bluuebunny/crossref_metadata_2025_split huggingface dataset:
The more, the better? Forecasting gains from high-frequency housing prices in a Markov-switching dynamic factor model
Authors: Huang MeiChi 
Published: August 2021

AbstractThis paper extracts housing boom-bust cycle signals from metropolitan statistical area (MSA)-level housing prices using a Markov-switching dynamic factor model. To mitigate the estimation bias, it utilizes high-frequency housing prices that follow the methodology of the monthly Case–Shiller house price indices. The housing bust phases specified from weekly and daily housing prices precede those based on monthly prices by approximately 2 years. MSAs with top signal-to-noise ratios offer greater marginal contributions to improvements in forecasting housing cycles than MSAs with bottom ratios for all frequencies. The results highlight the importance of indicator quality and provide evidence against “The more, the better” since incorporating more MSA-level housing prices into housing factors does not guarantee more satisfactory housing cycle forecasts.
Alternate History: A Synthetic Ensemble of Ocean Chlorophyll Concentrations
Authors: Elsworth Geneviève W. , Lovenduski Nicole S. , McKinnon Karen A. 
Published: August 2021

AbstractInternal climate variability plays an important role in the abundance and distribution of phytoplankton in the global ocean. Previous studies using large ensembles of Earth system models (ESMs) have demonstrated their utility in the study of marine phytoplankton variability. These ESM large ensembles simulate the evolution of multiple alternate realities, each with a different phasing of internal climate variability. However, ESMs may not accurately represent real world variability as recorded via satellite and in situ observations of ocean chlorophyll over the past few decades. Observational records of surface ocean chlorophyll equate to a single ensemble member in the large ensemble framework, and this can cloud the interpretation of long‐term trends: are they externally forced, caused by the phasing of internal variability, or both? Here, we use a novel statistical emulation technique to place the observational record of surface ocean chlorophyll into the large ensemble framework. Much like a large initial condition ensemble generated with an ESM, the resulting synthetic ensemble represents multiple possible evolutions of ocean chlorophyll concentration, each with a different sampling of internal climate variability. We further demonstrate the validity of our statistical approach by recreating an ESM ensemble of chlorophyll using only a single ESM ensemble member. We use the synthetic ensemble to explore the interpretation of long‐term trends in the presence of internal variability and find a wider range of possible trends in chlorophyll due to the sampling of internal variability in subpolar regions than in subtropical regions.
Cohesive Sediment Modeling in a Shallow Estuary: Model and Environmental Implications of Sediment Parameter Variation
Authors: Allen Rachel M. , Lacy Jessica R. , Stevens Andrew W. 
Published: August 2021

AbstractNumerical models of sediment transport in estuarine systems rely on parameter values that are often poorly constrained and can vary on timescales relevant to model processes. The selection of parameter values can affect the accuracy of model predictions, while environmental variation of these parameters can impact the temporal and spatial ranges of sediment fluxes, erosion, and deposition in the real world. We implemented a numerical model of San Pablo Bay, an embayment within San Francisco Bay, California, for November–December 2014, and compared model outputs to observations of water level, velocity, wave parameters, salinity, and suspended sediment concentration (SSC) in the shallow regions. Idealized model runs show that wind timing relative to the phase of the tides is the strongest control on sediment fluxes and bed erosion. We varied sediment erodibility in the outflow of the Petaluma River; while this causes erosion and deposition to vary strongly through the shallows system, total export from the shallows does not change. Model runs with realistic winds show that wind likely resuspends faster settling particles or allows for more particle flocculation; particle settling velocity controls system‐wide sediment accumulation. At the margins of the system, the magnitude of SSC is closely tied to wind direction when winds occur during flood tide, but sediment deposition is less connected: Both bed evolution and SSC need to be considered in the prediction of marsh fate. Spatial patterns of light attenuation due to SSC is strongly tied to assumed settling velocity.
Impact of Thermohaline Variability on Sea Level Changes in the Southern Ocean
Authors: Kolbe Marlen , Roquet Fabien , Pauthenet Etienne , Nerini David 
Published: August 2021

