bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Opioid Use Disorder and Related Biomarkers
Authors: Bryant Bianca M. , Eaton Ellen , Li Li 
Published: August 2021

The objective of this systematic review is to examine the relationship between opioid use disorder (OUD) and its related biomarkers, as well as the effects of pharmacotherapy for OUD on biomarkers. The eligibility criteria are the inclusion of human population studies focusing on biomarkers, including the immune system, related to OUD or opioid-related disorders. English, peer reviewed, original research, case studies or case series, and clinical trials were included in this review. Papers were excluded if they met one or more of the following criteria: animal studies, review articles, studies focusing only on OUD or opioid-related disorders without mention of potential biomarkers, studies focusing only on biomarkers and/or the immune system without relating to OUD or opioid-related disorders, and studies that focused on other substance use disorders other than OUD specifically. A PubMed, PsycINFO, and Cochrane databases search on August 25, 2020, yielded 101 results; only 14 articles met inclusion criteria that were included in this review. However, heterogeneity of study definitions and measurements should be noted. Various potential biomarkers indicated systemic, peripheral, and chronic inflammation in patients with OUD or opioid-related disorders. Medications, including buprenorphine and methadone, significantly decreased chronic inflammation in this population. Our results suggest that patients with OUD or opioid-related disorders have potential biomarkers that can be targeted to provide optimal treatment options for this population. A better understanding of potential biomarkers may assist to identify at-risk populations, monitor disease progression and treatment response, and develop therapeutic strategies for OUD.Systematic Review Registration:This review has been registered in PROSPERO (CRD42020202014).
Migrants With Schizophrenia in Forensic Psychiatric Hospitals Benefit From High-Intensity Second Language Programs
Authors: Lutz Maximilian , Streb Judith , Titze Larissa , Büsselmann Michael , Riemat Nadja , Prüter-Schwarte Christian , Dudeck Manuela 
Published: August 2021

Background: As a result of migration, an increasing number of patients in forensic psychiatric hospitals show poor skills in the national language, which can affect their treatment. Improving the second language (L2) of inpatients with schizophrenia may help to enable effective psychotherapy and thus reduce the risk of criminal recidivism and facilitate reintegration into society, for example because of a language-related higher degree of social functioning. For this purpose, a Hessian forensic psychiatric hospital established a ward specialized in L2 acquisition. The ward accommodates up to 21 patients with schizophrenia, who attend an L2 program consisting of 800–900 lessons within 1 year.Aims: The study aimed to evaluate whether patients on the specialized ward (experimental group) achieve at least Common European Framework of Reference (CEFR) level A2 in the L2 program. Additionally, it examined whether language acquisition is better among participants in the experimental group than among those on regular wards (control group).Methods: Achievements in the L2 were assessed by an L2 test 3 times: at the beginning of the program, after 6 months, and after 1 year. The impact of intelligence on achievements in L2 was evaluated using Raven's Standard Progressive Matrices.Results: The experimental group showed significantly better improvement than the control group. Literacy was a significant predictor of improvement in the L2. The majority of the experimental group reached at least CEFR level A2 after 1 year.Conclusions: High-intensity L2 programs are an effective way to improve the L2 of inpatients with schizophrenia in forensic psychiatric hospitals.
Anxiety Regarding COVID-19 Is Related to Attentional Control: The Mediating Role of Anxiety Sensitivity
Authors: Guo Yawen , Yang Haibo , Elhai Jon , McKay Dean 
Published: August 2021

Background: As an emergent public health event, COVID-19 has had a significant impact on mental health, particularly causing anxiety. Some cognitive-affective related studies have demonstrated that attentional control is related to levels of anxiety. More specifically, recent research has shown that anxiety sensitivity is uniquely associated with mental health responses to COVID-19. The aim of the current study was to investigate the role of anxiety sensitivity during COVID-19 outbreak period, especially physical and cognitive concerns, in relation to attentional control and anxiety.Methods: It is a questionnaire study. A total of 464 participants were recruited through online sampling between February and March, 2020. They were surveyed by the Attentional Control Scale (ATTC), Anxiety Sensitivity Index-3 (ASI-3) and Depression Anxiety Stress Scale-21 (DASS-21). Data were analyzed using descriptive statistics and correlation analysis. We also tested the mediating effect.Results: The results showed that attentional control is negatively correlated with physical concern, cognitive concern and anxiety. And results support that physical and cognitive concerns play a mediating role between attentional control and anxiety.Conclusions: Anxiety sensitivity plays a mediating role between attentional control and anxiety. These findings can help effective prevention and intervention of anxiety.
Modeling the Multidimensional Predictors of Multisite Musculoskeletal Pain Across Adulthood—A Generalized Estimating Equations Approach
Authors: Ahlholm Ville-Heikki , Rönkkö Viljami , Ala-Mursula Leena , Karppinen Jaro , Oura Petteri 
Published: August 2021

