bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
Authors: Das Yudhajit , Wang Xinlong , Kota Srinivas , Zhang Rong , Liu Hanli , Chalak Lina F. 
Published: May 2021

AbstractThere is a critical need for development of real time physiological biomarkers for birth asphyxia that constitutes a major global public health burden. Our recent study (Scientific Reports, V10:9183, 2020) established a novel non-invasive neurovascular coupling (NVC) assessment in newborns using dynamic wavelet transform coherence (WTC) analysis irrespective of different aEEG algorithms. As an extended study, the current paper examines whether the variability in processed EEG and amplitude-EEG (aEEG) outputs would impact the determination of NVC in newborns with encephalopathy. Concurrent processed EEG tracings and regional near infrared spectroscopy (NIRS)-based cerebral tissue oxygen saturation (SctO2) readings during a period of twenty hours in their first day of life were selected and processed in this study. After bandpass-filtered in 2–15 Hz, rectified, and down-sampled at 0.21 Hz, the processed EEG tracings along with NIRS-SctO2 (0.21 Hz) were used to perform WTC analysis, followed by comparison of WTC-metrics between SctO2-processed EEG coherence and SctO2-aEEG coherence using Bland–Altman statistics. Our results demonstrated high and significant correlation (R2 = 0.96, p < 0.001) between NVC assessments by SctO2-processed EEG and SctO2-aEEG coherence, confirming that band-passed, rectified, and down-sampled processed EEG, or aEEG, can be paired with NIRS-SctO2 to assess NVC in newborns with encephalopathy. Findings indicate the feasibility of a simpler approach to NVC in neonates by using directly processed EEG, instead of aEEG.
Discovery of a new mammal species (Soricidae: Eulipotyphla) from Narcondam volcanic island, India
Authors: Kamalakannan Manokaran , Sivaperuman Chandrakasan , Kundu Shantanu , Gokulakrishnan Govindarasu , Venkatraman Chinnadurai , Chandra Kailash 
Published: May 2021

AbstractWe discovered a newCrociduraspecies of shrew (Soricidae: Eulipotyphla) from Narcondam Island, India by using both morphological and molecular approaches. The new species,Crocidura narcondamicasp. nov. is of medium size (head and body lengths) and has a distinct external morphology (darker grey dense fur with a thick, darker tail) and craniodental characters (braincase is rounded and elevated with weak lambdoidal ridges) in comparison to other close congeners. This is the first discovery of a shrew from this volcanic island and increases the total number ofCrocidura species catalogued in the Indian checklist of mammals to 12. The newly discovered species shows substantial genetic distances (12.02% to 16.61%) to otherCrocidura species known from the Indian mainland, the Andaman and Nicobar Archipelago, Myanmar, and from Sumatra. Both Maximum-Likelihood and Bayesian phylogenetic inferences, based on mitochondrial (cytochrome b) gene sequences showed distinct clustering of all included soricid species and exhibit congruence with the previous evolutionary hypothesis on this mammalian group. The present phylogenetic analyses also furnished the evolutionary placement of the newly discovered species within the genusCrocidura.
Inhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo
Authors: Song Eun-Jung , Españo Erica , Shim Sang-Mu , Nam Jeong-Hyun , Kim Jiyeon , Lee Kiho , Park Song-Kyu , Lee Chong-Kil , Kim Jeong-Ki 
Published: May 2021

AbstractInfluenza viruses cause significant morbidity and mortality worldwide. Long-term or frequent use of approved anti-influenza agents has resulted in drug-resistant strains, thereby necessitating the discovery of new drugs. In this study, we found aprotinin, a serine protease inhibitor, as an anti-influenza candidate through screening of compound libraries. Aprotinin has been previously reported to show inhibitory effects on a few influenza A virus (IAV) subtypes (e.g., seasonal H1N1 and H3N2). However, because there were no reports of its inhibitory effects on the other types of influenza viruses, we investigated the inhibitory effects of aprotinin in vitro on a wide range of influenza viruses, including avian and oseltamivir-resistant influenza virus strains. Our cell-based assay showed that aprotinin had inhibitory effects on seasonal human IAVs (H1N1 and H3N2 subtypes), avian IAVs (H5N2, H6N5, and H9N2 subtypes), an oseltamivir-resistant IAV, and a currently circulating influenza B virus. We have also confirmed its activity in mice infected with a lethal dose of influenza virus, showing a significant increase in survival rate. Our findings suggest that aprotinin has the capacity to inhibit a wide range of influenza virus subtypes and should be considered for development as a therapeutic agent against influenza.
Epilepsy lifetime prevalence in Iran: a large population- based national survey
Authors: Pakdaman Hossein , Harandi Ali Amini , Gharagozli Koroush , Alaeddini Farshid , Esfandani Akram , Mirbehbahani Seyed Hamidreza , Doroudi Taher , Kolivand Pirhossein , Bahrami Parviz , Kazemi Hadi 
Published: May 2021

