bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical properties of porphyrin-based crystalline metal‒organic frameworks
Authors: Rajasree Sreehari Surendran , Li Xinlin , Deria Pravas 
Published: April 2021

AbstractMetal‒organic frameworks (MOFs) are widely studied molecular assemblies that have demonstrated promise for a range of potential applications. Given the unique and well-established photophysical and electrochemical properties of porphyrins, porphyrin-based MOFs are emerging as promising candidates for energy harvesting and conversion applications. Here we discuss the physical properties of porphyrin-based MOFs, highlighting the evolution of various optical and electronic features as a function of their modular framework structures and compositional variations.
Control of nuclear dynamics in the benzene cation by electronic wavepacket composition
Authors: Tran Thierry , Worth Graham A. , Robb Michael A. 
Published: April 2021

AbstractThe study of coupled electron-nuclear dynamics driven by coherent superpositions of electronic states is now possible in attosecond science experiments. The objective is to understand the electronic control of chemical reactivity. In this work we report coherent 8-state non-adiabatic electron-nuclear dynamics simulations of the benzene radical cation. The computations were inspired by the extreme ultraviolet (XUV) experimental results in which all 8 electronic states were prepared with significant population. Our objective was to study the nuclear dynamics using various bespoke coherent electronic state superpositions as initial conditions in the Quantum-Ehrenfest method. The original XUV measurements were supported by Multi-configuration time-dependent Hartree (MCTDH) simulations, which suggested a model of successive passage through conical intersections. The present computations support a complementary model where non-adiabatic events are seen far from a conical intersection and are controlled by electron dynamics involving non-adjacent adiabatic states. It proves to be possible to identify two superpositions that can be linked with two possible fragmentation paths.
Number of screws in the articular segment of distal humerus AO/OTA C-type fractures treated with open reduction internal fixation is associated with complication rate
Authors: Grogan Brian F. , Danford Nicholas C. , Lopez Cesar D. , Maier Stephen P. , Kongmalai Pinkawas , Kovacevic David , Levine William N. , Jobin Charles M. 
Published: April 2021

Introduction: Surgical treatment of distal humerus fractures can lead to numerous complications. Data suggest that the number of screws in the distal (articular) segment may be associated with complication rate. The purpose of this study is to evaluate the association between a number of screws in the distal segment and complication rate for surgical treatment of distal humerus fractures. We hypothesize that the number of screws in the articular segment of distal humerus AO/OTA C-type fractures treated with open reduction internal fixation (ORIF) will be inversely proportional to the complication rate. Methods: We performed a single-center retrospective cohort study of 27 patients who underwent ORIF of distal humerus fractures C-type with at least six months of radiographic and clinical follow-up. Clinical outcomes including a range of motion, pain, revision surgery for stiffness and/or heterotopic ossification (HO), nonunion, and persistent ulnar nerve symptoms requiring revision neurolysis were recorded. Results: In C-type fractures, the use of three or fewer articular screws was significantly associated with nonunion or loss of fixation (RR 17, p = 0.006). Nineteen of 36 (53%) patients experienced at least one complication. The surgical approach, plate configuration, age, and ulnar nerve treatment (none, in situ release, transposition) were not associated with the need for revision surgery. Men had a higher risk of requiring surgical contracture release due to improving post-operative stiffness (RR 12, p = 0.02). Conclusion: In this retrospective study, the use of three or fewer screws to fix articular fragments in AO type C fractures was a significant risk for nonunion or loss of fixation. Plate configuration and surgical approach did not correlate with outcomes. Men had higher rates of complications and required more frequent revision surgery compared to women.
Geriatrisches Assessment: Personalisierung des alten Tumorpatienten
Authors: Kolb Gerald F. , Leischker Andreas H. 
Published: April 2021

