bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pituitary society expert Delphi consensus: operative workflow in endoscopic transsphenoidal pituitary adenoma resection
Authors: Marcus Hani J. , Khan Danyal Z. , Borg Anouk , Buchfelder Michael , Cetas Justin S. , Collins Justin W. , Dorward Neil L. , Fleseriu Maria , Gurnell Mark , Javadpour Mohsen , Jones Pamela S. , Koh Chan Hee , Layard Horsfall Hugo , Mamelak Adam N. , Mortini Pietro , Muirhead William , Oyesiku Nelson M. , Schwartz Theodore H. , Sinha Saurabh , Stoyanov Danail , Syro Luis V. , Tsermoulas Georgios , Williams Adam , Winder Mark J. , Zada Gabriel , Laws Edward R. 
Published: July 2021

Abstract
Purpose
Surgical workflow analysis seeks to systematically break down operations into hierarchal components. It facilitates education, training, and understanding of surgical variations. There are known educational demands and variations in surgical practice in endoscopic transsphenoidal approaches to pituitary adenomas. Through an iterative consensus process, we generated a surgical workflow reflective of contemporary surgical practice.

Methods
A mixed-methods consensus process composed of a literature review and iterative Delphi surveys was carried out within the Pituitary Society. Each round of the survey was repeated until data saturation and > 90% consensus was reached.

Results
There was a 100% response rate and no attrition across both Delphi rounds. Eighteen international expert panel members participated. An extensive workflow of 4 phases (nasal, sphenoid, sellar and closure) and 40 steps, with associated technical errors and adverse events, were agreed upon by 100% of panel members across rounds. Both core and case-specific or surgeon-specific variations in operative steps were captured.

Conclusions
Through an international expert panel consensus, a workflow for the performance of endoscopic transsphenoidal pituitary adenoma resection has been generated. This workflow captures a wide range of contemporary operative practice. The agreed “core” steps will serve as a foundation for education, training, assessment and technological development (e.g. models and simulators). The “optional” steps highlight areas of heterogeneity of practice that will benefit from further research (e.g. methods of skull base repair). Further adjustments could be made to increase applicability around the world.
The Ethics of Automated Vehicles: Why Self-driving Cars Should not Swerve in Dilemma Cases
Authors: Lawlor Rob 
Published: July 2021

AbstractIn this paper, I will argue that automated vehicles should not swerve to avoid a person or vehicle in its path, unless they can do so without imposing risks onto others. I will argue that this is the conclusion that we should reach even if we start by assuming that we should divert the trolley in the standard trolley case (in which the trolley will hit and kill five people on the track, unless it is diverted onto a different track, where it will hit and kill just one person). In defence of this claim, I appeal to the distribution of moral and legal responsibilities, highlighting the importance of safe spaces, and arguing in favour of constraints on what can be done to minimise casualties. My arguments draw on the methodology associated with the trolley problem. As such, this paper also defends this methodology, highlighting a number of ways in which authors misunderstand and misrepresent the trolley problem. For example, the ‘trolley problem’ is not the ‘name given by philosophers to classic examples of unavoidable crash scenarios, historically involving runaway trolleys’, as Millar suggests, and trolley cases should not be compared with ‘model building in the (social) sciences’, as Gogoll and Müller suggest. Trolley cases have more in common with lab experiments than model building, and the problem referred to in the trolley problem is not the problem of deciding what to do in any one case. Rather, it refers to the problem of explaining what appear to be conflicting intuitions when we consider two cases together. The problem, for example, could be: how do we justify the claim that automated vehicles should not swerve even if we accept the claim that we should divert the trolley in an apparently similar trolley case?
Small firms and the COVID-19 insolvency gap
Authors: Dörr Julian Oliver , Licht Georg , Murmann Simona 
Published: July 2021

