bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of rhBMP-2 for adult spinal deformity surgery: patterns of usage and changes over the past decade
Authors: Bannwarth Mathieu , Smith Justin S. , Bess Shay , Klineberg Eric O. , Ames Christopher P. , Mundis Gregory M. , Kim Han Jo , Lafage Renaud , Gupta Munish C. , Burton Douglas C. , Shaffrey Christopher I. , Schwab Frank J. , Lafage Virginie , _ _ 
Published: June 2021

OBJECTIVE
Recombinant human bone morphogenetic protein–2 (rhBMP-2) has been shown to increase fusion rates; however, cost, limited FDA approval, and possible complications impact its use. Decisions regarding rhBMP-2 use and changes over time have not been well defined. In this study, the authors aimed to assess changes in rhBMP-2 use for adult spinal deformity (ASD) surgery over the past decade.

METHODS
A retrospective review of the International Spine Study Group prospective multicenter database was performed to identify ASD patients treated surgically from 2008 to 2018. For assessment of rhBMP-2 use over time, 3 periods were created: 2008–2011, 2012–2015, and 2016–2018.

RESULTS
Of the patients identified, 1180 met inclusion criteria, with a mean age 60 years and 30% of patients requiring revision surgery; rhBMP-2 was used in 73.9% of patients overall. The mean rhBMP-2 dose per patient was 23.6 mg. Patients receiving rhBMP-2 were older (61 vs 58 years, p < 0.001) and had more comorbidities (Charlson Comorbidity Index 1.9 vs 1.4, p < 0.001), a higher rate of the Scoliosis Research Society–Schwab pelvic tilt modifier (> 0; 68% vs 62%, p = 0.026), a greater deformity correction (change in pelvic incidence minus lumbar lordosis 15° vs 12°, p = 0.01), and more levels fused (8.9 vs 7.9, p = 0.003). Over the 3 time periods, the overall rate of rhBMP-2 use increased and then stabilized (62.5% vs 79% vs 77%). Stratified analysis showed that after an overall increase in rhBMP-2 use, only patients who were younger than 50 years, those who were smokers, those who received a three-column osteotomy (3CO), and patients who underwent revision sustained an increased rate of rhBMP-2 use between the later two periods. No similar increases were noted for older patients, nonsmokers, primary surgery patients, and patients without a 3CO. The total rhBMP-2 dose decreased over time (26.6 mg vs 24.8 mg vs 20.7 mg, p < 0.001). After matching patients by preoperative alignment, 215 patients were included, and a significantly lower rate of complications leading to revision surgery was observed within the 2012–2015 period compared with the 2008–2011 (21.4% vs 13.0%, p = 0.029) period, while rhBMP-2 was increasingly used (80.5% vs 66.0%, p = 0.001). There was a trend toward a lower rate of pseudarthrosis for patients in the 2012–2015 period, but this difference did not reach statistical significance (7% vs 4.2%, p = 0.283).

CONCLUSIONS
The authors found that rhBMP-2 was used in the majority of ASD patients and was more commonly used in those with greater deformity correction. Additionally, over the last 10 years, rhBMP-2 was increasingly used for ASD patients, but the dose has decreased.
Safety and efficacy of low-dose rhBMP-2 use for anterior cervical fusion
Authors: Mendenhall Stephen K. , Priddy Blake H. , Mobasser Jean-Pierre , Potts Eric A. 
Published: June 2021

OBJECTIVE
The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) in routine anterior cervical fusion (ACF) is controversial. Early reports described high complication rates. A variety of dosing regimens ranging from 0.6 to 2.1 mg per level fused have been reported. The authors hypothesized that the high amounts of rhBMP-2 used in these studies led to the high complication rates observed; therefore, they set out to evaluate the safety and efficacy of low-dose rhBMP-2 for use in ACFs.

METHODS
Patient inclusion criteria were 1) age 18 to 70 years; 2) initial stand-alone ACF construct; 3) fusion augmentation with rhBMP-2; and 4) at least 1 year of radiographic follow-up. A successful fusion was defined by either 1) lateral flexion-extension radiographs with less than 1 mm of movement across the fused spinous processes, or 2) bone bridging at least half of the fusion area originally achieved by surgery on fine-cut CT. Patient demographics, perioperative data, and postoperative complications were recorded.

