bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes, perceptions and behaviours regarding meat consumption in Germany: results of the NEMONIT study
Authors: Koch Franziska , Krems Carolin , Heuer Thorsten , Claupein Erika 
Published: May 2021

Abstract
Meat consumption in Germany is presently higher than recommended for a healthy and sustainable nutrition. Therefore, the aim of the present study was to explore German consumers’ attitudes, perceptions and behaviours regarding meat consumption based on data from 1807 participants (20–80 years) of the NEMONIT study (2012/13). Data were obtained using computer-assisted telephone interviews including 24-h recalls and a food-frequency questionnaire (FFQ). The majority (97 %) of the participants were meat consumers and most of them stated that an ideal meal should contain meat. Their main motives for meat consumption were good taste, usual habit and the perception of meat as a healthy and satiable food. The stated meat consumption frequency was higher than the ‘desired’ consumption frequency, answered in a FFQ. Most participants would agree with two meat meals per week, but only 17 % assumed that the German population would agree. Therefore, framework conditions do not motivate people enough to reduce their meat consumption. Options for action which can be implemented in daily routine are needed. Meat is still a largely appreciated food in Germany, but the results indicate a potential for behavioural changes which must be exploited urgently to reduce meat consumption to a healthy and sustainable level.
Marginal farmers carry the burden of damage caused by Asian elephantsElephas maximusin Bardiya National Park, Nepal
Authors: Prins Herbert H.T. , Liefting Yorick , de Jong Joost F. 
Published: May 2021

AbstractIn areas where farmland borders protected areas, wildlife may be attracted to crops and cause substantial financial damage for farmers. Elephants, in particular, can destroy a year's harvest in a single night, and can also cause damage to buildings and other farm structures. Few studies have examined whether damage caused by wild elephants increases social inequalities in farmer communities. We interviewed settlement leaders and subsistence rice farmers living in the buffer zone of Bardiya National Park, Nepal, to examine (1) the variation and spatial distribution of wealth within the farmer community, (2) the severity and spatio-temporal distribution of damage inflicted by Asian elephantsElephas maximus, and (3) the willingness to insure against such damage. We investigated whether particular societal strata are disproportionally affected by negative interactions with elephants. We found that farmers near the boundary between agricultural and wilderness areas were significantly poorer and had smaller landholdings than those further into the cultivated lands. Concomitantly, damage to crops and houses was more frequent nearer the wilderness–agriculture boundary than further away from it. Hence, in the buffer zone of Bardiya National Park, farmers near the wilderness–cultivation boundary, with small landholdings, had a relatively higher cost of elephant damage, yet were less willing to pay for an insurance scheme. We infer that in areas where both social inequality and damage caused by wildlife are spatially structured, conservation success may cause economic hardship for the local community, particularly for the poorer class. We discuss causes of the current lack of communal mitigation measures against the damage caused by elephants in the Park, and potential solutions.
Relationship between mental health diagnoses and COVID-19 test positivity, hospitalization, and mortality in Southeast Wisconsin
Authors: Egede Christine , Dawson Aprill Z. , Walker Rebekah J. , Garacci Emma , Campbell Jennifer A. , Egede Leonard E. 
Published: May 2021

