bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Information Systems for Older Persons in Select Government Tertiary Hospitals and Health Centers in the Philippines: Cross-sectional Study
Authors: Garcia Angely P , De La Vega Shelley F , Mercado Susan P 
Published: July 2021

Background
The rapid aging of the world’s population requires systems that support health facilities’ provision of integrated care at multiple levels of the health care system. The use of health information systems (HISs) at the point of care has shown positive effects on clinical processes and patient health in several settings of care.

Objective
We sought to describe HISs for older persons (OPs) in select government tertiary hospitals and health centers in the Philippines. Specifically, we aimed to review the existing policies and guidelines related to HISs for OPs in the country, determine the proportion of select government hospitals and health centers with existing health information specific for OPs, and describe the challenges related to HISs in select health facilities.

Methods
We utilized the data derived from the findings of the Focused Interventions for Frail Older Adults Research and Development Project (FITforFrail), a cross-sectional and ethics committee–approved study. A facility-based listing of services and human resources specific to geriatric patients was conducted in purposively sampled 27 tertiary government hospitals identified as geriatric centers and 16 health centers across all regions in the Philippines. We also reviewed the existing policies and guidelines related to HISs for OPs in the country.

Results
Based on the existing guidelines, multiple agencies were involved in the provision of services for OPs, with several records containing health information of OPs. However, there is no existing HIS specific for OPs in the country. Only 14 (52%) of the 27 hospitals and 4 (25%) of the 16 health centers conduct comprehensive geriatric assessment (CGA). All tertiary hospitals and health centers are able to maintain medical records of their patients, and almost all (26/27, 96%) hospitals and all (16/16, 100%) health centers have data on top causes of morbidity and mortality. Meanwhile, the presence of specific disease registries varied per hospitals and health centers. Challenges to HISs include the inability to update databases due to inadequately trained personnel, use of an offline facility–based HIS, an unstable internet connection, and technical issues and nonuniform reporting of categories for age group classification.

Conclusions
Current HISs for OPs are characterized by fragmentation, multiple sources, and inaccessibility. Barriers to achieving appropriate HISs for OPs include the inability to update HISs in hospitals and health centers and a lack of standardization by age group and disease classification. Thus, we recommend a 1-person, 1-record electronic medical record system for OPs and the disaggregation and analysis across demographic and socioeconomic parameters to inform policies and programs that address the complex needs of OPs. CGA as a required routine procedure for all OPs and its integration with the existing HISs in the country are also recommended.
A Casual Video Game With Psychological Well-being Concepts for Young Adolescents: Protocol for an Acceptability and Feasibility Study
Authors: Pine Russell , Mbinta James , Te Morenga Lisa , Fleming Theresa 
Published: July 2021

Background
Many face-to-face and digital therapeutic supports are designed for adolescents experiencing high levels of psychological distress. However, promoting psychological well-being among adolescents is often neglected despite significant short-term and long-term benefits.

Objective
This research has 3 main objectives: (1) to assess the acceptability of Match Emoji, a casual video game with psychological well-being concepts among 13-15-year-old students in a New Zealand secondary school; (2) to identify the feasibility of the research process; and (3) to explore the preliminary well-being and therapeutic potential of Match Emoji.

Methods
Approximately 40 participants aged 13-15 years from a local secondary college in Wellington, New Zealand, will be invited to download and play Match Emoji 3-4 times a week for 5-15 minutes over a 2-week period. Participants will complete 4 assessments at baseline, postintervention, and 3 weeks later to assess psychological well-being and therapeutic changes. Statistical analysis will be used to synthesize data from interviews and triangulated with assessment changes and game analytics. This synthesis will help to assess the acceptability and feasibility of the Match Emoji.

Results
The key outputs from the project will include the acceptability, feasibility, and therapeutic potential of Match Emoji. It is anticipated that participants will have finished playing the recommended game play regimen by August 2021 with analysis of results completed by October 2021.

Conclusions
Data from the study are expected to inform future research on Match Emoji including a randomized controlled trial and further adjustments to the design and development of the game.

