bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficiency of copper extraction from magma bodies: Implications for mineralization potential and fluid-silicate melt partitioning of copper
Authors: Zhou Jin-Sheng , Wang Qiang , Wyman Derek A. , Zhao Zhen-Hua , Zhang Le , He Peng-Li 
Published: September 2021

Abstract
Multiple factors may downgrade the mineralization potential of an intermediate-felsic intrusion, such as the commonly invoked inefficient fluid exsolution and lack of ore-forming species (metals and their ligands) in magmas. However, other factors may affect the mineralization potential of a magma body but have poorly understood roles in the formation of magmatic-hydrothermal ore deposits. Here, we present a comparison between two Cu mineralizing plutons and a Cu-poor, Fe mineralizing pluton in the Edong district. Efficient fluid exsolution and extraction occurred during the solidification of all three plutons, as evidenced by extensive skarn alteration around them. The results show that the oxidation state of the three plutons is similar (within a range of ~ΔNNO+0.9 to ΔNNO+2.5). A systematic comparison of the Cu contents of a certain suite of minerals of the three plutons shows that the Cu concentrations of all minerals in the Cu mineralizing plutons are lower than those of the Cu-poor Fe mineralizing pluton. This indicates that the Cu mineralizing plutons underwent more efficient copper extraction. Thus, igneous crystals with anomalously low Cu contents may potentially be used as a tool to identify Cu mineralizing magmatic units in a deposit with multiphase intrusions. We suggest that the inefficient copper extraction from plutons may be ascribed to the lack of reduced S species during fluid exsolution or different evolution paths of Cu and Cl during magma crystallization.
Controls on tetrahedral Fe(III) abundance in 2:1 phyllosilicates—Reply
Authors: Cuadros Javier , Michalski Joseph R. , Dyar M. Darby 
Published: September 2021

AbstractThe model of Fe3+ distribution between octahedra and tetrahedra in dioctahedral smectites by Decarreau and Petit (2014) used data from infrared analysis. From their own and other general evidence, the resulting data are likely to be affected by significant uncertainty. This aside, their model has limited application because it is based on synthetic smectites containing only Si, Al, and Fe3+.
New Mineral Names,
Authors: Belakovskiy Dmitriy I. , Uvarova Yulia 
Published: September 2021

Abstract

In this issue
This New Mineral Names has entries for 11 new species, including bohuslavite, fanfaniite, ferrierite-NH4, feynmanite, hjalmarite, kenngottite, potassic-richterite, rockbridgeite-group minerals (ferrirockbridgeite and ferrorockbridgeite), rudabányaite, and strontioperloffite.
Copula-based modeling of hydraulic structures using a nonlinear reservoir model
Authors: Tan Qiaofeng , Mao Yunze , Wen Xin , Jin Tian , Ding Ziyu , Wang Zhenni 
Published: September 2021

Abstract
Multivariate flood frequency analysis has been widely used in the design and risk assessment of hydraulic structures. However, analytical solutions are often obtained based on an idealized linear reservoir model in which a linear routing process is assumed, and consequently, the flood risk is likely to be over- or underestimated. The present study proposes a nonlinear reservoir model in which the relationships of reservoir water level with reservoir volume and discharge are assumed to be nonlinear in order to more accurately describe the routing process as it takes into consideration the interactions between hydrological loading and different discharge structures. The structure return period is calculated based on the copula function and compared with that based on the linear reservoir model and the bivariate return period based on the Kendall distribution function. The results show that the structure return period based on the linear model leads to an underestimation of the flood risk under the conditions of high reservoir water level. For the same reservoir, linear and nonlinear reservoir models give quite different reservoir volume-water level and discharge-water level curves; therefore, they differ substantially in the sensitivity to flood events with different combinations of flood peak and volume. We also analyze the effects of the parameters involved in the reservoir volume-water level and discharge-water level relationships on the maximum water level at different return periods in order to better understand the applicability and effectiveness of the proposed method for different hydraulic projects.
Library-independent source tracking of fecal contamination in selected stations and tributaries of Laguna Lake, Philippines
Authors: Abello Joseth Jermaine M. , Malajacan Gicelle T. , Labrador Kevin L. , Nacario Mae Ashley G. , Galarion Luiza H. , Obusan Marie Christine M. , Rivera Windell L. 
Published: September 2021

