bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE ATTITUDE OF CHEMISTRY EDUCATION STUDENTS TO SOCIO-SCIENTIFIC ISSUES (SSI) IN CHEMISTRY LEARNING
Authors: Cahyani Vika Puji , Fadly Dewiyanti , Islawati Islawati , Ahmad Fandi 
Published: January 2025

The social-scientific problem (socio-scientific Issues) is a controversial social problem that has a link to the concept or procedural of science. Learning about socio-scientific issues can promote scientific literacy by linking science to everyday life and society. This study aimed to explore and analyze students' attitudes toward Socio-scientific Issues after being given basic chemistry using the SOIE Learning model (Strengthening, Orientation, Investigation and Evaluation) in SSI's context, and Conventional models. This research conducted during one semester of a basic chemistry course in the chemistry education department in Universitas Negeri Makassar, Indonesia, with sixty-eight chemistry students. We carried data collections out using survey questionnaires and semi-structured interviews. Data analyzed using SPSS's Independent t-test programs version 22 and tested with interview data. The results showed that there was a difference in attitudes towards significant socio-scientific issues between students taught using SSI's contextualized SOIE model and conventional models. More than 70% of students taught using SSI's contextualized SOIE model showed a more positive attitude toward SSI when compared to students taught with conventional models. The results showed that the SOIE learning model in SSI's context could be used to develop a student's attitude to socio-scientific issues in chemistry learning. Through the implementation of the SOIE learning model with SSI context, expected besides improving chemical literacy, students are also more concerned about environmental issues because of the impact of scientific-social phenomena.
Identifying potential therapeutic targets for prostate cancer with mediating role in tumor immunity
Authors: Wu Zhechun , Li Sihan , Li Yuqing , Wang Zhizhi , Wang Wei 
Published: January 2025

Abstract

Background
Prostate cancer (PCa) is a leading malignancy with a rising global incidence, posing significant challenges in treatment. The immunosuppressive tumor microenvironment (TME) in CRPC is a major barrier to effective immunotherapy. Identifying therapeutic targets that modulate the immune response within TME is crucial for advancing PCa treatment.
Materials and Methods
In this study, we employed Mendelian randomization (MR) to investigate the causal relationships between gene expression of blood proteins and PCa risk. We utilized cis-eQTL data from the eQTLGen Consortium and immune cell phenotype data from the NHGRI-EBI GWAS Catalog. Our analysis included discovery and validation cohorts, totaling over 800,000 individuals. Colocalization analysis was performed to confirm the genetic associations, and mediation MR analysis was used to explore the mediating role of proteins in tumor immunity. Drug prediction and molecular docking were applied to assess the potential of identified targets as druggable candidates.
Results
Our MR analysis identified 557 proteins associated with PCa in the discovery cohort, with 86 proteins remaining significant in an independent validation cohort. Mediation analysis revealed nine proteins that mediated the impact of immune cells on PCa. Colocalization analysis confirmed the causality of five proteins, which were further supported by phenome-wide association studies (PheWAS) and protein-protein interaction (PPI) networks. Molecular docking demonstrated strong binding affinity of potential drugs to these targets.
Conclusions
This study identified five drug targets in prostate cancer that modulate the tumor immune response. These targets may expedite drug development and personalize medicine, potentially enhancing treatment efficacy and reducing side effects.
Relationship between Moderate Alcohol Consumption and All-Cause Mortality Across Different Stages of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: a cohort study
Authors: Wang Zhuotong , Hu Lingyuan , Chen Aomiao , Wu Yichuan , Wang Geningyue , Xie Xinran , He Qiuyu , Xue Yaoming , Lin Jintao , Zheng Zongji , Jia Yijie , Chen Jiaqi 
Published: January 2025

