bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin 20 receptor A expression in colorectal cancer and its clinical significance
Authors: Liu Rui , Yin Honghao , Sun Xin , Liu Songyi , Wang Ang , Wu Ying , Yuan Yuan , Gong Yuehua , Xing Chengzhong 
Published: November 2021

Background
Interleukin 20 receptor A (IL20RA) has been shown to play a role in the establishment and progression of multiple tumors. However, the expression of this protein in colorectal cancer (CRC) and its correlation with the clinicopathological parameters of CRC have remained unclear.

Methods
A total of 323 paraffin sections including CRC tissues and adjacent normal tissues after surgery were collected. IL20RA protein expression was detected by immunohistochemical staining. The difference expression of IL20RA mRNA between CRC and normal tissues was also explored in the Oncomine and GEO databases. In addition, the IL20RA-related differentially expressed genes were analyzed in TCGA database and enrichment analysis was conducted to explore the cell functions and pathways related to IL20RA expression.

Results
There was increased IL20RA expression in CRC compared with that in normal tissues. High IL20RA expression was associated with greater tumor diameter, lymph node metastasis, and poor TNM stage in CRC, while also being suggestive of poor prognosis. The main pathways of IL20RA-related differentially expressed genes in TCGA were protein heterodimerization activity, oxygen binding, oxygen transporter activity, hormone activity, and lipid transporter activity. Meanwhile, IL20RA-related differentially expressed genes were mainly enriched in peroxidase, nucleotide stimulant repair, fatty acid metabolism, basal transcription factor, and RNA degradation.

Conclusions
IL20RA might have a role as a biomarker for CRC. Its upregulation might contribute to an aggressive phenotype in CRC. IL20RA’s involvement in the development and progression of CRC might occur through it affecting fatty acid metabolism, oxygen binding, oxygen transport, and hormone activity.
Carfentrazone Plus Pyroxasulfone Combinations for Weed Control in Peanut (Arachis hypogaea L.)
Authors: Grichar W. James , A. Dotray Peter , Baughman Todd 
Published: November 2021

Aims: To determine peanut response and weed control following the use of carfentrazone plus pyroxasulfone (C + P).
Study Design: Randomized complete block design with 3-4 reps depending on location.
Place and Duration of Study: Studies were conducted during the 2015 and 2016 growing seasons in south Texas near Yoakum (29.276o N, 97.123o W), the High Plains of Texas near Lamesa (32.769o N, 101.977o W) or Brownfield (33.104o N, 102.161o W), and southwestern Oklahoma near Ft. Cobb (35.091o N, 98.275o W).
Methodology: Plots were infested with naturally occurring weed populations. Pendimethalin was applied either preplant incorporated (PPI) or preemergence (PRE). Early postemergence (EPOST) applications varied according to weather conditions and peanut growth at each location. Postemergence (POST) treatments were applied 26 to 58 days after planting. Weed control and peanut stunting were visually estimated on a scale of 0 to 100 (0 indicating no control or plant death and 100 indicating complete control or plant death).
Results: Peanut stunting with C + P was only noted at the High Plains and Oklahoma locations in 2015 but not 2016. Urochloa texana (Buckl.) control with C + P (PRE) varied from 75 to 93%. POST applications provided inconsistent control. Amaranthus palmeri S. Wats. control with C + P (PRE) was at least 78% season-long while POST applications were inconsistent (24 to 100%). Pendimethalin plus C + P controlled Cucumis melo L. var. Dudaim Naud. at least 80% late-season. Ipomoea hederacea Jacq. control was excellent season-long (> 80%) in 2015 but poor (< 60%) in 2016. Reduced peanut yields were noted with C + P in Oklahoma in 2015 to excessive season-long injury.
Conclusion: The premix of C + P has potential for use in peanut especially for control of many small-seeded annual broadleaf weeds that continue to plague many peanut growers across the southwest. For effective broad-spectrum annual weed control season-long, the addition of pendimethalin to PRE applications will be required.
Relationship between Attitude and Anxiety Related to Online Learning
Authors: Kumari Darshana , Besekar Swity , Wadsariya Karishma , Ughade Minal , Utkhede Aditya , Wankhede Pranay 
Published: November 2021

