bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between schizophrenia and periodontal disease in relation to cortisol levels: an ELISA-based descriptive analysis
Authors: Albahli Bariah Fahad , Alrasheed Najd Mohammed , Alabdulrazaq Raghad Saleh , Alasmari Dhafer S. , Ahmed Muzammil Moin 
Published: December 2021

Abstract
Background
Schizophrenia is a chronic psychosis marked by multiple bioenvironmental and immunological dysregulation with its intricate role in etiopathogenesis of periodontal disease remaining unclear. Hence, the aim of this study is to determine the association between periodontal disease and schizophrenia in relation with cortisol levels.

Methods
The study is in descriptive design comprised of 40 subjects randomly selected (20 schizophrenic patients as Group A and 20 healthy volunteers as group B). All the study participants underwent complete periodontal examination including scoring of gingival index (GI), plaque index (PI), Probing depths (PD) and clinical attachment loss (CAL). Salivary cortisol levels are estimated using ELISA. Link between schizophrenia and periodontal disease is described in relation to cortisol levels with elimination of other shared risk factors, such as tobacco smoking and xerostomia.

Results
Significant higher values of periodontal parameters are observed in Group A with schizophrenic patients (GI 2.467 ± 0.528; PI 2.402 ± 0.526; PD 2.854 ± 0.865; CAL 1.726 ± 3.096) than Group B with healthy subjects (GI 0.355 ± 0.561; PI 0.475 ± 0.678; PD 1.493 ± 0.744; CAL 0.108 ± 0.254). However, cortisol levels are lower in schizophrenic group (0.190 ± 0.059) than non-schizophrenic group (0.590 ± 0.228) ruling out the possible role of cortisol in periodontal disease severity associated with schizophrenic patients.

Conclusion
Findings of this study, provides ground evidence for consideration of schizophrenia as a risk factor for periodontitis and demands greater emphasis on management of schizophrenic patients in dental setting similar to other comorbid disorders such as diabetes mellitus and also incorporating periodontal care measures in the clinical guidelines for schizophrenia management.
Erosive acute colitis associated with intestinal spirochetosis
Authors: de Paula Fabio Dantas , de Abreu Glicia Estevam , de Souza Maiara Ferreira , de Freitas Luiz Antonio Rodrigues , Athanazio Daniel Abensur 
Published: December 2021

Abstract
Background
Although usually believed to be harmless, intestinal spirochetosis may active erosive colitis associated with intestinal spirochetosis that may mimic idiopathic chronic inflammatory bowel disease. Case presentation. A 49-year-old homosexual male patient sought medical assistance due to asthenia, rectal bleeding, tenesmus, and diarrhea for one month. He had been using corticosteroids for nine months to treat sciatic nerve pain. Colonoscopy showed rectum and distal sigmoid with diffuse erythema with many surface erosions. Rectal biopsy showed inflammatory changes including chronic changes such as architectural distortion and basal plasmacytosis, and active inflammation including crypt microabscesses. In all large bowel sample, dense colonization of intestinal spirochetosis was observed. Patient also had a positive PCR testing for Chlamydia trachomatis. The patient was treated with metronidazole for 14 days, ciprofloxacin for 14 days and azithromycin (single dose). Symptoms improved and the patient is asymptomatic after two months of follow-up.

Conclusion
In some high-risk groups, intestinal spirochetosis may cause colonic manifestations with overlapping features with intestinal bowel diseases. Awareness of this association is importance since proper antibiotic therapy against Brachyspira (metronidazole) is highly effective. Coinfection with other sexually transmitted infections is common and proper treatment is required.
Evaluation of the effects of sound exposure and low field electromagnetism on growth and antibiotics susceptibility of some microorganisms
Authors: Garuba Emmanuel Oluwaseun , Ajunwa Obinna Markraphael , Ibrahim-King Aishat Nana 
Published: December 2021

