bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Dose Fluorescein Reveals Unusual Confocal Endomicroscope Imaging of Low-Grade Glioma
Authors: Belykh Evgenii , Onaka Naomi R. , Zhao Xiaochun , Abramov Irakliy , Eschbacher Jennifer M. , Nakaji Peter , Preul Mark C. 
Published: July 2021

Background: Fluorescence-guided brain tumor surgery using fluorescein sodium (FNa) for contrast is effective in high-grade gliomas. However, the effectiveness of this technique for visualizing noncontrast-enhancing and low-grade gliomas is unknown. This report is the first documented case of the concurrent use of wide-field fluorescence-guided surgery and confocal laser endomicroscopy (CLE) with high-dose FNa (40 mg/kg) for intraoperative visualization of tumor tissue cellularity in a nonenhancing glioma.Case Description: A patient underwent fluorescence-guided surgery for a left frontal lobe mass without contrast enhancement on magnetic resonance imaging. The patient received 40 mg/kg FNa intravenously at the induction of anesthesia. Surgery was performed under visualization with a Yellow 560 filter and white-light wide-field imaging. Intraoperative CLE produced high-quality images of the lesion 1.5 h after FNa injection. Frozen-section analysis demonstrated findings comparable to those of intraoperative CLE visualization and consistent with World Health Organization (WHO) glioma grades II–III. The patient recovered without complications. Analysis of the permanent histologic sections identified the tumor as an anaplastic oligodendroglioma, IDH-mutant, 1p/19q co-deleted, consistent with WHO grade III because of discrete foci of hypercellularity and increased mitotic figures, but large regions of the lesion were low grade.Conclusions: The use of high-dose FNa in this patient with a nonenhancing borderline low-grade/high-grade glioma produced actionable wide-field fluorescence imaging using the operating microscope and improved CLE visualization of tumor cellularity. Higher doses of FNa for intraoperative CLE imaging and possible simultaneous wide-field fluorescence surgical guidance in nonenhancing gliomas merit further investigation.
Spin in Published Reports of Tinnitus Randomized Controlled Trials: Evidence of Overinterpretation of Results
Authors: Velde Hedwig M. , van Heteren Jan A. A. , Smit Adriana L. , Stegeman Inge 
Published: July 2021

Background: Spin refers to reporting practices that could distort the interpretation and mislead readers by being more optimistic than the results justify, thereby possibly changing the perception of clinicians and influence their decisions. Because of the clinical importance of accurate interpretation of results and the evidence of spin in other research fields, we aim to identify the nature and frequency of spin in published reports of tinnitus randomized controlled trials (RCTs) and to assess possible determinants and effects of spin.Methods: We searched PubMed systematically for RCTs with tinnitus-related outcomes published from 2015 to 2019. All eligible articles were assessed on actual and potential spin using prespecified criteria.Results: Our search identified 628 studies, of which 87 were eligible for evaluation. A total of 95% of the studies contained actual or potential spin. Actual spin was found mostly in the conclusion of articles, which reflected something else than the reported point estimate (or CI) of the outcome (n = 34, 39%) or which was selectively focused (n = 49, 56%). Linguistic spin (“trend,” “marginally significant,” or “tendency toward an effect”) was found in 17% of the studies. We were not able to assess the association between study characteristics and the occurrence of spin due to the low number of trials for some categories of the study characteristics. We found no effect of spin on type of journal [odds ratio (OR) −0.13, 95% CI −0.56–0.31], journal impact factor (OR 0.17, 95% CI −0.18–0.51), or number of citations (OR 1.95, CI −2.74–6.65).Conclusion: There is a large amount of spin in tinnitus RCTs. Our findings show that there is room for improvement in reporting and interpretation of results. Awareness of different forms of spin must be raised to improve research quality and reduce research waste.
Efficacy and Prognostic Factors of Trans-Arterial Chemoembolization Combined With Stereotactic Body Radiation Therapy for BCLC Stage B Hepatocellular Carcinoma
Authors: Jiang Changchen , Jing Shenghua , Zhou Han , Li Aomei , Qiu Xiangnan , Zhu Xixu , Shen Zetian 
Published: July 2021

