bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brownian Motion at the Speed of Light: A New Lorentz Invariant Family of Processes
Authors: Serva Maurizio 
Published: March 2021

AbstractWe consider here a new family of processes which describe particles which only can move at the speed of light c in the ordinary 3D physical space. The velocity, which randomly changes direction, can be represented as a point on the surface of a sphere of radius c and its trajectories only may connect points of this variety. A process can be constructed both by considering jumps from one point to another (velocity changes discontinuously) and by continuous velocity trajectories on the surface. We recently proposed to follow this second strategy assuming that the velocity is described by a Wiener process (which is isotropic only in the ’rest frame’) on the surface of the sphere. Using both Ito calculus and Lorentz boost rules, we succeed here in characterizing the entire Lorentz-invariant family of processes. Moreover, we highlight and describe the short-term ballistic behavior versus the long-term diffusive behavior of the particles in the 3D physical space.
Path planning for endovascular catheterization under curvature constraints via two-phase searching approach
Authors: Li Zhen , Dankelman Jenny , De Momi Elena 
Published: March 2021

Abstract

Purpose

Planning a safe path for flexible catheters is one of the major challenges of endovascular catheterization. State-of-the-art methods rarely consider the catheter curvature constraint and reduced computational time of path planning which guarantees the possibility to re-plan the path during the actual operation.

Methods

In this manuscript, we propose a fast two-phase path planning approach under the robot curvature constraint. Firstly, the vascular structure is extracted and represented by vascular centerlines and corresponding vascular radii. Then, the path is searched along the vascular centerline using breadth first search (BFS) strategy and locally optimized via the genetic algorithm (GA) to satisfy the robot curvature constraint. This approach (BFS-GA) is able to respect the robot curvature constraint while keeping it close to the centerlines as much as possible. We can also reduce the optimization search space and perform parallel optimization to shorten the computational time.

Results

We demonstrate the method’s high efficiency in two-dimensional and three-dimensional space scenarios. The results showed the planner’s ability to satisfy the robot curvature constraint while keeping low computational time cost compared with sampling-based methods. Path replanning in femoral arteries can reach an updating frequency at $$6.4\pm 2.3$$

6.4
±
2.3

Hz.

Conclusion

The presented work is suited for surgical procedures demanding satisfying curvature constraints while optimizing specified criteria. It is also applicable for curvature constrained robots in narrow passages.
Psychological Aspects to Consider in Breast Cancer Diagnosis and Treatment
Authors: Dinapoli Loredana , Colloca Giuseppe , Di Capua Beatrice , Valentini Vincenzo 
Published: March 2021

Abstract
Purpose of Review
Breast cancer (BC) is the most common cancer diagnosed in women in the West World. Coping with cancer is cause of extreme stress for patients and their family. The purpose of this review is to evaluate possible approaches to follow to control those situations that can impact on quality of life (QoL) and compliance to treatments.

Recent Findings
Anxiety, distress, depression, and posttraumatic stress disorder are the most frequent psychological disorders in BC patients. Cognitive disorders and sexual dysfunction can also be important in affecting QoL both in younger and older patients. Younger and older patients show different characteristics of these disorders and different strategies of managing them.

Summary
Several psychotherapeutic and supportive approaches have proven effective in managing psychological disorders in BC patients. Every BC patient should be supported with these techniques during her entire oncological history, in order to increase QoL and compliance to treatments.
Native and IgE-primed rat peritoneal mast cells exert pro-inflammatory activity and migrate in response to yeast zymosan upon Dectin-1 engagement
Authors: Żelechowska Paulina , Brzezińska-Błaszczyk Ewa , Różalska Sylwia , Agier Justyna , Kozłowska Elżbieta 
Published: March 2021

