bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological and clinical burden associated with plexiform neurofibromas in pediatric neurofibromatosis type-1 (NF-1): a systematic literature review
Authors: Iheanacho Ike , Yoo Hyun Kyoo , Yang Xiaoqin , Dodman Sophie , Hughes Rachel , Amin Suvina 
Published: June 2021

Abstract
Purpose
Patients with neurofibromatosis type-1 (NF-1) and associated plexiform neurofibromas (PNs) often have a high burden of illness owing to debilitating symptoms of these tumors and limited management options. To investigate this complex disease, a systematic literature review (SLR) was conducted on the epidemiology of pediatric NF-1 and associated PNs, the burden of illness, and outcomes of surgical resection of these tumors.

Methods
Searches of MEDLINE and Embase (from database inception to October 2019) and conference proceedings (2017–2019) were performed to identify relevant studies. The review methodology was informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Results
Twenty studies were identified. Evidence confirmed NF-1 is rare but that occurrence may differ geographically. Only limited data on the birth incidence of NF-1 were identified. Prevalence estimates for pediatric NF-1 varied from one per 960 individuals (aged 17 years) to one per 5681 children (aged < 16 years) across five large registry/surveillance studies (each involving > 19,000 individuals). The prevalence of associated PNs was 0–29.6%. PNs carried increased mortality risk in pediatric NF-1 in both studies that explored this potential association. Patients with PNs reported high use of analgesics. The complication rate post-surgery for PNs was around 17–19%. The recurrence rate (18–68%) was dependent on the extent of excision achieved during surgery.

Conclusions
Data suggest NF-1 is a rare disease with increased morbidity and mortality in children with associated PNs. Surgical outcomes for PNs are often poor. These findings suggest significant unmet needs in patients with NF-1-associated PNs.
Clinical implementation of a 3D4K-exoscope (Orbeye) in microneurosurgery
Authors: Rösler Judith , Georgiev Stefan , Roethe Anna L. , Chakkalakal Denny , Acker Güliz , Dengler Nora F. , Prinz Vincent , Hecht Nils , Faust Katharina , Schneider Ulf , Bayerl Simon , Czabanka Marcus , Misch Martin , Onken Julia , Vajkoczy Peter , Picht Thomas 
Published: June 2021

AbstractExoscopic surgery promises alleviation of physical strain, improved intraoperative visualization and facilitation of the clinical workflow. In this prospective observational study, we investigate the clinical usability of a novel 3D4K-exoscope in routine neurosurgical interventions. Questionnaires on the use of the exoscope were carried out. Exemplary cases were additionally video-documented. All participating neurosurgeons (n = 10) received initial device training. Changing to a conventional microscope was possible at all times. A linear mixed model was used to analyse the impact of time on the switchover rate. For further analysis, we dichotomized the surgeons in a frequent (n = 1) and an infrequent (n = 9) user group. A one-sample Wilcoxon signed rank test was used to evaluate, if the number of surgeries differed between the two groups. Thirty-nine operations were included. No intraoperative complications occurred. In 69.2% of the procedures, the surgeon switched to the conventional microscope. While during the first half of the study the conversion rate was 90%, it decreased to 52.6% in the second half (p = 0.003). The number of interventions between the frequent and the infrequent user group differed significantly (p = 0.007). Main reasons for switching to ocular-based surgery were impaired hand–eye coordination and poor depth perception. The exoscope investigated in this study can be easily integrated in established neurosurgical workflows. Surgical ergonomics improved compared to standard microsurgical setups. Excellent image quality and precise control of the camera added to overall user satisfaction. For experienced surgeons, the incentive to switch from ocular-based to exoscopic surgery greatly varies.
The effects of caffeine in adults with neurogenic orthostatic hypotension: a systematic review
Authors: Gibbon Jake Ryan , Frith James 
Published: June 2021

Abstract
Purpose
To systematically review the evidence base for the effectiveness and safety of caffeine for the treatment of neurogenic orthostatic hypotension in adults.

