bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postmenopausal Bleeding with an Accidental Discovery of an Ovarian Strumal Carcinoid Tumor: A Case Report
Authors: Ibrahim Eman M. , El Ashwah Salma S. , El-Saeed Fatma I. , Halim Hosam A. F. , Halim Amal A. F. 
Published: March 2021

Aim: Ovarian strumal carcinoid is a tumor formed of thyroid tissue and carcinoid elements. It represents less than 2% of all ovarian tumors and less than 5% of mature teratomas. Physicians in many lacations may not be aware about this pathology.
Presentation of Case: A multiparous 78-year-old woman presented by postmenopausal vaginal bleeding. The abdomen& pelvic sonar detected atrophied endometrium and a right adnexal mass with mixed echogenicity and increased blood flow, a finding that was confirmed later with a pelvic MRI which revealed a well-defined mass of abnormal signal at the right adnexa showing cystic changes contacting anteriorly the related intestinal loops and the urinary bladder, while contacting posteriorly the recto-sigmoid. It measured8x6x6cm. Biopsy revealed atypical epithelial proliferation. CA125 was 90KU/L (normal range,0-35KU/L) while the levels of CEA, CA19-9 and alpha feto protein were normal. After discussion with the family, exploratory hysterectomy and bilateral salpingioophorectomy, along with omentectomy, peritoneal washing and peritoneal sampling were performed. Grossly, the right ovary was largely occupied by an ovoid mass (9cmx6cmx2 cm). The tumor was staged as IA according to AJCC 2010. Histological examination of the adnexal mass revealed admixture of benign thyroid tissue and tumor tissue formed of trabeculae & nests of monotonous round cells. Such cells showed positivity for thyroglobulin, synaptophysin, chromogranin and low positivity for ki67 and so a diagnosis of strumal carcinoid tumor was documented. The patient was set to a close follow up. The last follow up was at August 2020 and was satisfactory.
Discussion and conclusion: Strumal carcinoids are rare. Pelvic sonar and CA125 are not specific diagnostic tools. They should be considered in the differential diagnosis of any ovarian mass. The disease usually presents at an early stage.
Noncompressible Hemostasis and Bone Regeneration Induced by an Absorbable Bioadhesive Self‐Healing Hydrogel
Authors: Huang Weijuan , Cheng Shi , Wang Xiaolan , Zhang Yu , Chen Lingyun , Zhang Lina 
Published: March 2021

AbstractBone bleeding and bone defects arising from trauma or bone tumor resection pose a great threat to patients and they are challenging problems to orthopedic surgeons. Traditional hemostatic materials are not suitable for bone fractures where compression cannot be applied, neither are they effective during surgeries where large amounts of body fluids prevent them from adhering to the large and irregular bone wound sites. This research introduces a catechol‐conjugated chitosan (CHI‐C) multi‐functional hydrogel with adhesion, self‐healing, cytocompatibility, hemocompatibility, and blood cell coagulation capacity. The hydrogel can be injected into internal and irregular bleeding sites and bone defective areas, and then rapidly self‐heals (within 2 min) to an integrated hydrogel that fully fills the defective sites and strongly sticks to bleeding areas in the presence of body fluids during surgery. In vivo experiments using a rabbit ilium bone defect model demonstrate quick hemostasis after the hydrogel is applied and the blood loss is only ¼ compared to the untreated injuries. In addition, the bone regeneration is not interfered by the hydrogel and the bone defect is no longer visible with disappearance of the hydrogel after 4 weeks. This multi‐functional hydrogel is potentially valuable for clinical applications towards tissue adhesion, hemostasis, and bone regeneration.
Tantalum‐Palladium: Hysteresis‐Free Optical Hydrogen Sensor Over 7 Orders of Magnitude in Pressure with Sub‐Second Response
Authors: Bannenberg Lars , Schreuders Herman , Dam Bernard 
Published: March 2021

AbstractHydrogen detection in a reliable, fast, and cost‐effective manner is a prerequisite for the large‐scale implementation of hydrogen in a green economy. Thin film Ta1−yPdy is presented as an effective optical sensing material with extremely wide sensing ranges covering at least 7 orders of magnitude in hydrogen pressure. Nanoconfinement of the Ta1−yPdy layer suppresses the first‐order phase transitions present in bulk and ensures a sensing response free of any hysteresis. Unlike other sensing materials, Ta1−yPdy features the special property that the sensing range can be easily tuned by varying the Pd concentration without a reduction of the sensitivity of the sensing material. Combined with a suitable capping layer, sub‐second response times can be achieved even at room temperature, faster than any other known thin‐film hydrogen sensor.
In Vivo Printing of Nanoenabled Scaffolds for the Treatment of Skeletal Muscle Injuries
Authors: Quint Jacob P. , Mostafavi Azadeh , Endo Yori , Panayi Adriana , Russell Carina S. , Nourmahnad Atousa , Wiseman Chris , Abbasi Laleh , Samandari Mohamadmahdi , Sheikhi Amir , Nuutila Kristo , Sinha Indranil , Tamayol Ali 
Published: March 2021