AbstractEpilepsy has garnered increased public health focus because patients who suffer from epilepsy experience pronounced and persistent health and socioeconomic disparities despite treatment and care advances. The epidemiology of epilepsy is diverse in different countries and regions. This nationwide population-based cross-sectional study was conducted to determine the life time prevalence and health related factors of epilepsy for the first time in Iran through a two-phase door-to-door survey method. In phase I, a screening for epilepsy was performed on 68,035 people. Then in phase II, after the neurological evaluation of participants and reviewing medical records, 1130 subjects with epilepsy was confirmed. The life time prevalence of epilepsy was achieved to be 16.6 per 1000 people (95% CI 15.4–17.8) with the average age onset 19.1 ± 21.1 (active prevalence 9.5 per 1000 people). Focal seizure (59.3%), generalized epilepsy (38%) and unknown types of epilepsy (2.7%) were detected among participants. The overall life time prevalence of febrile convulsion was 4.1 per 1000 people. The frequency of attacks per year and per month were 3.0 ± 1.6 and 0.5 ± 0.1, respectively. Age-specific life time prevalence was highest among the age group of 15–19 years old [32.7 per 1000 persons (95% CI 29.1–36.8)] and it was higher in male (53.8%) than female (46.2%) participants. Our results showed that the life time prevalence of epilepsy in Iran is higher than worldwide average.
An area‐efficient memory‐based multiplier powering eight parallel multiplications for convolutional neural network processors
Authors: Choi Seongrim , Cho Suhwan , Nam Byeong‐Gyu 
Published: May 2021

AbstractConvolutional neural network (CNN) is widely used for various deep learning applications because of its best‐in‐class classification performance. However, CNN needs several multiply‐accumulate (MAC) operations to realize human‐level cognition capabilities. In this regard, an area‐efficient multiplier is essential to integrate a large number of MAC units in a CNN processor. In this letter, we present an area‐efficient memory‐based multiplier targeting CNN processing. The proposed architecture adopts a 32‐port memory shared across eight multiplications. Simulation results show that area is reduced by 18.4% compared with the state‐of‐the‐art memory‐based multiplier.
A Quasi open‐loop robust three‐phase grid‐synchronization technique for non‐ideal grid
Authors: Ahmed Hafiz , Biricik Samet , Benbouzid Mohamed 
Published: May 2021

AbstractDevelopment of advanced grid‐synchronization technique for unbalanced and distorted grid is considered in this paper. In this context, self‐tuning filter (STF) is considered to extract the fundamental component from the measured unbalanced and distorted voltages. Standard STF considers balanced grid voltages which is not always possible to ensure in the actual power grid. To mitigate this issue, an extended STF is proposed by analyzing the standard STF in the state‐space framework. To make the proposed ESTF grid‐following, a robust open‐loop frequency estimator is also applied. The closed‐loop system enjoys excellent filtering benefit from the extended STF side while taking advantage of the fast convergence speed property of the open‐loop frequency estimation technique. Numerical simulation and experimental results with double second‐order generalized integrator phase‐locked loop are provided to validate the theoretical developments.
Image encryption algorithm for crowd data based on a new hyperchaotic system and Bernstein polynomial
Authors: Jiang Donghua , Liu Lidong , Wang Xingyuan , Rong Xianwei 
Published: May 2021

