bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of Karst Floods with a Hydrological Model Improved by Meteorological Model Coupling
Authors: Li Ji , Yuan Daoxian , Ma Mingguo , Liu Jiao 
Published: December 2021

Abstract
Karst basins are prone to rapid flooding because of their geomorphic complexity and exposed karst landforms with low infiltration rates. Accordingly, simulating and forecasting floods in karst regions can provide important technical support for local flood control. The study area, the Liujiang karst river basin, is the most well-developed karst areas in South China, and its many mountainous areas lack rainfall gauges, limiting the availability of precipitation information. Quantitative precipitation forecast (QPF) from the Weather Research and Forecasting (WRF) Model and quantitative precipitation estimation (QPE) from the Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks–Cloud Classification System (PERSIANN-CCS) can offer reliable precipitation estimates. Here, the distributed Karst–Liuxihe (KL) model was successfully developed from the terrestrial Liuxihe model, as reflected in improvements to its underground structure and confluence algorithm. Compared with other karst distributed models, the KL model has a relatively simple structure and small modeling data requirements, which are advantageous for flood prediction in karst areas lacking hydrogeological data. Our flood process simulation results suggested that the KL model agrees well with observations and outperforms the Liuxihe model. The average Nash coefficient, correlation coefficient, and water balance coefficient increased by 0.24, 0.19, and 0.20, respectively, and the average flood process error, flood peak error, and peak time error decreased by 13%, 11%, and 2 h, respectively. Coupling the WRF Model and PERSIANN-CCS with the KL model yielded a good performance in karst flood simulation and prediction. Notably, coupling the WRF and KL models effectively predicted the karst flood processes and provided flood prediction results with a lead time of 96 h, which is important for flood warning and control.

Significance Statement
The WRF Model and PERSIANN-CCS can provide precipitation data for mountainous karst areas lacking rainfall gauges, and their rainfall results are forecasted effectively to reduce the uncertainty of input precipitation data. Then, the PERSIANN-CCS QPEs and WRF QPF are coupled with the improved KL model for karst flood simulation and prediction. This coupled model worked well in karst basins.
Low Cloud Detection in Multilayer Scenes Using Satellite Imagery with Machine Learning Methods
Authors: Haynes John M. , Noh Yoo-Jeong , Miller Steven D. , Haynes Katherine D. , Ebert-Uphoff Imme , Heidinger Andrew 
Published: December 2021

Abstract
The detection of multilayer clouds in the atmosphere can be particularly challenging from passive visible and infrared imaging radiometers since cloud boundary information is limited primarily to the topmost cloud layer. Yet detection of low clouds in the atmosphere is important for a number of applications, including aviation nowcasting and general weather forecasting. In this work, we develop pixel-based machine learning–based methods of detecting low clouds, with a focus on improving detection in multilayer cloud situations and specific attention given to improving the Cloud Cover Layers (CCL) product, which assigns cloudiness in a scene into vertical bins. The random forest (RF) and neural network (NN) implementations use inputs from a variety of sources, including GOES Advanced Baseline Imager (ABI) visible radiances, infrared brightness temperatures, auxiliary information about the underlying surface, and relative humidity (which holds some utility as a cloud proxy). Training and independent validation enlists near-global, actively sensed cloud boundaries from the radar and lidar systems on board the CloudSat and CALIPSO satellites. We find that the RF and NN models have similar performances. The probability of detection (PoD) of low cloud increases from 0.685 to 0.815 when using the RF technique instead of the CCL methodology, while the false alarm ratio decreases. The improved PoD of low cloud is particularly notable for scenes that appear to be cirrus from an ABI perspective, increasing from 0.183 to 0.686. Various extensions of the model are discussed, including a nighttime-only algorithm and expansion to other satellite sensors.

