bluuebunny/crossref_metadata_2025_split huggingface dataset:
RIPTIDE: a novel recoil-proton track imaging detector for fast neutrons
Authors: Musumarra A. , Leone F. , Massimi C. , Pellegriti M.G. , Romano F. , Spighi R. , Villa M. 
Published: December 2021

Abstract
Neutron detectors are an essential tool for the development of many research fields, as nuclear, particle and astroparticle physics as well as radiotherapy and radiation safety. Since neutrons cannot directly ionize, their detection is only possible via nuclear reactions. Consequently, neutron-based experimental techniques are related to the detection of charged particle or electromagnetic radiation originating from neutron-induced reactions. The study of fast neutrons is often based on the neutron-proton elastic scattering reaction. In this case, the ionization induced by the recoil protons in a hydrogenous material constitutes the basic information for the design and development of neutron detectors. Although experimental techniques have continuously improved and refined, so far, proton-recoil track imaging is still weak in laboratory rate environments because of the extremely small detection efficiency. To address this deficiency, we propose a novel recoil-proton track imaging system in which the light deriving from a fast scintillation signal is used to perform a complete reconstruction in space and time of the event. In particular, we report the idea of RIPTIDE (RecoIl Proton Track Imaging DEtector): an innovative system which combines a plastic scintillator coupled to imaging devices, based on CMOS technology, or micro channel plate sensors. The proposed apparatus aims at providing neutron spectrometry capability by stereoscopically imaging the recoil-protons tracks, correlating the spatial information with the time information. RIPTIDE intrinsically enable the online analysis of the ionization track, thus retrieving the neutron direction and energy, without spoiling the overall efficiency of the detection system. Finally, the spatial and topological event reconstruction enables particle discrimination — a crucial requirement for neutron detection — by deducing the specific energy loss along the track.
Influence of B2O3 doping on synthesis of MgTiO3 ceramics from recycled magnesia-hercynite materials
Authors: Jia Xiaodong , Mao Shuo , Tian Lin , Chen Shujiang , Li Guohua , Gao Wei 
Published: December 2021

Abstract
Herein, magnesium metatitanate (MgTiO3) ceramics were synthesised using recycled magnesia-hercynite (MH) bricks as the raw materials to achieve solid waste reusing of cement kiln refractories. The recycled MH materials were mixed with anatase TiO2 to investigate the effect of addition of doped B2O3 during the synthesis of MgTiO3 ceramics at 1400 °C. Phase compositions and microstructural studies were performed using x-ray diffraction (XRD) and scanning electron microscope (SEM), respectively. In addition, energy-dispersive spectroscopy (EDS) was conducted and the dielectric properties of the samples were studied. Results show that the addition of B2O3 can promote sintering, improve shrinkage, promote densification, stabilise MgTiO3 lattice, and inhibit the formation of MgTiO3. In addition, the presence of appropriate amount of B2O3 can accelerate the material diffusion and result in grain growth through the formation of intercrystalline liquid phase. Results also suggest that an increase in dielectric constant results in a decrease in dielectric loss. It was concluded that 2 wt% was the optimum amount of B2O3 required to obtain the most favourable synthesis rate of MgTiO3 (98.2%). The samples exhibited a maximum density of 3.69 g·cm−3 and excellent microwave dielectric properties at ε
r = 18.28 and tanδ = 0.086.
Fabrication of superhydrophobic surface with corrosion resistance via cyclic chemical etching process on aluminum substrate
Authors: Lv Shuwei , Zhang Xinming , Yang Xiaodong , Liu Xianli , Yang Zhuojuan , Zhai Ying 
Published: December 2021

Abstract
Aluminum (Al) is a metal material commonly used in industry, but its surface is easily corroded. The superhydrophobic surface has great self-cleaning and anti-corrosion properties, and it is an ideal method to construct a functional aluminum surface. Here, a simple method based on cyclic chemical etching was proposed to achieve the superhydrophobic Al surface with honeycomb structures. The surface of the sample etched eight times comprised micro/nano-scale honeycomb cavities, while exhibiting a water contact angle (WCA) of 135°. After being treated with an octadecanethiol (C18H38S) methanol solution, this sample demonstrated a WCA of 153.1°. A self-cleaning test was performed on the superhydrophobic Al surface, showing the excellent self-cleaning property. Finally, the electrochemical anti-corrosion test demonstrated that the above-mentioned superhydrophobic Al surface had great corrosion resistance property. Overall, this work has enriched the theory and technology for fabricating aluminum to achieve superhydrophobic.
The size effect of martensite laths and precipitates on high strength wear-resistant steels
Authors: Xue Huan , Zhang Yansong , Zhu Min , Yin Xiyan , Zhang Wenqian , Liu Shengnan 
Published: December 2021

