bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictability of U.S. Regional Extreme Precipitation Occurrence Based on Large-Scale Meteorological Patterns (LSMPs)
Authors: Gao Xiang , Mathur Shray 
Published: May 2021

AbstractIn this study, we use analogue method and Convolutional Neural Networks (CNNs) to assess the potential predictability of extreme precipitation occurrence based on Large-Scale Meteorological Patterns (LSMPs) for the winter (DJF) of Pacific Coast California (PCCA) and the summer (JJA) of Midwestern United States (MWST). We evaluate the LSMPs constructed with a large set of variables at multiple atmospheric levels and quantify the prediction skill with a variety of complementary performance measures. Our results suggest that LSMPs provide useful predictability of daily extreme precipitation occurrence and its interannual variability over both regions. The 14-year (2006-2019) independent forecast shows Gilbert Skill Scores (GSS) in PCCA range from 0.06 to 0.32 across 24 CNN schemes and from 0.16 to 0.26 across 4 analogue schemes, in contrast to those from 0.1 to 0.24 and from 0.1 to 0.14 in MWST. Overall, CNN is shown to be more powerful in extracting the relevant features associated with extreme precipitation from the LSMPs than analogue method, with several single-variate CNN schemes achieving more skillful prediction than the best multi-variate analogue scheme in PCCA and more than half of CNN schemes in MWST. Nevertheless, both methods highlight the Integrated Vapor Transport (IVT, or its zonal and meridional components) enables higher skills than other atmospheric variables over both regions. Warm-season extreme precipitation in MWST presents a forecast challenge with overall lower prediction skill than in PCCA, attributed to the weak synoptic-scale forcing in summer.
Development of Convective-Scale Static Background Error Covariance within GSI-Based Hybrid EnVar System for Direct Radar Reflectivity Data Assimilation
Authors: Wang Yongming , Wang Xuguang 
Published: May 2021

AbstractA convective-scale static background-error covariance (BEC) matrix is further developed to include the capability of direct reflectivity assimilation and evaluated within the GSI-based three-dimensional variational (3DVar) and hybrid ensemble–variational (EnVar) methods. Specific developments are summarized as follows: 1) Control variables (CVs) are extended to include reflectivity, vertical velocity, and all hydrometeor types. Various horizontal momentum and moisture CV options are included. 2) Cross correlations between all CVs are established. 3) A storm intensity-dependent binning method is adopted to separately calculate static error matrices for clear-air and storms with varying intensities. The resultant static BEC matrices are simultaneously applied at proper locations guided by the observed reflectivity. 4) The EnVar is extended to adaptively incorporate static BECs based on the quality of ensemble covariances. Evaluation and examination of the new static BECs are first performed on the 8 May 2003 Oklahoma City supercell. Detailed diagnostics and 3DVar examinations suggest zonal/meridional winds and pseudo–relative humidity are selected as horizontal momentum and moisture CVs for direct reflectivity assimilation, respectively; inclusion of cross correlations favors spin up and maintains the analyzed storms; application of binning improves characteristics and persistence of the simulated storm. Relative to an experiment using the full ensemble BECs (Exp-PureEnVar), incorporating static BECs in hybrid EnVar reduces spinup time and better analyzes reflectivity distributions while the background ensemble is deficient in sampling errors. Compared to both pure 3DVar and Exp-PureEnVar, hybrid EnVar better predicts reflectivity distributions and better maintains a strong mesocyclone. Further examination through the 20 May 2013 Oklahoma supercells confirms these results and additionally demonstrates the effectiveness of adaptive hybridization.
The relationship between psychological distress and impairment of disease-specific quality-of-life compared between liquid sclerocompression therapy and invasive treatments in patients with superficial venous disease during a one-year follow-up
Authors: Krasznai Attila G , Catarinella Fabio S , Houtermans-Auckel Janine , Nieman FHM , Wittens IAJ , Mooij MC , Wittens Cees HA 
Published: May 2021

