bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detrital zircon petrochronology of central Australia, and implications for the secular record of zircon trace element composition
Authors: Verdel Charles , Campbell Matthew J. , Allen Charlotte M. 
Published: February 2021

AbstractHafnium (Hf) isotope composition of zircon has been integrated with U-Pb age to form a long-term (&gt;4 b.y.) record of the evolution of the crust. In contrast, trace element compositions of zircon are most commonly utilized in local- or regional-scale petrological studies, and the most noteworthy applications of trace element studies of detrital zircon have been in “fingerprinting” potential source lithologies. The extent to which zircon trace element compositions varied globally over geological time scales (as, for example, zircon U-Pb age abundance, O isotope composition, and Hf isotope composition seem to have varied) has been little explored, and it is a topic that is well suited to the large data sets produced by detrital zircon studies. In this study we present new detrital zircon U-Pb ages and trace element compositions from a continent-scale basin system in Australia (the Centralian Superbasin) that bear directly on the Proterozoic history of Australia and which may be applicable to broader interpretations of plate-tectonic processes in other regions. U-Pb ages of detrital zircon in the Centralian Superbasin are dominated by populations of ca. 1800, 1600, 1200, and 600 Ma, and secular variations of zircon Hf isotope ratios are correlated with some trace element parameters between these major age populations. In particular, elevated εHf(i) (i.e., radiogenic “juvenile” Hf isotope composition) of detrital zircon in the Centralian Superbasin tends to correspond with relatively high values of Yb/U, Ce anomaly, and Lu/Nd (i.e., depletion of light rare earth elements). These correlations seem to be fundamentally governed by three related factors: elemental compatibility in the continental crust versus mantle, the thickness of continental crust, and the contributions of sediment to magmas. Similar trace element versus εHf(i) patterns among a global zircon data set suggest broad applicability. One particularly intriguing aspect of the global zircon data set is a late Neoproterozoic to Cambrian period during which both zircon εHf(i) and Yb/U reached minima, marking an era of anomalous zircon geochemistry that was related to significant contributions from old continental crust.
Along-strike variations in protothrust zone characteristics at the Nankai Trough subduction margin
Authors: Tilley Hannah L. , Moore Gregory F. , Yamashita Mikiya , Kodaira Shuichi 
Published: February 2021

AbstractSignificant along-strike changes in the protothrust zone at the toe of the Nankai Trough accretionary prism were imaged in new high-resolution seismic reflection data. The width of the protothrust zone varies greatly along strike; two spatially discrete segments have a wide protothrust zone (∼3.3–7.8 km, ∼50–110 protothrusts), and two segments have almost no protothrust zone (∼0.5–2.8 km, &lt;20 protothrusts). The widest protothrust zone occurs in the region with the widest and thickest sediment wedge and subducting turbidite package, both of which are influenced by basement topography. The trench wedge size and lithology, the lithology of the subducting section, and the basement topography all influence the rate of consolidation in the trench wedge, which we hypothesize is an important control over the presence and width of the protothrust zone. We conclude that protothrusts are fractures that form from shear surfaces in deformation band clusters as the trench fill sediment is consolidated. Strain localization occurs at sites with a high density of protothrusts, which become the probable locations of future frontal thrust propagation. The frontal thrust may propagate forward with a lower buildup of strain where it is adjacent to a wide protothrust zone than at areas with a narrow or no protothrust zone. This is reflected in the accretionary prism geometry, where wide protothrust zones occur adjacent to fault-propagation folds with shallow prism toe surface slopes.
Changing clinical characteristics of infants treated for hypoxic-ischaemic encephalopathy in England, Wales and Scotland: a population-based study using the National Neonatal Research Database
Authors: Hage Lory , Jeyakumaran Dusha , Dorling Jon , Ojha Shalini , Sharkey Don , Longford Nicholas , Modi Neena , Battersby Cheryl , Gale Chris 
Published: February 2021

