bluuebunny/crossref_metadata_2025_split huggingface dataset:
From absolute nonsense to the world’s operating system
Authors: Werthner Hannes 
Published: October 2021

AbstractInformatics, its artefacts and methods, have fundamentally changed our society and world, from the individual personal level up to the current geo-political powerplay between the US, China and Europe. Information Technology serves as the operating system of our society. This change has happened over the last 30 – 40 years, and the result should be compared with our historic views and expectations. At the same time, despite the enormous success of our discipline, it has serious shortcomings. I discuss some of them, especially the issue of online platforms, and describe a positive “answer”: Digital Humanism. This approach does not only describe and analyze the man – machine relationship, but also underlines the importance of humans in this development: we have to interfere – technology is not god given. This fundamental idea is already supported by a growing number of academics and practitioners from different disciplines and fields.
Untapped Potential for Professional Learning and Development: Kindergarten as a Learning Organization
Authors: Wadel Carl Cato , Knaben Åse Dagmar 
Published: October 2021

AbstractThe importance of professional learning and development for quality in kindergartens has been established in international research. The fact that the kindergarten is a learning organization can be crucial in achieving necessary professional learning. The aim of this study was to investigate what characterizes Norwegian kindergartens as learning organizations. Our research question is: What kind of understanding do kindergarten managers have of a learning organization, what do they believe that a kindergarten must learn about and what do they perceive as characteristics of a learning kindergarten? We have conducted qualitative interviews with five kindergarten managers. The findings point to joint reflection as a key characteristic of a learning kindergarten. However, kindergartens struggle to make reflection a natural part of a day-to-day practice. Consequently, kindergartens fail to utilize an important potential for professional learning. Hence, we conclude that there is an untapped potential for professional learning and development in Norwegian kindergartens.
Experimental investigation on reservoir damage caused by clay minerals after water injection in low permeability sandstone reservoirs
Authors: Zhou Yazhou , Yang Wenbin , Yin Daiyin 
Published: October 2021

AbstractWater injection is an effective method for developing low permeability sandstone reservoirs. In the process of water flooding, reservoir damage can occur due to clay mineral content changes and it will significantly affect oil production. There are few investigations on the changes in clay mineral content and the degree of reservoir damage after injecting the water into low permeability sandstone reservoirs with different permeabilities and lithologies. In this study, low permeability natural cores from different lithological strata were collected from 4 wells in the Daqing sandstone reservoir, and clay mineral components and contents were measured through X-ray diffraction. Changes in the clay mineral content were determined after water injection. The reservoir damage mechanism by clay mineral migration was determined by analyzing scanning electron microscopy (SEM) images after water injection. Meanwhile, the porosity and permeability of the cores were tested after water injection, and the degree of reservoir damage in different lithological strata was determined. The clay mineral content ranges from 6.78 to 14.14% in low permeability sandstone cores and declines by 49.73% after water flooding. Illite, chlorite and illite/smectite mostly decrease, and kaolinite decreases the least. Due to the large particle size of kaolinite, kaolinite migration will block the pore-throats and cause formation damage after water flooding. In argillaceous siltstone and siltstone, kaolinite particles blocking pore-throats are very serious, and the permeability decreases greatly by 21.87–36.89% after water injection. With increasing permeability, the permeability decreases greatly after water injection. The findings of this study can help to better understand the mechanisms of formation damage after injecting water into low permeability sandstone reservoirs.
Secure transmission for cooperative NOMA systems with source‐relay selection
Authors: Xu Shu , Liu Chen , Qian Mujun , Wang Hong , Sun Wenfeng 
Published: October 2021

AbstractBoth cooperative non‐orthogonal multiple access (NOMA) and physical layer security (PLS) are promising techniques for future communication systems. This paper investigates the PLS performance of a cooperative NOMA system where multiple sources transmit a superposed message to two users by utilizing either amplify‐and‐forward (AF) or decode‐and‐forward (DF) relays in both non‐colluding and colluding eavesdropper scenarios. A source‐relay selection scheme is proposed for this system aiming at improving the secrecy performance. Additionally, the closed‐form expression of the secrecy outage probability (SOP) is derived for the proposed source‐relay selection schemes. It is demonstrated that in the proposed schemes, the theoretical results match well with the simulation results. In addition, the proposed schemes outperform the conventional OMA system in terms of SOP.
A new methodology for the analysis and optimal setting of directional polarisation methods for overcurrent elements in line protection applications
Authors: Vaca Sebastián , Fonseca Antonio , Chapi Fernando , Pérez‐Yauli Fabián 
Published: October 2021

