bluuebunny/crossref_metadata_2025_split huggingface dataset:
Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study
Authors: Li Jianqiao , Hojlo Margaret A , Chennuri Sampath , Gujral Nitin , Paterson Heather L , Shefchek Kent A , Genetti Casie A , Cohn Emily L , Sewalk Kara C , Garvey Emily A , Buttermore Elizabeth D , Anderson Nickesha C , Beggs Alan H , Agrawal Pankaj B , Brownstein John S , Haendel Melissa A , Holm Ingrid A , Gonzalez-Heydrich Joseph , Brownstein Catherine A 
Published: March 2021

Background
16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental and physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use a patient “self-phenotyping” survey to collect data directly from patients to further characterize the phenotypes of 16p13.11 microduplication syndrome.

Objective
This study aimed to (1) discover self-identified phenotypes in 16p13.11 microduplication syndrome that have been underrepresented in the scientific literature and (2) demonstrate that self-phenotyping tools are valuable sources of data for the medical and scientific communities.

Methods
As part of a large study to compare and evaluate patient self-phenotyping surveys, an online survey tool, Phenotypr, was developed for patients with rare disorders to self-report phenotypes. Participants with 16p13.11 microduplication syndrome were recruited through the Boston Children's Hospital 16p13.11 Registry. Either the caregiver, parent, or legal guardian of an affected child or the affected person (if aged 18 years or above) completed the survey. Results were securely transferred to a Research Electronic Data Capture database and aggregated for analysis.

Results
A total of 19 participants enrolled in the study. Notably, among the 19 participants, aggression and anxiety were mentioned by 3 (16%) and 4 (21%) participants, respectively, which is an increase over the numbers in previously published literature. Additionally, among the 19 participants, 3 (16%) had asthma and 2 (11%) had other immunological disorders, both of which have not been previously described in the syndrome.

Conclusions
Several phenotypes might be underrepresented in the previous 16p13.11 microduplication literature, and new possible phenotypes have been identified. Whenever possible, patients should continue to be referenced as a source of complete phenotyping data on their condition. Self-phenotyping may lead to a better understanding of the prevalence of phenotypes in genetic disorders and may identify previously unreported phenotypes.
A Smartphone App to Restore Optimal Weight (SPAROW) in Women With Recent Gestational Diabetes Mellitus: Randomized Controlled Trial
Authors: Lim Karen , Chan Shiao-Yng , Lim Su Lin , Tai Bee Choo , Tsai Cammy , Wong Su Ren , Ang Siew Min , Yew Tong Wei , Tai E Shyong , Yong Eu Leong 
Published: March 2021

Background
Women with a history of gestational diabetes mellitus (GDM) are at an increased risk of developing type 2 diabetes mellitus (T2DM). Lifestyle interventions aimed at postpartum weight loss to reduce T2DM risk have been reported, but poor compliance remains a barrier. Smartphone-based interventions may improve compliance, but data on its use in women with recent GDM are limited.

Objective
This trial aimed to investigate the efficacy of a smartphone app in restoring optimal weight following delivery in women with GDM, in the setting of a population with high rates of GDM and type 2 diabetes.

Methods
In this unblinded randomized controlled trial, 200 women with GDM were randomized to receive the intervention or standard care following delivery. The intervention enabled logging of weight, meals, and activity, with web-based interaction with a team comprising dieticians, a physiotherapist, and an occupational therapist. The primary outcome was an achievement of optimal weight (defined as the restoration of first trimester weight if first trimester BMI≤23 kg/m2 or weight loss of at least 5% from first trimester weight if first trimester BMI>23 kg/m2) at 4 months post partum. Secondary outcome measures included absolute weight loss, serum metabolic markers, self-reported nutritional intake, health education, and quality of life via questionnaires and user engagement in the intervention group.

Results
In total, 40% (38/96) of women in the intervention group achieved optimal weight at 4 months post delivery compared with 32% (28/93) in the control group (P=.27). Compared with the control group, women in the intervention group reported significantly reduced caloric intake at 4 months after delivery (P<.001) and higher health-directed behavior scores (P=.045). The intervention group also reported increased emotional distress scores (P=.01). At 4 months, participant engagement with the intervention was maintained at 60.8% (SD 33.9%).

