bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latency to delivery in physical examination‐indicated cerclage in twins is similar to that in singleton pregnancies
Authors: Ponce Júlia , Benítez Leticia , Baños Núria , Goncé Anna , Bennasar Mar , Muñoz Míriam , Cobo Teresa , Palacio Montse 
Published: December 2021

AbstractObjectiveTo compare latency to delivery and perinatal outcomes between twin and singleton pregnancies undergoing physical examination‐indicated cerclage.MethodsRetrospective observational study (2007–2017) of women who underwent physical examination‐indicated cerclage at the Hospital Clinic of Barcelona. Primary outcomes were latency from cerclage to delivery and gestational age at delivery. Secondary outcomes included: neonatal morbidity and mortality, preterm prelabor rupture of membranes, clinical chorioamnionitis and cerclage displacement. Wilcoxon‐test and χ2 test were used to compare continuous and categorical variables.ResultsSixty women were included (17 twins and 43 singletons). There were no differences in gestational age at cerclage or presence of bulging membranes between groups. Median (25th;75th percentile) gestational age at delivery was 27.1 (24.5;32.3) weeks in the twin group and 27.6 (25.3;35.3) weeks in the singleton group (P = 0.594). There were no statistically significant differences in latency from cervical cerclage to delivery between the two groups (43 days [21;64] vs. 29 days [16;76], respectively; P = 0.938). There were no differences in neonatal mortality (2/26 [7.7%] vs. 1/33 [3.1%]; P = 0.578) or in composite neonatal morbidity (14 [53.9%] vs. 14 [42.4%]; P = 0.283) between groups, respectively.ConclusionThese results suggest that physical examination‐indicated cerclage placement in twins could prolong latency to delivery similarly to singleton pregnancies.
Build a Better Book: Enriched Literacy‐Project‐Based Learning for Multilingual Students
Authors: Walsh Benjamin , Dalton Bridget 
Published: December 2021

AbstractThis curriculum case study describes the design and enactment of the Build a Better Book project with a group of Spanish‐English bilingual high school students. Within an enriched literacy project‐based learning instructional approach, students collaborated to design and fabricate multimodal 3D printed tactile picture books for children who are blind or have visual impairment. We draw on project examples to present design principles and practices that teachers may flexibly adapt to build purposeful and rigorous project‐based curriculum that will support students in making personal connections to their learning, and is responsive to the strengths and needs that multilingual students bring to school.
Long non‐coding RNA HAGLROS promotes the development of diffuse large B‐cell lymphoma via suppressing miR‐100
Authors: Shu Ling , Guo Kun , Lin Zeng‐Hua , Liu Hong 
Published: December 2021

AbstractBackgroundLong non‐coding RNAs (lncRNAs), a vital component of functional regulators, are involved in various human cancers development, including diffuse large B‐cell lymphoma (DLBCL). In particular, lncRNA HAGLROS has been reported to be associated with several types of cancer in humans. Nevertheless, the role of HAGLROS in DLBCL has yet to be described.MethodsThe HAGLROS expression patterns and its relationship with clinicopathological features and survival were investigated in DLBCL patients. CCK‐8 and transwell assays were used to analyze the cell proliferation, migration, and invasion capacities. AGO2‐RIP, dual‐luciferase assay, RT‐qPCR, and rescue experiments were fulfilled to measure the physical interaction between HAGLROS and miR‐100. Xenograft assay was conducted to test tumor growth ability.ResultsHAGLROS was upregulated in DLBCL tissues and cells, and closely associated with advanced clinicopathological features. Upregulation of HAGLROS resulted in poor survival outcomes in DLBCL patients. In addition, HAGLROS knockdown inhibited the proliferation, migration, and invasion of DLBCL cells in vitro. Further experiments revealed that HAGLROS negatively regulated the expression of miR‐100 in DLBCL, and the expression of miR‐100 and HAGLROS showed an inverse correlation in DLBCL tissues. HAGLROS functioned as a competing endogenous RNA for miR‐100 in DLBCL cells, and miR‐100 overexpression abolished the oncogenic effects of HAGLROS upregulation on DLBCL progression. Besides, in‐vivo assays revealed that HAGLROS knockdown suppressed tumor growth in nude mice.ConclusionHAGLROS overexpression contributes to DLBCL development and poor prognosis via targeting miR‐100, which could be a potential prognostic biomarker and therapeutic target for DLBCL patients.
Comparative effectiveness of ciltacabtagene autoleucel in CARTITUDE‐1 versus physician's choice of therapy in the Flatiron Health multiple myeloma cohort registry for the treatment of patients with relapsed or refractory multiple myeloma
Authors: Martin Thomas , Krishnan Amrita , Yong Kwee , Weisel Katja , Mehra Maneesha , Nair Sandhya , Qi Keqin , Londhe Anil , Diels Joris , Crivera Concetta , Jackson Carolyn C. , Olyslager Yunsi , Vogel Martin , Schecter Jordan M. , Banerjee Arnob , Valluri Satish , Usmani Saad Z. , Berdeja Jesus G. , Jagannath Sundar 
Published: December 2021

