bluuebunny/crossref_metadata_2025_split huggingface dataset:
IDF (intensity-duration-frequency) curve and unit hydrograph as signature of characteristic changing of Way Kuala Garuntang Watershed
Authors: Jokowinarno D , Banuwa I S , Yuwono S B , Tugiyono  , Bakri S , Setiawan A 
Published: April 2021

Abstract
There is direct relation between global warming and precipitation. Air capacity of water increase by 7% to increasing of 1°C of air temperature, causing more water vapor content in the air. This research aims to investigate how IDF Curve and Unit Hydrograph can be used as signature of characteristic changing of Way Kuala Garuntang Watershed. The study area is Way Kuala Garuntang watershed and rainfall data source is from automatic rainfall recorder of Stasiun BMKG Maritim Panjang, ARR Tipping bucket installed at Way Kuala Garuntang watershed, and 4 manual raingauges. From the research can be concluded that IDF Curve can be used as signature of characteristic changing of Way Kuala Garuntang watershed mainly the changing of rainfall intensity in various of return period. Meanwhile, due to average of IUH of 5 flood events in 1 year data serie, and significant differences of Qp between IUH and SUH, the Unit Hydrograph was not suitable as signature of characteristic changing of Way Kuala Garuntang watershed.
Identification morphological variability of six mangosteen (Garcinia mangostana L.) As a conservation strategy for local varieties
Authors: Mulyono D , Irawati Y , Syah M J A 
Published: April 2021

Abstract
Morphological traits of six Mangosteen varieties were observed for two years from 2017 to 2019. This research aims to determine the growth and fruit characters of six mangosteen varieties in IP2TP Subang. The study was conducted in a randomized block design with 6 varieties: Kaligesing, Puspahiyang, Wanayasa, Ratu Kamang, Ratu Tembilahan, and Lingsar as a treatment and repeated 5 times. Each treatment unit is comprised of 6 trees. The observed characters comprised growth characters, leaf characters, and fruit characters. The results showed that the growth of several mangosteen varieties tested in relatively the same environmental conditions was quite varied, especially in the character of plant height and stem perimeter. Leaf character varied in leaf shape. Fruit characters also varied, especially characters fruit weight and plant with fruit. Ratu Tembilahan variety was the most adaptive variety because it had the highest growth ability and the highest fruit production.
Identification of changes in the morphological space structure of Bandar Lampung City using overlay geographic information system analysis
Authors: Ghazi A B , Fitra H A , Persada Citra 
Published: April 2021

Abstract
Cities are developing due to population growth, socio-economic structure changes, technology and spatial interaction with its surroundings. “Bagian Wilayah Kota (BWK) C” or so-called “urban zone C” of Bandar Lampung municipality comprising districts of Sukarame, Tanjung Senang, and Way Halim is currently growing both internally and externally due to the development of Trans-Sumatera highway and Institute Teknologi Sumatera (ITERA). The dynamics of development and activities have caused a growing physical urban space, affecting the changes of urban structure directly. The current development in BWK C has been considered as unmanageable and potentially caused some problems in spatial plan in the future. To prevent the chaotic of spatial plan in the future, this study aims to identify the changes of urban structure in BWK C of Bandar Lampung municipality due to the internal and external development of its area. This study benefits in providing comprehensive standpoints about the process of urban structure changes based on urban activities so that city government could gain a systematic discourse of urban development which advantages in policymaking for spatial development in Bandar Lampung municipality in the future. This study conducted several analytical methods ranging from comparative analysis, spatial analysis, and hierarchical centrality index analysis. For data collection, this study applied secondary data survey and field work observation, using data from 2010 to 2016. The findings of this study reveal that the physical development in BWK C is getting compacted as its morphology changed from ribbon shaped city to octopus shaped city.
Electrochemical reaction of corrosion and its negative economic impact
Authors: Akpoborie J. , Fayomi O.S.I. , Inegbenebor A.O. , Ayoola A.A. , Dunlami O. , Samuel O.D. , Agboola O. 
Published: April 2021

