bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Need of a Leader: Bolesław Piasecki’s Charismatic Leadership in the 1930s
Authors: Mrzygłód Izabela 
Published: June 2021

This article is part of the special cluster, “National, European, Transnational: Far-right activism in the 20th and 21st centuries”, guest edited by Agnieszka Pasieka. Bolesław Piasecki, the leader of the Polish National Radical Movement (RNR), was one of the influential far-right activists in the 1930s. This article examines his political leadership through the lens of Weberian charismatic authority, enhanced by Anthony Ammeter’s framework for analyzing the power dynamics of leadership. Through a close investigation of the development of his political career, the article shows—in contrast to much of the existing literature—that Piasecki’s power was forged through triangular interactions between his skills and influential personality, the expectations and needs of his associates, and as a result of a series of events in which he displayed the ability to wield political impact. This approach sheds light on the ways in which political leadership is reliant on a wider network of relationships and shows that Piasecki’s charismatic authority was to a large extent an image constructed by his closest associates. At the same time, it shows parallels and connections between the RNR and other European fascist movements. This approach enables us to define and specify more precisely the nature of the RNR, and dig deep into the complex dynamics lying behind the final failure of the movement and Piasecki’s leadership.
Re-use of erlotinib in a patient using osimertinib after erlotinib, case report
Authors: Gursoy Pinar 
Published: June 2021

Introduction Most patients with non-small-cell lung cancer tumors that have epidermal growth factor receptor (EGFR) mutations have deletion mutations in exon 19 or exon 21, or both.In recent years, targeted therapies in lung cancer have increased survival, but the development of resistance to these drugs poses a major problem. Thesubstitution of methionineforthreonine at position 790 (T790M) mutation,is primarily responsible for this resistance. However, after osimertinib used in T790M positivepatients treatment options are generally limited to chemotherapy. Case report We reported the efficacy of erlotinib, which we reapplied due to the disappearance of the resistance mutation after osimertinib in a 68-year-old patient using osimertinib after erlotinib. Management and outcome: In the patient using erlotinib due to exon 19 deletion when progression was observed and T790M positivity was detected, osimertinib treatment was initiated. However, when T790M was found to be negative with rebiopsy in progression after osimertinib, a complete response was achieved by restarting erlotinib. Discussion The strategy of restarting erlotinib treatment with negative T790M mutation detected in biopsies of patients with osimertinib resistance may be an acceptable treatment option.
A mixed-methods examination of the gap between intelligence and adaptive functioning in autistic young adults without intellectual disability
Authors: Matthews Nicole L , Christenson Kyla , Kiefer Sarah , Smith Christopher J 
Published: June 2021

This study examined adaptive functioning, strategies used to develop adaptive functioning skills, and areas where additional services could benefit autistic young adults without intellectual disability. Participants were 21 autistic young adults and at least one parent of each young adult. Quantitative analyses replicated previous reports of an adaptive functioning disadvantage relative to intellectual functioning such that adaptive functioning standard scores were significantly lower than intelligence quotient scores. Qualitative analysis utilized grounded theory methodology and yielded a conceptual model describing the nature and development of adaptive functioning in this demographic. Together, findings provide a more nuanced understanding of the gap between intellectual and adaptive functioning in autistic young adults without intellectual disability. Lay abstract Adaptive functioning describes the age-appropriate skills necessary for independent living. Research suggests that autistic children, adolescents, and adults who do not have an intellectual disability demonstrate adaptive functioning challenges relative to their intellectual ability. Thus, even though many of these individuals have the intellectual capacity to excel in mainstream educational and vocational settings, their adaptive functioning challenges may serve as an obstacle to independence. The research on adaptive functioning in autistic adults is focused on statistical analysis of standardized assessments (e.g. parent-report on multiple choice questionnaires). Qualitative research that examines the narratives of young adults and their parents is needed to better understand adaptive functioning in young adults and their resulting service needs. This study combined statistical analysis of standardized assessments with qualitative analysis of interview responses from autistic young adults without intellectual disability and their parents. Findings replicated previous reports of adaptive functioning challenges and identified influences on adaptive functioning development, consequences of independence, and service needs. Taken together, findings indicate the need for interventions and services that facilitate adaptive functioning development in autistic adolescents and young adults and provide insight into potential intervention targets and strategies.
Acculturation and attitudes toward code-switching: A bidimensional framework
Authors: Yim Odilia , Clément Richard 
Published: June 2021

