bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-Vivo Studies of the Angiogenic Potential of Mandur Bhasma
Authors: Tomar Ekta , Wairagade Sonali , Gharote Arachana , Ambad Ranjit S. , Chandi Dhruba Hari 
Published: August 2021

Background: Mandur Bhasma is a herbo-mineral compound. It is prepared by Putapaka method. It is described as Raktasanjanan. In the current study, Mandur Bhasma was prepared with a standardized method w.s.r to Rasatarangini and an experimental study was done to observe the Angiogenic property of Mandur Bhasma. The current study will analyze angiogenic potential of Mandur Bhasma using chick CAM model. This research is intended to study the possible role of Mandur Bhasma on angiogenesis and establishing properties of Mandur Bhasma as an angiogenic by newer means. The experimental study inside the egg shell will be carried out on a membrane known as “chorioallantoic membrane”.
Objectives:

To Prepare Mandur Bhasma
Physicochemical and Analytical study of Mandur Bhasma
To verify the angiogenic potential of Mandur bhasma using the chicken chorioallantoic membrane (CAM) model.
To compare Angeogenic potential of Mandur bhasma with standard drug progesterone

Methodology: Relevant classical literature regarding Mandur will be reviewed and the data will be collected. Mandur Shodhan with Gomutra and Mandur Maran with Triphala decoction will be done.
Analytical Study like Organoleptic Test for Rasa, Gandha, Varna, Sparsha, Physicochemical Tests and other analytical test like ICP-AES /ICPMS, XRD structure of Bhasma, EDAX-NANO Particle Size will be done.
Expected Results: Changes will be observed in objective outcomes.
Conclusion: Conclusion will be drawn by suitably analyzing data.
Hypertensive Patient Compliance with Pharmacist Intervention: A Systematic Review
Authors: Alshahrani Abdullah M. , Al-Nasser Marzoq S. , Alhawashi Saif T. , Alqahtani Saad , Alqahtani Ali A. , Alqahtani Saad S. 
Published: August 2021

Background: Pharmacists and physicians can work together to improve patient compliance especially for the management of hypertension. Medication adherence leads to advance health and reduces hospitalizations (morbidity), death (mortality) and healthcare costs.
Objectives: Involvement of pharmacist in treatment intervention can result in improved understanding about hypertension and it can increase medication adherence to antihypertensive therapy which ultimately advance overall quality of life.
Study design and methods: A comprehensive research study was conducted using two eminent databases i.e. PUBMED and EMBASE. The research articles from 1996 to 2015 were analyzed. All the selected articles were about pharmacist intervention, hypertensive patient compliance and hypertension medication adherence.
Results: Some studies show no control in BP; however, there was significant difference in the systolic and diastolic BP pre and post pharmacist intervention (Systolic from 158.1±14.4 to 143.8 ± 10.7, Diastolic from 100.6 ±11.5 to 89.8 ± 9.7). Conversely, in some studies BP was controlled in about 29.9% of control group and in 63% of the intervention group.
Conclusion: Results showed many methods can improve medication adherence and blood pressure including counseling patients in person, collaboration between pharmacists and physicians, and using technology like telecommunication to intensify patients counseling. Pharmacist intervention can significantly increase disease-related knowledge, blood pressure control and medication adherence in patients with hypertension.
Climate Change Impact in Flores Island, a Dry Region in Indonesia
Authors: Kusumastuti Cilcia , Gode Dicky , Kurnianto Yobella Febe , Syaranamual Frederik Jones 
Published: August 2021

Climate change impacts have gained great attention to be studied in various fields. In this paper, an investigation of rainfall pattern change is performed using three statistical methods, i.e., simple linear regression, t-test, and Mann-Kendall’s test. The analysis is performed at 10- and 20-year time scales of daily, monthly, and annual rainfall in Flores Island, a dry region in Indonesia. In general, an increasing monthly rainfall trend is detected in the rainy season (October – April) at a 20-year period, using all three methods. Specifically, a significant increasing trend in March 1989 – 2008 is observed, and it contributes to the significant increasing trend of annual rainfall. The findings presented in this paper should be an alert for potential climate change impacts in the region. The positive consideration of having more rainfall in a dry region might turn into a negative reality when adaptation measures are not well-prepared.
XPS and ToF‐SIMS Characterization of New Biodegradable Poly(Peptide‐Urethane‐Urea) Block Copolymers
Authors: Zorn Gilad , Simonovsky Felix I. , Ratner Buddy D. , Castner David G. 
Published: August 2021

