bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular Revascularization of Heavily Calcified Occlusion in Superior Mesenteric Artery using Transcollateral Approach
Authors: Horie Kazunori , Tanaka Akiko , Tada Norio 
Published: April 2021

Abstract
BACKGROUND: Mesenteric ischemia is often a manifestation of severe vascular disease involving the superior mesenteric artery (SMA). Endovascular revascularization is still challenging in a chronic total occlusion (CTO) of SMA.CASE PRESENTATION: An-73-year-old male was referred to our hospital because of a 2-year history of abdominal angina after each meal. Computed tomography (CT) images revealed a heavily calcified CTO in the ostium of SMA. Angiography did not show the collateral route suitable for transcollateral approach (TCA); however, the three-dimension CT detected pancreaticoduodenal arcade from the celiac artery to the occluded SMA. According to CT imaging, transcollateral wire crossing from the celiac artery was successful in the SMA-CTO. After pull-through of the guide wire, two balloon-expandable stents were deployed in the ostium of SMA. During 3 months after the stent implantation, the patient had no further episodes of abdominal angina on dual-anti-platelet therapyCONCLUSIONS: We demonstrated a case of SMA occlusion with heavy calcification treated with stent implantation using TCA guided by CT imaging.
Landmark-Centered Coding in Frontal Cortex Visual Responses
Authors: Schütz Adrian , Bharmaurisa Vishal , Yan Xiaogang , Wang Hongying , Bremmer Frank , Crawford Doug 
Published: April 2021

Abstract
Visual landmarks influence spatial cognition, navigation and goal-directed behavior, but their influence on visual coding for action is poorly understood. Here, we tested landmark influence on prefrontal visual responses by recording from 568 neurons in the frontal (FEF) and supplementary (SEF) eye fields of rhesus macaques. The response field (the area of visual space that modulates activity) for each neuron was tested in the presence
of a landmark placed at one of four configurations. We then fit the spatially tuned response fields against a spatial coordinate continuum between gaze- and landmark-centered models. When response fields were fit separately for each target-landmark configuration, the best fits shifted (mean 37% / 40%) toward landmark-centered coding in FEF / SEF respectively, confirming a configuration-dependent intermediate coding scheme. Overall, these data show that external landmarks influence prefrontal visual responses, possibly helping to stabilize movement goals in the presence of noisy internal egocentric signals.
Revisit the Effectiveness of Educational Kinesiology on Stress and Anxiety Amelioration in Kindergarteners With Special Needs: A Nonrandomized Trial
Authors: TAI Pui Lun Alan , LAU Kwok Wai Way 
Published: April 2021

Abstract
Although educational kinesiology is a popular intervention aims to improve brain functioning via physical movements, it lacks supporting scientific evidence. This study explores the effect of educational kinesiology on the changes in stress and anxiety markers in kindergarteners with special needs using psychometrics and biological measures. This open label non-randomized clinical trial was registered retrospectively in the Chinese Clinical Trial Registry (registration number: ChiCTR2000036305, url: http://www.chictr.org.cn/showproj.aspx?proj=58067, registration date: 22/08/2020). Thirty-seven kindergarteners with special needs (3.5-6.5 years old) were assigned to either the intervention group, which received one-hour educational kinesiology intervention weekly for a total of 10 weeks, or the wait-list control group. Scores of Parent-rated Preschool Anxiety Scale (PAS-TC), salivary cortisol and oxytocin levels were obtained pre- and post-intervention. After controlling baseline, the changes in oxytocin levels remained significantly different between groups (F1,35 = 5.590, p = 0.020, eta2 = 0.145), but not in cortisol levels (F1,35 = 0.364, p = 0.550, eta2 = 0.01). PAS-TC showed significant improvement in anxiety levels after the intervention in the intervention group (X2 = 4.367, p = 0.037, φ = 0.344, p = 0.037). Findings from both subjective and objective measures indicate a plausible anti-stress and anxiety effect in kindergarteners with special needs.
Comparative transcriptional analysis site-directed mutagenesis of transcriptional regulator SinR boosts productivity of menaquinone synthesis in Bacillus subtilis
Authors: Wu Jing , Li Wei , Zhao Shiguang , Qian Sen-he , Wang Zhou , Zhou Meng-jie , Hu Wen-song , Wang Jian , Hu Liu-xiu , Liu Yan , Xue Zheng-lian 
Published: April 2021

