bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric assessment of changes in the alveolar ridge dimension following guided bone regeneration using a combination freeze‐dried bone allograft with collagen membrane or novel resorbable scaffold: A prospective two‐center clinical trial
Authors: Dowlatshahi Sahar , Chen Chia‐Yu , Zigdon‐Giladi Hadar , Horwitz Jacob , Ahn Chiho , Kim David M. , Machtei Eli E. 
Published: July 2021

AbstractBackgroundThe aim of this study was to examine osseous changes following lateral bone augmentation using a novel scaffold (OV) alone and compare it to combination therapy using freeze‐dried bone allograft (FDBA) and resorbable collagen membrane (FDBA/CM).MethodsThirty patients completed this 9‐months prospective two‐center cohort clinical trial. Before surgery and 9‐months re‐entry, linear measurements were performed, and impressions taken. Cone‐beam computed tomography (CBCT) were done at baseline and 9 months. DICOM slice data were converted into volumetric images using 3D Slicer. Following 3D volumetric image construction, pre‐ and post‐op Standard Triangle Language files were superimposed and volumetric data were extracted for a 10‐mm region of interest. Linear measurements were compared similarly.ResultsBaseline clinical parameters were similar in both groups (4.22 and 4.53 mm for OV and FDBA/CM at ‐2 mm, respectively). Following treatment, vertical distance from the stent had changed minimally (‐0.36 and ‐0.12 mm, respectively). Similarly, lateral bone gain ranged from 0 to 0.4 mm, for both groups. To the contrary, the CBCT measurements showed a significantly greater increase in horizontal width in the control at ‐2 mm (0.95 ± 0.2 mm) compared with ‐0.62 mm for the OV (P = 0.000). Similar changes were observed at ‐5 mm (0.63 and ‐0.41 mm, respectively, P = 0.01). Sites volume had increased from 266 ± 149 mm3 to 360 ± 138 mm3 (P = 0.001) for FDBA/CM with negligible changes for OV (from 334 to 335 mm3, P = 0.952). these between‐group changes being statistically significant (P = 0.023).ConclusionFDBA/CM yielded better albeit moderate increase in the volume of the edentulous ridge, while OV scaffolds failed to produce similar results.
Bayesian meta‐analysis usingSAS PROC BGLIMM
Authors: Rott Kollin W. , Lin Lifeng , Hodges James S. , Siegel Lianne , Shi Amy , Chen Yong , Chu Haitao 
Published: July 2021

AbstractMeta‐analysis is commonly used to compare two treatments. Network meta‐analysis (NMA) is a powerful extension for comparing and contrasting multiple treatments simultaneously in a systematic review of multiple clinical trials. Although the practical utility of meta‐analysis is apparent, it is not always straightforward to implement, especially for those interested in a Bayesian approach. This paper demonstrates that the recently‐developed SAS procedure BGLIMM provides an intuitive and computationally efficient means for conducting Bayesian meta‐analysis in SAS, using a worked example of a smoking cessation NMA data set. BGLIMM gives practitioners an effective and simple way to implement Bayesian meta‐analysis (pairwise and network, either contrast‐based or arm‐based) without requiring significant background in coding or statistical modeling. Those familiar with generalized linear mixed models, and especially the SAS procedure GLIMMIX, will find this tutorial a useful introduction to Bayesian meta‐analysis in SAS.
Power of the collective: A review of multimodal internet‐based surgical education resources in the 21st century
Authors: Barmettler Gabi , Adnan Sakib , Malcolm Threshia S. N. , Terhune Kyla , Joshi Amit R.T. 
Published: July 2021

AbstractElectronic resources have changed surgical education in the 21st century. Resources spanning from digital textbooks to multiple choice question banks, online society meetings, and social media can facilitate surgical education. The COVID pandemic drastically changed the paradigm for education. The ramifications of Zoom lectures and online surgical society meetings will last into the future. Educators and learners can be empowered by the many available electronic resources to enhance surgical training and education.
Tele‐education assisted mentorship in surgery (TEAMS)
Authors: Williams Taylor P. , Klimberg Vicki , Perez Alexander 
Published: July 2021

