bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder
Authors: Le Vanessa , Kirsch Dylan E. , Tretyak Valeria , Weber Wade , Strakowski Stephen M. , Lippard Elizabeth T. C. 
Published: November 2021

Background: Psychosocial stress negatively affects the clinical course of bipolar disorder. Studies primarily focused on adults with bipolar disorder suggest the impact of stress is progressive, i.e., stress response sensitizes with age. Neural mechanisms underlying stress sensitization are unknown. As stress-related mechanisms contribute to alcohol/substance use disorders, variation in stress response in youth with bipolar disorder may contribute to development of co-occurring alcohol/substance use disorders. This study investigated relations between psychosocial stress, amygdala reactivity, and alcohol and cannabis use in youth with bipolar disorder, compared to typically developing youth.Methods: Forty-two adolescents/young adults [19 with bipolar disorder, 23 typically developing, 71% female, agemean ± SD = 21 ± 2 years] completed the Perceived Stress Scale (PSS), Daily Drinking Questionnaire modified for heaviest drinking week, and a modified Montreal Imaging Stress functional MRI Task. Amygdala activation was measured for both the control and stress conditions. Main effects of group, condition, total PSS, and their interactions on amygdala activation were modeled. Relationships between amygdala response to acute stress with recent alcohol/cannabis use were investigated.Results: Greater perceived stress related to increased right amygdala activation in response to the stress, compared to control, condition in bipolar disorder, but not in typically developing youth (group × condition × PSS interaction, p = 0.02). Greater amygdala reactivity to acute stress correlated with greater quantity and frequency of alcohol use and frequency of cannabis use in bipolar disorder.Conclusion: Recent perceived stress is associated with changes in amygdala activation during acute stress with amygdala reactivity related to alcohol/cannabis use in youth with bipolar disorder.
Using a Co-design Approach to Create Tools to Facilitate Physical Activity in Children With Physical Disabilities
Authors: Bolster Eline A. M. , Gessel Christa van , Welten Maxime , Hermsen Sander , Lugt Remko van der , Kotte Elles , Essen Anita van , Bloemen Manon A. T. 
Published: November 2021

Introduction: There is a lack of effective interventions available for Pediatric Physical Therapists (PPTs) to promote a physically active lifestyle in children with physical disabilities. Participatory design methods (co-design) may be helpful in generating insights and developing intervention prototypes for facilitating a physically active lifestyle in children with physical disabilities (6–12 years).Materials and methods: A multidisciplinary development team of designers, developers, and researchers engaged in a co-design process–together with parents, PPTs, and other relevant stakeholders (such as the Dutch Association of PPTs and care sports connectors). In this design process, the team developed prototypes for interventions during three co-creation sessions, four one-week design sprint, living-lab testing and two triangulation sessions. All available co-design data was structured and analyzed by three researchers independently resulting in themes for facilitating physical activity.Results: The data rendered two specific outcomes, (1) knowledge cards containing the insights collected during the co-design process, and (2) eleven intervention prototypes. Based on the generated insights, the following factors seem important when facilitating a physically active lifestyle: a) stimulating self-efficacy; b) stimulating autonomy; c) focusing on possibilities; d) focusing on the needs of the individual child; e) collaborating with stakeholders; f) connecting with a child's environment; and g) meaningful goal setting.Conclusion: This study shows how a co-design process can be successfully applied to generate insights and develop interventions in pediatric rehabilitation. The designed prototypes facilitate the incorporation of behavioral change techniques into pediatric rehabilitation and offer new opportunities to facilitate a physically active lifestyle in children with physical disabilities by PPTs. While promising, further studies should examine the feasibility and effectivity of these prototypes.
Late-Onset Ileocutaneous Fistula Eight Years After Plug Repair With Polypropylene Mesh: A Case Report
Authors: Zhang Jiankang , Hu Zeming , Lin Xuan , Chen Bin 
Published: November 2021

