bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aktuelle Möglichkeiten und Herausforderungen bei der Diagnostik des laryngopharyngealen Refluxes
Authors: Runggaldier D. , Hente J. , Brockmann-Bauser M. , Pohl D. , Bohlender J. E. 
Published: February 2021

ZusammenfassungDer laryngopharyngeale Reflux (LPR) ist definiert als ein Zurückfließen von gastralem bzw. gastroduodenalem Sekret in den Larynx- bzw. Pharynxbereich und ist durch ein sehr breites Spektrum an teils unspezifischen Symptomen wie beispielsweise chronischem Husten, zervikalem Globusgefühl oder Hypersekretion von Mukus im Larynx und Pharynx charakterisiert. Aufgrund des Fehlens eines Goldstandards und der heterogenen Studienlage gestaltet sich die Diagnosestellung des LPR jedoch weiterhin schwierig und wird in absehbarer Zeit weiterhin kontrovers diskutiert werden. Insgesamt kann man jedoch davon ausgehen, dass bei suggestiver Anamnese mit erhöhten Scores im Reflux Symptom Index (RSI), entsprechenden endoskopischen Befunden mit pathologischem Reflux Finding Score (RFS) und auffälliger ösophagealer oder oropharyngealer 24-h-pH-Metrie ohne Hinweise auf eine andere Grunderkrankung die Diagnose eines LRP wahrscheinlich ist. In der vorliegenden Übersichtsarbeit sollen die genannten Methoden ebenso wie neuere Werkzeuge bei der Diagnose des LPR kritisch diskutiert werden.
Subakutes Nierenversagen bei einer 40-jährigen nordafrikanischen Patientin
Authors: Chahoud-Schriefer T. , Wiech T. , Schäfer G. , Harendza S. 
Published: February 2021

ZusammenfassungEine 40-jährige Patientin aus Eritrea stellte sich zur Abklärung einer unklaren progredienten Niereninsuffizienz vor. Die konservative Diagnostik war nicht wegweisend. Die Nierenbiopsie zeigte eine interstitielle Nephritis, deren Genese sich aufgrund einer leeren Medikamentenanamnese nicht zuordnen ließ. Im Rahmen der Abklärung ergab sich ein Rezidiv der bereits 2015 therapierten Urogenitaltuberkulose. Bei Vorliegen einer interstitiellen Nephritis sollte neben einer Medikamentenanamnese auch an eine Genese im Rahmen von systemischen Infektionen oder Systemerkrankungen gedacht werden.
Comorbid physical illnesses in adult outpatients with psychotic disorders: risk factors, psychological functioning, and quality of life outcomes
Authors: Teh Wen Lin , Cetty Laxman , Jeyagurunathan Anitha , Devi Fiona , Roystonn Kumarasan , Tang Charmaine , Verma Swapna , Subramaniam Mythily 
Published: February 2021

Abstract
Purpose
In contrast to global research, where physical comorbidity in psychotic disorders is established, only a few studies have been conducted in Southeast Asia. With a concerning trend of chronic physical illnesses emerging in adults below the age of 65, an investigation into comorbid chronic physical illnesses in adults diagnosed with psychotic disorders is necessary. This study aims to explore the risk factors, psychological functioning, and quality of life outcomes associated with comorbidity in adults below the age of 65, diagnosed with psychotic disorders, in a multi-ethnic non-Western setting.

Methods
Electronic medical records of 364 patients with psychotic disorders who had provided written consent to participate were screened for co-occurring physical conditions. The majority of participants were female (53.7%), Chinese (69%), single (74.5%), and had tertiary and above education (43%). They were approximately 35 years old on average and the mean age of onset for psychosis was 26.7 years old.

Results
Comorbid physical illnesses were present in approximately a third of adults with psychotic disorders (28%). They typically reported cardiovascular-related diseases, respiratory, and skin conditions. Comorbidity was significantly related to lower physical quality of life. As compared to other types of psychotic disorders, schizophrenia was significantly related to a greater frequency of comorbid physical conditions. Multinomial regression analyses revealed that age, age of onset, Malay and Indian ethnicities were significant factors.