AbstractNew, linear, segmented poly(peptide‐urethane‐urea) (PPUU) block copolymers are synthesized and their surface compositions are characterized with angle dependent X‐ray photoelectron spectroscopy (ADXPS) and time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). These new PPUU block copolymers contain three types of segments. The soft segment (SS) is poly(caprolactone diol) (PCL). The hard segment is lysine diisocyanate with a hydrazine chain extender. The oligopeptide segment (OPS) contains three types of amino acids (proline, hydroxyproline, and glycine). Incorporation of the OPS into the polyurethane backbone is done to provide a synthetic polymer material with controllable biodegradation properties. As biodegradation processes normally are initiated at the interface between the biomaterial and the living tissue, it is important to characterize the surface composition of biomaterials. ADXPS and ToF‐SIMS results show that the surfaces of all four polymers are enriched with the PCL SS, the most hydrophobic component of the three polymer segments.
Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy
Authors: Li Zhaoting , Wang Yixin , Liu Jun , Rawding Piper , Bu Jiyoon , Hong Seungpyo , Hu Quanyin 
Published: August 2021

AbstractBacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria‐based delivery systems have drawn wide interest in the diagnosis and treatment of various diseases, including cancer, infectious diseases, kidney failure, and hyperammonemia. Notably, at the interface of chemical biotechnology and bacteria, many research opportunities have been initiated, opening a promising frontier in biomedical application. Herein, the current synergy of chemical biotechnology and bacteria, the design principles for bacteria‐based delivery systems, the microbial modulation, and the clinical translation are reviewed, with a special focus on the emerging advances in diagnosis and therapy.
The Magneto‐Transport Properties of Cr1/3TaS2 with Chiral Magnetic Solitons
Authors: Obeysekera Dimuthu , Gamage Kasun , Gao Yunpeng , Cheong Sang‐wook , Yang Junjie 
Published: August 2021

AbstractCr1/3TaS2—a candidate of chiral magnet—has been reported as a trivial ferromagnetic material. In contrast, the Cr1/3TaS2 single crystals exhibit a chiral helimagnetic (CHM) transition near 140 K. The magnetic moment versus magnetic field curves reveal a CHM—chiral soliton lattice (CSL)—forced ferromagnetic (FFM) transition in the magnetic ordered state. The conducting electrons interact with the CHM and CSL orders, giving rise to the nontrivial magnetoresistance (MR) in the Cr1/3TaS2 single crystals. The normalized magnetic moment and normalized MR fit well with the analytical functions for chiral soliton density. The magnetic phase diagrams constructed from the magnetic moment data and MR data suggest a possible tri‐critical point. Compared with the isostructural Cr1/3NbS2, the CHM transition temperature of Cr1/3TaS2 is 13 K higher, the CSL—FFM transition field is about 10 times larger, and the Dzyaloshinskii‐Moriya interaction strength is 3 times bigger. The latter two likely originate from the strong spin‐orbit coupling (SOC) of Cr1/3TaS2. The work clarifies that high‐quality Cr1/3TaS2 single crystals are chiral magnets and Cr1/3(Nb,Ta)S2 could serve as an intriguing platform for the flexible engineering of chiral magnetic solitons with tunable SOC.
Do crops' responses to sulfur vary with its forms?
Authors: Goyal Diksha , Franzen David W. , Chatterjee Amitava 
Published: August 2021

