bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of respiratory syncytial virus infectivity by Ephedrae Herba and Cinnamomi Cortex through interaction with G glycoprotein
Authors: Fujikane Aya , Sakamoto Atsuhiko , Fujikane Ryosuke , Nishi Akinori , Ishino Yoshizumi , Hiromatsu Kenji , Nabeshima Shigeki 
Published: March 2021

Abstract
Although respiratory syncytial virus (RSV) is a major cause of respiratory tract infection in children, no effective therapies are available. Recently, RSV G, the attachment glycoprotein, has become a major focus in the development of therapeutic strategies against RSV infection. Treatment of RSV-infected cultured cells with maoto, a traditional herbal medicine for acute febrile diseases, significantly reduced the viral RNA and titers. RSV attachment to the cell surface was inhibited both in the presence of maoto and when RSV particles were pre-treated with maoto. We demonstrated that maoto components, Ephedrae Herba (EH) and Cinnamomi Cortex (CC), specifically interacted with the central conserved domain (CCD) of G protein, and also found that this interaction blocked viral attachment to the cellular receptor CX3CR1. Genetic mutation of CX3C motif on the CCD, the epitope for CX3CR1, decreased the binding capacity to EH and CC, suggesting that CX3C motif was the target for EH and CC. Finally, oral administration of maoto for five days to RSV-infected mice significantly reduced the lung viral titers. These experiments clearly showed the anti-RSV activity of EH and CC mixed in maoto. Taken together, this study provides new insights for the rational design of therapies against RSV infection.
Multifunctional Antiferromagnetic Materialswith Giant Piezomagnetism and Noncollinear Spin Current
Authors: Ma Hai-Yang , Hu Mengli , Li Nana , Liu Jianpeng , Yao Wang , Jia Jinfeng , Liu Junwei 
Published: March 2021

Abstract
We propose a new type of spin-valley locking (SVL), named C-paired SVL, in antiferromagnetic systems, which directly connects the spin/valley space with the real space, and hence enables both static and dynamical controls of spin and valley to realize a multifunctional antiferromagnetic material. The new emergent quantum degree of freedom in the C-paired SVL is comprised of spin-polarized valleys related by a crystal symmetry instead of the time-reversal symmetry. Thus, both spin and valley can be accessed by simply breaking the corresponding crystal symmetry. Typically, one can use a strain field to induce a large net valley polarization/magnetization and use a charge current to generate a large noncollinear spin current. We predict the realization of the C-paired SVL in monolayer V2Se2O, which indeed exhibits giant piezomagnetism and can generate a large transverse spin current. Our findings provide unprecedented opportunities to integrate various controls of spin and valley with nonvolatile information storage in a single material, which is highly desirable for versatile fundamental research and device applications.
Future Directions on Low-Energy Radiation Dosimetry
Authors: Massillon-JL G 
Published: March 2021

Abstract
For more than one century, low-energy (< 100 keV) photons (x-rays and gamma) have been widely used in different areas including biomedical research and medical applications such as mammography, fluoroscopy, general radiography, computed tomography, and brachytherapy treatment, amongst others. It has been demonstrated that most of the electrons produced by low photon energy beams have energies below 10 keV. However, the physical processes by which these low energy electrons interact with matter are not yet well understood. Besides, it is generally assumed that all the energy deposited within a dosimeter sensitive volume is transformed into a response. But such an assumption could be incorrect since part of the energy deposited might be used to create defects or damages at the molecular and atomic level. Consequently, the relationship between absorbed dose and dosimeter response can be mistaken. During the last few years, efforts have been made to identify models that allow to understand these interaction processes from a quantum mechanical point of view. Some approaches are based on electron-beam − solid-state-interaction models to calculate electron scattering cross-sections while others consider the density functional theory method to localize low energy electrons and evaluate the energy loss due to the creations of defects and damages in matter. The results obtained so far could be considered as a starting point. This paper presents some methodologies based on fundamental quantum mechanics which can be considered useful for dealing with low-energy interactions.
Enhancement of the Antifungal Properties of Zataria Multiflora Essential Oil Thorough Combination With Zno Nanomaterial
Authors: Enayati Samira , Davari Mahdi , Habibi-Yangjeh Aziz , Ebadollahi Asgar , Feizpoor Solmaz 
Published: March 2021

