bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for carotid plaque progression after optimising the risk factor treatment: substudy results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the carotid Bifurcation Plaque Study (ANTIQUE)
Authors: Školoudík David , Kešnerová Petra , Hrbáč Tomáš , Netuka David , Vomáčka Jaroslav , Langová Kateřina , Herzig Roman , Belšan Tomáš 
Published: December 2021

Background and aimCarotid plaque progression contributes to increasing stroke risk. The study aims to identify factors influencing carotid plaque thickness progression after changing the preventive treatment to the ‘treating arteries instead of risk factors’ strategy, that is, change in treatment depending on the progression of atherosclerosis.MethodsThe study participants who completed sonographic controls over the course of 3 years were enrolled to the analysis. Duplex sonography of cervical arteries was performed in 6-month intervals with measurement of carotid plaque thickness. Plaque thickness measurement error (σ) was set as 3 SD. Only evidently stable and progressive plaques (defined as plaque thickness difference between initial and final measurements of ˂σ and >2σ, respectively) were included to analysis. Univariate and multivariate logistic regression analysis was performed to identify factors influencing plaque progression.ResultsA total of 1391 patients (466 males, age 67.2±9.2 years) were enrolled in the study. Progressive plaque in at least one carotid artery was detected in 255 (18.3%) patients. Older age, male sex, greater plaque thickness, coronary heart disease, vascular surgery/stenting history and smoking were more frequently present in patients with progressive plaque (p˂0.05 in all cases). Multivariate logistic regression analysis identified only the plaque thickness (OR 1.850 for left side, 95% CI 1.398 to 2.449; and OR 1.376 for right side, 95% CI 1.070 to 1.770) as an independent factor influencing plaque progression.ConclusionCarotid plaque thickness corresponding to stenosis severity is the only independent risk factor for plaque thickness progression after optimising the prevention treatment.Trial registration numberNCT02360137.
CT pectoralis muscle area is associated with DXA lean mass and correlates with emphysema progression in a tobacco-exposed cohort
Authors: O'Brien Michael Emmet , Zou Richard H , Hyre Nathan , Leader Joseph K , Fuhrman Carl R , Sciurba Frank C , Nouraie Mehdi , Bon Jessica 
Published: December 2021

IntroductionMuscle loss is an important extrapulmonary manifestation of COPD. Dual energy X-ray absorptiometry (DXA) is the method of choice for body composition measurement but is not widely used for muscle mass evaluation. The pectoralis muscle area (PMA) is quantifiable by CT and predicts cross-sectional COPD-related morbidity. There are no studies that compare PMA with DXA measures or that evaluate longitudinal relationships between PMA and lung disease progression.MethodsParticipants from our longitudinal tobacco-exposed cohort had baseline and 6-year chest CT (n=259) and DXA (n=164) data. Emphysema was quantified by CT density histogram parenchymal scoring using the 15th percentile technique. Fat-free mass index (FFMI) and appendicular skeletal mass index (ASMI) were calculated from DXA measurements. Linear regression model relationships were reported using standardised coefficient (β) with 95% CI.ResultsPMA was more strongly associated with DXA measures than with body mass index (BMI) in both cross-sectional (FFMI: β=0.76 (95% CI 0.65 to 0.86), p<0.001; ASMI: β=0.76 (95% CI 0.66 to 0.86), p<0.001; BMI: β=0.36 (95% CI 0.25 to 0.47), p<0.001) and longitudinal (ΔFFMI: β=0.43 (95% CI 0.28 to 0.57), p<0.001; ΔASMI: β=0.42 (95% CI 0.27 to 0.57), p<0.001; ΔBMI: β=0.34 (95% CI 0.22 to 0.46), p<0.001) models. Six-year change in PMA was associated with 6-year change in emphysema (β=0.39 (95% CI 0.23 to 0.56), p<0.001) but not with 6-year change in airflow obstruction.ConclusionsPMA is an accessible measure of muscle mass and may serve as a useful clinical surrogate for assessing skeletal muscle loss in smokers. Decreased PMA correlated with emphysema progression but not lung function decline, suggesting a difference in the pathophysiology driving emphysema, airflow obstruction and comorbidity risk.
Sensitivity of multi-PMT optical modules in Antarctic ice to supernova neutrinos of MeV energy
Authors: Lozano Mariscal C. J. , Classen L. , Unland Elorrieta M. A. , Kappes A. 
Published: December 2021

