bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entre os Direitos Culturais e a Ecologia Humana / Between Cultural Rights And Human Ecology
Authors: Souza Larissa Fernanda De Alencar , Santos Juracy Marques dos 
Published: November 2021

Resumo: O trabalho em epígrafe visa discutir as relações que se estendem entre os direitos culturais e a Ecologia Humana. De forma bibliográfica e analítica, apresentamos o percurso que leva da definição de cultura aos direitos culturais. Dentro dessa discussão, analisamos a Declaração Universal dos Direitos Humanos como primeiro passo de promoção dos direitos culturais, importante para aprofundamento da discussão e extensão no devido debate. Num segundo momento, destacam-se os direitos culturais e políticas públicas culturais no Brasil, apresentando um histórico que passa pela constituição a aplicação de direitos culturais por meio das políticas públicas desenvolvidas. Por conseguinte, se discute a Ecologia humana em seu âmbito de Ecologia Cultural, em favor de analisar a importância de direitos culturais dentro desta matéria. Com base na Declaração de Friburgo, documento internacional que versa sobre a aplicação de direitos culturais, essa análise se dará através de 3 aspectos: a autodeterminação dos povos, o direito a identidade e patrimônio cultural, e os princípios de governança democrática. Assim, compreendemos que a ecologia humana cultural e os direitos culturais possuem uma relação mútua e interdependente para alcançar seus objetivos. Palavras-chave: Ecologia Cultural; Direitos Humanos; Autodeterminação dos Povos; Governança Democrática. Abstract: The above work aims to discuss the relationships that extend between cultural rights and Human Ecology. In a bibliographical and analytical way, we present the path that leads from the definition of culture to cultural rights. Within this discussion, we analyze the Universal Declaration of Human Rights as a first step in promoting cultural rights, which is important for deepening the discussion and extending the due debate. In a second moment, cultural rights and cultural public policies in Brazil stand out, presenting a history that goes through the constitution and application of cultural rights through the developed public policies. Therefore, human ecology is discussed in its scope of cultural ecology, in favor of analyzing the importance of cultural rights within this matter. Based on the Friborg Declaration, an international document that deals with the application of cultural rights, this analysis will be carried out through 3 aspects: the self-determination of peoples, the right to identity and cultural heritage, and the principles of democratic governance. Thus, we understand that cultural human ecology and cultural rights have a mutual and interdependent relationship to achieve their goals. Keywords: Cultural Ecology; Human Rights; Self-determination of People; Democratic Governance.
Utilização de modelos didáticos no ensino da anatomia humana da educação básica ao ensino superior / Use of didactic models in teaching human anatomy from basic education to higher education
Authors: Silva Tatiano Gomes da , Silva Taciane Laiane Gomes da , Silva Thaylane Gomes da 
Published: November 2021

Resumo: Possuidora de um sistema educacional extremamente tecnicista, a educação brasileira ao longo dos anos necessitou de significativa reformulação de metodologias que facilitassem a aprendizagem dos estudantes. Nesse quesito, os estudos sobre novos métodos e mecanismos de ensino foram fomentados para a evolução significativa de conceitos. Assim, verificou-se a necessidade de produção e uso de modelos didáticos no ensino, especialmente na anatomia humana, por apresentar uma certa complexidade de termos que na maioria das vezes dificultam a apreensão dos estudantes. Nesse aspecto, o presente artigo tem o objetivo de fazer uma análise sistemática da utilização de modelos didáticos na abordagem da anatomia humana na educação básica e superior, visando perceber o quanto é importante o uso de tais instrumentos pedagógicos para o ensino e aprendizagem da anatomia humana. Assim, a utilização de modelos didáticos no ensino da anatomia humana torna-se uma verdadeira ferramenta que facilita a aprendizagem de forma mais dinâmica. Palavras-chave: Anatomia Humana. Modelos Didáticos. Metodologias Ativas em Anatomia. EnsinoAbstract: Possessing an extremely technicist educational system, Brazilian education over the years required a significant reformulation of methodologies that facilitated student learning. In this regard, studies on new teaching methods and mechanisms were encouraged for the significant evolution of concepts. Thus, there was a need for the production and use of didactic models in teaching, especially in human anatomy, as they present a certain complexity of terms that most often make it difficult for students to understand. In this aspect, this article aims to make a systematic analysis of the use of didactic models in the approach of human anatomy in basic and higher education, aiming to realize how important the use of such pedagogical tools is for the teaching and learning of human anatomy. Thus, the use of didactic models in teaching human anatomy becomes a real tool that facilitates learning in a more dynamic way. Keywords: Human Anatomy. Didactic Models. Active Methodologies in Anatomy. Teaching.
Anais do VI Congresso de Saúde da Mulher do Cariri - SAÚDE MENTAL / Proceedings of the VI Cariri Women's Health Congress - MENTAL HEALTH
Authors: Brayner Patrícia Maria De Albuquerque , Oliveira Tainã Brito Siebra de , Feitosa Neto José De Araújo , Lima Brena Suianne Pereira , Macedo Lorena Magalhães de 
Published: November 2021