AbstractA new two‐dimensional chaotic system in the form of a cascade structure is designed, which is derived from the Chebyshev system and the infinite collapse system. Performance analysis including trajectory, Lyapunov exponent and approximate entropy indicate that it has a larger chaotic range, better ergodicity and more complex chaotic behaviour than those of advanced two‐dimensional chaotic system recently proposed. Moreover, to protect the security of the crowd image data, the newly designed two‐dimensional chaotic system is utilized to propose a visually meaningful image cryptosystem combined with singular value decomposition and Bernstein polynomial. First, the plain image is compressed by singular value decomposition, and then encrypted to the noise‐like cipher image by scrambling and diffusion algorithm. Later, the steganographic image is obtained by randomly embedding the cipher image into a carrier image in spatial domain through the Bernstein polynomial‐based embedding method, thereby realizing the double security of image information and image appearance. Besides, the visual quality of the steganographic image can be improved by the adjustment factor according to different carrier images during the embedding process. Ultimately, security analyses indicate that it has higher encryption efficiency (2 Mbps) and the visual quality of steganography image can reach 39 dB.
Epidemiology and Injury Pattern of E-Scooter Injuries – Initial Results
Authors: Heuer Sarah , Landschoof Sönke , Kornherr Patrick , Grospietsch Ben , Kühne Christian A. 
Published: May 2021

Abstract
Aim Since the introduction of shared electric scooters in Germany in June 2019, surgeons have been treating injuries caused by these devices.
Methods In our Institution, we implemented the first registry to examine the pattern of injuries and to gather epidemiological data on persons injured while riding electric scooters. We conducted a prospective analysis of all patients treated in our Emergency Department for an injury sustained while riding an electric scooter between June 2019 and June 2020. All patients were noted in a registry (E-SCORE = E-Scooter Register). The study was approved by the institutional ethics board. Outcomes were first time of use, injuries, imaging, alcohol and helmet use, age, length of hospital stay and surgical therapy.
Results 90 patients were identified. Mean age was 35.6 years (± 15.4); 65.5% were male. We diagnosed 32 fractures and 7 ligament injuries. Injuries to the head were found in 38 patients; 8 had relevant intracerebral or maxillofacial injuries. Alcohol use was noted in 18 (20%) patients, only 2 of whom wore a helmet (2.2%). 29 patients (32.2%) required surgical intervention.
Conclusion This study highlights the significant number of head injuries in patients riding electric scooters. Nevertheless, there are also a significant number of injuries to the bones and ligaments, which required surgical treatment. Hardly any of the patients was wearing a helmet and alcohol use was not unusual. In our opinion, scooter related injuries are leading to an growing number of vehicle related injuries and could probably benefit from some legal regulations, such as a blood alcohol limit and recommendation for helmet use. Implementation of a nationwide registry might be useful in evaluating injuries related to electric scooters.
Endoscopic Endonasal Transethmoidal-Transsphenoidal Approach to a Cavernous Sinus Chondrosarcoma
Authors: Agresta Gianluca , Campione Alberto , Pozzi Fabio , Veiceschi Pierlorenzo , Venturini Martina , Agosti Edoardo , Balbi Sergio , Battaglia Paolo , Locatelli Davide 
Published: May 2021

Abstract
Objective We illustrate a cavernous sinus chondrosarcoma treated with an endoscopic endonasal transethmoidal-transsphenoidal approach.
Design Case report of a 15-year-old girl with diplopia and esotropia due to complete abducens palsy. Preoperative images showed a right cavernous sinus lesion with multiple enhanced septa and intralesional calcified spots (Fig. 1). Considering tumor location and the lateral dislocation of the carotid artery, an endoscopic endonasal approach was performed to relieve symptoms and to optimize the target geometry for adjuvant conformal radiotherapy.
Setting The study was conducted at University of Insubria, Department of Neurosurgery, Varese, Italy.
Participants Skull base team was participated in the study.
Main Outcome Measures A transethmoidal-transsphenoidal approach was performed by using a four-hand technique. We used a route lateral to medial turbinate to access ethmoid and the sphenoid sinus. During the sphenoid phase, we exposed the medial wall of the cavernous sinus (Fig. 2) and the lesion was then removed using curette. Skull base reconstruction was performed with fibrin glue and nasoseptal flap.
Results No complications occurred after surgery, and the patient experienced a complete recovery of symptoms. A postoperative magnetic resonance imaging showed a small residual tumor inside the cavernous sinus (Fig. 1). After percutaneous proton-bean therapy, patient experienced only temporary low-grade toxicity with local control within 2 years after treatment completion.
Conclusion Endoscopic endonasal extended approach is a safe and well-tolerated procedure that is indicated in selected cases (intracavernous tumors, soft tumors not infiltrating the vessels and/or the nerves). A tailored approach according to tumor extension is crucial for the best access to the compartments involved.The link to the video can be found at: https://youtu.be/TsqXjqpuOws.
Endoscopic Transnasal Resection of Trigeminal Schwannoma
Authors: Kiyofuji Satoshi , Shin Masahiro , Kondo Kenji , Kin Taichi , Uchida Tatsuya , Saito Nobuhito 
Published: May 2021