AbstractCOVID-19 placed a special role on fiscal policy in rescuing companies short of liquidity from insolvency. In the first months of the crisis, SMEs as the backbone of Germany’s economy benefited from large and mainly indiscriminate aid measures. Avoiding business failures in a whatever-it-takes fashion contrasts, however, with the cleansing mechanism of economic crises: a mechanism which forces unviable firms out of the market, thereby reallocating resources efficiently. By focusing on firms’ pre-crisis financial standing, we estimate the extent to which the policy response induced an insolvency gap and analyze whether the gap is characterized by firms which were already struggling before the pandemic. With the policy measures being focused on smaller firms, we also examine whether this insolvency gap differs with respect to firm size. Our results show that the COVID-19 policy response in Germany has triggered a backlog of insolvencies that is particularly pronounced among financially weak, small firms, having potential long-term implications on entrepreneurship and economic recovery.Plain English Summary This study analyzes the extent to which the strong policy support to companies in the early phase of the COVID-19 crisis has prevented a large wave of corporate insolvencies. Using data of about 1.5 million German companies, it is shown that it was mainly smaller firms that experienced strong financial distress and would have gone bankrupt without policy assistance. In times of crises, insolvencies usually allow for a reallocation of employees and capital to more efficient firms. However, the analysis reveals that this ‘cleansing effect’ is hampered in the current crisis as the largely indiscriminate granting of liquidity subsidies and the temporary suspension of the duty to file for insolvency have caused an insolvency gap that is driven by firms which were already in a weak financial position before the crisis. Overall, the insolvency gap is estimated to affect around 25,000 companies, a substantial number compared to the around 16,300 actual insolvencies in 2020. In the ongoing crisis, policy makers should prefer instruments favoring entrepreneurs who respond innovatively to the pandemic instead of prolonging the survival of near-insolvent firms.
Solidarity of the shaken: from the experience (Erlebnis) to history
Authors: Belejkaničová Michaela 
Published: July 2021

AbstractIn his Heretical Essays, Jan Patočka introduces the concept of the solidarity of the shaken. He argues that it emerges in the conditions of political violence—the frontline experience (Fronterlebnis). Moreover, Patočka brings into discussion the puzzling concepts of day, night, metanoia and sacrifice, which only further problematise the idea. Researching how other thinkers have examined the phenomenon of the frontline experience, it becomes obvious that Patočka did not invent the obscure vocabulary ex nihilo. Concepts such as frontline experience, sacrifice and the metaphors of the day and night were commonly used by thinkers in the inter-war and post-war eras in their examination of community (Gemeinschaft). This study aims to reconstruct the idea of the solidarity of the shaken as contextualized within a broader scholarly debate on the concept of community (Gemeinschaft). Through the critical dialogue between Patočka’s works and the works of Ernst Jünger and Pierre Teilhard de Chardin, this study will portray how Patočka, in his discourse on the frontline experience, follows the usual pattern of overcoming one’s individuality, transcending and opening up to the constitution of solidarity. This paper will argue that Patočka defined the solidarity of the shaken in an attempt to revive the positive aspects of a community and break with the regressive (if not sinister) uses to which it was put in the twentieth century.
Models, structures, and the explanatory role of mathematics in empirical science
Authors: Leng Mary 
Published: July 2021

AbstractAre there genuine mathematical explanations of physical phenomena, and if so, how can mathematical theories, which are typically thought to concern abstract mathematical objects, explain contingent empirical matters? The answer, I argue, is in seeing an important range of mathematical explanations asstructural explanations, where structural explanations explain a phenomenon by showing it to have been an inevitable consequence of the structural features instantiated in the physical system under consideration. Such explanations are best cast as deductive arguments which, by virtue of their form, establish that,giventhe mathematical structure instantiated in the physical system under consideration, the explanandumhadto occur. Against the claims of platonists such as Alan Baker and Mark Colyvan, I argue that formulating mathematical explanations as structural explanations in this way shows that we can accept that mathematics can play an indispensable explanatory role in empirical science without committing to the existence of any abstract mathematical objects.
Removing politics from innovations that improve food security
Authors: Smyth Stuart J. , McHughen Alan , Entine Jon , Kershen Drew , Ramage Carl , Parrott Wayne 
Published: July 2021

AbstractGenetically modified (GM) organisms and crops have been a feature of food production for over 30 years. Despite extensive science-based risk assessment, the public and many politicians remain concerned with the genetic manipulation of crops, particularly food crops. Many governments have addressed public concern through biosafety legislation and regulatory frameworks that identify and regulate risks to ensure human health and environmental safety. These domestic regulatory frameworks align to international scientific risk assessment methodologies on a case-by-case basis. Regulatory agencies in 70 countries around the world have conducted in excess of 4400 risk assessments, all reaching the same conclusion: GM crops and foods that have been assessed provide no greater risk to human health or the environment than non-GM crops and foods. Yet, while the science regarding the safety of GM crops and food appears conclusive and societal benefits have been globally demonstrated, the use of innovative products have only contributed minimal improvements to global food security. Regrettably, politically-motivated regulatory barriers are currently being implemented with the next genomic innovation, genome editing, the implications of which are also discussed in this article. A decade of reduced global food insecurity was witnessed from 2005 to 2015, but regrettably, the figure has subsequently risen. Why is this the case? Reasons have been attributed to climate variability, biotic and abiotic stresses, lack of access to innovative technologies and political interference in decision making processes. This commentary highlights how political interference in the regulatory approval process of GM crops is adversely affecting the adoption of innovative, yield enhancing crop varieties, thereby limiting food security opportunities in food insecure economies.
Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection
Authors: Porcaro Antonio Benito , Cerrato Clara , Tafuri Alessandro , Bianchi Alberto , Gallina Sebastian , Orlando Rossella , Amigoni Nelia , Rizzetto Riccardo , Gozzo Alessandra , Migliorini Filippo , Zecchini Antoniolli Stefano , Monaco Carmelo , Brunelli Matteo , Cerruto Maria Angela , Antonelli Alessandro 
Published: July 2021

Abstract
Objective
To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND).

