bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing NF-κB Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage
Authors: Jameson Tom S O , Pavis George F , Dirks Marlou L , Lee Benjamin P , Abdelrahman Doaa R , Murton Andrew J , Porter Craig , Alamdari Nima , Mikus Catherine R , Wall Benjamin T , Stephens Francis B 
Published: March 2021

AbstractContextThe early events regulating the remodeling program following skeletal muscle damage are poorly understood.ObjectiveThe objective of this study was to determine the association between myofibrillar protein synthesis (myoPS) and nuclear factor-kappa B (NF-κB) signaling by nutritionally accelerating the recovery of muscle function following damage.Design, Setting, Participants, and InterventionsHealthy males and females consumed daily postexercise and prebed protein-polyphenol (PP; n = 9; 4 females) or isocaloric maltodextrin placebo (PLA; n = 9; 3 females) drinks (parallel design) 6 days before and 3 days after 300 unilateral eccentric contractions of the quadriceps during complete dietary control.Main Outcome MeasuresMuscle function was assessed daily, and skeletal muscle biopsies were taken after 24, 27, and 36 hours for measurements of myoPS rates using deuterated water, and gene ontology and NF-κB signaling analysis using a quantitative reverse transcription PCR (RT-qPCR) gene array.ResultsEccentric contractions impaired muscle function for 48 hours in PLA intervention, but just for 24 hours in PP intervention (P = 0.047). Eccentric quadricep contractions increased myoPS compared with the control leg during postexercise (24–27 hours; 0.14 ± 0.01 vs 0.11 ± 0.01%·h-1, respectively; P = 0.075) and overnight periods (27–36 hours; 0.10 ± 0.01 vs 0.07 ± 0.01%·h-1, respectively; P = 0.020), but was not further increased by PP drinks (P &gt; 0.05). Protein-polyphenol drinks decreased postexercise and overnight muscle IL1R1 (PLA = 2.8 ± 0.4, PP = 1.1 ± 0.4 and PLA = 1.9 ± 0.4, PP = 0.3 ± 0.4 log2 fold-change, respectively) and IL1RL1 (PLA = 4.9 ± 0.7, PP = 1.6 ± 0.8 and PLA = 3.7 ± 0.6, PP = 0.7 ± 0.7 log2 fold-change, respectively) messenger RNA expression (P &lt; 0.05) and downstream NF-κB signaling compared with PLA.ConclusionProtein-polyphenol drink ingestion likely accelerates recovery of muscle function by attenuating inflammatory NF-κB transcriptional signaling, possibly to reduce aberrant tissue degradation rather than increase myoPS rates.
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome
Authors: Toussaint Nicolas , Redhead Yushi , Vidal-García Marta , Lo Vercio Lucas , Liu Wei , Fisher Elizabeth M. C. , Hallgrímsson Benedikt , Tybulewicz Victor L. J. , Schnabel Julia A. , Green Jeremy B. A. 
Published: March 2021

ABSTRACT
Characterising phenotypes often requires quantification of anatomical shape. Quantitative shape comparison (morphometrics) traditionally uses manually located landmarks and is limited by landmark number and operator accuracy. Here, we apply a landmark-free method to characterise the craniofacial skeletal phenotype of the Dp1Tyb mouse model of Down syndrome and a population of the Diversity Outbred (DO) mouse model, comparing it with a landmark-based approach. We identified cranial dysmorphologies in Dp1Tyb mice, especially smaller size and brachycephaly (front-back shortening), homologous to the human phenotype. Shape variation in the DO mice was partly attributable to allometry (size-dependent shape variation) and sexual dimorphism. The landmark-free method performed as well as, or better than, the landmark-based method but was less labour-intensive, required less user training and, uniquely, enabled fine mapping of local differences as planar expansion or shrinkage. Its higher resolution pinpointed reductions in interior mid-snout structures and occipital bones in both the models that were not otherwise apparent. We propose that this landmark-free pipeline could make morphometrics widely accessible beyond its traditional niches in zoology and palaeontology, especially in characterising developmental mutant phenotypes.
The p97–UBXN1 complex regulates aggresome formation
Authors: Mukkavalli Sirisha , Klickstein Jacob Aaron , Ortiz Betty , Juo Peter , Raman Malavika 
Published: March 2021

