bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in Printing Technologies of Nanomaterials for Implantable Wireless Systems in Health Monitoring and Diagnosis
Authors: Herbert Robert , Lim Hyo‐Ryoung , Park Sehyun , Kim Jong‐Hoon , Yeo Woon‐Hong 
Published: May 2021

AbstractThe development of wireless implantable sensors and integrated systems, enabled by advances in flexible and stretchable electronics technologies, is emerging to advance human health monitoring, diagnosis, and treatment. Progress in material and fabrication strategies allows for implantable electronics for unobtrusive monitoring via seamlessly interfacing with tissues and wirelessly communicating. Combining new nanomaterials and customizable printing processes offers unique possibilities for high‐performance implantable electronics. Here, this report summarizes the recent progress and advances in nanomaterials and printing technologies to develop wireless implantable sensors and electronics. Advances in materials and printing processes are reviewed with a focus on challenges in implantable applications. Demonstrations of wireless implantable electronics and advantages based on these technologies are discussed. Lastly, existing challenges and future directions of nanomaterials and printing are described.
Biowaste‐Derived Carbonized Bone for Solar Steam Generation and Seawater Desalination
Authors: Zafar Muhammad Shajih , Zahid Muhammad , Athanassiou Athanassia , Fragouli Despina 
Published: May 2021

AbstractInterfacial solar steam generation is an emerging strategy to improve the global freshwater supply. Herein, for the first time, a plausible alternative based on bone waste is presented for low‐cost solar steam generation and seawater desalination. This is accomplished via the exploration of the appropriate carbonization conditions for the successful bone transformation into a porous carbon‐based photothermal material. The carbonized bone (CB) not only is composed of inherent interlinked mesoporous microchannels for efficient water transportation but also displays broadband light absorption, photothermal conversion, and reduced vaporization enthalpy due to its special interactions with water. The as‐prepared CB shows an apparent evaporation rate of 1.82 kg m−2 h−1 under one‐sun illumination, attributed not only to its interaction with the sunlight but also to its performance in the dark field, and a solar‐to‐vapor conversion efficiency of 80%. Furthermore, CB desalinates water with an efficiency of 99.99%. Such performance combined with its wide availability, facile fabrication, and stability makes this biowaste‐based porous material a promising system for the production of freshwater. In this way, a valuable alternative for the valorization of bone‐based food‐waste is offered, paving the way to new routes for the management of such, continuously growing, food‐waste products.
Tris(pentafluorophenyl)borane‐Modified P3CT‐K as an Efficient Hole‐Transport Layer for Inverted Planar MAPbI3 Perovskite Solar Cells
Authors: You Gengshu , Liu Le , Wang Jin , Zhao Min , Zhao Chengjie , Cai Xu , Tang Jin , Lu Fushen , Jiu Tonggang 
Published: May 2021

AbstractPolythiophene‐acid‐based conjugated polyelectrolytes have shown great potential as hole‐transport materials for the fabrication of inverted planar perovskite devices with decent power conversion efficiencies (PCEs), benefiting from their tunable structure and functional properties. In contrast to the current progress mainly from side functional group modification, here a simple and effective strategy is reported to effectively regulate the aggregation of P3CT‐K through the modification of the thiophene units in the main chain. A small molecule tris(pentafluorophenyl)borane (TPB) is applied as the Lewis acid to interact with the thiophene unit of polythiophene chain and regulate the aggregation of conjugated polyelectrolytes. The control of aggregation of P3CT‐K not only elevates the hole mobility of P3CT‐K, but also suppresses charge recombination in P3CT‐K composite films. Consequently, the high efficiency of inverted MAPbI3 perovskite solar cells is achieved with a peak power conversion efficiency of 20.7% and simultaneously improved short‐circuit current density and fill factor. This work provides an effective method for the aggregation control of the polyelectrolyte hole materials to promote the performance of inverted planar perovskite solar cells.
The marmoset as an important primate model for longitudinal studies of neurocognitive aging
Authors: Rothwell Emily S. , Freire‐Cobo Carmen , Varghese Merina , Edwards Mélise , Janssen William G. M. , Hof Patrick R. , Lacreuse Agnès 
Published: May 2021

