bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell analysis of EphA clustering phenotypes to probe cancer cell
heterogeneity
Authors: Ravasio Andrea , Myaing Myint Zu , Chia Shumei , Arora Aditya , Sathe Aneesh , Cao Elaine Yiqun , Bertocchi Cristina , Sharma Ankur , Arasi Bakya , Chung Vin Yee , Green Adrianne C. , Tan Tuan Zea , Chen Zhongwen , Ong Hui Ting , Iyer N. Gopalakrishna , Huang Ruby YunJu , DasGupta Ramanuj , Groves Jay T. , Viasnoff Virgile 
Published: December 2021

Abstract
Eph receptors, a family of receptor tyrosine kinases, play a crutial role in
the assembly and maintenance of healthy tissues. Dysfunction in Eph signaling
are causally and correlatively associated with cancer progression. In breast
cancer cells, dysregulated Eph signaling has been largely linked to alterations
in receptor clustering abilities. In the present study, we implemented a
single-cell assay and a scoring scheme to systematically probe the spatial
organization of activated EphA receptor in carcinoma cells of different origin.
Using this assay, we found that cancer cells retained EphA clustering phenotype
upon cell division for several generations and degree of clustering reported for
population as well as single-cell migration potential. Finally, using
patient-derived cancer cell lines, we probed the evolution of EphA signalling in
cancer cell populations that underwent metastatic transformation and acquisition
of drug resistance. Taken together, our simple and scalable approach provides a
reliable quantitation of EphA associated gene expression and phenotypes in
multiple carcinomas and can assay the heterogeneity of cancer cell populations
in a cost- and time-effective manner.
Drivers of HIV-1 transmission: the Portuguese case
Authors: Pineda-Peña Andrea-Clemencia , Pingarilho Marta , Li Guangdi , Vrancken Bram , Libin Pieter , Gomes Perpetua , Camacho Ricardo Jorge , Theys Kristof , Abecasis Ana Barroso ,   on behalf of the
                    Portuguese HIV-1 Resistance Study Group
Published: December 2021

ABSTRACT

Background
Portugal has one of the most severe HIV-1 epidemic in Western Europe.
Two subtypes circulate in parallel since the beginning of the epidemic.
Comparing their transmission patterns and its association with transmitted
drug resistance (TDR) is important to pinpoint transmission hotspots and to
develop evidence-based treatment guidelines.

Methods
3599 HIV-1 naive patients collected between 2001 and 2014 were included
in the study. Sequences obtained from drug resistance testing were used for
subtyping, TDR determination and transmission clusters (TC)
analyses.

Results
Subtype B transmission was significantly associated with young males,
while subtype G was associated with older heterosexuals. Young males
infected with subtype B were more likely to be included in TC. Consistently,
a decreasing trend of prevalence and transmission of subtype G in Portuguese
originated people was observed. Active TCs were associated with subtype
B-infected males residing in Lisbon. TDR was significantly different when
comparing subtypes B (10.8% [9.5-12.2]) and G (7.6% [6.4-9.0])
(p=0.001).

Discussion
TC analyses shows that the subtype B epidemic is active and fueled by
young male patients residing in Lisbon and that transmission of subtype G in
Portugal is decreasing. Despite similar treatment rates for both subtypes in
Portugal, TDR is different between subtypes.
Stable encoding of visual cues in the mouse retrosplenial cortex
Authors: Powell Anna , Connelly William M. , Vasalauskaite Asta , Nelson Andrew , Vann Seralynne D. , Aggleton John , Sengpiel Frank , Ranson Adam 
Published: December 2021

Abstract
The rodent retrosplenial cortex functions as an integrative hub for sensory
and motor signals, serving roles in both navigation and memory. While
retrosplenial cortex (RSC) is reciprocally connected with the sensory cortex,
the form in which sensory information is represented in the retrosplenial cortex
and how it interacts with behavioural state is unclear. Here, we used 2-photon
cellular imaging of neural activity of putative excitatory (CaMKII expressing)
and inhibitory (parvalbumin expressing) neurons to measure visual and running
evoked activity in RSC and compare it to primary visual cortex (V1). We found
that stimulus position and orientation information was preserved between V1 and
RSC, and additionally that positional information was organised topographically.
Stimulus directional preference was biased towards nasal-temporal flow.
Locomotion modulation of activity of single neurons, both in darkness and light,
was also more pronounced in RSC than V1, and strongest in parvalbumin-positive
neurons. Longitudinal measurements of single neurons showed that these response
features were stably maintained over many weeks. These data provide evidence for
stable representations of visual cues in retrosplenial cortex which are highly
spatially selective. These may provide sensory data to contribute to the
formation of memories of spatial information.
Doing and undoing gender: women professionals' persistence in technology occupations
Authors: Saifuddin Samina M. , Dyke Lorraine , Hossain Md. Sajjad 
Published: December 2021

