bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracing the Ritarian Roots: Talangpaz Sisters and Augustinian Recollects of San Sebastian Church
Authors: Romanillos Prof. Emmanuel Luis A. 
Published: February 2021

This historical account retraces the roots of Saint Rita College that commenced its foundation totally unheralded in 1907. In the horizon, we find the foundresses of the Congregation of the Augustinian Recollect Sisters: Mother Dionisia de Santa María, Mother Cecilia Rosa de Jesús and the Augustinian Recollects of the San Sebastian Church in Manila. The two foundresses were blood sisters who left their hometown in 1719 and traveled to San Sebastian de Calumpang in Manila where the cherished icon of Our Lady of Mount Carmel. They found a small house in Bilibid Viejo where they lived a life of seclusion, contemplation, and mortification. Their virtue and piety attracted the Augustinian Recollects of San Sebastian Convent. Not long after the Beaterio de San Sebastian was founded. It was 16 July 1725 when they lived as terciarias and followed the Rule of Saint Augustine under the protection of the Recollect religious of San Sebastian Convent. In 1907, the Recollect Fathers urged the sisters of the Beaterio to open a school for girls, after defraying the construction of the new edifice. And the Beaterio came in into being in 1907 Saint Rita Academy, later Colegio de Santa Rita, or Saint Rita College.
Impact of Sexual Jealousy on Partner Infidelity among University Students: Gender as Moderator
Authors: Saleem Dr Muhammad , Nazeer Amna , Durrani Areeha Khan 
Published: February 2021

This research was aimed to examine the moderating role of gender on the impact of sexual jealousy on partner infidelity among university students. For the purpose, a sample of 352 students were recruited through simple random sampling technique from four cities (Bahawalpur, Multan, Lahore, Rawalpindi) of Punjab, Pakistan. Respondents were given two questionnaires; Interpersonal Jealousy Scale and Infidelity Questionnaire. After data collection, results were analysed through SmartPLS (3.0) for moderation model. The results showed that sexual jealousy had significant positive impact showing 59% variance on partner infidelity, whereas, gender was found to be a significant moderator between sexual jealousy and partner infidelity (R2= 0.594, t= 2.403, p<.01). The results of this research are discussed in detail with limitations and future suggestions for the future researches related to impact of sexual jealousy on partner infidelity.
UPAYA PENINGKATAN HASIL BELAJAR SISWA KONSEP SHOOTING BOLA BASKET MELALUI MODIFIKASI SARANA PEMBELAJARAN
Authors: Syahnuar Syahnuar 
Published: February 2021

Olahraga bola basket yang dimodifikasi akan mampu mengembangkan keterampilan anak lebih cepat dibanding dengan peralatan standar untuk orang dewasa karena tidak terhalang oleh peralatan yang terlalu berat dan lapangan yang tidak terlalu luas. Selanjutnya olahraga yang dimodifikasi dapat menumbuhkan kegembiraan dan kesenangan pada anak-anak dalam situasi kompetitif dengan memodifikasi sarana pembelajaran. Penggunaan alat bantu sebagai modifikasi sarana pembelajaran bola basket menjadi alternatif yang dapat digunakan oleh guru untuk memancing perhatian siswa dalam pembelajaran. Subjek penelitian ini adalah siswa kelas IXA SMPN 1 Muaro Jambi kabupaten Muaro Jambi. Sebelum pelaksanaan tindakan, siswa yang berhasil mencapai batas ketuntasan nilai minimal pada angka 75 untuk hasil belajar shooting bola basket sebanyak 5 siswa dari 26 siswa atau sekitar 19,23%. Setelah dilakukan tindakan terjadi peningkatan hasil belajar shooting bola basket menjadi 96,2% atau sekitar 25 siswa. Sehingga peningkatan kualitas berupa proses pembelajaran pada kemampuan melakukan gerak dasar shooting bola basket. Jadi modifikasi sarana pembelajaran shooting bola basket telah berhasil meningkatkan hasil belajar siswa.
Pulmonary embolism in pregnancy with COVID‐19 infection: A case report
Authors: Goudarzi Sogand , Firouzabadi Fatemeh Dehghani , Mahmoudzadeh Fatemeh , Aminimoghaddam Soheila 
Published: February 2021

