bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptotic behavior of some factorizations of random words
Authors: Zohoorian Azad Elahe , Chassaing Philippe 
Published: December 2021

AbstractIn this paper, we consider the normalized lengths of the factors of some factorizations of random words. First, for theLyndon factorizationof finite random words withnindependent letters drawn from a finite or infinite totally ordered alphabet according to a general probability distribution, we prove that the limit law of the normalized lengths of the smallest Lyndon factors is a variant of the stickbreaking process. Convergence of the distribution of the lengths of the longest factors to a Poisson–Dirichlet distribution follows. Second, we consider thestandard factorizationof randomLyndon word: we prove that the distribution of the normalized length of the standard right factor of a randomn‐letters long Lyndon word, derived from such an alphabet, converges, whennis large, to:in whichdenotes the probability of the smallest letter of the alphabet.
Behavior of steel‐fiber‐reinforced concrete‐filled square steel tube stub columns under eccentric compression
Authors: Huang Dongming , Liu Zhenzhen , Lu Yiyan , Yan Bo 
Published: December 2021

SummaryConcrete‐filled square steel tube (CFSST) stub columns are vital to structural engineering owing to their excellent mechanical properties and architectural benefits. In this study, 42 steel‐fiber‐reinforced CFSST stub columns with different variables are designed to investigate their eccentric compression performance. The variables include the eccentricity ratio (0.08, 0.20, and 0.32), steel fiber volume content (0.0%, 0.6%, 1.2%, and 1.8%), concrete strength (40, 50, and 60 MPa), and square steel tube thickness (3, 3.75, and 4.5 mm). The failure mode, load–lateral deformation characteristics, load–bending moment interaction relationship, and relative load–strain response are investigated experimentally. It is discovered that the use of steel fibers can increase the bearing capacity and improve the ductility of CFSST stub columns. The ABAQUS software is applied to establish and calculate finite element models, and the results of which are consistent with the experimental results. Moreover, a simplified formula to calculate the eccentric ultimate bearing capacity of CFSST stub columns is derived. Under a certain safety margin, the predicted results agree well with the experimental results.
Semi-classical thermodynamics of quantum extremal surfaces in Jackiw-Teitelboim gravity
Authors: Pedraza Juan F. , Svesko Andrew , Sybesma Watse , Visser Manus R. 
Published: December 2021

Abstract
Quantum extremal surfaces (QES), codimension-2 spacelike regions which extremize the generalized entropy of a gravity-matter system, play a key role in the study of the black hole information problem. The thermodynamics of QESs, however, has been largely unexplored, as a proper interpretation requires a detailed understanding of backreaction due to quantum fields. We investigate this problem in semi-classical Jackiw-Teitelboim (JT) gravity, where the spacetime is the eternal two-dimensional Anti-de Sitter (AdS2) black hole, Hawking radiation is described by a conformal field theory with central charge c, and backreaction effects may be analyzed exactly. We show the Wald entropy of the semi-classical JT theory entirely encapsulates the generalized entropy — including time-dependent von Neumann entropy contributions — whose extremization leads to a QES lying just outside of the black hole horizon. Consequently, the QES defines a Rindler wedge nested inside the enveloping black hole. We use covariant phase space techniques on a time-reflection symmetric slice to derive a Smarr relation and first law of nested Rindler wedge thermodynamics, regularized using local counterterms, and intrinsically including semi-classical effects. Moreover, in the microcanonical ensemble the semi-classical first law implies the generalized entropy of the QES is stationary at fixed energy. Thus, the thermodynamics of the nested Rindler wedge is equivalent to the thermodynamics of the QES in the microcanonical ensemble.
Complexity of scalar collapse in anti-de Sitter spacetime
Authors: Frey Andrew R. , Grehan Michael P. , Srivastava Manu 
Published: December 2021

Abstract
We calculate the volume and action forms of holographic complexity for the gravitational collapse of scalar field matter in asymptotically anti-de Sitter spacetime, using numerical methods to reproduce the geometry responding to the oscillating field over multiple crossing times. Like the scalar field pulse, the volume complexity oscillates quasiperiodically before horizon formation. It also shows a scaling symmetry with the amplitude of the scalar field. The action complexity is also quasiperiodic with spikes of increasing amplitude.
Die Virushepatitiden A bis E: Prävalenz, Erregermerkmale und Pathogenese
Authors: Bender Daniela , Glitscher Mirco , Hildt Eberhard 
Published: December 2021