AbstractBackgroundThere is a paucity of literature on the relationship between pre-existing mental health conditions and coronavirus disease-2019 (COVID-19) outcomes. The aim was to examine the association between pre-existing mental health diagnosis and COVID-19 outcomes (positive screen, hospitalization, mortality).MethodsElectronic medical record data for 30 976 adults tested for COVID-19 between March 2020 and 10th July 2020 was analyzed. COVID-19 outcomes included positive screen, hospitalization among screened positive, and mortality among screened positive and hospitalized. Primary independent variable, mental health disorders, was based on ICD-10 codes categorized as bipolar, internalizing, externalizing, and psychoses. Descriptive statistics were calculated, unadjusted and adjusted logistic regression and Cox proportional hazard models were used to investigate the relationship between each mental health disorder and COVID-19 outcomes.ResultsAdults with externalizing (odds ratio (OR) 0.67, 95%CI 0.57–0.79) and internalizing disorders (OR 0.78, 95% CI 0.70–0.88) had lower odds of having a positive COVID-19 test in fully adjusted models. Adults with bipolar disorder had significantly higher odds of hospitalization in fully adjusted models (OR 4.27, 95% CI 2.06–8.86), and odds of hospitalization were significantly higher among those with externalizing disorders after adjusting for demographics (OR 1.71, 95% CI 1.23–2.38). Mortality was significantly higher in the fully adjusted model for patients with bipolar disorder (hazard ratio 2.67, 95% CI 1.07–6.67).ConclusionsAdults with mental health disorders, while less likely to test positive for COVID-19, were more likely to be hospitalized and to die in the hospital. Study results suggest the importance of developing interventions that incorporate elements designed to address smoking cessation, nutrition and physical activity counseling and other needs specific to this population to improve COVID-19 outcomes.
Secession, self-determination and territorial disagreements: Sovereignty claims in the contemporary South Pacific
Authors: Heathcote Sarah 
Published: May 2021

AbstractThis article maps the legally varied sovereignty claims in the contemporary South Pacific; whether secessionist, self-determination based, or consisting of territorial disputes or lesser disagreements. The analysis reveals that Pacific practice in this domain is consistent with general international law; that despite any fractures at the domestic level, relations between the states and territories of the region is peaceful, that their shared values have instead given rise to innovative solutions to legal problems concerning territory, either through the leveraging of regional institutions – so vital to the region’s identity – to pursue claims against metropolitan powers, or through innovative arrangements to alleviate territorial problems left by colonial powers. Indeed, the region is replete with innovative legal solutions based on shared values and peaceful international relations. As such, Pacific practice and engagement with international law can provide a blueprint for others around the globe.
Spanning trees in random regular uniform hypergraphs
Authors: Greenhill Catherine , Isaev Mikhail , Liang Gary 
Published: May 2021

AbstractLet $${{\mathcal G}_{n,r,s}}$$ denote a uniformly random r-regular s-uniform hypergraph on the vertex set {1, 2, … , n}. We establish a threshold result for the existence of a spanning tree in $${{\mathcal G}_{n,r,s}}$$, restricting to n satisfying the necessary divisibility conditions. Specifically, we show that when s ≥ 5, there is a positive constant ρ(s) such that for any r ≥ 2, the probability that $${{\mathcal G}_{n,r,s}}$$ contains a spanning tree tends to 1 if r > ρ(s), and otherwise this probability tends to zero. The threshold value ρ(s) grows exponentially with s. As $${{\mathcal G}_{n,r,s}}$$ is connected with probability that tends to 1, this implies that when r ≤ ρ(s), most r-regular s-uniform hypergraphs are connected but have no spanning tree. When s = 3, 4 we prove that $${{\mathcal G}_{n,r,s}}$$ contains a spanning tree with probability that tends to 1, for any r ≥ 2. Our proof also provides the asymptotic distribution of the number of spanning trees in $${{\mathcal G}_{n,r,s}}$$ for all fixed integers r, s ≥ 2. Previously, this asymptotic distribution was only known in the trivial case of 2-regular graphs, or for cubic graphs.
Migrant Middle Eastern women with gestational diabetes seven years after delivery – positive long-term development of beliefs about health and illness shown in follow-up interviews
Authors: Hjelm Katarina , Bard Karin , Apelqvist Jan 
Published: May 2021

Abstract

Aim:
No previous studies have been found focusing on the long-term development of beliefs about health, illness and healthcare in migrant women with gestational diabetes mellitus (GDM). The aim of this study was to explore this and the influence on health-related behaviour (i.e. self-care and care seeking) in migrant women from the Middle East living in Sweden seven years after delivery.

Background:
GDM is increasing, particularly in migrant women. The risk of adverse outcomes of GDM for health can be improved by interventions reducing blood glucose and lifestyle modifications which medicalise the woman’s pregnancy due to intensive follow-up and demanding self-care. The reactions might have an enduring impact on the women’s long-term psychological and physical health and adoption of preventive health behaviours.

