bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing pasireotide-associated hyperglycemia: a randomized, open-label, Phase IV study
Authors: Samson Susan L. , Gu Feng , Feldt-Rasmussen Ulla , Zhang Shaoling , Yu Yerong , Witek Przemysław , Kalra Pramila , Pedroncelli Alberto M. , Pultar Philippe , Jabbour Nadine , Paul Michaela , Bolanowski Marek 
Published: July 2021

Abstract
Purpose
Pasireotide is an effective treatment for acromegaly and Cushing’s disease, although treatment-emergent hyperglycemia can occur. The objective of this study was to assess incretin-based therapy versus insulin for managing pasireotide-associated hyperglycemia uncontrolled by metformin/other permitted oral antidiabetic drugs.

Methods
Multicenter, randomized, open-label, Phase IV study comprising a core phase (≤ 16-week pre-randomization period followed by 16-week randomized treatment period) and optional extension (ClinicalTrials.gov ID: NCT02060383). Adults with acromegaly (n = 190) or Cushing’s disease (n = 59) received long-acting (starting 40 mg IM/28 days) or subcutaneous pasireotide (starting 600 µg bid), respectively. Patients with increased fasting plasma glucose (≥ 126 mg/dL on three consecutive days) during the 16-week pre-randomization period despite metformin/other oral antidiabetic drugs were randomized 1:1 to open-label incretin-based therapy (sitagliptin followed by liraglutide) or insulin for another 16 weeks. The primary objective was to evaluate the difference in mean change in HbA1c from randomization to end of core phase between incretin-based therapy and insulin treatment arms.

Results
Eighty-one (32.5%) patients were randomized to incretin-based therapy (n = 38 received sitagliptin, n = 28 subsequently switched to liraglutide; n = 12 received insulin as rescue therapy) or insulin (n = 43). Adjusted mean change in HbA1c between treatment arms was – 0.28% (95% CI – 0.63, 0.08) in favor of incretin-based therapy. The most common AE other than hyperglycemia was diarrhea (incretin-based therapy, 28.9%; insulin, 30.2%). Forty-six (18.5%) patients were managed on metformin (n = 43)/other OAD (n = 3), 103 (41.4%) patients did not require any oral antidiabetic drugs and 19 patients (7.6%) were receiving insulin at baseline and were not randomized.

Conclusion
Many patients receiving pasireotide do not develop hyperglycemia requiring oral antidiabetic drugs. Metformin is an effective initial treatment, followed by incretin-based therapy if needed.
ClinicalTrials.gov ID: NCT02060383.
Emergencies: on the misuse of government powers
Authors: Bjørnskov Christian , Voigt Stefan 
Published: July 2021

AbstractNine out of 10 constitutions contain explicit emergency provisions, intended to help governments cope with extraordinary events that endanger many people or the existence of the state. We ask two questions: (1) does the constitutionalization of emergency provisions help governments to cope with disasters and other extraordinary events? (2) What particular parts of emergency constitutions fare best? We find that the more advantages emergency constitutions confer to the executive, the higher the number of people killed as a consequence of a natural disaster, controlling for its severity. As this is an unexpected result, we discuss a number of potential explanations, the most plausible being that governments use natural disasters as a pretext to enhance their power. Furthermore, the easier it is to call a state of emergency, the larger the negative effects on basic human rights. Interestingly, presidential democracies are better able to cope with natural disasters than parliamentary ones in terms of lives saved, whereas autocracies do significantly worse in the sense that empowerment rights seriously suffer in the aftermath of a disaster.
Quality of life in urologic cancer patients: importance of and satisfaction with specific quality of life domains
Authors: Leuteritz Katja , Richter Diana , Mehnert-Theuerkauf Anja , Stolzenburg Jens-Uwe , Hinz Andreas 
Published: July 2021

Abstract
Purpose
Quality of life (QoL) has been the subject of increasing interest in oncology. Most examinations of QoL have focused on health-related QoL, while other factors often remain unconsidered. Moreover, QoL questionnaires implicitly assume that the subjective importance of the various QoL domains is identical from one patient to the next. The aim of this study was to analyze QoL in a broader sense, considering the subjective importance of the QoL components.

Methods
A sample of 173 male urologic patients was surveyed twice: once while hospitalized (t1) and once again 3 months later (t2). Patients completed the Questions on Life Satisfaction questionnaire (FLZ-M), which includes satisfaction and importance ratings for eight dimensions of QoL. A control group was taken from the general population (n = 477).

Results
Health was the most important QoL dimension for both the patient and the general population groups. While satisfaction with health was low in the patient group, the satisfaction ratings of the other seven domains were higher in the patient group than in the general population. The satisfaction with the domain partnership/sexuality showed a significant decline from t1 to t2. Multiple regression analyses showed that the domains health and income contributed most strongly to the global QoL score at t2 in the patient group.