BackgroundTherapeutic hypothermia is standard of care for babies with moderate/severe hypoxic-ischaemic encephalopathy and is increasingly used for mild encephalopathy.ObjectiveDescribe temporal trends in the clinical condition of babies diagnosed with hypoxic-ischaemic encephalopathy who received therapeutic hypothermia.DesignRetrospective cohort study using data held in the National Neonatal Research Database.SettingNational Health Service neonatal units in England, Wales and Scotland.PatientsInfants born from 1 January 2010 to 31 December 2017 with a recorded diagnosis of hypoxic-ischaemic encephalopathy who received therapeutic hypothermia for at least 3 days or died in this period.Main outcomesPrimary outcomes: recorded clinical characteristics including umbilical cord pH; Apgar score; newborn resuscitation; seizures and treatment on day 1. Secondary outcomes: recorded hypoxic-ischaemic encephalopathy grade.Results5201 babies with a diagnosis of hypoxic-ischaemic encephalopathy received therapeutic hypothermia or died; annual numbers increased over the study period. A decreasing proportion had clinical characteristics of severe hypoxia ischaemia or a diagnosis of moderate or severe hypoxic-ischaemic encephalopathy, trends were statistically significant and consistent across multiple clinical characteristics used as markers of severity.ConclusionsTreatment with therapeutic hypothermia for hypoxic-ischaemic encephalopathy has increased in England, Scotland and Wales. An increasing proportion of treated infants have a diagnosis of mild hypoxic-ischaemic encephalopathy or have less severe clinical markers of hypoxia. This highlights the importance of determining the role of hypothermia in mild hypoxic-ischaemic encephalopathy. Receipt of therapeutic hypothermia is unlikely to be a useful marker for assessing changes in the incidence of brain injury over time.
Patient education materials to implement choosing wisely recommendations for internal medicine at the emergency department
Authors: Laan Bart J , Huiszoon Willemijn B , Holleman Frits , Boermeester Marja A , Kaasjager Karin A H , Geerlings Suzanne E 
Published: February 2021

BackgroundChoosing Wisely aims to reduce low-value care to improve quality and lower costs. In the Netherlands, this campaign offers three recommendations for internal medicine applicable in emergency departments (EDs): (1) do not place an indwelling urinary catheter in non-critically ill patients who can void; (2) do not order plain abdominal radiographs in patients with acute abdominal pain; and (3) discuss whether treatment limitations are needed. This quality improvement project aims to increase the implementation of the recommendations by patient information leaflets.MethodsIn a prospective before–after study, we collected data every other week during baseline and intervention periods (both 7 months) in two university medical centres. The primary outcomes were the adherence rates to the recommendations.Results805 patients visited the EDs for internal medicine, of whom 391 (48.6%) were hospitalised. Only 153 (19%) patients received the information leaflet. We found no change in implementation rates of the recommendations after the introduction of the patient information leaflet. In the baseline period, 28 patients received a urinary catheter, of whom 5 (17.9%) had no appropriate indication, compared with 4 (25.0%) of 16 patients in the intervention period (p=0.572). Unnecessary abdominal X-ray occurred once in the baseline period and not in the intervention period. Treatment limitations were not reported in 13 (6.5%) of 200 hospitalised patients in the baseline period, and in 17 (8.9%) of 191 patients in the intervention period (p=0.373).ConclusionsPatient information leaflets did not increase the implementation of Choosing Wisely recommendations, which can be due to a high baseline rate and a poor dissemination of leaflets. Our ED seems not to be a practicable setting for dissemination of leaflets, since staff engagement was not possible due to high workload and shortage of qualified nursing staff in the Netherlands.
Improving antibiotic initiation and duration prescribing among nursing home physicians using an audit and feedback intervention: a theory-informed qualitative analysis
Authors: Laur Celia , Sribaskaran Thivja , Simeoni Michelle , Desveaux Laura , Daneman Nick , Mulhall Cara , Lam Jonathan , Ivers Noah Michael 
Published: February 2021

