bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer Acceptance of Brown and White Rice Varieties
Authors: Gondal Tanweer Aslam , Keast Russell SJ , Shellie Robert A , Jadhav Snehal R , Gamlath Shirani , Mohebbi Mohammadreza , Liem Djin Gie 
Published: May 2021

Abstract

Rice is consumed as a staple food by more than half of the world’s population. Due to a higher fibre and micronutrient content, brown rice is more nutritious than white rice, but the consumption of brown rice is significantly lower than that of white rice, primarily due to sensory attributes. Therefore, the present research aimed to identify the sensory attributes which drive liking of Australian-grown brown and white rice varieties. Participants (n = 139) tasted and scored (9-point hedonic scale) their liking (i.e., overall liking, aroma, colour and texture) of brown and white rice types of Jasmine (Kyeema), Low GI (Doongara) and Medium grain rice (Amaroo). In addition, participants scored, aroma, colour, hardness, fluffiness, stickiness and chewiness, on Just About Right Scales. A within-subjects crossover design with randomised order (William’s Latin Square design) was used with six repeated samples for liking and Just About Right scales. Penalty analyses were applied to determine the relative influence of perception of sensory attributes on consumer liking of the rice varieties. Across all varieties, white rice was liked more than brown rice due to texture and colour, and Jasmine rice was preferred over Low GI and Medium Grain. Rice texture (hardness and chewiness) was the most important sensory attribute among all rice varieties and aroma was important for driving of liking between white rice varieties.
WITHDRAWN: Pani:Cuo Nanocomposite as Electrolyte Material for Electrochemical Supercapacitor Application
Authors: S Ashokan , V Ponnuswamy , P Jayamurugan 
Published: May 2021

Abstract
PANI:CuO nanocomposite have been prepared by systematically adding different amounts of ammonium per sulfate as an oxidizing agent. Surface morphology shows the uniform distribution of CuO nanopowders in PANI matrix. TEM study gives the grain size of the as prepare PANI:CuO nanocomposite. FT-IR and UV-Vis studies confirm PANI is present and show the incorporation of CuO in polymer matrix. The data obtained by FT-IR measurements show the possible incorporation of CuO in PANI, rate of most interaction and the conductivity decrease due to the increase of APS content in the formed hybrid composites. A capacitance of polymeric materials is remarkably enhanced due to the synergistic effect between CuO and PANI. Moreover, the composite demonstrates good capacitive and charge/discharge properties.
Development of a Highly Efficient Technology for Accelerated Bread Production
Authors: Tursunbayeva Sholpan Arystanbekovna , Iztayev Auyelbek Iztayevich , Mynbayeva Aizhan Berdaliyevna , Alimardanova Mariam Kalabaevna , Iztayev Baurzhan Auyelbekovich , Yakiyayeva Madina Asatullaevna 
Published: May 2021

Abstract
The bakery market is one of the most capacious in Kazakhstan. Manufacturers of bread products are in dire need of the introduction of intensive technologies for improving product quality and safety. This article presents the results of research to develop technology for accelerated production of bread with ion-ozone cavitation treatment. The influence of various modes of exposure to ion-ozone cavitation has been investigated. After baking, bread samples were examined for organoleptic, physicochemical, rheological and microbiological indicators. The optimal method is treatment with ion-ozone at a concentration of 0.0025 units/mg, at a pressure of 1.0 atm for 1 min. As a result, it was proved that this mode accelerates the process of obtaining dough and shortens the fermentation time, and baking bread increases the qualitative and quantitative indicators according to the control method. The results showed that the ion-ozone technology reduces the length of the process of making dough and bread by three times compared to traditional technologies. The developed products with existing analogues in the Kazakhstan market will differ due to their high taste and consumer properties, product safety, long shelf life and low cost.
Association Between Phosphate and Long-term Outcome in CAD Patients Underwent Coronary Intervention
Authors: Tsai Tsung-Ying , Hsu Pai-Feng , Wu Cheng-Hsueh , Yang Ya-Ling , Chen Su-Chan , Huang Shao-Sung , Chan Wan Leong , Lin Shing-Jong , Chen Jaw-Wen , Pan Ju-Pin , Charng Min-Ji , Chen Ying-Hwa , Wu Tao-Cheng , Lu Tse-Min , Huang Po-Hsun , Cheng Hao-Min , Huang Chin-Chou , Sung Shih-Hsien , Lin Yenn-Jiang , Leu Hsin-Bang 
Published: May 2021