AbstractNew optical sensors with a segmented photosensitive area are being developed for the next generation of neutrino telescopes at the South Pole. In addition to increasing sensitivity to high-energy astrophysical neutrinos, we show that this will also lead to a significant improvement in sensitivity to MeV neutrinos, such as those produced in core-collapse supernovae (CCSN). These low-energy neutrinos can provide a detailed picture of the events after stellar core collapse, testing our understanding of these violent explosions. We present studies on the event-based detection of MeV neutrinos with a segmented sensor and, for the first time, the potential of a corresponding detector in the deep ice at the South Pole for the detection of extra-galactic CCSN. We find that exploiting temporal coincidences between signals in different photocathode segments, a $$27\ \mathrm {M}_{\odot }$$

27

M
⊙

progenitor mass CCSN can be detected up to a distance of 341 kpc with a false detection rate of $${0.01}\,\hbox {year}^{-1}$$

0.01

year

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1

with a detector consisting of 10,000 sensors. Increasing the number of sensors to 20,000 and reducing the optical background by a factor of 70 expands the range such that a CCSN detection rate of 0.1 per year is achieved, while keeping the false detection rate at $${0.01}\,{\hbox {year}^{-1}}$$

0.01

year

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1

.
Emergent universe revisited through the CSL theory
Authors: Bengochea Gabriel R. , Piccirilli María Pía , León Gabriel 
Published: December 2021

AbstractIn this work we analyze how the spectrum of primordial scalar perturbations is modified, within the emergent universe scenario, when a particular version of the Continuous Spontaneous Localization (CSL) model is incorporated as the generating mechanism of initial perturbations, providing also an explanation to the quantum-to-classical transition of such perturbations. On the other hand, a phase of super-inflation, prior to slow-roll inflation, is a characteristic feature of the emergent universe hypothesis. In recent works, it was shown that the super-inflation phase could generically induce a suppression of the temperature anisotropies of the CMB at large angular scales. We study here under what conditions the CSL maintains or modifies these characteristics of the emergent universe and their compatibility with the CMB observations.
Generalized compact star models with conformal symmetry
Authors: Jape J. W. , Maharaj S. D. , Sunzu J. M. , Mkenyeleye J. M. 
Published: December 2021

AbstractWe generate a new generalized regular charged anisotropic exact model that admits conformal symmetry in static spherically symmetric spacetime. Our model was examined for physical acceptability as realistic stellar models. The regularity is not violated, the energy conditions are satisfied, the physical forces balanced at equilibrium, the stability is satisfied via adiabatic index, and the surface red shift and mass–radius ratio are within the required bounds. Our conformal charged anisotropic exact solution contains models generated by Finch–Skea, Vaidya–Tikekar and Schwarzschild. Also, some recent charged or neutral and anisotropic or isotropic conformally symmetric models are found as special cases of our exact model. Our approach using a conformal symmetry provides a generalized geometric framework for studying compact objects.
E-Cadherin: Context-Dependent Functions of a Quintessential Epithelial Marker in Metastasis
Authors: Fang Cao , Kang Yibin 
Published: December 2021

Abstract
Loss of E-cadherin expression has been well known as a hallmark of epithelial–mesenchymal transition (EMT), which is linked to increased risk of cancer metastasis. However, it was less clear whether E-cadherin and its downstream signaling pathways are functionally involved in driving EMT and the prometastatic phenotype. A study by Onder and colleagues in 2008 discovered that E-cadherin loss not only helps tumor cells detach from each other by breaking down cell–cell junctions but also elicits intracellular signaling events to confer a mesenchymal cell state and metastatic phenotype. This study established E-cadherin as an important global regulator, rather than just a marker, of EMT. The discovery inspired further investigation in the following decade that significantly deepened our understanding of E-cadherin and its diverse functions and more broadly of cellular plasticity in different stages and contexts of cancer metastasis.
See related article by Onder and colleagues, Cancer Res 2008;68:3645–3654.
Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial
Authors: Blair Gordon W. , Janssen Esther , Stringer Michael S. , Thrippleton Michael J. , Chappell Francesca , Shi Yulu , Hamilton Iona , Flaherty Katie , Appleton Jason P. , Doubal Fergus N. , Bath Philip M. , Wardlaw Joanna M. 
Published: December 2021

Background and Purpose:
Cerebral small vessel disease—a major cause of stroke and dementia—is associated with cerebrovascular dysfunction. We investigated whether short-term isosorbide mononitrate (ISMN) and cilostazol, alone or in combination, improved magnetic resonance imaging–measured cerebrovascular function in patients with lacunar ischemic stroke.

