bluuebunny/crossref_metadata_2025_split huggingface dataset:
Er:YAG laser-induced damage to a dental composite in simulated clinical scenarios for inadvertent irradiation: an in vitro study
Authors: Kuhn Katharina , Schmid Carmen U. , Luthardt Ralph G. , Rudolph Heike , Diebolder Rolf 
Published: July 2021

AbstractInadvertent Er:YAG laser irradiation occurs in dentistry and may harm restorative materials in teeth. The aim of this in vitro study was to quantify Er:YAG laser-induced damage to a nanohybrid composite in simulated clinical scenarios for inadvertent direct and indirect (reflection) laser irradiation. The simulation was performed by varying the output energy (OE;direct˃indirect) reaching the specimen and the operating distance (OD;direct˂indirect). Composite specimens were irradiated by an Er:YAG laser. The ablation threshold was determined and clinically relevant parameters were applied (n = 6 for each OE/OD combination) for direct (OE: 570 mJ/OD: 10 mm, OE: 190 mJ/OD: 10 mm) and indirect irradiation (OE: 466 mJ/OD: 15 mm, OE: 57 mJ/OD: 15 mm, OE: 155 mJ/OD: 15 mm, OE: 19 mJ/OD: 15 mm). The extent of damage in the form of craters was evaluated using a laser scanning microscope (LSM) and a conventional light microscope (LM). The ablation threshold was determined to be 2.6 J/cm2. The crater diameter showed the highest value (LM: 1075 ± 18 µm/LSM: 1082 ± 17 µm) for indirect irradiation (reflectant:dental mirror) (OE: 466 mJ/OD: 15 mm). The crater depth showed the highest and comparable value for direct (OE: 570 mJ/OD: 10 mm; LSM: 89 ± 2 µm) and indirect irradiation (OE: 466 mJ/OD: 15 mm; LSM: 90 ± 4 µm). For each OD, the crater diameter, depth, and volume increased with higher laser fluence. However, the OD—and thus the laser spot diameter—also had an enlarging effect. Thus, indirect irradiation (reflectant:dental mirror) with only 47% of the laser fluence of direct irradiation led to a larger diameter and a comparable depth. The three-dimensional extent of the crater was large enough to cause roughening, which may lead to plaque accumulation and encourage caries, gingivitis, and periodontitis under clinical conditions. Clinicians should be aware that reflected irradiation can still create such craters.
Delivering PrEP to Young Women in a Low-Income Setting in South Africa: Lessons for Providing Both Convenience and Support
Authors: Cassidy Tali , Ntuli Nelisiwe , Kilani Charllen , Malabi Nikiwe , Rorwana Bulelwa , Mutseyekwa Tabitha , O’Connell Rebecca , Steele Sarah Jane , Ndlovu Zee , Ellman Tom , de Azevedo Virginia , Pfaff Colin , Nelson Aurelie , Duran Laura Trivino 
Published: July 2021

