bluuebunny/crossref_metadata_2025_split huggingface dataset:
A design-led framework for engaged research: Using a design approach to understand and place the public at the core of health and social care
Authors: Galvin Mary , Kennan Avril , Shé Éidín Ní 
Published: August 2021

Abstract
This paper offers a multi-perspective approach on the role of engaged research in health and social care. Each of the authors focuses on their individual experiences of this domain, from the perspective of an academic partner of the Health Research Board’s PPI Ignite programme, a CEO of an umbrella organisation for health research charities and a researcher in design innovation, focusing on health research. The paper outlines the values which underpin public and patient involvement, as well as examples of its application as engaged research. It details how organisations like Health Research Charities Ireland support and enable engaged research within health and social research and policy. This paper offers a framework for facilitating dialogue and response across all stakeholders in the engaged research process, illustrating the importance of engaged research and how we can further our understanding and application of it within health and social care policy by adopting a design-led approach. We argue that a design-led approach can both facilitate engaged research as well as support policymakers in the design of new policies and practices.
From the community handywomen to frontline heroes: Charting a century of Irish nursing and midwifery regulation
Authors: Murphy Denis , Gilligan Kim , Watson Derek 
Published: August 2021

Abstract
This paper argues that professional regulatory frameworks are shaped by sociocultural factors and prevailing ideologies that stem from society’s interactions with and expectations of the regulated professions. Taking a century of Irish nursing and midwifery regulation as a case reflection, the paper highlights five regulatory pivot points to provide a historical narrative of how adopting a sociocultural perspective can enlighten our understanding of the current regulatory form. A form that in early twenty-first-century Ireland resulted in the establishment of a professionally contentious, non-professional (lay) majority on the regulatory board for these frontline professions. The paper concludes by suggesting that when viewed through a sociocultural lens, regulatory change is to be expected. As prevailing ideologies change, power, influence and cultures alter to support and reinforce the new ideology. Professional regulation thereby becomes reflective of society’s views on professionalism and professional identity, drawing on society’s historical experiences of the professions.
Employment of Students From Pharmaceutical Specialties – A Pilot, Retrospective-Prospective, Longitudinal, Questionnaire Survey in Two Centers in Bulgaria
Authors: Gergov K. , Burgazliev H. , Hristov E. , Shopov G. , Ognyanov S. 
Published: August 2021

Abstract

Aim
To investigate the employment, the desire to work, the work habits and preferences of the students from the pharmaceutical specialties in Bulgaria. Secondary objectives: To analyze the possibilities for employment, to assess its lawfulness, to analyze existing vicious practices, to establish the main problem in fitting together the academic learning process and the work activity.

Materials and methods
This was a pilot, retrospective-prospective, longitudinal survey in two centers. We developed a survey questionnaire containing 28 questions of both the open-ended and closed-ended types. The data collection was done using the “Direct individual poll” method. he target group consisted of 165 students from pharmaceutical specialties – pharmacy students from Faculty of Chemistry and Pharmacy, Sofia University “Sv. Kliment Ohridski”, and Bachelor-pharmacists from the Medical College, University “Prof. Dr. Assen Zlatarov”, Bourgas. The data were processed with the SPSS software.

Results
The results are presented in two parts: the first part refers to Bachelors of Pharmacy, and the second – to Masters of Pharmacy. In their majority, the pharmacy students work during their academic studies – 86.4%. The main stimulus for starting work is of financial origin. Of all students working, 56.8% were hired on an employment contract, while up to one-third worked without any contract at all. In the case of assistant pharmacists 4 45.3% of the respondents worked, and the majority of the respondents did it for financial reasons (66.7%). 86.2% had a signed employment contract, but 67.9% were insured on the basis of the minimum salary. Most commonly the students were working in the field of their future specialty in the pharmacy network.

