bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frailty in Indigenous Populations: A Scoping Review
Authors: Lewis Ebony T. , Howard Leanne , Cardona Magnolia , Radford Kylie , Withall Adrienne , Howie Adam , Rockwood Kenneth , Peters Ruth 
Published: November 2021

Background: Indigenous populations experience high rates of age-related illness when compared to their non-Indigenous counterparts. Frailty is a challenging expression of aging and an important public health priority. The purpose of this review was to map what the existing literature reports around frailty in Indigenous populations and to highlight the current gaps in frailty research within the Indigenous landscape.Method: Scoping review of English language original research articles focusing on frailty within Indigenous adult populations in settler colonial countries (Australia, Canada, New Zealand and USA). Ten electronic databases and eight relevant institutional websites were searched from inception to October 2020.Results: Nine articles met our inclusion criteria, finding this population having a higher prevalence of frailty and frailty occurring at younger ages when compared to their non-Indigenous counterparts, but two did not use a formal frailty tool. Females presented with higher levels of frailty. No culturally specific frailty tool was identified, and the included articles did not assess strategies or interventions to manage or prevent frailty in Indigenous peoples.Conclusions: There was little definitive evidence of the true frailty prevalence, approaches to frailty screening and of potential points of intervention to manage or prevent the onset of frailty. Improvements in the quality of evidence are urgently needed, along with further research to determine the factors contributing to higher rates of frailty within Indigenous populations. Incorporation of Indigenous views of frailty, and instruments and programs that are led and designed by Indigenous communities, are crucial to address this public health priority.
Integrative Descriptions of Two New Mesobiotus Species (Tardigrada, Eutardigrada, Macrobiotidae) from Vietnam
Authors: Stec Daniel 
Published: November 2021

To date, 34 tardigrade taxa have been recorded from Vietnam and this includes only two macrobiotid species belonging to the genus Mesobiotus. In this paper, two additional species of this genus, one of the M. harmsworthi group and one of the M. furciger group, are reported and described as new for science (Mesobiotus imperialis sp. nov., Mesobiotus marmoreus sp. nov.). Both descriptions have an integrative character providing detailed morphological and morphometric data collected by phase contrast and scanning electron microscopy that are linked to genetic data. The latter constitute DNA sequences of molecular markers that are commonly used in tardigrade taxonomy. The genus phylogeny is also provided, elucidating the phylogenetic position of the newly discovered taxa.
GAMBARAN PENGAMBILAN KEPUTUSAN KLINIS DALAM P4K (PROGRAM PERENCANAAN PERSALINAN DAN PENCEGAHAN KOMPLIKASI) DI DAERAH PESISIR PANTAI AMAL LAMA TARAKAN
Authors: Alfianur Alfianur , Susanti Susanti , Padilah Rahmi , Purnamasari Agus 
Published: November 2021

Latar Belakang: Perencanaan persalinan dan pencegahan komplikasi juga sangat penting untuk mencegah terjadinya keterlambatan penanganan komplikasi. Pengambilan keputusan adalah bagian yang kompleks, dipengaruhi oleh faktor individu, sosial, akses, dan sistem kesehatan. Pengakuan tepat waktu dari gejala, ketersediaan keuangan, aksesibilitas fisik fasilitas kesehatan, dan persepsi kualitas pelayanan tentang pertimbangan fasilitas rujukan yang diperlukan dalam membuat keputusan untuk mencari perawatan yang lebih baik. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh/dampak pendidikan kesehatan ibu hamil dan keluarga pada pengambilan keputusan klinis P4K (Program Perencanaan Persalinan dan Pencegahan Komplikasi)Metodologi: Penelitian ini menggunakan penelitian Deskriftif tentang sikap ibu hamil dan keluarga mengenai Program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K)Hasil: Hasil analisis data Univariat terdapat bahwa 85% Responden telah menentukan tempat bersalin, 75% telah menentukan siapa yang akan menolong persalinan, 58 % mempersiapkan transportasi, 20% telah mempersiapkan donor darah, 90% telah mempersiapkan biaya. Gambaran ini menunjukkan bahwa masih terdapat pengambilan klinis dalam P4K yang rendah terutama dalam persiapan donor darah dan persiapan transportasi. Banyak faktor yang mempengaruhi sikap ibu hamil dan keluarga dalam pengambilan keputusan klinis P4KKata Kunci: P4K, Ibu Hamil
PENGETAHUAN TENTANG COVID 19 MAHASISWA KEPERAWATAN UNIVERSITAS BORNEO TARAKAN
Authors: Alfianur Alfianur 
Published: November 2021

