bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1
Authors: Weaver Tyler M. , Click Timothy H. , Khoang Thu H. , Todd Washington M. , Agarwal Pratul K. , Freudenthal Bret D. 
Published: December 2021

AbstractRev1 is a translesion DNA synthesis (TLS) polymerase involved in the bypass of adducted-guanine bases and abasic sites during DNA replication. During damage bypass, Rev1 utilizes a protein-template mechanism of DNA synthesis, where the templating DNA base is evicted from the Rev1 active site and replaced by an arginine side chain that preferentially binds incoming dCTP. Here, we utilize X-ray crystallography and molecular dynamics simulations to obtain structural insight into the dCTP specificity of Rev1. We show the Rev1 R324 protein-template forms sub-optimal hydrogen bonds with incoming dTTP, dGTP, and dATP that prevents Rev1 from adopting a catalytically competent conformation. Additionally, we show the Rev1 R324 protein-template forms optimal hydrogen bonds with incoming rCTP. However, the incoming rCTP adopts an altered sugar pucker, which prevents the formation of a catalytically competent Rev1 active site. This work provides novel insight into the mechanisms for nucleotide discrimination by the TLS polymerase Rev1.
The influence of e-customer satisfaction, e-trust and perceived value on consumer's repurchase intention in B2C e-commerce segment
Authors: Miao Miao , Jalees Tariq , Zaman Syed Imran , Khan Sherbaz , Hanif Noor-ul-Ain , Javed Muhammad Kashif 
Published: December 2021

PurposeThis research study investigates the factors that influence e-customer satisfaction, e-trust, perceived value and consumers repurchase intention in the context of the B2C e-commerce segment. It investigates the mediation effect of e-customer satisfaction, e-trust and perceived value on repurchase intention. It also examines the moderating role of prior online experience.Design/methodology/approachBased on the adapted questionnaire, pre-recruited enumerators collected the data from five leading business universities of Karachi. They distributed 425 questionnaires and received 415 questionnaires. The study has used Partial Least Square-Structure Equation Modeling (PLS-SEM) technique for data analysis.FindingsWe have tested 20 hypotheses, of which our results do not support five, including two direct, two mediating. Our results support all the direct hypotheses except the following two: (1) delivery service affects e-satisfaction (2) customer services quality effect on trust. We did not find support for the following two mediating hypotheses (1) e-satisfaction mediates delivery services and repurchase intention, (2) service quality mediates customers' service quality and repurchase intention. Our results do not support one moderating relationship. Prior online experience moderates e-perceived value and repurchase intention.Research limitations/implicationsThis research provides valuable information to the online retailers of B2C e-commerce, which can help them make strategies based on their consumers' behavior and encourage them to make repeat purchases from online retailing stores. It allows future researchers to replicate the model in cross-cultural studies in different product categories.Originality/valueWe have examined the moderating effect of prior online experience between (e-satisfaction, e-trust and perceived value) on the repurchase intention.
Creating sustainable value through food waste management: does retail customer value proposition matter?
Authors: Huang Iona Yuelu , Manning Louise , Wood Vicky , James Katy L. , Millington Anthony , Grigoriadis Vasilis , Ward Shane 
Published: December 2021

PurposeThis research aims to explore retail managers' views on how food waste (FW) management activities contribute to sustainable value creation and how the customer value proposition (CVP) for a given food retailer interacts with their approaches to FW management.Design/methodology/approachA three-stage exploratory qualitative approach to data collection and analysis was adopted, involving in-depth interviews with retail managers, documentary analysis of multiple years of relevant corporate reports and email validation by seven major UK grocery retailers. Thematic content analysis supplemented by word similarity cluster analysis, two-step cluster analysis and crisp-set qualitative comparative analysis was undertaken.FindingsFW management practices have been seen by retail managers to contribute to all forms of sustainable value creation, as waste reduction minimises environmental impact, saves costs and/or serves social needs, whilst economic value creation lies at the heart of retail FW management. However, retail operations are also framed by CVP and size of a retailer that enable or inhibit the adoption of certain FW management practices. Low-price retailers were more likely to adopt practices enabling them to save costs. Complicated cost-incurring solutions to FW were more likely to be adopted by retailers associated with larger size, high quality and a range of services.Originality/valueThis study is the first of its kind to empirically explore retail managers' perception of sustainable value creation through FW management activities and to provide empirical evidence of the linkages between retail CVP and sustainable value creation in the context of retail FW management.
Participatory design in refugee camps: Ethnographic case studies from Greece
Authors: Jaradat Suha , Beunders Narda 
Published: December 2021

