bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing the Interference for Down-Link in LTE Using Fractional Frequency Reuse
Authors: Ibrahim Ahmed , Al-Awamry A.Al-Awamry , Mohra Ashraf Shawky 
Published: March 2021

Long Term Evolution has developed a new radio technology called femtocell or Femto Base station, which is well-suited to improve cellular network capacity and mobile coverage to indoor user's areas. Providing additional capacity and coverage expansion through FBSs could lead to large interference in a cellular radio communication network. In this paper, we proposed an efficient resource allocation scheme based on Fraction Frequency Reuse (FFR) for interference mitigation, where the entire spectrum is shared among network entities. FFR mechanism aims to reduce co-tier and cross-tier downlink interferences by allocating non-overlapping sets of bands to the user equipment at different geographic locations. The main purpose of this work is to compare two main types of FFR schemes, respectively, Strict FFR and Soft Frequency Reuse with the proposed scheme. The three types of FFR schemes were explained and evaluated with Monte-Carlo simulation based on some performance metrics, namely, sum-rate, spectral efficiency, and outage probability. Simulation results showed that the impacts of the proposed scheme are significantly high in comparison with two other methods. The proposed scheme proved to enhance spectral efficiency, reduced the outage probability, and increased the sum rate for all the users.
Penerapan Sanksi Pidana terhadap Anak Pelaku Tindak Pidana Pencabulan
Authors: Prisdawati Renna , Zuhdy Mukhtar 
Published: March 2021

Pencabulan adalah semua perbuatan yang berkenaan dengan kehidupan di bidang seksual yang melanggar kesusilaan (kesopanan). Kitab Undang-Undang Hukum Pidana menggolongkan tindak pidana pencabulan kedalam tindak pidana kesusilaan. Tindak pidana pencabulan saat ini banyak terjadi dan sangat memperhatinkan. Anak yang melakukan tindak pidana sudah selayaknya jika diberikan sanksi yang disesuaikan dengan peraturan yang berlaku.Tujuan penelitian yang dilakukan penulis ini untuk mengetahui bagaimana penerapan sanksi pidana terhadap anak sebagai pelaku tindak pidana pencabulan. Jenis penelitian yang digunakan dalam penulisan ini menggunakan jenis penelitian normatif, yaitu menggunakan bahan kepustakaan, baik itu bahan primer, sekunder maupun tersier. Hasil penelitian menjelaskan bahwa upaya diversi tidak dapat dilakukan terhadap anak sebagai pelaku tindak pidana pencabulan. Sesuai dengan aturan dalam Pasal 7 ayat (2) Undang-undang Nomor 11 Tahun 2012 Tentang Sistem Peradilan Pidana Anak, syarat agar dapat dilakukan diversi hanya terhadap tindak pidana dengan ancaman pidana penjara dibawah tujuh tahun dan tindak pidana tersebut bukanlah pengulangan tindak pidana. Hal tersebut jelas tidak dapat diterapkan dalam tindak pidana pencabulan, karena tindak pidana pencabulan diancam dengan pidana penjara paling lama lima belas tahun
Peculiarities of pumpkin carotenoid composition ‘Konfetka’ variety, prospects of utilization
Authors: Golubkina N. A. , Khimich G. A. , Antoshkina M. S. , Plotnikova U. D. , Nadezhkin S. M. , Korottseva I. B. 
Published: March 2021

Relevance. Pumpkin is one of the most important source of carotenoids for humans: β- and α-carotene, lutein and zeaxanthin playing a fundamental role in providing twilight and color vision accordingly.Results. Investigation of pumpkin carotenoid composition, Konfetka variety, revealed for the first time that this cultivar is the only one containing exclusively lutein in pulp with lutein and zeaxanthin in peel and lutein, zeaxanthin and β-carotene in placenta. Lutein concentration in pulp reached 11 mg/100 g, peel – 41.3/100 g, placenta – 51.2 mg/100 g. Zeaxanthin was absent in pulp and reached 28.3 mg/100 g in peel, and 10 mg/100 g in placenta. β-Carotene was detected only in placenta where its concentration was as much as 94.7 mg/100 g. The results indicate great prospects of ‘Konfetka’ components utilization (pulp, peel, placenta) in food industry, production of baby food and biologically active food additives, containing lutein and zeaxanthin.
Influence of storage conditions on the quality of jerusalem artichoke
Authors: Mudrykh N. M. , Semakova S. A. 
Published: March 2021

