bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disorder specific rewarding stimuli in anorexia nervosa
Authors: Kogel Ann‐Kathrin , Herpertz Stephan , Steins‐Loeber Sabine , Diers Martin 
Published: May 2021

AbstractObjectiveTo enhance our understanding of reward stimuli in anorexia nervosa (AN) and to provide a basis for future research on reward processes, disorder specific reward stimuli as well as primary and secondary reinforcers were investigated.MethodWe developed a set of pictures with “disorder specific reward” stimuli, with the six subcategories “sport,” “losing weight,” “healthy food,” “discipline,” “thin bodies,” “appreciation of others,” and evaluated reward ratings of these “disorder specific reward” stimuli as well as “erotic,” “high caloric,” and “neutral” stimuli in 25 patients with AN and 25 participants in the comparison group (CG).ResultsWe found a significant main effect for picture category and a significant interaction. The reward ratings were higher in patients with AN compared with CG for the “disorder specific reward” stimuli. In the reward subcategories, patients with AN had higher reward ratings compared with CG in all categories except of healthy food. The “disorder specific reward” stimuli of the categories “sport,” “losing weight,” and “healthy food” showed higher reward ratings compared with the categories “discipline,” “thin bodies,” and “appreciation of others” in patients with AN.DiscussionThe previously used category “thin bodies” used to investigate the reward system might be less effective compared with stimuli from the categories “sport,” “losing weight,” and “healthy food.”
An index for measuring functional extension and evenness in trait space
Authors: Zhang Tao , Domke Grant M. , Russell Matthew B. , Lichstein Jeremy W. 
Published: May 2021

AbstractMost existing functional diversity indices focus on a single facet of functional diversity. Although these indices are useful for quantifying specific aspects of functional diversity, they often present some conceptual or practical limitations in estimating functional diversity. Here, we present a new functional extension and evenness (FEE) index that encompasses two important aspects of functional diversity. This new index is based on the straightforward notion that a community has high diversity when its species are distant from each other in trait space. The index quantifies functional diversity by evaluating the overall extension of species traits and the interspecific differences of a species assemblage in trait space. The concept of minimum spanning tree (MST) of points was adopted to obtain the essential distribution properties for a species assembly in trait space. We combined the total length of MST branches (extension) and the variation of branch lengths (evenness) into a raw FEE0 metric and then translated FEE0 to a species richness‐independent FEE index using a null model approach. We assessed the properties of FEE and used multiple approaches to evaluate its performance. The results show that the FEE index performs well in quantifying functional diversity and presents the following desired properties: (a) It allows a fair comparison of functional diversity across different species richness levels; (b) it preserves the essence of single‐facet indices while overcoming some of their limitations; (c) it standardizes comparisons among communities by taking into consideration the trait space of the shared species pool; and (d) it has the potential to distinguish among different community assembly processes. With these attributes, we suggest that the FEE index is a promising metric to inform biodiversity conservation policy and management, especially in applications at large spatial and/or temporal scales.
Biomimetic Total Syntheses of Amorfrutins A, B, (S)‐D and (R)‐D and Formal Synthesis of Amorfrutin C
Authors: Mies Thomas , Patel Calum , Parsons Philip J. , Barrett Anthony G. M. 
Published: May 2021

AbstractBibenzyl natural products, such as the amorfrutins, contain a heavily substituted aromatic core and display a diverse range of biological activities (anti‐tumor, anti‐diabetic, antimicrobial, and antibiotic). In this study, we report unified syntheses of amorfrutin A to D either through total or formal synthesis by employing a dual biomimetic strategy of polyketide aromatization followed by remote terpene functionalization. The key core structures were synthesized from β‐keto dioxinone esters through a magnesium(II) mediated regioselective C‐acylation, palladium catalyzed decarboxylative allylic rearrangement, and dehydrative cyclization.
Bendable ultra‐high frequency radio‐frequency identification tag antenna for retail garments using nonuniform meandered lines
Authors: Kumar Manoj , Sharma Ashwani , Garcia Zuazola Ignacio J. 
Published: May 2021

