bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential anti-tumor immune response mechanisms of SARS-CoV-2 in lymphomas: can the devil be converted into a boon?
Authors: Barh Debmalya , Tiwari Sandeep , Gomes Lucas Gabriel Rodrigues , Weener Marianna E. , Alzahrani Khalid J. , Alsharif Khalaf F. , Aljabali Alaa A. A. , Tambuwala Murtaza M. , Lundstrom Kenneth , Hassan Sk. Sarif , Serrano-Aroca Ángel , Takayama Kazuo , Ghosh Preetam , Redwan Elrashdy M. , Andrade Bruno Silva , Soares Siomar de Castro , Azevedo Vasco , Uversky Vladimir N. 
Published: August 2021

Abstract
Recently, two cases of complete remission of classical Hodgkin lymphoma (cHL) and follicular lymphoma (FL) after SARS-CoV-2 infection were reported. However, the precise molecular mechanism of this rare event is yet to be understood. Here, we hypothesize a potential anti-tumor immune response of SARS-CoV-2 and based on computational approach show that (i) SARS-CoV-2 Spike-RBD may bind to extracellular domains of CD15, CD27, CD45, and CD152 receptors of cHL or FL, (ii) upon internalization, SARS-CoV-2 membrane (M) protein and Orf3a may bind to gamma-tubulin complex component 3 (GCP3) at its tubulin gamma-1 chain (TUBG1) binding site, (iii) M protein may also interact with TUBG1 blocking its binding to GCP3, (iv) both M and Orf3a may render the GCP2-GCP3 lateral binding where M possibly interacts with GCP2 at its GCP3 binding site and Orf3a to GCP3 at its GCP2 interacting residues, (v) interactions of M and Orf3a with these gamma-tubulin ring complex components potentially block the initial process of microtubule nucleation, leading to cell cycle arrest and apoptosis, (vi) Spike-RBD may also interact with and block PD-1 signaling similar to pembrolizumab and nivolumab like monoclonal antibodies and may induce B-cell apoptosis and remission, (vii) finally, the TRADD interacting PVQLSY motif of Epstein-Barr virus LMP-1, that is responsible for NF-kB mediated oncogenesis, potentially interacts with SARS-CoV-2 Mpro, nsp7, nsp10, and Spike proteins and may regulate the LMP-1 mediated cell proliferation. Taken together, our results suggest a possible therapeutic potential of SARS-CoV-2 in proliferative disorders.
Does De-Implementation of Low Value Care Impact the Patient-Clinician Relationship? A Mixed Methods Study
Authors: Rockwell Michelle S. , Michaels Kenan C. , Epling John W. 
Published: August 2021

Abstract
Background: The importance of reducing low-value care (LVC) is increasingly recognized, but the impact of de-implementation on the patient-clinician relationship is not well understood. This mixed-methods study explored the impact of LVC de-implementation on the patient-clinician relationship. Methods: Adult primary care patients from a large Virginia health system volunteered to participate in a survey (n=232) or interview (n=24). Participants completed the Patient-Doctor Relationship Questionnaire (PDRQ-9) after reading a vignette about a clinician declining to provide a low-value service: antibiotics for acute sinusitis (LVC-antibiotics); screening EKG (LVC-EKG); screening vitamin D test (LVC-vitamin D); or a comparison vignette about a high-value service, and imagining that their own primary care clinician had acted in the same manner. A different sample of participants was asked to imagine that their own primary care clinician did not order LVC-antibiotics or LVC-EKG and then respond to semi-structured interview questions. Outcomes data included participant demographics, PDRQ-9 scores (higher score = greater relationship integrity), and content analysis of transcribed interviews. Differences in PDRQ-9 scores were analyzed using one-way ANOVA. Data were integrated for analysis and interpretation. Results: Although participants generally agreed with the vignette narrative (not providing LVC), many demonstrated difficulty comprehending the broad concept of LVC and potential harms. The topic triggered memories of negative experiences with healthcare (typically poor-quality care, not necessarily LVC). The most common recommendation for reducing LVC was for patients to take greater responsibility for their own health. Most participants believed that their relationship with their clinician would not be negatively impacted by not receiving the described service because they trusted their clinician’s guidance. Participants emphasized that trusted clinicians are those who listen to them, spend time with them, and offer understandable advice. Some felt that not providing LVC would actually increase their trust in their clinician. Similar PDRQ-9 scores were observed for LVC-antibiotics (38.9), LVC-EKG (37.5), and the comparison vignette (36.4), but LVC-vitamin D was associated with a significantly lower score (31.2) (p<0.05). Conclusions: Findings suggest minimal impact of LVC de-implementation on the patient-clinician relationship, although service-specific differences may exist. Further research on enhancing patient trust through LVC de-implementation is needed.
ENO1 Inhibits Apoptosis and Promotes Cell Invasion and Proliferation in Malignant Melanoma
Authors: Zhang Kun , Tian Ruoxi , Zhang Wancong , Li Yishuai , Zeng Ning , Liang Yan , Tang Shijie 
Published: August 2021

