bluuebunny/crossref_metadata_2025_split huggingface dataset:
Al-Maʿarrī’s Anxious Menagerie: The Epistle of the Horse and the Mule
Authors: Blankinship Kevin 
Published: July 2021

Abstract
Around the year 411/1021, blind author and controversial freethinker Abū l-ʿAlāʾ al-Maʿarrī (449/1057) wrote Risālat al-ṣāhil wa-l-shāḥij (The Epistle of the Horse and the Mule), a meandering prose work populated by animal characters who talk about Syrian society on the eve of the crusades. The story exudes a brand of fictionality, namely creative literary exaggeration designed to call forth mental pictures, that sets it apart from other animal texts due to the overwhelming ambiguity it creates. The animal characters suffer existential anxiety when, for instance, they realize that concepts like genus (jins) and species (nawʿ) turn out to be fuzzier than they thought, thereby calling into question whether any species—be it biological or linguistic—is a stable class. Animal ontology gets further confused by just-so stories about hybrids and crossbreeds, and by terms for philosophical contingency that question whether talking animals even exist—this is not just a story that did not happen, but a story that cannot happen except in the imagination. On the other hand, those same philosophical terms may yet affirm that speaking animals could exist, and that they have value in themselves, by hinting at their place in a cosmic order that radiates the goodness of its Source.
Robust atmospheric river response to global warming in idealized and comprehensive climate models
Authors: Zhang Pengfei , Chen Gang , Ma Weiming , Ming Yi , Wu Zheng 
Published: July 2021

AbstractAtmospheric rivers (ARs), narrow intense moisture transport, account for much of the poleward moisture transport in midlatitudes. While studies have characterized AR features and the associated hydrological impacts in a warming climate in observations and comprehensive climate models, the fundamental dynamics for changes in AR statistics (e.g., frequency, length, width) are not well understood. Here we investigate AR response to global warming with a combination of idealized and comprehensive climate models. To that end, we developed an idealized atmospheric GCM with Earth-like global circulation and hydrological cycle, in which water vapor and clouds are modeled as passive tracers with simple cloud microphysics and precipitation processes. Despite the simplicity of model physics, it reasonably reproduces observed dynamical structures for individual ARs, statistical characteristics of ARs, and spatial distributions of AR climatology. Under climate warming, the idealized model produces robust AR changes similar to CESM large ensemble simulations under RCP8.5, including AR size expansion, intensified landfall moisture transport, and an increased AR frequency, corroborating previously reported AR changes under global warming by climate models. In addition, the latitude of AR frequency maximum shifts poleward with climate warming. Further analysis suggests the thermodynamic effect (i.e., an increase in water vapor) dominates the AR statistics and frequency changes while both the dynamic and thermodynamic effects contribute to the AR poleward shift. These results demonstrate that AR changes in a warming climate can be understood as passive water vapor and cloud tracers regulated by large-scale atmospheric circulation, whereas convection and latent heat feedback are of secondary importance.
Progressive Pulse Compression: A Novel Technique for Blind Range Recovery for Solid-State Radars
Authors: Salazar Aquino Cesar M. , Cheong Boonleng , Palmer Robert D. 
Published: July 2021

AbstractIn this paper, a novel technique is proposed to mitigate the so-called blind range on radars that use pulse compression. It is well known that the blind range is caused by the strong leak-through into the receiver during the transmission cycle. The proposed technique is called progressive pulse compression (PPC) and is based on partial decoding. PPC uses a portion of the uncontaminated received signal in conjunction with pulse compression to estimate the echoes from the incomplete signal. The technique does not require the use of a fill pulse or any hardware modifications. PPC can be divided into three steps. The fist step is to discard all the received signals during the transmit cycle and apply a smooth taper for continuous transition from zero to one. The second step is to perform the pulse compression using matched filter. The combination of these two steps is equivalent to performing pulse compression using a progressively changing template to partially extract the uncontaminated received signal for compression. The third step is to compensate for the progressively changing template so that proper reflectivity values can be recovered. This technique has been tested on the PX-1000 and will be implemented on PX-10k in the near future. These two radars are designed and operated by the Advanced Radar Research Center at the University of Oklahoma and are both X-band software-defined solid-state systems. The results presented in this paper are collected using the PX-1000 radar.
The impact of parental mental health problems on the educational outcomes of their offspring: Findings from the Raine Study
Authors: Ayano Getinet , Lin Ashleigh , Dachew Berihun Assefa , Tait Robert , Betts Kim , Alati Rosa 
Published: July 2021