Abstract
IntroductionPhosphate has been linked to higher cardiovascular (CV) risk. However, whether phosphate is associated with poor outcomes for patients with coronary artery disease (CAD) after percutaneous coronary interventions (PCIs) remained undetermined. Methods 2,894 CAD patients (2,220 male, aged 71.6 ± 12.2), who received PCI at TVGH from 2006 to 2015, with phosphate measurement, were enrolled. The primary outcome was the composite of major adverse CV events [MACE, comprising of CV death, nonfatal MI, and nonfatal stroke] and heart failure hospitalization(HHF). The key secondary outcome was MACE. ResultsThere was a J-curve association between phosphate and CV events after adjusted for comorbidities and renal function. Phosphate around 3.2 ± 0.1mg/dL was associated with the lowest CV risk. In Cox analysis, each 1 mg/dL increases in phosphate was associated with a higher risk of MACE+HHF (HR:1.12, 95% CI:1.05-1.21): CV death (HR: 1.37,95% CI: 1.22-1.55) and HHF (HR: 1.12, 95% CI: 1.02-1.23). Subgroup analyses showed more prominent association between phosphate and MACE+HHF in male, age > 65, bare-metal stents (BMSs), LVEF< 50%, eGFR <60, LDL >70 mg/dL, and emergent PCI.ConclusionPhosphate has a J-curve association with the risk of CV events in CAD patients undergoing PCI that was independent of comorbidities and renal function.
Preparation of Single-phase High Entropy Carbides by a Modified Citric Acid Complexing Method
Authors: Liu Hu-Lin , DANG Feng-Zhen , NI De-Wei , LIU Chang-Qing , XUE Yun-Long , WU Yuan-Ting 
Published: May 2021

Abstract
We developed a new method to synthesize single-phase transition metal carbide powders by combining citric acid complexing method and ball-milling dispersion. High-entropy carbides (Zr0.25Ti0.25Ta0.25Nb0.25)C (4TmC), (Zr0.2Ti0.2Ta0.2Nb0.2Hf0.2)C (5TmC-H) and (Zr0.2Ti0.2Ta0.2Nb0.2Mo0.2)C (5TmC-M) were successfully fabricated by this method using low-cost raw materials. The element and phase composition and microstructures of the obtained carbide powders were investigated. The relationships of synthesis process and temperature with chemical composition were also discussed. (Zr0.25Ti0.25Ta0.25Nb0.25)C can be obtained by a one-step process at 1550 °C, while (Zr0.2Ti0.2Ta0.2Nb0.2Hf0.2)C and (Zr0.2Ti0.2Ta0.2Nb0.2Mo0.2)C are fabricated by a two-step process of carbothermal reduction followed by solid solution at the temperatures not lower than 1850 °C and 1650 °C. The higher synthesis temperatures of the five-component carbides are attributed to the obvious sluggish diffusion effect induced by the larger lattice distortions. The particle sizes of (Zr0.25Ti0.25Ta0.25Nb0.25)C, (Zr0.2Ti0.2Ta0.2Nb0.2Hf0.2)C and (Zr0.2Ti0.2Ta0.2Nb0.2Mo0.2)C powders are 118.2±26.1 nm (at 1550 °C), 284.8±73.7 nm (at 1850 °C) and 65.5±13.9 nm (at 1750 °C), respectively.
SPOCK2 Expression Correlates with Non-Small Cell Lung Cancer Proliferation, Invasion, and Tumorigenesis
Authors: Xu Yitong , Liang Lijie , Zhu Chaonan , Wang Chenglong , Jiang Jun , Zhang Yao , Jiang Xizi , Su Hongbo , Ren Hongjiu , Qiu Xueshan 
Published: May 2021