AbstractPregnant women in the third trimester are at the highest risk. Contracting COVID‐19 increases the complications. Hence, it is critical for pregnant women, especially during the third trimester, with slightest COVID‐19 symptoms to visit as soon as possible. Early diagnosis considerably contributes to saving both the mother and the fetus.
Preparation of Peptide Selenoesters from Their Corresponding Acyl Hydrazides†
Authors: Li Yunxue , Liu Jiazhi , Zhou Qingqing , Zhao Jie , Wang Ping 
Published: February 2021

Main observation and conclusionSelenoesters are useful substitutes for traditional thioesters in protein ligation chemistry due to their high reactivity in the trans‐thio/selenoesterification reaction. However, existing synthetic routes to access peptide selenoester require a selenoesterification reaction between a selenide and a protected peptide with a free carboxylate at the C‐terminus. Herein, we introduce an efficient method to convert peptide acyl hydrazide, a convenient thioester surrogate, into the desired selenoester for peptide ligation. Our methodology can be applied to fully de‐protected peptides with various C‐terminal amino acid residues in high yield without racemization. We believe that this method provides a useful alternative to access peptide C‐terminal selenoesters for protein ligation.
Structural characterization of the self‐association domain of swallow
Authors: Loening Nikolaus M. , Barbar Elisar 
Published: February 2021

AbstractSwallow, a 62 kDa multidomain protein, is required for the proper localization of several mRNAs involved in the development of Drosophila oocytes. The dimerization of Swallow depends on a 71‐residue self‐association domain in the center of the protein sequence, and is significantly stabilized by a binding interaction with dynein light chain (LC8). Here, we detail the use of solution‐state nuclear magnetic resonance spectroscopy to characterize the structure of this self‐association domain, thereby establishing that this domain forms a parallel coiled‐coil and providing insight into how the stability of the dimerization interaction is regulated.
Artificial weathering of surfaces from laminated phenol-formaldehyde resin impregnated compressed wood: impact of top veneer type and overlay application
Authors: Passauer Lars , Schubert Jürgen , Schulz Tino , Flade Philipp , Weiß Björn , Burkhardt Henry 
Published: February 2021

AbstractPanels from laminated phenol-formaldehyde resin (PF) impregnated and compressed wood (Compreg) with top veneers from European species of beech, maple and white birch were prepared, each without or coated with resin pre-impregnated overlay papers. To clarify the outdoor resistance of Compreg surfaces, long-term artificial weathering experiments were performed. Weather-related color changes, gloss retention and microscopic and surface topographical surface alterations were examined. It has been observed that the application of PF impregnated paper overlays and combinations of them with melamine formaldehyde resin (MF) treated films significantly improved the weather resistance of Compreg surfaces. The extent of UV and moisture-induced surface damages of Compreg has been shown to also be dependent on the veneer types used as surface top layer. Highest surface and color stabilization against weather was achieved providing Compreg with top veneers from maple combined with PF overlays or applying both MF and PF impregnated overlay films as surface finish.
Identification of long noncoding RNAs with machine learning methods: a review
Authors: Xu Lei , Jiao Shihu , Zhang Dandan , Wu Song , Zhang Haihong , Gao Bo 
Published: February 2021

AbstractLong noncoding RNAs (lncRNAs) are noncoding RNAs with a length greater than 200 nucleotides. Studies have shown that they play an important role in many life activities. Dozens of lncRNAs have been characterized to some extent, and they are reported to be related to the development of diseases in a variety of cells. However, the biological functions of most lncRNAs are currently still unclear. Therefore, accurately identifying and predicting lncRNAs would be helpful for research on their biological functions. Due to the disadvantages of high cost and high resource-intensiveness of experimental methods, scientists have developed numerous computational methods to identify and predict lncRNAs in recent years. In this paper, we systematically summarize the machine learning-based lncRNAs prediction tools from several perspectives, and discuss the challenges and prospects for the future work.
Scale-up of a Composite Cultured Skin Using a Novel Bioreactor Device in a Porcine Wound Model
Authors: Dearman Bronwyn L , Greenwood John E 
Published: February 2021

