bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the efficacy of trauma scores in predicting prognosis and hospitalization
Authors: AKÇA Hatice Şeyma , ALGIN Abdullah , ÖZDEMİR Serdar , KOÇKARA Elif , EROĞLU Serkan Emre 
Published: December 2021

Purpose: The aim of this study was to compare the efficacy of ISS (injury Severity Score), RTS (Revised Trauma Score) and ViEWS (VitalPAC Early Warning Score) scoring systems in predicting prognosis and mortality.
Materials and Methods: Patients over the age of 18 who presented with multitrauma were prospectively examined between May 1, 2019 and November 1, 2019. Trauma scores, clinical outcomes within the first 24 hours, surgery requirement and 30-day mortality data were recorded.
Results: The study included 435 patients, of whom 333 (76.6%) were male. The median age was 34 (IQR: 18-90) years. It was observed that ISS, RTS and ViEWS had a significant relationship with 30-day mortality. In the ROC analysis of 30-day mortality, no statistically significant difference was observed between the ISS, RTS, and ViEWS AUC values. There was also no statistically significant difference in terms of the ISS, RTS and ViEWS according to the length of hospital stay and surgery requirement.
Conclusion: In addition to their relationship with mortality, it should be kept in mind that the investigated scoring systems may also be related to the length of hospital stay and surgery requirement.
Persistent Eustachian valve and transient arterial hypoxemia in a newborn: a clinical observation
Authors: Tarayan M. V. , Drozdova I. A. , Bondareva I. O. , Efremov E. S. , Vishnyakova M. V. 
Published: December 2021

The Eustachian valve (EV) is located in the orifice of inferior vena cava and belongs to structures of the normal heart. It plays an important role in the fetal blood flow by directing the flow of blood from inferior vena cava through an open foramen ovale to the left atrium, thereby ensuring the systemic flow in a fetus and bypassing the pulmonary circulation. After birth and upon closure of the foramen ovale, the valve ceases to function and tends to regress. Usually, a prominent EV is a clinically non-significant ultrasound finding. In isolated cases, however, it can cause significant hemodynamic abnormalities and subsequent rhythm disorders, delayed fetal development and transient hypoxemia in newborns. It can extremely rare be a cause of blood right-toleft shunting through the foramen ovale leading to desaturation. Clinically it can manifest by central cyanosis in newborns and infants. The differential diagnosis is made in neonatal intensive care units. We present a case of transient arterial hypoxemia in a newborn with prominent EV and inter-atrial shunt. A one-month old infant was transferred from the Department of Pediatric Cardiology with a history of transient hypoxemic spells related to right-to-left shunting via atrial septal defect caused by obstruction of the tricuspid valve by the prominent EV. The instrumental findings including contrast-enhanced tomography supported this hypothesis. The patient was stable for subsequent 10 days of the follow-up, which allowed for further conservative managements until the conventional time point for children with an atrial septal defect. Potential regress of the prominent EV, as well as natural growth of an infant and his/hers intracardiac structures, provide mostly favorable outcome without a surgical intervention. This was clearly illustrated in the clinical case.
Unbalanced atrioventricular septal defect with dominant right ventricle: diagnostic criteria, indications for biventricular correction, and results. A clinical observation series
Authors: Didyk V. P. , Belov V. A. , Bukhareva O. N. , Laryutina O. A. ,  Akobyan T. L. , Kharsika A. A. , Makarov A. A. , Schneider Yu. A. 
Published: December 2021

