bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole Tumor Capsule Is Prognostic of Very Good Outcome in the Classical Variant of Papillary Thyroid Cancer
Authors: Giani Carlotta , Torregrossa Liborio , Ramone Teresa , Romei Cristina , Matrone Antonio , Molinaro Eleonora , Agate Laura , Materazzi Gabriele , Piaggi Paolo , Ugolini Clara , Basolo Fulvio , Ciampi Raffaele , Elisei Rossella 
Published: June 2021

Abstract

Context
Tumor capsule integrity is becoming a relevant issue to predict the biological behavior of human tumors, including thyroid cancer.

Objective
This work aims to verify whether a whole tumor capsule in the classical variant of papillary thyroid carcinoma (CVPTC) could have as a predictive role of a good outcome as for follicular variant (FVPTC).

Methods
FVPTC (n = 600) and CVPTC (n = 554) cases were analyzed. We distinguished between encapsulated-FVPTC (E-FVPTC) and encapsulated-CVPTC (E-CVPTC) and, thereafter, invasive (Ei-FVPTC and Ei-CVPTC) and noninvasive (En-FVPTC and En-CVPTC) tumors, according to the invasion or integrity of the tumor capsule, respectively. Cases without a tumor capsule were indicated as invasive-FVPTC (I-FVPTC) and invasive-CVPTC (I-CVPTC). The subgroup of each variant was evaluated for BRAF mutations.

Results
E-FVPTC was more frequent than E-CVPTC (P &lt; .001). No differences were found between En-FVPTC and En-CVPTC or between Ei-FVPTC and Ei-CVPTC. After 18 years of follow-up, a greater number of not-cured cases were observed in Ei-CVPTC with respect to Ei-FVPTC, but not in En-CVPTC to En-FVPTC. Multivariate clustering analysis showed that En-FVPTC, En-CVPTC, and Ei-FVPTC have similar features but different from I-FVPTC and I-CVPTC and, to a lesser extent, from Ei-CVPTC. A total of 177 of 614 (28.8%) cases were BRAFV600E mutated, and 10 of 614 (1.6%) carried BRAF-rare alterations. A significantly higher rate of En-CVPTC (22/49, 44.9%) than En-FVPTC (15/195, 7.7%) (P &lt; .0001) were BRAFV600E mutated.

Conclusion
En-CVPTC is less prevalent than En-FVPTC. However, it has good clinical/ pathological behavior comparable to En-FVPTC. This finding confirms the good prognostic role of a whole tumor capsule in CVPTC as well. New nomenclature for En-CVPTC, similar to that introduced for En-FVPTC (ie, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; NIFTP) could be envisaged.
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Authors: Mauvais-Jarvis Franck 
Published: June 2021

Abstract
Coronavirus disease 2019 (COVID-19) is characterized by a gender disparity in severity, with men exhibiting higher hospitalization and mortality rates than women. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, infects cells following recognition and attachment of the viral spike glycoprotein to the angiotensin-converting enzyme 2 transmembrane protein, followed by spike protein cleavage and activation by cell surface transmembrane protease serine 2 (TMPRSS2). In prostate cancer cells, androgen acting on the androgen receptor increases TMPRSS2 expression, which has led to the hypothesis that androgen-dependent expression of TMPRSS2 in the lung may increase men’s susceptibility to severe COVID-19 and that, accordingly, suppressing androgen production or action may mitigate COVID-19 severity by reducing SARS-CoV-2 amplification. Several ongoing clinical trials are testing the ability of androgen deprivation therapies or anti-androgens to mitigate COVID-19.
This perspective discusses clinical and molecular advances on the rapidly evolving field of androgen receptor (AR) action on cell surface transmembrane protease serine 2 (TMPRSS2) expression and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and the potential effect of anti-androgens on coronavirus disease 2019 (COVID-19) severity in male patients. It discusses limitations of current studies and offers insight for future directions.
Calcium-Sensing Receptors Control CYP27B1-Luciferase Expression: Transcriptional and Posttranscriptional Mechanisms
Authors: Huang Alice , Binmahfouz Lenah , Hancock Dale P , Anderson Paul H , Ward Donald T , Conigrave Arthur D 
Published: June 2021

