bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radio-laboratory findings in COVID-19 anosmia patients: a single-center experience
Authors: Algarf Tareq Muhammad , Youssef Mahmoud Atef , Elshazly Mostafa , Ismail Mohamed Said , Hasswa Mohamed Kamal , Mousa Mohamed Shaaban 
Published: July 2021

Abstract
Background
There is solid evidence that olfactory dysfunction (OD) can present in COVID-19 patients. Anosmia can be the only presentation or can be accompanied by other symptoms of COVID-19. Multiple cross-sectional studies have demonstrated that the incidence rate of olfactory dysfunction is high in COVID-19 patients with good prognosis. The aim of our study is to investigate the presence of OD with the radiologic and laboratory findings among COVID-19 positive patients.

Results
There was statistical significance in clinical severity between anosmia and non-anosmia group (P value 0.000) denoting that anosmia sign mostly occur in mild COVID. Also, there was significance in D dimer between two groups (P value 0.044) denoting that D dimer could be a sign of clinical severity and it is usually not elevated in anosmia. All anosmia group had normal CT chest denoting that it is a mild form of COVID-19.

Conclusions
Olfactory dysfunction (OD) is an imminent sign of COVID-19 patient, which can be presented as a sole symptom or with other symptoms. As anosmia could be the sole clinical presentation of COVID-19 patients without any other significant signs and so otolaryngologists should be aware of this presentation in COVID-19 diagnosis.
Role of multiparametric MRI in long-term surveillance following focal laser ablation of prostate cancer
Authors: Paxton Mark , Barbalat Eitan , Perlis Nathan , Menezes Ravi J , Gertner Mark , Dragas David , Haider Masoom A , Finelli Antonio , Trachtenberg John , Ghai Sangeet 
Published: July 2021

Objective:
Determine the multiparametric magnetic resonance imaging (mpMRI) appearance of the prostate following focal laser ablation (FLA) for PCa and to identify imaging characteristics associated with recurrent disease.

Methods:
Retrospective analysis of patients who underwent FLA for low-intermediate risk PCa between 2010 and 2014 was performed. Early (median 4 months) and late mpMRI (median 49 months) follow-up were qualitatively assessed for T 2-weighted, dynamic contrast enhanced (DCE) and diffusion weighted imaging (DWI) appearances and also compared to corresponding PSA values and biopsy results.

Results:
55 cancers were treated in 54 men (mean age 61.0 years). Early mpMRI was performed in 30 (54.5%) patients while late follow-up mpMRI in 42 (84%). Ill-defined scarring with and without atrophy at the treatment site were the most common appearances. In patients with paired MRI and biopsy, one of four patients with clinically significant PCa on biopsy (≥GG2 or≥6 mm GG1) showed hyperenhancement or restricted diffusion at early follow-up. At late follow-up, positive biopsies were seen in 5/8 (63%) cases with hyperenhancement and 5/6 (83%) cases with restricted diffusion at the treatment site. PSA change was not associated with biopsy results at either time point.

Conclusion:
mpMRI is able to document the morphological and temporal changes following focal therapy. It has limited ability to detect recurrent disease in early months following treatment. Late-term mpMRI is sensitive at identifying patients with recurrent disease. Small sample size is, however, a limitation of the study.

Advances in knowledge:
Implementing MRI in follow-up after FT may be useful in predicting residual or recurrent PCa and therefore provide reliable outcome data.
A remote self-directed psychological intervention for the public: The PAUSE programme protocol
Authors: Stafford Owen , Prendergast Cian , Berry Anna , Breslin Niall , Murphy Eddie , Gillan Diane , Godfrey Emmet , Barrett Katie , K. Taylor Laura , Shevlin Mark , McHugh Louise , Carr Alan , Burke Tom 
Published: July 2021