AbstractThe Southern Ocean is responsible for the majority of the global oceanic heat uptake that contributes to global sea level rise. At the same time, ocean temperatures do not change at the same rate in all regions and sea level variability is also affected by changes in salinity. This study investigates 10 years of steric height variability (2008–2017) in the Southern Ocean (30°S to 70°S) by analyzing temperature and salinity variations obtained from the GLORYS‐031 model provided by the European Copernicus Marine Environment Monitoring Service. The thermohaline variability is decomposed into thermohaline modes using a functional Principal Component Analysis. Thermohaline modes provide a natural basis to decompose the joint temperature‐salinity vertical profiles into a sum of vertical modes weighted by their respective principal components that can be related to steric height. Interannual steric height trends are found to differ significantly between subtropical and subpolar regions, simultaneously with a shift from a thermohaline stratification dominated by the first “thermal” mode in the north to the second ’saline’ mode in the South. The Polar Front appears as a natural boundary between the two regions, where steric height variations are minimized. Despite higher melt rates and atmospheric temperatures, steric height in Antarctic waters (0–2,000 m) has dropped since 2008 due to higher salt content in the surface and upper intermediate layer and partially colder waters, while subtropical waters farther north have mostly risen due to increased heat storage.
Double-bowl state in photonic Dirac nodal line semimetal
Authors: Hu Mengying , Zhang Ye , Jiang Xi , Qiao Tong , Wang Qiang , Zhu Shining , Xiao Meng , Liu Hui 
Published: August 2021

AbstractThe past decade has seen a proliferation of topological materials for both insulators and semimetals in electronic systems and classical waves. Topological semimetals exhibit topologically protected band degeneracies, such as nodal points and nodal lines. Dirac nodal line semimetals (DNLS), which own four-fold line degeneracy, have drawn particular attention. DNLSs have been studied in electronic systems but there is no photonic DNLS. Here in this work, we provide a new mechanism, which is unique for photonic systems to investigate a stringent photonic DNLS. When truncated, the photonic DNLS exhibits double-bowl states (DBS), which comprise two sets of perpendicularly polarized surface states. In sharp contrast to nondegenerate surface states in other photonic systems, here the two sets of surface states are almost degenerate over the whole-spectrum range. The DBS and the bulk Dirac nodal ring (DNR) dispersion along the relevant directions, are experimentally resolved.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
Authors: Xu Ying , Su Guan-Hua , Ma Ding , Xiao Yi , Shao Zhi-Ming , Jiang Yi-Zhou 
Published: August 2021

AbstractImmunotherapies play critical roles in cancer treatment. However, given that only a few patients respond to immune checkpoint blockades and other immunotherapeutic strategies, more novel technologies are needed to decipher the complicated interplay between tumor cells and the components of the tumor immune microenvironment (TIME). Tumor immunomics refers to the integrated study of the TIME using immunogenomics, immunoproteomics, immune-bioinformatics, and other multi-omics data reflecting the immune states of tumors, which has relied on the rapid development of next-generation sequencing. High-throughput genomic and transcriptomic data may be utilized for calculating the abundance of immune cells and predicting tumor antigens, referring to immunogenomics. However, as bulk sequencing represents the average characteristics of a heterogeneous cell population, it fails to distinguish distinct cell subtypes. Single-cell-based technologies enable better dissection of the TIME through precise immune cell subpopulation and spatial architecture investigations. In addition, radiomics and digital pathology-based deep learning models largely contribute to research on cancer immunity. These artificial intelligence technologies have performed well in predicting response to immunotherapy, with profound significance in cancer therapy. In this review, we briefly summarize conventional and state-of-the-art technologies in the field of immunogenomics, single-cell and artificial intelligence, and present prospects for future research.
The neurological level of spinal cord injury and cardiovascular risk factors: a systematic review and meta-analysis
Authors: Raguindin Peter Francis , Fränkl Gion , Itodo Oche Adam , Bertolo Alessandro , Zeh Ramona Maria , Capossela Simona , Minder Beatrice , Stoyanov Jivko , Stucki Gerold , Franco Oscar H. , Muka Taulant , Glisic Marija 
Published: August 2021

Abstract
Study design
Systematic review and meta-analysis.

Objective
To determine the difference in cardiovascular risk factors (blood pressure, lipid profile, and markers of glucose metabolism and inflammation) according to the neurological level of spinal cord injury (SCI).

