bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of accommodation function in contemporary schoolchildren with progressive myopia
Authors: Mahdi Abida 
Published: November 2021

The purpose of this study is to study the state of accommodative function in contemporary schoolchildren using the method of computer accommodation.
We studied 50 children (10-16 years old): 40 with different degrees of myopia and 10 children (control group) with emmetropia. The accommodation was studied with the computer accomodate Righton Speedy-K ver. MF-1. Defined power of accommodative response to accommodative stimulus imposed by calculating a ratio the coefficient of accommodative response (CAR) and the nature of the contraction of the fibers of the ciliary muscle by determining microfluctuations coefficient (CMF).
It was found that in groups of patients with emmetropia and weak myopia, the coefficient of accommodation response and the microfluctuation coefficient exceed the average normal values. Especially pronounced changes in the group of children with mild myopia. In groups of children with moderate and high myopia, the CAR is significantly lower than in mild myopia and emmetropia, while the CMF also exceeds normal values.
Empirical Correlations of Spectral Input Energy with Peak Amplitude, Cumulative, and Duration Intensity Measures
Authors: Cheng Yin , Liu Tongtong , Wang Jianfeng , Ning Chao-Lie 
Published: November 2021

ABSTRACTIn earthquake engineering, it is acknowledged that a vector of intensity measures (IMs) can better predict seismic structural responses than a single measure. Hence, a vector of IMs is widely applied in a number of applications, such as probabilistic seismic hazard analysis, probabilistic seismic risk analysis, and ground-motion selections. Spectral input energy (EI) has been demonstrated as a promising IM in earthquake engineering, especially in the energy-based seismic design of structures. However, this important measure has not been included in the vector of IMs. Therefore, it is worthwhile to incorporate EI with other important IMs by examining correlations. This study analyzes the empirical correlations of spectral EI with peak amplitude-based IMs, cumulative-based IMs, and duration-related IMs. It is found that spectral absolute EI has strong correlations with peak ground velocity at all investigated periods. However, spectral EI is negatively correlated with duration-based IMs. To demonstrate the applicability of the examined correlations, a simple example is finally presented by employing EI for the ground-motion selections and seismic hazard assessment based on the generalized conditional intensity measure approach.
Caracterización y Hallazgos Patológicos Forenses en Adolescentes Suicidas: Pasto 2015-2019
Authors: Chávez Muriel Iván Alexander , Benavides Madroñero Carlos Geovanni 
Published: November 2021

Este artículo corto se refiere al suicidio, muerte que resulta de la acción intencional de un individuo de hacerse daño a sí mismo. En el caso de los homicidas adolescentes, se ha evidenciado por parte del Instituto Nacional de Medicina Legal y Ciencias Forenses que se trata de un problema de salud pública, y que aun siendo obvia la causa del fallecimiento, para el experto forense puede no ser tan indiscutible la correlación que se desprende de los mecanismos fisiopatológicos que devienen del suicidio, con los hallazgos de la autopsia, en cuanto a la alteración de las funciones corporales cuando se realiza su interpretación. En consecuencia, el propósito es determinar las características y hallazgos patológicos forenses en víctimas de suicidio de 12 a 17 años de edad que ingresaron a Medicina Legal, estudio de caso: municipio de Pasto en los años 2015-2019. Es un estudio de caso de tipo descriptivo de corte transversal que requiere del análisis documental de la información registrada en las carpetas de los suicidas. Preliminarmente, se infiere que la causa de muerte generadora de asfixia mecánica mediante el mecanismo de ahorcamiento junto con el envenenamiento son características de actos suicidas de los adolescentes de Pasto.
MÉRITO DE NIETO ARTETA EN LA HERMENÉUTICA IUSFILOSÓFICA
Authors: Cerra Jiménez Luis Eduardo 
Published: November 2021

