bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methanol at the Edge of the Galaxy: New Observations to Constrain the Galactic Habitable Zone
Authors: Bernal J. J. , Sephus C. D. , Ziurys L. M. 
Published: November 2021

Abstract
The Galactic Habitable Zone (GHZ) is a region believed hospitable for life. To further constrain the GHZ, observations have been conducted of the J = 2 → 1 transitions of methanol (CH3OH) at 97 GHz, toward 20 molecular clouds located in the outer Galaxy (R
GC = 12.9–23.5 kpc), using the 12 m telescope of the Arizona Radio Observatory. Methanol was detected in 19 out of 20 observed clouds, including sources as far as R
GC = 23.5 kpc. Identification was secured by the measurement of multiple asymmetry and torsional components in the J = 2 → 1 transition, which were resolved in the narrow line profiles observed (ΔV
1/2 ∼ 1–3 km s−1). From a radiative transfer analysis, column densities for these clouds of N
tot = 0.1–1.5 × 1013 cm−2 were derived, corresponding to fractional abundances, relative to H2, of f (CH3OH) ∼ 0.2–4.9 × 10−9. The analysis also indicates that these clouds are cold (T
K ∼ 10–25 K) and dense (n(H2) ∼ 106 cm−3), as found from previous H2CO observations. The methanol abundances in the outer Galaxy are comparable to those observed in colder molecular clouds in the solar neighborhood. The abundance of CH3OH therefore does not appear to decrease significantly with distances from the Galactic Center, even at R
GC ∼ 20–23 kpc. Furthermore, the production of methanol is apparently not affected by the decline in metallicity with galactocentric distance. These observations suggest that organic chemistry is prevalent in the outer Galaxy, and methanol and other organic molecules may serve to assess the GHZ.
European VLBI Network Observations of the Proposed Dual AGN SDSS J101022.95+141300.9
Authors: Veres Patrik Milán , Gabányi Krisztina Éva , Frey Sándor , Paragi Zsolt , Kun Emma , An Tao 
Published: November 2021

Abstract
During galaxy merger events, the supermassive black holes in the center of the galaxies may form a pair of active galactic nuclei (AGN) with kiloparsec-scale or even parsec-scale separation. Recently, optical observations revealed a promising dual-AGN candidate at the center of the galaxy SDSS J101022.95+141300.9 (hereafter J1010+1413). The presence of two distinct [O iii]-emitting point sources with a projected separation of ∼430 pc indicates a dual-AGN system. To search for AGN-dominated radio emission originating from the Hubble Space Telescope (HST) point sources, we carried out very long baseline interferometry observations. We resolved the radio structure of J1010+1413 and detected a single feature offset from the HST point sources and also from the Gaia optical position of the object. Our multiwavelength analysis of J1010+1413 inferred two possible interpretations of the observed properties challenging its proposed dual-AGN classification.
Multiple CNN Variants and Ensemble Learning for Sunspot Group Classification by Magnetic Type
Authors: Tang Rongxin , Zeng Xunwen , Chen Zhou , Liao Wenti , Wang Jingsong , Luo Bingxian , Chen Yanhong , Cui Yanmei , Zhou Meng , Deng Xiaohua , Li Haimeng , Yuan Kai , Hong Sheng , Wu Zhiping 
Published: November 2021

Abstract
A solar active region is a source of disturbance for the Sun–terrestrial space environment and usually causes extreme space weather, such as geomagnetic storms. The main indicator of an active region is sunspots. Certain types of sunspots are related to extreme space weather caused by eruptive events such as coronal mass ejections or solar flares. Thus, the automatic classification of sunspot groups is helpful to predict solar activity quickly and accurately. This paper completed the automatic classification of a sunspot group data set based on the Mount Wilson classification scheme, which contains continuum and magnetogram images provided by the Solar Dynamics Observatory’s Helioseismic and Magnetic Imager SHARP data from 2010 May 1 to 2017 December 12. After applying some data preprocessing steps such as image cropping and data standardization, the features of magnetic type in the data are more obvious, and the amount of data is increased. The processed data are spliced into two frames of single-channel data for the neural network to perform 3D convolution operations. This paper constructs a variety of convolutional neural networks with different structures and numbers of layers, selects 10 models as representatives, and chooses XGBoost, which is commonly used in ensemble-learning algorithms, to fuse the results of independent classification models. We found that XGBoost is an effective way to fuse models, which is proved by the relatively balanced high scores in the three magnetic types. The accuracy of the ensemble model is above 92%. The F1 scores of the magnetic types of Alpha, Beta, and Beta-x reached 0.95, 0.91, and 0.82 respectively.
New distribution records, first host plant record and DNA barcoding of the Neotropical plume moth Oidaematophorus pseudotrachyphloeus Gielis (Lepidoptera, Pterophoridae)
Authors: Vargas Héctor 
Published: November 2021