BackgroundIn nursing homes, 25%–75% of antibiotic days of treatment are inappropriate or unnecessary and are often continued for longer durations than necessary. In Ontario, physicians can receive a provincial audit and feedback report that provides individualised, confidential, data about their antibiotic prescribing. Objectives of this study were to explore antibiotic prescribing of nursing home physicians and the influence of the report.MethodsAll physicians who received a personalisedMyPractice: Long-Term Carereport from Ontario Health (Quality) (OH(Q)) in January 2019 (n=361) were eligible to participate in semistructured telephone interviews that were recorded then transcribed verbatim. Recruitment emails were sent from OH(Q) until saturation of ideas. Analysis was conducted by two team members inductively, then deductively using the theoretical domains framework, a comprehensive, theory-informed framework to classify determinants of specific behaviours.ResultsInterviews were conducted with n=18 physicians; 78% (n=14) were men, practising for an average of 27 years, with 18 years of experience working in nursing homes. Physicians worked in a median of 2 facilities (range 1–6), with 72% (n=13) in an urban setting. 56% (n=10) were medical directors for at least one home.Professional role and identityimpacted all aspects of antibiotic prescribing. Key roles included being an ‘Appropriate prescriber’, an ‘Educator’ and a ‘Change driver’. For antibiotic initiation, these roles interacted withKnowledge,Skills,Beliefs about consequence,Beliefs about capabilities,andSocial influenceto determine the resulting prescribing behaviour. When considering the impact of interacting with the report, participants’ perceived roles interacted withReinforcement,Social influence,andIntention. Environmental context and resourceswas an overarching domain.ConclusionThis theory-informed approach is being used to inform upcoming versions of existing audit and feedback initiatives. Appealing to the role that prescribers see themselves offers a unique opportunity to encourage desired changes, such as providing tools for physicians to be Educators and facilitating, particularly medical directors, to be Change drivers.
Adherence to guideline-recommended HbA1c testing frequency and better outcomes in patients with type 2 diabetes: a 5-year retrospective cohort study in Australian general practice
Authors: Imai Chisato , Li Ling , Hardie Rae-Anne , Georgiou Andrew 
Published: February 2021

BackgroundClinical practice guidelines emphasise the role of regular monitoring of glycated haemoglobin A1c (HbA1c) for patients with type 2 diabetes, with most recommending 6-monthly testing. Nonetheless, there are few in-depth studies evaluating the clinical impact of the recommended testing frequency for patients to underpin the significance of guideline adherence.ObjectiveThis study aimed to examine associations between patient outcomes and adherence to HbA1c testing frequencies recommended by Australian guidelines (6-monthly for patients with adequate glycaemic control and 3-monthly for patients with inadequate glycaemic control). The primary and secondary outcomes of interest were longitudinal changes in HbA1c values and development of ischaemic heart disease (IHD) and chronic kidney disease (CKD).MethodsThis 5-year retrospective cohort study (July 2013–June 2018) evaluated HbA1c testing frequency in a subset of patients with type 2 diabetes identified within data collected from approximately 250 Australian general practices. The study included patients who were aged ≥18 in 2013 and had a record of HbA1c testing in study practices during the study period. Each patient’s adherence rate was defined by the proportion of HbA1c tests performed within the testing intervals recommended by Australian guidelines. Based on the adherence rate, adherence level was categorised into low (≤33%), moderate (34%–66%) and high (>66%). Generalised additive mixed models were used to examine associations between adherence to the recommended HbA1c testing frequency and patient outcomes.ResultsIn the 6424 patients with diabetes, the overall median HbA1c testing frequency was 1.6 tests per year with an adherence rate of 50%. The estimated HbA1c levels among patients with low adherence gradually increased or remained inadequately controlled, while HbA1c values in patients with high adherence remained controlled or improved over time. The risk of developing CKD for patients with high adherence was significantly lower than for patients with low adherence (OR: 0.42, 95% CI 0.18 to 0.99). No association between IHD and adherence to the recommended HbA1c frequency was observed.ConclusionBetter adherence to guideline-recommended HbA1c testing frequency was associated with better glycaemic control and lower risk of CKD. These findings may provide valuable evidence to support the use of clinical guidelines for better patient outcomes in patients with type 2 diabetes.
Peripheral body temperature rhythm is associated with suicide risk in major depressive disorder: a case-control study
Authors: Ma Xin , Cao Jing , Zheng Hailin , Mei Xinchun , Wang Meijuan , Wang Haoran , Shuai Yu , Shen Yuan 
Published: February 2021

