bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Risk of Ovarian Cancer Associated With rs9898876 Sex Hormone-binding Globulin Gene Variant
Authors: Zidi Sabrina , Stayoussef Mouna , Sontini Feryel K , Mezlini Amel , Yacoubi-Loueslati Besma , Almawi Wassim Y 
Published: November 2021

Abstract
Background. Ovarian cancer (OC) is one of the most common gynecologic cancers,with significant morbidity and mortality. The risk of OCis influenced by hormone status, of which sex hormone-binding globulin (SHBG), whichinfluences the serum availability of steroid sex hormones, is implicated in the pathogenesis and evolution of OC. The aim of this study is to evaluate the involvement of common SHBG gene variants in OC susceptibility and evolution. Materials. A case control study including 71 OC patients and 74 cancer-free controls, who were genotyped for rs9898876, rs13894, rs1799941 and rs6257 SHBG SNP. Genotyping was done by the allelic discrimination method, using VIC- and FAM-labeled primers.Results. The minor allele frequencies of rs9898876, rs13894, rs1799941 and rs6257 SHBG SNP was comparable between OC cases and control women, implying no significant associations of the tested variants and overall OC risk. Taking homozygous wild-type genotype as reference (OR=1.00), heterozygous rs9898876 (G/T), and minor allele-carrying genotypes [G/T+T/T] were associated with reduced risk of OC. Whilers9898876 heterozygosity (G/T) was predictive of OC occurrence, no significant association of the remaining three tested SNPs was noted with altered risk of OC. Irrespective of FIGO staging, the four tested SHBG SNPs were not associated with the clinical progression of OC.Conclusion. In conclusion, SHBG rs9898876 is associated with a decreased risk of OC, and thus constitutes a potential diagnostic biomarker of OC.
Association Between Social Media Use and the Acceptance of Covid-19 Vaccination Among the General Population in Saudi Arabia – A Cross-sectional Study
Authors: Othman Sahar S. , Alsuwaidi Abeer , Aseel Rafal , Alotaibi Reema , Bablgoom Reem , Alsulami Ghadeer , Alharbi Razan , Ghamri Ranya 
Published: November 2021

Abstract
BackgroundThe 2019 Coronavirus Disease Pandemic (COVID-19) is a worldwide global epidemic. Although acceptance of COVID-19 vaccination will be a critical step in combating the pandemic, achieving high uptake will be difficult, and potentially made more difficult by social media misinformation. This study aimed to examine the association between social media use and acceptance of receiving COVID-19 vaccine among the general population in Saudi Arabia.MethodologyA cross-sectional study was conducted from June 17 to June 19, 2021 among 504 participants of the general population in Saudi Arabia. The data were collected using a three-part online questionnaire (sociodemographic characteristics, medical and vaccination history, pattern of social media use). ResultsAmong 504 participants who completed the survey, 477 participants were acceptant of the vaccine and 27 were non-accepting. A total of 335 individuals had already received the vaccine, 142 were willing to receive the vaccine and 27 were unwilling. One hundred and thirty participants denied using social media for COVID-19 news. Four factors were found to be significant in influencing vaccine acceptance in univariate analysis: having a chronic condition, believing that infertility is a side effect of the COVID-19 vaccine, being concerned about a serious side effect from the vaccine and basing the decision to be vaccinated on social media information. Two of these factors fell away on multivariate analysis: basing the decision on social media information and a belief that vaccination causes infertility, suggesting that the associations are dependent on other factors.Conclusion‏In conclusion, there was no significant independent relationship between social media usage and people's willingness to receive a COVID-19 vaccination.
Tracking of Anthropometric Characteristics From Childhood To Adolescence: An 8-Year Follow-Up Findings From The Czech ELSPAC Study
Authors: Zvonar Martin , Štefan Lovro , Kasović Mario , Piler Pavel 
Published: November 2021

