bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstate Sequence Theory of Phase Transition: Theory Construction and Application on 3‐Dimensional Ising Model
Authors: Ren Yikun , Xu Feixiang , Lin Ming , Hua Qiongxin 
Published: December 2024

AbstractThe concepts of microstates and statistical ensembles form a fundamental starting point for various statistical physics theories that address thermodynamic and phase transition behaviors of correlated many‐body systems. In this paper, we propose microstate sequence (MSS) theory built on a novel idea of arranging all microstates of a discrete thermodynamic system into a sequence with monotonically increasing property of key parameters and strict “smooth structure variation” property. Because of the properties, it obtains better analytical ability to express the derivation with the essential parameter change (in the cubic Ising model, the parameter is the dimensionality) at any micro‐structure to figure out the qualitative issues like the relationship between phase transition order and dimensionality. With this idea in mind, the microstate sequence (MSS) of the Ising model in arbitrary dimension is constructed through a nontrivial iteration method based on a series of number‐theoretic transformation tricks. After obtaining the complete form of the MSS for the Ising model, we provide a concise proof of the second‐order phase transition nature for the Ising model in all n 2 dimensions starting from the well‐known exact result for the two‐dimensional Ising model, as a test of the qualitative issue of MSS theory. Finally, we discuss the MSS theory in other lattice models like the Potts model and temperature derivation model to explore the correlations of number theory and phase trajectory in an extended range of discrete thermodynamic systems.
Exploring the Complex Mechanisms of Isoflavones: From Cell Bioavailability, to Cell Dynamics and Breast Cancer
Authors: Ferriere François , Aasi Nagham , Flouriot Gilles , Pakdel Farzad 
Published: December 2024

ABSTRACTIn Western countries, the increase in the consumption of soy‐derived products raises the population's exposure to isoflavones. These molecules, present in many foods, have numerous effects on the body's cells, including regulation of the transcription and epigenetics, cell signaling, cell cycle, cell growth, apoptosis, and oxidative stress. However, despite the multitude of studies conducted, on these compounds, it remains difficult to draw definitive conclusions regarding their safety or dangerousness in the diet. Indeed, some epidemiological studies highlight health benefits in consuming isoflavone‐rich foods, notably by reducing the risk of certain cancers. However, several studies conducted on cell models show that these molecules can have negative effects on cell fate, particularly with regard to proliferation and survival of mammary tumor cells. Isoflavones are mainly genistein, daidzein, formononetin, and biochanin A. These molecules belong to the family of phytoestrogens, which are capable of interacting with both nuclear estrogen receptor, ERα and ERβ, to trigger agonistic and antagonistic effects. Due to their estrogenic properties, isoflavones are suspected to promote hormone‐dependent cancers such as breast cancer. This suspicion is based primarily on their ability to bind to ERα in breast cells, thereby altering the signaling pathways that control cell growth. However, study results are sometimes contradictory. Some studies suggest that isoflavones may protect against breast cancer by acting as selective estrogen receptor modulators, while others highlight their potential role in stimulating tumor growth. This review explores the literature on the effects of isoflavones, focusing on their influence on ERα‐dependent signaling in breast tumor cells.
Model Mis‐Specification Analysis for Random Effect and Covariate Based on Wiener Degradation Process
Authors: Chen Tianyu , Jiang Deyin , Wang Keke , Jiang Senke , Cui Weimin 
Published: December 2024

ABSTRACTThanks to the extensive applications of accelerated degradation tests (ADT), the influence of covariates has been paid more and more attention. We propose a power‐law form, which is studied with other previously perceived covariate types for model uncertainty not neglecting unidentified distribution of drift parameter. It simultaneously determines the distribution of volatility parameters under Wiener process (WP) when the dependency inner model's parametric space exists. The Markov Chain Monte Carlo (MCMC) algorithm implemented by WinBUGS is employed to deal with general failure possibility functions of multiple hypothesis combinations. A new criterion aimed at measuring the volatility variable's goodness‐of‐fit is involved a company with several Akaike information criterion (AIC)‐like indexes for an overall model comparison and selection. It is convincing that after several numerical and real example analyses, the interaction between the covariate and latent variable distribution influences the performance of computation to a large degree.
Raman Imaging of Targeted Drug Delivery with DNA‐Based Nano‐Optical Devices
Authors: Tanwar Swati , Date Siddhi , Goel Linika , Wu Lintong , Chatterjee Arnab , Barman Ishan 
Published: December 2024

