bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors and Primary Diseases Responsible for Acute Kidney Injury among Neonates
Authors: Luna Sharmin Akter , Akter Syma , Jesmin Tahmina , Haque Syed Saimul , Uddin Golam Muin , Roy Ranjit Ranjan 
Published: May 2021

Background: There are several risk factors and diseases related with the acute kidney injury among neonates.
Objective: The purpose of the present study was to find out the risk factors and primary disease responsible for acute kidney injury among neonates.
Methodology: This cross-sectional study was conducted in the Department of Paediatric Nephrology at Bangabandhu Sheikh Mujib University, Dhaka, Bangladesh from May 2018 to July 2019 for a period of one year. Patients with the age group of less than 1 months who were at risk of AKI, and admitted in the inpatient department of Pediatrics and allied at Bangabandhu Sheikh Mujib University, Dhaka, Bangladesh in both sexes were selected as study population. To detect AKI, serum creatinine was measured at 0 h (baseline), 48 h and 5th day respectively.
Result: A total number of 52 patients who fulfilled the inclusion criteria were enrolled in this study. Among them 10 cases were in neonatal age group. The mean age was 10.8±5.4 days with female predominance. The risk factors of AKI in neonate was only pre-renal; mostly due to hypovolemia which was 3(60.0%) cases followed by sepsis and asphyxia which were 1(20.0%) case in each. The most patients had sepsis which was 4(40.0%) cases followed by congenital heart disease which was 2(20.0%) cases; one presented with heart failure and another one had cyanotic congenital heart disease.
Conclusion: In conclusion hypovolemia, sepsis and asphyxia are the most common risk factors of acute kidney injury among the neonates.
Journal of Current and Advance Medical Research, January 2021;8(1):12-16
Serum Hemoglobin Level in Preeclampsia
Authors: Akhtar Selina , Any Umme Hafsa , Fahmi Sonia 
Published: May 2021

Background: Pre-eclampsia is the major cause of maternal and fetal mortality and morbidity. It affects approximately 5-8% of pregnant women.
Objectives: The study was undertaken to find an association between Hemoglobin and preeclampsia.
Methodology: This cross-sectional study was carried out in the Department of Physiology at Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh from July 2009 to June 2010. For this, 60 pregnant women of preeclampsia, age ranged from 18 to 39 years, more than 20th weeks of pregnancy were included in the study (group B). They were further divided into group B1 consisting of 30 mild preeclamptic women and group B2 consisting of 30 severe preeclamptic women. For comparison age and gestational period matched 30 normotensive pregnant women control (group A) were also studied. Both control (group A) and preeclamptic women were selected from Obstetric and Gynae in and out patient Department of BSMMU and Dhaka Medical College Hospital. Maternal hemoglobin concentration was measured by standard laboratory techniques.
Result: In this study, hemoglobin levels were significantly higher in study (group B) than those of control (group A). Again Hemoglobin levels were higher in group B2 than B1, but not significant (P>0.05). Hemoglobin level was positively correlated with systolic and diastolic blood pressure but it was statistically non-significant (P>0.05).
Conclusion: The study concluded that serum hemoglobin level is associated with preeclampsia.
Journal of Current and Advance Medical Research, January 2021;8(1):39-43]
Immunophenotypic Pattern and Treatment Outcome after Completion of Induction Remission in Children with Acute Lymphoblastic Leukemia
Authors: Diba Farah , Karim Md. Anwarul , Soma Shahinoor Akter , Chowdhury Indira , Mamun Showkat , Mondal Md. Nazrul Islam 
Published: May 2021