Abstract
Background
Although evidence suggests that obesity track well from childhood to adolescence, most of the research has been done in Western and high-income countries. Moreover, most of the studies have tracked body-mass index, as a proxy of nutritional status, while tracking characteristics of circumferences and skinfold thicknesses have been less studies. Therefore, the main purpose of the study was to explore tracking characteristics of complete anthropometric data from childhood to adolescence.
Methods
This sub-study was part of the Czech ELSPAC study. In the present 8-year longitudinal study, we collected information from pediatrician’s medical records at the ages of 8 y (n=888), 11 y (n=1065), 13 y (n=811) and 15 y (n=974), including circumferences (head, chest, waist, hips, and arm), indices (body-mass index, waist-to-hip ratio and waist-to-height ratio) and skinfold thicknesses (biceps, triceps, subscapula, suprailiaca, thigh and the sum of 5 skinfolds). Participants were recruited from the two selected regions of the Czech Republic (Brno and Znojmo). Linear generalized estimating equations were conducted to analyze tracking patterns over an 8-year follow-up period for all anthropometric measurements.
Results
Tracking coefficients were moderate to strong, ranging from 0.40 to 0.62 for circumferences, 0.41 to 0.74 for indices and 0.72 to 0.86 for skinfolds. For body-mass index and waist circumference children who were overweight/obese at the age of 8 y were 11.31 (95% CI=8.41 to 15.22, p<0.001) and 10.73 (95% CI=7.93 to 14.52, p<0.001) more likely to be overweight/obese and to have abdominal obesity at the age of 15 y.
Conclusions
Findings show moderate to strong tracking of anthropometric characteristics, i.e. circumferences track moderately well, while strong tracking for indices and skinfold thicknesses is observed. Moreover, strong tracking of general overweight/obesity and abdominal obesity between ages 8 y and 15 y indicates that the detection of these risk factors at the beginning of primary school should be advocated.
An Environmental Information System for the Exploration of Energy Systems
Authors: Rink Karsten , Şen Özgür Ozan , Schwanebeck Malte , Hartmann Tim , Gasanzade Firdovsi , Nordbeck Johannes , Bauer Sebastian , Kolditz Olaf 
Published: November 2021

Abstract
The transition to renewable energy sources requires extensive changes to the energy system infrastructure ranging from individual households to the national scale. During this transition, stakeholders must be able to make informed decisions, researchers need to investigate possible options and analyse scenarios and the public should be informed about developments and options for future infrastructure. The data and parameters required for this are manifold and it is often difficult to create an overview of the current situation for a region of interest. We propose an environmental information system for the visualisation and exploration of large collections of heterogeneous data in the scope of energy system infrastructure and subsurface geological energy storage technologies. Based on the study area of Schleswig-Holstein, a federal state in Germany, we have set up a virtual geographic environment integrating GIS data, topographical models, subsurface information, and simulation results. The resulting application allows users to explore data collection within a unified context in 3D space, interact with datasets, and watch animation of selected simulation scenarios to gain a better understanding of the complex interactions of processes and datasets. Based on the cross-platform game engine Unity, our framework can be used on regular PCs, head-mounted displays, and virtual reality environments and can support domain scientists during assessment and exploration of the data, encourages discussions and is an effective means for outreach activities and presentations for stakeholders or the interested public.
Diagnosis of Key Ecological Problems and Layout of Ecological Restoration Projects- A Case Study of the Aksu River Basin, China
Authors: Xie Ling , Wang Hongwei , Liu Suhong , Li Yudong 
Published: November 2021

Abstract
The sustainable development of ecological environments is the basis of the sustainable development of inland river basins in arid areas with fragile ecological environments. The aim of our study is to diagnose the ecological problems of the Aksu River basin (ARB) and explore the ecological security pattern (ESP) and the layout and implementation path of ecological protection projects for mountains, rivers, forests, farmland, lakes, grasslands and deserts (MRFFLGD) in arid areas under different security levels. The Aksu River, the largest source of the Tarim River, was selected as the case study. The equivalent factor evaluation method (EFEM) was used to estimate the ecological service value (ESV), and the InVEST model was employed to quantify the ecological function indicators. By constructing the richness index, the ESV of the study area was measured spatially, and the ecological problems in the ARB were identified and diagnosed. Using cold/hot spot detection analysis and the minimum cumulative resistance (MCR) model, the ESPs at three security levels were constructed. The layout of ecological protection measures and the implementation path for MRFFLGD were studied. The results showed that the ESV of ARB showed an upwards trend from 1990 to 2018, and the three services of water conservation, waste treatment and soil formation and retention grew fastest. The value of ecosystem services in the study area in 2018 ranged from 5,390 yuan to 131,080 yuan/hm2. The high-value areas were mainly located in the oasis and the northern mountainous area, and the low-value areas were mainly located in the desert area. The ecological source areas of high, medium and low safety levels were 1806.3 km2, 3416.8 km2 and 4804.32 km2, respectively. Based on the spatial distribution of ESV in the ARB and the preliminary diagnosis of the basic ecological problems in the study area, three kinds of ecological protection engineering models, namely, conservation, natural restoration and assisted regeneration, were proposed for the four types of ecological protection zones. To provide a decision-making basis for ecological environmental management and regional sustainable development in the ARB, the optimization patterns of points (6 key ecological protection projects), lines (ecological corridors) and polygons (ecological source areas) were constructed. The results of this study can also serve as a reference for ecological environmental protection in other arid inland river basins.
Concordance of Self- and Informant-Rated Depressive Symptoms in Nursing Home Residents with Dementia: Cross-Sectional Findings
Authors: O'Sullivan Julie Lorraine , Schweighart Roxana , Lech Sonia , Kessler Eva-Marie , Tegeler-Nonnen Christina , Teti Andrea , Nordheim Johanna , Gellert Paul 
Published: November 2021