Relevance: Surgical treatment for congenital heart disease (CHD) with borderline left ventricle (LV) dimensions is one of the most challenging issues in current pediatric cardiac surgery. Despite the prevailing general trend to the expansion of indications for biventricular repair of an unbalanced atrioventricular septal defect (AVSD) with a dominant right ventricle (RV), the diagnostic criteria for imbalance, feasibility of radical repair and its functional results are intensively discussed in the literature.Aim: To present quantitative criteria for the assessment of the LV size which could serve as an indication for biventricular repair of the right dominant unbalanced AVSD.Materials and methods: We present a series of 4 patients with AVSD and dominant RV, who underwent radical repair of the defect. The mean age of the patients was 2.4 years, and 3 of 4 had concomitant CHD: tetralogy of Fallot, double outlet right ventricle with pulmonary artery stenosis, and moderate hypoplasia of the aortic arch with subaortic stenosis. Three of 4 patients had previously undergone palliative interventions: two of them – pulmonary bending, one, the first stage of univentricular repair (atrioseptostomy, cavopulmonary anastomosis). Two children had been diagnosed with Down syndrome. The mean left ventricular end diastolic diameter (LVEDD) at baseline was 17.9 mm, corresponding to Z score of -5.4.Results: All four patients underwent biventricular repair of the defect with a two-patch technique. In one case, it was supplemented with placement of the pulmonary trunk homograft prosthesis, in the other with pulmonary valve commissurotomy and cavopulmonary anastomosis due to moderate tricuspid valve stenosis and in the third case the mitral valve was replaced. In 3 patients pacemaker implantation was performed. The criterion for feasibility of complete septation was the ratio of the longitudinal dimensions of the left and right ventricles (LAR > 0.7), confirmed by computed tomography performed before the surgery. The mean LVEDD after surgery was 28.3 mm, corresponding to Z score of -0.8. At the time of the hospital discharge, the left and right atrioventricular valves insufficiency did not exceed 2 and 1 degrees, respectively.Conclusion: Computed tomography allows for accurate measurement and comparison of the longitudinal dimensions of the heart ventricles with LAR index as a tool for assessment of the LV size before the biventricular repair. An additional prospective study is required to objectify the data obtained and identify predictors of an unfavorable outcome of radical repair in patients with right dominant unbalanced AVSD.
The choice of the insulin basal rate regimen at initiation of insulin pump therapy in routine clinical practice
Authors: Barsukov I. A. , Demina A. A. , Dreval A. V. 
Published: December 2021

Background: Numbers of patients with diabetes mellitus using insulin pumps have been increasing every year. Successful achievement of glycemic targets with continuous subcutaneous insulin infusion (CSII) is based on an adequate basal rate of infusion, carbohydrate coefficient and insulin sensitivity index. There are two approaches to basal insulin infusion rate, namely the flat one and the circadian; however, at present there is no convincing data on which one should be chosen at the start of insulin pump therapy.Aim: To compare two regimens of basal insulin infusion rate at initiation of insulin pump therapy in routine clinical practice.Materials and methods: We analyzed data from 120 patients with Type 1 diabetes mellitus, who were switched on insulin pump therapy in the Department of Endocrinology from 2017 to 2018. At initiation of CSII, 60 patients used the flat basal rate profile and the other 60 patients used the circadian basal rate, calculated with the Renner's scale. Safety of the two basal rate regimens was assessed based on glucose variability measured with continuous glucose monitoring during the first two days after the start of insulin pump therapy.Results: Mean (± SD) coefficients of variation in the groups with circadian and flat basal rate at Day 1 were 31.06±12.13 and 32.74±10.7, respectively (p=0.423); at Day 2, 26.78±11.27 and 28.83±10.7 (p=0.309). Median [Q1; Q3] areas under glucose curve (AUC) values above the glucose targets in the groups with circadian and flat basal rate at Day 1 were 0.37 [0.03; 0.89] and 0.48 [0.08; 1.75], respectively, at Day 2 0.44 [0.03; 1.57] and 0.31 [0.1; 1.5], respectively (p>0.05). Median glucose AUC values below the goal in groups with circadian basal rate and flat basal rate on the first day were 0.01 [0; 0.06] and 0.02 [0; 0.1], respectively (p=0.855), on the second day – 0.00 [0; 0.01] and 0.00 [0; 0.02], respectively (р=0.085). We also haven’t found any between-group differences in the prevalence of glucose deviations below and above the target, as well as in the time spent in normoglycaemia.Conclusion: The comparative analysis of two basal insulin rate regimens in Type 1 diabetic patients switched to insulin pump therapy has shown no significant differences between them. The use of Renner’s scale has no clinical advantages over the fixed basal insulin regimen at initiation of insulin pump therapy in adults.
Case Presentation - Biventricular Hypertrophy and Valvular Pulmonary Stenosis in Adult Patient with Noonan Syndrome: A Rare Case
Authors: Pristianto Tinton , Fagi Rosi Amrilla 
Published: December 2021

