bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer
Authors: Zhang Zhuangzhuang , Cheng Lijun , Zhang Qiongsi , Kong Yifan , He Daheng , Li Kunyu , Rea Matthew , Wang Jianling , Wang Ruixin , Liu Jinghui , Li Zhiguo , Yuan Chongli , Liu Enze , Fondufe‐Mittendorf Yvonne N. , Li Lang , Han Tao , Wang Chi , Liu Xiaoqi 
Published: June 2021

AbstractBecause there is no effective treatment for late‐stage prostate cancer (PCa) at this moment, identifying novel targets for therapy of advanced PCa is urgently needed. A new network‐based systems biology approach, XDeath, is developed to detect crosstalk of signaling pathways associated with PCa progression. This unique integrated network merges gene causal regulation networks and protein‐protein interactions to identify novel co‐targets for PCa treatment. The results show that polo‐like kinase 1 (Plk1) and DNA methyltransferase 3A (DNMT3a)‐related signaling pathways are robustly enhanced during PCa progression and together they regulate autophagy as a common death mode. Mechanistically, it is shown that Plk1 phosphorylation of DNMT3a leads to its degradation in mitosis and that DNMT3a represses Plk1 transcription to inhibit autophagy in interphase, suggesting a negative feedback loop between these two proteins. Finally, a combination of the DNMT inhibitor 5‐Aza‐2’‐deoxycytidine (5‐Aza) with inhibition of Plk1 suppresses PCa synergistically.
Molecular mechanism of aggregation‐induced emission
Authors: Peng Qian , Shuai Zhigang 
Published: June 2021

AbstractDeep understanding of the inherent luminescence mechanism is essential for the development of aggregation‐induced emission (AIE) materials and applications. We first note that the intermolecular excitonic coupling is much weaker in strength than the intramolecular electron‐vibration coupling for a majority of newly termed AIEgens, which leads to the emission peak position insensitive to excitonic coupling, hence the conventional excitonic model for J‐aggregation cannot effectively explain their AIE phenomena. Then, using multiscale computational approach coupled with our self‐developed thermal vibration correlation function rate formalism and transition‐state theory, we quantitatively investigate the aggregation effect on both the radiative and the nonradiative decays of molecular excited states. For radiative decay processes, we propose that the lowest excited state could convert from a transition dipole‐forbidden “dark” state to a dipole‐allowed “bright” state upon aggregation. For the radiationless processes, we demonstrate the blockage of nonradiative decay via vibration relaxation (BNR‐VR) in harmonic region or the removal of nonradiative decay via isomerization (RNR‐ISO) or minimum energy crossing point (RNR‐MECP) beyond harmonic region in a variety of AIE aggregates. Our theoretical work not only justifies a plethora of experimental results but also makes reliable predictions on molecular design and mechanism that can be experimentally verified. Looking forward, we believe this review will benefit the deep understanding about the universality of AIE phenomenon and further extending the scope of AIE systems with novel applications.
Third Places, Social Capital, and Sense of Community as Mechanisms of Adaptive Responding for Young People Who Experience Social Marginalization
Authors: Littman Danielle Maude 
Published: June 2021

AbstractMany young people who experience social marginalization (such as young people of color, who identify as LGBTQ, and who have experienced housing instability, among others) have often faced significant trauma exposure and social oppression and may endure subsequent adverse impacts on their well‐being. Conversely, many such young people exhibit adaptive responding—the ability to maintain well‐being through and despite such contextual constraints. This theoretical paper illustrates a conceptual model for how third places—public settings which offer sociability and community connection—may foster adaptive responding through the mutually constitutive (i.e., mutually reinforcing and interrelated) mechanisms of psychological sense of community and social capital. As prior work on third places has not considered the social marginalization which many young people face, especially in public settings, this theoretical model also considers how social policing in third places potentially moderates the mutually constitutive relationships between participation in third places, social capital, and psychological sense of community. This paper ends with a proposed research agenda, which may empirically test this theoretical model and its assumptions through future model development. Lastly, key considerations for policy and practice are offered, with particular attention to how young people may be affirmed and welcomed in third places rather than socially policed.
Reversal Reactivity of β‐Alkylnitroalkenes as 1,3‐Binucleophiles: Application to Nitroarenes using Organocatalysis
Authors: Majee Debashis , Goud S Banuprakash , Guin Soumitra , Rathor Shikha S. , Patel Ashvani K. , Samanta Sampak 
Published: June 2021