RESULTS
A total of 198 patients met the inclusion criteria and were included for analysis. Sixty-two patients (31%) were smokers. The median number of levels fused was 2 (IQR 1.25). The mean dose of rhBMP-2 was 0.50 ± 0.09 mg per level. Twenty-two (11%) patients experienced dysphagia. Eleven (6%) patients experienced cervical swelling. Two (1%) patients returned to the operating room (OR) for postoperative hematoma. One (0.5%) patient returned to the OR for seroma. Two (1%) patients experienced pseudarthrosis requiring a posterior fusion. Three (2%) patients experienced a new postoperative neurological deficit that had recovered by last the follow-up. Overall, 190 (96%) patients experienced solid arthrodesis over an average of 15 months of follow-up. There was no difference in fusion rates between patients who were either smokers or nonsmokers (p = 0.7073).

CONCLUSIONS
The use of low-dose rhBMP-2 safely and effectively augmented anterior cervical arthrodesis. The low-dose protocol assessed in this study appeared to significantly reduce complications associated with rhBMP-2 use in ACF compared with the literature. The authors have determined that using low-dose rhBMP-2 in patients who are smokers, those with multilevel ACFs, or others at high risk of developing pseudarthrosis is recommended.
The effect of IL-1β on MRP2 expression and tamoxifen toxicity in MCF-7 breast cancer cells
Authors: Valinezhad Sani Fatemeh , Alamolhodaei Nafiseh Sadat , Rashidpoor Hatam , Gharaee Melika Ehtesham , Behravan Javad , Mosaffa Fatemeh 
Published: June 2021

BACKGROUND: Chronic inflammation is considered to be a risk factor for carcinogenesis, tumor development and metastasis by providing tumor-related factors. OBJECTIVES: We aimed to evaluate the effect of cytokine interleukin-1β (IL-1β) as a key mediator of inflammation on multidrug resistance associated protein 2 (MRP2) expression and tamoxifen toxicity in estrogen receptor positive (ER+) MCF-7 breast cancer cells. METHODS: The effects of IL-1β on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1β and/or 17β-estradiol (E2) were measured by MTT assay. Furthermore, the effects of IL-1β and/or E2 on the mRNA expression and protein levels of MRP2 and NF-κB (p65) in breast cancer cells were evaluated by QRT-PCR and Western blot analysis, respectively. RESULTS: Treatment of breast cancer cells with IL-1β+ E2 decreased the sensitivity to 4-OH tamoxifen compared to both E2-treated and untreated cells. The mRNA expression levels of MRP2 and NF-κB (p65) were significantly increased following treatment with IL-1β+ E2, compared to control. In addition, breast cancer cells treatment with IL-1β+ E2 increased protein expression of MRP2 and it had no significant effect on NF-κB/p65 protein expression in these cells. CONCLUSION: Increased expression of mRNA and protein level of MRP2 following 20-day treatment of MCF-7 cells with IL-1β + E2 might be a possible elucidation for the increased tamoxifen resistance which was observed in these cells. More researches are essential to clarify the molecular mechanisms of inflammation on drug-resistance in the tumor environment in order to reducing or eliminating chemotherapy resistance and developing more effective treatment strategies.
Association between molecular subtype of local advanced breast cancer with Ca 15-3 level
Authors: Ruswendro Dony , Syamsu Salman Ardi , Thabry Rudy , Seweng Arifin , Usman Andi Nilawati 
Published: June 2021

