bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate Endoscopic Dacryocystorhinostomy in Patients With New Onset Acute Dacryocystitis
Authors: Yu Bo , Tu Yunhai , Zhou Guangming , Hong Huifeng , Wu Wencan 
Published: June 2021

ObjectivesTo compare the results of immediate endoscopic dacryocystorhinostomy (En‐DCR) and delayed En‐DCR in the treatment of new‐onset acute dacryocystitis (AD).Study DesignThis report describes a prospective randomized controlled interventional case series.MethodsBetween April 2009 and May 2019, 176 adults presenting at a tertiary eye care center with new‐onset AD manifesting within the last 48 hours were randomized into two groups. Altogether, 160 patients (48 male, 112 female) were included in this study, with a median age of 52.8 years (range: 18–82). Patients in group A underwent urgent En‐DCR, although those in group B underwent a delayed En‐DCR after 2 to 5 days of systematic antibiotic treatment. Variables compared between these two groups included the time for resolution of acute external inflammation, free lacrimal passage reconstruction (LPR) success rates, and complication rates.ResultsPostoperative data were collected from 86 patients in group A and 74 patients in group B. Patients that underwent immediate En‐DCR exhibited a quicker resolution of acute inflammation (P < .05). Patients that underwent delayed surgery experienced compilations of acute inflammation, with 10 ultimately developing skin fistulization and 4 exhibiting orbital cellulitis before surgery. The success rate of LPR at 12 months after surgery was higher in group A (81/86 94.2%) relative to group B (62/74 83.8%; P < .05).ConclusionsImmediate En‐DCR is associated with quicker disease resolution and a higher long‐term success rate, although reducing the incidence of complications including skin fistulization and the spread of infection.Level of Evidence3 Laryngoscope, 132:278–283, 2022
Microstructural Periodic Arrays in Poly(Butylene Adipate) Featured with Photonic Crystal Aggregates
Authors: Nagarajan Selvaraj , Woo Eamor M. , Su Chi‐Hsuan , Yang Cheng‐En 
Published: June 2021

AbstractPoly(butylene adipate) (PBA) self‐aggregation into unique periodicity correlating to its interfacial photonic properties is probed in detail. Investigations on the unique periodic morphology and top‐surface and interior architectures in specifically crystallized PBA are focused on its novel photonic patterns with periodic gratings. Detailed analysis of the interior lamellae from ringless to periodically ordered aggregates (crystallized at 33–35 °C vs. Tc = 30 °C) serves as ideal comparisons. Each interior arc‐shape shell is composed of tangential and radial lamellae mutually intersecting at 90o angle. The interior layer thickness in SEM‐revealed arc‐shape shish‐kebab shell is exactly equal to the optical inter‐band spacing (≈6 µm). A 3D assembly mechanism of periodically banded PBA crystals is proposed, where the orderly arrays on top surfaces as well as the interior microstructures of strut‐rib alternate‐layered assembly resemble nature's photonic crystals and collectively account for the interfacial photonic properties in the ring‐banded PBA crystal that is novel and has potential applications in future.
Specific Ion Effects of Azobenzene Salts on Photoresponse of PNIPAm in Aqueous Solutions
Authors: Wei Shuang , Zhang Zechuan , Dong Weibin , Liang Ting , Ji Junyi , Tian Wen , Tan Shuai , Zhao Qiang , Wang Caihong , Wu Yong 
Published: June 2021

AbstractIonic species are important to dominate phase separation behaviors of poly(N‐isopropylacrylamide) (PNIPAm) in aqueous solutions. Herein, photoresponsive azobenzene‐based salts with various ions are prepared and their photoresponsive ion effects on clouding temperatures (TcpS) of PNIPAm in aqueous solutions are explored. It is found that, despite of various structures of anions and cations, trans‐TcpS under vis light irradiation are always higher than cis‐TcpS under UV irradiation. Particularly, Hofmeister effect of anions on TcpS is roughly observed. For example, azobenzene with kosmotropic CO32− gives the lowest cis‐Tcp while in use of typical chaotropic anions, such as ClO4−, azobenzene isomerization less affects values of Tcps. In another hand, azobenzene‐based metallic salts containing lithium, sodium, and potassium cations also demonstrate photoresponsive Hofmeister effect. Trans‐metallic azobenzene demonstrates a chaotropic effect on Tcps while UV induces kosmotropic behaviors on TcpS. Additionally, ionic conduction of the solution along with photoresponsive phase separations is also investigated and PNIPAm aggregations induce a sharp reduction of ion conduction during UV light illumination.
Deterministic and Stochastic Parameter Estimation for Polymer Reaction Kinetics I: Theory and Simple Examples
Authors: Wulkow Niklas , Telgmann Regina , Hungenberg Klaus‐Dieter , Schütte Christof , Wulkow Michael 
Published: June 2021

