bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming barriers to HIV pre-exposure prophylaxis (PrEP) coverage in Australia among Medicare-ineligible people at risk of HIV: results from the MI-EPIC clinical trial
Authors: Chan Curtis , Fraser Doug , Vaccher Stefanie , Yeung Barbara , Jin Fengyi , Amin Janaki , Dharan Nila J. , Carr Andrew , Ooi Catriona , Vaughan Matthew , Holden Jo , Power Cherie , Grulich Andrew E. , Bavinton Benjamin R. 
Published: December 2021

Background Overseas-born people who are ineligible for government-subsidised health care experience barriers to accessing HIV pre-exposure prophylaxis (PrEP) in Australia. This study aimed to assess a program providing free PrEP to overseas-born adults at risk of acquiring HIV. Methods Medicare-Ineligible Expanded Implementation in Communities (MI-EPIC) was a single-arm, open-label trial of daily tenofovir disoproxil fumarate/emtricitabine as PrEP. Six clinics recruited Medicare-ineligible adults who met HIV risk criteria in New South Wales, Australia. We recorded data on HIV and sexually transmitted infection (STI) diagnoses, and PrEP dispensing from July 2019 to June 2020. PrEP adherence as a medication possession ratio (MPR) was calculated as pills dispensed divided by days. We administered an optional survey on behaviours and attitudes to PrEP and sexual health. Results The 221 participants (206 men; 93.2%) had a median age of 29 years (IQR 26–34). Participants were mostly born in Asia (53.4%), Latin America or the Caribbean (25.3%), or Europe (10.9%). Adherence was high; 190 participants (86.0%) had an MPR of >60%. Of 121 survey participants, 42 (34.7%) completed the survey in a language other than English. Of participants who had not used PrEP in the 6 months before enrolment (n = 45, 37.2%), the most common reasons were cost (n = 22, 48.9%), and lack of knowledge about accessing PrEP (n = 20, 44.4%). Conclusions Medicare-ineligible people at risk of HIV demonstrate high adherence when given access to free PrEP and translated information. Increasing PrEP awareness and reducing barriers to accessing PrEP in this high-risk population should be priorities in HIV prevention.
How infrastructure contributes to fostering Regional Innovation System: The case of Pelalawan Regency – Indonesia
Authors: Kusharsanto Z S , Maninggar N , Suhandojo  , Maulidya D , Muzaki A R 
Published: December 2021

Abstract
Regional Innovation System (RIS) has been regarded by many regions in Indonesia as part of their smart development strategy. The system comprises various elements to be harmonised, including the urban infrastructure. However, despite its essential role in the system, how urban infrastructure contributes to the development of RIS is still unclear and needs to be measured. This paper tries to shed light on the role of urban infrastructure in RIS implementation especially its impact on the operationalization of local institutions and economic development. The case of Pelalawan Regency is examined where RIS has been implemented there since 2015. The mixed method is conducted to assess Pelalawan’s most prominent infrastructure, information and communications technology (ICT) and water supply system, by carrying out survey to Pelalawan’s government agencies and followed by deep interviews to validate it. The result shows that infrastructure only contributes less than 50% encouraging the ideal RIS development, in which ICT’s role outperforms the other.
Revitalization of property asset on the Dumilah Waterpark through the infill development of new activities
Authors: Santoso E B , Siswanto V K , Sulistyandari U 
Published: December 2021

