bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of CEO regulatory focus on changes to investments in R&D
Authors: Scoresby Richard B. , Withers Michael C. , Ireland R. Duane 
Published: July 2021

AbstractResearch and development (R&D) is a key contributor to organizations’ pursuit of innovation. In turn, CEOs can influence important decisions related to changes in R&D spending—the kind of spending with the potential to lead to innovation. We seek to understand the motivation and conditions under which CEOs may influence R&D spending changes. Drawing on regulatory focus theory, this study investigates how CEO motivation affects changes in firm R&D spending. We explore the effect of CEO promotion and prevention foci on yearly R&D increase. We use a panel dataset of 688 S&P 1500 firms to test our hypotheses. Our findings suggest a negative relationship between CEO prevention focus and R&D increase, while CEO promotion focus produces no meaningful effect. We further test CEO compensation as a moderating mechanism, testing both incentive and fixed CEO compensation. We find that incentive compensation negatively moderates the relationship between CEO promotion focus and R&D increase, and positively moderates the relationship between CEO prevention focus and R&D increase. Additionally, CEO fixed income negatively moderates the relationship between CEO prevention focus and R&D increase. Based on these results we discuss theoretical implications of our findings, including differing effects of CEO regulatory focus on firm risk‐taking behavior and how compensation packages may alter those effects. We further discuss the practical necessity for boards of directors to understand both the R&D goals of an organization and the individual motivational orientation of CEOs when crafting compensation packages.
Effect of total replacement of fish oil with tallow and emulsifier in diet on growth, feed utilization, and immunity of olive flounder (Paralichthys olivaceus)
Authors: Medagoda Nalin , Kim Min‐Gi , Gunathilaka Buddhi E. , Park Seung‐Hwan , Lee Kyeong‐Jun 
Published: July 2021

AbstractThe supplementary effects of an emulsifier mixture (polyoxyethylene (20) sorbitan monolaurate and distilled monoglycerides) were investigated on feed utilization, growth performance, and immunity of olive flounder, Paralichthys olivaceus, replacing fish oil with beef tallow. A fish oil containing diet was considered as positive control (PC) and a diet containing beef tallow instead of fish oil was considered as negative control (TW). Two other diets (EM01 and EM02) were prepared by adding 0.01 and 0.02% of the emulsifier into the TW diet. After 8 weeks of a feeding trial, growth performance and feed utilization were significantly higher in fish fed EM01, EM02, or PC diets compared to those fed the TW diet. Dry matter digestibility was higher in EM01 and EM02 diets than the TW diet and comparable to PC diet. Lipid digestibility was significantly higher in PC diet compared to TW diet. Liver EPA and DHA levels were lower, and oleic acid level was higher in fish fed diets containing tallow compared to PC group. Significantly increased aspartate aminotransferase and triglyceride levels were observed in TW group. Dietary supplemented emulsifier restored the reduced performance of olive flounder fed diets containing tallow instead of fish oil. However, the optimum inclusion level of the emulsifier should be elucidated in future studies.
Growth, red blood cells, and gill alterations of red pacu (Piaractus brachypomus) fingerlings by chronic exposure to different total suspended solids in biofloc
Authors: Angeles‐Escobar Beatriz Elena , da Silva Suzianny Maria Bezerra Cabral , Severi William 
Published: July 2021

AbstractChronic exposure to high biofloc total suspended solids (TSS) could affect growth, red blood cells, and generate gill alterations in fish. Red pacu, Piaractus brachypomus, fry (2.7 ± 0.5 g weight) were exposed to different biofloc TSS concentrations with low (T1: 200–300), and medium (T2: 400–600 mg/L) levels and compared to a treatment control (TC) without solids during a 45‐day period in 50 L experimental units (in quadruplicate). Water quality, productive parameters, red blood cell values, and gill histopathological alteration index (HAI) were assessed. Red pacu reached higher final biomass (11.34 ± 0.73 kg/m3), better growth (DWG = 0.30 ± 0.03 g/day) and food conversion rate (1.05 ± 0.02) in TC than in biofloc treatments (p < .05). T2 had higher RBC count, and lower hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration (p < .05) than T1 and TC. The histological sections of TC gills showed monogenean parasites in low quantity; thus, the HAI value was similar among treatments and corresponded to low to medium gill damage. Growth, red blood cell values, and gill morphology of red pacu fingerlings were affected by moderate (400–600 mg/L) chronic exposure to TSS concentration in biofloc.
IIE irons: Origin, relationship to ordinary chondrites, and evidence for siderophile‐element fractionations caused by chondrule formation
Authors: Rubin Alan E. 
Published: July 2021

