bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring ethnic fermented drink ‘Pakhoi’ for its therapeutic properties: An in-silico perspective
Authors: Tomar Shikha , Kotnala Shalini , Riya  , Chauhan Kuldeep , Sharma Anmol , Pant Manu , Singh Pallavi , Sharma Sumit , Pant Kumud 
Published: December 2024

The tribes of the Tons Valley in Uttarakhand, India, prepare Pakhoi, a traditional drink, as the subject of the current study. This drink is known to have therapeutic properties and has potential applications in anti-cancer research. The present study investigates the antiproliferative activity of key compounds found in this drink. Numerous computational tools have assessed the physicochemical properties, pharmacokinetics, drug likeness, and medicinal chemistry of these compounds. SwissADME and Molsoft were utilized to determine properties such as drug likeness scores, especially for Tomentin, which showed the highest score of 1.09. To evaluate anticancer potential, PASS Online software was employed to obtain bioactivity scores; the program reports activity as probable activity (Pa) with values ranging from 0.000 to 1.000 and has a 95% accuracy rate. Pa values greater than 0.7 suggest greater pharmacological action, whereas values less than 0.7 indicate less activity. A variety of drugs regulate ion channel modulators, crucial therapeutic targets that facilitate the passage of charged particles across cell membranes. The next server predicted Haplopine, molecule 4, to be the most bioactive ion channel modulator, with a score of 0.35. Molinspiration: Kinase inhibitors are drugs that selectively inhibit or alter disease-related signaling. Atherospermidine, one of the components in the drink, displayed a bioactivity score of 0.32 as a kinase inhibitor. CLC-Pred was employed to determine the cytotoxicity of major compounds found in the drink for specific cancer cell lines, which shows the value of Pa 0.907 and Pi 0.004. Furthermore, we used PaccMann, a compound that indicates efficacy against cancer cell lines, to determine the IC50 value. It predicted that Narciclasine and Tomentin would be efficient in reducing the proliferation of certain cell lines. Molecular docking was conducted to gain insights into the molecular interaction between the compounds and their specific targets, and the ligand shows the best binding affinity with the protein target CDK4 with -9.7 binding affinity. Swiss Target Prediction helped identify the targets associated with the compounds. The study provided significant insights into the potential of the tribal drink as an anticancer therapeutic agent.
Intrathoracic gastric perforation in the context of giant hiatal hernia TYPE III
Authors: García Redondo M , Ruiz Pardo J , Martin Cano J , Sánchez Fuentes PA , Vidaña Márquez E , Reina Duarte Á 
Published: December 2024

Resumen

La hernia de hiato es una patología frecuente con sintomatología leve en la mayoría de los casos. Las complicaciones derivadas de ella son infrecuentes, requiriendo cirugía urgente el 1-2% de los casos. Se expone el caso clínico de una hernia de hiato tipo III gigante incarcerada, que en ese contexto sufre una perforación gástrica intratorácica. Por este motivo requiere intervención quirúrgica urgente, realizando una gastrectomía total con anastomosis esófagoyeyunal. Se añaden imágenes de la tomografía y del hallazgo intraoperatorio. La incarceración de la hernia de hiato suele presentar una exacerbación de la sintomatología. De este modo, puede progresar desde la inflamación hasta la isquemia transmural gástrica con necrosis asociada. Aunque la técnica quirúrgica en la cirugía urgente de la hernia de hiato no está claramente definida, en algunos casos con isquemia y necrosis asociada, la gastrectomía parcial o segmentaria podría ser suficiente. Sin embargo, en casos de afectación isquémica y necrosis extensas, como sucedió en el caso presentado, puede ser necesaria la gastrectomía total.
Gastrointestinal obstruction due to Rapunzel’s Syndrome: Laparoscopic Approach. A Case Report.
Authors: Blanco Vargas J , Hernandez Sandoval EA , Avilez Arias JM , Esquer García MF 
Published: December 2024

Resumen

Introduction: En este caso se reporta a una mujer de 36 años con antecedentes de tricofagia, quien presentó síntomas de oclusión intestinal. Los bezoares, masas intraluminales no digeribles, y en particular los tricobezoares, por su rareza y desafíos diagnósticos y terapéuticos, se vuelven objeto de interés médico.

Presentación del caso: La paciente experimentó dos semanas de intolerancia oral, vómitos, distensión abdominal y ausencia de peristalsis. Los estudios tomográficos revelaron la presencia de tricobezoares en el estómago y el yeyuno. La laparoscopia confirmó la tricofagia y permitió la exitosa extracción de ambos bezoares, destacando la necesidad de intervención quirúrgica.

