bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived loneliness and the role of cultural and intergenerational belonging: the case of Portuguese first-generation immigrants in Luxembourg
Authors: Albert Isabelle 
Published: April 2021

AbstractThe risk of loneliness for migrants, particularly in older age, has been documented across multiple studies. Migration is a life-changing transition. While often retaining links to their country of origin, an important developmental task for migrants is the establishment of bonds in the receiving country. Drawing on recent studies, I will explore the role of cultural and intergenerational belonging in order to identify both protective and risk factors regarding loneliness in middle and older age in a sample of first-generation immigrants from Portugal living in Luxembourg. The sample comprises N = 131 participants (51.9% female) between the ages of 41 and 80 (M = 56.08; SD = 7.80) who have on average spent M = 31.71 years (SD = 8.81) in Luxembourg and raised children in Luxembourg. They took part in the IRMA project (‘Intergenerational Relations in the Light of Migration and Ageing’) which was funded by the Fonds National de la Recherche Luxembourg. A standardised questionnaire assessed socio-demographic data, aspects of cultural belonging (i.e. cultural attachment to both countries, bicultural identity orientation, acculturative stress), intergenerational belonging (i.e. family cohesion, family conflict, perceived intergenerational value consensus) and perceived loneliness. Results showed that while cultural and intergenerational belonging were protective factors, the strongest predictors for participants’ perceived loneliness were cultural identity conflict and, even more so, intergenerational conflict. Our findings suggest that establishing roots and bonds in the host country is a protective factor against loneliness, whereas the feeling of not fitting in is a strong risk factor.
Perceptions of Challenges Affecting Research Ethics Committees’ Members at Medical and Health Science Colleges in Omani and Jordanian Universities
Authors: Al Omari Omar , Khalaf Atika , Al Delaimy Wael , Al Qadire Mohammad , Khatatbeh Moawiah M. , Thultheen Imad 
Published: April 2021

AbstractIn recent years there has been an increase in research conducted in the Middle East, with a corresponding increase in the challenges faced by members of the Research Ethics Committees (RECs). This study compares the structures of Omani and Jordanian RECs and investigates the perceptions of the challenges affecting the work of the REC members in Oman and Jordan. A convenience sample of 34 Omani and 66 Jordanian participants from 21 universities was recruited in this cross-sectional study. Almost 70% disagreed that the members of RECs are unqualified, providing comments without justification; half believed that members have limited experience in research, and almost three-quarters that they have different opinions regarding some ethical issues. No significant differences were found between Omani and Jordanian REC members regarding their perception of the challenges, except for the perception that reviewing proposals is a time-consuming task (p = 0.048) and that multi-REC centres are less available (p = 0.026). The regression model showed that there were significantly more male members of Jordanian RECs, and that Jordanian members were less likely to receive formal training. In conclusion, the current structure of RECs and the challenges faced by members need to be re-evaluated by decision makers to improve the overall quality of research activities, and to ensure that current REC members’ practices adhere to international standards.
Commercially available garden products as important sources of antibiotic resistance genes—a survey
Authors: Cira Marisol , Echeverria-Palencia Cristina M. , Callejas Ileana , Jimenez Karina , Herrera Rafael , Hung Wei-Cheng , Colima Nicolas , Schmidt Amanda , Jay Jennifer A. 
Published: April 2021

AbstractThe dissemination of antibiotic resistance genes (ARGs) in the environment contributes to the global rise in antibiotic resistant infections. Therefore, it is of importance to further research the exposure pathways of these emerging contaminants to humans. This study explores commercially available garden products containing animal manure as a source of ARGs in a survey of 34 garden products, 3 recently landscaped soils, and 5 native soils. DNA was extracted from these soils and quantified for 5 ARGs, intI1, and 16S rRNA. This study found that both absolute and relative gene abundances in garden products ranged from approximately two to greater than four orders of magnitude higher than those observed in native soils. Garden products with Organic Materials Review Institute (OMRI) certification did not have significantly different ARG abundances. Results here indicate that garden products are important sources of ARGs to gardens, lawns, and parks.
Graphical abstract
Temperature-Dependent Configurational Entropy Calculations for Refractory High-Entropy Alloys
Authors: Nataraj Chiraag M , van de Walle Axel , Samanta Amit 
Published: April 2021

