bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bibliometric Keyword and Term Analysis of the Articles Published in the Journal of Craniofacial Surgery Between 1995 and 2020
Authors: Bahşi Ayşe , Tekin Ahmet Mahmut , Bahşi Ilhan 
Published: July 2021

Abstract
The aim of this study is to analyze the terms in the abstract section and keywords of articles published in the Journal of Craniofacial Surgery (J Craniofac Surg) bibliometrically. Using the advanced search section in the Web of Science database on February 26, 2021, all articles published in the J Craniofac Surg from 1995 to 2020 were listed. All records of the detected 11,888 articles were exported and both terms in the abstract and keywords used in the articles were determined through the VOSviewer (version 1.6.16) software. It was found that the 10 most common terms in the abstract were patient (n: 6820), study (n: 4729), surgery (n: 3422), case (n: 3230), year (n: 2585), treatment (n: 2430), author (n: 2303) complication (n: 2150), month (n: 2061), and technique (n: 2002), respectively. It was found that the 10 most common keywords were craniosynostosis (n: 408), distraction osteogenesis (n: 257), orthognathic surgery (n: 243), mandible (n: 225), cleft palate (n: 214), reconstruction (n: 206), surgery (n: 157), cranioplasty (n: 150), cleft lip (n: 133), and computed tomography (n: 132), respectively. To the best of our knowledge, the current study is the first bibliometric keyword and term analysis in the field of craniofacial surgery. This study will enable us to have an idea about the past and current trends and the visibility of the articles published in the J Craniofac Surg.
Comparing Load-Sharing Miniplate and Load-Bearing Plate Fixation in Atrophic Edentulous Mandibular Fractures: A Systematic Review and Meta-Analysis
Authors: Seu Michelle , Jazayeri Hossein E. , Lopez Joseph , Khavanin Nima , Lake Isabel V. , Phillips Sarah , Reategui Alvaro , Shamliyan Tatyana , Peacock Zachary S. , Dorafshar Amir H. 
Published: July 2021

Purpose:
To critically examine reported data to compare patient outcomes between load-sharing and load-bearing plate fixation for edentulous mandibular fractures.

Materials and Methods:
A systematic review and meta-analysis were designed to test the null hypothesis of no difference in postoperative outcomes between load-sharing and load-bearing plate fixation in atrophic, edentulous mandibular fractures. The PubMed, EMBASE, Cochrane Library, Elsevier text mining tool database, and clinicaltrials.gov trial registries were queried up until July 2016. The quality of evidence was determined using the Grading of Recommendations Assessment, Development, and Evaluation method.

Results:
A total of 1212 studies were screened for inclusion of which we included 1 high-quality Cochrane review, 6 narrative reviews, and 21 publications of case reports and case series. Overall, the quality of evidence was low. No difference was found between load-bearing and load-sharing fixation in functional recovery, nonunion, or infection. An uncontrolled case series portrayed complete functional and morphological restoration in 96.9% of patients (83.2–99.5; 95% confidence interval) in load-bearing osteosynthesis while another demonstrated the same outcome in only 40.0% of patients (17.5–65.0; 95% confidence interval).

Conclusions:
The authors did not find a statistically significant difference between load-bearing and load-sharing plate fixation in edentulous atrophic mandibular fracture patients; although this finding may be influenced by type 2 statistical error. Surgeons should continue to use their best clinical judgment in deciding on treatment approach for these challenging fractures. Future studies with higher level evidence are necessary to guide optimal fracture management.
Velopharyngeal Insufficiency in Craniofacial Microsomia: Prevalence, Diagnosis, and Treatment
Authors: Chan Candace H. , Hu Allison C. , Jain Nirbhay S. , Dang Brian N. , Liu Mengyuan T. , Bertrand Anthony A. , Wilson Libby F. , Lee Justine C. 
Published: July 2021

