bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Withdrawal and Neurocognitive Correlates in Schizophrenia
Authors: De Donatis Domenico , Porcelli Stefano , De Ronchi Diana , Pich Emilio Merlo , Kas Martien J , Bilderbeck Amy , Serretti Alessandro 
Published: May 2021

Abstract
Background: Social withdrawal constitutes a clinical manifestation of social dysfunction in SCZ that has a high impact on the quality of life of patients. Poor neurocognitive performance has been associated with poor functional outcome in SCZ in past studies. Nonetheless, the likely association between neurocognition and social withdrawal has never been investigated. The aim of our study was to investigate in a large and heterogeneous sample of SCZ patients cross-sectional associations between neurocognitive domains and social withdrawal. Methods: The sample included 761 SCZ patients who completed the baseline visit in the CATIE study. Neurocognition was assessed by a comprehensive battery of tests resulting in 5 domain scores and a composite score. Social withdrawal was measured by a specific item of the Heinrichs-Carpenter Quality of Life Scale. Bivariate correlations, ANOVA and multiple regression analysis were conducted using STATISTICA software package (StatSoft, Inc. Tulsa, OK, USA). Statistical significance was tested at p value < 0.05. Results: Social withdrawal was associated with a lower score in the neurocognitive composite score and in “Verbal memory”, “Processing speed” and “Working memory” scores. “Verbal memory” score showed the strongest association with social withdrawal. 8% of the total variance of social withdrawal was explained by these three cognitive domains and additional clinical and socio-demographic factors (education years, PANSS positive symptoms score, employment). Conclusions: Our study showed that in a large and real-world representative sample of SCZ patients, social withdrawal was associated with neurocognitive deficits involving verbal memory, processing speed and working memory domains. Our results confirmed the wide heterogeneity and specificity of the correlation between neurocognitive domains and indicators of functional outcome in SCZ, underlining the role of certain neurocognitive abilities in social withdrawal.
Knowledge of End-of-life Wishes by Physicians and Caregivers in Cancer Patients
Authors: Calvache Jose A , Moreno Socorro , Prue Gillian , Reid Joanne , Ahmedzai Sam , Arango-Gutierrez Angelica , Ardila Liliana , Arroyo Lucia I , de Vries Esther 
Published: May 2021

Abstract
Objectives: To describe communication regarding cancer patient’s end-of-life (EoL) wishes by physicians and caregivers.Methods: An online questionnaire and telephone-based surveys were performed with physicians and caregivers respectively in three teaching hospitals in Colombia who had been involved in the EoL care of cancer patients. Results: For 138 deceased patients we obtained responses from physicians and caregivers. In 32% physicians reported they spoke to the caregiver and in 17% with the patient regarding EoL decisions. In most cases with absence of a conversation, physicians indicated the treatment option was “clearly the best for the patient” or that it was “not necessary to discuss treatment with the patient”.Twenty-six percent of the caregivers indicated that someone from the medical team spoke with the patient about treatment, and in 67% who had a conversation, caregivers felt that the provided information was unclear or incomplete. Physicians and caregivers were unaware if the patient had any advance care directive (ACD) in 65% and 51% of cases, respectively, with a very low absolute agreement (34%).Conclusion: There is a lack of open conversations regarding EoL in patients with advanced cancer with their physicians and caregivers in Colombia. Communication strategies are urgently needed.
Dormancy Induces the Formation of Persisters in the Candida Albicans-staphylococcus Epidermidis Mixed Species Biofilm
Authors: Yang jichen , Xiang Bingquan , Wang Wei , Rao Sunyin , Cao Run , Xiao Shouyong , Cui Xin , Huang Yunchao , ye lianhua 
Published: May 2021

