bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collisionless Relaxation of a Disequilibrated Current Sheet and Implications for Bifurcated Structures
Authors: Yoon Young Dae , Yun Gunsu , Burch James , Wendel Deirdre 
Published: March 2021

Abstract
Current sheets are ubiquitous plasma structures that play the crucial role of being energy sources for various magnetic phenomena. Although a plethora of current sheet equilibrium solutions have been found, the collisionless process through which a disequilibrated current sheet relaxes or equilibrates remains largely unknown. Here we show, through analyses of phase-space distributions of single-particle orbit classes and particle-in-cell simulations, that collisionless transitions among the orbit classes are responsible for this process. Bifurcated current sheets, which are readily observed in geospace but whose origins remain controversial, are shown to naturally arise from the equilibration process and thus are likely to be the underlying structures in various phenomena; comparisons of spacecraft observations to particle-in-cell simulations support this fact. The bearing of this result on previous explanations of bifurcated structures is also discussed.
How does urbanization affect perceptions and traditional knowledge of medicinal plants?
Authors: Arjona-García Cecilia , Blancas José Juan , Beltrán-Rodríguez Leonardo , López Citlalli , Colín-Bahena Hortencia , Moreno-Calles Ana Isabel , Sierra-Huelz José Antonio , López-Medellín Xavier 
Published: March 2021

Abstract
Background: Use and knowledge of medicinal plants play an essential role in community health in rural Mexico. They are part of the local inheritance and constitute an economic alternative. Nevertheless, knowledge of their use has declined due to factors like accelerated urbanization processes. Some authors have proposed that by reducing natural spaces, urbanization generates changes which will impact recognition, use and management of natural resources. We evaluate how urbanization affects knowledge, use and perception of medicinal plants in a Biosphere Reserve in Mexico. Methods: Using a mixed methodology including quantitative and qualitative analyses, we generate a list of medicinal plants, methods of preparation, prevalence of illness, and use. Results: 210 medicinal plants were identified. The more urbanized community used greater number of introduced plants; whereas the less urbanized used and had more knowledge about wild plants. One of the factors explaining these differences was occupation. People who work outdoors have greater knowledge of wild plants. The more urbanized community knew and used more introduced species. Conclusions: This can lead to a loss of knowledge of use and management of wild species, with implications for the conservation of biocultural heritage. Substitution of native by introduced plants shows disinterest and disuse, which could be reflected in their ecosystems.
Prevalence and Causes of Meatal Stenosis in Circumcised Boys
Authors: Acimi Smail , Abderrahmane Naima , debbous Lamia , Bouziani Nacim , Mansouri Juba , Acimi Mohammed Ali , Boukhari Youcef , Hadjeb Naziha , Yazi Aboubaker essedik 
Published: March 2021

Abstract
The aim of this study was to investigate the prevalence and causes of meatal stenosis after circumcision in children. Between October 2018 and April 2019, we carried out a prospective cross-sectional study on 1031 circumcised boys, aged 5 to 8 years (mean age 6.1 years ± 0.3 years), enrolled in the first level of primary school in Oran (Algeria). All enrolled children underwent a genitourinary examination. Moreover, an anonymous questionnaire was filled-in by one of the parents. The screening revealed the presence of meatal stenosis in 185 children, representing a prevalence of 17.9 % of cases (95% CI = 15.6–20.3). Analysis of the results using both the univariate and multivariate mode brought out some common risk factors such as forceful retraction of the prepuce and the use of a healing product: Beta-sitosterol and Hydrocotyl (Centella Asiatica), rarely Trolamine. In addition, this study showed that boys circumcised during their first week of life are twice as likely to develop meatal stenosis than those circumcised between 7 and 12 months (OR = 2.08; 95% CI = 1.10–3.92, p = 0.021). Conclusion: this study showed that stenosis of the urethral meatus is a frequent complication of circumcision. Circumcision in the first week of life, a foreskin that adheres to the glans, and the use of a healing product were associated with the risk of stenosis development.
Features of hemophagocytic lymphohistiocytosis in the intensive care unit (ICU) : a 260-patient retrospective analysis
Authors: BICHON Amandine , BOURENNE Jérémy , ALLARDET-SERVENT Jérôme , PAPAZIAN Laurent , HRAIECH Sami , GUERVILLY Christophe , PAULY Vanessa , KAPLANSKI Gilles , MOKART Djamel , GAINNIER Marc , CARVELLI Julien 
Published: March 2021

