bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal cell carcinoma of the lower eyelid is an actinic-induced cancer: The ABCDE concept to explain the relationship between the invasiveness of basal cell carcinoma and actinic damage
Authors: Minussi Luiza Abreu , Sakabe Felipe Key , Barin Roxana , Marcotte Emily , Abreu Elvira Barbosa , Burnier Miguel Noel 
Published: December 2024

Abstract

Purpose:
Basal cell carcinoma (BCC) originates from the basal cells in the epidermis and is particularly prevalent on the eyelid. Ultraviolet (UV) radiation, a key factor in BCC development, induces fibroblast actinic damage and abnormal elastic fiber deposition, leading to cancer development. This study investigates the relationship between UV radiation and BCC on the lower eyelid by examining the incidence and characteristics of this cancer across diverse geographic regions.

Materials and Methods:
A cohort of 813 BCC eyelid patients from Canada was analyzed. Tumor locations (lower vs. upper eyelid) were recorded. The histopathological evaluation included 707 lower eyelid BCC cases and 493 benign lesions of the lower eyelid. Actinic damage was graded on a scale of 0–3. The presence of in situ BCC was assessed.

Results:
Results revealed a consistent trend: 87% of Canadian BCC cases occurred on the lower eyelid. Severe actinic damage was observed in 89% of pathological lesions, with 11% showing moderate damage. In contrast, 93% of benign lesions had no detectable actinic damage, whereas 7% showed mild damage. Notably, no BCC cases were in the in situ phase, indicating advanced disease upon diagnosis.

Conclusion:
These findings confirm that BCC of the lower eyelid is primarily induced by UV radiation exposure. Actinic damage in fibroblasts leads to DNA alterations in dermal fibroblasts and is the hallmark feature in sclerosing BCC. This highlights the critical role of UV-induced genetic damage in the pathogenesis of lower eyelid BCC, emphasizing the need for preventive strategies.
Effectiveness of low-dose topical atropine in preventing the progression of myopia – A prospective interventional cohort study in pediatric patients
Authors: Mohan Tara Susan , Menon Liji , Shimy Mary , Balan Binu , Panicker Latha 
Published: December 2024

Abstract

Background:
Myopia is a very common pathological condition in the pediatric age group which can lead to devastating complications if not treated early. Recent studies support the use of atropine drops of various concentrations to prevent the progression of myopia in children. Not many studies have been published from India in this regard.

Aims and Objectives:
We attempt to assess the effectiveness of low-dose atropine (0.01%) in preventing myopia progression in children.

Materials and Methods:
80 eyes of 40 myopic children who attended our Institute were studied after dividing them into control and test groups and followed up for a period of 1 year.

Results:
Significant reductions in change in axial length and refractive error were noted at the end of 1 year. There is no significant pupillary dilatation with the use of 0.01% atropine and side effects like photophobia were not reported.

Conclusion:
We concluded that atropine sulfate 0.01% is safe and effective in slowing down the progression of myopia.
A cross-sectional study to evaluate ocular manifestations in end-stage renal disease patients attending tertiary care center
Authors: Kaushik D. S. , Ashwini K. V. , Angraje Srivatsa 
Published: December 2024

Abstract

Context:
Chronic renal failure leads to end-stage renal disease (ESRD), where patients rely on hemodialysis (HD). ESRD affects multiple organ systems, including the eyes, there is limited data on ocular complications among HD patients in India.

Aims:
The aim of the study was to analyze the clinical spectrum of ocular manifestations in ESRD patients on HD and investigate the relationship between the duration of dialysis and ocular complications.

Settings and Design:
A hospital-based cross-sectional study was conducted at a tertiary care center involving 75 ESRD patients.

Methodology:
Participants underwent comprehensive ophthalmic examinations, including tonometry and fundus examination. The study excluded patients with corneal dystrophy, renal transplant history, ocular trauma, or malignancy. Data on dialysis duration, frequency, and ESRD etiology were collected.

