bluuebunny/crossref_metadata_2025_split huggingface dataset:
High levels of interleukin-6 are associated with final infarct size and adverse clinical events in patients with STEMI
Authors: Tøllefsen Ingvild Maria , Shetelig Christian , Seljeflot Ingebjørg , Eritsland Jan , Hoffmann Pavel , Andersen Geir Øystein 
Published: December 2021

ObjectiveInflammation has emerged as a new treatment target in patients with coronary artery disease and inflammation seems to play an important role in ischaemia/reperfusion injury that follows ST-elevation myocardial infarction (STEMI). We aimed to explore the role of acute and sustained interleukin 6 (IL-6) signalling, including soluble IL-6 receptor (IL-6R), with regard to infarct size, adverse remodelling and future cardiovascular events in patients with STEMI.MethodsWe included 269 patients with first-time STEMI, symptom duration <6 hours and treated with percutaneous coronary intervention. Blood sampling and cardiac MRI were performed in the acute phase and after 4 months. Clinical events and all-cause mortality were registered during 12-month and 70-month follow-up, respectively.ResultsIL-6 levels above median at all sampling points were significantly associated with increased infarct size and reduced left ventricular ejection fraction (LVEF). IL-6 levels in the highest quartile were at all sampling points associated with an increased risk of having an adverse clinical event during the first 12 months and with long-term all-cause mortality. IL-6R was not associated with infarct size, LVEF, myocardial salvage or long-term all-cause mortality.ConclusionAcute and sustained elevation of IL-6 measured 4 months after STEMI were associated with larger infarct size, reduced LVEF and adverse clinical events including all-cause mortality. The results add important information to the sustained role of inflammation in patients with STEMI and IL-6 as a potential target for long-term intervention.Trial registration numberNCT00922675.
Accelerating LHC phenomenology with analytic one-loop amplitudes
Authors: Campbell John M. , Höche Stefan , Preuss Christian T. 
Published: December 2021

AbstractThe evaluation of one-loop matrix elements is one of the main bottlenecks in precision calculations for the high-luminosity phase of the Large Hadron Collider. To alleviate this problem, a new C++ interface to the "Image missing" parton-level Monte Carlo is introduced, giving access to an extensive library of analytic results for one-loop amplitudes. Timing comparisons are presented for a large set of Standard Model processes. These are relevant for high-statistics event simulation in the context of experimental analyses and precision fixed-order computations.
Pareidolia and the Pitfalls of Subjective Interpretation of Ambiguous Images in Art History
Authors: Wilner Raquel G. 
Published: December 2021

Abstract
In art history, we sometimes discover hidden images within a picture and conduct a subjective introspective analysis of the motivation behind these images. The author argues that many such highly ambiguous hidden images are better explained by the pareidolia phenomenon: the tendency to find patterns in random stimuli. The arguments brought forth by Sidney Geist and Dario Gamboni illustrate the pitfalls and controversy of subjective visual analysis and how a perceptual phenomenon can mislead our conclusions. This article proposes that this controversy can be approached by establishing pictorial intent: Did the artist deliberately paint the hidden image, or is it merely a perceptual artifact?
More than the sum of its parts: Merging network psychometrics and network neuroscience with application in autism
Authors: Bathelt Joe , Geurts Hilde M. , Borsboom Denny 
Published: December 2021

Abstract
Network approaches that investigate the interaction between symptoms and behaviours have opened new ways of understanding psychological phenomena in health and disorder in recent years. In parallel, network approaches that characterise the interaction between brain regions have become the dominant approach in neuroimaging research. In this paper, we introduce a methodology for combining network psychometrics and network neuroscience. This approach utilises the information from the psychometric network to obtain neural correlates that are associated with each node in the psychometric network (network-based regression). Moreover, we combine the behavioural variables and their neural correlates in a joint network to characterise their interactions. We illustrate the approach by highlighting the interaction between the triad of autistic traits and their resting-state functional connectivity associations. To this end, we utilise data from 172 male autistic participants (10–21 years) from the autism brain data exchange (ABIDE, ABIDE-II) that completed resting-state fMRI and were assessed using the autism diagnostic interview (ADI-R). Our results indicate that the network-based regression approach can uncover both unique and shared neural correlates of behavioural measures. For instance, our example analysis indicates that the overlap between communication and social difficulties is not reflected in the overlap between their functional brain correlates.
A Critical Assessment of Turkish Islamic Feminism
Authors: Kanatli Mehmet 
Published: December 2021

