bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Technical and Informal Resources of Breast Cancer Patients From 2012 to 2020: Questionnaire-Based Longitudinal Trend Study
Authors: Mallmann Christoph A , Domröse Christian M , Schröder Lars , Engelhardt David , Bach Frederik , Rueckel Helena , Abramian Alina , Kaiser Christina , Mustea Alexander , Faridi Andree , Malter Wolfram , Mallmann Peter , Rudlowski Christian , Zivanovic Oliver , Mallmann Michael R 
Published: March 2021

Background
Digitalization offers enormous potential in medicine. In the era of digitalization, the development of the use of digital, technical, and informal resources of breast cancer patients and factors influencing the degree of digitization of patients has been insufficiently researched.

Objective
The aim of this study was to assess the development of the use of digital technical and informal resources in a well-defined patient cohort.

Methods
A longitudinal study on 513 breast cancer patients from 2012 to 2020 was conducted using a questionnaire that included the main aspects of the degree of digitalization, including digital device availability and use, stationary and mobile internet access and use, and communication and information seeking regarding breast cancer diagnosis and treatment.

Results
The majority of patients (421/513, 82.1%) owned the technical resources to benefit from eHealth, used the internet to obtain information (292/509, 57.4%), and were willing to use new eHealth solutions (379/426, 89%). Two-thirds of the patients discussed information about their cancer on the internet with their doctor, one-third found additional treatment options on the internet, and 15.3% (44/287) of the patients stated that this had changed their cancer therapy. The degree of digitization is increasing yet still significantly depends on 3 factors: (1) age (whereas 100% [39/39] of the <59-year-old group used the internet in 2020, 92% of the 60 to 69-year-old group [11/12] and only 47% [6/13] of the >70-year-old group used the internet), (2) education (internet use significantly depended on education, as only 51.8% [59/114] of patients with primary school education used the internet, but 82.4% [126/153] with middle school education and 90.3% [213/236] with high school education used the internet; P<.001), and (3) household size (67.7% [111/164] of patients living alone used the internet, whereas 84.7% [287/339] of patients living in a house with ≥2 people used the internet; P<.001).

Conclusions
To implement digital solutions in health care, knowledge of the composition and degree of the use of digital technical and informal resources of the patient group for which the respective solution is developed is crucial for success.

Trial Registration
German Register of Clinical Studies DRKS00012364; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00012364
Investigating Associations Between Screen Time and Symptomatology in Individuals With Serious Mental Illness: Longitudinal Observational Study
Authors: Henson Philip , Rodriguez-Villa Elena , Torous John 
Published: March 2021

Background
Increasing screen time exposure from digital devices like smartphones has shown a variety of mixed associations with cognition, behavior, and well-being in adults and children but little is known about its associations with symptomatology in individuals with serious mental illness.

Objective
To determine the range of associations between screen time and symptoms of individuals with mental illness, we utilized a method called specification curve analysis.

Methods
In this observational study, we recruited smartphone-owning adults (≥18 years old) with schizophrenia and healthy controls. We installed 2 research-source smartphone apps, mindLAMP and Beiwe, to collect survey results, cognitive test results, and screen time metrics over a period of 3 months. Surveys were scheduled for twice a week, but participants were instructed to take the surveys naturally as much or as little as they wanted. Screen time was collected continuously in the background. A total of 140 participants was recruited from the outpatient clinic population as well as through general public advertising. Age-matched, smartphone-owning healthy controls were also part of the recruitment pool. A specification curve analysis was a priori designed to explore the relationship between every combination of independent variable and dependent variable in order to demonstrate to what degree screen time relates to symptoms in individuals with serious mental illness.

Results
The sample consisted of 88 participants (54 with schizophrenia and 34 healthy controls) who completed both the initial and follow-up visits, completed at least one self-reported survey, and had a minimum passive data cutoff of 5 consecutive days. While we found an association between smartphone screen time metrics and cognition (adjusted R2=0.107, P<.001), specification curve analysis revealed a wide range of heterogenous associations with screen time from very negative to very positive. The effects differed based on diagnostic group, age bracket, type of regression model used, and the specific independent and dependent variables selected for analysis.