AbstractPersistent corrosion problems through hazardous chemicals and hydrocarbon are potentially harmful resulting into failure and breakdown of infrastructure in marine, oil and gas vessels, petroleum distillation plant, and chemical processing industries. Despite this unstoppable catastrophe, reduction in the amount of cost incurred by corrosion has been an effort by researcher in the field of material science to tackle. This paper addresses the major challenge of materials failure in services resulting to high cost, and the potential remedy form from several applications.
Omics community detection using multi-resolution clustering
Authors: Rahnavard Ali , Chatterjee Suvo , Sayoldin Bahar , Crandall Keith A , Tekola-Ayele Fasil , Mallick Himel 
Published: April 2021

AbstractMotivationThe discovery of biologically interpretable and clinically actionable communities in heterogeneous omics data is a necessary first step toward deriving mechanistic insights into complex biological phenomena. Here, we present a novel clustering approach, omeClust, for community detection in omics profiles by simultaneously incorporating similarities among measurements and the overall complex structure of the data.ResultsWe show that omeClust outperforms published methods in inferring the true community structure as measured by both sensitivity and misclassification rate on simulated datasets. We further validated omeClust in diverse, multiple omics datasets, revealing new communities and functionally related groups in microbial strains, cell line gene expression patterns and fetal genomic variation. We also derived enrichment scores attributable to putatively meaningful biological factors in these datasets that can serve as hypothesis generators facilitating new sets of testable hypotheses.Availability and implementationomeClust is open-source software, and the implementation is available online at http://github.com/omicsEye/omeClust.Supplementary informationSupplementary data are available at Bioinformatics online.
APOE ε4 alters associations between docosahexaenoic acid and preclinical markers of Alzheimer’s disease
Authors: Coughlan Gillian , Larsen Ryan , Kim Min , White David , Gillings Rachel , Irvine Michael , Scholey Andrew , Cohen Neal , Legido-Quigley Cristina , Hornberger Michael , Minihane Anne-Marie 
Published: April 2021

Abstract
Docosahexaenoic acid is the main long-chain omega-3 polyunsaturated fatty acids in the brain and accounts for 30−40% of fatty acids in the grey matter of the human cortex. Although the influence of docosahexaenoic acid on memory function is widely researched, its association with brain volumes is under investigated and its association with spatial navigation is virtually unknown. This is despite the fact that spatial navigation deficits are a new cognitive fingerprint for symptomatic and asymptomatic Alzheimer’s disease. We investigated the cross-sectional relationship between docosahexaenoic acid levels and the major structural and cognitive markers of preclinical Alzheimer’s disease, namely hippocampal volume, entorhinal volume and spatial navigation ability. Fifty-three cognitively normal adults underwent volumetric magnetic resonance imaging, measurements of serum docosahexaenoic acid (DHA, including lysophosphatidylcholine DHA) and APOE ε4 genotyping. Relative regional brain volumes were calculated and linear regression models were fitted to examine DHA associations with brain volume. APOE genotype modulated serum DHA associations with entorhinal cortex volume and hippocampal volume. Linear models showed that greater serum DHA was associated with increased entorhinal cortex volume, but not hippocampal volume, in non APOΕ ε4 carriers. APOE also interacted with serum lysophosphatidylcholine DHA to predict hippocampal volume. After testing interactions between DHA and APOE on brain volume, we investigated whether DHA and APOE interact to predict spatial navigation performance on a novel virtual reality diagnostic test for Alzheimer’s disease in an independent population of APOE genotyped adults (n = 46). APOE genotype modulated DHA associations with spatial navigation performance, showing that DHA was inversely associated with path integration in APOE ε4 carriers only. This exploratory analysis suggests that interventions aiming to increase DHA blood levels to protect against cognitive decline should consider APOE ε4 carrier status. Future work should focus on replicating our initial findings and establishing whether a specific dose of supplementary DHA, at a particular time in the preclinical disease course can have a positive impact on Alzheimer’s disease progression in APOE ε4 carriers.
Isavuconazole Treatment of Invasive Fungal Sinusitis: A Post Hoc Analysis of the SECURE and VITAL Trials
Authors: Durand Marlene L , Kitt Therese M , Song Yi , Marty Francisco M 
Published: April 2021