ZusammenfassungBei der viralen Hepatitis handelt es sich um eine akute oder chronische Entzündung der Leber, die durch verschiedene Viren verursacht wird. Weltweit leiden derzeit ca. 325 Mio. Menschen an der chronischen Form. Jährlich versterben insgesamt ca. 1,6 Mio. an den Folgen einer viralen Hepatitis. Die Hepatitisviren werden in 5 Erregergruppen unterteilt, die mit den Buchstaben A bis E bezeichnet werden (HAV–HEV). Diese unterscheiden sich in Phylogenie, Übertragung, Epidemiologie, Wirtsspezifität, Lebenszyklus, Struktur und in speziellen Aspekten der Pathogenese.Das strikt humanpathogene HAV, Teil der Familie Picornaviridae, induziert meist nur akute Hepatitiden und ist primär in Entwicklungsländern verbreitet. Das den Hepeviridae zugeordnete HEV beschreibt eine ähnliche Epidemiologie, ist jedoch durch sein zoonotisches Potenzial auch in Industrienationen weitverbreitet und kann zusätzlich eine chronische Erkrankung induzieren. Eine Chronifizierung tritt ebenso bei dem weltweit verbreiteten HBV (Hepadnaviridae) auf, dessen Satellitenvirus HDV (Kolmioviridae) das vorhandene kanzerogene Potenzial noch einmal erhöht. Das ebenfalls weltweit verbreitete HCV (Flaviviridae) birgt ein äußerst hohes Risiko der Chronifizierung und somit ebenfalls ein stark erhöhtes, kanzerogenes Potenzial.Die Erreger der viralen Hepatitis unterscheiden sich in ihren Eigenschaften und Lebenszyklen. Eine differenzierte Betrachtung im Hinblick auf Epidemiologie, Nachweismethoden und Prävention ist daher angezeigt. Obwohl robuste Therapien, und im Falle einzelner Erreger auch Vakzine, vorhanden sind, muss die Forschung insbesondere in Hinblick auf die armutsassoziierten Erreger erheblich vorangetrieben werden.
Positionspapier Schlaganfallnachsorge der Deutschen Schlaganfall-Gesellschaft – Teil 3: Strukturelle Konzepte für zukünftige Versorgungsformen der Schlaganfallnachsorge
Authors: Schwarzbach Christopher J. , Michalski Dominik , Wagner Markus , Winkler Tobias , Kaendler Stephen , Elstner Matthias , Dreßing Andrea , Claßen Joseph , Meisel Andreas , Grau Armin ,   Mitglieder Kommission Nachsorge der Deutschen Schlaganfall-Gesellschaft
Published: December 2021

Zusammenfassung
Hintergrund
Ungeachtet der großen gesamtgesellschaftlichen Bedeutung des Schlaganfalls sowie der Fortschritte in der Akutversorgung und Rehabilitation konnten bisher keine flächendeckenden Versorgungsstrukturen zur strukturierten ambulanten Nachsorge in Deutschland etabliert werden.

Ziel der Arbeit und Methode
Vor dem Hintergrund der bestehenden Versorgungslücken wurde im Mai 2020 die Kommission Schlaganfallnachsorge der Deutschen Schlaganfall-Gesellschaft (DSG) gegründet. Das Positionspapier diskutiert strukturelle Konzepte für zukünftige Versorgungsformen der Schlaganfallnachsorge.

Ergebnisse und Diskussion
Eine neurologische Betreuung sollte zentraler Bestandteil einer multidisziplinären, interprofessionellen und sektorenübergreifenden Behandlungsplanung sein. Strukturelle Konzepte zur Schlaganfallnachsorge müssen sowohl regionale Strukturunterschiede als auch den Aspekt der Qualitätssicherung berücksichtigen. Zertifizierungsprozesse und die angemessene Finanzierung von Nachsorgeregistern auf Landes- und Bundesebene können den Weg hierhin mittelfristig ebnen. Das Angebot zur strukturierten Schlaganfallnachsorge sollte allen Subgruppen von Schlaganfallpatienten offenstehen. Auch innovative Technologien können einen wichtigen Beitrag zur Schlaganfallnachsorge leisten. Die Einführung und Umsetzung einer strukturierten Schlaganfallnachsorge bedarf in jedem Fall einer ausreichenden Finanzierung und eigener finanzieller Anreize für die Leistungsträger. Die Vor- und Nachteile der spezifischen Versorgungs- und Finanzierungsmodelle müssen dabei kritisch gegeneinander abgewogen werden. Die Diskussion neuer Versorgungsformen zur Schlaganfallnachsorge erfährt gegenwärtig ein neues Momentum und eröffnet Perspektiven für eine Verbesserung der aktuell noch unzureichenden Versorgungslösung.
Context-Dependent Mutation Dynamics, Not Selection, Explains the Codon Usage Bias of Most Angiosperm Chloroplast Genes
Authors: Morton Brian R. 
Published: December 2021