Materials and methods
Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present (N = 0) or with one (N = 1) or more than one metastatic node (N > 1). The risk of multiple pelvic lymph node metastasis (N > 1, mPLNM) was assessed by comparing it to the other two groups (N > 1 vs. N = 0 and N > 1 vs. N = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT > 1) and tumor grade group greater than two (ISUP > 2).

Results
Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N = 1 and 31 (5%) with N > 1. On multivariate analysis, ET was inversely associated with the risk of N > 1 when compared to both N = 0 (odds ratio, OR 0.997; CI 0.994–1; p = 0.027) as well as with N = 1 cases (OR 0.994; 95% CI 0.989–1.000; p = 0.015).

Conclusions
In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.
Sedimentology and sediment geochemistry of the pelagic Paryab section (Zagros Mountains, Iran): implications for sea level fluctuations and paleoenvironments in the late Paleocene to middle Eocene
Authors: Azami Seyed Hamidreza , Wagreich Michael , Mehrizi Maryam Mortazavi , Gharaie Mohamad Hosein Mahmudy , Gier Susanne , Leckie R. Mark 
Published: July 2021

AbstractSedimentological and geochemical records are presented for an upper Paleocene to middle Eocene deep-water pelagic succession of the Pabdeh Formation in the Paryab section, Zagros Mountains, NW, Iran. In this study, grain-size statistical parameters, cumulative curves, and bivariate analysis on twenty-five sediment samples were used to decipher depositional processes and paleoenvironments. XRD analysis of the fine-grained silt to clay sediments indicates that quartz, calcite, ankerite/dolomite, and clay minerals such as illite, chlorite, and kaolinite constitute the main minerals within these sediments. Elemental and isotopic chemostratigraphies are used to infer depositional conditions and sea level trends through time. TOC-CaCO3 trends of the samples are used to interpret the type of deposition and sediment accumulation rates, rhythmic bedding, and identification of regressional and transgressional phases. In the studied section, the manganese contents exhibit a declining trend along the lowstand systems tract that terminates in a sea level lowstand and the subsequent start of a transgressive trend. Some geochemical parameters such as Mn values and δ13C contents of sediments along a sequence can be used as potential sea level proxies that are tested in this study. The Paleocene-Eocene Thermal Maximum (PETM) interval of the Pabdeh Formation coincides with increasing Mn contents and Mn/Al ratios. Ti/Al and Si/Al ratios show contrasting trends to Mn values and Mn/Al ratios. Generally, elemental and isotopic results of the Pabdeh Formation confirm the presence of a long-term three-stage sea level cycle in the studied interval that is related to the PETM event. Based on elemental analyses such as Co, Mo, Ni, V, and Cr contents, the Pabdeh Formation sediments were deposited in suboxic to slightly anoxic conditions.
Trait profile of maize varieties preferred by farmers and value chain actors in northern Ghana
Authors: Adu Gloria Boakyewaa , Badu-Apraku Baffour , Akromah Richard , Amegbor Isaac Kodzo , Adogoba Desmond Sunday , Haruna Alidu , Manigben Kulai Amadu , Aboyadana Paulina Abanpoka , Wiredu Alexander Nimo 
Published: July 2021

AbstractPlant breeders’ knowledge of precise traits preferred by variety users would accelerate varietal turnover and widen adoption of newly developed maize varieties in Ghana. The objective of this research was to provide empirical evidence of trait preferences of farmers and other actors in the maize value chain in northern Ghana, based on which research strategies for maize improvement could be formulated. Participatory rural appraisal was conducted in 2016 to determine key traits preferred by maize value chain actors across the three regions in northern Ghana. A total of 279 maize value chain actors were interviewed. Different scoring and ranking techniques were used to assess the maize traits preferred by the different actors. Participatory variety selection trials were also conducted in the Tolon, West Gonja, Binduri, and Sissala East districts in northern Ghana from 2014 to 2016. The mother-baby trial approach was used to evaluate eight hybrids with 3000 farmers. Data on yield and agronomic performance of the hybrids and farmer’s selection criteria were collected. Data analyses were performed using GenStat Edition 16 and SPSS Edition 20 statistical packages. The participatory rural appraisal method identified farmers, input dealers, traders, and processors as the primary maize value chain actors in the study areas. Trait preferences of the different actors overlapped and revolved around grain quality including nutritional value, and stress tolerance and grain yield. Results of the participatory variety selection study revealed that across districts, farmers preferred high-yielding varieties with multiple cobs per plant, white grain endosperm color, and bigger and fully filled cobs. For the first time, our holistic assessment of the trait preferences of key actors of the maize value chain in northern Ghana revealed a comprehensive list of traits, which could be used by breeders to develop varieties that may be preferred by all value chain actors in northern Ghana.
Equal Protection by Race with Stop and Frisk: a Risk-Adjusted Disparity (RAD) Index for Balanced Policing
Authors: Sherman Lawrence W. , Kumar Sumit 
Published: July 2021