AbstractIntroductionCiltacabtagene autoleucel (cilta‐cel) is a novel chimeric antigen receptor T‐cell therapy that is being evaluated in the CARTITUDE‐1 trial (NCT03548207) in patients with relapsed or refractory multiple myeloma (RRMM) who received as part of their previous therapy an immunomodulatory drug, proteasome inhibitor, and an anti‐CD38 monoclonal antibody (i.e., triple‐class exposed). Given the absence of a control arm in CARTITUDE‐1, this study assessed the comparative effectiveness of cilta‐cel and physician's choice of treatment (PCT) using an external real‐world control arm from the Flatiron Health multiple myeloma cohort registry.MethodsGiven the availability of individual patient data for cilta‐cel from CARTITUDE‐1 and PCT in Flatiron, inverse probability of treatment weighting was used to adjust for unbalanced baseline covariates of prognostic significance: refractory status, cytogenetic profile, International Staging System stage, time to progression on last regimen, number of prior lines of therapy, years since diagnosis, and age. Comparative effectiveness was estimated for progression‐free survival (PFS), time to next treatment (TTNT), and overall survival (OS). A range of sensitivity analyses were conducted.ResultsBaseline characteristics were similar between the two cohorts after propensity score weighting. Patients with cilta‐cel had improved PFS (HR: 0.18 [95% CI: 0.12, 0.27; p < 0.0001]), TTNT (HR: 0.15 [95% CI: 0.09, 0.22; p < 0.0001]), and OS (HR: 0.25 [95% CI: 0.13, 0.46; p < 0.0001]) versus PCT. Cilta‐cel treatment benefit was robust and consistent across all sensitivity analyses.ConclusionCilta‐cel demonstrated significantly superior effectiveness over PCT for all outcomes, highlighting its potential as an effective therapy in patients with triple‐class exposed RRMM.
Dickkopf proteins in pathological inflammatory diseases
Authors: Park Min Hee , Shin Jae Hun , Bothwell Alfred LM , Chae Wook-Jin 
Published: December 2021

AbstractThe human body encounters various challenges. Tissue repair and regeneration processes are augmented after tissue injury to reinstate tissue homeostasis. The Wnt pathway plays a crucial role in tissue repair since it induces target genes required for cell proliferation and differentiation. Since tissue injury causes inflammatory immune responses, it has become increasingly clear that the Wnt ligands can function as immunomodulators while critical for tissue homeostasis. The Wnt pathway and Wnt ligands have been studied extensively in cancer biology and developmental biology. While the Wnt ligands are being studied actively, how the Wnt antagonists and their regulatory mechanisms can modulate immune responses during chronic pathological inflammation remain elusive. This review summarizes DKK family proteins as immunomodulators, aiming to provide an overarching picture for tissue injury and repair. To this end, we first review the Wnt pathway components and DKK family proteins. Next, we will review DKK family proteins (DKK1, 2, and 3) as a new class of immunomodulatory protein in cancer and other chronic inflammatory diseases. Taken together, DKK family proteins and their immunomodulatory functions in chronic inflammatory disorders provide novel insights to understand immune diseases and make them attractive molecular targets for therapeutic intervention.
Differential expression of maturation and activation markers on NK cells in patients with active and latent tuberculosis
Authors: Albayrak Nurhan , Dirix Violette , Aerts Laetitia , Van Praet Anne , Godefroid Audrey , Dauby Nicolas , Windey Patricia , Muylle Inge , Mascart Françoise , Corbière Véronique 
Published: December 2021

