bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food Wastage, a Threat to Indonesian Tourism
Authors: Lemy Diena Mutiara , Kusumo Elang , Brian Reagan 
Published: December 2024

The tourism sector have the impact to environmental as it shifts towards sustainable tourism development. Food waste is a one of environment continuing global issue possessing sustainability challenges in the tourism sector. Food waste is edible food that is discarded, negatively impacting environmental health. As per the 2020 report from the Food and Agriculture Organization (FAO), approximately one-third of all food produced for human consumption globally is wasted or discarded. Indonesia is among the leading producers of food waste in Southeast Asia. The 2021 UNEP annual report, food waste in Indonesia totals 20.93 million tons. The Tourism food and beverage sector, some of the biggest contributors to food waste, along with, is also by the behavior of people who may not be aware of the negative effects on food waste. This study using Qualitative method approach, with the data such as media journals, reports, journals articles and books, and will explore the behavior of domestic tourists towards food waste, especially in the Labuan Bajo area, which is one of the super priority tourist destinations in Indonesia. The study's findings give an overview of how people's attitudes and knowledge are influenced food wastage behavior.
Tantangan Sektor Pertanian dalam Memenuhi Kebutuhan Pangan Berkelanjutan
Authors: Ibnu Muhammad 
Published: December 2024

ENGLISHThe challenges faced by agricultural sector are so complex. This study aims to analyze the main challenges (priorities) for agricultural sector, both nationally and globally. This study used a qualitative method which is a literature review of 100 studies published in the last 10 years (2013-2023). The results of the study show that the main challenges for agricultural sector stem from 8 (eight) aspects, namely climate change and risks of water deficits, energy, biodiversity and ecosystem services, social infrastructure, governance and policies, food supply chains, consumption patterns, and intensification of sustainable agriculture. This study concludes that sustainable agriculture and food systems require strong and balanced knowledge of agronomy and ecology, strengthening of social capital based on farmer/community participation, and policies that focus on the goals of environmental preservation and human welfare and are free from political interests of few parties. INDONESIATantangan yang dihadapi oleh sektor pertanian sangat kompleks. Penelitian ini bertujuan untuk menganalisis tantangan-tantangan bagi sektor pertanian, baik nasional maupun global. Penelitian ini bersifat kualitatif dan metode yang digunakan adalah ulasan/kajian literatur terhadap 143 studi yang dipublikasikan dalam periode 2014-2024 atau 10 tahun terakhir. Hasil penelitian menunjukkan bahwa tantangan utama bagi sektor pertanian bersumber dari 8 (delapan) aspek, yaitu perubahan iklim dan risiko defisit air, energi, keanekaragaman hayati dan jasa ekosistem, infrastruktur sosial, tata kelola dan kebijakan, rantai pasokan pangan, pola konsumsi, dan intensifikasi pertanian berkelanjutan. Penelitian ini menyimpulkan bahwa sistem pertanian dan pangan berkelanjutan memerlukan pengetahuan tentang agronomi dan ekologi yang luas dan seimbang, penguatan modal sosial yang berbasis partisipasi petani/masyarakat, dan kebijakan yang fokus pada tujuan pelestarian lingkungan dan kesejahteraan umat manusia serta bebas dari kepentingan politik pihak-pihak tertentu.
A novel multi-level 3D pose estimation framework for gait detection of Parkinson’s disease using monocular video
Authors: He Rong , You Zijing , Zhou Yongqiang , Chen Guilan , Diao Yanan , Jiang Xiantai , Ning Yunkun , Zhao Guoru , Liu Ying 
Published: December 2024