Abstract
From the early years of the Turkish Republic to the end of the 1990s, the individuals who constitute the Turkish Islamic feminist movement have been the ‘other’ to Kemalist secular women. In the mid-2000s, having found a solution to the ‘headscarf question’, Muslim women started to express their demands, ranging from equal opportunities in education to the transformation of patriarchal structures and the reconstruction of female identity. The article’s main objective is to develop arguments for how dilemmas can be transcended in the process of identity-building. The main hypothesis put forward is that the participants in the Turkish Islamic feminist movement, who could turn their dilemmas into advantages if they managed to establish their relationship with the ‘other’ in line with the universal secular values of equality and freedom, will achieve their existential freedom only to the extent that they are able to act from an existential perspective.
An additional new species and records of Neoperla Needham, 1905 (Plecoptera, Perlidae) from the Philippines
Authors: Pelingen Arthien Lovell , Murányi Dávid , Freitag Hendrik 
Published: December 2021

Abstract
We report a new species and new records of Neoperla species from the Philippines. Neoperla pangantihoni sp. n. from Palawan is described, and for the first time, a stonefly species, N. atropennis Banks, 1924, is recorded from Camiguin. We also provide supplementary descriptions for N. recta Banks, 1913, N. sabang Sivec & Stark, 2011, and N. salakot Sivec & Stark, 2011. Furthermore, these morphological diagnoses are coupled with COI barcodes analyzed using pairwise distances and a statistical haplotype network.
Time to Abolish the Forced Swim Test in Rats for Depression Research?
Authors: Carvalho Constança , Herrmann Kathrin , Marques Tiago A. , Knight Andrew 
Published: December 2021

Abstract
The forced swim test (FST) is a controversial rodent test that has been used for decades, mainly in depression studies. The severity of the procedure makes it ethically questionable and its validity has also been questioned. In this paper we contribute new data to this debate. We identified original research papers related to Major Depressive Disorder (MDD), using rats as models. We compared the citations received by studies that used the FST and by studies that did not, within subsequent human medical papers. The results show that the number of citations received by both groups was very low, but in the papers describing the FST data the median citation number was zero. Citation analysis indicates that the FST is not contributing significantly to the understanding or cure of MDD. We briefly review other approaches that overcome the ethical limitations of the FST, and which might also surpass its efficacy.
Observing Profiles of Derived Kinematic Field Quantities Using a Network of Profiling Sites
Authors: Wagner Timothy J. , Turner David D. , Heus Thijs , Blumberg William G. 
Published: December 2021

Abstract
Observations of thermodynamic and kinematic parameters associated with derivatives of the thermodynamics and wind fields, namely, advection, vorticity, divergence, and deformation, can be obtained by applying Green’s theorem to a network of observing sites. The five nodes that comprise the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) profiling network, spaced 50–80 km apart, are used to obtain measurements of these parameters over a finite region. To demonstrate the applicability of this technique at this location, it is first applied to gridded model output from the High-Resolution Rapid Refresh (HRRR) numerical weather prediction model, using profiles from the locations of ARM network sites, so that values calculated from this method can be directly compared to finite difference calculations. Good agreement is found between both approaches as well as between the model and values calculated from the observations. Uncertainties for the observations are obtained via a Monte Carlo process in which the profiles are randomly perturbed in accordance with their known error characteristics. The existing size of the ARM network is well suited to capturing these parameters, with strong correlations to model values and smaller uncertainties than a more closely spaced network, yet it is small enough that it avoids the tendency for advection to go to zero over a large area.
The Ability of the ICE-T Microphysics Scheme in HARMONIE-AROME to Predict Aircraft Icing
Authors: Engdahl Bjørg Jenny Kokkvoll , Carlsen Tim , Køltzow Morten , Storelvmo Trude 
Published: December 2021

