bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frank O'Connor
Authors: Delaney Paul 
Published: February 2021

“O’Connor was, above all, a short story writer,” Maurice Sheehy proposed in the first extended bibliography of the writer’s work (Sheehy 1969, 168). Criticism over the last fifty years has generally endorsed this claim and has concentrated on O’Connor’s work as a practitioner and critic of the genre. Frank O’Connor (b. 1903–d. 1966) was the author of six volumes of short stories, the first of which, Guests of the Nation, appeared in 1931; his last volume, Domestic Relations, was published in 1957. He edited several collections of his own work, beginning with The Stories of Frank O’Connor in 1952, and additional collections were published posthumously; he was also the author of an influential study of short fiction, The Lonely Voice (1962) (see introduction to O’Connor as Short-Story Writer). Broadly speaking, O’Connor’s stories can be grouped into the following clusters: His stories of the 1930s engage with the fight for Irish independence and the subsequent disappointments of life in the newly emergent Free State; they also explore the uneasy relationship between traditional practices and modernizing values. His stories of the 1940s continue this concern with cultural clashes, intensifying the themes of frustration, provincialism, and loneliness, and dramatizing the power and the habitus of the Catholic Church in Ireland. In the late 1940s, O’Connor began writing for the New Yorker, and the impact of this magazine’s style can be seen in his short fiction of the 1950s and early 1960s; a number of stories from this period are narrated from the perspective of a child, many are nostalgic or whimsical, and some carry an autobiographical element. In addition to his short fiction, O’Connor was a novelist, dramatist, essayist, and literary critic; he had varying levels of success in each of these genres. Largely self-taught, he was fluent in Irish, and he was a distinguished translator of texts from the 7th and 8th centuries through to the modern period; his most famous translations include The Lament for Art O’Leary (1940) and The Midnight Court (1945). He was also a memoirist of note, and his first volume of autobiography, An Only Child (1961) is justly acclaimed. O’Connor wrote under the name “Frank O’Connor” throughout his life; this was a pseudonym of sorts, derived from his middle name (Francis) and his mother’s maiden name (O’Connor). His birth name was Michael O’Donovan.
The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role
Authors: Bertoletti Antonio , Tan Anthony T , Le Bert Nina 
Published: February 2021

Abstract
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), the etiological agent of Coronavirus Diseases 2019 (COVID-19), triggers an adaptive immunity in the infected host that results in the production of virus-specific antibodies and T cells. Although kinetic and quantitative aspects of antibodies have been analyzed in large patient cohorts, similar information about SARS-CoV-2-specific T cells are scarce. We summarize the available knowledge of quantitative and temporal features of the SARS-CoV-2 T-cell response in this review. Currently, most of the data are derived only from the analysis of the circulatory compartment. Despite this limitation, early appearance, multi-specificity and functionality of SARS-CoV-2-specific T cells are associated with accelerated viral clearance and with protection from severe COVID-19.
Genetic variation in the promoter of an R2R3−MYB transcription factor determines fruit malate content in apple (Malus domestica Borkh.)
Authors: Jia Dongjie , Wu Peng , Shen Fei , Li Wei , Zheng Xiaodong , Wang Yongzhang , Yuan Yongbing , Zhang Xinzhong , Han Zhenhai 
Published: February 2021

