bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Interplay Between Individual and Dyadic/Common Coping in Female Patients With Cancer
Authors: Paschali Antonia , Palli Alexandra , Thomadakis Christoforos , Karademas Evangelos C. 
Published: September 2021

Abstract. Both individual and dyadic coping behaviors are important for adaptation to a severe illness. However, there is a theoretical controversy regarding the interplay between these two forms of coping. In this cross-sectional study, we examined (a) whether recently diagnosed cancer patients engage mostly with one form of coping or whether they use both in parallel; (b) the relationship of individual and supportive dyadic/common coping to emotional well-being and relationship satisfaction. Participants were 92 women recently diagnosed with cancer (mostly breast cancer) and receiving medical treatment ( Mage = 49.37 years; SD = 10.52). All had been living with their partner for at least 2 years. The parallel use of individual and supportive dyadic/common coping behaviors was frequently reported. Individual and dyadic/common coping proved to be related to each other ( p < .01), and both were related to emotional well-being and relationship satisfaction ( p < .05). The combination of high individual and high supportive dyadic/common coping was associated with greater satisfaction with the relationship ( p < .01). Patients probably use individual and dyadic coping behaviors in concert to better deal with the different aspects of their illness experience. Both types of coping should be considered in the context of personalized intervention programs to facilitate adaptation to cancer.
Quantifying Importance of Macrobenthos for Benthic‐Pelagic Coupling in a Temperate Coastal Shelf Sea
Authors: Zhang Wenyan , Neumann Andreas , Daewel Ute , Wirtz Kai , van Beusekom Justus E. E. , Eisele Annika , Ma Mengyao , Schrum Corinna 
Published: September 2021

AbstractBenthic oxygen fluxes consist mostly of advective and diffusive terms. Both terms in the German Bight exhibit a prominent annual cycle but with opposite variation patterns. To understand the driving mechanisms quantitatively, a novel 3‐D benthic‐pelagic coupled model resolving interactions among macrobenthos, bioturbation, oxygen consumption, and carbon early diagenesis was applied to reconstruct the benthic states. Simulation results show a satisfactory agreement with field data and reveal that the benthic oxygen flux is determined by not only pelagic drivers but also by internal dynamics associated with the interaction between organic carbon and macrobenthos, and bedform morphodynamics. Variation of advective flux, characterized by summer‐low and winter‐high, is mainly driven by hydrodynamics and bedform morphodynamics, while variation of diffusive flux, featured by summer‐high and winter‐low, is a compound effect of pelagic and benthic drivers with a dominant control by macrobenthos through bioturbation. The role of bioturbation in benthic oxygen consumption is twofold: (a) on the one hand, it alters the particulate organic carbon (POC) distribution in surface sediments, thereby changing the availability of POC to oxygen consumption; (b) on the other hand, it mixes oxygen down into sediments, thereby facilitating oxygen consumption. Our results indicate that the first role prevails in sandy seafloor characterized by energetic hydrodynamics, while the second role becomes increasingly important along with a weakening of bottom currents. We found that bioturbation contributes up to 87% 4% and 55% 8% of the total benthic oxygen fluxes in muddy seabed and at a regional scale (the German Bight), respectively.
Direct Viscosity Measurement of Peridotite Melt to Lower‐Mantle Conditions: A Further Support for a Fractional Magma‐Ocean Solidification at the Top of the Lower Mantle
Authors: Xie Longjian , Yoneda Akira , Katsura Tomoo , Andrault Denis , Tange Yoshinori , Higo Yuji 
Published: September 2021

AbstractAs evidenced by isotope geochemistry, the persistence of primitive reservoirs indicates that the earth's lower mantle is likely to be heterogeneous. Such heterogeneity could be a legacy from magma‐ocean (MO) solidification. The viscosity of MO is a key parameter to constrain the solidification type of MO. Here we directly measure the viscosity of peridotite (an analog of MO composition) melt at the pressure‐temperature conditions of the deep mantle, using the in situ falling sphere method. The viscosity of peridotite melt along liquidus is in the range of 38–17 mPa s at pressures from 7 to 25 GPa, which is 0.9–0.4 times of the estimation based on the viscosity of endmember compositions. Low viscosity favors fractional solidification and chemically layering of the early mantle at least to the top lower mantle, which could be a source of heterogeneity for the present mantle.
Snow Reconciles Observed and Simulated Phase Partitioning and Increases Cloud Feedback
Authors: Cesana Grégory V. , Ackerman Andrew S. , Fridlind Ann M. , Silber Israel , Kelley Maxwell 
Published: September 2021

