bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Updated Review for the Diabetic Wound Healing Systems
Authors: Okur Mehmet E. , Bülbül Ece Ö. , Mutlu Gökçe , Eleftherıadou Kalliopi , Karantas Ioannis D. , Okur Neslihan Ü. , Siafaka Panoraia I. 
Published: September 2021

Background &; Objective:
Diabetes is a global health problem that has resulted in millions
of deaths; one of the most common diabetes complications is that wounds of diabetic patients
tend to heal more slowly or may not heal at all, resulting in undesirable outcomes. Diabetic
wounds, if become chronic and infected, could provoke lower extremities amputation, sepsis, and
even death. Hence, early detection, careful examination, debridement, cleaning, and prevention or
controlling the infection of diabetic wounds are important factors for the successful outcome of the
case. Over the years, various promising wound dressings incorporating antimicrobial molecules,
growth factors, and wound healing agents have been developed, targeting diabetic wounds.
Nonetheless, the choice of dressing is mainly based on the experience of each clinician.

Summary:
This review summarizes the main points of diabetes complications, diabetic wounds,
and infections. Further, an overview of the current drug delivery systems for topical wound delivery
of various active ingredients has been performed. This update could be helpful for scientists
and especially clinicians who desire to plan and work with new strategies for the healing of diabetic
wounds.
Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective
Authors: Sharma Tulika , Singh Joginder , Singh Bijender , Kataria Ramesh , Kumar Vinod 
Published: September 2021

:
Pyrazoles, an important and well known class of the azole family, have been found to show a large number of applications in various fields specially of medicinal chemistry. Among pyrazole derivatives, particularly, methyl substituted pyrazoles have been reported as the potent medicinal scaffolds that exhibit a wide spectrum of biological activities. The present review is an attempt to highlight the detailed synthetic approaches for methyl substituted pyrazoles along with in depth analysis of their respective medical significances till March2021. It is hoped that literature sum-up in the form of present review article would certainly be a great tool to assist the medicinal chemists for generating new leads possessing pyrazole nucleus with high efficacy and less microbial resistance.
Antibacterial, Antioxidant, and Angiotensin-I Converting Enzyme Inhibition
Effects of Margotia gummifera Extracts Rich in Phenolic Compounds
Authors: Bouchekrit Moufida , Laouer Hocine , Selim Çakmak Yavuz , Hajji Mohamed , Boutellaa Saber , Nasri Moncef , Akkal Salah 
Published: September 2021

Background:
Aromatic and medicinal plants have been used to substitute synthetic
drugs with natural bioactive products.

Objective:
The current investigation was conducted to evaluate phenol and flavonoid contents,
antibacterial, antioxidant, and anti-hypertensive potentials of three extracts of Margotia gummifera
aerial parts.

Methods:
The antibacterial effect was assessed using the wells agar diffusion method against 11
strains. The antioxidant effect was evaluated using different methods, 2, 2-diphenyl-1-picrylhydrazyl,
total antioxidant capacity, ferric reducing ability power, cupric reducing antioxidant capacity,
and β-carotene/linoleic acid bleaching assay. The anti-hypertensive activity was performed using
hippuryl-histidyl-leucine substrates.

Results:
The highest yield, i.e., 19.801%, was obtained by the hydro-methanolic extract. However,
ethyl acetate extract seemed to be rich in phenolic and flavonoid compounds compared to other extracts,
i.e., 822.14±69.10 mg GAE g-1 ext. and 117.28±1.80 mg RE g-1 ext., respectively. The high
free radical scavenging activity was mentioned in ethyl acetate extract with IC50 of 48.820±1.25
μg/ml. The same extract showed better antioxidant activity in all tested procedures. In antibacterial
activity, the hydro-methanolic extract exhibited moderate effect against all tested bacteria except
Salmonella enterica and Enterococcus faecalis which gave 18±2.0 and 16±1.0 mm of inhibition,
whereas it seemed to be inactive towards two Gram-negative bacteria. Concerning anti-hypertensive
activity, all extracts can inhibit the Angiotensin-I Converting Enzyme, but the potential effect
was given by hydro-methanolic and aqueous extracts, 97.75% and 96.65%, respectively.

