bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demethylbelamcandaquinone B from Marantodes pumilum var. alata (Blume) Kuntze inhibits osteoclast differentiation in RAW264.7 cells
Authors: Ahmad Hairi Haryati , Jamal Jamia Azdina , Aladdin Nor Ashila , Husain Khairana , Mohd Sofi Noor Suhaili , Mohamed Norazlina , Mohamed Isa Naina , Shuid Ahmad Nazrun 
Published: December 2021

Objective:
To investigate the bone-resorbing effect of demethylbelamcandaquinone B (Dmcq B) extracted from Marantodes pumilum var. alata on osteoclast differentiation in RAW264.7 cells.

Methods:
RAW264.7 macrophages were differentiated using RANKL into osteoclast-like cells. Then, they were treated with 10 μg/mL Marantodes pumilum var. alata crude aqueous extract, 5 μg/ mL dichloromethane fraction, and 0.6 μg/mL Dmcq B and 0.06 μg/ mL estradiol. Tartrate-resistant acid phosphatase 5b (TRACP 5b) as an osteoclast phenotypic marker was determined by TRACP staining and TRACP 5b colometric assay, and bone-resorbing pits were examined. The gene expression of pro-inflammatory cytokines (TNF-α and IL-6) was measured. Moreover, the protein expressions of pro-inflammatory cytokines (TNF-α and IL-6) and estrogen receptors were evaluated.

Results:

Marantodes pumilum var. alata crude aqueous extract and Dmcq B inhibited RANKL-stimulated osteoclast differentiation as evidenced by size reduction of giant multinucleated osteoclast cells, decreased TRACP 5b activity as well as the subsiding of resorbed pit area compared with normal control. In addition, they reduced the gene and protein expressions of TNF-α and IL-6. Marantodes pumilum var. alata, Dmcq B, and estradiol treatments increased the protein expressions of estrogen receptors alpha and beta in osteoclasts.

Conclusions:

Marantodes pumilum var. alata and its active compound, Dmcq B can inhibit osteoclast differentiation.
Success Is Not Final, Failure Is Not Fatal
Authors: Hsu Chiun 
Published: December 2021

Objective:
To review the history of development of systemic therapy for advanced hepatocellular carcinoma (HCC).

Data Sources:
Published clinical trials of single-agent targeted agents, single-agent immune checkpoint inhibitors (ICI), and ICI-based combination regimens.

Results:
Key lessons learned from previous positive and negative clinical trials included design of more efficient clinical trials and incorporation of trial endpoints most relevant to clinical benefit. Major challenges included prioritization of novel combination therapies for clinical trials and development of predictive biomarkers.

Conclusion:
The improved efficacy and safety of systemic therapy will impact on future multi-disciplinary management of HCC through more extensive integration with liver-directed therapy for different stages of HCC patients.
Factors motivating nurses to work during Hajj pilgrimage in Saudi Arabia
Authors: AlKarani Ahmed Saleh 
Published: December 2021

Context:
Every year the Ministry of Health in Saudi Arabia announces the opening of applications to those who wish to work on Hajj. A certain number of applicants are nominated, yet many nurses continue to apply to participate during Hajj ever year. Although nurses are under great work pressure during Hajj, many nurses still apply for the approval to participate in Hajj.

Aims:
The aim of this study is to identify the motivations of nurses to work during Hajj. Furthermore, to explore the motivations that lead nurses to participate in the Hajj season and to explore the challenges faced during the Hajj season.

Settings and Design:
The study used a descriptive qualitative study design. Twelve nurses participated in this study from Mina hospitals in Makkah, Saudi Arabia.

Subjects and Methods:
In-depth semi-structured interview with 12 nurses. Data were collected from November 2020 to January 2021.

Statistical Analysis Used:
The data were analyzed using the thematic analysis.

Results:
This study showed four themes motivating nurses to participate in Hajj: taking part in Hajj is an honor and they are proud of it; great rewards will be received from ALLAH; team spirit; and the fact that it is a good experience. This study also showed two of challenges that nurses face in Hajj which are pilgrims' low awareness and language barriers.