AbstractThe surprising increase of Earth's climate sensitivity in the most recent coupled model intercomparison project (CMIP) models has been largely attributed to extratropical cloud feedback, which is thought to be driven by greater supercooled water in present‐day cloud phase partitioning (CPP). Here, we report that accounting for precipitation in the Goddard Institute for Space Studies ModelE3 radiation scheme, neglected in more than 60% of CMIP6 and 90% of CMIP5 models, systematically changes its apparent CPP and substantially increases its cloud feedback, consistent with results using CMIP models. Including precipitation in the comparison with cloud–aerosol lidar and infrared pathfinder satellite observations (CALIPSO) measurements and in model radiation schemes is essential to faithfully constrain cloud amount and phase partitioning, and simulate cloud feedbacks. Our findings suggest that making radiation schemes precipitation‐aware (missing in most CMIP6 models) should strengthen their positive cloud feedback and further increase their already high mean climate sensitivity.
Sensitivity of Upper Atmosphere to Different Characteristics of Flow Bursts in the Auroral Zone
Authors: Sheng Cheng , Deng Yue , Gabrielse Christine , Lyons Larry R. , Nishimura Yukitoshi , Heelis Roderick A. , Chen Yun‐Ju 
Published: September 2021

AbstractMeso‐scale plasma convection and particle precipitation could be significant momentum and energy sources for the ionosphere‐thermosphere (I‐T) system. Following our previous work on the I‐T response to a typical midnight flow burst, flow bursts with different characteristics (lifetime, size, and speed) have been examined systematically with Global Ionosphere‐Thermosphere Model (GITM) simulations in this study. Differences between simulations with and without additional flow bursts are used to illustrate the impact of flow bursts on the I‐T system. The neutral density perturbation due to a flow burst increases with the lifetime, size, and flow speed of the flow burst. It was found that the neutral density perturbation is most sensitive to the size of a flow burst, increasing from ∼0.3% to ∼1.3% when the size changes from 80 to 200 km. A westward‐eastward asymmetry has been identified in neutral density, wind, and temperature perturbations, which may be due to the changing of the forcing location in geographic coordinates and the asymmetrical background state of the I‐T system. In addition to midnight flow bursts, simulations with flow bursts centered at noon, dawn, and dusk have also been carried out. A flow burst centered at noon (12.0 Local Time [LT], 73°N) produces the weakest perturbation, and a flow burst centered at dusk (18.0 LT, 71°N) produces the strongest. Single‐cell and two‐cell flow bursts induce very similar neutral density perturbation patterns.
Non-line-of-sight reconstruction with signal–object collaborative regularization
Authors: Liu Xintong , Wang Jianyu , Li Zhupeng , Shi Zuoqiang , Fu Xing , Qiu Lingyun 
Published: September 2021

AbstractNon-line-of-sight imaging aims at recovering obscured objects from multiple scattered lights. It has recently received widespread attention due to its potential applications, such as autonomous driving, rescue operations, and remote sensing. However, in cases with high measurement noise, obtaining high-quality reconstructions remains a challenging task. In this work, we establish a unified regularization framework, which can be tailored for different scenarios, including indoor and outdoor scenes with substantial background noise under both confocal and non-confocal settings. The proposed regularization framework incorporates sparseness and non-local self-similarity of the hidden objects as well as the smoothness of the signals. We show that the estimated signals, albedo, and surface normal of the hidden objects can be reconstructed robustly even with high measurement noise under the proposed framework. Reconstruction results on synthetic and experimental data show that our approach recovers the hidden objects faithfully and outperforms state-of-the-art reconstruction algorithms in terms of both quantitative criteria and visual quality.
Rapid, continuous projection multi-photon 3D printing enabled by spatiotemporal focusing of femtosecond pulses
Authors: Somers Paul , Liang Zihao , Johnson Jason E. , Boudouris Bryan W. , Pan Liang , Xu Xianfan 
Published: September 2021