Significance Statement
Using satellites to detect the heights of clouds in the atmosphere is important for a variety of weather applications, including aviation weather forecasting. However, detecting low clouds can be challenging if there are other clouds above them. To address this, we have developed machine learning–based models that can be used with passive satellite instruments. These models use satellite observations at visible and infrared wavelengths, an estimate of relative humidity in the atmosphere, and geographic and surface-type information to predict whether low clouds are present. Our results show that these models have significant skill at predicting low clouds, even in the presence of higher cloud layers.
Association between olfactory dysfunction and COVID-19 severity: A prospective study in a highly complex hospital in Peru
Authors: Alcas Olenka , Saldaña Diego , Triveño Andy , Salazar Miguel , Mejía Paola 
Published: December 2021

Introduction Olfactory dysfunction has been included among the early symptoms of coronavirus disease (COVID-19). Evidence suggests that a relationship exists between the duration of olfaction disorders and the probability of developing severe COVID-19. Given the scope of the COVID-19 pandemic, this study aimed to determine the frequency of smell alteration and its association with the severity of COVID-19 in a referral hospital in Peru, which is one of the most affected countries in the Latin American region. Materials and Methods This study was an observational, prospective cohort study that included patients with COVID-19 who were treated at the Hospital Nacional Edgardo Rebagliati Martins from August to November 2020. To assess the association, the chi-square test of independence or Fisher’s exact test was performed. The outcome variable was COVID-19 severity, and the exposure variable was olfactory dysfunction. The first data collection was in the emergency department and the follow-up was via telephone. Results A total of 179 patients were included. The mean age was 61.6 ± 15.5 years, and 129 patients (72.1%) were male. Olfactory dysfunction was observed in 43 patients (24%). An inverse association was found between age and olfactory dysfunction ( P = .002). No significant association was found between COVID-19 severity level and olfactory alteration ( P = .056). However, a direct association was found between COVID-19 severity and age ( P = .003), cough ( P < .001), and respiratory distress ( P = .003). Conclusion This study did not find any association between the severity of COVID-19 and olfactory dysfunction. It showed a low incidence rate of smell alteration compared with studies from other regions. Moreover, smell alteration was associated with younger age.
Midterm Survivorship of the INBONE II Total Ankle Arthroplasty
Authors: Gagne Oliver J. , Day Jonathan , Kim Jaeyoung , Caolo Kristin , O’Malley Martin J. , Deland Jonathan T. , Ellis Scott J. , Demetracopoulos Constantine A. 
Published: December 2021

Background: The use of total ankle arthroplasty (TAA) in the treatment of ankle arthritis has grown substantially as advancements are made in design and surgical technique. Among the criteria guiding the choice between arthroplasty and arthrodesis, the long-term survival and postoperative outcomes are of crucial importance. Although outcomes of the INBONE I have been published, there is limited midterm survival data for the INBONE II. The purpose of this study was to determine the radiographic and patient-reported outcomes, and survivorship of this prosthesis in patients with a minimum 5-year follow-up. Methods: We retrospectively identified 51 ankles (46 patients) from 2010 to 2015 who underwent TAA with the INBONE II prosthesis at our institution. Of these, 44 cases had minimum clinical follow-up of 5 years (mean, 6.4; range 5-9). Median age was 66 years (range 42-81) and median BMI was 27.5 (range 20.1-33.0). A chart review was performed to record the incidence of revision and reoperation. Preoperative and postoperative radiographs were analyzed to assess the coronal tibiotalar alignment (TTA), the talar inclination angle, and the presence of periprosthetic lucencies and cyst formation. Preoperative and minimum 5-year postoperative Foot and Ankle Outcome Score (FAOS) subscales were compared. Survivorship was determined by incidence of revision, defined as removal of a metallic component. Results: The survivorship at 5 years was 98% and the rate of reoperation was 7.8% (n = 4); 2 patients underwent irrigation and debridement for infection, 1 patient underwent a medializing calcaneal osteotomy, and 1 patient underwent open gutter debridement, 1 patient underwent a revision of a subsided talar component at 3.2 years after index surgery. Average postoperative TTA was 88.6 degrees, with 42 rated as neutral (85-95 degrees), 2 varus (<85 degrees), and no valgus (>95 degrees) ankles. At final follow-up, asymptomatic periprosthetic cysts were observed in 8 patients. All FAOS domain scores improved between preoperative and final follow-up. Conclusion: At midterm follow-up, we observed significant improvement in radiographic alignment and patient-reported outcome scores for the INBONE II total ankle prosthesis. In addition, this cohort has had a relatively low reoperation rate and high survivorship. Level of Evidence: Level IV, case series.
Caution in Using the Activated Partial Thromboplastin Time to Monitor Argatroban in COVID-19 and Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT)
Authors: Guy Susan , Kitchen Steve , Makris Michael , M. Maclean Rhona , Saccullo Giorgia , Vanveen Joost J 
Published: December 2021