AbstractExtremity skeletal muscle injuries result in substantial disability. Current treatments fail to recoup muscle function, but properly designed and implemented tissue engineering and regenerative medicine techniques can overcome this challenge. In this study, a nanoengineered, growth factor‐eluting bioink that utilizes Laponite nanoclay for the controlled release of vascular endothelial growth factor (VEGF) and a GelMA hydrogel for a supportive and adhesive scaffold that can be crosslinked in vivo is presented. The bioink is delivered with a partially automated handheld printer for the in vivo formation of an adhesive and 3D scaffold. The effect of the controlled delivery of VEGF alone or paired with adhesive, supportive, and fibrilar architecture has not been studied in volumetric muscle loss (VML) injuries. Upon direct in vivo printing, the constructs are adherent to skeletal muscle and sustained release of VEGF. The in vivo printing of muscle ink in a murine model of VML injury promotes functional muscle recovery, reduced fibrosis, and increased anabolic response compared to untreated mice. The in vivo construction of a therapeutic‐eluting 3D scaffold paves the way for the immediate treatment of a variety of soft tissue traumas.
Hypoxic Tumor Radiosensitization Using Engineered Probiotics
Authors: Huang Chunyu , Wang Fu‐Bing , Liu Lei , Jiang Wei , Liu Wei , Ma Wang , Zhao Huan 
Published: March 2021

AbstractOwing to their ability to rapidly proliferate in specific niches and their amenability to genetic manipulation, bacteria are frequently studied as potential diagnostic or therapeutic bioagents in a range of pathological contexts. A sustained oxygen supply within solid tumors is essential in order to achieve positive radiotherapy (RT) outcomes, as these intratumoral oxygen levels are necessary to facilitate RT‐induced reactive oxygen species (ROS) generation. In this study, a genetically engineered variant of the tumor‐targeting probiotic E. coli Nissle 1917 bacteria that secret catalase is utilized to alleviate intratumoral hypoxia and to thereby enhance tumor radiosensitivity. These engineered bacteria are able to facilitate robust O2 evolution and consequent ROS generation in response to X‐ray irradiation both in vitro and in vivo, significantly inhibiting tumor growth. Overall, the study highlights a novel and practical approach to enhance the efficacy of tumor RT, underscoring the value of future research in the field of probiotic medicine.
Enantioselective Synthesis of α‐Aryl‐β2‐Amino‐Esters by Cooperative Isothiourea and Brønsted Acid Catalysis
Authors: Zhao Feng , Shu Chang , Young Claire M. , Carpenter‐Warren Cameron , Slawin Alexandra M. Z. , Smith Andrew D. 
Published: March 2021

AbstractThe synthesis of α‐aryl‐β2‐amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94 % yield and 96:4 er), with applications to the synthesis of (S)‐Venlafaxine⋅HCl and (S)‐Nakinadine B. Mechanistic studies are consistent with a C(1)‐ammonium enolate pathway being followed rather than an alternative dynamic kinetic resolution process. Control studies indicate that (i) a linear effect between catalyst and product er is observed; (ii) an acyl ammonium ion can be used as a precatalyst; (iii) reversible isothiourea addition to an in situ generated iminium ion leads to an off‐cycle intermediate that can be used as a productive precatalyst.
Antibiotic‐loaded wound dressings obtained from the PBAT‐gentamicin combination
Authors: Scheibel Jóice Maria , Menezes Felipe Castro , Reginatto Camila Leites , de Brito da Silva Cláudia , Moura Dinara Jaqueline , Rodembusch Fabiano , Bussamara Roberta , Weibel Daniel Eduardo , Soares Rosane Michele Duarte 
Published: March 2021

