bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telegenetics for inherited retinal diseases in the COVID-19 environment
Authors: Al-Moujahed Ahmad , Kumar Aarushi , Chemudupati Teja , Tsang Stephen H. , Mahajan Vinit B. 
Published: March 2021

AbstractInherited retinal diseases (IRDs) are visually debilitating conditions that affect families worldwide. They require extensive clinical testing, examination, and patient and family counseling, which are frequently accomplished over single-day extended clinic visits. However, the COVID-19 pandemic has limited the number of patients and staff allowed in clinics, leading to interruptions in care. We therefore developed telehealth management protocols for complete or hybrid virtual visits. The three main components of our telegenetics approach included reviewing the diagnostic tests results remotely, in-person or virtual video visits with a retina specialist, and virtual genetic testing using saliva kits. During the first 5 months of the program, telegenetic care was provided for 80 patients, including 3 international patients, and a spectrum of retinal dystrophies were diagnosed and managed. In conclusion, telegenetic virtual visits ensure continuity of care while reducing patient and provider exposure to SARS-CoV-2 and may continue and expand into other medical genetic conditions long after the pandemic.
Breast edema, from diagnosis to treatment: state of the art
Authors: Verbelen Hanne , Tjalma Wiebren , Dombrecht Dorien , Gebruers Nick 
Published: March 2021

Abstract
Introduction
Breast edema can arise from different etiologies; however, it is mostly seen after breast conserving surgery and/or radiotherapy. Combining breast conserving surgery and radiotherapy can cause damage to the lymphatic system and reactions to surrounding tissues, which can lead to breast edema; hereby, the breast size can increase by more than one cup size. Swelling of the breast is not the only criterion associated with breast edema. Other common criteria found in literature are peau d’orange, heaviness of the breast, skin thickening, breast pain, redness of the skin, hyperpigmented skin pores and a positive pitting sign. Despite the benefits of breast conserving surgery, breast edema can be uncomfortable, and can negatively influence quality of life in suffering patients. In contrast to lymphedema of the arm, which is well known in clinical practice and in research, breast edema is often underestimated and far less explored in literature. Currently, many aspects still need to be reviewed.

Purpose and importance to practice
This masterclass aims at providing the state of the art of breast edema for all health care workers and researchers involved in the treatment and monitoring of breast cancer patients. It includes current and future perspectives on its diagnosis, longitudinal course and treatment. Furthermore, recommendations for clinical practice and future research are discussed.

Clinical implications
It is recommended to closely monitor those patients in whom breast edema symptoms do not decline within 6 months after termination of radiotherapy and provide them with the appropriate therapy. Since evidence concerning the treatment of breast edema is currently lacking, we recommend the complex decongestive therapy (CDT) to the utmost extent, by analogy with the lymphedema treatment of the extremities. This treatment involves skin care, exercise therapy and compression. Additionally, all patients should be informed about the normal course of breast edema development.

Future research priorities
A consensus should be reached among clinicians and researchers concerning the definition, assessment methods and best treatment of breast edema. Furthermore, high quality studies are necessary to prove the effectiveness of the CDT for breast edema.
Explaining persistence in online courses in higher education: a difference-in-differences analysis
Authors: Lakhal Sawsen , Khechine Hager , Mukamurera Joséphine 
Published: March 2021

AbstractThe aim of this study was to verify if the UTAUT model, enriched with anxiety and factors relating to students characteristics and to the specificities of online courses, influences persistence in online courses. A theoretical model encompassing 13 variables was tested. Three moderating variables (gender, age and prior online course experience) were taken into account in the analyses. Data was collected among a sample of 759 students from Université Laval and Université de Sherbrooke using an online questionnaire. The results indicate that the main driver of persistence in online courses are: anxiety, satisfaction, effort expectancy, engagement, behavioral intention, employer encouragement, facilitating conditions and performance expectancy. The structural model was further examined according to gender, age and prior online course experience groups. Findings indicate that the model explains 21.4% to 37.1% of the variance in persistence in online courses. Moreover, as expected, the results indicated different patterns in the strength and significant relationships between groups and for the overall model, suggesting that gender, age and prior online course experience play a moderating role. The discussion links the results of this study to those of previous studies and suggests areas for improvement that could be implemented by academic administrators and instructors in order to enhance persistence in online courses.
Organic matter-driven electrical resistivity of immature lacustrine oil-prone shales
Authors: Jia Jianliang , Zhou Renjie , Liu Zhaojun , Han Xuehui , Gao Yuan 
Published: March 2021