Conclusion
Physical comorbidity in adults below the age of 65 is common, signifying an emerging need to place greater attention into the screening and emphasis on the physical care needs of this age group. Finally, more research is needed to understand the impact of common co-occurring acute and chronic cardiovascular, skin, and respiratory diseases locally.
A comparison of optimization solvers for log binomial regression including conic programming
Authors: Schwendinger Florian , Grün Bettina , Hornik Kurt 
Published: February 2021

AbstractRelative risks are estimated to assess associations and effects due to their ease of interpretability, e.g., in epidemiological studies. Fitting log-binomial regression models allows to use the estimated regression coefficients to directly infer the relative risks. The estimation of these models, however, is complicated because of the constraints which have to be imposed on the parameter space. In this paper we systematically compare different optimization algorithms to obtain the maximum likelihood estimates for the regression coefficients in log-binomial regression. We first establish under which conditions the maximum likelihood estimates are guaranteed to be finite and unique, which allows to identify and exclude problematic cases. In simulation studies using artificial data we compare the performance of different optimizers including solvers based on the augmented Lagrangian method, interior-point methods including a conic optimizer, majorize-minimize algorithms, iteratively reweighted least squares and expectation-maximization algorithm variants. We demonstrate that conic optimizers emerge as the preferred choice due to their reliability, lack of requirement to tune hyperparameters and speed.
Integrity investigation of global ionospheric TEC maps for high-precision positioning
Authors: Zhao Jiaojiao , Hernández-Pajares Manuel , Li Zishen , Wang Ningbo , Yuan Hong 
Published: February 2021

AbstractAside from the ionospheric total electron content (TEC) information, root-mean-square (RMS) maps are also provided as the standard deviations of the corresponding TEC errors in global ionospheric maps (GIMs). As the RMS maps are commonly used as the accuracy indicator of GIMs to optimize the stochastic model of precise point positioning algorithms, it is of crucial importance to investigate the reliability of RMS maps involved in GIMs of different Ionospheric Associated Analysis Centers (IAACs) of the International GNSS Service (IGS), i.e., the integrity of GIMs. We indirectly analyzed the reliability of RMS maps by comparing the actual error of the differential STEC (dSTEC) with the RMS of the dSTEC derived from the RMS maps. With this method, the integrity of seven rapid IGS GIMs (UQRG, CORG, JPRG, WHRG, EHRG, EMRG, and IGRG) and six final GIMs (UPCG, CODG, JPLG, WHUG, ESAG and IGSG) was examined under the maximum and minimum solar activity conditions as well as the geomagnetic storm period. The results reveal that the reliability of the RMS maps is significantly different for the GIMs from different IAACs. Among these GIMs, the values in the RMS maps of UQRG are large, which can be used as ionospheric protection level, while the RMS values in EHRG and ESAG are significantly lower than the realistic RMS. The rapid and final GIMs from CODE, JPL and WHU provide quite reasonable RMS maps. The bounding performance of RMS maps can be influenced by the location of the stations, while the influence of solar activity and the geomagnetic storm is not obvious.
Forensisch-medizinische Untersuchungen von Tatverdächtigen. Eine Analyse von 270 Gutachten aus den Jahren 2006 bis 2018
Authors: Zack F. , Bernhardt S. , Arnold C. , Büttner A. 
Published: February 2021

Zusammenfassung
Hintergrund
Zu den Aufgaben in der rechtsmedizinischen Praxis gehören zunehmend forensisch-medizinische Untersuchungen von Lebenden. Im Gegensatz zu Studien über Gewaltopfer findet sich in der Fachliteratur allerdings ein erhebliches Defizit an Ergebnissen über systematische rechtsmedizinische Untersuchungen von Tatverdächtigen.

Fragestellung
Welche relevanten Daten können aus einer retrospektiven Analyse von forensisch-medizinischen Untersuchungen von Tatverdächtigen erhoben und welche Rückschlüsse für die rechtsmedizinische Praxis gezogen werden?

Material und Methode
Es wurden insgesamt 270 Gutachten nach forensisch-medizinischen Untersuchungen von Tatverdächtigen aus dem Einzugsgebiet des Instituts für Rechtsmedizin der Universitätsmedizin Rostock der Jahre 2006 bis 2018 nach vorab definierten Kriterien ausgewertet.

