bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the Influence of the Duration of Bisphosphonate Intake on the Outcome of Bisphosphonate-associated Osteonecrosis of the Jaws Treatment Using Statistical Method Logistic Regression
Authors: Ilieva Boryana , Prodanova Krasimira , Svechtarov Vassil 
Published: December 2024

Bisphosphonates are a group of drugs that are widely used in the treatment of osteoclast-mediated diseases related to bone loss. Since 2003 the problem of bisphosphonate-associated osteonecrosis of the jaws (BAONJ) has been raised, and many authors have published the cases they have observed. BAONJ is a multifactorial disease, and the risk factors for the development of the disease can be divided into those related to bisphosphonate therapy, local risk factors, demographic and systemic factors, genetic factors and preventive factors.
The aim of the present study is to determine the effect of the duration of bisphosphonate intake on the outcome of bisphosphonate-associated osteonecrosis of the jaws (BAONJ) treatment using the statistical method one-dimensional logistic regression which is from the direction of regression analysis. In the present study we included 44 patients diagnosed with Bisphosphonate-associated osteonecrosis of the jaw (BAONJ). For each patient included in the study, information on the anamnesis, general and local status and results of clinical and paraclinical studies is recorded in an individual card.
Our study shows that with the increase of the duration of BF intake, the likelihood of disease progression also increases, found in the examination of the patient on the first and on the sixth month after the treatment of BAONJ. Therefore, we can conclude that the factor duration of BF intake can be used as a predictor of the outcome of BAONJ treatment, and with increasing of its value, the likelihood of disease progression increases. Furthermore, we can suggest that the duration of bisphosphonate intake is an important
The Ameliorative Effects of AT2 Receptor Activation with the Hexapeptide Novokinin on Streptozotocin-induced Model of Alzheimer's Disease in SHR
Authors: Chelmis Filippos , Sorotou Iliana , Pakataridis Paraskevas , Pechlivanova Daniela 
Published: December 2024

Alzheimer's disease (AD), a form of dementia, presents a global concern. This study investigates the connection between hypertension and AD and the effects of the peptide novokinin (NVK), an AT2 receptor agonist in spontaneously hypertensive rats (SHRs). The brain's renin-angiotensin system (RAS) influences cognitive and emotional processes, suggesting potential intersections with AD. Streptozotocin (STZ), administered intracerebroventricularly (ICV), is used as a model of late-onset Alzheimer's disease. This model reveals a memory impairment associated with an insulin-resistant brain state, marked by neuroinflammatory processes contributing to cognitive deficits, oxidative stress, and reduced cerebral energy metabolism. NVK is an angiotensin AT2 receptor agonist, studied for its potential neuroprotective role. Female SHRs were used to investigate the effects of STZ-ICV (twice) and chronic NVK-ICV. NVK was administered for 14 days ICV using osmotic minipumps (ALZET®). The control group exhibited strain-typical increased exploratory activity, reduced anxiety in new environments, and impaired spatial memory, as expected for SHRs. The STZ-ICV negative control group showed signs of impaired memory and object recognition. In the `Open Field’ test, STZ-treated groups with and without NVK-ICV displayed heightened exploratory behaviour. Data from the `Elevated plus maze' test showed decreased anxiety in the STZ-ICV group while combining STZ and NVK normalized the anxiety behaviour. In the `T-maze' test, STZ-ICV-treated rats made fewer correct decisions. The STZ+NVK group exhibited enhanced spatial memory and improved anxiety-like behaviour in novel environments, potentially attributable to the proposed neuroprotective effects of NVK. These findings emphasize the association of RAS in the progression of AD and the potential protective role of the brain's AT2 receptors in this type of dementia.
The Hidden Potential of Polysilsesquioxane for High‐k: Analysis of the Origin of its Dielectric Nature and Practical Low‐Voltage‐Operating Applications beyond the Unit Device
Authors: Ye Heqing , Kwon Hyeok‐jin , Shin Su Cheol , Lee Hwi‐young , Park Young Ho , Tang Xiaowu , Wang Ruxian , Lee Kanghyuck , Hong Jisu , Li Zhijun , Jeong Wonkyo , Kim Jiyeong , Park Chan Eon , Lee Jihoon , An Tae Kyu , In Insik , Kim Se Hyun 
Published: October 2021

