bluuebunny/crossref_metadata_2025_split huggingface dataset:
Black empowerment and Afro-American values in Toni Morrison’s The Bluest Eye
Authors: Karim Sajjadul , Idrus Mohd Muzhafar Bin 
Published: March 2021

The Bluest Eye of Toni Morrison is extraordinarily significant, as it addresses the different sides of American literature, and the lives of the Afro-American people. Although the conventional theological aspects of white culture can negatively influence other characters of Morrison, it is Pecola whose life appears to be increasingly defenseless against the impulses of the individuals who have accepted the Western custom. In a democratic country, people generally have the same value, but there are still prejudices in the concepts of beauty and worthiness. The search for freedom, black identity, the nature of evil and the robust voices of African-Americans have become themes for African-American literature. Folklore covers the history of black and white interaction in the United States and also summarizes the feelings expressed in protest literature1. Morrison argues that the survival of the dark ladies in a white dominated society depends on loving their own way of life and dark race and rejecting the models of white culture or white excellence. This article attempts to examine The Bluest Eye from the perspective of empowerment of blacks and African American and their value system.
IIUC Studies Vol.16, December 2019: 111-121
Tetanus Toxoid Vaccination Status of Women of child bearing age in Rangamati Pourashava
Authors: Nazneen Nazia , Alam Mohammed Nurul , Akhter Most Dalia , Rahman Md Shamsur , Parveen Mukta , Begum Arifa 
Published: March 2021

Tetanus Toxoid (TT) is a routine vaccination activity under Expanded Program on Immunization (EPI) in Bangladesh. This was a descriptive type of cross-sectional study with a sample size of 110, selected purposively by non-probability sampling technique. Data were collected through a pretested questionnaire. The aim of this study was to assess TT vaccination coverage among the women of child bearing age, Rangamati Pourashava. As per survey, among 110 respondents, 29 (26.4%) were of 15-25 years, 52 (47.3%) were of 26-35 years, 25(22.7%) were of 36-45 years & only 4(3.6%) were of >45years. In this study, the major group, 86(78.2%) were married, 17(15.4%) were unmarried & only 7 (6.4%) were widow. Most of the respondents considered vaccination as the way of disease prevention, so that the coverage being 92 (83.6%) in case of TT vaccination. It was found that 70% women received TT vaccine from Government EPI centers followed by 23.6% from NGO facilities and only6.4% from private clinics. Among the respondents, 56.3% respondents had completed their dose schedule of TT vaccine respectively. Most of the respondents had their vaccination card. The percentage was 70 for TT respectively. Among others, 20% failed to follow it because of forgetfulness of doses and 3.34% because of losing their card. So, TT vaccination coverage among the women of child bearing age was satisfactory but it also suggests that more awareness campaign for vaccination is sensational among the mass people of our country. This study TT vaccination status among women of child bearing age will help to get idea about the woman of our country regarding the situation.
Mediscope Vol. 8, No. 1: January 2021, Page 40-44
Bone Marrow Granuloma with Miliary Mottling presenting as Pancytopenia- A rare finding in Tuberculosis - A Case report
Authors: Momin Majed Abdul Basit , Singh Rahul Dev , C Ugandhar Bhattu , G Krishna Mohan Reddy 
Published: March 2021

Bone marrow granuloma and miliary mottling presenting as pancytopenia together is a rare finding in disseminated form of tuberculosis. Here we report a case of a 52-year, old male patient presented with generalized weakness, loss of appetite, decreased physical activity for one month. Initial lab hematological investigations revealed pancytopenia and high Erythrocyte sedimentation rate. Bone marrow biopsy was performed to determine the cause of pancytopenia which showed caseating granulomas with positive acid fast bacilli on Ziehl-Neelsen staining (Z-N). In chest X-ray miliary mottling and bone marrow biopsy findings together confirmed the case of disseminated tuberculosis. This unusual presentation highlights the considerable diagnostic challenge and importance of bone marrow biopsy for early diagnosis and initiation of treatment.
Mediscope Vol. 8, No. 1: January 2021, Page 63-66
Gestión administrativa y desempeño laboral en una entidad educativa de Arequipa en la coyuntura de COVID-19
Authors: Fernandez Sanchez Diego Gonzalo 
Published: March 2021

