bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular Inflammation and Cardiovascular Burden in Metastatic Breast Cancer Female Patients Receiving Hormonal Treatment and CDK 4/6 Inhibitors or Everolimus
Authors: Papageorgiou Christos , Zagouri Flora , Tampakis Konstantinos , Georgakopoulou Rebecca , Manios Efstathios , Kafouris Pavlos , Benetos Georgios , Koutagiar Iosif , Anagnostopoulos Constantinos , Dimopoulos Meletios A. , Toutouzas Konstantinos 
Published: February 2021

Background: Chemotherapy regimens for breast cancer treatment can promote vascular dysfunction and lead to high cardiovascular risk.Purpose: To investigate the cardiovascular burden and vascular inflammation in metastatic breast cancer patients receiving CDK 4/6 inhibitors or everolimus in addition to standard hormonal treatment.Methods: 22 consecutive female patients with metastatic breast cancer were enrolled. Relative wall thickness (RWT) and left ventricle mass (LVM) measurements by transthoracic echocardiography were obtained followed by 24-h ambulatory blood pressure monitoring, and 18F-fluorodeoxyglucose positron-emission tomography/computed tomography imaging. Uptake of the radiotracer in the aortic wall was estimated as tissue-to-background ratio (TBR). Each patient was assessed for the aforementioned parameters before the initiation and after 6 months of treatment.Results: At follow up, patients assigned to CDK 4/6 treatment demonstrated increased 24-h systolic blood pressure (SBP) (p = 0.004), daytime SBP (p = 0.004) and night time SBP (p = 0.012) (Group effect). The 24-h mean arterial pressure measurements were also higher in CDK 4/6 population, in comparison to everolimus that displayed firm values (Group effect- p = 0.035, Interaction effect-p = 0.023). Additionally, 24 h diastolic blood pressure recordings in CDK 4/6 therapy were higher opposed to everolimus that remained consistent (Interaction effect- p = 0.010). In CDK 4/6 group, TBR aorta also increased significantly, whereas TBR values in everolimus remained stable (Interaction effect-p = 0.049). Both therapeutic regimens displayed statistically significant damaging effect to RWT and LVM.Conclusion: CDK 4/6 inhibitors and hormonal treatment can lead to increased vascular inflammation, and higher blood pressure compared to the combination of everolimus and hormonal treatment. Moreover, both treatment strategies promoted left ventricle remodeling.
The Seismotectonic Significance of Geofluids in Italy
Authors: Vannoli Paola , Martinelli Giovanni , Valensise Gianluca 
Published: February 2021

There is growing interest in how geofluid emissions are released in the atmosphere by the planet’s geodynamic activity, and how much they contribute to the global budget of greenhouse gases. Many workers are addressing this issue with studies conducted at global scale, so as to get the required global-scale answers. The data available at the global scale on geofluids, faults, earthquakes and volcanoes, however, are generally too coarse to provide these answers. We investigate the relationships between geofluid emissions and tectonics at a more detailed scale. Building on over a century of data on geofluid emissions and on an extensive knowledge of the region’s tectonics and seismicity, we focused on Italy, one of the areas of the globe that experience the largest release of natural CO2and CH4. We systematically overlaid and compared data collected by a number of workers into 13 published countrywide databases concerning geofluid emissions, carbon-bearing deposits, seismogenic faults, historical and instrumentally documented earthquakes, and heat flow observations. Our results indicate that 1) thermal springs and CO2emissions dominate in areas of mantle upwelling and crustal stretching, but also that 2) some of them occur in the extending inner Apennines, generally along major lithospheric chain-perpendicular lineaments that bound the largest normal faults. Conversely, 3) CH4emissions and mud volcanoes dominate in areas undergoing active contraction, where no CO2emissions are observed; in particular, we find 4) that mud volcanoes concentrate where the crests of active anticlines intersect major lithospheric chain-perpendicular lineaments. An overarching conclusion is that, in Italy, the release of geofluids is primarily controlled by deep crustal discontinuities that developed over the course of 5–10 My, and is only mildly affected by ongoing crustal strains. Geofluid emissions bring information on processes that occur primarily in the lower crust, marking the surface projection of generally hidden discontinuities that control the geometry and modes of seismic release. As such they may also provide valuable insight for improving the assessment of seismic hazard in hard-to-investigate seismically active regions, such as Italy.
Mexican Onyx Waste as Active Material and Active Material’s Precursor for Conversion Anodes of Lithium Ion Batteries
Authors: Quiroga-González Enrique , Morales-Merino Emma 
Published: February 2021

