bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship among total tear IgE, specific serum IgE, and total serum IgE levels in patients with pollen-induced allergic conjunctivitis
Authors: Yamana Yasuo , Yamana Satoshi , Uchio Eiichi 
Published: August 2021

Abstract
Background
Recently, the number of patients with pollinosis, particularly Japanese cedar pollinosis, has markedly increased. We previously reported about local allergic conjunctivitis, which is a phenotype of allergic conjunctivitis (AC). AC cases are often sensitized by various antigens. This study aimed to investigate the relationship among total tear IgE (t-tIgE), specific serum IgE (s-sIgE), and total serum IgE (t-sIgE) levels in patients with pollen-induced AC.

Methods
In 2019, 1372 patients were clinically diagnosed with AC at the Yamana Eye Clinic using t-tIgE, t-sIgE, and s-sIgE tests against 39 allergens. Among the pollen-induced AC patients who underwent allergen testing, 99 tested positives for s-sIgE against pollen. The subjects comprised 33 (33.3%) male and 66 (66.7%) female individuals aged 9–86 years.

Results
The t-tIgE test was positive in 68 (68.7%) patients and negative in 31 (31.3%) patients. In the t-sIgE test, 45 (45.5%) patients had t-sIgE levels above the reference value of 170 IU/mL. The higher the total score of the positive class value of each pollen-specific IgE (pollen-sIgE) antibody, the higher the positive rate of t-tIgE (p < 0.001). Of 32 patients in whom food-specific IgE (food-sIgE) was detected, 81.3% of the pollen-sIgE-positive and food-sIgE-positive cases were also positive for t-sIgE and t-tIgE. However, significant difference was not found between the total score of food-sIgE of the t-tIgE positive group and negative group.

Conclusions
Pollen-induced AC is caused by pollen sensitization of the conjunctiva. Food-induced AC might be induced by the different pathological mechanism involved in pollen-induced AC.
Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern
Authors: Osterman Andreas , Iglhaut Maximilian , Lehner Andreas , Späth Patricia , Stern Marcel , Autenrieth Hanna , Muenchhoff Maximilian , Graf Alexander , Krebs Stefan , Blum Helmut , Baiker Armin , Grzimek-Koschewa Natascha , Protzer Ulrike , Kaderali Lars , Baldauf Hanna-Mari , Keppler Oliver T. 
Published: August 2021

AbstractA versatile portfolio of diagnostic tests is essential for the containment of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. Besides nucleic acid-based test systems and point-of-care (POCT) antigen (Ag) tests, quantitative, laboratory-based nucleocapsid Ag tests for SARS-CoV-2 have recently been launched. Here, we evaluated four commercial Ag tests on automated platforms and one POCT to detect SARS-CoV-2. We evaluated PCR-positive (n = 107) and PCR-negative (n = 303) respiratory swabs from asymptomatic and symptomatic patients at the end of the second pandemic wave in Germany (February–March 2021) as well as clinical isolates EU1 (B.1.117), variant of concern (VOC) Alpha (B.1.1.7) or Beta (B.1.351), which had been expanded in a biosafety level 3 laboratory. The specificities of automated SARS-CoV-2 Ag tests ranged between 97.0 and 99.7% (Lumipulse G SARS-CoV-2 Ag (Fujirebio): 97.03%, Elecsys SARS-CoV-2 Ag (Roche Diagnostics): 97.69%; LIAISON® SARS-CoV-2 Ag (Diasorin) and SARS-CoV-2 Ag ELISA (Euroimmun): 99.67%). In this study cohort of hospitalized patients, the clinical sensitivities of tests were low, ranging from 17.76 to 52.34%, and analytical sensitivities ranged from 420,000 to 25,000,000 Geq/ml. In comparison, the detection limit of the Roche Rapid Ag Test (RAT) was 9,300,000 Geq/ml, detecting 23.58% of respiratory samples. Receiver-operating-characteristics (ROCs) and Youden’s index analyses were performed to further characterize the assays’ overall performance and determine optimal assay cutoffs for sensitivity and specificity. VOCs carrying up to four amino acid mutations in nucleocapsid were detected by all five assays with characteristics comparable to non-VOCs. In summary, automated, quantitative SARS-CoV-2 Ag tests show variable performance and are not necessarily superior to a standard POCT. The efficacy of any alternative testing strategies to complement nucleic acid-based assays must be carefully evaluated by independent laboratories prior to widespread implementation.
Prognostic impact of nutritional and inflammation-based risk scores in follicular lymphoma in the era of anti-CD20 targeted treatment strategies
Authors: Gebauer Niklas , Mengler Britta , Kopelke Svenja , Frydrychowicz Alex , Fürschke Alexander , Hackenbroch Carsten , Bauer Arthur , Riecke Armin , von Bubnoff Nikolaus , Fetscher Sebastian , Witte Hanno M. 
Published: August 2021

