bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malaria prevalence in children aged 0 -5 years in the commune of Ntoum , northwest Gabon
Authors: Meye Bourdettes , Kenguele Hilaire Moudounga , Mve Robert Eya'ama , Ekambou Ludjer Mpiga , Ondo Joseph privat , Engonga Louis Clément Obame 
Published: December 2024

Abstract

Background
In Gabon, the malaria burden among children five residing in the western corner of the Estuary province is unknown.
Methods
This prospective observational study was conducted over six (6) months, from June to December 2024, at NTOUM Regional (NR) Hospital. Blood samples were collected from 274 children attending the hospital, and analyzed using two different diagnostic methods (microscopy and rapid diagnostic test (RDT)). The socio-demographic data of the children's parents or guardians and the means of malaria prevention used in their household were recorded using a structured questionnaire. Data were then analyzed using R software version 4.1.2. Statistical significance was set at P < 0.05.
Results
189 blood samples were microscopically and immunochromatographically positive, representing a overall malaria prevalence of 69%. Very good agreement was observed between light microscopy and RDT (97.5%). Among all the independent variables considered in this study, only the unemployment was significantly associated with malaria (OR = 2.28; 95% CI = 1.2–4.35; P = 0.0118). Whereas, children vomiting were less likely to be infected with malaria (OR = 0.53; 95% CI = 0.29–0.99; P = 0.045) The parents or guardians of the children surveyed were mostly educated to secondary or university level (94.4%) and preferred insecticide - treated nets to aerosol insecticides (71% and 21.2% respectively).
Conclusion
Malaria is a major public health problem in Gabon. It affects particularly children under five year’s old living in the commune of Ntoum. To break the chain of malaria transmission in this part of the country, better access to malaria preventive measures is needed.
TOPIC: Comparative Analysis of the Antihypertensive Effects of Red Palm Oil and Pumpkin Seed Oil in Nω-Nitro-L-arginine Methyl Ester-Induced Hypertensive Rats
Authors: ADENIRAN Francis Temitope , OLADAPO Olulola Olutoyin 
Published: December 2024

Abstract

Background: Hypertension is a prevalent cardiovascular disease with global health implications. Dietary interventions with local Nigerian food items offer promise in hypertension management, but the comparative effects of Red Palm Oil (RPO) and Pumpkin Seed Oil (PSO) are underexplored. This study investigated the effects of RPO and PSO supplementation on hypertension in male Wistar rats, focusing on onset of action and effectiveness.
Methods: Thirty-six male adult Wistar rats were divided into six groups: control, RPO without hypertension induction, PSO without hypertension induction, RPO after hypertension induction, PSO after hypertension induction, and hypertension induction without supplementation. Hypertension was induced using Nω-Nitro-L-arginine methyl ester over three weeks, followed by five weeks of intervention. Blood pressure and weight were monitored weekly. RPO and PSO supplementation in normotensive rats showed no significant body weight changes.
Results: By week 4, hypertensive groups showed a significant weight reduction compared to normotensive groups. Both RPO and PSO reduced systolic blood pressure compared to hypertensive controls (162.17 ± 2.3 vs. 136.40 ± 0.75, 134.20 ± 1.53 mmHg). RPO showed earlier efficacy by week 5, while PSO's effect was significant by week 7. Both oils reduced diastolic blood pressure by week 6 (147.00 ± 9.04 vs. 96.00 ± 4.53, 93.00 ± 3.99 mmHg) and lowered mean arterial pressure (145.00 ± 1.34 vs. 109.00 ± 2.49, 115.67 ± 1.48 mmHg).
Discussion and Conclusion: Supplementation with red palm oil (RPO) or pumpkin seed oil (PSO) did not significantly affect heart weight index compared to the normal control group. Additionally, there were no significant differences between Red Palm Oil and Pumpkin Seed Oil when compared with the control and when compared within each condition. However, hypertension induction led to a significant change in heart weight index compared to the normal control group.
Analysis of the Increase in the Complexity of Care in Family Medicine
Authors: Montero Juan José , Seda-Gombau Gemma , Zamora-Sánchez María Victoria , Rodríguez-Álvarez Maria del Mar , López-Torrent Estíbaliz , Torán-Montserrat Pere 
Published: December 2024