Organic matter (OM) and minerals are major particle components in lacustrine organic-rich shales. Their association and distribution control the development of the primary pore space. The response of OM-driven conduction by modifying the pore-space volume and structure in organic-rich shales of the virgin zone is still unclear. Based on a detailed study of geochemical, mineralogical, and geophysical properties from immature lacustrine oil-prone shales of the Songliao Basin (Northeast China), we have observed a novel continuous variation of electrical resistivity driven by large ranges of total-organic-carbon (TOC) content (0.64–24.51 wt%). The reduced resistivity at low TOC content ([Formula: see text]) and then enhanced resistivity at high TOC content ([Formula: see text]) are present in our immature shales. These variations in electrical resistivity are confirmed by fluid (S1) and solid organic compounds (S2). Furthermore, clay and detrital minerals in shales contribute to the variation of electrical resistivity as well as OMs at low and high TOC content. The electrical resistivity of shales is closely related to the pore-space volume and structure for the electrical flow pathway. Two resistivity trends are highlighted by pore parameters such as the pore volume, throat/pore ratio, pore diameter, and bulk density. Although reduced amounts and the arrangement of large pores for low TOC content cannot decrease the conduction, the enhanced additional clay conduction and low OM concentration reduce the resistivity of shales. Moreover, increased amounts of nonconductive fluid and solid organic compounds and the effect of OM filling on pore space during high TOC content enhance the resistivity of shales. Thus, modified minerals and pore space driven by various OMs affect the electrical resistivity of immature shales. These results improve the understanding of OM-driven conduction in shales and contribute to the evaluation of source rocks using a well-log method.
Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer —Association With Patient and Disease Characteristics and Effect on Prognosis
Authors: Fasching Peter A. , Yadav Siddhartha , Hu Chunling , Wunderle Marius , Häberle Lothar , Hart Steven N. , Rübner Matthias , Polley Eric C. , Lee Kun Y. , Gnanaolivu Rohan D. , Hadji Peyman , Hübner Hanna , Tesch Hans , Ettl Johannes , Overkamp Friedrich , Lux Michael P. , Ekici Arif B. , Volz Bernhard , Uhrig Sabrina , Lüftner Diana , Wallwiener Markus , Müller Volkmar , Belleville Erik , Untch Michael , Kolberg Hans-Christian , Beckmann Matthias W. , Reis André , Hartmann Arndt , Janni Wolfgang , Wimberger Pauline , Taran Florin-Andrei , Fehm Tanja N. , Wallwiener Diethelm , Brucker Sara Y. , Schneeweiss Andreas , Hartkopf Andreas D. , Couch Fergus J. 
Published: March 2021

PURPOSE Among patients with metastatic breast cancer (mBC), the frequency of germline mutations in cancer susceptibility genes and the clinical relevance of these mutations are unclear. In this study, a prospective cohort of patients with mBC was used to determine mutation rates for breast cancer (BC) predisposition genes, to evaluate the clinical characteristics of patients with mutations, and to assess the influence of mutations on patient outcome. PATIENTS AND METHODS Germline DNA from 2,595 patients with mBC enrolled in the prospective PRAEGNANT registry was evaluated for mutations in cancer predisposition genes. The frequencies of mutations in known BC predisposition genes were compared with results from a prospective registry of patients with nonmetastatic BC sequenced using the same QIAseq method and with public reference controls. Associations between mutation status and tumor characteristics, progression-free survival, and overall survival were assessed. RESULTS Germline mutations in 12 established BC predisposition genes (including BRCA1 and BRCA2) were detected in 271 (10.4%) patients. A mutation in BRCA1 or BRCA2 was seen in 129 patients (5.0%). BRCA1 mutation carriers had a higher proportion of brain metastasis (27.1%) compared with nonmutation carriers (12.8%). Mutations were significantly enriched in PRAEGNANT patients with mBC compared with patients with nonmetastatic BC (10.4% v 6.6%, P < .01). Mutations did not significantly modify progression-free survival or overall survival for patients with mBC. CONCLUSION Multigene panel testing may be considered in all patients with mBC because of the high frequency of germline mutations in BRCA1/2 and other BC predisposition genes. Although the prognosis of mutation carriers and nonmutation carriers with mBC was similar, differences observed in tumor characteristics have implications for treatment and for future studies of targeted therapies.
Barriers to Prescribing Targeted Therapies for Patients With NSCLC With Highly Actionable Gene Variants in the Veterans Affairs National Precision Oncology Program
Authors: Vashistha Vishal , Armstrong Jenna , Winski David , Poonnen Pradeep J. , Hintze Bradley , Price Meghan , Snowdon Jane L. , Weeraratne Dilhan , Brotman David , Jackson Gretchen P. , Kelley Michael J. 
Published: March 2021

