bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatially and temporally distributed data foraging decisions in disciplinary field science
Authors: Wilson Cristina G. , Qian Feifei , Jerolmack Douglas J. , Roberts Sonia , Ham Jonathan , Koditschek Daniel , Shipley Thomas F. 
Published: April 2021

AbstractHow do scientists generate and weight candidate queries for hypothesis testing, and how does learning from observations or experimental data impact query selection? Field sciences offer a compelling context to ask these questions because query selection and adaptation involves consideration of the spatiotemporal arrangement of data, and therefore closely parallels classic search and foraging behavior. Here we conduct a novel simulated data foraging study—and a complementary real-world case study—to determine how spatiotemporal data collection decisions are made in field sciences, and how search is adapted in response to in-situ data. Expert geoscientists evaluated a hypothesis by collecting environmental data using a mobile robot. At any point, participants were able to stop the robot and change their search strategy or make a conclusion about the hypothesis. We identified spatiotemporal reasoning heuristics, to which scientists strongly anchored, displaying limited adaptation to new data. We analyzed two key decision factors: variable-space coverage, and fitting error to the hypothesis. We found that, despite varied search strategies, the majority of scientists made a conclusion as the fitting error converged. Scientists who made premature conclusions, due to insufficient variable-space coverage or before the fitting error stabilized, were more prone to incorrect conclusions. We found that novice undergraduates used the same heuristics as expert geoscientists in a simplified version of the scenario. We believe the findings from this study could be used to improve field science training in data foraging, and aid in the development of technologies to support data collection decisions.
Guillain-Barre syndrome after coronary artery bypass graft surgery: a case report and literature review
Authors: Hameed Sajid , Jafri Lubna Ashraf , Kanwar Dureshahwar 
Published: April 2021

Abstract
Background
Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy, often preceded by an infection. Rarely, it is preceded by a surgical procedure. Most of the postsurgical GBS cases are reported with the neurosurgical, gastrointestinal, orthopedic, and cardiac procedures. GBS is rarely reported after a coronary artery bypass grafting (CABG). To date, only 12 cases have been reported in the literature. Our case is 13th in number and the first case from Pakistan.

Case presentation
We report a case of a 54-year-old man presented with acute flaccid quadriparesis and areflexia after a CABG procedure. He was subsequently diagnosed with an acute inflammatory demyelinating polyneuropathy (AIDP) variant of GBS and underwent five sessions of plasmapheresis. His weakness improved and could ambulate unassisted on follow-up visits.

Conclusion
GBS is a potentially treatable condition if timely diagnosed and managed. It should be considered in every patient presenting with an acute-onset weakness after surgery.
New technique for false lumen coiling of spontaneous isolated superior mesenteric artery dissection
Authors: Yamaguchi Hidenori , Murata Satoru , Ueda Tatsuo , Mine Takahiko , Onozawa Shiro , Hayashi Hiromitsu , Kumita Shin-ichiro 
Published: April 2021

Abstract
Background
Spontaneous isolated visceral artery dissection is rarely encountered. Endovascular intervention with good outcomes has become popular for patients with persistent symptoms or developing ischemia. We could perform life-saving treatment for a spontaneous isolated superior mesenteric artery dissection with a unique endovascular intervention.

Case presentation
We describe the case of an 80-year-old man who presented with acute abdominal pain and a spontaneous isolated superior mesenteric artery dissection measuring 35 mm in major diameter and 6.6 mm in minor diameter on abdominal contrast-enhanced computed tomography. After admission, abdominal pain was progressive, and a repeated scan revealed progression of the dissection. As an endovascular intervention, via the bilateral femoral approach, detachable coils were placed in the false lumen of the superior mesenteric artery dissection through the false lumen under the micro-balloon occlusion at the point of re-entry and entry through the true lumen to prevent coil migration. Technical and clinical success was achieved without serious adverse events.