Abstract
This post hoc analysis of international phase III isavuconazole trials identified 50 patients (90% immunocompromised or diabetic) with invasive fungal sinusitis (88% mucormycetes, Aspergillus) who received isavuconazole as primary (n = 33) or salvage (n = 17) therapy for a median of 82 days (range, 2–882). Overall survival was 82% at day 42 and 70% at day 84.
Optimal Text Document Clustering Enabled by Weighed Similarity Oriented Jaya With Grey Wolf Optimization Algorithm
Authors: Venkanna Gugulothu , Bharati Dr K F 
Published: April 2021

Abstract
Owing to scientific development, a variety of challenges present in the field of information retrieval. These challenges are because of the increased usage of large volumes of data. These huge amounts of data are presented from large-scale distributed networks. Centralization of these data to carry out analysis is tricky. There exists a requirement for novel text document clustering algorithms, which overcomes challenges in clustering. The two most important challenges in clustering are clustering accuracy and quality. For this reason, this paper intends to present an ideal clustering model for text document using term frequency–inverse document frequency, which is considered as feature sets. Here, the initial centroid selection is much concentrated which can automatically cluster the text using weighted similarity measure in the proposed clustering process. In fact, the weighted similarity function involves the inter-cluster, and intra-cluster similarity of both ordered and unordered documents, which is used to minimize weighted similarity among the documents. An advanced model for clustering is proposed by the hybrid optimization algorithm, which is the combination of the Jaya Algorithm (JA) and Grey Wolf Algorithm (GWO), and so the proposed algorithm is termed as JA-based GWO. Finally, the performance of the proposed model is verified through a comparative analysis with the state-of-the-art models. The performance analysis exhibits that the proposed model is 96.56% better than genetic algorithm, 99.46% better than particle swarm optimization, 97.09% superior to Dragonfly algorithm, and 96.21% better than JA for the similarity index. Therefore, the proposed model has confirmed its efficiency through valuable analysis.
2D speckle tracking echocardiography as predictor of major adverse cardiac events (MACE) in patients with non ST elevation myocardial infarction and unstable angina
Authors: Lacanin MRA , Tucay EST 
Published: April 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

BACKGROUND
2D speckle strain echocardiography has been recognized in different studies to provide additional important prognostic information in patients with chronic stable coronary artery disease or acute coronary syndrome (ACS)—more often on (ST elevation myocardial infarction (STEMI) patients.

PURPOSE
This study aimed to determine the clinical utility of 2D speckle tracking echocardiography in predicting major adverse cardiac events (MACE) in patients with non ST elevation – acute coronary syndrome (NSTE-ACS).

METHODOLOGY
This is a prospective cohort study which included 91 patients diagnosed to have NSTE-ACS. Baseline characteristics were collected and echocardiographic evaluations of patients were done within 48 hours of admission. In hospital and 6 months MACE were evaluated in relation to their baseline echocardiographic parameters, 2D speckle strain and strain rate analyses.

RESULTS
Among the conventional echocardiographic parameters, only left ventricular end systolic diameter (LVESD) and wall motion score showed significant difference between those with and without outcomes after 6 months. There were no significant difference among the 2D speckle tracking strain and strain rate parameters between those patients with and without major cardiac events during their in hospital admission. However after 6 months follow-up, there were significantly lower mean left ventricular global longitudinal strain (GLS) (-14.22% ± 4.45 versus -16.44% ± 4.19, p-value 0.0261) and strain rate (-0.69 1/sec ± 0.36 versus -0.94 1/sec ± 0.25, p-value 0.009) were observed among patients with MACE compared to those without. Also, incidence of reduced GLS strain and strain rate, were significantly higher in those with MACE after 6 months. The left ventricular global circumferential strain and strain rate, and right ventricular global longitudinal strain did not have significant difference between those with and without but these had a generally lower value among those who had in-hospital and 6 months MACE. In this study, LV GLS sensitivity and specificity were 64.64% and 61.70% respectively, at cut-off value of &lt;-15.0% for detecting MACE within 6 month follow-up. LV GLS cut-off point &lt;-12.0%, which detects severe LV dysfunction in previous studies, have sensitivity of 40% but high specificity of 82.98% for predicting MACE after 6 months.

