bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abordagem da Omalgia nos Cuidados de Saúde Primários: Revisão da Literatura
Authors: Pereira Dias Rosana 
Published: December 2021

A omalgia é a terceira queixa musculoesquelética mais frequente nos cuidados de saúde primários (CSP). Este artigo pretende compreender a omalgia, a sua abordagem diagnóstica e terapêutica nos CSP. Realizou-se uma revisão narrativa. Identificaram-se 73 artigos na pesquisa e incluíram-se na revisão dados de 7 referências bibliográficas. A omalgia é mais frequente no sexo feminino, dos 45 aos 64 anos. Há pior prognóstico se idade avançada, sexo feminino, sintomatologia inicial intensa e associação a cervicalgia. As etiologias mais frequentes são: patologia da coifa dos rotadores, instabilidade e artrose gleno-umeral, capsulite adesiva e patologia da articulação acromioclavicular. Com uma anamnese completa a maioria das situações pode ser diagnosticada e gerida na primeira consulta, sem necessidade de investigação adicional. Quando necessária, a ecografia e a ressonância magnética nuclear são preferíveis. A referenciação a cuidados hospitalares deve ocorrer se queixas refratárias à terapêutica inicial (fármacos analgésicos e anti-inflamatórios e reabilitação física).
Gruss, Susy (2020) <em>Las novelas de Judá Haim Perahiá (Salónica 1886 – Xanthi 1970)</em>. Colección Fuente Clara. Estudios de cultura sefardí. Barcelona: Tirocinio, 394 pp.
Authors: Álvarez López Cristóbal José 
Published: December 2021

Gruss, Susy (2020) Las novelas de Judá Haim Perahiá (Salónica 1886 – Xanthi 1970). Colección Fuente Clara. Estudios de cultura sefardí. Barcelona: Tirocinio, 394 pp. ISBN 978-84-949990-3-1
Features of the Course and Treatment of Hypertension in Combination with Chronicis Chemic Heart Disease in Patients with Gastroesophagel Refluxdisease. Role of Proton Pump Inhibitors Test in the Diagnosis and Treatment of Different Forms of GERD
Authors: Prikhodko Viktoriia , Moreva Diana 
Published: December 2021

The analysis of epidemiological data shows that the prevalence of GERD in Ukraine is 11.1. Prevalence of GERD increases with the age of respondents, which leads to changes in the structure of clinical disease and dominance of extraesophageal manifestations of disease.
The objective: To study features of arterial hypertension (AH) combined with chronic coronary heart disease (CHD) in patients with GERD. Establish a connection presence of gastroesophageal reflux with possible clinical manifestations of coronary heart disease (arrhythmias, ischemic episodes according to the daily ECG monitoring, assessment of the severity of pain in the chest), and parameters of blood pressure and its lability.
Patients and methods. As part of the fragment study examined 50 patients with hypertension I–II art. combined with chronic ischemic heart disease. Methods of examination: antopometric, biochemical blood tests, ambulatory blood pressure monitoring. Holter ECG, upper endoscopy, echocardiography, tests on a scale GerdQ.
Results. Comorbidity of hypertension and chronic ischemic heart disease and GERD is associated with a higher frequency of abdominal type of obesity and metabolic syndrome, which increases the level of cardiovascular risk in patients with GERD. The presence of gastroesophageal reflux disease in patients with hypertension with chronic coronary artery disease causes an increase in the frequency and severity of arrhythmias. Patients on the background of GERD is more common atrial fibrillation (AF). When concomitant GERD in patients with chronic ischemic heart disease was significantly greater frequency and duration of ischemic episodes. Comorbidity with GERD worsens hypertension and characterized by higher rates of SBP and DBP at night and high variability in SBP and DBP during the day.
Conclusion. The presence of GERD in patients with hypertension and chronic ischemic heart disease is associated with more severe clinical manifestations of the underlying disease and can therefore be regarded as complicating CHD- and AH-factor.
Subclinical Hyperthyroidism: Diagnostic Criteria and Principles of Treatment
Authors: Galytska Vita 
Published: December 2021

