bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duffing-type oscillator under harmonic excitation with a variable value of excitation amplitude and time-dependent external disturbances
Authors: Wawrzynski Wojciech 
Published: February 2021

AbstractFor more complex nonlinear systems, where the amplitude of excitation can vary in time or where time-dependent external disturbances appear, an analysis based on the frequency response curve may be insufficient. In this paper, a new tool to analyze nonlinear dynamical systems is proposed as an extension to the frequency response curve. A new tool can be defined as the chart of bistability areas and area of unstable solutions of the analyzed system. In the paper, this tool is discussed on the basis of the classic Duffing equation. The numerical approach was used, and two systems were tested. Both systems are softening, but the values of the coefficient of nonlinearity are significantly different. Relationships between both considered systems are presented, and problems of the nonlinearity coefficient and damping influence are discussed.
Risk factors associated with failure of total ankle arthroplasty: a nationwide cohort study
Authors: Suh Dong Hun , Han Kyungdo , Lee Jin Woo , Kim Hak Jun , Kim Bongsung , Koo Bong Mo , Kim Hak Kyu , Choi Gi Won 
Published: February 2021

AbstractWe conducted a nationwide population-based cohort study to identify the risk factors associated with failure of total ankle arthroplasty (TAA). We included 2,914 subjects who underwent primary TAA between January 1, 2010, and December 31, 2016, utilizing the database of the Korean National Health Insurance Service. Failure of TAA was defined as revision TAA or arthrodesis procedures. An increased risk of TAA failure was observed in the < 65 age group versus the ≥ 75 age group [adjusted hazard ratios (aHR) 2.273, 95% confidence interval (CI) 1.223–4.226 in the 60–64 age group; aHR 2.697, 95% CI 1.405–5.178 in the 55–59 age group; aHR 2.281, 95% CI 1.145–4.543 in the 50–54 age group; aHR 2.851, 95% CI 1.311–6.203 in the < 50 age group]. Conversely, the ≥ 65 age group displayed no increase in the risk of TAA failure. The risk of TAA failure was increased in the severely obese group with body mass index (BMI) of ≥ 30 kg/m2 versus the normal BMI group (aHR 1.632; 95% CI 1.036–2.570). This population-based longitudinal study demonstrated that age < 65 years and BMI of ≥ 30 kg/m2 were associated with increased risk of TAA failure.
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
Authors: Bell Steven , Rigas Andreas S. , Magnusson Magnus K. , Ferkingstad Egil , Allara Elias , Bjornsdottir Gyda , Ramond Anna , Sørensen Erik , Halldorsson Gisli H. , Paul Dirk S. , Burgdorf Kristoffer S. , Eggertsson Hannes P. , Howson Joanna M. M. , Thørner Lise W. , Kristmundsdottir Snaedis , Astle William J. , Erikstrup Christian , Sigurdsson Jon K. , Vuckovic Dragana , Dinh Khoa M. , Tragante Vinicius , Surendran Praveen , Pedersen Ole B. , Vidarsson Brynjar , Jiang Tao , Paarup Helene M. , Onundarson Pall T. , Akbari Parsa , Nielsen Kaspar R. , Lund Sigrun H. , Juliusson Kristinn , Magnusson Magnus I. , Frigge Michael L. , Oddsson Asmundur , Olafsson Isleifur , Kaptoge Stephen , Hjalgrim Henrik , Runarsson Gudmundur , Wood Angela M. , Jonsdottir Ingileif , Hansen Thomas F. , Sigurdardottir Olof , Stefansson Hreinn , Rye David ,   DBDS Genomic Consortium,   Denmark, Andersen Steffen , Burgdorf Kristoffer , Jemec Gregor , Jennum Poul , Johansson Pär , Nielsen Kasper R. , Nyegaard Mette , Petersen Mikkel , Werge Thomas ,   Iceland, Stefánsson Hreinn , Thorsteinsdóttir Unnur , Peters James E. , Westergaard David , Holm Hilma , Soranzo Nicole , Banasik Karina , Thorleifsson Gudmar , Ouwehand Willem H. , Thorsteinsdottir Unnur , Roberts David J. , Sulem Patrick , Butterworth Adam S. , Gudbjartsson Daniel F. , Danesh John , Brunak Søren , Di Angelantonio Emanuele , Ullum Henrik , Stefansson Kari 
Published: February 2021