AbstractThe development of biodegradable curative systems containing antibacterial drug are fundamental for the promotion of therapeutic actions, reducing the infections caused by microorganisms and being able to substitute conventional dressings which are not biodegradable polymers in their composition. Meeting those needs, poly (butylene adipate‐co‐terephthalate) (PBAT) and PBAT/gentamicin (GT) fibers were electrospun using different concentrations of GT. The physical–chemical, morphological, thermal, antibacterial, and biological properties of the PBAT and PBAT/GT fibers were characterized. The presence of GT modified the mean diameter, roughness, and wettability of the prepared fibers. The degree of swelling was altered with the addition of GT. PBAT/GT fibers showed antibacterial activity against Escherichia coli strains reaching an inhibitory activity above 90% in the films with 2%, 5%, and 10% of GT. In addition, the fibers did not present cytotoxicity according to ISO 10993‐5 standard. The obtained results reinforce that PBAT can be used as a curative system.
Efficient Ni‐based catalysts for low‐temperature reverse water‐gas shift (RWGS) reaction
Authors: Deng Lidan , Ai Xin , Xie Fengqiong , Zhou Guilin 
Published: March 2021

AbstractCO2 hydrogenation for syngas can alleviate the pressure of un‐controlled emissions of CO2 and bring enormous economic benefits. Advantageous Ni‐catalysts have good CO2 hydrogenation activity and high CO selectivity merely over 700 °C. Herein, we introduced Cu into Ni catalysts, which were evaluated by H2‐TPR, XRD, BET, in‐situ XPS and CO2‐TPD, and their CO2 hydrogenation activity and CO selectivity were significantly affected by the Ni/Cu ratios, which was rationalized by the synergistic effect of bimetallic catalysts. In addition, the reduction temperatures of studied catalysts apparently affected the CO2 hydrogenation, which were caused by the number and dispersion of the active species. It's found that the Ni1Cu1‐400 had good stability, high CO selectivity (up to 90%), and fast formation rate (1.81×10−5 mol/gcat/s) at 400 °C, which demonstrated a good potential as a superior catalyst for reverse water‐gas shift (RWGS) reaction.
Recent Progress and Application Challenges of Wearable Supercapacitors
Authors: Ren Ming , Di Jiangtao , Chen Wei 
Published: March 2021

AbstractThe rapid development of wearable electronics has accelerated the development of wearable energy storage devices. Wearable supercapacitors have aroused widely interest due to their large power density. However, there are still many challenges in the practical application of wearable supercapacitors. This paper summarizes the structure, working mechanism, materials and key parameters of wearable supercapacitors. And we reviewed the challenges of wearable supercapacitors in practical applications, namely safety, mechanical adaptability, self‐charging capability, environmental tolerance, and multifunction. Finally, these challenges are summarized and prospected. We hope to inspire some work to solve the practical application challenges of wearable supercapacitors.
Harnessing Multiple, Nonproteogenic Substitutions to Optimize CSP:ComD Hydrophobic Interactions in Group 1 Streptococcus pneumoniae
Authors: Milly Tahmina A. , Engler Emilee R. , Chichura Kylie S. , Buttner Alec R. , Koirala Bimal , Tal‐Gan Yftah , Bertucci Michael A. 
Published: March 2021

AbstractStreptococcus pneumoniae (pneumococcus) is a human pathobiont that causes drastic antibiotic‐resistant infections and is responsible for millions of deaths universally. Pneumococcus pathogenicity relies on the competence‐stimulating peptide (CSP)‐mediated quorum‐sensing (QS) pathway that controls competence development for genetic transformation and, consequently, the spread of antibiotic resistance and virulence genes. Modulation of QS in S. pneumoniae can therefore be used to enervate pneumococcal infectivity as well as minimize the susceptibility to resistance development. In this work, we sought to optimize the interaction of CSP1 with its cognate transmembrane histidine kinase receptor (ComD1) through substitution of proteogenic and nonproteogenic amino acids on the hydrophobic binding face of CSP1. The findings from this study not only provided additional structure–activity data that are significant in optimizing CSP1 potency, but also led to the development of potent QS modulators. These CSP‐based QS modulators could be used as privileged scaffolds for the development of antimicrobial agents against pneumococcal infections.
Reversible Addition of Carbon Dioxide to Main Group Metal Complexes at Temperatures about 0 °C
Authors: Koptseva Tatyana S. , Sokolov Vladimir G. , Ketkov Sergey Yu. , Rychagova Elena A. , Cherkasov Anton V. , Skatova Alexandra A. , Fedushkin Igor L. 
Published: March 2021

