bluuebunny/crossref_metadata_2025_split huggingface dataset:
N6-Methylandenosine-Related lncRNAs in Tumor Microenvironment Are Potential Prognostic Biomarkers in Colon Cancer
Authors: Zhang Hongliang , Zhao Lei , Li Songyan , Wang Jing , Feng Cong , Li Tanshi , Du Xiaohui 
Published: June 2021

BackgroundLncRNA dysregulation and the tumor microenvironment (TME) have been shown to play a vital role in the progression and prognosis of colon cancer (CC). We aim to reveal the potential molecular mechanism from the perspective of lncRNA in the TME and provide the candidate biomarkers for CC prognosis.MethodsESTIMATE analysis was used to divide the CC patients into high and low immune or stromal score groups. The expression array of lncRNA was re-annotated by Seqmap. Microenvironment-associated lncRNAs were filtered through differential analysis. The m6A-associated lncRNAs were screened by Pearson correlation analysis. Lasso Cox regression analyses were performed to construct the m6A- and tumor microenvironment-related lncRNA prognostic model (m6A-TME-LM). Survival analysis was used to assess the prognostic efficacy of candidate lncRNAs. Enrichment analyses annotated the candidate genes’ functions.ResultsWe obtained 25 common differentially expressed lncRNAs (DELs) associated with immune microenvironment and m6A-related genes for subsequent lasso analysis. Four out of these DELs were selected for the m6A-TME-LM. All the four lncRNAs were related to overall survival, and a test set testified the result. Further stratification analysis of the m6A-TME-LM retained its ability to predict OS for male and chemotherapy adjuvant patients and performed an excellent prognostic efficacy in the TNM stage III and IV subgroups. Network analysis also found the four lncRNAs mediated co-expression network was associated with tumor development.ConclusionWe constructed the m6A-TME-LM, which could provide a better prognostic prediction of CC.
A Regression Model to Predict Augmented Renal Clearance in Critically Ill Obstetric Patients and Effects on Vancomycin Treatment
Authors: Tang Lian , Ding Xin-yuan , Duan Lu-fen , Li Lan , Lu Hao-di , Zhou Feng , Shi Lu , Lu Jian , Shen Yi , Zhuang Zhi-wei , Sun Jian-tong , Zhou Qin , Zhu Chen-qi , Li Jing-jing , Yu Yan-xia 
Published: June 2021

Background: Augmented renal clearance (ARC) risk factors and effects on vancomycin (VCM) of obstetric patients were possibly different from other populations based on pathophysiological characteristics. Our study was to establish a regression model for prediction of ARC and analyze the effects of ARC on VCM treatment in critically ill obstetric patients.Methods: We retrospectively included 427 patients, grouped into ARC and non-ARC patients. Logistic regression analysis was used to analyze the factors related to ARC. Receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of the model for ARC. Patients who received VCM therapy were collected. The published VCM population pharmacokinetic (PPK) model was used to calculate pharmacokinetic parameters. A linear regression analysis was made between the predicted and measured concentrations.Results: Of the 427 patients, ARC was present in 201 patients (47.1%). The independent risk factors of ARC were heavier, greater gestational age, higher albumin level, fewer caesarean section, severe preeclampsia and vasoactive drug; more infection, hypertriglyceridemia and acute pancreatitis. We established the above nine-variable prediction regression model and calculated the predicted probability. ROC curve showed that the predicted probability of combined weight, albumin and gestational age had better sensitivity (70.0%) and specificity (89.8%) as well as the maximal area under the curve (AUC, AUC = 0.863). 41 cases received VCM; 21 cases (51.2%) had ARC. The initial trough concentration in ARC patients was lower than in non-ARC patients (7.9 ± 3.2 mg/L vs 9.5 ± 3.3 mg/L; p = 0.033). Comparing the predicted trough concentration of two published VCM PPK models with the measured trough concentration, correlation coefficients (r) were all more than 0.8 in the ARC group and non-ARC group. AUC was significantly decreased in the ARC group (p = 0.003; p = 0.013), and clearance (CL) increased in the ARC group (p &lt; 0.001; p = 0.008) when compared with the non-ARC group.Conclusion: ARC is a common state in critically ill obstetric patients. The regression model of nine variables had high predictive value for predicting ARC. The published VCM PPK models had good predictive performance for predicting trough concentrations of obstetric patients. Pharmacokinetic parameters of VCM are different in ARC obstetric patients, which results in enhanced VCM clearance and decreased trough concentration.
It's Not That Great Anymore: The Central Role of Defense Mechanisms in Grandiose and Vulnerable Narcissism
Authors: Kampe Leonie , Bohn Johannes , Remmers Carina , Hörz-Sagstetter Susanne 
Published: June 2021

