bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validität präoperativ entnommener SARS-CoV-2-Abstriche bei Kindern
Authors: Zaubitzer Lena , Ludwig Sonja , Jungbauer Frederic , Walter Beatrice , Lange Bettina , Rotter Nicole , Schell Angela 
Published: May 2021

Zusammenfassung
Hintergrund Aufgrund der eingeschränkten Compliance ist bei Kindern die technisch korrekte Entnahme eines gepoolten Nasopharyngealabstrichs deutlich erschwert. Vor allem bei Operationen im Bereich der oberen Atemwege besteht für alle im Operationssaal Anwesenden infolge der intraoperativen Aerosolbildung ein deutlich erhöhtes Infektionsrisiko für eine Erkrankung an COVID-19. Ziel der Studie ist die Analyse der Validität präoperativ unter im Einzelfall suboptimalen Bedingungen entnommener SARS-CoV-2-Abstriche bei Kindern.
Material und Methoden Retrospektiver Vergleich der PCR-Ergebnisse von präoperativ und intraoperativ abgenommenen SARS-CoV-2-Abstrichen bei 62 Kindern im Zeitraum April – Juli 2020. Das Alter der Kinder lag zwischen einem und 14 Jahren (Median 4,49 Jahre). Insgesamt 56 der 62 untersuchten Operationen wurden hinsichtlich des erhöhten Infektionsrisikos als Risikoeingriffe gewertet. Die PCR-Diagnostik erfolgte 1–2 Tage (bei Notfalleingriffen am selben Tag) präoperativ sowie erneut intraoperativ mittels gepooltem Nasopharyngealabstrich.
Ergebnisse Alle 62 präoperativ abgenommenen Abstriche waren negativ. Abweichend vom präoperativen Testergebnis war ein intraoperativ gewonnener Abstrich positiv.
Schlussfolgerungen Aufgrund eingeschränkter Compliance kann bei Kindern nicht immer von einer korrekten präoperativen Abstrichtechnik (Präanalytik) ausgegangen werden. Infolgedessen sind die Testergebnisse im Hinblick auf eine mögliche SARS-CoV-2-Infektion womöglich inkorrekt. Ausreichende Schutzmaßnahmen für alle im Operationssaal Anwesenden sind daher zwingend erforderlich. Zum Schutz des Personals und zur Prävention möglicher Infektionsketten perioperativ erscheint in dieser Altersgruppe trotz der guten Reproduzierbarkeit der präoperativen Abstrichergebnisse eine erneute intraoperative Testung erwägenswert, falls der präoperative Abstrich unter erschwerten Bedingungen erfolgte oder eine umfassende Anamnese, z. B. vor Notfalleingriffen oder bei Sprachbarriere, nicht möglich ist.
Triarylpyrazole Derivatives as Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation “Pyrazole Derivatives as Anticancer Agent”
Authors: Sameem Bilqees , Moghadam Ebrahim Saeedian , Darabi Majid , Shahsavari Zahra , Amini Mohsen 
Published: May 2021

Abstract
Background During the last recent years, several anti-cancer agents were introduced for the treatment of diverse kinds of cancer. Despite their potential in the treatment of cancer, drug resistance and adverse toxicity such as peripheral neuropathy are some of the negative criteria of anti-cancer agents and for this reason, the design and synthesis of new anti-cancer agents are important.
Objective Design, synthesis, and anticancer activity evaluation of some pyrazole derivatives.
Methods A series of Target compounds were prepared using multistep synthesis. Their cytotoxic activity against three different human cancer cell lines namely human colon carcinoma cells (HT-29), epithelial carcinoma cells (U-87MG), pancreatic cancerous cells (Panc-1) as well as AGO1522 normal cell line using in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was investigated.
Results 1,3-Diaryl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole and 1,3-Diaryl-5-(3,4,5-trimethoxyphenyl)- 1H-pyrazole were synthesized in good yields and their structure and purity were confirmed using 1H-NMR, 13C-NMR, and elemental analysis. Generally, the synthesized scaffolds exhibited good cytotoxicity against cancerous cell lines in comparison to the reference standard, paclitaxel. Compounds 3a and 3c, in Annexin V/ PI staining assay, exerted remarkable activity in apoptosis induction in HT-29 cell lines. Both of them also led to cell cycle arrest in the sub-G1 phase which is inconsistent with the results of apoptosis assay.
Conclusion Concerning obtained results, it is interesting to synthesis more pyrazole derivatives as anticancer agents.
Chemoselective Electrochemical Oxidation of Secondary Alcohols Using a Recyclable Chloride-Based Mediator
Authors: Cantillo David , Sommer Florian , Kappe C. Oliver 
Published: May 2021

