bluuebunny/crossref_metadata_2025_split huggingface dataset:
KETENTUAN HUKUM PIDANA ISLAM TERHADAP PELAKU MURTAD DIKAITKAN HAK ASASI MANUSIA BERDASARKAN HUKUM POSITIF INDONESIA
Authors: Handoko Duwi , Hasanah Rustam Martha 
Published: November 2021

Konsep masuk agama Islam tidak ada pemaksaan tetapi keluar dari agama Islam terdapat hukuman bagi pelakunya pada hakikatnya adalah suatu penyampaian Rasulullah kepada umat manusia yang diperintahkan oleh Allah SWT Yang Maha Melihat akan hamba-hamba- Nya. Barangsiapa yang masuk Islam, sesungguhnya mereka telah mendapat petunjuk dan barangsiapa yang murtad, maka kelak Allah akan mendatangkan suatu kaum yang Allah mencintai mereka dan merekapun mencintai-Nya, yang bersikap lemah lembut terhadap orang yang mukmin, yang bersikap keras terhadap orang-orang kafir, yang berjihad di jalan Allah, dan yang tidak takut kepada celaan orang yang suka mencela. Pengaturan pidana terhadap murtad dalam hukum pidana Islam adalah harus dibunuh setelah melewati tenggang waktu penasehatan dan eksekusi dilaksanakan oleh pihak berwenang, yakni atas perintah hakim. Sedangkan dalam hukum pidana positif di Indonesia, yang belum menerapkan hukum pidana Islam, maka orang murtad tidak dibunuh. Ketentuan hukum pidana Islam terhadap pelaku murtad dikaitkan dengan hak asasi manusia berdasarkan hukum positif Indonesia tentunya sesuatu hal yang tidak mungkin dilakukan saat ini.
Implementasi Sanksi Pidana Dalam Perlindungan Terbatas Jenis Ikan Terubuk Di Provinsi Riau.
Authors: Hidayat Tengku Arif , Lestari Maria Maya , Diana Ledy 
Published: November 2021

implementasi sanksi pidana dalam perlindungan terbatas jenis ikan terubuk di provinsi riau. Metodologi menggunakan metode sosiologis. Proses pelaksanaan Keputusan Menteri Kelautan dan Perikanan di provinsi riau masih hanya berupa pemberian teguran baik secara lisan maupun tertulis disertai dengan dilakukannnya proses sosialisasi secara berkelanjutan dengan melakukan penempelan stiker kepada kapal-kapal nelayan dan pembagian brosur tentang pelarangan pnagkapan ikan terubuk pada tempat tertentu dan pada waktu tertentu. Diharapkan dari adanya proses pemberian teguran dan sosialisasi secara berkelanjutan dapat dicapainya tujuan dari Keputusan Menteri Kelautan dan Perikanan berupa perlindungan ikan terubuk.
A RARE CASE OF VALENTINO SYNDROME- CASE REPORT
Authors: Phadnis Rohit K , Sharma Suditi , Patnala Sai Lavanya , Hussain Faiz , Chigulapalli Neha 
Published: November 2021

Background: Valentino’s syndrome refers to acute abdomen with clinical presentation mimicking acute appendicitis in a Perforated gastric or duodenal ulcer. This occurs when suppurative fluid from duodenal perforation trickles down the paracolic gutter to the right iliac fossa causing peritonitis locally and causes periappendicitis. Less than 50 cases have been reported in literature of the same.
Case report and discussion: A 42-year-old male was admitted to the general surgery department with pain in the right iliac fossa and epigastric region. A diagnostic laparoscopy was performed under the suspicion of Acute appendicitis, which was later converted to open laparotomy on finding a perforated duodenal ulcer.
Review of Literature: Valentino syndrome is a rare condition in which a duodenal ulcer mimics acute appendicitis which is a diagnosed intraoperatively and managed surgically.
Although the exact incidence is unknown, less than 50 cases have been reported worldwide. The first incidence reports back to 1926 when an Italian actor, Rodolfo Valentino who succumbed to this rare disease and it was named after him.
Conclusion: Differential diagnosis of duodenal ulcer perforation should be considered for adult patient with diagnosis of acute appendicitis. X ray erect abdomen and diagnostic laparoscopy can help to overcome foot in mouth situation due to missed duodenal ulcer perforation.
Keywords: Valentino syndrome.
THE EPIDEMIOLOGICAL PROFILE OF COVID-19 PATIENTS
Authors: Gahlot Sangeeta , Yadav Surendra , Saini Makkhan Lal 
Published: November 2021