AbstractIIE irons were derived from chondritic precursors that were the most reduced ordinary chondrites. The bulk chemical (e.g., Ir/Ni, Ir/Au, Au/Ni, Co/Ni) and bulk isotopic (i.e., Δ17O and δ74/70Ge) compositions of IIE irons lie along extensions of LL‐L‐H trends. Chondrule‐bearing silicate clasts in IIE irons have mineralogical and petrological characteristics that extend LL‐L‐H trends; these clasts have higher modal metallic Fe‐Ni and lower values for olivine Fa, low‐Ca‐pyroxene Fs, kamacite Co, and mean chondrule diameter. IIE irons are modeled as agglomerating before H‐L‐LL chondrites; they acquired more 26Al and reached the Fe,Ni‐FeS eutectic temperature (~940 °C). An FeS‐rich metallic melt separated from unmelted silicate and drained to the core, eventually generating a dynamo. Most IIE metal remained within the crust/mantle region alongside recrystallized chondritic clasts. Alkali‐rich IIE silicate inclusions formed from late‐stage impacts via preferential melting of plagioclase. Some separation of K from Na occurred during vapor transport. Because most type I chondrules formed before most type II chondrules, the (type I)/(type II) modal ratio decreased from IIE to H to L to LL during agglomeration. Earlier‐formed chondrules acquired higher abundances of refractory metal nuggets within CAI‐fragment precursors, accounting for systematic changes in bulk OC of refractory/common siderophile and refractory/volatile siderophile ratios (IIE>H>L>LL). Because more Au and Co than Ni were retained in silicates, loss of metal globules from spinning partly molten type I chondrules caused systematic whole‐rock decreases in Au/Ni and Co/Ni from IIE through LL. Expelled globules had different nebular aerodynamic properties than chondrules and drifted away (accounting, in part, for the metal/silicate fractionation).
Organic matter in carbonaceous chondrite lithologies of Almahata Sitta: Incorporation of previously unsampled carbonaceous chondrite lithologies into ureilitic regolith
Authors: Kebukawa Yoko , Zolensky Michael. E. , Goodrich Cyrena A. , Ito Motoo , Ogawa Nanako O. , Takano Yoshinori , Ohkouchi Naohiko , Kiryu Kento , Igisu Motoko , Shibuya Takazo , Marcus Matthew A. , Ohigashi Takuji , Martinez James , Kodama Yu , Shaddad Muawia H. , Jenniskens Peter 
Published: July 2021

AbstractThe Almahata Sitta (AhS) meteorite is a unique polymict ureilite. Recently, carbonaceous chondritic lithologies were identified in AhS. Organic matter (OM) is ubiquitously found in primitive carbonaceous chondrites. The molecular and isotopic characteristics of this OM reflect its origin and parent body processes, and are particularly sensitive to heating. The C1 lithologies AhS 671 and AhS 91A were investigated, focusing mainly on the OM. We found that the OM in these lithologies is unique and contains primitive isotopic signatures, but experienced slight heating possibly by short‐term heating event(s). These characteristics support the idea that one or more carbonaceous chondritic bodies were incorporated into the ureilitic parent body. The uniqueness of the OM in the AhS samples implies that there were large variations in primitive carbonaceous chondritic materials in the solar system other than known primitive carbonaceous chondrite groups such as CI, CM, and CR chondrites.
Cross‐instrument feasibility, validity, and reproducibility of wireless heart rate monitors: Novel opportunities for extended daily life monitoring
Authors: Kunkels Yoram K. , van Roon Arie M. , Wichers Marieke , Riese Harriëtte 
Published: July 2021