Latar Belakang: Covid 19 merupakan penyakit infeksi saluran pernapasan yang disebabkan oleh corona virus, penyakit ini telah menjadi pandemik, mudahnya penularan penyakit ini menyebabkan hampir semua Negara di dunia mengalami wabah ini. Pencegahan penyakit corona visrus ini telah banyak disampaikan oleh WHO dan pemrintah seperti, mencuci tangan dengan sabun pada air yang mengalir, menutup wajah dengan Masker, menjaga jarak, membatasi aktifitas dengan dirumah saja. Keberhasilan pencegahan penyakit ini yang tergantung pada kedisiplinan dan kepatuhan masyarakat melaksanakan himbauan pemerintah Tujuan dari penelitian ini adalah untuk Menganalisis hubungan tingkat pengetahuan tentang Covid 19 dengan kepatuhan dalam melakukan Pencegahan Penyakit.Metodologi: Jenis penelitian ini adalah penelitian kuantitatif dengan desain Cross sectional. Sampel penelitian ini adalah Mahasiswa Jurusan Keperawatan. Menggunakan total sampling dan pengolahan data menggunakan pendekatan statistic deskriptif (distribusi frekuensi).Hasil: Hasil analisis data didapatkan reponden memiliki tingkat pengetahuan yang Baik sebanyak 113 orang(83%) sisanya memiliki pengetahuan ditingkat Cukup sebanyak 24 orang(17%). Kata Kunci: Pengetahuan, Covid 19
The Effect Of Store Atmosphere On Purchase Decisions At Chirurgie Cafe And Books Medan
Authors: Sembiring Pramesco Wiranta 
Published: November 2021

This research is motivated by the importance of store atmosphere in a cafe or shop, because now the price, discount, promotion and service do not become guarantee of consumer to make a purchase, but store atmosphere (good store atmosphere) will be the main attraction for cafe Who own it, so as to attract consumers to make a purchase.The purpose of this research is to know the influence of store exterior, general interior, store layout and interior display to purchase decision at Chirurgie Cafe and Books Medan.This research uses quantitative method with associative approach. The population in this study were all visitors of Chirurgie Cafe and Books Medan with sample size 100 people. The sampling technique in this research is done by using Non Probability Sampling technique with accidental sampling technique and purposive sampling. Analytical methods used are validity test, reliability test, t-test, f-test, classical assumption test, multiple linear regression analysis test, and coefficient of determination (R2) test.The result of this research shows that partially the result of store exterior variables is tcount (1,728)> ttable (1,6608) and probability value 0,087 <0,1, which means that store exterior (X1) has positive and significant effect to purchasing decisions). The general interior variables show that tcount (2.234)> ttable (1.6608) and probability value 0.028 <0.1, which means that general interior (X2) has positive and significant effect to purchase decision (Y). The store layout variable shows that tcount (2.2072)> ttable (1.6608) and probability value 0.041 <0.1, which means that store layout (X3) has positive and significant effect on purchase decision (Y). Exterior store variables show that tcount (0.397)> ttable (1.6608) and probability value 0.692 <0.1, which means that interior display (X4) has positive but not significant effect on purchasing decision (Y). Simultaneously the independent variable (free) shows that the fcount is 7.011 with the significance level 0.000, while the ftable at the 90% confidence level (α = 0.10) is 2.00. Then fcount (7.011)> ftable (2.00) and probability value 0.000
<0.10, which means all independent variables simultaneously affect the dependent variable.
Indígenas urbanos e identidade: uma colaboração artística com os Wapichana
Authors: Ferreira Corrêa Antenor 
Published: November 2021