AbstractDaily oral pre-exposure prophylaxis (PrEP) is a key tool in addressing high HIV incidence among young women, and breaking the cycle of transmission. From 2017 to 2020, Médecins Sans Frontières (MSF) offered PrEP, in conjunction with contraception and risk-reduction counselling, to women aged 18–25, in a government-run clinic in Khayelitsha, a low income high HIV prevalence area in South Africa. Drawing on clinical, quantitative, and qualitative interview data, we describe participants’ experiences and engagement with the PrEP program, participant adherence (measured by TFV-DP levels in dried blood spots) over time, and the indirect benefits of the PrEP program. Of 224 screened and eligible participants, 164 (73.2%) initiated PrEP, with no large differences between those who initiated and those who did not. Overall, 47 (29%) completed 18 months follow-up, with 15 (9.1%) attending all visits. 76 (46.9%) participants were lost to follow-up, 15 (9.1%) exited when leaving the area, and 28.7% of exits happened in the first month of the study. We identified two different trajectories of PrEP adherence: 67% of participants had, on average, consistently low TFV-DP levels, with the remaining 33% having sustained high adherence. Few baseline characteristics predicted good adherence. The main reported barrier to taking PrEP was forgetting to take or travel with the pills. Encouragement from others declined as a reported facilitator from month 6 to 18 (family: 93.1% vs 77.6%, p = 0.016, friends: 77.6% vs 41.4%, p ≤ 0.001, partners: 62.1% vs 46.6%, p = 0.096, other PrEP users: 89.7% vs 74.1%, p = 0.020). Disclosure to friends and family in some cases opened dialogue around sex, and helped to educate others about PrEP. Self-reported sex with more than one partner, and sex without a condom, decreased significantly after enrolment (p < 0.001, p = 0.063). In the individual interviews, participants credited their PrEP experience with changing their behaviour. Recognising the challenges with, but overall benefits from a package of care that includes the option of PrEP, lessons drawn from this study can help maximise persistence on PrEP within resource constraints. PrEP providers need to address participants’ need for both convenience and social support.
Type of broadleaf forest matters most for ptyctimous mite communities (Acari, Oribatida) in Norway
Authors: Seniczak Anna , Niedbała Wojciech , Iturrondobeitia J. Carlos , Seniczak Stanisław , Roth Steffen , Jordal Bjarte H. 
Published: July 2021

AbstractWe studied ptyctimous moss mites, which are characteristic of forest habitats, in Norwegian broadleaf forests considered as biodiversity hotspot areas in Fennoscandia. The study aimed to evaluate the effect of different factors (regional locality, annual precipitation, mean annual temperature, forest type, forest wetness and microhabitat) on the ptyctimous mites and on discovering their richness in broadleaf forests. Samples were collected from nine broadleaf forests in Western, Southern and Eastern Norway, in different climatic conditions, six forest types, three forest wetness states and eight microhabitats. Overall, 3341 ptyctimous mites were collected and their abundance differed significantly among the regions, forest types and microhabitats. Forest type turned out to be the most important factor, responsible for 24.5% of the total variation in the abundance of the ptyctimous mites. Other important factors were forest wetness and microhabitat. In total, 27 species, i.e., 87% of all ptyctimous mites known from before in Norway were found and the species richness was highest in the east and lowest in the west of the country.Atropacarus (Atropacarus) striculuswas most common and most abundant; it made nearly 30% of all ptyctimous mites collected. On the other hand, a quarter of the species were represented by less than 10 specimens; most of these were new records for Norway. Among ten species discovered as new to Norway, four were also new to Fennoscandia. These findings confirm the unique character and high biological diversity of Norwegian broadleaf forests.
Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors
Authors: Denlinger Crystal S. , Keedy Vicki L. , Moyo Victor , MacBeath Gavin , Shapiro Geoffrey I. 
Published: July 2021

SummaryBackground Overactivation of human epidermal growth factor receptor 3 (HER3) triggers multiple intracellular pathways resulting in tumor cell survival. This Phase 1 study assessed the safety, efficacy, and pharmacokinetics (PK) of seribantumab, a fully human anti-HER3 monoclonal antibody. Methods Adult patients with advanced or refractory solid tumors were treated in six dose cohorts of seribantumab: 3.2, 6, 10, 15, or 20 mg/kg weekly, or 40 mg/kg loading dose followed by 20 mg/kg weekly maintenance dose (40/20 mg/kg) using a modified 3 + 3 dose escalation strategy with cohort expansion. Primary objectives were identification of a recommended Phase 2 dose (RP2D) and determination of objective response rate. Secondary objectives were assessment of safety, dose-limiting toxicities, and PK. Results Forty-four patients (26 dose escalation; 18 dose expansion) were enrolled. Seribantumab monotherapy was well tolerated with most adverse events being transient and mild to moderate (grade 1 or 2) in severity; maximum tolerated dose was not reached. The highest dose, 40/20 mg/kg, was identified as RP2D. Best response was stable disease, reported in 24% and 39% of patients during the dose escalation and expansion portions of the study, respectively. Seribantumab terminal half-life was ≈100 h; steady state concentrations were reached after 3–4 weekly doses. Conclusions Seribantumab monotherapy was well tolerated across all dose levels. Safety and PK data from this study support further seribantumab investigations in genomically defined populations.Clinical trial registration NCT00734305. August 12, 2008.
Risk stratification in cardiogenic shock: a focus on the available evidence
Authors: Sciaccaluga C. , Mandoli G. E. , Ghionzoli N. , Anselmi F. , Dini C. Sorini , Righini F. , Cesareo F. , D’Ascenzi F. , Focardi M. , Valente S. , Cameli M. 
Published: July 2021