Statistical Analysis Used:
Nonparametric Mann–Whitney U test assessed the relationship between dialysis duration and ocular complications, with significance set at P < 0.05.

Results:
Among 150 eyes, 83.33% exhibited ocular abnormalities, with cataracts (50%) and conjunctival calcification (16%) being the most common findings. Significant correlations were found between dialysis duration and diabetic retinopathy (P = 0.01), hypertensive retinopathy (P = 0.005), and conjunctival calcification (P = 0.012).

Conclusions:
Ocular abnormalities are prevalent in ESRD patients undergoing HD, with dialysis duration significantly associated with specific conditions. Regular ophthalmologic evaluations are essential for managing ocular health in this population.
Postoperative Outcomes among COVID-19-infected Pediatric Patients in a Philippine Tertiary Pediatric Specialty Hospital
Authors: de Mesa Yuri Mikael Garcia , Gamo Allan Benson Abanador 
Published: December 2024

ABSTRACT

Introduction:
Multiple studies in adults have shown that infection with COVID-19 have increased mortality and pulmonary complication rates in postoperative patients. Data comparing the clinical course of adult and pediatric COVID-19 patients showed that the latter had generally a milder course. However, data for outcomes of COVID-19-infected children who underwent surgery are still lacking especially in the local setting.

Materials and Methods:
This is an analytic cross-sectional study that included all COVID-19 pediatric patients who underwent surgery from 2020 to 2022 in a tertiary government hospital. Mortality rate and postoperative pulmonary complications (PPCs) were the primary and secondary outcomes in the study, respectively. Multiple logistic regression analysis was used to determine the factors associated with mortality and PPCs.

Results:
Fifty-five COVID-19 patients were included in the study. PPCs were noted in 22% (n = 12) of patients. One patient (2%) died during the study. Fifty-five percent (n = 30) of patients presented with preoperative pulmonary symptoms and were associated with risk of developing PPCs (adjusted odds ratio [aOR] 3.7 [95% confidence interval 1.27–10.75], P = 0.016). Undergoing a subsequent surgery was also noted to increase risk for PPCs (aOR 29.43 [2.53–342.37], P = 0.007). ASA three patients, patients with allergy, patients needing O2 support and those who were diagnosed with COVID-19 postoperatively were noted to have higher proportions of patients who developed PPCs but were not statistically significant.

Conclusions:
Patients with pulmonary symptoms and patients who underwent another procedure were factors noted to be associated with increased risk of developing PPCs.
Artificial Intelligence Integration and Data Governance in Pharmacy and the Healthcare sector: A Position Statement on Behalf of the Saudi Society of Clinical Pharmacy (SSCP) and the Saudi Health Informatics Pharmacists (SHIP)
Authors: Alshaya Abdulrahman I. , Alowais Shuroug A. , Badreldin Hisham A. , Alqahtani Tariq , Alzeer Abdullah , Alghamdi Hazza , Alomeen Abdulgader , BinDos Amal , Ashmawi Hasan , Joharji Hala , Alawagi Mohammad , Almudaiheem Hajer , Al-jedai Ahmed 
Published: December 2024