Conclusions
Although a statistically significant increase in women achieving healthy weight was not observed, this app remains promising, as women in the intervention group reported improved health behaviors and lower caloric intake. Importantly, the high retention rates suggest that a larger study with a longer follow-up period might confirm the effectiveness of this app for weight management.

Trial Registration
ClinicalTrials.gov NCT03324737; https://clinicaltrials.gov/ct2/show/NCT03324737

International Registered Report Identifier (IRRID)
RR2-10.1186/s12889-019-7691-3
A Web-Based Group Cognitive Behavioral Therapy Intervention for Symptoms of Anxiety and Depression Among University Students: Open-Label, Pragmatic Trial
Authors: Bantjes Jason , Kazdin Alan E , Cuijpers Pim , Breet Elsie , Dunn-Coetzee Munita , Davids Charl , Stein Dan J , Kessler Ronald C 
Published: March 2021

Background
Anxiety and depression are common among university students, and university counseling centers are under pressure to develop effective, novel, and sustainable interventions that engage and retain students. Group interventions delivered via the internet could be a novel and effective way to promote student mental health.

Objective
We conducted a pragmatic open trial to investigate the uptake, retention, treatment response, and level of satisfaction with a remote group cognitive behavioral therapy intervention designed to reduce symptoms of anxiety and depression delivered on the web to university students during the COVID-19 pandemic.

Methods
Preintervention and postintervention self-reported data on anxiety and depression were collected using the Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9. Satisfaction was assessed postintervention using the Client Satisfaction with Treatment Questionnaire.

Results
A total of 175 students were enrolled, 158 (90.3%) of whom initiated treatment. Among those initiating treatment, 86.1% (135/158) identified as female, and the mean age was 22.4 (SD 4.9) years. The mean number of sessions attended was 6.4 (SD 2.8) out of 10. Among participants with clinically significant symptoms at baseline, mean symptom scores decreased significantly for anxiety (t56=11.6; P<.001), depression (t61=7.8; P<.001), and composite anxiety and depression (t60=10.7; P<.001), with large effect sizes (d=1-1.5). Remission rates among participants with clinically significant baseline symptoms were 67.7%-78.9% and were not associated with baseline symptom severity. High overall levels of satisfaction with treatment were reported.

Conclusions
The results of this study serve as a proof of concept for the use of web-based group cognitive behavioral therapy to promote the mental health of university students.
Feeding habitat of the understory arboreal snail Tikoconus costarricanus (Stylommatophora: Euconulidae) in a tropical montane wet forest, Costa Rica
Authors: Barrientos Zaidett 
Published: March 2021

Introduction: The feeding habitats of land snails are essential for their survival. Some are little known, for example the upper surface of leaves, habitat of tropical arboreal and shrub snails. Objective: To analyze the feeding behavior and preferences in the feeding habitat of the tropical snail Tikoconus costarricanus. Methods: In a humid montane tropical forest in Cartago, Costa Rica, I recorded every 3 to 4 hours the feeding activity and general behavior of individually marked snails on a 2km trail (seven 24-hour visits in May 2010-March 2011). Results: I observed a total of 167 individual specimens and made 781 observations about their behavior and the leaves on which they were found. These snails preferred monocotyledonous leaves with many epiphylls, despite the fact that those leaves were not common in this forest. They avoided ferns, and during the less rainy season, they preferred leaves with many trichomes, although there were few such leaves. On average, they spent 11 hours on each individual leaf and visited two leaves per day. The few snails seen on stems were almost always moving, as opposed to those on the leaf underside. On average they moved a net 65 cm each day. Feeding concentrated around 9:00 am and defecation around 4:20 am. Conclusions: These snails prefer leaves with many epiphylls, where they find good camouflage, moisture and food. The preference for trichomes could be due to mechanical reasons. The lack of seasonality in their behavior may reflect their stable food source in a forest that remains humid year round.
IMPROVING STUDENTS’ VOCABULARY MASTERY TROUGH SNOWING BALL IN DESCRIPTIVE TEXT
Authors: Azizah Nur , Fadloeli Odo 
Published: March 2021

