bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Immunomodulatory Effect of Triptolide on Mesenchymal Stromal Cells
Authors: He Haiping , Takahashi Atsuko , Mukai Takeo , Hori Akiko , Narita Miwako , Tojo Arinobu , Yang Tonghua , Nagamura-Inoue Tokiko 
Published: August 2021

Mesenchymal stromal cells (MSCs) are known to have immunosuppressive ability and have been used in clinical treatment of acute graft-versus-host disease, one of severe complications of the hematopoietic stem cell transplantation. However, MSCs are activated to suppress the immune system only after encountering an inflammatory stimulation. Thus, it will be ideal if MSCs are primed to be activated and ready to suppress the immune reaction before being administered. Triptolide (TPL) is a diterpene triepoxide purified from a Chinese herb-Tripterygium wilfordii Hook.f. It has been shown to possess anti-inflammatory and immunosuppressive properties in vitro. In this study, we aimed to use TPL to prime umbilical cord-derived MSCs (TPL-primed UC-MSCs) to enter a stronger immunosuppressive status. UC-MSCs were primed with TPL, which was washed out thoroughly, and the TPL-primed UC-MSCs were resuspended in fresh medium. Although TPL inhibited the proliferation of UC-MSCs, 0.01 μM TPL for 24 h was tolerable. The surface markers of TPL-primed UC-MSCs were identical to those of non-primed UC-MSCs. TPL-primed UC-MSCs exhibited stronger anti-proliferative effect for activated CD4+ and CD8+ T cells in the allogeneic mixed lymphocyte reaction assay than the non-primed UC-MSCs. TPL-primed UC-MSCs promoted the expression of IDO-1 in the presence of IFN-γ, but TPL alone was not sufficient. Furthermore, TPL-primed UC-MSCs showed increased expression of PD-L1. Conclusively, upregulation of IDO-1 in the presence of IFN-γ and induction of PD-L1 enhances the immunosuppressive potency of TPL-primed UC-MSCs on the proliferation of activated T cells. Thus, TPL- primed MSCs may provide a novel immunosuppressive cell therapy.
Virtual Support in Dementia: A Possible Viable Strategy for Caregivers
Authors: Ferretti Ceres , Nitrini Ricardo , Brucki Sonia M. D. 
Published: August 2021

Background: In the last 10 months, due to the Covid-19 pandemic, several studies have shown that health education and virtual support strategies for caregivers of patients with dementia, in the management of home care, can be viable. Low and middle income countries, in particular, have sought to use these means to reduce the daily burden of caregivers, through virtual meetings of education and support.Objectives: To present the feasibility of a pilot study on the use of a support action contemplated by the Caad Project–indirect costs of dementia–from HC-FMUSP.Methods: Observational study in which 93 caregivers were invited to participate in virtual meetings on a frequency of three times/week, lasting 1 h each.Results: Of the 93 invited family members, and after 3 months, 42 answered eight questions about the effectiveness of the action. High percentages of positive responses regarding program satisfaction ranged from 86 to 100%.Conclusion: This study showed results of a very simple intervention that suggests that it is possible to offer caregivers of patients with dementia a program that can be used in primary care, in order to understand the difficulty of caregivers in their daily care of patients with dementia, with daily management guidelines on a case-by-case basis, in addition to promoting the implementation of an education strategy about the importance of knowing, and recognizing anatomophysiological changes in the aging process and its implications for the rupture of the imaginary line that involves senescence and senility. This allows the caregiver to feel able to protect his patient and himself by preventing the emergence of common diseases in this age group. Further studies are needed to explore this type of non-pharmacological support.
Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study
Authors: Wei Qing , Gao Yiding , Qi Changsong , Yuan Xing , Li Jingjing , Xu Qi , Luo Cong , Chen Lei , Zhuo Wei , Xu Zhiyuan , Ying Jieer 
Published: August 2021