Introduction Superficial venous disease (SVD) is a very common disease and much research has been done towards finding the ideal treatment and discovering the pathophysiology of SVD. Not much is known about the psychological burden of SVD. Current guidelines and scientific publications tend to focus on clinical and physiological aspects of SVD. The aim of this study was to relate the changes in Quality-of-Life (QoL) after SVD treatment to possible changes in psychological distress (PD). Methods A prospective cohort was set up with the assistance of 5 specialized vein clinics in the Netherlands. Inclusion criteria were: 18 years of age or older, fluent in Dutch language, C1 to C6 (CEAP) class intended to be primary treated with either endovenous laser(LA), radiofrequency ablation (RFA) and phlebectomy(PHL) or sclerocompression therapy alone (SCT). Patients were divided in two groups: 1. C1-C3 patients treated by SCT 2. C1-C6 patients treated invasively (LA, RFA and PHL) Outcomes were a disease specific QoL questionnaire (CIVIQ-20) and a questionnaire to assess PD (Hospital Anxiety and Depression Scales (HADS)). This study was approved by the local institutional review board, following the principles outlines in the Declaration to Helsinki. This trial was registered in the ISRCTN registry with study ID ISRCTN12085308 Results 442 patients were included in the study and completed the T0 measurements. Mean age of these patients is 54.4 years (s.d. 12.9, 17-90). Number of females: 349 (79.0%), of males: 93 (21.0%). The mean baseline (T-0) HADS depression (0-3) scale scores is 2.54 (s.d. 0.51, n = 412). The mean one-year difference between T-12 HADS depression (0-3) scale scores and baseline T-0 scores is +0.06. The mean baseline (T-0) HADS anxiety (0-3) scale scores is 2.19 (s.d. 0.5, n = 283). The mean one-year difference between T-12 HADS anxiety (0-3) scale scores and baseline T-0 scores is +0.06. Controlled for baseline scores, gender, age, weight and length(BMI), patients in group 2 (receiving invasive treatment) show significantly higher one-year improvement in the QoL of their psychological state of mind than patients in group 1 (receiving SCT and having C1,2,3) (beta 0.158 p = 0.002). Conclusions The significant improvement in psychological, QoL and clinical scores that we observe after successful invasive treatment compared to no significant improvement after SCT and the lack of psychological distress in patients with “simple” SVD indicates that SCT is mainly performed for cosmetic reasons. One could thus argue that reimbursement of SCT as a stand-alone medical treatment is debatable.
Is Dementia-Specific Caregiving Compared With Non-Dementia Caregiving Associated With Physical Difficulty Among Caregivers for Community-Dwelling Adults?
Authors: Parker Lauren J. , Fabius Chanee , Rivers Emerald , Taylor Janiece L. 
Published: May 2021

Objective: The purpose of this study is to identify whether dementia caregiving is associated with physical difficulty among informal caregivers. Methods: This cross-sectional retrospective cohort study design used data from the 2015 National Health and Aging Trends Study and the National Study of Caregiving. Binary logistic regression was used to examine the association between substantial physical difficulty and dementia caregiving among 1,871 caregivers. Results: Nearly 14% of the caregivers reported substantial physical difficulty. Dementia caregivers were 1.5 times more likely to report caregiving-related substantial physical difficulty (adjusted odds ratio [AOR] = 1.58, p = .04) than non-dementia caregivers. Factors associated with substantial physical difficulty included caregiver gender, self-rated health, depressive symptoms, pain, and caring for someone receiving assistance with three or more self-care or mobility activities. Discussion: Future studies should identify strategies to mitigate the physical demands on dementia caregivers. Early monitoring of caregivers’ self-rated health, depressive symptoms, and pain may identify those more likely to experience physical difficulty.
Interventions to Improve Medication Adherence in Ethnically Diverse Patients: A Narrative Systematic Review
Authors: Singh Pavneet , LeBlanc Pamela , King-Shier Kathryn 
Published: May 2021

Introduction: Ethnically diverse patients often have lower medication adherence relative to Whites. Certain ethnic groups are also more susceptible to cardiovascular and related diseases. It is critical to develop culturally tailored interventions to improve medication adherence in these ethnically diverse patients. Thus, the aim of this systematic review was to identify what interventions have been developed and tested to improve medication adherence in ethnically diverse patients with cardiovascular-related diseases. Method: A systematic search of peer-reviewed literature (MEDLINE, Cumulative Index to Nursing and Allied Health Literature, EMBASE, and Cochrane Central Register of Controlled Trials) was conducted to identify relevant articles. The narrative synthesis was performed based on elements offered by Popay et al. The mixed methods appraisal tool was used to appraise the quality of the included studies. Results: A total of 11,294 records were retrieved, and 34 articles met the inclusion criteria for this systematic review. Synthesis of the literature revealed four overarching intervention strategies used to improve medication adherence: pharmacist-mediated, primarily nurse-led, community-based and community-health worker led, and text-message and phone-based. Discussion: Several approaches can be used to improve medication adherence in ethnically diverse patients, although details on the approaches and conditions to produce optimal improvements for particular ethnic groups need to be determined in future studies. How does this affect culturally congruent health care?
Forecasting Posttreatment Outcome of Hallux Valgus Surgery Patients
Authors: Sawah Amjad , Zemenova Stepanka , Haque Russel , Ridley David , Abboud Rami J. , Wang Weijie , Harrold Fraser 
Published: May 2021

