bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stretchable and Highly Permeable Nanofibrous Sensors for Detecting Complex Human Body Motion
Authors: Horev Yehu David , Maity Arnab , Zheng Youbin , Milyutin Yana , Khatib Muhammad , Yuan Miaomiao , Suckeveriene Ran Yosef , Tang Ning , Wu Weiwei , Haick Hossam 
Published: August 2021

AbstractWearable strain sensors have been attracting special attention in the detection of human posture and activity, as well as for the assessment of physical rehabilitation and kinematics. However, it is a challenge to fabricate stretchable and comfortable‐to‐wear permeable strain sensors that can provide highly accurate and continuous motion recording while exerting minimal constraints and maintaining low interference with the body. Herein, covalently grafting nanofibrous polyaniline (PANI) onto stretchable elastomer nanomeshes is reported to obtain a freestanding ultrathin (varying from 300 to 10 000 nm) strain sensor that has high gas permeability (10–33 mg h–1). The sensor demonstrates a low weight and can be directly laminated onto the dynamic human skin for long periods of time. The sensor, which produces an intimate connection with solid or living objects, has a stable performance with excellent sustainability, linearity, durability, and low hysteresis. It exibits excellent performance for continuous interrogation of complex movements, mimicking muscle activities, and resembling brain activity. This includes a very precise discrimination of bending and twisting stimuli at different angles (1–180°) and speeds (3–18 rpm) and very low exertion of counter‐interference. These results imply the utility of this appraoch for advanced developments of robotic e‐skins or e‐muscles.
A Powerful One‐Step Puffing Carbonization Method for Construction of Versatile Carbon Composites with High‐Efficiency Energy Storage
Authors: Shen Shenghui , Huang Lei , Tong Xili , Zhou Rongfan , Zhong Yu , Xiong Qinqin , Zhang Lingjie , Wang Xiuli , Xia Xinhui , Tu Jiangping 
Published: August 2021

AbstractCarbon materials play a critical role in the advancement of electrochemical energy storage and conversion. Currently, it is still a great challenge to fabricate versatile carbon‐based composites with controlled morphology, adjustable dimension, and tunable composition by a one‐step synthesis process. In this work, a powerful one‐step maltose‐based puffing carbonization technology is reported to construct multiscale carbon‐based composites on large scale. A quantity of composite examples (e.g., carbon/metal oxides, carbon/metal nitrides, carbon/metal carbides, carbon/metal sulfides, carbon/metals, metal/semiconductors, carbon/carbons) are prepared and demonstrated with required properties. These well‐designed composites show advantages of large porosity, hierarchical porous structure, high conductivity, tunable components, and proportion. The formation mechanism of versatile carbon composites is attributed to the puffing‐carbonization of maltose plus in situ carbothermal reaction between maltose and precursors. As a representative example, Li2S is in situ implanted into a hierarchical porous cross‐linked puffed carbon (CPC) matrix to verify its application in lithium–sulfur batteries. The designed S‐doped CPC/Li2S cathode shows superior electrochemical performance with higher rate capacity (621 mAh g–1 at 2 C), smaller polarization and enhanced long‐term cycles as compared to other counterparts. The research provides a general way for the construction of multifunctional component‐adjustable carbon composites for advanced energy storage and conversion.
Antibacterial Gel Coatings Inspired by the Cryptic Function of a Mussel Byssal Peptide
Authors: Fichman Galit , Andrews Caroline , Patel Nimit L. , Schneider Joel P. 
Published: August 2021

AbstractAlthough the adhesive and cohesive nature of mussel byssal proteins have long served to inspire the design of materials embodying these properties, their characteristic amino acid compositions suggest that they might also serve to inspire an unrelated material function not yet associated with this class of protein. Herein, it is demonstrated that a peptide derived from mussel foot protein‐5, a key protein in mussel adhesion, displays antibacterial properties, a yet unreported activity. This cryptic function serves as inspiration for the design of a new class of peptide‐based antibacterial adhesive hydrogels prepared via self‐assembly, which are active against drug‐resistant Gram‐positive bacteria. The gels exert two mechanisms of action, surface‐contact membrane disruption and oxidative killing affected by material‐produced H2O2. Detailed studies relating amino acid composition and sequence to material mechanical adhesion/cohesion and antibacterial activity affords the MIKA2 adhesive gel, a material with a superior activity that is shown to inhibit colonization of titanium implants in mice.
All Paper‐Based, Multilayered, Inkjet‐Printed Tactile Sensor in Wide Pressure Detection Range with High Sensitivity
Authors: Lee Taehoon , Kang Yunsung , Kim Kwanhun , Sim Sangjun , Bae Kyubin , Kwak Yeunjun , Park Wonkeun , Kim Minhyeong , Kim Jongbaeg 
Published: August 2021