Conclusion
Health is not the only relevant category when assessing QoL in cancer patients; social relationships and finances are pertinent as well. Importance ratings contribute to a better understanding of the relevance of the QoL dimensions for the patients.
Brain drain and brain gain in Russia: Analyzing international migration of researchers by discipline using Scopus bibliometric data 1996–2020
Authors: Subbotin Alexander , Aref Samin 
Published: July 2021

AbstractWe study international mobility in academia, with a focus on the migration of published researchers to and from Russia. Using an exhaustive set of over 2.4 million Scopus publications, we analyze all researchers who have published with a Russian affiliation address in Scopus-indexed sources in 1996–2020. The migration of researchers is observed through the changes in their affiliation addresses, which altered their mode countries of affiliation across different years. While only 5.2% of these researchers were internationally mobile, they accounted for a substantial proportion of citations. Our estimates of net migration rates indicate that while Russia was a donor country in the late 1990s and early 2000s, it has experienced a relatively balanced circulation of researchers in more recent years. These findings suggest that the current trends in scholarly migration in Russia could be better framed as brain circulation, rather than as brain drain. Overall, researchers emigrating from Russia outnumbered and outperformed researchers immigrating to Russia. Our analysis on the subject categories of publication venues shows that in the past 25 years, Russia has, overall, suffered a net loss in most disciplines, and most notably in the five disciplines of neuroscience, decision sciences, mathematics, biochemistry, and pharmacology. We demonstrate the robustness of our main findings under random exclusion of data and changes in numeric parameters. Our substantive results shed light on new aspects of international mobility in academia, and on the impact of this mobility on a national science system, which have direct implications for policy development. Methodologically, our novel approach to handling big data can be adopted as a framework of analysis for studying scholarly migration in other countries.
“Never Again the Everyday”: On Cinema, Colportage and the Pedagogical Possibilities of Escapism
Authors: Hållander Marie 
Published: July 2021

AbstractThis article is a philosophical analysis of escapism as a pedagogical possibility, with a particular focus on TV series. Taking my own, as well as students, experience of escapism into TV series as a starting point, that is, their ability take us somewhere far away, something which has become more acute during the pandemic time since we remain more or less self-isolated because of the corona virus Covid-19, the article discusses escapism in relation to distraction and attention in life as well as within teaching, but also in relation to colportage, hope and social justice. According to Ernst Bloch, social justice cannot materialize without regarding things differently. Something that is often dismissed as mere escapism might be a seed for a new and more humane social order, as it can be seen as an “immature, but honest substitute for revolution” (Bloch 1986, p. 368). Drawing on Bloch’s understanding of colportage and hope, as well as Walter Benjamin’s understanding of mass culture and cinema, the article treats escapism and TV series not as something simple, but rather as possible seeds for a new social order and thus as having pedagogical possibilities (Hållander, 2020).
Social constructivism in mathematics? The promise and shortcomings of Julian Cole’s institutional account
Authors: Rytilä Jenni 
Published: July 2021

AbstractThe core idea of social constructivism in mathematics is that mathematical entities are social constructs that exist in virtue of social practices, similar to more familiar social entities like institutions and money. Julian C. Cole has presented an institutional version of social constructivism about mathematics based on John Searle’s theory of the construction of the social reality. In this paper, I consider what merits social constructivism has and examine how well Cole’s institutional account meets the challenge of accounting for the characteristic features of mathematics, especially objectivity and applicability. I propose that in general social constructivism shows promise as an ontology of mathematics, because the view can agree with mathematical practice and it offers a way of understanding how mathematical entities can be real without conflicting with a scientific picture of reality. However, I argue that Cole’s specific theory does not provide an adequate social constructivist account of mathematics. His institutional account fails to sufficiently explain the objectivity and applicability of mathematics, because the explanations are weakened and limited by the three-level theoretical model underlying Cole’s account of the construction of mathematical reality and by the use of the Searlean institutional framework. The shortcomings of Cole’s theory give reason to suspect that the Searlean framework is not an optimal way to defend the view that mathematical reality is socially constructed.
The B-type natriuretic peptide of the Congo and Timneh grey parrot
Authors: Hennig Anja , Mohr L. , Fehr M. , Legler M. 
Published: July 2021

