bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated geophysical approach for Coal mine fire in Jharia coalfield, India
Authors: Pal Sanjit Kumar , Kumar Sahadev , Srivast Shalivahan 
Published: March 2021

Abstract
Jharia coalfield is one of India's largest and most productive coal fields, home of the oldest-burning coal seam fires in the world. This paper highlights the combined study comprising Surface Temperature measurement, Magnetic, and Electrical Resistivity Tomography (ERT) methods for delineation and mapping of coal fires with their depths, extension and propagation direction. Surface temperature mapping allows straight forward demarcation of coal fire areas. Magnetic data provide a map showing the earlier burned, currently burning and unburned patches based on the contrast between magnetic effects of the subsurface and fluctuations with temperatures exceeding or under the Curie temperature. The pyrolysis of coal is one of the main processes in coal fires, which results in very high conductivity. Thus, electrical resistivity tomography (ERT) is also a promising technique for the characterization of a coal fire-affected area. Most of the features of low and high resistivity associated with active fires and voids have been delimited well in the ERT sections that are generated from combine inversion of all arrays. These are also delineated well by the surface temperature mapping, and Magnetic methods. The field photographs, available coal seam and borehole lithology clearly show the suitability of the combined study for characterization of coal seam fire. A model of the coal fire, char formation and void formation resulting from coal seam fire has been established. Finally, a fire propagation model of the study area has been established based on the combined geophysical data that can be effectively used for mine hazard mitigation.
CRISPR/Cas9-induced β-carotene Hydroxylase Mutation in Dunaliella Salina CCAP19/18
Authors: Hu Lina , FENG Shu ying , Liang Gaofeng , Du Jingxia , Li Aifang , Niu Chunling 
Published: March 2021

Abstract
Dunaliella salina (D. salina) has been exploited as a novel expression system for the field of genetic engineering. However, owing to the low or inconsistent expression of target proteins, it has been greatly restricted to practical production of recombinant proteins. Since the accurate gene editing function of CRISPR/Cas system, β-carotene hydroxylase gene was chosen as an example to explore D. salina application with the purpose of improving expression level of foreign genes. In this paper, based on pKSE401 backbone, three CRISPR/Cas9 binary vectors were constructed to targeting exon 1 and 3 of the β-carotene hydroxylase of D. salina CCAP19/18 (Dschyb). D. salina mutants were obtained by salt gradient transformation method, and the expression of Dschyb gene were identified through real-time fluorescent quantitative PCR. Moreover, carotenoids content was analyzed by high-performance liquid chromatography at different time points after high intensity treatment. Compared with wild type strains, the β-carotene levels of mutants showed a significant increase, nearly up to 1.4 μg/ml, and the levels of zeaxanthin decreased to various degrees in mutants. All the results provide a compelling evidence for targeted gene editing in D. salina. This study gave a first successful gene editing of D. salina which has a very important practical significance for increasing carotene yield and meeting realistic industry demand. Furthermore, it provides an approach to overcome the current obstacles of D. salina, and then gives a strong tool to facilitates the development and application of D. salina system.
Impact of Left Atrial Geometric Remodeling on Late Atrial Fibrillation Recurrence After Catheter Ablation
Authors: Guo Fuqian , Li Caiying , Yang Lan , Chen Chen , Chen Yicheng , Ni Jiqiong , Fu Rong , Jiao Yang , Meng Yuanyuan 
Published: March 2021

Abstract
Purpose: To quantitatively investigate the impact of left atrial (LA) geometric remodeling on atrial fibrillation (AF) recurrence after catheter ablation (CA).Methods: A retrospective analysis of 105 patients with AF who underwent coronary computed tomographic angiography before CA. Risk factors for AF recurrence were identified by multivariable logistic regression analysis and used to create a nomogram.Results: After at least 12 months of follow-up, 30 patients (29%) developed recurrent AF. Patients with recurrence had a higher LA volume, LA sphericity, and a lower LA ejection fraction (LAEF) (P < 0.05). There was no significant difference in asymmetry index between the two groups (P = 0.121). Multivariable regression analysis showed that LA minimal volume index (LAVImin) (OR: 1.280, 95% CI: 1.027–1.594, P = 0.028), LA sphericity (OR: 1.268, 95% CI: 1.071–1.500, P = 0.006) and CHA2DS2-VASc score (OR: 1.326, 95% CI: 1.016–1.732, P=0.038) were independent predictors of AF recurrence. The combined model of the LA sphericity to the LAVImin substantially increased the predictive power for AF recurrence (area under the curve [AUC] = 0.736, 95% CI: 0.627–0.844, P < 0.001), with a sensitivity of 80% and a specificity of 61%. A nomogram was generated based on the contribution weights of the risk factors; the AUC was 0.769 (95% CI: 0.666–0.872) and had good internal validity.Conclusion: The CHA2DS2-VASc score, LA sphericity, and LAVImin were significant and independent predictors of AF recurrence after CA. Furthermore, the nomogram had a better predictive capacity for AF recurrence.
Docetaxel HIPEC Combined with Endostar versus Docetaxel HIPEC Alone in Treatment of Malignant Ascites：A Retrospective Study
Authors: Wu Jing , Jiang Hao , Chen Liting , Yu Bingqi , Wu Zhibing 
Published: March 2021