Abstract
Deciphering the mechanism of malate accumulation in apple (Malus domestica Borkh.) fruits can help to improve their flavor quality and enhance their benefits for human health. Here, we analyzed malate content as a quantitative trait that is determined mainly by genetic effects. In a previous study, we identified an R2R3−MYB transcription factor named MdMYB44 that was a candidate gene in qtl08.1 (quantitative trait locus mapped to chromosome 8) of fruit malate content. In the present study, we established that MdMYB44 negatively regulates fruit malate accumulation by repressing the promoter activity of the malate-associated genes Ma1 (Al-Activated Malate Transporter 9), Ma10 (P-type ATPase 10), MdVHA-A3 (V-type ATPase A3), and MdVHA-D2 (V-type ATPase D2). Two single-nucleotide polymorphisms (SNPs) in the MdMYB44 promoter, SNP A/G and SNP T/−, were experimentally shown to associate with fruit malate content. The TATA-box in the MdMYB44 promoter in the presence of SNP A enhances the basal activity of the MdMYB44 promoter. The binding of a basic-helix–loop–helix transcription factor MdbHLH49 to the MdMYB44 promoter was enhanced by the presence of SNP T, leading to increased MdMYB44 transcript levels and reduced malate accumulation. Furthermore, MdbHLH49 interacts with MdMYB44 and enhances MdMYB44 activity. The two SNPs could be used in combination to select for sour or non-sour apples, providing a valuable tool for the selection of fruit acidity by the apple breeding industry. This research is important for understanding the complex molecular mechanisms of fruit malate accumulation and accelerating the development of germplasm innovation in apple species and cultivars.
Reward Responsiveness in Patients with Opioid Use Disorder on Opioid Agonist Treatment: Role of Comorbid Chronic Pain
Authors: Finan Patrick H , Letzen Janelle , Epstein David H , Mun Chung Jung , Stull Samuel , Kowalczyk William J , Agage Daniel , Phillips Karran A , Pizzagalli Diego A , Preston Kenzie L 
Published: February 2021

AbstractObjectiveEvidence suggests that blunted reward responsiveness may account for poor clinical outcomes in both opioid use disorder (OUD) and chronic pain. Understanding how individuals with OUD and comorbid chronic pain (OUD+CP) respond to rewards is, therefore, of clinical interest because it may reveal a potential point of behavioral intervention.MethodsPatients with OUD (n = 28) and OUD+CP (n = 19) on opioid agonist treatment were compared on: 1) the Probabilistic Reward Task (an objective behavioral measure of reward response bias) and 2) ecological momentary assessment of affective responses to pleasurable events.ResultsBoth the OUD and the OUD+CP groups evidenced an increase in reward response bias in the Probabilistic Reward Task. The rate of change in response bias across blocks was statistically significant in the OUD group (B = 0.06, standard error [SE] = 0.02, t = 3.92, P &lt; 0.001, 95% confidence interval [CI]: 0.03 to 0.09) but not in the OUD+CP group (B = 0.03, SE = 0.02, t = 1.90, P = 0.07, 95% CI: −0.002 to 0.07). However, groups did not significantly differ in the rate of change in response bias across blocks (B = 0.03, SE = 0.02, t = 1.21, P = 0.23, 95% CI: −0.02 to 0.07). Groups did not significantly differ on state measures of reward responsiveness (P’s ≥0.50).ConclusionsOverall, findings across objective and subjective measures were mixed, necessitating follow-up with a larger sample. The results suggest that although there is a reward response bias in patients with OUD+CP treated with opioid agonist treatment relative to patients with OUD without CP, it is modest and does not appear to translate into patients’ responses to rewarding events as they unfold in daily life.
The Space of Traces in Symmetric Monoidal Infinity Categories
Authors: Steinebrunner Jan 
Published: February 2021

Abstract
We define a tracelike transformation to be a natural family of conjugation invariant maps $T_{x,\mathtt{C}}:\hom_\mathtt{C}(x, x) \to \hom_\mathtt{C}(&#x1D7D9;,&#x1D7D9;)$ for all dualizable objects x in any symmetric monoidal $\infty$-category $\mathtt{C}$. This generalizes the trace from linear algebra that assigns a scalar $\operatorname{Tr}(\,f\,) \in k$ to any endomorphism f : V → V of a finite-dimensional k-vector space. Our main theorem computes the moduli space of tracelike transformations using the one-dimensional cobordism hypothesis with singularities. As a consequence, we show that the trace $\operatorname{Tr}$ can be uniquely extended to a tracelike transformation up to a contractible space of choices. This allows us to give several model-independent characterizations of the $\infty$-categorical trace. By restricting the aforementioned notion of tracelike transformations from endomorphisms to automorphisms one can in particular recover a theorem of Toën and Vezzosi. Other examples of tracelike transformations are for instance given by $f \mapsto \operatorname{Tr}(\,f^{\,n})$. Unlike for $\operatorname{Tr}$, the relevant connected component of the moduli space is not contractible, but rather equivalent to $B\mathbb{Z}/n\mathbb{Z}$ or BS1 for n = 0. As a result, we obtain a $\mathbb{Z}/n\mathbb{Z}$-action on $\operatorname{Tr}(\,f^{\,n})$ as well as a circle action on $\operatorname{Tr}(\operatorname{id}_x)$.
Incentivising biodiversity net gain with an offset market
Authors: Simpson Katherine , Hanley Nick , Armsworth Paul , de Vries Frans , Dallimer Martin 
Published: February 2021