Abstract
Fusarium is one of the most important and destructive phytopathogenic fungi on a wide range of host plants. In the present study, to achieve a suitable alternative for high-risk synthetic chemicals, the antifungal effects of ZnO and ZnO-EO (Zataria multiflora Boiss essential oil loaded on ZnO) materials were investigated against six isolates of Fusarium. The chemical composition of Z. multiflora essential oil (EO) was explored by GC-MS, in which thymol and carvacrol were the main components. The physio-chemical properties of fabricated materials were studied by SEM, BET, FT-IR, TGA, EDX, XRD, and DLS analyses. The mycelial growth inhibitory (MGI) of ZnO and ZnO-EO materials were tested against Fusarium oxysporum f.sp. lycopersici, F. oxysporum f.sp. lentis, F. graminearum, F. graminearum, F. verticillioides, and F. brasilicum in the laboratory conditions. The results showed that ZnO-EO nanocomposite had a fungistatic effect against all tested fungi except F. oxysporum f.sp. lentis and the fungicidal activity against F. graminearum at a concentration of 1000 ppm. The MGI of ZnO-EO nanocomposite was increased by 42.70% compared to the pure ZnO and by 66.33% compared to Z. multiflora EO. The MGI of pure ZnO compared to Z. multiflora EO was also increased by 23.63%. According to the current findings, the ZnO-EO nanocomposite can be considered as a bio-rational efficient alternative to conventional chemical fungicides.
Efficacy of Mhealth Interventions to Improve Nasal Corticosteroid Adherence in Allergic Rhinitis: A Systematic Review Protocol
Authors: Baxter Mats , Schwarze Jurgen , Bush Andrew , Sheikh Aziz 
Published: March 2021

Abstract
IntroductionMobile health (mHealth) is a potential tool to improve nasal corticosteroid (NCS) adherence in allergic rhinitis (AR), which remains largely poor and inconsistent for many. We plan to undertake a systematic review to synthesise the evidence on the efficacy of mHealth interventions to improve NCS adherence in AR. Methods and analysisA systematic search will be conducted in the electronic databases MEDLINE, EMBASE and CENTRAL (Cochrane Central Register of Controlled Trials), filtered for publication dates between January 2010 and August 2020. The search is scheduled to commence in August 2020. We will scan reference lists of included studies for additional eligible papers. Relevant unpublished or in-progress trials will be searched for through trial registries. Randomised controlled trials that examine the efficacy of mHealth interventions to improve NCS adherence in AR are to be included. Two reviewers will independently screen and extract relevant data from the included studies and perform a risk-of-bias assessment using the Cochrane risk of bias tool 2.0. We will perform a narrative synthesis with relevant data tables and, if deemed clinically relevant and statistically adequate, meta-analyses using random-effects modelling. The Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) statement will be used to help guide the reporting of this review. Ethics and disseminationSince this systematic review will be exclusively based on published and retrievable literature, no ethics approval will be sought. The findings of this systematic review will be disseminated at appropriate conferences/webinars while being published in an open access peer-reviewed journal.Registration: In accordance with the guidelines, our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 27th August 2020. PROSPERO registration number CRD42020198879.
A Novel Peripheral Whole Blood hsa_circ_0005430&nbsp;is a Potential Biomarker for Lung Adenocarcinoma
Authors: Mu YINYU , Xie Fuyi , Ye Chunxia , Yang Dongdong 
Published: March 2021

Abstract
Background: This study was aimed to determine the circular RNA 5430(hsa_circ_0005430) in peripheral whole blood（PWB）from lung adenocarcinoma (LA) patients is a novel biomarker for screening LA.Methods: The expression levels of hsa_circ_0005430 in PWB from 20 LA patients and 10 healthy controls were performed using real-time quantitative reverse transcription-polymerase chain reaction(RT-qPCR). Serum CEA, CA199 and CA50 were detected by chemiluminescent immunoassay. Spearman’ correlation test was used to evaluate the correlation of hsa_circ_0005430 and clinical variables. The receiver operating characteristic (ROC) curve was established to evaluate its diagnostic value. Results: PWB hsa_circ_0005430 was significantly elevated in LA patients, comparing with healthy controls. There was no significant difference in hsa_circ_0005430 level among different pathological factors of LA. In these LA patients, we found a significant correlation between PWB hsa_circ_0005430 and disease activity, including carcinoembryonic antigen(CEA), carbohydrate antigen 199(CA199) and carbohydrate antigen 50 (CA50). ROC analysis showed that PWB hsa_circ_0005430 had an area under the curve(AUC) of 0.75 (95% CI 0.567-0.928, P< 0.001) to discriminate LA patients from controls with sensitivity of 0.900 and specificity of 0.65. The highest Youden index was 0.55 and the corresponding optimal cut-off value was 0.14. Conclusions: This study revealed that PWB hsa_circ_0005430 in LA may serve as a potential biomarker for LA patients diagnosis.
Neurodevelopmental Disorder traits in&nbsp;Taijin-Kyofu-Sho&nbsp;and Social Anxiety Disorder: A Cross-Sectional Study Among University Students
Authors: Kajitani Kosuke , Tsuchimoto Rikako , Omodaka Yusaku , Matsushita Tomoko , Fukumori Hideaki , Sato Takeshi , Nagano Jun 
Published: March 2021