PurposeThis study aimed to evaluate the efficacy and safety of trans-arterial chemoembolization (TACE) followed by stereotactic body radiation therapy (SBRT) in treating Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) not amenable to resection and radiofrequency ablation (RFA).MethodsFrom February 2012 to January 2017, a total of 57 BCLC stage B HCC patients who were unsuitable candidates for resection and RFA treated with TACE combined with CyberKnife SBRT were included in this retrospective study. Patients underwent TACE for a median of two times (1–5 times) before SBRT. SBRT prescription doses ranged from 30 Gy to 50 Gy in 3–5 fractions.ResultsThe median follow-up time was 42 months. The objective response rate (CR + PR) was 85.9%, and the disease control rate (CR + PR + SD) was 96.5%. The local control (LC) rates were 91.1% and 84.3% at 1 and 2 years, respectively. The 1-, 2-, 3-year overall survival (OS) and the median survival time were 73.2%, 51.4%, 32.4% and 26.6 months, respectively. The 1-, 2-, and 3-year progression-free survival (PFS) were 34.2%, 21.6%, and 9%, respectively, with a median PFS time of 9.7 months. A subgroup analysis was conducted in 32 patients with AFP ≥ 200 ng/ml before TACE. OS was significantly prolonged in those with AFP that decreased by more than 75% than those with AFP that decreased by less than 75% (P = 0.018) after SBRT. The treatment was well tolerated with only one patient (1.8%) developed grade 3 gastrointestinal toxicity, and another patient developed non-classical RILD. In multivariate analysis, tumor length ≥ 10 cm and AFP ≥ 200 ng/ml were independent poor prognostic factors for OS.ConclusionThe combination of TACE and Cyberknife SBRT showed optimal efficacy with acceptable toxicity for BCLC stage B HCC.
A Deep Unsupervised Learning Model for Artifact Correction of Pelvis Cone-Beam CT
Authors: Dong Guoya , Zhang Chenglong , Liang Xiaokun , Deng Lei , Zhu Yulin , Zhu Xuanyu , Zhou Xuanru , Song Liming , Zhao Xiang , Xie Yaoqin 
Published: July 2021

PurposeIn recent years, cone-beam computed tomography (CBCT) is increasingly used in adaptive radiation therapy (ART). However, compared with planning computed tomography (PCT), CBCT image has much more noise and imaging artifacts. Therefore, it is necessary to improve the image quality and HU accuracy of CBCT. In this study, we developed an unsupervised deep learning network (CycleGAN) model to calibrate CBCT images for the pelvis to extend potential clinical applications in CBCT-guided ART.MethodsTo train CycleGAN to generate synthetic PCT (sPCT), we used CBCT and PCT images as inputs from 49 patients with unpaired data. Additional deformed PCT (dPCT) images attained as CBCT after deformable registration are utilized as the ground truth before evaluation. The trained uncorrected CBCT images are converted into sPCT images, and the obtained sPCT images have the characteristics of PCT images while keeping the anatomical structure of CBCT images unchanged. To demonstrate the effectiveness of the proposed CycleGAN, we use additional nine independent patients for testing.ResultsWe compared the sPCT with dPCT images as the ground truth. The average mean absolute error (MAE) of the whole image on testing data decreased from 49.96 ± 7.21HU to 14.6 ± 2.39HU, the average MAE of fat and muscle ROIs decreased from 60.23 ± 7.3HU to 16.94 ± 7.5HU, and from 53.16 ± 9.1HU to 13.03 ± 2.63HU respectively.ConclusionWe developed an unsupervised learning method to generate high-quality corrected CBCT images (sPCT). Through further evaluation and clinical implementation, it can replace CBCT in ART.
Utopia sabática: Adorno e o capitalismo como religião
Authors: Santos Jéverton Soares dos 
Published: July 2021

Este texto faz parte dos esforços do autor de empreender uma hermenêutica messiânica do pensamento de Theodor Adorno. Assim sendo, o objeto deste artigo é o mote do capitalismo como religião que aparece de uma forma marginal no interior da tradição do marxismo ocidental e que foi, recentemente, rearticulado pela pesquisa seminal de Michael Löwy. Para isso, este artigo procurou resgatar alguns motivos messiânicos de História e Consciência de Classe (Introdução). Feito isso, almejou-se mostrar como Adorno procurou cobrir as lacunas filosóficas da obra de Lukács a partir da noção de reconciliação (Seção 1). A seguir, mostrou-se como a Minima Moralia faz uma crítica intra e extratextual à hipóstase do trabalho como redenção, oriunda de uma tradição teológica que remonta à divinização do sofrimento cujo paradigma é a Magna Moralia, obra patrística sobre a personagem bíblica de Jó (Seção 2). Assim, constatou-se que várias observações adornianas sobre o caráter infernal do capitalismo coincidem com as atuais – e não menos perturbadoras – reflexões do filósofo germano-coreano Byung-Chul Han e sua caracterização da sociedade neoliberal como uma sociedade do cansaço não-redentor (Seção 3). Sendo assim, demonstrar-se-á como o ensejo utópico de uma sociedade-sem-trabalho, resgatado de forma brilhante por Han, corresponde com as aspirações da filosofia da redenção de Adorno (Seção 4). Por último, a partir do paradigma judaico do “Shabat”, analisar-se-á a defesa de Han e Adorno de uma utopia sabática como protótipo do fim do capitalismo como religião (Seção 5).