AbstractAge‐related cognitive decline has been extensively studied in humans, but the majority of research designs are cross‐sectional and compare across younger and older adults. Longitudinal studies are necessary to capture variability in cognitive aging trajectories but are difficult to carry out in humans and long‐lived nonhuman primates. Marmosets are an ideal primate model for neurocognitive aging as their naturally short lifespan facilitates longitudinal designs. In a longitudinal study of marmosets tested on reversal learning starting in middle‐age, we found that, on average, the group of marmosets declined in cognitive performance around 8 years of age. However, we found highly variable patterns of cognitive aging trajectories across individuals. Preliminary analyses of brain tissues from this cohort also show highly variable degrees of neuropathology. Future work will tie together behavioral trajectories with brain pathology and provide a window into the factors that predict age‐related cognitive decline.
Cyanine‐Dyad Molecular Probe for the Simultaneous Profiling of the Evolution of Multiple Radical Species During Bacterial Infections
Authors: Wang Zhimin , Cong Thang Do , Zhong Wenbin , Lau Jun Wei , Kwek Germain , Chan‐Park Mary B. , Xing Bengang 
Published: May 2021

AbstractReal‐time monitoring of the evolution of bacterial infection‐associated multiple radical species is critical to accurately profile the pathogenesis and host‐defense mechanisms. Here, we present a unique dual wavelength near‐infrared (NIR) cyanine‐dyad molecular probe (HCy5‐Cy7) for simultaneous monitoring of reactive oxygen and nitrogen species (RONS) variations both in vitro and in vivo. HCy5‐Cy7 specifically turns on its fluorescence at 660 nm via superoxide or hydroxyl radical (O2.−, .OH)‐mediated oxidation of reduced HCy5 moiety to Cy5, while peroxynitrite or hypochlorous species (ONOO−, ClO−)‐induced Cy7 structural degradation causes the emission turn‐off at 800 nm. Such multispectral but reverse signal responses allow multiplex manifestation of in situ oxidative and nitrosative stress events during the pathogenic and defensive processes in both bacteria‐infected macrophage cells and living mice. Most importantly, this study may also provide new perspectives for understanding the bacterial pathogenesis and advancing the precision medicine against infectious diseases.
Electrical Loss Management by Molecularly Manipulating Dopant‐free Poly(3‐hexylthiophene) towards 16.93 % CsPbI2Br Solar Cells
Authors: Li Ming‐Hua , Shao Jiang‐Yang , Jiang Yan , Qiu Fa‐Zheng , Wang Shuo , Zhang Jianqi , Han Guangchao , Tang Jilin , Wang Fuyi , Wei Zhixiang , Yi Yuanping , Zhong Yu‐Wu , Hu Jin‐Song 
Published: May 2021

AbstractInorganic cesium lead halide perovskites offer a pathway towards thermally stable photovoltaics. However, moisture‐induced phase degradation restricts the application of hole transport layers (HTLs) with hygroscopic dopants. Dopant‐free HTLs fail to realize efficient photovoltaics due to severe electrical loss. Herein, we developed an electrical loss management strategy by manipulating poly(3‐hexylthiophene) with a small molecule, i.e., SMe‐TATPyr. The developed P3HT/SMe‐TATPyr HTL shows a three‐time increase of carrier mobility owing to breaking the long‐range ordering of “edge‐on” P3HT and inducing the formation of “face‐on” clusters, over 50 % decrease of the perovskite surface defect density, and a reduced voltage loss at the perovskite/HTL interface because of favorable energy level alignment. The CsPbI2Br perovskite solar cell demonstrates a record‐high efficiency of 16.93 % for dopant‐free HTL, and superior moisture and thermal stability by maintaining 96 % efficiency at low‐humidity condition (10–25 % R. H.) for 1500 hours and over 95 % efficiency after annealing at 85 °C for 1000 hours.
Photo‐driven Oxygen Vacancies Extends Charge Carrier Lifetime for Efficient Solar Water Splitting
Authors: Sun Mao , Gao Rui‐Ting , He Jinlu , Liu Xianhu , Nakajima Tomohiko , Zhang Xueyuan , Wang Lei 
Published: May 2021