AbstractPaper has attracted considerable interest as a promising pressure‐sensing element owing to its foldability/bendability and deformability due to its high porosity. However, paper‐based tactile sensors reported hitherto cannot achieve high sensitivity and a wide sensing range simultaneously. In this study, a resistive tactile sensor using carbon nanotube‐ and silver nanoparticle‐printed mulberry paper as a pressure‐sensing element and electrodes, respectively, is developed. The rough surface and high inner porosity of mulberry paper induce a significant change in the contact area when a multilayer‐stacked structure is used, resulting in increased sensitivity to pressure. Moreover, the enhanced mechanical robustness of mulberry paper originating from the highly bonded network of long and thick fibers affords a wide pressure‐sensing range. The sensor exhibits a high sensitivity exceeding 1 kPa−1 in an applied pressure range of 0.05–900 kPa; this achievement has not been reported among paper‐based tactile sensors. Furthermore, the sensor exhibits a fast response/relaxation time, low detection limit, high resolution, high durability, and high flexibility. The advantages of the sensor afford several applications, including a crosstalk‐free pressure sensor array, a three‐axis pressure sensor, and wearable devices for measuring signals from a user.
Multifunctional Chemical Sensing Platform Based on Dual‐Resonant Infrared Plasmonic Perfect Absorber for On‐Chip Detection of Poly(ethyl cyanoacrylate)
Authors: Li Dongxiao , Zhou Hong , Hui Xindan , He Xianming , Huang He , Zhang Jiajia , Mu Xiaojing , Lee Chengkuo , Yang Ya 
Published: August 2021

AbstractMultifunctional chemical sensing is highly desirable in industry, agriculture, and environmental sciences, but remains challenging due to the diversity of chemical substances and reactions. Surface‐enhanced infrared absorption (SEIRA) spectroscopy can potentially address the above problems by ultra‐sensitive detection of molecular fingerprint vibrations. Here, a multifunctional chemical sensing platform based on dual‐resonant SEIRA device for sensitive and multifunctional on‐chip detection of poly(ethyl cyanoacrylate) (PECA) is reported. It is experimentally demonstrated that the SEIRA sensing platform achieves multiple functions required by the PECA glue industry, including vibrational detection, thickness measurement, and in situ observation of polymerization and curing, which are usually realized by separately using a spectrometer, a viscometer, and an ellipsometer in the past. Specifically, the all‐in‐one sensor offers a dual‐band fingerprint vibration identification, sub‐nm level detection limit, and ultrahigh sensitivity of 0.76%/nm in thickness measurement, and second‐level resolution in real‐time observation of polymerization and curing. This work not only provides a valuable toolkit for ultra‐sensitive and multifunctional on‐chip detection of PECA, but also gives new insights into the SEIRA technology for multi‐band, multi‐functional, and on‐chip chemical sensing.
Evaluating salinity tolerance in progeny of domestic and wild barley crosses at germination stage
Authors: Mohammed Abdullah Hassn , Morrison Jesse I. , Baldwin Brian S. 
Published: August 2021