Introduction: Noonan syndrome (NS) is a genetic disorder often accompanied by multiple congenital abnormalities. The prevalence of NS at live birth has been reported as one in 1000-2500 individuals. About 80% of patients with Noonan syndrome have abnormalities in the cardiovascular system.Case presentation:41-year-old Javanese male presented with chief complaint shortness of breath. His Body Mass Index (BMI) was 18,3. He had an oval-shaped face with a short neck, thin hair, and prominent nasolabial fold. Echocardiography showed biventricular hypertrophy alongside pulmonary valve stenosis, pulmonary regurgitation and minimal pericardial effusion. Discussion: In 1962, Jacqueline Noonan, a pediatric cardiologist, identified 9 patients whose faces were very similar, had short stature, significant chest deformities, and with pulmonary stenosis. Noonan syndrome is a relatively common non-chromosomal syndrome that is similar to the phenotype of Turner's syndrome and presents with cardiovascular malformations. Adult with NS has distinctive facial features such as ptosis, wide eyes, low posterior rotation of ears and helical thickening, and a wide neck.Pulmonary stenosis is the most common heartdefect found in NS, besides HCM isalsoquitecommon inabout20% of patients. We reported a case of a patient with typical characteristics of NS such as pulmonary valve stenosis accompanied by biventricular ventricular hypertrophyand its typical face who survived through adulthood.Conclusion: Syndrome Noonan in the adult is quite rare and difficult to diagnose. We reported a case of an adult man with facial appearance and echocardiographic findings identical with Noonan Syndrome.
Potential Biomarkers as Early Detection of Diabetic Cardiomyopathy
Authors: Hariadi Hariadi , Giani Maia Thalia , Anggraeni Silvia Handika 
Published: December 2021

Abstract: Diabetes mellitus (DM) is one of the most prevalent and burdensome among chronic disease worldwide. Its complications accelerate mortality rate within population. Diabetic cardiomyopathy (DCM) is one of diabetes macrovascular complications, which symptoms are frequently unforeseen. Advances in pathogenesis understanding DCM underlying mechanisms remain not fully perceived. Current diagnostic approach of DCM can hardly determine diabetic patients with asymptomatic cardiomyopathy. Previous studies suggested biomarkers might detect early stage DCM. There are numerous selective biomarkers representing several pathophysiological pathways, such as myocardial fibrosis, inflammatory response, cardiomyocyte apoptosis, and metabolic dysregulation in the development of diabetic heart anomaly It was also reported those biomarkers are useful for the prognostic assessment of the disease. However, not all biomarkers are cardiac specific and can be an auspicious diagnostic tool candidate. Recent studies show that there are certain biomarkers, such as microRNA, H-FABP, IGFBP7, and some other novel cardiac biomarkers were more specifically associated with the pathological mechanism of DCM. In this review, we aimed to discuss the role of several potential cardiac biomarkers as early detection in DCM that may predict future incident of DCM, and contribute to improving mortality prediction in patients with subclinical DCM.Keywords: Biomarker; Diabetic Cardiomyopathy
The Effect of Maternal Vitamin D Status on Fetal Growth and Stunting: A Systematic Review
Authors: Karmali Nareesa , Blake Kanisha , Olivers Brownmagnus , Ekejiuba Sussan , Azuine Romuladus 
Published: December 2021

