bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of FIB-4 for reassessment of hepatic fibrosis burden in referral center
Authors: Roh Yun Hwa , Kang Bo-Kyeong , Jun Dae Won , Lee Chul-min , Kim Mimi 
Published: June 2021

AbstractLow cut-off of FIB-4 is a widely used formula to exclude advanced liver fibrosis in primary care centers. However, the range of reported threshold of FIB-4 to rule in advanced fibrosis is too broad across etiologies, and no consensus has been reached. In the present study, we investigated the role of FIB-4 for a reassessment of hepatic fibrosis burden in a referral center. We compared the diagnostic performance of FIB-4 among patients with liver disease of various causes and tried to find an optimal cut-off value for predicting advanced fibrosis. Among 1068 patients, the AUROC of FIB-4 to diagnose advanced fibrosis showed no significant difference among the various etiologies of liver disease, ranging from 0.783 to 0.821. The optimal cut-off value obtained by maximizing Youden's index was 2.68, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for predicting advanced fibrosis were 70.7%, 79.1%, 43.5%, and 92.2%, respectively. The PPV was low in patients with autoimmune disease (6.67%). When we incorporated the new cut-off of FIB-4 into abdominal ultrasound findings, 81% of unnecessary work-ups would be appropriately avoided. In conclusion, the cut-off value of 2.68 showed an acceptable PPV while maintaining a high NPV to predict advanced fibrosis, most etiology except for autoimmune diseases. This result could assist in establishing an appropriate timing to reassess the hepatic fibrosis burden during monitoring in the referral center.
Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
Authors: Okada Kana , Nishizawa Kayo , Kobayashi Tomoko , Sakata Shogo , Hashimoto Kouichi , Kobayashi Kazuto 
Published: June 2021

AbstractSocial behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer’s disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social ability. The cholinergic system is a potential constituent for the neural mechanisms underlying social behaviour, and impaired social ability in AD may have a cholinergic basis. However, the involvement of cholinergic function in social behaviour has not yet been fully understood. Here, we performed a selective elimination of cholinergic cell groups in the basal forebrain in mice to examine the role of cholinergic function in social interaction and social recognition memory by using the three-chamber test. Elimination of cholinergic neurons in the medial septum (MS) and vertical diagonal band of Broca (vDB) caused impairment in social interaction, whereas ablating cholinergic neurons in the nucleus basalis magnocellularis (NBM) impaired social recognition memory. These impairments were restored by treatment with cholinesterase inhibitors, leading to cholinergic system activation. Our findings indicate distinct roles of MS/vDB and NBM cholinergic neurons in social interaction and social recognition memory, suggesting that cholinergic dysfunction may explain social ability deficits associated with AD symptoms.
Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
Authors: Mika Justyna , Tobiasz Joanna , Zyla Joanna , Papiez Anna , Bach Małgorzata , Werner Aleksandra , Kozielski Michał , Kania Mateusz , Gruca Aleksandra , Piotrowski Damian , Sobala-Szczygieł Barbara , Włostowska Bożena , Foszner Paweł , Sikora Marek , Polanska Joanna , Jaroszewicz Jerzy 
Published: June 2021

AbstractIn the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative symptoms in SARS-CoV-2( +) patients at early infection stage were loss of taste/smell (OR = 3.33,p < 0.0001), body temperature above 38℃ (OR = 1.67,p < 0.0001), muscle aches (OR = 1.30,p = 0.0242), headache (OR = 1.27,p = 0.0405), cough (OR = 1.26,p = 0.0477). Dyspnea was more often reported among SARS-CoV-2(-) (OR = 0.55,p < 0.0001). Cough and dyspnea were 3.5 times more frequent among SARS-CoV-2(-) (OR = 0.28,p < 0.0001). Co-occurrence of cough, muscle aches, headache, loss of taste/smell (OR = 4.72,p = 0.0015) appeared significant, although co-occurrence of two symptoms only, cough and loss of smell or taste, means OR = 2.49 (p < 0.0001). Temperature > 38℃ with cough was most frequent in men (20%), while loss of taste/smell with cough in women (17%). For younger people, taste/smell impairment is sufficient to characterise infection, whereas in older patients co-occurrence of fever and cough is necessary. The presented study objectifies the single symptoms and interactions significance in COVID-19 diagnoses and demonstrates diverse symptomatology in patient groups.
Behavior and body size modulate the defense of toxin-containing sawfly larvae against ants
Authors: Boevé Jean-Luc 
Published: June 2021