Abstract
Research Question
Can racial equity in crime and policing be measured with the use of a Risk-Adjusted Disparity (RAD) Index of the degree to which policing across racial categories is “balanced” in its ratios of preventive police actions per 100 serious crimes committed against members of each racial category?

Data
Office of National Statistics (ONS) reports on crime and policing in England and Wales, and Dorset Police data on violent crime victimization and stop-search by race of suspect across the 452 Lower-Layer Super-Output Levels in Dorset.

Methods
We conceptualize the problem of equal protection under law as fundamentally protecting the lives and liberties of each citizen from criminal harms, as well as from disproportionately intrusive policing. We combine these dimensions into a single metric that defines proportionality of policing in relation to risk of violent crime victimization, such that whatever intrusion on liberty is applied for the aim of protection can be equalized across racial groups.

Findings
The use of a Risk-Adjusted Disparity (RAD) Index to measure reliably the equality of police intrusions across racial groups based on victimization rates can be illustrated by adjusting for homicide. In the past decade, the population-based disparity rate shows that Blacks are stopped by police nine times more often than whites. When that rate is adjusted for the differential risk of homicide in the two groups, the disparity estimate drops from 800% to 58%. Other changes of major magnitude result from using the RAD Index.

Conclusions
We conclude that an index of proactive policing using victimizations by race is more likely to lead to equal protection of law than a residential population-based metric of proactive police actions, as is commonly used in official reporting. A victim-based, Risk-Adjusted (RAD) Index for measuring racial disparity might focus police efforts on the 5% of local areas where serious violence is concentrated, and deflect stops away from the vast majority of areas that have little serious crime.
Parametric oscillation and amplification with gate controlled capacitor-within-capacitor
Authors: Grebel H. 
Published: July 2021

AbstractParametric oscillators and parametric amplifiers are known for their ‘quiet’ operation and find new applications in quantum circuitry. A Capacitor-within-Capacitor (CWC) is a nested electronic element that has two components: the cell (e.g., the outer capacitor) and the gate (e.g., the inner capacitor). Here we provide analysis and experiments on diode-interfaced, CWC that exhibit parametric oscillations and parametric amplifications. By replacing the diode with a doped nano-graphene junction, we demonstrated a new structure whose doping may be electronically and chemically controlled. Advantages of these elements are in their simplicity, large relative capacitance change (of the order of 50%), separation of pump and signal channels and possibility for large integration.
Comparison between SARIMA and Holt–Winters models for forecasting monthly streamflow in the western region of Cuba
Authors: Alonso Brito Gustavo Reinel , Rivero Villaverde Anaily , Lau Quan Andrés , Ruíz Pérez María Elena 
Published: July 2021

Abstract
The present study aims to compare SARIMA and Holt–Winters model forecasts of mean monthly flow at the V Aniversario basin, western Cuba. Model selection and model assessment are carried out with a rolling cross-validation scheme using mean monthly flow observations from the period 1971–1990. Model performance is analyzed in one- and two-year forecast lead times, and comparisons are made based on mean squared error, root mean squared error, mean absolute error and the Nash–Sutcliffe efficiency; all these statistics are computed from observed and simulated time series at the outlet of the basin. The major findings show that Holt–Winters models had better performance in reproducing the mean series seasonality when the training observations were insufficient, while for longer training subsets, both models were equally competitive in forecasting one year ahead. SARIMA models were found to be more reliable for longer lead-time forecasts, and their limitations after being trained on short observation periods are due to overfitting problems.

Article Highlights

Comparison based on rolling cross-validation revealed the models forecasts sensibility to available observations amount.

HW and SARIMA models perform better when limited observations or long-view forecasting, respectively, otherwise they do similar.

HW models were superior modeling less variable monthly flows while SARIMA models better forecast the highly variable periods.