bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coexistence of the native mussel, Mytilus edulis, and the invasive Pacific oyster, Crassostrea (Magallana) gigas, does not affect their growth or mortality, but reduces condition of both species
Authors: Joyce Patrick W. S. , Smyth David M. , Dick Jaimie T. A. , Kregting Louise T. 
Published: March 2021

AbstractEcological impacts caused by invasive alien species can be severe but may vary depending upon environmental conditions. Many European populations of the native mussel, Mytilus edulis, have been invaded by the Pacific oyster, Crassostrea (Magallana) gigas. Although widespread invasions have occurred, interactions between M. edulis and C. gigas have largely been investigated with regards to competition for space and food as well as effects on species assemblages. Experimental investigation of competitive interactions on physiological responses of the two species requires further exploration. To this end, we used a 12-month field manipulation experiment to examine growth rates, mortality and condition indices of the two species occurring in monospecific and heterospecific groups. Growth rates and mortality of both species were similar in monospecific and heterospecific groups, whereas condition indices were significantly reduced for both species in heterospecific groups. Growth rates and condition indices also differed amongst experimental sites, potentially due to differing water motion. Shell weight-length relationships did not explain the observed differences in condition for either species. We show that coexistence between the two species may occur but could be detrimental for both species. We also provide a preliminary viewpoint that water motion can mediate competitive interactions between these species.
An integrated torque-vectoring control framework for electric vehicles featuring multiple handling and energy-efficiency modes selectable by the driver
Authors: Mangia Andrea , Lenzo Basilio , Sabbioni Edoardo 
Published: March 2021

AbstractA key feature achievable by electric vehicles with multiple motors is torque-vectoring. Many control techniques have been developed to harness torque-vectoring in order to improve vehicle safety and energy efficiency. The majority of the existing contributions only deal with specific aspects of torque-vectoring. This paper presents an integrated approach allowing a smooth coordination among the main blocks that constitute a torque-vectoring control framework: (1) a reference generator, that defines target yaw rate and sideslip angle; (2) a high level controller, that works out the required total torque and yaw moment at the vehicle level; (3) a low level controller, that maps the required force and yaw moment into individual wheel torque demands. In this framework, the driver can select one among a number of driving modes that allow to change the vehicle cornering response and, as a second priority, maximise energy efficiency. For the first time, the selectable driving modes include an “Energy efficiency” mode that uses torque-vectoring to prioritise the maximisation of the vehicle energy efficiency, thus further increasing the vehicle driving range. Simulation results show the effectiveness of the proposed framework on an experimentally validated 14 degrees of freedom vehicle model.
Astrocytes as Perspective Targets of Exercise- and Caloric Restriction‐Mimetics
Authors: Lalo Ulyana , Pankratov Yuriy 
Published: March 2021

AbstractEnhanced mental and physical activity can have positive effects on the function of aging brain, both in the experimental animals and human patients, although cellular mechanisms underlying these effects are currently unclear. There is a growing evidence that pre-clinical stage of many neurodegenerative diseases involves changes in interactions between astrocytes and neurons. Conversely, astrocytes are strategically positioned to mediate the positive influence of physical activity and diet on neuronal function. Thus, development of therapeutic agents which could improve the astroglia-neuron communications in ageing brain is of crucial importance. Recent advances in studies of cellular mechanisms of brain longevity suggest that astrocyte-neuron communications have a vital role in the beneficial effects of caloric restriction, physical exercise and their pharmacological mimetics on synaptic homeostasis and cognitive function. In particular, our recent data indicate that noradrenaline uptake inhibitor atomoxetine can enhance astrocytic Ca2+-signaling and astroglia-driven modulation of synaptic plasticity. Similar effects were exhibited by caloric restriction-mimetics metformin and resveratrol. The emerged data also suggest that astrocytes could be involved in the modulatory action of caloric restriction and its mimetics on neuronal autophagy. Still, the efficiency of astrocyte-targeting compounds in preventing age-related cognitive decline is yet to be fully explored, in particular in the animal models of neurodegenerative diseases and autophagy impairment.
Agreement between rhinomanometry and computed tomography-based computational fluid dynamics
Authors: Berger Manuel , Giotakis Aris I. , Pillei Martin , Mehrle Andreas , Kraxner Michael , Kral Florian , Recheis Wolfgang , Riechelmann Herbert , Freysinger Wolfgang 
Published: March 2021