Background: Online learning is not newest but recently fresh used mode in educational sector where it was difficult for every student to adopt it. Initially students were having a different attitude towards online learning and they were anxious about there academic curriculum. The study was conducted to assess their attitude and anxiety towards online classes and to see the correlation between attitude and anxiety of online learning. We know mid school student has good adaptation ability but then also it’s a very new for them where students were facing lots of problem and faced lots of challenges due to COVID-19 pandemic specially the student who belong to poor family, but in this difficult time, everyone is doing their best to acquire new skills, and it's getting easier to enroll in online classes and finish their academic sessions.
Objective: 1. To assess the attitude and anxiety of online learning among students. 2. To correlate the attitude and anxiety of online learning among students.
Methods: This study was based on a Quantitative research approach. Convenient sampling technique was used. The population was all mid-school students from selected school area consisted of 200 samples. And there was structured attitude and general anxiety scale were used.
Results: The mid study shows positive attitude and mild anxiety where the correlation between the attitude and anxiety is negative as per analysis.
“Prevalence and Source of Various Types of Workplace Violence among Healthcare Professionals in the Public Hospitals of Karachi” A Cross-Sectional Survey
Authors: Maheshwari Jai Dev , Zaheer Sidra , Maheshwari Greesh Kumar , Khan Kiran , Batool Syeda , Turab Syed Mohsin 
Published: November 2021

Objectives: To determine the prevalence of violence among medical doctors in public sector hospitals of Karachi relating to physical violence, psychological violence (verbal and bullying/mobbing), sexual harassment and racial harassment).
Methods: A cross-sectional study was carried out in three public sector hospitals in Karachi (JPMC, Civil Hospital and Sindh Government Lyari General Hospital Karachi). Medical doctors of any age and gender who worked in outpatient departments, wards, and emergency departments were eligible to participate in the study. A validated WHO-designed questionnaire was used, with questions about exposure to violence, the source and types of violence, and socio-demographic information. In descriptive statistics, frequencies and percentages were reported for all categorical variables. The Chi-square and Fisher's exact tests were used to investigate the relationship between workplace violence and other types of violence.
Results: 350 questionnaires were distributed to qualified medical doctors in total. Only 300 of them responded, for an 85.7 percent response rate. The majority of respondents were under the age of 40, and male gender was slightly more exposed to violence. The majority of the doctors were subjected to verbal abuse as well as bullying and mobbing.
Conclusion: It was then concluded that any type of violence was common in doctors aged >35 years and male gender was more exposed to any violence as compare to female gander. The main type of violence was verbal violence in our study, whereas racial harassment and sexual harassment was also seen.
To Assess the Knowledge and Providing Booklet Regarding Health Hazards of Spitting in Public Places among General Population
Authors: Wankhede Darshana Kumari , Ghugare Suwarna , Zade Nikita V. , Bansod Payal C. , Kamdi Khushbu K. , Dewale Nutan R. 
Published: November 2021

Background: Smokeless tobacco consumption, which is widespread throughout the world, lead to oral sub mucous fibrosis (OSMF), which is a long-lasting and disturbing condition of the oral cavity with the potential for malignancy. Mainly focus on the consumption of smokeless tobacco, such as pan and ghutkha the role of these substances in the instruction of OSMF and ultimately oral cancer. It was established using the finding tools provide. The continuous chewing pan and swallowing of ghutkha cause progressive fibrosis in sub mucosal tissue. Generally, OSMF occurs due to multiple risk factors, especially smokeless tobacco and its mechanism, such as betel quid, Areca nuts, and slaked lime, which are used in pan and gutkha. The incidence of oral cancer is higher in women than in men in the South Asian country.
Objective: 1 To assess the existing knowledge regarding health hazards of spitting in public places among the general population. 2. To develop Information booklet regarding health hazards of spitting in public places among the general population.
Material and Method:
Research Design: Pre experimental research design,
Research Approach: Survey approach,
Setting of Study: Rural population Sawangi (Meghe) Wardha district,
Sample: The sample for the present study comprised of 100,
Sample size: The sample size selected for this study was 100 sample,
Sampling Technique: A convenience sampling technique.
Result: After the complete analysis, this study lead to the following result that the mean knowledge score in pre-test was 6.61±2.30 and in post test it was 11.68±1.45 and mean percentage of knowledge score in pre test was 44.06±15.33 and in post test it was 77.86±9.70.
Conclusion: After the conclusion of the study it is exposed that the most of the knowledge are gained by providing the booklet and it is most effective result are occurred to provide the same information about the splitting.
Collagen-Chitosan Composite Powder as a Novel Biomaterial for Chronic Wounds in Hansen Disease-A Clinical Study
Authors: Babu Pombala Suresh , Srinivasan Harini , Dhandapani B. Sai , Rose C. 
Published: November 2021