Conclusion
The students indicated difficulties in the process of combining their work activity and their studies, a negative attitude to the legal framework and easily discernible negative attitude towards the main field of fulfillment also by the Masters of Pharmacy – working in a pharmacy.
A Rare Case of Stargardt’s Disease
Authors: Mermeklieva I. , Kamenarova K. 
Published: August 2021

Abstract

Objective
To describe a clinical case of rare eye diseases – Stargardt’s disease. Material and methods: A detailed clinical examination, fundus autofluorescence, optical coherence tomography and electrophysiological studies were performed. The clinical diagnosis was also genetically confirmed.

Results
A classic Stargardt’s disease phenotype was found in a 10-year old boy with decreased visual acuity, atrophy of the photoreceptors and retinal pigment epithelium layers in the macula, plus hypoautofluorescence in the fovea. In full-field ERG there was no diffuse cone involvement. Multifocal ERG demonstrated a lower cone activity in the area of the central macula in both eyes, which is characteristic for hereditary maculopathies and differentiates them from cone-rod dystrophies, in which generalized damage of the photoreceptors in the retina may be observed. The genetic studies identified two missense mutations: c.3113C> T (p.Ala1038Val) and c.1622T> C (p.Leu541Pro) in a cis-position and a missense mutation c.2588G> C (p.Gly863Ala) in the other allele of ABCA4 gene. The two pathogenic variants c.3113C> T and c.1622T> C formed a complex allele p. [A1038V; L541P], which was found in the genome of the asymptomatic mother. The other mutation c.2588G> C affects a highly conserved amino acid from the ABCA4 protein (p.Gly863Ala) and was inherited from the patient’s clinically healthy father, who was a heterozygous carrier.

Conclusion
The comprehensive clinical, electrophysiological and genetic testing of patients with rare hereditary retinal dystrophies is essential for the correct diagnosis and the choice of therapeutic behavior.
Development and Evaluation of Personal Urban Concept Vehicle Powered by a Hydrogen Fuel Cell
Authors: Beloev Ivan 
Published: August 2021

Abstract
To reduce the levels of harmful emissions and to minimize the noise pollution, many leading countries have started pilot projects and initiatives for gradual transition to electrical vehicles or vehicles powered by alternative fuel sources, including natural gas, hydrogen, propane, biofuels, and methanol. Parallel to this, many automotive companies are also exploring and using every possibility to introduce newer manufacturing technologies and materials in the vehicle development and construction processes. The results of these efforts are vehicles that are lighter and have lower fuel consumption, but at the same time are capable to provide the industry approved levels of comfort, reliability, and protection to the passengers. One of the many drivers for the abovementioned evolution of the automotive industry are the numerous events and races, where teams from different countries and continents are competing for dominance. The focus of this paper is to present the processes for design, development and evaluation of a hydrogen fuel cell powered racing vehicle, which was developed at the “Angel Kanchev” University of Ruse in Bulgaria. The paper presents results from simulated and real on-track experiments with the vehicle prototype. Emulations and analysis on the possibilities to improve the vehicle performance, as well as to increase the effectiveness of the vehicle power supply system, using a system for regenerative braking, are also provided in the last section of the paper.
Impacts of Automatic and Parallel Driving Systems on the Productivity of Machine-Tractor Units in the Northern Region of the Republic of Kazachstan
Authors: Polishchuk Yurij Vladimirovich , Astafyev Vladimir Leonidovich , Derepaskin Alexey Ivanovich , Kostyuchenkov Nikolay Vladimirovich , Laptev Nikolay Vladimirovich , Komarov Artem Pavlovich 
Published: August 2021

