bluuebunny/crossref_metadata_2025_split huggingface dataset:
European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus
Authors: Hammer Heinz F. , Fox Mark R. , Keller Jutta , Salvatore Silvia , Basilisco Guido , Hammer Johann , Lopetuso Loris , Benninga Marc , Borrelli Osvaldo , Dumitrascu Dan , Hauser Bruno , Herszenyi Laszlo , Nakov Radislav , Pohl Daniel , Thapar Nikhil , Sonyi Marc ,   European H‐CH‐breath test group
Published: August 2021

AbstractIntroductionMeasurement of breath hydrogen (H2) and methane (CH4) excretion after ingestion of test‐carbohydrates is used for different diagnostic purposes. There is a lack of standardization among centers performing these tests and this, together with recent technical developments and evidence from clinical studies, highlight the need for a European guideline.MethodsThis consensus‐based clinical practice guideline defines the clinical indications, performance, and interpretation of H2‐CH4‐breath tests in adult and pediatric patients. A balance between scientific evidence and clinical experience was achieved by a Delphi consensus that involved 44 experts from 18 European countries. Eighty eight statements and recommendations were drafted based on a review of the literature. Consensus (≥80% agreement) was reached for 82. Quality of evidence was evaluated using validated criteria.ResultsThe guideline incorporates new insights into the role of symptom assessment to diagnose carbohydrate (e.g., lactose) intolerances and recommends that breath tests for carbohydrate malabsorption require additional validated concurrent symptom evaluation to establish carbohydrate intolerance. Regarding the use of breath tests for the evaluation of oro‐cecal transit time and suspected small bowel bacterial overgrowth, this guideline highlights confounding factors associated with the interpretation of H2‐CH4‐breath tests in these indications and recommends approaches to mitigate these issues.ConclusionThis clinical practice guideline should facilitate pan‐European harmonization of diagnostic approaches to symptoms and disorders, which are very common in specialist and primary care gastroenterology practice, both in adult and pediatric patients. In addition, it identifies areas of future research needs to clarify diagnostic and therapeutic approaches.
Over‐the‐scope clip versus transcatheter arterial embolization for refractory peptic ulcer bleeding—A propensity score matched analysis
Authors: Kuellmer Armin , Mangold Tobias , Bettinger Dominik , Maruschke Lars , Wannhoff Andreas , Caca Karel , Wedi Edris , Hosseini Ali Seif Amir , Kleemann Tobias , Schulz Thomas , Jung Carlo , Thimme Robert , Schmidt Arthur 
Published: August 2021

AbstractBackgroundTranscatheter arterial embolization (TAE) or surgery are standard treatment of peptic ulcer bleeding (PUB) refractory to endoscopic hemostasis. Over‐the‐scope clips (OTSC) have shown superiority to standard endoscopic treatment.ObjectiveTo compare OTSC treatment to TAE in refractory peptic ulcer bleeding.Patients and MethodsIn this retrospective, multicenter study, 128 patients treated with OTSC (n = 66) or TAE (n = 62) for refractory PUB between 2009 and 2019 in four academic centers were analyzed. Primary endpoint was clinical success (hemostasis + no rebleeding within 7 days). Secondary endpoints were adverse events, length of ICU stay, and mortality. Propensity score matching was performed to adjust for differences in baseline characteristics.ResultsPatients characteristics were similar in both groups but ulcers in the TAE group were larger, more often located in the duodenal bulb (85.5% vs. 65.2%; p = 0.014), and that the proportion of Forrest Ia bleedings was higher (38.7% vs. 19.7%; p = 0.018). Clinical success was comparable in both groups (74.2% vs. 59.7%; p = 0.092). Stay on the intensive care unit (ICU) was significantly longer in the TAE group (mean 8.0 vs. 4.7 days; p = 0.002). Serious adverse events after re‐therapy (12.9% vs. 1.5%; p = 0.042) and in‐hospital mortality were significantly higher in the TAE group (9.1 vs. 22.6%, OR 2.92 [95% CI 1.04–8.16]; p = 0.05). After propensity score matching, the differences found regarding ICU stay (4.9± 5.9 and 9.2 ± 11.2; p = 0.009) and in‐hospital mortality (5% vs. 22.5%; OR 5.52 [95% CI: 1.11–27.43]; p = 0.048) stayed significant.ConclusionsOTSC treatment for refractory PUB was superior to TAE in terms of ICU stay and in‐hospital mortality.
Toxicity of fluoroquinolones on the cladoceran Daphnia magna
Authors: Eluk Dafna , Nagel Orlando , Gagneten Ana , Reno Ulises , Althaus Rafael 
Published: August 2021