Abstract
Laguna Lake is the largest inland freshwater body in the Philippines. Although it is classified to be usable for agricultural and recreational purposes by the country's Department of Environment and Natural Resources (DENR), studies looking at lake ecology revealed severe fecal contamination which contributes to the deterioration of water quality. Determining the sources of fecal contamination is necessary for lake protection and management. This study utilized a library-independent method of microbial source tracking (LIM-MST) to identify sources of fecal contamination in selected Laguna Lake stations and tributaries. Genetic markers of the host-associated Escherichia coli, heat-labile toxin (LTIIA) and heat-stable II (STII), were used to identify cattle and swine fecal contaminations, respectively. Meanwhile, human mitochondrial DNA (mtDNA) was used to identify human fecal contamination. Results identified the presence of agricultural and human fecal contamination in Laguna Lake Stations 1 and 5, Mangangate River, and Alabang River. The selected sites are known to be surrounded by residential and industrial complexes, and most of their discharges find their way into the lake. The identification of the specific sources of fecal contamination will guide management practices that aim to regulate the discharges in order to improve the water quality of Laguna Lake.
Competitive adsorption and mechanism of hexahydroxy metallic system by aminated solution-blown polyacrylonitrile micro/nanofibers
Authors: Lou Huiqing , Li Siyu , Feng Xiangwei , Cao Xianzhong 
Published: September 2021

AbstractAdsorptive properties for Cd(II), Cr(III), Cu(II), Ni(II), Pb(II) and Zn(II) onto amidoxime-functionalized polyacrylonitrile (APAN) micro/nanofibers were systematically investigated in a hexahydroxy metallic solution system using batch experiments. The interactive effect of multi-metal ions in multi- metal systems was antagonistic in nature, and the adsorption capacity in a multi-metal system was lower than that in a single-metal system. The Langmuir isotherm model could explain respectively the isotherm and kinetic experimental data for the hexahydroxy metallic system with much satisfaction. The maximum adsorption capacity in hexahydroxy metallic for Cd(II), Cr(III), Cu(II), Ni(II), Pb(II) and Zn(II) was calculated to be 98 mg/L, 158 mg/L, 80 mg/L, 76, 312 and 58 mg/L individually. The APAN micro/nanofibers possessed good selectivity toward Pb(II) and Cr(III), over Cd(II), Cu(II), Ni(II), and Zn(II), having the highest selectivity coefficients at 17.52 and 6.07 in the test range. The five adsorption-desorption cycle experiments exhibited that APAN micro/nanofibers adsorbent are readily reusable, and have potential for heavy metal removal from wastewater. The adsorption behavior in multi-metal systems was shown to be complex, including surface complexation, antagonistic competition and displacement reactions. The diversity and selectivity in metal ion adsorption onto the micro/nanofibers relate mainly to the stability constants, and the microscopic coupling mechanism between the heavy metal ions and the functional groups on the fiber surface. This interaction mechanism between the favorable component and other metal ions could contribute significantly to the direct displacement impact illustrated schematically.
Socioeconomic potential for rainwater harvesting systems in southern Brazilian municipalities
Authors: Tavares L. C. , Bravo J. M. , Tassi R. , Almeida I. R. , Wartchow D. 
Published: September 2021

Abstract
The implementation of rainwater harvesting (RWH) systems depends on technical and socioeconomic assessments. However, most studies do not consider socioeconomic aspects, which could lead to different degrees of RWH implementation and technology selection due to economic constraints and local regulations. We evaluated the socioeconomic potential for RWH as an alternative for the water supply of 24 southern Brazilian municipalities with less than 50,000 inhabitants. A total of 10,080 RWH configurations were assessed and a reliability analysis was carried out to define the RWH system configurations potentially implementable (RWH+) in each municipality. RWH economic benefits were estimated from a social point of view, based on the reduction of the monthly water payment. Overall, RWH+ supplying higher demands with higher economics savings were feasible, as expected. However, several municipalities that showed RWH+ supplying 100% of the domestic water demands obtained lower economic savings, due to low water tariff and water consumption. Still, a set of municipalities presented RWH+ for rainwater demand replacing 50% to 60% of the residential demand, for which the high water tariffs were reflected in higher economic savings. The advantages of using the RWH systems stand out even more when the investments at Federal and Local levels are considered.
The importance of organic carbon as a coadjutant in the transport of pollutants
Authors: Iubel Juliana Pisa Grudzien , Braga Sérgio Michelotto , Braga Maria Cristina Borba 
Published: September 2021