The objective of this research study was to show how to improve the student’s vocabulary through snowing ball. Snowing ball is a way of presenting learning materials where students are formed in several heterogeneous groups to make a vocabulary. The data were obtained by the teaching and learning process, and analyze the student assessment results. The data collected were quantitative. The data analyzed from the control class value and experiment class value. The result of this research was showed the snowing ball method that used on this research will increase the average students’ score by 86%. It mean the snowing ball method on the control class is successful to improving the students’ vocabulary mastery. It also means the snowing ball method was successful to improve the student’s vocabulary. Keywords: Vocabulary, Snowing Ball, Improvement.
SLIP OF THE TONGUE IN BARACK OBAMA INTERVIEW AT THE AXE FILE
Authors: Zulaihah Siti , Indah Rohmani Nur 
Published: March 2021

This study examines the type of slip of the tongue in Barack Obama's interview at The Axe Files. It also analyzes the possible factors causing the error in speech production in the context of political discourse. It used Fromkin’s and Clark’s theories to investigate the audio data on The Axe File episode 108 and 288 published in 2016 and 2018. The result shows that Obama employed anticipation, perseveration, transposition, substitution, blend, and haplologies. The dominant type produced in the interview is substitution. In addition, the factors influencing slip production are cognitive difficulty, situational anxiety, and social factors. These findings can be a reference for EFL teachers to show the various type of speech error produced in political discourses by native speakers. Further researchers are expected to use other relevant theories to classify a slip of the tongue in several other contexts.
IMPROVING STUDENTS’ WRITING DESCRIPTIVE TEXT THROUGH THINK-PAIR-SHARE TECHNIQUE
Authors: Febriyantika Rika , Parmawati Aseptiana 
Published: March 2021

Writing is troublesome to be learned and taught for some students. One technique that can be used in teaching writing is TPS. The research was conducted in SMP Plus Nurulhidayah Pasundan. The researchers identify some problems, such as: 1) Does teaching writing using TPS improve the students’ writing creativity?, 2) How is the teaching and learning situation when TPS implemented in the writing class?. Classroom Action Research was used in this research. From the result of pre-test, we found that the result of students’ writing was under average and still far from what was expected. The finding was supported by the result of students’ writing scores. The average score of pre test was 47.1. After the implementation of TPS activities in every cycle, the students’ writing score were getting better. It can be seen from the result of students’ average score Cycle 1 was 51.8 and Cycle 2 was 71.09 It can be concluded that TPS can improve students’ writing creativity and TPS can improve writing classroom into a better situation. Keywords: Think Pair Share, Writing Skill, CAR
From Arctic Science to Global Policy – Addressing Multiple Stressors Under the Stockholm Convention
Authors: Steindal Eirik Hovland , Karlsson Marianne , Hermansen Erlend A. T. , Borch Trude , Platjouw Froukje Maria 
Published: March 2021

Rapid climate change in the Arctic triggers the remobilization of chemical pollution, increasing its exposure and potential impacts in the region. While scientific knowledge on multiple stressors, including the interlinkages between climate change and hazardous chemicals, is increasing, it has proven challenging to translate this knowledge into policy. This study analyzes the process of translating Arctic scientific knowledge on multiple stressors into global policy by focusing on the development of a guidance document under the Stockholm Convention on Persistent Organic Pollutants (POPs). Through document analysis and key informant interviews, we focus particularly on the role of the Arctic Council working group AMAP in synthesizing, translating and communicating science on multiple stressors to policy makers. We draw on the theoretical framework of formalization (how and by whom knowledge is summarized for policy) and separation (the relative distance between science and policy) to analyze the science-to-policy interface. Our analysis of the phases leading up to the guidance document show that AMAP has dynamically moved between different degrees of separation and formalization. Orchestrating the interplay between scientists and policy makers, the working group has put multiple stressors on the political agenda internationally. AMAP has thereby contributed to turn Arctic science into global policy through the guidance document. We conclude by illustrating several constraints in terms of the implementation of actual policy, which we argue is due to an increasing degree of formalization in the last phase and a general unreadiness of contemporary governance systems to address multiple stressors.
Maximizing Bali Village Tourism Potential Using Penta-Helix Model
Authors: Novianti Khusnul Rofida 
Published: March 2021

