bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Flow Rate Escalation for Pediatric Patients on High Flow Nasal Cannula Using Machine Learning
Authors: Krachman Joshua A. , Patricoski Jessica A. , Le Christopher T. , Park Jina , Zhang Ruijing , Gong Kirby D. , Gangan Indranuj , Winslow Raimond L. , Greenstein Joseph L. , Fackler James , Sochet Anthony A. , Bergmann Jules P. 
Published: November 2021

Background: High flow nasal cannula (HFNC) is commonly used as non-invasive respiratory support in critically ill children. There are limited data to inform consensus on optimal device parameters, determinants of successful patient response, and indications for escalation of support. Clinical scores, such as the respiratory rate-oxygenation (ROX) index, have been described as a means to predict HFNC non-response, but are limited to evaluating for escalations to invasive mechanical ventilation (MV). In the presence of apparent HFNC non-response, a clinician may choose to increase the HFNC flow rate to hypothetically prevent further respiratory deterioration, transition to an alternative non-invasive interface, or intubation for MV. To date, no models have been assessed to predict subsequent escalations of HFNC flow rates after HFNC initiation.Objective: To evaluate the abilities of tree-based machine learning algorithms to predict HFNC flow rate escalations.Methods: We performed a retrospective, cohort study assessing children admitted for acute respiratory failure under 24 months of age placed on HFNC in the Johns Hopkins Children's Center pediatric intensive care unit from January 2019 through January 2020. We excluded encounters with gaps in recorded clinical data, encounters in which MV treatment occurred prior to HFNC, and cases electively intubated in the operating room. The primary study outcome was discriminatory capacity of generated machine learning algorithms to predict HFNC flow rate escalations as compared to each other and ROX indices using area under the receiver operating characteristic (AUROC) analyses. In an exploratory fashion, model feature importance rankings were assessed by comparing Shapley values.Results: Our gradient boosting model with a time window of 8 h and lead time of 1 h before HFNC flow rate escalation achieved an AUROC with a 95% confidence interval of 0.810 ± 0.003. In comparison, the ROX index achieved an AUROC of 0.525 ± 0.000.Conclusion: In this single-center, retrospective cohort study assessing children under 24 months of age receiving HFNC for acute respiratory failure, tree-based machine learning models outperformed the ROX index in predicting subsequent flow rate escalations. Further validation studies are needed to ensure generalizability for bedside application.
Post-traumatic Stress Symptoms in Adolescents Exposed to the Earthquake in Lombok, Indonesia: Prevalence and Association With Maladaptive Trauma-Related Cognition and Resilience
Authors: Wahab Suzaily , Yong Li Ling , Chieng Wei Keong , Yamil Myristica , Sawal Noor Azah , Abdullah Nurul Qiyaam , Muhdisin Noor Cyntiya Rahmawati , Wd Wiredarma Siti Mardiyah , Ismail Rosnah , Othman Aisya Hanim , Damanhuri Hanafi Ahmad 
Published: November 2021

Background: Natural disasters may physically and psychologically affect individuals and their surrounding community. This study determines the prevalence of post-traumatic stress (PTS) symptoms and its association with maladaptive trauma-related cognition and resilience among adolescents post-earthquake.Materials and Methods: Data were collected, in this cross-sectional study, during an intervention program post-earthquake held in a state high school located at Lombok, Indonesia. The study sample engaged students 14–19 years of age using the purposive sampling method. The questionnaires used to measure PTS symptoms, maladaptive trauma-related cognition, and resilience were Children's Revised Impact of Event Scale-13 (CRIES-13), Child Post-Traumatic Cognitions Inventory (CPTCI), and Child and Youth Resilience Measure-Revised (CYRM-R), respectively.Results: The prevalence of PTS symptoms was 69.9%. Among the respondents, 61.37% were female and 56.48% had mothers with lower educational levels. Using multiple linear regression, the final predictors of PTS symptoms were excessive reactions (e.g., wailing loudly, miserable shrieking) of proxy during earthquake (β = 3.283, p = 0.005), maladaptive trauma-related cognition (β = 0.224, p = 0.002), and resilience (β = 0.192, p &lt; 0.001) with female gender (β = 7.350, p &lt; 0.001) as a control variable. Through simple linear regression, victims who witnessed injury or death during the earthquake (p = 0.003), had a proxy died during the earthquake (p = 0.01), and trapped victims or those who had difficulty escaping (p = 0.01) were identified to potentially predict the occurrence of PTS symptoms, warranting further study.Conclusion: The presence of excessive proxy reactions during the earthquake, maladaptive trauma-related cognition, and resilience in adolescents exposed to a natural disaster are worth targeting and prioritizing in future post-disaster interventions.
Endoparasite Infections of the European Hedgehog (Erinaceus europaeus) in Central Italy
Authors: Mariacher Alessia , Santini Andrea , Del Lesto Irene , Tonon Sara , Cardini Elena , Barone Antonino , Eleni Claudia , Fichi Gianluca , Perrucci Stefania 
Published: November 2021