Abstract
Introduction

The glycolytic enzyme, α-Enolase (ENO1), catalyzes the production of phosphoenolpyruvate from 2-phosphoglycerate, which enhances glycolysis, and thus contributes to tumor progression. In the present study, we aimed to determine ENO1’s role in malignant melanoma (MM) and the potential underlying mechanism.
Methods

Western blotting was used to assess the levels of ENO1, c-Myc, β-catenin, MMP-9, PGAM1, and MMP-13 in MM-derived cell lines or tumor tissues from patients with MM. Plasmids pCMV-SPORT6-ENO1 and pET-28a-ENO1siRNA plasmids were used to overexpress and knockdown ENO1 in MM cells, respectively. To determine the function of ENO1 in the malignant behavior of MM cells, we performed wound healing, Cell counting kit 8, Transwell chamber, and flow cytometry analyses. Pyruvate determination and lactic acid kits were used to evaluate the production of pyruvate and lactic acid in tumor cells.
Results

The protein levels of ENO1 and PGAM1 in MM tissue were significantly higher than that in mole tissue. In MM cells, ENO1 overexpression inhibited apoptosis; promoted invasion, migration, and proliferation; increased pyruvate and lactate production; and increased in β-catenin, MMP-9, MMP-13, and c-Myc levels. The opposite effects were observed in MM cells silenced for ENO1.
Conclusion

These results indicated that ENO1 is involved in MM progression by enhancing invasion and proliferation, while inhibiting apoptosis. In addition, ENO1 might have an important function in tumor cell glycolysis. Therefore, ENO1 represents a potential therapeutic target to treat MM.
Peacekeeping: The Role of Police in Peshawar Pakistan from 2013-2018
Authors: Ullah Shafi , Hussain Altaf 
Published: August 2021

Abstract
Peacekeeping role is an important factor for the society and the people what lives under it accordingly. It has been there for centuries this think and phenomena to persuade people for their desire and their duty to be fully utilized. This is the active maintenance of a truce between nations or communities, especially by an international military force but in this perspective the military force are considered the POLICE. Peacekeeping comprises activities intended to create conditions that favour lasting peace. Research generally finds that peacekeeping reduces civilian and battlefield deaths and reduces the risk of renewed warfare. There are a range of various types of operations encompassed in peacekeeping such as Observation Missions, Interpositional Missions, Multidimensional missions and Peace enforcement Missions. Even though within the United Nations (UN) group of nation-state governments and organizations, there is a general understanding that at the international level, peacekeepers monitor and observe peace processes in post-conflict areas, and may assist ex-combatants in implementing peace agreement commitments that they have undertaken. In this research, the role of peacekeeping in Peshawar has been conducted as year wise from 2013–2018. This shows about five years gape and also reveals that how much changes have been done since then and now. Challenges and difficulties have been analyzed that Police have face in last 5 years. The role of peacekeeping has been examined in last 5 years and then these are evaluated with the contrast of the existing situations. From this study different types of results have been generated and portrayed in tables and graphs. For the purpose of investigating good work and the evaluation of peacekeeping perspectives and related methodologies have been conducted in which the important and key factors have shown that have a huge impact on peacekeeping role in society building.
Strengthening Indonesia's Economic Growth with Islamic and non-Islamic Macroeconomic Variable
Authors: Alifah Eba Ismi , Bawono Anton 
Published: August 2021