Objectives: There is limited evidence on the impact of parental mental health problems on offspring’s educational outcomes. We investigated the impact of maternal anxiety and depressive symptoms, as well as paternal emotional problems on the educational outcomes of their adolescent and young adult offspring. Methods: We used data from a longitudinal birth cohort recruited between 1989 and 1991 in Australia (the Raine Study). The Depression, Anxiety and Stress Scale was used to assess maternal depressive and anxiety symptoms, and a self-reported question was used to measure paternal mental health problems. Both were assessed when the offspring was aged 10 years. Outcomes included offspring’s self-reported education attainment—not completing year 10 at age 17, not attending tertiary education at ages 17 and 22 and primary caregiver’s reports of offspring’s academic performance at age 17. Results: A total of 1033, 1307 and 1364 parent–offspring pairs were included in the final analysis exploring the association between parental mental health problems and offspring’s academic performance at school, completing year 10 and attending tertiary education, respectively. After adjusting for potential confounders, the offspring of mothers with anxiety symptoms were 3.42 times more likely than the offspring of mothers without anxiety symptoms to have poor or below-average academic performance (odds ratio = 3.42; 95% confidence interval = [1.31, 8.92]) and more than 2 times more likely to not attend tertiary education (odds ratio = 2.55; 95% confidence interval = [1.10, 5.5.88]) and not to have completed year 10 (odds ratio = 2.13; 95% confidence interval = [1.04, 4.33]). We found no significant associations between maternal depressive symptoms or paternal emotional problems and offspring educational attainment. Conclusion: Maternal anxiety symptoms, but not depression and paternal emotional problems, are associated with poor educational attainment and achievement in adolescent offspring. The findings highlight that efforts to improve the outcomes of offspring of mothers with anxiety could focus on educational attainment.
Two-dimensional-Wilkins and real-time transesophageal three-dimensional scoring systems: Which one is preferred to mitral valve morphological assessment?
Authors: Toufan Mehrnoush , Jabbary Zahra , aghdam Naser Khezerlou 
Published: July 2021

Background To quantify valvular morphological assessment, some two-dimensional (2D) and three-dimensional (3D) scoring systems have been developed to target the patients for balloon mitral valvuloplasty; however, each scoring system has some potential limitations. To achieve the best scoring system with the most features and the least restrictions, it is necessary to check the degree of overlap of these systems. Also the factors related to the accuracy of these systems should be studied. We aimed to determine the correlation between the 2D Wilkins and real-time transesophageal three-dimensional (RT3D-TEE) scoring systems. Methods This cross-sectional study was performed on 156 patients with moderate to severe mitral stenosis who were candidates for percutaneous balloon valvuloplasty. To morphologic assessment of mitral valve, patients were examined by 2D-transthoracic echocardiography and RT3D-TEE techniques on the same day. Results A strong association was found between total Wilkins and total RT3D-TEE scores (r = 0.809, p < 0.001). The mean mitral valve area assessed by the 2D and 3D was 1.07 ± 0.25 and 1.03 ± 0.26, respectively, indicating a mean difference of 0.037 cm2 (p = 0.001). We found a strong correlation between the values of mitral valve area assessed by 2D and 3D techniques (r = 0.846, p < 0.001). Conclusion There is a high correlation between the two scoring systems in terms of evaluating dominant morphological features. Partially, mitral valve area overestimation in the 2D-transthoracic echocardiography and its inability to assess commissural involvement as well as its dependence on patient age were exceptions in this study.
Augmented Inverse Probability Weighting and the Double Robustness Property
Authors: Kurz Christoph F. 
Published: July 2021