Abstract
Low alloy high strength wear resistant steels are with high toughness, low cost and good abrasion resistance. It can effectively resist the propagation of wear cracks and prolong the service life of machine components. This paper focuses on the internal relationship between macroscopic physical properties and microscopic martensite lath and precipitate size throughout thickness of wear resistant steel. Four kinds of 40mm thickness wear resistant steels with different alloy chemical composition were produced and investigated. Results show the strength and hardness performance of ARIV are obviously higher than other three steels. ARI have a relatively large strength difference through thickness. The impact toughness of ARIV is relatively uniform, which is greater than that of the ARIII at middle layer and lower than that of the ARIII at 1/4 layer. The width of martensite lath of ARIV is relatively small, mainly 100 ∼ 300 nm, while that of ARII and ARIII is mainly 200 ∼ 400 nm. ARIV steel has shorter martensite lath band and more precipitates below 50 nm. It indicates that the size of martensite laths and precipitates of wear-resistant steels are important factors to determine its performance throughout thickness.
Virtual monochromatic imaging reduces beam hardening artefacts in cardiac interior photon counting computed tomography: a phantom study with cadaveric specimens
Authors: Inkinen Satu I , Juntunen Mikael A K , Ketola Juuso , Korhonen Kristiina , Sepponen Pasi , Kotiaho Antti , Pohjanen Vesa-Matti , Nieminen Miika 
Published: December 2021

Abstract
In interior cardiac computed tomography (CT) imaging, the x-ray beam is collimated to a limited field-of-view covering the heart volume, which decreases the radiation exposure to surrounding tissues. Spectral CT enables the creation of virtual monochromatic images (VMIs) through a computational material decomposition process. This study investigates the utility of VMIs for beam hardening (BH) reduction in interior cardiac CT, and further, the suitability of VMIs for coronary artery calcium (CAC) scoring and volume assessment is studied using spectral photon counting detector CT (PCD-CT). Ex vivo coronary artery samples (N = 18) were inserted in an epoxy rod phantom. The rod was scanned in the conventional CT geometry, and subsequently, the rod was positioned in a torso phantom and re-measured in the interior PCD-CT geometry. The total energy (TE) 10–100 keV reconstructions from PCD-CT were used as a reference. The low energy 10–60 keV and high energy 60–100 keV data were used to perform projection domain material decomposition to polymethyl methacrylate and calcium hydroxylapatite basis. The truncated basis-material sinograms were extended using the adaptive detruncation method. VMIs from 30–180 keV range were computed from the detruncated virtual monochromatic sinograms using filtered back projection. Detrending was applied as a post-processing method prior to CAC scoring. The results showed that BH artefacts from the exterior structures can be suppressed with high (≥100 keV) VMIs. With appropriate selection of the monoenergy (46 keV), the underestimation trend of CAC scores and volumes shown in Bland-Altman (BA) plots for TE interior PCD-CT was mitigated, as the BA slope values were −0.02 for the 46 keV VMI compared to −0.21 the conventional TE image. To conclude, spectral PCD-CT imaging using VMIs could be applied to reduce BH artefacts interior CT geometry, and further, optimal selection of VMI may improve the accuracy of CAC scoring assessment in interior PCD-CT.
Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis
Authors: Badenoch James B. , Rengasamy Emma R. , Watson Cameron , Jansen Katrin , Chakraborty Stuti , Sundaram Ritika D. , Hafeez Danish , Burchill Ella , Saini Aman , Thomas Lucretia , Cross Benjamin , Hunt Camille K. , Conti Isabella , Ralovska Sylvia , Hussain Zain , Butler Matthew , Pollak Thomas A. , Koychev Ivan , Michael Benedict D. , Holling Heinz , Nicholson Timothy R. , Rogers Jonathan P. , Rooney Alasdair G. 
Published: December 2021