Este artigo reflete sobre o conceito de identidade na perspectiva dos indígenas urbanos. Apresenta uma obra artística resultante da interação entre o autor e membros Wapichana, uma comunidade indígena brasileira. Após colaborar em manifestações, foi realizada uma intervenção artística que produziu uma videoarte. Essa obra evidenciou diferentes vozes pertencentes a uma mesma comunidade indígena, mesclando tradição, modernidade e distintas visões sobre questões semelhantes. Essa ação contribuiu para diminuir o preconceito contra os grupos indígenas e deu visibilidade a alguns de seus problemas. Essa interação participa de uma gama de intervenções artísticas que reivindicam mudanças sociais e políticas.
DIFICULDADES DE INDIVÍDUOS VEGANOS EM DESTINOS TURÍSTICOS
Authors: Lopes Mariana Da Silva , Gimenes-Minasse Maria Henriqueta 
Published: November 2021

O veganismo é uma filosofia de vida que busca evitar a exploração de animais e crueldade contra eles, seja para fins de alimentação, vestuário ou outro propósito. Tal postura gera restrições diárias para seus praticantes, que podem ser agravadas em viagens. Este artigo tem como objetivo identificar e analisar, a partir de uma pesquisa exploratória, as principais dificuldades que veganos encontram ao planejar suas viagens, considerando a alimentação, a hospedagem e os atrativos oferecidos pelo destino. A amostra foi não probabilística e os fatores delimitantes foram: ter acesso à internet, ser usuário de redes sociais e ser vegano. Foram contabilizados 170 respondentes válidos. Dentre os resultados, destacam-se: entre os respondentes, há expressiva predominância (85,88%) daqueles que adotaram o veganismo recentemente; em relação à alimentação as principais dificuldades compreendem encontrar opções veganas e estabelecimentos exclusivamente veganos; em relação aos atrativos turísticos, a maior parte dos respondentes indicaram não haver dificuldade por se recusarem a participar de atividades que envolvam exploração animal; embora uma parcela significativa (33,5%) tenha dificuldade para encontrar atrativos que não envolvam exploração animal; em relação a meios de hospedagem, 31,7% dos respondentes declararam não encontrar dificuldades, sendo que os demais apontaram dificuldades de encontrar opções alimentares (88 ocorrências). Conclui-se que, embora o veganismo compreenda qualquer forma de exploração animal para fins de alimentação, vestimenta, de higiene e beleza e de entretenimento, as dificuldades indicadas pelos respondentes correspondem principalmente ao plano alimentar.
Tactics of Surgical Treatment of Wounded with Gunshot Injuries of the Upper Limb in Modern Conditions
Authors: Strafun S.S. , Kurinnyi I.M. , Borzykh N.O. , Tsymbaliuk Ya.V. , Shypunov V.G. 
Published: November 2021

Summary. Our study aimed to optimize the tactics of surgical treatment of wounded with gunshot wounds of the upper extremity by determining the factors influencing the outcome of treatment of servicemen in modern conditions of specialized and highly specialized medical care.
Materials and Methods. Surgical treatment of 123 patients with gunshot wounds of the upper extremity who were treated at the SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine” and the National Military Medical Clinical Center “Main Military Clinical Hospital” of the Ministry of Defense of Ukraine was analyzed. The mean age of patients was (35.3±8.7). At the level III of medical care, the largest share was occupied by wound closure (28.0%) and surgeries on the skeletal system (6.7%). At the level IV of medical care, the largest share was occupied by surgical procedures for closing unhealed wounds – 28%, due to the consequences of gunshot nerve injuries – 11.5%, fractures – 10.7%, and restorative interventions on muscles – 5.5%.
Results. By calculating the odds ratio (Odds Ratio, OR), it was found that the presence of compartment syndrome reduces the probability of obtaining a positive result by 11 times (OR=11.3), and late treatment at the level IV of care reduces the effectiveness of treatment by 9 times (OR=9.1). In the group of patients with peripheral nerve damage, satisfactory results were 6.9 times less than in the group without such damage (OR=6.9); the presence of a tissue defect worsened the prognosis of treatment by almost 5 times (OR=4.7). The average time to start surgical treatment after a gunshot wound was 2.8±5.0 days at the level III and 47.2±70.4 days at the level IV. It was found that for patients admitted to the level IV facilities for up to 30 days, the percentage increase in upper extremity function was 42.6±11.8 after treatment and 28.5±10.0 at a later start of treatment.
Conclusions. The results of the study of the factors influencing the outcome of treatment prove the need for early (up to 3 weeks) admission of wounded with gunshot wounds to the level IV of medical care.
ESCREVENDO UM ARTIGO CIENTÍFICO: PASSO A PASSO
Authors: Hartmann Cassio , César Dias Lopes Gabriel , Da Silva Ferreira Vieira Fábio , V Samuel Bensson 
Published: November 2021