Conclusion:
It can be stated that the bioactive compounds of Margotia gummifera extracts had different
biological activities, which confirm their therapeutic uses in traditional medicine.
The Role of miR-129-5p in Cancer: A Novel Therapeutic Target
Authors: Zeng Tiebing , Ling Hui , Xu Shan , Li Wei , Wu Jing , Lu Yuru , Xie Ming , Li Yanlan , Zou Juan 
Published: September 2021

Abstract:
miRNA-129-5p belongs to the microRNA-129 (miRNA-129) family. miRNA-129-5p is
expressed in many tissues and organs of the human body, and it regulates a wide range of biological
functions. The abnormal expression of miRNA-129-5p is related to the occurrence and development
of a variety of malignant tumors. miRNA-129-5p plays an important role in the tumorigenesis
process and functions by promoting or inhibiting tumors. However, the role of miRNA-129-5p
in cancer remains controversial. This article reviews the different biological functions of miRNA-
129-5p in cancer and provides ideas for research in this field to guide the development of targeted
therapies and drugs for malignant tumors.
mHealth for Anemia Reduction: Protocol for an Entertainment Education–Based Dual Intervention
Authors: Pant Ichhya , Rimal Rajiv , Yilma Hagere , Bingenheimer Jeffrey , Sedlander Erica , Behera Sibabrata 
Published: September 2021

Background
More than half of the women of reproductive age (aged 15-49 years) are anemic in India. The uptake of and adherence to iron folic acid (IFA) supplements remain low despite sustained efforts to increase their use. With India’s burgeoning digital environment, mobile phones offer a potential medium for increasing their uptake, especially when combined with interactive voice messages that deliver entertaining stories infused with norms-based educational messages.

Objective
This study aims to investigate whether a norms-based entertainment education mobile health intervention can increase self-efficacy for IFA adherence among women of reproductive age in Odisha, India.

Methods
Mobile reduction in anemia through normative innovations (mRANI) is a randomized 2-arm study that includes assessments before and after the intervention. All study participants will be recruited from the intervention arm of the parent reduction in anemia through normative innovations trial only. Although the usual practice is to randomize participants either to a treatment arm or a usual care control arm, we will assign the mRANI control group to another entertainment education–based treatment group that is designed to improve bystander intervention to reduce violence against women. Data collection for the mRANI study is embedded in the parent trial and will include baseline and end line assessments. The primary outcomes are self-efficacy for IFA adherence and violence against women–related bystander intervention. The inclusion criteria for the mRANI study are participation in the parent trial and phone ownership. Women (approximately n=400) who meet the mRANI inclusion criteria will be randomly assigned to the IFA arm or the bystander arm. Ordinary least squares regression with robust SEs will be conducted to assess between-group comparisons at the end line. A mediation analysis will be conducted to examine whether social norms and interactivity mediate the relationship between intervention exposure and primary outcomes in both arms. Real-time monitoring data will offer insights into intervention receptivity and audience engagement.

Results
Data collection for the mRANI study is integrated within the parent trial. Household surveys were conducted between February and March of 2021. Responses on the mRANI study’s primary and secondary outcomes were collected from 381 participants. The data analysis is expected to be completed by October 2021.

Conclusions
This study will provide evidence on whether a mobile health norms–based entertainment education intervention can increase self-efficacy for IFA adherence and violence against women–related bystander intervention.

