bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remarks on a recent paper titled: “On the split common fixed point problem for strict pseudocontractive and asymptotically nonexpansive mappings in Banach spaces”
Authors: Chidume C. E. 
Published: March 2021

AbstractIn a recently published theorem on the split common fixed point problem for strict pseudocontractive and asymptotically nonexpansive mappings, Tang et al. (J. Inequal. Appl. 2015:305, 2015) studied a uniformly convex and 2-uniformly smooth real Banach space with the Opial property and best smoothness constant κ satisfying the condition $0<\kappa < \frac{1}{\sqrt{2}}$
0
<
κ
<

1

2

, as a real Banach space more general than Hilbert spaces. A well-known example of a uniformly convex and 2-uniformly smooth real Banach space with the Opial property is $E=l_{p}$
E
=

l
p

, $2\leq p<\infty $
2
≤
p
<
∞
. It is shown in this paper that, if κ is the best smoothness constant of E and satisfies the condition $0<\kappa \leq \frac{1}{\sqrt{2}}$
0
<
κ
≤

1

2

, then E is necessarily $l_{2}$

l
2

, a real Hilbert space. Furthermore, some important remarks concerning the proof of this theorem are presented.
Exploring regional variability in the short-term impact of COVID-19 on property crime in Queensland, Australia
Authors: Payne Jason L. , Morgan Anthony , Piquero Alex R. 
Published: March 2021

AbstractConfronted by rapidly growing infection rates, hospitalizations and deaths, governments around the world have introduced stringent containment measures to help reduce the spread of COVID-19. This public health response has had an unprecedented impact on people’s daily lives which, unsurprisingly, has also had widely observed implications in terms of crime and public safety. Drawing upon theories from environmental criminology, this study examines officially recorded property crime rates between March and June 2020 as reported for the state of Queensland, Australia. We use ARIMA modeling techniques to compute 6-month-ahead forecasts of property damage, shop theft, residential burglary, fraud, and motor vehicle theft rates and then compare these forecasts (and their 95% confidence intervals) with the observed data for March through to June. We conclude that, with the exception of fraud, all property offence categories declined significantly. For some offence types (shop stealing, other theft offences, and residential burglary), the decrease commenced as early as March. For other offence types, the decline was lagged and did not occur until April or May. Non-residential burglary was the only offence type to significantly increase, which it did in March, only to then decline significantly thereafter. These trends, while broadly consistent across the state’s 77 local government areas still varied in meaningful ways and we discuss possible explanations and implications.
Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus
Authors: Beyer Dominik K. E. , Mattukat Annika , Freund Nadja 
Published: March 2021

Abstract
Background
Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is increased in patients with bipolar disorder in plasma samples, imaging studies and postmortem tissue and is an indicator for an inflammatory state. We could previously show that lentiviral overexpression of D1R in the medial prefrontal cortex (mPFC) of male adult rats and its termination induces bipolar disorder-like behavior. The purpose of this study was to investigate anxiety and the role of the immune system, specifically IL-6 positive neurons in this animal model. Due to its high density of inflammatory mediator receptors and therewith sensibility to immune activation, the hippocampus was investigated.

Methods
Expression of the gene for D1R in glutamatergic neurons within the mPFC of male, adult rats was manipulated through an inducible lentiviral vector. Animals over-expressing the gene (mania-like state), after termination of the expression (depressive-like) and their respective control groups were investigated. Anxiety behavior was studied in the elevated plus maze and marble burying test. Furthermore, IL-6-positive cells were counted within several subregions of the hippocampus.

Results
D1R manipulation in the mPFC had only mild effects on anxiety behavior in the elevated plus maze. However, subjects after termination buried more marbles compared to D1R over-expressing animals and their respective control animals indicating elevated anxiety behavior. In addition, animals in the depressive-like state showed higher numbers of IL-6 positive cells reflecting an elevated pro-inflammatory state in the hippocampus, in the CA3 and dentate gyrus. Consistently, inflammatory state in the whole hippocampus and anxiety behavior correlated positively, indicating a connection between anxiety and inflammatory state of the hippocampus.

