bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study
Authors: Zhou Jiaolin , Zhao Zichen , Sun Tao , Liu Wei , Yu Zhongxun , Liu Jingjuan , Yu Yiqi , Ning Shoubin , Zhang Hongbing 
Published: January 2021

INTRODUCTION:
Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic venous malformation (VM) disease. The characteristic gastrointestinal (GI) bleeding from multiple VM lesions causes severe chronic anemia which renders most patients depend on lifelong blood transfusion and frequent endoscopic treatment with dismayed outcomes. Although recent case reports suggest that oral sirolimus (rapamycin) is effective, a comprehensive evaluation of its efficacy and safety is in need.

METHODS:
A prospective study was conducted for both pediatric and adult BRBNS patients with administration of sirolimus at the dose of 1.0 mg/m2 to maintain a trough concentration of 3–10 ng/mL. Laboratory tests including complete blood count, biochemical profile, D-dimer, and whole-body magnetic resonance imaging were performed at baseline and 3, 6, and 12 months after treatment. Clinical indicators such as hemoglobin level, lesion size, and transfusion need were evaluated. Adverse effects were recorded regularly.

RESULTS:
A total of 11 patients (4 males and 7 females) with median age of 14 (range, 5–49) years were recruited. The average lesion size was reduced by 7.4% (P < 0.001), 9.3% (P < 0.001), and 13.0% (P < 0.05) at 3, 6, and 12 months of sirolimus treatment, respectively. Hemoglobin increased significantly after 6- and 12-month treatment (P = 0.006 and 0.019, respectively). Only 1 patient received blood transfusion once during the study. Patients' quality of life and coagulation function were improved. Grade 1–2 adverse effects including oral ulcers (81.8%), acne (27.3%), transient elevation of liver enzymes (18.2%), and hair loss (9.1%) were observed.

DISCUSSION:
Sirolimus reduces the size of VMs, alleviates GI bleeding, and eliminates transfusion dependence of patients with BRBNS. The drug-related adverse effects are mild and mostly self-limited. These findings support sirolimus as a first-line treatment for GI and cutaneous VMs of BRBNS (see Visual abstract, Supplementary Digital Content, http://links.lww.com/AJG/B819).
Paisaje construido y sustentabilidad urbana Huellas identitarias del paisaje moderno El Plan de Transformación de Osorno
Authors: Weibel Fernández Hugo Eduardo 
Published: January 2021

Se aborda el estudio de las huellas arquitectónicas y urbanas modernas con relación al paisaje contemporáneo de Osorno, Chile, en orden a comprender las implicancias actuales de sus rasgos distintivos, desde una perspectiva de desarrollo sostenible.
Fundados en Hiernaux, Mondragón y Aliste y mediante documentación de época, se interpreta el Plan de Transformación de Osorno (1930) en ámbitos de espacio público y modos edificatorios. Paralelamente, se realiza registros fotográficos intencionados de las huellas modernas de dicho Plan presentes en la urbe contemporánea. Con la información obtenida se interpreta críticamente la situación de dichas huellas en relación al contexto contemporáneo, concluyendo que el Plan de Transformación de Osorno propuso una vía modernizadora no rupturista que, junto con mantener vínculos con la herencia local, factibilizó materializar prácticas arquitectónicas y urbanas modernas, con énfasis en espacios públicos, cuyas huellas, aún relevantes en la ciudad, han asistido a la evolución sustentable de Osorno.
Optimization of erosion wears of Al–Mg–Si–Cu–SiC composite produced by the PM method
Authors: Behera Rajesh Kumar , Samal Birajendu Prasad , Panigrahi Sarat Chandra , Das Sudhansu Ranjan 
Published: January 2021

