bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lens-induced hypopyon uveitis as the presenting manifestation of posterior lens nucleus dislocation following pars-plana vitrectomy: case report
Authors: Imen Ksiaa , Meriam Ben Hadj Tahar , Ilhem Sellem , Sonia Attia , Nesrine Abroug , Moncef Khairallah 
Published: November 2021

AbstractA 57-year-old otherwise healthy male presented to our department seven days following uneventful pars-plana vitrectomy with gas tamponade for a superior bullous retinal detachment in the left eye. Ophthalmic examination revealed anterior segment inflammation with hypopyon and fibrinous exudate. Intra-ocular pressure was 28 mmHg. Posterior segment evaluation was difficult to assess due to the presence of anterior capsule opacification and gas bubble. A Toxic Anterior Segment Syndrome was suspected, and the patient was treated with topical and oral corticosteroid medication in combination with anti-glaucomatous therapy. On follow-up, anterior segment inflammation and ocular hypertension improved. On day ten post-operatively, ocular ultrasonography demonstrated lens material inferiorly with attached retina. The final diagnosis of posterior lens nucleus dislocation with lens-induced uveitis was retained. The patient underwent an uneventful second vitrectomy with aspiration of the dislocated lens nucleus and sulcus three piece-lens implantation. On last follow-up, visual acuity was 20/50 with no relapsing of ocular inflammation and the retina remained reattached.
Breast cancer-associated opsoclonus-myoclonus syndrome: a case report
Authors: Kostoglou Aikaterini , Vlastos Dimitrios , Bakalis Athanasios , Ghosh Debashis 
Published: November 2021

Abstract
Background
Paraneoplastic neurological syndromes constitute rare neurological complications of malignant disease, manifesting in <1% of patients with cancer. Opsoclonus-myoclonus syndrome (OMS) presents with chaotic ocular saccades (opsoclonus), spontaneous muscular jerking (myoclonus) that may be accompanied by ataxia, strabismus, aphasia, or mutism. Its paraneoplastic variant in the adult is most commonly associated with small-cell lung cancer, followed by breast cancer. Importantly, neurological symptoms usually precede the diagnosis of breast cancer and tend to recure after its treatment.

Case presentation
A 43-year-old premenopausal Caucasian woman with a medical history of hypertension was admitted following an episode of focal seizure. This progressed to generalised tonic-clonic seizures and she was subsequently loaded with phenytoin, valproate, and levetiracetam. Initial workup included whole body CT scan, viral and autoimmune serology. The CT scan revealed an enhancing right axillary lymph node, which in combination with Anti-Ri antibody positivity raised the spectre of paraneoplastic OMS. MRI of the head revealed subtle nonspecific white matter signal change within the centrum semiovale without any mass lesions, while MRI of the spine was unremarkable. An uncomplicated right mastectomy and axillary lymph node clearance was performed: histopathology revealed a 9-mm, grade 2, oestrogen receptor-positive, progesterone receptor-negative (ER8, PR0), Her2-negative invasive ductal carcinoma, and 4/6 positive lymph nodes (T1b N2 M0). Two months later, she was readmitted with vertigo, diplopia, facial weakness, and ataxia, setting the diagnosis anti-Ri syndrome recurrence. MDT recommended mammogram and ultrasound of the left breast, which were normal. Subsequently, four months after initial discharge, she suffered another neurological recurrence; due to concomitant abdominal pain, PET-CT was performed demonstrating a hypermetabolic right ovarian focus. Bilateral salpingo-oophorectomy was performed as per gynaecology MDT and final histology showed normal tubes and ovaries. She has remained on remission since then, with a negative annual mammogram follow-up.

Conclusions
In conclusion, we report a case of OMS associated with breast cancer anti-Ri onconeural antibody. Its manifestations preceded the diagnosis of malignancy and it persisted after cancer treatment, underlining the importance for high clinical suspicion in cases of classical paraneoplastic neurological syndromes as well as the need for long-term clinical follow-up.
Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis
Authors: Chen Yongqian , Miao Jintian , Lou Ge 
Published: November 2021

Abstract
Background
Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating the biological processes of PCOS. Our study was designed to explore the function of circ-FURIN in PCOS.