ZusammenfassungEin auf die Besonderheiten des älteren Patienten zugeschnittenes Geriatrisches Assessment kommt außerhalb von Studien kaum und schon gar nicht regelhaft in einer festen, etablierten Institution wie dem Tumorboard zum Einsatz. Diese Situation erscheint im Sinne der „personalisierten Medizin“ unbefriedigend. Das Geriatrische Assessment ist keine Konkurrenz zur bestehenden „personalized medicine“ mit molekularpathologisch unterstützter Entscheidung im Tumorboard – es soll eine sinnvolle Ergänzung sein, die sowohl den Tumor als auch den einzelnen Patienten hinsichtlich seiner alltagsrelevanten Defizite, aber auch Ressourcen umfassend beschreibt. Eine solche funktionsorientierte Betrachtung würde entscheidend helfen, dass weder eine teure und toxische Übertherapie, noch eine ineffektive und ressourcenbindende Untertherapie beim älteren Patienten erfolgt.
Leben nach Krebs: Gezielte Bewegungstherapie bei einer chronischen Fatigue
Authors: Siebert Stefanie , Baumann Freerk T. , Salchow Jannike 
Published: April 2021

ZusammenfassungEine der häufigsten Langzeitfolgen bei Krebsüberlebenden ist das Erschöpfungssyndrom, auch als „Cancer-Related Fatigue“ (CRF) bezeichnet. Eine Fatigue kann auch Jahre nach der Erkrankung noch bestehen bleiben und führt bei den Betroffenen zu erheblichen Einschränkungen des täglichen Lebens und der Lebensqualität. Bei der Behandlung einer chronischen Fatigue spielt die onkologische Bewegungstherapie eine entscheidende Rolle und konnte in mehreren Metaanalysen die stärkste Evidenz für eine erfolgreiche Symptombehandlung zeigen. Forschungsbedarf besteht jedoch weiterhin bezüglich einer optimalen Trainingssteuerung und Trainingsart, weshalb die multizentrische FatiGO-Studie konzipiert wurde, die die unmittelbare Wirksamkeit auf die Fatigue untersucht.
Die Misteltherapie beim Mammakarzinom und Fatigue
Authors: Paepke Daniela 
Published: April 2021

ZusammenfassungDie Mistel gehört in Deutschland zu den meistverordneten komplementärmedizinischen Krebsmedikamenten. Viele Patientinnen mit Mammakarzinom erhalten im Verlauf ihrer Erkrankung eine Misteltherapie. Präklinische Forschungen, klinische Studien und Übersichtsarbeiten liegen zum Einsatz der Misteltherapie beim Mammakarzinom vor. Hautsächlich findet die Mistel Anwendung bei Tumor-assoziierter Fatigue, zur Verbesserung der Lebensqualität und zur Verminderung systemtherapeutisch bedingter Nebenwirkungen.
Comparison and Association of Neck Extensor Muscles’
Endurance and Postural Function in Subjects with and without Chronic Neck Pain
– A Cross-Sectional Study
Authors: Kandakurti Praveen Kumar , Reddy Ravi Shankar , Kakarparthy Venkata Nagaraj , Rengaramanujam Kanagaraj , Tedla Jaya Shanker , Dixit Snehil , Gautam Ajay Prashad , Silvian Paul , Gular Kumar , Eapen Charu , CG Shashi Kumar 
Published: April 2021

Abstract
Purpose Neck extensor endurance (NEE) and position sense are vital for
maintaining cervical spine function and defects in these processes may be
associated with impaired postural control in chronic neck pain (CNP)
subjects. The study’s objectives are 1) to compare the cervical
extensor endurance capability and postural control of CNP subjects with
those of asymptomatic controls; 2) to investigate the association between
NEE and postural control.
Materials and Methods Sixty-four participants (38 asymptomatic, 38
with CNP) participated in this cross-sectional study. NEE was assessed using
a clinical extensor endurance test. Under open and closed eyes conditions,
postural control measures were tested with the Good Balance system. The
postural control parameters were AP-velocity (mm/s), ML-velocity
(mm/s) and Velocity moment (mm2). NEE capacity and postural control
parameters were compared and correlated between asymptomatic and CNP
subjects.
Results and Discussion CNP subjects showed lower NEE capacity
(p<0.001) and significantly larger AP-velocity (p<0.001),
ML-velocity (p<0.001) and Velocity moment (p<0.001) than
asymptomatic participants. NEE negatively correlated with AP-velocity
(r=−0.51, p=0.001), ML-velocity (r=0.46,
p=0.003) and velocity moment (r=0.38, p=0.020) in
asymptomatic subjects in eyes open condition and no correlations in subjects
with CNP. CNP subjects showed increased postural sway velocities and lowered
extensor endurance capacity compared to asymptomatic participants. No
correlations existed between NEE and postural control parameters in CNP
subjects.
Allenes: Versatile Building Blocks in Cobalt-Catalyzed C–H Activation
Authors: Volla Chandra M. R. , Shukla Rahul K. , Nair Akshay M. 
Published: April 2021