Conclusions
The associations between screen time and mental health in patients with schizophrenia are heterogenous when examined with methods that reduce analytical bias. The heterogeneity in associations suggests that complex and personalized potential effects must be understood in the greater context of an individual. This analysis of longitudinally collected screen time data shows potential for future research that could benefit from high resolution metrics on smartphone use.
Spectral Analysis of One-Dimensional Dirac System with Summable Potential and Sturm- Liouville Operator with Distribution Coefficients
Authors: Savchuk A. M. , Sadovnichaya I. V 
Published: March 2021

We consider one-dimensional Dirac operatorLP,U with Birkhoff regular boundary conditions and summable potential P(x) on[0, ]. We introduce strongly and weakly regular operators. In both cases, asymptotic formulas for eigenvalues are found. In these formulas, we obtain main asymptotic terms and estimates for the second term. We specify these estimates depending on the functional class of the potential: Lp[0,] with p [1,2] and the Besov space Bp,p'[0,] with p [1,2] and (0,1/p). Additionally, we prove that our estimates are uniform on balls Pp,R Then we get asymptotic formulas for normalized eigenfunctions in the strongly regular case with the same residue estimates in uniform metric on x [0,]. In the weakly regular case, the eigenvalues 2n and 2n+1 are asymptotically close and we obtain similar estimates for two-dimensional Riesz projectors. Next, we prove the Riesz basis property in the space (L2[0,])2 for a system of eigenfunctions and associated functions of an arbitrary strongly regular operatorLP,U. In case of weak regularity, the Riesz basicity of two-dimensional subspaces is proved.
In parallel with theLP,U operator, we consider the SturmLiouville operator Lq,U generated by the differential -y'' + q(x)y expressionwith distribution potential q of first-order singularity (i.e., we assume that the primitive u = q(1) belongs to L2[0, ]) and Birkhoff-regular boundary conditions. We reduce to this case -(1y')'+i(y)'+iy'+0y, operators of more general form where '1,,0(-1)L2and 10. For operator Lq,U, we get the same results on the asymptotics of eigenvalues, eigenfunctions, and basicity as for operator LP,U .
Then, for the Dirac operator LP,U, we prove that the Riesz basis constant is uniform over the ballsPp,R for p1 or 0. The problem of conditional basicity is naturally generalized to the problem
of equiconvergence of spectral decompositions in various metrics. We prove the result on equiconvergence by varying three indices: fL[0,] (decomposable function), PL[0,] (potential), and Sm-Sm00,m in L[0,] (equiconvergence of spectral decompositions in the corresponding norm). In conclusion, we prove theorems on conditional and unconditional basicity of the system of eigenfunctions and associated functions of operator LP,U in the spaces L[0,],2, and in various Besov spaces Bp,q[0,].
PENYULUHAN TENTANG PENCEGAHAN PENULARAN MALARIA DENGAN METODE ROLE PLAY DI KABUPATEN KULON PROGO DAERAH ISTIMEWA YOGYAKARTA TAHUN 2019
Authors: Trapsilowati Wiwik , Widiarti Widiarti , Pujiyanti Aryani , Setiyaningsih Riyani 
Published: March 2021