Abstract
Background

Adult hemophagocytic lymphohistiocytosis (HLH) is highly lethal in the ICU. The diagnostic and therapeutic emergency that HLH represents is compounded by its unknown pathophysiological mechanisms. Here, we report on a large cohort of adult-acquired HLH in the ICU. We analyzed prognostic factors associated with mortality to define the diagnostic and therapeutic challenges in this specific population,
Methods

This retrospective study included adult patients diagnosed with HLH in four ICUs in Marseille, France between 2010 and 2020. Patients who fulfilled the HLH-2004 criteria (> 4/8) and/or had an HScore > 169 were diagnosed with HLH. HLH was categorized into four groups according to etiology: sepsis-associated HLH, intracellular infection-associated HLH, malignancy-associated HLH, and idiopathic HLH.
Results

260 patients were included: 121 sepsis-associated HLH (47%), 84 intracellular infection-associated HLH (32%), 28 malignancy-associated HLH (11%), and 27 idiopathic HLH (10%). The ICU mortality rate reached 57% (n = 147/260) without a statistical difference between etiological groups. Independent factors associated with mortality in multivariate analysis included age (OR (5 years) = 1.31 [1.16–1.48], p < 0.0001), SOFA score at ICU admission (OR = 1.37 [1.21–1.56], p < 0.0001), degradation of the SOFA score between ICU arrival and HLH diagnosis (Delta SOFA) (OR = 1.47 [1.28–1.70], p < 0.0001), the presence of bone-marrow hemophagocytosis (OR = 5.27 [1.11–24.97], p = 0.04), highly severe anemia (OR = 1.44 [1.09–1.91], p = 0.01), and hypofibrinogenemia (OR = 1.21 [1.04–1.41], p = 0.02).
Conclusions

In this large retrospective cohort study of critically ill patients, ICU-acquired HLH in adults was associated with a 57% mortality rate, regardless of HLH etiology. Factors independently associated with prognosis included age, presence of hemophagocytosis in bone-marrow aspirates, organ failure at admission, and worsening organ failure during the ICU stay. Whether a rapid diagnosis and the efficacy of specific therapy improve outcome is yet to be prospectively investigated.
Early Versus Late Use of Dexamethasone in Critically Ill Patients With COVID-19: A Multicenter, Prospective Cohort Study
Authors: Sulaiman Khalid Al , Alhubaishi Alaa , Juhani Ohoud Al , Eljaaly Khalid , Harbi Omar Al , Badreldin Hisham A. , Yousif Ghada Al , Vishwakarma Ramesh , Albelwi Shorouq , Almutairi Rahaf , Almousa Maha , Alghamdi Razan , Alharbi Aisha , Algarni Rahmah , Akhani Nada , Atassi Abdulaleam Al , Ghamdi Ghassan Al 
Published: March 2021

Abstract
Background:

Corticosteroids, especially dexamethasone, showed a survival benefit in critically ill COVID 19 patients. However, it is unclear whether the timing of dexamethasone initiation is associated with positive outcomes. The aim of this study is to evaluate the timing of dexamethasone initiation and 30-day ICU mortality in critically ill patients with COVID19.
Methods:

A multicenter, non-interventional, prospective study for all adult COVID19 admitted to intensive care units (ICUs) who received systemic dexamethasone between March 01 to December 31, 2020. Patients were divided into two groups based on the timing for dexamethasone initiation (early vs. late). Early use defined as the initiation of dexamethasone within three days of ICU admission. Multivariate logistic and generalized linear regression were used. We considered a P value of < 0.05 statistically significant.
Results:

A total of 475 patients were included in the study; dexamethasone was initiated early within three days of ICU admission in 433 patients. Early initiation of dexamethasone was associated with lower 30-day ICU mortality (OR [95%CI]: 0.43 [0.23, 0.81], p-value = 0.01), and acute kidney injury during ICU stay, (OR [95%CI]: 0.45 [0.21, 0.94], p-value = 0.03). Additionally, among survivors, early initiation was associated with shorter MV duration (beta coefficient [95% CI]: -0.94 [-1.477, -0.395], p-value = 0.0001), ICU length of stay (LOS) (beta coefficient [95%CI]: -0.73 [-0.9971, -0.469], p-value = 0.0001), and hospital LOS (beta coefficient [95%CI]: -0.68 [-0.913, -0.452], p-value = 0.0001).
Conclusion:

