bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcome of out-of-hospital vs. in-hospital cardiac arrest survivors presenting with ventricular tachyarrhythmias
Authors: Müller Julian , Behnes Michael , Schupp Tobias , Reiser Linda , Taton Gabriel , Reichelt Thomas , Ellguth Dominik , Borggrefe Martin , Engelke Niko , Bollow Armin , Kim Seung-Hyun , Weidner Kathrin , Ansari Uzair , Mashayekhi Kambis , Akin Muharrem , Halbfass Philipp , Meininghaus Dirk Große , Akin Ibrahim , Rusnak Jonas 
Published: November 2021

AbstractLimited data regarding the prognostic impact of ventricular tachyarrhythmias related to out-of-hospital (OHCA) compared to in-hospital cardiac arrest (IHCA) is available. A large retrospective single-center observational registry with all patients admitted due to ventricular tachyarrhythmias was used including all consecutive patients with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Survivors discharged after OHCA were compared to those after IHCA using multivariable Cox regression models and propensity-score matching for evaluation of the primary endpoint of long-term all-cause mortality at 2.5 years. Secondary endpoints were all-cause mortality at 6 months and cardiac rehospitalization at 2.5 years. From 2.422 consecutive patients with ventricular tachyarrhythmias, a total of 524 patients survived cardiac arrest and were discharged from hospital (OHCA 62%; IHCA 38%). In about 50% of all cases, acute myocardial infarction was the underlying disease leading to ventricular tachyarrhythmias with consecutive aborted cardiac arrest. Survivors of IHCA were associated with increased long-term all-cause mortality compared to OHCA even after multivariable adjustment (28% vs. 16%; log rank p = 0.001; HR 1.623; 95% CI 1.002–2.629; p = 0.049) and after propensity-score matching (28% vs. 19%; log rank p = 0.045). Rates of cardiac rehospitalization rates at 2.5 years were equally distributed between OHCA and IHCA survivors. In patients presenting with ventricular tachyarrhythmias, survivors of IHCA were associated with increased risk for all-cause mortality at 2.5 years compared to OHCA survivors.
Testimoniale Ungerechtigkeit gegenüber Menschen mit psychischer Erkrankung in der Gesundheitsversorgung. Eine konzeptionelle und ethische Analyse
Authors: Faissner Mirjam , Juckel Georg , Gather Jakov 
Published: November 2021

ZusammenfassungMenschen mit psychischer Erkrankung sterben statistisch gesehen früher als die Allgemeinbevölkerung. Ein Grund hierfür ist, dass sie eine schlechtere somatische Gesundheitsversorgung erhalten. Wir argumentieren, dass ableistische Netzwerke sozialer Bedeutung zu einer Abwertung der epistemischen Kompetenz von Menschen mit psychischer Erkrankung führen. Diese Abwertung kann mit dem Konzept der testimonialen Ungerechtigkeit erfasst werden. Testimoniale Ungerechtigkeit bezeichnet das ungerechtfertigte Herabstufen der Glaubwürdigkeit einer*s Sprecher*in aufgrund eines Vorurteils gegen ihre*seine soziale Identität. Wir analysieren ethische und epistemische Folgen testimonialer Ungerechtigkeit als wichtige Ursachen der schlechteren Gesundheitsversorgung von Menschen mit psychischer Erkrankung. Testimoniale Ungerechtigkeit kann zu medizinischen Behandlungsfehlern führen und für Betroffene schwerwiegende gesundheitliche Folgen nach sich ziehen. Zudem kann sie zu einem Vertrauensverlust von Menschen mit psychischer Erkrankung in das Gesundheitssystem führen. Daher trägt testimoniale Ungerechtigkeit zur strukturellen Diskriminierung von Menschen mit psychischer Erkrankung bei. Vor diesem Hintergrund diskutieren wir, wie die somatische Gesundheitsversorgung unter ethischen Gesichtspunkten verbessert werden kann.
An early intervention for adolescent depression targeting emotional mental images and memory specificity: a process evaluation
Authors: Pile Victoria , Schlepper Laura K. , Lau Jennifer Y. F. , Leamy Mary 
Published: November 2021

