bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Analysis and Prediction Model for Pulmonary Sarcomatoid Carcinoma Based on SEER Database
Authors: Chen Mingjing , Yang Qiao , Xu Zihan , Luo Bangyu , Li Feng , Yu Yongxin , Sun Jianguo 
Published: May 2021

ObjectiveThis study aimed to investigate the incidence of the pulmonary sarcomatoid carcinoma (PSC), to compare the clinical characteristics and overall survival (OS) of patients with PSC and those with other non-small-cell lung cancer (oNSCLC), so as to analyze the factors affecting the OS of patients with PSC and construct a nomogram prediction model.MethodsData of patients with PSC and those with oNSCLC diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results database were collected. The age-adjusted incidence of PSC was calculated. The characteristics of patients with PSC and those with oNSCLC were compared, then the patients were matched 1:2 for further survival analysis. Patients with PSC were randomly divided into training set and testing set with a ratio of 7:3. The Cox proportional hazards model was used to identify the covariates associated with the OS. Significant covariates were used to construct the nomogram, and the C-index was calculated to measure the discrimination ability. The accuracy of the nomogram was compared with the tumor–node–metastasis (TNM) clinical stage, and the corresponding area under the curve was achieved.ResultsA total of 1049 patients with PSC were enrolled, the incidence of PSC was slowly decreased from 0.120/100,000 in 2004 to 0.092/100,000 in 2015. Before PSM, 793 PSC patients and 191356 oNSCLC patients were identified, the proportion of male, younger patients (&lt;65 years), grade IV, TNM clinical stage IV was higher in the PSC. The patients with PSC had significantly poorer OS compared with those with oNSCLC. After PSM, PSC still had an extremely inferior prognosis. Age, sex, TNM clinical stage, chemotherapy, radiotherapy, and surgery were independent factors for OS. Next, a nomogram was established based on these factors, and the C-indexs were 0.775 and 0.790 for the training and testing set, respectively. Moreover, the nomogram model indicated a more comprehensive and accurate prediction than the TNM clinical stage.ConclusionsThe incidence of PSC was slowly decreased. PSC had a significantly poor prognosis compared with oNSCLC. The nomogram constructed in this study accurately predicted the prognosis of PSC, performed better than the TNM clinical stage.
CircKEAP1 Suppresses the Progression of Lung Adenocarcinoma via the miR-141-3p/KEAP1/NRF2 Axis
Authors: Wang Yanbo , Ren Fenghai , Sun Dawei , Liu Jing , Liu BenKun , He YunLong , Pang Sainan , Shi BoWen , Zhou FuCheng , Yao Lei , Lang YaoGuo , Xu ShiDong , Wang JunFeng 
Published: May 2021

BackgroundLung cancer is the leading cause of death from cancer, and lung adenocarcinoma (LUAD) is the most common form. Despite the great advances that has been made in the diagnosis and treatment for LUAD, the pathogenesis of LUAD remains unclear. In this study, we aimed to identify the function of circKEAP1 derived from the exon of KEAP1 in LUAD.MethodsThe expression profiles of circRNAs in LUAD tissues and adjacent non-tumor tissues were analyzed by Agilent Arraystar Human CircRNA microarray. The levels and prognostic values of circKEAP1 in tissues and cancer cell lines were determined by quantitative real-time PCR (qRT-PCR). Subsequently, the effects of circKEAP1 on tumor growth were investigated by functional experiments in vitro and in vivo. Mechanistically, the dual luciferase reporter assay, RNA pull-down, and RNA immunoprecipitation experiments were performed to confirm the interaction between circKEAP1 and miR-141-3p in LUAD.ResultsWe found circKEAP1 was significantly downregulated in LUAD tissues and repressed tumor growth both in vitro and in vivo. Mechanistically, circKEAP1 competitively binds to miR-141-3p and relive miR-141-3p repression for its host gene, which activated the KEAP1/NRF2 signal pathway, and finally suppresses the tumor progress. Our findings suggest that circKEAP1 inhibits LUAD progression through circKEAP1/miR-141-3p/KEAP1 axis and it may serve as a novel method for the treatment of LUAD.
Efficacy of Antimicrobial-Impregnated Catheters for Prevention of Bloodstream Infections in Pediatric Patients: A Meta-Analysis
Authors: Lai Li , Yue Xuan 
Published: May 2021

