bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebellar Theta Burst Stimulation on Walking Function in Stroke Patients: A Randomized Clinical Trial
Authors: Xie Yun-Juan , Wei Qing-Chuan , Chen Yi , Liao Ling-Yi , Li Bao-Jin , Tan Hui-Xin , Jiang Han-Hong , Guo Qi-Fan , Gao Qiang 
Published: October 2021

Objectives: The objective of this study was to explore the efficacy of cerebellar intermittent theta burst stimulation (iTBS) on the walking function of stroke patients.Methods: Stroke patients with walking dysfunction aged 25–80 years who had suffered their first unilateral stroke were included. A total of 36 patients [mean (SD) age, 53 (7.93) years; 10 women (28%)] were enrolled in the study. All participants received the same conventional physical therapy, including transfer, balance, and ambulation training, during admission for 50 min per day during 2 weeks (10 sessions). Every session was preceded by 3 min procedure of cerebellar iTBS applyed over the contralesional cerebellum in the intervention group or by a similar sham iTBS in control group. The groups were formed randomly and the baseline characteristics showed no significant difference. The primary outcome measure was Fugl–Meyer Assessment–Lower Extremity scores. Secondary outcomes included walking performance and corticospinal excitability. Measures were performed before the intervention beginning (T0), after the first (T1) and the second (T2) weeks.Results: The Fugl–Meyer Assessment for lower extremity scores slightly improved with time in both groups with no significant difference between the groups and over the time. The walking performance significantly improved with time and between group. Two-way mixed measures ANOVA showed that there was significant interaction between time and group in comfortable walking time (F2,68 = 6.5242, P = 0.0080, η2partial = 0.276, ε = 0.641), between-group comparisons revealed significant differences at T1 (P = 0.0072) and T2 (P = 0.0133). The statistical analysis of maximum walking time showed that there was significant interaction between time and groups (F2,68 = 5.4354, P = 0.0115, η2partial = 0.198, ε = 0.734). Compared with T0, the differences of maximum walking time between the two groups at T1 (P = 0.0227) and T2 (P = 0.0127) were statistically significant. However, both the Timed up and go test and functional ambulation category scale did not yield significant differences between groups (P &gt; 0.05).Conclusion: Our results revealed that applying iTBS over the contralesional cerebellum paired with physical therapy could improve walking performance in patients after stroke, implying that cerebellar iTBS intervention may be a noninvasive strategy to promote walking function in these patients. This study was registered at ChiCTR, number ChiCTR1900026450.
Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal Development
Authors: Kowallick Mirjam , Serdar Meray , Markova Boyka , Salveridou Eva , Felderhoff-Müser Ursula , Führer-Sakel Dagmar , Heuer Heike , Bendix Ivo , Dewan Monia Vanessa 
Published: October 2021

Introduction: High oxygen concentrations have been identified as one factor contributing to the pathogenesis of the retinopathia of prematurity, chronic lung disease of the preterm infant and preterm brain injury. Preterm infants also show short- and long-term alterations of the endocrine system. If hyperoxia is one pathogenetic factor has not been investigated yet. With regard to the high prevalence of neurodevelopmental impairments in preterm infants, the hypothalamus-pituitary-thyroid (HPT) axis, the hypothalamus-pituitary-adrenal (HPA) axis and the hypothalamus-pituitary-somatotropic (HPS) axis are of special interest due to their important role in neurodevelopment.Objective: The aim of this study was to investigate the effect of hyperoxia on the endocrine system in the neonatal rat by analyzing the activities of the HPT, HPA and HPS axes, respectively.Methods: Three-days old Wistar rats were exposed to hyperoxia (oxygen 80%, 48 h). On postnatal day 5 (P5) and P11, transcript levels of thyroid-stimulating hormone (TSH), proopiomelanocortin and growth hormone (GH) were analyzed in pituitary sections by in situ hybridization. Serologic quantification of TSH and thyroxine (T4), adrenocorticotropic hormone and GH were performed by Multiplex analysis and Enzyme-linked Immunosorbent Assay.Results: At P5, significantly lower GH levels were observed in pituitaries (mRNA) and in sera of rats exposed to hyperoxia. Serum TSH was significantly elevated without changes in T4.Conclusion: This is the first study demonstrating transient endocrine alterations following hyperoxia in the neonatal rat making oxygen a possible contributor to the pathogenesis of endocrine alterations seen in preterm infants. Considering the detrimental multi-organ effects of hyperoxia on the immature organism, a rational use of therapeutic oxygen in the treatrnent of preterm infants is of utmost importance.