Introduction: As one of the short-term complications after inguinal hernia repair, mesh infection frequently occurs but rarely leads to ileocutaneous fistula. We present a rare case of ileocutaneous fistula 8 years after inguinal hernia plug repair with polypropylene mesh.Case Presentation: The patient was a 67-year-old male who underwent a plug repair with polypropylene mesh of the right inguinal hernia. Eight years after the primary repair, skin ulceration with pus presented in the right groin area, and the final diagnosis was enterocutaneous fistula. According to laparoscopic exploration, the ileum below the fistula closely adhered to the abdominal wall. After gently separating the bowel loop, a defect area of about 2 × 3 cm was observed on the surface of the ileum. In laparotomy, the plug was found embedded in the ileum and then was completely removed, and an ileum side-to-side anastomosis was performed. The patient was discharged 2 weeks after the surgery, and follow-up at the sixth month revealed complete healing of the wound and no evidence of hernia recurrence.Conclusion: Late-onset ileocutaneous fistula should be considered in the differential diagnosis in patients who present inflammation and abscess formation after hernia repair. Besides, for patients with suspected intestinal fistula after hernia repair, laparoscopic exploration should be given priority, and the mesh removal approach should be tailored according to the results of laparoscopic exploration.
Effect of Cannabis Smoke Condensate on C. albicans Growth and Biofilm Formation
Authors: Tazi Neftaha , Pigeon Xavier , Mbuyi-Boisvert Jérôme Mulamba , Giret Simon , Béland François , Rouabhia Mahmoud 
Published: November 2021

The most common use of cannabis is smoking. The oral ecosystem, among other constituents, can be deregulated by the presence of cannabis smoke in the oral cavity. We evaluated the effect of cannabis smoke condensate (CSC) on the behavior of Candida albicans, a common yeast found in the oral cavity. The yeast was first cultured with different concentrations of CSC, and its growth was evaluated. The transition from the blastospore to the hyphal form and the hyphae size were assessed after 3 and 6 h, along with biofilm formation after 72 h of contact with CSC. The response of C. albicans to oxidative (H2O2) stress was also examined. Our results show that CSC contained high amounts of THC (about 1055 ppm), CBN (63 ppm), and CBG (about 47 ppm). The presence of various concentrations of CSC in the culture medium increased C. albicans growth. CSC also contributed to increases in both the hyphal length and biofilm mass. Following oxidative stress (H2O2 at either 100 or 500 μM), CSC prevented the damaging effect of H2O2 on both C. albicans shape and growth. These findings support clinical observations demonstrating that cannabis may promote C. albicans growth and oral candidiasis.
Problematika dan Strategi Pembelajaran pada Masa Pandemi di Wilayah Pesisir Kepulauan Buton
Authors: Mansyur Firman Alamsyah , Taharu Fahmil Ikhsan 
Published: November 2021

This study aims to explain the problems and strategies of schools and teachers in coastal areas of the Buton islands in carrying out learning during the Covid-19 pandemic. This research method is descriptive qualitative. Primary data are collected through online questionnaires, observations, and interviews. Research informants come from the elements of teachers, high school principals, students and parents of participants, especially Muhammadiyah High School. Secondary data is obtained through literature studies. The data are analyzed using qualitative data analysis method consisting of data reduction, data presentation, data interpretation and conclusion drawing. From the results of the study, it is concluded that there are various problems in the implementation of learning in high schools during the pandemic-Covid-19. The problems are strongly related to the unpreparedness of schools, teachers, parents, and students in facing the transformation of learning during the pandemic. In addition, network unpreparedness also greatly affects the transformation of learning from offline to online to ineffective. Therefore, there are various strategies that schools and teachers try to implement to carry out learning, both online and face-to-face through limited class meetings and home visits. The results of this study show that the implementation of learning during the pandemic does not run effectively due to very complex problems. The role of the government is very important in preparing facilities and infrastructure to support the implementation of learning during the pandemic covid-19.
FACTORES ASOCIADOS A MORTALIDAD POR NEUMONIA EN UN HOSPITAL DE TERCER NIVEL DE COLOMBIA
Authors: Machado-Alba Jorge Enrique , Isaza-Martinez Berenice , Sepulveda-Marin Monica 
Published: November 2021