Background: Multiple Randomized controlled trials (RCTs) have evaluated the efficacy of antimicrobial-impregnated catheters to prevent catheter-related bloodstream infections (CRBSI). However, the RCTs showed contradictory results, the studies were limited in sample size and methodology quality. Thus, we conducted a meta-analysis to overcome these RCT limitations.Methods: We designed a meta-analysis of RCTs comparing antimicrobial-impregnated and conventional catheters for the prevention of CRBSI. We conducted a detailed search of various databases for RCTs published before November 2019. We calculated mean differences (MDs) and pooled odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model.Results: We included five RCTs with a total of 2,294 patients. The incidence of CRBSI between the two groups was 0.50 (95% CI, 0.19–1.27), with evidence of heterogeneity (I2 = 55%). The difference was not statistically significant (p = 0.15). On subgroup analysis based on the age of the sample, there was no difference in the rate of CRBSI in the neonatal population [0.42 (95% CI, 0.08–2.27 I2 = 61% p = 0.31] as well as pediatric population [0.45 (95% CI, 0.12–1.67 I2 = 39% p = 0.23]. The summary OR on the incidence of catheter colonization between antimicrobial-impregnated and conventional catheters was 0.64 (95% CI, 0.17–2.35), with no evidence of heterogeneity (I2 = 0%) and a non-significant difference (p = 0.50).Conclusions: To conclude, analysis of a limited number of heterogeneous studies mostly with a small sample indicates that the CRBSI and catheter colonization rates are similar between conventional and antimicrobial-impregnated catheters in the pediatric and neonatal population. There is an urgent need for large-scale RCTs focusing on different antimicrobial-impregnated catheters in these patients to further enhance current evidence.
Oncologists' Communication About Uncertain Information in Second Opinion Consultations: A Focused Qualitative Analysis
Authors: van Someren Jamie L. , Lehmann Vicky , Stouthard Jacqueline M. , Stiggelbout Anne M. , Smets Ellen M. A. , Hillen Marij A. 
Published: May 2021

Introduction: Uncertainty is omnipresent in cancer care, including the ambiguity of diagnostic tests, efficacy and side effects of treatments, and/or patients' long-term prognosis. During second opinion consultations, uncertainty may be particularly tangible: doubts and uncertainty may drive patients to seek more information and request a second opinion, whereas the second opinion in turn may also affect patients' level of uncertainty. Providers are tasked to clearly discuss all of these uncertainties with patients who may feel overwhelmed by it. The aim of this study was to explore how oncologists communicate about uncertainty during second opinion consultations in medical oncology.Methods: We performed a secondary qualitative analysis of audio-recorded consultations collected in a prospective study among cancer patients (N = 69) who sought a second opinion in medical oncology. We purposively selected 12 audio-recorded second opinion consultations. Any communication about uncertainty by the oncologist was double coded by two researchers and an inductive analytic approach was chosen to allow for novel insights to arise.Results: Seven approaches in which oncologists conveyed or addressed uncertainty were identified: (1) specifying the degree of uncertainty, (2) explaining reasons of uncertainty, (3) providing personalized estimates of uncertainty to patients, (4) downplaying or magnifying uncertainty, (5) reducing or counterbalancing uncertainty, and (6) providing support to facilitate patients in coping with uncertainty. Moreover, oncologists varied in their (7) choice of words/language to convey uncertainty (i.e., “I” vs. “we”; level of explicitness).Discussion: This study identified various approaches of how oncologists communicated uncertain issues during second opinion consultations. These different approaches could affect patients' perception of uncertainty, emotions provoked by it, and possibly even patients' behavior. For example, by minimizing uncertainty, oncologists may (un)consciously steer patients toward specific medical decisions). Future research is needed to examine how these different ways of communicating about uncertainty affect patients. This could also facilitate a discussion about the desirability of certain communication strategies. Eventually, practical and evidence-based guidance needs to be developed for clinicians to optimally inform patients about uncertain issues and support patients in dealing with these.
The Prevalence of Generalized Anxiety Disorder Among Health Care Workers During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis
Authors: Adibi Amir , Golitaleb Mohamad , Farrahi-Ashtiani Iman , Pirani Davoud , Yousefi Kosar , Jamshidbeigi Yousef , Sahebi Ali 
Published: May 2021

