bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
Authors: Koss Carolin K. , Wohnhaas Christian T. , Baker Jonathan R. , Tilp Cornelia , Przibilla Michèl , Lerner Carmen , Frey Silvia , Keck Martina , Williams Cara M. M. , Peter Daniel , Ramanujam Meera , Fine Jay , Gantner Florian , Thomas Matthew , Barnes Peter J. , Donnelly Louise E. , El Kasmi Karim C. 
Published: February 2021

AbstractIL-36, which belongs to the IL-1 superfamily, is increasingly linked to neutrophilic inflammation. Here, we combined in vivo and in vitro approaches using primary mouse and human cells, as well as, acute and chronic mouse models of lung inflammation to provide mechanistic insight into the intercellular signaling pathways and mechanisms through which IL-36 promotes lung inflammation. IL-36 receptor deficient mice exposed to cigarette smoke or cigarette smoke and H1N1 influenza virus had attenuated lung inflammation compared with wild-type controls. We identified neutrophils as a source of IL-36 and show that IL-36 is a key upstream amplifier of lung inflammation by promoting activation of neutrophils, macrophages and fibroblasts through cooperation with GM-CSF and the viral mimic poly(I:C). Our data implicate IL-36, independent of other IL-1 family members, as a key upstream amplifier of neutrophilic lung inflammation, providing a rationale for targeting IL-36 to improve treatment of a variety of neutrophilic lung diseases.
Association between microRNA-146a, -499a and -196a-2 SNPs and non-small cell lung cancer: a case–control study involving 2249 subjects
Authors: Qiu Hao , Xie Zhiqiang , Tang Weifeng , Liu Chao , Wang Yafeng , Gu Haiyong , Zheng Qingfeng 
Published: February 2021

Abstract
MicroRNA (miR) acts as a negative regulator of gene expression. Many literatures have suggested that miRs may be involved in the process of cell proliferation, inflammation, oxidative stress, energy metabolism and epithelial–mesenchymal transition. Thus, miRs may be implicated in the occurrence of non-small cell lung cancer (NSCLC). In the current investigation, we included 2249 subjects (1193 NSCLC patients and 1056 controls) and designed a study to identify the relationship of miR-146a rs2910164 C/G, -499a rs3746444 A/G and -196a-2 rs11614913 T/C with the risk of NSCLC. The risk factors (e.g., body mass index (BMI), sex, smoking, drinking and age) was used to adjust the odds ratios (ORs) and 95% confidence intervals (CIs). After conducting a power value assessment, we did not confirm that the miR-single nucleotide polymorphisms (SNPs) genotypic distributions were different in NSCLC cases and controls. However, the association of miR-196a-2 rs11614913 with a decreased risk of NSCLC was identified in the female subgroup (adjusted P=0.005, power = 0.809 for TC vs. TT, and adjusted P=0.004, power = 0.849 for CC/TC vs. TT). In addition, gene–gene interaction analysis showed that rs11614913 TC/3746444 AA and rs11614913 CC/rs3746444 AA could also reduce the susceptibility to NSCLC (rs11614913 TC/rs3746444 AA vs. rs11614913 TT/rs3746444 AA, P=0.001, power = 0.912 and rs11614913 CC/rs3746444 AA vs. rs11614913 TT/rs3746444 AA, P=0.003, power = 0.836). In conclusion, in overall comparisons, we did not confirm that the rs2910164, rs3746444, and rs11614913 SNPs genotypic distributions were different in NSCLC cases and controls. However, this case–control study demonstrates that miR-196a-2 rs11614913 may be a protective factor for the development of NSCLC among female patients.
Neuronal Signaling: A reflection on the Biochemical Society’s newest journal and an exciting outlook on its next steps
Authors: Sullivan Aideen M. , Stanford S. Clare 
Published: February 2021

Abstract
The inaugural Editor-in-Chief of Neuronal Signaling, Aideen M. Sullivan, reflects on the journal’s journey so far and welcomes the new Editor-in-Chief, Clare Stanford, as she shares some of the exciting initiatives and plans for its future.
Advanced squirrel algorithm‐trained neural network for efficient spectrum sensing in cognitive radio‐based air traffic control application
Authors: Eappen Geoffrey , Shankar T. , Nilavalan Rajagopal 
Published: February 2021

