bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the validity of an IAU General English Achievement Test through hybridizing differential item functioning and differential distractor functioning
Authors: Jamalzadeh Mehri , Lotfi Ahmad Reza , Rostami Masoud 
Published: June 2021

AbstractThe current study sought to examine the validity of a General English Achievement Test (GEAT), administered to university students in the fall semester of 2018–2019 academic year, by hybridizing differential information (DIF) and differential distractor function (DDF) analytical models. Using a purposive sampling method, from the target population of undergraduate students studying in different disciplines at Islamic Azad University (IAU), (Isfahan branch), a sample of 835 students taking GEAT were selected. The 60-item multiple-choice test comprised four sub-sections; namely, vocabulary, grammar, cloze test, and reading comprehension. The students’ test scores served as the targeted data and the validity of the test was examined through the application of Cochran-Mantel-Haenszel (CMH) and multinomial log-linear regression models for detecting DIF and DDF, respectively. To account for the assumption of uni-dimensionality, the test sub-sections were analyzed independently. Furthermore, the assumption of local independence was checked based on correlational analysis and no extreme values were observed. The results of the study identified five moderate-level DIF items and one DDF item signaling an adverse effect on test fairness due to the existing biased items. Notably, these findings may have important implications for both language policymakers and test developers.
Towards a better understanding of hot-mixed mortars for the conservation of historic buildings: the role of water temperature and steam during lime slaking
Authors: Pesce Cecilia , Godina Martha C. , Henry Alison , Pesce Giovanni 
Published: June 2021

Abstract
According to various historic accounts and material evidence, the practice of producing lime mortars by mixing the quicklime with the sand (i.e. hot-mixing) before first slaking it with water was much more common in the past centuries than appreciated by most contemporary academics, conservation professionals and craftsmen. However, in the last 10 years, there has been resurgence in interest in hot-mixing. In such systems, the steam developed during the mixing is supposed to be crucial in determining the superior characteristics of the mortars, but in-depth investigations on the role of steam in hot-mixing are very few. This study reports the results of some experimental work investigating the effects of water temperature and steam used for lime slaking on the characteristics of lime and related mortars. In these tests, calcic quicklime was slaked in water at 20 and 75 °C, and with steam at 90 °C. Microstructure and mineralogical characteristics of the hydrates were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Mortars produced with these limes were tested for fresh (water retention and flowability) and hardened (compressive and flexural strength) properties. Carbonation was assessed using SEM, XRD and phenolphthalein tests. Results show that steam-slaked lime is characterised by portlandite crystals with smaller crystallite size and significantly different microstructure compared to that of water-slaked lime. Results also show that mortars made with steam-slaked lime have higher water retention and flowability than the mortars produced with water-slaked lime. Under conditions of comparatively low relative humidity (c 40–50%), carbonation is slower in the steam-slaked lime mortar due to the lower water content compared to water-slaked lime mortars. Overall, these results confirm anecdotal reports of better workability and water retention and suggest that this production technology, which is only rarely used nowadays, can produce mortars with improved characteristics, and provide a means by which to match the performance of some historic mortars, and create compatible materials for conservation and restoration work.
Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials
Authors: Silva Rebecca B. , Yap Christina , Carvajal Richard , Lee Shing M. 
Published: June 2021