AbstractThe unique reactivity of allenes has led to their emergence as valuable coupling partners in transition-metal-mediated C–H activation reactions. On the other hand, due to its high abundance and high Lewis acidity, cobalt is garnering widespread interest as a useful catalyst for C–H activation. Here, we summarize cobalt-catalyzed C–H activations involving allenes as coupling partners and then describe our studies on Co(III)-catalyzed C-8 dienylation of quinoline N-oxides with allenes bearing a leaving group at the α-position for realizing a dienylation protocol.
Copper-Catalyzed Synthesis of β- and δ-Carbolines by Double N-Arylation of Primary Amines
Authors: Hung Tran Quang , Dang Tuan Thanh , Langer Peter , Van Phuc Ban , Do Ha Nam , Quan Nguyen Minh , Tuan Nguyen Ngoc , An Nguyen Quang , Van Tuyen Nguyen , Anh Hoang Le Tuan 
Published: April 2021

AbstractTwo efficient and practical approaches are reported for the synthesis of β- and δ-carbolines from 3,4-dibromopyridine. The synthesis is based on site-selective Cu-catalyzed double C–N coupling reactions and subsequent annulations by twofold Pd-catalyzed C–N coupling with amines.
The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease
Authors: Ferrazoli Natalia , Donadon Caroline , Rezende Adriano , Skarzynski Piotr H. , Sanfins Milaine Dominici 
Published: April 2021

Abstract
Introduction Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination.
Objective To review the literature on the application and findings of P300 as an indicator of PD.
Data Analysis The samples ranged from 7 to 166 individuals. Young adult and elderly male patients composed most study samples. The Mini-Mental State Examination test, the Unified Parkinson Disease Rating Scale, and the Hoehn and Yahr Scale were used to assess neurological and cognitive function. In terms of testing hearing function, few studies have focused on parameters other than the P300. The factors we focused on were how the P300 was modified by cognitive effects, its correlation with different PD scales, the effect of performing dual tasks, the effect of fatigue, and the influence of drug treatments.
Conclusion The use of the P300 appears to be an effective assessment tool in patients with PD. This event-related potential seems to correlate well with other neurocognitive tests that measure key features of the disease.
Effect of Heparanase and Heparan Sulfate Chains in Hemostasis
Authors: Nadir Yona 
Published: April 2021

AbstractHeparanase, the only mammalian enzyme known to degrade heparan sulfate chains, affects the hemostatic system through several mechanisms. Along with the degrading effect, heparanase engenders release of syndecan-1 from the cell surface and directly enhances the activity of the blood coagulation initiator, tissue factor, in the coagulation system. Upregulation of tissue factor and release of tissue factor pathway inhibitor from the cell surface contribute to the prothrombotic effect. Tissue factor pathway inhibitor and the strongest physiological anticoagulant antithrombin are attached to the endothelial cell surface by heparan sulfate. Hence, degradation of heparan sulfate induces further release of these two natural anticoagulants from endothelial cells. Elevated heparanase procoagulant activity and heparan sulfate chain levels in plasma, demonstrated in cancer, pregnancy, oral contraceptive use, and aging, could suggest a potential mechanism for increased risk of thrombosis in these clinical settings. In contrast to the blood circulation, accumulation of heparan sulfate chains in transudate and exudate pleural effusions induces a local anticoagulant milieu. The anticoagulant effect of heparan sulfate chains in other closed spaces such as peritoneal or subdural cavities should be further investigated.
Evaluation of Serum Immunoglobulins (IgG, IgA, IgM) and Circulating Immune Complexes in Oral Precancer and Cancer Patients
Authors: Madki Pooja , Tejasvi Mandya Lakshman Avinash , Paramkusam Geetha , Khan Ruheena , J. Shilpa 
Published: April 2021