Conclusión: La discusión se centra en el Síndrome Rapunzel, un tricobezoar infrecuente vinculado a la tricofagia. Se subraya la importancia de la detección temprana y la comprensión de complicaciones como úlceras gástricas y obstrucción intestinal. La elección de la extracción laparoscópica como opción terapéutica destaca la complejidad del tricobezoar. En conclusión, se enfatiza la necesidad crítica de una atención médica oportuna frente a esta condición.
Acute abdomen due to Streptococcus pyogenes in a male with a history of abdominal trauma and oropharyngeal infection.
Authors: Pérez Reyes M , Sánchez Díaz AM , González Sánchez AJ , Qian Zhang SÁ , Santoyo Santoyo J 
Published: December 2024

Resumen

Introducción: La peritonitis primaria por Streptococcus pyogenes es una entidad poco frecuente.

Caso clínico: Presentamos un varón de 36 años con antecedentes de traumatismo abdominal que acude a urgencias por dolor abdominal generalizado. Ante exploración física, TAC abdominal y analítica de sangre patológicas e inestabilidad hemodinámica se decidió intervención quirúrgica urgente, objetivando una peritonitis purulenta generalizada sin identificar la causa. Se tomó muestra para cultivo aislando Streptococo pyogenes. Rehistoriando al paciente refería antecedentes de infección de origen orofaríngea.

Discusión: Se han descrito pocos casos en la literatura, en la mayoría mujeres y se sospecha se suelen ser por diseminación ascendente por el tracto genital, pero lo particular de nuestro paciente es que era varón y por otro lado había tenido antecedentes de clínica orofaríngea una semana previa y otro dato confusor que fue lo que nos condujo a intervención quirúrgica era el antecedente del traumatismo abdominal.
Robotic approach to locally advanced splenic flexure tumor
Authors: Lobato Bancalero L , Arrebolan L , Mokachir Y , Martos N , Álvarez MS , González J , Ortega A , Roldan J , Fernández F 
Published: December 2024

Resumen

El abordaje de los tumores del ángulo esplénico es técnicamente exigente. Además clásicamente se ha considerado que los tumores T4 no son abordables por vía endoscópica. Presentamos el caso de una mujer de 52 años con un tumor localmente avanzado a nivel del ángulo esplénico del colon. Consideramos que la cirugía robótica en este caso nos permite realizar una mejor disección consiguiendo realizar una cirugía R0. La magnificación de la imagen nos permite la exéresis completa del tumor y de la infiltración local de la pared abdominal, así como la conservación del bazo. Realizamos la ligadura de la vena mesentérica inferior completando la linfenectomía y realizando una hemicolectomía izquierda con anastomosis intracorpórea. La minimización del daño tisular permiten una pronta recuperación.
Investigating the Star Formation Characteristics of Radio Active Galactic Nuclei
Authors: Zhang Bojun , Zou Fan , Brandt W. N. , Zhu Shifu , Cristello Nathan , Ni Qingling , Xue Yongquan , Yu Zhibo 
Published: December 2024

Abstract
The coevolution of supermassive black holes and their host galaxies represents a fundamental question in astrophysics. One approach to investigating this question involves comparing the star formation rates (SFRs) of active galactic nuclei (AGNs) with those of typical star-forming galaxies. At relatively low redshifts (z ≲ 1), radio AGNs manifest diminished SFRs, indicating suppressed star formation, but their behavior at higher redshifts is unclear. To examine this, we leveraged galaxy and radio-AGN data from the well-characterized W-CDF-S, ELAIS-S1, and XMM-LSS fields. We established two mass-complete reference star-forming galaxy samples and two radio-AGN samples, consisting of 1763 and 6766 radio AGNs, the former being higher in purity and the latter more complete. We subsequently computed star-forming fractions (f
SF; the fraction of star-forming galaxies to all galaxies) for galaxies and radio-AGN host galaxies and conducted a robust comparison between them up to z ≈ 3. We found that the tendency for radio AGNs to reside in massive galaxies primarily accounts for their low f
SF, which also shows a strong negative dependence upon M
⋆ and a strong positive evolution with z. To investigate further the star formation characteristics of those star-forming radio AGNs, we constructed the star-forming main sequence (MS) and investigated the behavior of the position of AGNs relative to the MS at z ≈ 0–3. Our results reveal that radio AGNs display lower SFRs than star-forming galaxies in the low-z and high-M
⋆ regime and, conversely, exhibit comparable or higher SFRs than MS star-forming galaxies at higher redshifts or lower M
⋆.
Probing the Equation of State of Neutron Stars with Captured Primordial Black Holes
Authors: Gao 郜 Qing 青 , Dai 戴 Ning 宁 , Gong 龚 Yungui 云贵 , Zhang 张 Chao 超 , Zhang 张 Chunyu 春雨 , Zhao 赵 Yang 阳 
Published: December 2024