Methods
Circ-FURIN expression was detected using RT-qPCR. The protein expression of AVEN, BCL2, XIAP and AREL1 was measured using western blot. Dual-luciferase reporter and RNA pull-down assays were applied to clarify the interaction between miR-195-5p and circ-FURIN or BCL2. Functionally, cell proliferation was assessed by MTT and colony formation assays. Cell apoptosis was analyzed by flow cytometry.

Results
Circ-FURIN was upregulated in PCOS patients and granular cells (GCs). Knockdown of circ-FURIN inhibited cell proliferation and promoted apoptosis of KGN cells, along with the increased expression of caspase-3 and Bax and the decreased levels of p-PI3K. Gene ontology (GO) analysis indicated circ-FURIN is associated with apoptotic signaling pathway and cell death. Subsequently, BCL2 expression was elevated in patients with PCOS and positively regulated by circ-FURIN. Furthermore, circ-FURIN was served as a sponge of miR-195-5p to directly target to BCL2. The levels of miR-195-5p were reduced in PCOS and KGN cells. Knockdown of circ-FURIN decreased the expression of BCL2, which was abolished by miR-195-5p inhibitor. At last, rescue experiments revealed that overexpression of BCL2 reversed the effects of circ-FURIN knockdown on cell proliferation and apoptosis of KGN cells.

Conclusions
Loss of circ-FURIN alleviated the development of PCOS via miR-195-5p/BCL2 axis. Circ-FURIN may be the novel biomarker for PCOS.
Barriers and facilitators to adherence to national drug policies on antibiotic prescribing and dispensing in Bangladesh
Authors: Nizame Fosiul Alam , Shoaib Dewan Muhammad , Rousham Emily K. , Akter Salma , Islam Mohammad Aminul , Khan Afsana Alamgir , Rahman Mahbubur , Unicomb Leanne 
Published: November 2021

Abstract
Background
The National Drug Policy in Bangladesh prohibits the sale and distribution of antibiotics without prescription from a registered physician. Compliance with this policy is poor; prescribing antibiotics by unqualified practitioners is common and over-the-counter dispensing widespread. In Bangladesh, unqualified practitioners such as drug shop operators are a major source of healthcare for the poor and disadvantaged. This paper reports on policy awareness among drug shop operators and their customers and identifies current dispensing practices, barriers and facilitators to policy adherence.

Methods
We conducted a qualitative study in rural and urban Bangladesh from June 2019 to August 2020. This included co-design workshops (n = 4) and in-depth interviews (n = 24) with drug shop operators and customers/household members, key informant interviews (n = 12) with key personnel involved in aspects of the antibiotic supply chain including pharmaceutical company representatives, and model drug shop operators; and a group discussion with stakeholders representing key actors in informal market systems namely: representatives from the government, private sector, not-for-profit sector and membership organizations.

Results
Barriers to policy compliance among drug shop operators included limited knowledge of government drug policies, or the government-led Bangladesh Pharmacy Model Initiative (BPMI), a national guideline piloted to regulate drug sales. Drug shop operators had no clear knowledge of different antibiotic generations, how and for what diseases antibiotics work contributing to inappropriate antibiotic dispensing. Nonetheless, drug shop operators wanted the right to prescribe antibiotics based on having completed related training. Drug shop customers cited poor healthcare facilities and inadequate numbers of attending physician as a barrier to obtaining prescriptions and they described difficulties differentiating between qualified and unqualified providers.

Conclusion
Awareness of the National Drug Policy and the BPMI was limited among urban and rural drug shop operators. Poor antibiotic prescribing practice is additionally hampered by a shortage of qualified physicians; cultural and economic barriers to accessing qualified physicians, and poor implementation of regulations. Increasing qualified physician access and increasing training and certification of drug shop operators could improve the alignment of practices with national policy.
Valor da ciência, defesa do conhecimento e Perspectival Realism: Entrevista com Michela Massimi
Authors: Massimi Michela , Da Silva Vinicius Carvallho , Gurgel Ivã , Moraca Ronaldo 
Published: November 2021

