bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaya Hidup Berhubungan dengan Hipertensi
Authors: Suprayitno Emdat , Sumarni Sri , Islami Isqi Lailatul 
Published: October 2021

Abstract
Hypertension is a major problem as a risk factor for death in cardiovascular disease caused by genetic and lifestyle factors. The purpose of this study was to analyze the relationship between hypertension and lifestyle in Poja Village, Gapura District. This study used a cross sectional analytic design. The population in this study were 73 people. The sampling technique was simple random sampling and data analysis used the Chi Square test, the data collection technique used online questionnaire forms (google forms). Chi square test results obtained P value = 0.001 <a (0.05), which means that there is a relationship between hypertension and lifestyle in Poja Village, Gapura District. Therefore it is important to always adopt a good and healthy lifestyle to prevent hypertension
Keywords: Hypertension, lifestyle, the incidence of hypertension
NILAI PENDIDIKAN KARAKTER CERITA "ARIA TADUNG WANI PEWARIS PUSAKA SAKTI DAN DUA BADANGSANAK DAN HANTU NI BAYUR" KARYA ALIANSYAH JUMBAWUYA (The Character Education Value of "The Story of Tadung Wani Pewaris Pusaka Sakti, Dua Badangsanak and Hantu Ni Bayur" by Aliansyah Jumbawuya
Authors: Jahdiah NFN 
Published: October 2021

Abstrak:Cerita rakyat merupakan salah satu dari sastra lisan yang ada di Nusantara. Cerita rakyat sperti karya sastra lainnya. Penelitian ini bertujuan mendeskripsikan nilai-nilai pendidikan karakter yang terdapat dalam cerita rakyat Aria Tadung Wani Pewaris Pusaka Sakti dan Dua Badangsanak dan Hantu Ni Bayur. Masalah yang diangkat dalam penelitian ini adalah nilai-nilai pendidikan karakter apa yang terdapat dalam dua cerita tersebut. Metode yang digunakan dalam penelitian ini adalah menggunakan metode deskripsif dengan pendekatan kualitatif. Hasil penelitian menunjukan bahwa dalam cerita Aria Tadung Wani Pewaris Pusaka Sakti mempunyai nilai pendidikan karakter jujur, kerja keras, bersahabat, cinta damai, peduli sosial, , dan tanggung jawab. Nilai pendidikan yang terdapat dalam cerita Dua Badangsanak dan Ni Bayur berisi nilai pendidikan kerja keras, cinta damai, kreatif, demokrasi, dan rasa ingin tahu.AbstractFolklore is one of oral literature that exists in Indonesian archipelago. Like any other literature, folklore has values in our life, including the value of character education. This study aims to describe the value of character education in the folklore entitled Aria Tadung Wani Pewaris Pusaka Sakti dan Dua Badangsanak dan Hantu Ni Bayur. The problem which is raised in this study is what kind of the value of character education in both stories. This study uses descriptive method by using qualitative approach. The result shows that the folklore entitled Aria Tadung Wani Pewaris Pusaka Sakti has the value of character education of Honest, hardworking, friendly, peace loving, socially responsible and responsibility The values of character education in the folklore entitled Dua Badangsanak dan Hantu Ni Bayur are hard worker, loving peace, creative, social care, and curiosity.
Fałszywe nuty w piosenkach dziecięcych. O oczywistych i mniej oczywistych funkcjach piosenek dla dzieci we wczesnej edukacji
Authors: Pilecka Małgorzata 
Published: October 2021

Celem artykułu jest problematyzacja pedagogicznej kategorii piosenki dziecięcej oraz krytyczna charakterystyka funkcji, które spełnia (?) ona we wczesnej edukacji. Zostały tu przywołane różne sposoby ujmowania piosenki dziecięcej jako specyficznego tekstu kultury, a także zarysowano pokrótce miejsce piosenki dziecięcej w zorganizowanych formach wczesnej edukacji muzycznej. Z literatury przedmiotu oraz z praktyki własnej autorki wynika, że postulowana wartość (edukacyjna, artystyczna, wychowawcza) piosenki dziecięcej zanika w obliczu chaosu pojęciowego i organizacyjnego związanego z wymogiem prowadzenia tzw. edukacji zintegrowanej.
Evaluation of locally produced caecal coccidiosis vaccine in male Faobro breeders
Authors: Kasab Atheer K. , Khadhim Furkan S. 
Published: October 2021