The European hedgehog is a synanthropic mammal, widely distributed in Europe. This species usually inhabits the edges of deciduous or mixed woods, but it is also very common in private gardens and public parks. Despite its popularity and frequency of contacts both with humans and with wild and domestic animals, few studies have examined the endoparasitic fauna of the hedgehog in Italy. In the present study, endoparasites of naturally deceased hedgehogs (n = 40) from central Italy (Latium and Tuscany regions) were investigated, along with concurrent gross and histopathological lesions. The most prevalent identified endoparasites were Crenosoma striatum (45%), Capillaria erinacei (42.5%) and Brachylaemus erinacei (22.5%), in accordance with previous reports from hedgehogs in southern Italy. In few subjects, Physaloptera clausa, Acanthocephalans and Cystoisospora rastegaeivae coccidia were also identified. The infection by the lungworm C. striatum was found to be significantly associated (p < 0.01) with bronchial hyperplasia and peribronchiolitis upon histopathological examination. Awareness of the most common parasitic infections in the hedgehog and of their effects on the health of these animals is extremely important, especially in wildlife rescue centers, where European hedgehog represents the most frequently hospitalized mammal species.
OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19
Authors: Curtis Helen J , MacKenna Brian , Croker Richard , Inglesby Peter , Walker Alex J , Morley Jessica , Mehrkar Amir , Morton Caroline E , Bacon Seb , Hickman George , Bates Chris , Evans David , Ward Tom , Cockburn Jonathan , Davy Simon , Bhaskaran Krishnan , Schultze Anna , Rentsch Christopher T , Williamson Elizabeth J , Hulme William J , McDonald Helen I , Tomlinson Laurie , Mathur Rohini , Drysdale Henry , Eggo Rosalind M , Wing Kevin , Wong Angel YS , Forbes Harriet , Parry John , Hester Frank , Harper Sam , Evans Stephen JW , Douglas Ian J , Smeeth Liam , Goldacre Ben ,   (The OpenSAFELY Collaborative)
Published: November 2021

BackgroundThe COVID-19 pandemic has disrupted healthcare activity. The NHS stopped non-urgent work in March 2020, later recommending services be restored to near-normal levels before winter where possible.AimTo describe the volume and variation of coded clinical activity in general practice, taking respiratory disease and laboratory procedures as examples.Design and settingWorking on behalf of NHS England, a cohort study was conducted of 23.8 million patient records in general practice, in situ using OpenSAFELY.MethodActivity using Clinical Terms Version 3 codes and keyword searches from January 2019 to September 2020 are described.ResultsActivity recorded in general practice declined during the pandemic, but largely recovered by September. There was a large drop in coded activity for laboratory tests, with broad recovery to pre-pandemic levels by September. One exception was the international normalised ratio test, with a smaller reduction (median tests per 1000 patients in 2020: February 8.0; April 6.2; September 6.9). The pattern of recording for respiratory symptoms was less affected, following an expected seasonal pattern and classified as ‘no change’. Respiratory infections exhibited a sustained drop, not returning to pre-pandemic levels by September. Asthma reviews experienced a small drop but recovered, whereas chronic obstructive pulmonary disease reviews remained below baseline.ConclusionAn open-source software framework was delivered to describe trends and variation in clinical activity across an unprecedented scale of primary care data. The COVD-19 pandemic led to a substantial change in healthcare activity. Most laboratory tests showed substantial reduction, largely recovering to near-normal levels by September, with some important tests less affected and recording of respiratory disease codes was mixed.
Pendampingan Penyusunan Pedoman Staffing Model Untuk Meningkatkan Efisiensi Usaha Pada PT. Asuransi Bangun Askrida Bandung
Authors: Ruchiyat Endang Ruchiyat , Rahmat Rahmat , Suryanto Dadang Agus 
Published: November 2021

