bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heated tobacco product use and hypertensive disorders of pregnancy and low birth weight: analysis of a cross-sectional, web-based survey in Japan
Authors: Zaitsu Masayoshi , Hosokawa Yoshihiko , Okawa Sumiyo , Hori Ai , Kobashi Gen , Tabuchi Takahiro 
Published: September 2021

ObjectivesKnowledge on the impact of heated tobacco product (HTP) use in pregnant women with associated maternal and neonatal risks for hypertensive disorders of pregnancy (HDP) and low birth weight (LBW) is limited. We aimed to assess the status of HTP use among pregnant women in Japan and explore the association of HTP use with HDP and LBW.DesignCross-sectional study.SettingData from the Japan ‘COVID-19 and Society’ Internet Survey study, a web-based nationwide survey.ParticipantsWe investigated 558 postdelivery and 365 currently pregnant women in October 2020.Primary and secondary outcome measuresInformation on HDP and LBW was collected from the postdelivery women’s Maternal and Child Health Handbooks (maternal and newborn records). We estimated the age-adjusted ORs and 95% CIs of ever HTP smokers for HDP and LBW and compared them with those of never HTP smokers in a logistic regression analysis.ResultsThe prevalence of ever and current HTP use were 11.7% and 2.7% in postdelivery women and 12.6% and 1.1% in currently pregnant women, respectively. Among currently pregnant women who were former combustible cigarette smokers, 4.4% (4/91) were current HTP smokers. Among postdelivery women, ever HTP smokers had a higher HDP incidence (13.8% vs 6.5%, p=0.03; age-adjusted OR=2.48, 95% CI 1.11 to 5.53) and higher LBW incidence (18.5% vs 8.9%, p=0.02; age-adjusted OR=2.36, 95% CI 1.16 to 4.87).ConclusionsIn Japan, the incidence of ever HTP use exceeded 10% among pregnant women, and HTP smoking may be associated with maternal and neonatal risks.
Effectiveness of a brief positive skills intervention to improve psychological adjustment in patients with end-stage kidney disease newly initiated on haemodialysis: protocol for a randomised controlled trial (HED-Start)
Authors: Griva Konstadina , Chia Jace Ming Xuan , Goh Zack Zhong Sheng , Wong Yen Peng , Loei Job , Thach Thuan Quoc , Chua Wei Bin , Khan Behram A 
Published: September 2021

IntroductionInitiation onto haemodialysis is a critical transition that entails multiple psychosocial and behavioural demands that can compound mental health burden. Interventions guided by self-management and cognitive–behavioural therapy to improve distress have been variably effective yet are resource-intensive or delivered reactively. Interventions with a focus on positive affect for patients with end-stage kidney disease are lacking. This study will seek (1) to develop a positive life skills intervention (HED-Start) combining evidence and stakeholder/user involvement and (2) evaluate the effectiveness of HED-Start to facilitate positive life skills acquisition and improve symptoms of distress and adjustment in incident haemodialysis patients.Methods and analysisThis is a single/assessor-blinded randomised controlled trial (RCT) to compare HED-Start to usual care. In designing HED-Start, semistructured interviews, a codesign workshop and an internal pilot will be undertaken, followed by a two-arm parallel RCT to evaluate the effectiveness of HED-Start. A total of 148 incident HD patients will be randomised using a 1:2 ratio into usual care versus HED-Start to be delivered in groups by trained facilitators between January 2021 and September 2022. Anxiety and depression will be the primary outcomes; secondary outcomes will be positive and negative affect, quality of life, illness perceptions, self-efficacy, self-management skills, benefit finding and resilience. Assessments will be taken at 2 weeks prerandomisation (baseline) and 3 months postrandomisation (2 weeks post-HED-Start completion). Primary analyses will use an intention-to-treat approach and compare changes in outcomes from baseline to follow-up relative to the control group using mixed-effect models.Ethics and disseminationEthics approval was obtained from Nanyang Technological University Institutional Review Board (IRB-2019-01-010). Written informed consent will be obtained before any research activities. Trial results will be disseminated via publications in peer-reviewed journals and conference presentations and will inform revision(s) in renal health services to support the transition of new patients to haemodialysis.Trial registration numberNCT04774770.
Mental health in the second year of the COVID-19 pandemic: protocol for a nationally representative multilevel survey in Serbia
Authors: Marić Nadja P , Lazarević Ljiljana B , Mihić Ljiljana , Pejovic Milovancevic Milica , Terzić Zorica , Tošković Oliver , Todorović Jovana , Vuković Olivera , Knezevic Goran 
Published: September 2021

