bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated flood risk assessment of the Arial Khan River under changing climate using IPCC AR5 risk framework
Authors: Roy Binata , Khan Md. Sabbir Mostafa , Saiful Islam A. K. M. , Khan Md. Jamal Uddin , Mohammed Khaled 
Published: August 2021

Abstract
Bangladesh is situated at the confluence of GBM basins, with 90% of the basin area locating outside the country. Future climate change will lead to intense, prolonged, and frequent floods in Bangladesh. An integrated flood risk assessment that transforms flood risks from transboundary river basins to the local administrative level is necessary. A 1D/2D hydrodynamic model is developed for flood vulnerable Arial Khan River feed by basin-scale hydrologic model for low (RCP2.6) and high (RCP8.5) climate scenarios. An increasing trend in flood depth, duration, and area is observed from the early (2020s) to the end (2080s) of the century for both scenarios. The difference between both RCPs is minimal from the 2020s to 2050s but becomes very pronounced in the 2080s. The depth-duration-area with equal weightage provides better hazard results for the area. Flood risk is assessed using the IPCC AR5 framework incorporating vulnerability and exposure. Some medium-hazard zones fall into high-risk zones due to high exposure and vulnerability to flooding. The areas along the left reach are found more hazard-prone, while the areas on the right side are more risk-prone in the 2080s of RCP8.5. The hazard/risk maps will help policymakers identify priority areas for planning a sustainable flood management strategy.
Life cycle water footprint assessment of concrete production in Northwest China
Authors: Ding Chao , Dong Wenxiu , Zhang Ailin , Wang Zhenhua , Zhao Na , Chen Rong , Fu Hanliang 
Published: August 2021

Abstract
Concrete requires a large amount of water throughout the product life cycle. This study constructs a comprehensive evaluation model of the life cycle water footprint (LCWF) of concrete production. It calculates the LCWF of concrete in Northwest China. The main conclusions are: (1) The vast water consumption of the concrete industry is closely related to VWF, which is the focus of LCWF assessment. The first three significant factors are WF of Coarse aggregate, Meals, and Cement. (2) the overproduction of cement is 15,731 × 104t, which results in the excessive consumption of water resources of 24,035 × 104m3. Excessive water consumption in the domestic cement trade is equivalent to an outflow of water resources. (3) The water stress index (WSI) of Northwest China is 0.67 (in Heavy pressure). The WSI of Qinghai (0.05) and Shaanxi (0.5) are in Mild pressure and Moderate pressure, respectively, while the WSI of Gansu is 0.67 (in Heavy pressure). It is worth noting that the WSI of Ningxia (9.01) and Xinjiang (1.28) are under Extreme pressure. The sustainable development of water resources in Northwest China is under heavy pressure, exacerbated by the growth of the concrete and cement industries.
Review and Comparative Analysis of Machine Learning-based Predictors
for Predicting and Analyzing Anti-angiogenic Peptides
Authors: Charoenkwan Phasit , Chiangjong Wararat , Hasan Md Mehedi , Nantasenamat Chanin , Shoombuatong Watshara 
Published: August 2021

Abstract:
Cancer is one of the leading causes of death worldwide and the underlying angiogenesis
represents one of the hallmarks of cancer. Efforts are already under way for
the discovery of anti-angiogenic peptides (AAPs) as a promising therapeutic route, which
tackle the formation of new blood vessels. As such, the identification of AAPs constitutes
a viable path for understanding their mechanistic properties pertinent for the discovery of
new anti-cancer drugs. In spite of the abundance of peptide sequences in public databases,
experimental efforts in the identification of anti-angiogenic peptides have progressed very
slowly owing to high expenditures and laborious nature. Owing to its inherent ability to
make sense of large volumes of data, machine learning (ML) represents a lucrative technique
that can be harnessed for peptide-based drug discovery. In this review, we conducted
a comprehensive and comparative analysis of ML-based AAP predictors in terms of
their employed feature descriptors, ML algorithms, cross-validation methods and prediction
performance. Moreover, the common framework of these AAP predictors and their
inherent weaknesses are also discussed. Particularly, we explore future perspectives for
improving the prediction accuracy and model interpretability, which represent an interesting
avenue for overcoming some of the inherent weaknesses of existing AAP predictors.
We anticipate that this review would assist researchers in the rapid screening and identification
of promising AAPs for clinical use.
Structure-based Design of Anti-cancer Vaccines: The Significance of
Antigen Presentation to Boost the Immune Response
Authors: Asín Alicia , García-Martín Fayna , Busto Jesús Hector , Avenoza Alberto , Peregrina Jesús Manuel , Corzana Francisco 
Published: August 2021

