bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a rapid selective high-throughput LC-MS/MS method for the determination of triclabendazole sulfoxide concentrations in sheep plasma and its use in bioequivalence studies
Authors: Farczádi Lénárd , Dósa Álmos , Melles Orsolya , Vlase Laurian 
Published: April 2021

Abstract
Triclabendazole is one of the main drugs used to treat liver fluke in livestock. A rapid LC-MS/MS method was developed and validated to determine ovine plasma levels of triclabendazole sulfoxide.
A Gemini NX-C18 column was used to achieve analytical separation, with gradient elution of a mobile phase composed of 0.1% formic acid in acetonitril and 0.1% formic acid in water at flow rate of 0.6 mL/min. MRM with positive ESI ionization was used for the detection of triclabendazole sulfoxide (m/z 360.10 from m/z 376.97). Fenbendazole was used as internal standard. Plasma protein precipitation with acetonitrile was used for sample processing.
The method was validated with regards to selectivity, linearity (r > 0.9939), within run and between run precision (CV < 8.9%) and accuracy (bias < 8.9%) over the concentration range 1–100 µg/mL plasma.
The method developed is simple, selective and can be applied in bioequivalence and bioavailability studies.
Intensity and duration of phases of wound healing after surgical intervention in сases of spontaneous periodontitis accompanied by various reactivity of the body
Authors: Yarov Yuriy 
Published: April 2021

The usage of the principle of optimal management, namely such effects on complicated forms, when the course of the disease is close to that of uncomplicated course of the disease is very promising in drug therapy of patients with generalized periodontitis.
The aim is to study the intensity and duration of the phases of wound healing of the mucosa after spontaneous periodontitis surgery accompanied by normo-, hyper- and hyporeactivity of the body by cytological examination of smear-imprints of wound exudate.
Materials and methods: The experiments were performed on 24 adult mongrel dogs divided into three equal groups. In the first group, drugs that disrupt the reactivity of the organism were not used (normoreactivity of the organism). In the second group, the animals were simulated a сondition of hyperreactivity, in the third group – the hyporeactivity of the organism. All the animals with spontaneous periodontitis underwent a patchwork surgery. In the period after surgery, cytological examination was performed on the 1st, 4th, 6th and 9th day of the experiment.
Results: It has been revealed that in cases of the normal reactivity of the organism the following periods of cellular reactions during the healing of the gums mucous membrane can be differentiated within the appropriate terms: the period of degenerative-inflammatory changes (1st day), active granulocyte-macrophage reaction (4th day), reparations (6th day) and the period of increase of reparative processes with a decrease in the overall cellular response (9th day).
Examination of smear-imprints after surgical treatment in animals with spontaneous periodontitis with hyper- and hyporeactivity of the body allowed to identify the same periods of cellular reactions during the healing of the gingival mucosa, as in cases of normoreaction with hyperreation.Tthe intensity and duration of the wound healing phases differed from those which are typical for normoreactivity of the body: granulocyte-macrophage reaction was more pronounced and lasted longer until the 6th day, so later only on the 9th day there were cellular signs of regeneration.
With hyporeaction, the intensity and duration of the wound healing phases differed from those which are typical for normoreactivity of the body: granulocyte reaction occurred later (only on the 6th day) and lasted longer, signs of active regeneration appeared later on the 9th day. Therefore, postoperative wound healing in animals with impaired body reactivity was delayed for 3-4 days.
Conclusions: Thus, direct medical correction with transforming intensity and duration of the phases of the wound process which are characteristic for impaired reactivity of the body into the phases which are typical for normoreaction is essential. It provides synchronization of necrotic and reparative processes and creates conditions for normal uncomplicated healing of periodontal soft tissues
Anthropometric parameters of first-year students of pedagogical specialties
Authors: Vasilieva Svetlana , Stepanenko Inna , Kravchuk Kateryna 
Published: April 2021

The topic is relevant due to a detailed study of the factors determining the health level of nowadays students, and taking these factors into consideration for the development of programs to strengthen their health. Since the scientific literary data on the physical development of student youth is somewhat contradictory, namely the morphological and functional indicators of a person depends on the level of physical health and adaptive capacity, it has been decided to determine the freshmen’s anthropometric parameters.
The aim of the study was to take anthropometric measurements of total and comprehensive body size of 105 students studying at Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, assess their compliance with anthropometric standards, determine the somatotype and foot shape in order to create a database for further monitoring of physical development and identify patterns of anthropometric indicators under conditions of modern learning technologies.
Research methods. Anthropometric measurements were taken according to standard anthropometric methods suggested by V. V. Bunak [1]. Data estimation was performed by the method of centile intervals and indices. The foot shape was assessed by the plantogram based on the Chyzhyn index. The obtained data were statistically processed according to the STATISTICA 5.5 program.
Research results. The peculiarities of anthropometric parameters and somatotype of Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University first-year students are established: height, body weight; girth sizes: chest, waist, hips; body mass index, Kettle mass-growth index, body harmony indices, foot shape
The dual form of education as a component of integration processes in the educational environment
Authors: Kravchenko Olha 
Published: April 2021