Michela Massimi é professora de Filosofia da Ciência no Departamento de Filosofia da Universidade de Edimburgo, onde também é afiliada ao Higgs Centre for Theoretical Physics. Membro de importantes sociedades filosóficas e científicas, como a Royal Society of Edinburgh, a Royal Astronomical Society, e a Académie Internationale de Philosophie des Sciences (membro correspondente) é presidente eleita da PSA, Philosophy of Science Association, para o biênio 2023-2024. Massimi, com dupla nacionalidade, italiana e britânica, estudou na Sapienza Università di Roma, na London School of Economics, e lecionou História e Filosofia da Ciência na University College London antes de mudar-se para Edimburgo. Massimi trabalha com Filosofia da Ciência em uma abordagem marcada pelo recurso à pesquisa histórica. Seus interesses amplos abarcam a Filosofia da Cosmologia, o realismo científico, os estudos de ciências, as relações entre ciência e sociedade, entre outros tópicos. Tem se destacado por defender o que chama de Perspectival Realism, se afastando tanto do realismo tradicional, quanto do pragmatismo e do relativismo. Nessa entrevista dialogamos com Massimi sobre temas como o valor da ciência, a defesa da ciência em épocas de negacionismo e obscurantismo e as características de sua posição filosófica.
Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease
Authors: Carrillo Ileana , Rabelo Rayane Aparecida Nonato , Barbosa César , Rates Mariana , Fuentes-Retamal Sebastián , González-Herrera Fabiola , Guzmán-Rivera Daniela , Quintero Helena , Kemmerling Ulrike , Castillo Christian , Machado Fabiana S. , Díaz-Araya Guillermo , Maya Juan D. 
Published: November 2021

BackgroundChagas disease, caused by the protozoanTrypanosoma cruzi, is endemic in Latin America and is widely distributed worldwide because of migration. In 30% of cases, after years of infection and in the absence of treatment, the disease progresses from an acute asymptomatic phase to a chronic inflammatory cardiomyopathy, leading to heart failure and death. An inadequate balance in the inflammatory response is involved in the progression of chronic Chagas cardiomyopathy. Current therapeutic strategies cannot prevent or reverse the heart damage caused by the parasite. Aspirin-triggered resolvin D1 (AT-RvD1) is a pro-resolving mediator of inflammation that acts through N-formyl peptide receptor 2 (FPR2). AT-RvD1 participates in the modification of cytokine production, inhibition of leukocyte recruitment and efferocytosis, macrophage switching to a nonphlogistic phenotype, and the promotion of healing, thus restoring organ function. In the present study, AT-RvD1 is proposed as a potential therapeutic agent to regulate the pro-inflammatory state during the early chronic phase of Chagas disease.Methodology/Principal findingsC57BL/6 wild-type and FPR2 knock-out mice chronically infected withT.cruziwere treated for 20 days with 5 μg/kg/day AT-RvD1, 30 mg/kg/day benznidazole, or the combination of 5 μg/kg/day AT-RvD1 and 5 mg/kg/day benznidazole. At the end of treatment, changes in immune response, cardiac tissue damage, and parasite load were evaluated. The administration of AT-RvD1 in the early chronic phase ofT.cruziinfection regulated the inflammatory response both at the systemic level and in the cardiac tissue, and it reduced cellular infiltrates, cardiomyocyte hypertrophy, fibrosis, and the parasite load in the heart tissue.Conclusions/SignificanceAT-RvD1 was shown to be an attractive therapeutic due to its regulatory effect on the inflammatory response at the cardiac level and its ability to reduce the parasite load during early chronicT.cruziinfection, thereby preventing the chronic cardiac damage induced by the parasite.
Context, mechanisms and outcomes of dementia special care units: An initial programme theory based on realist methodology
Authors: Palm Rebecca , Fahsold Anne , Roes Martina , Holle Bernhard 
Published: November 2021

