bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of continuing audiovestibular practice during Covid-19 pandemic
Authors: Yilmaz Oğuz , Bayazit Dilara , Yaman Handan , Mutlu Berna Özge 
Published: January 2021

Abstract
Background
We aimed to evaluate the significance of continuing audiovestibular practice during the Covid-19 pandemic in the audiology clinic of the university hospital.

Methods
The precautions, test procedures, and risk factors associated with the practice of audiology were evaluated. The number and diagnoses of the cases between 23 March and 23 May 2020 were also compared with the results of the same 2 months in 2019 in an attempt to evaluate the alterations in the audiology practice.

Results
The audiology practice has continued during the pandemic, and numerous audiovestibular tests like newborn hearing screening, pure tone and speech audiometry, auditory brainstem response (ABR) test, bedside vestibular assessment, videomystagmography (VNG), caloric test, vestibular evoked myogenic potential (VEMP), computerized dynamic posturography (CDP), video head impulse test (vHIT), intraoperative cochlear implant measurement, and postop cochlear implant fittings were performed. The number of tests has decreased significantly in the course of the pandemic (p < 0.01). No evidence of Covid-19 disease was detected in the audiology staff and patients. In general, no major risk was seen during testing under protective measures except for vestibular testing which induced vomiting and taking out the mask for lip reading during cochlear implant fitting in the elderly.

Conclusion
It is possible to perform audiovestibular tests during the Covid-19 pandemic by wearing necessary protective equipment and disinfecting the potential surfaces. Vomiting during vestibular tests, uncovering the nose and mouth for lip reading, and small-sized test cabins are the main risk factors of contamination in the audiology clinics.
Feasibility of Fitness Tracker Usage to Assess Activity Level and Toxicities in Patients With Colorectal Cancer
Authors: Ward William H. , Meeker Caitlin R. , Handorf Elizabeth , Hill Maureen V. , Einarson Margret , Alpaugh R. Katherine , Holden Thomas L. , Astsaturov Igor , Denlinger Crystal S. , Hall Michael J. , Reddy Sanjay S. , Sigurdson Elin R. , Dotan Efrat , Zibelman Matthew , Meyer Joshua E. , Farma Jeffrey M. , Vijayvergia Namrata 
Published: January 2021

PURPOSE Performance status (PS) is a subjective assessment of patients' overall health. Quantification of physical activity using a wearable tracker (Fitbit Charge [FC]) may provide an objective measure of patient's overall PS and treatment tolerance. MATERIALS AND METHODS Patients with colorectal cancer were prospectively enrolled into two cohorts (medical and surgical) and asked to wear FC for 4 days at baseline (start of new chemotherapy [± 4 weeks] or prior to curative resection) and follow-up (4 weeks [± 2 weeks] after initial assessment in medical and postoperative discharge in surgical cohort). Primary end point was feasibility, defined as 75% of patients wearing FC for at least 12 hours/d, 3 of 4 assigned days. Mean steps per day (SPD) were correlated with toxicities of interest (postoperative complication or ≥ grade 3 toxicity). A cutoff of 5,000 SPD was selected to compare outcomes. RESULTS Eighty patients were accrued over 3 years with 55% males and a median age of 59.5 years. Feasibility end point was met with 68 patients (85%) wearing FC more than predefined duration and majority (91%) finding its use acceptable. The mean SPD count for patients with PS 0 was 6,313, and for those with PS 1, it was 2,925 (122 and 54 active minutes, respectively) ( P = .0003). Occurrence of toxicity of interest was lower among patients with SPD > 5,000 (7 of 33, 21%) compared with those with SPD < 5,000 (14 of 43, 32%), although not significant ( P = .31). CONCLUSION Assessment of physical activity with FC is feasible in patients with colorectal cancer and well-accepted. SPD may serve as an adjunct to PS assessment and a possible tool to help predict toxicities, regardless of type of therapy. Future studies incorporating FC can standardize patient assessment and help identify vulnerable population.
New drugs and new concerns: Gaining insight through Pharmacovigilance of direct acting Anti-Viral’s in chronic HCV patients
Authors: Hashmi Zahid Yasin , Zia Muhammad Qasim , Bajwa Akram , Ahmed Maqsood , Anwer Naveed , Raza Mahwish , Baqar Jaffer Bin 
Published: January 2021

