bluuebunny/crossref_metadata_2025_split huggingface dataset:
MultiVI: deep generative model for the integration of multi-modal data
Authors: Ashuach Tal , Gabitto Mariano I. , Jordan Michael I. , Yosef Nir 
Published: August 2021

AbstractJointly profiling the transcriptional and chromatin accessibility landscapes of single-cells is a powerful technique to characterize cellular populations. Here we present MultiVI, a probabilistic model to analyze such multiomic data and integrate it with single modality datasets. MultiVI creates a joint representation that accurately reflects both chromatin and transcriptional properties of the cells even when one modality is missing. It also imputes missing data, corrects for batch effects and is available in the scvi-tools framework: https://docs.scvi-tools.org/.
Evolutionary history of mammalian UDP-glucuronosyltransferase (UGT)1 and UGT2 families: the emergence of UGT2B subfamily in eutherians after the diversification of flowering plants
Authors: Kawai Yusuke K. , Sano Kasumi , Ikenaka Yoshinori , Nakayama Shouta M.M. , Kondo Mitsuki , Kubota Akira , Ishizuka Mayumi 
Published: August 2021

AbstractThe UDP-glucuronosyltransferase (UGT) gene family is responsible for the transfer of glucuronic acid to exogenous and endogenous chemicals. Based on the highly diversified number of genes, the mammalian UGT1A and UGT2B subfamily genes are believed to be involved in the conjugation reactions of xenobiotic metabolism. However, it is speculated that the UGT2 family genes are not involved in the xenobiotic metabolism of avian species due to the less diverse number of genes. In this study, we aimed to investigate the evolutionary history of mammalian UGT1 and UGT2 family genes and determine when the diversification ofUGT2Bgenes occurred. We also attempted to identify the main factors responsible for the diversification ofUGTgenes and the effect of the selection pressure on the structure of the UGT isozymes. By examining the genomic information and feeding habits of 67 species representing each mammalian family, we discovered that theUGT2Bgenes emerged in the Eutheria on or after Cretaceous period and that their number were higher in plant-eating mammals (herbivore or omnivore) than in carnivorous mammals. We also found that theUGT2Bgenes in some herbivorous mammals underwent positive selection. In contrast, the diversity of the UGT1 family genes was inherited from the common ancestor of birds and mammals. Furthermore, by predicting 3D structure of UGT enzymes, estimating selection pressure on amino acid sites, and performing molecular dynamics simulations, we showed that UGT2B and some UGT2A isozymes, which have increasing gene numbers in each mammalian species, have in common that a portion of the α-helix loosens to form a hinge-like structure, that the amino acid site at which the α-helix loosens is under positive selection, and that the α-helix loosening increases the fluctuations of the UGT2B proteins. Thus, our findings suggest that the emergence of angiosperms (flowering plants) and the occurrence of “animal–plant warfare” influenced the evolution of this gene family involved in the xenobiotic metabolism of eutherians. Furthermore, future research investigating the marsupials and birds that do not possessUGT2Bgenes is required to elucidate the mechanisms underlying the metabolism of chemical substances in these species.
Long-term translocation explains population genetic structure of a recreationally fished iconic species in Japan: Combining current knowledge with reanalysis
Authors: Kitada Shuichi 
Published: August 2021