Background: Despite advancements in operative techniques and the extraordinary number of procedures described for correcting hallux valgus (HV), there is still uncertainty as to why some patients thrive postoperatively whereas others do not. This study aimed to investigate whether the postoperative outcome of HV surgery could be predicted from patient demographics or functional impairment at the time of referral. Methods: The prospectively collected data, from 92 patients, were analyzed to determine whether patient demographics significantly influenced outcome 52 weeks after surgery. Potential relationships between socioeconomic deprivation and the outcome, as well as between preoperative functional impairment and postoperative improvement, were examined. The Manchester Oxford Foot Questionnaire (MOXFQ) and Scottish Index of Multiple Deprivation (SIMD) were used in this evaluation. Results: None of the demographics studied were found to be statistically significant determinants of outcome. Preoperative MOXFQ scores for patients from the most deprived areas were significantly worse at the time of referral. Patients living in the least deprived postcodes experienced the lowest improvement in MOXFQ scores. Patients from the most deprived SIMD quintile achieved significantly higher improvement in MOXFQ–walking and standing compared to those from the least deprived quintile. A strong positive correlation was found between the preoperative MOXFQ scores and the improvement in the scores postoperatively. Conclusion: In this patient cohort, demographics could not be used to predict the postoperative outcome at week 52. Socioeconomic disparities seem to influence the timing of patients seeking surgery. Lower preoperative MOXFQ scores strongly correlate with a lesser degree of postoperative improvement. Level of Evidence: Level III, retrospective study with prospective arm.
Pulmonary arterial hypertension associated with congenital heart disease: lessons learnt from the large Turkish Nationwide Registry (THALES)
Authors: Kücükoglu Serdar M. , Kaymaz Cihangir , Alehan Dursun , Kula Serdar , Akcevin Atıf , Celiker Alpay , Cicek Sertac M. , Tokgözoglu Lale S. , Kentli Suleyman ,   THALES Registry Investigators
Published: May 2021

Pulmonary hypertension is a group of diseases, including pulmonary arterial hypertension associated with congenital heart disease (APAH‐CHD), characterized by progressive deterioration in pulmonary hemodynamics associated with substantial morbidity and mortality risk. THALES is a national multicenter, prospective observational registry, providing data on patients with APAH‐CHD. The study comprised APAH‐CHD patients (>3 months of age) with confirmed diagnosis of right heart catheterization or echocardiographic findings. Initial and follow‐up data were collected via regular hospital visits. Descriptive statistics are used for definitive purposes. Overall, 1034 patients aged 3 months–79 years (median 11.2 [Q1–Q3: 2.2–24.3] years) with APAH‐CHD were enrolled at 61 centers, 50.3% being retrospectively enrolled. Most had either Eisenmenger's syndrome (49.2%) or systemic‐to‐pulmonary shunts (42.7%). Patients were mostly in functional class I–II at the time of diagnosis (46.6%). Mean 6‐min walk distance (6MWD) was 369 ± 120 m. Mean pulmonary arterial pressure was 54.7 ± 22.2 mmHg for the whole group, and was highest in patients with Eisenmenger's syndrome. Targeted therapies were noted in 398 (38.5%) patients (monotherapy in 80.4%). Follow‐up data were available in 506 patients. Survival at 140 months was 79% and was associated with baseline 6MWD >440 m (p = 0.009), brain natriuretic peptide level < 300 ng/L (p < 0.001). Follow‐up 6MWD >165 m (p < 0.0001), brain natriuretic peptide level <300 ng/L (p = 0.031), and targeted therapies (p = 0.004) were also predictive of survival. THALES is the largest registry dedicated to APAH‐CHD to date and provides important contributions on demographics, clinical characteristics, and gaps in disease management.
Utilization of partograph and its associated factors among obstetric caregivers in public health institutions of Southwest Ethiopia
Authors: Tilahun Abel Girma , Gebeyehu Dawit Getachew , Adinew Yayehyirad Yemaneh , Mengstu Fekede Woldekidan 
Published: May 2021

Abstract
Background
Partographs should be used universally to monitor the mother and fetus’s conditions during delivery. However, its application in different parts of the world, including Ethiopia, is inconsistent. Moreover, its magnitude has not been determined in study area. As a result, the aim of this study was to investigate the utilization of partograph and associated factors among obstetric caregivers in public health institutions of Southwest Ethiopian.