Methods
Eight electronic databases were searched in January 2021. Original research studies or case reports involving adults with neurogenic orthostatic hypotension were included if caffeine was an intervention and outcomes included symptoms, blood pressure or adverse effects. Relevant studies were screened and underwent qualitative analysis. Insufficient reporting precluded meta-analysis.

Results
Five studies were identified: four crossover studies and one case report summation. Study size ranged from 5 to 16 participants. Participants had neurogenic orthostatic hypotension, with a mean standing systolic blood pressure of 86 mmHg. Two studies evaluated caffeine alone. Three studies administered caffeine in combination with ergotamine. Caffeine dose ranged from 100 to 300 mg. Nature and timing of outcomes measured varied between studies, with measurements being recorded from 30 to 480 min after intervention. Caffeine/ergotamine improved symptoms in one study and reduced orthostatic blood pressure drop in two studies. Caffeine/ergotamine increased seated blood pressure in three studies, whilst the results for caffeine alone were inconsistent. No serious adverse events were reported. All studies demonstrated high risk of bias.

Conclusion
Caffeine should only be considered as a treatment for adults with neurogenic orthostatic hypotension when evidence-based treatments have been exhausted.

Systematic review registration
PROSPERO ID: CRD42020124589. Date of registration: 30/10/2020
Exploring the Etiological Pathways of Problematic Pornography Use in NoFap/PornFree Rebooting Communities: A Critical Narrative Analysis of Internet Forum Data
Authors: Chasioti Dimitra , Binnie James 
Published: June 2021

AbstractProblematic pornography use (PPU) has been extensively studied in terms of its negative implications for various life domains. The empirical literature reveals measured outcomes of interpersonal and intrapersonal dysfunction in participants’ everyday living, supporting its classification as a disorder. The increasing number of complaints around PPU opens the door to the creation of online self-help rebooting communities. This qualitative study aimed to provide a better understanding of this behavior by investigating potential etiological pathways contributing to the onset of PPU, as they were expressed by members of the online NoFap/PornFree self-help communities with self-perceived PPU. The critical narrative analysis reveals a complex web of mutually informing causal connections. The dialectical relationship between situational resources, material conditions, and an embodied spectator gives rise to an online persona with motivations of self-exploration, experimentation, and socializing. A sense of vulnerability rendered the use of pornography as a means of escape and validation. Furthermore, commitment to abstinence, framed by the notions of recovery and relapse, was found to be a major factor for maintaining distress. The study highlighted the need for a thorough understanding of the etiological pathways of PPU for a more effective and targeted intervention. Moving beyond biomedical conceptualizations suggests an intervention whereby PPU is placed in a context of a crisis of meaning.
Traces of sunlight in the organic matter biogeochemistry of two shallow subarctic lakes
Authors: Rantala Marttiina V. , Meyer-Jacob Carsten , Kivilä E. Henriikka , Luoto Tomi P. , Ojala Antti. E. K. , Smol John P. , Nevalainen Liisa 
Published: June 2021

AbstractGlobal environmental change alters the production, terrestrial export, and photodegradation of organic carbon in northern lakes. Sedimentary biogeochemical records can provide a unique means to understand the nature of these changes over long time scales, where observational data fall short. We deployed in situ experiments on two shallow subarctic lakes with contrasting light regimes; a clear tundra lake and a dark woodland lake, to first investigate the photochemical transformation of carbon and nitrogen elemental (C/N ratio) and isotope (δ13C, δ15N) composition in lake water particulate organic matter (POM) for downcore inferences. We then explored elemental, isotopic, and spectral (inferred lake water total organic carbon [TOC] and sediment chlorophyll a [CHLa]) fingerprints in the lake sediments to trace changes in aquatic production, terrestrial inputs and photodegradation before and after profound human impacts on the global carbon cycle prompted by industrialization. POM pool in both lakes displayed tentative evidence of UV photoreactivity, reflected as increasing δ13C and decreasing C/N values. Through time, the tundra lake sediments traced subtle shifts in primary production, while the woodland lake carried signals of changing terrestrial contributions, indicating shifts in terrestrial carbon export but possibly also photodegradation rates. Under global human impact, both lakes irrespective of their distinct carbon regimes displayed evidence of increased productivity but no conspicuous signs of increased terrestrial influence. Overall, sediment biogeochemistry can integrate a wealth of information on carbon regulation in northern lakes, while our results also point to the importance of considering the entire spectrum of photobiogeochemical fingerprints in sedimentary studies.
Unravelling the Homicide Drop: Disaggregating a 25-Year Homicide Trend in the Netherlands
Authors: Aarten Pauline G.M. , Liem Marieke C.A. 
Published: June 2021

