bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Changes in Corneal Biomechanical Properties before and After Photorefractive Keratectomy and Small Incision Lenticule Extraction
Authors: Mokhtar Amal Shaban Mohamed , Ghonem Ahmed Mohamed , Nagy Khaled Ahmed , Nassar El Sayed Abbas 
Published: November 2021

Background: Corneal biomechanics is the study of the mechanical properties and responses of the cornea to external forces. Two devices are currently available for characterizing the corneal biomechanical properties in a clinical setting; Ocular Response Analyzer (ORA) (Reichert, Buffalo, New York, USA) based on bidirectional applanation tonometry and Corvis -ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) based on corneal deformation estimation using Scheimpflug imaging. Ocular response analyzer was used to assess corneal hysteresis (CH) and corneal resistance factor (CRF) to characterize changes in corneal biomechanics.
The other device is Corvis –ST which produces air pulse on the cornea then measures and records the movements using a high-speed Scheimpflug video camera in real time. It is highly sensitive and specific to differentiate healthy cornea from keratoconic one.
Aim: The aim of our study is to compare the changes in corneal biomechanical properties before and after PRK and SMILE.
Patients and Methods: This is a prospective comparative study and included 20 patients who had undergone PRK by Allegretto wave eye-Q device & 20 patients who had undergone SMILE by Visumax Ziess device.
Results: The significant difference between two groups at 6 months after surgery considering IOPb=0.027*. Integ. Radius=0.001*. SPA1=0.003*. This difference makes Femto SMILE better than PRK procedure for more stability of the corneal biomechanics and possibly lowers the incidence of postoperative ectasia.
Conclusion: According to CORVIS-ST for corneal biomechanical evaluation, the significant difference between two groups at 6 months after surgery considering IOPb=0.027*. Integ. Radius=0.001*. SPA1=0.003*. This difference makes SMILE better than PRK procedure for more stability of the corneal biomechanics and possibly lowers the incidence of postoperative ectasia.
Dialogue between social movement activists and a Master's Program in youth and adult education
Authors: Costa Graça Dos Santos , Costa Patricia Lessa Santos , Santos Carla Liane Nascimento Dos , Mallows David 
Published: November 2021

AbstractThis article presents the results of a qualitative study on the relationship between social movements and a Master's Program in youth and adult education in Bahia, Brazil. It pays particular attention to the importance of antiracism in and the decolonization of the program's curriculum.
Self‐Delivery Nanomedicine for Glutamine‐Starvation Enhanced Photodynamic Tumor Therapy
Authors: Zhao Lin‐Ping , Chen Shao‐Yi , Zheng Rong‐Rong , Kong Ren‐Jiang , Rao Xiao‐Na , Chen A‐Li , Cheng Hong , Zhang Da‐Wei , Li Shi‐Ying , Yu Xi‐Yong 
Published: November 2021

AbstractGlutamine metabolism of tumor cells plays a crucial role in maintaining cell homeostasis and reducing oxidative damage. Herein, a valid strategy of inhibiting glutamine metabolism is proposed to amplify the oxidative damage of photodynamic therapy (PDT) to tumor cells. Specifically, the authors develop a drug co‐delivery system (designated as CeV) based on chlorine e6 (Ce6) and V9302 via the self‐assembly technology. In spite of the strong hydrophobicity of therapeutic agents, the assembled CeV holds a favorable dispersibility in water and an improved cellular uptake capability. Under light irradiation, the internalized CeV is capable of generating abundant reactive oxygen species (ROS) for PDT. More importantly, CeV can reduce the uptake of glutamine through V9302‐mediated alanine‐serine‐cysteine transporter of type‐2 (ASCT2) inhibition, leading to a reduced glutathione (GSH) production and an amplified oxidative stress. As a result, CeV has a robust PDT efficacy on tumor inhibition by the blockade of glutamine transport. Notably, CeV exhibits a superiority on tumor suppression over the single treatment as well as the combined administration of Ce6 and V9302, which indicates the advantage of CeV for synergistic treatment. It may serve as a novel nanoplatform for developing a drug co‐delivery system to improve PDT efficiency by inhibiting cell metabolism.
Differences in the vertical components of substrate reaction forces between two modes of infant carrying in Japanese macaques (Macaca fuscata fuscata)
Authors: Goto Ryosuke , Yamada Kazunori , Nakano Yoshihiko 
Published: November 2021

