bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Treatment Patterns and Outcomes of Growth Hormone Treatment Among Children in Israel Over the Past Decade (2004–2015)
Authors: Ben-Ari Tal , Chodick Gabriel , Shalev Varda , Goldstein Dalit , Gomez Roy , Landau Zohar 
Published: August 2021

Objective: To assess a decade of growth hormone (GH) treatment patterns and outcomes in a real-world setting in Israel using a state-of-the-art computerized database.Methods: This large retrospective database study included 2,379 children initiating GH treatment in Maccabi Healthcare Services (between January 2004 and December 2014). Good adherence with therapy (proportion of days covered &gt;80%) was assessed during follow-up.Results: At GH treatment initiation: 62.1% were boys; height standard deviation score (SDS) was −2.36 ± 0.65 (mean ± SD); age was 9.8 ± 3.1 years; and time from short stature diagnosis to first GH purchase was 4.8 ± 3.3 years. Mean treatment period was 3.5 ± 0.95 years; 79.4% of children were treated for more than 3 years. The two main indications for GH therapy were idiopathic short stature (ISS) (n = 1,615, 67.9%) and GH deficiency (GHD) (n = 611, 25.7%). Children in the highest socio-economic-status (SES) tertile comprised 61.3% of ISS and 59.7% of GHD. After 3 years, mean height gain SDS was 1.09 ± 0.91 for GHD and 0.96 ± 0.57 for ISS (p = 0.0004). Adult height (age 15 for girls and 17 for boys) was recorded for 624 patients (26.2%) with better outcomes for GHD than ISS (−1.0±0.82 vs. −1.28±0.93, respectively; p = 0.0002). Good adherence was achieved in 78.2% of the cohort during the first year and declined thereafter to 68.1% during the third year of the treatment.Conclusions: Children who initiate GH therapy are predominantly male, belong mainly to the upper SES, commence treatment a long period after initial recognition of short stature, and have suboptimal adherence. Appropriate referral, diagnosis, and follow-up care may result in better treatment outcomes with GH therapy.
The Efficacy and Safety of Rituximab for Childhood Steroid-Dependent Nephrotic Syndrome: A Systematic Review and Meta-Analysis
Authors: Liu Sidi , Gui Chuying , Lu Zhenzhen , Li Huijie , Fu Zhike , Deng Yueyi 
Published: August 2021

Objectives: Rituximab (RTX), a possible alternative treatment option, is recognized as a new therapeutic hope for the treatment of steroid-dependent nephrotic syndrome (SDNS) in children. However, the efficacy and safety of RTX in the treatment of childhood SDNS are still controversial. The objective of this study was to evaluate the efficacy and safety of RTX treatment in children with SDNS.Study Design: Six randomized controlled trials (RCTs) and one retrospective comparative control study data from studies, performed before January 2021 were collected, from PubMed, Cochrane Library, Embase, and Web of Science. The studies evaluating the efficacy and safety of RTX in childhood SDNS were included.Results: Six RCTs and one retrospective comparative control study were included in our analysis. Compared with the control group, the RTX treatment group achieved a higher complete remission rate (OR = 5.21; 95% CI, 3.18–8.54; p &lt; 0.00001), and we found significant differences between the two groups on serum albumin level (MD = 0.88; 95% CI, 0.43–1.33; p = 0.0001) and estimated glomerular filtration rate (MD = 6.43; 95% CI, 2.68–10.19; p = 0.0008). However, RTX treatment did not significantly lower serum creatinine levels nor did it significantly reduce the occurrence of proteinuria. In addition, we found no advantages with RTX on treatment safety.Conclusions: RTX has shown satisfactory characteristics in terms of efficacy and may be a promising treatment method for SDNS in children. However, the long-term effects have not been fully evaluated and should be further studied through randomized clinical trials.
Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models
Authors: Chang Johannes , Meinke Jonathan , Geck Moritz , Hebest Marc , Böhling Nina , Dolscheid-Pommerich Ramona , Stoffel-Wagner Birgit , Kristiansen Glen , Overhaus Marcus , Peyman Leon O. , Klein Sabine , Uschner Frank E. , Brol Maximilian J. , Vilz Tim O. , Lingohr Philipp , Kalff Jörg C. , Jansen Christian , Strassburg Christian P. , Wehner Sven , Trebicka Jonel , Praktiknjo Michael 
Published: August 2021

