bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Call to Transform Maternal and Child Health Mentorship to Build Inclusivity, Honor Diversity of Experiences, and Tackle the Root of Health Disparities
Authors: Mishkin Kathryn E. , Ramirez Grace Guerrero , Odusanya Anne , Kaufman Benjamin 
Published: November 2021

Abstract
Introduction
Mentorship should be a transformative experience that propels mentees from one point in their career to another and drives personal growth. Within the field of maternal and child health (MCH), it is considered a critical professional duty. However, MCH has yet to explicitly embrace mentorship practice as a means to address workforce challenges including turnover, knowledge loss, and undue burden on the part of historically oppressed individuals and communities to overturn oppressive systems.

Call to Action
We advocate for public calls for diversity and equity to be met with strategic enhancement of the practice of MCH mentorship. Transformative MCH mentorship should be used to promote positive identity formation, understanding of self in context, efficacy, and sustained commitment to working with MCH populations in ways that are inclusive and prevent the perpetration of the problematic power dynamics that lead to inequitable outcomes.

Recommendations
We present recommendations to strengthen MCH mentorship practice. At the individual level, there should be a refreshment of norms and expectations, where mentorship is seen as a uniquely flexible opportunity for mutual learning. At the organizational level, embedding mentorship in all aspects of practice helps establish and sustain a culture of belonging. This transformative organizational culture can attract and retain future generations of professionals that are not only more representative of the populations that MCH programs support but are prepared to authentically elevate the needs and strengths of those populations. These suggestions incorporate best practices from other fields and include ideas for the MCH field in particular.
Strictly Human: Limitations of Autonomous Systems
Authors: Soltanzadeh Sadjad 
Published: November 2021

AbstractCan autonomous systems replace humans in the performance of their activities? How does the answer to this question inform the design of autonomous systems? The study of technical systems and their features should be preceded by the study of the activities in which they play roles. Each activity can be described by its overall goals, governing norms and the intermediate steps which are taken to achieve the goals and to follow the norms. This paper uses the activity realist approach to conceptualize autonomous systems in the context of human activities. By doing so, it first argues for epistemic and logical conditions that illustrate the limitations of autonomous systems in tasks which they can and cannot perform, and then, it discusses the ramifications of the limitations of system autonomy on the design of autonomous systems.
Emotional Availability as a Moderator of Stress for Young Children and Parents in Two Diverse Early Head Start Samples
Authors: Senehi Neda , Flykt Marjo , Biringen Zeynep , Laudenslager Mark L. , Watamura Sarah Enos , Garrett Brady A. , Kominsky Terrence K. , Wurster Hannah E. , Sarche Michelle 
Published: November 2021

AbstractPositive parent–child relationship quality is critical for buffering children from the effects of stress on development. It is thus vital to develop interventions that target parent–child relationship quality for families experiencing stress. We examined the moderating role of parent–child relationship quality (as measured by parental emotional availability [EA]) in the intergenerational association between parental adverse childhood experiences (ACEs) and their young children’s hair cortisol concentrations (HCCs)—a physiological marker of cumulative hypothalamic pituitary adrenal (HPA)-axis activity. Using data from 127 parent–child dyads collected by two of six ACF-funded Buffering Toxic Stress consortium sites, we tested interaction effects of parental ACEs with parental EA on young children’s (Mage = 18.38, SDage = 7.10) HCC. Results revealed curvilinear main effects such that higher parental ACEs were significantly associated with greater HCC and stronger associations occurred at higher levels of parental ACEs. However, this association was moderated by parental EA. Thus, among children with higher parental history of ACEs, children of parents with higher EA had lower HCC compared to children of parents with lower EA. These findings provide support for the risk-buffering and risk-exacerbating role of parent–child relationship quality (e.g., EA) for the transmission of parents’ early life adversity on their children’s HPA-axis activity, documented here in a racially and ethnically diverse sample of children and parents served by Early Head Start. Findings suggest that intervention and prevention efforts targeting stress response in children of mothers with childhood adversity should also support parents in building an emotionally available relationship with their children.
Assessing fatigue in children and adolescents: Psychometric validation of the German version of the PROMIS® Pediatric Short Form v2.0 - Fatigue 10a in school children and pediatric chronic pain patients
Authors: Sommer Ariane , Grothus Susanne , Grochowska Kamila , Claus Benedikt B. , Stahlschmidt Lorin , Wager Julia 
Published: November 2021

