bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sondas fluorescentes, una revisión general: propiedades, diseño y aplicaciones
Authors: Briones-Vázquez Cristian Alain , Álvarez-Hernández Alejandro 
Published: July 2021

Las sondas fluorescentes son compuestos químicos que presentan el fenómeno óptico de fluorescencia y son utilizados en la detección cualitativa y/o cuantitativa de una gran variedad de analitos. En consecuencia, se han convertido en una herramienta eficiente para la obtención de información dinámica sobre la localización y cuantificación de moléculas de interés. En este artículo, se describen conceptos generales alrededor de las sondas fluorescentes: historia, propiedades químicas y físicas, equipos de detección, características estructurales para el diseño y síntesis, mecanismos de acción frente a los analitos y algunas aplicaciones en el área de polímeros (elucidación de mecanismos, determinación de cinética, observación de cambios de morfología, etc.), en la obtención de imagen de tejidos y/o células en tiempo real en el área médico-biológica y en la detección de especies químicas potencialmente tóxicos, relacionados con la contaminación del medio ambiente
Las redes sociales en la educación
Authors: Jaimes-Barrera Sandra Alejandra , Ramírez-Aguilar Paola Viridiana , Quijano-Luna Brenda Margarita , De León-Vazquez Irma Isabel , Flores-Jiménez Ivette , Tapia-Castillo Delia Iliana 
Published: July 2021

El auge y la propagación de las redes sociales ha alcanzado niveles impensados. Gracias a los aportes de la Web 2.0 las redes sociales están ganando terreno frente a otras alternativas de comunicación. Una red social es una estructura social compuesta de personas, las cuales están conectadas por uno o varios tipos de relaciones, tales como amistad, parentesco, intereses comunes, intercambios económicos, o que comparten creencias o conocimiento.
Como lo menciona el autor “Levis, Diego” Las redes sociales tienen un enorme atractivo en el aspecto personal y de relación por parte del que las usa. Por este motivo, cuanto mayor sea el número de los participantes más atracción genera en los alumnos.
Retomando lo escrito por el autor “Juan José del Haro” Es indudable que la información se mueve a través de la tecnología y hay que saber sacarle provecho; en donde comenta que la educación ha cambiado de manera rápida en la actualidad, los maestros ya no son la única fuente de información a la que los alumnos pueden acudir ya que gracias a este acceso universal, encontramos alumnos que son “expertos” en determinadas áreas del conocimiento que son de su interés y son capaces de aprender de forma autónoma.
El autor “Irene Garrigós” nos dice que las redes sociales y el uso de la tecnología en la docencia va en auge ya que estas son muy útiles creando una comunicación más estrecha entre los alumnos y el profesor.
Artero (2011) dice que en el manejo de una red social en el aula puede suponer un acercamiento entre el docente y el alumno. Los profesores dejan de ser comunicadores o transmisores de conocimiento para ser tutores que guían a los alumnos a través del proceso educativo intentando potenciar la participación de los mismos.
Gli Studi Iberici: passato, presente, futuro
Authors: Pérez Isasi Santiago 
Published: July 2021

This article intents to offer a panoramic view of the field of Iberian Studies, a fairly young academic field devoted to the study of Iberian literatures and cultures, which has gained some level of recognition and visibility in recent years. I will present its multiple genealogy, its different origins and theoretical foundations in diverse geographical and academic spaces; its current state, with a quantitative and qualitative analysis of its publications and of its level of institutionalization, and some proposals for its future development, based on the most recent debates and criticisms about this discipline. I will try to show that, without any intention of becoming homogenic or hegemonic, Iberian Studies have promoted new ways of studying Iberian cultures superseding linguistic, political or academic barriers.
Results of Treatment of Patients with Ureterolithiasis by Extracorporal Shock Wave Lithotripsy on Siemens Modularis Uro
Authors: Vozianov Oleksandr 
Published: July 2021

