bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of metoclopramide in the first trimester and risk of major congenital malformations: A systematic review and meta-analysis
Authors: Sun Li , Xi Yang , Wen Xiaoke , Zou Wei 
Published: September 2021

Background
Nausea and vomiting of pregnancy affects up to 80% of pregnant women, it typically occurs during the first trimester which is the most sensitive time for environmental exposures given organogenesis. Metoclopramide is an antiemetic drug used widely during NVP, but the findings of studies evaluating its safety of use in pregnancy is inconsistent. Therefore, we conducted a systematic review and meta-analysis to assess whether metoclopramide use during first trimester of pregnancy is associated with the risk of major congenital malformations.

Methods
The systematic search using database included Pubmed, Embase, Web of science, and Cochrane library. Studies written in English, comprising with an exposed group and a control group, reporting major congenital malformation as an outcome were included.

Results
Six studies assessing a total number of 33374 metoclopramide-exposed and 373498 controls infants were included in this meta-analysis. No significant increase in the rate of major congenital malformation was detected following metoclopramide use during first trimester (OR, 1.14; 95% CI, 0.93–1.38).

Conclusions
Metoclopramide use during first trimester of pregnancy was not associated with the risk of major congenital malformations.
Knowledge, attitudes, and practices of face mask utilization and associated factors in COVID-19 pandemic among Wachemo University Students, Southern Ethiopia: A cross-sectional study
Authors: Larebo Yilma Markos , Abame Desta Erkalo 
Published: September 2021

Introduction
The widespread use of face masks by the general public may help to prevent the spread of viruses. Face masks are thought to be a good strategy to protect against respiratory diseases such as the Coronavirus. Identifying student knowledge, attitude, and practice about the use of face masks is crucial to detect vulnerabilities and respond rapidly to avoid the spread of the infection. This study aimed to determine the knowledge, attitude, and practices of face mask utilization and associated factors in the COVID-19 pandemic among college students.

Methods
A cross-sectional study was performed from February to March 2021 among 764 students from Wachemo University, Southern Ethiopia. A multistage sampling technique was used in the study. The sample size for each department was allocated in proportion to the number of students in that department, and each respondent was chosen using a simple random sampling procedure. Data were collected using a pre-tested self-administered questionnaire and analyzed using SPSS version 26. To predict the relationship between the predictor and outcome variables, a logistic regression model was used. At a p-value of 0.05, statistical significance was declared.

Results
The study showed that the overall knowledge of the students was 223 (29.2%), their attitude was 673 (88.1%), and their practice was 684 (89.5%). The students from the college natural and computational sciences (AOR: 0.23; 95%CI: 0.13, 0.40) and students having good knowledge (AOR = 4.40; 95%CI; 2.13, 9.14) were found to be independently associated with face mask utilization.

Conclusion
When compared to other researches, the knowledge about the usage of face masks in this study was low, but the attitudes and practices were high. Authorities in areas that are in danger of a COVID-19 pandemic should plan and implement public awareness and education initiatives.
Pelvic inflammatory disease and causative pathogens in older women in a medical center in eastern Taiwan: A retrospective cross-sectional study
Authors: Chen Pei-Chen , Li Pei-Chen , Ding Dah-Ching 
Published: September 2021

ObjectivesMost research into the management of pelvic inflammatory disease (PID) is in younger women and focuses on sexually transmitted pathogens such asN.gonorrhoeaeorC.trachomatis. Non-sexually transmitted bacterial pathogens and PID in older women are rarely examined. The objective of this study is to explore cervical culture pathogens in women of different age groups in a medical center in eastern Taiwan.MethodsWe enrolled patients whose medical records were diagnosed with PID (ICD-9-CM 614.0 [N70.01–03], 614.1[N70.11–13], 614.9 [N73.5, N73.9]) at our hospital from October 2014 to March 2020. Patients were divided into three groups according to age: the age <25 years, age 25–44 years, and the ≥ 45 years group. Chi-square test, ANOVA and logistic regression were used for statistical analysis. In subgroup analysis, endocervical pathogens were further stratified into vaginal, respiratory, enteric, skin, oral, and other.ResultsA total of 96 patients were included in the study. There were 31 patients in the age ≥ 45 years group, 52 patients in the age 25–44 years group, and 13 patients in the age <25 years group. Vagina and enteric pathogens were the most common pathogens among all groups. The isolated respiratory and other pathogens were more in the age ≥ 45 years group than in the other two groups.Prevotella biviawas more common in the age <25 years and 25–44 years groups.ConclusionsThis may be due to different pathogeneses of PID in the age ≥ 45 years patients. Our study can be used as a reference for antibiotic choice of non-sexually transmitted PID and to prevent long-term sequelae of PID.
The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis
Authors: Bisetegn Habtye , Ebrahim Hussien 
Published: September 2021

Introduction
Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV/AIDS patients.