Abstract
The purpose of this study was to analyze the prevalence, diagnosis, and management of velopharyngeal insufficiency (VPI) in patients with craniofacial microsomia (CFM).
Craniofacial microsomia patients 13 years of age and above treated at 2 centers from 1997 to 2019 were reviewed retrospectively for demographics, prevalence of VPI, and management of VPI. Patients with isolated microtia were excluded. Comparisons were made between patients with and without VPI using chi-square and independent samples t tests.
Among 68 patients with CFM (63.2% male, mean 20.7 years of age), VPI was diagnosed in 19 patients (27.9%) at an average age of 7.2 years old. Among the total cohort, 61 patients had isolated CFM, of which 12 (19.6%) were diagnosed with VPI. Of the patients with isolated CFM and VPI, 8 patients (66.7%) were recommended for nasoendoscopy, of which only 2 patients completed. Seven isolated CFM patients (58.3%) underwent speech therapy, whereas none received VPI surgery. In contrast, 7 patients were diagnosed with both CFM and cleft lip and/or palate (CL/P), all of whom had VPI and were recommended for nasoendoscopy, with 5 (71.4%) completing nasoendoscopy, 6 (85.7%) undergoing speech therapy, and 6 (85.7%) undergoing corrective VPI surgery. Overall, we demonstrated that VPI was present in 27.9% of all CFM patients. On subset analysis, VPI was diagnosed in 20% of patients with isolated CFM and 100% of patients with CFM and CL/P. In addition, despite clinical diagnosis of VPI, a sizeable proportion of isolated CFM patients did not undergo therapy or surgical interventions.
The Second Free Tissue Transfer After the First Free Flap Loss for a Complex Scalp Reconstruction: Our Strategy to Success With a Staged Approach
Authors: Song Ping , Jaiswal Rohit , Pu Lee L.Q. 
Published: July 2021

Abstract
Scalp reconstruction for a critical neurosurgical patient, as lifesaving efforts continued, can be challenging and a free tissue transfer is often needed to achieve reliable soft tissue coverage. However, the patient's labile perioperative condition may compromise successful reconstruction and perioperative hypotension is one of the major known factors for the failure of free tissue transfer. In this report, the authors encountered such an instance, and present our strategy in overcoming this hurdle toward obtaining successful scalp reconstruction with second free tissue transfer after the first free flap loss. After optimizing the patient's medical condition, the second free tissue transfer was performed in 2 stages with recipient vessel dissection during the first stage and the flap harvest and microvascular anastomoses during the second stage. Our staged approach is warranted to ensure the patient can tolerate the stressor of general anesthesia and to precondition the patient for ultimate successful second free tissue transfer.
Suturectomies Assisted by Cranial Orthosis Remodeling for the Treatment of Craniosynostosis Can Be Performed Without an Endoscope
Authors: Olshinka Asaf , Har-Shai Lior , Novitski Ivan , Lev Sapir , Ad-El Dean D. , Kershenovich Amir 
Published: July 2021

Background:
Minimally-invasive endoscopic strip-craniectomy (or suturectomy) for the repair of craniosynostosis combined with postoperative cranial orthotic molding has been widely adopted in the past 2 decades, proving itself as a safe and effective procedure. Over time the authors transitioned from performing an endoscopic strip-craniectomy, to performing the same surgery without the endoscope. The authors here describe our technique and compare its results to those published in the literature for endoscopic suturectomies.

Methods:
A retrospective chart review was performed for patients with nonsyndromic craniosynostosis who underwent minimally-invasive nonendoscopic suturectomy between 2019 and 2020 at our institution.

Results:
Thirteen patients (11 males; 2 females) were operated including 5 Metopic, 5 Sagittal, 2 coronal, and 1 lambdoid craniosynostosis. The average age at surgery was 4.35 months. The average length of surgery was 71 minutes. Averaged intraoperative estimated blood loss was 31.54 mL. Eleven patients received a blood transfusion (most before performing the skin incision) with a mean amount of 94.62 mL of blood transfused during surgery. The mean hemoglobin at discharge was 10.38 mg/dL. There was only 1 intraoperative mild complication. The mean intrahospital length of stay was 1.77 days with no postoperative complications noted. All patients initiated remodeling orthotic treatment following surgery. Long-term follow-up scans were available for 8 patients (5 metopic, 2 sagittal, and 1 lambdoid) with an average follow-up of 9 months. In all cases, there was a significant improvement in the skull width at the synostosis location as well as in the skull proportions and symmetry. The above outcomes are similar to those published in the literature for endoscope-assisted strip-craniectomies.

