bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic response to burn injury: a comprehensive bibliometric study
Authors: Li Yixu , Liu Yifan , Xie Sujie , Zhu Yushu , Ding Xinran , Zhang Wei , Xian Shuyuan , Wu Guosheng , Sun Hanlin , Yan Jiale , Lu Bingnan , Yao Yuntao , Qian Weijin , Lu Yuwei , Yang Yiting , Xu Dayuan , Huang Runzhi , Ji Shizhao 
Published: January 2025

ObjectiveBurns lead to systemic changes manifested by systemic disturbances in water-electrolyte balance and systemic metabolic and inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, and inflammatory dysregulation mechanisms. This study aimed to provide a comprehensive bibliometric analysis of the burn metabolism research field, identifying key trends, influential contributors, and emerging research hotspots to inform future investigative efforts. Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.MethodsWe obtained 8,823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. In this work, biblioshiny was used to visualize and analyze the data, and VOSviewer was used to verify the results.ResultsFrom a total of 8,823 publications, we found a general upward trend in annual publications and citation frequency. According to Bradford’s Law, 21 high-production journals were classified as core sources based on the number of publications, and the most productive journal was Burns. The most published countries and authors in this field were the United States and Herndon DN. The most local cited document in this field was the article titled “Catecholamines: Mediator of the Hypermetabolic Response to Thermal Injury” authored by Wilmore DW. The thematic map showed that studies on injury, thermal injury, and sepsis were relatively mature. In contrast, research on metabolism, stress, and responses, and research on mortality, resistance, and management were less well-developed but were essential for the field.ConclusionResearch on burns and metabolism is increasing. Based on the bibliometric analysis, our study summarized the complex interplay between burn-induced systemic metabolic alterations and inflammatory responses, emphasizing the significance of hypermetabolism and its management. The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research.
The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis
Authors: Ayres Denise Vianna Machado , Uchiyama Sabrina Saemy Tome , Prates Andréa Oliveira , Lopes Rosana Aparecida Freitas , Silva Antenor Bispo Santos , Tsukimoto Denise Rodrigues , Amorim Rosimeire Alves , Ribeiro Taynah Souza , Santos Artur Cesar Aquino , Sugawara André Tadeu , Montagnini Marcos , Battistella Linamara Rizzo , Imamura Marta 
Published: January 2025

BackgroundKnee osteoarthritis (KOA) is the most common form of arthritis in adults and a leading cause of years lived with disability, representing a significant burden on healthcare worldwide.ObjectiveDescribe the structure and educational elements of the Knee-SCHOOL, a brief patient-centered multidisciplinary educational program for patients with KOA.DesignObservational prospective study.SettingAcademically affiliated rehabilitation outpatient center in Brazil.MethodsThe program consisted of three in-person educational sessions (4.5 hr each) for 55 community dwelling adults, aged ≥50 years, with primary KOA-related pain. Study measures included demographic data (age, sex, and educational level), pain duration (years), pain intensity (visual analogue scale), affected knee (right, left, or both knees), comorbidities (presence of hypertension, diabetes, and hypercholesterolemia), Body Mass Index (BMI), Bristol Stool Scale, Adapted Healthy Eating Index (AHEI), bioelectrical impedance, daytime sleepiness, and the impact of the KOA on pain, symptoms, activities of daily living, recreation, and quality of life. Participants attended educational sessions delivered by a multidisciplinary team (two physicians, two nurses, two physical therapists, one occupational therapist, one dietitian, one psychologist, one social worker, and one physical educator) addressing several aspects of KOA. They also participated in supervised exercise practice and a home exercise program.ResultsFifty-five subjects completed the study. The mean age was 67.73 (± 7.73) years; most were females (70.9%), 92.7% had bilateral KOA, with mean pain duration of 12.41 (± 10.17) years. The mean BMI was 32.52 (± 5.99), 65.5% were obese, and 96.4% reported an inadequate diet. KOA had a more negative impact on sports, recreation and quality of life. Daytime sleepiness was uncommon. The mean pain intensity, measured with visual analogue scale, score reduced from 5.52 (± 2.11) at baseline to 4.04 (± 2.38) after the program (week 2). The effect size was 0.7 (95% CI 0.32 to 1.07). All participants received the program well, with no drop-out rates or reported adverse events.ConclusionThe Knee-SCHOOL utilized a multidisciplinary educational approach and an exercise practice addressing multiple aspects of KOA pain. While more studies are needed to assess the longitudinal impact of the program, it was promising in managing pain.
Diagnostic value of lung function tests in long COVID: analysis of positive bronchial provocation test outcomes
Authors: Liu Wei , Feng Qixuan , Yuan Xuefeng , Lu Chang , Wang Shuang , Yuan Yadong 
Published: January 2025

