bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular beam epitaxial growth of hexagonal boron nitride on Ni foils
Authors: Hadid Jawad , Colambo Ivy , Boyaval Christophe , Nuns Nicolas , Dudin Pavel , Avila Jose , Wallart Xavier , Vignaud Dominique 
Published: July 2021

Abstract
Hexagonal boron nitride (h-BN) was synthesized by molecular beam epitaxy on polycrystalline Ni foils using borazine (B3N3H6) as precursor. Our photoemission analysis shows that several components of boron and nitrogen are detected, suggesting the complex nature of the bonds noticeably at the h-BN/Ni interface. The BN thickness was estimated by photoemission and the BN distribution by time-of-flight secondary ion mass spectroscopy. Due to the catalytic effect of the Ni substrate, this thickness is self-limited in the range 1–2 layers regardless of the borazine dose. A spatially resolved photoemission study was carried out before and after transfer of the h-BN on a Si substrate. It shows that a strong electronic coupling exists at the interface between h-BN and polycrystalline Ni, not only for (111) grains, which disappears after transfer on Si. In addition, we highlight the importance of detecting π plasmons in the photoemission spectra to confirm the hexagonal nature of BN.
Dynamics near the central singularity in spherical collapse
Authors: Guo Jun-Qi 
Published: July 2021

Abstract
We study the dynamics near the central singularity in spherically symmetric collapse of a massless scalar field toward Schwarzschild black hole formation. The equations of motion take different simplified forms in the early and late stages of the singularity curve. We report some fine structures of the analytic solutions and universal features for the metric functions and matter near the singularity.
Local structure and dynamics of tungsten oxide-based glasses: insights from concurrent neutron diffraction and Compton scattering
Authors: Krzystyniak Matthew , Drużbicki Kacper , Tolnai Istvan , Fabian Margit 
Published: July 2021

Abstract
In this work, following our previous work on molybdate glasses, we employ a combination of neutron diffraction and neutron Compton scattering, augmented by ab initio harmonic lattice dynamics and Reverse Monte Carlo modelling to characterise the force-constant disorder in the tungsten oxide-based glasses. Specifically, we discuss the correlations between the average interatomic force constant magnitudes inferred from neutron Compton scattering and the glass formation ability, measured in terms of the value of the glass transition temperature, as well as the average bond-lengths and interatomic distances obtained from diffraction data analysis. Moreover, we provide a comparative analysis of the widths of force-constant distributions of individual atomic species in glasses and their precursor metal oxides based on the distributions of the widths of nuclear momentum distributions. Furthermore, we assess the degree of softening of atom-projected vibrational densities of states induced by the force-constant disorder in the glasses.
Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn’s disease
Authors: El-Hussuna A , Karer M L M , Uldall Nielsen N N , Mujukian A , Fleshner P R , Iesalnieks I , Horesh N , Kopylov U , Jacoby H , Al-Qaisi H M , Colombo F , Sampietro G M , Marino M V , Ellebæk M , Steenholdt C , Sørensen N , Celentano V , Ladwa N , Warusavitarne J , Pellino G , Zeb A , Di Candido F , Hurtado-Pardo L , Frasson M , Kunovsky L , Yalcinkaya A , Tatar O C , Alonso S , Pera M , Granero A G , Rodríguez C A , Minaya A , Spinelli A , Qvist N 
Published: July 2021

Abstract

Background
In patients with active Crohn’s disease (CD), treatment of intra-abdominal abscess usually comprises antibiotics and radiologically guided percutaneous drainage (PD) preceding surgery. The aim of this study was to investigate the risk of postoperative complications and identify the optimal time interval for surgical intervention after PD.

Methods
A multicentre, international, retrospective cohort study was carried out. Details of patients with diagnosis of CD who underwent ultrasonography- or CT-guided PD were retrieved from hospital records using international classification of disease (ICD-10) diagnosis code for CD combined with procedure code for PD. Clinical variables were retrieved and the following outcomes were measured: 30-day postoperative overall complications, intra-abdominal septic complications, unplanned intraoperative adverse events, surgical-site infections, sepsis and pathological postoperative ileus, in addition to abscess recurrence. Patients were categorized into three groups according to the length of the interval from PD to surgery (1–14 days, 15–30 days and more than 30 days) for comparison of outcomes.