AbstractSelective anodic oxidation of alcohols in the presence of other functional groups can be accomplished by using nitroxyl radical mediators. However, the electrochemical chemoselective oxidation of secondary alcohols in the presence of primary alcohols is an unsolved issue. Herein, we report an electrochemical procedure for the selective oxidation of secondary alcohols by using an inexpensive chloride salt that acts as a redox mediator and supporting electrolyte. The method is based on the controlled anodic generation of active chlorine species, which selectively oxidize secondary alcohols to the corresponding ketones when primary hydroxy groups are present. The method has been demonstrated for a variety of substrates. The corresponding ketones were obtained in good to excellent yields. Moreover, the chloride salt can be easily recovered by a simple extraction procedure for reuse, rendering the method highly sustainable.
A Palladium-Catalyzed Oxa-(4+4)-Cycloaddition Strategy Towards Oxazocine Scaffolds
Authors: Garrec Julian , Archambeau Alexis , Scuiller Anaïs , Liu Xueyang , Cordier Marie 
Published: May 2021

AbstractA Pd-catalyzed oxa-(4+4)-cycloaddition between 1-azadienes and (2-hydroxymethyl)allyl carbonates is described. Aurone-derived azadienes furnished polycyclic 1,5-oxazocines in good yields. Interestingly, linear azadienes have also been involved and yielded monocyclic heterocycles with complete regioselectivity. DFT calculations were carried out to gain insight on this observation.
A New Application of Gelatin Sponge in the Treatment of Hemifacial Spasm by Microvascular Decompression: A Technical Note
Authors: Chang Bowen , Tang Yinda , Wei Xiangyu , Li Shiting 
Published: May 2021

Abstract
Objectives Microvascular decompression (MVD) for facial nerve remains the highly efficient hemifacial spasm (HFS) treatment. Nonetheless, a variety of cases have poor response to MVD. Using Teflon plus gelatin sponge in MVD seems to be a good solution. No existing study has examined the efficacy of using Teflon combined with gelatin sponge during MVD for HFS. Therefore, this study aimed to compare the efficacy of Teflon combined with gelatin sponge in HFS patients relative to that of Teflon alone.
Patients and Methods We retrospectively compared the follow-up results of patients treated with Teflon and gelatin sponge with those treated with Teflon alone previously. Six hundred and eighty-eight primary HFS patients undergoing surgery from January 2010 to January 2018 were retrospectively analyzed. Three hundred and forty-seven cases received simple Teflon, while 342 cases underwent Teflon combined with gelatin sponge.
Results In the Teflon plus gelatin sponge group, the incidences of facial palsy and hearing loss at 1 day, 1 year, and 2 years following surgery was significantly lower than those in the simple Teflon group. Differences in the success rates between Teflon plus gelatin sponge and the simple Teflon group were not statistically significant at 1 day, 1 year, and 2 years after surgery. The recurrence rate in the Teflon plus gelatin sponge group was significantly lower at 2 years.
Conclusion For HFS patients undergoing MVD, using Teflon plus gelatin sponge can remarkably reduce the incidence of recurrence, facial palsy, and hearing loss compared with those using Teflon alone.
Cervical and Thoracic Spondylotic Myelopathies
Authors: Onofrei Ligia V. , Henrie A. Michael 
Published: May 2021

AbstractSpondylotic myelopathies are among the most common disorders of the spine, yet the clinical and treatment approach is far from standardized. This article discusses our current understanding of the epidemiology, pathophysiology, clinical assessment, natural history, and treatment options in degenerative myelopathies of the cervical and thoracic spine. We additionally review diagnostic modalities including imaging modalities of the spine and neurophysiological tools such as electromyography/nerve conduction studies, somatosensory-evoked potentials, and motor-evoked potentials. Assessment instruments that can be used for the assessment of myelopathies are reviewed, including the Japanese Orthopedic Association (JOA) score, modified-JOA scale, Nurick scale, nine-hole peg test, and 30-m walking test. We also review common disorders that mimic spondylotic myelopathies, as well as helpful diagnostic clues in differentiating spondylotic and nonspondylotic myelopathies.
Role of EGFR and HER-2/NEU Expression in Gall Bladder Carcinoma (GBC)
Authors: Das Chhanda , Mukhopadhyay Madhumita , Subba Srijana , Saha Ashis Kumar , Mukhopadhyay Biswanath 
Published: May 2021