Las reflexiones que seguidamente expondré sobre Luis Eduardo Nieto Arteta se circunscribirán al análisis de su aporte jusfilosófico en la obra “La Interpretación de las normas jurídicas.”
Empezaré ese análisis tratando de poner a Nieto en contexto con su tiempo. Para ello parto de un referente obligado, la fecha en que se estima fue publicada esa obra, esto es, en 1945.
Con este ensayo que pongo a consideración de ustedes, intento establecer, en primer lugar, en retrospectiva, qué temáticas de la Hermenéutica Iusfilosófica que hoy conocemos, y que por razón de su tiempo, Nieto Arteta no estaba obligado a conocer
Brain-derived neurotrophic factor (BDNF) dan proses penuaan: sebuah tinjauan
Authors: Mudjihartini Ninik 
Published: November 2021

Brain-derived neurotrophic factor (BDNF) merupakan faktor neurotrofin yang berpengaruh dalam mendukung pembentukan, perkembangan neuron, dan mempertahankan keberadaan neuron. BDNF dapat ditemukan dan aktif pada hipokampus, korteks, dan otak depan. Penuaan merupakan proses multifaktorial yang ditentukan oleh faktor genetik dan faktor epigenetik. Penurunan kadar BDNF menurunkan kemampuan belajar dan mengingat, terjadi pada orang lanjut usia atau yang mengalami penyakit neurodegeneratif. Penelitian membuktikan bahwa kadar BDNF yang tinggi mampu meningkatkan plastisitas neuron. BDNF memiliki reseptor TrkB dan p75 yang menentukan suatu neuron dapat bertahan hidup atau sebaliknya terjadi apoptosis. BDNF-TrkB mendukung pembentukan short term memory dan perkembangan neuron khususnya dendrit. BDNF-p57 mengaktifkan NFkB yang berperan dalam maturasi sistem saraf pusat. Peran BDNF sangat dipengaruhi oleh reseptornya. Nutrisi, metabolisme, perilaku, dan stres memengaruhi ekspresi BDNF. Faktor lingkungan yang meningkatkan kadar BDNF dapat menunda penuaan dan meningkatkan kemampuan kognitif.
Penile Size in Term Neonates in Addis Ababa, Ethiopia: A Cross Sectional Study
Authors: Meskele Kisu , Yesuf Aman , Fantahun Bereket , Meseret Fikir 
Published: November 2021

Abstract
Background: Proper genital examination including stretched penile size in neonates is important. Stretched penile size is different from one nation to another nation, it needs a standard for a particular population.Objectives: is to establish the standard penile size for term newborns in Ethiopia.Methods: Hospital based cross sectional study was conducted on 221 term neonates delivered from March 1, 2020 to July 30, 2020 in St. Paul’s Hospital Millennium Medical College (SPHMMC) Results: The minimum and maximum measured penile length was 2.5, and 5 cm respectively with mean (± SD) of 3.28 ± 0.42. There was a weak positive correlation between stretched penile length and head circumference and body length. Neonates born via instrumental delivery had larger penile length.Conclusion: Mean stretched penile length in our study was 3.28 ± 0.42 cm. Based on our findings, penile length at ±2SD were 2.43 cm and 4.12 cm respectively.
Effects of autolyzed yeast on performance, blood parameters, intestinal morphometry, immunohistochemistry and microbiological parameters of weaned piglets in a tropical humid climate
Authors: Nogueira B.D. , Watanabe P.H. , de Mendonça Ingrid Barbosa , Andrade TIAGO , Araújo Lina , Pascoal Leonardo , Almeida J.M.S. , Guerra Ricardo , Silva I.N.G. da , Nepomuceno Rafael , Freitas E.R. , Morais D.N. 
Published: November 2021