Abstract
Property assets owned by the city government should provide high benefits as a source of regional income. The asset is aging so that its productivity will decrease. The government is trying to revitalize assets to make them more productive. The purpose of this study is to determine the best utilization that can provide the highest benefit. The method used to assess the development of these assets is through the high best use approach. Several alternatives to the use of assets compared with the analysis of financial feasibility include the calculation of IRR, NPV, PP, ROI. The utilization of property assets that is more profitable for landowners, based on the results of the FGDs that have been carried out there is an opportunity to build a supporting facility for the development of Dumilah Water Park as a Hotel and Convention Hall. Both of these facilities have considerable economic appeal to support the function of the city of Madiun as a center for trade and services on a regional scale. Based on the calculation of financial feasibility at Dumilah Water Park with an initial investment amount of Rp. 60,354,000,000.00 then the Net Present Value is obtained of Rp. 6,258,119. Likewise, the Internal Rate of Return was obtained at 11.41%, greater than the 10% interest rate. Meanwhile, the Payback Period of this investment is 8 years with an ROI of 10%.
Using confirmatory factor analysis to evaluate the factor determining the bus usage in Surabaya City, Indonesia
Authors: Larasati A F , Handayeni K D M E 
Published: December 2021

Abstract
Surabaya City is second biggest city in Indonesia which has a vital public transportation called as Suroboyo Bus. The city bus system provides route to connect the northern and southern part of the city with the central business district in the city centre. Policy of developing city bus system in north-south corridor aims to encourage the shifting of automobile to bus use as the traffic congestion is mainly caused by the high dependent of private mobility. The operation of Suroboyo Bus has been a concern because of the attractiveness of the quality with low deck and double-deck bus types, Suroboyo Bus also equipped a priority area, as well as a unique payment system with plastic bottle waste. This study aims to investigate the factors which influence the preference of Suroboyo Bus based on the user’s perceptions. Thus, the city bus system can be evaluated to achieve sustainable city mobility. Using the method of Confirmatory Factor Analysis (CFA), the result shows that there are nine significant factors determining the use of Suroboyo Bus. The city bus usage is mostly influenced by the user characteristic and the service performance of the mode offered.
The sustainability concept of Malay Kampong as tourism destination and urbanheritage in Semarang: dualism of modern transformation versus heritage
Authors: Ristianti N S , Kurniati R , Widjajanti R 
Published: December 2021

AbstractThe dualism of heritage kampong and urban physical development led to the excistence. One of the effort is maintaining kampong existence into a cultural tourism. Such as Malay Kampong, as a historical tourist destination in Semarang. However, the community has not been able to develop tourism potential. They have a high dependence on the government. Besides, people who are not yet powerless will be fundamental determinants of the program’s sustainability. This research aims to formulate a sustainability model of the heritage kampong preservation as a tourist destination of Malay Kampong Semarang. The research method is qualitative descriptive. The first stage is the identification of historical tourism potential. The second stage is formulating the development trend in the context of dualism. The third stage is formulating the concept of the sustainability of historical tourism villages based on dualism. The fourth stage is formulating a sustainability model of heritage kampong based on environmental, economic, and social aspects. Based on the environmental aspect, the ethnic cultural as a new potential of tourist destination and cooperation with investors. Based on the economic aspect, the development of local products and training. Based on the social aspect, the development of cultural tourism community.
Ekistics in plannned and unplanned settlement
Authors: Novitasari V , Hardiyati  , Miladan N 
Published: December 2021

Abstract
Doxiadis (1969) in ekistics states that settlements are where people life and existence. Ekistics is one of the efforts that must be made to address the increasingly complex problems due to the increasing population growth and increasing land use Therefore, a settlement consists of the content (the content) that is human and where the physical human lives that include natural and man-made elements (the container). The formation of settlement morphology consists of planned and unplanned settlements, the method used in ekistics research in planned and unplanned settlements is the study of literature with descriptive analysis. Sampling used in this study is a planned settlement Kelurahan Baluwarti in Solo and an unplanned settlement that is a Kelurahan Gentan in kabupaten Sukoharjo. The result of this study is (1) The Concept of Ekistics exists in planned or unplanned settlements (2) The very noticeable difference between planned and unplanned settlements is the social condition of the community.
Sustainable Development Goals for settlement around Lapindo mudflow
Authors: Nurafiah I , Sunoko K , Handayani K N 
Published: December 2021

