bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seizures and Interictal Epileptiform Activity in the Rat Collagenase Model for Intracerebral Hemorrhage
Authors: Germonpré Charlotte , Proesmans Silke , Bouckaert Charlotte , Sprengers Mathieu , Boon Paul , Raedt Robrecht , De Herdt Veerle 
Published: June 2021

AimsIntracerebral hemorrhage (ICH) is a known risk factor for the development of acute symptomatic as well as late unprovoked seizures. The underlying pathophysiology of post-ICH seizures is incompletely understood and there are no reliable predictive biomarkers. An animal model to study post-ICH seizures is currently lacking. The aim of this study was to investigate (1) the occurrence of seizures and interictal epileptiform activity in the ICH rat collagenase model using long-term video-EEG monitoring (VEM) and (2) whether seizure occurrence was associated with interictal epileptiform activity and histological features.MethodsMale Sprague-Dawley rats were implanted with epidural electrodes. After 1 week of baseline VEM, collagenase was injected in left striatum to induce an ICH. VEM was continued for 180 days to assess the occurrence of post-ICH seizures and interictal epileptiform activity (spikes and epileptiform discharges). At the end of the experiment, animals were euthanized for histological characterization of the hemorrhagic lesion, using cresyl violet, Prussian blue and immunofluorescence staining.ResultsAcute symptomatic seizures occurred in 4/12 animals between 46 and 80 h after ICH induction. Late unprovoked seizures were present in 2/12 animals and started at 90 and 103 days post-ICH. Animals with late unprovoked seizures did not have acute symptomatic seizures. All electrographic seizures were accompanied by clear behavioral changes. Interictal spikes and epileptiform discharges were observed in all animals but occurred more frequently in rats with late seizures (p = 0.019 and p &lt; 0.001, respectively). Animals with acute symptomatic seizures had more extended hemorrhagic lesions and hemosiderin deposits in the piriform cortex.ConclusionBoth acute symptomatic and late unprovoked seizures were observed in the rat collagenase model. Interictal epileptiform activity was more frequently seen in animals with late seizures. Rats with acute symptomatic seizures showed more extensive lesions and hemosiderin deposits in the piriform cortex. This model could be used to further explore possible biomarkers for epileptogenesis.
Radiofrequency Catheter Ablation of Supraventricular Tachycardia in Patients With Pulmonary Hypertension: Feasibility and Long-Term Outcome
Authors: Zhou Bin , Zhu Yong-Jian , Zhai Zheng-Qin , Weng Si-Xian , Ma Ya-Zhe , Yu Feng-Yuan , Qi Ying-Jie , Jiang Yi-Zhou , Gao Xin , Xu Xi-Qi , Jiang Xin , Jing Zhi-Cheng , Tang Min 
Published: June 2021

BackgroundSupraventricular tachycardia (SVT) occurs commonly and is strongly correlated with clinical deterioration in patients with pulmonary hypertension (PH). This study aimed to investigate the feasibility and long-term outcome of radiofrequency catheter ablation (RFCA) in PH patients with SVT.Materials and MethodsConsecutive PH patients with SVT who were scheduled to undergo electrophysiological study and RFCA between September 2010 and July 2019 were included. The acute results and long-term success of RFCA were assessed after the procedure.ResultsIn total, 71 PH patients with 76 episodes of SVT were analyzed. Cavotricuspid isthmus-dependent atrial flutter (n = 33, 43.5%) was the most common SVT type, followed by atrioventricular nodal reentrant tachycardia (n = 16, 21.1%). Of the 71 patients, 60 (84.5%) underwent successful electrophysiological study and were subsequently treated by RFCA. Among them, acute sinus rhythm was restored in 54 (90.0%) patients, and procedure-related complications were observed in 4 (6.7%) patients. Univariate logistic regression analysis showed that cavotricuspid isthmus-independent atrial flutter [odds ratio (OR) 25.00, 95% confidence interval (CI) 3.45–180.98, p = 0.001] and wider pulmonary artery diameter (OR 1.19, 95% CI 1.03–1.38; p = 0.016) were associated with RFCA failure. During a median follow-up of 36 (range, 3–108) months, 7 patients with atrial flutter experienced recurrence, yielding a 78.3% 3-year success rate for RFCA treatment.ConclusionThe findings suggest that RFCA of SVT in PH patients is feasible and has a good long-term success rate. Cavotricuspid isthmus-independent atrial flutter and a wider PAD could increase the risk for ablation failure.
Adjustment of Couples to the Transition to Retirement: The Interplay of Intra- and Interpersonal Emotion Regulation in Daily Life
Authors: Horn Andrea B. , Holzgang Sarah A. , Rosenberger Vanessa 
Published: June 2021

