bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does heavy mental workload affect moral sensitivity among critical care unit nursing professionals? a cross-sectional study
Authors: Zahednezhad Hosein , shokrollahi Nasrin , Gheshlagh Reza Ghanei , Afshar Pouya Farokhnezhad 
Published: August 2021

Abstract
Background
Moral sensitivity creates the basic attitude in providing effective ethical care to patients. Heavy mental workload is a major concern of critical care nursing professionals, which could adversely affect nursing staff and patients. The present study aimed to investigate the effects of mental workload and some demographic variables on the moral sensitivity of critical care nursing professionals.

Methods
This cross-sectional, descriptive-correlational study was performed on 181 nursing professionals working in the critical care units of Shahid Rajaei Cardiovascular Medical and Research Center in Tehran, Iran. Data were collected using a demographic questionnaire, the moral sensitivity questionnaire, and the NASA-task load index to assess mental workload. Data analysis was performed in SPSS version 22 using descriptive statistics, independent t-test, Pearson’s correlation-coefficient, and regression analysis.

Results
The results of regression analysis yielded no statistical significant relationship between heavy mental workload and moral sensitivity of the critical care nursing professionals, while clinical experience had a positive, significant association with moral sensitivity.

Conclusions
Although care nursing professionals experience a heavy mental workload in critical care units, it does not decrease their moral sensitivity. In addition, experienced nurses have higher moral sensitivity and lower mental workload. Therefore, it seems that nursing managers should pay special attention to the importance of employing experienced nurses along with younger nurses.
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target
Authors: Gampala Silpa , Shah Fenil , Lu Xiaoyu , Moon Hye-ran , Babb Olivia , Umesh Ganesh Nikkitha , Sandusky George , Hulsey Emily , Armstrong Lee , Mosely Amber L. , Han Bumsoo , Ivan Mircea , Yeh Jing-Ruey Joanna , Kelley Mark R. , Zhang Chi , Fishel Melissa L. 
Published: August 2021

AbstractBackgroundPancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic efficacy. Redox factor-1 (Ref-1), a redox signaling protein, regulates the conversion of several transcription factors (TFs), including HIF-1α, STAT3 and NFκB from an oxidized to reduced state leading to enhancement of their DNA binding. In our previously published work, knockdown of Ref-1 under normoxia resulted in altered gene expression patterns on pathways including EIF2, protein kinase A, and mTOR. In this study, single cell RNA sequencing (scRNA-seq) and proteomics were used to explore the effects of Ref-1 on metabolic pathways under hypoxia.MethodsscRNA-seq comparing pancreatic cancer cells expressing less than 20% of the Ref-1 protein was analyzed using left truncated mixture Gaussian model and validated using proteomics and qRT-PCR. The identified Ref-1’s role in mitochondrial function was confirmed using mitochondrial function assays, qRT-PCR, western blotting and NADP assay. Further, the effect of Ref-1 redox function inhibition against pancreatic cancer metabolism was assayed using 3D co-culture in vitro and xenograft studies in vivo.ResultsDistinct transcriptional variation in central metabolism, cell cycle, apoptosis, immune response, and genes downstream of a series of signaling pathways and transcriptional regulatory factors were identified in Ref-1 knockdown vs Scrambled control from the scRNA-seq data. Mitochondrial DEG subsets downregulated with Ref-1 knockdown were significantly reduced following Ref-1 redox inhibition and more dramatically in combination with Devimistat in vitro. Mitochondrial function assays demonstrated that Ref-1 knockdown and Ref-1 redox signaling inhibition decreased utilization of TCA cycle substrates and slowed the growth of pancreatic cancer co-culture spheroids. In Ref-1 knockdown cells, a higher flux rate of NADP + consuming reactions was observed suggesting the less availability of NADP + and a higher level of oxidative stress in these cells. In vivo xenograft studies demonstrated that tumor reduction was potent with Ref-1 redox inhibitor similar to Devimistat.ConclusionRef-1 redox signaling inhibition conclusively alters cancer cell metabolism by causing TCA cycle dysfunction while also reducing the pancreatic tumor growth in vitro as well as in vivo.
Variability is not uncertainty; mobility is not flexibility: Clarifying concepts in pastoralism studies with evidence from Tajikistan
Authors: Gillin Kramer 
Published: August 2021