AbstractThe reaction of dialane [LAl‐AlL] (1; L=dianion of 1,2‐bis[(2,6‐diisopropylphenyl)imino]acenaphthene, dpp‐bian) with carbon dioxide results in two different products depending on solvent. In toluene at temperatures of about 0 °C, the reaction gives cycloadduct [L(CO2)Al‐Al(O2C)L] (2), whereas in diethyl ether, the reaction affords oxo‐bridged carbamato derivative [L(CO2)(Et2O)Al(μ‐O)AlL] (3). The DFT and QTAIM calculations provide reasonable explanations for the reversible formation of complex 2 in the course of two subsequent (2+4) cycloaddition reactions. Consecutive transition states with low activation barriers were revealed. Also, the DFT study demonstrated a crucial effect of diethyl ether coordination to aluminium on the reaction of dialane 1 with CO2. The optimized structures of key intermediates were obtained for the reactions in the presence of Et2O; calculated thermodynamic parameters unambiguously testify the irreversible formation of the product 3.
Metal‐Organic Framework Materials for Light Hydrocarbon Separation
Authors: Fu Mingyue , Wang Yutong , Wang Xiaokang , Sun Daofeng 
Published: March 2021

AbstractIn practical industrial applications, the separation of light hydrocarbon mixtures is a very important technology. In recent years, some progress has been made in metal‐organic framework materials for light hydrocarbon separation, but further research is still needed. This Minireivew presents a systematic discussion on the latest developments and separation mechanisms of metal‐organic framework materials for C2 and C3 mixtures, discusses the problems faced by metal‐organic framework materials in the study of light hydrocarbon adsorption and separation, and provides a reference for the design, preparation and process development of low‐carbon hydrocarbon adsorption and separation materials in the future.
Exploring the Electronic Properties of Extended Benzofuran‐Cyanovinyl Derivatives Obtained from Lignocellulosic and Carbohydrate Platforms Raw Materials
Authors: Ibrahim Nagham , Moussallem Chady , Allain Magali , Segut Olivier , Gohier Frédéric , Frère Pierre 
Published: March 2021

AbstractTwo series of linear extended benzofuran derivatives associating cyanovinyl unit and phenyl or furan moieties obtained from benzaldehyde‐lignocellulosic (Be series) or furaldehyde –saccharide (Fu series) platforms were prepared in order to investigate their emission and electrochemical properties. For the fluorescence in solution and solid states, contrasting results between the two series were demonstrated. For Be series a net aggregation induced emission effect was observed with high fluorescence quantum yield for the solid state. A [2+2] cycloaddition under irradiation at 350 nm was also revealed for one derivative of Be series. In contrast, for Fu series the fluorescence in solution is higher than in the solid state. The X‐ray crystallography studies for the compounds reveal the formation of strong π‐π stacking for the derivatives without emissive property in the solid state and the presence of essentially lateral contacts for emissive compounds. Taking advantage of the propensity to develop 2D π‐stacking mode for the more extended derivative with a central furan cycle, organic field effect transistors presenting hole mobility have been made.
A Self‐Conditioned Metalloporphyrin as a Highly Stable Cathode for Fast Rechargeable Magnesium Batteries
Authors: Abouzari‐Lotf Ebrahim , Azmi Raheleh , Li Zhenyou , Shakouri Shirin , Chen Zhi , Zhao‐Karger Zhirong , Klyatskaya Svetlana , Maibach Julia , Ruben Mario , Fichtner Maximilian 
Published: March 2021

AbstractDevelopment of practical rechargeable Mg batteries (RMBs) is impeded by their limited cycle life and rate performance of cathodes. As demonstrated herein, a copper‐porphyrin with meso‐functionalized ethynyl groups is capable of reversible two‐ and four‐electron storage at an extremely fast rate (tested up to 53 C). The reversible four‐electron redox process with cationic‐anionic contributions resulted in a specific discharge capacity of 155 mAh g−1 at the high current density of 1000 mA g−1. Even at 4000 mA g−1, it still delivered >70 mAh g−1 after 500 cycles, corresponding to an energy density of >92 Wh kg−1 at a high power of >5100 W kg−1. The ability to provide such high‐rate performance and long‐life opens the way to the development of practical cathodes for multivalent metal batteries.
Comparative study of oncologic efficacy of cephalomedial to lateral dissection versus medial to lateral dissection in laparoscopic total mesorectal excision for rectal cancer: An RCT study
Authors: Hong Hi‐Ju , Zhao Xuan , Yu Chao‐Ran , Sun Jing , Dong Feng , Zang Lu , Lu Ai‐Guo , Feng Bo , Wang Ming‐Liang , Yu Min‐Hao , Qiu Zheng‐Jun , Qian Bi‐Yun , Xie Li , Fingerhut Abe , Zheng Min‐Hua , Ma Jun‐Jun , Zhong Min 
Published: March 2021