Introduction: Health care workers, due to be involved in caring for COVID-19 patients may experience various psychological problems including anxiety disorders. This study aimed to investigate the prevalence of Generalized Anxiety Disorder (GAD) among health care workers during the COVID-19 pandemic by systematic review and meta-analysis.Methods: The PRISMA guideline was used for conducting this study. Related keywords were searched in credited resources including ISC, Magiran, PubMed, Scopus, Web of Science, Cochrane, ProQuest, Science Direct, Google Scholar, and Embase to find the articles published on the prevalence of GAD among health care workers during the COVID-19 pandemic from the first of January to the end of June 2020. Meta-analysis was conducted by the random effects model.Results: In this study, 553 articles were initially identified, from which 19 studies were finally included in the meta-analysis. The results showed that the prevalence of GAD in health care workers based on the GAD-7 and GAD-2 instruments were 32.04% (95% CI: 26.89–37.19, I2 = 98.2%, p &lt; 0.001) and 22.62% (95% CI: 9.01–36.24, I2 = 97.7%, p &lt; 0.001). The overall prevalence of GAD was obtained 30.5% (95% CI: 25.58–35.42, I2 = 98.4%, p &lt; 0.001).Conclusion: This study showed a relatively high GAD prevalence, as one of the fundamental psychological problems, among health care workers during the COVID-19 pandemic. Therefore, health system managers should implement preventive strategies to protect health staff from contracting the virus and monitor them for psychological problems and provide them with supportive measures if necessary.
Overexpression Populus d-Type Cyclin Gene PsnCYCD1;1 Influences Cell Division and Produces Curved Leaf in Arabidopsis thaliana
Authors: Zheng Tangchun , Dai Lijuan , Liu Yi , Li Shuang , Zheng Mi , Zhao Zhongnan , Qu Guan-Zheng 
Published: May 2021

d-type cyclins (CYCDs) are a special class of cyclins and play extremely important roles in plant growth and development. In the plant kingdom, most of the existing studies on CYCDs have been done on herbaceous plants, with few on perennial woody plants. Here, we identified a Populus d-type cyclin gene, PsnCYCD1;1, which is mainly transcribed in leaf buds and stems. The promoter of PsnCYCD1;1 activated GUS gene expression and transgenic Arabidopsis lines were strongly GUS stained in whole seedlings and mature anthers. Moreover, subcellular localization analysis showed the fluorescence signal of PsnCYCD1;1-GFP fusion protein is present in the nucleus. Furthermore, overexpression of the PsnCYCD1;1 gene in Arabidopsis can promote cell division and lead to small cell generation and cytokinin response, resulting in curved leaves and twisted inflorescence stems. Moreover, the transcriptional levels of endogenous genes, such as ASs, KNATs, EXP10, and PHB, were upregulated by PsnCYCD1;1. Together, our results indicated that PsnCYCD1;1 participates in cell division by cytokinin response, providing new information on controlling plant architecture in woody plants.
Flood Inundation Analysis in Penang Island (Malaysia) Based on InSAR Maps of Land Subsidence and Local Sea Level Scenarios
Authors: Gao Guosheng , San Lim Hwee , Zhu Yidan 
Published: May 2021