Ergebnisse
Die vorgeworfenen Straftaten waren am häufigsten Körperverletzungen (n = 88 = 30,7 %), gefolgt von vorsätzlichen Tötungen (n = 63 = 22,0 %) und Sexualdelikten (n = 49 = 17,1 %). Von den begutachteten Personen waren 236 (87,4 %) männlich und 34 (12,6 %) weiblich. Die Mehrzahl der Tatverdächtigen (n = 175 = 65,5 %) war in einem Lebensalter von 18 bis 40 Jahren.
Im Hinblick auf die Aussage der rechtsmedizinischen Ergebnisse in Bezug auf den vorgeworfenen Straftatbestand wurden 126 (46,7 %) Gutachten als für den Tatverdächtigen belastend, 13 (4,8 %) als entlastend und 131 (48,5 %) als frei von Be- oder Entlastungsaussagen eingestuft.
Zu den 270 Gutachten über Tatverdächtige gab es 209 (77,4 %) korrespondierende Opferuntersuchungen. Von diesem Teilkollektiv mit Täter-Opfer-Begutachtungen wurden in 193 Fällen (92,3 %) Tatverdächtige und Opfer von demselben Gutachter untersucht.

Schlussfolgerungen
Für die Rekonstruktion eines Tatgeschehens sind rechtsmedizinische Untersuchungen des Opfers und des Tatverdächtigen wertvoller als die nicht selten beobachtete Untersuchung der geschädigten Person allein. Befunde mit belastenden Tendenzen für den Tatverdächtigen werden häufiger festgestellt als solche, die zu einer Entlastung des Beschuldigten führen. Da es in der Fachliteratur im Vergleich zu den Opfern von Gewalttaten ein Defizit an Ergebnissen über systematische forensisch-medizinische Untersuchungen von Tatverdächtigen gibt, sollten weitere Studien folgen.
Degradation of the low-calorie sugar substitute 5-ketofructose by different bacteria
Authors: Schiessl Jacqueline , Kosciow Konrad , Garschagen Laura S. , Hoffmann Juliane J. , Heymuth Julia , Franke Thomas , Deppenmeier Uwe 
Published: February 2021

Abstract
There is an increasing public awareness about the danger of dietary sugars with respect to their caloric contribution to the diet and the rise of overweight throughout the world. Therefore, low-calorie sugar substitutes are of high interest to replace sugar in foods and beverages. A promising alternative to natural sugars and artificial sweeteners is the fructose derivative 5-keto-D-fructose (5-KF), which is produced by several Gluconobacter species. A prerequisite before 5-KF can be used as a sweetener is to test whether the compound is degradable by microorganisms and whether it is metabolized by the human microbiota. We identified different environmental bacteria (Tatumella morbirosei, Gluconobacter japonicus LMG 26773, Gluconobacter japonicus LMG 1281, and Clostridium pasteurianum) that were able to grow with 5-KF as a substrate. Furthermore, Gluconobacter oxydans 621H could use 5-KF as a carbon and energy source in the stationary growth phase. The enzymes involved in the utilization of 5-KF were heterologously overproduced in Escherichia coli, purified and characterized. The enzymes were referred to as 5-KF reductases and belong to three unrelated enzymatic classes with highly different amino acid sequences, activities, and structural properties. Furthermore, we could show that 15 members of the most common and abundant intestinal bacteria cannot degrade 5-KF, indicating that this sugar derivative is not a suitable growth substrate for prokaryotes in the human intestine.

Key points
• Some environmental bacteria are able to use 5-KF as an energy and carbon source.
• Four 5-KF reductases were identified, belonging to three different protein families.
• Many gut bacteria cannot degrade 5-KF.
Estimation of the feeding record of pregnant Antarctic minke whales (Balaenoptera bonaerensis) using carbon and nitrogen stable isotope analysis of baleen plates
Authors: Uchida Mayuka , Suzuki Ippei , Ito Keizo , Ishizuka Mayumi , Ikenaka Yoshinori , Nakayama Shouta M. M. , Tamura Tsutomu , Konishi Kenji , Bando Takeharu , Mitani Yoko 
Published: February 2021