El propósito de la presente investigación fue definir la relación existente entre las variables de gestión administrativa y el desempeño laboral en docentes de la Institución Educativa “Andenes de Chilina”, Arequipa, 2020. Metodológicamente, es una investigación de tipo pura, también conocida como fundamental. El nivel de investigación fue correlacional, donde se determinó la relación entre las dos variables objeto de estudio. Se trabajó bajo el método hipotético-deductivo con enfoque cuantitativo y de corte transversal, debido a que se realizó la medición una sola vez en el tiempo. Se contó con una población muestral de 28 docentes de ambos sexos, los cuales se encuentran dentro de los niveles educativos básicos (inicial, primaria y secundaria). En los resultados obtenidos, según la prueba estadística de correlación de Pearson aplicado a nuestras variables en estudio: gestión administrativa y desempeño laboral, se consiguió un r = 0.834 (correlación positiva alta) con un nivel 0.000 de significancia, el cual fue menor que el valor esperado (p < 0.05). Fue por esta razón que se aceptó la hipótesis alterna, rechazando la hipótesis nula formulada. Se concluyó que existe una relación positiva y significativa entre gestión administrativa y desempeño laboral docente en la Institución Educativa “Andenes de Chilina”,Arequipa, 2020.
Pengaruh Pengetahuan Tentang Dampak Gadget Pada Kesehatan Terhadap Perilaku Penggunaan Gadget Pada Siswa SDN Kebun Bunga 6 Banjarmasin
Authors: Anggraeni Septi 
Published: March 2021

Kemajuan zaman di bidang ilmu teknologi semakin berkembang. Teknologi yang sangat popular di era globalisasi ini adalah gadget. Penggunaan gadget pada anak semakin meningkat. Akademi Dokter Anak Amerika dan Perhimpunan Dokter Anak Kanada menegaskan perlu adanya batasan dalam penggunaan teknologi pada anak, anak umur 6-18 tahun dibatasi menggunakan hanya 2 jam perhari. Anak-anak dan remaja yang menggunakan teknologi melebihi batas waktu yang dianjurkan memiliki resiko kesehatan. Kurangnya pemahaman tentang dampak penggunaan gadget menjadikan anak berperilaku menggunakannya secara berlebihan. Tujuan penelitian ini adalah untuk mengetahui pengaruh pengetahuan tentang dampak gadget pada kesehatan terhadap perilaku penggunaan gadget pada siswa SDN Kebun Bunga 6 Banjarmasin. Penelitian ini merupakan penelitian survey analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh siswa kelas VI SDN Kebun Bunga 6 Banjarmasin. Sampel pada penelitian ini adalah total dari populasi yaitu sebanyak 50 siswa. Hasil analisis Regresi Linear sederhana menunjukkan adanya pengaruh pengetahuan tentang dampak gadget pada kesehatan terhadap perilaku penggunaan gadget pada siswa (p value = 0,002) dengan besar pengaruh 18,9%. Dalam hal ini perlu adanya peningkatan pengetahuan siswa tentang dampak gadget pada kesehatan, karena semakin tinggi pengetahuan akan dikuti dengan penurunan perilaku penggunaan gadget.
Fenomena tentang Pengetahuan, Ketersediaan Fasilitas (Availabilitas), dan Dukungan Istri Terkait dengan Perilaku Pria dalam Ber-KB Di Wilayak KerjaPuskesmas Ciruas, Kabupaten Serang Tahun 2019
Authors: Khotimah Husnul 
Published: March 2021

