bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the COVID-19 pandemic lockdown on rhegmatogenous retinal detachment services—Experiences from the Tongren eye center in Beijing
Authors: Li Jipeng , Zhao Meng , She Haicheng , Chandra Aman 
Published: August 2021

Purpose
To investigate the impact on services for rhegmatogenous retinal detachment (RRD) patients during the COVID-19 (2019coronal virus disease) pandemic in one tertiary center in Beijing.

Methods
A retrospective cohort study. Two reviewed consecutive RRD patients cohorts of the same length were treated during two different periods: the COVID-19 pandemic and the pre-COVID-19 group. The characteristics of patients, surgery, anesthesia methods, length of hospital stay, and the latest follow-up were recorded and analyzed.

Results
There were 79 patients in the COVID-19 pandemic group with a 55.9% reduction (179). Compared to patients in the pre-COVID-19, patients in the COVID-19 pandemic had a longer presurgical waiting times (28days, 3days, p<0.001), a higher percentage of patients with presurgical poor (less than 0.02) visual acuity (55.7%, 32.4%, p = 0.009), and a higher percentage of patients with presurgical choroidal detachment (34.2%, 19.6%, p = 0.01). There was no significant difference in the severity of presurgical proliferative vitreoretinopathy between the two groups (p = 0.64). Surgeries on pathological myopia patients with macular hole retinal detachment were postponed in the COVID-19 pandemic. There was a lower percentage of scleral buckling (27.8%, 41.3%, p = 0.02) and a lower rate of subretinal fluid drainage (45.4%, 75.7%, p = 0.01) in the COVID-19 pandemic. There was no significant difference in either postoperative visual acuity (p = 0.73) or the rate of single-surgery retinal attachment (p = 1) between the two groups. Patients in the COVID-19 pandemic had a shorter length of hospital stay (3hours, 35 hours, p<0.001), and a lower percentage of patients received general anesthesia (48.1%, 83.2%, p<0.001). None was infected with COVID-19 disease during the pandemic.

Conclusion
The COVID-19 pandemic lockdown caused prolonged presurgical waiting times, shorter hospital stays, less general anesthesia, and a significant reduction of RRD surgeries. The RD were more complicated, the surgeons were more conservative on procedures and patients selection, while the surgery outcomes were comparable.
COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab
Authors: Dimai Sanzio , Semmler Lukas , Prabhu Ashok , Stachelscheid Harald , Huettemeister Judith , Klaucke Sandra C. , Lacour Philipp , Blaschke Florian , Kruse Jan , Parwani Abdul , Boldt Leif-Hendrik , Bullinger Lars , Pieske Burkert M. , Heinzel Frank R. , Hohendanner Felix 
Published: August 2021

Background
Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for the concomitant cardiac dysfunction and associated arrhythmias is unclear. Moreover, the role of anti-inflammatory therapy to mitigate cardiac dysfunction remains elusive.

Aims and methods
We investigated the effects of COVID19-associated inflammatory response on cardiac cellular function as well as its cardiac arrhythmogenic potential in rat and induced pluripotent stem cell derived cardiomyocytes (iPS-CM). In addition, we evaluated the therapeutic potential of the IL-1β antagonist Canakinumab using state of the art in-vitro confocal and ratiometric high-throughput microscopy.

Results
Isolated rat ventricular cardiomyocytes were exposed to control or COVID19 serum from intensive care unit (ICU) patients with severe ARDS and impaired cardiac function (LVEF 41±5%; 1/3 of patients on veno-venous extracorporeal membrane oxygenation; CK 154±43 U/l). Rat cardiomyocytes showed an early increase of myofilament sensitivity, a decrease of Ca2+ transient amplitudes and altered baseline [Ca2+] upon exposure to patient serum. In addition, we used iPS-CM to explore the long-term effect of patient serum on cardiac electrical and mechanical function. In iPS-CM, spontaneous Ca2+ release events were more likely to occur upon incubation with COVID19 serum and nuclear as well as cytosolic Ca2+ release were altered. Co-incubation with Canakinumab had no effect on pro-arrhythmogenic Ca2+ release or Ca2+ signaling during excitation-contraction coupling, nor significantly influenced cellular automaticity.

