bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bony Orbital Surgery for Graves' Ophthalmopathy
Authors: Ong Adrian A. , DeVictor Samuel , Vincent Aurora G. , Namin Arya W. , Wang Weitao , Ducic Yadranko 
Published: September 2021

AbstractThe majority of Graves' ophthalmopathy, or thyroid eye disease, can be managed medically; however, in refractory or severe cases, surgical intervention with orbital decompression may be necessary. The majority of the published literature is retrospective in nature, and there is no standardized approach to orbital decompression. The purpose of this review is to evaluate the various surgical approaches and techniques for orbital decompression. Outcomes are ultimately dependent on individual patient factors, surgical approach, and surgeon experience.
The Use of Androgen Priming in Women with Reduced Ovarian Reserve Undergoing Assisted Reproductive Technology
Authors: Richardson Alison , Jayaprakasan Kanna 
Published: September 2021

AbstractAndrogen priming with either dehydroepiandrosterone (DHEA) or testosterone has been suggested as an adjunct to improve in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). Numerous studies have investigated the effects of both DHEA and testosterone on IVF outcome. The results were inconsistent, and the quality of most studies is substandard. Meta-analyses have consistently reported that DHEA does appear to significantly improve IVF outcome in women with predicted or proven poor ovarian response (POR), but these have included some normal responders and/or nonrandomized studies. Our meta-analyses including randomized controlled trials (RCTs) incorporating only women with DOR or POR suggest that DHEA confers no benefit. While meta-analyses of RCTs on the use of testosterone in women with DOR or POR showed an improved IVF outcome, most studies included are of low quality with high risk of bias. When analysis of data from studies of only low-risk bias was performed, such a benefit with testosterone was not observed. Although recruitment may well be a challenge, a large, well-designed RCT is, however, still warranted to investigate whether or not androgen priming with either DHEA or testosterone should be recommended as an adjuvant treatment for women with DOR or POR undergoing IVF.
Social Determinants of Health and Adverse Outcomes in Adolescent Pregnancies
Authors: Amjad S. , Adesunkanmi M. , Twynstra J. , Seabrook J.A. , Ospina M.B. 
Published: September 2021

AbstractThe association between adolescent childbearing and adverse maternal and birth outcomes has been well documented. Adverse adolescent pregnancy outcomes are associated with substantial risk of long-term morbidities for the young mother and their newborns. Multiple levels of social disadvantage have been related to adverse pregnancy outcomes among adolescent mothers. Patterns of cumulative social adversity define the most marginalized group of adolescents at the highest risk of experiencing adverse maternal and birth outcomes. Using a social determinants of health (SDOH) framework, we present an overview of the current scientific evidence on the influence of these conditions on adolescent pregnancy outcomes. Multiple SDOH such as residence in remote areas, low educational attainment, low socioeconomic status, and lack of family and community support have been linked with increased risk of adverse pregnancy outcomes among adolescents. Based on the PROGRESS-Plus equity framework, this review highlights some SDOH aspects that perinatal health researchers, clinicians, and policy makers should consider in the context of adolescent pregnancies. There is a need to acknowledge the intersectional nature of multiple SDOH when formulating clinical and societal interventions to address the needs of the most marginalized adolescent in this critical period of life.
Sign-changing solutions for a kind of Klein–Gordon–Maxwell system
Authors: Zhang Qi 
Published: September 2021

In this paper, the subcritical Klein–Gordon–Maxwell system −Δu + V(x)u − (2ω + ϕ)ϕu = f(u) coupled with Δϕ=(ω+ϕ)u2,x∈R3 is studied. Under general assumptions on V, f, by using the abstract critical theorems, which are derived from the minimax method and the method of invariant sets of descending flow, we obtain the existence of sign-changing solutions for this system, in particular, a sequence of high energy sign-changing solutions is obtained if f is odd.
Design and optimization of scanning magnets for HUST-PTF
Authors: Chen Taiyan , Zuo Chen , Zhou Zijian , Yuan Jushigang , Zou Jiabao , Yao Qinggao , Huang Jiang 
Published: September 2021