Abstract: This research was conducted to determine the effect of taxes, Sukuk, grants, inflation, foreign debt, total financing, and the network of Islamic bank offices on Indonesia's economic growth. Research data for each variable is monthly from 2009-2018. Data analysis variables use Error Correction Model (ECM) Test and Autoregressive Conditional Heteroscedasticity (ARCH) Test with Eviews ver.10. The results showed that in the short and long term, variables taxes, Sukuk, inflation, foreign debt, total financing, and office networks of Islamic banks) affected the Indonesian economic growth. At the same time, grants have no significant effect on economic growth. For variable predictions in the next year (2019), only economic growth, grants, inflation, foreign debt, and network of Islamic bank offices can be predicted. Meanwhile, taxes, Sukuk, and total financing cannot be identified in 2019 because the variables are not significant in the ARCH analysis, so it cannot be diagnosed about future values. This result implies that the government and the community must continue to work together to manage state revenues used to fund productive projects to stimulate economic growth.Abstrak: Penelitian ini dilakukan untuk mengetahui pengaruh pajak, sukuk negara, hibah, inflasi, utang luar negeri, jumlah pembiayaan dan jaringan kantor bank syariah terhadap pertumbuhan ekonomi Indonesia. Data penelitian setiap variabel berupa bulanan dari tahun 2009-2018. Uji variabel penelitian menggunakan Uji Error Correction Model (ECM) dan Uji ARCH menggunakan Eviews ver.10. Hasil penelitian menunjukkan bahwa dalam jangka pendek maupun jangka panjang, variabel pajak, sukuk negara, inflasi, utang luar negeri, jumlah pembiayaan dan jaringan kantor bank syariah berpengaruh signifikan terhadap pertumbuhan ekonomi Indonesia. Sedangkan variabel hibah tidak berpengaruh secara signifikan terhadap pertumbuhan ekonomi. Untuk prediksi variabel di tahun berikutnya (tahun 2019), hanya variabel pertumbuhan ekonomi, hibah, inflasi, utang luar negeri dan jumlah jaringan kantor bank syariah yang dapat diprediksi, sedangkan pajak, sukuk negara, dan jumlah pembiayaan tidak dapat diketahui nilai perkembangannya di tahun 2019 karena variabel tersebut tidak signifikan pada analisis ARCH. Sehingga tidak dapat di diagnosa dalam bentuk ARCH untuk dilakukan forecast data agar diketahui tentang nilai di masa yang akan datang. Implikasi dari temuan ini adalah diperlukan upaya yang berkesinambungan dari pemerintah dan masyarakat dalam mengelola penerimaan negara yang dimanfaatkan untuk mendanai proyek yang produktif sehingga dapat mempercepat pertumbuhan ekonomi.
Community-Based Halal Tourism Village: Insight from Setanggor Village
Authors: Adinugraha Hendri Hermawan , Nasarruddin Razie Bin , Rofiq Ahmad , Ulama’i Ahmad Hasan Asy’ari , Mujaddid Ade Yusuf , Sartika Mila 
Published: August 2021

Abstract: This research aims to describe the development model of Setanggor halal tourism village. This research uses qualitative research methods with a descriptive approach. The results showed that halal tourism in Setanggor village was developed through active community participation with the village government through a tourism village model based on community and halal values. The development of halal tourism villages in Setanggor is not able to be separated from religious values. As a result, Community-Based Halal Tourism in Setanggor village combines community-based tourism and halal-based tourism that will eventually serve as a model for community-based halal tourism. The growth of the halal tourism sector in Setanggor village has also provided positive benefits for enhancing the local community's well-being. In addition to the community's active role, the legality of the Setanggor halal tourism village is also supported by the local government of NTB and the Indonesian Council of Ulama.Abstrak: Penelitian ini bertujuan untuk mendeskripsikan model pengembangan desa wisata halal Setanggor. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif. Hasil penelitian menunjukkan bahwa wisata halal di Desa Setanggor dikembangkan melalui partisipasi aktif masyarakat dengan pemerintah desa melalui model “Desa Wisata Halal Berbasis Masyarakat”. Pengembangan desa wisata halal di Setanggor tidak lepas dari nilai-nilai religi. Oleh karena itu, CBT di desa Setanggor yang merupakan gabungan antara pariwisata berbasis komunitas dengan pariwisata berbasis halal pada akhirnya menjadi role model bagi wisata halal berbasis komunitas. Pertumbuhan sektor wisata halal di desa Setanggor juga memberikan manfaat positif bagi peningkatan kesejahteraan masyarakat setempat. Selain peran aktif masyarakat, legalitas desa wisata halal Setanggor juga didukung oleh pemerintah daerah NTB dan Majelis Ulama Indonesia.
Activated carbon incorporation on forward osmosis membrane surface for enhanced performance
Authors: Lakra Reshma , Balakrishnan Malini , Basu Subhankar 
Published: August 2021