Conclusions:
The stakeholder should consider these themes and reinforce them to show to all nurses, as this may increase the quality of the applicants asking to work as nurses in Hajj.
A study to assess the level of anxiety and stress among health-care professionals during the early stage of COVID-19 outbreak in Bangladesh
Authors: Ahmed Sohel , Rahman Md Matiur , Islam Md Nazrul , Akter Rahemun , Chowdhury Ahmed Raid 
Published: December 2021

Background:
The health-care professionals are at high risk of getting infection of COVID-19 due to the highly interactivity of the disease. The virulence of the disease causes huge stress among health-care professionals.

Aim:
Our study aimed to find out the level of stress and fear among health-care professionals due to COVID-19 outbreak in Bangladesh.

Materials and Methods:
A cross-sectional study was conducted by using a structured questionnaire containing demographic data, Fear of COVID-19 Scale (FCV-19S), Kessler Psychological Distress Scale, and factor causing stress. A total number of 146 participants, both male and female, were participated in this study. We utilized Google Platform to construct the questionnaire and virtual snowball sampling method to collect the data.

Results:
The mean age, height, and weight of the participants were 27.52 ± 6.10, 162.53 ± 10.67, and 64.75 ± 10.89, respectively. The mean score of Kessler Psychological Distress Scale was 23.57 ± 5.38, ranging from 27 to 38 and the mean score of FCV-19S was 24.27 ± 6.27, ranging from 7 to 35. The participants those who are living with their family are at significant level of stress (P = 0.041) that they can affect their family members.

Conclusion:
The health-care professionals are in highly stressed due to the COVID-19 outbreak. Stress management strategies should be taken as a preventive measure to overcome the further serious situation.
The Relationship of Knowledge of Pregnant Women to Compliance with Health Protocols During the Covid-19 Pandemic at the Kassi-Kassi Health Center Makassar in 2021
Authors: Rahman Nur indah noviyanti , Hukmiyah Aspar  , Gusriani  
Published: December 2021

Relationship of Knowledge of Pregnant Women to Compliance with Health Protocols during the COVID-19 Pandemic at Kassi-Kassi Health Center Makassar in 2021.
The purpose of this study was to determine the relationship between knowledge of pregnant women and adherence to health protocols during the COVID-19 pandemic at the Kassi-Kassi Health Center Makassar.
This study uses analytical research methods by carrying out a Cross Sectional Study approach to determine the relationship between knowledge of pregnant women and adherence to health protocols during the COVID-19 Pandemic at the Kassi-Kassi Health Center Makassar. With a population of pregnant women who perform ANC examinations at the Kassi-Kassi Health Center Makassar and the number of samples is 30 respondents using the Accidental Sampling technique.
From the results of statistical tests using the Chi-Square (Continuity Correction) test, the value of (0.039) < (0.050) is obtained, so Ha is accepted and H0 is rejected, this study shows that there is a relationship between knowledge of pregnant women and adherence to health protocols.
Making A Web-Based Application For Sales Kitchen Bunda Ghina Using Php And Mysql
Authors: Adam Huda Nugraha  
Published: December 2021

Mother Ghina's kitchen is located in Teluk Low Pasar Village, Tebo Ilir District, Jambi Province. When transacting, store sellers still use simple media for information delivery, such as WhatsApp, Facebook and word of mouth. The purpose of creating this application is to expand promotional media and make it easier for consumers from inside and outside the city to place orders online. In the process of creating the website using PHP programming language and Mysql as database. The final stage is to conduct a trial over the Internet.
Assessment of Human Factors Causes of Occupational Risk in the Chemical Industry Using the Analytic Network Process (ANP) Method
Authors: Patradhiani Rurry Patradhiani , Maimana  
Published: December 2021

The development of the industry in Indonesia is inseparable from the analysis of the production process and identification of the risk of causing work accidents. In every production process in the chemical industry there are various risks that cause occupational accidents, the biggest cause of accidents comes from human factors. It required a priority assessment of workplace accidents influence on the human factor as the cause of the rising incidence of labor in the production process in the chemical industry with the method of Analytic Network Process (ANP) , of the assessment results using ANP method can be determined to set a risk management strategy causes of accidents. ANP method is done by determining goals, criteria, and sub criteria. In this case the criteria are the production process and the sub criteria are human factors that cause the risk of work accidents. Furthermore, the value of influence between criteria is determined, between criteria and sub criteria and between sub-criteria . The results obtained are the highest limiting values for criteria, namely the final product process and sub-criteria, namely human factors not using PPE . Strategies that can be taken to control risk is by giving reward and punishment, providing HSE training, as well as the management is partially responsible for HSE
Optimize Thermal Management And Experiment Of Lifepo4 Battery Pack For Hybrid Electrical Vehicle
Authors: Abdul Muchlis  , Moh. Yamin  
Published: December 2021