Background: This protocol outlines procedures for the development and evaluation of a remotely accessible intervention tool known as the ‘Psychology And yoU: Self-Enhancement programme’ (i.e., PAUSE programme). The PAUSE programme aims to support and promote psychological well-being using positive psychological concepts and principles. The programme has been developed in the context of the coronavirus disease 2019 pandemic, where effective and evidence-based remote interventions are needed. The PAUSE programme will provide users with valuable tools and skills that they may choose to implement in their daily lives, in order to foster and support positive mental well-being. The programme includes six modules: Well-being and Happiness; Healthy Body and Mind; Being Grateful and Savouring Life; Thought and Action; Strengthening Relationships; and Overcoming Challenges. Methods: Participants will be recruited using media outlets, social media, and professional networking websites in Ireland. Those who choose to participate in this study will be asked to complete a set of measures at baseline, immediate follow-up, and six weeks post-intervention. This will allow for changes in subjective well-being scores to be analysed and interpreted over time. This study adopts a Groups x Time design, with participants being randomly assigned to either an intervention or wait-list control group. Ethical approval is currently under review at the host institution. Dissemination: The dissemination strategy will follow the Evidence-based model for the Transfer and Exchange of Research Knowledge (EMTReK) and study findings will be prepared in line with various formats (e.g. study newsletters, conferences/meetings) in order to meet the needs of different audiences. Targeted and timely dissemination activities are anticipated, and the team intends to disseminate research in an ongoing manner, throughout the lifetime of the project. Registration: This RCT protocol is pre-results and has been registered with an international database resulting in an International Standard Randomised Controlled Trials Number (ISRCTN14772616)
Correction of thickness uniformity of multilayer fluoride coatings on steep spherical substrates using shadowing mask combinations in planetary rotation systems
Authors: Gong Shuang , Yang Baoxi , Huang Huijie 
Published: July 2021

In this study, the deposition angle parameter was introduced into the traditional deposition model to eliminate the coating thickness errors caused by large deposition angles and differences in the microstructures of coatings from the expected values. Based on the different thickness distributions of

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and

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coatings, a method that involves switching shadowing masks and a stepwise numerical optimization algorithm were proposed to control each coating thickness distribution accurately. When designing shadowing masks for a multilayer antireflective (AR) coating with a wide incident angle range, the correlation between the thickness distributions of the

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and

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layers was added to the merit function to ensure consistency in the two distributions. Two-layer deep-ultraviolet (DUV) AR fluoride coatings and a six-layer DUV low-polarization antireflection fluoride coating at 193 nm were fabricated on spherical substrate holders using thermal evaporation. In the experiment, when the ratio of the clear aperture to the radius of curvature was increased from

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to 1.63, the thickness uniformities of the

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layers of the two-layer DUV AR coatings on the fused silica substrates increased to a minimum of 98.49%. Owing to the transmission spectra and the incidence angle-resolved transmission, uniform optical performance and low-variation polarization transmittance were also achieved for the 193 nm AR coating deposited on the fused silica substrates.
T-grating on a nano-cavity array based refractive index sensor
Authors: Fatha Abed Yasir , Bhuiyan Md Asif Hossain , Choudhury Sajid Muhaimin 
Published: July 2021

We report a refractive index sensor comprising a unique T-grating on top of periodic nano-cavities. The sensor has two resonant modes sensitive to different regions of the structure with low inter-region interference, hence allowing simultaneous detection of two different analytes or more accurate detection of a single analyte. The sensor also provides a self-referencing feature for a broad range of refractive indices, from 1.3 to 1.5. Using the finite difference time domain method, sensitivities of 801.7 nm

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and 1386.8 nm

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were recorded for the two modes. The versatility of the structure makes the sensor a prominent candidate for biochemical and other sensing applications.
The experiences of trained breastfeeding support providers that influence how breastfeeding support is practised: A protocol for a qualitative evidence synthesis
Authors: Chesnel Mary Jo , Healy Maria , McNeill Jenny 
Published: July 2021

