bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explaining ethnic variations in adolescent mental health: a secondary analysis of the Millennium Cohort Study
Authors: Ahmad Gargie , McManus Sally , Bécares Laia , Hatch Stephani L. , Das-Munshi Jayati 
Published: October 2021

AbstractPurposeThe relationship between ethnicity and adolescent mental health was investigated using cross-sectional data from the nationally representative UK Millennium Cohort Study.MethodsParental Strengths and Difficulties Questionnaire reports identified mental health problems in 10,357 young people aged 14 (n = 2042 from ethnic minority backgrounds: Mixedn = 492, Indiann = 275, Pakistanin = 496, Bangladeshin = 221, Black Caribbeann = 102, Black Africann = 187, Other Ethnic Groupn = 269). Univariable logistic regression models investigated associations between each factor and outcome; a bivariable model investigated whether household income explained differences by ethnicity, and a multivariable model additionally adjusted for factors of social support (self-assessed support, parental relationship), participation (socialising, organised activities, religious attendance), and adversity (bullying, victimisation, substance use). Results were stratified by sex as evidence of a sex/ethnicity interaction was found (P = 0.0002).ResultsThere were lower unadjusted odds for mental health problems in boys from Black African (OR 0.15, 95% CI 0.04–0.61) and Indian backgrounds (OR 0.42, 95% CI 0.21–0.86) compared to White peers. After adjustment for income, odds were lower in boys from Black African (OR 0.10, 95% CI 0.02–0.38), Indian (OR 0.40, 95% CI 0.21–0.77), and Pakistani (OR 0.49, 95% CI 0.27–0.89) backgrounds, and girls from Bangladeshi (OR 0.18, 95% CI 0.05–0.65) and Pakistani (OR 0.63, 95% CI 0.41–0.99) backgrounds. After further adjustment for social support, participation, and adversity factors, only boys from a Black African background had lower odds (OR 0.16, 95% CI 0.03–0.71) of mental health problems.ConclusionsHousehold income confounded lower prevalence of mental health problems in some young people from Pakistani and Bangladeshi backgrounds; findings suggest ethnic differences are partly but not fully accounted for by income, social support, participation, and adversity. Addressing income inequalities and socially focused interventions may protect against mental health problems irrespective of ethnicity.
The parallel convergence of income and educational achievements: joint distribution dynamics
Authors: Wójcik Piotr Tadeusz 
Published: October 2021

AbstractHuman capital is an important factor of economic growth. Previous studies show that convergence patterns of income and education differ on a regional level. The purpose of this article is to verify whether there is statistical relationship between the patterns of educational achievements convergence and income convergence processes in Poland on the regional and local level. The paper describes and applies an innovative way for the formal verification of similarities in convergence patterns on the basis of transition matrices and kernel density estimation. The analysis is performed on Polish data for educational achievements (lagged exam results of 15-year old pupils) and income per capita worker on the regional and local level for the period 2003–2015. Despite the occurrence of (weak) convergence for both phenomena, each has a different course. Therefore, the processes of the income convergence and educational achievements convergence in Poland were not parallel.
Real-world outcomes of regorafenib combined with immune checkpoint inhibitors in patients with advanced or metastatic microsatellite stable colorectal cancer: A multicenter study
Authors: Yang Kaili , Han Lu , Wu Shikai , Qu Xiujuan , Li Qin , Zhao Chuanhua , Zhou Jing , Jin Xuan , Wang Yusheng , Yan Dong , Cheng Zhiqiang , Hua Yuwei , Zhang Yan , Ge Yang , Sun Jinghua , Deng Wei , Zhao Lin , Zhao Yunbo 
Published: October 2021

Abstract
Background
Treatment strategies are limited for patients with chemotherapy refractory microsatellite stable (MSS) colorectal cancer. We aim to evaluate the efficacy and safety of immune checkpoint inhibitors (ICIs) combined with regorafenib in this population in routine clinical practice.

Methods
We retrospectively analyzed patients with advanced or metastatic colorectal cancer who received at least one dose of ICIs combined with regorafenib in 14 Chinese medical centers. The primary outcome was objective response rate (ORR). This study was registered at ClinicalTrials.gov on February 2020 (NCT04771715).