Palavras-chave: capitalismo como religião; reconciliação; trabalho; utopia sabática;
Filosofia, literatura e descrença no Diálogo entre um Padre e um Moribundo do Marquês de Sade
Authors: Primo Marcelo de Sant'Anna Alves 
Published: July 2021

Que Sade foi um filósofo, literato e ateu não se tem a menor dúvida. Nesse sentido, o objetivo do presente artigo é mostrar como se articulam as três facetas supracitadas do marquês na leitura do seu texto inaugural Diálogo entre um padre e um moribundo, de 1782. Através do estilo e estrutura clássicos do diálogo, o escritor desfere contundentes ataques, ambientado em uma alcova, resultando em: 1) a crítica à exploração do medo nos homens pelos cristãos no momento da morte; 2) e, consequentemente, recusa a existência de deus quando opõe a razão e os sentidos às quimeras religiosas. Contudo, Sade vai muito mais além do que usar a arte do diálogo filosófico para encarar tête-à-tête os dogmas da religião: a defesa de uma postura serena diante da morte não significa ficar somente no plano do discurso, já que o subverte introduzindo a ação em vez de explicar através de conceitos o que seria a natureza corrompida do homem. Logo, podemos concluir que o Diálogo passa dos limites de uma simples manifestação literária do materialismo ateu sadeano sendo, na verdade, um autêntico escrito de resistência que, tendo como marco inicial o desamparo do homem, afirma o corpo para superá-lo explorando os prazeres corporais ao extremo.
Palavras-chave: Sade. Filosofia. Literatura. Ateísmo.
A South African Public Law Perspective on Digitalisation in the Health Sector
Authors: Cachalia Firoz , Klaaren Jonathan 
Published: July 2021

We explored some of the questions posed by digitalisation in an accompanying working paper focused on constitutional theory: Digitalisation, the ‘Fourth Industrial Revolution’ and the Constitutional Law of Privacy in South Africa. In that paper, we asked what legal resources are available in the South African legal system to respond to the risk and benefits posed by digitalisation. We argued that this question would be best answered by developing what we have termed a 'South African public law perspective'. In our view, while any particular legal system may often lag behind, the law constitutes an adaptive resource that can and should respond to disruptive technological change by re-examining existing concepts and creating new, more adequate conceptions. Our public law perspective reframes privacy law as both a private and a public good essential to the functioning of a constitutional democracy in the era of digitalisation. In this working paper, we take the analysis one practical step further: we use our public law perspective on digitalisation in the South African health sector. We do so because this sector is significant in its own right – public health is necessary for a healthy society – and also to further explore how and to what extent the South African constitutional framework provides resources at least roughly adequate for the challenges posed by the current 'digitalisation plus' era.	The theoretical perspective we have developed is certainly relevant to digitalisation’s impact in the health sector. The social, economic and political progress that took place in the 20th century was strongly correlated with technological change of the first three industrial revolutions. The technological innovations associated with what many are terming ‘the fourth industrial revolution’ are also of undoubted utility in the form of new possibilities for enhanced productivity, business formation and wealth creation, as well as the enhanced efficacy of public action to address basic needs such as education and public health.
«Situm in loco alto et forti». Una controversia del vescovo Andrea de’ Mozzi per il monastero di San Miniato
Authors: Tanzini Lorenzo 
Published: July 2021

The essay analyses a judicial case of the late 13th century (preserved in the archival funds of the Pistoiese bishopric), in which the bishop of Florence Andrea Mozzi and the nuns of Monticelli (one of the earliest Franciscan female communities in Florence) quarrel for the rights on the church of San Miniato, under the protection of the bishop since the origin of the monastic community in the early 11th century. As usual for this kind of sources, the text provides us with an important array of informations: the references to the written records the contenders used draw an image of the documentary landscape of the monastic communities since the 11th century, and at the same time the narrative of the religious practices of the laity around the church are very well described.
Particle size distribution of airborne particulate matter in Petropavlovsk-Kamchatsky and Yelizovo based on the results of several years of study
Authors: Kholodov A. S. , Kirichenko K. Yu. , Golokhvast K. S. 
Published: July 2021