IntroductionParkinson's disease (PD) is characterized by muscle stiffness, bradykinesia, and balance disorders, significantly impairing the quality of life for affected patients. While motion pose estimation and gait analysis can aid in early diagnosis and timely intervention, clinical practice currently lacks objective and accurate tools for gait analysis.MethodsThis study proposes a multi-level 3D pose estimation framework for PD patients, integrating monocular video with Transformer and Graph Convolutional Network (GCN) techniques. Gait temporal and spatial parameters were extracted and verified for 59 healthy elderly and PD patients, and an early prediction model for PD patients was established.ResultsThe repeatability of the gait parameters showed strong consistency, with most of the estimated parameters yielding an Intraclass Correlation Coefficient (ICC) greater than 0.70. Furthermore, these parameters exhibited a high correlation with VICON and ATMI results (r &gt; 0.80). The classification model based on the extracted parameter features, using a Random Forest (RF) classifier, achieved an accuracy of 93.3%.ConclusionThe proposed 3D pose estimation method demonstrates high reliability and effectiveness in providing accurate 3D human pose parameters, with strong potential for early prediction of PD.SignificanceThis markerless method offers significant advantages in terms of low cost, portability, and ease of use, positioning it as a promising tool for monitoring and screening PD patients in clinical settings.
Extension of an ICU-based noninvasive model to predict latent shock in the emergency department: an exploratory study
Authors: Wu Mingzheng , Li Shaoping , Yu Haibo , Jiang Cheng , Dai Shuai , Jiang Shan , Zhao Yan 
Published: December 2024

BackgroundArtificial intelligence (AI) has been widely adopted for the prediction of latent shock occurrence in critically ill patients in intensive care units (ICUs). However, the usefulness of an ICU-based model to predict latent shock risk in an emergency department (ED) setting remains unclear. This study aimed to develop an AI model to predict latent shock risk in patients admitted to EDs.MethodsMultiple regression analysis was used to compare the difference between Medical Information Mart for Intensive Care (MIMIC)-IV-ICU and MIMIC-IV-ED datasets. An adult noninvasive model was constructed based on the MIMIC-IV-ICU v3.0 database and was externally validated in populations admitted to an ED. Its efficiency was compared with efficiency of testing with noninvasive systolic blood pressure (nSBP) and shock index.ResultsA total of 50,636 patients from the MIMIC-IV-ICU database was used to develop the model, and a total of 2,142 patients from the Philips IntelliSpace Critical Care and Anesthesia (ICCA)-ED and 425,087 patients from the MIMIC-IV-ED were used for external validation. The modeling and validation data revealed similar non-invasive feature distributions. Multiple regression analysis of the MIMIC-IV-ICU and MIMIC-IV-ED datasets showed mostly similar characteristics. The area under the receiver operating characteristic curve (AUROC) of the noninvasive model 10 min before the intervention was 0.90 (95% CI: 0.84–0.96), and the diagnosis accordance rate (DAR) was above 80%. More than 80% of latent shock patients were identified more than 70 min earlier using the noninvasive model; thus, it performed better than evaluating shock index and nSBP.ConclusionThe adult noninvasive model can effectively predict latent shock occurrence in EDs, which is better than using shock index and nSBP.
Modelling the economic and environmental impacts of water resources in the context of climate neutrality in the EUSDR member states
Authors: Ionescu Romeo Victor , Zlati Monica Laura , Antohi Valentin Marian , Cristea Dragoș Sebastian , Petrea Ștefan Mihai , Forțea Costinela 
Published: December 2024

IntroductionThis study explores the economic and environmental impacts of water resources in the context of achieving climate neutrality in the EU Strategy for the Danube Region (EUSDR). The research is focused on eight EUSDR member states: Bulgaria, Czechia, Germany, Croatia, Hungary, Austria, Romania, and Slovakia, with the aim of analyzing the dynamic relationship between water resources, economic growth, and environmental sustainability. Given the ambitious goals of the European Green Deal, this study examines how water management can support the transition towards climate neutrality.MethodsA dynamic econometric model was developed using a consolidated database of relevant climate neutrality indicators from 2010 to 2021. The selected indicators included GDP per capita, water use in agriculture, gross water abstraction, sewage sludge production, and water productivity. The econometric model was validated using statistical tools such as the One-Sample Kolmogorov-Smirnov Test, and analysis was conducted using Gretl and IBM-SPSS 25 software.ResultsThe findings reveal that water resources management significantly contributes to the achievement of climate neutrality targets. The model achieved over 86% significance in explaining the financial efforts needed to achieve the Green Deal’s 2030 and 2050 goals. Moreover, water productivity and investments in water-related infrastructure were found to play critical roles in ensuring the success of these climate policies.DiscussionThe results highlight the importance of policy coordination across the EUSDR member states and the need for increased investment in sustainable water resource management. Achieving climate neutrality requires addressing economic disparities between states and enhancing regional cooperation.ConclusionThe proposed dynamic model offers a valuable tool for monitoring progress towards climate neutrality, particularly in relation to water resource management. This research underlines the need for targeted policy interventions and investments to meet the Green Deal’s goals while safeguarding the region's water resources.
Factors affecting population density and colonization success of two non-native beetle species with different breeding/life-history strategies
Authors: Cocoș Dragoș , Klapwijk Maartje J. , Björkman Christer , Ravn Hans Peter , Schroeder Martin 
Published: December 2024