Abstract
Background: MK-7 is a highly valuable vitamin K2 produced by Bacillus subtilis. Biofilm forming caused by quorum sensing (QS) system was beneficial for MK-7 synthesis. However, the specific regulator in QS system which play the most significant role in biofilm formation and MK production have not been revealed at genetic level, and this limits the possibility of further increasing MK-7 production.Results: In this study, the influence of different mutants in QS system on biofilm formation and MK-7 production was investigated. The transcriptional regulator SinR was chosen finally because the complete knocking out of sinR (KO-SinR) maximized the biofilm biomass and increased the yield of MK-7. However, KO-SinR led to a large number of spore and wrinkle forming, which slow down even stop the MK-7 biosynthesis. Five SinR mutants (E97K, Y101L, W104K, R105S, SinRquad) were constructed by site-directed mutagenesis of four aromatic residues (Glu97, Tyr101, Trp104 and Arg105). Among these, SinRquad formed more wrinkly but smooth biofilm, and obtained the maximum MK-7 value (102.56±2.84 mg/L), which was ten times of the parent strain. Comparative transcriptional analysis showed that SinRquad promoted the synthesis of extracellular polymeric substances and inhibited the swimming motility of late-flagellar. In addition, SinRquad upregulated the expression level of ctaC-G operator and qcrA-C operator which encode the cytochromes. Upregulation of components in the oxidative respiratory chain of B. subtilis was due to the upregulation of NADH dehydrogenases. Most NADH dehydrogenases especially sdhA-C and glpD, increased 1.01-, 3.93-, 1.87-, 1.11- fold, respectively. The increase in expression level of NADH dehydrogenases indicated the ratio of NADH/NAD+ decreased and more electrons produced for the electron transport system (ETM). Wrinkly and smooth biofilm formed a network of interconnected channels with low resistance to liquid flow was beneficial to obtain a more stable state of electron transport chain, which facilitate the metabolic flux of four modules of MK-7 synthesis pathways.Conclusions: In this study, we report for the first time that SinRquad has significant effects on the MK-7 synthesis by forming wrinkly and smooth biofilm, upregulating the expression level of most NADH dehydrogenases, providing more stable state of the electron transport.
Ultrasonic Shear Device versus Monopolar Electric Cautery in Conservative Breast Surgery Following Neoadjuvant Chemotherapy: A Comparative Study
Authors: Khaled Islam , Saad Ihab , Soliman Hany , Faisal Mohammed 
Published: April 2021

Abstract
Background: Surgical devices are commonly used during breast-conservative surgery (BCS) to provide better hemostasis. Ultrasonic shear has recently gained momentum as an effective tool for intraoperative bleeding reduction. This comparative study was designed to determine the efficacy of Harmonic focus in reducing postoperative complications of BCS following neoadjuvant chemotherapy (CTH), in comparison to the conventional method using monopolar diathermy.Methods: We conducted a prospective, non-randomized, comparative, study on patients scheduled to undergo BCS with axillary dissection or sentinel lymph node biopsy after neoadjuvant CTH. Patients were recruited consecutively throughout the study period and were divided in an equal manner to undergo either monopolar electrocautery or Harmonic focus®.Results: Patients in the Harmonic Focus group had significantly shorter operative time than the monopolar electrocautery group (101.32 ± 27.3 versus 139.3 ± 31.9 minutes, respectively; p <0.001). Besides, the blood loss was significantly lower in the Harmonic Focus group (117.14 ± 35.6 versus 187 ± 49.8mL, respectively; p <0.001). Postoperatively, patients in the Harmonic Focus group had a significantly lower volume of chest wall drain (p <0.001) and shorter rime till drain removal (p <0.001). Likewise, patients in the Harmonic Focus group had a significantly lower volume of axillary drain and shorter rime till drain removal than monopolar electrocautery (p <0.001). The incidence of postoperative complications was comparable between both groups (p =0.128). Conclusions: In conclusion, the current study confirms the superiority of Harmonic Focus, compared to monopolar electrocautery, amongst patients receiving neoadjuvant CTH before BCS.
Burnout Among Physicians and Medical Interns: Comparing Time-periods of Coronavirus Disease Outbreak in Shiraz
Authors: Sarikhani Yaser , Khatami Kiana , Salehi-Marzijarani Mohammad , Estedlal AliReza , Sivandzadeh Gholam Reza , Kouhi Pariya , Shahabi Saeed , Zarei Leila , Heydari Seyed Taghi , Lankarani Kamran Bagheri 
Published: April 2021

