bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deterministic global optimization with Gaussian processes embedded
Authors: Schweidtmann Artur M. , Bongartz Dominik , Grothe Daniel , Kerkenhoff Tim , Lin Xiaopeng , Najman Jaromił , Mitsos Alexander 
Published: June 2021

AbstractGaussian processes (Kriging) are interpolating data-driven models that are frequently applied in various disciplines. Often, Gaussian processes are trained on datasets and are subsequently embedded as surrogate models in optimization problems. These optimization problems are nonconvex and global optimization is desired. However, previous literature observed computational burdens limiting deterministic global optimization to Gaussian processes trained on few data points. We propose a reduced-space formulation for deterministic global optimization with trained Gaussian processes embedded. For optimization, the branch-and-bound solver branches only on the free variables and McCormick relaxations are propagated through explicit Gaussian process models. The approach also leads to significantly smaller and computationally cheaper subproblems for lower and upper bounding. To further accelerate convergence, we derive envelopes of common covariance functions for GPs and tight relaxations of acquisition functions used in Bayesian optimization including expected improvement, probability of improvement, and lower confidence bound. In total, we reduce computational time by orders of magnitude compared to state-of-the-art methods, thus overcoming previous computational burdens. We demonstrate the performance and scaling of the proposed method and apply it to Bayesian optimization with global optimization of the acquisition function and chance-constrained programming. The Gaussian process models, acquisition functions, and training scripts are available open-source within the “MeLOn—MachineLearning Models for Optimization” toolbox (https://git.rwth-aachen.de/avt.svt/public/MeLOn).
Intratumoral gene expression of dihydrofolate reductase and folylpoly-c-glutamate synthetase affects the sensitivity to 5-fluorouracil in non-small cell lung cancer
Authors: Sakon Kayo , Sasaki Masato , Tanaka Kaede , Mizunaga Tae , Yano Keita , Kawamura Yuuko , Okada Akitoshi , Ikeda Takeshi , Tanabe Sawaka , Takamori Atsushi , Yamada Narihisa , Morioka Kouichi , Koshiji Takaaki 
Published: June 2021

Abstract
Background
Various factors related to the sensitivity of non-small cell lung carcinoma (NSCLC) to 5-fluorouracil (5-FU) have been reported, and some of them have been clinically applied. In this single-institutional prospective analysis, the mRNA expression level of five folic acid-associated enzymes was evaluated in surgical specimens of NSCLC. We investigated the correlation between the antitumor effect of 5-FU in NSCLC using an anticancer drug sensitivity test and the gene expression levels of five enzymes.

Materials and methods
Forty patients who underwent surgery for NSCLC were enrolled, and the antitumor effect was measured using an in vitro anticancer drug sensitivity test (histoculture drug response assay) using freshly resected specimens. In the same sample, the mRNA expression levels of five enzymes involved in the sensitivity to 5-FU were measured in the tumor using real-time PCR. The expression levels and the result of the sensitivity test were compared.

Results
No correlation was found between dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), or DPD/OPRT expression and the antitumor effects of 5-FU. On the other hand, a correlation was found between thymidylate synthase (TS), folylpoly-c-glutamate synthetase (FPGS), and dihydrofolate reductase (DHFR) expression and 5-FU sensitivity.

Conclusion
Expression of FPGS and DHFR may be useful for predicting the efficacy of 5-FU-based chemotherapy for NSCLC.
Improved Process Monitoring Scheme Using Multi-Scale Independent Component Analysis
Authors: Kini K Ramakrishna , Madakyaru Muddu 
Published: June 2021