Abstract
Objective：The purpose of this study is to retrospectively observe the clinical efficacy and adverse reactions of docetaxel hyperthermic intraperitoneal chemotherapy (HIPEC) combined with endostar in treatment of malignant ascites. Methods：56 cases of malignant ascites admitted to Zhejiang Hospital from July 2019 and October 2020 had received no less than second-line chemotherapy. The observation group (n = 29) was treated with endostar 60mg d1,4,7 Q3W intraperitoneal injection combined with docetaxel 60mg/m2 d4 HIPEC Q3W for 2 cycles. The control group (n = 27) was just treated with docetaxel 60mg/m2 d1 HIPEC Q3W for 2 cycles. The general clinical data and qualitative data of the treatment results were processed by SPSS26.0 using χ2 test, and quantitative data were processed by t test. When P < 0.05, statistical data can be considered statistically significant.Results：There were significant differences between the observation group and the control group in objective response rate (ORR) (65.5% vs 37.0%，P=0.033)，in the improvement rate of KPS (48.3% vs 22.2%, P=0.042)，also in the median control time (57dvs 45d，P=0.027). The incidence of III to IV adverse reactions was low, and no treatment-related death was observed. There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion：Endostar combined with docetaxel HIPEC has good clinical effect on malignant ascites and can improve patients’ quality of life, and the adverse reactions can be tolerated.
Effect of The Surfactant Loaded Amount Into The Bentonite on The Elimination of Two Anionic Dyes: Adsorption, Kinetics, and Isotherm Studies
Authors: Guezzen Brahim , Adjdir Mehdi , Elaziouti Abdelkader , Didi Mohamed Amine 
Published: March 2021

Abstract
The present work focused on the preparation of hybrid-bentonite adsorbents by treating sodium bentonite (Na-B) with different amounts of hexadecyltrimethylammonium bromide (HDTMA+ Br-), corresponding to 50, 100 and 200% the value of the cation exchange capacity (CEC). The samples prepared, namely 50HDTMA-B, 100HDTMA and 200HDTMA-B, were characterized by different techniques including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA ). The removal efficiency of two anionic dyes, namely. Congo Red (CR) and Indigo Carmine (IC), from aqueous solutions, was studied as a function of the amount of HDTMA, contact time, hybrid adsorbent and initial dye concentration. In addition, a kinetic study was conducted to fit the experimental data in order to compare the adsorption rate constants and the equilibrium sorption capacities of anionic dyes on the prepared materials. The results obtained indicated that the adsorption kinetics of clay samples could be best described by the pseudo-second-order model, and the adsorption capacity of the hybrid-Bentonite is affected by the amount of modifier used. Based on Weber-Morris intra-particle diffusion equation, it was found that the CR and IC dyes diffused faster as the cationic surfactant loading increased from 0 to 100% of the CEC value. The Langmuir isotherm exhibited the best fit, with an adsorption capacity equal to 292 and 289 mg g-1, for CR and IC dyes, respectively.
Application Value of Whole-Body Pet/ct and Contrast-enhanced Brain Mri in the Diagnosis and Treatment of Patients With Synchronous Multiple Pulmonary Ground-glass Nodules
Authors: Xie Shaonan , Wang Cheng , Li Shaoteng , Deng Huiyan , Han Yaqing , Liu Guangjie , Liu Qingyi 
Published: March 2021

