bluuebunny/crossref_metadata_2025_split huggingface dataset:
BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program
Authors: Kim Dae-Hwan , Sun Duanchen , Storck William K. , Welker Leng Katherine , Jenkins Chelsea , Coleman Daniel J. , Sampson David , Guan Xiangnan , Kumaraswamy Anbarasu , Rodansky Eva S. , Urrutia Joshua A. , Schwartzman Jacob A. , Zhang Chao , Beltran Himisha , Labrecque Mark P. , Morrissey Colm , Lucas Jared M. , Coleman Ilsa M. , Nelson Peter S. , Corey Eva , Handelman Samuel K. , Sexton Jonathan Z. , Aggarwal Rahul , Abida Wassim , Feng Felix Y. , Small Eric J. , Spratt Daniel E. , Bankhead Armand , Rao Arvind , Gesner Emily M. , Attwell Sarah , Lakhotia Sanjay , Campeau Eric , Yates Joel A. , Xia Zheng , Alumkal Joshi J. 
Published: June 2021

Abstract

Purpose:
Lineage plasticity in prostate cancer—most commonly exemplified by loss of androgen receptor (AR) signaling and a switch from a luminal to alternate differentiation program—is now recognized as a treatment resistance mechanism. Lineage plasticity is a spectrum, but neuroendocrine prostate cancer (NEPC) is the most virulent example. Currently, there are limited treatments for NEPC. Moreover, the incidence of treatment-emergent NEPC (t-NEPC) is increasing in the era of novel AR inhibitors. In contradistinction to de novo NEPC, t-NEPC tumors often express the AR, but AR's functional role in t-NEPC is unknown. Furthermore, targetable factors that promote t-NEPC lineage plasticity are also unclear.

Experimental Design:
Using an integrative systems biology approach, we investigated enzalutamide-resistant t-NEPC cell lines and their parental, enzalutamide-sensitive adenocarcinoma cell lines. The AR is still expressed in these t-NEPC cells, enabling us to determine the role of the AR and other key factors in regulating t-NEPC lineage plasticity.

Results:
AR inhibition accentuates lineage plasticity in t-NEPC cells—an effect not observed in parental, enzalutamide-sensitive adenocarcinoma cells. Induction of an AR-repressed, lineage plasticity program is dependent on activation of the transcription factor E2F1 in concert with the BET bromodomain chromatin reader BRD4. BET inhibition (BETi) blocks this E2F1/BRD4-regulated program and decreases growth of t-NEPC tumor models and a subset of t-NEPC patient tumors with high activity of this program in a BETi clinical trial.

Conclusions:
E2F1 and BRD4 are critical for activating an AR-repressed, t-NEPC lineage plasticity program. BETi is a promising approach to block this program.
Factual power loss reduction by dynamic membrane evolutionary algorithm
Authors: Kanagabasai Lenin 
Published: June 2021

<p class="papertitle">This paper presents Dynamic Membrane Evolutionary Algorithm (DMEA) has been applied to solve optimal reactive power problem.Proposed methodology merges the fusion and division rules of P systems with active membranes and with adaptive differential evolution (ADE), particle swarm optimization (PSO) exploration stratagem. All elementary membranes are amalgamated into one membrane in the computing procedure. Furthermore, integrated membrane are alienated into the elementary membranes 1, 2,_ m. In particle swarm optimization (PSO) 𝑪<sub>𝟏</sub>, 𝑪<sub>𝟐</sub> (acceleration constants) are vital parameters to augment the explorationability of PSO in the period ofthe optimization procedure.In this work, Gaussian probability distribution isinitiated to engenderthe accelerating coefficients of PSO.Proposed Dynamic Membrane Evolutionary Algorithm (DMEA) has been tested in standard IEEE 14, 30, 57, 118, 300 bus test systems and simulation results show the projected algorithm reduced the real power loss comprehensively.</p>
Analysis of thermal-electrical performance of PVT collector with reflectors
Authors: Boulaich Hanan , Benkaddour Assia , Hamdoun Ouafae , Aroudam Elhassan 
Published: June 2021