AbstractAyu (Plecoglossus altivelis altivelis) is an important freshwater fisheries resource and popular recreational fishing species in Japan, lives for only one year, and has a single breeding season. To supplement increased recreational fishing demand for this species, huge numbers of wild-born landlocked juveniles have been translocated from Lake Biwa into most Japanese rivers for more than 100 generations. Hatchery-reared juveniles born from captive-reared parents for more than 30 generations have also been extensively released. Previous studies have reported that landlocked and amphidromous forms of Ayu easily hybridise, but survival of landlocked larvae could be very low in seawater, leading to a general consensus among scientists, hatchery managers, and commercial and recreational fishers that the reproductive success of landlocked Ayu is very low, or even 0 in translocated rivers. Despite this, limited information exists regarding the reproductive success of landlocked Ayu in translocated rivers, and no study has evaluated the effects of translocation on population structure. Demonstrating that hybridisation occurs between the two forms is central to future management and conservation of this specie. To address this issue, a comprehensive literature search was undertaken, and three published genetic data sets are analysed. Analyses provide strong evidence for very high gene flow between populations, but population structure has been retained in several regions, and several populations are nested. Allele frequencies are similar in amphidromous and landlocked forms. Genetic diversity is homogeneous in amphidromous populations. Bayesian admixture analysis infers widespread introgression in Japanese rivers, with a mean introgression proportion of 24 ± 8%. Maximum likelihood admixture graphs detect two migration events from Lake Biwa to anadromous populations. Analyses consistently indicate that hybridisation between translocated landlocked juveniles and native amphidromous Ayu occurs throughout Japanese rivers.
Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance
Authors: Schlautmann Lena P. , Boehm Volker , Lackmann Jan-Wilm , Altmüller Janine , Dieterich Christoph , Gehring Niels H. 
Published: August 2021

AbstractThe exon junction complex (EJC) is an RNA-binding multi-protein complex with critical functions in post-transcriptional gene regulation. It is deposited on the mRNA during splicing and regulates diverse processes including pre-mRNA splicing, mRNA export, mRNA translation, and nonsense-mediated mRNA decay (NMD) via various interacting peripheral proteins. The EJC-binding protein RNPS1 might serve two functions: it suppresses mis-splicing of cryptic splice sites and activates NMD in the cytoplasm. When analyzing the transcriptome-wide effects of EJC and RNPS1 knockdowns in different human cell lines, we find no evidence for RNPS1 being a globally essential NMD factor. However, various aberrant splicing events strongly suggest that the main function of RNPS1 is splicing regulation. Rescue analyses revealed that about half of these RNPS1-dependent splicing events was fully or partially rescued by the expression of the isolated RRM domain of RNPS1, whereas other splicing events are regulated by its C-terminal domain. We identified many splicing-regulatory factors, including SR proteins and U1 snRNP components, that specifically interact with the C-terminus or with the RRM of RNPS1. Thus, RNPS1 emerges as a multifunctional splicing regulator that promotes correct and efficient splicing of different vulnerable splicing events via the formation of diverse splicing-promoting complexes.
Energetic, exergetic, exergoeconomic, environmental (4E) and sustainability performances of an unmanned aerial vehicle micro turbojet engine
Authors: Balli Ozgur , Dalkıran Alper , Karakoç Tahir Hikmet 
Published: August 2021

PurposeThis study aims to investigate the aviation, energetic, exergetic, environmental, sustainability and exergoeconomic performances of a micro turbojet engine used in unmanned aerial vehicles at four different modes.Design/methodology/approachThe engine data were collected from engine test cell. The engine performance calculations were performed for four different operation modes.FindingsAccording to the results, maximum energy and exergy efficiency were acquired as 19.19% and 18.079% at Mode 4. Total cost rate was calculated as 6.757 $/h at Mode-1, which varied to 10.131 $/h at Mode-4. Exergy cost of engine power was observed as 0.249 $/MJ at Mode-1, which decreased to 0.088 $/MJ at Mode-4 after a careful exergoeconomic analysis.Originality/valueThe novelty of this work is the capability to serve as a guide for similar systems with a detailed approach in the thermodynamic, thermoeconomic and environmental assessments by prioritizing efficiency, fuel consumption and cost formation. This investigation intends to establish a design of the opportunities and benefits that the thermodynamic approach provides to turbojet engine systems.
Health status of people with autism spectrum disorder
Authors: Koceski Antonio , Trajkovski Vladimir 
Published: August 2021

Purpose
The aim of this study is to determine what changes occur in the health status of people with autism spectrum disorder (ASD) compared to neurotypical controls.