Methods
This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle—Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia.

Result
Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40–11.97%). Significant heterogeneity was observed with I2 value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV/AIDS patients was 17.31% (95%CI: 12.37–22.25%).

Conclusion
This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment.
Cross-sectional study of approaches to diagnosis and management of dogs with immune-mediated haemolytic anaemia in primary care and referral veterinary practices in the United Kingdom
Authors: Swann James W. , Tayler Sarah , Hall Harriet , Sparrow Richard , Skelly Barbara J. , Glanemann Barbara 
Published: September 2021

Objectives
To determine whether veterinarians in primary care practices (PCPs) and board-certified clinicians (BCCs) approach treatment of dogs with immune-mediated haemolytic anaemia (IMHA) similarly, and whether practitioners with more experience treat similarly to those with less experience. We hypothesised those in PCPs would show more variation in their approach to similar cases than BCCs.

Methods
A cross-sectional study was conducted by distributing a questionnaire to BCCs and veterinarians in PCPs. The questionnaire included direct questions and a number of clinical scenarios intended to capture approaches to common treatment problems.

Results
Questionnaire responses were received from 241 veterinarians, including 216 in PCPs and 25 BCCs. Veterinarians in both settings used similar tests for diagnosis of IMHA, but BCCs performed more tests to exclude underlying causes of ‘associative’ disease. All veterinarians reported use of similar initial dosages of glucocorticoids (median 2 mg/kg per day in both groups, p = 0.92) but those used by more experienced practitioners were higher than those with less experience. Most veterinarians made allowances for the weight of dogs, using lower prednisolone dosages in a clinical scenario involving a 40 kg dog compared to a 9 kg dog (p = 0.025 for PCP, p = 0.002 for BCC). BCCs reported greater use of combinations of immunosuppressive drugs (p<0.0001) and of antithrombotic drugs (p<0.0001); use of antithrombotic drugs was also less common among more experienced practitioners compared to less experienced.

Conclusions
Approaches to treatment of dogs with IMHA differ between BCCs and those in PCP. These differences may affect design and implementation of future research studies and clinical guidelines.
Digital preferences and perceptions of students in health professional courses at a leading Australian university: A baseline for improving digital skills and competencies in health graduates
Authors: Cham Kwang , Edwards Mary-Louise , Kruesi Lisa , Celeste Tania , Hennessey Trent 
Published: September 2021

This study aimed to improve understanding of graduate students’ digital preferences and perceptions to prepare them for work in the digitally enabled health sector. We surveyed 361 students from five disciplines to create a baseline of their digital capabilities. Results show that students were confident in engaging with day-to-day technologies required for discipline-specific learnings and most were reasonably aware of digital privacy and security. However, only 11% of the students reported having sufficient university support and services to develop their digital skills and competencies, and only 39% of the students believed they have the relevant skills for entering the workforce. To improve their understanding in this area, students attended a digital skills and employability workshop that was developed in partnership with teaching specialists, learning and teaching librarians and career services coordinators. Post-workshop findings show that this learning intervention positively impacted students’ understanding of their own digital capabilities and increased their awareness of the importance of this core skill for both the university and the workforce. Teaching staff can use these findings to improve student digital learning in health professional curricula, which will contribute to knowledge transfer and communication with digital health employers.
Implications for practice or policy:

Heath professional educators can bridge the gap in digital practices between graduates and the workplace by understanding students’ baseline digital skills and competencies and developing targeted learning opportunities within the curriculum to support students’ digital confidence, experience, attitudes and understandings of digital practices and digital skills and competencies.
Students’ digital skills and competencies can be enhanced by facilitating dialogue between universities, employers and accrediting bodies in the health sector to set consistent and realistic expectations.
Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
Authors: Altir Najah Khalifah Mansour , Ali Ammar Mohammed Ahmed , Gaafar Abdel-Rhman Z. , Qahtan Ahmed A. , Abdel-Salam Eslam M. , Alshameri Aref , Hodhod Mohamed S. , Almunqedhi Bander 
Published: September 2021

