bluuebunny/crossref_metadata_2025_split huggingface dataset:
تأثير الدافعية الاستراتيجية في تحفيز السلوك الصوتي للموظفين دراسة استطلاعية لعينة من آراء مجالس كليات جامعة الكوفة
Authors: شاكر غفران رياض , العبادي هاشم فوزي 
Published: December 2024

الغرض من هذه الدراسة التحليلية هو التعمق في الديناميكيات المعقدة للدوافع الإستراتيجية وتأثيرها على السلوك الصوتي للموظفين ضمن النطاق الأكاديمي، وإدراكاً للدور المحوري لصوت الموظف في الابتكار والتطوير التنظيمي، تسعى الدراسة إلى توضيح الآليات التي من خلالها تؤثر الدافعية الاستراتيجية على مثل هذه السلوكيات وتحفزها، إذ تضمنت الدراسة التحليل النوعي للبيانات ذات الصلة بمجالس الكليات في جامعة الكوفة قيد الدراسة وشملت عينة الدراسة (200) استبيان على عينة من العاملين في مجالس الكليات الموقرة، وتمت معالجة البيانات من خلال الأساليب الإحصائية باستخدام البرنامج (SPSS) والكشف عن التفاعل الدقيق بين الدافعية الاستراتيجية والتعبير الناتج عن صوت الموظف.
أظهرت نتائج تحليل الإحصائي للبيانات التي تم جمعها من خلال أداة الاستبيان المعدة لهذا الغرض، بالإضافة الى الاستنتاجات النظرية منها: تسهم الدافعية الاستراتيجية في زيادة التعاون بين الموظفين والادارة وتقلل من الصراعات التنظيمية. فضلاً عن تقديم مجموعة من التوصيات من اجل تقديم رؤى قيمة في تعزيز مشاركة الموظفين وتعزيز ثقافة المشاركة الاستباقية داخل المؤسسات الأكاديمية.
Connected Healthcare System Technology Interventions to Improve Patient Safety by Reducing Medical Errors: A Systematic Review
Authors: Mondal Ramkrishna , Sameer Mohammed 
Published: December 2024

ABSTRACT
Medication or medical mistakes, the third highest cause of death in the United States, occur from prescription writing to administering the therapy, with serious clinical and cost repercussions. Digital health technologies, such as connected healthcare systems, have the potential to reduce pharmaceutical errors and increase patient safety. This systematic review was conducted to find literature evidence to improve patient safety and reduce medication errors with connected healthcare interventions. This systematic review was conducted using the PRISMA 2020 guidelines. PubMed, SCOPUS, EBSCO, and Google Scholar databases were searched from January 1, 2000 to June 30, 2024 using keywords: medication errors, patient safety, and connected healthcare. A qualitative narrative analysis was conducted for the review. The detailed search yielded 9524 papers in total. In the process of duplicate removal, 4856 duplicate articles were found. After the removal of duplicate articles, 4615 were found not suitable or relevant to the topic of this study and were removed. Finally, 53 articles were chosen for the review study after screening and duplication removal. Ten of the 53 articles were review articles (18.9%), and 43 (81.1%) were original. The research indicates that various connected healthcare system technologies are more effective in minimizing errors and enhancing care quality. Integrating computerized physician order entry and clinical decision support systems may further reduce medical errors. However, many areas require additional research, and the outcomes are mixed. A balanced strategy that combines innovation, practical safety, and outcome evaluation is preferable.
Nomogram based on a novel nutritional immune-inflammatory status score to predict postoperative outcomes in esophageal squamous cell carcinoma
Authors: Liu Qing-Wen , Liu Lin , Hu Jun-Xi , Hou Jia-Qi , He Wen-Bo , Shu Yu-Sheng , Wang Xiao-Lin 
Published: December 2024