AbstractThe cluster expansion formalism for alloys is used to construct surrogate models for three refractory high-entropy alloys (NbTiVZr, HfNbTaTiZr, and AlHfNbTaTiZr). These cluster expansion models are then used along with Monte Carlo methods and thermodynamic integration to calculate the configurational entropy of these refractory high-entropy alloys as a function of temperature. Many solid solution alloy design guidelines are based on the ideal entropy of mixing, which increases monotonically with $$N$$
N
, the number of elements in the alloy. However, our results show that at low temperatures, the configurational entropy of these materials is largely independent of $$N$$
N
, and the assumption described above only holds in the high-temperature limit. This suggests that alloy design guidelines based on the ideal entropy of mixing require further examination.
Clinical profile and evolution of patients with juvenile-onset Behçet’s syndrome over a 25-year period: insights from the AIDA network
Authors: Sota Jurgen , Rigante Donato , Lopalco Giuseppe , Emmi Giacomo , Gentileschi Stefano , Gaggiano Carla , Ciarcia Luisa , Berlengiero Virginia , Mourabi Mariam , Ricco Nicola , Barneschi Sara , Mattioli Irene , Tosi Gian Marco , Frediani Bruno , Tarsia Maria , di Scala Gerardo , Vitale Antonio , Iannone Florenzo , Fabiani Claudia , Cantarini Luca 
Published: April 2021

AbstractBehçet’s syndrome (BS) represents an understudied topic in pediatrics: the main aims of our study were to characterize demographic and clinical features of a cohort of BS patients with juvenile-onset managed in three tertiary referral centers in Italy, evaluate their evolution in the long-term, and detect any potential differences with BS patients having an adult-onset. Medical records of 64 juvenile-onset and 332 adult-onset BS followed-up over a 2-year period were retrospectively analyzed and compared. Mean age ± SD of first symptom-appearance was 10.92 ± 4.34 years with a female-to-male ratio of 1.06:1. Mucocutaneous signs were the most frequent initial manifestations, followed by uveitis. Throughout the disease course, genital aphthae (76.56%) and pseudofolliculitis (40.63%) prevailed among the mucocutaneous signs, while major organ involvement was represented by gastrointestinal and ocular involvement (43.75 and 34.38%, respectively). No significant differences emerged for both mucocutaneous signs and specific major organ involvement between juvenile-onset and adult BS patients. After excluding nonspecific abdominal pain, juvenile-onset BS patients were less frequently characterized by the development of major organ involvement (p = 0.027). Logistic regression detected the juvenile-onset as a variable associated with reduced risk of long-term major organ involvement (OR 0.495 [0.263–0.932],p = 0.029). In our cohort, juvenile-onset BS resembled the clinical spectrum of adult-onset patients. Pediatric patients with a full-blown disease at onset showed a more frequent mucocutaneous involvement. In addition, patients with juvenile-onset seemed to develop less frequently major organ involvement and had an overall less severe disease course.
Coping strategies in active and inactive men with prostate cancer: a qualitative study
Authors: Langelier David Michael , Jackson Colleen , Bridel William , Grant Christopher , Culos-Reed S. Nicole 
Published: April 2021

Abstract
Purpose
Prostate cancer can result in a shift in the way men perceive their masculinity. Despite the interest in exercise as a treatment strategy to address masculinity concerns, there is insufficient information about how perceptions may differ in active and inactive men. The aim of this study was to explore how exercise might influence self-perceptions of masculinity in men across the exercise continuum (from active to inactive) and in men receiving different forms of treatment for their prostate cancer, including androgen deprivation therapy.

Methods
Individual, semi-structured interviews were conducted with 15 men. Ten men met aerobic and/or resistance guidelines and were considered active, while five men, considered inactive, reached neither guideline. This study used a grounded theory approach to data analysis, examining masculinity issues in active men and compared them to inactive men.