Abstract
Most programmes that incentivise the supply of public goods such as biodiversity conservation on private land in Europe are financed through the public purse. However, new ideas for how to fund biodiversity conservation are urgently needed, given recent reviews of the poor state of global biodiversity. In this paper, we investigate the use of private funding for biodiversity conservation through an offset market. The environmental objective is to increase some measure of biodiversity in a region (‘net gain’) despite the loss of land for new housing. Farmers create biodiversity credits by changing their land management and then sell these credits to housing developers who are required to more than offset the impacts of new housing development on a specific indicator of biodiversity. Combining an economic model of market operation with an ecological model linking land management to bird populations, we examine the operation, costs, and biodiversity impacts of such a (hypothetical) market as the target level of net gain is increased. A general result is established for the impacts on price and quantity in the offset market as the net gain target is made more ambitious. For a case-study site in Scotland, we find that as the net gain target is increased, the number of offsets traded in equilibrium falls, as does the market-clearing offset price. Changes in the spatial pattern of gains and losses in our biodiversity index also occur as the net gain target is raised.
‘It is good to have a target in mind’: qualitative views of patients and parents informing a treat to target clinical trial in juvenile-onset systemic lupus erythematosus
Authors: Smith Eve M D , Gorst Sarah L , Al-Abadi Eslam , Hawley Daniel P , Leone Valentina , Pilkington Clarissa , Ramanan Athimalaipet V , Rangaraj Satyapal , Sridhar Arani , Beresford Michael W , Young Bridget 
Published: February 2021

Abstract

Objective
We sought to explore patient and parental views on treatment targets, outcome measures and study designs being considered for a future JSLE treat-to-target (T2T) study.

Methods
We conducted topic-guided, semistructured interviews with JSLE patients and parents and analysed the audio recorded interviews using thematic approaches.

Results
Patients and parents differed regarding symptoms they felt would be tolerable, representing ‘low disease activity’. Patients often classed symptoms that they had previously experienced, were ‘invisible’ or had minimal disruption on their life as signs of low disease activity. Parents were more accepting of visible signs but were concerned about potential organ involvement and symptom severity. Overall, patients and parents preferred that children were entirely asymptomatic, with no ongoing treatment side effects. They regarded fatigue as particularly challenging, requiring proper monitoring using a fatigue patient-reported outcome measure. Most families felt that reducing corticosteroids would also be a good treatment target. Overall, families liked the concept of T2T, commenting that it could help to improve disease control, help structure treatment and improve communication with clinicians and treatment compliance. They were concerned that T2T might increase the frequency of hospital visits, thus impacting upon schooling, parental employment and finances. Families made suggestions on how to modify the future trial design to mitigate such effects.

Conclusion
This study provides guidance from patients and parents on T2T targets and study designs. Complementary quantitative studies assessing the achievability and impact of different targets (e.g. lupus low disease activity state or remission) are now warranted to inform an international consensus process to develop treatment targets.
Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia
Authors: Dauvermann Maria R , Mothersill David , Rokita Karolina I , King Sinead , Holleran Laurena , Kane Ruan , McKernan Declan P , Kelly John P , Morris Derek W , Corvin Aiden , Hallahan Brian , McDonald Colm , Donohoe Gary 
Published: February 2021

Abstract

Background
There is considerable evidence of dysconnectivity within the default-mode network (DMN) in schizophrenia, as measured during resting-state functional MRI (rs-fMRI). History of childhood trauma (CT) is observed at a higher frequency in schizophrenia than in the general population, but its relationship to DMN functional connectivity has yet to be investigated.