BackgroundMany women stop breastfeeding before they intend to as they cannot overcome breastfeeding difficulties. Breastfeeding support, as an evidence-based intervention by trained lay or professional breastfeeding support providers, can prevent early unintended cessation. Yet some women report dissatisfaction with support and reluctantly stop breastfeeding despite receiving this intervention. Understanding the experiences which shape how support is provided can inform effective implementation of breastfeeding support interventions. This review aims to synthesise experiences of trained breastfeeding support providers in high income settings and how these may influence their breastfeeding support practices.MethodsA qualitative systematic review of trained breastfeeding supporters’ experiences of supporting women to breastfeed, as part of a generic healthcare role or focused breastfeeding support role, will be conducted. A systematic search will be performed of the databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL +), MEDLINE ALL, Maternity and Infant Care, EMBASE, APA PsycINFO, Web of Science and Scopus. Title and abstract screening using eligibility criteria will be conducted usingCovidencesoftware. Eligible papers will be agreed by the review team following full text screening and reported using PRISMA guidelines. CASP and COREQ tools will assess study methodological quality and quality of reporting. Data will be extracted using a bespoke form and coded, using Excel software for data management. Analysis will involve the three stages of thematic synthesis: initial free coding, development of descriptive and subsequent analytical themes. Confidence in findings will be assessed using the CERQual framework.DiscussionThis review is the first to date to synthesise qualitative evidence on experiences which influence how trained lay and professional providers support women with breastfeeding. Findings will enable deeper understanding of the underpinning mechanisms of breastfeeding support provision and inform the development of tailored interventions to improve breastfeeding rates.Systematic review registrationPROSPERO registration number:CRD42020207380
Exploring predictors at toddler age of distinct profiles of attentional functioning in 6-year-old children born moderate-to-late preterm and full term
Authors: Bogičević Lilly , Verhoeven Marjolein , van Baar Anneloes L. 
Published: July 2021

Objective
Examining relationships of toddler abilities in attention, cognitive, motor, and language development, and behavioral problems, with distinct attention profiles at 6 years of age in children born moderate-to-late preterm and full term.

Method
Longitudinal study with a cohort of 88 moderate-to-late preterm and 83 full term born children. At 18 months attention abilities were assessed. At 24 months cognitive, motor, and language development was examined and behavioral problems were screened. At 6 years ten measures of attention were administered, which were used to classify children in one of four attentional functioning profiles (normal attention, overall poorer attention, poorer cognitive attention, and behavioral attention problems). Performance at 18 and 24 months was examined in relation to these four distinct attention profiles, as well as in relation to normal (first profile) versus subaverage attention (second, third, and fourth profiles) using multinomial logistic regressions.

Results
Orienting and alerting attention, and receptive language were related to distinct attention profiles. Specifically, children with an overall poorer attention profile at 6 years were differentiated by lower orienting attention and receptive language scores at toddler age, while those with a poorer cognitive attention profile showed lower early alerting attention at 18 months. Children with a behavioral attention problems profile at 6 years were differentiated by lower orienting attention but higher alerting attention scores at toddler age. Orienting attention and receptive language, but not alerting attention, at toddler age were related to normal versus subaverage attention, with lower scores predicting subaverage attention.

Conclusions
Children at risk of poorer attentional functioning at school-age, expressed in distinct attention profiles, already showed differentiated functioning in attention abilities and in language comprehension as toddlers. Distinguishing distinct attention profiles could be important for future research and clinical practice, as is early monitoring of attention and language abilities in children at risk.
Streamlining brain tumor surgery care during the COVID-19 pandemic: A case-control study
Authors: Mallari Regin Jay , Avery Michael B. , Corlin Alex , Eisenberg Amalia , Hammond Terese C. , Martin Neil A. , Barkhoudarian Garni , Kelly Daniel F. 
Published: July 2021

