bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenic Assessment of SfMNPV-Based Biopesticide on Spodoptera frugiperda (Lepidoptera: Noctuidae) Developing on Transgenic Soybean Expressing Cry1Ac Insecticidal Protein
Authors: Zakseski Marcelo R , da Silva Filho José G , Rakes Matheus , Pazini Juliano de B , da Rosa Ana Paula S A , Marçon Paula , Popham Holly J R , Bernardi Oderlei , Bernardi Daniel 
Published: September 2021

Abstract
Pathogenic assessment of a baculovirus-based biopesticide containing Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV: Baculoviridae: Alphabaculovirus) infecting fall armyworm, Spodoptera frugiperda (J. E. Smith, 1797) (Lepidoptera: Noctuidae) is reported. In the bioassays, neonates were infected with different doses of SfMNPV applied on Cry1Ac Bt soybean and non-Bt soybean. Our findings indicated that S. frugiperda neonates did not survive at 10 d post infection or develop into adults on Bt and non-Bt soybean sprayed with the field recommended dose of SfMNPV. In contrast, a proportion of the infected neonates developed into adults when infected with lower doses of SfMNPV (50%, 25%, and 10% of field dose) in both Bt and non-Bt soybean. However, S. frugiperda neonates surviving infection at the lowest virus doses on both soybean varieties showed longer neonate-to-pupa and neonate-to-adult periods, lower larval and pupal weights, reduced fecundity, and increased population suppression. Nevertheless, more pronounced pathogenicity of SfMNPV infecting neonates of S. frugiperda were verified on larvae that developed on Bt soybean. These findings revealed that, beyond mortality, the biopesticide containing SfMNPV also causes significant sublethal pathogenic effects on neonates of S. frugiperda developing on Bt and non-Bt soybean and suggested an additive effect among SfMNPV and Cry1Ac insecticidal protein expressed in Bt soybean.
Electromagnetic propagation logging while drilling data acquisition method based on undersampling technology
Authors: Li Xinghan , Zhang Wenxiu , Chen Wenxuan , Zhang Yali , Zheng Jian , Fan Jianbao , Li Hong , Ma Zhenjun 
Published: September 2021

Abstract
With the development of complex and unconventional reservoirs, oil and gas exploration becomes increasingly difficult. Highly deviated wells/horizontal wells are widely used. The electromagnetic propagation logging while drilling (LWD) is more effective in complex geological environment detection owing to geological orientation and real-time formation evaluation. However, its operating frequency is generally at the MHz level. Traditional acquisition techniques require an analogue to digital converter with high sampling rates, which will introduce complex circuit structures and increase sampling costs. The undersampling technology has overcome these disadvantages. The difficulties in the undersampling technology include the selection of an undersampling frequency and the acquisition of a signal correction coefficient. The range of undersampling frequencies and a correction coefficient has been developed to process the electromagnetic propagation LWD measurements in this paper. The range of undersampling frequency ensures the validity of the sampled data. The correction coefficient ensures that different frequency signals use the same undersampling frequency to obtain the same frequency recovery signal. The correctness of these parameters is verified by simulation and field data examples. The range of undersampling frequency and a correction coefficient has been applied, improving the data stability and providing reliable technical support for the exploration and development of unconventional oil and gas.
Characterization and Phylogenetic Analysis of the Complete Mitochondrial Genomes of Two Tiny Necrophagous Phorid Flies, Metopina sagittata and Puliciphora borinquenensis (Diptera: Phoridae)
Authors: Dai Shu-Tong , Feng Dian-Xing , Sun Da-Peng 
Published: September 2021