AbstractTwo competing proposals about the degree to which selection affects codon usage of angiosperm chloroplast genes are examined. The first, based on observations that codon usage does not match expectations under the naïve assumption that base composition will be identical at all neutral sites, is that selection plays a significant role. The second is that codon usage is determined almost solely by mutation bias and drift, with selection influencing only one or two highly expressed genes, in particular psbA. First it is shown that, as a result of an influence of neighboring base composition on mutation dynamics, compositional biases are expected to be widely divergent at different sites in the absence of selection. The observed mutation properties are then used to predict expected neutral codon usage biases and to show that observed deviations from the naïve expectations are in fact expected given the context-dependent mutational dynamics. It is also shown that there is a match between the observed and expected codon usage when context effects are taken into consideration, with psbA being a notable exception. Overall, the data support the model that selection is not a widespread factor affecting the codon usage of angiosperm chloroplast genes and highlight the need to have an accurate model of mutational dynamics.
Diverging life cycle patterns of two Diamesa species (Diptera, Chironomidae) in High Arctic streams, Svalbard
Authors: Schütz Stefan Andreas , Brittain John E. , Füreder Leopold 
Published: December 2021

AbstractThe fauna of streams in the High Arctic, dominated by chironomids, is shaped by extreme environmental conditions that represent the physiological limits for benthic invertebrates. Despite their ecological importance, little is known of chironomid life histories, development strategies and the key abiotic drivers limiting larval growth in High Arctic streams. We investigated the larval development and growth in three High Arctic rivers with contrasting water sources, thermal regimes and nutrient characteristics. Populations of the larvae ofDiamesa bohemani(Goetghebuer 1932) andDiamesa aberrata(Lundbeck 1898) from two sampling occasions in July and August 2016 were morphometrically analysed to determine life history patterns and instream productivity. Water temperature differences lead to diverging development patterns on local spatial scales. The lowest larval growth was in a groundwater/snowmelt fed stream with low food concentration and quality, suggesting that stream productivity is not primarily water source dependant, but is dependent on the nutrient supply. Glacially influenced streams are clearly more productive than previously assumed, resulting in comparable secondary production to groundwater/snowmelt-fed streams.
Reproducibility and its confounders of CMR feature tracking myocardial strain analysis in patients with suspected myocarditis
Authors: Fischer Kady , Linder Olivier L. , Erne Sophie A. , Stark Anselm W. , Obrist Sarah J. , Bernhard Benedikt , Guensch Dominik P. , Huber Adrian T. , Kwong Raymond Y. , Gräni Christoph 
Published: December 2021

Abstract
Objectives
Cardiovascular magnetic resonance feature tracking (CMR-FT) is an emerging technique for assessing myocardial strain with valuable diagnostic and prognostic potential. However, the reproducibility of biventricular CMR-FT analysis in a large cardiovascular population has not been assessed. Also, evidence of confounders impacting reader reproducibility for CMR-FT in patients is unknown and currently limits the clinical implementation of this technique.

Methods
From a dual-center database of patients referred to CMR for suspected myocarditis, 125 patients were randomly selected to undergo biventricular CMR-FT analysis for 2-dimensional systolic and diastolic measures, with additional 3-dimensional analysis for the left ventricle. All image analysis was replicated by a single reader and by a second reader for intra- and inter-reader analysis (Circle Cardiovascular Imaging). Reliability was tested with intraclass correlation (ICC) tests, and the impact of imaging confounders on agreement was assessed through multivariable analysis.