Background and Objective: Impaired fetal growth and stunting remain immense public health problems involving maternal nutrition during pregnancy, as linear growth failure in children is the most common form of undernutrition across the world. Although both are preventable through adequate prenatal care and nutrition, impaired fetal growth and stunting continue to be implicated in multiple child health morbidities, physical, and psychological functioning. Recent knowledge and requirements for normal fetal and neonatal development are lacking. This systematic review investigates the effects of maternal vitamin D status on fetal growth and stunting.
Methods: We reviewed three widely-used publications databases: the National Institutes of Health’s PubMed, Clarivate Analytics’ Web of Science, and Google Scholar using pre-established inclusion and exclusion criteria and keyword search strategy. Studies from 2010 to 2020 were included if they reported vitamin D levels on pregnant women, indicated growth outcomes and used quantitative measurements. We excluded non-English language studies, studies with ambiguous outcomes, studies that did not specify vitamin D intake, and studies that involved other maternal health complications. The search was implemented using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Results: Out of a total of 2,481 studies reviewed, we identified 8 studies on vitamin D and fetal growth and stunting. Published literature addressing maternal vitamin D status on fetal growth and stunting remains ambiguous. Five studies demonstrated improvements in fetal and humerus z-scores, which are known proxies for fetal growth, in groups with higher vitamin D status. Three studies found no statistical significance between vitamin D levels and fetal growth. Vitamin D status and ethnicity were correlated; vitamin D interacts with calcium levels in pregnant mothers to improve bone mineralization and fetal growth.
Conclusion and Implications for Translation: Further studies are needed to understand the relationship between maternal vitamin D, ethnicity, and fetal growth and the long-term effects of maternal vitamin D levels on neonatal, early childhood, and adolescent growth.

Copyright © 2021 Karmali et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
HIV Prevention in sub-Saharan Africa: Where Are Adolescents in the Continuum?
Authors: Armstrong-Mensah Elizabeth , Tetteh Ato Kwamena 
Published: December 2021

The human immunodeficiency virus (HIV) is the leading cause of death among adolescents in sub-Saharan Africa and the second leading cause of death among adolescents globally, yet this population is not expressly targeted in HIV prevention. Consequently, HIV prevalence among this population continues to rise. In 2014, McNairy and El-Sadr developed and proposed an HIV prevention continuum framework to ensure zero HIV infection among HIV uninfected people. While a step in the right direction, the continuum does not categorically focus on adolescents and thus, does not include mechanisms to offset the potential challenges this population experiences in HIV prevention. Intentionally involving adolescents in HIV prevention is crucial, as this population is considered integral to achieving the Sustainable Development Goal 3.3 target of eliminating HIV by 2030. This paper examines the challenges of adolescent participation in HIV prevention in sub-Saharan Africa using the McNairy and El-Sadar HIV prevention continuum framework as a backdrop.

Copyright © 2021 Armstrong-Mensah et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Hydrodynamic characteristics of lateral withdrawal with effects of the slope ratio
Authors: Zhao Wen-long , Zhang Jian , He Wei , Zhang Tian-xiang , Wang Shan , Shi Lin 
Published: December 2021

AbstractLateral withdrawal is widely performed in water transfer and water supply projects. Hydrodynamic characteristics of intake are crucial to safe and stable operation. In this study, a 3-D numerical volume of fluid model was established and validated through experimental tests. Hydrodynamic characteristics and secondary flow were investigated under scenarios with the vertical slope and different slope ratios. The helix-shaped recirculation and surface vortex are generated, and the secondary flow near the surface layer is more serious. Adding a slope ratio is beneficial to improve the flow patterns and recirculation, while the surface vortex width increases. Additionally, with the decrease in the slope ratio, recirculation width and the ratio of recirculation to the width of the layer decrease, and the minimum values are 9.19 cm and 22.97%, respectively. However, the lower the slope ratio is, the greater the recirculation inhibition effects, and the more serious the surface vortex. With the decrease in the slope ratio, the widest surface vortex width and the ratio of the widest surface vortex to the width of the layer increase from 6.1 to 12 cm and from 7.82 to 17.14%, respectively. This research represents an advance in lateral withdrawal and provides support for further designs.
The potential of Blue-Green infrastructure as a climate change adaptation strategy: a systematic literature review
Authors: Almaaitah Tamer , Appleby Madison , Rosenblat Howard , Drake Jennifer , Joksimovic Darko 
Published: December 2021