AbstractTele‐education assisted mentorship in surgery (TEAMS) is a novel methodology for surgical skills training with remote, hands‐on, high‐fidelity, and low‐cost simulation‐based education and one‐to‐one mentorship with longitudinal assessments. We review the background, methodology, and our experience with implementing TEAMS as an adjunct to traditional methods of surgical education and mentorship.
Telesimulation for remote simulation and assessment
Authors: Roach Eileen , Okrainec Allan 
Published: July 2021

AbstractTelesimulation (TS), the process of using the internet to link educators and trainees at locations remote from one another, harnesses the powers of technology to enable access to high‐quality simulation‐based education and assessment to learners across the globe. From its first uses in the teaching and assessment of laparoscopic skills to more recent interpretations during the current pandemic, TS has shown promise in helping educators to address pressing dilemmas in medical education.
Application of technology to educational needs in surgery
Authors: Beqari Jorind , Seymour Neal E. 
Published: July 2021

AbstractInnovations in surgical education follow advancing clinical technology. New surgical methods have prompted demand for systematic methods to leverage computing power and internet tools to achieve proficiency‐based training goals. Virtual reality, high‐fidelity patient simulation, web‐based resources to facilitate performance assessment, and telementoring have become mainstream practices, although patient outcomes benefits are not well studied. Remote virtual meeting and mentoring have had transformative effects on resident experiences, the full effects of which remain to be seen.
Team training and surgical crisis management
Authors: Tsuda Shawn , Olasky Jaisa , Jones Daniel B. 
Published: July 2021

AbstractTeam training and crisis management derive their roots from fundamental learning theory and the culture of safety that burgeoned forth from the industrial revolution through the rise of nuclear energy and aviation. The integral nature of telemedicine to many simulation‐based activities, whether to bridge distances out of convenience or necessity, continues to be a common theme moving into the next era of surgical safety as newer, more robust technologies become available.
Educational value of surgical telementoring
Authors: A. Butt Khayam , Augestad Knut Magne 
Published: July 2021

AbstractEducating surgeons is a time‐consuming process. In addition to theoretical knowledge, the practical tasks of surgical procedures must be mastered. Translation of such knowledge from mentor to mentee may be efficiently done by surgical telementoring (ST). This is a review on surgical telementoring. Recent technological advances have made this tool in surgical education more available and applicable but future applications of ST have to be wisely guided by high‐quality trials.
Optimal heating rate in constant pressure and constant flow gas chromatography
Authors: Merrick Mark , Blumberg Leonid M. 
Published: July 2021

AbstractOptimal heating rate is the one resulting in the shortest analysis time for achieving a required separation performance of a column. The previously recommended default heating rate (RT,Def) was optimal for temperature‐programmed gas chromatography analyses in constant pressure mode. It has been shown herein that the same recommendation can be extended to constant flow mode with fixed heating rate (RT). The numerical value of RT,Def has been herein rescaled from previous (10°C per void time) where tM was measured at 50°C, to with tM measured at 150°C—a round number in the middle of the gas chromatography temperature range, chosen as a reference temperature for numerical values of all temperature‐dependent gas chromatography parameters.It has been experimentally found based on theory developed herein that is optimal for columns with ( is dimensionless film thickness, d and df are the column internal diameter and film thickness, respectively) in constant pressure mode and constant flow mode with fixed RT. Theory shows that, for arbitrary φ, . The theory also shows that the fixed RT is optimal for constant pressure mode. In constant flow mode, however, the optimal RT should gradually increase with increasing temperature (T). The optimal theoretical curves RT(T), different for different flow rates, were found. However, only the optimization of the fixed RT was experimentally evaluated due to limited capability of existing gas chromatography instrumentation and resources. It has been shown that the separation‐time tradeoff in constant pressure mode is slightly better than that in constant flow mode. The experimental data are compiled in the Supporting information.
Vulnerability to COVID‐19–Related Disability: The Impact of Posttraumatic Stress Symptoms on Psychosocial Impairment During the Pandemic
Authors: Morabito Danielle M. , Bedford Carter E. , Woller Savannah , Schmidt Norman B. 
Published: July 2021