Conclusions:
Suturectomies assisted with cranial orthosis remodeling for the treatment of all types of nonsyndromic craniosynostosis can be performed without an endoscope while maintaining minimal-invasiveness, good surgical results, and low complication rates.
#facialtraumasurgery: Educational Content of Instagram as a Social Media Source for Facial Trauma Surgery
Authors: Lentzen Max-Philipp , Trojtza Sonja , Zinser Max , Kreppel Matthias , Zoeller Joachim E. , Zirk Matthias 
Published: July 2021

Abstract
With an uprising influence of social media platforms like Instagram during the last decade, medical and healthcare related posts have accumulated majorly. In particular the head and face characterizes and signifies each individual's human character, which may be the reason why numerous posts are shared on social media platforms. The purpose of this investigation was to assess the content associated with facial trauma surgery and evaluate its educational quality.
The authors performed a retrospective investigation on 550 Instagram posts by #facialtraumasurgery due to number of “likes,” comments, type of post, language, its purpose, and source. Furthermore, posts were evaluated due to their educational quality by 3 examiners of different educational levels.
The majority of posts showed 0 to 50 “likes” and 0 to 5 comments in English language. The major post type were single photographs (289; 52.5%), multiple photographs (188; 34.2%), videos (73; 13.3%) and predominantly case reports (233; 42.4%). The source was 322 (58.5%) posts by surgeons, followed by 185 (33.6%) clinic posts. Only 10% to 18% of the posts were rated “excellent.” Interrater reliability between all 3 examiners presented a high concordance with 89% (P = 0.000).
Our study presents an analysis of quantity and quality of social media content according to facial trauma surgery. It supports the deduction that most of the content on Instagram is shared by patients and unclear sources and thus is limited informative. Nevertheless, influence of social media on medical information is increasing and practitioners have to face its effect on their patients.
Out of “Site”: Low Utilization of the American Urogynecologic Society’s Online Patient Resources in an Observational Study Using Website Analytics
Authors: Bennett Alaina T. , Gregory W. Thomas , Boniface Emily R. , Cichowski Sara B. 
Published: July 2021

Objectives
The aims of the study were to estimate utilization of the American Urogynecologic Society’s patient education website, VoicesForPFD.org, by women with pelvic floor disorders (PFDs), to describe users over time and how they found the site, and to evaluate use of content areas of the site.

Methods
Website metrics were extracted from Google Analytics during 2013-2019 for VoicesForPFD.org. Data included number and geography of users, source of user arrival (for example search engine, social media, advertisement), and web pages viewed. Utilization was calculated by dividing the number of website users by the estimated number of women with symptomatic PFDs in the same year from previously published prevalence estimates and U.S. Census population data. The number of page views were extracted for each web page from 2017 to 2019 to describe content use. Descriptive analyses are presented.

Results

VoicesForPFD.org had 1,382,287 users during 2013–2019, predominantly in the United States. Nationally, there were 5.3 VoicesForPFD.org users for every 1,000 women with symptomatic PFDs in 2018. Users arrived primarily through organic search and advertisements; less than 1% of users arrived via social media. The pelvic organ prolapse section of VoicesForPFD.org was the most highly viewed content with 670,550 page views in 2017–2019. In the same years, the site’s pages on pelvic mesh had only 21,249 page views despite high media visibility on the subject.

Conclusions
Utilization of VoicesForPFD.org by U.S. women with symptomatic PFDs is very low. More research is needed on methods to engage women online and through social media to provide them with high-quality PFD treatment information.
Risk Factors for Urinary Retention After Colpocleisis
Authors: DiCarlo-Meacham Angela , Dengler Katherine , Welch Eva , Hamade Sara , Horbach Nicolette , Welgoss Jeffrey , Mazloomdoost Donna , Sheridan Michael , von Pechmann Walter 
Published: July 2021

Objectives
Transient urinary retention occurs frequently after pelvic organ prolapse surgery. While the prevalence of postoperative urinary retention has been reported for reconstructive procedures, a paucity of data exists for colpocleisis. The objectives of this retrospective cohort study were to identify risk factors for transient urinary retention after colpocleisis and to determine the rate of its occurrence.

Methods
A retrospective chart review was performed for patients undergoing colpocleisis from January 2015 to December 2019 in a high-volume urogynecology practice. Patients were excluded if they required prolonged catheterization postoperatively because of a surgical complication or used a catheter before surgery, or if a suprapubic catheter was placed during surgery. Potential patient and procedural risk factors were analyzed. Transient urinary retention was diagnosed if patients failed their postoperative voiding trial and went home with a catheter.

Results
A total of 172 patients met the inclusion criteria. The incidence of transient postoperative urinary retention was 55%, with rates of 36.7% with LeFort colpocleisis, 51.5% with posthysterectomy colpocleisis, and 64.9% with colpocleisis with concomitant hysterectomy. Logistic regression revealed an increased risk of postoperative urinary retention if hysterectomy was performed at the time of colpocleisis (odds ratio, 2.9; confidence interval, 1.23–6.84; P = 0.015). Patient age, prolapse severity, preoperative postvoid residual volume, and concomitant anti-incontinence procedure were not associated with transient postoperative urinary retention.