Results
The cohort comprised 335 CD patients with PD followed by surgery. Median age was 33 (i.q.r. 24–44) years, 152 (45.4 per cent) were females, and median disease duration was 9 (i.q.r. 3.6–15) years. Overall, the 30-day postoperative complications rate was 32.2 per cent and the mortality rate was 1.5 per cent. After adjustment for co-variables, older age (odds ratio 1.03 (95 per cent c.i. 1.01 to 1.06), P &lt; 0.012), residual abscess after PD (odds ratio 0.374 (95 per cent c.i. 0.19 to 0.74), P &lt; 0.014), smoking (odds ratio 1.89 (95 per cent c.i. 1.01 to 3.53), P = 0.049) and low serum albumin concentration (odds ratio 0.921 (95 per cent c.i. 0.89 to 0.96), P &lt; 0.001) were associated with higher rates of postoperative complications. A short waiting interval, less than 2 weeks after PD, was associated with a high incidence of abscess recurrence (odds ratio 0.59 (95 per cent c.i. 0.36 to 0.96), P = 0.042).

Conclusion
Smoking, low serum albumin concentration and older age were significantly associated with postoperative complications. An interval of at least 2 weeks after successful PD correlated with reduced risk of abscess recurrence.
K.Vita: a feasibility study of a blend of medium chain triglycerides to manage drug-resistant epilepsy
Authors: Schoeler Natasha E , Orford Michael , Vivekananda Umesh , Simpson Zoe , Van de Bor Baheerathi , Smith Hannah , Balestrini Simona , Rutherford Tricia , Brennan Erika , McKenna James , Lambert Bridget , Barker Tom , Jackson Richard , Williams Robin S B , Sisodiya Sanjay M , Eaton Simon , Heales Simon J R , Cross J Helen , Walker Matthew C ,   K.Vita Study Group, Rajakulendran Sanjeev , Vezyroglou Aikaterini , Pujar Suresh , Kalser Judith , Eltze Christin , Varadkar Sophia , Robinson Robert , Rahman Shamima 
Published: July 2021

Abstract
This prospective open-label feasibility study aimed to evaluate acceptability, tolerability and compliance with dietary intervention with K.Vita, a medical food containing a unique ratio of decanoic acid to octanoic acid, in individuals with drug-resistant epilepsy. Adults and children aged 3–18 years with drug-resistant epilepsy took K.Vita daily whilst limiting high-refined sugar food and beverages. K.Vita was introduced incrementally with the aim of achieving ≤35% energy requirements for children or 240 ml for adults. Primary outcome measures were assessed by study completion, participant diary, acceptability questionnaire and K.Vita intake. Reduction in seizures or paroxysmal events was a secondary outcome. 23/35 (66%) children and 18/26 (69%) adults completed the study; completion rates were higher when K.Vita was introduced more gradually. Gastrointestinal disturbances were the primary reason for discontinuation, but symptoms were similar to those reported from ketogenic diets and incidence decreased over time. At least three-quarters of participants/caregivers reported favourably on sensory attributes of K.Vita, such as taste, texture and appearance, and ease of use. Adults achieved a median intake of 240 ml K.Vita, and children 120 ml (19% daily energy). Three children and one adult had ß-hydroxybutyrate &gt;1 mmol/l. There was 50% (95% CI 39–61%) reduction in mean frequency of seizures/events. Reduction in seizures or paroxysmal events correlated significantly with blood concentrations of medium chain fatty acids (C10 and C8) but not ß-hydroxybutyrate. K.Vita was well accepted and tolerated. Side effects were mild and resolved with dietetic support. Individuals who completed the study complied with K.Vita and additional dietary modifications. Dietary intervention had a beneficial effect on frequency of seizures or paroxysmal events, despite absent or very low levels of ketosis. We suggest that K.Vita may be valuable to those with drug-resistant epilepsy, particularly those who cannot tolerate or do not have access to ketogenic diets, and may allow for more liberal dietary intake compared to ketogenic diets, with mechanisms of action perhaps unrelated to ketosis. Further studies of effectiveness of K.Vita are warranted.
Incorporation of quantitative MRI in a model to predict temporal lobe epilepsy surgery outcome
Authors: Morita-Sherman Marcia , Li Manshi , Joseph Boney , Yasuda Clarissa , Vegh Deborah , De Campos Brunno Machado , Alvim Marina K M , Louis Shreya , Bingaman William , Najm Imad , Jones Stephen , Wang Xiaofeng , Blümcke Ingmar , Brinkmann Benjamin H , Worrell Gregory , Cendes Fernando , Jehi Lara 
Published: July 2021