AbstractA photocharge/discharge strategy is proposed to initiate the WO3 photoelectrode and suppress the main charge recombination, which remarkably improves the photoelectrochemical (PEC) performance. The photocharged WO3 surrounded by a 8–10 nm overlayer and oxygen vacancies could be operated more than 25 cycles with 50 h durability without significant decay on PEC activity. A photocharged WO3/CuO photoanode exhibits an outstanding photocurrent of 3.2 mA cm−2 at 1.23 VRHE with a low onset potential of 0.6 VRHE, which is one of the best performances of p‐n heterojunction structure. Using nonadiabatic molecular dynamics combined with time‐domain DFT, we clarify the prolonged charge carrier lifetime of photocharged WO3, as well as how electronic systems of photocharged WO3/CuO semiconductors enable the effective photoinduced electrons transfer from WO3 into CuO. This work provides a feasible route to address excessive defects existed in photoelectrodes without causing extra recombination.
Synthesis of Azaylide‐Based Amphiphiles by the Staudinger Reaction
Authors: Yamashina Masahiro , Suzuki Hayate , Kishida Natsuki , Yoshizawa Michito , Toyota Shinji 
Published: May 2021

AbstractCatalyst‐ and reagent‐free reactions are powerful tools creating various functional molecules and materials. However, such chemical bonds are usually hydrolysable or require specific functional groups, which limits their use in aqueous media. Herein, we report the development of new amphiphiles through the Staudinger reaction. Simple mixing of chlorinated aryl azide with a hydrophilic moiety and various triarylphosphines (PAr3) gave rise to azaylide‐based amphiphiles NPAr3, rapidly and quantitatively. The obtained NPAr3 formed ca. 2 nm‐sized spherical aggregates (NPAr3)n in water. The hydrolysis of NPAr3 was significantly suppressed as compared with those of non‐chlorinated amphiphiles nNPAr3. Computational studies revealed that the stability is mainly governed by the decrease in LUMO around the phosphorus atom owing to the o‐substituted halogen groups. Furthermore, hydrophobic dyes such as Nile red and BODIPY were encapsulated by the spherical aggregates (NPAr3)n in water.
Dielectric properties of PMMA/KCTO(H) composites for electronics components
Authors: Vikulova Maria , Tsyganov Alexey , Bainyashev Alexey , Artyukhov Denis , Gorokhovsky Alexander , Muratov Dmitry , Gorshkov Nikolay 
Published: May 2021

AbstractPolymethyl methacrylate/hollandite‐like copper doped potassium titanate high‐k ceramics composites with different filler content (20–60 vol.%) are prepared by simple method of mixing of the polymer solution and ceramics dispersion followed evaporation of the solvent and hot pressing. The particle morphology and size are estimated by SEM. The composites obtained are studied by XRD, FTIR, and TGA methods. The influence of the additive and the concentration of hollandite‐like copper doped potassium titanate high‐k ceramics on dielectric properties (permittivity, conductivity, dielectric loss tangent) are investigated at frequency range from 10−1 to 106 Hz. It is shown that the increasing of ceramics concentration cause the increasing of main dielectric characteristics, namely permittivity up to 40 and dielectric loss up to 0.13 at 60 vol.% of filler and 0.1 Hz. Conductivity percolation threshold for PMMA/KCTO(H) composites was estimated (vc = 0.0773 vol. [20.9 wt. %]). Experimental data on permittivity are compared with different theoretical models (Lichtenecker's model and the Effective Medium Theory model).
Yolk@Shell Nanoreactors Carrying a Cluster of Metal Nanocrystals Stabilized Inside the Hollow Carbon Shell
Authors: Acharya Anubhab , Kumar Amit , Lee In Su 
Published: May 2021

Synthesis and stabilization of ultrasmall metal nanocrystals at high temperature have always been challenging due to their self‐aggregating behavior. Here, we introduce a strategy to synthesize a cluster of tiny metal nanocrystals (~3 nm) inside a hollow carbon shell as yolk@shell‐type architecture following a metal‐coordination‐based nanocrystal stabilization at high temperature (500 °C). The successful catalytic reduction of 2‐amino‐4‐nitrophenol demonstrates the efficiency of such nanoreactor in chemical transformation. Further adaptation of this strategy helps in synthesizing bimetallic (Au/Pt, Au/Pd, and Au/Ru) nanocrystals, which unfolds the possibilities to design advanced new‐generation catalysts.
Analysis of the neuroprotective effect of GLP‐1 receptor agonist peptide on cerebral ischemia‐reperfusion injury by Quantitative Proteomics Mass Spectrometry
Authors: Li Ying , Gong Min 
Published: May 2021