Abstract
Background: Taijin-Kyofu-sho, an East Asian culture-bound anxiety disorder, has been likened to social anxiety disorder. However, few studies have examined these two disorders from the perspective of neurodevelopmental disorders. This study aimed to examine the association of Taijin-Kyofu-sho and social anxiety disorder with attention-deficit/hyperactivity disorder and autism spectrum disorder.Methods: The Liebowitz Social Anxiety, Taijin-Kyofu-sho, and Adult Attention-Deficit/Hyperactivity Disorder Self-Report scales and the 16-item Autism-Spectrum Quotient were administered to 818 university students. Participants were divided into four groups: control (neither Taijin-Kyofu-sho ­­nor social anxiety disorder), pure Taijin-Kyofu-sho (Taijin-Kyofu-sho alone), pure social anxiety disorder (social anxiety disorder alone), and Taijin-Kyofu-sho-social anxiety disorder mixed (both Taijin-Kyofu-sho ­­and social anxiety disorder). We used logistic regression analysis to examine whether attention-deficit/hyperactivity disorder and autism spectrum disorder were associated with Taijin-Kyofu-sho and social anxiety disorder.Results: Autism spectrum disorder was significantly associated with pure Taijin-Kyofu-sho (p = 0.006, odds ratio: 3.99). Female sex and attention-deficit/hyperactivity disorder were significantly associated with pure social anxiety disorder (sex: p = 0.013, odds ratio: 2.61; attention-deficit/hyperactivity disorder: p = 0.012, odds ratio: 2.46). Female sex, attention-deficit/hyperactivity disorder, and autism spectrum disorder were significantly associated with Taijin-Kyofu-sho-social anxiety disorder mixed (sex: p = 0.043, odds ratio: 2.16; attention-deficit/hyperactivity disorder: p = 0.003, odds ratio: 2.75; autism spectrum disorder: p < 0.001, odds ratio: 16.93). Conclusions: Neurodevelopmental disorder traits differed between individuals with Taijin-Kyofu-sho and those with social anxiety disorder. Japanese individuals with attention-deficit/hyperactivity disorder or autism spectrum disorder traits are at a risk of developing Taijin-Kyofu-sho or social anxiety disorder in the future.
Primary Tumor Location is Associated with Prognosis for Women with Breast Cancer
Authors: Tang Zhuowei , Ji Yuzhu , Zhang Xiaohong , Xu Weiyun , Zhao Lijuan , Zhang Jing , Long Li , Feng Jing , Wen Yixue 
Published: March 2021