AbstractNK cells were recently suggested to be important for the initial control of M. tuberculosis infection. The phenotypes of the 3 main NK blood subsets, CD56bright, CD56dim, and CD56neg cells, were characterized by flow cytometry in a cohort of 81 prospectively enrolled subjects (21 untreated patients with active tuberculosis -aTB-, 35 latently TB infected -LTBI- subjects, and 25 non-infected controls), using 9 different mAbs added to whole blood. Compared to LTBI subjects, patients with aTB had lower proportions of total NK cells, lower proportions and numbers of CD56neg cells expressing early maturation markers (CD161, NKp30, NKp46), but higher density of NKp30 and NKp46 expression on both CD56neg and CD56dim subsets, associated with higher expression of granzymes A/B. They also had higher proportions of activated CD69pos cells within all 3 NK cell subsets and, the percentage of CD69pos CD56dim cells among CD69pos and/or NKG2Cpos NK cells was identified as a potential biomarker to discriminate aTB from LTBI. LTBI subjects were in contrast characterized by higher expression of late maturation markers (CD57, KIR molecules) on the CD56neg subset, by higher proportions of NKG2CposKIRpos CD56dim NK cells, and by higher in vitro IFN-γ production than patients with aTB. Thus, the in-depth phenotypic characterization of blood NK cell subsets provides new insights on possible functional modifications and the potential role of NK cells in the control of M. tuberculosis infection in humans.
Ultrasound Strain Elastography and Contrast‐Enhanced Ultrasound in Predicting the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer: A Nomogram Integrating Ki‐67 and Ultrasound Features
Authors: Liu Qi , Tang Lei , Chen Man 
Published: December 2021

ObjectivesTo explore whether conventional elastography and contrast‐enhanced ultrasound (CEUS) combined with histopathology can monitor the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer (BC), and develop a Nomogram prediction model monitoring response to NAC.MethodsFrom February 2010 to November 2015, 91 BC patients who received NAC were recruited. The maximum diameter, stiffness, and CEUS features were assessed. Core biopsy, surgical pathology immunophenotype, and Miller‐Payne (MP) evaluation were documented. Univariate and multivariate analysis was performed using receiver operating characteristic (ROC) analysis and logistic regression analysis.ResultsThere were 37 cases showing pathological complete response (pCR) and 54 of non‐pCR. The changes of maximal diameter were correlated with MP (P < .05). The sensitivity (SEN), specificity (SPE), and area under the ROC curve (AUC) of baseline size predicting pCR were 57.40%, 70.30%, and 0.64 (P = .024). Baseline Ki‐67 index of pCR group is significantly higher than that of non‐pCR group (P = .029), and the ROC analysis of baseline Ki‐67 indicates the SEN, SPE, and AUC of 51.70%, 78.00%, and 0.638 (P = .050). When combined with size, CEUS features, stiffness, and Ki‐67 of baseline, the ROC curve shows good performance with SEN, SPE, and AUC of 70.00%, 76.19%, 0.821 (P = .004). Incorporating the change of characteristics into multivariate regression analysis, the results demonstrate excellent performance (SEN 100.00%, SPE 95.24%, AUC 0.986, P = .000).ConclusionsThe change of the maximum size was correlated with MP score, which can provide reference to predict efficacy of NAC and evaluate residual lesions. When combining with elastography, CEUS, and Ki‐67, better performance in predicting pathological response was shown.
Oceanic turbulence from a planktonic perspective
Authors: Franks Peter J. S. , Inman Bryce G. , MacKinnon Jennifer A. , Alford Matthew H. , Waterhouse Amy F. 
Published: December 2021

