bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Model for In Vitro Evaluation of Overlapping Connections between Devices Used in the Endovascular Repair of Popliteal Aneurysms
Authors: Locks Giovani Figueiredo , Mello Roesler Carlos Rodrigo , Horn Françoá Jorge , Gindri Izabelle Mello , Wurdemann Helge , Silveira Pierre Galvagni 
Published: April 2021

Abstract
This work proposes a new methodology to investigate the potential for disconnection (Type III endoleak) of pairs of overlapped endoprostheses in a popliteal model vessel after a cyclic physiologic load, for three different overlap lengths. Multiaxial fatigue accelerated testing was designed to mimic the physiological loads and movements to which the peripheral arteries are submitted during gait. The experiment design was based on principles from technical standards ASTM F2477-07, Standard Test Methods for In Vitro Pulsatile Durability Testing of Vascular Stents (Superseded), and ASTM F2942-13, Standard Guide for In Vitro Axial, Bending, and Torsional Durability Testing of Vascular Stents (Superseded). Migration and disconnection were monitored by digital image correlation for three different overlap lengths (20, 30, and 40 mm). The testing method proposed in this work was efficient to provide a simulated environment to evaluate the influence of gait biomechanics on overlapped endoprosthesis disconnection. Obtained results demonstrated minimal or absence of relevant migration between the endoprostheses, range −0.06 to 0.34 millimeters. The proposed methodology was verified as a valuable tool to investigate the influence of the biomechanical environment that the devices are subjected to on the migration of overlapped endoprostheses. It may become a new alternative to study the preclinical in vitro performance of single endoprosthesis or multiple connected devices with different overlapped regions.
Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons
Authors: Oakley Derek H. , Klickstein Naomi , Commins Caitlin , Chung Mirra , Dujardin Simon , Bennett Rachel E. , Hyman Bradley T. , Frosch Matthew P. 
Published: April 2021

Tau aggregation within neurons is a critical feature of Alzheimer's disease (AD) and related tauopathies. It is believed that soluble pathologic tau species seed the formation of tau aggregates in a prion-like manner and propagate through connected neurons during the progression of disease. Both soluble and aggregated forms of tau are thought to have neurotoxic properties. In addition, different strains of misfolded tau may cause differential neurotoxicity. In this work, we present an accelerated human neuronal model of tau-induced neurotoxicity that incorporates both soluble tau species and tau aggregation. Using patient-derived induced pluripotent stem cell (iPSC) neurons expressing a tau aggregation biosensor, we develop a cell culture system that allows continuous assessment of both induced tau aggregation and neuronal viability at single-cell resolution for periods of >1 week. We show that exogenous tau “seed” uptake, as measured by tau repeat domain (TauRD) reporter aggregation, increases the risk for subsequent neuronal deathin vitro. These results are the first to directly visualize neuronal TauRD aggregation and subsequent cell death in single human iPSC neurons. Specific morphologic strains or patterns of TauRD aggregation are then identified and associated with differing neurotoxicity. Furthermore, we demonstrate that familial AD iPSC neurons expressing the PSEN1 L435F mutation exhibit accelerated TauRD aggregation kinetics and a tau strain propagation bias when compared with control iPSC neurons.SIGNIFICANCE STATEMENTNeuronal intracellular aggregation of the microtubule binding protein tau occurs in Alzheimer's disease and related neurodegenerative tauopathies. Tau aggregates are believed to spread from neuron to neuron via prion-like misfolded tau seeds. Our work develops a human neuronal live-imaging system to visualize seeded tau aggregation and tau-induced neurotoxicity within single neurons. Using an aggregation-sensing tau reporter, we find that neuronal uptake and propagation of tau seeds reduces subsequent survival. In addition, human induced pluripotent stem cell (iPSC) neurons carrying an Alzheimer's disease-causing mutation in presenilin-1 undergo tau seeding more rapidly than control iPSC neurons. However, they do not show subsequent differences in neuronal survival. Finally, specific morphologies of tau aggregates are associated with increased neurotoxicity.
How much is Historical Knowledge Present in Bilingual Dictionaries?
Authors: Valančiauskienė Aušra 
Published: April 2021