AbstractIn the current scenario, there is a drastic increase in air traffic. The air to ground communication plays a crucial role in the air traffic control system. There is a limited spectrum available for aircraft to establish a connection with the Air Traffic Controller (ATC). With air traffic growth, the available spectrum is getting more congested. This paper proposed an Advanced Squirrel Algorithm (ASA)‐trained neural network (NN) for efficient spectrum sensing for cognitive radio‐based air traffic control applications. ASA is a novel metaheuristic‐based training algorithm for an NN. With the proposed algorithm, it is possible to dynamically allocate the unused spectrum for air to ground communication between aircraft and ATC. The quantitative analysis of the proposed ASA‐NN‐based spectrum sensing is done by comparing it with the existing metaheuristic‐based NN training algorithms, namely, particle swarm optimization Gravitational Search Algorithm (PSOGSA), particle swarm optimization (PSO), gravitational search algorithm (GSA), and artificial bee colony (ABC). Simulation‐based evaluation shows that the proposed ASA‐NN is capable of efficiently detecting the spectrum holes with high convergence rate as compared to PSOGSA‐, PSO‐, GSA‐, and ABC‐based algorithms.
Application of grey wolf optimisation algorithm in parameter calculation of overhead transmission line system
Authors: Shaikh Muhammad Suhail , Hua Changchun , Jatoi Munsif Ali , Ansari Muhammad Mohsin , Qader Aleem Ahmed 
Published: February 2021

AbstractThe transmission line is the main component in the power system consisting of inductance, capacitance, and resistance. These parameters are important during the transmission line design. This research work applies a novel optimisation technique, grey wolf optimisation (GWO), to calculate the overhead transmission line parameter. The best optimal value is estimated with the control variables. Furthermore, the effect of different bundle conductors, that is, two, three, and four bundle conductors, radius, and spacing between the conductors on the transmission line is also analysed. GWO is a recently developed nature‐inspired meta‐heuristic algorithm. Single‐phase and three‐phase transmission line test systems have been adopted for testing purposes. The proposed algorithm is inspired by the command hierarchy and hunting system of grey wolves. The algorithm is applied to 14 benchmark optimisation functions with dimension and number of search agents. The results of the GWO algorithms are optimised and are superior as compared to previously applied algorithms. The proposed algorithm achieved the best optimal solutions for most of these functions that have been validated statistically. From the results, it is identified that the proposed algorithm is computationally efficient and performs significantly better in terms of accuracy, robustness, and convergence speed.
Characterization of a resonant capacitively coupled wireless power transfer system for communication purposes at 6 MHz
Authors: Belau Semion , Domingos Fabiano C. , Vital de Campos de Freitas Susanna , Mirzavand Rashid , Mousavi Pedram 
Published: February 2021

AbstractThis work characterizes a wireless power transmission (WPT) system operating at the 6 MHz frequency band for wireless information transfer purposes. To perform the characterization, the channel is modelled using its 2‐port network scattering parameters. Then, a long string of symbols encoded with on–off keying and modified Miller encoding is passed through the channel model at various data rates. The original data is recovered from the channel output signal using a software‐defined receiver. Bit error rate curves and eye diagrams are created for each encoding scheme and data rate. To verify the simulated results, the aforementioned data strings are transferred through the actual WPT system and output signals are post‐processed in the digital domain with the same software‐defined receiver. For comparison purposes, the performance of the WPT channel is compared to that of a conventional wireless communication channel with a flat additive white Gaussian noise model. The simulation and measurement results demonstrate that the provided WPT system can be used for data transfer with an acceptable error rate.
A novel de‐noising method based on coherence average for ultrasonic signal of partial discharge in transformer
Authors: Cheng Jiangrong , Xu Yuan , Ding Dengwei , Liu Weidong 
Published: February 2021

AbstractUltrasonic method is widely used for the detection and location of partial discharge (PD) in transformer, however, the measured ultrasonic signal is usually corrupted by noise, and sometimes is even buried by noise entirely. Therefore, the de‐noising of the measured signal is essential. Conventional de‐nosing methods, such as wavelet method and singular value decomposition (SVD) method, generally require empirical parameter selection or estimation, and the best parameters for de‐noising vary with the PD source and noise condition, which will bring some limitation to their applicability. More importantly, conventional de‐noising methods usually have poor performance for the low signal‐to‐noise‐ratio (SNR) signals. To improve this problem, the paper proposes a de‐noising method based on coherence average for the ultrasonic signal. The de‐noising performance of the proposed method is evaluated based on a comparison with conventional methods, the results indicate that the proposed method has great de‐noising effect for the ultrasonic signals, even for the low‐SNR signals. Besides, the proposed method is free from empirical parameter selection or estimation, which can make its applicability more extensive. The proposed method can offer a practical and effective solution to the de‐noising of ultrasonic signal of PD in transformer.
Comparison of the outcomes between locally advanced cervical squamous cell carcinoma and adenocarcinoma patients treated with definitive chemoradiation
Authors: Ahlawat P. , Mitra S. , Sharma M. K. , Saxena U. , Wahi I. K. , Choudhary A. K. , Tandon S. , Surkar P. 
Published: February 2021