This article presents the European Thyroid Association guidelines for diagnosis and treatment of subclinical hyperthyroidism, 2015. Determination of thyroid1stimulating hormone levels can help to diagnose a variety of pathological conditions: hypertension, cardiac fibrillation, atrial fibrillation, mineral density reduction in bones, menstrual irregularities, infertility, which require specific treatment after detection of hormonal status disorders (subclinical, overt), taking into account the patient’s age.
Diagnosis of endogenous subclinical hyperthyroidism is based solely on the results of laboratory tests, not clinical criteria. Endogenous subclinical hyperthyroidism is defined by the presence of subnormal levels of thyroid-stimulating hormone with normal levels of free thyroxine, total triiodothyronine, and/or free triiodothyronine. There are two categories of endogenous subclinical hyperthyroidism: stage 1 – the level of thyroid1stimulating hormone is 0,1–0,39 mIU/l; stage 2 – the level of thyroid1stimulating hormone is <0.1 mIU/l. The levels of free thyroxine and free triiodothyronine, as a rule, are medium-high value at a subclinical level of thyroid hormone and can help differentiate between endogenous subclinical hyperthyroidism from overt hyperthyroidism.
It is recommended to study the thyroid-stimulating hormone level as the first test for the diagnosis of subclinical hyperthyroidism. In identifying low levels of thyroid1stimulating hormone it is necessary to investigate the level of free thyroxine, free or bound triiodothyronine. Patients with primary subnormal levels of thyroid-stimulating hormone with concentration of thyroid hormones in the upper limit or in normal range should be evaluated within 2-3 months. It is recommended to perform scintigraphy and possible 24-hour test the absorption of radioactive iodine if in patient with 2nd degree endogenous subclinical hyperthyroidism there is nodular goiter to determine treatment strategy.
Ultrasonography with color Doppler can be informative for patients with endogenous subclinical hyperthyroidism and nodular goiter. Determining the level of antibodies to thyroid-stimulating hormone receptors can confirm the etiology of autoimmune-induced hyperthyroidism.
Study of Efficacy and Safety of Ginger Root Extract in Treatment of Patients with Low Back Pain
Authors: Shuba Neonila , Voronova Tetiana , Hambir Tetiana 
Published: December 2021

The objective: to study efficacy and safety of treatment with herbal formulation of standardized extract of ginger root in patients with low back pain; to study impact of the formulation on the dynamics of inflammation process indices, hepatic and renal markers, purine, carbohydrate and lipid metabolism.
Patients and methods. The study involved 35 patients (28 women and 7 men) aged between 30 and 80 years with primary LBP syndrome. The treatment was provided using herbal formulation of standardized extract of ginger root at dose of 300 mg twice daily during two months. We evaluated efficacy of the formulation using VAS, Oswestry, Roland-Morris, McGill questionnaires. We analyzed effect of the drug product on cytokines levels (IL-1β, IGF-1), NO, CRP, ESR, metabolism indices (lipid, carbohydrate, liver function markers, uric acid levels).
Results. By the end of the study, in 2 months of the treatment, the VAS parameters had statistically significantly decreased from 55,71±2,98 mm to 23,17 mm±2,38, Oswestry parameters – from 16,66±1,09 to 8,69±1,06, McGill parameters – from 8,49±0,73 to 3,09±0,4, Roland-Morris parameters – from 5,37±0,54 to 2,22±0,33. We observed a statistically significant reduction in CRP, ESR, proinflammatory cytokines (IL-1β), free radical (NO), as well as cholesterol and glucose. The study did not demonstrate any dynamics in such laboratory parameters as bilirubin, ALT, AST, creatinine and uric acid.
Conclusions. Based on the study results we concluded that the standardized ginger root extract was effective and safe in treatment of patients with LBP. In the course of the treatment, the patients demonstrated reduction in pain intensity by 58%, life quality improvement by 48%, psycho-emotional state improvement by 59%, and vital activity improvement by 58%. We observed the anti-inflammatory effect of ginger root extract exerted by the drug product through degrading indices of CRP, ESR, proinflammatory cytokine IL-1β, and NO.
The Role of Kallikrein-kinin System in Complex Regional Pain Syndrome I (CRPS I) Pathophysiologic Mechanisms
Authors: Buryanov Oleksandr , Khimion Liudmyla , Kotiuk Viktor 
Published: December 2021