Objective: The study aimed to assess the safety profile of Direct Acting Anti-Viral’s (DAAs) among patients with chronic Hepatitis C Virus (HCV).
Methods: This multicenter, analytical cross-sectional study was conducted in six gastroenterology and Hepatology centers including Liver Center Faisalabad, Allama Iqbal Medical Institute and Liver Center DHQ Hospital Sialkot, Isra Hospital Hyderabad, Allied Hospital Faisalabad and Rehman Medical Institute Peshawar, between May 2018 and May 2019. The data regarding patient demographics, treatment plan and the frequency of Adverse Events (AEs), and their severity was collected using a pre-designed questionnaire and analyzed through SPSS version 20.0.
Results: A total of 511 HCV patients were enrolled, with an overall male majority. Around 66.3% patients experienced a total of 419 AEs, out of which 61 events were suspected from DAAs while remaining 317 events were associated with Ribavirin. Pyrexia (24.6%) and fatigue (14.8%) were the most commonly reported AEs among patients receiving DAAs. Factors such as Ribavirin-based treatments and the presence of Cirrhosis were more likely to promote AEs occurrence OR [95%CI] i.e. 5.2(2.3-9.1) and 1.9(1.1-3.1) respectively (p < 0.05).
Conclusion: It is concluded from the study results that DAAs have displayed promising outcomes due to the minimal and minor AEs reported.
doi: https://doi.org/10.12669/pjms.37.2.3400
How to cite this:Hashmi ZY, Zia MQ, Bajwa A, Ahmed M, Anwer N, Raza M, et al. New drugs and new concerns: Gaining insight through Pharmacovigilance of direct acting Anti-Viral’s in chronic HCV patients. Pak J Med Sci. 2021;37(2):299-304. doi: https://doi.org/10.12669/pjms.37.2.3400
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case Report: unilateral condylar hyperplasia
Authors: Shetty Shishir , Guddadararangiah Shrihari 
Published: January 2021

Case: This report describes a clinical case of unilateral condylar hyperplasia (CH) with unique, atypical morphology. An important feature of this report is the documentation of a series of clinical photographs of the patient, showing a gradual increase in facial asymmetry associated with the CH. The main symptom reported in this case was facial asymmetry. The main intraoral clinical features observed in the patient were contralateral crossbite and ipsilateral open bite associated with CH. Surgical reshaping of the condyle was the treatment plan for this case. Conclusions: The main take away point from this case is the importance of obtaining previous photographs of the patient at different ages during case diagnosis, which helps the clinician to determine the approximate time of commencement of CH. This case also highlights the imaging features of rarely observed atypical shape of the hyperplastic condyle.
Inventory in Times of War
Authors: Jola-Sanchez Andres F. , Serpa Juan Camilo 
Published: January 2021

Using data from 38,916 businesses in war-torn Colombia and from 5,138 attacks by the two rebel groups, FARC and ELN, we study how firms manage inventory during civil war. We obtain exogenous variation in the conflict intensity via a difference-in-differences model, which hinges on the peace process between Colombia’s government and FARC. Relying on this identification strategy, we hypothesize and show that war causes two effects on firm-level inventories. First, it leads firms to replace physical assets (inventory) with fungible assets (cash), causing them to operate with an oversecured financial buffer, but a fragile operational buffer. Second, this inventory reduction occurs mostly in unprocessed inventories (finished-goods inventories are insensitive to violence), meaning that, although war-torn businesses are equipped to fulfill planned orders, they become inflexible at handling uncertain future demand. We then show that the magnitude of these effects is highly contingent on the firm’s position in the supply chain, its proximity to distribution markets, and the type of attacks it is subject to. We then propose policies to address war-related risk in supply chains. This paper was accepted by Vishal Gaur, operations management.
Reflections on the Evolution of Operations Management
Authors: Graves Stephen C. 
Published: January 2021