Abstract
The mitochondrial genome is frequently used for species identification and phylogenetic studies. In this study, we first sequenced and annotated the complete mitochondrial genomes of two phorid species that are forensically important in buried or enclosed environments: Metopina sagittata (Liu) and Puliciphora borinquenensis (Wheeler). The complete mitochondrial genome sequences of M. sagittata and P. borinquenensis were 15,640 bp with an A+T content of 75.97% and 15,429 bp with an A+T content of 75.38%, respectively. Their circular genomes both contained 13 protein-coding genes (PCGs), 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 control region located between rrnS and trnI which was 808 bp for M. sagittata and 746 bp for P. borinquenensis. All the PCGs of both species started with ATN codons except for cox1 which used TTG codon. In addition to the common stop codon TAA and TAG, the incomplete stop codon T was used in two PCGs (cox1 and nad4) of M. sagittata and five PCGs (cox1, cox2, cox3, nad5, and nad4) of P. borinquenensis. There were 3 and 10 mismatched base pairs in the tRNA secondary structures from M. sagittata and P. borinquenensis, respectively. Both maximum likelihood and Bayesian inference analyses indicated that Platypezidae and Phoridae are sister taxa. M. sagittata is closely related to P. borinquenensis within the subfamily Metopininae. This work enhances the databases of Phoridae genomes and contributes to the further study of species identification and phylogenetics of this family.
Neural Injury and Repair in a Novel Neonatal Mouse Model of Listeria Monocytogenes Meningoencephalitis
Authors: Seele Jana , Ballüer Melissa , Tauber Simone C , Bunkowski Stephanie , Schulz Katja , Stadelmann Christine , Beineke Andreas , Pägelow Dennis , Fulde Marcus , Nau Roland 
Published: September 2021

Abstract
To improve the therapy of neonatal central nervous system infections, well-characterized animal models are urgently needed. The present study analyzes neuropathological alterations with particular focus on neural injury and repair in brains of neonatal mice with Listeria monocytogenes (LM) meningitis/meningoencephalitis using a novel nasal infection model. The hippocampal formation and frontal cortex of 14 neonatal mice with LM meningitis/meningoencephalitis and 14 uninfected controls were analyzed by histology, immunohistochemistry, and in situ tailing for morphological alterations. In the dentate gyrus of the hippocampal formation of mice with LM meningitis/meningoencephalitis, an increased density of apoptotic neurons visualized by in situ tailing (p = 0.04) and in situ tailing plus immunohistochemistry for activated Caspase-3 (p &lt; 0.0001) was found. A decreased density of dividing cells stained with an anti-PCNA-antibody (p &lt; 0.0001) and less neurogenesis visualized by anti-calretinin (p &lt; 0.0001) and anti-calbindin (p = 0.01) antibodies were detected compared to uninfected controls. The density of microglia was higher in LM meningitis (p &lt; 0.0001), while the density of astrocytes remained unchanged. Infiltrating monocytes and neutrophilic granulocytes likely contributed to tissue damage. In conclusion, in the brains of LM-infected mice a strong immune response was observed which led to neuronal apoptosis and an impaired neural regeneration. This model appears very suitable to study therapies against long-term sequelae of neonatal LM meningitis.
Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status
Authors: Kloske Courtney M , Dugan Adam J , Weekman Erica M , Winder Zachary , Patel Ela , Nelson Peter T , Fardo David W , Wilcock Donna M 
Published: September 2021

Abstract
Alzheimer disease (AD) is a neurodegenerative disease characterized by a cognitive decline leading to dementia. The most impactful genetic risk factor is apolipoprotein E (APOE). APOE-ε4 significantly increases AD risk, APOE-ε3 is the most common gene variant, and APOE-ε2 protects against AD. However, the underlying mechanisms of APOE-ε4 on AD risk remains unclear, with APOE-ε4 impacting many pathways. We investigated how the APOE isoforms associated with the neuroinflammatory state of the brain with and without AD pathology. Frozen brain tissue from the superior and middle temporal gyrus was analyzed from APOE-ε3/3 (n = 9) or APOE-ε4/4 (n = 10) participants with AD pathology and APOE-ε3/3 (n = 9) participants without AD pathology. We determined transcript levels of 757 inflammatory related genes using the NanoString Human Neuroinflammation Panel. We found significant pathways impaired in APOE-ε4/4-AD individuals compared to APOE-ε3/3-AD. Of interest, expression of genes related to microglial activation (SALL1), motility (FSCN1), epigenetics (DNMT1), and others showed altered expression. Additionally, we performed immunohistochemistry of P2RY12 to confirm reduced microglial activation. Our results suggest APOE-ε3 responds to AD pathology while potentially having a harmful long-term inflammatory response, while APOE-ε4 shows a weakened response to pathology. Overall, APOE isoforms appear to modulate the brain immune response to AD-type pathology.
Wearable Sensors Detect Movement Differences in the Portable Warrior Test of Tactical Agility After mTBI in Service Members
Authors: Favorov Oleg , Kursun Olcay , Challener Timothy , Cecchini Amy , McCulloch Karen L 
Published: September 2021