O Congresso de Saúde da Mulher do Cariri (CONSMUC) é organizado anualmente pelo Programa de Atenção à Gestante (ProGest), projeto de extensão vinculado à Faculdade de Medicina da Universidade Federal do Cariri, sob orientação da professora efetiva do curso de medicina Patrícia Maria de Albuquerque Brayner. O congresso aborda temáticas importantes na área de Saúde da Mulher. Esse ano, em sua VI edição, foi realizado nos dias 1 a 3 de Outubro de 2021 em versão on- line, abordando como temática principal a “Saúde Mental”. Palavras-Chave: Saúde da Mulher; Congresso; Saúde MentalAbstract: The Cariri Women's Health Congress (CONSMUC) is organized annually by the Pregnancy Care Program (ProGest), an extension project linked to the Faculty of Medicine of the Federal University of Cariri, under the guidance of the effective professor of the medicine course, Patrícia Maria de Albuquerque Brayner. The congress addresses important themes in the area of Women's Health. This year, in its VI edition, it was held from October 1st to 3rd, 2021 in an online version, addressing as the main theme “Mental Health”.Keywords: Women´s Health; Congress; Mental Health
Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen
Authors: Kellner Christian , Lutz Sebastian , Oberg Hans-Heinrich , Wesch Daniela , Otte Anna , Diemer Katarina J. , Wilcken Hauke , Bauerschlag Dirk , Glüer Claus-Christian , Wichmann Christian , Kabelitz Dieter , Leusen Jeanette H. W. , Klausz Katja , Humpe Andreas , Gramatzki Martin , Peipp Matthias 
Published: October 2021

Abstract
Natural killer group 2 member D (NKG2D) plays an important role in the regulation of natural killer (NK) cell cytotoxicity in cancer immune surveillance. With the aim of redirecting NK cell cytotoxicity against tumors, the NKG2D ligand UL-16 binding protein 2 (ULBP2) was fused to a single-chain fragment variable (scFv) targeting the human epidermal growth factor receptor 2 (HER2). The resulting bispecific immunoligand ULBP2:HER2-scFv triggered NK cell-mediated killing of HER2-positive breast cancer cells in an antigen-dependent manner and required concomitant interaction with NKG2D and HER2 as revealed in antigen blocking experiments. The immunoligand induced tumor cell lysis dose-dependently and was effective at nanomolar concentrations. Of note, ULBP2:HER2-scFv sensitized tumor cells for antibody-dependent cell-mediated cytotoxicity (ADCC). In particular, the immunoligand enhanced ADCC by cetuximab, a therapeutic antibody targeting the epidermal growth factor receptor (EGFR) synergistically. No significant improvements were obtained by combining cetuximab and anti-HER2 antibody trastuzumab. In conclusion, dual-dual targeting by combining IgG1 antibodies with antibody constructs targeting another tumor associated antigen and engaging NKG2D as a second NK cell trigger molecule may be promising. Thus, the immunoligand ULBP2:HER2-scFv may represent an attractive biological molecule to promote NK cell cytotoxicity against tumors and to boost ADCC.
Maternal oxytocin administration modulates gene expression in the brains of perinatal mice
Authors: Hsieh Frances F. , Korsunsky Ilya , Shih Andrew J. , Moss Matthew A. , Chatterjee Prodyot K. , Deshpande Jaai , Xue Xiangying , Madankumar Swati , Kumar Gopal , Rochelson Burton , Metz Christine N. 
Published: October 2021

Abstract

Objectives
Oxytocin (OXT) is widely used to facilitate labor. However, little is known about the effects of perinatal OXT exposure on the developing brain. We investigated the effects of maternal OXT administration on gene expression in perinatal mouse brains.