Objective: To present comparison of survival outcomes between locally advanced adenocarcinoma and squamous cell carcinoma patients treated with definitive chemoradiation.
Methods: It is a retrospective analysis and direct comparison between adenocarcinoma and squamous cell carcinoma cervix treated from January 2011 to December 2015. Of 73 patients analyzed 61 had squamous carcinoma histology and remaining 12 had adenocarcinoma. Inclusion criteria were patients with locally advanced stage (IIA) who have completed definitive chemoradiation and were available for response evaluation at 3 months of completion of treatment. Endpoints for the study were disease response evaluation at 3 months, progression rate, median progression free survival, median recurrence free survival, median loco-regional control, median distant metastasis free survival, median overall survival.
Results: There was no significant difference between the two histology groups with respect to rate of achieving complete response (78.6 vs 75%, p = 0.718) and rate of disease progression (36% vs 50%, p = 0.517). There was no significant difference between median PFS (57.75 vs 17.74 months; p = 0.964), median RFS (NR vs 66.03 months; p = 0.876), median loco-regional control (not reached for both; p = 0.315), median DMFS (NR vs 66.03 months; p = 0.438) and median OS (NR vs 66.13 months; p = 0.884).
Conclusions: Locally advanced squamous cell carcinoma and adenocarcinoma treated with definitive chemoradiation have similar outcomes. Small sample size is the limitation of this study.
Role of complementary cytology, colposcopy and histopathology in detecting premalignant and malignant lesions of cervix
Authors: Mangla Akanksha , Sinha Renuka 
Published: February 2021

Objective: Cervical cancer is the second most common gynecologic malignancy worldwide. India alone accounts for one fifth of total number of cases worldwide. The aim of our study was to calculate sensitivity, specificity, positive predictive value, negative predictive value, false positive rate and false negative rate of complementary cytology and colposcopy with histopathology as gold standard for detection of premalignant and malignant cervical lesions.
Methods: A cross sectional study was conducted at Vardhman Mahavir Medical College and Safdarjung hospital, Delhi, India. 100 non pregnant females with complaint of post coital or irregular vaginal bleeding and those who had unhealthy cervix on visual inspection were included in study.
Results: Colposcopy exhibited a high degree of accuracy in diagnosis of high grade lesions. Overall sensitivity of cytology was 50% whereas that of colposcopy was 83.3%. Cytology had specificity of 93.4% whereas colposcopy had specificity of 89.4%. 100% of high grade and invasive cancers on colposcopy were associated with similar findings on histology. The degree of agreement between cytology and colposcopy with histology was significant (p<0.001).
Conclusion: Colposcopy is sensitive method as compared to cytology, especially in the higher grade lesions and combination of both methods appears to be of higher diagnostic importance.
The impact of tumour regression in locally advanced carcinoma cervix during external beam radiotherapy and the need for adaptive planning
Authors: Choudhary Amit Kumar 
Published: February 2021

