bluuebunny/crossref_metadata_2025_split huggingface dataset:
General dimensions of human brain morphometry inferred from genome-wide association data
Authors: Fürtjes Anna E. , Arathimos Ryan , Coleman Jonathan R. I. , Cole James H. , Cox Simon R. , Deary Ian J. , de la Fuente Javier , Madole James W. , Tucker-Drob Elliot M. , Ritchie Stuart J. 
Published: October 2021

AbstractBackgroundUnderstanding the neurodegenerative mechanisms underlying cognitive declines in the general population may facilitate early detection of adverse health outcomes in late life. This study investigates biological pathways shared between brain morphometry, ageing, and cognitive ability.MethodsWe develop Genomic Principal Components Analysis (genomic PCA) to model general dimensions of variance in brain morphometry within brain networks at the level of their underlying genetic architecture. With genomic PCA we extract genetic principal components (PCs) that index global dimensions of genetic variance across phenotypes (unlike ancestral PCs that index genetic similarity between participants). Genomic PCA is applied to genome-wide association data for 83 brain regions which we calculated in 36,778 participants of the UK Biobank cohort. Using linkage disequilibrium score regression, we estimate genetic overlap between brain networks and indices of cognitive ability and brain ageing.ResultsA genomic principal component (PC) representing brain-wide dimensions of shared genetic architecture accounted for 40% of the genetic variance across 83 individual brain regions. Genomic PCs corresponding to canonical brain networks accounted for 47-65% of the genetic variance in the corresponding brain regions. These genomic PCs were negatively associated with brain age (rg = −0.34). Loadings of individual brain regions on the whole-brain genomic PC corresponded to sensitivity of a corresponding region to age (r = - 0.27). We identified positive genetic associations between genomic PCs of brain morphometry and general cognitive ability (rg= 0.17-0.21).ConclusionThese results demonstrate substantial shared genetic etiology between connectome-wide dimensions of brain morphometry, ageing, and cognitive ability, which will help guide investigations into risk factors and potential interventions of ageing-related cognitive decline.
A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer
Authors: Haderk Franziska , Fernández-Méndez Celia , Čech Lauren , Yu Johnny , Meraz Ismail M. , Olivas Victor , Rabago Dora Barbosa , Lucas Kerr D. , Gomez Carlos , Allegakoen David V. , Guan Juan , Shah Khyati N. , Herrington Kari A. , Gbenedio Oghenekevwe M. , Nanjo Shigeki , Majidi Mourad , Tamaki Whitney , Rotow Julia K. , McCoach Caroline E. , Riess Jonathan W. , Silvio Gutkind J. , Tang Tracy T. , Post Leonard , Huang Bo , Santisteban Pilar , Goodarzi Hani , Bandyopadhyay Sourav , Kuo Calvin J. , Roose Jeroen P. , Wu Wei , Blakely Collin M. , Roth Jack A. , Bivona Trever G. 
Published: October 2021

AbstractTargeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alterations in EGFR, ALK and KRAS. The success of targeted therapy is limited by drug-tolerant tumor cells which withstand and adapt to treatment and comprise the residual disease state that is typical during treatment with clinical targeted therapies. Here, we integrate studies in patient-derived and immunocompetent lung cancer models and clinical specimens obtained from patients on targeted therapy to uncover a focal adhesion kinase (FAK)-YAP signaling axis that promotes residual disease during oncogenic EGFR-, ALK-, and KRAS-targeted therapies. FAK-YAP signaling inhibition combined with the primary targeted therapy suppressed residual drug-tolerant cells and enhanced tumor responses. This study unveils a FAK-YAP signaling module that promotes residual disease in lung cancer and mechanism-based therapeutic strategies to improve tumor response.
Identification and assessment of the antibacterial activity of Vigna mungo and Rhizobacteria
Authors: Kwatra Bharat 
Published: October 2021