Abstract
Metal matrix composites are expanding their range every day due to their various industrial applications in manufacturing sectors, to attain high performance and favorable characteristics such as light weight, more excellent corrosion as well as wear resistance, high specific strength and high temperature-resistance than conventional materials. This study deals with analysis on erosion wear characteristic and corrosion behavior of newly-engineered aluminum metal–matrix composite (Al–0.5Si–0.5Mg–2.5Cu–5SiC) developed by powder metallurgy method. Solid particle erosion test was conducted on the newly developed AMMC product and the execution of design of experiments through Taguchi and statistical techniques demonstrates the feasibility of investigating the erosion characterization and behaviors of the composites. Sixteen set of experimental trials were performed by considering three process parameters (impact angle, stand-off distance, and impact velocity) associated with four levels each. Experimental results in accordance of Taguchi’s orthogonal array design of experiments are analyzed by employing analysis of variance (ANOVA), response surface methodology (RSM) and desirability function approach for analysis, predictive modeling and optimization of erosion rate, respectively. Thereafter, an observation on eroded surface morphology is performed under the influence of impact velocity by employing scanning electron microscope (SEM) to entrench the process. Result shows that, the impact velocity followed by impact angle have significant contribution (80.42 and 8.71%, respectively) in improvement of erosion rate. The methodology proposed in this study collects the experimental results and builds a mathematical model in the domain of interest and optimized the process model. Under the highest desirability (1), desirability-function approach of RSM presented the optimal manufacturing conditions at impact velocity of 18 m/s, stand-off distance of 26 mm and impact angle of 67° with estimated erosion rate of 65.155 mg/kg. The experimental data generated for Al–0.5Si–0.5Mg–2.5Cu–5SiC AMMC will be useful for the industry.
Platforms and Potency: Democracy and Collective Agency in the Age of Social Media
Authors: Gilbert Jeremy 
Published: January 2021

AbstractAttitudes to digital communication technologies since the 1990s have been characterized by waves of optimism and pessimism, as enthusiasts have highlighted their democratic and liberating potentials, while critics have pointed to the socially, politically and psychologically deleterious consequences of unchecked digital capitalism. This paper seeks to develop an analytical framework capable of appreciating and assessing the capacities of such technologies both to genuinely enhance democratic agency, and to become tools through which capitalist power is enhanced with widespread negative consequences. The paper in particular deploys my concept of ‘potent collectivity’ in order to name the type of democratic agency that such media technologies can be seen both to enable and enhance under certain circumstances, and to inhibit under others. It also considers the affective qualities of ‘potent collectivity’, and in particular the utility of a Deleuzo-Spinozan concept of ‘collective joy’ as designating the affective quality typical of ‘potent collectivity’. The paper uses the specific example of left-wing political activism in the UK during the period 2015-17 to illustrate the potential for platform technologies to enable new forms of democratic mobilization, while arguing for an analytical position that eschews any simple celebration of the liberating potential of new technologies; remaining sensitive to the negative features of ‘platform capitalism’.
Spherical approximating and interpolating moving least squares in geodesy and geophysics: a case study for deriving gravity acceleration at sea surface in the Persian Gulf
Authors: Kiani M. 
Published: January 2021

AbstractThis paper is aimed at introducing the concept of Spherical Interpolating Moving Least Squares to the problems in geodesy and geophysics. Based on two previously known methods, namely Spherical Moving Least Squares and Interpolating Moving Least Squares, a simple theory is formulated for using Spherical Moving Least Squares as an interpolant. As an application, a case study is presented in which gravity accelerations at sea surface in the Persian Gulf are derived, using both the approximation and interpolation mode of the Spherical Moving Least Squares. The roles of the various elements in the methods-weight function, scaling parameter, and the degree of spherical harmonics as the basis functions-are investigated. Then, the results of approximation and interpolation are compared with the field data at sea surface, collected by shipborne gravimetry approach. Finally, the results are compared with another independent interpolation method-spline interpolation. It is shown that in this particular problem, SMLS approximation and SIMLS interpolation present a better accuracy than spherical splines.
Why linguistic entrepreneurship?
Authors: De Costa Peter I. , Park Joseph Sung-Yul , Wee Lionel 
Published: January 2021