Abstract
This study aimed to evaluate the effects of dietary supplementation of autolyzed yeast (AY) from fermentation of sugarcane on performance, blood parameters, intestinal morphometry, immunohistochemistry and microbiological parameters of weaned piglets of different weight categories. A total of 480 piglets were distributed in a 3 x 2 factorial design study, with three inclusion levels of AY (0, 4 and 8 g/kg) and two weight categories (light and heavy, 5.71 ± 0.21 kg and 6.99 ± 0.25 kg, respectively), i.e., 6 treatments with 8 replicates pen each. There was no significant interaction between weight category and linear or quadratic effect of AY levels on performance, blood parameters, intestinal morphometry, immunohistochemistry and microbiological parameters (P > 0.05). The dietary supply of AY for nursery piglets linearly decreased the monocytes concentration of the piglets at 63 days of age (P < 0.05). AY levels linearly increased the villus height, mucosal thickness, absorptive area and number of mitotic cells of the duodenum, as well as the villus height:crypt depth ratio, mucosal thickness and number of mitotic cells of the jejunum (P < 0.05). Heavy piglets had higher ADFI in all evaluated periods, as well as higher values of villus height in the duodenum, and mucosal thickness in the duodenum and jejunum than light animals (P < 0.05). Dietary supplementation of autolyzed yeast positively influences health status, intestinal morphometry and immunohistochemistry of nursery piglets. Heavy weaned piglets have higher feed intake and greater intestinal morfometry than light animals.
Identification of TUBB4A as a Prognostic Biomarker of Melanoma by Transcriptomic Data and in vitro Experiments
Authors: Zhang Jiaqi , Li Zhe , Liu Hui , Wu Qi , Sun Zhiqiang , Cao Yan , Gao Wei , Luo Judong , Liu Xuejun 
Published: November 2021

Abstract
Background

Melanoma is one of the most malignant skin carcinomas with high metastatic potential. Increasing evidences have demonstrated that β-tubulin 4A (TUBB4A) play key role in development and progression of several types of human cancer. However, the potential function of TUBB4A in cutaneous melanoma remains to be determined.
Methods

We first performed differential expression analysis between skin melanoma tissues and normal tissues from GEO and TCGA datasets, and then ran survival analysis to identify prognostic-related key genes. We went further to conduct the verification of in vitro biochemical experiments to explore the functional roles of key gene TUBB4A. Two small molecule inhibitors of TUBB4A, Dihydroartemisinin (DHA) and Nocodazole, were used to examined the effect on apoptosis and cell cycle progression of melanoma cells.
Results

We found that TUBB4A is markedly correlated to the overall survival of cutaneous melanoma patients. The co-expressed genes with TUBB4A are enriched in the melanoma-related pathways and function. Then, the experimental results showed that knockdown of TUBB4A inhibit the proliferation and migration of A375 and B16-F10 melanoma cells. Moreover, two small molecular agents targeting TUBB4A, Dihydroartemisinin and Nonocodazole, dpromote the apoptosis of melanoma cells and made the tumor cells significantly blocked in G2/M stage.
Conclusion

We identified and validated in vitro that TUBB4A may be a prognostic biomarker and therapeutic target for melanoma.
The Trend in Cesarean Myomectomies and The Risk of Obstetrical Complications in Korea
Authors: Kim Min Jeong , Lee Kyungeun , Park Jae Young , Jo Ji Hye , Park In Yang 
Published: November 2021

Abstract
Background

To evaluate the pregnancy outcomes and the risk of adverse obstetrical outcomes from cesarean myomectomy (CM) compared to cesarean section (CS)-only and to investigate the trend of surgeons in choosing CM.
Methods

A retrospective cohort study was done of all patients who underwent CS that was complicated with leiomyoma at two university hospitals from January 2010 to May 2020. All patients were categorized into the CM group or the CS-only group. We analyzed the demographic factors, obstetric factors, surgical outcomes, and possible risk factors for adverse outcomes between the two groups.
Results

A total of 438 women in the CS-only group and 341 women in the CM group were included. Women who underwent CS-only had significantly more history of a previous myomectomy and multiple leiomyomas compared to women who underwent CM. The gestational days at delivery and the pregnancy complications were significantly higher in the CS group. The mean size of the leiomyomas was larger in the CM group than in the CS only group (5.8 ± 3.2 cm vs 5.2 ± 3.1 cm, P = 0.005). Operation time and history of previous CS and preterm labor were higher in the CM group. It seems that preterm labor and abnormal presentation were relatively higher in the CM group than in the CS group due to the presence of leiomyoma. There were no significant differences in the pre and postoperative hemoglobin levels. The size of the leiomyoma (odds ratio [OR] = 1.162; 95% confidence interval [CI]: 1.07 – 1.25; P < 0.001) and operation time > 60 minutes (OR = 2.461; 95% CI: 1.45 – 4.15) were significant independent predictors of adverse outcomes after CM.
Conclusions

