bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain Response To A Knee Proprioception Task Among Persons With Anterior Cruciate Ligament Reconstruction And Controls
Authors: Strong Andrew , Grip Helena , Boraxbekk Carl-Johan , Selling Jonas , Häger Charlotte K. 
Published: October 2021

Abstract
Knee proprioception deficits and neuroplasticity have been indicated following injury to the anterior cruciate ligament (ACL). Evidence is however scarce regarding brain response to knee proprioception tasks and the impact of ACL injury. Twenty-one persons with unilateral ACL reconstruction (mean 23 months post-surgery) of either the right (n = 10) or left (n = 11) knee, as well as 19 controls (CTRL) matched for sex, age, height, weight and current activity level, performed a knee joint position sense (JPS) test during simultaneous functional magnetic resonance imaging (fMRI). Integrated motion capture recorded knee kinematics. Recruited brain regions included somatosensory cortices, prefrontal cortex and insula. Neither brain response nor JPS errors differed between groups, but across groups significant correlations revealed that greater errors were associated with greater ipsilateral response in the anterior cingulate (r = 0.476, P = 0.009), supramarginal gyrus (r = 0.395, P = 0.034) and insula (r = 0.474, P = 0.008). This is the first study to capture brain response using fMRI in relation to quantifiable knee JPS. Activated brain regions have previously been associated with sensorimotor processes, body schema and interoception. Our innovative paradigm can help to guide future research investigating brain response to lower limb proprioception.
Association of Serum Uric Acid with Lung Function in the National Health and Nutrition Examination Survey (NHANES), 2007-2012: A Cross-Sectional Study.
Authors: Luo Wen , Wang Wanyu , Yao Xiangyang , Shi Yonghong , Lu Fang , Wu Dinghui , Lin Yihua 
Published: October 2021

Abstract
Background

Evidence regarding the relationship between serum uric acid and lung function was controversial. Therefore, this study is designed to investigate whether serum uric acid was independently related to lung function in the National Health and Nutrition Examination Survey (NHANES) (2007-2012) after adjusting for other covariates.
Methods

The present study was a cross-sectional study. The total participants from NHANES (2007-2012) were 30442. After exclusion of subjects, 9474 subjects remained for the final analysis. The target independent variable and the dependent variable were serum uric acid measured at baseline and lung function respectively. Covariates involved in this study included age, sex, race, income-poverty ratio, body mass index, systolic blood pressure, diastolic blood pressure, blood urea nitrogen, cholesterol, creatinine, total protein, FeNO, calcium, alcohol drinking, smoke, phosphorus and total bilirubin.
Results

The average age of 9626 selected participants was 37.12 ± 16.03 years old, and about 49.19% of them were male. Result of fully adjusted linear regression showed serum uric acid was negatively associated with FEV1, FEV and PEF after adjusting confounders (Odds ratio (OR)= for FEV1 [-21.28 (-32.26, -10.30)], for FVC [-26.79 (-40.56, -13.01)] and for PEF [-72.19 (-101.93, -42.46)]). FEV1 and PEF were found a non-linear relationship with serum uric acid and the inflection points was 6.5mg/dl and 7.3 mg/dl respectively. The effect sizes and the confidence intervals in FEV1 and PEF of the left and right sides of inflection point were -11.50 (-25.55, 2.54) and -48.07 (-74.49, -21.66), -38.17 (-71.91, -4.43) and -311.11 (-427.28, -194.94) respectively.
Conclusions

We find serum uric acid was negatively associated with FEV1, FVC and PEF in a general population. Besides, there is a threshold effect on the independent association between serum uric acid and FEV1 and PEF. Those results are only found in the general population. Further epidemiologic studies will still be required to confirm this reverse association between serum uric acid and lung function.
Vibration and Noise Analysis of Acetoxime Modified Tio2 Coating Over Steel Alloy
Authors: Saini Ajay , Singh Dalip , Sonewane Shubham , Yadav Ashu 
Published: October 2021