Relevance. Jerusalem artichoke is a culture that has recently received a lot of attention. It is used to prepare highly effective medicines, fruit and vegetable drinks and purees, and is also used in cooking. The issue of preserving Jerusalem artichoke tubers as a raw material source, a promising direction in the technology of functional products. The purpose of the research is to determine the influence of temperature storage regimes on the preservation of consumer qualities of Jerusalem artichoke tubers.Materials and methods. The object of research is Jerusalem artichoke tubers (Helianthus tuberosus L.). Plants were grown in the Perm region of the Perm kray. Tubers before being stored were sorted, washed, dried and placed in polymer bags. The test samples were stored at three temperature regime: -22…-18°C, 0…4 and 18…22°C for 3 months. Samples were taken every 30 days. The quality was assessed by organoleptic parameters, dry matter content, total sugar, inulin and vitamin C. Construction of models for predicting the quality indicators of Jerusalem artichoke was carried out on the basis of structural relationships with storage conditions, which were established using two approaches: correlation and information-logical.Results. Organoleptic parameters of tubers of the studied samples met the requirements of GOST 32790-2014. The mass fraction of total sugar and vitamin C at 18…22°C decreased relative to the initial content by 10.8 and 57.8%. Storage of tubers is accompanied by a decrease in inulin, and after three months, its mass fraction was lower than the original by 61.9 %. Using correlation analysis, linear structural relationships between quality indicators and storage conditions were established, according to which the content of carbohydrates and vitamin C primarily depends on the temperature regime (r=-0.8-0.4), and secondly – on the storage conditions term (r =-0,3-0,3). The use of the information-logical method allowed us to confirm the established correlation relations. The obtained adequate models for predicting the level of quality characteristics of tubers, depending on the storage period and temperature regime, allow you if necessary to quickly change the storage conditions. The analysis made it possible to identify the optimal term and temperature regime of storage of tubers.
Factors Associated With Self-Care Among Patients Receiving Hemodialysis: A Cross-Sectional Observational Study
Authors: Lee Juhyun , Noh Dabok 
Published: March 2021

Background and PurposeThe global increase in prevalence of individuals with
end-stage renal disease is a rising concern. Self-care is an essential and important component of chronic disease management. Poor self-care in patients receiving hemodialysis is associated with an increased risk of mortality and hospitalization. This study aimed to identify predictive factors for self-care in patients receiving hemodialysis based on a middle-range theory of self-care for chronic illness.MethodsAdult patients with end-stage renal disease receiving hemodialysis were recruited at an artificial kidney unit in a general hospital. Data from 131 patients were analyzed. Self-report questionnaires assessed hemodialysis-related knowledge, health motivation, self-efficacy, social support, access to care, and self-care.ResultsParticipants who had a family caregiver showed significantly higher selfcare scores than those who did not, and self-care scores were higher in patients who reported hypertension as a causal disease of end-stage renal disease than in those who did not. Self-care was significantly correlated with knowledge, health motivation, self-efficacy, social support, and access to care. The study’s regression model showed that self-efficacy, health motivation, and knowledge were predictive variables influencing self-care, and the explanatory power of this model was 55.9%.Implications for PracticeThe results support the middle-range theory of self-care for chronic illness. Strategies and education to improve self-efficacy, health motivation, and knowledge must be incorporated when designing self-care programs. Nursing interventions that patients can participate in with their family members might facilitate improving self-care.
Pilot Testing and Psychometric Validation of the Nijmegen Professionalism Scale for Spanish Nursing
Authors: García-Moyano Loreto , Altisent Rogelio , Delgado-Marroquín María Teresa , Pellicer-García Begoña , Arrazola-Alberdi Oihana , Antón-Solanas Isabel 
Published: March 2021