For the first time a limestone has been used as active material or active material’s precursor for electrodes of Li ion batteries. Limestones are very abundant, what is a condition for a sustainable development of energy storage devices. Mexican onyx has been used as a model of limestone in this work, mainly composed of calcite (calcium carbonate). Waste powder of this material from handcraft production was used, reducing costs. The material was carbonized and pyrolyzed, producing calcium oxide covered with carbon. Mexican onyx either treated or untreated works well as anode material for Li ion batteries, storing charges by conversion. Despite the grains of this material were as big as 50 μm, the material with no treatment showed a maximum Li storage capacity of 530.16 mAh/g at C/3.3, while the pyrolyzed one showed a maximum reversible capacity of 220 mAh/g at 1.37C and of 158 mAh/g at 5.48C, performance even better than the performance of graphite.
Organizational Barriers to Oral Health Conversations Between Health Visitors and Parents of Children Aged 9–12 Months Old
Authors: Eskytė Ieva , Gray-Burrows Kara A. , Owen Jenny , Sykes-Muskett Bianca , Pavitt Sue H. , West Robert , Marshman Zoe , Day Peter F. 
Published: February 2021

Background: Dental caries is the most prevalent preventable childhood disease and a major public health priority. Local authorities in England have a statutory responsibility to improve child health, including oral health, through the “Healthy Child Programme.” The “Healthy Child Programme,” which includes the provision of oral health advice is delivered by health visitors to parents of young children. To date, research has mainly concentrated on individual interactions between health visitors and parents, with less attention given to the broader context in which these oral health conversations between health visitor and parents take place.Objective: Our study explored the organizational factors that obstruct health visitors from engaging in meaningful conversations with parents about young children's oral health.Methods: Qualitative interviews and focus groups were held with health visiting teams (n = 18) conducting home visits with parents of 9–12-month olds in a deprived, urban area in England.Results: The study revealed the wide variation in what and how oral health advice is delivered to parents at home visits. Several barriers were identified and grouped into four key themes: (1) Priority of topics discussed in the home visits; (2) Finance cuts and limited resources; (3) Oral health knowledge and skills; and (4) Collaborative working with other professionals. It was evident that organizational factors in current public health policy and service provision play an important role in shaping oral health practices and opportunities for behavior change.Conclusion: Organizational practices and procedures play an important role in creating interaction patterns between health visiting teams and parents of young children. They often limit effective engagement with and positive change in oral health. For future oral health interventions to be effective, awareness of these barriers is essential alongside them being founded on evidence-based advice and underpinned by appropriate theory.
Study on Ill Effects Caused by Air Pollutants on People at Cement Manufacturing Unit
Authors: S Dhinu priya , G Poovizhi , D Ambika 
Published: February 2021

The cement industry is one of the most polluting industries in the world. It is responsible for emission of pollutants such as particulate matter, carbon dioxide, carbon monoxide, sulphur oxide and nitrogen oxide. It adversely affects the environment and health of the people. It is emitted by burning of pet coke and is higher in concentration due to coalmine wastes and scrap tires. The health effects on people are eye and skin irritation, head ache, respiratory problems, cardio vascular problems and cancer. It also affects pregnant woman which have negative effects such as low birth weight, defects in respiratory system, asthma and allergies. In this paper, the effect of air pollutants from cement manufacturing unit is studied. The areas around cement industry are identified and survey by direct observation is conducted. The pollutants and effects are listed from the observation. The impacts of air pollution on people and their awareness on air pollution are observed. The remedies are suggested to reduce impact on humans.
Impact of Entrepreneurship Activity Sustainable Development
Authors: Huđek Ivona , Hojnik Barbara Bradač 
Published: February 2021