AbstractAs a result of the COVID–19 pandemic, many individuals have experienced disruptions in social, occupational, and daily life activities. Individuals with mental health difficulties, particularly those with elevated posttraumatic stress symptoms (PTSS), may be especially vulnerable to increased impairment as a result of COVID–19. Additionally, demographic factors, such as age, gender, and race/ethnicity, may impact individual difficulties related to the pandemic. The current study examined the concurrent and prospective associations between posttraumatic stress disorder (PTSD) symptoms, broader anxiety and depression symptoms, and COVID–19–related disability. Participants recruited through Amazon's Mechanical Turk (N = 136) completed questionnaire batteries approximately 1 month apart during the COVID–19 pandemic (i.e., Wave 1 and Wave 2). The results indicated that PTSD, anxiety, and depressive symptoms were all associated with increased COVID–19–related disability across assessment points, rs = .44–.68. PTSD symptoms, specifically negative alterations in cognition and mood, significantly predicted COVID–19–related disability after accounting for anxiety and depressive symptoms as well as demographic factors, βs = .31–.38. Overall, these findings suggest that individuals experiencing elevated PTSS are particularly vulnerable to increased functional impairment as a result of COVID–19 and suggest a need for additional outreach and clinical care among individuals with elevated PTSD symptoms during the pandemic.
Hsa‐circ_0000064 accelerates the malignant progression of gastric cancer via spongingmicroRNA‐621
Authors: Hare Ayiguli , Zeng Min , Rehemutula Aizimaiti , Su Shi‐Kun , Wang Hai‐Feng 
Published: July 2021

AbstractGastric cancer (GC) is one of the most common digestive system tumors in the world. Many circular RNAs (circRNAs) are involved in the progression of GC. The purpose of this study was to delve into the expression characteristics and biological functions of circ_0000064 in GC, and further study its mechanisms. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was performed to detect circ_0000064 expression in 61 GC tissues and cell lines. Circ_0000064 knockdown was successfully modeled with siRNA. The effects of circ_0000064 on the biological functions of GC cells were analyzed by CCK‐8, BrdU, and Transwell assays. Bioinformatics and dual‐luciferase reporter gene assay were adopted to explore the relations between circ_0000064 and microRNA‐621 (miR‐621). Western blot was used to examine the regulatory function of circ_0000064 and miR‐621 on SYF2 pre‐mRNA splicing factor 2. Cric_0000064 expression was elevated in GC tissues and cell lines. Knocking down cric_0000064 could inhibit the viability, migration, and invasion of GC cells. Dual‐luciferase reporter gene assay showed that miR‐621 could bind circ_0000064 and SYF2 3'UTR; in addition, miR‐621 overexpression or SYF2 knockdown could partially weaken the cancer‐promoting effect of circ_0000064 on GC cells. Circ_0000064 expression was negatively correlated with miR‐621 expression in GC tissues while positively with SYF2 expression. Circ_0000064 can participate in the GC progression via modulating miR‐621/SYF2 axis. This implies that circ_0000064 may be a new diagnosed biomarker or a new therapeutic target of GC.
Flexible fiber‐based CO2 laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery
Authors: Rosenthal Matthew , Baser Raymond E. , Migliacci Jocelyn , Boyle Jay O. , Morris Luc G. T. , Cohen Marc A. , Singh Bhuvanesh , Shah Jatin P. , Wong Richard J. , Patel Snehal , Ganly Ian 
Published: July 2021