Background and PurposeProfessional commitment is frequently used as a humanistic care indicator. Thus, it is important to design and validate a tool which is able to measure professional commitment of nurses in Spain. In this study we aimed to analyze the psychometric properties of the Nijmegen Professionalism Scale for Spanish (NPS-S) nursing in order to verify its validity and reliability.MethodsWe undertook the pilot testing and psychometric validation of the NPS-S. A total sample of 249 nursing professionals from a variety of areas of expertise took part in this study. The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) Statement was used for reporting this research.ResultsThe NPS-S achieved a high degree of content validity, construct validity, internal consistency, temporal stability, and usability; this version is, thus, equivalent to the Nijmegen Professionalis Scale in its original version.Implications for PracticeBased on the results obtained from the validation of this tool, it is possible to affirm that the NPS-S is an effective instrument for measuring professional commitment in this population. The NPS-S will evaluate and thus contribute to the promotion of professional commitment in Spanish nursing. Additionally, it will serve to establish correlations between professional commitment and other variables including quality of care and patient satisfaction. Future studies should analyze the evaluation capacity of this tool.
The Process of Injection Drug Use Among Homeless Women in Ottawa, Canada: A Qualitative Study
Authors: Kitson Cynthia , O’Byrne Patrick 
Published: March 2021

BackgroundThe literature on women who use injection drugs (WUIDs) is antiquated and diluted by data from men. Due to the higher rates of morbidity and mortality among WUID, we undertook a qualitative study to better understand their drug use practices.MethodsWe adopted a Deleuze–Guattarian lens and engaged in semi-structured interviews with 35 women in Ottawa, Canada. Data from 31 of these women were analyzed using applied thematic analysis.ResultsWe divided these themes into (a) how WUID obtain resources to acquire drug,and (b) the steps involved in preparing, using, and discarding drugs. From our Deleuzo–Guattarian perspective, these findings highlighted that participants stratified their worlds according to rules of cleanliness to create hierarchies of appropriateness and acceptability.ConclusionsThese findings, overall, highlight the importance of understanding the constructed world of WUIDs, particularly regarding the ways in which nurses interact with these women to provide care.
Transforming Growth Factor β1 and Myocardial Remodeling in Patients with Chronic Heart Failure of Ischemic Genesis
Authors: Zakirova N. E. , Zakirova A. N. , Nizamova D. F. 
Published: March 2021

Aim. To study the presence and nature of correlations between the level of transforming growth factor β1 (TFR-β1) and structural and functional parameters of the heart in the development of myocardial remodeling and fibrosis in patients with chronic heart failure (CHF) of ischemic origin.Material and methods. The study included 120 men with class II-IV CHF who have history of myocardial infarction, which are divided into 3 groups depending on the CHF class. The control group included 25 healthy men. Assessment of left ventricular (LV) structural-functional state was carried out by echocardiography. Investigation of TFR-β1 and N-terminal precursor indices of cerebral natriuretic peptide (NT-pro BNP) was performed by enzyme immunoassay.Results. Patients with class II-IV CHF were hyperexpression of ТФР-β1, the levels of which increased significantly as NYHA class increased and CHF progressed. The most significant structural-geometric rearrangement of LV and hyperactivation ТФР-β1 recorded in patients with class IV CHF (77.2±6.33 ng/ml with class IV CHF versus 46.7±3.74 ng/ml and 58.9±4.75 ng/ml with class II and III CHF; р< 0.05). In patients of class III-IV CHF, correlation relationships between ТФР-β1 level and echocardiographic parameters (LV myocardial mass index are established: r = 0.56, p = 0.05; end systolic volume index: r = 0.52, p = 0.05; value of LV ejection fraction: r = -0.48, p=0,05). Significant direct relationships are established in patients with class III-IV CHF between ТФР-β1 level and NT-rgo BNP levels (r=0,44; р=0,05).Conclusion. The intensity of myocardial remodeling and fibrosis processes in patients with a progressive course of CHF is related to ТФР-β1 hyperexpression and is associated with a high level of activity of natriuretic peptides.
Mean States and Future Projections of Precipitation Over the Monsoon Transitional Zone in China in CMIP5&nbsp;and CMIP6 Models
Authors: Piao Jinling , Chen Wen , Chen Shangfeng , Gong Hainan , Wang Lin 
Published: March 2021