AbstractTwo different approaches to parameter estimation (PE) in the context of polymerization are introduced, refined, combined, and applied. The first is classical PE where one is interested in finding parameters which minimize the distance between the output of a chemical model and experimental data. The second is Bayesian PE allowing for quantifying parameter uncertainty caused by experimental measurement error and model imperfection. Based on detailed descriptions of motivation, theoretical background, and methodological aspects for both approaches, their relation are outlined. The main aim of this article is to show how the two approaches complement each other and can be used together to generate strong information gain regarding the model and its parameters. Both approaches and their interplay in application to polymerization reaction systems are illustrated. This is the first part in a two‐article series on parameter estimation for polymer reaction kinetics with a focus on theory and methodology while in the second part a more complex example will be considered.
Asymmetric Dopamine Transporter Loss Affects Cognitive and Motor Progression in Parkinson's Disease
Authors: Fiorenzato Eleonora , Antonini Angelo , Bisiacchi Patrizia , Weis Luca , Biundo Roberta 
Published: June 2021

ABSTRACTBackgroundAsymmetric hemispheric loss of dopaminergic neurons is one of the characteristic features of Parkinson's disease (PD). However, it is still debated if right or left asymmetry differently affects cognitive and motor progression.ObjectivesThe objective of this study was to investigate, for the first time, the relevance of dopamine transporter (DAT) asymmetry on cognitive and motor manifestations at onset and at 4‐year progression in drug‐naïve PD.MethodsFrom the Parkinson's Progression Markers Initiative multicenter cohort, we identified 249 right‐handed patients with PD with baseline asymmetry greater than 20% in putamen DAT binding at single‐photon emission computed tomography. A predominant putamen asymmetry was found on the left in 143 patients (PD‐left), and on the right side in 106 patients (PD‐right); we compared them with 196 healthy controls. Patients were followed longitudinally (2‐year and 4‐year visits), examining their clinical, cognitive, and imaging data.ResultsAt baseline, the PD‐left group showed worse performance on the Symbol Digit Modality Test, an attention and processing‐speed test, and lower cerebrospinal fluid β‐amyloid levels than the PD‐right group. These differences were maintained at follow‐up, declining over time in both groups. By contrast, the PD‐right group showed greater motor impairment at baseline, which increased over 4 years. Striatal DAT binding decreased over time in both groups, but the PD‐right group showed a steeper decline, particularly during the first 2‐year follow‐up. Putaminal asymmetry assessed at baseline was maintained over time.ConclusionsThese findings suggest that hemispheric asymmetric dopaminergic denervation influences PD cognitive and motor performance as well as progression. Predominant right hemisphere nigrostriatal dopaminergic loss is associated with greater motor severity, whereas more pronounced left hemisphere denervation affects cognitive manifestations at onset and their progression. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Design of a compact UWB MIMO‐diversity antenna incorporating fractal inspired isolation structure with band notch characteristics
Authors: Bhattacharjee Anindita , Karmakar Anirban , Saha Anuradha , Bhattacharya Diptendu 
Published: June 2021

AbstractIn this communication, a new compact ultra‐wideband (UWB) multiple‐input multiple‐output (MIMO) antenna with band notch characteristics is presented for wireless application. It comprises of two unique monopole antenna elements sharing a similar ground plane. To reduce the coupling between antenna elements, a modified T‐shaped stub equipped with Minkowski fractal shape elements are introduced on the ground plane which in turn establish a good isolation between radiating elements. A band notch is achieved at 5.45 GHz by adding two additional rectangular stubs at 45° where symmetric slots have been etched. The efficiency and gain of the antenna drops significantly at the centre of the notch band which indicates good interference suppression. Results show that the designed antenna delivers widest impedance bandwidth (−10 dB) throughout the operating band of 3.1–20 GHz (of 146% impedance bandwidth) which covers UWB as well as Ku‐band. The antenna also produces ‐18 dB isolation for most of the operating band and ‐16 dB up to 6 GHz. The optimized antenna is fabricated and tested showing |S11| characteristics below −10 dB from 3.1 to 20 GHz band. The dimension of the proposed antenna is 18 × 26 × 1.6 mm3. Results show that the simulated characteristics are in good agreement with the measured counterpart. The designed MIMO antenna is an appropriate candidate for UWB and other wireless applications.
A systematic review of the effectiveness of yoga on pain, physical function, and quality of life in older adults with chronic musculoskeletal conditions
Authors: Denham‐Jones Laura , Gaskell Lynne , Spence Nicola , Tim Pigott  
Published: June 2021

