bluuebunny/crossref_metadata_2025_split huggingface dataset:
Illustrating the unknowable: Women paleoartists who drew ancient vertebrates
Authors: Turner* Susan , Berta Annalisa 
Published: September 2021

ABSTRACT
Women have contributed to “paleoart” working in collaboration with scientists, using vertebrate fossils to reconstruct vanished worlds, and directly shaping the way humans imagine the distant past. “Backboned” animals of former times have been portrayed singly or in groups and were often set in landscape scenes. Women paleoartists in America and Europe began working in the nineteenth century often through family association, such as pioneers Orra White Hitchcock, Graceanna Lewis, and Mary Morland Buckland. Mainly using traditional two-dimensional styles, they portrayed ancient vertebrate fossils in graphite and ink drawings. Paleoartist Alice Bolingbroke Woodward introduced vibrant pen and watercolor reconstructions. Although female paleoartists were initially largely unrecognized, in the twentieth century they gained notice by illustrating important books on prehistoric vertebrate life. Paid employment and college and university training increased by the late nineteenth to early twentieth centuries, with larger institutions providing stable jobs. The “Dinosaur Renaissance” of the late 1960s gave a boost to new paleo-artistry. Women paleoartists became more prominent in the later twentieth to twenty-first centuries with the development of new art techniques, computer-based art, and use of the internet. Increasingly, there is encouragement and support for women paleoartists through the Science, Technology, Engineering, the Arts, and Mathematics (STEAM) movement.
Asymptotics of the Far Fields of Internal Gravity Waves Excited by a Source of Radial Symmetry
Authors: Bulatov V. V. , Vladimirov Yu. V. 
Published: September 2021

Abstract—
The problem of the far field of internal gravity waves generated by a perturbation source of radial symmetry aroused at an initial instant of time is solved. The constant model distribution of the buoyancy frequency is considered and, using the Fourier–Hankel transform, an analytical solution to the problem is obtained in the form of the sum of wave modes. Asymptotics of the solutions that describe the spatial-temporal characteristics of elevation of the isopycnic lines and the vertical and horizontal velocity components far from the perturbation source are obtained. The asymptotics of the components of the wave field are expressed in terms of the square of the Airy function and its derivatives in the neighborhood of the wave fronts of an individual wave mode. The exact and asymptotic results are compared and it is shown that the asymptotic method makes it possible to calculate effectively the far wave fields at times of the order of ten and more of the Brunt–Väisälä periods.
Multiyear defoliations in southern New England increases oak mortality
Authors: Ward Jeffrey S. , Jones Chad C. , Barsky Joseph P. 
Published: September 2021

After decades of multiyear defoliation episodes in southern New England, Lymantria dispar dispar (previously gypsy moth) populations diminished with the appearance of the L. dispar fungus in 1989. Multiyear defoliations did not occur again until 2015–2018. To assess the impact of the return of multiyear defoliations, we examined 3095 oaks on 29 permanent study areas in Connecticut and Rhode Island that were established at least 11 years before the latest outbreaks. Pre-defoliation stand-level oak mortality averaged 2% (3-year basis). Post-defoliation mortality did not differ between managed and unmanaged stands but was much higher in severely defoliated stands (36%) than in stands with moderate (7%) or low to no defoliation (1%). Pre-defoliation mortality of individual trees differed among species, was lower for larger diameter trees and on unmanaged than managed stands. Post-defoliation mortality on plots with no to moderate defoliation was similar to pre-defoliation mortality levels. Following multiyear defoliations, white oak (Quercus alba L.) mortality was higher than for northern red oak (Quercus rubra L.) and black oak (Q. velutina Lam.). There was weak evidence that mortality was elevated on stands with higher basal area following severe defoliation. Natural resource managers should not assume that oaks that survived earlier multiyear defoliations episodes will survive future multiyear outbreaks, possibly because trees are older.
Incunabula in Communities of Canonesses Regular and Tertiaries Related to the Devotio Moderna
Authors: Dlabačová Anna , Stoop Patricia 
Published: September 2021

