Long-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks
Authors: Suárez-García Inés , Alejos Belén , Moreno Cristina , Martín Torres Juan , Masiá Mar , García-Fraile Lucio J , Riera Melchor , Dalmau David , Rodríguez-Rosado Rafael , Muga Roberto , Moreno Santiago , Jarrín Inma ,   the CoRIS cohort, Moreno Santiago , Jarrín Inma , Dalmau David , Luisa Navarro M , Isabel González M , Garcia Federico , Poveda Eva , Iribarren Jose Antonio , Gutiérrez Félix , Rubio Rafael , Vidal Francesc , Berenguer Juan , González Juan , Ángeles Muñoz-Fernández M , Jarrín Inmaculada , Moreno Cristina , Rava Marta , Izquierdo Rebeca , Marco Cristina , Gómez-García Teresa , Ángeles Muñoz-Fernández M , Juárez Roxana , Portilla Joaquín , Portilla Irene , Merino Esperanza , García Gema , Agea Iván , Sánchez-Payá José , Rodríguez Juan Carlos , Giner Livia , Reus Sergio , Boix Vicente , Torrus Diego , Pérez Verónica , Portilla Julia , Pinargote Héctor , Alemán María Remedios , Lirola Ana López , García Dácil , Díaz-Flores Felicitas , Mar Alonso M , Pelazas Ricardo , Hernández María Inmaculada , Romero Lucia , Bethencourt Abraham , Rodríguez Daniel , Asensi Víctor , Rivas-Carmenado María Eugenia , Magadan Rebeca Cabo , Díaz-Arias Javier , Pulido Federico , Rubio Rafael , Bisbal Otilia , Asunción Hernando M , Rial David , de Lagarde María , Pinto Adriana , Bermejo Laura , Santacreu Mireia , Navarro Roser , Torres Juan Martín , Iribarren José Antonio , José Aramburu M , Camino Xabier , Goenaga Miguel Ángel , Jesús Bustinduy M , Azkune Harkaitz , Ibarguren Maialen , Kortajarena Xabier , Álvarez-Rodriguez Ignacio , Gil Leire , Carmona-Torre Francisco , Carlos Ana Bayona , Sanz Maialen Lekuona , Gutiérrez Félix , Robledano Catalina , Masiá Mar , Padilla Sergio , Adsuar Araceli , Pascual Rafael , Fernández Marta , Galiana Antonio , García José Alberto , Barber Xavier , Abellán Javier García , Telenti Guillermo , Guillén Lucía , Botella Ángela , Mascarell Paula , Carvajal Mar , de la Rica Alba , Ding Carolina , García-Sánchez Lidia , Ena Nuria , López Leandro , Vallejo Jennifer , Gonzalo-Jiménez Nieves , Ruiz Montserrat , Ledesma Christian , López Santiago , Espinosa María , Quiles Ana , Andreo María , Muga Roberto , Sanvisens Arantza , Fuster Daniel , de Quirós Juan Carlos López Bernaldo , Gutiérrez Isabel , Berenguer Juan , Ramírez Margarita , Gijón Paloma , Aldamiz-Echevarría Teresa , Tejerina Francisco , Diez Cristina , Pérez Leire , Fanciulli Chiara , Corral Saray , Peraire Joaquín , Rull Anna , Martí Anna , Viladés Consuelo , Villar Beatriz , Guillem Lluïsa , Olona Montserrat , García-Pardo Graciano , Gómez-Bertomeu Frederic , Alba Verónica , Chafino Silvia , Sánchez Alba , Montero Marta , Tasias María , Calabuig Eva , Salavert Miguel , Fernández Juan , Blanes Rosa , González-García Juan , Delgado-Hierro Ana , Arribas José Ramón , Arribas Víctor , Bernardino José Ignacio , Busca Carmen , Cano-Smith Joanna , Cadiñanos Julen , Castro Juan Miguel , Escosa Luis , Falces Iker , Herranz Pedro , Hontañón Víctor , González-Baeza Alicia , Luz Martín-Carbonero M , Mayoral Mario , Micán Rafael , de Miguel Rosa , Montejano Rocío , Montes Mª Luisa , Ramos-Ruperto Luis , Rodés Berta , Sainz Talía , Sendagorta Elena , Valencia Eulalia , del Mar Arcos M , de Gea Grela Alejandro , López Carlos Oñoro , Blanco José Ramón , Pérez-Martínez Laura , Oteo José Antonio , Ibarra Valvanera , Metola Luis , Sanz Mercedes , Martínez Rosa , Gil Desiré , Cecilio Álvaro , Caballero Ruth , Caudevilla María Aranzazu , Dalmau David , Martinez Marina , Jaén Angels , Cairó Mireia , Martinez-Lacasa Javier , Font Roser , Gisbert Laura , Rivero María , Goikoetxea Maider , Gracia María , Ibero Carlos , Moreno Estela , Repáraz Jesús , Baigorria Fernando , Navarro Gemma , Garcia Manel Cervantes , Isbert Sonia Calzado , Vilasaro Marta Navarro , de los Santos Ignacio , de los Santos Alejandro , García-Fraile Lucio , Martín Enrique , Sánchez-Cerrillo Ildefonso , Calvet Marta , Barrios