bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regular use of non-steroidal anti-inflammatory drugs can effectively control pain and global health in patients with moderate activity of rheumatoid arthritis
Authors: Karateev A. E. , Pogozheva E. Yu. , Amirdzhanova V. N. , Filatova E. S. , Nesterenko V. A. 
Published: April 2021

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to control pain in rheumatoid arthritis (RA). However, many aspects of the therapeutic effect of NSAIDs in RA have not been sufficiently studied. In particular, this concerns the effect of NSAIDs on the inflammatory activity of the disease.Objective: to study the comparative efficacy and safety of NSAIDs in RA patients with moderate and low disease activity.Patients and methods. The study group consisted of 404 patients with RA, 69% women and 31% men, mean age 58.6±10.0 years, with moderate and low disease activity – DAS28<5.1 (mean value 3.7±1.5), who initially had moderate or severe pain: >4 cm on the visual analog scale (VAS) 0–10 cm. All patients received DMARDs, mostly methotrexate 15 to 25 mg weekly, 8.2% biological agents, 18.6% glucocorticoids. All patients were prescribed NSAIDs at the full therapeutic dose. The results of treatment were evaluated after 2 weeks, 1, 3 and 6 months. Criteria of efficacy were the dynamics of pain (10 cm VAS), Patient Global Health (PGH on a 10-cm VAS), the change in the tender joints count (TJC) and swollen joints count(SJC), and dynamics of RA activity (DAS28).Results and discussion. 54.2% of patients received aceclofenac, 19.8% nimesulide, 14.3% meloxicam, 9.1% diclofenac, 2.6% – other NSAIDs. After 2 weeks, the pain decreased from 6.3±1.2 cm to 4.5±1.5 cm on VAS (p<0.001). The severity of pain continued to decrease further, and after 6 months of observation was 4.0±1.2 (p< 001, compared with the baseline level). A similar result was observed for the TJC, SJC, and PGH: the dynamics of these indicators, in comparison with the baseline level, was statistically significant after 2 weeks and after 1, 3, and 6 months of observation (p< 0.05). There was a decrease in the disease activity by DAS28: from 3.7±1.5 to 3.4±1.1 after 3 months (p=0.041) and 3.1±0.9 after 6 months (p=0.02). The effectiveness of aceclofenac and other NSAIDs for pain reduction, TJC, SJC, PGH and DAS28 did not differ. The tolerability of aceclofenac was better than of other NSAIDs: the frequency of dyspepsia after 2 weeks was 23.3% and 36.2% (p=0.004). The frequency of arterial hypertension and edema in patients who used aceclofenac, after 2 weeks and 6 months was slightly lower than in patients treated with other NSAIDs, but the difference was not statistically significant.Conclusion. The use of NSAIDs can effectively control the pain and other symptoms of RA, as well as the disease activity by DAS28 in patients with moderate or low disease activity. Aceclofenac is not inferior to other NSAIDs in analgesic potential and exceeds them in tolerability.
MAKNA DAN PERUBAHAN RELASI GENDER BAGI PEREMPUAN PEKERJA DADAKAN DI MASA PANDEMI COVID-19
Authors: Setiyono Ditha Aziezah , Imelda Johanna Debora 
Published: April 2021