AbstractThe nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric symptoms in survivors of COVID-19. For this pre-registered systematic review and meta-analysis (PROSPERO ID CRD42021239750), we searched MEDLINE, EMBASE, CINAHL and PsycINFO to 20 February 2021, plus our own curated database. We included peer-reviewed studies reporting neuropsychiatric symptoms at post-acute or later time-points after COVID-19 infection and in control groups where available. For each study, a minimum of two authors extracted summary data. For each symptom, we calculated a pooled prevalence using generalized linear mixed models. Heterogeneity was measured with I2. Subgroup analyses were conducted for COVID-19 hospitalization, severity and duration of follow-up. From 2844 unique titles, we included 51 studies (n = 18 917 patients). The mean duration of follow-up after COVID-19 was 77 days (range 14–182 days). Study quality was most commonly moderate. The most prevalent neuropsychiatric symptom was sleep disturbance [pooled prevalence = 27.4% (95% confidence interval 21.4–34.4%)], followed by fatigue [24.4% (17.5–32.9%)], objective cognitive impairment [20.2% (10.3–35.7%)], anxiety [19.1% (13.3–26.8%)] and post-traumatic stress [15.7% (9.9–24.1%)]. Only two studies reported symptoms in control groups, both reporting higher frequencies in COVID-19 survivors versus controls. Between-study heterogeneity was high (I2 = 79.6–98.6%). There was little or no evidence of differential symptom prevalence based on hospitalization status, severity or follow-up duration. Neuropsychiatric symptoms are common and persistent after recovery from COVID-19. The literature on longer-term consequences is still maturing but indicates a particularly high prevalence of insomnia, fatigue, cognitive impairment and anxiety disorders in the first 6 months after infection.
User Experience (UX) Design as a co-design methodology: lessons learned during the development of a web-based portal for cardiac rehabilitation
Authors: Nesbitt Katie , Beleigoli Alline , Du Huiyun , Tirimacco Rosy , Clark Robyn A 
Published: December 2021

Abstract
Person-centred care advocates for co-design of all healthcare services and research interventions by the end-user. Co-design is widely used, but the methodological approaches, evaluation, and reporting of outcomes are often poorly defined. One methodology for co-design is the User Experience Design which provides guidance and theoretical frameworks to inform development and reporting measures. This article outlines the application of this approach in the development of a web-based cardiac rehabilitation program and reports on the very positive experiences of the patients involved in the process and how their input strategically influenced outcomes.
Radical and/or respectable: coverage of radical politics in The Times and the Manchester Guardian in interwar Britain
Authors: Ackerley Aaron 
Published: December 2021

Abstract
A major issue for campaigners for radical political programmes is the question of publicity. A vibrant literature has emerged examining the ways in which the Labour party developed a media strategy and cultivated their own newspapers and links with established media organizations in mid twentieth-century Britain. However, the role of the quality press in helping make the radical respectable in the interwar and Second World War period merits more attention. This article provides a detailed analysis of internal developments at The Times and the Manchester Guardian to explain how both papers came to promote radical policies.
Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population
Authors: Sonehara Kyuto , Sakaue Saori , Maeda Yuichi , Hirata Jun , Kishikawa Toshihiro , Yamamoto Kenichi , Matsuoka Hidetoshi , Yoshimura Maiko , Nii Takuro , Ohshima Shiro , Kumanogoh Atsushi , Okada Yukinori 
Published: December 2021