Abstract
Background
The composition of the tumor microenvironment (TME) is conditioned by immunity and the inflammatory response. Nutritional and inflammation-based risk scores have emerged as relevant predictors of survival outcome across a variety of hematological malignancies.

Methods
In this retrospective multicenter trial, we ascertained the prognostic impact of established nutritional and inflammation-based risk scores [Glasgow Prognostic Score (GPS), C-reactive–protein/albumin ratio (CAR), neutrophil–lymphocyte ratio (NLR), prognostic nutritional index (PNI), and prognostic index (PI)] in 209 eligible patients with histologically confirmed CD20+ follicular lymphoma (FL) of WHO grade 1 (37.3%), 1–2 (16.3%), 2 (26.8%) or 3A (19.8%) admitted to the participating centers between January 2000 and December 2019. Characteristics significantly associated with overall or progression-free survival (OS, PFS) upon univariate analysis were subsequently included in a Cox proportional hazard model.

Results
In the study cohort, the median age was 63 (range 22–90 years). The median follow-up period covered 99 months. The GPS and the CAR were identified to predict survival in FL patients. The GPS was the only independent predictor of OS (p < 0.0001; HR 2.773; 95% CI 1.630–4.719) and PFS (p = 0.001; HR 1.995; 95% CI 1.352–2.944) upon multivariate analysis. Additionally, there was frequent occurrence of progression of disease within 24 months (POD24) in FL patients with a calculated GPS of 2.

Conclusion
The current results indicate that the GPS predicts especially OS in FL patients. Moreover, GPS was found to display disease-specific effects in regard to FL progression. These findings and potential combinations with additional established prognosticators should be further validated within prospective clinical trials.
UV/Vis absorption spectroelectrochemistry of folic acid
Authors: Olmo F. , Rodriguez A. , Colina A. , Heras A. 
Published: August 2021

AbstractUV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry.
A card game for designing activities for technology-enhanced learning in higher education
Authors: Mavroudi Anna , Almeida Teresa , Frennert Susanne , Laaksolahti Jarmo , Viberg Olga 
Published: August 2021

AbstractThe importance of providing mechanisms and tools that effectively support the transition from implicit to explicit representations of Learning Design has been emphasised by previous research in the field of Technology-Enhanced Learning (TEL). In addition, the benefits of Game-based learning approaches have been long documented in the educational research literature. The paper presents the design, implementation and evaluation of a card game that aims to support the design process of TEL activities in higher education. The game was tested by a group of 36 students and tutors (n = 36) in higher education during an interactive workshop. Feedback was asked by the participants using an anonymous survey. The results reveal that the participants a) are satisfied with the game process, b) appreciate the groupwork and interaction taking place, and c) believe that they used their communication and collaboration skills. The paper includes the description of the outputs of a group (i.e., the cards selected for their TEL scenario and their actual TEL scenario) to exemplify that it is possible to use the game in order to elicit or diagnose existing LD knowledge from the game participants. The paper concludes on the usefulness of the approach suggested, limitations, and plans for future work.
Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
Authors: Yamazaki Hiroyuki 
Published: August 2021