2020 is a historic year due to the outbreak of the Covid-19 virus. As a result, people are forced to adapt to a new normal situation, which changes their daily lives order. In this condition, women are experiencing a double burden, including when men, as 'breadwinners', has experiencing the termination of employment (PHK) or decreasing in his income. There are various ways that women do for supporting their children and family needs. Such as being an unexpected worker. This study aims to provide an explanation on the meaning of being an unepected worker and gender relation changes using Bourdieu perspective. The research method employed is descriptive qualitative, using a case study. Data are collected through in-depth interviews, observation, and documentation. The results showed that the meaning of becoming an unexpected worker and the process of gender relations changes cannot be separated from the habitus of women. Work has economic and non-economic meaning when workers become impromptu workers. In the context of changing gender relations, the higher level of women education, the more parallel the gender relations are formed. Vice versa, the lower of their educations, the more domination of men in a gender relation. Tahun 2020 menjadi tahun bersejarah karena merebaknya virus Covid-19, akibatnya masyarakat mengubah tata cara kehidupan sehari-hari. Dalam kondisi ini, perempuan menjadi pihak yang harus bekerja ekstra, termasuk saat laki-laki sebagai 'income earner' mengalami Pemutusan Hubungan Kerja (PHK) atau pengurangan pendapatan. Berbagai cara dilakukan perempuan untuk anak dan kelangsungan keluarga, salah satunya dengan menjadi perempuan pekerja dadakan. Penelitian ini bertujuan untuk memberi gambaran makna menjadi pekerja dadakan dan perubahan relasi gender yang terjadi denga menggunakan teori sosial Bourdeui. Metode penelitian yang digunakan penelitian kualitatif deskriptif dengan jenis studi kasus. Pengumpulan data dilakukan melalui wawancara mendalam, observasi dan dokumentasi. Hasil penelitian menunjukan makna menjadi pekerja dadakan dan perubahan relasi gender tersebut tidak lepas dari habitus perempuan. Terdapat makna ekonomi dan non-ekonomi saat perempuan menjadi pekerja dadakan. Dalam konteks perubahan relasi gender semakin tinggi tingkat pendidikan semakin sejajar relasi gender yang terbentuk. Begitu pula sebaliknya, semakin rendah tingkat pendidikan semakin perempuan didominasi oleh laki-laki dalam sebuah relasi gender.
DEKONSTRUKSI KARAKTER DRUPADI DALAM PEWAYANGAN (STUDI GENDER DAN LIVING QUR’AN MENGENAI POLIANDRI)
Authors: Hidayatullah Ahmad , Bakhri Syamsul 
Published: April 2021

One of the many evidences about the concepts of justice and gender equality in Islam can be seen in the creation of the plot and of a central female character in the Javanese puppet, namely Drupadi. This article employs a qualitative research with this literature study approach to determine the deconstruction character of Drupadi. The validity of the data is obtained by triangulating data sources and integrating data from journals and books about Drupadi characters in puppets, supported by analysis of gender studies and living Qur'an studies of the concept of polyandry. The results showed that there is a deconstruction of the character of Drupadi figures from the Hindu to the Islamic version. Drupadi, who is described in the Mahabharata story of having five husbands, in a Javanese puppet show, especially after the arrival of Islam, is described only married to Yudhistira. The deconstruction of Drupadi's character as a symbol of women is no longer objectified. Drupadi's new character reflects equality between men and women in Islam.Satu dari sekian bukti tentang adanya konsep keadilan dan kesetaraan gender dalam Islam bisa dilihat dalam pembangunan alur dan karakter tokoh perempuan sentral pada pewayangan Jawa, yakni Drupadi. Penelitian kualitatif dengan pendekatan studi pustaka ini, bertujuan untuk menentukan dekonstruksi karakter Drupadi di Wayang. Validitas data diperoleh dengan melakukan triangulasi sumber data, mengintegrasikan data dari jurnal dan buku tentang karakter Drupadi dalam wayang dengan berfokus pada analisis studi gender dan Living Qur’an mengenai poliandri. Hasil penelitian menunjukkan bahwa telah terjadi dekonstruksi karakter tokoh Drupadi dari versi Hindu ke versi Islam; Drupadi dalam cerita Mahabharata melakukan Poliandri dengan 5 suami, dalam pewayangan Jawa setelah datangnya Islam hanya bersuamikan Yudhistira. Dekonstruksi karakter Drupadi menjadi simbol bahwa perempuan tidak lagi menjadi objektifikasi seksual. Karakter Drupadi yang baru mencerminkan kesetaraan antara pria dan perempuan dalam ajaran Islam.
False-seronegative HCV infection motivated by interference with cryoglobulins
Authors: Recio Comí Gemma , Molina Clavero Carmen , Calabuig Ballester Sandra , Benavent Bofill Clara , Picó-Plana Ester , Martín Grau Carla , Gutiérrez Fornés Cristina , Sans Mateu Ma Teresa 
Published: April 2021

Abstract

Objectives
Cryoglobulins (CGs) are serum proteins that undergo a reverse cold-induced precipitation in vitro. The CGs are a well-known cause of analytical interferences in several laboratory tests, leading to spurious results. With this in view, we present a case of a patient initially misdiagnosed due to CGs interference in Hepatitis C Virus (HCV) serology.