AbstractObjectivesJapanese macaque mothers carry their infants ventrally (VC) or dorsally (DC). As the infant weight increases, the dominant mode of infant carrying transitions from VC to DC. We biomechanically tested the hypothesis that the transition is associated with relieving vertical components of substrate reaction forces (SRFvrts) acting on the forelimbs, as macaques prefer to support their body weight mainly using the hindlimbs. The test is based on two expectations: (1) during VC, higher SRFvrts act on the forelimbs, and (2) SRFvrts during DC do not significantly differ from those of a control condition in which the mother walked alone.Materials and methodsTwo female Japanese macaques rearing 1‐year‐old infants were used for terrestrial locomotor experiments, and five females were used for arboreal experiments. We collected the SRFvrts acting on the fore‐ and hindlimbs at midstance when the macaques walked on the ground and pole and statistically compared the values among the control condition, VC, and DC.ResultsHigher relative SRFvrts normalized by the total weights of the mother and infant acted on the forelimbs during VC compared with the control condition and DC, regardless of the substrate type. The relative forelimb SRFvrts during DC exhibited similar values to those during the control condition.DiscussionThe transition to DC could relieve the excessive loads acting on the forelimb. Despite the biomechanical costs of VC, the carriage mode has evolved in the order primates likely because VC might enable the mother to protect her infant from predators.
DICE: A Bayesian model for early dose finding in phase I trials with multiple treatment courses
Authors: Ursino Moreno , Biard Lucie , Chevret Sylvie 
Published: November 2021

AbstractDose‐finding clinical trials in oncology aim to determine the maximum tolerated dose (MTD) of a new drug, generally defined by the proportion of patients with short‐term dose‐limiting toxicities (DLTs). Model‐based approaches for such phase I oncology trials have been widely designed and are mostly restricted to the DLTs occurring during the first cycle of treatment, although patients continue to receive treatment for multiple cycles. We aim to estimate the probability of DLTs over sequences of treatment cycles via a Bayesian cumulative modeling approach, where the probability of DLT is modeled taking into account the cumulative effect of the administered drug and the DLT cycle of occurrence. We propose a design, called DICE (Dose‐fInding CumulativE), for dose escalation and de‐escalation according to previously observed toxicities, which aims at finding the MTD sequence (MTS). We performed an extensive simulation study comparing this approach to the time‐to‐event continual reassessment method (TITE‐CRM) and a benchmark. In general, our approach achieved a better or comparable percentage of correct MTS selection. Moreover, we investigated the DICE prediction ability.
Influences on the structural response of beams in drop tower experiments
Authors: Leicht Lena , Beckmann Birgit , Curbach Manfred 
Published: November 2021

AbstractDrop tower tests on beam specimens were carried out to evaluate the influence of different geometric features and different loading velocities on the beams' response. Tested geometric characteristics are stirrup reinforcement in addition to longitudinal reinforcement, and notches. The goal is to quantify the differences in the global behavior and the amount of strains and strain rates measured at different positions on the reinforcement. This gives an insight into strain distributions along the rebars from which bond stresses can be derived. It can be stated that stirrup reinforcement kept the specimens together and thus increased the impact resistance. That was seen in the deflection and acceleration measurements, but it was also suggested by strain measurements, especially looking at residual strains. The maximum strains are generally more affected by global bending of the specimens than by the formation of a localized punching cone, which was the main failure mode.
Nuclear Factor I in neurons, glia and during the formation of Müller glia‐derived progenitor cells in avian, porcine and primate retinas
Authors: El‐Hodiri Heithem M. , Campbell Warren A. , Kelly Lisa E. , Hawthorn Evan C. , Schwartz Maura , Jalligampala Archana , McCall Maureen A. , Meyer Kathrin , Fischer Andy J. 
Published: November 2021