PURPOSE Simulation studies have shown that novel designs such as the continual reassessment method and the Bayesian optimal interval (BOIN) design outperform the 3 + 3 design by recommending the maximum tolerated dose (MTD) more often, using less patients, and allotting more patients to the MTD. However, it is not clear whether these novel designs would have yielded different results in the context of real-world dose-finding trials. This is a commonly mentioned reason for the continuous use of 3 + 3 designs for oncology trials, with investigators considering simulation studies not sufficiently convincing to warrant the additional design complexity of novel designs. METHODS We randomly sampled 60 published dose-finding trials to obtain 22 that used the 3 + 3 design, identified an MTD, published toxicity data, and had more than two dose levels. We compared the published MTD with the estimated MTD using the continual reassessment method and BOIN using target toxicity rates of 25% and 30% and toxicity data from the trial. Moreover, we compared patient allocation and sample size assuming that these novel designs had been implemented. RESULTS Model-based designs chose dose levels higher than the published MTD in about 40% of the trials, with estimated and observed toxicity rates closer to the target toxicity rates of 25% and 30%. They also assigned less patients to suboptimal doses and permitted faster dose escalation. CONCLUSION This study using published dose-finding trials shows that novel designs would recommend different MTDs and confirms the advantages of these designs compared with the 3 + 3 design, which were demonstrated by simulation studies.
The Literary and Legendary Lives of the Onoe Bell
Authors: Fowler Sherry D. 
Published: June 2021

AbstractDuring the eighteenth and nineteenth centuries, a large eleventh-century bronze bell made in Korea became a grand attraction on the grounds of Onoe Shrine in Kakogawa, Japan. Although such bells are made of expensive material that require significant financial investment and technical skill, most are overlooked as common fixtures inside bell towers at Buddhist temples across Asia. Yet the bell at Onoe Shrine has a particularly complex and fascinating story to tell. Using object biography as an approach to study this unusual monument enables us to see how this bell became the popular subject of legends, travel-diary accounts, gazetteer entries, popular woodblock prints, and souvenirs made in a variety of materials. The bell's legendary life story accorded it the ability to solve human problems and use its voice to demand where it should be located, which fueled people's desire to see it with their own eyes and to make physical contact with it. This examination of the bell's intertwining life tales reveals how, after initially serving as a ritual object at a Korean Buddhist temple, it experienced dramatic transformations into a high-value export (or trafficked) commodity, Japanese poetic trope, shrine treasure, and tourist draw.
Doing the Reading: The Decline of Long Long-Form Reading in Higher Education
Authors: Baron Naomi S. , Mangen Anne 
Published: June 2021

Abstract
Long-form reading of literary and non-literary texts is historically an essential component of education. However, in many schooling contexts, the amount of long-form reading is diminishing. Are digital technologies augmenting this trend? And are these technologies affecting assignments and student reading patterns in other ways? This article begins by arguing for the relevance of long-form reading and then reviews prior research on how much assigned reading students in higher education report completing. With these findings as background, university faculty in the United States and Norway were surveyed to gauge contemporary reading assignments and student reading practices in humanities and social sciences disciplines, which traditionally are reading intensive. Several of the questions focused on the potential impact of technology on reading assignments, including their length and complexity. This exploratory research suggests that digital technologies are contributing to reduced long-form reading in higher education.
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7
Authors: Blasius T. Lynne , Yue Yang , Prasad RaghuRam , Liu Xinglei , Gennerich Arne , Verhey Kristen J. 
Published: June 2021

ABSTRACT
The kinesin-4 member KIF7 plays critical roles in Hedgehog signaling in vertebrate cells. KIF7 is an atypical kinesin as it binds to microtubules but is immotile. We demonstrate that, like conventional kinesins, KIF7 is regulated by auto-inhibition, as the full-length protein is inactive for microtubule binding in cells. We identify a segment, the inhibitory coiled coil (inhCC), that is required for auto-inhibition of KIF7, whereas the adjacent regulatory coiled coil (rCC) that contributes to auto-inhibition of the motile kinesin-4s KIF21A and KIF21B is not sufficient for KIF7 auto-inhibition. Disease-associated mutations in the inhCC relieve auto-inhibition and result in strong microtubule binding. Surprisingly, uninhibited KIF7 proteins did not bind preferentially to or track the plus ends of growing microtubules in cells, as suggested by previous in vitro work, but rather bound along cytosolic and axonemal microtubules. Localization to the tip of the primary cilium also required the inhCC, and could be increased by disease-associated mutations regardless of the auto-inhibition state of the protein. These findings suggest that loss of KIF7 auto-inhibition and/or altered cilium tip localization can contribute to the pathogenesis of human disease.
Case Report: Spontaneous simultaneous coronary and carotid dissection in a young cannabis user
Authors: Ibn Hadj Amor Hassen , Touil Imen , Boukriba Seif , Bouchnak Skander , Kraiem Salma , Rouabhia Ramzi 
Published: June 2021