Abstract
The Saudi Society of Clinical Pharmacy (SSCP) and the Saudi Health Informatics Pharmacists (SHIP) collaborated to develop a position statement on the integration of artificial intelligence (AI) and data governance in the pharmacy practice and the healthcare sector. The SSCP and the SHIP have established a focused group dedicated to creating a comprehensive overview and formulating the position paper. Through a modified Delphi method of two rounds, the task force developed 12 key recommendations with a≥80% consensus rate covering a wide range of areas, including policy development, regulatory frameworks, education and training, ethical considerations, data governance, and patient privacy, to create an environment that supports the responsible and effective utilization of AI in pharmacy practice. This position statement calls on stakeholders in the pharmacy profession and the healthcare sector to embrace AI as a transformative tool while ensuring that ethical principles, patient safety, and the promotion of optimal healthcare outcomes guide its implementation. The SSCP and SHIP are addressing these crucial aspects as an opportunity for Saudi Arabia to spearhead advancements in AI integration in pharmacy and contribute to the global progress in healthcare innovation.
Cost-Utility Analysis and Comparative Effectiveness Analysis of Biologic Treatment of Moderate-to-Severe Psoriasis in Saudi Arabia
Authors: Hamadah Issam R. , Al Tawil Esraa S. , Alsaqa’aby Mai , AlFada Mohammed A. , Al-Haddab Mohammed A. , Abu-Shraie Nada , Mohamed Omneya , Basu Sujata , Roshdy Ahmed , Rateb Mohamed , Nour Yasser , Al-Sheikh Afaf A. 
Published: December 2024

Abstract

Background:
Psoriasis is a chronic, immune-mediated disease of the skin and joints, with a global prevalence of 2%–3%. Psoriasis area and severity index (PASI) 75 is accepted as a scoring system to evaluate baseline reasonable response to therapy. However, with advent of newer biologics, the PASI90 outcome is now potentially achievable.

Objective:
To assess the cost-utility of achieving PASI75 or PASI90 using risankizumab in psoriasis patients in Saudi.

Materials and Methods:
A Markov model was developed with a 12-week cycle length and 40-year time horizon from a healthcare payer perspective. Costs considered were related to drug acquisition, drug administration, medical resource use, adverse event management, and physician visit costs. The model compared the current treatment sequence anti-tumor necrosis factor alpha (adalimumab), interleukin (IL)12/23 inhibitors (ustekinumab), and IL-17A inhibitor (secukinumab), as the first-, second-, and third-line treatments, respectively, targeting PASI75 versus IL-23 inhibitor (risankizumab) as the first-line treatment option, targeting PASI90.

Results:
Using the current treatment sequence and targeting PASI75 as a clinical outcome, the overall cost of moderate-to-severe psoriasis management in Kingdom of Saudi Arabia was estimated to be 8.9 billion United States Dollar (USD), yielding 921,039 quality-adjusted life-year (QALYs). The average cost and QALY per patient was USD 0.4 million and 23.64, respectively. The use of risankizumab as the 1st line option targeting PASI90 yielded an overall cost of 8.4 billion USD and 951,512 QALYs. The cost savings and the high QALY gain were attributed to the lower healthcare resource utilization and increased probability of achieving PASI90, respectively.

Conclusion:
Targeting PASI90 using risankizumab as a 1st line treatment for moderate-to-severe psoriasis patients was found to be cost-effective.
SYED MUHAMMAD JAUNPURI AS REFORMER OF ISLAM: AN HISTORICAL OVERVIEW
Authors: Riaz Masood , Ahmed Fouzia , Ali Fizza 
Published: December 2024

In 1497, Syed Muhammad Jaunpuri of India claimed to be a reformer with the mission to purify Islam by justifying his claim according to the teachings and sayings of the Prophet of Islam. He started by curbing the innovations, focusing on belief in Allah, offering prayers, search for God and the truth, and also challenging the religious scholars of his time. Thus, he was criticized by religious scholars by refuting Jaunpuri’s claim of being a reformer, interestingly, academicians have also ignored Jaunpuri’s role as a reformer, but this paper discusses the life of Jaunpuri by focusing on his role as a reformer in India, moreover, this paper limits its scope with the life of Jaunpuri as a reformer. The research used a descriptive cum analytical approach which was aimed at making the research a qualitative one and for that various libraries of Pakistan and personal collections of followers of Jaunpuri were accessed, and at the same time, various websites were also surveyed. So, the research resolved that Jaunpuri was a reformer of the 15th century India who did his best to reform the people and society of his time by bringing them closer to their Creator.
THE ROLE OF ASSESSMENTS IN ENHANCING MOTIVATION OF UNIVERSITY STUDENTS’ OF KARACHI
Authors: Khemchand Kavita , Kang Muhammad 
Published: December 2024

