bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Company Performance on Sharia Commercial Bank Executive Compensation in Indonesia
Authors: Asyari Mahfud , Maritsa Firna Hayyu Nindya 
Published: April 2021

After the disclosure of data from companies, research on executive compensation began to develop. Several studies on executive compensation in banking found that the determination of compensation is positively related to company performance. This research aims to determine the relationship between company performance and executive compensation of Islamic Commercial Bank’s in Indonesia. Company performance is proxied by Return on Assets (ROA). This study uses a sample of Islamic Commercial Banks because they have very good performance growth and currently only have a market share of 6.18% compared to the national financial market so they still have the potential to experience growth. Furthermore, sample used 14 Islamic commercial banks registered with the OJK during 2014-2019. The research method used panel data regression analysis. The results showed that the performance of Islamic Commercial Bank’s has an effect on executive compensation. Islamic Commercial Bank Executives have an obligation to improve company performance (ROA) because it affects the compensation received by the executive.
Supracricoid laryngectomy for recurrent laryngeal cancer after chemoradiotherapy: a systematic review and meta-analysis
Authors: Leone C.A. , Capasso P. , Topazio D. , Russo G. 
Published: April 2021

La recidiva e la persistenza del cancro della laringe dopo radioterapia rappresentano eventi insidiosi, i cui tassi di incidenza variano dal 13% al 36%. Lintervento di laringectomia sopracricoidea (LSC), con cricoioidopessia (CIP) o cricoioidoepiglottopessia (CIEP), è in grado di garantire risultati oncologici e funzionali affidabili per i pazienti selezionati affetti da carcinoma glottico o sopraglottico, sia in caso di neoplasia primitiva che di recidiva. La presente metanalisi ha lo scopo di valutare i parametri oncologici e funzionali nei pazienti trattati con LSC per recidiva di carcinoma squamocellulare della laringe dopo fallimento di radioterapia. La ricerca è stata effettuata sui databases MEDLINE, PubMed ed EMBASE (da gennaio 1990 a dicembre 2015, solo in lingua inglese). Per la metanalisi è stato impiegato il metodo DerSimonian e Laird con effetto midex random; leterogeneicità è stata misurata mediante I. Sono stati inclusi nella ricerca 276 articoli, tra i quali ne sono stati selezionati 14 per la metanalisi, per un totale di 291 pazienti. Lanalisi statistica ha mostrato una sopravvivenza globale (OS) a 5 anni del 80,2% (IC 0,719-0,885; I= 62%; p = 0,003) e una sopravvivenza libera da malattia (DFS) a 5 anni del 89,5% (IC 0,838-0,952; I= 52%; p = 0,022). Le indicazioni chirurgiche per una LSC dopo fallimento di radioterapia non cambiano rispetto a quelle adottate per pazienti con tumore primitivo. Pertanto, è stato ipotizzato che lattenta valutazione dellestensione del tumore, in caso di recidiva, potrebbe essere responsabile dellalto tasso di OS e DFS a 5 anni. Per quanto riguarda i parametri di valutazione funzionale precoce postoperatoria, il tempo medio di decannulazione è stato di 35,6 giorni (IC 24,3-46,9; I= 95%; p < 0,001), mentre il tempo medio di rimozione del sondino naso-gastrico (SNG) o della gastrostrostomia percutanea endoscopica (PEG) è stato di 28,3 giorni (IC 22,7-33,8; I= 86%; p <= 0.001). Questi dati sono in accordo con gli Autori che preferiscono la rimozione precoce del sondino nasogastrico. In tal modo si può riprendere lalimentazione orale quando è ancora presente il tubo endotracheale a protezione delle vie aree e permettere laspirazione degli eventuali residui alimentari.
Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
Authors: Canzi P. , Cacciola S. , Capaccio P. , Pagella F. , Occhini A. , Pignataro L. , Benazzo M. 
Published: April 2021