AbstractThe sawfly larvae of most Argidae and Pergidae (Hymenoptera: Symphyta) species contain toxic peptides, and these along with other traits contribute to their defense. However, the effectiveness of their defense strategy, especially against ants, remains poorly quantified. Here, five Arge species, A. berberidis, A. nigripes, A. ochropus, A. pagana, A. pullata, plus three Pergidae species, Lophyrotoma analis, Lophyrotoma zonalis, Philomastix macleaii, were tested in laboratory bioassays on ant workers mainly of Myrmica rubra. The experiments focused on short-term predator–prey interactions, sawfly survival rate after long-term interactions, and feeding deterrence of the sawfly hemolymph. The larvae of Arge species were generally surrounded by few ants, which rarely bit them, whereas larvae of Pergidae, especially P. macleaii, had more ants around with more biting. A detailed behavioral analysis of Arge-ant interactions revealed that larval body size and abdomen raising behavior were two determinants of ant responses. Another determinant may be the emission of a volatile secretion by non-eversible ventro-abdominal glands. The crude hemolymph of all tested species, the five Arge species and L. zonalis, was a strong feeding deterrent and remained active at a ten-fold dilution. Furthermore, the study revealed that the taxon-specific behavior of ants, sting or spray, impacted the survival of A. pagana but not the large body-sized A. pullata. The overall results suggest that the ability of Arge and Pergidae larvae to defend against ants is influenced by the body size and behavior of the larvae, as well as by chemicals.
Identification of subtypes of anticancer peptides based on sequential features and physicochemical properties
Authors: Huang Kai-Yao , Tseng Yi-Jhan , Kao Hui-Ju , Chen Chia-Hung , Yang Hsiao-Hsiang , Weng Shun-Long 
Published: June 2021

AbstractAnticancer peptides (ACPs) are a kind of bioactive peptides which could be used as a novel type of anticancer drug that has several advantages over chemistry-based drug, including high specificity, strong tumor penetration capacity, and low toxicity to normal cells. As the number of experimentally verified bioactive peptides has increased significantly, various of in silico approaches are imperative for investigating the characteristics of ACPs. However, the lack of methods for investigating the differences in physicochemical properties of ACPs. In this study, we compared the N- and C-terminal amino acid composition for each peptide, there are three major subtypes of ACPs that are defined based on the distribution of positively charged residues. For the first time, we were motivated to develop a two-step machine learning model for identification of the subtypes of ACPs, which classify the input data into the corresponding group before applying the classifier. Further, to improve the predictive power, the hybrid feature sets were considered for prediction. Evaluation by five-fold cross-validation showed that the two-step model trained with sequence-based features and physicochemical properties was most effective in discriminating between ACPs and non-ACPs. The two-step model trained with the hybrid features performed well, with a sensitivity of 86.75%, a specificity of 85.75%, an accuracy of 86.08%, and a Matthews Correlation Coefficient value of 0.703. Furthermore, the model also consistently provides the effective performance in independent testing set, with sensitivity of 77.6%, specificity of 94.74%, accuracy of 88.99% and the MCC value reached 0.75. Finally, the two-step model has been implemented as a web-based tool, namely iDACP, which is now freely available athttp://mer.hc.mmh.org.tw/iDACP/.
Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations
Authors: Salam Shaakir , Tacconelli Sara , Smith Bradley N. , Mitchell Jacqueline C. , Glennon Elizabeth , Nikolaou Nikolas , Houart Corinne , Vance Caroline 
Published: June 2021