Abstract
This contribution discusses the hitherto overlooked ownership of the earliest printed books (incunabula) by Netherlandish female religious communities of tertiaries and canonesses regular connected to the religious reform movement of the Devotio moderna. Studies of book ownership and book collections in these communities have tended to focus on manuscripts. From the last decades of the fifteenth century onwards, however, these religious women increasingly came in contact with printed books, even though the involvement of the Devotio moderna with the printing press was limited. The discussion focuses on the channels via which tertiaries and canonesses acquired books produced by commercially operating printers, the ways in which incunabula affected what these (semi-)religious women read, as well as the ratio between printed books in Latin and the vernacular, and their function(s) within these communities. Thus the essay intends to sketch a preliminary image of the role of incunabula in female convents, and advocates a more inclusive approach of female religious book ownership.
Resveratrol improves the iron deficiency adaptation of Malus baccata seedlings by regulating iron absorption
Authors: Zheng Xiaodong , Chen Huifang , Su Qiufang , Wang Caihong , Sha Guangli , Ma Changqing , Sun Zhijuan , Yang Xueqing , Li Xiangyang , Tian Yike 
Published: September 2021

Abstract
Background
Resveratrol (Res), a phytoalexin, has been widely reported to participate in plant resistance to fungal infections. However, little information is available on its role in abiotic stress, especially in iron deficiency stress. Malus baccata is widely used as apple rootstock in China, but it is sensitive to iron deficiency.

Results
In this study, we investigated the role of exogenous Res in M. baccata seedings under iron deficiency stress. Results showed that applying 100 μM exogenous Res could alleviate iron deficiency stress. The seedlings treated with Res had a lower etiolation rate and higher chlorophyll content and photosynthetic rate compared with the apple seedlings without Res treatment. Exogenous Res increased the iron content in the roots and leaves by inducing the expression of MbAHA genes and improving the H+-ATPase activity. As a result, the rhizosphere pH decreased, iron solubility increased, the expression of MbFRO2 and MbIRT1 was induced, and the ferric-chelated reductase activity was enhanced to absorb large amounts of Fe2+ into the root cells under iron deficiency conditions. Moreover, exogenous Res application increased the contents of IAA, ABA, and GA3 and decreased the contents of DHZR and BL for responding to iron deficiency stress indirectly. In addition, Res functioned as an antioxidant that strengthened the activities of antioxidant enzymes and thus eliminated reactive oxygen species production induced by iron deficiency stress.

Conclusion
Resveratrol improves the iron deficiency adaptation of M. baccata seedlings mainly by regulating iron absorption.
Severe spruelike enteropathy and collagenous colitis caused by olmesartan
Authors: Kaneko Shiho , Matsuda Kana , Mizuta Yasuko , Shiratori Shoya , Kishi Kazuma , Nakamura Akihisa , Yagisawa Masataka , Ehira Nobuyuki , Uebayashi Minoru , Kobayashi Hiroya 
Published: September 2021

Abstract
Background
Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lymphocytic gastritis and colitis occur in some patients. We report the case of a 73-year-old Japanese man with a 2-month clinical history of severe diarrhea and weight loss. There were few reports in which spruelike enteropathy and collagenous colitis were both observed and could be followed up.

Case presentation
We report a case of a 73-year-old man with a 2-month clinical history of severe diarrhea and weight loss. He had taken olmesartan for hypertension treatment for 5 years. Endoscopic examination with biopsies revealed intestinal villous atrophy and collagenous colitis. Suspecting enteropathy caused by olmesartan, which was discontinued on admission because of hypotension, we continued to stop the drug. Within 3 weeks after olmesartan discontinuation, his clinical symptoms improved. After 3 months, follow-up endoscopy showed improvement of villous atrophy but not of the thickened collagen band of the colon. However, the mucosa normalized after 6 months, histologically confirming that the preexistent pathology was finally resolved.