PurposeArchitectural management and construction practices have not been widely explored in refugee camps which have been growing exponentially around the world. Previous research largely focused on the negativity surrounding living in refugee camps and mostly ignored the input of refugees. This study explores the possibilities of involving refugees in architectural design and construction decisions in the camps.Design/methodology/approachThis research adopts a qualitative interpretive research approach and employs exploratory ethnographic methods. Participatory design (PD) principles are applied to design and construct community place projects in two refugee camps in Greece.FindingsThe findings demonstrate that, despite the technical and institutional challenges of employing PD approaches in refugee camps, there are observed positive impacts on the wellbeing of refugees and impacts on the hosting communities.Practical implicationsThis paper contests the negativity surrounding refugee camps and has implications on research, practice and society as well as a positive impact on NGO organisations, policy-makers and other stakeholders involved in the governance of refugee camps.Originality/valueThis paper addresses a critical issue concerning how to include refugees in the design, implementation and maintenance of refugee camps to improve their well-being and fight the feeling of “otherness” for both refugees and host communities. This study extends research on refugee camps by collaborating with refugees to improve their lives within the camps. This research contributes to architectural management and construction studies by providing practical recommendations related to PD methods in new contexts.
Supporting justice-involved people with extreme complex needs in the Australian community: a third sector practice perspective
Authors: Hanley Natalia , Simpson Helen , Tauri Juan M. 
Published: December 2021

Purpose
This qualitative research aims to explore staff perspectives on working effectively with people with intellectual disability who are in contact with the criminal justice system.

Design/methodology/approach
Taking a case study approach, staff working for a third sector community organisation were interviewed about the components of effective work with their customers. The staff supported people engaged in the Community Justice Program.

Findings
Staff consistently described relationship building as the most important part of their work. There were three components to relationship building: the process of relationship building, the elements of a high-quality staff–customer relationship and the staff skills needed to develop a good relationship.

Originality/value
This paper makes two contributions to the literature. First, it focuses our attention on a third sector organisation supporting people in contact with the justice system as opposed to a formal criminal justice agency. Second, the paper seeks to understand the processes and skills staff deploy to build a high-quality relationship with criminal justice-involved people with intellectual disability.
Trauma and institutional risk in a secure developmental disorder service: does the SAVRY inflate risk in adolescents exposed to ACEs?
Authors: Webb Elanor Lucy , Morris Deborah , Hamer Abbey , Davies Jessica 
Published: December 2021

Purpose
Adverse childhood experiences (ACEs) are highly prevalent in people with developmental disorders who engage in offending behaviour. Many violence-based risk assessment tools include items pertaining to ACEs, and may inflate risk scores in trauma-exposed groups. This paper aims to explore the relationships between ACEs, risk assessment scores, incidents of risk and restrictive practices, in adolescents with developmental disorders in a forensic inpatient setting.

Design/methodology/approach
Secondary analysis was conducted on clinical data for 34 adolescents detained to a developmental disorder service. Data were extracted for Structured Assessment of Violence Risk in Youth (SAVRY) risk scores and risk behaviours and restrictive practices, as measures of observed risk.

Findings
Participants exposed to more ACEs had higher SAVRY risk scores (p < 0.001, two-tailed), with elevations specifically on the historical subscale (p < 0.001, two-tailed). Neither ACEs nor risk scores were associated with the frequency of risk behaviours. Nevertheless, participants exposed to four or more ACEs were secluded more frequently (p = 0.015, two-tailed), indicating a potential association between trauma and risk severity. Those with more complex developmental disorders experienced fewer ACEs (p = 0.02, two-tailed) and engaged in self-harm behaviours less frequently (p = 0.04, two-tailed).

Research limitations/implications
The inclusion of ACEs in risk assessment tools may lead to the inadvertent stigmatization of trauma-exposed individuals. Further investigation is necessary to offer clarity on the impact of early adversity on risk assessment accuracy and levels of institutional risk, and the role of developmental disorders in this relationship.

