bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid RSO Algorithm with SFLA for Scientific Workflow Scheduling in Cloud Using Clustering Techniques
Authors: M KARPAGAM 
Published: November 2021

Abstract
An inevitable part of the cloud computing environment is virtualization, as it can multiplex or combine many virtual machines in a single physical machine, and simultaneously an isolated environment is provided to every virtual machine. An important issue in cloud computing is workflow scheduling, which maps tasks of workflow to VMs based on various functional and non-functional requisites. Workflow scheduling is an NP-hard optimization problem and it is quite hard to achieve an optimal schedule. Metaheuristic algorithms helped in solving the problem of cloud task scheduling and this was compared to other heuristics. Reactive Search (RSO) and its structure will consist of a local heuristic based on a certain neighborhood complemented by making use of a memory-based mechanism. The Shuffled Frog Leaping Algorithm (SFLA) is based on swarm evolution that imitates information exchange divided into memeplexes when searching for food. This paper proposes a new set of optimization heuristics along with hybrid optimizations (RSO - SFLA) to solve problems in combinatorial optimization.
Medical Student Perspectives on Substance Misuse Education in the Medical Undergraduate Programme: A Grounded Theory Approach
Authors: Rudrakumar Senthan , Taylor David 
Published: November 2021

Abstract
BackgroundA substance misuse epidemic has been appropriately responded to in medical education. Numerous curriculum reviews and most recently a UK department of Health (DOH) project have identified deficiencies in substance misuse education whilst also suggesting an alternative curriculum to be implemented into UK medical school. The student perspective has largely been muted during this process and this study aims to explore this using a constructivist grounded theory approach.Methods Eleven Final year and intercalating medical students across three separate focus groups participated in this study. Focus groups were initially less structured with subsequent focus groups session using more guided questions. Audio recordings of focus groups were transcribed into codes and categories until data saturation was obtained. Results Medical students had a common consensus that substance misuse education was an underperforming subject in their curriculum, from limited teaching hours to curriculum design and organisational problems. Students identified an alternative curriculum is required to not only prepare students for their future clinical duties but also their own personal lives. Students highlighted this proximity to a ‘dangerous world’ where exposure to substance misuse risks were faced daily. This exposure also provided a source of informal learning experiences which students deemed as being potentially unbalanced and even dangerous. Students also identified unique barriers to curriculum change with reference to a lack of openness due to the impacts of disclosure in substance misuse. Conclusion The student perspective identifies deficiencies in substance misuse education and provides alternative curriculum approaches like that discussed in current curriculum reviews and projects. The student perspective however provides a unique look at how substance misuse pervades into their own lives and how informal learning is a largely underestimated source of learning with more dangers than benefits. This together with the identification of unique barriers to curriculum change and substance misuse being a ubiquitous problem, medical faculties should work together with students themselves to drive curriculum change forward at a local level.
A Controlled Material Flow Forming Mechanism of Curve Cutter Forging in The Hot Impression Forging of The Medical Instrument
Authors: Fuh Yiin-Kuen , Chen Chi-Peng , Wu Wei-Li , Ho Ming-Shiou , Tzeng Ching-Shiang 
Published: November 2021

Abstract
In this study, a forming process during producing medical surgery curve cutter stapler would be tentatively as well as numerically investigated and validated by the simulations. The reasons for the investigation are to find the critical technology of the forming process and to understand this medical tool head forming within the forming process associated with medical surgery curve cutter stapler and improve the traditionally forming process. Moreover, to understand the medical tool head forming, the novel forging process, and the parting line approach are offered and simulated by the FE software QForm, the method data on the medical tool head forging are investigated and compared with the experimental analysis. According to the outcomes of the simulations, the distributions of the forming process, some parameters have been gotten to explain and improve these microscopic phenomena. The precision of the numerical patterns has been confirmed by comparing them with the test dimensions. The offered revised model from the forming preform has been submitted to achieve an alike forging condition when reducing manufacturing cost After the improved method, measure the shrinkage width of the workpiece. Compared with the product of the traditional process, the widest area is 6.37mm shrink to 6.29mm. The shrinkage is about 1%. Compared with the previous result is 5%, the improvement plan has been optimized the outcomes very much.
Physical Activity Improves Outcomes of Combined Lenvatinib Plus Anti-PD-1 Therapy In Patients With Unresectable Hepatocellular Carcinoma
Authors: Liu Xue-Feng , Zhu Xiao-Dong , Feng Long-Hai , Li Xiao-Long , Xu Bin , Li Kang-Shuai , Xiao Nan , Lei Ming , Sun Hui-Chuan , Tang Zhao-You 
Published: November 2021