1.ABSTRACTSZnO nanoparticles have received a lot of interest in recent years due to their unusual features. Antimicrobial properties of ZnO NPs However, the qualities of nanoparticles are determined by their size and form, making them suitable for a variety of applications. The current work looks at the synthesis, characterization, and antibacterial activity of ZnO NPs produced by Vigna Mungo and Rhizobacteria. Rhizobacteria isolated from V. mungo root nodule were morphologically, biochemically, and molecularly examined and identified as Rhizobium sp. strain and Bacillus flexus strain. The GC-MS analysis of methanol leaf extract of V. mungo was performed to detect and identify bioactive chemicals, and this indicated phytol as an antibacterial agent, while Squalene and Alpha – tocopherol had antioxidant and anti-tumour properties. Agar well diffusion experiment was used to determine the antibacterial properties of ZnO nanoparticles and Vigna Mungo leaf extract. This approach is widely documented, and standard zones of inhibition for sensitive and resistant values have been defined. The results demonstrated that both methanol extract and zinc oxide nanoparticles have strong antibacterial efficacy against the majority of the pathogens examined.
Spatial coding in the hippocampus of flying owls
Authors: Agarwal Arpit , Sarel Ayelet , Derdikman Dori , Ulanovsky Nachum , Gutfreund Yoram 
Published: October 2021

SummaryThe elucidation of spatial coding in the hippocampus requires exploring diverse animal species. While robust place-cells are found in the mammalian hippocampus, much less is known about spatial coding in the hippocampus of birds – and nothing is known about avian spatial representation during flight. Here we used a wireless-electrophysiology system to record single neurons in the hippocampus and related pallial structures from freely flying barn owls (Tyto alba) – a central-place nocturnal predator species with excellent navigational abilities. The owl’s 3D position was monitored while it flew back and forth between two perches. We found place cells – neurons that robustly represented the owl’s location during flight, and its flight-direction – as well as neurons that coded the owl’s perching position between flights. Spatial coding was invariant to changes in lighting conditions and to the position of a salient object in the room. Place cells were found in the anterior hippocampus and in the adjacent posterior hyperpallium apicale, and to a much lesser extent in the visual Wulst (visual-cortex homologue). The finding of place-cells in flying owls suggests commonalities in spatial coding across a variety of species – including rodents, bats and owls.
Quantification of breeding sites parameters in shaping bacterial communities in Aedes aegypti (Diptera: Culicidae)
Authors: Normandeau-Guimond Josiann , Hery Lyza , Guidez Amandine , Durand Audrey-Anne , Delannay Christelle , Issaly Jean , Raffestin Stéphanie , Nigro Joseph , Vega-Rúa Anubis , Constant Philippe , Guertin Claude , Dusfour Isabelle 
Published: October 2021

AbstractStudies have demonstrated the importance of breeding site, few had disentangled the role of microbiome, physico-chemical and biological factors of water as well as landuse on larval microbial communities and their recruitment in mosquito. A quantitative exploration of the interplay of multiple factors on mosquito microbiome was performed using a dataset obtained through a field survey undertaken in French Guiana. Two complementary hypotheses were tested (i) the most dissimilar larval microbiome structures in breeding sites displayed the most contrasting water properties and land-use, (ii) a higher specificity level of environmental parameters have an incidence on larval microbiome. Variance partitioning approach validated the two hypothesis by providing evidence that water bacterial community is a most significant driver shaping the structure of the bacteriome in mosquito than other environmental parameters from the breeding sites. However, land-use does not play such important role to explain variance. Our results consolidate and complement the knowledge shaping mosquito microbiota but also highlighted the large unknown in understanding the ecology of the recruitment into host.
Bid-ask spread, corporate board and stock liquidity in emergent markets
Authors: Daadaa Wissem 
Published: October 2021