Objectives: The concept of narcissism contains a yet unresolved paradox: Its grandiose facet depicts the psychopathological core but is often associated with life-satisfaction and overall functioning, whereas its vulnerable facet is associated with psychological distress, but still not included in the international classification systems. Our goal was to investigate the relationship between the two facets of narcissism expecting underlying defense mechanisms to be core elements. First, we aimed to identify defense mechanisms specific to grandiose and vulnerable narcissism. Second, we explored how both facets are differentially associated with psychological distress, assuming that grandiose narcissism would be associated with less psychological distress than vulnerable narcissism. Third, we investigated the mediating role of defense mechanisms between narcissism and psychological distress.Methods: In a non-clinical sample of N = 254 individuals, the Pathological Narcissism Inventory was used for the assessment of grandiose and vulnerable facets of narcissism, the Defense Style Questionnaire for defense mechanisms, and the Brief Symptom Inventory for psychological distress. Structural equation modeling was employed to identify distinct factors of grandiose and vulnerable narcissism. Associations between specific defense mechanisms and both facets were calculated. Furthermore, the direct association between both facets and psychological distress was examined. We finally explored whether defense mechanisms mediate the association between distress and both grandiose and vulnerable narcissism.Results: A distinct pattern of defense mechanisms for each facet of narcissism could be extracted: Both facets showed significant positive correlations with specific intermediate and all maladaptive defense mechanisms. Only grandiose narcissism showed significant positive correlations with adaptive defenses. Vulnerable narcissism showed negative correlations with all adaptive defenses. Specifically, grandiose narcissism was significantly related to anticipation, pseudo-altruism, rationalization, and dissociation, whereas vulnerable narcissism was negatively related to all these defense mechanisms. While grandiose narcissism was not related to psychological distress, vulnerable narcissism showed high correlations with psychological distress. Intriguingly, mediator analysis found that grandiose narcissism was related to psychological distress when mediated by maladaptive defense mechanisms.Discussion: The role of defense mechanisms is central for a differentiated understanding of the two different faces of narcissism. The relevance of assessing defense mechanisms in clinical settings, and related empirical findings are discussed.
Implementasi Industri 4.0 dan Aplikasi Lamikro Untuk Entitas Mikro, Kecil, dan Menengah
Authors: Ahmar Nurmala , Ekaningtyas Diah , Shonhadji Nanang 
Published: June 2021

