bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation analysis of the novel imaging-based prognostic radiomic signature in patients undergoing primary surgery for advanced high-grade serous ovarian cancer (HGSOC)
Authors: Fotopoulou Christina , Rockall Andrea , Lu Haonan , Lee Philippa , Avesani Giacomo , Russo Luca , Petta Federica , Ataseven Beyhan , Waltering Kai-Uwe , Koch Jens Albrecht , Crum William R. , Cunnea Paula , Heitz Florian , Harter Philipp , Aboagye Eric O. , du Bois Andreas , Prader Sonia 
Published: December 2021

Abstract
Background
Predictive models based on radiomics features are novel, highly promising approaches for gynaecological oncology. Here, we wish to assess the prognostic value of the newly discovered Radiomic Prognostic Vector (RPV) in an independent cohort of high-grade serous ovarian cancer (HGSOC) patients, treated within a Centre of Excellence, thus avoiding any bias in treatment quality.

Methods
RPV was calculated using standardised algorithms following segmentation of routine preoperative imaging of patients (n = 323) who underwent upfront debulking surgery (01/2011-07/2018). RPV was correlated with operability, survival and adjusted for well-established prognostic factors (age, postoperative residual disease, stage), and compared to previous validation models.

Results
The distribution of low, medium and high RPV scores was 54.2% (n = 175), 33.4% (n = 108) and 12.4% (n = 40) across the cohort, respectively. High RPV scores independently associated with significantly worse progression-free survival (PFS) (HR = 1.69; 95% CI:1.06–2.71; P = 0.038), even after adjusting for stage, age, performance status and residual disease. Moreover, lower RPV was significantly associated with total macroscopic tumour clearance (OR = 2.02; 95% CI:1.56–2.62; P = 0.00647).

Conclusions
RPV was validated to independently identify those HGSOC patients who will not be operated tumour-free in an optimal setting, and those who will relapse early despite complete tumour clearance upfront. Further prospective, multicentre trials with a translational aspect are warranted for the incorporation of this radiomics approach into clinical routine.
Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation
Authors: Soroosh Artin , Fang Kai , Hoffman Jill M. , Law Ivy K. M. , Videlock Elizabeth , Lokhandwala Zulfiqar A. , Zhao Jonathan J. , Hamidi Sepehr , Padua David M. , Frey Mark R. , Pothoulakis Charalabos , Rankin Carl R. 
Published: December 2021

AbstractWhile apoptosis plays a significant role in intestinal homeostasis, it can also be pathogenic if overactive during recovery from inflammation. We recently reported that microRNA-24-3p (miR-24-3p) is elevated in the colonic epithelium of ulcerative colitis patients during active inflammation, and that it reduced apoptosis in vitro. However, its function during intestinal restitution following inflammation had not been examined. In this study, we tested the influence of miR-24-3p on mucosal repair by studying recovery from colitis in both novel miR-24-3p knockout and miR-24-3p-inhibited mice. We observed that knockout mice and mice treated with a miR-24-3p inhibitor had significantly worsened recovery based on weight loss, colon length, and double-blinded histological scoring. In vivo and in vitro analysis of miR-24-3p inhibition in colonic epithelial cells revealed that inhibition promotes apoptosis and increases levels of the pro-apoptotic protein BIM. Further experiments determined that silencing of BIM reversed the pro-apoptotic effects of miR-24-3p inhibition. Taken together, these data suggest that miR-24-3p restrains intestinal epithelial cell apoptosis by targeting BIM, and its loss of function is detrimental to epithelial restitution following intestinal inflammation.
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection
Authors: Liu Jiaojiao , Xu Kun , Xing Man , Zhuo Yue , Guo Jingao , Du Meng , Wang Qi , An Yaling , Li Jinhe , Gao Ping , Wang Yihan , He Furong , Guo Yingying , Li Mingxi , Zhang Yuchao , Zhang Linqi , Gao George F. , Dai Lianpan , Zhou Dongming 
Published: December 2021