Cesarean myomectomy is a reliable and safe approach to prevent the need for another operation for remnant leiomyoma. In this study, surgeons seemed to perform CM when uterine leiomyomas were large, the subserosal type, or few in number. Standardized treatment guidelines for myomectomy during cesarean section in pregnant women with uterine fibroids should be established.
Equity and Efficiency of Medical and Health Resource Allocation in Western China Based on Health Resources Agglomeration Degree and Malmquist Index
Authors: Qiu Ju , Yan Ruixia 
Published: November 2021

Abstract
Background: There is unequal distribution and low utilization efficiency of medical and health resources among regions in China for regional inequality social and economic development. The social and economic development in western China is relatively backward nationwide. The quantity and quality of medical and health resources have become a social problem in western China. This study aims to evaluate the equity and efficiency of health resource allocation in western China. Methods: The research data are extracted from China Statistical Yearbook ( 2009 – 2019 ). We choose the health resource agglomeration degree ( HRAD ) theory and Malmquist index to evaluate the equity and efficiency of health resource allocation in western China. The HRAD shows the impact of demographic and geographic factors on health resource aggregation. Results: From the latest data in 2019, the equity of medical and health resources allocation based on geographical area in Inner Mongolia, Tibet, Qinghai and Xinjiang is poor. The equity of medical and health resources allocation based on population allocation in Yunnan, Tibet, Gansu, Qinghai, Ningxia and Xinjiang is poor. From 2009 to 2019, the equity of health resource allocation in western China are poor nationwide. The total factor productivity of Tibet, Qinghai, Ningxia and Xinjiang was less than 1, which were 0.994, 0.984, 0.974 and 0.994, respectively. The allocation of medical and health resources in western China is unfair. Conclusion: The government should pay attention to the horizontal flow of medical and health resources when investing in medical and health resources. Population and geographical factors should be taken into account when allocating health resources. The total factor productivity in the western region is greatly affected by the technological progress rate. We should increase investment in medical and health technology, and effectively optimize the equity and efficiency of medical and health resource allocation.
Association Between Obstructive Sleep Apnea and Gastroesophageal Reflux Adjusted for Obesity in Patients With Sleep Disorders: a Case-control Study
Authors: Kawaguchi Shimpei , Takeuchi Toshihisa , Kojima Yuichi , Ota Kazuhiro , Ozaki Haruhiko , Iwatsubo Taro , Hakoda Akitoshi , Sugawara Noriaki , Nishida Shinya , Tanaka Hironori , Mori Yosuke , Nakajima Noriyuki , Tanimura Hirohisa , Higuchi Kazuhide 
Published: November 2021

Abstract
Background: The association between obstructive sleep apnea syndrome (OSAS) and gastroesophageal reflux disease has been reported in multiple studies and meta-analyses. Although obesity has been cited as a common risk factor for both conditions, in Far East Asia, sleep apnea is often attributed to craniofacial anatomy, and patients with obstructive sleep apnea are not necessarily obese. In the present study, we investigated whether there is an association between obstructive sleep apnea and gastroesophageal reflux after adjusting for obesity.Method: The subjects were 230 patients with sleep disorders who visited the Sleep Center at Osaka Kaisei Hospital between May 2016 and November 2017. All patients underwent esophagogastroduodenoscopy. They were diagnosed with sleep disorders by a respiratory specialist, and all patients with suspected OSAS underwent polysomnography/portable monitoring. BMI was measured from the height and weight of all patients, and they were categorized into three groups: non-obese OSAS, obese OSAS, and control (non-OSAS). The presence or absence of reflux esophagitis in each group was compared using the Los Angeles classification.Results: There were 138 patients in the obese OSAS group, 71 patients in the non-obese OSAS group, and 21 patients in the control group. There was a greater prevalence of reflux esophagitis both in the obese and non-obese OSAS groups compared with the control group (both p<0.05). Multivariate logistic regression analysis including other factors showed that alcohol consumption was the most significant factor in the non-obese OSAS group (p<0.05), but the severity of OSAS as measured by the Apnea-hypopnea Index was not a significant factor (p=0.64).Conclusions: In patients with sleep disorders, OSAS is associated with gastroesophageal reflux regardless of obesity. Alcohol consumption is also a major factor in non-obese patients with OSAS. Since alcohol consumption is associated with the risk of esophageal squamous cell carcinoma and gastroesophageal reflux is associated with the risk of esophageal adenocarcinoma, regular upper gastrointestinal endoscopy is thought to be necessary in patients at risk.
Tribology of The Sock-Skin Interface – The Influence of Different Fabric Parameters On Sock Friction
Authors: DeBois Ian , Agarwal Esha , Kapoor Ashish , Mathur Kavita 
Published: November 2021