AbstractThe regenerative potential of Müller glia (MG) is extraordinary in fish, poor in chick and terrible in mammals. In the chick model, MG readily reprogram into proliferating Müller glia‐derived progenitor cells (MGPCs), but neuronal differentiation is very limited. The factors that suppress the neurogenic potential of MGPCs in the chick are slowly being revealed. Isoforms of Nuclear Factor I (NFI) are cell‐intrinsic factors that limit neurogenic potential; these factors are required for the formation of MG in the developing mouse retina and deletion of these factors reprograms MG into neuron‐like cells in mature mouse retina. Accordingly, we sought to characterize the patterns of expression of NFIs in the developing, mature and damaged chick retina. In addition, we characterized patterns of expression of NFIs in the retinas of large mammals, pigs and monkeys. Using a combination of single‐cell RNA‐sequencing (scRNA‐seq) and immunolabeling, we probed for patterns of expression. In embryonic chick, levels of NFIs are very low in early E5 (embryonic day 5) retinal progenitor cells (RPCs), upregulated in E8 RPCs, further upregulated in differentiating MG at E12 and E15. NFIs are maintained in mature resting MG, microglia and neurons. Levels of NFIs are reduced in activated MG in retinas treated with NMDA and/or insulin+FGF2, and further downregulated in proliferating MGPCs. However, levels of NFIs in MGPCs were significantly higher than those seen in RPCs. Immunolabeling for NFIA and NFIB closely matched patterns of expression revealed in different types of retinal neurons and glia, consistent with findings from scRNA‐seq. In addition, we find expression of NFIA and NFIB through progenitors in the circumferential marginal zone at the far periphery of the retina. We find similar patterns of expression for NFIs in scRNA‐seq databases for pig and monkey retinas. Patterns of expression of NFIA and NFIB were validated with immunofluorescence in pig and monkey retinas wherein these factors were predominantly detected in MG and a few types of inner retinal neurons. In summary, NFIA and NFIB are prominently expressed in developing chick retina and by mature neurons and glia in the retinas of chicks, pigs and monkeys. Although levels of NFIs are decreased in chick, in MGPCs these levels remain higher than those seen in neurogenic RPCs. We propose that the neurogenic potential of MGPCs in the chick retina is suppressed by NFIs.
Does previous history of cancer or atypia predict histologic upgrade for pure intraductal papillomas diagnosed via core biopsy? A study of 490 cases at a single institution
Authors: Alberty‐Oller J. Jaime , Reyes Sylvia , Moshier Erin , Ru Meng , Weltz Sarah , Santos Antonio , Pisapati Kereeti , Port Elisa , Jaffer Shabnam 
Published: November 2021