Program Keluarga Berencana (KB) merupakan salah satu cara yang dapat ditempuh oleh pemerintah dalam mengatasi permasalahan kependudukan. Upaya untuk mengurangi angka kelahiran, bukan semata tanggung jawab isteri, melainkan tanggung jawab suami. Partisipasi pria dalam ber KB maka merupakan faktor penentu keberhasilan program KB. Penelitian ini bertujuan untuk mengetahui fenomena yang terjadi di masyarakat terkait prilaku pria dalam ber-KB di Wilayah Kerja Puskesmas Ciruas Kabupaten Serang Tahun 2019. Metode penelitian menggunakan pendekatan fenomenologis dengan cara observasi dan wawancara mendalam terkait pengetahuan pria tentang KB, ketersediaan fasilitas dan dukungan isteri terhadap KB pria. Teknik analis data yang digunakan dalam penelitian ini adalah analisis data induktif dengan cara menalaah data, reduksi data, kategorisasi display data dan yang terakhir adalah kesimpulan. Hasil penelitian menunjukkan semua informan memiliki pengetahuan kurang mengenai KB pria, sebagian informan tidak mendapat dukungan isteri, dan sebagian informan menganggap KB pria tidak tersedia. Pengetahuan, dukungan isteri dan ketersediaan fasilitas mempengaruhi prilaku pria dalam ber-KB.
Hubungan Pengetahuan dan Sikap Pelajar Dengan Upaya Pencegahan HIV/AIDS di SMA Negeri 2 Raha, Kabupaten Muna
Authors: Rangki La , Firtiani Firtiani 
Published: March 2021

Tingginya kasus infeksi HIV/AIDS yang terus bertambah terutama dari kalangan usia muda atau remaja merupakan permasalahan yang serius. Kurangnya pengetahuan dan sikap remaja tentang HIV/AIDS dapat memengaruhi tindakan pencegahan terhadap HIV/AIDS. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan dan sikap siswa dengan upaya pencegahan HIV/AIDS. Jenis penelitian yang di gunakan adalah observasional analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah siswa kelas 1 dan 2 SMA Negeri 2 Raha. Pengambilan sampel dalam penelitian ini menggunakan metode stratified random sampling dengan jumlah 87 responden. Hasil penelitian menunjukan bahwa sebagian besar responden memiliki pengetahuan baik sejumlah 63 siswa (72,4%) dan sebagian kecil responden memiliki pengetahuan kurang sejumlah 24 siswa (27,6%). Hampir seluruh responden memilki sikap mendukung yaitu 86 siswa (98,9%), dan hanya 1 siswa (1,1%) yang tidak mendukung. Dalam upaya pencegahan, hanya 2 siswa (2,3 %) yang tidak melakukan sedangkan hamper seluruh responden yaitu 85 siswa (97,7%) melakukan. Tidak ada hubungan yang bermakna antara pengetahuan siswa dengan supaya pencegahan HIV/AIDS di SMA Negeri 2 Raha, tetapi terdapat hubungan yang bermakna antara sikap siswa terhadap upaya pencegahan HIV/AIDS. Disarankan kepada siswa-siswi agar lebih bisa menyaring informasi yang di dapatkan, sehingga terbentuk pola sikap yang positif dalam pencegahan HIV/AIDS.
Kepemilikan Jamban Sehat Pada Masyarakat
Authors: Mukhlasin Mukhlasin , Solihudin Encep Nugraha 
Published: March 2021

Penggunaan jamban leher angsa pada masyarakat di desa Walikukun Kecamatan Carenang Kabupaten Serang sebanyak Desa Walikukun 50,36%, pengguna. Tujuan Penelitian ini adalah mengetahui ketersediaan air bersih, ketersediaan lahan, dan pendapatan yang berhubungan dengan kepemilikan jamban pada masyarakat di Desa Walikukun Kecamatan Carenang Kabupaten Serang Tahun 2020. Metode dalam penelitian ini menggunakan desain crossectional. Jumlah Responden pada penelitian ini sebanyak 87 responden. Teknik pengambilan sampel dengan menggunakan simple random sampling dengan analisis bivariat menggunakan Chi square test. Hasil penelitian menunjukkan bahwa semua variabel berhubungan dengan kepemilikan jamban di Desa Walikukun Kecamatan Carenang; ketersediaan air bersih (pv=0,000; OR=117,8), ketersediaan lahan (pv=0,000), variabel pendapatan (pv=0,000). Penelitian ini menyimpulkan bahwa sebagian besar masyarakat (68,8%) tidak memiliki jamban.
Pengaruh Latihan Peregangan Perut Terhadap Karakteristik Nyeri Menstruasi Remaja Awal
Authors: Saifah Andi 
Published: March 2021

