bluuebunny/crossref_metadata_2025_split huggingface dataset:
The global Alzheimer's Association round robin study on plasma amyloid β methods
Authors: Pannee Josef , Shaw Leslie M. , Korecka Magdalena , Waligorska Teresa , Teunissen Charlotte E. , Stoops Erik , Vanderstichele Hugo M. J. , Mauroo Kimberley , Verberk Inge M. W. , Keshavan Ashvini , Pesini Pedro , Sarasa Leticia , Pascual‐Lucas Maria , Fandos Noelia , Allué José‐Antonio , Portelius Erik , Andreasson Ulf , Yoda Ritsuko , Nakamura Akinori , Kaneko Naoki , Yang Shieh‐Yueh , Liu Huei‐Chun , Palme Stefan , Bittner Tobias , Mawuenyega Kwasi G. , Ovod Vitaliy , Bollinger James , Bateman Randall J. , Li Yan , Dage Jeffrey L. , Stomrud Erik , Hansson Oskar , Schott Jonathan M. , Blennow Kaj , Zetterberg Henrik 
Published: October 2021

AbstractIntroductionBlood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)–based assays currently used in clinical settings. In this study, we examined different blood‐based assays to measure Aβ and how they compare among centers and assays.MethodsAliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass‐spectrometric methods were used to measure plasma Aβ concentrations.ResultsCorrelations were weak for Aβ42 while Aβ40 correlations were stronger. The ratio Aβ42/Aβ40 did not improve the correlations and showed weak correlations.DiscussionThe poor correlations for Aβ42 in plasma might have several potential explanations, such as the high levels of plasma proteins (compared to CSF), sensitivity to pre‐analytical sample handling and specificity, and cross‐reactivity of different antibodies. Different methods might also measure different pools of plasma Aβ42. We, however, hypothesize that greater correlations might be seen in future studies because many of the methods have been refined during completion of this study.
Early resources lead to persistent benefits for bumble bee colony dynamics
Authors: Malfi Rosemary L. , Crone Elizabeth , Rundlöf Maj , Williams Neal M. 
Published: October 2021

AbstractConditions experienced early in development can affect the future performance of individuals and populations. Demographic theories predict persistent population impacts of past resources, but few studies have experimentally tested such carry‐over effects across generations or cohorts. We used bumble bees to test whether resource timing had persistent effects on within‐colony dynamics over sequential cohorts of workers. We simulated a resource pulse for field colonies either early or late in their development and estimated colony growth rates during pulse‐ and non‐pulse periods. During periods when resources were not supplemented, early‐pulse colonies grew faster than late‐pulse colonies; early‐pulse colonies grew larger as a result. These results revealed persistent effects of past resources on current growth and support the importance of transient dynamics in natural ecological systems. Early‐pulse colonies also produced more queen offspring, highlighting the critical nature of resource timing for the population, as well as colony, dynamics of a key pollinator.
Does crossing a moral line justify collective means? Explaining how a perceived moral violation triggers normative and nonnormative forms of collective action
Authors: Pauls Inga L. , Shuman Eric , van Zomeren Martijn , Saguy Tamar , Halperin Eran 
Published: October 2021

AbstractIn three studies conducted in the United States, we examined whether a perceived moral violation motivates willingness to engage in normative and more radical collective action. Using value‐protection and identity‐formation models, we explored whether increased endorsement of moral convictions and relevant opinion‐based group identification could explain such effects. Study 1, using the “travel ban” for Muslims as the focal issue, experimentally found that a strong violation, compared to a weak violation, increased normative and nonnormative collective action, moral convictions and opinion‐based group identification. Study 2 replicated these results in a longitudinal design and supported a mediating effect of increased endorsement of moral convictions and opinion‐based group identity. Study 3 used a real‐world violation (the United States’ withdrawal from the Paris climate agreements) to replicate the findings cross‐sectionally. We conclude that a perceived moral violation motivates normative and nonnormative collective action because the violation makes one's moral conviction and opinion‐based group identification more salient.
Resorcinol/Formaldehyde polymer derived carbon protected CoSe2 nanocubes: A non‐precious, efficient, and durable electrocatalyst for oxygen evolution reaction
Authors: Bhowmik Koushik , Dutta Anirban , Vyas Mukesh Kumar , Ota Jyotiranjan , Hait Samik Kumar , Kagdiyal Vivekananda , Saxena Deepak , Ramakumar Satya Sai Venkata 
Published: October 2021