Abstract
Purpose
Active anterior rhinomanometry (AAR) and computed tomography (CT) are standardized methods for the evaluation of nasal obstruction. Recent attempts to correlate AAR with CT-based computational fluid dynamics (CFD) have been controversial. We aimed to investigate this correlation and agreement based on an in-house developed procedure.

Methods
In a pilot study, we retrospectively examined five subjects scheduled for septoplasty, along with preoperative digital volume tomography and AAR. The simulation was performed with Sailfish CFD, a lattice Boltzmann code. We examined the correlation and agreement of pressure derived from AAR (RhinoPress) and simulation (SimPress) and these of resistance during inspiration by 150 Pa pressure drop derived from AAR (RhinoRes150) and simulation (SimRes150). For investigation of correlation between pressures and between resistances, a univariate analysis of variance and a Pearson’s correlation were performed, respectively. For investigation of agreement, the Bland–Altman method was used.

Results
The correlation coefficient between RhinoPress and SimPress was r = 0.93 (p < 0.001). RhinoPress was similar to SimPress in the less obstructed nasal side and two times greater than SimPress in the more obstructed nasal side. A moderate correlation was found between RhinoRes150 and SimRes150 (r = 0.65; p = 0.041).

Conclusion
The simulation of rhinomanometry pressure by CT-based CFD seems more feasible with the lattice Boltzmann code in the less obstructed nasal side. In the more obstructed nasal side, error rates of up to 100% were encountered. Our results imply that the pressure and resistance derived from CT-based CFD and AAR were similar, yet not same.
Empirical and theoretical perspectives in sales and operations planning
Authors: Kreuter Tobias , Scavarda Luiz Felipe , Thomé Antonio Márcio Tavares , Hellingrath Bernd , Seeling Marcelo Xavier 
Published: March 2021

AbstractThis paper’s purpose is to evaluate empirical and theoretical perspectives in Sales and Operations Planning (S&OP). The methodology consists of a systematic literature review, analysing 292 publications from academics and practitioners. The results reveal that the empirical evidence has been initially obtained by practitioners and subsequently acquired by academics with a growing interest in recent years. Three main research streams are identified: S&OP and performance, implementation of S&OP, and contextualisation of S&OP designs. The investigation of theoretical foundations reveals an upward trend in external general theory usage and first signs of internal theory development in S&OP. The research findings call for more exploratory research to enhance the knowledge in the identified research streams and their interrelation. Herein, applying the design science approach is recommended to integrate practitioners into academic research. Further implications embrace a call for more theory-informed empirical S&OP research in a two-prone agenda: applying general theories from other fields and developing internal theories through middle-range theorising. A limitation of this paper is its focus on empirical studies, not embracing conceptual papers. Applications of this paper’s findings can help academics and practitioners to advance their understanding of the S&OP phenomenon. The awareness of study findings in the three main research streams, combined with empirical and theoretical research implications, can support the development of solutions to improve the S&OP effectiveness and evidence-based decisions in real-life settings. This work’s originality lies in the analysis of the S&OP literature with the focus on the evolution of empirical evidence and the theoretical foundations.
A solution for factorial validity testing of three-item scales: An example of tau-equivalent strict measurement invariance of three-item loneliness scale
Authors: Czerwiński Stanisław K. , Atroszko Paweł Andrzej 
Published: March 2021

