bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy
Authors: Inoue Hiroyuki , Kawaguchi Tsutomu , Ikoma Hisashi , Morimura Ryo , Yamamoto Yusuke , Ochiai Toshiya , Shimizu Hiroki , Arita Tomohiro , Konishi Hirotaka , Shiozaki Atsushi , Kuriu Yoshiaki , Kubota Takeshi , Fujiwara Hitoshi , Okamoto Kazuma , Takahashi Hideo , Takabe Kazuaki , Tsung Allan , Otsuji Eigo 
Published: July 2021

AbstractBackgroundOligometastasis, the presence of a small number of resectable metastatic tumors, usually has favorable outcomes. Here we examined whether the novel oligometastatic score (OLGS), which divides the number of colorectal liver metastases (CRLMs) by the time from colorectal resection to liver recurrence, better predicts CRLM patient survival than the commonly used clinical risk score.MethodsA total of 143 patients who underwent curative hepatectomy for CRLMs between 2007 and 2018 were analyzed. We investigated their clinical characteristics and outcomes using OLGS.ResultsOf the 143 CRLM patients, 70 had synchronous CRLMs and 73 had metachronous CRLMs. Patients with metachronous CRLMs were divided into OLGS‐low (n = 59) and OLGS‐high (n = 14) subgroups. The 5‐year overall survival (OS) rates after hepatectomy differed significantly between the subgroups (p < .001). In the multivariate Cox model, a high OLGS was an independent predictor of 5‐year OS (p < .001), and the hazard ratio (HR) of the OLGS‐high group (HR = 7.171) was higher than that of the high clinical risk score group (HR = 4.337).ConclusionThe OLGS, a simple and handy scoring system, better predicts the 5‐year OS of patients with CRLMs after hepatectomy and warrants prospective validation.
Sleep Performance and Chronotype Behavior in Unilateral Vestibular Hypofunction
Authors: Micarelli Alessandro , Viziano Andrea , Pistillo Rossella , Granito Ivan , Micarelli Beatrice , Alessandrini Marco 
Published: July 2021

ObjectiveTo evaluate sleep behavior and its relation to otoneurological parameters in a group of patients with chronic unilateral vestibular hypofunction (UVH) without self‐reported sleep disturbances when compared with healthy subjects serving as a control group (CG).MethodsFifty‐one patients affected by UVH underwent a retrospective clinical and instrumental otoneurological examination, a 1‐week actigraphy sleep analysis, and a series of self‐report and performance measures (SRM/PM). A CG of 60 gender‐ and age‐matched healthy subjects was also enrolled. A between‐group analysis of variance was performed for each variable, while correlation analysis was performed in UVH patients between otoneurological, SRM/PM, and actigraphy measure scores.ResultsWhen compared with CG subjects, UVH patients were found to be spending less time sleeping and taking more time to go from being fully awake to asleep, based on actigraphy‐based sleep analysis. Also, SRM/PM depicted UVH patients to have poor sleep quality and to be more prone to an evening‐type behavior. Correlations were found between vestibular‐related functionality indexes and subjective sleep quality, as well as between longer disease duration and reduced sleep time.ConclusionFor the first time, a multiparametric sleep analysis was performed on a large population‐based sample of chronic UVH patients. While a different pattern in sleep behavior was found, the cause is still unclear. Further research is needed to expand the extent of knowledge about sleep disruption in vestibular disorders.Level of Evidence3 Laryngoscope, 131:2341–2347, 2021
FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents
Authors: Metelcová Tereza , Vaňková Markéta , Zamrazilová Hana , Hovhannisyan Milena , Staňková Barbora , Tvrzická Eva , Hill Martin , Hainer Vojtěch , Včelák Josef , Kunešová Marie 
Published: July 2021