BackgroundTo better define the clinicopathologic characteristics of signet ring cell (SRC) gastric cancer and build a prognostic model for it.MethodsSRC patient information from 2010 to 2015 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and log-rank test were used to estimate Overall survival (OS) and to determine associations with histologic subtypes. In COX proportional hazards regression model–based univariate and multivariate analyses, significant variables for construction of a nomogram were screened out. The nomogram was validated by means of the concordance index (CI), calibration plots, and receiver operating characteristics (ROCs) curves.ResultsA total of 11,363 gastric cancer patients were enrolled. On dividing the patients into SRC, well-to-moderately differentiated (WMD) adenocarcinoma, and poorly differentiated (PD) adenocarcinoma, differences among these subgroups emerged. SRC patients were more likely to occur in female and young patients than other histologic subtypes. Larger tumors, stage T4, and node stage N3 were more likely to be found in the SRC group. The survival for SRC patients was better than non-SRC patients in stage I. Univariate and multivariate analyses identified age, tumor site, larger tumor size, advanced T classification, advanced N classification, advanced TNM stage, and surgery of primary site as independent prognostic indicators. Then an OS nomogram was formulated.ConclusionsSRC had distinct clinicopathological characteristics. The nomogram provided an accurate tool to evaluate the prognosis of SRC.
The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial
Authors: Shu Hang , Dong Yaqin , Xu Zhonghua , Luo Weiwei , Xu Lei , Zhu Haochen , Cheng Linghui , Lv Yin 
Published: August 2021

ObjectiveTo investigate the short-term efficacy and safety of Endostar combined with concurrent chemoradiotherapy in the treatment of locally advanced cervical squamous cell carcinoma (LACSC).MethodsA total of 91 patients with LACSC admitted to the First Affiliated Hospital of Anhui Medical University from June 2019 to December 2020 were randomly assigned to either the experimental group (n = 48) or control group (n = 43). The control group received radiotherapy for cervical cancer and paclitaxel combined with platinum chemotherapy (CCRT), and the experimental group received Endostar continuous intravenous infusion of anti-angiogenic therapy plus CCRT. The short-term efficacy, common clinical indicators, tumor indicators, changes in serum vascular endothelial growth factor-A (VEGF-A), and the occurrence of adverse events (AEs) were explored after treatment.ResultsCompared with the control group, the complete response (CR) rate in the experimental group was significantly increased (83.33% vs 65.12%, P &lt; 0.05). Both routine indicators and tumor indicators in the two groups were significantly decreased compared to before treatment. Compared with the control group, patients in the experimental group had higher incidences of neutropenia, hypertension, and infection, but lower incidence of nausea. After treatment, the serological expression of VEGF-A was significantly decreased in both groups.ConclusionEndostar combined with CCRT in the treatment of LACSC can further improve the efficacy of CR rate and significantly reduce serum tumor indicators and VEGF-A levels, with mild and controllable AEs. Endostar combined with CCRT is expected to be a new treatment regimen for LACSC.
A Research on Frequently used Products from Sangam Literature
Authors: R Nallamuthu 
Published: August 2021

As to impoverished men this present world is not: The ‘graceless’ in you world have neither part nor lot. As the famous poet vazhuvar puts across this thought, we are surrounded and dependenton material possessions in this world. These asserts play a vital role in every stage and every event of our life. The relationship between oneself and the goods is too deep and enigmatic. In no way we withdraw ourselves from these domestic equipments. The materials connected to our everyday life can be tagged domestic products. These asserts help us in understanding and sangam period. On this note, the domestic products and its varieties are widely discussed. The research focuses on differentating these products namely: Domestic things, pottery, jewelleries made of gold, utensils made of stone, iron and bamboo made appliances.
New level comprehensive approach: living water engineering
Authors: Петрова Л.В. , Щербакова Ю.А. , Сизова И.М. 
Published: August 2021