AbstractAn efficient pyrrolidine : 4‐ClBzOH salt (catalyst IV) catalyzed [3+3] cyclization reaction of β‐alkyl‐substituted nitroalkenes as 1,3‐binucleophiles with various β‐aryl/alkyl/alkenyl‐substituted acroleins in an open‐atmosphere is reported. Eventually, this tunable organocatalytic reaction creates one C−C and C=C bonds selectively that turns out to have a wide substrate scope, which affords a series of substituted nitroarenes in good to high yields. In addition, several other positive features are associated with this organocatalytic approach such as evading toxic metal‐catalysts, no need for external oxidant and nitrating agent, 100% carbon‐economical, excellent tolerance of functionalities, water as a sole by‐product, circumventing of pre‐functionalized arenes etc. Moreover, a range of important hetero‐and carbocycles such as 2‐arylcarbazole, 2,6‐diphenylindole, 2′‐chloro‐1,1′ : 4′,1′′‐terphenyl and 1 : 1′ : 4′,1′′‐terphenyl were accessed from nitroarenes through our unique methods.
Introduction of protocols for mass production of Toxoplasma gondii tachyzoites of the genotype II PRU strain
Authors: Bahreini Mohammad Saleh , Nohtani Mohammad , Salemi Amir Masoud , Mirzaeipour Mehdi , Dastan Naghmeh , Bajelan Sara , Asgari Qasem 
Published: June 2021

AbstractBackgroundFew investigations of genotype II of Toxoplasma gondii, the most prevalent form of the Toxoplasma parasite in humans, have been carried out on due to the rapid conversion of tachyzoites to bradyzoites in its life cycle. The current study aimed to create animal and in vitro models for production of the tachyzoites of the Prugniaud (PRU) genotype II strain.MethodsTo develop an immunocompromised model and obtain tachyzoites of the PRU strain, BALB/c mice were orally treated with dexamethasone (10 mg/kg), cyclophosphamide (36 mg/kg), and cyclosporine (18 mg/kg) from 5 days prior to inoculation. Then, 10‐15 tissue cysts of PRU strain were inoculated intraperitoneally into the mice. The tachyzoites obtained from mice were then cultivated in a HeLa cell culture. The resulting yield of tachyzoites was cryopreserved in 92% fetal calf serum, 8% dimethyl sulfoxide. The infectivity of these tachyzoites was evaluated using in vivo and in vitro examinations.ResultsNumerous tachyzoites were observed in the peritoneal fluid of the immunosuppressed mice within 10‐15 days after inoculation, and many tachyzoites were harvested from the HeLa cell culture. Trypan Blue staining showed 80% viability of the tachyzoites recovered from cryopreservation and this was confirmed by HeLa cell culture. In addition, mice infected intraperitoneally with the recovered tachyzoites presented with cysts in the brain after 2 months.ConclusionWe have developed an animal model for mass production of T. gondii tachyzoites of the PRU strain. This method can provide fresh viable tachyzoites of Toxoplasma gondii for use as and when required in future investigations.
Experimental study on the influence of bionic channel structure on waste heat utilization equipment
Authors: Qi Cong , Tu Jianglin , Ding Zi , Wang Yuxing , Sun Liang , Wang Chengchao 
Published: June 2021