AbstractThe task of fault detection is crucial in modern chemical industries for improved product quality and process safety. In this regard, data-driven fault detection (FD) strategy based on independent component analysis (ICA) has gained attention since it improves monitoring by capturing non-gaussian features in the process data. However, presence of measurement noise in the process data degrades performance of the FD strategy since the noise masks important information. To enhance the monitoring under noisy environment, wavelet-based multi-scale filtering is integrated with the ICA model to yield a novel multi-scale Independent component analysis (MSICA) FD strategy. One of the challenges in multi-scale ICA modeling is to choose the optimum decomposition depth. A novel scheme based on ICA model parameter estimation at each depth is proposed in this paper to achieve this. The effectiveness of the proposed MSICA-based FD strategy is illustrated through three case studies, namely: dynamic multi-variate process, quadruple tank process and distillation column process. In each case study, the performance of the MSICA FD strategy is assessed for different noise levels by comparing it with the conventional FD strategies. The results indicate that the proposed MSICA FD strategy can enhance performance for higher levels of noise in the data since multi-scale wavelet-based filtering is able to de-noise and capture efficient information from noisy process data.
Understanding the Value of Energy Storage for Power System Reliability and Resilience Applications
Authors: Balducci Patrick , Mongird Kendall , Weimar Mark 
Published: June 2021

AbstractPurpose of ReviewThe need for energy storage in the electrical grid has grown in recent years in response to a reduced reliance on fossil fuel baseload power, added intermittent renewable investment, and expanded adoption of distributed energy resources. While the methods and models for valuing storage use cases have advanced significantly in recent years, the value of enhanced resilience remains an open research question.Recent FindingsThe findings of the recent research indicate that energy storage provides significant value to the grid, with median benefit values for specific use cases ranging from under $10/kW-year for voltage support to roughly $100/kW-year for capacity and frequency regulation services. While the value of lost load is used widely to estimate the benefits of mitigating short-duration outages, reaching as high as $719/kilowatt-year, there is no consensus when it comes to monetizing the value of improving grid resilience.SummaryThis paper presents a use case taxonomy for energy storage and uses the taxonomy to conduct a meta-analysis of an extensive set of energy storage valuation studies. It reviews several approaches for monetizing reliability and resiliency services and presents a proposed approach for valuing resiliency for energy storage investments.
Acute kidney injury (AKI) in patients with Covid-19 infection is associated with ventilatory management with elevated positive end-expiratory pressure (PEEP)
Authors: Ottolina Davide , Zazzeron Luca , Trevisi Letizia , Agarossi Andrea , Colombo Riccardo , Fossali Tommaso , Passeri Mattia , Borghi Beatrice , Ballone Elisabetta , Rech Roberto , Castelli Antonio , Catena Emanuele , Nebuloni Manuela , Gallieni Maurizio 
Published: June 2021

Abstract
Background
Acute kidney injury (AKI) in Covid-19 patients admitted to the intensive care unit (ICU) is common, and its severity may be associated with unfavorable outcomes. Severe Covid-19 fulfills the diagnostic criteria for acute respiratory distress syndrome (ARDS); however, it is unclear whether there is any relationship between ventilatory management and AKI development in Covid-19 ICU patients.

Purpose
To describe the clinical course and outcomes of Covid-19 ICU patients, focusing on ventilatory management and factors associated with AKI development.

Methods
Single-center, retrospective observational study, which assessed AKI incidence in Covid-19 ICU patients divided by positive end expiratory pressure (PEEP) tertiles, with median levels of 9.6 (low), 12.0 (medium), and 14.7 cmH2O (high-PEEP).

Results
Overall mortality was 51.5%. AKI (KDIGO stage 2 or 3) occurred in 38% of 101 patients. Among the AKI patients, 19 (53%) required continuous renal replacement therapy (CRRT). In AKI patients, mortality was significantly higher versus non-AKI (81% vs. 33%, p < 0.0001). The incidence of AKI in low-, medium-, or high-PEEP patients were 16%, 38%, and 59%, respectively (p = 0.002). In a multivariate analysis, high-PEEP patients showed a higher risk of developing AKI than low-PEEP patients (OR = 4.96 [1.1–21.9] 95% CI p < 0.05). ICU mortality rate was higher in high-PEEP patients, compared to medium-PEEP or low-PEEP patients (69% vs. 44% and 42%, respectively; p = 0.057).

Conclusion
The use of high PEEP in Covid-19 ICU patients is associated with a fivefold higher risk of AKI, leading to higher mortality. The cause and effect relationship needs further analysis.