Hybrid Electric Vehicles (HEV) combines the benefits of gasoline engines and electric motors which can be configured for improving fuel efficiency. Lithium Iron Phosphate (LiFePO4) Phosphate based technology possesses superior thermal and chemical stability which provides better safety characteristics than those of Lithium-ion technology made with other cathode materials. This research conducted by two methods , methods of part 1 is a comparison of the results with the thermal management simulation and experiment, part 2 is a method of optimizing the thermal management for battery pack by using solidwork software. When the fan is on, the forced air flow over the cells removes some of the generated heat. Results of method part 1 is simulation more heat than experiment in the amount of 0.11% – 1.56%. The results of the method part 2 is simulated using the fan 4 fan with a speed of 415 rad/s and battery gap 30mm most efficient compared with 4 fans the other , while the simulation using 6 fan, fan speed 415 rad/s and battery gap 30mm most efficient for all.
ACCOUNTING RECOGNITION OF ASSET ABANDONMENT AND SITE RESTORATION
Authors: Cahyanti Rena Maya , WIRJOLUKITO ARUNA 
Published: December 2021

<p><em>This research will discuss the recognition of asset abandonment and site restoration or commonly known as ARO (Asset Retirement Obligation) in oil and gas company. The purpose is to be able to provide an overview that can be used by companies in calculating ARO that must be paid at the end of the contract period. The formulation of the problem is which method is used to determining the amount of asset abandonment and site restoration or ARO that is appropriate to overcome the potential problems that arise at the end of the contract period. This research is carried out by using a mixed method in analyzing the findings, so it will find the in-depth findings which will be useful to assist the company's management in making decisions. Signal theory is a theory that will be chosen in this research. This research will use three stages of analysis, such as descriptive analysis, content analysis, and constant comparative analysis. Based on the results it might found that the recognition of asset abandonment and site restoration carried out according to regulations apply. While company uses the method of calculating liabilities based on future values that is continually calculate in present value.</em></p><p><em> </em></p><p><strong><em>Keywords:</em></strong><em> Contingent liabilities, provisions, liability for asset abandonment and site restoration</em></p>
Influence of Disclosure Corporate Social Responsibility Toward Sustainable Economic Development With Financial Performance as An Intervening Variable
Authors: Mamduh Muhammad Faizul , Agriyanto Ratno , Farida Dessy Noor 
Published: December 2021

<p><em> </em><em>Companies in carrying out their business have obligations to stakeholders in any form. CSR is one of the company's responsibilities for the activities carried out so far to the surrounding environment. In reality the CSR program has not been able to speak much in helping to improve the welfare of the community through sustainable development. This can be seen from the percentage of poverty in Indonesia that is still quite high. BPS noted that the highest poverty rate was in eastern Indonesia, namely the islands of Maluku and Papua with a percentage of 21.45%. This study aims to determine the effect of corporate social responsibility disclosure on sustainable economic development with financial performance as an intervening variable (an empirical study of mining companies listed on the 2016-2018 Syariah Securities List). The method used in this study is a quantitative method using the Warp PLS 4.0 application. The results of this study state that there is a significant influence and positive relationship between corporate social responsibility and sustainable economic development. There is a significant influence and positive relationship between corporate social responsibility and financial performance. And financial performance as an intervening variable significantly and positively influences between corporate social responsibility and sustainable economic development. </em></p>
Branding Strategy of West Java: Fashion Products of The Creative Industry
Authors: Rufaidah Popy 
Published: December 2021