AbstractNature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has gradually become more challenging, and advances in novel strategic approaches are essential to evolve natural product chemistry. Our focus has been on surveying untouched marine resources and fermentation to enhance microbial productive performance. The first topic is the screening of marine natural products isolated from Indonesian marine organisms for new types of bioactive compounds, such as antineoplastics, antimycobacterium substances, and inhibitors of protein tyrosine phosphatase 1B, sterol O-acyl-transferase, and bone morphogenetic protein-induced osteoblastic differentiation. The unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented. This review presents an overview of our recent work accomplishments based on the MONOTORI study.
Graphic abstract
Intrusion errors moderate the relationship between blood glucose and regional cerebral blood flow in cognitively unimpaired older adults
Authors: Thomas Kelsey R. , Weigand Alexandra J. , Cota Isabel H. , Edmonds Emily C. , Wierenga Christina E. , Bondi Mark W. , Bangen Katherine J. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: August 2021

AbstractRegional cerebral blood flow (CBF) has a complex relationship with cognitive functioning such that cognitively unimpaired individuals at risk for Alzheimer’s disease (AD) may show regional hyperperfusion, while those with cognitive impairment typically show hypoperfusion. Diabetes and word-list intrusion errors are both linked to greater risk of cognitive decline and dementia. Our study examined associations between fasting blood glucose, word-list intrusion errors, and regional CBF. 113 cognitively unimpaired older adults had arterial spin labeling MRI to measure CBF in a priori AD vulnerable regions: medial temporal lobe (MTL), inferior parietal lobe (IPL), precuneus, medial orbitofrontal cortex (mOFC), and pericalcarine (control region). Hierarchical linear regressions, adjusting for demographics, vascular risk, and reference CBF region, examined the main effect of blood glucose on regional CBF as well as whether intrusions moderated this relationship. Higher glucose was associated with higher CBF in the precuneus (β = .134, 95% CI = .007 to .261,p = .039), IPL (β = .173, 95% CI = .072 to .276,p = .001), and mOFC (β = .182, 95% CI = .047 to .320,p = .009). There was no main effect of intrusions on CBF across regions. However, the glucose x intrusions interaction was significant such that having higher glucose levels and more intrusion errors was associated with reduced CBF in the MTL (β = -.186, 95% CI = -.334 to -.040,p = .013) and precuneus (β = -.146, 95% CI = -.273 to -.022,p = .022). These findings may reflect early neurovascular dysregulation, whereby higher CBF is needed to maintain unimpaired cognition in individuals with higher glucose levels. However, lower regional CBF in unimpaired participants with both higher glucoseandmore intrusions suggests a failure in this early compensatory mechanism that may signal a decrease in neural activity in AD vulnerable regions.
Topology Optimization Methods for 3D Structural Problems: A Comparative Study
Authors: Yago Daniel , Cante Juan , Lloberas-Valls Oriol , Oliver Javier 
Published: August 2021

AbstractThe work provides an exhaustive comparison of some representative families of topology optimization methods for 3D structural optimization, such as the Solid Isotropic Material with Penalization (SIMP), the Level-set, the Bidirectional Evolutionary Structural Optimization (BESO), and the Variational Topology Optimization (VARTOP) methods. The main differences and similarities of these approaches are then highlighted from an algorithmic standpoint. The comparison is carried out via the study of a set of numerical benchmark cases using industrial-like fine-discretization meshes (around 1 million finite elements), and Matlab as the common computational platform, to ensure fair comparisons. Then, the results obtained for every benchmark case with the different methods are compared in terms of computational cost, topology quality, achieved minimum value of the objective function, and robustness of the computations (convergence in objective function and topology). Finally, some quantitative and qualitative results are presented, from which, an attempt of qualification of the methods, in terms of their relative performance, is done.
Deutungen von Bildung frühpädagogischer Fachkräfte
Authors: Kaul Ina 
Published: August 2021

ZusammenfassungKindertageseinrichtungen gelten als Bildungsinstitutionen und leisten einen wesentlichen Beitrag zur Gestaltung des Aufwachsens von Kindern in Deutschland. Dabei spielen die frühpädagogischen Fachkräfte als Gestalter_innen und Ermöglicher_innen von Bildungsprozessen für Kinder eine entscheidende Rolle. Der Beitrag nimmt ihre Vorstellungen von Bildung und worauf sich diese gründen in den Blick.
Sozialpädagogische Qualifizierungen weiterdenken
Authors: Göddertz Nina 
Published: August 2021