AbstractObjectiveThe pathological characteristics of cerebral ischemia‐reperfusion injury (CIRI) are complex, and the mechanism involved remains unknown. The treatment for CIRI has become an increasingly important challenge in the clinic, prompting us to explore the mechanism of CIRI. It was reported that GLP‐1 receptor agonist, Liraglutide, exhibited alleviating effects on CIRI. The previous findings suggested that the administration of Liraglutide in rodents results in the attenuation of the infarct volume following ischemia‐reperfusion injury by mediating the reactive oxygen species, apoptotic and necroptotic pathways.MethodsHere, a proteomic study was performed aiming to clarify the physiological protection role of GLP‐1 receptor agonist during the development of CIRI in MCAO mice. This proteomic investigations is contributed to reveal the mechanism associated with the treatment of GLP‐1 receptor agonist in MCAO mice.ResultsThe results indicated that the occurrence of ischemia‐reperfusion led to complex pathological processes, including inflammation, necroptosis and apoptosis. The treatment of Liraglutide significantly reduced the infract volume resulted from ischemia reperfusion injury. The proteomic data revealed that the administration of Liraglutide in MCAO mice induced the various effects on proteins expression level and phosphorylation.ConclusionsThe findings in this study was beneficial for identifying the novel therapeutic target for the treatment of ischemia reperfusion.
Synthesis of 3‐O‐Carboxyalkyl Morphine Derivatives and Characterization of Their Acid‐Base Properties
Authors: Köteles István , Mazák Károly , Tóth Gergő , Horváth Péter , Kiss Eszter , Tűz Boglárka , Hosztafi Sándor 
Published: May 2021

AbstractThe C‐3 phenolic hydroxy group containing morphine derivatives (morphine, oxymorphone, naloxone, naltrexone) are excellent candidates for the synthesis of 3‐O‐functionalized molecules. Achieving free carboxylic group containing derivatives gives the opportunity for further modification and conjugation that could be used for immunization and immunoassays. For this purpose ethyl bromo‐ and chloroacetate can be used as O‐alkylating agents. Hydrolyzing the products affords the appropriate free carboxylic group containing 3‐O‐carboxyalkyl derivatives. As these molecules contain an acidic and a basic functional group the protonation macro‐ and microconstants were determined too, using pH‐potentiometry and NMR‐pH titration, beside fully characterizing their structure using IR, CD, NMR and HR‐MS measurements.
New lesion after endovascular therapy of femoropopliteal lesions for intermittent claudication
Authors: Katsuki Tomonori , Yamaji Kyohei , Soga Yoshimitsu , Iida Osamu , Fujihara Masahiko , Kawasaki Daizo , Ando Kenji 
Published: May 2021

AbstractBackgroundAlthough the incidence of target lesion revascularization (TLR) was decreased in patients who underwent endovascular therapy (EVT) for femoropopliteal (FP) lesions, the clinical impact of newly developed lesions could not be disqualified in those patients.MethodsBetween January 2012 and December 2018, 911 patients with intermittent claudication (IC) who have not been previously treated for this condition underwent a successful EVT for de novo FP lesions in a multicenter registry (WATERMELON registry: neW lesion AfTer EndovasculaR therapy for interMittEnt cLaudicatiON).ResultsThe mean follow‐up duration was 3.5 ± 1.9 years. At 5 years, 53% patients underwent limb revascularization, (new lesion: 42% and TLR: 31%). We developed an ordinal risk score to predict the possibility of new lesion revascularization the following risk factors: body mass index (<23 kg/m2, 1 point), diabetes (2 points), hemodialysis (3 points), and atrial fibrillation (2 points). The patients were divided into three groups: low risk group (0–1 points: N = 283), intermediate risk group (2–3 points: N = 395), and high risk group (≥4 points: N = 233). The cumulative 5‐year incidence of new lesion revascularization was 28% in the low risk group, 40% in the intermediate group, and 68% in the high risk group (p < 0.001).Conclusionwithin 5 years after the first EVT, more than half of the patients underwent limb revascularization. Of these patients, 42% underwent new lesion revascularization. Patients with a body mass index <23 kg/m2, diabetes, hemodialysis, and atrial fibrillation had increased risk for new lesion revascularization.
Solution Processing of Topochemically Converted Layered WO3 for Multifunctional Applications
Authors: Sahoo Priyabrata , Gupta Bikesh , Chandra Sahoo Ramesh , Vankayala Kiran , Ramakrishna Matte H. S. S. 
Published: May 2021