Background: In this study, epidemiological profiles of COVID-19 patients who have visited the hospital have been evaluated.
Methods: We collected data of 100 patients from their medical records. These data included age, sex, comorbidities, levels of illness severity (mild, moderate, severe, and asymptomatic), signs and symptoms, treatment options, laboratory findings, and computed tomography (CT) images
Results: The mean age were 61.23±12.36 years with age groups ranging from 17 to 85 years. Men were 69; M:F ratio being 2.26:1. There were 76 symptomatic and 24 asymptomatic patients. Mortality was higher in symptomatic patients.
Conclusion: Patients aged more than 60 years are more prone for severe disease with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pneumonia and this subset of patients requires urgent medical attention.
Keywords: Age, Sex, COVID-19.
Determinación de metales pesados en material particulado atmosférico por espectroscopía de absorción atómica: validación
Authors: Sarmiento-Gamero Maria Fernanda , Ramos-Contreras Carlos Daniel , Flórez-Pérez Sofía Lorena , Molina-Pérez Francisco José 
Published: November 2021

El análisis de Cr, Cd, Pb y Ni en material particulado (PM10) permite establecer los niveles de exposición y de cuantificación, empleando digestión ácida asistida por microondas y espectroscopía de absorción atómica. Se evaluaron los parámetros: linealidad, límite de detección y de cuantificación, precisión y veracidad. Se obtuvo comportamiento lineal (R2>0,995) entre 0,75-2,5 μgCd, 8,75-125 μgNi, 5-25 μgCr y 8,75-15 μgPb. También, se evidenció efecto matriz (α=0.05) en todos los metales estudiados. Los coeficientes de variación (0,9-12%) y los porcentajes de recuperación (66-126%) se encontraron dentro de los intervalos permitidos. El análisis del material de referencia (NIST 1649b Urban Dust) permitió determinar la veracidad de la metodología (71-102 % R). Por consiguiente, la metodología puede ser implementada para evaluar de manera confiable, el cumplimiento de la resolución 2254:2017 del Ministerio de Medio Ambiente y Desarrollo Sostenible.
The analysis of Cr, Cd, Pb, and Ni in particulate matter (PM10) makes it possible to establish the levels of exposure and risk to the health of the population. This work presents the validation and implementation of analytical methodologies, using microwave-assisted acid digestion and atomic absorption spectroscopy. The parameters were evaluated: linearity, the limit of detection and quantification, precision, and veracity. Linear behavior (R2> 0.995) was obtained between 0.75-2.5 μg Cd, 8.75-125 μg Ni, 5-25 μg Cr and 8.75-15 μg Pb. Also, a matrix effect (α = 0.05) was evidenced in all the metals studied. The coefficients of variation (0.9-12%) and the recovery percentages (66-126%) were found within the allowed intervals. The analysis of the reference material (NIST 1649b Urban Dust) allowed to establish the veracity of the methodology (71-102 % R). Finally, the methodology can be implemented to reliably assess compliance with resolution 2254: 2017 of the Ministry of the Environment and Sustainable Development.
Descripción del movimiento humano basado en el marco de Frenet Serret y datos tipo MOCAP
Authors: Hernandez-Gomez Juan Camilo , Restrepo-Martínez Alejandro , Valencia-Aguirre Juliana 
Published: November 2021

Clasificar el movimiento humano se ha convertido en una necesidad tecnológica, en donde para definir la posición de un sujeto requiere identificar el recorrido de las extremidades y el tronco del cuerpo, y tener la capacidad de diferenciar esta posición respecto a otros sujetos o movimientos, generándose la necesidad tener datos y algoritmos que faciliten su clasificación. Es así, como en este trabajo, se evalúa la capacidad discriminante de datos de captura de movimiento en rehabilitación física, donde la posición de los sujetos es adquirida con el Kinect de Microsoft y marcadores ópticos, y atributos del movimiento generados con el marco de Frenet Serret, evaluando su capacidad discriminante con los algoritmos máquinas de soporte vectorial, redes neuronales y k vecinos más cercanos. Los resultados presentan porcentajes de acierto del 93.5% en la clasificación con datos obtenidos del Kinect, y un éxito del 100% para los movimientos con marcadores ópticos.
Classify human movement has become a technological necessity, where defining the position of a subject requires identifying the trajectory of the limbs and trunk of the body, having the ability to differentiate this position from other subjects or movements, which generates the need to have data and algorithms that help their classification. Therefore, the discriminant capacity of motion capture data in physical rehabilitation is evaluated, where the position of the subjects is acquired with the Microsoft Kinect and optical markers. Attributes of the movement generated with the Frenet Serret framework. Evaluating their discriminant capacity by means of support vector machines, neural networks, and k nearest neighbors algorithms. The obtained results present an accuracy of 93.5% in the classification with data obtained from the Kinect, and success of 100% for movements where the position is defined with optical markers.
Uso de ladrillos triturados en concreto: una revisión literaria
Authors: Muñoz-Pérez Sócrates Pedro , Mimbela-Orderique Felipe , Rodriguez-Lafitte Ernesto Dante 
Published: November 2021