Due to legalization of its consumption in some countries and its medical use as well as low toxic potential, cannabis remains the most widely used drug around the world and the rate of usage is only increasing. Nevertheless, there are several case reports of vascular complications following cannabis use even in young people without cardiovascular risk factors. We report the case of a cannabis smoker presenting to the emergency room for an ischemic stroke associated with an acute coronary syndrome related to a spontaneous simultaneous double dissection of the carotid artery and the left anterior descending artery, with a favourable outcome under medical treatment. This case shows the seriousness of complications due to the cannabis consumption, hence the need to limit or even prohibit its consumption.
Using Social Network Activity Data to Identify and Target Job Seekers
Authors: Ebbes Peter , Netzer Oded 
Published: June 2021

An important challenge for many firms is to identify the life transitions of its customers, such as job searching, expecting a child, or purchasing a home. Inferring such transitions, which are generally unobserved to the firm, can offer the firms opportunities to be more relevant to their customers. In this paper, we demonstrate how a social network platform can leverage its longitudinal user data to identify which of its users are likely to be job seekers. Identifying job seekers is at the heart of the business model of professional social network platforms. Our proposed approach builds on the hidden Markov model (HMM) framework to recover the latent state of job search from noisy signals obtained from social network activity data. Specifically, we use the latent states of the HMM to fuse cross-sectional survey responses to a job-seeking status question with longitudinal user activity data, resulting in a partially HMM. Thus, in some time periods, and for some users, we observe a direct measure of the true job-seeking status. We demonstrate that the proposed model can predict not only which users are likely to be job seeking at any point in time but also what activities on the platform are associated with job search and how long the users have been job seeking. Furthermore, we find that targeting job seekers based on our proposed approach can lead to a 29% increase in profits of a targeting campaign relative to the approach that was used by the social network platform.This paper was accepted by Juanjuan Zhang, marketing.
Compassionate and respectful care among outpatient clients at public health facilities in Northwest Ethiopia: A mixed-methods study
Authors: Abate Manaye , Debie Ayal , Tsehay Chalie Tadie , Amare Tsegaw 
Published: June 2021

Introduction
Compassionate and respectful care is a pillar for improving health-seeking behaviour. It has given much attention globally, following the concerns that healthcare often falls significantly; however, less research emphasis was paid in the last decade. Therefore, this study aims to assess compassionate and respectful care and associated factors among outpatient clients at public health facilities in Northwest Ethiopia, 2020.

Methods
A facility-based quantitative cross-sectional study supplemented with the qualitative findings was conducted from 30 February to 30 March 2020. A semi-structured interviewer-administered questionnaire was used to collect the quantitative data among 593 participants. Systematic and purposive sampling techniques were used to select the quantitative and qualitative participants, respectively. A semi-structured interview guide was also employed for the qualitative data collection. Epi-Data version 4.6 and SPSS version 25 were used for data entry and analysis, respectively. The bi-variable and multivariable logistic regression model was fitted to identify the factors associated with each outcome variable (compassionate and respectful care separately). Adjusted odds ratio (AOR) with 95% confidence interval (CI) and p-value less than 0.05 were used to declare the strength and factors statistically associated with the outcome variables.

Results
Overall, 72.8% and 82.6% of the respondents experienced compassionate and respectful care, respectively. Patients attending primary or above education (AOR: 0.35; 95% CI: 0.21–0.59), attending at the hospital (AOR: 0.59; 95% CI: 0.39–0.88), new clients (AOR: 0.33; 95% CI: 0.16–0.70) and service users who had three or more visits (AOR: 0.34; 95% CI: 0.17–0.71) were negatively associated with compassionate care. On the other hand, female patients (AOR = 0.53; 95% CI: 0.32–0.87), aged over 36 years (AOR = 0.43; 95% CI: 0.20–0.90), primary or above school attended clients (AOR = 0.18; 95% CI: 0.09–0.36), waiting two or more hours (AOR = 0.28; 95% CI: 0.13–0.62), and use public or private transport access (AOR: 0.49; 95% CI: 0.29–0.83) were negatively associated with a respectful care.