International Registered Report Identifier (IRRID)
PRR1-10.2196/31588
Longitudinal, Interdisciplinary Home Visits Versus Usual Care for Homebound People With Advanced Parkinson Disease: Protocol for a Controlled Trial
Authors: Fleisher Jori E , Hess Serena , Sennott Brianna J , Myrick Erica , Wallace Ellen Klostermann , Lee Jeanette , Sanghvi Maya , Woo Katheryn , Ouyang Bichun , Wilkinson Jayne R , Beck James , Johnson Tricia J , Hall Deborah A , Chodosh Joshua 
Published: July 2021

Background
The current understanding of advanced Parkinson disease (PD) and its treatment is largely based on data from outpatient visits. The most advanced and disabled individuals with PD are disconnected from both care and research. A previous pilot study among older, multimorbid patients with advanced PD demonstrated the feasibility of interdisciplinary home visits to reach the target population, improve care quality, and potentially avoid institutionalization.

Objective
The aim of this study protocol is to investigate whether interdisciplinary home visits can prevent a decline in quality of life of patients with PD and prevent worsening of caregiver strain. The protocol also explores whether program costs are offset by savings in health care utilization and institutionalization compared with usual care.

Methods
In this single-center, controlled trial, 65 patient-caregiver dyads affected by advanced PD (Hoehn and Yahr stages 3-5 and homebound) are recruited to receive quarterly interdisciplinary home visits over 1 year. The 1-year intervention is delivered by a nurse and a research coordinator, who travel to the home, and it is supported by a movement disorder specialist and social worker (both present by video). Each dyad is compared with age-, sex-, and Hoehn and Yahr stage–matched control dyads drawn from US participants in the longitudinal Parkinson’s Outcome Project registry. The primary outcome measure is the change in patient quality of life between baseline and 1 year. Secondary outcome measures include changes in Hoehn and Yahr stage, caregiver strain, self-reported fall frequency, emergency room visits, hospital admissions, and time to institutionalization or death. Intervention costs and changes in health care utilization will be analyzed in a budget impact analysis to explore the potential for model adaptation and dissemination.

Results
The protocol was funded in September 2017 and approved by the Rush Institutional Review Board in October 2017. Recruitment began in May 2018 and closed in November 2019 with 65 patient-caregiver dyads enrolled. All study visits have been completed, and analysis is underway.

Conclusions
To our knowledge, this is the first controlled trial to investigate the effects of interdisciplinary home visits among homebound individuals with advanced PD and their caregivers. This study also establishes a unique cohort of patients from whom we can study the natural course of advanced PD, its treatments, and unmet needs.

Trial Registration
ClinicalTrials.gov NCT03189459; http://clinicaltrials.gov/ct2/show/NCT03189459.

International Registered Report Identifier (IRRID)
PRR1-10.2196/31690
“Just Shave It Off”
Authors: Jankowski Glen , Sherwin Michael , Deighton-Smith Nova , Bell Beth T. 
Published: July 2021

Introduction Head hair comprises a critical part of the male appearance ideal, which itself is a crucial signifier of a man’s masculinity. However, difficulties in recruitment have meant that research has not yet fully explored how men construct the loss of head hair (baldness), perhaps because it is considered “feminine” to disclose body dissatisfaction experiences to a researcher or other people. Methods and Design Online forums provide an opportunity for the anonymous discussion of body dissatisfaction that may overcome this obstacle. The first 260 forums posts from the two most popular baldness forums were thematically analysed. Ethics Statement Institutional ethics approval was granted. Results and Discussion We identified three themes titled: (1) Baldness is an ugly and demasculinising condition, (2) Baldness is stigmatised by a superficial society and superficial women and (3) Resistance to baldness despair. Our findings show baldness distress, and stigma exist though so does resistance, which can be comforting to men experiencing baldness or any form of body dissatisfaction. Conclusion and Implications Online forums are a salient resource to enhance our understanding of men’s balding concerns and disclosure barriers. Independent, professional and effective baldness support that unpacks baldness masculinised and medicalised framing is recommended.
Hubungan kausalitas ekspor batubara dengan pertumbuhan ekonomi Provinsi Jambi
Authors: Wahyuni Iis Puji , Amir Amri , Nurjanah Rahma 
Published: July 2021