We report scanning magnets manufactured at the Huazhong University of Science and Technology Proton Therapy Facility for use in pencil-beam nozzles in a fixed beamline. Such nozzles allow us to control the trajectory of proton beams to form the requisite radiation field for tumor therapy. Two AC-excited scanning magnets operate at a maximum frequency of 100 and 50 Hz, respectively, generating significant eddy currents that raise the temperature. We use transient electromagnetic analysis and thermal analysis to study the eddy current effect and control the temperature. In this paper, the maximum temperature rise of the scanning magnets is taken as the criterion to find the appropriate depth, shape, and distribution of slits. After the slits are optimized, the temperature rise of the scanning magnet is significantly reduced. Finally, the results of DC performance tests satisfy the requirements of the magnetic field.
Mobile apps as language-learning tools
Authors: Sviķe Silga 
Published: September 2021

Abstract
This contribution researches various translation dictionaries – mobile apps with Latvian that are available for
free on the Google Play Store and sets out the experience of developing specialised translation dictionaries at Ventspils
University of Applied Sciences (VUAS). The results encounter three different dictionary models that are compiled for the
acquisition of Languages for Special Purposes (LSPs) to support vocabulary (term) learning, translation, reading, listening and
writing skills during the foreign language-learning process. Dictionaries with grammatical information and rich, supportive data
or encyclopaedic information added are more useful for understanding specific domain concepts and content, as well as for the
translation practice. Thus, the dictionary user does not have to look for another application or other source to get this
additional information. Each new app takes up some space on the user’s smart device; therefore, it is important to maximise the
support provided by a single dictionary. The research provides insight into the range of dictionaries with Latvian available on
the Google Play Store, gives a brief description, and explains the practical experience of VUAS when working on developing such
dictionaries and applying them for language-learning purposes and specialised terminology courses for students. The study also
provides an overview of challenges, problems and lexicographic and information technology solutions for mobile applications. The
goal of the research is analysing and characterising those free-of-charge dictionaries in the form of mobile apps with Latvian as
one of the translation languages. Surveys were used to gather and analyse research data. A survey of dictionary users and a survey
of language learners using dictionary apps were carried out after the development of the specialised dictionaries.
Cost-effective, vision-based multi-target tracking approach for structural health monitoring
Authors: Wu Tong , Tang Liang , Shao Shuai , Zhang Xiang-Yu , Liu Yi-Jun , Zhou Zhi-Xiang 
Published: September 2021

Abstract
The displacement response of structures is an important parameter in structural health monitoring (SHM). Displacement responses can be applied in both structural performance monitoring and structural dynamic characteristics monitoring. To overcome the shortcomings of traditional contact sensors, a vision-based multi-point structural displacement measurement system equipped with an inexpensive surveillance camera and a consumer camera was developed herein. In addition, to reduce the computing time of target tracking, an improved region-matching algorithm based on the prior knowledge of structural deformation was proposed. Numerical results revealed that the improved region-matching algorithm could save computing time without reducing location accuracy. Moreover, static and dynamic loading tests were conducted on a scale model of a suspension bridge to validate the effectiveness of the proposed vision-based measurement system. Displacement responses and modal parameters obtained from the vision-based measurement system were compared with those of traditional contact sensors, and a satisfactory consistency was obtained. Hence, the proposed vision-based measurement system could be a cost-effective alternative to conventional displacement sensors and accelerometers for SHM.
We Fed Them Tales: The Print Culture of Indigenous Dispossession, Folklore, and US Agricultural Modernity in the Writings of Fabiola Cabeza de Baca
Authors: Trujillo Simón Ventura 
Published: September 2021