Results
Left and right ventricular ejection fractions were reduced in 34% and 37% of the patients, respectively. Good to excellent reliability was shown for 2D (all ICC > 0.85) and 3D (all ICC > 0.70) peak strain and early diastolic strain rate for both ventricles in longitudinal orientation as well as circumferential orientations for the left ventricle. An increased slice number improved agreement while the presence of pericardial effusion compromised diastolic strain rate agreement, and arrhythmia compromised right ventricular agreement.

Conclusion
In a large clinical cohort, we could show CMR-FT yields excellent inter-reader and intra-reader reproducibility. Multi-parametric CMR-FT of the right and left ventricles appears to be a robust tool in cardiovascular patients referred to CMR.
Clinical trial registration.
ClinicalTrials.gov Identifier: NCT03470571, NCT04774549.
Key Points
• Cardiovascular magnetic resonance feature tracking (CMR-FT) is an emerging technique to measure myocardial strain in cardiovascular patients referred for CMR; however, the evaluation of its reproducibility in a large cohort has not yet been performed.
• In a large clinical cohort, CMR-FT yields excellent inter-reader and intra-reader reproducibility for both left and right ventricular systolic and diastolic parameters.
• Arrhythmia and pericardial effusion compromise agreement of select FT parameters, but poor ejection fraction does not.
Manifestations of intraocular inflammation over time in patients on brolucizumab for neovascular AMD
Authors: Khoramnia Ramin , Figueroa Marta S. , Hattenbach Lars-Olof , Pavesio Carlos E. , Anderesi Majid , Schmouder Robert , Chen Yu , de Smet Marc D. 
Published: December 2021

Abstract
Purpose
To describe the adverse events associated with brolucizumab, in particular the sequence of intraocular inflammation (IOI), retinal vasculitis (RV), and/or retinal vascular occlusion (RO).

Methods
This was an unmasked post hoc analysis of the randomized HAWK/HARRIER clinical trials. Patients with neovascular AMD in the brolucizumab arms of the trials were included. IOI-related adverse events reported by study investigators were analyzed to determine early signs and the time course of IOI-related adverse events, using a subgroup of patients with definite/probable IOI cases identified in an independent unmasked post hoc review by an external safety review committee. A limited literature review on IOI following anti-VEGF therapy was also conducted.

Results
Among 50 patients with definite/probable IOI cases identified by the safety review committee, 12 had RV or RO adverse events reported by the investigators. For 6 of 12, IOI (other than RV) was reported before RV or RO. The duration from the first IOI adverse event to the first RV or RO adverse event ranged from 16 to 171 days for 5 patients and was 553 days for 1 patient. Four of the 6 patients received ≥ 1 brolucizumab injection on or after the date of the first IOI adverse event and before the first RV or RO adverse event.

Conclusions
IOI may precede RV or RO in some patients treated with brolucizumab.
Strengthening local volcano observatories through global collaborations
Authors: Lowenstern Jacob B. , Ewert John W. , Lockhart Andrew B. 
Published: December 2021

AbstractWe consider the future of volcano observatories in a world where new satellite technologies and global data initiatives have greatly expanded over the last two decades. Observatories remain the critical tie between the decision-making authorities and monitoring data. In the coming decade, the global scientific community needs to continue to collaborate in a manner that will strengthen volcano observatories while building those databases and scientific models that allow us to improve forecasts of eruptions and mitigate their impacts. Observatories in turn need to contribute data to allow these international collaborations to prosper.
Warum kein Anspruch auf Suizidassistenz?
Authors: Birnbacher Dieter 
Published: December 2021