AbstractAntarctic minke whales (Balaenoptera bonaerensis) are migratory capital breeders that experience intensive summer feeding on Antarctic krill (Euphausia superba) in the Southern Ocean and winter breeding at lower latitudes, but their prey outside of the Antarctic is unknown. Stable isotope analyses were conducted on δ13C and δ15N from the baleen plates of ten pregnant Antarctic minke whales to understand the growth rate of the baleen plate and their diet in lower latitudes. Two to three oscillations along the length of the edge of the baleen plate were observed in δ15N, and the annual growth rate was estimated to be 75.2 ± 20.4 mm, with a small amplitude (0.97 ± 0.21 ‰). Bayesian stable isotope mixing models were used to understand the dominant prey that contributed to the isotopic component of the baleen plate using Antarctic krill from the stomach contents and reported values of Antarctic coastal krill (Euphausia crystallorophias), Antarctic silver fish (Pleuragramma antarcticum), Australian krill spp., and Australian pelagic fish spp.. The models showed that the diet composition of the most recent three records from the base of the baleen plates (model 1) and the highest δ15N values in each baleen plate (model 2) were predominantly Antarctic krill, with a contribution rate of approximately 80%. The rates were approximately 10% for Antarctic coastal krill and less than 2.0% for the two Australian prey groups in both models. These results suggest that pregnant Antarctic minke whales did not feed on enough prey outside of the Antarctic to change the stable isotope values in their baleen plates.
Correlation between peri-operative complication in middle ear cholesteatoma surgery using STAMCO, ChOLE, and SAMEO-ATO classifications
Authors: Cacco Tommaso , Africano Stefano , Gaglio Gilda , Carmisciano Luca , Piccirillo Enrico , Castello Eolo , Peretti Giorgio 
Published: February 2021

Abstract
Purpose
To compare the relationship between the variable “complication” and the other variables of middle ear cholesteatoma classifications (STAMCO, ChOLE, and SAMEO-ATO).

Methods
Retrospective study of 110 patients that underwent 132 middle ear surgeries between the 1 January 2012 and the 31 December 2019 for chronic otitis with cholesteatoma classified according to STAMCO, ChOLE, and SAMEO-ATO classifications in a tertiary health care centre.

Results
Older age, male gender, STAMCO-T, and SAMEO-ATO [O1, T, O2, (s -)] and mastoid involvement (STAMCO-M and ChOLE-Ch) were associated with an increased risk of complication report.

Conclusions
In our series, statistical analysis pointed out a relationship between surgical complications and age, gender, site, mastoidectomy type, and ossicular chain status at surgery. The choice of variables to be recorded for cholesteatoma staging should be carefully balanced, considering that “complication” variable could be a repetitive item.
Using a cochlear implant processor as contralateral routing of signals device in unilateral cochlear implant recipients
Authors: Gawliczek Tom , Guignard Jérémie , Schmid Christoph , Wimmer Wilhelm , Caversaccio Marco , Kompis Martin , Weder Stefan 
Published: February 2021

Abstract
Purpose
In unilateral cochlear implant (CI) recipients, a contralateral routing of signals (CROS) device enables to receive auditory information from the unaided side. This study investigates the feasibility as well as subjective and objective benefits of using a CI processor as a CROS device in unilateral CI recipients.

Methods
This is a single-center, prospective cohort study. First, we tested the directionality of the CROS processor in an acoustic chamber. Second, we examined the difference of speech perception in quiet and in noise in ten unilateral CI recipients with and without the CROS processor. Third, subjective ratings with the CROS processor were evaluated according to the Client Oriented Scale of Improvement Questionnaire.

Results
There was a time delay between the two devices of 3 ms. Connection of the CROS processor led to a summation effect of 3 dB as well as a more constant amplification along all azimuths. Speech perception in quiet showed an increased word recognition score at 50 dB (mean improvement 7%). In noise, the head shadow effect could be mitigated with significant gain in speech perception (mean improvement 8.4 dB). This advantage was reversed in unfavorable listening situations, where the CROS device considerably amplified the noise (mean:  – 4.8 dB). Subjectively, patients who did not normally wear a hearing aid on the non-CI side were satisfied with the CROS device.

Conclusions
The connection and synchronization of a CI processor as a CROS device is technically feasible and the signal processing strategies of the device can be exploited. In contra-laterally unaided patients, a subjective benefit can be achieved when wearing the CROS processor.
The influence of training status on right ventricular morphology and segmental strain in elite pre-adolescent soccer players
Authors: Unnithan Viswanath B. , Beaumont Alexander , Rowland Thomas W. , Sculthorpe Nicholas , George Keith , Lord Rachel , Oxborough David 
Published: February 2021