AbstractAs the “new rangeland paradigm” took shape in the 1990s, climatic variability in pastoral ecosystems was often discussed as “uncertainty”, and the essential mobility of pastoral systems was argued to be possible only with flexible land access rights. These context-specific principles have increasingly been globalized in analyses of diverse pastoral systems. While new understandings of the role of uncertainty and flexibility in pastoral systems have been unquestionably beneficial for particular contexts, uncertainty has been problematically embraced as intrinsically central to pastoral systems.This paper combines a critical review of the literature and field work in Tajikistan’s Rasht Valley to bring into clear relief differences between variability and uncertainty, on the one hand, and mobility and flexibility, on the other. This allows us to see that livestock mobility is a strategy to cope with environmental variability in all pastoral contexts. Flexibility, however, is a strategy to cope with environmental uncertainty that is only present in a subset of pastoral contexts. Importantly, flexibility is not a required precondition for mobility. These realizations carry important implications for governance in pastoral settings. Due to the many challenges of building flexibility into property systems, pastoral land governance should be developed by looking for predictability, and efforts to maintain flexibility should be judicious and empirically well-justified.
Clutter cancellation in passive radar using batch-based CLEAN technique
Authors: Bai Xia , Han Jiatong , Zhao Juan , Feng Yuan , Tao Ran 
Published: August 2021

AbstractPassive radar (PR) systems need to detect the presence of a target response, which is many orders of magnitude weaker than the clutter (direct signal and multipath). Indeed, the clutter cancellation is a key stage within a PR processing scheme. One of the most effective techniques in this field is using the CLEAN approach. In this paper, the batch-based CLEAN technique based on GMP and FFT has been proposed, which can speed up the computational processing and have better cancellation gain. Furthermore, segmenting operation can be applied to the signal obtained over long time. It is helpful to enhance temporal or spatial efficiency and overcome effect of time-varying clutter. Experiment results with simulated and real passive radar data verify the effectiveness of the proposed algorithm.
Combination of HBIM and UAV photogrammetry for modelling and documentation of forgotten heritage. Case study: Isabel II dam in Níjar (Almería, Spain)
Authors: Martínez-Carricondo Patricio , Carvajal-Ramírez Fernando , Yero-Paneque Lourdes , Agüera-Vega Francisco 
Published: August 2021

Abstract
The Isabel II dam is a monumental hydraulic structure built in the middle of the nineteenth century in Spain. In this study, unmanned aerial vehicle (UAV) photogrammetry was used as a data acquisition technique to carry out a survey of the dam’s current state and its surrounding constructions. The point cloud obtained by the photogrammetric process, together with the collected historical in-formation, served as the basis to generate an historic building information model (HBIM) that is the central core containing all the graphical, structural and archaeological information. The HBIM was validated by means of the As-Built for Autodesk Revit®-FARO® plug-in, and shows the high accuracy obtained with respect to the point cloud. The results show that with this methodology it is possible to obtain models representative of reality with an accuracy of ± 0.05 m. In addition, in order to improve the visualization, texture adjustments are made to obtain a photorealistic rendering of the model.
Microbial lipid fermentation of Trichosporon cutaneum in high saline water
Authors: Sun Luhuan , Shao Shuai , Bao Jie 
Published: August 2021

