bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of aspiration versus combined technique as first-line approach in terminal internal carotid artery occlusion: a multicenter experience
Authors: Diana Francesco , Vinci Sergio Lucio , Ruggiero Maria , Semeraro Vittorio , Bracco Sandra , Frauenfelder Giulia , Paolucci Aldo , Cirillo Luigi , Pesce Alessandro , Tessitore Agostino , Commodaro Christian , Ganimede Maria Porzia , Zanoni Matteo , Saponiero Renato , Zini Andrea , Velo Mariano , Modello Beatrice , Burdi Nicola , Cioni Samuele , Simonetti Luigi , Romano Daniele Giuseppe 
Published: August 2021

BackgroundThere is no consensus on the most effective endovascular technique to use in patients with acute ischemic stroke due to terminal internal carotid artery (ICA) occlusion. The aim of this study was to compare safety and efficacy of the aspiration technique (AT) and combined technique (CT) as first-line approach in terminal ICA occlusions.MethodsWe performed a retrospective analysis of prospectively collected databases from seven Italian stroke centers. Patients were divided into two subgroups according to the first-line approach: AT group or CT group. We followed the STROBE guidelines for cohort studies. We used Chi-square test, one-way and multivariate ANOVA analysis, together with contrast analysis and post hoc tests, logistic regression and Pearson’s bivariate correlation for the statistical analyses.ResultsBetween January 2018 and August 2020, 353 patients were treated for a terminal ICA occlusion, with either AT or CT. CT was associated with a higher Thrombolysis in Cerebral Infarction (TICI) 2B-3 after the first pass (51.0% vs 26.9%) and at the end of the procedure (84% vs 73.3%) and with an improved clinical outcome at discharge (modified Rankin Scale (mRs) 0–2 of 47.8% vs 34.0%) and at 3 months’ follow-up (mRs 0–2 of 56.5% vs 38.9%) compared with AT.ConclusionThrombectomy of terminal ICA occlusions obtained using CT as first-line approach demonstrated better technical and functional outcomes in comparison with AT.
Safety and efficacy of balloon-mounted stent in the treatment of symptomatic intracranial atherosclerotic disease: a multicenter experience
Authors: Mohammaden Mahmoud H , Nogueira Raul G , Tekle Wondwossen , Ortega-Gutierrez Santiago , Farooqui Mudassir , Zevallos Cynthia B. , Hanel Ricardo A , Cortez Gustavo M , Aghaebrahim Amin , Starke Robert M , Aref Hany , Elbassiouny Ahmed , Gamea Ayman , Alaraj Ali , Sadeh Morteza , Grigoryan Mikayel , Kuybu Okkes , Haussen Diogo C , Sheth Sunil A , Maud Alberto , Cordina Steve M , Tanweer Omar , Kan Peter , Burkhardt Jan-Karl , Grandhi Ramesh , Siddiq Farhan , Hassan Ameer E 
Published: August 2021

BackgroundRandomized clinical trials have failed to prove that the safety and efficacy of endovascular treatment for symptomatic intracranial atherosclerotic disease (ICAD) is better than that of medical management. A recent study using a self-expandable stent showed acceptable lower rates of periprocedural complications.ObjectiveTo study the safety and efficacy of a balloon-mounted stent (BMS) in the treatment of symptomatic ICAD.MethodsProspectively maintained databases from 15 neuroendovascular centers between 2010 and 2020 were reviewed. Patients were included if they had severe symptomatic intracranial stenosis in the target artery, medical management had failed, and they underwent intracranial stenting with BMS after 24 hours of the qualifying event. The primary outcome was the occurrence of stroke and mortality within 72 hours after the procedure. Secondary outcomes were the occurrence of stroke, transient ischemic attacks (TIAs), and mortality on long-term follow-up.ResultsA total of 232 patients were eligible for the analysis (mean age 62.8 years, 34.1% female). The intracranial stenotic lesions were located in the anterior circulation in 135 (58.2%) cases. Recurrent stroke was the qualifying event in 165 (71.1%) while recurrent TIA was identified in 67 (28.9%) cases. The median (IQR) time from the qualifying event to stenting was 5 (2–20.75) days. Strokes were reported in 13 (5.6%) patients within 72 hours of the procedure; 9 (3.9%) ischemic and 4 (1.7%) hemorrhagic, and mortality in 2 (0.9%) cases. Among 189 patients with median follow-up time 6 (3–14.5) months, 12 (6.3%) had TIA and 7 (3.7%) had strokes. Three patients (1.6%) died from causes not related to stroke.ConclusionOur study has shown that BMS may be a safe and effective treatment for medically refractory symptomatic ICAD. Additional prospective randomized clinical trials are warranted.
Direct endovascular treatment versus bridging therapy in patients with acute ischemic stroke eligible for intravenous thrombolysis: systematic review and meta-analysis
Authors: Zhang Jian , Chen Shijian , Shi Shengliang , Zhang Yueling , Kong Deyan , Xie Yiju , Deng Xuhui , Tang Jian , Luo Jinglian , Liang Zhijian 
Published: August 2021