Background: Multisite pain is commonly chronic and often lacks its initial role as a potential tissue damage signal. Chronic pain among working-age individuals is a risk for disability and imposes a major burden on health care systems and society. As effective treatments for chronic pain are largely lacking, better identification of the factors associated with pain over working years is needed.Methods: Members of the Northern Finland Birth Cohort 1966 participated in data collection at the ages of 31 (n = 4,028) and 46 (n = 3,429). Using these two time points, we performed a multivariable analysis of the association of socioeconomic, occupational, psychological and lifestyle factors (i.e., low education, living alone, low household income, unemployment, occupational physical exposures [hard physical labor, leaning forward, back twisting, constant moving, lifting loads of ≥ 1 kg], physical inactivity, regular smoking, regular drinking, overweight, and psychiatric symptoms) with the number of musculoskeletal pain sites (i.e., upper extremity, lower extremity, lower back, and the neck-shoulder region; totalling 0–4 pain sites). The data were analyzed using generalized estimating equations.Results: At the age of 31, multisite pain was reported by 72.5% of men and 78.6% of women. At the age of 46, the prevalence of multisite pain was 75.7% among men and 82.7% among women. Among men, the number of pain sites was positively associated with age (rate ratio 1.05, 95% confidence interval 1.01–1.08), low household income (1.05, 1.01–1.08), unemployment (1.13, 1.06–1.19), any occupational exposure (1.17, 1.12–1.22), regular smoking (1.06, 1.02–1.11), and psychiatric symptoms (1.21, 1.17–1.26). Among women, the number of pain sites was positively associated with age (1.06, 1.04–1.10), unemployment (1.10, 1.05–1.15), any occupational exposure (1.10, 1.06–1.13), regular smoking (1.06, 1.02–1.10), overweight (1.08, 1.05–1.11), and psychiatric symptoms (1.19, 1.15–1.22); living alone was negatively associated with the number of pain sites (0.95, 0.91–0.99).Conclusion: Of the studied predictors, psychiatric symptoms, occupational physical exposures and unemployment were most strongly associated with multisite pain among both sexes. The results of this study deepen the understanding of the underlying factors of and comorbidities behind multisite pain, and help develop pain relief and rehabilitation strategies for working-age individuals with multisite pain.
Novel Clinimetric Toolset to Quantify the Stability of Blood Pressure and Its Application to Evaluate Cardiovascular Function After Spinal Cord Injury
Authors: Mesbah Samineh , Legg Ditterline Bonnie , Wang Siqi , Wu Samuel , Weir Joseph , Wecht Jill , Forrest Gail , Harkema Susan , Ugiliweneza Beatrice 
Published: August 2021

Profound dysfunction of the cardiovascular system occurs after spinal cord injury (SCI), which is a leading cause of mortality in this population. Most individuals with chronic SCI experience transient episodes of hypotensive and hypertensive blood pressure in response to daily life activities. There are currently limited tools available to evaluate the stability of blood pressure with respect to a reference range. The aim of this study was to develop a clinimetric toolset for accurately quantifying stability of the blood pressure measurements and taking into consideration the complex dynamics of blood pressure variability among individuals with SCI. The proposed toolset is based on distribution of the blood pressure data points within and outside of the clinically recommended range. This toolset consists of six outcome measures including 1) total deviation of the 90% of the blood pressure data points from the center of the target range (115 mmHg); 2) The area under the cumulative distribution curve starting from the percentage of blood pressure measurements within the range, and the percentage of values within symmetrically expanded boundary ranges, above and below the target range; 3) the slope of the cumulative distribution curve that is calculated by fitting an exponential cumulative distribution function and the natural logarithm of its rate parameter; 4) its x- and 5) y-axis intercepts; and 6) the fitting error. These outcome measures were validated using blood pressure measurements recorded during cardiovascular perturbation tests and prolonged monitoring period from individuals with chronic SCI and non-injured controls. The statistical analysis based on the effect size and intra-class correlation coefficient, demonstrated that the proposed outcome measures fulfill reliability, responsiveness and discrimination criteria. The novel methodology proposed in this study is reliable and effective for evaluating the stability of continuous blood pressure in individuals with chronic spinal cord injury.
Ruptured Suprasellar Dermoid Cyst Treated With Lumbar Drain to Prevent Postoperative Hydrocephalus: Case Report and Focused Review of Literature
Authors: Blitz Sarah E. , Bernstock Joshua D. , Dmytriw Adam A. , Ditoro Daniel Francis , Kappel Ari D. , Gormley William B. , Peruzzi Pierpaolo 
Published: August 2021

