bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of dynamic behaviour of porous media including micro-cracks by ordinary state-based peridynamics
Authors: Ozdemir M. , Oterkus S. , Oterkus E. , Amin I. , Nguyen C. T. , Tanaka S. , El-Aassar A. , Shawky H. 
Published: September 2021

AbstractReliable evaluation of mechanical response in a porous solid might be challenging without any simplified assumptions. Peridynamics (PD) perform very well on a medium including pores owing to its definition, which is valid for entire domain regardless of any existed discontinuities. Accordingly, porosity is defined by randomly removing the PD interactions between the material points. As wave propagation in a solid body can be regarded as an indication of the material properties, wave propagation in porous media under an impact loading is studied first and average wave speeds are compared with the available reference results. A good agreement between the present and the reference results is achieved. Then, micro-cracks are introduced into porous media to investigate their influence on the elastic wave propagation. The micro-cracks are considered in both random and regular patterns by varying the number of cracks and their orientation. As the porosity ratio increases, it is observed that wave propagation speed drops considerably as expected. As for the cases with micro-cracks, the average wave speeds are not influenced significantly in random micro-crack configurations, while regular micro-cracks play a noticeable role in absorbing wave propagation depending on their orientation as well as the number of crack arrays in y-direction.
Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report
Authors: Davies Cathy , Appiah-Kusi Elizabeth , Wilson Robin , Blest-Hopley Grace , Bossong Matthijs G. , Valmaggia Lucia , Brammer Michael , Perez Jesus , Allen Paul , Murray Robin M. , McGuire Philip , Bhattacharyya Sagnik 
Published: September 2021

AbstractEvidence suggests that people at Clinical High Risk for Psychosis (CHR) have a blunted cortisol response to stress and altered mediotemporal activation during fear processing, which may be neuroendocrine–neuronal signatures of maladaptive threat responses. However, whether these facets are associated with each other and how this relationship is affected by cannabidiol treatment is unknown. We examined the relationship between cortisol response to social stress and mediotemporal function during fear processing in healthy people and in CHR patients. In exploratory analyses, we investigated whether treatment with cannabidiol in CHR individuals could normalise any putative alterations in cortisol-mediotemporal coupling. 33 CHR patients were randomised to 600 mg cannabidiol or placebo treatment. Healthy controls (n = 19) did not receive any drug. Mediotemporal function was assessed using a fearful face-processing functional magnetic resonance imaging paradigm. Serum cortisol and anxiety were measured immediately following the Trier Social Stress Test. The relationship between cortisol and mediotemporal blood-oxygen-level-dependent haemodynamic response was investigated using linear regression. In healthy controls, there was a significant negative relationship between cortisol and parahippocampal activation (p = 0.023), such that the higher the cortisol levels induced by social stress, the lower the parahippocampal activation (greater deactivation) during fear processing. This relationship differed significantly between the control and placebo groups (p = 0.033), but not between the placebo and cannabidiol groups (p = 0.67). Our preliminary findings suggest that the parahippocampal response to fear processing may be associated with the neuroendocrine (cortisol) response to experimentally induced social stress, and that this relationship may be altered in patients at clinical high risk for psychosis.
Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration
Authors: Cozzi Mariano , Monteduro Davide , Parrulli Salvatore , Ristoldo Federica , Corvi Federico , Zicarelli Federico , Staurenghi Giovanni , Invernizzi Alessandro 
Published: September 2021

Abstract
Purpose
The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (nAMD).

Methods
In this retrospective, observational case series study, patients diagnosed with nAMD and prechoroidal cleft associated with other activity signs of the macular neovascularization (MNV) were included. Structural optical coherence tomography (OCT) scans were evaluated to obtain anatomical measurements of prechoroidal cleft and PED at three different visits (T0, inactive MNV; T1, active MNV; T2, treated inactive MNV). The variations in size of the cleft and the PED were correlated with nAMD activity.