AbstractThis study evaluates the acute and chronic toxicological effects of six fluoroquinolones on the mortality and growth of Daphnia magna. The NOECs calculated with the multivariate Probit regression model for the chronic study were 56 μg/L ciprofloxacin, 63 μg/L enrofloxacin, 78 μg/L levofloxacin, 85 μg/L marbofloxacin, 69 μg/L norfloxacin, and 141 μg/L ofloxacin. The risk quotients were determined using the measure environmental concentrations reported in water sources from different countries. The risks were low and moderate in water samples from rivers and lakes, although concentrations of ciprofloxacin, norfloxacin, and ofloxacin reported in some countries can cause toxicological damage to D. magna. In addition, urban wastewater and hospital wastewater samples constitute a threat to D. magna (high and moderate risks), requiring the treatment of these wastewater.Practitioner points

The NOECs calculated with the multivariate Probit model for the six fluoroquinolonas are between 56 μg/L ciprofloxacin and 141 μg/L ofloxacin.
The levels of ciprofloxacin, norfloxacin, and ofloxacin in urban wastewater and hospital wastewater produce moderate and high risks for D. magna.
Water and river samples from some countries containing ciprofloxacin, norlfoxacin, and ofloxacin present high risks for D. magna.
Experiencing Market Dynamics with TraderEx: A Trading Decision-Making Simulation
Authors: Ozenbas Deniz , Pagano Michael S. , Schwartz Robert A. , Weber Bruce W. 
Published: August 2021

AbstractTrading education is vital for success in the securities and investments industry. Are apprenticeships and time on an institutional trading desk the only way to learn how to trade? Do you need to work with real orders and have real money at risk to gain experience interacting with the dynamic process of price formation? The answers are no and no. Trading simulations that are well-designed can create experiences with price discovery and impose the challenges of illiquidity in ways that replicate the learning accomplished (and pressures felt) on a real trading desk. With TraderEx, you will appreciate the complexity of trading and understand it as a distinct profession within the financial industry, even if it is not always thought of as such in business school curriculum.
Dirichlet baths and the not-so-fine-grained Page curve
Authors: Ghosh Kausik , Krishnan Chethan 
Published: August 2021

Abstract
We present a doubly holographic prescription for computing entanglement entropy on a gravitating brane. It involves a Ryu-Takayanagi surface with a Dirichlet anchoring condition. In braneworld cosmology, a related approach was used previously in arXiv:2007.06551. There, the prescription naturally computed a co-moving entanglement entropy, and was argued to resolve the information paradox for a black hole living in the cosmology. In this paper, we show that the Dirichlet prescription leads to reasonable results, when applied to a recently studied wedge holography set up with a gravitating bath. The nature of the information paradox and its resolution in our Dirichlet problem have a natural understanding in terms of the strength of gravity on the two branes and at the anchoring location. By sliding the anchor to the defect, we demonstrate that the limit where gravity decouples from the anchor is continuous — in other words, as far as island physics is considered, weak gravity on the anchor is identical to no gravity. The weak and (moderately) strong gravity regions on the brane are separated by a “Dirichlet wall”. We find an intricate interplay between various extremal surfaces, with an island coming to the rescue whenever there is an information paradox. This is despite the presence of massless gravitons in the spectrum. The overall physics is consistent with the slogan that gravity becomes “more holographic”, as it gets stronger. Our observations strengthen the case that the conventional Page curve is indeed of significance, when discussing the information paradox in flat space. We work in high enough dimensions so that the graviton is non-trivial, and our results are in line with the previous discussions on gravitating baths in arXiv:2005.02993 and arXiv:2007.06551.
S-matrix bootstrap in 3+1 dimensions: regularization and dual convex problem
Authors: He Yifei , Kruczenski Martin 
Published: August 2021