PURPOSE: Next-generation sequencing (NGS) gene panels are frequently completed for patients with advanced non–small-cell lung cancer (NSCLC). Patients with highly actionable gene variants have improved outcomes and reduced toxicities with the use of corresponding targeted agents. We sought to identify barriers to targeted agent use within the Veterans Health Affairs' National Precision Oncology Program (NPOP). METHODS: A retrospective evaluation of patients with NSCLC who underwent NGS multigene panels through NPOP between July 2015 and February 2019 was conducted. Patients who were assigned level 1 or 2A evidence for oncogenic gene variants by an artificial intelligence offering (IBM Watson for Genomics [WfG]) and NPOP staff were selected. Antineoplastic drug prescriptions and provider notes were reviewed. Reasons for withholding targeted treatments were categorized. RESULTS: Of 1,749 patients with NSCLC who successfully underwent NGS gene panel testing, 112 (6.4%) patients were assigned level 1 and/or 2A evidence for available targeted treatments by WfG and NPOP staff. All highly actionable gene variants were within ALK, BRAF, EGFR, ERBB2, MET, RET, and ROS1. Of these, 36 (32.1%) patients were not prescribed targeted agents. The three most common reasons were (1) patient did not carry a diagnosis of metastatic disease (33.3%), (2) treating provider did not comment on the NGS results (25.0%), and (3) provider felt that patient could not tolerate therapy (19.4%). No patients were denied access to level 1 or 2A targeted drugs because of rejection of a nonformulary drug request. CONCLUSION: A substantial minority of patients with NSCLC bearing highly actionable gene variants are not prescribed targeted agents. Further provider- and pathologist-directed educational efforts and implementation of health informatics systems to provide real-time decision support for test ordering and interpretation are needed.
Against the New Normal
Authors: Cubitt Sean 
Published: March 2021

Abstract
COVID-19 is now part of the resources out of which any future must be made. The temptation is to curl back into private misery and fatalism. The opportunity is to further the design of neonationalist, neoliberal returns to pre-1917 norms of extreme wealth, extreme poverty, and unmitigated exploitation of technical and ecological resources. The challenge is to build a future of public health, wealth, education, and environmental justice.
MIREyA: a computational approach to detect miRNA-directed gene activation
Authors: Elizarova Anna , Ozturk Mumin , Guler Reto , Medvedeva Yulia A. 
Published: March 2021

Emerging studies demonstrate the ability of microRNAs (miRNAs) to activate genes via different mechanisms. Specifically, miRNAs may trigger an enhancer promoting chromatin remodelling in the enhancer region, thus activating the enhancer and its target genes. Here we present MIREyA, a pipeline developed to predict such miRNA-gene-enhancer trios based on an expression dataset which obviates the need to write custom scripts. We applied our pipeline to primary murine macrophages infected by Mycobacterium tuberculosis (HN878 strain) and detected Mir22, Mir221, Mir222, Mir155 and Mir1956, which could up-regulate genes related to immune responses. We believe that MIREyA is a useful tool for detecting putative miRNA-directed gene activation cases. MIREyA is available from: https://github.com/veania/MIREyA
Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim
Authors: Menardo Fabrizio , Rutaihwa Liliana K. , Zwyer Michaela , Borrell Sonia , Comas Iñaki , Conceição Emilyn Costa , Coscolla Mireia , Cox Helen , Joloba Moses , Dou Horng-Yunn , Feldmann Julia , Fenner Lukas , Fyfe Janet , Gao Qian , García de Viedma Darío , Garcia-Basteiro Alberto L. , Gygli Sebastian M. , Hella Jerry , Hiza Hellen , Jugheli Levan , Kamwela Lujeko , Kato-Maeda Midori , Liu Qingyun , Ley Serej D. , Loiseau Chloe , Mahasirimongkol Surakameth , Malla Bijaya , Palittapongarnpim Prasit , Rakotosamimanana Niaina , Rasolofo Voahangy , Reinhard Miriam , Reither Klaus , Sasamalo Mohamed , Silva Duarte Rafael , Sola Christophe , Suffys Philip , Batista Lima Karla Valeria , Yeboah-Manu Dorothy , Beisel Christian , Brites Daniela , Gagneux Sebastien 
Published: March 2021