Results
Twenty-nine eyes from 27 patients were included. The subfoveal measurements showed a significant increase of prechoroidal cleft height and width from T0 to T1 (P < 0.05) and a subsequent decrease of the cleft height after treatment with anti-VEGF agents (P = 0.004). A similar significant trend was observed for the greatest prechoroidal cleft height and width, obtained assessing the whole OCT raster. In the multivariate analysis, the cleft height was significantly affected by both time (P = 0.001) and PED height (P < 0.0001). By contrast, the effect of fibrovascular tissue size within the PED was not significant. Visual acuity did not correlate with prechoroidal cleft size.

Conclusion
Prechoroidal cleft increased in association with MNV reactivation and decreased after treatment. Our results suggest that prechoroidal cleft could represent an accumulation of fluid actively exudating from the MNV and should be considered a sign of nAMD activity.
Long-term experience with a collagen-elastin scaffold in combination with split-thickness skin grafts for the treatment of full-thickness soft tissue defects: improvements in outcome—a retrospective cohort study and case report
Authors: Lempert Maximilian , Halvachizadeh Sascha , Salfelder Clara Charlotte , Neuhaus Valentin , Pape Hans-Christoph , Jukema Gerrolt Nico 
Published: September 2021

AbstractPurposeThe management of severe soft tissue injuries to the extremities with full-thickness wounds poses a challenge to the patient and surgeon. Dermal substitutes are used increasingly in these defects. The aim of this study was to investigate the impact of the type of injury on the success rate of Matriderm® (MD)-augmented split-thickness skin grafting, as well as the role of negative pressure wound therapy (NPWT) in preconditioning of the wounds, with a special focus on the reduction of the bioburden.MethodsIn this study, 45 wounds (44 affecting lower extremities (97.7%)), resulting from different types of injuries: soft tissue (ST), soft tissue complications from closed fracture (F), and open fracture (OF) in 43 patients (age 55.0 ± 18.2 years, 46.7% female), were treated with the simultaneous application of MD and split-thickness skin grafting. The study was designed as a retrospective cohort study from March 2013 to March 2020. Patients were stratified into three groups: ST, F, and OF. Outcome variables were defined as the recurrence of treated wound defects, which required revision surgery, and the reduction of bioburden in terms of reduction of number of different bacterial strains. For statistical analysis, Student’s t-test, analysis of variance (ANOVA), Mann–Whitney U test, and Pearson’s chi-squared test were used.ResultsThere was no significant difference in the rate of recurrence in the different groups (F: 0%; OF: 11.1%; ST: 9.5%). The duration of VAC therapy significantly differed between the groups (F: 10.8 days; OF: 22.7 days; ST: 12.6 days (p < 0.05)). A clinically significant reduction of bioburden was achieved with NPWT (bacterial shift (mean (SD), F: − 2.25 (1.89); OF: − 1.9 (1.37); ST: − 2.6 (2.2)).ConclusionMD-augmented split-thickness skin grafting is an appropriate treatment option for full-thickness wounds with take rates of about 90%. The complexity of an injury significantly impacts the duration of the soft tissue treatment but does not have an influence on the take rate. NPWT leads to a relevant reduction of bioburden and is therefore an important part in the preconditioning of full-thickness wounds.
Purely ropivacaine-based TEA vs single TAP block in pain management after elective laparoscopic colon surgery within an upgraded institutional ERAS program
Authors: Bumblyte Vilma , Rasilainen Suvi K. , Ehrlich Anu , Scheinin Tom , Kontinen Vesa K. , Sevon Aino , Vääräniemi Heikki , Schramko Alexey A. 
Published: September 2021

Abstract
Background
The aim of this study was to compare thoracic epidural analgesia (TEA) with transversus abdominis plane (TAP) block in post-operative pain management after laparoscopic colon surgery.

Methods
One hundred thirty-six patients undergoing laparoscopic colon resection randomly received either TEA or TAP with ropivacaine only. The primary endpoint was opioid requirement up to 48 h postoperatively. Intensity of pain, time to onset of bowel function, time to mobilization, postoperative complications, length of hospital stay, and patients’ satisfaction with pain management were also assessed.