AbstractMast cells (MCs) play an essential role in host defense, primarily because of their location, their ability to pathogen destruction via several mechanisms, and the pattern recognition receptors they express. Even though most data is available regarding MC activation by various bacteria- or virus-derived molecules, those cells’ activity in response to constituents associated with fungi is not recognized enough. Our research aimed to address whether Saccharomyces cerevisiae-derived zymosan, i.e., β-(1,3)-glucan containing mannan particles, impacts MC activity aspects. Overall, the obtained results indicate that zymosan has the potential to elicit a pro-inflammatory response of rat peritoneal MCs. For the first time ever, we provided evidence that zymosan induces fully mature MC migration, even in the absence of extracellular matrix (ECM) proteins. Moreover, the zymosan-induced migratory response of MCs is almost entirely a result of directional migration, i.e., chemotaxis. We found that zymosan stimulates MCs to degranulate and generate lipid mediators (cysLTs), cytokines (IFN-α, IFN-β, IFN-γ, GM-CSF, TNF), and chemokine (CCL2). Zymosan also upregulated mRNA transcripts for several cytokines/chemokines with pro-inflammatory/immunoregulatory activity. Moreover, we documented that zymosan activates MCs to produce reactive oxygen species (ROS). Lastly, we established that the zymosan-induced MC response is mediated through activation of the Dectin-1 receptor. In general, our results strongly support the notion that MCs contribute to innate antifungal immunity and bring us closer to elucidate their role in host-pathogenic fungi interactions. Besides, provided findings on IgE-sensitized MCs appear to indicate that exposure to fungal zymosan could affect the severity of IgE-dependent disorders, including allergic ones.
Population structure of Laurus nobilis L. in Central Italian forests: evidence for its ongoing expansion
Authors: Alessi Nicola , Wellstein Camilla , Spada Francesco , Zerbe Stefan 
Published: March 2021

AbstractDuring the last decades, an ongoing spread of broad-leaved evergreen laurophyllous species has been reported for forests of Southern Europe. Several factors were suggested as the main drivers of the phenomenon, namely global warming, land-use change, evolutionary history, and increase in atmospheric CO2. Among laurophylls, Laurus nobilis L. is considered one of the most prominent from the morphological, evolutionary, and ecological point of view. We studied the population structure of L. nobilis in Central Italy in its natural habitat to investigate its regeneration and potential expansion along with the influence biotic and abiotic factors. To define types of population structures, we collected proportions of six growth classes of L. nobilis in 16 sites. We obtained three types of population structure, i.e., (1) stable, (2) dynamic, and (3) regressive. The first two types are the most frequent, suggesting a potential increase of L. nobilis abundance within forests of Central Italy. The regressive population type occurs mainly in sites with heavy ungulate impact. High propagule pressure along with shaded and moist environmental conditions favor L. nobilis regeneration. Accordingly, we found evidence of a recent L. nobilis spread in Central Italian forests. We suggest the increase of forest cover and age, due to the abandonment of traditional rural practices, as key factors for the regeneration of this apparently late-successional laurophyll. In conclusion, the recent expansion of L. nobilis that we observed in the Italian forest stands can therefore be ascribed to a process of natural recover of a potential niche following land-use change.
Retinae of Anencephalic Fetuses: Quantitative Analysis and Comparison with Fetuses Without any Malformations
Authors: Shah Garima , Dwivedi Daisy , Chander Bal 
Published: March 2021

AbstractAnencephaly is a common congenital malformation characterised by absence of a major portion of the brain. The sequence of brain degeneration starts around 20 days post fertilization which overlaps with the appearance of optic grooves from the forebrain. A number of ocular malformations associated with anencephaly have been reported. Based on the assumption that eyes, which are derived from the brain, are likely to be abnormal since the organ of origin undergoes degeneration, studies have been carried out on anencephalic retinae. Some of the results have indicated that retinae of anencephalic fetuses are abnormal with absence or diminished presence of ganglion cell layer compared to the fetuses without such a brain malformation. We undertook the present study with an aim to objectively and quantitatively evaluate retinal thickness and numbers of ganglion cell in anencephalic fetuses and fetuses without any malformations. Six anencephalic and six fetuses without malformations were included, all of them from 18 to 21 weeks of gestation. Histopathological evaluation of retinae was done and findings compared. We did not find any atrophy or reduced number of ganglion layer cells in anencephalic fetuses. This evaluation assumes importance since retinae from anencephalic fetuses can be a potential source for retinal tissue or stem cell transplant. Moreover, the contention that normal brain development is essential for retinal development appears to be invalid.
A modified NK algorithm based on BP neural network and DEMATEL for evolution path optimization of urban innovation ecosystem
Authors: Liu Ruijian , Tang Fangcheng , Wang Yuhan , Zheng Shaofang 
Published: March 2021