Abstract
Background: Adaptive resistance is one of the major hinderances for unresectable hepatocellular carcinoma (HCC) treated with lenvatinib and anti-programmed cell death protein 1 (anti-PD-1) therapy. Physical activity is known to have anti-cancer effects, including immunomodulatory actions, influencing patients’ outcomes. This study investigated the hypothesis that physical activity synergizes with combined lenvatinib plus anti-PD-1 therapy to enhance efficacy in patients with unresectable HCC.Methods: The physical activity levels of patients with unresectable HCC treated with combination therapy using lenvatinib plus anti-PD-1 antibodies were recorded by questionnaire. Patients were categorized according to physical activity levels (active vs. sedentary). The primary outcome was overall survival (OS), analyzed using the Kaplan-Meier method with a log-rank test. Secondary outcomes included objective response rate (ORR) and progression-free survival (PFS). Factors associated with survival and ORR were analyzed using regression analyses. A subcutaneous syngeneic HCC model was generated in C57BL/6 mice. Mice were randomized to receive placebo, combined lenvatinib plus anti-PD-1 antibodies or combination therapy plus physical activity. Tumors were measured every 3 days and harvested for immunohistochemistry analysis at 20 mm maximum diameter. Results: Fifty-nine patients with unresectable HCC were categorized to active (n=28) or sedentary (n=31) groups. The active group had higher albumin and des-γ-carboxy prothrombin levels and lower hepatitis B virus load at baseline; other clinical and oncologic characteristics were comparable between the two groups. Patients in the active group had significantly longer OS (HR = 0.220, 95% CI, 0.060-0.799) and PFS (HR = 0.158, 95% CI, 0.044-0.562) and higher ORR (OR = 4.571, 95% CI, 1.482-14.102) than patients in the sedentary group. Regular physical activity was independently associated with OS, PFS and ORR. The mouse model showed that physical activity significantly suppressed tumor growth and prolonged survival of tumor-bearing mice. Furthermore, physical activity inhibited Treg cell infiltration and immune checkpoint expression (including CTLA4, TIGIT and TIM3) induced by long-term combined lenvatinib plus anti-PD-1 therapy, improving efficacy. Conclusions: Regular physical activity was associated with improved outcomes in patients receiving combined lenvatinib plus anti-PD-1 therapy for unresectable HCC. Physical activity may improve therapeutic efficacy by reprograming the tumor microenvironment from an immunosuppressive to immunostimulatory phenotype.
A method based on circumferential strain distribution for roller path design in conventional spinning of thin-walled conical part with curved surface
Authors: Wang Yongdi , Li Hongwei , Gao Pengfei , Zhan Mei , Yan Xinggang , Niu Haotong 
Published: November 2021