Abstract
Extensive deep-burn management with a two-stage strategy can reduce reliance on skin autografts; a biodegradable polyurethane scaffold to actively temporize the wound and later an autologous composite cultured skin (CCS) for definitive closure. The materials fulfilling each stage have undergone in vitro and in vivo pretesting in “small” large animal wounds. For humans, producing multiple, large CCSs requires a specialized bioreactor. This article reports a system used to close large porcine wounds. Three Large White pigs were used, each with two wounds (24.5 cm × 12 cm) into which biodegradable dermal scaffolds were implanted. A sample from discarded tissue allowed isolation/culture of autologous fibroblasts and keratinocytes. CCS production began by presoaking a 1-mm-thick biodegradable polyurethane foam in autologous plasma. In the bioreactor cassette, fibroblasts were seeded into the matrix with thrombin until established, followed by keratinocytes. The CCSs were applied onto integrated dermal scaffolds on day 35, alongside a sheet skin graft (30% of one wound). Serial punch biopsies, trans-epidermal water loss readings (TEWL), and wound measurements indicated epithelialization. During dermal scaffold integration, negligible wound contraction was observed (average 4.5%). After CCS transplantation, the control skin grafts were “taken” by day 11 when visible islands of epithelium were clinically observed on 2/3 CCSs. Closure was confirmed histologically, with complete epithelialization by day 63 post-CCS transplantation (CCS TEWL ~ normal skin average 11.9 g/m2h). Four of six wounds demonstrated closure with robust, stratified epithelium. Generating large pieces of CCS capable of healing large wounds is thus possible using a specialized designed bioreactor.
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis
Authors: Tanner L. , Single A.B. , Bonghir R.K.V , Oomen R. , Wallner O. , Helleday T. , Kalderen C. , Egesten A. 
Published: February 2021

AbstractInterstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues together with aberrant repair processes. Despite substantial advancement in our understanding of IPF progression, numerous questions remain concerning disease pathology. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail to treat underlying causes of disease. The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) is upregulated following TGF-β exposure in several fibrosis-associated cell types. Currently, no pharmaceutical solutions targeting OGG1 have been utilized in the treatment of IPF. In this study, a novel small molecule OGG1 inhibitor, TH5487, decreased myofibroblast transition and associated pro-fibrotic markers in fibroblast cells. In addition, TH5487 decreased pro-inflammatory cytokine production, inflammatory cell infiltration, and lung remodeling in a murine model of bleomycin-induced pulmonary fibrosis. Taken together, these data strongly suggest that TH5487 is a potent, specific, and clinically-relevant treatment for IPF.
Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel
Authors: Hiraki Harrison L. , Matera Daniel L. , Wang William Y. , Zarouk Alexander A. , Argento Anna E. , Buschhaus Johanna M. , Humphries Brock A. , Luker Gary D. , Baker Brendon M. 
Published: February 2021

ABSTRACTThe peritumoral stroma is a complex 3D tissue that provides cells with myriad biophysical and biochemical cues. Histologic observations suggest that during metastatic spread of carcinomas, these cues influence transformed epithelial cells, prompting a diversity of migration modes spanning single cell and multicellular phenotypes. Purported consequences of these variations in tumor escape strategies include differential metastatic capability and therapy resistance. Therefore, understanding how cues from the peritumoral stromal microenvironment regulate migration mode phenotypes has prognostic and therapeutic value. Here, we utilize a synthetic stromal mimetic in which matrix fiber density and bulk hydrogel stiffness can be orthogonally tuned to investigate the contribution of these two key matrix attributes on MCF10A migration mode phenotypes, epithelial-mesenchymal transition (EMT), and invasive potential. We developed an automated computational image analysis framework to extract migratory phenotypes from fluorescent images and determine 3D migration metrics relevant to metastatic spread. Using this analysis, we find that matrix fiber density and bulk hydrogel stiffness distinctly contribute to a variety of MCF10A migration modes including amoeboid, single mesenchymal, multicellular clusters, and collective strands. Taking advantage of the tunability of this material platform, we identify a combination of physical and soluble cues that induces distinct heterogeneous migration modes originating from the same MCF10A spheroid and use this setting to examine a functional consequence of migration mode – apoptotic resistance. We find that cells migrating as part of collective strands are more resistant to staurosporine-induced apoptosis than either disconnected multicellular clusters or individual invading cells. Improved models of the peritumoral stromal microenvironment that help elucidate relationships between matrix attributes and cell migration mode can contribute to ongoing efforts to identify efficacious cancer therapeutics that address migration plasticity-based therapy resistances.
Microbial diversity in tropical marine sediments assessed using culture-dependent and culture-independent techniques
Authors: Demko Alyssa M. , Patin Nastassia V. , Jensen Paul R. 
Published: February 2021