Abstract
Precision farming systems are being intensively introduced into the agricultural production of the Republic of Kazakhstan. According to developers and dealers, precision farming can reduce the cost of fertilizers, seeds, PPA, fuel and lubricants by 20% on average. At the same time, the efficiency possibilities resulting from the utilization of precision farming systems under certain conditions have not been fully studied. The aim of this work was to assess the influence of parallel and automatic driving systems on the technical, operational and economic indicators of units for sowing, chemical processing, harvesting, and autumn deep tillage using comparative tests in the northern region of the Republic of Kazakhstan. For these purposes, comparative tests were conducted for a seeder for sowing wheat; self-propelled sprayer for chemical weeding of wheat and flax; combine harvester for harvesting wheat; and unit for deep, subsurface tillage in Northern Kazakhstan. The comparative tests determined the impacts of GPS navigation systems, automatic and parallel control systems, and seeding control systems on agricultural, energy, operational, technological and economic performance of units.
Evaluation of soil properties in variously aged Scots pine plantations established on sandy soil
Authors: Šurda Peter , Lichner Ľubomír , Kollár Jozef , Zvala Anton , Igaz Dušan 
Published: August 2021

Abstract
Pines are widely planted for sand dune stabilization and their cultivation results in the changes in physical, chemical, hydro-physical and water repellency properties. Soil properties were evaluated at three Scots pine plantations (PF1, PF2 and PF3) close to Studienka village, Borská nížina lowland (southwestern Slovakia) during hot and dry summer period. The PF1 site is a newly established plantation, the PF2 site is about 30 years old plantation, and the PF3 site is about 100 years old plantation. Here, we estimated the differences in pH, soil organic carbon content, Cox, particle size distribution, PSD, saturated, ks, and unsaturated, k(–2 cm), hydraulic conductivity, water, Sw
, and ethanol, Se
, sorptivity, water drop penetration time, WDPT, and repellency index, RI. It was found that Cox varies most significantly with plantation age, and relative differences in PSD and pH were lower than the relative difference in Cox. The PF3 site differs the most from the other two, especially in Cox and in the content of sand fraction. It can be attributed to the older age of the plantation, which represents a more advanced stage of succession accompanied by an accumulation of soil organic matter. Relationships between Cox, k(–2 cm), RI, and WDPT and pine forest age were described by appropriate mathematical models. We found a similarity between k(–2 cm) and RI relationships vs. pine forest age (exponential models), and between Cox and WDPT relationships vs. pine forest age (first and second-order polynomial models). The latter similarity can be supported by the fact that soil water repellency is induced by the hydrophobic and amphiphilic components of soil organic matter.
Local scour around a bridge pier under ice-jammed flow condition – an experimental study
Authors: Wang Jun , Hou Zhixing , Sun Hongjian , Fang Bihe , Sui Jueyi , Karney Bryan 
Published: August 2021

Abstract
The appearance of an ice jam in a river crucially distorts local hydrodynamic conditions including water level, flow velocity, riverbed form and local scour processes. Laboratory experiments are used for the first time here to study ice-induced scour processes near a bridge pier. Results show that with an ice sheet cover the scour hole depth around a bridge is increased by about 10% compared to under equivalent open flow conditions. More dramatically, ice-jammed flows induce both greater scour depths and scour variability, with the maximum scour depth under an ice-jammed flow as much as 200% greater than under equivalent open flow conditions. Under an ice-jammed condition, both the maximum depth and length of scour holes around a bridge pier increase with the flow velocity while the maximum scour hole depth increases with ice-jam thickness. Also, quite naturally, the height of the resulting deposition dune downstream of a scour hole responds to flow velocity and ice jam thickness. Using the laboratory data under ice-jammed conditions, predictive relationships are derived between the flow’s Froude number and both the dimensionless maximum scour depth and the dimensionless maximum scour length.
Relative role of sediment entrainments on log-law parameters of longitudinal velocity distributions in mobile bed flows
Authors: Malakar Pritam , Das Ratul 
Published: August 2021