ZusammenfassungViele Wege führen in die sozialpädagogische Praxis, doch nach wie vor stellt sich die Frage, wie sozialpädagogisches Handeln gelernt und gelehrt werden kann. Unter Bezugnahme auf kritisch bildungstheoretisch-fundierte Ansätze plädiert der Beitrag für eine Weiterentwicklung einer kritischen Didaktik der beruflichen Fachrichtung Sozialpädagogik.
Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered
Authors: Wiedemann Christoph , Obika Kingsley Benjamin , Liebscher Sandra , Jirschitzka Jan , Ohlenschlãger Oliver , Bordusa Frank 
Published: August 2021

AbstractEven though the human genome project showed that our DNA contains a mere 20,000 to 25,000 protein coding genes, an unexpectedly large number of these proteins remain functionally uncharacterized. A structural characterization of these “unknown” proteins may help to identify possible cellular tasks. We therefore used a combination of bioinformatics and nuclear magnetic resonance spectroscopy to structurally de-orphanize one of these gene products, the 108 amino acid human uncharacterized protein CXorf51A. Both our bioinformatics analysis as well as the $$^1$$

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N backbone and near-complete side-chain chemical shift assignments indicate that it is an intrinsically disordered protein.
Exploring loneliness and students’ sense of coherence (S-SoC) in the university setting
Authors: Limarutti Andrea , Maier Marco Johannes , Mir Eva 
Published: August 2021

AbstractBackground. Loneliness is a prevalent global public health issue, and this topic is also common among university students. From a health-related, resource-oriented approach like the salutogenic model, loneliness can be interpreted as a potential stressor. To cope effectively with this stressor, a strong Sense of Coherence is needed to mobilize resources like social support. Interventions to promote health and wellbeing within a university setting should include a salutogenic focus. However, currently, research regarding salutogenesis within the higher education setting is lacking. Therefore, this study aims to make the first attempt to explore the relation between loneliness and the Students' Sense of Coherence (S-SoC) among university students. Methods. An online questionnaire was sent out to all university students from the Carinthia University of Applied Sciences (CUAS), Austria. The online questionnaire was completed by 584 students (response rate of 28.86 %); 67.3% were female, and the average age was 25.16 years ( SD = 6.27 years). Full-time students made up 75.6% of the sample, and 84.6% were in a Bachelor's degree program. The S-SoC and the sub-scales comprehensibility, meaningfulness and manageability were measured by using the valid S-SoC scale (Brunner et al., 2009). Social and emotional loneliness was measured by using the six-item De Jong Gierveld loneliness scale (Jong Gierveld & van Tilburg, 2006). Spearman correlations and Kruskal-Wallis H-tests were computed among all loneliness and S-SoC sub-scales and other variables (e.g., age, sex...). Furthermore, a graphical model was used to show structural relationships between loneliness and S-SoC and control variables. Results. The results showed that students feeling moderate or severe general loneliness had lower S-SoC scores than students feeling low or not general lonely. Manageability was a pivotal point in this model, as it was inversely proportional to both measures of loneliness. Perceived social loneliness was reported most by men and part-time students. Conclusion. In order to fulfill study-related demands, students activate appropriate resources (e.g., social support), which corresponds to low social and emotional loneliness. However, in the development of health promoting interventions against loneliness among students, it would be necessary to consider sex and mode of study and to address health needs and problems with a salutogenic focus.
The Evolution of Life Satisfaction Throughout Childhood and Adolescence: Differences in Young People’s Evaluations According to Age and Gender
Authors: Aymerich Maria , Cladellas Ramon , Castelló Antoni , Casas Ferran , Cunill Mònica 
Published: August 2021