Abstract
This essay draws from Fabiola Cabeza de Baca’s previously unexamined publication files housed at the University of New Mexico Press to elucidate how US settler regimes of print and crop, upheld by the seizure of Mexican and Indigenous lands, unleashed ecological violence. A noted New Mexican folklorist and teacher, Cabeza de Baca also served as a home economics agent for the US extension service. In the essay’s first section, I trace Cabeza de Baca’s extension writings to demonstrate how US print modernity intersected with devastating ecological transformations sparked by agricultural industrialization. In the following section, I analyze her folkloric work in the context of La Folklórica, a New Mexican Hispanic folkloric society formed in the early twentieth century that amplified the racisms of US modernity while also challenging its claims to agricultural expertise. After tracing Cabeza de Baca’s writings at the juncture of multiple publishing institutions that vied over the value of land and the means of subsistence, I conclude by showing how her folkloric work paradoxically unfolds an ecological praxis that disputes capitalist extraction and centers the vitality of Indigenous knowledge.
Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-β receptor/Smad pathway
Authors: Katayoshi Takeshi , Kusano Yuri , Shibata Takahiro , Uchida Koji , Tsuji-Naito Kentaro 
Published: September 2021

ABSTRACT
Whey proteins (WPs) reportedly enhance cutaneous tissue regeneration in in vivo studies. However, the underlying mechanisms of such regenerative processes are poorly understood. In this study, we show that low-molecular-weight WPs (LMWPs; 1-30 kDa) accelerate the dermal collagen production via the transforming growth factor β receptor (TβR)/Smad pathway. We showed that LMWPs increased type I and III collagen expression in normal human dermal fibroblasts. Moreover, LMWPs rapidly induced Smad protein phosphorylation and nuclear translocation. Notably, type I TβR/Smad signaling inhibitor treatment or type II TβR siRNA knockdown blocked the LMWP-induced type I collagen expression. To identify the active components, we fractionated LMWPs and identified β-lactoglobulin and α-lactalbumin as potential TβR/Smad signaling inducers. Our findings unravel novel biological functions of WPs, involving the TβR/Smad-dependent induction of dermal collagen synthesis, highlighting the therapeutic potential of LMWPs in wound healing.
Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau
Authors: Tsai Hsin-Hsi , Chen Ya-Fang , Yen Ruoh-Fang , Lo Yen-Ling , Yang Kai-Chien , Jeng Jiann-Shing , Tsai Li-Kai , Chang Che-Feng 
Published: September 2021

Abstract
Cerebral small vessel disease is one of the most common causes of cognitive decline and stroke. While several lines of evidence have established a relationship between inflammation and cerebrovascular pathology, the mechanistic link has not yet been elucidated. Recent studies suggest activation of immune mediators, including the soluble form of triggering receptor expressed on myeloid cells 2 (TREM2), may be critical regulators.
In this study, we compared the plasma levels of soluble TREM2 and its correlations with neuroimaging markers and cerebral amyloid load in 10 patients with Alzheimer’s disease and 66 survivors of spontaneous intracerebral haemorrhage with cerebral amyloid angiopathy or hypertensive small vessel disease, two of the most common types of sporadic small vessel disease. We performed brain MRI and 11C-Pittsburgh compound B PET for all participants to evaluate radiological small vessel disease markers and cerebral amyloid burden, and 18F-T807 PET in a subgroup of patients to evaluate cortical tau pathology.
Plasma soluble TREM2 levels were comparable between patients with Alzheimer’s disease and small vessel disease (P = 0.690). In patients with small vessel disease, plasma soluble TREM2 was significantly associated with white matter hyperintensity volume (P &lt; 0.001), but not with cerebral amyloid load. Among patients with Alzheimer’s disease and cerebral amyloid angiopathy, plasma soluble TREM2 was independently associated with a tau-positive scan (P = 0.001) and white matter hyperintensity volume (P = 0.013), but not amyloid load (P = 0.221).
Our results indicate plasma soluble TREM2 is associated with white matter hyperintensity independent of amyloid and tau pathology. These findings highlight the potential utility of plasma soluble TREM2 as a strong predictive marker for small vessel disease-related white matter injury and hold clinical implications for targeting the innate immune response when treating this disease.
Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death
Authors: Walsh Roddy , Adler Arnon , Amin Ahmad S , Abiusi Emanuela , Care Melanie , Bikker Hennie , Amenta Simona , Feilotter Harriet , Nannenberg Eline A , Mazzarotto Francesco , Trevisan Valentina , Garcia John , Hershberger Ray E , Perez Marco V , Sturm Amy C , Ware James S , Zareba Wojciech , Novelli Valeria , Wilde Arthur A M , Gollob Michael H 
Published: September 2021

Abstract

Aims
Catecholaminergic polymorphic ventricular tachycardia (CPVT) and short QT syndrome (SQTS) are inherited arrhythmogenic disorders that can cause sudden death. Numerous genes have been reported to cause these conditions, but evidence supporting these gene–disease relationships varies considerably. To ensure appropriate utilization of genetic information for CPVT and SQTS patients, we applied an evidence-based reappraisal of previously reported genes.