AbstractPolyunsaturated fatty acids (PUFA) influence many physiological functions. Associations have been found between single nucleotide polymorphisms (SNP) in the FADS1 (Fatty acid desaturase 1) gene and the relative abundance of PUFA in serum lipids. This study examines the relationship between two SNPs in the FADS1 gene (rs174546, rs174537) and the fatty acid (FA) composition of serum lipids in adolescents (13–18 years). We used DNA samples (670 children; 336 girls and 334 boys) from the Childhood Obesity Prevalence and Treatment (COPAT) project. Genomic DNA was extracted from peripheral blood leukocytes in whole blood samples. For genotype analysis, TaqMan SNP Genotyping assays (Applied Biosystems) were used. Fatty acid composition of serum lipids was assessed using gas chromatography. The T‐statistic and regression were used for statistical evaluations. Minor allele T carriers in both SNPs had significant lower level of palmitic acid (16:0, phospholipids) and arachidonic acid (20:4[n‐6], phospholipids) in both sexes. In girls, we found a significant positive association between minor allele T carriers and eicosadienoic acid (20:2[n‐6], cholesteryl esters) in both SNPs. Being a minor allele T carrier was significantly positively associated with dihomo‐γ‐linolenic acid (20:3[n‐6], phospholipids) in boys in both SNPs. SNPs (including rs174546, rs174537) in the FADS gene cluster should have impacted desaturase activity, which may contribute to different efficiency of PUFA synthesis.
SLC10A2 deficiency‐induced congenital chronic bile acid diarrhea and stunting
Authors: Qie Di , Zhang Yulin , Gong Xue , He Yunru , Qiao Lina , Lu Guoyan , Li Yifei 
Published: July 2021

AbstractBackgroundDiarrhea is a common occurrence in children below the age of 5 years. In chronic cases, it induces malnutrition that severely stunts growth. Bile acid diarrhea (BAD), caused by malabsorption of bile acid (BA), is a rare form of chronic diarrhea seldom observed in pediatric patients. Here, we present a clinical report on a novel case of chronic BAD, with severe stunting in an infant, induced by a homozygous mutation of SLC10A2.MethodsWe performed DNA extraction, whole‐exome sequencing analysis, and mutation analysis of SLC10A2 to obtain genetic data on the patient. We subsequently analyzed the patient's clinical and genetic data.ResultsThe patient's clinical manifestations were chronic diarrhea with increased BAs in the feces and extreme stunting, which was diagnosed as BAD. A homozygous mutation of SLC10A2 at the c.313T>C (rs201206937) site was detected.ConclusionOur report reveals the youngest case illustrating the characteristics of BAD induced by genetic variant at 313T>C, and the second case entailing a clear association between a SLC10A2 genetic mutation and the onset of BAD. Our findings expand the mutant spectrum of the SLC10A2 gene and contribute to the refinement of the genotype–phenotype mapping of severe stunting induced by pediatric BAD. Moreover, they highlight the value of molecular genetic screening for diagnosing BAD in young patients.
Low‐profile compact metasurface‐loaded patch antenna with enhanced bandwidth
Authors: Wan Weikang , Xue Mei , Cao Liqiang , Ye Tianchun , Wang Qidong 
Published: July 2021

AbstractIn this article, a low‐profile wideband metasurface‐loaded patch antenna is proposed. The antenna utilizes a compact structure of square ring type metasurface loaded patch to increase the bandwidth of traditional microstrip patch antenna. By introducing a patch‐induced metasurface mode at higher frequency combined with the fundamental patch mode at lower frequency in the band of interest, a dual‐mode operation is revealed with the aid of characteristic mode analysis. Compared with conventional metasurface antenna fed by a long radiating slot, the proposed antenna can achieve a 30% reduction in aperture size with a simpler configuration, clear dual‐mode operation and significant improvement of backward radiation. To validate the concept, a 1 × 4 array prototype of proposed antenna is manufactured under a low profile of 0.04λ0 (λ0 is the free space wavelength at 27.5 GHz). The measured results indicate the antenna array achieves a wide impedance bandwidth of 22.8% with a peak realized gain of 13.1 dBi and a high front‐to‐back ratio over 20 dB.
35Cl–1H Heteronuclear correlation magic‐angle spinning nuclear magnetic resonance experiments for probing pharmaceutical salts
Authors: Iuga Dinu , Corlett Emily K. , Brown Steven P. 
Published: July 2021