Abstract
Quantitative volumetric brain MRI measurement is important in research applications, but translating it into patient care is challenging. We explore the incorporation of clinical automated quantitative MRI measurements in statistical models predicting outcomes of surgery for temporal lobe epilepsy. Four hundred and thirty-five patients with drug-resistant epilepsy who underwent temporal lobe surgery at Cleveland Clinic, Mayo Clinic and University of Campinas were studied. We obtained volumetric measurements from the pre-operative T1-weighted MRI using NeuroQuant, a Food and Drug Administration approved software package. We created sets of statistical models to predict the probability of complete seizure-freedom or an Engel score of I at the last follow-up. The cohort was randomly split into training and testing sets, with a ratio of 7:3. Model discrimination was assessed using the concordance statistic (C-statistic). We compared four sets of models and selected the one with the highest concordance index. Volumetric differences in pre-surgical MRI located predominantly in the frontocentral and temporal regions were associated with poorer outcomes. The addition of volumetric measurements to the model with clinical variables alone increased the model’s C-statistic from 0.58 to 0.70 (right-sided surgery) and from 0.61 to 0.66 (left-sided surgery) for complete seizure freedom and from 0.62 to 0.67 (right-sided surgery) and from 0.68 to 0.73 (left-sided surgery) for an Engel I outcome score. 57% of patients with extra-temporal abnormalities were seizure-free at last follow-up, compared to 68% of those with no such abnormalities (P-value = 0.02). Adding quantitative MRI data increases the performance of a model developed to predict post-operative seizure outcomes. The distribution of the regions of interest included in the final model supports the notion that focal epilepsies are network disorders and that subtle cortical volume loss outside the surgical site influences seizure outcome.
Flush+Reload Attacks on SEED
Authors: Seddigh Milad , Soleimany Hadi 
Published: July 2021

Abstract
Flush+Reload is a powerful access-driven cache attack in which the attacker leverages a security weakness in the X86 processor architecture to extract the private data of the victim. This attack can be mounted in a cross-core setting, where the memory deduplication is enabled and several users are sharing the same physical machine. In this paper, for the first time, we demonstrate that SEED implementation of OpenSSL 1.1.0 running inside the victim VM is vulnerable against the Flush+Reload attacks and the attacker can recover the keys of this encryption. SEED is a standard encryption algorithm that was developed by the Korea Information Security Agency (KISA) and has been used for confidential services in the Republic of Korea. Our work demonstrates that the attacker can retrieve the secret keys of SEED in 3 min in the native setup and 4 min in the cross-VM setup by performing the Flush+Reload technique. Our experimental results show that common implementation of this standard cipher is vulnerable to Flush+Reload attack in both native and cross-VM settings. To the best of our knowledge, this paper presents the first cache-based attack on a SEED block cipher.
Insomnia symptoms and incident heart failure: a population-based cohort study
Authors: Mahmood Asos , Ray Meredith , Dobalian Aram , Ward Kenneth D , Ahn SangNam 
Published: July 2021

Abstract

Aims
Heart failure (HF) is an ongoing epidemic and a serious clinical and public health issue. Currently, little is known about prospective associations between insomnia symptoms and HF incidence. We investigated the longitudinal associations between time-varying insomnia symptoms (difficulty initiating sleep, difficulty maintaining sleep, early-morning awakening, non-restorative sleep) and incident HF.