AbstractThe Western homicide drop is a known fact, but the reasons behind the drop have so far mainly focused on macro explanations. In this study, we argue that to understand the homicide drop, it is necessary to first explore whether the drop is general or specific. We do this by examining the subtypes of homicide together with perpetrator and victim demographic characteristics. This study seeks to describe the nature and scope of homicidal violence in the period 1992–2016 in the Netherlands, disaggregating by subtype of homicide, and perpetrator and victim gender constellation and age. In doing so, we make use of the Dutch Homicide Monitor. Findings show that the Dutch homicide drop is significantly related to homicides resulting from disputes and robberies and intimate partner homicides. The gender constellation and age distribution in all homicide types are further explored. This study highlights the importance of disaggregating data by subtype in unravelling the homicide drop.
What affordances do open-ended real-life tasks offer for sharing student agency in collaborative problem-solving?
Authors: Nieminen Juuso Henrik , Chan Man Ching Esther , Clarke David 
Published: June 2021

AbstractThe important role of student agency in collaborative problem-solving has been acknowledged in previous mathematics education research. However, what remains unknown are the processes of agency in open-ended tasks that draw on real-life contexts and demand argumentation beyond “mathematical”. In this study, we analyse a video recording of two student groups (each consisting of four students) taking part in collaborative problem-solving. We draw on the framework for collaborative construction of mathematical arguments and its interplay with student agency by Mueller et al. (2012). This original framework is supplemented by (i) testing and revising it in the context of open-ended real-life tasks, with (ii) student groups rather than pairs working on the tasks, and by (iii) offering a strengthened methodological pathway for analysing student agency in such a context. Based on our findings, we suggest that the framework suits this new context with some extensions. First, we note that differences in student agency were not only identified in terms of the discourse students drew on, but in how students were able to shift between various discourses, such as between “mathematical” and “non-mathematical” discourses. We identify a novel discourse reflecting student agency, invalidation discourse, which refers to denying other students’ agency by framing their contribution as invalid. Finally, we discuss the need to reframe “mathematical” arguments—and indeed student agency—while the task at hand is open-ended and concerns real-life contexts.
The “Big Two” and socially induced emotions: Agency and communion jointly influence emotional contagion and emotional mimicry
Authors: Wróbel Monika , Piórkowska Magda , Rzeczkowska Maja , Troszczyńska Adrianna , Tołopiło Aleksandra , Olszanowski Michał 
Published: June 2021

AbstractThree studies investigated the effects of two fundamental dimensions of social perception on emotional contagion (i.e., the transfer of emotions between people). Rooting our hypotheses in the Dual Perspective Model of Agency and Communion (Abele and Wojciszke in Adv Exp Soc Psychol 50:198–255,10.1016/B978-0-12-800284-1.00004-7, 2014), we predicted that agency would strengthen the effects of communion on emotional contagion and emotional mimicry (a process often considered a key mechanism behind emotional contagion). To test this hypothesis, we exposed participants to happy, sad, and angry senders characterized by low vs. high communion and agency. Our results demonstrated that, as expected, the effects of the two dimensions on socially induced emotions were interactive. The strength and direction of these effects, however, were consistent with our predictions only when the senders expressed happiness. When the senders expressed sadness, we found no effects of agency or communion on participants’ emotional responses, whereas for anger a mixed pattern emerged. Overall, our results align with the notion that emotional contagion and mimicry are modulated not only by the senders’ traits but also by the social meaning of the expressed emotion.
Enhancing spatial perception through sound: mapping human movements into MIDI
Authors: Breve Bernardo , Cirillo Stefano , Cuofano Mariano , Desiato Domenico 
Published: June 2021