IntroductionBark and longhorn beetles have become of increasing concern as invasive pests as they are transported across the globe. The larch bark beetle Ips cembrae and the larch longhorn beetle Tetropium gabrieli are two species that have recently established in Scandinavia. We asked the following questions for both I. cembrae and T. gabrieli: (i) How does habitat availability affect the relative population density? (ii) How is the colonization probability related to the relative population density? (iii) What is the relationship between relative population densities of the beetles and enemy pressure?MethodsThe relative population density of the two beetle species were assessed with two pheromone-baited traps for each beetle species in 36 pure larch stands distributed in southern Sweden and Denmark. In addition, colonization success was recorded on five cut larch trees in 30 of the 36 larch stands.ResultsIps cembrae was trapped in 19 stands and had colonized cut trees in two stands, whereas Tetropium gabrieli was trapped in 18 stands and had colonized cut trees in 12 stands. Both species showed a positive relationship between the relative population density and the probability of colonization of the cut trees. For I. cembrae a higher population size was required for colonization than for T. gabrieli. The relative population density of both species was positively related to the amount of habitat.DiscussionThe difference in the population size required for colonization between the two studied species might be explained by their different reproductive strategies. The results are discussed in terms of host location and mate finding, and predation pressure.
Case report: Toxic epidermal necrolysis induced by tislelizumab in a patient with esophageal squamous cell carcinoma
Authors: Wu Shilong , Xu Chenyang , Liu Huafeng 
Published: December 2024

BackgroundImmune checkpoint inhibitors (ICIs) have been widely applicated for the treatment of patients with advanced esophageal cancer. Skin-related adverse reactions are frequent with ICIs, with toxic epidermal necrolysis (TEN) being a severe and potentially life-threatening cutaneous reaction.Case presentationWe present a case of a 70-year-old male with locally advanced esophageal cancer who developed severe toxic epidermal necrolysis (TEN) after 18 days of tislelizumab combined with chemotherapy. The condition rapidly progressed to cover approximately 90% of his body. After treatment with intravenous methylprednisolone, immunoglobulin, and antibiotics, along with active nutritional support and wound care, the patient recovered from TEN induced by tislelizumab.ConclusionTreatment for TEN is complex, and no standardized guidelines currently exist. We propose an economical, safe, effective, and simple strategy for similar TEN patients.
Optic nerve-mediated modulation of temporally interfering electric fields for potential targeted retinal disease therapy: a computational modeling study
Authors: Zhou Meixuan , Su Xiaofan , Guo Tianruo , Meng Tianyue , Wu Weilei , Di Liqing , Li Liming , Li Heng , Chai Xinyu 
Published: December 2024

IntroductionTraditional extraocular electrical stimulation typically produces diffuse electric fields across the retina, limiting the precision of targeted therapy. Temporally interfering (TI) electrical stimulation, an emerging approach, can generate convergent electric fields, providing advantages for targeted treatment of various eye conditions.ObjectiveUnderstanding how detailed structures of the retina, especially the optic nerve, affects electric fields can enhance the application of TI approach in retinal neurodegenerative and vascular diseases, an essential aspect that has been frequently neglected in previous researches.MethodsWe developed an anatomically accurate multi-layer human eye model, incorporating the optic nerve segment and setting it apart from current research endeavors. Based on this model, we conducted in silico investigations to predict the influence of the optic nerve on spatial characteristics of the temporally interfering electric field (TIEF) generated by diverse electrode configurations.ResultsOptic nerve directly influenced spatial distributions and modulation rules of TIEFs. It caused convergent areas to shift nasally or temporally in relation to return electrode positions, and further increased the axial anisotropy within the convergent TIEF. Furthermore, alterations in electrode positions and adjustments to current ratios among channels induced diverse spatial patterns of TIEFs within the macular region, the area surrounding the optic nerve, as well as peripheral retina.ConclusionOur findings suggested that presence of the optic nerve necessitated the utilization of different modulating paradigms when employing TI strategy for targeted treatment of various retinal lesions. And also provided theoretical references for developing a novel retinal electrical stimulation therapeutic device based on TI technology.
Transient hypothyroidism in a neonate following maternal exposure to vinblastine during pregnancy: a case report and review
Authors: Amin Zubair , Aung Win Thu , Ng Yvonne Peng Mei 
Published: December 2024

