bluuebunny/crossref_metadata_2025_split huggingface dataset:
The psychometric properties of the Bidimensional Acculturation Scale for Marriage-Based Immigrant Women in Taiwan
Authors: Chen Hung-Hui , Lai Jerry Cheng-Yen , Chien Li-Yin 
Published: October 2021

Introduction
Marriage-based immigrant women are increasing around the world. Although bi-dimensional acculturation is important for immigrant women’s health, the existing scales have mainly been developed for immigrant women in Western countries and hence some items may not be suitable for Asian contexts. Thus, we developed and evaluated the Bidimensional Acculturation Scale for Marriage-Based Immigrant Women (BAS-MBIW) in Taiwan.

Methods
The BAS-MBIW was developed based on a literature review and clinical observations. Bi-dimensional acculturation involves “adaptation to host culture (acculturation)” and “maintenance of heritage culture (enculturation).” The initial scale included two 24-item subscales. The validation samples were 310 marriage-based immigrant women who were pregnant for at least twelve weeks in Taiwan. The BAS-MBIW was assessed and modified by experts. Data analyses included factor analysis, Pearson’s correlation, and Cronbach’s alpha coefficient.

Results
Expert reviews and factor analysis indicated that the scale had acceptable content and construct validity. The validated scale includes two 19-item subscales, encompassing six domains: language, media, food preference, cultural heritage, social interaction, and shopping and merchandise preference, with good internal consistencies (Cronbach’s alpha coefficient is 0.88 for acculturation and 0.83 for enculturation). Acculturation was positively related to local language ability and duration of immigration but negatively related to age at immigration, stress, and depression; whereas enculturation was positively related to age at immigration, stress, and depression but negatively related to duration of immigration, indicating convergent validity.

Conclusions
The BAS-MBIW offers reliable and valid assessments of pregnant immigrant women’s level of acculturation and enculturation in Taiwan. The BAS-MBIW could be used to assess bi-dimensional acculturation among marriage-based immigrant women.
The real-world outcomes of multiple myeloma patients treated with daratumumab
Authors: Szabo Agoston Gyula , Klausen Tobias Wirenfeldt , Levring Mette Bøegh , Preiss Birgitte , Helleberg Carsten , Breinholt Marie Fredslund , Hermansen Emil , Gjerdrum Lise Mette Rahbek , Bønløkke Søren Thorgaard , Nielsen Katrine , Kjeldsen Eigil , Iversen Katrine Fladeland , Teodorescu Elena Manuela , Dokhi Marveh , Kurt Eva , Strandholdt Casper , Andersen Mette Klarskov , Vangsted Annette Juul 
Published: October 2021

Most patients cannot be included in randomized clinical trials. We report real-world outcomes of all Danish patients with multiple myeloma (MM) treated with daratumumab-based regimens until 1 January 2019.

Methods
Information of 635 patients treated with daratumumab was collected retrospectively and included lines of therapy (LOT), hematologic responses according to the International Myeloma Working Group recommendations, time to next treatment (TNT) and the cause of discontinuation of treatment. Baseline characteristics were acquired from the validated Danish Multiple Myeloma Registry (DMMR).

Results
Daratumumab was administrated as monotherapy (Da-mono) in 27.7%, in combination with immunomodulatory drugs (Da-IMiD) in 57.3%, in combination with proteasome inhibitors (Da-PI) in 11.2% and in other combinations (Da-other) in 3.8% of patients. The median number of lines of therapy given before daratumumab was 5 for Da-mono, 3 for Da-IMiD, 4 for Da-PI, and 2 for Da-other. In Da-mono, overall response rate (ORR) was 44.9% and median time to next treatment (mTNT) was 4.9 months. In Da-IMiD, ORR was 80.5%, and mTNT was 16.1 months. In Da-PI, OOR was 60.6% and mTNT was 5.3 months. In patients treated with Da-other, OOR was 54,2% and mTNT was 5.6 months. The use of daratumumab in early LOT was associated with longer TNT (p<0.0001). Patients with amplification 1q had outcome comparable to standard risk patients, while patients with t(4;14), t(14;16) or del17p had worse outcome (p = 0.0001). Multivariate analysis indicated that timing of treatment (timing of daratumumab in the sequence of all LOT that the patients received throughout the course of their disease) was the most important factor for outcome (p<0.0001).

