bluuebunny/crossref_metadata_2025_split huggingface dataset:
The remarkably frequent use of EQ-5D in non-economic research
Authors: Wang Aimin , Rand Kim , Yang Zhihao , Brooks Richard , Busschbach Jan 
Published: November 2021

Abstract
Introduction
EQ-5D is an instrument which has been utilized for a variety of purposes, including in health-economic appraisals as an input into quality-adjusted life year (QALY) calculations. Indeed, it is the most-widely applied instrument for health-economic appraisal worldwide, and is recommended for use in QALY calculations by many national Health Technology Assessment (HTA) agencies. There is also a growing body of evidence for its usefulness in a variety of settings other than economic appraisals, but such use has not been well-documented. This study addresses this issue and documents how EQ-5D has been applied in both the non-economic and economic contexts.

Methods
The PubMed database was searched using the terms ‘EQ-5D’, ‘EQ-5D AND cost’, and ‘EQ-5D AND cost AND QALY’ from 1 January 1980 to 31 December 2019. We concentrated on 2019 publications for more detailed analyses. All the data collected for 2019 were downloaded and collected in EndNote. For 2019 only, we classified economic and non-economic use based on the inclusion of ‘cost’. We also checked by manual inspection whether the search terms were suitable in correctly identifying economic and non-economic use. Variants of the non-economic use of EQ-5D were classified as follows: (a) as a quality of life outcome measure; (b) as a tool for methodological research; (c) methodological issues of EQ-5D itself; (d) comparisons with other quality of life questionnaires; (e) mapping studies; (f) value sets; (g) alongside costs but no QALY calculated; and (h) other.

Results
The first publication found was from 1990. Up to and including 2019, 10,817 publications were identified, of which more than two in three did not contain any reference to costs or QALYs. In 2019, a total of 1409 manuscripts were identified, of which 239 were specifically for EQ-5D-5L. Four hundred and seven (28.9%) included some form of ‘costs’ and 157 (11.1%) both ‘costs’ AND ‘QALYs’ terms. For EQ-5D-5L, the corresponding numbers were 104 (43.5%) and 29 (12.1%), respectively. After manually checking all the 1409 papers, three were duplicated records, which were omitted. In the remaining 1406 papers, only 40 (2.8%) contained the term ‘cost’, but not ‘cost per QALY’, and only 117 (8.3%) were identifiable as economic evaluations using the term ‘cost per QALY’. Most non-economic use of EQ-5D was as a quality-of-life outcome measure (72.8%). Other applications were: as a tool for methodological research (6.7%); comparison studies (3.7%); EQ-5D methodological issues (3.5%); containing costs but not QALYs (2.8%); mapping (1.3%); value sets (0.4%); and other papers (0.4%).

Conclusions
The majority of the studies retrieved, covering a wide variety of research areas, reported upon the non-economic use of EQ-5D. Despite being the most-used instrument worldwide for QALY calculations, economic appraisal accounted for only a small, but important, part of published use.
Income level and antibiotic misuse: a systematic review and dose–response meta-analysis
Authors: Mallah Narmeen , Orsini Nicola , Figueiras Adolfo , Takkouche Bahi 
Published: November 2021

Abstract
Objectives
To quantify the association between income and antibiotic misuse including unprescribed use, storage of antibiotics and non-adherence.

Methods
We identified pertinent studies through database search, and manual examination of reference lists of selected articles and review reports. We performed a dose–response meta-analysis of income, both continuous and categorical, in relation to antibiotic misuse. Summary odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated under a random-effects random effects model.

Results
Fifty-seven studies from 22 countries of different economic class were included. Overall, the data are in agreement with a flat linear association between income standardized to socio-economic indicators and antibiotic misuse (OR per 1 unit increment = 1.00, p-value = 0.954, p-value non-linearity = 0.429). Data were compatible with no association between medium and high income with general antibiotic misuse (OR 1.04; 95% CI 0.89, 1.20 and OR 1.03; 95% CI 0.82, 1.29). Medium income was associated with 19% higher odds of antibiotic storage (OR 1.19; 95% CI 1.07, 1.32) and 18% higher odds of any aspect of antibiotic misuse in African studies (OR 1.18; 95% CI 1.00, 1.39). High income was associated with 51% lower odds of non-adherence to antibiotic treatment (OR 0.49; 95% CI 0.34, 0.60). High income was also associated with 11% higher odds of any antibiotic misuse in upper-middle wealth countries (OR 1.11; 95% CI 1.00, 1.22).