Results
Redefining masculinity emerged as an overarching theme. Subthemes were the various coping strategies men used to redefining masculinity and directly related to their exercise habits. Coping subthemes included re-establishing control, tapping into competition, remaining socially connected, rationalization, and acceptance.

Conclusions
In the active men, dominant coping strategies achieved from exercise included control through active participation, acceptance, competition, and leadership. In inactive men, control was observed with knowledge-seeking behaviors, rationalization, and acceptance.

Implications for Cancer Survivors
A tailored approach to exercise counseling based upon specific masculine traits and motivations could lead to improved exercise engagement.
Digital Technologies for Schizophrenia Management: A Descriptive Review
Authors: Chivilgina Olga , Elger Bernice S. , Jotterand Fabrice 
Published: April 2021

Abstract
While the implementation of digital technology in psychiatry appears promising, there is an urgent need to address the implications of the absence of ethical design in the early development of such technologies. Some authors have noted the gap between technology development and ethical analysis and have called for an upstream examination of the ethical issues raised by digital technologies. In this paper, we address this suggestion, particularly in relation to digital healthcare technologies for patients with schizophrenia spectrum disorders. The introduction of digital technologies in psychiatry offers a broad spectrum of diagnostic and treatment options tailored to the health needs and goals of patients’ care. These technologies include wearable devices, smartphone applications for high-immersive virtual realities, smart homes, telepsychiatry and messaging systems for patients in rural areas. The availability of these technologies could increase access to mental health services and improve the diagnostics of mental disorders.

Additional Instruction Abstract
In this descriptive review, we systematize ethical concerns about digital technologies for mental health with a particular focus on individuals suffering from schizophrenia. There are many unsolved dilemmas and conflicts of interest in the implementation of these technologies, such as (1) the lack of evidence on efficacy and impact on self-perception; (2) the lack of clear standards for the safety of their daily implementation; (3) unclear roles of technology and a shift in the responsibilities of all parties; (4) no guarantee of data confidentiality; and (5) the lack of a user-centered design that meets the particular needs of patients with schizophrenia. mHealth can improve care in psychiatry and make mental healthcare services more efficient and personalized while destigmatizing mental health disorders. To ensure that these technologies will benefit people with mental health disorders, we need to heighten sensitivity to ethical issues among mental healthcare specialists, health policy makers, software developers, patients themselves and their proxies. Additionally, we need to develop frameworks for furthering sustainable development in the digital technologies industry and for the responsible usage of such technologies for patients with schizophrenia in the clinical setting. We suggest that digital technology in psychiatry, particularly for schizophrenia and other serious mental health disorders, should be integrated into treatment with professional supervision rather than as a self-treatment tool.
On the Content of Information Systems Ontologies
Authors: Tambassi Timothy 
Published: April 2021

AbstractDespite the fact that information systems ontologies [ISOs] support the mutual understanding between human beings and software applications, human beings and software applications do not understand ISOs' contents in the same way. The same applies to ontological integration. This paper attempts to account for such discrepancies by emphasizing that while human being can have access to entities represented in ISOs, software applications cannot.
Effects of DNA preservation solution and DNA extraction methods on microbial community profiling of soil
Authors: Iturbe-Espinoza Paul , Brandt Bernd W. , Braster Martin , Bonte Matthijs , Brown David M. , van Spanning Rob J. M. 
Published: April 2021

AbstractMicrobial community profiling using high-throughput sequencing relies in part on the preservation of the DNA and the effectiveness of the DNA extraction method. This study aimed at understanding to what extent these parameters affect the profiling. We obtained samples treated with and without a preservation solution. Also, we compared DNA extraction kits from Qiagen and Zymo-Research. The types of samples were defined strains, both as single species and mixtures, as well as undefined indigenous microbial communities from soil. We show that the use of a preservation solution resulted in substantial changes in the 16S rRNA gene profiles either due to an overrepresentation of Gram-positive bacteria or to an underrepresentation of Gram-negative bacteria. In addition, 16S rRNA gene profiles were substantially different depending on the type of kit that was used for extraction. The kit from Zymo extracted DNA from different types of bacteria in roughly equal amounts. In contrast, the kit from Qiagen preferentially extracted DNA from Gram-negative bacteria while DNA from Gram-positive bacteria was extracted less effectively. These differences in kit performance strongly influenced the interpretation of our microbial ecology studies.
Valorisation of Coffee Roasting By-Products: Recovery of Silverskin Fat By Supercritical CO2 Extraction
Authors: Nasti Rita , Galeazzi Andrea , Marzorati Stefania , Zaccheria Federica , Ravasio Nicoletta , Bozzano Giulia Luisa , Manenti Flavio , Verotta Luisella 
Published: April 2021

