bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise comparativa entre os enxertos autógeno e beta fosfato tricálcio associado à hidroxiapatita no tratamento de levantamento de seio maxilar: revisão de literatura
Authors: Silva Bruno Santos , Ferreira Neto Milton D' Almeida 
Published: November 2021

Uma das limitações que impossibilitam o tratamento de implantes é a pneumatização de seio maxilar. Há a disposição do cirurgião dentista variados tipos de materiais de enxerto, sejam eles sintéticos ou naturais que visam possibilitar o aumento vertical ósseo e viabilizar a colocação implantes na região através da elevação de seio maxilar. O objetivo deste trabalho foi identificar, por meio de uma revisão da literatura, características histológicas, comportamento ósseo e análises tomográficas de forma comparativa entre os enxertos autógeno e Beta fosfato tricálcio associado à hidroxipatita no tratamento de levantamento de seio maxilar. Trata-se de uma revisão literária que tem como base de dados: Scielo, Lilacs e Pubmed, por meio dos descritores: “bone graft”; “biomaterials”; “Maxillary sinus”. Foram incluídos artigos publicados entre 2010 a 2021, nas línguas: portuguesa, inglesa e espanhola. Foram excluídos: monografias, cartas ao editor e editoriais. A enxertia autógena ainda é a melhor opção da atualidade, ainda que o biomaterial estudado tenha apresentado sucesso na literatura presente. Sugere-se um maior aprofundamento sobre a utilização do Beta fosfato tricálcio associado à hidroxipatita no tratamento de levantamento de seio maxilar, uma vez que, há indícios promissores de que este pode ser um forte substituo à enxertia autógena.
Análise físico-química e microbiológica de coalhadas comercializadas em feiras da cidade de Manaus-AM
Authors: Colares Janderley Almeida , Moreno Matheus Nunes , Ramos José Antonio Ferreira , Silva Luiz Henrique Guedes , Martim Salomão Rocha 
Published: December 2021

Os produtos lácteos são consumidos por serem alimentos saudáveis e com alto valor nutricional. Entre os derivados do leite, as coalhadas vêm se destacando por serem fontes de probióticos e compostos bioativos. O objetivo desse trabalho foi realizar a análise físico-química e microbiológica de coalhadas comercializadas em feiras da cidade de Manaus-AM. Dez amostras de coalhadas foram coletadas em feiras de diferentes zonas: centro-sul (ZCS), leste (ZL), norte (ZN), oeste ZO) e sul (ZS). Esses produtos foram avaliados quanto as suas características físico-químicas (pH, acidez titulável total e umidade) a qualidade sanitária (presenças de coliformes a 45 °C, Escherichia coli e Salmonella sp.). O valor médio de pH foi 3,63 e a acidez significativa (0,48%) foi verificada na amostra ZN2. A média de umidade das amostras analisadas foi de 89,14%. Nas amostras ZL1 e ZCS2 foram verificadas contaminação por coliformes a 45 °C e E. coli, mas não foi evidenciada contaminação por Salmonella sp. A presença de microrganismos indicadores de contaminação fecal apontam para a necessidade de melhorias nas boas práticas de fabricação e a implementação de sistemas de monitoramento da qualidade sanitária das coalhadas comercializadas na cidade de Manaus.
A perspectiva dos alunos do ensino médio sobre educação ambiental e sustentabilidade na escola estadual serra das cordilheiras em Colméia-TO
Authors: Silva Camila Mendonça , Farias Patrícia Bispo , Carvalho Aluísio Vasconcelos de 
Published: November 2021

O presente trabalho busca identificar se a Escola Estadual Serra das Cordilheiras de Colméia - TO trabalha a temática educação ambiental e sustentabilidade de forma interdisciplinar buscando a formação de sujeitos ambientalmente críticos e sustentáveis, partindo da avaliação da percepção dos alunos do ensino médio por meio de uma abordagem qualitativa e uso do questionário. Os dados obtidos na coleta foram analisados e tabulados baseando-se em um enfoque quanti-qualitativo, com a participação de 123 alunos. Observou-se que 94,31% ouviram falar sobre educação ambiental, no tocante aos professores trabalharem atividades relacionadas a educação ambiental em sala de aula 65,04% dos alunos responderam que apenas algumas vezes, revelando que a educação ambiental ainda não é uma temática trabalhada de forma interdisciplinar, embora a Política Nacional de Educação Ambiental (PNEA) imponha que o desenvolvimento destas atividades devem ocorrer de maneira transversal e interdisciplinar afim de tornar-se uma prática educativa integrada, contínua e permanente, em todos os níveis e modalidades do ensino formal, adequando-se as necessidades ambientais atuais, uma vez que se considera ser este um dos alicerces para buscarmos a tão sonhada sustentabilidade.
El concepto marxista de nación
Authors: Barros Carlos 
Published: December 2021