AbstractIn the new era, the key measure to accelerate the construction of smart city, so as to promote the modernization of urban governance system and governance capacity, is to establish a good urban innovation ecosystem, and guide its continuous evolution to the direction of the highest efficiency and the best performance. Focusing on solving the practical problem of “how the urban innovation ecosystem evolves”, this paper develops a NK algorithm using BP neural network and DEMATEL method. First, through literature research, constructing the urban innovation ecosystem including five subsystems of innovation talents, innovation subjects, innovation resources, innovation environment and innovation network. Then, taking Beijing as an example, the weights and the number of epistatic relationships of each subsystem in its innovation ecosystem are calculated by BP neural network and DEMATEL method, and the NK model is modified; on this basis, the fitness values corresponding to different states of the system are calculated using MATLAB software, and the optimal evolution path of Beijing innovation ecosystem is determined through the comparison of 100,000 simulation results. The results show that the optimal evolution path of Beijing's innovation ecosystem is to create a favorable environment and culture for innovation first; then increase the input of innovation resources; and then promote the development of innovation network assets; on this basis, cultivate, attract and retain innovative talents; and finally strengthen the construction of innovation subjects.
inGAP-Family: Accurate Detection of Meiotic Recombination Loci and Causal Mutations by Filtering Out Artificial Variants due to Genome Complexities
Authors: Lian Qichao , Chen Yamao , Chang Fang , Fu Ying , Qi Ji 
Published: March 2021

Abstract
Accurately identifying DNA polymorphisms can bridge the gap between phenotypes and genotypes and is essential for molecular marker assisted genetic studies. Genome complexities, including large-scale structural variations, bring great challenges to bioinformatic analysis for obtaining high-confidence genomic variants, as sequence differences between non-allelic loci of two or more genomes can be misinterpreted as polymorphisms. It is important to correctly filter out artificial variants to avoid false genotyping or estimation of allele frequencies. Here, we present an efficient and effective framework, inGAP-family, to discover, filter, and visualize DNA polymorphisms and structural variants (SVs) from alignment of short reads. Applying this method to polymorphism detection on real datasets shows that elimination of artificial variants greatly facilitates the precise identification of meiotic recombination points as well as causal mutations in mutant genomes or quantitative trait loci. In addition, inGAP-family provides a user-friendly graphical interface for detecting polymorphisms and SVs, further evaluating predicted variants and identifying mutations related to genotypes. It is accessible at https://sourceforge.net/projects/ingap-family/.
Rethinking Research Sites as Wilderness Activity Sites
Authors: Peixotto Becca , Klehm Carla , Eifling Kurt P. 
Published: March 2021

ABSTRACTField research requires careful preparation so as to protect the integrity of archaeological studies and ensure the health and wellness of our students and field crews. In this special issue, we hope to lay a foundation for securing health and wellness as elements of the ethical practice of archaeology fieldwork through discussions of common hazards and tools to prevent, prepare for, and address safety incidents in the field. Even as archaeology and other field sciences grapple with serious safety concerns such as sexual harassment and mental health, it can be tempting to view field sites as extensions of the classroom or office. But field research can be a high-risk endeavor where we are exposed to a range of hazards not typically encountered in a traditional learning or work environment. We reach across disciplinary boundaries toward outdoor leadership and backcountry medicine to introduce the concept of wilderness context to describe the remote—and not-so-remote—locations and conditions common to archaeology field research. These are places where small or unanticipated problems can quickly become serious incidents. By rethinking research sites as wilderness activity sites, we highlight how methodical preparation can help us craft more robust and ethical health and safety practices for all members of our teams.
Ice thickness and volume of the Renland Ice Cap, East Greenland
Authors: Koldtoft Iben , Grinsted Aslak , Vinther Bo M. , Hvidberg Christine S. 
Published: March 2021

