bluuebunny/crossref_metadata_2025_split huggingface dataset:
User experiences and perceptions of health wearables: an exploratory study in Cambodia
Authors: Liverani Marco , Ir Por , Wiseman Virginia , Perel Pablo 
Published: September 2021

Abstract
Background
In many low- and middle-income countries (LMICs), health system capacities to address the burden of non-communicable diseases (NCDs) are often inadequate. In these countries, wearable health technologies such as smartbands and smartwatches could be used as part of public health programmes to improve the monitoring, prevention, and control of NCDs. Considering this potential, the purpose of this study was to explore user experiences and perceptions of a health wearable in Cambodia.

Methods
Data collection involved a survey, conducted between November 2019 and January 2020, among different categories of participants (including hypertensive participants, non-hypertensive participants, postgraduate students, and civil servants). All participants were given a sample of a watch-type wearable and advised to use it day and night. One month after product delivery, we conducted a survey to explore their views and experiences. Results were analysed by using descriptive statistics and Chi square or Fisher's exact test to compare responses from urban and rural participants.

Results
A total of 156 adult participants completed the study. Technology acceptance was positive overall. 89.1% of the participants said they would continue using the watch and 76.9% of them would recommend it to either friends or relatives, while 94% said the device stimulated them to think more frequently about their health. However, challenges to technology adoption were also identified, including concerns with the accuracy and quality of the device and unfamiliarity with the concept of health self-monitoring, especially among the elderly. Short battery life and cost were also identified as potential barriers to continued use.

Conclusions
Health wearables are a promising new technology that could be used in Cambodia and in other LMICs to strengthen health sector responses to the challenges of NCDs. However, this technology should be carefully adapted to the local context and the needs of less resourced population groups. In addition, further studies should examine if adequate health sector support and infrastructure are in place to implement and sustain the technology.
Synthesis, characterization and stress-testing of a robust quillaja saponin stabilized oil-in-water phytocannabinoid nanoemulsion
Authors: Banerjee Abhinandan , Binder Justin , Salama Rayan , Trant John F. 
Published: September 2021

Abstract
Background
This study describes the design, optimization, and stress-testing of a novel phytocannabinoid nanoemulsion generated using high-pressure homogenization. $\text {QNaturale}^{\circledR }$

QNaturale

Ⓡ

, a plant-derived commercial emulsifier containing quillaja saponin, was used to stabilize the lipid phase droplets in water. Stress-testing was performed on this nanoemulsion in order to evaluate its chemical and colloidal stability under the influence of different environmental factors, encompassing both physical and chemical stressors.

Methods
Extensive optimization studies were conducted to arrive at an ideal nanoemulsion formulation. A coarse emulsion containing 16.6 wt% CBD-enriched cannabis distillate and 83.4 wt% carrier (soybean) oil dispersed in 10 wt% $\text {QNaturale}^{\circledR }$

QNaturale

Ⓡ

(1.5 wt% quillaja saponin) solution after 10 homogenization cycles at a pressure of 30,000 psi produced a stable nanoemulsion. This nanoemulsion was then subjected to the stress studies.

Results
The optimized nanoemulsion had an average droplet diameter of ca. 120 nm and average droplet surface ζ potentials of ca. -30 mV. It was imaged and characterized by a variety of protocols. It proved to be stable to droplet agglomeration and phase separation upon storage under ambient conditions for 6 weeks, as well as under a variety of physical stressors such as heat, cold, dilution, and carbonation. pH values ≤2 and moderately high salt concentrations (> 100 mM), however, destabilized the nanoemulsion, eventually leading to phase separation. Cannabis potency, determined by HPLC, was detrimentally affected by any changes in the nanoemulsion phase stability.