Abstract
In alluvial channel, the non-cohesive bed particles are frequently accelerated by the flows and there has been an inconclusive debate on the deviations of logarithmic law parameters that demonstrate the velocity distributions in flows. Present study aims to elucidate the current knowledge of overwhelming theoretical and experimental evidences in this regard within the scope of near-bed turbulent flow characteristics. The study was conducted in two folds collecting instantaneous velocity of flow over a rigid sand bed under clear water flow conditions and compared to those over mobile sand beds under equilibrium bed-load. Results corroborated additional support to confirm the upward shifting of zero-velocity level in mobile bed flows. Most importantly, the conventional value of von Kármán coefficient significantly deviates in mobile bed flows compared to those in rigid sand bed. Also, the frictional velocity obtained from the bed slope consistently differs to those obtained from the Reynolds shear stress (RSS) distributions owing to transfer of stress aliquot to the bed particles. The mechanism is well demonstrated with the energy-momentum transfer within the framework of energy budget concept which shows near-bed negative pressure energy diffusion rates with increasing turbulence production in mobile bed flows.
Integral transforms for three-dimensional pumping in confined, leaky, and unconfined aquifers
Authors: Silva Elizeu Melo da , Quaresma João N. N. , Macêdo Emanuel N. , Cotta Renato M. 
Published: August 2021

Abstract
Analytical or hybrid numerical-analytical solutions based on the Generalized Integral Transform Technique (GITT) are obtained for the transient three-dimensional pumping problem of aquifers with a fully penetrating vertical well between two parallel streams. The problem formulation for confined and leaky aquifers allows for achieving exact analytical solutions through integral transforms, while the unconfined aquifer case introduces a fourth kind boundary condition which leads to a coupled transformed head ordinary differential system, that can be solved either analytically or numerically. A convergence analysis is performed to illustrate the consistency of the numerical results achieved for the head distribution, as well as for the related pumping rates. Results are obtained for selected cases and comparisons with literature results are performed. A solution verification confirms the agreement of the integral transform solutions with available simulations and provides additional confidence for the analysis of a few physical parameters that influence the hydrological behavior.
Experimental Study of the Chaotic Jerk Circuit Application for Chaos Shift Keying
Authors: Capligins F. , Litvinenko A. , Aboltins A. , Austrums E. , Rusins A. , Pikulins D. 
Published: August 2021

Abstract
The paper presents a study of the chaotic jerk circuit (CJC) employment capabilities for digital communications. The concept of coherent chaos shift keying (CSK) communication system with controlled error feedback chaotic synchronization is proposed for a specific CJC in two modifications. The stability of chaotic synchronization between the two CJCs was evaluated in terms of voltage drop at the input of the slave circuit and the impact of channel noise using simulations and experimental studies.
Methods of Fuzzy Set in Simulation for Predicting Unobserved States of the Ecological and Geoengineering Systems
Authors: Yeremeyev I. , Dychko A. , Kyselov V. , Remez N. , Kraychuk S. , Ostapchuk N. 
Published: August 2021

Abstract
The present paper provides the ways of implementing methods of fuzzy set approach, which contributes to an increase in the accuracy, efficiency and functional flexibility of the complex control and recognition monitoring systems for the environmental and geoengineering system simulation. They are based on data mining methods and may be implemented with the help of intellectual technologies, including the combination of model pluralism, membership functions, methods of nearest neighbour, results of fractal and chaos theories, methods of ensuring robustness and retrospective analysis of the decision tree for success in decision making in similar situations.
It is proposed to use the model pluralism to explain a particular information process, which uses a number of adequate models, describing the behavior of objects in the case where each of the model reflects its behavior objectively, but under different circumstances, which are difficult to consider a priori in real time when choosing an adequate model. It is shown that the method of the nearest neighbour should be used if it necessary to identify causal relationships and predict further development of the environmental safety events.
Are radiation-induced cavernomas clinically relevant findings? Results from long-term follow-up with brain magnetic resonance imaging of childhood cancer survivors
Authors: Becker Lucas , Gebauer Judith , Küchler Jan , Staackmann Christian , Schacht Hannes , Lauten Melchior , Jensen-Kondering Ulf , Schramm Peter , Langer Thorsten , Neumann Alexander 
Published: August 2021

Abstract

Introduction
Radiation-induced cavernomas (RIC) after cranial radiotherapy have an unknown risk of hemorrhage. Zabramski magnetic resonance imaging (MRI) classification is touted as being able to indicate non-radiation-induced cavernomas hemorrhage risk. The aim of our study was to assess the hemorrhage risk of RIC during long-term follow-up of childhood cancer survivors based on brain MRI examinations.