Abstract
Background: Persisters make biofilm infections difficult to cure, the low content of persisters in biofilm and the difficulty of obtaining them are outstanding problems in research, finding a reliable method to obtain a sufficient amount of persisters is the key to research. Methods: In this study, C.albicans strain ATCC10231 and S.epidermidis ATCC35984 were used to culture mixed biofilms on the surface of a titanium metal coupon. Tetracycline, gentamicin, 5-fluorocytosine(5-Fc), caspofungin, rifampicin, fluconazole and carbonyl cyanide m-chlorophenylhydrazone (CCCP) were used to induce the dormancy of biofilms to produce persisters. Ciprofloxacin and amphotericin B were used to kill the non dormant bacteria, and then the persisters were screened. Results:The study showed that dormancy induced by tetracycline and 5-Fc could significantly increase the persister levels of S.epidermidis and C.albicans, respectively. After the induced persisters were re-cultured, there was no significant change in antibiotic sensitivity compared with before induction.Scanning electron microscope(SEM) observations showed that after dormancy induction, the surface morphology of C.albicans in the mixed biofilm showed convex changes, and the volume of S.epidermidis decreased. Confocal laser scanning microscope (CLSM)observation showed that the mixed biofilm with high content of persisters did not dissolve under the killing of antibiotics, and the biofilm with low content of persisters dissolved in large area. Conclusions: Induction of dormancy is a reliable method for the formation of persistent bacteria in C.albicans-S.epidermidis mixed biofilm.
Exercise Improves Bone Formation by Upregulating the Wnt3a/β-catenin Signalling Pathway in Type 2 Diabetic Mice
Authors: Chen Xianghe , Yang Kang , Sun Peng , Zhao Renqing , Liu Bo , Lu Pengcheng 
Published: May 2021

Abstract
Bone formation in type 2 diabetes mellitus (T2DM) is inhibited by decreased bone formation capacity. Exercise can significantly improve bone metabolism; however, the effect and mechanism of exercise on bone formation in T2DM is not known. In this study, we used the method of a high-fat diet and injecting STZ to build a T2DM mouse model, and the mice were treated with swimming and downhill running for 8 weeks. Their body weights were obtained using an electronic scale. Their bone length and wet weights were measured by Vernier callipers and an electronic balance. The bone microstructure of the distal femur was analysed by Alizarin red staining of paraffin sections and micro-CT. An ALP dye was used to detect the changes in ALP activity in the mouse skull and osteoblasts. Alizarin red staining was applied to stain the osteoblasts produced by BMSCs. The mRNA expression of related factors were detected by RT-PCR. Our results showed that the body weights of T2DM mice were significantly increased by exercise. When the Wnt3a/β-catenin pathway in the bones of T2DM mice is inhibited, their bone formation ability is significantly reduced, resulting in the degradation of the bone tissue morphology and structure. Except for the significant increase in body weight and Runx2 mRNA expression, swimming had no significant effect on bone formation-related indicators in T2DM mice. However, downhill running could significantly increase their body weight, while the tibia length, wet weight, and the trabecular morphological structure of the distal femur and the indexes of bone histomorphology were significantly improved by activating the Wnt3a/β-catenin pathway. Compared with swimming, downhill running can activate the Wnt pathway to improve bone formation ability, thereby improving bone histomorphology. These findings suggest that exercise promotes OB differentiation, osteogenic capacity and enhances bone formation metabolism by regulating Wnt3a/β-catenin signalling in T2DM mice.
Prolonged Loss of Consciousness in Parkinson’s Disease
Authors: Morimatsu Mitsunori 
Published: May 2021