AbstractAberrantly expressed fused in sarcoma (FUS) is a hallmark of FUS-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Wildtype FUS localises to synapses and interacts with mitochondrial proteins while mutations have been shown to cause to pathological changes affecting mitochondria, synapses and the neuromuscular junction (NMJ). This indicates a crucial physiological role for FUS in regulating synaptic and mitochondrial function that is currently poorly understood. In this paper we provide evidence that mislocalised cytoplasmic FUS causes mitochondrial and synaptic changes and that FUS plays a vital role in maintaining neuronal health in vitro and in vivo. Overexpressing mutant FUS altered synaptic numbers and neuronal complexity in both primary neurons and zebrafish models. The degree to which FUS was mislocalised led to differences in the synaptic changes which was mirrored by changes in mitochondrial numbers and transport. Furthermore, we showed that FUS co-localises with the mitochondrial tethering protein Syntaphilin (SNPH), and that mutations in FUS affect this relationship. Finally, we demonstrated mutant FUS led to changes in global protein translation. This localisation between FUS and SNPH could explain the synaptic and mitochondrial defects observed leading to global protein translation defects. Importantly, our results support the ‘gain-of-function’ hypothesis for disease pathogenesis in FUS-related ALS.
High-strength cellulose nanofiber/graphene oxide hybrid filament made by continuous processing and its humidity monitoring
Authors: Kim Hyun Chan , Panicker Pooja S. , Kim Debora , Adil Samia , Kim Jaehwan 
Published: June 2021

AbstractHuman-made natural-fiber-based filaments are attractive for natural fiber-reinforced polymer (NFRP) composites. However, the composites' moisture distribution is critical, and humidity monitoring in the NFRP composites is essential to secure stability and keep their life span. In this research, high strength and humidity sensing filament was developed by blending cellulose nanofiber (CNF) and graphene oxide (GO), wet-spinning, coagulating, and drying, which can overcome the heterogeneous mechanical properties between embedded-type humidity sensors and NFRP composites. The stabilized synthesis process of the CNF-GO hybrid filament demonstrated the maximum Young's modulus of 23.9 GPa and the maximum tensile strength of 439.4 MPa. Furthermore, the achieved properties were successfully transferred to a continuous fabrication process with an additional stretching process. Furthermore, its humidity sensing behavior is shown by resistivity changes in various temperature and humidity levels. Therefore, this hybrid filament has excellent potential for in-situ humidity monitoring by embedding in smart wearable devices, natural fiber-reinforced polymer composites, and environmental sensing devices.
Intelligent protection coordination restoration strategy for active distribution networks
Authors: Hojjaty Mahmoud , Fani Bahador , Sadeghkhani Iman 
Published: June 2021

AbstractDespite various advantages of integrating distributed generation (DG) units into distribution networks such as power loss reduction and voltage profile improvement, they may disrupt the performance of the conventional protection system due to bidirectional power flow and change of short‐circuit power. With the development of multi‐agent systems (MASs), intelligent protection schemes have been introduced that operate on the basis of data processing by a central controller. However, the possibility of communication failure and cyber attacks reduce reliability of these protection systems. To address this problem, this paper proposes an intelligent protection scheme that relies on peer‐to‐peer communication between agents in the first layer of the MAS. In the case of communication failure, the agents react to the fault condition by using the available data for similar conditions. The main advantages of the proposed scheme are reduction of number of employed agents by using only relay agents and no need for communicating with higher layers of MAS. Implementation of the proposed scheme in the ETAP simulation model of a 14 bus active distribution network shows that data exchange between relay agents properly modifies the operating time of the relays, resulting in protection coordination between main and backup protections.
Internal calibration of Gaia BP/RP low-resolution spectra
Authors: Carrasco J. M. , Weiler M. , Jordi C. , Fabricius C. , De Angeli F. , Evans D. W. , van Leeuwen F. , Riello M. , Montegriffo P. 
Published: June 2021