Design/methodology/approach
The authors performed a comparative analysis of data collected from 72 subjects with ASD and 75 neurotypical controls aged 3–24 years using the Rochester Health Status Survey IV (RHSS-IV). A structured individual interview was conducted to compare the health status of subjects in Macedonia.

Findings
A majority of people with ASD take vitamins, supplements and use recommended drug therapies compared to the neurotypical population and experience a larger number of side effects (p = 0.000). Compared to people with neurotypical development, children with ASD have a higher prevalence of oral ulcers (31.9% vs 17.3%; p = 0.039), changes in neurological health status – epilepsy (19.4% vs 2.7%; p = 0.001) and ADD/ADHD (only persons with ASD-19.4%; p = 0.000); respiratory diseases – angina (30.5% vs 8%; p = 0.000), rhinitis and/or sinusitis (40.3% vs 17.3%; p = 0.02); changes in the gastrointestinal system – constipation (31.9% vs 10.6%; p = 0.02), intestinal inflammation (19.4% vs 8%; p = 0.043), permeable intestines (only persons with ASD – 13.9%; p = 0.000) and the presence of the fungus Candida albicans (19.4% vs 4%; p = 0.043); psychiatric disorders – sleep problems (only in people with ASD – 18%; p = 0.000) and tics (6.9% vs 2.6%; p = 0.25) and skin diseases – eczema/allergic skin rash (36.1% vs 18.7%; p = 0.02).

Originality/value
Many children with ASD have health problems. These findings support and complement the professional literature on their mutual causality.
Impacts of big data analytics management capabilities and supply chain integration on global sourcing: a survey on firm performance
Authors: Razaghi Shokouh , Shokouhyar Sajjad 
Published: August 2021

Purpose
This study aims to show that management with big data analytics capability can achieve more advantages of the global sourcing process. Furthermore, this study using its conceptual attitude model aims to show that big data analytics management capability leads to an increase in firm performance by the mediating role of integration.

Design/methodology/approach
Using an online questionnaire, 158 managers from 13 Iranian companies taking advantage of the global sourcing process were surveyed. The validity of the hypotheses was evaluated using partial least squares based on structural equation modeling (PLS method).

Findings
The results of the study showed that big data analytics management capability has a positive impact on global sourcing and firm performance directly, and by the mediating role of integration.

Originality/value
Previous studies have carefully addressed the role of big data and big data analytics in firms. However, this is among a few studies addressing the role of big data analytics capability, especially management capability, in improving firms’ performance. The results of this study shed light on the fact that how global sourcing takes the best advantage of big data analytics management capability for better accomplishment of organizations’ duties. The results of this study also disclose how big data analytics management capability helps organizations with their performance and bring benefits to their units.
Challenges and prospects of linked data technology: a qualitative study of Pakistani LIS professionals’ insights
Authors: Warraich Nosheen Fatima , Rasool Tayayba , Rorissa Abebe 
Published: August 2021

PurposeThis study aims to explore the perceived challenges and prospects of linked data (LD) technology along with the skills required among library professionals to take LD initiatives in Pakistani libraries.Design/methodology/approachA qualitative research design with the phenomenology approach was used to meet the objectives of the study. Data was collected through in-depth interviews from 18 senior libraries and information science (LIS) professionals who were well versed with technology. This sample consisted of informants who provided rich and privileged information about the topic and had been involved in the implementation of new technologies in libraries. Qualitative data analysis software NVivo was used to analyze data and to create themes.FindingsResults indicated that LIS professionals should have advanced technical skills to adopt LD technology in their libraries. Respondents opined that the visibility of library resources and services should be increased on the Web for a wider audience. Findings identified the following challenges in the implementation of LD initiatives in the information environment: MARC standards, low level of awareness, lack of skills among professionals, privacy issues and time barrier. Moreover, information professionals have been contending uncertainties to implement emergent technologies in libraries. However, they are still willing to adopt LD technologies, though these initiatives are at an infancy level in libraries.Social implicationsFindings may be helpful and supportive for professional associations to design training content and for library schools for offering advanced technology courses.Originality/valueThis study will contribute to LIS literature especially in the context of developing countries. It will enhance library professionals’ awareness regarding the significance of LD initiatives in libraries.
What Pakistani doctoral students want? A qualitative exploration of their research experiences
Authors: Hina Batool Syeda , Ali Amna Farzand , Safdar Muhammad 
Published: August 2021