La tossicità delle ghiandole salivari rappresenta un noto effetto indesiderato dello iodio radioattivo (I) utilizzato per il trattamento di neoplasie tiroidee, con una prevalenza che varia dal 2% al 67% della popolazione esposta. Recentemente, la scialoendoscopia è stata introdotta come un interessante strumento diagnostico e terapeutico per la gestione dei pazienti affetti da scialoadenite radioiodio-indotta non responsiva ai trattamenti medici standard. Lobiettivo della presente revisione è stato valutare linfluenza di questa procedura sulla storia clinica di pazienti affetti da scialoadenite conseguente a trattamento con radioiodio. Complessivamente, la revisione ha incluso 8 studi, 122 pazienti e 264 scialoendoscopie. Le stenosi duttali ed i tappi mucosi hanno rappresentato l85.7% dei reperti endoscopici, sostenendo il ruolo dellostruzione duttale nella fisiopatologia della scialoadenite da radioiodio. Circa l89.3% dei pazienti riportarono una risoluzione parziale o completa degli episodi di scialoadenite ricorrente, senza complicanze post-operatorie maggiori. Un solo caso è stato sottoposto a parotidectomia per fallimento del trattamento scialoendoscopico e persistenza dei sintomi. Tuttavia, i risultati della letteratura riguardarono principalmente valutazioni soggettive e solamente in due esperienze cliniche furono prese in considerazione misure oggettive con risultati discordanti. La xerostomia fu analizzata in pochi studi, con benefici differenti rispetto ai sintomi ostruttivi. La tempistica ideale per la videoendoscopia delle ghiandole salivari necessita di ulteriori analisi, al fine di definire la miglior gestione delle scialoadeniti ostruttive radioiodio-indotte.
Producing metabolic complexes of probiotic microorganisms with significant antimicrobial properties
Authors: Isaienko O. Yu. , Kotsar O. V. , Ryzhkova T. M. , Diukareva H. I. 
Published: April 2021

The aim of the work – to produce metabolic complexes with significant antibacterial properties using a new proprietary method and to substantiate the prospects of their use for designing of antimicrobial polyfunctional drugs.
Materials and methods. Metabolic complexes of Lactobacillus rhamnosus GG, Lactobacillus plantarum, Saccharomyces boulardii, Enterococcus faecium were obtained by culturing the producers in ultrasonic disintegrates of other probiotic microorganisms. Sensitivity of antibiotic-resistant strains of Escherichia coli PR and Staphylococcus haemolyticus PR was determined by qualitative method. The suspension of test-cultures (optical density of 1.0 units on the McFarland scale) after incubation with metabolites (2, 24 and 48 hours at 37 °C) was inoculated into Mueller–Hinton agar. The absence of growth was indicative of the metabolic complexes antibacterial activity against the microorganism.
Results. Cultivation of S. boulardii in the S. boulardii / L. rhamnosus / L. plantarum / E. faecium disintegrates, L. plantarum – in the L. rhamnosus / E. faecium disintegrates and L. rhamnosus – in the L. plantarum disintegrates was accompanied by an increase in the biomass of isolated microorganisms (P ≤ 0.03) and production of metabolites. Along with a similar increase in S. boulardii cells in the S. boulardii / L. rhamnosus / L. plantarum / E. faecium disintegrates, the metabolic products of lactobacterial and enterococcal disintegrates exhibited more active inhibitory effects against E. coli PR and S. haemolyticus PR. The increased antibacterial activity indicates the advantage of the new method. Another improvement is the extended spectrum of metabolic complexes owing to producer cultivation in the other probiotic disintegrates to obtain original biologically active substances with high antibacterial properties against pathogens. Among the strength of the method is that all the stages are unified into a single process avoiding multiphase procedure for the separate preparation of one probiotic microorganism disintegrate and the metabolic products of another.
Conclusions. Disintegrates as a nutrient medium can be used not only for their own producers, but also for other strains/species and various probiotic microorganisms (fungi and bacteria). The increase in antibacterial activity of metabolic complexes has been found using the new method of production. The prospects of antimicrobial polyfunctional drugs designing on this basis have been proved.
ParaX
Authors: Yin Lujia , Zhang Yiming , Zhang Zhaoning , Peng Yuxing , Zhao Peng 
Published: April 2021