AbstractUltra-short scales are increasingly popular in surveys. Congeneric model fit of a three-item scale cannot be tested with Confirmatory Factor Analysis (CFA) without additional assumptions because the number of degrees of freedom is equal to zero. A more rigorous tau-equivalent model, assuming equality of factor loadings can be tested instead. The objective of this study was to demonstrate this approach with an example of the psychometric study of the Polish version of the Three-Item Loneliness Scale (TILS), and to discuss the arising problems and possible solutions. There seems to be a high need for such analysis because currently, some properties of CFA make it an approach still predominant over Item Response Theory (IRT) models in the quality of life research. A sample of 3510 students completed TILS together with the questionnaires measuring a variety of indicators of well-being. The results provided evidence for a good fit of a tau-equivalent model. Furthermore, multi-group CFAs provided support for strict measurement invariance of this model. To the Authors’ knowledge, it is the first practical application of a tau-equivalent model to testing the factorial validity of an ultra-short scale and probably the first empirical case of tau-equivalent measurement invariance in psychological literature in general. TILS showed good criterion validity and satisfactory reliability. Unidimensionality of three-item scales can be examined with a tau-equivalent model that has some favorable psychometric properties. However, it might be exceedingly restrictive in certain practical cases. When developing a new short scale, it is recommended to maintain at least four items.
Non-native speaker perception of Intelligent Virtual Agents in two languages: the impact of amount and type of grammatical mistakes
Authors: Obremski David , Lugrin Jean-Luc , Schaper Philipp , Lugrin Birgit 
Published: March 2021

AbstractHaving a mixed-cultural membership becomes increasingly common in our modern society. It is thus beneficial in several ways to create Intelligent Virtual Agents (IVAs) that reflect a mixed-cultural background as well, e.g., for educational settings. For research with such IVAs, it is essential that they are classified as non-native by members of a target culture. In this paper, we focus on variations of IVAs’ speech to create the impression of non-native speakers that are identified as such by speakers of two different mother tongues. In particular, we investigate grammatical mistakes and identify thresholds beyond which the agents is clearly categorised as a non-native speaker. Therefore, we conducted two experiments: one for native speakers of German, and one for native speakers of English. Results of the German study indicate that beyond 10% of word order mistakes and 25% of infinitive mistakes German-speaking IVAs are perceived as non-native speakers. Results of the English study indicate that beyond 50% of omission mistakes and 50% of infinitive mistakes English-speaking IVAs are perceived as non-native speakers. We believe these thresholds constitute helpful guidelines for computational approaches of non-native speaker generation, simplifying research with IVAs in mixed-cultural settings.
Assessing the costs and environmental benefits of IMO regulations of ship-originated SOx and NOx emissions in the Baltic Sea
Authors: Repka Sari , Erkkilä-Välimäki Anne , Jonson Jan Eiof , Posch Maximilian , Törrönen Janne , Jalkanen Jukka Pekka 
Published: March 2021

AbstractTo assess the value of the environmental benefits of the Sulphur Emission regulation (SECA) that came into force in 2015, changes in depositions of SOx and NOx from ship exhaust gas emissions were modelled and monetized for the Baltic Sea region for the years 2014 and 2016. During this period, the total deposition of SOx in the study area decreased by 7.3%. The decrease in ship-originated SOx deposition from 38 kt to 3.4 kt (by over 88%) was translated into a monetary value for the ecosystem impacts of nearly 130 million USD, according to the EcoValue08 model. This is less than the modelled health benefits, but it is not insignificant. For NOx, there was no decreasing trend. The exceedance of the critical loads of SOx and NOx was also estimated. The effect of Baltic shipping on the exceedance of critical loads of acidification after SECA is very small, but Baltic shipping still has a considerable effect on the exceedance of critical loads for eutrophication.
Mapping Viscoelastic Properties Using Helical Magnetic Nanopropellers
Authors: Ghosh Arijit , Ghosh Ambarish 
Published: March 2021