AbstractLow‐voltage‐operating high‐performance organic field‐effect transistors (OFETs) are regarded as the building blocks of analog and digital integrated circuits for next‐generation electronics. To fulfill this, such an OFET must have high‐dielectric constant (k) characteristics for increasing the capacitance values to make enough of a field‐effect charge, a hydrophobic surface that does not cause charge trapping, and a low leakage current property to guarantee operating stability. This study demonstrates a new strategy to induce high‐k characteristics (>8) with durable polysilsesquioxane (PSQ)‐based dielectrics. This strategy involves realizing a dipolar side‐chain reorientation under an electric field and its applications to low‐voltage‐driving OFETs showing high field‐effect mobility levels as high as 27 cm2 V–1 s–1. Different PSQs are characterized, and the differences in their characteristics lead to distinct polarization phenomena, resulting in different hysteresis behaviors during device operation. The printed unit devices can also be fabricated on flexible platforms and integrated devices through these materials and show robust switching or memory performances under low‐voltage‐operation conditions. Therefore, this facile but powerful synthesis strategy for high‐k PSQ dielectrics can pave a new path for the production of practical printable high‐k dielectrics for organic electronics and hence realize next‐generation integrated electronics.
Kill&Repel Coatings: The Marriage of Antifouling and Bactericidal Properties to Mitigate and Treat Wound Infections
Authors: Garay‐Sarmiento Manuela , Witzdam Lena , Vorobii Mariia , Simons Christian , Herrmann Niklas , de los Santos Pereira Andres , Heine Elisabeth , El‐Awaad Islam , Lütticken Rudolf , Jakob Felix , Schwaneberg Ulrich , Rodriguez‐Emmenegger Cesar 
Published: October 2021

AbstractWound infections originate when exogenous or endogenous bacterial pathogens can circumvent the barrier of the wound dressing and invade the wound bed. Bacterial colonization causes inflammation, stalls the healing process, and carries the risk of dissemination to other tissues. In addition, current antimicrobial dressings fail to resolve an infection once it has been established because debris of the killed bacteria rapidly accumulates on their surface and hampers the antimicrobial action. Faced with this challenge, hybrid synthetic‐natural water‐soluble macromolecules are designed that self‐assemble onto the surface of dressings to generate an antifouling brush functionalized with endolysin, a bactericidal enzyme that poses no harm for eukaryotic cells. The simultaneous action of the brush and the enzyme not only prevents the colonization of the dressing, but also enables the coating to kill planktonic bacteria with even higher efficiency than the free enzyme. Remarkably, the Kill&Repel coating could completely eradicate bacteria in a simulated infection without allowing the adhesion of residues on the surface. Thus, this strategy opens a revolutionary approach for protecting and treating an infected wound in a safer and more efficient manner.
Simple Nonfused‐Ring Electron Acceptors with Noncovalently Conformational Locks for Low‐Cost and High‐Performance Organic Solar Cells Enabled by End‐Group Engineering
Authors: Li Congqi , Zhang Xin , Yu Na , Gu Xiaobin , Qin Linqing , Wei Yanan , Liu Xingzheng , Zhang Jianqi , Wei Zhixiang , Tang Zheng , Shi Qinqin , Huang Hui 
Published: October 2021

AbstractThe rapid advance of fused‐ring electron acceptors (FREAs) has greatly promoted the leap‐forward development of organic solar cells (OSCs). However, the synthetic complexity of FREAs may be detrimental for future commercial applications. Recently, nonfused‐ring electron acceptors (NREAs) have been developed to be a promising candidate to maintain a rational balance between cost and performance, of which the cores are composed of simple fused rings (NREAs‐I) or nonfused rings (NREAs‐II). Moreover, “noncovalently conformational locks”, are used as an effective strategy to enhance the rigidity and planarity of NREAs and improve device performance. Herein, a novel series of NREAs‐II (PhO4T‐1, PhO4T‐2, and PhO4T‐3) is constructed as a valuable platform for exploring the impact of the end group engineering on optoelectronic properties, intermolecular packing behaviors, and device performance. As a result, a high power conversion efficiency of 13.76% is achieved for PhO4T‐3 based OSCs, which is much higher than those of the PhO4T‐1 and PhO4T‐2‐based devices. Compared with several representative FREAs, PhO4T‐3 possesses the highest figure‐of‐merit value of 133.45 based on a cost‐efficiency evaluation. This work demonstrates that the simple‐structured NREAs‐II are promising candidates for low‐cost and high‐performance OSCs.
Er‐Activated Hybridized Glass Fiber for Laser and Sensor in the Extended Wavebands
Authors: Huang Xiaoyi , Cheng Huihui , Luo Wei , Zhang Weida , Jiang Min , Yang Changsheng , Yu Tao , Cai Zhiping , Xu Zuowei , Shu Xuewen , Yang Zhongmin , Qiu Jianrong , Zhou Shifeng 
Published: October 2021

