bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYULUHAN TENTANG DIARE DI SMA N 2 KUMAI
Authors: Supriyatna Yayat 
Published: November 2021

Penyakit diare masih merupakan masalah kesehatan masyarakat di negara berkembang seperti di Indonesia. Berdasarkan riset yang dilakukan oleh Departemen Kesehatan RI pada tahun 2007, diare menduduki peringkat ketigabelas sebagai penyebab kematian semua umur dengan proporsi sebesar 3,5 persen. Sedangkan berdasarkan kategori penyakit menular, diare menduduki urutan ketiga penyebab kematian setelah Pneumonia dan TBC. Penyebab utama kematian akibat diare adalah tata laksana yang tidak tepat baik di rumah maupun di sarana kesehatan. Untuk menurunkan kematian karena diare perlu tata laksana yang cepat dan tepat. Diare dapat berakibat fatal apabila penderita mengalami dehidrasi akibat kehilangan banyak cairan dari tubuh Kata Kunci : Penyuluhan, Diare
HUBUNGAN PENGETAHUAN PERAWAT DENGAN PENERAPAN METODE KEPERAWATAN TIM PRIMER DI RUANG RAWAT INAP RSUD SULTAN IMANUDDIN PANGKALANBUN
Authors: Utomo Kamisun Setyo , Ningtyas Rahaju , Wiludjeng Rahaju 
Published: November 2021

Pengetahuan perawat adalah salah satu faktor penting dalam pelayanan keperawatan yang bermuara pada peningkatan mutu pelayanan. Untuk mewujudkan hal itu maka asuhan keperawatan kepada pasien dilakukan dengan berbagai macam metode keperawatan yang salah satunya adalah metode keperawatan tim primer. Penelitian ini merupakan penelitian analitik kuantitatif dengan desain cross sectional yang bertujuan untuk mengetahui sejauhmana hubungan antara pengetahuan perawat (kepala ruangan, ketua tim, dan perawat pelaksana) dengan penerapan metode keperawatan tim primer di ruang rawat inap RSUD Sultan Imanuddin Pangkalanbun. Total populasi dalam penelitian ini berjumlah 109 orang yang diambil dengan cara total sampling. Hasil analisis bivariat dengan uji Spearman Rank(Rho) pada perawat khususnya kepala ruangan menunjukkan Sig.(2 tailed) (0,428 > 0,05), hasil analisis bivariat khususnya pada ketua tim menunjukkan Sig.(2 tailed) (0,016 < 0,05) dengan kefisien korelasi sebesar 0,649 dan hasil analisis bivariat khususnya pada perawat pelaksana menunjukkan Sig.(2 tailed) (0,008 < 0,05) dengan kefisien korelasi sebesar 0,281. Berdasarkan hasil penelitian disimpulkan bahwa tidak ada hubungan yang signifikan antara pengetahuan perawat khususnya kepala ruangan dengan penerapan metode keperawatan tim primer, ada hubungan yang signifikan dengan tingkat keeratan kuat antara pengetahuan perawat khususnya ketua tim dengan penerapan metode keperawatan tim primer, dan ada hubungan yang signifikan dengan tingkat keeratan cukup antara pengetahuan perawat khususnya perawat pelaksana (PP) dengan penerapan metode keperawatan tim primer.Kata Kunci : Metode tim primer, kepala ruangan, ketua tim, perawat pelaksana
HUBUNGAN TINGKAT PENGETAHUAN IBU TENTANG IMUNISASI DASAR TERHADAP KEPATUHAN PEMBERIAN IMUNISASI DASAR PADA BAYI
Authors: Hasanah Mas Saleha , Lubis Angela Ditauli , Syahleman Rukmini 
Published: November 2021

