bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Negotiation of a Feminist Sisterhood in the Pacific – Two Recent Cases of Intersectional Alliance Building
Authors: Alver Jane 
Published: June 2021

AbstractAn in‐depth analysis of two case studies – the Pacific Feminist Forum and the We Rise Coalition reveals the importance of alliance building in creating a form of ‘negotiated sisterhood’. Actors and activities in the gender equality civil society space play a role to push governments to make a diversity‐inclusive Pacific gender equality agenda. Working together as a regional alliance increases the impact of advocacy for including feminist voices in dialogues with regional institutions. A key lesson is that cross movement groups such as the women’s movement and gay and lesbian movements have different causes but can identify shared goals and engage in joint planning without excluding differences. This paper sheds new light on negotiating intersectional Pacific feminisms across difference, contributing ideas to mobilise more advocates for gender equality and inclusion in the Pacific.
Standardization of a SNP panel for parentage verification and identification in the domestic cat (Felis silvestris catus)
Authors: de Groot M. , Anderson H. , Bauer H. , Bauguil C. , Bellone R. R. , Brugidou R. , Buckley R. M. , Dovč P. , Forman O. , Grahn R. A. , Kock L. , Longeri M. , Mouysset‐Geniez S. , Qiu J. , Sofronidis G. , van der Goor L. H. P. , Lyons L. A. 
Published: June 2021

SummaryThe domestic cat (Felis silvestris catus) is a valued companion animal throughout the world. Over 60 different cat breeds are accepted for competition by the cat fancy registries in different countries. Genetic markers, including short tandem repeats and SNPs, are available to evaluate and manage levels of inbreeding and genetic diversity, population and breed structure relationships, and individual identification for forensic and registration purposes. The International Society of Animal Genetics (ISAG) hosts the Applied Genetics in Companion Animals Workshop, which supports the standardization of genetic marker panels and genotyping for the identification of cats via comparison testing. SNP panels have been in development for many species, including the domestic cat. An ISAG approved core panel of SNPs for use in cat identification and parentage analyses is presented. SNPs (n = 121) were evaluated by different university‐based and commercial laboratories using 20 DNA samples as part of the ISAG comparison testing procedures. Different SNP genotyping technologies were examined, including DNA arrays, genotyping‐by‐sequencing and mass spectroscopy, to select a robust and efficient panel of 101 SNPs as the ISAG core panel for cats. The SNPs are distributed across all chromosomes including two on the X chromosome and an XY pseudo‐autosomal sexing marker (zinc‐finger XY; ZFXY). A population study demonstrated that the markers have an average polymorphic information content of 0.354 and a power of exclusion greater than 0.9999. The SNP panel should keep testing affordable while also allowing for the development of additional panels to monitor health, phenotypic traits, hybrid cats and highly inbred cats.
Histology of some major immune system organs in Lake Van fish Alburnus tarichi (Güldenstädt, 1814) (Cyprinidae)
Authors: Kaptaner Burak , Aykut Handan , Doğan Emine , Bostancı Müşerref 
Published: June 2021

AbstractThe teleostean immune system is variable between and within taxa in terms of morphology. Accordingly, in the current study, the histology of some immune organs (thymus, kidney and spleen) of Lake Van fish (Alburnus tarichi) was investigated. For this purpose, the tissues from eight mature fish were fixed and embedded in paraffin wax, and then the sections were stained with haematoxylin and eosin, Mallory’s triple, periodic acid‐Schiff and Alcian blue (pH of 2.5) for histologic examinations. In the thymus, no clear discrimination of the cortex and medulla was observed. Lymphoid cells within a reticulo‐epithelial network were the predominant cell type in the thymus. The other components in the thymus were macrophages and myoid, mast‐like, plasma‐like, cystic cells, Hassall’s corpuscles, and single or multiple epithelial cystic structures. In the kidney, the head kidney, a major haematopoietic site, consisted of lymphoid and non‐lymphoid zones within a reticular network. Cells exhibiting mitotic figures were also detected in the haematopoietic tissue of the head kidney. Haematopoietic tissue was also found in the trunk kidney dispersed amongst the excretory components. The spleen was composed of red and white pulp. The red pulp comprised abundant erythrocytes, whilst the white pulp contained leucocytes with a reticular network. Ellipsoids were also determined in the white pulp. Melanomacrophage centres were found in all of the examined lymphoid tissues of the fish. These findings, which were reported, herein, for the first time will provide reference knowledge for future studies of this anadromous fish.
Gene‐based association analysis identified a novel gene associated with systemic lupus erythematosus
Authors: Ding Xian , Cai Minglong , Wang Sun , Yang Qingqing , Zheng Xiaodong , Zuo Xianbo , Liu Shengxiu 
Published: June 2021

SummaryObjectiveSystemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic predisposition. Genome‐wide association studies (GWAS) of SLE have identified more than 50 robust susceptibility loci. However, traditional individual SNP‐based GWAS have made it difficult to identify variants with small effects. Moreover, variants revealed by GWAS only explain a limited disease heritability, suggesting that many susceptibility genes remain uncovered.MethodsWe first curated the published SLE GWAS data from 1047 SLE patients and 1205 healthy controls of Chinese ancestry and performed a gene‐based association study. Then quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) was conducted to verify novel genes identified above.ResultsGene‐based association study identified 10 SLE‐associated genes, nine of which were reported by previous GWAS, the other one, ILRUN, is a newly identified gene and was further validated by qRT‐PCR. Gene expression analysis of Gene Expression Omnibus (GEO) datasets also showed that the expression of ILRUN in patients with SLE was lower than that in normal subjects.ConclusionIn this study, gene‐based association study and qRT‐PCR identified that ILRUN is a novel susceptibility gene of SLE. ILRUN may regulate inflammation and antiviral response through its effect on the transcription of type I interferons )I‐IFN, and participate in the pathogenesis of SLE.
Laparoscopic repair for primary epigastric hernia containing falciform ligament: A case report and review of literature
Authors: Takada Satoshi , Ueno Yuhei , Higashi Yuki , Nishijima Koji , Futagami Fumio 
Published: June 2021

AbstractFalciform ligament herniation is a rare type of epigastric hernia. We report a case of a primary epigastric hernia containing a falciform ligament repaired using nonabsorbable barbed suture under laparoscopic surgery. A 74‐year‐old woman presented with discomfort in the upper abdomen. Physical examination revealed a 3‐cm non‐tender mass, and abdominal computed tomography revealed epigastric hernia with an incarcerated falciform ligament. By observation with a laparoscope, the fascial defect was single and 1.0 cm in diameter, thus sutured repair was selected. At 4 months follow‐up, she had no complications or recurrence. The laparoscopic approach is useful for diagnosis and deciding a repair method of an epigastric hernia. The barbed suture closure system is convenient and effective for intracorporeal hernial defect closing. Both primary and incisional falciform ligament herniation have been reported in the past, and we reviewed six cases, including our case.
Multivariate Bayesian clustering using covariate‐informed components with application to boreal vegetation sensitivity
Authors: Scharf Henry R. , Raiho Ann M. , Pugh Sierra , Roland Carl A. , Swanson David K. , Stehn Sarah E. , Hooten Mevin B. 
Published: June 2021

AbstractClimate change is impacting both the distribution and abundance of vegetation, especially in far northern latitudes. The effects of climate change are different for every plant assemblage and vary heterogeneously in both space and time. Small changes in climate could result in large vegetation responses in sensitive assemblages but weak responses in robust assemblages. But, patterns and mechanisms of sensitivity and robustness are not yet well understood, largely due to a lack of long‐term measurements of climate and vegetation. Fortunately, observations are sometimes available across a broad spatial extent. We develop a novel statistical model for a multivariate response based on unknown cluster‐specific effects and covariances, where cluster labels correspond to sensitivity and robustness. Our approach utilizes a prototype model for cluster membership that offers flexibility while enforcing smoothness in cluster probabilities across sites with similar characteristics. We demonstrate our approach with an application to vegetation abundance in Alaska, USA, in which we leverage the broad spatial extent of the study area as a proxy for unrecorded historical observations. In the context of the application, our approach yields interpretable site‐level cluster labels associated with assemblage‐level sensitivity and robustness without requiring strong a priori assumptions about the drivers of climate sensitivity.
A Bayesian nonparametric approach for inferring drug combination effects on mental health in people with HIV
Authors: Jin Wei , Ni Yang , Rubin Leah H. , Spence Amanda B. , Xu Yanxun 
Published: June 2021