<span lang="EN-US">This work concerns numerical studies of PVT air collector operating in dynamic mode. We presented the temperature of the solar cells and of the air at the outlet of the PVT collector with and without reflectors. The obtained simulation results has been validated by comparating with the experimental results available in literature, where good agreement was been noted. In addition, we determine the optimal position of the reflectors by numerical calculation, in order to obtain the maximal concentration of the solar radiation intensity on PV/T collector. </span><span lang="EN-US">The thermal and electrical efficiency of PV/T collector without reflectors and with reflectors in optimal position have been calculated for composite climate at Tetouan (-5°N, 35.5°E). </span><span lang="EN-US">So, the effect of adding solar reflectors on the electrical and thermal performance </span><span lang="EN-US">is showing</span><span lang="EN-US">.</span>
No pain, no gain? Sentidos e significados atribuídos às dores e aos riscos entre malhar e treinar em academias de ginástica
Authors: Silva Alan Camargo , Ferreira Jaqueline 
Published: June 2021

O objetivo dessa pesquisa etnográfica foi analisar e discutir os sentidos e os significados atribuídos às dores corporais e aos riscos no que diz respeito aos esforços físicos pelos alunos e pelos profissionais de Educação Física em duas academias de ginástica no Rio de Janeiro: uma de pequeno porte em um bairro popular (P) e outra de grande porte em um bairro nobre (G) da cidade. Na linha teórico-metodológica do interacionismo simbólico, foi realizada uma etnografia comparativa no espaço da musculação das duas academias. Observou-se que os “limites” das dores corporais durante os exercícios físicos e as noções de risco à saúde foram representados de formas plurais a depender dos contextos e dos grupos sociais. Os profissionais de ambos os estabelecimentos tendiam a exigir o máximo de esforços físicos dos seus alunos. Na academia P, o culto às dores e aos riscos era uma forma de cuidar de si. Os alunos concebiam o corpo como um “bem” a ser constantemente malhado. Na academia G, privilegiava-se a sociabilidade em função da exaustão dos exercícios físicos. Para os alunos, sentir dor ou estar em risco simbolizava danos ao corpo compreendido como um “patrimônio” a ser treinado. Mais do que um dado físico-biológico representado pelo sacrifício e sofrimento corporal, a forma de sentir dor e o que se entende por risco à saúde podem revelar os múltiplos lugares sociais dos pesquisados. Estes aspectos tornam-se importantes para a produção de conhecimento e a intervenção profissional no campo da Saúde e na área de Educação Física, pois ajudam entender e particularizar as ações e reflexões acadêmico-profissionais na relação com o outro para além do referencial técnico-científico da racionalidade biomédica.
Impact of Predilation During Transcatheter Aortic Valve Replacement: Insights From the PARTNER 3 Trial
Authors: Ternacle Julien , Al-Azizi Karim , Szerlip Molly , Potluri Srinivasa , Hamandi Mohanad , Blanke Philipp , Leipsic Jonathon , Dahou Abdellaziz , Salaun Erwan , Vincent Flavien , Rogers Erin , Alu Maria C. , Lu Michael , Yu Xiao , Thourani Vinod H. , Hahn Rebecca T. , Leon Martin B. , Pibarot Philippe , Mack Michael J. 
Published: June 2021

Background:
The use of predilation during transcatheter aortic valve replacement (TAVR) is variable, and its association with outcomes remains unknown. We evaluated the impact of predilation versus no predilation (direct TAVR) in the low-risk population enrolled in the PARTNER 3 trial (Placement of Aortic Transcatheter Valves).

Methods:
In the PARTNER 3 trial, 495 patients with severe symptomatic aortic stenosis underwent TAVR with the SAPIEN 3 valve. The use of predilation was left to operator discretion. The primary end point was a composite of all-cause death, stroke, or rehospitalization. Secondary end points included valve hemodynamic performance and the need for postdilation. Propensity score matching was performed.

Results:

Predilation and direct TAVR were performed in 286 (57.8%) and 209 (42.2%) patients, respectively. Before matching, the primary end point occurrence at 30 days (3.8% versus 4.8%,
P
=0.604) and 1 year (8.7% versus 8.1%,
P
=0.831) was similar in the predilation versus direct TAVR groups. Similar results were observed after matching (202 patients in each groups). Incidence of ≥ mild paravalvular regurgitation was similar in both groups. Incidence of severe prosthesis-patient mismatch was low but higher in the predilation group versus the direct TAVR group (8.2% versus 2.6%,
P
=0.023). Compared with direct TAVR, the use of predilation was associated with longer procedure duration (63.2 versus 51.4 minutes,
P
=0.001), while the rate of postdilation did not differ between the 2 groups (24.8% versus 18.8%,
P
=0.150).