Nyeri menstruasi cenderung mengganggu aktifitas sehari-hari dan penampilan akademik pada remaja putri. Latihan peregangan merupakan salah satu intervensi nonfarmakologi dalam mengatasi nyeri. Tujuan penelitian adalah menganalisis pengaruh latihan peregangan perut terhadap perubahan karakteristik nyeri menstruasi remaja awal di SMP Negeri Kecamatan Tatanga Kota Palu. Desain penelitian yang digunakan adalah quasi experimental pre-test dan post test design. Pengambilan sampel secara purposive sampling, masing-masing 41 responden (usia 12-14 tahun dengan nyeri menstruasi) untuk kelompok perlakuan dan kelompok kontrol. Instrument penelitian adalah kuesioner, checklist karakteristik nyeri menstruasi dan booklet panduan latihan. Uji statistik yang digunakan adalah uji Wilcoxon dengan tingkat kemaknaan 95%. Hasil uji Wilcoxon menunjukkan perbedaan bermakna antara durasi dan radiasi nyeri menstruasi sebelum dan setelah latihan peregangan perut. Tidak ada perbedaan bermakna pada irama dan kualitas nyeri menstruasi (ρ>0,05). Kesimpulan penelitian adalah latihan peregangan perut mempengaruhi penurunan durasi dan radiasi nyeri menstruasi, namun belum berefek maksimal terhadap penurunan irama dan kualitas nyeri menstruasi.
Hubungan antara Grade Hipertensi dengan Tingkat Kemandirian Lansia dalam Activities Of Daily Living (ADLs)
Authors: Darmawati Irma , Kurniawan Febri Andri 
Published: March 2021

Prevalensi hipertensi di Indonesia semakin meningkat setiap tahun terutama pada kelompok lansia. Penurunan tingkat kemandirian lansia akibat hipertensi menjadi perhatian utama dalam rangka pencapaian kualitas hidup yang optimal. Tujuan penelitian ini adalah untuk mengetahui hubungan antara derajat hipertensi pada lansia dengan tingkat kemandirian dalam menjalankan aktivitas sehari-hari. Pengambilan sampel dilakukan secara cluster sampling berjumlah 49 lansia hipertensi. Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross sectional. Analisa hubungan variabel grade hipertensi dan tingkat kemandirian menggunakan analisis korelasi spearman rank. Hasil penelitian menunjukan 55,1% lansia mengalami hipertensi grade II dan 49% lansia mengalami ketergantungan sebagian. Berdasarkan analisa korelasi spearman rank di dapatkan hasil p value 0,000 (<0,05) dan r -0,56 dengan kesimpulan terdapat hubungan yang cukup kuat antara penyakit hipertensi dengan kemandirian lansia, dengan arah hubungan yang negatif artinya semakin tinggi tekanan darah maka semakin rendah kemandirian lansia. Perubahan tingkat kemandirian lansia yang diakibatkan oleh hipertensi ini seyogyanya menjadi perhatian perawat agar selalu melakukan monitoring grade hipertensi pada lansia secara rutin setiap bulan. Keterlibatan keluarga ditingkatkan untuk memberikan dukungan keluarga yang dapat membantu lansia agar kualitas hidup lansia hipertensi tetap dapat tercapai secara optimal.
3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo
Authors: Fu Xiaorong , Zhao Ran , Yoon Goo , Shim Jung-Hyun , Choi Bu Young , Yin Fanxiang , Xu Beibei , Laster Kyle Vaughn , Liu Kangdong , Dong Zigang , Lee Mee-Hyun 
Published: March 2021