Conclusions
This report presents a case in which spruelike enteropathy and collagenous colitis were both observed and could be followed up. In unexplained cases of diarrhea, medication history should be reconfirmed and this disease should be considered a differential diagnosis.
The host immune response of a discharged COVID-19 patient with twice reemergence of SARS-CoV-2: a case report
Authors: Zao Xiaobin , Zhou Yang , Liang Yijun , Cao Xu , Chen Hening , Li Xiaoke , Ye Yong’an 
Published: September 2021

Abstract
Background
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. There have been reports that long-term SARS-CoV-2 RNA shedding and re-infection of COVID-19 patients existed. However, the specific mechanism, diagnosis, and treatment of COVID-19 are still unclarified.

Case presentation
In this case, we reported a 64-year-old patient who had a long-term course of COVID-19 for 174 days with two retests of SARS-CoV-2 RNA positive after discharging from the hospital. The patient’s serum immunoglobulin G (IgG) of SARS-CoV-2 tested positive after the initial infection. And during treatment, the CD4 + T cell count and ratio to peripheral blood mononuclear cell (PBMC) were in dynamic change.

Conclusions
Our results suggested that the host immune system responded with IgG production after SARS-CoV-2 infection, but was not protective enough for the patient. The reemergence of SARS-CoV-2 could be related to the cell count and proportion of CD4 + T cells in PBMC. And the increase of CD4 + T cells after treatment may help to clear the virus.
Meningitis retention syndrome caused by varicella zoster virus in a patient without a rash: a case report
Authors: Kenzaka Tsuneaki , Goda Ken , Kumabe Ayako 
Published: September 2021

Abstract
Background
Meningitis retention syndrome (MRS) is a rare condition that presents with acute urinary retention as a complication of aseptic meningitis. Cases of MRS due to varicella zoster virus (VZV) infection without a rash are rare. We report the case of a patient who had no signs of meningitis or VZV infection, including a rash.

Case presentation
A 58-year-old man presented with dysesthesia of the lower limbs and acute urinary retention. He had fever but no rash and no signs of meningitis. He was diagnosed to have VZV infection based on the detection of VZV DNA in the cerebrospinal fluid. He responded satisfactorily to a course of intravenous acyclovir and experienced no sequelae during a 2-year follow-up period.

Conclusion
MRS due to aseptic meningitis of viral origin should be considered in the differential diagnosis of acute urinary retention even in the absence of specific signs and symptoms of meningitis or a suggestive rash.
LDLR gene polymorphism (rs688) affects susceptibility to cardiovascular disease in end-stage kidney disease patients
Authors: Buraczynska Monika , Jacob Jerry , Gwiazda-Tyndel Karolina , Ksiazek Andrzej 
Published: September 2021

Abstract
Background
The low-density lipoprotein receptor (LDLR) plays a significant role in maintaining the cellular cholesterol homeostasis. Mutations in the LDLR gene can lead to a significant rise in plasma LDL levels that may result in an increased risk of atherosclerosis and coronary heart disease. The purpose of this study was to assess the potential association of the LDLR rs688 polymorphism with cardiovascular disease (CVD) in patients with end-stage kidney disease (ESKD) undergoing hemodialysis.

Methods
In this case-control study the polymorphism was genotyped by the allele specific PCR method in 800 patients with ESKD and 500 healthy controls. The genotype and allele distribution was compared in subgroups of patients with CVD (552) versus those without CVD (248).

Results
A significant difference was observed in genotype distribution among ESKD patients and healthy controls. The frequencies of the T allele and TT genotype in ESKD group were significantly higher, with OR (95% CI) 2.2 (1.87–2.6), p <  0.0001 and 5.84 (3.94–8.65), p <  0.0001, respectively. In the he ESKD cohort the distribution of the rs688 was compared between CVD+ and CVD- subgroups. A strong association of the polymorphism with the CVD risk was observed in this analysis. The frequencies of the T allele and TT genotype were significantly higher in CVD+ subgroup, with OR (95% CI) 3.4 (2.71–4.26), p <  0.0001 and 13.2 (7.87–22.09), p <  0.0001, respectively. A multivariate logistic regression analysis was performed to estimate the association between rs688 T variant and risk of CVD. After adjustment for age, sex, BMI, hypertension and diabetes, both CT and TT genotypes were associated with an increased risk of developing CVD in the dominant, recessive and codominant models of inheritance. No significant differences in serum LDL cholesterol levels were found when compared between genotypes.