AbstractThere is demand for scaling up 3D printing throughput, especially for the multi-photon 3D printing process that provides sub-micrometer structuring capabilities required in diverse fields. In this work, high-speed projection multi-photon printing is combined with spatiotemporal focusing for fabrication of 3D structures in a rapid, layer-by-layer, and continuous manner. Spatiotemporal focusing confines printing to thin layers, thereby achieving print thicknesses on the micron and sub-micron scale. Through projection of dynamically varying patterns with no pause between patterns, a continuous fabrication process is established. A numerical model for computing spatiotemporal focusing and imaging is also presented which is verified by optical imaging and printing results. Complex 3D structures with smooth features are fabricated, with millimeter scale printing realized at a rate above 10−3 mm3 s−1. This method is further scalable, indicating its potential to make fabrications of 3D structures with micro/nanoscale features in a practical time scale a reality.
Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a propensity score-matched analysis
Authors: Kurosawa Shuhei , Mizuno Shohei , Arai Yasuyuki , Masuko Masayoshi , Kanda Junya , Kohno Kentaro , Onai Daishi , Fukuda Takahiro , Ozawa Yukiyasu , Katayama Yuta , Tanaka Masatsugu , Ikegame Kazuhiro , Uchida Naoyuki , Eto Tetsuya , Ota Shuichi , Tanaka Junji , Ichinohe Tatsuo , Atsuta Yoshiko , Yanada Masamitsu 
Published: September 2021

AbstractThe present study evaluated outcomes and prognostic factors in adult patients with acute myeloid leukemia (AML) after syngeneic hematopoietic stem cell transplantation (HSCT). Among patients in first complete remission (CR1), outcomes of syngeneic HSCT (Syn) were compared with those of autologous HSCT (Auto), allogeneic HSCT from human leukocyte antigen (HLA)-matched sibling donor (MSD), or allogeneic HSCT from HLA-matched unrelated donor (MUD). Among 11,866 patients receiving first HSCT, 26 in the Syn group were analyzed. The 5-year overall survival (OS) rate, the cumulative incidence of relapse, and the cumulative incidence of non-relapse mortality (NRM) were 47.8%, 59.6%, and 4.6%, respectively. The OS was significantly better in patients in CR1 (n = 13) than in patients in non-CR1 (P = 0.012). Furthermore, 39 patients in CR1 each were assigned to the Auto, MSD, and MUD groups using propensity score matching. The 5-year OS in the Syn (68.4%) was not significantly different from those in the Auto (55.9%, P = 0.265), MSD (62.4%, P = 0.419), or MUD (63.7%, P = 0.409) groups. A higher relapse in the Syn than in the MSD and MUD groups was offset by lower NRM. In summary, syngeneic HSCT might be an alternative option for AML patients in CR1.
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers
Authors: Loo Ser Yue , Syn Nicholas L. , Koh Angele Pei-Fern , Teng Janet Cheng-Fei , Deivasigamani Amudha , Tan Tuan Zea , Thike Aye Aye , Vali Shireen , Kapoor Shweta , Wang Xiaoyuan , Wang Jiong Wei , Tan Puay Hoon , Yip George W. , Sethi Gautam , Huang Ruby Yun-Ju , Hui Kam Man , Wang Lingzhi , Goh Boon Cher , Kumar Alan Prem 
Published: September 2021

AbstractClinical trials repurposing peroxisome proliferator-activated receptor-gamma (PPARγ) agonists as anticancer agents have exhibited lackluster efficacy across a variety of tumor types. Here, we report that increased PPARG expression is associated with a better prognosis but is anticorrelated with histone deacetylase (HDAC) 1 and 2 expressions. We show that HDAC overexpression blunts anti-proliferative and anti-angiogenic responses to PPARγ agonists via transcriptional and post-translational mechanisms, however, these can be neutralized with clinically approved and experimental HDAC inhibitors. Supporting this notion, concomitant treatment with HDAC inhibitors was required to license the tumor-suppressive effects of PPARγ agonists in triple-negative and endocrine-refractory breast cancer cells, and combination therapy also restrained angiogenesis in a tube formation assay. This combination was also synergistic in estrogen receptor-alpha (ERα)–positive cells because HDAC blockade abrogated ERα interference with PPARγ-regulated transcription. Following a pharmacokinetics optimization study, the combination of rosiglitazone and a potent pan-HDAC inhibitor, LBH589, stalled disease progression in a mouse model of triple-negative breast cancer greater than either of the monotherapies, while exhibiting a favorable safety profile. Our findings account for historical observations of de-novo resistance to PPARγ agonist monotherapy and propound a therapeutically cogent intervention against two aggressive breast cancer subtypes.
Expanding the known phenotype of Mullegama–Klein–Martinez syndrome in male patients
Authors: Freyberger Fiona , Kokotović Tomislav , Krnjak Goran , Frković Sanda Huljev , Nagy Vanja 
Published: September 2021