AbstractThe potential influences of turbulence on planktonic processes such as nutrient uptake, grazing, predation, infection, and mating have been explored in hundreds of laboratory and theoretical studies. However, the turbulence levels used may not represent those experienced by oceanic plankton, bringing into question their relevance for understanding planktonic dynamics in the ocean. Here, we take a data‐centric approach to understand the turbulence climate experienced by plankton in the ocean, analyzing over one million turbulence measurements acquired in the open ocean. Median dissipation rates in the upper 100 m were < 10−8 W kg−1, with 99% of the observations < 10−6 W kg−1. Below mixed layers, the median dissipation rate was ~ 10−10 W kg−1, with 99% of the observations < 10−7 W kg−1. Even in strongly mixing layers the median dissipation rates rarely reached 10−5 W kg−1, decreasing by orders of magnitude over 10 m or less in depth. Furthermore, episodes of intense turbulence were transient, transitioning to background levels within 10 min or less. We define three turbulence conditions in the ocean: weak (< 10−8 W kg−1), moderate (10−8–10−6 W kg−1), and strong (> 10−6 W kg−1). Even the strongest of these is much weaker than those used in most laboratory experiments. The most frequent turbulence levels found in this study are weak enough for most plankton—including small protists—to outswim them, and to allow chemical plumes and trails to persist for tens of minutes. Our analyses underscore the primary importance of planktonic behavior in driving individual interactions.
Observation of Quadratic (Charge‐2) Weyl Point Splitting in Near‐Infrared Photonic Crystals
Authors: Jörg Christina , Vaidya Sachin , Noh Jiho , Cerjan Alexander , Augustine Shyam , von Freymann Georg , Rechtsman Mikael C. 
Published: December 2021

AbstractWeyl points are point degeneracies that occur in momentum space of 3D periodic materials and are associated with a quantized topological charge. Here, the splitting of a quadratic (charge‐2) Weyl point into two linear (charge‐1) Weyl points in a 3D micro‐printed photonic crystal is observed experimentally via Fourier‐transform infrared spectroscopy. Using a theoretical analysis rooted in symmetry arguments, it is shown that this splitting occurs along high‐symmetry directions in the Brillouin zone. This micro‐scale observation and control of Weyl points is important for realizing robust topological devices in the near‐infrared.
Model predictive control of hydraulic drive unit considering input delay
Authors: Liu Kailei , Qiang Hongbin , Kang Shaopeng 
Published: December 2021

Hydraulic drive unit (HDU) is a typical actuator, but the characteristic of input delay hinders the application of many advanced control methods in HDU. First, in this paper, a mathematical model of HDU with input delay is established and the parameters are identified. Then, aiming at the input delay problem in HDU, a Smith estimated compensation model predictive control (SECMPC) strategy is proposed. On the one hand, the input delay state equation is employed to be a mathematical pattern for the state observation and predictive model. However, the combination between model predictive control (MPC) and Smith estimated compensation (SEC) is realized, the system state at k + d (d is the time delay coefficient) time is estimated in advance at k time to compensate the delay of the state. And then the prediction model based on input delay state equation is used for model prediction and rolling optimization. Thus, the delay system which is unstable is promoted to a stable system without delay. The effectiveness of SECMPC is proved with the HDU experiment and simulation; the maximum experimental displacement error of traditional MPC control is 15 mm, while that of SECMPC control is 8 mm. The SECMPC have some guiding significance for the control of systems with input delay.
Automated detection and reacquisition of motion‐degraded images in fetal HASTE imaging at 3 T
Authors: Gagoski Borjan , Xu Junshen , Wighton Paul , Tisdall M. Dylan , Frost Robert , Lo Wei‐Ching , Golland Polina , van der Kouwe Andre , Adalsteinsson Elfar , Grant P. Ellen 
Published: December 2021

PurposeFetal brain Magnetic Resonance Imaging suffers from unpredictable and unconstrained fetal motion that causes severe image artifacts even with half‐Fourier single‐shot fast spin echo (HASTE) readouts. This work presents the implementation of a closed‐loop pipeline that automatically detects and reacquires HASTE images that were degraded by fetal motion without any human interaction.MethodsA convolutional neural network that performs automatic image quality assessment (IQA) was run on an external GPU‐equipped computer that was connected to the internal network of the MRI scanner. The modified HASTE pulse sequence sent each image to the external computer, where the IQA convolutional neural network evaluated it, and then the IQA score was sent back to the sequence. At the end of the HASTE stack, the IQA scores from all the slices were sorted, and only slices with the lowest scores (corresponding to the slices with worst image quality) were reacquired.ResultsThe closed‐loop HASTE acquisition framework was tested on 10 pregnant mothers, for a total of 73 acquisitions of our modified HASTE sequence. The IQA convolutional neural network, which was successfully employed by our modified sequence in real time, achieved an accuracy of 85.2% and area under the receiver operator characteristic of 0.899.ConclusionThe proposed acquisition/reconstruction pipeline was shown to successfully identify and automatically reacquire only the motion degraded fetal brain HASTE slices in the prescribed stack. This minimizes the overall time spent on HASTE acquisitions by avoiding the need to repeat the entire stack if only few slices in the stack are motion‐degraded.
Impact of Dietary Docosahexaenoic Acid : Eicosapentaenoic Acid Ratio on Growth, Fatty Acid Composition, Lipid Metabolism, and Antioxidant Status of Juvenile Hybrid Grouper (Brown-marbled Grouper Epinephelus fuscoguttatus ♀ × Giant Grouper E. lanceolatus ♂)
Authors: Wang Chuijin , Zheng Zhi , Wang Yao , Wu QingJun , Sun Yuejia , Gao Yujie 
Published: December 2021