BackgroundLong COVID patients are prone to bronchial hyperresponsiveness and respiratory symptoms like coughing and breathing difficulties, often with positive bronchial provocation test (BPT) results.ObjectiveThis study aims to evaluate the diagnostic value of various lung function tests in patients with long-term COVID-19, explicitly focusing on positive BPT outcomes.MethodsOur study analyzed the BPT outcomes and various pulmonary function parameters of all 9,406 COVID-19 patients who met the inclusion criteria and visited our hospital between February 24, 2022, and April 28, 2024. Key indicators included forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), and single-breath diffusing capacity for carbon monoxide (DLCOc SB). A logistic regression model was employed to identify factors influencing positive BPT results, while the receiver operating characteristic (ROC) curve was used to assess the diagnostic efficacy of these indicators.ResultsA total of 4211 valid samples were analyzed, with 3388 patients (80.46%) testing positive for BPT. Significant differences were observed between positive and negative groups regarding age, gender, smoking status (all P &lt; 0.05), and specific lung function indicators, including FVC, FEV1/FVC ratio, maximum of vital capacity (VC max), and DLCOc SB (all P &lt; 0.001). Logistic regression identified age, MEF50, and DLCOc SB as independent factors influencing positive BPT results. The area under the ROC curve for all assessed factors was &lt;0.700, indicating limited diagnostic value.ConclusionAge, the small airway function indicator MEF50, and the pulmonary diffusion function indicator DLCOc SB are independent influencing factors for BPT positivity in long-term COVID patients. However, baseline data and lung function indicators have limited utility for diagnosing positive BPT in this population, highlighting the complex nature of post-COVID respiratory symptoms.
Application of cold atmospheric plasma for decontamination of toxigenic fungi and mycotoxins: a systematic review
Authors: Oliveira Amanda Cristina Dias de , Ali Sher , Corassin Carlos Humberto , Ullah Sana , Pereira Karina Nascimento , Walsh James Leon , Hojnik Nataša , Oliveira Carlos Augusto Fernandes de 
Published: January 2025

IntroductionMicrobial contamination remains a vital challenge across the food production chain, particularly due to mycotoxins—secondary metabolites produced by several genera of fungi such as Aspergillus, Fusarium, Alternaria, and Penicillium. These toxins, including aflatoxins, fumonisins, ochratoxins, and trichothecenes (nivalenol, deoxynivalenol, T2, HT-2). These contaminants pose severe risks to human and animal health, with their potential to produce a variety of different toxic effects. Notably, up to 50% of global cereal production is affected by mycotoxin contamination, leading to significant economic losses. Current research focuses on innovative technologies to mitigate mycotoxins, with cold atmospheric pressure plasma emerging as a promising decontamination method.MethodThis systematic review aimed at describing recent advances in the application of cold atmospheric plasma for the decontamination of toxigenic fungi and mycotoxins.Results and discussionCold atmospheric plasma offers a sustainable and cost effective solution to preserve food quality while inactivating toxigenic fungi and degrading mycotoxins. Through the generation of reactive oxygen and nitrogen species, cold plasma disrupts fungal cell integrity, hinders spore germination, and inhibits toxin biosynthesis. Additionally, cold atmospheric plasma-driven degradation of mycotoxins involves structural modifications, breaking key molecular bonds that reduce toxicity. The effectiveness of cold plasma depends on operational parameters and the specific characteristics of the treated food, with notable efficacy in degrading aflatoxin B1 and deoxynivalenol by converting them into less toxic substances and inhibiting their spores and DNA responsible for their biosynthesis. While the data demonstrates that cold atmospheric plasma has minimal impact on food composition, further research is needed to fully assess the nature of the degradation products of mycotoxins, its influence on food quality attributes and to optimize application strategies for different products.
Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer’s disease
Authors: Kollarik Sedef , Bimbiryte Dorita , Sethi Aakriti , Dias Inês , Moreira Carlos G. , Noain Daniela 
Published: January 2025