Abstract
To assess the amount of ice volume stored in glaciers or ice caps, a method to estimate ice thickness distribution is required for glaciers where no direct observations are available. In this study, we use an existing inverse method to estimate the bedrock topography and ice thickness of the Renland Ice Cap, East Greenland, using satellite-based observations of the surface topography. The inverse approach involves a procedure in which an ice dynamical model is used to build-up an ice cap in steady state with climate forcing from a regional climate model, and the bedrock is iteratively adjusted until the modelled and observed surface topography match. We validate our model results against information from airborne radar data and satellite observed surface velocity, and we find that the inferred ice thickness and thereby the stored total volume of the ice cap is sensitive to the assumed ice softness and basal slipperiness. The best basal model parameters for the Renland Ice Cap are determined and the best estimated total ice volume of 384 km3 is found. The Renland Ice Cap is particularly interesting because of its location at a high elevation plateau and hence assumed low sensitivity to climate change.
Success rate of type 1 tympanoplasty: a comparative study
Authors: Odat H , Alali M , Kanaan Y , Al-Qudah M 
Published: March 2021

AbstractObjectivesThis study aimed to compare graft take rate after tympanoplasty between adults and paediatric patients, cartilage and fascia grafts, and overlay and underlay techniques.MethodsData were analysed in groups according to the technique (underlay vs overlay), age (paediatric patients vs adults) and graft (cartilage vs temporalis fascia). The main outcome measures were full graft take and the incidence of complications.ResultsA total of 198 patients (208 ears) were included. Overall, full graft take was achieved in 200 ears (96 per cent). The success rate was higher in adults compared with paediatric patients (97.5 per cent vs 92.25, respectively) but the difference was insignificant. Similarly, higher but insignificant graft take rate was found in the cartilage group compared with fascia group (98.6 per cent vs 94.9 per cent, respectively).ConclusionAll cases of overlay tympanoplasty had full graft take (success rate 100 per cent). In the underlay group, successful graft take was achieved in 154 cases (95 per cent). This difference was statistically insignificant.
Toxoplasma gondii in mollusks and cold-blooded animals: a systematic review
Authors: Nayeri Tooran , Sarvi Shahabeddin , Daryani Ahmad 
Published: March 2021

AbstractToxoplasma gondii (T. gondii) is known for its ability to infect warm-blooded vertebrates. Although T. gondii does not appear to parasitize cold-blooded animals, the occurrence of T. gondii infection in marine mammals raises concerns that cold-blooded animals (frogs, toad, turtles, crocodiles, snakes, and fish) and shellfish are potential sources of T. gondii. Therefore, this systematic review aimed to determine the prevalence of T. gondii in mollusks and cold-blooded animals worldwide. We searched PubMed, ScienceDirect, ProQuest, Scopus, and Web of Science from inception to 1 August 2020 for eligible papers in the English language and identified 26 articles that reported the prevalence of T. gondii in mollusks and cold-blooded animals. These articles were subsequently reviewed and data extracted using a standard form. In total, 26 studies [involving 9 cross-sectional studies including 2988 samples of cold-blooded animals (129 positive cases for T. gondii) and 18 cross-sectional studies entailing 13 447 samples of shellfish (692 positive cases for T. gondii)] were included in this study. Although this study showed that shellfish and cold-blooded animals could be potential sources of T. gondii for humans and other hosts that feed on them, further investigations are recommended to determine the prevalence of T. gondii in shellfish and cold-blooded animals.
The Relevance of Job-Related Concessions for Unemployment Duration Among Recipients of Means-Tested Benefits in Germany
Authors: CHRISTOPH BERNHARD , LIETZMANN TORSTEN 
Published: March 2021