PurposeThis study aims to identify women professionals' strategies to persist in the male-dominated technology industry situated in the Bangladeshi socio-cultural context.Design/methodology/approachIn-depth interviews with women tech professionals were conducted to identify and explore the strategies. Thematic coding was used for data analysis.FindingsThe findings suggest that the complex interplay of macro-, meso- and micro-factors pushes women to defy societal and gender norms in their choice and persistence, yet they simultaneously conform to these norms. By simultaneous expressions of doing and undoing gender, these women dealt with hierarchies and inequalities, navigated masculinized industry and empowered themselves within a patriarchal culture. The strategies effectively allowed them to demonstrate agency and persist in tech occupations.Research limitations/implicationsThe study participants were women and recruited using snowball sampling. Future research could benefit from recruiting a larger, more varied sample using random sampling.Practical implicationsThe study can inform teaching and policy initiatives to increase women's representation in tech sectors through awareness campaigns, policy interventions and counseling.Originality/valueThe research extends the doing and undoing framework by integrating the relational perspective to explain women's agency and resilience situated in a patriarchal context. The paper focuses on women's micro-individual strategies to navigate macro- and meso-level forces. Moreover, Bangladesh is an under-researched context, and findings from the study can help design potential intervention strategies to increase women's participation.
Changes in sustainability in the global wine industry
Authors: Golicic Susan L. 
Published: December 2021

Purpose
The wine industry is the one that is tightly linked to sustainability as its processes both impact and are impacted by the environment, society and companies’ financial well-being. However, data show that this may not be recognized in practice. Thus, this research paper aims to examine what has changed with respect to sustainability practices over the past 10–15 years in this industry.

Design/methodology/approach
A development-based multi-method approach was used to examine the purpose. In Phase 1, a grounded theory study conducted between 2009 and 2015 from wine businesses in 12 different global regions brought to light a potential disconnect between theory and practice in the importance of sustainability. In Phase 2, a comprehensive literature review and analysis of updated online content from the Phase 1 companies was conducted to paint a picture of the progression of sustainability focus and its implementation in company processes.

Findings
Using legitimacy theory as a foundation, it was found that the choice to pursue sustainability in this industry generally begins with a focus on environmental practices followed by financial sustainability and more recently social sustainability. Producers are also starting to emphasize overall sustainability often encompassing all three dimensions. The industry has also progressed through “levels of sophistication” in the different major supply chain processes (supply, production and distribution) over the years with their environmental efforts.

Originality/value
A framework of sustainability growth in the industry through a matrix of process sophistication is developed from the data. The results offer implications for theory, practice and industry policy and informs the future trajectory of sustainability within global business.
Linking supply network flexibility with mass customization capability
Authors: Ullah Inayat , Narain Rakesh 
Published: December 2021

Purpose
The importance of supply network flexibility (SNF) in the development of mass customization capability (MCC) has been implied in the literature but seldom subjected to empirical investigation. To fill the gap and contribute to MC literature, this paper aims to examine the role of SNF in facilitating the development of MCC of organizations. Furthermore, it has been investigated whether the use of information and communication technologies (ICTs) strengthens the above relationship.

Design/methodology/approach
Drawing on the supply chain literature and dynamic capability theory, the study proposes a research framework depicting the interconnectedness among the variables of interest. The proposed framework has been tested using structural equation modelling based on partial least squares by using the data collected from a questionnaire-based survey of a sample of Indian manufacturing organizations.

Findings
The findings indicate that the dimensions of SNF, namely, sourcing flexibility and supplier flexibility, positively affect the MCC of the organizations and the strength of these relationships is further amplified by the implementation of ICTs.

Practical implications
The study shows the managerial opportunities for the development of a flexible and competent supply network to facilitate the development or enhancement of MCC.

Originality/value
This study contributes to scant literature by providing empirical evidence for the relationship between SNF and MCC. Further, this study enriches the understanding of the crucial role of ICT by exploring its moderating effect on the relationship between the variables of interest.
Residents perception of crime characteristic and its causation across residential densities in Mushin, Lagos Nigeria
Authors: Agbabiaka Hafeez Idowu , Daramola Oluwole Philip , Adesanya Abiola Aminat 
Published: December 2021

Purpose
The purpose of this study is to examine crime characteristics and its causation in Mushin Lagos Nigeria. The incidence of urban crime in Nigeria has been associated with increasing urbanization, high poverty level, congestion, unemployment, deprivation, income inequality, poor physical planning and design, political democratization, disorganization and moral decadence and breakdown in infrastructure. Hence, tackling urban crimes in selected communities within Lagos state will address several issues, creating inclusiveness and safer communities.

