bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpretable prediction of drug‐cell line response by triple matrix factorization
Authors: Yan Xiao‐Ying , Zhang Shao‐Wu , Yiu Siu‐Ming , Shi Jian‐Yu 
Published: June 2021

BackgroundOne of the challenges in personalized medicine is to determine specific drugs and their dosages for patient individuals who are undergoing a common disease. The technique of cell lines provides a safe approach to capture the drug responses of patient individuals when given specific drugs with varied dosages. However, it is still costly to determine drug responses in cells w.r.t dosages by biological assays. Computational methods provide a promising screening to infer possible drug responses in the cells of patient individuals on a large scale. Nevertheless, existing computational approaches are insufficient to interpret the underlying reason for drug responses.MethodsIn this work, we propose an interpretable model for analyzing and predicting drug responses across cell lines. The proposed model bridges drug features ( e.g., chemical structure fingerprints), cell features ( e.g., gene expression profiles), and drug responses across cells (measured by IC50) by a triple matrix factorization (TMF), such that the underlying reason for drug responses in specific cells is possibly interpreted.ResultsThe comparison with state‐of‐the‐art computational approaches demonstrates the superiority of our TMF. More importantly, a case study of drug responses in lung‐related cell lines shows its interpretable ability to find out highly occurring drug substructures, crucial mutated genes, as well as significant pairs between substructures and mutated genes in terms of drug sensitivity and resistance.ConclusionTMF is an effective and interpretable approach for predicting cell lines responses to drugs, and can dig out crucial pairs of chemical substructures and genes, which uncovers the underlying reason for drug responses in specific cells.
COVID-19 and Adolescent Depression and Suicide Risk Screening Outcomes
Authors: Mayne Stephanie L. , Hannan Chloe , Davis Molly , Young Jami F. , Kelly Mary Kate , Powell Maura , Dalembert George , McPeak Katie E. , Jenssen Brian P. , Fiks Alexander G. 
Published: June 2021

BACKGROUNDMental health concerns increased during the coronavirus disease 2019 pandemic, but previous studies have not examined depression screening in pediatric primary care. We aimed to describe changes in screening, depressive symptoms, and suicide risk among adolescents during the coronavirus disease 2019 pandemic.METHODSIn a repeat cross-sectional analysis of electronic health record data from a large pediatric primary care network, we compared the percentage of primary care visits where adolescents aged 12 to 21 were screened for depression, screened positive for depressive symptoms, or screened positive for suicide risk between June and December 2019 (prepandemic) and June and December 2020 (pandemic). Changes were examined overall, by month, and by sex, race and ethnicity, insurance type, and income. Modified Poisson regression was used to calculate prevalence ratios (PRs) for the prepandemic to pandemic changes.RESULTSDepression screening at primary care visits declined from 77.6% to 75.8% during the pandemic period (PR: 0.98, 95% confidence interval [CI]: 0.90–1.06). The percentage of adolescents screening positive for depressive symptoms increased from 5.0% to 6.2% (PR: 1.24, 95% CI: 1.15–1.34), with greater increases among female, non-Hispanic Black, and non-Hispanic white adolescents. Positive suicide risk screens increased from 6.1% to 7.1% (PR: 1.16, 95% CI: 1.08–1.26), with a 34% relative increase in reporting recent suicidal thoughts among female adolescents (PR: 1.34, 95% CI: 1.18–1.52).CONCLUSIONSResults suggest that depression and suicide concerns have increased during the pandemic, especially among female adolescents. Results underscore the importance of consistent depression and suicidality screening.
Learning Continuity during COVID-19 Pandemic using the Virtual Classroom – A Cross-border experimental Multi Case Approach
Authors: Hasan Khandakar Kamrul , Mukherjee Debarshi , Saha Mahasweta 
Published: June 2021