Graphic abstract
Chinese Bureaucracy Through Three Lenses: Weberian, Confucian, and Marchian
Authors: Zhou Xueguang 
Published: June 2021

ABSTRACTChinese bureaucracy, with its long history and distinctive characteristics, has provided the organizational basis of governance and played a pivotal role in the economic takeoff in recent decades. Chinese bureaucracy also shows intriguing dualism between entrepreneurial activism and bureaucratic inertia, between formal rules and informal institutions, and between high responsiveness and noticeable loose coupling. In this study, I explore these distinctive features of Chinese bureaucracy through three lenses: Weber's comparative-historical approach helps locate Chinese bureaucracy in a distinct mode of domination; the Confucian lens identifies the prevalence of informal institutions that underlie bureaucratic behaviors; and the Marchian lens sheds light on the organized anarchy and set of mechanisms that shape the key characteristics of Chinese bureaucracy.
A 25,000 year record of climate and vegetation change from the southwestern Cape coast, South Africa
Authors: Quick Lynne J. , Chase Brian M. , Carr Andrew S. , Chevalier Manuel , Grobler B. Adriaan , Meadows Michael E. 
Published: June 2021

AbstractThe southwestern Cape of South Africa is a particularly dynamic region in terms of long-term climate change. We analysed fossil pollen from a 25,000 year sediment core taken from a near-coastal wetland at Pearly Beach that revealed that distinct changes in vegetation composition occurred along the southwestern Cape coast. From these changes, considerable variability in temperature and moisture availability are inferred. Consistent with indications from elsewhere in southwestern Africa, variability in Atlantic Meridional Overturning Circulation (AMOC) was identified as a strong determinant of regional climate change. At Pearly Beach, this resulted in phases of relatively drier conditions (~24–22.5 cal ka BP and ~22–18 cal ka BP) demarcated by brief phases of increased humidity from ~24.5–24 cal ka BP and 22.5–22 cal ka BP. During glacial Termination I (~19–11.7 ka), a marked increase in coastal thicket pollen from ~18.5 to 15.0 cal ka BP indicates a substantial increase in moisture availability, coincident, and likely associated with, a slowing AMOC and a buildup of heat in the southern Atlantic. With clear links to glacial and deglacial Earth system dynamics and perturbations, the Pearly Beach record represents an important new contribution to a growing body of data, providing insights into the patterns and mechanisms of southwestern African climate change.
Nutrition within the household: 18th through early 20thcentury female and male statures
Authors: Carson Scott Alan 
Published: June 2021

AbstractWhen other measures for material conditions are scarce or unreliable, the use of height is now common to evaluate economic conditions during economic development. However, throughout US economic development, height data by gender have been slow to emerge. Throughout the late 19thand early 20thcenturies, female and male statures remained constant. Agricultural workers had taller statures than workers in other occupations, and the female agricultural height premium was over twice that of males. For both females and males, individuals with fairer complexions were taller than their darker complexioned counterparts. Gender collectively had the greatest explanatory effect associated with stature, followed by age and nativity. Socioeconomic status and birth period had the smallest collective effects with stature.
Omega-3 fatty acid intake during pregnancy and risk of infant maltreatment: a nationwide birth cohort – the Japan Environment and Children's Study
Authors: Matsumura Kenta , Hamazaki Kei , Tsuchida Akiko , Inadera Hidekuni ,   the Japan Environment and Children's Study (JECS) Group
Published: June 2021