Abstract
Gravitational waves (GWs) from primordial black holes (PBHs) inspiraling within neutron stars (NSs)—should they exist—are detectable by ground-based detectors and offer a unique insight into the internal structure of NSs. To provide accurate templates for GW searches, we solve Einstein’s equations within NSs and calculate the orbital motion of the captured PBH by considering dynamical friction, accretion, and gravitational radiation. Equipped with precise GW waveforms for PBHs inspiraling inside NSs, we find that the Einstein Telescope can differentiate between various equations of state for NSs. As PBHs inspiral deeper into NSs, the GW frequency rises near the surface, then decreases to a constant value deeper within NSs. The distinctive characteristics of GW frequency serve as the smoking gun for GW signals emitted by PBHs inspiraling inside NSs and can be used to probe the nuclear matter in the crust and core of NSs.
Laboratory Studies on Absolute n-resolved Charge-exchange Cross Sections and Modeling X-Ray Emissions for Ne8+ Colliding with H2 and He
Authors: Ma P. F. , Yin H. , Ren B. , Meng T. , Wang J. , Wu Y. , Tan X. , Zhang Y. , Qi Y. , Yao K. , Xiao J. , Zou Y. , Tu B. , Wei B. 
Published: December 2024

Abstract
Charge exchange is a predominant process in inelastic collisions in astronomical plasmas, influencing the charge state balance and leading to X-ray emissions when solar wind ions interact with neutral gas in astrophysical environments. Accurate analysis of these dynamic properties to diagnose the solar wind composition and velocities, as well as the spatial distribution of the heliospheric neutral gas, can be hindered by the limited availability of relevant electron capture studies in the corresponding energy range. The absolute total and

n

-resolved state-selective cross sections of single electron capture have been measured in the collisional energy range from 2.8 to 40 keV u−1, covering velocities corresponding to fast solar wind and coronal mass ejections. In comparison with existing atomic data, we observe good agreement with other results at overlapping energies. Based on the absolute

n

-state electron capture cross sections, the absolute cross sections of photon emissions following charge exchange between Ne8+ and H2, as well as He gas, were determined for the potential applications in high-resolution X-ray spectra studies of solar wind charge exchange. This work serves as a benchmark for validating the theoretical calculations of charge exchange cross sections and astronomical plasma models, providing valuable insights into the investigation of soft X-ray emissions in solar wind plasma environments.
Expanding the Ultracompacts: Gravitational-wave-driven Mass Transfer in the Shortest-period Binaries with Accretion Disks
Authors: Chakraborty Joheen , Burdge Kevin B. , Rappaport Saul A. , Munday James , Chen Hai-Liang , Rodríguez-Gil Pablo , Dhillon V. S. , Hughes Scott A. , Nelemans Gijs , Kara Erin , Bellm Eric C. , Brown Alex J. , Castro Segura Noel , Chen Tracy X. , Chickles Emma , Dyer Martin J. , Dekany Richard , Drake Andrew J. , Garbutt James , Graham Matthew J. , Green Matthew J. , Jarvis Dan , Kennedy Mark R. , Kerry Paul , Kulkarni S. R. , Littlefair Stuart P. , Mahabal Ashish A. , Masci Frank J. , McCormac James , Parsons Steven G. , Pelisoli Ingrid , Pike Eleanor , Prince Thomas A. , Riddle Reed , van Roestel Jan , Sahman Dave , Wold Avery , Sunny Wong Tin Long 
Published: December 2024

Abstract
We report the discovery of three ultracompact binary white dwarf systems hosting accretion disks, with orbital periods of 7.95, 8.68, and 13.15 minutes. This significantly augments the population of mass-transferring binaries at the shortest periods, and provides the first evidence that accretors in ultracompacts can be dense enough to host accretion disks even below 10 minutes (where previously only direct-impact accretors were known). In the two shortest-period systems, we measured changes in the orbital periods driven by the combined effect of gravitational-wave emission and mass transfer. We find