Conclusions
Quillaja saponin stabilized cannabidiol(CBD)-enriched nanoemulsions are stable, robust systems even at low emulsifier concentrations, and are therefore significant from both a scientific as well as a commercial perspective.
De-implementation and substitution of clinical care processes: stakeholder perspectives on the transition to primary human papillomavirus (HPV) testing for cervical cancer screening
Authors: Hahn Erin E. , Munoz-Plaza Corrine , Altman Danielle E. , Hsu Chunyi , Cannizzaro Nancy T. , Ngo-Metzger Quyen , Wride Patricia , Gould Michael K. , Mittman Brian S. , Hodeib Melissa , Tewari Krishnansu S. , Ajamian Lena H. , Eskander Ramez N. , Tewari Devansu , Chao Chun R. 
Published: September 2021

Abstract
Background
New cervical cancer screening guidelines recommend primary human papillomavirus (HPV) testing for women age 30–65 years. Healthcare organizations are preparing to de-implement the previous recommended strategies of Pap testing or co-testing (Pap plus HPV test) and substitute primary HPV testing. However, there may be significant challenges to the replacement of this entrenched clinical practice, even with an evidence-based substitution. We sought to identify stakeholder-perceived barriers and facilitators to this substitution within a large healthcare system, Kaiser Permanente Southern California.

Methods
We conducted semi-structured qualitative interviews with clinician, administrative, and patient stakeholders regarding (a) acceptability and feasibility of the planned substitution; (b) perceptions of barriers and facilitators, with an emphasis on those related to the de-implementation/implementation cycle of substitution; and (c) perceived readiness to change. Our interview guide was informed by the Consolidated Framework for Implementation Research (CFIR). Using a team coding approach, we developed an initial coding structure refined during iterative analysis; the data were subsequently organized thematically into domains, key themes, and sub-themes using thematic analysis, followed by framework analysis informed by CFIR.

Results
We conducted 23 interviews: 5 patient and 18 clinical/administrative. Clinicians perceived that patients feel more tests equals better care, and clinicians and patients expressed fear of missed cancers (“…it’ll be more challenging convincing the patient that only one test is…good enough to detect cancer.”). Patients perceived practice changes resulting in “less care” are driven by the desire to cut costs. In contrast, clinicians/administrators viewed changing from two tests to one as acceptable and a workflow efficiency (“…It’s very easy and half the work.”). Stakeholder-recommended strategies included focusing on the increased efficacy of primary HPV testing and developing clinician talking points incorporating national guidelines to assuage “cost-cutting” fears.

Conclusions
Substitution to replace an entrenched clinical practice is complex. Leveraging available facilitators is key to ease the process for clinical and administrative stakeholders—e.g., emphasizing the efficiency of going from two tests to one. Identifying and addressing clinician and patient fears regarding cost-cutting and perceived poorer quality of care is critical for substitution. Multicomponent and multilevel strategies for engagement and education will be required.

Trial registration
ClinicalTrials.gov, #NCT04371887
Preserving Holocaust history: Geophysical investigations at the Ponary (Paneriai) extermination site
Authors: McClymont Alastair F. , Bauman Paul D. , Freund Richard A. , Seligman Jon , Jol Harry M. , Reeder Philip , Bensimon Ken , Vengalis Rokas 
Published: September 2021

Holocaust mass grave sites in eastern Europe can be difficult to investigate due to a paucity of historical documentation relating to the events and because the use of traditional invasive archaeology methods raises concerns around the disturbance of the remains of Jewish people. When combined with other lines of evidence, including historic photos and eyewitness testimony, noninvasive geophysical methods help to effectively identify and demarcate buried features at Holocaust sites, limiting unnecessary excavations. Between 1941 and 1944, as many as 100,000 people were murdered at the Ponary (Paneriai) extermination site in Lithuania, but many critical details of the site layout during this period are still to be resolved, including the location of some of the mass graves and confirmation of an escape tunnel that was used by slave laborers to escape captivity and certain death at the site. At Ponary, a combination of electrical resistivity tomography (ERT) profiling, limited ground-penetrating radar data, and bare-earth elevation data (from a light and distance ranging data set) was used to confirm the location of a large unmarked mass grave with a diameter of approximately 25 m and depth of approximately 4 m. Additional ERT profiling at a second location imaged the entrance to an escape tunnel previously uncovered by an archaeological excavation in 2004, and it detected an approximately 5 m section of the continuation of the tunnel, approximately 33 m away from the tunnel entrance. The geophysical results are supported by evidence from limited archaeological excavations, historical photographs, eyewitness descriptions of the site layout, and testimonies from the few survivors who managed to escape Ponary.
Hypoadrenalism as the Single Presentation of Autoimmune Polyglandular Syndrome Type 1
Authors: Nasser Nadim H , Samra Nadra G , Naccache Deeb D 
Published: September 2021