Abstract
25-hydroxyvitamin D 1α-hydroxylase (encoded by CYP27B1), which catalyzes the synthesis of 1,25-dihydroxyvitamin D3, is subject to negative or positive modulation by extracellular Ca2+ (Ca2+o) depending on the tissue. However, the Ca2+ sensors and underlying mechanisms are unidentified. We tested whether calcium-sensing receptors (CaSRs) mediate Ca2+o-dependent control of 1α-hydroxylase using HEK-293 cells stably expressing the CaSR (HEK-CaSR cells). In HEK-CaSR cells, but not control HEK-293 cells, cotransfected with reporter genes for CYP27B1-Photinus pyralis (firefly) luciferase and control Renilla luciferase, an increase in Ca2+o from 0.5mM to 3.0mM induced a 2- to 3-fold increase in firefly luciferase activity as well as mRNA and protein levels. Surprisingly, firefly luciferase was specifically suppressed at Ca2+o ≥ 5.0mM, demonstrating biphasic Ca2+o control. Both phases were mediated by CaSRs as revealed by positive and negative modulators. However, Ca2+o induced simple monotonic increases in firefly luciferase and endogenous CYP27B1 mRNA levels, indicating that the inhibitory effect of high Ca2+o was posttranscriptional. Studies with inhibitors and the CaSR C-terminal mutant T888A identified roles for protein kinase C (PKC), phosphorylation of T888, and extracellular regulated protein kinase (ERK)1/2 in high Ca2+o-dependent suppression of firefly luciferase. Blockade of both PKC and ERK1/2 abolished Ca2+o-stimulated firefly luciferase, demonstrating that either PKC or ERK1/2 is sufficient to stimulate the CYP27B1 promoter. A key CCAAT box (−74 bp to −68 bp), which is regulated downstream of PKC and ERK1/2, was required for both basal transcription and Ca2+o-mediated transcriptional upregulation. The CaSR mediates Ca2+o-dependent transcriptional upregulation of 1α-hydroxylase and an additional CaSR-mediated mechanism is identified by which Ca2+o can promote luciferase and possibly 1α-hydroxylase breakdown.
Very Low Vitamin D in a Patient With a Novel Pathogenic Variant in the GC Gene That Encodes Vitamin D-Binding Protein
Authors: Banerjee Ronadip R , Spence Tara , Frank Stuart J , Pandian Raj , Hoofnagle Andrew N , Argiropoulos Bob , Marcadier Julien L 
Published: June 2021

Abstract
Circulating plasma vitamin D metabolites are highly bound to vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin. DBP, encoded by the GC gene, is a member of the albumin family of globular serum transport proteins. We previously described a homozygous GC gene deletion in a patient with apparent severe vitamin D deficiency, fragility fractures, and ankylosing spondylitis. Here, we report an unrelated patient free of fractures or rheumatologic disease, but with very low 25-hydroxyvitamin D and 1,25-hydroxyvitamin D, as well as undetectable DBP measured by liquid chromatography–tandem mass spectrometry. A whole gene deletion was excluded by microarray, and Sanger sequencing of GC revealed a homozygous pathogenic variant affecting a canonical splice site (c0.702-1G &gt; A). These findings indicate that loss of function variants in GC that eliminate DBP, and severely reduced total circulating vitamin D levels, do not necessarily result in significant metabolic bone disease. Together with our previous report, these cases support the free-hormone hypothesis, and suggest free vitamin D metabolites may serve as preferable indicators of bone and mineral metabolism, particularly when clinical suspicion of DBP deficiency is high.
Medieval Scottish Historians and the Contest for Britain
Authors: Davies Daniel 
Published: June 2021

AbstractScholars often claim that medieval writers use Britain and England interchangeably, but Britain was a contested term throughout the period. One persistent issue was how Scotland fit within Anglocentric visions of the island it shared with England and Wales. This article traces imperialist geography in English historiography via the descriptio Britanniae (description of Britain), a trope found across the Middle Ages, and the fourteenth-century Gough Map, the first sheet-map of Britain. Scottish historians rebut the claims of their Anglocentric counterparts and demonstrate their incomplete knowledge, which they zealously supplement by inventorying Scotland’s natural abundance. In particular, the article concentrates on the remarkable celebration of Scotland’s marine life in Walter Bower’s Scotichronicon (ca. 1447). Attending to the long history of these debates both reveals and counteracts the Anglocentrism of insular literary history.
Histories of Fiction
Authors: Paige Nicholas 
Published: June 2021