AbstractBackgroundThe emergence of antibiotic-resistant microorganisms has been largely associated with drug misuse, drug abuse, and indiscriminate disposal of drugs; however, the interactions between some environmental factors and antibiotic resistance by microorganisms have been understudied. In this study, the effects of sound and electromagnetic field on the growth and antibiotic susceptibility of selected microorganisms to antibiotics were investigated.ResultsMicroorganisms used includeGluconobacter oxydansATCC 19,357,Rhodobacter sphaeroidesATCC 17,023,Citrobacter freundiiATCC 33,128,Yersina pestisATCC 11,953,Bacillus subtilis6633,Acetobacter acetiATCC 15,973,Escherichia coliATCC 25,922,Pseudomonas aeuriginosaATCC 9027,Streptococcus pyogenesATCC 19,613,Klebsiella pneumoniaATCC 25,955,Staphylococcus aureusATCC 25,923 andSerratia marcescensATCC 14,766. The antibiotics used were: Ciprofloxacin 5 μg, Imipenem 10 μg, Ampicillin 10 μg, Ceftazidime 30 μg and Tetracycline 30 μg for Gram-negative bacteria while Pefloxacin 10 μg, Gentamycin 10 μg, Amplicillin + Cloxacillin 30 μg, Cefuroxime 20 μg, Amoxacillin 30 μg, Ceftriaxone 25 μg, Ciprofloxacin 10 μg, Streptomycin 30 μg, Co-trimoxazole 30 μg, and Erythromycin 10 μg for Gram-positive bacteria, respectively. Acoustic treatment had varying effects on the antibiotics susceptibility profile of all test bacterial culture. Before exposure, P. aeruginosahad the highest zone of inhibition of 34 ± 3.4 mm, whileB. subtilis had least inhibition zone of 12 ± 2.8. After exposure to acoustic treatment at 5000 Hz/90 dB at 72 h, C. freundiihad highest zone of inhibition of 32 ± 0.7 mm and the least zone of 11 ± 1.4 mm observed inP. aeruginosa. At 1125 Hz/80 dB after 72 h,R. sphaeroideshad highest zone of 34 ± 0.7 mm while A. acetihad least zone of inhibition of 10 ± 0 mm. Effect of electromagnetic flux treatment of 15 min showedE. colito be the most inhibited having a growth rate of 0.08 log cfu/mL, antibiotics testing showedG. oxydansto have the highest zone of inhibition of 28 ± 3.5 mm and least zone was observed inB. subtilis having a zone of 13 ± 2.8 mm.ConclusionThis study showed that environmental factor such as sound and electromagnetic flux (EMF) could interfere with the physiology of bacteria including resistance/susceptibility to antibiotics. However, further investigation will be needed to understand full mechanisms of action of sound and electromagnetic field on bacteria.
The protective role of vitamin C in the management of COVID-19: A Review
Authors: Uddin Mohammad Sarowar , Millat Md. Shalahuddin , Baral Prodip Kumar , Ferdous Mahmuda , Uddin Md. Giash , Sarwar Md. Shahid , Islam Mohammad Safiqul 
Published: December 2021

Abstract
Background
The outbreak of coronavirus infectious disease-2019 (COVID-19) is globally deemed a significant threat to human life. Researchers are searching for prevention strategies, mitigation interventions, and potential therapeutics that may reduce the infection’s severity. One such means that is highly being talked in online and in social media is vitamin C.

Main text
Vitamin C is a robust antioxidant that boosts the immune system of the human body. It helps in normal neutrophil function, scavenging of oxidative species, regeneration of vitamin E, modulation of signaling pathways, activation of pro-inflammatory transcription factors, activation of the signaling cascade, regulation of inflammatory mediators, and phagocytosis and increases neutrophil motility to the site of infection. All of these immunological functions are required for the prevention of COVID-19 infection.

