bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volume Fraction Measurement of Soft (Dairy) Microgels by Standard Addition and Static Light Scattering
Authors: Heck Anisa , Nöbel Stefan , Hitzmann Bernd , Hinrichs Jörg 
Published: February 2021

AbstractThe volume fraction of the dispersed phase in concentrated soft (dairy) microgels, such as fresh cheese, is directly related to structure and rheology. Measurement or modeling of volume fraction for soft and mechanically sensitive microgel dispersions is problematic, since responsiveness and rheological changes upon mechanical input for these systems limits application of typical functional relationships, i.e., using apparent viscosity. In this paper, we propose a method to measure volume fraction for soft (dairy) microgel dispersions by standard addition and volume-weighted particle size distributions obtained by static light scattering. Relative particle volumes are converted to soft particle volume fraction, based on spiked standard particle volumes. Volume fractions for two example microgel dispersions, namely, differently produced fresh cheeses, were evaluated before and after post-treatments of tempering and mechanical processing. By selecting the size of standard particles based on size ratios and the levels of the mixing ratios/relative fractions, the method could be applied robustly within a wide range of particle sizes (1 to 500 μm) and multimodal size distributions (up to quadmodal). Tempering increased the volume fraction for both example microgel dispersions (P < 0.05). Subsequent mechanical treatment reduced the volume fraction back to the starting value before tempering (P < 0.05). Furthermore, it was shown that the increase and successive decrease in apparent viscosity with tempering and mechanical post-treatments is not exclusively due to particle aggregation and breakdown, but to volume changes of each particle. For environmentally responsive soft matter, the proposed method is promising for measurement of volume fraction.
Criminal Blame, Exclusion and Moral Dialogue
Authors: Porro Costanza 
Published: February 2021

AbstractIn her recent book The Limits of Blame, Erin Kelly argues that we should rethink the nature of punishment because delivering blame is, contrary to the widely held view, not among the justifiable aims of a criminal justice system. In this paper, firstly, I discuss her case against criminal blame. Kelly argues that the emphasis on blame in the criminal justice system and in public discourse is one of the main causes of the stigma and exclusion faced by those convicted for a crime. This claim might appear puzzling and, while she provides other convincing arguments against criminal blame, Kelly does not extensively defend this particular argument. To offer support for this view, I reflect on the often overlooked distinction between moral blame and criminal blame to show how the latter, unlike the former, is exclusionary and stigmatising. Secondly, I address the claim put forth by Kelly that blame should play no role in the criminal justice system at all. In light of her argument about the optional nature of moral blame, I explore the possibility that the state should leave open to victims the option to blame criminal wrongdoers in restorative justice conferences. I argue that in such contexts blame would not have the same exclusionary features of criminal blame in traditional settings and that it could serve some valuable aims articulated by communicative theories of punishment, such as the restoration of moral relationships.
Personality traits, working conditions and health: an empirical analysis based on the German Linked Personnel Panel, 2013–2017
Authors: Bellmann Lutz , Hübler Olaf 
Published: February 2021

AbstractWe conduct a comprehensive analysis of health determinants at the individual and workplace levels. Using a new individual-level German data set, we investigate the influence of these determinants on health, including collegiality, personality traits as measured by the Big Five, commitment to the company and job characteristics, while controlling for a set of standard sociodemographic and employment variables. We are interested in which determinants are important and which are less influential, whether interaction effects should be taken into account and whether the results depend on the modeling and estimation method used. Among the Big Five factors, conscientiousness, agreeableness and emotional stability are positively correlated with good overall health. The influence of job characteristics such as having substantial decision-making authority, not having physically demanding tasks, having pleasant environmental conditions, facing minimal time pressure and not being required to multitask are also positive. If employees frequently receive help when needed from their colleagues and do not feel unfairly criticized by others in the firm, they usually have fewer health problems. Each Big Five item influences mental health, whereas no statistical significance could be found for these items’ relationships with the number of days workers were absent due to sickness, except for neuroticism. These results are, for the most part, robust to different modeling and estimation methods.
Single entity electrochemistry and the electron transfer kinetics of hydrazine oxidation
Authors: Miao Ruiyang , Shao Lidong , Compton Richard G. 
Published: February 2021