Abstract
Background: Synchronous multiple ground-glass nodules (SMGGNs) in synchronous multiple lung cancers (SMLCs) are associated with specific imaging findings. It is difficult to distinguish whether multiple nodules are primary tumors or metastatic lesions in the lungs. The need for positron-emission tomography/computed tomography (PET/CT) and contrast-enhanced brain magnetic resonance imaging (MRI) for these patients remains unclear. This study investigated the necessity of these two imaging examinations for SMGGN patients by means of retrospective analysis. Methods: SMGGN patients who were diagnosed and treated in the Department of Thoracic Surgery in our hospital from October 2017 to May 2020 and underwent whole-body PET/CT and/or contrast-enhanced brain MRI examinations were enrolled in this study. We analyzed the imaging and clinical characteristics of these patients to evaluate SMGGN patients’ need to undergo whole-body PET/CT and brain MRI examination. Results: A total of 87 SMGGN patients (26 men and 61 women, with a median age of 58 years at onset) were enrolled. Fifty-one patients underwent whole-body PET/CT examinations and did not show signs of primary tumors in other organs, metastatic foci in other organs, or metastasis to surrounding lymph nodes. Eighty-seven patients underwent whole-brain MRI, which did not reveal brain metastases but did detect an old cerebral infarction in 23 patients and a new cerebral infarction in one patient. Eighty-seven patients underwent surgical treatment in which 219 nodules were removed. All nodules were diagnosed as adenocarcinoma or atypical adenomatous hyperplasia. No lymph node metastasis was noted. Conclusion: For SMGGN patients, it is not necessary to perform a whole-body PET/CT examination before surgery. Contrast-enhanced brain MRI can assess the patient’s cerebrovascular function before surgery and reduce the risk of perioperative cerebrovascular accidents. Thus, it is a necessary examination.
Hyperthermia-induced Changes in EEG&nbsp;of Mice
Authors: Labra Carmen de , Pardo-Vazquez Jose L. , Cudeiro Javier , Rivadulla Casto 
Published: March 2021

Abstract
Currently, the role of hypothermia in electroencephalography (EEG) is well established. However, few studies have investigated the effect of hyperthermia on EEG, an important physiological parameter governing brain function. The aim of this work was to determine how neuronal activity in mice is affected when the temperature rise above the physiological threshold mandatory to maintain the normal body functions. In this study, a temperature-elevation protocol, from 37 ºC to 42 ºC, was applied to four female mice of 2-3 months old while EEG was recorded simultaneously. We found that hyperthermia reduces EEG amplitude by 4.36% when rising from 37 to 38 degrees and by 24.33% when it is increased to 42 degrees. Likewise, increasing the body temperature produces a very large impact on the EEG spectral parameters, reducing the frequency power at the theta, alpha, and beta bands. Our results show that hyperthermia has a global effect on the electrical activity of the brain, with an impact on physiological responses under fever but also needs to be taken into account in those situations where the temperature triggers a pathological condition (e.g., a mouse model of seizures where temperature is the trigger parameter).
Evaluation of the AirgloveTM, An Air-Regulated Thermal-Venodilatory Device Facilitating the Cannulation of Patients With Difficult Venous Access
Authors: D'Cruz Leon Gerard , Gardiner Elaine , Shukla Priyank , Dickson Dianne M. , Malaquias Tiago M. , Johnstone Scott , Yousef Zaheer , Lai Chris D , Jack Sheena , Husain Syed Arshad , Lai Francis Anthony 
Published: March 2021

Abstract
Background

Difficult venous access (DVA) can prevent delivery of life-saving intravenous (IV) fluids and medication. The Airglove™ was developed to facilitate IV access, circumventing DVA in chemotherapy patients, as current warm-water immersion (WWI) methods are sub-optimal.
Methods

This study had two parts; EAGLE-1, an observational, proof-of-concept study and EAGLE-2, a prospective, cross-sectional comparative study. EAGLE-1 recruited 80 adult participants undergoing chemotherapy for cancer with DVA where venous cannula insertion success rate was evaluated using Airglove™. EAGLE-2 was carried out on 34 adult healthy participants where the degree of venodilation by WWI and AirGlove™ in three veins; cubital-fossa cephalic vein, cubital-fossa median vein and the third dorsal carpal vein on both arms were measured using the GE Logic S8 multi-frequency linear-array transducer (L6-15MHz), two-dimension B-mode ultrasound. Baseline measurements were taken at 23oC, forearms were warmed to 38oC using the two modalities prior to ultrasound assessment.
Results