Background: Lineage 1 (L1) and 3 (L3) are two lineages of the Mycobacterium tuberculosis complex (MTBC) causing tuberculosis (TB) in humans. L1 and L3 are prevalent around the rim of the Indian Ocean, the region that accounts for most of the world’s new TB cases. Despite their relevance for this region, L1 and L3 remain understudied. Methods: We analyzed 2,938 L1 and 2,030 L3 whole genome sequences originating from 69 countries. We reconstructed the evolutionary history of these two lineages and identified genes under positive selection. Results: We found a strongly asymmetric pattern of migration from South Asia toward neighboring regions, highlighting the historical role of South Asia in the dispersion of L1 and L3. Moreover, we found that several genes were under positive selection, including genes involved in virulence and resistance to antibiotics. For L1 we identified signatures of local adaptation at the esxH locus, a gene coding for a secreted effector that targets the human endosomal sorting complex, and is included in several vaccine candidates. Conclusions: Our study highlights the importance of genetic diversity in the MTBC, and sheds new light on two of the most important MTBC lineages affecting humans.
Third-Party Consequences of Changes in Managerial Fiduciary Duties: The Case of Auditors’ Going Concern Opinions
Authors: Tan Liang , Ramalingegowda Santhosh , Yu Yong 
Published: March 2021

This study examines the effect of managerial fiduciary duties on the likelihood of firms receiving going concern (GC) opinions from their auditors. We exploit an influential 1991 legal ruling that expanded fiduciary duties of corporate directors and officers in favor of creditors for near-insolvent Delaware firms. Our difference-in-differences test reveals an increase in GC opinions following the ruling for near-insolvent Delaware firms. Further tests indicate an increase in type I audit opinion errors and no change in audit risk after the ruling. Additional analysis shows that, after the ruling, near-insolvent Delaware firms are less likely to dismiss their auditors following the receipt of a GC report. Overall, our findings are consistent with managers and directors with increased fiduciary duties toward creditors exerting less pressure on auditors and allowing them to reveal more GC opinions. Our results highlight important third-party consequences of changes in managerial fiduciary duties. This paper was accepted by Shiva Rajagopal, accounting.
Coherent control of the multiple wavelength lasing of ${\rm N}_2^ +$: coherence transfer and beyond
Authors: Zhang Xiang , Lu Qi , Zhang Zhedong , Fan Zhengquan , Zhou Dongjie , Liang Qingqing , Yuan Luqi , Zhuang Songlin , Dorfman Konstantin , Liu Yi 
Published: March 2021

Nitrogen molecules pumped by intense femtosecond laser pulses give rise
to coherent emission in the forward direction at a series of
wavelengths, coined “air lasing.” We demonstrate the coherent control
of these emissions via a pair of seeding pulses at two different
frequencies at low pressures, revealing a coherence transfer through
vibrational motion. It is found that the injection of a 427.8 nm
(391.4 nm) seeding pulse results in its amplification at the expense
of the 391.4 nm (427.8 nm) signal, demonstrating a competition between
the two spectral components of the emission from the upper level
population. Moreover, when the delay between the seeding and pump
pulses is finely tuned, the coherent control of both transitions is
observed via the coherence transfer. A microscopic molecular
relaxation model reproduces these observations, highlighting the
crucial role of electronic and vibrational coherences, as well as
their coupling, during the lasing action.
Attendee’s awareness about preventive chemotherapy neglected tropical diseases (PC-NTD) control during the first world neglected tropical diseases day in Ekiti State, Nigeria
Authors: Mogaji Hammed O. , Odoh Ikenna M. , Iyeh Concilia I. , Adeniran Abdulhakeem A. , Oyedeji Segun I. , Okoh Hilary I. , Bayegun Adedotun A. , Omitola Olaitan O. , Umunnakwe Cynthia U. , Olamiju Francisca O. , Olamiju Olatunwa J. , Ekpo Uwem F. 
Published: March 2021

Background
The need to control Neglected Tropical Diseases (NTDs) and sustain progress towards elimination through mass administration of medicines requires substantial communal participation. This study, therefore, assessed the knowledge and perception of attendees’ regarding NTDs and its control activities during the inaugural World NTD day event in Ekiti State, Nigeria.