AbstractArtificial micro/nanomachines have been envisioned and demonstrated as potential candidates for targeted drug or gene delivery, cell manipulation, environmental and biological sensing and in lab on chip applications. Here, we have used helical nanomachines to measure the local rheological properties of a viscoelastic media. The position of the helical nanomachine/nanopropeller was controlled precisely using magnetic fields with simultaneous measurements of the mechanical properties of a complex and heterogeneous fluidic environment. We demonstrated that the motion of the helical nanopropeller is extremely sensitive to fluid elasticity and the speed of propulsion of the nanopropeller can be used as a measure of the local elastic relaxation time. Taken together, we report a promising new technique of mapping the rheological properties by helical nanopropellers with very high spatial and temporal resolutions, with performance superior to existing techniques of passive or active microrheology.
MACMIC Reveals a Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes
Authors: Wang Guangyu , Xia Bo , Zhou Man , Lv Jie , Zhao Dongyu , Li Yanqiang , Bu Yiwen , Wang Xin , Cooke John P. , Cao Qi , Lee Min Gyu , Zhang Lili , Chen Kaifu 
Published: March 2021

Abstract
Numerous studies of relationship between epigenomic features have focused on their strong correlation across the genome, likely because such relationship can be easily identified by many established methods for correlation analysis. However, two features with little correlation may still colocalize at many genomic sites to implement important functions. There is no bioinformatic tool for researchers to specifically identify such feature pairs. Here, we develop a method to identify feature pairs in which two features have maximal colocalization minimal correlation (MACMIC) across the genome. By MACMIC analysis of 3306 feature pairs in 16 human cell types, we reveal a dual role of CCCTC-binding factor (CTCF) in epigenetic regulation of cell identity genes. Although super-enhancers are associated with activation of target genes, only a subset of super-enhancers colocalized with CTCF regulate cell identity genes. At super-enhancers colocalized with CTCF, CTCF is required for the active marker H3K27ac in cell types requiring the activation, and also required for the repressive marker H3K27me3 in other cell types requiring repression. Our work demonstrates the biological utility of the MACMIC analysis and reveals a key role for CTCF in epigenetic regulation of cell identity. The code for MACMIC is available at https://github.com/bxia888/MACMIC.
Gigantic Genomes Provide Empirical Tests of Transposable Element Dynamics Models
Authors: Wang Jie , Itgen Michael W. , Wang Huiju , Gong Yuzhou , Jiang Jianping , Li Jiatang , Sun Cheng , Sessions Stanley K. , Mueller Rachel Lockridge 
Published: March 2021

Abstract
Transposable elements (TEs) are a major determinant of eukaryotic genome size. The collective properties of a genomic TE community reveal the history of TE/host evolutionary dynamics and impact present-day host structure and function, from genome to organism levels. In rare cases, TE community/genome size has greatly expanded in animals, associated with increased cell size and changes to anatomy and physiology. Here, we characterize the TE landscape of the genome and transcriptome in an amphibian with a giant genome — the caecilianIchthyophis bannanicus, which we show has a genome size of 12.2 Gb. Amphibians are an important model system because the clade includes independent cases of genomic gigantism. The I. bannanicus genome differs compositionally from other giant amphibian genomes, but shares a low rate of ectopic recombination-mediated deletion. We examine TE activity using expression and divergence plots; TEs account for 15% of somatic transcription, and most superfamilies appear active. We quantify TE diversity in the caecilian, as well as other vertebrates with a range of genome sizes, using diversity indices commonly applied in community ecology. We synthesize previous models that integrate TE abundance, diversity, and activity, and test whether the caecilian meets model predictions for genomes with high TE abundance. We propose thorough, consistent characterization of TEs to strengthen future comparative analyses. Such analyses will ultimately be required to reveal whether the divergent TE assemblages found across convergent gigantic genomes reflect fundamental shared features of TE/host genome evolutionary dynamics.
Pediatric high risk neuroblastoma with autologous stem cell transplant – 20 years of experience
Authors: Khan Saadiya , AlSayyad Khulood , Siddiqui Khawar , AlAnazi Awatif , AlSeraihy Amal , AlAhmari Ali , ElSolh Hassan , Ghemlas Ibrahim , AlSaedi Hawazen , AlJefri Abdullah , Ali Afshan , AlFawaz Ibrahim , AlKofide Amani , Ayas Mouhab 
Published: March 2021