AbstractHeteronuclear multiple‐quantum coherence (HMQC) pulse sequences for establishing heteronuclear correlation in solid‐state nuclear magnetic resonance (NMR) between 35Cl and 1H nuclei in chloride salts under fast (60 kHz) magic‐angle spinning (MAS) and at high magnetic field (a 1H Larmor frequency of 850 MHz) are investigated. Specifically, recoupling of the 35Cl–1H dipolar interaction using rotary resonance recoupling with phase inversion every rotor period or the symmetry‐based SR421 pulse sequences are compared. In our implementation of the population transfer (PT) dipolar (D) HMQC experiment, the satellite transitions of the 35Cl nuclei are saturated with an off‐resonance WURST sweep, at a low nutation frequency, over the second spinning sideband, whereby the WURST pulse must be of the same duration as the recoupling time. Numerical simulations of the 35Cl–1H MAS D‐HMQC experiment performed separately for each crystallite orientation in a powder provide insight into the orientation dependence of changes in the second‐order quadrupolar‐broadened 35Cl MAS NMR lineshape under the application of dipolar recoupling. Two‐dimensional 35Cl–1H PT‐D‐HMQC MAS NMR spectra are presented for the amino acids glycine·HCl and l‐tyrosine·HCl and the pharmaceuticals cimetidine·HCl, amitriptyline·HCl and lidocaine·HCl·H2O. Experimentally observed 35Cl lineshapes are compared with those simulated for 35Cl chemical shift and quadrupolar parameters as calculated using the gauge‐including projector‐augmented wave (GIPAW) method: the calculated quadrupolar product (PQ) values exceed those measured experimentally by a factor of between 1.3 and 1.9.
Improving deuterium metabolic imaging (DMI) signal‐to‐noise ratio by spectroscopic multi‐echo bSSFP: A pancreatic cancer investigation
Authors: Peters Dana C. , Markovic Stefan , Bao Qingjia , Preise Dina , Sasson Keren , Agemy Lilach , Scherz Avigdor , Frydman Lucio 
Published: July 2021

PurposeDeuterium metabolic imaging (DMI) maps the uptake of deuterated precursors and their conversion into lactate and other markers of tumor metabolism. Even after leveraging 2H’s short T1s, DMI’s signal‐to‐noise ratio (SNR) is limited. We hypothesize that a multi‐echo balanced steady‐state free precession (ME‐bSSFP) approach would increase SNR compared to chemical shift imaging (CSI), while achieving spectral isolation of the metabolic precursors and products.MethodsSuitably tuned 2H ME‐bSSFP (five echo times [TEs], ΔTE = 2.2 ms, repetition time [TR]/flip‐angle = 12 ms/60°) was implemented at 15.2T and compared to CSI (TR/flip‐angle = 95 ms/90°) regarding SNR and spectral isolation, in simulations, in deuterated phantoms and for the in vivo diagnosis of a mouse tumor model of pancreatic adenocarcinoma (N = 10).ResultsSimulations predicted an SNR increase vs. CSI of 3‐5, and that the peaks of 2H‐water, 2H6,6’‐glucose, and 2H3,3’‐lactate can be well isolated by ME‐bSSFP; phantoms confirmed this. In vivo, at equal spatial resolution (1.25 × 1.25 mm2) and scan time (10 min), 2H6,6’‐glucose’s and 2H3,3’‐lactate’s SNR were indeed higher for bSSFP than for CSI, three‐fold for glucose (57 ± 30 vs. 19 ± 11, P < .001), doubled for water (13 ± 5 vs. 7 ± 3, P = .005). The time courses and overall localization of all metabolites agreed well, comparing CSI against ME‐bSSFP. However, a clearer localization of glucose in kidneys and bladder, the detection of glucose‐avid rims in certain tumors, and a heterogeneous pattern of intra‐tumor lactate production could only be observed using ME‐bSSFP’s higher resolution.ConclusionsME‐bSSFP provides greater SNR per unit time than CSI, providing for higher spatial resolution mapping of glucose uptake and lactate production in tumors.
Bilanzen der Laborzulieferer ‐ Nachfrage und Nachschub
Authors: Zbikowski Frauke 
Published: July 2021

AbstractAnders als in der Gesamtwirtschaft lief es im Jahr 2020 bei den Laborzulieferern: Für einige gehörte es zu den erfolgreichsten der Unternehmensgeschichte. Die große Nachfrage – vor allem nach Verbrauchsmaterialien – konnten die Hersteller allerdings oft nicht bedienen. Aufgrund der Pandemie stockten die Lieferketten.
Nachruf: Bernhard Fell (1929 – 2021)
Authors: Cornely Wolfgang , Liauw Marcel , Offermanns Heribert 
Published: July 2021

AbstractBernhard Fell (hier mit seiner Frau, gemalt von seiner Tochter) war „Mann der ersten Stunde“ beim Aufbau des Aachener Instituts für Technische Chemie.
Initial experience using a novel nerve stimulator for the management of pudendal neuralgia
Authors: Hoang Roberts Ly , Vollstedt Annah , Volin Joshua , McCartney Teresa , Peters Kenneth M. 
Published: July 2021

