bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diritto italiano: Famiglia
Authors:   Redazione
Published: June 2021

1. Corte di cassazione 5.5.2010 n. 10880 - ricongiungimento familiare - condizione ostativa all'ingresso in Italia rappresentata dall'aver riportato condanne penali - necessità di dimostrare la concretezza e attualità della minaccia per l'ordine pubblico o la sicurezza dello Stato - esclusione SCHEDA di Massimo Pastore e Chiara Favilli2. Corte appello di Milano 8.1.2010 - ricongiungimento familiare con genitori a carico - nulla osta rilasciato prima delle modifiche introdotte dal d.lgs. 160/08 - richiesta di visto d'ingresso - possibilità di rivalutazione dei requisiti in base allo jus superveniens da parte dell'autorità consolare - esclusione3. Tribunale di Vicenza 6.4.2010 - diritto di soggiorno del coniuge di cittadino italiano o comunitario - possibilità di limitazione per pregressa irregolarità del soggiorno - esclusione - diritto al rilascio della carta di soggiorno per familiare di cittadino UE
Diritto italiano: Penale
Authors:   Redazione
Published: June 2021

1. Ufficio di sorveglianza di Livorno 18.5.2009 - espulsione come misura di sicurezza e libertà vigilata - divieto sottoposizione dell'espellendo a pene o trattamenti inumani o degradanti ex art. 3 CEDU - divieto assoluto e inderogabile di espulsione2. Tribunale di Venezia 26.10.2009 - istigazione alla commissione di atti di discriminazione per motivi razziali, etnici, nazionali e religiosi - razzismo e discriminazione - nozioni - limiti all'esercizio alla libera manifestazione del pensiero
Diritto italiano: Soggiorno
Authors:   Redazione
Published: June 2021

1. Consiglio di Stato 17.2.2009 n. 896 - carta di soggiorno e permesso di soggiorno - diversità dei due istituti - diniego di rilascio per entrambi a seguito di condanna per reati relativi alla tutela del diritto d'autore - illegittimità per errata equiparazione dei due status - esclusione di automatismo per soggiornanti di lungo periodo anche prima dell'attuazione della Direttiva 2003/109/CE - rilevanza del tempo di soggiorno2. Tribunale amministrativo regionale Veneto 3.7.2009 n. 2104 - diniego rinnovo permesso di soggiorno per attesa occupazione - insufficienza reddito e fonti sostentamento - omessa considerazione delle fonti di reddito del coniuge - omessa valutazione dell'effettività del vincolo familiare3. Tribunale amministrativo regionale Emilia Romagna 29.5.2009 n. 859 - richiesta di nulla osta lavorativo per l'ingresso di straniero (decreto flussi) - diniego motivato da presunta insufficienza reddituale - mancata valutazione del maggior reddito conseguito successivamente alla richiesta - illegittimità del diniego; capacità reddituale del datore di lavoro commisurata al doppio dell'importo della retribuzione spettante al futuro lavoratore4. Tribunale amministrativo regionale Piemonte 8.2.2010 n. 981 - permesso CE per soggiornanti di lungo periodo - revoca per intervenuta condanna ostativa (reato in materia di stupefacenti) - omessa valutazione dei criteri (durata del soggiorno, inserimento lavorativo e sociale) indicati dall'art. 9 TU n. 286/98 riformato dal d.lgs. 3/2007 per valutare la concreta pericolosità sociale - illegittimità5. Tribunale amministrativo regionale Umbria 28.5.2009 n. 263 - permesso CE per soggiornanti di lungo periodo - richiesta per il coniuge soggiornante in Italia da meno di 5 anni - diniego per difetto del requisito quinquennale - illegittimità; verifica del requisito della permanenza quinquennale esclusivamente per il titolare del diritto; familiare di straniero titolare di permesso CE per soggiornanti di lungo periodo - diversità di condizione giuridica in caso di separazione o divorzio o perdita del diritto da parte del titolare
Implementasi Program Gerakan Literasi Sekolah di Sekolah Menengah Pertama (SMP)
Authors: Widodo Antoni 
Published: June 2021