Abstract
Purpose
Fatigue is a common symptom in children and adolescents. Its negative impact on health outcomes is even more pronounced in those with chronic pain. There is currently no fatigue measurement tool in German that is validated for both children and adolescents with and without chronic pain. Therefore, this study aimed to gather quantitative validity evidence to support the use of the German version of the PROMIS® Pediatric Short Form v2.0 - Fatigue 10a (PROMIS® F-SF) in the German pediatric general population as well as in German pediatric chronic pain patients.

Methods
The 10-item self-assessment questionnaire was validated in a sample of N = 1348 school children (9–18 years; 52.4% female) and N = 114 pediatric chronic pain patients (8–17 years; 63.3% female). Construct and convergent validity, reliability, and item and scale characteristics were examined.

Results
Confirmatory factor analyses showed sufficient model fit for the 1-factor model of the questionnaire (school sample: CFI = 0.94, RMSEA = 0.10, SRMR = 0.04; patient sample: CFI = 0.90, RMSEA = 0.14, SRMR = 0.05). Convergent validity was supported by weak-to-large significant correlations with sleep quality, health-related quality of life (HRQoL), and pain characteristics. The questionnaire had excellent internal consistency in both samples (α = 0.92 and α = 0.93). Sex differences and age distributions of the PROMIS® F-SF showed that girls reported significantly higher fatigue than boys and that fatigue increased with age.

Conclusion
The PROMIS® F-SF is a reliable instrument with good psychometric properties. Preliminary evidence is provided that the questionnaire validly measures fatigue in children and adolescents with and without chronic pain.
Introducing a bibliometric index based on factor analysis
Authors: Valderrama Pilar , Jiménez-Contreras Evaristo , Escabias Manuel , Valderrama Mariano J. 
Published: November 2021

AbstractThis work applies a factor analysis with VARIMAX rotation to develop a bibliometric indicator, named the Weighted Factor Index, in order to derive a new classification for journals belonging to a certain category, alternative to the one provided by the Journal Impact Factor. For this, 16 metrics from three different databases (Web of Science, Scopus and SCImago Journal Rank) are considered. The Weighed Factor Index entails the advantage of incorporating and summarizing information from all the indicators; so as to test its performance, it was applied to rank journals belonging to the category Information Science & Library Science.
Warning, or Manipulating in Pandemic Times? A Critical and Contrastive Analysis of Official Discourse Through the English and Spanish News
Authors: Orts María Ángeles , Vargas-Sierra Chelo 
Published: November 2021

AbstractFocusing on media discourse and adopting a Critical Discourse Analysis—linguistic and rhetorical—perspective, this paper explores the role of the media in influencing citizens’ behaviour towards the COVID-19 crisis. The paper evaluates the set of potentially persuasive lexical items and emotional implicatures used by two quality newspapers, i.e. The Guardian (UK edition) and El País (Spain edition), to report on the pandemic during the three waves—the periods between the onset and trough of virus contamination—that occurred until March 2021. A representative, ad-hoc, comparable corpus (COVIDWave_EN and COVIDWave_ES) was compiled in English and Spanish comprising the news on the pandemic that appeared in the aforementioned newspapers during the three established time periods. The corpora were uploaded to Sketch Engine, which was used to first detect and analyse different categories (nouns, verbs, and adjectives) of word frequency, and then assign negative or positive polarity. Lexical keyness was secondly analysed to categorize emotional implicatures of control, metaphors, signals of epistemic asymmetry and positive implicatures in order to discern how they become weapons of negative or positive persuasion. The ultimate end of the study was to critically analyse and contrast the lexicon and rhetoric used by these two newspapers during this time period so as to unveil the stance taken by governments and health institutions—voices of authority—to disseminate words of control and persuasion with the aim of exerting influence on the behaviour of citizens in UK and Spain.
Italian experience with rVIII-single chain: a survey of patients with haemophilia A and their physicians
Authors: Borchiellini Alessandra , Castaman Giancarlo , Feola Giulio , Ferretti Antonietta , Giordano Paola , Luciani Matteo , Malcangi Giuseppe , Margaglione Maurizio , Molinari Angelo Claudio , Pollio Berardino , Rocino Angiola , Santoro Cristina , Schiavulli Michele , Zanon Ezio 
Published: November 2021