Pengetahuan tentang imunisasi kepada orang orang tua sangatlah penting bagi kesehatan bayi, hal ini juga harus didukung dengan informasi yang disampaikan kepada masyarakat. Semakin banyak informasi yang didapatkan tentang imunisasi, semakin baik pengetahuannya sehingga akan membentuk kepatuhan pemberian imunisasi semakin baik pula. Penelitian ini bertujuan untuk mengetahui adanya hubungan tingkat pengetahuan ibu tentang imunisasi dasar terhadap kepatuhan pemberian imunisasi dasar pada bayi di wilayah kerja Puskesmas Madurejo Pangkalan Bun. Penelitian ini menggunakan metode penelitian deskriptif kuantitatif dengan desain penelitian cross sectional dengan teknik Acciedental sampling dan jumlah sampel sebanyak 73 responden. Dalam penelitian ini menggunakan Analisa data univariat dan Analisa bivariate dengan menggunakan uji chi square. Hasil uji chi square didapatkan hasil p value = 0,000 (ρ < 0,05) maka H1 diterima dan H0 ditolak, artinya ada hubungan antara tingkat pengetahuan ibu tentang imunisasi dasar terhadap kepatuhan pemberian imunisasi dasar pada bayi di wilayah kerja Puskesmas Madurejo Pangkalan Bun.Kata Kunci: Pengetahuan, kepatuhan, imunisasi dasar
PENANGANAN TERSEDAK “CHOKING”
Authors: Suprapti Dwi 
Published: November 2021

Tersedak merupakan keadaan gawat napas yang masih sering dipandang sebelah mata oleh masyarakat. Menurut data, angka kematian yang disebabkan oleh obstruksi jalan napas khususnya tersedak masih tinggi di kalangan bayi. Riset yang dilakukan oleh Dr.Gary Smith di Nationwide Children’s Hospital menjelaskan bahwa dalam satu dekade terdapat 34 anak dibawah 1 tahun di Amerika dibawa ke IGD karena tersedak makanan dan ASI. Bahaya dari tersedak bila tidak tahu tanda-tanda dari tersedak dan tidak dengan segera dilakukan penanganan dini dapat menyebabkan kesulitan bernapas, kebiruan dan hilang kesadaran. Oleh karena itu, mengetahui tanda- tanda tersedak seperti batuk tanpa suara, kebiruan, ketidakmampuan untuk berbicara atau bernapas. Selain itu, bila ditemukan tanda-tanda penyumbatan ringan dan korban dapat batuk, jangan menghalangi proses batuk dan usaha bernapas spontan dari korban. Pengabdian masyarakat ini dilaksanakan pada hari Rabu, 10 Januari 2018 pukul 10.00 WIB. Sasaran dari kegiatan ini yaitu ibu-ibu di desa Pangkalan Tiga. Metode yang digunakan pada penyuluhan mengenai penanganan tersedak adalah ceramah dan tanya jawab. Agar kedepannya penyuluhan seperti ini dilakukan secara rutin mengenai bantuan hidup dasar sehingga masyarakat dapat melakukan pertolongan segera ketika menghadapi masalah.Kata kunci : Tersedak, Penanganan, Bayi
GAMBARAN KADAR TRIGLISERIDA PADA SUPIR BUS DI PANGKALAN BUN
Authors: Setiyawati Misfa , Hidayah K Nur Aini , Riky Riky 
Published: November 2021

Trigliserida merupakan lemak netral dengan fungsi utama sebagai zat energi. Peningkatan kadar trigliserida dalam darah dapat meningkatkan resiko beberapa penyakit seperti jantung koroner dan stroke. Faktor yang mempengaruhi kadar trigliserida antara lain umur, konsumsi makanan berlemak, aktivitas fisik seperti olahraga, konsumsi rokok dan pola tidur. Tujuan penelitian ini untuk mengetahui gambaran kadar trigliserida pada supir bus di Pangkalan Bun dengan jumlah responden sebanyak 32 orang. Penelitian ini menggunakan metode cross sectional dengan teknik total sampling. Metode pemeriksaan kadar trigliserida yang digunakan adalah metode Enzimatis kolorimetri (GPO-PAP). Data yang diperoleh disajikan secara deskriptif dalam bentuk tabel dan gambar. Hasil yang diperoleh menunjukkan bahwa sebagian besar responden memiliki kadar trigliserida tinggi sebanyak 26 responden (81%) dan hanya sebagian kecil responden sebanyak 6 responden (19%) memiliki kadar trigliserida normal.Kata Kunci : Trigliserida, Supir Bus
Identification of keygenes, miRNAs and miRNA-mRNA regulatory pathways for chemotherapy resistance in ovarian cancer
Authors: Wang Wenwen , Zhang Wenwen , Hu Yuanjing 
Published: November 2021