AbstractIron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.
Study on cost Control of small and Medium-sized Enterprises under the background of “Internet +” — Take Company T as an example
Authors: Gao Hui 
Published: February 2021

At present, China has officially entered the “Internet +” era, the development of the Internet economy makes China’s traditional manufacturing enterprises enter a new stage of development. Due to their low product value and high cost, the price competition among small and medium-sized manufacturing enterprises is increasingly fierce. Therefore, it is more and more important for enterprise survival and development to continuously promote enterprise performance growth, expand enterprise profit space, strengthen cost control and improve capital utilization rate.
In this paper, T Company is selected to study related issues of cost control of small and medium-sized enterprises(SMES), analyze the current situation and existing problems of cost control of T company, and combine with the background of “Internet +”, propose optimization Suggestions of cost control of T Company.
La technologie de l’enrichissement de l’uranium au service de la production d’isotopes stables
Authors: Bigot Laurent 
Published: February 2021

La radioactivité en général, certains isotopes en particulier, sont de plus en plus utilisés dans le domaine médical pour détecter des maladies et contribuer à en guérir.
Orano Chimie Enrichissement est également en passe de se mettre au service de nouveaux secteurs dont le médical, en produisant des isotopes stables.
Rural Tourism within the Sustainable Development Goals: the Case of Ukraine
Authors: Shevchenko Hanna , Petrushenko Mykola 
Published: February 2021

Research background: rural tourism is an economic and environmental activity that fits harmoniously into the concept of sustainable and inclusive development. In Ukraine, it is called rural green tourism, but in practice not all aspects of it can meet the Sustainable Development Goals 2030.
Purpose of the article: to analyze the relationship between the structures of the rural tourism goals and the SDGs, to demonstrate the evolution, possibilities of the development on the example of Ukraine’s rural tourism, especially in the framework of the European Green Deal.
Methods: factor analysis – when studying the structure of the rural tourism goals and the factors that affect it, as well as when comparing it with the structure of other sustainable activities; elements of graph theory – in the graphical analysis of the Sustainable Development Goals decomposition in their projection into the plane of rural tourism.
Findings & Value added: the structure of the rural green tourism goals in Ukraine have been harmonized with the Sustainable Development Goals 2030. Sustainability factors have been identified that allow the tourism and recreation sphere in the medium and long term perspective not only to form a competitive market for relevant services, but also to serve as an important component of the inclusive development. Factors of tourism sphere transformation due to the coronavirus pandemic are taken into consideration. The concept of the phased programming in sphere of rural tourism in Ukraine within the framework of the European Green Deal 2030 and 2050 has been improved.
Considerations regarding the risk of integrity – Romanian developments within the European framework
Authors: Mieilă Mihai , Vlad (Vasile) Georgiana , Sima (Niţoi) Alexandra , Necula Anda-Ileana , Bărbulescu (Niţa) Mirela Roxana , Iancu Florian 
Published: February 2021