AbstractUnemployment strongly influences a person’s economic resources and life chances. Especially for unemployed individuals who have to rely on means-tested benefits, episodes of unemployment often go along with substantial material restrictions. Therefore, from a policy perspective, measures or regulations that might shorten unemployment episodes and reduce overall unemployment are particularly important.In this paper, we analyse whether concessions regarding the characteristics of the job searched for influence an individual’s unemployment duration. In doing so, we focus on a particular aspect of availability requirements in Germany. This is the fact that for unemployed recipients of means-tested benefits almost all types of jobs count as suitable employment and, therefore, recipients are obliged to make job-related concessions if offered a job requiring such concessions.The results indicate that there is no positive effect of making concessions regarding qualification requirements or status on employment chances. In contrast, there are positive effects of wage concessions. However, searching for a job in a different occupation (that does not necessarily imply a concession) has a comparable, positive effect on finding employment. Thus, it appears that being generally flexible regarding one’s future occupation might be at least as important for employment chances as making concessions.
Understanding unmet aged care need and care inequalities among older Australians
Authors: Hill Trish 
Published: March 2021

AbstractIn Australia, numerous reviews and inquiries have documented concerns about inadequate access to, and the quality of, aged care. Despite those concerns, research is yet to appraise fully how care needs are assessed, prioritised, and met or left unmet. This paper asks two interrelated questions: (1) How should we conceptualise and measure unmet care need and care inequalities among older people? (2) What are the policy parameters for assessing needs, prioritising access to support and monitoring quality in aged care in Australia? Key insights from academic literature are used to critically review Australian policy documents describing rights, assessments, prioritisation, quality standards and performance indicators for the aged care sector. Using the concepts of care inequalities and care poverty, the paper develops a framework for understanding and measuring needs and unmet needs in aged care, and for encompassing fundamental and valued aspects of life for older people, their carers and their care network. The paper argues that the concept of care poverty opens the space to discuss what level of unmet need and inequality in access to aged care in any society may be considered intolerable.
Lie group based nonlinear state errors for MEMS-IMU/GNSS/magnetometer integrated navigation
Authors: Cui Jiarui , Wang Maosong , Wu Wenqi , He Xiaofeng 
Published: March 2021

AbstractIn the integrated navigation system using extended Kalman filter (EKF), the state error conventionally uses linear approximation to tackle the commonly nonlinear problem. However, this error definition can diverge the filter in some adverse situations due to significant distortion of the linear approximation. By contrast, the nonlinear state error defined in the Lie group satisfies the autonomous equation, which thus has distinctively better convergence property. This work proposes a novel strapdown inertial navigation system (SINS) nonlinear state error defined in the Lie group and derives the SINS equations of the Lie group EKF (LG-EKF) for the MIMU/GNSS/magnetometer integrated navigation system. The corresponding measurement equations are also derived. A land vehicle field test has been conducted to evaluate the performance of EKF, ST-EKF (state transformation extended Kalman filter) and LG-EKF, which verifies LG-EKF's superior estimation accuracy of the heading angle as well as the other two horizontal angles (pitch and roll). The LG-EKF proposed in this paper is unlimited in the choice of sensors, which means it can be applied with both high-end and low-end inertial sensors.
Expression of anaphoric subjects in Vera'a: Functional and structural factors in the choice between pronoun and zero
Authors: Schnell Stefan , Barth Danielle 
Published: March 2021

AbstractThe choice between a pronoun and zero anaphor for the expression of third-person subjects is examined in a corpus of Vera'a (Oceanic). While predominantly expressed by a pronoun, subjects are found to permit zero form with referents that have low anaphoric distance. Within this context, zero is found to be preferred with a subset of verbal predicates that take a specific tense-aspect-mood-polarity (TAMP) marker that historically retains subject agreement. The strong preference for pronouns is related to the clitic behavior of adjacent TAMP morphology and the rudimentarity of agreement. Animacy and number also bear on subject variation. Effects of clause-combining and the use of connectives do not align with findings from studies of the same choice in other languages. Our findings underscore the prominent role of purely structural over functional motivations for the choice of pronouns over zero.