Abstract
Dissolved organic carbon (DOC) is a physicochemical parameter widely used in the evaluation of surface water quality; however, its role as an agent of transport and transference of pollutants sometimes is still disregarded. The heterogeneous composition of DOC, predominantly composed of humin, humic and fulvic acids, renders it an inherent capacity to bind to organic and inorganic pollutants. This is an important feature when the knowledge of present and future conditions of aquatic environments is of concern. Some authors concluded that DOC is a controlling agent of mobility of metals, phosphorus, herbicides, and pesticides, among others. Nevertheless, some physical and chemical conditions in the water column and in the sediment can immobilize the contaminants and make the DOC less soluble, which will hamper the formation of DOC-pollutant complexes. This mini review is intended to present the importance of DOC quantification and some information on its association with water contaminants, which could render them unavailable for uptake.
The Development of 3-substituted Indolin-2-one Derivatives as Kinase
Inhibitors for Cancer Therapy
Authors: Xu Changqing , Liu Yang , Zhao Guisen 
Published: September 2021

:
Kinases are pivotal regulators in tumorigenesis and metastasis by modulating
the expression of oncogenes and the transcription of antioncogenes directly or indirectly.
Correspondingly, multifarious 3-substituted indolin-2-one derivatives as selective kinase
inhibitors for cancer therapy exhibited a low nanomolar activity with prominent efficacy,
superior response rate and admirable tolerability. Particularly, certain 3-substituted indolin-
2-one derivatives have met the requirements for clinical trials or the pharmaceutical
market. Herein, we focus on the traits of 3-substituted indolin-2-one derivatives as kinase
inhibitors for cancer therapy, overview recent progress of 3-substituted indolin-2-one derivatives
as kinase inhibitors for cancer therapy, analyze the selectivity for tyrosine kinases
inhibitors and serine/threonine kinases inhibitors from the molecular aspects based on
the molecular docking studies, summarize the structure-activity relationships (SARs) as
selective kinase inhibitors and provide our perspectives for the development of 3-
substituted indolin-2-one derivatives as kinase inhibitors for cancer therapy.
Multivesicular Liposome: A Lipid-based Drug Delivery System for Efficient Drug Delivery
Authors: Gorain Bapi , Al-Dhubiab Bandar E. , Nair Anroop , Kesharwani Prashant , Pandey Manisha , Choudhury Hira 
Published: September 2021

:
The advancement of delivery tools for therapeutic agents has brought several novel formulations
with increased drug loading, sustained release, targeted delivery, and prolonged efficacy. Amongst the several
novel delivery approaches, multivesicular liposome has gained potential interest because this delivery system
possesses the above advantages. In addition, this multivesicular liposomal delivery prevents degradation of the
entrapped drug within the physiological environment while administered. The special structure of the vesicles
allowed successful entrapment of hydrophobic and hydrophilic therapeutic agents, including proteins and peptides.
Furthermore, this novel formulation could maintain the desired drug concentration in the plasma for a
prolonged period, which helps to reduce the dosing frequencies, improve bioavailability, and safety. This tool
could also provide stability of the formulation, and finally gaining patient compliance. Several multivesicular
liposomes received approval for clinical research, while others are at different stages of laboratory research. In
this review, we have focused on the preparation of multivesicular liposomes along with their application in different
ailments for the improvement of the performance of the entrapped drug. Moreover, the challenges of delivering
multivesicular vesicles have also been emphasized. Overall, it could be inferred that multivesicular liposomal
delivery is a platform of advanced drug delivery with improved efficacy and safety.
The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common
Cancers
Authors: Zhang Qi , Wu Yinxin , Chen Jinlan , Tan Fangshun , Mou Jie , Du Zhuoying , Cai Yuxuan , Wang Bei , Yuan Chengfu 
Published: September 2021

Background:
Muscle blind-like-proteins (MBNL) are a class of tissue-specific RNA metabolism regulators
that control pre-messenger RNA-splicing. Inactivation of MBNL can lead to myotonic dystrophy in
adults. MBNL is mainly expressed in skeletal muscle, neuron tissue, thymus, liver, and kidney and plays an important
role in the ultimate differentiation of muscle cells and neurons. MBNL1 is a member of the MBNL protein
family. The inactivation of MBNL1 protein is particularly important in the development of myotonic dystrophy
and can lead to cataract formation, abnormal muscle relaxation, cardiac and neurological dysfunction,
etc. The induction of MBNL1 in tumors is known to significantly inhibit tumor progression and thus significantly
prolong survival. MBNL1 antisense protein MBNL1-AS1 also plays an important role in tumor migration
and development.