AbstractrVIII-SingleChain is indicated for treatment and prophylaxis of bleeding in patients with haemophilia A (HA). The safety and efficacy of rVIII-SingleChain have previously been shown in the AFFINITY clinical trial programme. This survey evaluated clinical experience following a switch to rVIII-SingleChain from the perspective of both physicians and patients. A web-based survey (July–September 2019) involving 14 Haemophilia Treatment Centres (HTCs) collected data about HA patients who were under treatment with rVIII-SingleChain for ≥ 12 months, as reported by their physicians. In addition, about half of these patients were separately interviewed. Out of 91 patients receiving rVIII-SingleChain in the 14 participating HTCs, 48 had been treated for ≥ 12 months; among those 48, 38% were ≤ 18 years, 37% 19–40 years and 25 % ≥ 41 years; 73% of them had severe HA and 85% were being treated with prophylactic therapy. Twenty-six patients accepted to be separately interviewed: mean age was 30 years; 62% had severe HA and 85% were receiving prophylaxis. Focusing on those patients who were already in prophylaxis with prior FVIII (all but one with recombinant factors), infusion frequency was significantly reduced from 3–2 per week following the switch to rVIII-SingleChain (mean, 2.74 vs. 2.44, respectively; p=0.013), as reported by physicians; the rate of patients needing 3 infusions per week dropped from 74% with previous products to 44% with rFVIII-SingleChain. The annual mean factor consumption was 4740 IU/Kg (median, 4500 IU/Kg; min, 2.215 IU/Kg; max, 7.200 IU/Kg) with prior product and 4320 IU/Kg (median, 4320 IU/Kg; min, 2.215 IU/Kg; max, 6.646 IU/Kg) with rVIII-SingleChain. Both physicians and patients reported a significant reduction in annual total bleeding rates with rVIII-SingleChain compared with prior product (mean 2.15–0.96 and 2.46–0.71 events/year, p = 0.031 and p = 0.018, respectively). Mean satisfaction ratings (from 1; dissatisfied, to 5; very satisfied) for rVIII-SingleChain were quite high for both physicians (4.14, 86% satisfied/very satisfied) and patients (4.18, 86% satisfied/very satisfied). This survey suggested that switching to rVIII-SingleChain allowed patients to reduce their injection frequency without increasing factor consumption or compromising clinical results. Both physicians and patients reported a positive experience with rVIII-SingleChain after 1 year of treatment.
Emerging needs of social innovators and social innovation ecosystems
Authors: Audretsch David B. , Eichler Georg M. , Schwarz Erich J. 
Published: November 2021

AbstractSocial innovations (SIs) contribute to solving or at least mitigating many of the most pressing grand challenges. Similar to profit-oriented innovations, which are mainly developed by existing organizations and profit-oriented entrepreneurs, SIs are mainly developed and implemented by existing organizations and individual actors - social innovators. While much of the existing literature examines the needs of profit-oriented entrepreneurs and suggests entrepreneurial ecosystems as an adequate approach for satisfying profit-oriented entrepreneurs’ needs, little is known about the emerging needs of social innovators. By conducting an in-depth qualitative analysis of an exemplary territorial context based on 28 semistructured interviews and secondary data collection, this exploratory study aims to shed light on the emerging needs of social innovators. Furthermore, through an analysis of the identified needs, the study explores similarities and differences between the social innovation ecosystem and the entrepreneurial ecosystem. Thus, Isenberg’s entrepreneurial ecosystem model is leveraged for the development of a novel social innovation ecosystem model.
Memory over matter?—a conceptual framework to integrate social–ecological l legacies in agricultural NCP co-production
Authors: Grosinger Julia , Potts Matthew D. , Buclet Nicolas , Lavorel Sandra 
Published: November 2021