Conclusions
The present study is the first to demonstrate the association of the LDLR gene polymorphism with increased susceptibility to cardiovascular disease in ESKD patients. This finding needs further investigation to confirm that LDLR rs688 might be a novel genetic risk factor with some prognostic capacity for CVD in ESKD patients.
eCross-cultural adaptation of the spine oncology-specific SOSGOQ2.0 questionnaire to German language and the assessment of its validity and reliability in the clinical setting
Authors: Datzmann T. , Kisel W. , Kramer J. , Dreimann M. , Müller-Broich J. D. , Netzer C. , Schaser K. D. , Schmitt J. , Disch A. C. ,   the Tumor Study Group, Spine Section of the German Society of Orthopaedic and Trauma Surgeons (DGOU), Schaser K. D. , Disch A. C. , Dreimann M. , Müller-Broich J. D. , Netzer C. , Sauer D. , Heyde C. , Schmidt R. , Kreinest M. , Arand M. , Liljenqvist U. 
Published: September 2021

Abstract
Background
The recently developed Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) was proven a valid and reliable instrument measuring health-related quality of life (HRQOL) for patients with spinal malignancies. A German version was not available.

Objective
A cross-cultural adaptation of the SOSGOQ2.0 to the German language and its multicenter evaluation.

Methods
In a multistep process, a cross-cultural adaptation of the SOSGOQ2.0 was conducted. Subsequently, a multicenter, prospective observational cohort study was initiated to assess the reliability and validity of the German adaptation. To assess external construct validity of the cross-cultural adapted questionnaire, a comparison to the established questionnaire QLQ-C30 from the European Organisation for Research and Treatment of Cancer was conducted. Mean-difference plots were used to measure the agreement between the questionnaires in total score and by domain (deviation from mean up to 10% allowed). Further reliability and validity tests were carried out. Change to baseline was analysed 3–16 weeks later after different interventions occurred. Clinically relevant thresholds in comparison to the EORTC QLQ-C30 questionnaire were evaluated by ROC curve analysis.

Results
We could enroll 113 patients from four different university hospitals (58 females, 55 males). Mean age was 64.11 years (sd 11.9). 80 patients had an ECOG performance status of 2 or higher at baseline. External construct validity in comparison to the EORTC QLQ-C30 questionnaire in total score and by domain was confirmed (range of deviation 4.4 to 9.0%). Good responsiveness for the domains Physical Functioning (P < .001) and Pain (P < .001) could be shown. The group mean values also displayed a difference in the domains of Social Functioning (P = .331) and Mental Health (P = .130), but not significant. The minimum clinically relevant threshold values for the questionnaire ranged from 4.0 to 7.5 points.

Conclusions
According to our results, the cross-cultural adapted questionnaire is a reliable and valid tool to measure HRQOL in German speaking patients with spinal malignancies. Especially the domains Physical Functioning and Pain showed overall good psychometric characteristics. In this way, a generic questionnaire, such as the EORTC QLQ-C30, can be usefully supplemented by spine-specific questions to increase the overall accuracy measuring HRQOL in patients with spinal malignancies.
Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital
Authors: Shimizu Norihiro , Oshitari Toshiyuki , Yotsukura Jiro , Yokouchi Hirotaka , Baba Takayuki , Yamamoto Shuichi 
Published: September 2021

Abstract
Background
The purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan.

Methods
We conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. In addition, we examined the annual changes in the major types of tumors including malignant lymphomas and IgG4-related diseases (IgG4-RDs).