This community service activity was carried out in Kelurahan, Cijagra, Lengkong District, Bandung City, 40253 with the target of PT. Askrida Insurance Bandung. Based on interviews and observations, the problems faced by partners today are the amount of premium rates that are difficult to compete with similar companies, poor work governance that requires employees to work overtime every day and the slow delivery of services to customers. This program has the following objectives: 1) improving the welfare of the community through the improvement of healthy financial institutions, especially insurance 2) improving the skills and professionalism of the community 3) increasing business efficiency for partners so that they are able to compete and serve the community better.
This activity uses two approaches, namely the training and mentoring approach. The training approach includes: 1) job analysis training; 2) training on work load analysis (work load analysis); and 3) skills training for the preparation of staffing model guidelines. While the mentoring methods include: 1) assistance in conducting job analysis; 2) workload analysis assistance; 3) assistance in the preparation of staffing model guidelines. The results of this community service activity have an impact on clients to be able to organize their employees well, so as to improve business efficiency and serve the community better.
CENTRAL MACULAR THICKNESS AFTER COMBINED THERAPY OF BEVACIZUMAB INTRAVITREAL INJECTION AND TOPICAL DICLOFENAC COMPARED WITH BEVACIZUMAB INTRAVITREAL INJECTION ALONE IN DIABETIC MACULAR EDEMA
Authors: Sandra Melvina Nidya , Shabrina Yumni , Widayanti Tri Wahyu , Ekantini Retno , Supartoto Agus , Sasongko Muhammad Bayu , Haryanto Supanji 
Published: November 2021

Introduction: To evaluate whether the combination of diclofenac eye drops and bevacizumab intravitreal injection would provide additional benefits over bevacizumab alone in the treatment of naïve diabetic macular edema (DME).
Methods: A total of 43 patients were enrolled consecutively and randomized into two groups to receive combination treatment with intravitreal bevacizumab and topical diclofenac (group 1) or bevacizumab alone (group 2). Group 1 patients received single bevacizumab intravitreal injection and got self-administered diclofenac eye drop four times daily for one month. Group 2 patients received single bevacizumab intravitreal injection alone. Outcome data were obtained from patient visits at baseline and at 1 month after bevacizumab intravitreal injection. All patients underwent measurement of best corrected visual acuity (BCVA), a complete eye examination, and measurement of central macular thickness (CMT).
Result: The mean reduction in CMT in the combination group was 130.42±32.57 µm (p<0.01), while in the bevacizumab alone group the reduction was 141.38±45.27 µm (p<0.01), there is no significant difference between the two groups (p=0.866). The mean improvement of BCVA was 0.32±0.10 log Mar in the combination group and 0.26±0.12 in group 2, there is no significant difference between the two groups (p=0.691). There was no adverse ocular event in the two groups.
Conclusion: In patients with naïve DME, adding diclofenac eye drop as adjuvant of bevacizumab intravitreal injection are less likely to have a meaningful effect on reducing the central macular thickness.
Keywords: Diabetic macular edema, NSAID, diclofenac, anti-VEGF, bevacizumab, central macular thickness
ASSOCIATION BETWEEN CENTRAL RETINAL THICKNESS AND VISUAL OUTCOME POST INTRAVITREAL RANIBIZUMAB INJECTION LOADING DOSES IN EXUDATIVE AGE RELATED MACULAR DEGENERATION
Authors: Ramadhan Ferdian , Yustiarini Ima , Prakosa Ady Dwi , Widjaja Sauli Ari , Sasono Wimbo , Firmansjah Muhammad 
Published: November 2021

Introduction : Age Related Macular Degeneration (AMD) stills the leading cause of blindness in developing countries for age 50 and above, increasing along higher life expectations.Anti- VEGF is the mainstay management for exudative AMD and able to reduce the central retinal thickness (CRT) and to increase the visual outcome. The aim of this study is to correlate between CRT and visual outcome in exudative AMD post intravitreal ranibizumab injection loading doses in Soetomo general academic hospital, Surabaya
Methods : This was a retrospective, cross sectional study. Fourty two eyes who met inclusion criterias were received monthly loading doses of 0.5 mg Ranibizumab intravitreal injection for three consequtives months. Baseline visual acuity (BCVA) was measured with Snellen Chart converted to LogMAR, CRT was measured by SD-OCT. Parameters was measured before the first injection and after completed three months injections.
Result : Fourty two eyes were composed by 59.5% male and 40.5% female with higher incidence in 61-70 years old (47.6%). Mean BCVA were 0.831 before and 0.624 after injection of serial Ranibizumab. Mean CRT were 346.9 and 254.2 µm before and after injection respectively. There was significant comparison between CRT and BCVA (p=0.00) & no correlation between CRT and BCVA before and after injection of Ranibizumab loading doses (p=0.418 & p=0.275)
Conclusion : There were no correlation statistically between CRT and BCVA before and after injection of loading doses Ranibizumab intravitreal in exudative AMD. Further studies may be needed to prove the etiology of this tendencies.
SISTEM INFORMASI GEOGRAFIS PEMETAAN HASIL PRODUKSI TEBU DENGAN METODE K-MEANS DI KABUPATEN MALANG
Authors: Yunianto Muhammad Fauzan , Faisol Ahmad , Vendyansyah Nurlaily 
Published: November 2021

