bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of methods for assessing the effectiveness of dedicated lanes for public transport
Authors: Fornalchyk Yevhen , Vikovych Ihor , Royko Yurii , Hrytsun Oleh 
Published: March 2021

There are different configurations of street and road networks in cities, which is why those transportation models that determine how effectively a public transport network is operated are different. Along with this, some transport areas may have characteristic features predetermined by the density of a street network, the intensity of individual and public traffic. The special feature of the current study is determining the operational effectiveness of dedicated lanes for public transport given a significant density of the main street and road network. Significant density is characterized by its value for the distance between adjacent intersections in the range of 150‒200 m. With such planning patterns, there is a mutual influence of the conditions of individual and public transport between adjacent intersections. An increase in the distance between intersections disrupts the stability of traffic flow through its disintegration into separate groups based on the dynamic characteristics of vehicles.
A characteristic feature of the proposed procedure for evaluating the operational effectiveness of dedicated lanes is that the use of a GPS monitoring system makes it possible to relatively quickly determine the areas of the network where there are the greatest delays in movement in real time. After that, attention is focused on investigating the main factors of influence and their parameters followed by modeling.
The reported results would in the future contribute to devising a clear sequence of transport-related research based on a set of their methods in order to acquire representative data and define adequate patterns. An important practical result is the use of not only established normative approaches to the design of dedicated lanes, which are common for all types of street and road networks but taking into consideration the peculiarities characteristic of their individual sections.
Development of a method for obtaining a CdS/CdTe/Cu/Au module on a flexible substrate designed for backup supplying systems prevention of emergency situations
Authors: Deyneko Natalia , Yeremenko Sergey , Kamyshentsev Gennady , Kryvulkin Igor , Matiushenko Mykola , Myroshnyk Oleg , Pruskyi Andrei , Soshinsky Alexander , Strelets Victor , Shevchenko Roman 
Published: March 2021

The study of methods for obtaining base layers of cadmium telluride for the creation of efficient solar cells on a flexible substrate, intended for backup power supply of security systems and facility control. Considering that the polyamide film is stable up to a temperature of 450 °С, the formation of the base layers of solar cells based on cadmium telluride on flexible polyamide substrates was carried out by the method of DC magnetron sputtering. Using the chosen method, experimental samples of micromodules on a flexible substrate with series-connected solar cells based on CdS/CdTe/Cu/Au were obtained. To understand the effect of the failure of one or more solar cells on the efficiency of the entire micromodule during operation, an analysis of the initial parameters and light diode characteristics of individual solar cells of micromodules was carried out. The design of the micromodules, in which the solar cells were connected in series, made it possible to separately measure their output parameters. It was found that the creation of a Cu/Au rear tunnel contact made it possible to obtain high values of the output parameters for individual solar cells, but the micromodule contains a limitation by a shunted solar cell. However, the greatest role in reducing the efficiency of the entire micromodule is played by ineffective absorption of radiation when passing through the polyamide film, which led to a decrease in the efficiency of the entire micromodule, in which there is a shunted element, to 3.9 %. The maximum efficiency of the obtained samples of micromodules was 5.3 %
Stress response and state of cognitive functions in the perioperative period in elderly patients during laparoscopic cholecystectomy
Authors: Bielykh Olena , Georgiyants Marine , Vysotska Olena , Strashnenko Anna 
Published: March 2021