AbstractIn captivity, cardiovascular diseases are common in grey parrots. The diagnosis of these diseases in living birds is difficult, and new diagnostic possibilities would be desirable. The heart is an important endocrine organ in which cardiomyocytes synthetise B-type natriuretic peptide (BNP) and release it into the bloodstream. This hormone has a significant role in cardiovascular and body fluid regulation. The blood concentration of BNP is used in human medicine and small animal medicine as a diagnostic tool in the identification of heart diseases and as a prognostic marker for the risk of mortality. The nucleotide and amino acid sequence of BNP was described in Congo (n = 4) and Timneh (n = 3) grey parrots by PCR after RNA isolation from the atria and ventricles. The results showed a high similarity between the nucleotide sequences of the grey parrots’ BNP and the already known sequence of this hormone in chickens. The amino acid sequence of the mature peptide region is consistent in these three species. BNP plasma concentration could be a possible blood parameter for identifying clinically manifest cardiovascular diseases in grey parrots as it is in other species.
Multi-level Governance in Refugee Housing and Integration Policy: a Model of Best Practice in Leverkusen
Authors: Auslender Eli 
Published: July 2021

AbstractThis paper will explore a model of best practice, the Leverkusen Model, as well as its impact on both the city and the refugees it serves by utilising key stakeholder interviews, civil servants, non-profits, and Syrian refugees living in Leverkusen. The core argument to be presented here is that the dynamic fluidity of the Leverkusen Model, where three bodies (government, Caritas, and the Refugee Council) collaborate to manage the governance responsibilities, allows for more expedited refugee integration into society. This paper utilises an analytical model of multi-level governance to demonstrate its functional processes and show why it can be considered a model of best practice. Started in 2002, the Leverkusen Model of refugee housing has not only saved the city thousands of euros per year in costs associated with refugee housing, but has aided in the cultivation of a very direct, fluid connection between government, civil society, and the refugees themselves. Leverkusen employs a different and novel governance structure of housing for refugees: with direct consultations with Caritas, the largest non-profit in Germany, as well as others, refugees who arrive in Leverkusen are allowed to search for private, decentralised housing from the moment they arrive, regardless of protection status granted by the German government. This paper fills a gap in the existing literature by addressing the adaptation of multi-level governance and collaborative governance in local refugee housing and integration management.
Progress and perspectives in dielectric energy storage ceramics
Authors: Li Dongxu , Zeng Xiaojun , Li Zhipeng , Shen Zong-Yang , Hao Hua , Luo Wenqin , Wang Xingcai , Song Fusheng , Wang Zhumei , Li Yueming 
Published: July 2021

AbstractDielectric ceramic capacitors, with the advantages of high power density, fast charge-discharge capability, excellent fatigue endurance, and good high temperature stability, have been acknowledged to be promising candidates for solid-state pulse power systems. This review investigates the energy storage performances of linear dielectric, relaxor ferroelectric, and antiferroelectric from the viewpoint of chemical modification, macro/microstructural design, and electrical property optimization. Research progress of ceramic bulks and films for Pb-based and/or Pb-free systems is summarized. Finally, we propose the perspectives on the development of energy storage ceramics for pulse power capacitors in the future.
Teaching geriatric medicine through gamification: a tool for enhancing postgraduate education in geriatric medicine
Authors: Schlögl Mathias , Roller-Wirnsberger Regina Elisabeth , Hernes Susanne Sørensen , Perkisas Stany , Bakken Marit Stordal , Miot Stéphanie , Balci Cafer , Dani Melanie , Pajulammi Hanna , Piaggi Paolo , Drenth-van Maanen Clara , Singler Katrin 
Published: July 2021

Abstract
Background
Polypharmacy is becoming increasingly common and all doctors must be prepared to manage it competently.

Aims
The aim of this project is to evaluate the feasibility and use of a novel gamification-based teaching intervention on polypharmacy among doctors undergoing advanced geriatric training. Among others, one of the learning goals for the students was to be able to describe the adherence to medication.

Methods
Electronic questionnaire sent to students of the third session “evidence-based medicine in geriatrics” of advanced postgraduate course in geriatrics of the European Academy for Medicine of Ageing.

Results
Most students reported issues with forgetting doses and remembering sufficiently to establish a medication routine due to busy schedules as well as social influences around medication taking. Reflecting on the challenges of the game, most students reported that their own prescribing practice was likely to change.

Discussion and conclusion
The current model of learning appears to be a feasible approach for postgraduate medical education or in other areas of healthcare such as nursing or physiotherapy. Learning through action and reflection promotes deeper thinking and can lead to behavioral change, in this case thus enhancing the attitudes and understanding regarding pharmacological issues associated with ageing. Recommendations for future research in medical education about medication adherence are outlined.
Europe, public debts, and safe assets: the scope for a European Debt Agency
Authors: Amato Massimo , Belloni Everardo , Falbo Paolo , Gobbi Lucio 
Published: July 2021