AbstractImportanceThis study reports the impact of laser surgery on quality of life in patients with oral cavity lesions.ObjectiveTo compare postoperative pain and quality of life in patients treated with flexible fiberoptic CO2 laser vs electrocautery in patients with oral cavity precancerous lesions and early stage cancers.DesignRandomized controlled trial.SettingSingle center.ParticipantsPatients with premalignant oral cavity lesions and early stage oral cancer.InterventionPatients were randomized to have surgical resection using either flexible fiber carbon dioxide laser (Laser) or electrocautery (EC). The patients were then followed over a period of 28 days to assess for outcomes including pain, quality of life, performance status, return to work, and return to diet. Quality of life was measured by the University of Washington Quality of Life (UWQOL) questionnaire and the performance status score (PSS).Main outcome measureThe primary endpoint for this study was the numerical pain rating on postoperative day (POD) 7.ResultsSixty‐two patients were randomized (32 laser and 30 electrocautery). Lesions excised were carcinoma in 30(48%), dysplasia in 31(50%) and benign in 1(2%). There was no difference in the location of lesion, size of lesion, defect size, type of closure, resection time, and blood loss between Laser and EC arms. Patients who had Laser had less pain compared to EC (mean pain score on POD 7 L = 2.84 vs EC = 3.83, P = 0.11). better UW QOL scores and PSS scores, quicker return to normal diet (median days L = 26.0 vs EC = 28.5, P = 0.17) and faster return to work (median days L = 13.0 vs EC = 16.5, P = 0.14). However, these results were not statistically significant.ConclusionThere was a trend for patients treated with laser to have less pain and better quality of life scores but these result were not statistically significant. Based on the actual observed difference, a large multicenter RCT with 90 patients in each arm is required to determine the clinical relevance of our results.
Facile Deposition of Silver Nanoparticles on Photonic Cellulose Nanocrystals Films: A Study on Solvent Stability and Post Antibacterial Activity
Authors: Hanif Zahid , Khan Zeeshan Ahmad , Shin Dongho , Choi Dongwhi , Park Sung Jea 
Published: July 2021

AbstractCellulose nanocrystals (CNCs) incorporated with silver nanoparticles (AgNPs) photonic films have drawn considerable attention due to their plasmonic chiroptical activity. However, the exploitation of some fundamental properties for practical use such as the affinity analysis of metal nanoparticles attached to the surface of photonic films according to the solvent compatibility and antibacterial activity under physical conditions has yet not been studied. Hence, a facile process of in situ deposition of AgNPs into the chiral structure of CNC films is proposed. CNC photonic films, cross‐linked by glutaraldehyde are prepared. This interaction generated the solvents‐stable photonic film with a considerable amount of unreacted aldehyde functional groups that facilitates the reduction of Ag salt to AgNPs. The formed AgNPs in the photonic films show excellent stability over immersion in various polar and non‐polar solvents. The post‐solvent treated photonic films display excellent contact‐based antibacterial behavior against gram‐negative Escherichia coli.
Controllable Power‐Law Distribution in Free‐Radical Vinyl/Divinyl Copolymerization by Using a Continuous Stirred Tank Reactor
Authors: Tobita Hidetaka 
Published: July 2021

AbstractIt has been believed that the power‐law molecular weight distribution is formed at the gel point, and the power exponent falls in a category of universality in critical phenomena, and therefore, it cannot be changed. It is found that the power‐law weight fraction distribution W(P) ∝ P−α, capable of controlling the exponent α, can be synthesized by using a continuous stirred tank reactor (CSTR). The exponent is governed by a single non‐dimensional parameter, ξ that is equivalent to the Damköhler number, representing the ratio of timescales between the mean residence time and the crosslinking reaction. For small ξ’s, the non‐critical transition of the weight‐average molecular weight to infinity is observed, and the exponent approaches α = 2. For large ξ’s, the system shows similar behavior to that in a closed system and the exponent is the same as for the batch polymerization, with α = 1.5. At the gel point, the product of the average crosslinking density and the weight‐average primary chain length satisfies the relationship, . The crosslinking density of the gel molecule at the gel point is found to be .
Financial performance drivers in BRICS healthcare companies: Locally estimated scatterplot smoothing partial utility functions
Authors: Wanke Peter , Azad Md. Abul Kalam , Tan Yong , Pimenta Roberto 
Published: July 2021