BACKGROUND: Neoplasm is an abnormal mass of tissue that grows excessively and not coordinated with normal tissue growth and continues to do so even though the stimulation that triggered the change has stopped. Breast cancer can be known by using tumor marker, which has been used is mucin-like glycoprotein Carcinoma Antigen (CA 15-3) which is a tumor marker that is specific to breast cancer. METHOD: This study is a cross-sectional study to determine the association between molecular subtypes of locally advanced breast cancer with CA 15-3 level at Abdul Wahab Sjahranie Samarinda Hospital. The population in this study were all breast cancer patients that were confirmed by histopathological examination. RESULTS: A total of 75 patients were included for this study, 29 patients (38.7%) known as Overexpression HER2, 18 patients (24.0%) were Luminal B with HER2 (+), 11 patients (14.7%) were Luminal B with HER2 (−), 11 patients (14.7%) were Basal-like/TNBC, and 6 patients (8,0%) were Luminal A. From the ANOVA test, the value of p = 0.045 (p < 0.05) means there was an association between Ca 15-3 level and molecular subtypes in patients with locally advanced breast cancer at the Abdul Wahab Sjahranie Hospital in Samarinda 2017. In this study Ca 15-3 levels were obtained on average for Luminal A 16.98 U/mL, Luminal B with HER2 (−) 42.41 U/mL, Luminal B with HER2 (+) 73.75 U/mL, Overexpression HER2 47.73 U/mL, and Basal Like /TNBC 63.50 U/mL. CONCLUSION: Statistically, it was found that there was an association between Ca 15-3 levels and molecular subtypes in patients with locally advanced breast cancer at the Abdul Wahab Sjahranie Hospital in Samarinda 2017.
Relationship between explosive strength characteristics with change of direction speed in junior and cadet karate athletes
Authors: Ojeda-Aravena Alex , Herrera-Valenzuela Tomás , Valdés-Badilla Pablo , Azócar-Gallardo Jairo , Campos-Uribe Victor , García-García José Manuel 
Published: June 2021

BACKGROUND: Explosive strength and change of direction speed (CODS) are relevant physical abilities in karate. OBJECTIVE: To examine the relationship between the characteristics of explosive strength and the 5-m linear sprint (5M) with CODS performance and ii) to examine the influential characteristics of explosive strength on CODS performance. METHODS: Eighteen cadet and junior karate athletes, eight females and ten males were evaluated. The physical abilities assessments included: squat jump (SJ), countermovement jump (CMJ), 5M and CODS. Also, pre-stretch percentage increase (PSA), eccentric utilization index (EUR) reactive strength index (RSI) were calculated. RESULTS: Superior performance ([Formula: see text] 0.05) was documented in SJ, CMJ and CODS in male vs. female. Also, significant correlations between CODS with SJ and CMJ ([Formula: see text]0.70 to [Formula: see text]0.80; [Formula: see text]0.51 to [Formula: see text]0.73; [Formula: see text] 0.05, respectively) and correlations ([Formula: see text]0.14 to [Formula: see text]0.22; [Formula: see text] 0.01 to 0.04; [Formula: see text] 0.05) between CODS with RSI, EUR and PSA. Multiple regression model documented that only SJ significantly influenced CODS performance in male ([Formula: see text] 60%; [Formula: see text] 0.009) and female ([Formula: see text] 71%; [Formula: see text] 0.001). CONCLUSION: CODS correlate with SJ and CMJ. In particular, SJ influence CODS independently of gender.
Strength normalized to muscle volume rather than body weight is more accurate for assessing knee strength following anterior cruciate ligament reconstruction
Authors: Ohji Shunsuke , Aizawa Junya , Hirohata Kenji , Ohmi Takehiro , Mitomo Sho , Koga Hideyuki , Yagishita Kazuyoshi 
Published: June 2021

BACKGROUND: Knee strength weakness is a major problem frequently observed in patients during postoperative rehabilitation following anterior cruciate ligament reconstruction (ACLR). OBJECTIVE: To investigate whether knee strength normalized to muscle volume could better detect side-to-side differences than that normalized to body weight following ACLR. METHOD: This study included 17 patients who had undergone primary ACLR (11.6 [Formula: see text] 2.3 months). Body weight and total muscle volume were measured using a bioelectrical impedance analysis composition scale. Isokinetic knee extension and flexion moment were measured at 60[Formula: see text]/s and 180[Formula: see text]/s, respectively. Bivariate correlation analysis was used to examine correlations between body composition and knee strength. Differences in knee strength between the operated and unoperated legs were analyzed using a paired [Formula: see text]-test, which calculated the effect size. RESULTS: There was a significant correlation between knee strength and body weight ([Formula: see text] 0.53–0.67); however, a stronger correlation was observed between knee strength and total muscle volume ([Formula: see text] 0.80–0.87). The effect size was larger for knee strength expressed as % total muscle volume than for knee strength expressed as % body weight. CONCLUSION: Strength expressed as % total muscle volume may be more accurate than that expressed as % body weight for detecting side-to-side differences in knee strength following ACLR.
Internet of things-based smart wearable system to monitor sports person health
Authors: Li Fen , Martínez Oscar Sanjuán , Aiswarya R.S. 
Published: June 2021