Abstract
Background: Loss of consciousness is fairly common in Parkinson’s disease (PD), which occurs as syncope associated with postural hypotension based on autonomic dysfunction, or as sleep disorder which consists of excessive daytime sleepiness (EDS) and sleep attacks. In my experience, prolonged loss of consciousness lasting for several hours that is neither EDS nor ordinary sleep attacks can occur in PD patients and indeed seems to be a symptom unique to PD.Case presentation: Eight patients with PD are reported who showed episodes of loss of consciousness lasting for 4-24 h that appeared to be deep sleep or a coma, and could not be roused even by strong painful stimuli. After four hours or more, they spontaneously resumed consciousness without sequelae.Discussion and conclusions: According to the International Classification of Sleep Disorders - Third edition (ICSD-3), “hypersomnia due to a medical disorder,” a synonym of EDS, and “narcolepsy, type 2”, a synonym of sleep attacks are the representatives of sleep disorder in PD. However, the diagnostic criteria of these two disorders in ICSD-3 differ from the prolonged loss of consciousness in my cases. As it has brought great concern to family members, medical staff, and emergent hospital personnel, we must pay more attention to this type of loss of consciousness.
Effect of Level of Sensitization on Gait in Chronic Low Back Pain: Insights from a Machine Learning Approach
Authors: Zheng Xiaoping , Reneman Michiel , Echeita Jone Ansuategui , Preuper HR Schiphorst , Kruitbosch Herbert , Otten Egbert , Lamoth Claudine 
Published: May 2021

Abstract
Background: Despite central sensitization (CS) often presents in patients with chronic low back pain (CLBP), there is a lack of quantitative and qualitative analysis of the effect of CS on gait performance. The study aimed to investigate the daily-living gait performance of patients with CLBP with low and high CS levels (CLBP- and CLBP+, respectively). Method：Forty-two patients with CLBP were included. CS was assessed by Central Sensitization Inventory (CSI). Patients were classified according to low or high CSI score (23 CLBP- and 19 CLBP+). Patients wore a 3D accelerometer for about one week. From each patient, 4 days of accelerometer-data were randomly selected. For each day data, continuous gait cycles were extracted using a Fast Fourier Transform-based and a zero-cross method. For all gait cycles in one day, 36 gait outcomes representing variables related to pace, regularity, smoothness, local stability and predictability of gait were calculated. A Random Forest classifier was trained to classify CLBP- and CLBP+ groups based on gait outcomes and SHapley Additive exPlanations (SHAP) method was used to explain the differences between groups in gait outcomes. Results：The Random Forest classifier could accurately recognize the CLBP- and CLBP+ groups (accuracy = 84.4%, F1-score = 82.6%). SHAP reported that the most differences between CLBP- and CLBP+ groups were: index of harmonicity-vertical and harmonic ratio-mediolateral (gait smoothness), stride frequency variability- mediolateral/anteroposterior, stride length variability (gait variability), stride regularity-mediolateral (gait regularity), maximal Lyapunov exponent-vertical/mediolateral and maximal Lyapunov exponent per stride-vertical (gait stability), and sample entropy-anteroposterior (gait predictability). Conclusions： CLBP- and CLBP+ presented different motor control strategies. CLBP- presented a more “loose” control, including higher gait smoothness and stability. CLBP+ presented a more “tight” control, including a more regular, less variable and more predictable gait pattern.
The long noncoding RNA ADIPINT is a gatekeeper of pyruvate carboxylase function regulating human fat cell metabolism
Authors: Kerr Alastair , Kwok Kelvin , Ludzki Alison , Langin Dominique , Dahlman Ingrid , Arner Peter , Gao Hui 
Published: May 2021

Abstract
The pleiotrophic function of long noncoding RNAs (lncRNAs) is well recognized, but their direct role in regulating metabolic homeostasis is less understood. Here, we describe a human adipocyte-specific lncRNA, ADIPINT, which regulates pyruvate carboxylase (PC) an enzyme pivotal to lipid/carbohydrate metabolism. With a novel approach, Targeted RNA-protein identification using Orthogonal Organic Phase Separation (TROOPS), we show that ADIPINT binds to PC in vivo. ADIPINT knockdown alters the mitochondrial interactome of the enzyme leading to reduced activity. Decreases in ADIPINT levels reduces adipocyte lipid synthesis and breakdown as well as cellular bioenergetics. In human white adipose tissue, ADIPINT expression is increased in obesity and linked to insulin resistance. Changes in ADIPINT expression tightly correlate with adipose PC activity and variations in fat cell size, insulin sensitivity or the amount of adipose tissue. Thus, we identify ADIPINT as an important regulator of lipid and energy metabolism in human white adipocytes.
Efectos a un año de un programa educativo en el control metabólico de pacientes con diabetes de un servicio especializado en un hospital nacional peruano
Authors: Paz-Ibarra José Luis , Alatrista García Cesar 
Published: May 2021