AbstractThe mechanism and kinetics of the electro-catalytic oxidation of hydrazine by graphene oxide platelets randomly decorated with palladium nanoparticles are deduced using single particle impact electrochemical measurements in buffered aqueous solutions across the pH range 2–11. Both hydrazine, N2H4, and protonated hydrazine N2H5+ are shown to be electroactive following Butler-Volmer kinetics, of which the relative contribution is strongly pH-dependent. The negligible interconversion between N2H4 and N2H5+ due to the sufficiently short timescale of the impact voltammetry, allows the analysis of the two electron transfer rates from impact signals thus reflecting the composition of the bulk solution at the pH in question. In this way the rate determining step in the oxidation of each specie is deduced to be a one electron step in which no protons are released and so likely corresponds to the initial formation of a very short-lived radical cation either in solution or adsorbed on the platelet. Overall the work establishes a generic method for the elucidation of the rate determining electron transfer in a multistep process free from any complexity imposed by preceding or following chemical reactions which occur on the timescale of conventional voltammetry.
Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines
Authors: Nigro Ersilia , Orlandella Francesca Maria , Polito Rita , Mariniello Raffaela Mariarosaria , Monaco Maria Ludovica , Mallardo Marta , De Stefano Anna Elisa , Iervolino Paola Lucia Chiara , Salvatore Giuliana , Daniele Aurora 
Published: February 2021

AbstractAdiponectin (Acrp30) and leptin, adipokines produced and secreted mainly by the adipose tissue, are involved in human carcinogenesis. Thyroid carcinomas are frequent endocrine cancers, and several evidences suggest that they are correlated with obesity. In this study, we first analyzed the expression levels and prognostic values of Acrp30, leptin, and their receptors in thyroid cancer cells. Then, we investigated the role of Acrp30 and leptin in proliferation, migration, and invasion. We found that Acrp30 treatment alone inhibits cell proliferation and cell viability in a time and dose-dependent manner; leptin alone does not influence thyroid cancer cells (BCPAP and K1) proliferation, but the combined treatment reverts Acrp30-induced effects on cell proliferation. Additionally, through wound healing and Matrigel Matrix invasion assays, we unveiled that Acrp30 inhibits thyroid cancer cell motility, while leptin induces the opposite effect. Importantly, in the combined treatment, Acrp30 and leptin exert antagonizing effects on papillary thyroid cancer cells’ migration and invasion in both BCPAP and K1 cell lines. Highlights of these studies suggest that Acrp30 and leptin could represent therapeutic targets and biomarkers for the management of thyroid cancer.
A critical review of synthesis parameters affecting the properties of zinc oxide nanoparticle and its application in wastewater treatment
Authors: Shaba E. Y. , Jacob J. O. , Tijani J. O. , Suleiman M. A. T. 
Published: February 2021

AbstractIn this era, nanotechnology is gaining enormous popularity due to its ability to reduce metals, metalloids and metal oxides into their nanosize, which essentially alter their physical, chemical, and optical properties. Zinc oxide nanoparticle is one of the most important semiconductor metal oxides with diverse applications in the field of material science. However, several factors, such as pH of the reaction mixture, calcination temperature, reaction time, stirring speed, nature of capping agents, and concentration of metal precursors, greatly affect the properties of the zinc oxide nanoparticles and their applications. This review focuses on the influence of the synthesis parameters on the morphology, mineralogical phase, textural properties, microstructures, and size of the zinc oxide nanoparticles. In addition, the review also examined the application of zinc oxides as nanoadsorbent for the removal of heavy metals from wastewater.
Transforming urban planning processes and outcomes through creative methods
Authors: Cinderby Steve , de Bruin Annemarieke , Cambridge Howard , Muhoza Cassilde , Ngabirano Amanda 
Published: February 2021

