bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic status and infant nighttime sleep across the second year of life: The moderating role of infant attachment security
Authors: Bai Liu , Crosby Brian , Teti Douglas M. 
Published: December 2021

AbstractThis study examined socioeconomic status (SES) and attachment security as predictors of infant nighttime sleep during the second year. Participants included 128 mothers (86% White) with infants (48.4% boys). Data collection took place between April, 2009 and February, 2014. At 12, 18, and 24 months, infant sleep was assessed via actigraphy and daily diaries, and attachment with the Attachment Q‐Set. SES indicators included income‐to‐needs ratios and education. Lower SES predicted greater variability in sleep duration and later sleep timing only for less secure infants. Less secure attachment was associated with poorer sleep at both between‐ and within‐person levels, especially when infants were 12 months of age. Results emphasize the complex interactive effects of environmental and relational factors on infant sleep.
ClC‐c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila
Authors: Huang Jinping , Sheng Xiao , Zhuo Zhangpeng , Xiao Danqing , Wu Kun , Wan Gang , Chen Haiyang 
Published: December 2021

AbstractObjectivesAdult stem cells uphold a delicate balance between quiescent and active states, which is crucial for tissue homeostasis. Whereas many signalling pathways that regulate epithelial stem cells have been reported, many regulators remain unidentified.Materials and MethodsFlies were used to generate tissue‐specific gene knockdown and gene knockout. qRT‐PCR was used to assess the relative mRNA levels. Immunofluorescence was used to determine protein localization and expression patterns. Clonal analyses were used to observe the phenotype. RNA‐seq was used to screen downstream mechanisms.ResultsHere, we report a member of the chloride channel family, ClC‐c, which is specifically expressed in Drosophila intestinal stem/progenitor cells and regulates intestinal stem cell (ISC) proliferation under physiological conditions and upon tissue damage. Mechanistically, we found that the ISC loss induced by the depletion of ClC‐c in intestinal stem/progenitor cells is due to inhibition of the EGFR signalling pathway.ConclusionOur findings reveal an ISC‐specific function of ClC‐c in regulating stem cell maintenance and proliferation, thereby providing new insights into the functional links among the chloride channel family, ISC proliferation and tissue homeostasis.
Different functional feeding groups of mangrove soil molluscs invoke unique co‐occurrence patterns in response to a climate extreme
Authors: Chen Guogui , Gu Xuan , Liu Yi , Wang Wenqing , Wang Mao 
Published: December 2021

AbstractAimDue to differences in community functional traits and composition, the response of communities to environmental changes can be variable, and thus an understanding of the mechanisms underlying differential functional group responses is necessary. We investigated a mangrove soil mollusc community before (in 2007) and after (in 2008 and 2009) an extreme cold event (ECE) to determine the effects of the ECE on co‐occurrence patterns, spatiotemporal turnover and ecological processes in different functional groups (i.e. in‐faunal shelled deposit feeders [ISDFs] and hard‐bodied, mobile scavenger/predators [MS/Ps]).LocationSoutheast coasts of China.MethodWe used network analysis and null models to test the co‐occurrence patterns of the soil mollusc community. We used the analysis of distance and time decay to characterize the spatial turnover and temporal succession of the mollusc community based on presence/absence, relative abundance and biomass data. We performed random forest (RF), variation partitioning analysis (VPA) and Mantel tests to detect the effects of local environmental filtering and dispersal limitations on the soil mollusc community.ResultsWe found a decrease in species richness and biomass and an increase in abundance after an ECE, reflecting a significant change in mangrove soil mollusc communities. The network modularization, divergent succession and geographical differentiation of the ISDFs increased from 2008 to 2009, but environmental filtering and regional dispersal limitations decreased. The temporal trends of the network modules, geographical differentiation and dispersal limitations of MS/Ps followed a hump‐shaped pattern from 2008 to 2009, whereas the temporal trends of environmental filtering and temporal divergence exhibited an inverted hump‐shape pattern. The ECE changed the main environmental drivers of ISDFs and MS/Ps from water salinity to meteorology and vegetation factors.Main conclusionsMangrove soil mollusc communities in different functional groups invoked different spatiotemporal turnover models and ecological processes to shape unique co‐occurrence patterns in response to an ECE. We highlight the value of dividing different functional groups in developing predictive frameworks for a better understanding of community functional responses to global change.
Deification and sanctification in the dialogue between the Finnish Lutheran School and the Chinese Neo‐Confucian School
Authors: GAO Yuan 
Published: December 2021