AbstractDirectional protection of transmission lines is an important feature in situations where short‐circuit direction must be correctly detected. The proper operation of this protection is highly dependent on phasor comparison techniques called polarisation methods. In practice, there are not clearly defined procedures to analyse and set polarisation methods. Hence, these methods are not normally studied in detail, so their effectiveness is often uncertain. For this reason, this work proposes a novel methodology for analysing the performance of polarisation methods, which includes criteria for the selection of the most appropriate methods and their settings according to each application. Particular phasor diagrams and angular statistics are used for the analysis, while a mathematical optimization problem is defined to determine the best settings of these methods. Based on the benefits that can be obtained, the methodology is intended to be considered as an effective strategy to ensure proper use of polarization methods. The methodology is applied in a portion of the Ecuadorian Transmission System which shows the possibility of studying the performance of polarisation methods. The selection and optimal setting criteria of these methods are also analysed providing opportunities to improve the initial performance of the protection system.
Machine Learning-Based Automated Selection of Regions for Analysis on Bone Marrow Aspirate Smears
Authors: Lewis Joshua , Zhang Xuebao , Shanmugam Nithya , Drumheller Bradley , Shebelut Conrad , Smith Geoffrey , Cooper Lee , Jaye David 
Published: October 2021

Abstract
Manual microscopic examination of bone marrow aspirate (BMA) smears and counting of cell populations remains the standard of practice for accurate assessment of benign and neoplastic bone marrow disorders. While automated cell classification software using machine learning models has been developed and applied to BMAs, current systems nonetheless require manual identification of optimal regions within the slide that are rich in marrow hematopoietic cells. To address this issue, we have developed a machine learning-based platform for automated identification of optimal regions in whole-slide images of BMA smears. A training dataset was developed by manual annotation of 53 BMA slides across biopsy diagnoses including unremarkable trilineal hematopoiesis, acute leukemia, and plasma cell neoplasms, as well as across differences in total cellularity represented by a spectrum of marrow nucleated cell content and white blood cell counts. 10,537 regions among these 53 slides were manually annotated as either “optimal” (regions near aspirate particles with high proportions of marrow nucleated cells), “particle” (aspirate particles), or “hemodilute” (blood-rich regions with high proportions of red blood cells). Training of a neural network-based classifier on 10x magnification slides with region cropping and image augmentation resulted in a classifier with substantial accuracy on new testing-set BMA slides (one-vs-rest AUROC &gt; 0.999 across 10 training/testing splits for all 3 region classes), with very few particle and hemodilute regions being classified as optimal (particle: 0.83%, hemodilute: 0.39%). Additionally, this classifier accurately classifies BMA regions on slides from hematological disorders not represented in the training data, including Burkitt lymphoma (AUROC &gt; 0.999 across region classes), chronic myeloid leukemia (AUROC &gt; 0.999 across region classes), and diffuse large B-cell lymphoma (AUROC = 1 across region classes), demonstrating the broad applicability of our approach. To assess the performance of our classifier on whole-slide images, tiles from 10x magnification slides were manually annotated by three participants with notable concordance (Krippendorff’s alpha = 0.424); substantial agreement was found between manual annotations and model predictions within whole-slide images (optimal AUROC = 0.958, particle AUROC = 1.0, hemodilute AUROC = 0.947). Based on these promising results, this machine learning-based region classification model is being connected to a previously-developed bone marrow cell classifier to fully automate differential cell counting in whole-slide images. The development of this novel automated pipeline has potential to streamline the diagnostic process for hematological disorders while enhancing accuracy and replicability, as well as decreasing diagnostic turnaround time for improving patient care.
Development of B-lymphoblastic leukemia in patients treated for multiple myeloma – A case series of 14 patients
Authors: Abro Brooj , Wang Tianjiao , Hassan Anjum , Ruzinova Marianna , Lee Yi-Shan , Frater John , Parikh Bijal , Wartman Lukas , Kreisel Friederike 
Published: October 2021