Inflammation, edema and local vascular permeability changes are essential features of the complex regional pain syndrome type I (CRPS I). The role of kallikrein-kinin system components as the major mediators in the development of these symptoms is poorly investigated.
The objective: to investigate the role of kallikrein-kinin system in pathophysiologic mechanisms of CRPS I.
Patients and methods. We have investigated level of prekallikrein (PK), activity of fast-reacting (FRI) and time-dependent (TDI) inhibitors of plasma kallikrein, and blood plasma proteolytic activity (BPPA) in 45 patients with CRPS I and 15 healthy volunteers.
Results. Analysis of kininogenesis activity and sympathetic-adrenal system revealed their close interdependence. Our data corresponds well with the literature information about depressive effect of sympathetic nervous system on kininase activity. This leads to the accumulation of vasoactive peptides in the injures segment of the extremity. Decrease of neurogenic effects at the later stages of CRPS I leads to the fall of the basal kininogenesis level.
Conclusion. Local humoral factors such as the components of kallikrein-kinin system play an important role in CRPS I pathophysiologic mechanisms and are dependent on sympathetic-adrenal system activity.
Cardiac and Psycho-vegetative Abnormalities During Menopause Period and the Ways for Their Therapeutic Correction
Authors: Katerenchuk Ivan 
Published: December 2021

The objective: to study the features of cardiac and autonomic symptoms in women in climacteric period and determination of the effectiveness of Maksipim in the correction of violations.
Patients and methods. There were examined 62 patients perimenopausal and postmenopausal period of life between the ages from 48 to 67 years (average age of 51.2±7,42 years). Women in the control group (n=32) received conventional therapy according to the standards (nitrates, beta-blockers, ACE inhibitors, statins). Women of the controlled group (n=30) on the background of basic therapy were receiving additional Maksipim (STADA, Germany) (active substance 3-hydroxy-6-methyl-2-ethylpyridine succinate) for 5 ml intravenously once a day, 5 injections, then oraly 1 tablet (0.125 g) 3 times a day for 1 month.
Results. The results of these studies showed that menopause lipid disorders, clinical manifestations of angina, presence of hypertension and psycho-vegetative disorders.
Conclusion. Application in complex therapy of patients with coronary heart disease (CHD) combined with arterial hypertension in the menopausal period of the drug Maksipim, helps normalize lipid metabolism, reduce the clinical manifestations of CHD, decrease of blood pressure. Concurrent use Maksipim helps to eliminate manifestations of somatic vegetative and psycho-vegetative disorders, which favorably affects the quality of patients’ life.
Analysis Methods of Use Acupuncture Diagnostics in Multiple Sclerosis Patients Under Comorbidity
Authors: Chupryna Hennadii , Svyrydova Nataliia , Galusha Anatolii 
Published: December 2021

When optimizing the use of acupuncture methods in the complex treatment of patients with MS, important individual approach to treatment is based on a differentiated compilation of recipes acupuncture, built according to the diagnostic data obtained on the basis of current scientific knowledge and understanding of traditional Chinese medicine (TCM)
The objective: to determine the features of these acupuncture diagnostic methods (ADM) in MS patients based on comorbidity and clarify their relationship with the clinical neurological symptoms of MS patients examined.
Patients and methods. ADM was conducted in 216 patients with MS who were divided into 2 groups: without concomitant diseases (n=109) and the presence of concomitant diseases (n=107).
Results. When conducting syndromic ADM according to TCM, in all patients (100%) of us was diagnosed three dominant syndrome of TCM, which we have identified as the main: «spleen qi deficiency», «deficiency of liver and kidney yin», «liver qi stagnation».
Conclusions. As a result of multi-component ADM MS patients were identified pre-emptive involvement in the pathological process of functional systems TCM «Spleen-pancreas», «Kidney», «Liver».
Subclinical Hyperthyroidism: Diagnostic Criteria and Principles of Treatment
Authors: Galitskaya Vita 
Published: December 2021