ZusammenfassungAuch unter Befürwortern der Zulässigkeit einer Suizidassistenz durch Ärzte unter bestimmten Bedingungen besteht weitgehendes Einverständnis darüber, dass kein Arzt zu einer Suizidassistenz rechtlich oder berufsrechtlich verpflichtet sein sollte. Auch das Bundesverfassungsgericht hat in seinem Urteil vom Februar 2020 Suizidwilligen unter bestimmten Bedingungen nicht mehr als ein ungerichtetes in rem-Recht auf Suizidhilfe zugesprochen, das keinen Anspruch gegen einen einzelnen Arzt begründet. Mit dem letzten Satz seines Urteils hat es vielmehr die Freiheit jedes einzelnen Arztes – wie auch jedes anderen potenziellen Helfers –, Nein zu sagen, nachdrücklich bekräftigt. Auf dem Hintergrund einer empirischen Untersuchung der Gründe, die in der Schweiz für die Ablehnung entsprechender Patientenanfragen gegeben werden, untersucht und gewichtet der Beitrag die Gründe, die für diese Freiheit sprechen, unter ethischen Gesichtspunkten und verteidigt ein bedingtes Recht auf Ablehnung gegen dessen jüngste Kritiker. In Fällen, in denen die Bedingungen erfüllt sind, durch die das Bundesverwaltungsgericht in seinem Urteil vom März 2017 „extreme Notlagen“ definiert hat, sollte jedoch zumindest eine moralische Pflicht anerkannt werden, den Patienten an einen Arzt zu verweisen, der zu einer Unterstützung bereit ist.
The neurochemical pathology of schizophrenia: post-mortem studies from dopamine to parvalbumin
Authors: Reynolds Gavin P. 
Published: December 2021

AbstractResearch in Peter Riederer’s lab in Vienna in the late 1970’s came from a strong tradition in post-mortem neurochemical studies, at that time a relatively niche approach in neuroscience research. He was also early to recognise the value of post-mortem brain tissue in elucidating pharmacological mechanisms of neuropsychiatric treatments. I was fortunate to have Peter Riederer as a mentor in my early post-doctoral career; his generous support and the opportunities to use post-mortem brain tissue provided an invaluable grounding on which much of my future research was based. In this paper, I shall provide a brief overview of one trajectory of my research into the neurobiology of schizophrenia that started in the Riederer lab in Vienna investigating dopamine and the D2 receptor. Subsequent research to understand findings of increased dopamine resulted in the identification of reduced GABAergic innervation, culminating in the finding of a deficit in the parvalbumin-containing subtype of GABAergic neurons. Most recent work has been studying how changes in DNA methylation of the parvalbumin gene may relate to these findings in psychotic illness and its animal models.
Comparison of two resilient attachment systems for implant-/mucosa-supported overdentures with a PEKK framework: a clinical pilot study
Authors: Dörsam Istabrak , Hombach Anastasia , Bourauel Christoph , Stark Helmut 
Published: December 2021

Abstract
Objectives
The aim of the study was to determine differences between Locator and CM LOC attachment systems regarding patient satisfaction and wear of the abutments and their inserts. Plaque accumulation onto the polyetherketoneketone (PEKK) framework and polymethylmethacrylate (PMMA) was investigated for the implant-supported overdentures.

Methods
Seventeen edentulous patients were randomised to receive either Locator or CM LOC system for the first year. The total number of implants was 53. After the randomisation, 25 implants received Locator system, and 28 implants received CM LOC system in the first year. After a period of 12 months, the attachment system was exchanged from either Locator to CM LOC or vice versa. Oral Health Impact Profile (OHIP-14) questionnaires were used to evaluate patient satisfaction, chewing comfort, and pressure lesions. Prosthesis hygiene on the PMMA and PEKK surfaces was evaluated by using Stark plaque index. After the exchange of the abutments, they were stored until the end of the 24 months, and the surface wear of the abutments was analysed using a scanning electron microscope.

Results
Three patients (10 implants) died shortly before the end of the first year. Two patients (7 implants) received only Locator system since CM LOC was not indictable for their implant system. Patient’s satisfaction was increased when the attachment system was changed from Locator to CM LOC after 12 months of wearing time. Chewing ability and comfort were increased when the attachment system was changed from CM LOC to Locator after 12-month wearing time. There was no influence of the change of the attachment system on pressure lesions. The observed plaque accumulation was higher on the PMMA than on the PEKK surface. For the 8 investigated Locator abutments, the wear was within low and middle level. For the 28 investigated CM LOC abutments, the wear was within middle and high level for the terminal implants and between low and middle for the central implants (for patients who received 4 implants).

Conclusions
Patient’s satisfaction and wearing comfort can be improved with implant-supported overdentures with CM LOC abutments in comparison to Locator. There was no clear difference between both attachment systems concerning the chewing ability of the patients. Plaque accumulation was observed on both attachment systems in different areas. Plaque accumulation on PEKK surface was less than on PMMA surface.

Clinical relevance
The CM LOC attachment system offers stable and comfortable wearing conditions for implant-supported overdentures. The use of PEKK as a framework material could reduce the incidence of pressure lesions.