AbstractComposite nanostructured materials are attractive for electrochemical water‐splitting applications. In this work, cube‐shaped nanostructured CoSe2 were synthesized by a template‐assisted method, where Zeolitic Imidazole Framework (ZIF67) was used as a template. Initially, the template was observed with a cube shape, but the structure disintegrated on selenization. The introduction of Resorcinol/Formaldehyde (RF) polymer leads to stabilization of the cube shape and also coated the nanocubes with conductive carbon support. Due to the high surface area of the hollow structure and conductive coating, the CoSe2/C provided an excellent electrocatalytic activity for oxygen evolution reaction (OER). CoSe2/C delivered an overpotential of 290 mV with good cycling stability at a current density of 10 mA/cm2 in 1 M KOH aqueous solution, suggesting the possibility of being used as an electrochemical catalyst for oxygen evolution reaction.
When discomfort enters our skin: Five feminists in conversation
Authors: García‐González Andrea , Hoover Elona Marjory , Francis Athanasia (Nancy) , Rush Kayla , Angel Ana María Forero 
Published: October 2021

AbstractCreated around, through and within discomfort, this piece weaves together the voices of five feminist scholars in an exploration of troubling affective and emotional experiences, offering material for critical theorizing and engaged scholarship. This inquiry started at a conference panel in July 2019. Taking on the invitation made by the editors ofFeminist Anthropologyfor the five of us to write in conversation, this piece also responds to April Petillo's piece in the first issue of this journal where she compelled us, feminist anthropologists, to listen through discomfort in order to challenge hierarchies of power and knowledge production. Through a polyphonic composition that draws on the different backgrounds, research and life trajectories of five feminist scholars through a collective online writing process, this piece purposefully plays with form, presenting reflections on naming relational discomforts, unsettling academic affects with our writing, violence, precarity and privilege, and how to work with discomfort through feminist solidarity.
Bakshi, Kapadia, and Madan (2003) risk‐neutral moment estimators: An affine jump‐diffusion approach
Authors: Aschakulporn Pakorn , Zhang Jin E. 
Published: October 2021

AbstractThis is the first study of the errors in the Bakshi, Kapadia, and Madan risk‐neutral moment estimators under the Duffie, Pan, and Singleton affine jump‐diffusion model benchmarked against their true values. This is accomplished by extending the exact solutions from Zhen and Zhang. To mitigate errors in skewness, interpolating the implied volatility curve linearly and applying constant extrapolation to have a step size of $1 and strikes ranging from a quarter to quadruple the forward price should yield skewness values with errors less than , based on simulated data using parameters calibrated with the S&P 500 index during 2020.
Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments
Authors: Kurebayashi Yutaka , Matsuda Kosuke , Ueno Akihisa , Tsujikawa Hanako , Yamazaki Ken , Masugi Yohei , Kwa Wit Thun , Effendi Kathryn , Hasegawa Yasushi , Yagi Hiroshi , Abe Yuta , Kitago Minoru , Ojima Hidenori , Sakamoto Michiie 
Published: October 2021

Abstract

Background and Aims
Immune cells and tumor vessels constitute important elements in tumor tissue; however, their detailed relationship in human tumors, including HCC, is still largely unknown. Consequently, we expanded our previous study on the immune microenvironment of HCC and analyzed the relationship among the immune microenvironment, inflammatory/angiostatic factor expression, angiogenic factor expression, and tumor vessel findings, including vessels encapsulating tumor clusters (VETC) and macrotrabecular‐massive (MTM) patterns.

Approach and Results
We classified HCC into four distinct immunovascular subtypes (immune‐high/angiostatic [IH/AS], immune‐mid/angio‐mid [IM/AM], immune‐low/angiogenic [IL/AG], and immune‐low/angio‐low [IL/AL]). IH/AS, IM/AM, and IL/AG subtypes were associated with decreasing lymphocytic infiltration and increasing angiogenic factor expression and VETC/MTM positivity, reflecting their reciprocal interaction in the tumor microenvironment of HCC. IL/AG subtype was further characterized by CTNNB1 mutation and activation of Wnt/β‐catenin pathway. IL/AL subtype was not associated with increased lymphocyte infiltration or angiogenic factor expression. Prognostically, IH/AS subtype and VETC/MTM positivity were independently significant in two independent cohorts. Increased angiogenic factor expression was not necessarily associated with VETC/MTM positivity and poor prognosis, especially when inflammatory/angiostatic milieu coexisted around tumor vessels. These results may provide insights on the therapeutic effects of immunotherapy, antiangiogenic therapies, and their combinations. The potential of evaluating the immunovascular microenvironment in predicting the clinical effect of these therapies in nonresectable HCC needs to be analyzed in the future study.