The most important characteristic feature of the current stage of development of higher education in Ukraine is integration processes that reflect, on the one hand, substantive and structural changes within the education system, and on the other hand, the processes of interaction between education and the production sphere. The priorities of state policy and the concept of innovative development in the field of education indicate the necessity to form a wide range of mechanisms for cooperation between business and educational institutions. In the educational standard of higher education in specialty it is noted that the future specialist must be ready for the following activities: production and technological activities, project activities, research activities, organizational and management activities. Specific types of professional activity, for which a specialist is mainly prepared, are determined by higher educational institutions in cooperation with students, teachers, and employers' associations. With such an essential range of requirements for future specialists, there is a need for qualitative changes in the content and organization of training.
In modern social and economic conditions, the activities of higher education institutions that train specialists for the food industry are associated with solving a number of problems: the imperfection of the mechanisms of social partnership between educational institutions and employers; insufficient practical orientation in the training of qualified personnel for a particular enterprise; inconsistency of the educational and resource base of educational institutions. As a result of the search for effective forms of organizing of the educational process for solving the tasks set before education, the introduction of elements of dual education in the educational process seems to be expedient, promising, and of current interest
TRANSFORMING THE CHARACTER OF THE UPPER MISSISSIPPI RIVER
Authors: COCKERILL KRISTAN 
Published: April 2021

ABSTRACT
Despite the long-understood variability in the Mississippi River, the upper portions of the river have historically received less attention than the lower reach and this culminated in the lower river dominating twentieth century river management efforts. Since the seventeenth century, there have been multiple tendencies in how the upper river was characterized, including relatively spare notes about basic conditions such as channel width and flow rates which shifted to an emphasis on romantic descriptions of the riparian scenery by the mid-nineteenth century. Finally, by the late nineteenth century the upper river was routinely portrayed as a flawed entity requiring human intervention to fix it. While the tone and specific language changed over time, there remained a consistent emphasis that whatever was being reported about the river was scientifically accurate.
MORE THAN JUST A ROCK COLLECTION. THE METEORITE COLLECTION OF THE ITALIAN GEOLOGIST TEODORO MONTICELLI (1759–1845)
Authors: FRANZA ANNARITA , PETTI CARMELA , PRATESI GIOVANNI 
Published: April 2021

ABSTRACT
This paper is focused on the meteorite collection that belonged to the Italian naturalist and geologist Teodoro Monticelli (1759–1845). Today he is mainly remembered as both the author of books and essays on the volcanic activity of Mount Vesuvius and as the owner of a mineralogical cabinet of more than 16,000 specimens. Monticelli’s scientific activity as a meteorite collector is, however, largely forgotten. This contribution presents for the first time the meteorite collection that belonged to Teodoro Monticelli and is now preserved at the Royal Mineralogical Museum of Naples. We reconstruct the history of the collection and argue that it represents an exceptional example of historical heritage. We also highlight the potential of the collection as a scientific research tool.
CLEMENTINE HELM BEYRICH (1825–1896), THE UNUSUAL CASE OF A WOMAN POPULARIZER OF THE GEOSCIENCES DURING THE NINETEENTH CENTURY IN CENTRAL EUROPE
Authors: MOHR BARBARA A. R. 
Published: April 2021

ABSTRACT
During the nineteenth century the role of women was very much restricted. In the geosciences, women were not able to study and thus even less able to publish. Here the work of one female writer is presented who, due to her upbringing in an intellectual family with close connections to the most celebrated scientists in Prussia/Germany, such as Alexander von Humboldt, the mineralogist Christian Samuel Weiss, Ernst Haeckel and many others, was aware of scientific progress and the discussions of the times. Based on her unusual education by teachers and scientists and her intellectual abilities, and knowledge acquired through marriage to a well-established geoscientist, she wrote popular juvenile literature that included geological and palaeontological content. This scientific content was typically woven into fairy tales or novels for adolescent girls and served as a way to spread geoscientific knowledge to a large audience.
Global Commodities
Authors: Landsteiner Erich , Langthaler Ernst 
Published: April 2021