Conclusion
Serum derived from COVID19 patients exerts acute cardio-depressant and chronic pro-arrhythmogenic effects in rat and iPS-derived cardiomyocytes. Canakinumab had no beneficial effect on cellular Ca2+ signaling during excitation-contraction coupling. The presented method utilizing iPS-CM and in-vitro Ca2+ imaging might serve as a novel tool for precision medicine. It allows to investigate cytokine related cardiac dysfunction and pharmacological approaches useful therein.
To what extent is telehealth reported to be incorporated into undergraduate and postgraduate allied health curricula: A scoping review
Authors: Hui Kay Yan , Haines Claudia , Bammann Sophie , Hallandal Matthew , Langone Nathan , Williams Ciara , McEvoy Maureen 
Published: August 2021

Background
Telehealth has become a necessity within the medical and allied health professions since the COVID-19 Pandemic generated a rapid uptake worldwide. It is now evident that this health delivery format will remain in use well into the future. However, health education training, most particularly allied health, has been slow to ‘catch up’ and adapt curriculum to ensure graduates are equipped with the knowledge and skills to implement telehealth in the workplace. The aim of this study was to gain a comprehensive understanding of current telehealth curricula in undergraduate and postgraduate allied health education training programs, with a focus on the aims, objectives, content, format, delivery, timeline and assessments.

Methods
A systematic search of Medline, Embase, PsychINFO, Scopus, ERIC and relevant grey literature was conducted. Students studying allied health degrees through formal education at either postgraduate or undergraduate level were included, while nursing, dentistry and medical students were excluded. The data from the included studies was extracted and tabulated by country, participants, program and content.

Results
Of the 4484 studies screened, eleven met the eligibility criteria. All studies were published after 2012, highlighting the recency of research in this area. The studies were conducted in four countries (Australia, United Sates of America, United Kingdom, Norway) and participants were from various allied health professions. Of the included studies, four related to undergraduate programs, four to postgraduate programs and for the remaining three, this was not specified. Curricula were delivered through a combination of online and face-to-face delivery, with assessment tasks, where reported, comprising mainly multiple-choice and written tests.

Conclusion
Published reporting of telehealth curricula within allied health programs is limited. Even the minority of programs that do include a telehealth component lack a systematic approach. This indicates that further primary research would be beneficial in this area.
Nationwide surveillance of AIDS-defining illnesses among HIV patients in Japan from 1995 to 2017
Authors: Tanaka Takeshi , Oshima Kazuhiro , Kawano Kei , Tashiro Masato , Tanaka Akitaka , Fujita Ayumi , Tsukamoto Misuzu , Yasuoka Akira , Teruya Katsuji , Izumikawa Koichi 
Published: August 2021

Objectives
The accurate prevalence of acquired immunodeficiency syndrome (AIDS)-defining illnesses (ADIs) in human immunodeficiency virus (HIV)-infected patients has not been well investigated. Hence, a longitudinal nationwide surveillance study analyzing the current status and national trend of opportunistic complications in HIV-infected patients in Japan is warranted.

Methods
A nationwide surveillance of opportunistic complications in HIV-infected patients from 1995 to 2017 in Japan was conducted. An annual questionnaire was sent to 383 HIV/AIDS referral hospitals across Japan to collect information (CD4+ lymphocyte count, time of onset, outcome, and antiretroviral therapy [ART] status) of patients diagnosed with any of 23 ADIs between 1995 and 2017.

Results
The response and case capture rates of the questionnaires in 2017 were 53% and 76%, respectively. The number of reported cases of opportunistic complications peaked in 2011 and subsequently declined. Pneumocystis pneumonia (38.7%), cytomegalovirus infection (13.6%), and candidiasis (12.8%) were associated with the cumulative incidence of ADIs between 1995 and 2017. The mortality rate in HIV-infected patients with opportunistic complications substantially decreased to 3.6% in 2017. The mortality rate was significantly higher in HIV patients who received ART within 14 days of diagnosis of complications than in those who received ART 15 days after diagnosis (13.0% vs. 3.2%, p < 0.01).