Oidaematophorus pseudotrachyphloeusGielis, 2011 (Lepidoptera, Pterophoridae) is a little-known Neotropical plume moth previously recorded in Ecuador, Peru and Argentina. Its host plants and DNA barcodes are unknown.Oidaematophorus pseudotrachyphloeusis recorded for the first time from Chile, based on six specimens from the Azapa Valley (Arica Province) and two from Guayacán (Coquimbo Province). Those from the Azapa Valley were reared from folivorous larvae collected onAmbrosia cumanensisKunth (Asteraceae), representing the first host plant record for this plume moth. The first DNA barcode sequences ofO. pseudotrachyphloeusare provided and used to explore relationships with congenerics.
Ion channels alterations in the forebrain of high-fat diet fed rats
Authors: Roy Proshanta , Martinelli Ilenia , Moruzzi Michele , Maggi Federica , Amantini Consuelo , Micioni Di Bonaventura Maria Vittoria , Cifani Carlo , Amenta Francesco , Tayebati Seyed Khosrow , Tomassoni Daniele 
Published: November 2021

Evidence suggests that transient receptor potential (TRP) ion channels dysfunction significantly contributes to the physiopathology of metabolic and neurological disorders. Dysregulation in functions and expression in genes encoding the TRP channels cause several inherited diseases in humans (the so-called ‘TRP channelopathies’), which affect the cardiovascular, renal, skeletal, and nervous systems. This study aimed to evaluate the expression of ion channels in the forebrain of rats with diet-induced obesity (DIO). DIO rats were studied after 17 weeks under a hypercaloric diet (high-fat diet, HFD) and were compared to the control rats with a standard diet (CHOW). To determine the systemic effects of HFD exposure, we examined food intake, fat mass content, fasting glycemia, insulin levels, cholesterol, and triglycerides. qRT-PCR, Western blot, and immunochemistry analysis were performed in the frontal cortex (FC) and hippocampus (HIP). After 17 weeks of HFD, DIO rats increased their body weight significantly compared to the CHOW rats. In DIO rats, TRPC1 and TRPC6 were upregulated in the HIP, while they were downregulated in the FC. In the case of TRPM2 expression, instead was increased both in the HIP and in the FC. These could be related to the increase of proteins and nucleic acid oxidation. TRPV1 and TRPV2 gene expression showed no differences both in the FC and HIP. In general, qRT-PCR analyses were confirmed by Western blot analysis. Immunohistochemical procedures highlighted the expression of the channels in the cell body of neurons and axons, particularly for the TRPC1 and TRPC6. The alterations of TRP channel expression could be related to the activation of glial cells or the neurodegenerative process presented in the brain of the DIO rat highlighted with post synaptic protein (PSD 95) alterations. The availability of suitable animal models may be useful for studying possible pharmacological treatments to counter obesity-induced brain injury. The identified changes in DIO rats may represent the first insight to characterize the neuronal alterations occurring in obesity. Further investigations are necessary to characterize the role of TRP channels in the regulation of synaptic plasticity and obesity-related cognitive decline.
Adverse Effects of Using Masks, Sanitizer, and Gloves Among Healthcare Workers In A Tertiary Care Center During the Covid-19 Pandemic
Authors: Anand Anju , Narayanan Namratha K. , Pradeep Midhuna , Shanavas Nandana , Anil Anuvinda , Bhavani Nisha , Nair Anjana S. 
Published: November 2021

Background and Objectives:
The ongoing coronavirus pandemic was first identified in Wuhan, Hubei, China on December 2019. India reported its first case on January 30, 2020 in Kerala. As COVID-19 is mostly a droplet infection, it necessitates the use of masks, gloves, and sanitizers for containing its spread. This study aims to understand the potential adverse effects of constant use of masks, gloves, and sanitizers among healthcare workers (HCWs).