AbstractIn-cloud icing is a major hazard for aviation traffic and forecasting of these events is an important task for weather agencies worldwide. A common tool utilized by aviation forecasters is an icing intensity index based on supercooled liquid water from numerical weather prediction models. We seek to validate the modified microphysics scheme, ICE-T, in the HARMONIE-AROME numerical weather prediction model with respect to aircraft icing. Icing intensities and supercooled liquid water derived from two 3-month winter season simulations with the original microphysics code, CTRL, and ICE-T are compared with pilot reports of icing and satellite retrieved values of liquid and ice water content fromCloudSat–CALIPSOand liquid water path from AMSR-2. The results show increased supercooled liquid water and higher icing indices in ICE-T. Several different thresholds and sizes of neighborhood areas for icing forecasts were tested out, and ICE-T captures more of the reported icing events for all thresholds and nearly all neighborhood areas. With a higher frequency of forecasted icing, a higher false alarm ratio cannot be ruled out, but is not possible to quantify due to the lack of no-icing observations. The increased liquid water content in ICE-T shows a better match with the retrieved satellite observations, yet the values are still greatly underestimated at lower levels. Future studies should investigate this issue further, as liquid water content also has implications for downstream processes such as the cloud radiative effect, latent heat release, and precipitation.
Revisited the Relationship Between Economic Growth and Transport Infrastructure in India: An Empirical Study
Authors: Ghosh Prabir Kumar , Dinda Soumyananda 
Published: December 2021

This study empirically re-examines the relationship between transport infrastructure and economic growth in India for the period 1990–2017. Multivariate dynamic models are applied to estimate the relationship between economic growth and different modes of transport infrastructure namely road, rail and air transports in the vector error correction model framework. The results reveal that road and air transports have significant positive contribution to economic growth in the long-run while rail transport is insignificant. This study further examines the said issue using unit free index variables and has constructed a composite index of transport infrastructure using principal component analysis to analyse the nexus between aggregate transport infrastructure and economic growth in India in the post globalisation era. The results of the study indicate the bidirectional causality between aggregate transport infrastructure and economic growth. Results of this study suggest incorporating feedback issue in policy formulations. JEL Codes: C22, O18, R4
Import Demand Function in India Under the Liberalised Trade Regime
Authors: Chakraborty Moutushi , Maitra Biswajit 
Published: December 2021

The trade liberalisation policy was initiated in India in the 1980s but executed effectively since the early 1990s. Since then India’s foreign trade embarks on a new road with a rapid expansion of export and import. Over the period, import exceed export. Identifying factors influencing such a significant elevation of import is a relevant issue of research. This study appraises import demand function in India for the liberalised trade regime particularly, for an extended period 1980–2018, and for the post-reform period, 1992–2018. The study identifies domestic income in aggregated and disaggregated level with exchange rate, trade openness and population growth as significant determinants of import demand. The income has a positive impact on import demand, where income elasticity of import demand differs significantly across the aggregate income and its components—consumption, investment and export expenditure. The exchange rate has a negative impact, implies a depreciation of Indian currency decrease import demand. The trade openness causes a rise in import demand both in the long run and in the short run. Population growth also raises import demand. The econometric diagnostics corroborate the fact that the estimated import demand functions are stable and robust. JEL Codes: F10, F14, C22
Filling in the (gendered) gaps: How observers frame claims of sexual assault
Authors: Mulder Eva , Bosma Alice Kirsten 
Published: December 2021