Abstract
Background: Physician burnout is a serious issue associated with physician attrition, mental and physical problems, and medical errors. This study aimed to investigate prevalence of overall burnout among Interns-Residents and general physician (GPs)-Specialist during the COVID-19 pandemic in Iran.Methods: This cross-sectional study was conducted among 220 Interns-Residents and 212 GPs-Specialists in university affiliated hospitals and clinics in Shiraz, Iran. A random sampling method used to recruit the samples and the data gathered using a valid questionnaire. We used covariance analysis and multiple logistic regression to analyze the data.Results: Multiple logistic regression for GPs-Specialists showed that working in COVID-19 wards during June-July (OR = 13.93) was associated with increasing odds of overall burnout. However, older age was associated with decrease odds overall burnout (OR = 0.94). Multiple logistic regression for Interns-Residents revealed that age (OR = 1.24) and being single (OR = 1.66) were positively associated with overall burnout.Conclusions: The present finding could remind policy makers the importance of burnout issue among physicians during the pandemics and could persuade them for taking appropriate action in order to prevent this phenomenon. It is suggested that focusing on strategies such as improving organizational resilience, improvement of healthcare working environment, and development of coping skills among physicians could be helpful in this regard.
Influence of pH on the DSSC Performance of Template Assisted SnO2 Nanostructures
Authors: R vasanthapriya , N NEELAKANDESWARI , Uthayarani K. , Chitra M. 
Published: April 2021

Abstract
This paper reports the performance of alizarin based SnO2 dye-sensitized solar cells. A novel template assisted method has been applied for the preparation of tin oxide nanoparticles. For the first time, onion (Allium cepa) was used as a template for the synthesis of tin oxide nanostructures at different pH values. Tin oxide nanostructures were used for the photoanode preparation. A sandwich cell was prepared by using the dye soaked SnO2 film as a photoanode and platinum as a counter electrode. The structural, morphological and optical properties of the nanoparticles were studied using powder X-ray diffraction (XRD), Scanning Electron microscope (SEM), Photoluminescence (PL), Attenuated Total Reflectance (ATR) spectra and UV-visible spectroscopic techniques. Current-voltage (I-V) characteristics have been measured using electrochemical workstation under the presence of solar illumination. Characteristic parameters of the fabricated cell were determined on the basis of the measured I-V curves.
Presepsin as a Biomarker for Risk Stratification and Prognosis of Acute Cholangitis:A Single Center Prospective Cohort Study
Authors: Zhang Hanyu , Lu Zhaoqing , Wang Guoxing , Wu Di , Ge Xu , Xie Miaorong , Li Chunsheng 
Published: April 2021

Abstract
Background: Presepsin is currently a promising biomarker for the early diagnosis and prognosis of acute bacterial infection. Acute cholangitis is caused by bacterial infection and has high morbidity and mortality. The study engaged to assess the grading and prognostic value of presepsin in patients with acute cholangitis. Methods: This study enrolled patients with acute cholangitis in the emergency department from May 1, 2019 to December 20, 2020. The patients were evaluated for severity by the 2018 Tokyo Guidelines for Acute Cholangitis. Patients’ baseline features and routine clinical data were collected. On admission, presepsin, procalcitonin (PCT) and systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores were determined; and blood cultures were performed. IBM SPSS software (version 22.0) was used. The comparation of values was performed by Pearson chi-square test or Fisher's exact test or Mann-Whitney U test. The area under the receiver operating characteristic curve (AUC), multivariate logistic regression, and correlation analysis were used to analyze this importance of determining the presepsin levels on admission for acute cholangitis. Results: In total, 330 patients, including 109, 101, and 120 patients classified as having mild, moderate, and severe cholangitis, respectively, were examined. The AUCs of presepsin were 0.713 in predicting severe acute cholangitis, better than those of white blood cell (WBC 0.411), C-reactive protein (CRP 0.615), PCT 0.608, and total bilirubin (T-Bil 0.441) (P<0.05). The AUC of presepsin in predicting 28-day mortality was higher than that of WBC, CRP, PCT, and T-Bil. The presepsin level in the positive blood culture group was higher than that in the negative blood culture group (P=0.000). The P values for correlations of presepsin with SIRS and SOFA scores were 0.002 and 0.000, respectively. Conclusions: Presepsin levels on admission were correlated with SIRS and SOFA scores. Presepsin may predict positive blood culture and 28-day mortality in patients with acute cholangitis, and it is superior to WBC, CRP, PCT, and T-Bil in the risk stratification and prognostic assessment of severe cholangitis. Trial registration: Ethical code of this study is 2018-P2-063-01 and acquired on May, 22, 2018.
Energy Saving Diagnosis Model of Petrochemical Plant Based on Intelligent Curvelet Support Vector Machine
Authors: zhao bin , qin dou , Gao Diankui , xu lizhi 
Published: April 2021