Materials and Methods:
This is a cross-sectional study conducted among 165 HCWs from a single tertiary healthcare center in Kerala using a validated questionnaire. Data were analyzed using Microsoft Excel and SPSS version 20.

Results:
Among 165 participants, the most common adverse effects due to mask usage were dermatological in nature (57%). With regard to sanitizers, majority experienced dryness of hands (53.3%). Gloves were well tolerated with 62% of the participants reporting no adverse effects.

Conclusion:
Prolonged use of mask, sanitizer, and gloves has caused adverse effects in majority of HCWs surveyed. As the pandemic still stands as a crisis, it is necessary to identify solutions to manage these adverse effects for the betterment of the health of our HCWs.
Roles of hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha, a lipid metabolism enzyme, in Wilms tumor patients
Authors: Wu Xiangyu , Feng Run , Wang Xiaoqing , Guo Feng , Liu Wei 
Published: November 2021

Objectives:
Wilms tumor is a common pediatric malignant tumor that accounts for approximately 95% of kidney tumors in children. The role of lipid metabolism in tumors has attracted increased attention in recent years. We examined the role of hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA), a lipid metabolism enzyme, in the pathogenesis of Wilms tumor.

Materials and Methods:
In a previous study, we screened Wilms tumors and adjacent normal tissues for differentially expressed proteins by mass spectrometry and verified the results by western blot analysis. The Oncomine database and quantitative reverse transcription–polymerase chain reaction were used to verify the expression of HADHA at the genetic level. Immunohistochemistry and immunofluorescence were also used to validate the differential expression of the HADHA protein. The relationship between histopathological typing, clinical pathology, and HADHA expression was analyzed in 65 paraffin-embedded specimens from pediatric Wilms tumor patients. Kaplan–Meier survival curves were used to analyze the relationship between the expression of HADHA and patient prognosis.

Results:
HADHA was expressed at low levels in Wilms tumor tissue compared with the corresponding normal tissue. The expression of HADHA was closely associated with histopathological typing (P = 0.030). The prognostic analysis of 65 children with Wilms tumor showed that high expression of HADHA was closely associated with poor prognosis (P = 0.046).

Conclusions:
HADHA expression is downregulated in Wilms tumor tissues, but high expression in tumor tissues is associated with clinical stage and the prognosis of children with this tumor.
Successful treatment with durvalumab: A case report and review
Authors: Peláez Bejarano Ana , Montero Pérez Olalla 
Published: November 2021

ABSTRACT
Stage III non-small-cell lung cancer (NSCLC) represents a heterogeneous group of disease entities with multimodality treatments. For most patients, platinum-based doublet with concurrent chemoradiotherapy (CRT) has become the first-choice treatment over the past decade. Immune checkpoint inhibition has revolutionized the management of metastatic NSCLC; however, no major advances in systemic therapy for Stage III NSCLC have been made. The following report is the case of a patient with unresectable Stage IIIA NSCLC successfully treated with durvalumab. The patient completed 1 year of treatment without interruptions, and disease control has been maintained for more than 20 months since the start of durvalumab.
Soft-Chewable Paracetamol Tablets by Melt Granulation Method
Authors: Sabere Awis Sukarni Mohmad , Suhaimi Nur Anis Najlaa Mohd , Ahmed Qamar Uddin , Mahat Mohd Muzamir , Roslan Nazreen Che , Azizi Juzaili 
Published: November 2021

Background:
Oral drug delivery is the most preferred route for drug administration in the world, with tablets being one of the most common dosage forms. However, some people, particularly children and the elderly, have difficulty swallowing the tablets. Chewable tablets are the dosage form that can address the issue while also providing a valuable masking effect on drug taste, allowing patients to swallow the drugs more easily.