Originality/value
To the best of the authors’ knowledge, this study is the first to explore the relative associations between ACEs, risk assessment scores and observed institutional risk and does so in a highly marginalized population.
The effect of small business leaders' organisational mindfulness and social learning on opportunistic behaviour to survive the COVID-19 pandemic
Authors: Lusiantoro Luluk , Purwanto Bernardinus Maria , Rostiani Rokhima 
Published: December 2021

PurposeThis research aims to test the relationships between organisational mindfulness, social learning and opportunistic behaviour of small business leaders during the COVID-19 pandemic.Design/methodology/approachSemi-structured interviews were conducted with six small business leaders from various sectors to explore and better grasp the unprecedented phenomenon. An online survey on small business owners and managers in Indonesia was then employed as the main study, resulting in 291 valid responses for further analysis. The data were analysed using regression on SmartPLS 3.0 software.FindingsThis research finds that organisational mindfulness and social learning have positive and significant associations with the ability of small business leaders to discover and exploit opportunities. The path analysis suggests that organisational mindfulness plays a pivotal role as it also partially mediates the relationship between social learning and opportunistic behaviour.Originality/valueThis is the first paper to test the relationships between organisational mindfulness, social learning and opportunistic behaviour, particularly in the context of COVID-19 pandemic. This work also contributes by emphasising the critical linkages between internal and external capabilities triggered by small business leaders to survive the pandemic.
Barriers to institutionalization of an IFRS-based model: perceptions of Portuguese auditors
Authors: Soares Fontes Alexandra , Lima Rodrigues Lúcia , Marques Carla , Silva Ana Paula 
Published: December 2021

Purpose
In 2010, Portugal’s newly implemented Accounting Standardization System (SNC - Sistema de Normalização Contabilística) aligned Portuguese accounting standards for unlisted companies with International Financial Reporting Standards (IFRS). The purpose of this paper is to explore the influence of the local context and the role of auditors in the institutionalization of this IFRS-based model in Portugal.

Design/methodology/approach
Drawing from an institutional theory framework, the authors interviewed 16 Portuguese auditors in 2017 (seven years after formal implementation of the SNC) to determine their perceptions on whether barriers to the IFRS-based model persisted.

Findings
The authors reveal that the code-law institutional logic embedded in the Portuguese context is hindering full institutionalization of the new accounting model. Some persisting barriers to implementation reflected a decoupling between formal requirements and actual practices. Despite these barriers, there has been an encouraging institutionalization of SNC. The authors reveal a high level of commitment of auditors. They draw attention to the engagement of auditors in the institutional work that is intended to assist in SNC implementation, and their role as promoters of a power-knowledge discourse in propagating IFRS institutional logics at the national level, namely, through the justification and rationalization of the reported institutional contradictions.

Practical implications
The highlighting the authors provide of problems related to accounting change should assist international regulators, the Portuguese standard-setter and professional accounting associations to devise appropriate strategies to promote IFRS-based accounting systems implementation.

Originality/value
The authors contribute to the skimpy literature on micro institutional analysis and encourage further exploration of the dynamics between the micro and macro levels of analysis in institutional research.
Social entrepreneurship review: a gap in the Latin American context
Authors: Ibáñez María José 
Published: December 2021

Purpose
Social entrepreneurship (SE) has been a field of research that has interested researchers for over 30 years. However, there is no consensus on the concept of SE, and research in this field moves in several directions. The purpose of this study is to summarize the definitions of SE, propose a unified definition of SE and describe the state-of-the-art of SE in the Latin American context.

Design/methodology/approach
This study carries out a literature review on SE from 2010 to 2020 to explore the main topics in the SE field, searching, reviewing and selecting the most representative articles published.

Findings
The findings of this study suggest agreements and disagreements in the main topics of SE and reveal a significant gap in the SE research in the Latin American scenario.

Originality/value
This study contributes to the future growth of SE literature under a common umbrella that allows for more and better knowledge in this field and proposes a novel research agenda for the SE field in Latin America.
The extended late career phase – examining senior nursing professionals
Authors: Salminen Hanna , von Bonsdorff Monika E. , McPhee Deborah , Heilmann Pia 
Published: December 2021