The aim. To investigate the dynamics of stress markers and the state of cognitive functions in the perioperative period during laparoscopic cholecystectomy in elderly patients.
Materials and methods. We examined 84 patients aged 68.1 ± 0.6 years, with diagnosed gallstone disease, acute cholecystitis, who underwent laparoscopic cholecystectomy. Patients were randomized into 2 groups: Group I - inhalation anesthesia based on sevoflurane with mechanical ventilation; Group II - TBA based on propofol with mechanical ventilation. Hemodynamic parameters, dynamics of stress markers (cortisol, insulin, glucose) and cognitive function were investigated.
Results. Glucose and insulin levels in both groups remained within normal limits at all stages of the study. The baseline cortisol level was higher than normal in both groups, but at 4, 5, 6 stages of the study decreased significantly compared with baseline values (p<0.001).
In the study of cognitive functions by the Luria test and the MMSE scale, a significant decrease was found in both groups on the day after surgery.
According to the Luria test, the score in group I significantly decreased the day after surgery against the period before premedication by 8.7% (p<0.001), in group II - by 10.1% (p<0.001); according to the MMSE scale, the score in group I significantly decreased on the day after surgery against the period before premedication by 6.0% (p<0.001), in group II - by 6.3% (p<0.001).
On the fifth postoperative day, no significant differences in baseline values ​​between the Luria test and the MMSE scale were detected.
Conclusions. The comparative analysis of the dynamics of stress marker levels in both groups revealed some advantages of general sevoflurane-based anesthesia in antistress protection of patients in the perioperative period during laparoscopic cholecystectomy compared with total intravenous anesthesia based on propofol. However, the effectiveness of anti-stress protection of both types of anesthesia was sufficient.
According to the correlation analysis, an inverse correlation was found between the state of cognitive functions in the postoperative period and the level of cortisol in the intraoperative period
Determination of features of development of modern theories of management
Authors: Zhaldak Hanna 
Published: March 2021

The object of research is the processes of development of modern management theories. One of the next problematic aspects is the identification of the peculiarities of the development of modern management theory in the period of digitalization and pandemic, which means a significant impact on the economy.
In the process of work general scientific methods were used: induction and deduction, analysis and synthesis, comparison, systematization. The analysis of scientific approaches to the definition of management is carried out; the main essential features of modern enterprises and management theories, respectively, are determined. It is determined that the theory of management at the present level undergoes significant transformations. In modern theories more and more attention is paid to: the intangible component and the peculiarities of its management; there is an active transition to digital technologies and digitalization of business; there is a need to use new management methods; organizational structures and corporate cultures are changing. This in turn contributes to the purposeful formation and development of such institutions within the organization as:
– trust and creative atmosphere of productive group work;
– development of organizational ties within the organization and outside it;
– development of innovative ability of the company’s staff;
– use of experience of other organizations.
Based on the analysis, the following features of modern management theories are identified:
– in modern theories more and more attention is paid to the intangible component and the peculiarities of its management;
– active transition to digital technologies and digitalization of business;
– change in the subject of work in most employees, in particular, the transition to advanced information and communication technologies;
– the need to use new management methods;
– transformation of organizational structures and corporate cultures. This provides the possibility of effective modern management by planning the activities of the firm in the short, medium and long term, as well as obtaining the maximum possible profit with minimal costs in a rapidly changing environment.
Assessment of the current state of the use of non-monetary methods of state regulation of financial recovery of banks
Authors: Stadniychuk Roman 
Published: March 2021

The object of research is the processes of state regulation of financial recovery of banks by non-monetary methods. One of the most problematic areas is determining the practical aspects of regulating the financial recovery of banks by non-monetary methods, which include:
– establishment of mandatory requirements for banking services and business processes;
– carrying out checks and taking measures in the event of a violation;
– establishment of methods of organizing or conducting banking activities in the process of financial recovery;
– licensing rules. An important aspect is the identification of factors that exacerbate the problems of the banking system, in particular, lead to large-scale lending to related parties; opaque ownership structure; inaccurate financial statements; fictitious accounts in foreign banks; money laundering and the like. Improvement of state regulation of financial recovery of banks through the use of preventive measures is possible with the effective use of non-monetary methods of such regulation.
The study used methods of analysis and synthesis, induction and deduction, methods of systematization and comparison, tabular and graphical methods. The composition of monetary instruments and their features have been determined. The proposed measures for non-monetary regulation of financial recovery of banks are related to:
– improving the procedure for disclosing information on the ultimate owners of the bank;
– strengthening the responsibility of banks for the results of their activities;
– improving the mechanisms for minimizing credit risks for banks both at the stage of issuing a loan and at the stage of its servicing;
– improving the procedure for financial restructuring of problem assets of banks;
– set of recreational measures to restore the bank’s solvency, prevent bankruptcy or increase its competitiveness.
The use of non-monetary methods of financial recovery and the introduction of the requirements of European legislation into national banking practice testifies to the improvement of state regulation of financial recovery of banks, protects them from insolvency and ensures development.
Clinical profile and outcome of dengue fever among children in tertiary care hospital
Authors: Sreedhar S. V. S. , Umamahesh Ramishetty M. 
Published: March 2021