Conclusions
Behavioral and neurobiological findings support the association of manipulation of the D1R in the mPFC on anxiety and inflammation in the hippocampus. In addition, by confirming changes in the inflammatory state, the proposed animal model for bipolar disorder has been further validated.
C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation
Authors: Ozawa Tatsuya , Kaneko Syuzo , Szulzewsky Frank , Qiao Zhiwei , Takadera Mutsumi , Narita Yoshitaka , Kondo Tadashi , Holland Eric C. , Hamamoto Ryuji , Ichimura Koichi 
Published: March 2021

AbstractRecurrent C11orf95-RELA fusions (RELAFUS) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis. However, the oncogenic role of the C11orf95 has not been determined. Here, we performed ChIP-seq analyses to explore genomic regions bound by RELAFUS and H3K27ac proteins in human 293 T and mouse ependymoma cells. We then utilized published RNA-Seq data from human and mouse RELAFUS tumors and identified target genes that were directly regulated by RELAFUS in these tumors. Subsequent transcription factor motif analyses of RELAFUS target genes detected a unique GC-rich motif recognized by the C11orf95 moiety, that is present in approximately half of RELAFUS target genes. Luciferase assays confirmed that a promoter carrying this motif is sufficient to drive RELAFUS-dependent gene expression. Further, the RELAFUS target genes were found to be overlapped with Rela target genes primarily via non-canonical NF-κB binding sites. Using a series of truncation and substitution mutants of RELAFUS, we also show that the activation domain in the RELAFUS moiety is necessary for the regulation of gene expression of these RELAFUS target genes. Lastly, we performed an anti-cancer drug screening with mouse ependymoma cells and identified potential anti-ependymoma drugs that are related to the oncogenic mechanism of RELAFUS. These findings suggested that RELAFUS might induce ependymoma formation through oncogenic pathways orchestrated by both C11orf95 and RELA target genes. Thus, our study unveils a complex gene function of RELAFUS as an oncogenic transcription factor in RELAFUS positive ependymomas.
The effects of images posted to social media by orthodontists on public perception of professional credibility and willingness to become a client
Authors: Meira Thiago Martins , Prestes Jeany , Gasparello Gil Guilherme , Antelo Oscar Mario , Pithon Matheus Melo , Tanaka Orlando Motohiro 
Published: March 2021

Abstract
Background
Many patients choose health professionals using the Internet, whether through websites or social media. In orthodontics, an orthodontist’s relationship with active and potential patients can be affected by social media interactions, both as a marketing tool and as a tool for providing educational information. The purpose of the present study was to analyze the public perception of professional credibility and willingness to become a client, based on images posted by orthodontists on Instagram.

Method
This was a cross-sectional study performed using a digital self-administered questionnaire based on images from public Instagram profiles of orthodontists found using certain hashtags. The themes of the posts were analyzed through a qualitative analysis, and the results were expressed as categories. After analyzing 2445 images, 12 thematic categories emerged. A total of 446 individuals (225 laypeople, 66 dental students, and 155 dentists) evaluated the images in regard to the perception of professional credibility and willingness to become a client. One-way ANOVA and chi-square tests were applied, considering a 5% significance level.

Results
It was found that more than 95% of the participants used social media, primarily Instagram, WhatsApp, and Facebook, and the social network most used to research health services was Instagram. Statistically significant differences were found in the mean value of perceived professional credibility between the groups (p < 0.05) for the following categories: “dental traction,” “mini-implant mechanics,” “before and after treatment,” “aesthetic brackets,” “metallic brackets,” and “clear aligners.” The categories “being a teacher” and “before and after treatment” had a higher impact on the participants’ perception of credibility and willingness to become a client, unlike the “social relationship” and “family relationship” categories.