AbstractOne shared assumption of many recent efforts to delineate a history of fiction (or fictionality, typically understood as a mode of nonliteral reference) is that that term names a conceptual operation, be it intrinsic or culturally learned. This article argues that fiction is merely a particular type of classification, akin but not identical to the classifications performed by terms such as mimesis or verisimilitude. Thus it is nonsensical to claim that fiction qua concept does or does not exist at any given moment: fiction is foremost a way of grouping various literary practices, and it is those practices that emerge over time. The article then recasts the interest in the early novel’s fictionality shown by Catherine Gallagher and others as a problem of practices rather than of concepts. It tracks trends in subject matter and assertions of literal truth through a quantitative diachronic analysis of 230 years of French novels. While these trends cannot by their very nature show the birth of the concept of fiction—which was never born in the first place—they are the type of evidence that should be central to any future history of fiction.
РАЗРАБОТКА ПРОГРАММЫ ВНЕУРОЧНОЙ ДЕЯТЕЛЬНОСТИ ПО ЭТНОКУЛЬТУРНОМУ ОБРАЗОВАНИЮ МЛАДШИХ ШКОЛЬНИКОВ CРЕДСТВАМИ ТРАДИЦИОННЫХ ЯПОНСКИХ ИСКУССТВ
Authors: Mitina Galina V. , Shalamova Ol’ga O. , Zor’kina Anna S. 
Published: June 2021

Цель. Одной из приоритетных задач начального общего образования на современном этапе определено духовно-нравственное развитие младших школьников. В младшем школьном возрасте закладываются основы космополитического мировоззрения, воспитания поликультурной личности, способной к межкультурному взаимодействию. Предметом анализа в данной статье выступает поиск путей решения данной задачи. В качестве цели авторы обозначают определение методов и средств этнокультурного образования младших школьников.
Метод или методология проведения работы. Основу исследования составили методы изучения нормативных документов, анализа и обобщения психолого-педагогической литературы, изучения культурологической и этнологической литературы, моделирования образовательного процесса.
Результаты. Результаты работы заключаются в том, что авторы раскрывают особенности младшего школьного возраста, создающие основу для этнокультурного образования и воспитания поликультурной личности: восприимчивость младших школьников к эмоционально-ценностному, духовно-нравственному развитию, гражданскому воспитанию. Одним из путей формирования основ космополитического мировоззрения, воспитания поликультурной личности является погружение школьников в культуру конкретного народа. Освоение традиций, обычаев, национальных искусств возможно проводить в рамках реализации программы внеурочной деятельности «Традиционные искусства народов мира».
Область применения результатов. Результаты исследования могут быть применены при организации внеурочной деятельности в системе начального общего образования, подготовке педагогов для указанного уровня образования.
ДИДАКТИЧЕСКИЕ ВОЗМОЖНОСТИ ВИРТУАЛЬНОЙ ДОСКИ MIRO И ОБРАЗОВАТЕЛЬНОГО РЕСУРСА WORDWALL ДЛЯ ОРГАНИЗАЦИИ РАБОТЫ СТУДЕНТОВ В ПРОЦЕССЕ ИЗУЧЕНИЯ ИНОСТРАННОГО ЯЗЫКА В ВУЗЕ
Authors: Astapenko Elena V. , Bedareva Alisa V. 
Published: June 2021