Abstract
The mean states and future projections of precipitation over the monsoon transitional zone (MTZ) in China are examined based on the historical and climate change projection simulations from phase 5 and phase 6 of the Coupled Model Intercomparison Project (CMIP5 and CMIP6, respectively). Ensemble means of CMIP6 models exhibit a clear improvement in capturing the annual mean and seasonal cycle of the precipitation over the MTZ, both in its spatial pattern and magnitude, compared to the counterparts of CMIP5 models. In addition, both CMIP5&6 models project a significant increase in the annual total precipitation amount and annual precipitation range, but with slightly stronger changes in CMIP6. For the climatological mean precipitation amount, the two versions’ model ensembles show high consistency in the substantial role played by local evaporation in the supply of moisture in both the present-day and future-projection scenarios, with little contribution from the horizontal and vertical advection of moisture. The precipitation amount is projected to increase in all seasons, but with the strongest signals in summer. An analysis of the moisture budget indicates that the increase in summer precipitation is mainly due to evaporation and vertical moisture advection changes in both CMIP5&6 models. However, the change in vertical moisture advection in CMIP5 is primarily attributable to the thermodynamic effects associated with the humidity changes. By contrast, the dynamic effects induced by the atmospheric circulation changes play a dominant role for CMIP6, which is likely related to the stronger warming gradient between the mid–high latitudes and the tropics.
Decompression Effects on Suppurative and Sclerosing Osteomyelitis in the Jaw
Authors: Sodnom-Ish Buyanbileg , Eo Mi Young , Oh Ji Hye , Seo Mi Hyun , Yang Hoon Joo , Lee Jong Ho , Kim Soung Min 
Published: March 2021

Abstract
Background: Osteomyelitis (OM) of the jaw is usually caused by a chronic odontogenic infection. Decompression is the release the intraluminal pressure in the cystic cavity allowing gradual bone growth from the periphery. The aim of this study was to analyze the effectiveness of decompression in an OM jaw model.Methods: A 4-mm-diameter defect was made on mandibles of fourteen Sprague-Dawley rats and inoculated with S. aureus (20 μl of 1x107 CFU/ml) injection. Two weeks later, four groups were made as non-treatment (C1), only curettage (C2), curettage and decompression (E1), and curettage and decompression with normal saline irrigation (E2). After four weeks, each group was analyzed.Results: Most micro-CT parameters of C1 and C2 were significantly lower, and bone mineral density with bone volume was enhanced in E2. E1 and E2 groups in histology showed prominent bone healing with a significantly high number of osteocytes, E2 had the weakest expression of IL-6 compared to that of C1. TNF-α and OPN were expressed strongly in the E1.Conclusion: Decompression drains induced advanced bone healing compared to that of curettage alone in an OM jaw model. Therefore, it could be recommended to use decompressive drain for the enhancement of jaw OM management.
Redesign of an innovative new extrusion system for a printing machine for ceramics
Authors: Mesbahi Jihad EL , Corral Irene Buj , Mesbahi Abdelilah EL 
Published: March 2021

Abstract
Today, the introduction of ceramic materials in the medical field is becoming a vital necessity because of its stable physicochemical characteristics, high biocompatibility, and good osteoconductivity. On the other hand, machining of ceramic components is difficult, owing to their extreme hardness and brittleness. Additive Manufacturing (AM) technologies are an appropriate alternative to obtain the complex shapes of implants, which can have porous structures. Thus, since the development of 3D printing, Direct Ink Writing (DIW) is one of the most promising and inexpensive techniques for shaping free-form ceramic medical components such as prostheses or dental implants from liquids or pastes. However, the assurance of performance criteria of the extrusion system for simultaneous usage becomes the major challenge for most Direct Ink Writing (DIW) platforms, for instance for printing large parts, for multi-material printing, to decrease printing time, and to increase efficiency in terms of motor usage and weight of the extruders. To address the current deficiencies, a new extrusion system is redesigned for a 3D printing machine for ceramics that is compatible with different low-cost, open-source 3D printers. The proposed extrusion model enables printing with a loader with different syringes simultaneously, without stopping the operational process while switching the syringe. Pugh concept analysis was used to select the optimum design shape. After that, the 3D CAD environment was used to combine the strength of Pugh’s method and the design space. This brings a new concept into the mechanical design field for 3D printers, which is in line with the technological trends prevalent in industry.
Glycemic Control by Umbilical Cord-Derived Mesenchymal Stem Cells Promotes Effects of Fasting-Mimicking Diet on Type 2 Diabetes
Authors: Zhao Na , Gao Ying-Feng , Bao Lei , Lei Jing , An Huan-Xiao , Pu Feng-Xing , Cheng Rui-Ping , Chen Ji , Ni Hua , Sui Bing-Dong , Ji Fan-Pu , Hu Cheng-Hu 
Published: March 2021