Aim. The global pandemic of the COVID-19 outbreak and the subsequent nationwide lockdown have put the endeavours of both academicians and students to the test. The disruptions are even visible in andragogical approaches across higher education institutions both nationally and internationally. Two government-funded universities in India and Bangladesh have decided to explore avenues to switch to an alternative e-platform overcoming the challenges of traditional classroom teaching. The business management faculties of both universities exercise blended learning modules using a design thinking approach.
Methods. This exploratory case study involves university students and teachers reflecting the knowledge delivery mechanism in a collaborative online workspace called Virtual Classroom. The authors have adopted the case method to identify evidence-based practices to improve learning gain. This case is motivated by the profound idea of learning continuity where the agenda of teaching-learning should remain status quo as much as possible, even under the constrained situation.
Results and Conclusion. This study confirms that the use of curriculum-based blended learning modules based on a design thinking approach is gaining momentum to offer courses in which videoconferencing is a useful tool, as an addition to present methods of teaching inside the classroom, to strengthen learning and to inspire students to practice learning. Acceptance of technology has made learning accessible and pervasive, bridging the digital divide.
Originality. It is a pioneering effort to measure the effectiveness of the online learning of two public-funded universities across borders with similar demographics and challenges. This case makes an original contribution through its observation that even the traditional and public-funded universities erstwhile functioning through purely offline mode are gradually switching to online mode. This case also highlights the imminent need for policymakers to augment and integrate blended learning tools with design thinking approaches for tertiary education to reduce the intermittent use of technology, thereby assuring higher learning gain for the students.
Instabilities in liquid crystal elastomers
Authors: Mihai L. Angela , Goriely Alain 
Published: June 2021

AbstractStability is an important and fruitful avenue of research for liquid crystal elastomers. At constant temperature, upon stretching, the homogeneous state of a nematic body becomes unstable, and alternating shear stripes develop at very low stress. Moreover, these materials can experience classical mechanical effects, such as necking, void nucleation and cavitation, and inflation instability, which are inherited from their polymeric network. We investigate the following two problems: First, how do instabilities in nematic bodies change from those found in purely elastic solids? Second, how are these phenomena modified if the material constants fluctuate? To answer these questions, we present a systematic study of instabilities occurring in nematic liquid crystal elastomers, and examine the contribution of the nematic component and of fluctuating model parameters that follow probability laws. This combined analysis may lead to more realistic estimations of subsequent mechanical damage in nematic solid materials. Because of their complex material responses in the presence of external stimuli, liquid crystal elastomers have many potential applications in science, manufacturing, and medical research. The modeling of these materials requires a multiphysics approach, linking traditional continuum mechanics with liquid crystal theory, and has led to the discovery of intriguing mechanical effects. An important problem for both applications and our fundamental understanding of nematic elastomers is their instability under large strains, as this can be harnessed for actuation, sensing, or patterning. The goal is then to identify parameter values at which a bifurcation emerges, and how these values change with external stimuli, such as temperature or loads. However, constitutive parameters of real manufactured materials have an inherent variation that should also be taken into account, thus the need to quantify uncertainties in physical responses, which can be done by combining the classical field theories with stochastic methods that enable the propagation of uncertainties from input data to output quantities of interest. The present study demonstrates how to characterize instabilities found in nematic liquid crystal elastomers with probabilistic material parameters at the macroscopic scale, and paves the way for a systematic theoretical and experimental study of these fascinating materials.
Conducting materials as building blocks for electronic textiles
Authors: Lund Anja , Wu Yunyun , Fenech-Salerno Benji , Torrisi Felice , Carmichael Tricia Breen , Müller Christian 
Published: June 2021

Abstract
To realize the full gamut of functions that are envisaged for electronic textiles (e-textiles) a range of semiconducting, conducting and electrochemically active materials are needed. This article will discuss how metals, conducting polymers, carbon nanotubes, and two-dimensional (2D) materials, including graphene and MXenes, can be used in concert to create e-textile materials, from fibers and yarns to patterned fabrics. Many of the most promising architectures utilize several classes of materials (e.g., elastic fibers composed of a conducting material and a stretchable polymer, or textile devices constructed with conducting polymers or 2D materials and metal electrodes). While an increasing number of materials and devices display a promising degree of wash and wear resistance, sustainability aspects of e-textiles will require greater attention.