Focus on the Narrative Skills of Teenagers With Developmental Language Disorder and High Functioning Autism
Authors: Broc Lucie , Brassart Elise , Bragard Anne , Olive Thierry , Schelstraete Marie-Anne 
Published: October 2021

Purpose:Narratives of personal experiences emerge early in language acquisition and are particularly commonly experienced in children’s daily lives. To produce these stories, children need to develop narrative, linguistic, and social-cognitive skills. Research has shown that these skills are impaired in children with developmental language disorder (DLD) and high functioning autism (HFA).Aim:This study aimed to determine whether narrative skills are still impaired in adolescence and to highlight the language similarities and differences between teenagers with DLD and HFA in the production of a narrative of a personal experience.Method:Ten teenagers with DLD, 10 teenagers with HFA and 10 typically developing (TD) teenagers, matched on chronological age, told a narrative of a personal experience. These stories were analyzed to evaluate narrative skills through coherence (respect of the narrative schema) and cohesion (anaphora and connectors) and social-cognitive skills (affective and cognitive mental states of the characters, and arbitrary vocalizations such as voice noises).Results:Teenagers with DLD were less compliant with the complication step in the narrative schema than teenagers with HFA or TD. No difference was observed between the three groups of teenagers in terms of cohesion or regarding the positive and negative social-cognitive skills used in narratives.Conclusion:When producing a narrative of a personal experience, HFA teens do not have difficulties neither with narrative skills and with social-cognitive skills assessed in this paper. In DLD the profile of the teens is not the same: They do not have difficulties with social-cognitive skills and with a part of narrative skills (cohesion), and they have difficulties with the narrative schema.
A Comparison of Physical Activity Between Home-Based and Centre-Based Pulmonary Rehabilitation: A Randomised Controlled Secondary Analysis
Authors: Horton Elizabeth J. , Ruksenaite Justina , Mitchell Katy , Sewell Louise , Newby Christopher , Singh Sally J. 
Published: October 2021

Background: Pulmonary rehabilitation (PR) is a highly effective intervention for individuals with chronic obstructive pulmonary disease (COPD). Physical activity (PA) has been shown to increase after a centre-based programme, yet it is not clear if a home-based programme can offer the same benefit. This study aimed to evaluate the effect of home-based PR compared with the centre-based PR on the PA levels post 7 weeks of PR and 6 months follow-up.Method: In this study, 51 participants with COPD, of them, 36 (71%) men completed physical activity monitoring with a SenseWear Armband, at three time points (baseline, 7 weeks, and 6 months). The participants were randomly assigned to either centre-based supervised PR (n = 25; 69 ± 6 years; FEV1 55 ± 20% predicted) or home-based PR (n = 26; 68 ± 7 years; FEV1 42 ± 19% predicted) programmes lasting 7 weeks. The home-based programme includes one hospital visit, a self-management manual, and two telephone calls. The PA was measured as step count, time in moderate PA (3–6 metabolic equivalent of tasks [METs]) in bouts of more than 10 min and sedentary time (&lt;2 METs).Results: Home-based PR increased step count significantly more than the centre-based PR after 7 weeks (mean difference 1,463 steps: 95% CI 280–2,645, p = 0.02). There was no difference in time spent in moderate PA was observed (mean difference 62 min: 95% CI −56 to 248, p = 0.24). Sedentary behaviour was also significantly different between the centre and home-based groups. The home group spent 52 min less time sedentary compared with the centre-based (CI −106 to 2, p = 0.039). However, after 6 months, the step count and time spent in moderate PA returned to baseline in both the groups.Conclusion: This study provides an important insight into the role of home-based PR which has the potential to be offered as an alternative to the centre-based PR. Understanding who may best respond from the centre or home-based PR warrants further exploration and how to maintain these initial benefits for the long-term.Trial Registry: ISRCTN: No.: ISRCTN81189044; URL: isrctn.com.