Despite the fact that GPUs and accelerators are more efficient in deep learning (DL), commercial clouds like Facebook and Amazon now heavily use CPUs in DL computation because there are large numbers of CPUs which would otherwise sit idle during off-peak periods. Following the trend, CPU vendors have not only released high-performance many-core CPUs but also developed efficient math kernel libraries. However, current DL platforms cannot scale well to a large number of CPU cores, making many-core CPUs inefficient in DL computation. We analyze the memory access patterns of various layers and identify the root cause of the low scalability, i.e., the per-layer barriers that are implicitly imposed by current platforms which assign one single instance (i.e., one batch of input data) to a CPU. The barriers cause severe memory bandwidth contention and CPU starvation in the access-intensive layers (like activation and BN).
This paper presents a novel approach called ParaX, which boosts the performance of DL on many-core CPUs by effectively alleviating bandwidth contention and CPU starvation. Our key idea is to assign one instance to each CPU core instead of to the entire CPU, so as to remove the per-layer barriers on the executions of the many cores. ParaX designs an ultralight scheduling policy which sufficiently overlaps the access-intensive layers with the compute-intensive ones to avoid contention, and proposes a NUMA-aware gradient server mechanism for training which leverages shared memory to substantially reduce the overhead of per-iteration parameter synchronization. We have implemented ParaX on MXNet. Extensive evaluation on a two-NUMA Intel 8280 CPU shows that ParaX significantly improves the training/inference throughput for all tested models (for image recognition and natural language processing) by 1.73X ~ 2.93X.
Charting the design space of query execution using VOILA
Authors: Gubner Tim , Boncz Peter 
Published: April 2021

Database architecture, while having been studied for four decades now, has delivered only a few designs with well-understood properties. These few are followed by most actual systems. Acquiring more knowledge about the design space is a very time-consuming processes that requires
manually
crafting prototypes with a low chance of generating material insight.

We propose a framework that aims to accelerate this exploration process significantly. Our framework enables synthesizing many different engines from a description in a carefully designed domain-specific language (VOILA). We explain basic concepts and formally define the semantics of VOILA. We demonstrate VOILA's flexibility by presenting translation back-ends that allow the synthesis of state-of-the-art paradigms (data-centric compilation, vectorized execution, AVX-512), mutations and mixes thereof.
We show-case VOILA's flexibility by exploring the query engine design space in an automated fashion. We generated thousands of query engines and report our findings. Queries generated by VOILA achieve similar performance as state-of-the-art hand-optimized implementations and are up to 35.5X faster than well-known systems.
On the set of positive solutions for resonant Robin (p,q)-equations
Authors: Papageorgiou Nikolaos S. , Zhang Youpei 
Published: April 2021

AbstractWe consider a nonlinear Robin problem driven by the (p,q)-Laplacian and a parametric reaction exhibiting the competition of a concave term and of a resonant perturbation. We prove a bifurcation-type theorem describing the changes in the set of positive solutions as the parameterλmoves on ℝ̊+= (0, +∞). Also, we determine the continuity properties of the solution multifunction.
CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior
Authors: Fujima Shuhei , Yamaga Ryosuke , Minami Haruka , Mizuno Shota , Shinoda Yo , Sadakata Tetsushi , Abe Manabu , Sakimura Kenji , Sano Yoshitake , Furuichi Teiichi 
Published: April 2021

Ca2+-dependent activator protein for secretion 2 (CAPS2) regulates dense-core vesicle (DCV) exocytosis to facilitate peptidergic and catecholaminergic transmitter release. CAPS2 deficiency in mice has mild neuronal effects but markedly impairs social behavior. Rarede novo Caps2alterations also occur in autism spectrum disorder, although whether CAPS2-mediated release influences social behavior remains unclear. Here, we demonstrate that CAPS2 is associated with DCV exocytosis-mediated release of the social interaction modulatory peptide oxytocin (OXT). CAPS2 is expressed in hypothalamic OXT neurons and localizes to OXT nerve projection and OXT release sites, such as the pituitary.Caps2KO mice exhibited reduced plasma albeit increased hypothalamic and pituitary OXT levels, indicating insufficient release. OXT neuron-specificCaps2conditional KO supported CAPS2 function in pituitary OXT release, also affording impaired social interaction and recognition behavior that could be ameliorated by exogenous OXT administered intranasally. Thus, CAPS2 appears critical for OXT release, thereby being associated with social behavior.SIGNIFICANCE STATEMENTThe role of the neuropeptide oxytocin in enhancing social interaction and social bonding behavior has attracted considerable public and neuroscientific attention. A central issue in oxytocin biology concerns how oxytocin release is regulated. Our study provides an important insight into the understanding of oxytocin-dependent social behavior from the perspective of the CAPS2-regulated release mechanism.
An undiagnosed TSH-secreting pituitary macroadenoma found during pregnancy
Authors: Ng Chi-Hong , Chow Wing-Sun , Lam Karen Siu-Ling , Lee Chi-Ho 
Published: April 2021