BackgroundPatients with major depressive disorder (MDD) may have an abnormal peripheral body temperature rhythm, but its relationship with suicidal risk and the response to treatment with antidepressants remain unknown.AimsThis study aimed to investigate the feature of peripheral body temperature in patients with MDD and its relationship with suicide risk before and after treatment with antidepressants.MethodsThis is a prospective case-control study. Patients diagnosed as MDD were enrolled into MDD group. Healthy subjects who matched in terms of gender, age and body mass index were enrolled into normal control (NC) group. The 24-hour peripheral body temperatures were monitored byTM’ Holterthe next day after assessment. Patients with MDD were re-assessed after a 2-week treatment with antidepressants. All temperature data were fitted into cosine curves byPython.ResultThere were 41 patients with MDD, and 21 NC participants enrolled and completed the baseline assessments before the treatment. Patients with MDD were further divided into subgroup of with suicide risk or without suicide risk. In patients with MDD, the mesor of peripheral body temperature rhythm was higher in both patients with (36.17 (0.30)) and without suicide risk (36.22 (0.27)) than the mesor in NC participants before treatment (35.84 (0.38), Z=11.82, p=0.003, Kruskal-Wallis test). The phase-delay of temperature before treatment was greater in patients with MDD with suicidal risk (4.71 (1.68)) in comparison with those without suicidal risk (3.05 (2.19)) and NC participants (3.19 (1.82), Z=9.68, p=0.008, Kruskal-Wallis test). Moreover, phase-delay of temperature was associated with suicide risk in patients with MDD before treatment (OR=1.046, 95% CI: 1.009 to 1.085, p=0.015, unadjusted; OR=1.080, 95% CI: 1.020 to 1.144, p=0.009, adjusted by age and sex).ConclusionPatients with MDD might have abnormal peripheral body temperature. The abnormal phase-delay of peripheral body temperature may indicate suicide risk in patients with MDD, depending on validation in large-scale cohorts.
123I-FP-CIT SPECT in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease: a new quantitative analysis of autopsy confirmed cases
Authors: Oliveira Francisco P M , Walker Zuzana , Walker Rodney W H , Attems Johannes , Castanheira Joana C , Silva Ângelo , Oliveira Carla , Vaz Sofia , Silva Mariana , Costa Durval C 
Published: February 2021

PurposeThe aim of this study was to re-evaluate the differentiation of patients with dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) and Parkinson’s disease (PD) using a quantitative analysis of123I-FP-CIT SPECT scans.MethodsThirty-six patients with in vivo123I-FP-CIT SPECT and neuropathological diagnoses were included. Based on neuropathological criteria, patients were further subclassified into nine AD, eight DLB, ten PD and nine with other diagnoses. An additional 16 healthy controls (HC) scanned with123I-FP-CIT SPECT were also included. All images were visually assessed as normal versus abnormal uptake by consensus of five nuclear medicine physicians. Bihemispheric mean was calculated for caudate binding potential (CBP), putamen binding potential (PBP) and putamen-to-caudate ratio (PCR).ResultsPatients with DLB had significantly lower CBP and PBP than patients with AD and significantly higher PCR than patients with PD. Qualitative visual analysis of the images gave an accuracy of 88% in the evaluation of the status of the nigrostriatal pathway considering all individuals, and 96% considering only the patients with PD, AD and DLB. Quantitative analyses provided a balanced accuracy of 94%, 94% and 100% in binary classifications DLB versus AD, DLB versus PD and PD versus AD, respectively, and an accuracy of 93% in the differentiation among patients with DLB, AD and PD simultaneously. No statistically significant differences were observed between the AD and HC.ConclusionsThis study demonstrates a very high diagnostic accuracy of the quantitative analysis of(123I-FP-CIT SPECT data to differentiate among patients with DLB, PD and AD.
Developing the ‘checking’ discipline
Authors: Yoong Wai , Sekar Hashviniya , Nauta Maud , Yoong Helienke , Lopes Tomas 
Published: February 2021

ABSTRACTWe explore how engagement with checklists and adoption of a strict ‘checking’ discipline help avoid unintentional individual, team and systemic errors. Paradoxically, this is equally important when performing repetitive mundane tasks as well as during times of high-stress workload. In this article, we aim to discuss the different types of checklists and explain how deviations from a ‘checking’ discipline can lead to never events such as wrong side or site surgery. Well-designed checklists function as mental notes and prompts in clinical situations where the combination of fatigue and stress can contribute to a decline in cognitive performance. Furthermore, the need for proactive discussion by all members of the team during the implementation of the surgical checklist also reinforces the concept of teamwork and contributes towards effective communication. Patient safety is often a product of good communication, teamwork and anticipation: a ‘checking’ mentality remains the lynchpin which links these factors.
Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study
Authors: Mahon Gillian M , Koppelman Gerard H , Vonk Judith M 
Published: February 2021

Background/objective
Limited research exists regarding the association between grandmaternal smoking during pregnancy and the risk for asthma and altered lung function in grandchildren. This study aimed to investigate this association in a three-generation design.