AbstractEr‐activated fiber lasers are critical for many significant applications, including fiber communication, gas sensing, lidar and military. Although the design of suitable fiber materials has improved the performance of Er‐activated fiber lasers, extension of their operation wavebands still remains a significant challenge. Here, a compact all‐fiber laser is proposed and demonstrated, which can support lasing beyond 1630 nm, based on an Er‐activated hybridized glass fiber. The collaborative theoretical analysis and experimental characterization indicate that various distinct structure units can form in the hybridized fiber. This leads to the notable inhomogeneous spectral broadening. By using this hybridized fiber, a tunable fiber laser device is constructed and the wavelength can be rationally tuned in the range from 1609 to 1631 nm by mechanically stretching the fiber Bragg gratings (FBGs) manufactured by the point‐by‐point femtosecond laser inscription. Furthermore, a new fiber sensor system based on this seldom exploration waveband is built and efficient ethylene detection is demonstrated. The results highlight that rational hybridization mediated short‐ and medium‐structure modification strategy, demonstrated here in Er‐activated fiber laser, can be extended to other rare‐earth glass fiber systems for the exploration of fiber devices at new wavebands.
Unveiling the Reversibility and Stability Origin of the Aqueous V2O5–Zn Batteries with a ZnCl2 “Water‐in‐Salt” Electrolyte
Authors: Tang Xiaoyu , Wang Pan , Bai Miao , Wang Zhiqiao , Wang Helin , Zhang Min , Ma Yue 
Published: October 2021

AbstractAqueous V2O5–Zn batteries, an alternative chemistry format that is inherently safer to operate than lithium‐based batteries, illuminates the low‐cost deployment of the stationary energy storage devices. However, the cathode structure collapse caused by H2O co‐insertion in aqueous solution dramatically deteriorates the electrochemical performance and hampers the operation reliability of V2O5–Zn batteries. The real‐time phase tracking and the density functional theory (DFT) calculation prove the high energy barrier that inhibits the Zn2+ diffusion into the bulk V2O5, instead the ZnCl2 “water‐in‐salt electrolyte” (WiSE) can enable the dominant proton insertion with negligible lattice strain or particle fragment. Thus, ZnCl2 WiSE enables the enhanced reversibility and extended shelf life of the V2O5–Zn battery upon the high temperature storage. The improved electrochemical performance also benefits by the inhibition of vanadium cation dissolution, enlarged voltage window, as well as the suppression of the Zn dendrite protrusion. This study comprehensively elucidates the pivotal role of a concentrated ZnCl2 electrolyte to stabilize the aqueous batteries at both the static storage and dynamic operation scenarios.
Patching interpretable And‐Or‐Graph knowledge representation using augmented reality
Authors: Liu Hangxin , Zhu Yixin , Zhu Song‐Chun 
Published: October 2021

AbstractWe present a novel augmented reality (AR) interface to provide effective means to diagnose a robot's erroneous behaviors, endow it with new skills, and patch its knowledge structure represented by an And‐Or‐Graph (AOG). Specifically, an AOG representation of opening medicine bottles is learned from human demonstration and yields a hierarchical structure that captures the spatiotemporal compositional nature of the given task, which is highly interpretable for the users. Through a series of psychological experiments, we demonstrate that the explanations of a robotic system, inherited from and produced by the AOG, can better foster human trust compared to other forms of explanations. Moreover, by visualizing the knowledge structure and robot states, the AR interface allows human users to intuitively understand what the robot knows, supervise the robot's task planner, and interactively teach the robot with new actions. Together, users can quickly identify the reasons for failures and conveniently patch the current knowledge structure to prevent future errors. This capability demonstrates the interpretability of our knowledge representation and the new forms of interactions afforded by the proposed AR interface.
Sterically enhanced 2‐iminopyridylpalladium chlorides as recyclable ppm‐palladium catalyst for Suzuki–Miyaura coupling in aqueous solution
Authors: Lin Wenhua , Zhang Liping , Ma Yanping , Liang Tongling , Sun Wen‐Hua 
Published: October 2021