Results
Eighty-four patients received ICIs combined with regorafenib from January 2019 to January 2021. Most patients (91%) received two or more systemic treatment lines before the study treatment. Seventy-six patients (90%) had confirmed MSS status. At a median follow-up of 5.5 months, four patients achieved partial response (5%) and 37 patients achieved stable disease (45%) as the best response. The median progression-free survival (PFS) was 3.1 months, and the median overall survival was 17.3 months. Eleven patients (13%) remained progression-free for more than 6 months. Baseline liver metastasis (HR 1.98, 95%CI 1.07–3.69, P = 0.03) and neutrophil–lymphocyte ratio (NLR) of ≥ 1.5 (HR 2.83, 95%CI 1.00–7.98, P = 0.05) were associated with shorter PFS in multivariate analysis. Grade 3 or higher treatment-related adverse events (TRAEs) occurred in 16 patients (19%).

Conclusion
The combination of ICIs with regorafenib can be a valuable treatment option for a proportion of patients with chemotherapy refractory MSS colorectal cancer. Patients with no liver metastasis and a low NLR at baseline may derive most benefit from this strategy.
Winter and spring atmospheric rivers in High Mountain Asia: climatology, dynamics, and variability
Authors: Nash Deanna , Carvalho Leila M. V. , Jones Charles , Ding Qinghua 
Published: October 2021

AbstractAtmospheric rivers (ARs) that reach the complex terrain of High Mountain Asia (HMA) cause significant hydrological impacts for millions of people. While ARs are often associated with precipitation extremes and can cause floods and debris flows affecting populated communities, little is known about ARs that reach as far inland as HMA. This paper characterizes AR types and investigates dynamical mechanisms associated with the development of ARs that typically affect HMA. Combined empirical orthogonal function (cEOF) analysis using integrated water vapor transport (IVT) is applied to days where an AR reaches HMA. K-means cluster analysis applied to the first two principal components uncovered three subtypes of AR events with distinct synoptic characteristics during winter and spring months. The first subtype increases precipitation and IVT in Western HMA and is associated with a zonally oriented wave train propagating within the westerly jet waveguide. The second subtype is associated with enhanced southwesterly IVT, anomalous upper-level cyclonic circulation centered on 45$$^\circ $$

∘

E, and precipitation in Northwestern HMA. The third subtype shows anomalous precipitation in Eastern HMA and southwesterly IVT across the Bay of Bengal. Interannual variations in the frequency of HMA ARs and relationships with various teleconnection patterns show that western HMA AR subtypes are sensitive to well-known remote large-scale climate factors, such as the El Niño Southern Oscillation, Arctic Oscillation, and the Siberian High. These results provide synoptic characterization of the three types of ARs that reach HMA and reveal the previously unexplored significance of their contribution to winter and spring precipitation.
Role of integrins in the metastatic spread of high-grade serous ovarian cancer
Authors: Krajnak Slavomir , Jäkel Jörg , Anić Katharina , Schwab Roxana , Schmidt Marcus , Hasenburg Annette , Roth Wilfried , Brenner Walburgis , Battista Marco Johannes 
Published: October 2021

Abstract
Purpose
Integrins may be involved in the metastatic spread of high-grade serous ovarian cancer (HGSOC) which determines the therapeutical approach and prognosis. We investigated the integrin expression in primary tumor and metastases of advanced HGSOC.

Methods
The expression of integrin α2, α4, α5, α6, and β1 was assessed by immunostaining in tumor samples of the ovary, omentum, and peritoneum of each patient. Differences in integrin expression among tumor localizations and their association with clinicopathological parameters were examined by Fisher’s exact test. The impact of integrin expression on progression-free survival (PFS) and overall survival (OS) was examined by Cox regression and Kaplan–Meier analyses.