Aim: To study the impact of tumour regression occurring during IMRT for locally advanced Carcinoma cervix and study dose distribution to target volume and OARs and hence the need for any replanning.
Methods and Materials: 40 patients undergoing IM-IGRT and weekly chemotherapy were included in the study. After 36Gy, a second planning CT-scan was done and target volume and OARs were recontoured. First plan (non-adaptive) was compared with second plan (adaptive plan) to evaluate whether it would still offer sufficient target coverage to the CTV and spare the OARs after having delivered 36Gy. Finally new plan was created based on CT-images to investigate whether creating a new treatment plan would optimize target coverage and critical organ sparing. To measure the response of the primary tumour and pathologic nodes to EBRT, the differences in the volumes of the primary GTV and nodal GTV between the pretreatment and intratreatment CT images was calculated. Second intratreatment IMRT plans was generated, using the delineations of the intratreatment CT images. The first IMRT plan (based on the first CT-scan or non adaptive plan) was compared with second IMRT plan (based on the second CT-scan or adaptive plan).
Results: 35% patients had regression in GTV in the range of 4.1% to 5%, 20% in the range of 1.1%-2%, 15% in the range of 2.1%-3% and 20% in the range of 6%-15%. There was significant mean decrease in GTV of 4.63cc (p=0.000). There was a significant decrease in CTV on repeat CT done after 36Gy by 23.31cc (p=0.000) and in PTV by 23.31cc (p=0.000). There was a statistically significant increase in CTV D98, CTV D95, CTV D50 and CTV D2 in repeat planning CT done after 36Gy. There was no significant alteration in OARs doses.
Conclusion: Despite tumour regression and increased target coverage in locally advanced carcinoma cervix after a delivery of 36Gy there was no sparing of OARs. Primary advantage of adaptive RT seems to be in greater target coverage with non-significant normal tissue sparing.
Role of interstitial brachytherpy using template (mupit) in locally advanced carcinoma cervix
Authors: Bhange Ashish , Gulia Abhishek , Punnakal Anirudh , Anand Anil Kumar , Bansal Anil Kumar , Patro Ch. Kartikeshwar , Kumawat Naveen 
Published: February 2021

Introduction: Locally advanced carcinoma cervix includes stages IIB, IIIA, IIIB and IVA. Interstitial brachytherapy has the potential to deliver adequate dose to lateral parametrium and to vagina. Hence, it is preferable in cases with distorted anatomy, extensive (lower) vaginal wall involvement, bulky residual disease post EBRT and parametrium involvement upto lateral pelvic wall.
Aim and Objective: To determine clinical outcome and complications (acute and chronic) in locally advanced carcinoma cervix, treated with interstitial brachytherapy using template (MUPIT - Martinez universal perineal interstitial template).
Materials and Methods: This study is a retrospective analysis of 37 cases of locally advanced carcinoma cervix (stage IIB-2, IIIB-30, IVA-5), treated with EBRT (dose-median 45Gy/25#) ± concurrent chemotherapy (CCT) - Inj. Cisplatin/Inj Carboplatin, followed by interstitial brachytherapy using MUPIT from December 2009 to June 2015. Initial treatment with EBRT ± CCT was followed by intertstitial brachytherapy. Under spinal anaesthesia and epidural analgesia, MUPIT application was done. Straight and divergent needles (median 26, range 19-29) were inserted to cover parametrium adequately. Needle position was verified with planning CT scan and Brachytherapy planning was done. Dose was normalized to 5 mm box surface from outermost needle with optimization of dose to OAR (Bladder, Rectum and Sigmoid colon). Prescription dose –25Gy in 5#. Treatment was delivered by Microselectron HDR using Ir192 source. Treatment fractions were delivered twice daily with min 6 Hrs. gap in-between fractions.
Results: The median duration of follow-up was 25 months. Local control was achieved in 28 patients with residual disease in 7 patients and local recurrence in 2 patients. 10 patients had acute lower GI toxicity {Grade1 (n=6), Grade 2 (n=4)}, 2 patients had acute Grade 1 bladder toxicity. 1 patient had grade 3 and 1 patient had grade 4 chronic bladder toxicity. Chronic rectal toxicity was seen in 10 patients {Grade 2 (n=4), Grade 3 (n=4), Grade 4 (n=2)}.
Conclusion: Local control was achieved in 28/37 patients (75.6%) and overall survival rate of 81.1% at median follow up of 25 months in patients with locally advanced carcinoma cervix and unfavorable prognostic factors.
Evaluation of adequacy of conventional radiotherapy fields based on bony landmarks in cervical cancer patients using contrast enhanced CT
Authors: Deepak Tuli , Gupta M. K. , Seam R. , Sharma S. , Gupta M. , Fotedar V. , Vats S. , Himthani N. , Rana A. , Kaundal R. 
Published: February 2021