Objetivos: Determinar las variables asociadas con mortalidad por Neumonía Adquirida en la Comunidad (NAC) en hospital de Colombia
Materiales y métodos: Estudio de corte transversal en pacientes mayores de 14 años con diagnóstico de NAC entre 1 enero 2010 y 30 marzo 2012. Se consideraron variables socio-demográficas, clínicas, paraclínicas y terapéuticas. Se hicieron análisis bivariados y multivariados con paquete estadístico SPSS-20.0
Resultados: De 297 casos con NAC, hubo predominio masculino (53,5%), edad promedio 56,3±22,4 años. El 22,6% de los casos murieron. Las variables ausencia de dolor pleurítico (OR:0,10; IC95%:0,040-0,292, p
Use of a Mobile Health (mHealth) Platform for Remote Assessment of Suicidal Ideation, Depression, and Anxiety: A Longitudinal Retrospective Study
Authors: Pardes Adam , Lynch William , Miclette Matthew , McGeoch Ellen , Daly Brian P 
Published: November 2021

ABSTRACT

Introduction
There is growing support for the use of integrated measurement-based care to capture symptom data in real time so treatment providers can make informed decisions about intervention strategies for mental health problems, such as depression and anxiety, both of which are known to increase suicide. We examined the potential scalability and effectiveness of a mobile health (mHealth) application with integrated behavioral health functions to capture remote patient-reported measurement of suicidal ideation and overall symptoms of depression and anxiety.

Methods
This study was an observational retrospective review of deidentified patient data, including symptoms of suicidal ideation, depression, and anxiety as measured by the Patient Health Questionnaire-9 (PHQ-9) or Generalized Anxiety Disorder 7 (GAD-7) scale, which were administered to and completed by patients on a smartphone or desktop application. After controlling for age, sex, and the presence of moderate versus severe symptoms at baseline, mean scores were analyzed with the Student's t-test.

Results
Of patients who took the PHQ-9 assessment at baseline and 8 weeks later (n = 764), the proportion who endorsed suicidal thinking decreased from 25% to 14.66% (p &lt; 0.001) over 8 weeks. The mean PHQ-9 score was reduced from 14.69 (standard error [SE], 4.09) to 10.50 (SE, 5.94; p &lt; 0.001), and a subset of individuals who continued use and took the PHQ-9 again at 24 weeks (n = 185) had a further decrease to 9.03 (SE, 7.09, p &lt; 0.01). Although 21.62% of this subset still had suicidal thinking, the frequency of suicidal thoughts decreased. Of patients who took the GAD-7 at baseline and 8 weeks (n = 797) the mean score decreased from 14.20 (SE, 3.31) to 10.08 (SE, 5.55; p &lt; 0.001) at 8 weeks and to 7.48 (SE, 6.54; p &lt; 0.001) for a subset (n = 278) who continued use and took a GAD-7 at 24 weeks (n = 278). The sum of subgroup samples is larger than the whole because of instances of comorbid depression and anxiety.

Conclusion
Remote assessments within technology-supported integrated behavioral health care were feasible at scale. Change in symptoms could be observed at the individual and group level in real time, which may allow clinical teams to adjust treatments and improve outcomes. Prospective controlled studies are needed to determine what factors contribute to reductions in symptom severity.
IMPLEMENTASI MODEL PEMBELAJARAN DARING PADA MASA PANDEMI COVID – 19
Authors: Harmawati  , Tia Latifatu Sa’diah  , Nadiya Angraeni  
Published: November 2021