Background: Dengue viral infection is the most common mosquito-borne disease in the world with varied presentations, high morbidity, and high mortality patterns. To study the clinical profile and outcome of dengue fever in children. Methods: This analytical study was conducted in children less than 12 years of age with clinical features of dengue (any acute febrile illness with one of the following: myalgia, headache, retro-orbital pain, bleeding, altered sensorium, shock, or low platelet count) presented at Mahavir institute of medical sciences between February 2019 to January 2020 (12) months were included in the study. Children positive for IgM alone or both IgM and IgG were followed up for a clinical profile.Results: Seizures (9.5%), loose stools (8.5%), lymphadenopathy (15.2%), relative bradycardia (8.5%) were less common manifestations. Rashes were seen in 64.7% of children. Many children in this study were mildly anemic. Mean hemoglobin was slightly higher in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Mean Hb in DSS was 11.28 g%. It was 10.02, 10.1, and 10.45 in DF, DFB, DHF respectively. But it was statistically not significant (P=0.27).Conclusions: Seizure was significant in DSS cases. Any dengue child throwing convulsions should hence be promptly evaluated for an unrecognized shock. The bleeding in dengue is not purely due to thrombocytopenia. There is no role for prophylactic platelet transfusion.
Optimasi Suhu dan Waktu Ekstraksi Akar Pasak Bumi (Eurycoma longifolia jack.) Menggunakan Metode RSM (response surface methodology) dengan Pelarut Etanol 70%
Authors: Anwar Khoerul , Istiqamah Farida , Hadi Samsul 
Published: March 2021

Akar pasak bumi (Eurycoma longifolia Jack.) telah lama dimanfaatkan sebagai obat tradisional oleh masyarakat Indonesia sebagai aprodisiaka. Ekstraksi akar tumbuhan ini dilakukan dengan berbagai pelarut yang salah satunya menggunakan etanol 70%. Pemilihan pelarut ini dilakukan untuk memperoleh kandungan zat berkhasiat semaksimal mungkin yang ditandai dengan rendemen yang tinggi. Penelitian ini bertujuan untuk menentukan suhu dan waktu ekstraksi optimum pada proses ekstraksi akar E. longifolia dengan pelarut etanol 70%. Metode OFAT (One Factor at The Time) digunakan pada uji pendahuluan dan metode RSM (Response Surface Methodology) digunakan pada desain eksperimen dengan bantuan software MINITAB 17. Penelitian dilakukan menggunakan 13 titik perlakuan dengan kombinasi suhu dan waktu yang berbeda. Hasil penelitian menunjukkan bahwa titik optimum rendemen ekstraksi akar E.longifolia sebesar 4,07% diperoleh pada suhu 51,8oC dan waktu 12,13 jam dengan nilai D (desirability) sebesar 0,92. Uji validasi model RSM menunjukkan keakuratan sebesar 97,76%. Model persamaan regresi yang menggambarkan pengaruh suhu dan waktu ekstraksi terhadap rendemen akar E. longifolia adalah Y = - 70,1 + 2,536X1 + 1,387X2 – 0,02389X12 – 0,0464X22 – 0,00500X1X2. Kata Kunci: Eurycoma longifolia Jack., Suhu dan Waktu Ekstraksi, Metode RSM, Etanol 70%The root of the pasak bumi (Eurycoma longifolia Jack.) has long been used as a traditional medicine by the Indonesian people as an aphrodisiac. Extraction of plant roots is carried out with various solvents, one of which uses ethanol 70%. The selection of this solvent was carried out to obtain the maximum possible active metabolite content which is characterized by high yield. This study aims to determine the optimum extraction temperature and time in the root extraction process of E. longifolia with 70% ethanol as solvent. The OFAT (One Factor at The Time) method was used in the preliminary test and the RSM (Response Surface Methodology) method was used in the experimental design with the help of MINITAB 17 software. The study was conducted using 13 treatment points with different combinations of temperature and time. The results showed that the optimum yield point of E. longifolia root extraction was 4.07% at a temperature of 51.8°C and extraction time of 12.13 hours with D (desirability) value of 0.92. The validation test of the RSM model shows an accuracy of 97.76%. The regression equation model that describes the effect of temperature and extraction time on the root yield of E. longifolia is Y = - 70.1 + 2.536X1 + 1.387X2 – 0.02389X12 – 0.0464X22 – 0.00500X1X2.
Evaluasi Mutu Pengelolaan Obat di Instalasi Farmasi Rumah Sakit Umum Imelda Pekerja Indonesia Medan
Authors: Anggraeni Ratih , Gultom Roby Pahala Januario 
Published: March 2021