Abstract

Objective: To analyze how the complexity of consultation among family physicians has evolved between 2019 and 2022.
Methods: Cross-sectional, prospective, multicenter, observational study. 31 health centers in Catalonia, Spain. Ninety physicians were selected by convenience sampling, and 26 repeated in each year of the study. Descriptive study in 3 cuts in years 2019, 2021, 2022. Continuous variables expressed in means and standard deviations and categorical variables in frequencies and percentages. In bivariate comparisons of categorical variables the chi-squared test was used, for continuous variables in two groups T-students test was used, and for comparison in three groups analysis of variance was used. Statistical test were performed with bilateral contrast and statistical significance of p-value<0.05.
Results: 17,473 visits and 23,998 reasons for consultation in a total of 599 days. From 2019 to 2022 the mean number of total visits per day increased from 27.8±5.0 to 31.5±8.4 (p-value= 0.042). The mean number of reasons per consultation increased from 39.2±8.6 to 44.8±16.3 (p-value=0.040). Psychosocial pathology increased from 3.15% to 4.49% (p-value<0.001). The unscheduled medical management time increased from 13.4 ± 16.6 to 20.7 ± 19.3 minutes (p-value<0.001). Complex visits increased from 33.2% in 2019 to 37.5% in 2022 (p-value<0.001), mostly due to emotional and communicative complexity. Face-to-face visits were the most that presented the highest complexity.
Conclusions: The overall complexity of consultations, which affects more than one-third of total visits, has increased by 12.9% since 2019, especially in face-to-face visits. Clinical, emotional, and communicative complexity have increased significantly.
Evaluation of volumetric and surface stability of calcium silicate-based repair cements at different pHs
Authors: Janini Ana Cristina Padilha , Alves Débora Leticia Bittencourt Leite , Santos Victor Augusto Benedicto dos , Moraes Brenda Fornazaro , Silva Nilvan Alves , Barros-Costa Matheus , Martins Luciano Augusto Cano , Neto Francisco Haiter , Marciano Marina Angélica 
Published: December 2024

Abstract

Objectives: The objective of this research was to evaluate the volumetric and surface stability of calcium silicate-based repair cements ready-to-use and powder/liquid exposed to different pH levels.
Materials and Methods: Sixty human teeth were retro-prepared to a depth of 3mm and divided into two groups. The first group included powder/liquid cements Biodentine (Septodont, France) and MTA HP (Angelus, Brazil); the second group included ready-to-use cements Bio-C Repair (Angelus, Brazil) and ENDOCEM MTA (Maruchi, Republic of Korea). All samples were submerged in PBS solution with pH levels of 5, 7, and 12. Initially, the materials were evaluated for porosity, marginal adaptation, and volumetric change using micro-CT, and then re-evaluated after 7 and 30 days of exposure to PBS solution. The samples were characterized using SEM/EDS and RAMAN spectroscopy. Statistical evaluation was performed using ANOVA with a 5% significance level.
Results: Bio-C Repair showed significant statistical differences (p<0.05) at different pHs in 7 and 30 days compared to other materials, being greater in acidic medium. ENDOCEM, regardless of pH, at 30 days showed fewer voids when compared to other repair cements.
Conclusion: This micro-CT study demonstrated that regardless pH, the clinic presentation of calcium silicate-based materials ready-to-use showed highest volumetric lost than powder/liquid materials at 30 days.
Clinical Relevance: Under neutral pH conditions, calcium silicate-based materials are expected to maintain properties such as bioactivity and low solubility. However, in clinical situations involving infection and inflammation, pH variations can impact the physicochemical properties of these materials regardless of their clinical presentation.
Decision Making on Multi-valued Rough Neutrosophic Set Using Index Method and Vikor Method
Authors: Gomathi K. , Deepa G. 
Published: December 2024