An IV cannulation success-rate of 87.5% was achieved with the Airglove™ in EAGLE-1. The EAGLE-2 study demonstrated significant venodilation enhancement in all veins examined (p < 0.001, 95% C.I) using the Airglove™. BMI, percentage body-fat, age, gender, or blood-pressure did not significantly influence the degree of venodilation.
Conclusions

Airglove™ enabled a significant percentage of successful cannulations in participants with DVA in EAGLE-1. EAGLE-2 demonstrated that Airglove™ significantly enhanced venodilation compared to WWI. There may be potential for Airglove™ to be considered in specific clinical settings where DVA is encountered.
Non-Academic Factors Influencing the Development of Empathy in Undergraduate Nursing Students: a Cross-sectional Study
Authors: Berduzco-Torres Nancy , Medina Pamela , San-Martín Montserrat , Bolton Roberto C. Delgado , Vivanco Luis 
Published: March 2021

Abstract
Background: Empathy is described as a core competence of nursing. There is abundant research evidence supporting that empathy varies according to personal characteristics and targeted training. The aim of this study was to characterize non-academic factors (personal and environmental) influencing the development of empathy in undergraduate nursing studies who are not receiving a targeted training in empathetic abilities in their nursing schools. Methods: A cross-sectional study was performed in the three nursing schools located in Cusco city, Peru (two private and one public). The Jefferson Scales of Empathy, Attitudes toward Physician-Nurse Collaboration, and Lifelong Learning, the Emotional Loneliness Scale for Adults, and the Scale of Life Satisfaction, were applied as the main measures. Also, information regarding gender, nursing school, and age, were collected. After psychometric properties were assessed, all measures were used in the development of a multivariate regression model to characterize factors of influence in empathy. Results: In a sample composed by 700 undergraduate nursing students (72 males and 628 females), a multivariate linear regression model was created. This model explained the 53% of variance of empathy and fitted all conditions necessary for inference estimations. Teamwork abilities, loneliness, age, sex, subjective well-being, and nursing school, appeared as factors influencing the development of empathy in patients’ care.Conclusions: Findings have indicated that, in absence of a targeted training, individual characteristics and characteristics associated with social and family environments play an important role of influence in the development of empathy in nursing students. These findings are also in consonance with others previously reported in different cultural settings including high-, middle- and low-income countries.
Expression of MHC Class I Polypeptide-Related Sequence A (MICA) in Colorectal Cancer
Authors: Espinoza Ingrid , Agarwal Sumit , Sakiyama Marcelo , Shenoy Veena , Orr W. Shannon , Diffalha Sameer Al , Prizment Anna , Manne Upender , Gomez Christian R. 
Published: March 2021

Abstract
Background: The major histocompatibility complex class I polypeptide-related sequence A gene (MICA) is one of the ligands of NKG2D activating receptor. MICA stimulates NKG2D that further triggers activation of natural killer cells which leads to killing of infected target cells. Tumor cells utilize escape strategies to subvert the biological function of NKG2D by shedding overexpressing MICA. In this study, we determine the levels of MICA colorectal cancers (CRCs). Additionally, we establish correlations between MICA expression and clinical characteristics. Publicly available data and bioinformatics tools are used for validation purposes.Methods: We determined the MICA RNA expression levels and correlation with clinicopathological parameters in CRC using UALCAN web-portal. We performed immunohistochemical analysis on tissue microarrays having 192 samples, acquired from 96 CRC patients to validate the expression of MICA in CRC and adjacent uninvolved tissue and investigated its prognostic significance by Kaplan-Meir and proportional hazards methods.Results: Bioinformatics and immunohistochemical analyses showed that MICA expression was significantly upregulated in CRCs as compared to uninvolved and the overexpression of MICA was independent of pathologic stage, histotype, nodal metastasis status, p53-status, as well as patient’s race, age and gender. Moreover, PROGgeneV2 survival analysis of two cohorts showed poor prognosis of CRC patients exhibiting high MICA expression.Conclusions: Overall, our findings demonstrate high expression of MICA, suggest poor prognosis of CRC patients exhibiting high MICA expression. These results can be further explored due to its potential to provide clues to the mechanistic contributing role of the tumor microenvironment to the progression of progression of CRC.
Cobalt Graphitic Carbon Nanoparticles for Catalytic Hydrogenation of 2,4-Dinitrophenol
Authors: Hammud Hassan H. , Alkhalifah Mohammed A , Traboulsi Hassan , Karnati Ranjith Kumar , Hussain Syed Ghazanfar , Trabolsi Ali , Bakir Esam 
Published: March 2021