AbstractInclusively delivering the sustainable development goals (SDGs) remains challenging, particularly in urban areas, where some of the most pressing concerns exist. To achieve the transformative SDG agenda, new methods are required to overcome current deficits in engagement around inclusion and equitable outcomes. Evaluating against theories of governance and inclusion, we test a mixture of digital and physical creative methods abilities to deliver co-designed solutions that influence mobility and road safety planning outcomes in East African cities. Greater inclusion led to improved interactions of citizens with decision makers, and the identification of novel, practical solutions, delivering some elements of transformation. Risks include creative methods being used to co-opt communities to official agendas, and institutional planning norms needing to adapt to respond to a wider range of stakeholders. Overall, where risks are mitigated, we recommend that using Creative Methods could localise SDG delivery, ensuring more equitable and effective outcomes from infrastructure development investments.
Finite Element Method modeling of Additive Manufactured Compressor Wheel
Authors: Birosz Márton Tamás , Andó Mátyás , Jeganmohan Sudhanraj 
Published: February 2021

AbstractDesigning components is a complex task, which depends on the component function, the raw material, and the production technology. In the case of rotating parts with higher RPM, the creep and orientation are essential material properties. The PLA components made with the material extrusion process are more resistant than VeroWhite (material jetting) and behave similarly to weakly cross-linked elastomers. Also, based on the tensile tests, Young’s modulus shows minimal anisotropy. Multilinear isotropic hardening and modified time hardening models are used to create the finite element model. Based on the measurements, the finite element method simulation was identified. The deformation in the compressor wheel during rotation became definable. It was concluded that the strain of the compressor wheel manufactured with material extrusion technology is not significant.
Numerical analysis and simulation for Rayleigh beam equation with dynamical boundary controls
Authors: Bzeih Moussa , El Arwadi Toufic , Hindi Mohammad 
Published: February 2021

AbstractIn this paper, the Rayleigh beam system with two dynamical boundary controls is treated. Theoretically, the well-posedness of the weak solution is obtained. Later, we discretize the system by using the Implicit Euler scheme in time and the$$P^3$$P3Hermite finite element in space. In addition, we show the decay of the discrete energy and we establish some a priori error estimates. Finally, some numerical simulations are presented.
Predicting Response to Brain Stimulation in Depression: a Roadmap for Biomarker Discovery
Authors: Nord Camilla L. 
Published: February 2021

Abstract
Purpose of Review
Clinical response to brain stimulation treatments for depression is highly variable. A major challenge for the field is predicting an individual patient’s likelihood of response. This review synthesises recent developments in neural predictors of response to targeted brain stimulation in depression. It then proposes a framework to evaluate the clinical potential of putative ‘biomarkers’.

Recent Findings
Largely, developments in identifying putative predictors emerge from two approaches: data-driven, including machine learning algorithms applied to resting state or structural neuroimaging data, and theory-driven, including task-based neuroimaging. Theory-driven approaches can also yield mechanistic insight into the cognitive processes altered by the intervention.

Summary
A pragmatic framework for discovery and testing of biomarkers of brain stimulation response in depression is proposed, involving (1) identification of a cognitive-neural phenotype; (2) confirming its validity as putative biomarker, including out-of-sample replicability and within-subject reliability; (3) establishing the association between this phenotype and treatment response and/or its modifiability with particular brain stimulation interventions via an early-phase randomised controlled trial RCT; and (4) multi-site RCTs of one or more treatment types measuring the generalisability of the biomarker and confirming the superiority of biomarker-selected patients over randomly allocated groups.
The role of health determinants in the influenza vaccination uptake among older adults (65+): a scope review
Authors: Roller-Wirnsberger Regina , Lindner Sonja , Kolosovski Lea , Platzer Elisabeth , Dovjak Peter , Flick Holger , Tziraki Chariklia , Illario Maddalena 
Published: February 2021

Abstract
Background
Although the burden of influenza infection is the highest in older adults, vaccination coverage remains low, despite this age group being more vulnerable than others.