Abstract
In this research work, conventional gun spray method is used to coat oximemodifiedtitanium(IV) isopropoxide on steel to find out damping behaviour of coating. The most conventional method is modal analysis is used to measure vibration and noise damping of bare and titania coated samples. Test results revealed that a thin coating has improved the vibration and noise damping when compare with bare sample. SEM, EDX and AFM analysis were carried out to study morphology, coating thickness and composition of coating on the sample surface.
Gesture Recognition Via Learning Deep Spatio-Temporal Features In Wi-Fi Sensing
Authors: Xie Jianxiao , Ye Wei , Xu Kai 
Published: October 2021

Abstract
Internet of Things (IoT) expects to incorporate massive machine-type (MCT) devices, such as vehicles, sensors, and wearable devices, which brings a large number of application tasks that need to be processed. Additionally, data collected from various devices needs to be executed and processed in a timely, reliable, and efficient manner. Gesture recognition has enabled IoT applications such as human-computer interaction and virtual reality. In this work, we propose a cross-domain device-free gesture recognition (DFGR) model, that exploits 3D-CNN to obtain spatiotemporal features in Wi-Fi sensing. To adapt the sensing data to the 3D model, we carry out 3D data segment and supplement in addition to signal denoising and time-frequency transformation. We demonstrate that our proposed model outperforms the state-of-the-art method in the application of DFGR even cross 3 domain factors simultaneously, and is easy to converge and convenient for training with a less complicated hierarchical structure.
Process Knowledge Graph Modeling Techniques and Application Methods for Ship Heterogeneous Models
Authors: Liu Jinfeng , Dong Jianwei , Jing Xuwen , Cao Xuwu , Du Chenxiao , Li Lei 
Published: October 2021

Abstract
In the process design and reuse of marine component products, there are a lot of heterogeneous models, causing the problem that the process knowledge and process design experience contained in them are difficult to express and reuse. Therefore, a process knowledge representation model for ship heterogeneous model is proposed in this paper. Firstly, the multi-element process knowledge graph is constructed, and the heterogeneous ship model is described in a unified way. Then, the multi-strategy ontology mapping method is applied, and the semantic expression between the process knowledge graph and the entity model is realized. Finally, by obtaining implicit semantics based on case-based reasoning and checking the similarity of the matching results, the case knowledge reuse is achieved, to achieve rapid design of the process. This method provides reliable technical support for the design of ship component assembly and welding process, greatly shortens the design cycle, and improves the working efficiency. In addition, a case study of the test model is carried out to verify the feasibility and efficiency of the proposed method.
Controlling of Lattice Strains for Crack-Free and Strong Ferroelectric Barium Titanate Films by Post-Thermal Treatment
Authors: Kim Bogyu , Jeon Young-Uk , Lee Chulwoo , Kim Hyebi , Kim Young-Hwan , Kim In Soo , Lee Byeong-Hyeon , Han Jae-Hoon , Ahn Dae-Hwan , Kim Soo Jin , Kim Young Duck , Han Il Ki , Lee Kwanil , Kim Jongbum , Kang JoonHyun 
Published: October 2021

Abstract
In this study, we experimentally demonstrate the fabrication of ultra-smooth and crystalline barium titanate (BTO) films on magnesium oxide (MgO) substrates by engineering the lattice strain and the crystal structure via thermal treatment. We first grow crack-free BTO thin films at oxygen-depleted condition, and enhance the ferroelectric characteristics by post-annealing at high temperature. The roughened surface due to recrystallization during post-annealing is controlled by chemical-mechanical polishing (CMP) to retain the ultra-smooth surface morphology. Oxygen-depleted deposition allows a highly strained BTO film to grow on a MgO substrate with an ultra-smooth surface, and post-annealing relaxes the strain, resulting in the enhancement of the ferroelectricity. From Raman spectroscopy, reciprocal space map (RSM), and capacitance–voltage (C–V) curve measurements, we observe that the ferroelectricity of the BTO film strongly depends on the lattice strain relaxation and the phase transition from a-axis to c-axis oriented crystal structure.
Substance Use Workforce Training Needs during Intersecting Epidemics: An Analysis of Events Offered by a Regional Training Center from 2017-2020
Authors: Scott Kelli , Salas Mika D.H. , Bayles Denise , Sanchez Raymond , Martin Rosemarie A , Becker Sara J 
Published: October 2021