Introduction: Cervical cancer is the second leading cause of cancer death in Indian women. Although, it is known that in Western women the conventional pelvic fields based on bony landmarks provided inadequate coverage for pelvic lymph nodes in cervical cancer; it remains unclear in Indian patients because of the pelvic anatomic discrepancies. In the present study, we have tried to evaluate the adequacy of conventional pelvic fields based on bony landmarks by using CECT using pelvic vessels as surrogate of lymph nodes.
Aims and Objectives: To evaluate the lymph node location in CECT pelvis using vessels as surrogate markers.(a) To compare the data, so obtained, with the usual radiotherapy field; where bony landmarks are used to define the field.(b) To evaluate the adequacy of radiation portal defined on bony landm-arks in covering pelvic lymph nodes.
Materials and Methods: This study was conducted in the Department of Radiotherapy and Oncology, Regional Cancer Centre, IGMC, Shimla in patients suffering from carcinoma of cervix. Two dimensional radiation portals were designed on conventional simulator “Acuity.” CECT pelvis was done in the same position along with same immobilization accessories used during conventional simulation. 2 mm thick slices were taken from L1 to mid femur. Using vessels as surrogates for lymph nodes and applying Taylors guidelines, adequacy of conventional GOG field was judged.
Results: Most of the parameters failed in this study, signifying inadequacy of GOG defined field in Indian population, detailed results will be discussed at the time of presentation.
Audit on early stage carcinoma cervix primarily treated with radical surgery: A tertiary cancer care centre experience
Authors: Dharmarajan Adarsh , Geetha M. 
Published: February 2021

Introduction: Clinical staging is universally accepted for ca cervix. In early stage of carcinoma cervix both radiation and radical hysterectomy given equivalent local control rates as well as survival. Poor prognostic factors following surgery would necessitate-post-operative adjuvant radiation. Selecting the patients who is unlikely to require adjuvant treatment after surgery spares them the toxicity of multiple treatment modalities, which is worse than alone.
Aim: To find out clinico-pathological correlation in early stage carcinoma cervix treated with the surgery.
Materials and Methods: It is a retrospective audit of study. All carcinoma cervix cases primarily treated with surgery.
Results: A total of 25 cases were treated in this study. The median age of patients observed with 48 years. The common symptoms and stage were vaginal discharge (i.e., 42.30%) and 1B1 (61.53%). Most of patients were treated with type III radical hysterectomy and their clinical staging was correlated with the final histo-pathological staging. A total of 11 (i.e., 42.30%) required adjuvant treatment among them 7 (63.633%), 1 (9.09%) and 3 (27.27%) patients were in 1B1 1B2 and 2A respectively. The chi-square test has been performed to compute the correlation between clinical and histo-pathological finding. It shows that significant amount of relation present between clinical and histo-pathological findings.
Comparative evaluation of concomitant chemoradiation with weekly cisplatin and gemcitabine versus weekly cisplatin in the management of locally advanced carcinoma of uterine cervix
Authors: Gupta Vikas , Chauhan Ashok Kumar , Kaur Paramjeet , Khurana Anil , Verma Yashpal , Bansal Nupur 
Published: February 2021

Aim: To evaluate feasibility of concomitant chemoradiation with weekly cisplatin and gemcitabine, and comparing the advantage of using this regimen over cisplatin alone in terms of disease control and toxicities in management of locally advanced carcinoma cervix.
Materials and Methods: The study has been conducted on fifty previously untreated, histopathologically proven FIGO stage II B - IV A patients of carcinoma cervix, attending the Department of Radiotherapy, Post Graduate Institute of Medical Sciences, Rohtak for definitive treatment by radiation therapy. The patients were divided randomly in two groups of 25 patients each. Group I received cisplatin 40 mg/m2 and gemcitabine 125 mg/m2 with concomitant external beam radiotherapy 50 Gy/25 fractions/5 weeks, followed by intracavitary high dose rate brachytherapy 7 Gy to point A, for 3 times, once in a week. Group II received concomitant chemotherapy with cisplatin 40 mg/m2 weekly alone while radiotherapy schedule were same as in group I.
Results: Total treatment duration in group I and II were 9-11 and 8-10 weeks respectively. Complete response rate in group I and II were 92% and 80%. Grade III skin and mucosal reactions was 20% in group I and none in group II. Diarrhoea was 24% in group I & 8% in group II. Grade II & III leucopenia was seen in 28% and 4% cases of group I & group II respectively. Upper gastrointestinal and renal toxicities were comparable in both arms. After six month of follow up, no evidence of disease was seen in 92% and 80% cases of group I and group II.
Conclusion: If the toxicity is managed adequately in platinum based doublet group, it may produce improvement in response. Study is ongoing.