BackgroundVinblastine is a widely used chemotherapeutic agent for various cancers. We report a case of transient congenital hypothyroidism following maternal exposure to vinblastine during the third trimester of pregnancy and propose possible mechanisms of action.MethodWe utilized the CARE guidelines to report the case.Case presentationThe mother is a 30-year-old previously healthy Malay woman who was diagnosed with Hodgkin lymphoma during her 28th week of pregnancy. She received two cycles of vinblastine monotherapy during her third trimester. She delivered a healthy baby girl at 37 weeks of gestation. Cord blood screening for congenital hypothyroidism and subsequent thyroid function tests showed evidence of congenital hypothyroidism. An ultrasound scan of the baby confirmed the presence of the thyroid gland, but there was no uptake of radionuclide tracer by the thyroid gland, thereby ruling out thyroid dysgenesis or dyshormonogenesis as the plausible cause of hypothyroidism. The baby was treated with replacement thyroxine for 18 months with eventual normal growth and development.ConclusionThis is the first reported case of transient congenital hypothyroidism following maternal exposure to vinblastine during the third trimester of pregnancy. Although direct causation cannot be established, heightened awareness of neonatal hypothyroidism is recommended after exposure to vinblastine or similar drugs in pregnancy.
Diagnostic challenges of long COVID in children: a survey of pediatric health care providers’ preferences and practices
Authors: Liu Vivian Y. , Godfrey Madeleine , Dunn Matthew , Fowler Robert , Guthrie Lauren , Dredge David , Holmes Scott , Johnston Alicia M. , Simoneau Tregony , Fasano Alessio , Ericson Dawn , Yonker Lael M. 
Published: December 2024

IntroductionGiven the challenges in diagnosing children with long COVID, we sought to explore diagnostic practices and preferences among clinicians.MethodsA ten-question survey assessed pediatric providers’ clinical decision making for identifying and evaluating long COVID in children. Of the 120 survey respondents, 84 (70%) were physicians, 31 (26%) nurse practitioners, and 5 (4%) physician assistants.ResultsThe most common categories of symptoms identified as raising suspicion for long COVID in children included cardiopulmonary symptoms, selected by 119 (99%) of pediatric providers, and neurocognitive symptoms, selected by 118 (98%) of providers. However, there was more ambiguity on the primary feature of long COVID, with providers selecting a range of key symptoms. Of all physical exam findings, postural orthostatic tachycardia, was most suggestive of long COVID [identified by 49 (41%) of pediatric providers], whereas one-third of providers reported no specific identifiable exam finding.DiscussionPediatric providers report variable decision making in the clinical evaluation of long COVID, with patient demographics and clinical factors impacting whether a diagnosis of long COVID is considered. This variation in diagnosing pediatric long COVID reflects ambiguity in the definition of long COVID in children and the absence of clinical guidelines to support providers in the identification of disease and treatment. This study highlights an area of need for future clinical advances in pediatric long COVID.
Comparison of trans-umbilical single-port laparoscopic complete extraperitoneal closure and laparoscopic intracorporeal closure for pediatric inguinal hernia: a randomized controlled study
Authors: Li Yanyi , Jin Zhu , Tang Chengyan , Gong Yuan , Huang Lu , Du Qing , Xia Xinrong , Zhu Daiwei , Zhou Wankang , Li Zeping , Wang Weiao , Liu Yuanmei , Zheng Zebing 
Published: December 2024