Results
We observed a significant decrease in opioid consumption on the day of surgery with TEA compared with TAP block (30 mg vs 14 mg, p < 0.001). On the first two postoperative days (POD), the balance shifted to opioid consumption being smaller in the TAP group: on POD 1 (15.2 mg vs 10.6 mg; p = 0.086) and on POD 2 (9.2 mg vs 4.6 mg; p = 0.021). There were no differences in postoperative nausea/vomiting or time to first postoperative bowel movement between the groups. No direct blockade-related complications were observed and the length of stay was similar between TEA and TAP groups.

Conclusion
TEA is more efficient for acute postoperative pain than TAP block on day of surgery, but not on the first two PODs. No differences in pain management-related complications were detected.
Stochastic smoothing of point processes for wildlife-vehicle collisions on road networks
Authors: Borrajo M. I. , Comas C. , Costafreda-Aumedes S. , Mateu J. 
Published: September 2021

AbstractWildlife-vehicle collisions on road networks represent a natural problem between human populations and the environment, that affects wildlife management and raise a risk to the life and safety of car drivers. We propose a statistically principled method for kernel smoothing of point pattern data on a linear network when the first-order intensity depends on covariates. In particular, we present a consistent kernel estimator for the first-order intensity function that uses a convenient relationship between the intensity and the density of events location over the network, which also exploits the theoretical relationship between the original point process on the network and its transformed process through the covariate. We derive the asymptotic bias and variance of the estimator, and adapt some data-driven bandwidth selectors to estimate the optimal bandwidth. The performance of the estimator is analysed through a simulation study under inhomogeneous scenarios. We present a real data analysis on wildlife-vehicle collisions in a region of North-East of Spain.
Psychological distress after esophageal cancer surgery and the predictive effect of dispositional optimism: a nationwide population-based longitudinal study
Authors: Liu Yangjun , Pettersson Erik , Schandl Anna , Markar Sheraz , Johar Asif , Lagergren Pernilla 
Published: September 2021

Abstract
Purpose
To examine the trajectory of psychological distress from 1 to 2 years after esophageal cancer surgery, and whether dispositional optimism could predict the risk of postoperative psychological distress.

Methods
This Swedish nationwide longitudinal study included 192 patients who had survived for 1 year after esophageal cancer surgery. We measured dispositional optimism with the Life Orientation Test-Revised (LOT-R) 1 year post-surgery and psychological distress with the Hospital Anxiety and Depression Scale 1, 1.5, and 2 years post-surgery. Latent growth curve models were used to assess the trajectory of postoperative psychological distress and to examine the predictive validity of dispositional optimism.

Results
One year after surgery, 11.5% (22 of 192) patients reported clinically significant psychological distress, and the proportion increased to 18.8% at 1.5 years and to 25.0% at 2 years post-surgery. Higher dispositional optimism predicted a lower probability of self-reported psychological distress at 1, 1.5, and 2 years after esophageal cancer surgery. For each point increase in the LOT-R sum score, the odds of psychological distress decreased by 44% (OR, 0.56; 95% CI, 0.40 to 0.79).

Conclusion
The high prevalence and longitudinal increase of self-reported psychological distress after esophageal cancer surgery indicate the unmet demands for timely psychological screening and interventions. Measuring dispositional optimism may help identify patients at higher risk of developing psychological distress, thereby contributing to the prevention of postoperative psychological distress.
Uniqueness for linear integro-differential equations in the real line and applications
Authors: Felipe-Navarro Juan-Carlos 
Published: September 2021

AbstractIn this work we prove the uniqueness of solutions to the nonlocal linear equation $$L \varphi - c(x)\varphi = 0$$

L
φ
-
c
(
x
)
φ
=
0

in $$\mathbb {R}$$
R
, where L is an elliptic integro-differential operator, in the presence of a positive solution or of an odd solution vanishing only at zero. As an application, we deduce the nondegeneracy of layer solutions (bounded and monotone solutions) to the semilinear problem $$L u = f(u)$$