Ana , Bautista Azucena , Sáez Carmen , Ciudad Marianela , Gutiérrez Ángela , García María Aguilera , Moreno Santiago , del Campo Santos , Casado José Luis , Dronda Fernando , Moreno Ana , Jesús Pérez M , Serrano-Villar Sergio , Vivancos Mª Jesús , Martínez-Sanz Javier , Vallejo Alejandro , Sánchez-Conde Matilde , Pérez-Molina José Antonio , Hermida José Manuel , De La Torre Tarazona Erick , Moreno Elena , Pedraza Laura Martín , García Claudio Díaz , Díaz Jorge , García Alejandro , Ron Raquel , Bernal Enrique , Alcaraz Antonia , Bravo Joaquín , Muñoz Ángeles , Tomás Cristina , Oliver Eva , Selva David , García Eva , González Román , Guijarro Elena , Martínez Rodrigo , Hernández María Dolores , García Federico , Martínez Clara , Medina Leopoldo Muñoz , Álvarez Marta , Chueca Natalia , Vinuesa David , de Salazar Adolfo , Fuentes Ana , Guirao Emilio , Viñuela Laura , Ruiz-Sancho Andrés , Anguita Francisco , Faro Naya , Peregrina José , Chaves Lucia , Illescas Marta , Sánchez Valme , Del Romero Jorge , Raposo Montserrat , Rodríguez Carmen , Puerta Teresa , Carrió Juan Carlos , Vera Mar , Ballesteros Juan , Ayerdi Oskar , Baza Begoña , Orviz Eva , Antela Antonio , Losada Elena , Riera Melchor , Peñaranda María , Angels Ribas M , Campins Antoni A , Garcia-Gazalla Mercedes , Fanjul Francisco J , Murillas Javier , Homar Francisco , Vilchez Helem H , Martin Luisa , Payeras Antoni , Santos Jesús , López María , Gómez Cristina , Viciana Isabel , Palacios Rosario , López-Cortés Luis Fernando , Espinosa Nuria , Roca Cristina , Llaves Silvia , Tiraboschi Juan Manuel , Imaz Arkaitz , Saumoy María , Curran Adrián , Falcó Vicenç , Navarro Jordi , Burgos Joaquin , Suanzes Paula , García Jorge , Descalzo Vicente , Álvarez Patricia , Planas Bibiana , Sanchíz Marta , Rodríguez Lucía , Monforte Arnau , Vidovic Paola , Olalla Julián , Pérez Javier , del Arco Alfonso , de la Torre Javier , Prada José Luis , Martínez Onofre Juan , Martinez Lorena , Vera Francisco Jesús , García Josefina , Alcaraz Begoña , Guirao Antonio Jesús Sánchez , Mena Álvaro , Pernas Berta , Vázquez Pilar , López Soledad , Castelo Brais , Ibarra Sofía , García Guillermo , Mirena Josu , Ferrero Oscar Luis , López Josefina , de la Peña Mireia , López Miriam , López Iñigo , Lombide Itxaso , Polo Víctor , de Miguel Joana , Estevez Beatriz Ruiz , Aguirre Maite Ganchegui , Gracia María Jesús Barberá , Galera Carlos , Fernández Marian , Albendin Helena , Castillo Antonia , Iborra Asunción , Moreno Antonio , Angustias Merlos M , Chiclano Inmaculada , Amador Concha , Pasquau Francisco , Gil Concepción , Algado José Tomás , Suarez-García Inés , Malmierca Eduardo , González-Ruano Patricia , Pilar Ruiz M , Pascual José Francisco , Balsalobre Luz , Somodevilla Ángela , de la Villa López María , Omar Mohamed , Herrero Carmen , de Zárraga Miguel Alberto , Pérez Desirée , Estrada Vicente , Cabello Noemí , José Núñez M , Sagastagoitia Iñigo , Homen Reynaldo , Muñoz Ana , Yeguas Inés Armenteros , Górgolas Miguel , Cabello Alfonso , Álvarez Beatriz , Prieto Laura , Al-Hayani Aws , Carrillo Irene , Sanz José , Arranz Alberto , Hernández Cristina , Novella María , José Galindo M , Gómez Sandra Pérez , Ferrer Ana , Román Antonio Rivero , Ruíz Inma , Juárez Antonio Rivero , López Pedro , Machuca Isabel , Frias Mario , Camacho Ángela , Pérez Ignacio , Corona Diana , Caballero Javier Manuel , Martinez-Echevarría Rafael Rodríguez-Rosado , Torres Rafael , Sánchez Juan Macías , Rincón Pilar , Real Luis Miguel , Corma Anais , González-Serna Alejandro , Poveda Eva , Pérez Alexandre , Morano Luis , Miralles Celia , Ocampo Antonio , Pousada Guillermo , Gallego María , Alonso Jacobo , Martínez Inés , Dueñas Carlos , Gutiérrez Sara , de la Fuente López Marta , Novoa Cristina , Egües Xjoylin , Telleria Pablo , Fernández Carlos Güerri , Valls Claudia Navarro , Du Juan , Blanco Agustin Marcos , Aldea Itziar Arrieta , Ruan Esperanza Cañas , Canepa Cecilia , Giralt Natalia García 
Published: December 2024