BackgroundSkin cancer is one of the most commonly diagnosed cancers worldwide. The 5-year survival rate of the most aggressive late-stage skin cancer ranges between 20 and 30%. Thus, the discovery and investigation of novel target therapeutic agents that can effectively treat skin cancer is of the utmost importance. The T-lymphokine-activated killer cell-originated protein kinase (TOPK), which belongs to the serine-threonine kinase class of the mitogen-activated protein kinase kinase (MAPKK) family, is highly expressed and activated in skin cancer. The present study investigates the role of 3-deoxysappanchalcone (3-DSC), a plant-derived functional TOPK inhibitor, in suppressing skin cancer cell growth.PurposeIn the context of skin cancer prevention and therapy, we clarify the effect and mechanism of 3-DSC on different types of skin cancer and solar-simulated light (SSL)-induced skin hyperplasia.MethodsIn anin vitrostudy, western blotting andin vitrokinase assays were utilized to determine the protein expression of TOPK and its activity, respectively. Pull-down assay with 3-DSC and TOPK (wild-type and T42A/N172 mutation) was performed to confirm the direct interaction between T42A/N172 amino acid sites of TOPK and 3-DSC. Cell proliferation and anchorage-independent cell growth assays were utilized to determine the effect of 3-DSC on cell growth. In anin vivostudy, the thickness of skin and tumor size were measured in the acute SSL-induced inflammation mouse model or SK-MEL-2 cell-derived xenografts mouse model treated with 3-DSC. Immunohistochemistry analysis of tumors isolated from SK-MEL-2 cell-derived xenografts was performed to determine whether cell-based results observed upon 3-DSC treatment could be recapitulatedin vivo.Results3-DSC is able to inhibit cell proliferation in skin cancer cells in an anchorage-dependent and anchorage-independent manner by regulation of TOPK and its related signaling pathwayin vitro. We also found that application of 3-DSC reduced acute SSL-induced murine skin hyperplasia. Additionally, we observed that 3-DSC decreased SK-MEL-2 cell-derived xenograft tumor growth through attenuating phosphorylation of TOPK and its downstream effectors including ERK, RSK, and c-Jun.ConclusionsOur results suggest that 3-DSC may function in a chemopreventive and chemotherapeutic capacity by protecting against UV-induced skin hyperplasia and inhibiting tumor cell growth by attenuating TOPK signaling, respectively.
Effects of Stationary and Transient Transport of Ozone on the Ozone Valley Over the Tibetan Plateau in Summer
Authors: Xu Wenwen , Song Qianqian , Li Yajuan , Shi Chunhua , Sun Bo , Su Yucheng , Tang Zhou , Du Yahan , Guo Dong 
Published: March 2021

We studied the effects of the stationary and transient transport of ozone in the upper troposphere and lower stratosphere (UTLS) on the ozone valley over the Tibetan Plateau (OVTP) in summer using the daily ERA-Interim reanalysis dataset for the time period 1979–2016. We used the Lorenz circulation decomposition method to separate the stationary and transient transport of ozone into terms related to either the mean flow or eddies. The decrease in the total ozone concentration in summer is associated with the transport of ozone, which, in turn, reinforces the OVTP. The zonal (meridional) transport of ozone, which combines stationary and transient transport, strengthens (weakens) the ozone valley. The stationary zonal (meridional) transport of ozone strengthens (weakens) the ozone valley. The transient zonal (meridional) transport of ozone weakens (strengthens) the ozone valley, but this effect is weaker than that of stationary transport. The mean flow has the dominant role, especially in the stationary component. The effect of eddies on the zonal transient transport of ozone is as strong as that of the mean flow. For stationary transport, the zonal deviation of ozone transported by the zonal mean flow in the zonal (meridional) direction C(O3∗¯ [u]¯)(C(O3∗¯ [v]¯)) dominates total zonal (meridional) change of ozone C(O3¯ u¯)(C(O3¯ v¯)), which strengthens (weakens) the ozone valley. The transient transport of the zonal mean ozone by eddies (C([O3]′u∗′¯)), the zonal deviation of ozone by the zonal mean flow (C(O3∗′[u]′¯)) and the zonal deviation of ozone by eddies (C(O3∗′u∗′¯)) all have a strong effect on the ozone valley. By contrast, the transient transport of the zonal mean ozone by eddies in the meridional direction (C([O3]′v∗′¯)) has a much weaker and the smallest effect. Both the zonal deviation of ozone by the zonal mean flow and by eddies in the meridional direction (C(O3∗′[v]′¯) and  C(O3∗′v∗′¯)) have major roles in transient meridional transport, but their roles are the opposite of each other. The contributions of stationary and transient transport to zonal transport are consistent, whereas their contributions to meridional transport are the opposite of each other. The influence of transient transport on the formation and maintenance of OVTP is not negligible.
Genetic Variants in TNFSF4 and TNFSF8 Are Associated With the Risk of HCV Infection Among Chinese High-Risk Population
Authors: Fu Zuqiang , Cai Weihua , Shao Jianguo , Xue Hong , Ge Zhijun , Fan Haozhi , Dong Chen , Wang Chunhui , Zhang Jinwei , Shen Chao , Zhang Yun , Huang Peng , Yue Ming 
Published: March 2021