Recebido: 18/06/2019
Aprovado: 10/08/2019
El “problema nacional” resurge en el siglo XXI con gran fuerza y mayor complejidad: nacionalidades de origen medieval, Estados-nación modernos y contemporáneos, fenómenos actuales de agregación global (Europa, mundialización). Abordamos metodológicamente el tema echando mano de los clásicos del materialismo histórico, a partir del olvidado concepto de “condiciones de producción” (económicas, naturales e históricas) y sus aplicaciones a los hechos nacionales tratados por Marx y Engels en el siglo XIX.
Palabras Clave: Identidad, historia, marxismo, nación, nacional, nacionalismo.
Implementasi Pasal 17 Undang-Undang Nomor 5 tahun 1999 terhadap Rule Of Reason (Studi di Komisi Pengawasan Persaingan Usaha Wilayah II Kota Batam)
Authors: Ukas Ukas , Zulkifli Zulkifli 
Published: November 2021

Undang-Undang Nomor 5 Tahun 1999 Tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat sebenarnya tidak lepas dari krisis moneter yang kemudian berlanjut kepada krisis ekonomi yang melanda Indonesia dipertengahan tahun 1997, dimana pemerintah didasarkan bahwa sebenarnya Fundamental ekomoni Indonesia terjadi karena beberapa kebijakan pemerintah di beberapa sektor ekonomi yang kurang tepat yang menyebabkan pasar menjadi terdistorsi (penjelasan Undang-Undang Nomor 5 Tahun 1999 Tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat). Dunia persaingan usaha adalah dunia yang kompleks dan mencangkup beberapa sektor kehidupan termasuk sektor-sektor vital yang bersentuhan langsung dengan kehidupan masyarakat. Harmonisasi Pasal 17 Undang-Undang Nomor 5 Tahun 1999 Tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat yang tertuang didalam BAB IV Tentang Kegiatan yang dilarang pada bahagian Monopoli pelaku usaha dilarang melakukan penguasaan atas produksi dan/atau pemasaran barang dan/atau jasa yang dapat menyebabkan terjadinya praktek Monopoli atau persaingan usaha yang tidak sehat. Pelaku usaha patut di duga atau di anggap bersalah.
Tujuan dari pengajuan penelitian ini nantinya di harapkan untuk: Pertama, Memberikan Pemahaman Kepada Pelaku Usaha Hal-Hal atau Pendekatan Terhadap Pelanggaran Baik Bersifat Perjanjian yang di Larang Maupun Pelanggaran Bentuk Lainnya. Kedua, Memberikan Pemahaman Kepada Pihak (Pelaku Usaha) Tentang Mencegah Praktek Monopoli dan/atau Perjanjian Usaha yang Tidak Sehat Baik yang di Atur dalam Pasal 5 dan Pasal 17 Undang-Undang Nomor 5 Tahun 1999 Tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat, Termasuk Sanksi atas Pelanggaran dari Kedua Pasal Tersebut. Penelitian ini di lakukan dengan jenis Penelitian yuridis empiris yaitu penelitian yang langsung terjun ke lapangan.
Comfort Evaluation of Slow-Recovery Ejection Seat Cushions Based on Sitting Pressure Distribution
Authors: Bao Jiayi , Zhou Qianxiang , Wang Xingwei , Yin Chao 
Published: December 2021

Sitting discomfort not only affects the health of pilots carrying out long-endurance missions but also affects operational performance. The experimental objects included four ejection seat cushions: N1 was a fast-recovery foam as the comparison group, and the experimental groups were slow-recovery foams with different indentation force deflection (IFD), named N2 (hard), N3 (mid), and N4 (soft). The sitting comfort of 20 participants was tested on the four cushions by using subjective rating and sitting pressure distribution analysis. The results showed that compared with fast-recovery cushion N3 and N4 slow-recovery cushions have lower contact pressure and more uniform pressure distribution. Slow-recovery cushions that were too soft or too hard would reduce the comfort. No matter from the subjective rating or the analysis of the contact pressure data, the N3 cushion with a thickness of 3 cm and 65% IFD of 280 N had the highest comfort. In addition, the seat pressure distribution (SPD%) has a significant correlation with the subjective rating (p = 0.019, R = −0.98), which is more suitable for evaluating the comfort of the cushions. However, the slow-recovery cushions would show a decrease in support after a period of sitting, while the fast-recovery cushion could always maintain constant support.
Hypoxic Characteristic Genes Predict Response to Immunotherapy for Urothelial Carcinoma
Authors: Hong Shuo , Zhang Yueming , Cao Manming , Lin Anqi , Yang Qi , Zhang Jian , Luo Peng , Guo Linlang 
Published: December 2021