Background
Chemotherapy resistance, especially platinum resistance, is the main cause of poor prognosis of ovarian cancer. It is of great urgency to find molecular markers and mechanism related to platinum resistance in ovarian cancer.

Methods
One mRNA dataset (GSE28739) and one miRNA dataset (GSE25202) were acquired from Gene Expression Omnibus (GEO) database. The GEO2R tool was used to screen out differentially expressed genes (DEGs) and differentially expressed miRNAs (DE-miRNAs) between platinum-resistant and platinum-sensitive ovarian cancer patients. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for DEGs were performed using the DAVID to present the most visibly enriched pathways. Protein–protein interaction (PPI) of these DEGs was constructed based on the information of the STRING database. Hub genes related to platinum resistance were visualized by Cytoscape software. Then, we chose seven interested hub genes to further validate using qRT-PCR in A2780 ovarian cancer cell lines. And, at last, the TF-miRNA-target genes regulatory network was predicted and constructed using miRNet software.

Results
A total of 63 upregulated DEGs, 124 downregulated DEGs, four upregulated miRNAs and six downregulated miRNAs were identified. From the PPI network, the top 10 hub genes were identified, which were associated with platinum resistance. Our further qRT-PCR showed that seven hub genes (BUB1, KIF2C, NUP43, NDC80, NUF2, CCNB2 and CENPN) were differentially expressed in platinum-resistant ovarian cancer cells. Furthermore, the upstream transcription factors (TF) for upregulated DE-miRNAs were SMAD4, NFKB1, SMAD3, TP53 and HNF4A. Three overlapping downstream target genes (KIF2C, STAT3 and BUB1) were identified by miRNet, which was regulated by hsa-miR-494.

Conclusions
The TF-miRNA–mRNA regulatory pairs, that is TF (SMAD4, NFKB1 and SMAD3)-miR-494-target genes (KIF2C, STAT3 and BUB1), were established. In conclusion, the present study is of great significance to find the key genes of platinum resistance in ovarian cancer. Further study is needed to identify the mechanism of these genes in ovarian cancer.
Biosynthesis of Copper Nanoparticles using Mucuna Pruriens and its Antioxidant and Antidiabetic Activity
Authors: Ali Shifa Jawahar , Geetha R. V. , Rajeshkumar S. 
Published: November 2021

Introduction: The field of Nanotechnology has gained importance since last century. Nanoparticles can be used in medicine due to its increased interaction with microbes and has less side effects than drugs. Antioxidant compounds scavenge free radicals and inhibit the oxidative mechanisms that lead to degenerative diseases. There is a growing number of diabetes patients all over the world. Wide varieties of synthetic drugs are being used for the treatment of Type 2 diabetes mellitus, most of them possess side effects in the long run such as hepatotoxicity, abdominal pain, flatulence and diarrhea. Therefore, there is a need for a search of an alternate antidiabetic agent
Aim: The aim of the study is to synthesize Copper nanoparticles from Mucuna pruriens and to evaluate its antioxidant and antidiabetic activity.
Materials and methods: Plant extract of Mucuna pruriens was prepared and filtered by Whatman No 1 filter paper. Copper sulphate was added to the plant extract and kept in a magnetic stirrer for nanoparticle synthesis. The synthesized nanoparticle was preliminarily analysed using UV visible spectroscopy. Finally the left over solution was taken to calculate antioxidant activity and antidiabetic activity.
Results: Antioxidant activity was calculated by DPPH method and the percentage of inhibition of copper nanoparticles synthesised from Mucuna pruriens was 58.5% for 10µL, 59.6% for 20µL, 67.5% for 30µL, 71.4% for 40µL and 72.3% for 50µL. Antidiabetic activity was calculated by alpha-amylase inhibitory assay and the percentage of inhibition of copper nanoparticles synthesised from Mucuna pruriens was 66% for 10µL, 69% for 20µL, 73% for 30µL, 79% for 40µL and 80% for 50µL.
Conclusion: We can conclude that copper nanoparticles synthesised from Mucuna pruriens are a potent antioxidant and antidiabetic agent. Since it shows a good activity in free radical scavenging, copper nanoparticles can be used in a clinical therapeutic application and also in the management of type 2 diabetes mellitus.
Clinical pearls for the monitoring and treatment of antipsychotic induced metabolic syndrome
Authors: DeJongh Beth M. 
Published: November 2021