During the development of structuralist semantics, there was a strong emphasis on distinguishing encyclopaedic and linguistic dictionaries. In the latter, any reference to encyclopaedic knowledge should be absent or kept to a minimum. Later it was realised that it is impossible to write a dictionary without using any encyclopaedic explanations. Those explanations make a dictionary more attractive, more interesting to read, and therefore more usable. This is particularly important when preparing bilingual dictionaries because it is two languages and two cultures that are being aligned and compared. As lexica related to cognitive fields (physics, medicine, botany, etc.) is incorporated into the nomenclature of modern dictionaries, relevant encyclopaedic information is then added by way of explanation. Accordingly, this article examines, based on analytical and descriptive methods, how historical knowledge is presented in the micro-and partly macro-structures of four dictionaries: The Great Lithuanian-English Dictionary (2006), Lithuanian-Russian Dictionary (2015), The Great Lithuanian-French Dictionary (2012) and Lithuanian-Norwegian Dictionary (2016).
Synthesis and characterization of C60 and C70 acetylacetone monoadducts and study of their photochemical properties for potential application in solar cells
Authors: Duarte-Ruiz Alvaro , Iuele Helena , Torres Sergio Alejandro , Melendez Angie , Velasquez Jose Daniel , Chaur Manuel 
Published: April 2021

We report on the synthesis of C60 and C70 monoadducts at room temperature through the Bingel reaction; employing acetylacetone as ligand; in presence of DBU (1,8-Diazabicyclo [5.4.0] undec-7-ene), carbon tetrabromide (CBr4), and o-dichlorobenzene. Diacetylmethane-[C60-Ih]-fullerene-[5,6] and diacetylmethane-[C70-D5h]-fullerene-[5,6] monoadducts were obtained with yields of 69% and 44%, respectively. The products were purified by column chromatography (CC, on silica gel, using hexane, carbon disulfide, and chloroform as eluents at room temperature) and characterized by Nuclear Magnetic Resonance (1H and 13C), Fourier-Transform Infrared (FT-IR) and UV-Visible spectroscopies, Matrix-assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) Mass spectrometry, Cyclic Voltammetry (CV), and Osteryoung Square Wave Voltammetry (OSWV). Both compounds showed irreversible reduction peaks controlled by diffusion, with LUMO energy levels of -3.09 eV, -3.13 eV for C60, and C70 monoadducts, respectively. These values are comparable with the -3.99 eV of PC61BM. The synthetized adducts were incorporated into inverted-type perovskite solar cells and were used as electron transporting materials (ETM) obtaining power conversion efficiencies (PCE) of 8.5% and 14.0% for the C60 and C70 monoadducts, respectively. When C60 is replaced by a lower symmetrical fullerene such as C70 an improved light absorption in the visible region is observed.
Complement Activation Products in the Urine from Proteinuric Patients
Authors: MORITA YOSHIKI , IKEGUCHI HIROSHI , NAKAMURA JIRO , HOTTA NIGISHI , YUZAWA YUKIO , MATSUO SEIICHI 
Published: April 2021

Abstract.
The presence of plasma proteins in the tubular lumen has variety of adverse effects on the tubular cells. Among various plasma proteins filtered through glomerular barrier, complement has been proven as the possible candidate inducing tubulointerstitial injury. To study the role of intratubular complement activation in proteinuric patients, complement activation products (CAP) at C3 level (iC3b and Bb) and C9 level (membrane attack complex) were measured in both plasma and urine of patients with minimal change nephrotic syndrome (MCNS), focal glomerular sclerosis, IgA nephropathy, membranous nephropathy, and diabetic nephropathy. For evaluation of the effect of metabolic acidosis on the intratubular complement activation, urinary CAP were measured before and after sodium bicarbonate administration in patients with renal insufficiency. The following results were obtained: (1) Patients with focal glomerular sclerosis and diabetic nephropathy showed the highest level of urinary CAP excretion rate (unit/creatinine), while MCNS revealed no increase. (2) Patients with membranous nephropathy showed a unique finding, i.e., isolated increase of membrane attack complex excretion. (3) There was no significant correlation between urine and plasma levels of CAP. (4) Except for MCNS patients, the urinary excretion rate of CAP significantly increased when the level of proteinuria exceeded the nephrotic range, and it was significantly correlated with the serum creatinine level. (5) Urinary CAP excretion rate significantly decreased 2 wk after sodium bicarbonate administration without affecting the level of proteinuria or plasma CAP. These results suggest that the degree of intratubular complement activation correlates with the level of proteinuria, type of glomerular disease, impairment of renal function, and metabolic acidosis.
Nutrition and Outcome on Renal Replacement Therapy of Patients with Chronic Renal Failure Treated by a Supplemented Very Low Protein Diet
Authors: APARICIO MICHEL , CHAUVEAU PHILIPPE , PRÉCIGOUT VALÉRIE DE , BOUCHET JEAN-LOUIS , LASSEUR CATHERINE , COMBE CHRISTIAN 
Published: April 2021