AbstractThe level of life satisfaction perceived during childhood and adolescence is an excellent indicator of healthy psychological emotional development. The main aim of this work is to study the levels of life satisfaction perceived by young people throughout their childhood and adolescence. To this end, an innovative retrospective approach is adopted that shows how the evolution of life satisfaction is perceived at different ages according to gender. The present study is based on a sample of 600 Spanish adolescents (58.1% girls; mean age = 16.64) who report the evolution of their life satisfaction from 6 years to 18, through the Life Satisfaction Chart (LSCh). The Goldberg Anxiety and Depression Scale (GADS) is also administered to record levels of anxiety and depression. The results indicate no gender differences in terms of life satisfaction during childhood. Levels of life satisfaction are significantly higher in childhood than in pre-adolescence and adolescence and a significant decrease in levels appearing towards the age of 11. As for gender, significant differences in life satisfaction appear from the age of 12, with girls being significantly more dissatisfied, more depressed and more anxious than boys. Current levels of anxiety and depression do not appear to interfere with retrospectively reported levels of life satisfaction throughout the developmental years studied, except among the female population, where minimal interference is detected. Life satisfaction retrospectively reported by young people shows a significant decrease after the age of 11 years, with greater emotional and psychological vulnerability after this age, mainly and notably among girls. The present results highlight the importance of psychological/affective care in the pre-adolescent and adolescent stages, especially among the female population.
Salvia celendina (Lamiaceae), a new species from Peru
Authors: Wood John R. I. , Uría Rolando 
Published: August 2021

SummaryA new species of Salvia (S. celendina J.R.I.Wood & Uría) is described from the Marañón valley hotspot in northern Peru. The new species is illustrated with photographs and its distribution is mapped. Notes on its cultivation and distinctive characteristics are provided.
Vielfalt im Sportunterricht
Authors: Mihajlovic Christopher 
Published: August 2021

ZusammenfassungDer Inklusionsdiskurs bestimmt derzeit nicht nur in Deutschland, sondern auch in vielen anderen Ländern die schulische und fachdidaktische Diskussion. Die internationalen Ansätze im Kontext des inklusiven Sportunterrichts wurden bisher allerdings nur ansatzweise im deutschsprachigen Raum erschlossen. Dieser Beitrag nimmt an dieser Forschungslücke anknüpfend das finnische Schulsystem in den Blick und analysiert, welche Rolle das Thema Diversität im aktuell gültigen Kerncurriculum für das Fach Sport spielt. Dabei liegt der Fokus auf den Diversitätsdimensionen „Gender“, „Interkulturalität“ und „sonderpädagogischer Förderbedarf“. Die Einnahme der finnischen Perspektive erscheint insofern lohnend, da Finnland bereits über einen reichhaltigen Erfahrungsschatz in der inklusiven Beschulung verfügt und die Analyse der curricularen Vorgaben den soziokulturellen Kontext sowie die spezifischen pädagogischen und fachdidaktischen Traditionen für den deutschsprachigen sportpädagogischen Diskurs erschließen können. Die Analyse zeigt auf, dass die Wertschätzung von Diversität auch für den Schulsport eingefordert wird, allerdings bleibt an vielen Stellen offen, wie der konkrete Umgang mit den untersuchten Diversitätsdimensionen auf der Unterrichtsebene erfolgen kann. Der Beitrag plädiert für die Notwendigkeit weiterer Forschungsvorhaben, die eine internationale Perspektive auf den Inklusionsdiskurs legen und länderspezifische Rahmenbedingungen vermehrt berücksichtigen.
Recent advances in porous microneedles: materials, fabrication, and transdermal applications
Authors: Bao Leilei , Park Jongho , Bonfante Gwenaël , Kim Beomjoon 
Published: August 2021

AbstractIn the past two decades, microneedles (MNs), as a painless and simple drug delivery system, have received increasing attention for various biomedical applications such as transdermal drug delivery, interstitial fluid (ISF) extraction, and biosensing. Among the various types of MNs, porous MNs have been recently researched owing to their distinctive and unique characteristics, where porous structures inside MNs with continuous nano- or micro-sized pores can transport drugs or biofluids by capillary action. In addition, a wide range of materials, including non-polymers and polymers, were researched and used to form the porous structures of porous MNs. Adjustable porosity by different fabrication methods enables the achievement of sufficient mechanical strength by optimising fluid flows inside MNs. Moreover, biocompatible porous MNs integrated with biosensors can offer portable detection and rapid measurement of biomarkers in a minimally invasive manner. This review focuses on several aspects of current porous MN technology, including material selection, fabrication processes, biomedical applications, primarily covering transdermal drug delivery, ISF extraction, and biosensing, along with future prospects as well as challenges.
Graphical abstract