Objetivo: determinar los efectos en el control de la diabetes durante un año de seguimiento de un grupo de pacientes que recibieron un programa educativo añadido al tratamiento habitual en la consulta ambulatoria especializada del Hospital Nacional “Edgardo Rebagliati Martins” en Perú.
Metodología: estudio cuasiexperimental en el que se distribuyeron 90 pacientes en dos grupos: intervención o control. El primero recibió cuatro sesiones educativas en grupos de cinco a ocho participantes. Se procuró que la terapia farmacológica se mantuviera sin modificaciones significativas tres meses antes y durante todo el seguimiento. Se determinaron los cambios en los parámetros clínico-bioquímicos principalmente HbA1c al inicio, a los seis y 12 meses después de la intervención.
Resultados: todos los pacientes completaron todas las sesiones, así como las consultas de seguimiento con la respectiva toma de muestras para la determinación de los parámetros bioquímicos. En el grupo de intervención la HbA1c disminuyó 1,2 % a los 12 meses, mientras el grupo control presentó un incremento de 0,5 %. El peso, la glicemia en ayunas y el colesterol LDL también disminuyeron durante el seguimiento; el porcentaje de pacientes que alcanzaron las metas de HbA1c aumentó en 22 % y de LDL en 11 % a los 12 meses de seguimiento.
Conclusiones: un programa de educación diabetológica añadido al manejo convencional especializado en un hospital nacional de referencia mejoró el control metabólico durante un año de seguimiento.
Consumo e Sustentabilidade em Turismo: panorama, conceitos e métodos aplicados no contexto de pesquisas no Brasil
Authors: Da Silva Melo Sonia Rebouças , Da Silva Minelle Enéas , Sales Melo Francisco Vicente 
Published: May 2021

Os conceitos de consumo associados à sustentabilidade geralmente são múltiplos, porém imprecisos e com pouco consenso. No contexto de pesquisas em turismo, isso se torna ainda mais evidente, uma vez que esta área do conhecimento exige um pensamento multidisciplinar. Com foco no conceito de consumo sustentável, o objetivo central deste artigo é compreender como consumo e sustentabilidade são utilizados em pesquisas na área do turismo. Para tanto, foi realizada uma revisão sistemática da literatura de 71 publicações acadêmicas brasileiras no período de 2008 a 2017. Os resultados revelaram que o conceito de consumo utilizado na área de turismo em estudos sobre sustentabilidade tende a ser amplo e, comumente, a definição aborda mais aspectos ambientais e econômicos. Observa-se que nas pesquisas considerando a perspectiva prática da preservação, há uma tendência a não considerar os turistas como agentes desse processo de preservar, isso porque o consumo, nesse contexto, normalmente está voltado para análise das escolhas que as pessoas fazem ao decidirem por um bem ou serviço. Nesse sentido, a ideia de associar o ato de consumir às práticas de sustentabilidade nas destinações é uma das principais propostas para agenda de pesquisas da área.
Palavras-chave: Consumo Sustentável. Turismo. Sustentabilidade em Turismo. Publicações Nacionais.
Ensino superior em hotelaria: relação entre formação profissional e prática no mercado de trabalho
Authors: Lins Silva Amanda , Menezes Paula Dutra Leão de 
Published: May 2021