Aims and objectives: Code-switching, the spontaneous switching from one language to another within a single speech event, is often performed by bilinguals who have mastered a communicative competence in two languages. It is also a social strategy – using linguistic cues as a means to index social categories and group solidarity. Code-switching is, therefore, linked to attitudes, seen as a reflection of the speaker and their values and identities. Traditionally perceived negatively, attitudes toward code-switching have been shown to be acceptable in certain cases, such as in multilingual contexts. However, it has yet to be determined empirically whether attitudes toward code-switching are associated with individual social characteristics, including cultural identity and identity negotiation. Adopting the bidimensional model of acculturation, the goal of the study was to investigate the relationships among cultural identity and code-switching attitudes. Specifically, we sought to examine whether the bidimensional framework can be used to characterize and distinguish biculturals and whether such distinctions result in differences in code-switching attitudes and other related factors. Data and analysis: Cantonese-English bilinguals ( n = 67) reported their language background and completed questionnaires relating to identity and code-switching. Findings: The findings suggest the bidimensional model was successful in classifying biculturals versus non-biculturals and, additionally, that biculturals could be differentiated according to their strength of cultural identification, which we designated as strong biculturals, Canadian-oriented biculturals, Chinese-oriented biculturals, and weak biculturals. Findings also revealed significant group differences in code-switching attitudes and other factors, such as code-switching comfort and preference, among the bicultural subgroups. Implications: The study supports the hypothesis that code-switching is linked to bicultural identity. The results conclude that a more nuanced classification of biculturals is meaningful, as individual differences in cultural identification among biculturals are linked to significant differences in code-switching comfort, code-switching preference, code-switching attitudes, and multicultural attitudes.
Transcriptome Analysis and the Prognostic Role of NUDC in Diffuse and Intestinal Gastric Cancer
Authors: Jeong Sang-Ho , Park Miyeong , Park Sun Yi , Park Jiho , Kim Tae-Han , Lee Young-Joon , Jung Eun-Jung , Ju Young-tae , Jeong Chi-Young , Kim Ju-Yeon , Ko Gyung Hyuck , Kim Minhye , Nam Ki Taek , Goldenring James R. 
Published: June 2021

Introduction: There have been few studies about gene differences between patients with diffuse-type gastric cancer and those with intestinal-type gastric cancer. The aim of this study was to compare the transcriptomes of signet ring cell gastric cancer (worst prognosis in diffuse-type) and well-differentiated gastric cancer (best prognosis in intestinal-type); NUDC was identified, and its prognostic role was studied. Materials and Methods: We performed next-generation sequencing with 5 well-differentiated gastric cancers and 3 of signet ring cell gastric cancer surgical samples. We performed gene enrichment and functional annotation analysis using the Database for Annotation, Visualization and Integrated Discovery bioinformatics resources. Immunohistochemistry was used to validate NUDC expression. Results: Overall, 900 genes showed significantly higher expression, 644 genes showed lower expression in signet ring cell gastric cancer than in well-differentiated gastric cancers, and there was a large difference in adhesion, vascular development, and cell-to-cell junction components between the 2 subtypes. We performed variant analysis and found 52 variants and 30 cancer driver genes, including NUDC. We analyzed NUDC expression in gastric cancer tissue and its relationship with prognosis. Cox proportional hazard analysis identified T stage, N stage, and NUDC expression as independent risk factors for survival ( P < 0.05). The overall survival of the NUDC-positive group was significantly higher (53.2 ± 0.92 months) than that of the NUDC-negative group (44.6 ± 3.7 months) ( P = 0.001) in Kaplan-Meier survival analysis. Conclusion: We found 30 cancer driver gene candidates and found that the NUDC-positive group showed significantly better survival than the NUDC-negative group via variant analysis.
Novel Experimental Technique to Create Size-Controlled Retroperitoneal Bleeding in the Infrarenal Aorta of Anesthetized Pigs
Authors: Pirouzram Artai , Hamam Leonardo , Wallin Göran , Larzon Thomas , Nilsson Kristofer F. 
Published: June 2021