Objective: Resistance to immune checkpoint inhibitors (ICIs) has been a massive obstacle to ICI treatment in metastatic urothelial carcinoma (MUC). Recently, increasing evidence indicates the clinical importance of the association between hypoxia and immune status in tumor patients. Therefore, it is necessary to investigate the relationship between hypoxia and prognosis in metastatic urothelial carcinoma.Methods: Transcriptomic and clinical data from 348 MUC patients who underwent ICI treatment from a large phase 2 trial (IMvigor210) were investigated in this study. The cohort was randomly divided into two datasets, a training set (n = 213) and a testing set (n = 135). Data of hypoxia-related genes were downloaded from the molecular signatures database (MSigDB), and screened by univariate and multivariate Cox regression analysis to construct a prognosis-predictive model. The robustness of the model was evaluated in two melanoma cohorts. Furthermore, an external validation cohort, the bladder cancer cohort, from the Cancer Genome Atlas (TCGA) database, was t used to explore the mechanism of gene mutation, immune cell infiltration, signaling pathway enrichment, and drug sensitivity.Results: We categorized patients as the high- or low- risk group using a four-gene hypoxia risk model which we constructed. It was found that patients with high-risk scores had significantly worse overall survival (OS) compared with those with low-risk scores. The prognostic model covers 0.71 of the area under the ROC curve in the training set and 0.59 in the testing set, which is better than the survival prediction of MUC patients using the clinical characteristics. Mutation analysis results showed that deletion mutations in RB1, TP53, TSC1 and KDM6A were correlated with hypoxic status. Immune cell infiltration analysis illustrated that the infiltration T cells, B cells, Treg cells, and macrophages was correlated with hypoxia. Functional enrichment analysis revealed that a hypoxic microenvironment activated inflammatory pathways, glucose metabolism pathways, and immune-related pathways.Conclusion: In this investigation, a four-gene hypoxia risk model was developed to evaluate the degree of hypoxia and prognosis of ICI treatment, which showed a promising clinical prediction value in MUC. Furthermore, the hypoxia risk model revealed a close relationship between hypoxia and the tumor immune microenvironment.
Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
Authors: Duan Fangfang , Li Jianpei , Huang Jiajia , Hua Xin , Song Chenge , Wang Li , Bi Xiwen , Xia Wen , Yuan Zhongyu 
Published: December 2021

Background: Altered copper levels have been observed in several cancers, but studies on the relationship between serum copper and early-stage triple-negative breast cancer (TNBC) remain scare. We sought to establish a predictive model incorporating serum copper levels for individualized survival predictions.Methods: We retrospectively analyzed clinicopathological information and baseline peripheric blood samples of patients diagnosed with early-stage TNBC between September 2005 and October 2016 at Sun Yat-sen University Cancer Center. The optimal cut-off point of serum copper level was determined using maximally selected log-rank statistics. Kaplan-Meier curves were used to estimate survival probabilities. Independent prognostic indicators associated with survival were identified using multivariate Cox regression analysis, and subsequently, prognostic nomograms were established to predict individualized disease-free survival (DFS) and overall survival (OS). The nomograms were validated in a separate cohort of 86 patients from the original randomized clinical trial SYSUCC-001 (SYSUCC-001 cohort).Results: 350 patients were eligible in this study, including 264 in the training cohort and 86 in the SYSUCC-001 cohort. An optimal cut-off value of 21.3 μmol/L of serum copper was determined to maximally divide patients into low- and high-copper groups. After a median follow-up of 87.1 months, patients with high copper levels had significantly worse DFS (p = 0.002) and OS (p &lt; 0.001) than those with low copper levels in the training cohort. Multivariate Cox regression analysis revealed that serum copper level was an independent factor for DFS and OS. Further, prognostic models based on serum copper were established for individualized predictions. These models showed excellent discrimination [C-index for DFS: 0.689, 95% confidence interval (CI): 0.621–0.757; C-index for OS: 0.728, 95% CI: 0.654–0.802] and predictive calibration, and were validated in the SYSUCC-001 cohort.Conclusion: Serum copper level is a potential predictive biomarker for patients with early-stage TNBC. Predictive nomograms based on serum copper might be served as a practical tool for individualized prognostication.
Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
Authors: Ye Li-fang , Li Xue-ling , Wang Shao-mei , Wang Yun-fan , Zheng Ya-ru , Wang Li-hong 
Published: December 2021