AbstractAimsIn patients with pudendal neuralgia, prior studies have shown efficacy in chronic stimulation with Interstim® (Medtronic, Inc.). This feasibility study reports on the initial experience of using a wireless system to power an implanted lead at the pudendal nerve, StimWave®, to treat pudendal neuralgia.MethodsRetrospective chart review identified patients with a lead placed at the pudendal nerve for neuralgia and powered wirelessly. Clinical outcomes were assessed at Postoperative visits and phone calls. Administered non‐validated follow‐up questionnaire evaluated the Global Response Assessment, percentage of pain improvement, satisfaction with device, and initial and current settings of the device (h/day of stimulation).ResultsThirteen patients had the StimWave® lead placed at the pudendal nerve, 12 (92%) female and 1 (7.6%) male. Mean age was 50 years (range: 20–58). Failed prior therapies include medical therapy (100%), pelvic floor physical therapy (92%), pudendal nerve blocks (85%), pelvic floor muscle trigger point injections (69%), neuromodulation (30.7%), or surgeries for urogenital pain (23.1%). After the trial period, 10/13 (76.9%) had >50% improvement in pain with 6/13 (46.1%) reporting 100% pain improvement. Nine underwent permanent lead placement. At last postoperative visit (range, 6–83 days), 5/9 patients reported >50% pain improvement. Seven patients reached for phone calls (22–759 days) reported symptoms to be “markedly improved” (n = 2), “moderately improved” (n = 4), or “slightly improved” (n = 1). At follow up, complications included lead migration (n = 2), broken wire (n = 1), or nonfunctioning antenna (n = 2).ConclusionComplex patients with pudendal neuralgia may benefit from pudendal nerve stimulation via StimWave®.
Body composition measures may help target fundamental nutritional nursing efforts in rehabilitating patients with acquired brain injury
Authors: Aadal Lena , Odgaard Lene , Feldbæk Nielsen Jørgen , Rasmussen Henrik Højgaard , Holst Mette 
Published: July 2021

AbstractAimTo illuminate using body composition measurements for malnutrition measured by Bio Impedance Analysis (BIA), as opposed to body mass index (BMI), and discuss benefits and burdens for fundamental nursing care.DesignA second analysis of a prospective, descriptive cohort study, targeting fundamental nursing care elements.MethodsThis postevaluation study explored data from a prospective, descriptive cohort study, which consecutively included 92 patients admitted for neurorehabilitation care. Measures of nutritional status were BMI and FFMI. Chi‐Square test and Multivariable logistic regression were used.ResultsBody composition measures rather than BMI contributed to target individual nutritional nursing care as this measure detected more patients at potential risk of malnutrition and indicated minor changes in the nutritional state. Transitions from being malnourished to a normal nutritional status occurred in 29% using the BMI definition while it was the case in 40% of individuals with malnutrition defined by the body composition.
Sleep fragmentation and the risk of obesity: The Sleep Heart Health Study
Authors: Zhao Binbin , Sun Shuliu , He Xiaoyan , Yang Jian , Ma Xiancang , Yan Bin 
Published: July 2021

AbstractObjectiveSleep disturbances have been recognized as a risk factor for obesity. This study used polysomnography records to investigate associations between sleep fragmentation and obesity.MethodsObjectively measured sleep fragmentation data recorded by in‐home polysomnography, including total arousal index (ArI‐total), ArI in rapid eye movement (REM) sleep (ArI‐REM), ArI in non‐REM sleep (ArI‐NREM), sleep fragmentation index, sleep efficiency (SE), and wake after sleep onset (WASO), were based on the Sleep Heart Health Study (2,835 men and 2,888 women with a mean [SD] age of 63.2 [11.2] years). Multivariable regression analyses were used to examine the relationship between sleep fragmentation and obesity.ResultsMultinomial logistic regression showed that participants with obesity have a significantly higher ArI‐total (odds ratio [OR] 1.018; 95% CI: 1.010‐1.026, p < 0.001), ArI‐REM (OR 1.010; 95% CI: 1.002‐1.018, p = 0.009), ArI‐NREM (OR 1.017; 95% CI: 1.009‐1.024, p < 0.001), and WASO (OR 1.003; 95% CI: 1.001‐1.005, p = 0.007) compared with those with normal weight. Furthermore, multiple linear regression analyses showed an obvious correlation between ArI‐total, ArI‐REM, ArI‐NREM, SE, WASO, and BMI.ConclusionsThe results revealed that ArI‐total, ArI‐REM, ArI‐NREM, SE, and WASO were associated with obesity. The improvement of sleep fragmentation may contribute to decreasing the risk of obesity.
Guaranteed cost control for semi‐Markovian jump systems by a conditionally mode‐dependent controller
Authors: Wang Guoliang , Song Ge , Wang Xiaoqiang 
Published: July 2021