Experimental use of stereotactic radiosurgery for non-invasive interventions in arrhythmology
Authors: Vaskovskiy V. A. , Taymasova I. A. , Kalinin D. V. , Antipina N. A. , Nikolaeva A. A. , Smirnov G. Y. , Golanov A. V. , Potapov A. A. , Revishvili A. Sh. 
Published: October 2021

Purpose. The experimental study aimed to study the effects of stereotaxic radioablation of various doses on the myocardium of the atria, ventricles and atrioventricular (AV) node in the long term (up to 6 months); as well as assessment of collateral damage during radioablation.Methods. The study comprised 4 domestic pigs. The animals were 10-12 weeks old, the average weight was 30±2.7 kg. A linear accelerator was used for the experiment. Each animal underwent radiation exposure in different areas: 1st animal - AV node (dose 35 Gy), 2nd animal - AV node and the apex of the left ventricle (LV) (dose 40/35 Gy, respectively), 3rd animal - pulmonary veins (PV) and left atrium (dose 30 Gy), 4th - AV node and LV free wall (dose 45/40 Gy). Under intravenous sedation with hemodynamic monitoring, contrast-based CT of the heart was performed to assess the degree of displacement of the heart chambers in one respiratory and cardiac cycle and to assess the anatomy of the chambers of the heart and adjacent organs. The allocation and the contouring of the target zones were carried out in three projections: axial, frontal and sagittal. For electrocardiographic control, a loop recorder was implanted in each animal. The average exposure time was 11±7 minutes. After a follow-up period, morphological examination of the autopsy material was performed.Results. The average follow-up period after ablation was 134.75±77.34 days. The electrophysiological effect of the ablation was achieved in cases of complete AV-block development. This effect was developed in 2 out of 3 animals, where AV-node was exposed: 2nd animal - 40 Gy on 108th day of observation and 4th animal - 45 Gy on 21st day of observation. No cardiac tachyarrhythmia was recorded in the animals. The results of myocardium macro- and microscopic examination showed significant changes in the target zones. These areas had precise but uneven damage boundaries, which were within the planned ones (conformal exposure with a high degree of precision). The transmural nature of the changes was noted as well. Massive fields of fibrous tissue of various degrees of maturity (with a predominance of subepicardial localization) with focal hemorrhages of various ages and granulations were detected, which were surrounded by cardiomyocytes with coagulated and vacuolated cytoplasm.Conclusion. The use of non-invasive stereotactic treatment of tachyarrhythmias has high prospects in modern electrophysiology as an alternative ablation method.