Conclusions:
Predilation and direct TAVR are safe in patients with low surgical risk and favorable aortic valve anatomy. Direct TAVR decreased the procedure duration and did not predispose to more postdilation.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02675114.
Post-Classical Greek Elegy and Lyric Poetry
Authors: Greene Robin J. 
Published: June 2021

Abstract
This volume traces the development of Greek elegy and lyric in the hands of Hellenistic and Roman-era poets, from literary superstars such as Callimachus and Theocritus to more obscure, often anonymous authors. Designed as a guide for advanced students and scholars working in adjacent fields, this volume introduces and explores the diverse body of surviving later Greek elegy and lyric, contextualizes it within Hellenistic and Roman culture and politics, and surveys contemporary critical interpretations, methodological approaches, and avenues for future study.
Decadal and Multidecadal Variability in ERSSTv5 Global SST during 1879–2018
Authors: Frederiksen Carsten S. , Zheng Xiaogu , Grainger Simon 
Published: June 2021

AbstractDecadal and multidecadal variability in the ERSSTv5 global SST dataset are studied in terms of implicit fast (noise) and slow (signal) processes that affect variability on decadal time scales. Using a new method that better estimates the fast, or noise, component of decadal variability, estimates of the modes of variability in the slow component are possible. The fast component of decadal variability has a leading fast mode, which explains 62% of the variance, and it is shown that this fast variability, or decadal climate noise, is well represented by any of the indices associated with intradecadal or interannual variability in the tropical Pacific Ocean. Three slow modes are identified, representing 69% of the slow multidecadal variance, after removing the radiative forcing trend. These modes are shown to be related to variability in the Atlantic multidecadal oscillation (AMO) and SST multidecadal variability in the central western Pacific and in the Indian Ocean gyre region, respectively. The first and third slow modes represent two phases of a propagating mode with a period of about 80 years. The second slow mode represents multidecadal variability of the western Pacific warm pool, which is less robust than the other two and shown to be weakly related to the AMO with a lag of about 30 years; fast variability in this region is related to the leading fast mode. Three regions of significant slow variability are identified south of Australia, south of Africa, and near the Drake Passage in association with the Antarctic Circumpolar Current.
Antarctic Peninsula Regional Circulation and its Impact on the Surface Melt of Larsen C Ice Shelf
Authors: Zhang Chongran , Zhang Jing , Wu Qigang 
Published: June 2021

AbstractEnhanced surface melt over the ice shelves of the Antarctic Peninsula (AP) is one of the precursors to their collapse, which can be proceeded by accelerated ground glacier flow and increased contribution to sea level rise. With the collapse of Larsen A and B, and the major 2017 calving event from Larsen C, whether Larsen C is bound for a similar fate has received increasing attention. Here, the interannual variation of regional circulation over the AP region is studied using the Empirical Orthogonal Function (EOF) / Principal Component (PC) analysis on the sea level pressure of ERA5 reanalysis. The EOF modes capture the variations of depth, location and extent of Amundsen Sea Low and Weddell Sea Low in each season. Statistically significant positive correlations exist between Larsen C surface temperature and the PC time series of EOF mode 1 in winter and spring through northerly/northwesterly wind anomalies west of the AP. The PC time series of EOF mode 2 is negatively correlated with Larsen C surface temperature in autumn and summer and surface melt in summer, all due to southerly wind anomalies east of the AP. Surface energy budget analysis associated with EOF mode 2 shows that downwelling longwave radiation over Larsen C is negatively statistically significantly, correlated with EOF mode 2 and is the major atmospheric forcing regulating the variation of Larsen C surface melt. Positively enhanced EOF mode 2 since 2004 is responsible for the recent cooling and decline of surface melt over Larsen C.
Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis
Authors: Atar Yavuz , Karaketir Semih , Aydogdu Imran , Sari Hüseyin , Bircan Hasan Sami , Uyar Yavuz , Ekincioglu Enis , Karaketir Seyma Görcin , Atac Enes , Berkiten Güler 
Published: June 2021