Methods and results
Three teams independently curated all published evidence for 11 CPVT and 9 SQTS implicated genes using the ClinGen gene curation framework. The results were reviewed by a Channelopathy Expert Panel who provided the final classifications. Seven genes had definitive to moderate evidence for disease causation in CPVT, with either autosomal dominant (RYR2, CALM1, CALM2, CALM3) or autosomal recessive (CASQ2, TRDN, TECRL) inheritance. Three of the four disputed genes for CPVT (KCNJ2, PKP2, SCN5A) were deemed by the Expert Panel to be reported for phenotypes that were not representative of CPVT, while reported variants in a fourth gene (ANK2) were too common in the population to be disease-causing. For SQTS, only one gene (KCNH2) was classified as definitive, with three others (KCNQ1, KCNJ2, SLC4A3) having strong to moderate evidence. The majority of genetic evidence for SQTS genes was derived from very few variants (five in KCNJ2, two in KCNH2, one in KCNQ1/SLC4A3).

Conclusions
Seven CPVT and four SQTS genes have valid evidence for disease causation and should be included in genetic testing panels. Additional genes associated with conditions that may mimic clinical features of CPVT/SQTS have potential utility for differential diagnosis.
Integrons, a predictive biomarker for antibiotic resistance in acute sepsis: the IRIS study
Authors: Barraud Olivier , Guichard Elie , Chainier Delphine , Postil Deborah , Chimot Loïc , Mercier Emmanuelle , Frat Jean-Pierre , Desachy Arnaud , Lacherade Jean-Claude , Mathonnet Armelle , Bellec Frédéric , Giraudeau Bruno , Ploy Marie-Cécile , François Bruno ,   the Iris Study Group
Published: September 2021

Abstract

Background
Considering the increase in MDR Gram-negative bacteria (GNB), the choice of empirical antibiotic therapy is challenging. In parallel, use of broad-spectrum antibiotics should be avoided to decrease antibiotic selection pressure. Accordingly, clinicians need rapid diagnostic tools to narrow antibiotic therapy. Class 1–3 integrons, identified by intI1–3 genes, are genetic elements that play a major role in antibiotic resistance in GNB.

Objectives
The objective of the IRIS study was to evaluate the negative and positive predictive values (NPVs and PPVs, respectively) of intI1–3 as markers of antibiotic resistance.

Methods
The IRIS study was an observational cross-sectional multicentre study that enrolled adult subjects with suspected urinary tract or intra-abdominal infections. intI1–3 were detected directly from routinely collected biological samples (blood, urine or intra-abdominal fluid) using real-time PCR. A patient was considered ‘MDR positive’ if at least one GNB, expressing acquired resistance to at least two antibiotic families among β-lactams, aminoglycosides, fluoroquinolones and/or co-trimoxazole, was isolated from at least one biological sample.

Results
Over a 2 year period, 513 subjects were enrolled and 409 had GNB documentation, mostly Enterobacterales. intI1 and/or intI2 were detected in 31.8% of patients and 24.4% of patients were considered ‘MDR positive’. The NPV of intI1 and/or intI2 as a marker of acquired antibiotic resistances was estimated at 92.8% (89.1%–95.5%). The NPVs for first-line antibiotics were all above 92%, notably &gt;96% for resistance to third-generation cephalosporins.

