bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated gamma-glutamyl transferase has a non-linear association with incident non-alcoholic fatty liver disease in the non-obese Chinese population: a secondary retrospective study
Authors: Wu Liling , Zhang Man , Hu Haofei , Wan Qijun 
Published: August 2021

Abstract
Background

Effective and applicable predictors of non-alcoholic fatty liver disease (NAFLD) are needed for the non-obese Chinese population. We investigated whether serum gamma-glutamyl transferase (GGT) was associated with incident NAFLD in the non-obese Chinese population.
Methods

This was a retrospective cohort study that enrolled a total of 33153 initially NAFLD-free individuals who underwent a health examination in Wenzhou Medical Center of Wenzhou People’s Hospital from January 2010 to December 2014. We determined the relationship between GGT at enrollment and incident NAFLD during follow-up in 11906 persons. The relationship between GGT levels and incident NAFLD was analyzed using Cox regression and generalized additive models after adjustment for demographic and clinical variables. In addition, we also performed a subgroup analysis, which was explored by Cox proportional hazard models. It was stated that the data had been downloaded from the DATADRYAD website.
Result

Multivariable Cox regression models were used to estimate the hazard ratio (HR) for GGT with incident NAFLD after adjusted demographic and clinical variables. (HR, 1.010; 95% CI, 1.007–1.012; P < 0.001). The incident NAFLD in the highest quartile of GGT levels was 3.653 times as high (95% confidence interval, 2.915 to 4.579) as that in the lowest quartile. A non-linear relationship was firstly detected between GGT and incidence of NAFLD, which had an inflection point of GGT was 26U/L. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 1.104(1.089–1.120)and 1.001༈0.999–1.004༉, respectively. In subgroup analyses, the hazard ratio for incident NAFLD remained consistent across subgroups.
Conclusion

In conclusion, the GGT level in the non-obese Chinese population was statistically significantly associated with incident NAFLD. The relationship between GGT level and incident NAFLD is non-linear. When GGT level is less than 26 U/L, GGT was strong positively with incident NAFLD.
Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors
Authors: An Lei , Chen Shuqing , Wu Guangyao , Liu Chang , Wang Zhenxing , Wang Chunli , Shi Zeyuan , Niu Chenguang , Li Xiaodong , Tang Wenxue , Xu Hongen , Wang Yueqiang 
Published: September 2021

Abstract
Background: Tyrosine kinase inhibitors (TKIs) therapy is a standard treatment for patients with advanced non-small-cell lung carcinoma (NSCLC) when activating epidermal growth factor receptor (EGFR) mutations are detected. However, except for the well-studied EGFR mutations, most EGFR mutations lack treatment regimens. Methods: We constructed two EGFR variant libraries containing substitutions, deletions, or insertions using the saturation mutagenesis method. All the variants were located in the EGFR mutation hotspot (exons 18–21). The sensitivity of these variants to afatinib, erlotinib, gefitinib, icotinib, and osimertinib was systematically studied by determining their enrichment in massively parallel cytotoxicity assays using an endogenous EGFR-depleted cell line, PC9.Results: A total of 3,914 and 70,475 variants were detected in the constructed EGFR Substitution-Deletion (Sub-Del) and exon 20 Insertion (Ins) libraries, accounting for 99.3% and 55.8% of the designed variants, respectively. Of the 3,914 Sub-Del variants, 813 were highly enriched in the reversible TKI (erlotinib, gefitinib, icotinib) cytotoxicity assays and 51 were enriched in the irreversible TKI (afatinib, osimertinib) cytotoxicity assays. For the 70,475 Ins variants, insertions at amino acid positions 770–774 were highly enriched in all the five TKI cytotoxicity assays. Moreover, the top 5% of the enriched insertion variants included a glycine or serine insertion at high frequency. Conclusions: We present a comprehensive reference for the sensitivity of EGFR variants to five commonly used TKIs. The approach used here should be applicable to other genes and targeted drugs.
Fired Heater Simulation, Modelling and Optimization
Authors: brakat Taj Alasfia M , Hassan Mahmoud Adam 
Published: September 2021