This article presents the European Thyroid Association guidelines for diagnosis and treatment of subclinical hyperthyroidism, 2015. Determination of thyroid1stimulating hormone levels can help to diagnose a variety of pathological conditions: hypertension, cardiac fibrillation, atrial fibrillation, mineral density reduction in bones, menstrual irregularities, infertility, which require specific treatment after detection of hormonal status disorders (subclinical, overt), taking into account the patient’s age.
Diagnosis of endogenous subclinical hyperthyroidism is based solely on the results of laboratory tests, not clinical criteria. Endogenous subclinical hyperthyroidism is defined by the presence of sub-normal levels of thyroid-stimulating hormone with normal levels of free thyroxine, total triiodothyronine, and/or free triiodothyronine. There are two categories of endogenous subclinical hyperthyroidism: stage 1 – the level of thyroid-stimulating hormone is 0,1–0,39 mIU/l; stage 2 – the level of thyroid-stimulating hormone is <0.1 mIU/l. The levels of free thyroxine and free triiodothyronine, as a rule, are medium-high value at a subclinical level of thyroid hormone and can help differentiate between endogenous subclinical hyperthyroidism from overt hyperthyroidism.
It is recommended to study the thyroid-stimulating hormone level as the first test for the diagnosis of subclinical hyperthyroidism. In identifying low levels of thyroid-stimulating hormone it is necessary to investigate the level of free thyroxine, free or bound triiodothyronine. Patients with primary sub-normal levels of thyroid-stimulating hormone with concentration of thyroid hormones in the upper limit or in normal range should be evaluated within 2-3 months.
It is recommended to perform scintigraphy and possible 24-hour test the absorption of radioactive iodine if in patient with 2nd degree endogenous subclinical hyperthyroidism there is nodular goiter to determine treatment strategy.
Ultrasonography with color Doppler can be informative for patients with endogenous subclinical hyperthyroidism and nodular goiter.
Determining the level of antibodies to thyroid-stimulating hormone receptors can confirm the etiology of autoimmune-induced hyperthyroidism.
The Clinical Course of Irritable Bowel Syndrome in Young Patients with Neurocirculatory Dystonia
Authors: Suprun Olena 
Published: December 2021

The clinical picture of the combined course of irritable bowel syndrome (IBS) and neurocirculatory dystonia (NCD) in young patients has been described in the article. Features of abdominal pain syndrome and disorders of defecation, depending on the type of NCD (hypertonic or hypotonic) were shown.
The conditions under which the exacerbation of IBS occurred in these patients were reviewed. The role of the family doctor in monitoring of the comorbid conditions was shown.
Comparative Efficacy of Infliximab and Budesonide in Treatment of Patients with Ulcerative Colitis
Authors: Niroda Antonina , Bratasyuk Andrii , Chubirko Kseniia , Varvarynets Antonina 
Published: December 2021

The objective: to compare the effectiveness of treatment with infliximab and budesonide in patients with ulcerative colitis (UC).
Patients and methods. 16 patients with UC were included in the study. They were divided into 2 groups. 8 patients in Group I received infliximab, patients in Group II were assigned budesonide.
Results. It was found that in patients, who were treated with infliximab, disease activity significantly decreased by 59,96%, while treatment with budesonide led to a significant reduction of inflammatory activity only by 15,56%. Endoscopic inflammation activity index significantly changed in both groups, but in Group I it has decreased by 50,00%, while in the second group – by 17,70% that corresponds to 1,22±0,44 and 2,00±0,50 points respectively (p<0,05).
Conclusions. The treatment of moderate severity UC effectiveness of infliximab was significantly higher compared to budesonide.
Strengthening of the Motivation for Lifestyle Modification in Patients Receiving the Guar Gum Drug
Authors: Kolesnyk Pavlo , Korol Timea , Shushman Ivanna , Prohorova Aita 
Published: December 2021

The article deals with the question of the prevalence of overweight and obesity among the cohort of mental profession. It determines the level of their motivation for lifestyle changes, as well as possibility to enhance their motivation while using of the guar gum Guarem drug (Orion Corporation, Finland). 161 persons where skinned for diet habits, physical activity, the presence of risk factors as well as dislipidemiya. Motivation for lifestyle changes was evaluated.
It was found that the prevalence of overweight and obesity in population with predominantly mental and light physical labor, is extremely high at 68% women and 73% men and incidence increased with age. While dynamic monitoring of the patients, who underwent motivational counseling while taking the drug guar gum Guarem, noted strengthening of motivation to comply with the recommendations, compared with patients who received only verbal motivation.
About Results of Successive Application Two «Strategies» of Antiviral Therapy of Chronic Hepatitis B Patients
Authors: Nagiyeva Nihiar , Mamedov Murad 
Published: December 2021