BackgroundThe COVID-19 pandemic forced a reconsideration of surgical patient management in the setting of scarce resources and risk of viral transmission. Herein we assess the impact of implementing a protocol of more rigorous patient education, recovery room assessment for non-ICU admission, earlier mobilization and post-discharge communication for patients undergoing brain tumor surgery.MethodsA case-control retrospective review was undertaken at a community hospital with a dedicated neurosurgery and otolaryngology team using minimally invasive surgical techniques, total intravenous anesthesia (TIVA) and early post-operative imaging protocols. All patients undergoing craniotomy or endoscopic endonasal removal of a brain, skull base or pituitary tumor were included during two non-overlapping periods: March 2019–January 2020 (pre-pandemic epoch) versus March 2020–January 2021 (pandemic epoch with streamlined care protocol implemented). Data collection included demographics, preoperative American Society of Anesthesiologists (ASA) status, tumor pathology, and tumor resection and remission rates. Primary outcomes were ICU utilization and hospital length of stay (LOS). Secondary outcomes were complications, readmissions and reoperations.FindingsOf 295 patients, 163 patients were treated pre-pandemic (58% women, mean age 53.2±16 years) and 132 were treated during the pandemic (52% women, mean age 52.3±17 years). From pre-pandemic to pandemic, ICU utilization decreased from 92(54%) to 43(29%) of operations (p<0.001) and hospital LOS≤1 day increased from 21(12.2%) to 60(41.4%), p<0.001, respectively. For craniotomy cohort, median LOS was 2 days for both epochs; median ICU LOS decreased from 1 to 0 days (p<0.001), ICU use decreased from 73(80%) to 29(33%),(p<0.001). For endonasal cohort, median LOS decreased from 2 to 1 days; median ICU LOS was 0 days for both epochs; (p<0.001). There were no differences pre-pandemic versus pandemic in ASA scores, resection/remission rates, readmissions or reoperations.ConclusionThis experience suggests the COVID-19 pandemic provided an opportunity for implementing a brain tumor care protocol to facilitate safely decreasing ICU utilization and accelerating discharge home without an increase in complications, readmission or reoperations. More rigorous patient education, recovery room assessment for non-ICU admission, earlier mobilization and post-discharge communication, layered upon a foundation of minimally invasive surgery, TIVA anesthesia and early post-operative imaging are possible contributors to these favorable trends.
Can we predict the severe course of COVID-19 - a systematic review and meta-analysis of indicators of clinical outcome?
Authors: Katzenschlager Stephan , Zimmer Alexandra J. , Gottschalk Claudius , Grafeneder Jürgen , Schmitz Stephani , Kraker Sara , Ganslmeier Marlene , Muth Amelie , Seitel Alexander , Maier-Hein Lena , Benedetti Andrea , Larmann Jan , Weigand Markus A. , McGrath Sean , Denkinger Claudia M. 
Published: July 2021

Background
COVID-19 has been reported in over 40million people globally with variable clinical outcomes. In this systematic review and meta-analysis, we assessed demographic, laboratory and clinical indicators as predictors for severe courses of COVID-19.

Methods
This systematic review was registered at PROSPERO under CRD42020177154. We systematically searched multiple databases (PubMed, Web of Science Core Collection, MedRvix and bioRvix) for publications from December 2019 to May 31st 2020. Random-effects meta-analyses were used to calculate pooled odds ratios and differences of medians between (1) patients admitted to ICU versus non-ICU patients and (2) patients who died versus those who survived. We adapted an existing Cochrane risk-of-bias assessment tool for outcome studies.

Results
Of 6,702 unique citations, we included 88 articles with 69,762 patients. There was concern for bias across all articles included. Age was strongly associated with mortality with a difference of medians (DoM) of 13.15 years (95% confidence interval (CI) 11.37 to 14.94) between those who died and those who survived. We found a clinically relevant difference between non-survivors and survivors for C-reactive protein (CRP; DoM 69.10 mg/L, CI 50.43 to 87.77), lactate dehydrogenase (LDH; DoM 189.49 U/L, CI 155.00 to 223.98), cardiac troponin I (cTnI; DoM 21.88 pg/mL, CI 9.78 to 33.99) and D-Dimer (DoM 1.29mg/L, CI 0.9 to 1.69). Furthermore, cerebrovascular disease was the co-morbidity most strongly associated with mortality (Odds Ratio 3.45, CI 2.42 to 4.91) and ICU admission (Odds Ratio 5.88, CI 2.35 to 14.73).