AbstractRaman spectroscopy (RS) has emerged as a novel optical imaging modality by identifying molecular species through their bond vibrations, offering high specificity and sensitivity in molecule detection. However, its application in intracellular molecular probing has been limited due to challenges in combining vibrational tags with functional probes. DNA nanostructures, known for their high programmability, have been instrumental in fields like biomedicine and nanofabrication. So far, their ability to customize Raman signals remains largely untapped. In this study, a new class of Raman active DNA origami‐based hybrid nanodevice (ND) for targeted cancer cell drug delivery and imaging is engineered. The ND is specifically engineered for metastatic prostate cancer treatment, featuring a legumain enzyme‐responsive sequence for the controlled release of the chemotherapeutic agent doxorubicin. Integrating RS with precise targeting, the ND enables imaging of aggressive cancer cells and efficient drug delivery with minimal off‐target effects. The developed device offers stimuli‐responsive behavior, enhanced stability, exceptional tunability, and potent targeting abilities, positioning it as a highly promising strategy for advancing precision cancer imaging and therapy.
N, S‐Rich SEI Derived From Continuously‐Releasing Additive for Anode‐Free Lithium‐Metal Batteries in Commercial Carbonate Electrolyte
Authors: Jiang Ruining , Zhu Zhenglu , Qi Xiaoqun , Yang Fengyi , Du Haoran , Ji Jie , Zhang Renyuan , Liu Zhikang , Qie Long 
Published: December 2024

AbstractFeatured with the highest possible energy density, anode‐free lithium‐metal batteries (AFBs) are still challenged by the fast capacity decay, especially for the ones operated in commercial carbonate electrolytes, which can be ascribed to the poor stability and continual broken/formation of the solid‐electrolyte interface (SEI) formed on the anode side. Here, sacrificial additives, which have low solubility in carbonate electrolytes and can be continuously released, are proposed for AFBs. The sacrificial and continuously‐releasing feature gifts the additives the capability to form and heal the SEI during the long‐term cycling process, thus minimizing the loss of active Li and enabling the AFLMBs with high loading LiNi0.8Co0.1Mn0.1O2 (21.7 mg cm−2) cathode a high capacity‐retention of 68.9% after 50 cycles in commercial carbonate electrolyte, in contrast to the control cell failed after 30 cycles. This work presents a simple and potential strategy for the practical applications of AFLMBs.
In Situ Transmission Electron Microscopy of Electrocatalyst Materials: Proposed Workflows, Technical Advances, Challenges, and Lessons Learned
Authors: Abdellah Ahmed M. , Salem Kholoud E. , DiCecco Liza‐Anastasia , Ismail Fatma , Rakhsha Amirhossein , Grandfield Kathryn , Higgins Drew 
Published: December 2024

AbstractIn situ electrochemical liquid phase transmission electron microscopy (LP‐TEM) measurements utilize micro‐chip three‐electrode cells with electron transparent silicon nitride windows that confine the liquid electrolyte. By imaging electrocatalysts deposited on micro‐patterned electrodes, LP‐TEM provides insight into morphological, phase structure, and compositional changes within electrocatalyst materials under electrochemical reaction conditions, which have practical implications on activity, selectivity, and durability. Despite LP‐TEM capabilities becoming more accessible, in situ measurements under electrochemical reaction conditions remain non‐trivial, with challenges including electron beam interactions with the electrolyte and electrode, the lack of well‐defined experimental workflows, and difficulty interpreting particle behavior within a liquid. Herein a summary of the current state of LP‐TEM technique capabilities alongside a discussion of the relevant experimental challenges researchers typically face, with a focus on in situ studies of electrochemical CO2 conversion catalysts is provided. A methodological approach for in situ LP‐TEM measurements on CO2R catalysts prepared by electro‐deposition, sputtering, or drop‐casting is presented and include case studies where challenges and proposed workflows for each are highlighted. By providing a summary of LP‐TEM technique capabilities and guidance for the measurements, the goal is for this paper to reduce barriers for researchers who are interested in utilizing LP‐TEM characterization to answer their scientific questions.
Graphene Oxide/Zinc Phthalocyanine Selective Singlet Oxygen Visible‐Light Nanosensor for Raman‐Inactive Compounds
Authors: Zvyagina Alexandra I. , Shiryaeva Olga A. , Afonyushkina Evgenia Yu. , Kapitanova Olesya O. , Averin Alexey A. , Kormschikov Ilya D. , Martynov Alexander G. , Gorbunova Yulia G. , Veselova Irina A. , Kalinina Maria A. 
Published: December 2024