The education system of Pakistan has always remained a cause of concern mainly for the educators, stakeholders, ruling political parties, students and parents’ community. A lot of effort has been put to upgrade the education system, increase the literacy rate and maintain the interest and motivation of the learner. One of the main reasons lies in the manner, in which the students are assessed, as assessments are considered to be the means of betterment and improvement. The main aim of the study was to identify the views of university students of Karachi, towards the enhancement of motivation, through assessments. It was a quantitative research, in-person survey was conducted to investigate the role assessment plays in enhancing motivation of students. A 5-point Likert scale questionnaire was constructed, to collect the data from two hundred and fifteen, randomly selected university students of Karachi. Data were analyzed using SPSS version 22. The Psychometric Scale exhibited a positive perception of the construct amongst the respondents. The reliability=.76, with the highest M=4.44, regarding teachers’ attitudes and M=4.44 revealing teachers’ remarks have a deep effect on students’ motivation. Conflicts in the family play a vital role in university students' academic motivation with M=4.34.
THE NEXUS BETWEEN HEALTH CARE SPENDING AND ECONOMIC GROWTH IN SELECTED COUNTRIES IN SUB-SAHARA AFRICA
Authors: Anthony OSOBASE , Joshua OJO , Abiola AJAO 
Published: December 2024

The study investigates the relationship between healthcare spending and economic growth in six selected Sub-Saharan African countries: Nigeria, Ghana, Togo, Benin, Cameroon, and Ethiopia. The study employs the Autoregressive Distributed Lag (ARDL) model as an estimation technique to analyse the panel data which spans from 2000 to 2020. The research examines both the short- and long-run impacts of healthcare spending, population growth, and life expectancy on real GDP (a proxy for economic growth). Based on the ARDL panel results, it is stated that, in the short run, both healthcare spending and life expectancy exert a significant negative impact on real GDP. However, in the long run, real GDP is positively and significantly influenced by all the regressors, highlighting the crucial role of healthcare investment in driving economic development. Additionally, the Granger causality test reveals a bidirectional relationship between real GDP and per capita health spending, suggesting that enhancements in healthcare can stimulate economic growth, and economic growth, in turn, can lead to increased healthcare investments. The study strongly recommends that policymakers in these countries adhere to the Abuja Declaration by allocating 15% of their national budgets to the healthcare sector to bolster economic outcomes. These findings emphasize the critical importance of sustained healthcare investment as a catalyst for long-term economic growth in Sub-Saharan Africa.
Retraction notice to "Indoors Fitness Training Monitoring based on OpenPose" Vol. 6 No. 3 (2024):Journal of Advanced Applied Scientific Research-ICKE-2023
Authors: Joaasr Emanager 
Published: December 2024

Title of the Article: "Indoors Fitness Training Monitoring based on OpenPose"Author(s): J.Haoran, S. Karungaru, & K. Terada
DOI: https://doi.org/10.46947/joaasr632024947
We regret to announce the retraction of the article titled "Indoors Fitness Training Monitoring based on OpenPose" by J.Haoran, S. Karungaru, & K. Terada, which was originally published in volume Vol. 6 No. 3 (2024): JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH-ICKE-2023 on 30-05-2024.
This retraction follows several unresolved issues that arose after publication:

Failure to Provide Valid Justification for Reference Changes: The author(s) requested significant changes to the references in the article but failed to provide the necessary and valid justification for these changes in the required format. Despite multiple requests for clarification, the justification provided was insufficient. Given the importance of proper referencing for the accuracy and credibility of academic work, this issue raised serious concerns.

Image Duplication Detected: During the post-publication review, it was discovered that some images in the article had been duplicated from previously published papers. This raised significant concerns regarding the integrity and originality of the data presented in the publication.