Purpose
This study aims to investigate social sciences PhD scholars’ research experiences through a qualitative lens. Researchers explored the doctoral students’ research conceptions, supervision-related expectations, reasons to join PhD, key learning areas and advantages of PhD in this study. Education sector is rigorously seeking PhD faculty and simultaneously offering a number of research degree programs and scholarships to boom the research culture. The amount of time, energy, finance and dedication involved in it urges researchers to investigate this phenomenon holistically.

Design/methodology/approach
Qualitative research approach, phenomenology (semi-structured interviews) is used to conduct this research, and interpretative phenomenological analysis technique is used to analyze the collected data.

Findings
Findings have been reported comprehensively through interpretative phenomenological analysis. Respondents had a number of expectations from supervisors and viewed this journey as challenging and at the same time beneficial for their professional and personal life.

Originality/value
This study is unique in nature, as it depicts research conceptions of doctoral students, benefits of PhD, challenges in pursuing PhD and supervision expectations from a developing country perspective. This study’s outcomes have impressions for policymakers, researchers and supervisors. The findings have insights for educators to produce more constructive researchers and scholars.
Water–copper nanofluid flow in flat and ribbed microchannels: numerical modeling and optimization
Authors: Dibaji Alireza , Bagherzadeh Seyed Amin , Karimipour Arash 
Published: August 2021

Purpose
This paper aims to simulate the nanofluid forced convection in a microchannel. According to the results, at high Reynolds numbers and higher nanofluid volume fractions, an increase in the rib height and slip coefficient further improved the heat transfer rate. The ribs also affect the flow physics depending on the Reynolds number so that the slip velocity decreases with increasing the nanofluid volume fraction and rib height.

Design/methodology/approach
Forced heat transfer of the water–copper nanofluid is numerically studied in a two dimensional microchannel. The effects of the slip coefficient, Reynolds number, nanofluid volume fraction and rib height are investigated on the average Nusselt number, slip velocity on the microchannel wall and the performance evaluation criterion.

Findings
In contrast, the slip velocity increases with increasing the Reynolds number and slip coefficient. Afterwards, a non-parametric function estimation is performed relying on the artificial neural network.

Originality/value
Finally, the Genetic Algorithm was used to establish a set of optimal decision parameters for the problem
Building resilience for food service businesses in times of crisis: a Four-F action plan
Authors: Bhattacharya Ananya , Zutshi Ambika , Bavik Ali 
Published: August 2021

Purpose
This paper aims to propose a “Four-F (finding facts, fostering alternates, fulfilling implementation and feasibility testing)” action plan to global food service businesses (FSB) such as restaurants (dine-in/take away) to build resilience during times of global crises. The 2019 Coronavirus disease and FSBs apply as working examples elaborating the proposed Four-F action plan with several managerial implications for the internal and external stakeholders of FSBs.

Design/methodology/approach
The method involves reviewing and coding 108 articles using the PRISMA approach, then applying findings to develop the Four-F action plan integrating multiple theoretical concepts (such as stakeholder, crisis management and dynamic capabilities).

Findings
There are two key findings. First, though all four crisis phases should be considered by decision-makers as part of their contingency planning process, the pre and post-crisis stages need higher attention. Second, the Four-F action plan provides specific recommendations to FSBs stakeholders (consumers, suppliers and government) for each crisis phase (pre-crisis, crisis emergence, crisis occurrence and post-crisis).