Methodology
A cross-sectional study involving the administration of pretested semi-structured questionnaires to consenting attendees at the Inaugural World NTD day event was conducted on the 30th January, 2020. The questionnaire collected data on attendee’s demography, knowledge and awareness about NTDs and its control in Nigeria. Quantitative data were analysed using descriptive statistics in SPSS. 20.0 software and expressed as frequencies and percentages. However, qualitative data to support quantitative analysis were obtained using open-ended questionnaires and analysed thematically.

Principal findings/conclusion
A total of 309 attendees comprising 167 (54.0%) females, and 142 (46.0%) males participated in this study. By age groupings, majority 206 (66.7%) were within 15–25 years. 167 (54.8%) of the attendees have not heard about NTDs before, whereas 77(35.0%) have heard about NTDs through the advertisement of the event. 181(63.3%) were aware of ongoing NTD control programs in schools and communities. Also, 246 (83.4%) of them have not taken or do not know anyone that has taken drugs donated in schools or communities. The number of attendees 41(13.3%) who incorrectly classified malaria as NTDs is higher than those who recognized onchocerciasis 36 (11.7%) and worm infections 34(11.0%) as NTDs (p>0.05). This study has shown that awareness and knowledge about NTDs control activities in Ekiti State is low, thus justifying the event as an awareness day for addressing NTDs. Public enlightment and regular promotional activities such as media engagement will raise the public appreciation and participation in NTDs control activities.
Prevalence and associated factors of adolescent fatherhood in Ethiopia: A multilevel analysis using the 2016 Ethiopian demographic health survey data
Authors: Worku Misganaw Gebrie , Tesema Getayeneh Antehunegn , Teshale Achamyeleh Birhanu 
Published: March 2021

Background
Though the consequences of teenage pregnancy and early motherhood has been studied very well, little is known about the magnitude as well as the determinants of adolescent fatherhood. Unlike adolescent motherhood, limited public health programs are working on adolescent fatherhood. Currently, in developed countries, there is an increased work to acknowledge teen fathers in clinical practice and in the research forum, but still, there are more issues that need to be addressed in developing countries including Ethiopia. Therefore, this study aimed to investigate the prevalence and associated factors of adolescent fatherhood in Ethiopia based on the nationally representative survey.

Methods
This study used the 2016 Ethiopian Demographic and Health Survey (EDHS) data. A total weighted sample of 4455 adolescent men was included for the final analysis. For the associated factors, multilevel logistic regression analysis was conducted to consider the hierarchical nature of the EDHS data. Intra-class Correlation Coefficient (ICC), and deviance (-2LLR) were used for model comparison and for assessing model fitness. The model with the largest adjusted R2, lowest Bayesian Information Criteria (BIC) and the smallest cross-validation prediction error were considered as the best-fitted model. In the multivariable analysis, the Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) were reported to declare the presence of statistically significant factors associated with adolescent fatherhood, and variables with p-value <0.05 were considered as a significant variable.

Results
The prevalence of adolescent fatherhood in Ethiopia was 6.79% [95%CI; 6.08%, 7.56%]. Adolescent men with contraceptive knowledge [AOR = 4.25; 95%CI = 1.23, 14.69], age in 20 to 24 years [AOR = 7.93; 95%CI = 3.66, 17.27] and being Muslim [AOR = 1.84; 95%CI = 1.02, 3.39] were significantly associated with Higher odds of adolescent fatherhood. Individuals who initiate sex lately [AOR = 0.35; 95%CI = 0.22, 0.54], being in female-headed family [AOR = 0.46; 95%CI; 0.26, 0.82] and being from Amhara region [AOR = 0.35; 95%CI = 0.14, 0.84] were significantly associated with lower odds of adolescent fatherhood.

Conclusion
In this study, adolescent fatherhood was a common public health problem in Ethiopia as it is closely linked with poor quality of life and premature death (year of potential life lost). Age of respondent, knowledge of respondent about contraceptive methods, early initiation of sex, religion, sex of household head, and region were significantly associated with adolescent fatherhood. Therefore, program planners and decision-makers should give special attention to adolescent men through enhancing reproductive health services utilization and their knowledge towards it to decrease the incidence of adolescent fatherhood.