AbstractThis article considers the guaranteed cost control problem of continuous‐time semi‐Markovian jump system. First, a conditionally mode‐dependent controller is proposed, which includes mode‐dependent and ‐independent controllers as special cases. Via exploiting a Lyapunov function method and enlarging techniques, sufficient LMI conditions are presented for solving such a controller directly. All the features such as conditional probability, sojourn time, and transition probability are involved. More extensions about general conditional probabilities such as uncertain and partially unknown cases are considered. Finally, a practical example is given to illustrate the effectiveness and superiority of the proposed methods.
Synergistic toughening of poly(lactic acid)/poly(ethylene vinyl acetate) (PLA/EVA) by dynamic vulcanization and presence of hydrophobic nanoparticles
Authors: Lohrasbi Pardis , Yeganeh Jafar Khademzadeh 
Published: July 2021

AbstractThe presented research reports a successful preparation of a super toughened poly(lactic acid)/poly(ethylene vinyl acetate) (PLA/EVA) blend using simultaneous dicumyl peroxide (DCP)‐induced dynamic vulcanization and addition of hydrophobic spherical silica nanoparticles (NPs). The torque evolution during melt mixing of the samples was assessed to track the dynamic vulcanization process. NPs were localized mainly in the EVA droplets and at the interface where a layer of particles was formed with a small amount dispersed in the PLA matrix. The incorporation of NPs or DCP induced compatibilization, causing a drastic decline in the size of EVA droplets in addition to improving the interfacial adhesion. On the other hand, simultaneous dynamic vulcanization and NPs incorporation synergistically affected the compatibilization of EVA and PLA phases. Differential scanning calorimetry (DSC) was employed to analyze the thermal transition and crystallization behavior of the samples. Simultaneous incorporation of silica nanoparticles and DCP at an optimum content significantly improved the tensile toughness, elongation at break, and impact strength, giving rise to super toughened PLA/EVA blend. The elongation at break and impact strength of the dynamically vulcanized PLA/EVA blend containing 5% nanosilica showed an increase from 7% to 175% and 5.1 to more than 77 kJ/m2, respectively as compared to the neat sample. Based on SEM analysis of the fractured surface of the tensile samples, cavitation in combination with intensive shear yielding of the matrix were dominating toughening mechanisms. Finally, the effect of DCP and NPs on the microstructural properties of the sample was investigated through rheological evaluations.
Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities
Authors: Arab‐Ahmadi Samira , Irani Shiva , Bakhshi Hadi , Atyabi Fatemeh , Ghalandari Behafarid 
Published: July 2021

AbstractDesigning scaffolds with therapeutic potential to stimulate angiogenesis and osteogenesis is considered a promising strategy in the regeneration of large skeletal defects. In this study, the cobalt ions (Co2+) were incorporated in laponite (LAP) nanodiscs (0.65, 1.3, and 2.6 g/L) and, in combination with carboxymethyl chitosan (CMC), were immobilized on the electrospun polycaprolactone (PCL) nanofiber to fabricate scaffolds for simultaneous enhancing osteogenesis and angiogenesis inductions to human bone marrow mesenchymal stem cells. The Fourier transform infrared, energy dispersive X‐ray, and inductively coupled plasma atomic emission spectrometries confirmed the Co2+‐loading on the LAP nanodiscs and the chemical immobilization on the surface of PCL nanofibers. The result of MTT assay, scanning electron microscopy, and fluorescence staining displayed that Co2+‐loaded scaffolds were biocompatible. Furthermore, the incorporation of Co2+ ions into LAP nanodiscs had significant effects on the calcium deposition and expression of osteogenic markers, alkaline phosphatase and osteonectin, as well as, the expression of angiogenic markers, hypoxia‐inducible factor‐1α and vascular endothelial growth factor of the cells seeded on the scaffolds (p ≤ 0.05). These results suggested that the combination of Co2+ ions with CMC/LAP could result in a synergetic effect on the osteogenesis and angiogenesis stimulations.