Graphical abstract
PRIMARY ASSESSMENT OF THE DEGREE OF TORREFACTION OF BIOMASS AGRICULTURAL CROPS
Authors: Yermakov Serhii , Hutsol Taras , Glowacki Szymon , Hulevskyi Vadym , Pylypenko Viktoriia 
Published: June 2021

Biomass energy is an important component in the overall structure of renewable energy and has the greatest potential for increasing volumes. However, the peculiarities of the properties of agro-industrial residues are a significant disadvantage of their widespread use. The process of torrefaction allows to bring the characteristics of biofuel as close as possible to thermal coal. Different degree of heat treatment of biomass leads to a product with different heating value. Therefore, it is important to know the optimal mode of torrefaction, which will provide the best energy parameters of biofuels.Researches of torrefaction were carried out on the basis of educational and scientific laboratory "DAK GPS" of the State Agrarian and Engineering University in Podilia. The kinetics of the relative mass of different types of biomass at different processing temperatures was considered. The dependence of the degree of torrefaction on the heat treatment temperature is revealed. As shown by studies for most biomaterials of plant origin, we can distinguish the beginning of intensive transformation and its end, after which there is a sharp slowdown in weight loss, and, accordingly, and the energy density of the samples.
COMSOL SIMULATION OF LASER WELDING OF ALUMINUM
Authors: Balchev Ivaylo , Lazov Lyubomir , Angelov Nikolaj , Teirumnieka Erika 
Published: June 2021

This research includes a Comsol Mutiphysics model describing the temperature distribution on aluminum during the laser conductivity welding process. The influence of laser power and speed on the welding process is discussed and compared with experiments. Numerical simulations of laser welding process have been performed to determine the temperature fields of laser impact to samples of aluminum. Numerical calculations are made for fiber laser. The plots of the temperature dependence on the surface and in the depth of aluminum samples on the velocity are analyzed for several power densities for this laser.
Diagnostic efficiency of the main dermatoscopic symptoms and algorithms for detecting skin melanoma
Authors: Mamunov Maksim V. , Patrushev Aleksandr V. 
Published: June 2021

AIM: to assess the diagnostic accuracy of the main dermatoscopic signs and algorithms used to diagnose skin melanoma.
MATERIALS AND METHODS: To assess the diagnostic effectiveness of the performed dermatoscopy in detecting skin melanoma, the main dermatoscopic signs that occur in this disease were identified: atypical pigment network, atypical globules, asymmetry of pigmentation and structure, asymmetric stripes, asymmetric zones of hyperpigmentation (spots), blue-white (white-blue) veil, graininess, scar-like foci of depigmentation, white shiny stripes, negative pigment network. The study was carried out based on the analysis of 34 archival dermatoscopic images of melanocytic skin lesions with a morphologically verified diagnosis (11 melanomas and 23 melanocytic nevi). In addition, a comparison was made of the indicators of the diagnostic efficiency of two main dermatoscopic algorithms used in the diagnosis of skin melanoma: the algorithm by 3 signs and by 7 signs. For this, 186 archived dermatoscopic images of melanocytic skin lesions were analyzed. All patients included in the study were examined and treated at the clinic for skin and venereal diseases in the period from 2015 to 2019. The study was carried out using a HEINE DELTA 20 Plus dermatoscope in immersion mode and in cross-polarization.
RESULTS: The following dermatoscopic features had the highest diagnostic efficiency for the diagnosis of skin melanoma: blue-white veil (86.8%), asymmetry of pigmentation and structure (82.6%), and white shiny stripes (72.8%). The diagnostic efficiency of the 3 signs algorithm was 93.0%, the 7 signs algorithm 90.5%.
CONCLUSION: Diagnostic algorithms for confirming melanoma can be successfully used by both general practitioners and medical specialists (dermatologists, oncologists). In this case, it is preferable to use the three signs algorithm at the initial admission of patients as a screening option, and the seven-signs algorithm by experienced specialists in the field of dermatoscopy to confirm the diagnosis (4 figures, 3 tables, bibliography: 11 refs).
On the features of the preperitoneal space multifascial structure in clinical and anatomical issues
Authors: Boytsova Yuliуa A. , Fomin Nikolay F. , Shvedyuk Viktor V. 
Published: June 2021