Methods
37 291 participants (25 747 adults and 11 544 children) were included from the Lifelines study, a prospective longitudinal three generation cohort study in The Netherlands. Spirometry was available in 69.5% and 61.1% of the included adults and children. Logistic and linear regression were used to analyse the association between grandmaternal smoking during pregnancy and (1) asthma, (2) early childhood asthma (ie, onset before 6 years) and (3) lung function level. Maternal and paternal grandmaternal smoking were studied separately and the analyses were stratified by adult/child and by gender. The analyses were adjusted for gender, current smoking, birth variables and socioeconomic status.

Results
In the adult population, maternal grandmaternal smoking during pregnancy was associated with a higher risk for asthma (OR (95% CI): 1.38 (1.06 to 1.79)), early childhood asthma (1.49 (95% CI 1.06 to 2.11)) and a lower FEV1/FVC% predicted (B (95% CI): −1.04 (−1.91 to −0.16) in men. These findings were not observed in a separate analysis of children that participated in this study. There was also no significant association between paternal grandmaternal smoking and asthma/lung function.

Conclusion
Maternal grandmaternal smoking during pregnancy is associated with higher asthma risk and lower lung function in male grandchildren and a reverse effect in male grandchildren of subsequent generations. Our study highlights the deep-rooted effects of tobacco smoking across generations.
Changes in cigarillo availability following implementation of a local flavoured tobacco sales restriction
Authors: Rogers Todd , Gammon Doris G , Coats Ellen M , Nonnemaker James M , Xu Xin 
Published: February 2021

IntroductionProvidence, Rhode Island (RI) was among the first US jurisdictions to enact a policy (effective 3 January 2013) restricting the retail sale of non-cigarette tobacco products with a characterising flavour other than the taste or aroma of tobacco, menthol, mint or wintergreen. We used scanner data to assess the impact of this sales restriction on retail availability of cigarillos, flavoured and otherwise, in Providence and a rest-of-state (ROS) comparison area.MethodsEvery unique cigarillo product—each indicated by a universal product code (UPC)—available for sale in RI from January 2012 to December 2016 was assigned to an exclusive flavour-name category (tobacco; explicit or concept flavour; or menthol/mint) based on characteristics in the scanner dataset and, as necessary, information from online websites. We calculated weekly unique cigarillo UPC counts and market share by flavour category and used difference-in-difference regression to assess prepolicy and postpolicy changes in counts and share in Providence relative to ROS.ResultsThe prepolicy to postpolicy decrease in the number of unique cigarillo products available in Providence was 28.64 (±5.83) UPCs greater than the comparable decrease in ROS (p<0.05). The prepolicy to postpolicy increase in the number of unique concept-named flavoured cigarillo products in Providence was 6.08 (±2.31) UPCs greater than the increase in ROS (p<0.05). The postpolicy market share of concept-named flavoured cigarillos was higher in Providence (27.32%, ±1.77) than ROS (12.67%, ±1.67) (p<0.05).ConclusionsAfter policy implementation, Providence consumers were exposed to fewer cigarillo UPCs but a greater variety and proportion of concept-named flavoured cigarillos in the retail marketplace.
Hybrid calculation of the MSSM Higgs boson masses using the complex THDM as EFT
Authors: Bahl Henning , Murphy Nick , Rzehak Heidi 
Published: February 2021

AbstractRecently, the Higgs boson masses in the Minimal supersymmetric standard model (MSSM) and their mixing have been calculated using the complex two-Higgs-doublet model (cTHDM) as an effective field theory (EFT) of the MSSM. Here, we discuss the implementation of this calculation, which we improve in several aspects, into the hybrid framework of by combing the cTHDM-EFT calculation with the existing fixed-order calculation. This combination allows accurate predictions also in the intermediate regime where some SUSY particles are relatively light, some relatively heavy and some in between. Moreover, the implementation provides precise predictions for the Higgs decay rates and production cross-sections.