Objective Rupture of abdominal aortic aneurysm (rAAA) with a contained retroperitoneal hematoma is potentially fatal. Physiological studies are difficult to perform in patients suffering from life-threatening conditions such as rAAA. A translational model of the condition is therefore needed. The aim was to develop and validate an endovascular animal model for retroperitoneal bleeding of the abdominal aorta with contained hematoma. Methods In anesthetized pigs, a puncture hole was made in the posterolateral portion of the infrarenal aorta by an Outback re-entry catheter device. The hole was gradually enlarged using angioplasty balloons to a specific diameter of either 4 mm ( n = 6), 6 mm ( n = 7), or 8 mm ( n = 6). Onset of bleeding was verified by angiography and macroscopically examined on completion of the experiments. Survival up to 180 min was the primary outcome. Hemodynamic and metabolic markers in arterial blood were secondary outcomes. Results Aortic injury with a contained retroperitoneal hematoma was achieved in all animals. Survival rate at 180 min after onset of bleeding was higher in the 4 mm group compared to the 6 mm ( P = 0.021) and 8 mm groups ( P = 0.002), but not when comparing the 6 mm and 8 mm groups. Systemic hypotension, arterial acidosis, and lactatemia were provoked in the 6 mm and 8 mm groups but not in the 4 mm group. Conclusions A porcine model for a controlled contained left posterolateral retroperitoneal bleeding was created using endovascular methods and validated. This model makes it possible to study the pathophysiology of a retroperitoneal hematoma.
Telemedicine Implementation in COVID-19 ICU: Balancing Physical and Virtual Forms of Visibility
Authors: Pilosof Nirit Putievsky , Barrett Michael , Oborn Eivor , Barkai Galia , Pessach Itai M. , Zimlichman Eyal 
Published: June 2021

Objective: This case study examines the implementation of inpatient telemedicine in COVID-19 intensive care units (ICUs) and explores the impact of shifting forms of visibility on the management of the unit, staff collaboration, and patient care. Background: The COVID-19 crisis drove healthcare institutions to rapidly develop new models of care based on integrating digital technologies for remote care with transformations in the hospital-built environment. The Sheba Medical Center in Israel created COVID-19 ICUs in an underground structure with an open-ward layout and telemedicine control rooms to remotely supervise, communicate, and support the operations in the contaminated zones. One unit had a physical visual connection between the control room and the contaminated zone through a window, while the other had only a virtual connection with digital technologies. Methods: The findings are based on semistructured interviews with Sheba medical staff, telemedicine companies, and the architectural design team and observations at the COVID-19 units during March–August 2020. Results: The case study illustrates the implications of virtual and physical visibility on the management of the unit, staff collaboration, and patient care. It demonstrates the correlations between patterns of visibility and the users’ sense of control, orientation in space, teamwork, safety, quality of care, and well-being. Conclusions: The case study demonstrates the limitations of current telemedicine technologies that were not designed for inpatient care to account for the spatial perception of the unit and the dynamic use of the space. It presents the potential of a hybrid model that balances virtual and physical forms of visibility and suggests directions for future research and development of inpatient telemedicine.
Validity of load rate estimation using accelerometers during physical activity on an anti-gravity treadmill
Authors: Nazirizadeh Susan , Stokes Maria , Arden Nigel K , Forrester Alexander IJ 
Published: June 2021