AbstractAlthough combination antiretroviral therapy (ART) with three or more drugs is highly effective in suppressing viral load for people with HIV (human immunodeficiency virus), many ART agents may exacerbate mental health‐related adverse effects including depression. Therefore, understanding the effects of combination ART on mental health can help clinicians personalize medicine with less adverse effects to avoid undesirable health outcomes. The emergence of electronic health records offers researchers' unprecedented access to HIV data including individuals' mental health records, drug prescriptions, and clinical information over time. However, modeling such data is challenging due to high dimensionality of the drug combination space, the individual heterogeneity, and sparseness of the observed drug combinations. To address these challenges, we develop a Bayesian nonparametric approach to learn drug combination effect on mental health in people with HIV adjusting for sociodemographic, behavioral, and clinical factors. The proposed method is built upon the subset‐tree kernel that represents drug combinations in a way that synthesizes known regimen structure into a single mathematical representation. It also utilizes a distance‐dependent Chinese restaurant process to cluster heterogeneous populations while considering individuals' treatment histories. We evaluate the proposed approach through simulation studies, and apply the method to a dataset from the Women's Interagency HIV Study, showing the clinical utility of our model in guiding clinicians to prescribe informed and effective personalized treatment based on individuals' treatment histories and clinical characteristics.
The nonsmokers’ and smokers’ pathways in lung adenocarcinoma: Histological progression and molecular bases
Authors: Okudela Koji , Matsumura Mai , Arai Hiromasa , Woo Tetsukan 
Published: June 2021

AbstractThere could be two carcinogenetic pathways for lung adenocarcinoma (LADC): the nonsmokers’ pathway and the smokers’ pathway. This review article describes the two pathways with special reference to potential relationships between histological subtypes, malignant grades, and driver mutations. The lung is composed of two different tissue units, the terminal respiratory unit (TRU) and the central airway compartment (CAC). In the nonsmokers’ pathway, LADCs develop from the TRU, and their histological appearances change from lepidic to micropapillary during the progression process. In the smokers’ pathway, LADCs develop from either the TRU or the CAC, and their histological appearances vary among cases in the middle of the progression process, but they are likely converged to acinar/solid at the end. On a molecular genetic level, the nonsmokers’ pathway is mostly driven by EGFR mutations, whereas in the smokers’ pathway, approximately one‐quarter of LADCs have KRAS mutations, but the other three‐quarters have no known driver mutations. p53 mutations are an important factor triggering the progression of both pathways, with unique molecular alterations associated with each, such as MUC21 expression and chromosome 12p13‐21 amplification in the nonsmokers’ pathway, and HNF4α expression and TTF1 mutations in the smokers’ pathway. However, investigation into the relationship between histological progression and genetic alterations is in its infancy. Tight cooperation between traditional histopathological examinations and recent molecular genetics can provide valuable insight to better understand the nature of LADCs.
Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model
Authors: Ohkawa Yuki , Zhang Pu , Momota Hiroyuki , Kato Akira , Hashimoto Noboru , Ohmi Yuhsuke , Bhuiyan Robiul H. , Farhana Yesmin , Natsume Atsushi , Wakabayashi Toshihiko , Furukawa Keiko , Furukawa Koichi 
Published: June 2021

AbstractHigh expression of gangliosides GD3 and GD2 is observed in human gliomas. The functions of GD3 and GD2 in malignant properties have been reported in glioma cells in vitro, but those functions have not yet been investigated in vivo. In this study, we showed that deficiency of GD3 synthase (GD3S, St8sia1) attenuated glioma progression and clinical and pathological features in a platelet‐derived growth factor B‐driven murine glioma model. Lack of GD3S resulted in the prolonged lifespan of glioma‐bearing mice and low‐grade pathology in generated gliomas. Correspondingly, they showed reduced phosphorylation levels of Akt, Erks, and Src family kinases in glioma tissues. A DNA microarray study revealed marked alteration in the expression of various genes, particularly in MMP family genes, in GD3S‐deficient gliomas. Re‐expression of GD3S restored expression of MMP9 in primary‐cultured glioma cells. We also identified a transcription factor, Ap2α, expressed in parallel with GD3S expression, and showed that Ap2α was critical for the induction of MMP9 by transfection of its cDNA and luciferase reporter genes, and a ChIP assay. These findings suggest that GD3S enhances the progression of gliomas by enhancement of the Ap2α‐MMP9 axis. This is the first report to describe the tumor‐enhancing functions of GD3S in vivo.
Accuracy of computer‐assisted, template‐guided implant placement compared with conventional implant placement by hand—An in vitro study
Authors: Schneider David , Sax Caroline , Sancho‐Puchades Manuel , Hämmerle Christoph H.F. , Jung Ronald Ernst 
Published: June 2021