Conclusions
HCC can be classified into four distinct immunovascular subtypes (IH/AS, IM/AM, IL/AG, and IL/AL) that reflect the reciprocal interaction between the antitumor immune microenvironment and tumor angiogenesis. In addition to its clinicopathological significance, immunovascular classification may also provide pathological insights on the therapeutic effect of immunotherapy, antiangiogenic therapy, and their combination.
Measuring quality of pre‐hospital traumatic shock care—development and validation of an instrument for resource‐limited settings
Authors: Mould‐Millman Nee‐Kofi , Dixon Julia , Lee Michael , Meese Halea , Mata Lina V. , Burkholder Taylor , Moreira Fabio , Bester Beatrix , Thomas Jacob , de Vries Shaheem , Wallis Lee A. , Ginde Adit A. 
Published: October 2021

AbstractBackground and AimsImproving the quality of pre‐hospital traumatic shock care, especially in low‐ and middle‐income countries, is particularly relevant to reducing the large global burden of disease from injury. What clinical interventions represent high‐quality care is an actively evolving field and often dependent on the specific injury pattern. A key component of improving the quality of care is having a consistent way to assess and measure the quality of shock care in the pre‐hospital setting. The objective of this study was to develop and validate a chart abstraction instrument to measure the quality of trauma care in a resource‐limited, pre‐hospital emergency care setting.MethodsTraumatic shock was selected as the tracer condition. The pre‐hospital quality of traumatic shock care (QTSC) instrument was developed and validated in three phases. A content development phase utilized a rapid literature review and expert consensus to yield the contents of the draft instrument. In the instrument validation phase, the QTSC instrument was created and underwent end user and content validation. A pilot‐testing phase collected user feedback and performance characteristics to iteratively refine draft versions into a final instrument. Accuracy and inter‐ and intra‐rater agreement were calculated.ResultsThe final QTSC instrument contains 10 domains of quality, each with specific criteria that determine how the domain is measured and the level of quality of care rendered. The instrument is over 90% accurate and has good inter‐ and intra‐rater reliability when used by trained pre‐hospital provider users in South Africa. Pre‐hospital provider user feedback indicates the tool is easy to learn and quick to use.ConclusionWe created and validated a novel chart abstraction instrument that can reliably and accurately measure the quality of pre‐hospital traumatic shock care. We provide a systematic methodology for developing and validating a quality of care tool for resource‐limited care settings.
Subjective donor deferral as a tool for increased blood transfusion safety: A cross‐sectional observational study
Authors: de Moura Juliane Girão , Costa Bruno Almeida , Silva Fabiana Aguiar Carneiro , Fechine Francisco Vagnaldo , Macedo Ênio Simas , Barbosa José Lucio Jorge , Santos Franklin José Candido , de Francesco Daher Elizabeth , de Barros Carlos Luciana Maria , Brunetta Denise Menezes 
Published: October 2021

AbstractObjectivesThis study aims at evaluating whether subjective donor deferral (SDD) has the potential for increasing blood transfusion safety.BackgroundAppropriate donor selection via clinical and serologic screening is necessary to prevent transfusion‐transmissible infections (TTIs). One additional strategy adopted by some Brazilian blood transfusion centers (BTCs) is the rejection of a donation by the pre‐donation interviewer based on subjective factors.Methods/MaterialsWe conducted a STROBE‐guided cross‐sectional study including 105 005 prospective donors who presented to our BTC between 1 January 2013, and 31 December 2015. Donors were evaluated for age, gender, education level, donation type and history, confidential unit exclusion, SDD, and results of serologic screening for TTIs.ResultsEven after controlling for potential confounding variables, subjectively deferred donors were more likely to have at least one reactive serology in the standard screening (OR: 2.80; 95% CI: 2.13‐3.69; P < .001). They also had a higher risk for testing positive for syphilis (OR: 4.47; 95% CI: 3.05‐6.55; P < .001), hepatitis B (OR: 5.69; 95% CI: 2.48‐13.08; P < .001), and HIV (OR: 6.14; 95% CI: 3.22‐11.69; P < .001).ConclusionsRoutine implementation of SDD in donor selection may be an effective additional measure to avoid TTIs, highlighting the importance of interviewer experience, perspicacity, and face‐to‐face contact with donors for blood safety assurance.
Refugees in Brazil: An investigation of Syrian refugees' psychological experiences
Authors: Torres Cláudio V. , Safdar Saba , Oliveira Sérgio E. S. , Adaid‐Castro Breno G. , Faiad Cristiane , Rodrigues‐Marçulo Alexandra O. , Nofal Bayram 
Published: October 2021