BACKGROUND
The relationship between patient nutritional, immune, and inflammatory status is linked to tumor progression and prognosis. However, there are limited studies on the prognosis of esophageal squamous cell carcinoma (ESCC) after surgery based on the comprehensive indicators of these factors.
AIM
To develop and validate a novel nomogram based on a nutritional immune-inflammatory status (NIIS) score for predicting postoperative outcomes in ESCC.
METHODS
This retrospective study examined 829 patients with ESCC who underwent radical surgery between June 2016 and June 2020, with 568 patients in the training cohort and 261 patients in the validation cohort. We incorporated comprehensive indicators related to nutrition, immunity, and inflammation to develop the NIIS score, using LASSO regression. Subsequently, a nomogram combining the NIIS score and other clinicopathological parameters was developed and validated using calibration curves, time-dependent area under curves, and decision curve analysis.
RESULTS
We identified eight indicators that constitute the NIIS score. High-risk scores emerged as an independent risk factor for overall survival [training set HR 2.497 (1.802, 3.458), P < 0.001]. A NIIS nomogram for personalized prognostic prediction was developed by integrating the NIIS score with clinicopathological variables, yielding enhanced predictive value relative to individual indicators and the UICC/TNM staging system.
CONCLUSION
The NIIS score provides strong predictive value for postoperative outcomes in ESCC, thus offering a valuable tool for clinical decision-making.
Mild liver injury following withdrawal of long-term prednisone therapy: A case report
Authors: Zhu Jing-Wen , Yan Jun , Zhang Zhi-Han , Wang Tian-Qi 
Published: December 2024

BACKGROUND
Liver injury manifesting as hepatic enzyme abnormalities, has been occasionally identified to be a feature of primary or secondary Addison's disease, an uncommon endocrine disease characterized by adrenal insufficiency. There have been no more than 30 reported cases of liver injury explicitly attributed to Addison's disease. Liver injury resulting from adrenal insufficiency due to glucocorticoid withdrawal is exceptionally rarer.
CASE SUMMARY
A 42-year-old man presented with fatigue and mildly elevated transaminases. Laboratory investigations and imaging studies excluded common etiologies of liver injury. Based on the fact that the patient discontinued long-term therapy with prednisone approximately 2 weeks before he was found to have elevated transaminase levels and the observation that his cortisol was lower than the normal value, he was diagnosed as having hypertransaminasemia secondary to adrenal insufficiency caused by glucocorticoid withdrawal. The patient was infused intravenously with compound diisopropylamine dichloroacctate and compound glycyrrhizin, and his transaminase levels returned to normal after 1 week. Approximately 2 years later, the patient received hydroprednisone treatment for 2 days in an endoscopic sinus surgery. Eight days after he discontinued the hydroprednisone treatment, he developed symptoms reminiscent of glucocorticoid withdrawal syndrome. These symptoms resolved spontaneously after 1 week. Intriguingly, the patient did not develop hepatic dysfunction this time.
CONCLUSION
The present case, showing some unusual clinical features, highlights the importance of education of clinicians and patients to avoid improper discontinuation of glucocorticoid therapy and complete history taking for prompt recognition.
Bletilla striata polysaccharides alleviate metabolic dysfunction-associated steatotic liver disease through enhancing hepatocyte RelA/ HNF1α signaling
Authors: He Yi-Huai , Ou Li-Li , Jiang Jin-Lian , Chen Yun-Fen , Abudukeremu Aikedaimu , Xue Yuan , Mu Mao-Yuan , Zhong Wei-Wei , Xu De-Lin , Meng Xuan-Yu , Guan Ya-Qun 
Published: December 2024