AbstractA safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed to tackle the COVID-19 global pandemic. Here, we describe the development of chimpanzee adenovirus serotypes 6 and 68 (AdC6 and AdC68) vector-based vaccine candidates expressing the full-length transmembrane spike glycoprotein. We assessed the vaccine immunogenicity, protective efficacy, and immune cell profiles using single-cell RNA sequencing in mice. Mice were vaccinated via the intramuscular route with the two vaccine candidates using prime-only regimens or heterologous prime-boost regimens. Both chimpanzee adenovirus-based vaccines elicited strong and long-term antibody and T cell responses, balanced Th1/Th2 cell responses, robust germinal center responses, and provided effective protection against SARS-CoV-2 infection in mouse lungs. Strikingly, we found that heterologous prime-boost immunization induced higher titers of protective antibodies, and more spike-specific memory CD8+ T cells in mice. Potent neutralizing antibodies produced against the highly transmissible SARS-CoV-2 variants B.1.1.7 lineage (also known as N501Y.V1) and B.1.351 lineage (also known as N501Y.V2) were detectable in mouse sera over 6 months after prime immunization. Our results demonstrate that the heterologous prime-boost strategy with chimpanzee adenovirus-based vaccines is promising for further development to prevent SARS-CoV-2 infection.
Improved generalised integrator for optimal dispatch of SyRG‐based pico‐hydro‐PV system
Authors: Sharma Rohini , Singh Bhim , Kewat Seema 
Published: December 2021

AbstractThe fluctuating outputs from renewable energy sources (RESs) and variable load power demand deteriorate the current quality, thus an improved generalised integrator with a frequency‐locked loop (IGI‐FLL) control strategy is used, which is not only easy but simple to attain a quick and precise fundamental extraction. IGI‐FLL control method is utilised with all‐pass filter and is capable to accomplish enhanced harmonics, noise and DC offset rejection ability while estimating fundamental component of the load current. In addition, the FLL structure is used to increase the frequency immunity against voltage variations. It provides improved steady‐state and dynamic performances with flexibility in parameter tuning in comparison to SOGI‐FLL algorithm. It also presents a cost‐effective and robust genetic algorithm (GA)‐based optimisation to provide optimum battery charging and discharging power while satisfying the state‐of‐charge (SOC) limits under RES uncertainty. In this islanded microgrid, a Synchronous Reluctance Generator for pico‐hydro and photovoltaic array is used so that this hybrid system utilises maximum solar PV array power, matches the load, or else charges the battery energy storage while maintaining power balance in the microgrid. Comparative outcomes authenticate the efficacy of the algorithm to handle the issue of RES uncertainty and load unbalance in an islanded microgrid.
Electricity‐heat‐gas integrated demand response dependency assessment based on BOXCOX‐Pair Copula model
Authors: Tian Shuxin , Huang Wentao , Yan Taishan , Yang Xijun , Fu Yang 
Published: December 2021

AbstractWith the continuous development of Regional Integrated Energy System (RIES), demand response (DR) is composed of diversified loads including electric load, heat load and gas load. Their cross‐dependencies reflecting the nonlinear coupling complementary relationship between each load type are one of the key factors to improve multi‐energy flow optimisation modelling and utilisation efficiency on the demand side. Accordingly, this paper proposes a DR dependency assessment method considering electricity‐heat‐gas loads based on the BOXCOX‐Pair Copula model. BOXCOX transformation is introduced to convert various probability distribution statistics of electricity‐heat‐gas loads into Gaussian distributed variables. C‐vine Pair Copula is used to characterise an ensemble‐of‐trees of high‐dimensional dependency structure among multi‐energy demand modalities. Then the combined model of BOXCOX transformation and C‐vine Pair Copula can be employed to determine the complex coupling dependency among electricity‐heat‐gas loads according to different DR statistics. Some metrics between the original empirical distribution and BOXCOX‐Pair Copula distribution are introduced to assess the dependency evaluation precision of the proposed model. Finally, the novel dependency assessment model is numerically tested utilising the electricity load, heat load and gas load data sequences in a real RIES. The results illustrate that the cross‐dependency of electricity‐heat‐gas integrated DR based on the BOXCOX‐C‐vine copula model is closer to that of actual sample data, which verify the effectiveness and superiority of the proposed approach.
Veränderungen in der ICD-11: Störungen durch Substanzgebrauch und Verhaltenssüchte
Authors: Gutwinski Stefan , Heinz Andreas 
Published: December 2021