IntroductionImproving sleep in murine Alzheimer’s disease (AD) is associated with reduced brain amyloidosis. However, the window of opportunity for successful sleep-targeted interventions, regarding the reduction in pathological hallmarks and related cognitive performance, remains poorly characterized.MethodsHere, we enhanced slow-wave activity (SWA) during sleep via sodium oxybate (SO) oral administration for 2 weeks at early (6 months old) or moderately late (11 months old) disease stages in Tg2576 mice and evaluated resulting neuropathology and behavioral performance.ResultsWe observed that the cognitive performance of 6-month-old Tg2576 mice significantly improved upon SO treatment, whereas no change was observed in 11-month-old mice. Histochemical assessment of amyloid plaques demonstrated that SO-treated 11-month-old Tg2576 mice had significantly less plaque burden than placebo-treated ones, whereas ELISA of insoluble protein fractions from brains of 6-month-old Tg2576 mice indicated lower Aβ-42/Aβ-40 ratio in SO-treated group vs. placebo-treated controls.DiscussionAltogether, our results suggest that SWA-dependent reduction in brain amyloidosis leads to alleviated behavioral impairment in Tg2576 mice only if administered early in the disease course, potentially highlighting the key importance of early sleep-based interventions in clinical cohorts.
Minimal differences observed when comparing the morphological profiling of microglia obtained by confocal laser scanning and optical sectioning microscopy
Authors: Godeanu Sânziana , Mușat Mădălina Iuliana , Scheller Anja , Osiac Eugen , Cătălin Bogdan 
Published: January 2025

BackgroundWhile widefield microscopy has long been constrained by out-of-focus scattering, advancements have generated a solution in the form of confocal laser scanning microscopy (cLSM) and optical sectioning microscopy using structured illumination (OSM). In this study, we aim to investigate, using microglia branching, if cLSM and OSM can produce images with comparable morphological characteristics.ResultsBy imaging the somatosensory microglia from a tissue slice of a 3-week-old mouse and establishing morphological parameters that characterizes the microglial branching pattern, we were able to show that there is no difference in total length of the branch tree, number of branches, mean branch length and number of primary to terminal branches. We did find that area-based parameters such as mean occupied area and mean surveillance area were bigger in cLSM isolated microglia compared to OSM ones. Additionally, by investigating the difference in acquisition time between techniques and personal costs we were able to establish that the amortization could be made in 6.11 ± 2.93 years in the case of countries with a Human Development Index (HDI) = 7–9 and 7.06 ± 3.13 years, respectably, for countries with HDI &lt; 7. As such, OSM systems seem a valid option if one just wants basic histological evaluation, and cLSM should be considered for groups that demand higher resolution or volumetric images.
Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads
Authors: Machetanz Kathrin , Weinbrenner Eliane , Wuttke Thomas Volkmar , Ethofer Silke , Helfrich Randolph , Kegele Josua , Lauxmann Stephan , Alber Michael , Rona Sabine , Tatagiba Marcos , Lerche Holger , Honegger Jürgen , Naros Georgios 
Published: January 2025