Abstract
Understanding the genetic effects on non-coding RNA (ncRNA) expression facilitates functional characterization of disease-associated genetic loci. Among several classes of ncRNAs, microRNAs (miRNAs) are key post-transcriptional gene regulators. Despite its biological importance, previous studies on the genetic architecture of miRNA expression focused mostly on the European individuals, underrepresented in other populations. Here, we mapped miRNA expression quantitative trait loci (miRNA-eQTL) for 343 miRNAs in 141 Japanese using small RNA sequencing and whole-genome sequencing, identifying 1275 cis-miRNA-eQTL variants for 40 miRNAs (false discovery rate &lt; 0.2). Of these, 25 miRNAs having eQTL were unreported in the European studies, including 5 miRNAs with their lead variant monomorphic in the European populations, which demonstrates the value of miRNA-eQTL analysis in diverse ancestral populations. MiRNAs with eQTL effect showed allele-specific expression (ASE; e.g. miR-146a-3p), and ASE analysis further detected cis-regulatory variants not captured by the conventional miRNA-eQTL mapping (e.g. miR-933). We identified a copy number variation associated with miRNA expression (e.g. miR-570-3p, P = 7.2 × 10−6), which contributes to a more comprehensive landscape of miRNA-eQTLs. To elucidate a post-transcriptional modification in miRNAs, we created a catalog of miRNA-editing sites, including 10 canonical and 6 non-canonical sites. Finally, by integrating the miRNA-eQTLs and Japanese genome-wide association studies of 25 complex traits (mean n = 192 833), we conducted a transcriptome-wide association study, identifying miR-1908-5p as a potential mediator for adult height, colorectal cancer and type 2 diabetes (P &lt; 9.1 × 10−5). Our study broadens the population diversity in ncRNA-eQTL studies and contributes to functional annotation of disease-associated loci found in non-European populations.
Relative growth and reproductive biology of females of Macrobrachium amazonicum (Heller, 1862) (Decapoda: Caridea: Palaemonidae) in the semiarid Northeast Region, Brazil
Authors: Ventura Emerson , Winick-Silva Allysson , Shinozaki-Mendes Renata A 
Published: December 2021

Abstract
We analyzed aspects related to the relative growth and reproduction of females of Macrobrachium amazonicum (Heller, 1862) in a population of the semiarid Northeast Region of Brazil. Carapace (CL) and total length (TL) ranged 5.57–17.61 mm (mean 10.96 ± 2.07 mm) and 28.96–80.63 mm (mean 52.14 ± 9.13 mm), respectively. Relative growth analysis showed that total length increased in a higher proportion than carapace region (positive allometry). This region also increased in a higher proportion regarding weight (negative allometry) due to energy cost in reproduction. Of the three criteria used to determine size at the onset of maturity (SOM), the smallest size observed was obtained by physiological SOM I (based on advanced vitellogenesis): 8.22 mm CL, followed by functional SOM II (8.83 mm CL, based on ovigerous females) and physiological SOM III (9.48 mm, based on CL50). SOM was influenced by the population’s phenotype, and SOM I and SOM II showed synchronicity. The estimated maximum fecundity was 2,805 eggs per female, with a mean value of 690 eggs. There was continuous reproduction and the dry season favored the percentage occurrence of ovigerous females (September-December 2016 and July-August 2017). The smaller lengths of the individuals, compared to other female populations, were due to the characteristics of the environment and the intrinsic traits of the studied population. The negative allometry for the length-weight relation and the continuous reproductive period with seasonal variation was similar as that recorded for other Brazilian localities. This suggests that these last characteristics are a pattern for this species, which shows a latitudinal variation only in the sizes reached. The fast maturation and continuous reproduction of M. amazonicum females make them a potential species for commercial exploitation.
Calcified amorphous tumor located on a severely calcified mitral annulus in a patient with normal renal function
Authors: Ushioda Ryohei , Shirasaka Tomonori , Kikuchi Shinsuke , Kamiya Hiroyuki , Kanamori Taro 
Published: December 2021

Abstract
A calcified amorphous tumor (CAT) of the heart is a rare, nonneoplastic, intracavitary cardiac mass. Histological examination shows that it contains calcified and amorphous fibrous material with underlying chronic inflammation. Surgical excision is generally recommended to avoid future embolism. The risk of embolism has been reported to be especially high in mitral-annular-calcification-related CAT, which constitutes a subgroup of CAT that is often associated with end-stage renal disease. A case of a CAT attached to the anterior annulus of the mitral valve that was easily removed with a light touch of the forceps through aortotomy is reported.
Long-term safety and effectiveness of abatacept in Japanese patients with rheumatoid arthritis: 3-year follow-up of a postmarketing surveillance
Authors: Harigai Masayoshi , Tsuritani Katsuki , Yoshizawa Yuri , Atsumi Tatsuya , Tanaka Yoshiya 
Published: December 2021

ABSTRACT

Objectives
To analyse the long-term safety and effectiveness of abatacept for rheumatoid arthritis using real-world, Japanese, postmarketing surveillance data, focusing on serious infections and malignancies as priority events.

Methods
This 3-year, multicentre surveillance registered patients undergoing abatacept treatment by intravenous infusion between July 2011 and October 2012.