Conclusion
Compassionate and respectful care provided to the outpatient clients in public health facilities of northwest Ethiopia was high. However, our result suggests that immediate actions are necessary to address respectful and compassionate care at hospitals, and hospital management should adopt mitigation measures. Consideration should be given to foster patient-centric services and educate the health care workers about compassionate and respectful care.
The p16/ki-67 assay is a safe, effective and rapid approach to triage women with mild cervical lesions
Authors: Magkana Maria , Mentzelopoulou Panagiota , Magkana Ekaterini , Pampanos Andreas , Daskalakis Georgios , Domali Ekaterini , Rodolakis Alexandros , Pappa Kalliopi 
Published: June 2021

Objective
The aim of this study was to evaluate the diagnostic accuracy and efficiency of p16/ki-67 dual stain in the identification of CIN2+ lesions, in Greek women with ASCUS or LSIL cytology.

Methods
A total of 200 women, 20 to 60 years old, were enrolled in the study. All samples were cytologically evaluated and performed for p16/ki-67 and high-risk HPV (HR-HPV) test. All patients were referred to colposcopy for biopsy and histological evaluation. Three cervical cancer (CC) screening strategies were designed and the total direct medical costs of the procedures during our clinical trial were evaluated, from a healthcare perspective.

Results
HPV 16 as expected was the most common HR-HPV type followed by HPV 31 and HPV 51. The risk for CIN2+ was significantly higher in HPV 16/18 positive cases. p16/ki-67 demonstrated a high sensitivity for CIN2+ identification in both ASCUS and LSIL groups (90.4% and 95%, respectively). HR-HPV test with sensitivity 52.3% and 65.5%, as well as colposcopy with sensitivity 14.3% and 36% respectively in ASCUS and LSIL group, showed inferior results compared to p16/ki-67. The specificity of p16/ki-67 for ASCUS and LSIL was 97.2% and 95.2% respectively, inferior only to colposcopy: 100% and 100%, lacking however statistical significance. HR-HPV test instead, presented the lowest specificity: 76.4% and 71.4% respectively in comparison to the other two methods. From a healthcare perspective, the costs and benefits of the tests implementation for the annual screening and triaging, in three CC screening strategies, were also calculated and discussed.

Conclusions
The results of the study indicate that p16/ki-67 is a safe and rapid assay that could be used to detect CIN2+ among women with mild cervical lesions, presenting both high sensitivity and specificity and could minimize the psychological and economic burden of HPV screening.
COVID-19 vaccine prioritization of incarcerated people relative to other vulnerable groups: An analysis of state plans
Authors: Strodel Rachel , Dayton Lauren , Garrison-Desany Henri M. , Eber Gabriel , Beyrer Chris , Arscott Joyell , Rubenstein Leonard , Sufrin Carolyn 
Published: June 2021

Background
Carceral facilities are epicenters of the COVID-19 pandemic, placing incarcerated people at an elevated risk of COVID-19 infection. Due to the initial limited availability of COVID-19 vaccines in the United States, all states have developed allocation plans that outline a phased distribution. This study uses document analysis to compare the relative prioritization of incarcerated people, correctional staff, and other groups at increased risk of COVID-19 infection and morbidity.

Methods and findings
We conducted a document analysis of the vaccine dissemination plans of all 50 US states and the District of Columbia using a triple-coding method. Documents included state COVID-19 vaccination plans and supplemental materials on vaccine prioritization from state health department websites as of December 31, 2020. We found that 22% of states prioritized incarcerated people in Phase 1, 29% of states in Phase 2, and 2% in Phase 3, while 47% of states did not explicitly specify in which phase people who are incarcerated will be eligible for vaccination. Incarcerated people were consistently not prioritized in Phase 1, while other vulnerable groups who shared similar environmental risk received this early prioritization. States’ plans prioritized in Phase 1: prison and jail workers (49%), law enforcement (63%), seniors (65+ years, 59%), and long-term care facility residents (100%).