Abstract
Type 1 autoimmune polyglandular syndrome (APS1) is a rare hereditary disease affecting nearly 600 patients worldwide. The first of its cardinal manifestations, chronic mucocutaneous candidiasis, hypoparathyroidism, or Addison’s disease, presents in childhood. Additional nonclassical landmarks of APS1 continue to develop as late as the fifth decade of life. Two thirds of patients develop the full triad before 25 years of age. Only 20% of patients develop the entire triad simultaneously. Addison’s disease is rarely reported as the first manifestation. According to APS1 classifications, restricted criteria for a single cardinal component, although elements of suspicion are not sufficient to diagnose APS1. This case report is peculiar as hypoadrenalism was the first and only manifestation of APS1 for nearly 3 decades since its diagnosis. Theoretically, exceptions from the protocol of APS1 diagnostic criteria would be recognized as acceptable for diagnosis in the future, when similar case reports of only 1 component of APS1 appear.
Topical ozonated virgin coconut oil improves wound healing and increases HSP90α, VEGF-A, EGF, bFGF, and CD34 in diabetic ulcer mouse model of wound healing
Authors: Yuniati Renni , Subchan Prasetyowati , Riawan Wibi , Khrisna Matthew Brian , Restiwijaya Maryam , Dyan Kusumaningrum Niken Safitri , Nur Muhammad 
Published: September 2021

Background: Diabetes is a disease that affects people worldwide, including in Indonesia. The prevalence of diabetes in Indonesia is increasing from year to year. One of the most devastating complications of diabetes mellitus is diabetic ulcers, which is a limb-threatening complication. Over the past few decades, ozone generated using plasma medical technology has been investigated as an agent that helps wound healing. This study aims to evaluate the effects of topical ozonated virgin coconut oil (VCO) in a diabetic wound mouse model. Methods: This study was an experimental study with a post-test control design. An ulcer wound model was made in 50 diabetic male Wistar mice, divided into five groups, and a control group of 10 non-diabetic mice. The control groups were given conventional therapy only and the treatment groups were also given topical ozonated VCO with different flow durations (0 min, 90 min, 7 h, 14 h). Macroscopic appearance and wound contraction were observed. HSP90β, VEGF-A, EGF, bFGF, and CD34 levels were measured from the immunostained slices of wound margins. Results: The reduction of wound length was proportionally related to the duration of ozone flow. Ozonated VCO with a longer duration of ozone flow healed the wound more quickly and had the shortest wound length. VCO with ozone flow for 14 hours (16837.10 µm) had the biggest reduction in wound length compared to other groups. The wounds treated with ozonated VCO showed an increase in HSP90β, VEGF-A, EGF, bFGF, and CD34 levels that correlated to improved wound healing. A longer period of treatment resulted in higher levels of wound healing biomarkers compared to shorter therapeutic durations. Conclusions: Topical ozonated VCO improved the wound healing process in a diabetic ulcer mouse model by improving macroscopic wound appearance and increasing levels of wound healing biomarkers.
University-Industry R&D Alliances – An Exploration of Alliance Capabilities Measures
Authors: Kamaruzaman Nabilah , Asmawi Arnifa , Chew Kok Wai 
Published: September 2021