AbstractFermentative production of microbial lipid requires high fresh water input. The utilization of high saline seawater or industrial wastewater is an important alternative to reduce the freshwater consumption. This study revealed that oleaginous yeast Trichosporon cutaneum was tolerant to a high salinity up to 130 g/L of NaCl after long-term adaptive evolution. Lipid fermentation of T. cutaneum in seawater achieved the lipid production of 31.7 g/L with approximately 36% greater than that in freshwater. The saline water containing phenol was also tested for lipid fermentation and 23.6 g/L of lipid was produced simultaneously with the complete biodegradation of phenol. An interesting phenomenon was also observed that the yeast cells spontaneously segregated onto the upper surface of the saline water. This study extended the lipid fermentation options with practical application potentials.
Geoecological parameters indicate discrepancies between potential and actual forest area in the forest-steppe of Central Mongolia
Authors: Klinge Michael , Dulamsuren Choimaa , Schneider Florian , Erasmi Stefan , Bayarsaikhan Uudus , Sauer Daniela , Hauck Markus 
Published: August 2021

Abstract
Background
Forest distribution in the forest-steppe of Mongolia depends on relief, permafrost, and climate, and is highly sensitive to climate change and anthropogenic disturbance. Forest fires and logging decreased the forest area in the forest-steppe of Mongolia. The intention of this study was to identify the geoecological parameters that control forest distribution and living-tree biomass in this semi-arid environment. Based on these parameters, we aimed to delineate the area that forest might potentially occupy and to analyse the spatial patterns of actual and potential tree biomass.

Methods
We used a combination of various geographic methods in conjunction with statistical analyses to identify the key parameters controlling forest distribution. In several field campaigns, we mapped tree biomass and ecological parameters in a study area within the Tarvagatai Nuruu National Park (central Mongolia). Forest areas, topographic parameters and vegetation indices were obtained from remote sensing data. Significant correlations between forest distribution and living-tree biomass on one hand, and topographic parameters, climate data, and environmental conditions on the other hand, were used to delineate the area of potential forest distribution and to estimate total living-tree biomass for this area.

Results
Presence of forest on slopes was controlled by the factors elevation, aspect, slope, mean annual precipitation, and mean growing-season temperature. Combining these factors allowed for estimation of potential forest area but was less suitable for tree-biomass delineation. No significant differences in mean living-tree biomass existed between sites exposed to different local conditions with respect to forest fire, exploitation, and soil properties. Tree biomass was reduced at forest edges (defined as 30 m wide belt), in small fragmented and in large forest stands. Tree biomass in the study area was 20 × 109 g (1,086 km2 forest area), whereas the potential tree biomass would reach up to 65 × 109 g (> 3168 km2).

Conclusions
The obtained projection suggests that the potential forest area and tree biomass under the present climatic and geoecological conditions is three times that of the present forest area and biomass. Forest fires, which mostly affected large forest stands in the upper mountains, destroyed 43% of the forest area and 45% of the living-tree biomass in the study area over the period 1986–2017.
Fostering equitable access to quality preschool education in India: challenges and opportunities
Authors: Rao Nirmala , Ranganathan Namita , Kaur Ravneet , Mukhopadhayay Rashi 
Published: August 2021

AbstractThis paper focuses on the provision of center-based preschool education for children ranging in age from 3 to 6 years in India. It estimates access rates to various services and highlights issues related to equitable access to preschool services and the quality of preschool education. While India has made great strides in improving access to preschool education, numerous challenges have to be addressed to enhance its quality. The National Educational Policy 2020 and the country’s commitment to meet UN Sustainable Development Goal Target 4.2 by 2030 and ensure that all girls and boys have access to quality pre-primary education provide opportunities to ensure equitable access to quality preschool education. Central to meeting national targets is the enforcement of the National Quality Standards for Early Childhood Care and Education. Further, increased budget allocations to preschool education, prioritizing professional preparation of the early childhood work force and harnessing technology to monitor government programs have considerable potential to enhance the early childhood system.
Chronotype and self-reported sleep, alertness, and mental health in U.S. sailors
Authors: Harrison Elizabeth M. , Easterling Alexandra P. , Schmied Emily A. , Hurtado Suzanne L. , Glickman Gena L. 
Published: August 2021