Abstract
Background Gall bladder carcinoma (GBC) is the most common malignancy of the biliary tract. Being known for its geographical and racial variations, and compared with the global statistics, its incidence is higher in the Indian subcontinent, mainly in the northern and eastern regions, accounting for 80 to 95% of cases.
Aims and Objectives This study was conducted to evaluate the clinic-pathological spectrum and expression of EGFR and HER-2/NEU in GBCs and to understand their relation to prognosis, paving the way for targeted therapies for better treatment outcomes and patient survival.
Materials and Methods This is a prospective study performed in a tertiary care hospital in 30 resected specimens of GBC cases recorded in our Department of Pathology from November 2017 to November 2019. Clinical history including the radiological reports and demographic parameters were included in the study pro forma. Immunohistochemical (IHC) staining for EGFR and HER-2/NEU was performed on all the selected cases. Clinicopathologic parameters like age, sex, histologic type, perineural, and lymphovascular invasion were compared and correlated with EGFR and HER-2/NEU status.
Results Expression of EGFR was found in 93.33% of cases, which showed a highly significant correlation with histological tumor type (p = 0.000). HER-2/NEU expression was found in 56.66% of cases, which also showed a significant correlation with histological tumour type (p = 0.021). We found most of the cases with strong EGFR immunoreactivity (3+) were poorly differentiated tumors and most of the cases showing weak immunoreactivity for EGFR (1+) were well-differentiated. Conversely, in case of HER-2/NEU immunoreactivity, strong staining (3+) was seen in well-differentiated tumors and weak staining (1+) in poorly differentiated tumors. A significant correlation was also found between EGFR and HER-2/NEU expression (p = 0.000) and between cholelithiasis and EGFR expression (p = 0.033).

Conclusion EGFR is expressed in most cases of GBC. Its expression is more in poorly differentiated carcinomas as compared to the well-differentiated carcinomas, whereas HER-2/NEU expression is more in well-differentiated carcinomas. Therefore, they may serve as independent prognostic factors and also as targets for molecular therapy in GBCs.
A Fatal and Rare Case of Hydatid Cyst in the Pouch of Douglas
Authors: Asnani Ritu , Yeshvanth Sunil Kumar , Lobo Lancelot , Sonkusare Shipra 
Published: May 2021

Abstract
Hydatid cyst is a zoonotic infection and a significant public health problem in low- and middle-income countries. A 79-year-old female patient was presented to the gynecology outpatient department with complaints of pain in the abdomen and difficulty in micturition, with a mass palpable per speculum. The ultrasound was suggestive of an ovarian cystadenocarcinoma, whereas computed tomography of the abdomen favored hydatid cyst with adnexal neoplasm as a differential diagnosis. Considering the contradictory findings, a frozen section was sent to confirm the diagnosis, which showed hooklets of Echinococcus granulosus/hydatid cyst under the microscope. This was a rare case of pelvic hydatid cyst mimicking ovarian malignancy and was associated with a less-preferred mode of investigation (frozen section). This article focuses on how a frozen section, despite its limitations and being expensive, can still be considered for accurate patient management.
A Retrospective Comparative Functional and Aesthetic Outcome Study of Muscle versus Cutaneous Free Flaps for Distal Upper Extremity Reconstruction
Authors: Thomas Benjamin , Warszawski Jan , Falkner Florian , Nagel Sarah S. , Vollbach Felix , Gazyakan Emre , Schmidt Volker J. , Kneser Ulrich , Bigdeli Amir K. 
Published: May 2021

Abstract
Background Function and cosmesis are crucial in upper extremity reconstruction. Yet, there persists a lack of outcome evaluations, particularly regarding differences between free flap types.
Methods In a single-center retrospective analysis, outcomes were compared between patients with cutaneous or muscle free flaps for distal upper extremity reconstruction between 2008 and 2018. The Disabilities of Arm, Shoulder and Hand -Score, Michigan-Hand (MHQ), and Short Form 36 Health Survey (SF-36) Questionnaires were assessed, motor function was quantified, and self-reported measures of cosmesis were compared, including the Vancouver Scar-Scale (VSS), MHQ aesthetics-subscale (MAS), and Moscona's cosmetic validation-score (CVS).
Results One-hundred forty-one cases were identified, with a shift toward cutaneous flaps over the study period. Muscle flaps were used for larger defects (251 vs. 142 cm2, p = 0.008). Losses, thromboses, and donor-site complications were equally distributed. Partial necroses were more frequent in muscle flaps (11 vs. 1%, p = 0.015). Seventy patients with 53 cutaneous versus 17 muscle flaps were reexamined. There was no difference in the timing of flap coverage (after 16 vs. 15 days, p = 0.79), number of preceding (2 vs. 1.7, p = 0.95), or subsequent operations (19/53 vs. 5/17, p = 0.77). Patients with cutaneous flaps showed higher grip strength (25 vs. 17 kg, p = 0.046) and reported better hand function (MHQ: 58 vs. 47, p = 0.044) and general health (SF-36: 70 vs. 61, p = 0.040), as well as more favorable appearance (MAS: 71 vs. 57, p = 0.044, CVS: 77 vs. 72, p = 0.048), and scar burden (VSS: 0 vs. 3, p < 0.001).
Conclusion Cutaneous flaps yielded better motor function, self-perceived cosmesis, patient satisfaction, and quality of life in our cohort of distal upper extremity reconstructions.
Multimode semiconductor laser gyroscope and factors determining its operation
Authors: Sakharov V.K. 
Published: May 2021