AbstractSterically hindered 2‐iminopyridine derivatives and their palladium chlorides complexes are designed and prepared, which efficiently promote the Suzuki–Miyaura coupling (SMC) reaction in aqueous solution. Besides the good to excellent yields and broad substrate scope, these catalysts can be reused for at least four new batches of the substrates. Spontaneous separation of coupling products in the aqueous reaction medium is the additional striking feature of this catalytic process. Furthermore, catalytic performance of palladium complexes bearing the azo‐bridged phenyl groups was greatly influenced by the UV irradiation due to the cis/trans photoisomerization of azo unit of the catalysts. In conclusion, titled palladium complexes provide a green, sustainable, cost‐effective, and convenient process to synthesize SMC products at multi‐gram‐scale reaction.
Photocatalytic degradation of methylene blue dye using poly(3‐hydroxybutyrate)/poly(ethylene glycol)/titanite films and membranes
Authors: Domínguez‐Díaz Maraolina , Cortés‐Hernández Dora A. , De la O‐Baquera Edgar , Dávila Medina Miriam D. 
Published: October 2021

AbstractIn this work, novel poly(3‐hydroxybutyrate) (PHB)/poly(ethylene glycol) (PEG)/titanite (CaTiSiO5) composites in the form of films and membranes are used for the photocatalytic degradation of methylene blue (MB) in aqueous solution. Films and membranes are prepared from PHB and PEG with either 80 or 93 mol% of titanite. For comparison purposes, titanite powder, films, and membranes of PHB and PEG with no titanite added, are also analyzed. To study the behavior of the materials, X‐ray diffraction, luminescence, field emission scanning electron microscopy, and Raman spectroscopy, are used. Additionally, contact angle was measured by the sessile drop technique. Materials are placed in a beaker containing the MB aqueous solution under constant stirring and exposed to UV light for 12 h. With respect to the initial concentration (C0), the relative MB concentration (C/C0) is measured every hour employing UV–visible spectroscopy. The obtained results showed that by using 0.010 g of titanite powder, approximately 30% of the MB is degraded after 12 h of UV irradiation. The highest MB degradation is obtained with 0.320 g of the polymer/ceramic membrane (0.310 g of polymers and 0.010 g of titanite), where approximately 90% of MB is degraded.
Evaluating the interrelations between the autism polygenic score and psychiatric family history in risk for autism
Authors: Schendel Diana , Munk Laursen Thomas , Albiñana Clara , Vilhjalmsson Bjarni , Ladd‐Acosta Christine , Fallin Margaret Danielle , Benke Kelly , Lee Brian , Grove Jakob , Kalkbrenner Amy , Ejlskov Linda , Hougaard David , Bybjerg‐Grauholm Jonas , Bækvad‐Hansen Marie , Børglum Anders D. , Werge Thomas , Nordentoft Merete , Mortensen Preben Bo , Agerbo Esben 
Published: October 2021