Conclusion
The real-world outcomes of multiple myeloma patients treated with daratumumab are worse than the results of clinical trials. Outcomes achieved with daratumumab were best when daratumumab was used in combination with IMIDs and in early LOT. Patients with high-risk CA had worse outcomes, but patients with amp1q had similar outcomes to standard-risk patients.
The effects of a physical and cognitive training intervention vs. physical training alone on older adults’ physical activity: A randomized controlled trial with extended follow-up during COVID-19
Authors: Savikangas Tiina , Törmäkangas Timo , Tirkkonen Anna , Alen Markku , Fielding Roger A. , Kivipelto Miia , Rantalainen Timo , Stigsdotter Neely Anna , Sipilä Sarianna 
Published: October 2021

BackgroundExecutive functions underlie self-regulation and are thus important for physical activity and adaptation to new situations. The aim was to investigate, if yearlong physical and cognitive training (PTCT) had greater effects on physical activity among older adults than physical training (PT) alone, and if executive functions predicted physical activity at baseline, after six (6m) and twelve months (12m) of the interventions, one-year post-intervention follow-up and an extended follow-up during COVID-19 lockdown.MethodsData from a single-blinded, parallel-group randomized controlled trial (PASSWORD-study, ISRCTN52388040) were utilized. Participants were 70–85 years old community-dwelling men and women from Jyväskylä, Finland. PT (n = 159) included supervised resistance, walking and balance training, home-exercises and self-administered moderate activity. PTCT (n = 155) included PT and cognitive training targeting executive functions on a computer program. Physical activity was assessed with a one-item, seven-scale question. Executive functions were assessed with color-word Stroop, Trail Making Test (TMT) B-A and Letter Fluency. Changes in physical activity were modeled with multinomial logistic models and the impact of executive functions on physical activity with latent change score models.ResultsNo significant group-by-time interaction was observed for physical activity (p>0.1). The subjects were likely to select an activity category higher than baseline throughout the study (pooled data: B = 0.720–1.614, p<0.001–0.046). Higher baseline Stroop predicted higher physical activity through all subsequent time-points (pooled data: B = 0.011–0.013, p = 0.015–0.030). Higher baseline TMT B–A predicted higher physical activity at 6m (pooled data: B = 0.007, p = 0.006) and during COVID-19 (B = 0.005, p = 0.030). In the PT group, higher baseline Letter Fluency predicted higher physical activity at 12m (B = -0.028, p = 0.030) and follow-up (B = -0.042, p = 0.002).ConclusionsCognitive training did not have additive effects over physical training alone on physical activity, but multicomponent training and higher executive function at baseline may support adaptation to and maintenance of a physically active lifestyle among older adults.
Riddance jamming of pipeline shut-off valves
Authors: Bazarov Alexander A. , Bondareva Nataliya V. , Navardyan Ashot A. 
Published: October 2021