Materials and Methods:
In this study, the chewable tablets were manufactured using the melt granulation method, which resulted in tablets with a chewy texture. The tablets contained paracetamol as well as Arabic gum, starch, agar, and mannitol.

Results:
The drug release profiles for the fragmented form showed that 50% of the drug was released within 4 min and 100% was released within 30 min of the dissolution process. The intact form released nearly 90% of the drug within 2 h.

Conclusion:
Formulation 2 was determined as the best formulation. This tablets' formulation had passed all characterization tests and displayed a moderate hardness and chewy texture.
Impacts of dam construction on the macroinvertebrate community in the Poxin-Açú, in a tropical region
Authors: Vasco Anderson Nascimento do , Oliveira Amanda Vaz de Souza , Feitosa Geovane Alves , Araújo-Piovezan Talita Guimarães , Alves Agripino Emanuel Oliveira , Dantas José Oliveira 
Published: November 2021

River regularization plays an important role in socio economic development. However, it also modifies the natural flow system of the river and its biotic and abiotic characteristics, causing significant impacts on rivers. To evaluate the impacts on the macroinvertebrate community caused by dam construction on the Poxim-Açú River, metrics of composition and community structure of the macroinvertebrates were analyzed, as well as ecological and biological traits of the region. Macroinvertebrates were collected at three sites located downstream the dam, before (2013) and after (2015) dam construction. The water quality was classified as “good” to “excellent” according to the biotics indices. The alterations of the flow regime of the river after the dam construction influenced the macroinvertebrate communities, modifying their diversity, equitability, richness, and the number of individuals.
Keywords: bioindicators, dam impacts, environmental monitoring.
Low-cost material as active substrates for the removal of phosphorus in synthetic effluents: a proposal for social treatment technology
Authors: Soares Ana Caroline da Silva , Naval Liliana Pena 
Published: November 2021

Considering the importance of the development of simplified technologies and social control in sanitation actions, this study investigated the use of laterite for phosphorus removal in synthetic effluents, through adsorption, as a low-cost alternative with the possibility of reusing the generated effluent, for communities where access to sanitation is limited. In the experimental design, the variables pH, contact time, granulometry and laterite dosage were used. Factorial planning was used for processing, for optimization and desirability. It was observed that the removal efficiency did not have significant interference in relation to the pH and contact-time variables. The kinetics of the batch experiments showed that the ideal contact time was 6.4 hours and pH of around 4. The adsorption capacity was plotted against equilibrium concentration for the Freundlich and Langmuir isotherms. The Langmuir isotherm was more suitable for phosphorus adsorption. The results show that laterite was effective in phosphorus adsorption in the order of removal of 87%, showing itself to be a potential adsorbent material.
Keywords: laterite, phosphate adsorption, simplified effluent treatment.
Case Report: Chronic Cavitatory Pulmonary Aspergillosis after COVID-19
Authors: Chaurasia Sheetal , Thimmappa Manjunath , Chowdhury Saurav 
Published: November 2021

ABSTRACT.
Chronic pulmonary aspergillosis can present in four distinct clinical syndromes, one of which is chronic cavitary pulmonary aspergillosis (CCPA). CCPA is generally associated with a mildly immunosuppressed state or, in immunocompetent patients, with structural lung damage. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with reactivation of previous quiescent infections such as tuberculosis and invasive fungal infections, but CCPA in a patient with COVID-19 is rarely reported. Here we present the case of a 57-year-old man with CCPA associated with COVID-19 infection in whom latent aspergilloma was most likely activated after SARS-CoV-2 infection. The patient presented with severe COVID and, after initial response to treatment, started to deteriorate due to reactivation of latent aspergilloma to a more aggressive CCPA form. After confirmation of the diagnosis, the patient was initiated on treatment with voriconazole. He showed a good response to treatment with clinicoradiological response. This case also depicts one of the common causes of clinical deterioration in otherwise recovering COVID-19 patients.
Effect of methanol extract of Anacardium occidentale stem bark on agonist-induced contraction in rat uterine muscle
Authors: Omolaso B. O. 
Published: November 2021