Introduction Argatroban is licensed for patients with heparin-induced thrombocytopenia and is conventionally monitored by activated partial thromboplastin time (APTT) ratio. The target range is 1.5 to 3.0 times the patients’ baseline APTT and not exceeding 100 s, however this baseline is not always known. APTT is known to plateau at higher levels of argatroban, and is influenced by coagulopathies, lupus anticoagulant and raised FVIII levels. It has been used as a treatment for COVID-19 and Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT). Some recent publications have favored the use of anti-IIa methods to determine the plasma drug concentration of argatroban. Methods Plasma of 60 samples from 3 COVID-19 patients and 54 samples from 5 VITT patients were tested by APTT ratio and anti-IIa method (dilute thrombin time dTT). Actin FS APTT ratios were derived from the baseline APTT of the patient and the mean normal APTT. Results Mean APTT ratio derived from baseline was 1.71 (COVID-19), 1.33 (VITT) compared to APTT ratio by mean normal 1.65 (COVID-19), 1.48 (VITT). dTT mean concentration was 0.64 µg/ml (COVID-19) 0.53 µg/ml (VITT) with poor correlations to COVID-19 baseline APTT ratio r2 = 0.1526 p <0.0001, mean normal r2 = 0.2188 p < 0.0001; VITT baseline APTT ratio r2 = 0.04 p < 0.001, VITT mean normal r2 = 0.0064 p < 0.001. Conclusions We believe that dTT is a superior method to monitor the concentration of argatroban, we have demonstrated significant differences between APTT ratios and dTT levels, which could have clinical impact. This is especially so in COVID-19 and VITT.
Thrombotic and Hemorrhagic Incidences in Patients After Discharge from COVID-19 Infection: A Systematic Review and Meta-Analysis
Authors: Rungjirajittranon Tarinee , Owattanapanich Weerapat , Leelakanok Nattawut , Sasijareonrat Natthaporn , Suwanawiboon Bundarika , Chinthammitr Yingyong , Ruchutrakool Theera 
Published: December 2021

Background The association between coronavirus infection 2019 (COVID-19) and thrombosis has been explicitly shown through numerous reports that demonstrate high rates of thrombotic complications in infected patients. Recently, much evidence has shown that patients who survived COVID-19 might have a high thrombotic risk after hospital discharge. This current systematic review and meta-analysis was conducted to better understand the incidence of thrombosis, bleeding, and mortality rates among patients discharged after COVID-19 hospitalization. Methods Using a search strategy that included terms for postdischarge, thrombosis, and COVID-19, 2 investigators independently searched for published articles indexed in the MEDLINE, Embase, and Scopus databases that were published before August 2021. Pooled incidences and 95% confidence intervals were calculated using the DerSimonian-Laird random-effects model with a double arcsine transformation. Results Twenty articles were included in the meta-analysis. They provided a total of 19 461 patients discharged after COVID-19 hospitalization. The weighted pooled incidence of overall thrombosis among the patients was 1.3% (95 CI, 0. 6-2; I2 90.5), with a pooled incidence of venous thrombosis of 0.7% (95 CI, 0. 4-1; I2 73.9) and a pooled incidence of arterial thrombosis of 0.6% (95 CI, 0. 2-1; I2 88.1). The weighted pooled incidences of bleeding and mortality were 0.9% (95 CI, 0. 1-1.9; I2 95.1) and 2.8% (95 CI, 0. 6-5; I2 98.2), respectively. Conclusions The incidences of thrombosis and bleeding in patients discharged after COVID-19 hospitalization are comparable to those of medically ill patients.
Twelve-Month Outcomes From the Japanese Post-Market Surveillance Study of the Viabahn Endoprosthesis as Treatment for Symptomatic Peripheral Arterial Disease in the Superficial Femoral Arteries
Authors: Iida Osamu , Ohki Takao , Soga Yoshimitsu , Suematsu Nobuhiro , Nakama Tatsuya , Yamaoka Terutoshi , Tobita Kazuki , Ichihashi Shigeo 
Published: December 2021