El ladrillos es uno de los materiales mas requeridos para la construcción de viviendas, los cuales debido a un exceso de compra, o por rotura mediante traslado no se utilizan totalmente. El presente trabajo tiene como objetivo lograr una revisión sistematica sobre el uso de ladrillos triturados en el concreto, con el fin de sintetizar los resultados obtenidos y discutir la posibilidad de poder utilizar en las diferentes áreas de la construcción este material reciclado. Se hizo una revisión de 50 articulos indexados entre los años 2015 al 2021, distribuido de la siguiente manera: 40 articulos son de Scopus y 10 de Sciencedirect, de los cuales muestran como influye el ladrillo triturado en las propiedades del concreto. La revisión de los resultados constataron que los agregados de ladrillos reciclados (RBA) generan una deficiencia en resistencia a la compresión y una mayor porosidad a diferencia del agregado natural (NA).
Определение вертикального градиента силы тяжести на территорию Западной Сибири
Authors: Канушин Вадим Федорович , Ганагина Ирина Геннадьевна , Голдобин Денис Николаевич 
Published: November 2021

Вертикальный градиент силы тяжести имеет большое практическое значение, его использование позволяет значительно расширить возможности по локализации и интерпретации гравитационных аномалий. Благодаря применению измеренного вертикального градиента силы тяжести на земной поверхности возможно повысить точность приведения к отсчетной поверхности измеренных значений ускорения силы тяжести, а также найти среднюю кривизну уровенной поверхности.
Для региональных исследований гравитационного поля предложено использовать определение вертикальной составляющей градиента силы тяжести с помощью разложения в ряд Фурье по системе сферических функций.
Приведены результаты вычисления вертикального градиента силы тяжести на территории Западной Сибири по гармоническим коэффициентам современной глобальной модели геопотенциала EIGEN-6C4. Приведены результаты сравнения вертикальных градиентов поля силы тяжести, вычисленными по гармоническим коэффициентам современных глобальных моделей геопотенциала, и с вертикальными градиентами, полученными из измерений высокоточными гравиметрами. Установлено, что отличия нормального значения от вычисленных вертикальных градиентов достигают 662,4 Э.
Правовые и технологические особенности реализации «дачной амнистии»
Authors: Шарапова Татьяна Николаевна , Митрофанова Наталья Олеговна , Норкин Владимир Игоревич 
Published: November 2021

Актуальность данной темы обусловлена активной реализацией граждан возможности упрощенного порядка кадастрового учета и регистрации прав на отдельные виды объектов недвижимости. Данный порядок имеет свои отличительные особенности от стандартной процедуры и оснований для кадастрового учета и регистрации прав.
В данной работе описывается процедура упрощенного порядка государственного кадастрового учета и государственной регистрации прав граждан на объекты недвижимости в рамках «дачной амнистии», существующие проблемы и результаты реализации «дачной амнистии».
A Fast, Visual, and Instrument-free Platform Involving Rapid DNA Extraction, Chemical Heating, and Recombinase Aided Amplification for On-Site Nucleic Acid Detection
Authors: Wang Xiao Fu , Chen Wen Qiang , Guo Jian Li , Peng Cheng , Chen Xiao Yun , Xu Xiao Li , Wei Wei , Yang Lei , Ca Jian , Xu Jun Feng 
Published: November 2021

The nucleic acid-based technique has been widely utilized in many fields including for on-site detection. However, traditional molecular detection techniques encounter limitations like relying on instruments, time consuming or complex operation, and cannot meet the demands of on-site testing. In this study, a rapid DNA extraction method (RDEM), recombinase aided amplification (RAA), and chemical heating packet (CHP) are integrated and termed as RRC platform for on-site detection of nucleic acid. For demonstration purposes, SHZD32-1 (a new transgenic soybean line from China) was detected using the novel platform to demonstrate its feasibility and capability for on-site detection. Using the RDEM, high-quality DNA appropriate for molecular detection was quickly extracted in 3–5 min. The heat energy generated by CHP was met the temperature requirements of RAA. Using the RRC platform, the whole detection process can be accomplished within only 30 min, and the results can be visually detected with glasses under blue light. No special or expensive instrument was needed for the detection process. This study provides a novel approach for on-site detection of nucleic acids besides providing valuable insight on related future research.
Microbial Flora Changes in Cesarean Section Uterus and Its Possible Correlation With Inflammation
Authors: Yang Xing , Pan Xinyi , Cai Meihong , Zhang Bolun , Liang Xiaoyan , Liu Guihua 
Published: November 2021