Methods:
Participants were randomized to ISMN alone, cilostazol alone, both ISMN and cilostazol, or no medication. Participants underwent structural, cerebrovascular reactivity (to 6% carbon dioxide) and phase-contrast pulsatility magnetic resonance imaging at baseline and after 8 weeks of medication.

Results:
Of 27 participants (mean age, 68±7.7; 44% female), 22 completed cerebrovascular reactivity and pulsatility imaging with complete datasets. White matter cerebrovascular reactivity increased in the ISMN (β=0.021%/mm Hg [95% CI, 0.003–0.040]) and cilostazol (β=0.035%/mm Hg [95% CI, 0.014–0.056]) monotherapy groups and in those taking any versus no medication (β=0.021%/mm Hg [95% CI, 0.005–0.037]).

Conclusions:
While limited by small sample size, we demonstrate that measuring cerebrovascular function with magnetic resonance imaging is feasible in clinical trials and that ISMN and cilostazol may improve cerebrovascular function.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02481323. URL:
www.isrctn.com
; Unique identifier: ISRCTN12580546. URL:
www.clinicaltrialsregister.eu
; Unique identifier: EudraCT 2015-001953-33.
Inter-individual differences of calling and exploratory behaviour in a lebinthine cricket species hint at different mate-finding strategies
Authors: Tan Ming Kai , Schöneich Stefan , Robillard Tony 
Published: December 2021

Abstract
Individual fitness can be boosted by behavioural strategies that maximise mate-finding probability while minimising predation risk. Animals that use acoustics to find mates may benefit from using both stationary calling and active exploration, but these also expose them to different types of predators. Studying calling and searching behaviours concurrently allows us to understand their evolutionary trade-offs between survival and reproduction. Unlike most other crickets, lebinthine males alternate between singing and exploration to find females, which offer a unique and excellent opportunity to test for inter-individual differences and behavioural syndrome between call properties and exploratory behaviours. Our data demonstrate that call properties and exploratory behaviour were repeatable. We did not, however, find that call properties correlate with exploration as some consistently exploratory individuals produce longer calls while others produce shorter calls. Our study suggests that lebinthine males use different combinations of calling and exploratory behaviours to cope with unpredictable risk–benefit scenarios.
Case alignment in Kabyle Amazigh
Authors: Felice Lydia 
Published: December 2021

Abstract
This paper examines the state alternation in Kabyle, arguing that state is the morphological realization of Case. The free state is accusative case, and the construct state is nominative case. Taking morphological patterns and syntactic distribution into account, Kabyle is found to be a Type 2 marked nominative language. Both states, or cases, are morphologically marked. The free state is the default case. This analysis accounts for the bulk of the distribution of free state and construct state nouns, and situates Kabyle as belonging to a typologically rare alignment system that is concentrated in Afroasiatic and African languages.
On interdental fricatives in the first-layer dialects of Maghrebi Arabic
Authors: Guerrero Jairo 
Published: December 2021

Abstract
The present paper aims at revisiting the question of interdental fricatives in the so-called pre-Hilali Arabic dialects, that is the descendants of the first stage of Arabicization in North Africa. It attempts to challenge, from a diachronic and comparative approach, the view that the absence of interdental fricatives—and their merger with dental stops—is a hallmark of pre-Hilali Arabic. On the basis of neglected data, we will provide evidence suggesting that interdental phonemes occur or did occur in some of the Arabic dialects which resulted from the early Muslim conquest of North Africa.
A Ḥarsusi text re-examined
Authors: Rubin Aaron D. 
Published: December 2021

Abstract
Ḥarsusi, one of the six languages that comprise the Modern South Arabian branch of the Semitic family, is still rather poorly attested. One of the major sources of information is a small corpus of texts collected by T.M. Johnstone and published posthumously by Harry Stroomer. The errors present in that published edition have a negative impact on our limited understanding of Ḥarsusi grammar and vocabulary. The present article, which includes a re-edition of one of Johnstone’s texts, along with translation and commentary, aims to improve upon our current knowledge of Ḥarsusi.
Arabic loanwords in seven Ethiopian languages
Authors: Alqarni Muteb 
Published: December 2021