Objective:
This review reveals the role of MBNL1 and MBNL1-AS1 in the complex pathogenesis of many tumors,
which provide a new target for the treatment of tumors.

Methods:
Correlated research are systematically retrieved via PubMed. In this review, the role of MBNL1 and
MBNL1- AS1 were analyzed.

Results:
MBNL1 is down-regulated in breast cancer, leukemia, stomach cancer, esophageal cancer, glioma,
and Huntington's disease. The function of inhibiting tumor cell metastasis decreased. It is up-regulated in cervical
cancer and colorectal cancer, which can promote the development of tumor cells. Antisense protein MBNL1-
AS1 can inhibit tumor cell proliferation and metastasis in colorectal cancer, non-small cell lung cancer, and
gastric cancer.

Conclusion:
MBNL1 is an important regulator of tumor metastasis and growth, which exhibits a promising
therapeutic target and can be further explored.
It is Not Always COVID-19: Case Report about an Undiagnosed HIV Man with Dyspnea
Authors: Pontolillo Michela , Falasca Katia , Vecchiet Jacopo , Ucciferri Claudio 
Published: September 2021

Background:
The current COVID-19 pandemic has attracted great attention from the
medical world. In the past year, there have been reports of missed or delayed treatments for conditions
that mimic COVID-19. The main symptoms caused by SARS-CoV-2, such as fever and
cough, belong to different clinical conditions. It is of the utmost importance that the diagnostic
thinking used to analyze data and information to reach a COVID-19 diagnosis does not overlook
the plethora of different diagnoses related to these symptoms.

Case report:
The aim of this work is to present the clinical case of a patient having unrecognized
HIV infection with a 4-week history of fever, cough, and hypoxia. When tests were allowed to
highlight HIV-related immunodeficiency status, a CMV assay was performed in order to evaluate
opportunistic pneumonia. Through this, diagnosis of HIV combined with CMV pneumonia was
made, thus excluding COVID-19 respiratory insufficiency.

Conclusion:
The diagnosis of the two conditions in the COVID-19 era is challenging due to overlapping
clinical and radiological features and limitations of current diagnostic assays. This causes
clinical implications due to diagnostic delays.
Dental-Facial Midline: An Esthetic Based Classification
Authors: Niraula Nischal , Acharya Reecha , Humagain Manoj , Khurshid Zohaib , Adanir Necdet , Rokaya Dinesh 
Published: September 2021

Background:
The facial midline and dental midline play an important role in facial esthetics, cosmetic dentistry, facial plastic surgery, and anthropologic studies.

Objective:
This study studied the dental-facial midline in Nepalese subjects and to classify the midline.

Methods:
The study was conducted in 150 Nepalese subjects, mostly consisting of University students (80 males and 70 females). After obtaining ethical approval, facial and dental midlines were analyzed using a scale.

Results:
It showed 26 (18%) study subjects showed the coincidence of the facial midline with the maxillary and mandibular dental midlines. It showed that only 44 (30%) subjects showed the coincidence of facial midline with only maxillary dental midline, and 26 (17%) subjects showed the facial midline coincidence with only mandibular dental midline. The dental midline discrepancy was more prevalent in the maxillary arch and more prevalent on the right side. Midline discrepancy is seen more in males compared to females. The majority of the deviation showed 1 mm, followed by 2 mm, and 3 mm.

Conclusion:

The coincidence of the facial midline with both the maxillary and mandibular dental midlines is uncommon. Midline discrepancy is seen more in males compared to females. The majority of the subjects show a mild discrepancy of 1 mm. The midline discrepancy was more seen on the right side and in the maxillary arch.
TikTok as a Health Information Source: Assessment of the Quality of Information in Diabetes-Related Videos
Authors: Kong Wenwen , Song Shijie , Zhao Yuxiang Chris , Zhu Qinghua , Sha Ling 
Published: September 2021

Background
Diabetes has become one of the most prevalent chronic diseases, and many people living with diabetes use social media to seek health information. Recently, an emerging social media app, TikTok, has received much interest owing to its popularity among general health consumers. We notice that there are many videos about diabetes on TikTok. However, it remains unclear whether the information in these videos is of satisfactory quality.

Objective
This study aimed to assess the quality of the information in diabetes-related videos on TikTok.