This article discusses the augmented inverse propensity weighted (AIPW) estimator as an estimator for average treatment effects. The AIPW combines both the properties of the regression-based estimator and the inverse probability weighted (IPW) estimator and is therefore a “doubly robust” method in that it requires only either the propensity or outcome model to be correctly specified but not both. Even though this estimator has been known for years, it is rarely used in practice. After explaining the estimator and proving the double robustness property, I conduct a simulation study to compare the AIPW efficiency with IPW and regression under different scenarios of misspecification. In 2 real-world examples, I provide a step-by-step guide on implementing the AIPW estimator in practice. I show that it is an easily usable method that extends the IPW to reduce variability and improve estimation accuracy. [Box: see text]
Kidney transplantation outcomes in lupus nephritis: A 37-year single-center experience from Latin America
Authors: Rodelo Joaquín , González Luis Alonso , Ustáriz José , Matera Silvia , Pérez Keylis , Ramírez Zoraida , Arias Luis Fernando , García Álvaro , Arbeláez Mario , Henao Jorge 
Published: July 2021

Objective We assessed patient and graft outcomes and prognostic factors in kidney transplantation in patients with end-stage kidney disease (ESKD) secondary to lupus nephritis (LN) undergoing kidney transplantation from August 1977 to December 2014 in a Latin American single center. Methods The primary endpoint was patient survival, and the secondary endpoints were death-censored graft survival for the first renal transplant and the rate of recurrent LN (RLN). Kaplan–Meier method was used for survival analysis. Factors predicting patient and death-censored graft survivals were examined by Cox proportional-hazards regression analyses. Results 185 patients were retrospectively evaluated. Patient survival rates were 88% at one year, 82% at three years, 78% at five years, and 67% at ten years. Death-censored graft survival for the first renal transplant was 93% at one year, 89% at three years, 87% at five years, and 80% at ten years. RLN was diagnosed in 2 patients (1.08%), but no graft was lost because of RLN. Thirty-nine (21.1%) patients died, and 65 (35.1%) patients experienced graft loss during the follow-up. By multivariable analyses, older recipient age and 1-month posttransplantation eGFR <45 ml/min/1.73m2 were associated with lower patient survival and an increased risk of graft loss, while induction immunosuppressive therapy exerted a protective effect on patients’ survival. In the subgroup of patients in whom disease activity was measured at the time of transplantation, a higher SLEDAI score was also associated with lower patient survival and an increased risk of graft loss. Conclusion In a mostly Mestizo population, kidney transplantation is an excellent therapeutic alternative in LN patients with ESKD. Older recipient age, an eGFR <45 ml/min/1.73m2 at one month posttransplantation, and disease activity at the time of transplantation are predictive of a lower patient and death-censored graft survival, while induction immunosuppressive therapy has a protective effect on patient survival. RLN is rare and does not influence the risk of graft loss.
Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study
Authors: Diao Junrong , Gao Ge , Zhang Yunshan , Wang Xinyan , Zhang Yinfeng , Han Ying , Du Aijun , Luo Haining 
Published: July 2021

Abstract
Background
Caesarean section rates are rising worldwide. One adverse effect of caesarean section reported in some studies is an increased risk of subfertility. Only a few studies have assessed the relationship between the previous mode of delivery and in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) reproductive outcomes. In this study, we primarily investigated the impact of a history of caesarean section with or without defects on IVF/ICSI-ET outcomes compared to a vaginal delivery history.

Methods
This retrospective study included 834 women who had a IVF or ICSI treatment at our centre between 2015 and 2019 with a delivery history. In total, 401 women with a previous vaginal delivery (VD) were assigned to the VD group, and 433 women with a history of delivery by caesarean section were included, among whom 359 had a caesarean scar (CS) without a defect and were assigned to the CS group and 74 had a caesarean section defect (CSD) and were assigned to the CSD group. Baseline characteristics of the three groups were compared and analysed. Binary logistic regression analyses were performed to explore the association between clinical outcomes and different delivery modes.