Sustainable development considers the development that achieves the present economic goals, without obstructing the future development in a sense of satisfying the needs of society and endangering the environment. Recently, the entrepreneurship phenomenon has been widely recognized as an important path towards sustainable development, positively contributing to the development of society. Thus, in the paper, the empirical evidence on linkages between entrepreneurial activity indicators and social development goals is provided. To examine the linkages, the data from the Global Entrepreneurship Monitor and Sustainable Development Goals Index were used. The empirical results suggest that entrepreneurship represents an important factor for fostering sustainability, particularly in opportunity-driven and innovative entrepreneurial activities. The results show, that both of them have a positive impact on sustainable development, while the necessity-driven entrepreneurial activity negatively affects sustainable development. This could be explained by the fact that necessity entrepreneurs are not likely to become the entrepreneurs to implement a promising business opportunity, but rather to earn an income. To achieve the sustainable development goals as well as entrepreneurship should become the national priority by introducing new policies and measures, that is, making the conditions, through which entrepreneurship could achieve positive contributions to the development of the society.
PROSPEK KELAYAKAN PENGEMBANGAN BUDIDAYA IKAN NILA DI KOLAM AIR TENANG DI KECAMATAN SINJAI BORONG KABUPATEN SINJAI
Authors: Saleh Jamaluddin , Budi Sutia , Salam Suryawati 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui tingkat kelayakan dan prospek pengembangan budidaya ikan nila di kolam air tenang di Kecamatan Sinjai Borong Kabupaten Sinjai. Populasi dalam penelitian ini adalah pembudidaya ikan nila di kolam air tenang yang ada di Kecamatan Sinjai Borong Kabupaten Sinjai yaitu sebanyak 163 orang pembudidaya, sampelnya sebanyak 30 orang responden ditentukan dengan menggunakan metode purposive sampling berdasarkan pengetahuan dan pengalaman dalam pengelolaan usaha pembesaran ikan nila di kolam air tenang. Data yang yang diperoleh dianalisis dari aspek teknis, aspek finansial, dianalisis dengan analisis SWOT dan analisis trend produksi menggunakan metode kuadrat terkecil. Hasil penelitian menunjukkan bahwa dari aspek teknis layak untuk dikembangkan, aspek finansial tidak layak untuk kelayakan investasi dan Analisis SWOT menunjukkan pada posisi dapat dipertahankan untuk dikembangkan dengan memanfaatkan peluang yang ada dengan meminimalkan ancaman dan kelemahan. Hasil analisis trend menunjukkan bahwa produksi ikan nila memiliki kecenderungan terus meningkat meskipun tidak signifikan.

This research is a case study that aims to determine the level of feasibility and prospects for the development of tilapia aquaculture in calm water ponds in Sinjai Borong Sub-District, Sinjai Regency. The population in this study were tilapia fish farmers in calm water ponds in Sinjai Borong District, Sinjai Regency, as many as 163 farmers, the sampel of 30 respondent was determined using a purposive sampling method based on knowledge and experience in managing of tilapia enlargement business in calm water ponds. The study was conducted in June to July 2019. The data obtained were analyzed from technical aspects, analyzed by SWOT analysis and production trend analysis using the least squares method. The results showed that from the technical aspects feasible to be developed, the financial aspects were not feasible for investment feasibility and the SWOT analysis showed that position could be maintained to be developed by utilizing existing opportunities by minimizing threats and weaknesses. The results of ternd analysis show the tilapia production has a tendency to increase even though it is not significant.
DETERMINAN EMPLOYEE ENGAGEMENT SERTA PENGARUHNYA TERHADAP KINERJA APARAT SIPIL NEGARA PADA DINAS SOSIAL PROVINSI SULAWESI SELATAN
Authors: Malik Indah Fitriani , Remmang Hasanuddin , Said Miah 
Published: February 2021