Artikel ini bertujuan untuk mengetahui implementasi program Gerakan Literasi Sekolah (GLS) di SMP IT Insan Harapan Kota Tangerang Selatan. Jenis penelitian ini menggunakan kualitatif deskriptif. Informan penelitian meliputi Kepala Sekolah, Wakil Kepala Sekolah Bidang Kurikulum, Guru, dan Peserta didik. Instrumen penelitian menggunakan wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukan bahwa Gerakan Literasi Sekolah belum dilakukan dengan rutin. Upaya yang dilakukan oleh sekolah dalam mendukung Gerakan Literasi 1) Menyediakan buku bacaan yang beragam 2) Membuat kegiatan 2 jam membaca di hari jumat 3) melaksanakan 15 menit membaca sebelum pembelajaran di mulai 4)membuat laboratorium computer (warnet sekolah). Sedangkan kendala yang dihadapi dalam melaksanakan program Gerakan Literasi Sekolah (GLS) 1) tidak konsisten dalam penerapan 15 menit membaca sebelum pembelajaran di mulai 2) pelaksanaan yang tidak rutin dalam menerapkan kegiatan membaca 2 jam pembelajaran setiap minggu 3) masih kurangnya sarana dan prasana perpustakaan 4) kurangnya pengawasan dalam implementasi Gerakan Literasi Sekolah (GLS), implementasi program Gerakan Literasi Sekolah perlu adanya dukungan dari komponen sekolah seperti pengawas, Kepala Sekolah, dan Komite Sekolah.
PENGARUH MODEL COOPERATIVE LEARNING TYPE MAKE A MATCH TERHADAP PENGUASAAN KONSEPTUAL SISWA KELAS IV SD NEGERI 6 KAUR
Authors: Bastari Ginan Bastari , Koto Irwan Koto , Susanta Agus Susanta 
Published: June 2021

Penelitian ini bertujuan untuk mengetahui pengaruh model cooperative learning type make a match terhadap penguasaan konseptual siswa kelas IV SD Negeri 6 Kaur. Jenispenelitian ini adalah kuantitatif dengan metode eksperimen semu, dengan desain The Matching Only Pretest-Posttest Control Group Design yang dilaksanakan di kelas IV SD Negeri 6 Kaur. Populasi penelitian ini adalah seluruh siswa kelas IV SD Negeri 6 Kaur. Sampel yang dipilih adalah kelas IVA yang berjumlah 18 siswa sebagai kelas eksperimen, kelas IVB yang berjumlah 18 siswa sebagai kelas kontrol. Teknik pengumpulan data dilakukan dengan tes Pretest-Posttest sebanyak 20 soal obyektif dan 20 soal angket. Data hasil penelitian ini dianalisis dengan menggunakan analisis deskriptif dan inferensial yaitu uji-t. Data hasil penelitian diketahui bahwa nilai rata-rata pretest kelas ekperimen (40,83 ; SD=13,15) dan posttestkelas eksperimen (87,87 ; SD=9,59). Hasil persentase kenaikan nilai rata-rata hasil belajar aspek kognitif kelas kontrol 86,9% dan eksperimen 115,2%. Kenaikan persentase nilai pada kelas eksperimen lebih besar dari pada kelas kontrol, dapat dilihat dari perbedaan kenaikan hasil belajar kognitif sebesar 28,3%.Maka diperoleh hasil perhitungan Uji-t pada aspek kognitif yaitu thitung (6,074) >ttabel (1,697). Nilai thitung yang diperoleh lebih besar dari nilai ttabel maka dapat disimpulkan bahwa terdapat pengaruh Model Cooperative Learning Type Make a Match Terhadap Penguasaan Konseptual Dan Siswa Kelas IV SD Negeri 6 Kaur.
PENERAPAN DISCOVERY LEARNING UNTUK MENINGKATKAN EFIKASI DIRI DAN HOTS PADA TEMA DAERAH TEMPAT TINGGALKU SISWA KELAS IV A MIN 1 KOTA BENGKULU
Authors: SUmini Sumini SUmini , Winarni Endang Widi , Koto Irwan Koto 
Published: June 2021