Background: Liver cirrhosis is a relevant comorbidity with increasing prevalence. Postoperative decompensation and development of complications in patients with cirrhosis remains a frequent clinical problem. Surgery has been discussed as a precipitating event for decompensation and complications of cirrhosis, but the underlying pathomechanisms are still obscure. The aim of this study was to analyze the role of abdominal extrahepatic surgery in cirrhosis on portal pressure and fibrosis in a preclinical model.Methods: Compensated liver cirrhosis was induced using tetrachlormethane (CCL4) inhalation and bile duct ligation (BDL) models in rats, non-cirrhotic portal hypertension by partial portal vein ligation (PPVL). Intestinal manipulation (IM) as a model of extrahepatic abdominal surgery was performed. 2 and 7 days after IM, portal pressure was measured in-vivo. Hydroxyproline measurements, Sirius Red staining and qPCR measurements of the liver were performed for evaluation of fibrosis development and hepatic inflammation. Laboratory parameters of liver function in serum were analyzed.Results: Portal pressure was significantly elevated 2 and 7 days after IM in both models of cirrhosis. In the non-cirrhotic model the trend was the same, while not statistically significant. In both cirrhotic models, IM shows strong effects of decompensation, with significant weight loss, elevation of liver enzymes and hypoalbuminemia. 7 days after IM in the BDL group, Sirius red staining and hydroxyproline levels showed significant progression of fibrosis and significantly elevated mRNA levels of hepatic inflammation compared to the respective control group. A progression of fibrosis was not observed in the CCL4 model.Conclusion: In animal models of cirrhosis with continuous liver injury (BDL), IM increases portal pressure, and development of fibrosis. Perioperative portal pressure and hence inflammation processes may be therapeutic targets to prevent post-operative decompensation in cirrhosis.
Validity and Reliability of the Urdu Version of the McLean Screening Instrument for Borderline Personality Disorder
Authors: Munawar Khadeeja , Aqeel Muhammad , Rehna Tasnim , Shuja Kanwar Hamza , Bakrin Faizah Safina , Choudhry Fahad Riaz 
Published: August 2021

Introduction: Although the translation and the validation of the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD) are performed in various languages and samples, no study has established the validity and reliability of the Urdu version of MSI-BPD in individuals with cardiac problems.Materials and Methods: The Urdu version of the MSI-BPD was prepared through the standard back-translation method. The translation and adaption were completed in four steps: forward translation, adaption and translation, back translation and committee approach, and cross-language validation. The sample, selected through the purposive sampling method, comprised of 150 adults with cardiac problems (men = 75 and women = 75), with an age range of 23–78 years (M = 55, SD = 10.6). The Cronbach alpha reliability and factorial validity of the MSI-BPD were assessed through confirmatory factor analysis (CFA) and Pearson correlation analyses. Internal consistency and test–retest reliability (at 2 weeks' interval) were used to evaluate the reliability. Statistical analyses were performed, using SPSS (version 22) and Structural Equation Modeling (SEM) software.Results: Preliminary analysis revealed that the overall instrument had good internal consistency (Urdu MSI-BPD α = 0.79; English MSI-BPD α = 0.77) as well as test–retest correlation coefficients for 15 days (r = 0.94).Conclusions: Findings suggested that the MSI-BPD, with important limitations, can be used as an effective preliminary screening tool to measure BPD in Urdu-speaking adults with cardiac problems. Further validations should be conducted to make the translated version of the MSI-BPD an appropriate tool to screen BPD in hospitals and mental health care settings.
Validation of the French Version of the Child Posttraumatic Stress Checklist in French School-Aged Children
Authors: Gindt Morgane , Richez Aurelien , Battista Michèle , Fabre Roxane , Thümmler Susanne , Fernandez Arnaud , Askenazy Florence 
Published: August 2021