ObjectiveEpilepsy is considered as a network disorder of interacting brain regions. The propagation of local epileptic activity from the seizure onset zone (SOZ) along neuronal networks determines the semiology of seizures. However, in highly interconnected brain regions such as the insula, the association between the SOZ and semiology is blurred necessitating invasive stereoelectroencephalography (SEEG). Normative connectomes on MRI data enable to link different symptoms and lesion locations to a common functional network. The present study applied connectomics to disentangle epilepsy networks from insular SEEG recordings and to describe their relationship to seizure semiology.MethodsWe retrospectively extracted functional networks by normative connectome analysis from 118 insular contacts depicting epileptic discharges during SEEG in 20 epilepsy patients. The resulting epilepsy networks were correlated to the corresponding semiology by voxel-wise regression and multivariate analyses of variances.ResultsEpileptic foci were found in the posterior insula for somatosensory, other sensory and motor seizures, while cognitive and autonomic symptoms were related to the anterior insula. We identified insular connections to the superior temporal gyrus and heschl gyrus in sensory seizures and projections to the somatosensory cortex in somatosensory seizures. Insula-basal ganglia pathways were found in cognitive seizure manifestations, while insular connectivity to fronto-basal regions were strongest in patients with autonomic seizures.ConclusionThe semiology of seizures is mirrored in the functional connectivity of insular epileptic discharges. Combining SEEG and connectomics could provide additional information about seizure propagation within the epilepsy network and might enable new treatment options in the future like deep brain stimulation.
Medial and lateral vestibulospinal projections to the cervical spinal cord of the squirrel monkey
Authors: Boyle Richard 
Published: January 2025

IntroductionThe brainstem vestibular nuclei neurons receive synaptic inputs from inner ear acceleration-sensing hair cells, cerebellar output neurons, and ascending signals from spinal proprioceptive-related neurons. The lateral (LVST) and medial (MVST) vestibulospinal (VS) tracts convey their coded signals to the spinal circuits to rapidly counter externally imposed perturbations to facilitate stability and provide a framework for self-generated head movements.MethodsThe present study describes the morphological characteristics of intraaxonally recorded and labeled VS neurons monosynaptically connected to the 8th nerve. The visualization of axon location in the descending medial longitudinal fasciculus (MLF) differentiated ipsi- (i) and contralateral (c)-projecting MVST neurons. Vestibuloocular collic (VOC) neurons were comparably typed as cMVST cells but were also antidromically activated from the rostral MLF. Cervical-only LVST neurons projected ipsilaterally in the lateral to ventrolateral funiculi. Targets of VS axons, such as central cervical nucleus neurons, sternocleidomastoid, trapezius, and splenius motoneurons, were identified using anti- and orthodromic electrical stimuli and intra-somatically labeled to describe their local spinal morphology.ResultsThirty-five VS neurons (26% of the 134 attempted samples) were successfully labeled to permit a moderate to (near) complete reconstruction of their trajectories and synaptic innervations. VOC neurons exhibited a prolific innervation of caudal brainstem nuclei, extensively innervated laminae VII and VIII, and, to a lesser extent, lateral and ventromedial lamina IX, from C1 to C8, and on average issued 15 branches along their trajectory with 92 terminal and en passant boutons per branch. The VOC innervation was either uniformly distributed among the cervical segments, indicating a more global control of head and neck movement, or restricted specific spinal segments, indicating a more precise motor control strategy. The innervation pattern of iMVST axons resembled that of VOC and cMVST axons but was less extensive and supplied mostly the upper two cervical segments. LVST and cMVST neurons exhibited a predominantly equally weighted innervation of separate and joint moto- and inter-neuronal spinal circuits along their cervical trajectory.DiscussionTheir extensive axon branching distribution in the ventral horn provides a redundant and variable synaptic input to spinal cell groups. This suggests a common and site-specific control of the head and neck reflexes.
Dietary diversity and its associated factors among school children in conflict affected communities of southern Ethiopia
Authors: Yakob Tagese , Israel Eskinder , Yakob Begidu , Meshesha Mekdes , Jambo Endale , Utalo Tadewos , Abraham Awoke 
Published: January 2025