Abstract
The purpose of this parametric design of experiments was to identify and summarize how the influence of knit structure (single jersey vs. terry), fiber composition (polyester vs. cotton), fiber linear density (30/1 Ne vs. 18/1 Ne & 1/150/34 vs. 2/150/34), and yarn type (filament vs. spun) affected the frictional profile across the sock-skin interface, and then relate these factors to friction blister incidence. Friction testing trials were completed against both a polypropylene probe and a synthetic skin material (Lorica soft®) to determine if there was a difference in friction based on interface interaction. Friction testing was completed by sliding a probe across the inside bottom surface of the sock (the part that is usually in-contact with the bottom of the foot) while instantaneously measuring the frictional force every tenth of a second. For both trials (plastic probe and synthetic skin), in the dry condition, knit structure was found to be the most prominate fabric parameter affecting the frictional force experienced at the sock-skin interface. It was also determined that fiber linear density, and yarn type are tertiary factors affecting the frictional force measured at the sock-skin interface. Finally, in the dry state, it was determined that fiber composition had seemingly no effect on the frictional force experienced at the sock-skin interface.
US Local Public Health Department Spending Between 2008 and 2016 Did Not Increase for Communities in Need
Authors: Reszczynski Olivia , Connolly John , Shultz Kaitlyn , Kelly Sheila , Mitra Nandita , Hom Jeffrey , Venkataramani Atheendar , Chaiyachati Krisda H. 
Published: November 2021

Abstract
BackgroundGreater US local public health department (LPHD) spending has been associated with decreases in population-wide mortality. We examined the association between changes in LPHD spending between 2008 and 2016 and county-level sociodemographic indicators of public health need.MethodsMultivariable linear regression was used to estimate the association between changes in county-level per-capita LPHD spending and 2008 sociodemographic indicators of interest: percent of population that was over 65 years old, Black, Hispanic, in poverty, unemployed, and uninsured. A second model assessed the relationship between changes in LPHD spending and sociodemographic shifts between 2008 and 2016.ResultsLPHD spending increases were associated with higher percentage points of 2008 adults over 65 years of age (+$0.53 per higher percentage point; 95% CI: +$0.01 to +$1.06) and unemployment (+$1.31; 95% CI: -$2.34 to -$0.27). Spending did not increase for communities with a higher proportion of people who identified as Black or Hispanic, or those with a greater proportion of people in poverty or uninsured, using either baseline or sociodemographic shifts between 2008 and 2016.ConclusionFuture LPHD funding decisions should consider increasing investments in counties serving disadvantaged communities to counteract the social, political, and structural barriers which have historically prevented these communities from achieving better health.
Similarity Matrix-Based Anomaly Detection for Clinical Intervention
Authors: D’Mello Ryan , Melcher Jennifer , Torous John 
Published: November 2021

Abstract
The use of digital phenotyping methods in clinical care has allowed for improved investigation of spatiotemporal behaviors of patients. Moreover, detecting abnormalities in mobile sensor data patterns can be instrumental in identifying potential changes in symptomology. We propose a method that temporally aligns sensor data in order to achieve interpretable measures of similarity. These computed measures can then be used for anomaly detection, baseline routine computation, and trajectory clustering. In addition, we apply this method on a study of 695 college participants, as well as on a patient with worsening anxiety and depression. With varying temporal constraints, we find mild correlations between changes in routine and clinical scores. Furthermore, in our experiment on an individual with elevated depression and anxiety, we are able to cluster GPS trajectories, allowing for improved understanding and visualization of routines with respect to symptomology. In the future, we aim to apply this method on individuals that undergo data collection for longer periods of time, thus allowing for a better understanding of long-term routines and signals for clinical intervention.