BackgroundThe purpose of this study was to compare the outcomes of Trans-umbilical single-port laparoscopic complete extraperitoneal closure (LCEC) and laparoscopic intracorporeal closure (LIC) for inguinal hernia by analysis of follow-up data over 5 years.MethodsIn this prospective randomized controlled trial, 524 children with inguinal hernia were randomly assigned to undergo LCEC or LIC between August 2016 and December 2017. The primary outcome measures were the success and recurrence rates. The secondary outcome measures were operative time; length of hospital stay; postoperative pain score; and incidence of postoperative complications, including rates of wound infection, stitch abscess, and testicular atrophy.ResultsPrimary analysis of the 227 patients in the LIC group and 215 patients in the LCEC group revealed that in the LCEC group, the success rate of was significantly higher in LCEC group (96.7% vs. 90.3%, P &lt; .05) and the length of hospital stay was significantly shorter (P &lt; .05) than those of the LIC group. Neither the recurrence rate (P &gt; .05) nor the operative time (P &gt; .05) of the groups significantly differed. The pain scores at postoperative 12 and 24 h were significantly lower in the LCEC group than in the LIC group (P &lt; .05). The incidence rates of wound infection (0.93% vs. 5.7%, P &lt; .05) and stitch abscess (1.4% vs. 7.0%, P &lt; .05) were significantly lower in the LCEC group than in the LIC group. No testicular atrophy occurred in either group.ConclusionLCEC is associated with better clinical success and fewer postoperative complications for repair of pediatric inguinal hernia compared with LIC.
Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments
Authors: Zhao Xuanlin , Li Fan , Wen Ao , Yu Xiuxian , Xu Xinrui , Wan Chengyu , Cao Yu , Xin Guang , Huang Wen 
Published: December 2024

IntroductionAcute pancreatitis (AP) is a severe inflammatory disease of the pancreas that could trigger a systemic inflammation and multi-organ dysfunction. Stigmasterol, a natural plant sterol found in various herbs and vegetables, exhibits a significant anti-inflammatory, antioxidant, and cholesterol-lowering effects. However, its therapeutic potential in AP have not been thoroughly investigated.MethodsThe present study employed network pharmacology combined with experimental verification to explore the protective effect of stigmasterol on AP and its molecular mechanism in a sodium taurocholate (STC)-induced AP mouse model.ResultsProtein-protein interaction (PPI) analysis pinpointed out MAPK3, also named as ERK1, as a promising stigmasterol target in AP therapy. Molecular docking analysis further revealed a strong binding capacity of stigmasterol to ERK1 (−6.57 kL/mol). Furthermore, both in vivo and in vitro studies demonstrated that stigmasterol treatment notably attenuated STC-induced pancreatic injury, as evidented by decreased serum levels of lipase and amylase, improved systemic inflammation, and reduced acinar cell necrosis. At the molecular level, stigmasterol treatment exhibited a significant inhibition on STC-induced activation of ERK signaling pathway in pancreatic acinar cells, leading to the transition of acinar cell death from necrosis to apoptosis, thereby preventing acinar cell necrosis-induced systemic inflammation.ConclusionThis study demonstrated that stigmasterol exhibits a significant protective effect aganist AP, at least in part through enhancing acinar cell apoptosis via modulating the ERK signaling pathways.
Lyrics do matter: how “coping songs” relate to well-being goals. The COVID pandemic case
Authors: Levy Adi , Granot Roni , Peres Renana 
Published: December 2024

IntroductionIn stressful times, people often listen to “coping songs” that help them reach emotional well-being goals. This paper is a first attempt to map the connection between an individual’s well-being goals and their chosen coping song.MethodsWe assembled a large-scale dataset of 2,804 coping songs chosen by individuals from 11 countries during COVID-19 lockdown. Individuals reported their well-being goals and also named their coping song. We applied an unsupervised topic-modeling approach to identify 15 self-emerging topics from the song lyrics, and connected them to well-being goals.ResultsWe found significant association between certain lyrics’ topics and specific well-being goals. This association weakened for participants for which music is highly important. No significant patterns were found for the songs’ acoustic features.DiscussionThis paper posits that song lyrics, despite their brevity and presumed simplicity, can be meaningful for self-regulation of emotional states, and should receive more attention by researchers and streaming services alike.