Context. The full third Gaia data release will provide, for the first time, the calibrated spectra obtained with the blue and red Gaia slitless spectrophotometers (BP and RP, respectively). Gaia is a very complex mission and cannot be considered as a single instrument, but rather as many instruments. The two lines of sight with wide fields of view introduce strong variations of the observations across the large focal plane with more than one hundred different detectors. The main challenge when facing Gaia spectral calibration is that no lamp spectra or flat fields are available during the mission. Also, the significant size of the line spread function with respect to the dispersion of the prisms produces alien photons contaminating neighbouring positions of the spectra. This makes the calibration special and different from standard approaches.
Aims. This work gives a detailed description of the internal calibration model for the spectrophotometric data used to obtain the content of the Gaia catalogue. The main purpose of the internal calibration is to bring all the epoch spectra onto a common flux and pixel (pseudo-wavelength) scale, taking into account variations over the focal plane and with time, producing a mean spectrum from all the observations of the same source.
Methods. In order to describe all observations on a common mean flux and pseudo-wavelength scale, we constructed a suitable representation of the internally calibrated mean spectra via basis functions, and we described the transformation between non-calibrated epoch spectra and calibrated mean spectra via a discrete convolution, parametrising the convolution kernel to recover the relevant coefficients.
Results. The model proposed here for the internal calibration of the Gaia spectrophotometric observations is able to combine all observations into a mean instrument to allow the comparison of different sources and observations obtained with different instrumental conditions along the mission and the generation of mean spectra from a number of observations of the same source. We derived a calibration model that can handle the self-calibrating nature of the problem. The output of this model provides the internal mean spectra, not as a sampled function (flux and wavelength), but as a linear combination of basis functions, although sampled spectra can easily be derived from them.
Synthesis of Longhorn Beetle Pheromone Components by Proline-Mediated α-Hydroxylation of Alkyl Ketones
Authors: Heguaburu Viviana Lucía , do Carmo Hugo , Amorós María Eugenia , González Andrés 
Published: June 2021

AbstractThe stereoselective synthesis of several components of the aggregation pheromones of numerous longhorn beetle species is described. These attractants consist of 3-hydroxy-2-alkanones and 2,3-alkyldiols­ with chain lengths varying from six to ten carbons. The 3R- and 3S-series are generated by organocatalytic α-hydroxylation of alkyl ketones with nitrosobenzene in the presence of l- or d-proline, respectively, to obtain the hydroxyketones in high enantiomeric excess. Further reduction and chromatographic separation lead to the enantiomerically pure diols that complete the library.
U.S. News & World Report Ophthalmology Hospital Rankings and Research Productivity
Authors: Lin John C. , Chen Allison J. , Scott Ingrid U. , Greenberg Paul B. 
Published: June 2021

Abstract
Introduction Despite the wide usage of U.S. News & World Report (U.S. News) rankings of ophthalmology hospitals among the public, residency applicants, and ophthalmologists, there is disagreement in the literature on the role of quality of care, research productivity, and other factors in the ranking system. This study investigated the association of U.S. News ranking of ophthalmology hospitals and objective measures of research productivity.
Methods The 2020 U.S. News “Best Hospitals for Ophthalmology” ranking lists 38 hospitals by reputation score and numerically ranks the top 12 institutions. For our analysis, top 12 hospitals were classified as group A and the remaining 26 as group B. The Clinicaltrials.gov, National Institutes of Health (NIH) Research Portfolio Online Reporting Tools Expenditures and Results (RePORTER), and NIH Research Portfolio Online Reporting Tools (RePORT) were systematically searched for total clinical trials, NIH funding, and the National Eye Institute (NEI) funding for fiscal years 2017, 2018, and 2019. Faculty size and the number of publications by ophthalmology faculty per hospital were recorded from a previous study in 2016.
Results Independent measures of research productivity significantly associated with group A status after multivariate logistic regression analysis were mean faculty Hirsch's index (h-index) over 15 (odds ratio [OR]: 6.13, 95% confidence interval [CI]: [1.14–32.94]) and conducting five or more total clinical trials (OR: 8.77, 95% CI: [1.39–55.16]).
Conclusion This study suggests that the reputation-based U.S. News ranking may serve as a proxy for an ophthalmology department's contribution to research measured by mean faculty h-index and number of clinical trials.
Dermal Fillers for Tear Trough Rejuvenation: A Systematic Review
Authors: Trinh Lily N. , Grond Sarah E. , Gupta Amar 
Published: June 2021