Methods
Pregnant C57BL/6 mice were treated with saline or OXT at term (n=6–7/group). Dams and pups were euthanized on gestational day (GD) 18.5 after delivery by C-section. Another set of dams was treated with saline or OXT (n=6–7/group) and allowed to deliver naturally; pups were euthanized on postnatal day 9 (PND9). Perinatal/neonatal brain gene expression was determined using Illumina BeadChip Arrays and real time quantitative PCR. Differential gene expression analyses were performed. In addition, the effect of OXT on neurite outgrowth was assessed using PC12 cells.

Results
Distinct and sex-specific gene expression patterns were identified in offspring brains following maternal OXT administration at term. The microarray data showed that female GD18.5 brains exhibited more differential changes in gene expression compared to male GD18.5 brains. Specifically, Cnot4 and Frmd4a were significantly reduced by OXT exposure in male and female GD18.5 brains, whereas Mtap1b, Srsf11, and Syn2 were significantly reduced only in female GD18.5 brains. No significant microarray differences were observed in PND9 brains. By quantitative PCR, OXT exposure reduced Oxtr expression in female and male brains on GD18.5 and PND9, respectively. PC12 cell differentiation assays revealed that OXT induced neurite outgrowth.

Conclusions
Prenatal OXT exposure induces sex-specific differential regulation of several nervous system-related genes and pathways with important neural functions in perinatal brains.
Enhanced S100B expression in T and B lymphocytes in spontaneous preterm birth and preeclampsia
Authors: Busse Mandy , Scharm Markus , Oettel Anika , Redlich Anke , Costa Serban-Dan , Zenclussen Ana Claudia 
Published: October 2021

Abstract

Objectives
S100B belongs to the family of danger signaling proteins. It is mainly expressed by glial-specific cells in the brain. However, S100B was also detected in other cell likewise immune cells. This molecule was suggested as biomarker for inflammation and fetal brain damage in spontaneous preterm birth (sPTB), preeclampsia (PE) and HELLP (hemolysis, elevated liver enzymes, and low platelet count).

Methods
The aim of our study was to determine the concentration of S100B in maternal and cord blood (CB) plasma and placenta supernatant as well as the expression of S100B in maternal and CB CD4+ T cells and CD19+ B cells in sPTB and patients delivering following PE/HELLP diagnosis compared to women delivering at term (TD). The S100B expression was further related to the birth weight in our study cohort.

Results
S100B concentration was enhanced in maternal and CB plasma of sPTB and PE/HELLP patients and positively correlated with interleukin-6 (IL-6) levels. Increased S100B was also confirmed in CB of small-for-gestational-age (SGA) infants. S100B expression in maternal blood was elevated in CD4+ T cells of PE/HELLP patients and patients who gave birth to SGA newborns as well as in CD19+ B cells of sPTB and PE/HELLP patients and patients with SGA babies. In CB, the expression of S100B was increased in CD19+ B cells of sPTB, PE/HELLP and SGA babies.