Background: Acute lymphoblastic leukemia (ALL) is presented with different immunophenotypic pattern.
Objective: The purpose of the study was to evaluate the immunophenotypic pattern of ALL and also, to recognize the frequency of different ALL subtypes and treatment outcome after induction remission therapy.
Methodology: This prospective study was conducted in the Department of Paediatric Hematology and Oncology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from June 2017 to July 2018 for a period of one year. Newly diagnosed admitted cases of ALL aged 1 to 17.9 years were included. Immunophenotyping from aspirate marrow samples were done in a special hematology laboratory. Patients were monitored during induction remission period with physical examination and required investigations.
Result: Among 87 analyzed patients, 81 patients (93.1%) were B-cell ALL and 6 patients (6.9%) were T-cell ALL. After completion of induction remission therapy 61 patients had undergone complete remission and among them B cell ALL were 56(69.1%) and T cell were 5(83.3%) (P=0.464). None of the patient had partial response or induction failure. Complication were developed in 53(60.91%) patients during induction therapy. Most common cause of death was septicemia (22/26). Death was more in patients who had total WBC count >50X109/L (p=0.017) and received regimen B (p=0.031).
Conclusion: B cell ALL was more common and most of the patients had undergone complete remission after induction remission therapy.
Journal of Current and Advance Medical Research, January 2021;8(1):59-64
Surgical Outcomes of Temporary Ileostomy Patients attended at a Tertiary Care hospital in Dhaka City
Authors: Haque Muhammad Faridul , Syeed-Ul-Alam SM , Rahman Ayesha , Khan Md. Mahfuzur Rahman , Haque Muhammad Enamul 
Published: May 2021

Background: Management of temporary ileostomy cases is very important considering the outcomes.
Objective: The purpose of the present study was to observe the surgical complications of temporary ileostomy patients.
Methodology: This prospective cohort study was conducted in the Department of Surgery at Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh over a period of six months from July, 2011 to December, 2011. All patients who had undergone temporary ileostomy after admission were selected as the study population. Patients with temporary ileostomy at any age in both male and female were included in this study. The surgical complications like prolapse, retraction, stenosis, necrosis, skin excoriation, parastomal hernia, bleeding and wound infection were recorded.

Result: A total number of 100 patients were selected for observation and management of complications of temporary ileostomy. Their ages ranging from 15 to 65 years with mean age 33.9±11.92 years. Complications were developed in majority cases of cases (52.0%). Several systemic complications were recorded like electrolytes imbalance (31%), hypoproteinaemia (14%), RTI (6%) and significant weight loss (4%). Skin excoriation was the more frequent local complication developed in 32 (32%) patients. However, 36 patients developed laparotomy wound related complication.
Conclusion: In conclusion high frequency of complications are found among the temporary ileostomy patients.
Journal of Current and Advance Medical Research, January 2021;8(1):65-69
Sintomas depressivos em pessoas que vivem com o Vírus da Imunodeficiência Humana
Authors: Santos Gilmara Salustiano , Melo Géssyca Cavalcante de , Duprat Irena Penha , Brandão Thyara Maia , Silva Yugo Torquato da 
Published: May 2021

Introdução: Os indivíduos que vivem com HIV podem ser acometidos por discriminação e medo devido ao impacto do diagnóstico de uma infecção crônica sem cura. Além disso, podem desenvolver doenças neurológicas por danos diretos a órgãos ou alterações cognitivas associadas ao vírus, sendo a depressão uma problemática que pode ser comum nesse público. Objetivo: Avaliar a presença e a intensidade de sintomas depressivos em homens e mulheres vivendo com HIV. Método: Estudo transversal de abordagem quantitativa realizado com 76 pessoas diagnosticadas com HIV e cadastrados em um ambulatório especializado de Alagoas, Brasil. Foi utilizado o Inventário de Depressão de Beck (BDI) como instrumento de coleta dos dados. Foi realizada análise de comparação entre os sexos masculino e feminino com aplicação do teste exato de Fisher e teste de Man Withney através do Software Biostat 5.3. Resultados: Os homens com a faixa etária de 20 a 39 anos apresentaram sintomas depressivos em níveis moderados a graves (50%) e 45,2% das mulheres apresentaram intensidade grave da depressão (p=0,002). As mulheres apresentaram maiores médias de escores de sintomas depressivos em relação aos homens tanto no domínio afetivo-cognitivo (p=<0,05) quanto no somático (p=<0,05). Conclusão: Mulheres apresentam maiores scores de sintomatologia depressiva nos domínios afetivo-cognitivo e somático no BDI. É importante que os profissionais da saúde compreendam e identifiquem os sintomas depressivos e sua gravidade em sua prática clínica, visto que podem se manifestar sob intensidades diferentes entre homens e mulheres.
Hábitos alimentares e de higiene no período de isolamento social durante a pandemia da Covid-19 no Brasil
Authors: Dalmolin Sandro , Erhardt Magnólia Martins , Ströher Jeferson Aloísio , Fröder Hans , Ruis Marion , Richards Neila Silvia Pereira dos Santos , Braccini Valéria Pinheiro , Jiménez Maximiliano Segundo Escalona 
Published: May 2021