BACKGROUND: The modern Internet of Things (IoT) makes small devices that can sense, process, interact, connect devices, and other sensors ready to understand the environment. IoT technologies and intelligent health apps have multiplied. The main challenges in the sports environment are playing without injuries and healthily. OBJECTIVE: In this paper the Internet of Things-based Smart Wearable System (IoT-SWS) is introduced for monitoring sports person activity to improve sports person health and performance in a healthy way. METHOD: Wearable systems are commonly used to capture individual sports details on a real-time basis. Collecting data from wearable devices and IoT technologies can help organizations learn how to optimize in-game strategies, identify opponents’ vulnerabilities, and make smarter draft choices and trading decisions for a sportsperson. RESULTS: The experimental result shows that IoT-SWS achieve the highest accuracy of 98.22% and efficient in predicting the sports person’s health to improve sports person performance reliably.
Contemporary art in theory and practice
Authors: Afonina Olena 
Published: June 2021

The purpose of the article is to summarize information about the study of artistic practices of contemporary art in the aspect of psychological concepts of study. The methodology of the work is based on the use of general scientific research methods. A comparative analysis is applied to conceptualize the provisions of psychology for the analysis of works of contemporary art. The scientific novelty of the work lies in the introduction of conceptual provisions from psychoanalytic research to the analysis of works of musical, visual, choreographic art of the late XX - XXI centuries. Conclusions. The concepts of psychologists (K. G. Jung, R. Atkinson and R. Shiffrin, D. Anderson and G. Bauer, L. Brooks, A. Paivio, J. Santa, P. Vollen, S. Lauri and M. Weber) reveal the mechanisms of perception of modern art. Characterization of mnemonic processes of memory with such operations: orientation in the semantic structure of the material, dismemberment and grouping of semantic elements, establishing links between the structural units of the text, recoding verbal information into figurative, consolidating the material, memorization in general, and in parts occur in creative processes and processes of perception of the majority cultural codes. The use of concepts (quotation, allusion, reminiscence, contamination) to the analysis of works of contemporary art is confirmed by the results of research by psychologists on the perception of cited visual, auditory, verbal information, which evokes allusions or reminiscences to previously known material, but now with new connotations on the example of works by Yu. Gomelskaya, A. Zhivotkov, A. Kozarenko, R. Poklitaru, A. Rodin, E. Stankovich.
Anthropomorphic symbolic images in the Ukrainian folk dancing culture
Authors: Kinder Karyna 
Published: June 2021

The purpose of the article is to define the semantics of the actional forms and compositional structures of circle dances and dancing pantomimes featuring the anthropomorphic images which are characteristic of the traditional annual calendar, rites of passage, and family routine ceremonialism laying the original background of the Ukrainian artwork. The methodology rests on the grounds of the complex approach and the application of analytical (art-critical, philosophical, cultural approaches to the field of study), historical (the Ukrainian choreography genesis study), cultural (examining functions performed by folk dancing culture in the spiritual life of the Ukrainian ethnos) and semiotic (analysis of dance signs structure and dancing symbols semantics) methods. Scientific novelty: the author has conducted a complex art critical research of the anthropomorphic images that became symbols in the Ukrainian national tradition with the determination of their in-depth semantic meaning and functional role in the national dancing art. Conclusions. Within the imagery richness of the Ukrainian folk choreography, there are a lot of sign-symbols, character-symbols represented in dance space patterns, and figures reproduced by performers’ plastic movements. The study of the structural-verbal and symbolic features of these choreographic patterns gives reasons to claim about their undoubted archaic roots in a play mode reflecting the unique variant of the transitional ritual (passage rite) related to an individual’s life, his status, and the external world.
Aniko Rekhviashvili's creativity in the context of the development of the choreographic art of Ukraine in the late XX - early XXI centuries
Authors: Vyshotravka Liudmyla 
Published: June 2021