Abstract
In this study a dynamic model Simulation was carried out using ASPEN HYSY for industrial refinery fired heater, PID controller was applied to control the flue gas exit temperature. the simulation shows perfect agreement with the datasheet of the furnace. It was found that Increasing the number of the tube rows in convection bank from 2 to 3 allows us to recover approximately 5% of the overall efficiency, hence the duty furnace has increased from 65.9MW to 68.1MW and the fuel flow in like manner has increased from 5597kg/h to 5807kg/h moreover Adding more rows has a reverse return as we start to notice increase on the flue gas temperature. Furthermore, sensitivity analysis was conducted with HYSYS to determine one of the most important parameters that affect the performance of the heater based on the data generated from the simulation. MATLAB code was generated for efficiency calculation and for parameter manipulation, the code was designed to be flexible as possible, user will just need to replace the nominal fuel and air characteristics. for gaining optimum furnace operation the heat transfer inside the furnace was studied, and the results were compared with previous research involving furnace analysis to validate models, the heat transfer coefficient is determined by analysis of conductive heat transfer through the boundary layer. well-stirred model was used for mathematical model calculations and for optimization of furnace operation, the models were validated with ASPEN Exchanger Design and Rating(EDR) alongside ASPEN HYSYS
Comparative Transcriptome Analysis of Storage Root Reveals Regulatory Mechanisms of Lignin Biosynthesis During Root Development in Two Sweetpotato Cultivars
Authors: Hou Fuyun , Qin Zhen , Du Taifeng , Zhou Yuanyuan , Li Aixian , Dong Shunxu , Ma Daifu , Zhang Liming , Li Zongyun , Wang Qingmei 
Published: September 2021

Abstract
BackgroundSweetpotato(Ipomoea batatas (L.) Lam.) is one of the most important crops with high storage roots yield. Lignin affects the storage root formation. However, the molecular mechanisms of lignin biosynthesis in storage roots development have been lacking.ResultsTo reveal the molecular mechanism of lignin biosynthesis and identify new homologous genes in lignin biosynthesis during storage root development, the storage root (SR) at three different stages (D1, D2 and D3) in the two cultivars (Jishu25 and Jishu29) was investigated with full-length and second-generation transcriptome. A total of 52,137 transcripts and 21,148 unigenes were obtained after corrected with Hiseq2500 sequencing. Through the comparative analysis, 9577 unigenes were found to be differently expressed in the different stage in two cultivars. Among of them, 91 unigenes enriched in the phenylpropanoid biosynthesis, and 201 unigenes in hormone signal transduction pathway with KEGG analysis. Weighted gene co-expression network analysis of differentially expressed unigenes showed that lignin biosynthesis genes might be co-expressed with transcription factors such as AP2/ERF and MYB at the transcription level, and regulated by phytohormones auxin and GA3.Conclusions﻿Taken together, our findings will throw light on molecular regulatory mechanism of lignin biosynthesis involved in storage root development.
Induction of Internal Circadian Desynchrony by Misaligning Zeitgebers
Authors: Heyde Isabel , Oster Henrik 
Published: September 2021

Abstract
24-hour rhythms in physiology and behaviour are orchestrated by an endogenous circadian clock system. In mammals, these clocks are hierarchically organized with a master pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN). External time signal – so-called zeitgebers – align internal with geophysical time. During shift work, zeitgeber input conflicting with internal time induces circadian desynchrony which, in turn, promotes metabolic and psychiatric disorders. However, little is known about how internal desynchrony is expressed at the molecular level under chronodisruptive environmental conditions. We here investigated the effects of zeitgeber misalignment on circadian molecular organisation by combining 28-hour light-dark (LD-28) cycles with either 24-hour (FF-24) or 28-hour feeding-fasting (FF-28) regimes in mice. We found that FF cycles showed strong effects on peripheral clocks, while having little effect on centrally coordinated activity rhythms. Systemic, i.e., across-tissue internal circadian desynchrony was induced within four days in LD-28/FF-24, while phase coherence between tissue clocks was largely maintained under LD-28/FF-28 conditions. In contrast, temporal coordination of clock gene activity across tissues was reduced under LD-28/FF-28 conditions compared to LD-28/FF-24. These results indicate that timed food intake may improve internal synchrony under disruptive zeitgeber conditions but may, at the same time, weaken clock function at the tissue level.
Structural, Magnetic Properties and Hyperthermia Efficiency of MF/CuAl2O4 Multiferroic Nanocomposite
Authors: Roumaih Roumaih , Abd-elrahem Ismail , Hussein Shaban I. 
Published: September 2021