AbstractCardiogenic shock is a clinical syndrome which is defined as the presence of primary cardiac disorder that results in hypotension together with signs of organ hypoperfusion in the state of normovolaemia or hypervolaemia. It represents a complex life-threatening condition, characterized by a high mortality rate, that requires urgent diagnostic assessment as well as treatment; therefore, it is of paramount important to advocate for a thorough risk stratification. In fact, the early identification of patients that could benefit the most from more aggressive and invasive approaches could facilitate a more efficient resource allocation. This review attempts to critically analyse the current evidence on prognosis in cardiogenic shock, focusing in particular on clinical, laboratoristic and echocardiographic prognostic parameters. Furthermore, it focuses also on the available prognostic scores, highlighting the strengths and the possible pitfalls. Finally, it provides insights into future direction that could be followed in order to ameliorate risk stratification in this delicate subset of patients.
Fighting Insurgency, Ruining the Environment: the Case of Forest Fires in the Dersim Province of Turkey
Authors: Dinc Pinar , Eklund Lina , Shahpurwala Aiman , Mansourian Ali , Aturinde Augustus , Pilesjö Petter 
Published: July 2021

AbstractEnvironmental destruction has long been used as a military strategy in times of conflict. A long-term example of environmental destruction in a conflict zone can be found in Dersim/Tunceli province, located in Eastern Turkey. In the last century, at least two military operations negatively impacted Dersim’s population and environment: 1937–38 and 1993–94. Both conflict and environmental destruction in the region continued after the 1990s. Particularly after July 2015, when the brief peace process that began in 2013 ended, conflict between the Turkish state and the Kurdistan Workers’ Party (PKK) resumed and questions arose about the cause of forest fires in Dersim. In this research we investigate whether there is a relationship between conflict and forest fires in Dersim. This is denied by the Turkish state but asserted by many Dersim residents, civil society groups, and political parties. We use a multi-disciplinary approach, combining methods of qualitative analysis of print media (newspapers), social media (Twitter), and local accounts, together with quantitative methods: remote sensing and spatial analysis. Interdisciplinary analysis combining quantitative datasets with in-depth, qualitative data allows a better understanding of the role of conflict in potentially exacerbating the frequency and severity of forest fires. Although we cannot determine the cause of the fires, the results of our statistical analysis suggest a significant relationship between fires and conflict in Dersim, indicating that the incidence of conflicts is generally correlated with the number of fires.
Chronically Activated T-cells Retain Their Inflammatory Properties in Common Variable Immunodeficiency
Authors: Berbers Roos-Marijn , van der Wal M. Marlot , van Montfrans Joris M. , Ellerbroek Pauline M. , Dalm Virgil A. S. H. , van Hagen P. Martin , Leavis Helen L. , van Wijk Femke 
Published: July 2021

Abstract
Purpose
Immune dysregulation complications cause significant morbidity and mortality in common variable immunodeficiency (CVID), but the underlying pathophysiology is poorly understood. While CVID is primarily considered a B-cell defect, resulting in the characteristic hypogammaglobulinemia, T-cells may also contribute to immune dysregulation complications. Here, we aim to further characterize T-cell activation and regulation in CVID with immune dysregulation (CVIDid).

Methods
Flow cytometry was performed to investigate T-cell differentiation, activation and intracellular cytokine production, negative regulators of immune activation, regulatory T-cells (Treg), and homing markers in 12 healthy controls, 12 CVID patients with infections only (CVIDio), and 20 CVIDid patients.