ObjectiveIn this review and meta-analysis we sought to compare the efficacy and safety of direct endovascular thrombectomy (EVT) and bridging therapy for intravenous thrombolysis (IVT)-eligible patients with acute ischemic stroke caused by large vessel occlusions (AIS-LVO).MethodsWe searched Medline, Embase, and the Cochrane Library for published randomized clinical trials (RCTs) and observational studies providing outcomes of patients with IVT-eligible AIS-LVO who have undergone EVT with or without IVT. The primary outcome was the proportion of patients achieving a modified Rankin Scale (mRS) score of 0–2 at 90 days. The secondary outcomes included the rates of (1) an excellent outcome defined as an mRS score of 0 or 1 at 90 days, (2) mortality at 90 days, (3) symptomatic intracranial hemorrhage (sICH), (4) any type of intracranial hemorrhage (ICH), (5) successful recanalization, and (6) clot migration.ResultsWe included three RCTs and six observational studies (4 of which were propensity score-adjusted studies) with a total of 3133 patients. In unadjusted and adjusted analyses, no differences in the rates of mRS scores 0–2, mRS scores 0–1, mortality at 90 days, sICH or successful recanalization were detected between patients with AIS-LVO who underwent direct EVT or bridging therapy. The patients treated with direct EVT had a lower risk ratio for any type of ICH and clot migration than did the patients treated with bridging therapy.ConclusionCompared with bridging therapy, direct EVT may be equally effective and yield a lower rate of ICH and clot migration in patients with AIS.Trail registration numberPROSPERO: CRD42021236691.
Internationally validated score to predict the outcome of non-paroxysmal atrial fibrillation ablation: the ‘FLAME score’
Authors: Boyalla Vennela , Jarman Julian W E , Markides Vias , Hussain Wajid , Wong Tom , Mead R Hardwin , Engel Gregory , Kong Melissa H , Patrawala Rob A , Winkle Roger A 
Published: August 2021

BackgroundThe clinical effectiveness of ablating non-paroxysmal atrial fibrillation (non-PAF) relies on proper patient selection. We developed and validated a scoring system to predict non-PAF ablation outcomes.MethodsData on 416 non-PAF ablations were analysed using binary logistic regression at a London centre. Identified preprocedural variables, which independently predicted freedom from atrial tachyarrhythmia. Twenty-one possible predictive variables and a model with c-statistic 0.751—explained outcome variation in London at mean follow-up 12±3 months. An additive point score (range 0–9) was developed—the FLAME score: female=1; long-lasting persistent atrial fibrillation=1; left atrial diameter in mm: 40 to <45 = 1, 45 to <50 = 2, 50 to <55=3, ≥55 =4; mitral regurgitation (MR) mild to moderate=1; extreme comorbidity=2. Extreme comorbidities include severe MR, moderate mitral stenosis, mitral replacement, hypertrophic cardiomyopathy or congenital heart disease.ResultsThe FLAME score was applied to data (882 non-PAF ablations) at a Californian centre, and predicted the outcome of both single (p<0.0001) and multiple (p<0.0001) procedures. For first ablation (follow-up 2.1 years (median, IQR 1.0–4.1)), FLAME score: 0–1 predicts 62% success, 2–4 44% and ≥5 29% (Ptrend<0.0001). After the final ablation (mean procedures: 1.4±0.6, follow-up 1.8 years (median, IQR 0.8–3.6)), FLAME score: 0–1 predicts 81% success, 2–4 65% and ≥5 44% (Ptrend<0.0001).ConclusionsFLAME score is easily calculated, derived in London, and predicted single and multiple procedural outcomes for non-PAF ablations in California. In patients with a high score, even multiple procedures are usually ineffective.
Eastern white pine and eastern hemlock growth: possible tradeoffs in response of canopy trees to climate
Authors: Stern Rebecca L. , Schaberg Paul G. , Rayback Shelly A. , Murakami Paula F. , Hansen Christopher F. , Hawley Gary J. 
Published: August 2021