In this paper, I provide some observations on how the academic field of operations management has changed over the past 40 years. For this purpose, I have identified and classified the operations management (OM) papers published in Management Science in 1976 and in 2016. From this review, I comment on what’s changed, what’s new, and what we might see in the future. In reflecting on these changes, I also document and discuss how the OM editorial structure and mission have evolved at Management Science over this time. This paper was accepted by David Simchi-Levi, Special Section of Management Science: 65th Anniversary.
Home range, movement and habitat selection of dholes (Cuon alpinus) in Khao Yai National Park, Thailand
Authors: Sukmasuang Ronglarp - , SUKSAVATE WARONG , SONGSASEN NUCHARIN , KHIOWSREE NORASET , CHARASPET KHWANRUTAI , PLA-ARD MANANYA , CHANACHAI YUWALUK , THOMAS WARISARA , SRINOPAWAN KHANCHIT 
Published: January 2021

Abstract. Sukmasuang R, Suksavate W, Songsasen N, Khiowree N, Charaspet K, Pla-ard M, Chanachai Y, Thomas W, Srinopawan K. 2020. Home range, movement and habitat selection of dholes (Cuon alpinus) in Khao Yai National Park, Thailand. Biodiversitas 21: 5915-5926. This study aimed to examine the home range, movement and habitat selection of dholes (Cuon alpinus) in Khao Yai National Park from January 2017 to September 2019 with the objective of studying their movement, diel activity and habitat selection. Based on Autocorrelated Kernel density home range estimation, the results showed that the average home range size of the adult female dhole was 64.6 km2, while the adult male dhole had an average home range size of 132.9 km2. It was found from the monthly analysis that the home range size varied by animal gender and the period of their denning and parenting time. It was also found that the distance traveled by the female dhole was 10.2 km/day, while the male dhole traveled around 19.3 km/day. The overall analysis discovered that the dholes were most active during dawn and dusk. Further, the level of activity increased from May onwards. The grassland and mixed deciduous habitat types significantly affected the selection of the dholes. Case-control linear logistic regression analysis between the distance of the location and habitat types was extremely and positively significant with grassland, which signified the high activity of dhole in the grassland. However, the result was negative with mixed deciduous forest, which was the habitat of the dhole. Autocorrelation functions demonstrated high activity occurred during the early morning and after sunset, which showed that the dholes could adapt for survival in the area, even with recreational activities in the park. The results of this study could contribute to knowledge concerning the species’ movement for long-term species management and conservation.
Der p 1 gene sequence polymorphism in house dust mite Dermatophagoides pteronyssinus
Authors: Adji Aryani , NIODE NURDJANNAH J. , MEMAH VENTJE V. , POSANGI JIMMY , WAHONGAN GRETA J. P. , TALLEI TRINA E. 
Published: January 2021

Abstract. Adji A, Niode NJ, Memah VV, Posangi J, Wahongan GJP, Tallei TE. 2021. Der p 1 gene sequence polymorphism in house dust mite Dermatophagoides pteronyssinus. Biodiversitas 22: 72-78. Gene polymorphisms in Dermatophagoides pteronyssinus (DP) mite can affect the immune response that plays a role in atopic disease. This study aimed to determine the polymorphisms of Der p 1 gene from DP. House dust containing DP was used as a source of DNA containing the Der p 1 gene. The gene was amplified using specific primers DP Der 1 P 108F and DP Der 1 P 1509R. The amplified fragments were cloned using the Toyobo pTA2 vector and sorted then compared with the Gene Bank database. The result shows that there are 8 polymorphism sites in the Der p 1 gene positioned at 190 (GR), 463 (CT), 645 (AR), 751 (CY, CT), 787 (CG), 827 (TA; TW), and 1084 (CG). In the Der p 1 gene, there are 5 silent mutations and 3 nonsynonymous substitutions, resulting in amino acid polymorphisms as follows: Histidine H146 to Tyrosine Y146, Alanine A220 to Valine V220 and amino acid X220, and Tyrosine T232 to Serine S232. Polymorphisms in these amino acids lead to a polarity change, from polar to polar and non-polar to non-polar. These dynamics in polarity does not change the structure or function of the allergen protein. So that they can be used for vaccine design strategies.
El dogmatismo de los literatos
Authors: Sarrión Andaluz José , López Arnal Salvador 
Published: January 2021