AbstractThe most common formsof S fertilizers in the northern Great Plains are ammonium sulfate (AS), ammonium thiosulfate (ATS), and elemental S (ES). Among these, AS is preferred over the others because of its readily available SO42– form, and it can be blended with other dry fertilizer granules, but SO42– is prone to leaching. Recently, fertilizer industries introduced micronized (<100 μm) S (MS) fertilizer formulations to hope that the smaller elemental S particles would increase the rate of S oxidation. Across the Red River Valley of North Dakota and Minnesota, field trials were conducted to compare the response of corn (Zea mays L.), spring wheat (Triticum aestivum L.), and sugar beet (Beta vulgaris L.) to the application of different forms of S (AS, ATS, mono ammonium phosphate or MAP‐10S [5% ES + 5% AS], MAP + MS, AS + MS, muriate of potash [MOP] + MS, urea ammonium nitrate [UAN] + MS). Spring wheat only had a significant positive response to S forms, with ATS having the highest grain yield in 2019, significantly higher than AS and AS + MS. In 2020, UAN + MS had the highest grain yield, only higher than the control. Corn and sugar beet did not respond to addition of or to S forms. Corn, sugar beet, and spring wheat yields were indifferent to supply and forms of S in the Red River Valley.
COVID‐19 mortality among Amalgamated Transit Union (ATU) and Transport Workers Union (TWU) workers—March–July 2020, New York City metro area
Authors: Tomasi Suzanne E. , Ramirez‐Cardenas Alejandra , Thiese Matthew S. , Rinsky Jessica L. , Chiu Sophia K. , Luckhaupt Sara , Bateman Russell , Burrer Sherry L. 
Published: August 2021

AbstractBackgroundTransit workers have jobs requiring close public contact for extended periods of time, placing them at increased risk for severe acute respiratory syndrome coronavirus 2 infection and more likely to have risk factors for coronavirus disease 2019 (COVID‐19)‐related complications. Collecting timely occupational data can help inform public health guidance for transit workers; however, it is difficult to collect during a public health emergency. We used nontraditional epidemiological surveillance methods to report demographics and job characteristics of transit workers reported to have died from COVID‐19.MethodsWe abstracted demographic and job characteristics from media scans on COVID‐19 related deaths and reviewed COVID‐19 memorial pages for the Amalgamated Transit Union (ATU) and Transport Workers Union (TWU). ATU and TWU provided a list of union members who died from COVID‐19 between March 1–July 7, 2020 and a total count of NYC metro area union members. Peer‐reviewed publications identified through a scientific literature search were used to compile comparison demographic statistics of NYC metro area transit workers. We analyzed and reported characteristics of ATU and TWU NYC metro area decedents.ResultsWe identified 118 ATU and TWU NYC metro area transit worker COVID‐19 decedents with an incidence proportion of 0.3%. Most decedents were male (83%); median age was 58 years (range: 39–71). Median professional tenure was 20 years (range: 2–41 years). Operator (46%) was the most reported job classification. More than half of the decedents (57%) worked in positions associated with close public contact.ConclusionData gathered through nontraditional epidemiological surveillance methods provided insight into risk factors among this workforce, demonstrating the need for mitigation plans for this workforce and informing transit worker COVID‐19 guidance as the pandemic progressed.
Self‐Assembled Metal–Organic Framework Stabilized Organic Cocrystals for Biological Phototherapy
Authors: Zeng Le , Huang Ling , Wang Zhonghe , Wei Jianwei , Huang Kai , Lin Wenhai , Duan Chunying , Han Gang 
Published: August 2021

AbstractOrganic self‐assembled co‐crystals have garnered considerable attention due to their facile synthesis and intriguing properties, but supramolecular interactions restrict their stability in aqueous solution, which is especially important for biological applications. Herein, we report on the first biological application of aqueous dispersible self‐assembled organic co‐crystals via the construction of metal–organic framework (MOF) ‐stabilized co‐crystals. In particular, we built an electron‐deficient MOF with naphthalene diimide (NDI) as the ligand and biocompatible Ca2+ as the metal nodes. An electron donor molecule, pyrene, was encapsulated to form the host–guest MOF self‐assembled co‐crystal. We observed that such MOF structure leads to uniquely high‐density ordered arrangement and the close intermolecular distance (3.47 Å) of the charge transfer pairs. Hence, the concomitant superior charge transfer interaction between pyrene/NDI can be attained and the resultant photothermal conversion efficiency of Py@Ca‐NDI in aqueous solution can thus reach up to 41.8 %, which, to the best of our knowledge, is the highest value among the reported organic co‐crystal materials; it is also much higher than that of the FDA approved photothermal agent ICG as well as most of the reported MOFs. Based on this realization, as a proof of concept, we demonstrated that such a self‐assembled organic co‐crystal platform can be used in biological applications that are exemplified via highly effective long wavelength light photothermal therapy.
Carbon Nitride Supported High‐Loading Fe Single‐Atom Catalyst for Activation of Peroxymonosulfate to Generate 1O2 with 100 % Selectivity
Authors: Zhang Long‐Shuai , Jiang Xun‐Heng , Zhong Zi‐Ai , Tian Lei , Sun Qing , Cui Yi‐Tao , Lu Xin , Zou Jian‐Ping , Luo Sheng‐Lian 
Published: August 2021