Background: The child posttraumatic stress disorder checklist (CPC) updated to DSM-5 is a questionnaire aimed to assess posttraumatic stress disorder (PTSD) symptoms in children. It is available in both parents and child versions. The back-translation method has been used for the French translation of the CPC. It has not been yet validated in French-speaking populations. The aim of this study was to assess the psychometric properties and the validity of the CPC in a sample of French-speaking schoolchildren and their parents.Methods: The sample was composed by 176 children outpatients implicated in the Nice terrorist attack (14 July 2016) aged 7–17 (mean = 11.68 years, SD = 2.63 months) and 122 parents. Cronbach's alpha was used to test CPC internal consistency. The Spearman-correlation coefficient was performed between the French version of the CPC and the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime version (K-SADS-PL) to assess the convergent validity. An ROC curve was constructed to verify the validity of the cutoff scores. An evaluation of the sensitivity and specificity of each score and a comparison with the diagnosis of the K-SADS-PL were made. Finally, a principal component analysis with varimax rotation was computed to analyze the structure of the French version of the CPC.Results: Cronbach's alpha coefficient was 0.90 for child version and 0.91 for parent version of the CPC. There was a statistical correlation between the K-SADS-PL for PTSD and the total score of CPC for the child version (r = 0.62; p &lt; 0.001) and for the parent version (r = 0.55; p &lt; 0.001). The sensitivity and specificity of the children version with a threshold of &gt;20 were 73.1 and 84.7%, respectively, using the K-SADS-PL as the diagnostic reference for PTSD. Concerning the parent version, using the same recommended cutoff score, the sensitivity, and specificity were 77 and 80.5%, respectively.Conclusions: The psychometric properties of the French CPC are good. This questionnaire appears to be valid and should be used in French-speaking children.
The European Union and Public Health Emergencies: Expert Opinions on the Management of the First Wave of the COVID-19 Pandemic and Suggestions for Future Emergencies
Authors: Gontariuk Marie , Krafft Thomas , Rehbock Cassandra , Townend David , Van der Auwermeulen Loth , Pilot Eva 
Published: August 2021

Objective: The first wave of the coronavirus SARS-COV-2 pandemic has revealed a fragmented governance within the European Union (EU) to tackle public health emergencies. This qualitative study aims: 1) to understand the current EU position within the field of public health emergencies taking the case of the COVID-19 as an example by comparing and contrasting experiences from EU institutions and experts from various EU Member States at the beginning of the pandemic; and, 2) to identify and to formulate future EU pandemic strategies and actions based on experts' opinions.Methods: Eighteen semi-structured interviews were conducted with public health experts from various European Member States and European Commission officials from May 2020 until August 2020. The transcripts were analyzed by Thematic Content Analysis (TCA), mainly a manifest content analysis.Results: This study demonstrated that the limited EU mandate in health hinders proper actions to prevent and tackle infectious disease outbreaks, such as the COVID-19 pandemic. The results showed that this limitation significantly impacted the ECDC, as the Member States' competence did not allow the agency to have more capacity. The European Commission has fulfilled its role of coordinating and supporting the Member States by facilitating networks and information exchange. However, EU intra- and inter-communication need further improvement. Although diverse EU instruments and mechanisms were found valid, their implementation needed to be faster and more efficient. The results pointed out that underlying political challenges in EU decision-making regarding health emergencies hinder the aligned response. It was stated that the Member States were not prepared, and due to the restriction of their mandate, EU institutions could not enforce binding guidelines. Additionally, the study explored future EU pandemic strategies and actions. Both, EU institutions and national experts suggested similar and clear recommendations regarding the ECDC, the investment, and future harmonized preparedness tools.Conclusion: The complex politics of public health at the EU level have led to the fragmentation of its governance for effective pandemic responses. This ongoing pandemic has shed light on the fragility of the political and structural systems in Europe in public health emergencies. Health should be of high importance in the political agenda, and robust health reforms at the local, regional, national, and EU levels are highly recommended.
Use of X-Ray Fluorescence Microscopy for Studies on Research Models of Hepatocellular Carcinoma
Authors: Paunesku Tatjana , Gordon Andrew C. , White Sarah , Harris Kathleen , Antipova Olga , Maxey Evan , Vogt Stefan , Smith Anthony , Daddario Luiza , Procissi Daniele , Larson Andrew , Woloschak Gayle E. 
Published: August 2021