Abstract
Purpose: Lung cancer is one of the leading causes of death worldwide. Sparc (osteonectin), cwcv, and Kazal-like domains proteoglycan 2 (SPOCK2) play important roles in the development and progression of various types of human cancers. However, the role of SPOCK2 in non-small-cell lung cancer (NSCLC) is unclear. Hence, we aimed to elucidate the role of SPOCK2 in NSCLC. Methods: Real-time PCR and immunohistochemistry were used to study the relationship between SPOCK2 expression and the clinicopathology of NSCLC. SPOCK2 expression was modulated using siRNA (knockdown) or pcmv6-myc-DDK-SPOCK2 (overexpression). The invasion and migration abilities of NSCLC cells were assessed using a Transwell chamber assay, and cell proliferation was studied using the MTT and colony formation assays. Furthermore, axilla and tail vein inoculation using nude mice helped elucidate the function of SPOCK2 in vivo. The expression of related proteins was analyzed using western blotting. SPOCK2 methylation was detected using real-time PCR following the treatment of cells with decitabine. Results: The mRNA and protein levels of SPOCK2 were lower in NSCLC tissues than in adjacent normal lung tissues. SPOCK2 overexpression inhibited cell proliferation, migration, and invasion in A549, H1299 cells, and nude mice. Notch and Erk signaling pathways were inhibited by SPOCK2, whereas the Hippo pathway was activated. SPOCK2 was methylated in NSCLC cell lines. SPOCK2 expression was negatively correlated with NSCLC progression. Conclusion: Taken together, our findings indicate that SPOCK2 methylation may result in its low expression, and the levels of SPOCK2 methylation may be associated with poor prognosis in NSCLC.
Candida and the Gram-Positive Trio: Testing the Vibe in the Icu Patient Microbiome Using Structural Equation Modelling of Literature Derived Data.
Authors: Hurley James 
Published: May 2021

Abstract
BackgroundWhether Candida interacts with Gram-positive bacteria to enhance their invasive potential from the microbiome of ICU patients remains unclear. Several effective interventions to prevent ICU acquired infection would be expected to variably impact Candida colonization.MethodsFour candidate generalized structural equation models (GSEM), using Staphylococcus aureus, coagulase negative Staphylococci (CNS) and Enterococci colonization as latent variables, were confronted with blood culture and respiratory tract isolate data derived from > 400 groups from >250 infection prevention studies.ResultsIntroducing interaction terms between Candida colonization and each of Staphylococcus aureus (coefficient +0.34; 95% confidence interval 0.19 to 0.48) and Enterococcal (+0.55; 0.23 to 0.86) colonization (all as latent variables) improved the fit for each model. The magnitude and significance level of the interaction terms were similar to the positive associations between exposure to topical antibiotic prophylaxis (TAP) on Enterococcal (+0.52; 0.06 to 1.0) versus the negative association with Staphylococcus aureus (-0.42; -0.66 to -0.17) colonization.ConclusionsGSEM modelling of published ICU infection prevention data implies interactions between Candida and Gram-positive bacteria in the human microbiome. This interaction might also account for the paradoxically high incidences among studies of TAP in ICU patients.
Habitat Patch Metrics for Restoring Species Flow in Urban Context; Special Reference to Fragmentation of Colombo Wetlands, Sri Lanka.
Authors: Ekanayake Maheshika 
Published: May 2021

Abstract
BackgroundColombo wetlands (CW) are the last ecological frontier of the Sri Lankan National capital. CW network has Classified as the most vulnerable ecosystem under the Ramsar convention which suffered from severe fragmentation due to human encroachments and urban densifications. Over the past few decades, 31% of habitat loss resulted in the dislocation and extinction of many species in the wetland forest. Currently, restoration efforts are taking place to rehabilitate the ecology through wetland parks and ecological patches. However, promotion of the species movement is not evident through the development of isolated patches due to fewer considerations of the connectivity in the Urban matrix. Therefore, management of ecological network connectivity is a predominant measure to rehabilitate the CW habitats. Even though the literature suggests that patch metrics are a vital threshold to predict the species flow rates, lack of scientific research involved in such phenomenon in Sri Lanka. Thus, this study experimentally investigates the role of ecological patch metrics towards connectivity index in Colombo urban wetlands. The study equips remote sensing data 2018 to calculate the wetland patch metrics (Configuration) of Total area (TA), Total edge (TE), Shape Index (SI), Core area index (CAI), and Inter-patch distances (IPD) for 3 sample locations. GIS modeled Least cost paths within CW boundaries are acquired to calculate the Species flow Index (SFI) per patch for common species. ResultsThe Pearson correlation test explicitly proves that (P< 0.05) the SFI co-related with TA, TE, CAI, and IPD. A strong positive correlation was observed in patch metrics of TA, TE, and CAI and a strong negative in IPD against SFI. Furthermore, based on connectivity contributions, the study proposed three wetland patch classifications as open patches, closed patches, and active patches the which are rated upon the species flow. ConclusionIn city-level implications, improvement of total area, perimeter, and reduction of interpatch distance for “active wetland patch” will result in re-gaining the species flow for Colombo wetlands. The overall study is an applied model for restoring urban ecological networks to gain maximize connectivity index to preserve species richness in urban ecological networks.
Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
Authors: Kumar Nitya , AbdulRahman AbdulKareem , AlAwadhi Abdulla , AlQahtani Manaf 
Published: May 2021