The success of the partnership program and community-based health services needs to be supported by information, education, and communication (IEC) to increase the community and stakeholder’s knowledge. The IEC has often carried out lectures and question answers (QA). It needs another method, one of them is role play. The aim of this study was to describe the knowledge enhancement about malaria using the role-play method. This research was a quasi-experimental study with the pretest-posttest method without a control design. The form of intervention was health education using role-play method with analysis using the Wilcoxon sign rank test. The total pretest and posttest scores were significantly different (p <0.05). The number of items of evaluation questions was 10 items. Knowledge of 6 items; symptoms, causes, consequences of malaria, risky activities, time for blood tests, and the person in charge of migration surveillance, had a significant increase, while 4 items; mode of transmission, a migration surveillance mechanism, and the suspect's investigator had an insignificant increase. The application of the role-play method was proven to significantly increase participants' knowledge of malaria. A suggestion is necessary to increase public knowledge in the field of health, especially malaria through non-monotonous methods so that people are more interested and have optimal results.
Abstrak
Keberhasilan program kemitraan dan layanan kesehatan berbasis masyarakat perlu didukung kegiatan komunikasi, informasi dan edukasi (KIE) sebagai upaya meningkatkan pengetahuan masyarakat dan pemangku kepentingan lainnya. Kegiatan KIE yang sering dilakukan adalah ceramah dan tanya jawab, sehingga perlu metode lain yang berbeda yaitu role play. Tujuan penelitian ini adalah mendeskripsikan peningkatan pengetahuan tentang malaria dengan metode role play. Penelitian ini merupakan penelitian eksperimental semu dengan metode pretest-postest without control design. Bentuk intervensi adalah penyuluhan menggunakan metode role play dengan analisis menggunakan Wilcoxon sign rank test. Total nilai pretest dan post test ada perbedaaan secara signifikan (p<0,05). Jumlah item pertanyaan evaluasi sebanyak 10 butir, 6 item ; gejala, penyebab, akibat sakit malaria, aktivitas berisiko, waktu pemeriksaan darah dan penanggung jawab surveilans migrasi, memiliki peningkatan yang signifikan, sedang 4 item yaitu cara penularan, alur surveilans migrasi dan petugas pemeriksa tersangka mengalami peningkatan yang tidak signifikan. Penerapan metode role play terbukti dapat meningkatkan pengetahuan peserta tentang malaria secara signifikan. Sebagai saran perlu upaya peningkatan pengetahuan masyarakat dalam bidang kesehatan, khususnya malaria melalui metode yang tidak monoton, agar masyarakat lebih tertarik dan hasil yang optimal.
DEMOGRAPHIC STUDY ON SMARTPHONE PREFERENCE AMONG STUDENTS IN NIGERIAN UNIVERSITIES
Authors: Adekunle Simon Ayo , Dimowo Oiza Lauren 
Published: March 2021

This study investigated smartphone preference among undergraduate and postgraduate students in Nigerian universities. Specifically, the study examined the extent to which students’ demographic attributes such as gender, age, usage experience and educational level influence their preference for smartphones. The study also identified and ranked smartphone brands based on selected factors like brand name, brand attachment, perceived usefulness, social influence, price, aesthetic value and product design and features. A cross-sectional survey research design was used for the study. The study population comprised all full-time university students in Nigeria both at undergraduate and postgraduate levels. Questionnaire was designed and electronically administered using Google Form to the target respondents. After three weeks (10th June to 1st July 2020), five hundred and forty-three (543) responses were collated. However, seventy-eight (78) were found to be invalid. As a result, four hundred and sixty-five (465) responses that formed the sample size were used for the study. The data collected were statistically analyzed using frequency table, percentages, mean, standard deviation and t-test with the aid of Statistical Packages for Social Sciences (SPSS) software. The study found that Samsung is the most preferred smartphone among students. It was also revealed that the first three most important factors that influence students' preference for smartphones are brand name, perceived usefulness, and design/features. The study revealed that demographic attributes do not significantly influence smartphone preference among university students. The study, therefore, recommends that demographic attributes such as gender, age, usage experience and programme should not be significantly considered by manufacturers and marketers of smartphones in product differentiation.
Keywords: Brand name, demographics, preference, smartphone, students.
BIOMEDICINSKI ULOŽAK ZA CIPELE ZA KOREKCIJU HODA KOD DECE
Authors: Kostovski Aleksandar 
Published: March 2021

Kako bi se sprečile deformacije hoda u kasnijem dobu, u ovome radu predstavljen je „Biomedicinski uređaj za cipele za korekciju hoda kod dece“ kako bi se popravila statika čitavog tela i smanjio pritisak u svim zglobovima iznad stopala (skočni, koleno i kukovi). U prvom delu rada predstavljena je ideja kako obezbediti uređaj koji će dete usmeravati da pravilno hoda, dok se drugi deo rada sastoji od proof – of - concepta samog uređaja.
Botanical Characteristics of Balanophora SP. Balanophoraceae
Authors: Thanh Ha Tuan Nguyen , Hong Hai Nguyen , Cong Bang Nguyen , Thi Hai Yen Nguyen , Thi Thu Hang Nguyen , Thi Ha Van Quach 
Published: March 2021