:
Immunotherapy, alone or in combination with other therapies, is widely used
against cancer. Glycoprotein Mucin 1 (MUC1), which is overexpressed and aberrantly
glycosylated in tumor cells, is one of the most promising candidates to engineer new cancer
vaccines. In this context, the development of stable antigens that can elicit a robust
immune response is mandatory. Here, we describe the design and in vivo biological evaluation
of three vaccine candidates based on MUC1 glycopeptides that comprise unnatural
elements in their structure. By placing the Tn antigen (GalNAcα-O-Ser/Thr) at the center
of the design, the chemical modifications include changes to the peptide backbone, glycosidic
linkage, and carbohydrate level. Significantly, the three vaccines elicit robust immune
responses in mice and produce antibodies that can be recognized by several human
cancer cells. In all cases, a link was established between the conformational changes induced
by the new elements in the antigen presentation and the immune response induced
in mice. According to our data, the development of effective MUC1-based vaccines
should use surrogates that mimic the conformational space of aberrantly glycosylated
MUC1 glycopeptides found in tumors.
Beta-glucans is a Potential Inhibitor of Ovarian Cancer: Based on Molecular and Biological Aspects
Authors: Hallajzadeh Jamal , Sadoughi Fatemeh , Asemi Zatollah , Mansournia Mohammad Ali , Yousefi Bahman 
Published: August 2021

:Ovarian cancer is a lethal type of cancer which is initiated to the ovaries and affects 1 out of every 75 women. Due to the high number of deaths (almost 152,000) related to this cancer, it seems that novel efficient therapeutic methods are required in this field. Beta-glucans are a type of glucose linear polymers which have been proven to have a lot of advantageous activities. Recently, investigations have declared that these polysaccharides have the potential to be used as anti-cancer drugs. These agents are able to affect several mechanisms such as inflammation and apoptosis, and that is how cancers are prone to be affected by them. In this review, we attempt to investigate the role of beta-glucans on ovarian cancer. We hope that this paper would give some novel insights into the field of ovarian cancer treatment.
Designing Consumer Health Information Technology to Support Biform and Articulation Work: A Qualitative Study of Diet and Nutrition Management as Patient Work
Authors: Rogers Courtney C , Moutinho Jr Thomas J , Liu Xiaoyue , Valdez Rupa S 
Published: August 2021

Background
Diet and nutrition management is an integral component of Crohn disease (CD) management. This type of management is highly variable and individualized and, thus, requires personalized approaches. Consumer health information technology (CHIT) designed to support CD management has typically supported this task as everyday life work and, not necessarily, as illness work. Moreover, CHIT has rarely supported the ways in which diet and nutrition management requires coordination between multiple forms of patient work.

Objective
The purpose of this study was to investigate diet and nutrition management as biform work, identify components of articulation work, and provide guidance on how to design CHIT to support this work.

Methods
We performed a qualitative study in which we recruited participants from CD-related Facebook pages and groups.

Results
Semistructured interviews with 21 individuals showed that diet and nutrition management strategies were highly individualized and variable. Four themes emerged from the data, emphasizing the interactions of diet and nutrition with physical, emotional, information, and technology-enabled management.

Conclusions
This study shows that the extent to which diet and nutrition management is biform work fluctuates over time and that articulation work can be continuous and unplanned. The design guidance specifies the need for patient-facing technologies to support interactions among diet and nutrition and other management activities such as medication intake, stress reduction, and information seeking, as well as to respond to the ways in which diet and nutrition management needs change over time.
Modulation of Bone and Joint Biomarkers, Gut Microbiota, and Inflammation Status by Synbiotic Supplementation and Weight-Bearing Exercise: Human Study Protocol for a Randomized Controlled Trial
Authors: Ilesanmi-Oyelere Bolaji Lilian , Roy Nicole C , Kruger Marlena C 
Published: August 2021

Background
There is strong evidence suggesting that prebiotics and probiotics regulate gut microbiota, reducing inflammation and thereby potentially improving bone health status. Similarly, mechanistic evidence suggests that either low-impact or high-impact weight-bearing exercises improve body composition and consequently increase bone mineral density in individuals with osteoporosis and osteoarthritis.