EVALUASI PENERIMAAN PENGGUNA JOGJABELAJAR.ORG DENGAN PENDEKATAN TAM DI KULON PROGO
Authors: Astuti Siwi , Soedijono Bambang , Amborowati Armadyah , Irfan Rahmatul 
Published: October 2021

ABSTRAKTechnology Acceptance Model (TAM) dan Theory of Planned Behavior (TPB) merupakan teori penerimaan teknologi yang digunakan dalam penelitian ini. Terdapat enam konstruk yang digunakan dan merupakan gabungan dari konstruk-konstruk asli yang terdapat dalam TAM dan TPB. Keenam konstruk tersebut adalah kemudahan pengguna persepsian (perceived ease of use/PEOU), kegunaan persepsian (perceived usefulness/PU), sikap terhadap penggunaan teknologi (attitude towards using technology/ATU), norma subyektif (subjectivenorm/SN), kontrol perilaku persepsian (perceived behavior control/PBC), dan minat perilaku menggunakan teknologi (behavioral intention to use/BIUS). Model gabungan ini selanjutnya digunakan untuk meneliti Program ICT EQEP yang merupakan teknologi e-learning yang digunakan di SMP penerima Program ICT EQEP. Penelitian ini selanjutnya akan menjelaskan tentang hubungan antar faktor-faktor yang mempengaruhi penerimaan dan penggunaan Program ICT EQEP di SMP penerima Program ICT EQEP.Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian eksplanatori dengan teknik analisis data menggunakan pendekatan SEM. Data diperoleh dari responden yang merupakan guru SMP atau user penerima Program ICT EQEPdi Kulon Progo dengan menyebarkan kuesioner tertutup. Terdapat 126 sampel penelitian yang dianalisis menggunakan metode SEM dengan software AMOS.Berdasarkan hasil analisis data diperoleh hasil sebagai berikut: (1) Konstruk PEOU mempengaruhi konstruk PU; (2) Konstruk PU mempengaruhi konstruk ATU; (3) Konstruk PEOU tidak memiliki pengaruh terhadap konstruk ATU; (4) Konstruk PU tidak memiliki pengaruh terhadap konstruk BIUS; (5) Konstruk ATU mempengaruhi konstruk BIUS; (6) Konstruk SN memiliki pengaruh terhadap konstruk BIUS; dan (7) Konstruk PBC mempengaruhi konstruk BIUS. Selain itu koefisien variabel laten PU terhadap ATU memiliki nilai paling besar diantara nilai koefisien variabel laten pada model hubungan antar konstruk lainnya. Kemudahan penggunaan persepsian (PEOU) di Kulon Progo masih tergolong cukup dan cenderung rendah dengan perentase 70,63%, Sikap terhadap penggunaan teknologi (ATU) sebagian besar guru sebagai user program ICT EQEP di Kulon Progo cenderung cukup tinggi sebesar 75,40%, Tingkat Kepercayaan (PU) sebagian besar guru sebagai user program ICT EQEP di Kulon Progo bahwa penggunaan teknologi akan meningkatkan kinerja pekerjaanya cenderung cukup tinggi sebesar 69,84%. Persepsi dan konstruk-konstruk internal dan eksternal dari perilaku (PBC) sebagian besar guru sebagai user program ICT EQEP di Kulon Progo cenderung tinggi sebesar 89,69%. Persepsi atau pandangan (SN) sebagian besar guru sebagai user program ICT EQEP di Kulon Progo terhadap kepercayaan-kepercayaan orang lain sebagai pertimbangan dalam melakukan sesuatu cenderung rendah sebesar 49,21%Kata kunci: Technology Acceptance Model (TAM), Theory of Planned Behavior (TPB), Program ICT EQEP, dan AMOS
OPTIMALISASI PENGOPERASIAN PEMBANGKIT LISTRIK TENAGA MIKROHIDRO (PLTMH) BERBASIS MASYARAKAT Di BANGKA BELITUNG (Pilot Project KemenESDM 2014)
Authors: Sabdullah Mursid 
Published: October 2021

Pembangkit listrik tenaga mikrohidro (PLTMH) merupakan salah satu pemanfaatan sumber energi alternative baru dan terbarukan. Hal ini sejalan dengan UU No. 30 Tahun 2007 tentang Energi dan Kebijakan Energi Nasional (KEN) yang tertuang dalam Perpres No 5 Tahun 2006 dan Inpres No 1 tahun 2006, yang salah satu tujuannya adalah untuk mencapai pembangunan PLTMH 0,1% dari Bauran Energi Nasional pada tahun 2025. Namun, saat ini di Bangkabelitung masih ada PLTMH yang tidak berfungsi secara optimal karena kurangnya pengetahuan masyarakat tentang teknologi, pemeliharaan dan pengelolaan PLTMH sehingga tidak tercapainya rasio pembangkit terhadap beban yang ideal. Oleh sebab itu dibutuhkan suatu upaya pemberdayaan masyarakat dalam bidang teknologi, pemeliharaan dan pengelolaan PLTMH sehingga dapat dicapai Optimalisasi Pengoperasian PLTMH berbasis masyarakat di Bangkabelitung. Kata kunci: renewable energy; microhydro; optimalisation
Rancang Bangun Sistem E-Learning di SMA Negeri 2 Magelang
Authors: Nurkhayati Ida 
Published: October 2021