AbstractThe microbial communities associated with marine sediments are critical for ecosystem function yet remain poorly characterized. While culture-independent (CI) approaches capture the broadest perspective on community composition, culture-dependent (CD) methods can capture low abundance taxa that are missed using CI approaches. The aim of this study was to assess microbial diversity in tropical marine sediments collected from five shallow water sites in Belize using both CD and CI approaches. CD methods captured approximately 3% of the >800 genera detected across the five sites. Additionally, 39 genera were only detected using CD approaches revealing rare taxa that were missed with the CI approach. Significantly different communities were detected across sites, with rare taxa playing an important role in the delineation of sediment communities. This study provides important baseline data describing shallow water sediment microbial communities and evidence that standard cultivation techniques may be more effective than previously recognized.Originality-Significance StatementMarine sediments host some of the most diverse microbial communities on the planet. While these communities are critical for global nutrient cycling, the oceanic food web, and the maintenance of ecosystem dynamics, they remain poorly studied. Studies that have assessed sediment communities typically use culture-independent approaches, which have known biases and can miss ecologically important taxa. Here we describe microbial diversity in marine sediments using both culture-dependent and culture-independent approaches. Our culturing approach, sequencing communities as opposed to individual colonies, revealed an additional 39 genera that were not detected with culture-independent methods. Additionally, we cultured numerous, as-yet undescribed species, suggesting that traditional culturing practices can be more efficient than commonly thought. Moreover, our results indicate rare taxa play an important role in distinguishing microbial communities at different sites, thus highlighting the importance of deep sequencing and incorporating culture-dependent approaches for diversity assessments.
Genital and systemic immune effects of the injectable, contraceptive norethisterone enanthate (NET‐EN), in South African women
Authors: Molatlhegi Refilwe P. , Ngcobo Samkelisiwe , Liebenberg Lenine J. P. , Ngcapu Sinaye , Mabhula Amanda , Leslie Alasdair , Mchunu Nobuhle , Zondi Mthobisi M. , Adamson John H. , Govender Katya , Samsunder Natasha , Karim Salim S. Abdool , Karim Quarraisha Abdool , Passmore Jo‐Ann S. , Sivro Aida , McKinnon Lyle R. 
Published: February 2021

AbstractProblemInjectable hormonal contraceptives (IHC) have been associated with altered mucosal and systemic milieu which might increase HIV risk, but most studies have focused on DMPA and not NET‐EN, despite the growing popularity and lower HIV risk associated with the latter in observational studies.Method of studyWe used high‐performance liquid chromatography in combination with tandem triple quadrupole mass spectrometry (HPLC‐LC‐MS/MS) to measure steroid hormones in plasma samples of CAPRISA004 study participants. Concentrations of 48 cytokines were measured in the cervicovaginal lavage (CVL) and plasma, and their expression was compared between participants with detectable NET‐EN (n = 201) versus non‐detectable IHC (n = 90). Each log10 cytokine concentration was tested as an outcome in linear‐mixed models, with NET‐EN detection as the main explanatory variable. Multivariable models were adjusted for potential confounders.ResultsIn bivariate analysis, detectable NET‐EN was associated with reduced cervicovaginal M‐CSF (P = 0.008), GM‐CSF (P = 0.025) and G‐CSF (P = 0.039), and elevated levels MIF (P = 0.008), IL‐18 (P = 0.011), RANTES (P = 0.005) and IL‐1Rα (P < 0.001). Lower G‐CSF (P = 0.011) and elevated IL‐1Rα (P = 0.008) remained significant in adjusted models. Multivariable analyses of plasma samples obtained from NET‐EN‐detectable women showed a significant increase in IP‐10 (P = 0.026) and reductions in TNF‐β (P = 0.037), RANTES (P = 0.009), and M‐CSF (P < 0.001). While similar growth factor reduction in CVL was noted for both DMPA and NET‐EN, similar trends were not observed for endogenous progesterone.ConclusionsDetectable NET‐EN was associated with reduced growth factors in the plasma and genital tract; particularly G‐CSF and M‐CSF. Our results suggest that while NET‐EN is not inflammatory, it may have important immunological effects.
Regular narrow QRS tachycardia. What is the mechanism?
Authors: Mohanan Nair Krishna Kumar , Prabhu Mukund Aravind , Balaguru Sridhar , Namboodiri Narayanan , Valaparambil Ajitkumar 
Published: February 2021