Objective
This study aims to investigate the effects of a synbiotic (probiotic+prebiotic) supplementation, an exercise intervention, or a combination of both on gut microbiota, inflammation, and bone biomarkers in postmenopausal women.

Methods
A total of 160 postmenopausal women from New Zealand will be recruited and randomized to one of four interventions or treatments for 12 weeks: control, synbiotic supplementation, exercise intervention, or synbiotic supplementation and exercise. The primary outcome measure is the bone and joint biomarkers at baseline and week 12, whereas the gut microbiota profile and inflammatory cytokine measurements will serve as the secondary outcome measures at baseline and week 12. Baseline data and exercise history will be used to assess, allocate, and stratify participants into treatment measures.

Results
Recruitment of participants will begin in September 2021, and the anticipated completion date is June 2022.

Conclusions
To the best of our knowledge, this will be the first randomized controlled trial to analyze the effects of both a synbiotic supplement and an exercise intervention in postmenopausal women. On the basis of the results obtained, a combination of synbiotic supplements and exercise might serve as a noninvasive approach to manage and/or improve body composition and bone health in postmenopausal women.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12620000998943p; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380336&isClinicalTrial=False
Consenso colombiano de expertos sobre recomendaciones basadas en evidencia para el diagnóstico y tratamiento de alteraciones del metabolismo óseo y mineral en pacientes con enfermedad renal crónica
Authors: Coronado Daza Jorge Antonio 
Published: August 2021

Introducción: Las alteraciones del metabolismo óseo y mineral asociado a la enfermedad renal crónica (AMOM-ERC) es una de las complicaciones más frecuentes e importantes que afecta la calidad de vida de pacientes con enfermedad renal crónica y sus familias y, además, contribuye al aumento de la morbimortalidad cardiovascular.
Método: A partir de una revisión sistemática de literatura en las bases de datos Embase y Medline vía Pubmed, grupos desarrolladores de evidencia y sociedades científicas, se formularon recomendaciones preliminares por el grupo desarrollador que fueron consultadas a un colectivo experto de nefrología, endocrinología, geriatría, reumatología, medicina interna y cardiología, a través del método Delphi modificado.
Resultados: Se presentan 62 recomendaciones sobre diagnóstico y tratamiento de AMOM-ERC definidas por consenso entre 51 expertos clínicos y el grupo desarrollador. El rango de aprobación de las recomendaciones oscilo entre 80.9% y 100%.
Conclusión: Las recomendaciones presentadas permiten a los expertos clínicos la toma de decisiones clínicas cotidianas basadas en evidencia sobre el diagnóstico y el tratamiento de las alteraciones del metabolismo óseo y mineral en pacientes con enfermedad renal crónica en Colombia.
Post Hoc Analysis Evaluating the Impact of Antihyperglycemic Background Therapies on Attainment of A1C Targets Without Hypoglycemia in the ACHIEVE Control Pragmatic, Real-Life Study
Authors: Bailey Timothy S. , Evenou Pierre , Gill Jasvinder , Berhanu Paulos , Raymond Romain , Strong Jodi , Wright Eugene E. 
Published: August 2021

Background
ACHIEVE Control, a prospective, open-label, randomized, pragmatic, real-life study in insulin-naive people with type 2 diabetes (A1C 8.0–11.0%), demonstrated superiority of insulin glargine 300 units/mL (Gla-300) versus first-generation standard-of-care basal insulin (SOC-BI; glargine 100 units/mL or insulin detemir) in achieving individualized A1C targets without documented symptomatic (glucose ≤3.9 mmol/L [≤70 mg/dL] or &lt;3.0 mmol/L [&lt;54 mg/dL]) or severe hypoglycemia (American Diabetes Association level 3) at 6 months. Noninsulin antihyperglycemic background therapies are commonly used; however, sulfonylureas may increase hypoglycemia risk. This post hoc analysis assessed outcomes according to background therapy.