AbstractThe ideal of becoming divine occupies a central position not only in Lutheran theology but also in Confucian traditional teachings. While expectations of these two traditions on the ideal of human life look different, it does not mean that they do not share any theoretical convergence. The present article explores an in‐depth look into the doctrine of deification (θεοποιεiν; theōsis) in the Finnish interpretation of Luther, where Tuomo Mannermaa (1937–2015) developed originally his theory in the Lutheran‐Orthodox dialogue, and forms a new landscape for building up a connection between the Finnish Lutheran School and Chinese Neo‐Confucianism in their accounts of deification (成神) and sanctification (成聖). The main objective of this study is to clarify the historical doctrine of theōsis in Luther's theology by analyzing the hermeneutic approach of divinization in the Finnish School and its contributions; and furthermore, to discover possibilities of dialogue between deification and sanctification and new approaches to them. Attending to distinctive features of the theology of hope in these two intellectual circles, this study untilizes the perspective of the deification of emotions, which would become a new approach in deepening the theory of deification in the Lutheran‐Confucian dialogue.
Family, healthcare professional, and societal preferences for the treatment of infantile spinal muscular atrophy: A discrete choice experiment
Authors: Carey Kate A. , Farrar Michelle A. , Kasparian Nadine A. , Street Deborah J. , De Abreu Lourenco Richard 
Published: December 2021

AimTo understand the factors that most influence decision‐making in the treatment of infantile spinal muscular atrophy (SMA).MethodA discrete choice experiment was conducted among parents of people with SMA (parents), healthcare professionals (HCPs), and members of the Australian general population (GenPop). Respondents were asked to accept/reject treatment for an infant newly diagnosed with SMA in eight hypothetical scenarios, characterized by different combinations of the attributes of the treatment offered. The results were analyzed using probability analysis.ResultsCompleted responses were provided from 1113 individuals (1024 GenPop, 21 parents, 68 HCPs). Respondents were more likely to accept treatments that improved functioning and mobility. Treatments with higher costs, invasive delivery, and risks of adverse events were accepted less often. Cost most affected treatment choices by HCPs and GenPop, while change in mobility and mode of administration were most influential for parents.InterpretationThese results highlight the importance of understanding value for money and clinical impact in affecting treatment choice, which are crucial for effective planning of healthcare and the successful implementation of treatment programmes for SMA.
What this paper adds

Spinal muscular atrophy (SMA) treatments with a higher chance of improving functioning and mobility are preferred by the general population, parents, and healthcare professionals.

Treatments with higher costs, invasive delivery, and risk of adverse events are less preferred.

Willingness to pay for SMA treatments increases with impact on functioning.
Potential of the fumigant ethanedinitrile to kill the pinewood nematode (Bursaphelenchus xylophilus) and other forest pathogens
Authors: Uzunovic Adnan , Kus Stacey , Hook Ashley , Leal Isabel 
Published: December 2021