L
u
=
f
(
u
)

in $$\mathbb {R}$$
R
when the nonlinearity is of Allen–Cahn type. To our knowledge, this is the first work where such uniqueness and nondegeneracy results are proven in the nonlocal framework when the Caffarelli–Silvestre extension technique is not available. Our proofs are based on a nonlocal Liouville-type method developed by Hamel, Ros-Oton, Sire, and Valdinoci for nonlinear problems in dimension two.
How I do it: the trans-laminar, facet-joint sparing minimal invasive approach for ventral dural repair in spontaneous intracranial hypotension—a 2-dimensional operative video
Authors: Corniola Marco V. , Meling Torstein R. 
Published: September 2021

Abstract
Background
We describe the minimally invasive, facet-sparing postero-lateral approach to the thoracic spine for a ventral dural repair in a patient with intracranial hypotension secondary to a spontaneous dural breach.

Methods
We performed a minimally invasive approach using a short paramedian posterior skin incision followed by a 10 × 10 mm targeted trans-laminar approach, to achieve a microsurgical repair of a symptomatic ventral dural defect causing severe disability.

Conclusion
The facet-sparing postero-lateral approach is safe and effective in the surgical management of thoracic dural tears, even in the most anterior ones, and avoids the traditional costotransversectomy.
Systematic review and meta-analysis of diagnostic studies of proximal surface caries
Authors: Janjic Rankovic Mila , Kapor Svetlana , Khazaei Yegane , Crispin Alexander , Schüler Ina , Krause Felix , Ekstrand Kim , Michou Stavroula , Eggmann Florin , Lussi Adrian , Huysmans Marie-Charlotte , Neuhaus Klaus , Kühnisch Jan 
Published: September 2021

Abstract
Aim
This systematic review and meta-analysis aimed to assess the diagnostic accuracy and reliability of commonly used caries detection methods for proximal caries diagnostics. Visual examination (VE), bitewing radiography (BWR), laser fluorescence (LF), and fibre-optic transillumination (FOTI) were considered in detail.

Material and methods
PRISMA guidelines for the reporting of systematic reviews and meta-analyses were applied. The mnemonic PIRDS (problem, index test, reference test, diagnostic and study type) concept was used to guide the literature search. Next, studies that met the inclusion criteria were stepwise selected and evaluated for their quality with a risk of bias (RoB) assessment tool. Studies with low/moderate bias and sufficient reporting were considered for meta-analysis. The pooled sensitivity (SE), specificity (SP), diagnostic odds ratio (DOR), and area under the ROC curve (AUC) were calculated.

Results
From 129 studies meeting the selection criteria, 31 in vitro studies and five clinical studies were finally included in the meta-analysis. The AUC values for in vitro VE amounted to 0.84 (caries detection) and 0.85 (dentin caries detection). BWR ranged in vitro from 0.55 to 0.82 (caries detection) and 0.81–0.92 (dentin caries detection). LF showed higher AUC values for overall caries detection (0.91) and dentin caries detection (0.83) than did other methods. Clinical data are limited.

Conclusion
The number of diagnostic studies with low/moderate RoB was found to be low and indicates a need for high-quality, well-designed caries diagnostic studies.

Clinical relevance
BWR and LF showed good diagnostic performance on proximal surfaces. However, because of the low number of includable clinical studies, these data should be interpreted with caution.
Apportioning deformation among depth intervals in an aquifer system using InSAR and head data
Authors: Smith Ryan G. , Hashemi Hossein , Chen Jingyi , Knight Rosemary 
Published: September 2021