The purpose of the article was a comprehensive art criticism analysis of the creative heritage of the choreographer A. Rekhviashvili, during which the main stages of her stage biography were considered, the characteristic features of the staging style were determined. The methodology of the work includes the use of the following cultural research methods: general historical, comparative historical, analytical, biographical, etc. The scientific novelty of the publication lies in the fact that for the first time it comprehensively analyzes the stage achievements of the choreographer A. Rekhviashvili, establishes the influence of her work on the development of national ballet art late XX - early XXI centuries. Conclusions. Choreographer A. Rekhviashvili can without a doubt be considered one of the most progressive Ukrainian choreographers of our era since the stage works created by her: dance miniatures, one-act performances, and multi-act ballet canvases - "Vienna Waltz" (2001), "Daniela" (2006), “Lady with Camellias” (2014), “Daphnis and Chloe” (2015), “The Snow Queen” (2016), “Julius Caesar” (2018), etc. - highly appreciated by modern ballet experts and recognized as the brightest examples of Russian choreographic art of the border XX – XXI centuries, in which academic traditions and new forms of plastic expressiveness were harmoniously combined.
A Primer on Exporting to Panama
Authors: Storz Christina D. , Taylor Timothy G. , Fairchild Gary F. 
Published: June 2021

Every year the U.S. Department of State publishes extensive Country Commercial Guides for a large number of countries. These guides provide a great deal of information useful to individuals interested in developing export markets either through direct exports or through direct foreign investment. This paper provides an abridged version of the Country Commercial Guide for Panama as well as supplemental information of direct relevance to agribusiness firms. It is hoped that the information contained in this report provides a useful starting point for individuals interested in exploring export or investment opportunities in Panama. This is EDIS document FE519, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL. Published February 2005.
A Primer on Exporting to Suriname
Authors: Storz Christina D. , Taylor Timothy G. , Fairchild Gary F. 
Published: June 2021

Every year the U.S. Department of State publishes extensive Country Commercial Guides for a large number of countries. These guides provide a great deal of information useful to individuals interested in developing export markets either through direct exports or through direct foreign investment. This paper provides an abridged version of the Country Commercial Guide for Suriname as well as supplemental information of direct relevance to agribusiness firms. It is hoped that the information contained in this report provides a useful starting point for individuals interested in exploring export or investment opportunities in Suriname. This is EDIS document FE522, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL. Published February 2005.
Entendiendo el Acuerdo de Medidas Sanitarias y Fitosanitarias (MSF) de la Organización Mundial del Comercio (OMC)
Authors: Evans Edward A. 
Published: June 2021

Esta publicación es parte de una serie que trata de políticas de comercio. La liberalización del comercio internacional y la globalización general de la economía mundial en las últimas dos décadas ha significado que agricultores, comerciantes y grupos en la comunidad se familiarizen con políticas de comercio y su terminología para poder beneficiarse de la globalización y para minimizar costos. Consequentemente, el objetivo de esta serie de publicaciones es ayudar a la gente a entender los tópicos del comercio mundial que benefician o dan problemas. Esta publicación, la primera de una serie, discute el término "Acuerdo de MSF de la OMC" (Acuerdo de Medidas Sanitarias y Fitosanitarias de la Organización Mundial de Comercio). Este documento, FE530, es uno de una serie de publicaciones del Departamento de Food and Resource Economics, Servicio de Extensión Cooperativa de la Florida, Instituto de Alimentos y Ciencias Agrícolas, Universidad de la Florida. (UF/IUFAS). Fecha de primera publicación: February 7, 2005.
Effect of Apogee and Ponnax on Stolon Production and Yield of Florida-Grown Strawberry.
Authors: Duval John R. , Golden Elizabeth 
Published: June 2021

Stolon production by strawberry plants in Florida fruiting fields is highly undesirable. Stolons (runners) act as a sink for photosynthates and nutrients, reducing the amount of resources available for fruit production in an annual hill production system. The presence of stolons makes it more difficult for pickers to find berries among the excess vegetation. Hence, manual labor must be used to remove runners in the fruiting field at a cost of $40 to $60 per acre. If a low-cost chemical means could be found to reduce or eliminate runner production in the fruiting field, producers would benefit greatly. This document is HS989, one of a series of the Horticultural Sciences Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Original publication date July 30, 2004.