AbstractSolution processing of nanomaterials is a promising technique for use in various applications owing to its simplicity and scalability. However, the studies on liquid‐phase exfoliation (LPE) of tungsten oxide (WO3) are limited, unlike others, by a lack of commercial availability of bulk WO3 with layered structures. Herein, a one‐step topochemical synthesis approach to obtain bulk layered WO3 from commercially available layered tungsten disulfide (WS2) by optimizing various parameters like reaction time and temperature is reported. Detailed microscopic and spectroscopic techniques confirmed the conversion process. Further, LPE was carried out on topochemically converted bulk layered WO3 in 22 different solvents; among the solvents studied, the propan‐2‐ol/water (1 : 1) co‐solvent system appeared to be the best. This indicates that the possible values of surface tension and Hansen solubility parameters for bulk WO3 could be close to that of the co‐solvent system. The obtained WO3 dispersions in a low‐boiling‐point solvent enable thin films of various thickness to be fabricated by using spray coating. The obtained thin films were used as active materials in supercapacitors without any conductive additives/binders and exhibited an areal capacitance of 31.7 mF cm−2 at 5 mV s−1. Photo‐electrochemical measurements revealed that these thin films can also be used as photoanodes for photo‐electrochemical water oxidation.
Titanium‐Oxo Clusters with Bi‐ and Tridentate Organic Ligands: Gradual Evolution of the Structures from Small to Big
Authors: Schubert Ulrich 
Published: May 2021

AbstractHomometallic titanium oxo clusters are one of the most important groups of metal oxo clusters, with more than 300 examples characterized by X‐ray structure analyses. Most of them are uncharged and are obtained by partial hydrolysis and condensation of titanium alkoxo derivatives. The cluster cores, ranging from 3 to >50 titanium atoms, are stabilized by organic ligands. Apart from residual OR groups, carboxylato and phosphonato ligands are most frequent. The article critically reviews and categorizes the known structures and works out basic construction principles by comparing the different cluster types.
Competing Effects of Chlorination on the Strength of Te⋅⋅⋅O Chalcogen Bonds Select the Structure of Mixed Supramolecular Macrocyclic Aggregates of Iso‐Tellurazole N‐Oxides
Authors: Ho Peter C. , Lomax Justin , Tomassetti Valerie , Britten James F. , Vargas‐Baca Ignacio 
Published: May 2021

AbstractChlorination of 3‐methyl‐5‐phenyl‐1,2‐tellurazole‐2‐oxide yielded the λ4Te dichloro derivative. Its crystal structure demonstrates that the heterocycle retains its ability to autoassociate by chalcogen bonding (ChB) forming macrocyclic tetramers. The corresponding Te⋅⋅⋅O ChB distances are 2.062 Å, the shortest observed to date in aggregates of this type. DFT−D3 calculations indicate that while the halogenated molecule is stronger as a ChB donor it also is a weaker ChB acceptor; the overall effect is that the ChBs in the chlorinated homotetramer are not significantly stronger. However, partial halogenation or scrambling selectively yield the 2 : 2 heterotetramer with alternating λ4Te and λ2Te centers, which calculations identified as the thermodynamically preferred arrangement.
Platinum Cyclooctadiene Complexes with Activity against Gram‐positive Bacteria
Authors: Frei Angelo , Ramu Soumya , Lowe Gabrielle J. , Dinh Hue , Semenec Lucie , Elliott Alysha G. , Zuegg Johannes , Deckers Anke , Jung Nicole , Bräse Stefan , Cain Amy K. , Blaskovich Mark A. T. 
Published: May 2021

AbstractAntimicrobial resistance is a looming health crisis, and it is becoming increasingly clear that organic chemistry alone is not sufficient to continue to provide the world with novel and effective antibiotics. Recently there has been an increased number of reports describing promising antimicrobial properties of metal‐containing compounds. Platinum complexes are well known in the field of inorganic medicinal chemistry for their tremendous success as anticancer agents. Here we report on the promising antibacterial properties of platinum cyclooctadiene (COD) complexes. Amongst the 15 compounds studied, the simplest compounds Pt(COD)X2 (X=Cl, I, Pt1 and Pt2) showed excellent activity against a panel of Gram‐positive bacteria including vancomycin and methicillin resistant Staphylococcus aureus. Additionally, the lead compounds show no toxicity against mammalian cells or haemolytic properties at the highest tested concentrations, indicating that the observed activity is specific against bacteria. Finally, these compounds showed no toxicity against Galleria mellonella at the highest measured concentrations. However, preliminary efficacy studies in the same animal model found no decrease in bacterial load upon treatment with Pt1 and Pt2. Serum exchange studies suggest that these compounds exhibit high serum binding which reduces their bioavailability in vivo, mandating alternative administration routes such as e. g. topical application.