bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic surgery for colorectal cancer in the Octogenarians
Authors: Westrich Gal , Mykoniatis Ioannis , Stefan Samuel , Siddiqi Najaf , Ahmed Yousra , Cross Matthew , Nissan Aviram , Khan Jim S 
Published: April 2021

AbstractBackgroundWe evaluated the short‐term outcomes of robotic colorectal cancer surgery in octogenarian patients, focussing on postoperative morbidity and survival.MethodsAll patients ≥80 years in a prospective colorectal cancer database undergoing robotic curative colorectal cancer resection were included. Patient demographics, intraoperative findings, postoperative and oncological outcomes were recorded. Patients were further subdivided into two groups named: old (OG 80–85 years) and very old (VOG ≥ 86 years).ResultsFifty‐eight consecutive patients were included (median age, 83 years; male, 53.4%; median BMI, 26.5). Median total operative time was 230 min, median blood loss 20 ml, median length of stay 7 days. Major complications were seen in 12% of patients; and the 90‐day mortality rate was 1.7%. Complete R0 resection achieved in 93% of cases, average lymph node harvest was 22. Overall and disease‐free survival was 81% and 87.3%, respectively (median follow‐up 24.5 months). We noticed a trend towards more advanced lesion staging in the VOG, but only N2 stage was significant (p = 0.03). There was a statistically significant difference in overall survival in favour of the OG (p = 0.024).ConclusionsRobotic surgery is feasible in octogenarian patients undergoing curative colorectal cancer resection and is associated with good post‐operative outcomes and overall survival.
Synthesis of Glucosyl Amino Acid Derivatives for Obtaining N‐Glucopeptides via SPPS: Optimization of the Synthetic Route**
Authors: Rodríguez Verónica , Román Julieth , Insuasty‐Cepeda Diego , Fierro‐Medina Ricardo , Rivera‐Monroy Zuly , García‐Castañeda Javier 
Published: April 2021

AbstractBuilding blocks of Fmoc‐Asn‐β‐(2,3,4,6‐tetra‐O‐Acetyl‐D‐glucopyranosyl)‐OH (5) Fmoc‐Asn‐β‐(2,3,4,6‐tetra‐O‐Acetyl‐D‐mannopyranosyl)‐OH (5 a), and Fmoc‐Asn‐β‐(2,3,4,6‐tetra‐O‐Acetyl‐D‐galactopyranosyl)‐OH (5 b) were synthesized from D‐glucose, D‐mannose, and D‐galactose, respectively. The final products and their intermediates were characterized by means of NMR experiments. The synthetic route was optimized, and scaling to obtain 5 g of the Fmoc‐Asn‐β‐(2,3,4,6‐tetra‐O‐Acetyl‐D‐glucopyranosyl)‐OH significantly diminished the amount of solvents and reagents consumed, yielding a faster, cheaper and easy to implement process. The methodology developed allowed obtaining the building blocks with good yields and high purity with only one purification process. The Fmoc‐Asn‐β‐(2,3,4,6‐tetra‐O‐Acetyl‐D‐glucopyranosyl)‐OH building block (5) was used to synthetized N‐glycopeptides derived from LfcinB. The results showed that the incorporation of the building block into the growing chain significantly affects the synthetic process using the SPPS (Solid Phase Peptide Synthesis) Fmoc/tBu strategy. It was established that the position of the building block in the sequence, as well the number of the building blocks incorporated, diminished the yields and purity of the final product. The methodologies reported could be used to synthetized building blocks containing monosaccharides and could contribute to improving N‐glycopeptide synthesis.
More on topological vertex formalism for 5-brane webs with O5-plane
Authors: Hayashi Hirotaka , Zhu Rui-Dong 
Published: April 2021

Abstract
We propose a concrete form of a vertex function, which we call O-vertex, for the intersection between an O5-plane and a 5-brane in the topological vertex formalism, as an extension of the work of [1]. Using the O-vertex it is possible to compute the Nekrasov partition functions of 5d theories realized on any 5-brane web diagrams with O5-planes. We apply our proposal to 5-brane webs with an O5-plane and compute the partition functions of pure SO(N) gauge theories and the pure G2 gauge theory. The obtained results agree with the results known in the literature. We also compute the partition function of the pure SU(3) gauge theory with the Chern-Simons level 9. At the end we rewrite the O-vertex in a form of a vertex operator.
Oscillating multiple giants
Authors: Suzuki Ryo 
Published: April 2021