Mature oocysts of Eimeria tenella have been attenuated by Gemma irradiation 200 and 300 gray. Excystation of occysts were examined. The immunoeffeciency of irradiated oocysts were studied in broiler that vaccinated with 5x10° attenuated oocyst per chick. A total of 1500 day-old Faobro chicks were divided into 6 groups and were treated as follows: Group C: un vaccinated control. Group WF: Given the vaccine in the feed.
Group DW: Given the vaccine in drinking water. Group CI: Given the vaccine in the crop. Group SP: Given the as a coarse spray. Group CIT: Given the attenuated vaccine in the crop (300 Gray) at day old and (200 Gray) at 14 days of age.
The groups were challenged at 40 days of age with 5x104 viable oocysts of Eimeria tenella per chick. The clinical sings were recorded, the body weight was taken weekly, lesion score, packed cell volume, litter moisture, oocyst count in the litter and oocyst count in the caecal content were determined one week after vaccination, one day before challenge and one week after challenge. The protection ratio and mortality rate were estimated. Results revealed that attenuated oocysts have lost its pathogenicity, no clear clinical sings after vaccination has been recorded, but some chicks of all vaccinated groups show a slight bloody excretion. Some groups given significant increase in body weight in
comparison with the control before and after challenge. The protection ratio was 93.5% for WF, 88.8% for DW, 98.3% for CI, 93.1% for SP and 82.2% for
The mortality rate was significantly higher in the control than the CIT group. vaccinated groups, the CIT group recorded mortality that was 2.9% the CI and SP recorded 0% and the C group recorded 10%
It was concluded that vaccination with all the methods used in this experiment provided good protection against challenge. The spray method was recommended best, then the drinking water and then with feed method.
Effect of Garlic in ration on immune response of broiler chicken
Authors: Shalash Ali A.H. , Al-Ibadi Israa N. A. 
Published: October 2021

This study was conducted to investigate the effect of two levels of garlic supplementation to broiler ration on immune response to Newcastle and Gumboro vaccines.
A total of 120 chick of broiler breeder males faobro strain were used at one day old. The birds at seven days old were divided into three groups. Each group was consisted of fourty birds. The first group (T1) was treated with garlic at 1% ratio. The second group (T2) was treated with garlic at 2% ratio , while control group (C) was not given garlic with ration.
The birds were immunized after decline of Maternal Antibodies of Newcastle and Gumboro until (34) days old. The first vaccine occurred at 35 day old with combined vaccine of Newcastle lasota -C30 strain and Gumoro Lukert strain, second vaccine was done after ten days from the first vaccine.
The titer of haemagglutination inhibition antibodies of Newcastle vaccine, titer of Gumboro precipitating antibodies and the titer of antibodies in ELISA test to these vaccine were measured after ten days of each vaccine, and the results were as follows: -The titer of haemagglutinating inhibiting antibodies of Newcastle vaccine was increased significantly in Tl and T2 groups (P < 0.05) compared with control group. -The titer of Gumboro precipitating antibodies was increased significantly in Ti and T2 groups (P < 0.05) compared with control group after second vaccine only. -ELISA test results indicated a significant increase in titer of antibodies of Newcastle and Gumboro vaccines (P <0.05) compared with control group.
Ἀναγωγή in Ancient Greek Exegetical Literature
Authors: Тимофеев Борис 
Published: October 2021