Abstract
Within the Theory of Constraints and Repair Strategies (Paradis, 1988a,b; Paradis & LaCharité, 1993, 1997, 2001, 2002, 2005, 2008, henceforth TCRS), we provide a formal analysis to the Arabic loanwords in seven languages spoken in Ethiopia: Ge’ez, Tigre, Tigrinya, Amharic, Harari, Argobba and Gurage. The analysis draws upon a corpus of 540 loanwords extracted from the works of Leslau (1956a,b,c; 1957a,b,c; 1958; 1963; 1990). The article presents theoretical challenges to the TCRS Loanword Model (Paradis & LaCharité, 1997), in particular to the Threshold Principle which stipulates that an illicit segment should universally undergo less than two repairs to be licensed in the borrowing language; beyond this limit, it will be deleted. The adaptations of Arabic segmental malformations in these seven Ethiopian languages, however, exceed this number totaling in certain cases to six repairs. The article also discusses the Arabic gutturals, [ʔ], [ʕ] and [ħ], which undergo unpredictable deletion in Amharic and Argobba, showing that the Non-Availability Hypothesis (Paradis & LaCharité, 2001) cannot account for these deletions either. Although the Francophones systematically delete gutturals in Arabic loanwords due to the non-availability of Pharyngeal node in French, the inventories of Amharic and Argobba include the laryngeal [h], the uvular [q] and the glottalized ejectives, thus employing Pharyngeal node plus the features [RTR] and [constricted glottis] as phonologically treatable primitives.
Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
Authors: Hasegawa Shiori , Inaba Ryoichi , Nakamura Hiroki , Kato Yamato , Nakao Satoshi , Hirade Kouseki , Suzuki Takaaki , Iwata Mari , Kato Takeshi , Iguchi Kazuhiro , Yamada Masahide , Hioki Atsushi , Nakamura Mitsuhiro 
Published: December 2021

The environment and personnel are both exposed to powdered pharmaceuticals inside pharmacies. This makes developing new methods for rapidly determining such contaminants an important objective. In this study, we developed a liquid-chromatography tandem-mass-spectrometry (LC–MS/MS) method for the simultaneous qualitative and quantitative determination of powdered medicinal drugs, such as famotidine, risperidone, lansoprazole, olanzapine, haloperidol, clarithromycin, promethazine, levomepromazine, and chlorpromazine. The method involves the use of acetaminophen as the internal standard, an LC–MS/MS method with a core–shell column, and a 10 mM ammonium formate/acetonitrile gradient mobile phase. The analytes were separated within 14 min, and MS with an electrospray ionization source in positive-ion mode was used. The limits of detection for the 9 drugs were .1-8.4 ng/mL. Linear calibration curves in the 10-50 000 ng/mL range were constructed, and inter-day accuracies of 92.6-113.8% were determined for the 9 drugs. The coefficients of variation were less than 14.6%. These data suggest that the proposed method is applicable for the routine assaying of powdered-medicine contamination in pharmacies.
Apnea–hypopnea index severity as an independent predictor of post-tonsillectomy respiratory complications in pediatric patients: A retrospective study
Authors: Rossi Nicholas A , Spaude Jordan , Ohlstein Jason F , Pine Harold S , Daram Shiva , McKinnon Brian J , Szeremeta Wasyl 
Published: December 2021