Abstract

Background
The health effects of moderate alcohol consumption remain inconclusive, both in the general population and among individuals with specific diseases. Cardiovascular-Kidney-Metabolic Syndrome (CKM) is a novel concept that involves various health conditions. This study aimed to investigate the association between moderate alcohol consumption and all-cause mortality in different stages of CKM within the UK Biobank cohort, and to validate the findings in the NHANES population.
Methods
This study included 112,207 participants from the UK Biobank cohort, stratified by different stages of CKM. Multiple covariates were incorporated in regression analyses to explore the relationship between moderate alcohol consumption and all-cause mortality. Additionally, 10,904 participants from the NHANES cohort were analysed, stratified by sex, with restricted cubic spline (RCS) curves plotted for corroboration.
Results
The Cox regression results indicated that moderate alcohol consumption had no protective effect on either males or females. In the UK Biobank, moderate alcohol consumption was significantly associated with increased all-cause mortality, whereas no significant association was found in the NHANES cohort. Among the CKM stages, moderate drinking was positively correlated with all-cause mortality in males and females in stage II and males in stage IV, while no significant associations were observed in the other stages. The RCS curves revealed a positive correlation between alcohol consumption and all-cause mortality for both genders, indicating the absence of an "optimal drinking amount," with females showing greater sensitivity to alcohol than males.
Conclusion
While previous studies have suggested potential benefits of moderate alcohol consumption for cardiovascular health and reduced all-cause mortality, our analyses across two databases revealed no evidence supporting a protective effect. Instead, a positive correlation between alcohol consumption and all-cause mortality was observed for both genders. Therefore, even moderate alcohol intake warrants caution, and efforts should be made to minimize alcohol consumption.
Trial registration
Retrospectively registered. This is a retrospective analysis using UK Biobank and NHANES data and does not involve clinical trials.
Pan-cancer analysis reveals potential of RRM2 as a prognostic and immunological biomarker in human cancer
Authors: Ma Xiaojing , Guo Zhixiang , Xia Xiaoping 
Published: January 2025

Abstract

Background Increasing evidence suggests that RRM2 plays an important role in cancer onset, development and progression. However, the biological significance of RRM2 in pan-cancer is unclear.In this study, the expression profile and prognostic significance of RRM2 were comprehensively investigated for the first time using bioinformatics techniques, as well as the relationship between RRM2 and clinicopathologic parameters and immune cell infiltration.This study is the first to conduct a pan-cancer analysis of RRM2 for aiding the diagnosis and treatment of cancer.
Methods We comprehensively studied the expression level of RRM2, patient prognosis and its relationship with clinicopathological parameters and immune cell infiltration using bioinformatics techniques.We thoroughly analyzed the function of RRM2 in cancer through the Cancer Genome Atlas (TCGA) and Genotype-Tissue expression (GTEx) databases. Multiple web softwares and platforms were used for data analysis, including HPA,Cytoscape, GEPIA2.0, UALCAN, STRING, CancerSEA and so on.
Results The results suggest that RRM2 was significantly upregulated in a variety of tumors and is associated with prognosis.Pan-cancer analysis showed that high RRM2 expression was associated with disease-free survival (DFS) and overall survival (OS) in a variety of tumors.The mRNA expression of RRM2 was related to the infiltration of various immune cells, including DC, nTreg, iTreg, Monocyte and B cells. Finally, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) were used to explore the role of RRM2 in pan-cancer.
Conclusion RRM2 is recognized as a promising target for diagnosis, treatment and prognosis prediction and is critical for DNA replication and cancer cell proliferation.
A super-assembled synergistically nanoplatform AP@ZIF-8 Pt for hepatocarcinoma therapy
Authors: Luo Zhenzhen , Wang Dunhuang , Lin Lie , Zhou Rui , Su Yuanyuan , Zhang Zongkai , Hu Jing , Dai Yaqing , Wu Jingjing , Huang Xiaoyan , Zhou Yufei , Gong Liuyun 
Published: January 2025