Methods
We searched 5 electronic databases from inception until July 4, 2020. Data were extracted by two independent reviewers using a pre-defined data collection form. The pooled effect estimate was computed using random-effects models, and heterogeneity was calculated using I2 statistic and chi-squared test (CRD42020166162).

Results
We screened 4863 abstracts, of which 47 studies with 3878 participants (3280 males, 526 females, 72 sex unknown) were included in the meta-analysis. Compared to paraplegia, individuals with tetraplegia had lower systolic and diastolic blood pressure (unadjusted weighted mean difference, −14.5 mmHg, 95% CI −19.2, −9.9; −7.0 mmHg 95% CI −9.2, −4.8, respectively), lower triglycerides (−10.9 mg/dL, 95% CI −19.7, −2.1), total cholesterol (−9.9 mg/dL, 95% CI −14.5, −5.4), high-density lipoprotein (−1.7 mg/dL, 95% CI −3.3, −0.2) and low-density lipoprotein (−5.8 mg/dL, 95% CI −9.0, −2.5). Comparing individuals with high- vs. low-thoracic SCI, persons with higher injury had lower systolic and diastolic blood pressure (−10.3 mmHg, 95% CI −13.4, −7.1; −5.3 mmHg 95% CI −7.5, −3.2, respectively), while no differences were found for low-density lipoprotein, serum glucose, insulin, and inflammation markers. High heterogeneity was partially explained by age, prevalent cardiovascular diseases and medication use, body mass index, sample size, and quality of studies.

Conclusion
In SCI individuals, the level of injury may be an additional non-modifiable cardiovascular risk factor. Future well-designed longitudinal studies with sufficient follow-up and providing sex-stratified analyses should confirm our findings and explore the role of SCI level in cardiovascular health and overall prognosis and survival.
Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability
Authors: Haag Natja , Tan Ene-Choo , Begemann Matthias , Buschmann Lars , Kraft Florian , Holschbach Petra , Lai Angeline H. M. , Brett Maggie , Mochida Ganeshwaran H. , DiTroia Stephanie , Pais Lynn , Neil Jennifer E. , Al-Saffar Muna , Bastaki Laila , Walsh Christopher A. , Kurth Ingo , Knopp Cordula 
Published: August 2021

AbstractHeterozygous missense variants in the WD repeat domain 11 (WDR11) gene are associated with hypogonadotropic hypogonadism in humans. In contrast, knockout of both alleles of Wdr11 in mice results in a more severe phenotype with growth and developmental delay, features of holoprosencephaly, heart defects and reproductive disorders. Similar developmental defects known to be associated with aberrant hedgehog signaling and ciliogenesis have been found in zebrafish after Wdr11 knockdown. We here report biallelic loss-of-function variants in the WDR11 gene in six patients from three independent families with intellectual disability, microcephaly and short stature. The findings suggest that biallelic WDR11 variants in humans result in an overlapping but milder phenotype compared to Wdr11-deficient animals. However, the observed human phenotype differs significantly from dominantly inherited variants leading to hypogonadotropic hypogonadism, suggesting that recessive WDR11 variants result in a clinically distinct entity.
Bio-mimetic synthesis of catalytically active nano-silver using Bos taurus (A-2) urine
Authors: Sarvalkar Prashant D. , Mandavkar Rutuja R. , Nimbalkar Mansingraj S. , Sharma Kiran K. , Patil Pramod S. , Kamble Ganesh S. , Prasad Neeraj R. 
Published: August 2021

AbstractHerein we have synthesized silver nanoparticles (Ag NPs) using liquid metabolic waste of Bos taurus (A-2 type) urine. Various bio-molecules present in cow urine, are effectively used to reduce silver (Ag) ions into silver nanoparticles in one step. This is bio-inspired electron transfer to Ag ion for the formation of base Ag metal and is fairly prompt and facile. These nanoparticles act as a positive catalyst for various organic transformation reactions. The structural, morphological, and optical properties of the as-synthesized Ag NPs are widely characterized by X-ray diffraction spectroscopy, ultraviolet–visible spectroscopy, scanning electron microscope, Fourier transmission infra-red spectroscopy, and atomic force microscopy. The as-synthesized bio-mimetic Ag NPs show potential activity for several reduction reactions of nitro groups. The Ag NPs were also used for degradation of hazardous dyes such as Methylene blue and Crystal violet with good degradation rate constant.
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction
Authors: Estrada Armando , Rodriguez Alejandro C. , Rodriguez Georgialina , Grant Alice H. , Ayala-Marin Yoshira M. , Arrieta Amy J. , Kirken Robert A. 
Published: August 2021