Methods
Subgroup analyses were performed per concomitant use/nonuse of sulfonylureas, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase 4 inhibitors, or sodium–glucose cotransporter 2 (SGLT2) inhibitors. End points (6 and 12 months) included A1C target attainment without documented symptomatic or severe hypoglycemia, A1C target attainment, and absence of documented symptomatic or severe hypoglycemia.

Results
Odds ratios (ORs) at 12 months mostly favored Gla-300 versus SOC-BI across subgroups except in analysis of SGLT2 inhibitors, in which ORs were similar. Among sulfonylurea users, ORs at 12 months strongly favored Gla-300 versus SOC-BI for all end points, particularly A1C target achievement without documented symptomatic hypoglycemia (glucose ≤3.9 mmol/L [≤70 mg/dL]; OR 1.25, 95% CI 1.02–1.53) or severe hypoglycemia and achievement of no documented symptomatic hypoglycemia (glucose &lt;3.0 mmol/L [&lt;54 mg/dL]; OR 1.25, 95% CI 1.02–1.52) or severe hypoglycemia.

Conclusion
The results suggest that, in insulin-naive people with type 2 diabetes, Gla-300 is effective with a risk of hypoglycemia that is lower than or similar to that of SOC-BI regardless of background medication. Individuals receiving concomitant sulfonylureas were more likely to remain without symptomatic or severe hypoglycemia with Gla-300.
A study of work stress and coping among primary school teachers in the Wellington region
Authors: Jain Shilpa 
Published: August 2021

This research examines the perception of work stress among primary school teachers in the Wellington region. Specifically, it focuses on the way teachers perceive work stress, the contributing factors and the coping strategies employed. Interpretative phenomenological analysis is the qualitative approach and methodology chosen to examine the way teachers make sense of their stress experiences. The educational sector in New Zealand has undergone enormous legislative and organisational change and in the recent past there have been nationwide primary school teacher strikes. While research on teacher stress in New Zealand in relation to the 1989 major reforms has been published, there has been little recent qualitative research on work stress in primary school teachers.
This study shows that these teachers experience moderate to high levels of stress because of work overload, the multiplicity of sources of stress, the emotional demands of the role and the frustration and constraints they face in role performance. Even so, these teachers derive satisfaction from the core job of teaching and utilise positive coping strategies to manage their stress and work demands, with most of them intending to stay in the role. However, the sustainability of the role of teaching is a concern, as societal misperceptions about teaching and lack of respect for them pose challenges for those continuing in the profession long term. This study contributes to the base literature on teacher stress in the New Zealand context and offers recommendations for supporting the well-being of primary school teachers.
The Potential of Vā Part 5: Research-Informed Design
Authors: Simati-Kumar Benita 
Published: August 2021

The article presented is part of a series of chapters that composed an exegesis, submitted in fulfilment of the requirements for the degree of Doctor of Philosophy. The series is a narrative of discovery through practice-led research. Each article reveals its purpose and significance that leads into the next series, which then eventuate to that final design proposal.
The exegesis is presented in this format, to break down the components that assisted in practice-led research. Each article can be read and unpacked on its own as a learning tool. The purpose of this edited series is for the exegesis to be more accessible and adaptable creatively to those being introduced to practice-led research.
The Potential of Vā Part 5: Research-informed design, critically unpacks significant concepts. These include vā, materiality and processes, lalaga, lalava, lines of location, blended backgrounds, imagery and colour and experiments underpinning the research design.
The importance of archiving Pacific indigenous artefacts is based on the importance of archiving Pacific knowledge. Sāmoan people have adapted their fa’aSāmoa in the diaspora for the advancement of their culture and people. This provides the basis for which I argue that Pacific peoples should seek out new methods to preserve their artefacts. With reference to the Lala-VĀ model, the interrelationship of family, language, genealogies, chiefly systems, religion, ceremonies and other family obligations is illustrated by the link between artefacts and other aspects of Pacific culture and tradition. The comprehensive nature of the artefacts and the stories that accompany the visual image ensure that the digital archive is all-inclusive.
Identifikasi Suara Pada Sistem Presensi Karyawan Dengan Metode Ekstraksi Ciri MFCC
Authors: Widodo Yuwono Fitri , Sunardi Sunardi , Fadlil Abdul 
Published: August 2021