P

̇

is negative in one case, and positive in the other. This is only the second system measured with a positive

P

̇

, and it is the most compact binary known that has survived a period minimum. Using these systems as examples, we show how the measurement of

P

̇

is a powerful tool in constraining the physical properties of binaries, e.g., the mass and mass–radius relation of the donor stars. We find that the chirp masses of ultracompact binaries at these periods seem to cluster around

M

c

∼
0.3

M

⊙

, perhaps suggesting a common origin for these systems or a selection bias in electromagnetic discoveries. Our new systems are among the highest-amplitude known gravitational-wave sources in the millihertz regime, providing an exquisite opportunity for multimessenger study with future space-based observatories such as LISA and TianQin. We discuss how such systems provide fascinating laboratories to study the unique regime where the accretion process is mediated by gravitational waves.
Can the Central Compact Object in HESS J1731–347 Be Indeed the Lightest Neutron Star Observed?
Authors: Zhang 张 S. R. 书瑞 , Rueda Hernandez J. A. , Negreiros R. 
Published: December 2024

Abstract
The exceptionally low mass of

0.7

7

−
0.17

+
0.2

M

⊙

for the central compact object (CCO) XMMU J173203.3–344518 (XMMU J1732) in the supernova remnant (SNR) HESS J1731–347 challenges standard neutron star (NS) formation models. The nearby post–asymptotic giant branch star IRAS 17287–3443 (≈​​​​​​0.6M
⊙), also within the SNR, enriches the scenario. To address this puzzle, we advance the possibility that the gravitational collapse of a rotating presupernova (SN) iron core (≈1.2M
⊙) could result in a low-mass NS. We show that angular momentum conservation during the collapse of an iron core rotating at ≈45% of the Keplerian limit results in a mass loss of ≈0.3M
⊙, producing a stable newborn NS of ≈0.9M
⊙. Considering the possible spin-down, this indicates that the NS is now slowly rotating, thus fulfilling the observed mass–radius relation. Additionally, the NS's surface temperature (≈2 × 106 K) aligns with canonical thermal evolution for its ≈4.5 kyr age. We propose the pre-SN star, likely an ultrastripped core of ≈4.2M
⊙, formed a tidally locked binary with IRAS 17287–3443, with a 1.43 day orbital period. The SN led to a ≈3M
⊙ mass loss, imparting a kick velocity ≲670 km s−1, which disrupted the binary. This scenario explains the observed 0.3 pc offset between XMMU J1732 and IRAS 17287–3443 and supports the possibility of CCOs forming in binaries, with rotation playing a key role in core collapse, and the CCO XMMU J1732 being the lightest NS ever observed.
BRICS yesterday, today and tomorrow: unpacking the peculiarities going forward from South African perspective
Authors: Isheloke Byelongo Elisée 
Published: December 2024

South Africa (SA) joined BRICS in 2010. The study explores the impact of its partnership with the BRICS group on mineral beneficiation in South Africa (SA) from its inception. The BRICS association, that had originally sought to deal with economic issues the founding members faced, became a full-fledged “umbrella organization”, which factors into its engagements a variety of issues including those of policy and polity, economy and culture and certainly the relations between the member countries.
The study culminates in designing a Mineral Beneficiation Model proposed to South Africa with the aim to enhance the cooperation between Brazil, Russia, India, China and South Africa in mining; beyond that, it addresses issues pertaining to the aftermath of the association’s metamorphosis into BRICS Plus.
In South Africa, up to 54 different minerals are extracted from its mines every day, of which a huge quantity is exported abroad to the detriment of local beneficiation entrepreneurs. The BRICS Business Council has previously identified three priorities: infrastructure development, mining beneficiation and mineral beneficiation. At that time, the mining sector contributed around 8% to the South African GDP, but there was not no agreement upon mineral beneficiation model. The involvement of BRICS partners in the extractive industry, however, required interventions to promote mining synergies. The authors sought to develop a model based on the data collected mainly through interviews and questionnaires. The study targeted 79 mining and related companies. A 30% response rate was achieved for the quantitative part of the study and 80% of participants, company representatives among them, were interviewed. The study has shown that South Africa needs to embrace beneficiation and achieve synergy effects when working with the other BRICS Plus members.
Un mausolée pour André Mazon : origines et vocations de la « bibliothèque-musée » Léon Tolstoï
Authors: Pousson Guilhem , Pueyo Barbara 
Published: December 2024