Purpose: To assess the midterm safety and effectiveness of the Gore® Viabahn® Endoprosthesis as treatment for symptomatic peripheral arterial disease (PAD) in the superficial femoral arteries (SFA). Materials and Methods: A prospective, multicenter, post-market surveillance study was conducted in Japan. Patients with symptomatic SFA lesions ≥ 10 cm and reference vessel diameters ranging from 4.0 to 7.5 mm were eligible for enrollment; patients with traumatic or iatrogenic vessel injury in the thoracic, abdominal, or pelvic arteries were excluded. Outcomes evaluated at 12 months were primary patency (PP), primary-assisted patency (PAP), secondary patency (SP), freedom from target lesion revascularization (fTLR), occurrence of device- or procedure-related serious adverse events (SAEs), and stent fractures. Results: From August 2016 to May 2017, 321 patients were enrolled at 64 Japanese sites (mean age, 73.9±8.7 years; 77.3% male). Hypertension, diabetes, and end stage renal disease were present in 84.4%, 54.8%, and 23.1% of patients, respectively. Mean lesion length was 23.6 cm±6.6 cm, with lesions ≥ 15 cm in 271 patients (84.4%). TASC C/D lesions accounted for 86.6% (39.1% TASC C, 47.5% TASC D); 26.5% had critical limb ischemia. Baseline ABI was 0.60±0.16. A total of 562 devices were implanted in 324 limbs, with a majority of patients (68.8%) receiving 2 stents. Through 12 months, 92.1% of patients were evaluable. Kaplan-Meier-estimated PP, PAP, and SP at 12 months was 85.6%, 91.7%, and 94.8%, respectively. Twelve-month fTLR was 92.3%. Mean change in ABI at 12 months was 0.343±0.21; mean improvement in Rutherford class was 2.5. Device- or procedure-related SAEs occurred in 3.1% through 30 days, with a majority of early SAEs consisting of access complications. Through 12 months, a cumulative 10.6% had device- or procedure-related SAEs, with the most common being device occlusions in 4.0%. Lower limb amputation occurred in 0.9% and was related to pre-existing ulceration or gangrene in all 3 cases. No stent fractures were observed at 12-month x-ray evaluation. Conclusion: In a real-world Japanese patient population characterized by long SFA lesions and complex PAD, the Viabahn endoprosthesis was associated with excellent patency rates through 12 months and an acceptable safety profile.
Systemic Inflammation Response Index as a Prognostic Marker in Cancer Patients: A Systematic Review and Meta-Analysis of 38 Cohorts
Authors: Zhou Qian , Su Si , You Wen , Wang Tao , Ren Tong , Zhu Lan 
Published: December 2021

Background The systemic inflammation response index (SIRI), a novel and cost-effective serum biomarker, is associated with prognosis in patients with cancer. However, the prognostic value of the SIRI in cancer remains unclear. This study aimed to evaluate the potential role of the SIRI as a prognostic indicator in cancer. Methods Reports in which the prognostic value of the SIRI in cancer was evaluated were retrieved from electronic databases. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated to evaluate the prognostic significance of the SIRI. The odds ratio (OR) was also calculated to explore the association between the SIRI and clinicopathological features. Results This study included 30 retrospective studies with 38 cohorts and 10 754 cases. The meta-analysis indicated that a high SIRI was associated with short overall survival (OS) (HR = 2.04, 95% CI = 1.82–2.29, P < .001) and disease-free survival (DFS)/recurrence-free survival (RFS)/progression-free survival (PFS) (HR = 2.08, 95% CI = 1.84–2.34, P < .001). Subgroup analysis showed that the prognostic value of the SIRI was significant in all kinds of cancer included. Moreover, the SIRI was significantly correlated with sex, tumor size, T stage, N stage, TNM stage, and lymphovascular invasion. Conclusion The pretreatment SIRI could be a promising universal prognostic indicator in cancer.
Understanding perspectives and choices for sedentary behaviour and physical activity in older adults’ post-acute exacerbation of chronic obstructive pulmonary disease
Authors: Chang Chevonne , Wong John , Kamari Ahmad Iqbal , Hui Cheah Sophia C , Chan Mark A , Zainuldin Rahizan 
Published: December 2021