Abstract
Antipsychotic medications increase the risk of metabolic syndrome, which then increases the risk of atherosclerotic cardiovascular disease and premature death. Routinely monitoring for signs of metabolic syndrome in patients taking antipsychotics allows for early detection and intervention. Psychiatric pharmacists can improve patient care through metabolic syndrome monitoring and recommendation of appropriate interventions. Monitoring for the metabolic adverse effects of antipsychotics, management of weight gain, and management of lipids and blood pressure are explored through 2 patient cases.
Pharmacotherapy treatment of stimulant use disorder
Authors: Liu Mei T. 
Published: November 2021

Abstract
Stimulant use disorder (SUD) is a public health problem in the United States that is associated with increased morbidity and mortality. Psychosocial interventions, such as cognitive behavioral therapy and contingency management, are the main treatment modality for SUDs and no pharmacotherapy is currently FDA approved for this indication. Although some medications show promising data for the treatment of SUD, the evidence remains inconsistent, and the clinical application is limited due to the heterogenicity of the population and the lack of studies in patients with various comorbidities. Selection of pharmacotherapy treatment for methamphetamine intoxication, persistent methamphetamine-associated psychosis with methamphetamine use disorder, and cocaine use disorder in patients with co-occurring OUD are discussed in 3 patient cases.
Factors influencing performance on the Board Certified Psychiatric Pharmacist Examination: Passing rates and domain-level scores
Authors: Muckle Timothy J. , Dopheide Julie , Gable Kelly , Meng Yu , Johnson Samuel G. , Ellis William 
Published: November 2021

Abstract
The Board Certified Psychiatric Pharmacist (BCPP) specialty certification was launched by the Board of Pharmacy Specialties in 1994. Candidates for the BCPP can qualify for the examination through 3 possible pathways: practice experience (4 years) in the specialty, completion of a PGY-1 residency plus an additional 2 years of practice experience, or completion of a PGY-2 specialty residency in psychiatric pharmacy. Recent fluctuations in the passing rate raised questions as to explanatory factors. This article represents the first published comprehensive study of candidate performance on the BCPP Examination. It describes a retrospective, observational study presenting (a) statistical trends of examination passing rates for biannual cohorts over the past 5 years, as well as (b) score distributions on the 3 performance domains of the certification. Pass-rate trend analyses suggest that variation in the proportion of eligibility pathway cohorts in the respective testing samples explains some of the fluctuation in passing rates. An analysis of variance of domain-level scores, using groups defined by eligibility pathway, yielded significant differences for nearly all group comparisons. Evaluation of the effect sizes suggest that the most disparate performance was observed on the core clinical domain, Patient-Centered Care. The results of this study are consistent with previously published research and will inform the upcoming role delineation study for the Psychiatric Pharmacy Certification.
Microdose induction of buprenorphine-naloxone in a patient using high dose methadone: A case report
Authors: Menard Shannon , Jhawar Archana 
Published: November 2021

Abstract

Background
Buprenorphine is a partial mu-opioid receptor agonist approved for the treatment of opioid dependence. The risk of withdrawal symptoms and wait time required to safely initiate buprenorphine provides challenges to both patients and providers. Microdose induction is proposed as a possible solution to ease the transition to buprenorphine; however, little data has been published to date on patients stabilized on methadone doses greater than 100 mg.