From the past up to now, Balanophora sp. has been used by the Dao as a valuable remedyfor bones and joints such as back pain, paralysis of limbs, sexual improvement, strengthening ... Thisprecious medicinal plant grows and develops well in marble forests, at an altitude of over 1500 meters above sea level, found most in some northern mountainous areas such as Yen Bai, Lao Cai, Cao Bang, Hoa Binh, Ha Giang, Son. La…. In this research, we described and systemized data on morphology,microscopy characteristics of Vietnamese Balanophora sp. . The obtained results show that the Balanophora sp. in Cao Bang province, scientifically named Balanophora indica (Arnott) Griff, belongs to the Balanophoraceae, which have built a relatively complete data set on anatomy andmicro-anatomy characteristics of roots, leaves, whole-plant medicinal powder. The results of this study contribute to completing the monographs of the Balanophora indica (Arnott) Griff in the Vietnamese Pharmacopoeia.
Keywords
Balanophora sp.; balanophoraceae; morphological; microscopy.
References
[1] Ministry of Health. Vietnam Pharmacopoeia V, 2017, PL12.18 (in Vietnamese).[2] P.H. Hộ. All Illustrated Flora of Vietnam J. Tre, Ho Chi Minh (2003) 140 (in Vietnamese),[3] D.H. Bich, Medicinal Plants and Animals in Vietnam Science and Technics Publishing House, National Institue of Medicinal Materials 1 (2002) 555 (in Vietnamese),[4] X. Wang, Z. Liu, W. Qiao, R. Cheng, B. Liu and G. Shel, Phytochemicals and biological studies of plants from the genus Balanophora, Chemistry Central Journal (2012) 6-79.
Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis
Authors: Girisha Banavasi Shanmukha , Shibina Shajahan , Raghuraja U , Subramanyam K 
Published: March 2021

Background:
Carotid intima-media thickness test is a surrogate marker of subclinical atherosclerosis. Epicardial fat thickness is an early marker of coronary artery disease. Several studies have noted that psoriasis patients have an increased risk of coronary artery disease. In the present study, we attempted to see any variation in carotid intima-media thickness and epicardial fat thickness in psoriasis patients when compared to controls.

Aims:
1) To determine the carotid intima-media thickness and epicardial fat thickness in psoriatic patients and healthy controls. 2) To evaluate the association between carotid intima-media thickness and epicardial fat thickness in psoriasis patients.

Methods:
A hospital-based study with 100 subjects (50 with psoriasis and 50 healthy controls) was conducted in the Dermatology Outpatient Department of Justice KS Hegde Charitable Hospital, a unit of KS Hegde Medical Academy affiliated to NITTE (Deemed to be University) Mangaluru. A detailed history and examination including body mass index, psoriasis area and severity index were done. Carotid ultrasound was done to measure carotid intima-media thickness and transthoracic echocardiography was done to assess epicardial fat thickness in both cases and controls. Independent sample t-test, Pearson rank correlation (r) coefficient were used for statistical analysis. P-value <0.05 was considered statistically significant. IBM Statistical Package for the Social Sciences version 22 Armonk, NY: IBM Corp was used for statistical analysis.

Results:
Mean carotid intima-media thickness in the right carotid ([0.51 ± 0.1mm vs 0.47 ± 0.1 mm] [P = 0.038]) and left carotid ([0.53 ± 0.12 mm vs 0.48 ± 0.1 mm] [P = 0.041]) were significantly increased in psoriasis patients than in controls. Mean epicardial fat thickness was significantly increased ([1.76 ± 0.66 mm vs. 1.49 ± 0.47 mm] ([P = 0.020]) in patients with psoriasis when compared with the controls. Epicardial fat thickness was positively correlated with carotid intima-media thickness in patients with psoriasis.

Limitations:
The cross-sectional design of the study, smoking among study subjects, inter and intraobserver variability of measurement of epicardial fat thickness and carotid intima-media thickness.

Conclusion:
Carotid intima-media thickness and epicardial fat thickness were increased in psoriasis patients when compared with healthy controls. Epicardial fat thickness was positively correlated with carotid intima-media thickness in cases.
Six Low-Lying Isomers of C11H8 Are Unidentified in the Laboratory - a Theoretical Study
Authors: Roy Tarun , Ghosal Subhas , Thimmakondu Venkatesan S. 
Published: March 2021