AbstractHere, we report a novel case of a male patient with a hemizygous missense variant in STAG2 (p.Tyr159His) resulting in Mullegama–Klein–Martinez syndrome (MKMS), a rare X-linked cohesinopathy. He shares distinct clinical features with a previously reported male patient carrying the STAG2 variant p.Tyr159Cys, suggesting that this phenotype is determined by the position of the mutation. Additionally, our patient exhibits symptoms not previously associated with MKMS, expanding the known clinical phenotype of this rare disease.
γ-Selective C(sp3)–H amination via controlled migratory hydroamination
Authors: Lee Changseok , Seo Huiyeong , Jeon Jinwon , Hong Sungwoo 
Published: September 2021

AbstractRemote functionalization of alkenes via chain walking has generally been limited to C(sp3)–H bonds α and β to polar-functional units, while γ-C(sp3)–H functionalization through controlled alkene transposition is a longstanding challenge. Herein, we describe NiH-catalyzed migratory formal hydroamination of alkenyl amides achieved via chelation-assisted control, whereby various amino groups are installed at the γ-position of aliphatic chains. By tuning olefin isomerization and migratory hydroamination through ligand and directing group optimization, γ-selective amination can be achieved via stabilization of a 6-membered nickellacycle by an 8-aminoquinoline directing group and subsequent interception by an aminating reagent. A range of amines can be installed at the γ-C(sp3)–H bond of unactivated alkenes with varying alkyl chain lengths, enabling late-stage access to value-added γ-aminated products. Moreover, by employing picolinamide-coupled alkene substrates, this approach is further extended to δ-selective amination. The chain-walking mechanism and pathway selectivity are investigated by experimental and computational methods.
Structural basis of gating modulation of Kv4 channel complexes
Authors: Kise Yoshiaki , Kasuya Go , Okamoto Hiroyuki H. , Yamanouchi Daichi , Kobayashi Kan , Kusakizako Tsukasa , Nishizawa Tomohiro , Nakajo Koichi , Nureki Osamu 
Published: September 2021

AbstractModulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart1,2. Native Kv4 tetrameric channels form macromolecular ternary complexes with two auxiliary β-subunits—intracellular Kv channel-interacting proteins (KChIPs) and transmembrane dipeptidyl peptidase-related proteins (DPPs)—to evoke rapidly activating and inactivating A-type currents, which prevent the backpropagation of action potentials1–5. However, the modulatory mechanisms of Kv4 channel complexes remain largely unknown. Here we report cryo-electron microscopy structures of the Kv4.2–DPP6S–KChIP1 dodecamer complex, the Kv4.2–KChIP1 and Kv4.2–DPP6S octamer complexes, and Kv4.2 alone. The structure of the Kv4.2–KChIP1 complex reveals that the intracellular N terminus of Kv4.2 interacts with its C terminus that extends from the S6 gating helix of the neighbouring Kv4.2 subunit. KChIP1 captures both the N and the C terminus of Kv4.2. In consequence, KChIP1 would prevent N-type inactivation and stabilize the S6 conformation to modulate gating of the S6 helices within the tetramer. By contrast, unlike the reported auxiliary subunits of voltage-gated channel complexes, DPP6S interacts with the S1 and S2 helices of the Kv4.2 voltage-sensing domain, which suggests that DPP6S stabilizes the conformation of the S1–S2 helices. DPP6S may therefore accelerate the voltage-dependent movement of the S4 helices. KChIP1 and DPP6S do not directly interact with each other in the Kv4.2–KChIP1–DPP6S ternary complex. Thus, our data suggest that two distinct modes of modulation contribute in an additive manner to evoke A-type currents from the native Kv4 macromolecular complex.
The three major axes of terrestrial ecosystem function
Authors: Migliavacca Mirco , Musavi Talie , Mahecha Miguel D. , Nelson Jacob A. , Knauer Jürgen , Baldocchi Dennis D. , Perez-Priego Oscar , Christiansen Rune , Peters Jonas , Anderson Karen , Bahn Michael , Black T. Andrew , Blanken Peter D. , Bonal Damien , Buchmann Nina , Caldararu Silvia , Carrara Arnaud , Carvalhais Nuno , Cescatti Alessandro , Chen Jiquan , Cleverly Jamie , Cremonese Edoardo , Desai Ankur R. , El-Madany Tarek S. , Farella Martha M. , Fernández-Martínez Marcos , Filippa Gianluca , Forkel Matthias , Galvagno Marta , Gomarasca Ulisse , Gough Christopher M. , Göckede Mathias , Ibrom Andreas , Ikawa Hiroki , Janssens Ivan A. , Jung Martin , Kattge Jens , Keenan Trevor F. , Knohl Alexander , Kobayashi Hideki , Kraemer Guido , Law Beverly E. , Liddell Michael J. , Ma Xuanlong , Mammarella Ivan , Martini David , Macfarlane Craig , Matteucci Giorgio , Montagnani Leonardo , Pabon-Moreno Daniel E. , Panigada Cinzia , Papale Dario , Pendall Elise , Penuelas Josep , Phillips Richard P. , Reich Peter B. , Rossini Micol , Rotenberg Eyal , Scott Russell L. , Stahl Clement , Weber Ulrich , Wohlfahrt Georg , Wolf Sebastian , Wright Ian J. , Yakir Dan , Zaehle Sönke , Reichstein Markus 
Published: September 2021