CONCLUSION
Both LV GLS strain and strain rate can be used to predict major adverse cardiovascular events after NSTE-ACS. Abstract Figure. ROC curve LV strain and strain rate
Medium-term prognostic value of angio-TC in type 2 diabetic patients without known cardiopathy
Authors: Garcia-Bellon AM , Gonzalez Gonzalez AM , Lara-Garcia C , Vivancos-Delgado V 
Published: April 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introdution
The use of coronary angiography by cardiac CT for the active search for coronary disease in asymptomatic diabetic patients is not generally indicated. On the other hand, in the case of high-risk patients with a high calcium score, there are results that do show a potential benefit of expanding the study with CT coronary angiography.

Purpose
The aim was to determine the medium-term prognostic value of computed tomography non-invasive coronary angiography (CT angiography) to predict major cardiac events in type 2 diabetic patients (p) without previous cardiac symptoms

Methods
Observational and prospective study in diabetic patients without symptoms suggestive of coronary heart disease (CHD), derived from performing a CT in the previous 5 years, for different reasons, not related to acute coronary syndrome. The presence of CHD was analyzed, as well as the incidence for cardiac events during follow-up.

Results
402 diabetic patients, mean evolution time of the disease: 6.8 +/- 2.1 years, mean Hb1Ac 8.1 +/- 0.7%. 60% of patients were male. Regarding other cardiovascular risk factors: 66.3% were hypertensive. 58.8% dyslipidemic. 26.3% obese. 27.5% smokers. 32.5% ex-smokers. 36.3% had a family history of CHD. Most frequent indication for CT: CHD screening, with previous inconclusive tests (26.3%), followed by pre-surgery evaluation (25%). Agatston Score 278.3 ± 235.8, Agatston Score&gt; 400 132 (32.8%), significant CHD 174 (43.2%), Vulnerable plaques 84 (20.9%)
The average follow-up was 5 years (+/- 1.3); 90 p (22.3%) suffered cardiac events (63 cardiac deaths, 27 non-fatal myocardial infarction). Best correlation with events was observed with the presence of significant coronary disease (ostruction&gt; 50%) compared to the Agatston score and the presence of vulnerable plaques (adjusted c-index of 0.59 versus univariate c-index of 0.42, respectively)
The annual event rate for patients with normal coronary arteries was 1.8%, which translated into a 5-year event-free survival period.
The highest annual event rate of 22.3% was detected in patients with obstructive 3-vessel CAD

Conclusions
Non-invasive CT angiography allows, after quantifying plaque severity in diabetic patients, to reclassify patients at high / very high risk
Diabetic patients with normal coronary arteries on CT angiography had a 5-year survival period free of major cardiac events.
Association of ADRB1 gene polymorphism with dilated cardiomyopathy
Authors: Chernova A , Nikulina SY , Kuznecova OO 
Published: April 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Aim
To evaluate the Association of rs1801252 polymorphism of the ADRB1 gene with dilated idiopathic cardiomyopathy (DCMP) and myocardial dilation of ischemic origin (DMI).

Subjects and methods
The study included patients with ICMP and MD IG in the number of 221 people. The average age of the subjects was in the range of 55.30 ± 9.69 years.
We divided the patients into 2 groups: the first – patients diagnosed with idiopathic dilatation cardiomyopathy and the second-patients with myocardial dilatation of ichemic origin. The number of patients in the first group was 111, including 99 men (89.2%) and 12 women (10.8%). The average age of patients in this group is 51.73 ± 9.74 years, in men 51.00 ± 8.96 years, in women 57.75 ± 3.71 years.
The second group included patients with myocardial dilatation of ischemic origin. Their number is 110 people, including 100 men (91.5%) and 10 women (8.5%). The average age of respondents is 58.68 ± 8.38 years, for men 58.29 ± 8.46 years, for women 62.90 ± 6.29 years.
The control group included patients who had no manifestations of cardiovascular diseases. Their number is 121 people (average age 53.6 ± 4.8 years).
The patients underwent laboratory and instrumental studies, as well as molecular and genetic studies of the A145G polymorphism of the ADRB1 gene (rs1801252 ). All patients underwent coronary angiography. Based on the anamnesis data and instrumental studies, those patients who could be said to have no risk factors for the development of dilatation of the heart cavities were identified in the first group. And those patients who were reliably diagnosed with CHD were in the second group, that is, dilatation of the heart cavities is due to a previous myocardial infarction, existing angina pectoris.