AbstractA 45‐years‐old lady with no structural heart disease on echocardiogram presented with recurrent episodes of palpitation. There was no baseline preexcitation. Twelve lead surface electrocardiograms (ECG) recorded during one of the episodes are provided. What is the likely mechanism of the tachycardia?A)–12 lead surface electrocardiogram during the tachycardia. (B)–12 lead surface electrocardiogram during the tachycardia showing the response to spontaneous ventricular premature beatimage
Comparative assessment of biodegradable-antireflux heparine coated ureteral stent: animal model study
Authors: Soria Federico , de La Cruz Julia E. , Caballero-Romeu Juan Pablo , Pamplona Manuel , Pérez-Fentes Daniel , Resel-Folskerma Luis , Sanchez-Margallo Francisco M. 
Published: February 2021

Abstract
Background
Double J ureteral stents are widely used on urological patients to provide drainage of the upper urinary tract. Unfourtunately, ureteral stents are not free from complications, as bacterial colonization and require a second procedure for removal. The purpose of the current comparative experimental study is to evaluate a new heparin-coated biodegradable antireflux ureteral stent (BraidStent®-H) to prevent urinary bacterial colonization.

Methods
A total of 24 female pigs were underwent determination of bacteriuria and nephrosonographic, endoscopic and contrast fluoroscopy assessment of the urinary tract. Afterward, were randomly assigned animals to Group-I, in which a 5Fr double-pigtail ureteral stent was placed for 6 weeks, or Group-II, in which a BraidStent®-H was placed. Follow-up assessments were performed at 1, 3, 6, 8, 12 weeks. The final follow-up includes the above methods and an exhaustive pathological study of the urinary tract was accomplished after 20 weeks.

Results
Bacteriuria findings in the first 48 h were significant between groups at 6 h and 12 h. Asymptomatic bacteriuria does not reach 100% of the animals in Group-II until 48 h versus Group-I where it appears at 6 h. The weekly bacteriuria mean rate was 27.7% and 44.4% in Group I and II respectively, without statistical significance. In Group II there were no animals with vesicoureteral reflux, with statistical significance at 3 and 6 weeks with Group-I. The 91.2% of stents in Group-II were degraded between 3 and 6 weeks, without obstructive fragments. Distal ureteral peristalsis was maintained in 66.6–75% in Group-II at 1–6 weeks.

Conclusions
The heparin coating of BraidStent® allows an early decrease of bacterial colonization, but its effectiveness is low at the long term. Heparin coating did not affect scheduled degradation rate or size of stents fragments. BraidStent®-H avoids the side effects associated with current ureteral stents, thus should cause less discomfort to patients.
The lifetime risk of revision following total hip arthroplasty
Authors: Nugent Mary , Young Simon W. , Frampton Christopher M. , Hooper Gary J. 
Published: February 2021

Aims Joint registries typically use revision of an implant as an endpoint and report survival rates after a defined number of years. However, reporting lifetime risk of revision may be more meaningful, especially in younger patients. We aimed to assess lifetime risk of revision for patients in defined age groups at the time of primary surgery. Methods The New Zealand Joint Registry (NZJR) was used to obtain rates and causes of revision for all primary total hip arthroplasties (THAs) performed between January 1999 and December 2016. The NZJR is linked to the New Zealand Registry of Births, Deaths and Marriages to obtain complete and accurate data. Patients were stratified by age at primary surgery, and lifetime risk of revision calculated according to age, sex, and American Society of Anesthesiologists (ASA) classification. The most common causes for revision were also analyzed for each age group. Results The overall, ten-year implant survival rate was 93.6% (95% confidence interval (CI) 93.4% to 93.8%). It was lowest in the youngest age group (46 to 50 years), rising sequentially with increasing age to 97.5% in the oldest group (90 to 95 years). Lifetime risk of revision surgery was 27.6% (95% CI 27.3% to 27.8%) in those aged 46 to 50 years, decreasing with age to 1.1% (95% CI 0.0% to 5.8%) in those aged 90 to 95 years at the time of primary surgery. Higher ASA grades were associated with an increased lifetime risk of revision across all ages. The commonest causes for revision THA were aseptic loosening, infection, periprosthetic fracture, and dislocation. Conclusion When counselling patients preoperatively, the lifetime risk of revision may be a more meaningful and useful measure of longer-term outcome than implant survival at defined time periods. This study highlights the considerably increased likelihood of subsequent revision surgery in younger age groups. Cite this article: Bone Joint J 2021;103-B(3):479–485.