Background: Alliance capabilities studies have long emerged since the 1990s, focusing mainly on firm-to-firm collaboration. However, research on university-industry alliances only emerged from the 2000s. Alliance capabilities are portrayed as a crucial condition to achieve the targeted collaboration outcomes and sustainable relationships. As most alliance capabilities studies focus on firm-to-firm collaboration, research on university-industry research and development (R&D) alliance is still scarce. Thus, the measurement items for alliance capabilities in the university-industry R&D context are still under-developed. Thus, to investigate how alliance capabilities affect university-industry R&D performance in Malaysia, the relevant measures must first be defined. This paper intends to properly define the measurement items for alliance capabilities in the context of university-industry R&D alliances. Methodology: The alliance capabilities measures are adapted from various literature to accommodate both university and industry perspectives. In finalizing the measurement, in-depth pre-testing was conducted by five strategic management subject matter experts in ensuring face and content validity. Results: There are three alliance capability dimensions. The first dimension is alliance management capability which includes goal setting, process configuration, alliance structure, coordination, management support, and alliance evaluation. The second dimension is alliance integration capability which incorporates relational capabilities, inter-organizational communication, relational capital, and project team effectiveness. The third is alliance learning capability which measures alliance experience, knowledge articulation, knowledge sharing, knowledge codification, internalization, and relationship learning. Although this study successfully develops a set of measurement items for alliance capabilities in university-industry R&D, further statistical analysis is required to test this scale. Conclusion: To date, quantitative measurement items for alliance capabilities in the context of university-industry R&D alliances are still at the infancy stage. Although the measurements are yet to be statistically analyzed, they can be used as a benchmark for future university-industry R&D alliances studies.
Children as innovators: harnessing the creative expertise of children to address practical and psychosocial challenges of the coronavirus disease 2019 (COVID-19) pandemic – COVISION study protocol
Authors: McAneney Helen , Shier Harry , Gibbs Lisa , Davies Carmel , De Brún Aoife , Tisdall Kay M. , Corrigan Carmel , Kelly Ayrton , Owens Jacinta , Okoli Onyinye , Wall Tracey , Alves Hayda , Kongats Krystyna , Krishna Revathi N. , Sheppard-LeMoine Debbie , Wagner Fernando A. , Wang Jieh-Jiuh , Mutch Carol , Kroll Thilo , Somanadhan Suja 
Published: September 2021

Background:We are currently in a period of transition, from the pre-COVID-19 (coronavirus disease 2019) era and the initial reactive lockdowns, to now the ongoing living with and potentially the after COVID-19 period. Each country is at its own individual stage of this transition, but many have gone through a period of feeling adrift; disconnected from normal lives, habits and routines, finding oneself betwixt and between stages, similar to that of liminality. Children and young people have been particularly affected.Aim:To increase the understanding of home and community-based strategies that contribute to children and young people’s capacity to adjust to societal changes, both during and after pandemics. Moreover, to identify ways in which children’s actions contribute to the capacity of others to adjust to the changes arising from the pandemic. The potential for these activities to influence and contribute to broader social mobilisation will be examined and promoted.Research design:To achieve the aim of this study, a participatory health research approach will be taken. The overarching theoretical framework of the COVISION study is that of liminality. The study design includes four work packages: two syntheses of literature (a rapid realist review and scoping review) to gain an overview of the emerging international context of evidence of psychosocial mitigations and community resilience in pandemics, and more specifically COVID-19; qualitative explorationof children and young people’s perspective of COVID-19viacreative outlets and reflections; and participatory learning and action through co-production.
Sedentary behaviour levels in adults with an intellectual disability: a systematic review and meta-analysis
Authors: Lynch Louise , McCarron Mary , McCallion Philip , Burke Eilish 
Published: September 2021