AbstractObjectivesTo compare free‐hand to computer‐assisted implant planning and placement (CAIPP) regarding planned to achieved implant position.Material and methodsForty‐eight cast/bone models were mounted in mannequin heads. On each side, a tooth gap of different sizes was created. In the test group (T), study implants were placed using a CAD‐CAM guide based on virtual planning. In the control (C), free‐hand implant placement was performed. After CBCT scanning, the implant position was compared with the planned position. Descriptive statistics were applied, and ANOVA was used to identify differences between groups and gaps. (p < .05).ResultsIn C, mean lateral deviations at the implant base amounted to 0.7 mm (max. 1.8) (large gap) and 0.49 mm (1.22) (small gap). In T, 0.18 mm (0.49) and 0.24 mm (0.52) were recorded. At the apex, 0.77 mm (2.04) (large gap) and 0.51 mm (1.24) (small gap) were measured in C, and 0.31 mm (0.83)/0.34 mm (0.93) in T. Mean vertical deviations in C measured 0.46 mm (1.26) (large gap) and 0.45 mm (1.7) (small gap). In T, 0.14 mm (0.44) and 0.28 mm (0.78) were recorded. Mean angular deviations of 1.7° (3.2°) were observed in C (large gap) and 1.36° (2.1°) (small gap). In T, mean values were 1.57° (3.3°) and 1.32° (3.4°). Lateral and vertical deviations were significantly different between groups (not gaps), angular between gaps (not groups).ConclusionsCAIPP protocols showed smaller deviations irrespective of the size of the tooth gap. In C, the gap size had an influence on the error in angulation only.
Calcification sign for prediction of benignity in pulmonary nodules: A meta‐analysis
Authors: Zhou Cheng , Liu Xiao‐Bei , Gan Xiao‐Jing , Li Xing 
Published: June 2021

AbstractBackgroundThe calcification sign assessed by computed tomography appears to be a potential marker for benignities among patients diagnosed with pulmonary nodules (PNs). The following meta‐analysis has been purposefully designed to figure‐out the diagnostic value of the calcification signature as a way of identifying benignities from PNs.MethodsCochrane Library, Embase and PubMed were considered as a reference to obtain the required data from January 2000 until October 2020. Stata v12.0 was used as a standard tool for statistical assessment.ResultsEleven retrospective studies were assessed via this meta‐analysis, which included 6136 PNs (1827 benign and 4309 malignant). The pooled diagnostic odd ratios, positive likelihood ratio (PLR), negative likelihood ratio (NLR), sensitivity and specificity were 6.79, 6.06, 0.89, 13% and 98%, respectively. The value obtained for the area under the curve was 0.65, showing moderate overall diagnostic accuracy. A significant heterogeneity was found while calculating the pooled sensitivity (I2 = 85.5%), specificity (I2 = 75.0%), PLR (I2 = 59.0%), NLR (I2 = 79.5%) and DOR (I2 = 100.0%) in the current analysis. Sub‐group analyses presented better PLR and specificity values for the study with a sample size ≥ 400. Deeks’ funnel plot asymmetry test detected no potential evidence of significant publication bias (p = 0.091).ConclusionsCalcification signs have been identified as moderate regulators corresponding to overall diagnostic performance (via marking a distinct differentiation between malignant and benign) for PNs. However, the manifestation of the calcification sign had a good directive property for benign PNs.
Habitat covariates do not artificially cause a negative correlation between native and non‐native species richness
Authors: Beaury Evelyn M. , Finn John T. , Corbin Jeffrey D. , Bradley Bethany A. 
Published: June 2021

AbstractWhen analyzing biotic resistance/diversity‐invasibility, including predictors of species richness may result in a false negative correlation between native and non‐native richness. However, reanalysis of vegetation surveys shows that the negative effect of native richness is statistically significant whether or not predictors of species richness are included.
Super bowl participation and the local economy: Evidence from the stock market
Authors: Du Rui , Zhang Junfu 
Published: June 2021