Early initiation of dexamethasone within three days of ICU admission in COVID-19 critically ill patients was associated with a mortality benefit. Additionally, it was associated with shorter MV duration, hospital, and ICU LOS.
Tracking Discussions of Complementary, Alternative, and Integrative Medicine in the Context of the COVID-19 Pandemic: A Month-by-Month Sentiment Analysis of Twitter Data
Authors: Ng Jeremy Y , Abdelkader Wael , Lokker Cynthia 
Published: March 2021

Abstract
Background
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the paucity of evidence, various complementary, alternative and integrative medicines (CAIMs) have been being touted as both preventative and curative. We conducted sentiment and emotion analysis with the intent of understanding CAIM content related to COVID-19 being generated on Twitter across 9 months.
Methods
Tweets relating to CAIM and COVID-19 were extracted from the George Washington University Libraries Dataverse Coronavirus tweets dataset from March 03-November 30, 2020. We trained and tested a machine learning classifier using a large, pre-labelled Twitter dataset, which was applied to predict the sentiment of each CAIM-related tweet, and we used a natural language processing package to identify the emotions based on the words contained in the tweets.
Results
Our dataset included 28713 English-language Tweets. The number of CAIM-related tweets during the study period peaked in May 2020, then dropped off sharply over the summer; the fewest CAIM-related tweets were collected during August 2020 and remained low for the remainder of the collection period. Most tweets (n = 15612, 54%) were classified as positive, 31% were neutral (n = 8803) and 15% were classified as negative (n = 4298). The most frequent emotions expressed across tweets were trust, followed by fear, while surprise and disgust were the least frequent. Though volume of tweets decreased over the 9 months of the study, the expressed sentiments and emotions remained constant.
Conclusion
The results of this sentiment analysis enabled us to establish key CAIMs being discussed at the intersection of COVID-19 across a 9-month period on Twitter. Overall, the majority of our subset of tweets were positive, as were the emotions associated with the words found within them. This may be interpreted as public support for CAIM, however, further qualitative investigation is warranted. Such future directions may be used to combat misinformation and improve public health strategies surrounding the use of social media information.
Did Negative News Regarding the Oxford AstraZeneca Vaccine end in Vaccine Hesitancy? A Repeated Cross-Section Event Study from the UK
Authors: Comerford David , Olivarius Olivia , Bell David , Dawson Alison , Brown Tamara , McGregor Lesley , Pemble Cate , McCabe Louise , Douglas Elaine 
Published: March 2021

Abstract
Vaccine hesitancy is influenced by perceived risk and benefits. On March 15th 2021 various countries suspended use of the Oxford AstraZeneca vaccine against Covid-19 following deaths arising from blood clots. The story became headline news and online search querying vaccine safety increased. What happened to Covid-19 vaccine intentions? We were collecting relevant data at the time. Our survey asked UK adults if they intended to get the vaccine and measured their attitudes towards it. Data collection from respondents before coverage of the story reached its peak (March 12th-15th; n = 241) was compared with responses after the peak (March 17th; n = 305). Our data show no reductions in intentions or attitudes. Our study is uniquely positioned to analyse real-world responses and indicates that media coverage of this story did not reduce intention to take up the vaccine in the UK.
Immunoinformatics Analysis and In-silico Design of Multi- Epitopes Vaccine Against Lassa Virus
Authors: Omoniyi Akinyemi Ademola , Adebisi Samuel Sunday , Musa Sunday Abraham , Nzalak James Oliver , Danborno Barnabas , Bauchi Zainab Maryam , Badmus Iswat Taiwo , Olatomide Oluwasegun Davis , Oladimeji Olalekan Jerry , Nyengaard Jens Randel 
Published: March 2021