Background: Sedentary behaviour (SB), which is characterised by low levels of energy expenditure, has been linked to increased cardio-metabolic risks, obesity and mortality, as well as cancer risk. No firm guidelines are established on safe levels of SB. Adults with an intellectual disability (ID) have poorer health than their counterparts in the general population with higher rates of multi-morbidity, inactivity, and obesity. The reasons for this health disparity are unclear however it is known that SB and overall inactivity contribute to poorer health. There is no clear picture of the levels of SB among individuals with ID therefore SB levels in this vulnerable population need to be examined. The aim of this systematic review is to investigate the prevalence of sedentary behaviour in adults with an ID. Methods: The PRISMA-P framework was applied to identify high quality articles. An extensive search was carried out in four databases and grey literature sources . In total, 1,972 articles were retrieved of which 48 articles went forward for full review after duplicate removal and screening by title and abstract. The National Institute of Health’s quality assessment tools were used to assess article quality. Two reviewers independently assessed each article. An excel spreadsheet was created to guide the data extraction process. The final review included 25 articles. A meta-analysis was completed using REVMAN. Results: Different SB assessment types were identified in studies. These included steps, time, questionnaires, and screen time. Studies were heterogeneous. Observed daily steps per individual ranged from 44 to above 30,000, with an average of approximately 6,500 steps. Mean daily time spent in SBs was more than 60% of available time, with observed screen time of more than 3 hours. Conclusion: There is a high prevalence of SB in adults with an intellectual disability. [Registration no: Index CRD42020177225].
Ethyl lactate production by reactive distillation – optimization of reaction kinetics and energy efficiency
Authors: Stipsitz Peter , Mandl Michael , Harasek Michael 
Published: September 2021

Background: Ethyl lactate is an environmentally benign solvent, which could substitute petrol-based volatile organic compounds (VOCs) in many applications if production costs are reduced. It is usually produced by the esterification of lactic acid with ethanol – two important chemical building blocks of biorefineries that are available at industrial scale. Reactive distillation is a promising alternative production process, which utilises process intensification to increase energy efficiency and space-time yield by enhancing the reaction kinetics. Methods: In this work, process intensification of ethyl lactate production by means of distillation was analysed with special focus on the efficient separation of water. Different setups were evaluated. The feedstock requirements were studied and the process was optimized regarding reaction kinetics in experiments on laboratory level. The preparation of anhydrous starting mixtures for ethyl lactate formation was tested in batch experiments and applied to reactive distillation. The simultaneous distillation was optimized and assessed for its energy efficiency. For this purpose, integrated reactive distillation was compared to a simple setup for distillation enhanced esterification. Results: It was found that an optimized serial setup of reactors and distillation steps can offer similar process intensification at a lower distillate rate compared to simultaneous reactive distillation and is therefore more energy efficient. Moreover, the serial setup is more flexible and straight-forward to regulate and scale-up. Conclusions: Based on the experimental results, the optimal setup and parameters of a continuous process for ethyl lactate production by distillation enhanced esterification was presented.
All-fiber gas Raman laser oscillator
Authors: Li Hao , Huang Wei , Pei Wenxi , Zhou Zhiyue , Cui Yulong , Wang Meng , Wang Zefeng 
Published: September 2021

Here, we report the first, to the best of our knowledge, all-fiber gas Raman laser oscillator (AFGRLO), which is formed by fusion splicing solid-core fibers and a hydrogen-filled hollow-core photonic crystal fiber, and further introducing fiber Bragg gratings at a Stokes wavelength. Pumping with a homemade 1.54 µm fiber amplifier seeded by a narrow linewidth diode laser, we obtain the maximum output Stokes power of 1.8 W at 1693 nm by rotational stimulated Raman scattering of hydrogen molecules. Due to the involvement of the resonant cavity, the measured Raman threshold is as low as 0.98 W, which has been reduced nearly 20 times, compared with that of the single-pass structure. Moreover, a numerical model of an AFGRLO is established for the first time, to the best of our knowledge, and the simulations agree well with the experimental results. This Letter is significant for the development of fiber gas Raman lasers (FGRLs), particularly for achieving compact CW FGRLs towards the mid-infrared.