Results
There were 270 conjunctival or eyelid tumors with 166 benign and 104 malignant. There were 102 orbital tumors with 55 benign, 47 malignant tumors, and 21 cases of IgG4-RDs. Ten cases of adenoma (2.7%), another benign tumor, was also diagnosed. The major malignant tumors were malignant lymphoma in 74 cases, sebaceous gland carcinoma (SGC) in 28 cases, basal cell carcinoma in 15 cases, and squamous cell carcinoma in 8 cases. The SGCs were the most common malignant eyelid tumor at 54%. Among the malignant lymphomas, extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue type, MALT lymphomas, was the most common at 51 cases and the second most common was the diffuse large B-cell lymphoma at 11 cases. The ratio of MALT lymphomas to that of all malignant lymphomas increased significantly with years. The serum IgG4 values were measured more often in the last 5 years (70%) than in the former 5 years (33%).

Conclusions
We conclude that malignant lymphoma is a major malignant tumor in Japan and pathological biopsies should be done proactively to prevent missing IgG4-positive MALT lymphomas.
Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children’s Study (JECS)
Authors: Nakamura Mari , Matsumura Kenta , Ohnuma Yoshiko , Yoshida Taketoshi , Tsuchida Akiko , Hamazaki Kei , Inadera Hidekuni ,   the Japan Environment and Children’s Study Group, Kamijima Michihiro , Yamazaki Shin , Ohya Yukihiro , Kishi Reiko , Yaegashi Nobuo , Hashimoto Koichi , Mori Chisato , Ito Shuichi , Yamagata Zentaro , Inadera Hidekuni , Nakayama Takeo , Iso Hiroyasu , Shima Masayuki , Kurozawa Youichi , Suganuma Narufumi , Kusuhara Koichi , Katoh Takahiko 
Published: September 2021

Abstract
Background
The association between delivery mode and subsequent development of diseases is a growing area of research. Cesarean delivery affects the diversity of the microbiota in the infant gut, which may be associated with gastrointestinal disorders, including functional constipation, in infants. In this study, we investigated the association between delivery mode and prevalence of functional constipation in 3-year-old Japanese toddlers.

Methods
This study used data from the Japan Environment and Children’s Study, an ongoing nationwide birth cohort study. We analyzed 71,878 toddler–mother pairs. The presence of functional constipation was determined according to the Rome III diagnostic criteria. Odds ratios and 95% confidence intervals were calculated using logistic regression analysis.

Results
The prevalence of functional constipation in 3-year-old Japanese toddlers was estimated to be 12.3%. Logistic regression analysis revealed that the prevalence of functional constipation was higher in toddlers born by cesarean delivery (13.1%) compared with those born by vaginal delivery (12.1%), independent of 22 confounders (adjusted odds ratios = 1.064, 95% confidence interval = 1.004–1.128).

Conclusions
We determined the prevalence of functional constipation in 3-year-old Japanese toddlers and found that delivery mode was associated with the prevalence of functional constipation in Japanese toddlers.
Obesity determinants among Malaysian 12-year old school adolescents: findings from the HAT study
Authors: Ahmad Aryati , Zulaily Nurzaime , Shahril Mohd Razif , Wafa Sharifah Wajihah , Mohd Amin Rahmah , Piernas Carmen , Ahmed Amran 
Published: September 2021

AbstractBackgroundChildhood obesity has been associated with increased odds of adult obesity and co-morbidities in later life. Finding the key determinants may help in designing the most appropriate and effective interventions to prevent obesity. This study aimed to identify the determinants of obesity among school adolescents in a sub-urban state of Malaysia.MethodsThis cross-sectional study involved 1,404 school adolescents aged 12 years (46% boys and 54% girls). Socio-demographic, dietary and physical activity data were collected using questionnaires whilst body weight and height were measured and body mass index was classified based on WHO BMI-for-age Z-scores cut-off.ResultsA multivariable linear regression model showed that BMI z-score was positively associated with parents’ BMI (P<0.001), birth weight (P=0.003), and serving size of milk and dairy products (P=0.036) whilst inversely associated with household size (P=0.022). Overall, 13.1% of the variances in BMI Z-scores were explained by parents’ BMI, birth weight, servings of milk and dairy products and household size.ConclusionThis study found important determinants of body weight status among adolescents mainly associated with family and home environmental factor. This evidence could help to form the effective and tailored strategies at the earliest stage to prevent obesity in this population.