Methods
An institutional-based cross-sectional study was conducted in Southwest Ethiopia from March 1st to June 30th, 2018. A simple random sampling technique was used to select study participants. A self-administered questionnaire was used to gather data on background characteristics, knowledge of partograph, and partograph utilization. The collected data were entered into an EPI Info and analysed using SPSS Version 22. We used bivariate and multivariate logistic regression analysis. Frequencies, tables, and graphs were used to present the final results. To determine statistical significance, a P-value of less than 0.05 was used.

Result
The response rate of this study was 393(92.2 %). The magnitude of utilization of partograph was 43 % with (95 % CI: 38.4, 48.1). According to the multivariate analysis being nurse or health officer [AOR = 0.37(0.21, 0.66)], degree level educational qualification [AOR = 0.32 (0.17, 0.60)], being trainined on partograph [Adjusted OR = 7.83 (95 % CI: (4.54, 13.50)], good knowledge about partograph [AOR = 5.84 (95 % CI: (3.27, 10.44)] and working at health center [AOR = 1.99 (95 % CI: (1.12, 3.52)] were found as determinants of partograph utilization.

Conclusions
The magnitude of partograph utilization among obstetric caregivers was found to be low in this study. Partograph utilization was determined by the type of profession, qualification level, knowledge of partograph, in-service training, and type of institution. To ensure its regular, obstetric caregivers must receive training and gain knowledge about it.
Relationships between age at first substance use and persistence of cannabis use and cannabis use disorder
Authors: Millar Seán R. , Mongan Deirdre , Smyth Bobby P. , Perry Ivan J. , Galvin Brian 
Published: May 2021

Abstract
Background
From a secondary prevention perspective, it is useful to know who is at greatest risk of progressing from substance initiation to riskier patterns of future use. Therefore, the aim of this study was to determine relationships between age at first use of alcohol, tobacco and cannabis and patterns of cannabis use, frequency of use and whether age of substance use onset is related to having a cannabis use disorder (CUD).

Methods
We analysed data from Ireland’s 2010/11 and 2014/15 National Drug Prevalence Surveys, which recruited 5134 and 7005 individuals respectively, aged 15 years and over, living in private households. We included only those people who reported lifetime cannabis use. Multinomial, linear and binary logistic regression analyses were used to determine relationships between age of substance use onset and patterns of cannabis use, frequency of use and having a CUD.

Results
When compared to former users, the odds of being a current cannabis user were found to be reduced by 11% (OR = 0.89; 95% CI: 0.83, 0.95) and 4% (OR = 0.96; 95% CI: 0.92, 1.00) for each year of delayed alcohol and cannabis use onset, respectively. Among current users, significant inverse linear relationships were noted, with increasing age of first use of tobacco (β = − 0.547; P < .001) and cannabis (β = − 0.634; P < .001) being associated with a decreased frequency of cannabis use within the last 30 days. The odds of having a CUD were found to be reduced by 14% (OR = 0.86; 95% CI: 0.78, 0.94) and 11% (OR = 0.89; 95% CI: 0.82, 0.98) for each year of delayed tobacco and cannabis use onset respectively in analyses which examined survey participants aged 15–34 years.

Conclusions
Among people who report past cannabis use, it is those with a more precocious pattern of early use of substances, including alcohol, and especially tobacco and cannabis, who are more likely to report ongoing, heavy and problematic cannabis use. Secondary prevention initiatives should prioritise people with a pattern of very early onset substance use.
Hyperlactatemia associated with diabetic ketoacidosis in pediatric intensive care unit
Authors: Liu Jingwei , Yan Haibo , Li Yumei 
Published: May 2021

Abstract
Background
Children with diabetic ketoacidosis often have elevated lactate. In this study, we investigated the clinical variables associated with hyperlactatemia in children with diabetic ketoacidosis.

Methods
We designed a single-center retrospective descriptive study of children with diabetic ketoacidosis in a pediatric intensive care unit.

Results
Of the 107 patients with diabetic ketoacidosis included in the analysis, 61 developed hyperlactatemia. Multivariate logistic regression analysis showed that heart rate (p = 0.003),diastolic blood pressure (p = 0.001) and stage of severity (p = 0.042) were independently associated with the development of hyperlactatemia in diabetic ketoacidosis. We found that lactate level was not significantly associated with length of hospital stay (p = 0.115) or the length of time to diabetic ketoacidosis resolution (p = 0.143).