Conclusion
Considering the role of vitamin C, it would be imperative to administrate vitamin C for the management of severe COVID-19. However, there is no specific clinical data available to confirm the use of vitamin C in the current pandemic.
Ergonomic risk factors and musculoskeletal disorders in bank staff: an interventional follow-up study in Iran
Authors: Motamedzadeh Majid , Jalali Mahdi , Golmohammadi Rostam , Faradmal Javad , Zakeri Hamid Reza , Nasiri Iman 
Published: December 2021

Abstract
Background
Long-term use of computer in a static mode may cause musculoskeletal disorders (MSDs) in bank staff. Considering the high number of bank employees in different countries, such as Iran, the risk factors of these disorders should be investigated in order to implement interventions required to reduce the risk factors. This study aimed to examine the risk factors of MSDs using the Rapid Office Strain Assessment (ROSA) method and to perform an ergonomic intervention program with banking staff in Iran.

Methods
This interventional study was conducted on 277 bank employees in Iran. Subjects were randomly divided into three groups, including a control group (without any intervention), an educational intervention (EI) group, and a group receiving both educational and physical intervention (EPI). Before and after the intervention, the ROSA method and Nordic questionnaire were used to assess the risk factors of MSDs in office jobs and to investigate the prevalence of MSDs. Data were collected 2 weeks before and 9 months following the intervention.

Results
Before the intervention, the mean score of ROSA at workstations of all groups was above five with high risk. Nine months after the start of the intervention, there was a significant decrease in the mean ROSA score and its components in the two groups that received the intervention, which was statistically significant (P < 0.001). The results of the study of the prevalence of MSDs in the employees—before the intervention—indicate that the highest prevalence of MSDs in the control group was in areas of the neck (67.1%), back (64.4%), and lower back (63%). In the EI group, the highest prevalence of MSDs was in the neck (65.2%), lower back (61.6%), and back (60.7%) areas. In the EPI group, the discomfort areas were the neck (68.5%), shoulders (66.3%), and lower back (60.9%). Nine months after the intervention, there was a significant decrease in the prevalence of MSDs in the neck, shoulders, and lumbar regions of staff who received the intervention (P < 0.05).

Conclusion
Nine months after performing the interventions, there was a relative improvement in workstations and prevalence of MSDs in various areas within the bodies of the bank staff. This study showed that using the ROSA method is appropriate for assessing the risk factors of office work and that it can identify deficiencies in workstations. These defects can be addressed by designing and implementing an EI program together with physical interventions according to the components of the ROSA method.
Good soldiers in implementation: validation of the Implementation Citizenship Behavior Scale and its relation to implementation leadership and intentions to use evidence-based practices
Authors: Borge Randi Hovden , Skar Ane-Marthe Solheim , Endsjø Mathilde , Egeland Karina M. 
Published: December 2021

Abstract
Background
Implementation citizenship behavior (ICB) describes extra-role behaviors performed by employees to support evidence-based practice (EBP) implementation. Such behaviors can be measured using the Implementation Citizenship Behavior Scale (ICBS), which divides ICB into two dimensions, namely helping others and keeping informed. The current study extends the use of the ICBS to a context outside the USA and adds to the literature by investigating how leader-perceived ICB relates to practitioner-perceived implementation leadership and practitioners’ intentions to use EBPs.

Methods
Participants were 42 leaders and 152 practitioners in Norwegian mental health services implementing EBPs for post-traumatic stress disorder. Leaders rated each practitioner on ICB, and each practitioner rated their leader on implementation leadership and reported on their own intentions to use EBPs. The psychometric properties of the ICBS were assessed using confirmatory factor analysis and internal consistency reliabilities. The relationships between ICB, implementation leadership and intentions to use EBPs, were investigated through a series of bivariate correlation analyses and a path analysis of the total scales.

Results
The ICBS showed excellent psychometric properties. The hypothesized two-factor model provided an excellent fit to the data, and both subscales and the total scale were internally reliable. Leader-perceived ICB was positively and significantly correlated with both practitioner-perceived implementation leadership and practitioners’ intentions to use EBPs. Correlations with intentions to use EBPs were stronger for the subscale of keeping informed than for the subscale of helping others.