AbstractBackgroundIntake of omega-3 polyunsaturated fatty acids (PUFAs) has favorable effects, including reducing violent and aggressive behaviors, but its association with infant maltreatment is unknown. We therefore tested the hypothesis that maternal intake of omega-3 PUFAs is associated with a lower risk of infant maltreatment.MethodsParticipants were 92 191 mothers involved in the ongoing Japan Environment and Children's Study. Omega-3 PUFA intake during pregnancy was measured using a food frequency questionnaire. Infant maltreatment was assessed using a self-reported questionnaire administered at 1 and 6 months postpartum.ResultsAnalysis using the lowest quintile of intake as a reference revealed that the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for cases of ‘hitting’ decreased as quintiles increased, with values for the second to fifth quintiles of 0.93 (95% CI 0.77–1.13), 0.79 (95% CI 0.64–0.97), 0.78 (95% CI 0.64–0.96), and 0.72 (95% CI 0.59–0.89), respectively. Adjusted ORs (95% CIs) for ‘shaking very hard’ at 6 months were 0.87 (0.73–1.04), 0.81 (0.67–0.97), 0.73 (0.61–0.89), and 0.78 (0.65–0.94), respectively. Adjusted ORs for ‘leaving alone at home’ for the second to fifth quintiles were 0.92 (0.87–0.98), 0.91 (0.86–0.97), 0.94 (0.88–0.99), and 0.85 (0.80–0.90), respectively.ConclusionsHigher maternal intake of omega-3 PUFAs during pregnancy was associated with fewer cases of hitting and violent shaking and leaving the child alone at home, implying a lower risk of infant maltreatment. Our results indicate the potential applicability of omega-3 PUFAs in reducing infant maltreatment.
The influence of prominence cues in 7- to 10-year-olds’ pronoun resolution: Disentangling order of mention, grammatical role, and semantic role
Authors: BLYTHING Liam P. , IRAOLA AZPIROZ Maialen , ALLEN Shanley , HERT Regina , JÄRVIKIVI Juhani 
Published: June 2021

AbstractIn two visual world experiments we disentangled the influence of order of mention (first vs. second mention), grammatical role (subject vs object), and semantic role (proto-agent vs proto-patient) on 7- to 10-year-olds’ real-time interpretation of German pronouns. Children listened to SVO or OVS sentences containing active accusative verbs (küssen “to kiss”) in Experiment 1 (N = 72), or dative object-experiencer verbs (gefallen “to like”) in Experiment 2 (N = 64). This was followed by the personal pronoun er or the demonstrative pronoun der. Interpretive preferences for er were most robust when high prominence cues (first mention, subject, proto-agent) were aligned onto the same entity; and the same applied to der for low prominence cues (second mention, object, proto-patient). These preferences were reduced in conditions where cues were misaligned, and there was evidence that each cue independently influenced performance. Crucially, individual variation in age predicted adult-like weighting preferences for semantic cues (Schumacher, Roberts & Järvikivi, 2017).
Lithostratigraphy, age and distribution of Eocene volcanic sequences on eastern King George Island, South Shetland Islands, Antarctica
Authors: Smellie John L. , Hunt Richard J. , Mcintosh William C. , Esser Richard P. 
Published: June 2021

AbstractNew mapping and dating of volcanic outcrops on the east coast of Admiralty Bay, King George Island, has demonstrated that Eocene volcanic sequences are dominant and also crop out extensively elsewhere, particularly on the eastern part of the island. The sequences can be divided into at least three formations (Hennequin, Cape Vauréal and Carruthers Cliff) together with Eocene strata at Warkocz and near Lions Rump that are currently unassigned stratigraphically. New and recently published40Ar/39Ar ages indicate that all of the formations are Early Eocene in age, mainly Ypresian, extending to Lutetian and possibly even Priabonian time in more easterly outcrops. Compositional contrasts exist between the groups (calc-alkalinevstholeiitic). The formations are mainly composed of lavas, and many show evidence for contemporary inundation by water. They are interbedded with sedimentary rocks deposited mainly during flooding events as debris flows, debris avalanches, hyperconcentrated flows, from traction currents and in lakes. The common presence of juvenile volcanic detritus suggests that the sediments were probably linked to explosive hydrovolcanic eruptions, some of which were possibly rooted in summit ice caps. Other evidence is also permissive, but the presence of Eocene ice on King George Island is not well established at present.
Rapid Response to the 2019 Ridgecrest Earthquake With Distributed Acoustic Sensing
Authors: Li Zefeng , Shen Zhichao , Yang Yan , Williams Ethan , Wang Xin , Zhan Zhongwen 
Published: June 2021