IntroductionThe COVID-19 pandemic is likely to have a prolonged impact on mental health (MH); however, the long-term MH effects of the COVID-19 pandemic remain unknown. The Serbian national survey—CoV2Soul.RS—was launched to document the MH status of the Serbian population following the COVID-19 pandemic and to contribute to an international evidence base about MH prevalence rates during different phases of the pandemic.Methods and analysisThis cross-sectional study was designed to collect a nationally representative sample (N=1200; age 18–65 years; estimated start/end—June/November 2021) using multistage probabilistic household sampling. Trained staff will conduct in-person diagnostic interviews. A battery of self-report instruments will be administered to assess the quality of life (QoL), general distress and associated protective and harmful psychological and societal factors. Analyses will be conducted to delineate the prevalence rates of MH disorders, how MH conditions and QoL vary with respect to sociodemographic variables, personality, health status and traumatic events during the COVID-19 pandemic, and to test how these relations depend on geographical region. Moreover, this study was designed to explore mechanisms linking personality and the perception of pandemic consequences and associated distress. Prevalence rates of MH disorders will be calculated using descriptive statistics. For additional analyses, we will use correlations, analysis of variance and regression analyses. The hierarchical structure of the data will be explored using multilevel random coefficient modelling. Structural equation modelling will be used to investigate the indirect effects of personality on distress through relevant variables.Ethics and disseminationEthical Committees of the Faculty of Medicine (1322-VII/31) and Faculty of Philosophy in Belgrade (02-33/273) and Faculty of Philosophy in Novi Sad (05-27, br.893/1) approved the protocol. Only respondents able to provide informed consent will participate in the study. Research reports will be submitted to peer-reviewed journals and the results will be placed on the websitewww.cov2soul.rsto be available to funders, researchers, policy-makers and interested laypeople, and will be advertised through social media.Trial registration numberNCT04896983.
Anxiety and depression among healthcare workers during the COVID-19 pandemic: a systematic umbrella review of the global evidence
Authors: Fernandez Ritin , Sikhosana Nqobile , Green Heidi , Halcomb Elizabeth J , Middleton Rebekkah , Alananzeh Ibrahim , Trakis Stamatia , Moxham L 
Published: September 2021

ObjectivesTo summarise the evidence relating to the prevalence of anxiety and depression among healthcare workers (HCWs) during the COVID-19 pandemic.DesignAn umbrella review of systematic reviews was undertaken using the Joanna Briggs Institute (JBI) methods.Data sourcesThe Cochrane database of systematic reviews, JBI Evidence Synthesis, MEDLINE, Web of Science, PsycINFO, Embase and CINAHL were searched in March 2021 for reviews published in English.Eligibility criteriaSystematic reviews reporting the prevalence of anxiety and depression among HCWs during the COVID-19 pandemic. Two researchers screened each abstract and independently reviewed full text articles. Study quality was assessed using the JBI critical appraisal tool for systematic reviews, and the degree of overlap in primary studies was calculated.ResultsTen systematic reviews (100 unique studies), including 169 157 HCWs from 35 countries were included. The prevalence of anxiety among all HCWs ranged from 22.2% (95% CI 21.3% to 23.1%) to 33.0% (95% CI 31.9% to 34.1%). The prevalence of anxiety among physicians (n=5820) was reported to be between 17% and 19.8% and for nurses (n=14 938) between 22.8% and 27%. The prevalence of depression among all HCWs ranged from 17.9% (95% CI 17.1% to 18.8%) to 36% (95% CI 34.9% to 37.1%). The prevalence of depression among physicians (n=643) and nurses (n=8063) was reported to be 40.4% and 28%, respectively.ConclusionsThere is wide variation evident in the presence of anxiety and depression among HCWs. In particular, the prevalence of depression among physicians was high. Strategies to reduce the incidence of anxiety and depression are urgently required.PROSPERO registration numberCRD42021238960.
Interaction between cement clinker constituents and clay minerals and their influence on the strength of cement-based stabilized soft clay
Authors: Wu Jun , Deng Zuhua , Deng Yongfeng , Zhou Annan , Zhang Yunsheng 
Published: September 2021