Case Report
A 29-year-old patient stabilized on methadone 105 mg was successfully transitioned to sublingual buprenorphine-naloxone using a 7-day microdose protocol on an inpatient psychiatric service. During the transition, the patient reported only minimal symptoms.

Conclusion
This report adds to the growing literature supporting the use of a microdose induction to initiate buprenorphine-naloxone. Additionally, this approach may be significant for patients stabilized on high doses of methadone who may not be able to tolerate a traditional buprenorphine induction.
Transcranial magnetic stimulation–associated mania with psychosis: A case report
Authors: Knox Erin D. , Bota Robert G. 
Published: November 2021

Abstract
Transcranial magnetic stimulation (TMS) is a noninvasive procedure used in the treatment of depression. We observed TMS-associated mania with psychotic symptoms in a 55-year-old male diagnosed with MDD and generalized anxiety disorder without history of psychosis or mania. Owing to poor pharmacotherapeutic response and worsening symptomatology, TMS was introduced while continuing phenelzine; this was initially successful in demonstrating positive effects on mood. However, the patient began to develop symptoms consistent with mania with psychosis and was hospitalized. Both TMS and phenelzine were discontinued, leading to significant improvement of the symptoms of mania and psychosis. Phenelzine was later reintroduced for maintenance treatment of depression and anxiety, with no recurrence of mania or psychosis. This case report implicates TMS as a possible cause of mania and psychosis symptoms.
Photopolymerized Thin Coating of Polypyrrole/Graphene Nanofiber/Iron Oxide onto Nonpolar Plastic for Flexible Electromagnetic Radiation Shielding, Strain Sensing, and Non‐Contact Heating Applications
Authors: Ganguly Sayan , Kanovsky Naftali , Das Poushali , Gedanken Aharon , Margel Shlomo 
Published: November 2021

AbstractThe current work presents the fabrication of micrometer‐thick single‐side‐coated surface‐engineered polypropylene (PP) film for versatile flexible electronics applications. Herein, the authors report, for the first time, photopolymerized thin coating of graphene nanofibers (GNFs) and iron oxide nanoparticles (IONPs) onto non‐polar plastic via surface chemistry. The fabrication is achieved by adopting three consecutive steps; initially corona treated PP films are treated with silane for thin layer silica coating. Then, the silylated PP films are brushed up by pyrrole/GNFs/IONPs mixture, followed by UV exposure. The coated films show surface conductivity in the range of ≈20 S cm−1 at room temperature. Moreover, ≈15 microns of the coated film is tested against electromagnetic waves in the X‐band region (8.2–12.4 GHz) and its shielding behavior (≈24 dB) is confirmed. To demonstrate its wide range of versatility, the coated films are tested against angular strain and oscillatory magnetic fields. The results confirm angle dependent strain sensitivity and induction heating obeying Néel relaxation. To the best of the authors’ knowledge, this is the first synergistic coating archived for mitigating radiation pollution, strain sensing, and non‐contact heating.
High‐Efficiency Top‐Emitting Green Perovskite Light Emitting Diode with Quasi Lambertian Emission
Authors: Cai Lei , Zhou Jungui , Bai Guilin , Zang Jiaqing , El‐Shaer Abdelhamid , Song Tao , Fung Man‐Keung , Sun Baoquan 
Published: November 2021