AbstractThe Healthcare sector is increasing in importance and relative size in BRICS countries (Brazil, Russia, India, China, South Africa). Despite BRICS relevance, the financial performance of their healthcare companies has been scarcely studied. This research fills this literature gap not only by focusing on the impacts of such diverse business environments on the financial performance of healthcare providers but also by proposing a novel approach to estimate an overall financial performance index based on weighted additive utility functions given a set of financial performance criteria. Precisely, bootstrapped Singular Value Decomposition is the cornerstone for identifying an orthogonal base of rotated financial performance criteria, upon which partial utility functions (PUFs) are estimated using locally estimated scatterplot smoothing (LOESS) polynomial regression. A compromise weighting scheme between singular values and quadratic programming results for minimal covariance and joint entropy matrices of residuals was used for summing up the PUFs. Results indicate that the values of financial performance range between 0.7 and 0.85. We further find that current assets, level of debt and liability, the company's Tobin Q are related to the financial performance. Besides, business freedom, government integrity, tax burden, monetary freedom and government spending are also the determinants of financial performance.
Inhibitory Effect of Garcinol on Obesity‐Exacerbated, Colitis‐Mediated Colon Carcinogenesis
Authors: Lee Pei‐Sheng , Nagabhushanam Kalyanam , Ho Chi‐Tang , Pan Min‐Hsiung 
Published: July 2021

ScopeEpidemiological studies show a consistent and compelling association between the risk of colorectal cancer development and obesity, but its mechanisms remain poorly understood. Evidence is mounting that colorectal cancer can be prevented by nutritional supplements, such as phytochemicals. Garcinol, a polyisoprenylated benzophenone derivative, is widely present in Garcinia plants. This study investigates the potential role of garcinol supplementation in ameliorating obesity‐induced colon cancer development.Methods and ResultsAn animal model to investigate the effect of high‐fat‐diet (HFD)‐induced obesity on promoting colitis‐associated colon cancer (AOM (azoxymethane)/DSS (dextran sodium sulfate)‐induced) is designed. The results show that HFD can promote colitis‐associated colon cancer as compared to an AOM/DSS group without the intervention of obesity, and supplementing with 0.05% garcinol in the diet can significantly ameliorate obesity‐promoted colon carcinogenesis. The results also reveals that the microbiota composition of each group is significantly different and clustered. The most representative genera are Alistipes, Romboutsia, and Ruminococcus. The RNA‐sequencing results show that the administration of garcinol can regulate genes and improve obesity‐promoting colitis‐associated colon carcinogenesis.ConclusionThe study results suggest that garcinol can prevent obesity‐promoted colorectal cancer, and these findings provide important niches for the future development of garcinol as functional foods or adjuvant therapeutic agents.
Deep‐learning‐based nuclear power plant fault detection using remote light‐emitting diode array data transmission
Authors: Choi Yourak , Bae Ji‐Hoon , Yeo Doyeob , Cho Dongyun , Lee Jaecheol , Lee Jeonghan , Kwon Ohseok 
Published: July 2021

AbstractThis paper proposes a deep‐learning‐based wireless sensor system that uses an embedded two‐dimensional (2D) light‐emitting diode (LED) array to display measured sensor data and remote data transmission to detect nuclear power plant (NPP) equipment defects. The frequent use of electromagnetic waves often interferes with the operation of NPP. Therefore, we devised a wireless image transmission network using a 2D LED array panel that includes a sensor module and a camera to capture LED array images. Based on the experimental results, the proposed method adopting deep‐learning‐based LED array data extraction produces reliable digital data restoration performance in terms of classification accuracy, even in a complex noise environment.
Asymmetric meander line slot‐based X‐band leaky wave antenna
Authors: Kumar Awanish , Reddy G. Shrikanth , Padhi Jyoti B. , Narayan Shiv 
Published: July 2021

AbstractThis article presents broadband, high gain, and highly efficient, leaky wave antenna for X‐band applications. The proposed leaky wave antenna consists of periodic unit cells created by a combination of modified asymmetric meander line slots and an array of metallic via. The proposed unit cell configuration work as a composite left hand‐right hand leaky wave transmission line and it is characterized using dispersion analysis. The simulated and measurement results indicate that the proposed antenna offers a wide bandwidth of 52.94% (*with stop band of 2.1%) and a large beam scanning range from −59° to 70° with a maximum measured gain of 13.1 dBi.