Design/methodology/approach
Primary data were collected through questionnaire administration on three income groups, cutting across 14 communities in the study area. Multistage sampling techniques were adopted to select six communities (Idi Araba, Idi Oro, Fadeyi, Ilasamaja Papa Ajao and Ilupeju), 60 streets and 144 respondents for this study. Respondents selected for this study are individuals who have stayed in the communities for more than five years.

Findings
This study reports no statistically significant variation in the crime occurrence by type across the selected communities. However, residents experienced a high occurrence of crime against a person in robbery, assault and pocket-picking, especially among the low-income earners. The same trend was observed in crimes against property such as theft, burglary and store breaking in the low- and middle-income areas, whereas burglary, theft and car theft have high occurrence in the high-income areas. In addition, crimes against morality inform of gambling, prostitution and offences against public peace were high in the low- and high-income areas, whereas gambling, prostitution and bribery are common in the middle-income areas.

Practical implications
This study identifies appropriate policies for combating crime. Collective values promote citizen participation and encourage Do It Yourself in the communities. Stakeholders’ crime prevention mechanism will create safer communities. Social crime prevention and environmental design is an instrument for creating safer cities.

Originality/value
The outcome of this study addresses goal 11 of the SDGs if properly managed.
When does presenteeism harm productivity the most? Employee motives as a key moderator of the presenteeism–productivity relationship
Authors: Henderson Alexandra A. , Smith Claire E. 
Published: December 2021

PurposeWhile presenteeism is empirically linked to lower productivity, the role of a person's motives for engaging in presenteeism has been overlooked. Using a Conservation of Resources Theory framework, we examine the moderating effects of presenteeism motives (approach and avoidance motives) on the presenteeism–productivity relationship.Design/methodology/approachA sample of 327 dental hygienists with chronic health conditions was surveyed. Moderated multiple regression was used to test study hypotheses.FindingsResults indicate that presenteeism does indeed appear to detriment productivity. However, we demonstrate that motives are an important moderator, such that high approach motives appear to mitigate the negative effects of presenteeism on productivity.Practical implicationsBased on our findings, we suggest managers strive to improve the approach motives of their employees through processes such as job enrichment.Originality/valueThis study demonstrates that presenteeism is not always detrimental to productivity, as approach motives appear to mitigate the negative effects of presenteeism on productivity. These results could drive future research on presenteeism, as well as inform best practices related to managing workers with chronic health issues.
Digital servitization strategies for SME internationalization: the interplay between digital service maturity and ecosystem involvement
Authors: Kolagar Milad , Reim Wiebke , Parida Vinit , Sjödin David 
Published: December 2021

PurposeThe purpose of this study is to understand how digital servitization enables the process of internationalization for industrial SMEs.Design/methodology/approachThe present study has adopted an exploratory multiple case study, conducting a total of 40 interviews in a two-phased approach to data collection. The first phase consisted of exploratory interviews with twenty-six industrial SMEs connected to the manufacturing industry in Sweden and Finland. Then, six SMEs were selected in the second phase to participate in additional in-depth interviews.FindingsFirst, this study identifies three gradual enabling phases concerned with the digital service maturity of SMEs consisting of digital awareness, digital service innovation and digital service mass customization. Second, the three interdependent phases of ecosystem knowledge synergy, ecosystem integration and ecosystem value co-creation were identified to improve ecosystem involvement. Finally, a process framework has been developed for SME internationalization consisting of a digital servitization innovation strategy, a digital servitization ecosystem strategy and a digital servitization scaling strategy.Originality/valueThe present research contributes to how digital servitization enables SME internationalization by demonstrating how the development of digital service offerings and ecosystem partnerships supports the internationalization process. This research extends the literature by proposing a process framework for the digital-servitization-enabled internationalization of SMEs. This process perspective provides a richer explanation of the complex interplay between servitization, digitalization and ecosystems choices, which supports the expansion into international markets.
Patterns of business model innovation for advancing IoT platforms
Authors: Markfort Lino , Arzt Alexander , Kögler Philipp , Jung Sven , Gebauer Heiko , Haugk Sebastian , Leyh Christian , Wortmann Felix 
Published: December 2021