Results
Both CD4 + and CD8 + T-cells in CVIDid showed an increased activation profile (HLA-DR + , Ki67 + , IFNγ +) when compared to CVIDio, with concomitant upregulation of negative regulators of immune activation PD1, LAG3, CTLA4, and TIGIT. PD1 + and LAG3 + subpopulations contained equal or increased frequencies of cells with the capacity to produce IFNγ, Ki67, and/or GzmB. The expression of PD1 correlated with serum levels of CXCL9, 10, and 11. Treg frequencies were normal to high in CVIDid, but CVIDid Tregs had reduced CTLA-4 expression, especially on CD27 + effector Tregs. Increased migratory capacity to inflamed and mucosal tissue was also observed in CVIDid T-cells.

Conclusion
CVIDid was characterized by chronic activation of peripheral T-cells with preserved inflammatory potential rather than functional exhaustion, and increased tissue migratory capacity. While Treg numbers were normal in CVIDid Tregs, low levels of CTLA-4 indicate possible Treg dysfunction. Combined studies of T-cell dysfunction and circulating inflammatory proteins may direct future treatment strategies.
Alexithymia and Emotion Regulation Strategies in Adolescent Gamblers with and Without At-Risk Profiles
Authors: Estévez Ana , Jauregui Paula , Macía Laura , Martín-Pérez Cristina 
Published: July 2021

AbstractAlexithymia, difficulties in emotion regulation, and negative affect play an important role in adolescents who present pathological gambling. Therefore, the objectives of the present study were, firstly, to analyze the differences between alexithymia, difficulties in emotion regulation, and positive and negative affect in adolescents with and without risk of gambling problems. Secondly, the relationships between all the variables of the study in adolescents with and without risk of problem gambling were analyzed separately. Thirdly, we analyzed the mediating role of positive and negative affect in the relationship between alexithymia and dysfunctional emotion regulation strategies (ERS) in adolescents at risk of gambling problems. The sample was composed of 206 adolescents with ages ranging from 12 to 18 years (M = 15.52; SD = 1.43). They were divided into two groups according to the score obtained in the South Oaks Gambling Screen-Revised for Adolescents (SOGS-RA). Thus, 84 were included in the group without risk of gambling problems and 122 in the group at risk of gambling problems. The results obtained revealed higher scores in negative affect and pathological gambling in the group at risk of gambling problems. Likewise, positive relationships between alexithymia, maladaptive emotion regulation strategies (MERS), and affect were found. Mediation analyses showed that difficulties in identifying feelings were indirectly related to greater use of dysfunctional ERS through their relationship with negative affect in at-risk gamblers.
Computing Dynamic User Equilibrium on Large-Scale Networks Without Knowing Global Parameters
Authors: Thong Duong Viet , Gibali Aviv , Staudigl Mathias , Vuong Phan Tu 
Published: July 2021

AbstractDynamic user equilibrium (DUE) is a Nash-like solution concept describing an equilibrium in dynamic traffic systems over a fixed planning period. DUE is a challenging class of equilibrium problems, connecting network loading models and notions of system equilibrium in one concise mathematical framework. Recently, Friesz and Han introduced an integrated framework for DUE computation on large-scale networks, featuring a basic fixed-point algorithm for the effective computation of DUE. In the same work, they present an open-source MATLAB toolbox which allows researchers to test and validate new numerical solvers. This paper builds on this seminal contribution, and extends it in several important ways. At a conceptual level, we provide new strongly convergent algorithms designed to compute a DUE directly in the infinite-dimensional space of path flows. An important feature of our algorithms is that they give provable convergence guarantees without knowledge of global parameters. In fact, the algorithms we propose are adaptive, in the sense that they do not need a priori knowledge of global parameters of the delay operator, and which are provable convergent even for delay operators which are non-monotone. We implement our numerical schemes on standard test instances, and compare them with the numerical solution strategy employed by Friesz and Han.
Model order reduction based on direct normal form: application to large finite element MEMS structures featuring internal resonance
Authors: Opreni Andrea , Vizzaccaro Alessandra , Frangi Attilio , Touzé Cyril 
Published: July 2021