Claims of sexual assault are especially prone to scrutiny and (re)interpretation as something else. We investigated how people judged the veracity of sexual assault claims and how they subsequently framed their interpretations of these claims using ‘general knowledge’ in the form of sexual scripts, rape myths, and gender stereotypes. Participants ( n = 161) read about a sexual assault allegation by a male or female claimant and were asked to describe in more detail what they thought had happened. Data were analyzed using a combination of quantitative and qualitative frame analysis. A key finding was that although participants mostly accepted the facts of the claim, this did not automatically imply they shared the claimant’s interpretation of the event as (serious) sexual assault. The analysis revealed that participants drew upon distinct frames to interpret the claim, including frames – such as regretted consensual sex and miscommunication – that exonerated the accused and emphasized claimant responsibility. Frames were differentially employed in response to male and female claims of sexual assault. We discuss how our research design and findings can contribute to an increased understanding of the underlying mechanisms of victim acknowledgment.
Clinical and Economic Impact of Pharmacists’ Intervention on Care of Pediatric Hematology and Oncology Patients
Authors: Kim Hyun Jee , Lee Sunghee , Lee Yu Jin , Kim Sunghwan , Jo Yun Hee , Cho Yoon-Sook , An Hong Yul , Hong Kyung Taek , Choi Jung Yoon , Kang Hyoung Jin , Shin Hee Young , Lee Ju-Yeun 
Published: December 2021

Introduction Children with cancer may be one of the most vulnerable groups to drug-related adverse events because they possess characteristics of patients with cancer as well as pediatric patients. To evaluate the clinical and economic impact of pharmacists’ intervention on the care of pediatric hematology and oncology patients in the inpatient and outpatient settings of a children's hospital. Methods The pharmacist-intervention records from 2017 were retrospectively reviewed. Intervention rate, type of drug-related problems, acceptance rate, and frequently involved drugs in pharmacist interventions were analyzed. One physician and one pharmacist evaluated the clinical significance of each intervention. A cost-benefit analysis was conducted from hospital and patient perspective. The benefit from cost savings by reducing the number of prescribed drugs that are disposed was estimated as the benefit from hospital perspective. The benefit from cost avoidance based on the potential to avoid an adverse drug event (ADE) was estimated as the benefit from patient perspective. The cost of reviewing prescriptions was estimated based on the pharmacists’ salary and the time involved. Results In 2017, 2361 interventions were performed in 381 pediatric patients with cancer. The acceptance rate was 97.2%. More than half of the interventions were regarded as clinically “significant” (58.8%) and “very significant” (14.6%). The cost-benefit of US$28,705 was determined from hospital perspective, with a cost-benefit ratio of 1.45:1. The cost-benefit of US$35,611 was calculated from patient perspective, with a cost-benefit ratio of 1.55:1. Conclusions Pharmacists’ intervention in the care of hematology and oncology pediatric patients was effective in preventing clinically significant ADEs and had a positive economic impact on the health-care budget from both hospital and patient perspective.
Expression of Programmed Cell Death-L1 (PD-L1) Protein and Mismatch Repair Mutations in Orbital Tumours-a Pilot Study
Authors: AlSemari Mohammad A , Strianese Diego , Abu Safieh Leen , Al Hussain Hailah , Abedalthagafi Malak , Edward Deepak P. 
Published: December 2021

Purpose Programmed cell death protein 1 (PD-1) and DNA mismatch repair (MMR) deficiency play an important role in tumour progression and response to treatment. Both markers have been studied in some ocular tumours but little is known about these markers in orbital tumours. This pilot study reports on PD-L1 expression and MMR mutations using next generation sequencing (NGS) in specific orbital tumours. Methods We reviewed surgical specimens from patients with rhabdomyosarcoma, adenoid cystic carcinoma (ACC), pleomorphic adenoma (PA) and biopsy negative tissue from orbital tumours used as a control. immunohistochemistry (IHC) was performed on Formalin fixed paraffin embedded tissue using a PD-L1 antibody. DNA was extracted for targeted gene panel NGS of the MMR genes PMS2, MLH1, MSH6 and MSH2. Results The study included 17 orbital specimens. Scattered membrane PD-L1 staining was noted in 3/6 rhabdomyosarcoma specimens without an accompanying lymphocytic infiltrate. PD-L1 immunostaining was absent in 3/3 ACC, and 5/6 PA specimens. PD-L1 immunostaining was not detected in 2/2 control specimens. 4/17 samples shared the same pathogenic mutation in the MLH1 gene, including 3/6 rhabdomyosarcoma and 1/3 ACC samples. 1/6 PA samples had a mutation in MSH6. Conclusions Our study demonstrated scattered, non-quantifiable or absent PD-L1 staining in a limited sample of orbital tumours suggesting that PD-1/PD-L1 inhibitor therapy may not be useful in treatment of malignant orbital tumours (rhabdomyosarcoma and ACC) when refractory to conventional therapy. Our pilot study suggest that PD-L1/MMR axis might not play a major role in the pathogenesis of primary orbital tumour.
Prevalence and Risk Factors of Dry Eye Symptoms after Successful Dacryocystorhinostomy for Patients with Lacrimal Passage Obstruction
Authors: Jin Yu , Guo Yining , Liu Yushi , Wang Yuexin , Qin Guijuan , Tian Yanjie , Li Xuemin 
Published: December 2021