BACKGROUND
Bletilla striata polysaccharides (BSP) have antioxidant, immune regulation, and anti-fibrotic activities. However, the therapeutic effect and mechanisms underlying the action of BSP in metabolic dysfunction-associated steatotic liver disease (MASLD) have not been fully understood.
AIM
To investigate the therapeutic effects and mechanisms of BSP on MASLD by centering on the hepatocyte nuclear factor kappa B p65 (RelA)/hepatocyte nuclear factor-1 alpha (HNF1α) signaling.
METHODS
A mouse model of MASLD was induced by feeding with a high-fat-diet (HFD) and a hepatocyte model of steatosis was induced by treatment with sodium oleate (SO) and sodium palmitate (SP). The therapeutic effects of BSP on MASLD were examined in vivo and in vitro . The mechanisms underlying the action of BSP were analyzed for their effect on lipid metabolism disorder, endoplasmic reticulum (ER) stress, and the RelA/HNF1α signaling.
RESULTS
HFD feeding reduced hepatocyte RelA and HNF1α expression, induced ER stress, lipid metabolism disorder, and necroptosis in mice, which were significantly mitigated by treatment with BSP. Furthermore, treatment with BSP or BSP-containing conditional rat serum significantly attenuated the sodium oleate/sodium palmitate (SO/SP)-induced hepatocyte steatosis by decreasing lipid accumulation, and lipid peroxidation, and enhancing the expression of RelA, and HNF1α. The therapeutic effects of BSP on MASLD were partially abrogated by RELA silencing in mice and RELA knockout in hepatocytes. RELA silencing or knockout significantly down-regulated HNF1α expression, and remodeled ER stress and oxidative stress responses during hepatic steatosis.
CONCLUSION
Treatment with BSP ameliorates MASLD, associated with enhancing the RelA/HNF1α signaling, remodeling ER stress and oxidative stress responses in hepatocytes.
Plan de Mejora en la Unidad Educativa “Cardenal Richard Cushing”
Authors: Mena Sinche Dayse , Armendáriz Zambrano Christian Ronald , Pérez Finol Ana Elisa Del Carmen 
Published: December 2024

Educational auditing and counselling are formal and interdependent processes that foster continuous improvement within educational processes. Auditing monitors and evaluates pedagogical and management processes based on national educational standards. At the same time, counselling is a technical action of a professional nature whose main function is to guide institutional management. In order to achieve educational excellence in the "Cardinal Richard Cushing" school, we proposed the design of an improvement plan to optimize the management of educational processes based on the evaluation of educational quality standards. In order to achieve this objective, a qualitative approach and action-research methodological design were used. The main results indicate that the institution has an organizational culture oriented towards quality, however, a small percentage of standards requires further analysis to suggest improvement actions that are aligned with this organizational culture.
PKM Pemberdayaan Masyarakat dalam Kepatuhan Peningkatan Pembayaran PBB di Desa Linggar Kecamatan Rancaekek Kabupaten Bandung, Jawa Barat Tahun 2023
Authors: Hamilah Hamilah , Reshciwati  , Nursiti  , Suci Triningsih Nur , Mulyawan Haris 
Published: December 2024

Tujuan dari pelaksanaan Pengabdian Masyarakat adalah untuk meningkatkan kepatuhan wajib pajak dalam peningkatan pembayaran PBB di Desa Linggar Kecamatan Rancaekek Kabupaten Bandung dimana tingkat kepatuhan dalam pembayaran PBB sangat rendah, Metode yang diterapkan adalah pendekatan kepada wajib Pajak PBB dengan metode pendekatan melalui Sosialisasi secara langsung , memberikan pemahaman pada warga Desa Linggar bahwa kewajiban wajib pajak sagat penting dalam pembayaran PBB, yang ke dua menbatu masayrakat dalam hal proses mel.akukan Update data atau mengajukan penerbitan SPPT baru PBB, mengingat lokasi wajib pajak cukup jauh ke Kantor pelayanan PBB.terkait pedistribusian SPPT PBB belum optimal karena masih banyak SPPT yang tercetak tidak sesuai dengan kepemilikan SPPT wajib pajak, ini terjadi karena Tanah dan bangunan tersebut sudah pindah tangan kepemilikan nya, dan untuk mengantisipasi tidak tersampaikan nya SPPT tersebut maka kami bekerja sama dengan mitra memberikan bantuan untuk warga tersebut. jumlah SPPT diwilayah Desa Linggar terdiri dari 4.117 SPPT dan pada Bulan september pada saat jatuh tempo pembayaran PBB hanya sejumlah 1130 SPPT PBB yang melakukan pembayaran dan sisanya sebesar 2.987 ini disebakan karena banyaknya SPPT PBB tidak sesuai dengan Luas tanah dan Bangunan yg dimiliki oleh pemilik terakhir.masih tertunggak atau belum melakukan pembayaran atau sebesar 58%. Hasil dari PKM terdapat kenaikan tingkat pembayaran Pajak dari sektor PBB sebesar 20% atau sebanyak 597 SPPT PBB. Perlu kami sampaikan bahwa harus ada Kebijakan dari Bapenda yaitu ada peninjauan kembali atas birokrasi dalam melakukan update PBB khusunya dalam hal persyarakat ( Misalnya tidak perlu dilegalisir AJB baik yang melalui PPATK atau yang melalui jalur Notaris ).
A Search for Asymmetric Kinematic Components in Circumstellar Envelopes Using OH Main Line Masers
Authors: Xie 谢 Jia-Yong 嘉泳 , Nakashima 中岛 Jun-ichi 淳一 , Zhang 张 Yong 泳 
Published: December 2024