AbstractBackgroundManagement of pure intraductal papillomas (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial given highly variable rates of upgrade in the literature.AimWe sought to identify clinical and histologic factors that predict upgrade to atypia or malignancy in a large population.Methods and resultsA retrospective review was performed of all cases of pure IDP diagnosed on CNB and then surgically excised at a single institution from 2008 to 2018. Clinical, radiologic, and pathologic factors were compared in the no upgrade, upgrade to atypia, or upgrade to cancer groups. Univariate analysis was performed comparing no upgrade and upgrade to cancer or atypia.Four hundred and thirty nine patients were identified with a total of 490 IDP and a median age of 50 years (range 16–85). Of these patients, 54 (12.3%) were upgraded to atypia after surgical excision and five (1.1%) were upgraded to cancer. The presence of multiple papillomas in a single patient was a significant predictor of upgrade to cancer or atypia (p < .01), as well as age over ≥55 years (p < .01) and a prior history of cancer (p < .01). No other clinical, radiologic and histologic factors were found to be significant predictors of upgrade. 40/439 (9.1%) patients in the total cohort had prior history of cancer, and of these, 2/40 (5%) were found to have a new cancer after excision.ConclusionsIn patients with pure IDP on CNB, the upgrade rate to malignancy was 1.1%, while 12.3% were upgraded to atypia. The clinical significance of identifying atypia in a papilloma is unknown, especially in a patient with a prior history of atypia or cancer. However, the majority of patients who were upgraded to either atypia or cancer had no prior history of high‐risk or malignant breast disease and are therefore considered true clinical upgrades. As such excision for IDP should be considered.
Gray wolf optimization‐based optimal grid connected solar photovoltaic system with enhanced power quality features
Authors: Nagadurga T. , Narasimham P. V. R. L. , Vakula V. S. , Devarapalli Ramesh 
Published: November 2021

AbstractIn recent times, regional renewable energy sources (RES) are increasingly integrated with the existing electric power grid by onboarding certain superior power quality features, thereby helping them in meeting massive electrical demand. This grid integration drastically reduces the use of fossil fuels, besides preventing environmental hazards as well. However, in grid‐connected systems, with RES such as photovoltaic (PV) systems and wind energy systems, many power quality issues (PQ) still crop up. In this paper, Gray Wolf Optimization (GWO), in conjunction with a static synchronous compensator (STATCOM) is suggested to address such challenges in the RES integrated grid‐connected PV systems. The intermittent nature of solar PV power under shading conditions can be harnessed by using the GWO approach. STATCOM is one of many specialized power electronic devices that effectively reduce power quality concerns such as voltage sag/swell and Total Harmonic Distortions. The fast‐acting PI controller is intended to drive a STATCOM by using some tuned parameters for maintaining the DC link voltage as constant. The best findings are attained after these results are compared with PI. The test system is modeled using the MATLAB/Simulink environment.
Single‐objective service composition methods in cloud manufacturing systems: Recent techniques, classification, and future trends
Authors: Hayyolalam Vahideh , Pourghebleh Behrouz , Chehrehzad Mohammad Reza , Pourhaji Kazem Ali Asghar 
Published: November 2021

AbstractIn recent years, cloud manufacturing (CMfg) has been developed as an intelligent manufacturing system, in which geographically distributed manufacturing resources are available as services in the cloud platform. Choosing and integrating single services into a combined service to fulfill the client's requests requires higher emphasis. However, by increasing customers' trend to utilize CMfg, service providers are encouraged to publish services with various functional and non‐functional characteristics. Thus, service composition and optimal selection has become one of the most challenging topics in CMfg. Hence, an inclusive review of current studies on this NP‐hard issue is extremely desirable. This article first, selects the recent studies in the field of single‐objective service composition in CMfg and classifies and surveys them comprehensively in terms of QoS parameters, energy consumption, user constraint, and so forth. This article aims to provide a useful roadmap for future researchers who are intended to explore novel work in this field. The search for articles was conducted in November 2020.
Optical and Thermal Properties of Acid Red Doped Triglycine Acetate Crystal for Optoelectronic Applications
Authors: Chaithra G. , Deepthi P. R. , Challa Malathi , Sukhdev Anu , Kumar P. Mohan , Shanthi J. 
Published: November 2021