AbstractA novel phthalocyanine‐based hybrid nanofilm is for the first time successfully applied as an oxidative platform for surface enhanced Raman spectroscopy (SERS) sensing to fine‐resolve Raman‐inactive compounds. The hybrid is formed by self‐assembly of zinc(II) 2,3,9,10,16,17,23,24‐Octa[(3′,5′‐dicarboxy)‐phenoxy]phthalocyaninate (ZnPc*) with the solid‐supported monolayer of graphene oxide (GO) mediated by zinc acetate metal cluster. Atomic force microscopy, UV–vis and fluorescence spectroscopies confirm that this simple coordination motive in combination with molecular structure of ZnPc* prevents contact quenching of the light‐excited triplet state through aromatic stacking with GO particles. Fluorescence probing with Sensor Green and terephthalic acid as specific indicators of active oxygen intermediates shows that the hybrid nanofilm initiates selective singlet oxygen generation under visible light. Direct one‐electron oxidation of tetramethylbenzidine (TMB) (1.0×10−7 m) on the hybrid surface in the presence of 100 nm silver nanoparticles as plasmonic hot‐spots under 450–640‐nm light irradiation yields well‐resolved resonance Raman spectrum of the oxidized form TMB+1. Using these hybrid nanofilms as visible light platforms for redox reaction of target analytes without additional oxidizing agents, the range of Raman‐detectable compounds can be significantly expanded through a rapid ultrasensitive SERS screening of substances currently considered Raman‐inactive.
Effectiveness and Treatment Persistence of Vedolizumab Compared to Anti‐Tumour Necrosis Factor‐α in Patients With Crohn's Disease: A Systematic Literature Review and Meta‐Analysis
Authors: Armuzzi Alessandro , Vermeire Séverine , Chaparro María , Biedermann Patricia , Brown Rebecca , McStravick Megan , Meyer Marlies , Schreiber Stefan 
Published: December 2024

ABSTRACTBackgroundVedolizumab is approved for the treatment of moderately to severely active Crohn's disease (CD). Real‐world evidence is essential for understanding the effectiveness and benefit–risk profile of vedolizumab outside clinical trial settings.ObjectiveTo identify, systematically review and assess the real‐world effectiveness and treatment persistence of vedolizumab in patients with CD, particularly over long‐term follow‐up periods and among populations with differing treatment experience, and to compare with the treatment persistence of anti‐tumour necrosis factor (TNF)‐α treatment.MethodsLiterature searches were conducted to identify studies published from 2014 to 2022. Relevant congress searches were conducted (2015–2022) using Embase or by hand. Data on adults with CD treated with vedolizumab or anti‐TNFα treatment in a real‐world setting were extracted for meta‐analysis.ResultsData from 73 studies, including 29,894 patients with CD, reported ≥ 1 outcome of interest for this analysis. Vedolizumab treatment persistence rate was 65.3% (95% confidence interval [CI] 60.2–70.1) at 1 year and 54.8% (95% CI 43.9–65.3) at 2 years. The treatment persistence rate with vedolizumab versus anti‐TNFα treatment was 84.6% (95% CI 70.2–92.8) versus 75.3% (95% CI 69.7–80.2) at 1 year and 70.6% (95% CI 60.7–78.8) versus 64.6% (95% CI 56.7–71.8) at 2 years. The mucosal healing rate at 1 year was 40.6% (95% CI 34.2–47.3). Clinical remission rates were 39.4% (95% CI 33.9–45.1) at 1 year and 34.3% (95% CI 18.1–55.2) at 2 years. Corticosteroid‐free clinical remission rates were 33.2% (95% CI 28.5–38.3) at 1 year and 20.4% (95% CI 12.5–31.5) at 2 years. All clinical outcome rates were higher in biologic‐naive than in biologic‐experienced patients.ConclusionReal‐world use of vedolizumab was associated with favourable long‐term effectiveness and treatment persistence. Vedolizumab is a suitable first‐line biological option for biologic‐naive patients with CD.
Update on Autoimmune Pancreatitis and IgG4‐Related Disease
Authors: Lanzillotta Marco , Vujasinovic Miroslav , Löhr Johannes‐Matthias , Della torre Emanuel 
Published: December 2024