Results
Hundred and thirteen tumor samples of 40 HGSOC patients were examined. The expression of the integrins did not differ between the three tumor localizations (all p values > 0.05) with the exception of high expression of integrin α4 in primary tumor and omentum (52.5% versus 47.5%, p = 0.008) and primary tumor and peritoneum (52.5% versus 47.5%, p = 0.050). High expression of integrin α4 in peritoneum was associated with poorer PFS (HR 2.02 95% CI 1.01–4.05, p = 0.047), younger age (p = 0.047), and death (p = 0.046). Median PFS in patients with high expression of integrin α4 was 13.00 months, whereas median PFS in patients without high expression of integrin α4 was 21.00 months (p = 0.040). Expression of other integrins did not correlate with PFS or OS.

Conclusion
Expression of integrin α4 may be altered during the metastatic spread of HGSOC and affect prognosis, whereas expression of integrin α2, α5, α6, and β1 did not reveal any prognostic value.
Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer
Authors: Arnold Sabrina , Kortland Jan , Maltseva Diana V. , Nersisyan Stepan A. , Samatov Timur R. , Lezius Susanne , Tonevitsky Alexander G. , Milde-Langosch Karin , Wicklein Daniel , Schumacher Udo , Stürken Christine 
Published: October 2021

AbstractPurposeThe transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates the expression of E- and P-selectin ligands. Such selectin ligands are important members of the leukocyte adhesion cascade, which govern the adhesion and transmigration of cancer cells into the stroma of the host organ of metastasis. As so far, no in vivo data are available, this study was designed to elucidate the role of Fra-2 expression in a spontaneous breast cancer metastasis xenograft model.MethodsThe effect of Fra-2 overexpression in two stable Fra-2 overexpressing clones of the human breast cancer cell line MDA MB231 on survival and metastatic load was studied after subcutaneous injection into scid and E- and P-selectin-deficient scid mice.ResultsFra-2 overexpression leads to a significantly shorter overall survival and a higher amount of spontaneous lung metastases not only in scid mice, but also in E- and P-deficient mice, indicating that it regulates not only selectin ligands, but also selectin-independent adhesion processes.ConclusionThus, Fra-2 expression influences the metastatic potential of breast cancer cells by changing the expression of adhesion molecules, resulting in increased adherence to endothelial cells in a breast cancer xenograft model.
A technique for constructing diverting loop ileostomy to prevent outlet obstruction after rectal resection and total colectomy: a retrospective single-center study
Authors: Takehara Yusuke , Nakagawa Mihoko , Kobayashi Hiroaki , Kakisako Kensuke , Takano Yojiro , Seki Junichi , Shimada Shoji , Nakahara Kenta , Mukai Shumpei , Enami Yuta , Sawada Naruhiko , Ishida Fumio , Kudo Shin-ei 
Published: October 2021

Abstract
Purpose
Preventing outlet obstruction associated with a diverting stoma is important. Previously, we constructed a diverting loop ileostomy with the proximal limb of the small intestine on the caudal side, namely the oral inferior (OI) method. However, to address the issue of twisting and stenosis of the small intestine, we recently constructed a diverting loop ileostomy with the proximal limb on the cranial side, namely the oral superior (OS) method. We compared the incidence of outlet obstruction between the two methods.

Methods
The subjects of this retrospective study were 133 patients who underwent colorectal resection or total colectomy, with D2 or more lymph node dissection and diverting loop ileostomy construction, between April, 2001 and December, 2018, at our hospital. The OI method was performed in 54 patients and the OS method was performed in 79 patients.

Results
In the OS group, a history of laparotomy, neoadjuvant therapy, clinical stage III, and the use of anti-adhesion materials were more common, whereas blood loss and the incidence of outlet obstruction were significantly lower. Multivariate analysis identified only OS placement as a significant factor for reducing the incidence of outlet obstruction.