ZusammenfassungICD-11 unterscheidet 3 Formen des schädlichen Gebrauches und 5 Formen der Substanzabhängigkeit. Zudem werden laut einer Vorversion die bisherigen 6 Kriterien der Substanzabhängigkeit in 3 Doppelkriterien zusammengefasst. Die Formulierung des fortgesetzten Konsums „trotz eindeutig schädlicher Folgen“ soll durch „trotz des Auftretens von Problemen“ ersetzt werden. Pathologischen Glücksspielen und pathologischen Spielens werden als Verhaltenssüchte neben den substanzbezogenen Störungen aufgeführt.Die Reduktion der Diagnosekriterien der Substanzabhängigkeit von 6 auf 3 ist problematisch. Laut erster Studien kommt es unter Anwendung des ICD-11 zu häufigeren Diagnosen von Alkohol- und Cannabisabhängigkeit. Dass die Formulierung des Konsums „trotz eindeutig schädlicher Folgen“ durch „trotz des Auftretens von Problemen“ ersetzt werden soll, wäre problematisch, da dies auch juristische und soziale Probleme beinhalten kann und damit die Pathologisierung sozialer Probleme befördern könnte.
Häusliche Gewalt und Partnerschaftsgewalt – eine Herausforderung im Gesundheitssektor
Authors: Schellong Julia , Epple Franziska , Lorenz Patrick , Ritschel Gerhard , Croy Ilona , Lenk Maria , Maertens Gesine , Böhm Ulrike , Weidner Kerstin 
Published: December 2021

ZusammenfassungHäusliche Gewalt ist laut Studien gesundheitsgefährdend. Ärzt*innen werden von Gewaltopfern als primäre Ansprechpersonen wahrgenommen. Zur Prävention weiterer Gewalt interessiert deren Wahrnehmung von sich selbst als Schlüsselstelle. 1346 bei der Sächsischen Landesärztekammer 2015 gemeldete (Zahn-)Ärzt*innen beantworteten einen Fragebogen zum Kontakt mit Betroffenen, zu Hilfestrukturen und zu Fortbildungen zum Thema. Sie äußerten eine geringe Kontakthäufigkeit zu Betroffenen bei hoher Bereitschaft, Patient*innen bei Verdacht anzusprechen. Es fand sich Unsicherheit bei der Weitervermittlung sowie eingeschränkte Bekanntheit vorhandener Hilfestrukturen. Hohe Bereitschaft gab es für weitere Fortbildung. Zusammenfassend bestehen einerseits Motivation und Bereitschaft, andererseits Unsicherheit und Unkenntnis bezüglich der Thematik häusliche Gewalt und spezifische Hilfestrukturen. Fortbildungen mit Fokus auf zentrale Vernetzungsinhalte und Schnittstellen sollten Ärzt*innen bei der Wahrnehmung ihrer Rolle im Hilfesystem unterstützen.
Five-Year Long-Term Follow-Up of Selective Laser Trabeculoplasty in Open-Angle Glaucoma
Authors: Gack Christina , Laemmer Robert , Hohberger Bettina 
Published: December 2021

Abstract
Purpose Selective laser trabeculoplasty (SLT) is known as a safe laser therapy for an effective reduction in intraocular pressure (IOP). The aim of this study was to examine the
therapeutic success of SLT in open-angle glaucoma (OAG) patients with a long-term follow-up of 5 years.
Methods Forty-six eyes of forty OAG patients, some with previous intraocular surgery, underwent SLT (24 males, 16 females). Therapeutic success was categorized as: category (I) – IOP
reduction ≤ 21 mmHg and > 20% compared to baseline IOP with additional glaucoma medication; category (II) – IOP reduction ≤ 18 mmHg and > 30% compared to baseline IOP with additional
glaucoma medication; category (III) – IOP reduction ≤ 18 mmHg without any additional glaucoma medication at all follow-ups. Therapeutic failure was defined as the necessity of any further
glaucoma surgery (IV).
Results (1) SLT was well tolerated in all eyes, and no severe side effects or complications were recorded. (2) After 1-year follow-up, therapeutic success was 27% (I), 30% (II), and
3% (III). The therapeutic failure rate was 40% (IV). (3) After 2 years follow-up, therapeutic success was 7% (I), 10% (II), and 0% (III). The therapeutic failure rate was 83% (IV). (4) After
3 years follow-up, the therapeutic failure rate increased up to 100% (IV).
Conclusion SLT seemed to be effective in lowering IOP in the first year in the present cohort, however, the long-term effect is low and additional local therapy or surgical
interventions are necessary.
Rationale, Mission and Vision for a National Centre of Affective
Disorders in Germany
Authors: Reif Andreas , Baune Bernhard T. , Deckert Jürgen , Juckel Georg , Kittel-Schneider Sarah , Kircher Tilo , Kornhuber Johannes , Rupprecht Rainer , Bauer Michael 
Published: December 2021