O presente artigo, tem como objetivo mostrar o passo a passo para elaboração de projetos de pesquisa, tipos de pesquisa e relatórios de pesquisa. Trata-se de uma pesquisa qualitativa aquela que identifica fatores relevantes de um objeto de maneiraa analisar o teor de documentos ou realidades, nesse sentido foi possível fazer um levantamento e expor nessas laudas as diversas maneiras de pesquisa partindo da premissa do senso comum e concluindo que o pesquisador precisa conhecer e seguirum caminho metodológico, uma linha de raciocínio lógico e o caminho que se pretende percorrer para alcançar os referidos objetivos. Notando, ao final do processo a importância de ressaltar claramente os materiais, métodos e técnicas empregados nodecorrer da elaboração de projetos e relatórios científicos.
EPISTIMOLOGI MANAJEMEN DI ERA KEMAJUAN ISLAM
Authors: Sujudi Nayyif , Nabil Nabil 
Published: November 2021

AbstractIn the context of Islam, science is the beginning of human substance in building world civilization. Islamic epistemology has similarities with the term science in Western epistemology. Just as science in Western epistemology is distinguished from knowledge, science in Islamic epistemology is distinguished from opinion (ra'y). Science is not arbitrary knowledge or just opinion, but knowledge that has been tested for truth. The understanding of science is actually not much different from science, only science is limited to physical or sensory fields, science goes beyond it in non-physical fields such as metaphysics. Historical metamorphosis is added to analysis and management knowledge. Muslim philosophers are used as a basic reference as the core paradigm of management based on humanity and human patterns.Â Keywords: Epistemology, Muslim Philosophers, Islamic Management Orientation
The Lunar Fossil Figure in a Cassini State
Authors: Matsuyama Isamu , Trinh Antony , Keane James T. 
Published: November 2021

Abstract
The present ellipsoidal figure of the Moon requires a deformation that is significantly larger than the hydrostatic deformation in response to the present rotational and tidal potentials. This has long been explained as due to a fossil rotational and tidal deformation from a time when the Moon was closer to Earth. Previous studies constraining the orbital parameters at the time the fossil deformation was established find that high orbit eccentricities (e ≳ 0.2) are required at this ancient time, which is difficult to reconcile with the freezing of a fossil figure owing to the expected large tidal heating. We extend previous fossil deformation studies in several ways. First, we consider the effect of removing South Pole−Aitken (SPA) contributions from the present observed deformation using a nonaxially symmetric SPA model. Second, we use the assumption of an equilibrium Cassini state as an additional constraint, which allows us to consider the fossil deformation due to nonzero obliquity self-consistently. A fossil deformation established during Cassini state 1, 2, or 4 is consistent with the SPA-corrected present deformation. However, a fossil deformation established during Cassini state 2 or 4 requires large obliquity and orbit eccentricity (ϵ ∼ 68° and e ∼ 0.65), which are difficult to reconcile with the corresponding strong tidal heating. The most likely explanation is a fossil deformation established during Cassini state 1, with a small obliquity (ϵ ∼ −0.2°) and an orbit eccentricity range that includes zero eccentricity (0 ≤ e ≲ 0.3).
RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells
Authors: Thomsen Inesa , Kunowska Natalia , de Souza Roshni , Moody Anne-Marie , Crawford Greg , Wang Yi-Fang , Khadayate Sanjay , Whilding Chad , Strid Jessica , Karimi Mohammad M , Barr Alexis R , Dillon Niall , Sabbattini Pierangela 
Published: November 2021