Purpose To investigate the prevalence of dry eye symptoms after successful dacryocystorhinostomy and explore the potential risk factors. Methods This cross-sectional study included 565 patients with lacrimal passage obstruction (LPO) who underwent external dacryocystorhinostomy. Ocular Surface Disease Index (OSDI) total score of 13 or more was regarded as presence of dry eye symptoms. OSDI total score greater than 22 combined with self-reported dry eye was defined as symptomatic dry eye. Logistic regression and linear regression were used to examine the associations between OSDI scores and its potentially predictive factors. Results Of the 565 patients, 344 completed the questionnaire, among which 101(29.4%) patients presented with dry eye symptoms, including 53(15.4%) mild, 14(4.1%) moderate and 34(9.9%) severe, and 48(14.0%) patients can be defined as symptomatic dry eye. Univariate logistic regression revealed that age, educational levels, income levels, and hypertension were significantly correlated with the presence of dry eye symptoms ( P < 0.05). After multivariate adjustment, lower income levels were found significantly associated with dry eye symptoms ( P < 0.05). Univariate linear regression demonstrated that age, lower educational levels, surgery history, and hypertension were significantly associated with OSDI total score ( P = 0.037, 0.012, 0.022, 0.029 respectively). Multivariate stepwise linear regression manifested that educational levels and the surgery history influenced the OSDI total score mostly ( P = 0.021, 0.036 respectively). Conclusions Dry eye problem of LPO patients after successful dacryocystorhinostomy cannot be ignored. In the preoperative evaluation, we should pay special attention to the elderly patients with lower educational levels, lower income levels or systemic diseases.
Visual Evoked Potentials in Neuromyelitis Optica Spectrum Disorders
Authors: Hernandez Fustes Otto Jesus , Kay Cláudia S K , Lorenzoni Paulo José , Ducci Renata D-P , Werneck Lineu C , Scola Rosana Herminia 
Published: December 2021

Background Neuromyelitis optica spectrum disorders (NMOSDs) are rare antibody-mediated disorders of the central nervous system, with a predilection for the spinal cord and optic nerves. The clinical utility of evoked potential recordings (EPs) has already been established for multiple sclerosis, in particular, that of the abnormal visual evoked potentials (VEP), a key criterion in the McDonald diagnostic criteria for MS. However, there have been few reports on EPs in patients with NMOSD. AIM The aim of our study was to assess the possible involvement of the optical pathway through VEP responses in patients with NMOSD. Methods VEPs were prospectively performed in 13 patients with NMOSD. All the patients were recruited from the outpatient clinic of a demyelinating diseases center. The recording was done as recommended by the International Federation of Clinical Neurophysiology. Results We evaluated the eyes of 12 women with a mean age of 42 years and of one man who was 25 years old. In 6 of the examined eye samples, a response was not obtained, while in the remaining 20 eye samples, we found a significant increase in P100 latency without amplitude change. Conclusion VEPs showed a significant increase in P100 latency. VEP assessment is a non-invasive, painless, fast, and low-cost exam that provides neurophysiological data for diagnosis of NMOSD.