Abstract
Background Hepatic steatosis is a big hurdle to treat type 2 diabetes (T2D). Fasting-mimicking diet (FMD) has been shown to be an effective intervention in dyslipidemia of T2D. However, fasting might impair the normal glucose metabolism. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) transplantation has been discovered to regulate immune reactions and reduce hyperglycemia in diabetes. However, the effects of UC-MSCs on improving the lipid metabolism disorder are not quite satisfactory. We have investigated the efficacy comparison and interaction between two typical therapies of FMD and UC-MSC infusion, aiming to pave an avenue for their synergistic use, establish effective T2D therapies and explore its mechanism.Methods C57/BL6 mice were fed with high-fat diet (HFD) for 16 weeks to induce a diet-induced obese (DIO) mouse model. Six-week-old leptin-receptor-deficient (db/db) mice were used for follow-up experiments. DIO or db/db mice were divided into 4 groups: PBS, UC-MSCs (1*106), FMD (entails 4-day FMD and 7-day of refeeding (RF)) and UC-MSCs + FMD. At the end of the study period, mice were fasted for 6 h with the measurement of blood glucose and body weight, and then sacrificed. Blood was collected to determine levels of HbA1c, serum insulin, and cytokines. In addition, the fresh liver, skin and white adipose tissue were analyzed by histology.Results FMD restored the lipid metabolism in DIO mice, whereas its capacity to rescue hyperglycemia was uncertain. Infusion of UC-MSCs was effective in T2D glycemic control but the impact on dyslipidemia was insufficient. Furthermore, both the glucose and the lipid alterations of DIO and db/db mice recovered after UC-MSCs combined with FMD. It was proved that UC-MSCs promoted FMD effects on ameliorating hyperglycemia and restoring the lipid metabolism in T2D mice, while FMD had little promotion effect on UC-MSCs. Mechanistically, we discovered that UC-MSC infusion significantly modulated systematic inflammatory microenvironment, which contributed to concerted actions with FMD.Conclusions We established a strategy that combined UC-MSC infusion and FMD were effective in treating T2D, which synergistically attenuated hyperglycemia and improved the lipid metabolism through immunoregulation. The significance of the work is to provide potential approaches for developing novel clinical T2D therapies.
Identification of 3-miRNA Signature for Predicting Prognosis in Patients with Hepatocellular Carcinoma
Authors: Qiu Xinze , Wu Jiangni , Huang Zichen , Luo Shibo , Huang Jiean , Liu Shiquan 
Published: March 2021

Abstract
Background: Vascular invasion is closely related to the prognosis of hepatocellular carcinoma (HCC). Increasing evidence suggests that miRNAs can serve as biomarks to predict prognosis in various tumors. Thus, the aim of this study was to develop a novel, vascular invasion-related miRNA signature for prediction of HCC prognosis.Methods: Differentially expressed miRNAs (DEMs) between HCC samples with vascular invasion and without vascular invasion were obtained from GSE67140. MiRNAs expression profiles and clinical information for 344 patients were collected from The Cancer Genome Atlas database, and the patients were randomized (1:1) to training set and validation set. LASSO regression model was employed to identify survival-associated DEMs and establish risk score in the training set. Moreover, risk score was verified in the validation set. And nomogram based on risk score and clinical information was constructed to improve the prediction of prognosis. Meanwhile, four online tools were used to predict target genes and enrichment analysis was utilized to explore the biological pathway of the miRNAs.Results: A novel three-miRNA signature was screened including hsa-mir-210, hsa-mir-149 and hsa-mir-99a, and risk score was established for HCC prognosis prediction. Patients were divided into the low-risk group and high-risk group according to risk score. High-risk group both have higher hazard of death compared with low-risk group in training set and validation set. And the 5-year AUC of risk score were 0.718, 0.674 and 0.697 in training set, validation set and the total set, respectively. The C-index of nomogram was 0.724, and calibration curves showed nomogram had high concordance to predict 1- ,3- , and 5-year survival rates among HCC patients. Furthermore, enrichment analysis identified several tumor-associated pathways including Ras signaling pathway, PI3K-Akt signaling pathway, and MAPK signaling pathway and so on, which may contribute to explain the potential molecular mechanisms of above miRNAs.Conclusion: This study developed a risk assessment model based on three miRNAs, which could accurately predict the prognosis of HCC.