AbstractCellulose triacetate (CTA) is the first-generation forward osmosis (FO) membrane used for desalination. There have been a few chemical modifications of the CTA membrane surface. This has improved membrane hydrophilicity, water flux, and salt rejection compared with unmodified CTA membranes. Chitosan-containing porous materials as composites have resulted in increased pore characteristics. It has motivated the modification of the surface of the commercial CTA forward osmosis (FO) membrane by surface coating with chitosan (CS)–powdered activated carbon (AC) mix. The membrane morphology was characterized by SEM, FTIR-ATR, contact angle measurement and AFM. Operational conditions for FO such as the orientation of the membrane active layer, feed and draw solution flow rates, and type and concentration of draw salt were optimized with the original CTA membrane. The modified membrane exhibited around a two-fold increase in the water flux and reduced reverse salt flux compared with the original CTA membrane. The improved water flux was attributed to the CS-AC coating enhancing water wettability of the membrane surface and the porous AC generating additional water flow channels. Overall, the water flux of the CTA-CS-AC membrane developed in this work was superior to that of CTA and cellulose acetate (CA) membranes reported in the literature.
PENERAPAN METODE DRILL UNTUK MENINGKATKAN KETERAMPILAN PASSING ATAS BOLA VOLI SISWA SMPN 4 TAPUNG HILIR
Authors: Khotimah Nurul 
Published: August 2021

Tujuan penelitian ini yaitu untuk meningkatkan keterampilan passing atas bolavoli melalui metode drill pada siswa kelas VIII A SMPN 4 Tapung Hilir. Jenis penelitian yang ditetapkan dalam penelitian ini adalah penelitian tindakan kelas (PTK). Ada empat tahapan dalam penelitian tindakan, yaitu (1) perencanaan, (2) pelaksanaan, (3) pengamatan, dan (4) refleksi, sedangkan penelitian ini terdiri dari dua siklus dengan masing-masing siklus terdiri dari dua kali pertemuan. Subjek penelitian dalam penelitian tindakan kelas ini adalah siswa kelas VIII A SMP N 4 Tapung Hilir dengan jumlah siswa yang diteliti sebanyak 20 siswa yang terdiri dari 10 siswa dan 10 siswi. Kesimpulan dalam penelitian ini adalah metode drill dapat meningkatkan kemampuan passing atas siswa kelas VIII A di SMPN 4 Tapung Hilir. Terjadi peningkatan kemampuan passing atas siswa dari siklus I dan siklus II. Hasil evaluasi sikus I dari 20 siswa yang berhasil mencapai KKM yaitu sebanyak 8 siswa (40%), dan hasil evaluasi nilai siklus II dari 20 siswa yang berhasil mencapai KKM yaitu sebanyak 16 siswa (80%).
MENINGKATKAN KETERAMPILAN MENULIS KARANGAN MELALUI METODE FIELD TRIP SISWA SMPN 4 TAPUNG HILIR
Authors: Jaswandi Jaswandi 
Published: August 2021

Tujuan penelitian ini yaitu untuk meningkatkan keterampilan menulis karangan melalui metode field trip kelas IX A di SMPN 4 Tapung Hilir. Jenis penelitian yang ditetapkan dalam penelitianini adalah penelitian tindakan kelas (PTK). Ada empat tahapan dalam penelitian tindakan, yaitu (1) perencanaan, (2) pelaksanaan, (3) pengamatan, dan (4) refleksi, sedangkan penelitian ini terdiri dari dua siklus dengan masing-masing siklus terdiri dari dua kali pertemuan. Subjek penelitian dalam penelitian tindakan kelas ini adalah siswa kelas IX A SMP N 4 Tapung Hilir dengan jumlah siswa yang diteliti sebanyak 31 siswa yang terdiri dari 13 siswa dan 18 siswi. Kesimpulan dalam penelitian ini adalah metode field trip dapat meningkatkan keterampilan menulis karangan atas siswa kelas IX A di SMPN 4 Tapung Hilir. Terjadi peningkatan keterampilan menulis karangan atas siswa dari siklus I dan siklus II. Hasil evaluasi sikus I dari 31 siswa yang berhasil mencapai KKM yaitu sebanyak 12 siswa (38,71%), dan hasil evaluasi nilai siklus II dari 31 siswa yang berhasil mencapai KKM yaitu sebanyak 26 siswa (83,87%).
A COMPARATIVE STUDY OF USING CLASSWIDE PEER TUTORING TECHNIQUE AND ‎STUDENT TEAM ‎ ACHIEVEMENT DEVISION TECHNIQUE IN ‎ TEACHING READING COMPREHENSION AT STATE SENIOR HIGH SCHOOL ‎ ‎1 TUALANG‎
Authors: Erika Sumita 
Published: August 2021