Results
There were no significant differences in the live birth rate, biochemical pregnancy rate, clinical pregnancy rate, mean implantation rate or abnormal pregnancy rate between the CS and VD groups However, the live birth rate and mean implantation rate in the CSD group were significantly lower than those in the VD group (21.6 vs 36.4%, adjusted OR 0.50 [0.27–0.9]; 0.25 ± 0.39 vs 0.35 ± 0.41, adjusted OR 0.90 [0.81–0.99]). Among women aged ≤ 35 years, the subgroup analyses showed that the live birth rate, biochemical pregnancy rate, clinical pregnancy rate, and mean implantation rate in the CSD group were all significantly lower than those in the VD group (21.4 vs 45.8%, adjusted OR 0.35[0.15 ~ 0.85]; 38.1 vs 59.8%, adjusted OR 0.52[0.24–0.82]; 31.0 vs 55.6%, adjusted OR 0.43[0.19–0.92]; 0.27 ± 0.43 vs 0.43 ± 0.43, adjusted OR 0.85[0.43 ± 0.43]). For women older than 35 years, there was no statistically significant difference in any pregnancy outcome among the three groups.

Conclusions
This study suggested that the existence of a CS without a defect does not decrease the live birth rate after IVF or ICSI compared with a previous VD. However, the presence of a CSD in women, especially young women (age ≤ 35 years), significantly impaired the chances of subsequent pregnancy.
Risk factors for venous thromboembolism in patients with diabetes undergoing joint arthroplasty
Authors: Deng Wei , Huo Lili , Yuan Qiang , Huang Deyong , Li Quan , Tian Wei 
Published: July 2021

Abstract
Background
Venous thromboembolism (VTE) is a significant complication after joint arthroplasty. Diabetes is related to a few changes in coagulation and fibrinolysis that may lead to thrombophilia. We aimed to investigate the incidence of postoperative VTE and associated risk factors among patients with diabetes undergoing total hip (THA) or total knee anthroplasty (TKA) in a single centre in China.

Methods
Patients with diabetes who underwent THA or TKA from January 2016 to December 2018 (n = 400) at Beijing Jishuitan Hospital were recruited in this study. Lower limb venous Doppler ultrasound was performed before and after surgery to confirm deep venous thrombosis (DVT). Computer tomography pulmonary angiography was done to confirm pulmonary embolism (PE) for those with new postoperative DVT and typical symptoms of PE. A multivariate logistic regression model was conducted to examine factors associated with the development of postoperative VTE.

Results
The overall incidence of postoperative VTE in patients with diabetes after THA or TKA was 46.8 % (187 out of 400). Among the 187 VTE patients, 7.5 % (14 out of 187) had proximal vein thrombosis and 92.5 % (173 out of 187) had distal vein thrombosis. No PE occurred. Female patients and patients undergoing TKA had higher incidence of postoperative VTE. Patients who developed postoperative VTE were older, and had higher levels of preoperative D-Dimer and Caprini score. A high level of preoperative D-dimer (OR = 2.11, 95 %CI = 1.35–3.30) and the surgery of TKA (OR = 2.29, 95 %CI = 1.29–4.01) significantly increased the risk of developing postoperative VTE. Postoperative initiation of concomitant mechanical prophylaxis and low molecular weight heparin (LMWH) was protective for postoperative VTE (OR = 0.56, 95 %CI = 0.37–0.86).

Conclusions
VTE is common in patients with diabetes undergoing joint arthroplasty. Patients undergoing TKA or with a high level of preoperative D-dimer are at a considerable risk of developing postoperative VTE. There may be a protective role of postoperative initiation of concomitant mechanical prophylaxis and LMWH for VTE.
Clinical and sociodemographic factors associated with late stage cervical cancer diagnosis in Botswana
Authors: Friebel-Klingner Tara M. , Luckett Rebecca , Bazzett-Matabele Lisa , Ralefala Tlotlo B. , Monare Barati , Nassali Mercy Nkuba , Ramogola-Masire Doreen , Bvochora Memory , Mitra Nandita , Wiebe Douglas , Rebbeck Timothy R. , McCarthy Anne Marie , Grover Surbhi 
Published: July 2021