AbstractSinglet oxygen (1O2) is an excellent active species for the selective degradation of organic pollutions. However, it is difficult to achieve high efficiency and selectivity for the generation of 1O2. In this work, we develop a graphitic carbon nitride supported Fe single‐atoms catalyst (Fe1/CN) containing highly uniform Fe‐N4 active sites with a high Fe loading of 11.2 wt %. The Fe1/CN achieves generation of 100 % 1O2 by activating peroxymonosulfate (PMS), which shows an ultrahigh p‐chlorophenol degradation efficiency. Density functional theory calculations results demonstrate that in contrast to Co and Ni single‐atom sites, the Fe‐N4 sites in Fe1/CN adsorb the terminal O of PMS, which can facilitate the oxidization of PMS to form SO5.−, and thereafter efficiently generate 1O2 with 100 % selectivity. In addition, the Fe1/CN exhibits strong resistance to inorganic ions, natural organic matter, and pH value during the degradation of organic pollutants in the presence of PMS. This work develops a novel catalyst for the 100 % selective production of 1O2 for highly selective and efficient degradation of pollutants.
Dynamic Constitutional Frameworks as Antibacterial and Antibiofilm Agents
Authors: Diaconu Andrei , Coenye Tom , Barboiu Mihail , Vincent Stéphane P. 
Published: August 2021

AbstractDynamic constitutional frameworks (DCFs) were synthesized and screened for biofilm inhibition or disruption. They are composed of a trialdehyde core reversibly linked to a diamine PEG connector and to a variety of neutral, anionic, or cationic heads, to generate a library of DCFs to generate multivalent dendritic architectures in the presence of Pseudomonas aeruginosa and Staphylococcus aureus. The best DCFs were always polycationic and the nature of the cationic heads significantly impact the antibiofilm activity. The best antibiofilm activity was observed for DCF3B, displaying a polyethyleneimine head. A simple inactive guanidinium functional head strongly inhibited biofilm growth when assayed as a multivalent DCF3C. Using a more advanced in vitro biofilm model of chronic wound infection, DCF3C was found significantly superior than all other DCFs. These results demonstrate the versatility and effectiveness of DCFs as low cost and efficient systems for antibiofilm disruption.
Long‐term stability of blends of sesame oil or soybean oil with tuna oil under daily use conditions
Authors: Zhao Peng , Zhang Xin , Jin Yan , Xu Luyan 
Published: August 2021

AbstractThe commercial feasibility of blending tuna oil into edible oil was studied from the perspective of stability under daily use conditions. A 210‐day long‐term simulation experiment was carried out on tuna oil blended with soybean or sesame oil at room temperature and cold storage (4°C). The bottle caps of all samples were opened manually and left open for 5 min every day to simulate the daily use of edible oil by consumers. The results indicate that cold storage can stabilize the blended oils containing tuna oil, and the peroxide and anisidine values of blended oil can be controlled at the recommended levels for at least 90 days by adding sesame oil. The polyunsaturated fatty acid content of all samples decreased by no more than 10% during the study term. The results of the sensory test indicated that in the daily use situation, the mixture of 20% tuna oil with 80% sesame oil could be stored at 4°C for up to 60 days without unacceptable quality and flavor changes. This study presents suggestions on how to design the packaging volume of the blended oil containing tuna oil, how to store the blended oil, and the term of best used before (once open) in practical commercial applications.
Screening and identification of potential novel lipid biomarkers for non‐small cell lung cancer using ultra‐high performance liquid chromatography tandem mass spectrometry
Authors: Han Yu‐Shuai , Shi Li‐Ying , Chen Jia‐Xi , Chen Jing , Li Zhi‐Bin , Lu Qi‐Qi , Zhang Shan‐Qiang , Liu Jun , Yi Wen‐Jing , Jiang Ting‐Ting , Li Ji‐Cheng , Huang Jian 
Published: August 2021