AbstractBackground and ObjectivesWe compared the 3‐year overall survival between cephalomedial‐to‐lateral approach proctectomy (CEMP) and medial‐to‐lateral approach proctectomy (MAP) in patients undergoing laparoscopic total mesorectal excision for rectal cancer. The advantages of CEMP and the clinical value of No. 253 lymph nodes resection have not been objectively analyzed in literature.MethodsThis was a prospective, two‐arm, multicenter, single‐blinded, randomized trial. The primary endpoint was 3‐year overall survival, and secondary endpoints included safety, feasibility, oncological radicality (including number of No. 253 lymph nodes harvested), short‐term outcome, 3‐year disease‐free survival, rate of postoperative complications, mortality, and rate of recurrence.ResultsFrom May 2016 to July 2020, 506 patients were enrolled—256 in the CEMP group and 250 in the MAP group. Comparison of overall survival and disease‐free survival showed that there was treatment benefit in the CEMP group (28.22 ± 12.12 vs. 27.44 ± 13.06, p = 0.485; 27.24 ± 12.01 vs. 26.42 ± 12.81; p = 0.457). More No. 253 lymph nodes were harvested in the CEMP group, and cases with positive No. 253 lymph nodes had worse prognosis in stage III. Surgical safety was equal for both approaches.ConclusionsDissection of No. 253 lymph nodes may be important to improve clinical prognosis, but further studies with larger samples are needed to confirm this finding.
On a weighted trace embedding and applications to critical boundary problems†
Authors: Ferreira L. C. F. , Furtado M. F. , Medeiros E. S. , da Silva J. P. P. 
Published: March 2021

AbstractWe prove a weighted Sobolev trace embedding in the upper half‐space and give its best constant. This embedding can be employed to study a number of critical boundary problems. In this direction, we obtain existence and nonexistence results for a class of semilinear elliptic equations with nonlinear boundary conditions involving critical growth. These equations are closely related to the study of self‐similar solutions for nonlinear reaction‐diffusion equations.
Sleep disorders in children with asthma
Authors: Reiter Joel , Ramagopal Maya , Gileles‐Hillel Alex , Forno Erick 
Published: March 2021

AbstractAsthma and sleep disorders are both common in childhood, and often co‐exist in the same child. Moreover, studies have shown that in many children the rate of one is influenced by the other. Sleep disorders can be classified into six different groups—insomnia, hypersomnia, parasomnia, movement disorders, circadian disorders, and sleep‐related breathing disorders. Children with asthma often present with complaints of insomnia with poor sleep quality, difficulty falling asleep and sleep disruptions. These complains are often associated with asthma control. They may also complain of daytime sleepiness and have higher rates of parasomnias, such as night terrors and nocturnal enuresis when compared with their healthy peers. Whether movement and circadian disorders are also more prevalent in children with asthma is less clear. Finally, there is a complex bidirectional interaction between sleep‐related breathing disorders and asthma: poor sleep and sleep disorders may worsen asthma, and asthma, particularly when it is poorly controlled, may impair sleep.In the current review we examine the association of each of the sleep disorders with asthma and review the common pathophysiological pathways. We hope to convince the reader that appropriate management of asthma must include inquiries into the patient's sleep, and vice versa.
Thermo‐Kinetic Investigation of the Preparation of Micronized Ammonium Perchlorate Particles by Using Rapid Cooling Crystallization Method
Authors: Zinab Javad Mohebbi , Hosseini Seyed Ghorban , Tavangar Saeed , Bahri Mohammad Mahdi 
Published: March 2021

AbstractProduction of micronized ammonium perchlorate particles (AP) (<25 μm) has a great importance in the composite solid propellant industry. In the present study, an attempt was made to consider thermo‐kinetic preparation of AP particles by using simple McCabe model in a cooling crystallization system. For this reason, an experimental design based on temperature, pressure, time, and concentration was used. Temperature in the range of 323–343 K, pressure in the range of 3
–18
Pa, and concentration in the range of 0.4–0.5 g/mL were set for the experiments. The time parameter was variable regarding to the temperature and concentration of each experiment and it was measured to evaluate the rate of process. The crystal size as an experiment response was estimated using image analysis of produced samples by MIP software in micrometer scale. Finally, a growth rate equation was established considering the results obtained from temperature variations, pressure, concentration, and time. Decrease in temperature variations caused to increase in crystallization rate and crystal size. The pressure above 7.5
Pa resulted in producing crystals smaller than 40 μm. The lowest crystal size was observed in the concentration of 0.45–0.5 g/mL and the crystallization time below 8 s. In addition, the results obtained from presented equation and experiment were matched with McCabe model.