Data informasi mengenai perkebunan tebu yang ditampilkan oleh Dinas Tanaman Pangan dan Hortikultura dan Perkebunan kabupaten Malang pada website, masih belum menampilkan secara lengkap mengenai data perkebunan tebu. Data yang ditampilkan masih berupa data tertulis berbentuk softfile, buku atau junal, dan belum menampilkan visualisasi data kedalam bentuk pemetaan.
Sistem Informasi Geografis pemetaan hasil produksi tebu dengan metode k-means dapat menjadi solusi dari permasalahan yang diuraikan. Sistem akan menampilkan informasi mengenai data perkebunan tebu dikabupaten malang, dan juga dilengkapi pemetaan produksi tebu berdasarkan jumlah produksi pada setiap kecamatan dengan menggunakan metode K-means. Pada pengelompokan pemetaan, dibagi menjadi 3 cluster yaitu dengan jumlah produksi tinggi, sedang, dan rendah.
Hasil pengujian user menunjukan bahwa hasil uji untuk Sangat Baik sebesar 28,58%, Baik sebesar 46,42%, Cukup Baik sebesar 25% dan Kurang Baik 0%. Hasil clustering k-means pada program menunjukkan jumlah C1 (Tinggi) = 23 data, C2 (Sedang) = 55, dan C3 (Rendah) = 21 data. dan hasil pemetaan yang dibedakan dengan warna sudah sesuai, dimana untuk hasil produksi "tinggi" digunakan warna biru, produksi “sedang” warna merah, produksi “rendah” warna kuning.
IMPLEMENTASI LOGIKA FUZZY PADA SISTEM MONITORING SUHU TERNAK AYAM PETELUR BERBASIS WEB
Authors: Yohanes Oraplean Cavin , Dedy Irawan Joseph , Rudhistiar Deddy 
Published: November 2021

Monitoring suhu memiliki peranan penting pada ternak ayam petelur. Dengan adanya sistem monitoring, maka pemantauan suhu dan kelembaban dapat dipermudah baik dari segi waktu maupun dalam segi kinerja.
Sistem ini terdiri dari berberapa komponen seperti, DHT11 sebabai sensor suhu dan kelembaban, BH1750 sebagai sensor intensitas cahaya, kipas pendingin, pemanas dan menggunakan NODEMCU. Sistem ini menggunakan Logika Fuzzy untuk menentukan output dari kipas pendingin dan pemanas. Apabila sistem mengidentifikasi suhu diatas keadaan normal maka pendingin mati, dan apabila suhu dibawah keadaan normal maka pemanas akan mati.
Hasil yang diperoleh pada pengujian fungsional adalah sistem dapat berjalan dengan baik pada beberapa browser. Hasil yang diperoleh dengan melakukan beberapa uji coba pada sensor DHT11 tingkat akurasi sensor DHT11 ini sebesar 98.7174% dengan rata-rata error sebesar 1.2833%, dan dari 25 kali percobaan yang dilakukan pada logika fuzzy memiliki tingkat akurasi sebesar 100%. Hasil yang diperoleh dengan melakukan 10 kali percobaan pada sensor BH1750 memiliki tingkat sebesar 98.0652% dan rata-rata error sebesar 1.9348%.
L-PGDS Attenuates Acute Lung Injury by Prostaglandin D2 in Both Dependent and Independent Ways
Authors: Horikami Daiki , Fujii Wataru , Aritake Kosuke , Murata Takahisa 
Published: November 2021