AbstractA screening test was carried out using ethanedinitrile (EDN) as a candidate fumigant to replace methyl bromide for efficacy against a selection of forest pests, including the pinewood nematodes (Bursaphelenchus xylophilus) and four tree pathogens: Heterobasidion annosum, Geosmithia morbida, Phytophthora ramorum and Ceratocystis fagacearum. Two EDN concentrations were tested: 50 and 100 g/m3 at two different temperatures and six exposure times. In our tests, EDN was very efficient in killing pathogens in all test parameter combinations, including short exposure times and lower concentration, apart from C. fagacearum surviving short 1 h exposure and G. morbida surviving after 1 and 3 h of exposure. Pinewood nematodes in the small wood blocks were effectively killed at all test parameter combinations. In log sections where deeper nematode infestations were present, nematode survivors at 50 and 100 g/m3 after 1, 3, and 6 h exposure were observed. This suggests that the fumigant was not efficacious at lower exposure times, while penetrating log sections. Both 50 and 100 g/m3 dosages were effective after 24 h exposure, indicating that longer retention times are required to effectively kill pine wood nematodes in deeper wood sections. The lower temperature did not affect the efficacy of EDN. This indicates that EDN could successfully eradicate pinewood nematodes in logs over 24 h of exposure, or even less exposure time, at targeted concentrations.
The impact of donor type on resource utilisation and costs in allogeneic haematopoietic stem cell transplantation in the Netherlands
Authors: van Gorkom Gwendolyn , Van Elssen Catharina , Janssen Ian , Groothuis Siebren , Evers Silvia , Bos Gerard 
Published: December 2021

AbstractBackgroundAllogeneic haematopoietic stem cell transplantation (HSCT) is increasingly used, but this treatment is complex and costly. As clinical outcomes of HSCT with matched unrelated donor (MUD) and haploidentical donors are similar, costs could influence donor choice.MethodWe retrospectively compared resource utilisation and costs of HSCT using the three different donor types (matched related donor (MRD) (n = 32), haploidentical related (n = 30) and MUD (n = 60)) within the first year after transplantation. Costs were analysed through a bottom‐up method. Non‐parametric bootstrapping was applied to test for statistical differences in costs. Subgroup analyses were performed to identify predictors for costs.ResultsCost pre‐transplant for search and acquisition of the graft were significantly higher in MUD HSCT (€35 222) versus MRD and haploidentical HSCT (€15 356 and €16 097 respectively). The costs of haploidentical HSCT were the highest in the transplant phase. Main cost factors were inpatient days and medication. Overall, the costs for haploidentical and MUD HSCT were similar (€115 724 for MUD, €113 312 for haploidentical).ConclusionOur study suggests no difference in total transplantation costs between allogeneic HSCT using a MUD or a haploidentical donor. Since clinical outcomes seem similar as well, the choice of donor type might be based on availability, speed and logistics.
Co‐ordinated elevational diversity patterns for soil bacteria, fungi, and plants in alkaline soils of arid northwestern China
Authors: He Zhi‐Bin , Chen Long‐Fei , Zhao Wen‐Zhi , Liu Ji‐Liang , Song Ming‐Dan , Kong Jun‐Qia , Gao Yuan 
Published: December 2021

AbstractPlants often show remarkable elevational distribution patterns in arid‐montane ecosystems. However, it is not clear if soil microbes follow elevational diversity patterns, even though they represent the majority of biodiversity and drive varieties of ecological processes. Here, we conducted a survey of fungal and bacterial communities across an elevational gradient from 2350 to 3850 m in a typical mountainous grassland of arid northwestern China. Our results revealed co‐ordinated alpha and beta diversity patterns for soil microbes and plants along the elevational gradient, and the richness and Shannon diversity of bacteria, fungi, and plants exhibited a unimodal elevational pattern. The unimodal diversity pattern for soil microbes was further confirmed by the shifts in the relative abundance of dominant bacterial phyla (Actinobacteria, Firmicutes and Nitrospirae) and fungal phyla (Zygomycota) along the elevational gradient. Soil variables (soil pH, organic carbon, total nitrogen, available phosphorus, and nitrate nitrogen) explained the largest proportion of the variability in both bacterial and fungal communities, followed by plant (richness and Shannon diversity) and climatic (mean annual temperature and precipitation) variables. These environmental factors together explained a larger proportion of variability in bacterial communities (54.88%) than in fungal communities (24.15%). Our results strongly supported the existence of co‐ordinated elevational diversity patterns for soil microbes and plants in arid‐montane ecosystems, and highlighted that the importance of soil pH in microbial elevational patterns was also apparently in alkaline soils.Highlights
Soil bacteria and fungi follow elevational diversity patterns of plants.
Species richness and Shannon diversity index exhibited unimodal elevational patterns.
Soil, plant, and climatic factors are co‐responsible for microbial diversity.
These factors explained more variation in bacteria than that in fungi.
Microbial diversity is more vulnerable to precipitation than temperature.
Genomic survey of edible cockle (Cerastoderma edule) in the Northeast Atlantic: A baseline for sustainable management of its wild resources
Authors: Vera Manuel , Maroso Francesco , Wilmes Sophie B. , Hermida Miguel , Blanco Andrés , Fernández Carlos , Groves Emily , Malham Shelagh K. , Bouza Carmen ,   The Cockle’s Consortium, Robins Peter E. , Martínez Paulino 
Published: December 2021