PurposeBy relying on a sustainable career perspective and recent studies on senior employees’ late career phase, this study aims to examine senior (50+) nurses’ late career narratives in the context of extending retirement age. Given the current global nursing shortage, there is a pressing need to find ways on how to promote longer and sustainable careers in the health-care field. Yet, there is limited knowledge about the extended late career phase of senior nurses.Design/methodology/approachEmpirical data were derived from 22 interviews collected among senior (50+) nursing professionals working in a Finnish university hospital. The qualitative interview data were analysed using a narrative analysis method. As a result of the narrative analysis, four career narratives were constructed.FindingsThe findings demonstrated that senior nurses’ late career narratives differed in terms of late career aspirations, constraints, mobility and active agency of one’s own career. The identified career narratives indicate that the building blocks of sustainable late careers in the context of extending retirement age are diverse.Research limitations/implicationsThe qualitative interview data were restricted to senior nurses working in one university hospital. Interviews were conducted on site and some nurses were called away leaving some of the interviews shorter than expected.Practical implicationsTo support sustainable late careers requires that attention be based on the whole career ecosystem covering individual, organizational and societal aspects and how they are intertwined together.Originality/valueSo far, few studies have investigated the extended late career phase of senior employees in the context of a changing career landscape.
Processing and properties of PLA/Mg filaments for 3D printing of scaffolds for biomedical applications
Authors: Pascual-González Cristina , Thompson Cillian , de la Vega Jimena , Biurrun Churruca Nicolás , Fernández-Blázquez Juan P. , Lizarralde Iker , Herráez-Molinero Diego , González Carlos , LLorca Javier 
Published: December 2021

Purpose
This paper aims to develop a novel strategy to manufacture poly-lactic acid (PLA) filaments reinforced with Mg particles for fused filament fabrication of porous scaffolds for biomedical applications.

Design/methodology/approach
The mixture of PLA pellets and Mg particles was extruded twice, the second time using a precision extruder that produces a filament with zero porosity, constant diameter and homogeneous dispersion of Mg particles. The physico-chemical properties of the extruded filaments were carefully analysed to determine the influence of Mg particles on the depolymerisation of PLA during high temperature extrusion and the optimum melt flow index to ensure printability.

Findings
It was found that the addition of a polyethylene glycol (PEG) plasticizer was necessary to allow printing when the weight fraction of Mg was above 4%. It was possible to print porous face-centre cubic scaffolds with good geometrical accuracy and minimum porosity with composite filaments containing PEG.

Originality/value
The new strategy is easily scalable and seems to be very promising to manufacture biodegradable thermoplastic/metal composite filaments for 3D printing that can take advantage of the different properties of both components from the viewpoint of tissue engineering.
Emotional reactivity and difficulties in emotional regulation in drug users: a study in adolescents undergoing treatment in a therapeutic community
Authors: Serra Lídia , Silva Luís , Vilar Duarte 
Published: December 2021

Purpose
The purpose of this study is to investigate which emotions and difficulties in the emotional regulation of adolescents with illicit substance consumption.

Design/methodology/approach
In total, 41 adolescents undergoing treatment for the use of alcohol and drugs were recruited. The instruments used were the emotional rating scale and the difficulties in the regulation of emotions scale.

Findings
Emotional reactivity showed significant differences in the sadness dimension in relation to the number of cannabis cigarettes smoked daily and length of stay, and in the surprise dimension in relation to the number of cannabis cigarettes smoked daily. There was a significant correlation between happiness and age, surprise and number of siblings, sadness and school absenteeism and fear, school absenteeism and number of substances consumed. In regard to difficulties in emotional regulation, there were significant differences between the groups, in strategies regarding the gender of the participants and the number of substances consumed, in non-acceptance and impulses and in the number of substances consumed and in the awareness of the type and number of substances consumed. There was a significant correlation between strategies, non-acceptance, awareness and impulses and the number of substances consumed.

Originality/value
This study demonstrated that the emotional problems of adolescents admitted to a therapeutic community are predictors of illicit substance use.
Enhancing employees’ creativity through entrepreneurial leadership: can knowledge sharing and creative self-efficacy matter?
Authors: Islam Talat , Asad Momina 
Published: December 2021

Purpose
This study aims to examine knowledge sharing as an explanatory variable between entrepreneurial leadership and employee creativity. The authors further examined the moderating role of creative self-efficacy between knowledge sharing and employee creativity.

Design/methodology/approach
The authors collected data from 307 employees and their immediate supervisors working in IT-based organizations.

Findings
The authors noted that entrepreneurial leaders positively affect employees’ creativity and knowledge sharing positively explains this association. The authors further noted individuals high in creative self-efficacy strengthen the association between knowledge sharing and employee creativity.

Research limitations/implications
The authors used a cross-sectional design to collect data that may restrict causality. Still, the study suggests management learn, develop and implement entrepreneurial skills that foster knowledge sharing to enhance creativity. In addition, hiring individuals with creative self-efficacy would further encourage creativity.

Originality/value
Drawing upon social exchange theory, the authors are first to examine knowledge sharing as a mediating mechanism between entrepreneurial leadership and employee creativity. In addition, the authors examined creative self-efficacy as a conditional variable on the association between knowledge sharing and employee creativity.