Penelitian ini bertujuan untuk mengkaji, menganalisis dan menginterpretasi, pengaruh lingkungan kerja, kepemimpinan, dan kompensasi terhadap kinerja aparat sipil negera (ASN) pada Dinas Sosial Provinsi Sulawesi Selatan melalui Employee Engagement. Penelitian ini bersifat kuantitatif dan menggunakan metode survey. Sampel dalam penelitian ini adalah 200 ASN pada Dinas Sosial Provinsi Sulawesi Selatan. Metode pengumpulan data menggunakan kuesioner dan studi pustaka. Data hasil penelitian akan dianalisis melalui alat uji statistik dengan menggunakan software AMOS 23. Hasil penelitian, menunjukkan bahwa: 1) Lingkungan kerja secara langsung maupun tidak langsung tidak berpengaruh signifikan terhadap kinerja ASN Pada Dinas Sosial Provinsi Sulawesi Selatan melalui Employee Engagement 2) Kepemimpinan secara langsung maupun tidak langsung berpengaruh positif dan signifikan terhadap kinerja ASN Pada Dinas Sosial Provinsi Sulawesi Selatan melalui Employee Engagement 3) Kompensasi secara langsung maupun tidak langsung berpengaruh positif dan signifikan terhadap kinerja ASN Pada Dinas Sosial Provinsi Sulawesi Selatan melalui Employee Engagement.
This study aims to examine, analyze and interpret, the effect of the work environment, leadership, and compensation on state civil apparatus (ASN) performance in the Dinas Sosial of the Province of South Sulawesi through Employee Engagement. This research is quantitative and uses survey methods. The sample in this study was 200 ASN at the Dinas Sosial of South Sulawesi Province. Data collection methods used questionnaires and literature study. The data will be analyzed through a statistical test tool using AMOS 23 software. The results of the study show that: 1) Work environment directly or indirectly has no significant effect on ASN performance in the Dinas Sosial of South Sulawesi Province through Employee Engagement; 2) Leadership directly and indirectly has a positive and significant effect on the performance of ASN performance in the Dinas Sosial of South Sulawesi Province through Employee Engagement 3) Compensation directly or indirectly has a positive and significant effect on the performance of ASN performance in the Dinas Sosial of South Sulawesi Province through Employee Engagement.
Pengaruh Alat Peraga Mobil Garis Bilangan terhadap Hasil Belajar Matematika Peserta Didik Kelas VI SD Negeri 6 Klablim
Authors: Alman Alman , Pulung Julisa Palaribato , Astutik Heny Sri 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan alat peraga mobil garis bilangan terhadap hasil belajar operasi hitung bilangan bulat peserta didik. Metode yang digunakan dalam penelitian ini adalah metode pra eksperimen dengan desain penelitian One Shot Case Study Design. Data menunjukkan rata-rata skor observasi guru (peneliti) dan peserta didik sebesar 100% dengan kriteria sangat baik. Hasil analisis ketuntasan belajar pada nilai rata – rata posttest 69,13. Uji normalitas hasil belajar postest peserta didik memiliki taraf signifikansi 0,200 > 0,05. Uji hipotesis diperoleh thitung sebesar 3,712 dengan dk = n – 1 (23-1=22) diperoleh ttabel sebesar 1.717. Berdasarkan hasil analisi data nilai yaitu thitung > ttabel (3.712 > 1.717), dengan besarnya taraf signifikansi 0,05, yakni (0,001 < 0,05) maka Hipotesis diterima, Dengan demikian dapat disimpulkan bahwa terdapat pengaruh alat peraga mobil garis bilangan terhadap hasil belajar matematika materi operasi hitung bilangan bulat pada peserta didik kelas VI SD Negeri 6 Klablim Kota Sorong.
Penerapan Model Pembelajaran STM untuk Meningkatkan Keterampilan Berpikir Kreatif dan Rasa Ingin Tahu Siswa Kelas IV SD Negeri Pesanggrahan 02
Authors: Makhvudah Cholis , Eka Karma Iswasta , Bramasta Dhi 
Published: February 2021

Penelitian ini bertujuan untuk meningkatkan keterampilan berpikir kreatif dan rasa ingin tahu siswa melalui model pembelajaran Sains Teknologi Masyarakat (STM) pada tema 8 Daerah Tempat Tinggalku di kelas IV SD Negeri Pesanggrahan 02. Jenis penelitian ini adalah penelitian tindakan kelas model Kemmis dan MC Taggart yang dilaksanakan dalam satu siklus. Penelitian ini dilaksanakan pada semester II tahun ajaran 2019/2020 pada bulan Maret. Subjek yang digunakan siswa kelas IV SD Negeri Pesanggrahan 02 yang berjumlah 22 siswa yang terdiri dari 17 siswa laki-laki dan 5 siswa perempuan. Alat pengumpulan data menggunakan lembar evaluasi keterampilan berpikir kreatif, lembar observasi aktivitas guru, lembar observasi aktivitas siswa, lembar observasi rasa ingin tahu dan lembar angket sikap rasa ingin tahu siswa. Hasil penelitian menunjukkan adanya keterampilan berpikir kreatif pada siswa dari lembar tes keterampilan berpikir kreatif pada siklus I yaitu 69,32% dengan kriteria baik. Hasil lembar evaluasi sikap rasa ingin tahu siswa dari nilai rata-rata siswa pada siklus I yaitu 59,66% dengan kriteria cukup baik. Kesimpulan bahwa melalui model pembelajaran Sains Teknologi Masyarakat (STM ) menunjukan adanya peningkatan keterampilan berpikir kreatif dan rasa ingin tahu siswa pada tema 8 Daerah Tempat Tinggalku di kelas IV SD Negeri Pesanggrahan 02.
CALCULUL CÂMPULUI ELECTRIC ASOCIAT UNUI CUPLOR INDUCTIV DESTINAT TRANSFERULUI DE PUTERE WIRELESS
Authors: TUDORACHE Tiberiu , MARINESCU Andrei 
Published: February 2021