Abstract

Rough sets provide a robust mathematical framework for handling incomplete and uncertain information. This paper introduces a new approach to enhancing decision-making in university admissions process using Multi-Valued Rough Neutrosophic Sets (MVRNS). We propose two new multi-criteria decision-making (MCDM) methods, based on the Index and VIKOR method for MVRNS. The dataset used in this study is based on expert decision-making, ensuring relevance and accuracy in evaluating the criteria. By addressing uncertainty and vagueness in admission criteria, the proposed methods offer a more efficient and streamlined process compared to existing approaches. A numerical example is provided to demonstrate the practicality and effectiveness of the proposed methods in complex decision-making scenarios.
Kinesiophobia in patients with systemic sclerosis: relationship with functional status, pulmonary fibrosis, depression, and other clinical parameters
Authors: Pehlivan Canan Balamir , Sarıyıldız Mustafa Akif , Çevik Remzi , Erbatur Serkan , Batmaz İbrahim 
Published: December 2024

Abstract

Objectives: The aim of this study was to evaluate the levels of kinesiophobia and its relationship with functional status, quality of life, pulmonary involvement, depression, and other clinical parameters of the disease in patients with systemic sclerosis (SSc).
Patients and Methods: A total of 100 individuals (40 patients with SSc and 60 healthy controls) were included in the study. The Tampa scale was used to assess kinesiophobia. Beck Depression Inventory (BDI) was used to assess depression, Scleroderma Health Assessment Questionnaire (SSc-HAQ) was used to assess functional status, Modified Rodnan Skin Score was used to assess skin thickness, and high-resolution computed tomography was used to assess lung fibrosis.
Results: The mean Tampa kinesiophobia score was significantly higher in patients with SSc compared to healthy controls. Depressive symptoms were present in 57.5% of patients with SSc. Disease duration, pain, fatigue, disease activity, functional status, pulmonary fibrosis and depressive symptoms were correlated with kinesiophobia in patients with SSc.
Conclusion: There is an increased prevalence of kinesiophobia in patients with systemic sclerosis, which seems to be more closely associated with disease duration, pain levels, and depressive symptoms.
Gestational Diabetes Mellitus among Women of Advanced Maternal Age in Malaysia: A Study of the Prevalence and Sociodemographic Determinants
Authors: Chong Chean Tat , Palaniveloo Lalitha , Zain Sulhariza Husni , Khalil Muhamad Khairul Nazrin , Ratnam Kishwen Kanna Yoga 
Published: December 2024

Abstract

Background
Gestational diabetes mellitus (GDM) is a growing public health concern, particularly among women of advanced maternal age. Understanding the prevalence and associated sociodemographic factors is crucial for targeted interventions. This study aimed to determine the prevalence of GDM and its association with sociodemographic factors among Malaysian women of advanced maternal age.
Method
This study utilized data from the National Health and Morbidity Survey 2022: Maternal and Child Health, a nationwide survey employing a two-stage stratified random sampling design. GDM was diagnosed via a modified oral glucose tolerance test. Sociodemographic variables, including ethnicity, locality, education, employment, and household income, were analysed. Multiple logistic regression was performed to identify factors associated with GDM.
Results
The prevalence of GDM among women of advanced maternal age in Malaysia was 33.7%. Ethnicity was significantly associated with GDM, with Indian women having the highest prevalence (48.8%) and odds ratio (AOR: 7.31, 95% CI: 2.58–20.72; P < 0.001). Working status was another significant factor, with nonworking women having higher odds of GDM than working women (AOR: 1.34, 95% CI: 1.01–1.77; P = 0.003). No significant associations were observed for locality, educational level, or household income.
Conclusion
The high prevalence of GDM among women of advanced maternal age in Malaysia underscores the urgent need for targeted interventions, particularly among high-risk ethnic groups. Public health strategies should prioritize early screening, culturally tailored programs, and community-based initiatives to address this growing burden. Future research should explore behavioural and genetic determinants to further inform policy and practice.
Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB
Authors: Wang Zhiliang , Wu Di , Zhang Yue , Chen Weibo , Yang Yang , Yang Yue , Zu Guangchen , An Yong , Jin Yuchi , Kang Aining , Zou Yanxun , Liu Yi , Yu Xianjun , Qin Yi , Xu Xiaowu , Chen Xuemin 
Published: December 2024