Methods and results
Data were obtained from the Health and Retirement Study in the US for a population-representative sample of 12,761 middle-aged and older adults (age ≥ 50 years; mean [SD] age, 66.7 [9.4] years; 57.7% females) who were free from HF at baseline in 2002. Respondents were followed for 16 years for incident HF. We employed marginal structural discrete-time survival analyses to adjust for potential time-varying biological, psycho-cognitive, and behavioral factors and to account for bias due to differential loss to follow-up. At baseline, 38.4% of the respondents reported experiencing at least one insomnia symptom. During the 16-year follow-up, 1,730 respondents developed incident HF. Respondents experiencing one (hazard ratio [HR]=1.22; 95% CI: 1.08–1.38), two (HR=1.45; 95% CI: 1.21–1.72), three (HR=1.66; 95% CI: 1.37–2.02), or four (HR=1.80; 95% CI: 1.25–2.59) insomnia symptoms had a higher hazard of incident HF than asymptomatic respondents. Respondents that had trouble initiating sleep (HR=1.17; 95%CI: 1.01–1.36), maintaining sleep (HR=1.14; 95% CI: 1.01–1.28), early-morning awakening (HR=1.20; 95% CI: 1.02–1.43), or non-restorative sleep (HR=1.25; 95% CI: 1.06–1.46) had a higher hazard of incident HF than asymptomatic respondents.

Conclusion
Insomnia symptoms, both cumulatively and individually, are associated with incident HF. Public health awareness and screening for insomnia symptoms in at-risk populations should be encouraged to reduce HF incidence.
Functional Dissection of Yeast Hir1p, a WD Repeat–Containing Transcriptional Corepressor
Authors: DeSilva Heshani , Lee Kenneth , Osley Mary Ann 
Published: July 2021

AbstractThe HIR1 gene product is required to repress transcription of three of the four histone gene loci in Saccharomyces cerevisiae, and like its counterpart, the HIR2 protein, it functions as a transcriptional corepressor. Although Hir1p and Hir2p are physically associated in yeast, Hir1p is able to function independently of Hir2p when it is artificially recruited to the histone HTA1 promoter. A deletion analysis of HIR1 has revealed two separate repression domains: one in its N terminus, where seven copies of the β-transducin or WD40 motif reside, and the second in the remaining C-terminal amino acids. Overexpression of the WD repeats in a hir1Δ strain complemented its Hir− phenotype, while overexpression of the C terminus in a wild-type strain caused both Hir− and Spt− phenotypes. The Hir1p C terminus physically interacted in vivo with Hir2p, and both Hir1p repression domains interacted with full-length Hir1p. It was additionally found that the Hir1p WD repeats functionally interacted with the SPT4, SPT5, and SPT6 gene products, suggesting that these repeats may direct Hir1p to different protein complexes.
EMS-Induced Polygenic Mutation Rates for Nine Quantitative Characters in Drosophila melanogaster
Authors: Keightley Peter D , Ohnishi Ohmi 
Published: July 2021

Abstract
Polygenic mutations were induced by treating Drosophila melanogaster adult males with 2.5 mm EMS. The treated second chromosomes, along with untreated controls, were then made homozygous, and five life history, two behavioral, and two morphological traits were measured. EMS mutagenesis led to reduced performance for life history traits. Changes in means and increments in genetic variance were relatively much higher for life history than for morphological traits, implying large differences in mutational target size. Maximum likelihood was used to estimate mutation rates and parameters of distributions of mutation effects, but parameters were strongly confounded with one another. Several traits showed evidence of leptokurtic distributions of effects and mean effects smaller than a few percent of trait means. Distributions of effects for all traits were strongly asymmetrical, and most mutations were deleterious. Correlations between life history mutation effects were positive. Mutation parameters for one generation of spontaneous mutation were predicted by scaling parameter estimates from the EMS experiment, extrapolated to the whole genome. Predicted mutational coefficients of variation were in good agreement with published estimates. Predicted changes in means were up to 0.14% or 0.6% for life history traits, depending on the model of scaling assumed.
Evidence for Genetic Hitchhiking Effect Associated With Insecticide Resistance in Aedes aegypti
Authors: Yan Guiyun , Chadee Dave D , Severson David W 
Published: July 2021