Aims: Natural biomaterials are more suitable than synthetic biomaterials for in vivo applications for treating damaged tissues. Collagen and chitosan are abundantly available natural biomaterials for wound dressings for tissue/wound repair. In this context, collagen-chitosan composite powder has been used to treat chronic wounds in Hansen disease (HD) patients.
Place and Duration of Study: CSIR Central Leather Research Institute, Sardar Patel Road, Adyar, Chennai 600021, Southern Railway Headquarters Hospital, Constable Road, Ayanavaram, Chennai 600023, and Gremaltes Hospital, India between June 2013 and July 2020.
Methodology: Collagen extracted from bovine rumen, a waste product of meat industry, and a commercially available chitosan were prepared as a composite powder (COL/CS) and applied to chronic wounds in HD patients after debridement and the wound contours were measured by planimetry. Biochemical parameters in blood samples were periodically assessed. Histopathology of wound tissue with Hematoxylin and Eosin and Masson’s Trichrome staining was studied. Matrix Metalloproteinase-9 (MMP9) levels before and after treatment were estimated.
Results: Wound healing of 64.2% was obtained with COL/CS treatment and formation of granulation cells was observed early. Hemogram studies have been reported in a regression model with 95% confidence intervals. Histopathology revealed dense collagen fibres and continuity of sub-epithelial layer on 8th day. MMP-9 levels showed collagen integrity after treatment.
Conclusion: The novel biocompatible, biodegradable COL/CS wound dressing is a promising biomaterial for management of chronic wounds in Hansen disease patients.
Localised Aggressive Periodontitis – A Review
Authors: Wasnik Milind , Kumar Suryakant , Sajjanar Arun , Gahlod Niharika , Khekade Sneha , George Miranda , Bhattad Durga , Kolekar Pratima 
Published: November 2021

The term “periodontal diseases” includes any inherited or acquired disorders of the tissues that are supporting the teeth i. e Gingiva, Cementum, PDL, and Alveolar bone. The periodontal disease can be either localized or generalized. Localized aggressive periodontitis (LAgP) patients have interproximal attachment loss on at least two permanent first molars and incisors, with attachment loss on no more than two teeth other than first molars and incisors. In children and adolescents LAgP occurs without clinical evidence of systemic disease and it is characterized by the severe loss of alveolar bone around permanent teeth [10]. Most commonly the disease is localized to the permanent first molars and incisors.
Aim: The aim of this review article is explain in details about aggressive periodontitis including different management aspect of the same.
Methods: This paper presents a review of the aggressive periodontitis in children. An electronic search was conducted using Pub Med®/MEDLINE, and Google search using the terms: Periodontium, Localized Aggressive Periodontitis, Children and periodontal health, periodontal health in adolescents, gingival disease in children, periodontal disease in children, gingivitis, periodontitis, gingival disease and its prevalence, periodontal disease and its prevalence.
Analytical Profile of an Unparalleled Drug Tinospora crispa W.R.T Guduchi
Authors: Lekshmipriya S. , Pandya M. R. , Prajapati Bijal 
Published: November 2021