O tema educação e trabalho no ensino superior vêm se aproximando em decorrência do reconhecimento das questões inerentes a formação profissional recebida e a adequação com o cotidiano de trabalho. Dessa forma, destaca-se a necessidade de compreender se a formação recebida pelos bacharéis em hotelaria está cumprindo seus propósitos e, ao mesmo tempo, fornecer subsídios para a entendimento da relação entre formação profissional e prática profissional. O presente estudo analisou a relação entre a formação do profissional e prática de mercado de trabalho na perspectiva dos egressos do curso de hotelaria da Universidade Federal da Paraíba. Para tanto, realizou-se uma pesquisa qualitativa descritiva. Para a coleta de dados realizou-se entrevista de Grupo Focal com egressos do curso de hotelaria da UFPB que estão atualmente inseridos no mercado de trabalho em hotelaria. Os egressos expuseram que o curso melhorou com o novo projeto pedagógico de curso e, que atualmente, está caminhando para encontrar uma identidade e avaliam que a transferência do curso do campus de Mamanguape para João Pessoa, bem como a criação do Departamento de turismo e Hotelaria contribuiu para a formação de uma identidade. Segundo os entrevistados faltou na formação mais aspectos relacionados a parte operacional e, sobretudo a prática, elencando como o ponto mais negativo a ausência de laboratórios no curso. Em relação a formação profissional e o mercado de trabalho afirmaram que foi distante, e explicaram que o setor está em crise, que são muitas as mudanças no contexto do mercado e das novas tendências.
Palavras-chave: Ensino Superior. Formação Profissional. Hotelaria.
Fuscoporia valenzuelae (Hymenochaetaceae, Basidiomycota), una especie nueva del bosque tropical caducifolio en México
Authors: Raymundo Tania 
Published: May 2021

Antecedentes y Objetivos: El género Fuscoporia se caracteriza por basidiomas resupinados a pileados, sistema hifal dimítico con hifas generativas hialinas con cristales incrustados, setas hifales, setas himeniales, basidiosporas subglobosas, elipsoides o (sub)cilíndricas. Presenta distribución cosmopolita y en México se han registrado 16 especies. El objetivo de este trabajo es describir e ilustrar a Fuscoporia valenzuelae como especie nueva para el bosque tropical caducifolio en México.
Métodos: Los especímenes se recolectaron en el bosque tropical caducifolio de las Reservas de la Biosfera Chamela-Cuixmala y Sierra Álamos-Río Cuchujaqui. Se registraron los datos de campo y las características morfológicas de acuerdo con las técnicas tradicionales en la micología. Los especímenes se encuentran depositados en el herbario ENCB de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional.
Resultados clave: Se describe a Fuscoporia valenzuelae, una especie nueva que se caracteriza por basidiomas resupinados grandes de hasta 1.5 m de longitud, himenóforo con poros angulares a irregulares de 1-2 por mm, setas hifales y setas himeniales presentes; basidiosporas elipsoides. Crece sobre Astronium graveolens, causando pudrición blanca.
Conclusiones: Fuscoporia con 17 especies es el taxón mejor representado de Hymenochaetaceae en México. Fuscoporia valenzuelae se distribuye en el bosque tropical caducifolio de la Planicie Costera del Pacífico.
PETA PENAKLUKAN WILAYAH BAGIAN TIMUR PULAU JAWA OLEH BELANDA BERDASARKAN TEKS BABAD BASUKI
Authors: Nurhayati, M.Pd. Endang , Dwiadmojo Ghis Nggar 
Published: May 2021