Abstract
Background
Cervical cancer is the leading cause of female cancer mortality in Botswana with the majority of cervical cancer patients presenting with late-stage disease. The identification of factors associated with late-stage disease could reduce the cervical cancer burden. This study aims to identify potential patient level clinical and sociodemographic factors associated with a late-stage diagnosis of cervical cancer in Botswana in order to help inform future interventions at the community and individual levels to decrease cervical cancer morbidity and mortality.

Results
There were 984 women diagnosed with cervical cancer from January 2015 to March 2020 at two tertiary hospitals in Gaborone, Botswana. Four hundred forty women (44.7%) presented with late-stage cervical cancer, and 674 women (69.7%) were living with HIV. The mean age at diagnosis was 50.5 years. The association between late-stage (III/IV) cervical cancer at diagnosis and patient clinical and sociodemographic factors was evaluated using multivariable logistic regression with multiple imputation. Women who reported undergoing cervical cancer screening had lower odds of late-stage disease at diagnosis (OR: 0.63, 95% CI 0.47–0.84) compared to those who did not report screening. Women who had never been married had increased odds of late-stage disease at diagnosis (OR: 1.35, 95% CI 1.02–1.86) compared to women who had been married. Women with abnormal vaginal bleeding had higher odds of late-stage disease at diagnosis (OR: 2.32, 95% CI 1.70–3.16) compared to those without abnormal vaginal bleeding. HIV was not associated with a diagnosis of late-stage cervical cancer. Rural women who consulted a traditional healer had increased odds of late-stage disease at diagnosis compared to rural women who had never consulted a traditional healer (OR: 1.61, 95% CI 1.02–2.55).

Conclusion
Increasing education and awareness among women, regardless of their HIV status, and among providers, including traditional healers, about the benefits of cervical cancer screening and about the importance of seeking prompt medical care for abnormal vaginal bleeding, while also developing support systems for unmarried women, may help reduce cervical cancer morbidity and mortality in Botswana.
Clinical characteristics, gestational weight gain and pregnancy outcomes in women with a history of gestational diabetes mellitus
Authors: Liang Xin , Zheng Wei , Liu Cheng , Zhang Lirui , Zhang Li , Tian Zhihong , Li Guanghui 
Published: July 2021

AbstractBackgroundPregnant women with a history of gestational diabetes mellitus (GDM) are at high risk of GDM. It is unclear whether this population has pregnancy characteristics different from the general population. Whether these features affect the perinatal outcome has not yet been elucidated.MethodsA retrospective study was conducted, including baseline characteristics, laboratory data, gestational weight gain (GWG), and pregnancy outcomes of 441 pregnant women with prior GDM. Besides, 1637 women without a history of GDM treated in the same period were randomly selected as the control group. The above indicators of the two groups were compared. Multivariable logistic regression analysis was performed to investigate how GWG was associated with perinatal outcomes for previous GDM women.ResultsAmong women with GDM history, triglycerides (TG) and fasting plasma glucose (FPG) in the 1st trimester were higher than those without GDM history. GWG was lower in women with prior GDM relative to the control group at various pregnancy stages. However, women with GDM history had a higher risk of developing GDM (OR 3.25, 95% CI 2.26–4.68) and pregnancy-induced hypertension (OR 1.50, 95% CI 1.05–2.45). In women with previous GDM, excessive GWG before OGTT exhibited a positive correlation with pregnancy-induced hypertension (OR 1.47, 95% CI 1.05–3.32), while inadequate GWG was not a protective factor for GDM and pregnancy-induced hypertension.ConclusionWomen with prior GDM have glucose and lipid metabolism disorders in the 1st trimester. Limited reduction of GWG before oral glucose tolerance test (OGTT) was insufficient to offset the adverse effects of glucose and lipid metabolism disorders in women with previous GDM. Relevant interventions may be required at early stage or even before pregnancy.