bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender representation in food and beverage print ads found in corner stores around schools in Peru and Guatemala
Authors: Mus Sophia , Rozas Lucila , Barnoya Joaquin , Busse Peter 
Published: July 2021

Abstract
ObjectiveThe objective of this study is to assess gender representation in food and beverage print advertisements.ResultsThe study follows a quantitative descriptive approach. Using a content analysis technique, we assessed the gender representation in 200 food and beverage print advertisements found in corner stores located in four areas around schools in Lima, Peru, and Guatemala City, Guatemala (100 advertisements per country). A total of 36% of the ads exhibited a male main character for the case of Guatemala, while in Peru 14% of the ads presented a male main character. Furthermore, in Guatemala, 22% of the main characters were male animated characters. Moreover, 27% of the ads in Guatemala and 17%, in Peru were visually male-oriented. Overall, male characters appeared alongside sports references and in varied settings, whereas female characters were usually holding or consuming the product. In conclusion, although the majority of variables used to assess the representation of gender in food and beverage print advertisements were gender-neutral, those showing gender representation were mostly male-oriented. Despite its limited findings, the study provides evidence for the formulation of public policies and educational content aimed to protect children’s and adolescents’ health from the effects of food marketing.
Ancient Basketry on the Inside: X-ray Computed Tomography for the Non-destructive Assessment of Small Archaeological Monocotyledonous Fragments. Examples from South-east Europe
Authors: Andonova Mila 
Published: July 2021

Abstract
This study proposes non-destructive assessment instrumentation, being the X-ray CT scanning, for the evaluation of archaeological basketry remains prior to any destructive analysis. There are three case studies, originating from two archaeological sites in South-east Europe, with three different stages of preservation (poor, sufficient and very good). In addition, there are two preservation modes – charring and desiccation – along with two conservation situations: treated and untreated with conservation agent fragments. The three different scenarios were chosen to explore the potential range of CT scanning technology when applied to monocotyledonous small-sized archaeological remains. It was proved that this non-invasive X-ray method is particularly suitable in the case of the often-disadvantaged ancient basketry remains.
Epilepsy stigma among medical students of university of Khartoum
Authors: Taha Baraa Adel Osman , Ahmed Khabab Abbasher Hussien Mohamed , Omer Mohammed Eltahier Abdalla , Elmahi Osman Kamal Osman 
Published: July 2021

Abstract
Background

Epilepsy is defined as having two or more unprovoked seizures, which result from excessive neuronal firing in the brain leading to sudden abnormal movements of the body. Epilepsy, which was known previously as the sacred disease, is still accompanied with stigma, myths, misconceptions that renewed with each age. Our main aim is to Assess epilepsy stigma among medical students, university of Khartoum.
Methodology :

A descriptive cross-sectional study was conducted on 331 medical students in University of Khartoum, between January to April 2021. Socio-demographic data of patients were recorded. Knowledge, behavior and reaction of participants towards patients during seizures were assessed.
Results

94% of participants heard about epilepsy. Only 24 respondents weren't familiar with epilepsy. Clinical students’ knowledge was deeper than preclinical students. Belief in supernatural forces as a cause of epilepsy, magic spells and invasion by demons showed no statistically significant difference between clinical and preclinical students. Clinical students’ behavior towards handling seizures correctly more than preclinical students. The majority of responses according relationships with people with epilepsy were positive.
Conclusion & Recommendations :

Medical students of University of Khartoum have good knowledge about epilepsy, as well as good attitude, behavior and relationships with people with epilepsy. More research is obviously required to better understand the roots of epilepsy stigma. Also more studies are needed to show stigma from patient perspective.
CEND1 and GJB6 co-expression as a prognostic factor in colorectal cancer
Authors: Chen Rui , Wang Zhan , Ma Dong , Han Yijiang , Liu Junsong , Che Xiangming 
Published: July 2021