International Registered Report Identifier (IRRID)
PRR1-10.2196/26252
Marketing Strategy for Chinese Market to Increase Room Occupancies at The Plataran Ubud Hotel
Authors: Muliadiasa I Ketut , Aprinica Ni Putu Isha 
Published: September 2021

Nowadays, Chinese tourists dominate Indonesian tourism, an increase in the number of Chinese tourists visiting Bali is quite significant every year. The marketing method that focuses on the Chinese market is still not maximized. This is evidenced by a decrease in the number of Chinese tourists visits. Even now the room occupancy rate targeted by Plataran Hotel Ubud has not yet reached the desired target. The urgency of this research is a degradation in the volume of sales of rooms at Hotel Plataran Ubud, which causes a derivation in the quantity of tourist visits which results in a decrease in employment for the community. Data collection techniques used were observation, interviews, document studies and questionnaires. The data analysis technique is using qualitative descriptive analysis, IFAS EFAS and SWOT analysis. The results of this study are to produce the right marketing strategy used in increasing the sales volume of hotel rooms at the Ubud Plataran Hotel.
El nexo migración-desarrollo en la Agenda 2030 para el desarrollo sostenible
Authors: Delkáder-Palacios Augusto 
Published: September 2021

What are the characteristics and what implications do the different frameworks of the migration-development nexus have in relation to the problem of migration-related conditionality? What framework of the migration-development nexus does the 2030 Agenda offer?
With this contribution we intend to reflect on the problem of migration-related conditionality. To do this, we analyze the political frameworks that support the different approaches to the so-called migration-development nexus. Our objective is to place this reflection in the 2030 Agenda for Sustainable Development to find out what vision of the migration-development nexus it formulates and, therefore, about the problem of migration-related conditionality.
The aid conditionality aid has been present since the origins of development policy. There are several types of conditionality, among which economic and political must be highlighted. As of September 11, the securitization of aid development was reinforced. Subsequently, the phenomenon of international migration became involved in that process. In this way the so-called migration-related conditionality arises. Firstly, we briefly expose the historical evolution of conditionality. Secondly, we explain the two theoretical-conceptual approaches to the migration-development nexus, which offer conflicting views: one approach states that migration positively impacts on development, while the other understands that the impact is negative. Finally, we offer a better understanding of the framing of migration and the conceptualization of the migration-development nexus carried out by 2030 Agenda. In this wat we can conclude whether this initiative seek to reduce or increase the migration-related conditionality.
Development of the methods for the class teacher effectiveness assessment
Authors: Nikolina Vera , Loshchilova Anna , Aksenov Sergey , Lebedeva Irina , Bazarnova Nadezhda 
Published: September 2021

The problem of developing a methodology for assessing the effectiveness of the class teacher’s educational activity and the possibility of its implementation in the context of an educational establishment has been getting more vital. The developed methodology for assessing the class teacher performance efficiency was tested on the basis of four educational establishments in Nizhny Novgorod, which are the clinical internship bases to train future teachers and class teachers at Minin University (Nizhny Novgorod), who were experts carrying out the examination of the methodology for assessing the performance efficiency according to the proposed indicators. The developed methodology for assessing the class teacher performance efficiency can be used in the practice of educational organizations to develop a system for assessing the encouragement of the class teacher performance, supervising his professional growth, developing individual trajectories of professional improvement, analytical conclusions, and expertise.
La enseñanza sexista de los deportes rugby y fútbol
Authors: Casajús Juan , Berdula Lorena 
Published: September 2021