AbstractWired ambulatory monitoring of the electrocardiogram (ECG) is an established method used by researchers and clinicians. Recently, a new generation of wireless, compact, and relatively inexpensive heart rate monitors have become available. However, before these monitors can be used in scientific research and clinical practice, their feasibility, validity, and reproducibility characteristics have to be investigated. Therefore, we tested how two wireless heart rate monitors (i.e., the Ithlete photoplethysmography (PPG) finger sensor and the Cortrium C3 ECG monitor perform against an established wired reference method (the VU‐AMS ambulatory ECG monitor). Monitors were tested on cross‐instrument and test‐retest reproducibility in a controlled laboratory setting, while feasibility was evaluated in protocolled ambulatory settings at home. We found that the Cortrium and the Ithlete monitors showed acceptable agreement with the VU‐AMS reference in laboratory setting. In ambulatory settings, assessments were feasible with both wireless devices although more valid data were obtained with the Cortrium than with the Ithlete. We conclude that both monitors have their merits under controlled laboratory settings where motion artefacts are minimized and stationarity of the ECG signal is optimized by design. These findings are promising for long‐term ambulatory ECG measurements, although more research is needed to test whether the wireless devices’ feasibility, validity, and reproducibility characteristics also hold in unprotocolled daily life settings with natural variations in posture and activities.
Evidence for the association between physiological and emotional states in adolescents and young adults without psychopathology under ecologically valid conditions
Authors: Zenker Monique , Venz John , Koenig Julian , Voss Catharina , Beesdo‐Baum Katja , Pieper Lars 
Published: July 2021

AbstractWell‐powered studies on the physiological concomitants underlying affect and its regulation during emerging adulthood are warranted to provide novel insight into mental health. The association between autonomic nervous system activity and emotional states occurring under natural conditions in daily life was investigated in individuals (N = 549, age 14–21, females 45.6%) without any lifetime mental disorder from an epidemiological cohort study in Germany. Using ecological momentary assessment, mood and optimism/pessimism were assessed over 4 days simultaneously with continuous heart rate monitoring. Lower vagal activity was found in mood states accompanied by high arousal (wakefulness, mania) and greater vagal activity in mood states with low arousal (calmness, pessimism). Findings illustrate important associations between autonomic nervous system activity and mood in youth under ecologically valid conditions. Vagal activity presents a prominent pathway by which mood may influence physiological function or vice versa. In contrast to commonly performed laboratory assessments, the ambulatory assessment in participants' daily life allows an application of the results to the field.
Reducing the Number of Experiments Required for Modelling the Hydrocracking Process with Kriging Through Bayesian Transfer Learning
Authors: Iapteff Loïc , Jacques Julien , Rolland Matthieu , Celse Benoit 
Published: July 2021

Abstract
The objective is to improve the learning of a regression model of the hydrocracking process using a reduced number of observations. When a new catalyst is used for the hydrocracking process, a new model must be fitted. Generating new data is expensive and therefore it is advantageous to limit the amount of new data generation. Our idea is to use a second data set of measurements made on a process using an old catalyst. This second data set is large enough to fit performing models for the old catalyst. In this work, we use the knowledge from this old catalyst to learn a model on the new catalyst. This task is a transfer learning task. We show that the results are greatly improved with a Bayesian approach to transfer linear model and kriging model.
Globalization, Productivity Performance, and the Transformation of the Production Process*
Authors: Baldwin John , Yan Beiling 
Published: July 2021

AbstractIn this paper, we examine whether a firm's decision to export and its subsequent performance are related to its prior global connections. By tracking Canadian manufacturing firms over an eight‐year period between 2002 and 2010, we find that firms with prior global connections (such as importing) are more likely to subsequently become exporters. Productivity and skill intensity grow faster in this group in the short and longer run than those with no global connections. The growth advantage is affected by movements in the exchange rate. In general, growth rates in productivity and investments in physical, human, and intangible innovation R&D are greater for firms with more international connections.
Cytomegalovirus‐associated pseudomembranous colitis in a kidney transplant recipient
Authors: Chua Yi Yi , Ho Quan Yao , Ngo Nye Thane , Krishnamoorthy Thinesh Lee , Thangaraju Sobhana , Kee Terence , Wong Hei Man 
Published: July 2021