Background: Ruptured intracranial dermoid cysts are extremely rare. Standard treatment consists of endonasal decompression or craniotomy with evacuation and copious irrigation of subarachnoid spaces to remove any disseminated cystic contents. Disseminated fat particles in the subarachnoid space may be the cause of further sequalae, including the subsequent development of chemical meningitis and hydrocephalus. Here, we present a case of ruptured suprasellar dermoid cyst treated with craniotomy for emergent optic nerve decompression, followed by postoperative hydrocephalus successfully treated with lumbar drain.Case description: We describe a 30-year-old man with a history of migraines who presented with acute onset of headache, photophobia, nausea, vomiting, and vision loss in the left eye. Head CT and brain MRI demonstrated a ruptured suprasellar dermoid cyst with associated mass effect on the optic nerves and frontal lobes as well as fat attenuation material within the subarachnoid spaces. The patient underwent left frontotemporal craniotomy for cyst resection and developed non-obstructive hydrocephalus on postoperative day 1, refractory to external ventricular drainage. Placement of a lumbar drain cleared the subarachnoid space of debris derived from the ruptured dermoid cyst, and the hydrocephalus resolved. The patient did not require permanent CSF diversion.Conclusions: Intracranial dermoid cysts are uncommon, and rupture is a rare event. Standard surgical treatment with craniotomy for evacuation may leave disseminated dermoid contents and fat particles throughout the subarachnoid spaces. We highlight a case of ruptured suprasellar dermoid cyst with postoperative communicating hydrocephalus treated with lumbar drain when external ventricular drain (EVD) was ineffective. Review of the current literature reveals inconsistent findings on the effects of remaining fat particles. In cases with clinical evidence of increased intracranial pressure due to non-obstructive hydrocephalus attributable to chemical meningitis, temporary lumbar drainage is an option to be considered before committing the patient to permanent shunting.
Measurement of NORM in Building Materials to Assess Radiological Hazards to Human Health and Develop the Standard Guidelines for Residents in Thailand: Case Study in Sand Samples Collected from Seven Northeastern Thailand Provinces
Authors: Sola Phachirarat , Injarean Uthaiwan , Picha Roppon , Kranrod Chutima , Kukusamude Chunyapuk , Tokonami Shinji 
Published: August 2021

A total of 223 sand samples collected from seven provinces in Northeastern Thailand were analyzed for their gamma radioactivity from naturally occurring radioactive materials (NORMs), and the data were used to calculate the concentrations of Ra-226, Th-232, and K-40. Radiological safety indicators such as the indoor external dose rates (Din), the annual indoor effective dose (Ein), the activity concentration index (I), the radium equivalent activity (Raeq), the external hazard index (Hex), the internal haphazard index (Hin), and the excess lifetime cancer risk (ELCR) were calculated. The activity concentrations were found to be 36 ± 10 Bq/kg for Ra-226, 2.64 ± 0.58 Bq/kg for Th-232, and 323 ± 168 Bq/kg for K-40. Din is 62 ± 23 nGy/h. The Ein is 0.30 ± 0.11 mSv/y. The activity concentrations and other indicators were reported by each province and compared with the safety standards and are found to be within the safe limits in this study. The results can be used to develop the standard guideline levels for choosing building materials in Thailand.
Effects of Epichloë sinensis Endophyte and Host Ecotype on Physiology of Festuca sinensis under Different Soil Moisture Conditions
Authors: Xu Wenbo , Li Miaomiao , Lin Weihu , Nan Zhibiao , Tian Pei 
Published: August 2021