Abstract
Lassa virus, an arenavirus, represents the most prevalent human pathogen causing viral haemorrhagic fever. It is endemic in Nigeria and other West African countries. Despite the high burden of the disease, limited treatments are available and no approved vaccine for the prevention of this disease is available. In this study, an immunoinformatics approach was used to predict response of B and T cells from the Lassa virus proteome (GPC, NP, L and Z). The designed chimeric vaccine was modeled, refined, validated and docked with the RIG-I receptor. The docked complex of vaccine-RIG-I was subjected to dynamic stability test and the results suggest that the complex is stable. Validation of the final vaccine construct was done through in silico cloning using E. coli as host. A CAI value of 0.99 suggests that the vaccine construct expressed properly in the host. Immune simulation predicted significantly high levels of IgG1, T-helper, T-cytotoxic cells, INF-γ and IL-2. This theoretical study suggests infection control by creating an effective immunological memory against Lassa virus infections. However, both in vitro and in vivo experiments are needed to validate the immunogenicity and safety of the chimeric vaccine.
Microstructure and Magnetic properties of ferrite nanoparticles synthesized by Co-precipitation method
Authors: Sagayaraj R. , S.Aravazhi  , Chandrasekaran G. 
Published: March 2021

Abstract
In the current research, Cu0.5Co0.3Mo0.2Fe2O4 mixed ferrite nanoparticles have been synthesized using Co-precipitation method. XRD patterns show the development of polyphasic copper, cobalt and molybdenum mixed spinel composition. The particle size of ferrite system is 16nm and they are nanoparticles. The lattice constant was determined to be 8.368 Å used for the highest peak (311). FTIR spectroscopy shows the lower octahedral and higher tetrahedral frequency alignment of ions in the spinel ferrite leading to the octahedral 550 cm− 1 and the tetrahedral 471 cm− 1 vibration modes. TEM micrographs showed spherical morphology and their particle size less than 50 nm, which correlated XRD crystallite size. VSM shows excellent ferrimagnetic properties because of higher coercivity (985.29 G). These higher coercivity materials can make cathode content for Li-ion batteries.
Nanobelts-constructed Porous TiO2-B@SnS2 Heterostructure Hybrids for Enhance Lithium Storage Performance
Authors: Cai Chao , Song Meiyu , Ou Qixiang , Li Jianmei , an changsheng 
Published: March 2021

Abstract
Alloy-type anodes materials possess broad prospects for excellent electrochemical property lithium-ion batteries owing to its high theoretical capacity and excellent electronic conductivity. However, this type electrode materials experience poor kinetics and tremendous volume collapse during the repeated lithiation-delithiation process. Herein, an efficient method to provide a fast transmission channel and suppress the volume collapse during the discharge/charge process by constructing the heterostructure between porous TiO2-B nanoblets and few-layer SnS2 nanosheets interface, which provides high-active sites for the nucleation and growth of SnS2 nanosheets, and inhibits the agglomeration of SnS2 nanosheets. Both experimental results and theoretical calculations definite that porous TiO2 nanobelts provides more chemical active sites for the adsorption and transmission of lithium ion and then effectively improve the stability the electrode structure. As a result, TiO2-B@SnS2 hybrid exhibits excellent rate and cycle performance. This work paves a way to design and construction of high performance alloy-type anode materials.
“Less stress”: a pilot study on a cognitive behavioral treatment program for anxiety in children with autism spectrum disorders
Authors: Oerbeck Beate , Overgaard Kristin Romvig , Attwood Tony , Bjaastad Jon Fauskanger 
Published: March 2021

Abstract

Background:
Comorbid anxiety disorders are prevalent in children with autism spectrum disorders (ASD), but only a minority receives adequate treatment for anxiety. Cognitive behavioral therapy (CBT) has been shown to be effective in treating anxiety disorders. The objectives of the present pilot study were to test the feasibility of the CBT program “Less stress” for comorbid anxiety disorders in children with ASD and explore whether an improvement in diagnostic outcomes for anxiety disorders and symptoms of anxiety was found after treatment.

Methods:
Participants were ten children diagnosed with ASD and anxiety disorders (eight boys, mean age = 9.5 years, range 8 - 12 years). The “Less Stress” program includes three months of weekly treatment sessions followed by three monthly booster sessions. Five therapists participated. A standardized semi-structured diagnostic interview with the mothers was used to assess comorbid disorders. Child anxiety symptoms were measured with the Revised Child Anxiety and Depression Scale (RCADS).

Results:
The therapists found the manual easy to use but adaptations were necessary, particularly shorter sessions due to frequent (n = 7) comorbid Attention-Deficit/Hyperactivity Disorder. The participants found the program useful and the parents noted that they had learned methods they could continue using after the end of the program.
Eight of ten children completed the treatment. Seven of the eight completers benefited from the program. Five of those seven children were free from all anxiety disorders, while two had fewer anxiety disorders. On a group level, a significant mean reduction of anxiety symptoms (RCADS) was found after treatment.