AbstractIn this paper, in order to improve the efficiency of waste heat utilization, based on the movement type and shape of the snake, snake bionic surfaces with different structures were designed, and CuO–H2O nanofluids were used instead of traditional working fluids, and they were coupled together and applied to waste heat utilization equipment. The main work is to experimentally study the effects of nanofluids mass fraction (w = 0.1 wt%, 0.3 wt%, 0.5 wt%), amplitude of bionic channel structure (A = 1 mm, A = 2 mm, A = 3 mm), angular frequency of bionic channel structure (ω = 20 rad/s, ω = 25 rad/s, ω = 30 rad/s), phase shift of bionic channel structure (α = 0°, 90°, 180°), and Reynolds number (Re = 1,300–1800) on the flow and heat transfer characteristics of working fluid. It was found that the heat transfer capacity of nanofluids increases with nanofluids mass fraction, angular frequency, amplitude and phase shift. Finally, the comprehensive performance of the whole experimental system was studied, and it was found that the greater the angular frequency, amplitude and phase shift, the better the comprehensive performance of the heat exchanger.
Fabrication of asymmetric zinc oxide/carbon nanotubes coated polysulfone photocatalytic nanocomposite membrane for fouling mitigation
Authors: Phin Hor Yan , Sin Jin Chung , Tan Soon Huat , Chew Thiam Leng , Ong Yit Thai 
Published: June 2021

AbstractMembrane filtration is a favorable option in water reclamation from contaminated water source, nevertheless, inevitable membrane fouling which greatly shortens membrane longevity and separation efficiency. The paper aimed to mitigate the membrane fouling through the formation of an asymmetric PSF‐ZnO/CNTs photocatalytic nanocomposite membrane. Instead of direct blending the photocatalyst into polymer matrix, the asymmetric nanocomposite membrane was prepared with prior formation of a self‐assembled ZnO/CNTs photocatalyst layer through wet‐processing technique followed with coating of PSF support layer via phase inversion method. The morphology of the nanocomposite membrane was characterized to confirm the formation of the asymmetric structure. The effect of ZnO/CNTs photocatalyst loading on the pore characteristic and antifouling properties of the PSF‐ZnO/CNTs nanocomposite membrane in dye remediation were assessed. The incorporation of ZnO/CNTs layer was found to endows the membrane with ability to photodegrade methylene blue. The PSF‐ZnO/CNTs membrane with 0.038 g ZnO/CNTs photocatalyst loading (M5) showed the greatest flux recovery ratio (98.46%) and the lowest irreversible fouling ratio (1.54%) while exhibited decent water permeability about 29.99 L/m2h without compromise the methylene blue rejection rate (91.04%).
High‐thermal conductivities of epoxy composites via p‐phenylenediamine interfacial modification and process intensification
Authors: Bao Di , Xu Fei , Cui Yexiang , Yuan Sicheng , Zhang Xiguang , Zhu Yanji , Gao Yueyang , Wang Huaiyuan 
Published: June 2021

AbstractHigh loadings of fillers are usually needed to achieve high‐thermal conductivity (TC) of polymer‐based composites, which inevitably sacrifices processability and meanwhile causes high‐cost. Therefore, it is of great significance to achieve high‐TC composites under low‐filler loading. Here, a novel p‐phenylenediamine (PPD) modified expanded graphite (EG‐PPD)/epoxy (EP) composite with high TC and low‐filler content was successfully prepared via pre‐dispersion and vacuum assisted mixing strategy. With the improved interfacial compatibility between EG and EP by PPD, the prepared EG‐PPD/EP composite exhibited excellent thermal management performance, resulting in the TC of which reached 4.00 W·m−1·K−1 with only 10 wt% (5.59 vol%) of EG‐PPD, which is approximately 19 times higher than that of pure EP. Meantime, the interface thermal resistance of EG‐PPD/EP composite between EG‐PPD and EP is reduced by 33% compared with EG/EP composite. This composite with excellent TC property is expected to be used in thermal management field.
Preparation and characterization of two‐way shape memory olefin block copolymer/silicone elastomeric blends
Authors: Lai Sun‐Mou , Chen Yen‐Ju , Yu Ben‐Yi 
Published: June 2021