AbstractT-cell activation and cellular expansion by common gamma chain cytokines such as Interleukin-2 is necessary for adaptive immunity. However, when unregulated these same pathways promote pathologies ranging from autoimmune disorders to cancer. While the functional role of Interleukin-2 and downstream effector molecules is relatively clear, the repertoire of phosphoregulatory proteins downstream of this pathway is incomplete. To identify phosphoproteins downstream of common gamma chain receptor, YT cells were radiolabeled with [32P]-orthophosphate and stimulated with Interleukin-2. Subsequently, tyrosine phosphorylated proteins were immunopurified and subjected to tandem mass spectrometry—leading to the identification of CrkL. Phosphoamino acid analysis revealed concurrent serine phosphorylation of CrkL and was later identified as S114 by mass spectrometry analysis. S114 was inducible through stimulation with Interleukin-2 or T-cell receptor stimulation. Polyclonal antibodies were generated against CrkL phospho-S114, and used to show its inducibility by multiple stimuli. These findings confirm CrkL as an Interleukin-2 responsive protein that becomes phosphorylated at S114 by a kinase/s downstream of PI3K and MEK/ERK signaling.
Glacial mode shift of the Atlantic meridional overturning circulation by warming over the Southern Ocean
Authors: Oka Akira , Abe-Ouchi Ayako , Sherriff-Tadano Sam , Yokoyama Yusuke , Kawamura Kenji , Hasumi Hiroyasu 
Published: August 2021

AbstractAbrupt climate warming events, known as Dansgaard-Oeschger events, occurred frequently during glacial periods, and are thought to be linked to changes in the Atlantic meridional overturning circulation. However, the mechanism responsible is not fully understood. Here, we present numerical simulations with a sea-ice coupled ocean general circulation model that systematically investigate the thermal threshold where deep water formation, and hence the overturning circulation, shift abruptly when the sea surface cools or warms sufficiently. Specifically, in our simulations where the magnitude of the sea surface cooling is changed separately or simultaneously in the Northern and Southern Hemispheres, a prominent threshold is identified when the Southern Hemisphere is slightly warmer than during glacial maxima. Abrupt mode changes of the Atlantic Meridional Overturning Circulation, like those during Dansgaard-Oeschger events, occur past a threshold in a transient simulation where the Southern Hemisphere is gradually warmed. We propose that the Southern Ocean plays a role in controlling the thermal threshold of the Atlantic Meridional Overturning Circulation in a glacial climate and that Southern Ocean warming may have triggered Dansgaard-Oeschger events which occurred with long interval.
The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework
Authors: Massimino Luca , Lamparelli Luigi Antonio , Houshyar Yashar , D’Alessio Silvia , Peyrin-Biroulet Laurent , Vetrano Stefania , Danese Silvio , Ungaro Federica 
Published: August 2021

AbstractInflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis is still unknown. Despite the high number of IBD-related omics studies, the RNA-sequencing data produced results that are hard to compare because of the experimental variability and different data analysis approaches. We here introduce the IBD Transcriptome and Metatranscriptome Meta-Analysis (TaMMA) framework, a comprehensive survey of publicly available IBD RNA-sequencing datasets. IBD TaMMA is an open-source platform where scientists can explore simultaneously the freely available IBD-associated transcriptomics and microbial profiles thanks to its interactive interface, resulting in a useful tool to the IBD community.
Distinct effects of host and neighbour tree identity on arbuscular and ectomycorrhizal fungi along a tree diversity gradient
Authors: Ferlian Olga , Goldmann Kezia , Eisenhauer Nico , Tarkka Mika T , Buscot François , Heintz-Buschart Anna 
Published: August 2021