ABSTRACT
The recognition and disposal of misfolded proteins is essential for the maintenance of cellular homeostasis. Perturbations in the pathways that promote degradation of aberrant proteins contribute to a variety of protein aggregation disorders broadly termed proteinopathies. The AAA-ATPase p97 (also known as VCP), in combination with adaptor proteins, functions to identify ubiquitylated proteins and target them for degradation by the proteasome or through autophagy. Mutations in p97 cause multi-system proteinopathies; however, the precise defects underlying these disorders are unclear. Here, we systematically investigate the role of p97 and its adaptors in the process of formation of aggresomes, membrane-less structures containing ubiquitylated proteins that arise upon proteasome inhibition. We demonstrate that p97 mediates aggresome formation and clearance, and identify a novel role for the adaptor UBXN1 in the process of aggresome formation. UBXN1 is recruited to aggresomes, and UBXN1-knockout cells are unable to form aggresomes. Loss of p97–UBXN1 results in increased Huntingtin polyQ inclusion bodies both in mammalian cells and in a C. elegans model of Huntington's disease. Together, our results identify evolutionarily conserved roles for p97–UBXN1 in the disposal of protein aggregates.
Effect of olanzapine combined with risperidone in the treatment of schizophrenia and its influence on cognitive function
Authors: Yang Lujie , Qi Xia 
Published: March 2021

Objective: To explore the effect of risperidone combined with olanzapine in the treatment of schizophrenia and its influence on cognitive function.
Methods: Ninety-eight schizophrenic patients in our hospital who were admitted and treated between June 2018 and December 2019 were selected. The study group was treated with risperidone combined with olanzapine, and the control group was treated with risperidone. The clinical efficacy, Positive and Negative Syndrome Scale (PANSS) score, Wisconsin Card Sorting Test (WCST) result and adverse reactions of the two groups were compared.
Results: After treatment, the scores of classification completion number and correct times of the observation group were higher than those of the control group, and the scores of the random error number and continuous error number were higher than those of the control group; the differences were statistically significant (P<0.05). The total effective rate of the observation group was 95.56%, which was higher than 77.78% of the control group (P<0.05). After treatment, the PANSS scores of the observation group were significantly lower than those of the control group (P<0.05). The total incidence of adverse reactions in the observation group and control group were 9.30% and 6.98%, respectively, and there was no significant difference between the two groups (P>0.05).
Conclusion: Risperidone combined with olanzapine in the treatment of schizophrenia can effectively reduce symptoms of patients and induce fewer adverse reactions, showing high safety and significant treatment effect.
doi: https://doi.org/10.12669/pjms.37.3.3348
How to cite this:Yang L, Qi X. Effect of olanzapine combined with risperidone in the treatment of schizophrenia and its influence on cognitive function. Pak J Med Sci. 2021;37(3):646-650. doi: https://doi.org/10.12669/pjms.37.3.3348
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
„I tu leży wampir pogrzebany” – powiedzenia, przysłowia, frazeologizmy w przekładach wybranych utworów Andrzeja Sapkowskiego na język rosyjski
Authors: Dziwisz Marcin 
Published: March 2021

And Here Lies a Buried Vampire: Sayings, Proverbs, Idioms in Translations of Selected Works by Andrzej Sapkowski into Russian
This paper elaborates on ways of proverbs and sayings transition, presentin A. Sapkowski’s works, into Russian. Gathered material was discussed from the perspective of both original and translation texts. Analysis covered idiomatic phrases, created by the author, as well as real, existingones, that were subjected to different kinds of modifications in the Polishtext. The presence of this kind of stylistic devices can be considered in a context of realization of the author’s idiolect features in translation text, which makes proper transition of described units so vitally important. It is due to the fact that they become a distinctive feature of Sapkowski style, and should be reflected in the Russian text.
A Mixed-Integer Fractional Optimization Approach to Best Subset Selection
Authors: Gómez Andrés , Prokopyev Oleg A. 
Published: March 2021