Focusing on coca, coffee, gold, soy, sugar, and tea, articles in a special issue of the Austrian Journal of Historical Studies 30/3 (2019) on Global Commodities aim at tracing the emergence of commodity chains through the expansion and contraction of commodity frontiers. Frontier shifts imply complex – and potentially conflicting – interactions shaped by as well as shaping socio-natural systems. Thus, the contributions reveal commodity chains and their frontiers to be subject to negotiations between multiple actors, both human and non-human. Each of the contributions concentrates on one or more world region(s) of frontier shifts, while taking into account the transregional, transnational, and transcontinental connections via commodity chains. Thereby, these commodity-focused histories reveal the benefit of combining global with regional or even local perspectives (Joseph, 2019).
Angular changes of impacted mandibular third molars and developing mandibular third molars in premolar extraction cases- A retrospective radiographic study
Authors: Velachery Shanthi , Backer Shahir , Shetty Sandeep , Parveen Katheesa , Shetty Nandish Kumar , Husain Akhter 
Published: April 2021

Successful eruption of impacted third molars requires the establishment of proper mesio-distal angulation as the tooth erupts into the oral cavity. Extraction of premolars in orthodontic cases may favour the eruption of third molars.Patients were divided into 2 categories. Category I - Radiographs of patients undergone orthodontic treatment with third molar roots formation completed and category II - Radiographs of patients undergone orthodontic treatment with third molar roots formation uncompleted. The samples consisted of 24 third molars in each category with a total of 48 samples. On pre operative and post operative OPGs linear and angular measurements were measured. : There was statistically significant difference in the space between the anterior border of the ramus and the second molar. But there was no significant difference in the angulation of the third molars. So even if there is a gain of space for the third molars to erupt, the changes in the angulations of third molar does not favour the spontaneous eruption after the orthodontic treatment with extraction of 1 premolar.Extraction of 1 premolar has positive influence on the space available for the third molar eruption. But there are no changes in the angulations of the third molars that would in turn help in the eruption.
Snuff dippers cancer: An enigmatic case report
Authors: Bahal Megha , Grover Gourav 
Published: April 2021

Verrucous carcinoma, a very well differentiated malignant tumour of the oral cavity which has capacity to invade the underlying tissues very quickly. Very invasive as name suggests, this tumour is warty often misleads the oral physician to come upto a clear cut diagnosis. Encountering a patient of Verrucous carcinoma is often accidental as the awe astonishing fact for this tumour is that the subject would never report the chief complaint in maximum number if cases. Verrucous hyperplasia, a very common variant or antecedent of Verrucous carcinoma has almost similar biological potential as the former. This warty appearing tumour aggravates quickly in patients who have constant habit of tobacco chewing and areca nut chewing, thus its termed as Snuff Dippers Cancer.Verrucous carcinoma (also known as Ackerman tumor) is an uncommon exophytic low-grade well-differentiated variant of squamous cell carcinoma. This neoplasm typically involves the oral cavity, larynx, genitalia, skin, and esophagus. Often the ‘bad kind’ of squamous cell carcinoma, the troubling and problematic diagnosis of this cancer makes it a physician dilemma both clinically and histopathologically.
Virtual Microscopy in Undergraduate Pathology Education
Authors: Lakhtakia Ritu 
Published: April 2021

Objectives: Whole-slide imaging (WSI) and virtual microscopy (VM) have revolutionized teaching, diagnosis and research in histopathology. The aims of this study were to establish the feasibility of achieving early integration of clinical reasoning with undergraduate pathology teaching on a virtual microscopy platform and, to determine its student-centricity through student feedback. Methods: Thirty-eight VM-centered clinical cases were introduced to forty-nine students in an integrated undergraduate medical curriculum. The cases were aligned to curricular objectives, reinforced the pathologic basis of disease with critical thinking and were delivered across fifteen interactive small-group sessions. A simulated cross-disciplinary integration and judicious choice of pertinent diagnostic investigations was linked to principles of management. Feedback was obtained through a mixed-methods approach. Results: User-friendliness, gradual learning curve of VM and annotation-capacity were scored 4-5 on a Likert scale of 1-5 by 91.84%, 87.75% and 83.67% students respectively. Students agreed on content-match to the stage of learning (81.63%), theme of the week (91.84%) and development of a strong clinical foundation (77.5%). Integration (85.71%) and clinico-pathological correlation (83.67%) were strengths of this educational effort. High student attendance (~100%) and improved assessment scores on critical thinking (80%) were observed. Software lacunae included frequent logouts and lack of note-taking tools. Easy access was a significant student-centric advantage. Conclusion: A VM-centered approach with clinico-pathological correlation has been successfully introduced to inculcate integrated learning. Using the pathologic basis of disease as fulcrum and critical reasoning as anchor, a digitally-enabled generation of medical students have embraced this educational tool for tutor-guided, student-centered learning.
Keywords: virtual, digital, pathology, microscopy, medical education
Identification of Remarkable Dimensions in Management and Evaluation of Non-Communicable Disease Programmes
Authors: Vali Leila , Ataollahi Fatemeh , Amiresmaili Mohammadreza , Nakhaee Nouzar 
Published: April 2021