The purpose of this study was to explore which strategy that required a teacher for a better learning process in improving students’ reading comprehension in the eleventh grade at state senior high school Tualang. It was done based on experimental design which focused on the quantitative research group. A group were taken as experimental groups and a group as the comparison group. The sample consisted of 60 students that were taken from the eleventh grade at state senir high school Tualang which were comprised of 30 students from XI-4class for this experimental group 1 (Classwide Peer Tutoring Technique), 30 students from XI-5 class for this experimental group 2 (Student Team Achievement Technique).Observation sheets and reading comprehension tests were used in the study. There are 40 items of multiple choice questions used for the pre-test and post-test. To analyze the data, independent sample t-test were calculated by using SPSS 20 with a significant probability of Ho was accepted if P<0.05 or there was no significant effect after giving the treatments, Ha was accepted if P>0.05 or there was no significant effect after giving the treatments. Classwide Peer Tutoring Technique got the effect size or eta-squared as follows: Eta-squared = 0.84x 100% = 84%. Student Team Achievement Technique got the effect size or eta-squared as follows: Eta-squared = 0.91 x 100% = 91%. The highest effect was from Student Team Achievement Technique, but the two classes did not differ significantly. Therefore, the two strategies could improve the students’ reading comprehension.
INVESTIGATING PRAGMATICS OF APOLOGY STRATEGY: A CASE STUDY OF THE SIXTH SEMESTER ENGLISH EDUCATION STUDENTS AT INSTITUT PENDIDIKAN TAPANULI SELATAN PADANGSIDIMPUAN
Authors: Siregar Rafika Sa'adah 
Published: August 2021

This descriptive research was carried out aimed to find out the kinds of apology strategies used by English Education Students at IPTS Padangsidimpuan and the reasons for using it. This research is a single case study, namely descriptive qualitative research which means that qualitative research has described quality. Data were taken from DCT (Discourse Completion Test) and interview. The test covers situations about violations in daily life. The research participants are sixth semester English Education Students at IPTS (Institut Pendidikan Tapanuli Selatan) who have graduated in Pragmatics course. They consist of 2 classes; A and B, and by using purposive sampling technique, as many as 10 students were selected to become participants. From the results of data analysis, as many as 10 situations given to participants, there are there are 5 known strategies used by students namely; Promise patience, indirect apology / acknowledgment of responsibility, offer of improvement, explanation or account and direct apology / expression of apology with various sub categories. and for each other's reasons. Of the strategies used by students, the strategy most often used is indirect apology / recognition of responsibility four times in situations 2, 4, 5, and 6. Keywords: Pragmatics, Speech Act, Apologies, Apology Strategies.
THE INFLUENCE OF STUDENTS’ UNDERSTANDING OF SENTENCE PATTERN AND VOCABULARY MASTERY ON THEIR READING COMPREHENSION AT THE FIRST YEAR OF STATE VOCATIONAL SENIOR HIGH SCHOOL 1 LOGAS TANAH DARAT KUANTAN SINGINGI REGENCY
Authors: Sepri Sepri 
Published: August 2021

The main purpose of this research is to find out the influence of students’ understanding of sentence pattern and vocabulary mastery on their reading comprehension of recount text at State Vocational Senior High Schoo 1 Logas Tanah Darat Kuantan Singingi Regency. This is a correlational research that consists of three variables; two independent variables, namely the students’understanding of sentence pattern and their vocabulary mastery, and one dependent variable which is the students’ reading comprehension of recount text. The research participants consisted of 175 tenth-grade students at the State Vocational Senior High School. The instruments that were used to collect the data are tests. After analysing the collected data by using SPSS, the results showed that the students’ understanding of sentence pattern is at the high level (M = 73.30, SD = 1.59) and their vocabulary mastery is also at the high level (M = 70.97, SD = 1.56). Besides, their reading comprehension of recount text is at the high level too (M = 67.91, SD = 1.66). After analysing the data by using multiple regressions, the finding indicated that there is a significant influence of the students’ understanding of sentence pattern and vocabulary mastery on their reading comprehension of recount text, in which F = 82.14, p=0.000<0.05. Then the percentage of the students’ understanding of sentence pattern and vocabulary mastery is 0.842 (84.20%). Therefore, the alternative hypothesis is accepted and the null hypothesis is rejected. Keywords: Influence, Sentence Pattern, Vocabulary Mastery, Reading Comprehension