AbstractGestural expressiveness plays a fundamental role in the interaction with people, environments, animals, things, and so on. Thus, several emerging application domains would exploit the interpretation of movements to support their critical designing processes. To this end, new forms to express the people’s perceptions could help their interpretation, like in the case of music. In this paper, we investigate the user’s perception associated with the interpretation of sounds by highlighting how sounds can be exploited for helping users in adapting to a specific environment. We present a novel algorithm for mapping human movements into MIDI music. The algorithm has been implemented in a system that integrates a module for real-time tracking of movements through a sample based synthesizer using different types of filters to modulate frequencies. The system has been evaluated through a user study, in which several users have participated in a room experience, yielding significant results about their perceptions with respect to the environment they were immersed.
Grief, disorientation, and futurity
Authors: Mehmel Constantin 
Published: June 2021

AbstractThis paper seeks to develop a phenomenological account of the disorientation of grief, specifically the relationship between disorientation and the breakdown in practical self-understanding at the heart of grief. I argue that this breakdown cannot be sufficiently understood as a breakdown of formerly shared practices and habitual patterns of navigating lived-in space that leaves the bereaved individual at a loss as to how to go on. Examining the experience of losing a loved person and a loved person-to-be, I instead propose that this breakdown should be understood primarily in relation to a distinctive kind of futurity operative in disorientation, irrespective of the extent to which there is a breakdown of formerly shared practices and habitual patterns of navigating lived-in space. Drawing on the resources afforded by Heidegger’s phenomenology, I argue that it is a core characteristic of the experience of disorientation in grief that the grieving person can no longer meaningfully press ahead into a specific futural self. This view comes with certain advantages over existing accounts of the temporality of grief for making sense of the disorientated relationship to futurity, which the appeal to Heideggerian resources makes possible.
Executives vs. governance: Who has the predictive power? Evidence from narrative tone
Authors: Bassyouny Hesham , Abdelfattah Tarek 
Published: June 2021

AbstractThis study aims to investigate not only Narrative Disclosure Tone predictive power, but also who has this power within companies to predict future performance in the UK context (executive vs. governance). We conduct a computerized textual analysis to measure the tone of UK annual reports narratives. Our results contribute to accounting and financial reporting literature by showing that corporate narrative tone can predict future performance. However, answering our main question about who has this predictive power, we found executives’ reporting tone has the power to predict a company’s future performance but not governance tone. Considering the moderation effect of the 2014 financial reporting guidance, we found this guidance increases corporate narrative tone power in general and executive tone in particular in predicting future performance. Moreover, the current study contributes to financial reporting literature by providing a UK evidence, which operates under the principles-based approach with more flexibility in financial reporting than the US context that follows the rules-based approach. Finally, this study has practical implications for regulators and external users of financial reporting.
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy
Authors: Maresca Kevin P. , Chen Jianqing , Mathur Divya , Giddabasappa Anand , Root Adam , Narula Jatin , King Lindsay , Schaer David , Golas Jonathan , Kobylarz Keith , Rosfjord Edward , Keliher Edmund , Chen Laigao , Ram Sripad , Pickering Eve H. , Hardwick James S. , Rejto Paul A. , Hussein Amira , Ilovich Ohad , Staton Kevin , Wilson Ian , McCarthy Timothy J. 
Published: June 2021