Conclusions
Some of the themes found in the orthodontists’ social media posts were found to influence the perceptions around professional credibility and willingness to become a client, although there were differences among the participants in the present study.
The Mie representation for Mercury’s magnetic field
Authors: Toepfer S. , Narita Y. , Glassmeier K. -H. , Heyner D. , Kolhey P. , Motschmann U. , Langlais B. 
Published: March 2021

AbstractThe parameterization of the magnetospheric field contribution, generated by currents flowing in the magnetosphere is of major importance for the analysis of Mercury’s internal magnetic field. Using a combination of the Gauss and the Mie representation (toroidal–poloidal decomposition) for the parameterization of the magnetic field enables the analysis of magnetic field data measured in current carrying regions in the vicinity of Mercury. In view of the BepiColombo mission, the magnetic field resulting from the plasma interaction of Mercury with the solar wind is simulated with a hybrid simulation code and the internal Gauss coefficients for the dipole, quadrupole and octupole field are reconstructed from the data, evaluated along the prospective trajectories of the Mercury Planetary Orbiter (MPO) using Capon’s method. Especially, it turns out that a high-precision determination of Mercury’s octupole field is expectable from the future analysis of the magnetic field data measured by the magnetometer on board MPO. Furthermore, magnetic field data of the MESSENGER mission are analyzed and the reconstructed internal Gauss coefficients are in reasonable agreement with the results from more conventional methods such as the least-square fit.
Purchasing policy, quarantine and acclimation practices of breeding gilts in Belgian pig farms
Authors: Bernaerdt Elise , Dewulf Jeroen , Verhulst Robin , Bonckaert Caroline , Maes Dominiek 
Published: March 2021

AbstractBackgroundThe breeding population is very important in pig herds, for productivity, health and profitability. Replacement of breeding animals can be accomplished by own rearing of breeding gilts or by purchasing them. Purchasing breeding gilts is a hazardous event in terms of biosecurity and introduction of pathogens into a farm. However, in literature, little is known about gilt introduction in a herd. The present study investigated the introduction procedures of purchased breeding gilts in Belgian pig herds, and the compliance of these herds to the optimal introduction procedures. A questionnaire consisting of twenty questions related to farm characteristics (n = 2), purchasing policy (n = 6), quarantine period (n = 5), and acclimation practices (n = 7) was designed, and 68 farms completed the questionnaire during an on-farm interview.ResultsThe median (min. – max.) number of sows on the farms was 300 (85–2500). Fifty-seven per cent of the farms purchased breeding gilts, and there was a lot of variation in the frequency of purchase and the age at which gilts are purchased. On 95 % of those farms, a quarantine unit was used, and on most of these farms the quarantine was located on the farm itself (internal quarantine). The median (min. – max.) duration of the quarantine period was 42 (14–140) days. The most common acclimation practice was vaccination against Porcine parvovirus (96 %) andErysipelothrix rhusiopathiae(94 %), although in some farms exposure of gilts to farm-specific micro-organisms was done by providing faeces from suckling piglets (18 %) and bringing gilts in contact with sows that will be culled (16 %). Only 10 % of the farms complied with the optimal introduction procedures, i.e. purchasing policy, quarantine building and quarantine management.ConclusionsThis study showed that in many farms, practices related to purchasing, quarantine and acclimation could be improved to maintain optimal biosecurity.
Medical Complications and Prognostic Factors for Medically Unstable Conditions During Acute Inpatient Cancer Rehabilitation
Authors: Tennison Jegy M. , Fricke Brian C. , Fu Jack B. , Patel Tejal A. , Chen Minxing , Bruera Eduardo 
Published: March 2021