In the process of risk management process implementation and deployment within the organizations, both public and private, the applicable standards outline the role played the human resources, as the key issue in this respect. Following the standards and the practice in the field, the integrity risks are considered within the framework of a holistic approach. The paper tries to introduce and address the main features of the integrity risks, considering the European approach, based on the quantitative and qualitative measurement through some specific indicators. Besides, the joint-approaches of the developments in the legal framework, and the other international bodies involved in regulation of the field, namely the Organization for Economic Cooperation and Development and the United Nations Convention against Corruption are outlined. In addition, the public perception indicators regarding the integrity are presented through the comparative examination of the local findings amongst the other European countries and averages, pointing out the specific evolutions. The conclusions highlight the favourable changes and some of the actions required as prerequisites for necessary further improvements.
Research background: Defined as the abuse of power oriented towards gain of private benefits, the corruption is a phenomenon that affects the economies and the fair distribution of welfare. Although there is a regulatory framework both at national and international levels, measuring of corruption remains a difficult task, as it often relies on public perception.
Purpose of the article: The objectives consist in identification and assessment of integrity risks, besides the implementation of the adequate control tools, in order to ensure their proper monitoring.
Methods: Employing the data from the international surveys and indexes used in measurement of the corruption perception, and considering the applicable legal framework, there are examined both the specific trends in Romania, compared to the general developments in the European Union .
Findings Value added: Amid a general improvement trend, there are highlighted some slight backward steps and the necessary actions for future improvements. Considering the weak parts specific to the perception surveys, besides their further usage, results the necessity of fostering the using of special designed indexes, which rely, in addition, on aspects that mainly remain out of public perception.
SMART VILLAGE – smart solution for sustainable development in the South East Region
Authors: Liviu Marian Dobrotă , Serban Mădălina , Mogildea Ina , Turek Rahoveanu Maria Magdalena 
Published: February 2021

Research background. An intelligent rural community in our vision wants to be a balance between people and the environment, through a transformation of long-term economic, social and environmental characteristics. This paper aims to investigate the need to change this environment in the South-East Region, Romania, a rural plain.
Purpose of the article. Villages with a certain risk of poverty are most at risk of depopulation due to the presence of low-income people, disadvantaged groups, with a population of "third age" and "fourth age". In other mountain areas, for example, there are rich villages where aging does not characterize low-income people and retired migrants.
Methods. The objectives of the research are to describe the Chiscani, Brăila area, the need to transform the villages in its composition, but also to identify activities with potential for sustainable development at its level. Awareness of the community by promoting those economic activities that support the smart plain area is the basis of the whole concept.
Findings & Value added. The aim of this study is to evaluate the perceptions about smart village (SV) to attract entrepreneurs, tourists and business development in the South East Region, Chiscani.
Der Einfluss von Gewinnung und Verarbeitung auf das Regenerationspotenzial von Fettstammzellen und die Adipozytenvitalität
Authors: Klietz Marie-Luise , Kückelhaus Maximilian , Wiebringhaus Philipp , Raschke Michael J. , Hirsch Tobias , Aitzetmüller Matthias M. 
Published: February 2021

ZusammenfassungDer autologe Lipotransfer stellt eine etablierte Innovation der Plastischen Chirurgie dar. Als Methode zur Mammarekonstruktion und -augmentation bietet er eine klinisch immer bedeutender werdende Alternative zu den konventionellen Verfahren wie der Lappenchirurgie oder der Verwendung von Silikonimplantaten.Der Erfolg oder Misserfolg des autologen Lipotransfers hängt größtenteils vom Überleben der im Fett befindlichen Fettstammzellen ab.Diese Überlebensrate ist wiederum von einem komplexen Zusammenspiel der Zwischenschritte bei der Fettabsaugung und potenzieller Aufbereitung des Fettgewebes abhängig.Dieses Review beleuchtet die entscheidenden Prinzipien zur Erzielung optimaler Ergebnisse.
Diabetes Care During COVID-19 Pandemic in Singapore Using a Telehealth Strategy
Authors: Lian Xia , Dalan Rinkoo , Seow Cherng Jye , Liew Huiling , Jong Michelle , Chew Daniel , Lim Brenda , Lin Anita , Goh Eunice , Goh Christina , Othman Noorani Bte , Tan Lucy , Boehm Bernhard O. 
Published: February 2021