Abstract
Purpose
A sensitive and specific imaging biomarker to monitor immune activation and quantify pharmacodynamic responses would be useful for development of immunomodulating anti-cancer agents. PF-07062119 is a T cell engaging bispecific antibody that binds to CD3 and guanylyl cyclase C, a protein that is over-expressed by colorectal cancers. Here, we used 89Zr-Df-IAB22M2C (89Zr-Df-Crefmirlimab), a human CD8-specific minibody to monitor CD8+ T cell infiltration into tumors by positron emission tomography. We investigated the ability of 89Zr-Df-IAB22M2C to track anti-tumor activity induced by PF-07062119 in a human CRC adoptive transfer mouse model (with injected activated/expanded human T cells), as well as the correlation of tumor radiotracer uptake with CD8+ immunohistochemical staining.

Procedures
NOD SCID gamma mice bearing human CRC LS1034 tumors were treated with four different doses of PF-07062119, or a non-targeted CD3 BsAb control, and imaged with 89Zr-Df-IAB22M2C PET at days 4 and 9. Following PET/CT imaging, mice were euthanized and dissected for ex vivo distribution analysis of 89Zr-Df-IAB22M2C in tissues on days 4 and 9, with additional data collected on day 6 (supplementary). Data were analyzed and reported as standard uptake value and %ID/g for in vivo imaging and ex vivo tissue distribution. In addition, tumor tissues were evaluated by immunohistochemistry for CD8+ T cells.

Results
The results demonstrated substantial mean uptake of 89Zr-Df-IAB22M2C (%ID/g) in PF-07062119-treated tumors, with significant increases in comparison to non-targeted BsAb-treated controls, as well as PF-07062119 dose-dependent responses over time of treatment. A moderate correlation was observed between tumor tissue radioactivity uptake and CD8+ cell density, demonstrating the value of the imaging agent for non-invasive assessment of intra-tumoral CD8+ T cells and the mechanism of action for PF-07062119.

Conclusion
Immune-imaging technologies for quantitative cellular measures would be a valuable biomarker in immunotherapeutic clinical development. We demonstrated a qualification of 89Zr-IAB22M2C PET to evaluate PD responses (mice) to a novel immunotherapeutic.
Asymmetry in information acquisition—Exploring the principal–agent dyad of sport organizations and sport management higher education institutions
Authors: Wohlfart Olivia , Adam Sandy , Hovemann Gregor 
Published: June 2021

AbstractThis study is based on a metaphorical contract in sport management, whereby sport organizations (the principal) engage sport management higher education institutions (the agent) in qualifying graduates according to industry demands. There is asymmetry in the contract due to the lack of incentives for the principal to provide specific information and the agent’s ignorance about this information. A third party can acquire crucial information that sport management higher education institutions need to fulfil the contract. Based on a qualitative content analysis of 12 interviews with sport organization representatives, the study finds that sport management higher education institutions need to focus on either developing generic competencies or credibly signalling the value of sport management-specific competencies in their curriculum in order to efficiently fulfil the contract.
Sex/gender considerations in school-based interventions to promote children’s and adolescents’ physical activity
Authors: Schlund Annegret , Reimers Anne K. , Bucksch Jens , Linder Stephanie , Demetriou Yolanda 
Published: June 2021

AbstractPhysical inactivity is an increasing problem worldwide, but especially among girls. This difference by gender increases with age. Schools serve virtually all young people in most parts of the world and can thus play an important role in promoting physical activity. In this systematic review, we qualitatively and comprehensively assessed the treatment of sex/gender considerations (from study design to discussion of results) in 56 school-based intervention studies aiming to promote physical activity in children and adolescents. In all 56 studies, the factor of sex/gender was only rudimentarily considered, regardless of the effectiveness of the intervention. The meta-analysis revealed that the interventions had significant but relatively small effects with both girls and boys, along with high heterogeneity. To obtain better information about effective strategies that promote physical activity for both girls and boys equally, researchers conducting future intervention studies should pay attention to sex/gender differences and report on how they take this factor into account.