Abstract
Lipocalin-type PG D synthase (L-PGDS) has two roles: it can be a PGD synthase, or it can be a carrier protein of hydrophobic small molecules. In this study, we investigated the dual roles of L-PGDS in acute lung injury by using L-PGDS–deficient and point-mutated mice, which lack PGD2 producibility but maintain lipocalin ability. Hydrochloride (HCl) administration (0.1 M intratracheally for 6 h) caused hemorrhage and dysfunction in the wild-type (WT) mouse lung. These symptoms were accompanied by an increase in PGD2 production. Both deficiency and point mutation of L-PGDS aggravated the HCl-induced hemorrhage and dysfunction. Although both the gene modifications decreased PGD2 production, only L-PGDS–deficient mice, but not point mutation mice, lacked protein expressions of L-PGDS in the lungs. In the WT mice, HCl administration caused pulmonary edema, indexed as an increase in lung water content and protein leakage in bronchoalveolar lavage fluid. L-PGDS deficiency and point mutation similarly aggravated edema formation. HCl administration also stimulated mucin production and bronchoalveolar lavage fluid leukocyte infiltration in the WT mouse lungs. Of interest, L-PGDS deficiency, but not point mutation, exacerbated these manifestations. Consistently, only L-PGDS deficiency increased the mRNA expression of IL-33, which stimulates mucin production in the inflamed lung. These results show that L-PGDS attenuated HCl-induced acute lung injury progresses in two different ways: L-PGDS produced PGD2, which inhibited pulmonary edema formation, whereas its lipocalin ability decreased mucin formation and inflammatory cell infiltration in the inflamed lung.
Analisis Pengaruh Dana Desa, Alokasi Dana Desa dan Pendapatan Asli Desa terhadap Jumlah Penduduk Miskin Desa di Kabupaten Tuban
Authors: Agustina Tanti Auliya , Muchtolifah Muchtolifah , Sishadiyati Sishadiyati 
Published: November 2021

This study aims to analyse the difference in the Number of rural poor people in Tuban Regency between 2019 and 2020 to examine the effect of the Village Fund, Allocation of village funds (ADD) and Village original income on the Number of rural poor people in Tuban Regency in 2019-2020. The analysis tool used is panel data regression which is testing the hypothesis with the F test, t test and Coefficient of Determination (R2) at an error rate of = 5%. The results of panel data regression analysis with the selected model is the Fixed Effect Model showing that there is a difference in the Number of rural poor people in Tuban Regency between 2019 and 2020, the variables used in the model, namely the Village Fund, Allocation of village funds (ADD) and Village original income are able to explain the variation of the variable Number of rural poor by 85% and 15% are influenced by other factors that are not included in the research variables.
Keywords: Village Fund, Allocation of village funds (ADD) and Village original income
Clinical Conditions and Risk Factors of Acinetobacter Baumannii Producing Metallo Beta-Lactamases Among Hospitalized Patients
Authors: Alhusam Sulaiman 
Published: November 2021

Purpose: The study aimed to determine the clinical conditions and risk factors associated with MBL produced by A.bumannii among hospitalized patients.
Subjects and Methods: The clinical samples were collected from inpatients and subcultured on routine culture media for growth. Identification of bacteria along with antimicrobial sensitivity testing was done by VITEK®2 compact (bioMerieux). Isolates that were resistant to Meropenem and/or Imipenem were followed to detection of MBL by using metallo-β-lactamases by imipenem EDTA combined disc test (IMP-EDTA CDT) method. Demographic and clinical data of each patient were collected in terms of the type of infection, hospital-stay, associated factors, and outcome till discharge.
Results: A number of 73(86.9%) isolates of A.baumannii were resistant to carbapenem. out of 73 carbapenem-resistant isolates, 64(87.7%) were found to be MBL positive. The patients with age more than 60 years i.e. 35.9% (23/64) were found to be more common in MBL positive isolates of A. baumannii. The difference in the distribution of MBL positive and MBL negative cases with endotracheal intubation and in Surgery during the last 30 days of incubation was found to be statistically significant. The mortality rate of patients infected by MBL positive isolates of A.baumannii was 12.5%.
Conclusion: The MBL positive strains among carbapenem-resistant isolates of A.baumannii were high. endotracheal intubation and Surgery during the last 30 days were independently associated with MBL positive cases.
Implementasi Program Baca Tulis AL-Qur’an (BTQ)
Authors: Qiptiyah Titin Mariatul , Soflianti Reni 
Published: November 2021

The teacher is a strategic factor in education, responsible for the success of the development of students with all cognitive, affective, and psychomotor potential. The teacher is responsible for the learning process at the institution where he is assigned, because the system applied by the teacher affects the quality of learning completeness. Therefore, teachers must improve their knowledge and intellect and strive to be good role models for their students. Teachers are also required to advance their students' abilities in the field of science as well as in the field of morality.
This study raises the general problem, how is the role of the teacher in the implementation of learning to read and write the Qur'an at Madrasah Aliyah Roudlotul Mutaallim Baratan, Patrang District, Jember Regency. This research uses phenomenological qualitative research.
The results of the study indicate that in general the teacher's role in the implementation of learning to read and write the Qur'an is to act as a teacher and act as a mentor, in general the results can improve the quality of students. As evidence is the result of research conducted by the author of Madrasah Aliyah Roudlotul Mutaallim Baratan, Patrang District, Jember Regency