AbstractA positive change in crystal can be induced by dye. Pure and Acid Red 1 dye (AR) doped triglycine acetate (TGAc) single crystals are synthesized by solution approach to enrich the characteristics of pure TGAc crystals. The crystalline nature of the grown crystals is investigated using powder X‐ray diffraction. The Scherrer method has been used to calculate the crystallite size of both developed crystals and is compared to the Williamson and Hall method. Fourier transform infrared spectroscopy confirms the existence of several functional groups as well as dye inclusion in the produced crystals. Four distinct absorption bands are found in UV–vis–NIR absorption spectra at the location where AR dye is inserted into the TGAc matrix. Different optical constants, such as optical bandgap (Eg), extinction coefficient (k), refractive index (n) and optical conductivity (σ) are measured for both samples based on transmittance measurements. The thermal stability and decomposition temperature of 0.05 mol% AR dye doped TGAc are found to be higher. The doped crystals' improved optical characteristics and thermal stability prove their applicability for optoelectronic applications.
Periodontal status and the efficacy of the first‐line treatment of major depressive disorder
Authors: Jelavić Silvana , Bajić Žarko , Filipčić Ivona Šimunović , Čulina Ivana Jurčić , Filipčić Igor , Aurer Andrej 
Published: November 2021

AbstractObjectivesThe efficacy of treatment of major depressive disorder (MDD) is not satisfactory. Systemic inflammation may play an important role in MDD pathogenesis and treatment outcomes. Periodontal disease is the systemic inflammatory condition. Its prevalence may be as high as 45%. We aimed to assess the association of periodontal status with the outcome of 3‐month first‐line treatment of MDD with selective serotonin reuptake inhibitors.Material and MethodsWe performed the prospective cohort study during 2018/2019 at Psychiatric Hospital “Sveti Ivan,” Croatia, on a consecutive sample of 43 patients. The outcome was the MDD symptoms severity measured using the Hamilton Depression Rating Scale‐17. The periodontal status was indicated by the clinical attachment loss (CAL).ResultsBaseline periodontal status had a nonlinear significant and clinically relevant association with the MDD treatment outcome (R2 change of the quadratic term = 0.12; p = 0.027). In patients with good baseline periodontal status the severity of MDD symptoms was significantly improved. When the value of CAL was ≥4.44 mm, indicating the worse periodontal status, further increase in baseline CAL was associated with the worsening of MDD treatment outcomes independently of the baseline depression severity and 14 sociodemographic and clinical predictors of treatment outcome.ConclusionsPeriodontal healthcare is accessible, and should be utilize in an integrative, multidisciplinary approach not only for the sake of psychiatric patients' quality of life and prevention of periodontal disease, but for the sake of the outcomes of psychiatric treatment as well.
Current and future distribution of the deciduous shrub Hydrangea macrophylla in China estimated by MaxEnt
Authors: Yan Xingyue , Wang Shuchen , Duan Yu , Han Jing , Huang Donghua , Zhou Jian 
Published: November 2021

AbstractClimate change has a significant impact on the growth and distribution of vegetation worldwide. Hydrangea macrophylla is widely distributed and considered a model species for studying the distribution and responses of shrub plants under climate change. These results can inform decision‐making regarding shrub plant protection, management, and introduction of germplasm resources, and are of great importance for formulating ecological countermeasures to climate change in the future. We used the maximum entropy model to predict the change, scope expansion/reduction, centroid movement, and dominant climate factors that restrict the growth and distribution of H. macrophylla in China under current and future climate change scenarios. It was found that both precipitation and temperature affect the distribution of suitable habitat for H. macrophylla. Akaike information criterion (AICc) was used to select the feature combination (FC) and the regularization multiplier (RM). After the establishment of the optimal model (FC = QP, RM = 0.5), the complexity and over‐fitting degree of the model were low (delta AICc = 0, omission rate = 0.026, difference between training and testing area under the curve values = 0.0009), indicating that it had high accuracy in predicting the potential geographical distribution of H. macrophylla (area under the curve = 0.979). Overall, from the current period to future, the potential suitable habitat of this species in China expanded to the north. The greenhouse effect caused by an increase in CO2 emissions would not only increase the area of high‐suitability habitat in Central China, but also expand the area of total suitable habitat in the north. Under the maximum greenhouse gas emission scenario (RCP8.5), the migration distance of the centroid was the longest (e.g., By 2070s, the centroids of total and highly suitable areas have shifted 186.15 km and 89.84 km, respectively).