Introduction. Kamchatka Krai is a region with low population density and poorly developed industry. However, in large cities the air quality is degraded due to economic activity. Aim. To study the concentration of airborne particulate matter (in particular, up to 1 µm and up to 10 µm) in Petropavlovsk-Kamchatsky and Yelizovo air and carry out a comparative analysis with the previously obtained results of environmental monitoring of atmospheric suspension.Materials and methods. Airborne particulate matter was studied in snow which was collected during snowfalls to avoid its secondary pollution by anthropogenic aerosols. The melted snow was analyzed on a Fritsch Analysette 22 NanoTech laser particle analyzer (Germany).Results. PM1 particles were found in five snow samples taken in Petropavlovsk-Kamchatsky. The quantity of PM₁₀ is low in all samples, and only in two of six sampled areas it reaches 12%. Compared to the results of previous studies, the concentration of PM1 is at the same level as in previous years, and the content of PM₁₀ has decreased. In samples from Yelizovo, the same trends are observed. Compared to 2018, when a high concentration of PM₁₀ particles was found in almost all samples, reaching 57.2%, there is a trend towards a decrease in the concentration of the potentially hazardous PM fraction.Conclusion. Updated data on the particle size distribution of airborne particulate matter in two cities of the Kamchatka Peninsula were obtained. In the snow samples collected in Petropavlovsk-Kamchatsky and Yelizovo, we found PM₁ and PM₁₀ particles hazardous to human health, although their concentration is generally lower than in previous years of the study.
Gambaran Perilaku Wanita Hamil dalam Melakukan Antenatal Care saat Pandemi Covid-19 di Puskesmas Rawat Inap Sidomulyo, Kota Pekanbaru
Authors: Refiani Diny , Dewi Yulia Irvani , Utami Sri 
Published: July 2021

Pandemi COVID-19 sangat berdampak terhadap layanan Kesehatan Ibu dan Anak (KIA) dengan terjadinya penurunan jumlah kunjungan ibu hamil untuk memeriksakan kehamilan. Tujuan penelitian untuk mengetahui gambaran perilaku ibu hamil dalam melakukan antenatal care (ANC) saat pandemi COVID-19. Penelitian ini menggunakan desain deskriptif kuantitatif. Sampel penelitian adalah 40 wanita hamil trimester III yang melakukan pemeriksaan ANC dari bulan November 2020 sampai Januari 2021 dengan teknik accidental sampling. Analisis yang digunakan adalah analisis univariat. Hasil penelitian ini menunjukkan bahwa mayoritas ibu hamil berumur 20-35 tahun (usia produktif) sebanyak 34 responden (85%), pendidikan terakhir SMA/SMK/MAN sebanyak 21 responden (52,5%) dan mayoritas tidak bekerja sebanyak 26 responden (65%). Perilaku wanita hamil dalam melakukan ANC saat pandemi COVID-19 menunjukkan hasil yang hampir seimbang antara perilaku positif sebanyak 21 responden (52,5%) dan perilaku negatif sebanyak 19 responden (47,5%). Sebagian besar perilaku wanita hamil berdasarkan pedoman pelaksanaan ANC saat pandemi COVID-19 adalah negatif sebanyak 24 responden (60%). Sebagian besar perilaku ibu hamil berdasarkan upaya pencegahan COVID-19 dengan menerapkan protokol kesehatan adalah positif sebanyak 25 responden (62,5%). Perilaku wanita hamil dalam melakukan ANC saat pandemi COVID-19 hampir seimbang antara perilaku positif dan perilaku negatif sehingga penting bagi ibu hamil untuk semakin sadar dalam menentukan perilaku yang baik selama hamil sehingga mampu menjalani kehamilan dengan baik, bersalin dengan selamat dan melahirkan bayi yang sehat.
Duality Pairs and Homomorphisms to Oriented and Unoriented Cycles
Authors: Guzmán-Pro Santiago , Hernández-Cruz César 
Published: July 2021