Method:
Qualitative exploratory study. Semi-structured follow-up interviews 7 years after delivery with women previously interviewed in gestational weeks 34–38 and 3 and 14 months after delivery. Data analysed with qualitative content analysis.

Findings:
Health meant freedom from illness, feeling well and living long to be able to care for the children. The present situation was described either positively, changing to a healthier lifestyle, or negatively, with worries about being affected by type 2 diabetes. Beliefs changed among the majority of women, leading to a healthier lifestyle, and they looked positively back at the time when diagnosed and their reactions to it. With few exceptions, they were confident of being aware of future health risks and felt responsible for their own and their children’s health/lifestyle. None except those diagnosed with type 2 diabetes had been in contact with healthcare since the last follow-up a year after delivery. Yet, they still would like and need a healthcare model delivering more information, particularly on developing a healthy lifestyle for children, and with regular check-ups also after the first year after delivery.
A tuneable rat-race coupler for full duplex communications
Authors: Watkins G. T. 
Published: May 2021

AbstractFull duplex (FD) could potentially double wireless communications capacity by allowing simultaneous transmission and reception on the same frequency channel. A single antenna architecture is proposed here based on a modified rat-race coupler to couple the transmit and receive paths to the antenna while providing a degree of isolation. To allow the self-interference cancellation (SiC) to be maximized, the rat-race coupler was made tuneable. This compensated for both the limited isolation of the rat race and self-interference caused by antenna mismatch. Tuneable operation was achieved by removing the fourth port of the rat race and inserting a variable attenuator and variable phase shifter into the loop. In simulation with a 50 Ω load on the antenna port, better than −65 dB narrowband SiC was achieved over the whole 2.45 GHz industrial, scientific and medical (ISM) band. Inserting the S-parameters of a commercially available sleeve dipole antenna into the simulation, better than −57 dB narrowband SiC could be tuned over the whole band. Practically, better than −58 dB narrowband tuneable SiC was achieved with a practical antenna. When excited with a 20 MHz Wi-Fi signal, −42 dB average SiC could be achieved with the antenna.
Year‐2020 Global Distribution and Pathways of Reservoir Methane and Carbon Dioxide Emissions According to the Greenhouse Gas From Reservoirs (G‐res) Model
Authors: Harrison John A. , Prairie Yves T. , Mercier‐Blais Sara , Soued Cynthia 
Published: May 2021

AbstractCollectively, reservoirs constitute a significant global source of C‐based greenhouse gases (GHGs). Yet, global estimates of reservoir carbon dioxide (CO2) and methane (CH4) emissions remain uncertain, varying more than four‐fold in recent analyses. Here we present results from a global application of the Greenhouse Gas from Reservoirs (G‐res) model wherein we estimate per‐area and per‐reservoir CO2 and CH4 fluxes, by specific flux pathway and in a spatially and temporally explicit manner, as a function of reservoir characteristics. We show: (a) CH4 fluxes via degassing and ebullition are much larger than previously recognized and diffusive CH4 fluxes are lower than previously estimated, while CO2 emissions are similar to those reported in past work; (b) per‐area reservoir GHG fluxes are >29% higher than suggested by previous studies, due in large part to our novel inclusion of the degassing flux in our global estimate; (c) CO2 flux is the dominant emissions pathway in boreal regions and CH4 degassing and ebullition are dominant in tropical and subtropical regions, with the highest overall reservoir GHG fluxes in the tropics and subtropics; and (d) reservoir GHG fluxes are quite sensitive to input parameters that are both poorly constrained and likely to be strongly influenced by climate change in coming decades (parameters such as temperature and littoral area, where the latter may be expanded by deepening thermoclines expected to accompany warming surface waters). Together these results highlight a critical need to both better understand climate‐related drivers of GHG emission and to better quantify GHG emissions via CH4 ebullition and degassing.
Time Dependent Flow of Atlantic Water on the Continental Slope of the Beaufort Sea Based on Moorings
Authors: Li Jianqiang , Lin Peigen , Pickart Robert S. , Yang Xiao‐Yi 
Published: May 2021