AbstractVery few olefin block copolymer (OBC)‐based shape memory polymers (SMPs) studies were reported in the literature so far. This study investigated the preparation of OBC and silicone elastomeric blends (70/30 and 50/50) using a melt‐blending technique to form the first two‐way OBC‐based SMPs, to our best knowledge. Two phr of ((2,5‐bis(tert‐butylperoxy)‐2,5‐dimethylhexane (DHBP) was used to prepare flexible OBC/silicone D2 (D2 representing 2 phr of DHBP) networks. DHBP not only assisted the curing of OBC and silicone but also increased their compatibility in the blends. Despite the very low crystallinity of the OBC elastomer component, 10.4%, corresponding to only ~7% based on total resins in the OBC/silicone D2 70/30 blend, the rare two‐way shape memory behavior at such a low crystallinity was still envisaged. Regarding two‐way shape memory results at various loads, both entropy‐driven and crystallization‐driven contributions to the overall actuation magnitude (Ract) were at the highest level under 450 kPa, attributing to the highest orientation of molecular networks in the blends. With increasing the applied stress, the Ract of OBC/silicone (70/30) sample increased from 4.1% to 23.7% due to the increased strain‐induced crystallization effect confirmed by the XRD (X‐ray diffraction) evaluation, while the recovery magnitude (Rrec) was maintained at the high level, close to 90%, without the hindrance of high load on the recovery due to high elasticity of silicone rubber. Besides, the crystallization‐driven contribution to the overall actuation magnitude was higher for the blends containing the higher amount of crystalline OBC elastomer in the blends. On behalf of silicone with outstanding thermal stability, high elastic behavior, and high hydrophobicity, OBC/silicone SMP blends with versatile properties could meet different applications.
Predicting crowdfunding project success based on backers' language preferences
Authors: Du Qianzhou , Li Jing , Du Yanqing , Wang G. Alan , Fan Weiguo 
Published: June 2021

AbstractProject success is critical in the crowdfunding domain. Rather than the existing project‐centric prediction methods, we propose a novel backer‐centric prediction method. We identify each backer's preferences based on their pledge history and calculate the cosine similarity between backer's preferences and the project as each backer's persuasibility. Finally, we aggregate all the backers' persuasibility to predict project success. To validate our method, we crawled data on 183,886 projects launched during or before December 2014 on Kickstarter, a crowdfunding website. We selected 4,922 backers with a total of 442,793 pledges to identify backers' preferences. The results show that a backer is more likely to be persuaded by a project that is more similar to the backer's preferences. Our findings not only demonstrate the efficacy of backers' pledge history for predicting crowdfunding project success but also verify that a backer‐centric method can supplement the existing project‐centric approaches. Our model and findings enable crowdfunding platform agencies, fund‐seeking entrepreneurs, and investors to predict the success of a crowdfunding project.
Pitcher pot neourethral modification of ileal orthotopic neobladder achieves satisfactory long‐term functional and quality of life outcomes with low clean intermittent self‐catheterization rate
Authors: Jaipuria Jiten , Karimi Ahmad Mamoon , Singh Amitabh , Thapa Bikash Bikram , Gupta Shashikant , Sadasukhi Nripesh , Venkatasubramaniyan Manikandan , Pathak Preeti , Kasaraneni Priyatham , Khanna Ashish , Narayan Tushar Aditya , Sharma Girish , Rawal Sudhir 
Published: June 2021

AbstractObjectiveTo describe a decade of our experience with a neo‐urethral modification of ileal orthotopic neobladder (pitcher pot ONB). Multiple investigators have reported similar modifications. However, long‐term longitudinal functional and quality of life (QOL) outcomes are lacking.MethodsProspectively maintained hospital registry for 238 ONB patients comprising a mix of open and robotic surgery cohorts from 2007 to 2017, and minimum of 2 years of follow‐up was retrospectively queried. QOL was evaluated using Bladder Cancer Index (BCI). Longitudinal trends of QOL domain parameters were analysed. List of perioperative variables that have a biologically plausible association with continence, potency, and post‐operative BCI QOL sexual, urinary, and bowel domain scores was drawn. Variables included surgery type, Body Mass Index (BMI), T and N stage, neurovascular bundle (NVB) sparing, age, and related pre‐operative BCI QOL domain score. Prognostic associations were analysed using multivariable Cox proportional hazard models and multilevel mixed‐effects modeling.ResultsThe study comprised 80 and 158 patients who underwent open and robotic sandwich technique cohorts, respectively. Open surgery was associated with significantly higher “any” complication (40% vs 27%, P‐value .050) and “major” complication rate (15% vs 11%, P‐value .048). All patients developed a bladder capacity >400 cc with negligible post‐void residual urine, and all but one patient achieved spontaneous voiding by the end of study period (<1% clean intermittent self‐catheterization [CISC] rate). By 15 months, QOL for all three domains had recovered to reach a plateau. About 45% of patients achieved potency, and the median time to achieve day and night time continence was 9 and 12 months respectively. Lower age and NVBs spared during surgery were found to be significantly associated with the earlier achievement of potency, day and night time continence, as well as better urinary and sexual summary QOL scores.ConclusionsPitcher pot neobladder achieves satisfactory long‐term functional and QOL outcomes with negligible CISC rate. Results were superior with incremental nerves spared during surgery.
A practical guide to teaching withProteopedia
Authors: Castro Claudia , Johnson R. Jeremy , Kieffer Bruno , Means John A. , Taylor Ann , Telford Jason , Thompson Lynmarie K. , Sussman Joel L. , Prilusky Jaime , Theis Karsten 
Published: June 2021