Conclusions
Children with diabetic ketoacidosis presenting with severer stage, elevated heart rate and higher diastolic blood pressure may be prone to hyperlactatemia. Hyperlactatemia was not associated with length of time to DKA resolution and length of hospital stay.
The definition of major trauma using different revisions of the abbreviated injury scale
Authors:   Dutch Trauma Registry Southwest, Van Ditshuizen Jan C. , Sewalt Charlie A. , Palmer Cameron S. , Van Lieshout Esther M. M. , Verhofstad Michiel H. J. , Den Hartog Dennis 
Published: May 2021

Abstract
Background
A threshold Injury Severity Score (ISS) ≥ 16 is common in classifying major trauma (MT), although the Abbreviated Injury Scale (AIS) has been extensively revised over time. The aim of this study was to determine effects of different AIS revisions (1998, 2008 and 2015) on clinical outcome measures.

Methods
A retrospective observational cohort study including all primary admitted trauma patients was performed (in 2013–2014 AIS98 was used, in 2015–2016 AIS08, AIS08 mapped to AIS15). Different ISS thresholds for MT and their corresponding observed mortality and intensive care (ICU) admission rates were compared between AIS98, AIS08, and AIS15 with Chi-square tests and logistic regression models.

Results
Thirty-nine thousand three hundred seventeen patients were included. Thresholds ISS08 ≥ 11 and ISS15 ≥ 12 were similar to a threshold ISS98 ≥ 16 for in-hospital mortality (12.9, 12.9, 13.1% respectively) and ICU admission (46.7, 46.2, 46.8% respectively). AIS98 and AIS08 differed significantly for in-hospital mortality in ISS 4–8 (χ2 = 9.926, p = 0.007), ISS 9–11 (χ2 = 13.541, p = 0.001), ISS 25–40 (χ2 = 13.905, p = 0.001) and ISS 41–75 (χ2 = 7.217, p = 0.027). Mortality risks did not differ significantly between AIS08 and AIS15.

Conclusion
ISS08 ≥ 11 and ISS15 ≥ 12 perform similarly to a threshold ISS98 ≥ 16 for in-hospital mortality and ICU admission. This confirms studies evaluating mapped datasets, and is the first to present an evaluation of implementation of AIS15 on registry datasets. Defining MT using appropriate ISS thresholds is important for quality indicators, comparing datasets and adjusting for injury severity.

Level of evidence
Prognostic and epidemiological, level III.
Chimeric HP-PRRSV2 containing an ORF2-6 consensus sequence induces antibodies with broadly neutralizing activity and confers cross protection against virulent NADC30-like isolate
Authors: Chen Nanhua , Li Shubin , Tian Yunfei , Li Xinshuai , Li Shuai , Li Jixiang , Qiu Ming , Sun Zhe , Xiao Yanzhao , Yan Xilin , Lin Hong , Yu Xiuling , Tian Kegong , Shang Shaobin , Zhu Jianzhong 
Published: May 2021

AbstractDue to the substantial genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV), commercial PRRS vaccines fail to provide sufficient cross protection. Previous studies have confirmed the existence of PRRSV broadly neutralizing antibodies (bnAbs). However, bnAbs are rarely induced by either natural infection or vaccination. In this study, we designed and synthesized a consensus sequence of PRRSV2 ORF2-6 genes (ORF2-6-CON) encoding all envelope proteins based on 30 representative Chinese PRRSV isolates. The ORF2-6-CON sequence shared > 90% nucleotide identities to all four lineages of PRRSV2 isolates in China. A chimeric virus (rJS-ORF2-6-CON) containing the ORF2-6-CON was generated using the avirulent HP-PRRSV2 JSTZ1712-12 infectious clone as a backbone. The rJS-ORF2-6-CON has similar replication efficiency as the backbone virus in vitro. Furthermore, pig inoculation and challenge studies showed that rJS-ORF2-6-CON is not pathogenic to piglets and confers better cross protection against the virulent NADC30-like isolate than a commercial HP-PRRS modified live virus (MLV) vaccine. Noticeably, the rJS-ORF2-6-CON strain could induce bnAbs while the MLV strain only induced homologous nAbs. In addition, the lineages of VDJ repertoires potentially associated with distinct nAbs were also characterized. Overall, our results demonstrate that rJS-ORF2-6-CON is a promising candidate for the development of a PRRS genetic engineered vaccine conferring cross protection.