AbstractThe flow and transformation of warm, salty Atlantic‐origin water (AW) in the Arctic Ocean plays an important role in the global overturning circulation that helps regulate Earth's climate. The heat that it transports also impacts ice melt in different parts of the Arctic. This study uses data from a mooring array deployed across the shelf/slope of the Alaskan Beaufort Sea from 2002–2004 to investigate the flow of AW. A short‐lived “rebound jet” of AW on the upper continental slope regularly follows wind‐driven upwelling events. A total of 57 such events, lasting on average 3 days each, occurred over the 2 year period. As the easterly wind subsides, the rebound jet quickly spins up while the isopycnals continue to slump from their upwelled state. The strength of the jet is related to the cross‐slope isopycnal displacement, which in turn is dependent on the magnitude of the wind, in line with previous modeling. Seaward of the rebound jet, the offshore‐most mooring of the array measured the onshore branch of the AW boundary flowing eastward in the Canada Basin. However, the signature of the boundary current was only evident in the second year of the mooring timeseries. We suspect that this is due to the varying influence of the Beaufort Gyre in the two years, associated with a change in pattern of the wind stress curl that helps drive the gyre.
Convective Cloud Regimes From a Classification of Object‐Based CloudSat Observations Over Asian‐Australian Monsoon Areas
Authors: Chen Peng‐Jen , Chen Wei‐Ting , Wu Chien‐Ming , Yo Ting‐Shuo 
Published: May 2021

AbstractThe present study objectively classified the convective cloud objects detected by the space‐borne CloudSat radar over the Asian‐Australian monsoon region using the hierarchical agglomerative clustering algorithm. Based on key properties representing the morphological features and convective intensity of the systems, five distinct convective cloud regimes were derived. The unique Coastal‐Intense (CI) regime exhibits the most expansive horizontal scales (>1,000 km), high convective strength, the strongest cloud radiative effects, the highest probability of extreme rainfall, and a significant coupling with the sharp onset of the Asian summer monsoon circulation. Second, the Coastal regime illustrates smaller but also highly organized coastal convections, with the strongest convective strength. Less than 10% of the systems in the CI and Coastal regimes overlap with the tropical cyclones. The rest three regimes mark the less organized convection at various life cycle stages mainly over the land areas, with small seasonal variation in their occurrence.
Metabolic-endocrine disruption due to preterm birth impacts growth, body composition, and neonatal outcome
Authors: Möllers Lea Sophie , Yousuf Efrah I. , Hamatschek Constanze , Morrison Katherine M. , Hermanussen Michael , Fusch Christoph , Rochow Niels 
Published: May 2021

AbstractDespite optimized nutrition, preterm-born infants grow slowly and tend to over-accrete body fat. We hypothesize that the premature dissociation of the maternal–placental–fetal unit disrupts the maintenance of physiological endocrine function in the fetus, which has severe consequences for postnatal development. This review highlights the endocrine interactions of the maternal–placental–fetal unit and the early perinatal period in both preterm and term infants. We report on hormonal levels (including tissue, thyroid, adrenal, pancreatic, pituitary, and placental hormones) and nutritional supply and their impact on infant body composition. The data suggest that the premature dissociation of the maternal–placental–fetal unit leads to a clinical picture similar to panhypopituitarism. Further, we describe how the premature withdrawal of the maternal–placental unit, neonatal morbidities, and perinatal stress can cause differences in the levels of growth-promoting hormones, particularly insulin-like growth factors (IGF). In combination with the endocrine disruption that occurs following dissociation of the maternal–placental–fetal unit, the premature adaptation to the extrauterine environment leads to early and fast accretion of fat mass in an immature body. In addition, we report on interventional studies that have aimed to compensate for hormonal deficiencies in infants born preterm through IGF therapy, resulting in improved neonatal morbidity and growth.ImpactPreterm birth prematurely dissociates the maternal–placental–fetal unit and disrupts the metabolic-endocrine maintenance of the immature fetus with serious consequences for growth, body composition, and neonatal outcomes.The preterm metabolic-endocrine disruption induces symptoms resembling anterior pituitary failure (panhypopituitarism) with low levels of IGF-1, excessive postnatal fat mass accretion, poor longitudinal growth, and failure to thrive.Appropriate gestational age-adapted nutrition alone seems insufficient for the achievement of optimal growth of preterm infants.Preliminary results from interventional studies show promising effects of early IGF-1 supplementation on postnatal development and neonatal outcomes.
Molecularly profiled trials: toward a framework of actions for the “nil actionables”
Authors: Jordan Allan Michael 
Published: May 2021