AbstractSalinity is one of the most important challenges facing future global barley (Hordeum vulgare L.) productivity, as it causes major reduction in germination, growth, grain yield, and quality. Screening germplasm for salinity tolerance at germination is vital to breeding programs because germination is the first stage of plant growth and occurs near the soil surface where salt can accumulate in high concentrations. This experiment was conducted to assess salinity tolerance of 249 genotypes (64 diploid (2×) H. vulgare crosses; 174 tetraploid (4×) H. vulgare crosses; and 11 parents) at the seed germination stage. Salinity treatments applied at imbibition included concentrations of 0, 100, 200, and 300 mM salinity and were maintained for 10 d. Analysis of variance of all families indicated significant (P ≤ .001) genotype × salinity interaction for final germination percentage (FG%), corrected germination percentage (CG%), and germination index (GI) at all treatment levels, indicating high genetic variation for salinity tolerance among screened genotypes. The mean of all measured parameters (FG%, CG%, and GI) decreased as salinity concentration increased. These responses can be used to identify genotypes with salinity tolerance at germination. At 300 mM salinity, progenies in 2× Families 1 and 2 were 14.3 and 12.5% saline tolerant, respectively. A total of 29 progenies from 4× families were tolerant to 300 mM treatment at germination. These progenies would have an economic value for improving barley tolerance for salinity.
Perspectives of Region XI Head Start Federal, Research, and Program Partners in Carrying out a National Study of American Indian and Alaska Native Head Start Children, Families, and Programs
Authors: Sarche Michelle , Malone Lizabeth M. , Hoard Laura , Barnes‐Najor Jessica , Cameron Ann , West Jerry , Barofsky Meryl ,   The AIAN FACES Workgroup
Published: August 2021

AbstractThe American Indian and Alaska Native Head Start Family and Child Experiences Survey (AIAN FACES) 2015 was the first national study of children served by Region XI Head Start programs, which are those operated by federally recognized AIAN tribes. Until 2015, Region XI programs had not been included in national studies of Head Start children’s experiences and development, leaving them without this critical source of data to inform policy and practice as is available to other Head Start regions. To address this gap, four groups of stakeholders gathered to plan for a study that put the needs of Region XI Head Start at the forefront, was informed by the historical context of research with AIAN communities, and was guided by community psychology and community‐based and tribal participatory approaches. Engaged partnership is a common practice in research with AIAN communities, but rarely on a national scale across diverse communities. The study’s success speaks to the success of the unique national partnership between the Region XI Head Start, research, and federal stakeholders who formed the AIAN FACES Workgroup. This first‐person account documents the perspective of each group as they undertook this seminal effort and reviews connections with, and lessons learned for, the broader field of community psychology.
Toward better characterization of restricted and repetitive behaviors in individuals with germline heterozygous PTEN mutations
Authors: Uljarević Mirko , Frazier Thomas W. , Rached Gaëlle , Busch Robyn M. , Klaas Patricia , Srivastava Siddharth , Martinez‐Agosto Julian A. , Sahin Mustafa , Eng Charis , Hardan Antonio Y. ,   Developmental Synaptopathies Consortium
Published: August 2021

AbstractThis study aimed to further our understanding of restricted and repetitive behaviors (RRB) among individuals with germline pathogenic mutations in PTEN by providing multimethod characterization and comparison of key RRB subdomains across individuals with PTEN mutations with autism spectrum disorder (ASD) (PTEN‐ASD), with PTEN mutations without ASD (PTEN‐No ASD) and with ASD and macrocephaly but without PTEN mutations (Macro‐ASD). Of 86 total research participants, 38 had PTEN‐ASD (Mage = 8.93 years, SDage = 4.75), 25 Macro‐ASD (Mage = 11.99 years; SDage = 5.15), and 23 PTEN‐No ASD (Mage = 8.94 years; SDage = 4.85). The Repetitive Behavior Scale‐Revised (RBS‐R) and the Autism Diagnostic Interview‐Revised (ADI‐R) were used as measures of distinct RRB domains. There were significant group differences in the RBS‐R repetitive motor behaviors (RMB; F = 4.52, p = 0.014, ω2 = 0.08), insistence on sameness (IS; F = 4.11, p = 0.02, ω2 = 0.05), and circumscribed interests (CI; F = 7.80, p = 0.001, ω2 = 0.14) scales. Post hoc comparisons showed that the PTEN‐No ASD group had significantly lower RMB, IS, and CI scores compared to both PTEN‐ASD and Macro‐ASD groups. Importantly, PTEN‐No ASD group still showed elevated RRB levels. Furthermore, there was a portion of individuals in PTEN‐No ASD group whose Full‐Scale Intelligence Quotient (FSIQ) was >70 that did not show floor level scores in the RMB domain. After adjusting for age and FSIQ scores, group differences were no longer statistically significant. RMB, IS, and CI domains showed distinct association patterns with sex, age, and FSIQ. This investigation provides the largest and most comprehensive characterization of distinct RRB domains in individuals with PTEN mutations to date. Despite the limitations, our findings have important assessment and treatment implications.
Preparation and performance of poly (vinyl alcohol)/polylactic acid/hydroxyapatite composite scaffolds based on 3D printing
Authors: Peng Biyou , Li Jiawen , Wu Jintian , Chen Ning , Chen Gang 
Published: August 2021