Esse trabalho objetivou analisar, mediante pesquisa totalmente on-line, os hábitos alimentares e de higiene pessoal para combater o coronavírus, no período de isolamento social imposto pelo governo, durante a pandemia da Covid-19. Elaborou-se um questionário, o qual foi enviado a contatos por meio das redes sociais WhatsApp® e Messenger®, com objetivo de descobrir se os participantes estavam fazendo uso das etiquetas comportamentais recomendadas pela ANVISA para combater a Covid-19; verificar se as pessoas estavam fazendo uso da máscara facial e respeitando o distanciamento social; avaliar os impactos na rotina das pessoas, tanto na alimentação como nos serviços de alimentação que utilizavam antes do isolamento; identificar como estavam adquirindo os alimentos e quais serviços de alimentação fizeram mais falta. A pesquisa teve a participação de pessoas de todas as regiões do estado do Rio Grande do Sul, bem como de outros estados do país. Observou-se, mediante os resultados obtidos que, apesar da maciça divulgação, ainda há a necessidade de conscientização quanto ao uso da máscara. Constatou-se que a maioria dos pesquisados não apresentavam sintomas e não necessitavam de isolamento; as compras ainda continuaram sendo feitas no modo tradicional, indo ao mercado, o que pode tornar-se ponto disseminador da doença. Sugere-se que sejam intensificadas as campanhas de orientação, bem como a realização de novas pesquisas que justifiquem intensificar medidas de etiquetas sanitárias e maior conscientização coletiva.
Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis
Authors: Chen Cong , Lin Qian , Zhu Xue-Ying , Xia Junyan , Mao Tianshi , Chi Tiange , Wan Jie , Lu Jin-Jin , Li Yan , Cui Jie , Liu Jing , Cui Xiao-Yun , Zhang Jingqian , Zhou Kun , Li Dong 
Published: May 2021

Objective: Myocardial ischemia/reperfusion (I/R) injury is one of the causes of most cardiomyocyte injuries and deaths. Berberine (BBR) has been suggested a potential to exert protective effects against myocardial I/R injury. This systematic review aims to determine the intrinsic mechanisms of BBR's protective effects in myocardial I/R injury.Methods: Seven databases were searched for studies performed from inception to July 2020. Methodological quality was assessed by SYRCLE's-RoB tool.Results: Ten studies including a total of 270 animals were included in this study. The methodology quality scores of the included studies ranged from 5 to 7 points. The meta-analysis we conducted demonstrated that BBR significantly reduced myocardial infarct size and the incidence of ventricular arrhythmia, compared to control groups (P &lt; 0.00001). Cardiac function of animals in the BBR treatment group was also markedly increased (P &lt; 0.00001). The index of myocardial apoptosis and the levels of biomarkers of myocardial infarction (LDH and CK) were also decreased in the BBR treatment groups compared to the control groups (P &lt; 0.00001).Conclusions: The pre-clinical evidence, according to our study, showed that BBR is a promising therapeutic agent for myocardial I/R injury. However, this conclusion should be further investigated in clinical studies.
Cryoballoon Ablation of Atrial Fibrillation Without Demonstration of Pulmonary Vein Occlusion—The Simplify Cryo Study
Authors: Kühne Michael , Knecht Sven , Spies Florian , Aeschbacher Stefanie , Haaf Philip , Zellweger Michael , Schaer Beat , Osswald Stefan , Sticherling Christian 
Published: May 2021