AbstractRecovery of agro and food-industrial waste and their valorisation via green technologies can help to outline new concepts of industrial strategies. In this contest, a fat enriched of added-value components was extracted from coffee silverskin by applying a supercritical fluid extraction technique (sc-CO2). An appropriate modulation of process parameters like temperature (T = 35, 50, 60 °C) and pressure (p = 200–300 bar) influences the fat yield and the chemical composition, opening the way for targeted extraction. The extraction time, the organic solvent use and the energy consume were reduced compared to Soxhlet. Moreover, a mathematical model was constructed based on the experimental data collected, employed apparatus, and physico-chemical characteristics of biomass, pointing to a possible industrial scale-up. The experimental results are accompanied by a preliminary cost of manufacturing (COM), highlighting how the high investment for the apparatus is compensated by several benefits.
Graphic Abstract
Nephroblastoma overexpressed protein (NOV) enhances 5-Fu-mediated inhibitory effect of colorectal cancer cell proliferation via JNK/AP-1/caspase-8/caspase-3 pathway
Authors: Wang Dong , Wang Tingting , An Yongbo , Jin Lan , Wang Jin , Wu Guocong , Yao Hongwei , Zhang Zhongtao , Li Jun 
Published: April 2021

AbstractChemoresistance often occurs during 5-fluorouracil (5-Fu) treatment of colorectal cancer (CRC). It is significant to explore the potential strategies to sensitize colorectal cancer cells to 5-Fu treatment. We studied the sensitization of Nephroblastoma overexpressed protein (NOV) on 5-Fu treatment. NOV was overexpressed and knocked down in HT115 and RKO cells respectively. Cell proliferation experiments and related mechanism studies by RT-qPCR and Western blot were performed Subsequently. Nude mouse xenograft model was established to test the inhibitory effect of 5-FU on CRC cells in vivo. In this study, we found that NOV mRNA expression was significantly lower in tumor tissues than that in the normal tissues (P < 0.05). The cell proliferation was reduced in the HT115-NOVexp groups (P < 0.05) and increased in the RKO-NOVkd groups (P < 0.05) than that in the control groups and NC groups. The RT-PCR and Western Blot results showed that NOV inhibited the expression of activator protein (AP)-1 (P < 0.05) and promoted the expression of Caspase-8/3 (P < 0.05) in CRC cells in vitro. NOV also improved the inhibitory effect of 5-Fu on inhibiting colorectal cancer proliferation in a tumor cell xenotransplantation nude mouse model. NOV inhibited the expression of AP-1 and JUK and promoted the expression of Caspase-8/3 in cancer tissues in a tumor cell xenotransplantation nude mouse model. In summary, NOV can sensitize CRC cells towards 5-Fu-mediated inhibitory effect on cell proliferation and its sensitization may be achieved by the JNK/AP-1/Caspase-8/Caspase-3 pathway.
Impacts of wastewater discharge from Kalar city on Diyala-Sirwan river water quality, Iraq: pollution evaluation, health risks of heavy metals contamination
Authors: Issa Hayder Mohammed , Alshatteri Azad H. 
Published: April 2021