Abstract
Background: Intersecting opioid overdose, COVID-19, and systemic racism epidemics havebrought unprecedented challenges to the addiction treatment and recovery workforce. From 2017-2020, the New England Addiction Technology Transfer Center (ATTC) collected data in real-time on the training and technical assistance (TA) requested and attended by the front-line workforce. This article synthesizes practice-based evidence on the types of TA requests, topics of TA, attendance numbers, and socio-demographics of TA attendees over a 3-year period spanning an unprecedented public health syndemic. Methods: We assessed TA events hosted by the New England ATTC using SAMHSA’s Performance Accountability and Reporting System post-event survey data from 2017-2020. Events were coded by common themes to identify the most frequently requested training types/topics and most frequently attended training events. We also evaluated change in training topics and attendee demographics over the three-year timeline.Results: A total of 258 ATTC events reaching 10,143 participants were analyzed. The number of TA events and attendance numbers surged in the 2019-2020 fiscal year as TA events shifted to fully virtual during the COVID-19 pandemic. The absolute number of opioid-related events increased, but the relative proportion remained stable over time. The relative proportions of events and attendance rates focused on evidence-based practice and health equity both increased over the 3-year period, with the largest increase after the onset of the pandemic and the murder of George Floyd. As events shifted to virtual, events were attended by providers with a broader range of educational backgrounds. Conclusions: Results of the current analysis indicate that the demand for TA increased during the pandemic, with a prioritization of TA focused on evidence-based practice and health equity. The practice-based evidence generated from the New England ATTC may help other training and TA centers to anticipate and nimbly respond to the needs of the workforce in the face of the intersecting epidemics.
Virtue and Care Ethics &amp; Humanism in Medical Education: A Scoping Review
Authors: Doukas David J. , Ozar David T. , Darragh Martina , de Groot Janet M. , Carter Brian S. , Stout Nathan 
Published: October 2021

Abstract
PURPOSE:This scoping review explores how virtue and care ethics are incorporated into health professions education and how these factors may relate to the development of humanistic patient care.METHOD:Our team identified citations in the literature emphasizing virtue ethics and care ethics (in PubMed, NLM Catalog, WorldCat, EthicsShare, EthxWeb, Globethics.net, Philosopher’s Index, and ProQuest Central) lending themselves to constructs of humanism curricula. Our exclusion criteria consisted of non-English articles, those not addressing virtue and care ethics and humanism in medical pedagogy, and those not addressing aspects of character in health ethics. We examined in a stepwise fashion whether citations: 1) Contained definitions of virtue and care ethics; 2) Implemented virtue and care ethics in health care curricula; and 3) Evidenced patient-directed caregiver humanism.RESULTS: 811 citations were identified, 88 intensively reviewed, and the final 25 analyzed in-depth. We identified multiple key themes with relevant metaphors associated with virtue/care ethics, curricula, and humanism education.CONCLUSIONS:This research sought to better understand how virtue and care ethics can potentially promote humanism and identified themes that facilitate and impede this mission.
Knowledge and Perceptions of Medical Students After Using Kahoot! Towards General Pharmacology Practical Sessions at King Abdulaziz University
Authors: Kamel Fatemah Omar Abdullah , AlShawwa Lana Adey Fareed 
Published: October 2021