ABSTRACTIntroductionAssessment of functional recovery of service members following a concussion is central to their return to duty. Practical military-relevant performance-based tests are needed for identifying those who might need specialized rehabilitation, for evaluating the progress of recovery, and for making return-to-duty determinations. One such recently developed test is the ‘Portable Warrior Test of Tactical Agility’ (POWAR-TOTAL) assessment designed for use following concussion in an active duty population. This agility task involves maneuvers used in military training, such as rapid stand-to-prone and prone-to-stand transitions, combat rolls, and forward and backward running. The effect of concussion on the performance of such maneuvers has not been established.Materials and MethodsThe Institutional Review Board–approved study was conducted at Ft. Bragg, North Carolina, on 57 healthy control (HC) service members (SMs) and 42 well-matched SMs who were diagnosed with concussion and were referred for physical therapy with the intent to return to duty. Each study participant performed five consecutive trials of the POWAR-TOTAL task at full exertion while wearing inertial sensors, which were used to identify the constituent task maneuvers, or phases, and measure their durations. Statistical analyses were performed on durations of three main phases: (1) rising from prone and running, (2) lowering from vertical to prone, and (3) combat rolls.ResultsNone of the three phases showed significant correlation with age (range 18-45 years) in either group. Gradual improvement in all three phase durations across five trials was observed in the HC group, but not in the concussed group. On average, control subjects performed significantly faster (P &lt; .004 or less) than concussed subjects in all trials in the lowering and rolling phases, but less so in the rising/running phase. Membership in the concussed group had a strong effect on the lowering phase (Cohen’s d = 1.05), medium effect on the rolling phase (d = 0.72), and small effect on the rising/running phase (d = 0.49). Individuals in the HC group who had a history of prior concussions were intermediate between the concussed group and the never-concussed group in the lowering and rolling phases. Duration of transitional movements (lowering from standing to prone and combat rolls) was better at differentiating individuals’ performance by group (receiver operating characteristic area under the curve [AUC] = 0.83) than the duration of the entire POWAR-TOTAL task (AUC = 0.71).ConclusionsInertial sensor analysis reveals that rapid transitional movements (such as lowering from vertical to prone position and combat rolls) are particularly discriminative between SMs recovering from concussion and their concussion-free peers. This analysis supports the validity of POWAR-TOTAL as a useful tool for therapists who serve military SMs.
Local neuronal relational structures underlying the contents of human conscious experience
Authors: Malach Rafael 
Published: September 2021

AbstractWhile most theories of consciousness posit some kind of dependence on global network activities, I consider here an alternative, localist perspective—in which localized cortical regions each underlie the emergence of a unique category of conscious experience. Under this perspective, the large-scale activation often found in the cortex is a consequence of the complexity of typical conscious experiences rather than an obligatory condition for the emergence of conscious awareness—which can flexibly shift, depending on the richness of its contents, from local to more global activation patterns. This perspective fits a massive body of human imaging, recordings, lesions and stimulation data but opens a fundamental problem: how can the information, defining each content, be derived locally in each cortical region. Here, I will discuss a solution echoing pioneering structuralist ideas in which the content of a conscious experience is defined by its relationship to all other contents within an experiential category. In neuronal terms, this relationship structure between contents is embodied by the local geometry of similarity distances between cortical activation patterns generated during each conscious experience, likely mediated via networks of local neuronal connections. Thus, in order for any conscious experience to appear in an individual’s mind, two central conditions must be met. First, a specific configural pattern (“bar-code”) of neuronal activity must appear within a local relational geometry, i.e. a cortical area. Second, the individual neurons underlying the activated pattern must be bound into a unified functional ensemble through a burst of recurrent neuronal firing: local “ignitions”.
Clinical and Pregnancy Outcomes of Coronavirus Disease 2019 Among Hospitalized Pregnant Women in the United States
Authors: Ackerman Christina M , Nguyen Jennifer L , Ambati Swapna , Reimbaeva Maya , Emir Birol , Cabrera Javier , Benigno Michael , Malhotra Deepa , Hammond Jennifer , Bahtiyar Mert Ozan 
Published: September 2021

Abstract

Background
Pregnant women with coronavirus disease 2019 (COVID-19) may be at greater risk of poor maternal and pregnancy outcomes. This retrospective analysis reports clinical and pregnancy outcomes among hospitalized pregnant women with COVID-19 in the United States.