AbstractService members are at risk for sleep and psychological conditions affecting their readiness. Chronotype (“morningness” or “eveningness”) is strongly associated with sleep, health and performance. The objective of this study was to examine associations between validated measures of chronotype and sleep quality, daytime functioning, alertness, and symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD) in US service members (n = 298). Although predominantly young males (who skew toward eveningness in civilian populations), these Sailors skewed toward morningness (35.6% morning, 51.3% intermediate). Eveningness was associated with symptoms of depression and post-traumatic stress disorder (PTSD) (P < 0.01), less time in bed (P < 0.05), more sleep disruption (P < 0.01), and poorer daytime functioning and alertness (P < 0.05). Evening types were less likely to consider sleep important for performance (P < 0.05). To maximize service member readiness, schedules should be aligned with endogenous rhythms, whenever possible, and evening chronotypes may benefit from targeted interventions. Chronotype should be examined alongside health and readiness in service members.
Hybrid membranes for the production of blood contacting surfaces: physicochemical, structural and biomechanical characterization
Authors: Todesco Martina , Zardin Carlo , Iop Laura , Palmosi Tiziana , Capaldo Pietro , Romanato Filippo , Gerosa Gino , Bagno Andrea 
Published: August 2021

Abstract

Background
Due to the shortage of organs’ donors that limits biological heart transplantations, mechanical circulatory supports can be implanted in case of refractory end-stage heart failure to replace partially (Ventricular Assist Device, VAD) or completely (Total Artificial Heart, TAH) the cardiac function. The hemocompatibility of mechanical circulatory supports is a fundamental issue that has not yet been fully matched; it mostly depends on the nature of blood-contacting surfaces.

Methods
In order to obtain hemocompatible materials, a pool of hybrid membranes was fabricated by coupling a synthetic polymer (polycarbonate urethane, commercially available in two formulations) with a decellularized biological tissue (porcine pericardium). To test their potential suitability as candidate materials for realizing the blood-contacting surfaces of a novel artificial heart, hybrid membranes have been preliminarily characterized in terms of physicochemical, structural and mechanical properties.

Results
Our results ascertained that the hybrid membranes are properly stratified, thus allowing to expose their biological side to blood and their polymeric surface to the actuation system of the intended device. From the biomechanical point of view, the hybrid membranes can withstand deformations up to more than 70 % and stresses up to around 8 MPa.

Conclusions
The hybrid membranes are suitable for the construction of the ventricular chambers of innovative mechanical circulatory support devices.
Trends in the effects of climate change on terrestrial ecosystems in the Republic of Korea
Authors: Choi Sei-Woong , Kong Woo-Seok , Hwang Ga-Young , Koo Kyung Ah 
Published: August 2021

AbstractIn this review, we aimed to synthesize the current knowledge on the observed and projected effects of climate change on the ecosystems of Korea (i.e., the Republic of Korea (ROK) or South Korea), as well as the main causes of vulnerability and options for adaptation in these ecosystems based on a range of ecological and biogeographical data. To this end, we compiled a set of peer-reviewed papers published since 2014. We found that publication of climate-related studies on plants has decreased in the field of plant phenology and physiology, whereas such publication has rapidly increased in plant and animal community ecology, reflecting the range shifts and abundance change that are occurring under climate change. Plant phenology studies showed that climate change has increased growing seasons by advancing the timing of flowering and budburst while delaying the timing of leafing out. Community ecology studies indicated that the future ranges of cold-adapted plants and animals could shrink or shift toward northern and high-elevation areas, whereas the ranges of warm-adapted organisms could expand and/or shift toward the areas that the aforementioned cold-adapted biota previously occupied. This review provides useful information and new insights that will improve understanding of climate change effects on the ecosystems of Korea. Moreover, it will serve as a reference for policy-makers seeking to establish future sectoral adaptation options for protection against climate change.
Psychometric validation of the Hypoparathyroidism Patient Experience Scales (HPES)
Authors: Brod Meryl , McLeod Lori , Markova Denka , Gianettoni Jill , Mourya Sanchita , Lin Zhengning , Shu Aimee , Smith Alden 
Published: August 2021

Abstract
Background
Hypoparathyroidism (HP) is a rare endocrine disorder characterized by absent or inappropriately low levels of circulating parathyroid hormone with associated significant physical and cognitive symptoms. This study evaluated the psychometric properties of the Hypoparathyroidism Patient Experience Scales (HPES), which were developed as disease-specific, patient-reported outcome (PRO) measures to assess the symptoms and impacts associated with HP in adults.