Conclusion
Coil embolization using micro-balloon assistance combined with the double-catheter technique for a large entry and re-entry false lumen of a spontaneous isolated superior mesenteric artery dissection was useful and feasible.
The growth response of rice (Oryza sativa L. var. FARO 44) in vitro after inoculation with bacterial isolates from a typical ferruginous ultisol
Authors: Ibrahim Musa Saheed , Ikhajiagbe Beckley 
Published: April 2021

Abstract
Background
Rice forms a significant portion of food consumed in most household worldwide. Rice production has been hampered by soil factors such as ferruginousity which has limited phosphorus availability; an important mineral component for the growth and yield of rice. The presence of phosphate-solubilizing bacteria (PSB) in soils has been reported to enhance phosphate availability. In view of this, the present study employed three bacteria species (BCAC2, EMBF2 and BCAF1) that were previously isolated and proved P solubilization capacities as inocula to investigate the growth response of rice germinants in an in vitro setup. The bacteria isolates were first identified using 16S rRNA gene sequencing and then applied as inoculum. The inolula were prepared in three concentrations (10, 7.5 and 5.0 ml) following McFarland standard. Viable rice (var. FARO 44) seeds were sown in petri dishes and then inoculated with the three inocula at the different concentrations. The setup was studied for 28 days.

Results
16S rRNA gene sequencing identified the isolates as: isolate BCAC2= Bacillus cereus strain GGBSU-1, isolate BCAF1= Proteus mirabilis strain TL14-1 and isolate EMBF2= Klebsiella variicola strain AUH-KAM-9. Significant improvement in rice germination, morphology, physiology and biomass parameters in the bacteria-inoculated setups was observed compared to the control. Germination percentage after 4 days was 100 % in the inoculated rice germinants compared to 65% in the control (NiS). Similarly, inoculation with the test isolates enhanced water-use efficiency by over 40%. The rice seedlings inoculated with Bacillus cereus strain GGBSU-1 (BiS) showed no signs of chlorosis and necrosis throughout the study period as against those inoculated with Proteus mirabilis strain TL14-1 (PiS) and Klebsiella variicola strain AUH-KAM-9 (KiS). Significant increase in chlorophyll-a, chlorophyll-b and alpha amylase was observed in the rice seedlings inoculated with BiS as against the NiS.

Conclusion
Inoculating rice seeds with Bacillus cereus strain GGBSU-1, Proteus mirabilis strain TL14-1 and Klebsiella variicola strain AUH-KAM-9 in an in vitro media significantly improved growth parameters of the test plant. Bacillus cereus strain GGBSU-1 showed higher efficiency due to a more improved growth properties observed.
Heavy metal levels in cattle egrets (Bubulcus ibis) foraging in some abattoirs in Lagos State metropolis
Authors: Adegbe Elijah Abakpa , Babajide Oluwaseyi Oluwabukola , Maina Lois Riyo , Adeniji Shola Elijah 
Published: April 2021

Abstract
Background
Heavy metal accumulation in the ecosystem constitutes a potential toxic effect which is hazardous to human health. Increasing environmental pollution has necessitated the use of cattle egrets to evaluate the levels of heavy metal contamination, to establish their use in biomonitoring of heavy metals and to provide data for monitoring pollution in the environment.

Results
The present study assessed the utilization of Bubulcus ibis in monitoring pollution in five abattoirs, namely Agege, Bariga, Kara, Itire and Idi-Araba, all situated in Lagos State. The concentration of five (5) heavy metals, cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn) was determined in the liver, muscle and feather of Bubulcus ibis using the atomic absorption spectrophotometer. The trend of metal accumulation was in the order: Zn > Cu > Pb > Cd > Ni for all the sampled tissues. The mean tissue concentrations of the metals were significantly different (p < 0.05) among the sites. The highest levels of metal concentration were reported in the liver in all the locations. Mean concentration of Cd in Kara (0.003 ± 0.00058) was significantly (p < 0.05) higher than those found at Agege (0.0013 ± 0.00058) and Idi-Araba (0.001 ± 0.001). A significant difference (p < 0.05) was also observed between the mean concentrations of Cu in Bariga (0.01 ± 0.001) and Idi-Araba (0.003 ± 0.001).

Conclusion
All the studied heavy metals were present in the liver, muscle and feathers of the cattle egrets. The contamination levels were ascertained from the study which indicated that cattle egrets are useful in biomonitoring studies and the generated data will serve as baseline data which could be compared with data from other locations for monitoring heavy metal pollution.
Authorship trends in the Egyptian orthopedic journal (from 2012 to 2020), as an example of a specialized Egyptian medical journals
Authors: Khalifa Ahmed A. , El-Hawary Ahmed S. , Sadek Ahmed E. 
Published: April 2021

Abstract
Background
Authorship trends in medical journals were studied in many disciplines, mostly in western countries' journals. We aimed at studying the authorship trends in the Egyptian Orthopaedic Journal as an example of a specialized Egyptian medical journal.