AbstractWe propose a new example of the AdS/CFT correspondence between the system of multiple giant gravitons inAdS5× S5and the operators withO(Nc) dimensions in$$ \mathcal{N} $$N= 4 super Yang-Mills. We first extend the mixing of huge operators on the Gauss graph basis in the$$ \mathfrak{su}(2) $$su2sector to all loops of the ’t Hooft coupling, by demanding the commutation of perturbative Hamiltonians in an effective U(p) theory, wherepcorresponds to the number of giant gravitons. The all-loop dispersion relation remains gapless at anyλ, which suggests that harmonic oscillators of the effective U(p) theory should correspond to the classical motion of the D3-brane that is continuously connected to non-maximal giant gravitons.
Anisotropic Robin problems with logistic reaction
Authors: Papageorgiou Nikolaos S. , Rădulescu Vicenţiu D. , Tang Xianhua 
Published: April 2021

AbstractWe consider Robin problems driven by the anisotropicp-Laplace operator and with a logistic reaction. Our analysis covers superdiffusive, subdiffusive and equidiffusive equations. We examine all three cases, and we prove multiplicity properties of positive solutions (superdiffusive case) and uniqueness (subdiffusive and equidiffusive cases). The equidiffusive equation is studied only in the context of isotropic operators. We explain why the more general case cannot be treated.
The epidemiology of overtransfusion of red cells in trauma resuscitation patients in the context of a mature massive transfusion protocol
Authors: Cowan Timothy , Weaver Natasha , Whitfield Alexander , Bell Liam , Sebastian Amanda , Hurley Stephen , King Kate L. , Fischer Angela , Balogh Zsolt J. 
Published: April 2021

Abstract
Purpose
Packed red blood cell (PRBC) transfusion remains an integral part of trauma resuscitation and an independent predictor of unfavourable outcomes. It is often administered urgently based on clinical judgement. These facts put trauma patients at high risk of potentially dangerous overtransfusion. We hypothesised that trauma patients are frequently overtransfused and overtransfusion is associated with worse outcomes.

Methods
Trauma patients who received PRBCs within 24 h of admission were identified from the trauma registry during the period January 1 2011–December 31 2018. Overtransfusion was defined as haemoglobin concentration of greater than or equal to 110 g/L at 24 h post ED arrival (± 12 h). Demographics, injury severity, injury pattern, shock severity, blood gas values and outcomes were compared between overtransfused and non-overtransfused patients.

Results
From the 211 patients (mean age 45 years, 71% male, ISS 27, mortality 12%) who met inclusion criteria 27% (56/211) were overtransfused. Patients with a higher pre-hospital systolic blood pressure (112 vs 99 mmHg p < 0.01) and a higher initial haemoglobin concentration (132 vs 124 p = 0.02) were more likely to be overtransfused. Overtransfused patients received smaller volumes of packed red blood cells (5 vs 7 units p = 0.049), fresh frozen plasma (4 vs 6 units p < 0.01) and cryoprecipitate (6 vs 9 units p = 0.01) than non-overtransfused patients.

Conclusion
More than a quarter of patients in our cohort were potentially given more blood products than required without obvious clinical consequences. There were no clinically relevant associations with overtransfusion.
Intestinal eosinophils, homeostasis and response to bacterial intrusion
Authors: Gurtner Alessandra , Gonzalez-Perez Ignacio , Arnold Isabelle C. 
Published: April 2021

AbstractEosinophils are traditionally considered as end-stage effector cells involved in the pathogenesis of Th2 immune-mediated disorders as well as in the protection against parasite infection. However, this restricted view has recently been challenged by a series of studies revealing the highly plastic nature of these cells and implication in various homeostatic processes. Large numbers of eosinophils reside in the lamina propria of the gastrointestinal tract, at the front line of host defence, where they contribute to maintain the intestinal epithelial barrier function in the face of inflammation-associated epithelial cell damage. Eosinophils confer active protection against bacterial pathogens capable of penetrating the mucosal barrier through the release of cytotoxic compounds and the generation of extracellular DNA traps. Eosinophils also integrate tissue-specific cytokine signals such as IFN-γ, which synergise with bacterial recognition pathways to enforce different context-dependent functional responses, thereby ensuring a rapid adaptation to the ever-changing intestinal environment. The ability of eosinophils to regulate local immune responses and respond to microbial stimuli further supports the pivotal role of these cells in the maintenance of tissue homeostasis at the intestinal interface.
IoT-cloud based healthcare model for COVID-19 detection: an enhanced k-Nearest Neighbour classifier based approach
Authors: Mukherjee Rajendrani , Kundu Aurghyadip , Mukherjee Indrajit , Gupta Deepak , Tiwari Prayag , Khanna Ashish , Shorfuzzaman Mohammad 
Published: April 2021