Objective: We aim to demonstrate the effect of an isotonic seawater spray containing chamomile liquid extract on symptoms and nasal mucociliary clearance in patients with allergic rhinitis by comparing it with other isotonic seawater nasal washing solutions. Methods: The study included 123 patients. Based on Allergic Rhinitis and its Impact on Asthma guidelines, mometasone furoate intranasal spray treatment was started for all patients in the group diagnosed with allergic rhinitis. In addition to this treatment, isotonic seawater spray with chamomile liquid extract was added to Group A, isotonic seawater spray to Group B, and isotonic seawater nasal irrigation to Group C. The fourth group (Group D) was given only nasal steroid spray without nasal washing treatment. Before and after treatment in all patients, the Sino-Nasal Outcome Test-22 was performed, and nasal mucociliary clearance times were measured by the saccharin test. Results: The differences in duration of nasal mucociliary clearance and Sino-Nasal Outcome Test-22 values were taken before and after treatment. In Group A, B, C, and D the Sino-Nasal Outcome Test-22 differences were statistically significant ( P ≤.001; P ≤ .001; P ≤ .001, and P = .048, respectively). Only Group A and Group B experienced a significant difference in nasal mucociliary clearance times ( P ≤ .001; P = .010, respectively). When the Sino-nasal Outcome Test-22 score and nasal mucociliary clearance time differences before and after treatment were compared between all groups, the Sino-Nasal Outcome Test-22 score difference was higher in Group A than in Groups B, C, and D, the differences were found as statistically significant ( P = .010; P = .003; P ≤ .001, respectively). The nasal mucociliary clearance time difference was higher in Group A than in Groups C and D, the differences were found as statistically significant ( P = .010; P = .001, respectively). Conclusion: Isotonic seawater spray containing chamomile liquid extract is seen as a good alternative treatment option for allergic rhinitis patients.
Putting the Neoliberal Transformation of Turkish Healthcare System and Its Problems into a Historical Perspective
Authors: Konuralp Emrah , Bicer Sermin 
Published: June 2021

The principal objective of this article is to analyze how the Health Transformation Program (HTP), the latest reform to have overhauled the Turkish healthcare system, has been designed according to the project of global neoliberal capital accumulation. This reform is in line with the transformation of the Turkish economy, which has been ongoing since the 1980s. With this aim in mind, this research examines how neoliberalism affects both the provision of healthcare services and household healthcare expenditures in Turkey. The article concludes that, as well as the HTP transferring public funds to the private sector and promoting the rent-seeking characteristic of the Turkish bourgeoisie, the financial burden of healthcare services on primarily the middle and lower-income groups in Turkey has increased dramatically and led to a rise in out-of-pocket expenditures. JEL Classification: H51, I14
Low Rate of Peri-implant Osteolysis in Trabecular Metal Total Ankle Replacement on Short- to Midterm Follow-up
Authors: Kormi Sami , Kohonen Ia , Koivu Helka , Tiusanen Hannu 
Published: June 2021

Background: Peri-implant osteolysis is one of the major complications related to total ankle replacement. The aim of this study was to investigate the short- to midterm incidence of peri-implant osteolysis using computed tomography (CT) as imaging method for the Trabecular Metal Total Ankle (TMTA) implant representing a novel total ankle replacement (TAR) implant design regarding material and surgical technique. Methods: In total, 104 consecutive patients who had a primary TMTA replacement between March 2013 and October 2017 were included in the study. The radiographic evaluation included weightbearing anteroposterior and lateral views at baseline and after 3, 6, and every 12 months postoperatively. A helical CT was undertaken preoperatively and of the 80 patients available to follow up at least 12 months postoperatively, with average time interval between the TAR operation and the latest CT of 39 (range, 12-85) months. Results: Eight of 80 patients had altogether 11 osteolytic lesions around the components on CT images. Seven lesions were found in tibia, 3 in talus, and 1 in distal fibula. Four of the tibial lesions were situated in the medial malleolus and were not in contact with the prosthesis component. The sizes of the osteolytic lesions ranged between 7 and 20 mm, and the average volume of the lesions was 689 mm3. Conclusion: We conclude that the risk of peri-implant osteolysis with the TMTA implant is minimal in short to midterm. The anatomic configuration, unique material, and surgical technique may all contribute to the TMTA implant having a low rate of peri-implant osteolysis. Level of Evidence: Level IV, case series.
Developing an infrastructure for secure patient summary exchange in the EU context: Lessons learned from the KONFIDO project
Authors: Natsiavas Pantelis , Mazzeo Giovanni , Faiella Giuliana , Campegiani Paolo , Dumortier Jos , Stan Oana , Nalin Marco , Mari Martinez David , Theodouli Anastasia , Moschou Kostas , Votis Kostas , Coppolino Luigi , Romano Maria , Tzovaras Dimitris , Clemente Fabrizio , Gelenbe Erol , Romano Luigi 
Published: June 2021