Abstrak
Revolusi industri bukan hanya dari sisi teknologi mesin tetapi juga berkembang ke teknologi informasi, seperti internet dan aplikasi. Usaha mikro berkembang pesat seiring perkembangan teknologi. Kementerian Koperasi dan Usaha Kecil Menengah (Kemenkop UKM) melansir sebanyak 3,79 juta usaha mikro, kecil, dan menengah (EMKM) sudah memanfaatkan platform online dalam memasarkan produknya. Jumlah ini berkisar 8 persen dari total pelaku EMKM yang ada di Indonesia, yakni 59,2 juta. Mendukung perkembangan tersbut Ikatan Akuntan Indonesia menerbitkan Standar Akuntansi Entitas Menengah Kecil tahun 2016 dan efektif berlaku Januari 2018. Kemenkop UKM menindaklanjuti pemberlakuan standar tersebut dengan menerbitkan aplikasi penyusunan laporan keuangan mikro dengan nama Lamikro (Laporan Keuangan Mikro) pada Oktober 2017. Sampai dengan September 2018 Lamikro telah diunduh lebih dari 5000 pengunduh. Kemudahan, kesederhaan dan fleksibilitas aplikasi tersebut menarik pelaku usaha untuk memanfaatkannya. Implementasi Lamikro pada capaian angka tersebut belum dikatakan berhasil jika dibandingkan dengan 3,79 juta pelaku usaha yang menggunakan platform online apalagi jika dbandingkan dengan 59 juta pelaku usaha mikro di Indonesia. Artikel esai ini bertujuan untuk menggali potensi penggunakan Lamikro dan menawarkan alternatif-alternatif solusi agar implementasi Lamikro berjalan dengan efektif.
Abstract
The industrial revolution was not only in terms of machine technology but also developed into information technology, such as the internet and applications. Micro businesses are growing rapidly along with technological developments. Kementerian Koperasi dan Usaha Kecil Menengah (Kemenkop UKM) launched a total of 3.79 million micro, small and medium enterprises (MSMEs) that have used online platforms to market their products. This number is around 8 percent of the total MSME players in Indonesia, which is 59.2 million. Supporting the development of the Indonesian Institute of Accountants issued the Accounting Standards for Small Medium Enterprises in 2016 and effective January 2018. The UKM Ministry of Cooperatives followed up on the implementation of the standard by issuing applications for the preparation of microfinance reports under the Lamikro (Microfinance Report) in October 2017. September 2018 Lamikro has been downloaded more than 5000 downloaders. Convenience, simplicity and flexibility of the application attracts business people to use it. Lamikro's implementation on the achievement of these figures has not been said to be successful when compared to the 3.79 million business people who use online platforms especially if compared to 59 million micro-entrepreneurs in Indonesia. This essay aims to explore the potential of using Lamikro and offer alternative solutions so that the implementation of Lamikro effectively.
Prospective Study on Group of Heart Failure Patients in Ibn Al-Bitar Center for Cardiac Surgery for Evaluation of CRT-D Effect
Authors: Al-Saffar Mais O. , Al-Taweel Rafid B. , Al-Dahhan Zaid , Sarhan Khalil 
Published: June 2021

Objectives: The main objective of this study was to assess the effect of CRT-D device on the cardiacmechanics for group of patients with end-stage heart failure (HF).Methods: For 13 patients with heart disease who are supposed to undergo a CRT (Cardiac ResynchronizationTherapy) implant, a single center study has been performed at the Ibn Al-Bitar center for cardiac surgery.End stage HF (heart failure) with (NYHA class III or IV) left ventricular ejection fraction < 35% and QRSinterval >120 ms were selected for CRT. Before CRT implantation, the clinical evaluation was measured and2-D echocardiography was performed to measure left ventricular volume and ejection fraction. Combiningboth M-mode echocardiography, TDI color-coded tissue and speckle tracking technique, left ventriculardesynchrony has been tested. Clinical condition and increase in echocardiographic parameters (leftventricular ejection fraction and volume) were re-assessed after 3 months of follow-up.Results: Post CRT-D implantation, significant clinical improvement was observed in 54% of the patients.Class of functional capacity decreased in the third month after implantation compared to basal levels (P <0.01). Left ventricular end-diastolic (LVIDd) and end-systolic diameters (LVIDs) decreased, and LV systolicfunction improved significantly at the 3rd month after implantation when compared to baseline values.Decrease in LV volumes continued to the 3rd month, that the decrease in LVESV was statistically significant(P = 0.07), reduction in end-diastolic volume was also statistically significant (P = 0.07). Ejection fractionand fractional shortening showed insignificant (p > 0.05) increase after CRT-D implantation.Discussion: Patients were divided into responders and non-responders, based on improvement in NYHAfunctional class, it became evident that an improvement in clinical parameters was observed only in theresponders. Moreover, improvements in LVEF and reverse remodeling were also observed only in theresponders.
Conclusion: Cardiac resynchronization therapy is considered as a therapy for patients with severe heartfailure, with statistically significantly improve in clinical and echocardiographic parameters.
Procedure for the quantification of the degradation index of Photovoltaic Generators
Authors: Roger Proenza Y. , Emilio Camejo C. José , Rubén Ramos H. 
Published: June 2021