Abstract
Background: Depression is highly prevalent in nursing home residents living with moderate to severe dementia. However, assessing depressive symptoms in residents with dementia can be challenging and may vary by rater perspective. We aimed to investigate the concordance of, and factors associated with self- and informant-rated depressive symptoms in nursing home residents with dementia.Methods: Cross-sectional data was collected from N=162 nursing home residents with dementia (age: 53-100; 74% women). Self-ratings were assessed with the Geriatric Depression Scale, while the Subscale D of the Neuropsychiatric Inventory was used for informant-ratings. Cohen’s Kappa was calculated to determine concordance of both measures and of each with antidepressant medication. Associations with sociodemographic variables, self- and informant-rated quality of life, dementia stage, neuropsychiatric symptoms, functional status and antidepressant medication were analysed with multivariate linear mixed models.Results: Concordance between self- and informant-rated depressive symptoms was minimal (Cohen’s Kappa=.22, p=.02). Self-reported depression was negatively associated with self-rated quality of life (β=-.37; 95%CI: -.48 to .26, p<.001), informant-rated quality of life (β=-.31; 95%CI: -51 to .10, p=.003) and functional status (β=-.15; 95%CI: -.27 to .03, p=.02), whilst informant-rated depression revealed negative associations with informant-rated quality of life (β=-.32; 95%CI: -.54 to .11, p=.003) and dementia stage (β=-.27; 95%CI: -.50 to .03, p=.028). No concordance was found with antidepressant medication.Conclusions: In line with our expectations, low agreement and unique association patterns were found for both measures. These findings indicate that both instruments address different aspects of depression und underline the need for comprehensive approaches when it comes to detecting signs of clinically relevant depressive symptoms in dementia. Trial registration: The trial was registered with the ISRCTN registry (Trial registration number: ISRCTN98947160)
Applicability of Reddish Orange Light Emitting Samarium (III) Complexes For Biomedical and Multifunctional Optoelectronic Devices
Authors: Hooda Pooja , Taxak V. B. , Malik R. K. , Khatri Savita , Kumari Poonam , Khatkar S. P. , Kumar Rajesh 
Published: November 2021

Abstract
Six crimson samarium (III) complexes based on β-ketone carboxylic acid and ancillary ligands were synthesized by adopting grinding technique. All synthesized complexes were investigated via employing elemental analysis, infrared, UV-Vis, NMR, TG/DTG and photoluminescence studies. Optical properties of these photostimulated samarium (III) complexes exhibit reddish-orange luminescence due to 4G5/2→6H7/2 transition at 606 nm of samarium (III) ions. Further, energy band gap, color purity, CIE color coordinates, CCT and quantum yield of all complexes were determined accurately. Replacement of water molecules by ancillary ligands enriched the complexes (S2-S6) with decay time, quantum yield, luminescence, energy band gap and biological properties than parent complex (S1). Interestingly, these efficient properties of complexes may find their applications in optoelectronic and lighting systems. In addition to these the antioxidant and antimicrobial assays were also investigated to explore the application in biological assays.
Evolution of Warm Season Intense Rainfall in Yaan Against a Cold-Anomaly Background
Authors: Hu Xuelin , Yuan Weihua , Yu Rucong 
Published: November 2021