Penelitian ini merupakan penelitian kualitatif deskriptif. Penelitian ini dilaksanakan di Sekolah Dasar Negeri Cengkong II Kecamatan Purwasari kabupaten Karawang. Subjek penelitian ini adalah 3 orang yaitu guru kelas IV, 1 orang siswa dan 1 orangtua siswa. Objek penelitian ini adalah proses pembelajaran daring pada masa covid-19. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah pengamatan dan wawancara. Instrumen pengumpulan data terdiri atas pengamatan dan pedoman wawancara. Analisis data dilakukan secara deskriptif dengan melakukan Teknik analisis data model Miles and Humberman.
Hasil dari pengamatan dan wawancara diperoleh bahwa Sekolah Dasar Negeri Cengkong II Kecamatan Purwasari Kabupaten Karawang pada masa pandemi covid-19 melakukan pembelajaran jarak jauh (PJJ) dengan menggunakan model pembelajaran daring / online. Aplikasi whatsapp, google meet, google form, zoom dan kine master adalah aplikasi yang digunakan dalam proses pembelajaran daring / online. Handphone, kuota dan jaringan internet yang kuat dan stabil merupakan faktor utama dalam proses pembelajaran daring / online, agar tercapainya materi ajar dan tujuan pembelajaran selama guru menjelaskan dan menyampaikan materi yang telah disiapkan. Selain itu terdapat kendala dalam proses pembelajaran daring yaitu: jaringan internet yang tidak stabil dan tidak semua siswa memiliki handphone / gadget.
Kata kunci : Implementasi pembelajaran, model pembelajaran daring / online.
This research is a descriptive qualitative research. This research was conducted at Cengkong II State Elementary School, Purwasari District, Karawang Regency. The subjects of this study were 3 people, namely the fourth grade teacher, 1 student and 1 student's parent. The object of this research is the online learning process during the covid-19 period. Data collection techniques used in this study were observation and interviews. The data collection instrument consisted of observations and interview guidelines. Data analysis was carried out descriptively by using the Miles and Humberman model data analysis technique.
The results from observations and interviews showed that the Cengkong II State Elementary School, Purwasari District, Karawang Regency during the covid-19 pandemic carried out distance learning (PJJ) using an online / online learning model. WhatsApp, Google Meet, Google Form, Zoom and Kine Master applications are applications that are used in the online learning process. Mobile phones, quotas and a strong and stable internet network are the main factors in the online learning process, in order to achieve teaching materials and learning objectives as long as the teacher explains and conveys the material that has been prepared. In addition, there are obstacles in the online learning process, namely: unstable internet network and not all students have cellphones / gadgets.
Keywords: Implementation of learning, online learning model / online.
Може ли да очакваме централизирано договаряне на достъп до лекарства сираци в ЕС?
Authors: Искров Георги , Стефанов Румен 
Published: November 2021

Точно преди година – на 25 ноември 2020 г. – беше приета действащата Фармацевтична стратегия за Европа. Основна цел на този документ е създаването на надеждна и устойчива регулаторна рамка, която, от една страна, да отговори на очакванията и потребностите на европейските пациенти, а от друга – да насърчи иновацията и модернизацията във фармацевтичния сектор. При финализирането на стратегията бяха отчетени и редица слабости, разкрити по време на настоящата пандемия от COVID-19.
Фармацевтична стратегия за Европа стъпва на 4 основни стълба, които предвиждат както законодателни мерки, така и незаконодателни действия: осигуряване на лекарствени продукти на достъпни цени за пациентите и отговаряне на неудовлетворени медицински потребности; подкрепа на конкурентоспособността, иновациите и устойчивостта на фармацевтичната индустрия на ЕС и разработване на висококачествени, безопасни и ефективни лекарствени продукти; повишаване на готовността при кризи и оптимизиране на механизмите за реагиране, гарантиране на диверсифицирани и сигурни вериги за доставки, справяне с недостига на лекарствени продукти; засилване на ролята на ЕС в света чрез насърчаване на високо ниво на стандарти за качество, ефикасност и безопасност. Какво предстои от тук нататък?
Кардиомиопатия при пациент с мускулна дистрофия тип Дюшен
Authors: Панчева Ралица , Стоименов Благовест 
Published: November 2021