Background Individuals recovering from acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are most likely to exhibit sedentary behaviour (SB) and low levels of physical activity (PA). This study seeks to explore their choices for adopting current patterns of SB and PA post AECOPD and add to current literature on stable COPD. Method A semi-structured interview, based on the broad framework of the Behaviour Change Wheel, was conducted on patients post AECOPD. A phenomenological approach was utilised inductively. Results Six participants were interviewed at their homes. Four major themes were identified: (1) low perceived capabilities for engaging in PA; (2) limited understanding on COPD and PA; (3) lack of translation of health knowledge and intentions into actions; and (4) poor adherence to movement-advice from physiotherapist. Conclusion Our findings revealed largely psychological and behavioural deficits influencing SB and PA in people post AECOPD, similar to those in stable COPD.
Closed-loop audit of muscle sampling in Trans-Urethral Resection of Bladder Tumour
Authors: Varma Raghav , Deb Abdalla , Roy Dorina , Ahmed Ali 
Published: December 2021

Introduction: Our experience with the presence of detrusor muscle (DM) following Trans-Urethral Resection of Bladder Tumour (TURBT). Objectives: To evaluate the presence of DM in primary TURBT specimens as a quality improvement exercise in Frimley Park Hospital, UK. And to assess if the level of the surgeon has impact on outcomes. Methods: Retrospective and prospective analysis of the electronic records from a single urology centre, servicing a group of urologists. Data collected over three consecutive audit loops between January 2014 and May 2018. Results: A total of 301 cases were performed under the care of seven consultant urologists. Analysis revealed a significant improvement in the overall quality of resections from 39% to 66% (50–84% for intermediate and high grade) after the introduction of the following interventions: (1) analysis and improved awareness of current practice; (2) introduction of European Association of Urology (EAU) guidelines by separating samples and sending a second specimen pot marked as bladder tumour base to look for DM; (3) dedicated urologists with an interest in bladder cancer performing en-bloc resection technique in appropriate cases. Conclusion: Through our closed-loop audits, we have demonstrated a considerable improvement in the quality of resections, resulting in accurate staging from the initial resection. This could in turn lead to improved over all prognoses and negating the need for re-resection in all cases of high-risk non-muscle invasive bladder cancer (NMIBC). Level of evidence: 3
A review of the quality and content of mobile apps to support lifestyle modifications following a transient ischaemic attack or ‘minor’ stroke
Authors: O’Connor Seán R , Kee Frank , Thompson David R , Cupples Margaret E , Donnelly Michael , Heron Neil 
Published: December 2021

Objective Secondary prevention is recommended to reduce cardiovascular risk after transient ischaemic attack (TIA) or ‘minor’ stroke. Mobile health interventions can provide accessible, cost-effective approaches to address modifiable risk factors, such as physical inactivity, hypertension and being overweight. The objective of this study was to evaluate the quality of apps for supporting lifestyle change following a TIA or ‘minor’ stroke. Methods Systematic searches of Google Play and the Apple Store were carried out to identify mobile apps released between 1 November 2019 and 1 October 2021. Keywords were used including stroke, TIA, lifestyle, prevention and recovery. Quality was assessed using the Mobile Application Rating Scale (MARS). Common components were identified with the Behaviour Change Technique (BCT) Taxonomy. Descriptive statistics were used to summarize the performance results for each app. Results Searches identified 2545 potential apps. Thirty remained after removing duplicates and screening titles and descriptions. Six were eligible after full review of their content. All apps included at least one BCT (range: 1–16 BCTs). The most frequent BCTs included ‘information about health consequences’ ( n = 5/6), ‘verbal or visual communication from a credible source’ ( n = 4/6) and ‘action planning’ ( n = 4/6). The mean MARS score was 2.57/5 (SD: 0.51; range: 1.78–3.36). No apps were of ‘good’ overall quality (scoring more than 4/5). Conclusions This is the first review of mobile health interventions for this population. Only a small number of apps were available. None were targeted specifically at people with a TIA or ‘minor’ stroke. Overall quality was low. Further work is needed to develop and test accessible, user designed, and evidence-informed digital interventions in this population.