Abstract
This study investigates the rainfall characteristics during intense rainfall over Yaan against a cold-anomaly background, aiming to refine the understanding of different kinds of rainfall events across complex terrain. Hourly rain gauge records, ERA5 reanalysis data and the black body temperature of cloud tops derived from FY-2E were used. The results show that against a cold-anomaly background, the regional rainfall events (RREs) in Yaan exhibit west-to-east propagation, which is different from the north-to-south evolution of warm RREs. The middle and upper troposphere is dominated by a negative geopotential height anomaly corresponding to the cold anomaly. The cyclonic circulation at the higher level associated with the negative geopotential height anomaly bends the high-level jet to the south, forming a divergent zone over the Tibetan Plateau (TP) and guiding mid-level systems to move eastward. The cyclonic circulation at the mid-level produces a wind shear zone over the TP, generating anomalous vorticity that continuously moves eastward and develops to influence the rainfall over Yaan. The cold Yaan RREs are closely related to the TP low-pressure systems (both vortex and shearline). The anomalous vorticity over the TP can influence the local vortex over the eastern periphery of the TP at a distance mainly by the horizontal advection of anomalous vorticity by the mean flow and then enhance the local vortex mainly by anomalous convergence when it moves near Yaan.
Liver-specific LINC01146, a Promising Prognostic Indicator, Inhibits Malignant Phenotype of Hepatocellular Carcinoma Cells Both in Vitro and in Vivo
Authors: Ma Xiaoyun , Mo Meile , Tan Chao , Tan Jennifer Hui Juan , Huang Huishen , Liu Bihu , Huang Dongping , Liu Shun , Zeng Xiaoyun , Qiu Xiaoqiang 
Published: November 2021

Abstract
BackgroundLong non-coding RNAs (lncRNAs) have been proven to be involved in the development of hepatocellular carcinoma (HCC). We aimed to investigate the function of LINC01146 in HCC.MethodsThe expression of LINC01146 in HCC tissues was explored via the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and was verified using quantitative real-time polymerase chain reaction (qRT-PCR) in our HCC cohort. Kaplan-Meier analysis was used to assess the relationship between LINC01146 and the prognosis of HCC patients. Cell Counting Kit 8, colony formation assays, transwell assays, flow cytometric assays, and tumor formation models in nude mice were conducted to reveal the effects of LINC01146 on HCC cells both in vitro and in vivo. Bioinformatic methods were used to explore the possible potential pathways of LINC01146 in HCC.ResultsLINC01146 was significantly decreased in HCC tissues compared with adjacent normal tissues and it was found to be related to the clinical presentations of malignancy and the poor prognosis of HCC patients. Overexpression of LINC01146 inhibited the proliferation, migration, and invasion, while promoting the apoptosis of HCC cells in vitro. On the contrary, downregulation of LINC01146 exerted the opposite effects on HCC cells in vitro. In addition, overexpression of LINC01146 significantly inhibited tumor growth, while downregulation of LINC01146 promoted tumor growth in vivo. Furthermore, the co-expression genes of LINC01146 were mainly involved in the “metabolic pathway” and “complement and coagulation cascade pathway”. ConclusionLINC01146 expression was found to be decreased in HCC tissues and associated with the prognosis of HCC patients. It may serve as a cancer suppressor and prognostic biomarker in HCC.
Extracellular HSP90α-LRP1 Signaling Promote Pancreatic Cancer Metastasis and Chemoresistance Via Regulating Epithelial-To-Mesenchymal Transition
Authors: Xue Nina , Du Tingting , Lai Fangfang , Jin Jing , Ji Ming , Chen Xiaoguang 
Published: November 2021