Results
A total of 397 articles were eligible for analysis. The mean number of authors per article was 2 ± 1 (range from 1 to 6), 161 (40.6%) articles were single authorship. The degree of the first author was reported in 305 (76.6%), the first author carried an M.D. degree in 302 (99%) articles, and in three (1%), the first author carried a master’s degree. No authors with a bachelor's degree were reported. Forty-two institutions contributed to the publications, 14 (33.3%) international and 28 (66.7%) Egyptian national institutions. In 368 (92.7%) articles, all the authors were from the same institution, and 29 (7.3%) articles were published as a cooperation between different institutions with a mean 1.1 ± 0.3 institution per article. International contribution to the journal was found in 21 (5.3%) articles. The orthopedic department from Cairo university was the most contributing department to the journal publications.

Conclusions
The old trend of single authorship prevails in the journal publications with a notable deficiency in young researchers’ contribution to the journal and low incidence of international contribution and poor national institution cooperation.
Computer-assisted evaluation of plant-derived β-secretase inhibitors in Alzheimer’s disease
Authors: Ullah Md. Asad , Johora Fatema Tuz , Sarkar Bishajit , Araf Yusha , Ahmed Nafisa , Nahar Abida Nurun , Akter Tanzina 
Published: April 2021

Abstract
Background
Alzheimer’s disease (AD) is a progressive neurodegenerative age-related dementia that results in memory loss of elderly people. Many hypotheses have been formally articulated till now to decipher the pathogenesis of this disease. According to the compelling amyloidogenic hypothesis, β-secretase is a key regulatory enzyme in AD development and is therefore considered as one of the major targets for the development of drugs to treat AD. In this study, 40 plant-derived phytocompounds, proven to have β-secretase inhibitory activity in different laboratory experiments, were evaluated using computational approaches in order to identify the best possible β-secretase inhibitor(s).

Results
Amentoflavone (IFD score: − 7.842 Kcal/mol), Bilobetin (IFD score: − 7.417 Kcal/mol), and Ellagic acid (IFD score: − 6.923 Kcal/mol) showed highest β-secretase inhibitory activities with high binding affinity among all the selected phytocompounds and interacted with key amino acids, i.e., Asp32, Tyr71, and Asp228 in the catalytic site of β-secretase. Moreover, these three molecules exhibited promising results in different drug potential assessment experiments and displayed signs of correlation with significant pharmacological and biological activities.

Conclusion
Amentoflavone, Biolbetin, and Ellagic acid could be investigated further in developing β-secretase-dependent drug for the effective treatment of AD. However, additional in vivo and in vitro experiments might be required to strengthen the findings of this experiment.
Retrospective study of Dana Farber Consortium Protocol in newly diagnosed Egyptian adolescents and young adults with acute lymphoblastic leukemia: Tanta experience
Authors: Elashtokhy Hossam Eldin A. , Elgohary Heba E. , Eldeep Basant B. , Gaber Sally M. , Elbedewy Tamer A. 
Published: April 2021

Abstract
Background
Intensive acute lymphoblastic leukemia (ALL) regimens in children improve the 5-year event-free survival (EFS) to reach ~ 90%. Adolescents and young adults (AYA) have EFS (30% to 45%). Young AYA ALL patients treated with pediatric chemotherapy protocols such as Dana Farber Consortium Protocol (DFCP) experience a better prognosis. This study aimed to assess the efficacy [EFS and overall survival (OS)] and the toxicity of DFCP in the treatment of Egyptian AYA with newly diagnosed ALL. A retrospective study was performed on 41 patients with newly diagnosed ALL (15 and 39 years) who were treated with DFCP. EFS and OS were estimated using the Kaplan-Meier method.

Results
Thirty-eight patients (92.68%) achieved complete remission (CR). Eleven patients (26.83%) relapsed. Ten (24.39%) patients died. One, two, and three years of EFS were 75.61%, 72.91%, and 67.51% respectively. One, two, and three years OS were 85.3%, 77.26%, and 74.39% respectively. Neutropenia was the most common adverse event observed in 100% of patients.