The objectives of this research to improve students’ selff efficacy and HOTS. This research was a classroom action research done in 3 cycles performed, each cycle was consist of four stages namely: planning, acting, observing, and reflecting. The action research was done in class IVA, consist of 34 students, 16 female students, and 18 male students. The data were collected by an observation sheet, a questionnaire, and a test of HOTS. Then, the data were analyzed by avarage, percentage, and classification. The results of research showed that the teaching activity, self efficacy, HOTS were improved, and discovery learning effectively improve students’ HOTS. Reccomendation of this research were: 1) the teachers should guide and correct the students’ work, then encourage, reinforcement, even giving reward to students; 2) the teachers should direct the students to develop the knowledge to the environment activity, and inrease references; 3) the teachers should guide the students to connect the answers to their daily experiment; and 4) for the further research, reccommended to conduct the spesific about ability of students’ to answer the question by creation using discovery learning.
Penerapan Pembelajaran Menulis Puisi Dengan Teknik Kata Kunci
Authors: Muktadir Abdul Muktadir , Ariffiando Nady Febri 
Published: June 2021

Penelitian ini bertujuan untuk meningkatkan keterampilan menulis puisi dengan menggunakan teknik kata kunci. Metode penelitian dilakukan adalah PTK yang berdaur silkus melalui prosedur perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian adalah mahasiswa S-2 PGSD semester I. Data penelitian adalah tes, pengamatan dan dokumentasi. Instrumen yang digunakan adalah lembaran observasi mahasiswa, lembar penilaian keterampilan. Data hasil observasi akan dianalisis secara deskriptif, data hasil tes dianalisis menggunakan rata-rata. Hasil penelitian menyimpulkan: 1) Langkah-langkah penerapan teknik kata kunci dapat meningkatkan proses hasil pembelajaran menulis puisi mahasiswa, 2) Pemilihan tema menulis puisi berdasarkan lingkungan pembelajaran memudahkan mahasiswa dalam menuangkan idenya.
A Novel Prognostic Biomarker of Luminal Breast Cancer: High CD39 Expression Is Related to Poor Survival
Authors: Ni Xiaojian , Wan Wenze , Ma Jingjing , Liu Xinyou , Zheng Bohao , He Zhixian , Yang Weige , Huang Lihong 
Published: June 2021

BackgroundCD39 is one of the functional surface markers for T regulatory cells, the prognostic role and immune-related effects of CD39 in luminal breast cancer (BC) patients has not been evaluated yet. The aim of the current study was to explore the association between CD39 expression and clinic pathological characteristics and the prognosis in luminal BC patients.MethodsClinical information and RNA-sequencing (RNA-Seq) expression data were extracted from The Cancer Genome Atlas (TCGA). Patients were divided into a high or low CD39 expression group by the optimal cutoff value (4.18) identified from the receiver operating characteristic curve analysis. The relationships between CD39 expression and clinic pathological features were evaluated by the corresponding statistical tests. Survival analyses were applied to evaluate the overall survival between the high and low CD39 expression groups in luminal BC. Furthermore, Gene Expression Omnibus datasets were used for external data validation. Gene set enrichment analysis (GSEA) was also performed, and CIBERSORT was used to analyze the immune cell populations.ResultsAnalysis of 439 cases of tumor data showed that CD39 was overexpressed in luminal BC. The multivariable analysis suggested that CD39 expression was an independent prognostic factor for luminal BC patients. GSEA suggested that CD39 might play an important role in luminal BC progression through immune regulation. Analysis of immune cell patterns revealed high CD39 expression correlated to a higher proportion of CD8+ T cells and M2 macrophages.ConclusionThis study demonstrates that CD39 expression correlates with the prognosis of luminal BC through TCGA database mining. Further studies are warranted further to elucidate this potential novel therapeutic strategy for BC.
Novel Predictors of Future Vascular Events in Post-stroke Patients—A Pilot Study
Authors: Schrick Diana , Ezer Erzsebet , Tokes-Fuzesi Margit , Szapary Laszlo , Molnar Tihamer 
Published: June 2021