Abstract.
Protein-restricted diets are prescribed in patients with chronic renal failure (CRF) to alleviate uremic symptoms and to slow the progression of CRF. The potential deleterious effects of protein restriction on nutritional status and clinical outcome of patients with CRF have raised concern. In this study, data were collected from 1985 to 1998 on 239 consecutive patients (age 50.2 ± 15.6 yr) with advanced CRF (GFR 13.1 ± 4.8 ml/min) to whom a supplemented very low protein diet (SVLPD) providing 0.3 g protein, 35 kcal, and 5 to 7 mg of inorganic phosphorus per kg per day was administered for a mean duration of 29.6 ± 25.1 mo. The diet was supplemented with essential amino acids and ketoanalogs, calcium carbonate, iron, and multivitamins. During SVLPD, protein intake decreased from 0.85 ± 0.23 to 0.43 ± 0.11 g/kg per d, and body mass index and serum albumin concentration remained unchanged overall. Fourteen patients died during SVLPD; death was unrelated to nutritional parameters. Hemodialysis was initiated after SVLPD in 165 patients at a mean GFR of 5.8 ± 1.5 ml/min. During an average of 54 mo on hemodialysis, mortality was low (2.4% after 1 yr) and correlated to age only, not to nutritional parameters observed at the end of SVLPD. Similar results were obtained in 66 transplanted patients (12 were not dialyzed before transplantation). SVLPD can be safely used in patients with CRF without adverse effects on the clinical and nutritional status of the patients. Due to the preservation of nutritional status and the correction of uremic symptoms, the initiation of dialysis was deferred in these patients. The outcome of patients on renal replacement therapy is not affected by prior treatment with SVLPD during the predialysis phase of CRF.
İnegöl (Bursa) havzasında hava kalitesinin fiziki ortam ile ilişkisi
Authors: İSKAN Semra , KOÇ Telat 
Published: April 2021

Bu çalışma, son yıllarda insan sağlığını etkileyecek boyuta ulaşan İnegöl’ün (Bursa) hava kirliliği sorunlarını araştırıyor. İnegöl havzasında hava kalitesinin bozulmasının neden ve sonuçları bakımından yeterli çalışma olmaması, sürdürülebilir kullanım açısından bilimsel sorun olarak tanımlanmıştır. Sunulan araştırmada, İnegöl yerleşmesinin etkileşim alanı da dikkate alınarak, Kasım- Aralık 2016 ile Ocak- Şubat 2017 kış (soğuk) döneminden hareketle, hava kalitesi özelliklerini belirleyerek, bu durumu şekillendiren fiziki ortam özelliklerinin belirlenmesi amaçlanmıştır. Hava kalitesini incelemek için Çevre ve Şehircilik Bakanlığı’ndan kirletici maddeler olarak belirlenen PM10 ve SO2 verileri alınmış ve havza üzerinde dört farklı yükseltiye(284 m, 316 m, 426 m, 827 m) sıcaklık ölçme istasyonu kurulmuştur. Elde edilen sıcaklık verileriyle, havza üzerinde terselmenin geliştiği tespit edilmiştir. Hava tipine bağlı olarak gelişen bu terselmelerin, topografyanın da etkisiyle daha da güçlendiği sonucuna ulaşılmıştır. İnegöl havzasında, hava kalitesinin şekillenmesinde kaynaktan çıkan kirletici miktarının yanı sıra fiziki ortam özellikleri de belirleyici olmaktadır. Buna ek olarak İnegöl yerleşmesinin, havza tabanına kurulmuş olması, hava kalitesinin düşük olmasına ortam hazırlayan etmen olarak dikkat çekmektedir. Bu nedenle belirlenen sorunun çözümü için öncelikle arazi kullanımı ve planlamasında, fiziki ortamın özelliklerinin dikkate alınmasının gerekliliği ortaya çıkmaktadır.
Assessment of serum ferritin and thyroid hormones level in acute ischemic stroke and their association with hemorrhagic conversion
Authors: Giri Richa , Ahamed Faim , Agarwal Saurabh , Kumar Lalit 
Published: April 2021