AbstractPseudomembranous colitis (PMC) is classically associated with Clostridium difficile infection. We report a rare case of cytomegalovirus (CMV)‐associated PMC in a 52‐year‐old female patient who had undergone kidney transplantation more than 20 years ago and was on low dose prednisolone and ciclosporin. She presented with an acute history of fever, lethargy, vomiting and diarrhoea on admission. Computed tomography of the abdomen showed extensive colitis, and colonoscopy revealed extensive pseudomembrane formation. Multiple tests for Clostridium difficile and other common microbiological causes of colitis were negative. CMV DNAemia and colonic biopsies confirmed the diagnosis of CMV colitis. The patient responded to prompt CMV treatment, as demonstrated by clinical, endoscopic, and histological response. While CMV is a common pathogen in the solid organ transplant population that is familiar to most transplant physicians, it may present atypically as PMC. Here, we review the literature on CMV‐associated PMC and its relevance to solid organ transplant recipients. To our knowledge, this is the first reported case of CMV‐associated PMC in a kidney transplant recipient.
Commitment behaviour in the World Trade Organization's Trade Facilitation Agreement
Authors: Hillberry Russell , Zurita Carlos 
Published: July 2021

AbstractWe use a new database of commitments made during the process of ratifying the Trade Facilitation Agreement (TFA) to study variation in countries’ commitment behaviour. The TFA is a novel World Trade Organization agreement because it allows developing countries to select commitments from a menu of best practices in trade facilitation, rather than to consent, or not, to a comprehensive package of negotiated commitments. The operation of this á la carte approach to concluding trade agreements is worthy of study in its own right, but the commitment data also offer a high‐level description of progress in an international effort to improve border management procedures around the globe. Our study uses data on TFA commitments to describe progress across subcomponents of the agreement. A regression model shows that the number of Type A trade facilitation commitments that a country made in the TFA ratification process depends on its level of development, population size, ability to control corruption and foreign aid received to support trade facilitation. We use multidimensional scaling techniques to study differences in the content of national commitment bundles. This approach demonstrates that variation in the content of countries’ commitments is closely tied to the number of commitments made.
Trypanosoma cruzi infection in triatomines (Hemiptera: Reduviidae) from rural areas of the state of Pará, Brazil
Authors: Barros Flávia de Nazaré Leite , Vieira Juliana dos Santos Cruz , Sampaio Júnior Francisco Dantas , Lima Jaqueline dos Santos , Nobre Adriana Vasconcelos , Barrozo Pedro Henrique Marques , Paiva Jessica Rodrigues de , Cavalcante Gustavo Góes , Scofield Alessandra 
Published: July 2021

AbstractThe present study aimed to identify the triatomine species and evaluate Trypanosoma cruzi infection in insects captured in endemic areas of Pará State, Brazil. Triatomines were captured in nine rural communities in the municipality of São Domingos do Capim in August, September and December 2014 using active searches and Malaise and Noireau traps. Additionally, from 2014 to 2018, residents and community health agents submitted captured triatomines to the study team. The analysis of T. cruzi infection in the insects was performed by direct parasitological examination and nested‐PCR. A total of 225 triatomines were captured and identified: Rhodnius robustus (n = 111), Rhodnius pictipes (n = 54), Panstrongylus geniculatus (n = 44), Eratyrus mucronatus (n = 11), Panstrongylus lignarius (n = 4), and Panstrongylus rufotuberculatus (n = 1). Direct parasitological examination was performed in 27 living triatomines R. robustus (n = 14), P. geniculatus (n = 7) and R. pictipes (n = 6) and metacyclic trypomastigote forms similar to those of T. cruzi were observed in 66.6% (18/27) samples. Of 174 samples analysed by nested‐PCR, 81.6% were positive for T. cruzi DNA: R. robustus (84.7%; 72/85), R. pictipes (84.1%; 37/44), P. geniculatus (69.4%; 25/36), P. lignarius (100%; 4/4), E. mucronatus (75%; 3/4) and P. rufotuberculatus (100%; 1/1). R. robustus, R. pictipes and P. geniculatus were the main vectors of T. cruzi in the studied areas; however, the detection of infections in P. lignarius, E. mucronatus and P. rufotuberculatus indicated that these species can also act as potential vectors of T. cruzi in the study areas.
Fibrillin-1gene mutations in a Chinese cohort with congenital ectopia lentis: spectrum and genotype–phenotype analysis
Authors: Chen Zexu , Chen Tianhui , Zhang Min , Chen Jiahui , Deng Michael , Zheng Jialei , Lan Li-Na , Jiang Yongxiang 
Published: July 2021