A procedure is presented for the quantification of the degradation index of Photovoltaic Generators, based on the quantification of the operational losses inherent in the system, which allows maintaining the nominal operating conditions and by the warranty terms of the photovoltaic generator. A photovoltaic generator connected to the network with a nominal power of 7.5 kWp, installed in the Solar Energy Research Center of Santiago de Cuba, is used to evaluate and validate the procedure. The starting point is the mathematical model of the photovoltaic generator, then the operational losses of the photovoltaic generator are quantified and the mathematical model is adjusted to real conditions, through a polynomial adjustment. The results obtained show that the photovoltaic generator presents deviations in terms of the nominal power generation, because the operational losses are 7% with respect to the values ​​given by the manufacturer.
Some Aspects of the Tachyon Inflation with Superpotential in Confrontation with Planck2018 Data
Authors: Rashidi Narges 
Published: June 2021

Abstract
We study tachyon inflation in the presence of the superpotential as an inflationary potential. We study the primordial perturbations and their non-Gaussian feature in the equilateral configuration. We use the Planck2018 TT, TE, EE+lowE+lensing+BK14+BAO joint data at 68% CL and 95% CL to perform numerical analysis on the scalar perturbations and seek the observational viability of the tachyon inflation with superpotential. We also check the observational viability of the model by studying the tensor part of the perturbations and comparing the results with Planck2018 TT, TE, EE+lowE+lensing+BK14+BAO+ LIGO&Virgo2016 joint data at 68% CL and 95% CL. By studying the phase space of the model’s parameters, we predict the amplitude of the equilateral non-Gaussianity in this model. The reheating phase after inflation is another issue that is explored in this paper. We show that, in some ranges of the model’s parameters, it is possible to have an observationally viable tachyon model with superpotential.
Étudier l’imaginaire du stage en Institut Médico-Éducatif : un outil pour mieux situer le rapport à l’abstraction des jeunes accueillis
Authors: Agraz Antoine 
Published: June 2021

L’objet de cet article est de décrypter l’imaginaire des jeunes accueillis en IME (Institut Médico-Éducatif) du point de vue de leurs représentations de la formation en stage. Nous nous inscrivons ici dans un double ancrage théorique (Gaston Bachelard et Gilbert Durand) pour analyser la dimension symbolique de la formation en stage à l’IME, à l’aune de l’intérêt porté à cette dernière par les jeunes accueillis. Comment la formation en stage est-elle investie symboliquement par les jeunes de l’IME ? Quelles en sont les images dominantes ? L’imaginaire des jeunes de l’IME détermine leur représentation du stage, donc leur façon de s’y conduire. Nous verrons également que l’histoire des idées dans le champ du handicap intellectuel et de la pédagogie donne du sens à l’étude des nuances et des dimensions cachées liées à l’imaginaire du stage. Nous concluons en montrant comment nos résultats convoquent la question complexe et fondatrice de l’accès à l’abstraction dans le cadre du stage pour le public accueilli en IME.
L’enseignant et le jeu : de l’expérience de joueur à l’enseignement du jeu ?
Authors: Desvages-Vasselin Vanessa , Buznic-Bourgeacq Pablo 
Published: June 2021

Nous nous interrogeons sur la place du jeu et de son authenticité sur le temps d’enseignement et plus spécifiquement sur les raisons de l’enseignant à faire ou non jouer. Cet article s’appuie sur une recherche visant à identifier les usages du jeu par les enseignants à l’école élémentaire. Nous nous sommes interrogés sur la légitimité du jeu à l’école dans un premier temps pour identifier ensuite les tensions inhérentes au « jouer » dans le cadre scolaire. Nous centrons notre analyse sur le sujet enseignant, celui-ci apparaissant comme le dernier ressort de ces tensions, et sur sa position subjective adoptée en classe quant aux pratiques ludiques. Pour cela nous analysons les pratiques de trois professeurs des écoles, confrontées à l’intégration de pratiques ludiques au cœur de leur enseignement.
Prévention des risques professionnels et formation : éléments de réflexion à partir de la didactique professionnelle et de l’ergonomie
Authors: Vidal-Gomel Christine 
Published: June 2021