Abstract
Development of B-lymphoblastic leukemia/lymphoma (BALL) is uncommon in patients with plasma cell neoplasm (PCN). Currently, little is known about risk factors for and characteristics of BALL arising in patients who have undergone treatment for PCN. We reviewed the clinicopathologic features of 14 patients with PCN who developed subsequent BALL and assessed the clonal relationship between these two neoplasms in 5 of the 14 patients. Clinical and laboratory data were extracted from the electronic medical record in accordance with an institutional review board-approved protocol. For the IgH clonality studies DNA was extracted from formalin fixed paraffin embedded tissue and analyzed utilizing the LymphoTrack® IGH FR2/3 Assay -- S5/PGM™ reagents from Invivoscribe Technologies. Next-generation sequencing of libraries was performed on a ThermoFisher Scientific Ion Torrent S5™ sequencer. The LymphoTrack® Software - S5/PGM™ Version 2.4.5 was used to analyze the IGH rearrangement sequences and relative proportion of the sequences was determined as a percentage of total sequencing reads. All PCN patients in our cohort received an autologous stem cell transplant (auto-SCT) with subsequent lenalidomide maintenance therapy. The mean time from the start of lenalidomide treatment after auto-SCT to BALL development was 62 months. None of the BALL cases were Philadelphia chromosome-positive. There was increased incidence of TP53 mutations and deletions (36%). IgH clones were identified in all but one sample. Comparison of the IgH clones from the original PCN and subsequent BALL revealed distinct clones in all 5 patients tested. In 2 of the 5 patients, the original PCN clone was also identified along with the distinct BALL clone. Our study reveals that BALL cases arising in patients with treated PCN are not clonally related to the original disease, and may represent therapy-related malignancy associated to prior treatment including lenalidomide maintenance therapy. More studies are needed to establish the incidence and understand the pathogenesis of this possible therapy-related complication.
Aspiration pneumonia complicated by disseminated fungal sepsis in the setting of incidental esophagitis cystica: A rare autopsy case report with review of the literature
Authors: Albayrak N 
Published: October 2021

Abstract

Introduction/Objective
Esophageal retention cysts are presumed to arise from obstruction of the excretory ducts of the submucosal glands of the esophagus. Since the first description by Kuhne in 1899, different terminologies have been used to denote these lesions including retention cysts, mucocele, esophagitis cystica, and cyst of esophageal submucosal gland duct. Esophageal retention cysts are generally benign, asymptomatic and discovered incidentally. However, a few studies have reported symptomatic dysphagia and to date, only one autopsy case report described esophageal retention cysts contributing to aspiration pneumonia and cause of death.

Methods/Case Report
We present a case of aspiration pneumonia, associated with both reduced oropharyngeal tone secondary to alcohol consumption and esophageal dysphagia due to esophagitis cystica in a 69 year old female with alcohol use disorder complicated by alcoholic liver disease. The patient was found unresponsive at home with bloody oral secretions and evidence of head trauma. On autopsy all lung lobes demonstrated that large and small airways and alveoli were filled with vegetable matter, associated with prominent bacterial and fungal forms. EVG stain demonstrated vascular disruption with red blood cell extravasation, next to a focus of aspiration pneumonia. This explained the patient’s “bloody oral secretions”, originating from the respiratory tract. Demonstration of fungal hyphae in sections from lungs as well as necrotic colon was consistent with disseminated fungal sepsis. While sections from esophagus showed no varices which could explain the patient’s “bloody oral secretions” in the setting of alcoholic liver disease, there were numerous dilated esophageal submucosal cysts. Cysts were lined by a single to double layer of cuboidal epithelium with eosinophilic cytoplasm and basally-located, bland-appearing nuclei.