AbstractDimensionality reduction in mechanical vibratory systems poses challenges for distributed structures including geometric nonlinearities, mainly because of the lack of invariance of the linear subspaces. A reduction method based on direct normal form computation for large finite element (FE) models is here detailed. The main advantage resides in operating directly from the physical space, hence avoiding the computation of the complete eigenfunctions spectrum. Explicit solutions are given, thus enabling a fully non-intrusive version of the reduction method. The reduced dynamics is obtained from the normal form of the geometrically nonlinear mechanical problem, free of non-resonant monomials, and truncated to the selected master coordinates, thus making a direct link with the parametrisation of invariant manifolds. The method is fully expressed with a complex-valued formalism by detailing the homological equations in a systematic manner, and the link with real-valued expressions is established. A special emphasis is put on the treatment of second-order internal resonances and the specific case of a 1:2 resonance is made explicit. Finally, applications to large-scale models of micro-electro-mechanical structures featuring 1:2 and 1:3 resonances are reported, along with considerations on computational efficiency.
Do equidistant energy levels necessitate a harmonic potential?
Authors: Teichert Fabian , Kuhn Eduard , Thränhardt Angela 
Published: July 2021

AbstractExperimental results from literature show equidistant energy levels in thin Bi films on surfaces, suggesting a harmonic oscillator description. Yet this conclusion is by no means imperative, especially considering that any measurement only yields energy levels in a finite range and with a nonzero uncertainty. Within this study we review isospectral potentials from the literature and investigate the applicability of the harmonic oscillator hypothesis to recent measurements. First, we describe experimental results from literature by a harmonic oscillator model, obtaining a realistic size and depth of the resulting quantum well. Second, we use the shift-operator approach to calculate anharmonic non-polynomial potentials producing (partly) equidistant spectra. We discuss different potential types and interpret the possible modeling applications. Finally, by applying nth order perturbation theory we show that exactly﻿ equidistant eigenenergies cannot be achieved by polynomial potentials, except by the harmonic oscillator potential. In summary, we aim to give an overview over which conclusions may be drawn from the experimental determination of energy levels and which may not.
The Transition to a Coresidential Partnership: Who Moves and Who Has the Partner Move In?
Authors: Krapf Sandra , Mulder Clara H. , Wagner Michael 
Published: July 2021

AbstractMoving into a joint household is an important step in the process of union formation. While a growing body of literature investigates differences between those couples who start coresidence and those who do not, we know little about the likelihood of moving upon the start of coresidence. The aim of this paper is to investigate how individual and couple-level characteristics are associated with moving, or having a partner move in, at the start of coresidence. We use data from 10 waves of the German Family Panel pairfam for those who started coresidence (n = 983) and estimate logistic regression models of moving versus having a partner move in. The respondents in the sample are quite young with a mean age of 27. For long-distance relationships, those with a higher level of education than their partner and women who were living in close proximity to their parents were less likely to move. In short-distance relationships, respondents living in the parental home or in crowded housing were more likely to move than those living in uncrowded housing. In contrast with previous research, we did not find that women were more likely to move than men. Our results highlight that factors like educational resources, housing demands, and local family ties have differential effects on moving decisions at the start of coresidence depending on the distance moved.
Making legacy Fortran code type safe through automated program transformation
Authors: Vanderbauwhede Wim 
Published: July 2021

AbstractFortran is still widely used in scientific computing, and a very large corpus of legacy as well as new code is written in FORTRAN 77. In general this code is not type safe, so that incorrect programs can compile without errors. In this paper, we present a formal approach to ensure type safety of legacy Fortran code through automated program transformation. The objective of this work is to reduce programming errors by guaranteeing type safety. We present the first rigorous analysis of the type safety of FORTRAN 77 and the novel program transformation and type checking algorithms required to convert FORTRAN 77 subroutines and functions into pure, side-effect free subroutines and functions in Fortran 90. We have implemented these algorithms in a source-to-source compiler which type checks and automatically transforms the legacy code. We show that the resulting code is type safe and that the pure, side-effect free and referentially transparent subroutines can readily be offloaded to accelerators.