AIM: to determine the prospects for the preventive endoprosthetics of the abdominal wall at preventing the development of postoperative ventral hernias.
MATERIALS AND METHODS: A meta-analysis of the literature data performed to determine the effectiveness of preventive endoprosthetics for the prevention of ventral hernia formation. Topographical study has been conducted to explore the most promising levels of the mesh location.
RESULTS: During the meta-analysis it has been found that performing preventive endoprosthesis of the anterior abdominal wall t in the preperitoneal space reduces the frequency of ventral hernias. There were no significant differences in the frequency of infectious complications and serom in the experimental and control groups according to studied publications. During the preparation it has been distinguished that between the transverse fascia and the peritoneum there is a preperitoneal fascia consisting of two leaves, which is most manifest in the lateral parts. In the umbilical region above linea arcuata the preperitoneal fascia is thinned and represented by separate fibers that are difficult to differentiate as a structure between the transverse fascia and the peritoneum. In the lateral parts of the abdominal wall, the preperitoneal fascia is well expressed. It has been distinguished that the retroperitoneal fascia, formed by the junction of two sheets of the Gerot fascia continues into the fascia between the transverse fascia and the peritoneum.
CONCLUSION: Preventive endoprosthesis of the anterior abdominal wall is an effective and safe method of preventing the formation of postoperative ventral hernias. The anterior abdominal wall is characterized by a complex multifascial structure, which is of fundamental importance for various types of surgery. Between the transverse fascia and the peritoneum there is preperitoneal fascia which is represented by two leaflets. Its continuation is the retroperitoneal fascia (5 figures, 2 tables, bibliography: 8 refs).
Centrifuge Studies of Topographic Effects: Parametric Investigation
Authors: Dafni Jacob , Wartman Joseph 
Published: June 2021

ABSTRACTThis article presents the results of a comprehensive geotechnical centrifuge experimental program to investigate topographic effects across a series of single-sided slopes. The experimental campaign considered a range of governing factors, including slope inclination and ground-motion amplitude, frequency content, and duration. The testing program was nondestructive, allowing the centrifuge models to be subjected to over 140 different ground motions. Clear evidence of topographic effects, including amplification and deamplification of ground motion, were observed. Topography modified the frequency content and amplitude of the ground motion such that at the slope crest (1) peak ground accelerations ranged from 50% less than to 200% greater than the free-field, and (2) ground-motion mean square frequency shifted by as much as 55%. Higher topographic amplification levels lead to a larger topographic zone of influence, which, on average, spanned a distance equal to the slope height (H) behind and 2H in front of (toward slope) the slope crest. Physical modeling in the centrifuge proved to be a powerful experimental technique for generating empirical data to analyze topographic effects in a systematic and repeatable manner.
Dissolution and Separation of Marriage and Their Effects as Envisaged by Drafts of Marriage Law in Interwar Poland
Authors: Dworas-Kulik Judyta 
Published: June 2021

Rozwiązanie i rozłączenie małżeństwa oraz ich skutki w projektach prawa małżeńskiego w Drugiej Rzeczypospolitej
Istotą małżeństwa była stałość wspólnego pożycia małżeńskiego mająca na celu wzajemną pomoc oraz zrodzenie i wychowywanie dzieci. Podzielone społeczeństwo Drugiej Rzeczypospolitej toczyło spory wokół charakteru prawa małżeńskiego, przez co nie doszło do ujednolicenia tej gałęzi prawa w okresie międzywojennym. Konsekwencje na gruncie prawa cywilnego wywołane międzywojenną mozaiką prawną były odczuwane jeszcze w okresie Polski Ludowej. Projekt Komisji Kodyfikacyjnej ogłoszony publicznie i poddawany opinii społecznej w postaci ankiet oraz publicznych dyskusji został skrytykowany przez środowisko konserwatywne. Dwóch przedstawicieli tegoż środowiska przygotowało swoje projekty prawa małżeńskiego. Byli nimi Zygmunt Liskowski, którego projekt prawa małżeńskiego oparty na systemie wyznaniowym poparł Episkopat oraz projekt księdza Jerzego Jaglarza w dużej mierze powielający rozwiązania prawne zawarte w projekcie Karola Lutostańskiego. Z uwagi na to, że celem niniejszego artykułu jest przedstawienie instytucji rozwodu i separacji oraz ich skutków w powyższych projektach prawa małżeńskiego okresu międzywojennego, zastosowano tu przede wszystkim metodę historyczno-prawną oraz komparatystyczną.
Dopuszczenie dowodu z opinii innego biegłego w polskim postępowaniu cywilnym i karnym. Podobieństwa i różnice
Authors: Kłak Czesław Paweł 
Published: June 2021