Abstract
The energy and resources saving has become a major task of petrochemical enterprises, it is necessary to construct the energy saving diagnostic system for understand the real time operation information of petrochemical plant and provide theoretical basis for taking energy saving measures. The energy saving diagnosis process of petrochemical plant based on twin Curvelet support vector machine optimized by hybrid glowworm swarm algorithm is designed. The Curvelet kernel function is constructed based on curvelet transform to establish theory model of twin curvelet support vector machine. In order to improve the prediction precision of the twin curvelet support vector machine, the hybrid glowworm swarm optimization algorithm is constructed based on simulated annealing simulation to optimize the parameters of the twin Curvelet support vector machine. Finally, a petrochemical plant is used as research object to carry out diagnosis simulation analysis, and results showed that the proposed prediction model can effectively improve diagnostic effectiveness of the energy saving effect of petrochemical plant.
Improved Clinical Outcomes of Outpatient Enhanced Recovery Hip and Knee Replacements in Comparison to Standard Inpatient Procedures: A Study of Patients Who Experienced Both
Authors: Hardy Alexandre , Courgeon Margaux , Pellei Karina , Desmeules François , Loubert Christian , Vendittoli Pascal-André 
Published: April 2021

Abstract
BACKGROUND: The benefits of combining enhanced recovery after surgery (ERAS) interventions with an outpatient program for total hip/knee arthroplasty (THA/TKA) are uncertain. The primary objective was to compare adverse event rate and secondly to compare pain management, functional recovery, PROMs and satisfaction in patients who experienced both an ERAS-outpatient protocol and standard-inpatient care.METHODS: We conducted an ambidirectional single subject cohort study on 48 consecutive patients who experienced both a standard-inpatient and an ERAS-outpatient THA/TKA (contralaterally). We compared complications according to Clavien-Dindo scale and Comprehensive Complications Index (CCI), and unplanned episodes of care. Postoperative pain assessed with a numeric rating scale, opioid consumption in morphine milligram equivalents, functional recovery, patient-reported outcome measures (WOMAC, KOOS, HOOS, Forgotten Joint Score and Patient Joint Perception) and patients’ satisfaction were also evaluated.RESULTS: Following the ERAS-outpatient surgery, complication rates were reduced by more than 50% (2.1 vs 4.4, p<0.001), CCI was significantly lower (12.3 vs 19.1, p<0.001), and similar unplanned episodes of care were observed (p>0.999). In the first 8 postoperative hours, perceived pain was similar (p>0.805) while opioid consumption was significantly reduced (9.3 vs 26.5, p<0.001). Patients walked, climbed stairs, showered, performed activities of daily living, practised sports, went back to work sooner (p<0.001), but PROMs were similar between groups at the last follow-up (p> 0.188). Patients were more satisfied of the ERAS-outpatient pathway and recommended it significantly more (p <0.002). CONCLUSION: Compared to the conventional inpatient care, our ERAS-outpatient protocol proved to be safer, enable faster functional recovery, and improve patients’ satisfaction which highlight the importance of following ERAS principles when implementing an outpatient THA/TKA program.
The structure of black holes
Authors: Devadithya Nalin de Silva 
Published: April 2021