Background: Retirement is a central transition in late adulthood and requires adjustment. These processes not only affect the retired individuals but also their romantic partners. The aim of this study is to investigate the interplay of intrapersonal emotion regulation (rumination) with interpersonal regulation processes (disclosure quality). Furthermore, the associations of daily retirement-related disclosure with adjustment symptoms in disclosing and the listening partner will be investigated. It is expected that the effects of disclosure alter after providing the couples with a self-applied solitary written disclosure task in order to support their intrapersonal emotion regulation.Methods: In this dyadic online-diary study, 45 couples (N = 45) with one partner perceiving the adjustment to a recent retirement as challenging reported rumination, perceived disclosure quality (repetitive, focused on negative content, hard to follow, disclosing partner open for common/authentic), retirement-related disclosure, and ICD-11 adjustment symptoms preoccupation and failure to adapt were assessed at the end of the day over 14 days. In the middle of this assessment period, couples performed a modified online-expressive writing about their thoughts and feelings regarding the transition to retirement.Results: The double-intercept multilevel Actor–Partner Interdependence Models (APIM) reveal that on days with more daily rumination, the spouse perceived that disclosure of the retiree is more difficult to follow, more negative, and repetitive. In contrast, the retiree perceived less authenticity and openness to comments during disclosure on days when the spouse reports more rumination. Retirement-related disclosure showed no within-couple association with failure to adapt but actor effects on preoccupation. Moreover, a partner effect of disclosure of the retirees on the preoccupation of spouses could be observed. This contagious effect of the retiree disclosure, however, disappeared during the week after writing.Conclusion: Our results support the notion that disclosure processes are altered during maladaptive intrapersonal emotion regulation processes. This in turn seems to lead to less effective interpersonal regulation and contagious spilling over of symptoms.Supporting intrapersonal emotion regulation seems to have the potential to allow more favorable interpersonal regulation processes and to free interpersonal resources for an individual adjustment. This has implications for further planning of support for couples facing life transitions and aging-related changes.
A Focus Group Study Among Inactive Adults Regarding the Perceptions of a Theory-Based Physical Activity App
Authors: Nibbeling Nicky , Simons Monique , Sporrel Karlijn , Deutekom Marije 
Published: June 2021

Background: Despite the increasing attention for the positive effects of physical activity (PA), nearly half of the Dutch citizens do not meet the national PA guidelines. A promising method for increasing PA are mobile exercise applications (apps), especially if they are embedded with theoretically supported persuasive strategies (e.g., goal setting and feedback) that align with the needs and wishes of the user. In addition, it is argued that the operationalization of the persuasive strategies could increase the effectiveness of the app, such as the actual content or visualization of feedback. Although much research has been done to examine the preferences for persuasive strategies, little is known about the needs, wishes, and preferences for the design and operationalization of persuasive strategies.Objective: The purpose of this study was to get insight in the needs, wishes, and preferences regarding the practical operationalization of persuasive strategies in a mobile application aimed at promoting PA in healthy inactive adults.Methods: Five semistructured focus groups were performed. During the focus groups, the participants were led into a discussion about the design and operationalization of six predefined theory-based persuasive strategies (e.g., self-monitoring, feedback, goal setting, reminders, rewards, and social support) directed by two moderators. The audio-recorded focus groups were transcribed verbatim and analyzed following the framework approach.Results: Eight men and 17 women between 35 and 55 years (mean age, 49.2) participated in the study. Outcomes demonstrated diverse preferences for implementation types and design characteristics of persuasive strategies in mobile applications. Basic statistics (such as distance, time and calories), positive feedback based on easy-to-achieve goals that relate to health guidelines, and motivating reminders on a relevant moment were preferred. Participants had mixed preferences regarding rewards and a social platform to invite other users to join PA.Conclusions: Findings indicated that in mHealth applications for healthy but inactive adults, persuasive strategies should be designed and implemented in a way that they relate to health guidelines. Moreover, there is a need for an app that can be adapted or can learn based on personal preferences as, for example, preferences with regard to timing of feedback and reminders differed between people.
MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung Carcinoma
Authors: Qin Jing , Xie Fajun , Li Chenghui , Han Na , Lu Hongyang 
Published: June 2021