Background: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dilated cardiomyopathy and reduced EF in our center and who underwent follow-up examination of EF via echocardiography after 6 months. The EF improved at 6 months in 88 participants, who were included in the heart failure with recovered EF (HFrecEF) subgroup. Patients in whom the EF remained reduced were included in the heart failure with persistently reduced EF (persistent HFrEF) subgroup. Our analyses revealed that EF increase correlated with age (r = −0.254, P = 0.001), left ventricular diastolic dimension (LVDD; r = −0.210, P = 0.004), diabetes (P = 0.034), brain natriuretic peptide (r = −0.199, P = 0.007), and BMI grade (P = 0.000). BMI grade was significantly associated with elevated EF after adjustment for other variables (P = 0.001). On multivariable analysis, compared to patients with persistent HFrEF, those with HFrecEF had higher BMI [odds ratio (OR) = 2.342 per one standard deviation increase; P = 0.001] and lower LVDD (OR = 0.466 per one standard deviation increase; P = 0.001). ROC-curve analysis data showed that BMI &gt; 22.66 kg/m2 (sensitivity 84.1%, specificity 59.4%, AUC 0.745, P = 0.000) indicate high probability of EF recovery in 6 months.Conclusions: Our data suggest that higher BMI is strongly correlated with the recovered EF and that BMI is an effective predictor of EF improvement in patients with heart failure and reduced EF.
New Oral Anticoagulants vs. Vitamin K Antagonists Among Patients With Cardiac Amyloidosis: Prognostic Impact
Authors: Cariou Eve , Sanchis Kevin , Rguez Khailène , Blanchard Virginie , Cazalbou Stephanie , Fournier Pauline , Huart Antoine , Roussel Murielle , Cintas Pascal , Galinier Michel , Carrié Didier , Maury Philippe , Lavie-Badie Yoan , Lairez Olivier 
Published: December 2021

Background: Atrial arrhythmia (AA) is common among patients with cardiac amyloidosis (CA), who have an increased risk of intracardiac thrombus. The aim of this study was to explore the prognostic impact of vitamin K-antagonists (VKA) and direct oral anticoagulants (DOAC) in patients with CA.Methods and Results: 273 patients with CA and history of AA with long term anticoagulation−69 (25%) light chain amyloidosis (AL), 179 (66%) wild-type transthyretin amyloidosis (ATTRwt) and 25 (9%) variant transthyretin amyloidosis (ATTRv)–were retrospectively included between January 2012 and July 2020. 147 (54%) and 126 (46%) patients received VKA and DOAC, respectively. Patient receiving VKA were more likely to have AL with renal dysfunction, higher NT-proBNP and troponin levels. Patients with ATTRwt were more likely to receive DOAC therapy. There were more bleeding complications among patients with VKA (20 versus 10%; P = 0.013) but no difference for stroke events (4 vs. 2%; P = 0.223), as compared to patients with DOAC. A total of 124 (45%) patients met the primary endpoint of all-cause mortality: 96 (65%) and 28 (22%) among patients with VKAs and DOACs, respectively (P &lt; 0.001). After multivariate analysis including age and renal function, VKA was no longer associated with all-cause mortality.Conclusion: Among patients with CA and history of AA receiving oral anticoagulant, DOACs appear to be at least as effective and safe as VKAs.
Influence of Intrinsic Aerobic Exercise Capacity and Sex on Cardiac Injury Following Acute Myocardial Ischemia and Reperfusion
Authors: Alsahly Musaad B. , Zakari Madaniah O. , Koch Lauren G. , Britton Steven , Katwa Laxmansa C. , Lust Robert M. 
Published: December 2021