AbstractAffective disorders are common, complex disorders representing one of the major
challenges to global health in the 21st century. To mitigate the burden of
disease, substantial public health efforts need to be undertaken since research
on the causes and adequate treatment requires multidisciplinary approaches.
These should integrate translational, and clinical research, aided by
technological advancements in collecting and analysing comprehensive data. Here
we present the rationale, concept, mission and vision of the recently founded
National Centre of Affective Disorders (NCAD) in Germany. NCAD founding partners
build on their previous successful cooperation within the German Research
Network for Mental Disorders funded by the Federal Ministry of Education and
Research (BMBF). They form an internationally pre-eminent network of integrative
excellence, leading in science and contributing significantly to the improved
care of affective disorder patients. The partners will provide complementary
structures and innovative methods across the entire translational continuum from
bench to clinical and real-world settings. The vision of the NCAD is to foster
cross-disciplinary research from basic neuroscience to public mental health by
close translational collaboration between academia, non-university research
institutions, and international partners, including industry, to deliver
cutting-edge research, innovative clinical services and evidence-based training
to young clinicians and scientists. The mission is to accomplish research in a
highly translational manner, especially with respect to clinical studies in a
trans-sectoral way. This approach aims to ensure continuous improvement in the
treatment and care provided to patients and an interdisciplinary environment for
high-level research and education in affective disorders.
Comparison of Techniques for Obtaining Centric Relation Based on the Reproducibility of the Condylar Positions in Centric Relation—A Systematic Review
Authors: de Moraes Melo Neto Clóvis Lamartine , dos Santos Daniela Micheline , de Magalhães Bertoz André Pinheiro , Moreno André Luiz de Melo , Goiato Marcelo Coelho 
Published: December 2021

AbstractThe objective of this systematic review was to compare centric relation (CR) techniques that belong to the same method of obtaining CR (guided, graphical, or physiological method), to verify which CR technique within each method of obtaining CR generates the greatest reproducibility of the condylar positions (or mandibular position) in CR. The PubMed, Cochrane Library, SciELO, Scopus, and Web of Science databases were searched for articles published up to May 5, 2021. The search terms were combinations of “dental centric relation” (MeSH), with each of the following terms (individually): “reproducibility of findings” (MeSH); “jaw relation record” (MeSH); “chin point”; “gothic arch”; “bimanual manipulation”; “swallowing” (MeSH); and “jig.” Inclusion criteria: clinical studies in English; individuals without temporomandibular dysfunction and with complete or almost complete dentition or complete edentulous; and comparison between CR techniques belonging to the same method of obtaining CR based on the reproducibility of condylar positions in CR. For each method of obtaining the CR, the following CR techniques were considered: guided method (chin point guidance and bimanual manipulation); graphic method (intraoral and extraoral gothic arch tracing); and physiologic method (swallowing and tongue retrusion along the palate). A total of 1692 articles were screened. After the inclusion and exclusion criteria were applied, six articles were included in this review. None of the included studies evaluated edentulous individuals. All included articles compared CR techniques of the guided method. Three articles concluded that the bimanual technique showed greater reproducibility of the condylar positions in CR than the chin point guidance technique, two articles showed equivalence between these techniques, and 1 article concluded that the chin point guidance technique showed greater reproducibility of the condylar positions in CR than the bimanual technique. Thus, in this systematic review, the bimanual technique was often superior (generated greater reproducibility of the CR) or at least equivalent to the chin point guidance technique. Therefore, for individuals with complete dentition and without temporomandibular disorders, the bimanual technique is more recommended.
Bond Strength and Microleakage of a Novel Glass Ionomer Cement Containing Silver Diamine Fluoride
Authors: Auychai Prim , Khumtrakoon Nichakorn , Jitongart Chonticha , Daomanee Punnamas , Laiteerapong Arunee 
Published: December 2021