Anacardium occidentale (Ao) is widely used in ethnomedicine and the effect on contractility of the gut and heart muscles of laboratory rodents have been established however, its effect on the contractility of uterine muscle has been rarely researched. The present study investigated the effect of stem bark methanolic extract of Anacardium occidentale (AoME) on Isolated Rat Uterus Strips (IRUS). The Anacardium occidentale methanol extract (AoME) was obtained by solvent extraction. The IRUS were suspended in a bath containing 15 ml of De Jalon's solution through a silk connected to a force transducer. A tension of 1.0 g was applied. The strips were allowed to equilibrate for a period of 60–90 min before the commencement of the experiment. The extract (0.025- 0.3mg/ml) added cumulatively did not modify the normal tonus in most of the IRUS used except in one where it feebly contracted it. However, the contractile responses induced by acetylcholine (10-9 -10-5 M) and oxytocin (10-9 -10-5 M) on the IRUS were almost completely blocked by pre-incubated AoME at a concentration of 0.2 mg/ml. Stem bark methanol extract of Anacardium occidentale shifted the log concentration curve of both agonists to the right. The present results report the antagonistic effects of stem bark methanol extract of Anacardium occidentale on oxytocin and acetylcholine-induced contraction in rat uterus strips.
Keywords: Anacardium occidentale, Oxytocin, Acetylcholine, Uterus, Smooth muscle
Modelling and optimization of metals (As, Ca, Cd, Cr, Cu, Fe, Mg, and Pb) and Ethylene glycol butyl ether in paints using response surface method
Authors: Apanpa-Qasim A. F. I. , Adeyi A. O. , Deshmukh Sharvari 
Published: November 2021

Response surface methodology (RSM) and principal component analyses (PCA) modelling tools have been used in this study to quantitatively describe the interaction effects of more than one factor on system response for the modelling and optimization of experimental data. In Nigeria, there are no stringent policies in place by the government on paint production and this has led to unregulated paint products by producers in the commercial markets. Water-based paints currently available in Nigerian market were sampled. Experimental data of Metals (As, Ca, Cd, Cr, Cu, Fe, Mg, and Pb) and Ethylene glycol butyl ether (Volatile organic compounds (VOC)) measured using Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES) and Gas Chromatography-Flame Ionisation Detector (GC-FID), respectively was used to develop a mathematical model. The principal component analyses were explained with a cumulative variance of 82% for the VOC and 76% for metals based on manufacturers. Estimated responses were compared with the experimentally determined responses and prediction capabilities of Response Surface Methodology. In the RSM, the 2 developed model had R value of 0.9569, with optimized value at 0.10 % (1000ppm) of Ethylene glycol butyl ether and concentration (ppm) ranges of As (383.0-1,930.0), Ca (614.0-10,400.0), Cd (98.0-2,000.0), Cr (10.3- 225.0), Cu (133.0-1,840.0), Fe 742.0-2,910.0, Mg (4,000.0-99,510.0), Pb (170.0-3,230.0). The correlation and optimization study employed are applicable for assessing the impact of hazardous air pollutants on indoor air quality and a good applicability in paint industries to produce products within the set limit of international standards. For the purpose of reducing sick building syndrome and protecting public health, it was important to investigate paints and sealers extensively.
Keywords: VOCs; Paint; metals; Ethylene glycol butyl ether; Response Surface Method
The Role of the Association of Colleges and Technical Schools of Transport in Industry Education
Authors: Razinkin N. I. 
Published: November 2021

The role of the non-profit organization “Association of colleges and technical schools of transport” in solving problems related to the modernization of transport education is considered. Today the Association is an effective tool for feedback with educational organizations in promoting innovative projects in the field of education.Association pays special attention to coordinating the development of new industry competencies WorldSkills.The need for the creation of new competencies is revealed, as a rule, in preparation for a new championship cycle, the introduction of demonstration exam technologies or the development of the championship movement in production, in a region or a university.The idea of joining efforts with colleges and technical schools of sea and river transport of industrial university complexes within the framework of the Association, which is actively supported by the Ministry of Transport of Russia, is becoming significant. This is a further perspective, the next step in the development of the Association.To do together what we cannot do alone is the leitmotif of the activities of the Association, which opens up the opportunity for all members of the Association to reach new educational frontiers.