PurposeThe emergence of Internet of Things (IoT) platforms in product companies opens up new data-driven business opportunities. This paper looks at the emergence of these IoT platforms from a business-model perspective.Design/methodology/approachThe study applies a mixed method with two research studies: Study I–a cluster analysis based on a quantitative survey, and Study II–case studies based on qualitative interviews.FindingsThe findings reveal that there is no gradual shift in a company's business model, but in fact three distinct and sequential patterns of business model innovations: (1) platform skimming, (2) platform revenue generation and (3) platform orchestration.Research limitations/implicationsThe results are subject to the typical limitations of both quantitative and qualitative studies.Practical implicationsThe results provide guidance to managers on how to modify the components of the business model (value proposition, value creation and/or delivery and profit equation) in order to enable platforms to advance.Social implicationsAs IoT platforms continue to advance, product companies achieve better performance in terms of productivity and profitability, and more easily secure competitive advantages and jobs.Originality/valueThe paper makes three original contributions: (1) it is the first quantitative study on IoT platforms in product companies, (2) identifies three patterns of business model innovations and (3) offers a first process perspective for understanding the sequence of these patterns as IoT platforms advance.
A knowledge-intensity-based collaborative community governing mechanism for inter-organisational HR collaborations
Authors: Koster Ferry 
Published: December 2021

PurposeStudies of inter-organisational relationships have mainly investigated collaborations in the technical domain. There is considerably less research conducted in the field of inter-organisational collaborations in the domain of human resource management (HRM). At the same time, it is acknowledged that inter-organisational collaboration in this domain is relevant for organisations. By focusing on inter-organisational HR collaborations, this study provides insights into how these collaborations are governed, as well as how the mode of governance is explained.Design/methodology/approachThe paper relies on a quantitative study among 161 Dutch companies that collaborate with each other on HR-related issues. A measure of governance of inter-organisational HR collaboration is developed and applied.FindingsOrganisations tend to apply a mixture of governance mechanisms to govern their inter-organisational HR collaborations. Hence, they apply a collaborative community type of governance to these HR collaborations. The analyses show that the level of knowledge intensity, in particular the extent to which the organisation applies organisational learning practices, explains the use of collaborative community.Originality/valueFirst, this study focuses on an under-researched field: inter-organisational HR collaborations. Secondly, the study extends existing insights into the governance of inter-organisational relationships by analysing a novel data set.
Recovery college features and context: advancing a recovery and well-being policy agenda
Authors: Woolsey Amadene , Mulvale Gillian 
Published: December 2021

Purpose
Internationally, there has been a move towards more recovery-oriented mental health policies for people living with mental illness, and some countries have included well-being as a population-level objective. In practice, these policy objectives can be difficult to achieve because of deeply rooted policy legacies, including a biomedical approach to care and the stigma associated with mental illness. The purpose of this paper is to investigate how interventions that operate outside the formal mental health system, such as recovery colleges (RCs), may advance these policy objectives more easily than efforts at broader system reform.

Design/methodology/approach
This study conducted a scoping review to explore the features and context of RCs that make the model an attractive and feasible opportunity to advance a recovery and well-being agenda. Our research is motivated by the initial and growing adoption of RCs by the Canadian Mental Health Association. This paper applies the consolidated framework for implementation research to analyse features of the model and the context of its implementation in Canada.

Findings
The RC’s educational approach, adaptability, coproduced nature and positioning outside the formal mental health system are key features that facilitate implementation without disrupting deeply entrenched policy legacies. Other facilitators in the Canadian context include the implementing organisation’s independence from government, its federated structure and the model’s alignment with national policy objectives.

Originality/value
This paper highlights how interventions outside the formal mental healthcare system can promote stated recovery and well-being policy goals.
Risk factors for depression in older adults in Bogotá, Colombia
Authors: Salazar Ana María , Reyes María Fernanda , Gómez María Paula , Pedraza Olga , Lozano Angela Gisselle , Montalvo María Camila , Rodriguez Fandiño Juan Camilo 
Published: December 2021

Purpose
This paper aims to identify psychosocial, demographic and health risk factors associated with depression in older people.

Design/methodology/approach
A correlational study with 281 independent and autonomous persons of the community over 60 years old from Bogotá was conducted. The three instruments used to measure the variables included in the data analyses were Demographic and Health Data Questionnaire, Short version of 15 items of Geriatric Depression Scale (GDS) and Montreal Cognitive Assessment Test (MoCA).

Findings
Fifteen percent of the participants presented depression. Depression was associated with different demographic, low social support and health factors in this population group and was particularly high in women. Being a woman with poor social support networks and a previous history of depressive episodes should be considered as determining factors within a clinical risk profile for depression in older adulthood. It is essential to design prevention strategies focused on women and on the development of better social support in old age.

Originality/value
Depression is a prevalent and highly disabling disease, when it is suffered by an older person it is associated with higher mortality, functional dependence, poor physical health, worse quality of life indicators and psychological well-being. In the elderly, the clinical diagnosis of depression is difficult, as it has a high comorbidity and is often confused with other health conditions prevalent during older adulthood.