AbstractThe sequencing of tumour or blood samples is increasingly used to stratify patients into clinical trials of molecularly targeted agents, and this approach has frequently demonstrated clinical benefit for those who are deemed eligible. But what of those who have no clear and evident molecular driver? What of those deemed to have “nil actionable” mutations? How might we deliver better therapeutic opportunities for those left behind in the clamour toward stratified therapeutics? And what significant learnings lie hidden in the data we amass but do not interrogate and understand? This Perspective article suggests a holistic approach to the future treatment of such patients, and sets a framework through which significant additional patient benefit might be achieved. In order to deliver upon this framework, it encourages and invites the clinical community to engage more enthusiastically and share learnings with colleagues in the early drug discovery community, in order to deliver a step change in patient care.
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair
Authors: Zhang Shaolu , Peng Xin , Li Xiaofei , Liu Hongyan , Zhao Baoquan , Elkabets Moshe , Liu Yao , Wang Wei , Wang Ran , Zhong Yuxu , Kong Dexin 
Published: May 2021

AbstractPARP inhibitors have been approved for the therapy of cancers with homologous recombination (HR) deficiency based on the concept of “synthetic lethality”. However, glioblastoma (GBM) patients have gained little benefit from PARP inhibitors due to a lack of BRCA mutations. Herein, we demonstrated that concurrent treatment with the PARP inhibitor rucaparib and the PI3K inhibitor BKM120 showed synergetic anticancer effects on GBM U251 and U87MG cells. Mechanistically, BKM120 decreased expression of HR molecules, including RAD51 and BRCA1/2, and reduced HR repair efficiency in GBM cells, therefore increasing levels of apoptosis induced by rucaparib. Furthermore, we discovered that the two compounds complemented each other in DNA damage response and drug accumulation. Notably, in the zebrafish U87MG-RFP orthotopic xenograft model, nude mouse U87MG subcutaneous xenograft model and U87MG-Luc orthotopic xenograft model, combination showed obviously increased antitumor efficacy compared to each monotherapy. Immunohistochemical analysis of tumor tissues indicated that the combination obviously reduced expression of HR repair molecules and increased the DNA damage biomarker γ-H2AX, consistent with the in vitro results. Collectively, our findings provide new insight into combined blockade of PI3K and PARP, which might represent a promising therapeutic approach for GBM.
HBO1 overexpression is important for hepatocellular carcinoma cell growth
Authors: Zhong Wenhui , Liu Heping , Deng Li , Chen Guohua , Liu Yubin 
Published: May 2021

AbstractHepatocellular carcinoma (HCC) is a common primary liver malignancy lacking effective molecularly-targeted therapies. HBO1 (lysine acetyltransferase 7/KAT7) is a member of MYST histone acetyltransferase family. Its expression and potential function in HCC are studied. We show that HBO1 mRNA and protein expression is elevated in human HCC tissues and HCC cells. HBO1 expression is however low in cancer-surrounding normal liver tissues and hepatocytes. In HepG2 and primary human HCC cells, shRNA-induced HBO1 silencing or CRISPR/Cas9-induced HBO1 knockout potently inhibited cell viability, proliferation, migration, and invasion, while provoking mitochondrial depolarization and apoptosis induction. Conversely, ectopic overexpression of HBO1 by a lentiviral construct augmented HCC cell proliferation, migration and invasion. In vivo, xenografts-bearing HBO1-KO HCC cells grew significantly slower than xenografts with control HCC cells in severe combined immunodeficient mice. These results suggest HBO1 overexpression is important for HCC cell progression.