In the homomorphism order of digraphs, a duality pair is an ordered pair of digraphs $(G,H)$ such that for any digraph, $D$, $G\to D$ if and only if $D\not \to H$. The directed path on $k+1$ vertices together with the transitive tournament on $k$ vertices is a classic example of a duality pair.
In this work, for every undirected cycle $C$ we find an orientation $C_D$ and an oriented path $P_C$, such that $(P_C,C_D)$ is a duality pair. As a consequence we obtain that there is a finite set, $F_C$, such that an undirected graph is homomorphic to $C$, if and only if it admits an $F_C$-free orientation. As a byproduct of the proposed duality pairs, we show that if $T$ is an oriented tree of height at most $3$, one can choose a dual of $T$ of linear size with respect to the size of $T$.
A IDENTIDADE DO PROFESSOR: HERÓI OU REFÉM DO SEU TEMPO?
Authors: França de Avelar Amélia 
Published: July 2021

O objetivo deste artigo é discutir a construção da identidade docente ressaltando o papel do professor diante de uma melhor ualidade de ensino. Inicialmente aborda-se a construção da identidade docente como um processo contínuo e dinâmico. Num egundo momento reflete sobre a formação docente destacando que a mesma não se estabelece por meio de acumulação de cursos u técnicas e por fim faz-se necessário destacar os desafios que dificultam o trabalho docente diante da constante transformação da ociedade atual. Trata-se de uma pesquisa bibliográfica fundamentada nos estudos de Carlos Marcelo, Nóvoa, Pimenta, Libâneo e as eituras de diferentes artigos sobre a formação e a construção da identidade do professor no Brasil. Essa pesquisa norteia-se pela busca de resposta das seguintes indagações: Qual é na atualidade da educação brasileira os desafios que comprometem a dentidade docente e a qual a importância da transformação e reconstrução do perfil docente em prol da excelência no ensino?
TKS X: Confirmation of TOI-1444b and a Comparative Analysis of the Ultra-short-period Planets with Hot Neptunes
Authors: Dai Fei , Howard Andrew W. , Batalha Natalie M. , Beard Corey , Behmard Aida , Blunt Sarah , Brinkman Casey L. , Chontos Ashley , Crossfield Ian J. M. , Dalba Paul A. , Dressing Courtney , Fulton Benjamin , Giacalone Steven , Hill Michelle L. , Huber Daniel , Isaacson Howard , Kane Stephen R. , Lubin Jack , Mayo Andrew , Močnik Teo , Akana Murphy Joseph M. , Petigura Erik A. , Rice Malena , Robertson Paul , Rosenthal Lee , Roy Arpita , Rubenzahl Ryan A. , Weiss Lauren M. , Zandt Judah Van , Beichman Charles , Ciardi David , Collins Karen A. , Gonzales Erica , Howell Steve B. , Matson Rachel A. , Matthews Elisabeth C. , Schlieder Joshua E. , Schwarz Richard P. , Ricker George R. , Vanderspek Roland , Latham David W. , Seager Sara , Winn Joshua N. , Jenkins Jon M. , Caldwell Douglas A. , Colon Knicole D. , Dragomir Diana , Lund Michael B. , McLean Brian , Rudat Alexander , Shporer Avi 
Published: July 2021

Abstract
We report the discovery of TOI-1444b, a 1.4 R
⊕ super-Earth on a 0.47 day orbit around a Sun-like star discovered by TESS. Precise radial velocities from Keck/HIRES confirmed the planet and constrained the mass to be 3.87 ± 0.71M
⊕. The RV data set also indicates a possible nontransiting, 16 day planet (11.8 ± 2.9M
⊕). We report a tentative detection of phase-curve variation and a secondary eclipse of TOI-1444b in the TESS bandpass. TOI-1444b joins the growing sample of 17 ultra-short-period planets (USPs) with well-measured masses and sizes, most of which are compatible with an Earth-like composition. We take this opportunity to examine the expanding sample of ultra-short-period planets (<2R
⊕) and contrast them with the newly discovered sub-day ultrahot Neptunes (>3R
⊕, >2000F
⊕ TOI-849 b, LTT9779 b, and K2-100). We find that (1) USPs have predominately Earth-like compositions with inferred iron core mass fractions of 0.32 ± 0.04 and have masses below the threshold of runaway accretion (∼10M
⊕), while ultrahot Neptunes are above the threshold and have H/He or other volatile envelopes. (2) USPs are almost always found in multi-planet systems consistent with a secular interaction formation scenario; ultrahot Neptunes (P
orb ≲1 day) tend to be “lonely,” similar to longer-period hot Neptunes (P
orb1–10 days) and hot Jupiters. (3) USPs occur around solar-metallicity stars while hot Neptunes prefer higher metallicity hosts. (4) In all these respects, ultrahot Neptunes show more resemblance to hot Jupiters than the smaller USP planets, although ultrahot Neptunes are rarer than both USPs and hot Jupiters by 1–2 orders of magnitude.