Conclusions
We have demonstrated a 23-year trend of a newly diagnosed AIDS status in Japan with high accuracy. The current data reveal the importance of Pneumocystis pneumonia as a first-onset illness and that early initiation of ART results in poor outcomes in HIV patients in Japan.
New class of operators where the distance between the identity operator and the generalized Jordan ∗-derivation range is maximal
Authors: Messaoudene Hadia , Mesbah Nadia 
Published: August 2021

Abstract
A new class of operators, larger than

∗

\ast

-finite operators, named generalized

∗

\ast

-finite operators and noted by

Gℱ

∗

(

ℋ

)

{{\mathcal{G {\mathcal F} }}}^{\ast }\left({\mathcal{ {\mathcal H} }})

is introduced, where:

Gℱ

∗

(

ℋ

)

=

{

(

A
,
B

)

∈
ℬ

(

ℋ

)

×
ℬ

(

ℋ

)

:

∥

T
A
−
B

T

∗

−
λ
I

∥

≥

∣

λ

∣

,

∀

λ
∈
C
,

∀

T
∈
ℬ

(

ℋ

)

}

.

{{\mathcal{G {\mathcal F} }}}^{\ast }\left({\mathcal{ {\mathcal H} }})=\{(A,B)\in {\mathcal{ {\mathcal B} }}\left({\mathcal{ {\mathcal H} }})\times {\mathcal{ {\mathcal B} }}\left({\mathcal{ {\mathcal H} }}):\parallel TA-B{T}^{\ast }-\lambda I\parallel \ge | \lambda | ,\hspace{0.33em}\forall \lambda \in {\mathbb{C}},\hspace{0.33em}\forall T\in {\mathcal{ {\mathcal B} }}\left({\mathcal{ {\mathcal H} }})\}.

Basic properties are given. Some examples are also presented.
Implication of nitrergic system in the anticonvulsant effects of ferulic acid in pentylenetetrazole-induced seizures in male mice
Authors: Amini-Khoei Hossein , Nasiri Boroujeni Shakiba , Lorigooini Zahra , Salehi Arash , Sadeghian Reihaneh , Rahimi-Madiseh Mohammad 
Published: August 2021

Abstract

Objectives
Seizures are abnormal discharge of neurons in the brain. Ferulic acid (FA) is a phenolic compound with antioxidant and neuroprotective effects. The present study aimed to investigate the role of the nitrergic system in the anticonvulsant effect of FA in pentylenetetrazol (PTZ)-induced seizures in male mice.

Methods
64 male Naval Medical Research Institute (NMRI) mice weighing 25–29 g were randomly divided into eight experimental groups (n=8). FA at doses 5, 10, and 40 mg/kg alone and in combination with L-nitro-arginine methyl ester (L-NAME) (nitric oxide synthase inhibitor) or L-arginine (L-arg) (nitric oxide [NO] precursor) was administrated (intraperitoneal). PTZ was injected (i.v. route) 30 min after drugs administration (1 mL/min). Seizure onset time was recorded and the nitrite levels of prefrontal cortex and serum were determined by the Griess method.

Results
FA at doses of 10 and 40 mg/kg significantly increased the seizure threshold as well as reduced the serum and brain NO levels in comparison to the saline-received group. Co-administration of the effective dose of FA (10 mg/kg) plus L-arg significantly decreased the seizure threshold in comparison to the effective dose of FA alone. Co-injection of the sub-effective dose of FA (5 mg/kg) with L-NAME significantly increased the seizure threshold as well as significantly decreased the brain NO level in comparison to the sub-effective dose of FA alone.

Conclusions
We showed that the nitrergic system, partially at least, mediated the anticonvulsant effect of FA in PTZ-induced seizures in mice. We concluded that L-NAME potentiated while L-arg attenuated the anticonvulsant effect of FA.
Cardiotocographic features in COVID-19 infected pregnant women
Authors: Sinaci Selcan , Ocal Doga Fatma , Ozden Tokalioglu Eda , Halici Ozturk Filiz , Aydin Senel Selvi , Keskin Levent Huseyin , Moraloglu Tekin Ozlem , Sahin Dilek 
Published: August 2021

Abstract

Objectives
We aimed to evaluate the cardiotocograph (CTG) traces of 224 women infected with novel coronavirus 2019 (COVID-19) and analyze whether changes in the CTG traces are related to the severity of COVID-19.