Conclusion
In summary, we present a rare case of esophageal retention cyst associated aspiration pneumonia complicated by pulmonary hemorrhage, adding to the growing body of knowledge regarding fatal complications of these usually incidental lesions.
Histopathologic spectrum of glomangioma: A clinico-pathologic review
Authors: Kilapandal Venkatraman S , Braun A , Miller I , Reddy V , Gattuso P 
Published: October 2021

Abstract

Introduction/Objective
Glomus tumors are mesenchymal neoplasms with glomus body type modified smooth muscle cell differentiation. Most glomus tumors have a benign clinical course. However, rarely, they display malignant histologic features.

Methods/Case Report
We undertook a retrospective study using a natural language search in CoPath to find surgical pathology cases from 1993-2020 containing “glomus” in the pathology diagnosis. All relevant cases were included, and clinicopathologic data were reviewed in detail.

Results (if a Case Study enter NA)
A total of 66 tumors were identified, of which 42 were in female (63.6%) and 24 in male (36.4%) patients. The age at surgery ranged from 22 to 79 years with a median of 47.5. Females were significantly younger than males at presentation (p=0.025) by 8.8±3.8 years. Forty cases (60.6%) were located on the digits, 24 in nonvisceral soft tissue of extremities, trunk, and lip (36.4%), and one each in stomach and breast parenchyma. Sixty-three (95.5%) were benign (of which one recurred locally), 2 (3%) were malignant, and 1 (1.5%) was atypical. Four (6%) were multicentric. One case showed mixed histology (oncocytic and classic features) and one was classified as glomangiomatosis. The malignant cases each presented with a single tumor in lower extremity soft tissue in female patients (aged 33 and 49 years). The tumors measured 0.5 and 1.8 cm respectively and showed marked cytologic atypia in both and increased mitotic activity in the first. They were both completely excised.

Conclusion
The majority of glomus tumors are benign, however 3% are malignant. The most common location is the digits, followed by soft tissue. This tumor is more commonly seen in female patients. Unusual histologic variants such as glomangiomatosis and oncocytic component at times may create some difficulty to reach the diagnosis, especially on small biopsies. Unusual locations such as stomach can lead to a wrong diagnosis such as carcinoid, especially in a small biopsy material.
Sex Differences in Proximal Thoracic Aortic Disease Pathology: A Call to Action
Authors: Sadaf H , Zhao B , Lelenwa L , Buja L , Segura A , Cecchi A , Milewicz D M , Safi H , Estrera A 
Published: October 2021

Abstract

Introduction/Objective
Sex disparity is reported across all forms of cardiovascular diseases. Only few studies have focused on sex differences in thoracic aortic disease pathology. We aim to identify and understand sex differences in this patient group to bridge the knowledge gap and improve clinicopathologic outcomes.

Methods/Case Report
This is a retrospective analysis of 83 proximal thoracic aortic aneurysm and dissection (TAAD) cases treated at a single quaternary care center in 2019. Chart review was done for demographics. Consensus criteria (Stone JR et al. Cardiovasc Pathol 2015; 24:267-78; Halushka MK et al. Cardiovasc Pathol 2016; 25:247-57) and a scoring system (Waters KM et al. Cardiovasc Pathol 2017; 30:6-11) were used for pathology reporting. Clinical correlation was also made. Pearson’s chi-square test was used for statistical analysis.

Results (if a Case Study enter NA)
83 patients (61 male and 22 female) were retrieved. Overall thoracic aortopathy was higher among males, accounting for 73.4% of individuals with TAAD. In a subgroup analysis, there was no sex difference in dissection, aortic root involvement, and bicuspid aortic valve (p&gt;0.05). Genetic aortopathy was more prevalent in females than males (27.2% vs 9.8%, p=0.04) alongside early age at first aortic event (median age: 31y vs 52y). Histopathologically, females had frequent translamellar mucoid extracellular matrix accumulation (45.4% vs 22.9%, p=0.04), extensive (54.5% vs 27.8%, p=0.02) and severe (59% vs 34.4%, p=0.04) elastic fiber fragmentation, higher band like (9% vs 6.5%, p&gt;0.05) plus extensive (13.6% vs 4.9%, p&gt;0.05) smooth muscle nuclei loss, and extensive (13.6% vs 1.6%, p=0.01) plus dense (4.5% vs 1.6%, p&gt;0.05) laminar medial collapse than males.