Although there is a strong body of literature on the psychosocial distress of refugees from Global South to Global North, there is limited literature on refugees who migrate from Global South (i.e., Syria) to Global South (i.e., Brazil). The present study aims to investigate Syrian refugees in Brazil. Participants were 202 Syrians. Most respondents were men (62.9%), with an average age of 35.9 years old (SD = 11.13). Results suggest an effect of positive ethnic identity in psychological and physical distress, who also perceive more discrimination than individuals who negatively identify with their ethnicity. Structural equation model suggests the fit of the proposed mediation model. Our findings add to the much‐needed line of investigations examining Syrian refugees settling in Brazil.
Giant broad ligament leiomyoma with postoperative infection diagnosed with contrast‐enhanced ultrasound: Case report and literature review
Authors: Guo Li , Wang Mi Zhou , Wang Li Jing , Zang Ai Hua , Jia Dong Mei , Hou Lin , Zhang Ping 
Published: October 2021

AbstractA 33‐year‐old woman of giant broad ligament leiomyoma with myxoid degeneration was misdiagnosed as ovarian tumor. The patient underwent a transabdominal myomectomy and developed a pelvic infection after operation diagnosed with contrast‐enhanced ultrasound. She was cured and ultimately discharged after symptomatic treatment. Only 21 cases of giant broad ligament leiomyomas with a diameter larger than 12 cm were included. The present systematic review aimed to increase awareness of the clinical characteristics and treatment methods of giant broad ligament leiomyoma, and reduce the rates of misdiagnosis and postoperative complications.
Urinary extracellular vesicles: Assessment of pre‐analytical variables and development of a quality control with focus on transcriptomic biomarker research
Authors: Barreiro Karina , Dwivedi Om Prakash , Valkonen Sami , Groop Per‐Henrik , Tuomi Tiinamaija , Holthofer Harry , Rannikko Antti , Yliperttula Marjo , Siljander Pia , Laitinen Saara , Serkkola Elina , af Hällström Taija , Forsblom Carol , Groop Leif , Puhka Maija 
Published: October 2021

AbstractUrinary extracellular vesicles (uEV) are a topical source of non‐invasive biomarkers for health and diseases of the urogenital system. However, several challenges have become evident in the standardization of uEV pipelines from collection of urine to biomarker analysis. Here, we studied the effect of pre‐analytical variables and developed means of quality control for uEV isolates to be used in transcriptomic biomarker research. We included urine samples from healthy controls and individuals with type 1 or type 2 diabetes and normo‐, micro‐ or macroalbuminuria and isolated uEV by ultracentrifugation. We studied the effect of storage temperature (‐20°C vs. ‐80°C), time (up to 4 years) and storage format (urine or isolated uEV) on quality of uEV by nanoparticle tracking analysis, electron microscopy, Western blotting and qPCR. Urinary EV RNA was compared in terms of quantity, quality, and by mRNA or miRNA sequencing. To study the stability of miRNA levels in samples isolated by different methods, we created and tested a list of miRNAs commonly enriched in uEV isolates. uEV and their transcriptome were preserved in urine or as isolated uEV even after long‐term storage at ‐80°C. However, storage at ‐20°C degraded particularly the GC‐rich part of the transcriptome and EV protein markers. Transcriptome was preserved in RNA samples extracted with and without DNAse, but read distributions still showed some differences in e.g. intergenic and intronic reads. MiRNAs commonly enriched in uEV isolates were stable and concordant between different EV isolation methods. Analysis of never frozen uEV helped to identify surface characteristics of particles by EM. In addition to uEV, qPCR assays demonstrated that uEV isolates commonly contained polyoma viruses. Based on our results, we present recommendations how to store and handle uEV isolates for transcriptomics studies that may help to expedite standardization of the EV biomarker field.
Introduction of SARS‐CoV‐2 C.37 (WHO VOI lambda) in the Sao Paulo State, Southeast Brazil
Authors: Kashima Simone , Slavov Svetoslav N. , Giovanetti Marta , Rodrigues Evandra S. , Patané José S. L. , Viala Vincent L. , Santos Elaine V. , Evaristo Mariane , de Lima Loyze P. O. , Martins Antonio J. , dos Santos Barros Claudia R. , Marqueze Elaine C. , Garibaldi Pedro M. M. , Ferreira Natasha N. , Moraes Glenda R. , Brassaloti Ricardo A. , Cassano Raquel L. R. C. , Mariani Pilar D. S. C. , Kitajima João P. , Schlesinger David , Bezerra Rafael S. , Assato Patricia A. , da Costa Felipe A. S. , Poleti Mirele Daiana , Lesbon Jessika C. C. , Mattos Elisangela C. , Banho Cecilia A. , Sacchetto Lívia , Grotto Rejane M. T. , Souza‐Neto Jayme A. , Fonseca Vagner , de Alcantara Luiz C. J. , Nogueira Maurício L. , Fukumasu Heidge , Coutinho Luiz L. , Borges Marcos , Calado Rodrigo T. , Elias Maria C. , Sampaio Sandra C. , Covas Dimas T. 
Published: October 2021