AbstractWe have evaluated a novel early intervention for adolescent depression (age 16–18) in a feasibility randomised controlled trial. This nested process evaluation aimed to understand how this complex intervention worked. We sought to understand participants’ views and experiences of receiving and interacting with the intervention to evaluate whether the underpinning theoretical basis of the intervention is justified and whether it contributes to valued outcomes for participants. Twelve participants were invited to take part in semi-structured interviews. Framework analysis was employed to identify important aspects of adolescents’ experiences. The active ingredients identified by participants were consistent with and extended our understanding of the theoretical basis of the intervention. Four principle themes were identified: understanding how memory works and being able to remember memories in more detail; processing negative experiences and letting go; imagining positive future events; and understanding and being kinder to myself. The outcomes of the intervention were valued by participants. Six principle themes were identified: improving mood and well-being; reducing impact of negative memories; motivation and goal-directed behaviour; overcoming avoidance and rumination; relationships, communication and being open; and self-understanding and acceptance. A simplified logic model is also proposed to connect the intervention components, active ingredients, and valued outcomes. The findings provide an in-depth understanding of how participants interacted with the intervention and what they derived from it. For example, the findings establish processing negative experiences as a core intervention component, extend it to include letting go of these memories, and highlight that reducing the impact of negative memories is valued by participants. This richer understanding guides further intervention development and future implementation.
Effects of B-azolemiteacrylic on life-history traits and demographic parameters of two-spotted spider mite, Tetranychus urticae (Acari: Tetranychidae)
Authors: Shang Suqin , Chang Yun , Li Wei-Zhen , Chang-Qing Wang , Peng-Cheng Nie 
Published: November 2021

AbstractThe present study was conducted to evaluate sublethal effects of B-azolemiteacrylic on the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae). Female adults of T. urticae were exposed to LC10 and LC30 of the acaricide, and the effects on treated females and their offspring were evaluated. The results showed that the fecundity of F0 female adults treated with LC10 and LC30 of B-azolemiteacrylic was reduced by 30.9 and 39.2%, respectively. Longevity and oviposition period of the females were significantly reduced as well. The developmental duration of egg and deutonymph stage of the F1 generation were not significantly different from that of the control. The protonymph stage after LC30 treatment lasted significantly longer, whereas the larva, deutonymph and female stage were significantly shorter than the control. The oviposition period of the F1 generation was significantly shortened, the fecundity of each female decreased significantly, and the ratio of female-to-male was reduced too. Moreover, the average generation period of T. urticae after LC10 and LC30 treatments was shorter than that of the control, and the net production rate (R0), intrinsic rate of increase (rm) and finite rate of increase (λ) were all reduced by 33.3, 7.5 and 1.9% (LC10 treatment) and by 51.3, 14.8 and 3.6% (LC30 treatment), respectively. The population doubling time was prolonged by 7.5 and 14.8% after LC10 and LC30 treatments, respectively, compared with the control. These results indicate that B-azolemiteacrylic may effectively inhibit the development rate of the F0 and F1 populations of T. urticae, which will help design integrated strategies for the comprehensive control of T. urticae and rational use of pesticides in the field.
Sexualized Drug Use Among Female Sex Workers from Eight Cities in China: A Cross-Sectional Study
Authors: Ong Jason J. , Xiong Mingzhou , Tucker Joseph D. , Wang Yajie , Smith M. Kumi , Tang Weiming , Fu Hongyun , Zheng Heping , Yang Bin , Wang Cheng 
Published: November 2021