PurposeThis study analyzes the relationship between governance and stock liquidity. It uses different variables of corporate board characteristics and test three proxies of a bid-ask spread. It also provides comprehensive and robust evidence for the association between the corporate board and stock liquidity in the pure order-driven Tunisian market.Design/methodology/approachThis study is based on a sample covering all financial firms in Tunisia (banks, insurances and leasing companies) from 2008 to 2019. It employs a panel data approach.FindingsThe author finds a negative relationship between board sizes, financial institutional members in corporate board and bid-ask spread (absolute, relative and effective spread). The author suggests that better-managed firms have greatly improved their stock liquidity and lower trading cost. The empirical results reveal that better corporate governance firms improve stock liquidity since it is associated with higher information disclosure.Practical implicationsThis research encourages Tunisian firms to develop their governance mechanisms and restructure their board organization to improve stock liquidity. It can support the regulators to simultaneously design appropriate governance recommendations, disclosure policies and trading regulations.Originality/valueThe author presents empirical evidence of the role of corporate board on the bid-ask spread in an emerging market. The research is the first to analyze the corporate board characteristics using seven variables representatives of the board of directors and without using the governance index.
Management geographical proximity and stock price crash risk
Authors: Jin Xin , Liang Shangkun , Yu Junli 
Published: October 2021

PurposeThis study provides empirical support for the cultural economics model between executive team and firm performance and offers important implications for policy selection and appointment of managers in China.Design/methodology/approachFrom the perspective of relationship embeddedness, the authors explore the impact of management geographical proximity (GP) on stock price crash risk in China. Using archival data from China's unique dataset about birthplace culture, the authors find that management GP experiences a large increase in corporate stock price crash risk for the period 2009–2018.FindingsThe impact of management GP on stock price crash risk is more pronounced when the company is located in areas with weaker formal legal environment and stronger Confucian culture. Furthermore, the impact has a significant links with firm characteristics such as information transparency, over-investment and tax aggressiveness.Originality/valueFirst, the research extends the literature on the empirical determinants of stock price crash risk. These studies focus on formal institution, not on informal institution, such as relational culture. Second, the research provides evidence for economic consequences on relational governance from executive birthplace culture to explore the economic consequences of geographical relational governance but takes stock price crash risk to present executives' behavior strategies and market reaction via exploring asymmetrical variation of market stock price. Finally, the paper provides reference to corporate governance arrangement and executive appointment.
Bank stability, credit information sharing and a shift toward households' lending: international evidence
Authors: Le Tu D.Q. , Nguyen Dat T. 
Published: October 2021

PurposeThe study aims to investigate the relationship between a shift in lending activities toward households, credit information sharing and bank stability.Design/methodology/approachA system generalized method of moments (GMMs) as proposed by Arellano and Bover (1995) is employed to examine the relationship using a sample of 80 countries from 2005 to 2014.FindingsThe findings demonstrate that, in general, a shift in lending strategy toward the household sector may increase bank instability while credit information sharing has a positive impact on bank stability. When credit information sharing is promoted widely, this shift may become beneficial for the banking system. The results are robust when using different measures of credit information sharing, including the depth of index and the coverage of credit information sharing mechanisms.Practical implicationsThe results demonstrate that a shift in lending activities toward households should be considered a key variable in conducting macro-prudential policies. When a shift toward household credit relative to firm credit is evolved, the findings suggest that the authorities around the world should enact laws that magnify the scope and coverage of credit information shared and thus promoting the effectiveness of information sharing.Originality/valueThe current study is the first attempt that examines the impacts of a shift in lending activities toward households and credit information sharing on bank stability.
Collaborating in a health-care process: partner, not customer
Authors: Karlsson Margareta 
Published: October 2021

Purpose
The internal customer concept is used with different definitions and purposes in research and in practice – an ambiguity with implications for both scholars and practitioners. The purpose of this study is, therefore, to explore the representation of the internal customer concept in quality management literature and reflect on how the user may affect collaboration in health-care processes, in particular between a service function and health-care staff.

Design/methodology/approach
A review of the internal customer concept in the literature, followed by a conceptual discussion based on previous studies and theories of organizational discourse.