Se propone indagar de forma preliminar las prácticas de la enseñanza en el rugby y fútbol examinando las categorías que emergen desde ellas y no a partir de lo que otros dicen que deberían ser, empleando nuestra propia voz al intentar explicarlas y describiendo lo que ocurre tal y como sucede. Este artículo pretende mostrar algunas líneas de propuestas didácticas para el aprendizaje del rugby y fútbol jugando de forma mixta- no binaria1 hasta una determinada edad (14 años en el rugby, 12 años en el fútbol), teniendo como consideración básica, la inclusión de sujetos diversos y de distintas condición física, bajo un contexto de actividades de enseñanza y aprendizaje basadas en las características que definen dichos deportes. Abordamos parcialmente concepciones de género que atraviesan el rugby y el fútbol, centrándonos en la voz de entrenadores y entrenadoras en ambos deportes. Es importante pensar la perspectiva de géneros y sexualidades, la interseccionalidad, los feminismos y transfeminismos para luego abordar la inclusión, los derechos humanos, la equidad, la igualdad de oportunidades y derechos en la enseñanza y acceso a la práctica del rugby y del fútbol, entre otros.
Modelling Frontier Mortality Using Bayesian Generalised Additive Models
Authors: Hilton Jason , Dodd Erengul , Forster Jonathan J. , Smith Peter W.F. 
Published: September 2021

Abstract
Mortality rates differ across countries and years, and the country with the lowest observed mortality has changed over time. However, the classic Science paper by Oeppen and Vaupel (2002) identified a persistent linear trend over time in maximum national life expectancy. In this article, we look to exploit similar regularities in age-specific mortality by considering for any given year a hypothetical mortality ‘frontier’, which we define as the lower limit of the force of mortality at each age across all countries. Change in this frontier reflects incremental advances across the wide range of social, institutional and scientific dimensions that influence mortality. We jointly estimate frontier mortality as well as mortality rates for individual countries. Generalised additive models are used to estimate a smooth set of baseline frontier mortality rates and mortality improvements, and country-level mortality is modelled as a set of smooth, positive deviations from this, forcing the mortality estimates for individual countries to lie above the frontier. This model is fitted to data for a selection of countries from the Human Mortality Database (2019). The efficacy of the model in forecasting over a ten-year horizon is compared to a similar model fitted to each country separately.
Spatio-Temporal Patterns in Portuguese Regional Fertility Rates: A Bayesian Approach for Spatial Clustering of Curves
Authors: Zhang Zhen , Bhattacharjee Arnab , Marques João , Maiti Tapabrata 
Published: September 2021

Abstract
It is important for demographic analyses and policy-making to obtain accurate models of spatial diffusion, so that policy experiments can reflect endogenous spatial spillovers appropriately. Likewise, it is important to obtain accurate estimates and forecasts of demographic variables such as age-specific fertility rates, by regions and over time, as well as the uncertainty associated with such estimation. Here, we consider Bayesian hierarchical models with separable spatio-temporal dependence structure that can be estimated by borrowing strength from neighbouring regions and all years. Further, we do not consider the adjacency structure as a given, but rather as an object of inference. For this purpose, we use the local similarity of temporal patterns by developing a spatial clustering model based on Bayesian nonparametric smoothing techniques. The Bayesian inference provides the uncertainty associated with the clustering configurations that is typically lacking in classical analyses of large data sets in which a unique clustering representation can be insufficient. The proposed model is applied to 16-year data on age-specific fertility rates observed over 28 regions in Portugal, and provides statistical inference on the number of clusters, and local scaling and shrinkage levels. The corresponding central clustering configuration is able to capture spatial diffusion that has key demographic interpretations. Importantly, the exercise aids identification of peripheral regions with poor demographic prospects and development of regional policy for such places.
Optimal Sampling for the Population Coverage Survey of the New Italian Register Based Census
Authors: Righi Paolo , Falorsi Piero Demetrio , Daddi Stefano , Fiorello Epifania , Massoli Pierpaolo , Terribili Marco Dionisio 
Published: September 2021