AbstractA bendable ultra‐high frequency (UHF) radio‐frequency identification (RFID) tag antenna using nonuniform meandered lines for retail garments in the textile industry is presented. Based on an earlier UHF RFID tag antenna using nonuniform meandered lines, the proposed tag is fully bendable and aimed to be embedded in retail garments for long‐life cycles. As a result, a relatively low cost, wideband, compactness, and good conjugate matching with good dipole‐like read range is presented. Results showed an antenna with a wide bandwidth of 900 MHz and a long read range of 10.1 m making the UHF RFID tag antenna using nonuniform meandered lines a potential candidate for retail garments in bendable applications of the textile industry. Simulations are corroborated by measurements and are in fairly agreement.
Bayesian estimation of heterogeneous environments from animal movement data
Authors: Tishkovskaya Svetlana V. , Blackwell Paul G. 
Published: May 2021

AbstractWe describe a flexible class of stochastic models that aim to capture key features of realistic patterns of animal movements observed in radio‐tracking and global positioning system telemetry studies. In the model, movements are represented as a diffusion‐based process evolving differently in heterogeneous regions. In this article, we extend the process of inference for heterogeneous movement models to the case in which boundaries of habitat regions are unknown and need to be estimated. Data augmentation is used in reconstructing the partition of the heterogeneous environment. The augmentation helps to diminish the impact of uncertainty about when and where the animal crosses habitat boundaries, and allows the extraction of additional information from the given observations. The approach to inference is Bayesian, using Markov chain Monte Carlo methods, allowing us to estimate both the parameters of the diffusion processes and the unknown boundaries. The suggested methodology is illustrated on simulated data and applied to real movement data from a radio‐tracking experiment on ibex. Some model checking and model choice issues are also discussed.
Eating behaviour and symptom trajectories in patients with a history of binge eating disorder during COVID‐19 pandemic
Authors: Giel Katrin E. , Schurr Marisa , Zipfel Stephan , Junne Florian , Schag Kathrin 
Published: May 2021

AbstractObjectiveA history of an eating disorder (ED) might constitute a risk for symptom deterioration and relapse during COVID‐19 pandemic. This longitudinal study investigates ED symptom trajectories until the first COVID‐19 lockdown in Spring 2020 in patients with a history of binge eating disorder (BED).MethodParticipants of the randomised‐controlled BED treatment trial IMPULS participated in a re‐assessment directly after the first COVID‐19 lockdown in Germany. We used expert‐rated clinical interviews and self‐report to investigate binge eating (BE) frequency, ED and general psychopathology, distress, emotion regulation and sense of coherence. Symptom trajectories were analysed for baseline when entering the trial, end of trial participation and the time point directly after lockdown. BE frequency was assessed on a recall basis for 4 weeks directly before lockdown and 4 weeks during lockdown.ResultsBE frequency, general ED pathology and depressive symptoms markedly increased after as compared to before the COVID‐19 outbreak. Individuals scoring high on reappraisal as emotion regulation strategy and sense of coherence scored lower on general ED pathology.ConclusionIndividuals with a history of an ED are at risk for symptom deterioration and relapse during the pandemic. Intervention and service dissemination strategies are needed to support vulnerable groups throughout the pandemic.
Selective rounding for pyramid peaks and valleys improves the performance of SHJ solar cells
Authors: Du Junlin , Meng Fanying , Fu Haoxin , Sun Lin , Zhang Liping , Han Anjun , Shi Jianhua , Xie Yi , Liu Zhengxin 
Published: May 2021

AbstractThe first step in the fabrication of SHJ (silicon heterojunction) solar cells is forming random pyramids on the Si wafer surfaces. The pyramid profile would affect the following amorphous silicon deposition. Two CP (chemical polishing) solutions consist of HNO3 + HF and O3 + HF, respectively, are used to modify the pyramid profile. It is found that these two solutions have selective rounding effects on the pyramid profiles. The first one rounds the pyramid valleys and the second one rounds the pyramid peaks. The combination of the two CP methods improves the passivation quality of amorphous silicon and promotes the conversion efficiency of SHJ cells.
Quantifying the influence of rainfall, vegetation and animals on soil erosion and hillslope connectivity in the monsoonal tropics of northern Australia
Authors: Hancock Greg , Lowry John 
Published: May 2021