AbstractPreparation of biological scaffolds with complex shapes and controllable internal structures is a significant development direction for the tissue engineering field. Due to its simplicity, low‐cost and cost‐effectiveness, fused deposition molding (FDM) is one of the most popular 3D printing technologies. In this paper, polyvinyl alcohol/polylactic acid/hydroxyapatite composites were fabricated successfully. On this basis, composite scaffolds with different pore structures were designed and constructed by using FDM technology. The material structure was characterized by scanning electron microscopy (SEM) and dynamic thermomechanical analyzer. The results showed that the cross‐sectional morphology of the system presented a “sea‐island” structure. The introduction of PLA and HA significantly increased the modulus of the material, which was beneficial to achieve its FDM processing. The compressibility, mineralization behavior, and biocompatibility of the viscoelastic characteristics to natural cartilage subjected to the condition of filling angle of 45° was systemically invesitgated. Notably, the concentrations of Ca2+and PO43−in simulated body fluid were reduced by 34.7% and 58.2% on 8th day, indicating a good bone formation and mineralization ability, which was further corroborated by SEM and fourier‐transform infrared spectroscopy (FTIR) results. Biotoxicity test showed that the scaffold presented excellent biocompatibility.
Gold Nanoparticle‐based “Mix and Measure” Fluorimetric Assays to Quantify Antibody Titer
Authors: Sutarlie Laura , Siak‐Wie Ow Dave , Kong Ng Say , Yang Yuansheng , Su Xiaodi 
Published: August 2021

AbstractMonoclonal antibodies (mAbs) for treatment of human diseases are typically human or humanized Immunoglobulin G (IgG) produced in mammalian cell lines. A rapid, less tedious, and high throughput method to quantify mAbs is in demand to accelerate mAb production efficiency. To quantify mAb titer, we developed gold nanoparticle (AuNPs)‐based “mix and measure” fluorimetric assays by exploiting AuNPs’ fluorescence quenching ability. The AuNPs are functionalized by an Fc binding protein, i. e. protein G, which binds human IgG and fluorescently labeled rat IgG (Alexa Fluor 488‐rat IgG) with differential affinity. The assays can be in competition or displacement format. The competitive binding of human IgG drug and the labelled rat IgG to protein G‐coated AuNP lead to varied fluorescent intensity that is proportional to the amount of human IgG analte; or the displacement of the labelled rat IgG from protein G‐coated AuNP by human IgG can lead to fluorescent recovery that is also proportionally related to human IgG concentration. The assays can quantify therapeutic mAbs in the range of 10–1,000 mg/L, demonstrated for Herceptin, Avastin, and Humira in cell culture media. The assays have fast turn over time (within 15 min). They can be performed in microplates and are suitable for high throughput “on‐line” or “at‐line” measurement in mAbs production lines.
Modulation of H3.3 chromatin assembly by PML: A way to regulate epigenetic inheritance
Authors: Delbarre Erwan , Janicki Susan M. 
Published: August 2021

AbstractAlthough the promyelocytic leukemia (PML) protein is renowned for regulating a wide range of cellular processes and as an essential component of PML nuclear bodies (PML‐NBs), the mechanisms through which it exerts its broad physiological impact are far from fully elucidated. Here, we review recent studies supporting an emerging view that PML's pleiotropic effects derive, at least partially, from its role in regulating histone H3.3 chromatin assembly, a critical epigenetic mechanism. These studies suggest that PML maintains heterochromatin organization by restraining H3.3 incorporation. Examination of PML's contribution to H3.3 chromatin assembly in the context of the cell cycle and PML‐NB assembly suggests that PML represses heterochromatic H3.3 deposition during S phase and that transcription and SUMOylation regulate PML's recruitment to heterochromatin. Elucidating PML’ s contributions to H3.3‐mediated epigenetic regulation will provide insight into PML's expansive influence on cellular physiology and open new avenues for studying oncogenesis linked to PML malfunction.
Prospective observational study of young adult ischemic stroke patients
Authors: Shihmanter Renata , Friedman Joshua , Kushner Natali , Miller Edward B. , Schattner Ami 
Published: August 2021