INTISARIPemanfataan teknologi informasi dan komunikasi (ICT) terus digalakkan di SMA Negeri 2 Magelang, dengan tujuan agar dapat menunjang kegiatan belajar mengajar. Hal ini sesuai dengan visi dan misi yang dicanangkan sekolah. Dalam penelitian ini dikembangkan sebuah rancangan bangun sistem ­E-Learning yang diharapkan dapat mengefektifkan proses belajar mengajar. Pada proses pengembangan sistem, tahapan analisis yang dilakukan meliputi analisis sistem yang berjalan, analisis kelemahan sistem menggunakan metode SWOT serta analisis kebutuhan sistem. Kemudian dilanjutkan dengan tahapan perancangan. Tahapan perancangan dilakukan menggunakan pendekatan berbasis proses. Alat bantu pemodelan yang digunakan adalah DFD dan ERD. Rancangan yang telah dbuat selanjutnya diimplementasikan menggunakan bahasa pemrograman PHP dengan database MySQL.Sistem yang dibangun dalam penelitian ini dapat diaplikasikan secara online maupun secara offline. Dengan user interface yang mudah dipahami dan digunakan, diharapkan sistem yang dihasilkan dapat digunakan secara optimal, sehingga dapat membantu siswa dalam memahami mata pelajaran yang diberikan oleh para guru.Kata Kunci – E-Learning, PHP, MySQL, SWOT. ABSTRACTUtilization of information and communication technology (ICT) continues to be encouraged in SMA Negeri 2 Magelang, with the aim to support teaching and learning activities. This is in accordance with the vision and mission that proclaimed the school. In this study has been developed a design of the E-Learning system that is expected to streamline the teaching and learning process.In the process of system development, the stages of analysis includes the analysis of running systems, the analysis of system weaknesses using the SWOT method and system requirements analysis. Then proceed with the design stage. Stages of design was done using a process-based approach. The modeling tools used are DFD and ERD. The design that has been made then be implemented using PHP programming language with MySQL database.The system built in this research can be applied online or offline. With a user interface that is easy to understand and use, it is expected that the resulting system can be used optimally, so it can help students in understanding the subjects provided by the teachers.Keywords – E-Learning, PHP, MySQL, SWOT.
DIAGNOSA PENYAKIT PADA KAMBING DENGAN SISTEM PAKAR BERBASIS ANDROID
Authors: Setyawan Muhammad Rizki , Slameto Andika Agus 
Published: October 2021

INTISARIPengetahuan yang kurang akan penyakit pada kambing ditengah masyarakat dalam upaya identifikasi awal penyakit mempengaruhi pengambilan keputusan secara mandiri. Ketergantungan terhadap pengetahuan seorang pakar atau dokter hewan sangatlah tinggi, tetapi keberadaannya tidak selalu ada dan sangat susah ditemui, terutama di daerah pedesaan. Ditambah dengan masalah biaya dan sangat tidak efisien dari segi waktu.Oleh karena itu dalam penelitian ini dirancang sebuah sistem pakar dengan metode forward chaining yang merupakan teknik pencarian dimulai dari fakta yang diketahui, kemudia mencocokkan fakta-fakta tersebut dengan bagian IF dari rule IF-THEN. Bila ada fakta yang cocok dengan bagian IF, maka rule tersebut dieksekusi sebagai penarik kesimpulan untuk mendiagnosa penyakit pada kambing.Aplikasi sistem pakar dibuat berbasis Android karena penggunanya yang banyak dan dapat mudah digunakan dimana saja dan kapan pun. Diharapkan aplikasi dapat memberikan solusi dan penanganan sementara pada ternak berupa panduan untuk mengantisipasi terjadinya kematian pada kambing sebelum ditanyakan langsung kepada seorang pakar untk penanganan lebih lanjut.Dengan adanya sistem pakar untuk diagnose penyakit pada kambing berbasis android ini maka memudahkan peternak dalam melakukan tindakan yang diperlukan secara tepat dalam menangani penyakit pada kambing.Kata kunci: Android, penyakit, sistem pakar, forward chaining, kambing, android, mobile ABSTRACTLow knowledge of goat disease in the community in an attempt to identify early disease affects decision-making independently. Dependence on the knowledge of an expert or veterinarian is very high, but its existence is not always present and very difficult to find, especially in rural areas. Coupled with cost issues and very inefficient in terms of time.Therefore in the study designed an expert system with forward chaining method which is a search technique starting from known facts, then match those facts with the IF part of the IF-THEN rule. If there are facts that match the IF section, then the rule is executed as a conclusion to diagnose the disease in goats.Expert system applications are made based on Android because of its many users and can be easy to use anywhere and anytime. It is expected that the application can provide solutions and temporary handling of livestock in the form of a guide to anticipate the occurrence of death in goats before being asked directly to an expert for further handling.With the expert system for diagnosis of disease in goats android-based this makes it easier for farmers in performing the necessary actions appropriately in dealing with disease in goats.Keywords : android, disease, expert system, forward chaining, goat, android, mobile.