The authors had previously requested retraction of the article if their proposed reference changes were not accepted. Given this request and the issues identified, we have decided to proceed with the retraction of the article.
We sincerely apologize to our readers for any inconvenience caused by this retraction. Our commitment to maintaining the highest standards of scholarly publication remains steadfast, and we will continue to ensure that all content published in JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH adheres to these rigorous standards.
A Comparative Analysis of European Sustainability Reporting Practices: The Role of ESG Standards and SDG's in Enhancing Effectiveness
Authors: Matacera Alessio , Tola Francesco , Tarantino Mariarita , Gianvincenzi Mattia , Mosconi Enrico Maria 
Published: December 2024

Objectives: This paper examines the interoperability between Global Reporting Initiative (GRI) standards and the European Sustainability Reporting Standards (ESRS), focusing on their role in improving corporate transparency and accountability, aligned with the European Green Deal's objectives.

Theoretical Framework: Grounded in the European Green Deal and sustainability reporting paradigms, the study explores the integration of ESG (Environmental, Social, and Governance) standards and Sustainable Development Goals (SDGs) in shaping corporate practices, emphasizing risk management, financial access, corporate organization, and audit frameworks.
Method: A structured literature review is conducted, clustering themes into four categories: risk management, financial access, corporate organization, and audit processes. Both qualitative and quantitative approaches are employed to identify trends and best practices within ESG reporting and regulatory environments.

Results and Discussion: Findings reveal significant challenges in regulatory fragmentation, which hinder operational efficiency across jurisdictions. However, there is a positive trend toward the harmonization of ESG frameworks, enhancing financial stability and reducing agency costs. Integrating ESG criteria improves corporate transparency and market perceptions while fostering sustainability.

Research Implications: The evolving regulatory landscape presents challenges to the generalizability of findings. Nevertheless, the study offers actionable recommendations to promote regulatory convergence, supporting sustainable business practices and corporate accountability. Originality/Value: By adopting a novel clustering method, this paper provides an in-depth analysis of the interplay between European financial reporting standards and ESG frameworks. It contributes to understanding how harmonized regulations can facilitate sustainable corporate governance and transparency, offering insights for policymakers, managers, and stakeholders.
Empowering Creativity Of Disabled Students Through Sustainable Agropreneur Education at Ainul Yakin Islamic Boarding School in Yogyakarta to Support the SDGs
Authors: Nashihin Husna , Rachman Yenny Aulia , Fitrianto Ibnu , Suhartono  
Published: December 2024

Objective: The objective of this study is to examine the empowerment of creativity in disabled students through sustainable agropreneur-based education at Ainul Yakin Islamic Boarding School for Disabled Students in Yogyakarta. The aim is to explore the contribution of this program to the achievement of the Sustainable Development Goals (SDGs), particularly in education, decent work, and reducing inequality.

Theoretical Framework: This research is grounded in inclusive education and sustainable entrepreneurship theories. The integration of these two frameworks provides a foundation for understanding how agropreneurship can empower disabled students and enhance their economic independence while contributing to the broader SDGs.

Method: This qualitative case study used purposive sampling to select participants, including students, teachers, administrators, and community members. Data were collected through semi-structured interviews, non-participant observations, and document analysis of the school’s curriculum and student progress reports.

Results and Discussion: The study revealed that the agropreneur-based education significantly enhances the creativity and economic independence of disabled students. Through practical training in agriculture, students develop entrepreneurial skills that allow them to engage in sustainable business ventures. The challenges faced by students, such as limited resources and societal barriers, were also identified and discussed in light of inclusive education theories.

Research Implications: This research has practical implications for inclusive education, showing that agropreneur-based programs can be an effective model for empowering disabled students. It also contributes to policy development in education for special needs students.

Originality/Value: The study contributes to the literature by providing insights into how sustainable entrepreneurship education can support the empowerment of disabled students in Islamic boarding schools. This model is an innovative approach in Indonesia and highlights the role of inclusive education in achieving the SDGs.