Biometrik adalah ilmu yang mempelajari pola ciri-ciri untuk mengenali atau mengidentifikasi manusia berdasarkan satu atau lebih dari bagian tubuh manusia, baik ciri-ciri kimia, fisik, maupun tingkah laku, seperti wajah, sidik jari, suara, geometri tangan, ataupun iris mata. Saat ini sudah berkembang teknologi menggunakan suara untuk dijadikan sebuah aplikasi yang memudahkan manusia. Proses identifikasi suara sangat diperlukan untuk mengetahui keakuratan suara berdasarkan ciri yang dimiliki, karena beberapa manusia memiliki kemiripan dalam berucap. Pada penelitian ini bertujuan untuk mengetahui pola suara berdasarkan ucapan. Metode yang digunakan untuk identifikasi suara menggunakan metode ekstraksi firur Mel-Frequency Cepstral Coefficients (MFCC), merupakan metode ekstraksi fitur yang mendekati sistem pendengaran manusia dan mampu untuk mengenali pola ucapan.
Penerapan Sistem Informasi Manajemen Perizinan Online (Simponie) Berbasis Website Dengan Menggunakan Ci Framework
Authors: Friandi Sendy Zul , Angga Tubagus , Hikmah Nurul , Budiman Fadjar , Fitria Sifa 
Published: August 2021

Pemerintah Kota Tangerang Selatan dalam melaksanakan kegiatan pelayanan publik yang secara online dan terbuka khususunya dibidang perizinan. Pada Peraturan Daerah Kota Tangerang Selatan Nomor 61 tahun 2016 tentang Kedudukan, Struktur Organisasi, Tugas, Fungsi dan Tata Kerja dibentuklah Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu (DPMPTSP). Awal mula terbentuknya DPMPTSP dimana sistem masih berjalan manual dan masih terdapati praktek pungli dilakukan oknum calo. Untuk mengurangi praktek pungli DPMPTSP melakukan terobosan baru yakni membuat sistem informasi yang berbasis website mudah dijangkau secara online dan terbuka. Untuk implementasi Sistem Informasi Manajemen Perizinan Online (SIMPONIE) tersebut, peneliti menganalisis kendala yang ada pada Dinas Penanaman Modal dan PTSP dengan beberapa Metode yang terdiri dari Metode Pengumpulan data, Metode Konsep Analisa Sistem Menggunakan SDLC (Systems Development Life Cycle) tipe Waterfall, dan Metode Rancangan Sistem Menggunakan UML (Unified Modeling Language) dan CI Framework.
PECULIARITIES OF UNIVERSAL BODY DESIGN FOR INNOVATION REFRIGERATOR CARS
Authors: Voron Oleg 
Published: August 2021

There are considered analysis results of stress-strain state in the load-bearing structure of three versions of refrigerator cars with different arrangement solutions of refrigerating-heating plants (RHP) and a thermos car at its cooling with liquid nitrogen.
By means of the “APM WinMachine” application there are presented model parameters of a basic universal body. The analysis of calculation results has shown sufficient strength and potentialities for updating an available car metal structure for the application as a universal body of a refrigerator car.
Work purpose: the estimation of a stress-strain state in the load-bearing structure of a basic body for insulated cars of different types of refrigerator- and thermos cars.
Investigation methods: for the analysis of the stress-strain state in a load-bearing structure in three versions of the bodies of refrigerator- and thermos cars under loads with “Normal” modes there was used the “APM WinMachine” software complex realizing a finite element method.
Results and novelty: for the first time there are offered arrangement solutions for the location of refrigeration-heating plants earlier not used for refrigeration rolling-stock (RRS). A stress-strain state of the body of the thermos car at the impact of overpressure upon it of gaseous nitrogen evaporated in cargo compartment is estimated.
Conclusions: the analysis of calculation results for all three versions of the RHP arrangement and a solid body of a thermos car has shown sufficient strength and possibility regarding simple updating an available body metal structure which may be used as a universal car set.