Methods
CT history and rs-fMRI data were collected in 65 individuals with schizophrenia and 132 healthy controls. Seed-based functional connectivity between each of 4 a priori defined seeds of the DMN (medial prefrontal cortex, right and left lateral parietal lobes, and the posterior cingulate cortex) and all other voxels of the brain were compared across groups. Effects of CT on functional connectivity were examined using multiple regression analyses. Where significant associations were observed, regression analyses were further used to determine whether variance in behavioral measures of Theory of Mind (ToM), previously associated with DMN recruitment, were explained by these associations.

Results
Seed-based analyses revealed evidence of widespread reductions in functional connectivity in patients vs controls, including between the left/right parietal lobe (LP) and multiple other regions, including the parietal operculum bilaterally. Across all subjects, increased CT scores were associated with reduced prefrontal-parietal connectivity and, in patients, with increased prefrontal-cerebellar connectivity also. These CT-associated differences in DMN connectivity also predicted variation in behavioral measures of ToM.

Conclusions
These findings suggest that CT history is associated with variation in DMN connectivity during rs-fMRI in patients with schizophrenia and healthy participants, which may partly mediate associations observed between early life adversity and cognitive performance.
Candidate Factors Maintaining Social Anxiety in the Context of Psychotic Experiences: A Systematic Review
Authors: Aunjitsakul Warut , McGuire Nicola , McLeod Hamish J , Gumley Andrew 
Published: February 2021

AbstractSocial anxiety is common in psychosis and associated with impaired functioning, poorer quality of life, and higher symptom severity. This study systematically reviewed factors maintaining social anxiety in people with attenuated, transient, or persistent psychotic experiences. Other correlates of social anxiety were also examined. MEDLINE, Embase, CENTRAL, and PsycINFO were searched for relevant literature up to October 19, 2020. Forty-eight articles were eligible for narrative synthesis: 38 cross-sectional studies, 8 prospective studies, 1 uncontrolled trial, and 1 qualitative study. From 12060 participants, the majority was general population (n = 8771), followed by psychosis samples (n = 2532) and those at high risk of psychosis (n = 757). The methodological quality and risk of bias were assessed using the Mixed Methods Appraisal Tool. Ninety percent of studies were rated as high to very-high quality. Poorer quality studies typically failed to adequately control for confounds and provided insufficient information on the measurement validity and reliability. Prominent psychological factors maintaining social anxiety included self-perceptions of stigma and shame. Common correlates of social anxiety included poorer functioning and lower quality of life. In conclusion, stigma and shame could be targeted as a causal mechanism in future interventional studies. The integration of findings from this review lead us to propose a new theoretical model to guide future intervention research.
Efficacy and Safety of Levetiracetam vs. Phenytoin as Second Line Antiseizure Medication for Pediatric Convulsive Status Epilepticus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Angurana Suresh Kumar , Suthar Renu 
Published: February 2021

Abstract

Objective
To evaluate the efficacy and safety of levetiracetam (LEV) in comparison to phenytoin (PHT) as second line antiseizure medication (ASM) for Pediatric convulsive status epilepticus (SE).

Data source
PubMed, Embase, Google scholar/Google, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials.

Study selection
Randomized controlled trials (RCTs) assessing LEV and PHT as second line agent for convulsive SE in children &lt;18 years published between 1 January 2000 and 30 November 2020.

Data extraction
The data were pooled regarding the proportion of children achieving seizure cessation within 5–60 min of completion of study drug infusion (primary outcome); and seizure cessation within 5 min, time to achieve seizure cessation, seizure recurrence between 1 to 24 h, intubation and cardiovascular instability (secondary outcomes). Data were analyzed using RevMan version 5.4 and quality analysis was done using Cochrane risk-of-bias tool. The study protocol was registered with PROSPERO.