AbstractKnowledge on correlations between environmental factors and genome divergence between populations of marine species is crucial for sustainable management of fisheries and wild populations. The edible cockle (Cerastoderma edule) is a marine bivalve distributed along the Northeast Atlantic coast of Europe and is an important resource from both commercial and ecological perspectives. We performed a population genomics screening using 2b‐RAD genotyping on 9309 SNPs localized in the cockle's genome on a sample of 536 specimens pertaining to 14 beds in the Northeast Atlantic Ocean to analyse the genetic structure with regard to environmental variables. Larval dispersal modelling considering species behaviour and interannual/interseasonal variation in ocean conditions was carried out as an essential background to which compare genetic information. Cockle populations in the Northeast Atlantic displayed low but significant geographical differentiation between populations (FST = 0.0240; p < 0.001), albeit not across generations. We identified 742 and 36 outlier SNPs related to divergent and balancing selection in all the geographical scenarios inspected, and sea temperature and salinity were the main environmental correlates suggested. Highly significant linkage disequilibrium was detected at specific genomic regions against the very low values observed across the whole genome. Two main genetic groups were identified, northwards and southwards of French Brittany. Larval dispersal modelling suggested a barrier for larval dispersal linked to the Ushant front that could explain these two genetic clusters. Further genetic subdivision was observed using outlier loci and considering larval advection. The northern group was divided into the Irish/Celtic Seas and the English Channel/North Sea, while the southern group was divided into three subgroups. This information represents the baseline for the management of cockles, designing conservation strategies, founding broodstock for depleted beds and producing suitable seed for aquaculture production.
Altitudinal diversity of aquatic plants in the Qinghai‐Tibet Plateau
Authors: Zhou Ya‐Dong , Xiao Ke‐Yan , Chen Si‐Chong , Liu Xing , Wang Qing‐Feng , Yan Xue 
Published: December 2021

Abstract

Altitudinal diversity of terrestrial plants has been widely studied, whereas little is known for the patterns of aquatic plants. Here, we used a standardised field dataset to quantify the altitudinal patterns in the diversity and structure of aquatic plant assemblages, as well as the relationships between diversity indices and environmental variables.

Large‐scale field investigations were carried out in 128 sites ranging from 2,280 to 5,020 m above sea level across the southern part of Qinghai‐Tibet Plateau, China. In total, 102 species of aquatic plants were recorded, belonging to 67 genera, 31 families. Five taxonomic, phylogenetic, and functional indices were calculated for each collection site. We firstly examined altitudinal patterns of these diversity indices, then quantified the variations of indices across water areas, water flow, and soil matrix, respectively. We also explored the relationships between diversity indices and environmental variables using redundancy and variance partitioning analysis, to detect the ecological variables that drove the diversity.

The results showed that taxonomic, phylogenetic, and functional diversity of aquatic plants decreased with increasing altitude. Net relatedness index of aquatic plants showed a hump pattern along the altitude gradient, with a peak around 3,800 m above sea level. There was no obvious trend in the net functional relatedness index of aquatic plants with altitude. Annual mean temperature was the most important variable associated with the taxonomic, phylogenetic, and functional diversity. Water area and water flow were significantly associated with functional structure, but not phylogenetic structure. Soil matrix also correlated with aquatic plant diversity.