BackgroundDementia special care units represent a widely implemented care model in nursing homes. Their benefits must be thoroughly evaluated given the risk of exclusion and stigma. The aim of this study is to present an initial programme theory that follows the principles of realist methodology. The theory development was guided by the question of the mechanisms at play in the context of dementia special care units to produce or influence outcomes of interest in people with dementia.MethodsThe initial programme theory is based on qualitative interviews with dementia special care stakeholders in Germany and a realist review of complex interventions in dementia special care units. The interviews were analysed using content analysis techniques. For the realist review, a systematic literature search was conducted in four scientific databases; studies were appraised for quality and relevance. All data were analysed independently by two researchers. A realist informed logic model was developed, and context-mechanism-outcome (CMO) configurations were described.ResultsWe reviewed 16 empirical studies and interviewed 16 stakeholders. In the interviews, contextual factors at the system, organisation and individual levels that influence the provision of care in dementia special care units were discussed. The interviewees described the following four interventions typical of dementia special care units: adaptation to the environment, family and public involvement, provision of activities and behaviour management. With exception of family and public involvement, these interventions were the focus of the reviewed studies. The outcomes of interest of stakeholders include responsive behaviour and quality of life, which were also investigated in the empirical studies. By combining data from interviews and a realist review, we framed three CMO configurations relevant to environment, activity, and behaviour management.DiscussionAs important contextual factors of dementia special care units, we discuss the transparency of policies to regulate dementia care, segregation and admission policies, purposeful recruitment and education of staff and a good fit between residents and their environment.
Libertine Fashion: Sexual Freedom, Rebellion and Style, Adam Geczy and Vicki Karaminas (2020)
Authors: Gilligan Sarah 
Published: November 2021

Review of: Libertine Fashion: Sexual Freedom, Rebellion and Style, Adam Geczy and Vicki Karaminas (2020)
London: Bloomsbury Visual Arts (Dress, Body, Culture series), 256 pp.,
ISBN 978-1-35005-407-3, p/bk, h/bk, eBook, £24.99
The Dutch slavery and colonization DNA. A call to engage in self-examination
Authors: Steinmetz Carl H. D. 
Published: November 2021

This article answers the question whether there is a Dutch slavery and colonisation DNA. After all, the Netherlands has centuries of experience (approximately three and a half centuries) with colonisation (including occupation, wars and genocide, rearrangement of land and population, plundering and theft), trade in enslaved people (the Atlantic route: Europe, Africa, North and South America) and trade in the products of these enslaved people. The Netherlands has colonised large parts of the world. This was a large part of Asia, including the Indonesian archipelago, Malaysia, Ceylon, Taiwan and New Guinea, large parts of the continent Africa, including Madagascar, Mozambique, Cape of Good Hope, Luanda, Sao Tome, Fort Elmina etc., and North (New York) and South America (including Brazil, Dejima, Surinam and the Netherlands Antilles). It is a fact that human conditions and circumstances influence the human DNA that is passed on to posterity. This goes through the mechanism of methylation. This mechanism is used by cells in the human body to put genes in the "off" position. Human conditions and circumstances are abstractly formulated, poverty, hunger, disasters and wars. These are also horrors that accompanied slavery and colonisation. The Dutch, as slave traders, plantation owners, occupiers of lands, soldiers, merchants, captains and sailors, and administrators and their staff, have had centuries of experience with practising atrocities. Because those experiences are translated into the DNA of posterity, it is understandable that Dutch authorities misbehave towards immigrants and refugees. Those institutions are political leaders, governmental institutions, such as the tax authorities and youth welfare, and also companies that do their utmost to avoid taking on immigrants. This behaviour is called institutional colour and black racism.
Research on maintenance spare parts requirement prediction based on LSTM recurrent neural network
Authors: Song Weixing , Wu Jingjing , Kang Jianshe , Zhang Jun 
Published: November 2021

Abstract
The aim of this study was to improve the low accuracy of equipment spare parts requirement predicting, which affects the quality and efficiency of maintenance support, based on the summary and analysis of the existing spare parts requirement predicting research. This article introduces the current latest popular long short-term memory (LSTM) algorithm which has the best effect on time series data processing to equipment spare parts requirement predicting, according to the time series characteristics of spare parts consumption data. A method for predicting the requirement for maintenance spare parts based on the LSTM recurrent neural network is proposed, and the network structure is designed in detail, the realization of network training and network prediction is given. The advantages of particle swarm algorithm are introduced to optimize the network parameters, and actual data of three types of equipment spare parts consumption are used for experiments. The performance comparison of predictive models such as BP neural network, generalized regression neural network, wavelet neural network, and squeeze-and-excitation network prove that the new method is effective and provides an effective method for scientifically predicting the requirement for maintenance spare parts and improving the quality of equipment maintenance.
Dječja perspektiva prijelaza iz dječjeg vrtića u osnovnu školu
Authors: Visković Ivana , Mikulandra Karla 
Published: November 2021