AbstractCOVID - 19 affected severely worldwide. The pandemic has caused many causalities in a very short span. The IoT-cloud-based healthcare model requirement is utmost in this situation to provide a better decision in the covid-19 pandemic. In this paper, an attempt has been made to perform predictive analytics regarding the disease using a machine learning classifier. This research proposed an enhanced KNN (k NearestNeighbor) algorithm eKNN, which did not randomly choose the value of k. However, it used a mathematical function of the dataset’s sample size while determining the k value. The enhanced KNN algorithm eKNN has experimented on 7 benchmark COVID-19 datasets of different size, which has been gathered from standard data cloud of different countries (Brazil, Mexico, etc.). It appeared that the enhanced KNN classifier performs significantly better than ordinary KNN. The second research question augmented the enhanced KNN algorithm with feature selection using ACO (Ant Colony Optimization). Results indicated that the enhanced KNN classifier along with the feature selection mechanism performed way better than enhanced KNN without feature selection. This paper involves proposing an improved KNN attempting to find an optimal value of k and studying IoT-cloud-based COVID - 19 detection.
Firm Level Evidence of Disaster Impacts on Growth in Vietnam
Authors: Zhou Fujin , Botzen Wouter 
Published: April 2021

AbstractThe theory about the impacts of natural disasters on firms is ambiguous and the empirical evidence on this topic is scarce, which hampers the design of disaster risk reduction and climate change adaptation policies. In this paper we identify the short-run impacts of storms and floods on firm growth in labor, capital, and sales, using Enterprise Census data (2000–2014) for Vietnam. We define storms and floods with three different disaster measures: physical intensities, number of deaths, and economic damage. The performance of these disaster measures is compared by estimating dynamic growth models using the Blundell–Bond system generalized method of moments. We find evidence that flooding increases labor growth and capital growth but reduces sales growth significantly up to 3 years after flooding. We also find some evidence of positive impacts on labor growth and capital growth but mostly negative impacts on sales growth for storms within 3 years after storms strike. The impacts of floods and storms on firm growth are more pronounced and persistent for small and medium sized firms. Finally, unlike at the macro level, the direction and scale of disaster impacts found at the firm level are fairly consistent across the three disaster measures.
The assessment of the amount of water pollution and its suitability for drinking of the Tyśmienica River Basin, Poland
Authors: Grzywna Antoni , Sender Joanna 
Published: April 2021

AbstractThe quality and potability of waters of the Tyśmienica River Basin were determined in 2017 at eight measuring stations. The paper presents analyses of the physical and chemical parameters of surface waters of the basin. With regard to suspended solids, pH value, electric conductivity, sulphates, ammonia, chlorides and phosphate, the water was classified as having a very good ecological status. In the case of Kjeldahl nitrogen, the waters were classified as having a good ecological status. In the case of the remaining parameters, i.e. BOD, DO, TOC and COD, the status varied among stations. The values of all the physical and chemical parameters complied with the values for undisturbed conditions. Only ammonia and COD showed significant differences among stations. The WPI values for each measuring point ranged from 0.90 to 1.56, what corresponds to the descriptive indicators of moderately polluted water. The high concentrations of COD and TOC indicate that high-performance treatment processes (category A3) must be used to ensure that the water is suitable for drinking.
The Persian irrational performance beliefs inventory (iPBI-Persian): Translation, confirmatory factor analysis, and test–retest reliability, in Iranian athletes
Authors: Nejati Mohammadbagher , Farsi Alireza , Moteshareie Ebrahim , Turner Martin J. 
Published: April 2021