A warming climate and extended growing season may confer competitive advantages to temperate conifers that can photosynthesize across seasons. Whether this potential translates into increased growth is unclear, as is whether pollution could constrain growth. We examined two temperate conifers — eastern white pine (Pinus strobus L.) and eastern hemlock (Tsuga canadensis (L.) Carrière) — and analyzed associations between growth (476 trees in 23 plots) and numerous factors, including climate and pollutant deposition variables. Both species exhibited increasing growth over time and eastern white pine showed greater maximum growth. Higher spring temperatures were associated with greater growth for both species, as were higher autumnal temperatures for eastern hemlock. Negative correlations were observed with previous year (eastern hemlock) and current year (eastern white pine) summer temperatures. Spring and summer moisture availability were positively correlated with growth for eastern white pine throughout its chronology, whereas for hemlock, correlations with moisture shifted from being significant with current year’s growth to previous year’s growth over time. The growth of these temperate conifers might benefit from higher spring (both species) and fall (eastern hemlock) temperatures, though this could be offset by reductions in growth associated with hotter, drier summers.
Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity
Authors: Ketola Kirsi , Kaljunen Heidi , Taavitsainen Sinja , Kaarijärvi Roosa , Järvelä Emmi , Rodríguez-Martín Bernardo , Haase Kerstin , Woodcock Dan J. , Tubio Jose , Wedge David C. , Nykter Matti , Bova G. Steven 
Published: August 2021

AbstractTreatment-eradicated cancer subclones have been reported in leukemia and have recently been detected in solid tumors. Here we introduce Differential Subclone Eradication and Resistance (DSER) analysis, a method developed to identify molecular targets for improved therapy by direct comparison of genomic features of eradicated and resistant subclones in pre- and posttreatment samples from a patient with BRCA2-deficient metastatic prostate cancer. FANCI and EYA4 were identified as candidate DNA repair–related targets for converting subclones from resistant to eradicable, and RNAi-mediated depletion of FANCI confirmed it as a potential target. The EYA4 alteration was associated with adjacent L1 transposon insertion during cancer evolution upon treatment, raising questions surrounding the role of therapy in L1 activation. Both carboplatin and enzalutamide turned on L1 transposon machinery in LNCaP and VCaP but not in PC3 and 22Rv1 prostate cancer cell lines. L1 activation in LNCaP and VCaP was inhibited by the antiretroviral drug azidothymidine. L1 activation was also detected postcastration in LuCaP 77 and LuCaP 105 xenograft models and postchemotherapy in previously published time-series transcriptomic data from SCC25 head and neck cancer cells. In conclusion, DSER provides an informative intermediate step toward effective precision cancer medicine and should be tested in future studies, especially those including dramatic but temporary metastatic tumor regression. L1 transposon activation may be a modifiable source of cancer genomic heterogeneity, suggesting the potential of leveraging newly discovered triggers and blockers of L1 activity to overcome therapy resistance.Significance:Differential analysis of eradicated and resistant subclones following cancer treatment identifies that L1 activity associated with resistance is induced by current therapies and blocked by the antiretroviral drug azidothymidine.
Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence
Authors: Zhan Daqian , Ma Ding , Wei Shuang , Lal Bachchu , Fu Yi , Eberhart Charles , Laterra John , Ying Mingyao , Li Yunqing , Meeker Alan , Lopez-Bertoni Hernando , Xia Shuli 
Published: August 2021

Abstract

Heterozygous isocitrate dehydrogenase (IDH) R132H mutation (IDH1R132H/WT) is an early event during gliomagenesis. Clinically, patients with glioma carrying mutant IDH1 respond better to antitumor therapies. However, the mechanism by which IDH1 mutations contribute to gliomagenesis and therapeutic response remains elusive. Here we report that senescence is involved in the improved therapeutic responses of mutant IDH1 glioma cells. Knocking-in IDH1R132H/WT in glioma cells significantly enhanced gliomas cell senescence in response to temozolomide and radiation via a DNA-damage mediated mechanism. We further asked if senescence plays a role in IDH1R132H/WT-induced gliomagenesis. Together with ATRX knockout and p53/RB loss, IDH1R132H/WT transformed nonneoplastic human astroglial cells to form tumors in mouse brains. In-depth characterization revealed that a subset of these precancerous cells underwent senescence-like phenotypic changes, including flat and enlarged-cell morphology, increased senescence marker expression, decreased cell proliferation, and cell-cycle arrest at the G2–M phase. Mechanistic studies indicated that the combination of glioma driver genes (p53/RB/IDH1/ATRX) dramatically increased DNA damage and activated DNAdamage response (DDR) pathways ATR/ATR and Chk1/Chk2 in senescent cells. To determine how senescent cells drive tumor formation, we investigated non–cell-autonomous mechanisms such as senescence-associated secretory phenotype (SASP), a panel of proinflammatory and tissue-remodeling factors implicated in a tumor-permissive microenvironment. We found that astroglial cells carrying p53/RB/ATRX loss and IDH1R132H/WT upregulated key factors in SASP via an epigenetic-mediated mechanism. Our work suggests that drugs that specifically eliminate senescent cells could help kill precancerous cells and senescent tumor cells following antitumor therapies.