Purpose: The Myc family, especially C-MYC and MYCL1, has been found involved in small-cell lung carcinoma (SCLC). Identification of the frequency of C-MYC and MYCL1 expression among SCLC patients may help to identify potential targets for therapeutic intervention. Our aim was to detect MYCL1 amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC.Methods:MYCL1 amplification was detected using fluorescence in situ hybridization (FISH), while L-Myc and c-Myc protein expressions were determined using immunohistochemistry (IHC) in the primary tumors of 46 resected SCLC patients.Results: Among the 46 evaluated specimens, MYCL1 amplification was identified in 3/46 cases (6.5%). One of the positive cases was MYCL1 gene amplification combined with fusion. 3/46 (6.5%) was positive for L-myc protein expression, and 4/46 (8.7%) was positive for c-Myc protein expression.Conclusion: Our study firstly multidimensional explored the expression of MYCL1 amplification, L-Myc and c-Myc protein and investigated clinicopathological characteristics and survival status in patients with surgically resected SCLC, which makes a contribution to subsequent research and therapeutic strategies.
Business Strategy, ISO 31000 and Bankruptcy Risk
Authors: Jannah Lu'lu'ul , Purnomosidi Ridho Muhammad 
Published: June 2021

The purpose of this study is to examine the effect of business strategy to bankruptcy risk and the effect moderate of ISO 31000 to business strategy and bankruptcy. The sample of this study is 50 firms listed on the Indonesia Stock Exchange (IDX). the results support that business strategy has a significant effect on bankruptcy risk. Firms which implement either one of two generic business strategies of cost leadership or differentiation, sig-nificantly effect to the risk of bankruptcy. the second result is ISO 31000 has not effect moderated to business strategy and bankruptcy risk
The Influence of Work Motivation, Organizational Commitment and Organizational Culture on Employee Performance of Sharia Bank
Authors: WIDYANINGSIH DEWI - , WIDYANINGSIH DEWI - , WIDYANINGSIH DEWI - 
Published: June 2021

The goal of this research is to investigate the effects of job motivation, organizational commitment, and organizational culture on the performance of Islamic bank employees. The scope of this research is limited to a single Islamic bank branch in Central Java. This is a quantitative study in which the data was collected using a questionnaire. The participants in this study were chosen from a population of 30 people using saturated sampling or census sampling methods, in which samples were taken from the entire community. SPSS 23 for Windows was used to analyze the data, which was done using multiple linear regression. All independent variables have a positive and significant influence on sharia bank workers' performance factors, either partially or simultaneously, according to the study.
PENGARUH KEBIJAKAN KESELAMATAN DAN KESEHATAN KERJA (K3) TERHADAP KINERJA KARYAWAN
Authors: Sugiyanto Sugiyanto , Sulfiani Sulfiani 
Published: June 2021

Kebijakan keselamatan dan kesehatan kerja berbeda antara suatu perusahaan tertentu dibandingkan perusahaan lainnya, tergantung tingkat kepedulian manajemen puncak terhadap perlindungan pekerja dari bahaya di tempat kerja. Tujuan penelitian ini untuk mengetahui pengaruh kebijakan keselamatan dan kesehatan kerja terhadap kinerja karyawan pada perusahaan yang diteliti. Pengukuran variabel menggunakan skala Likert dengan skala angka 1 sampai 5, untuk mengukur sikap, pendapat dan persepsi pekerja tentang pelaksanaan program K3 di tempat mereka bekerja. Teknik pengumpulan data dengan metode kuisioner memuat sejumlah pertanyaan dibagikan kepada pekerja (responden). Hasil penilaian responden diolah menggunakan metode partial least square. Berdasarkan atas evaluasi outer model menunjukkan indikator yang digunakan untuk mengukur variabel laten (variabel bebas dan variabel terikat) telah memenuhi uji validitas dan realibilitas. Berdasarkan atas evaluasi inner model dapat dibuktikan adanya korelasi nyata terhadap kinerja karyawan, yaitu lingkungan kerja 55%, kompetensi pekerja 52%, komitmen top management 47% dan komunikasi pekerja 39%. Adapun untuk peraturan dan prosedur K3 serta keterlibatan pekerja didapatkan cukup kecil masing-masing 10% dan 9% pengaruhnya terhadap kinerja karyawan dan besarnya pengaruh tersebut menunjukkan tidak nyata.
PENERAPAN LOGAM ANTIMIKROBA (KAWAT TEMBAGA) UNTUK MENURUNKAN KADAR E-COLI, TOTAL COLIFORM DAN TEMBAGA PADA AIR SUNGAI
Authors: Pungut Pungut , Sutrisno Joko , Nuryanto Didik 
Published: June 2021