AbstractCardiac modifications to training are a product of the genetic pre-disposition for adaptation and the repetitive haemodynamic loads that are placed on the myocardium. Elite pre-adolescent athletes are exposed to high-intensity training at a young age with little understanding of the physiological and clinical consequences. It is unclear how right ventricular (RV) structure and function may respond to this type of stimulus. The aim of this study was to compare RV structure and strain across the cardiac cycle and within individual segments in elite soccer players (SP) and controls (CON). Methods: Twenty-two highly trained, male pre-adolescent SP and 22 age-and sex-matched recreationally active individuals CON were investigated using 2D echocardiography, including myocardial speckle tracking to assess basal, mid-wall, apical and global longitudinal strain and strain rate during systole (SRS) and diastole (SRE and SRA). Results: greater RV cavity size was identified in the SP compared to CON (RVD1 SP: 32.3 ± 3.1 vs. CON: 29.6 ± 2.8 (mm/m2)0.5; p = 0.005). No inter-group differences were noted for peak global RV strain (SP: − 28.6 ± 4.9 vs CON: − 30.3 ± 4.0%, p = 0.11). Lower mid-wall strain was demonstrated in the SP compared to CON (SP: − 27.9 ± 5.8 vs. CON: − 32.2 ± 4.4%, p = 0.007). Conclusion: Soccer training has the potential to increase RV size in pre-adolescent players. The unique segmental analyses used in this study have identified inter-group differences that were masked by global strain evaluations. The clinical and physiological implications of these findings warrant further investigation.
Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice
Authors: Perniss Alexander , Schmidt Patricia , Soultanova Aichurek , Papadakis Tamara , Dahlke Katja , Voigt Anja , Schütz Burkhard , Kummer Wolfgang , Deckmann Klaus 
Published: February 2021

AbstractCholinergic chemosensory cells (CCC) are infrequent epithelial cells with immunosensor function, positioned in mucosal epithelia preferentially near body entry sites in mammals including man. Given their adaptive capacity in response to infection and their role in combatting pathogens, we here addressed the time points of their initial emergence as well as their postnatal development from first exposure to environmental microbiota (i.e., birth) to adulthood in urethra and trachea, utilizing choline acetyltransferase (ChAT)-eGFP reporter mice, mice with genetic deletion of MyD88, toll-like receptor-2 (TLR2), TLR4, TLR2/TLR4, and germ-free mice. Appearance of CCC differs between the investigated organs. CCC of the trachea emerge during embryonic development at E18 and expand further after birth. Urethral CCC show gender diversity and appear first at P6-P10 in male and at P11-P20 in female mice. Urethrae and tracheae of MyD88- and TLR-deficient mice showed significantly fewer CCC in all four investigated deficient strains, with the effect being most prominent in the urethra. In germ-free mice, however, CCC numbers were not reduced, indicating that TLR2/4-MyD88 signaling, but not vita-PAMPs, governs CCC development. Collectively, our data show a marked postnatal expansion of CCC populations with distinct organ-specific features, including the relative impact of TLR2/4-MyD88 signaling. Strong dependency on this pathway (urethra) correlates with absence of CCC at birth and gender-specific initial development and expansion dynamics, whereas moderate dependency (trachea) coincides with presence of first CCC at E18 and sex-independent further development.
Faster algorithms for counting subgraphs in sparse graphs
Authors: Bressan Marco 
Published: February 2021

AbstractGiven a k-node pattern graph H and an n-node host graph G, the subgraph counting problem asks to compute the number of copies of H in G. In this work we address the following question: can we count the copies of H faster if G is sparse? We answer in the affirmative by introducing a novel tree-like decomposition for directed acyclic graphs, inspired by the classic tree decomposition for undirected graphs. This decomposition gives a dynamic program for counting the homomorphisms of H in G by exploiting the degeneracy of G, which allows us to beat the state-of-the-art subgraph counting algorithms when G is sparse enough. For example, we can count the induced copies of any k-node pattern H in time $$2^{O(k^2)} O(n^{0.25k + 2} \log n)$$

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(

k
2

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O

(

n

0.25
k
+
2

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)

if G has bounded degeneracy, and in time $$2^{O(k^2)} O(n^{0.625k + 2} \log n)$$

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O
(

k
2

)

O

(

n

0.625
k
+
2

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if G has bounded average degree. These bounds are instantiations of a more general result, parameterized by the degeneracy of G and the structure of H, which generalizes classic bounds on counting cliques and complete bipartite graphs. We also give lower bounds based on the Exponential Time Hypothesis, showing that our results are actually a characterization of the complexity of subgraph counting in bounded-degeneracy graphs.