AbstractErosion of soil by water is facilitated by both diffusive and fluvial processes. Here we examine three different soil redistribution processes operating at very different spatial and temporal scales in the monsoonal tropics of northern Australia. The first process, rainsplash, operates across the entire catchment. This process, while subject to annual and seasonal variations in rainfall amount and intensity, can be considered a constant forcing and redistributes on average 9 t ha−1 year−1 (range −0.9 to 19 t ha−1 year−1). The second process, bioturbation, where in this study soil is disturbed by feral pigs (wild boar), occurs in selected areas throughout each year. Pigs exhume 3 to 36.0 t ha−1 year−1 (average ~11 t ha−1 year−1). The effect of this disturbance may last for many years afterwards. The third process is the disturbance of the soil surface by tree throw and creation of pit–mound topography (also a form of bioturbation), together with the resultant placement of the tree superstructure (above ground biomass) on the ground, which may form debris dams. Tree throw at the scale examined here is likely to occur only once every 50–100 years, with the influence of this single event lasting for at least 10 years post event. Tree throw in a single event exhumed ~5 t ha−1 (1.1–9.5 t ha−1) of soil. In contrast to rainsplash, pig disturbance and tree throw events are largely point‐based phenomena. Field observation suggests that it takes many years for the disturbance from both pigs and tree throw to be removed. We find here that in terms of relative soil redistribution, rainsplash has the largest influence, with any erosional disturbance by pigs and tree throw being within the variability of rainsplash. However, the disruption of surface flow by the pig digs and tree throw disrupts sedimentological and hydrological connectivity.
The effect of food ration bar enriched with β‐alanine, L‐arginine, and Nigella sativa on performance and inflammation following intense military training: A double‐blind randomized clinical trial
Authors: Hadi Saeid , Miryan Mahsa , Soleimani Davood , Amani Reza , Mazaheri Tehrani Mostafa , Hadi Vahid , Esmaiil Zali Morad , Mosalmanzadeh Negin , Askari Gholamreza 
Published: May 2021

AbstractBackgroundThere are growing interests in using dietary supplements to improve athletic performance. This study aimed to evaluate the effect of the food ration bar enriched with β‐alanine, L‐arginine, and Nigella sativa on athletic performance and inflammation following intense military training.MethodsThis double‐blind, randomized, controlled clinical trial was conducted on 54 new cadets. Eligible participants were randomly assigned in a 1:1 ratio to receive food ration bars enriched with arginine (2 g/day), β‐alanine (2 g/day), and Nigella sativa (2 g/day) or nonenriched food ration bars during a 2‐week military training. Aerobic and anaerobic performances were evaluated by the Cooper and RAST tests, respectively.ResultsA significant increase in anaerobic powers (min, mean, and max) and a significant reduction in fatigue index were observed in the intervention group as compared to the control group, even after the adjustment for confounding factors. Also, increased levels of hs‐CRP and TNF‐α following military training were significantly lower in the intervention group as compared to the control group (hs‐CRP: 0.55 ± 0.1 versus 2.43 ± 0.1 mg/L; p‐value: 0.01; TNF‐α: 0.12 ± 0.04 versus 0.62 ± 0.04 pg/ml; p‐value: 0.03). No significant changes were observed in VO2 max in both groups.ConclusionsOur results showed that the combination of β‐alanine, L‐arginine, and Nigella sativa can improve anaerobic performance and reduce inflammation following intense physical activities. Further studies with long‐term duration are needed to confirm the cumulative/synergic effects of these ingredients in trained and nontrained subjects.
Assessment of captive rearing conditions on loggerhead hatchlings: Effect of handling frequency and stocking density
Authors: Usategui‐Martín Alejandro , Liria‐Loza Ana , Valverde Roldán A. , Pinós‐Crosas Judit , Tuya Fernando , Carbajal Annaïs , López‐Bejar Manel , Montero Daniel 
Published: May 2021