Case presentation
We report a case of a woman of advanced age affected by acute renal failure that required urgent haemodialysis. In the absence of infections and other causes of CGs production, a diagnosis of acute renal failure secondary to essential cryoglobulinemia was established. However, an unexpected positive HCV viral load was encountered. At this point, a false-seronegative HCV infection conditioned to CGs interference in vitro was suspected, confirmed by repeating serology in pre-warmed serum. Finally, the patient was correctly diagnosed with HCV-secondary cryoglobulinemia.

Conclusions
As shown in the case, the presence of CGs in blood may represent a challenge for the correct interpretation of several laboratory tests. The identification of CGs and the pre-treatment of serum are decisive to avoid spurious results and reach a genuine diagnosis.
A Redistributed Bundle Algorithm Based on Local Convexification Models for Nonlinear Nonsmooth DC Programming
Authors: Shen Jie , Xu Na , Guo Fang-Fang , Li Han-Yang , Hu Pan 
Published: April 2021

Abstract
For nonlinear nonsmooth DC programming (difference of convex functions), we introduce a new redistributed proximal bundle method. The subgradient information of both the DC components is gathered from some neighbourhood of the current stability center and it is used to build separately an approximation for each component in the DC representation. Especially we employ the nonlinear redistributed technique to model the second component of DC function by constructing a local convexification cutting plane. The corresponding convexification parameter is adjusted dynamically and is taken sufficiently large to make the ”augmented” linearization errors nonnegative. Based on above techniques we obtain a new convex cutting plane model of the original objective function. Based on this new approximation the redistributed proximal bundle method is designed and the convergence of the proposed algorithm to a Clarke stationary point is proved. A simple numerical experiment is given to show the validity of the presented algorithm.
Gonadotropins for testicular descent in cryptorchid congenital hypogonadotropic hypogonadism males beyond infancy
Authors: Sharma Shreya , Shah Ravikumar , Patil Virendra , Lila Anurag R. , Sarathi Vijaya , Shah Nalini , Bandgar Tushar 
Published: April 2021

Abstract

Objectives
To study the effect of combined gonadotropin therapy (CGT) on testicular descent ± spermatogenesis in congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism beyond infancy.

Methods
This retrospective cohort study included CHH patients with cryptorchidism [bilateral (n=5) or unilateral (n=1)] treated with CGT for testicular descent ± pubertal induction. All participants were treated with CGT [human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG)] with hMG pretreatment in three and monitored for changes in testicular volume (TV), serum total testosterone (T), serum inhibin-B, and sperm concentration.

Results
Complete testicular descent to the scrotal position was achieved in 5/6 patients (10/11 testes) after 4.7 ± 1.6 months of treatment. There was 44 ± 18%, 97.5% (IQR: 44–195), 10-fold (IQR: 3–19.6), and two-fold (IQR: 1.7–9.3) increase in stretched penile length, ultrasound measured TV, T level, and serum inhibin-B from baseline, respectively. In two pediatric cases, testicular descent occurred with isolated hMG therapy. At the last follow up (median: 23.5, IQR: 10.5–38.7 months), all the descended testes remained in scrotal position. In four pubertal/postpubertal age patients, continuous CGT (18–60 months) yielded T and inhibin-B levels of 16.64 ± 1.46 nmol/l and 106 ± 32.6 pg/mL, respectively. All the three patients with available semen analysis had sperm concentration of ≥5 million/mL and one of them achieved paternity.

Conclusions
A trial of CGT before orchiopexy may be considered in CHH males with cryptorchidism even beyond the narrow age-window of infancy. CGT may also have beneficial effects on future spermatogenesis and fertility outcomes in these patients.
The Role of School Libraries in Supporting Inquiry-Based Methods for Teaching Science in Nigerian Schools: Challenges and Possibilities
Authors: Olajide Olabode , Zinn Sandy 
Published: April 2021

Abstract
Using a constructivist lens, this study investigated the role of school libraries in supporting an inquiry-based approach for teaching and learning science subjects in senior secondary schools in Ekiti State, Nigeria, the challenges faced and possibilities presented. The significance of this study is based on the importance Nigeria has assigned to science education as a means to achieving national development. A mixed-methods approach was chosen for the study. The population of the study included school librarians, principals, and science teachers in public senior secondary schools as well as staff in the Ministry of Education, Science and Technology concerned with supporting and managing resources for science teaching and learning. Data was collected using questionnaires, interviews, and observation. Quantitative data collected through the questionnaires were analyzed using the SPSS, while qualitative data were transcribed and thematically analyzed. The findings revealed the library resource most frequently available in school libraries for supporting science curriculum implementation is a textbook. Most of the staff in charge of the library had no librarianship qualification. Teacher-centred approaches predominated amongst teachers. The study emphasizes how school libraries are underrated as support for the curriculum. It proffers some far reaching recommendations to position school libraries for better performance.
Driving plasmonic nanoantennas at perfect impedance matching using generalized coherent perfect absorption
Authors: Grimm Philipp , Razinskas Gary , Huang Jer-Shing , Hecht Bert 
Published: April 2021