Beberapa tahun terakhir kualitas sungai di Indonesia mengalami penurunan, terutama setelah melalui daerah permukiman, industri dan pertanian. Bakteri Escherichia Coli (E.coli) adalah bakteri yang paling banyak mengkontaminasi air. Logam merupakan alternatif desinfeksi yang potensial untuk digunakan. Tembaga adalah antimikroba yang memiliki kemampuan melawan bakteri. Tujuan dari penelitian ini adalah untuk mengetahui removal kadar E.coli, Total coliform dan kadar Tembaga dengan menggunakan kawat tembaga. Air hasil filtrasi direndam di 3 reaktor yang terbuat dari fiber plastik berisi kawat tembaga variasi panjang kawat tembaga 6 meter, 9 meter dan 12 meter dan diambil sampel untuk diuji laboratorium setiap 2,5 jam sebanyak 3 kali. Efisiensi removal yang optimum kadar E.coli , Total Coliform dan kadar Tembaga dengan variasi kawat tembaga 6 meter, 9 meter dan 12 meter dan variasi waktu 2,5 jam, 5 jam dan 7,5 jam adalah kadar e.coli 60% turun setelah 7,5 jam perendaman kawat tembaga panjang 6 meter. Sedangkan kadar total colifom mencapai optimal pada variasi kawat tembaga panjang 9 meter dengan waktu 5 jam sebanyak 70,92%. Dan kadar tembaga dalam air tidak ada penurunan maupun kenaikan kadar dari semua variasi (konstan). Kawat tembaga mampu menurunkan kadar E.coli dan total Coliform. Sedangkan perbedaan kawat tembaga tidak memiliki pengaruh terhadap kadar tembaga.
Los recursos tecnológicos en las habilidades investigativas
Authors: Choez Hungría Bella 
Published: June 2021

Se analiza el contexto de la participación de los estudiantes en la investigación y en eventos científicos donde se permitan realizar un estudio de campo donde la metodología y su didáctica se vea utilizada permita establecer métodos científicos como histórico- lógico y deductivo-inductivo entre otros sitios web o aulas virtuales que Se verán realizado mediantes encuestas y entrevistas a los docentes, autoridades y estudiantes de dicha instituciones con el fin de determinar los objetivos de nuestra investigación. El trabajo de investigación enfatiza en la importancia de motivar a los estudiantes y docentes en las habilidades investigativas, son un recurso tecnológico fundamental en su etapa de preparación ya al desarrollo de su formación profesional. Por ende, se elaboró un sitio web y aulas virtuales donde relatara la historia de la evolución y comportamiento del trabajo científico estudiantil de dichas institución y se incluirán las habilidades investigativas para el desarrollo del proceso de enseñanza-aprendizaje inherentes a la formación de un docente frente a los estudiantes, con el nombre de “FILOMEDIA”.
Fortalecimiento de la motricidad gruesa en espacios cerrados
Authors: Jiménez Valles Gloria Yaneth , Romero Castillo Claudia Patricia 
Published: June 2021

La educación a la primera infancia, es un ciclo vital en el desarrollo del ser humano, enmarcado jurídicamente y reconocido por primera vez de manera legal en el Código de la Infancia y Adolescencia (Artículo 29, Ley 1098 de 2006): "la primera infancia es la etapa del ciclo vital en la que se establecen las bases para el desarrollo cognitivo, emocional y social del ser humano”. Partiendo de lo anterior, se ha ampliado la cobertura para esta población sin medir el tipo de infraestructura que les garantice a los niños y niñas el bienestar y fortalecimiento de sus necesidades básicas. Donde se han venido adecuando casas de tipo doméstico, en zonas residenciales, con poco o nada de espacio de zona verde, lo que no le permite al niño vitalizar su motricidad gruesa con total plenitud. Este artículo reconoce los beneficios que tiene para la primera infancia, el fortalecimiento de la motricidad gruesa y hace un aporte para crear la necesidad a este tipo de instituciones educativas a aplicar actividades que contribuyan al fortalecimiento motriz, pese a no contar con espacios los adecuados para su desarrollo.
Competencia comunicativa: la argumentación en estudiantes del primer ciclo de la UCSG: un estudio de casos
Authors: Ayala Clara 
Published: June 2021