AbstractFrequently, stranded sea turtles require rehabilitation under controlled conditions. Currently, few publications have described the conditions under which rehabilitation is to take place, particularly with respect to the hatchling life stage. To address this paucity of data, we conducted some experiments to assist rehabilitating facilities assess their handling of hatchlings. While in captivity, hatchlings are routinely handled, for example, for data collection and cleaning. Standardization of handling and housing protocols is necessary to define the most adequate rearing conditions to maintain hatchling welfare. Accordingly, the aim of this study was to assess plasma circulating corticosterone (Cort) concentration and growth, as a biomarker for the stress of hatchling loggerhead sea turtles (Caretta caretta) under controlled conditions. We performed two experiments to analyze handling frequency and stocking density. In both, Cort was measured and correlated with variations in animal weight and length. In handling experiments, Cort exhibited no significant increase when hatchlings were handled once a week, whereas Cort was significantly elevated when hatchlings were handled once every 2 weeks, suggesting that hatchlings have the ability to acclimate to frequent handling. However, hatchlings exhibited similar growth and mortality, regardless of handling regime. In stocking density experiments, hatchling isolation induced a significant elevation of Cort, in comparison with hatchlings placed with conspecifics at increasing densities. Growth increased in singly housed hatchlings, while mortality increased in tanks with three or more hatchlings. The results obtained suggest that Cort, growth, and mortality should be measured to assess hatchling welfare when kept under controlled conditions.
Diagnostic accuracy of fecal calprotectin in predicting significant gastrointestinal diseases
Authors: Kan Yee Man , Chu Sin Yan , Loo Ching Kong 
Published: May 2021

AbstractBackground and AimIt is often unreliable to triage patients for timely endoscopic investigations based on symptoms alone. We need an objective assessment to differentiate between organic gastrointestinal diseases and functional bowel symptoms. We evaluated the diagnostic accuracy of fecal calprotectin (FC) in predicting organic gastrointestinal diseases.MethodsIn a prospective observational study, consecutive patients referred for colonoscopy to the Department of Medicine and Geriatrics at the Kwong Wah Hospital in Hong Kong were recruited. Stool samples were collected within 24 h before colonoscopy. FC was measured by a commercial kit. Upper endoscopy investigations were then proceeded if normal colonoscopy but elevated FC.ResultsTwo hundred and seventy out of 429 patients had FC above 50 μg/g. Eighty‐six out of 270 with elevated FC had significant colonoscopy pathological findings. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FC test for diagnosing a significant organic colonoscopy or upper endoscopy disease were 91.7, 55.6, 57.0, and 91.2%, respectively. The NPV of FC for colorectal cancer, high risk polyp, and colon inflammation were 98.7, 96.2, and 98.1%, respectively. The NPV of FC in the condition of altered bowel habit or abdominal pain in predicting colorectal cancer and inflammation were 93.8 and 100%, respectively.ConclusionsFC is a reliable marker of ruling out organic bowel diseases. A single negative FC test could be used as a triage tool to prioritize the need and urgency of further investigation, particularly in the setting of altered bowel habits and abdominal pain.
Prevalence and antimicrobial susceptibility of Gram‐negative bacilli in subgingival biofilm associated with periodontal diseases
Authors: Espíndola Laís Christina Pontes , Picão Renata Cristina , Mançano Stella Maria Casas Novas , Martins do Souto Renata , Colombo Ana Paula Vieira 
Published: May 2021