Extracorporeal shock wave lithotripsy (ESWL) has been used in the treatment of urolithiasis since 1980s. The method has proven to be effective and minimally invasive, but in last years the effectiveness of the method has decreased significantly from 90 % to 60 %. Studying of the causes of this phenomenon and methods of improving treatment outcomes are important problems of modern minimally invasive urology.
The objective: to evaluate the effectiveness of the application of ESWL on Siemens Modularis Uro in the treatment of patients with ureterolithiasis.
Materials and methods. ESWL was performed in 662 patients with ureteral stones ranging in size from 5 mm to 19 mm on Siemens Modularis Uro.
Results. In 95.01 % of cases, the urinary tract was free of stones by the method of ESWL, the removal of stones in 1 session occurred in 376 (56.8 %) patients, with repeated – in 253 (43.2 %) patients. In 33 (4.99 %) patients the result of ESWL was unsatisfactory, fragmentation or elimination of stone fragments did not occur and for these patients ureteroscopy (ureterolithotripsy) was performed as second stage of treatment. During endoscopic intervention in 78.8 % of patients the fragmentation was satisfactory (fragments were smaller than 4 mm), but the elimination of fragments did not occur due to changes of the wall of the ureter in the area of its primary location. The overall rate of stone fragmentation after ESWL sessions in the patients in the trial was 98.94 %. Conducting ESWL with the proposed parameters did not affect the effectiveness of the method (p>0.1), but allowed to significantly increase the life of medical equipment. No complications directly related to lithotripsy were detected.
Conclusion. The obtained results make possible to consider ESWL as a priority method of treatment for patients with ureteral stones up to 15 mm, taking into account the risk factors of inefficiency.
Influence of Radioactive Background on an Idiopathic Form of Infertility Incidence in Men from Different Regions of Ukraine
Authors: Gorpynchenko Ihor , Gurzhenko Yurii , Spyrydonenko Volodymyr , Lytvynets Yevhen 
Published: July 2021

There are 143 men (group I) with idiopathic infertility in the form of asthenozoospermia of the II degree living in the territories of the Kiev region (Poles’ky, Chernobylsky, Ivan’kovsky, Borodyansky, Vyshgorodsky districts) were investigated in the Department of Sexual Pathology and Andrology of the SI «Institute of Urology of the National Academy of Medical Sciences of Ukraine» and exposed to ionizing radiation due to the Chernobyl accident in 1986. All individuals in the I group were born from parents who were in the accident at the Chernobyl nuclear power station in the area of radioactive contamination and permanently resided in areas with a high level of radioactivity. The control group was made up of persons born and living in the Ivano-Frankivsk region with a similar condition (group II, n=57). The mean age of the studied group I was 28,3±2,4 years, and persons of the II group were 30,1±2,8 years. Diagnosis of II was performed ambulatory in accordance with WHO and Ministry of Health of Ukraine standards. The study was to study and compare spermogram parameters in patients from both groups.
It has been established that the reproductive problems of men with idiopathic infertility living in radiation-polluted areas of the Kiev region of Ukraine consist in a significant violation of the quality indicators of ejaculate (mobility by the pool A+B is less than 1,6 times, p<0,05) correlating with modifications of physicochemicals (the average time of liquefaction is 1,4 times greater, p<0,05) and biochemical (decrease of levels of fructose by 2,2 times, citrate – by 1,6 times, p<0,01–0,05) data characterizing the effect of ionizing radiation, as one one of the leading factors of male genital function violation. The study found that the level of general indicators of spermogramm is significantly worse in the regions of Ukraine who were exposed to radioactive contamination due to the Chernobyl accident, in contrast to the indicators of persons from conditionally pure regions.
Efficacy of an Herbal Preparation Based on Lovage, Rosemary, and Centaury on Patients After Extracorporal Shockwave Lithotripsy
Authors: Vitkovskyy Volodymyr 
Published: July 2021

Study objective: to study the effect of a herbal preparation containing a standardised BNO 1040 extract* (based on lovage root, rosemary leaves and aerial parts of centaury) on the extracorporeal shockwave lithotripsy (ESWL) results in patients with urolithiasis (UL).
Methodology. 150 patients with UL (aged 18–65 years) treated with ESWL method were divided into 2 equal groups. The main group (n = 75) received standard recommendations and herbal preparation (12 months). The control group (n = 75) received standard recommendations only. The following was evaluated: time and degree of elimination of fragments; the presence of pain and leukocyturia; recurrent stone formation.
Results. The elimination of fragments was observed up to 14 days in 94.7 % of patients in the main group versus 76 % of patients in the control group. Renal colic was observed in 6.7 % of patients in the main group versus 10.7 % of patients in the control group; cases of leukocyturia were observed within 14 days in 10.7 % versus 22.7 %, respectively. During the year, a recurrent lithiasis was diagnosed in 6.7% of patients in the main group and in 16 % of patients in the control group.
Conclusion. The use of BNO 1040 extract in combination with ESWL: contributes to more rapid and safe elimination of fragments of the calculi and reduces the risk of recurrent stone formation.
Place of Duloxetine in Concervative Treatment Women and Men with Stress Urinary Incontinence
Authors: Gorovyi Viktor , Litvinets Vladyslava , Gurzhenko Olena 
Published: July 2021