Penang Island is an important economic center in Malaysia and most of its population live in the coastal areas. Although previous studies have shown that it is vulnerable to rising sea levels, the combination of sea-level rise and local land subsidence would be devastating. Therefore, the objective of this study is to apply the local land subsidence model to estimate the inundated areas which relate to sea level rise by 2100. Land subsidence is quantified by the SBAS-InSAR technique on the basis of Sentinel-1 radar images for both ascending and descending tracks. For the first time, the geostatistical analyst method is used to merge the different track results and create the land subsidence models, the results show this method can maximize land deformation fields and minimize deformation errors. According to the land deformation results, all of the coastlines in the east of the island have differing medium levels of subsidence, especially in reclaimed lands and building areas. Lastly, the bathtub model is used to quantify the inundated areas by combing regional sea-level rise projection and local land subsidence models under CoastalDEM in 2100 projections. The results of this study indicate land subsidence that would increase 2.0% and 5.9% of the inundated area based on the different scenarios by 2100 projections.
Investigation of Structural, Morphological, Resistivity of Novel Electrical Insulator: Industrial Wastes
Authors: M.K Panigrahi 
Published: May 2021

In the present study, the effect of china clays on the sintering, strength and dielectric behavior of electrical ceramic fly ash/china clay (FA/CC) composite insulator is investigated. The different composition of samples containing different china clay (CC) contents of 10, 20, 30, 40, and 50 % are prepared using the uniaxial pressure technique applying 10 MPa pressure. At 1200 °C, for the composition having 40 wt% china clays, the maximum resistivity is calculated and is 39.5 × 107 Ωm. The composite is highly competence with china clays-based insulators. Further, the prepared composite is also analysed using different characterization technique such as x-ray diffraction, field emission scanning electron microscopy with energy dispersive analysis, fourier transformation infra-red spectroscopy, dielctric, and thermo gravimetric analysis. Frequency dielectric value of the composite is estimated at room temperature in the frequency range of 1-500 kHz at room temperature. According to the resistivity and dielectric properties, the composite has enormous potential for the electrical insulator application.
Factors of Quality of Life in a Group of Selected European Union and OECD Countries
Authors: Drastichová Magdaléna , Filzmoser Peter 
Published: May 2021

This work focuses on the evaluation of the factors of quality of life in a sample of 26 countries. Quality of life is a complex, multidimensional concept, which includes various social, cultural, economic, political, demographic and environmental aspects. Regarding this, principal component analysis and regression analysis were chosen as relevant methods to analyse relationships among twenty-five variables related to quality of life, and their rela-tionships with three composite indices reflecting crucial aspects of quality of life, wellbeing and sustainability. These indices, applied as the response variables in the regression analysis, include the inequality-adjusted alter-native of the Human Development Index (IHDI), the Happy Planet Index (HPI), and Healthy Life Years (HLY). The IHDI represents an objective indicator of human development and wellbeing. HLY reflects quality of life in terms of health. The HPI combines the ecological efficiency with which human wellbeing is delivered, while it also includes a subjective measure of wellbeing. Since each of these indices represent different aspects of quality of life to a certain extent, some of the factors (represented by selected indicators) affected them in different ways. After applying a Lasso regression, nine of the 25 indicators – representing crucial factors of quality of life – were identified. Homicide rate (representing the factor of safety) affected all three indices in a negative way, whereas Years in education (representing the factor of education) and Life satisfaction – a subjective indicator of wellbeing representing the dimension of the same name, affected them positively.
JEL Classification: I10, I13, I15, I18, Q01
Penambahan Ampas Sagu Terfermentasi (Metroxylon sago) Terhadap Performa Ayam Kampung Super Fase Starter
Authors: Sudarto Ahmad - , Datau Fahria , Fathan Suparmin 
Published: May 2021