Abstract
Background: Perineural invasion is an important mechanism of cancer progression that is not well understood at present. The present study explored the relationship between GJB6, CEND1, and cell-cell communication as regulators of colorectal cancer patient survival and clinicopathological findings.Method: Immunohistochemical staining was performed to assess CEND1 and GJB6 expression levels in CRC patient samples, while survival outcomes were assessed using Kaplan-Meier curves and log-rank tests.Results: Elevated CEND1 expression was associated with tumor location, poor differentiation, and perineural invasion, while GJB6 expression was positively correlated with TNM stage, distant metastasis, and perineural invasion. In addition, GJB6 and CEND1 protein levels were correlated with one another in CRC patient tissues, and high expression of both of these proteins was associated with a higher risk of perineural invasion. CEND1+/GJB6+ status was also associated with poorer patient survival, highlighting both of these proteins as prognostic biomarkers in CRC patients.Conclusion: Elevated levels of CEND1 and GJB6 are independent predictors of poorer CRC patient prognosis.
Anisotropic optical response of gold-silver alloys
Authors: Carvalho Hiago Maurilio Lopes , Dias Mariama Rebello Sousa , Bezerra Anibal Thiago 
Published: July 2021

Abstract
Gold and silver alloys enable novel opportunities for engineering materials with distinct optical responses. Here we investigate the optical properties of gold and silver (Ag x Au 1−x) structures using First-Principle Density Functional Theory (DFT) for gold concentrations varying from 0% up to 100% with steps of 25%. Results of the optical permittivity are analyzed with the independent particle approximation and compared with previously reported theoretical and experimental works. The pure systems and the ones with unbalanced concentrations exhibit isotropic optical responses. The Ag 0.50 Au 0.50 shows an anisotropic response among the y-direction and the xz-direction, mainly in the intraband transition energy range. The anisotropy is elucidated in terms of the d-orbitals density of states and the charge distribution with the structure. The anisotropic optical response can be the origin of the discrepancies among reported experimental results for structures with the same stoichiometry.
Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by regulating miR-34a-3p/BIRC5 to inhibit hypoxia-induced apoptosis of bone-marrow mesenchymal stem cells
Authors: Zhang Fei , Peng Wuxun , Wang Tao , Zhang Jian , Dong Wentao , Wang Chuan , Xie Zhihong , Yan Yanglin 
Published: July 2021

Abstract
Bone-marrow mesenchymal stem cells (BMSCs) have been used in the treatment of early steroid-induced osteonecrosis of the femoral head (SONFH). However, the hypoxic microenvironment in the osteonecrotic area leads to hypoxia-induced apoptosis of transplanted BMSCs, which limits their efficacy. Therefore, approaches that inhibit hypoxia-induced apoptosis of BMSCs are promising for augmenting the efficacy of BMSC transplantations. Our present study found that under hypoxia, expression of the long non-coding RNA (Lnc), transmembrane protein 235 (Tmem235), was down-regulated, expression of Bcl-2-associated X protein was up-regulated, expression of B-cell lymphoma-2 protein was down-regulated, and the apoptotic rate of BMSCs was over 70%. However, overexpression of Lnc Tmem235 reversed hypoxia-induced apoptosis of BMSCs and promoted their survival. These results demonstrated that Lnc Tmem235 effectively inhibited hypoxia-induced apoptosis of BMSCs. Mechanistically, we found that Lnc Tmem235 exhibited competitive binding to miR-34a-3p with BIRC5 mRNA, which is an inhibitor of apoptosis; this competitive binding relieved the silencing effect of miR-34a-3p on BIRC5 mRNA to ultimately inhibit hypoxia-induced apoptosis of BMSCs by promoting the expression of BIRC5. Furthermore, we co-cultured BMSCs overexpressing Lnc Tmem235 with xenogeneic antigen-extracted cancellous bone to construct tissue-engineered bone to repair a model of early SONFH in vitro. The results showed that overexpression of Lnc Tmem235 effectively reduced apoptosis of BMSCs in the hypoxic microenvironment of osteonecrosis and improved the effect of BMSC transplantation. Taken together, our findings elucidate that Lnc Tmem235 inhibited hypoxia-induced apoptosis of BMSCs by regulating the miR-34a-3p/BIRC5 axis, thus improving the transplantation efficacy of BMSCs for treating early SONFH.
NanoKremny effect on the quality of grapes and wines
Authors: Aleinikova Natalia , Peskova Irina , Ostroukhova Elena , Galkina Yevgenia , Didenko Pavel , Probeigolova Polina , Lutkova Nataliya 
Published: July 2021