AbstractThis paper assesses the impact of a home team's participation in a major sporting event—the Super Bowl—on the local economy. Our identification strategy is to compare the winning and losing cities of the National Football League (NFL) conference championship games under the assumption of similar pre‐trends. We use the stock market performance of public companies headquartered in these cities to capture the changing prospects of local economies attributable to Super Bowl participation. The exogenous variation in football game outcomes allows for a straightforward difference‐in‐differences approach to identify the causal effect. We show that the post‐event trends in winning and losing cities diverge despite their similar trends before the end of the regular season. Our empirical results indicate that winning the NFL conference championship game, thus the opportunity to compete in the Super Bowl, has a positive, significant effect on the local economy, particularly the manufacturing and FIRE (finance, insurance, and real estate) sectors. A similar analysis of winning the Super Bowl, however, finds no further significant effect on the local economy.
Half the V by 120: A practical approach to the prevention of the dialysis disequilibrium syndrome
Authors: Genena Kareem H. , Ahmed Shahbaz , Szerlip Harold M. , Schwartz John C. 
Published: June 2021

AbstractThe dialysis disequilibrium syndrome (DDS) results from osmotic shifts between the blood and the brain compartments. Patients at risk for DDS include those with very elevated blood urea nitrogen, concomitant hypernatremia, metabolic acidosis, and low total body water volumes. By understanding the underlying pathophysiology and applying urea kinetic modeling, it is possible to avoid the occurrence of this disorder. A urea reduction ratio (URR) of no more than 40%–45% over 2 h is recommended for the initial hemodialysis treatment. The relationship between the URR and Kt/V is useful when trying to model the dialysis treatment to a specific URR target. A simplified relationship between Kt/V and URR is provided by the equation: Kt/V = −ln (1 − URR). A URR of 40% is roughly equivalent to a Kt/V of 0.5. The required dialyzer urea clearance to achieve this goal URR in a 120‐min treatment can simply be calculated by dividing half the patient's volume of distribution of urea by 120. The blood flow rate and dialyzer mass transfer coefficient (K0A) required to achieve this clearance can then be plotted on a nomogram. Other methods to reduce the risk of DDS are reviewed, including the use of continuous renal replacement therapy.
ATP/IL‐33‐triggered hyperactivation of mast cells results in an amplified production of pro‐inflammatory cytokines and eicosanoids
Authors: Jordan Paul M. , Andreas Nico , Groth Marco , Wegner Philine , Weber Franziska , Jäger Ute , Küchler Claudia , Werz Oliver , Serfling Edgar , Kamradt Thomas , Dudeck Anne , Drube Sebastian 
Published: June 2021

AbstractIL‐33 and ATP are alarmins, which are released upon damage of cellular barriers or are actively secreted upon cell stress. Due to high‐density expression of the IL‐33 receptor T1/ST2 (IL‐33R), and the ATP receptor P2X7, mast cells (MCs) are one of the first highly sensitive sentinels recognizing released IL‐33 or ATP in damaged peripheral tissues. Whereas IL‐33 induces the MyD88‐dependent activation of the TAK1‐IKK2‐NF‐κB signalling, ATP induces the Ca2+‐dependent activation of NFAT. Thereby, each signal alone only induces a moderate production of pro‐inflammatory cytokines and lipid mediators (LMs). However, MCs, which simultaneously sense (co‐sensing) IL‐33 and ATP, display an enhanced and prolonged activation of the TAK1‐IKK2‐NF‐κB signalling pathway. This resulted in a massive production of pro‐inflammatory cytokines such as IL‐2, IL‐4, IL‐6 and GM‐CSF as well as of arachidonic acid‐derived cyclooxygenase (COX)‐mediated pro‐inflammatory prostaglandins (PGs) and thromboxanes (TXs), hallmarks of strong MC activation. Collectively, these data show that co‐sensing of ATP and IL‐33 results in hyperactivation of MCs, which resembles to MC activation induced by IgE‐mediated crosslinking of the FcεRI. Therefore, the IL‐33/IL‐33R and/or the ATP/P2X7 signalling axis are attractive targets for therapeutical intervention of diseases associated with the loss of integrity of cellular barriers such as allergic and infectious respiratory reactions.