PURPOSE: Acute inpatient rehabilitation provides concurrent medical care and intensive rehabilitation. We sought to describe the nature of types of medical complications and to identify the more frequent types of medical complications management in patients with cancer undergoing acute inpatient rehabilitation. METHODS: We reviewed the records of all consecutive patients admitted to acute inpatient rehabilitation from September 1, 2017, through February 28, 2018. Presenting problem noted to be a significant change in medical status using the Centers for Medicare & Medicaid Services' Evaluation and Management Service Guide was defined as a medical complication. We recorded demographic and clinical characteristics. Multivariable logistic regression analysis was performed to assess prognostic factors for returning to acute care. RESULTS: Among 165 evaluable patients, 158 (96%) had at least one medical complication, and 31 (19%) had an unplanned return to acute care. After excluding three patients who had planned return to acute care, there was a cohort of 162 patients and the most common medical complication categories were electrolyte abnormalities 81 (50%), musculoskeletal 70 (43%), genitourinary or renal 61 (38%), hematologic 58 (36%), and cardiovascular problems 46 (28%). Multivariable analysis showed that tachycardia (odds ratio [OR], 7.83; 95% CI, 2.23 to 27.54; P = .001) and weekly or more frequent RBC transfusions (OR, 5.23; 95% CI, 1.39 to 19.64; P = .014) were independently associated with unplanned return to acute care. CONCLUSION: A high frequency and wide range of medical complications and interventions occur in patients with cancer undergoing acute inpatient rehabilitation. Close monitoring and expertise are needed for this patient population.
Opportunities Beyond the Anesthesiology Department: Broader Impact Through Broader Thinking
Authors: Mathis Michael R. , Schonberger Robert B. , Whitlock Elizabeth L. , Vogt Keith M. , Lagorio John E. , Jones Keith A. , Conroy Joanne M. , Kheterpal Sachin 
Published: March 2021

Ensuring a productive clinical and research workforce requires bringing together physicians and communities to improve health, by strategic targeting of initiatives with clear and significant public health relevance. Within anesthesiology, the traditional perspective of the field’s health impact has focused on providing safe and effective intraoperative care, managing critical illness, and treating acute and chronic pain. However, there are limitations to such a framework for anesthesiology’s public health impact, including the transient nature of acute care episodes such as the intraoperative period and critical illness, and a historical focus on analgesia alone—rather than the complex psychosocial milieu—for pain management. Due to the often episodic nature of anesthesiologists’ interactions with patients, it remains challenging for anesthesiologists to achieve their full potential for broad impact and leadership within increasingly integrated health systems. To unlock this potential, anesthesiologists should cultivate new clinical, research, and administrative roles within the health system—transcending traditional missions, seeking interdepartmental collaborations, and taking measures to elevate anesthesiologists as dynamic and trusted leaders.
This special article examines 3 core themes for how anesthesiologists can enhance their impact within the health care system and pursue new collaborative health missions with nonanesthesiologist clinicians, researchers, and administrative leaders. These themes include (1) reframing of traditional anesthesiologist missions toward a broader health system-wide context; (2) leveraging departmental and institutional support for professional career development; and (3) strategically prioritizing leadership attributes to enhance system-wide anesthesiologist contributions to improving overall patient health.
Prevention of Cardiac Surgery–Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial
Authors: Zarbock Alexander , Küllmar Mira , Ostermann Marlies , Lucchese Gianluca , Baig Kamran , Cennamo Armando , Rajani Ronak , McCorkell Stuart , Arndt Christian , Wulf Hinnerk , Irqsusi Marc , Monaco Fabrizio , Di Prima Ambra Licia , García Alvarez Mercedes , Italiano Stefano , Miralles Bagan Jordi , Kunst Gudrun , Nair Shrijit , L’Acqua Camilla , Hoste Eric , Vandenberghe Wim , Honore Patrick M. , Kellum John A. , Forni Lui G. , Grieshaber Philippe , Massoth Christina , Weiss Raphael , Gerss Joachim , Wempe Carola , Meersch Melanie 
Published: March 2021

BACKGROUND:
Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced the development of acute kidney injury (AKI) after surgery. We sought to evaluate the feasibility of implementing a bundle of supportive measures based on the KDIGO guideline in high-risk patients undergoing cardiac surgery in a multicenter setting in preparation for a large definitive trial.