AbstractRapid seismic deployments after major earthquakes often produce critical data for characterizing postseismic processes. Taking advantage of pre‐existing optical fibers, the recently emerging distributed acoustic sensing (DAS) technology can quickly establish ultra‐dense seismic arrays after the mainshocks. Here we present the first example of such a rapid‐response experiment using four telecommunication fiber optic cables near the 2019 M 7.1 Ridgecrest earthquake in California. By applying template matching to the Ridgecrest DAS array, we detected 6 times more aftershocks than the standard catalog within the three‐month period. The enhanced catalog reveals abundant aftershocks on multiple crosscutting faults near the epicenters of the mainshock and the M 6.4 foreshock. Given the widespread fiber optic networks around the world, DAS has the potential to deliver fast and high‐resolution aftershock monitoring and promote better understanding of earthquake physics.
Multi‐Decadal Carbon Cycle Measurements Indicate Resistance to External Drivers of Change at the Howland Forest AmeriFlux Site
Authors: Hollinger D. Y. , Davidson E. A. , Fraver S. , Hughes H. , Lee J. T. , Richardson A. D. , Savage K. , Sihi D. , Teets A. 
Published: June 2021

AbstractA long‐standing goal of ecology has been to understand the cycling of carbon in forests. This has taken on new urgency with the need to address a rapidly changing climate. Forests serve as long‐term stores for atmospheric CO2, but their continued ability to take up new carbon is dependent on future changes in climate and other factors such as age. We have been measuring many aspects of carbon cycling at an unmanaged evergreen forest in central Maine, USA, for over 25 years. Here we use these data to address questions about the magnitude and control of carbon fluxes and quantify flows and uncertainties between the different pools. A key issue was to assess whether recent climate change and an aging tree population were reducing annual C storage. Total ecosystem C stocks determined from inventory and quantitative soil pits were about 23,300 g C m−2with 46% in live trees, and 48% in the soil. Annual biomass increment in trees at Howland Forest averaged 161 ± 23 g C m−2 yr−1, not significantly different from annual net ecosystem production (NEP = −NEE) of 211 ± 40 g C m−2 y−1measured by eddy covariance. Unexpectedly, there was a small but significant trend of increasing C uptake through time in the eddy flux data. This was despite the period of record including some of the most climate‐extreme years in the last 125. We find a surprising lack of influence of climate variability on annual carbon storage in this mature forest.
A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function
Authors: Honecker Julius , Weidlich Dominik , Heisz Simone , Lindgren Cecilia M. , Karampinos Dimitrios C. , Claussnitzer Melina , Hauner Hans 
Published: June 2021

AbstractObjectiveCell diameter, area, and volume are established quantitative measures of adipocyte size. However, these different adipocyte sizing parameters have not yet been directly compared regarding their distributions. Therefore, the study aimed to investigate how these adipocyte size measures differ in their distribution and assessed their correlation with anthropometry and laboratory chemistry. In addition, we were interested to investigate the relationship between fat cell size and adipocyte mitochondrial respiratory chain capacity.MethodsSubcutaneous and visceral histology-based adipocyte size estimates from 188 individuals were analyzed by applying a panel of parameters to describe the underlying cell population. Histology-based adipocyte diameter distributions were compared with adipocyte diameter distributions from collagenase digestion. Associations of mean adipocyte size with body mass index (BMI), glucose, HbA1C, blood lipids as well as mature adipocyte mitochondrial respiration were investigated.ResultsAll adipocyte area estimates derived from adipose tissue histology were not normally distributed, but rather characterized by positive skewness. The shape of the size distribution depends on the adipocyte sizing parameter and on the method used to determine adipocyte size. Despite different distribution shapes histology-derived adipocyte area, diameter, volume, and surface area consistently showed positive correlations with BMI. Furthermore, associations between adipocyte sizing parameters and glucose, HbA1C, or HDL specifically in the visceral adipose depot were revealed. Increasing subcutaneous adipocyte diameter was negatively correlated with adipocyte mitochondrial respiration.ConclusionsDespite different underlying size distributions, the correlation with obesity-related traits was consistent across adipocyte sizing parameters. Decreased mitochondrial respiratory capacity with increasing subcutaneous adipocyte diameter could display a novel link between adipocyte hypertrophy and adipose tissue function.