Abstract
Background: The prognostic impact of tumor location on breast cancer patients is not consistent and still controversial. We aimed to investigate the prognostic role of primary tumor location on the survival of patients with breast cancer. Methods: Using the Surveillance, Epidemiology, and End Results database, we identified 53,905 patients diagnosed with tumors in the lower quadrants (n=11,065), upper quadrants (n=38,974), or central and nipple (n=3,866). Chi-squared test was used to compare categorical variables across the groups. Cox proportional hazard models were applied to estimate the factors associated with prognosis.Results: Compared with the other quadrants, patients with central and nipple lesions showed generally more unfavorable clinicopathologic features and worse breast cancer-specific survival (BCSS) and overall survival (OS). Multivariate Cox analysis showed a higher hazard ratio (HR) for tumor location of central and nipple (BCSS: HR, 1.145, p = 0.036, 95% confidence interval [CI], 1.009-1.299; OS: HR, 1.118, p = 0.024, 95% CI: 1.015-1.232), while lower HR were observed for upper quadrants (BCSS: HR, 0.888, p = 0.004, 95% CI: 0.818-0.964; OS: HR, 0.930, p = 0.023, 95% CI: 0.873-0.990). Multivariate logistic regression indicated that tumors located in central and nipple were more likely to be inoperable disease (HR, 1.460, 95% CI: 1.300-1.640, p < 0.001), while tumors located in upper quadrants tend to be operable disease (HR, 0.895, p = 0.005, 95% CI, 0.829-0.967).Conclusion: Tumors located in central and nipple had negative contact with BCSS and OS, while tumor located in upper quadrants had favorable contact with survival.
Measuring SHmax with Stress-Induced Anisotropy in Nonlinear Anelastic Behavior
Authors: Delorey Andrew , Bokelmann Götz , Johnson Christopher , Johnson Paul 
Published: March 2021

Abstract
Mechanical stress acting in the Earth`s crust is a fundamental property that has a wide range of geophysical applications, from tectonic movements to energy production. The orientation of maximum horizontal compressive stress, SHmax can be estimated by inverting earthquake source mechanisms and directly from borehole-based measurements, but large regions of the continents have few or no observations. Available observations often represent a variety of length scales and depths, and can be difficult to reconcile. Here we present a new approach to determine SHmax by measuring stress induced anisotropy of nonlinear susceptibility. We observe that nonlinear susceptibility is azimuthally dependent in the Earth and maximum when parallel to SHmax, as predicted by laboratory experiments. Our measurements use empirical Green’s functions that are applicable for different temporal and spatial scales. The method can quantify the orientation of SHmax in regions where no measurements exist today.
Latent tri-lineage potential of human menstrual blood-derived mesenchymal stromal cells revealed by specific in vitro culture conditions
Authors: Quintero-Espinosa Diana , Soto-Mercado Viviana , Quintero-Quinchia Catherine , Mendivil-Perez Miguel , Velez-Pardo Carlos , Jimenez-Del-Rio Marlene 
Published: March 2021

Abstract
Human menstrual blood-derived mesenchymal stromal cells (MenSCs) have become not only an important source of stromal cells for cell therapy but also a cellular source for neurologic disorders in vitro modeling. By using culture protocols originally developed in our laboratory, we show that MenSCs can be converted into floating neurospheres (NSs) using the Fast-N-Spheres medium for 24-72h, and can be transdifferentiated into functional dopaminergic-like (DALNs, ~26% TH+/DAT+ flow cytometry) and cholinergic-like neurons (ChLNs, ~46% ChAT+/VAChT flow cytometry) which responded to dopamine- and acetylcholine- triggered neuronal Ca 2+ inward stimuli when cultured with the NeuroForsk and the Cholinergic-N-Run medium , respectively in a timely fashion (i.e., 4-7 days). Here, we also report a direct transdifferentiation method to induce MenSCs into functional astrocyte-like cells (ALCs) by incubation of MenSCs in commercial Gibco® Astrocyte Medium in 7-days. The MSCs-derived ALCs (~59% GFAP+/S100b+) were found to respond to glutamate-induced Ca 2+ inward stimuli. Altogether these results show that MenSCs are a reliable source to obtain functional neurogenic cells to further investigate the neurobiology of neurologic disorders.
Effect of particle size on rotary drum composting of garden waste and their ranking using analytical hierarchy process
Authors: Mishra Sandeep , Yadav Kunwar D 
Published: March 2021