AbstractObjectiveIschemic stroke (IS) in young patients may differ in etiology and prognosis from later‐life IS, which is much more common. A number of single‐center and population‐based cohorts of affected individuals have been published, but information on the long‐term prognosis of these patients is limited.MethodsIS patients (≤55 years), discharged over a 10‐year period, were evaluated and prospectively followed. Subgroups were evaluated for type of stroke, antecedent risk factors (RF), long‐term outcomes, and occupational status over several years of follow‐up.Results178 IS individuals from 2001–2010 were divided into older (46–55, n = 118) and younger (18–45, n = 60) age groups. Traditional RF—hypertension, diabetes mellitus, hyperlipidemia—were significantly associated with IS, and increased with age. The distribution and type of IS were similar in both groups, except for an increase in small vessel IS among the older subgroup (p = .003).Of the evaluable patients at 5.1 ± 2.5 years of follow‐up (n = 138), a similar proportion of patients in both subgroups had a recurrent IS, but no significant differences were found in most disability indices. Approximately one third of patients suffered from moderate to severe disability, and were unable to return to their prior work.ConclusionsYounger and older IS patients are generally predisposed from the same traditional RF which progress with age. Long‐term disabilities tend to worsen over time due to recurrent vascular events. These data emphasize the need for a strategy for early identification of the already well‐known stroke RF in younger stroke patients.
Prognostic significance of programmed cell death‐ligand 1 expression on circulating tumor cells in various cancers: A systematic review and meta‐analysis
Authors: Ouyang Yushu , Liu Wendao , Zhang Ningning , Yang Xiaobing , Li Jinwei , Long Shunqin 
Published: August 2021

AbstractBackgroundThe prognostic significance of programmed cell death‐ligand 1 (PD‐L1) expression on circulating tumor cells (CTCs) has been explored but is still in controversy. We performed, for the first time, a meta‐analysis to systematically evaluate its prognostic value in human cancers.MethodsLiterature databases were searched for eligible studies prior to June 30, 2021. The pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated for the associations of pre‐treatment and post‐treatment PD‐L1+ CTCs with progression‐free survival (PFS) and overall survival (OS). Subgroup analyses with regards to cancer type, treatment, CTC enrichment method, PD‐L1 detection method, cut‐off, and specifically the comparison model were performed.ResultsWe included 30 eligible studies (32 cohorts, 1419 cancer patients) in our analysis. Pre‐treatment PD‐L1+ CTCs detected by immunofluorescence (IF) tended to predict better PFS (HR = 0.55, 95% CI 0.28–1.08, p = 0.084) and OS (HR = 0.61, 95% CI 0.36–1.04, p = 0.067) for immune checkpoint inhibitor (ICI) treatment, but were significantly associated with unfavorable survival for non‐ICI therapies (PFS: HR = 1.85, 95% CI 1.21–2.85, p = 0.005; OS: HR = 2.44, 95% CI 1.69–3.51, p < 0.001). Post‐treatment PD‐L1+ CTCs predicted markedly worse PFS and OS. The prognostic value was obviously modulated by comparison models. Among patients with detectable CTCs, PD‐L1+ individuals had comparable survival to PD‐L1− individuals, except ICI treatment for which PD‐L1+ may predict better PFS (HR = 0.42, 95% CI 0.17–1.06, p = 0.067). Patients with PD‐L1+ CTCs had worse survival prognosis compared to those without PD‐L1+ CTCs in overall analysis (PFS: HR = 2.10, 95% CI 1.59–2.77, p < 0.001; OS: HR = 2.55, 95% CI 1.70–3.81, p < 0.001) and in most subgroups.ConclusionsOur analysis demonstrated that PD‐L1 positive expression on CTCs predicted better survival prognosis for ICI treatment but worse survival for other therapies, which thus can be potentially used as a prognostic marker of malignant tumor treatment. However, the prognostic value of PD‐L1+ CTCs for ICI treatment needs validation by more large‐scale studies in the future.
A novel biallelic LMNB2 variant in a patient with progressive myoclonus epilepsy and ataxia: A case of laminopathy
Authors: Farajzadeh Valilou Saeed , Karimzad Hagh Javad , Salimi Asl Mohammad , Abdi Rad Isa , Edizadeh Masoud , Pooladi Arash 
Published: August 2021

AbstractThe report of LMNB2‐related progressive myoclonus epilepsy and ataxia due to missense homozygous c.473G>T variant.