Abstract
The S-matrix bootstrap maps out the space of S-matrices allowed by analyticity, crossing, unitarity, and other constraints. For the 2 → 2 scattering matrix S2→2 such space is an infinite dimensional convex space whose boundary can be determined by maximizing linear functionals. On the boundary interesting theories can be found, many times at vertices of the space. Here we consider 3 + 1 dimensional theories and focus on the equivalent dual convex minimization problem that provides strict upper bounds for the regularized primal problem and has interesting practical and physical advantages over the primal problem. Its variables are dual partial waves kℓ(s) that are free variables, namely they do not have to obey any crossing, unitarity or other constraints. Nevertheless they are directly related to the partial waves fℓ(s), for which all crossing, unitarity and symmetry properties result from the minimization. Numerically, it requires only a few dual partial waves, much as one wants to possibly match experimental results. We consider the case of scalar fields which is related to pion physics.
WDVV equations and invariant bi-Hamiltonian formalism
Authors: Vašíček J. , Vitolo R. 
Published: August 2021

Abstract
The purpose of the paper is to show that, in low dimensions, the WDVV equations are bi-Hamiltonian. The invariance of the bi-Hamiltonian formalism is proved for N = 3. More examples in higher dimensions show that the result might hold in general. The invariance group of the bi-Hamiltonian pairs that we find for WDVV equations is the group of projective transformations. The significance of projective invariance of WDVV equations is discussed in detail. The computer algebra programs that were used for calculations throughout the paper are provided in a GitHub repository.
Prophylaktische Fasziotomie bei Tibia-Osteotomien: funktionelle Ergebnisse
Authors: Degen Nikolaus , Randeu Tobias , Wolf Florian , Fürmetz Julian , Euler Ekkehard , Böcker Wolfgang , Thaller Peter Helmut 
Published: August 2021

Zusammenfassung
Hintergrund
Bei Tibia-Osteotomien (TO) mit Marknagelfixierung kann eine minimal-invasive, prophylaktische Fasziotomie (PF) der Extensorenloge zur Prävention eines postoperativen akuten Kompartmentsyndroms (KS) erfolgen. Bislang sind keine Studien über die Effekte von TO oder PF auf spezifische Funktionen der Extensoren bekannt.

Ziel der Arbeit
Die Untersuchung der Funktion nach PF und TO an Patient*innen ohne präoperative funktionelle Einschränkung.

Material und Methoden
In 41 Fällen (28 Frauen, 13 Männer) erfolgte durchschnittlich 6,1 Jahre nach elektiver TO mit PF und Marknagelfixierung eine Befragung zur klinischen Funktion. In 23 Fällen wurden die isometrische Kraft und der „range of motion“ (ROM) der Dorsalextension (DE) des oberen Sprunggelenks (OSG) gemessen. Die Kraft wurde als Test auf klinische Relevanz mit der 10 %-Normperzentile verglichen, sowie zur Gegenseite.

Ergebnisse
In durchschnittlich 86 % der Fälle wurde von keinen oder geringen funktionellen Einschränkungen der Extensoren berichtetet. Die mittlere Kraft zeigte keine signifikante Abweichung von der geschlechterspezifischen 10 %-Normperzentile, aber war im Seitenvergleich auf der operierten Seite mit 16,0 ± 6,5 kgf signifikant geringer als auf der Gegenseite mit 17,5 ± 6,3 kgf (p < 0,01). Die subjektive Einschränkung der DE im OSG korrelierte deutlich negativ mit der ROM (rs = −0,46, p < 0,05).