A través del presente trabajo se recupera un artículo caído en el olvido del filósofo español Francisco Fernández Buey, que fue publicado originalmente en la revista clandestina Realidad, en 1967. El texto es una interesante muestra del debate estético y político que se producía en el marxismo de la época. A lo largo del texto el autor trata la relación de los escritores y artistas con el compromiso político, desplegando temáticas propias de la época tales como el realismo o la profesionalización del artista. Los editores han trufado el texto original con Notas de Edición a fin de contextualizar el escrito original, y han realizado una labor comparativa entre la versión enviada para su publicación y la que finalmente se publicó clandestinamente, señalando las diferencias entre ambas versiones, diferencias que en ocasiones son sustanciales y muy indicativas de las propias discusiones internas del antifranquismo.
The impact of location variables on the modelling and forecasting of capital expenditure for hyperscale datacenters
Authors: King David 
Published: January 2021

Abstract

The digital age and the growth of the internet is increasing exponentially each year, this has created a need for facilities to house and store the data generated. Examples of the data generated are such items such as images, film libraries such as Netflix and Prime Video along withinternet search data.
The facility to house this information is a data center. A data centeris a building (or self-contained unit within a building) used to house computing equipment such as servers along with associated components such as telecommunications, network and storage systems.
This growth in demand has required data centerproviders to expand into new countries, often at very short notice.

Research Design

The research design will likely use a positivist paradigm with a deductive approach, combining predictive theory and action research theory using a multivariate linear regression technique.
The Data will be collected using closed questionnaires, publicly available data and industry data analysed in a quantitative method with a cross sectional timeline.

Research Findings

Variables will be established and analysed to understand the weighting of each variable and its impact on capital expenditure.

Research Conclusions

The conclusion is expected to be a model where input location variables are used to predict the capital expenditure for the construction of hyperscale data centers.
This will benefit data centerowners, developers and fund providers when assessing the value of capital expenditure required as a decision for investment in selecting a site location fora hyperscale data center.
La accesoriedad cualitativa de la participación
Authors: Martínez-Buján Pérez Carlos 
Published: January 2021

Se analiza la accesoriedad cualitativa de la participación a partir de las novedosas premisas que ofrece la concepción significativa de la acción, elaborada primigeniamente por VIVES ANTÓN, que comporta extraer unas consecuencias que se apartan de las obtenidas por la doctrina y jurisprudencia mayoritarias. En particular, se propone una renuncia no solo a la accesoriedad limitada, sino también a la accesoriedad mínima subjetiva. Se acoge el criterio de la accesoriedad mínima objetiva (accesoriedad lógico-gramatical) y se explican las consecuencias que se derivan de ello. Asimismo, se analiza la cuestión del mantenimiento de un tipo de acción común para autor y partícipe, sin perjuicio de la exigencia de un ataque autónomo del partícipe al bien jurídico, plasmada en un especial elemento subjetivo de la participación. Finalmente, se examina su admisibilidad en el Código penal español
The Revised WIC Food Package and Child Development: A Quasi-Experimental Study
Authors: Guan Alice , Hamad Rita , Batra Akansha , Bush Nicole R. , Tylavsky Frances A. , LeWinn Kaja Z. 
Published: January 2021

BACKGROUND AND OBJECTIVES:The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), one of the largest US safety net programs, was revised in 2009 to be more congruent with dietary guidelines. We hypothesize that this revision led to improvements in child development.METHODS:Data were drawn from a cohort of women and children enrolled in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study from 2006 to 2011 (Shelby County, TN; N = 1222). Using quasi-experimental difference-in-differences analysis, we compared measures of growth, cognitive, and socioemotional development between WIC recipients and nonrecipients before and after the policy revision.RESULTS:The revised WIC food package led to increased length-for-age z scores at 12 months among infants whose mothers received the revised food package during pregnancy (β = .33, 95% confidence interval: 0.05 to 0.61) and improved Bayley Scales of Infant Development cognitive composite scores at 24 months (β = 4.34, 95% confidence interval: 1.11 to 7.57). We observed no effects on growth at age 24 months or age 4 to 6 years or cognitive development at age 4 to 6 years.CONCLUSIONS:This study provides some of the first evidence that children of mothers who received the revised WIC food package during pregnancy had improved developmental outcomes in the first 2 years of life. These findings highlight the value of WIC in improving early developmental outcomes among vulnerable children. The need to implement and expand policies supporting the health of marginalized groups has never been more salient, particularly given the nation’s rising economic and social disparities.
Between a Rock and a Hard Place: Constitutional Conflict Cases before The Romanian Constitutional Court
Authors: Kuti Csongor 
Published: January 2021