History of introduction of duloxetine in medical practice, mechanism of action and using of duloxetine in concervative treatment women and men with stress urinary incontinence are shown. Modern structure of external urethral sphincter in women and men was shown with increasing of sphincter tone under duloxetine influence.
Duloxetine recommended by International Continent Society for initial treatment women with stress urinary incontinence but this drug gives only improvement of urine continence and quality of life with side effects. Duloxetine with connection with pelvic floor muscle training gives better results than using separately duloxetine and pelvic floor muscle training. Nausuea is the most frequency side symptom after using duloxetine. Results of own investigations were shown and indications for using duloxetine in women with stress urinary incontinence were summed up. The most positive results were obtained after combination of duloxetine with pelvic floor muscle training and electrostimulation of urethral sphincter. Duloxetine for treatment men with stress urinary incontinence after radical prostatectomy is only clinical tested. Estimation of efficacy of duloxetine in treatment men with stress urinary incontinence after open prostatectomy due to benign prostatic hyperplasia is needed.
Dutasteride 5α-reductase Inhibitor in the Treatment of Benign Prostatic Hyperplasia: Systematic Review and Meta-analysis
Authors: Romaniuk Maksym , Aksonov Pavlo 
Published: July 2021

Dutasteride is a competitive inhibitor of the enzyme 5-alpha-reductase and is commonly used to treat the symptoms of benign prostatic hyperplasia (BPH).
Objective: to determine the efficacy and safety of dutasteride in terms of indicators that are important in clinical practice.
Data sources. The literature was searched using the search terms «prostate hyperplasia», «prostate hypertrophy», «dutasteride», «quality of life», and «adverse drug reaction». Articles were obtained from Embase, PubMed, the Kokhranov Central Register of Controlled Trials, with a search till December 2020.
Study selection and data recovery. Randomized controlled trials, quasi-randomized trials, and systematic reviews evaluating the efficacy of dutasteride, both in monotherapy and in combination with alpha-blockers for the treatment of men with BPH were included in the analysis. Indicators were the need for prostate surgery, episodes of acute urinary retention, discontinuation of therapy due to side effects, the number of patients who had serious side effects, mortality and sexual dysfunction.
Data analysis. Four studies involving 1,879 patients were evaluated. All studies have shown significant clinical efficacy of dutasteride to the need for prostate surgery, with episodes of acute urinary retention that was higher than finasteride with equal safety profiles.
Conclusion. No statistically significant differences between the two 5AR inhibitors finasteride and dutasteride in terms of safety profile were found, based on the studies included in this system review. This determines the best clinical efficacy of dutasteride in terms of the number of cases of acute urinary retention and the need for surgery.
The Outcomes of an Improved Treatment of Patients with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease
Authors: Mykhalchyshyn Halyna 
Published: July 2021

Nowadays we notice the increase of cases that combine type two diabetes mellitus, and nonalcoholic fatty liver disease. As a result, the course of disease aggravates. The pathogenesis, diagnoses and treatment of NAFLD remain unclear.
The objective: of our study is to determine the clinical efficacy of an improved therapeutic measures set in patients with type 2 diabetes and NAFLD.
Materials and methods. We’ve examined 132 patients with type 2 diabetes mellitus and NAFLD. All patients gave their consent to participate in the study. They also received all necessary nutrition and workout recommendations. We split the patients into two groups. First group patients (n=37) received antihyperglycemic drugs (metformin, gliclazide or glimepiride). Patients of the second group (n=95) additionally received DPP-4 inhibitors (saxagliptin or sitagliptin), atorvastatin, and the multiprobiotic. Patients of the second group were divided into 2 subgroups: 2A group with standard level of transaminases, and 2B group with an increased level of transaminases accordingly.
Results. Improved set of therapeutic measures revealed distinctively positive effect on the dynamics of clinical manifestation of lesions of the hepatobiliary system in patients with diabetes. There were no such changes in another group. Under the influence of complex treatment in the second group of patients, the functional state of liver improved due to a significant decrease of ALT, AST, TG and VLDL levels in the blood serum. Size of the liver decreased, liver stiffness indicators improved according to shear wave elastography data.
Conclusions. Combined therapy, which includes DPP-4 inhibitors, statins and multiperiodic is effective in the treatment of patients with type two diabetes and nonalcoholic fatty liver disease.
Efficacy and Safety for Use Desloratadine in Children with Allergic Conditions (Literature Review, Own Research)
Authors: Marushko Yurii , Khomych Olha 
Published: July 2021