Conclusion
In our patient population, females have a lower prevalence of thoracic aortic disease treated with open repair. However, those who develop TAAD harbor a greater burden of wall pathology and probable worse outcomes. We recommend sex-based analysis of all research on thoracic aortic diseases.
Proficiency Testing Performance for Point of Care Glucose Users in a Tertiary Hospital in Kenya
Authors: Mukunya F M , Amayo A A , Ongeso A , Gitau A 
Published: October 2021

Abstract

Introduction/Objective
Introduction: Point of Care (POC) blood glucose measurements are widely used for monitoring diabetes in hospitals. Ensuring quality of POC glucose is important for patient safety. Proficiency testing (PT) where POC users are provided with samples to analyze in the same way as they would patient samples, and the test results are compared with those of peers, is especially important for hospitals with multiple glucose meters where multiple operators with varying levels of education and experience are performing POC glucose analysis.

Objective
To evaluate the performance of POC glucose users at a tertiary hospital in Nairobi, Kenya.

Methods/Case Report
Methodology: The study was conducted at the Kenyatta National Hospital (KNH), an 1800 bed public teaching and referral hospital located in Nairobi, Kenya.Nurses in 46 wards and clinics who use blood glucose machines (BGM) were given low and high glucose quality control (QC) materials to analyze using BGMs like patient samples. The results of each ward were analyzed. Comparison of each participant was made with the group (consensus values) and the central laboratory (assigned values), and graded as acceptable or unacceptable.

Results (if a Case Study enter NA)
Results:Most participants obtained acceptable glucose results but 7.6% and 13% results were unacceptable when consensus values and assigned values were used respectively. Two participants (4.3%) obtained unacceptable with both low and high glucose controls.

Conclusion
The unacceptable results indicate need for improvement, and two BGM users who should be trained and their competency assessed to ensure quality of glucose tests.
Validation of High sensitivity cardiac troponin (HsTnI) – a breakthrough in diagnostic accuracy of acute coronary syndromes
Authors: Dalal S , Petersen J M , Jhala D 
Published: October 2021

Abstract

Introduction/Objective
Cardiac troponin (cTn) testing is an essential component of the diagnostic workup and management of acute coronary syndromes (ACS). Rapid advances in immunoassay technologies has led to the development of high sensitivity troponin (HsTnl) assays with unprecedented analytic sensitivity and precision. These assays are FDA approved and the use of HsTnl assays is recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), the Joint European Society of Cardiology (ESC), the American College of Cardiology (ACC), and the American Heart Association (AHA) in the Fourth Universal Definition of Myocardial Infarction (2018). The incidence of ACS and its mimics in emergency room visits are much more prevalent in veterans due to increased medical comorbidities. We report here our experience with its validation on two Unicel DXI 800 Access Immunoassays as it has not been well published, particularly in a Veterans Healthcare Clinical Laboratory setting.

Methods/Case Report
The quality assurance goal of the validation is to demonstrate that the Unicel DXI 800 Access Immunoassay HsTnl assay performs as expected on two analyzers and can be put into clinical use. Method to method correlation with a validated conventional Troponin I, within run precision, day to day precision, and a linearity study were performed as part of this validation.

Results (if a Case Study enter NA)
For the total of 60 specimens run for the method comparison, Data was plotted and evaluated against EP evaluator, both hsTnI and Troponin I were within the 95% confidence intervals of the method. The linearity study demonstrated results are linear with results as expected. Two levels of cardiac control were tested in a run of 60 replicates each in one day for within run precision, with all results as expected. The day to day precision with three levels of control run daily over 10 days also yielded results as expected.

Conclusion
The HsTnI is a highly accurate, faster test for the detection of ACS allowing earlier detection of smaller infarcts with much better precision, and there by reducing the morbidity and mortality. It allows rapid discharge of the patients with reducing the cost of hospital stay. This is an example of excellence in laboratory practice by extending the best quality laboratory care with proper validation of instrument methods conducive to laboratory workflow.