The paper conciders the problems of modeling the processes of thermal deformation of valves with an ambient temperature decrease. Some type of wedge valves are exposed to jamming. Heating the valve body is used to eliminate jamming. This problem is common for rigid wedge valves but the reasons not fully explained. Sometimes the valve stem is destroyed due to the significant power of the gate valve electric drives. The aim of the study is to determine the nature of the stress distribution between the structural elements of the valve, which are the cause of jamming with an ambient temperature decrease, and to search for the parameters of the heating process that ensure minimum energy consumption and time.
To study the thermal processes in the valve body, a numerical model describing the heat transfer in the structural elements and the fluid is developed. The thermal model is combined with the elastic deformation model. That allows to make compatible calculations without introducing additional errors. The thermal deformations appear in the cooling process and give rise to disproportionate changes in valve dimensions and thermal stresses. Thermal stresses are the cause of jamming. Modeling of the processes of thermal deformation with a decrease in temperature showed that pressure forces of different signs arise in the middle plane of the wedge. At the average height of the horizontal line, there is a compacting pressure and at the lower and upper points there is a stretching pressure. To eliminate the compacting forces local heating was performed in several areas of the body. It was found that the most effective option is to heat the lower hemispherical surface of the body. Heating for thirty minutes reduces the thermal stresses in the wedge and compressive forces to minimum values. For this reason, jamming of the valve is eliminated. For heating the body, a hemispherical induction heater with a magnetic core is provided. The proposed design allows the use of industrial frequency voltage without a step-down transformer and reactive power compensation.
Hydrogel networks by aliphatic dithiol Michael addition to glycidylmethacrylated gelatin
Authors: Neffe Axel T. , Löwenberg Candy , Lendlein Andreas 
Published: October 2021

AbstractFunctionalization of gelatin with glycidylmethacrylate (GMA-gelatin) enables network formation employing the double bond, so that the reaction is orthogonal to the inherent functional groups in the biomacromolecule. Here, network formation by crosslinking of GMA-gelatin with hexane 1,6-dithiol or nonane 1,9-dithiol to tailor properties and enable a shape-memory effect is shown by 1H NMR and FT-IR spectroscopy. Hydrogel swelling (460–1900 vol%) and mechanical properties (Young’s modulus E = 59–512 kPa, elongation at break εb = 44–127%) depended on the molecular composition of the networks and temperature. Increased crosslinker length, thiol:methacrylate molar ratio, and precursor concentrations led to denser networks. Change of properties with temperature suggested adoption of triple helices by gelatin chains, forming physical netpoints at lower temperatures (< 20 °C). However, the limited freedom of the gelatin chains to move allowed only a minimal extent of triple helices formation, as it became apparent from the related signal in wide-angle X-ray scattering and the thermal transition associated to triple helices in some networks by DSC. The presented strategy is likely transferable to other biomacromolecules, and the results suggest that too short crosslinkers may result in a significant amount of grafting rather than network formation.
Graphic abstract
Markers of atherosclerosis lipoprotein-associated phospholipase A2 and E-selectin and vascular risk factors in patients with carotid stenosis
Authors: Dubenko Olga , Anysienkova Victoria 
Published: October 2021

The aim of this study is to evaluate serum level biomarkers of atherosclerosis lipoprotein-associated phospholipase A2 and E-selectin in patients with atherosclerotic carotid stenosis with different clinical manifestation in associated with vascular risk factors.
Materials and methods: A total 106 patients with atherosclerotic carotid stenosis (74 men and 32 women, aged from 31 to 74 years, mean 62.6±0.9) were included: with acute ipsilateral atherothrombotic stroke (35), history of stroke and carotid endarterectomy (41) and 30 patients with asymptomatic carotid stenosis. The control group consist of 20 health subjects without cardiovascular disease. All participants underwent duplex sonography. Lipoprotein-associated phospholipase A2 and E-selectin was measured using commercially available (ELISA) kit.
Results: The level of lipoprotein-associated phospholipase A2 was in general 55.664±3.537 ng/ml, which was significantly higher (M-W U=10, p=1.023136´10-11 <0.05) than in the control group (9.296±0.935 ng/ml). Level was significantly higher in groups of symptomatic patients who underwent carotid endarterectomy (p=0.04893), and proportion patients with high degree stenosis >70 % was greater in this group. The level of E-selectin in the study patients was significantly higher (7.653±0.246 pg/ml) than in the control group (3.101±0.503 pg/ml) p<0.05. No association the serum level of lipoprotein-associated phospholipase A2 and E-selectin with common stroke risk factor such as hypercholesterinemia, smoking and body mass index were found, but positive correlation of lipoprotein-associated phospholipase A2 with E-selectin was significant (p=0.00085).
Conclusions: Increasing plasma level lipoprotein-associated phospholipase A2 and E-selectin in patients with the carotid atherosclerotic stenosis were observe. Statistically significant correlation between the level of lipoprotein-associated phospholipase A2 and E-selectin were found in symptomatic carotid atherosclerotic stenosis
Morphological and anatomical properties of Veronica crista-galli Steven
Authors: Pashayeva Nigar Hidayet , Suleymanov Tahir Abbasali , Kerimov Yusif Balakerim , Gasimov Eldar Kocheri , Rzayev Fuad Huseynali 
Published: October 2021