Abstract
The multiferroic MF/CuAl2O4 (MF= CoFe2O4, NiFe2O4, MgFe2O4, and ZnFe2O4) was prepared using two stages of the sol-gel method. X-ray Diffraction (XRD), the Fourier transforms infrared absorption (FT-IR) and High-resolution Transmission Electron Microscope (HR-TEM) were used to examine the structure of all samples. From the XRD patterns, two standards of cubic spinels structure (CuAl2O4 + MF) were observed. The analysis of FTIR spectra confirmed the formation of the chemical and molecular structure changes in the MF/CuAl2O4. HR-TEM images showed a uniform particle distribution with a nanoscale of all samples. The magnetic properties were studied from the hysteresis loops using a vibrating sample magnetometer (VSM) and the magnetization M (T) by the Faraday balance method. All samples exhibited typical ferrimagnetic behavior, except for ZnF/CuAl recorded superparamagnetic. Curie temperature (TC) for all nanocomposites obtained from M(T) protocols, which is lower than the standard value of MF nanoferrites. The heating efficiency of all samples was investigated by measuring the Specific Absorption Rate (SAR) parameter. The SAR of NiF/CuAl showed a maximum value as well as saturation magnetization (Ms) and lowest coercivity (Hc) value.
Viridibacillus Soli sp.nov., Isolated from Forest Soil in Ailaoshan National Nature ReserveViridibacillus Soli sp.nov., Isolated from Forest soil in Ailaoshan National Nature Reserve
Authors: Xu Yan , Zhao Jiang-Yuan , Geng Yu , Yuan Hui-Ren , Li Le-Le , Wen Meng-Liang , Li Ming-Gang , Tang Shu-Kun 
Published: September 2021

Abstract
A Gram-staining positive, rod-shaped, and subterminal endospore-forming bacterium, designated strain YIM B01967T, was isolated from a forest soil sample collected in Ailaoshan National Nature Reserve, Yuxi City, Xinpin county, Yunnan province, China. Strain YIM B01967T showed the highest 16S rRNA gene sequence similarity with Viridibacillus arvi (99.1%) and Viridibacillus arenosi (98.9%). Based on the phylogenetic and 16S rRNA gene sequence results, strain YIM B01967T was affiliated to the genus Viridibacillus. The growth of YIM B01967T was observed at 15–35°C (optimum, 28°C), pH 7.0–9.0 (optimum, pH 7.5) and in the presence of 0–2% (w/v) NaCl (optimum in 2% NaCl). The cell-wall sugars include ribose, glucose, arabinose, galactose, and mannose. The quinone system consisted of the major compound MK-8 and moderate amounts of MK-7. The major fatty acids (> 10%) were iso-C15:0, anteiso-C15:0, C16:1 ω10c. The major polar lipids profile included DPG, PME. The cell wall peptidoglycan was most likely of the type A4α with an L-Lys–D-Asp interpeptide bridge. The genomic DNA G + C content of strain YIM B01967T was 36.3 mol%. The ANI and dDDH values between strain YIM B01967T and the two reference strains Viridibacillus arvi DSM 16317T and Viridibacillus arenosi DSM 16319T are 61.0% and 32.1%, 60.0% and 33.1% based on the draft genome sequence. The results support the conclusion that strain YIM B01967T represents a novel species of the genus Viridibacillus, the for which the name Viridibacillus soli sp. Nov., is proposed.The type strain is YIM B01967T (= KCTC 43249T = CGMCC 1.18436T).
Efficient Electromagnetic Transducers For Spin-Wave Devices
Authors: Connelly David , Csaba Gyorgy , Aquino Hadrian Renaldo O. , Bernstein Gary H. , Orlov Alexei , Porod Wolfgang , Chisum Jonathan 
Published: September 2021