Abstract
Garden waste comprises of 15–18% fraction of total municipal solid waste generated. For composting of garden waste, particle size is an important factor for efficient degradation. The present study investigates role of varying particle size on compost quality. The garden waste was grinded using a shredder into varying size of particles, 0.5–1.5, 1.5-3.0, 3.0-4.5 and 4.5–7.5 cm diameter named as R1, R2, R3 and R4 respectively. 100 kg of garden waste mixed with 20 litre cow-dung slurry and 10 kg fresh compost and feed into the rotary drum for 45 days composting period. Thermophilic phase continued for 7, 8, 4 and 3 days in R1, R2, R3 and R4 reactor respectively. Total volatile solids reduction was 29.10, 31.20, 24.23 and 17.12 %, CO2 evolution rate was 4.92, 4.14, 6.18 and 8.16 mg/gVS/d, C/N ratio was 16.91, 15.05, 18.13 and 20.99, germination index was 92.00, 94.12, 85.21 and 81.20 in R1, R2, R3 and R4 reactor respectively after end of composting period. Reduction of hemicellulose, cellulose, and lignin was highest in R2 drum and lowest in R4. The percentage reduction of acid insoluble lignin was 36, 39, 29 and 27 % and the percentage reduction of acid soluble lignin was 48.85, 52.89, 43.39 and 36.97 % in combinations in R1, R2, R3 and R4 respectively after 45 days. As per analytical hierarchy process, performance of reactors was observed in the following trend, R2 > R1 > R3 > R4. Particle size range 1.5-3.0 cm diameter showed optimum size for efficient composting of garden waste.
A simplified version of TI-RADS exhibits comparable diagnostic performance in malignancy risk stratification of thyroid nodules
Authors: Chen Qingfang , Wu Size 
Published: March 2021

Abstract
Evaluation of thyroid focal lesions using thyroid imaging reporting and data system (TIRADS) has been proceeding for a decade, but there is no consensus on any version of TIRADS. The purpose of this study was to validate a recently launched simplified Chinese version of TIRADS, with a compare to the American College of Radiology version of TIRADS. A total of 1306 patients with 1389 thyroid nodules were reviewed and assessed according the two TIRADSs, and the histopathological results were taken as golden standard. The results showed there were 973 benign nodules and 416 malignant nodules. The highest accuracies(AUCs)of C-TIRADS 4C and ACR-TIRADS 5 were taken as the optimized cut-off values for diagnosis. The sensitivity, specificity, PPV, NPV and AUC by C-TIRADS 4C and ACR-TIRADS 5 for thyroid nodule evaluation were 87.39%, 89.92%, 75.00%, 95.38% and 0.89, and 85.58%, 91.88%, 81.84%, 93.71% and 0.89, respectively, (P > 0.05 for all). We concluded that C-TIRADS and ACT-TIRADS have very good diagnostic performance in differentiating malignant from benign thyroid nodules by each optimized cut-off value, and the diagnostic performance of the fewer parameters based C-TIRADS 4C is comparable to the multiple parameters based ACR-TIRADS 5.
Ethno-pharmacological use of Ethiopian indigenous forest honey: the case of Sheka forest&nbsp;
Authors: Tilahun Minyahel , Alemu Tena , Mengistu Shimelis , Ayalew Wondessen , Hailu Abera 
Published: March 2021

Abstract
Background

Sheka forest is the last indigenous forest in Ethiopia. Plant species are important for the production of different honey types used for both consumption and healing purpose. Healing purposes of plant species used for honey production has not been well documented. Documentation of the community honey based ethno pharmacological knowledge can provide huge significance in the process of subjective interpretation.
Materials and Methods

The study employed ethnographic descriptive and explanatory research design which participate 40 healers from Sheka forest, Ethiopia Quantitative analytical tools such as relative frequency citation (RFC), use value (UV), cultural importance index (CI), relative importance (RI), frequency index (FI) and informants consensus factor (ICF).
Results

Six major plant species have been identified in the study area. Honey made from Scheflera abyssinica (Geteme) had higher relative importance (1.67), relative frequency citations (0.55), citation index and frequency index (100). Honey from Vernonia amygdaline (Girawa) was used basically to treat human ailments such as diarrhea and Tonsillitis. Honey from Ficus vasta (Sholla) was primarily used to treat coughing, itching and allergy. Syzgiu guineense (Dokima) and Guizotia schimperi (Meskel Abeba) honeys were primarily used as cosmetics and to protect skin from excessive cold. Scheflera abyssinica honey was used for treat of almost all of the above listed ailments. Ailments like cosmetics and excessive cold, Tonsillitis and Itching and Allergy had a higher Informant Consensus Factor (ICF) of 0.86, 22 0.82 and 0.80, respectively. Wound and Foot and Mouth diseases were the only two livestock ailments treated by five different honey types.
Conclusion

Six plant species used for medicinal honey production that treated eight ailments have been identified. Scheflera abyssinica (Geteme) honey used for the treatment of eight human ailments. Honey treatment for Tonsillitis and itching and allergy had a higher Informant Consensus Factor.