Опыт и компетенции на рынке водоснабжения и водоотведения, накопленные компанией ЭКОС Групп за более чем 30 лет развития и профессионального роста, бесценны. Опираясь на многолетнюю историю реализованных проектов, собственный научно-технический, проектный и производственный потенциал, ЭКОС Групп предлагает сегодня инновационные решения актуальных и сложных задач, оперативно реагирует на быстро изменяющиеся условия на рынке очистки и повторного использования сточных вод, следует новым тенденциям профессиональной среды, учитывает кризисные процессы в экономике и конкретные нужды клиентов с заботой о планете, о людях, о будущем, о профессии. Комплексный подход в реализации проектов обеспечивает на каждом этапе выполнение своих обязательств, исключая риски неоправданных затрат и сокращая вред, наносимый окружающей среде.
The experience and competencies in the water supply and wastewater disposal market gained by ECOS Group over more than 30 years of development and professional growth, are invaluable. Based on the long history of implemented projects, scientific, technical, design and production and production experience, ECOS Group today offers innovative solutions to urgent and challenging tasks, quickly responds to rapidly changing conditions in the wastewater treatment and effluent reuse market, follows new trends in the professional environment. Ecos Group takes into account crisis processes in the economy and the specific needs of clients with care for the planet, people, the future, and the profession. A comprehensive approach to the implementation of projects ensures at every stage the fulfillment of the commitments eliminating the risks of unjustified costs and reducing damage to the environment.
Public-private partnership: case study of the wastewater treatment facilities in Novoshakhtinsk
Authors: Лановой А.С. , Чумаченко В.Н. , Иванов А.М. , Яковенко А.С. 
Published: August 2021

С момента перехода государства на новую экономическую модель развития социально значимые отрасли остались в тени «локомотивов» экономического развития – топливно-энергетического и минерально-сырьевого комплексов. Отрасли народного хозяйства, не имеющие коммерческого интереса, отмирали полностью или сжимались до размеров возможной минимальной окупаемости. Данные изменения затронули и отрасль жилищно-коммунального хозяйства, в частности водопроводно-канализационное хозяйство. Катастрофическое состояние отрасли в настоящее время требует особого внимания и особых решений со стороны всех участвующих и заинтересованных сторон: органов государственной и муниципальной власти, органов контроля и надзора, операторов систем водопроводно-канализационного хозяйства, коммерческих организаций, высшей школы, профильного научного сообщества и населения. Одна из базовых отраслей народного хозяйства не должна находиться в таком состоянии и, несмотря на отсутствие экономической стабильности, необходимо сделать ее восстановление приоритетной государственной задачей, направив на это максимальные материальные и интеллектуальные ресурсы страны. Приведен пример концессионного соглашения, которое иллюстрирует один из возможных путей продления ресурса городского канализационного хозяйства с предельным износом.
Since the transition of Russian Federation to a new economic model of development, socially significant industries have remained in the shadow of the «locomotives» of the economic development, i. e., the fuel and energy and mineral resource sectors. Branches of the national economy that had no commercial interest died out completely or shrank to the size of a possible minimum payback. These changes also affected the housing and utilities sector, in particular, the water supply and wastewater disposal systems. The catastrophic state of the industry currently requires special attention and special decisions on the part of all the stake holders: the state and municipal authorities, control and supervision bodies, operators of water and wastewater utilities, commercial organizations, higher education, the relevant scientific community and population. One of the basic sectors of the national economy should not be in such a state and, despite the lack of the economic stability, its restoration should be a priority state task directing the maximum material and intellectual resources of the country. An example of a concession agreement is given that can be a possible way to extend the resource of an urban wastewater disposal system with a wear limit.
HUBUNGAN ANTARA POLA ASUH DEMOKRATIS TERHADAP KONSEP DIRI REMAJA DI SMAN 11 KENDARI
Authors: Yana Egidya Chikita Defira , Aspin Aspin , Marhan Citra 
Published: August 2021