Abstract

Pancreatic cancer is typically accompanied by fibrosis, forming a dense stromal matrix. This dense matrix restricts drug penetration, making it difficult for drugs to effectively reach tumor cells. Additionally, pancreatic cancer has inadequate local blood supply and "vascular irregularity," which makes it challenging for drugs to reach the core of the tumor. Even if some drugs reach the pancreas through systemic circulation, poor vascular permeability prevents them from effectively entering tumor cells, resulting in suboptimal therapeutic effects. Statins were initially used to treat high cholesterol levels and prevent cardiovascular diseases, but recent studies suggest that they may also have potential therapeutic effects on cancer, particularly certain types of cancer such as pancreatic cancer. However, clinical research on the use of statins for pancreatic cancer treatment is still ongoing, and the results are inconsistent. The effects of statins on pancreatic cancer may vary depending on the dose. Due to the aforementioned limitations of fibrosis and lack of blood supply in pancreatic cancer, simvastatin only exerts its effect on pancreatic cancer cells at low doses.The purpose of this study is to explore the effects of low-dose simvastatin on pancreatic cancer cells and the underlying mechanisms. We investigated the effects of different concentrations of simvastatin on pancreatic cancer cells. The vitality of the cells was evaluated by CCK8, EDU staining, and the level of ferroptosis in pancreatic cancer cells was detected by flow cytometry detection of C11, MDA, ROS. We found that small doses of simvastatin can resist the toxicity of Erastin against pancreatic cancer cells. Under the transmission electron microscope, more mitophagosomes were produced in pancreatic cancer cells treated with small dose of simvastatin, and immunofluorescence revealed increased co-localization of lysosomes and mitochondria, indicating that simvastatin promoted the occurrence of mitophagy. At the same time, immunofluorescence confirmed that simvastatin promoted the nuclear translocation of TFEB, and chromatin immunoprecipitation and dual-luciferase gene report confirmed that TFEB is the transcription factor of P62/SQSTM1. This study clarified that a small dose of simvastatin, in the event of mitochondrial stress in pancreatic cancer cells, induces mitophagy to clear damaged mitochondria, protecting pancreatic cancer cells from ferroptosis and apoptosis, by promoting the transcription of P62/SQSTM1 through the nuclear translocation of TFEB. These findings may explain one of the reasons for the suboptimal efficacy of simvastatin in the treatment of pancreatic cancer, while also providing new insights for research on the antitumor effects of statins.
Association between socioeconomic status and primary healthcare utilisation in Portugal
Authors: Madeira Francisco , Perelman Julian 
Published: December 2024

Abstract

Background
The public Portuguese primary health care (PHC) model includes a capitation component, where family physicians (FP) are partly financed based on a list of users, weighted by their age. Socioeconomic status (SES) has been identified as a potential factor influencing the utilisation of consultations, suggesting that the user list dimension should also be adjusted according to this parameter. This paper aims at measuring the association between SES and the use of PHC consultations, to identify whether SES should be used as adjustment factor in capitation.
Methods
The 2019 National Health Survey database (N = 10,115) was used to model the probability and frequency of PHC consultations as a function of SES variables, including educational level, income level, employment status, and insurance and subsystems status, adjusting for age, sex, and nationality. We employed a multivariable two-part model, and an adjustment for unmet needs was performed as additional analysis.
Results
Unemployed, retired, or disabled/inactive persons utilised PHC levels more frequently (0.09, 0.07 and 0.19 more consultations, respectively). In contrast, students, those with primary and lower secondary education, and those residing in a couple family household with children attended PHC facilities with less frequency (0.18 and 0.08 fewer consultations, respectively).
Conclusion
Specific SES determinants contribute to unequal levels of PHC use. A balanced, weight-adjusted combination of these factors in the formulation of PHC lists is key for optimising workloads while ensuring equitable provision of care aligned to population needs.
GIS-depend multi-standards result examination to rank appropriate places for irrigation with disciplined water
Authors: Askari Kaveh Ostad Ali , Kianmehr Peiman 
Published: December 2024