Abstract

Curcuma longa L. is a famous spice cultivated in many countries with significant variations reported in its phytochemical contents and biological potential. For the first time, the present work is aimed to identify the major phytochemicals present in methanol:chloroform (MC) and petroleum ether (PE) extracts of Curcuma longa rhizome and leaves (by determining polyphenols and GC/MS analysis), and their in-vitro antioxidant and anti-protein denaturation potential. Results showed that the highest value (P < 0.05) of polyphenolic content was in MC extract of rhizome (51.46 ± 0.46 mg GAE/g) followed by 31.20 ± 0.53 mg GAE/g in MC leaves extract. The strong antiradical activity was evaluated in MC extract of rhizome with IC50 value of 92 ± 0.02 µg/mL. MC extracts of both the rhizome and leaves exerted a potent inhibitory effect against protein denaturation with IC50 values of 106.21 ± 0.53 and 108.06 ± 4.67 μg/mL (P > 0.5), respectively. GC/MS analysis showed that α-tumerone was the main component in the rhizome oil (32.44%), whereas in the leaf oil, palmitic acid was the prominent constituent (28.33%) and α-phellandrene recorded a comparable percentage (7.29). In conclusion, C. longa is a valuable source of natural antioxidants and anti-inflammatory constituents, as indicated by its high polyphenolic content and by its considerable in vitro antiradical and anti-protein denaturation potential.
Isomorphism classification of Leary–Minasyan groups
Authors: Valiunas Motiejus 
Published: September 2021

Abstract
Recently, I. J. Leary and A. Minasyan [Commensurating HNN extensions: Nonpositive curvature and biautomaticity, Geom. Topol.
25 (2021), 4, 1819–1860] studied the class of groups

G
⁢

(
A
,
L
)

G(A,L)

defined as commensurating HNN-extensions of

Z
n

\mathbb{Z}^{n}

.
This class, containing the class of Baumslag–Solitar groups, also includes other groups with curious properties, such as being CAT(0) but not biautomatic.
In this paper, we classify the groups

G
⁢

(
A
,
L
)

G(A,L)

up to isomorphism.
The ambiguous sea level rise at Brest’s 212 yearlong record elucidated
Authors: İz H. Bâki , Shum C.K. 
Published: September 2021

Abstract
The tide gauge record at Brest, France, along Eastern part of Atlantic coast is one of the longest records in Europe spanning 212 years (1807–2019). Analyzing these records has important ramifications in assessing anthropogenic impact of climate change at local and regional scales during this period. All the previous studies that analyzed Brest’s tide gauge record have used vaguely defined quadratics models and did not incorporate the effect of sea level variations at various frequencies, which confounded the presence or absence of a plausible uniform acceleration. Here, we entertained two competing kinematic models; one with a uniform acceleration representing 212 years of monthly averaged tide gauge data, the other is a two-phase trend model (Phase I is 93 years long and Phase II is 119 years long). Both models include statistically significant (α = 0.05) common periodic effects, and sub and super harmonics of luni-solar origin for representing monthly averaged sea level anomalies observed at Brest. The least squares statistics for both models’ solutions cannot distinguish one model over the other, like earlier studies. However, the assessment of Phase I segment of the records disclosed the absence of a statistically significant trend and a uniform acceleration during this period. This outcome eliminates conclusively the occurrence of a uniform acceleration during the entire 212-year data span of the tide gauge record at Brest, favoring the two-phase trend model as a sound alternative.
Hearing and Listening in the Context of Passivity and Activity
Authors: Zelenka Jiří 
Published: September 2021

AbstractThe aim of this article is to demonstrate the phenomenologically grounded dynamics of hearing and listening as a possible approach to our sonic experience. Its starting point is the studies of contemporary urban spaces devoted to their sonic experience. The results of these studies and their interpretation will serve as a starting point for the introduction of dynamics of hearing and listening. In the next part of this article, I will focus on the elaboration of this relationship with regard to the critique of Husserl’s concept of activity and passivity in his late workExperience and Judgmentand Merleau-Ponty’s concept of being-in-the-world. Based on this, in the end, certain common features will be shown, connecting the thematization of activity and passivity with the relationship of hearing and listening.
Cephradine drug release using electrospun chitosan nanofibers incorporated with halloysite nanoclay
Authors: Naz Mahwish , Rizwan Muhammad , Jabeen Sehrish , Ghaffar Abdul , Islam Atif , Gull Nafisa , Rasool Atta , Khan Rafi Ullah , Alshawwa Samar Z. , Iqbal Munawar 
Published: September 2021

Abstract
The chitosan/polyvinyl alcohol/halloysite nanoclay (CS/PVA/HNC) loaded with cephradine drug electrospun nanofibers (NFs) were fabricated and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) techniques. FTIR analysis confirmed the hydrogen bonding between the polymer chain and the developed siloxane linkages. SEM analysis revealed the formation of uniform NFs having beads free and smooth surface with an average diameter in 50–200 nm range. The thermal stability of the NFs was increased by increasing the HNC concentration. The antimicrobial activity was examined against Escherichia
coli and staphylococcus strains and the NFs revealed auspicious antimicrobial potential. The drug release was studied at pH 7.4 (in PBS) at 37 °C. The drug release analysis showed that 90% of the drug was released from NFs in 2 h and 40 min. Hence, the prepared NFs could be used as a potential drug carrier and release in a control manner for biomedical application.
High Behavioral Variability Mediated by Altered Neuronal Excitability inauts2Mutant Zebrafish
Authors: Jha Urvashi , Kondrychyn Igor , Korzh Vladimir , Thirumalai Vatsala 
Published: September 2021