Conclusions
Our results support the hypothesis that S100B expression is enhanced in inflammatory events associated with preterm birth and that S100B expression in immune cells is a relevant marker for inflammation during pregnancy complications.
Dressed emitters as impurities
Authors: Leonforte Luca , Valenti Davide , Spagnolo Bernardo , Carollo Angelo , Ciccarello Francesco 
Published: October 2021

AbstractDressed states forming when quantum emitters or atoms couple to a photonic bath underpin a number of phenomena and applications, in particular nonradiating effective interactions occurring within photonic bandgaps. Here, we present a compact formulation of the resolvent-based theory for calculating atom-photon dressed states built on the idea that the atom behaves as an effective impurity. This establishes an explicit connection with the standard impurity problem in condensed matter. Moreover, it allows us to formulate and settle – independently of the bath Hamiltonian – a number of properties previously known only for specific models or not entirely formalized. The framework is next extended to the case of more than one emitter, which is used to derive a general expression of dissipationless effective Hamiltonians explicitly featuring the overlap of single-emitter dressed bound states.
Dorsomedial Striatal Activity Tracks Completion of Behavioral Sequences in Rats
Authors: Vandaele Youna , Ottenheimer David J. , Janak Patricia H. 
Published: November 2021

AbstractFor proper execution of goal-directed behaviors, individuals require both a general representation of the goal and an ability to monitor their own progress toward that goal. Here, we examine how dorsomedial striatum (DMS), a region pivotal for forming associations among stimuli, actions, and outcomes, encodes the execution of goal-directed action sequences that require self-monitoring of behavior. We trained rats to complete a sequence of at least five consecutive lever presses (without visiting the reward port) to obtain a reward and recorded the activity of individual cells in DMS while rats performed the task. We found that the pattern of DMS activity gradually changed during the execution of the sequence, permitting accurate decoding of sequence progress from neural activity at a population level. Moreover, this sequence-related activity was blunted on trials where rats did not complete a sufficient number of presses. Overall, these data suggest a link between DMS activity and the execution of behavioral sequences that require monitoring of ongoing behavior.
Functional preparedness of women of the first period of mature age of different somatotypes
Authors: Miroshnichenko Viacheslav M. , Furman Yuriy M. , Bohuslavska Viktoriia Yu. , Brezdeniuk Oleksandra Yu. , Salnykova Svitlana V. , Shvets Oksana P. , Boiko Maryna O. 
Published: October 2021

Background and Study Aim. It is believed that the somatotype is a predictor of indicators of functional readiness. There are significant differences in the aerobic performance of the body for people of different somatotypes among students girls and men. Features of manifestation of anaerobic possibilities of an organism at persons of various somatotypes from 7 to 30 years old are described. We can assume that women of the first adulthood period of different somatotypes, indicators of functional readiness are manifested in different ways. The aim of the study was to identify the features of aerobic, anaerobic lactate and anaerobic alactate productivity of women of the first period of mature age of different somatotypes.
Material and Methods. The study involved 210 females 25-35 years old. Somatotype was determined in all subjects. Functional readiness was determined by indicators of anaerobic lactatic productivity, anaerobic alactatic productivity and aerobic productivity of the organism. The power of aerobic energy supply processes was investigated by VO2max. To determine the VO2max used cycling ergometric version of the PWC 170 test. The subjects was performed a stepwise increasing load on the ergometer to determine the TAM. At the end of each stage, heart rate was recorded. The TAM level corresponded to the inflection point on the heart rate growth chart. The capacity of anaerobic lactate processes of energy supply was investigated by indicator of the maximum quantity of mechanical work for 1 minute (MQMK). The subjects performed a bicycle ergometric load duration 1 min with a power of 225 W with a maximum pedaling frequency. The power of anaerobic lactate processes of energy supply was determined by the Wingate anaerobic test WAnT 30. The power of anaerobic alactate processes of energy supply was determined by the test WAnT 10. Statistical processing was performed using the program STATISTICA 13.
Results. According to absolute indicators (WAnT10. WAnT30. MQMK, TAM, VO2max) the advantage of representatives of endomorphic-mesomorphic somatotype was established. According to relative indicators of aerobic productivity (TAM, VO2max) representatives of the ectomorphic and balanced somatotype predominate.
Conclusions. High values of absolute indicators of functional readiness are associated with high values ​​of body mass in combination with a high percentage of muscle for women of different somatotypes. Accordingly, for representatives of somatotypes with lower body mass are characterized by lower absolute values ​​of all indicators of functional fitness. The relative indicators of aerobic productivity are dominated by representatives of somatotypes, which are characterized by lower body mass.
The level of physical activity of university students in Slovakia during COVID - 19 pandemic
Authors: Líška Dávid , Barcalová Miroslava , Liptáková Erika , Jančoková Ľudmila , Vojtaško Ľuboš , Gurín Daniel 
Published: October 2021