Background and Objective:
Neuroblastoma is the most common extracranial solid tumor found in pediatric patients. High-risk neuroblastoma (HR-NBL) can be characterized by metastasis, age, and other tumor characteristics that result in an adverse outlook for this patient cohort. The standard of care includes induction chemotherapy, surgery, followed by stem cell autologous transplant (ASCT), and later, antidisialoganglioside (anti-GD2) antibodies. In this study, we provide the survival and toxicity data of our HR-NBL patients treated with a single ASCT.

Methods:
We retrospectively analyzed pediatric HR-NBL patients treated with single ASCT after a carboplatin, etoposide, and melphalan (CEM) regimen in our institution between January 1993 and December 2014.

Results:
There were 99 evaluable patients with male predominance. The median age at diagnosis was 3 years. Most of our HR-NBL patients were stage 4 (88%). All patients received ASCT. Peripheral blood was the graft source in 58% of the patients. Time for hematological count recovery with bone marrow as a graft source was prolonged but not statistically significant when compared with PBSCs. Of all the patients, 58% received radiation therapy to residual disease. Overt secondary leukemia was not seen in any of these patients. Three-year overall survival (OS) was 68.5% ± 5.2% and the 3-year event-free survival (EFS) was (48.3% ± 5.2%).

Conclusion:
Our HR-NBL patients tolerated high-dose chemotherapy well followed by single autologous stem cell transplant. Tandem transplant is a feasible option in our patient cohort. Apart from secondary solid tumors, there were no long-term complications seen.
Cost-Effectiveness Analysis: Lymph Node Transfer vs Lymphovenous Bypass for Breast Cancer-Related Lymphedema
Authors: Sekigami Yurie , Char Sydney , Mullen Cate , Huber Kathryn , Cao Yu , Buchsbaum Rachel , Graham Roger , Nardello Salvatore , Singhal Dhruv , Chatterjee Abhishek 
Published: March 2021

BACKGROUND:
Lymph node transfer (LNT) and lymphovenous bypass (LVB) have been described as 2 major surgical options for patients with breast cancer-related lymphedema (BCRL) who have failed conservative therapy. The objective of our study was to perform a cost-effectiveness analysis comparing LNT and LVB for the treatment of BCRL.

STUDY DESIGN:
Rates of infection, lymph leak, and failure of LNT and LVB were obtained from a previously published meta-analysis. Failure of surgery was defined as the inability to cease compression therapy postoperatively. Procedural costs were calculated from Medicare reimbursement rates. Cost of conservative management of postoperative surgical site infection, lymph leak, and continued decongestive physiotherapy after failed surgery were obtained from literature review. Average utility scores for each health state were calculated using a visual analog scale survey, then converted to quality-adjusted life years (QALYs). A decision tree was constructed, and incremental cost-effectiveness ratio was assessed at $50,000/QALY. Deterministic and probabilistic sensitivity analyses were performed to evaluate the robustness of our findings.

RESULTS:
LNT was less costly ($22,492 vs $31,927) and more effective (31.82 QALY vs 29.24 QALY) than LVB. One-way (deterministic) sensitivity analysis demonstrated that LNT became cost-ineffective when its failure rate was more than 43.8%. LVB became more cost-effective than LNT when its failure rate was less than 21.4%. Probabilistic sensitivity analysis using Monte-Carlo simulation indicated that even with uncertainty present in the variables analyzed, the majority of simulations (97%) favored LNT as the more cost-effective strategy.
Conclusions: LNT is a dominant, cost-effective strategy compared to LVB for the treatment of BCRL.