A large‐scale altitudinal gradient can influence aquatic plant diversity. Environmental filtering and niche convergence might have played dominant roles in the increasing and decreasing stages of phylogenetic structure of aquatic plant assemblages, respectively, along the altitudinal gradient. Phylogenetic and functional structure of aquatic plant assemblages showed different patterns along the altitudinal gradient, and the environmental variables better explained the change of functional structure than did the phylogenetic variables.

This is the first comprehensive study on the species, phylogeny, and function of aquatic plant assemblages along a large‐scale altitudinal gradient. We found an altitudinal decline in the diversity of aquatic plants and different patterns in the phylogenetic and functional structures of aquatic plant assemblages. These findings indicate that functional traits have high phenotypic plasticity and are more affected by environments than phylogenetic relationships which are mainly shaped by evolutionary processes.
Nature‐based framework for sustainable afforestation in global drylands under changing climate
Authors: Liu Hongyan , Xu Chongyang , Allen Craig D. , Hartmann Henrik , Wei Xiaohua , Yakir Dan , Wu Xiuchen , Yu Pengtao 
Published: December 2021

AbstractDrylands cover more than 40% of Earth's land surface and occur at the margin of forest distributions due to the limited availability of water for tree growth. Recent elevated temperature and low precipitation have driven greater forest declines and pulses of tree mortality on dryland sites compared to humid sites, particularly in temperate Eurasia and North America. Afforestation of dryland areas has been widely implemented and is expected to increase in many drylands globally to enhance carbon sequestration and benefits to the human environment, but the interplay of sometimes conflicting afforestation outcomes has not been formally evaluated yet. Most previous studies point to conflicts between additional forest area and water consumption, in particular water yield and soil conservation/desalinization in drylands, but were generally confined to local and regional scales. Our global synthesis demonstrates that additional tree cover can amplify water consumption through a nonlinear increase in evapotranspiration—depending on tree species, age, and structure—which will be further intensified by future climate change. In this review we identify substantial knowledge gaps in addressing the dryland afforestation dilemma, where there are trade‐offs with planted forests between increased availability of some resources and benefits to human habitats versus the depletion of other resources that are required for sustainable development of drylands. Here we propose a method of addressing comprehensive vegetation carrying capacity, based on regulating the distribution and structure of forest plantations to better deal with these trade‐offs in forest multifunctionality. We also recommend new priority research topics for dryland afforestation, including: responses and feedbacks of dryland forests to climate change; shifts in the ratio of ecosystem ET to tree cover; assessing the role of scale of afforestation in influencing the trade‐offs of dryland afforestation; and comprehensive modeling of the multifunctionality of dryland forests, including both ecophysiological and socioeconomic aspects, under a changing climate.
Driving the digital value network: Economic geographies of global platform capitalism
Authors: Howson Kelle , Ferrari Fabian , Ustek‐Spilda Funda , Salem Nancy , Johnston Hannah , Katta Srujana , Heeks Richard , Graham Mark 
Published: December 2021

AbstractThis paper applies insights from global value chains (GVC)/global production networks (GPN) frameworks to explore the economic geographies brought into being by digital labour platforms. In particular, these perspectives facilitate analyses of power imbalances and value extraction across territories—an under‐theorized aspect within platform studies. We theorize this dynamic by introducing the descriptor ‘digital value network’ (DVN): a digitally mediated nexus of platform operations that produce and distribute value between territories, on the basis of labour transactions. Empirically, we draw on a multi‐year action research project, assessing the operations of platforms and the experiences of platform workers in 54 countries. Our analysis highlights that platforms as lead firms extend GVC/GPN logics of coordination and drivenness in DVN to (i) optimize production capabilities while externalizing ownership and costs, (ii) accumulate both monetary and non‐monetary forms of value, and (iii) concentrate power at the global scale in both existing and new sectors.