Implications:
The mechanisms by which IDH1 mutations contribute to gliomagenesis and therapeutic responses remain incompletely characterized; this work reveals senescence as a novel mechanism of IDH-mutant–mediated biological impact and describes new therapeutic opportunities concerning IDH1-mutant gliomas.
Weight Loss During Intrauterine Progestin Treatment for Obesity-associated Atypical Hyperplasia and Early-Stage Cancer of The Endometrium
Authors: Barr Chloe E. , Ryan Neil A.J. , Derbyshire A.E. , Wan Y. Louise , MacKintosh Michelle L. , McVey Rhona J. , Bolton James , Fitzgerald Cheryl , Awad Dina , Slade Richard J. , Syed Akheel A. , Ammori Basil J. , Crosbie Emma J. 
Published: August 2021

Abstract

Intrauterine progestin is a treatment option for women with atypical hyperplasia or low-risk endometrial cancer who wish to preserve their fertility, or whose poor surgical fitness precludes safe hysterectomy. We hypothesized that in such women with obesity, weight loss during progestin treatment may improve oncological outcomes. We conducted a prospective nonrandomized study of women with obesity and atypical hyperplasia or low-grade stage 1a endometrial cancer undergoing progestin treatment. Women with a body mass index (BMI) ≥ 35 kg/m2 were offered bariatric surgery; those who declined and those with a BMI of 30 to 34.9 kg/m2 were encouraged to lose weight by low-calorie diet. We assessed uptake of bariatric surgery; weight lost during progestin treatment; and the impact of more than 10% total body weight loss on progestin treatment response at 12 months. 71 women [median age 58 years (interquartile range; IQR 35–65); mean BMI 48 kg/m2 (SD 9.3)] completed the study. Twenty-three women (32%) had bariatric surgery, on average 5 months (IQR 3–8) after progestin treatment commenced. Weight change during progestin treatment was −33.4 kg [95% confidence interval (CI) −42.1, −24.7] and −4.6 kg (95% CI −7.8, −1.4) in women receiving bariatric surgery and low-calorie diet, respectively (P &lt; 0.001). Forty-three women (61%) responded to progestin, while 23 (32%) showed stabilized and 5 (7%) progressive disease. Response at 12 months was not predicted by age or baseline BMI, but women who lost more than 10% of their total body weight were more likely to respond to progestin than those who did not (adjusted odds ratio 3.95; 95% CI 1.3, 12.5; P = 0.02). Thus weight loss may improve oncological outcomes in women with obesity-associated endometrial neoplastic abnormalities treated with progestin.

Prevention Relevance:
This study found that weight loss improves response rates in women with obesity and atypical hyperplasia or low-risk endometrial cancer undergoing conservative management with intrauterine progestin. Given the additional benefits of weight loss for fertility, cardiovascular health and quality of life, future research should focus on how best to accomplish it.
Prevalence, Characteristics, and Outcomes of Undetermined Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis
Authors: Malhotra Konark , Zompola Christina , Theodorou Aikaterini , Katsanos Aristeidis H. , Shoamanesh Ashkan , Gupta Himanshu , Beshara Simon , Goyal Nitin , Chang Jason , Tayal Ashis H. , Boviatsis Efstathios , Voumvourakis Konstantinos , Cordonnier Charlotte , Werring David J. , Alexandrov Andrei V. , Tsivgoulis Georgios 
Published: August 2021

Background and Purpose:
There are scarce data regarding the prevalence, characteristics and outcomes of intracerebral hemorrhage (ICH) of undetermined (unknown or cryptogenic) etiology. We sought to determine the prevalence, radiological characteristics, and clinical outcomes of undetermined ICH.