Abstract

Intensive cancer treatment with nanoplatform is widely exploited in the clinic, the emerging nanomedicine offers an unparalleled opportunity for encapsulating potential antitumor drugs in a nano-carrier. Apoptin (AP)，a coding protein of VP3 gene, stem from the chicken anemia virus (CAV), can be activated in malignant cells selectively and prevents the dividing cancer cells from repairing their DNA lesions, thereby forcing them to undergo apoptosis. Herein, a three-step intelligent biodegradable drug delivery nanoplatform was designed. First, a hollow ZIF-8 was synthesized, embedded with platinum nanoparticle to form ZIF-8Pt, and then loaded with AP, and lastly formed AP@ZIF-8Pt, which possess pH-responsive drug release and cancer-targeted ability. As expected, both in vitro and in vivo experiment demonstrated that AP@ZIF-8Pt performed treatment effects in hepatocarcinoma through relieving tumor-hypoxic microenvironment, inhibiting cell proliferation, and promoting cell apoptosis. Further ranscriptomic analysis showed that the specific mechanism of the AP@ZIF-8Pt was thermogenesis, signaling pathways regulating pluripotency of stem cells, ribosome, prion disease and PI3K-Akt signaling pathway. This work highlights a new strategy for liver cancer treatment and provides a reference for treating malignant tumors.
Evaluating the performance of artificial intelligence in supporting evidence synthesis: a blinded comparison between chatbots and humans
Authors: Nordmann Kim , Sauter Stefanie , Stein Mirjam , Aigner Johanna , Redlich Marie-Christin , Schaller Michael , Fischer Florian 
Published: January 2025

Abstract

Background
With the rise of large language models, the application of artificial intelligence in research is expanding, possibly accelerating specific stages of the research processes. This study aims to compare the accuracy, completeness and relevance of chatbot-generated responses against human responses in evidence synthesis as part of a scoping review.
Methods
We employed a structured, randomised and blinded survey-based research methodology to analyse and compare responses between two human researchers and four chatbots (ZenoChat, ChatGPT 3.5, ChatGPT 4.0, and ChatFlash) to questions based on a pre-coded sample of 407 articles. These questions were part of an evidence synthesis of a scoping review dealing with digitally supported interaction between healthcare workers.
Results
The analysis revealed no significant differences in judgments of correctness between answers by chatbots and those given by humans. However, chatbots’ answers were found to recognise the context of the original text better, and they provided more complete, albeit longer, responses. Human responses were less likely to add new content to the original text or include interpretation. Amongst the chatbots, ZenoChat provided the best-rated answers, followed by ChatFlash, with ChatGPT 3.5 and ChatGPT 4.0 tying for third. Correct contextualisation of the answer was positively correlated with completeness and correctness of the answer.
Conclusions
Chatbots powered by large language models may be a useful tool to accelerate qualitative evidence synthesis. Given the current speed of chatbot development and fine-tuning, the successful applications of chatbots to facilitate research will very likely continue to expand over the coming years.
GDT-IDS: Graph-based Decision Tree Intrusion Detection System for Controller Area Network
Authors: Ye Pengdong , Liang Yanhua , Bie Yutao , Qin Guihe , Song Jiaru , Wang Yingqing , Liu Wanning 
Published: January 2025

Abstract

With the rapid development of automotive technology, the security of In-Vehicle Network (IVN) has received more and more attention. The Controller Area Network (CAN), which is widely used for in-vehicle communication, faces significant security risks due to its inherent vulnerabilities. These risks can result in issues such as attacks, data leakage, and abnormal functioning of vehicle systems. Currently, the mainstream security protection approach is the Intrusion Detection System (IDS). Graph-based IDSs have been widely studied due to their ability to extract large amounts of information and achieve high detection accuracy. However, the detection accuracy of existing methods for spoofing and replay attacks remains suboptimal. To address this issue, this paper proposes a graph theory-based decision tree IDS, named GDT-IDS, tailored to the characteristics of spoofing and replay attacks. Specifically, we introduce three novel graph features—time difference, betweenness centrality, and graph density—into the detection system, which significantly enhance the detection accuracy for various types of attacks, particularly replay and spoofing. In addition, the proposed method can effectively perform multi-class classification of mixed attacks with high accuracy. Moreover, it reduces training and testing times compared to other graph theory-based methods. In conclusion, this method not only demonstrates exceptional experimental performance but also provides a novel perspective and a potential solution for traditional IDS design.
Higher-order soliton, breather, the mixed localized wave solutions for the coupled modified Korteweg-de Vries equations
Authors: Chen Yi-Xin , Wang Yufeng , Zhang Xi , Zhao YiDi 
Published: January 2025