Введение. В настоящее время традиционные методики обучения смещаются в сторону современных информационных и коммуникационных технологий. Данный тезис встречается во многих нормативных образовательных документах, в том числе и во «Всемирной декларации о высшем образовании для XXI века: подходы и практические примеры», где подчеркивается необходимость «создания новых форм учебной среды, начиная от средств дистанционного образования и вплоть до полноценных «виртуальных» высших учебных заведений и систем, способных сокращать расстояния и разрабатывать высококачественные системы образования на благо социально-экономического развития и демократизации, а также другим наиболее актуальным приоритетам общества» [3].
Цель: представление локального опыта использования виртуальной доски Miro, а также образовательного ресурса Wordwall в качестве мультимедийного средства обучения в режиме синхронного и асинхронного обучения для организации групповой и индивидуальной работы в образовательном процесса Сибирского государственного университета науки и технологий имени М.Ф. Решетнева в условиях дистанционного обучения.
Методы и методология проведения работы. Основными методами исследования являются прогнозирование, проектирование, мониторинг результатов обучения, анкетный опрос. Исследование проводилось среди обучающихся 1–3 курса очной формы бакалавриата (38.03.01 Экономика, 38.03.02 Менеджмент, 42.03.01 Реклама и связи с общественностью) СибГУ имени М.Ф. Решетнева на протяжении осеннего семестра 2020 г.; в экспериментальном обучении приняли участие 124 человека.
Результаты. Результаты работы заключаются в определении дидактических возможностей использования виртуальной доски Miro и образовательного ресурса Wordwall как одного из средств организации групповой работы в процессе дистанционного обучения на занятиях иностранному языку.
Область применения результатов. Результаты исследования могут быть использованы в реализации процесса формирования языковой компетенции, в том числе в развитии «надпрофессиональных навыков» выпускников вузов на уровне бакалавриата.
АНАЛИЗ ГЛУБИННЫХ СЕМАНТИЧЕСКИХ СТРУКТУР КАК СПОСОБ ОПЕРАЦИОНАЛИЗАЦИИ ПРОЦЕССУАЛЬНОЙ МОДЕЛИ СТРУКТУРЫ ОБРАЗА МИРА
Authors: Skleynis Viktor A. 
Published: June 2021

Цель. Статья посвящена проблеме операционализации процессуальной модели структуры образа мира. Предметом анализа выступают модели систем значений. Автор ставит целью сопоставить процессуальную модель структуры образа мира с моделями систем значений, описывающих жизненный сценарий личности, а также архетипические структуры.
Метод или методология проведения работы. В качестве метода исследования нами был использован сопоставительный анализ компонентов процессуальной модели структуры образа мира с одной стороны и многоуровневых семантических структур с другой.
Результаты. Результаты работы заключаются в том, что автор рассматривает процессы развёртывания сценарных и архетипических структур как частный случай динамики процессуальной модели. С позиции уровня функционирования процесс из развёртывания может быть рассмотрен как влияние мотивационной подсистемы на целевую и функциональную, в то время как с позиции уровня обобщения – как процесс смыслообразования, характеризующийся переходом от синкретической и комплексной подсистем к понятийной. Данный процесс может осуществляться в нескольких направлениях функционирования: уровню внутренней деятельности соответствуют процессы внутриличностной динамики смысловых структур; уровню коммуникативной деятельности – процессы межличностного взаимодействия, а также взаимодействие субъекта с культурой как полем коллективных смыслов. Уровню практической деятельности можно поставить в соответствие поведенческие акты, обусловленные влиянием архетипических моделей и сценарных паттернов.
Область применения результатов. Решение задачи сопоставления моделей систем значений позволяют достичь эффекта синергии, с одной стороны позволяя дополнить представления о глубинных структурах образа мира, а с другой – использовать инструментарий психологии субъективной семантики и психосемантики для анализа процессов реализации жизненного сценария личности и архетипа. Полученные данные могут быть использованы для моделирования процессов реализации глубинных структур средствами психологии субъективной семантики при конструировании сообщения.
Examining the Impact of Professional Development on the Self-Determined Learning Model of Instruction for General and Special Educators
Authors: Bojanek Erin K. , Raley Sheida K. , Shogren Karrie A. , Lane Kathleen Lynne 
Published: June 2021

Abstract
There is limited research examining professional development for general and special education teachers implementing self-determination interventions. This study presents outcomes of a 2-day professional development training for the Self-Determined Learning Model of Instruction (SDLMI) for general and special educators guided by key elements of professional development. Results suggested teachers had positive perceptions of the training and showed improvements in knowledge and skills related to self-determination, but reported no change in perceived usefulness for students. Findings suggested teachers already perceived self-determination to be important and relevant to their students and that this professional development training was successful in improving teachers' knowledge and skills. Further research is needed to examine how this training impacts teacher implementation of the SDLMI and student outcomes.
Teacher-Implemented AAC Intervention to Support Peer Interaction in an Inclusive Preschool Classroom: A Pilot Study
Authors: Therrien Michelle C. S. 
Published: June 2021