Abstract
Blue-Green Infrastructure (BGI) consists of natural and semi-natural systems implemented to mitigate climate change impacts in urban areas, including elevated air temperatures and flooding. This study is a state-of-the-art review that presents recent research on BGI by identifying and critically evaluating published studies that considered urban heat island mitigation and stormwater management as potential benefits. Thirty-two records were included in the review, with the majority of studies published after 2015. Findings indicate that BGI effectively controls urban runoff and mitigates urban heat, with the literature being slightly more focused on stormwater management than urban heat island mitigation. Among BGI, the studies on blue- and blue-green roofs focused on one benefit at a time (i.e. thermal or hydrologic performance) and did not consider promoting multiple benefits simultaneously. Two-thirds of the selected studies were performed on a large urban scale, with computer modelling and sensor monitoring being the predominant assessment methods. Compared with typical Green Infrastructure (GI), and from a design perspective, many crucial questions on BGI performance, particularly on smaller urban scales, remain unanswered. Future research will have to continue to explore the performance of BGI, considering the identified gaps.
Are we planning blue-green infrastructure opportunistically or strategically? Insights from Sydney, Australia
Authors: Kuller Martijn , Reid David J. , Prodanovic Veljko 
Published: December 2021

AbstractStrategic placement of water-sensitive urban design (WSUD) is essential in optimising its performance and maximising co-benefits. However, little is known about the current placement and interconnectedness between WSUD assets and the performance of current planning strategies. We evaluated the placement of existing WSUDs in a highly urbanised catchment in Sydney, Australia. We used a three-step process: (1) compiling a comprehensive spatial asset database, (2) performing spatial correlation analysis between asset locations and biophysical, urban form and socioeconomic variables and (3) using a novel approach to facilitate holistic understanding through analysing asset locations compared with the outcome of the spatial suitability analysis tool (SSANTO). WSUD coverage was generally low, with clustering in some municipalities. Placement was constrained by physical variables, such as slope, limited space and varying land uses. However, placement was not detectably influenced by most socioeconomic variables. SSANTO's suitability score at asset locations was only slightly higher than average, suggesting that the placement of existing WSUD was opportunistic, rather than strategically planned. Further development and implementation of tools able to account for spatial constraints will help guide future WSUD placement as a component of green urban stormwater management.
Isotopic and hydrogeochemical characterization of groundwater and surface water from a mine site in Tanzania
Authors: Musiba Musiba Masamba , Rwiza Mwemezi J. 
Published: December 2021

Abstract
This study used the hydrochemical properties of water to reveal the causes of water quality degradation. The results showed that most samples located downstream of the mine tailings dam were slightly acidic with pH as low as 4.6. Samples with high levels of Na+, Cl−, and could not be isotopically linked to the local geochemistry, but the anthropogenic activities and evaporation were probably responsible for the observed water chemistry. The Piper diagram indicated cations were dominated by Ca and Mg, while anions were dominated by bicarbonates and sulphates. Pb and Hg levels (mean 70.29 and 17.95 μg/L, respectively) were all higher than the World Health Organization (WHO) and Tanzanian drinking water guidelines. Mining activities probably contributed to the observed low pH values and elevated concentration of cyanides, heavy metals, and metalloids. Stable isotope results indicated a vulnerability of the water to recent contamination that could be attributed to anthropogenic activities. Moreover, isotopic studies indicated a flow pattern from the eastern to the western side of the mine study site. Lowland samples were more 3H-enriched than highland ones. The present study concludes that groundwater recharge from recent local precipitation may have an impact on the sources studied.