AbstractThere is a rich literature on sexualized drug use (i.e., drug use before or during sex) for men who have sex with men but less data from female sex workers (FSW), particularly from low- and middle-income countries. We describe the sexual and reproductive health outcomes in FSW reporting sexualized drug use. In 2019, we conducted a cross-sectional study in eight cities from seven provinces in China. We recruited FSW through community organizations working with sex workers and included those aged 18 years or above, exchanged sex at least once for money or goods in the past three months, and had traded sex for longer than a year. Multivariable logistic regression models were used. In total, 650 women participated: average age was 38.8 years (SD 10.2), 57.1% reported a monthly income over 5000 RMB ($USD 707), and 12.8% completed high school or above. Among participants, 65 (10.0%, 95% confidence interval (CI) 7.8–12.6) reported a history of sexualized drug use. Compared to FSW who never reported a history of sexualized drug use, FSW who reported a history of sexualized drug use had greater odds of working for a manager compared to being self-employed (adjusted odds ratio (AOR) 4.04, 95% CI 2.12–7.69), work in a sauna (AOR 2.43, 95% CI 1.09–5.41), charging a higher price for vaginal sex (AOR 2.15, 95% CI 1.14–4.06), and ever diagnosed with STIs (AOR 4.51, 95% CI 2.61–7.80). One in ten FSW reported sexualized drug use. Although they had similar risk profiles in terms of consistency of condom use and reproductive health outcomes, these women were more likely to report past STIs than those who reported no sexualized drug use. Health workers who work with substance users should devote attention to the sexual practices of their clients to make sure that they have safer sex.
Climate Action for (My) Children
Authors: Fornwagner Helena , Hauser Oliver P. 
Published: November 2021

AbstractHow do we motivate cooperation across the generations—between parents and children? Here we study voluntary climate action (VCA), which is costly to today’s decision-makers but essential to enable sustainable living for future generations. We predict that “offspring observability” is critical: parents will be more likely to invest in VCA when their own offspring observes their action, whereas when adults or genetically unrelated children observe them, the effect will be smaller. In a large-scale lab-in-the-field experiment, we observe a remarkable magnitude of VCA: parents invest 82% of their 69€ endowment into VCA, resulting in almost 14,000 real trees being planted. Parents’ VCA varies across conditions, with the largest treatment effect occurring when a parent’s own child is the observer. In subgroup analyses, we find that larger treatment effects occur among parents with a high school diploma. Moreover, VCA for parents who believe in climate change is most affected by the presence of their own child. In contrast, VCA of climate change skeptical parents is most influenced by the presence of children to whom they are not related. Our findings have implications for policy-makers interested in designing programs to encourage voluntary climate action and sustaining intergenerational public goods.
Beyond Continuum Solvent Models in Computational Homogeneous Catalysis
Authors: Norjmaa Gantulga , Ujaque Gregori , Lledós Agustí 
Published: November 2021

AbstractIn homogeneous catalysis solvent is an inherent part of the catalytic system. As such, it must be considered in the computational modeling. The most common approach to include solvent effects in quantum mechanical calculations is by means of continuum solvent models. When they are properly used, average solvent effects are efficiently captured, mainly those related with solvent polarity. However, neglecting atomistic description of solvent molecules has its limitations, and continuum solvent models all alone cannot be applied to whatever situation. In many cases, inclusion of explicit solvent molecules in the quantum mechanical description of the system is mandatory. The purpose of this article is to highlight through selected examples what are the reasons that urge to go beyond the continuum models to the employment of micro-solvated (cluster-continuum) of fully explicit solvent models, in this way setting the limits of continuum solvent models in computational homogeneous catalysis. These examples showcase that inclusion of solvent molecules in the calculation not only can improve the description of already known mechanisms but can yield new mechanistic views of a reaction. With the aim of systematizing the use of explicit solvent models, after discussing the success and limitations of continuum solvent models, issues related with solvent coordination and solvent dynamics, solvent effects in reactions involving small, charged species, as well as reactions in protic solvents and the role of solvent as reagent itself are successively considered.
Visualizing CAR-T cell Immunotherapy Using 3 Tesla Fluorine-19 MRI
Authors: Dubois Veronica P. , Sehl Olivia C. , Foster Paula J. , Ronald John A. 
Published: November 2021

Abstract
Purpose
Chimeric antigen receptor (CAR) T cell cancer immunotherapies have shown remarkable results in patients with hematological malignancies and represent the first approved genetically modified cellular therapies. However, not all blood cancer patients respond favorably, serious side effects have been reported, and the treatment of solid tumors has been a challenge. An imaging tool for visualizing the variety of CAR-T cell products in use and being explored could provide important patient-specific data on CAR-T cell location to inform on potential success or failure of treatment as well as off-target toxicities. Fluorine-19 (19F) magnetic resonance imaging (MRI) allows for the noninvasive detection of 19F perfluorocarbon (PFC) labeled cells. Our objective was to visualize PFC-labeled (PFC +) CAR-T cells in a mouse model of leukemia using clinical field strength (3 Tesla) 19F MRI and compare the cytotoxicity of PFC + versus unlabeled CAR-T cells.