Conclusions
The association between income and antibiotic misuse varies by type of misuse and country wellness. Understanding the socioeconomic properties of antibiotic misuse should prove useful in developing related intervention programs and health policies.
Simulated encounters with a novel competitor reveal the potential for maladaptive behavioural responses to invasive species
Authors: Champneys T. , Ferry K. , Tomkinson S. , Genner M. J. , Ioannou C. C. 
Published: November 2021

AbstractDuring the early stage of biological invasions, interactions occur between native and non-native species that do not share an evolutionary history. This can result in ecological naïveté, causing native species to exhibit maladaptive behavioural responses to novel enemies, leading to negative consequences for individual fitness and ecosystem function. The behavioural response of native to non-native species during novel encounters can determine the impact of non-native species, and restrict or facilitate their establishment. In this study we simulated novel encounters between a widespread invasive fish species, the Nile tilapia (Oreochromis niloticus), and a threatened native Manyara tilapia (Oreochromis amphimelas). In the first experiment single adult O. niloticus were presented with a stimulus chamber (a transparent plastic cylinder) which was empty during control trials and contained a pair of juvenile O. amphimelas in stimulus trials. In the second experiment, the reciprocal set up was used, with pairs of juvenile O. amphimelas as the focal species and adult O. niloticus as the stimulus. Both species approached the stimulus chamber more readily during stimulus trials, a behavioural response which would increase the prevalence of interspecific interactions in situ. This included physical aggression, observed from the competitively dominant O. niloticus towards O. amphimelas. Despite an initial lack of fear shown by O. amphimelas, close inspection of the stimulus chamber often resulted in an energetically costly dart response. Under field conditions we predict that naïve native individuals may readily approach O. niloticus, increasing the likelihood of interactions and exacerbating widely reported negative outcomes.
The importance of allochthonous organic matter quality when investigating pulse disturbance events in freshwater lakes: a mesocosm experiment
Authors: Calderó-Pascual Maria , Yıldız Dilvin , Yalçın Gülce , Metin Melisa , Yetim Sinem , Fiorentin Claudia , Andersen Mikkel René , Jennings Eleanor , Jeppesen Erik , Ger Kemal Ali , Beklioğlu Meryem , McCarthy Valerie 
Published: November 2021

AbstractExtreme precipitation is occurring with greater frequency and intensity as a result of climate change. Such events boost the transport of allochthonous organic matter (allo-OM) to freshwater ecosystems, yet little is known about the impacts on dissolved organic matter (DOM) quality and seston elemental stoichiometry, especially for lakes in warm climates. A mesocosm experiment located in a Turkish freshwater lake was designed to simulate a pulse event leading to increased inputs of allo-OM by examining the individual effects of increasing water colour (HuminFeed®, HF), the direct effects of the extra energetic inputs (alder tree leaf leachate, L), and the interactions of the single treatment effects (combination of both sources, HFL), along with a comparison with unmanipulated controls. Changes in the DOM quality and nutrient stoichiometry of the allo-OM treatment additions was examined over the course of the experiments. Results indicated that there was an increase of high recalcitrant DOM components in the HF treatment, in contrast to an increase in less aromatic microbially derived molecules for the L treatment. Unexpectedly, seston C:P ratios remained below a severe P-limiting threshold for plankton growth and showed the same temporal pattern in all mesocosms. In contrast, seston N:P ratios differed significantly between treatments, with the L treatment reducing P-limiting conditions, whilst the HF treatment increased them. The effects of the combined HFL treatment indicated an additive type of interaction and chlorophyll-awas highest in the HFL treatment. Our results demonstrate that accounting for the optical and stoichiometric properties of experimental allo-OM treatments is crucial to improve the capacity to explain extrapolated conclusions regarding the effects of climate driven flooding on freshwater ecosystems in response to global climate change.Graphical abstract
Bioflocculation of Euglena gracilis via direct application of fungal filaments: a rapid harvesting method
Authors: Bansfield Danielle , Spilling Kristian , Mikola Anna , Piiparinen Jonna 
Published: November 2021