In this study aims to (1) know the development of economic growth and know the development of coal exports (2) find out the causality of coal exports with the economic growth of Jambi Province. The data used in this study are secondary data sourced from the Central Statistics Agency (BPS) of Jambi Province. To answer these objectives, this study uses a type of quantitative descriptive research with an analysis model for the first and second problems using simple regression analysis and granger causality test. The results of the study show that (1) the average development of economic growth in Jambi Province in 2004-2018 was 6.15 percent; (2) the average development of coal exports is 149.64 percent, and (3) partially coal exports do not have a causal relationship to the economic growth of Jambi Province
Keywords: Economic growth, Coal exports
Urdimbre de la imagen
Authors: Sequeda Garrido Yezid David 
Published: July 2021

Derrumbar el bronce y poner pesadas esculturas a morder el asfalto, mientras se cuestionan biografías de personajes conocidos, son parte de este debate contemporáneo sobre la historia, la memoria y las formas de trasmisión del pasado nacional. En esta coyuntura, la imagen y todo lo que a ella se asocia resulta protagónico para movimientos y acciones que logran cobertura global en un momento convulso. Es precisamente el análisis de la imagen lo que alienta al historiador Carlos A. Flórez López a emprender un cuidadoso análisis de la utilidad de la imagen y de la iconografía como parte de la historia, así como de sus formas de transmisión, estudio, enseñanza y abordaje. Guiado por los aportes y la teoría contenida en trabajos que se han ocupado previamente y a fondo del tema, Flórez emprende una interesante reflexión sobre la importancia de la imagen y lo que su estudio puede aportar al conocimiento y al quehacer de la historiografía.
Evaluating SARS-CoV-2 infection under tenofovir-based antiviral prophylaxis: a multi-scale modeling analysis upon experimental data
Authors: Salazar Pablo M De , Ramos Javier , Cruz Victor L , Polo Rosa , Amo Julia Del , Buckee Caroline O. , Martínez-Salazar Javier 
Published: July 2021

Tenofovir has shown promising evidence of improving COVID-19 clinical
outcomes in observational studies, still to be confirmed in clinical
trials. Disease severity might be reduced under prophylaxis with the
prodrug tenofovir disoproxil fumarate (TDF), while the protection seems
to decrease, or even to lack, when using the alternative prodrug
tenofovir alafenamide fumarate (TAF). Aiming to understand why
TDF-prophylaxis might reduce COVID-19 severity upon infection we
developed a multi-scale analysis framework combining in
vitro susceptibility data, molecular docking, and within-host dynamics
modeling, and using remdesivir–the only antiviral approved to date
against COVID-19– as a point of reference.First, our docking model
predicted that intracellularly active tenofovir diphosphate binds into
the SARS-CoV-2 RNA polymerase in the same site as the antiviral
remdesivir triphosphate, but presents lower binding energy, likely
reducing the overall inhibition of viral replication and making the
antiviral efficacy more susceptible to the drug intracellular
concentration. Second, using data from in
vitro viral cultures with plausible TDF therapeutic
concentrations, we estimated that the drug can inhibit SARS-COV-2
replication at an efficacy ranging between 54-99% conditional to the
viral cycle length. Third, assuming values approximating this range of
inhibition for in vivo viral replication during human SARS-COV-2
infection, we found that prophylaxis with TDF with high penetration into
viral target cells is capable of delaying viral replication, mitigating
direct cell damage and allowing time for the host to mount the adaptive
immunity. Last, we found that the potential antiviral effect can be
substantially reduced when TDF is given after infection begins. Our work
provides a potential mechanistic explanation of the observed clinical
effect of TDF against SARS-CoV-2 infection. The proposed inference
framework can help to optimize the evaluation of antiviral therapies for
COVID-19, in particular those targeting the RNA dependent RNA
polymerase.
Loving GOD, Loving Others: The Evil of Hatred by Accidental Differences in Humankind
Authors: PhD Michael A. Milton, 
Published: July 2021