AbstractObjectivesExercise interventions suitable for older adults can help to slow and manage age‐related conditions. This systematic review looks at age‐related musculoskeletal conditions in a population with a mean age over 50 years, evaluating the effectiveness of yoga for pain, physical function, and quality of life.MethodsCENTRAL,CINAHL, Pubmed, PsycInfo, SCOPUS, Sports Discus, Web of Science Core Collection, and Google Scholar were searched. Study selection and quality screening using the Cochrane risk of bias tool were conducted by two reviewers to mitigate bias. PRISMA guidelines were followed in conducting and reporting the review.Results11 studies met inclusion criteria with a total sample of 2221 (≥70% female). Eight studies measured pain, six showing significant effectiveness (p=≤0.05), for lower limb osteoarthritis (OA), hand OA, and neck pain. Nine studies measured physical function, four showing significant effects, for lower limb OA and sarcopenia. Significant quality of life effects were found for restless leg syndrome compared to baseline.ConclusionModerate evidence was found for pain effects, generalisable for OA based on sub‐group analysis. Effective trials were mostly short‐term using at minimum one 60‐min group class, and an average of four 30‐min home practice sessions weekly. Findings support the use of props and modifications to address age‐related physical limitations. Yoga was well‐received with good adherence, but effects on a par with other exercise. There was an absence of quality of life effects in short term. Mixed methods studies could lead to further insight into the qualitative aspects of yoga practice for older adults.
Identification of the components for investigation of the psychological strength of nursing applicants: A qualitative study
Authors: Bagheriyeh Farzaneh , Ghahramanian Akram , Valizadeh Leila , Zamanzadeh Vahid , Dickens Geoffrey 
Published: June 2021

AbstractAimThere is a lack of clarity about the components which would signify appropriate psychological strengths among nursing student candidates. This study was conducted to identify such components from the viewpoint of the clinical nurses and nursing instructors.DesignA qualitative study.MethodsThis study comprised qualitative research using a conventional content analysis approach. Participants were 25 nurses and nursing instructors. Data were collected in audio‐recorded and transcribed semi‐structured interviews and were analysed using MAXQDA10 software.ResultsAnalysis revealed four main categories including "anger management," "Stress/distress management," "self‐belief" and "aptitude for hard work."ConclusionsThis study identified core components for future investigations into the psychological strengths of nursing applicants. This study provides specific testable hypotheses for future research endeavours. It is recommended that the researchers investigate the appropriateness of the components identified in this study to assess the psychological strength of the applicants in the longitudinal studies.
The generalizability of empirically derived syndromes of collateral‐reported elder psychopathology across 11 societies
Authors: Ivanova Masha Y. , Achenbach Thomas M. , Rescorla Leslie A. , Turner Lori V. , Dumas Julie A. , Almeida Vera , Anafarta‐Sendag Meltem , Carlos Caldas J. , Chen Yi‐Chuen , da Silva Oliveira Margareth , Erol Nese , Funabiki Yasuko , Guðmundsson Halldór S. , Kim Young A. , Leite Manuela , Liu Jianghong , Markovic Jasminka , Misiec Monika , Oh Kyung J. , Shi Shupeng , Sigurðardóttir Sigurveig H. , Sokoli Elvisa , Tomasevic Tanja , Zasępa Ewa 
Published: June 2021

AbstractThe purpose of this study was to test whether a syndrome model of elder psychopathology derived from collateral ratings, such as from spouses and adult children, in the United States would be generalizable in 11 other societies. Societies represented South America, Asia, and Europe. The Older Adult Behavior Checklist (OABCL) was completed by collateral informants for 6141 60‐ to 102‐year‐olds. The tested model comprised syndromes designated as Anxious/Depressed, Worries, Somatic Complaints, Functional Impairment, Memory/Cognition Problems, Thought Problems, and Irritable/Disinhibited. The model was tested using confirmatory factor analyses in each society separately. The primary model fit index showed a good fit for all societies, while the secondary model fit indices showed acceptable to a good fit for all societies. The items loaded strongly on their respective factors, with a median item loading of 0.69 across the 11 societies. By syndrome, the overall median item loadings ranged from 0.47 for Worries to 0.77 for Functional Impairment. The OABCL syndrome structure was thus generalizable across the tested societies. The OABCL can be used for broad assessment of psychopathology for elders of diverse backgrounds in nursing services and research.
Diagnostic accuracy of image‐guided core needle biopsy of non‐central nervous system tumors in children
Authors: Bruinsma Rixt S. , Nievelstein Rutger A.J. , Littooij Annemieke S. , Vermeulen Marijn A. , van de Ven Cornelis P. , van Noesel Max M. , Wijnen Marc H.W.A. , van der Steeg Alida F.W. , de Krijger Ronald R. 
Published: June 2021