AbstractThis introduction builds on De Costa et al.’s (2016], [2019) notion of linguistic entrepreneurship, which is defined as “the act of aligning with the moral imperative to strategically exploit language-related resources for enhancing one’s worth in the world” (2016: 696). The four empirical studies and two critical commentaries that constitute this special issue explain the relevance of this construct and explore how it is instantiated in a range of formal and informal educational contexts across the world. Specifically, we explain how linguistic entrepreneurship serves as a unique and innovative contribution to the existing body of sociolinguistics, applied linguistics, and language policy research on neoliberalism.
Formation of laser-induced periodic surface nanometric concentric ring structures on silicon surfaces through single-spot irradiation with orthogonally polarized femtosecond laser double-pulse sequences
Authors: Liu Wei , Hu Jie , Jiang Lan , Huang Ji , Lu Jiangang , Yin Jiangang , Qiu Zhaoling , Liu Hailin , Li Chen , Wang Suocheng , Wang Shaojun 
Published: January 2021

Abstract
In this study, we report the formation of laser-induced periodic surface nanometric concentric ring structures on silicon surfaces through single-spot irradiation with orthogonally polarized femtosecond laser double-pulse sequences (OP pulses). The period of the ring structures is marginally smaller than the irradiated laser’s wavelength, which indicates that the structures are a type of low-spatial-frequency laser-induced periodic surface structures. Regular nanometric concentric ring structures can be formed when the time delay between two subpulses is approximately 1 ps (roughly from 500 fs to 1.5 ps) and the number of laser bursts is approximately 4. The formation mechanism of the concentric ring structures is attributed to the surface wave (i.e., cylindrical wave) stimulated by OP pulses through single-spot irradiation is radially distributed. Large area of concentric ring structures eliminating anisotropy in the generation of structural colors was shown in this paper.
The crystal structure of trimethylsulfonium tris(trifluoromethylsulfonyl)methanide, C7H9F9O6S4
Authors: Wirthensohn Raphael , Finze Maik 
Published: January 2021

Abstract
C7H9F9O6S4, orthorhombic, P212121 (no. 19), a = 8.80180(10) Å, b = 10.96580(10) Å, c = 16.91360(10) Å, V = 1632.48(3) Å3, Z = 4, R

gt
(F) = 0.0222, wRref
(F
2) = 0.0604, T = 100 K.
Independent Sector: Preserving the Status Quo?
Authors: Williams Andrew L. , Doan Dana R. H. 
Published: January 2021

Abstract
In October of 1978, a committee met to explore the possibility of a merger between the National Council on Philanthropy (NCOP) and the Coalition of National Voluntary Organizations (CONVO). The vision was more than the mere marriage of two small organizations facing uncertain futures. Participants in this endeavor dreamed of an entity that would represent the entire nonprofit sector. The organization they birthed in 1979, Independent Sector (IS), was a meaningful step forward in unifying the sector. The IS board represented a broad range of sub-sectors and causes and also made strides in gender and, to a lesser extent, racial and religious diversity. Yet, there was an inherent tension in the project. Yes, it was true that people did not want to “interfere with pluralism” but they also wanted “a strong voice” to champion the sector—those involved called this dilemma a “persistent contradiction.” The tension was resolved in favor of the concerns of the powerful national non-profit institutions and foundations: tax policy, government relations, and sector advocacy. That is, the umbrella organization acted principally to preserve the sector, as constituted, and had little appetite for structural reform or discussion of competing notions of “the good” within the sector. Critics pointed to the exclusion of local organizations fighting issues that challenged societal injustice and inequitable distribution of power and resources. To them, and in retrospect to the authors of this paper, greater sector “unity” entailed consolidation of traditional power and continued marginalization of communities already on the periphery. Though four decades have passed, the same tension remains in the philanthropic sector. Contest and division between various interests and constituencies is as evident now as it was then. Enthusiastic support for the advancement of public goods often over-shadows issues of power—including the ability to impose one’s own definition of the public good on others. This critique has been leveled forcefully in recent years. Is it possible or even desirable to seek greater unity for the public good? Whose voices are privileged in the quest for greater sectoral unity? These are the questions this paper aspires to provoke and inform by examining the founding of the first major nonprofit sector association in the United States.
The Concept of Telicity in English, Romanian and Serbian
Authors: Lazović Mihaela 
Published: January 2021