Background: The demonstration of pulmonary vein (PV) occlusion is routinely performed and considered a prerequisite for successful cryoballoon (CB) ablation of atrial fibrillation (AF). The purpose of this study was to assess the feasibility and impact on procedural parameters and outcome of a standardized procedural protocol without demonstrating PV occlusion.Methods and Results: Consecutive patients undergoing CB pulmonary vein isolation (PVI) were studied. After cMRI assessment, patients treated by PVI using a novel no-contrast (NC) protocol without routine contrast injections to demonstrate PV occlusion (NC group) were compared to patients undergoing PVI with contrast injections to demonstrate PV occlusion (standard group). One hundred patients with paroxysmal or persistent AF (age 61 ± 10 years, ejection fraction 59 ± 11%, left atrial volume index 37.2 ± 2.0 mL/m2) were studied. The NC protocol was feasible in 72 of 75 patients (96%). Total procedure time and fluoroscopy time were 64.0 ± 14.1 min and 11.0 ± 4.6 min in the NC group and 92.0 ± 25.3 min and 18.0 ± 6.0 min in the standard group, respectively (all p &lt; 0.001). Dose area product was 368 ± 362 cGy*cm2 in the NC group compared to 1928 ± 1541 cGy*cm2 in the standard group (p &lt; 0.001). Forty-five of 75 patients (60%) in the NC group and 16 of 25 patients (64%) in the standard group remained in stable sinus rhythm after a single PVI and a 1-year follow-up (p = 0.815).Conclusions: Performing CB ablation without using contrast injections to demonstrate PV occlusion was feasible, resulted in reduced radiation exposure, and increased the efficiency of the procedure.
Variable Thrust Rates of the Eastern Qilianshan Mountain Front, Northeastern Margin of the Tibet Plateau and Its Implication to the Topography of the Yongchangnan Shan
Authors: Jinghao Lei , Youli Li , Zhikun Ren , Xiu Hu , Jianguo Xiong , Fei Liu , Jinrui Liu 
Published: May 2021

It is commonly assumed a thrust has a constant slip and uplifting rate along strike, however, this simplified model cannot always be consistent with field observations. The along strike slip patterns with variable offsets and rates contain plenty of information about the characteristics of the faulting behavior and its relationship with adjacent faults. The east Qilian Shan, located at the northeastern margin of the Tibetan Plateau, provides us an excellent opportunity to study the faulting behavior in a thrust-bounded range area. Besides the previously reported slip rates of the N-W trending tectonics across the region, we augmented the data by surveying the Fengle fault (FF), one of the north bounding thrusts of the Yongchangnan Shan. Another north bounding fault is the Kangningqiao Fault (KNF), east of the FF. Based on the vertical offsets and rates along the fault, we constructed the slip pattern along strike. The results show the vertical slip rate of the FF ranges from 0.7 ± 0.1 mm/a to 2.8 ± 1.3 mm/a across three surveyed sites. The slip rate decreases from the east to the west. The FF and KNF might be inferred as two segments of a single segmented thrust controlling the uplift of the Yongchangnan Shan. By comparing the uplift onsets in the study region, we discuss the northeastward propagated deformation along the northeastern margin of the Tibet plateau.
Statistical Evaluation of Different Mathematical Models for Diffusion Weighted Imaging of Prostate Cancer Xenografts in Mice
Authors: Merisaari Harri , Laakso Hanne , Liljenbäck Heidi , Virtanen Helena , Aronen Hannu J. , Minn Heikki , Poutanen Matti , Roivainen Anne , Liimatainen Timo , Jambor Ivan 
Published: May 2021