La argumentación es una destreza del pensamiento y del lenguaje que los estudiantes universitarios deben manejar con excelencia, pero los resultados nos demuestras que no es así. Es[cibb1] necesario que esta destreza deba ser desarrollada desde edad temprana y lo indicado sería hacerlo con ejemplos de la vida diaria. Para este estudio de caso se eligieron estudiantes del primer ciclo. Era necesario que los estudiantes hicieran investigaciones grupales para fortalecer el respeto y la tolerancia, rasgos necesarios para fortalecer la democracia. Para finalizar este estudio se aplicaría una rúbrica a las exposiciones individuales donde debían demostrar la destreza de su capacidad argumentativa. [cibb1]El trabajo no cumple con las caracterisiticas del curso el resumen no visualiza sus partes.
Aprendizaje en las redes sociales un enfoque de desarrollo en la comunidad
Authors: Galán Figueroa Patricia de los Ángeles , Hernández Gómez Ronald Mauricio , Espinoza Cordero Andrea Isabel 
Published: June 2021

Actualmente es evidente la importancia que ha tomado la inclusión de las Tecnologías de la Información y Comunicación (TIC) en los procesos de actualización de los programas Educativos. Las redes sociales son parte de los recursos de las TIC, pertenecientes a la web 2.0, y permiten una comunicación rápida y ágil de información entre sus usuarios, por lo que pueden ser un recurso idóneo para ser utilizadas con fines pedagógicos. Como propósito analizar el uso que docentes y estudiantes dan a las redes sociales como apoyo al proceso de aprendizaje, para qué actividades académicas sugieren su uso, cuál es la importancia que le dan como apoyo al aprendizaje, y la diferencia de opinión que existe entre Docentes y estudiantes sobre la importancia de su uso como una herramienta pedagógica. Con esa finalidad Se utilizó una encuesta tipo cuestionario, que fue aplicado a 133 estudiantes y 16 docentes de la Facultad de Ecología Humana de la Universidad Grande. Los resultados indican que los estudiantes en este caso que utilizan las redes sociales y sugieren su incorporación como apoyo a su procesode aprendizaje, mientras los docentes, aunque reconocen la importancia de incluirlas en sus Planificaciones, muestran aún recelos sobre su incorporación en la práctica pedagógica
Primeras medidas del tamaño del genoma en Carduncellusy los géneros afines Femeniasia y Phonus (Asteraceae, Cardueae), con datos para 21 táxones
Authors: Garnatje Teresa , Hidalgo Oriane , Vallés Joan , Garcia Sónia , Romo Àngel , Vilatersana Roser 
Published: June 2021

El tamaño del genoma de 18 especies del género Carduncellus, dos especies de los géneros relacionados, Phonus y el género monotípico Femeniasia (F. balearica) ha sido medido por primera vez mediante citometría de flujo. Los niveles de ploidía se asignaron utilizando datos de tamaño del genoma junto con los recuentos de cromosomas previamente reportados. Se construyó un marco filogenético para visualizar la distribución de las características citogenéticas de los táxones. Los resultados confirmaron tres niveles de ploidía (2x, 4x y 6x), con un predominio de los táxones diploides. Los valores de 2C oscilaron entre 3,24 pg en Carduncellus calvus y 11,16 pg en C. eriocephalus, mientras que el tamaño del genoma monoploide (1Cx) osciló entre 1,29 pg en C. duvauxii (4x) y 2,30 pg en Phonus rhiphaeus (2x). La media de los valores 1Cx para los tetraploides fue menor que para los diploides. Los valores de tamaño del genoma de Carduncellus, Femeniasia y Phonus fueron más elevados que los de Carthamus dentro del mismo nivel de ploidía. Este resultado concuerda con una tendencia frecuentemente observada en plantas en la que los táxones con ciclos de vida largos presentan tamaños del genoma más elevados que los táxones relacionados que poseen ciclos de vida cortos.