AbstractGiven that the notion of telicity was simply defined by English linguists as a situation which tends towards a goal, this paper will additionally explain and define telicity in the English language. Moreover, the issue of telicity in the Serbian and Romanian relevant linguistic literature has been scarcely analysed. This paper aims to ascertain and define telicity as an indispensable semantic characteristic of Serbian and Romanian verbs. Since the paper proves that the concept of telicity can be detected in languages other than English, telicity can and should be considered a linguistic universal.
Development and Experimental Research of Multimedia CAI Courseware for Hurdle Running
Authors: Zhang Dengfeng , Li Fanghui , Zhang Xinkai 
Published: January 2021

Abstract
As a very important achievement in education in the 21st century and the crystallization of human wisdom, computer-aided instruction (CAI) has become an important part of educational science and modern educational technology and also the direction of teaching reform in the future. It takes computer as a new medium and integrates image, sound, text, video, audio, animation, and other multimedia information through computer to make it possible. A large amount of information is needed to establish a reasonable connection so as to integrate the technology of an interactive teaching system. So far, although there have been many CAI courseware achievements, and they have far-reaching influence in various teaching fields, there are few CAI teaching and research achievements related to sports, especially in the hurdle race of track and field. Through experimental research, it is proved that multimedia-assisted hurdle teaching is superior to traditional teaching in understanding basic theories and concepts, mobilizing multisensory learning, and enhancing memory, which is more conducive to improving students’ enthusiasm and initiative in learning and mastering theoretical knowledge and technical skills than traditional teaching. Therefore, the development of multimedia CAI courseware for hurdle race is of great significance, and it also provides some reference experience and mode for other sports teaching courseware.
Mapping Sex-Specific Neurodevelopmental Alterations in Neurite Density and Morphology in a Rat Genetic Model of Psychiatric Illness
Authors: Barnett Brian R. , Yi Sue Y. , Poetzel McKenzie J. , Dodd Keith , Stowe Nicholas A. , Yu John-Paul J. 
Published: January 2021

AbstractNeurite orientation dispersion and density imaging (NODDI) is an emerging magnetic resonance (MR) diffusion-weighted imaging (DWI) technique that permits non-invasive quantitative assessment of neurite density and morphology. NODDI has improved our ability to image neuronal microstructure over conventional techniques such as diffusion tensor imaging (DTI) and is particularly suited for studies of the developing brain as it can measure and characterize the dynamic changes occurring in dendrite cytoarchitecture that are critical to early brain development. Neurodevelopmental alterations to the diffusion tensor have been reported in psychiatric illness, but it remains unknown whether advanced DWI techniques such as NODDI are able to sensitively and specifically detect neurodevelopmental changes in brain microstructure beyond those provided by DTI. We show, in an extension of our previous work with aDisc1svΔ2 rat genetic model of psychiatric illness, the enhanced sensitivity and specificity of NODDI to identify neurodevelopmental and sex-specific changes in brain microstructure that are otherwise difficult to observe with DTI and further corroborate observed changes in brain microstructure to differences in sex-specific systems-level animal behavior. Together, these findings inform the potential application and clinical translational utility of NODDI in studies of brain microstructure in psychiatric illness throughout neurodevelopment and further, the ability of advanced DWI methods such as NODDI to examine the role of biological sex and its influence on brain microstructure in psychiatric illness.
XI.—Romance Etimologies
Authors: Rice Carl C. 
Published: January 2021

Revewers hav not accuratly appraisd my Etimology ov the Romance Words for To Go. Inasmuch as the article appeard in 1904 and contributions to the subject seem rather scarce nowadays, I propose to take up the subject again.I will express no opinion ov Horning's essay. He merely refers to a detail ov my article in a foot-note. Elise Richter has lately written ov “the solution ov the andare problem, which Horning sturdily attacks and which he has eminently advanst.” Just how, she does not say. But we used to hear ov la question ambulare, point-blank; so somhow a little ground is being gaind, whoever gets the credit. Schuchardt seems to abandon his monogenetic scheme by admitting that his tipe ambitare may be connected with ambire rather than with ambulare.
A Byzantine Source for Guillaume de Lorris's Roman de la Rose
Authors: Warren F. M. 
Published: January 2021