Conclusions
Results indicated that practitioners who rated their leader higher on implementation leadership received higher ICB ratings from their leader and reported higher intentions to use EBPs. The results provide evidence of a reciprocal social exchange relationship between leaders and practitioners during EBP implementation and a link to an important proximal implementation outcome (i.e., intentions to use EBPs). Results also suggest cultural differences in how ICB is perceived and relates to other phenomena. Scientific and practical implications are discussed.

Trial registration
Retrospectively registered in ClinicalTrials with ID NCT03719651.
Implementation of evidence-based guidance for dementia palliative care using participatory action research: examining implementation through the Consolidated Framework for Implementation Research (CFIR)
Authors: Coffey Alice , Hartigan Irene , Timmons Suzanne , Buckley Catherine , Lehane Elaine , O’Loughlin Christina , O’Connell Selena , Cornally Nicola 
Published: December 2021

Abstract
Background
The importance of providing evidence-based palliative care for people with dementia is increasingly acknowledged as important for patient outcomes. In Ireland, evidence-based guidance has been developed in order to address key features of dementia palliative care, including the management of pain, medications and hydration and nutrition. The aim of this study was to identify and explore the factors affecting the implementation of evidence-based guidance on dementia palliative care.

Methods
The Consolidated Framework for Implementation (CFIR) guided a mixed-method pre-post study. One guidance document pertaining to the management of pain, medication or hydration and nutrition was implemented in three long-term care facilities. Participatory action research in the form of work-based learning groups was used to implement the guidance, drawing on a situational analysis (pre-implementation). Staff questionnaires and audits were conducted pre- and post-implementation while champion interviews were also conducted post-implementation.

Results
Features of the guidance, the inner setting components such as readiness to change, and the process of implementation were most frequently identified as impacting implementation. Components of the outer setting, such as external policy incentives and individual characteristics, featured less commonly. Data from qualitative interviews revealed that the guidance was perceived as advantageous or complimentary to previous care provided. Within the inner setting, leadership and support from other colleagues facilitated implementation. However, limited availability of other healthcare professionals to assist with carrying out guidance actions presented a barrier in some facilities. The external facilitators of the work-based learning groups (WBLGs) were perceived as experienced and encouraged active participation and reflection on practices. Despite the challenge of releasing staff to attend the WBLGs, quantitative data demonstrated reduced staff de-motivation amongst those who did attend was noted post-implementation (pre-Mdn = 19.50 versus post-Mdn = 22.00, U = 497.00, p = 0.07).

Conclusions
A situational analysis informed by the CFIR framework in conjunction with a participatory action research approach helped to advance the implementation of the guidance. The progress of implementation depended on the extent to which evidence-based care was previously being implemented at each site. Post-implementation analysis using CFIR identified challenges to address in future projects such as staff cover and timing of training to facilitate attendance for staff with different working hours. Facilitators included multidisciplinary engagement with the intervention and champions at each site to support the implementation process.
Angiopoietin-2 as a predictor of fibrosis regression in chronic hepatitis C virus patients after direct-acting antiviral drugs
Authors: Isaac Amira , El Sakaty Tarek Maged , Hussein Sarah Hamdan , Rasmy Hany Samir 
Published: December 2021

Abstract
Background
HCV infection is a major health concern. Disease progression to fibrosis, cirrhosis, and HCC is aided by the persistence of inflammatory reactions and cellular damage. Moreover, angiogenesis was found to have a substantial pathogenic role in disease progression. Serum Angiopoietin-2 appears to be correlated with liver stiffness in chronic HCV and its elevation is linked to disease progression from chronic hepatitis to cirrhosis. The aim of this study was to evaluate the role of serum Angiopoietin-2 in the prediction of regression of fibrosis in chronic HCV patients receiving direct-acting antiviral agents. Forty Egyptian chronic HCV patients for whom direct-acting antiviral agent (DAA) therapy was planned were included. All patients underwent assessment twice, at baseline and at SVR12, for standard laboratory tests, measurement of fibrosis using FibroScan, FIB-4 and APRI scores, and Angiopoietin-2 level.