AbstractThe leaf economics spectrum1,2 and the global spectrum of plant forms and functions3 revealed fundamental axes of variation in plant traits, which represent different ecological strategies that are shaped by the evolutionary development of plant species2. Ecosystem functions depend on environmental conditions and the traits of species that comprise the ecological communities4. However, the axes of variation of ecosystem functions are largely unknown, which limits our understanding of how ecosystems respond as a whole to anthropogenic drivers, climate and environmental variability4,5. Here we derive a set of ecosystem functions6 from a dataset of surface gas exchange measurements across major terrestrial biomes. We find that most of the variability within ecosystem functions (71.8%) is captured by three key axes. The first axis reflects maximum ecosystem productivity and is mostly explained by vegetation structure. The second axis reflects ecosystem water-use strategies and is jointly explained by variation in vegetation height and climate. The third axis, which represents ecosystem carbon-use efficiency, features a gradient related to aridity, and is explained primarily by variation in vegetation structure. We show that two state-of-the-art land surface models reproduce the first and most important axis of ecosystem functions. However, the models tend to simulate more strongly correlated functions than those observed, which limits their ability to accurately predict the full range of responses to environmental changes in carbon, water and energy cycling in terrestrial ecosystems7,8.
A putatively extinct higher taxon of Spirotrichea (Ciliophora) from the Lower Cretaceous of Brazil
Authors: da Silva Paiva Thiago , de Souza Carvalho Ismar 
Published: September 2021

AbstractFossil microeukaryotes are key elements for understanding ancient ecosystems at microscopic level and improving the knowledge on the diversification of microbial life as a whole. We describePalaeohypothrix bahiensisgen.etsp. nov., an exceptionally well-preserved Lower Cretaceous (Berriasian–Barremian; 145–125 Mya) amber-entrapped microeukaryote, identified as a spirotrich ciliate. The preservation of structures interpreted as the nuclear apparatus and remains of the ciliature revealed a novel ground plan, not found in modern Spirotrichea, thus representing a putatively extinct higher taxon lineage, viz. the Palaeohypotricha nov. tax. Based on cladistic analysis, the new taxon is hypothesized as phylogenetically related to the Protohypotrichia.
Transient hexagonal structures in sheared emulsions of isotropic inclusions on smectic bubbles in microgravity conditions
Authors: Dolganov P. V. , Shuravin N. S. , Dolganov V. K. , Kats E. I. , Stannarius R. , Harth K. , Trittel T. , Park C. S. , Maclennan J. E. 
Published: September 2021

AbstractWe describe the collective behavior of isotropic droplets dispersed over a spherical smectic bubble, observed under microgravity conditions on the International Space Station (ISS). We find that droplets can form two-dimensional hexagonal structures changing with time. Our analysis indicates the possibility of spatial and temporal periodicity of such structures of droplets. Quantitative analysis of the hexagonal structure including the first three coordination circles was performed. A peculiar periodic-in-time ordering of the droplets, related to one-dimensional motion of droplets with non-uniform velocity, was found.