Abstract
Cobalt carbon nanoparticles CoCNPs were prepared by pyrolysis of cobalt phenanthroline complex at different pyrolysis temperature and time of pyrolysis and used for the catalytic hydrogenation of 2,4-dinitrophenol. CoCNPs (1) and (3) were prepared by heating at 600 ºC and 800 °C respectively, while (2) was prepared by heating at 600 °C with an additional intermediate stage at 300 °C. The structures and chemical properties of the three catalysts were correlated with their catalytic activities. Among the three studied catalysts, the highest rate constant was obtained for (2) while the highest conversion was achieved by (3). Our data show that an increase in oxygen content of the cobalt carbon nano-catalyst reduces the catalytic activity, while an increase in pyrolysis temperature improves the conversion yield.
Hydrophobic Metal Organic Framework Enhanced Acoustic Wave Formaldehyde Sensor Based on Polyethyleneimine and Bacterial Cellulose Nanofilms
Authors: Wang J.L. , Shang J.H. , Guo Y.J. , Jiang Y.Y. , Xiong W.K. , Li J.S. , Yang X. , Torun H. , Fu Y.Q. , Zu X.T. 
Published: March 2021

Abstract
A surface acoustic wave (SAW) formaldehyde gas sensor was fabricated on a 42°75' ST-cut quartz substrate, with a composite sensing layer of zeolitic imidazolate framework (ZIF)-8 on polyethyleneimine (PEI)/ bacterial cellulose (BC) nanofilms. The addition of snowflake-like ZIF-8 structure on the PEI/BC sensitive film significantly improves the hydrophobicity of the SAW sensor and increases the sensor's sensitivity to formaldehyde gas. It also significantly increases the surface roughness of the sensitive film. Its hydrophobic nature prevents water molecules from entering into the internal pores of the BC film, thereby avoiding significant mass loading caused by the humidity change when the sensor is used to detect low-concentration formaldehyde gas. The Zn2+ sites at the surface of ZIF-8 improves the sensor's response to formaldehyde gas through enhancing the physical adsorptions. Experimental results show that the ZIF-8@PEI/BC SAW sensor has a response (e.g., frequency shift) of 40.3 kHz to 10 ppm formaldehyde gas at 25℃ and 30% RH. When the relative humidity was increased from 30% to 93%, the response (frequency shift) of the sensor drifts only ~5%, and there is negligible drift at a medium humidity level (~56% RH).
Development of a Winter Abnormal Cold Climate Index and Its Influencing Factors
Authors: Li CHEN , Zhang Lijuan , Jin BAN , Dong LIU , Jiaying ZHAO , Chunsheng LIU , Tao PAN 
Published: March 2021

Abstract
The prediction of extreme weather and climate events is a difficulty in the field of climate prediction. In practice, seasonal and monthly mean temperature has been used as the climate prediction index. However, the mean temperature forecast on seasonal and annual time scales cannot truly reflect the real climate situation as the mean temperature on a certain time scale smoothes abnormal cold and warm climate events. For instance, an abnormal cold climate event may occur even if the winter mean temperature is forecasted to be normal in a certain year. An abnormal warm climate event may also occur at the same time. Both affect the accuracy of climate prediction. Based on extreme weather events, this paper constructs a winter abnormal cold climate index, named WACCI, to represent the characteristics of extremely low temperature events. The index is composed of three factors, including cold duration, extremely cold temperature anomaly, and temperature cumulative anomaly. Taking Heilongjiang Province in China as the study area, relationships between WACCI and winter mean temperature, atmospheric circulation, and sea surface temperature (SST) are analyzed and compared. The analysis shows that the polar and mid-high latitude circulations have a significant impact on WACCI. The meridional circulation is dominant in the mid-high latitudes of Eurasia when the polar vortex area in the Northern Hemisphere is large, the intensity of the polar vortex is weak, and the polar vortex splits southward. Additionally, the intensity of the East Asian trough is strong and arctic oscillation (AO) is in an abnormal negative phase, which tends to result in a large WACCI. According to those atmospheric circulation factors, the regional and even global abnormal cold climate can be predicted in practice instead of using the prediction of winter mean temperature. The abnormal cold climate index proposed in this paper provides a new way for the extreme climate event occurrence trend, mechanism research, and short-term climate prediction (i.e., monthly or seasonal).