The poet of the Roman de la Rose dreamed one May morning that he came to a park wall decorated with allegorical representations of vices and defects. And when he entered the park he found there a company of dancers, whose individual members also represented different human attributes. With this company was the God of Love, and his attendant who carried his bows and arrows. So that when the dances had ended and the poet went on to explore the park, the god and his squire followed him. They soon found a spring, bubbling up under a pine, with a curb on which was written: “Here the beautiful Narcissus died.” In the spring's depths they could see two stones, like crystal, that changed their color under the sun's rays and reflected all the park round about. This was the water where Cupid had sowed the seeds of love, the famous Fountain of Love,Dont plusors ont en maint endroitParlé, en romans et en livre. (Il. 1606, 1607)
XVI.—The Troilus-Cressida Story From Chaucer to Shakespeare
Authors: Rollins Hyder E. 
Published: January 2021

Viewed from any angle Shakespeare's Troilus and Cressida is an unattractive play. The heroine is a wanton. Ulysses reads her at a glance and finds
language in her eye, her cheek, her lip,Nay, her foot speaks; her wanton spirits look outAt every joint and motive of her body.He sets her down at once as “a daughter of the game,” and at every opportunity the foul-mouthed Thersites corroborates this description. “They say Diomedes keeps a Trojan drab,” he monologizes, “and uses the traitor Calchas his tent. I'll after; ”2 and in the rather awkward scene in which Cressida's perfidy is revealed to Troilus, he gleefully whispers: “Any man may sing her, if he can take her cliff. She's noted.”
Doctor Faustus and A Shrew
Authors: Houk Raymond A. 
Published: January 2021

This study of Christopher Marlowe's The Tragicall Historie of Doctor Faustus and The Taming of a Shrew is related to the preceding study on “Shakespeare's Shrew and Greene's Orlando” in that both involve parallels between A Shrew and contemporary plays—parallels which have been thought by H. D. Sykes and others to involve Samuel Rowley in the rôle of a contributor to each. Instead of such a common author a theory of common sources in earlier versions of the plays is herein maintained. Shakespeare is apparently not involved in these parallels with Doctor Faustus either as the author of The Taming of the Shrew or as the probable author of the original version of the play.The parallels with A Shrew which are herewith cited seem to call for a theory of a common source in an earlier form of Doctor Faustus than the 1604 and 1616 texts.1
Empathic Imagery in Keats and Shelley
Authors: Fogle Richard H. 
Published: January 2021

Empathy, the involuntary projection of oneself into an object, received its first extended formulation in the Mikrokosmos of Hermann Lotze (1858). To Lotze Einfühlung, or empathy as it has been termed in English, was a phenomenon which accounts for our knowledge of the external world. “The world,” he said, “becomes alive to us through this power to see in forms the joy and sorrow of existence that they hide: there is no shape so coy that our fancy cannot sympathetically enter into it.” In this knowledge our consciousness of our own bodily sensations is a factor: “Unquestionably the vividness of these perceptions is added to by our abiding remembrance of the activity of our own body … every movement which we execute, every attitude in which we repose, has its meaning rendered plain to us by the feeling of exertion or of enjoyment.” Entering thus into our own sensations, by means of them we are also enabled to know the feelings of creatures and objects beyond their immediate range:… we, thus aided by our sentience, assuredly can comprehend also the alien silent form. Nor is it only into the peculiar vital feelings of that which in nature is near to us that we enter into the joyous flight of the singing bird or the graceful fleeting of the gazelle; we not only countract our mental feelers to the most minute creatures, to enter in reverie into the narrow round of existence of a mussel-fish and the monotonous bliss of its openings and shuttings, we not only expand into the slender proportions of the tree whose twigs are animated by the pleasure of graceful bending and waving; nay, even to the inanimate do we transfer these interpretative feelings, transforming through them the dead weights and supports of buildings into so many limbs of a living body whose inner tensions pass over into ourselves.