Diskussion
Die Ergebnisse lassen auf eine geringe Häufigkeit subjektiv relevanter funktioneller Einschränkungen der Extensoren schließen. Die vorgefundene Kraftminderung war nicht klinisch relevant. Subjektive Einschränkungen scheinen vorrangig durch Abnahme des ROM verursacht zu sein.
Spatio-temporal variation in number and production of neustonic and planktonic bacteria inhabiting polluted estuarine harbour channel
Authors: Perliński Piotr , Mudryk Zbigniew J. , Zdanowicz Marta , Kubera Łukasz 
Published: August 2021

AbstractThe aim of this paper was to determine the abundance and secondary production by bacteria inhabiting the surface microlayer and subsurface water in a specific water basin, i.e., polluted estuarine harbour channel. In a 3-year seasonal cycle, the total number of bacteria and their biomass were higher in the surface microlayer (SML) 7.57 × 108cells dm−3 and 15.86 µg C dm−3 than in the subsurface water (SSW) 4.25 × 108cells dm−3 and 9.11 µg C dm−3 of the studied channel. The opposite relationship was noted in the level of the secondary production (SML—37.16 μg C dm−3 h−1, SSW—60.26 μg C dm−3 h−1) in this water basin. According to the analysed microbiological parameters, the total number of bacteria and secondary production varied along the horizontal profile in the water of the studied channel. The total number of bacteria and their secondary production showed the seasonal variation as well.
Random inscribed polytopes in projective geometries
Authors: Besau Florian , Rosen Daniel , Thäle Christoph 
Published: August 2021

AbstractWe establish central limit theorems for natural volumes of random inscribed polytopes in projective Riemannian or Finsler geometries. In addition, normal approximation of dual volumes and the mean width of random polyhedral sets are obtained. We deduce these results by proving a general central limit theorem for the weighted volume of the convex hull of random points chosen from the boundary of a smooth convex body according to a positive and continuous density in Euclidean space. In the background are geometric estimates for weighted surface bodies and a Berry–Esseen bound for functionals of independent random variables.
Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests
Authors: Castelli Florence Anne , Rosati Giulio , Moguet Christian , Fuentes Celia , Marrugo-Ramírez Jose , Lefebvre Thibaud , Volland Hervé , Merkoçi Arben , Simon Stéphanie , Fenaille François , Junot Christophe 
Published: August 2021

AbstractMetabolomics refers to the large-scale detection, quantification, and analysis of small molecules (metabolites) in biological media. Although metabolomics, alone or combined with other omics data, has already demonstrated its relevance for patient stratification in the frame of research projects and clinical studies, much remains to be done to move this approach to the clinical practice. This is especially true in the perspective of being applied to personalized/precision medicine, which aims at stratifying patients according to their risk of developing diseases, and tailoring medical treatments of patients according to individual characteristics in order to improve their efficacy and limit their toxicity. In this review article, we discuss the main challenges linked to analytical chemistry that need to be addressed to foster the implementation of metabolomics in the clinics and the use of the data produced by this approach in personalized medicine. First of all, there are already well-known issues related to untargeted metabolomics workflows at the levels of data production (lack of standardization), metabolite identification (small proportion of annotated features and identified metabolites), and data processing (from automatic detection of features to multi-omic data integration) that hamper the inter-operability and reusability of metabolomics data. Furthermore, the outputs of metabolomics workflows are complex molecular signatures of few tens of metabolites, often with small abundance variations, and obtained with expensive laboratory equipment. It is thus necessary to simplify these molecular signatures so that they can be produced and used in the field. This last point, which is still poorly addressed by the metabolomics community, may be crucial in a near future with the increased availability of molecular signatures of medical relevance and the increased societal demand for participatory medicine.Graphical abstract
Effects of motor restrictions on preparatory brain activity
Authors: Sperl L. , Ruttloff J. M. , Ambrus G. G. , Kaufmann J. M. , Cañal-Bruland R. , Schweinberger S. R. 
Published: August 2021