Introduction: TheraSphere® microspheres containing yttrium 90Y are among many radioembolization agents used clinically to reduce liver tumor burden, and their effects on cancer volume reduction are well-established. At the same time, concerns about off target tissue injury often limit their use. Deeper investigation into tissue distribution and long-term impact of these microspheres could inform us about additional ways to use them in practice.Methods: Healthy rat liver and rabbit liver tumor samples from animals treated with TheraSpheres were sectioned and their elemental maps were generated by X-ray fluorescence microscopy (XFM) at the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory (ANL).Results: Elemental imaging allowed us to identify the presence and distribution of TheraSpheres in animal tissues without the need for additional sample manipulation or staining. Ionizing radiation produced by 90Y radioactive contaminants present in these microspheres makes processing TheraSphere treated samples complex. Accumulation of microspheres in macrophages was observed.Conclusions: This is the first study that used XFM to evaluate the location of microspheres and radionuclides in animal liver and tumor samples introduced through radioembolization. XFM has shown promise in expanding our understanding of radioembolization and could be used for investigation of human patient samples in the future.
Three-Dimensional Water-Based Magneto-Hydrodynamic Rotating Nanofluid Flow over a Linear Extending Sheet and Heat Transport Analysis: A Numerical Approach
Authors: Hussain Azad , Arshad Mubashar , Rehman Aysha , Hassan Ali , Elagan S. K. , Ahmad Hijaz , Ishan Amira 
Published: August 2021

This comparative study inspects the heat transfer characteristics of magnetohydrodynamic (MHD) nanofluid flow. The model employed is a two-phase fluid flow model. Water is utilized as the base fluid, and zinc and titanium oxide (Zn and TiO2) are used as two different types of nanoparticles. The rotation of nanofluid is considered along the z-axis, with velocity ω*. A similarity transformation is used to transform the leading structure of partial differential equations to ordinary differential equations. By using a powerful mathematical BVP-4C technique, numerical results are obtained. This study aims to describe the possessions of different constraints on temperature and velocity for rotating nanofluid with a magnetic effect. The outcomes for the rotating nanofluid flow and heat transference properties for both types of nanoparticles are highlighted with the help of graphs and tables. The impact of physical concentrations such as heat transference rates and coefficients of skin friction are examined. It is noted that rotation increases the heat flux and decreases skin friction. In this comparative study, Zn-water nanofluid was demonstrated to be a worthy heat transporter as compared to TiO2-water nanofluid.
Jornada Exploratória
Authors: Carvalho Amanda Schmidt , Silva Gabriela Prates da , Sousa Rodrigo Silva Caxias de 
Published: August 2021

Analisa as formas de busca e uso de informações de mestres de RPG. A partir do conceito de comportamento informacional, discute o quanto o conceito de imaginário se consagra fundamental na composição das dinâmicas do jogo. Problematiza essas dinâmicas considerando os conceitos de necessidade busca e compartilhamento de informações. A metodologia de cunho qualitativo se estruturou a partir da Técnica de Análise de Conteúdo (BARDIN, 2016) de acordo com o critério semântico dos textos explicitados. As análises permitem afirmar que o processo de criação ocorre fundamentado na ausência de padrões, tendo por referência a conjunção de diferentes aspectos em relação ao do uso de fontes formais e informais associadas à internet. A busca de informações está relacionada a aspectos instrumentais e lógicos do jogo e as motivações elencadas têm como referência a socialização e a colaboração entre os participantes do jogo.
Analisis Perbandingan Financial Distress Pada Perusahaan Sub Sektor Rokok Periode 2015-2019
Authors: Makruf Anang , Ramdani Deni 
Published: August 2021

Abstract – The aim of the study was to analyze financial distress in cigarette companies list in Indonesia Stock Exchange in 2015-2019 using 3 methods, Altman Z-Score, Zmijewski, and Springate. Purposive sampling is used in this study to determine the sampling technique. The sample used in this study released 4 cigarette companies. Descriptive asalysis with quantitative models was used to analyze data in this research. Altman Z-Score, Zmijewski, and Springate in 2015-2019 PT. HM Sampoerna Tbk, PT. Gudang Garam Tbk, and PT. Wismilak Inti Makmur Tbk is related to safe, but it is needed a company that is estimated to be grey in the Altman Z-Score calculation in 2018, PT. Wismilak Inti Makmur Tbk. The Z-score is at the limit because the companie has a ratio with a lower value in market value of equity to book value of liabilities