Procedures
NSG mice (n = 17) received subcutaneous injections of CD19 + human B cell leukemia cells (NALM6) expressing firefly luciferase in their left hind flank (1 × 106). Twenty-one days later, each mouse received an intratumoral injection of 10 × 106 PFC + CD19-targeted CAR-T cells (n = 6), unlabeled CD19-targeted CAR-T cells (n = 3), PFC + untransduced T cells (n = 5), or an equivalent volume of saline (n = 3). 19F MRI was performed on mice treated with PFC + CAR-T cells days 1, 3, and 7 post-treatment. Bioluminescence imaging (BLI) was performed on all mice days − 1, 5, 10, and 14 post-treatment to monitor tumor response.

Results
PFC + CAR-T cells were successfully detected in tumors using 19F MRI on days 1, 3, and 7 post-injection. In vivo BLI data revealed that mice treated with PFC + or PFC − CAR-T cells had significantly lower tumor burden by day 14 compared to untreated mice and mice treated with PFC + untransduced T cells (p < 0.05). Importantly, mice treated with PFC + CAR-T cells showed equivalent cytotoxicity compared to mice receiving PFC − CAR-T cells.

Conclusions
Our studies demonstrate that clinical field strength 19F MRI can be used to visualize PFC + CAR-T cells for up to 7 days post–intratumoral injection. Importantly, PFC labeling did not significantly affect in vivo CAR-T cell cytotoxicity. These imaging tools may have broad applications for tracking emerging CAR-T cell therapies in preclinical models and may eventually be useful for the detection of CAR-T cells in patients where localized injection of CAR-T cells is being pursued.
Acute Stroke Treatment in an Anticoagulated Patient: When Is Thrombolysis an Option?
Authors: Siller Teresa , Chandratheva Arvind , Bücke Philipp , Werring David J. , Seiffge David 
Published: November 2021

Abstract
Purpose of Review
Direct oral anticoagulants (DOACs: the factor Xa inhibitors rivaroxaban, apixaban, and edoxaban and the direct thrombin inhibitor dabigatran) are the mainstay of stroke prevention in patients with non-valvular atrial fibrillation (AF). Nevertheless, there is a residual stroke risk of 1–2% per year despite DOAC therapy. Intravenous thrombolysis (IVT) reduces morbidity in patients with ischemic stroke and improves functional outcome. Prior DOAC therapy is a (relative) contraindication for IVT but emerging evidence supports its use in selected patients.

Recent Findings
Recent observational studies highlighted that IVT in patients on prior DOAC therapy seems feasible and did not yield major safety issues. Different selection criteria and approaches have been studied including selection by DOAC plasma levels, non-specific coagulation assays, time since last intake, and prior reversal agent use. The optimal selection process is however not clear and most studies comprised few patients.

Summary
IVT in patients taking DOAC is a clinically challenging scenario. Several approaches have been proposed without major safety issues but current evidence is weak. A patient-oriented approach balancing potential benefits of IVT (i.e., amount of salvageable penumbra) against expected bleeding risk including appropriate monitoring of anticoagulant activity seem justified.
“I Have Been Born, Raised and Lived My Whole Life Here” – Perpetually on the Move While Remaining Still
Authors: Pedersen Oliver Clifford , Zittoun Tania 
Published: November 2021

AbstractThis article explores the story of Einar, a Faroese man who always lived within a 500-meters radius on the island of Suðuroy, who never felt “stuck” or “immobile” in the literal sense of the word. Studies have shown that staying is a process, as much as mobility; yet while mobility studies mainly show that imagination is an incentive to move, we argue that imagination may also actively support staying. Combining sociocultural psychology with mobility studies, we propose to explore the entanglement of symbolic mobility (a form of imagination) and various forms of geographical (im)mobility. Based on ethnographic fieldwork and hours of conversation, we present the case study of Einar’s life on his island. We follow the sociogenetic development of the island, and the expansion and contraction of the imaginative horizon over time. On this background, we then retrace the life of Einar and show how, within this transforming context, his imagination developed thanks to resources he could use from the mobility of technologies, ideas, and other people. Interestingly, at different bifurcation points, his symbolic mobility almost led him to move away but, at another point, helped him to refuse geographical mobility. Hence, he was always symbolically mobile while staying. We finally propose directions for generalising from this case study, and implications for cultural psychology and for mobility and migration studies.
Detecting Lies is a Child (Robot)’s Play: Gaze-Based Lie Detection in HRI
Authors: Pasquali Dario , Gonzalez-Billandon Jonas , Aroyo Alexander Mois , Sandini Giulio , Sciutti Alessandra , Rea Francesco 
Published: November 2021