Summary
Thyroid stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is an uncommon cause of thyrotoxicosis, and is even rarer when found during pregnancy. Our patient presented with thyrotoxicosis accompanied by an inappropriately normal TSH level at 10 weeks of gestation during work-up of surgical termination of pregnancy (STOP). Subsequent investigations performed after STOP confirmed the presence of a TSH-secreting pituitary macroadenoma. She was initially treated with anti-thyroid drugs for biochemical control, followed by trans-sphenoidal surgery after STOP had been performed. Her thyroid function completely normalized after the trans-sphenoidal surgery. Our case illustrated the importance of recognizing the syndrome of inappropriate TSH secretion and highlighted several pregnancy-related aspects in the diagnosis and management of TSHoma during pregnancy.

Learning points:

This case report illustrates the need to raise awareness in recognizing the syndrome of inappropriate TSH secretion.

Illustrate the different hormone tests available for reaching the diagnosis of TSH-secreting pituitary adenoma.

Highlight the physiological changes in the thyroid status during pregnancy and the importance of using trimester-specific reference ranges for assessment of thyroid function during pregnancy.

Describe the challenges in the management of TSH-secreting pituitary adenoma during pregnancy.
MORPHOLOGICAL AND GENETIC DIVERSITY ANALYSIS IN CALENDULA (CALENDULA OFFICINALIS L.) INFLUENCED BY MUTAGENIC EFFECT OF COLCHICINE
Authors: Yassein Ahmed , Hassan Abdallah , Abdel-Alah Ebtsam , Salim Shokri 
Published: April 2021

Calendula officinalis L. (pot marigold) is one of the main aromatic and medicinal plants with many uses in food and medicines. This study was carried out to demonstrate the efficiency of six colchicine concentrations (0.025, 0.05, 0.1, 0.2, 0.4 and 0.8 per cent, w/v) for Calendula improvement and induction of genetic variation. Colchicine treatments had a positive effect on the number of branches/plant, number of inflorescences, fresh and dry weight of inflorescences, inflorescence diameter, total soluble carbohydrates and β-carotene except for plant height, while seed germination and plant height were reduced. Estimation of heritability, genetic advance, genetic variability and selection of superior genotypes will be an important object in crop breeding and genetic improvement programs, and selection of genotypes with higher desirable characters. Heritability was high and ranged from 48.64 to 90.81, respectively (inflorescence diameter and plant height, respectively). Molecular markers based on a RAPD-PCR study elucidate the classification of induced Calendula mutants into two clusters. The coefficient of genetic diversity was estimated at 30%. A combination of morphological and physiological responses with molecular data contained in the various colchicine treatments illustrated the utility of RAPD-PCR as a method for identifying useful mutants and could be used to detect the colchicine effect significantly. Findings recommend the 0.05 per cent colchicine for efficient breeding calendula mutation and genetic improvement.
Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act
Authors: Abdel-Rahman Susan M. , Paul Ian M. , Hornik Chi , Sullivan Janice E. , Wade Kelly , Delmore Paula , Sharma Gaurav , Benjamin Daniel K. , Zimmerman Kanecia O. 
Published: April 2021

BACKGROUND AND OBJECTIVES:
The Best Pharmaceuticals for Children Act (BPCA) incentivizes the study of on-patent medicines in children and mandates that the National Institutes of Health sponsor research on off-patent drugs important to pediatric therapeutics. Failing to enroll cohorts that reflect the pediatric population at large restricts the generalizability of such studies. In this investigation, we evaluate racial and ethnic minority representation among participants enrolled in BPCA-sponsored studies.

METHODS:
Data were obtained for all participants enrolled in 33 federally funded studies of drugs and devices conducted from 2008 through June 2020. Observed racial and ethnic distributions were compared with expected distributions by sampling Census data at the same geographic frequency as in the studies. Racial and ethnic enrollment was examined by demography, geography, study type, study burden, and expected bias. Standard descriptive statistics, χ2, generalized linear models, and linear regression were applied.