Cet article propose d’appréhender la formation à la prévention des risques professionnels à partir d’apports croisés de l’ergonomie et de la didactique professionnelle. Une étude de cas dans le domaine de la livraison du béton prêt-à-l’emploi sur des chantiers est présentée. Elle montre les redéfinitions d’une règle de sécurité au sein des entreprises, qui la rendent peu opérationnelle pour les opérateurs, et les ressources que les opérateurs ont constituées avec l’expérience. Ces ressources se révèlent aussi limitées. En effet tout ne peut pas être acquis par l’expérience en situation et la médiation par les pairs. Il s‘agit alors d’identifier des « savoirs professionnels de référence » pour concevoir des contenus de formation qui articulent « sécurité réglée » et « gérée », nécessaires pour produire la sécurité. Cette démarche de conception de formation basée sur l’analyse de l’activité en ergonomie et en didactique professionnelle permet ainsi de rompre avec une approche technico-réglementaire et béhavioriste qui domine encore dans le monde de la formation à la prévention des risques professionnels.
Biotensegrity Is Needed in Athletic Training Professional Education
Authors: Tomchuk David , Anderson Barton E. 
Published: June 2021

Context
Tensegrity is a structural-organization model initially described in the architecture and design fields. By applying tensegrity design principles to biological structures, scientists have developed biotensegrity to explain a complex systems-on-systems structural-organization philosophy for integrated human movements.

Objective
To provide a brief historical overview of tensegrity and biotensegrity principles, including recommendations and benefits for integrating these structural models into athletic training education.

Background
Tensegrity and biotensegrity structures require constant interaction between continuous tension and discontinuous compression elements that connect through focal adhesion points. During the 1970s and 1980s, scientists applied tensegrity concepts to biological organisms to create an integrated model of human structure and interaction. Since then, biotensegrity has grown as an accepted biological structural model capable of explaining complex and integrated human movements.

Synthesis
By teaching tensegrity and biotensegrity principles, athletic training educators can provide athletic training students with a basic and consistent human body structural model. With this knowledge, students can better comprehend the integrated kinetic chain, including current and future prevention, examination, and rehabilitation paradigms.

Results
Although absent from the Practice Analysis, seventh edition, and the 2020 Commission on Accreditation of Athletic Training Education curricular content standards, tensegrity and biotensegrity relate to many injury prevention, examination, treatment, and rehabilitation concepts regularly taught in professional athletic training programs.

Recommendation(s)
Athletic training educators should consider ways to incorporate biotensegrity models into professional athletic training programs to improve critical thinking and whole-person health care principles of athletic training students.

Conclusion(s)
Integrating tensegrity and biotensegrity principles into professional athletic training programs provides a structural hierarchy of human body organization that athletic training students can apply to a multitude of current and future methodical approaches.
Functional outcome of type 13 C2 distal humerus fractures treated with precontoured locking plates
Authors: Gowtam S. V. , Gunaki Ravindra B. 
Published: June 2021

Background:
Distal humerus fractures pose the most challenging task in treatment, which can lead to poor functional outcomes. Anatomic reduction and internal fixation, along with early mobilization, are predicted to improve the functional outcomes. To evaluate the functional outcome, rate of malunion, and intercondylar fixation of distal humerus fractures treated with anatomically precontoured locking plates.

Methods:
Thirty patients of either sex admitted with type 13 C2 distal humerus fractures, were included in this prospective study. All patients underwent open reduction and internal fixation with anatomically precontoured locking plates and screws using the modified triceps tongue flap approach. Postoperatively, patients were followed up for 6 months. During follow-up, they were evaluated clinically, radiologically, and functionally by mayo elbow performance score (MEPS). The results were analyzed using Chi-square test.

Results:
A majority of the injuries were seen in males (66.7% vs. 33.3%). The mean age was 36.9 ± 14.7 years. The common mode of injury was through road traffic accident (66.7%). The right upper limb (76.7%) was the most common side involved. The overall excellent/good scores, according to the MEPS, were observed in 80% of the patients. The average time taken for the radiological union at the fracture site was 10.2 ± 2.1 weeks. The mean arc of extension-flexion at 6th weeks was 32.1°–104.1° and at 6th months was 11.5°–124.2°. The complications were early superficial infection (3.3%), ulnar neuropraxia (3.3%), delayed union (3.3%), malunion (3.3%), and chronic osteomyelitis (3.3%).

Conclusion:
Distal humerus fractures treated with anatomically precontoured locking plates was effective in preserving the functional outcome of the elbow.