Conclusion
When constructing a diverting loop ileostomy, placing the proximal limb on the cranial side is important.
Operant conditioning in antlion larvae and its impairment following exposure to elevated temperatures
Authors: Miler Krzysztof , Scharf Inon 
Published: October 2021

AbstractAlthough ambush predators were previously considered limited in their cognitive abilities compared to their widely foraging relatives, there is accumulating evidence it does not hold true. Pit-building antlions are already known to associate vibrations in the sand with the arrival of prey. We used a T-maze and successfully trained antlions to turn right or left against their initial turning bias, leading to a suitable substrate for digging traps. We present here the first evidence for operant conditioning and T-maze solving in antlions. Furthermore, we show that exposure of second instar larvae to an elevated temperature led to impaired retention of what was learned in a T-maze when tested after moulting into the third instar, compared to larvae raised under a more benign temperature. We suggest that climate change, involving an increase in mean temperatures as well as rare events (e.g., heatwaves) might negatively affect the retention of operant conditioning in antlions, alongside known, more frequently studied effects, such as changes in body size and distribution.
GPS, GLONASS, and Galileo orbit geometry variations caused by general relativity focusing on Galileo in eccentric orbits
Authors: Sośnica Krzysztof , Bury Grzegorz , Zajdel Radosław , Ventura-Traveset Javier , Mendes Luis 
Published: October 2021

AbstractThree main effects from general relativity (GR) may change the geometry and orientation of artificial earth satellite orbits, i.e., the Schwarzschild, Lense–Thirring, and De Sitter effects. So far, the verification of GR effects was mainly based on the observations of changes in the orientation of satellite orbital planes. We directly observe changes of the satellite orbit geometry caused by GR represented by the semimajor axis and eccentricity. We measure the variations of orbit size and shape of GPS, GLONASS, and Galileo satellites in circular and eccentric orbits and compare the results to the theoretical effects using three years of real GNSS data. We derive a solution that assumes the GR to be true, and a second solution, in which the post-Newtonian parameters are estimated, thus, allowing satellites to find their best spacetime curvature. For eccentric Galileo, GR changes the orbital shape and size in perigee in such a way that the orbit becomes smaller but more circular. In the apogee, the semimajor axis decreases but eccentricity increases, and thus, the orbit becomes more eccentric. Hence, the orbital size variabilities for eccentric orbits are greatly compensated by the orbital shape changes, and thus the total effect of satellite height change is much smaller than the effects for the size and shape of the orbit, individually. The mean semimajor axis offset based on all GPS, GLONASS, and Galileo satellites is − 17.41 ± 2.90 mm, which gives a relative error of 0.36% with respect to the theoretical value.
Seat assignment problem with the payable up-grade as an ancillary service of airlines
Authors: Yoon Moongil , Lee Habin 
Published: October 2021

AbstractThe de-bundling and re-bundling of service products offered by low cost carriers from service innovation have become 'à-la-carte' services and chargeable ancillary services to generate additional revenues in the airline industry. In this paper, we focus on the payable upgrade option in airlines to increase revenue when customers' demands are uncertain. This study is as an extension of planned upgrade, which guarantees the use of low-quality services at a low price, but requires customers to pay to use upgraded benefits. In this paper, we focus on the seat assignment problem with the payable upgrade option to maximize revenue. Also, we set the condition under which payable upgrade options can generate more revenue. Furthermore, applying Belobaba's EMSR approach, we suggest an effective seat assignment method for multiple fare classes with a payable upgrade option to increase the total revenue. With a simple numerical example, we find that introducing a payable upgrade option can increase the revenue. Our method for allocating seats for multiple fare classes with a payable upgrade option can contribute effectively to revenue increases in airlines' branded fare products, as well as in other service industries.
Spatial concentration of creative industries and location of creative clusters in Poland
Authors: Namyślak Beata , Spallek Waldemar 
Published: October 2021