AbstractRobots destined to tasks like teaching or caregiving have to build a long-lasting social rapport with their human partners. This requires, from the robot side, to be capable of assessing whether the partner is trustworthy. To this aim a robot should be able to assess whether someone is lying or not, while preserving the pleasantness of the social interaction. We present an approach to promptly detect lies based on the pupil dilation, as intrinsic marker of the lie-associated cognitive load that can be applied in an ecological human–robot interaction, autonomously led by a robot. We demonstrated the validity of the approach with an experiment, in which the iCub humanoid robot engages the human partner by playing the role of a magician in a card game and detects in real-time the partner deceptive behavior. On top of that, we show how the robot can leverage on the gained knowledge about the deceptive behavior of each human partner, to better detect subsequent lies of that individual. Also, we explore whether machine learning models could improve lie detection performances for both known individuals (within-participants) over multiple interaction with the same partner, and with novel partners (between-participant). The proposed setup, interaction and models enable iCub to understand when its partners are lying, which is a fundamental skill for evaluating their trustworthiness and hence improving social human–robot interaction.
The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma
Authors: Yu Yue , Shen Liangliang , Xie Xiaoyun , Zhao Jingjun , Jiang Miao 
Published: November 2021

Abstract
Background:
Scleroderma is a multisystem disease in which tissue fibrosis is caused by inflammation and vascular damage. The mortality of scleroderma has remained high due to a lack of effective treatments. However, exosomes derived from human umbilical cord mesenchymal stem cells (HUMSCs)-Ex have been regarded as potential treatments for various autoimmune diseases, and may also act as candidates for treating scleroderma.

Methods:
Mice with scleroderma received a single 50 μg HUMSCs-Ex. HUMSCs-Ex was characterized using transmission electron microscopy, nanoparticle tracking analysis and nanoflow cytometry. The therapeutic efficacy was assessed using histopathology, immunohistochemistry, immunofluorescence, quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay and western blot.

Results:
HUMSCs-Ex ameliorated the deposition of extracellular matrix and suppressed the epithelial-mesenchymal transition process, and the effects lasted at least three weeks. In addition, HUMSCs-Ex promoted M1 macrophage polarization and inhibited M2 macrophage polarization, leading to the restoration of the balance of M1/M2 macrophages.

Conclusion:
We investigated the potential antifibrotic and anti-inflammatory effects of HUMSCs-Ex in a bleomycin-induced mouse model of scleroderma. So HUMSCs-Ex could be considered as a candidate therapy for scleroderma.
Proceedings of the Joint Discussion: Radar Determinations of Planetary Motions
Authors: Shapiro I. I. 
Published: November 2021

AbstractRadar echoes have already been detected from Venus, Mercury, Mars, and Jupiter. Time delay measurements of high precision between Earth and Venus, as well as between Earth and Mercury, have disclosed significant deviations from the published ephemerides of these planets. Although new simultaneous solutions for the A.U., the relevant planetary masses, radii, and orbital elements have not yet been carried out, preliminary analysis indicates that the light-second equivalent of the A.U. is 499.0050 ± 0.0004 and that the corresponding kilometer equivalent is about 149 598 000 ± 100 (using c = 299 792.5 km/sec). The same analysis shows that, with respect to Earth, both Venus and Mercury seem to be ahead in their orbits relative to predictions. The radius of Venus appears to be about 6100 ± 50 km, in agreement with the most accurate optical determination. Doppler spread measurements show Venus to have a retrograde rotation with a period of about 247 ± 5 days. The celestial latitude of its axis is about – 85 ± 2 degrees.