Background: It has not been fully elucidated whether the change of the uterus flora is correlated to impaired fecundity. This case-control study aimed to analyze the differences in uterus microbial flora between women with post-cesarean section (CS) scar diverticulum (PCSD) (CS group) and women after vaginal delivery (control group), exploring the correlation between differentially expressed microbial flora and inflammation.Methods: Infertile women who underwent hysteroscopy were enrolled in this case-control study. The swab samples were classified into four subgroups: CS cervix group, CS endometrium group, control cervix group, and control endometrium group. The total DNA obtained from 16 women (a total of 31 samples, the cervix or endometrium) was extracted for 16S recombinant DNA (rDNA) analysis. The Luminex platform was used to detect the abundance of 34 kinds of local inflammatory cytokines in 32 endometrium samples, and the correlation between microbial flora and inflammatory cytokines was analyzed.Results: The alpha and beta diversity analysis indicated that the microbial diversity was higher in the CS group compared to the control group, especially in endometrium tissues. The heatmaps revealed that the microbial flora structure differs at each level of the phylum-class-order-family-genus among the groups. The analysis of four of the most prominently changed microbial flora revealed that Lactobacillus in the cervix was significantly higher in the control group when compared with the cesarean section group (P &lt; 0.05). Furthermore, Proteobacteria and Neisseriaceae had a higher abundance in the CS groups, especially in the cervical tissue (P &lt; 0.05), while Staphylococcaceae increased only in the CS endometrium tissue (P &lt; 0.05). Next, these women were re-divided into the high- and low-Staphylococcaceae, and the abundance of 34 kinds of local inflammation cytokines was compared between groups. It was found that there was a positive correlation between Staphylococcaceae and IL-2, and a negative correlation between Staphylococcaceae and IL-8 (P &lt; 0.05).Conclusion: The present results suggest that the disrupted uterus microbiota composition in women with CS may be closely associated with local inflammation. The interplay between the microbiota and the immune system may be linked to clinical disorders. The potential mechanisms require further exploration.
Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
Authors: Ren Xiang-bin , Zhao Jing , Liang Xue-feng , Guo Xu-dong , Jiang Shao-bo , Xiang Yu-zhu 
Published: November 2021

Background: Tripartite motif containing 46 was initially identified as the oncogene in several human tumors. However, the clinical value and potential functions of tripartite motif containing 46 (TRIM46) in clear cell renal cell carcinoma (ccRCC) remained largely unclear.Methods: The expressing patterns, clinical involvement, and prognostic values of TRIM46 were analyzed using the data obtained from TCGA and GEO databases. A nomogram was constructed to examine the outcome of patients with ccRCC. We estimated the association between TRIM46 with tumor immunity in ccRCC.Results: Tripartite motif containing 46 was highly expressed in ccRCC, and its upregulation revealed an unfavorable prognosis. A nomogram based on TRIM46 expressions and other independent prognostic factors could robustly predict the overall survival of tumor patients. TRIM46 has a strong positive correlation with NUMBL, CACNB1, THBS3, ROBO3, MAP3K12, ANKRD13D, PIF1, PRELID3A, ANKRD13B, and PCNX2. Mechanically, TRIM46 displayed regulatory functions in ccRCC progression via several tumor-associated pathways. Besides, we observed that TRIM46 was distinctly related to tumor immunity in ccRCC.Conclusions: Our findings provide a novel tumor promotive role regarding TRIM46 function in the malignant progression of ccRCC.
Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
Authors: Khunkhet Saranya , Chanprapaph Kumutnart , Rutnin Suthinee , Suchonwanit Poonkiat 
Published: November 2021