AbstractTo better account for how social–ecological legacies of social and ecological systems jointly shape the current composition, the quality and quantity of nature’s contribution to people (NCPs), we integrate the concept of NCP co-production into social–ecological system thinking. Our expanded framework highlights how NCP co-production is frequently entangled within its social–ecological context, such as legacies, current resources and social activities. Additionally, we underline the relevance of non-material and material dimensions of resources in NCP co-production. To illustrate the potential of this expanded framework, we explore its application to an agricultural system of the French Northern Alps. We conclude that this framework (1) facilitates the understanding of society–ecosystem interactions in a specific regional social–ecological context; (2) helps to better conceptualise the interdependencies between resources and social activities; (3) demonstrates how current rule sets to organise social–ecological legacies affect the entire NCP co-production chain. The framework’s further implementation requires more research to better understand the complex interlinkages between the social and the ecological subsystems that underpin socioeconomic activities.
Axiomatization of Some Basic and Modal Boolean Connexive Logics
Authors: Klonowski Mateusz 
Published: November 2021

AbstractBoolean connexive logic is an extension of Boolean logic that is closed under Modus Ponens and contains Aristotle’s and Boethius’ theses. According to these theses (i) a sentence cannot imply its negation and the negation of a sentence cannot imply the sentence; and (ii) if the antecedent implies the consequent, then the antecedent cannot imply the negation of the consequent and if the antecedent implies the negation of the consequent, then the antecedent cannot imply the consequent. Such a logic was first introduced by Jarmużek and Malinowski, by means of so-called relating semantics and tableau systems. Subsequently its modal extension was determined by means of the combination of possible-worlds semantics and relating semantics. In the following article we present axiomatic systems of some basic and modal Boolean connexive logics. Proofs of completeness will be carried out using canonical models defined with respect to maximal consistent sets.
A Novel Long-Noncoding RNA LncZFAS1 Prevents MPP+-Induced Neuroinflammation Through MIB1 Activation
Authors: Zhu Ziman , Huang Peiling , Sun Ruifeng , Li Xiaoling , Li Wenshan , Gong Weijun 
Published: November 2021

AbstractParkinson’s disease remains one of the leading neurodegenerative diseases in developed countries. Despite well-defined symptomology and pathology, the complexity of Parkinson’s disease prevents a full understanding of its etiological mechanism. Mechanistically, α-synuclein misfolding and aggregation appear to be central for disease progression, but mitochondrial dysfunction, dysfunctional protein clearance and ubiquitin/proteasome systems, and neuroinflammation have also been associated with Parkinson’s disease. Particularly, neuroinflammation, which was initially thought to be a side effect of Parkinson’s disease pathogenesis, has now been recognized as driver of Parkinson’s disease exacerbation. Next-generation sequencing has been used to identify a plethora of long noncoding RNAs (lncRNA) with important transcriptional regulatory functions. Moreover, a myriad of lncRNAs are known to be regulators of inflammatory signaling and neurodegenerative diseases, including IL-1β secretion and Parkinson’s disease. Here, LncZFAS1 was identified as a regulator of inflammasome activation, and pyroptosis in human neuroblast SH-SY5Y cells following MPP+ treatment, a common in vitro Parkinson’s disease cell model. Mechanistically, TXNIP ubiquitination through MIB1 E3 ubiquitin ligase regulates NLRP3 inflammasome activation in neuroblasts. In contrast, MPP+ activates the NLPR3 inflammasome through miR590-3p upregulation and direct interference with MIB1-dependent TXNIP ubiquitination. LncZFAS overexpression inhibits this entire pathway through direct interference with miR590-3p, exposing a novel research idea regarding the mechanism of Parkinson’s disease.
Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines
Authors: García-Alfonso P. , Saiz-Rodríguez M. , Mondéjar R. , Salazar J. , Páez D. , Borobia A. M. , Safont M. J. , García-García I. , Colomer R. , García-González X. , Herrero M. J. , López-Fernández L. A. , Abad-Santos F. 
Published: November 2021