The aim of this work was to study of diagnostic signs of the morphological and anatomical structure of Veronica crista-galli Steven. from the flora of Azerbaijan.
Materials and methods. The samples for research were collected during their flowering time in June 2018, in the Ismailli region of the Republic of Azerbaijan. Plant samples were fixed in a solution made in 0.1 M phosphate buffer (pH=7.4), containing 2.5 % glutar-aldehyde, 2.5 % paraformal-aldehyde and 0.1 % picric acid. In the next stage was the preparation of block and their filling in Araldite – Epon according to the TEM method.
Results. The leaf is simple, lower part is short-petiolate and upper is sessile. The surface, on both sides of the leaf, is reliefly, and 7–8 conductive veins are clearly visible. The lower and upper sides of the leaf, and also margin, are strewn with multicellular hairs. The calyx of the flower consists of two sepals which grown together at the base, covered with simple multicellular hairs. The stalk in is a long filiform. The corolla of flower consists of 4 petals which grown together at the base and 2 stamens attached to the tube of the corolla. On the epidermis, cells with sinuous and bead-like walls, numerous stomata of the stavrocytic type, capitate hairs are visible. From the cross section of the leaf, it is visible that palisade tissue at the upper and sponge tissue at the bottom.
Conclusions. As a result of morphological and anatomical studies, it was revealed that diagnostic signs of plant raw material can be: Present of multicellular hairs on the leaf blade; The location of the capsule between the sepals; Stavrocytic type of the stoma structure; The bead-like walls of the epidermis; Capitate hairs on the epidermis; Sepals covered by hairs.
The established anatomical diagnostic features can be used for the drafting of the normative document on the plant raw materials and for identification of plant raw material of Veronica crista-galli
AUTOMATIC DETERMINATION OF THE NAVIGATORS MOTIVATION MODEL WHEN OPERATING WATER TRANSPORT
Authors: Nosov P. S. , Popovych I. S. , Zinchenko S. M. , Kobets V. M. , Safonova A. F. , Appazov E. S. 
Published: October 2021

Context. The article proposes an approach for automated identification of the navigators motivational model in the control of water transport. Algorithms for data extraction as a result of the man-machine interaction of navigator with the electronic control systems of the vessel during performing navigation operations of increased complexity are proposed.
Objective. The purpose of research is to apply formal and algorithmic approaches to extracting data on the motivational model of navigator to prevent accidents in water transport.
Method. The identification of manifestation determination of navigators’ mental activity by means of the visual concept of the geometric group theory is proposed. This approach delivered the visual systematic-logical combining of diagnostic methods aimed at determining navigators motivational centers and the processes of professional activity like maneuver performing. The key indicator of identification is said to be the parameter of the navigator’s activity as “rpm_port” having an impact on the vessel speed being a marker of intensification of the navigator’s physiological activity. Such an approach is beneficial in time phase identification while maneuvering indicating explicitly at the stepping up of the navigator’s physiological motivational state. It was proven to be correct based on the results due to Ward’s dendrogram, several statistical methods and applied software. The obtained research results encourage the prediction of the navigator’ motivational states in critical situations.
Results. In order to confirm the proposed formal-algorithmic approach, an experiment was carried out using the navigation simulator Navi Trainer 5000. Automated analysis of experimental ones made it possible to form a motivational map of the navigator and determine the decision-making model affecting in the processes of control vessel in difficult situations.
Conclusions. The proposed research approaches made it possible to automate the processes of extracting data indicating the principles of decision-making by navigator. The effectiveness of proposed approach was substantiated by the results of experimental data automated processing and the constructed tree-like decision-making spaces.
MULTI-AGENT LATENT SEMANTIC INTERNET TECHNOLOGY FOR THE FORMATION OF A SUBJECT-ORIENTED KNOWLEDGE MODEL
Authors: Stenin A. A. , Pasko V. P. , Soldatova M. A. , Drozdovich I. G. 
Published: October 2021