Abstract
Multi-pass conventional spinning is the preferable forming technology for the forming of thin-walled conical part with curved surface (TCPCS) in aerospace field. In multi-pass conventional spinning, the design of roller path is a critical problem due to its sensitive effect on the deformation mode and forming defect during spinning process. However, at present, the roller path is still mainly designed based on experience and trial-and-error, which seriously restricts the high-performance spinning of TCPCS. In this work, a new quantitative method based on circumferential strain distribution was developed for the roller path design in multi-pass conventional spinning of TCPCS. In this method, the total required circumferential strain for the forming of final TCPCS by conventional spinning was firstly determined. Then, the spinning passes number were obtained through dividing the total required circumferential strain by the ultimate circumferential strain producing the spinning instability ( ε θult ). As for the roller path profile in each pass, it is divided into two sections and determined respectively, i.e. the attaching mandrel section and the performing section. The attaching mandrel section presents the same profile of mandrel. The profile of preforming section is determined point-by-point by distributing the rest of circumferential strain { ε θni } to produce the final TCPCS. The point-by-point distributed circumferential strain is half of the { ε θni } at the initial stage until reaches the half of ε θult , then it will keep the half of ε θult to the end. The proposed new method of roller path design was validated by finite element simulation, where well spinning stability, wall thickness distribution and roundness were obtained. This method provides a quantitative, high-efficient and universal way for the roller path design in conventional spinning of TCPCS.
Mapping evidence of Universal Health Coverage in the world: a protocol for a scoping review
Authors: Endalamaw Aklilu , Gilks Charles F , Ambaw Fentie , Assefa Yibeltal 
Published: November 2021

Abstract
Background
Universal health coverage (UHC) is critical for improving global health and socioeconomic development. Monitoring and evaluating UHC's progress has also been suggested as an additional intervention to improve its road map. Globally, the concept of UHC is being desperately used by health care delivery systems and research institutions using a variety of indicators. More evidence is required to know what is known and the gaps are in the UHC literature that helps to identify research problems. The review will map the available researches of UHC from around the world.
Methods
The scoping review will be reported using the checklist The Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR). For studies reporting data on UHC and its dimensions, systematic searches will be conducted in PubMed, Scopus, Web of Science, Google Scholar, and the United Nations, World Health Organization, and World Bank repositories. To present the review findings, a narrative synthesis will be performed.
Discussion
UHC is a cornerstone to achieve the health goal of UN’s by the end of 2030. The mapping of available literature towards UHC will provide evidence that will help in the designing and implementation of health policy, health research and health care services.
Conclusions
A protocol for a global scoping review of UHC research is described. This scoping review will add to the body of knowledge about UHC research. The review will identify UHC research questions for which primary research or a systematic review and meta-analysis will be conducted. This is the first review of UHC to be conducted. This review will prioritize UHC research questions in relation to the sustainable development goals.
Pronounced Enhancement in Radiosensitization of Esophagus Cancer Cultivated in Docosahexaenoic Acid Via The PPAR-γ Activation
Authors: Yang Ying , Xu Ying , Zhao Congzhao , Zhang Lirong , Nuerbol Aslibek , Wang Lili , Jiao Yang 
Published: November 2021

Abstract
Background: Docosahexaenoic acid (DHA) has been reported to slow the tumor growth and improve prognosis, and been used to co-operate with many other chemotherapy medicines. Up to now, survey focuses on the interaction between DHA and radiation is relatively modest. Our study sought to evaluate the changes of radiosensitivity caused by DHA on esophageal cancer cells. Besides, potential mechanism and molecular are needed to be explored.Results：DHA enhanced proliferation inhibition of irradiation on esophageal cancer cells. DNA damage, especially double-strand break, induced by irradiation, was sharply increased by DHA addition. DHA accelerated G2/M phase blocking, cell apoptosis and lipid peroxidation after radiotherapy. The similar outcomings were observed in mouse xenograft tumor experiment that the malignancy substantially dismissed after the combined treatment of DHA and irradiation. Moreover, PPAR -γ was verified to increase post-treatment. Suppression of PPAR -γ would attenuate the radio sensitization triggered by DHA incompletely.Conclusion：DHA could improve radio sensitivity in esophageal squamous cancer cells in vivo and in vitro by activating PPAR -γ. Due to its explicitly usage and convenient, DHA and other PPAR -γ agonists would serve as an adjuvant therapy before radiotherapy if the clinical trials indicated positive from now on.
The Synergistic Effect of The Preceding Winter Northern Hemisphere Annular Mode and Spring Tropical North Atlantic SST On Spring Extreme Cold Events in The Mid-high Latitudes of East Asia
Authors: Wang Hao , Zheng Fei , Diao Yina , Li Jianping , Tang Xinxin , Sun Yue , Li Fei , Zhang Yazhou 
Published: November 2021