Abstract
Coherent perfect absorption (CPA) describes the absence of all outgoing modes from a lossy resonator, driven by lossless incoming modes. Here, we show that for nanoresonators that also exhibit radiative losses, e.g., plasmonic nanoantennas, a generalized version of CPA (gCPA) can be applied. In gCPA outgoing modes are suppressed only for a subset of (guided plasmonic) modes while other (radiative) modes are treated as additional loss channels - a situation typically referred to as perfect impedance matching. Here we make use of gCPA to show how to achieve perfect impedance matching between a single nanowire plasmonic waveguide and a plasmonic nanoantenna. Antennas with both radiant and subradiant characteristics are considered. We further demonstrate potential applications in background-free sensing.
The crystal structure of 4-(6-acetyl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidin-7-yl)benzonitrile, C14H12N6O
Authors: Wang Wenxiang 
Published: April 2021

Abstract
C14H12N6O, monoclinic, P21/c (no. 14), a = 17.827(4) Å, b = 11.021(2) Å, c = 7.0936(14) Å, β = 100.59(3)°, V = 1370.0(5) Å3, Z = 4, R

gt
(F) = 0.0824, wR

ref
(F
2) = 0.2208, T = 293 K.
CRISPR/Cas-based Diagnostics and Gene Therapy
Authors: Qiu Meiyu , Li Pei 
Published: April 2021

Abstract
Clustered regularly interspaced short palindromic repeats (CRISPR) technology, an easy, rapid, cost-effective, and precise gene-editing technique, has revolutionized diagnostics and gene therapy. Fast and accurate diagnosis of diseases is essential for point-of-care-testing (POCT) and specialized medical institutes. The CRISPR-associated (Cas) proteins system shed light on the new diagnostics methods at point-of-care (POC) owning to its advantages. In addition, CRISPR/Cas-based gene-editing technology has led to various breakthroughs in gene therapy. It has been employed in clinical trials for a variety of untreatable diseases, including cancer, blood disorders, and other syndromes. Currently, the clinical application of CRISPR/Cas has been mainly focused on ex vivo therapies. Recently, tremendous efforts have been made in the development of ex vivo gene therapy based on CRISPR-Cas9. Despite these efforts, in vivo CRISPR/Cas gene therapy is only in its initial stage. Here, we review the milestones of CRISPR/Cas technologies that advanced the field of diagnostics and gene therapy. We also highlight the recent advances of diagnostics and gene therapy based on CRISPR/Cas technology. In the last section, we discuss the strength and significant challenges of the CRISPR/Cas technology for its future clinical usage in diagnosis and gene therapy.
Changes of Korean Education and the Fourth Industrial Revolution / Promjene korejskoga obrazovnog sustava i četvrta industrijska revolucija
Authors: Park Yoon-cheol 
Published: April 2021