AbstractThe high cost and environmental impact of traditional microalgal harvesting methods limit commercialization of microalgal biomass. Fungal bioflocculation of microalgae is a promising low-cost, eco-friendly method but the range of fungal and microalgal species tested to date is narrow. Here, eight non-pathogenic, filamentous fungi were screened for their ability to self-pelletize and flocculate Euglena gracilis (ca.50 µm motile microalga) in suspension. Self-pelletization was tested under various rotational speeds, and species which formed pellets (Ø > 0.5 cm) were selected for harvesting tests. Filaments of each species were combined with E. gracilis at various ratios based on dry weight. Harvesting efficiency was determined by measuring the change in cell counts over time, and settling of the flocs was evaluated by batch settling tests. Three fungal species, Ganoderma lucidum, Pleurotus ostreatus, and Penicillium restrictum, were able to reliably flocculate and harvest 62–75% of the microalgae while leaving it unharmed. The results demonstrated that self-pelletization, harvesting, and settling were dependent on the fungal species. The fungi to algae ratio also had significant but contrasting effects on harvesting and settling. In balancing the needs to both harvest and settle the biomass, the optimal fungi to algae ratio was 1:2. The application of fungal filaments to microalgae in suspension produced readily settling flocs and was less time-consuming than other commonly used methods. This method is especially attractive for harvesting microalgal biomass for low-value products where speed, low cost, and cell integrity is vital.
The Importance of the Neighbourhood Environment and Social Capital for Happiness in a Vulnerable District: The Case of the Pajarillos District in Spain
Authors: Somarriba Arechavala Noelia , Zarzosa Espina Pilar , López Pastor Ana Teresa 
Published: November 2021

AbstractThe characteristics of neighbourhoods, their physical and social environment, have been shown to have profound effects on the individual well-being and happiness of their residents. In an effort to help design policies and action plans that enhance well-being in the district, our study seeks to understand how happiness levels among residents in a low-income neighbourhood in Spain are linked to their socio-demographic traits, individual health, relationships with the area, and community, as well as with the physical environment of the neighbourhood. The study is part of a project called "Educa-Pajarillos Sostenible". The project aims to improve the quality of life of the area’s citizens by carrying out a series of actions. One of these actions is an eco-social map of happiness, which involves designing and applying a survey and which serves as a source of analysis for our research. An Ordered Choice Logit econometric model was applied to measure the effect of the happiness of demographic, neighbourhood environment, social capital, and socio-demographic characteristics. Results confirm the importance of variables related to the neighbourhood’s social capital and physical environment as key elements in local residents’ happiness. The findings also indicate that traditional indicators used to measure well-being, such as education or difficulty making ends meet, are not significant.
Learning to Litigate: the Relationship Between Past Litigation Experience and Litigation Outcomes in the Chinese Intellectual Property System
Authors: Vaarst Andersen Kristina , Beukel Karin , Tyler Beverly B. 
Published: November 2021

AbstractIntellectual property (IP) and the protection of IP is of increasing importance to firms’ competitiveness, and firms must be able to defend their IP when it is infringed upon. In most markets, IP and the defense of IP is a stringent legal process, but in developing markets and markets undergoing changes, this is not necessarily so. The Chinese IP system and protection is comparatively new, and the system is still under development. In this study, we analyze the relationship between firms’ previous litigation experience and litigation outcomes using a sample of 10,211 court cases tried in China between 2001 and 2009. We find that despite litigation being a rare event for most firms, plaintiffs’ prior litigation experience and especially prior successful litigation experience or experience with specific case types is related to their likelihood of a positive outcome. However, plaintiffs’ successful application of prior litigation experience is contingent on the type of litigation case.
Völkische Esoterik und Transzendentalisierung der Nation als antisemitische Schuldabwehr in Ungarn
Authors: Marsovszky Magdalena 
Published: November 2021