<p><em>In past research, </em><em>branding strategy application in </em><em>the creative industry has been left largely unexplored. This study aims to investigate the types of </em><em>branding strategy elements perceived as the distinctiveness of West Java in fashion products of the creative industry. </em><em>Th</em><em>is</em><em> study </em><em>is a cross-sectional study using</em><em> survey method, which </em><em>i</em><em>s designed to </em><em>describe the frequency of customer perceptions of branding strategy elements such as products design, marketing communicationtools and physical environment. The data used in this study is primary and secondary data. The primary data is obtained from the results of observations, interviews and survey using questionnaires. The respondents of the study are the customers of fashion products in the creative industry who have been living in West Java at lest for two years. The study concludes that there are some critial points in building West Java brand through several branding strategy elements that need more attention such as (i) the performance of blogs and websites as marketing promotional tools used by companies in the creative industry is perceived low (37%); (ii) most of the fashion products marketed by companies in the creative industry are perceived similar and not unique (57%); (iii) the logo of the fashion products sold in the market by creative industry players is perceived not attractive (37%) and; the places where the fashion products are sold are perceived not clean (46%).</em></p><strong><em>Keywords: </em></strong><em>Branding Strategy, Fashion Products, Creative Industry</em>
ANALYSIS OF THE EFFECTS OF QUALITY WORK OF LIFE FACTORS ON EMPLOYEE MOTIVATION REGIONAL OFFICE OF UNIVERSITAS TERBUKA AT PANGKALPINANG, INDONESIA
Authors: Yusuf Yusuf , Sutawijaya Adrian 
Published: December 2021

<p><em>The purpose of this research is to know the description of Quality of Work Life and Employee Motivation in UPBJJ-UT Pangkalpinang, and its influence is partially and simultaneously so that it can get information to increase motivation which will improve the quality of organizational performance. The research method used is descriptive quantitative approach with cross sectional design. The sample in this study amounted to 30 samples. The type of data used is the primary data. Data analysis technique using multiple linear regression test. The results showed that (1) The overall variables had a high average value that is in the category of 3.41-4.20 and the variable of pride to the institution had the highest average value of 4.21%. Thus the majority of respondents feel proud of the institution while working at UPBJJ-UT Pangkalpinang. In general, there are seven variables that have positive and significant influence and four variables that have positive but not significant influence. Variables that have positive and significant impacts are available facilities, workplace safety, employee engagement, communication, security, a sense of pride in institutions and work restructuring. While the variables that have positive but not significant are balanced compensation, career development, problem solving and work environment (3) Simultaneously the Quality of Work Life variable has a positive and significant influence on work motivation. This means that any increase or decrease in Quality of Work Life together will give a significant influence on employee motivation in UPBJJ-UT Pangkalpinang.</em></p><p><em> </em></p><p><em>Keywords: Quality of Work Life, Work Motivation, and Employee Motivation</em></p>
Management of Janu Sandhigata Vata with Navaprasrutika Basti - A Case Study
Authors: Desai Shikha , Sonawane Nirmala Ramesh , Parappagoudra Mahesh , Thakur Kritika 
Published: December 2021

SandhigataVata may be a disease of the elderly persons. Life style, obesity, trauma and diet deficient in calcium are a number of the risk/causative factors. Rooksha Aahar and Ativyaama cause vitiation of Vata. It mainly affects weight-bearing joints of the body specially knee, hip, lumbar spine. Being commonest variety of articular disorders, SandhigataVata poses a large hindrance in day-to-day activities of the sufferer like walking, dressing and bathing etc. The common presentation of the disease is Shula, Sotha, Vata Poornadriti Sparsha and difficulty in flexion and extension of the Sandhi. Available treatment options include use of NSAID’s, calcium supplementation and ultimately joint replacement. Here during this case study, a 36-year-old patient with Janu SandhigataVata came to Parul Ayurved Hospital with complaints of Right knee joint pain, crackling sound in joints since 2 months. Due to long standing and straining, the patient had these symptoms. This Indoor patient was treated with Abhyanga at Nabhi, Parshva, Prushtha & Ubhaya pada Pradesh and Anuvasana with Murcchit Tila Taila and Navaprasrutik Basti for 10 days. The patient responded well to these Ayurvedic treatments and got relief from major symptoms.
Anticancer and antioxidant activity of ethanolic extract of Clove (Syzygium aromaticum) on oral squamous cell carcinoma cell lines (KB cell lines)- An In-vitro study
Authors: Sanikop Sheetal , Bhat Kishore , Kotrashetti Vijayalakshmi , Kumbar Vijay , Ammanagi Renuka , MR Peram 
Published: December 2021