Aims
Given the current pandemic of SARS-CoV-2, it was the aim of this scope review to update knowledge on factors affecting seasonal influenza vaccine uptake among older adults to strengthen prevention approaches in the context of an overall burden of infectious diseases.

Methods
We searched bibliographic databases from 2012 to 2019. All studies reviewed one or more social determinant of health listed by WHO, or factors affecting the decision-making process whether to accept influenza vaccine or not.

Results
Overall, 44 studies were included, 41 determinants were extracted and summarized into six categories. Older age and constitutional factors including multiple chronic diseases as well as preventive lifestyle and frequent routine healthcare utilization positively affected vaccination uptake (VU). Living and working conditions are also researched determinants of influenza vaccine uptake. A small number of studies explored the role of social inclusion and system-based interventions.

Discussion and conclusions
This scope review provides a comprehensive overview on factors affecting seasonal influenza vaccination uptake among older citizens. The review also clearly shows gaps for evidence on system-based level or political strategies to improve vaccination uptake.
Experimental study on permanent deformation characteristics of coarse-grained soil under repeated dynamic loading
Authors: Mei Huihao , Satvati Sajjad , Leng Wuming 
Published: February 2021

AbstractPractical assessment of subgrade settlement induced by train operation requires developing suitable models capable of describing permanent deformation characteristics of subgrade filling under repeated dynamic loading. In this paper, repeated load triaxial tests were performed on coarse-grained soil (CGS), and the axial permanent strain of CGS under different confining pressures and dynamic stress amplitudes was analysed. Permanent deformation behaviors of CGS were categorized based on the variation trend of permanent strain rate with accumulated permanent strain and the shakedown theory. A prediction model of permanent deformation considering stress state and number of load cycles was established, and the ranges of parameters for different types of dynamic behaviors were also divided. The results indicated that the variational trend of permanent strain rate with accumulated permanent strain can be used as a basis for classifying dynamic behaviors of CGS. The stress state (confining pressure and dynamic stress amplitude) has significant effects on the permanent strain rate. The accumulative characteristics of permanent deformation of CGS with the number of load cycles can be described by a power function, and the model parameters can reflect the influence of confining pressure and dynamic stress amplitude. The study’s results could help deepen understanding of the permanent deformation characteristics of CGS.
Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model
Authors: Comeglio P. , Sarchielli E. , Filippi S. , Cellai I. , Guarnieri G. , Morelli A. , Rastrelli G. , Maseroli E. , Cipriani S. , Mello T. , Galli A. , Bruno B. J. , Kim K. , Vangara K. , Papangkorn K. , Chidambaram N. , Patel M. V. , Maggi M. , Vignozzi L. 
Published: February 2021

Abstract
Purpose
Low free testosterone (T) level in men is independently associated with presence and severity of Non-Alcoholic Steatohepatitis (NASH). The histological and molecular effects of oral testosterone prodrug LPCN 1144 treatment on hepatic fibrosis and NASH features are unknown. A metabolic syndrome-induced NASH model in rabbits consuming high fat diet (HFD) has been previously used to assess treatment effects of injectable T on hepatic fibrosis and NASH features. Here we present results on LPCN 1144 in this HFD-induced, NASH preclinical model.

Methods
Male rabbits were randomly assigned to five groups: regular diet (RD), HFD, HFD + 1144 vehicle (HFD + Veh), HFD + 1144 (1144), and HFD + 1144 + α-tocopherol (1144 + ALPHA). Rabbits were sacrificed after 12 weeks for liver histological, biochemical and genetic analyses. Histological scores were obtained through Giemsa (inflammation), Masson’s trichrome (steatosis and ballooning), and Picrosirius Red (fibrosis) staining.

Results
Compared to RD, HFD and HFD + Veh significantly worsened NASH features and hepatic fibrosis. Considering HFD and HFD + Veh arms, histological and biomarker features were not significantly different. Both 1144 and 1144 + ALPHA arms improved mean histological scores of NASH as compared to HFD arm. Importantly, percentage of fibrosis was improved in both 1144 (p < 0.05) and 1144 + ALPHA (p = 0.05) treatment arms vs. HFD. Both treatment arms also reduced HFD-induced inflammation and fibrosis mRNA markers. Furthermore, 1144 treatments significantly improved HFD-induced metabolic dysfunctions.