Results
Statistically significantly higher levels of baseline Ang-2 were detected with the progression of fibrosis stages with a p-value of <0.001. The best cutoff value of baseline Ang-2 in discrimination of liver cirrhosis (F4) from F0-F3 was > 630 pg/ml with 85.71% sensitivity and 84.85% specificity. A statistically significant decline of Ang-2 (from 464.3±237.2 pg/ml to 401.3±277.1 pg/ml) was noted after the achievement of SVR12 with a p-value < 0.001. Regression of liver fibrosis in this study is defined as a decrease of more than or equal to one stage in liver fibrosis. Lower baseline fibrosis stages and other non-invasive scoring systems (FIB-4 and APRI scores) were associated with regression of fibrosis following successful DAAs treatment. However, higher baseline Ang-2 levels were significantly associated with non-regression of fibrosis, and at a cutoff of >680 pg/ml, it might predict non-regression of fibrosis after successful eradication of HCV with DAAs with 93.33% sensitivity and 70% specificity.

Conclusions
Angiopoietin-2 can be a useful predictor of fibrosis regression in chronic HCV patients receiving direct-acting antiviral agents. Elevated baseline Angiopoietin-2 and advanced fibrosis stages may predict non-regression of liver fibrosis.
Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients
Authors: Gharbia Ola Mohammad , Bassiouni Sherine Abdel Rahman , Zaki Maysaa El Sayed , El-Beah Shimaa Mohsen , El-Desoky Manal Mohamed , Elmansoury Eman Adel , Abdelsalam Mostafa 
Published: December 2021

Abstract
Background
Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN) in Egyptian patients.

Results
The C allele and homozygous CC genotype of the TLR9-rs352140 in co-dominant and recessive models were more prevalent in SLE patients than controls (P = 0.047, P = 0.017, and P = 0.005 respectively). In contrast, allelic and genotyping distribution of TLR5-rs5744168 and TLR9-rs187084 SNPs showed no association with the risk of SLE. The T allele of the TLR5-rs5744168 was more prevalent in LN patients than controls (P = 0.021). The homozygous TT genotype of TLR5-rs5744168 SNP was more prevalent in LN patients in the co-dominant and the recessive models than controls (P = 0.036 and P = 0.011 respectively). The C allele of the TLR9-rs352140 was more prevalent in LN patients than controls (P = 0.015). The homozygous CC genotype of the TLR9-rs352140 SNP was more prevalent in LN than controls in co-dominant and recessive models (P = 0.002 and P < 0.001). In the recessive model of the TLR5-rs5744168 SNP, the TT genotype was found in 3.2% of the SLE patients while none of the SLE patients without LN or controls had TT genotype (P = 0.036). Also, in the recessive model of the TLR9-rs352140 SNP, the CC genotype was significantly more frequent in SLE patients with LN than without LN (44.4% vs 29.9%, P = 0.045).

Conclusion
Our results support the potential role of TLR5-rs5744168 SNP and TLR9-rs3532140 SNP not only in increasing the risk for development of SLE, but also in increasing the risk of LN in SLE patients among the Egyptian population.
Incorporating terrain specific beaching within a lagrangian transport plastics model for Lake Erie
Authors: Daily Juliette , Onink Victor , Jongedijk Cleo E. , Laufkötter Charlotte , Hoffman Matthew J. 
Published: December 2021

AbstractMass estimates of plastic pollution in the Great Lakes based on surface samples differ by orders of magnitude from what is predicted by production and input rates. It has been theorized that a potential location of this missing plastic is on beaches and in nearshore water. We incorporate a terrain dependent beaching model to an existing hydrodynamic model for Lake Erie which includes three dimensional advection, turbulent mixing, density driven sinking, and deposition into the sediment. When examining parameter choices, in all simulations the majority of plastic in the lake is beached, potentially identifying a reservoir holding a large percentage of the lake’s plastic which in previous studies has not been taken into account. The absolute amount of beached plastic is dependent on the parameter choices. We also find beached plastic does not accumulate homogeneously through the lake, with eastern regions of the lake, especially those downstream of population centers, most likely to be impacted. This effort constitutes a step towards identifying sinks of missing plastic in large bodies of water.