Introduction Despite the presence of clinical practice guidelines for overnight admission of pediatric patients following adenotonsillectomy, variance in practice patterns exists between pediatric otolaryngologists. The purpose of this study is to examine severity of apnea–hypopnea index (AHI) as an independent predictor of postoperative respiratory complications in children undergoing adenotonsillectomy. Methods Retrospective chart review of all children undergoing adenotonsillectomy at a large tertiary referral center between January 2015 and December 2019 who underwent preoperative polysomnography and were admitted for overnight observation. Charts were reviewed for total adverse events and respiratory events occurring during admission. Results Overall, respiratory events were seen in 50.6% of patients with AHI ≥10 and in 39.6% of patients with AHI <10. The overall mean AHI was 19.2, with a mean of 28.1 in the AHI ≥10 subgroup vs 4.6 in the AHI <10 subgroup. There was no statistical correlation or increased risk between an AHI ≥10 and having a pure respiratory event, with a relative risk of 1.19 (.77–1.83, P = .43). There was a statistically significant difference between the mean AHI of those with any adverse event and those without (21.6 vs 13.4, P = .008). There is additionally an increased risk of any event with an AHI over 10, with a relative risk of 1.51 (1.22–1.88, P < .0001). Conclusion Preoperative AHI of 10 events per hour was not a predictor of postoperative respiratory complications. However, there was a trend for those with a higher AHI requiring additional supportive measures or a prolonged stay. Practitioners should always use their best judgment in deciding whether a child warrants postoperative admission following adenotonsillectomy.
Polysomnographic Characteristics of the Patients Having Chronic Insomnia and Obstructive Sleep Apnea: Evidence for Paradoxical Insomnia and Comorbid Insomnia with OSA (COMISA)
Authors: Kundu Kaustav , Sharma Gaurav , Saini Lokesh , Gupta Ravi 
Published: December 2021

Background: Sleep state misperception (SSM) is seen among patients with obstructive sleep apnea (OSA) as well as those having insomnia. Moreover, OSA and insomnia can also be comorbid. This study aims at finding the proportion of SSM and “Comorbid Insomnia with OSA” (COMISA) among patients of OSA and chronic insomnia. Macroachitecture of sleep was also compared across groups. Methods: This study utilized the retrospective laboratory and medical records of two groups of patients: chronic insomnia and OSA. Sleep disorders were diagnosed according to standard criteria. Daytime sleepiness was examined using the Epworth Sleepiness Scale. Diagnosis of SSM was based on the difference between subjective and objective sleep onset latency (Subjective SOL > 1.5 × Objective SOL). Results: Sixteen adult subjects were included in each group. Based on the difference between subjective and objective sleep onset latency, SSM was reported by 62.5% subjects of chronic insomnia and 56.25% subjects having OSA (OR = 1.29; 95% CI = 0.31–5.33; P = 0.79). The proportion of COMISA in subjects with chronic insomnia was 18% and among subjects with OSA, it was 43%. Effect size for the proportion was calculated as odds ratio (33.96; 95% CI = 7.48–154.01; P < 0.0002). Thus, the odds for COMISA were higher among subjects with OSA than those with chronic Insomnia. The three groups (OSA, COMISA and Chronic Insomnia) were comparable with regard to the macro-architecture of sleep. Conclusion: SSM is common among subjects with OSA and chronic insomnia. COMISA was commoner among patients with OSA compared to those with chronic insomnia. Macro-architecture of sleep is comparable among groups.
Prevalence of blindness and its major causes in sub-Saharan Africa in 2020: A systematic review and meta-analysis
Authors: Xulu-Kasaba Zamadonda Nokuthula , Kalinda Chester 
Published: December 2021

Background: Global studies show that the prevalence of visual impairment and blindness continued to rise despite the implementation of strategies outlined in the Global Action Plan, aimed at reducing these by the year 2020. Vision impairment impacts negatively on one’s independence, opportunities, and quality of life. Therefore, knowledge of the prevalence, and the major causes of blindness impairment in any population, is vital in designing strategies to address this public health challenge. Methods: Literature mapping evidence of vision impairment was searched for on PubMed, Google Scholar, and EBSCOhost databases MEDLINE, Health Source: Nursing/Academic Edition, Health Source – Consumer Edition, CINAHL, and Academic Search Complete. Studies that were searched for included peer-reviewed and grey literature published in English from various countries in sub-Saharan Africa (SSA). Results: Only 77 studies with 191,173 participants, contributing data from 26 countries within SSA, met the inclusion criteria for the final review. The overall pooled prevalence estimate (PPE) of blindness from the selected studies was 10% (95% confidence interval [CI]: 8.0% – 11.0%). West Africa and East Africa had the highest prevalence. The identified leading causes of blindness were cataracts (46%; 95% CI: 40% – 52%), followed by glaucoma (14%; 95% CI: 11% – 18%). There was a high level of heterogeneity in most pooled estimates (I2 ˃ 80%, p < .001). Conclusion: The prevalence of blindness in SSA has increased in all four regions with most cases being avoidable. Policymakers should prioritise blindness prevention programmes, ensure enabling health systems, and provide the necessary resources towards reducing blindness in SSA.