AbstractAutism spectrum disorders (ASDs) are characterized by abnormal behavioral traits arising from neural circuit dysfunction. While a number of genes have been implicated in ASDs, in most cases, a clear understanding of how mutations in these genes lead to circuit dysfunction and behavioral abnormality is absent. Theautism susceptibility candidate 2(AUTS2) gene is one such gene, associated with ASDs, intellectual disability and a range of other neurodevelopmental conditions. However, the role of AUTS2 in neural development and circuit function is not at all known. Here, we undertook functional analysis of Auts2a, the main homolog of AUTS2 in zebrafish, in the context of the escape behavior. Escape behavior in wild-type zebrafish is critical for survival and is therefore, reliable, rapid, and has well-defined kinematic properties.auts2amutant zebrafish are viable, have normal gross morphology and can generate escape behavior with normal kinematics. However, the behavior is unreliable and delayed, with high trial-to-trial variability in the latency. Using calcium imaging we probed the activity of Mauthner neurons during otic vesicle (OV) stimulation and observed lower probability of activation and reduced calcium transients in the mutants. With direct activation of Mauthner by antidromic stimulation, the threshold for activation in mutants was higher than that in wild-type, even when inhibition was blocked. Taken together, these results point to reduced excitability of Mauthner neurons inauts2amutant larvae leading to unreliable escape responses. Our results show a novel role for Auts2a in regulating neural excitability and reliability of behavior.
Studying IndependentKcna6Knock-out Mice Reveals Toxicity of Exogenous LacZ to Central Nociceptor Terminals and Differential Effects of Kv1.6 on Acute and Neuropathic Pain Sensation
Authors: Peck Liam J. , Patel Ryan , Diaz Paula , Wintle Yolanda M. , Dickenson Anthony H. , Todd Andrew J. , Calvo Margarita , Bennett David L.H. 
Published: September 2021

The potassium channel Kv1.6 has recently been implicated as a major modulatory channel subunit expressed in primary nociceptors. Furthermore, its expression at juxtaparanodes of myelinated primary afferents is induced following traumatic nerve injury as part of an endogenous mechanism to reduce hyperexcitability and pain-related hypersensitivity. In this study, we compared two mouse models of constitutive Kv1.6 knock-out (KO) achieved by different methods: traditional gene trap via homologous recombination and CRISPR-mediated excision. Both Kv1.6 KO mouse lines exhibited an unexpected reduction in sensitivity to noxious heat stimuli, to differing extents: the Kv1.6 mice produced via gene trap had a far more significant hyposensitivity. These mice (Kcna6lacZ) expressed the bacterial reporter enzyme LacZ in place of Kv1.6 as a result of the gene trap mechanism, and we found that their central primary afferent presynaptic terminals developed a striking neurodegenerative phenotype involving accumulation of lipid species, development of “meganeurites,” and impaired transmission to dorsal horn wide dynamic range neurons. The anatomic defects were absent in CRISPR-mediated Kv1.6 KO mice (Kcna6−/−) but were present in a third mouse model expressing exogenous LacZ in nociceptors under the control of a Nav1.8-promoted Cre recombinase. LacZ reporter enzymes are thus intrinsically neurotoxic to sensory neurons and may induce pathologic defects in transgenic mice, which has confounding implications for the interpretation of gene KOs usinglacZ. Nonetheless, inKcna6−/−mice not affected by LacZ, we demonstrated a significant role for Kv1.6 regulating acute noxious thermal sensitivity, and both mechanical and thermal pain-related hypersensitivity after nerve injury.SIGNIFICANCE STATEMENTIn recent decades, the expansion of technologies to experimentally manipulate the rodent genome has contributed significantly to the field of neuroscience. While introduction of enzymatic or fluorescent reporter proteins to label neuronal populations is now commonplace, often potential toxicity effects are not fully considered. We show a role of Kv1.6 in acute and neuropathic pain states through analysis of two mouse models lacking Kv1.6 potassium channels: one with additional expression of LacZ and one without. We show that LacZ reporter enzymes induce unintended defects in sensory neurons, with an impact on behavioral data outcomes. To summarize we highlight the importance of Kv1.6 in recovery of normal sensory function following nerve injury, and careful interpretation of data from LacZ reporter models.