Artykuł dotyczy problematyki dopuszczenia dowodu z opinii innego biegłego w świetle kodeksu postępowania cywilnego i kodeksu postępowania karnego. W postępowaniu cywilnym nie określono przesłanek zasięgnięcia opinii innego biegłego, podczas gdy w postępowaniu karnym wyraźnie określono, kiedy dopuszczalne jest podjęcie takiej decyzji. Mimo tego, w orzecznictwie Sądu Najwyższego zasadnie przyjęto, że sąd w postępowaniu cywilnym nie ma dowolności w powoływaniu kolejnych biegłych, a u podstaw takiej decyzji leżeć powinny racjonalne argumenty, takie jak np.: niejasność, niezupełność czy sprzeczności występujące w opiniach. Zarówno na gruncie kodeksu postępowania cywilnego, jak i na gruncie kodeksu postępowania karnego, nie ulega wątpliwości, że dopuszczenie dowodu z opinii innego biegłego nie jest dopuszczalne tylko i wyłącznie dlatego, że opinia nie przekonuje strony czy też jest dla niej niekorzystna. Dopuszczenie dowodu z opinii kolejnego biegłego jest w takim przypadku niedopuszczalne, nie znajduje bowiem żadnej podstawy normatywnej. Zdaniem Autora, przepisy proceduralne w jednakowy sposób powinny regulować kwestię dopuszczenia dowodu z opinii innego biegłego, nie ma bowiem żadnego uzasadnienia, aby inne rozwiązania obowiązywały w postępowaniu cywilnym, a inne w postępowaniu karnym. Z przepisów powinno w sposób jednoznaczny wynikać, kiedy możliwe jest dopuszczenie dowodu z opinii innego biegłego, tj. jakie są przesłanki podjęcia takiej decyzji, jak również w jakim następuje to trybie. W tej materii rozwiązanie przyjęte w kodeksie postępowania karnego jest bardziej precyzyjne, zaś przepisy kodeksu postępowania cywilnego mają charakter zbyt ogólny.
New space (nowa era działalności w Kosmosie) – problemy prawne i gospodarcze oraz kwestie bezpieczeństwa
Authors: Polkowska Małgorzata 
Published: June 2021

New Space (nowa era działalności w Kosmosie) oznacza ewolucyjny proces od ery komercjalizacji i prywatyzacji, którą charakteryzowały kontrakty rządowe (gdzie rząd działał jako najemca i nabywca sprzętu) do ery komercyjnej, gdzie rząd i firmy prywatne nabywają usługi z sektora prywatnego. Stała komercjalizacja wymaga dostosowania istniejącego prawodawstwa do aktualnych potrzeb i wyzwań. Istnieje ponadto potrzeba wspólnego zrozumienia zasad swobody dostępu do przestrzeni kosmicznej oraz potrzeba jej globalnego rozwoju.
Obowiązki nałożone w art. VI układu kosmicznego (OST) z 1967 r., dotyczące autoryzacji i stałego nadzoru, są w gestii państw. Kwestia związana z jurysdykcją staje się dotkliwa dla podmiotów prywatnych, kiedy ta wolność zostaje transponowana na poziom narodowy i prywatny. Koncepcja odpowiedzialności za działalność niezgodną z zasadami prawa międzynarodowego, w tym działalność podmiotów prywatnych, i odpowiedzialność państwa za szkody wyrządzone przez obiekty kosmiczne, w tym przez prywatnych operatorów, staje się najbardziej fundamentalną kwestią międzynarodowego prawa kosmicznego z perspektywy prywatyzacji działalności kosmicznej.
Państwa są więc zmuszane do podjęcia wewnętrznych działań, do monitorowania i kontroli działalności prywatnej przedsiębiorców. Współdziałanie międzynarodowej i krajowej legislacji jest konieczne w obliczu prywatyzacji działalności kosmicznej. Państwa kontrolują prywatne przedsiębiorstwa, mają mechanizmy legislacyjne potrzebne do ustalenia reżimu licencjonowania i monitoringu oraz system sankcji.
Wyzwania gospodarcze i te związane z bezpieczeństwem, przedstawione w pracach nad działalnością kosmiczną w „nowej erze działalności w kosmosie” i z nimi związane ograniczenia i problemy pokazują, jak ważna jest pokojowa współpraca między państwami.