Data synthesis
Twelve RCTs with 2293 children were included. Seizure cessation within 5–60 min was similar with both the drugs [82% in LEV vs. 77.5% in PHT, risk ratio (RR) = 1.04, 95% confidence interval (95% CI) 0.97–1.11, p = 0.30]. Seizure recurrences within 1–24 h was higher with PHT in comparison to LEV (16.6% vs. 9.7%, RR = 0.63, 95% CI 0.44–0.90, p = 0.01). Higher proportion of children in PHT group required intubation and mechanical ventilation (21.4% vs. 14.2%, RR = 0.54, 95% CI 0.30–0.98, p = 0.04). Seizure cessation within 5 min, time to achieve seizure cessation, and cardiovascular instability were similar with both the drugs. Three RCTs were at low risk of bias and nine were at high risk of bias.

Conclusion
The efficacy of LEV is similar to PHT as second line ASM for Pediatric convulsive SE. Seizure recurrences between 1 to24 h and requirement of intubation and mechanical ventilation were significantly higher with PHT in comparison to LEV.
Effect of medications after cardiac surgery on long-term outcomes in patients with cirrhosis
Authors: Chou An-Hsun , Lin Yu-Sheng , Wu Victor Chien-Chia , Chen Fang-Ting , Yang Chia-Hung , Chen Dong-Yi , Chen Shao-Wei 
Published: February 2021

Abstract
The aim of this study was to evaluate the effect of beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) after cardiac surgery in the liver cirrhosis (LC) patients. We conducted a population-based cohort study using data from the Taiwanese National Health Insurance Research Database (NHIRD) from 2001 to 2013. The outcomes of interest included all-cause mortality, major adverse cardiac and cerebrovascular events (MACCE) and liver and renal outcomes. Among 1470 LC patients, 35.6% (n = 524) received beta-blockers and 33.4% (n = 491) were prescribed ACEIs and/or ARBs after cardiac surgery. The risk of negative liver outcomes was significantly lower in the ARB group compared with the ACEI group (9.6% vs 22.7%, hazard ratio [HR] 0.50, 95% confidence interval [CI] 0.31–0.83). Furthermore, the risk of MACCE (44.2% vs 54.7%, HR 0.79, 95% CI 0.65–0.96), all-cause mortality (35.3% vs 46.4%, HR 0.74, 95% CI 0.60–0.92), composite liver outcomes (9.6% vs 16.5%, HR 0.56, 95% CI 0.38–0.85) and hepatic encephalopathy (2.7% vs 5.7%, HR 0.45, 95% CI 0.21–0.94) were lower in the ARB group than the control group. Our study demonstrated that ARBs provide a greater protective effect than ACEIs in regard to long-term outcomes following cardiac surgery in patients with LC.
Efficacy and safety of traditional Chinese herbal medicine in the treatment of threatened abortion
Authors: Zeng Pengfei , Zhou Hang , Guo Pei , Xia Wanting , Huang Jinzhu , Zeng Qian 
Published: February 2021

Abstract

Background:
Threatened abortion (TA) is the commonest complication that occurs in early pregnancy, especially in 8-12 gestational weeks when the secretion of estrogen and progesterone shifts from corpus luteum to placental. Conventional therapies are little evidence of their value. In China, traditional Chinese herbal medicine has been widely used for the treatment of TA for a long time. The lack of strong scientific evidences make this a priority area for research. We aim to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment of TA, provide medical staffs with more useful information, and provide patients with better advises.

Methods:
We will search 8 databases and additional sources, including the Web of Science, PubMed, Cochrane Library, Embase, CBM, Wanfang, VIP, CNKI, and WHO ICTRP, ChiCTR, Clinical Trials, Grey Literature Database, for potentially eligible studies. Literature search, screening and retrieval are performed independently by two researchers. In the event of a dispute, a third party will be consulted to support the judgment. We will use RevmanV.5.3 to perform a fixed-effect meta-analysis for clinical homogeneity study data, and the level of evidence will be assessed using the GRADE method.

Results:
This systematic review and meta-analysis will put a high-quality synthesis of the efficacy and safety of traditional Chinese herbal medicine in the treatment of TA.

Conclusion:
The conclusion of this systematic review will provide evidence to assess traditional Chinese herbal medicine therapy whether is an efficacy and safe intervention to treat TA.

Ethics and dissemination:
Since this article does not contain patient personal information, ethical approval is not required. The contract is distributed by a peer-reviewed journal or conference report.

Registration number:
10.17605/OSF.IO/DG3T8