AimsTo identify the mutation spectrum and genotype–phenotype correlations offibrillin-1(FBN1) mutations in a Chinese cohort with congenital ectopia lentis (EL).MethodsPatients clinically suspected of congenital zonulopathy were screened using panel-based next-generation sequencing followed by multiplex ligation-dependent probe amplification. All the probands were subjected to thorough ocular examinations. Molecular and clinical data were integrated in pursuit of genotype–phenotype correlation.ResultsA total of 131 probands ofFBN1mutations from unrelated families were recruited. Around 65% of the probands were children younger than 9 years old. Overall, 110 distinctFBN1mutations were identified, including 39 novel ones. The most at-risk regions were exons 13, 2, 6, 15, 24 and 33 in descending order of mutation frequency. The most prevalent mutation was c.184C>T (seven, 5.34%) in the coding sequence and c.5788+5G>A (three, 2.29%) in introns. Missense mutations were the most frequent type (103, 78.63%); half of which were distributed in the N-terminal regions (53, 51.46%). The majority of missense mutations were detected in one of the calcium-binding epidermal growth factor-like domains (62, 60.19%), and 39 (62.90%) of them were substitutions of conserved cysteine residues. Microspherophakia (MSP) was found in 15 patients (11.45%). Mutations in the middle region (exons 22–42), especially exon 26, had higher risks of combined MSP (OR, 5.51 (95% CI 1.364 to 22.274), p=0.017).ConclusionsThis study extended the knowledge of theFBN1mutation spectrum and provided novel insights into its clinical correlation regarding EL and MSP in the Chinese population.
MRI signs helpful in the differentiation of patients with anterior ischaemic optic neuropathy and optic neuritis
Authors: Petroulia Valentina Daphne , Brügger Dominik , Hoepner Robert , Vicini Rino , Winklehner Anna , Abegg Mathias , Wagner Franca 
Published: July 2021

Background/AimsThe aim of this study was to identify specific MRI characteristics of anterior ischaemic optic neuropathy (AION) and optic neuritis (ON) that would aid in the differentiation between these two diagnoses.MethodsWe retrospectively analysed a consecutive case series including all patients with an MRI study of brain and orbit and the clinical diagnosis of either ON or AION. We examined the scans for restricted diffusion of the optic nerve, optic sheath diameter, enhancement and location of enhancement of the optic nerve and distribution of the white matter lesions.ResultsFifty patients met the inclusion criteria. We found an accuracy of 0.98 for the discrimination between AION and ON based solely on parameters extracted from MRI data. Dominance analysis to determine the most influential parameters showed that the enhancement pattern of the optic nerve and distribution of the white matter lesions had the biggest impact on the classification and led to a discrimination accuracy of 0.9 when used alone.ConclusionIn patients with an inconclusive clinical diagnosis, optic nerve enhancement pattern and distribution of white matter lesions can aid in the diagnosis and differentiation between AION and ON. Diffusion-weighted imaging did not add significant information to the diagnosis or help to differentiate between the two conditions.
Living with Psychosis without Mental Health Services: A Narrative Interview Study
Authors: McGranahan Rose , Jakaite Zivile , Edwards Alice , Rennick-Egglestone Stefan , Slade Mike , Priebe Stefan 
Published: July 2021

ObjectivesLittle research has looked at how people who do not use mental health services experience psychosis. Thus, the present study aimed to explore the experiences and views of people with psychosis who have neither sought nor received support from mental health services for at least 5 years.DesignA narrative interview study. Thematic analysis was used to analyse the data.SettingEngland.ParticipantsTwenty-eight participants with self-defined psychotic experiences were asked to provide a free narrative about their experiences.ResultsFive themes were identified: (1) Perceiving psychosis as positive; (2) Making sense of psychotic experiences as a more active psychological process to find explanations and meaning; (3) Finding sources of strength, mainly in relationships and the environment, but outside of services; (4) Negative past experiences of mental health services, leading to disengagement and (5) Positive past experiences with individual clinicians, as an appreciation of individuals despite negative views of services as a whole.ConclusionsPerceiving psychosis as something positive, a process of making sense of psychotic experiences and the ability to find external sources of strength all underpin—in addition to negative experiences with services—a choice to live with psychosis outside of services. Future research may explore to what extent these perceptions, psychological processes and abilities can be facilitated and strengthened, in order to support those people with psychosis who do not seek treatment and possibly also some of those who are in treatment.