Background: Acute ischemic stroke is a significant cause of mortality and the leading cause of long-term disability in the United States. Collective evidence suggests that low T3 levels and serum ferritin levels instantly following acute ischemic stroke are connected with greater stroke sternness, higher death rates, and poor functional outcomes. The aim of the study was to assess the serum ferritin and thyroid hormones level in acute ischemic stroke their association with hemorrhagic conversion.Methods: In this observational study, 60 acute ischemic stroke patients aged ≥ 18 years of both gender who were reported with focal neurological deficit lasting greater than 24 hours were included. Clinical severity of stroke was assessed at admission and on the 7th day using Glasgow coma scale (G.C.S.), serum ferritin level, and thyroid hormones level were measured at admission and on the 7th day in all these subjects.Results: Overall mean age of patients was 56.28±11.45 years with a range of 29-87 years; 61.7% were male patients. Ischemic stroke was found in 55 (91.7%) patients, while 5 (8.3%) patients showed hemorrhagic conversion. Serum Ferritin and T3 level shows a significant association with G.C.S. score (p<0.05). Hemorrhagic Conversion patients were significantly greater in-hospital stay than the acute ischemic stroke group (p<0.05).Conclusions: In our study, it was observed that after acute ischemic stroke high ferritin level and low T3 is associated with worse neurological outcome and linked to the poorer results at hospital discharge.
What Hospitality is Not
Authors: Oguanobi Hembadoon Iyortyer 
Published: April 2021

A poem describing concern about what hospitality is not about, that is, how migration to a new place eventually changes an individual. It is about how a person will reinvent themself. It is about how new taste and new ways of seeing are (re)discovered. It is about how one will familiarize themself with new beats and new rhythms aimed at repressing the memory of the ancient home.
A produção da subalternidade sob a ótica pós-colonial (e decolonial)
Authors: Ribeiro Adelia Miglievich , Prazeres Lílian Lima Gonçalves dos 
Published: April 2021

Buscamos apresentar perspectivas teóricas que compõem ou influenciaram os chamados estudos pós-coloniais e decoloniais. Para tanto, iniciamos por Foucault que possibilitou a percepção do poder entremeado às microrelações, com ênfase ao disciplinamento dos corpos e à criação das normas subliminares de conduta. Transitamos em seguida por Derrida e Hall a fim de marcar as influências pós-moderna e pós-estruturalista na descolonização epistemológica. Ao trazer o debate para as vozes silenciadas pela diferença colonial - antítese da différance - observamos o benefício da expressão entre-lugar do brasileiro Santiago e do indiano Bhabha, como possível sinônimo de hibridismo, trânsito, fronteira, a partir das quais identidades são deslocadas e reinventadas. Acrescemos os latino-americanos do grupo modernidade-colonialidade, Quijano e Maldonado-Torres a fim de expor os tipos de colonialidade existentes e a necessidade de pensar epistemologias próprias que possam superá-los, a exemplo do feminismo decolonial de Spivak (2010), Lerma (2014) e Lugones (2011). Concluímos que há relevância nas inquietações acerca das persistentes colonialidades do poder, do saber e do ser, e chamamos atenção para a necessidade da desconstrução como método de compreensão das realidades e dos discursos sobre as realidades com o intuito de conceber uma crítica intelectual mais efetiva à produção e reprodução das subalternidades.
As mulheres no campo político
Authors: Zeytounlian Lauren , Caminhas Lorena Rubia Pereira , Vasco Marcela , Negretti Natália , Ponte Vanessa 
Published: April 2021