Abstrak – Penelitian ini memiliki bertujuan untuk menganalisis perbandingan kesulitan keuangan dalam perusahaan sun sektor rokok di Indonesia Stock Exchange periode 2015-2019 menggunakan tiga metode. Metode yang digunakan yaitu Altman Z-Score, Zmijewski, dan Springate. Purposive sampling digunakan dalam penelitian ini untuk menentukan teknik pengambilan sampel. Sampel yang digunakan berjumlah 4 perusahaan rokok. Analisis deskriptif dengan pendekatan kuantitatif digunakan sebagai teknik analisis data. Dalam penelitian ini menjelaskan financial distress yang dihitung menggunakan metode Altman Z-Score, Zmijewski , dan Springate pada tahun 2015-2019 PT. HM Sampoerna Tbk, PT. Gudang Garam Tbk, dan PT. Wismilak Inti Makmur Tbk mengalami dalam kondisi keuangan yang sehat, namun terdapat perusahaan yang diestimasi rawan kebangkrutan pada perhitungan Altman Z-Score pada tahun 2018 yaitu PT. Wismilak Inti Makmur Tbk. hal ini dapat terjadi karena nilai Z-Score PT. Wismilak Inti MakmurTbk berada pada Z < 1,81 salah satu penyebabnya ialah rendahnya rasio market value of equity terhadap liabilities.
Pengaruh Creative Tourist Experience, Travel Motivation dan Perceived Risk Terhadap Revisit Intention Pada Wisata Edukasi Secara Virtual
Authors: Mayasari Novyta Putri , Artanti Yessy 
Published: August 2021

Abstract – The development of the progress of tourism potential is currently increasing with the emergence of tourist changes in attracting tourist. Tourism managers are required to be able to provide tourist comfort to maintain the popularity of tourism even during a pandemic. Some tourism managers during the pandemic offer virtual educational tours. This study aims to analyze the effect of creative tourist experience, travel motivation and perceived risk on revisit intention. This research uses non probability sampling and judgmental sampling method to target respondents. The respondent is someone who was visited the Surabaya Zoo virtually during the Covid-19 pandemic, with a vulnerable age of 13-50 years as many as 200 respondents. The data analysis technique used multiple regression. The results of this study indicate that creative tourist experience and travel motivation have significant effect on revisit intention. Meanwhile, perceived risk has no significant effect on revisit intention.
Abstrak – Perkembangan kemajuan potensi pariwisata saat ini terus meningkat dengan munculnya perubahan-perubahan wisata dalam menarik perhatian wisatawan. Pengelola wisata dituntut dapat memberikan kenyamanan wisatawan untuk mempertahankan popularitas wisata bahkan ketika pada masa pandemi. Beberapa pengelola wisata dimasa pandemi menawarkan wisata edukasi secara virtual. Penelitian ini bertujuan untuk menganalisis pengaruh creative tourist experience, travel motivation dan perceived risk terhadap revisit intention pada wisata edukasi secara virtual. Penelitian ini menggunakan non probability sampling dengan judgment sampling. Responden adalah seseorang yang telah mengunjungi Kebun Binatang Surabaya secara virtual di masa pandemi Covid-19, dengan rentan usia 13-50 tahun sebanyak 200 responden. Teknik analisis data menggunakan regresi berganda. Hasil penelitian ini menunjukkan bahwa creative tourist experience dan travel motivation berpengaruh signifikan terhadap revisit intention. Sedangkan perceived risk tidak berpengaruh signifikan terhadap revisit intention.
RECOMMENDATIONS ON INTEGRATED APPLICATION OF DOPPLER RADAR SYSTEMS OF EXTERNAL TRACTORY MEASUREMENTS IN THE MOBILE TESTING GROUND MEASURING AND COMPUTING COMPLEX
Authors: Lyashenko V. , Kuznecov V. , Kipriianov O. , Yermolenko F. , Pavliuk T. 
Published: August 2021

Testing ground measuring and computing complex (TGMCC) is a set of interconnected hardware and software designed to perform measurements and processing of measuring information to determine the tactical and technical characteristics of objects in different conditions of their application, objective evaluation of test results of armament and military equipment (AME).
For radar measurements of trajectory parameters of moving objects, mobile and stationary radar stations of trajectory measurements are used, including Doppler radar systems of external trajectory measurements. Such radar stations of trajectory measurements are one of the components of TGMCC. They are designed to measure, process and record the parameters of the trajectories of moving objects in a given spatial volume with a given accuracy and reliability during testing of a wide range of new and upgraded samples of AME, as well as perform measurements along with optoelectronic stations of trajectory measurements, or they could be used separately from them.
Therefore, currently there is a problem of creation of mobile testing ground measuring and computing complex which consists in its equipping by modern means of external trajectory measurements, both domestic and foreign.
Thus, the proposed recommendations for the integrated application of Doppler radar systems of external trajectory measurements as a part of a mobile testing ground measuring and computing complex will allow to conduct testing and certification of armament and military equipment offered for supply to the Armed Forces of Ukraine more efficiently and with increased quality.