Results
The safety and effectiveness analysis sets included 647 and 596 patients, respectively. The total observation period for the safety analysis was 1280 patient-years. Over the 3-year follow-up, the incidence rates of adverse drug reactions (ADRs) and serious ADRs were 19.92 per 100 patient-years (22.87% of patients) and 4.06 per 100 patient-years (6.65% of patients), respectively. Infections and infestations were the most common ADRs (14.68%), followed by respiratory, thoracic, and mediastinal disorders (3.09%). Incidence rates of serious infections as ADRs and malignancy as adverse events were 1.95 and 1.02 per 100 patient-years, respectively. Retention rates at 1 and 3 years were 67.4% and 43.9%, respectively. Significant decreases from baseline were observed in Disease Activity Score (DAS) 28-erythrocyte sedimentation rate and DAS28-C-reactive protein, as well as Health Assessment Questionnaire-Disability Index (HAQ-DI) and modified HAQ scores.

Conclusions
No new safety signals were detected during the 3-year observation period and effectiveness was maintained over time.
Dietary nitrate and nitrite and human health: a narrative review by intake source
Authors: Kotopoulou Sotiria , Zampelas Antonis , Magriplis Emmanuella 
Published: December 2021

Abstract
Nitrate and nitrite are plant nutrients that, although ubiquitous in plant foods, are highly controversial substances in human nutrition because they are also used as additives in processed foods and may be found as contaminants in drinking water. The aim for this narrative review is to provide a thorough insight into the current literature on the relationship between dietary nitrate and nitrite and the health risks and benefits by source of intake. The results highlight beneficial effects of nitrate and nitrite consumption from plant origin on cardiovascular disease and, to date, no positive correlation has been reported with cancer. On the contrary, high intake of these compounds from processed animal-based foods is related to an increased risk of gastro-intestinal cancer. Nitrate in drinking water also raises some concern, because it appears to be related to adverse health effects. The up-to-date debate on the role of nitrate and nitrite in human nutrition seems to be justified and more research is required to verify safe consumption.
Risk Factors for CMV Viremia and Treatment-Associated Adverse Events Among Pediatric Hematopoietic Stem Cell Transplant Recipients
Authors: Heston Sarah M , Young Rebecca R , Tanaka John S , Jenkins Kirsten , Vinesett Richard , Saccoccio Frances M , Martin Paul L , Chao Nelson J , Kelly Matthew S 
Published: December 2021

Abstract

Background
Cytomegalovirus (CMV) causes substantial morbidity and mortality after hematopoietic stem cell transplantation (HSCT). There are limited data on risk factors for CMV viremia and the safety of antiviral medications used to treat CMV in children.

Methods
We conducted a single-center retrospective study of children who underwent HSCT between 2000 and 2016. We used log-logistic regression to evaluate associations between clinical characteristics and CMV-free survival at 100 days after HSCT. We compared the incidences of laboratory-defined adverse events (AEs) during treatment with ganciclovir and foscarnet.

Results
Among 969 children, the median (interquartile range) age was 6.5 (3.1–11.5) years, and 80% underwent allogeneic HSCT. Two hundred forty-four (25%) children developed CMV viremia. Older age (odds ratio [OR], 0.95; 95% CI, 0.92–0.98), male sex (OR, 0.71; 95% CI, 0.51–0.99), non-Black, non-White race (OR, 0.56; 95% CI, 0.36–0.87), umbilical cord blood donor source (OR, 0.28; 95% CI, 0.08–0.97), and CMV seropositivity (R-/D+: OR, 0.17; 95% CI, 0.07–0.41; R+/D-: OR, 0.14; 95% CI, 0.09–0.21; R+/D+: OR, 0.08; 95% CI, 0.04–0.15) were associated with lower odds of 100-day CMV-free survival. Compared with foscarnet, ganciclovir was associated with lower incidences of thrombocytopenia (incidence rate ratio [IRR], 0.38; 95% CI, 0.15–0.97), electrolyte AEs (IRR, 0.42; 95% CI, 0.24–0.75), endocrine AEs (IRR, 0.52; 95% CI, 0.34–0.79), and renal AEs (IRR, 0.36; 95% CI, 0.19–0.65).

Conclusions
CMV viremia occurred commonly among children after HSCT, and ganciclovir and foscarnet were associated with distinct toxicity profiles among children with CMV infection. These findings should be considered when developing CMV prevention and treatment strategies for children after HSCT.