Methods
Data from a non-interventional, observational study (N = 300) and a Phase 2 clinical trial (N = 59) were used in the psychometric evaluation. Observational and trial assessments included: an online validation battery (baseline or screening) and retest (approximately 2 weeks after baseline or screening). In the trial, the primary efficacy endpoint was assessed at week 4 through re-administration of the HPES and validation battery subset. The observational study’s larger sample size allowed for evaluation of the HPES descriptive properties, scoring algorithm, test-retest reliability, and construct validity. The trial data examined responsiveness, meaningful within-patient change estimates, and treatment impact on HPES scores.

Results
Demographic and self-reported medical characteristics results were similar across the 2 studies. Factor analysis confirmed domains in the HPES-Symptom (n = 2) and HPES-Impact (n = 4). For both measures, total and domain scores demonstrated acceptable reliability and validity for both the observational and trial samples. Internal consistency evidence was strong. Test-retest reliability estimates generally approached the recommended 0.70 threshold. The construct validity correlations with other PRO measures were mainly as hypothesized, thus supporting the HPES scores and constructs. Mean scores for both measures also differed as anticipated and significantly across known-groups, thus providing evidence for the scores discriminating between meaningful groups. Trial results supported both HPES total and domain scores’ ability to detect change. The difference in mean total and domain scores for both measures demonstrated statistically significant improvements for TransCon PTH compared to placebo treated subjects despite the small sample and a short 4-week duration on fixed, non-optimized doses.

Conclusions
The HPES were found to be conceptually sound with adequate evidence supporting their reliability and validity. Incorporation of the HPES into clinical and research settings will help to further elucidate and assess the patient experience of living with HP and identify treatment differences.
Flavonoid compounds of buah merah (Pandanus conoideus Lamk) as a potent SARS-CoV-2 main protease inhibitor: in silico approach
Authors: Umar Abd. Kakhar 
Published: August 2021

Abstract
Background
COVID19 is a global pandemic that threatens all nations. As there is no effective antiviral drug for COVID19, we examined the potency of natural ingredients against the SARS-CoV-2 main protease (PDB ID 6YNQ). Buah merah is a typical fruit from Papua, Indonesia, which is known to contain high levels of carotenoids and flavonoids. The contents have been proven to be effective as antiparasitic and anti-HIV. An in silico approach to 16 metabolites of buah merah (Pandanus conoideus Lamk) was carried out using AutoDock Vina. Furthermore, the study of the dynamics of ligand–protein interactions was carried out using CABS Flex 2.0 server to determine the test ligand and receptor complexes' stability. ADMET prediction was also carried out to study the pharmacokinetic profile of potential antiviral candidates.

Result
The docking results showed that 3 of the 16 buah merah metabolites were potent inhibitors against the SARS-CoV-2 main protease. The flavonoid compounds are quercetin 3′-glucoside, quercetin 3-O-glucose, and taxifolin 3-O-α-arabinopyranose with a binding affinity of − 9.7, − 9.3, and − 8.8, respectively, with stable ligand–protein complex. ADMET study shows that the three compounds are easily dissolved, easily absorbed orally and topically, have a high unbound fraction, low toxicity, and non-irritant.

Conclusion
We conclude that quercetin 3′-glucoside, quercetin 3-O-glucose, and taxifolin 3-O-α-arabinopyranose can be used and improved as potential anti-SARS-CoV-2 agents in further study.