Methods
The Premier Healthcare Database—Special Release was used to examine the impact of COVID-19 among pregnant women aged 15–44 years who were hospitalized and who delivered compared with pregnant women without COVID-19. Outcomes evaluated were COVID-19 clinical progression, including the use of supplemental oxygen therapy, intensive care unit admission, critical illness, receipt of invasive mechanical ventilation/extracorporeal membrane oxygenation, maternal death, and pregnancy outcomes, including preterm delivery and stillbirth.

Results
Overall, 473 902 hospitalized pregnant women were included, 8584 (1.8%) of whom had a COVID-19 diagnosis (mean age = 28.4 [standard deviation = 6.1] years; 40% Hispanic). The risk of poor clinical and pregnancy outcomes was greater among pregnant women with COVID-19 compared with pregnant women without a COVID-19 diagnosis in 2020; the risk of poor clinical and pregnancy outcomes increased with increasing age. Hispanic and Black non-Hispanic women were consistently observed to have the highest relative risk of experiencing poor clinical or pregnancy outcomes across all age groups.

Conclusions
Overall, COVID-19 had a significant negative impact on maternal health and pregnancy outcomes. These data help inform clinical practice and counseling to pregnant women regarding the risks of COVID-19. Clinical studies evaluating the safety and efficacy of vaccines against severe acute respiratory syndrome coronavirus 2 in pregnant women are urgently needed.
Quantum noise and vacuum fluctuations in balanced homodyne detections through ideal multi-mode detectors
Authors: Nakamura Kouji 
Published: September 2021

Abstract
The balanced homodyne detection as a readout scheme of gravitational-wave detectors is carefully examined from the quantum field theoretical point of view. The readout scheme in gravitational-wave detectors specifies the directly measured quantum operator in the detection. This specification is necessary when we apply the recently developed quantum measurement theory to gravitational-wave detections. We examine the two models of measurement. One is the model in which the directly measured quantum operator at the photodetector is Glauber’s photon number operator, and the other is the model in which the power operator of the optical field is directly measured. These two are regarded as ideal models of photodetectors. We first show these two models yield the same expectation value of the measurement. Since there is consensus in the gravitational-wave community that vacuum fluctuations contribute to the noises in the detectors, we also clarify the contributions of vacuum fluctuations to the quantum noise spectral density without using the two-photon formulation which is used in the gravitational-wave community. We found that the conventional noise spectral density in the two-photon formulation includes vacuum fluctuations from the main interferometer but does not include those from the local oscillator. Although the contribution of vacuum fluctuations from the local oscillator theoretically yields the difference between the above two models in the noise spectral densities, this difference is negligible in realistic situations.
Center group dominance in quark confinement
Authors: Ikeda Ryu , Kondo Kei-Ichi 
Published: September 2021

Abstract
We show that the color $N$-dependent area law falloffs of the double-winding Wilson loop averages for the $SU(N)$ lattice gauge theory obtained in previous works are reproduced from the corresponding lattice Abelian gauge theory with the center gauge group $Z_N$. This result indicates the center group dominance in quark confinement.
Seed-Stage Success and Growth of Angel Co-investment Networks*
Authors: Venugopal Buvaneshwaran , Yerramilli Vijay 
Published: September 2021