We consider the best subset selection problem in linear regression—that is, finding a parsimonious subset of the regression variables that provides the best fit to the data according to some predefined criterion. We are primarily concerned with alternatives to cross-validation methods that do not require data partitioning and involve a range of information criteria extensively studied in the statistical literature. We show that the problem of interest can be modeled using fractional mixed-integer optimization, which can be tackled by leveraging recent advances in modern optimization solvers. The proposed algorithms involve solving a sequence of mixed-integer quadratic optimization problems (or their convexifications) and can be implemented with off-the-shelf solvers. We report encouraging results in our computational experiments, with respect to both the optimization and statistical performance. Summary of Contribution: This paper considers feature selection problems with information criteria. We show that by adopting a fractional optimization perspective (a well-known field in nonlinear optimization and operations research), it is possible to leverage recent advances in mixed-integer quadratic optimization technology to tackle traditional statistical problems long considered intractable. We present extensive computational experiments, with both synthetic and real data, illustrating that the new fractional optimization approach is orders of magnitude faster than existing approaches in the literature.
An Analytic Framework for Effective Public Health Program Design Using Correctional Facilities
Authors: Araz Ozgur M. , Cruz-Aponte Mayteé , Wilson Fernando A. , Hanisch Brock W. , Margalit Ruth S. 
Published: March 2021

We present a decision analytic framework that uses a mathematical model of Chlamydia trachomatis transmission dynamics in two interacting populations using ordinary differential equations. A public health survey informs model parametrization, and analytical findings guide the computational design of the decision-making process. The potential impact of jail-based screen-treat (S-T) programs on community health outcomes is presented. Numerical experiments are conducted for a case study population to quantify the effect and evaluate the cost-effectiveness of considered interventions. Numerical experiments show the effectiveness of increased jail S-T rates on community cases when resources for a community S-T program stays constant. Although this effect decreases when higher S-T rates are in place, jail-based S-T programs are cost-effective relative to community-based programs.Summary of Contribution: Public health programs have been developed to control community-wide infectious diseases and to reduce prevalence of sexually transmitted diseases (STD). These programs can consist of screening and treatment of diseases and behavioral interventions. Public correctional facilities play an important role in operational execution of these public health programs. However, because of lack of capacity and resources, public health programs using correctional facilities are questioned by policy-makers in terms of their costs and benefits. In this article, we present an analytical framework using a computational epidemiology model for supporting public health policy making. The system represents the dynamics of Chlamydia trachomatis transmission in two interacting populations, with an ordinary differential equations-based simulation model. The theoretical epidemic control conditions are derived and numerically tested, which guide the design of simulation experiments. Then cost-effectiveness of the potential policies is analyzed. We also present an extensive sensitivity analyses on model parameters. This study contributes to the computational epidemiology literature by presenting an analytical framework to guide effective simulation experimentation for policy decision making. The presented methodology can be applied to other complex policy and public health problems.
Smart “Predict, then Optimize”
Authors: Elmachtoub Adam N. , Grigas Paul 
Published: March 2021

Many real-world analytics problems involve two significant challenges: prediction and optimization. Because of the typically complex nature of each challenge, the standard paradigm is predict-then-optimize. By and large, machine learning tools are intended to minimize prediction error and do not account for how the predictions will be used in the downstream optimization problem. In contrast, we propose a new and very general framework, called Smart “Predict, then Optimize” (SPO), which directly leverages the optimization problem structure—that is, its objective and constraints—for designing better prediction models. A key component of our framework is the SPO loss function, which measures the decision error induced by a prediction. Training a prediction model with respect to the SPO loss is computationally challenging, and, thus, we derive, using duality theory, a convex surrogate loss function, which we call the SPO+ loss. Most importantly, we prove that the SPO+ loss is statistically consistent with respect to the SPO loss under mild conditions. Our SPO+ loss function can tractably handle any polyhedral, convex, or even mixed-integer optimization problem with a linear objective. Numerical experiments on shortest-path and portfolio-optimization problems show that the SPO framework can lead to significant improvement under the predict-then-optimize paradigm, in particular, when the prediction model being trained is misspecified. We find that linear models trained using SPO+ loss tend to dominate random-forest algorithms, even when the ground truth is highly nonlinear. This paper was accepted by Yinyu Ye, optimization. Supplemental Material: Data and the online appendix are available at https://doi.org/10.1287/mnsc.2020.3922
FILTERING CULTURAL INFLUENCES IN FOREIGN LANGUAGE LEARNING IN THE INDONESIAN CONTEXT: THE CONTROVERSY AND SUGGESTED ACTIONS
Authors: Purnawan Ari 
Published: March 2021