RESULTS:
A total of 10 918 participants (51% male, 6.6 ± 8.2 years) were enrolled across 46 US states and 4 countries. Studies ranged from treatment outcome reviews to randomized, placebo-controlled trials. Minority enrollment was comparable to, or higher than, expected (+0.1% to +2.6%) for all groups except Asian Americans (−3.7%, P &lt; .001). American Indian and Alaskan Native and multiracial enrollment significantly increased over the evaluation period (P &lt; .01). There were no significant differences in racial distribution as a function of age or sex, although differences were observed on the basis of geography, study type, and study burden.

CONCLUSIONS AND RELEVANCE:
This study revealed no evidence of racial and ethnic bias in enrollment for pediatric studies conducted with funding from BPCA, fulfilling the legislation’s expectation to ensure adequate representation of all children.
Digital Transformation In Indian Insurance Industry
Authors: Et. al. Ramesh Kumar Satuluri, 
Published: April 2021

This paper titled “Digital Transformation in Indian Insurance Industry” is an attempt to give deep insights to all the readers on digital transformation in insurance space. Technological innovations are extensive and all encompassing. Disruptions are not industry specific and insurance industry is no exception to this. Recently regulator published a draft regulation on sandbox concept, which permits carriers to innovate their offering to end user. This is led by fintech and insure tech companies and carriers have structured digital boards to take this revolution forward.Major findings of this paper are usage of block chain technology and data security in insurance industry. With companies constituting digital boards, pandemic has only acted like a tailwind for the digital push wherein entire sales process is migrated to digital way of selling. This move has a multiplier effect on customer reach, cost efficiency and service precision. Customers who are keen to have the best in terms of technological innovation will be delighted with the advancement in digital transformation.Also with big data and analytics, we are coming back to risk based pricing, which is proportionate to the risk borne by the customer. This is still evolving in life insurance as the deployment of wearables is at a nascent stage.Newer technologies like AI and machine learning are facilitating companies register higher growth both on cross and upsell opportunities. This will indisputably have an immense and long term positive impact on the bottom line of most insurance companies thus enhancing profitability.Researcher concludes that digital innovation will surely have a great and positive impact on profitability of insurance companies.
Extracurricular Activities Are A Key Element In The Organization Of The Educational Process
Authors: Et. al. G. Narkabilova, 
Published: April 2021

The article describes the factors, conditions, the principle of communicative activity (as a component of the principle of activity), signs, opportunities in creating conditions for the development of many areas of the student's personality, goals, objectives, content and forms of extracurricular activities. A systemically organized extracurricular lesson includes methods of teaching, upbringing and development that stimulate students to master knowledge and skills on their own, and also disposes to more informal interaction with teachers, which leads to the disappearance of the framework of the formal relationship and the disclosure of the internal potential of students.
Factor Structure Analysis for Pedestrian Level of Service Assessment using Structural Equation Modelling
Authors: Et. al. Jivesh Ujjwal, 
Published: April 2021

Pedestrian facilities are aimed at providing proper walking infrastructure and environment to promote walking in cities and needs to serve the desired requirements of users. It is important to assess the level of service (LOS) provided by such facilities. Various guidelines are available for assessing LOS of sidewalks, midblock crossings and pedestrians walking along the carriageway. However, the guidelines and factors considered for assessment are diverse and no single guideline is available that comprehensively takes into account all variables relevant for both sidewalks and crossings and for mixed land use settings.
This work thus attempts to identify factors and their underlying variables and also the relative importance of the factors in determining LOS of pedestrian facilities in mixed land use areas. For this purpose, the study systematically identifies a comprehensive list of 20 important variables associated with LOS assessment for pedestrian facilities from literature. A survey was conducted of a heterogeneous group of 720 pedestrians from Patna, India to find importance perceptions of all the above identified variables. The important factors and their significant underlying variables were then identified using Exploratory Factor Analysis and the factor structure was confirmed using Structural Equation Model using survey data. Five factors namely Infrastructure, Crossing issues, Security, Sidewalk encroachments and Safety were identified with 13 significant underlying variables. It was observed that the crossing facility conditions predominantly influence the perception of LOS of pedestrian facilities. The findings of the study can be used by urban planners in focusing their improvement efforts for pedestrian facilities.