AbstractLand surface subsidence due to excessive groundwater pumping is an increasing concern in California, USA. Interferometric Synthetic Aperture Radar (InSAR) is a remote sensing technique for measuring centimeter-to-millimeter surface deformation at 10–100 m spatial resolution. Here, a data-driven approach that attributes deformation to individual depth intervals within an aquifer system by integrating head data acquired from each of three screened intervals in a monitoring well with InSAR surface deformation measurements was developed. The study area was the Colusa Basin in northern Central Valley. To reconstruct the surface deformation history over the study area, 13 ALOS-PALSAR scenes acquired between 2006 and 2010 were processed. Up to ~3-cm year−1long-term subsidence and up to ~6 cm seasonal subsidence were observed using the InSAR technique. The technique developed in this paper integrates the InSAR-observed seasonal deformation rate and the co-located head measurements in multiple depth intervals to estimate the elastic skeletal storage coefficient, the time delay between the head change and the observed deformation, and subsequently the deformation of each depth interval. This technique can be implemented when hydraulic head measurements within each depth interval are not correlated with each other. Using this approach, the depth interval that contributed the most to the total subsidence, as well as storage parameters for all intervals, are estimated. The technique can be used for identification of the depth interval within the aquifer system responsible for deformation.
Exploration of predictors of benefit from nivolumab monotherapy for patients with pretreated advanced gastric and gastroesophageal junction cancer: post hoc subanalysis from the ATTRACTION-2 study
Authors: Kang Yoon-Koo , Morita Satoshi , Satoh Taroh , Ryu Min-Hee , Chao Yee , Kato Ken , Chung Hyun Cheol , Chen Jen-Shi , Muro Kei , Kang Won Ki , Yeh Kun-Huei , Yoshikawa Takaki , Oh Sang Cheul , Bai Li-Yuan , Tamura Takao , Lee Keun-Wook , Hamamoto Yasuo , Kim Jong Gwang , Chin Keisho , Oh Do-Youn , Minashi Keiko , Cho Jae Yong , Tsuda Masahiro , Sameshima Hiroki , Chen Li-Tzong , Boku Narikazu 
Published: September 2021

Abstract
Background
The phase 3 ATTRACTION-2 study demonstrated that nivolumab monotherapy was superior to placebo for patients with pretreated advanced gastric or gastroesophageal junction cancer, but early progression of tumors in some patients was of concern.

Methods
This post hoc analysis statistically explored the baseline characteristics of the ATTRACTION-2 patients and extracted a single-factor and double-factor combinations associated with early disease progression or early death. In the extracted patient subgroups, the 3-year restricted mean survival times of progression-free survival and overall survival were compared between the nivolumab and placebo arms.

Results
Two single factors (age and peritoneal metastasis) were extracted as independent predictors of early progression, but none of them, as a single factor, stratified patients into two subgroups with significant differences in restricted mean survival time. In contrast, two double-factor combinations (serum sodium level and white blood cell count; serum sodium level and neutrophil–lymphocyte ratio) stratifying patients into two subgroups with significant differences in the restricted mean survival time were extracted. Additional exploratory analysis of a triple-factor combination showed that patients aged < 60 years with peritoneal metastasis and low serum sodium levels (approximately 7% of all patients) might receive less benefit from nivolumab, and patients aged ≥ 60 years with no peritoneal metastasis and normal serum sodium levels might receive higher benefit.

Conclusions
A combination of age, peritoneal metastasis, and serum sodium level might predict benefit from nivolumab as salvage therapy in advanced gastric or gastroesophageal junction cancer patients, especially less benefit for patients having all three risk factors.
Understanding strategy assessment in IS management
Authors: Mueller Benjamin , Urbach Nils 
Published: September 2021

AbstractIn our research, we suggest a process theory for explaining the strategy assessment process and its effect in information systems (IS) planning. The proposed theory is derived from an analysis of practitioners and the practices they employ. Based on a multiple-case study design, we look at the IS management teams of three corporate IS departments and how they prepare for strategy development. The analysis of the projects reveals a stable pattern of activities employed by the three teams to assess their departments’ strategic positions and existing strategy. Along with this procedural understanding, our research also produces a detailed look at the outcomes of these managerial practices.