PurposeTo evaluate fitting quality and repeatability of four mathematical models for diffusion weighted imaging (DWI) during tumor progression in mouse xenograft model of prostate cancer.MethodsHuman prostate cancer cells (PC-3) were implanted subcutaneously in right hind limbs of 11 immunodeficient mice. Tumor growth was followed by weekly DWI examinations using a 7T MR scanner. Additional DWI examination was performed after repositioning following the fourth DWI examination to evaluate short term repeatability. DWI was performed using 15 and 12 b-values in the ranges of 0-500 and 0-2000 s/mm2, respectively. Corrected Akaike information criteria and F-ratio were used to evaluate fitting quality of each model (mono-exponential, stretched exponential, kurtosis, and bi-exponential).ResultsSignificant changes were observed in DWI data during the tumor growth, indicated by ADCm, ADCs, and ADCk. Similar results were obtained using low as well as high b-values. No marked changes in model preference were present between the weeks 1−4. The parameters of the mono-exponential, stretched exponential, and kurtosis models had smaller confidence interval and coefficient of repeatability values than the parameters of the bi-exponential model.ConclusionStretched exponential and kurtosis models showed better fit to DWI data than the mono-exponential model and presented with good repeatability.
Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns
Authors: Wibowo Tunjung , Nurani Neti , Hastuti Janatin , Anggraini Alifah , Susilowati Rina , Hakimi Mohammad , Julia Madarina , Van Weissenbruch Mirjam 
Published: May 2021

Background: Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life.Objectives: To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns.Subjects/Methods: A cross-sectional study was conducted in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. A total of 45 term, appropriate for gestational age (AGA) newborns were included in this study. BMC was assessed by dual-energy x-ray absorptiometry (DXA) in the first week of life. Weight (g), length (cm) and head circumference (cm) were measured at birth. Data on maternal characteristics were obtained from the maternal health records or reported by the mothers.Results: WB BMC measured in the present study (mean ± SD: 33.2 ± 9.3 g) was lower than WB BMC of similar populations in developed countries. Multiple linear regression showed that birth weight, birth length, and gestational age had a positive association with WB BMC (p = 0.048, 0.017, and &lt;0.001, respectively), while maternal cigarette exposure had a negative association with WB BMC (p = 0.012). Male infants had significantly higher of WB BMC than female (p = 0.025). These determinants contribute to 55% variability of WB BMC.Conclusions: WB BMC in Indonesian term newborns is lower than populations in developed countries. Birth weight, length, gestational age, sex, and maternal cigarette exposure during pregnancy are significantly associated with WB BMC observed in Indonesian newborns.
Traditional Chinese Medicine Reduces the Incidence of Chemotherapy-Induced Stroke: A Five-Year Nationwide Population-Based Cohort Study From Taiwan
Authors: Huang Chien-Chen , Yang Yu-Cih , MacDonald Iona , Lai Ching-Yuan , Tu Cheng-Hao , Chen Yi-Hung 
Published: May 2021

Background: Chemotherapy is suspected to be a risk factor for stroke in patients with cancer, athough the results from large-scale studies are controversial. Few strategies are available for reducing the stroke-related risks.Methods: We analyzed stroke incidence rates in Taiwan’s Longitudinal Health Insurance database 2000 (LHID2000) for patients aged ≥20 years with newly-diagnosed cancer between Jan 1, 2000 and Dec 31, 2006, who did or did not receive chemotherapy. Moreover, we compared stroke incidence rates among chemotherapy users who did or did not use traditional Chinese medicine. All study participants were followed-up for 5 years or until they had a stroke.Results: In adjusted Kaplan-Meier analysis, the incidence of stroke was higher within the first year of cancer diagnosis among chemotherapy recipients compared with those who did not receive chemotherapy (31.1 vs. 9.75; adjusted subdistribution hazard ratio [sHR] 2.21; 95% confidence interval [CI], 1.52–3.20; p &lt; 0.001). This between-group difference persisted at 4 years of follow-up (13.6 vs. 5.42; adjusted sHR 1.94; 95% CI, 1.53–2.46; p &lt; 0.001). Similarly, the 5-year incidence rate of stroke was significantly lower among chemotherapy recipients using TCM vs. non-TCM users (0.19 vs. 0.46; adjusted sHR 0.45; 95% CI, 0.26–0.79; p &lt; 0.001), as was the mortality rate (adjusted sHR 0.55; 95% CI, 0.44–0.68; p &lt; 0.001).Conclusion: These Taiwanese data suggest that chemotherapy is a risk factor for stroke and that the use of TCM can significantly mitigate this risk. TCM also appears to reduce the mortality risk associated with chemotherapy.