AbstractPsychiatric family history or a high autism polygenic risk score (PRS) have been separately linked to autism spectrum disorder (ASD) risk. The study aimed to simultaneously consider psychiatric family history and individual autism genetic liability (PRS) in autism risk. We performed a case–control study of all Denmark singleton births, May 1981–December 2005, in Denmark at their first birthday and a known mother. Cases were diagnosed with ASD before 2013 and controls comprised a random sample of 30,000 births without ASD, excluding persons with non‐Denmark‐born parents, missing ASD PRS, non‐European ancestry. Adjusted odds ratios (aOR) were estimated for ASD by PRS decile and by psychiatric history in parents or full siblings (8 mutually‐exclusive categories) using logistic regression. Adjusted ASD PRS z‐score least‐squares means were estimated by psychiatric family history category. ASD risk (11,339 ASD cases; 20,175 controls) from ASD PRS was not substantially altered after accounting for psychiatric family history (e.g., ASD PRS 10th decile aOR: 2.35 (95% CI 2.11–2.63) before vs 2.11 (95% CI 1.91–2.40) after adjustment) nor from psychiatric family history after accounting for ASD PRS (e.g., ASD family history aOR: 6.73 (95% CI 5.89–7.68) before vs 6.32 (95% CI 5.53–7.22) after adjustment). ASD risk from ASD PRS varied slightly by psychiatric family history. While ASD risk from psychiatric family history was not accounted for by ASD PRS and vice versa, risk overlap between the two factors will likely increase as measures of genetic risk improve. The two factors are best viewed as complementary measures of family‐based autism risk.Lay SummaryAutism risk from a history of mental disorders in the immediate family was not explained by a measure of individual genetic risk (autism polygenic risk score) and vice versa. That is, genetic risk did not appear to overlap family history risk. As genetic measures for autism improve then the overlap in autism risk from family history versus genetic factors will likely increase, but further study may be needed to fully determine the components of risk and how they are inter‐related between these key family factors. Meanwhile, the two factors may be best viewed as complementary measures of autism family‐based risk.
DIN EN 1998‐1/NA‐2021 im Kontext der deutschen und europäischen Normenentwicklung
Authors: Fehling Ekkehard , Schwarz Jochen 
Published: October 2021

AbstractDer Beitrag gibt eine Übersicht zu den Grundlagenuntersuchungen, z. T. kontrovers diskutierten Fragestellungen und Meilensteinen, die in langjähriger Tätigkeit des Normenausschusses Bauwesen NA 005‐51‐06 „Erdbeben, Sonderfragen“ zur Erstellung des Nationalen Anhangs DIN EN 1998‐1/NA‐2021 geführt bzw. beigetragen haben. Entsprechende Forschungsarbeiten werden in einer Zusammenschau gewürdigt. Der NA bezieht sich auf die 1. Generation des Eurocode 8; Arbeiten der 2. Generation lassen erkennen, in welche Richtung sich die Normung im Hinblick auf die Auslegungsziele und Nachweismethoden entwickeln wird. Im Ausblick kann konstatiert werden, dass der NA wesentliche Neuerungen bereits aufgreift bzw. implementiert. Aus der Rückschau der Obleute wird verdeutlicht, welche Entscheidungszwänge im Spannungsfeld zwischen notwendigem Sicherheitsanspruch und vermeintlichen ökonomischen Restriktionen bestehen bzw. dass die Erdbeben‐Baunormung bei den national zu treffenden Risikoentscheidungen keine einfachen Lösungen bereithält. Dargestellt wird, welche Veränderungen am Maßstab der europäischen Normenentwicklung eingeführt wurden. Sie betreffen neben den Gefährdungs‐ und Einwirkungskenngrößen insbesondere die für die national dominierende Mauerwerksbauweise iniitierten Untersuchungen, um es dem praktisch tätigen Ingenieur zu ermöglichen, ein breites Spektrum an vereinfachten Regeln anzuwenden und dazu die erforderlichen Entscheidungs‐ und Berechnungshilfen zur Verfügung zu stellen.
Lung metastasis after pneumonectomy: Is there a place for surgery?
Authors: Usenko Oleksandr , Sydiuk Andrii , Klimas Andrii , Sydiuk Olena , Savenko Georgii , Teslia Oleh 
Published: October 2021

AbstractResection of the contralateral lung after primary total pneumonectomy is a real surgical option for patients with secondary lung disease.
Rectal irrigation as rescue therapy for refractory and severe hemorrhagic radiation proctitis: A case report
Authors: Pattarajierapan Sukit , Amornwichet Napapat , Khomvilai Supakij 
Published: October 2021

AbstractRectal irrigation may be considered in refractory and severe hematochezia from chronic radiation proctitis before performing other invasive treatments. It prevents superimposed infection and effectively reduces bleeding.
EDTA‐dependent pseudo thrombocytopenia mimicking dengue fever‐associated persistent thrombocytopenia: A case report
Authors: Shrestha Gentle Sunder , Basnet Babin , Nepal Gaurav , Lamichhane Rajan , Gaire Prabin , Shrestha Rayana , Thapalia Sabin 
Published: October 2021

AbstractNo hemorrhagic manifestations, presence of platelet clumps on the peripheral blood smear, normal manual count, and normal autoanalyzer count after collecting blood in citrate vial help confirm the diagnosis of EDTA‐dependent thrombocytopenia.