ABSTRACTAutoimmune pancreatitis is an increasingly recognized inflammatory type of subacute pancreatitis; two subtypes of autoimmune pancreatitis have been identified so far: the “lymphoplasmacytic” type 1 variant and the “neutrophilic” type 2 variant. Type 1 autoimmune pancreatitis represents the most common manifestation of IgG4‐related disease, a fibro‐inflammatory disorder characterized by elevated IgG4 levels in the serum and affected tissues. Type 2 autoimmune pancreatitis is a pancreas‐specific disorder that frequently occurs in the context of inflammatory bowel diseases. Due to the complexity of both diseases, a comprehensive work up with imaging, laboratory, and histological studies is required to achieve a diagnosis and rule out malignancies. Glucocorticoids represent the cornerstone of the treatment, often supported by other immunosuppressive drugs in case of steroid intolerance or aggressive disease. Maintenance treatment is often employed in type 1 autoimmune pancreatitis because of the higher relapse rate compared with type 2 autoimmune pancreatitis. In this review, we summarize the key concept of autoimmune pancreatitis, delve into the differential diagnosis between the two subtypes, and cover the recent relevant research findings and pressing unmet needs.
Conclusions and Reflections: The Tapestry of Energy Citizenship Can (and Should) Be Woven by All
Authors: Vadovics Edina , Hajdinjak Marko , Thalberg Karin , Lydon Michael , Fahy Frances 
Published: December 2024

AbstractThis concluding chapter presents the rich tapestry of energy citizenship in Europe. It offers a summary and reflection on the various contexts and conditions for an emerging energy transition identified throughout the previous chapters. Across eight national settings, Belgium, Bulgaria, France, Germany, Hungary, Ireland, Latvia, and the Netherlands, many forms of energy citizenship were identified. These include individual and collective, and reformative and transformative forms. This chapter also reflects on the reality that the term “energy citizenship” is not (yet) widely known despite the many forms of it that flourish. The authors, themselves based in eight European countries, have highlighted case studies demonstrating exciting opportunities as well as considering the barriers different forms of energy citizenship encounter in various countries. In concluding this chapter, the authors ask So, what next for Energy Citizenship? and outline a summary of the ways in which energy citizenship initiatives can be supported and further developed. In addition, they highlight the significance of the overall research in providing opportunities to learn from the variety of energy citizenship that is prevalent across Europe. This collection concludes with a final reflection by the authors on the contribution of the overall collection and affirms the importance of sharing national and local experiences and showing case studies of energy citizenship.
For and By Citizens: The Various Faces of Energy Citizenship in Germany
Authors: Debourdeau Ariane , Schäfer Martina 
Published: December 2024