AbstractThere is significant variation in treatment parameters when treating the infraorbital region. Thorough knowledge of these pertinent factors, choice of the optimal filling material, and proper understanding of the anatomy of this unforgiving region will contribute to a safe, effective, and natural result. We aim to conduct a systematic review of published literature related to soft tissue fillers of the tear trough and infraorbital region. A search of published literature was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and included PubMed, Embase, and Science Direct databases. The Medical Subject Headings (MeSH) terms used were “tear trough” OR “infraorbital” AND “dermal filler” OR “hyaluronic acid” OR “poly-L-lactic acid” OR “calcium hydroxyapatite” OR “Restylane” OR “Radiesse” OR “Perlane” OR “Juvéderm” OR “Belotero.” Different combinations of these key terms were used. The initial search identified 526 articles. Six additional articles were identified through references. Two-hundred twenty-five duplicates were removed. A total of 307 studies were screened by title and abstract and 258 studies were eliminated based on inclusion and exclusion criteria. Forty-nine articles underwent full-text review. The final analysis included 23 articles. Patient satisfaction was high, and duration of effect ranged from 8 to 12 months. Restylane was most commonly used. Injection technique varied, but generally involved placing filler pre-periosteally, deep to orbicularis oculi muscle, anterior to the inferior orbital rim via serial puncture or retrograde linear threading with a 30-gauge needle. Topical anesthetic was most commonly used. Side effects were generally mild and included bruising, edema, blue–gray dyschromia, and contour irregularities. Nonsurgical correction of the tear trough deformity with soft tissue filler is a minimally invasive procedure with excellent patient satisfaction with long-lasting effects. It is essential to have a fundamental understanding of the relevant anatomy and ideal injection technique to provide excellent patient outcomes and prevent serious complications.
Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales
Authors: Ludwig Hans C. , Bock Hans C. , Gärtner Jutta , Schiller Stina , Frahm Jens , Dreha-Kulaczewski Steffi 
Published: June 2021

AbstractNew experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids: (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow–Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease.
Interaction of counterpropagating waves in a Nd :YVO4 ring laser
Authors: Lariontsev E.G. , Firsov V.V. , Chekina S.N. 
Published: June 2021

Abstract
We have experimentally studied the stationary regime of bidirectional lasing and self-modulation regimes in a Nd :YVO4 solid-state ring laser (SSRL) in the presence of phase nonreciprocity of the ring cavity. It is found that the emission spectrum in the regime of frequency matching of counterpropagating waves is much narrower than in a Nd :YAG SSRL. When the phase nonreciprocity increases in the matching regime, one of the counterpropagating waves is suppressed, and this regime does not switch to the beat regime.
Effect of elastic anisotropy on thermally induced distortions of a laser beam in single cubic syngony crystals with radial cooling. Part II
Authors: Vyatkin A.G. 
Published: June 2021

Abstract
We report a study of thermally induced depolarisation of a laser beam in single cubic syngony crystals of 432,

, and m3m symmetry groups with an anisotropic elastic stiffness tensor. For active elements in the form of a long rod and a thin disk with radial cooling under uniform volume pumping, we investigate the effect of anisotropy of elastic properties on the dependence of the degree of depolarisation in the crystal on the orientation of the crystallographic axes, as well as on the position of the critical orientation in the crystallographic coordinate system.