Cloves (Syzygium aromaticum) as been used as traditional medicine for many years and they possess antibacterial, antifungal and antiviral properties. Clove is known for its anticancer property on various cancer cell lines and is well established, but its anticancer effect on OSCC cell lines is less known. Aim of the study was to determine the anticancer and antioxidant effect of Syzygium aromaticum extract on OSCC cell lines (KB cell lines) and compare the same with normal mouse fibroblasts cell lines (L292 cell lines). KB cell lines and L292 cell lines were commercially obtained. Clove was obtained from local market and ethanolic extract (EC) of clove was prepared. Anticancer activity was assessed by MTT, neutral red, DAPI and Double staining assay and antioxidant assay was carried out by FRAP, PM and DPPH assay. The antioxidant property of EC of clove increased with increase in the concentration in a dose dependent manner. Both MTT and Neutral Red assay showed increase in cell death with increase in concentration of EC of clove. Double staining and DAPI showed increase in cell death when treated with EC of clove. The anticancer and antioxidant activity of EC of clove was comparable with standard drug used in the assay. This in vitro study demonstrates effective anticancer and antioxidant activity on KB cell lines when compared to standard control. However, further studies are to be conducted in order to characterize other potential antitumor components of the clove, so that it can be used as therapeutic agent in treating oral carcinoma.
Pharmaceutico-analytical study of Praval Bhasma (Coral calax) with two different herbs
Authors: Dubewar Arati P , Londhe Uday , Kulkarni Medha S , Kakodkar Pradnya , Dashetwar Anupama R , Shete Ashwin Ashok 
Published: December 2021

Introduction: In the present study, Praval is used as a raw material to form Praval Bhasma. Praval (Coral) is the calcareous skeleton of the minute marine organism called Anthezoa polypus and belongs to phylum coelenterate. It is a natural source of rich calcium widely used in Deepan, Pachan, Amlapitta Raktapitta, Yakshma, Kasa, Netra Roga and Hridaya Roga (1)and Calcium deficiency diseases etc. it is administered in the form of Bhasma and Pishti. Method: Shodhan of Praval is done in Sarjika kshara. The Pravala bhasma is prepared by two different method by triturating it with Kumari Swaras and Guduchi Kashay and incineration in Muffle furnace. physico-chemical tests like Total Ash, Acid Insoluble Ash, Loss on Drying, and Qualitative analysis of praval bhasma by NPST (Namburi Phased Spot Test) are done. Result & conclusion: Praval bhasma prepared by two different medicines shows potency, efficacy for further clinical use.
Ayurvedic Management of Pakshaghata (Left Hemiplegia) – A Case study
Authors: Mohan Vishnu , B Divya , Deva Sachin 
Published: December 2021

Hemiplegia is the commonest manifestation of a Stroke with neurological deficit affecting the face, limbs and trunk on one side or either side of the body. Stroke is one of the leading causes of death and disability in India. The aggravated Vata paralyze one side of the body either right or left , leads to immobility is called as Pakshaghata. The present case study deals with a 63years old male patient with chief complaints weakness in left half of the body and was unable to walk. He was a diagnosed case of Haemorrhagic Stroke presenting with Left Sided Hemiplegia with Acute Intraparenchymal Haemorrhage in C.T. brain. The Ayurvedic diagnosis of Pakshaghata was made and managed with treatment principle which is mentioned by Acharya Charaka. Snehana, Swedana and Mridu Virechana along with Panchakarma procedures Shirodhara, Shiropichu and Basti for 21 days. Samshamana Aushadhis(Oral medicines) and Physiotherapy were adopted at various stages of the diseases. Maximum improvement was noticed in upper and lower extremity functions at the end of the treatment. Patient showed remarkable recovery in Speech ability and Mobility. Panchakarma is a minimal invasive Bio-Cleansing procedure which can be adopted in life style, metabolic, autoimmune diseases and also periodic healthy individual as preventive measures.