AbstractMetal halide perovskite light‐emitting diodes (PeLEDs) are regarded as alternative candidates for next‐generation display technologies due to their high efficiency, superior color purity, tunable bandgap. However, the research on transparent and top‐emitting PeLED with Lambertian emission profile significantly lags behind due to optical microcavity effect, which has become one of the main obstacles for potential practical display applications. Here, strategies are developed to suppress the microcavity effect by enhancing the transmission of the semitransparent electrode and extending the optical cavity length. Besides, a nanopatterned structure is incorporated to suppress the surface plasma and waveguide mode effect. Based on the above combination strategies, a transparent PeLED yields a record total external quantum efficiency (EQE) of 16.1% with Lambertian emission by depositing high refractive index molybdenum oxide on the semitransparent cathode. Besides, a high EQE of 13.6% of a top‐emitting device with quasi‐Lambertian emission is achieved by stretching the optical distance between two reflective layers and enhancing the transmission of the semitransparent electrode. The nanopatterned structure enables suppressed waveguide mode and surface plasmon polariton dilapidation of top‐emitting PeLEDs. This work paves a path to design transparent and top‐emitting PeLEDs for potential applications in both traditional and novel transparent displays.
Enhanced Hot Carrier Up‐Conversion in Graphene By Quantum Dot Coating
Authors: Ma He , Shang Nianze , Liang Jing , Liu Chang , Wang Fangfang , Zhao Mengze , Zhang Zhibin , Zhang Zhihong , Ma Chaojie , Liu Can , Wu Muhong , Shen Huaibin , Hong Hao , Liu Kaihui 
Published: November 2021

AbstractGraphene with unique linear band structure and enhanced electron–electron interaction exhibits peculiar hot‐carrier generation. The thermalized hot carriers in graphene have potential to achieve high energy which is well above energy of the incident photons. Together with its outstanding optical and electrical properties, the exotic thermalization of hot carriers makes graphene a promising material for applications in optical up‐conversion devices and ultrafast photonics. However, the excitation efficiency of hot carriers is limited by its weak absorption and atomically thin light–matter interaction length. Here, the efficient hot‐carrier amplification is demonstrated in graphene by adjacent quantum dots (QD). With pump–probe experiments, this hot carrier amplification is found to stem from the charge collection of the two‐photon excited hot carriers in QD. Taking advantages of strong absorption of QD, the hot‐carrier excitation efficiency of graphene can be efficiently improved under near‐infrared sub‐bandgap excitation of QD. The transferred hot carriers are with energy higher than those originally excited in graphene, leading to raised hot‐carrier temperature and enhanced hot‐carrier up‐conversion. This research demonstrates QD's immense potential to realize high efficiency hot‐carrier injection in graphene‐based devices, which will promote their ability for hot‐carrier‐driven devices, optical up‐conversion devices and high‐frequency optoelectronics.
Citrate Promotes Excessive Lipid Biosynthesis and Senescence in Tumor Cells for Tumor Therapy
Authors: Zhao Yangjing , Liu Xia , Si Fusheng , Huang Lan , Gao Aiqin , Lin Wenli , Hoft Daniel F. , Shao Qixiang , Peng Guangyong 
Published: November 2021

AbstractMetabolic disorder is one of the hallmarks of cancers, and reprogramming of metabolism is becoming a novel strategy for cancer treatment. Citrate is a key metabolite and critical metabolic regulator linking glycolysis and lipid metabolism in cellular energy homeostasis. Here it is reported that citrate treatment (both sodium citrate and citric acid) significantly suppresses tumor cell proliferation and growth in various tumor types. Mechanistically, citrate promotes excessive lipid biosynthesis and induces disruption of lipid metabolism in tumor cells, resulting in tumor cell senescence and growth inhibition. Furthermore, ATM‐associated DNA damage response cooperates with MAPK and mTOR signaling pathways to control citrate‐induced tumor cell growth arrest and senescence. In vivo studies further demonstrate that citrate administration dramatically inhibits tumor growth and progression in a colon cancer xenograft model. Importantly, citrate administration combined with the conventional chemotherapy drugs exhibits synergistic antitumor effects in vivo in the colon cancer models. These results clearly indicate that citrate can reprogram lipid metabolism and cell fate in cancer cells, and targeting citrate can be a promising therapeutic strategy for tumor treatment.