Abstract
We report the results of a study of a multimode semiconductor laser gyroscope (MSLG) with a long fibre-optic ring cavity (RC) and alternating frequency dithering formed by a lithium niobate phase modulator, and discuss the factors that determine the device operation. The fundamental limitations in MSLG operation are phase fluctuations and the multimode nature of radiation. Phase fluctuations caused by spontaneous emission of photons in a semiconductor optical amplifier (SOA) result in a slow drop in the beat amplitude. However, its complete decay does not occur due to the periodic and short-term lock-in phenomenon, which leads to the equalisation of the fluctuation levels in pairs of counterpropagating waves (PCPWs) that form the RC modes, and, thereby, to the restoration of the beat amplitude. The limitations associated with the multimode lasing regime are overcome due to the fact that the emission spectrum consists of a small number of narrow lines, and the positions of the antinodes and nodes of standing waves in the SOA field distribution coincide or are close. Both factors lead to the mode locking in spectral lines and, as a consequence, to synchronisation of PCPW beats at the device output. The mechanism of the formation of these factors is not yet clear.
Implementation of one-qubit quantum gates with individual addressing of two rubidium atoms in two optical dipole traps
Authors: Beterov I.I. , Yakshina E.A. , Tretyakov D.B. , Entin V.M. , Al’yanova N.V. , Mityanin K.Yu. , Faruk A.M. , Ryabtsev I.I. 
Published: May 2021

Abstract
We report the results of experiments on implementing individually addressable one-qubit quantum gates on a microwave transition with two 87Rb atoms in two optical dipole traps. Addressing is carried out using additional focused laser light, which results in a differential light shift of the microwave transition frequency. In the absence of addressing in each of the atoms, Rabi oscillations are obtained on the microwave clock transition 5S1/2 (F = 2, mF
= 0) → 5S1/2(F = 1, mF
= 0) between two working levels of qubits with a frequency of up to 5.1 kHz, a contrast up to 98 %, and a coherence time up to 4 ms. When addressing is turned on, the probability of a microwave transition in the addressed atom is suppressed to an average value of less than 5 %. The Rabi oscillations remaining in the other atom have the same contrast and correspond to the implementation of individually addressable basic one-qubit quantum operations (Hadamard gate and NOT gate) from different initial states of a qubit with an average fidelity of 92% ± 3 %. After renormalising this fidelity to the error in the preparation and measurement of quantum states of qubits, an estimate of 97% ± 3% is obtained for the fidelity of individual qubit rotations.
Plasma-assisted synthesis of size-controlled monodisperse submicron gold particles using inkjet droplets
Authors: Nitta Kaishu , Shimizu Yoshiki , Terashima Kazuo , Ito Tsuyohito 
Published: May 2021

Abstract
In this study, we synthesized gold spheroidized particles with sub-micrometer diameters via atmospheric-pressure plasma-assisted processing with inkjet droplets. Microdroplets of chloroauric acid (HAuCl4) solution were generated by an inkjet device with high reproducibility and exposed to radio frequency plasma. The synthesized sub-micrometer gold particles have a very narrow size distribution (3%–9% standard deviation), and their diameters can be controlled in the 0.3–0.6 μm range by adjusting the concentration of the solution.
Multiple power-law viscoelastic relaxation in time and frequency domains with atomic force microscopy
Authors: de Sousa F B , Babu P K V , Radmacher M , Oliveira C L N , de Sousa J S 
Published: May 2021