Abstract
In this paper, the synergistic effect of the preceding winter positive Northern Hemisphere annular mode (pNAM) and spring negative tropical North Atlantic (nTNA) sea surface temperature anomaly (SSTA) on spring extreme cold events in the mid-high latitudes of East Asia (MHEA) is investigated. The results show that the co-occurrence of the two factors is unfavorable for extreme cold events during spring in the MHEA via the snow cover and atmospheric bridges. Over the Atlantic, the spring nTNA SSTA can lead to an atmospheric response that is similar to the North Atlantic Oscillation (NAO), which enhances the persistence of the pNAM and in turn amplifies the negative spring Eurasian snow cover extent (EASCE) anomaly caused by the preceding winter pNAM. Meanwhile, the spring EASCE is closely related to the spring MHEA anomalous anticyclone. In addition to storing its signal in the spring EASCE, the spring nTNA SSTA can also lead to the spring MHEA anomalous anticyclone via the eastward Rossby wave train. The evidence shows that the Rossby wave energy can propagate eastward to the MHEA as a result of the enhanced negative spring EASCE anomaly and Rossby wave induced by the spring nTNA SSTA, and the two factors have an obvious synergistic effect on the spring MHEA anomalous anticyclone. This anomalous MHEA anticyclone becomes a barrier that can hinder the intrusion of cold air from the polar region and can increase the thickness of the atmospheric layer. The anomalous sinking motion of the spring MHEA anomalous anticyclone can also lead to an increase in net radiation received at the surface and increase the air temperature through the vertical motion of air. The southerly wind over the west side of the spring MHEA anomalous anticyclone leads to horizontal warm advection. All of the above processes favor an increase in air temperature and dampen extreme cold events, implying the synergistic effect of the preceding winter pNAM and spring nTNA SSTA on spring extreme cold events in the MHEA.
Did More Generous Health Insurance Improve Health Outcomes of The Elderly? Evidence From China
Authors: Shieh Jusheng , Xu Xinpeng , You Hua , Wu Qifeng 
Published: November 2021

Abstract
Background: Catastrophic Medical Insurance (CMI) has been piloted in China Since 2012 and gradually implemented in various regions. Most studies focus on its impact on medical economic risks, and few studies discussed the impact of CMI on health of the elderly.Methods: This study used Chinese Longitudinal Healthy Longevity Survey (CLHLS) data to explore the impact of CMI on health of the elderly. Difference-in-differences (DID) and Propensity score matching-DID were employed to study the health impact of CMI. Heckman selection model was used to study the potential mechanisms.Results: We found that the implementation of CMI improved the mental health of the elderly, and the effect was limited. Moreover, the positive effect of CMI on the health of the elderly was mainly in the high-income group, and CMI had no significant effect on any health indicators of the low-income group population. The potential channel of CMI health improvement was its ability to increase hospitalization rate in the elderly. Conclusions: Therefore, the health promotion and equity of CMI deserve more attention, and the compensation level of CMI needs to be improved under the premise of sustainable and effective supervision of the fund.
Fusobacterium Nucleatum Promotes the Development of Acute Liver Failure by Inhibiting the NAD+ Salvage Metabolic Pathway
Authors: Cao Pan , Chen Qian , Shi Chunxia , Wang Luwen , Gong Zuojiong 
Published: November 2021