AbstractSingapore currently has one of highest number of confirmed COVID-19 cases in Southeast Asia. To curb the further spread of COVID-19, Singapore government announced a temporary nationwide lockdown (circuit breaker). In view of restrictions of patients’ mobility and the enforcement of safe distancing measures, usual in-person visits were discouraged. Here we describe how diabetes care delivery was ad hoc redesigned applying a telehealth strategy. We describe a retrospective assessment of subjects with diabetes, with and without COVID-19 infection, during the circuit breaker period of 7th April to 1st June 2020 managed through Tan Tock Seng Hospital’s telehealth platform. The virtual health applications consisted of telephone consultations, video telehealth visits via smartphones, and remote patient monitoring. The TTSH team intensively managed 298 diabetes patients using a telehealth strategy. The group comprised of (1) 84 inpatient COVID-19 patients with diabetes who received virtual diabetes education and blood glucose management during their hospitalisation and follow-up via phone calls after discharge and (2) 214 (n=192 non-COVID; n=22 COVID-positive) outpatient subjects with suboptimal glycaemic control who received intensive diabetes care through telehealth approaches. Remote continuous glucose monitoring was applied in 80 patients to facilitate treatment adjustment and hypoglycaemia prevention. The COVID-19 pandemic situation mooted an immediate disruptive transformation of healthcare processes. Virtual health applications were found to be safe, effective and efficient to replace current in-person visits.
Favorable effect of endoscopic reassessment of clinically staged T2 esophageal adenocarcinoma: a multicenter prospective cohort study
Authors: van de Ven Steffi E. M. , Spaander Manon C. W. , Pouw Roos E. , Tang Thjon J. , Houben Martin H. M. G. , Schoon Erik J. , de Jonge Pieter J. F. , Bruno Marco J. , Koch Arjun D. 
Published: February 2021

Abstract
Background Clinical tumor stage of esophageal adenocarcinoma (EAC) is determined by endoscopic ultrasound and/or computed tomography scan, which have low accuracy for stages T1 and T2, potentially leading to overtreatment. We aimed to assess the proportion of cT2 EACs downstaged to cT1 after endoscopic reassessment (ERA) by an experienced interventional endoscopist.
Methods We performed a prospective multicenter cohort study. Patients with cT2N0M0 EAC were included and underwent ERA. The primary outcome was proportion of cT2 EACs downstaged to cT1 after ERA.
Results 15/25 included patients (60 %) were downstaged from cT2 to cT1 EAC after ERA and underwent attempted endoscopic resection. Endoscopic resection was aborted in 3/15 patients because of tumor invasion into the muscle layer; all three underwent successful surgical resection. Endoscopic resection was successful in 12/15 patients (80 %), all of whom had pT1 tumors. Overall, 10/25 (40 %) were treated with endoscopic resection alone.
Conclusions ERA downstaged about half of the cT2 tumors to cT1, rendering them suitable for endoscopic resection. ERA had substantial clinical impact on therapeutic management, preventing overtreatment in 40 % of patients.
Cost Effectiveness of Whole Exome Sequencing for Children with Developmental Delay in a Developing Country: A Study from Jordan
Authors: Masri Amira , Hamamy Hanan 
Published: February 2021

AbstractThis retrospective study aimed to determine the cost effectiveness of whole exome sequencing (WES) in the diagnosis of children with developmental delay in a developing country. In this study of 40 patients, the average cost of traditional investigations and indirect costs related to rehabilitation and medications per child were USD847 and 6,585 per year, respectively. With a current cost for WES of approximately USD1,200, we concluded that performing WES could be cost effective, even in countries with limited resources, as it provides the option for genetic counseling in affected families with an ultimate reduction of overall financial burden to both parents and health care system.
A proton beam energy modulator for rapid proton therapy
Authors: Lu Xueying , Li Zenghai , Dolgashev Valery , Bowden Gordon , Sy Ann , Tantawi Sami , Nanni Emilio A. 
Published: February 2021