Abstract
The present study was conducted to evaluate the effects of dietary docosahexaenoic acid : eicosapentaenoic acid (DHA:EPA) ratio on growth, lipid metabolism, and antioxidant status of hybrid grouper (Brown-marbled Grouper Epinephelus fuscoguttatus ♀ × Giant Grouper E. lanceolatus ♀). Fish (initial body weight = 20.8 ± 0.03 g; mean ± SE) were fed six different isoproteic (53%) and isolipidic (7%) diets containing graded DHA:EPA ratios (D/E) of 0.54, 0.97, 1.51, 2.01, 2.41, and 2.85. No significant difference in weight gain was recorded in fish fed with different dietary DHA:EPA ratios. The DHA:EPA ratio in fish muscle was significantly increased as the dietary ratio increased. Relative messenger RNA expression of hepatic elongase of very long fatty acids 5 (elovl5*) and delta-6 fatty acyl desaturase (Δ6 fad*) in the D/E 2.41 and 2.85 groups was significantly higher than that in the other treatments. Lipid droplet accumulation was significantly higher in the liver of the D/E 0.54 and 0.97 groups than in the other groups. Lipogenesis-related genes (fatty acid synthase [FAS*] and acetyl coenzyme A carboxylase [ACC*]) were up-regulated by lower dietary DHA:EPA ratios (0.54 and 0.97), whereas lipolysis-related genes (peroxisome proliferator-activated receptor alpha [PPARα*] and hormone-sensitive lipase [HSL*]) were down-regulated. The expression of genes related to antioxidative capacity, including nuclear factor erythroid 2-related factor 2 (Nrf2*), manganese superoxide dismutase (MnSOD*), and peroxiredoxin (Prx*), was significantly down-regulated in the D/E 1.51 and 2.01 groups compared with other treatments, while Kelch-like ECH-associated protein 1 (Keap1*) was up-regulated. The above results suggest that dietary DHA:EPA ratio influences muscle fatty acid composition and lipid metabolism by altering the expression of lipogenesis- and lipolysis-related genes, and dietary DHA:EPA ratio may also regulate the antioxidant capacity of juvenile hybrid grouper.
Validation of Scale-Derived Ages in Wild Juvenile and Adult Steelhead Using Parental-Based Tagging
Authors: Reinhardt Leslie , Copeland Timothy , Davison Micah 
Published: December 2021

Abstract
Accurate age information is a critical component in fisheries monitoring, management, and research. The ability to assign accurate ages to fish by using nonlethal structures is vital in calculating cohort productivity for fish species with low abundances and variable life histories. A common nonlethal method to assign ages is by interpretation of patterns in scales. Validation of ages is not easily obtained for free-ranging fishes; however, the development of genetic “tags” has expanded age validation opportunities. In this study, we used parental-based genetic tagging to validate ages determined from scales collected from juvenile and adult steelhead Oncorhynchus mykiss in two streams within the Snake River basin. Juvenile scale ages were in agreement with 93% of the known ages. Adult scale ages were in agreement with 89% of the known ages. Although overall bias in juvenile ages was very low, we saw a slight positive bias in younger fish (young of the year and age 1) and a small negative bias in older juveniles (ages 2–4). A small negative bias in ages of adults was a consequence of errors in freshwater age. The errors observed did not significantly bias age compositions because the 90% confidence intervals about the age proportions based on scales contained the known proportions; therefore, scale analysis is an acceptable method for assigning ages to Snake River steelhead. We discuss the value of validated known-age scales as a reference collection, and as an illustrative use, we constructed a circulus count guide to aid technicians in identifying missing annuli and distinguishing true from false annuli. To demonstrate the use of the circulus guidelines, we reanalyzed samples with age discrepancies, applying the circulus count data and the known age to identify mistakes.