Conclusion
DFCP can be considered as an effective ALL protocol for the AYA group of patients with good CR, EFS, and OS rates. DFCP seemed to be feasible in AYA despite the toxicities experienced.
The additive role of diffusion-weighted magnetic resonance imaging to axillary nodal status evaluation in cases of newly diagnosed breast cancer
Authors: Elmesidy Dalia Salaheldin , Badawy Eman Ahmed Mohammed Omar , Kamal Rasha Mohammed , Khallaf Emad Salah Eldin , AbdelRahman Rasha Wessam 
Published: April 2021

Abstract
Background
Axillary nodal status is crucial for the management of cases with recently diagnosed breast cancer; usually addressed via axillary ultrasonography (US) along with tissue sampling in case of suspicion. Axillary nodal dissection and sentinel biopsy may be done, but are rather invasive, carrying a potential complication risk, which raises the need for non-invasive, reliable, pre-operative axillary imaging. We aimed at evaluating the performance of diffusion-weighted imaging (DWI) regarding preoperative axillary evaluation, using functional information derived from diffusion capacity differences between benign and malignant tissue. We included 77 axillary nodes from 77 patients (age range 20–78 years, mean 50 ± 12.6 SD) in our prospective study, presenting with variable clinical breast complaints, all scoring BIRADS 4/5 on sonomammography (SM). They underwent axillary evaluation by both US and DW-MRI where US classified nodes into benign, indeterminate, or malignant by evaluating nodal size, shape, cortical thickness, and hilar fat. Qualitative DWI classified them into either restricted or not and a cut-off apparent diffusion coefficient (ADC) value was calculated to differentiate benign and malignant nodal involvement. Results for each modality were correlated to those of final histopathology, which served as the standard of reference.

Results
The calculated sensitivity, specificity, accuracy, PPV, and NPV for US was 100%, 36.6%, 75.3%, 71.2%, and 100%, respectively. Statistical indices for qualitative DWI were 76.6%, 63.3%, 76.6%, 63.3%, and 71.4%, respectively (P value < 0.001). The calculated cut off value for ADC between infiltrated and non-infiltrated nodes was 0.95 × 10−3 mm2/s concluding statistical indices of 76.6%, 63.3%, 76.6%, 63.3%, and 71.4%, respectively (P value < 0.001).

Conclusion
Combining DW-MRI to conventional US improves diagnostic specificity and overall accuracy of preoperative axillary evaluation of patients with recently discovered breast cancer.
The Need for Patient-centered Education Among Patients Newly Diagnosed With a Pituitary Tumor
Authors: Donegan Diane , Gowan Tayler , Gruber Rachel , Cottingham Ann , Flanagan Mindy , Erickson Dana , Imperiale Thomas F 
Published: April 2021

Abstract

Objectives
Brain tumors, including pituitary adenomas (PA), cause anxiety and distress, with a high unmet need for information correlating with increased anxiety. Condition-specific education may alleviate anxiety. We explored patients’ experience around the diagnosis of a PA and piloted a patient education intervention to address peridiagnostic anxiety in adults diagnosed with PA.

Methods
Anxiety, patient satisfaction, patient knowledge, and need for information were measured prior to, immediately after, and 1 month following the appointment in this multimethods study. A phone interview to explore patient diagnostic and intervention experiences was analyzed using qualitative methods.

Results
A total of 17 patients participated in the study; 15 completed the interview. The baseline need for information was high. Disease-specific anxiety decreased, and patient knowledge and satisfaction increased significantly after the initial visit. Interview analysis identified 3 main themes: (1) the importance of communication; (2) the need for information; and (3) the impact of the diagnosis on patient experience.

Conclusions
For patients with newly diagnosed PA, the diagnostic experience was associated with high levels of anxiety. Patients expressed a need for information. Information delivery reduced anxiety and had a positive impact on patient satisfaction.

Practice Implications
The study findings suggest a need for a streamlined diagnostic process with readily accessible information.
Insulin-like Growth Factor 1 and Prolactin Levels in Chimpanzees (Pan troglodytes) Across the Lifespan
Authors: Ben-Shlomo Anat , McLachlan Sandra M , Hwe Jennifer , Aliesky Holly , Hasselschwert Dana , Mirocha James , Melmed Shlomo 
Published: April 2021