Originality/value
To the best of the authors’ knowledge, this is the first paper that has incorporated multiple theoretical frameworks (stakeholder theory, crisis management and dynamic capabilities) within the FSBs context and provided the Four-F action plan for decision-makers to understand and manage crisis phases.
Idiosyncratic deals and occupational well-being in the hospitality industry: the mediating role of organization-based self-esteem
Authors: Sun Ning , Song Haiyan , Li Hui 
Published: August 2021

PurposeThis paper aims to investigate how different types of idiosyncratic deals (i-deals) in the hospitality industry enhance occupational well-being (OWB) through organization-based self-esteem (OBSE).Design/methodology/approachIn 2019, 679 questionnaires were distributed to middle- and high-level managerial staff who had worked in high-end hotels in China for at least 1 year, and 642 valid responses were collected. The survey data were analyzed using structural equation modeling. Follow-up interviews were conducted with 20 hotel managers to verify and lend additional support to the survey findings.FindingsBoth task i-deals and career and incentives i-deals positively affected OBSE and OWB, whereas flexibility i-deals negatively affected OBSE. OBSE positively affected OWB, thereby mediating the relationships between the three types of i-deals and OWB.Originality/valueThis study is groundbreaking in its exploration of how various i-deals contribute to OWB through OBSE among middle- and high-level managerial staff. The findings provide initial evidence of the links between i deals, OBSE and OWB and demonstrate how i-deals can address the practical problem of the shortage and loss of competent operational and administrative talent in the hospitality industry.
Mobile payment technology in hospitality and tourism: a critical review through the lens of demand, supply and policy
Authors: Cheng Nancy Tsz Yin , Fong Lawrence Hoc Nang , Law Rob 
Published: August 2021

Purpose
This study aims to offer a comprehensive review of mobile payment (m-payment) research in hospitality and tourism.

Design/methodology/approach
This study systematically reviews 105 m-payment-themed publications retrieved from five research engines including EBSCOhost, Google Scholar, Web of Science, ScienceDirect and Scopus. Content analysis is used to draw insights from the articles.

Findings
Results show that research on m-payment in hospitality and tourism is generally categorized into consumer, supplier and policy dimensions. This study proposes a framework to summarize the demand–supply research standpoints and conditions that qualify research outcomes while providing contemporary policy-related discussions. Four research priorities for future studies are recommended.

Practical implications
Knowledge accumulation and policy-related discussions identified in this study equip practitioners with the opportunities and challenges brought by m-payment. This study provides recommendations according to the factors that drive adoption of m-payment.

Originality/value
This study addresses the academic gaps by critically analyzing m-payment research in hospitality and tourism and identifying four research priorities for future studies.
Diversity and consumer dispositions towards foreign countries in an emerging market
Authors: Güngördü Belbağ Aybegüm 
Published: August 2021

PurposeThe current study builds on social identity theory and realistic conflict theory aims to identify the relationships amongst consumers' ethnocentrism, animosity, discomfort with differences – a factor of universal-diverse orientation (UDO) – and reluctance to purchase German (RELG) and French automobiles (RELF) in the Turkish automobile market which is dominated by foreign brands.Design/methodology/approachEmpirical data were collected via face-to-face surveys from 400 respondents in the emerging market Turkey. Structural equation modelling was employed to examine the direct and indirect effects between the variables.FindingsThe main predictors of the RELG are consumer ethnocentrism, discomfort with differences and economic animosity towards Germany, respectively. Furthermore, RELF in the Turkish market is positively affected by consumer ethnocentrism, war animosity towards France and discomfort with differences, respectively. Discomfort with differences mediates the relationship between consumer ethnocentrism and RELG and RELF.Practical implicationsInternational collaborations with local manufacturers have huge strategic impacts when establishing reliable relationships with Turkish consumers. Foreign companies can initiate socially responsible projects that will relay the message of similarities between cultures to decrease perceived cultural differences. Highlighting the similarities of Turkish consumers with a foreign company in promotional campaigns will be much beneficial.Originality/valueDespite there are many studies regarding antecedents and consequences of consumer ethnocentrism, extant research overlooks the effect of animosity on this concept. Additionally, studies examining UDO in the marketing literature are scarce. This paper integrates UDO, consumer ethnocentrism, animosity and reluctance to purchase foreign products in one study.