Background: The increase of healthcare digitalization comes along with potential information security risks. Thus, the EU H2020 KONFIDO project aimed to provide a toolkit supporting secure cross-border health data exchange. Methods: KONFIDO focused on the so-called “User Goals”, while also identifying barriers and facilitators regarding eHealth acceptance. Key user scenarios were elaborated both in terms of threat analysis and legal challenges. Moreover, KONFIDO developed a toolkit aiming to enhance the security of OpenNCP, the reference implementation framework. Results: The main project outcomes are highlighted and the “Lessons Learned,” the technical challenges and the EU context are detailed. Conclusions: The main “Lessons Learned” are summarized and a set of recommendations is provided, presenting the position of the KONFIDO consortium toward a robust EU-wide health data exchange infrastructure. To this end, the lack of infrastructure and technical capacity is highlighted, legal and policy challenges are identified and the need to focus on usability and semantic interoperability is emphasized. Regarding technical issues, an emphasis on transparent and standards-based development processes is recommended, especially for landmark software projects. Finally, promoting mentality change and knowledge dissemination is also identified as key step toward the development of secure cross-border health data exchange services.
The Benefit of Enhanced Daycare of Traditional Chinese Medicine for Cancer Treatment Related Adverse Events: A Retrospective Study of Medical Records
Authors: Wu Hsiu-An , Chen Chien-Hung , Hsieh Ming-Hsien , Wu Yung-Chang , Chiu Jung-Peng , Huang Chien-Jung , Hsu Chung-Hua 
Published: June 2021

Objective: Cancer patients undergo therapies that might lead to severe adverse events. The enhanced daycare of Traditional Chinese medicine (TCM) we describe was intended to help cancer patients suffering from severe adverse events to obtain relief. We used the Taiwan brief version of the Common Terminology Criteria for Adverse Events Version 4.0 (Taiwan brief version questionnaire of CTCAE) as a primary measurement to evaluate the efficacy of the enhanced day care of TCM. The secondary measurements were the Taiwanese version of the Brief Fatigue Inventory (BFI-T) questionnaire and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire, which were used to quantify fatigue and quality of life (QOL), respectively. Methods/Design: This is a retrospective study of medical records. There were 401 patients treated with enhanced daycare of TCM from June 2017 to November 2019. Results: Among 22 common adverse symptoms in the Taiwan brief version questionnaire of CTCAE4.0, 14 symptoms achieved a significant improvement, and the change of the total scores was also statistically significant ( P < .001). Cancer stages II to IV showed significant improvement on the CTCAE and BFI-T; stage I only showed improvement on the BFI-T. On the WHOQOL questionnaire, there was a statistically significant difference in self-evaluation of the quality of life ( P = .001) and self-evaluation of the total health condition aspect ( P < .001). Conclusions: The enhanced TCM daycare program helped cancer patients decrease the severity of their adverse events and improve their fatigue and QOL. ClinicalTrials.gov identifier: NCT04606121.
Comparison of one-year patency rates of end-to-side and side-to-side anastomosis technique in proximal forearm region radial-cephalic fistulas
Authors: Kasimzade Ferit , Ada Fatih 
Published: June 2021

Objectives In this study, the effects of anastomosis techniques on the results of patients with autogenous radial-cephalic proximal forearm fistula were investigated. Methods Patients who underwent radial-cephalic proximal forearm fistula surgery (arteriovenous fistula) between April 2015 and August 2017 at the Department of Cardiovascular Surgery of Ordu University were compared retrospectively in terms of the results of anastomosis techniques. The study included 131 patients who had arteriovenous fistulas created by side-to-side and end-to-side anastomosis technique. Results There was no significant difference in demographic data, comorbidities, radial artery, and cephalic vein diameters in patients undergoing radial-cephalic proximal forearm fistula surgery. However, it was observed that fistula maturation was earlier in the group with end-to-side anastomosis technique, and the one-year patency rates were higher in the group with side-to-side anastomosis technique. Conclusion In Arteriovenous fistulas created in the proximal forearm region, the one-year patency rate of the side-to-side anastomosis technique was higher, while the maturation of the end-to-side technique observed earlier.