Abstract
The Lapindo mudflow in the Porong area, Sidoarjo Regency has been 14 years old since it first occurred on May 29, 2006. The biggest loss from the Lapindo mudflow is the damage to infrastructure and residents’ homes which has an impact on the slowing down of Sidoarjo’s economy. One of the efforts made by the government is to establish a National Action Plan (RAN) for disaster risk reduction (PRB) as an effort to achieve the Sustainable Development Goals (SDGs). Considering that the Lapindo mudflow is still active and the expiration time cannot be estimated, a long-term management strategy is needed in settlements around the location that are adaptive to the existence of the disaster. The research was carried out using qualitative-descriptive methods. Data collection techniques are carried out by interview, observation and documentation study. The data obtained is then matched with the indicators for assessing the Sustainable Development Goals (SDGs). The results of the research will provide insights in the form of settlement strategies carried out by local governments and communities as part of sustainable development in accordance with the conditions of their respective regions.
City thematic approach to achieve liveable city: case study of Bandung City
Authors: Sutriadi R , Noviansyah A 
Published: December 2021

Abstract
Livable City has been the goal for many cities and has become the one purpose of city planning. Nowadays, the need to achieve the livable aspects of the city resurfaced as an issue highlighted in Sustainable Development Goals. This brings focus on the index of livability, which tried to measure how livable the city is. The Indexes, however, did not instruct the correct directions to achieve the index. Various approaches have been done to satisfy the index of the livable city—where city thematic becomes one of the alternatives. Along with the common goals of achieving not only livable but also a sustainable city, the city thematic approach also raises many unique perks for solving urban problems. Although when the goals have always been the same, the approach might be slightly different. This paper explains that although there are several ways to achieve a livable city, the thematic city approach may be considered as an effective way to raise awareness of uncommon livability problems, and therefore one of the interesting approaches to be focused on.
Land use change trend of paddy field and its influence on food security in Gerbangkertosusila Region
Authors: Firmansyah F , Susetyo C , Pratomoatmojo N A , Kurniawati U F , Yusuf M 
Published: December 2021

Abstract
Economic growth encourages development growth in the Gerbangkertosusila (or can be shortened as GKS) region, which is a challenge for the agricultural sector. The phenomenon of changing the function of paddy fields to developed land because of the high demand for land can threaten the food security of a region. This research will model the trend of land use change and its impact on food security in GKS region in the next 20 years using cellular automata methods and quantitative statistics. Data collection was carried out by literature studies, field observations and interviews through questionnaires to relevant stakeholders. The results of the spatial modeling analysis of the paddy field conversion trend show that there are three regions that have the highest conversion rate of paddy fields in the GKS region, namely Sidoarjo, Gresik and Surabaya City. After further analysis related to food demand projections and rice production projections is carried out, Surabaya and Sidoarjo Regency is currently experiencing a food deficit which could last even in the years ahead. Having this result, the role of several other regencies such as Lamongan and Mojokerto Regency is needed in maintaining food security in the GKS region.
Determination of the location of dragon fruit agrotourism development in Bangorejo Sub-district, Banyuwangi based on agrotourism development factors and land carrying capacity
Authors: Umilia E , Nabila D H 
Published: December 2021

Abstract
Bangorejo Sub-district has abundant dragon fruit potential and can be developed into an agrotourism area. However, there are still problems including the drop in the price of dragon fruit when the main harvest arrives, the lack of added value of dragon fruit, and problems related to the land carrying capacity in which Bangorejo Sub-district contains expansive soil, namely land that is expanding and shrinking. This research was conducted to determine the location of dragon fruit agrotourism development in Bangorejo Sub-district, Banyuwangi based on the land carrying capacity. The methods used were the content analysis method for the first objective, namely identifying the factors that influence the development of dragon fruit agrotourism in Bangorejo Sub-district and scalogram analysis as well as the overlay for the second objective, namely identifying prospective agrotourism locations for agrotourism development in Bangorejo Sub-district based on agrotourism development factors and land carrying capacity. The results of this research found that the suitable villages for the dragon fruit agrotourism development includes Sukorejo, Ringintelu, Sambirejo, Sambimulyo, Temurejo, and Kebondalem Villages with the widest suitable land is at Kebondalem Village.
The government success in revitalizing Old City Semarang
Authors: Handaruni R , Marlina A , Winarto Y 
Published: December 2021