AbstractProteopedia (proteopedia.org) is an open resource to explore the structure–function relationship of proteins and other biomolecules. This guide provides practical advice on how to incorporate Proteopedia into teaching the structure and function of proteins and other biomolecules. For 11 activities, we discuss desired outcomes, setting expectations, preparing students for the tasks, using resources within Proteopedia, and evaluating student work. We point out features of Proteopedia that make it especially suitable for teaching and give examples of how to avoid common pitfalls.
Does perceived cultural distance mediate the relationship between intergroup contact and support for refugee rights? A preliminary investigation
Authors: Firat Mustafa , Ataca Bilge 
Published: June 2021

AbstractDespite the importance of cultural difference perceptions in intergroup relations, prior work has paid insufficient attention to the intersection between intergroup contact, perceived cultural distance, and policy support. Using cross‐sectional data from a community sample of 210 Turkish citizens, this study examined whether perceived cultural distance would mediate the link between intergroup contact and support for Syrian refugee rights. The results showed that perceived cultural distance mediated the relationship between contact quality, but not contact quantity, and support for refugee rights. This mediated relationship was further moderated by political orientation, such that perceived cultural distance mediated the role of contact quality in support for refugee rights only among participants with a leftist (vs. rightist) orientation. Theoretical and practical implications of the findings were discussed, along with a reflection on future research directions. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
In Situ Hybridizing Cu3(BTC)2 and Titania to Attain a High‐Performance Copper Catalyst: Dual‐Functional Role of Metal‐Support Interaction on the Activity and Selectivity
Authors: Yang Xu , Zhang Zhaoxia , Liu Wu , Liang Tengda , Dang Dai , Tian Xinlong 
Published: June 2021

AbstractProduction of value‐added chemicals sourced from biomass platform molecules has tremendous significance for sustainable chemical engineering. Herein, we reported a successful fabrication of a highly dispersed copper nanoparticles catalyst, CuO#TiO2, via a facile route of in situ homogeneously hybridizing the metal organic framework Cu3(BTC)2 with titania, and subsequent calcination. Distinctly from the copper catalysts prepared by the conventional routes (impregnation or co‐precipitation), this novel CuO#TiO2 catalyst has a small particle size (∼5 nm), easy‐reducible copper species, and weakened Lewis's acidity. As a result, it shows superior high activity (∼20.8 molFUR/molCu ⋅ h) as well as high furfural alcohol yield (>99 %) at 140 °C and 2 MPa for furfural hydrogenation. Moreover, the CuO#TiO2 can be conveniently regenerated by calcination at 200 °C in the air, with no appreciable changes in its structure or activity, a test that we repeated 8 times. Through comprehensive structure characterizations, it has revealed a significant interaction between the CuO and TiO2 originated from the in situ hybridization, which enables a bi‐functional effect on the resulted CuO#TiO2 catalyst: one is to generate more copper active sites by promoting the copper dispersion and reducibility; the other is to hinder the side reactions by decrease the support Lewis acidity. This work demonstrates a practical strategy to rationally design a highly efficient catalytic system in furfural hydrogenation catalysis.