Pengelolaan obat pada instalasi farmasi rumah sakit merupakan bagian dari pelayanan kefarmasian yang harus terjamin mutunya. Tujuan penelitian ini untuk mendeskripsikan mutu pengelolaan obat di instalasi farmasi Rumah Sakit Umum Imelda Pekerja Indonesia (RSUIPI) Medan. Penelitian ini merupakan penelitian deskriptif periode bulan Maret sampai Mei tahun 2020. Data dikumpulkan melalui wawancara tenaga kefarmasian dan observasi di instalasi farmasi RSUIPI Medan. Indikator aspek pengelolaan obat diukur dari sumber daya manusia, perencanaan obat, pengendalian persediaan obat, penyimpanan obat, serta sarana dan prasarana. Hasil penelitian menunjukkan bahwa perencanaan obat, pengendalian persediaan obat, penyimpanan obat, serta sarana dan prasarana sudah memenuhi ketentuan dalam Permenkes RI Nomor 58 tahun 2014. Walaupun demikian, sumber daya manusia masih belum tercukupi sesuai ketentuan peraturan tersebut. Maka dari itu, kesimpulan dari penelitian ini bahwa mutu pengelolaan obat di instalasi farmasi RSUIPI Medan belum memenuhi ketentuan mutu, terutama pada aspek jumlah SDM. Kata Kunci: pengelolaan obat; instalasi farmasi; apoteker rumah sakit; pelayanan kefarmasian Drug management in pharmacy installation is a part of pharmacy services whose quality must be guaranteed. The purpose of this study was to determine the quality of drug management in the pharmacy installation at the General Hospital Imelda Pekerja Indonesia (RSUIPI) Medan. This study was a descriptive study for the period March-May 2020. Data were collected through interviews with pharmacy personnel and observations at the Pharmacy Installation of RSUIPI Medan. Indicators of drug management aspects are measured from human resources, drugs planning, drug supply control, drug storage, facilities, and infrastructure. The results showed that the drugs planning, controlling drug supply control, drug storage, facilities, and infrastructure had met the requirements in Permenkes RI No 58 (2014). Meanwhile, human resources are still insufficient according to provisions of this regulation. Therefore, the conclusion of this study was that the quality of drug management in the pharmacy installation at RSUIPI Medan has not met the quality requirements, especially in the aspect of the number of human resources.
Analysis of Mineral Density of Calcified Tissues in Children with X-Linked Hypophosphatemic Rickets and Hypophosphatasia Using Cone Beam Computed Tomography Data
Authors: Lezhnev Dmitriy , Vislobokova Elena , Kiselnikova Larisa , Sholokhova Natalia , Smyslenova Margarita , Truten Viktor 
Published: March 2021

The purpose of the present cohort study was a quantitative assessment of the enamel, dentin, and alveolar bone mineral density (BMD) using Cone Beam Computed Tomography (CBCT) scans in patients with X-linked hypophosphatemic rickets (HLHR) and hypophosphatasia (HPP) and a comparison with the data obtained from the control group.	Methods and Results: The unrepresentative, non-random sample included 30 CBCT scans of children with genetically and biochemically confirmed XLHR (OMIM #307800) and HPP (OMIM: 146300, 241510, 241500, and 146300). X-ray examination and dental care were carried out in the Radiology Diagnostics Department and Pediatric Dentistry Department at Moscow State University of Medicine and Dentistry named after AI Evdokimov. The mineral density of calcified tissues (enamel, dentin, and alveolar bone) was evaluated using i-CAT Vision TM software options on reconstructed CBCT axial views.	The images of all XLHR and HPP patients visualized large pulp chambers with prominent pulp horns extending to the dentin-enamel junction. The present study revealed poor alveolar bone mineralization in patients with HPP and XLHR. Analysis of CBCT scans showed a significant dentine hypodensity in XLHR patients, which may contribute to the emergence of multiple, spontaneous, periapical abscesses spreading rapidly in the jawbone. Conclusion: Data obtained could be used for planning dental treatment of patients with XLHR and HPP.
The FTO, PNPLA3 and TM6SF2 Gene Polymorphisms and Genetic Predisposition to NAFLD in Yakut Population
Authors: Diakonova Aleksandra , Kurtanov Khariton , Pavlova Nadezhda , Aleksandrova Tuyara 
Published: March 2021