Abstract
The historic city will suffer damage eventually if left without any preservation action. One of the conservation measures is revitalization. Indonesia has several historic city heritages that have undergone revitalization and spread in big cities. Semarang Old City, Central Java is one of the historic areas that experienced significant changes after revitalization. The Semarang Old City revitalization has been able to revive an area that was once almost abandoned so that it is now a bustling area of visitors. Significant changes in Semarang Old City are an indication of successful revitalization. The problem found is how the government can successfully revitalize the old city of Semarang so that it becomes a tourist destination. This study aims to determine in the architecture theory what key strategies are carried out in the revitalization of the Old City of Semarang. This research uses the descriptive qualitative method with data obtained from observations. The result shows how the revitalization was carried out by the government, such as 1). Repairing old historic buildings to have economic value and attract visitors; 2). Arranging and repairing infrastructures, facilities, and utilities; 3). Add some facilities to support the tourism function.
The resilience of Jenang industrial traditional houses against development of the times
Authors: Putri V K , Pitana T S , Setyaningsih W 
Published: December 2021

Abstract
This research will reveal clarity about the sustainability of the traditional house of Kudus which is used as a house for the jenang industry. The Kudus traditional house or it can be called the joglo pencu house is a house that has a blend of acculturation with local Javanese Pesisiran characters. This character is the result of the cultural process of the Kudus community. The culture of making the traditional house of the Kudus as a residence has developed into a forum for household business activities or Home Based Enterprises (HBE), namely the Kudus jenang industry. The traditional house has been used for jenang industrial activities for generations. The Kudus traditional house is still used as a jenang production house, even though the development of buildings and technology is currently progressing. This paper discusses what factors make the jenang industry still maintain traditional houses for jenang production activities. The purpose of this study was to determine the factors that make traditional houses still function as jenang industrial production houses. This study uses a qualitative descriptive method of the Kudus traditional house. The results of this study will show that there is an effort to maintain the traditional house of the Kudus by developing socio-economic activities.
Heritage management: the value discontinuation of heritage sites in indonesia: problem and challenges
Authors: Tucunan K P , Perkasa M I 
Published: December 2021

Abstract
Indonesia was evolving in the term of cultural beliefs and value as well as their Identity. This process is well recorded by many archeological shreds of evidence from the pre-history, enlightenment era to the modern era. The problem of this shifting culture occurs when the archeological objects do not currently represent the identity of the society anymore. The objects that were valued are now experiencing value discontinuation. From sacred to profane, from hailed to abandoned, even some objects are being disregarded. This paper aimed to identify what value that has been discontinued from the tangible heritage sites in Indonesia. Observing three study cases: Shiva-Budha, Hindu, and also Islamic Heritage, this study concludes there is discontinuation in historic, aesthetic, social, and scientific values.
Building age profile and figure-ground image: defining the urban development pattern of Balikpapan City
Authors: Jordan N A , Sherlia  , Syafitri E D 
Published: December 2021

Abstract
As one of Indonesian city that emerged from the industrial sector, Balikpapan grew and was inhabited by transmigrates from various cultures. The development and growth patterns of the Balikpapan urban area was influenced by the culture of the residents, due to the absence of empire influence or colonialism. This research was conducted to identify the oldest area as a starting point of the urban development patterns of Balikpapan. The building-age profile method was used to identify the oldest building groups or blocks, which belong to the city’s heritage zone. In this analysis, a series of figure-ground images in several periods were collected to indicate the building age. Through the process of overlaying solid-void maps, the pattern of space-built interaction was generated as the patterns of urban development. Results shown that urban development, which was determined through overlay technique, was organic pattern, which was formed by several connected irregular shapes. The conservation of the urban pattern indicates the effort to achieve urban identity, as one of the sustainable urban form indicator.
On the relation between input and output distributions of scRNA-seq experiments
Authors: Schwabe Daniel , Falcke Martin 
Published: December 2021

Abstract

Motivation
Single-cell RNA sequencing determines RNA copy numbers per cell for a given gene. However, technical noise poses the question how observed distributions (output) are connected to their cellular distributions (input).