The authors presented main results of their clinical observation for 128 chronic hepatitis B (CHB), which underwent antiviral therapy with pegilated interferon for 6 months. 44,5% of these patients had sustained virological response (SVR).
Then 55,5% patients who after therapy had no SVR were additionally treated with one of nucleosides analog for 18 month. Finally 6 month later after end of second therapy SVR was registered at more than 90% of CHB patients.
Prevention of Cardiovascular Disease – Will We Ever Have Time?
Authors: Davydova Iryna , Kozhuharova Nataliia , Konoplianyk Larysa , Simagina Tetiana 
Published: December 2021

In recent years, the rapidly growing incidence of cardiovascular diseases, which are beginning to appear in younger people. There is a need for the primary prevention of cardiovascular disease, i.e. measures to prevent the occurrence of heart disease in healthy people.
However, adherence to medication therapy, prescribed as primary prevention, our population is very low. Development of adverse reactions to medication drugs as they are hypersensitive, allergic addiction, negative reaction on the part of other organs and systems, significantly reduces the effectiveness of treatment.
The way out of this situation may be drugs of medicinal plants, which continue to play a significant role in the arsenal of therapeutic agents. For example, patients with neuro dystonia is considered an advantage of prevention with the use of traditional medicines, the effect of which is aimed at the normalization of the nervous system.
One such drug is Neokardil. Correction of functional changes and move them into organic when NDCs via Neokardin can play a significant role in the prevention of cardiovascular disease.
Social and Medical Aspects of the Association HIV and Herpes Virus Infection in Pregnant Women
Authors: Kaminsky Viacheslav , Anoshina Tetiana , Kolomiychenko Tetiana 
Published: December 2021

The objective: to evaluate the social and health aspects of the association of HIV and herpes infections (GVI) in pregnant women.
Patients and methods. Clinical and statistical analysis of 1177 individual cards of pregnant women with HIV for 5 years. The control group consisted of 200 pregnant women with physiological pregnancy.
Results. Analysis of individual cards of pregnant women with HIV found insufficient to TORCH-infection survey (74,7%). The frequency of herpes infections in HIV-infected patients was 42,3%. The most common laboratory revealed HSV1/2 – 41,9%, CMV – 22,4% and mixed infection (both HSV1/2 and CMV) – 28,1%, other types of AIT is quite rare. At 8,5% of pregnant women stated primary infection herpes viruses, 27,2% – the reactivation of infection. HIV infection is often associated with other infections: hepatitis, fungal infections, toxoplasmosis, papillomavirus infections, respiratory infections, infections of the genitourinary system. Fixed low social status of HIV-infected women with AIT, the presence of harmful habits, a high frequency of co-infections and low compliance to treatment, are additional factors of perinatal risk. History data indicate a high rate of abortions and missed abortion in women with HIV infection and GVI. Going the way of HIV infection with parenteral on sex strengthens the role of herpes virus infection as a cofactor transition from HIV to AIDS, and the development of perinatal complications. The current pregnancy burdened with 84,3% of women: high incidence of placental insufficiency (41,3%), the threat of miscarriage and preterm labor, fetal distress. Maternal mortality in 5 years was noted in 2 cases (0,1‰), both women were GVI, perinatal – in 12 cases, 8 (21,5‰) of them women with AIT. 12,1% of children were born in a state of severe asphyxia, malnutrition with 31,3%, from 3,8% of the children at the end of 1st day intrauterine diagnosed pneumonia.
Conclusions. The high frequency of co-infection of HIV and herpes viruses, joining other infections and comorbidity in these women, their low social adaptation, and susceptibility to treatment, the negative impact of herpes infection in the course of HIV infection, the condition of women during pregnancy, the fetus and the newborn, which requires individual approach to the management of women based on established medical and social aspects of the problem.