Findings
Three predominant types of relationships related to the internal customer concept were found. The study shows that the ambiguity in the use of the concept may have consequences for the interpretation and application of research results. Potential undesirable consequences with regard to collaboration in processes are discussed.

Originality/value
This study contributes to a new understanding of the internal customer concept in research and practice. As collaboration within and between organizations is increasingly required in many parts of health care, careful considerations become necessary regarding concepts used for relationships to avoid sub-optimization and “us-versus-them” thinking and to strengthen trust-based relationships.
Impact of corporate life cycle on misclassification practices: evidence from IFRS adoption in India
Authors: Bansal Manish 
Published: October 2021

PurposeThe study aims to examine the impact of the firm life cycle on the misclassification practices of Indian firms. The study also examines the impact of International Financial Reporting Standards (IFRS) on the misclassification practices of Indian firms.Design/methodology/approachThe study uses Dickinson (2011) cash flow patterns to classify firm-years under life cycle stages. Two forms of misclassification, namely revenue misclassification and expense misclassification have been examined in this study.FindingsBased on a sample of 19,268 Bombay Stock Exchange (BSE) firm-years spanning over ten years from March 2010 to March 2019, results show that firms operating at high (low) life cycle stage are more likely to be engaged in revenue (expense) misclassification, implying that firms substitute between the classification shifting tools depending upon ease and needs of each tool. Further, our results demonstrate that the magnitude of expense shifting has been significantly increased among test firms (firms reporting under IFRS) relative to benchmark firms (firms reporting under domestic GAAP) in the post-IFRS adoption period, implying that adoption of IFRS negatively affects the accounting quality of Indian firms.Research limitations/implicationsThe study considers only two main forms of misclassification, namely revenue and expense misclassification. However, future research may explore the cash flow misclassification.Practical implicationsThe findings suggest that standard-setting authorities make more mandatory disclosure requirements under IFRS to curb the corporate misfeasance of classification shifting.Originality/valueFirst, the study is among the earlier attempts to examine the impact of the firm life cycle on misclassification practices. Second, the study explores the unique Indian institutional settings concerning the phased-manner implementation of IFRS and examines its impact on the classification shifting practices of firms.
Assessing the possibility of financing social health insurance from zakat, case of Sudan: ARDL bounds approach
Authors: Mohammed Idris Fawzia , Seraj Mehdi , Ozdeser Huseyin 
Published: October 2021

Purpose
The purpose of this study is to find funding sources for social health insurance in Sudan to cover vulnerable families.

Design/methodology/approach
The concept of this paper is to look into the causality relationship between insured and directly paid poor people and their incomes through using the autoregressive distributed lag model (ARDL) and using a survey raw data carried out in 2010 in Sudan.

Findings
The findings show that insured vulnerable people and income-generating activities have a significant positive relationship. The results, on the other hand, show a marginally negative effect on income for those who have directly paid poor people.

Originality/value
Previous research on the position of zakat has focused primarily on its role in poverty alleviation and has given little consideration to its role in social security. This study is characterized by improving the possibility of changing the mechanism of distributing zakat funds in favor of health financing to maximize the benefit.
High‐performance computing strategies for seismic‐imaging software on the cluster and cloud‐computing environments
Authors: Okita Nicholas T. , Camargo Alexandre W. , Ribeiro José , Coimbra Tiago A. , Benedicto Caian , Faccipieri Jorge H. 
Published: October 2021