Abstract
Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG, and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and precancer patients.
Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins, and CIC was estimated by turbidometry and ELISA method.
Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ±  118.02) mg/dL, oral cancers were 270.67 ( ±  171.44) mg/dL, and controls were 133.73 ( ±  101.31) mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ±  316) mg/dL, oral cancers were 1,234.27 ( ±  365.42) mg/dL, and controls were 593.87 ( ±  323.06) mg/dL.
Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer and cancer group, and Serum IgM levels were increased only in precancer. Also, significant increase in serum CIC levels were seen in oral precancer and cancer group on comparison with control.
The Influence of Topically Administered Heparin on Peripheral Microcirculation of the Skin: A Double-Blind, Randomized, Controlled Preliminary Study on 50 Healthy Subjects
Authors: Denzinger Markus , Held Manuel , Amr Amro , Krauß Sabrina , Bender Dominik , Daigeler Adrien , Wenger Andrea 
Published: April 2021

Abstract
Background Venous thrombosis is the most common cause of flap failure in the first days after surgery. Although heparin is one of the most important antithrombotic substances and is implemented in the therapy of various diseases, there are only a few studies addressing its topical administration in the field of flap surgery. Especially, very little is known about the effects of topical heparin and its impact on microcirculation. In this study we evaluated to what extent topically administered heparin influences skin microcirculation (capillary venous oxygen saturation SO2, blood filling of microvessels, blood flow, and velocity) in healthy subjects.
Methods Skin perfusion parameters on the forearm were measured with the O2C device in a double-blinded, controlled, and randomized study with 50 healthy subjects after administration of heparin ointment in three different concentrations and a control ointment (dexpanthenol).
Results Topically administrated heparin slightly increased SO2 (max. 187 ± 285 SD or standard deviation % vs. 145 ± 129 SD %), flow (max. 264 ± 427 SD % vs. 151.74 ± 111 SD %), and velocity (max. 153 ± 149 SD % vs. 122 ± 56 SD %) after an incubation time of 60 minutes in comparison to control. No statistically significant difference could be detected regarding heparin concentration.
Conclusion As a first important step in possible future implementing of heparin as a topical administration in flap surgery, our data—although not statistically significant—indicate that heparin can improve microcirculation (SO2, flow) in healthy subjects. Nevertheless, further research in subjects with impaired microcirculation is necessary.
Progressive Leukodystrophy-Like Demyelinating Syndromes with MOG-Antibodies in Children: A Rare Under-Recognized Phenotype
Authors: Yazbeck Elise , Maurey Hélène , Leroy Carole , Horellou Philippe , Napuri Silvia , Lali Mohammed , Adam Clovis , Husson Beatrice , Sevin Caroline , Deiva Kumaran 
Published: April 2021

AbstractAcquired demyelinating syndromes (ADS) are frequently associated with myelin oligodendrocytes glycoprotein (MOG) antibodies in children. Clinical phenotypes are heterogeneous and may delay the diagnosis, especially when they relapse and are atypical, mimicking diseases such as multiple sclerosis or neuromyelitis optica spectrum disorders . Here, we describe two children: one with a progressive cognitive and behavioral deterioration with seizures after only one relapse and the other with similar clinical impairments associated with multiple relapses. Brain magnetic resonance imaging revealed a subsequent progressive leukodystrophy-like lesion with diffuse bilateral white matter injuries in both patients. Cerebrospinal fluid analysis showed pleiocytosis, increased level of proteins with no oligoclonal bands. Metabolic and inflammatory blood markers were all negative. Brain biopsy was performed in the second child and nonspecific inflammatory lesions with no argument for histiocytosis or tumor were observed. Clinical and radiological stabilization were obtained after active immunotherapy. Retrospective analysis of anti-MOG antibodies in these two children was positive at the earlier stage of the disease and turned negative after treatment and during follow-up. Leukodystrophy-like ADS with anti-MOG-antibodies may display distinct progressive phenotype and have a severe neurological prognosis. Early diagnosis and appropriate treatment may improve outcome in these children.
What Industry Wants: An Empirical Analysis of Health Informatics Job Postings
Authors: McLane Tara M. , Hoyt Robert , Hodge Chad , Weinfurter Elizabeth , Reardon Erin E. , Monsen Karen A. 
Published: April 2021