AbstractIn this work, a comprehensive assessment has been performed to understand impact of wastewater discharge from Kalar city on water quality parameters of Diyala-Sirwan river, Iraq. Levels of physicochemical parameters of Ca, K, Na, Mg, pH, electrical conductivity, dissolved oxygen, total dissolved solid, turbidity, biological oxygen demand, and total hardness, and heavy metals of Fe, Mn, Ni, Cu, Zn, Hg, Al, Ba, Se, and As have been determined by inductively coupled plasma optical emission spectroscopy and other devices. Pollution indices, health risk assessment, and multivariate analysis have been applied to evaluate pollution intensity originated from wastewater discharge on river water quality at different locations, before and after the impact point. Pollution levels of slight to moderate have been identified using different indices for the river water at all sampling locations after the wastewater discharge point. Cluster and correlation analyses showed that the impact of wastewater discharge on the river water quality was occurring along the river within the study area. Non-carcinogenic health risk assessment for heavy metals in the river, indicating a potential risk, might on people's health, especially after discharge point. Furthermore, a significant effect of carcinogenic risk by heavy metals of As and Hg was recognized in the same area. This study thus helps to understand clearly the alteration that happened in the water quality of Diyala-Sirwan river due to the discharge of untreated wastewater from Kalar city.
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation
Authors: Xia Shiyu , Chen Zhenhang , Shen Chen , Fu Tian-Min 
Published: April 2021

AbstractSignaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune cells. Higher-order assemblies have recently emerged as a central principle that governs immune signaling and, by extension, cellular communication in general. There are mainly two types of higher-order assemblies: 1) ordered, solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions, and 2) liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular interactions. This review covers key examples of both types of higher-order assemblies in major immune pathways. By placing emphasis on the molecular structures of the examples provided, we discuss how their structural organization enables elegant mechanisms of signaling regulation.
Symmetric products, linear representations and trace identities
Authors: Vaccarino Francesco 
Published: April 2021

AbstractWe give the equations of then-th symmetric product$$X^n/S_n$$Xn/Snof a flat affine scheme$$X=\mathrm {Spec}\,A$$X=SpecAover a commutative ringF. As a consequence, we find a closed immersion into the coarse moduli space parameterizingn-dimensional linear representations ofA. This is done by exhibiting an isomorphism between the ring of symmetric tensors overAand the ring generated by the coefficients of the characteristic polynomial of polynomials in commuting generic matrices giving representations ofA. Using this we derive an isomorphism of the associated reduced schemes over an infinite field. When the characteristic is zero we show that this isomorphism is an isomorphism of schemes and we express it in term of traces.
Accelerate the optimization of large-scale manufacturing planning using game theory
Authors: Zhen Hui-Ling , Wang Zhenkun , Li Xijun , Zhang Qingfu , Yuan Mingxuan , Zeng Jia 
Published: April 2021

AbstractThis paper studies a real-world manufacturing problem, which is modeled as a bi-objective integer programming problem. The variables and constraints involved are usually numerous and dramatically vary according to the manufacturing data. It is very challenging to directly solve such large-scale problems using heuristic algorithms or commercial solvers. Considering that the decision space of such problems is usually sparse and has a block-like structure, we propose to use decomposition methods to accelerate the optimization process. However, the existing decomposition methods require that the problem has strict block structures, which is not suitable for our problem. To deal with problems with such block-like structures, we propose a game theory based decomposition algorithm. This new method can overcome the large-scale issue and guarantee convergence to some extent, as it can narrow down the search space and accelerate the convergence. Extensive experimental results on real-world industrial manufacturing planning problems show that our method is more effective than the world fastest commercial solver Gurobi. The results also indicate that our method is less sensitive to the problem scale comparing with Gurobi.
Multi-objective System Design Optimization via PPA and a Fuzzy Method
Authors: Mellal Mohamed Arezki , Salhi Abdellah 
Published: April 2021

AbstractSystem design deals with various challenges of targets and resources, such as reliability, availability, maintainability, cost, weight, volume, and configuration. This paper deals with the multi-objective system availability and cost optimization of parallel–series systems by resorting to the multi-objective strawberry algorithm also known as the Plant Propagation Algorithm or PPA and a fuzzy method. It is the first implementation of this optimization algorithm in the literature for this kind of problem to generate the Pareto Front. The fuzzy method allows helping the decision maker to select the best compromise solution. A numerical case study involving 10 subsystems highlights the applicability of the proposed approach.