Conclusions
The IRIS study strongly suggests that the absence of intI1 and intI2 in biological samples from patients with GNB-related infections is predictive of the absence of acquired resistances.
The temperature-regulated DEAD-box RNA helicase CrhR interactome: autoregulation and photosynthesis-related transcripts
Authors: Migur Anzhela , Heyl Florian , Fuss Janina , Srikumar Afshan , Huettel Bruno , Steglich Claudia , Prakash Jogadhenu S S , Reinhardt Richard , Backofen Rolf , Owttrim George W , Hess Wolfgang R 
Published: September 2021

Abstract
RNA helicases play crucial roles in RNA biology. In plants, RNA helicases are encoded by large gene families, performing roles in abiotic stress responses, development, the post-transcriptional regulation of gene expression, as well as housekeeping functions. Several of these RNA helicases are targeted to the organelles, the mitochondria and chloroplasts. Cyanobacteria are the direct evolutionary ancestors of plant chloroplasts. The cyanobacterium Synechocystis 6803 encodes a single DEAD-box RNA helicase, CrhR, that is induced by a range of abiotic stresses, including low temperature. Though the ΔcrhR mutant exhibits a severe cold-sensitive phenotype, the physiological function(s) performed by CrhR have not been described. To identify transcripts interacting with CrhR, we performed RNA co-immunoprecipitation with extracts from a Synechocystis crhR deletion mutant expressing the FLAG-tagged native CrhR or a K57A mutated version with an anticipated enhanced RNA binding. The composition of the interactome was strikingly biased towards photosynthesis-associated and redox-controlled transcripts. A transcript highly enriched in all experiments was the crhR mRNA, suggesting an autoregulatory molecular mechanism. The identified interactome explains the described physiological role of CrhR in response to the redox poise of the photosynthetic electron transport chain and characterizes CrhR as an enzyme with a diverse range of transcripts as molecular targets.
Thomas Hunt's Monograms
Authors: Adams Jenny 
Published: September 2021

Abstract
This note expands on an article by Malcolm Parkes, published posthumously in The Library. In his article, Parkes looks at monograms left by Oxford stationer Thomas Hunt in the manuscripts that Hunt appraised. He argues that Hunt capitalized on these manuscripts, using them as securities for borrowed money he in turn invested in his printing business. Thos note shows that Hunt appraised several more books than Parkes found and suggest that Hunt’s work as a university stationer was possibly more lucrative than previously imagined.
A brief supplement to ‘The Marlowe Corpus Revisited’ and Phantom Marlowe
Authors: Ilsemann Hartmut 
Published: September 2021

Abstract
Following the findings of two prior publications this supplement makes use of the General Imposters (GI) method which largely confirms previous results, namely that the Marlowe corpus is stylistically inhomogeneous. The two Tamburlaines match each other in style, but the remaining corpus has hardly any stylistic similarity with them. Instead, there are strong indications of Shakespeare’s involvement in nominal Marlowe plays which becomes most obvious in The Jew of Malta. In terms of methodology, GI turns out to be an additional verification system, at its best when the training set consists of the texts of only two authors.
Advances in constraining intrinsic alignment models with hydrodynamic simulations
Authors: Samuroff S , Mandelbaum R , Blazek J 
Published: September 2021

ABSTRACT
We use galaxies from the illustristng, massiveblack-ii, and illustris-1 hydrodynamic simulations to investigate the behaviour of large scale galaxy intrinsic alignments. Our analysis spans four redshift slices over the approximate range of contemporary lensing surveys z = 0−1. We construct comparable weighted samples from the three simulations, which we then analyse using an alignment model that includes both linear and quadratic alignment contributions. Our data vector includes galaxy–galaxy, galaxy–shape, and shape–shape projected correlations, with the joint covariance matrix estimated analytically. In all of the simulations, we report non-zero IAs at the level of several σ. For a fixed lower mass threshold, we find a relatively strong redshift dependence in all three simulations, with the linear IA amplitude increasing by a factor of ∼2 between redshifts z = 0 and z = 1. We report no significant evidence for non-zero values of the tidal torquing amplitude, A2, in TNG, above statistical uncertainties, although MBII favours a moderately negative A2 ∼ −2. Examining the properties of the TATT model as a function of colour, luminosity and galaxy type (satellite or central), our findings are consistent with the most recent measurements on real data. We also outline a novel method for constraining the TATT model parameters directly from the pixelized tidal field, alongside a proof-of-concept exercise using TNG. This technique is shown to be promising, although comparison with previous results obtained via other methods is non-trivial.