Abstract
Objectives To describe the education, experience, skills, and knowledge required for health informatics jobs in the United States.
Methods Health informatics job postings (n = 206) from Indeed.com on April 14, 2020 were analyzed in an empirical analysis, with the abstraction of attributes relating to requirements for average years and types of experience, minimum and desired education, licensure, certification, and informatics skills.
Results A large percentage (76.2%) of posts were for clinical informaticians, with 62.1% of posts requiring a minimum of a bachelor's education. Registered nurse (RN) licensure was required for 40.8% of posts, and only 7.3% required formal education in health informatics. The average experience overall was 1.6 years (standard deviation = 2.2), with bachelor's and master's education levels increasing mean experience to 3.5 and 5.8 years, respectively. Electronic health record support, training, and other clinical systems were the most sought-after skills.
Conclusion This cross-sectional study revealed the importance of a clinical background as an entree into health informatics positions, with RN licensure and clinical experience as common requirements. The finding that informatics-specific graduate education was rarely required may indicate that there is a lack of alignment between academia and industry, with practical experience preferred over specific curricular components. Clarity and shared understanding of terms across academia and industry are needed for defining and advancing the preparation for and practice of health informatics.
Total Infrapatellar Fat Pad Excision Leads to Worse Isokinetic Performance in Total Knee Arthroplasty: A Randomized Controlled Trial
Authors: Cankaya Deniz , Akti Sefa , Yasar Niyazi Erdem , Karakus Dilek , Unal Kazim Onur , Karhan Taha Esref , Sezgin Erdem Aras 
Published: April 2021

AbstractThere are concerns that total infrapatellar fat pad (IPFP) excision in total knee arthroplasty (TKA) results in patellar tendon shortening due to ischemic contracture, but individual preference of the surgeon is still the main determinant between total or partial excision. The aim of this randomized controlled study was to compare isokinetic performance and clinical outcome of TKAs with total and partial excision of the IPFP. Seventy-two patients scheduled to undergo TKA for primary knee osteoarthritis by a single surgeon were randomly assigned to either total or partial excision group. Patients were evaluated preoperatively and at postoperative 1 year, with Knee Society Score (KSS) and isokinetic measurements. The physiatrist performing isokinetic tests and patients were blinded to the study. There were no significant differences between the groups in respect of age, body mass index, gender, and preoperative KSS and isokinetic performance. Postoperatively, both groups had improved KSS knee and KSS function scores, with no difference determined. Knee extension peak torque was significantly higher postoperatively in the partial excision group at postoperative 1 year (p = 0.036). However, there were no significant differences in knee flexion peak torque following TKA (p = 0.649). The results of this study demonstrated that total excision of the IPFP during TKA is associated with worse isokinetic performance, which is most likely due to changes in the knee biomechanics with the development of patella baja. Partial excision of the IPFP appears to be a valid alternative to overcome this potential detrimental effect without impeding exposure to the lateral compartment. This is a Level I, therapeutic study.
Versatile four-leg thermoelectric module test setup adapted to a commercial sample holder system for high temperatures and controlled atmospheres
Authors: Schuler Raphael , Madathil Reshma K. , Norby Truls 
Published: April 2021

A high temperature thermoelectric test setup for the NORECS ProboStat™ sample holder cell has been designed, constructed, and tested. It holds four thermoelectric legs of up to 5 × 5 mm2 area each and flexible height, allows various interconnects to be tested, and utilizes the spring-load system of the ProboStat for fixation and contact. A custom stainless steel support tube flushed with water provides the cold sink, enabling large temperature gradients. Thermocouples and electrodes as well as the gas supply and outer tube use standard ProboStat base unit feedthroughs and dimensions. The setup allows for testing in controlled atmospheres with the hot side temperature of up to around 1000 °C and a temperature gradient of up to 600 °C. We demonstrate the test setup on a four-leg Li–NiO/Al–ZnO module with gold interconnects. The comparison between the predicted performance based on individual material parameters and the experimentally obtained module performance underlines the necessity for testing materials in combination, including interconnects. The four-leg setup allows versatile match-screening, performance evaluation, and long-term stability studies of thermoelectric materials in combination with hot and cold side interconnects under realistic operational conditions.