Introduction. There is still an urgent need in viticulture for studying the effect of tank mixtures of pesticides and bioactive substances on Vitis vinifera and, therefore, the quality and composition of wine. We aimed to study the effect of NanoKremny (silicon fertilizer) treatment of the grapevine on the productivity and quality of grape harvest, as well as the quality of dry wines.
Study objects and methods. Grape varieties from three vineyards in Crimea and the wines produced from them. We applied standard methods used in viticulture, plant protection, and oenological practice. Organic acids and volatile components in grapes and wines were determined by high-performance liquid chromatography and gas chromatography.
Results and discussion. We found that the most effective use of NanoKremny was threefold at 0.15 L/ha during the periods of active growth and formation of vegetative and generative organs in grapevines. It had a positive effect on vegetative development, water balance, productivity of grape plants, as well as yield quality and quantity. Also, NanoKremny decreased the development of mildew and oidium diseases, preserved the content of titratable acids in grapes during their ripening, as well as accumulated phenolic compounds, tartaric and malic acids in grape berries.
Conclusion. We found no negative effect of NanoKremny treatment of the grapevine on the physicochemical parameters and sensory characteristics of wines. Thus, this preparation can be used as a bioorganic additive in viticulture.
Results of surgical treatment of localized and locally advanced adrenocortical cancer in children
Authors: Temniy A. S. , Kazantsev A. P. , Kerimov P. A. , Kalinchenko N. Yu. , Rubanskaya M. V. , Sardalova S. A. , Varfolomeeva S. R. 
Published: July 2021

Introduction. Adrenal cortical carcinoma (ACC) is a rare cancer but is the most common primary cancer in the adrenal gland. Despite the low incidence of ACC the mortality rate ranges from 0.04 to 0.2 %, in the overall structure of cancer mortality. Treatment of ACC is mainly surgical and radical surgical excision is the treatment of choice for local disease stages.Aim of the study — to present our results of surgical treatment of localized and locally advanced ACC in children and to determine the risk factors of relapse.Materials and methods. Twenty-eight patients (median age of 47.8 (06—216) mo.) with localized and locally advanced ACC underwent a retrospectively analysis. Stage I, II, and III revealed in 12 (45 %), 7 (25 %), and 9 (30 %), respectively. In 19 (68 %) cases the secretion of one or more hormone observed. Macroscopically and microscopically complete resection were performed in 26 (93 %) and 23 (82 %) patients, respectively. The median tumor volume was 183 (3.6—1608) cm3 and the median tumor weight was 207.9 (48—710) g.Results. Five-year overall (OS) and relapse-free (RFS) survival were 71 % and 69 %, respectively. OS and RFS according to stage I, II, and III were 100 % vs. 71 % vs. 17 % and 100 % vs. 71 % vs. 14 % respectively. The radical surgical resection and the level of Ki-67 expression influenced significantly the rates of OS and RFS (p < 0.001).Conclusion. The main factor affecting the survival rate of ACC in children with stages I—III is the radical surgical resection. It should be taken into account when planning postoperative therapy. Some of biological characteristics of the tumor could also significantly affect the results of treatment.
Extended surgical interventions in children with retinoblastoma invasion into the optic nerve
Authors: Ushakova T. L. , Tuzova E. A. , Shutova A. D. , Gorovtsova O. V. , Gasparyan T. G. , Bekyashev A. Kh. , Polyakov V. G. 
Published: July 2021

Introduction. Standard eye enucleation (EE) may not always guarantee a sufficient length of resection of the optic nerve (ON) so that the tumor cells do not spread along the optic nerve at the intersection line. Surgical access and the scope of surgical intervention are determined by the spread and localization of the tumor, as well as the qualification of the operating team.Purpose— to evaluate the role of extended surgical interventions in the spread of extraocular tumors on the ON.Materials and methods. The study included 9 patients with retinoblastoma (RB) and macroinvasion of the ON during primary magnetic resonance imaging (MRI) and/or micromorphological invasion of the ON resection line after EE. 4 of the 9 patients were treated with primary/secondary EE, induction chemotherapy (CT) and high-dose CT (HDCT), radiation therapy (RT). 5 out of 9 patients underwent secondary extended surgical interventions: exenteration of the orbit (n = 1), osteoplastic lateral orbitotomy with precanal resection of the ON (n = 2) in combination with EE in one case, subfrontal craniotomy (n = 1) and orbitozygomatic craniotomy (n = 1) with prechiasmal resection of the ON and EE with adjuvant RT (excluding the latter case) and CT, without HDCT.Results. It should be noted that the overall survival (OS) of 5 patients with complete microscopic resection (R0) after extended secondary operations was 75 ± 0.217 % with an average follow-up period of 77.25 ± 18.8 months, while in 4 patients with R1 (n = 4) without secondary extended operations with HDCT reached only 50 ± 0.25 % with an average follow-up period of 57 ± 24.8 months.Conclusion. MRI is mandatory for the primary diagnosis of RB, especially when there is a risk of the tumor spreading through the ON. Secondary surgery with R0-resection has a positive effect on survival. The need for adjuvant RT and CT after surgery should be discussed.
Effects of Patient Portal Use on Patient Satisfaction: Survey and Partial Least Squares Analysis
Authors: Kinney Aaron P , Sankaranarayanan Balaji 
Published: July 2021