According to scientists, more than 20 thousand allergens are known and their number is constantly increasing. Therefore, children’s allergy remains one of the urgent problems of modern medicine, since allergic diseases in adults in most cases begin from childhood.
The article summarizes our own data and presents a scientific review of the medical literature, which is devoted to the analysis of the problem of treatment of allergic diseases with desloratadine in children. Nowdays there is a significant prevalence of allergic conditions in children. We analyzed the effect of desloratadine on the course of allergic diseases in children. The analyzed literature review showed a high safety profile of the drug desloratadine. Also we presented the personal data of desloratadine therapy for seasonal allergic rhinitis in children.
The literature data presented in the article and our own experience allow us to conclude that allergic conditions remain an urgent problem in clinical medicine, and the use of antihistamines, in particular desloratadine, increases the effectiveness of allergy therapy and accelerates the recovery and disappearance of symptoms.
Comparative efficacy оf non-surgical correction of early-onset genital prolapse based on differentiated approach
Authors: Kaminskyi V.V. , Chaika K.V. , Lavreniuk Yu.V. , Diadyk O.O. , Beketova Yu.I. , Baryshnikova O.P. 
Published: July 2021

The paper presents the results of the comparative efficacy of non-surgical correction of early-onset genital prolapse (GP) in women of perimenopausal and menopausal age using differentiated approach. The objective: to study morphological traits of the vaginal walls and to compare the effectiveness of non-surgical techniques of GP correction. Materials and methods. The study involved 120 patients with early-onset GP. The treatment group (Group 1) consisted of 90 women with GP who were divided into three subgroups depending on the non-surgical correction technique chosen (utility model patent No.145380 from 10.12.2020): 1a (n=30) – GP correction by platelet-rich autoplasma, 1b (n=30) – GP correction by hyaluronic acid-based agent, 1c (n=30) GP correction using СО2 laser radiation. The experimental group (Group 2) consisted of 30 patients who underwent GP correction by training the pelvic floor muscles individually according to the standard method.Results. Three months after the treatment according to the patented method, the number of patients with GP of grade 2 decreased by 16.7% in group 1a, by 31.3% in group 1b and by 41.2% in group 1c. In patients of 1c subgroup, where the presence of the combined type (cystorectocele) of GP prevailed, in 19 women (63.3%) after the treatment there was an improvement in the morphological structure of the vaginal wall, which was manifested by a pronounced diffuse improvement in angiogenesis (in all layers) due to neoangiogenesis, preserved structure of collagen fibers with increasing density of the latter in the absence of signs of edema and mild degenerative changes. It should be noted that in subgroup 1b, three months after the treatment 17 (56.6%) women had no complaints which was associated with a significant improvement in the indicator of the size of elastin and collagen fibers, and only in 9 patients (30%) this indicator remained without changes. In subgroup 1a, the evaluation of the effectiveness of the non-surgical technique showed that only 10 (33.3%) women had a slight improvement in quality of life compared to baseline before treatment. In the experimental group, there was no positive dynamics, and in 9 women (30%) three months after the treatment there was an increase in manifestations of GP and symptoms associated with it, which was confirmed by such morphological changes as minimal focal signs of neoangiogenesis, thinned, significantly swollen collagen fibers, surrounded by interlayers of connective tissue.Conclusions. This algorithmic approach in non-surgical correction of GP contributes not only to the effective treatment of early-onset GP, prevention of further progression, but also to a significant improvement in quality of life.
Yemeklik Baklagil Tohumlarıyla Taşınan Bazı Virüslerin Tespiti, Biyolojik ve Moleküler Karakterizasyonu
Authors: KIZMAZ Mehmet Zeki , GÜMÜŞ Mustafa 
Published: July 2021