Objectives: This study aimed to identify indicators of proper programme development in the field of non-communicable diseases through the systematic review of existing literature. Methods: In this systematic review, a search was conducted through PubMed, Scopus, EMBASE, Web of Science, Google Scholar, Cochrane Library, ProQuest and grey literature. The search was limited to literature published between January 2000 and January 2019. Results: A total of 36 articles were found relevant to the study objectives. Data were obtained through these articles based on the context, input, process and product (CIPP) model. Seven subsets for context, five subsets for input, four subsets for process and six subsets for the product were identified. Conclusion: According to CIPP subsets, indicators such as programme definition, appropriate organisational culture, structure and evaluation must be considered to develop an appropriate programme to improve health services.
Keywords: Disease Management; Program Evaluation; Health Status Indicators; Program Development.
Magnetic Resonance Imagery Findings in Androgen Insensitivity
Authors: Mukhopadhyay Indrani , Aggarwal Rohit , Mutreja Deepti , Maheswari Sujit 
Published: April 2021

Androgen insensitivity syndrome (AIS) is a sex-development disorder resulting from mutations in the androgen receptor. In its complete form, patients are genetically male but phenotypically female, presenting with primary amenorrhea. We report three cases of AIS highlighting the multifaceted role of magnetic resonance imaging (MRI) for presurgical planning by evaluating location and type of gonads and detecting complications. All patients presented at the Gynaecology Out-patient Department of Command Hospital, Bangalore, India, between 2013–2016 with primary amenorrhea and MRI accurately localised testes in all; one patient had bilateral inguinal testes; two had intraabdominal testes. Intraabdominal testes were not localised on ultrasonography. MRI also depicted Sertoli cell adenomas and Wolffian duct remnants. MRI provides comprehensive imaging before surgical treatment and can, thus, be considered a ‘one-stop shop’ for AIS imaging. All patients underwent laparoscopic gonadectomy which is the standard of care, with preoperative counselling about fertility. Postoperatively, they were started on oestrogen therapy.
Keywords: Amenorrhea; Androgen Insensitivity Syndrome; Magnetic Resonance Imaging; Case Report; India.
A Brief Analysis and Suggestions on the Current Situation of New Energy Vehicles in China
Authors: Guan Tianzuo 
Published: April 2021

With continuous development of China’s economy in the past two decades, people’s living conditions have been greatly improved. The improved living quality boosts the prosperity of the automobile industry in China. However, whilst the popularity of automobiles promotes the rapid development of social economy and modern civilization, it also brings severe energy and environmental problems.
The government pays great attention to these problems, and promotes the development of new energy vehicle industry by issuing various policies and encouraging consumers to actively buy new energy vehicles. However, under these policy incentives and economic incentives, the domestic new energy vehicle industry did not present the expected market response.
This paper briefly describes the development status and existing problems of domestic new energy vehicle industry, and puts forward some feasible suggestions.
Research on Optimal Allocation Strategy of Bank Credit Funds Based on KMV Model and Logit Model
Authors: Liu Chao , Zhang Xiaofan , Wang Yuerong 
Published: April 2021

Using KMV model, normal Copula function, K-means cluster analysis and logit model, this paper constructs the enterprise credit risk assessment model, bank credit fund optimal allocation model, banking risk index system, and synthetically uses software such as MATLAB、SPSS to solve the problem of credit fund distribution strategy for small and medium-sized enterprises, and draws the conclusion that the loan interest rate classification of enterprise credit risk assessment, the weight of bank to credit fund distribution, and the change of bank risk index weight in sudden situation.Finally, the above model provides the strategy for bank credit fund allocation and gives the test and evaluation.
The outstanding features of this paper are: using the KMV model and the normal Copula function, combining the enterprise credit rating and default times to establish a linear model to quantify the enterprise credit risk, will not beeasy to calculate the industry violation probability quantitative analysis, also get the bank credit annual interest rate fordifferent industries and levels of enterprises, and through the representative industries of the optimal loan weight calculation, so that the bank decision has the characteristics of the least unit risk. This paper also establishes a banking risk index system with emergency factors, which is of practical significance to make decision analysis of emergency events.