Background
With digital delivery of health care services gaining prominence, patient portals have become a mainstay of many health care organizations. Despite the importance of patient portals, inconclusive data exist regarding the effect of patient portal use on patient satisfaction.

Objective
The aim of this study is to understand the relationship between the postadoptive use of patient portals and patient satisfaction outcomes.

Methods
Postadoptive use of patient portals has a positive relationship with the 3 dimensions of patient satisfaction, mediated by gratification, health self-awareness, and health perceptions. A total of 504 valid patient portal user responses were collected, and partial least squares analysis was performed to analyze the data.

Results
Patient satisfaction was captured using three dimensions: care team interaction, atmosphere, and instruction effectiveness. The results show that postadoptive use of patient portals has a positive influence on all 3 dimensions of patient satisfaction through the mediating variables of gratification, health self-awareness, and health perceptions. Specifically, postadoptive use had significant positive influence on gratification, health self-awareness, and health perceptions. Each of the 3 patient perceptions had significant positive influence on all 3 dimensions of patient satisfaction: care team interaction, atmosphere, and instruction effectiveness. Specifically, our model explained 31.8% of the care team interaction, 40.6% of the atmosphere, and 39.1% of the instruction effectiveness.

Conclusions
Our model shows that patient portal use can influence patient satisfaction through the mediating effects of gratification, health self-awareness, and health perception. Patient satisfaction is an important outcome for health care organizations. Therefore, by promoting effective patient portal use and fostering patient perceptions, health care organizations can improve patient satisfaction.
The Effectiveness of a Web-Based Self-Help Program to Reduce Alcohol Use Among Adults With Drinking Patterns Considered Harmful, Hazardous, or Suggestive of Dependence in Four Low- and Middle-Income Countries: Randomized Controlled Trial
Authors: Schaub Michael P , Tiburcio Marcela , Martínez-Vélez Nora , Ambekar Atul , Bhad Roshan , Wenger Andreas , Baumgartner Christian , Padruchny Dzianis , Osipchik Sergey , Poznyak Vladimir , Rekve Dag , Landi Moraes Fabricio , Monezi Andrade André Luiz , Oliveira Souza-Formigoni Maria Lucia ,   WHO E-Health Project On Alcohol And Health Investigators Group
Published: July 2021

Background
Given the scarcity of alcohol prevention and use disorder treatments in many low- and middle-income countries (LMICs), the World Health Organization has launched an eHealth portal that includes the web-based self-help program “Alcohol e-Health.”

Objective
We aimed to test the effectiveness of the Alcohol e-Health program in a randomized controlled trial.

Methods
This was a two-arm, individually randomized, and controlled trial across four LMICs comparing the self-help program and a psychoeducation and internet access as usual waiting list. Participants were broadly recruited from community samples in Belarus, Brazil, India, and Mexico from January 2016 through January 2019. The primary outcome measure was change in the Alcohol Use Disorders Identification Test (AUDIT) score with a time frame of 6 months between baseline and follow-up. Secondary outcomes included self-reported numbers of standard drinks over the previous week and cessation of harmful or hazardous drinking (AUDIT score <8).

Results
For this study, we recruited 1400 predominantly male (n=982, 70.1%) at least harmful or hazardous alcohol drinkers. The mean age was 37.6 years (SD 10.5). The participants were recruited from Brazil (n=587), Mexico (n=509), India (n=212), and Belarus (n=92). Overall, complete case analysis identified higher AUDIT changes in the intervention group (B=−4.18, 95% CI −5.42 to −2.93, P<.001, d=0.56) that were mirrored by changes in weekly standard drinks (B=−9.34, 95% CI −15.90 to −2.77, P=.005, d=0.28) and cessation rates for harmful or hazardous drinking (χ21=14.56, N=561, P<.001). The supplementary intention-to-treat analyses largely confirmed these initial results.