Salah satu genre naskah Jawa yaitu babad. Babad adalah sejarah tradisional Jawa. data penelitian ini adalah data kualitatif. Data kualitatif dalam penelitian ini berupa teks Babad Basuki dalam naskah Babad Basuki dan Bandawasa (BBB) koleksi PNRI dengan nomor koleksi KBG 333. Tujuan penelitian ini adalah mendeskripsikan naskah BBB KBG 333, meringkas cerita penaklukan wilayah dalam teks Babad Basuki, dan membuat peta penaklukan wilayah berdasarkan teks Babad Basuki. Metode yang digunakan adalah pembacaan secara heuristik dan hermeneutik. Wilayah-wilayah yang ditaklukkan Belanda dalam teks adalah Banger, Senthong, Lumajang, Penarukan, Blambangan, Nusa, Klathakan, dan Watu Ula. Teks disalin pada abad ke 19. Berdasarkan teks, daerah-daerah tersebut dulunya merupakan wilayah yang penting untuk ditaklukkan tetapi sekarang menjadi nama kabupaten, kecamatan, kelurahan atau dusun. Kata Kunci: Peta, Penaklukan, Babad Basuki. MAP OF CONQUEST OF THE EASTERN PART OF JAVA BY THE DUTCH BASED ON THE TEXT OF BABAD BASUKI ABSTRACTOne of Javanese manuscript’s genre is babad. Babad is a traditional Javanese history. This research’s data is qualitative data. Qualitative data in this research was Babad Basuki text in the Babad Basuki and Bandawasa (BBB) handscripts. This handscripts is PNRI collection with KBG 333 collection number. The purpose of this study were to describe the KBG 333 BBB manuscript, summarize the story of regional conquest in Babad Basuki text, and make map territorial conquests based on the text of Babad Basuki. The method used are heuristic and hermeneutic reading. The territories conquered by the Dutch in the text were Banger, Senthong, Lumajang, Penarukan, Blambangan, Nusa, Klathakan, and Watu Ula. The text was copied in the 19th century. Based on the text, these areas were once important areas to be conquered but now become names of town, district, village, and sub-village. Keywords: Peta, Conquest, Babad Basuki.
DEMOKRASI ESTETIKA DALAM PUISI “SONG OF MYSELF” KARYA WALT WHITMAN
Authors: Rujito Eko 
Published: May 2021

(Title: Aesthetic Democracy in the Poetry of “Song Of Myself” by Walt Whitman). American poet Walt Whitman is widely considered the father of American modern poetry because of his revolutionary concept of poetry writing. Whitman is a (political) thinker as much as a poet, and most notably, a democratic prophet. Through his abundant essays and poems, he preaches what he refers as aesthetic democracy. Employing descriptive-qualitative method, this paper aims at investigating the application of this concept in Whitman’s most famous poem “Song of Myself”. The result of the analysis shows that Whitman presents the concept of democracy of aesthetic in the both form and the content of the poem. The form of the poem signifies Whitman’s rejection to the old poetic conventions and his aspiration of a more democratic poetic. The content of the poem shows a democratic tendency by involving various themes, subjects and personae with no privilege and subordination towards particular themes, subject or personae.Keywords: aesthetic democracy, Whitman, “Song of Myself”
REPRESENTING OTHERS CARL THOMPSON DALAM NOVEL TRAVELER’S TALE: BELOK KANAN BARCELONA
Authors: Prastowo Galang , Wijaya Ikha Adhi 
Published: May 2021

(Title: Representing Others Carl Thompson in The Novel “Traveler’s Tale: Belok Kanan Barcelona”). This research appllied representing other Carl Thomson approach in a novel entitled Traveler’s Tale: Belok Kanan Barcelona. Representing other in the mentioned novel was conducted to expound on how the writer portrays west and east culture as the travel writing. The writer applied Carl Thompson’s Theory to indentifying Travelers Tale novel; Belok Kanan Barcelona from the representing other’s concept trough descriptive and qualitative approach. The research result has shown that they appraise the west culture than the east culture - tend to belittle the east culture. The revealing of the two differnt culture features is represented in a form of idiology in travel writing. Ergo, from this research, we can conclude that the writing technique tends to exergerating the west (self), the comparison result tends to belittle the east culture (others). Keywords: travel writing, representing other, carl thompson.