A society’s reality should be reflected in education, that is, educational methods need to keep up with the times. The purpose of this research is to examine the educational methods for the era of the Fourth Industrial Revolution in the education system of Korea. The sample of the research targeted the Korean education system from 1960 to the present in the context of the Fourth Industrial Revolution. A literature review and a descriptive approach were applied to analyze the sample, and the findings indicate that the education system of Korea may be classified into three stages from 1960 to the present. The first stage was nationalism, driven by the government, from 1960 to 1994; the second stage was liberalism, which emphasized autonomy, from 1995 to 2015; and the third stage was creativity for the era of the Fourth Industrial Revolution, from 2016 to the present. These results indicate that the education stages of nationalism and liberalism still exist in Korea and that past education methods, such as mass education, have not been replaced. The Fourth Industrial Revolution requires fusion and collaboration in the education sector, and a personalized learning system, which values individual talents, experiences and aptitudes, will expectedly be a crucial factor in determining the educational methods of Korea in the Fourth Industrial Revolution, as this research suggests.Key words: collaboration; creativity; fusion; mass education; personalized learning system. --- Obrazovne potrebe trebaju odražavati stvarnost društva, a obrazovne metode ići u korak s vremenom. Cilj je ovoga istraživanja ispitati obrazovne metode u vremenu četvrte industrijske revolucije u obrazovnom sustavu Koreje. Uzorkom istraživanja obuhvaćen je korejski obrazovni sustav od 1960. do danas, u kontekstu četvrte industrijske revolucije. Za analizu uzorka korišteni su pregled literature i deskriptivni pristup. Rezultati pokazuju da se u obrazovnom sustavu Koreje od 1960. do danas mogu razlikovati tri stadija: prvi je nacionalizam, potaknut od strane vlade, od 1960. do 1994. godine; drugi je liberalizam, koji je naglašavao autonomiju, od 1995. do 2015. i treći, kreativnost tijekom četvrte industrijske revolucije, od 2016. do danas. Rezultati ovoga istraživanja pokazuju da su obrazovni stadiji nacionalizma i liberalizma još uvijek prisutni u Koreji i da obrazovne metode prošlosti, poput masovnoga obrazovanja, nisu prevladane. Četvrta industrijska revolucija zahtijeva stapanje i suradnju unutar obrazovnoga sektora, a očekuje se da personalizirani sustav učenja, koji vrednuje pojedinačne talente, iskustva i sklonosti, bude obrazovna metoda budućnosti korejskoga obrazovanja. Stoga, ovo istraživanje pokazuje da će personalizirani sustav učenja biti odlučujući čimbenik u određivanju obrazovnih metoda Koreje u periodu četvrte industrijske revolucije. Ključne riječi: kreativnost; masovno obrazovanje; personalizirani sustav učenja; stapanje; suradnja.
The Role of Formal Social Support to Students in the Context of the Social Dimension of Higher Education / Uloga formalne socijalne podrške studentima u kontekstu socijalne dimenzije visokoga obrazovanja
Authors: Šipuš Valentina , Milić Babić Marina 
Published: April 2021

This paper aims to present the development of the social dimension of higher education and the importance of developing social support through competent and professional counselling for students. The establishment of the European Higher Education Area (EHEA) and the social dimension of higher education dedicated to student support, ensued from the acknowledged need to advance higher education in the European Union. Along with different measures of student support (such as financial aid, streamlined administrative requirements for admission, institutional support in housing, transportation, food, and health care), social support services, such as guidance and counselling, equally represent a significant aspect of the social dimension. Dedicated institutional structures provide formal social support such as student counselling centres, which offer individual or group counselling and support students in overcoming the challenges of the academic experience. Finally, the activities concerning the social dimension of higher education focus on vulnerable groups, as well as the role and the importance of further developing counselling support at higher education institutions in Croatia.Keywords: counselling, higher education system; students --- Cilj je rada prikazati razvoj socijalne dimenzije visokoga obrazovanja te važnost razvoja socijalne podrške kroz stručno i profesionalno savjetovanje namijenjeno studentima. Svijest o potrebi unaprjeđenja visokoga obrazovanja u Europskoj uniji vodila je utemeljenju jedinstvenoga područja europskoga obrazovanja tzv. EHEA (European High Educatian Area) i unutar njega, posebnoga područja koje se bavi podrškom studiranju kroz tzv. socijalnu dimenziju visokoga obrazovanja. Uz različite mjere pomoći studentima u vidu financijskih potpora, jednostavnijih i olakšanih administrativnih pravila upisa, institucijske podrške u vidu stanovanja, prijevoza, hrane i zdravstvene pomoći. Važan dio te socijalne dimenzije odnosi se na usluge pružanja socijalne podrške u smislu usmjeravanja i savjetovanja. Formalna socijalna podrška ostvaruje se preko specijaliziranih institucionalnih usluga kao što su studentska savjetovališta koja nude usluge individualnoga ili grupnoga savjetovanja i pomagana studentima u prevladavanju izazova na koje nailaze u akademskom životu. Zaključno rad kroz socijalnu dimenziju visokoga obrazovanja stavlja fokus na ranjive skupine te ulogu i važnost daljnjega razvoja savjetovališne podrške na visokim učilištima u Hrvatskoj.Ključne riječi: savjetovanje; studenti; sustav visokoga obrazovanja