METHODS:
In this multicenter, multinational, randomized controlled trial, we examined the adherence to the KDIGO bundle consisting of optimization of volume status and hemodynamics, functional hemodynamic monitoring, avoidance of nephrotoxic drugs, and prevention of hyperglycemia in high-risk patients identified by the urinary biomarkers tissue inhibitor of metalloproteinases-2 [TIMP-2] and insulin growth factor–binding protein 7 [IGFBP7] after cardiac surgery. The primary end point was the adherence to the bundle protocol and was evaluated by the percentage of compliant patients with a 95% confidence interval (CI) according to Clopper-Pearson. Secondary end points included the development and severity of AKI.

RESULTS:
In total, 278 patients were included in the final analysis. In the intervention group, 65.4% of patients received the complete bundle as compared to 4.2% in the control group (absolute risk reduction [ARR] 61.2 [95% CI, 52.6-69.9]; P < .001). AKI rates were statistically not different in both groups (46.3% intervention versus 41.5% control group; ARR −4.8% [95% CI, −16.4 to 6.9]; P = .423). However, the occurrence of moderate and severe AKI was significantly lower in the intervention group as compared to the control group (14.0% vs 23.9%; ARR 10.0% [95% CI, 0.9-19.1]; P = .034). There were no significant effects on other specified secondary outcomes.

CONCLUSIONS:
Implementation of a KDIGO-derived treatment bundle is feasible in a multinational setting. Furthermore, moderate to severe AKI was significantly reduced in the intervention group.
Cowley’s Dream of a Shadow: Imitation against Experience
Authors: Mattison Andrew 
Published: March 2021

AbstractThis essay describes Abraham Cowley’s tendency, apparent throughout his work but particularly in his collected editions of 1656 and 1668, to embrace the imitation of literary models to an extent that, as he admits, can be disconcerting for readers and interfere with the literary representation of history and his own experience. Cowley’s poetic rethinking of the legacies of Homer, Pindar, the Anacreontea, Vergil, and Claudian parallels his resistance to mimetic treatment of his life and passions. This orientation toward literary history at the expense of representation, the essay argues, is rooted in a distinctive and compelling theory of interpretation, whose significance beyond Cowley’s work is revealed by the struggles of critics from the eighteenth century to the present to make sense of the relationship between life and art in his verse. These critics unwittingly demonstrate the prescience of Cowley’s depiction of reading and interpretation as potentially alienating ruptures of the connections between poems and their subject matter.
Value of MRI texture analysis for predicting new Gleason grade group
Authors: He Xiaojing , Xiong Hui , Zhang Haiping , Liu Xinjie , Zhou Jun , Guo Dajing 
Published: March 2021

Objectives:
To explore the potential value of multiparametric magnetic resonance imaging (mpMRI) texture analysis (TA) to predict new Gleason Grade Group (GGG).

Methods
Fifty-eight lesions of fifty patients who underwent mpMRI scanning, including T 2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) prior to trans-rectal ultrasound (TRUS)-guided core prostate biopsy, were retrospectively enrolled. TA parameters were obtained by the postprocessing software, and each lesion was assigned to its corresponding GGG. TA parameters derived from T2WI and DWI were statistically analyzed in detail.

Results:
Energy, inertia, and correlation derived from apparent diffusion coefficient (ADC) maps and T2WI had a statistically significant difference among the five groups. Kurtosis, energy, inertia, correlation on ADC maps and Energy, inertia on T2WI were moderately related to the GGG trend. ADC-energy and T2-energy were significant independent predictors of the GGG trend. ADC-energy, T2WI-energy, and T2WI-correlation had a statistically significant difference between GGG1 and GGG2-5. ADC-energy were significant independent predictors of the GGG1. ADC-energy, T2WI-energy, and T2WI-correlation showed satisfactory diagnostic efficiency of GGG1 (area under the curve (AUC) 84.6, 74.3, and 83.5%, respectively), and ADC-energy showed excellent sensitivity and specificity (88.9 and 95.1%, respectively).

Conclusion:
TA parameters ADC-energy and T2-energy played an important role in predicting GGG trend. Both ADC-energy and T2-correlation produced a high diagnostic power of GGG1, and ADC-energy was perfect predictors of GGG1.

Advances in knowledge:
TA parameters were innovatively used to predict new GGG trend, and the predictive factors of GGG1 were screen out.