This study explored the effects of the Epichloë sinensis endophyte on growth, photosynthesis, ionic content (K+ and Ca2+), phytohormones (abscisic acid—ABA, cytokinin—CTK, indolE−3-acetic acid—IAA, and gibberellin—GA), and elements—C, N, P (in the shoot and root) in two ecotypes of Festuca sinensis (ecotypes 111 and 141) under different soil water conditions (35% and 65% relative saturation moisture content (RSMC)). The results showed that 35% RSMC inhibited the plants’ growth, and compared with 65% RSMC, there was a significant (p < 0.05) decrease in the growth and photosynthesis indices, the contents of CTK and GA, Ca2+ concentration, and the contents of C, N, and P (in both the aboveground and underground parts) under 35% RSMC. E. sinensis had beneficial effects on host growth and stress tolerance. Under both 35% and 65% RSMC, the presence of E. sinensis significantly (p < 0.05) increased host plant height, tiller number, root length, root volume, shoot dry weight, chlorophyll content, and the rate of photosynthesis of both ecotypes. Furthermore, the shoot C, N, and P contents in plants infected with E. sinensis (E+) from the two ecotypes, under both conditions of RSMC, were significantly (p < 0.05) higher than those in corresponding plants that were not infected with E. sinensis (E−). Under 35% RSMC, the contents of ABA, K+, Ca2+, and root P contents in E+ plants were significantly (p < 0.05) higher than those in corresponding E− plants in both ecotypes. However, under 65% RSMC, root C, N, and P contents in E+ plants of ecotype 111 and 141 were significantly (p < 0.05) higher than those in corresponding E− plants. In addition, the host ecotype also had effects on host growth and stress tolerance; the growth and photosynthetic indices of ecotype 141 were significantly (p < 0.05) higher than those of ecotype 111 under 35% RSMC, which suggested that ecotype 141 is more competitive than ecotype 111 under water deficiency conditions. These findings suggest that the endophyte improved the host plant resistance to water deficiency by maintaining the growth of the plant, improving photosynthesis, accumulating K+ and Ca2+, promoting nutrient absorption, and adjusting the metabolism of plant hormones.
КРИТЕРІЇ ОЦІНКИ ТА КЛІНІЧНІ ХАРАКТЕРИСТИКИ СТАНУ СЛИЗОВОЇ ОБОЛОНКИ ПОРОЖНИНИ РОТА І ПАРОДОНТА ПРИ ЗУБНОМУ ПРОТЕЗУВАННІ У ПАЦІЄНТІВ, ЩО СТРАЖДАЮТЬ НА ГЕНЕРАЛІЗОВАНИЙ ПАРОДОНТИТ У СТАДІЇ СТАБІЛІЗАЦІЇ
Authors: Іщенко П. В. 
Published: August 2021

Актуальність. Для успішного ортопедичного лікування патологій зубних рядів необхідно в найбільш ран-ній термін діагностувати навіть незначні запальні процеси слизової оболонки, що з’являються в порожнині рота й тканинах пародонту.Це дає можливість провести відповідне лікування запальних станів на їх почат-кових стадіях і, що головне, в короткий термін. В свою чергу це сприяє скороченню строків адаптації слизової оболонки порожнини рота й спровокованого пародонту до нових виготовлених незнімних конструкцій. Тому що при явищах гострого, а тим більше хронічного запалення ці строки збільшуються.
Мета. Дослідити тканини пародонту на предмет запалення в зоні відповідальності ортопедичних конс-трукцій.
Матеріали та методи. Хронічну запальну реакцію виявляли після зняття старих незнімних ортопедичних конструкцій (коронок і мостоподібних протезів) у 40 пацієнтів у віці від 18 до 60 років. З них 18 (45 %) чолові-ків та 22 (55 %) жінки. Хворі були розподілені на дві підгрупи: основну та контрольну.
Результати. При виділенні основних етіологічних факторів, що призводять до запальних змін слизової оболонки порожнини рота й пародонта при заміщенні дефектів зубних рядів незнімними ортопедичними конструкціями, нами враховані та виділені наступні. Це можливість травматизації слизової оболонки маргі-нальних ясен при занадто глибокому препаруванні при формуванні підясневого уступу, на етапі перевірки коро-нок, ковпачків і каркасів мостоподібних протезів при невідповідності периметра краю коронки або ковпачка периметру коло ясневої частини зуба, при невідповідності довжини краю коронки або ковпачка, що поринає в зубоясневу борозну, її глибині, перевантаження пародонта опорних зубів, що виникає зразу після фіксації виго-товлених незнімних конструкцій.
Висновки: Таким чином, основними етілогічними факторами, що приводять до патологічних змін слизової оболонки порожнини рота й пародонта, що виявляються на клінічних етапах лікування незнімними ортопеди-чними конструкціями у пацієнтів, що страждають генералізованим пародонтитом у стадії стабілізації, були наступні: 1) хронічна травма слизової оболонки маргінальних ясен; 2) перевантаження пародонта опорних зу-бів; 3) механічна травма крайового пародонта, що наноситься при препаруванні твердих тканин опорних зу-бів; 4) механічна травма крайового пародонта, при перевірці коронок та каркасів протезів.
The Relationship between Organizational Factors and Timely Cardiac Catheterization Rate in ST-segment Elevation Myocardial Infarction Patients of Hospitals in Thailand
Authors: Vichairuangthum Kitigon , Jarujittipant Pisamai , Veerayannon Kietchai 
Published: August 2021