Abstract
As human and chimpanzee genomes show high homology for IGF1 and PRL, we analyzed the sera of 367 healthy chimpanzees obtained during routine physical examinations in a single colony and measured chimpanzee insulin-like growth factor (IGF)-1 and prolactin (PRL) levels across the lifespan using standard human immunoassays. Assuming chimpanzee IGF-1 levels peak during puberty as in humans, we randomly defined puberty as the age at which most IGF-1 levels were equal to or above the 90th percentile for each sex (males, ages ≥7.00 but &lt;9.20 years; females, ≥5.00 but &lt;8.00 years). IGF-1 levels steadily increased at a similar rate in juvenile males and females and peaked in puberty, strongly correlating with age, then slowly decreased faster in adult males than in adult females. As a group, males had a higher mean IGF-1 level than did females, but comparison by age category showed similar mean IGF-1 levels in males and females. PRL levels increased with age in females more than in males and levels were twice as high in females than in males. One pubertal male reported to have short stature had lower IGF-1 and weight compared with other males in the age group, confirming suspected growth hormone deficiency; a second male of normal height but low IGF-1 may have had delayed puberty. Overall, results show that differences in IGF-1 levels over the lifespan in this cohort of chimpanzees largely mimic those seen in humans, while patterns of PRL changes are less similar.
Economic Benefits of Changes in Active Transportation Behavior Associated with a New Urban Trail
Authors: Anderson Christopher E. , Izadi Maryam , Tian Guang , Gustat Jeanette 
Published: April 2021

ABSTRACT
Insufficient physical activity (PA) is a highly prevalent behavior and confers heightened risk of many chronic health conditions. Infrastructure for PA, including urban trails, represents a way of increasing PA at a population level. This study was conducted to determine the impact of an urban trail on PA, motor vehicle use, and to assess the benefit–expenditure ratio of mitigating the high public health burden of physical inactivity with bicycle and pedestrian trails. Intercept surveys were conducted, from December 2018 through March 2019, to assess PA, transportation mode, and travel distances among trail users before (2015) and after the trail opened in New Orleans, Louisiana. Statewide measures from 2015 to 2017 were used for comparison. Changes in PA and motor vehicle use were simulated based on survey data and monetized over a 30-yr period. Trail users who responded to the survey reported changes in PA (17.7-min weekly increase), nonactive transportation (3.1-mile weekly decrease), and motor vehicle ownership (6.5% decrease) from before the trail was opened to the present. Cumulative economic benefits (health care, mortality, and motor vehicle) exceeded trail-related expenditures in 2032, reaching a ratio of 1.51 in 2045. The urban trail in this study contributed to increased PA and reduced motor vehicle use and may reduce health care, mortality, and motor vehicle–related costs. Personal and social economic benefits from the increases in PA and reduction in motor vehicle ownership and ownership exceeded expenditures over the 30-yr simulation period. PA infrastructure can be a prudent investment of public resources.
Ethical, Regulatory and Market related aspects of Deploying Triple Artemisinin-Based Combination Therapies for Malaria treatment in Africa: A study protocol.
Authors: Tindana Paulina , de Haan Freek , Mokuolu Olugbenga Ayodeji , Guissou Rosemonde , Bolarinwa Oladimeji Akeem , Ouedraogo Jean Bosco , Tou Fatoumata , Boon Wouter P.C , Moors Ellen H.M , Dondorp Arjen M , Dhorda Mehul , Amaratunga Chanaki , Cheah Phaik Yeong 
Published: April 2021

Introduction: According to the World Malaria Report 2019, Africa accounts for 94% of the global malaria deaths. While malaria prevalence and mortality have declined over the years, recent reports suggest that these gains may stand the risk of being reversed if resistance to Artemisinin Combination Therapies (ACTs) spreads from Southeast Asia to Africa. Efforts are being made to develop new treatments that will address the looming threat of ACT resistance, including the development of triple artemisinin combination therapies (TACTs). The proposed study seeks to explore the views of stakeholders on the key ethical, regulatory and market-related issues that should be considered in the potential introduction of triple artemisinin combination therapies (TACTs) in Africa. Methods: The study employed qualitative research methods involving in-depth interviews and focus group discussions (FGDs) with stakeholders, who will be directly affected by the potential deployment of triple artemisinin combination treatments, as regulators, suppliers and end-users. Participants will be purposively selected and will include national regulatory authorities, national malaria control programs, clinicians, distributors and retailers as well as community members in selected districts in Burkina Faso and Nigeria. Discussion: The proposed study is unique in being one of the first studies that seeks to understand the ethical, social, regulatory and market position issues prior to the development of a prospective antimalarial medicine.