Purpose: Previous reports have suggested that active exercise aside, intrinsic aerobic running capacity (Low = LCR, high = HCR) in otherwise sedentary animals may influence several cardiovascular health-related indicators. Relative to the HCR phenotype, the LCR phenotype is characterized by decreased endothelial reactivity, increased susceptibility to reperfusion-induced arrhythmias following short, non-infarction ischemia, and increased diet-induced insulin resistance. More broadly, the LCR phenotype has come to be characterized as a “disease prone” model, with the HCRs as “disease resistant.” Whether these effects extend to injury outcomes in an overt infarction or whether the effects are gender specific is not known. This study was designed to determine whether HCR/LCR phenotypic differences would be evident in injury responses to acute myocardial ischemia-reperfusion injury (AIR), measured as infarct size and to determine whether sex differences in infarction size were preserved with phenotypic selection.Methods: Regional myocardial AIR was induced in vivo by either 15 or 30 min ligation of the left anterior descending coronary artery, followed by 2 h of reperfusion. Global ischemia was induced in isolated hearts ex vivo using a Langendorff perfusion system and cessation of perfusion for either 15 or 30 min followed by 2 h of reperfusion. Infarct size was determined using 2, 3, 5–triphenyltetrazolium chloride (TTC) staining, and normalized to area at risk in the regional model, or whole heart in the global model. Portions of the tissue were paraffin embedded for H&amp;E staining and histology analysis.Results: Phenotype dependent differences in infarct size were seen with 15 min occlusion/2 h reperfusion (LCR &gt; HCR, p &lt; 0.05) in both regional and global models. In both models, longer occlusion times (30 min/2 h) produced significantly larger infarctions in both phenotypes, but phenotypic differences were no longer present (LCR vs. HCR, p = n.s.). Sex differences in infarct size were present in each phenotype (LCR male &gt; LCR female, p &lt; 0.05; HCR male &gt; HCR female, p &lt; 0.05 regardless of length of occlusion, or ischemia model.Conclusions: There is cardioprotection afforded by high intrinsic aerobic capacity, but it is not infinite/continuous, and may be overcome with sufficient injury burden. Phenotypic selection based on endurance running capacity preserved sex differences in response to both short and longer term coronary occlusive challenges. Outcomes could not be associated with differences in system characteristics such as circulating inflammatory mediators or autonomic nervous system influences, as similar phenotypic injury patterns were seen in vivo, and in isolated crystalloid perfused heart ex vivo.
Clinical Application of Individualized Pulmonary Bi-Orifice for the Reconstruction of Right Ventricular Outflow Tract in Tetralogy of Fallot
Authors: Wu Ming , Fan Chengming , Liu Jian , Iroegbu Chukwuemeka Daniel , Chen Wangping , Huang Peng , Tang Mi , Wu Xun , Wang Chunle , Xiang Kun , Zhou Wenwu , Yang Jinfu 
Published: December 2021

Objective: The study aims to establish a new method in the Tetralogy of Fallot (ToF) called the pulmonary valve bi-orifice method (pulmonary annular sparing with an individualized autologous pericardial patch; thus, two orifices are formed at the level of the pulmonary valve annulus) to reconstruct the right ventricular outflow tract (RVOT).Methods: A retrospective analysis of 128 TOF patients from October 2009 to June 2018 with severe pulmonary valve dysplasia who underwent transvalvular annular patch (TAP) procedure (control group) or an individualized pulmonary valve bi-orifice procedure (observation group) were studied. The RVOT for each patient in the observation group was individually reconstructed per the patient's weight and the size of the autologous pulmonary valve using the bi-orifice method; however, increasing the cross-sectional area of the pulmonary valve annulus without destroying its integrity. The result was then compared to the control group, where TAP procedures were applied to evaluate the short to mid-term outcome(s). An in vitro simulation test was used to verify the anti-regurgitation mechanism of the new method.Results: The in vitro simulation test indicated that the anti-regurgitation mechanism was completed by the pericardial patch and the autologous pulmonary valve movement toward each other. Thus, for clinical applications, patients in both groups were compared. The results showed no significant differences in cardiopulmonary bypass and aortic cross-clamp time, mechanical ventilation, and ICU and post-operative residence between the two groups.During the follow-up period (3- to 12-years), 14 patients in the observation group had mild regurgitation after surgery (22.2%), while 10 patients had moderate pulmonary regurgitation (15.8%) with no right ventricular (RV) dilation. On the other hand, 22 patients (39.6%) had moderate to severe regurgitation in the control group, while left pulmonary artery stenosis occurred in one patient. In the control group, six patients (9.2%) with severe RV dilation were reoperated.Conclusion: Individualized pulmonary valve bi-orifice procedure is a safe and excellent method for reconstructing RVOT in ToF.