Patients and methods
We analyzed retrospectively long-term follow-up data of 36 childhood cancer survivors after initial diagnosis with acute leukemia (n = 18) or brain tumor (n = 18), all treated with cranial radiotherapy. Detected RIC in long-term follow-up brain MRI (1.5 or 3 Tesla) were classified following the Zabramski MRI classification and were categorized into “high” (Zabramski type I, II or V) or “low” (type III or IV) risk of hemorrhage.

Results
18 patients (50%) showed RIC with a significant relation to the original tumor entity (p = 0.023) and the cumulative radiation dose to the brain (p = 0.016): all 9 childhood cancer survivors diagnosed with medulloblastoma developed RIC. We classified RIC in only 3/36 childhood cancer survivors (8%) (1 patient with acute lymphoblastic leukemia [Zabramski type II] and 2 patients with medulloblastoma [type I and type II]) as high risk for hemorrhage, the remaining RIC were classified as Zabramski type IV with low risk for hemorrhage. None of the childhood cancer survivors with RIC showed symptomatic hemorrhages.

Conclusions
RIC are common late effects in childhood cancer survivors treated with cranial radiotherapy affecting half of these patients. However, only a few RIC (occurring in 8% of all reviewed childhood cancer survivors) were classified as high risk for hemorrhage and none of the childhood cancer survivors with RIC developed symptomatic hemorrhages. Thus, we conclude that RIC are low-risk findings in brain MRI and the course is mainly benign.
Morphological features of breast cancer circulating tumor cells in blood after physical and biological type of isolation
Authors: Jesenko Tanja , Modic Ziva , Kuhar Cvetka Grasic , Cemazar Maja , Matkovic Urska , Miceska Simona , Varl Jerneja , Kuhar Anamarija , Kloboves-Prevodnik Veronika 
Published: August 2021

Abstract

Background
Circulating tumor cells (CTCs) have become an important biomarker in breast cancer. Different isolation tech-niques based on their biological or physical features were established. Currently, the most widely used methods for visualization after their separation are based on immunofluorescent staining, which does not provide the information on the morphology.

Materials and methods
The aim of this study was to evaluate how two different separation techniques affect cell morphology and to analyse cell morphology with techniques used in routine cytopathological laboratory. A direct side-by-side comparison of physical (Parsortix®) and biological (MACS®) separation technique was performed.

Results
In the preclinical setting, both isolation techniques retained the viability and antigenic characteristics of MCF7 breast cancer cells. Some signs of degeneration such as cell swelling, cytoplasmic blebs, villous projections and vacuolization were observed. In metastatic breast cancer patient cohort, morphological features of isolated CTCs were dependent on the separation technique. After physical separation, CTCs with preserved cell morphology were detected. After biological separation the majority of the isolated CTCs were so degenerated that their identity was difficult to confirm.

Conclusions
Taken together, physical separation is a suitable technique for detection of CTCs with preserved cell morphology for the use in a routine cytopathological laboratory.
Characteristic parameters of soil failure criteria for plane strain conditions – experimental and semi-theoretical study
Authors: Sławińska-Budzich Justyna 
Published: August 2021

Abstract
The paper concerns the characteristic parameters of the selected isotropic failure criteria, i.e. Mohr–Coulomb, Drucker–Prager, Matsuoka–Nakai and Lade–Duncan. The parameters are determined directly from the failure criteria and stress measurements or by semi-theoretical approach, assuming that the soil obeys the associated flow rule and using the plane strain condition. In the latter case, the parameters can be expressed as functions of the plane strain internal friction angle, which is determined from measurements. The principal stress tensor components, corresponding to the soil peak strength and necessary to obtain the failure criteria parameters, are measured in a series of true triaxial, plane strain tests, on coarse Skarpa sand samples of different initial relative density, subjected to various confining pressures.