Термин ἀναγωγή довольно часто употребляется в древних памятниках христианской богословской и экзегетической литературы в разных значениях, что во многом затрудняет понимание этого слова в каждом отдельном случае. В рамках экзегетической процедуры ἀναγωγή употребляется в метафорическом значении и обозначает переносный смысл, а иногда и переносное понимание текста, когда речь идёт о метафорическом содержании фигур речи или о присутствии мистического аллегорического смысла. Современная отечественная библейская наука склонна видеть в ἀναγωγή определённый духовный метод/смысл интерпретации Священного Писания (чаще всего имеется в виду эсхатологическое толкование). Когда эта модель переносится на почву древней экзегетической литературы, то неизбежно возникает противоречие между современным определением и своеобразием языка древних авторов. В рамках данной статьи предпринимается попытка рассмотреть основные значения ἀναγωγή в древних экзегетических памятниках.
Ἀναγωγή is quite often used in ancient monuments of Christian theological and exegetical literature in different meanings, which greatly complicates the understanding of this word in each individual case. Within the framework of the exegetical procedure, anagoge is used in a metaphorical meaning and denotes a figurative meaning, and sometimes at the same time a figurative understanding of the text, when it comes to the metaphorical content of figures of speech, or the presence of a mystical allegorical meaning. Modern Russian biblical science tends to see in ἀναγωγή a certain spiritual method/meaning of the interpretation of the Holy Scriptures (most often it means the eschatological interpretation). When this model is transferred to the soil of ancient exegetical literature, then a contradiction arises between the modern definition and the originality of the language of ancient authors. Within the framework of this article, an attempt is made to consider the main meanings of ἀναγωγή in ancient exegetical monuments.
RELATIONSHIP BETWEEN SCREEN TIME AMONG CHILDREN WITH NUTRITIONAL STATUS AND THEIR DEVELOPMENT
Authors: Maqfiro Siska Nawang Ayunda , Fajrin Irmasanti , Suaib Nurkila 
Published: October 2021

Background: The growth and development of children are two events that are different in nature but are related to one another. It is possible for people in downtown areas to experience easy internet access, so that everything cannot be separated from digital media. Especially during the COVID-19 pandemic like today, where children have to stay at home more, besides that learning is also done from home, so the screen time has increased. The goals of the research is to analyze the relationship between screen time among children with nutritional status and their development.Methods: The research design used cross sectional analysis. The population is all children aged 3-5 years in Kalumpang Village in November 2020 as many as 497 children, the number of samples is 84 children using purposive sampling technique.Results: Based on the spearman-rank statistical test, it is known that p-value = 0.002 (p-value α), which with the correlation coefficient (r) = 0.330 that the relationship between Screen time with nutritional status is in the low category and has a positive relationship direction, namely the higher the screen time, the higher the nutritional status. Meanwhile, based on the spearman-rank statistical test, it is known that p-value = 0.001 (p-value α), with the correlation coefficient (r) = 0.371 that the relationship between Screen time with development is in the low category and has a positive relationship direction, namely the higher the screen time, the development will deviate from age.Conclusion: There is a relationship between screen time and nutritional status and there is a relationship between screen time and children development. So it is very important to improve parental control behavior towards the use of electronic devices in children aged 3-5 years old.
Effect of Calcium Level in Feed on Blood Profile of Broiler Chicken
Authors: Salu Modesta , Lisnahan Charles Venirius , Nahak Oktovianus R. 
Published: October 2021

This study aims to determine the effect of calcium supplementation in feed on the blood profile of broilers chickens. This research was conducted in a broiler chicken coop, owned by breeders in Sasi Village, Kefamenanu City District, North Central East District. This research was conducted from July to August 2020. This study used 96 broilers. The method used in this was a completely randomized design consisting of 4 replications and 4 treatments. The treatments given were T0 (control diet), T1 (calcium supplementation 1,00 %), T2 (calcium supplementation 1,50 %), T3 (calcium supplementation 2,00 %). The variables observed in this study were the content of erythrocytes, hemoglobin, and blood leucocytes. The data obtained were analyzed using analysis of variance. Analysis of variance showed that the treatment had no significant effect on erythrocytes, hemoglobin, and leucocytes of broiler chickens. It was concluded that the addition of calcium in feed at different levels did not increase the content of erythrocytes, hemoglobin, and leucocytes of broiler chickens aged 6 weeks.
PENGARUH METODE PENGERINGAN YANG BERBEDA TERHADAP KOMPOSISI KIMIA, VITAMIN C DAN AKTIVITAS ANTIOKSIDAN ANGGUR LAUT Caulerpa racemosa
Authors: Indayani Mimin Kaidah , Asnani Asnani , Suwarjoyowirayatno Suwarjoyowirayatno 
Published: October 2021