Abstract

The reprocess of preserved effluent for irrigation in arid and semi-arid zones benefits to decrease the increasing compression on conservative waters and recover nourishment safety. The aim of this effort is to trace and rank appropriate places for irrigation with disciplined water applying geospatial methods and multi-criteria investigation. The nominated investigation zone is restricted by the phreatic aquifer of Jaghin (Hormozgan province, Iran). The entire zone essential to captivate all sewages of the diverse effluent conduct floras of the district was designed applying FAO-56 technique for different cultivations. Different restrictions were designated and applied to define the appropriate zones for irrigation with disciplined water. The appropriate zone covers 360 Km which denotes 11.1% of the entire investigation zone. This establishes a big region much higher than the required zone to dampen the three agricultures with the complete capacity shaped by the four preserved effluent floras of the area. Eleven basic standards were recognized by nonfiction and specialists referring, spatialized applying GIS, weighted applying pair-wise contrast, consistent by fuzzy reason purposes and combined applying weighted linear mixture technique. The consequence is a plan that positions appropriate places for irrigation with disciplined water. The greatest-designated places are dispersed through the investigation zone. To decrease conveying price of preserved effluent and to simplify the irrigated region organization, the designated places are assembled in plans situated at the south-west of the investigation region. This effort is a valuable method to care choice creators for combined water organization. It should be completed by an inexpensive assessment of the scheme so as to measure the financial advantage of the repetition. Furthermore, a multi-goal examination should be measured to enhance the disciplined water recycle amongst irrigation and other usages, particularly the universal spread method, accomplished aquifers refresh.
РУССКАЯ НЕБОЛЬШЕВИСТСКАЯ ДИПЛОМАТИЯ ИПРОБЛЕМА КОНФЕРЕНЦИИ НА ПРИНЦЕВЫХ ОСТРОВАХ
Authors: Миронова Е.М. 
Published: December 2024

В статье предложен новый взгляд на обсуждаемый в историографии вопрос о конференции на Принцевых островах. Этот проект рассматривается в контексте борьбы русской небольшевистской дипломатии за право участвовать в Версальской мирной конференции. Изучены вновь введенные в научный оборот аналитические записки русских дипломатов, подготовленные в ходе и по итогам обсуждения проблемы.
This article gives us a new way of looking at the debated historiography question about the conference on the Princes Islands. This project is discussed in the context of Russian antiBolshevik diplomacy fight for the right to take part in the Versailles Peace conference. The article deals with rediscovered analytical notes of Russian diplomats, which were prepared during the conference and based on the outcomes of the discussion.
СОВЕТСКАЯ РОССИЯ – “МЕККА” ЛАТИНОАМЕРИКАНСКИХ РЕВОЛЮЦИОНЕРОВ. ОБРАЗ СТРАНЫ–“МЕССИИ”В ТРУДАХ ИНТЕЛЛЕКТУАЛОВ ЛАТИНСКОЙ АМЕРИКИ
Authors: Щелчков А.А. 
Published: December 2024

Латиноамериканская интеллигенция испытала огромное потрясение после первых известий о Российской революции 1917 г., а затем и провозглашения первого в мире социалистического государства. Первая влюбленность врусский эксперимент часто сменялась отрезвлением после личного знакомства среалиями советского режима и его практикой. Первые очерки путешественников, посетивших Советскую Россию по линии Коминтерна или ВОКСа, их непредвзятый взгляд на российскую революцию привел к глубокому размежеванию среди латиноамериканской интеллигенции на тех, кто принимал все советское, и тех, кто занял критическую позицию. Одно оставалось неизменным непрекращающийся интерес к происходящему в России и анализ сквозь призму русского опыта латиноамериканской действительности.
The Latin American intellectuals experienced a tremendous ideological and psychological shock after the first news of the Russian revolution of 1917 and the proclamation of the first socialist state. The first love to the Russian experiment often gave way to sobering up after a personal acquaintance with the realities of the Soviet regime and its practice. The first essays of travelers who visited Soviet Russia through the Comintern or VOKS, their unbiased view of the Russian revolution led to a deep division between the Latin American intelligentsia. One thing remained unchanged the continued interest in what was happening in Russia and analysis through the prism of the Russian experience of Latin American reality.