AbstractBackgroundThis cross‐sectional study aimed to determine the prevalence and antimicrobial susceptibility of Gram‐negative bacilli (GNB) isolated from subgingival biofilm of individuals with different periodontal conditions.MethodsSubgingival biofilm was obtained from 362 individuals with periodontal health (PH) (n = 83), gingivitis (n = 74), and periodontitis (n = 205), cultivated in broth and selective media. Isolated strains were identified by mass spectrometry. Antimicrobial susceptibility was determined by the Clinical and Laboratory Standards Institute disk diffusion guidelines. Production of extended‐spectrum beta‐lactamase (ESBL) and carbapenemases were evaluated by double disk synergy test and spectrophotometric detection of imipenem hydrolysis, respectively. ESBL and carbapenemase encoding genes were surveyed by Polymerase chain reaction (PCR). Differences among groups were examined by Chi‐square, Kruskal‒Wallis or Mann‐Whitney tests.ResultsGNB were isolated from 36.2% of all subgingival biofilm samples, with a significantly greater prevalence and species diversity (P < 0.001) in patients with periodontitis (45.9%) compared with individuals with PH (24.1%) and gingivitis (22.9%). Pseudomonas aeruginosa (27.5%), Enterobacter cloacae (16.8%), and Enterobacter asburiae (10.7%) were the most predominant species. Resistance/reduced sensitivity to at least 1 antimicrobial was detected in 60% of the strains, but only 4.6% were multidrug resistant. Serratia marcescens, E. cloacae, and Enterobacter kobei presented high rates of intrinsic resistance (>40%) to amoxicillin‐clavulanate and first/second‐generations of cephalosporins. One strain of Klebsiella pneumoniae isolated from periodontitis was resistant to imipenem, but no ESBL encoding genes or ESBL phenotype was detected.ConclusionHigh prevalence and diversity of GNB, with low susceptibility to β‐lactams are observed in the subgingival microbiota associated with periodontitis.
Intratympanic Lipopolysaccharide Elevates Systemic Fluorescent Gentamicin Uptake in the Cochlea
Authors: Chai Yongchuan , He Weiwei , Yang Weiqiang , Hetrick Alisa P. , Gonzalez Jessica G. , Sargsyan Liana , Wu Hao , Jung Timothy T. K. , Li Hongzhe 
Published: May 2021

Objectives/HypothesisLipopolysaccharide (LPS), a key component of bacterial endotoxins, activates macrophages and triggers the release of inflammatory cytokines in mammalian tissues. Recent studies have shown that intratympanic injection of LPS simulates acute otitis media (AOM) and results in morphological and functional changes in the inner ear. Here we established an AOM mouse model with LPS to investigate the uptake of ototoxic gentamicin in the inner ear, and elucidated the underlying mechanism by focusing on cochlear inflammation as a result of AOM.Study DesignPreclinical rodent animal model.MethodsFluorescently tagged gentamicin (GTTR) was systemically administered to mice with AOM. Iba1‐positive macrophage morphology and inner ear cytokine profile were evaluated by immunofluorescence technique and a mouse cytokine array kit, respectively.ResultsWe observed characteristic symptoms of AOM in the LPS‐treated ears with elevated hearing thresholds indicating a conductive hearing loss. More importantly, the LPS‐induced AOM activated cochlear inflammatory responses, manifested by macrophage infiltration, particularly in the organ of Corti and the spiral ligament, in addition to the up‐regulation of proinflammatory cytokines. Meanwhile, GTTR uptake in the stria vascularis and sensory hair cells from all the LPS‐treated ears was significantly enhanced at 24, 48, and 72‐hour post‐treatment, as the most prominent enhancement was observed in the 48‐hour group.ConclusionIn summary, this study suggests that the pathological cochlea is more susceptible to ototoxic drugs, including aminoglycosides, and justified the clinical concern of aminoglycoside ototoxicity in the AOM treatment. Laryngoscope, 131:E2573–E2582, 2021
Advanced paramedics and nurses can deliver safe and effective pre‐hospital and in‐hospital emergency care: An integrative review
Authors: Jansson Jörgen , Larsson Maria , Nilsson Jan 
Published: May 2021

AbstractAimTo explore and present an overview of scope of practice among registered nurses and paramedics with an advanced level of education in pre‐hospital and in‐hospital emergency care.DesignAn integrative literature review.MethodStudies published between 2006 and 2018 were retrieved by searching the databases CINAHL, PubMed, Scopus and Web of Science. Studies were selected by three independent researchers, and data were synthesized using thematic analysis.ResultsThe 25 studies identified focused on in‐hospital (n = 15) and pre‐hospital emergency care (n = 10) and included 13 professional titles originated from seven countries. The thematic analysis disclosed four themes; “Versatile care,” “Safe care based on precision and accuracy,” “Autonomous performance within boundaries” and “Beneficial towards patients and society.” Advanced paramedics’ and advanced nurses’ services are characterized as safe, of high quality and of public benefit. Their services are being used in everyday practice as well as directed to certain categories of patients.