There has been a prolonging controversy on why teachers need to filter the cultural load in foreign language learning. Some educators guarantee that the best way of learning a new language is by presenting the target language situations in the classroom, which usually includes the values, culture, habits, or ways of behaving and thinking of the target language users; however, some others believe that, for the sake of nation’s future and pride, they have to filter and block any influences that come from the value loads. Throughout the long history of foreign language learning approaches and methods, this issue has been one of their hot flavors. In fact, cultural contents are unavoidable in foreign language learning. Therefore, the type of culture to be included in the materials and the goal of study are two important aspects to consider (Kramsch, 2013). The paper aims to present ways that teachers can do to deal with the above issue. Involving culture in a selective manner may become a moderate compromise, and cautious actions in selecting the values to be loaded in the process of teaching and learning needs to be formulated and carefully listed. Some suggested items based on some intensive observations and teacher interviews are presented in the paper. It is expected that the culture issue in English language teaching settings develops into a good awareness of the importance of culture in language learning on the one hand, and of the preservation of own national identity and values on the other hand.
LITERATURE AND HUMAN VALUES: AN EXPERIENCE FROM AN EFL CLASSROOM AT PSU, PATTANI
Authors: Sulaiman Suraiya 
Published: March 2021

Being a rich source of language and culture, literature has been an ideal tool for the study of a language. As literature offers a bountiful and extremely varied body of written material that deals with enduring human issues, it facilitates in enhancing students’ language proficiency as well as expanding their knowledge horizon. Accordingly, literature seems to provide answers for the question posed by the 4th UAD TEFL International Conference: how to teach English in order to boost students’ language proficiency while empowering them with knowledge, skills and attitude in endorsing sustainable development and promoting global awareness. In this article I will share my experience from my literature class at PSU, where I deal with the concerned question. I use two main literary works, A Street Cat Named Bob (2012), a biography by James Bowen and The Kite Runner (2003), a novel by Khaled Hosseini, to teach my students about human values such as love, loyalty, courage and social justice. At the same time, I introduce them to the world’s current issues such as diaspora, immigration, war and the idea of multicultural society.
Ultrasound-guided puncture reduces bleeding-associated complications, regardless of calcified plaque, after endovascular treatment of femoropopliteal lesions, especially using the antegrade procedure: A single-center study
Authors: Fukuda Kentaro , Okazaki Shinya , Shiozaki Masayuki , Okai Iwao , Nishino Akihisa , Tamura Hiroshi , Inoue Kenji , Sumiyoshi Masataka , Daida Hiroyuki , Minamino Tohru 
Published: March 2021

Background
A common complication of endovascular treatment for femoropopliteal lesions is bleeding at the vascular access site. Although risk factors of bleeding-associated complications at the approach site have been reported, the results have been inconclusive. Hence, this study aimed to assess the predictors of bleeding-associated complications at the approach site in patients undergoing endovascular treatment for femoropopliteal lesions.

Methods
This retrospective, single-center, observational study included consecutive patients who underwent endovascular treatment (n = 366, 75% male, 72.4±9.9 year) for peripheral arterial disease with claudication and critical limb ischemia in our hospital from January 2010 to December 2017. We divided the patients into bleeding and non-bleeding groups, depending on whether bleeding-associated complications occurred at the approach site. Bleeding-associated complications were defined according to the Bleeding Academic Research Consortium criteria types 2, 3, and 5.