AbstractSince the term Energiewende (energy transition) was coined in the early 1980s, Germany has often been seen as a pioneer in the transition towards an energy system based on renewable energy sources. However, to what extent is the German energy transition linked to the environmental and anti-nuclear movements of the 1980s and shaped by different forms of energy citizenship? Beyond the strong support it receives from a large part of the population, the energy transition encompasses highly diversified faces of citizen involvement. Our empirical investigation of energy citizenship in Germany underlines the key role of engaged individuals (or groups of individuals) in promoting both energy democracy and citizenship by enabling and empowering other citizens to be part of the energy transition in various ways and scales. The latter addresses a large range of issues, from energy saving to renewable energy production and sustainable mobility. The outcome orientation of energy citizenship initiatives differs between rather reformative approaches that try to improve the current energy system and more transformative approaches that question current structures and aim to create a more decentralised, democratic and just energy system. This chapter presents insights into the diversity of forms of energy citizenship in Germany and the legal and political context in which they operate.
The Evolution of Energy Citizenship in the Netherlands: From Protest to Partnership with Business and Government
Authors: Kemp René , Markantoni Marianna , Zomerplaag Job , Pel Bonno , Crighton Ali 
Published: December 2024

AbstractThis chapter traces the dynamic history of energy citizenship in the Netherlands, an evolution from grassroots protests to partnerships with businesses and government entities. Through a comprehensive analysis of historical events, case studies, and policy developments, the study shows how energy citizenship in the Netherlands has evolved from opposition to nuclear power in the early 1970s to today’s diverse and multifaceted initiatives. The research employs a mix of qualitative methods, including interviews, document analysis, and workshops, focusing on Dutch energy citizenship initiatives such as Weert Energie, Ameland, LSA, and Loenen Energie. These examples not only showcase transformative goals and agency but also reflect the Poldermodel, a consensus-based decision-making process prevalent in the Netherlands characterised by collaboration and negotiation between multiple stakeholders, including the government, employers, labour unions, and other relevant parties. The paper also examines the role of intermediaries in enhancing energy citizenship and how changing power dynamics and institutional structures have influenced the energy transition. By comparing the rise and nature of energy cooperatives from the 1980s to the present day, the study highlights significant shifts in citizen engagement, technological adoption, and policy influence. The findings reveal that while energy citizenship in the Netherlands has achieved notable successes, it continues to navigate complex challenges in pursuit of a more sustainable and democratic energy future.
Documentation and Publication of Hypothetical Virtual 3D Reconstructions in the CoVHer Project
Authors: Bajena Igor Piotr , Apollonio Fabrizio Ivan , Argasiński Karol , Fallavollita Federico , Foschi Riccardo , Franczuk Jakub , Koszewski Krzysztof , Kuroczyński Piotr , Lutteroth Jan 
Published: December 2024

Abstract
The CoVHer Erasmus+ project addresses the long-standing lack of standardisation in hypothetical virtual 3D reconstruction and modelling in architectural heritage research. It aims to develop best practices for the 3D reconstruction of lost or never-built architectural heritage, enhancing research quality, transparency, and reusability. The collaborative effort includes contributions from five European universities and two private companies, focusing on architecture, archaeology, digital humanities, and art history. The presented workflow of documentation is the result of the joint effort in extensions of the approaches of the Scientific Reference Model (SRM) and Critical Digital Model (CDM), which strive for faithful reconstruction, documenting all decisions and inferences and advocate open licensing and use of non-proprietary formats to promote accessibility and reusability. The developed methodology aims to provide tools for the scientific evaluation of hypothetical reconstructions and support data exchange between researchers.
Integrating Paradata, Metadata, and Data for an Effective Memory Twin in the Field of Digital Cultural Heritage
Authors: Ioannides Marinos , Karittevli Elena , Panayiotou Panayiotis , Baker Drew 
Published: December 2024

Abstract
The extension of the concept of Digital Twin to Memory Twin offers an innovative approach to preserving and interacting in the field of Digital Cultural Heritage. This paper explores the integration of paradata, metadata and data to construct an effective Memory twin, providing a representation of cultural heritage. Paradata, together with metadata and data, greatly enriches the digital representation of cultural assets. By integrating these layers of information, we aim to develop a framework that enhances the preservation, accessibility and interpretability of digital cultural heritage. This approach enables advanced archival practices, personalised user experiences and improved data authenticity. Through case studies, we demonstrate the potential of this methodology to transform the management and dissemination of cultural heritage in the digital future.