Мускулната дистрофия тип Дюшен (МДД) е генетично, невромускулно заболяване, което се характеризира с прогресивно засягане на скелетната мускулатура, като впоследствие се развиват и белодробна и сърдечна дисфункция. Сърдечната недостатъчност (СН) е основна причина за смъртта на тези пациенти. Ранното откриване на сърдечното засягане често е предизвикателство, дължащо се на дългата субклинична фаза на камерна дисфункция и затруднения при оценката на сърдечно-съдовата симптоматика при тези пациенти, които обикновено губят възможността за движение в ранно юношество. Ранната диагностика на сърдечното засягане при пациенти с МДД обаче е решаваща, тъй като позволява навременно започване на кардиопротективни терапии, които могат да смекчат симптомите на СН и да забавят патологичното ремоделиране на сърдечния мускул. Редовното сърдечно-съдово проследяване е от решаващо значение при лечението на МДД. Ранното разпознаване и профилактичното използване на инхибитори на ангиотензин конвертиращия ензим са основната терапевтична стратегия за забавяне на честотата на обусловената от МДД дилатативна кардиомиопатия (ДКМП). Поради липсата на специфична за МДД терапия, настоящата стратегия за лечение е съгласно препоръките за поведение при хронична СН.
Представяме рядък и интересен клиничен случай, за да подчертаем значимостта на това усложнение на болестта, което води до лоша прогноза и изисква своевременно започване на кардиопротективна терапия.
Intellectual property in the digital space
Authors: IZBASH O. 
Published: November 2021

The article examines the modern view of art in the digital space and the regulation of intellectual property in connection with this phenomenon. The author reveals the concept of blockchain and non-fungible token, their development and impact on the rights of creators. There are many challenges for digital artists today. One of them is that digital art objects can be easily copied as many times as you want. Yes, many will say that you can just save a picture and such saved copies would not differ from the original. But there is one nuance, or rather the opportunity provided by NFT – it’s the right to own the original version of the work. It is like having an original painting on display at the Louvre, and other reproductions and copies outside it will only promote and increase the value of this work, as it will become more recognizable. Therefore, NFT allows you to capture your intellectual property rights, which are confirmed in the blockchain. The use of NFT can be a new tool in the field of intellectual property management, creating new opportunities for the market and its participants, making it more convenient, because transactions with tokens are cheap, simple and faster than transactions with real objects to which they are tied. It is worth noting that the hype surrounding the use of NFT does not revolutionize art, computer games, or intellectual property itself, but it does offer significant new opportunities that deserve attention.
The role of profiling of drugs, psychotropic substances and precursors in combating their illegal trafficking
Authors: KUCHYNSKA I. 
Published: November 2021

Recently, there is a negative trend in the world – increasing number of synthetic drugs, psychotropic substances and precursors in the illicit trafficking of these substances. Specially equipped underground laboratories for their drug production are being set up to meet the demand for synthetic drugs. Synthetic drugs and psychotropic substances produced in underground laboratories can be synthesized in various ways. Various precursors and reagents are used for their synthesis, which leads to the appearance of impurities in the final product. Impurities help to determine the ways of synthesis of the illegal substance, the origin of the precursors, provide information about the location of production. Due to the presence of impurities, the connections between the removed substances are revealed. Specific impurities are used to determine the route of production, which, combined with other forms of investigation, will help to link different batches of a prohibited substance to the specific person who manufactured them. Impurities associated with the synthesis of substances seized in illegal laboratories are so-called marker compounds. They are a kind of marks that guide the expert chemist on the specific method used by criminals to obtain the substance. Marker compounds are of the greatest importance for the accurate establishment of the synthesis method. Marker compounds are determined by impurity profiling of samples of the prohibited substance. The main purpose of the profiling of impurities is to assist law enforcement agencies in combating the illicit manufacture and circulation of controlled substances. The results of research and information on the circumstances of the confiscation should be recorded in the relevant created electronic databases. In the profile database, two samples of a substance with a similar chemical profile can be linked together from the manufacturing stage to the distribution stage. Data on impurity profiles and fillers can be used to estimate the batch size, time and area of drug distribution. Databases are needed for use by law enforcement agencies in operational and investigative work. Databases are needed for the timely detection and liquidation of underground drug laboratories. The above aspects emphasize the importance of cooperation between investigative, operational services and forensic agencies in the process of effective detection and cessation of crimes related to the distribution of controlled substances.
Legal aspects of registration and accounting of research and development works in the field of state national security
Authors: ALEKSEIEVA O. 
Published: November 2021

The article is devoted to the issues of registration and accounting of research and development work performed in the field of national security, by the example of the Ukrainian scientific and research Institute of special equipment and forensic expertise of the Security Service of Ukraine. The legal bases for actions on the specified subjects are investigated. The current state of affairs on the raised issue is analyzed. Some issues that arise during the registration procedure are highlighted.