Conclusions
The expansion of the Alcohol e-Health program to other LMICs with underdeveloped alcohol prevention and treatment systems for alcohol use disorders should be considered after successful replication of the present results.

Trial Registration
ISRCTN ISRCTN14037475; https://www.isrctn.com/ISRCTN14037475

International Registered Report Identifier (IRRID)
RR2-10.1111/add.14034
Digital Medical Device Companion (MyIUS) for New Users of Intrauterine Systems: App Development Study
Authors: Karakoyun Toeresin , Podhaisky Hans-Peter , Frenz Ann-Kathrin , Schuhmann-Giampieri Gabriele , Ushikusa Thais , Schröder Daniel , Zvolanek Michal , Lopes Da Silva Filho Agnaldo 
Published: July 2021

Background
Women choosing a levonorgestrel-releasing intrauterine system may experience changes in their menstrual bleeding pattern during the first months following placement.

Objective
Although health care professionals (HCPs) can provide counseling, no method of providing individualized information on the expected bleeding pattern or continued support is currently available for women experiencing postplacement bleeding changes. We aim to develop a mobile phone–based medical app (MyIUS) to meet this need and provide a digital companion to women after the placement of the intrauterine system.

Methods
The MyIUS app is classified as a medical device and uses an artificial intelligence–based bleeding pattern prediction algorithm to estimate a woman’s future bleeding pattern in terms of intensity and regularity. We developed the app with the help of a multidisciplinary team by using a robust and high-quality design process in the context of a constantly evolving regulatory landscape. The development framework consisted of a phased approach including ideation, feasibility and concept finalization, product development, and product deployment or localization stages.

Results
The MyIUS app was considered useful by HCPs and easy to use by women who were consulted during the development process. Following the launch of the sustainable app in selected pilot countries, performance metrics will be gathered to facilitate further technical and feature updates and enhancements. A real-world performance study will also be conducted to allow us to upgrade the app in accordance with the new European Commission Medical Device legislation and to validate the bleeding pattern prediction algorithm in a real-world setting.

Conclusions
By providing a meaningful estimation of bleeding patterns and allowing an individualized approach to counseling and discussions about contraceptive method choice, the MyIUS app offers a useful tool that may benefit both women and HCPs. Further work is needed to validate the performance of the prediction algorithm and MyIUS app in a real-world setting.
Impact of the COVID-19 Pandemic on the Mental Health of College Students in India: Cross-sectional Web-Based Study
Authors: Chaudhary Amar Prashad , Sonar Narayan Sah , TR Jamuna , Banerjee Moumita , Yadav Shailesh 
Published: July 2021

Background
The COVID-19 pandemic has created a mental health crisis among college students in India due to lockdown restrictions, overwhelming numbers of COVID-19 cases, financial difficulty, etc. This mental health crisis has led to high degrees of fear, anxiety, and depression among college students.

Objective
The aim of this study is to investigate symptoms of fear, depression, and anxiety due to the COVID-19 pandemic among college students in India.

Methods
This cross-sectional web-based study was conducted using a Google Forms questionnaire. The Google Form included a sociodemographic questionnaire and psychometric scales evaluating the psychological and behavioral impacts of the COVID-19 pandemic. Thus, both qualitative and quantitative analyses were performed in the study.

Results
A total of 324 college students participated in this study, of whom 180 (55.6%) were male and 144 (44.4%) were female. After assessment of the psychometric scales, it was found that of the 324 students, 223 (68.8%) had high fear of COVID-19, 93 (28.7%) had moderate to severe depression, and 167 (51.5%) had mild to severe anxiety. Among the identified risk factors, having a family member who was infected with COVID-19 was significantly associated with anxiety and depression, with P values of .02 and .001, respectively. In addition, the correlations of the Fear of COVID-19 Scale with the Generalized Anxiety Disorder-7 scale and the Patient Health Questionnaire-9 were found to be 0.492 and 0.474, respectively.

Conclusions
This research concludes that there is a very high fear of COVID-19 among students, along with anxiety and depression symptoms. This study also concludes that the Fear of COVID-19 Scale has a moderate positive correlation with the anxiety and depression scales, respectively.