Abstract
Information on genetic variation within and between populations is critical for understanding the evolutionary history of mosquito populations and disease epidemiology. Previous studies with Drosophila suggest that genetic variation of selectively neutral loci in a large fraction of genome may be constrained by fixation of advantageous mutations associated with hitchhiking effect. This study examined restriction fragment length polymorphisms of four natural Aedes aegypti mosquito populations from Trinidad and Tobago, at 16 loci. These populations have been subjected to organophosphate (OP) insecticide treatments for more than two decades, while dichlor-diphenyltrichlor (DDT) was the insecticide of choice prior to this period. We predicted that genes closely linked to the OP target loci would exhibit reduced genetic variation as a result of the hitchhiking effect associated with intensive OP insecticide selection. We also predicted that genetic variability of the genes conferring resistance to DDT and loci near the target site would be similar to other unlinked loci. As predicted, reduced genetic variation was found for loci in the general chromosomal region of a putative OP target site, and these loci generally exhibited larger FST values than other random loci. In contrast, the gene conferring resistance to DDT and its linked loci show polymorphisms and genetic differentiation similar to other random loci. The reduced genetic variability and apparent gene deletion in some regions of chromosome 1 likely reflect the hitchhiking effect associated with OP insecticide selection.
Genetic Analysis of Punt, a Type II Dpp Receptor That Functions Throughout the Drosophila melanogaster Life Cycle
Authors: Simin Karl , Bates Emily A , Horner Michael A , Letsou Anthea 
Published: July 2021

Abstract
TGF-β- (transforming growth factor-β-) mediated signal transduction affects growth and patterning in a variety of organisms. Here we report a genetic characterization of the Drosophila punt gene that encodes a type II serine/threonine kinase TGF-β/Dpp (Decapentaplegic) receptor. Although the punt gene was originally identified based on its requirement for embryonic dorsal closure, we have documented multiple periods of punt activity throughout the Drosophila life cycle. We demonstrate that potentially related embryonic punt phenotypes, defects in dorsoventral patterning and dorsal closure, correspond to distinct maternal and zygotic requirements for punt. In addition, we document postembryonic requirements for punt activity. The tight correspondence between both embryonic and postembryonic loss-of-function punt and dpp phenotypes implicates a role for Punt in mediating virtually all Dpp signaling events in Drosophila. Finally, our comparison of punt homoallelic and heteroallelic phenotypes provides direct evidence for interallelic complementation. Taken together, these results suggest that the Punt protein functions as a dimer or higher order multimer throughout the Drosophila life cycle.
Meta-Analysis of Linkage Data under Worst-Case Conditions: A Demonstration Using the Human OB Region
Authors: Allison David B , Heo Moonseong 
Published: July 2021

Abstract
To date, few methods have been developed explicitly for meta-analysis of linkage analyses. Moreover, the methods that have been developed or suggested generally depend on certain ideal situations and have not been widely applied. In this article, we apply standard statistical theory and meta-analytic techniques in novel ways to five published papers discussing the evidence of linkage of body mass index (BMI) to the region of the human genome containing the OB gene. These methods are “inference based,” meaning that they allow one to make statements about the statistical significance of the entire body of evidence. As currently developed, they do not allow specific statements to be made about the amount of variance explained by any putative locus or allow precise confidence intervals to be placed around the putative location of a linked locus. By applying these techniques to the literature on linkage in the human OB gene region, we are able to show that the evidence for linkage somewhere in the region is extremely strong (P = 1.5 × 10−5).
Genetic Conflicts, Multiple Paternity and the Evolution of Genomic Imprinting
Authors: Spencer Hamish G , Feldman Marcus W , Clark Andrew G 
Published: July 2021

Abstract
We present nine diallelic models of genetic conflict in which one allele is imprintable and the other is not to examine how genomic imprinting may have evolved. Imprinting is presumed to be either maternal (i.e., the maternally derived gene is inactivated) or paternal. Females are assumed to be either completely monogamous or always bigamous, so that we may see any effect of multiple paternity. In contrast to previous verbal and quantitative genetic models, we find that genetic conflicts need not lead to paternal imprinting of growth inhibitors and maternal imprinting of growth enhancers. Indeed, in some of our models—those with strict monogamy—the dynamics of maternal and paternal imprinting are identical. Multiple paternity is not necessary for the evolution of imprinting, and in our models of maternal imprinting, multiple paternity has no effect at all. Nevertheless, multiple paternity favors the evolution of paternal imprinting of growth inhibitors and hinders that of growth enhancers. Hence, any degree of multiple paternity means that growth inhibitors are more likely to be paternally imprinted, and growth enhancers maternally so. In all of our models, stable polymorphism of imprinting status is possible and mean fitness can decrease over time. Neither of these behaviors have been predicted by previous models.