This study aims to determine the performance of super native chickens fed with fermented sago dregs as a substitute for corn in the ration. Super native chickens used in the study were 80 chickens. The research design used a completely randomized design (CRD) with 4 treatments and 4 replications. The treatment in this study was P0 (without a mixture of fermented sago dregs), P1 (rations with an additional 10% fermented sago dregs), P2 (rations with an additional 20% fermented sago dregs), P3 (rations with an additional 30% fermented sago dregs). The variables observed were ration consumption, body weight gain and ration conversion. Based on the analysis of variance, it showed that dietary consumption was not significantly differed (P0,05), while body weight gain and diet conversion were significantly differed (P0,01). Therefore, the use of fermented sago dregs in the ration of super native chickens can significantly affect body weight gain and ration conversion up to the level of 20%.
Performan Itik Lokal Jantan dengan Penggunaan Tepung Daun Beluntas (Pluchea indica L) dalam Ransum
Authors: Wijayanti Dwi , Kumbok Ilyad 
Published: May 2021

The research objective was to determine the use of beluntas leaf flour in rations on the performance of male local ducks. The research was conducted in the Tondo, subdistrict Mantikulore, for 6 weeks, using 80 DOD local male. The study was design using CRD with 4 treatmens and 5 replication. The treatment given was percentage of beluntas leaf flour in the ration, namely P0: ration without the addition of beluntas leaf flour, P1: 2% beluntas leaf flour, P2: 2,5% beluntas leaf flour, P3: 3% beluntas leaf flour. The analysis was used analysis of variance. The results showedthat treatments had a significant effect on ration consumption, had avery significant effect on body weight gain, ration konvertion and income over feed costof male local ducks. The use of beluntas leaf flour up to level of 3%in the ration give the best results on growth performance, ration convertion and Income Over Feed Costof male local ducks.
Analisis Manajemen Risiko Yang Mempengaruhi Kontraktor pada Pelaksanaan Proyek Jalan dan Gedung di Kabupaten Malinau-Kalimantan Utara
Authors: Gulindo Hero Anda 
Published: May 2021

Dalam industri konstruksi yang memiliki beragam jenis proyek dengan besaran volume yang harus dikerjakan, serta rumit dan kompleksnya metode pelaksanaan yang terjadi di lapangan, pasti memiliki beragam jenis risiko yang berpengaruh dalam pelaksanaan konstruksi. Faktor risiko ini timbul dari berbagai sumber, serta bervariasi baik dalam kemungkinan terjadinya, besarnya pengaruh atau dampak yang ditimbulkan. Kontraktor sebagai pihak pelaksana konstruksi pada umumnya akan menghadapi faktor-faktor risiko yang dapat menghambat kesuksesan proyek dan tentunya akan berpengaruh terhadap kinerja kontraktor itu sendiri, agar tetap dapat bersaing dalam dunia konstruksi. Penelitian ini bertujuan untuk mengetahui risiko yang memiliki dampak dan jenis-jenis risiko yang sangat sering terjadi terhadap kinerja kontraktor pada pelaksanaan Proyek infrastruktur Jalan dan proyek bangunan Gedung di Kab. Malinau, dan mengetahui ada tidaknya perbedaan dampak dan jenis risiko yang sering terjadi diproyek infrastruktur jalan dengan proyek bangunan Gedung. Penelitian ini menggunakan metode kuesioner untuk mengumpulkan data yang diperlukan. Kuesioner disebarkan kepada perusahaan- perusahaan kontraktor yang berada di Kab Malinau (Kalimantan Utara). Metode analisis yang digunakan adalah mean, standar deviasi dan Uji T. Dari hasil analisis mean dan standar deviasi kita dapat mengetahui hasil dampak dan jenis-jenis risiko yang sering terjadi mana yang paling berpengaruh pada pelaksanaan proyek Gedung maupun proyek jalan. Pada hasil analisis uji-T mengenai peryataan antara responden proyek konstruksi Gedung dan proyek jalan , didapatkan kesamaan atau tidak terdapat perbedaan yang cukup signifikan pada dampak dan risiko yang sering terjadi antara pelaksanaan proyek konstruksi Gedung dan jalan, nilai signifikan > 0.05 yang berarti terdapat persamaan antara dampak risiko dan risiko yang sering terjadi pada pelaksanaan proyek infrastruktur jalan dan bangunan Gedung.
ANALISIS PEMBINAAN PRESTASI KLUB BULUTANGKIS PB JUNIOR DI KABUPATEN BENGKULU SELATAN
Authors: Wibowo Tito Parta 
Published: May 2021