Introduction: Guduchi is a highly potential drug which is mentioned in Ayurveda classics. The clinical utility of this drug is widely known. The Tinospora species are wrapped under the broad spectrum Guduchiin the Ayurveda classics. Tinospora is one of the important genera of the family, consisting of about 15 species. Some medicinally important species includes T. cordifolia, T. malabarica, T. tomentosa, T. crispa, T. uliginosa, T. crispaetc. In the current article the drug Tinospora crispa is considered in detail.Tinospora crispa is used irrationally by the society owing to its various therapeutic benefits. Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae), found in the rainforests or mixed deciduous forests in Asia and Africa, is used in traditional medicines to treat numerous health conditions.
Materials & Methods: A detailed review of the drug has been carried out through the available literature. After considering the review the analytical profiling of the drug has been done.The phytochemical analyses review of T. crispa revealed the presence of alkaloids, flavonoids, and flavone glycosides, triterpenes, diterpenes and diterpene glycosides, cis clerodane-type furanoditerpenoids, lactones, sterols, lignans, and nucleosides. The literary review showed that the crude extracts and isolated compounds of T. crispa possessed a broad range of pharmacological activities such as anti-inflammatory, antioxidant, immunomodulatory, cytotoxic, antimalarial, cardioprotective, and anti-diabetic activities.So, in the current research study a sincere attempt has been made to study regarding the drug Tinospora crispa through its analytical profile.
Results: Through this research article able to make out the available literature and the analytical profile of the drug Tinospora crispa.
Discussion: The current analytical profile reveals the presence of alkaloids, tannins, flavonoids, saponins etc which directly connects to the various activities like Anti-pyretic, Anti- inflammatory, Antioxidant etc of the drug Tinospora crispa.
Conclusion: The current research study points towards the review of the drug and the analytical profile which is beneficial to carry out the next phase of research studies in connection with this drug Tinospora crispa.
Health Care Professionals’ Quality of Life during COVID-19 Pandemic
Authors: J. Ahmed Nehad , Z. Alkhawaja Faisal , K. Alghazwani Mohammed , A. Menshawy Menshawy 
Published: November 2021

Aim: The present study aimed to describe health care professionals’ quality of life during COVID-19 pandemic Saudi Arabia.
Methodology: The cross-sectional study included a survey that was prepared using the world health organization quality of life assessment instrument (WHOQOL). To provide a good quality of care and to achieve patient satisfaction on the care received, it is important to know how satisfied health care personnel are with their quality of life and job because the personnel with a good quality of life offer better services than those with poor quality of life.
Results: The present study showed that the quality of life of about two third of the health care providers was good. Nonetheless, about one third of them had a poor quality of life.
Conclusion: There is a need to implement long term programs aimed at improving the emotional well-being of health care specialists and improving their quality of life.
Assessment Swot on Performance of Micronized Itraconazole against Candida albicans and Aspergillus niger for Superior Health Security
Authors: Venugopal N. V. S. , Reddy K. Bujji 
Published: November 2021

Background: Antifungal medication is used in adults to indulge infections caused by fungi. This includes infections in any part of the body including the lungs, mouth or throat, toenails, or fingernails. The widespread fungal pathogens causing stern insidious infections surrounded by immuno compromised patients are Candida albicans and Aspergillus niger. Itraconazole, is an antifungal medication used to treat a number of fungal infections. Itraconazole undergoes rapid metabolism to form hydroxyitraconazole, which also contributes to the anti-fungal activity exhibited by the parent compound. In the present study the assessment of plain Itraconazole and micronized Itraconazole material for increasing health safety and its biological evaluation by using Candida albicans and Aspergillus niger was reported.
Methods: The determination of particle size of the micronized material which is a very fine powder and its characteristics was carried out by Dynamic light scattering(DLS) and Scanning Electron Microscopy(SEM).Structural identification was done by UV-spectroscopy and Fourier transform Infrared spectroscopy(FT-IR).
Results: An active pharma ingredient having antifungal activity was selected and micronized using Microniser to reduce the particle size as small as possible. The product antifungal activity was reviewed between untreated material(large particle size, 200 microns) and reduced particle size(micro particles, 2.72 microns). Size reduction showed an increased efficiency of antifungal activity
Conclusion: The antifungal activity of Itraconazole can be enhanced if the coarse large particles are micronized to significantly (>70 folds) smaller particles.
Covalent‐Linking‐Enabled Superior Compatibility of ZIF‐8 Hybrid Membrane for Efficient Propylene Separation
Authors: Wang Ziyang , Wang Wenjian , Zeng Tao , Ma Dan , Zhang Panpan , Zhao Siqi , Yang Li , Zou Xiaoqin , Zhu Guangshan 
Published: November 2021