Abstract
For the first time in 2018 the Italian Institute of Statistics (Istat) implemented the annual Permanent Population Census which relies on the Population Base Register (PBR) and the Population Coverage Survey (PCS). This article provides a general overview of the PCS sampling design, which makes use of the PBR to correct population counts with the extended dual system estimator (Nirel and Glickman 2009). The sample allocation, proven optimal under a set of precision constraints, is based on preliminary estimates of individual probabilities of over-coverage and under-coverage. It defines the expected sample size in terms of individuals, and it oversamples the sub-populations subject to the risk of under/over coverage. Finally, the article introduces a sample selection method, which to the greatest extent possible satisfies the planned allocation of persons in terms of socio-demographic characteristics. Under acceptable assumptions, the article also shows that the sampling strategy enhances the precision of the estimates.
Latent Class Analysis for Estimating an Unknown Population Size – with Application to Censuses
Authors: Baffour Bernard , Brown James J. , Smith Peter W.F. 
Published: September 2021

Abstract
Estimation of the unknown population size using capture-recapture techniques relies on the key assumption that the capture probabilities are homogeneous across individuals in the population. This is usually accomplished via post-stratification by some key covariates believed to influence individual catchability. Another issue that arises in population estimation from data collected from multiple sources is list dependence, where an individual’s catchability on one list is related to that of another list. The earlier models for population estimation heavily relied upon list independence. However, there are methods available that can adjust the population estimates to account for dependence among lists. In this article, we propose the use of latent class analysis through log-linear modelling to estimate the population size in the presence of both heterogeneity and list dependence. The proposed approach is illustrated using data from the 1988 US census dress rehearsal.
Enhancing active living and physical exercise through environmentally friendly policies in urban areas
Authors: Kouthouris Charilaos , Zafeiroudi Aglaia , Georgomanos Sotirios , Kontogianni Evangelia 
Published: September 2021

Abstract
Active living offers a substantial contribution to the mental and physical health of individuals, as well as to community wellbeing and social cohesion. Outdoor and green environments offer additional benefits and determine people’s involvement in physical exercise. Environmental policies put in place by local governments affect citizens’ adoption of active living and physical exercise. The aim of the present study was to investigate the relationship between citizens’ levels of exercise participation in urban open spaces and the provision of exercise-friendly policies by the local authorities. Three hundred and seventy citizens participated in the present study who took part in walking, bicycling, or jogging/ running during their leisure time in urban open spaces and outdoors. Research participants completed the Godin Leisure-Time Exercise Questionnaire (GLTEQ; Shephard, 1997) and Environmentally Friendly Exercise Policy Questionnaire (Kontogianni, 2015), which consisted of three scales: “policy to enhance exercise,” “environmentally friendly exercise facilities,” and “intention to change personal habits.” Participants were divided into three different subgroups according to their time exercise scores: high, middle, and low. The results showed the statistically significant differences between time exercise scores and environmentally friendly exercise policy scales. Citizens with higher exercise time participation expressed significantly higher levels on the environmentally friendly exercise policy scales. Citizens’ physical exercise time in urban open spaces and outdoors seemed to affect the creation of corresponding preferences, beliefs, and intentions towards environmentally friendly policies. City leaders, essential decision-makers, and stakeholders are expected to provide an enabling environment, legitimacy, and leadership that fosters the development and implementation of policies that support physical activity and green active living within urban spaces.
The UAE Tour, cycling stars, and Twitter: Tweeting as part of promoting the host country
Authors: Zákravský Jiří 
Published: September 2021

Abstract
Using the example of the 2019 inaugural UAE Tour, this study demonstrates how cycling stars indirectly promote countries hosting globally watched sporting events through their Twitter accounts. This study presents a qualitative and quantitative content analysis of the Twitter activity of selected cycling stars. However, this promotion is only a secondary result of their activity on social media; professional athletes use their Twitter accounts as a platform for self-presentation and to show their daily lives to fans. If the athletes are active on social media, it is almost impossible for them to avoid speaking about the host countries, indirectly evaluate them, and provide information about them to their followers. While sports celebrities’ social media profiles are a limited space for the promotion of host countries, they can also help improve the image of the countries and present them in a positive light. Of course, political leaders use countless public or sports diplomacy tools to promote their countries abroad, and online platforms are not necessarily a key element in the promotion of their international image.