Background: The occipital region of the scalp is generally accepted as an unaffected area of androgenetic alopecia (AGA) for both genders. However, evidence of AGA involving the occipital scalp has been demonstrated in women; meanwhile, it is unclear whether occipital involvement also occurs in men.Objective: We aimed to determine if there is occipital involvement in men with AGA.Methods: This case-control study compared hair counts of scalp biopsy specimens from the occipital region of 82 men with Hamilton-Norwood III-VII and 82 unaffected men.Results: The mean ages of men with AGA and controls were 40.1 ± 8.9 and 38.6 ± 10.5 years, respectively (P = 0.291). A significant decrease in total hair follicles, terminal hair follicles, follicular units and terminal to vellus (T:V) ratio, along with a significant increase in follicular stelae was indicated in the AGA group compared to controls (all P &lt; 0.05). Subgroup analyses revealed that average counts of total hair follicles, terminal hair follicles and T:V ratios were also significantly lower in males with Hamilton-Norwood VI and VII than in controls (all P &lt; 0.05). There were no correlations between increasing age and hair count parameters, but a significant negative association was found between total follicle numbers and disease duration (r = −0.23, P = 0.02).Conclusions: AGA can involve the occipital area of male patients with advanced disease. Therefore, the occiput of particular cases should not be used to determine reference data for normal scalp hair, and preoperative measurements of miniaturized hairs in the donor site are strongly recommended in all persons undergoing hair transplantation.
Reasons and Factors Contributing to Chinese Patients’ Preference for Ustekinumab in Crohn’s Disease: A Multicenter Cross-Sectional Study
Authors: Yao Lingya , Zhu Xiao , Shao Bule , Liu Rongbei , Li Zhilun , Wu Lexi , Chen Jin , Cao Qian 
Published: November 2021

Background and Aims: Ustekinumab (UST) was approved in China for treating moderate-to-severe Crohn’s disease (CD) in 2020. We aimed to identify the reasons and possible contributing factors for UST preference in Chinese patients with CD.Methods: We conducted a multicenter cross-sectional survey among patients with moderate to severe CD who underwent UST treatment in 27 hospitals. Patients completed a 46-item questionnaire that included information on demographics, clinical characteristics, reasons in favor of UST and shared decision-making perception. Logistic regression analysis was performed to examine the predictive factors of different UST preferences.Results: Overall, 127 patients (73 males; mean age, 25.9 ± 9.9 years) completed the questionnaire. Most patients (74.8%) had biologic failure. The most common reason for the latest treatment disconnection was unresponsiveness to the previous medications. The major UST information sources were physicians (96.1%). Nearly half of the patients (44.9%) reported shared decision making regarding UST treatment. No difference was found in the decision-making patterns in terms of sex and age. The most influential reason for UST preference was “effectiveness” (77%, 98/127), followed by “safety” (65%, 83/127), “frequency of administration” (39%, 49/127), and “mode of administration” (37%, 47/127). Multivariate logistic regression analysis revealed that a positive self-rated health status was a contributing factor for UST preference with a low frequency of administration.Conclusion: This is the first multicenter survey of Chinese patients with CD to identify the possible contributing factors for UST preference. Treatment choice should be discussed with patients because individual preferences are determined by diverse factors.
Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib
Authors: Liu Hongrui , Yu Yiqun , Guo Nan , Wang Xiaojuan , Han Bing , Xiang Xiaoqiang 
Published: November 2021

Aim: Apatinib is an orally administered vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitors approved for the treatment of advanced gastric adenocarcinoma or gastric esophageal junction adenocarcinoma. Apatinib is predominantly metabolized by CYP3A4/5, followed by CYP2D6. The present study aimed to evaluate the potential drug–drug interaction (DDI) and drug–disease interaction (DDZI) risks of apatinib in Chinese volunteers.Methods: Modeling and simulation were conducted using Simcyp Simulator. The input parameters required for modeling were obtained from literature research or experiments. Then, the developed physiologically based pharmacokinetic (PBPK) models were applied to evaluate single-dose DDI potential in Chinese healthy volunteers with weak and moderate CYP3A inhibitors, strong CYP2D6 inhibitors, as well as CYP3A4 inducers. The DDZI potential was also predicted in patients with hepatic or renal impairment.Results: The developed PBPK models accurately assessed apatinib pharmacokinetics following single-dose administration in Chinese healthy volunteers and cancer patients. The DDI simulation showed 2–4-fold changes in apatinib exposures by moderate CYP3A4 inhibitors and CYP3A4 inducers. A moderate increase of apatinib exposure (1.25–2-fold) was found with strong CYP2D6 inhibitor. In the DDZI simulation with hepatic impairment, the AUC of apatinib was significantly increased by 2.25-fold and 3.04-fold for Child–Pugh B and Child–Pugh C, respectively, with slightly decreased Cmax by 1.54 and 1.67-fold, respectively.Conclusion: The PBPK models developed in the present study would be highly beneficial to quantitatively predict the pharmacokinetic changes of apatinib under different circumstances, which might be difficult to evaluate clinically, so as to avoid some risks in advance.