Cet article examine la genèse de la bibliothèque-musée Tolstoï fondée par André Mazon (1881-1967) en 1952 à partir des fonds légués par Tat’âna Suhotina-Tolstaâ et Charles Salomon, traducteur français de Tolstoï. Le don de Tat’âna Suhotina-Tolstaâ, le legs de Charles Salomon sont le résultat des sociabilités d’André Mazon d’une part avec la famille Tolstoj, d’autre part avec les intellectuels proches de Desjardins et les philologues qui structurent la réception de son œuvre en France. La bibliothèque-musée, en ce sens, peut être comprise comme le réceptacle d’une mémoire partagée entre ces deux groupes, et fournit des éléments pour penser une histoire de réseaux d’intellectuels transnationaux liés à l’écrivain. Le « foyer d’études » établi par Mazon a vocation à devenir un espace de collégialité entre les chercheurs français et certains philologues exerçant en URSS, malgré la guerre froide alors à son paroxysme. À l’exception des individualités de Butčik et de Tat’âna Suhotina-Tolstaâ (liées à la bibliothèque à travers Mazon), la communauté émigrée russe semble jouer un rôle relativement marginal dans le développement de la collection. En tout état de cause, le destin de la bibliothèque rappelle le rôle crucial des liens personnels dans les échanges culturels entre l’Est et l’Ouest. Ces relations se substituent largement aux contacts institutionnels – qui déclinent, mais ne disparaissent pas –, permettant ainsi de répondre (très partiellement) à une situation de recherche empêchée.
Catalogue des manuscrits liturgiques du Mont Saint-Michel
Authors: Chevalier Louis , Lecouteux Stéphane 
Published: December 2024

Haut lieu de la spiritualité médiévale, le Mont Saint-Michel est aujourd’hui l’un des sites touristiques les plus connus dans le monde entier, et l’un des plus visités de France. Si le cadre de vie des moines du Moyen Âge est perceptible grâce aux bâtiments conservés in situ, en revanche le patrimoine spirituel et musical de la communauté ne nous est accessible que par des livres aujourd’hui dispersés. L’objectif de ce catalogue est de décrire la documentation liturgique montoise, en proposant une notice pour chacun des vingt-deux manuscrits et fragments qui nous sont parvenus. Il s’attache aussi à présenter et illustrer l’évolution des décors et des notations musicales en usage dans l’abbaye, entre l’an mil et la fin du Moyen Âge. Une introduction, qui se veut didactique, permettra au lecteur de replacer cette documentation dans le contexte de l’histoire de l’abbaye et de sa communauté, en le resituant plus largement dans l’histoire de l’Occident chrétien. L’étude et la comparaison des sources et des usages liturgiques révèlent l’intérêt de ce type de documentation historique, souvent négligé.
“Thinking Upon Paper”: Lady Sarah Lyttelton’s Journey to the Baltic
Authors: Zonca Marta 
Published: December 2024

Lady Sarah Lyttelton, best‑known for her late roles as Lady of the Bedchamber to Queen Victoria (1837‑1842) and Governess of the Royal Children (1843‑1850), is notable for having travelled to Sweden and Russia on her honeymoon in 1813, a period still beset by the conflicts and tensions caused by the Napoleonic Wars. Although her presence in the historical context of the Baltic has been largely neglected, her personal correspondence and travel diary, both of which were partially published by her niece Maud Mary Lyttelton Wyndham in 1912 as Correspondence of Sarah Spencer, Lady Lyttelton, 1787‑1870, offer a unique and interesting perspective on Anglo‑Swedish and Anglo‑Russian relations during this tumultuous period. By examining Lady Lyttelton’s journey and unpublished correspondence, I aim to reconstruct her narrative within the Baltic region and to grant her mostly overlooked written account recognition in the field of travel writing. Indeed, Lady Lyttelton’s remarks provide an insight into the political and social situation of the time. The very route of her honeymoon is telling. She and her husband travelled directly to Gothenburg, bypassing Denmark, Napoleon’s ally, recently defeated by Britain at the Battle of Lyngør (1812). The couple then crossed the Baltic Sea to Finland, recently annexed to Russia, now a safe destination after the latter’s changes of allegiance. After a wintry sojourn in St Petersburg, they made their way back by land, through the recently besieged and burned Riga (1812) and the weakened Prussian provinces.