Abstract
Plant diversity and plant-related ecosystem functions have been important in biodiversity-ecosystem functioning studies. However, biotic interactions with mycorrhizal fungi have been understudied although they are crucial for plant-resource acquisition. Here, we investigated the effects of tree species richness and tree mycorrhizal type on arbuscular (AMF) and ectomycorrhizal fungal (EMF) communities. We aimed to understand how dissimilarities in taxa composition and beta-diversity are related to target trees and neighbours of the same or different mycorrhizal type. We sampled a tree diversity experiment with saplings (~7 years old), where tree species richness (monocultures, 2-species, and 4-species mixtures) and mycorrhizal type were manipulated. AMF and EMF richness significantly increased with increasing tree species richness. AMF richness of mixture plots resembled that of the sum of the respective monocultures, whereas EMF richness of mixture plots was lower compared to the sum of the respective monocultures. Specialisation scores revealed significantly more specialised AMF than EMF suggesting that, in contrast to previous studies, AMF were more specialised, whereas EMF were not. We further found that AMF communities were little driven by the surrounding trees, whereas EMF communities were. Our study revealed drivers of mycorrhizal fungal communities and further highlights the distinct strategies of AMF and EMF.
Wirksamkeit und Sicherheit von Home-Treatment in der Kinder- und Jugendpsychiatrie: Eine systematische Literaturübersicht
Authors: Zechmeister-Koss Ingrid , Grössmann Nicole , Wolf Sarah 
Published: August 2021

Zusammenfassung
Ziel der Studie In der Kinder- und Jugendpsychiatrie gewinnt aufgrund limitierter stationärer Versorgungskapazitäten sowie sich verändernden Behandlungsphilosophien das Home-Treatment an Bedeutung. Die Arbeit untersucht dessen Wirksamkeit und Sicherheit.
Methodik Es wurde eine systematische Literaturrecherche durchgeführt und die Home-Treatment-Modelleigenschaften sowie die Evidenz zu Nutzen und Risiken im Vergleich zu institutionellen Behandlungsalternativen narrativ zusammengefasst.
Ergebnisse In den 6 identifizierten Studien wurden sowohl beim Home-Treatment als auch bei stationär Behandelten Symptomverbesserungen festgestellt. Langfristig scheint das Home-Treatment etwas überlegen und mit weniger Krankenhaustagen verbunden zu sein. Ein Best-practice-Modell kann nicht abgeleitet werden.
Schlussfolgerungen Home-Treatment kann als Alternative zu stationärer Behandlung in Betracht gezogen werden, erfordert jedoch Koordinierung mit anderen Versorgungselementen und weitere Evaluation.
Cerebrospinal Fluid Leak after Transsphenoidal Surgery: A Systematic Review and Meta-analysis
Authors: Slot Emma M.H. , Sabaoglu Rengin , Voormolen Eduard H.J. , Hoving Eelco W. , van Doormaal Tristan P.C. 
Published: August 2021

Abstract
Background Cerebrospinal fluid (CSF) leak is widely recognized as a challenging and commonly occurring postoperative complication of transsphenoidal surgery (TSS).The primary objective of this study is to benchmark the current prevalence of CSF leak after TSS in the adult population.
Methods The authors followed the PRISMA guidelines. The PubMed, Embase, and Cochrane Library databases were searched for articles reporting CSF leak after TSS in the adult population. Meta-analysis was performed using the Untransformed Proportion metric in OpenMetaAnalyst. For two between-group comparisons a generalized linear mixed model was applied.
Results We identified 2,408 articles through the database search, of which 70, published since 2015, were included in this systematic review. These studies yielded 24,979 patients who underwent a total of 25,034 transsphenoidal surgeries. The overall prevalence of postoperative CSF leak was 3.4% (95% confidence interval or CI 2.8–4.0%). The prevalence of CSF leak found in patients undergoing pituitary adenoma resection was 3.2% (95% CI 2.5–4.2%), whereas patients who underwent TSS for another indication had a CSF leak prevalence rate of 7.1% (95% CI 3.0–15.7%) (odds ratio [OR] 2.3, 95% CI 0.9–5.7). Patients with cavernous sinus invasion (OR 3.0, 95% CI 1.1–8.7) and intraoperative CSF leak (OR 5.9, 95% CI 3.8–9.0) have increased risk of postoperative CSF leak. Previous TSS and microscopic surgery are not significantly associated with postoperative CSF leak.
Conclusion The overall recent prevalence of CSF leak after TSS in adults is 3.4%. Intraoperative CSF leak and cavernous sinus invasion appear to be significant risk factors for postoperative CSF leak.