Abstract
Circumstellar OH maser lines are useful for studying the dynamics of the circumstellar envelope (CSE) around evolved stars. This study aims to identify CSEs around cold stars, which exhibit deviations from the spherical expansion, by comparing the velocity ranges of the OH main lines (1665/1667 MHz) with those of the satellite line (1612 MHz), using a database of circumstellar OH maser sources. We performed this comparison for 377 circumstellar OH maser sources. In addition, using infrared two-color diagrams, we examined the evolutionary stages and infrared properties of objects showing velocity excess (velocity excess means the detection of the main lines outside the velocity range of the satellite line). A periodicity analysis of the Wide-field Infrared Survey Explorer (WISE) light curves was also carried out. As a result of the velocity range comparison, eight circumstellar OH maser sources were found to exhibit velocity excess. The infrared colors of these objects match those of postasymptotic giant branch (AGB) stars. Periodic variations were observed in the WISE light curves of five of these eight objects. The results suggest that examining the velocity excess of the main lines relative to the satellite line is scientifically significant because mainline masers probe the CSE dynamics over a broader range of evolutionary stages compared to the 22.235 GHz H2O maser line. Additionally, during the post-AGB phase, the emission regions of the mainline and 22.235 GHz H2O masers may overlap in a CSE, whereas they originate from different regions during the AGB phase.
Colposcopy Value in Young Child-bearing Women: Is New Recommendations Necessary?
Authors: Sabet Fahimeh , Aminizad Avishan , Behnamfar Fariba , Allameh Tajossadat , Shahrokh Seyedeh Ghazal , Koushan Rostami , Taravati Amirmohammad , Seresht Leila Mousavi 
Published: December 2024

Background:
Cervical cancer is a common malignancy in women and HPV infection is directly linked to it and can be considerably prevented through routine screenings. Despite the belief about the persistence of HPV infection in older than 30-year-old women, high-grade lesions might be detected in younger ages; therefore, the purpose of the current study is to determine the worth of HPV infection screening in younger than 30-year-old women.

Materials and Methods:
This cross-sectional study has been executed on 100 under 30-year-old women who have undergone genotyping. Fourteen HPV subtypes including HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were defined as high risk and the patients were categorized in HPV 16/18 or other high-risk groups. Pap smear and colposcopy were performed for both groups and interpreted as normal, low-risk and high-risk lesions and compared between the groups.

Results:
In terms of demographic, clinical, and sexual behavioral characteristics, the present study exhibited similarity (P value > 0.05). Pap smear (P value = 0.100) and colposcopy (P value = 0.711) grading did not differ between those with HPV 16/18 versus other high-risk HPV patients. Pap smear and colposcopic findings were weekly in agreement (κ < 0.5, P value < 0.001).