ABSTRAK Tujuan penelitian ini adalah untuk mengetahui gambaran, faktor Pembinaan Prestasi Bulutangkis PB Junior terhadap atlet, Pelatih, Program latihan, Managemen Organisasi dan Sarana Prasarana pada Cabang olahraga bulutangkis di Kabupaten Bengkulu Selatan. Penelitian ini merupakan penelitian deskriftif yang memiliki makna mendeskripsikan suatu penelitian yang sedang dilaksanakan. Populasi penelitian ini adalah atlet bulutangkis PB Junior Kabupaten Bengkulu Selatan yang berjumlah 20 orang, yaitu: 15 Laki-laki, dan 5 Perempuan. Teknik pengambilan sampel dilakukan dengan teknik total sampling. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dengan menyebarkan angket kepada responden yang menjadi sampel atau dengan metode penyebaran angket atau kuesioner kepada atlet. Analisis data dilakukan dengan mengolah data menggunakan rumus persentase. Kesimpulan penelitian bahwa Pembinaan Prestasi Klub Bulutangkis PB Junior Di Kabupaten Bengkulu Selatan dalam variabel atlet kategori sangat baik (95,00%), variabel Pelatih kategori sangat baik (90,00%), variabel program latihan kategori baik (77,50%), variabel manajemen kategori cukup (60,00%), serta varibel sarana dan prasarana kategori cukup (50,00%).
Optimalisasi Peran Kader Posyandu dalam Deteksi Kesehatan Mata bagi Balita
Authors: Cahyaningsih Oktaviani , Rochmayani Dewi Sari 
Published: May 2021

Melakukan pemeriksaan mata pada anak secara kontinu pada usia 3 -5 tahun sangat perlu dilakukan untuk mendeteksi masalah kesehatan pada anak sejak awal. Pada umumya pemeriksaan mata dilakukan kalau orangtua menangkap gejala awal seperti ada gangguan penglihatan pada anak misalnya kesulitan melihat dari jarak dekat maupun jauh atau juga ada riwayat keluarga yang memiliki masalah mata. Sejatinya, pemeriksaan mata untuk anak-anak sebaiknya dilakukan untuk memastikan mata anak sehat dan tidak memiliki masalah penglihatan yang dapat mengganggu aktifitas anak khususnya saat belajar di sekolah dan berpotensi memengaruhi kesehatan anak dimasa kedepannya. Kegiatan deteksi dini kesehatan mata dengan menggunakan “kartu E” menjadi salah satu strategi sederhana dalam mendeteksi kesehatan mata dimana hal ini tidak pernah dilakukan di Posyandu RW I Kelurahan Palebon Kecamatan Pedurungan. Untuk kelancaran dalam upaya sosialisasi “kartu E” terdapat beberapa kategori pada penyelenggaraanya yaitu terdiri dari ceramah, praktek dan evaluasi dengan sasarannya adalah kader posyandu RW I Kelurahan Palebon yang berjumlah 10 orang. Hasil dalam pemeriksaan kesehatan mata ini adalah rata rata Balita di Posyandu RW I Kelurahan Palebon ini baik, terdapat tambahan ketrampilan kader posyandu dalam melakukan pemeriksaan kesehatan mata.