AbstractThe interface is a critical issue for metal–organic‐framework hybrid membranes in propylene separation. Here, a covalent‐linking strategy is reported for strikingly reinforcing the interfacial compatibility in a ZIF‐8‐based membrane. A functionalized ZIF‐8 material named ZIF‐8‐CN is synthesized using the mixed‐ligand approach. ZIF‐8‐CN has an identical crystalline structure to ZIF‐8, and the 4,5‐dicyanoimidazole ligand is available for further functionalization. Covalent linkage of ZIF‐8‐CN with PIM‐1 is driven by the thermal reaction of the cyano groups on both entities, which strengthens the filler–polymer connection in the ZIF‐8‐CN@tPIM‐1 membrane. ZIF‐8‐CN@tPIM‐1 exhibits remarkably enhanced propylene permeation property with C3H6/C3H8 selectivity of ≈28, which is 350% and 180% higher than those on non‐treated ZIF‐8‐CN/PIM‐1 and non‐functionalized ZIF‐8@tPIM‐1, respectively. Additionally, ZIF‐8‐CN@tPIM‐1 shows the highest C3H6 permeability of ≈370 Barrer among all relevant ZIF‐8 membranes. This strategy opens an avenue for precise interface engineering in membranes and the resultant high performance is appealing in the propylene separation industry.
Electrostatic–Mechanical Synergistic In Situ Multiscale Tissue Adhesion for Sustainable Residue‐Free Bioelectronics Interfaces
Authors: Kim Da Wan , Song Kang‐Il , Seong Duhwan , Lee Yeon Soo , Baik Sangyul , Song Jin Ho , Lee Heon Joon , Son Donghee , Pang Changhyun 
Published: November 2021

AbstractRecent studies on soft adhesives have sought to deeply understand how their chemical or mechanical structures interact strongly with living tissues. The aim is to optimally address the unmet needs of patients with acute or chronic diseases. Synergistic adhesion involving both electrostatic (hydrogen bonds) and mechanical interactions (capillarity‐assisted suction stress) seems to be effective in overcoming the challenges associated with long‐term unstable coupling to tissues. Here, an electrostatically and mechanically synergistic mechanism of residue‐free, sustainable, in situ tissue adhesion by implementing hybrid multiscale architectonics. To deduce the mechanism, a thermodynamic model based on a tailored multiscale combinatory adhesive is proposed. The model supports the experimental results that the thermodynamically controlled swelling of the nanoporous hydrogel embedded in the hierarchical elastomeric structure enhances biofluid‐insensitive, sustainable, in situ adhesion to diverse soft, slippery, and wet organ surfaces, as well as clean detachment in the peeling direction. Based on the robust tissue adhesion capability, universal reliable measurements of electrophysiological signals generated by various tissues, ranging from rodent sciatic nerve, the muscle, brain, and human skin, are successfully demonstrated.
Tailoring Aggregation Extent of Photosensitizers to Boost Phototherapy Potency for Eliciting Systemic Antitumor Immunity
Authors: Zhao Hao , Xu Jiabao , Feng Chan , Ren Jiayu , Bao Lin , Zhao Yanbing , Tao Wei , Zhao Yuliang , Yang Xiangliang 
Published: November 2021

AbstractPhototherapy is effective for triggering the immunogenic cell death (ICD) effect. However, its efficacy is limited by low 1O2 generation and photothermal conversion efficacy due to two irreconcilable obstacles, namely the aggregation‐caused‐quenching (ACQ) effect and photobleaching. In this work, a discretely integrated nanofabrication (DIN) platform (Pt‐ICG/PES) is developed by facile coordination coassembly of cisplatin (Pt), photosensitizer molecules (indocyanine green (ICG)), and polymeric spacer (p(MEO2MA‐co‐OEGMA)‐b‐pSS (PES)). By controlling the ICG/PES feeding ratio, the aggregation of ICG can be easily tailored using PES as an isolator to balance the ACQ effect and photobleaching, thereby maximizing the phototherapy potency of Pt‐ICG/PES. With the optimized ratio of each component, Pt‐ICG/PES integrates the complementarity of photodynamic therapy, photothermal therapy, and chemotherapeutics to magnify the ICD effect, exerting a synergistic antitumor immunity‐promoting effect. Additionally, temperature‐sensitive PES enables photothermally guided drug delivery. In a tumor‐bearing mouse model, Pt‐ICG/PES elicits effective release of danger‐associated molecular patterns, dendritic cell maturation, cytotoxic T lymphocytes activation, cytokine secretion, M2 macrophage repolarization, and distal tumor suppression, confirming the excellent in situ tumor ICD effect as well as robust systematic antitumor immunity. Ultimately, a versatile DIN strategy is developed to optimize the phototherapeutic efficacy for improving antitumor effects and strengthening systemic antitumor immunity.