BackgroundThe tumor necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) play important roles in the immune responses to infections. The aim of this study was to determine the impact of single nucleotide polymorphisms (SNPs) of several TNFSF/TNFRSF genes on the risk of hepatitis C virus (HCV) infection in the Chinese high-risk population.MethodsThe TNFSF4-rs1234313, TNFSF4-rs7514229, TNFSF8-rs3181366, TNFSF8-rs2295800, TNFRSF8-rs2298209, and TNFRSF8-rs2230625 SNPs were genotyped in 2309 uninfected controls, 597 subjects with spontaneous HCV clearance and 784 patients with persistent HCV infection using the TaqMan-MGB assay. The putative functions of the positive SNPs were determined using online bioinformatics tools.ResultsAfter adjusting for gender, age, high-risk population, alanine transaminase (ALT), aspartate aminotransferase (AST), IL28B-rs12979860 and rs8099917 genotypes, the non-conditional logistic regression showed that rs7514229-T, rs3181366-T, and rs2295800-C were associated with an increased risk of HCV infection (all PFDR &lt; 0.05). Combined analysis of rs7514229-T and rs3181366-T risk alleles showed that the subjects carrying 2–4 risk alleles were more susceptible to HCV infection compared with those lacking any risk allele (all P &lt; 0.001). Furthermore, the risk of HCV infection increased with the number of risk alleles (Ptrend &lt; 0.001). In silico analysis showed that rs7514229, rs3181366, and rs2295800 polymorphisms may affect the transcription of mRNA by regulating miRNA binding, TF binding, and promoter activation, respectively, which may have biological consequences.ConclusionTNFSF4-rs7514229, TNFSF8-rs3181366, and TNFSF8-rs2295800 are associated with increased risk of HCV infection in the Chinese high-risk population.
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Authors: Li Jiang , Zhang Yanfei , Jilg Alexandria L. , Wolk Donna M. , Khara Harshit S. , Kolinovsky Amy , Rolston David D. K. , Hontecillas Raquel , Bassaganya-Riera Josep , Williams Marc S. , Abedi Vida , Lee Ming Ta Michael 
Published: March 2021

BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides difficile infection cases and 15,304 controls were identified by applying the eMERGE Clostridioides difficile infection algorithm to electronic health record data. A genome-wide association study was performed using a linear mixed model, adjusted for significant covariates in the full dataset and the antibiotic subgroup. Colocalization and MetaXcan were performed to identify potential target genes in Clostridioides difficile infection - relevant tissue types.ResultsNo significant genome-wide association was found in the meta-analyses of the full Clostridioides difficile infection dataset. One genome-wide significant variant, rs114751021, was identified (OR = 2.42; 95%CI = 1.84-3.11; p=4.50 x 10-8) at the major histocompatibility complex region associated with Clostridioides difficile infection in the antibiotic group. Colocalization and MetaXcan identified MICA, C4A/C4B, and NOTCH4 as potential target genes. Down-regulation of MICA, upregulation of C4A and NOTCH4 was associated with a higher risk for Clostridioides difficile infection.ConclusionsLeveraging the EHR and genetic data, genome-wide association, and fine-mapping techniques, this study identified variants and genes associated with Clostridioides difficile infection, provided insights into host immune mechanisms, and described the potential for novel treatment strategies for Clostridioides difficile infection. Future replication and functional validation are needed.