Abstract
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death – all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p=0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds Ratio: 0.40, 95% confidence intervals: 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association.
Quantitative Determination of Quercitrin Levels in Rat Plasma Using
UHPLC-MS/MS and its Application in a Pharmacokinetic Study after the
Oral Administration of Polygoni cuspidati Folium Capsules
Authors: Ma Shi-tang , Zhang Xin-yuan , Zhang Ning , Bi Xiao-lin , Feng Cheng-Tao 
Published: May 2021

Background:
Quercitrin is widely found in herbal medicines, and it is particularly important
in the design of new therapeutic agents. Because of its wide range of biological activities, methods for
detecting quercitrin and its pharmacokinetics in biological samples must be investigated.

Objective:
To develop and validate a sensitive and reliable ultra-high-performance liquid chromatography-
tandem mass spectrometry (UHPLC-MS/MS) method for the quantitative determination of quercitrin
levels in rat plasma, and test its application in a pharmacokinetic investigation after the oral administration
of Polygoni cuspidati folium capsules (HC).

Methods:
First, a rapid analytical method implementing UHPLC-MS/MS for the quantification of quercitrin
levels in rat plasma was developed and validated. The analyte and internal standard (IS) tinidazole
were extracted from rat plasma via protein precipitation with 800 μL of methanol and 50 μL of 1% formic
acid solution. Chromatographic separation was performed using an Agilent ZORBAX C18 column
within 4 min. Mass spectrometry was performed for quantification using a triple-quadrupole mass spectrometer
employing electrospray ionization in the negative ion mode. The MRM transitions for quercitrin
and IS were m/z 447.2→229.9 and m/z 246.0→125.8, respectively. The UHPLC-MS/MS method
for the quantitative determination of quercitrin levels in rat plasma was then applied to investigate its
pharmacokinetics after the oral administration of HC in rats.

Results:
The developed UHPLC-MS/MS method for detecting quercitrin in rat plasma was linear over
the range of 0.1–160 ng/mL. The linear regression equation was Y = (0.7373 ± 0.0023)X − (0.0087 ±
0.0021) (r2 = 0.9978). The intra- and interday precision values were within 7.8%, and the recoveries of
quercitrin and IS exceeding 67.3%. The UHPLC-MS/MS method was successfully applied to characterize
the pharmacokinetic profile of quercitrin in eight rats after the oral administration of HC. The experimentally
obtained values were fit to a one-compartment, first-order pharmacokinetic model, and they
appeared to fit the concentration–time curve.

Conclusion:
Quercitrin was proven to be stable during sample storage, preparation, and the analytical
procedures. The pharmacokinetic parameters suggested that quercitrin may be present in the peripheral
tissues of rats.
Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization
Authors: Tanaka Miruto , Inoue Yuki , Imai Takahiko , Tanida Norifumi , Takahashi Koichi , Hara Hideaki 
Published: May 2021

Background:
Neovascular age-related macular degeneration (AMD) with choroidal neovascularization
(CNV) is a leading cause of blindness in elderly people. Anti-vascular endothelial
growth factor (anti-VEGF)-drugs are used to treat AMD patients; however, some patients are resistant
to these therapies.

Objective:
The purpose of this study was to investigate the anti-angiogenic effects of α2-adrenergic
agonists, including guanabenz and clonidine.

Methods:
We evaluated the anti-angiogenic effects of α2-adrenergic agonists in human retinal microvascular
endothelial cells (HRMECs). A proliferation assay was conducted, and the migration
ratio was evaluated. In a laser-induced CNV model, guanabenz and clonidine were delivered via intraperitoneal
injection or implantation of an osmotic pump device. Fourteen days following CNV
induction, CNV lesion size and fundus fluorescein angiography (FFA) were evaluated.