Abstract
This paper presents a system-level efficiency analysis, a rapid design methodology, and a numerical demonstration of efficient sub-micron, spin-wave transducers in a microwave system. Applications such as Boolean spintronics, analog spin-wave-computing, and magnetic microwave circuits are expected to benefit from this analysis and design approach. These applications have the potential to provide a low-power, magnetic paradigm alternative to modern electronic systems, but they have been stymied by a limited understanding of the microwave, system-level design for spin-wave circuits. This paper proposes an end-to-end microwave/spin-wave system model that permits the use of classical microwave network analysis and matching theory towards analyzing and designing efficient transduction systems. This paper further compares magnetostatic-wave transducer theory to electromagnetic simulations and finds close agreement, indicating that the theory, despite simplifying assumptions, is useful for rapid yet accurate transducer design. It further suggests that the theory, when modified to include the exchange interaction, will also be useful to rapidly and accurately design transducers launching magnons at exchange wavelengths. Comparisons are made between microstrip and co-planar waveguide lines, which are expedient, narrowband, and low-efficiency transducers, and grating and meander lines that are capable of high-efficiency and wideband performance. The paper concludes that efficient microwave-to-spin-wave transducers are possible and presents a meander transducer design on YIG capable of launching λ=500nm spin waves with an efficiency of -4.45 dB and a 3 dB-bandwidth of 134 MHz.
Identification and Mitigation of High-Risk Pregnancy with the Community Maternal Danger Score Mobile Application in Gboko, Nigeria
Authors: Bola Rajan , Ujoh Fanan , Lett Ronald 
Published: August 2021

Abstract
Introduction Nigeria constitutes 1% of the world’s population yet accounts for 10% of global maternal mortality. Risk analyses within rural regions of Nigeria are not routinely conducted, yet could help inform access to skilled birth care. The objectives of this study were to assess the proportion of women at risk for mortality or morbidity in Benue State, Nigeria by analysing data collected during routine antenatal visits and through the Community Maternal Danger Score (CMDS), a validated risk-analysis tool. Methods Two cohorts, comprised of pregnant women presenting to primary healthcare centres within Gboko, Benue State between 2015-2017 and 2020-2021, were included in this study. The 2015-2017 cohort had their risk assessed retrospectively through analysis of routinely collected data. Identification of risk was based on their age, parity, and disease status (HIV and diabetes). The 2020-2021 cohort had their risk assessed prospectively using the CMDS. Results Routinely collected data from 2015-2017 demonstrated that up to 14.9% of women in Gboko were at risk for mortality or morbidity. The CMDS reported that up to 21.5% of women were at a similar level of risk; a significant difference of 6.6% (p=0.006). The CMDS was more efficient in obtaining and assessing this data, and the identification was available in real-time for midwives and pregnant women. Conclusion Routine data collected in Gboko identifies a high proportion of pregnant women at risk for mortality or morbidity. The CMDS is an evidence-based risk analysis tool that expands on this assessment by also estimating individual and community-level risk, which allows for more efficient mitigation and prevention strategies of maternal mortality.
Multiband Slotted Planar Inverted-F Antenna using Reactive Impedence Surface for Wireless Applicatios
Authors: Jadhav Tejaswi Mahaling J 
Published: August 2021

Abstract
This research work presents a low profile slotted planar invertedF antenna (PIFA) on a reactive impedance surface (RIS) for multiband. The quad-band frequency antenna for 2.4 GHz (WLAN), 4.2 GHz (C-band satellite downlink), 7.1 GHz (C-band satellite uplink), and 9 GHz (X-band )for wireless applications. The structure of the proposed PIFA has a compacted patch size of 23.33 mm × 2.66 mm × 1 mm placed on a dielectric substrate flame retardant 4(FR4) material, along with tangent loss = 0.02. The proposed antenna used two dielectric substrates whose heights are h1 = 1.59 mm and h2 = 1 mm . The rectangular slot is added in a radiating patch of the PIFA for multiband operations. The proposed antenna improves the parameters such as reduction scale, efficiency, narrow bandwidth, and gain enhancement. The slotted PIFA shows a quad-band with an S11 <-10 dB bandwidth of approximately 15.83% (2.24-2.62 GHz), 11.19% (3.93-4.4GHz), 12.67% (6.90-7.80GHz) and 10.55% (8.29-9.24GHz) under measurement. The proposed antenna design is excited by 50Ω microstrip line feed. The antenna exhibits radiation pattern, gain, and impedance matching across their operating bandwidths to demonstrate the benefits of multiple PIFA.
Optical Theodolite Based Rationality Check of Measurement Data From Pulse Radar
Authors: Hu Shaolin , Jiang Wenqiaqng , Liang Jiahui , Li Jian 
Published: September 2021