ABSTRACTModern subsurface imaging techniques allow obtaining high‐quality images but with high computational costs. Nonetheless, depending on the amount of data, their execution is limited by memory in the current generation's hardware. However, with the advancement of new hardware and cloud‐based solutions, these problems are mitigated but still with the risk of work loss and instability. To mitigate the execution problems in memory‐limited and fail‐prone environments, we propose two high‐performance computing techniques. The first is based on independent checkpointing alongside a fault‐tolerant framework to store an execution state and recover from that state in case of failures. Besides, for memory‐limited graphics processing units, we present a technique to reduce the amount of memory requirement that we call the hybrid strategy. The experiments showed that the independent checkpointing alongside the fault‐tolerant framework is able to mitigate the performance penalty of node failures, with the independent checkpointing technique being more relevant when multiple nodes are terminated. Furthermore, the hybrid strategy technique has shown the possibility of execution of larger models that could make the graphics processing unit run out of memory otherwise. Finally, our implementation is scalable, allowing a significant improvement in performance when adding new nodes. In conclusion, our techniques can be used to deliver fast, high‐fidelity subsurface imaging in unstable and memory‐limited environments, such as the cloud.
Ecology of Listeria monocytogenes and Listeria species in India: the occurrence, resistance to biocides, genomic landscape and biocontrol
Authors: Barbuddhe Sukhadeo Baliram , Rawool Deepak Bhiwa , Doijad Swapnil Prakash , Vergis Jess , Malik Satyaveer Singh , Chakraborty Trinad 
Published: October 2021

SummaryListeria monocytogenes, the causative agent of listeriosis, has been implicated in increasing foodborne outbreaks worldwide. The disease is manifested in various forms ranging from severe sepsis in immune‐compromised individuals, febrile gastroenteritis, still birth, abortions and meningoencephalitis. In India, data from studies on the detection and molecular epidemiological analysis of L. monocytogenes are only recently emerging. The presence of Listeria in different ecological niches has been recorded from India, including foods, soil, vegetables, mangrove swamps, seafood, freshwater fishes, clinical cases, and also insects. The organism has also been isolated from women with spontaneous abortions, miscarriage or recurrent obstetric history, aborted foetuses, animal clinical cases and wildlife samples. A novel species of Listeria has also been characterized. Listeria monocytogenes strains isolated from clinical, environmental, and foods showed biofilm‐forming abilities. Listeria monocytogenes serotype 4b isolates of ST328, a predominant and unique ST observed in India, was repeatedly isolated from different sources, times, and geographical locations. Here, we reviewed the occurrence of Listeria in different sources in India, its resistance to biocides, and provide epidemiological analysis on its genomic landscape.
Felt deficits in time with children: Individual and contextual factors across 27 European countries
Authors: Berghammer Caroline , Milkie Melissa A. 
Published: October 2021

AbstractA sizeable portion of parents say they lack time with children—an important social problem given that time strains link to parental well‐being. Extending perspectives on the demands and rewards of parenting beyond the individual level, we provide a contextual‐level window onto mothers' and fathers' time strains. Based on data from the European Quality of Life Survey 2016/17 (n = 5,898), we analyze whether parents feel they spend enough time caring for their children using multilevel models. We first observe that country context matters in that perceptions of time only moderately or weakly relate to hours with children across countries, especially for fathers, suggesting varying social expectations across Europe. Second, in multivariate analyses examining micro‐ and macro‐level factors, we show that at the individual level, feeling too little time with children is more frequent among fathers and those who work more hours, even when controlling for estimated weekly hours spent caring for children. At the country level, parents' time strain is higher in countries where employees have less time and place flexibility, typically in Central and Eastern as well as Southern Europe. Gender norms matter as well. Extending contextual perspectives, we argue that how gender‐work‐family regimes color felt time strain is a promising future research direction.
The UK's wealth distribution and characteristics of high‐wealth households
Authors: Advani Arun , Bangham George , Leslie Jack 
Published: October 2021

AbstractWe show that wealth inequality in the UK is high and has increased slightly over the past decade as financial asset prices have increased in the wake of the financial crisis. But data deficiencies are a major barrier in understanding the true distribution, composition and size of household wealth. The most comprehensive survey of household wealth in the UK does a good job of capturing the vast majority of the wealth distribution, but nearly £800 billion of wealth held by the very wealthiest UK households is missing. We also find tentative evidence that survey measures of high‐wealth families undervalue their assets – our central estimate of the true value of wealth held by households in the UK is 5 per cent higher than the survey data suggest.