The strength of cement-based stabilized clay is less than that of concrete and mortar and shows a distinct variability owing to the existence of various clay minerals. To better understand the cement–clay reactions and the strength generation, two artificial clays with the unique clay mineral and major strength-producing constituents of cement clinker were investigated via mechanical, compositional, and microstructural analyses. Results show that C3A-stabilized clay gains strength rapidly in the first 3 days, but this favourable tendency vanishes over time. After 90 days of curing, the strength of C3S-stabilized clay is about four times that of the corresponding C3A-stabilized clay, indicating the remarkable long-term stabilization efficiency of C3S. Furthermore, clay minerals primarily draw into strength evolution in the reaction process. Despite that bentonite is more reactive than kaolin as long as the highly alkaline conditions persist, it has a higher probability to flocculate into large aggregates during the mixing process, which may impair the reaction efficiency and even brings adverse stabilization effects, suggesting the importance of uniformity control.
Anisotropic constant-roll inflation for the Dirac–Born–Infeld model
Authors: Nguyen Duy H. , Pham Tuyen M. , Do Tuan Q. 
Published: September 2021

AbstractIn this paper, we study a non-canonical extension of a supergravity-motivated model acting as a vivid counterexample to the cosmic no-hair conjecture due to its unusual coupling between scalar and electromagnetic fields. In particular, a canonical scalar field is replaced by the string-inspired Dirac–Born–Infeld one in this extension. As a result, exact anisotropic inflationary solutions for this Dirac–Born–Infeld model are figured out under a constant-roll condition. Furthermore, numerical calculations are performed to verify that these anisotropic constant-roll solutions are indeed attractive during their inflationary phase.
The new innovative optic complete method of identification of oil and its fraction
Authors: Ahmadova Kh. N. 
Published: September 2021

Development and demonstration of a new method for highly accurate forecasting of the hydrocarbon composition of oil based on determining the spectrum of its universal material constant–dielectric function, as by direct measurement using the method of spectroscopic ellipsometry, are today accepted as the world standard for determining the optical functions of any substance in a liquid or solid state, and by its quantum-mechanical calculation from first principles to complete coincidence with the measurement results. A methodology will be proposed for the complete description of any oil and the identification of it belonging to a particular oilfield. The methodology is not only universal and highly accurate, but also economical. In this work, we obtained several groups of fractions of crude oilsamples from different oil fields in Azerbaijan, which were accessed by spectroscopic ellipsometry over the 1.5–6.5 eV spectral range at room-temperature. Optical constants and dielectric function were obtained for massive samples of each substance and fractions. The proposed method is a complete dielectric fingerprint of oils for widespread use, including for environmental monitoring of oil-contaminated areas of the sea and land.
Three Mediating Pathways of Anxiety and Security in the Relationship between Coping Style and Disordered Eating Behaviors among Chinese Female College Students
Authors: Han Wenyue , Zheng Zheng , Zhang Ning 
Published: September 2021

Background. According to previous studies, eating disorders and disordered eating behaviors are associated with coping style, anxiety, and sense of security. However, the specific mechanism between them has not been elucidated. The purpose of this study was to explore whether anxiety and sense of security play mediating roles in coping style and disordered eating behaviors among Chinese female college students. Method. Six hundred and ninety-one female college students (

mean

age
=
19.36

;

SD
=
1.06

) completed the Simple Coping Style Questionnaire, the Eating Disorder Inventory, the Security Questionnaire, the Hospital Anxiety and Depression Scale, and a brief demographic survey. The percentage bootstrap method of deviation correction was conducted to determine the mediating effect of anxiety and sense of security on coping style and disordered eating behaviors. Results. Coping style had direct and indirect effects on disordered eating behaviors. Anxiety and sense of security were not only independent mediators in the relationship between coping style and disordered eating behaviors but also chain mediators. Conclusions. The results of the current study provide preliminary evidence that preventive interventions targeting anxiety and sense of security may be feasible for young women who develop disordered eating behaviors due to stress in their lives.
Therapeutic Potential of Chemically Modified, Synthetic, Triplex Peptide Nucleic Acid–Based Oncomir Inhibitors for Cancer Therapy
Authors: Dhuri Karishma , Gaddam Ravinder Reddy , Vikram Ajit , Slack Frank J. , Bahal Raman 
Published: September 2021