Polazak u osnovnu školu, kao početak formalnog obrazovanja, značajan je događaj za većinu djece. Kvaliteta prijelaza iz predškolske ustanove u osnovnu školu povezana je s aktualnom i dugoročnom dobrobiti djeteta. Način na koji dijete doživljava prijelaz, razumije svrhovitost obrazovanja i osobnu ulogu u tome procesu utječe na početna postignuća, a posredno i na kasnije obrazovne ishode. U Konvenciji o pravima djeteta (1989) djeci se jamči pravo na izražavanje osobnog mišljenja i pravo da budu saslušana i uvažena, što je svrha i ovoga rada.
Rad daje prikaz empirijskog istraživanja perspektive djece u godini pred polazak u osnovnu školu (N=7). Kroz polustrukturirani intervju istraženo je dječje viđenje prijelaza, razumijevanje institucionalnog odgojno-obrazovnog procesa i svrhe obrazovanja te percepcija razlike dječjeg vrtića i osnovne škole. Svrha istraživanja jest razumijevanje i uvažavanje perspektive djece kao doprinos konstrukciji odgojno-obrazovnog kurikuluma dječjeg vrtića i osnovne škole. Većina djece u istraživanju veseli se polasku u osnovnu školu, spremno je preuzeti obveze i uloge učenika. Istodobno iskazuju strah od nepoznatog te nepovjerenje u osobna znanja. Djeca u istraživanju prepoznaju strukturalne razlike dječjeg vrtića i osnovne škole, načine i ishode učenja te uloge dionika procesa. Razlike pripisuju razini obveznosti („moranja“), samostalnosti i autonomije, vrsti aktivnosti i ulozi odraslih (roditelja, odgojitelja i učitelja). Navode jasne distinkcije između igre i učenja. Prethodno iskustvo i redoslijed rođenja u obitelji prepoznati su kao interventne varijable.
A syntactic complexity analysis of translational English across genres
Authors: Xu Jiajin , Li Jialei 
Published: November 2021

AbstractThis study compares the syntactic complexity between translational and non-translational English across four genres (i.e. fiction, news, general prose, and academic prose) and examines the connections between various forms and degrees of syntactic complexity measures and explicitation. Fourteen syntactic complexity indices were examined based on a one-million-word translational English corpus (COTE) and a one-million-word non-translational English corpus (i.e. FLOB), respectively. This study shows that syntactic explicitation in translations varies with the formality of discourse. The most significant complexity difference between translational vis-à-vis non-translational English is found in fiction, which is regarded as the major contributor to translational English syntactic complexity. No significant difference in syntactic complexity was observed between the two types of academic English texts. Translational English news and general prose stand between fiction and academic texts. Translational fiction and news are characterised by more phrasal complexity features such as coordinate and complex nominal phrases, and a key indicator of translational English general prose complexity is subordination. The findings of this study will help students of translation to make informed decisions on the arrangement of sentence structures when given texts of different genres.
Potrzeba mądrości wychowania w kontekście ludzkich dylematów
Authors: Drożdż Michał 
Published: November 2021

Potrzeba mądrości wychowania w kontekście ludzkich dylematów. Mądrość nauczyciela jest nieodłączna od umiejętności rozwiązywania ludzkich dylematów i trudności życiowych. Celem niniejszego artykułu jest pokazanie roli i zadań nauczyciela w kontekście wielu ludzkich dylematów. Na początku zostaną omówione dylematy związane z tajemnicą człowieka. Nauczyciel musi się także zmagać się z przejawami i skutkami ludzkiej niedojrzałości. Tematem wiodącym niniejszego artykułu jest teza o potrzebie mądrych nauczycieli, którzy potrafią na te wyzwania odpowiedzialnie odpowiadać dla dobra uczniów i rodziców. Punktem odniesienia w naszych analizach jest integralna antropologia personalistyczna. Zakładamy, iż mądrość jest dostępna, a prawda jest w stanie ukształtować nawet heroiczne charaktery nauczycielskie.