Abstract
Contrary to the general belief that a black hole has only an event horizon and a singularity it is shown that it has a structure. The structure of a black hole is worked out using Schwarzschild interior solution. It is shown that there is an attraction towards the centre of the distribution when the radius r of the sphere is greater than 9m /4 where m= GM/c2 , M being the mass of the distribution of matter. When the radius is between 9m /4 and 2m the attraction is replaced by a repulsion first at the centre and then in a core gradually increasing in radius up to 2m. The matter is repelled towards the surface ending up with a spherical shell of radius 2m and of infinite density, forming a black hole.
Incidence of cerebral venous sinus thrombosis in adults in Germany – a retrospective study using health claims data
Authors: Jacob Josephine , Klamroth Robert , Ploner Tina , Harder Thomas , Koch Judith , Wichmann Ole , Walker Jochen 
Published: April 2021

Abstract
In March 2021 several cases of cerebral venous sinus thrombosis (CVST) accompanied by thrombocytopenia were reported that occurred within two weeks after immunization with a viral vector-based COVID-19 vaccine. This study aimed to assess the background incidence of CVST and CVST with concurrent thrombocytopenia in adults using anonymized claims data from 2015-2019 in Germany. The average annual CVST incidence was 1.9 per 100,000 individuals (95%-CI 1.4-2.3). It was higher in women aged 18 to 59 years as compared to same-aged men. In contrast to the currently reported immunization-related cases, CVST was rarely associated with concurrent thrombocytopenia or death.
5 THz bandwidth photonic radio frequency spectrum analyzer based on a CMOS-compatible high-index doped silica waveguide
Authors: LI YUHUA , KANG ZHE , ZHU KUN , AI SHIQI , WANG XIANG , DAVIDSON ROY R. , WU YAN , MORANDOTTI ROBERTO , LITTLE BRENT E. , Moss David , CHU SAI TAK 
Published: April 2021

Abstract
We report an all-optical radio-frequency (RF) spectrum analyzer with a bandwidth greater than 5 terahertz (THz), based on a 50-cm long spiral waveguide in a CMOS-compatible high-index doped silica platform. By carefully mapping out the dispersion profile of the waveguides for different thicknesses, we identify the optimal design to achieve near zero dispersion in the C-band. To demonstrate the capability of the RF spectrum analyzer, we measure the optical output of a femtosecond fiber laser with an ultrafast optical RF spectrum in the terahertz regime.
Cow dung and tea waste amendments enhance the biotransformation of textile mill sludge into vermicomposts using Eisenia fetida
Authors: Badhwar Vinay Kumar , Singh Charanjit 
Published: April 2021

Abstract
Vermicomposting of textile mill sludge (TMS) with cow dung (CD) and tea waste (TW) as amendments was done in seven different combinations using Eisenia fetida for 90 days. Results revealed that pH decreased from 7.68–8.63 to 7.09–7.59. TOC content and C/N ratio reductions were in range of 15.71–20.08% and 39.33–50.05% respectively (P < 0.05). The macronutrients in the form of TN, TP and TK increased 0.38–0.64 folds, 1.07–2.27 folds and 0.56–1.98 folds respectively after the end of bioconversion process (P < 0.05), among increases in ash content and EC. The biomass and cocoon production of E.fetida increased significantly (P < 0.05), while increasing mortality rate of earthworms was observed in treatments containing 50% or more TMS content. The bacterial population beneficial for degradation of organic matter increased significantly over initial substrates (P < 0.05). Increased humification index in the end product indicated better maturity of vermicompost as observed in treatments containing higher proportions of amendments. The addition of amendments favored earthworm activity which significantly decreased the heavy metal concentration (Fe, Cu, Pb, Zn) in the end product. The study concluded that sustainable utilization of TMS could be achieved for the cleaner and enriched vermicompost production by addition of amendments CD and TW in proportions of 50% and above.
Research of Forecasting Information Time Delays with Nenural Network in Telecontrol System
Authors: Shuping Xu , Jinfe Wu , Xiaohui Su , Xiaodun Xiong 
Published: April 2021

Abstract
Aiming at the issues of random delay and delay uncertainty in both the before channel and feedback channel for network control system, the root causes of random delay influence closed-loop control system by case is analysis, and the predictive control method based on neural network to solve the feasibility of existence network random delay in control system closed-loop control has provided. Simulation results show that the method can reflect and predict the delay characteristics of between measurement data represents the network path, and can effectively substitute for the actual network in the design of closed-loop control system based on Internet to research; the method used fast and accurate can be used for online learning network model and forecast the network delay value, provides a new way to remote closed-loop control based on Internet.