Introduction: This descriptive study aimed to study an association between the level of readiness of administrative factors and the timely cardiac catheterization rate of patients with acute ischemic heart disease in hospitals in Thailand.
Materials and methods: The target population was 1,180 hospitals that serving heart disease in Thailand. Data were collected by using a questionnaire. A total of 1,022 response data were obtained. The statistics used to analyze the data were frequency, percentage, mean, standard deviation, and correlation was analyzed by multiple regression analysis.
Results: The organizational factors, which consisted of personnel, finance, supporting, and management factors, had overall average readiness at a high level (x̄ = 3.34, S.D. = 0.27). While budget sufficiency was at a low level (x̄ = 2.43, S.D. = 0.43). All factors were significantly related to the timely cardiac catheterization rate, as follows: management factor (Adjust R2 = 0.442), personnel factor (Adjust R2 = 0.244), supporting factor (Adjust R2 = 0.212) and financial factor (Adjust R2 = 0.091).
Conclusion: Therefore, the Thai Ministry of Public Health should provide adequate support for organizational factors, especially in terms of budget sufficiency.
The Relationship Between Modified Rodnan Skin Score (mRSS) With Pulmonal Hypertension and Lung Fibrosis in Systemic Sclerosis Patients
Authors: Rohman Syaifur , Rakhma Yanti Hellmi  , Friska Anggraini HS  
Published: August 2021

Background: Systemic sclerosis (SSc) is a connective tissue disease, which affects the skin, blood vessels, heart, lungs, kidneys, gastrointestinal tract and musculoskeletal system. The manifestations in blood vessels include pulmonary hypertension which can be seen from echocardiography, while the manifestations to the lungs in the form of pulmonary fibrosis are examined by high-resolution computed tomography (HRCT). Modified Rodnan Skin Score (mRSS) a method for measuring skin thickness in SSc patients.
Objective: This study aims to determine the relationship between mRSS and pulmonary hypertension and pulmonary fibrosis in SSc patients.
Methods and Materials: Research with a cross sectional approach at Dr Kariadi Hospital. There were 23 study subjects with SSc patients having their mRSS measured by a rheumatologist and an HRCT examination by a radiologist to see the percent of lung damage and echocardiographic examination by a cardiologist to measure the Tricuspid Regurgitation Velocity Maximum (TRV Max) as a marker of pulmonary hypertension. Normality test using Saphiro-Wilk. The Spearman rank correlation test was used to analyze the relationship between the mRSS score, pulmonary hypertension and pulmonary fibrosis.
Results: The proportion of study subjects with a mean age of 40.39 years, women, and 4.43 years of illness. The mean mRSS score was 17.43. Examination of pulmonary hypertension from echocardiography found most of the light category 95.6%, heavy category 4.4%, while the HRCT examination found pulmonary fibrosis of 86.9%, normal 13.1%. There are significant relationship between mRSS and pulmonary fibrosis (r = 0.485, p = 0.019), and significant relationship between pulmonary hypertension (r = 0.63, p = 0.001)
Conclusion: There is a significant relationship between mRSS, pulmonary fibrosis and pulmonary hypertension.