Abstract
Complex viscoelastic materials exhibit power law (PL) relaxations, as opposed to simple materials described by exponential decays. Other interesting materials, like living cells, hold a universal double PL behavior whose exponents depend on the health and type of the cells. Usually, only dynamic assays are considered capable to study such viscoelastic relaxation mechanisms. In this work, we propose analytical responses with single or multiple power-law relaxation behavior by generalizing classical viscoelastic models in terms of fractional derivatives of arbitrary order α (0

⩽
α
⩽

1). In addition, we demonstrate that simple atomic force microscopy force curves are powerful methods to directly observe the viscoelastic relaxation of such complex materials. In order to validate our findings, we compare the viscoelastic relaxation exponents measured directly from simple force curves (SFCs) with those measured with dynamic techniques in both living cells and polyacrylamide gels. We believe the fractional models unveiled here describe a variety of complex materials and may be used (with SFCs) to explore sophisticated viscoelastic phenomena.
A super-fast optimal attitude matrix in attitude determination
Authors: Gongmin Yan , Ruotong Chen , Jun Weng 
Published: May 2021

Abstract
The fast optimal attitude matrix (FOAM) for minimizing Wahba’s loss function solves the optimal attitude matrix directly and efficiently. This method is more intuitive compared with the method of calculating attitude quaternion. A method named super-FOAM (SFOAM) is proposed with a more precise initial iteration value and a faster iterative algorithm. A condition number estimation method of third-order matrices is presented for cases without exact singular value. When the matrix condition number is not particularly large, the root-seeking formula for the quartic equation is directly used to obtain the maximum characteristic root. Otherwise, under large condition numbers, a high-accuracy estimation algorithm for the maximum eigenvalue is given to achieve a high-accuracy initial value set, which is beneficial to iteration reduction and convergence speed improvement. Finally, some comparative simulations show that the SFOAM method has the same accuracy as the singular value decomposition (Matlab) method even in the case of a very large matrix condition number, while the SFOAM’s computation is only 50%–60% of the traditional FOAM algorithm. This algorithm has good generalization and application values.
Significance of Brownian motion and thermophoresis influence on dynamics of Reiner-Rivlin fluid over a disk with non-Fourier heat flux theory and gyrotactic microorganisms: A Numerical approach
Authors: Ali Bagh , Ali Liaqat , Abdal Sohaib , Asjad Muhammad Imran 
Published: May 2021

Abstract
Bioconvection for rotational flow is conceived to provide stability to improved thermal transportation for Reiner-Rivlin nano fluid over a disk with multi-slips. The nonFourier heat flux, binary chemical reaction, magnetic force, and activation energy are incorporated. A system of nonlinear differential equations in coupled form is acquired through the fundamental relations of Reiner-Rivlin fluids. The Runge-Kutta method of fourth-order is used to solved differential equations in MATLAB environment. The impact of various parameters are discussed and drawn physically with the help of graphs. The Reiner-Rivlin fluid parameter, magnetic parameter, thermophoresis, and Brownian motion parameter escalated the nanofluid temperature field. The electromagnetic parameter and Reiner-Rivlin fluid parameter decelerated the primary flow velocity and activation energy augmented the volume fraction of nanoparticles in the boundary layer region. An excellent accord among the present and previously existing solutions is establishes the validity of the current findings.
The Comparative Analysis of Graphene Nano-based and Copper Nano-based Patched Antenna using HFSS
Authors: Atser A R , Mom J M , Igwue G A 
Published: May 2021

Abstract
Patch material plays a significant role in controlling the performance and resonating frequency of patch based antennas. In this work, we compared graphene and copper nano-based patch antennas in terms of return loss, bandwidth, gain, directivity and voltage standing wave ratio (VSWR). The simulation is carried out using high frequency structure simulator HFSS. The substrate material used is Silicon dioxide. The antenna is designed to operate in the THz frequency band of (1-15THz) with the fundamental frequency of 5.5THz. The result shows that, the classical metallic antennas with copper material resonant at lower frequency of 3THz while graphene resonant at the higher frequency of 7THz, this is due to high electrons mobility in graphene than in copper. Graphene based patch antenna achieves maximum return loss of -24.4555dB with the corresponding VSWR of 1.0413. The maximum gain of 7.1943dB is achieved with a bandwidth of 522.3GHz; this shows better antenna performance than copper except the bandwidth. The contemporary copper antenna attains return loss of -14.7028dB with the corresponding VSWR of 3.2336. The gain of 4.6219dB is achieved with a bandwidth of 1188.5GHz. With this result, it can be seen that graphene is a suitable choice and can replace copper patch material for patch antennas for wireless applications in terahertz frequency band.