Abstract
Objectives To investigate the shear bond strength and microleakage of glass ionomer cement (GIC) containing silver diamine fluoride (SDF).
Materials and Methods Sound human permanent premolars were divided into the following three groups: 1) GIC (Fuji IX), 2) GICSDF-S: GIC + SDF (Saforide), and 3) GICSDF-T: GIC + SDF (Topamine). Shear bond strength (n = 14/group) was measured using a universal testing machine and compared between groups (one-way ANOVA and Tukey HSD, p < 0.05). Microleakage (n = 15/group) at enamel and dentin margins was scored using a stereomicroscope (10x) and compared between groups (Chi-square, p < 0.05).
Results There were significant differences in shear bond strength between the GIC and GICSDF-S groups and between the GIC and GICSDF-T groups. The GIC group had the lowest shear bond strength among the groups; however, there was no significant difference between the GICSDF-S and GICSDF-T groups. The microleakage test results were not significantly different between groups at the enamel margin or dentin margins. Although the GIC group demonstrated a higher dye penetration score at the enamel and dentin margins, the difference was not significant.
Conclusions Within the limitations of this study, we conclude that incorporating SDF into GIC results in higher shear bond strength while not increasing microleakage at the enamel and dentin margins.
Long COVID Oral Cavity Symptoms Based on Selected Clinical Cases
Authors: Rafałowicz Barbara , Wagner Leopold , Rafałowicz Juliusz 
Published: December 2021

AbstractSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is characterized by variable clinical features, different durations, and several previously unheard-of late complications. Knowledge about this infection is constantly evolving.The aim of the study is to present selected cases of the most common symptoms of long COVID in the oral cavity.Among the 1,256 studied patients, 32% of them had discoloration, ulceration, and hemorrhagic changes on the oral mucosa, 29.69% had mycosis located on the tongue, 25.79% of patients had aphthous-like lesions on the hard palate, and in 12.5% atrophic cheilitis was observed. During the anamnesis, approximately 60% of patients reported salivary secretory disorders in the initial period of infection, which is 6.68% prolonged up to 4 months after systemic symptoms disappeared. In an extreme case, an aphthous-like lesion was located on the hard palate, which persisted for 6 months. Approximately 36% of patients did not agree to the proposed treatment. As a result, they only received recommendations on the use of oral hygiene products and received weekly check-ups. In this group of patients, most pathological changes spontaneously cleared after 3 weeks. The elderly with coexisting diseases, persons with a more severe SARS-CoV-2, and hospitalized patients had more extensive and severe lesions in the oral cavity that persisted for a long time after infection.In patients after the SARS-CoV-2 infection and suspected of this infection, a detailed intraoral examination should be performed, and the patient must be obligatorily monitored for a minimum period of 6 months. Depending on the patient's clinical condition, changes in the oral cavity require observation, basic or specialist treatment. In the case of changes in the cavity without pain symptoms, observation should be made for approximately 4 weeks and wait for the spontaneous regression of the changes. However, when pain occurs, a good solution is to use laser biostimulation. In the case of complex pathological changes occurring in the oral cavity, the patient should be directed for specialist treatment.
Laterotrusion (Side to Side) and Protrusion/Retraction Difficulty of Tongue in Two Children with Wilson's Disease
Authors: Koul Roshan , Maria Arjun , Alam Seema 
Published: December 2021

AbstractInvolvement of tongue is uncommon in Wilson's disease (WD) in early stages. This is usually seen late when the patient has an established neurological WD associated with dyskinesia, dystonia, and tremors. In this article, we presented two children with tongue involvement in which there were slow laterotrusion (side to side) and protrusion and retraction movements. In the first child this was the early and only manifestation without any other neurological features while in the second child this was seen in a previously diagnosed WD. Slow tongue movements in any child with or without extrapyramidal features should be investigated to rule out a treatable condition like WD. Tongue involvement is common in children with different neurological/neuromuscular diseases, drugs, and other unknown conditions.