Abstract
Using hand-collected data, we show that coinvestment is widespread in the angel investment market, even among seed-stage startups. Individual angels with demonstrated seed-stage success experience an increase in the quantity, quality, and geographic and industry spread of their coinvestment connections relative to unsuccessful peers and are rewarded with more deal flow. These results are stronger for less-established angels and for angels whose successes are more indicative of their ability. Success also begets more success: the portfolio companies of successful angels are more likely to receive follow-on financing, especially from VC firms. Our results highlight how angels grow their coinvestment networks. (JEL G24, L14, L26, M13).
The effect of deoxynivalenol-contaminated corn and an immune-modulating feed additive on growth performance and immune response of nursery pigs fed corn- and soybean meal-based diets
Authors: Lafleur Larivière Élise , Zhu Cuilan , Zettell Sabrina , Patterson Robert , Karrow Niel A , Huber Lee-Anne 
Published: September 2021

Abstract
One hundred eighty newly weaned pigs (21 days of age; 6.9 ± 0.2 kg BW) were used to determine the effects of deoxynivalenol- (DON) contaminated corn and an immune-modulating feed additive on growth performance and immune response of nursery pigs fed corn- and soybean meal-based diets. Pens were randomly assigned to one of five diets: a high-complexity (HC; containing animal protein sources) or one of four low-complexity diets (LC; containing soybean meal as the main protein source) arranged in a 2 × 2 factorial with low (lDON; average 1.4 ppm) or high (hDON; average 3.5 ppm) DON and with or without a feed additive (2 g/kg in complete feed; n = 6 pens per treatment) provided in a three-phase feeding program. On day 7, small intestinal histomorphology was assessed in two pigs per pen. On days 8 and 25, two pigs per pen were immunized with ovalbumin (OVA). Blood was collected on days 8, 25, and 38 for determination of OVA-specific IgG. There were no corn type by feed additive interactions or feed additive effects for growth performance. The ADG, ADFI, and G:F in phase I were not different for pigs fed hDON vs. lDON, but were less than those fed the HC diet (contrasts; P &lt; 0.05). Over the entire nursery period, ADG and ADFI were less for pigs fed hDON vs. those fed lDON (407 vs. 484 g and 651 vs. 769 g, respectively; P &lt; 0.05), ADG was less for pigs fed hDON vs. HC (496 g; P &lt; 0.05), and pigs fed lDON had ADG and ADFI not different from those fed the HC diet. Pigs fed hDON had lower final BW than those fed lDON (24.6 vs. 27.6 kg; P &lt; 0.01) and tended to have lower final BW than pigs fed the HC diet (27.3 kg; contrast; P = 0.052); final BW was not different between pigs fed lDON and HC diets. Jejunal villus heights were shorter for pigs fed hDON and lDON compared to pigs fed HC (438 and 466 vs. 538 µm; contrasts; P &lt; 0.05 and P = 0.090, respectively) and the villus:crypt ratio tended to be less for pigs fed hDON vs. those fed HC (1.87 vs. 2.22; contrast; P = 0.091). On day 38, plasma OVA-specific IgG 1 tended to be less for pigs fed hDON compared to HC (contrast; P = 0.075) and OVA-specific total IgG were less for pigs fed LC diets without the feed additive vs. HC (P &lt; 0.05). Therefore, high DON (~3.5 ppm) in LC nursery diets interfered with compensatory growth and the humoral immune response. The feed additive did not rescue growth performance, regardless of DON contamination level in LC nursery diets.
Opposition Media, State Censorship, and Political Accountability: Evidence from Chavez’s Venezuela
Authors: Knight Brian , Tribin Ana 
Published: September 2021

Abstract
This study investigates the effects of state censorship in the context of the 2007 government closing of RCTV, a popular opposition television channel in Venezuela. Some parts of the country had access to a second opposition channel, Globovision, while other parts completely lost access to opposition television. The first finding, based upon ratings data, is that viewership fell on the progovernment replacement, following the closing of RCTV, but rose on Globovision in areas with access to the signal. Based upon this switching, the paper investigates whether support for Chavez fell in areas that retained access to opposition television, relative to those that completely lost access. Using three measures, Latinbarometer survey data, electoral returns, and data on protest activity, the second finding is that support for Chavez fell in municipalities that retained access to opposition television, relative to municipalities that lost access to opposition television. Taken together, these two findings suggest that voters switching from censored outlets to uncensored outlets can limit the effectiveness of state censorship.