Conclusions
Transient urinary retention occurs in more than half of patients after colpocleisis. Patients undergoing concomitant hysterectomy have the highest risk of postoperative urinary retention. Surgeons can use this information both for counseling and management decisions for individual patients.
Humoral Response of Renal Transplant Recipients to the BNT162b2 SARS-CoV-2 mRNA Vaccine Using Both RBD IgG and Neutralizing Antibodies
Authors: Hod Tammy , Ben-David Aharon , Olmer Liraz , Levy Itzchak , Ghinea Ronen , Mor Eytan , Lustig Yaniv , Rahav Galia 
Published: July 2021

Background.
Data about SARS-CoV-2 vaccines efficacy in renal transplant recipients (RTR) are lacking.

Methods.
To reveal predictors for humoral response to BNT162b2 vaccine among RTR, patients were divided into positive (N = 42) and negative (N = 78) response groups based on receptor-binding domain (RBD) immunoglobulin G (IgG) ≥1.1 and neutralizing antibodies (NA) ≥16 dilution versus RBD IgG <1.1 or NA <16, respectively. NA were detected using a SARS-CoV-2 pseudo-virus.

Results.
NA were detected in only 42 of 120 (35%) of RTR versus 197 of 202 (97.5%) immunocompetent controls (P < 0.001). NA geometric mean titers in RTR were significantly lower versus the control group {83.7 (95% confidence interval [CI], 50.5-138.8) versus 482 (95% CI, 411-566), P < 0.001}. In a multivariable analysis, mycophenolic acid (MPA) dose and hemoglobin level were found to be independent predictors for antibody response in RTR. A positive response rate of 27% versus 63% was observed in patients on and off MPA, respectively. An increase in MPA dose by 1 mg/kg weight reduced the odds for a positive response by 17% (odds ratio = 0.83; 95% CI, 0.75-0.92; P < 0.001). Geometric mean titers for RBD IgG were significantly reduced as MPA daily dose increased. Hemoglobin blood level <13 g/dL reduced the antibody response by 63% (P = 0.04). Pain at the injection site after the second vaccine dose was significantly higher in the responders versus nonresponders (20.5% versus 5.5%, P = 0.01).

Conclusions.
Only 35% of RTR develop NA to the BNT162b2 mRNA vaccine. MPA is a major suppressor of antibody response in RTR.
Case-control study of neuropsychiatric symptoms following COVID-19 hospitalization in 2 academic health systems
Authors: Castro Victor M. , Rosand Jonathan , Giacino Joseph T. , McCoy Thomas H. , Perlis Roy H. 
Published: July 2021

AbstractNeuropsychiatric symptoms may persist following acute COVID-19 illness, but the extent to which these symptoms are specific to COVID-19 has not been established. We utilized electronic health records across 6 hospitals in Massachusetts to characterize cohorts of individuals discharged following admission for COVID-19 between March 2020 and May 2021, and compared them to individuals hospitalized for other indications during this period. Natural language processing was applied to narrative clinical notes to identify neuropsychiatric symptom domains up to 150 days following hospitalization. Among 6,619 individuals hospitalized for COVID-19 drawn from a total of 42,961 hospital discharges, the most commonly documented symptom domains between 31 and 90 days after initial positive test were fatigue (13.4%), mood and anxiety symptoms (11.2%), and impaired cognition (8.0%). In models adjusted for sociodemographic features and hospital course, none of these were significantly more common among COVID-19 patients; indeed, mood and anxiety symptoms were less frequent (adjusted OR 0.72 95% CI 0.64-0.92). Between 91 and 150 days after positivity, most commonly-detected symptoms were fatigue (10.9%), mood and anxiety symptoms (8.2%), and sleep disruption (6.8%), with impaired cognition in 5.8%. Frequency was again similar among non-COVID-19 post-hospital patients, with mood and anxiety symptoms less common (aOR 0.63, 95% CI 0.52-0.75). Neuropsychiatric symptoms were common up to 150 days after initial hospitalization, but occurred at generally similar rates among individuals hospitalized for other indications during the same period. Post-acute sequelae of COVID-19 thus may benefit from standard if less-specific treatments developed for rehabilitation after hospitalization.FundingR01MH120227, R01MH116270 (Perlis)
The antibody landscapes against Group 1 and 2 influenza virus hemagglutinin following AS03 and MF59 adjuvanted H5N1 vaccination
Authors: Goll Johannes B. , Jain Aarti , Jensen Travis L. , Assis Rafael , Nakajima Rie , Jasinskas Algis , Coughlan Lynda , Cherikh Sami R. , Gelber Casey E. , Huw Davies D. , Meade Philip , Stadlbauer Daniel , Strohmeier Shirin , Krammer Florian , Chen Wilbur H. , Felgner Philip L. 
Published: July 2021