Results:
Guanabenz and clonidine inhibited VEGF-induced retinal endothelial cell growth and migration.
In the CNV model mice, CNV lesion sizes were reduced by intraperitoneal administration
of guanabenz or clonidine. Data, including body weight, systolic blood pressure, and heart rate
showed that guanabenz (0.5 and 2.0 mg/kg/day) had little effect on these parameters; conversely, a
high dose of clonidine (1.0 mg/kg/day) did affect these parameters. Additionally, clonidine did not
affect CNV size, but continuous administration of guanabenz attenuated both CNV size and leakage
from neovessels.

Conclusion:
Our study suggests a key role for α2-adrenergic receptors during CNV formation.
Therefore, we suggest that α2-adrenergic receptor agonists may represent novel therapeutic drugs
for patients with neovascular AMD.
Detection of Cognitive Impairment by Choice Auditory Reaction Time
(ART) and Visual Reaction Time (VRT)s during Acute Mental Stress in
Young Hypertensives: A Case Control Study
Authors: Khode Vitthal , Patil Satish , Babu Girish , Ruikar Komal , Patel Sakshi 
Published: May 2021

Background:
Acute stress is known to be associated with both negative and positive influences
on cognitive performance. Hypertension is one of the risk factors for lowered cognitive
performance. Mental stress testing is easier to administer and can be regulated by the investigator.
Mental arithmetic using serial subtraction is the most widely used method to administer stress. Reaction
time (RT) is widely used to assess cognitive domains like attention, execution and psychomotor
speed. Researchers have shown choice reaction times are delayed in hypertension. It is not
known whether acute mental stress improves or deteriorates attention, execution and psychomotor
speed in hypertension. We hypothesized in the present study that acute mental stress deteriorates
cognitive function in hypertensives without overt cerebrovascular disease or other vascular risk factors.

Method:
After getting medical ethical clearance from our institution, this case-control study was
carried out over eight months (January 2017 to September 2017). 60 subjects between the age
group of 35 to 55 years were included in the study. They were divided into 2 groups. Group 1 consisted
of 30 diagnosed cases of hypertension at least two years of duration. Group 2 consisted of 30
sex and age-matched controls. MMSE was performed to assess the cognitive function in these
groups. Simple (S) and choice (C) auditory reaction time (ART) and visual reaction time (VRT)s
were measured at rest and acute mental stress in these groups to assess cognitive function. Predictive
value of VRTC resting and VRTC during acute mental stress among hypertensives for cognitive
dysfunction was calculated using the receiver operating characteristic (ROC) curve.

Results:
There was significant difference ART and VRT, both simple and choice, in hypertensive
and nonhypertensive subjects and these reaction times further increased during mental stress
(P<0.001). VRTC can be a predictor of cognitive dysfunction in hypertensives and during acute
mental stress.

Conclusion:
A significant difference in cognitive functions in hypertensive and nonhypertensive
subjects exists and this further deteriorates with acute mental stress.
Assessing the Post-Earthquake Temporary Accommodation Risks in Iran Using Fuzzy Delphi Method
Authors: Dabiri Mostafa , Oghabi Mohsen , Sarvari Hadi , Sabeti Mohammad S. , Kashefi Hamidreza , Chan Daniel W.M. 
Published: May 2021

Background:
The process of temporary accommodation after an earthquake is one of the most important issues in crisis management.

Objective:
This research study attempts to identify and prioritize the key risks inherent with the post-earthquake temporary accommodation process in Sanandaj, Iran using the Fuzzy Delphi method.

Methods:
To achieve this goal, first, we examined the previous research on the issue of temporary accommodation after earthquakes and other disasters worldwide in order to determine the current important challenges. Then, the opinions of crisis management experts in 11 areas and 94 questions in the form of Fuzzy Delphi survey questionnaire with Five-point Likert measurement scale were used to rank these challenges. The Delphi panel participants, who responded to the Fuzzy Delphi questionnaire, consisted of 18 experts related to crisis management in executive organizations of Kurdistan province.

Result:
After performing the steps of the fuzzy Delphi method, a basket of important risks in the temporary accommodation process were identified qualitatively and quantitatively, and were prioritized in order of relevance and significance. The results showed that climatic challenges have the highest potential of post-earthquake temporary accommodation risk in the region among of the 11 major risk areas under examination.

Conclusion:
The study’s findings and recommendations can serve as a policy instrument and consultative toolkit for relevant stakeholders.