Methods:

Systematic review and meta-analysis of studies involving patients with spontaneous ICH was conducted to primarily assess the prevalence and clinical-radiological characteristics of undetermined ICH. Additionally, we assessed the rates for ICH secondary to hypertensive arteriopathy and cerebral amyloid angiopathy. Subgroup analyses were performed based on the use of (1) etiology-oriented ICH classification, (2) detailed neuroimaging, and (3) Boston criteria among patients with cerebral amyloid angiopathy related ICH. We pooled the prevalence rates using random-effects models, and assessed the heterogeneity using Cochran
Q
and
I
2
statistics.

Results:

We identified 24 studies comprising 15 828 spontaneous ICH patients (mean age, 64.8 years; men, 60.8%). The pooled prevalences of hypertensive arteriopathy ICH, undetermined ICH, and cerebral amyloid angiopathy ICH were 50% (95% CI, 43%–58%), 18% (95% CI, 13%–23%), and 12% (95% CI, 7%–17% [
P
<0.001 between subgroups]). The volume of ICH was the largest in cerebral amyloid angiopathy ICH (24.7 [95% CI, 19.7–29.8] mL), followed by hypertensive arteriopathy ICH (16.2 [95% CI, 10.9–21.5] mL) and undetermined ICH (15.4 [95% CI, 6.2–24.5] mL). Among patients with undetermined ICH, the rates of short-term mortality (within 3 months) and concomitant intraventricular hemorrhage were 33% (95% CI, 25%–42%) and 38% (95% CI, 28%–48%), respectively. Subgroup analysis demonstrated a higher rate of undetermined ICH among studies that did not use an etiology-oriented classification (22% [95% CI, 15%–29%]). No difference was observed between studies based on the completion of detailed neuroimaging to assess the rates of undetermined ICH (
P
=0.62).

Conclusions:
The etiology of spontaneous ICH remains unknown or cryptogenic among 1 in 7 patients in studies using etiology-oriented classification and among 1 in 4 patients in studies that avoid using etiology-oriented classification. The short-term mortality in undetermined ICH is high despite the relatively small ICH volume.
Embodied Becoming – Student Teachers’ Reflections on Their Filmed Teaching
Authors: Cronqvist Marita 
Published: August 2021

Abstract
This study examines student teachers’ reflections on recordings of their teaching during a period of internship related to a subject didactic course in Swedish. Bodily expressions, not as frequently explored as verbal ones, are in focus. Data consists of video papers, multimedia documents, combining clips of video recordings and reflective texts on the clips. The purpose is to gain knowledge about student teachers’ reflections on and learning of bodily expressions in teaching, using video papers. The analysis of the video papers is descriptive phenomenological, searching for the meanings of the phenomenon. The findings indicate that video papers contribute to student teachers’ reflections and learning about bodily expressions in terms of how they move in front of students, what impressions their bodies convey, how they manage to make contact and how they use their voices. Video papers complement the memory image and through recordings, bodily expressions get attention and are verbalized.
Access to Information and Other Correlates of Vote Buying and Selling Behaviour: Insights from Philippine Data
Authors: Canare Tristan , Mendoza Ronald U. 
Published: August 2021

Access to information is a key factor influencing political behaviour and decisions. Recent studies on vote buying and selling have tried to unpack the possible drivers behind this phenomenon; yet, few studies have empirically examined the role of different sources of information. This study contributes to the nascent literature in this area by turning to a unique dataset from a survey of low-income voters in Metro Manila, the Philippines. It empirically examined the relationship between access to information and vote selling behaviour by low-income voters. It also studied other correlates of vote selling and the possible factors linked to receiving an offer. The results suggest that the quantity of information has no significant relationship with the likelihood of accepting the offer and voting for the candidate for whom the offer was made. However, the quality of information does matter. In particular, access to sources of ‘good quality information’ is negatively associated with completing the vote selling transaction (i.e., accepting the offer and voting for the candidate). This study also found evidence that when money is used for vote buying, it appears to be targeted at those with greater needs, confirming the literature that vote buying activities tend to be well targeted at poor and low-income communities. Unsurprisingly, vote buying offers are more likely in areas where elections are closely contested, and they are also more likely in socially cohesive communities. Our findings also suggest that vote buying may not necessarily be effective in the sense that it encourages only few voters to change their candidate preference. This coheres with earlier studies suggesting that vote buying and selling merely caps a longstanding patron–client relationship between politicians and low-income voters. JEL: D72, D91, K49