ABSTRACTCurrent seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays. The arrays were designed to reflect both full length and globular head HA proteins derived from 17 influenza A subtypes (H1 to H16 and H18) and influenza B strains. We observed significantly increased strain-specific and broad homo- and hetero-subtypic antibody responses with both AS03 and MF59 adjuvanted vaccination with AS03 achieving a higher titer and breadth of IgG responses relative to MF59. Adjuvanted vaccine was also associated with the elicitation of stalk directed antibody. Finally, we established good correlation of the array antibody responses to H5 antigens with standard hemagglutination inhibition and microneutralization titers.
Comparison of humoral and cellular responses in kidney transplant recipients receiving BNT162b2 and ChAdOx1 SARS-CoV-2 vaccines
Authors: Prendecki Maria , Thomson Tina , Clarke Candice L. , Martin Paul , Gleeson Sarah , De Aguiar Rute Cardoso , Edwards Helena , Mortimer Paige , McIntyre Stacey , Lewis Shanice , Deborah Jaid , Cox Alison , Pickard Graham , Lightstone Liz , Thomas David , McAdoo Stephen P. , Kelleher Peter , Willicombe Michelle ,   in collaboration with the OCTAVE Study Consortium
Published: July 2021

ABSTRACTBackgroundAttenuated immune responses to mRNA SARS-CoV-2 vaccines have been reported in solid organ transplant recipients. Most studies have assessed serological responses alone, and there is limited immunological data on vector-based vaccines in this population. This study compares the immunogenicity of BNT162b2 with ChAdOx1 in a cohort of kidney transplant patients, assessing both serological and cellular responses.Methods920 patients were screened for spike protein antibodies (anti-S) following 2 doses of either BNT162b2 (n=490) or ChAdOx1 (n=430). 106 patients underwent assessment with T-cell ELISpot assays. 65 health care workers were used as a control group.ResultsAnti-S was detected in 569 (61.8%) patients. Seroconversion rates in infection-naïve patients who received BNT162b2 were higher compared with ChAdOx1, at 269/410 (65.6%) and 156/358 (43.6%) respectively, p<0.0001. Anti-S concentrations were higher following BNT162b, 58(7.1-722) BAU/ml, compared with ChAdOx1, 7.1(7.1-39) BAU/ml, p<0.0001. Calcineurin inhibitor monotherapy, vaccination occurring >1st year post-transplant and receiving BNT162b2 was associated with seroconversion.Only 28/106 (26.4%) of patients had detectable T-cell responses. There was no difference in detection between infection-naïve patients who received BNT162b2, 7/40 (17.5%), versus ChAdOx1, 2/39 (5.1%), p=0.15. There was also no difference in patients with prior infection who received BNT162b2, 8/11 (72.7%), compared with ChAdOx1, 11/16 (68.8%), p=0.83.ConclusionsEnhanced humoral responses were seen with BNT162b2 compared with ChAdOx1 in kidney transplant patients. T-cell responses to both vaccines were markedly attenuated. Clinical efficacy data is still required but immunogenicity data suggests weakened responses to both vaccines in transplant patients, with ChAdOx1 less immunogenic compared with BNT162b2.
Student nurses’ views on shift patterns: what do they prefer and why? Results from a Tweetchat
Authors: Dall’Ora Chiara , Sainsbury Jessica , Allen Chris 
Published: July 2021

ABSTRACTAimTo understand student nurses’ views around shift patterns.DesignQualitative studyMethodWe held a Tweetchat in May 2019, where we asked questions around the frequency of 12-hour shifts working on placement; schedule flexibility while on placement; which shift patterns they preferred and why. Data from the Tweetchat were analysed to identify emerging themes and inductively develop a coding frame.ResultsSeventy-three nursing students participated in the Tweetchat. The majority (68%) of respondents reported that they work 12-hour shifts on placements. We identified three main overarching themes: “Achieving a personal equilibrium”; “Meeting the needs of the care environment”, “Factors affecting negotiation capacity”. Data highlighted a conflict for most students, where they preferred 12-hour shifts because of more time off for study, paid work, and leisure, while acknowledging 12-hour shifts had a negative effect on fatigue, exhaustion, and their ability to achieve self-care (i.e. poor diet, no exercise).