Abstract
Background College students often do not study effectively or devote enough time to study and may experience a lot of stress which negatively affects their learning. Game-based Electronic learning (GbEl) has been shown to greatly motivate students, encourage learning and improve academic performance. Kahoot! is one such electronic tool, but its effectiveness in the medical education sector in the Kingdom of Saudi Arabia has never been evaluated. MethodsThis study aimed to determine the effect of the interactive software, Kahoot!, on the participation and academic performance of 274 medical students in their general pharmacology practical sessions at the faculty of medicine at King Abdulaziz University (KAU). The pharmacology sessions were divided into two groups: control and Kahoot! and after each session, students took ‘pre’ and ‘post-tests’ to assess the effect on learning. On the final day of the course, students were given a questionnaire to determine their attitudes and perceptions toward the learning process using Kahoot!. ResultsThe results showed that Kahoot! was an effective, enjoyable, and interactive formative tool that increased student engagement, motivation, and improved academic achievement. Teachers involved in the study agreed on the advantages of using Kahoot! largely out-weighed disadvantages.
Machine Learning Tools For off-Target Early Safety Assessment of Small Molecules In Drug Discovery (Single Task Neural Networks Vs Automated Machine Learning)
Authors: Naga Doha , Muster Wolfgang , Musvasva Eunice , Ecker Gerhard F. 
Published: October 2021

Abstract
Unpredicted drug safety issues constitute the majority of failures in the pharmaceutical industry according to several studies[1-3]. Some of these preclinical safety issues could be attributed to the non-selective binding of compounds to targets other than their intended therapeutic target, causing undesired adverse events. Consequently, pharmaceutical companies including Roche, routinely run in-vitro safety screens to detect off-target activities prior to preclinical and clinical studies.Hereby we present a machine learning framework aiming at the prediction of our in-house 50 off-target panel[4] activities for ~ 4000 compounds, directly from their structure. This framework is intended to guide chemists in the drug design process prior to synthesis and accelerate drug discovery. It incorporates different ML approaches such as deep learning and automated machine learning. Outcomes from different methods are compared in terms of efficiency and efficacy. The most important challenges and factors impacting model construction and performance in addition to suggestions on how to overcome such challenges are also discussed.
Novel Multifunctional Magnetic Nanoparticles：An Efficient Theranostic Platform for Magnetic Resonance Imaging and Targeted Therapy of Cervical Cancer
Authors: Yao Shu , Li Li , Liu Chang , Wang Ziying , Liu Hong , Su Xuantao , Lu Zaijun , Liu Zhiping , Qiao Xu , Song Li , Chu Ran , Meng Jinyu , Pan Xiyu , song Kun , Kong Beihua 
Published: October 2021

Abstract
Background: The high incidence and mortality rates of cervical cancer pose a serious threat to women's health. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and poor therapeutic efficiency. In order to overcome these shortcomings, a novel multifunctional magnetic nanoparticles drug delivery system with tumor targeting and magnetic resonance imaging was developed to achieve precise diagnosis and targeted tumor killing effects.Methods: Transmission electron microscopy, dynamic light scatting and ultraviolet methods were used to characterize the nanoparticles in vitro. Cell function tests were performed by scratch, transwell and flow cytometry assays. MTT was used to detect the toxicity of the nanoparticles. The motion trajectory, drug release and uptake studies were carried out in vitro. The in vivo pharmacokinetic and drug distribution studies were verified by high performance liquid chromatography methods. Attenuation of the MRI signal by the nanoparticles and their enhanced antitumor efficiency were examined in vivo in mouse cervical cancer models. Sequencing and proteomics were used to detect the key antitumor molecules of the nanoparticles.Results: Multifunctional magnetic nanoparticles coated with ferric oxide nanoparticles and doxorubicin hydrochloride (DOX-Fe3O4-PEG-PLA-NPs) was prepared successfully. No toxicity was detected of PEG-PLA-NP, however, the tumor killing effect was enhanced under the alternating magnetic field significantly. The drug-release study showed that the cumulative release rates of NP groups were much less than free DOX group, while the drug release rate increased under acidic condition. In addition, DOX-Fe3O4-PEG-PLA-NPs showed improved internalized into carcinoma cells under magnetic field significantly. In vivo studies demonstrated that the combined therapy under an alternating magnetic field displayed improved therapeutic effect when compared with individual therapies as documented by the delayed tumor growth, inhibition of metastasis, and prolonged survival. The in vitro and in vivo MRI results showed that the multifunctional magnetic nanomaterial had a better MRI signal reduction effect and a higher T2 relaxation rate.Conclusions: We developed an cervical cancer targeting nano-carrier drug delivery system successfully, which showed perfect excellent T2 contrast magnetic resonance imaging, chemotherapy-sensitizing, tumor targeting , and anti-tumor effect, thus have the potential to be a new theranostic strategy for ovarian cancer patients.
Drug Related Problems and Complications of Bacterial Meningitis Admitted to Pediatrics Ward in Developing Country
Authors: Kebede bezie , abebe abinet 
Published: October 2021