The potential energy surface of C11H8 has been theoretically examined using density functional theory and coupled-cluster methods. The current investigation reveals that 2aH-cyclopenta[cd]indene (2), 7-ethynyl-1H-indene (6), 4-ethynyl-1H-indene (7), 6-ethynyl-1H-indene(8), 5-ethynyl-1H-indene (9), and 7bH-cyclopenta[cd]indene (10) remain elusive to date in the laboratory. The puckered low-lying isomer 2 lies at 11 kJ mol−1 below the experimentally known molecule, cyclobuta[de]naphthalene (3), at the fc-CCSD(T)/cc-pVTZ//fc-CCSD(T)/cc-pVDZ level of theory. 2 lies at 35 kJ mol−1 above the thermodynamically most stable and experimentally known isomer, 1H-cyclopenta[cd]indene (1), at the same level. It is identified that 1,2-H transfer from 1 yields 2H-cyclopenta[cd]indene (14) and subsequent 1,2-H shift from 14 yields 2. Appropriate transition states have been identified and intrinsic reaction coordinate calculations have been done at the B3LYP/6-311+G(d,p) level of theory. Recently, 1-ethynyl-1H-indene (11) has been detected using synchrotron based vacuum ultraviolet ionization mass spectrometry. 2-ethynyl-1H-indene (4) and 3-ethynyl-1H-indene (5) have been synthetically characterized in the past. While the derivatives of 7bH-cyclopenta[cd]indene (10) have been isolated elsewhere, theparent compound remains unidentified to date in the laboratory. Although C11H8 is a key elemental composition in reactive intermediates chemistry and most of its isomers are having a non-zero dipole moment, to the best of our knowledge, none of them have been characterized by rotational spectroscopy. Therefore, energetic and spectroscopic properties have been computed and the present investigation necessitates new synthetic studies on C11H8, in particular 2, 6-10, and also rotational spectroscopic studies on all low-lying isomers.
Formulation and evaluation of Olmesartan Medoxomil solid dispersions to enhance its solubility and dissolution characteristics
Authors: Christopher Vimalson D  , Parimalakrishnan S  , Jeganathan N S  , Anbazhagan S  
Published: March 2021

The objective of the present learns to improve solubility and dissolution of Olmesartan Medoxomil (OM) by improving water solubility by reliable dispersion methods using fusion method (FM) and solvent evaporation (SE) method via hydrophilic polymers PEG 6000 and PVP K30 in different ratios. Preformulation studies of OM: polymers were carried using DSC and FTIR proves that it is stable without any extra peaks, which implies no interaction among the drug and carrier. For OM in FM drug: polymer ratio was maintained in a range 1:1, 1:3, 1:5 and 1:7 w/w ratio of OM to PEG 6000 and coded as SDOM1, SDOM2, SDOM3 and SDOM4 whereas for SE method OM to PVP K30 ratio was maintained in a range of 1:1, 1:3, 1:5 and 1:7 w/w ratio and coded as SDOM5, SDOM6, SDOM7 and SDOM8. SDOM3 by FM and SDOM7 by SE method resulted in the highest production yield. The solubility studies have shown improved drug solubility compared with a pure drug in all medium. Percentage of drug content, flowability characters like the angle of repose and carr's index, bulk density, Hausner's, tapped density were within acceptable limits. In vitro drug release in the intestinal gastric medium of pH 1.2 was improved significantly when compared with pure drug. SDOM3 and SDOM7, selected for accelerated stability studies, had no significant change in physical parameters, drug content, with little changes in the in vitro drug release pattern. Hence solubility and dissolution rate of OM is increased by using the PEG 6000 and PVP K30 polymers.
Pengembangan panduan konseling Islami berbasis model Gerald Corey
Authors: Ermalianti Ermalianti 
Published: March 2021

Penelitian ini dilatarbelakangi oleh ketiadaan panduan konseling Islami yang jelas dan sistematis. Tujuan penelitian adalah mengembangkan panduan konseling Islami berbasis Model Gerald Corey. Penelitian menggunakan penelitian dan pengembangan (R & D) berdasarkan model Bord & Gall dengan modifikasi oleh Sukmadinata. Tahap pengembangan meliputi: studi pendahuluan, pengembangan produk, validasi ahli dan pengguna. Teknik pengumpulan data terdiri dari kuisioner, observasi dan wawancara. Jenis data yang digunakan berupa data kuantitatif dan kualitatif. Hasil uji validasi Panduan konseling Islami berbasis Model Gerald Corey dari para ahli dan para calon pengguna menunjukkan nilai rata-rata empat (4) dengan kategori sangat tepat/sesuai. Dengan demikian, panduan koseling Islami berdasarkan model Gerald Corey telah memenuhi kriteria sangat tepat/sesuai dan layak untuk dipergunakan.