The aim of our research was to study the distribution of alleles and genotypes of the FTO rs9939609 SNP, the PNPLA3 rs738409 SNP, and the TM6SF2 rs58542926 SNP in the Yakut population. Methods and Results: A total of 85 DNA samples from the population were tested. An analysis of the frequency distribution of alleles and genotypes of the FTO rs9939609 SNP in the study group did not reveal significant differences. An analysis of the frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP revealed that in men and women the G allele and the homozygous GG genotype prevailed. The results of the analysis of the frequency distribution of alleles and genotypes of the TM6SF2 rs58542926 SNP showed the predominance of individuals with the C allele (89% in men and 90% in women) with statistical significance in women.	Conclusion: The further studies with a larger sample size are required to detect the features of the distribution of alleles and genotypes of the FTO rs9939609 SNP and the TM6SF2 rs58542926 SNP in that population.
Mechanism of LIN28B&nbsp;in Trophoblastic Villous Cells of Unexplained Recurrent Abortion
Authors: Huang QiaoYao , Niu YanRu , Song LiJun , Huang JinZhi , Wang Chenxi , Ma Tianzhong 
Published: March 2021

Abstract
Background: LIN28B plays an important role in early embryonic development, but its role in villous trophoblast implantation and differentiation remains unknown. To verify the role of LIN28B in trophoblastic villous tissue and cells from women with URSA(unexplained recurrent spontaneous abortion)and artificial termination of pregnancy (negative control, NC). Methods:The Lin28b gene and its protein expression level were detected with real-time quantitative PCR, Western immunoblotting analysis, and immunocytochemistry. The gene was also overexpressed in chorionic villous cell lines (HTR-8/SVneo and BeWo) to examine its effect on trophoblast function.Results: The expression of LIN28B mRNA and protein of URSA villi was lower than that in the NC group. At the cellular level, overexpression of LIN28B enhanced cellular migration, and invasion, and inhibited apoptosis. LIN28B may inhibit apoptosis by promoting Akt phosphorylation and by inhibiting Bad phosphorylation and Bcl-2 expression. In addition, LIN28B inhibited cell fusion and reduced cellular syncytia. Conclusions: LIN28B can inhibit cell proliferation, invasion and migration in vitro, and promote apoptosis and fusion. The low expression of LIN28B in URSA villous trophoblast cells may be one of the causes of abortion. The role of LIN28B in villous trophoblasts needs further study.
Relating 27-day Averages of Solar, Interplanetary Medium Parameters and Geomagnetic Activity Proxies in Solar Cycle 24
Authors: Castillo Yvelice Soraya , Pais Maria Alexandra , Fernandes João , Ribeiro Paulo , Morozova Anna L. , Pinheiro Fernando J. G. 
Published: March 2021

Abstract
Correlations between solar, interplanetary medium parameters and geomagnetic activity proxies in 27-day averages (a Bartels’ rotation) were analysed for the 2009-2016 time interval. In this analysis, two new proxies were considered: 1) B ZS GSM, calculated as the daily percentage of the IMF southward component along the GSM Z-axis and then averaged every 27 days; 2) four magnetospheric indices (T-indices), calculated from the local North-South (X) contributions of the magnetosphere's cross-tail (TAIL), the symmetric ring current (SRC), the partial ring current (PRC) and the Birkeland current (FAC), derived from Tsyganenko and Sitnov 2005 (TS05) semi-empirical magnetospheric model. Our results suggest that, among the parameters tested in this study, solar facular areas, interplanetary magnetic field intensity and new proxies derived from TS05 model could be taken into account in an empirical model, with a 27-day resolution, to explain geomagnetic activity felt on the Earth's surface in terms of solar surface features and the IMF condition. We further retrieve a clear annual oscillation in series of 27-day-mean values of toward/away asymmetries of geomagnetic activity indices, which can be interpreted in the light of Russell-McPherron hypothesis for the semiannual variation of geomagnetic activity.