The rapid growth of the tourism sector has made the government committed to implementing the principle of sustainable tourism development. To develop regional tourism, it is relatively necessary to direct, integrated, cross-sectoral, and sustainable programs so that the economic benefits of tourism are increasingly felt evenly distributed by the community. Bali, popular as one of the most tourist destinations in the world, is used as an example for the development of a national destination by the Indonesian government by creating 10 new Bali destinations, but this scheme must be postponed due to the covid-19 outbreak that hit Indonesia. This study aims to explore the sustainable tourism strategy in Bali’s village tourism sector using a qualitative approach based on content analysis based on secondary data since Bali has the largest number of village tourism in Indonesia using the Penta-helix model (synergy between academic, business, community, government, and media). With the synergy and collaboration of these five central sectors (especially during decreasing tourism sector of coronavirus outbreak), it is expected to increase awareness and maximizing the potential among the public regarding Bali sustainable tourism.
КОМПЕТЕНТНІСНИЙ ПІДХІД ТА ЙОГО ЗНАЧЕННЯ В ФОРМУВАННІ ПРОФЕСІЙНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ БАКАЛАВРІВ ГОТЕЛЬНО-РЕСТОРАННОЇ СПРАВИ
Authors: Дмитренко Генадій , Каролоп Олена 
Published: March 2021

У статті розглянуто зміст компетентнісного потенціалу освітнього процесу, обґрунтовано актуальність його створення та реалізації в освітній практиці. Охарактеризовано, проаналізовано й доповнено понятійну систему. Визначено структурні компоненти компетентнісного потенціалу.
Сьогодні суспільство вимагає від системи вищої освіти професійної підготовки майбутніх бакалаврів готельно-ресторанної справи, що володіють сучасними, фундаментальними знаннями, вміннями та навичками, здатних творчо підходити до розв’язання неординарних питань, бути конкурентоспроможними на ринку праці. Тому одним із чергових завдань вищої освіти є питання впровадження компетентнісного підходу у професійну підготовку студентів. Основна увага акцентується на компетенціях, що сприяють адаптації фахівців до мінливих умов сучасного ринку праці готельно-ресторанної індустрії й бурхливого розвитку науки й техніки.
SOSIALISASI DAN INSTALASI ALAT UNTUK MENGKONVERSI LIMBAH TANAMAN MENJADI BIOGAS SEBAGAI BAHAN BAKAR KOMPOR GAS DENGAN CARA SEDERHANA
Authors: Sitaresmi Ratnayu , Fathaddin M. Taufiq , Widiatni Harin , Ridaliani Onnie , Mega Lia 
Published: March 2021

Pengabdian Kepada Masyarakat untuk tahap ketiga ini merupakan sosialisasi pemasangan alat untuk pembuatan biogas dari tanaman untuk menghidupkan kompor. Sosialisasi kepada masyarakat, khususnya kepada para ibu penggerak kader pedesaan dan anggota Pembinaan Kesejahteraan Keluarga (PKK), karena daerah tersebut tergolong kurang mendapat informasi tentang pemanfaatan limbah tanaman untuk menjadi biogas. Tujuan dari sosialisasi ini adalah agar masyarakat setempat dapat memanfaatkan limbah tanaman dalam pembuatan biogas, karena minyak maupun gas yang dibeli dari Pertamina dengan harga yang semakin mahal, membuat masyarakat di daerah tersebut berkeinginan mengetahui cara mengupayakan energi alternatif yang berasal dari limbah tanaman. Peserta sosialisasi sangat antusias untuk membuktikan bahwa alat biogas yang telah disosialisasikan selama ini dapat dimanfaatkan untuk membuat gas metana (CH4) dari limbah tanaman. Pembusukan limbah tanaman dapat menghasilkan gas metana (CH4) yang dapat digunakan untuk menghidupkan kompor gas untuk kebutuhan rumah tangga, sehingga diharapkan dapat berfungsi maksimal menggantikan bahan bakar kompor gas yang digunakan selama ini, baik dengan bahan bakar minyak maupun gas yang berasal dari energi fosil.
A Robust Method to Predict Fluid Properties Based on Big Data and Machine Learning Algorithms
Authors: Liu Yingxian , Chen Cunliang , Zhao Hanqing , Wang Yu , Han Xiaodong 
Published: March 2021