ABSTRACT Caulerpa racemosa is one of the potential biodiversity of Indonesian waters that has functional compounds including antioxidants and vitamin C. The aim of this study was to determine the effect of the drying method on chemical composition, phytochemical content and antioxidant activity and vitamin C. racemosa which was dried by sun-drying method and drying at 40°C and 50°C. The results obtained showed that the lowest water content was found in C1 treatment,15,85%, the lowest fat content of 0,39% in C3 treatment, the lowest ash content in C1 treatment was 38,27%, and the highest carbohydrate was in C1 treatment is 19,66%. Phytochemical testing showed the presence of alkaloids, flavonoids, steroids, and saponins and there is no hydroquinone compound, while the highest antioxidant and vitamin C activity were found in C2, 652,41 ppm and 13,1 mg / g, respectively.KeyWords: Caulerpa racemosa, drying, phytochemicals, vitamin C, antioxidants ABSTRAKCaulerpa racemosa merupakan salah satu potensi keanekaragaman hayati perairan Indonesia yang memiliki senyawa fungsional diantaranya antioksidan dan vitamin C. Tujuan penelitian ini adalah untuk mengetahui pengaruh metode pengeringan terhadap komposisi kimia, kandungan fitokimia dan aktivitas antioksidan serta vitamin C. racemosa yang dikeringkan dengan metode pengeringan sinar matahari serta pengeringan pada suhu 40°C dan suhu 50°C. Hasil yang diperoleh menunjukan bahwa nilai kadar air terendah terdapat pada perlakuan C1 yaitu 15,85%, kadar lemak terendah yaitu 0,39% pada perlakuan C3, kadar abu yang terendah ada pada perlakuan C1 yaitu 38,27%, dan karbohidrat tertinggi terdapat pada perlakuan C1 yaitu sebesar 19,66%. Pengujian fitokimia menunjukan adanya kandungan alkaloid, flavonoid, steroid dan saponin dan tidak terdapat senyawa hidroquinon, sementara pada pengujian aktivitas antioksidan dan vitamin C tertinggi terdapat pada C2 masing-masing 652,41 ppm dan 13,1 mg/g.Kata Kunci: Caulerpa racemosa, pengeringan, fitokimia, vitamin C, antioksidan
Patients Unmet Needs in Chronic Rhinosinusitis With Nasal Polyps Care: A Patient Advisory Board Statement of EUFOREA
Authors: Claeys N. , Teeling M. T. , Legrand P. , Poppe M. , Verschueren P. , De Prins L. , Cools L. , Cypers L. , Fokkens W. J. , Hopkins C. , Hellings P. W. 
Published: October 2021

Background: European patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have had only limited occasions to unite to have their voices heard, hence missing the opportunity to contribute to the improvement of CRSwNP care.Aims: To identify unmet needs in CRSwNP from the perspective of CRSwNP patients from the Patient Advisory Board (PAB) of the European Forum for Research and Education in Allergy and Airways diseases (EUFOREA).Methodology: Semi-structured interviews were conducted individually with 15 European patients with CRSwNP and with a disease history of more than 2 years. Patients shared their burden of the disease and frustrations related to CRSwNP care, experiences with key pillars of current treatment options, shortcomings of the current care pathways and recommendations for improvement of care. A panel of 30 members of the Patient Advisory Board reviewed the interview report and provided further input during 2 virtual meetings.Results: CRSwNP patients indicated the need for greater awareness from society and physicians of the disease burden with impact on social function and well-being. Along with a loss of ability to smell and the continuous presence of secretions in the nose, most patients reported poor sleep quality and psychological impact as the most bothersome symptoms. Patients' frustrations relate primarily to the underestimation of the disease burden, the lack of coordination of care and the limited treatment options available to them. Treatment options with oral corticosteroids and/or sinus surgery both have positive and negative aspects, including the lack of long-lasting efficacy. Better coordination of care, more patient-centered care, greater public awareness, increases in research on the disease mechanisms and better therapeutic options would be warmly welcomed by CRSwNP patients.Conclusions: This statement of the EUFOREA Patient Advisory Board on CRSwNP provides novel insights on the underestimation of the burden of CRSwNP and shortcomings of current care. Multiple recommendations made by the patients can underpin action plans for implementation of better care for CRSwNP among all physicians treating patients with this disabling disease.
Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel
Authors: Devillard Chloé D. , Marquette Christophe A. 
Published: October 2021