Abstract
Extracellular heat shock protein 90α (HSP90α) has been reported to promote cancer cell invasion and migration. However, whether pancreatic cancer (PC) cells expressed membrane-bound or secreted HSP90α and its underlying mechanism for PC progression were still unclear. Our study pointed out that highly invasive Capan2 cells has a higher level of secreted HSP90α, rather than membrane HSP90α, compared with those of less invasive PL45 cells. The conditioned medium of Capan2 cells or recombinant HSP90α protein was able to stimulate the migration and invasion of PL45 or capan2 cells, which could be prevented by a neutralizing anti-HSP90α antibody. Furthermore, secreted HSP90α promoted elements of epithelial-mesenchymal transition (EMT) in PL45 cells, including increases in vimentin and snail expressions, decreases in E-cadherin expression and changes in cell shape towards a mesenchymal phenotype, but these phenomena were reversed by anti-HSP90α antibody in Capan2 cells. In addition, high levels of low-density lipoprotein receptor-related protein 1 (LRP1) mRNA were associated with worsened patient survival in pancreatic adenocarcinoma. LRP1 as a receptor of eHSP90α for its stimulatory role of PC cells EMT and metastasis by activating AKT signaling. Down-regulation of LRP1 could promote chemosensitivity to gemcitabine and doxorubicin, but not to topotecan and paclitaxel in Capan2 cells. Therefore, our study reveals a critical role of secreted HSP90α on EMT events and suggests blocking secreted HSP90α underlies an aspect of metastasis and chemoresistance.
Micro- and Nanometric Characterization of the Celestite Skeleton of Acantharian Species (Radiolaria, Rhizaria)
Authors: Fujimaki Rina , Suzuki Noritoshi , Kimoto Katsunori , Nagai Yukiko , Oaki Yuya , Shimode Shinji , Toyofuku Takashi , Imai Hiroaki 
Published: November 2021

Abstract
We studied the micrometric morphology and nanometric structure of the celestite (SrSO4) skeleton of acantharian family Acanthometridae. A body of the skeleton composed of 20 radial spines with four blades was characterized using microfocus X-ray computed tomography. The regular arrangement of three types of spines was clarified with the connection of the blades around the root of each spine. The surface of the spines was covered with a chitin-based organic membrane to prevent dissolution in sea water. On the nanometric scale, the mesocrystalline structure that consists of nanoscale grains having a distorted single-crystal nature was revealed using scanning and transmission electron microscopy, electron diffraction, and Raman spectroscopy. The acantharian skeletons have a crystallographically controlled architecture that is covered with a protective organic membrane.
HIF-1α Negatively Regulates Irisin Expression Which Involves in Muscle Atrophy Induced by Hypoxia
Authors: Liu Shiqiang , Fu Pengyu , Ning Kaiting , Wang Rui , Yang Baoqiang , Chen Jiahui , Xu Huiyun 
Published: November 2021

Abstract
Background: Exposure to high altitude environment leads to skeletal muscle atrophy. As a hormone secreted by skeletal muscles after exercise, irisin contributes to promoting muscle regeneration and ameliorating skeletal muscle atrophy, but its role in hypoxia-induced skeletal muscle atrophy is still unclear. Methods & Results: Our results showed that 4 w of hypoxia exposure significantly reduced body weight and gastrocnemius muscle mass of mice, as well as grip strength and the duration time of treadmill exercise. Hypoxia treatment increased HIF-1α expression and decreased both the circulation level of irisin and its precursor protein FNDC5 expression in skeletal muscle. In vitro, CoCl2-induced chemical hypoxia and 1% O2 ambient hypoxia both reduced FNDC5, along with the increase of HIF-1α. Moreover, the decline of area and diameter of myotubes caused by hypoxia were rescued by inhibiting HIF-1α via YC-1. and Conclusions: Collectively, our research indicated that FNDC5/irisin was negatively regulated by HIF-1α and could participate in the regulation of muscle atrophy caused by hypoxia.
Fieldable Muon Spectrometer Using Multi-Layer Pressurized Gas Cherenkov Radiators and Its Applications
Authors: Bae Junghyun , Chatzidakis Stylianos 
Published: November 2021

Abstract
Cosmic ray muons have been considered as a non-conventional radiation probe in various applications. To utilize cosmic ray muons in engineering applications, two important quantities, trajectory and momentum, must be known. The muon trajectories are easily reconstructed using two-fold detector arrays with a high spatial resolution. However, precise measurement of muon momentum is difficult to be achieved without deploying large and expensive spectrometers such as solenoid magnets. Here, we propose a new method to estimate muon momentum using multi-layer pressurized gas Cherenkov radiators. This is accurate, portable, compact (< 1m3), and easily coupled with existing muon detectors without the need of bulky magnetic or time-of-flight spectrometers. The results show that not only our new muon spectrometer can measure muon momentum with a resolution of ±0.5 GeV/c in a momentum range of 0.1 to 10.0 GeV/c, but also we can reconstruct cosmic muon spectrum with high accuracy (~90%).