Abstract

Under investigation in this paper is the coupled modified Korteweg-de Vries equations. Based on Lax pair and Darboux transformation, three-soliton and two-breather solutions are derived and analyzed. And the mixed localized wave solutions are constructed through the modified Darboux transformation. Especially, the interaction solutions between rogue wave and one-breather are constructed. These results in the present work could be used to understand related physical phenomena in nonlinear optics and relevant fields.
Evaluation of Cardioprotective activity of Ethanolic extract of bark of Helicteres isora Linn.
Authors: M.Laxmikanth  , Mohammad Arif 
Published: January 2025

Abstract

This study evaluates the cardioprotective activity of the ethanolic extract of the bark of *Helicteres isora* Linn. in a laboratory model. *Helicteres isora* Linn., a medicinal plant traditionally used in various cultures for its therapeutic properties, has gained attention for its potential cardiovascular benefits. The ethanolic extract was prepared using a standard protocol and subjected to phytochemical screening, which identified the presence of flavonoids, tannins, and saponins as key phytoconstituents.In vivo experiments were conducted using a rat model subjected to isoproterenol-induced myocardial infarction. The cardioprotective effect of the extract was assessed through measurements of cardiac markers, including serum levels of creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), alongside histopathological analysis of cardiac tissues.Results indicated that administration of the ethanolic extract significantly reduced the elevated levels of cardiac biomarkers compared to the control group, suggesting a protective effect against myocardial injury. Furthermore, histopathological examination revealed a marked reduction in necrosis and inflammatory cell infiltration in the cardiac tissues of the extract-treated group.The findings of this study support the cardioprotective potential of the ethanolic extract of *Helicteres isora* Linn.
A educação inclusiva e a formação de professores: Um estudo exploratório e transnacional entre o Brasil e a França
Authors: Mafezoni Andressa Caetano , Painaud Keyla Santana , Vieira Alexandro Braga 
Published: January 2025

Este artigo objetiva discutir a Educação Inclusiva e a formação de professores nos contextos brasileiro, município de Vitória, no Estado do Espírito Santo e na França, na cidade de Bordeaux, na região da Nouvelle Aquitaine. A análise se apóia numa abordagem qualitativa à partir de grupos focais, questionários e entrevistas, realizados em cada contexto e baseado numa leitura transnacional, o que permite desvelar e compreender como cada um desses países, signatários de políticas de inclusão escolar, investem na formação dos educadores em uma perspectiva de educação inclusiva. Os resultados dessa pesquisa mostram que, nos dois países, embora existam políticas voltadas para diferentes grupos sociais, a compreensão sobre a Educação Inclusiva permanece ligada à existência da Educação Especial, o que pode constituir um freio para o desenvolvimento da inclusão escolar e para a formação de professores dentro de uma perspectiva ampliada do processo de ensino e aprendizagem.
Metodologias participativas: Possibilidades para o fortalecimento teórico da gestão social
Authors: Do Carmo Gisleine , Pereira José Roberto , Rezende Vânia Aparecida 
Published: January 2025

No cotidiano das práticas organizacionais e sociais, a Gestão Social evolui e se enriquece com a contribuição de diversos saberes, que vão além dos conhecimentos técnicos acadêmicos, incluindo também as vivências e experiências comunitárias. Este estudo tem como objetivo destacar o uso de metodologias participativas como uma alternativa para fortalecer e consolidar os pressupostos teóricos da Gestão Social. Ao adotar tais metodologias, que fomentam a ação coletiva e a aprendizagem compartilhada, proporciona-se aos participantes o acesso aos processos decisórios, resultando no fortalecimento e capacitação tanto dos atores envolvidos quanto das organizações. Essas abordagens alinham-se aos princípios fundamentais da Gestão Social, os quais preconizam uma atuação ativa nas esferas públicas em prol de objetivos comuns e da emancipação dos indivíduos. Destaca-se, assim, a importância crucial da colaboração e da participação efetiva na concepção de soluções sociais sustentáveis e inclusivas. Nesse sentido, este artigo contribui para o campo da Gestão Social ao propor a utilização de metodologias participativas como ferramentas para fortalecer e consolidar seus pressupostos teóricos. A pesquisa destaca o Diagnóstico Rápido Participativo Emancipador (DRPE) como um exemplo eficaz de metodologia que se alinha aos princípios da Gestão Social, enfatizando a participação, o diálogo e a emancipação. Por meio da análise do DRPE, o artigo evidencia como a utilização de métodos participativos, que valorizam a voz e a experiência dos indivíduos, fortalece a Gestão Social e promove a autonomia cidadã, aspectos essenciais para o fortalecimento do bem comum.
Água e território: Desafios da comunidade do assentamento Serra Negra, Floresta-PE, frente aos territórios hidrossociais do projeto de transposição do Rio São Francisco
Authors: Pinto Fabíola Maria Silva Costa , Santos Jaqueline Guimarães 
Published: January 2025