Background and Study Aim. COVID-19 coronavirus pandemic has affected several areas of human and public life. The implementation of the restrictions affects free movement, leading to limited physical activity (PA) level. The main aim of the study was to determine the level of PA of university students in Slovakia during COVID–19 pandemics.
Material and Methods. The sample consisted of 3128 university students. Data was obtained from students from three universities with different specializations. A questionnaire about lifestyle with questions about physical activity was used. The questionnaire was distributed using online communication systems of universities. The online questionnaire was answered by 3128 students.
Results. Analyzed data were obtained from 3128 students. The results indicate that 38% of all students exercise 3-4 times per week, while 41% exercise 1-2 times per week, and 21% do not exercise at all, or exercise 1-2 times per month. Found weak positive correlation (r=0,337) was between the exercise frequency and perception of well-being, and a very weak positive correlation (r=0,187) between the exercise frequency and stress intensity. A moderate positive correlation was found between the perception of health and life energy (r=0,579). A moderate positive correlation was observed between the perception of health and physical strength (r=0,579).
Conclusions. COVID-19 restrictions have been associated with the reduction of physical activity of the students. To avoid the negative effects of a sedentary lifestyle, it is necessary to promote activity among university students.
Results of organ-preserving treatment of breast cancer using intraoperative radial therapy
Authors: Chumachenko I. S. , Murashko R. A. , Keshabyan A. A. , Krivorotko P. V. , Novikov S. N. 
Published: October 2021

Objective: to compare the immediate and long-term outcomes of patients with early breast cancer treated with intraoperative radial therapy depending on the biological subtype of breast cancer.Materials and methods. We prospectively evaluated number of recurrences, cosmetic effect and early treatment results of 104 patients with early breast cancer aged 66.72 ± 0.68 years old. The mean follow-up period was 36 months. The mean dose on the surface of applicator was 17.8 Gy, on the depth 0.5 cm – 8.8 Gy, on the depth 1.0 cm – 5 Gy. The mean time of radiation was 22.15 min ± 28.09 sec.Results. The local recurrence was in 3 patients. The first patient had triple negative breast cancer subtype, the second patient had luminal B HER2+, and the third one had luminal B HER2– subtype. Relapses occurred in 7, 14 and 20 months after the end of treatment respectively. The recurrence rate in patients with luminal B biological subtype was 10.71 %; in patients with triple negative subtype was 20 %. All recurrences were found in the area of the postoperative scar.Conclusion. The obtained results question the rationale for the use of the demonstrated method in patients with luminal B and triple negative molecular subtypes of tumors.
Descriptive characteristics of gynecological malignant neoplasms
Authors: Rumyantseva A. V. , Bannikova M. V. , Azizova T. V. 
Published: October 2021

Background. Gynecological malignant neoplasms (GMN) are the leading disease group among female cancers.Objective: to characterize GMN in females occupationally exposed to ionizing radiation over prolonged periods.Materials and methods. The cohort considered in the study included females (n = 5689) who had been hired at the Mayak Production Association in the period between 1948 and 1982. All these females were exposed to ionizing radiation over prolonged periods during their employment. They were followed up until 31.12.2018. Two groups of females were identified in the study cohort: the one with a verified GMN (the main group) and another one free of GMN (the control group). The occupational and reproductive characteristics were analyzed for the identified groups of females, and associations of GMN with various risk factors were assessed.Results. Among GMN the uterine corpus cancer had the top position. In 70 % of the females GMN were diagnosed during a menopausal period. The females of the main group demonstrated significantly higher frequency of underlying pre-malignant conditions (endometriosis, uterine myoma, endometrial hyperplastic processes, ovarian epidermoids, menopausal bleedings) compared to the control group.Conclusion. Studies of GMN in females occupationally exposed to ionizing radiation over prolonged periods for sure are of a certain scientific and practical interest. The findings can provide the basis for specialized cancer care for employees of the nuclear industry.