Abstract
Background: Acute liver failure (ALF) patients are often accompanied by severe energy metabolism abnormalities and intestinal microecological imbalance. The intestinal mucosal barrier is severely damaged. Intestinal endotoxin can induce intestinal endotoxemia through the "Gut-Liver axis". More and more evidence shows that members of the gut microbiota, especially Fusobacterium nucleatum (F. nucleatum), are related to inflammatory bowel disease, but whether F. nucleatum is involved in the development of ALF and whether it affects the liver energy metabolism is unclear. Methods: This study first detected the abundance of F. nucleatum and its effect on ALF disease, and explored whether F. nucleatum aggravated liver inflammation in vitro and in vivo. Results: Our data showed that liver tissues of ALF patients contained different abundances of F. nucleatum, which were related to the degree of liver inflammation. In addition, we found that F. nucleatum infection affected the energy metabolism of the liver during the development of ALF, inhibited the synthesis pathway of nicotinamide adenine dinucleotide (NAD+)'s salvage metabolism, and promoted inflammatory damage in the liver. In terms of mechanism, F. nucleatum inhibited NAD+ and the NAD+-dependent SIRT1/AMPK signaling pathway, and promoted liver damage of ALF. Conclusions: F. nucleatum coordinates a molecular network including NAD+ and SIRT1 to control the progress of ALF. Detection and targeting of F. nucleatum and its related pathways may provide valuable insights for the treatment of ALF.
Influence of cultural factors on choice of childbirth place among women in Oyigbo L.G.A. Rivers State, Nigeria
Authors: OBIKA-NDIRI NGOZI AFULENU , NDIKOM CHIZOMA MILLICENT , OBIKA OGOCHUKWU IMMACULATE , ASEMINASO OMINEOKUMA TUBONEMI 
Published: November 2021

Abstract
BACKGROUND: Choices of childbirth places among women may influence the risk rate of both maternal and newborn health and some cultural practices which encourages both maternal mortality and infant death, are still a major challenge especially in developing countries like Nigeria, cultural norms and practices during childbirth are common but little is documented about how these cultural beliefs and their influence on the women of child bearing age and their childbirth place choices. The aim of this study was to find out the prevalent cultural factors that influence the choice of childbirth places among the women of child bearing age, in Oyigbo Local Government area of Rivers State in Nigeria.METHODOLOGY: A self-structured questionnaire was used as instrument to collect data for the study through simple random sampling, and these data was analyzed using Frequency and percentage for descriptive statistics while chi-square was used for inferential statistics at 0.05 level of significance. RESULT: The result showed that mean age of the women is 35.27 and most of them had secondary education, also there was a high level of hospital/health facility adherence among the women in Oyigbo Local Government Area of Rivers and also there was no significant association between cultural factors and choices of childbirth places among the women.CONCLUSION: Therefore, this study has shown that there is no significant cultural influence on the choices of childbirth places of women in Oyigbo Local Government Area of Rivers State.
Epidemiological Characteristics of COVID-19 Deaths In China: An Analysis of Environmental Factors
Authors: Feng Xixi , Du Peipei , Li Guobao , Cao Peihua , Luo Jiaohua , Yan Xiaodong , Luo Jiawei , He Daihai , Yang Lin , Wang Xiaohui , Yang Shu , Fu Yang , Chen Yaolong 
Published: November 2021

Abstract
Background: As of April 2020, most of the confirmed cases outside Hubei province have been cured or confirmed dead in China. We aimed to understand environmental factors leading to COVID-19-related mortality in non-Hubei region.Methods: We collected spatial-temporal and environmental data of 99 cases of COVID-19-related deaths outside of Hubei province in Mainland China between January 22, 2020 and April 6, 2020. A descriptive analysis, including a spatial-temporal distribution of daily reported diagnosed cases and related deaths, was conducted. We analyzed the possible environmental factors that affect the provincial-level case fatality rate (CFR) of COVID-19 outside Hubei, China.Results: Among the 99 reported deaths, 59 (59.6%) were male and 40 (40.4%) were female. The mean age at death was 71.30 (SD 12.98) years and 74 deaths were among those 65 years or older. The CFR was negatively correlated with temperature (r=-0.679, P<0.001) and humidity (r=-0.607, P=0.002), while latitude was positively correlated with the CFR (r=0.636, P=0.001). There were no statistically significant associations between CFR and the social environment factors.Conclusion: Higher CFR of COVID-19 was associated with lower temperature, lower humidity, and higher latitude. Continual analysis of daily reported diagnoses and mortality data can help healthcare professionals and policy makers understand the trends within a country in order to better prepare nationwide prevention and care guidelines, along with adequately appropriate funds accordingly.