ABSTRAK : Pola asuh demokratis adalah suatu bentuk pola asuh yang memperhatikan dan menghargai kebebasan anak, adanya komunikasi yang dialogis antara anak dan orang tua, dan adanya sikap hangat yang ditunjukkan oleh orang tua kepada anaknya. Pola asuh orang tua memiliki peranan penting dalam upaya pembentukan konsep diri, pembentukan konsep diri remaja tidak terlepas dari penerapan pola asuh demokratis, yang menerapkan komunikasi dua arah, sehingga pembentukan konsep diri akan tercipta dari interaksi antara orang tua dengan anaknya. Penelitian ini bertujuan untuk mengetahui apakah ada hubungan antara pola asuh demokratis terhadap konsep diri remaja di SMAN 11 Kendari. Penelitian ini menggunakan metode kuantitatif dengan desain korelasional. Sampel dalam penelitian ini berjumlah 117 siswa. Teknik sampling yang digunakan adalah purposive sampling. Sumber data penelitian ini adalah siswa diukur dengan menggunakan skala pola asuh demokratis dan skala konsep diri. Analisis data menggunakan teknik korelasi Pearson Product Moment. Hasil dari penelitian ini menunjukan nilai koefisien korelasi (r) = 0,117 dengan nilai signifikansi (p) = 0.104. Nilai tersebut lebih besar dari 0.05, sehingga dapat diartikan bahwa tidak ada hubungan antara pola asuh demokratis terhadap konsep diri remaja di SMAN 11 Kendari. Kata Kunci: Pola Asuh Demokratis, Konsep Diri, Remaja
HUBUNGAN ANTARA KONFORMITAS TEMAN SEBAYA DENGAN MOTIVASI BERPRESTASI PADA REMAJA DI SMA NEGERI 1 KENDARI
Authors: Erhas Wardaningsih Widyasari , Darnawati Darnawati , Herik Eva 
Published: August 2021

Prestasi remaja di sekolah sangat ditentukan oleh motivasi berprestasi yang dimiliki oleh remaja. Tinggi rendahnya motivasi berprestasi dipengaruhi oleh lingkungan seperti teman sebaya. Remaja akan terpengaruh oleh aturan yang dibuat oleh kelompok teman sebaya dan akan mengubah sikap sesuai dengan keinginan orang lain yang disebut dengan konformitas. Bila remaja konformitas terhadap kelompok sebaya yang senang belajar, maka remaja akan terpengaruh untuk senang belajar sehingga memotivasi remaja untuk berprestasi begitupun sebaliknya. Penelitian ini bertujuan untuk mengetahui hubungan antara konformitas teman sebaya dengan motivasi berprestasi pada remaja di SMA Negeri 1 Kendari. Subjek penelitian berjumlah 40 orang dari kelas X IPS. Metode yang digunakan dalam penelitian ini adalah kuantitaif korelasional. Pengumpulan data menggunakan skala konformitas teman sebaya dan skala motivasi berprestasi. Sampel dalam penelitian ini dipilih berdasarkan teknik random sampling.. Hasil analisis korelasi Product Moment Pearson menunjukkan bahwa tidak terdapat hubungan yang signifikan antara konformitas teman sebaya dengan motivasi berprestasi pada remaja di SMA Negeri 1 Kendari dengan nilai signifikansi korelasi sebesar 0,670 dan korelasi pearson sebesar 0,070.Kata Kunci : Motivasi Berprestasi, Konformitas teman sebaya, Remaja
Status Ekonomi Orang Tua dengan Motivasi Belajar Siswa
Authors: Andreasari Nayla , Aspin Aspin , Kaimuddin Sitti Mikarna 
Published: August 2021

Motivasi dan belajar merupakan dua hal yang tidak dapat dipisahkan. Karena dengan motivasi, siswa akan semangat dalam proses belajar. Motivasi terbagi atas dua yaitu intrinsik dan ekstrinsik. Motivasi ekstrinsikmencakup keluarga. Status ekonomi orang tua dapat mempengaruhi motivas belajar; Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara status ekonomi orang tua dengan motivasi belajar siswa SD Negeri Matabaho dan SD Negeri 7 Langara Kecamatan Wawonii Barat; Jenis penelitian ini adalah kuantitatif dengan desain korelasional. Populasi dalam penelitian ini sebanyak 106 orang siswa yang terdiri dari kelas IV sampai dengan kelas VI. Teknik penarikan sampel dalam penelitian ini menggunakan Purposive Total Sampling sehingga ditemukan sampel sebanyak 89 orang siswa; Pengumpulan data dilakukan dengan menggunakan skala status ekonomi orang tua dan skala motivasi belajar; Teknik analisis data menggunakan formula korelasi Product Moment Pearson dengan menggunakan Statistical Product and Survice Solution (SPSS) 20.0; Berdasarkan hasil analisis data ditemukan nilai signifikansi sebesar 0,510 yang artinya tidak ada hubungan antara status ekonomi orang tua dengan motivasi belajar siswa SD Negeri Matabaho dan SD Negeri 7 Langara Kecamatan Wawonii Barat.
CHANGES IN BEHAVIOR OF LABORATORY RATS WHEN EXPOSED TO VARIOUS SENSORY ORGANS: VISION, TASTE, SMELL
Authors: Свиридова Алина Викторовна , Николенко Дарья Сергеевна , Абрамян Мария Владимировна , Алексеев Владимир Вячеславович 
Published: August 2021