Discussion
This comprehensive meta-analysis found age, cerebrovascular disease, CRP, LDH and cTnI to be the most important risk-factors that predict severe COVID-19 outcomes and will inform clinical scores to support early decision-making.
Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary of a study protocol
Authors: Arévalos Victor , Ortega-Paz Luis , Fernandez-Rodríguez Diego , Alfonso Jiménez-Díaz Víctor , Rius Jordi Bañeras , Campo Gianluca , Rodríguez-Santamarta Miguel , de Prado Armando Pérez , Gómez-Menchero Antonio , Díaz Fernández José Francisco , Scardino Claudia , Gonzalo Nieves , Pernigotti Alberto , Alfonso Fernando , Jesús Amat-Santos Ignacio , Silvestro Antonio , Ielasi Alfonso , María de la Torre José , Bastidas Gabriela , Gómez-Lara Josep , Sabaté Manel , Brugaletta Salvatore ,   on behalf of the CV COVID-19 Registry Investigators
Published: July 2021

Background
Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes.

Study and design
This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials.gov number: NCT04359927). Consecutive patients older than 18 years, who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 in the participating institutions, will be included since March 2020, to August 2020. Patients will be classified into two groups, according to the results of the RT-PCR: COVID-19 positive or negative. The primary outcome will be cardiovascular mortality at 1 year. The secondary outcomes will be acute myocardial infarction, stroke, heart failure hospitalization, pulmonary embolism, and serious cardiac arrhythmias, at 1 year. Outcomes will be compared between the two groups. Events will be adjudicated by an independent clinical event committee.

Conclusion
The results of this registry will contribute to a better understanding of the long-term cardiovascular implications of the COVID19.
Magnetic resonance radiomics features and prognosticators in different molecular subtypes of pediatric Medulloblastoma
Authors: Chang Feng-Chi , Wong Tai-Tong , Wu Kuo-Sheng , Lu Chia-Feng , Weng Ting-Wei , Liang Muh-Lii , Wu Chih-Chun , Guo Wan Yuo , Chen Cheng-Yu , Hsieh Kevin Li-Chun 
Published: July 2021

Purpose
Medulloblastoma (MB) is a highly malignant pediatric brain tumor. In the latest classification, medulloblastoma is divided into four distinct groups: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. We analyzed the magnetic resonance imaging radiomics features to find the imaging surrogates of the 4 molecular subgroups of MB.

Material and methods
Frozen tissue, imaging data, and clinical data of 38 patients with medulloblastoma were included from Taipei Medical University Hospital and Taipei Veterans General Hospital. Molecular clustering was performed based on the gene expression level of 22 subgroup-specific signature genes. A total 253 magnetic resonance imaging radiomic features were generated from each subject for comparison between different molecular subgroups.

Results
Our cohort consisted of 7 (18.4%) patients with WNT medulloblastoma, 12 (31.6%) with SHH tumor, 8 (21.1%) with Group 3 tumor, and 11 (28.9%) with Group 4 tumor. 8 radiomics gray-level co-occurrence matrix texture (GLCM) features were significantly different between 4 molecular subgroups of MB. In addition, for tumors with higher values in a gray-level run length matrix feature—Short Run Low Gray-Level Emphasis, patients have shorter survival times than patients with low values of this feature (p = 0.04). The receiver operating characteristic analysis revealed optimal performance of the preliminary prediction model based on GLCM features for predicting WNT, Group 3, and Group 4 MB (area under the curve = 0.82, 0.72, and 0.78, respectively).

Conclusion
The preliminary result revealed that 8 contrast-enhanced T1-weighted imaging texture features were significantly different between 4 molecular subgroups of MB. Together with the prediction models, the radiomics features may provide suggestions for stratifying patients with MB into different risk groups.
Bahnhofsmission in Deutschland. Im Kontext der Epochen der Wohlfahrtspflege
Authors: Nikles Bruno W. 
Published: July 2021

Abstract
The ›Bahnhofsmissionen‹ developed in the context of the tradition of Christian non-profit welfare work in Germany. Through their supporting organisations, they belong to the associations of the Protestant Diakonie and the Catholic Caritas, which have held a dominant position in social work in German society for many decades. The ›Bahnhofsmissionen‹ are highly respected by the public but nontheless work under permanently precarious financial conditions. Without the large number of volunteers, the persistence of their work would not be safeguarded. This makes their 125-year history all the more astonishing, interrupted only by bans during the National Socialist era (between 1939-1945) and the German Democratic Republic (between 1956 and 1990).