Results
In the group with DCMP 70.3% of patients were carriers of the common homozygous A145A genotype, the heterozygous A145G genotype-27.0%, and the rare homozygous G145G genotype-2.7%. In the control group 71.9% of patients were identified as carriers of a homozygous genotype by a common allele, and 25.3% were carriers heterozygous genotype, and homozygous genotype for a rare allele – 2.7%. Statistical analysis showed no achievement of statistical significance level across any of the genotypes. In the group with DM IG, there was no association with the rs1801252 polymorphism of the ADRB1 gene.

Conclusion
A statistically significant association of rs1801252 of the ADRB1 gene with DCMP was not found. The association of DM IG c rs1801252 could not be confirmed.
Iatrogenic bradyarrhythmia: previous conduction disturbances predicted need for permanent pacing
Authors: Esteves AF , Parreira L , Marinheiro R , Fonseca M , Farinha JM , Pinheiro A , Ferreira J , Mesquita D , Amador P , Lopes A , Fonseca N , Caria R 
Published: April 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
In bradyarrhythmia due to negative chronotropic medication, the need for permanent pacing after drug discontinuation is not always straightforward.

Purpose
Evaluate prevalence and predictors of the need of permanent pacing in patients with symptomatic bradyarrhythmia under negative chronotropic drugs.

Methods
We retrospectively studied patients admitted to the emergency room between January 2012 and December 2018 with symptomatic bradyarrhythmia who were under negative chronotropic drugs. We analysed patient demographic factors, previous medical history or electrocardiographic abnormalities and concomitant drugs. We evaluated the laboratory results, electrocardiographic and echocardiographic parameters at admission. During follow-up we analysed mortality, re-hospitalizations and device implantation. We used cox regression to assess the predictors of device implantation.

Results
85 patients, were admitted to the emergency room, 47% male, median age 81 (76-87) years.
The majority of patients (39, 46%) were admitted with syncope/presyncope and presented with complete AV block (62 patients, 73%). 54% had previous bundle branch block and most (69%) were taking beta blockers. Of note, 17 (20%) presented with ionic disturbances.
17 (20%) patients needed temporary pacing and 60 (71%) patients needed permanent pacing, implanted during index-hospitalization in 78 (92%) patients. Intra-hospital mortality was 5%.
During a median follow-up of 66 months, 31 (36%) patients were re-hospitalized and 7 (8%) needed device implantation. Global mortality was 26%.
In univariate analysis, previous bundle branch block predicted the need for permanent pacing, while presence of atrial fibrillation, antipsychotic/antidepressant use, acute kidney failure and hypo/hyperkalaemia precluded its requirement.
In multivariate analysis, previous bundle branch block was the only independent predictor of the need for permanent pacing.

Conclusion
In this group of patients with iatrogenic symptomatic bradyarrhythmia, the need for permanent pacing was independently associated with the presence of previous conduction disturbances. Univariate analysisHR (95% CI), p-valueMultivariate analysisHR (95% CI), p-valueAge in years0.987 (0.959-1.016), 0.3330.988 (0.955-1.024), 0.514Previous bundle branch block2.197 (1.137-4.246), 0.0192.081 (1.042-4.156), 0.038Previous atrial fibrillation0.559 (0.321-0.974), 0.0400.903 (0.491-1.662), 0.743Use of antipsychotic/antidepressant drugs0.429 (0.202-0.908), 0.0270.717, (0.276-1860), 0.494Acute kidney failure0.500 (0.281-0.889), 0.0180.950, (0.455-1.984), 0.891Hypo/hyperkalaemia0.359 (0.163-0.792), 0.0110.470, (0.172-1.288), 0.142