AbstractmiRNA-155 (miR-155) is overexpressed in various types of lymphomas and leukemias, suggesting that targeting miR-155 could be a potential platform for the development of precision medicine. Here, we tested the anticancer activity of novel, chemically modified, triplex peptide nucleic acid (PNA)–based antimiRs compared with the current state-of-the-art conventional full-length antimiRs. Next-generation modified PNAs that bound miR-155 by Watson–Crick and Hoogsteen domains possessed superior therapeutic efficacy in vivo and ex vivo compared with conventional full-length anti–miR-155. The efficacy of anti–miR-155 targeting in multiple lymphoma cell lines was comprehensively corroborated by gene expression, Western blot analysis, and cell viability–based functional studies. Finally, preclinical testing in vivo in xenograft mouse models containing lymphoma cell lines demonstrated that treatment with the miR-155-targeting next-generation antimiR resulted in a significant decrease in miR-155 expression, followed by reduced tumor growth. These findings support the effective therapeutic application of chemically modified triplex PNAs to target miR-155 to treat lymphoma. Overall, the present proof-of-concept study further implicates the potential for next-generation triplex gamma PNAs to target other miRNAs for treating cancer.Significance:This study demonstrates the utility of novel oncomiR inhibitors as cancer therapeutics, providing a new approach for targeting miRNAs and other noncoding RNAs.
Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures
Authors: Katzke Verena A. , Le Cornet Charlotte , Mahfouz Rayaan , Brauer Bianca , Johnson Theron , Canzian Federico , Rebours Vinciane , Boutron-Ruault Marie-Christine , Severi Gianluca , Schulze Matthias B. , Olsen Anja , Tjønneland Anne , Overvad Kim , Crous-Bou Marta , Molina-Montes Esther , Amiano Pilar , Huerta José María , Ardanaz Eva , Perez-Cornago Aurora , Masala Giovanna , Pala Valeria , Tumino Rosario , Sacerdote Carlotta , Panico Salvatore , Bueno-de-Mesquita Bas , Vermeulen Roel , Sund Malin , Franklin Oskar , Christakoudi Sofia , Dossus Laure , Weiderpass Elisabete , Olek Sven , Kaaks Rudolf 
Published: September 2021

Abstract

Background:
Evidence is accumulating that immune cells play a prominent role in pancreatic cancer etiology but prospective investigations are missing.

Methods:
We conducted a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sublineages: total CD3+, CD8+, CD4+, and FOXP3+ regulatory T cells (Tregs) relative to nucleated cells, (white blood cells) were measured by qRT-PCR. ORs with 95% confidence intervals were estimated using logistic regressions, modeling relative counts of immune cells on a continuous scale.

Results:
Neither relative counts of immune cell types taken individually, nor mutually adjusted for each other were associated with pancreatic cancer risks. However, in subgroup analyses by strata of lag-time, higher relative counts of Tregs and lower relative counts of CD8+ were significantly associated with an increased pancreatic cancer risks in participants diagnosed within the first 5 years of follow-up.

Conclusions:
These results might reflect reverse causation, due to higher relative counts of Tregs and lower counts of CD8+ cells among individuals with more advanced stages of latent pancreatic cancer, who are closer to the point of developing clinical manifest disease.

Impact:
We have shown, for the first time, that increased relative counts of regulatory T cells and lower relative counts of CD8+, cytotoxic T cells may be associated with pancreatic cancer risk or relatively late-stage tumor development.
See related commentary by Michaud and Kelsey, p. 2176
Is Hodgkin Lymphoma Associated with Hepatitis B and C Viruses? A Systematic Review and Meta-analysis
Authors: Mullen Callum J.R. , Volesky Karena D. , Greenwald Zoë R. , El-Zein Mariam , Franco Eduardo L. 
Published: September 2021

Abstract

Background:
Apart from the Epstein–Barr virus (EBV), the etiology of the hematologic malignancy Hodgkin lymphoma (HL) is not well defined. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are associated with some lymphoproliferative diseases with similarities to HL.