Introduction A simple tool to estimate loading on the lower limb joints outside a laboratory may be useful for people who suffer from degenerative joint disease. Here, the accelerometers on board of wearables (smartwatch, smartphone) were used to estimate the load rate on the lower limbs and were compared to data from a treadmill force plate. The aim was to assess the validity of wearables to estimate load rate transmitted through the joints. Methods Twelve healthy participants (female n = 4, male n = 8; aged 26 ± 3 years; height: 175 ± 15 cm; body mass: 71 ± 9 kg) carried wearables, while performing locomotive activities on an anti-gravity treadmill with an integrated force plate. Acceleration data from the wearables and force plate data were used to estimate the load rate. The treadmill enabled 7680 data points to be obtained, allowing a good estimate of uncertainty to be examined. A linear regression model and cross-validation with 1000 bootstrap resamples were used to assess the validation. Results Significant correlation was found between load rate from the force plate and wearables (smartphone: [Formula: see text]; smartwatch: [Formula: see text]). Conclusion Wearables’ accelerometers can estimate load rate, and the good correlation with force plate data supports their use as a surrogate when assessing lower limb joint loading in field environments.
Single limb cable driven wearable robotic device for upper extremity movement support after traumatic brain injury
Authors: Kadivar Zahra , Beck Christopher E , Rovekamp Roger N , O’Malley Marcia K 
Published: June 2021

Introduction Recently, soft exosuits have been proposed for upper limb movement assistance, most supporting single joint movements. We describe the design of a portable wearable robotic device (WRD), “Armstrong,” able to support three degrees-of-freedom of arm movements, and report on its feasibility for movement support of individuals with hemiparesis after traumatic brain injury (TBI). Methods We introduce Armstrong and report on a pilot evaluation with two male individuals post-TBI (T1 and T2) and two healthy individuals. Testing involved elbow flexion/extension with and without robotic-assisted shoulder stabilization; shoulder abduction with and without robotic-assisted elbow stabilization; and assisted shoulder abduction and flexion. Outcome measures included range of motion and root mean square trajectory and velocity errors. Results TBI subjects performed active, passive, hybrid and active assistive movements with Armstrong. Subjects showed improvements in movement trajectory and velocity. T1 benefited from hybrid, active, and assistive modes due to upper extremity weakness and muscle tone. T2 benefited from hybrid and assistive modes due to impaired coordination. Healthy subjects performed isolated movements of shoulder and elbow with minimal trajectory and velocity errors. Conclusions This study demonstrates the safety and feasibility of Armstrong for upper extremity movement assistance for individuals with TBI, with therapist supervision.
Feasibility of a real-time pattern-based kinematic feedback system for gait retraining in pediatric cerebral palsy
Authors: Liu Xuan , Oliveira Nuno , Ehrenberg Naphtaly , Cheng JenFu , Bentley Katherine , Blochlinger Sheila , Shoval Hannah , Barrance Peter 
Published: June 2021

Introduction Visual biofeedback of lower extremity kinematics has the potential to enhance retraining of pathological gait patterns. We describe a system that uses wearable inertial measurement units to provide kinematic feedback on error measures generated during periods of gait in which the knee is predominantly extended (‘extension period’) and flexed (‘flexion period’). Methods We describe the principles of operation of the system, a validation study on the inertial measurement unit derived knee flexion angle on which the system is based, and a feasibility study to assess the ability of a child with cerebral palsy to modify a gait deviation (decreased swing phase knee flexion) in response to the feedback. Results The validation study demonstrated strong convergent validity with an independent measurement of knee flexion angle. The gait pattern observed during training with the system exhibited increased flexion in the flexion period with maintenance of appropriate extension in the extension period. Conclusions Inertial measurement units can provide robust feedback during gait training. A child with cerebral palsy was able to interpret the novel two phase visual feedback and respond with rapid gait adaptation in a single training session. With further development, the system has the potential to support clinical retraining of deviated gait patterns.
Governance of global value chains after the Covid-19 pandemic: A new wave of regionalization?
Authors: Pla-Barber José , Villar Cristina , Narula Rajneesh 
Published: June 2021