Abstract

Objectives
To evaluate the long-term effectiveness, persistence and tolerability of dolutegravir (DTG)/lamivudine (3TC), compared with the most frequently prescribed first-line treatment regimens, among antiretroviral-naive people with HIV from CoRIS, a multicentre cohort in Spain, in 2018–23.

Methods
We used multivariable regression models to compare viral suppression (VS) (HIV RNA viral load &lt;50 copies/mL), change in CD4 cell counts, persistence and treatment discontinuations due to adverse events (AEs), at 96 (±24) weeks after treatment initiation.

Results
Of 2359 participants, DTG/3TC was prescribed in 472 (20.0%), bictegravir/tenofovir alafenamide (TAF)/emtricitabine (FTC) in 1134 (48.1%), DTG + tenofovir disoproxil fumarate/FTC in 300 (12.7%), DTG/abacavir/3TC in 273 (11.6%) and darunavir/cobicistat/TAF/FTC in 180 (7.6%). At 96 weeks from treatment initiation, 94.0% of participants initiating with DTG/3TC achieved VS, and the mean increase in CD4 cell counts was 295.5 cells/μL (95% CI: 269.9–321.1). During the first 96 weeks after DTG/3TC initiation, 9.8% and 1.3% discontinued their initial regimen, overall and due to AEs, respectively. In multivariable analyses, we did not find significant differences in VS or increase in CD4 cell counts among participants initiating with DTG/3TC compared with other regimens. Initiating ART with a regimen other than DTG/3TC was associated with a higher risk of treatment discontinuation, overall and due to AEs.

Conclusions
Among treatment-naive people with HIV from this large multicentre cohort, DTG/3TC had similar effectiveness and better persistence and tolerability than those of the most frequently prescribed first-line regimens at 96 weeks.