Methods
We designed a prospective cohort study. Two-hundred and twenty-four women who had a single pregnancy of 32 weeks or more, and tested positive for SARS-CoV-2 were included. Clinical diagnosis and classifications were made according to the Chinese management guideline for COVID-19 (version 6.0). Patients were classified into categories as mild, moderate, severe and the CTG traces were observed comparing the hospital admission with the third day of positivity.

Results
There was no statistically significant relationship between COVID-19 severity and CTG category, variability, tachycardia, bradycardia, acceleration, deceleration, and uterine contractility, Apgar 1st and 5th min.

Conclusions
Maternal COVID-19 infection can cause changes that can be observed in CTG. Regardless of the severity of the disease, COVID-19 infection is associated with changes in CTG. The increase in the baseline is the most obvious change.
Characterization of polystyrene and polyacrylic based polymeric materials exposed to oxidative degradation
Authors: Singare P. U. 
Published: August 2021

Abstract
The characterization of oxidative degraded polystyrene-based resin (R1) and polyacrylic based resin (R2) resins in H2O2 and HClO4 degradation medium were made based on the kinetics and thermodynamic data obtained for the ion-isotopic exchange reactions using such resins. For the reactions performed by using resins degraded in H2O2 medium, the reaction rate (k) values obtained for the fresh R1 (0.315 min–1) and R2 (0.187 min–1) resins decreases to 0.300 and 0.155 min–1 respectively for the resins degraded in 20% H2O2 medium, which further decreases to 0.289 and 0.142 min–1 respectively for the resins degraded in 30% H2O2 medium. A similar trend in the results were observed for the reactions performed by using the above resins degraded in HClO4 medium. The higher values of k (min–1) and low values of various thermodynamic parameters for the ion-isotopic exchange reactions performed by using fresh and degraded polystyrene-based resin R1 resins suggests superior degradation stability as compared to polyacrylic based R2 resin.
Against Global Literary Studies
Authors: Edmond Jacob 
Published: August 2021

Abstract
Literary studies has taken a global turn through such institutional frameworks as global romanticism, global modernism, global anglophone, global postcolonial, global settler studies, world literature, and comparative literature. Though promising an escape from parochialism, nationalism, and Eurocentrism, this turn often looks suspiciously like another version of Anglo-European imperialism. This essay argues that, rather than continue the expansionary line of recent decades, global literary studies must allow other perspectives to draw into question its concepts, practices, and theories, including those associated with the terms literature, discipline, and comparison. As a settler colonial (Pākehā) scholar in Aotearoa New Zealand, I attend particularly to Māori literary scholars from Apirana Ngata, Te Kapunga Matemoana (Koro) Dewes, and Hirini Melbourne to Alice Te Punga Somerville, Tina Makereti, and Arini Loader. Their work highlights the limitedness of global literary studies in its current disciplinary guise. Disciplines remain important when they bring recognition to something previously marginalized, as in the battle to have Māori literature recognized within Pākehā institutions. What institutionalized modes of global literary studies need, however, is not discipline but indiscipline: a recognition of the limits of dominant disciplinary objects, frameworks, and practices, and an openness to other ways of seeing the world.
Towards a Systematic Approach to Digital Technologies for Heritage Conservation. Insights from Jordan
Authors: Trillo Claudia , Aburamadan Rania , Mubaideen Shatha , Salameen Dana , Makore Busisiwe Chikomborero Ncube 
Published: August 2021