AbstractTrigeminal schwannoma is a rare skull base tumor that can be managed in a variety of treatments including image observation, surgery, stereotactic radiosurgery, such as gamma knife radiosurgery (GKS), and combination of these. Endoscopic transnasal resection is very effective when the tumor is not invading far laterally, or the risk of cerebrospinal fluid (CSF) leak is estimated to be low. A 74-year-old man with a history of prostate cancer and diabetes presented with left oculomotor nerve palsy over a month. Magnetic resonance images (MRI) demonstrated a 25-mm mass in the left cavernous sinus protruding to the left orbit via the superior orbital fissure (Fig. 1). The patient underwent endoscopic transnasal surgery to decompress the mass. The surgery was uneventful, and postoperative MRI demonstrated satisfactory subtotal resection of the mass (Fig. 2). The final pathology returned as schwannoma. At 1-year follow-up, the tumor slowly enlarged, and the patient underwent GKS with a marginal dose of 14 Gy. At the last follow-up, 4 months after GKS, the tumor was stable. Unfortunately the patient deceased from the known prostate cancer. Endoscopic transnasal surgery was especially useful in this case, considering the preoperative known cancer state that management of this benign tumor did not ruin the quality of life of this patient while minimizing hospitalization, as achieving satisfactory tumor control with aid from postoperative GKS, minimizing complications.The link to the video can be found at: https://youtu.be/Q0Ugc2VFV4w.
Considering Criteria for Active Phase Labor Management of Nulliparous Women: A Cost-Effectiveness Analysis
Authors: Schmidt Eleanor M. , Hersh Alyssa R. , Tuuli Methodius , Cahill Alison G. , Caughey Aaron B. 
Published: May 2021

Objective The aim of the study is to evaluate differences in maternal and neonatal outcomes based on updated criteria for defining active labor at 6 cm of cervical dilation and to determine if these recommendations are cost-effective.
Study Design A decision-analytic model was built using TreeAge Pro 2020 software. We included maternal outcomes of mode of delivery, endometritis, postpartum hemorrhage requiring transfusion, and death. Neonatal outcomes included rates of shoulder dystocia and permanent brachial plexus injury. Costs and quality-adjusted life years (QALYs) were included from the maternal and infant perspectives. We used a willingness-to-pay threshold of $100,000 per QALY and all model inputs were subjected to sensitivity analysis.
Results In a theoretical cohort of 1.4 million women, a threshold of 6 cm to define active labor resulted in 373,668 fewer cesarean deliveries, 33,181 fewer cases of endometritis, 143 fewer postpartum hemorrhages requiring transfusions, and seven fewer maternal deaths when compared with a threshold of 4 cm. However, there were higher rates of adverse neonatal outcomes, including 484 more cases of shoulder dystocia and 17 more instances of permanent brachial plexus injury. Using 6 cm as the threshold resulted in lower costs and greater effectiveness, making it a dominant strategy. Multivariate sensitivity analysis demonstrated the model was robust over a wide range of assumptions.
Conclusion In this model, considering 6 cm of cervical dilation as the threshold for the active phase of labor compared with 4 cm was a cost-effective strategy to prevent primary cesarean deliveries, lower costs, and improve maternal outcomes, despite associated increased adverse neonatal outcomes.
Key Pointsg
Perioperative Opioid Use in Anterior Cruciate Ligament Reconstruction Patients
Authors: Aneizi Ali , Friedmann Elizabeth , Henry Leah E. , Perraut Gregory , Sajak Patrick M. J. , Ventimiglia Dominic J. , Burt Cameran I. , Zhang Tina , Packer Jonathan D. , Henn III R. F. 
Published: May 2021