Introduction: A modified platelet function test (mPFT) was recently found to be superior compared to impedance aggregometry for selection of post-stroke patients with high on-treatment platelet reactivity (HTPR). We aimed to explore some peripheral blood cell characteristics as predictors of recurrent ischemic episodes. The predictive value of mPFT was also assessed in a cohort followed up to 36 months regarding recurrent ischemic vascular events.Methods: As a novelty, not only whole blood (WB), but after 1-h gravity sedimentation the separated upper (UB) and lower half blood (LB) samples were analyzed including neutrophil antisedimentation rate (NAR) in 52 post-stroke patients taking clopidogrel. Area under the curve (AUC, AUCupper and AUClower, respectively) was separately measured by Multiplate in the WB, UB and LB samples to characterize ex vivo platelet aggregation in the presence of ADP. Next, the occurrence of vascular events (stroke, acute coronary syndrome, ACS) were evaluated during 36-month follow-up.Results: A total of 11 vascular events (stroke n = 5, ACS n = 6) occurred during the follow-up period. The AUCupper was significantly higher in patients with recurrent stroke compared to those with uneventful follow-up (p = 0.03). The AUCupper with a cut-off value ≥70 based on the mPFT, was able to predict all stroke events (p = 0.01), while the total vascular events were independently predicted by NAR with a sensitivity of 82% and specificity of 88%.Conclusions: A combination of NAR reflecting the inflammatory state and AUCupper indicating HTPR may provide a better prediction of recurrent ischemic events suggesting a better selection of patients at risk, thus providing an individually tailored vascular therapy.
Influence of Onset to Imaging Time on Radiological Thrombus Characteristics in Acute Ischemic Stroke
Authors: Tolhuisen Manon L. , Kappelhof Manon , Dutra Bruna G. , Jansen Ivo G. H. , Guglielmi Valeria , Dippel Diederik W. J. , van Zwam Wim H. , van Oostenbrugge Robert J. , van der Lugt Aad , Roos Yvo B. W. E. M. , Majoie Charles B. L. M. , Caan Matthan W. A. , Marquering Henk A. ,   the MR CLEAN Registry Investigators
Published: June 2021

Introduction: Radiological thrombus characteristics are associated with patient outcomes and treatment success after acute ischemic stroke. These characteristics could be expected to undergo time-dependent changes due to factors influencing thrombus architecture like blood stasis, clot contraction, and natural thrombolysis. We investigated whether stroke onset-to-imaging time was associated with thrombus length, perviousness, and density in the MR CLEAN Registry population.Methods: We included 245 patients with M1-segment occlusions and thin-slice baseline CT imaging from the MR CLEAN Registry, a nation-wide multicenter registry of patients who underwent endovascular treatment for acute ischemic stroke within 6.5 h of onset in the Netherlands. We used multivariable linear regression to investigate the effect of stroke onset-to-imaging time (per 5 min) on thrombus length (in mm), perviousness and density (both in Hounsfield Units). In the first model, we adjusted for age, sex, intravenous thrombolysis, antiplatelet use, and history of atrial fibrillation. In a second model, we additionally adjusted for observed vs. non-observed stroke onset, CT-angiography collateral score, direct presentation at a thrombectomy-capable center vs. transfer, and stroke etiology. We performed exploratory subgroup analyses for intravenous thrombolysis administration, observed vs. non-observed stroke onset, direct presentation vs. transfer, and stroke etiology.Results: Median stroke onset-to-imaging time was 83 (interquartile range 53–141) min. Onset to imaging time was not associated with thrombus length nor perviousness (β 0.002; 95% CI −0.004 to 0.007 and β −0.002; 95% CI −0.015 to 0.011 per 5 min, respectively) and was weakly associated with thrombus density in the fully adjusted model (adjusted β 0.100; 95% CI 0.005–0.196 HU per 5 min). The subgroup analyses showed no heterogeneity of these findings in any of the subgroups, except for a significantly positive relation between onset-to-imaging time and thrombus density in patients transferred from a primary stroke center (adjusted β 0.18; 95% CI 0.022–0.35).Conclusion: In our population of acute ischemic stroke patients, we found no clear association between onset-to-imaging time and radiological thrombus characteristics. This suggests that elapsed time from stroke onset plays a limited role in the interpretation of radiological thrombus characteristics and their effect on treatment results, at least in the early time window.
LncRNA HCP5 : A Potential Biomarker for Diagnosing Gastric Cancer
Authors: Qin Shiyi , Yang Lei , Kong Shan , Xu Yanhua , Liang Bo , Ju Shaoqing 
Published: June 2021