Conclusion:
Early cytological plus genotyping assessment in women at early child-bearing ages seems logical, as the cervical premalignant lesions have a slow progressing nature and can be easily treated in early stages.
Elucidating the Effects of Sleep Deprivation: Exploring fMRI Imaging Biomarkers to Analyze Brain Functions Related to Insomnia
Authors: Choghazardi Yazdan , Sabzevarian Fateme , Saber Korosh , Mansoory Meysam Siyah , Khodamoradi Mehdi , Sharini Hamid 
Published: December 2024

Background:
This study aimed to propose functional magnetic resonance imaging (fMRI) imaging biomarkers for the diagnosis of insomnia by examining the brain maps of young and old people during sleep deprivation (SD).

Materials and Methods:
A total of 50 healthy individuals were selected in two groups, including the young group: 17 people (20 to 30 years) and the elderly group: 23 people (65 to 75 years), who were involved in a 1-month period of SD, so that during the experiment they woke up 3 hours earlier than usual. Insomnia and sleepiness questionnaires were collected from these individuals (OpenfMRI website). Independent component analysis (ICA) processing was performed using the Generalized Intelligent Framework for Tutoring (GIFT) toolbox on old and young people’s data. Correlations between clinical variables and imaging were performed to extract insomnia biomarkers with a significance level of P = 0.05.

Results:
In the dynamic range variable, the difference in the effect of insomnia between the two groups was significant in areas such as the inferior occipital gyrus (IOG), superior temporal gyrus (STG), and posterior cingulate (PC). The fractional amplitude of low-frequency fluctuation (fALFF) variable in the anterior cingulate and precuneus areas, as well as the spatial map variable in areas such as the inferior semilunar lobule, anterior cingulate, subcallosal gyrus, and middle temporal gyrus (MTG) between the two groups, was significantly different (P = 0.05).

Conclusion:
Based on the results of this study, brain activity map in sleep-deprived people has a significant change in some brain areas and this effect is different in old and young adults.
Insulin Resistance in Type 2 Diabetes Mellitus: Pattern, Determinants, and Correlates in a Resource-Challenge Nigerian Setting
Authors: Ala Oluwabukola Ayodele , Uduagbamen Peter Kehinde , Yusuf Adebimpe Olukemi , Odeyemi Abiona Oluwadamilola , Olanrewaju Olayemi , Adedire Adejare , Adeyeye Abosede G. 
Published: December 2024

Abstract

Background:
Insulin resistance (IR) is an obesity and inflammation-associated condition driving the rising global prevalence of hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia. It is a modifiable risk factor for cardiometabolic disease due to its association with sedentary lifestyle and smoking.

Aims:
To assess IR and its associations in T2DM.

Materials and Methods:
This cross-sectional study analyzed 200 T2DM patients’ data and assessed its correlates and predictors using logistic regression.

Statistical analysis used:
Statistical Package for Social Sciences 26.

Results:
The mean age of the 200 participants was 58.96 ± 8.32 years, 19 (9.5%) were smokers and 54 (27%) had diabetes for more than 10 years. The waist–hip ratio was higher in women than men, P = 0.04. The hypertensives were older and had higher IR than those without hypertension, P = 0.04 and P < 0.001, respectively. The IR was positively correlated with the atherogenic index of plasma (AIP) and atherogenic coefficient (AQ), P = 0.04 and P < 0.001, respectively. Abdominal obesity, hypertension, hypertriglyceridemia, elevated triglyceride glycemic index (TGI), and low alpha lipoprotein (HDL) were more common in women than men. The elderly had higher AIP, TGI, and lower HDL, P < 0.001, P < 0.001, and P = 0.001, respectively. IR was associated with kidney dysfunction (P = 0.02). Smoking (OR 1.93, 95% CI 1.15–2.26), hypertension (OR 5.84, 95% CI 3.17–7.28), AIP (OR 8.23, 95% CI 2.58–8.14), and AQ (OR 11.63, 95% CI 4.07–13.47) independently predicted IR.