Abstract
Children with complex communication needs confront many barriers to peer interaction and, without intervention, are at risk for social isolation, even in inclusive classrooms. The aims of this pilot study were to determine the feasibility of training a preschool teacher to implement a peer interaction intervention and to measure the impact on the participating children. The teacher in this study was taught to program an augmentative and alternative communication (AAC) app and to implement a peer interaction intervention. The teacher's positive perception of the training and intervention, along with the social improvements seen in this pilot study are promising. More research is needed to increase confidence in the effectiveness of this training to support teacher-implemented intervention and peer interaction in inclusive classrooms.
Comparison of the favorable gain values of genetic improvement among Indonesian grade cow breeds selected for agrotechnopark intensification
Authors: Paputungan U. , Hendrik M. J. , Siswosubroto S. E. 
Published: June 2021

This research was aimed to compare the small and big truncation point proportions intended to evaluate gain values of genetic improvement for Indonesian Local cow breed groups selected for Agrotechnopark (integrated bio-cycle farming system) intensification. Animal live weights were collected from 674 Indonesian grade breed cows kept by local household farmers in North Sulawesi province. Data of cows were corrected by adjusting to six years old ages. All cows were divided into three breed groups with different genetic compositions of Bali breed cow generation (BG) of 207 cows, Ongole grade cow generation (OG) of 189 cows, and Local grade cow generation (LG) of 178 cows. The genetic improvements of BG, OG and LG were analyzed involving selection intensity (i), accuracy of selection (r), and standard deviation (SD) of breed group traits under selection. Results of this study showed that the critical components was genetic development of local grade breeds by choosing small proportion of 10% truncation point for Agrotechnopark intensification of selected elite cows groups among BG, OG and LG populations with the positive live weight gains of 58.6 kg, 23.15 kg, and 28.62 kg per generation, respectively compared with larger percentages of 20% and 30% proportions of truncation points.
Association of Liver X Receptor Alpha (LXRα) gene related to characteristic of carcass, meat quality and fatty acid composition in ducks
Authors: Gunawan A. , Azmi N. , Anggraeni A. 
Published: June 2021

Liver X Receptor Alpha (LXRα) is a nuclear receptor that play a crucial role in regulating of gene involvedin lipid metabolism. The aim of this research was to identify polymorphisms and association of LXRα gene with charateristic of carcass, meat quality and fatty acid composition in ducks using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). A total sample of 98 Cihateup ducks consisted of 57 females and 41 males with age 12 weeks were used in this study. Product size is 661 bp amplicons. The genotype genes frequencies in CC, GC and GG were 0.21, 0.55 and 0.23 respectively. The chi-square test revealed that LXRα gene (g.3575 C>G) in exon 2 was in Hardy-Weinberg equilibrium. A SNP of LXRα gene in region g.3575 C>G was significantly associated (P<0.05) with duck meat quality and fatty acid content. Several parameters have significant affect (P <0. 05) on meat quality in the breast meat weight, carcass percentage and head percentage, while associated fatty acids were saturated fatty acids (SFA) such as palimitic acid (C16:0); γ-and unsaturated fatty acids (UFA) such as linolenic acid (C18:3n3); cis 11 eicosenoic acid (C20:1) and 11.14 cis-eicosedenoic acid (C20:2). In could be concluded that LXRα gene might be useful as genetic markers to select and produce meat with desirable unsaturated fatty acids.
Appropriate growth models to describe early growth of Kejobong goat based on Growth Hormone (GH) gene sequence analysis
Authors: Sutopo S. , Lestari D. A. , Oikawa T. , Konno T. , Purbowati E. , Setiaji A. , Kurnianto E. 
Published: June 2021

The objectives of this study were to reveal appropriate growth models describing early growth of Kejobong goat based on Growth Hormone (GH) gene sequence analysis. A total of 35 DNA samples and 1.960 records of quantitative traits of Kejobong goat were collected. The exon 3 of GH gene was amplified and was sequenced to determine the SNP. Body weight and body measurements of the goats were taken at 0-14 weeks of age. Four non-linear growth models were applied for analysis of growth to compare growth performance of different genotypes by Non-Linear Mixed Model. A non-synonymous mutation (g1170AG) genotyped into GG, AG and AA was significantly associated with growth traits. Animals with heterozygous genotype AG showed higher growth traits than animals with homozygous genotype AA. Nonetheless, animals with homozygous genotype GG had the same growth traits with those animals with heterozygous genotype AG and homozygous genotype AA. The most fitted model for describing body weight was Von Bertalanffy model, while for describing wither height and hip height was Brody model. SNP at exon 3 of the GH gene can be used as genetic marker for improvement of growth traits of Kejobong goats.