AbstractConsensus exists on the importance of heritage for ensuring sustainable futures, due to its impact on political aspects, ethical reflection and local economic development. Nowadays, using technology has become crucial in the construction industry, including heritage conservation. This paper aims to compare a selected sample of digital platforms, gathering data in support of heritage documentation, both for heritage and archeological sites. Despite the huge potential of digital technologies for contributing to heritage conservation, still there is a need for more clarity on what should be used to achieve different goals and what is the best approach under various circumstances. A team of five experts on digital technologies applied to different types of heritage worked collaboratively to gather the case studies in this paper and to analyse them comparatively. Jordan is a Middle East and North Africa country chosen as unit of analysis, because of the huge potential of digital technologies for heritage documentation. The findings from the comparative case review offers a reflection on what should best adopted for achieving different goals. Differences of approaches were revealed between the characteristics of heritage site and those of archaeological sites in Jordan’s conservation history. The findings called for a prioritization of using digital technology in both heritage and archeological sites. The discussion on digital platforms currently available in Jordan allows for highlighting strengths and limitations of different approaches and methodologies, thus drawing lessons for addressing the strategic choice of the most appropriate digital solution under different circumstances and in different contexts.
Review on technologies to separate and purify ethyl alcohol from dilute aqueous solutions
Authors: Sanap Pooja P. , Mahajan Yogesh S. 
Published: August 2021

Abstract
Ethyl alcohol (ethanol) is viewed upon as a fuel additive or even as an alternative fuel. Fermentation is used to produce dilute (<20 mass%) ethanol. This is needed to be concentrated to almost anhydrous, fuel grade ethanol (>99.5 mass%). The technologies used for concentration from dilute grade to fuel grade ethanol are summarized in this review. Thus, extraction; distillation; use of membranes; adsorption and some miscellaneous methods are discussed in detail. For each technique, the inlet and outlet concentrations; merits and demerits and scope for future work are indicated. Hybrid separations are discussed. In addition to technical feasibility, economic viability of the techniques is also discussed. A brief discussion on current industrial practice is also presented.
Previous Motor Actions Outweigh Sensory Information in Sensorimotor Statistical Learning
Authors: Feulner Barbara , Postin Danilo , Schwiedrzik Caspar M. , Pooresmaeili Arezoo 
Published: August 2021

AbstractHumans can use their previous experience in form of statistical priors to improve decisions. It is, however, unclear how such priors are learned and represented. Importantly, it has remained elusive whether prior learning is independent of the sensorimotor system involved in the learning process or not, as both modality-specific and modality-general learning have been reported in the past. Here, we used a saccadic eye movement task to probe the learning and representation of a spatial prior across a few trials. In this task, learning occurs in an unsupervised manner and through encountering trial-by-trial visual hints drawn from a distribution centered on the target location. Using a model-comparison approach, we found that participants’ prior knowledge is largely represented in the form of their previous motor actions, with minimal influence from the previously seen visual hints. By using two different motor contexts for response (looking either at the estimated target location, or exactly opposite to it), we could further compare whether prior experience obtained in one motor context can be transferred to the other. Although learning curves were highly similar, and participants seemed to use the same strategy for both response types, they could not fully transfer their knowledge between contexts, as performance and confidence ratings dropped after a switch of the required response. Together, our results suggest that humans preferably use the internal representations of their previous motor actions, rather than past incoming sensory information, to form statistical sensorimotor priors on the timescale of a few trials.
Nakota: una trayectoria investigativa desde el conflicto armado hasta el emprendimiento
Authors: Rubio Pardo Diana Milena , Contreras Castro Daniel Alejandro , Florián Delgadillo Henry Ferrer , Castellanos Triviño Héctor Rafael 
Published: August 2021

El presente artículo constituye una mirada retrospectiva a los procesos de investigación, semilleros y que impulsaron la génesis del grupo de investigación Nakota de la Universidad Santo Tomás , en el que estudiantes estudiantes, docentes y egresados ​​de los CAU Villavicencio, Yopal, Facatativá, Chiquinquirá y Bucaramanga.Las intenciones y compromisos investigativos se han descrito por la articulación entre las funciones sustantivas de docencia, investigación y responsabilidad social, a través de tres líneas de investigación que involucran la educación, la infancia, el pensamiento filosófico, la resiliencia y el emprendimiento. Se dará cuenta de los proyectos que se han desarrollado en torno a los menores de edad víctimas del conflicto armado y cómo las metodologías no solo han permitido entender el fenómeno,