The rise of ideologies in the West that promote prejudicial
treatment of others based on accidental (humanly uncontrollable)
features (distinguishing ethnic physical traits, geographic origin,
physical or mental capacities, or native cultures, viz., Western
Civilization, that in all of its vicissitudes, has produced distinctive
behavioral, socio-religious, and intellectual norms) is an illogical,
cruel, and nationally self-destructive worldview that must be exposed
and rejected. The premise of “races” of human beings (Caucasian race,
negroid race, mongoloid race, etc.) , rather than the “race of
Mankind,” male and female, all originating from a common set of
ancestors, created by God, with “in-species” genetic variety (e.g.,
melanin production creating darker or lighter skin color) is not only
unsupported by the teachings of the Old and New Testaments, but singled
out as sins against God. The author examines a recent case of a medical
doctor dreaming of murdering white people. The statement is considered
from both scientific and spiritual viewpoints. The author cites personal
experience in the United States military, as well as peer-reviewed
articles, to establish the hypothesis that the rise of violent tribalism
(“Balkanization”) produces Socialistic authoritarianism, which
forcibly reunites divided “tribes” under the flag of autocratic rule.
This opinion-editorial article concludes by asserting that the Gospel of
Jesus Christ is the powerful antidote that liberates people from this
pestilent consequences of original sin to discover authentic fraternity
in our common Imago Dei (the image of God in
Man), and transformative freedom from the effects of the Fall,
i.e., to embrace and be embraced by a divine love that transcends our
sin. Only in knowing such love can we be free from the hatred that
divides, the bitterness that excludes, and the pain and sorrow that
inevitably follows.
Pengaruh Kepuasan Kerja dan Motivasi Terhadap Kinerja Pegawai Balai Pelestarian Situs Manusia Purba Sangiran
Authors: Purnamarini Tri Ratna 
Published: July 2021

Penelitian ini dilaksanakan dengan maksud untuk menguji pengaruh kepuasan kerja terhadap kinerja pegawai, menguji pengaruh motivasi terhadap kinerja pegawai serta menguji pengaruh kepuasan kerja dan motivasi terhadap kinerja pegawai Balai Pelestarian Situs Manusia Purba Sangiran. Jumlah sampel dalam penelitian ini sebanyak 30 responden. Data dianalisis mempergunakan analisis regresi linier berganda dengan bantuan program SPSS. Hasil penelitan menunjukkan bahwa secara sendiri variabel kepuasan kerja dinyatakan ada pengaruh positif dan signifikan terhadap kinerja pegawai. Variabel motivasi ada pengaruh positif tetapi tidak signifikan terhadap kinerja pegawai. Sedangkan secara simultan kepuasan kerja dan motivasi mempunyai pengaruh yang positif dan signifikan terhadap kinerja pegawai Balai Pelestarian Situs Manusia Purba Sangiran. Kata kunci ; Kepuasan Kerja, Motivasi, Kinerja Pegawai
A comparative analysis of two unrelated outbreaks in Latvia and Australia of acquired idiopathic megaesophagus in dogs fed two brands of commercial dry dog foods: 398 cases (2014–2018)
Authors: Hurley Karyl J. , Mansfield Caroline , VanHoutan Ilze Matīse , Lacorcia Lauren , Allenspach Karin , Hebbard Geoffrey , Marks Stanley L. , Poppenga Robert , Kaufman James H. , Weimer Bart C. , Woolard Kevin D. , Bielitzki Joe , Lulham Derek , Naar Jerome 
Published: July 2021

Abstract

CASE DESCRIPTION
In Latvia in 2014, acquired idiopathic megaesophagus (AIME) was observed in increased numbers of dogs that consumed varieties of 1 brand of dog food. Within 2 years, 253 dogs were affected. In Australia in November 2017, 6 working dogs that consumed 1 diet of another brand of dog food developed AIME. In total, 145 Australian dogs were affected.

CLINICAL FINDINGS
AIME was diagnosed predominantly in large-breed male dogs (> 25 kg [55 lb]). Regurgitation, weight loss, and occasionally signs consistent with aspiration pneumonia (coughing, dyspnea, or fever) were noted. Most Latvian dogs had mild to severe peripheral polyneuropathies as evidenced by laryngeal paralysis, dysphonia, weakness, and histopathologic findings consistent with distal axonopathy. In Australian dogs, peripheral polyneuropathies were not identified, and histopathologic findings suggested that the innervation of the esophagus and pharynx was disrupted locally, although limited samples were available.

TREATMENT AND OUTCOME
Investigations in both countries included clinical, epidemiological, neuropathologic, and case-control studies. Strong associations between the dog foods and the presence of AIME were confirmed; however, toxicological analyses did not identify a root cause. In Latvia, the implicated dietary ingredients and formulations were unknown, whereas in Australia, extensive investigations were conducted into the food, its ingredients, the supply chain, and the manufacturing facilities, but a cause was not identified.