Since the emergence of regenerative medicine and tissue engineering more than half a century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (&gt;1 cm3) to meet the clinical needs of viable tissue grafts but also for biological research applications. Considerable advancements in biofabrication have been made since Weinberg and Bell, in 1986, created the first blood vessel from collagen, endothelial cells, smooth muscle cells and fibroblasts. The synergistic combination of advances in fabrication methods, availability of cell source, biomaterials formulation and vascular tissue development, promises new strategies for the creation of autologous blood vessels, recapitulating biological functions, structural functions, but also the mechanical functions of a native blood vessel. In this review, the main technological advancements in bio-fabrication are discussed with a particular highlights on 3D bioprinting technologies. The choice of the main biomaterials and cell sources, the use of dynamic maturation systems such as bioreactors and the associated clinical trials will be detailed. The remaining challenges in this complex engineering field will finally be discussed.
miR-371b-5p-Engineered Exosomes Enhances Tumor Inhibitory Effect
Authors: Xue Qiang , Yang Yang , Yang Linlin , Yan Xiaodi , Shen Zihao , Liu Jiajia , Xue Jianhua , Zhao Wei , Liu Xianchen 
Published: October 2021

Background: Exosomes are well-known natural nanovesicles, that represent one of the recently discovered modes of intercellular communication due to their ability to transmit cellular components. Exosomes have been reported to have potential as natural vectors for carrying functional small RNAs and delivering chemotherapeutic agents to diseased cells. In this study, we aimed to investigate the role of exosomes in carrying miRNA for targeting tumor cells.Methods: We present a novel method for engineering exosomes with functional miR-317b-5b to target tumor cells. MiR-317b-5b exerts its anti-tumor function via its expression in tumors. RT-qPCR was performed to assess the levels of miR-371b-5p, FUT-4. Western blot was performed to measure the levels of CD9, CD81, and FUT-4 proteins. Confocal microscopy was used to observe the internalization of miR-317b-5b in tumor cells. CCK-8, EdU, flow cytometry, wound-healing migration and transwell assays were performed to evaluate cell viability, proliferation, migration, and invasion, respectively.Results: Our findings illustrated that miR-317b-5b-loaded engineered exosomes were internalized by tumor cells. MiR-317b-5b was overexpressed in tumor cells treated with miR-317b-5b-loaded engineered exosomes. The internalization of miR-317b-5b in tumor cells was accompanied by changes of cell viability, proliferation, apoptosis, and migratory and invasive capability. We found that miR-317b-5b-loaded engineered exosomes were presence in tumor tissue sections and miR-317b-5b was overexpressed in tumor tissues of osteosarcoma tumor-bearing mice infected with miR-317b-5b-loaded engineered exosomes. MiR-317b-5b-loaded engineered exosomes had the anti-tumor efficiency in vivo.Conclusion: Our findings show that miR-317b-5b-loaded engineered exosomes can be used as nanocarriers to deliver drug molecules such as miR-317b-5b both in vitro and in vivo to exert its anti-tumor functions.
Bridging Carotenoid-to-Bacteriochlorophyll Energy Transfer of Purple Bacteria LH2 With Temperature Variations: Insights From Conformational Changes
Authors: Mao Ruichao , Wang Xiaocong , Gao Jun 
Published: October 2021

Photosynthesis is a key process for converting light energy into chemical energy and providing food for lives on Earth. Understanding the mechanism for the energy transfers could provide insights into regulating energy transfers in photosynthesis and designing artificial photosynthesis systems. Many efforts have been devoted to exploring the mechanism of temperature variations affecting the excitonic properties of LH2. In this study, we performed all-atom molecular dynamics (MD) simulations and quantum mechanics calculations for LH2 complex from purple bacteria along with its membrane environment under three typical temperatures: 270, 300, and 330 K. The structural analysis from validated MD simulations showed that the higher temperature impaired interactions at N-terminus of both α and β polypeptide helices and led to the dissociation of this hetero polypeptide dimer. Rhodopin-β-D-glucosides (RG1) moved centripetally with α polypeptide helices when temperature increased and enlarged their distances with bacteriochlorophylls molecules that have the absorption peak at 850 nm (B850), which resulted in reducing the coupling strengths between RG1 and B850 molecules. The present study reported a cascading mechanism for temperature regulating the energy transfers in LH2 of purple bacteria.