PREDIKSI KELULUSAN MAHASISWA MAGISTER TEKNIK INFORMATIKA UNIVERSITAS AMIKOM YOGYAKARTA MENGGUNAKAN METODE K-NEAREST NEIGHBOR
Authors: Susanto Eri Sasmita , Kusrini Kusrini , Fatta Hanif Al 
Published: October 2021

INTISARIPenelitian ini difokuskan untuk mengetahui uji kelayakan prediksi kelulusan mahasiswa Universitas AMIKOM Yogyakarta. Dalam hal ini penulis memilih algoritma K-Nearest Neighbors (K-NN) karena K-Nearest Neighbors (K-NN) merupakan algoritma yang bisa digunakan untuk mengolah data yang bersifat numerik dan tidak membutuhkan skema estimasi parameter perulangan yang rumit, ini berarti bisa diaplikasikan untuk dataset berukuran besar.Input dari sistem ini adalah Data sampel berupa data mahasiswa tahun 2014-2015. pengujian pada penelitian ini menggunakn dua pengujian yaitu data testing dan data training. Kriteria yang digunakan dalam penelitian ini adalah , IP Semester 1-4, capaian SKS, Status Kelulusan. Output dari sistem ini berupa hasil prediksi kelulusan mahasiswa yang terbagi menjadi dua yaitu tepat waktu dan kelulusan tidak tepat waktu.Hasil pengujian menunjukkan bahwa Berdasarkan penerapan k=14 dan k-fold=5 menghasilkan performa yang terbaik dalam memprediksi kelulusan mahasiswa dengan metode K-Nearest Neighbor menggunakan indeks prestasi 4 semester dengan nilai akurasi= 98,46%, precision= 99.53% dan recall =97.64%.Kata kunci: Algoritma K-Nearest Neighbors, Prediksi Kelulusan, Data Testing, Data Training ABSTRACTThis research is focused on knowing the feasibility test of students' graduation prediction of AMIKOM University Yogyakarta. In this case the authors chose the K-Nearest Neighbors (K-NN) algorithm because K-Nearest Neighbors (K-NN) is an algorithm that can be used to process data that is numerical and does not require complicated repetitive parameter estimation scheme, this means it can be applied for large datasets.The input of this system is the sample data in the form of student data from 2014-2015. test in this research use two test that is data testing and training data. The criteria used in this study are, IP Semester 1-4, achievement of SKS, Graduation Status. The output of this system in the form of predicted results of student graduation which is divided into two that is timely and graduation is not timely.The result of the test shows that based on the application of k = 14 and k-fold = 5, the best performance in predicting the students' graduation using K-Nearest Neighbor method uses 4 semester achievement index with accuracy value = 98,46%, precision = 99.53% and recall = 97.64%.Keywords: K-Nearest Neighbors Algorithm, Graduation Prediction, Testing Data, Training Data