BackgroundIt has been reported that long non-coding RNAs (lncRNAs) can be regarded as a biomarker and had particular clinical significance for early screening and gastric cancer (GC) diagnosis. Therefore, this study aimed to investigate whether serum HCP5 could be a new diagnostic biomarker.MethodsFiltered out the HCP5 from the GEO database. The specificity of HCP5 was verified by real-time fluorescence quantitative PCR (qRT-PCR), and then the stability of HCP5 was verified by room temperature storage and repeated freeze-thaw experiments. Meanwhile, the accuracy of HCP5 was verified by agarose gel electrophoresis (AGE) and Sanger sequencing. Simultaneously, the expression level of serum HCP5 was detected by qRT-PCR in 98 patients with primary gastric cancer, 21 gastritis patients, 82 healthy donors, and multiple cancer types. Then, the methodology analysis was carried on. Moreover, receiver operating characteristic (ROC) was used to evaluate its diagnostic efficiency.ResultsqRT-PCR method had good repeatability and stability in detecting HCP5. The expression level of HCP5 in the serum of gastric cancer patients was remarkably higher than that of healthy controls, and it could distinguish gastritis patients from healthy donors. Besides, the expression of HCP5 was increased dramatically in MKN-45 and MGC-803. The FISH assay showed that HCP5 was mainly distributed in the cytoplasm of MKN-45 and BGC-823 cells. When HCP5 was combined with existing tumor markers, the diagnostic efficiency of HCP5 was the best, and the combined diagnosis of carcinoembryonic antigen (CEA), carbohydrate antigen199 (CA199), and HCP5 can significantly improve the diagnostic sensitivity. Besides, compared with the expression levels of thyroid cancer (THCA), colorectal cancer (CRC), and breast cancer (BRCA), serum HCP5 in gastric cancer was the most specific. Moreover, the high expression of serum HCP5 was related to differentiation, lymph node metastasis, and nerve invasion. The term of serum HCP5 after the operation was significantly lower than that of patients with primary gastric cancer.ConclusionSerum HCP5 can be used as a potential biomarker of non-invasive fluid biopsy, which had a unique value in the early diagnosis, development, and prognosis of gastric cancer.
The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg
Authors: Niu Jianhong , Zhai Guangdi , Zheng Aibin , Zhou Juanying , Jiang Shengqi , Ma Jianping 
Published: June 2021