O Brasil possui um quinto de toda a água que se desloca da terra para os oceanos. Contudo, a falta de acesso à água é um desafio multifacetado, afetando diversas regiões de maneiras distintas. No Nordeste brasileiro, a baixa disponibilidade hídrica é agravada por condições climáticas adversas, associada a forma historicamente que a água vem sendo gerenciada, marcada por conflitos por água e terra. É nesse território que o Projeto de Integração do rio São Francisco (PISF) foi empreendido, causando diversos efeitos socioambientais e territoriais na região. Para tanto, este artigo tem por objetivo analisar as transformações socioterritoriais no Assentamento Serra Negra, situado em Floresta/PE, além de identificar as estratégias de lutas efetivadas pela comunidade para garantir o acesso à água. Diante disso, foi realizada uma pesquisa de abordagem qualitativa, conduzida por pesquisa de campo que permitiu a aplicação de entrevista narrativa, observações diretas com registros de diário de campo e fotográficos, bem como, coleta de documentos. Os dados coletados, por sua vez, foram examinados com base na análise temática. Os resultados apontam que o território hidrossocial do Assentamento Serra Negra foi afetado, resultando em fissura territorial, além das dificuldades do acesso à água. Contudo, a organização política da comunidade possibilitou a apropriação social da água do PISF, garantindo seu acesso.
PARTISIPASI MASYARAKAT DALAM PENGELOLAAN SAMPAH DI DESA KENEP KECAMATAN BALEN KABUPATEN BOJONEGORO
Authors: Arifin Muhammad Zaenal Arifin , Suluh Wijaya I Nyoman Suluh Wijaya , Firdausiyah Nailah Firdausiyah 
Published: January 2025

Permasalahan peningkatan produksi sampah tidak dapat diselesaikan hanya mengandalkan peran pemerintah. Pelibatan masyarakat atas pengelolaan sampah ialah strategi yang harus dilakukan untuk mengurangi beban timbulan sampah. Pelibatan masyarakat sangat penting dalam pengelolaan sampah karena masyarakat merupakan sumber sampah itu sendiri. Penelitian ini untuk mengukur tingkatan keterlibatan masyarakat dalam pengelolaan sampah di Desa Kenep Kecamatan Balen Kabupaten Bojonegoro. Penelitian ini menggunakan teknik rating scale dengan tangga partisipasi Aerstien untuk mengukur tingkat partisipasi masyarakat berdasarkan perilaku masyarakat pada pengelolaan sampah di Desa Kenep. Temuan penelitian tersebut memastikan tingkat partisipasi masyarakat di Desa Kenep pada pengelolaan sampah masuk dalam tingkat partisipasi Consultation. Pada tingkatan ini masyarakat mendapatkan informasi dari pemerintah tetapi tidak semua informasi tersebut dilaksankan kerena keterbatasan sarana dan prasarana. Tingkat Consultation mengindikasikan bahwa pelibatan peran masyarakat dalam pengelolaan sampah di Desa Kenep Kecamatan Balen Kabupaten Bojonegoro masih kurang optimal. Kondisi tersebut diakibatkan pengetahuan masyarakat mengenai pengelolaan sampah belum maksimal diimplementasikan karena belum efektifnya sosialisasi pengelolaan sampah oleh pemerintah serta belum tersedianya sarana dan prasarana persampahan yang cukup. Melakukan sosialisasi, memberikan informasi tentang pengelolaan sampah melalui beberapa media serta pertemuan dengan masyarakat dan menambahkan sarana dan prasarana persampahan di harapkan akan menaikkan tingkat partisipasi masyarakat pada tingkatan yang lebih tinggi yaitu partnership bahkan bisa menjadi di tingkatan delegated power.