AbstractThis paper reports the development and initial validation of the Persian language Irrational Performance Beliefs Inventory (iPBI-Persian). The original iPBI was developed to provide a validated measure of the four core irrational beliefs of rational emotive behavior therapy (REBT) within performance-based samples, such as athletes. Data retrieved from 334 athletes (169 men, 165 women, Mage = 21.52 ± 4.00 years) were analyses using SPSS and LISREL software packages. After the linguistic and cross-cultural adaptation processes, confirmatory factor analysis (CFA) results showed that six items did not have acceptable factor loadings. After removal of problem items, a 22-item version was developed (CFI = 0.96). The iPBI-Persian demonstrated excellent levels of reliability, with internal consistency and test–retest reliability, as well as construct validity. This paper indicates that the 22-item iPBI-Persian can be used as a self-assessment instrument to evaluate irrational performance beliefs in Iranian athlete samples.
The Impact of Abortion Underreporting on Pregnancy Data and Related Research
Authors: Desai Sheila , Lindberg Laura D. , Maddow-Zimet Isaac , Kost Kathryn 
Published: April 2021

Abstract
Introduction
The impact on research findings that use pregnancy data from surveys with underreported abortions is not well-established. We estimate the percent of all pregnancies missing from women’s self-reported pregnancy histories because of abortion underreporting.

Methods
We obtained abortion and fetal loss data from the 2006–2015 National Survey of Family Growth (NSFG), annual counts of births from US vital statistics, and external abortion counts from the Guttmacher Institute. We estimated the completeness of abortion reporting in the NSFG as compared to the external counts, the proportion of pregnancies resolving in abortion, and the proportion of pregnancies missing in the NSFG due to missing abortions. Each measure was examined overall and by age, race/ethnicity, union status, and survey period.

Results
Fewer than half of abortions (40%, 95% CI 36–44) that occurred in the five calendar years preceding respondents’ interviews were reported in the NSFG. In 2006–2015, 18% of pregnancies resolved in abortion, with significant variation across demographic groups. Nearly 11% of pregnancies (95% CI 10–11) were missing from the 2006–2015 NSFG due to abortion underreporting. The extent of missing pregnancies varied across demographic groups and was highest among Black women and unmarried women (18% each); differences reflect both the patterns of abortion underreporting and the share of pregnancies ending in abortion.

Discussion
Incomplete reporting of pregnancy remains a fundamental shortcoming to the study of US fertility-related experiences. Efforts to improve abortion reporting are needed to strengthen the quality of pregnancy data to support maternal, child, and reproductive health research.
Aortic valve implantation-induced conduction block as a framework towards a uniform electrocardiographic definition of left bundle branch block
Authors: Calle S. , Coeman M. , Demolder A. , Philipsen T. , Kayaert P. , De Buyzere M. , Timmermans F. , De Pooter J. 
Published: April 2021

Abstract
Introduction
New-onset left bundle branch block (LBBB) following transcatheter or surgical aortic valve replacement (LBBBAVI) implies a proximal pathogenesis of LBBB. This study compares electrocardiographic characteristics and concordance with LBBB definitions between LBBBAVI and non-procedure-induced LBBB controls (LBBBcontrol).

Methods
All LBBBAVI patients at Ghent University Hospital between 2013 and 2019 were enrolled in the study. LBBBAVI patients were matched for age, sex, ischaemic heart disease and ejection fraction to LBBBcontrol patients in a 1:2 ratio. For inclusion, a non-strict LBBB definition was used (QRS duration ≥ 120 ms, QS or rS in V1, absence of Q waves in V5-6). Electrocardiograms were digitally analysed and classified according to three LBBB definitions: European Society of Cardiology (ESC), Strauss and American Heart Association (AHA).

Results
A total of 177 patients (59 LBBBAVI and 118 LBBBcontrol) were enrolled in the study. LBBBAVI patients had more lateral QRS notching/slurring (100% vs 85%, p = 0.001), included a higher percentage with a QRS duration ≥ 130 ms (98% vs 86%, p = 0.007) and had a less leftward oriented QRS axis (−15° vs −30°, p = 0.013) compared to the LBBBcontrol group. ESC and Strauss criteria were fulfilled in 100% and 95% of LBBBAVI patients, respectively, but only 18% met the AHA criteria. In LBBBcontrol patients, concordance with LBBB definitions was lower than in the LBBBAVI group: ESC 85% (p = 0.001), Strauss 68% (p < 0.001) and AHA 7% (p = 0.035). No differences in electrocardiographic characterisation or concordance with LBBB definitions were observed between LBBBAVI and LBBBcontrol patients with lateral QRS notching/slurring.