Conclusion:
The therapists found the “Less stress” program to be a feasible intervention in a sample of children with ASD and comorbid anxiety. The significant reduction of anxiety after treatment is promising, but a replication in a larger and more rigorous study is needed to investigate the effectiveness of the intervention.
Frozen Meat-Containing Semi-Finished Minced Products: Biopolymer Packaging Materials
Authors: Korotkiy Igor , Korotkaya Elena , Rasshchepkin Aleksandr , Sahabutdinova Gulnar 
Published: March 2021

Introduction. Meat-containing semi-finished minced products demonstrate a wide variety of properties, as they contain both plant and meat components. This heterogeneity makes it difficult to plan the freezing process. In view of the current environmental situation, packaging films used for cold storage should be biodegradable. The effect of low-temperature freezing and storage on biodegradable polymers remains understudied. The research objective was to find the optimal modes for minced-meat semi-finished products frozen in a biopolymer package.
Study objects and methods. The study featured zrazy, or meat balls, with vegetable filling and a biopolymer film based on corn starch. It involved a laboratory combination freezing and storage cabinet and an XLW(M) tension tester to establish the physical properties of the film.
Results and discussion. The meat-containing semi-finished minced products were vacuum-packaged in biopolymer material and subjected to convection, contact, and combined freezing. The experiments resulted in a new combined method of freezing for biopolymer-packaged semi-finished meat-containing products. The research also tested the strength properties of the CornBag biopolymer film during freezing and cold storage. The paper introduces a graphoanalytic method of calculation of freezing time.
Conclusion. The new combined freezing method involved vacuum packaging, air-blast subfreezing, and further freezing on a refrigerated plate. The biopolymer film proved suitable for freezing and cold storage of food products. It keeps the product from drying, reduces vitamin losses, and preserves sensory properties. The optimal storage mode was –18°C, the maximum storage time – 6 months. The improved freezing technology combined freezing method with convective air-blasting and contact freezing on a refrigerated plate for products pre-packaging in a biopolymer vacuum bag. The optimal freezing parameters: temperature = –40°С, time = 85 min, rate = 1.33 cm/h.
Biocide Effect of Non-Thermal Atmospheric Pressure Plasma
Authors: Petrukhina Daria , Polyakova Irina , Gorbatov Sergei 
Published: March 2021

Introduction. New methods of sterilization with non-thermal atmospheric pressure plasma remain an extremely relevant field of food science. The present research estimated the effect of non-thermal argon plasma on lactic acid bacteria obtained from walnuts.
Study objects and method. The non-thermal argon plasma was generated by electrode discharge induced by a coaxial microwave plasmatron at atmospheric pressure. The discharge was generated in a special electrode construction. Its stability was achieved via low gas flow through the discharge gap. Argon consumption was 10 L/min. The study involved Lactobacillus plantarum and Lactobacillus mali in their natural association and vegetative form. Endo’s medium (Endo agar) was inoculated with lactobacilli. 100 μl of the suspension were added into a Petri dish with nutrient medium and carefully rubbed with a spreader. The plates with Endo agar inoculated with lactobacilli were placed under plasma radiation at a distance of 45 mm. The biocidal effect of plasma radiation was estimated by the diameter of the affected areas. After the plasma treatment, the Petri dishes were incubated in an incubator for 24–48 h at 37°C, after which the diameters of the affected areas were measured again.
Results and discussion. The paper introduces experimental data on the effect of argon plasma on lactobacilli isolated from food. After treating the surface of inoculated Petri dishes with non-thermal plasma for five minutes, the diameter of the inhibition zone reached the diameter of a Petri dish (80 mm) and exceeded the diameter of the spark gap of the plasma generator (36 mm). The temperature on the surface of the nutrient medium during plasma treatment was within the optimal temperature for lactobacillus growth, i.e. 37.3 ± 0.6°C, which excluded thermal effects. Only a few colonies survived a five-minute treatment. After one-minute treatment, the number of survived colony-forming units was considerably higher.
Conclusion. Non-thermal argon plasma treatment proved effective in inhibiting the growth of gram-positive bacteria (Lactobacillus isolated from walnuts) on solid surfaces (agar plates). After five minutes of plasma treatment, the inactivated area (80 mm) exceeded the anode electrode cross section (36 mm) of the plasma generator.