AbstractThe authors compared the geographical distribution of creative clusters in Poland with the spatial distribution of LQ (Location Quotient) measuring the concentration of creative entities in a given area. The study aimed to answer the following questions: what is the spatial distribution of clustering potential for creative industries?, which municipalities are home to entities forming creative clusters?, and, above all, are creative clusters actually formed in areas offering the greatest potential in this respect? In order to find answers to the above questions, the authors carried out two sub-analyses. The first led to the conclusion that only 1.9% of municipalities in Poland offer conditions for creative specialisations, including the formation of creative clusters (LQ > 1.25). The next step involved a comparison of geographical distribution of areas with clustering potential with areas being home to actual creative clusters. The authors did not observe any relationship between the value of LQ reflecting clustering potential for creative industries and the distribution and size of active creative clusters. The correlation coefficient between LQ and the number of cluster members was positive but weak. It shows that creative clusters in Poland are not formed in locations offering best conditions in terms of the number of potential members. Therefore, there are other factors behind the formation of cluster structures. Nevertheless, local potential should be the main driving force because it is one of the crucial components of favourable conditions for building economic specialisation and a foundation on which proper cluster structures should be built on.
Identification S100A9 as a potential biomarker in neuroblastoma
Authors: Chen Xian , Xue Yukun , Feng Jiao , Tian Qingwu , Zhang Yunyuan , Wang Qing 
Published: October 2021

Abstract
Background
More than half of Neuroblastoma (NB) patients presented with distant metastases and the relapse of metastatic patients was up to 90%. It is urgent to explore a biomarker that could facilitate the prediction of metastasis in NB patients.

Methods and results
In the present study, we systematically analyzed Gene Expression Omnibus datasets and focused on identifying the critical molecular networks and novel key hub genes implicated in NB metastasis. In total, 176 up-regulated and 19 down-regulated differentially expressed genes (DEGs) were identified. Based on these DEGs, a PPI network composed of 150 nodes and 452 interactions was established. Through PPI network identification combined with qRT-PCR, ELISA and IHC, S100A9 was screened as an outstanding gene. Furthermore, in vitro tumorigenesis assays demonstrated that S100A9 overexpression enhanced the proliferation, migration and invasion of NB cells.

Conclusions
Taken together, our findings suggested that S100A9 could participate in NB tumorigenesis and progression. In addition, S100A9 has the potential to be used as a promising clinical biomarker in the prediction of NB metastasis.
Software review: The JATSdecoder package—extract metadata, abstract and sectioned text from NISO-JATS coded XML documents; Insights to PubMed central’s open access database
Authors: Böschen Ingmar 
Published: October 2021

AbstractJATSdecoderis a general toolbox which facilitates text extraction and analytical tasks on NISO-JATS coded XML documents. Its functionJATSdecoder()outputs metadata, the abstract, the sectioned text and reference list as easy selectable elements. One of the biggest repositories for open access full texts covering biology and the medical and health sciences is PubMed Central (PMC), with more than 3.2 million files. This report provides an overview of the PMC document collection processed withJATSdecoder(). The development of extracted tags is displayed for the full corpus over time and in greater detail for some meta tags. Possibilities and limitations for text miners working with scientific literature are outlined. The NISO-JATS-tags are used quite consistently nowadays and allow a reliable extraction of metadata and text elements. International collaborations are more present than ever. There are obvious errors in the date stamps of some documents. Only about half of all articles from 2020 contain at least one author listed with an author identification code. Since many authors share the same name, the identification of person-related content is problematic, especially for authors with Asian names.JATSdecoder()reliably extracts key metadata and text elements from NISO-JATS coded XML files. When combined with the rich, publicly available content within PMCs database, new monitoring and text mining approaches can be carried out easily. Any selection of article subsets should be carefully performed with in- and exclusion criteria on several NISO-JATS tags, as both the subject and keyword tags are used quite inconsistently.
Citation analysis of Ph.D. theses with data from Scopus and Google Books
Authors: Donner Paul 
Published: October 2021

AbstractThis study investigates the potential of citation analysis of Ph.D. theses to obtain valid and useful early career performance indicators at the level of university departments. For German theses from 1996 to 2018 the suitability of citation data from Scopus and Google Books is studied and found to be sufficient to obtain quantitative estimates of early career researchers’ performance at departmental level in terms of scientific recognition and use of their dissertations as reflected in citations. Scopus and Google Books citations complement each other and have little overlap. Individual theses’ citation counts are much higher for those awarded a dissertation award than others. Departmental level estimates of citation impact agree reasonably well with panel committee peer review ratings of early career researcher support.