CLINICAL RELEVANCE
A panel of international multidisciplinary experts concluded that the cause of AIME in both outbreaks was likely multifactorial, with the possibility of individualized sensitivities. Without a sentinel group, the outbreak in Australia may not have been recognized for months to years, as happened in Latvia. A better surveillance system for early identification of pet illnesses, including those associated with pet foods, is needed. (J Am Vet Med Assoc 2021;259:172–183)
Use of stereotactic body radiation therapy for treatment of a pancreatic tumor in a cat
Authors: Gaitan-Cobo Alba L. , Griffin Lynn R. , Kruckman-Gatesy Carolynne R. 
Published: July 2021

Abstract

CASE DESCRIPTION
A 16-year old castrated male domestic shorthair cat was evaluated at a veterinary teaching hospital because of polyuria, polydipsia, and weight loss of 2 months’ duration.

CLINICAL FINDINGS
Hematologic and biochemical examination results were within respective reference ranges except for moderately high pancreas-specific lipase concentration. Ultrasonographic and cytologic evaluation revealed a hepatic mass with findings consistent with mild cholestasis and inflammation and a pancreatic mass that was initially identified as a neuroendocrine tumor.

TREATMENT AND OUTCOME
The cat underwent additional CT assessment and stereotactic body radiation therapy (SBRT; 3 fractions of 8 Gy, administered every other day) for treatment of the pancreatic tumor. Follow-up ultrasonographic and CT examinations indicated a partial response to SBRT, with a maximum CT-measured size reduction from 3.6 × 4.8 × 4.0 cm at the time of treatment planning to 2.0 × 2.0 × 1.9 cm 8 months later. Increased pancreatic tumor size and signs of carcinomatosis were detected 15 months after SBRT treatment; the initial cytologic diagnosis was changed to exocrine pancreatic carcinoma on reevaluation of the slides by another veterinary pathologist. Carboplatin treatment was elected, and signs of carcinomatosis resolved. The cat was euthanized without further testing because of weakness 589 days after SBRT was started.

CLINICAL RELEVANCE
To the authors’ knowledge, this is the first report of SBRT for suspected exocrine pancreatic carcinoma in a cat. Further investigation is needed to determine optimal fractionation schedules for SBRT of pancreatic tumors and utility of SBRT of exocrine pancreatic carcinoma in cats. (J Am Vet Med Assoc 2021;259:184–189)
Effect of negative energy balance on plasma metabolites, minerals, hormones, cytokines and ovarian follicular growth rate in Holstein dairy cows
Authors: Song Yuxi , Wang Zhijie , Zhao Chang , Bai Yunlong , Xia Cheng , Xu Chuang 
Published: July 2021

Abstract

Introduction
The aim of this study was to evaluate the effect of negative energy balance (NEB) on the final growth of the dominant ovarian follicle in Holstein cows.

Material and Methods
Cows at 14 to 21 d postpartum from an intensive dairy farm were randomly selected and allocated into a positive energy balance group (PEB, with β-hydroxybutyric acid (BHBA) level < 1.2 mmol/L, n = 15) and an NEB group (BHBA > 1.2 mmol/L, n = 15). Plasma samples were collected at 21, 50 and 55 d postpartum to assess the concentrations of energy metabolites, minerals, hormones and cytokines. Ovaries were examined by transrectal ultrasound on days 50 and 55 (120 hours later) to evaluate the diameter of the largest follicle.

Results
Compared with PEB cows, there were a more severe body condition loss and a lower milk yield in NEB cows (P < 0.05) and these had greater concentrations of plasma BHBA, non-esterified fatty acids, triglycerides, urea nitrogen, growth hormone, interleukin 6, and fibroblast growth factor 21 and lesser concentrations of plasma glucose, total cholesterol, insulin, insulin-like growth factor 1, insulin-like growth factor binding protein 3, leptin, brain-derived neurotrophic factor and angiopoietin-like protein 8 on d 21 (P < 0.05), while plasma minerals were not affected by energy status (P > 0.05). These changes persisted until the end of the study period (50–55 days postpartum) resulting in a lower follicular growth rate for cows in the NEB than the PEB group.

Conclusion
These observations indicate that follicular growth rate is associated with measurable changes in energy metabolite, hormone and cytokine concentrations caused by early postpartum NEB.