AbstractThe Covid-19 crisis has radically changed the game for world and EU-economies, and urged for a reappraisal of the guidelines for a healthy management of public expenditure. This requires a deep rethinking of the role of public debt in modern capitalistic economies and of efficient, equitable and politically viable ways of financing it. This paper outlines the main operating framework of a Debt Agency tasked with the management of the Eurozone sovereign debts and the creation of a truly European safe asset. The framework leverages on the potential irredeemable nature of sovereign debts in order to build a common bond. By structurally filtering liquidity risk, the Debt Agency can price the Member States’ funding costs by referring only to their credit risk, as defined by EU agreed rules. The common bond issued by the Debt Agency thus avoids mutualisation by design; hence, it can be directly bought by the ECB. Due to its structural intertemporal sustainability, the Debt Agency’s framework delineated in this paper can serve as a benchmark for institutional and political decisions. In this perspective, a counterfactual exercise has been conducted in order to evaluate the future potential impact of the Debt Agency as well as the past distortions in market pricing of Member States’ fundamental risk due to market mispricing of the liquidity risk.
Molecular Phenomic Approaches to Deconvolving the Systemic Effects of SARS-CoV-2 Infection and Post-acute COVID-19 Syndrome
Authors: Nicholson Jeremy K. 
Published: July 2021

AbstractSARS COV-2 infection causes acute and frequently severe respiratory disease with associated multi-organ damage and systemic disturbances in many biochemical pathways. Metabolic phenotyping provides deep insights into the complex immunopathological problems that drive the resulting COVID-19 disease and is also a source of novel metrics for assessing patient recovery. A multiplatform metabolic phenotyping approach to studying the pathology and systemic metabolic sequelae of COVID-19 is considered here, together with a framework for assessing post-acute COVID-19 Syndrome (PACS) that is a major long-term health consequence for many patients. The sudden emergence of the disease presents a biological discovery challenge as we try to understand the pathological mechanisms of the disease and develop effective mitigation strategies. This requires technologies to measure objectively the extent and sub-phenotypes of the disease at the molecular level. Spectroscopic methods can reveal metabolic sub-phenotypes and new biomarkers that can be monitored during the acute disease phase and beyond. This approach is scalable and translatable to other pathologies and provides as an exemplar strategy for the investigation of other emergent zoonotic diseases with complex immunological drivers, multi-system involvements and diverse persistent symptoms.
Sensational Science, Archaic Hominin Genetics, and Amplified Inductive Risk
Authors: Havstad Joyce C. 
Published: July 2021

AbstractMore than a decade of exacting scientific research involving paleontological fragments and ancient DNA has lately produced a series of pronouncements about a purportedly novel population of archaic hominins dubbed “the Denisova.” The science involved in these matters is both technically stunning and, socially, at times a bit reckless. Here I discuss the responsibilities which scientists incur when they make inductively risky pronouncements about the different relative contributions by Denisovans to genomes of members of apparent subpopulations of current humans (i.e., the so-called “races”). This science is sensational: it is science which empirically speculates, to the public delight’s and entertainment, about scintillating topics such as when humans evolved, where we came from, and who else we were having sex with during our early hominin history. An initial characterization of sensational science emerges from my discussion of the case, as well as a diagnosis of an interactive phenomenon termed amplified inductive risk.
Examining Legal Scholarship in Australia: A Case Study
Authors: Sheehy Benedict , Dumay John 
Published: July 2021

AbstractLegal scholarship in Australia is under-researched. Without detailed empirical investigation, it is difficult to understand the characteristics of the scholarship in terms of topics and method/approach. Legal scholarship, like all scholarship, claims to make a contribution to knowledge. To understand and evaluate the scholarship, this article adopts an empirical method. Using a case study approach and citation counts, the article provides an analysis of all the articles published by a leading law review over ten years: 2008–2018. The article identifies the types and methods of legal scholarship in the journal and examines a sample of its most highly cited articles. The study then evaluates the impact of this scholarship with recommendations for the future.
THE EARLY KURGAN PERIOD IN RABATI, GEORGIA: THE CULTURAL SEQUENCE AND A NEW SUITE OF RADIOCARBON DATES
Authors: Bedianashvili Giorgi , Jamieson Andrew , Sagona Claudia 
Published: July 2021

AbstractThis paper reports on radiocarbon (14C) results from the recent archaeological investigations in the ancient frontier fortress of Rabati, in southwest Georgia, a collaborative research project involving archaeologists from the Georgian National Museum and the University of Melbourne. From the first three excavation seasons spanning 2016, 2018, and 2019, it became clear that significant Bedeni phase deposits capped most of the summit of the site. Levels with their distinctive vessels and a range of contemporary, local domestic wares, pits and some traces of architecture seal underlying Early Bronze Age strata. The Early Bronze Age levels include massive architecture rarely seen in Kura-Araxes settlements. Some finds can only be described as unique and extraordinary while others suggest that the core population was stable with long-held traditions, yet open to new influences infiltrating this highland site during the subsequent Early Kurgan (Martkopi-Bedeni) period. We discuss the key discoveries at Rabati relative to the 14C readings from the site within the wider setting of contemporary sites in the Caucasus.