For the rule of law-based democratic regimes, at least two types of significant political challenges can be identified:1. Challenges coming from outside of the democratic regime, in the form of movements which, by making use of the constitutionally guaranteed rights and liberties, attempt to destroy the democratic establishment.2. Challenges coming from inside the democratic regime, in the form of authoritarian movements, which are attempting to overcome their political opponents and consolidate their power by the misuse of the institutions found under their control according to the constitutional blueprint.This paper is concerned with the second type of challenges and examines how the power struggle reflects in constitutional adjudication. Focusing on the case law of the Romanian Constitutional Court, it analyzes the trends in the evolution of the Court’s interpretation of constitutional conflict issues. The paper argues that in periods of great political fragmentation and power-struggle, constitutional conflict cases are more present in the Court’s docket and they result in much more disputed decisions, as actors attempt to present political conflicts as judicial ones. The Court itself is getting more drawn into these struggles and gradually loses its ‘independent arbitrator’ stance.
The Association between Polymorphism-119G>A of the Alpha-Fetoprotein Gene and Increased Serum Alpha- Fetoprotein Level: A Case Control Study
Authors: Yavari Mahdieh , Zakeri Saghar , Mazaheri Mahta 
Published: January 2021

Background: Alpha-fetoprotein is produced during pregnancy by the yolk sac, and then by the fetal liver. This hormone is secreted from early pregnancy, but its level of measurement is important from 15 to 21 weeks of gestation. The secretion of this hormone is very important because an increase in this hormone is associated with neural tube defects (NTDs) in the fetus. In this study, we analyzed the association between polymorphism-119G>A in the alpha-fetoprotein (AFp ) gene with increased AFP levels in mothers with no neural tube defects in their fetus.Methods: Participants were 50 pregnant women who had high alpha-fetoprotein but no neural tube defects in their fetus (the case group) and 50 pregnant women that their alpha fetoprotein was normal with no neural tube defects in their fetus (control group). After DNA extraction, the fragment including the desired polymorphism was amplified using the PCR technique, and then sequenced.Results: The results of this study showed that there was no significant relationship between this polymorphism and the increase in alpha fetoprotein in the study population. Conclusion: Future studies are needed to investigate other polymorphisms with higher specimens, and the relationship between this polymorphism, and the survival rate of pregnant mothers in the Iranian population.
Association of -634 C/G Polymorphism at Vascular Endothelial Growth Factor Gene with Risk Retinopathy of Prematurity
Authors: Ghadyani Mohammadamin , Noorishadkam Mahmood , Hosseini-Jangjou Seyed Hamed , Bahrami Reza , Akbarian Elahe , Saeida-Ardekani Maryam , Neamatzadeh Hossein , Zare Zahra 
Published: January 2021

Background: Retinopathy of prematurity (ROP) is a major cause of blindness in newborn infants worldwide. It is well known that neovascularization of the retina is prominent in the proliferative stages of ROP. It is suggested that vascular endothelial growth factor (VEGF) may play a role in the development of ROP. The aim of this study was to evaluate the association of the VEGF -634C/G polymorphism at VEGF with risk of ROP.
Methods: In the study 54 neonates diagnosed with ROP and 55 healthy neonates served as controls. The VEGF -634 C/G polymorphism was genotyped by restriction fragment length polymorphism (PCR-RFLP) technique.
Results: The CC, CG, and GG genotypes of VEGF -634C/G polymorphism were found in 33.3%, 38.9%, and 27.8% of neonates with ROP, respectively. In controls, CC, CG, and GG genotypes were seen in 43.6%, 45.4%, and 10.9%, respectively. Frequency of mutant allele (C) was 52.8% in neonates with ROP and 66.4% in healthy neonates. There was a significant difference in the distribution of VEGF -634C/G polymorphisms between cases and controls. Moreover, there was a significant association between VEGF -634C/G polymorphisms and ROP risk (OR = 3.141, 95% CI 1.115-8.851, P = 0.030).
Conclusion: This study results revealed that VEGF -634C/G polymorphism might serve as a risk factor for development of ROP. Thus, clinicians should be aware of the ROP risk in infant with the VEGF -634C/G polymorphism and ROP risk in infants. However, large sample size and well-designed studies are necessary to validate our findings.