Objective:This study aims to investigate the effect of optimized ultrafiltration on perioperative electrolytes, acid–base balance, and pulmonary function during cardiopulmonary bypass (CPB) in infants with low body weight (under 10 kg), using traditional balanced ultrafiltration and modified ultrafiltration.Methods:A total of 30 children who underwent surgical correction for congenital heart disease in Changzhou Children's Hospital between January 2018 and December 2019 were randomly divided into two groups. In the treatment group, ultrafiltration pre-treatment was carried out with blood-containing priming fluid prior to CPB. Balanced ultrafiltration was performed during the operation, and optimized and modified ultrafiltration were conducted before closing and extubation. In the control group, traditional balanced ultrafiltration was used during the operation, and a modified ultrafiltration combination was used before closing and extubation. Indexes such as blood gas analysis and electrolytes were measured perioperatively, and pulmonary function was observed.Results:No deaths were reported in either group. The ventilator-assisted breathing time was shorter in the treatment group than in the control group (P&lt; 0.05). The indexes of the treatment group were closer than those of the control group to the optimal physiological values. The concentrations of potassium ion (K+), lactate (Lac), and blood glucose (Glu) decreased, and there was significant difference between the two groups (P&lt; 0.05) at the end of CPB. Hemoglobin (Hb) and hematocrit (HCT) in the treatment group increased (P&lt; 0.01). Alveolar-arterial differences for oxygen (A-aDO2) and respiratory index (RI) increased significantly in both groups after operation. Children in the treatment group began to recover lung function earlier than children in the control group. Both A-aDO2and RI were lower in the treatment group than in the control group at each time point after operation (P&lt; 0.05).Conclusion:Optimizing and modifying the traditional ultrafiltration combination method can effectively shorten the ultrafiltration time, reduce the adverse impacts of the ultrafiltration technique, and improve the lung function of infants after operation.
Biomodulatory Treatment Regimen, MEPED, Rescues Relapsed and Refractory Classic Hodgkin’s Disease
Authors: Lüke Florian , Harrer Dennis C. , Menhart Karin , Wolff Daniel , Holler Ernst , Hellwig Dirk , Herr Wolfgang , Grube Matthias , Vogelhuber Martin , Reichle Albrecht , Heudobler Daniel 
Published: June 2021

Introduction: Current combined intensive chemotherapy and radiation regimens yield excellent survival rates in advanced classic Hodgkin’s lymphoma (cHL). However, acute toxicity in elderly, comorbid patients can be challenging and long-term survival in refractory patients remains poor.Patients and Methods: We report on six patients with r/r HL, three patients with long-term follow-up, three newly treated, after biomodulatory therapy. All patients received MEPED (treosulfan 250 mg p.o. daily, everolimus 15 mg p.o. daily to achieve serum trough levels of 15 ng/ml, pioglitazone 45 mg p.o. daily, etoricoxib 60 mg p.o. daily and dexamethasone 0.5 mg p.o. daily). Patients had either received every at that time approved systemic treatment or were ineligible for standard treatment, including immune checkpoint inhibition (ICPi) due to prior demyelinating autoimmune polyneuropathy, myasthenia gravis and previous allogeneic hematopoietic-stem-cell transplant (alloHSCT). Medication was administered continuously from day 1. One patient with relapse after alloHSCT received trofosfamide 50 mg daily instead of treosulfan to avoid risk of increased myelotoxicity. The patients were treated in individual healing attempts outside a clinical trial after institutional review board approval. 18F-fluoro-2-deoxy-d-glucose positron emission tomography combined with computed tomography scan (FDG-PET/CT) was performed to monitor treatment and follow-up.Results: In the three newly treated patients, CT scans showed partial remissions after 2–5 months on MEPED treatment. Two patients had achieved PET Deauville score 2 and 3, while the third remained positive at Deauville score 5. One patient achieving PR became eligible for alloHSCT, while the other two patients continued treatment with MEPED. All patients eventually achieved continuous complete remission (cCR), one after consecutive alloHSCT, one after discontinuing MEPED consolidation for &gt;1 year and one on on-going MEPED consolidation, respectively. Only one patient experienced Grade 3 toxicity (bacterial pneumonia) requiring temporary discontinuation of MEPED for 10 days. All three previously published patients received allo HSCT for consolidation and have achieved cCR.Conclusions: MEPED is well tolerated with low toxicity and highly efficacious in relapsed/refractory cHL, including severely comorbid patients. Due to its immunomodulatory components, MEPED might also have a synergistic potential when combined with ICPi but requires further evaluation within a clinical trial.