Abstract5-Fluorouracil (5-FU) and oral fluoropyrimidines, such as capecitabine, are widely used in the treatment of cancer, especially gastrointestinal tumors and breast cancer, but their administration can produce serious and even lethal toxicity. This toxicity is often related to the partial or complete deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme, which causes a reduction in clearance and a longer half-life of 5-FU. It is advisable to determine if a DPD deficiency exists before administering these drugs by genotyping DPYD gene polymorphisms. The objective of this consensus of experts, in which representatives from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology participated, is to establish clear recommendations for the implementation of genotype and/or phenotype testing for DPD deficiency in patients who are candidates to receive fluoropyrimidines. The genotyping of DPYD previous to treatment classifies individuals as normal, intermediate, or poor metabolizers. Normal metabolizers do not require changes in the initial dose, intermediate metabolizers should start treatment with fluoropyrimidines at doses reduced to 50%, and poor metabolizers are contraindicated for fluoropyrimidines.
Physicians’ perspectives on adverse drug reactions in pediatric routine care: a survey
Authors: Neininger Martina P. , Jeschke Sarah , Kiesel Lisa M. , Bertsche Thilo , Bertsche Astrid 
Published: November 2021

Abstract
Background
Children and adolescents are at particular risk for adverse drug reactions (ADRs). We investigated physicians’ perceptions on ADRs in pediatric routine care.

Methods
In this exploratory study from April to November 2020, we invited physicians treating pediatric patients across Germany to complete an online questionnaire consisting mainly of closed questions.

Results
Completion rate was 98% (127/129). Of all participants, 23% (29/127) stated they were not able to estimate how many of their pediatric patients experienced ADRs during drug therapy. The remaining physicians estimated that 7.5% (median; Q25/Q75 3%/20%) of their pediatric patients were affected by ADRs. Regarding counseling on ADRs, 61% (77/127) stated they do not ask regularly the extent to which parents want to be informed. In total, 26% (33/127) stated they avoid counseling on ADRs concerning commonly used approved therapies, whereas only 4% (5/127) did so concerning off-label use (P < 0.001). Altogether, 16% (20/127) stated they rather prescribe new medicines as they hope for better effectiveness; 72% (91/127) said they are cautious about doing so owing to yet unknown ADRs. Of all respondents, 46% (58/127) stated they do not report ADRs to the authorities. Concerning the black triangle symbol, a European pharmacovigilance measure, 11% (14/127) stated they knew it and 6% (7/127) stated they reported any suspected ADR for drugs with that symbol.

Conclusions
Physicians’ perspectives on ADRs were ambivalent: ADRs influenced their parent counseling and drug prescribing; yet, they struggled to estimate the impact of ADRs on their patients and were not aware of specific pharmacovigilance measures.
Clustering of Modifiable Behavioral Risk Factors and Their Association with All-Cause Mortality in Taiwan’s Adult Population: a Latent Class Analysis
Authors: Kukreti Shikha , Yu Tsung , Chiu Po Wei , Strong Carol 
Published: November 2021

Abstract
Background
Modifiable risk behaviors, such as smoking, diet, alcohol consumption, physical activity, and sleep, are known to impact health. This study aims toward identifying latent classes of unhealthy lifestyle behavior, exploring the correlations between sociodemographic factors, identifying classes, and further assessing the associations between identified latent classes and all-cause mortality.

Methods
For this study, the data were obtained from a prospective cohort study in Taiwan. The participants’ self-reported demographic and behavioral characteristics (smoking, physical activity, alcohol consumption, fruit and vegetable intake, and sleep) were used. Latent class analysis was used to identify health-behavior patterns, and Cox proportional hazard regression analysis was used to find the association between the latent class of health-behavior and all-cause mortality.

Results
A complete dataset was obtained from 290,279 participants with a mean age of 40 (12.4). Seven latent classes were identified, characterized as having a 100% likelihood of at least one unhealthy behavior coupled with the probability of having the other four unhealthy risk behaviors. This study also shows that latent health-behavior classes are associated with mortality, suggesting that they are representative of a healthy lifestyle. Finally, it appeared that multiple risk behaviors were more prevalent in younger men and individuals with low socioeconomic status.

Conclusions
There was a clear clustering pattern of modifiable risk behaviors among the adults under consideration, where the risk of mortality increased with increases in unhealthy behavior. Our findings can be used to design customized disease prevention programs targeting specific populations and corresponding profiles identified in the latent class analysis.