We present the design for a rapid proton energy modulator with radiofrequency accelerator cavities, which can deliver the proton radiation dose to varied depth in human tissues much faster than traditional mechanical beam energy degraders. The proton energy modulator is designed as a multi-cell 1-m long accelerator working at 2.856 GHz. Each individual accelerator cavity is powered by a 400 kW compact klystron to provide an accelerating/decelerating gradient of 30 MV/m. The high gradient is enabled by the individual power coupling regime, which provides a high shunt impedance. Beam dynamics simulations were performed, showing that the energy modulator can provide ±30 MeV of beam energy change for a 150 MeV, 7 mm long (full length) proton bunch, and the total energy spread of 3 MeV is satisfactory to clinical needs. A prototype experiment of a single cell has been built and tested, and the low-power microwave measurement results agree very well with simulations. The energy modulator is optimized for the 150 MeV cyclotron proton beam, while this approach can work with different beam energies.
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort
Authors: Néant Nadège , Lingas Guillaume , Le Hingrat Quentin , Ghosn Jade , Engelmann Ilka , Lepiller Quentin , Gaymard Alexandre , Ferré Virginie , Hartard Cédric , Plantier Jean-Christophe , Thibault Vincent , Marlet Julien , Montes Brigitte , Bouiller Kevin , Lescure François-Xavier , Timsit Jean-François , Faure Emmanuel , Poissy Julien , Chidiac Christian , Raffi François , Kimmoun Antoine , Etienne Manuel , Richard Jean-Christophe , Tattevin Pierre , Garot Denis , Le Moing Vincent , Bachelet Delphine , Tardivon Coralie , Duval Xavier , Yazdanpanah Yazdan , Mentré France , Laouénan Cédric , Visseaux Benoit , Guedj Jérémie ,   for the French COVID Cohort Investigators and French Cohort Study groups
Published: February 2021

SignificanceA detailed characterization of viral load kinetics and its association with disease evolution is key to understand the virus pathogenesis, identify high-risk patients, and design better treatment strategies. We here analyze the mortality and the virological information collected in 655 hospitalized patients, including 284 with longitudinal measurements, and we build a mathematical model of virus dynamics and survival. We predict that peak viral load occurs 1 d before symptom onset, on average, and that dynamics of decline after peak is slower in older patients. Viral load dynamics after hospital admission is an independent predictor of the risk of death, suggesting that prolonged viral shedding of high quantities of virus is associated with poor outcome in this population.
Learning from an avatar video instructor
Authors: Vest Nicholas A. , Fyfe Emily R. , Nathan Mitchell J. , Alibali Martha W. 
Published: February 2021

Abstract
Teachers often produce gestures, and, in some cases, students mimic their teachers’ gestures and adopt them into their own repertoires. However, little research has explored the role of gesture mimicry in technology-based learning contexts. In this research, we examined variations in the rate and form of students’ gestures when learning from a computer-animated pedagogical avatar. Twenty-four middle school students received a lesson on polynomial multiplication from a gesturing avatar video instructor. After the lesson, students were asked to provide an explanation of what they learned. Students varied in their gesture rates, and some students produced gestures that were similar in form to the avatar’s gestures. Students who produced gestures that aligned with the teacher’s gestures scored higher than those who did not produce such gestures. These results suggest that middle school students’ gestures play a key role when learning a mathematics lesson from an avatar instructor.
“When you were that little…”
Authors: Safar Josefina 
Published: February 2021

Abstract
In this article, I analyse how conventional height-specifier gestures used by speakers of Yucatec Maya become
incorporated into Yucatec Maya Sign Languages (YMSLs). Combining video-data from elicitation, narratives, conversations and
interviews collected from YMSL signers from four communities as well as from hearing nonsigners from another Yucatec Maya village,
I compare form, meaning and distribution of height-specifiers in gesture and sign. Co-speech gestures that depict the height of
upright entities – performed with a flat hand, palm facing downwards – come to serve various linguistic functions in YMSLs: a noun
for human referents, a verb GROW, a spatial referential device, and an element of name signs. Special attention is paid to how
height-specifier gestures fulfil a grammatical purpose as noun-classifiers for human referents in YMSLs. My study demonstrates
processes of lexicalisation and grammaticalisation from gesture to sign and discusses the impact of gesture on the emergence of
shared sign languages.