Context. The article proposes a latent-semantic technology for extracting information from Internet resources, which allows processing information in natural language, as well as a multi-agent search algorithm based on it. The relevance of this approach to the search for subject-oriented information determined by the fact that currently a direct lexical comparison of queries with document indexes does not fully satisfy the developer. The object of the study is a multi-agent latent-semantic algorithm for searching for subject-oriented information.
Objective. The work is to increase the efficiency of forming a knowledge model that is adequate for this subject area.
Method. A latent semantic technology based on the weighted descriptor method developed by the authors is proposed. The main difference from the existing methods is that the analysis of words occurring in the text both in frequency and taking into account semantics carried out by selecting the appropriate descriptors, which improves the quality of the information found.
Results. The developed latent-semantic technology of information search tested in the task of constructing a knowledge model of automated decision support systems for operational and dispatching control of urban engineering networks. The conducted modeling of the search for subject-oriented information in this subject area showed the effectiveness of the developed approach.
Conclusions. Improving the efficiency of search and semantic content of subject-oriented information of the knowledge model of this subject area achieved by using the weighted descriptor method based on Zipf’s laws in this technology. The prospects for further research are to build evolutionary models of knowledge and improve the quality of updated information.
Materials based o tricalcium phosphate as bone defects substitute (literature review)
Authors: Korzh Mykola , Filipenko Volodymyr , Poplavska Karolina , Ashukina Nataliya 
Published: October 2021

The objective of the study is to determine the current tendencies in the use of osteoplastic materials based on tricalcium phosphate (TCP) in orthopedics and traumatology. Methods. The search of the scientific information for the analysis was carried out in the PubMed, Google Scholar, World Digital Library, ScienceDirect. Results. The development of biomaterials for reconstructive surgery on the skeleton remains an urgent issue of biomaterial engineering, biology and current traumatology and orthopedics. Calcium-phosphate ceramics have the excellent properties of biocompatibility, affinity with bone tissue, biodegradability as well as perfect osteoconductive and osteointegrative properties. They are used in orthopaedics and traumatology as a coating for endoprosthesis components in order to achieve a strong bond with the bone as well as a filling material for bone defects in the form of blocks, granules or powder. The optimal structure of ceramic materials in order to achieve the necessary hardness and control of the dissolution rate is still undetermined. The interest of researchers in the creation of osteoplastic materials containing TCP is explained by the advanced osteoinductive properties and the ability to quickly degrade with the formation of bone tissue. Due to different configurations and sizes of the bone defects, the creation of a material with osteoinductive and osteoconductive properties that could be inserted into the cavity in a liquid state and which would quickly harden and acquire the properties similar to those of the bone has been of great current interest. The material should be biodegradable while having sufficient time for bone formation at the implantation site. In view of the above, the creation of cements based on calcium phosphates has become more attractive. Unfortunately, this material is limited in use due to its brittleness and insufficient hardness. Certain reinforcing additives are expected to significantly improve the mechanical properties of the cement. It is desirable that these particles should have bioactive properties analogous to those of cement. A slight modification of the material can significantly change its properties, which makes it imperative to investigate experimentally the biological properties of the investigated material.