Conclusion:
IR contributes majorly to the rising global prevalence of hypertension, T2DM, and dyslipidemia. Its association with sedentary lifestyles and smoking makes it a modifiable risk factor for cardiometabolic and renal disease. All efforts are needed to curtail its rising trend.
Evaluation of Lipid Profile in Patients with Non-diabetic Chronic Kidney Disease
Authors: Das Dwijen , Hossale Basavachetan , Purayil Saran Kaatil 
Published: December 2024

Abstract

Background
Chronic kidney disease (CKD) is a global health concern associated with dyslipidemia, which contributes significantly to disease progression and cardiovascular risk. Understanding lipid profile alterations in non-diabetic CKD patients is crucial for improving management strategies.

Objectives
This study aimed to analyze lipid profiles in non-diabetic CKD patients and explore the association between lipid abnormalities and CKD severity.

Materials and Methods
A cross-sectional study involving 80 non-diabetic CKD patients was conducted at Tezpur Medical College and Hospital. Fasting lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured. GFR was estimated using the CKD Epidemiology Collaboration (CKD-EPI) equation. Correlations between lipid parameters and CKD stages were assessed statistically.

Results and Discussion
Dyslipidemia was observed in 65% of participants and was more prevalent in advanced CKD stages. A significant decline in HDL-C levels was observed with disease progression (P = 0.029). TG levels increased with advancing CKD but were not statistically significant (P = 0.343). No significant variation was noted in TC or LDL-C levels across stages. Significant correlations included a positive relationship between GFR and HDL-C (P < 0.05) and a negative relationship between TG and HDL-C (P < 0.01). These findings suggest that lipid abnormalities in CKD are influenced by insulin resistance, oxidative stress, and uremic toxins, contributing to cardiovascular risk.

Conclusion
This study underscores the high prevalence of dyslipidemia in non-diabetic CKD patients, with HDL-C serving as a potential marker of disease severity. Regular lipid monitoring and tailored interventions are essential to manage cardiovascular risk effectively.
Lower urinary tract symptoms and dysfunction as a result of functional constipation: a cross-sectional study
Authors: Mahfouz Aml , Wali Yasser , Metwally Rasha H , Fouad Ahmed H , Khalil Ahmed F 
Published: December 2024

Background
Lower urinary tract symptoms (LUTS) and dysfunction can be a significant complication of functional constipation (FC), especially in children. The relationship arises due to the close anatomical and functional connections between the bladder, bowel, and pelvic floor muscles.

Aim
The study aimed to investigate the presence of LUTS and the lower urinary tract dysfunction (LUTD). among children with FC.

Patients and methods
A cross-sectional descriptive study was carried out on children aged 4–10 years at the pediatric gastroenterology clinic of Alexandria University Children’s Hospital with an established diagnosis of FC according to Rome IV criteria. Age-adapted Agachan score was used to quantify the severity of FC. The Arabic version of the dysfunctional voiding symptom score (DVSS) was used to investigate the presence of LUTD.

Results
The study was conducted on 105 children (54 boys, 51 girls), 50.5% of the patients had positive DVSS scores; 62.3% were girls and 37.7% were boys with statistically significant positive DVSS in girls. Most patients had moderate to severe scores by using the age-adapted Agachan score. Multivariate logistic regression analysis was used to determine the independent predictors of bladder bowel dysfunction in patients with chronic FC. The independent predictors were dysuria, decreased voiding frequency, urgency, daytime incontinence, and female sex. History of bright red blood in the stools and the presence of anal fissures during the perianal examination were more common with bladder and bowel dysfunction patients than FC alone (P=0.011 and 0.027, respectively). The prognostic performance of age-adapted Agachan score to predict the positivity of DVSS score was found statistically significant.

Conclusion
Both LUTS and LUTD were correlated positively with FC, a crucial finding that necessitates the awareness of this finding.