Abstract
Background: Bacterial meningitis is considered a medical emergency and it is a life-threatening infection that requires immediate treatment. However, even with an early diagnostic approach and adequate treatment with effective antibiotics, death and different complications may occur.Objective: This study aimed to assess drug related problems and its association on bacterial meningitis related complication.Method: A prospective hospital-based observational study was conducted at the pediatric ward of Hiwot Fana Specialized teaching hospital, Harar. This study was conducted longitudinally for consecutive one year from December 30/2019-Juanuary 1/2021 admitted to pediatrics ward. All pediatrics admitted with the diagnosis of bacterial meningitis and fulfilled the inclusion criteria. To identify independent predictors of bacterial meningitis related complication, binary logistic regression model were used using STATA, version 14.2. Stastical significance was declared at p<0.05Result: After 1 year follow up, 384 children were included in this study with a response rate of 98.1%. Males(55.73%) outnumbered. The mean age and cerebrospinal fluid protein were 5.01±0.19 and 60.5±4.53 respectively. Nearly half of the child had co-morbidity in addition to admission diagnosis, meningitis. Two hundred twenty four(58.33%) patients exposed to at least one type of drug related problem. One hundred twenty one (31.51%) children were developed bacterial meningitis related complications. Drug related problem(AOR=6.26, 95%CI: 3.58-10.93), cerebrospinal fluid protein(AOR=9.38, 95%CI: 9.81.9-96), age(AOR=0.01, 95%CI: 0.13-0.19), duration of illness(AOR=) and co-morbidity(AOR=13.18, 95%CI: 1.81-5.6) were absolutely associated with the occurrence of complication. Conclusion: Drug related problem and associated complications were substantial among children admitted with meningitis. This study identified significant association between drug related problem and complication. Health professional shall prevent drug related problem to prevent associated complication.
Foot Function Determination: Agreement Between Tests?
Authors: Dodelin Damien , Tourny Claire , L’Hermette Maxime 
Published: October 2021

Abstract
Background:

Foot pronation is generally linked to musculoskeletal injuries, especially in relation to joint deviation caused by pronation during dynamic activities. However, no consensus appeared in the methodological way to determine foot function, and several tests propose to identify foot pronation under different conditions, from static testing to running. The aim of this study was to determine the level of agreement between different foot function classification measures.
Methods:

One hundred and six subjects completed 5-foot function tests at standing position, walking and running. Foot Posture Index (FPI) was undertaken to determine foot function during static posture. The Center of Pressure Excursion Index (CPEI) and 3 Foot Balance tests (FBs) were realized during walking and running trials to assess pronation during dynamic activities. Agreement between the measures was determined using the Cohen’s Kappa coefficient (K) between 2 measures and the Fleiss Kappa (FK) between 3 or more measures.
Results:

Overall agreement between the measures reported a fair agreement (Kf = 0.2). Static and walking foot tests determination agreement was moderate (K = 0.5), while agreement between FPI and FBs tests were fair (K < 0.4). Fair results were also reported between walking and running tests (K < 0.4). The concordance between running tests classification was fair (Kf = 0.2).
Conclusions:

The lack of agreement between tests confirms the need for a consensus on an appropriate measurement of the foot function. Static foot tests are mainly used to determine foot function during dynamic activities. However, the lack of agreement between tests could question the relevance of the static foot function assessments. The FPI reported a moderate agreement with the walking classification test, but it should be accompanied by a dynamic test in order to limit the risk of misinterpretation.