Conclusion
Non-uniformity exists among current LBBB definitions concerning the detection of proximal LBBB. LBBBAVI may provide a framework for more consensus on defining proximal LBBB.
Turbulence load prediction for manned and unmanned aircraft by means of anticipating differential pressure measurements
Authors: Galffy Andras , Gaggl Rainer , Mühlbacher Robert , Frank Daniel , Schlarp Johannes , Schitter Georg 
Published: April 2021

AbstractThis paper focuses on the prediction of disturbance effects of the vertical acceleration of an aircraft flying in atmospheric turbulence. To this end, 5-hole probes with high-dynamic differential pressure sensors are installed in front of a fixed-wing unmanned aircraft system (UAS) and a manned experimental aircraft to measure the local airspeed and angle of attack of the airflow. Test flights are performed in light, moderate and severe turbulence to assess the anticipating character and the accuracy of the predicted acceleration. Thereby, depending on the flown airspeed, anticipation times up to 0.1 s are observed. For the UAS the prediction accuracy is assessed to be 71.19% for moderate turbulence and 71.05% for severe turbulence, where vertical acceleration disturbances higher than 30 m/s2are measured. The first manned test flight revealed a prediction accuracy of 61.97%.
Molecular diagnosis of SARS-CoV-2 in seminal fluid
Authors: Paoli D. , Pallotti F. , Nigro G. , Mazzuti L. , Hirsch M. N. , Valli M. B. , Colangelo S. , Mastroianni C. M. , Antonelli G. , Lenzi A. , Turriziani O. , Lombardo F. 
Published: April 2021

Abstract
Purpose
Due to relevant repercussions on reproductive medicine, we aimed to evaluate feasibility of RT-PCR as a detection method of SARS-CoV-2 RNA in seminal fluid.

Methods
A qualitative determination of the RT-PCR assays in semen was performed through different approaches: (1) efficiency of RNA extraction from sperm and seminal plasma was determined using PRM1 and PRM2 mRNA and a heterologous system as control; (2) samples obtained by diluting viral preparation from a SARS-CoV-2 panel (virus cultured in Vero E6 cell lines) were tested; (3) viral presence in different fractions of seminal fluid (whole sample, seminal plasma and post-centrifugation pellet) was evaluated. Semen samples from mild and recovered COVID-19 subjects were collected by patients referring to the Infectious Disease Department of the Policlinico Umberto I Hospital - “Sapienza” University of Rome. Control subjects were recruited at the Laboratory of Seminology-Sperm Bank “Loredana Gandini'' of the same hospital.

Results
The control panel using viral preparations diluted in saline and seminal fluid showed the capability to detect viral RNA presence with Ct values depending on the initial viral concentration. All tested semen samples were negative for SARS-CoV-2, regardless of the nasopharyngeal swab result or seminal fluid fraction.

Conclusion
These preliminary data show that RT-PCR for SARS-CoV-2 RNA testing appears to be a feasible method for the molecular diagnosis of SARS-CoV-2 in seminal fluid, supported by results of the control panel. The ability to detect SARS-CoV-2 in semen is extremely important for reproductive medicine, especially in assisted reproductive technology and sperm cryopreservation.
Functions of parenting styles on patterns of general and serious delinquency trajectories: A mediated model of school climates and delinquent peer association
Authors: Cho Sujung , Nolasco Braaten Claire 
Published: April 2021

ABSTRACTIntroductionThis study partially tests Agnew’s (2005, 2011) general theory of crime and delinquency, drawing out the differential roles of parenting, constraints, and motivations when comparing general delinquency trajectories and serious delinquency trajectories.MethodsUsing data from a 7‐year follow‐up study of 927 South Korean male adolescents, the study incorporates a group‐based trajectory modeling to identify subgroups, each having a unique pattern of trajectories, respectively.ResultsThe models yielded 3 subgroups: Early onset & decreaser, Increaser & late peak, and Normative for general delinquency as well as Serious delinquent, Moderate delinquents, and Normative for serious delinquency. The results reveal that compared to Normative group, parenting styles were significant of both the Moderate and Serious delinquents groups for only serious delinquency even after controlling for constraints and motivations. The odds of belonging to both the Early‐Onset & Decreaser and Increaser & Late Peak groups for general delinquency and the Moderate Delinquents group for serious delinquency were significantly higher for those who more frequently associated with delinquent peers. Depression was significant among members of the Early‐Onset & Decreaser group, while school connectedness was significant among members of the Increaser & Late Peak group for general delinquency. There were no mediating role of constraints and motivations in the parent‐delinquency prediction.ConclusionsIntervention programs aimed at improving parenting skills can be developed to decrease the likelihood of delinquency.