AbstractModifying established motor skills is a challenging endeavor due to proactive interference from undesired old to desired new actions, calling for high levels of cognitive control. Motor restrictions may facilitate the modification of motor skills by rendering undesired responses physically impossible, thus reducing demands to response inhibition. Here we studied behavioral and EEG effects of rule changes to typing in skilled touch-typists. The respective rule change—typing without using the left index finger—was either implemented per instruction only or with an additional motor restriction. In both groups, the rule change elicited delays and more errors in typing, indicating the occurrence of proactive interference. While stimulus-locked ERPs did not exhibit prominent effects of rule change or group, response-locked ERPs revealed that the time courses of preparatory brain activity preceding typing responses depended on the presence of motor restriction. Although further research is necessary to corroborate our findings, they indicate a novel brain correlate that represents changes in inhibitory response preparation induced by short-term motor restrictions.
Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging
Authors: Li Yan , Vigneron Daniel B. , Xu Duan 
Published: August 2021

AbstractThe ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation.
Memristive devices based on mass printed organic resistive switching layers
Authors: Strutwolf Jörg , Chen Yong , Ullrich Johann , Dehnert Martin , Hübler Arved C. 
Published: August 2021

AbstractResistive random-access memory is a candidate for next-generation non-volatile memory architectures. In this study, we use flexographic roll-to-roll printing technology for deposition of the resistive layer, a printing method that allows fast and cost-effective fabrication to create non-volatile resistive memory devices. Metal-free organic polymers blends composed of poly(methyl methacrylate) (PMMA) and a surplus of poly(vinyl alcohol) (PVA) serve as the active layer. Microscopic studies of the roll-to-roll printed layers show circular domains of PMMA embedded in PVA. The influence of the PMMA content in the polymer blend is investigated with respect to the performance and reliability of the resistive memory cells. Electrical characterization reveals a retention time of at least eleven days, a Roff/Ron ratio of approx. two orders and write/erase voltages of + 1/−2 V.
Critical cluster composition from homogeneous nucleation data: application to water in carbon dioxide–nitrogen carrier gases
Authors: Campagna M. M. , Hrubý J. , van Dongen M. E. H. , Smeulders D. M. J. 
Published: August 2021

AbstractKnowledge on critical cluster composition is important for improving the nucleation theory. Thus, homogeneous water nucleation experiments previously carried out in nitrogen and 0%, 5%, 15% and 25% of carbon dioxide ( Campagna et al. 2020a, 2021) are analyzed. The tests were conducted at 240 K and 0.1 MPa, 1 MPa and 2 MPa. The observed nucleation rates are strongly dependent on supersaturation, pressure, temperature and mixture composition. These experimentally found dependencies can be used to derive the composition of critical clusters by means of the nucleation theorem. In this way, a macroscopic quantity, nucleation rate, reveals properties of critical clusters consisting of a few tens of molecules. Two novel methods are presented for the detailed application of the nucleation theorem. The first method extends to mixtures of $$\,\,\,\,\,\,\,N>2\,\,\,\,\,\,$$

N
>
2

components the approach used in literature for two components. The second method not only applies to $$N>2$$

N
>
2

mixtures in a more straightforward manner, but it can also be used for unary as well as for binary and multi-component nucleation cases. To the best of our knowledge, for the first time the critical cluster composition is computed for high pressure nucleation data of a vapor (here water) in mixtures of two carrier gases (here carbon dioxide–nitrogen). After a proper parameterization of the nucleation rate data, both methods consistently lead to the same critical nuclei compositions within the experimental uncertainty. Increasing pressure and carbon dioxide molar fraction at fixed supersaturation leads to a decrease in the water content of the critical cluster, while the adsorbed number of nitrogen and carbon dioxide molecules increases. As a consequence, the surface tension decreases. This outcome explains the observed increase in the nucleation rate with increasing pressure and carbon dioxide molar fraction at constant supersaturation.
Graphic abstract