Conclusions
Histological and biomarker analyses demonstrate that LPCN 1144 improved HFD-induced hepatic fibrosis and NASH biochemical, biomolecular and histochemical features. These preclinical findings support a therapeutic potential of LPCN 1144 in the treatment of NASH and of hepatic fibrosis.
Obesità post-neurochirurgia ipotalamica
Authors: Bo Simona , Ponzo Valentina , Pellegrini Marianna , Grottoli Silvia 
Published: February 2021

SommarioLe malattie ipotalamiche e il loro trattamento chirurgico possono determinare un rapido incremento ponderale nei primi sei mesi, seguito da stabilizzazione del peso in un’elevata percentuale (40–80%) di pazienti. Gli interventi sullo stile di vita e i farmaci hanno fornito risultati insoddisfacenti. Maggiori benefici sono stati riportati con gli analoghi del glucagon like peptide-1 o con la chirurgia bariatrica ma gli studi ad oggi disponibili sono di bassa numerosità e di breve durata.
Is Wilson’s religion Durkheim’s, or Hobbes’s Leviathan?
Authors: Atkinson Andrew R. 
Published: February 2021

AbstractThis paper critically supports the modern evolutionary explanation of religion popularised by David Sloan Wilson, by comparing it with those of his predecessors, namely Emile Durkheim and Thomas Hobbes, and to some biological examples which seem analogous to religions as kinds of superorganisms in their own right. The aim of the paper is to draw out a theoretical pedigree in philosophy and sociology that is reflected down the lines of various other evolutionarily minded contributors on the subject of religion. The general theme is of evolved large-scale cooperative structures. A scholarly concern is as follows: Wilson (Darwin’s Cathedral: Evolution, Religion, And The Nature Of Society, University of Chicago Press, Chicago, 2002) draws on Durkheim, (The elementary forms of religious life. Free Press, New york, 1912) using Calvinism as an example without mentioning Hobbes (Leviathan, Edited by E. Curley, Cambridge, Hackett, 1651), but it was Thomas Hobbes (1588–1679) who used Calvinism as an example of a leviathanesque religious structure—which is not acknowledged by either Wilson or Durkheim. If there are even any similarities between these authors, there appears to be an omission somewhere which should rightly be accounted for by giving credit to Hobbes where it is due. I issue on conclusion, what it is that makes Wilson’s approach radically different to that it skates on. I also issue it with a cautionary word.
Mathematics in the Digital Age: The Case of Simulation-Based Proofs
Authors: Sümmermann Moritz Lucius , Sommerhoff Daniel , Rott Benjamin 
Published: February 2021

AbstractDigital transformation has made possible the implementation of environments in which mathematics can be experienced in interplay with the computer. Examples are dynamic geometry environments or interactive computational environments, for exampleGeoGebraorJupyter Notebook, respectively. We argue that a new possibility to construct and experience proofs arises alongside this development, as it enables the construction of environments capable of not only showing predefined animations, but actually allowing user interaction with mathematical objects and in this way supporting the construction of proofs. We precisely define such environments and call them “mathematical simulations.” Following a theoretical dissection of possible user interaction with these mathematical simulations, we categorize them in relation to other environments supporting the construction of mathematical proofs along the dimensions of “interactivity” and “formality.” Furthermore, we give an analysis of the functions of proofs that can be satisfied by simulation-based proofs. Finally, we provide examples of simulation-based proofs inAriadne, a mathematical simulation for topology. The results of the analysis show that simulation-based proofs can in theory yield most functions of traditional symbolic proofs, showing promise for the consideration of simulation-based proofs as an alternative form of proof, as well as their use in this regard in education as well as in research. While a theoretical analysis can provide arguments for the possible functions of proof, they can fulfil their actual use and, in particular, their acceptance is of course subject to the sociomathematical norms of the respective communities and will be decided in the future.