Neste ensaio investigamos os discursos midiáticos acerca de gênero difundidos em três distintos momentos da política contemporânea brasileira: a eleição e posse da presidenta Dilma Rousseff; o processo de impeachmentinstaurado em dezembro de 2015 e finalizado em agosto de 2016; e o estabelecimento do governo interino de Michel Temer. A análise foi realizada a partir de matérias jornalísticas veiculadas em jornais, revistas e portais onlinedo país no período dos acontecimentos (predominantemente textos da primeira metade de 2016). Complementarmente, analisamos os comentários de internautas relacionados às reportagens. O material estudado revelou que os principais enunciados expressavam uma retomada do espaço doméstico como lugar da mulher e enfatizavam uma incapacidade das mulheres para assumir cargos de relevo na vida pública, constituindo-se como argumentos mobilizados para legitimar o impedimento de Dilma.
Excision and Reconstruction of Alveolar Rhabdomyosarcoma Involving the Achilles Tendon in a Pediatric Patient
Authors: Koressel Joseph , Stein Matthew , Serra López Viviana M. , Bhatti Tricia R. , Arkader Alexandre 
Published: April 2021

Case:
We describe a case of a 9-year-old boy who presented with a left calf mass consistent with alveolar rhabdomyosarcoma involving the Achilles tendon. The patient underwent radical resection of the Achilles tendon and Achilles tendon allograft reconstruction. At 2.5-year follow-up, the child had full ankle range of motion and strength and no signs of disease.

Conclusions:
Radical resection of Achilles tendon in the setting of malignancy and reconstruction with allograft is a rare procedure that has not been previously described in the pediatric population. Orthopaedic oncologists can consider this option for the rare malignancies involving the Achilles tendon.
Hydraulic Fracture Characterization Using Rapid Simulation
Authors: Moridis Nefeli , Lee John , Lam Duc , Schultz Christie , Wardlow Wade 
Published: April 2021

Abstract
The purpose of this paper is to present a technique to estimate hydraulic fracture (HF) length, fracture conductivity, and fracture efficiency using simple and rapid but rigorous reservoir simulation matching of historical production, and where available, pressure. The methodology is particularly appropriate for analysis of horizontal wells with multiple fractures in tight unconventional or unconventional resource plays. In our discussion, we also analyze the differences between the results from decline curve analysis (DCA) approach and the Science Based Forecasting (SBF) results that this work proposes. When we characterize fracture properties with SBF, we can do a better job of forecasting than if we randomly combine fracture properties and reservoir permeability together in a decline-curve trend. The forecasts are significantly different with SBF, therefore fracture characterization plays an important role and SBF uses this characterization to produce different (and better) forecasts.
Turning Produced Water into an Asset: A Delaware Basin Case History
Authors: Aro Dustin , Fowler Steven 
Published: April 2021

Abstract
The Delaware Basin encompasses 6.4 million acres throughout Southeastern New Mexico and West Texas. With large players such as ExxonMobil, Shell or Oxy typically grabbing headlines, it's easy to forget the multitude of smaller public and private E&P operators who exist in and around the acreage positions of the aforementioned companies. Regardless of the size of the acreage holding, a consistent theme is that a typical horizontal well drilled and completed (D&C) will yield water cuts of 60-90% at any given period in its productive lifespan.
Saltwater production, handling and disposal (SWD) is a drag on lease operating expenses (LOE). SWD costs via trucking, pipeline, or on-lease SWD wells can range between $0.50-$3.00/bbl. As existing infrastructure is exhausted, water handling costs have been projected to rise to over $5.00/bbl. Additionally, restricted access to SWD could cause production curtailments and thus impacting operators beyond direct LOE.1
Well completion operations are impacted by freshwater procurement costs starting around $0.75/bbl. Regardless of final frac design, water consumption during fracturing operations typically exceeds 500,000 bbls or $375,000 per well. Significant value exists for recycling produced water via an on-lease pit and utilizing it for future frac operations. The produced water turns into an asset if the operator can efficiently manage to substitute higher and higher percentages of freshwater with produced water.
Many smaller operators (defined as less than 50,000 acres) may view produced water recycling as an operation best left to large E&P's with their massive capital budgets and contiguous acreage. Fortunately, even a 5 well, section development plan can yield returns from an on-lease produced water recycling program.