AbstractThe Lambda variants of interest (VOI) (C37/GR/452Q.V1/21G) was initially reported in Lima, Peru but has gained rapid dissemination through other Latin American countries. Nevertheless, the dissemination and molecular epidemiology of the Lambda VOI in Brazil is unknown apart from a single case report. In this respect, we characterized the circulation of the SARS‐CoV‐2 Lambda VOI (C37/GR/452Q.V1/21G) in Sao Paulo State, Brazil. From March to June 2021, we identified seven Lambda isolates in a set of approximately 8000 newly sequenced genomes of the Network for Pandemic Alert of Emerging SARS‐CoV‐2 variants from Sao Paulo State. Interestingly, in three of the positive patients, the Lambda VOI infection was probably related to a contact transmission. These individuals were fully vaccinated to COVID‐19 and presented mild symptoms. The remaining positive for Lambda VOI individuals showed different levels of COVID‐19 symptoms and one of them needed hospitalization (score 5, WHO). In our study, we present a low level of Lambda VOI circulation in the Sao Paulo State. This reinforces the essential role of molecular surveillance for the effective SARS‐CoV‐2 pandemic response, especially in regard to circulating variants.
Covid‐19 sequelae in working age patients: A systematic review
Authors: d'Ettorre Gabriele , Gentilini Cacciola Elio , Santinelli Letizia , De Girolamo Gabriella , Spagnolello Ornella , Russo Alessandro , Tarsitani Lorenzo , Ciccozzi Massimo , Mastroianni Claudio M. , d'Ettorre Gabriella , Ceccarelli Giancarlo 
Published: October 2021

AbstractDespite the SARS‐CoV‐2 pandemic not yet being under control, post‐Covid‐19 syndrome is already a challenging topic: long‐term multiorgan sequelae, although increasingly described, have not yet been systematized. As post‐Covid‐19 syndrome can significantly impact both the working capacity and the relationship life of surviving patients, we performed a systematic review of the evidence published over the last year and currently available in medical literature search databases (MEDLINE/Pubmed) and searching clinical trial registries, to evaluate the available evidence among workers. From 31 publications that initially matched inclusion criteria, 13 studies have been considered suitable for relevance and age of subjects. A wide range of patients (16%–87%) have post‐Covid syndrome; pneumological and neuropsychological symptoms were the most common disorders reported. The most frequent organic sequel found in post‐Covid patients was pulmonary fibrosis. The number of symptoms during acute SARS‐CoV‐2 infection, severity of the disease, and high serum levels of d‐dimer were related to high risk of post‐Covid syndrome. In conclusion, post‐Covid‐19 syndrome can significantly impact the health conditions of surviving patients. Rehabilitation and follow‐up in multidisciplinary rehabilitation programs should be considered for working‐age patients.
Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy
Authors: Della Sala Francesca , Fabozzi Antonio , di Gennaro Mario , Nuzzo Stefano , Makvandi Pooyan , Solimando Nicola , Pagliuca Maurizio , Borzacchiello Assunta 
Published: October 2021

AbstractCancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)‐based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic‐ and inorganic‐based NPs, is highlighted. Subsequently, HA‐based nanostructures and their applications in cancer therapy are presented.