Abstract
Fluid properties are key factors for predicting single well productivity, well test interpretation and oilfield recovery prediction, which directly affect the success of ODP program design. The most accurate and direct method of acquisition is underground sampling. However, not every well has samples due to technical reasons such as excessive well deviation or high cost during the exploration stage. Therefore, analogies or empirical formulas have to be adopted to carry out research in many cases. But a large number of oilfield developments have shown that the errors caused by these methods are very large. Therefore, how to quickly and accurately obtain fluid physical properties is of great significance.
In recent years, with the development and improvement of artificial intelligence or machine learning algorithms, their applications in the oilfield have become more and more extensive. This paper proposed a method for predicting crude oil physical properties based on machine learning algorithms. This method uses PVT data from nearly 100 wells in Bohai Oilfield. 75% of the data is used for training and learning to obtain the prediction model, and the remaining 25% is used for testing. Practice shows that the prediction results of the machine learning algorithm are very close to the actual data, with a very small error. Finally, this method was used to apply the preliminary plan design of the BZ29 oilfield which is a new oilfield. Especially for the unsampled sand bodies, the fluid physical properties prediction was carried out. It also compares the influence of the analogy method on the scheme, which provides potential and risk analysis for scheme design. This method will be applied in more oil fields in the Bohai Sea in the future and has important promotion value.
Periodic discharges with high frequency oscillations recorded from a cerebellar gangliocytoma in an epileptic infant
Authors: Mukae Nobutaka , Morioka Takato , Torio Michiko , Sakai Yasunari , Shimogawa Takafumi , Sakata Ayumi , Suzuki Satoshi O. , Mizoguchi Masahiro 
Published: March 2021

Background:
Subcortical epilepsies associated with developmental tumors in the cerebellum are rarely experienced. As supportive evidence of the intrinsic epileptogenicity of cerebellar tumors, previous electroencephalogram (EEG) studies with intratumoral depth electrodes demonstrated epileptiform or ictal discharges. Recent studies have demonstrated that high frequency oscillations (HFOs) can be regarded as a new biomarker of epileptogenesis and ictogenesis; however, there are few evidence about HFOs in cases of epilepsy associated with cerebellar tumors.

Case Description:
A 6-month-old Japanese male infant presented to our hospital with drug resistant epilepsy. We underwent subtotal resection of a cerebellar gangliocytoma and obtained good seizure outcomes. Intraoperative EEG in the tumor depicted HFOs in the form of ripples, riding on periodic discharges.

Conclusion:
Our findings provide further supportive evidence for the intrinsic epileptogenicity of cerebellar tumors.
Fusion for subaxial bow hunter’s syndrome results in remote osseous remodeling of the hyperostotic growth responsible for vertebral artery compression
Authors: Ikeda Daniel Satoshi , Miller Charles A. , Ravindra Vijay M. 
Published: March 2021

Background:
The authors present a previously unreported case of a patient with diffuse idiopathic skeletal hyperostosis (DISH) who developed bow hunter’s syndrome (BHS) or positional vertebrobasilar insufficiency. In addition, the authors demonstrate angiographic evidence of remote osseous remodeling after segmental fusion without direct decompression of the offending bony growth. BHS is a rare, yet well established, cause of posterior circulation ischemia and ischemic stroke. Several etiologies such as segmental instability and spondylosis have been described as causes, however, DISH has not been associated with BHS before this publication.

Case Description:
A 77-year-old man who presented with BHS was found to have cervical spine changes consistent with DISH, and angiography confirmed right vertebral artery (VA) stenosis at C4–5 from a large pathological elongation of the right C5 lateral mass. Head rotation resulted in occlusion of the VA. The patient underwent an anterior cervical discectomy and fusion and reported complete resolution of his symptoms. A delayed angiogram and CT of the cervical spine demonstrated complete resolution of the baseline stenosis, no dynamic compression, and remote osseous remodeling of the growth, respectively.

Conclusion:
This case represents the first publication in the literature of DISH as a causative etiology of BHS and of angiographic data demonstrating resolution of a compressive osseous pathology without direct decompression in BHS.