Bu çalışma, 2017 yılında Türkiye’nin farklı illerindeki üreticilerden ve firmalardan temin edilen bakla, bezelye, mercimek ve nohut tohum örneklerinde Alfalfa mosaic alfamovirus (AMV), Bean yellow mosaic potyvirus (BpYMV), Cucumber mosaic cucumovirus (CMV) ve Pea seed-borne mosaic potyvirus (PSbMV) virüslerinin bulunma durumunun belirlenmesi ve tespit edilen virüslerin biyolojik ve moleküler karakterizasyonunun yapılması amacıyla gerçekleştirilmiştir.
Tohum örneklerinde virüslerin saptanmasında, DAS-ELISA ve RT-PCR yöntemleri kullanılmıştır. Tespit edilen virüsler mekanik inokulasyonla test bitkilerine taşınarak biyolojik karakterizasyonu yapılmıştır. Daha sonra RT-PCR yöntemiyle çoğaltılan virüslerin CP gen bölgelerinin dizi analizleri yapılarak, MEGA programı vasıtasıyla dünya izolatlarıyla karşılaştırılmalı olarak filogenetik analizi gerçekleştirilmiştir.
Bakla, mercimek ve nohut tohum örneklerinde virüslere rastlanırken, bezelye tohumlarında herhangi bir virüse rastlanmamıştır. Baklada PSbMV, Nohutta BYMV, CMV ve PSbMV virüsleri ülkemizde ilk kez belirlenmiştir. Biyolojik karakterizasyon çalışmalarında, AMV, BYMV, CMV ve PSbMV izolatları dünya izolatlarıyla farklılıklar ve benzerlikler göstermiştir. Ayrıca, dünya izolatlarıyla yüksek oranda nükleotit ve aminoasit benzerliği tespit edilmiştir.
Leak Detection in Pipelines Using Wavelet Transform and Cepstrum Analysis Methods
Authors: Gigih Priyandoko , Ghazali Mohd Fairusham 
Published: July 2021

Nowadays, a piping system is one of the important features in either home or industrial user. Leak in piping systems is a major operational problem around the world. Leaks result to loss in the fluid through the flow and automatically affect to the economy of the user. Objective of this research is utilizing the signal processing using Wavelet Transform and Cepstrum Analysis methods to leak detect in pipeline. After experiment has been completed, the data analysis process by using Matlab Software takes place. The result shows that the accuracy of the leak location detection is accurate with small error results below 10%.
Mabnīyāt al-Asmā’ (Dirāsah Tahlīlīyah Thatbīqīyah fī Sūrati al-Naba’)
Authors: Saleh Sriwahyuningsih , Doni Chaterina P 
Published: July 2021

Penelitian ini membahas tentang isim-isim yang mabny (Mabnīyāt al-Asmā’) dalam surah al-Nabah, yang dianalisis dengan pendekatan ilmu Nahwu. Dalam penelitian ini dianalisis dua pokok masalah penelitian yaitu; 1) mengidentifikasi yata-ayat dalam surah al-Nabah yang di dalamn ya terdapay isim mabniy (mabnīyāt al-asmā), 2) bagaimana ‘irab dari isim-isim yang mabni dalam surah al-Naba. Metode penelitian yang digunakan adalah metode analisis deskriptif dengan jenis penelitian kajian pustaka. Hasil penelitian menunjukkan bahwa ayat-ayat yang di dalamnya terdapat mabnīyāt al-asmā dalam surah al-Naba’ adalah 14 ayat terdiri dari Dhamir (kata ganti), ism al-isyarah 1 ayat, ism al-Maushul 1 ayat, ism syat 1 ayat, ism istifham 2 ayat dan al-Dzharf 1 ayat.
More on the Influence of Injector Geometry and Carrier Gas Flow Rate on Spray Pattern and Particle Temperature
Authors: Fincke J.R. , Swank W.D. , Haggard D.C. 
Published: July 2021

Abstract
Recently it has been suggested that the carrier gas jet interaction with the plasma can have a large effect on the resulting particle temperature. The postulated interaction is through deflection of the main plasma jet and by delaying the heating of particles by the formation of a "cold" gas bubble. We have examined the effect of the gas jet itself on the temperature of the particles by attempting to artificially form a cold gas bubble using a separate, closely oriented gas jet. The effect of the "twin" co-flowing jet was evaluated by measuring its effect on the mean and standard deviation of the particle injection velocity and the resulting spray pattern and particle temperature. Additionally we have used alternative carrier gases with similar density but with specific heats that are higher than argon by a factor of two. A measurable but minor effect on particle temperature is observed.