Abstract
Theodolite and radar are important measurement and control devices in aviation, aerospace and other fields. In order to make sure the tracking measurement and navigation control of aircraft and spacecraft safely, this paper creatively proposes a novel method to check the rationality of the three-dimensional measurement data (distance, azimuth and pitch angle) of the pulse radar by using the two-dimensional measurement data (azimuth and pitch angle) of the optical theodolite. Specifically, three different rationality checking functions are constructed for the three different cases of unreliable ranging channel, unreliable angle measuring channel and unreliable ranging and angle measuring channels, and are used for the rationality checking of radar data in the above three cases respectively. Simulation results show that the correct rate is more than 95% as long as the data measured by optical theodolite are reliable.
Corona - eine Krise für die Kooperation?
Authors: Langner Anke , Milker Clemens 
Published: September 2021

Der Artikel greift vor dem Hintergrund der Theorieperspektive der Synthetischen Humanwissenschaften auf, wie sich Kooperationsbeziehungen von Schüler*innen und Lehrpersonen in ihrer Intensität wie Funktionalität durch die pandemiebedingt plötzlich und signifikant auftretenden Änderungen des Alltags der Institution Schule verändern. Dies wird hinsichtlich der Auswirkungen auf individuelle Entwicklung und Entwicklungspotentiale von Schüler*innen gespiegelt, um daran anknüpfend Ableitungen für Bildungsprozesse zu ziehen. Einzelne Ausschnitte aus explorativ geführten Interviews erweitern den theoretischen Bezugsrahmen durch Aussagen von Praktiker*innen hinsichtlich einer schulischen und professionstheoretischen Perspektive.

Abstract
The article discuses theoretically how cooperation among students and teachers changed in its intensity and functionality for learning during the significant changes of the institution school due to the Corona-pandemic restrictions. Those changes are to be analysed in their influence on individual development and potentials. Selected explorative interviews with teachers and parents about their perception on the crisis and its caused changes may add a practical perspective from school to the pedagogical theory.
Validation and optimization of a new instrument for measuring the performances of ultrafiltration membranes
Authors: Guo Linyuan , Rong Yan , Dai Qiang , Li Jingmiao , Feng Shichun , Jin Dong 
Published: September 2021

Abstract
In this study, we introduce the current situation of the membrane inspection industry. We have developed a new integrated rapid membrane inspection machine (MIM) to test the performances of nanofiltration or ultrafiltration membranes by measuring the silt density index (SDI) value (i.e., the key performance indicator) of the water filtered. This study optimizes many key conditions include temperature, pH value and pressures, then establishes a new SDI detection method of ultrafiltration membranes by using MIM. We set the temperature of the test liquid to 25 °C, pH in the range of 7–8, and pressure to approximately 0.10 MPa. The results reflect that MIM can be used to effectively determine the SDI of ultrafiltration membranes using the new method and the results of the method validation are satisfactory.
The operation of the Cardinal Stefan Wyszyński University (Warsaw) archive based on its reports from 2003 to 2015
Authors: Poletyło Roman 
Published: August 2021

The 15th anniversary of the establishment of the Cardinal Stefan Wyszyński University (UKSW) archive is a good moment to reflect on its operation. Its annual reports enable us to recognize the scale and quality of the archive’s operation. Reports prepared between 2003 and 2015 for various purposes and authorities show how the archive has fulfilled its basic duties.
The quality of UKSW’s archive is monitored by the State Archive in Warsaw.As ainter-faculty unit of UKSW, the archive also comes under the authority of one of the University’s deputy vice-chancellors.The archive mainly reports to these principal bodies on an annual basis.The archive holds the records of the Warsaw Theological Academy which was later transformed into UKSW.