В работе представлены выявленные изменения поведения крыс при проведении эксперимента «Открытое поле» с хроническим воздействием на различные анализаторы крыс. Предположен адаптивный характер полученных результатов, связанный со стрессовой ситуацией при воздействии на органы чувств крыс.
The paper presents the revealed changes in the behavior of rats during the "Open Field" experiment with chronic exposure to various rat analyzers. The adaptive nature of the results obtained is assumed to be associated with a stressful situation when exposed to the sensory organs of rats.
EXTREMISM: CLASSIFICATION PROBLEMS
Authors: Яхьяева Мархат Увайсовна 
Published: August 2021

Современный экстремизм разнообразен по формам своего выражения. Кроме того, он может быть классифицирован по различным теоретическим основаниям (сферам жизнедеятельности, объектам направленности экстремистской активности, возрастным характеристикам субъектов экстремистской активности и т.д.).
Contemporary extremism is diverse in its forms of expression. In addition, it can be classified according to various theoretical grounds (spheres of life, objects of orientation of extremist activity, age characteristics of the subjects of extremist activity, etc.).
ACTUAL ACCEPTANCE OF AN INHERITANCE
Authors: Умарова Амала Алиевна 
Published: August 2021

Рассмотрены общие положения ГК РФ о фактическом принятии наследства. Освещены проблемные вопросы процедуры установления факта принятия наследства, презумпции фактического принятия наследства, определения действий, свидетельствующих о намерении наследника принять наследство.
General provisions of the Civil Code of the Russian Federation concerning actual acceptance of an inheritance are considered. The author covers the topical issues of the procedure of fact finding of acceptance of an inheritance, presumption of the actual acceptance of an inheritance, identification of actions proving the intention of an heir to accept inheritance.
RECOMMENDATIONS FOR PREDICTING AND REDUCING THE LEVEL OF CONFLICT IN THE EDUCATIONAL ENVIRONMENT AT THE UNIVERSITY
Authors: Шахторина Екатерина Валентиновна , Голикова Юлия Андреевна 
Published: August 2021

В статье рассматривается актуальная на сегодняшний день проблема управления конфликтами в вузе. Авторами представлены рекомендации по снижению уровня конфликтности в вузе на основе эмпирического исследования и реализации конфликтологического мониторинга образовательной среды.
The article deals with the current problem of managing conflicts in a university. The authors present recommendations for reducing the level of conflict in the university based on empirical research and the implementation of conflictological monitoring of the educational environment.
Some issues of improving state planning in the sphere of cyber security in conditions of hybrid threats
Authors: GRIBOIEDOV S. 
Published: August 2021

The main principles of state strategic planning in the sphere of cybersecurity are considered. The directions of improvement of public administration in the field of cyber protection of a critical information infrastructure and state information resources are identified. The shortcomings of the Cyber Security Strategy of Ukraine in 2016 are analyzed and summarized. The draft of Cyber Security Strategy of Ukraine for 2021 – 2025 is considered and directions for its improvement are proposed. The prospects of strategic state planning in the sphere of cybersecurity in the context of the spread of hybrid threats are outlined.
The principles of institutional and functional support of cybersecurity in modern conditions
Authors: HURZHII S. 
Published: August 2021

Cyber threats in the context of the spread of modern challenges are outlined. The мeasures to strengthen the capacity of the national cybersecurity system are regulated. The priority principles of institutional and functional support for the development of the national cybersecurity system are detailed. The measures taken to institutionally strengthen security in cyberspace in some foreign countries are analyzed. The principles of forming the vertical of control and coordination of measures in the field of cybersecurity are highlighted. The powers of the National Coordination Center for Cyber Security as a working body of the National Security and Defense Council of Ukraine are outlined. The capacities of some actors in the national cybersecurity system have been clarified in order to avoid duplication. The directions of improvements of the priority principles of institutional and functional support of cybersecurity based on the threatening trends of today have been identified.