AbstractLung cancer is characterized by a high incidence rate and low survival rate. It is important to achieve early diagnosis of the disease. We applied ultra‐high performance liquid chromatography tandem mass spectrometry to screen plasma lipid spectrum in non‐small cell lung cancer (NSCLC) patients, healthy controls (HC), and community‐acquired pneumonia (CAP) patients. Modeling employing orthogonal partial least squares‐discriminant analysis combined with t‐test was used to screen the differential lipids. Logistic regression analysis was used to establish the diagnostic model, while the accuracy was verified by 10‐fold cross‐validation. The results showed that the abnormal metabolism of lipid in NSCLC mainly comprised fatty acid metabolism, phospholipid metabolism, and glyceride metabolism. Four potential biomarkers, including LPC (14:0/0:0), LPI (14:1/0:0), DG (14:0/18:2/0:0), and LPC (16:1/0:0), were fitted by the receiver operating characteristic curve model with the area under curve (AUC) value of 0.856, and the specificity and sensitivity were 87.0 and 78.0%, respectively. The results of cross validation showed that the AUC value of the model was 0.812, the sensitivity was 72.9%, and the specificity was 82.6%. The positive rate of four potential lipid biomarkers in this study (>60.0%) was higher than that of existing tumor biomarkers in the clinical application. We investigated the plasma lipid profile of NSCLC patients and identified lipid biomarkers with potential diagnostic values. From the lipidomics perspective, our study may lay a foundation for the biomarker‐based early diagnosis of lung cancer.
Polyhydroxybenzoic acid derivatives as potential new antimalarial agents
Authors: Degotte Gilles , Pirotte Bernard , Frédérich Michel , Francotte Pierre 
Published: August 2021

AbstractWith more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure–activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC50 ~20 µM, SI > 5) often associated with interesting water solubility. Moreover, this has confirmed the critical importance of free phenolic functions (pyrogallol moiety) for the antimalarial effect. Methyl 4‐benzoxy‐3,5‐dihydroxybenzoate (39) has, for the first time, been recognized as a potential lead for future research because of its marked inhibitory activity against Plasmodium falciparum and its significant hydrosolubility (3.72 mM).
Validierung verteilter faseroptischer Sensorik zur Dehnungsmessung im Betonbau
Authors: Weisbrich Martin , Holschemacher Klaus , Bier Thomas 
Published: August 2021

AbstractDie Bedeutung von faseroptischen Sensoren hat infolge der verstärkten Strukturüberwachung (Structural Health Monitoring, SHM) von Bauwerken und Bauteilen immens zugenommen [1]. Die verteilte faseroptische Dehnungsmessung auf Basis der Rayleigh‐Streuung ist dabei ein besonders vielversprechendes Verfahren, welches eine hohe Ortsauflösung und Messempfindlichkeit an jedem Punkt der Messfaser bietet, sodass geringste Dehnungsänderungen erfasst werden können [2]. Allerdings fehlen aktuell Qualitätsstandards, die einen zuverlässigen Einsatz in der Dehnungsmessung gewährleisten. Zur Etablierung solcher Standards sind am Institut für Betonbau an der HTWK Leipzig im Zuge einer Dissertation unterschiedliche Fasercoating‐Klebstoff‐Konfigurationen für verschiedene Szenarien im Betonbau validiert worden [3]. Die Ergebnisse sind vielversprechend: Im Vergleich zu den Referenzmessverfahren zeigten die faseroptischen Sensoren Dehnungsverluste durch Coating und/oder Klebstoff von unter 5 % und damit weitaus geringere Werte als entsprechend dem bisherigen Kenntnisstand zu erwarten war.