Methods
We collected a sample of 199 diabetes-related videos in Chinese. The basic information presented in the videos was coded and analyzed. First, we identified the source of each video. Next, 2 independent raters assessed each video in terms of the completeness of six types of content (the definition of the disease, symptoms, risk factors, evaluation, management, and outcomes). Then, the 2 raters independently assessed the quality of information in the videos, using the DISCERN instrument.

Results
In regard to the sources of the videos, we found 6 distinct types of uploaders; these included 3 kinds of individual users (ie, health professionals, general users, and science communicators) and 3 types of organizational users (ie, news agencies, nonprofit organizations, and for-profit organizations). Regarding content, our results show that the videos were primarily about diabetes management and contained limited information on the definition of the disease, symptoms, risk factors, evaluation, and outcomes. The overall quality of the videos was acceptable, on average, although the quality of the information varied, depending on the sources. The videos created by nonprofit organizations had the highest information quality, while the videos contributed by for-profit organizations had the lowest information quality.

Conclusions
Although the overall quality of the information in the diabetes videos on TikTok is acceptable, TikTok might not fully meet the health information needs of patients with diabetes, and they should exercise caution when using TikTok as a source of diabetes-related information.
Thực trạng nghiên cứu bài học và nghiên cứu khoa học của giáo viên trung học phổ thông tại thành phố Cần Thơ
Authors: Nguyễn Kỳ Tuấn Sơn , Diễm Huỳnh Thị Thúy 
Published: September 2021

Nghiên cứu cung cấp thông tin về thực trạng, nguyên nhân, và giải pháp của việc áp dụng nghiên cứu bài học (NCBH) vào sinh hoạt tổ chuyên môn (SHTCM) và nghiên cứu khoa học giáo dục (NCKH) của giáo viên trung học phổ thông (GVTHPT) đang công tác tại một số trường ở thành phố Cần Thơ. Kết quả khảo sát và phân tích định tính cùng định lượng 431 GVTHPT cho thấy việc áp dụng NCBH đã được thực hiện đại trà hơn 6 năm, nhưng NCBH vẫn chưa được GVTHPT hiểu đúng đắn và đầy đủ ý nghĩa khi thực hiện. Việc áp dụng NCBH vào SHTCM vẫn chưa được GVTHPT thực hiện theo đúng quy trình và đúng nguyên tắc của NCBH từ khâu tập huấn, chuẩn bị giáo án cho đến khâu dự giờ, quan sát và phản hồi. Một số GVTHPT chưa hài lòng với việc tập huấn về hình thức và nội dung của lí thuyết NCBH và họ muốn được tập huấn về NCBH chuyên sâu, thực hành nhiều hơn với và có được những trải nghiệm thực tế và hoạt động thực tế. Bên cạnh đó, kết quả khảo sát hoạt động NCKH đặc biệt là NCKHGD của GVTHPT rất yếu. Khoảng 62.41% GVTHPT chưa từng thực hiện NCKHGD hoặc nếu có thì cũng chỉ thực hiện sáng kiến kinh nghiệm. Chính vì thế NCBH sẽ phải được tập huấn bài bản và trực tiếp từ những chuyên gia...
Hiệu quả xử lý nước thải nuôi cá trê vàng (Clarias macrocephalus) thâm canh bằng hệ thống thực vật thủy sinh
Authors: Nguyễn Thị Hồng Nho , Phú Trương Quốc , Liêm Phạm Thanh 
Published: September 2021

Nghiên cứu được thực hiện nhằm tìm ra loài thực vật thủy sinh có khả năng xử lý tốt chất thải trong hệ thống tuần hoàn nuôi trồng thủy sản. Thí nghiệm gồm 4 nghiệm thức trồng bèo tai tượng (Pistia stratiotes), bèo tấm (Lemna minor), bèo nhật (Limnobium laevigatum) và nghiệm thức đối chứng (không trồng thực vật) thực hiện trong hệ thống tuần hoàn trong 15 ngày. Cá trê vàng có khối lượng trung bình 60 g/con được nuôi trong hệ thống tuần hoàn với mật độ 70 con/100L và cho ăn thức ăn viên nổi (41% protein). Kết quả nghiên cứu cho thấy bèo tai tượng xử lý tốt hầu hết các chất ô nhiễm trong nước thải nuôi cá trê vàng trong 10 ngày đầu thí nghiệm. Bèo tai tượng có khả năng làm giảm 65,83% CO2; 34,28% COD; 40,70% TAN; 46,70% N-NO3- 24,56 % P-PO43-; và 9,16% TP và làm tăng 37,68% oxy hòa tan trong nước thải so với nồng độ ban đầu.