Methods:
We performed a systematic review and meta-analysis, by searching Embase, MEDLINE, and Web of Science databases on March 9, 2021, for studies reporting a measure of association for HBV and HL or HCV and HL. We calculated pooled relative risks (RR) and their 95% confidence intervals (CI).

Results:
Pooling nine HBV studies with 1,762 HL cases yielded an RR of 1.39 (95% CI, 1.00–1.94) and pooling 15 HCV studies with 4,837 HL cases resulted in an RR of 1.09 (95% CI, 0.88–1.35). Meta-analyzing by study design, hepatitis detection method, and region revealed two subgroups with statistically significant associations—HCV studies that used hospital-based controls and/or were conducted in the West Pacific. No included study assessed age or EBV tumor status in relation to HL.

Conclusions:
Although we did not find an association between HBV or HCV and HL, research assessing the impact of age and EBV tumor status was lacking.

Impact:
The effect of HBV or HCV infection in the development of HL remains unclear.
Precision Dosing of Targeted Therapies Is Ready for Prime Time
Authors: Groenland Stefanie L. , Verheijen Remy B. , Joerger Markus , Mathijssen Ron H.J. , Sparreboom Alex , Beijnen Jos H. , Beumer Jan H. , Steeghs Neeltje , Huitema Alwin D.R. 
Published: September 2021

Abstract
Fixed dosing of oral targeted therapies is inadequate in the era of precision medicine. Personalized dosing, based on pharmacokinetic (PK) exposure, known as therapeutic drug monitoring (TDM), is rational and supported by increasing evidence. The purpose of this perspective is to discuss whether randomized studies are needed to confirm the clinical value of precision dosing in oncology. PK-based dose adjustments are routinely made for many drugs and are recommended by health authorities, for example, for patients with renal impairment or for drug–drug interaction management strategies. Personalized dosing simply extrapolates this paradigm from selected patient populations to each individual patient with suboptimal exposure, irrespective of the underlying cause. If it has been demonstrated that exposure is related to a relevant clinical outcome, such as efficacy or toxicity, and that exposure can be optimized by PK-guided dosing, it could be logically assumed that PK-guided dosing would result in better treatment outcomes without the need for randomized confirmatory trials. We propose a path forward to demonstrate the clinical relevance of individualized dosing of molecularly-targeted anticancer drugs.
Whole-body PET Imaging of T-cell Response to Glioblastoma
Authors: Nobashi Tomomi W. , Mayer Aaron T. , Xiao Zunyu , Chan Carmel T. , Chaney Aisling M. , James Michelle L. , Gambhir Sanjiv S. 
Published: September 2021

AbstractPurpose:Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in patients with glioblastoma treated with immunotherapy. Here, the utility of OX40, a costimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a PET imaging biomarker to quantify and track response to immunotherapy.Experimental Design:A subcutaneous vaccination approach of CpG oligodeoxynucleotide, OX40 mAb, and tumor lysate at a remote site in a murine orthotopic glioma model was developed to induce activation of T cells distantly while monitoring their distribution in stimulated lymphoid organs with respect to observed therapeutic effects. To detect OX40-positive T cells, we utilized our in-house–developed 89Zr-DFO-OX40 mAb and in vivo PET/CT imaging.Results:ImmunoPET with 89Zr-DFO-OX40 mAb revealed strong OX40-positive responses with high specificity, not only in the nearest lymph node from vaccinated area (mean, 20.8%ID/cc) but also in the spleen (16.7%ID/cc) and the tumor draining lymph node (11.4%ID/cc). When the tumor was small (&lt;106 p/sec/cm2/sr in bioluminescence imaging), a high number of responders and percentage shrinkage in tumor signal was indicated after only a single cycle of vaccination.Conclusions:The results highlight the promise of clinically translating cancer vaccination as a potential glioma therapy, as well as the benefits of monitoring efficacy of these treatments using immunoPET imaging of T-cell activation.