Results
We model a single-cell RNA sequencing setup consisting of PCR amplification and sequencing, and derive probability distribution functions for the output distribution given an input distribution. We provide copy number distributions arising from single transcripts during PCR amplification with exact expressions for mean and variance. We prove that the coefficient of variation of the output of sequencing is always larger than that of the input distribution. Experimental data reveals the variance and mean of the input distribution to obey characteristic relations, which we specifically determine for a HeLa dataset. We can calculate as many moments of the input distribution as are known of the output distribution (up to all). This, in principle, completely determines the input from the output distribution.

Availability and Implementation
Source code freely available at https://github.com/danielschw188/InputOutputSCRNASeq.

Supplementary information
Supplementary data are available at Bioinformatics online.
Governing Ecological Connectivity in Cross-Scale Dependent Systems
Authors: Keeley Annika T H , Fremier Alexander K , Goertler Pascale A L , Huber Patrick R , Sturrock Anna M , Bashevkin Samuel M , Barbaree Blake A , Grenier J Letitia , Dilts Thomas E , Gogol-Prokurat Melanie , Colombano Denise D , Bush Eva E , Laws Angela , Gallo John A , Kondolf Mathias , Stahl Amanda T 
Published: December 2021

AbstractEcosystem management and governance of cross-scale dependent systems require integrating knowledge about ecological connectivity in its multiple forms and scales. Although scientists, managers, and policymakers are increasingly recognizing the importance of connectivity, governmental organizations may not be currently equipped to manage ecosystems with strong cross-boundary dependencies. Managing the different aspects of connectivity requires building social connectivity to increase the flow of information, as well as the capacity to coordinate planning, funding, and actions among both formal and informal governance bodies. We use estuaries in particular the San Francisco Estuary, in California, in the United States, as examples of cross-scale dependent systems affected by many intertwined aspects of connectivity. We describe the different types of estuarine connectivity observed in both natural and human-affected states and discuss the human dimensions of restoring beneficial physical and ecological processes. Finally, we provide recommendations for policy, practice, and research on how to restore functional connectivity to estuaries.
Renin–angiotensin system blockers during the COVID-19 pandemic: an update for patients with hypertension and chronic kidney disease
Authors: Theodorakopoulou Marieta P , Alexandrou Maria-Eleni , Boutou Afroditi K , Ferro Charles J , Ortiz Alberto , Sarafidis Pantelis 
Published: December 2021

ABSTRACT
Hypertension and chronic kidney disease (CKD) are among the most common comorbidities associated with coronavirus disease 2019 (COVID-19) severity and mortality risk. Renin–angiotensin system (RAS) blockers are cornerstones in the treatment of both hypertension and proteinuric CKD. In the early months of the COVID-19 pandemic, a hypothesis emerged suggesting that the use of RAS blockers may increase susceptibility for COVID-19 infection and disease severity in these populations. This hypothesis was based on the fact that angiotensin-converting enzyme 2 (ACE2), a counter regulatory component of the RAS, acts as the receptor for severe acute respiratory syndrome coronavirus 2 cell entry. Extrapolations from preliminary animal studies led to speculation that upregulation of ACE2 by RAS blockers may increase the risk of COVID-19-related adverse outcomes. However, these hypotheses were not supported by emerging evidence from observational and randomized clinical trials in humans, suggesting no such association. Herein we describe the physiological role of ACE2 as part of the RAS, discuss its central role in COVID-19 infection and present original and updated evidence from human studies on the association between RAS blockade and COVID-19 infection or related outcomes, with a particular focus on hypertension and CKD.