ZusammenfassungDie völkische Esoterik als Alltagsreligion ist gegenwärtig die prägnanteste Manifestation der antisemitischen Schuldabwehr in Ungarn. Als wahnhaftes Phantasma bekam sie Eingang ins neue Grundgesetz (2012) und bestimmt als staatsrechtliche Grundlage das politische und kulturelle Leben Ungarns. Da sie die Wirklichkeit zu entstellen vermag, wurde sie zur Norm einer destruktiven, negativen Integration, in der Menschengruppen durch gemeinsame Wutprojektionen zueinander finden. Ihr Ziel ist die Herstellung einer vorgestellten, letztendlich, durch die „heilige Krone“ kosmisch gesteuerten völkisch-arischen Harmonie, mit einem Homogenitätsversprechen gleich, das nur durch die Entfernung der als nicht-identisch fantasierten „Lebensunwerten“ erfüllbar zu sein scheint.Im Beitrag werden die strukturellen Elemente der völkischen Esoterik in Ungarn herausgearbeitet und dargelegt, warum diese Ideologie mit der von der Orbán-Regierung beschworenen christlich-demokratischen Politik unvereinbar ist und der Antisemitismus in ihr immanent enthalten ist.

Sie propagiert statt christlicher Nächstenliebe „Artenliebe“.

Sie verkehrt die christliche Lehre radikal in ihr Gegenteil, weil sie die kulturpessimistische Annahme vertritt, dass die christliche Erlösung versagt hätte, weil die Gegenwart degeneriert und entspiritualisiert sei, deshalb müsse die Welt durch einen spirituellen, charismatischen Führer erneut erlöst werden.

Erlösung bedeutet hier nicht die christliche Befreiung von den Sünden nach dem Tode, sondern die Reinkarnation, an der aber nur die „Artgleichen“ teilhaben können.

In ihr wird das Christentum von seiner jüdischen Herkunft „gereinigt“, selbst Jesus erscheint „entjudet“ als „parthischer Prinz“ und Arier.

Ihr „Universalismus“ ist gegenaufklärerisch-identitär.
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
Authors: Cho Yongsik , Jeong Sumin , Kim Hyeonkyeong , Kang Donghyun , Lee Jeeyeon , Kang Seung-Baik , Kim Jin-Hong 
Published: November 2021

AbstractOsteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive destruction of articular cartilage and the development of chronic pain and constitutes a considerable socioeconomic burden. Currently, pharmacological treatments mostly aim to relieve the OA symptoms associated with inflammation and pain. However, with increasing understanding of OA pathology, several potential therapeutic targets have been identified, enabling the development of disease-modifying OA drugs (DMOADs). By targeting inflammatory cytokines, matrix-degrading enzymes, the Wnt pathway, and OA-associated pain, DMOADs successfully modulate the degenerative changes in osteoarthritic cartilage. Moreover, regenerative approaches aim to counterbalance the loss of cartilage matrix by stimulating chondrogenesis in endogenous stem cells and matrix anabolism in chondrocytes. Emerging strategies include the development of senolytic drugs or RNA therapeutics to eliminate the cellular or molecular sources of factors driving OA. This review describes the current developmental status of DMOADs and the corresponding results from preclinical and clinical trials and discusses the potential of emerging therapeutic approaches to treat OA.
Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress
Authors: Caradonna Salvatore G. , Zhang Tie-Yuan , O’Toole Nicholas , Shen Mo-Jun , Khalil Huzefa , Einhorn Nathan R. , Wen Xianglan , Parent Carine , Lee Francis S. , Akil Huda , Meaney Michael J. , McEwen Bruce S. , Marrocco Jordan 
Published: November 2021