Results
Altogether, 366 endovascular treatment procedures and 404 arterial accesses were performed for femoropopliteal lesions in 335 peripheral arterial disease patients with claudication and 69 critical limb ischemia patients. We recorded 35 postprocedural bleeding-associated complications at the approach site (9%), all of which were hematomas. The predictors of increased bleeding-associated complications were age ≥ 80 years (bleeding vs. non-bleeding group, 43% vs. 25%, p<0.05) and antegrade cannulation of the common femoral artery (48% vs. 69%, p<0.05). Ultrasound-guided puncture reduced bleeding-associated complications (odds ratio, 0.28; 95% confidence interval, 0.004–0.21; p<0.05). In contrast, there was no significant difference in puncture site calcification between the groups (bleeding vs. non-bleeding groups, 29% vs. 21%, p = 0.29).

Conclusion
Ultrasound-guided puncture is associated with a decrease in bleeding-associated complications at the approach site, regardless of the presence of calcified plaque. It is particularly effective and should be more actively used in patients aged ≥80 years and for antegrade cannulation of the common femoral artery.
Microvascular changes on optical coherence tomography angiography after rhegmatogenous retinal detachment vitrectomy with silicone tamponade
Authors: Lee Ji Hye , Park Young Gun 
Published: March 2021

Purpose
We aimed to evaluate microvascular changes on optical coherence tomography angiography (OCTA) in patients with rhegmatogenous retinal detachment (RRD) who underwent silicone oil (SO) tamponade and compare changes according to macular involvement.

Methods
This retrospective study included 48 patients with unilateral RRD who underwent vitrectomy and SO tamponade and were stable after SO removal. Control data were obtained from the fellow healthy eye. Ophthalmic examinations, including best corrective visual acuity (BCVA) and OCTA, were conducted. Differences in vascular density (VD) in different sections of the macula and differences in the foveal avascular zone (FAZ) were analyzed between the affected eyes and control eyes. Subgroup analyses according to macular involvement were performed.

Results
Baseline BCVA and duration of SO tamponade were associated with postoperative BCVA (p<0.001, p = 0.03, respectively). The average VD in the deep capillary plexus (DCP) and the VD of the nasal parafoveal area in both the superficial capillary plexus (SCP) and the DCP decreased relative to those in the control eyes (p = 0.026, p = 0.028, and p = 0.031, respectively). The FAZ area in the DCP and in the SCP also increased when compared with that in the controls (p = 0.043, p = 0.002, respectively). In addition, the macular-off RRD group had lower VD in the nasal parafoveal area of the DCP than the macular-on RRD group.

Conclusion
SO tamponade could cause microvascular changes, especially in the nasal parafoveal area. The macular-off RRD group were affected more than the macular-on RRD group.
Estimating Collaboration through Variation in Time Series from Members in Group Works
Authors: Hattori Yuto , Harada Fumiko , Shimakawa Hiromitsu 
Published: March 2021

In successful group works, members engage in monitoring where they guess what other members are thinking. Since monitoring promotes self-regulated learning, many teachers try to introduce group works.
This paper proposes a method to inform teachers on the fly of the monitoring status of students in group works using inexpensive and less invasive sensors. In the field of education, the method enables a teacher who supervises many student groups to direct their group works to successful ones.
The method collects accelerations of multiple body parts and pulse waves from each member using sensors. The method uses the singular spectral transformation (SST) to detect the relative changes of each signal in the course of time. When a significant change takes place, it is considered the members get arousal. The method considers group members engage in monitoring when significant changes appear simultaneously among them.
In an experiment to detect successful discussion to integrate ideas from the members into one feasible solution, we have obtained the accuracy of over 0.7. It indicates that the simultaneity of significant changes detected by SST is effective to estimate the monitoring state. In the experiment result, acceleration often worked better than pulse wave signals. It was also found that each member has a different role in the group. The behavior of each member varies with the role of the member. These results show that the method has potential to estimate the monitoring state. They also imply examination of the acceleration of each body parts would enable us to estimate the role of the members. The method allows one teacher to lead many groups to successful group works.