Contactless or wireless power transmission has become a widespread disruptive technology. Although known for more than 100 years, it is the result of the unprecedented development of microelectronics and power electronics in recent decades. Numerous technical solutions for near-field energy transmission at different power and frequency levels are currently established: capacitive electric field transmission (CPT), inductive magnetic field transmission (IPT), multi-coil transmission and simultaneous transmission via electric field and magnetic field as a combination of the first two. The materialization of the contactless transmission is achieved in theory and practice through different types of contactless coupling circuits, generically called "contactless couplers". The inductive coupler can be considered as an electrical transformer in air or with open magnetic circuit in which the primary (Tx) and the secondary winding (Rx) can occupy different positions from each other depending on the application [1]. It is considered a representative element for WPT (Wireless Power Transfer) systems currently used from transferred powers of several watts to tens or hundreds of kilo-watts. To increase the transfer efficiency, the coupler works at high frequencies, of the order of kHz or MHz and in some cases has planar windings, of different shapes, made of litz wire and usually has magnetic flux concentrators [2]. Any inductive coupler is integrated into a complex transmission system, consisting of many other components [3].
In addition to the electromagnetic calculation widely presented in other works, open magnetic circuit construction produces electric and magnetic scattering fields that have a negative effect on both electrical and electronic equipment in the vicinity and on human health if the exposure exceeds certain thresholds. These thresholds are indicated by international standards and requirements [4-5] achieved by applying the precautionary principle [6] so that they can be reviewed periodically and are not mandatory unless they are taken over in national law.
In this paper we analyze by the finite element method, in approximate 2D, the electric field produced by an inductive coupler in various simplified construction variants and calculate certain related quantities of practical importance such as: electric field distribution in the field of calculation, electric field strength in the vicinity of the inductive coupler, equipotential lines, reactive power, equivalent capacities.
PENGARUH PERAN DAN INOVASI TERHADAP KINERJA KARYAWAN DI PTPN IV UNIT KEBUN MARIHAT
Authors: Ummi Mardiah  , Simatupang Pandapotan 
Published: February 2021

Pengaruh Peran dan Inovasi Terhadap Kinerja Karyawan di PTPN IV Unit Kebun Marihat. Penelitian ini bertujuan untuk mengetahui apakah peran dan inovasi berpengaruh terhadap kinerja karyawan di PTPN IV Unit kebun Marihat, Karyawan yang dimaksud disini ialah mandor yang bertugas di PTPN IV Unit Kebun marihat.
Hipotesis pada penelitian ini adalah peran dan inovasi berpengaruh terhadap kinerja karyawan di PTPN IV Unit kebun marihat. Responden pada penelitian ini adalah seluruh populasi yang berjumlah 36 orang, yaitu Mandor yang bertugas di PTPN IV Unit kebun Marihat tersebut. Teknik analisa data yang digunakan adalah regressi berganda dengan persamaan Y = a + bX1 + bx2 dan dari hasil analisa data diketahui Y=0,493 + 0,624X1 + 0,352X2, Dari uji hipotesis secara parsial bahwa peran dan inovasi berpengaruh terhadap kinerja karyawan di PTPN IV Unit kebun Marihat.Dengan demikian hipotesis diterima
ANALISIS KELAYAKAN BISNIS CAFE PADA KHALIZTA COFFEE & RESTO KOTA PEMATANGSIANTAR
Authors: Pasaribu Lika , Liharman Saragih  
Published: February 2021

Studi kelayakan bisnis merupakan penelitian yang bertujuan untuk memutuskan apakah sebuah ide bisnis layak atau tidak. Cafe Khalizta Coffee & Resto Kota Pematangsiantar merupakan salah satu café yang baru berjalan selama 11 bulan, sehingga akan diuji apakah usaha tersebut telah layak berdasarkan aspek keuangan. Berdasarkan hasil analisis didapat bahwa aspek keuangan dikatakan layak, dengan nilai Payback Period (PP) 1 tahun 6 bulan 23 hari. Nilai Net Present Value (NPV) 1.186.386.674, nilai Profitability Index (PI) 2,68, nilai Internal Rate of Return (IRR) sebesar 101%, nilai Average Rate of Return (ARR) 108 % aspek keuangan dinyatakan layak dan dapat dilanjutkan