AbstractThe multifactorial etiology of stress-related disorders necessitates a constant interrogation of the molecular convergences in preclinical models of stress that use disparate paradigms as stressors spanning from environmental challenges to genetic predisposition to hormonal signaling. Using RNA-sequencing, we investigated the genomic signatures in the ventral hippocampus common to mouse models of stress. Chronic oral corticosterone (CORT) induced increased anxiety- and depression-like behavior in wild-type male mice and male mice heterozygous for the gene coding for brain-derived neurotrophic factor Val66Met, a variant associated with genetic susceptibility to stress. In a separate set of male mice, chronic social defeat stress (CSDS) led to a susceptible or a resilient population, whose proportion was dependent on housing conditions, namely standard housing or enriched environment. Rank-rank-hypergeometric overlap (RRHO), a threshold-free approach that ranks genes by their p value and effect size direction, was used to identify genes from a continuous gradient of significancy that were concordant across groups. In mice treated with CORT and in standard-housed susceptible mice, differentially expressed genes (DEGs) were concordant for gene networks involved in neurotransmission, cytoskeleton function, and vascularization. Weighted gene co-expression analysis generated 54 gene hub modules and revealed two modules in which both CORT and CSDS-induced enrichment in DEGs, whose function was concordant with the RRHO predictions, and correlated with behavioral resilience or susceptibility. These data showed transcriptional concordance across models in which the stress coping depends upon hormonal, environmental, or genetic factors revealing common genomic drivers that embody the multifaceted nature of stress-related disorders.
The JAK/STAT signaling pathway: from bench to clinic
Authors: Hu Xiaoyi , li Jing , Fu Maorong , Zhao Xia , Wang Wei 
Published: November 2021

AbstractThe Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state
Authors: Liu Zhiyuan , Le Qiumin , Lv Yanbo , Chen Xi , Cui Jian , Zhou Yiming , Cheng Deqin , Ma Chaonan , Su Xiujuan , Xiao Lei , Yang Ruyi , Zhang Jiayi , Ma Lan , Liu Xing 
Published: November 2021

AbstractDopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release and augment rewards. However, how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive. Here we report that the ventral pallidum (VP) projection of NAc D1-MSNs (D1NAc-VP) is inhibited by rewarding stimuli and activated by aversive stimuli. In contrast to the VM projection of D1-MSN (D1NAc-VM), activation of D1NAc-VP projection induces aversion, but not reward. D1NAc-VP MSNs are distinct from the D1NAc-VM MSNs, which exhibit conventional functions of D1-MSNs. Activation of D1NAc-VP projection stimulates VM GABAergic transmission, inhibits VM DAergic neurons, and reduces DA release into the NAc. Thus, D1NAc-VP and D1NAc-VM MSNs cooperatively control NAc dopamine balance and reward-aversion states.
Microbiologically influenced corrosion inhibition of carbon steel via biomineralization induced by Shewanella putrefaciens
Authors: Lou Yuntian , Chang Weiwei , Cui Tianyu , Qian Hongchang , Huang Luyao , Ma Lingwei , Hao Xiangping , Zhang Dawei 
Published: November 2021

AbstractMicrobiologically influenced corrosion inhibition (MICI) of Q235 carbon steel by biomineralization was investigated via a combination of surface analysis, electrochemistry, and scanning electrochemical microscopy (SECM). The results showed that Shewanella putrefaciens used the cell walls as the nucleation sites to induce the formation of a protective biomineralized layers which contained calcite and extracellular polymeric substances on the steel surface. The potentiodynamic polarization results demonstrated that the corrosion current density (icorr value) of the biomineralized steel surface was 0.38 μA cm−2, which was less than one-tenth that of the blank steel in a sterile medium (4.86 μA cm−2) after 14 days. The biomineralized layers presented wear resistance and could self-repair after undergoing mechanical damage under microbial conditions as verified by morphological and SECM observations. This work reveals that microbial-induced carbonate biomineralization, as a MICI approach, may be considered as a reliable, low-cost, environmentally friendly corrosion inhibition strategy.