BackgroundGlobally, more than 815 million estimated people worldwide suffer from malnutrition or are unable to access enough food due to malnutrition. Conflict remains the single most fundamental factor contributing to chronic malnutrition in the conflict-affected areas. Developing a healthy and balanced dietary pattern is essential for school children because their habits in this period may last longer. Therefore, the current study aimed to assess dietary adequacy level and factors associated among school children in conflicts affected communities of southern Ethiopia.Method and materialsA community-based cross-sectional study was conducted among 616 schoolchildren aged 6 to 12 years with their caregivers using a multistage sampling method. The data were collected by using a structured questionnaire. The data were collected and entered into Epi-data version 4.6.0.2 and exported to STATA software version 14 for analysis. Adequate dietary diversity was defined as the consumption of at least five food groups. Both bivariable and multivariable binary logistic regression were performed. A p-value less than 0.05 on multivariate logistic regression indicated a statistically significant association.ResultsThe overall response rate of this study was 98.5%. The median [inter quartile range (IQR)] dietary diversity score of the studies was 4(3–5) with the prevalence of inadequate dietary diversity among the school children of current study was 59.4% (95% CI, 55.17–62.99). In this study, schoolchildren with no near-health care facility (AOR = 1.95, 95% CI; 1.35–2.82), a family size greater than five (AOR = 1.44, 95% CI; 1.01–2.05), and the absence of a family home garden (AOR = 1.55, CI: 1.35–1.83) were significantly associated with low dietary diversity in school children.ConclusionWhen compared with other studies, dietary diversity in the current study area was low. This emphasizes the need to encourage mothers to use family planning and implementing focused public health interventions, such school lunch programs and community gardening projects, to improve children’s nutritional outcomes and dietary diversity.
Improve the quality of end-of-life in cancer patients using social representations of nutrition
Authors: Llinares-Insa Lucia Inmaculada , Chisbert-Alapont Encarna , Benedito-Monleón María Amparo , González-Navarro Pilar 
Published: January 2025

IntroductionThe problems related to nutrition generate great concern in palliative cancer patients and their caregivers. Literature has analyzed the psychological and social problems that nutrition causes. From patient-centered orientation, there are protocols for nutritional care. This psycho-health information is a source of discomfort among patients and families and its absence generates many problems related to nutrition with negative clinical repercussions. Thus, this study aims to analyze the concept of nutrition in advanced cancer patients with palliative care and their caregivers. Furthermore, given that food has an important cultural component as important as it is nutrition, the sociocultural influence on the social representation of nutrition will also be analyzed.MethodsThe study design was qualitative and cross-sectional with a recruitment period lasting 18 months. After the informed consent, a sample of advanced cancer patients (N=57) and their caregivers (N=57) were interviewed individually. The data was analyzed using content analysis and descriptive analysis. The existence of statistical differences between groups (patients and caregivers) was tested by Chi-Square statistics.ResultsResults showed that the perception of nutrition was structured in five categories: health/survival/life (e.g. “healthy”), social relationship (e.g. “intimate relationship”), care (e.g. “care role”), foodstuff (e.g. “vegetables”), and others (“anything”). There were significant differences (p-Value&gt;0.05) in the uses of nutrition between patients and their caregivers and caregivers had higher scores. Then, nutrition was perceived as an act of care and, therefore, patients were expected to strive to eat despite the loss of appetite.DiscussionThis study is one of the first to explore the perception of nutrition emphasize the insufficient consideration of patients’ and caregivers’ needs and perceptions regarding food, as well as the significance of this knowledge in patient-centered care approaches. In this way, it could intervene by first understanding the behavior concerning food and, secondly, redirecting the behavior if it is harmful to the patient or family relationships regarding the health care and well-being of patients with advanced cancer with palliative care.