The disruption of the trade and investment activities of multinational enterprises as a consequence of the Covid-19 pandemic has reinvigorated the debate on the configuration of global value chains (GVCs) as well as the risks and challenges associated with offshoring. This article depicts how the pandemic might affect GVC configuration by driving a trend toward a more regional footprint in industries in which resilience and reliability are critical. Such a shift would create new opportunities for reshoring, and affect both the types of upgrading trajectories and the governance systems in value chains. The article also draws from the intersection of the global-strategy and value-chain fields to propose potential topics and avenues for further research related to these trends. JEL Classification: M16, M21, M14
‘Bonbibi’ Could Wait Till Our Boss Decides: Looking at the Changing Face of the Indian Sundarbans
Authors: Mukhopadhyay Prama 
Published: June 2021

Internal migration constitutes a major source of steady flow of population in India, and reports published by the World Economic Forum (WEF),1 2017 state that interstate migration in the country has doubled during 2001–2011, compared to the previous decade.2 In developing countries, such migration is often considered to be an effective way for income diversification for the economically marginalised sections of the society, even though its effect on ‘human development’ is oft debated. This article would engage with this debate and bring out how migration from the Indian part of the Sundarbans to other parts of the country is not only changing the demography of the region but is also having a strong impact on the local perception and attachment towards the deltaic landscape. By bringing in ethnographic details from a village in the Indian Sundarbans, which was predominately inhabited by the fishing community earlier, this article would bring out how traditional occupations like fishing are slowly losing their popularity in the face of the lure of out-migration, as the very identity of the ‘indigenous’ Sundarban fisher folks—who were once rightfully considered to be the true conservator of the forests—is changing. From there, this article would engage with the broader debate of rethinking whether migration can be considered as a positive indicator of development in such ecologically fragile areas like the Sundarban deltas, which used to indeed have a distinct economic, social and cultural life of its own.
Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells
Authors: Thoms Julie A. I. , Truong Peter , Subramanian Shruthi , Knezevic Kathy , Harvey Gregory , Huang Yizhou , Seneviratne Janith A. , Carter Daniel R. , Joshi Swapna , Skhinas Joanna , Chacon Diego , Shah Anushi , de Jong Ineke , Beck Dominik , Göttgens Berthold , Larsson Jonas , Wong Jason W. H. , Zanini Fabio , Pimanda John E. 
Published: June 2021

Abstract
Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These transitions are disrupted during leukemic transformation, but knowledge of the gene regulatory changes underpinning this process is elusive. We hypothesized that identifying core gene regulatory networks in healthy hematopoietic and leukemic cells could provide insights into network alterations that perturb cell state transitions. A heptad of transcription factors (LYL1, TAL1, LMO2, FLI1, ERG, GATA2, and RUNX1) bind key hematopoietic genes in human CD34+ hematopoietic stem and progenitor cells (HSPCs) and have prognostic significance in acute myeloid leukemia (AML). These factors also form a densely interconnected circuit by binding combinatorially at their own, and each other’s, regulatory elements. However, their mutual regulation during normal hematopoiesis and in AML cells, and how perturbation of their expression levels influences cell fate decisions remains unclear. In this study, we integrated bulk and single-cell data and found that the fully connected heptad circuit identified in healthy HSPCs persists, with only minor alterations in AML, and that chromatin accessibility at key heptad regulatory elements was predictive of cell identity in both healthy progenitors and leukemic cells. The heptad factors GATA2, TAL1, and ERG formed an integrated subcircuit that regulates stem cell-to-erythroid transition in both healthy and leukemic cells. Components of this triad could be manipulated to facilitate erythroid transition providing a proof of concept that such regulatory circuits can be harnessed to promote specific cell-type transitions and overcome dysregulated hematopoiesis.