Conclusions
This study demonstrates that states’ COVID-19 vaccine allocation plans do not prioritize incarcerated people and provide little to no guidance on vaccination protocols if they fall under other high-risk categories that receive earlier priority. Deprioritizing incarcerated people for vaccination misses a crucial opportunity for COVID-19 mitigation. It also raises ethical and equity concerns. As states move forward with their vaccine distribution, further work must be done to prioritize ethical allocation and distribution of COVID-19 vaccines to incarcerated people.
A case of septic shock which postmortem pathological autopsy revealed bacterial myocardial abscess
Authors: Tamai Tsunenori 
Published: June 2021

Background and purpose: The myocardial abscess is a scarce condition, but it is significant due to its high mortality. We aimed to seek insight into myocardial abscess by presenting a case report.
Methods: A 73 years old male was emergently transferred to our hospital with disorientation and hypotension. He had a past medical history of diabetes mellitus, hypertension, myocardial infarction, atrial fibrillation, and calculous cholecystitis. He had complained of lumbago since 1 week before arrival at our hospital. We diagnosed him with septic shock due to pyogenic spondylitis and psoas abscess by the laboratory and imaging findings. We could not find abnormality in his cardiac status of echocardiography. Despite the treatment, his condition worsened rapidly, and he died after 24 hours of arrival. We performed a postmortem pathological autopsy, which revealed the condition of myocardial abscesses. We examined medical literature about a myocardial abscess.
Results: According to a previous treatise, pyogenic spondylitis was reported as a causative disease of the myocardial abscess to the same extent as infective endocarditis. Bacterial myocarditis may lead to decreased cardiac function and arrhythmias. Our case did not show cardiac asynergy, decreased cardiac function, and sudden fatal arrhythmias during the course. We thought that the myocardial abscess was due to a hematogenous metastasis from the pyogenic spondylitis. And we thought the direct cause of death was septic shock, not the myocardial abscess.
Conclusions: We experienced a fatal septic shock case that revealed myocardial abscess by the postmortem pathological autopsy. It is possible that we cannot notice the existence of myocardial abscess without a pathological autopsy.
Initial boundary value problems for the three-dimensional compressible elastic Navier-Stokes-Poisson equations
Authors: Wang Yong , Wu Wenpei 
Published: June 2021

Abstract
We study the initial-boundary value problems of the three-dimensional compressible elastic Navier-Stokes-Poisson equations under the Dirichlet or Neumann boundary condition for the electrostatic potential. The unique global solution near a constant equilibrium state in H
2 space is obtained. Moreover, we prove that the solution decays to the equilibrium state at an exponential rate as time tends to infinity. This is the first result for the three-dimensional elastic Navier-Stokes-Poisson equations under various boundary conditions for the electrostatic potential.
Evolution of university internationalisation strategies and language policies: challenges and opportunities for language centres
Authors: Critchley Mark , Wyburd Jocelyn 
Published: June 2021

Abstract
In this paper, we explore how language centres can and need to seize the initiative in matters of internationalisation, language policy and supporting a multilingual and multicultural institutional environment. We identify and explore a number of challenges and opportunities, using the situation in the United Kingdom as our example, demonstrating how language centres can evidence their existing contribution to a wider interpretation of internationalisation than is often found within university international strategies. In that context, we explore the skillset of the ‘global graduate’ to which language centres can contribute extensively. We demonstrate how language centres can contribute to the achievement of research excellence in an international higher education environment and the dimensions of institutional language policies within the context of a global university. Finally, we share the AULC manifesto for the role of language centres within global universities and propose that CercleS might elaborate a similar manifesto to raise the profile of language centres at the heart of higher education internationalisation.