Abstract
RUNX1 is a transcription factor that plays key roles in hematopoietic development and in hematopoiesis and lymphopoiesis. In this article, we report that RUNX1 regulates a gene expression program in naive mouse B cells that affects the dynamics of cell cycle entry in response to stimulation of the BCR. Conditional knockout of Runx1 in mouse resting B cells resulted in accelerated entry into S-phase after BCR engagement. Our results indicate that Runx1 regulates the cyclin D2 (Ccnd2) gene, the immediate early genes Fosl2, Atf3, and Egr2, and the Notch pathway gene Rbpj in mouse B cells, reducing the rate at which transcription of these genes increases after BCR stimulation. RUNX1 interacts with the chromatin remodeler SNF-2–related CREB-binding protein activator protein (SRCAP), recruiting it to promoter and enhancer regions of the Ccnd2 gene. BCR-mediated activation triggers switching between binding of RUNX1 and its paralog RUNX3 and between SRCAP and the switch/SNF remodeling complex member BRG1. Binding of BRG1 is increased at the Ccnd2 and Rbpj promoters in the Runx1 knockout cells after BCR stimulation. We also find that RUNX1 exerts positive or negative effects on a number of genes that affect the activation response of mouse resting B cells. These include Cd22 and Bank1, which act as negative regulators of the BCR, and the IFN receptor subunit gene Ifnar1. The hyperresponsiveness of the Runx1 knockout B cells to BCR stimulation and its role in regulating genes that are associated with immune regulation suggest that RUNX1 could be involved in regulating B cell tolerance.
B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus
Authors: Barnas Jennifer L , Albrecht Jennifer , Meednu Nida , Alzamareh Diana F , Baker Cameron , McDavid Andrew , Looney R John , Anolik Jennifer H 
Published: November 2021

Abstract
Type I IFN is essential for viral clearance but also contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), via aberrant nucleic acid–sensing pathways, leading to autoantibody production. Type III IFN (IFN-λ) is now appreciated to have a nonredundant role in viral infection, but few studies have addressed the effects of IFN-λ on immune cells given the more restricted expression of its receptor primarily to the epithelium. In this study, we demonstrate that B cells display a prominent IFN gene expression profile in patients with lupus. Serum levels of IFN-λ are elevated in SLE and positively correlate with B cell subsets associated with autoimmune plasma cell development, including CD11c+T-bet+CD21− B cells. Although B cell subsets express all IFN receptors, IFNLR1 strongly correlates with the CD11c+CD21− B cell expansion, suggesting that IFN-λ may be an unappreciated driver of the SLE IFN signature and B cell abnormalities. We show that IFN-λ potentiates gene transcription in human B cells typically attributed to type I IFN as well as expansion of T-bet–expressing B cells after BCR and TLR7/8 stimulation. Further, IFN-λ promotes TLR7/8-mediated plasmablast differentiation and increased IgM production. CD11c+ B cells demonstrate IFN-λ hyperresponsive signaling compared with other B cell subsets, suggesting that IFN-λ accelerates plasma cell differentiation through this putative extrafollicular pathway. In summary, our data support type III IFN-λ as a cytokine promoting the Ab-secreting cell pool in human viral and autoimmune disease.
Hematopoietic Stem Cell Requirement for Macrophage Regeneration Is Tissue Specific
Authors: Eddins Devon J , Kosters Astrid , Waters Jeffrey , Sosa Jasmine , Phillips Megan , Yadava Koshika , Herzenberg Leonore A , Kuipers Hedwich F , Ghosn Eliver Eid Bou 
Published: November 2021

Abstract
Tissue-resident macrophages (TRMΦ) are important immune sentinels responsible for maintaining tissue and immune homeostasis within their specific niche. Recently, the origins of TRMΦ have undergone intense scrutiny, in which now most TRMΦ are thought to originate early during embryonic development independent of hematopoietic stem cells (HSCs). We previously characterized two distinct subsets of mouse peritoneal cavity macrophages (MΦ) (large and small peritoneal MΦ) whose origins and relationship to both fetal and adult long-term (LT) HSCs have not been fully investigated. In this study, we employ highly purified LT-HSC transplantation and in vivo lineage tracing to show a dual ontogeny for large and small peritoneal MΦ, in which the initial wave of peritoneal MΦ is seeded from yolk sac–derived precursors, which later require LT-HSCs for regeneration. In contrast, transplanted fetal and adult LT-HSCs are not able to regenerate brain-resident microglia. Thus, we demonstrate that LT-HSCs retain the potential to develop into TRMΦ, but their requirement is tissue specific in the peritoneum and brain.