AbstractAnterior cruciate ligament reconstruction (ACLR) is one of the most commonly performed outpatient orthopaedic procedures, yet there is little data about perioperative opioid prescribing practices. The purposes of this study were to quantify the perioperative opioid prescriptions filled by patients who underwent ACLR and to identify factors associated with greater postoperative opioid use. Patients who underwent ACLR at a single institution between June 2015 and May 2017 were studied using a regional prescription monitoring database to identify all preoperative and postoperative outpatient opioid prescriptions up to 2 years postoperatively. The number of morphine milligram equivalents of each opioid was calculated to determine total morphine milligram equivalents (TMEs) filled preoperatively, at discharge, and refilled postoperatively. Patients who refilled an opioid prescription postoperatively were compared with those who did not. Ninety-nine of 269 (36.8%) total patients refilled an opioid prescription postoperatively. Thirty-three patients (12.3%) required a refill after 2 weeks postoperatively, and no patients refilled after 21 months postoperatively. Fifty-seven patients (21%) received an opioid prescription in the 2 years following surgery that was unrelated to their ACL reconstruction. Increased age, higher body mass index (BMI), government insurance, current or prior tobacco use history, preoperative opioid use, and greater number of medical comorbidities were significantly associated with refilling a prescription opioid. Higher BMI and government insurance were independent predictors of refilling. Higher preoperative TMEs and surgeon were independent predictor of greater refill TMEs. In the opioid-naïve subgroup of 177 patients, only higher BMI was a predictor of refilling, and only greater comorbidities was a predictor of greater refill TMEs. The results demonstrate that preoperative opioid use was associated with postoperative opioid refills and higher refill TMEs in a dose-dependent fashion. A higher percentage of patients received an opioid prescription for reasons unrelated to the ACL reconstruction than refilled a prescription after the first 2 weeks postoperatively.
Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction Results in Superior Rotational Stability Compared with Isolated Anterior Cruciate Ligament Reconstruction in High Grade Pivoting Sport Patients: A Prospective Randomized Clinical Trial
Authors: Mogoş Ştefan , D'Ambrosi Riccardo , Antonescu Dinu , Stoica Ioan-Cristian 
Published: May 2021

AbstractThe purpose of the current randomized clinical trial (RCT) was to evaluate the clinical outcomes of combined anterior cruciate ligament (ACL) and anterolateral ligament (ALL) reconstruction and to compare them with those of isolated ACL reconstruction. The hypothesis was that combined ACL and ALL reconstruction will result in superior clinical outcomes in terms of the rotational stability of the knee. This prospective RCT included 57 patients (44 men and 13 women, mean age = 31 ± 7.1 years) who underwent ACL reconstruction either isolated (Group I: 25 patients) or combined with ALL reconstruction (Group II: 32 patients). The evaluation of the patients was done preoperatively and postoperatively at 6 weeks, 12 weeks, 6 months, and 12 months including a clinical examination (Lachman's test, Pivot shift's test, and Rolimeter differential anterior laxity), an objective clinical scores (objective: the International Knee Documentation Committee [IKDC] score) and a subjective clinical scores (subjective: IKDC's score, Lysholm's score, and Tegner's activity score). Postoperative complications of all the patients were recorded. There was a significant difference between the study groups at all follow-up intervals when evaluating the postoperative pivot shift test (p < 0.05) with a superior rotational stability in the group of combined ACL and ALL reconstruction. At the final follow-up evaluation, 36% of the patients from Group I and 6.2% in Group II had a grade I positive pivot shift test (p < 0.05). There was a statistically significant difference between the two groups regarding the number of patients with a grade A IKDC objective score (p < 0.05) at the 6- and 12-month follow-up intervals (p = 0.007). There was a significant difference concerning the IKDC subjective score between the two study groups in favor of the combined ACL and ALL reconstruction group at 12 months postoperatively (p = 0.048). Combined ACL and ALL reconstruction technique was demonstrated to be effective in obtaining a superior control of the rotational knee instability and to improve the clinical objective and subjective outcomes when compared with isolated ACL reconstruction in sports patients with high-grade pivoting shifts.