AbstractBackground and aimsCore needle biopsies (CNB) are less invasive, cause less morbidity, and have lower costs than open biopsies (OB). However, the number of studies reporting CNB accuracy in pediatric tumors is limited and series are small. The aim of this study is to investigate if CNB diagnosis is concordant with the final diagnosis in pediatric solid non‐central nervous system (CNS) tumors.MethodsData from all patients treated in a single center between November 2014 and December 2019 were collected from the national pathology database and from local medical records. Data collection included age, sex, CNB diagnosis, final diagnosis, number of cores obtained, number of cores used for histology, cumulative core length, greatest dimension of the lesion, lesion volume, and complications.ResultsOut of 361 CNB, 95.6% (345/361) provided a diagnosis. A resection or follow‐up biopsy was performed in 201 cases. The final diagnosis was concordant with the CNB in 100% (201/201) of cases. The age, number of cores used for histology, and the greatest dimension of the lesion did not significantly differ between diagnostic and nondiagnostic CNB. The cumulative core length of diagnostic CNB was significantly higher than in the nondiagnostic group (24.72 mm vs. 13.37 mm, p‐value .022). Complications occurred in 2.1% (7/337) of CNB procedures. Molecular analysis was successful in 228/233 (98%) of cases in which it was performed.ConclusionsCNB diagnosis is highly concordant with the final diagnosis and the diagnostic rate is high. The complication rate in CNB is low.
Effects of zoledronic acid on osteonecrosis and acute lymphoblastic leukemia treatment efficacy in preclinical models
Authors: Janke Laura J. , Kim Jieun , Payton Monique A. , Jenkins David A. , Cai Xiangjun , Finch Emily R. , Liu Yiwei , Relling Mary V. , Karol Seth E. 
Published: June 2021

AbstractBackgroundOsteonecrosis is a devastating side effect of acute lymphoblastic leukemia (ALL) therapy. Associations between bone density loss and osteonecrosis have sparked interest in using bisphosphonates to reduce this complication.ProcedureWe assessed the impact of zoledronic acid (ZA) on the development of osteonecrosis in murine models when used either throughout therapy (continuous administration) or late in therapy after vascular lesions have developed but before osteonecrosis has occurred. Effects on bone density were measured using microcomputed tomography (μCT)‐assessed tibial cortical thickness, while osteonecrosis was assessed histologically in the distal femur. Effects on antileukemic efficacy of chemotherapy were evaluated in both immunocompetent/syngeneic and patient‐derived xenograft (PDX) models.ResultsContinuous administration of ZA with chemotherapy prevented chemotherapy‐associated bone loss (p < .001) and reduced osteonecrosis (p = .048). Late initiation of ZA diminished bone loss (p < .001) but had no impact on the development of osteonecrosis (p = .93). In the immunocompetent murine ALL model, mice treated with ZA and chemotherapy succumbed to leukemia sooner than mice treated with chemotherapy alone (p = .046). Analysis using PDX showed a nonsignificant decrease in survival with ZA (p = .17).ConclusionOur data indicate ZA may prevent osteonecrosis if begun with chemotherapy but showed no benefit when administered later in therapy. However, ZA may also reduce the antileukemic efficacy of chemotherapy.
Therapeutic effects of β‐caryophyllene on proliferative disorders and inflammation of the gerbil prostate
Authors: Castro Nayara Fernanda da Costa , Jubilato Fernanda Costa , Guerra Luiz Henrique Alves , Santos Fernanda Cristina Alcantara dos , Taboga Sebastião Roberto , Vilamaior Patrícia Simone Leite 
Published: June 2021

AbstractBackgroundThe prostate is susceptible to changes in androgen levels, which can play an important role in the development of Benign Prostatic Hyperplasia (BPH). Natural compounds have beneficial properties for organisms and can be an important therapeutic strategy in the treatment of diseases. β‐Caryophyllene (BCP) is a phytocannabinoid present in several medicinal and food plants species and has shown beneficial effects in different organs. However, little is known about its effects on the prostate. The present study seeks to evaluate the effects of exposure to BCP on the morphophysiology of the ventral prostate of adult gerbils supplemented with testosterone.MethodsAnimals were distributed into four groups (n = 8/group): Intact control (C); β‐Caryophyllene (BCP): β‐Caryophyllene (50 mg/kg/day); Testosterone (T): animals received subcutaneous injections of Testosterone Cypionate (3 mg/Kg), on alternate days, for one month and were euthanized 30 days supplementation ended; Testosterone and β‐Caryophyllene (TBCP): animals were exposed to testosterone cypionate (3 mg/Kg) to induce hyperplastic alterations followed by daily BCP (50 mg/kg). Morphological, biometric, immunohistochemical, and serological analyses were performed.ResultsProliferative disorders and inflammatory foci were present in the ventral prostate of all experimental groups. An increase in the multiplicity of benign intraepithelial neoplasm and subepithelial inflammatory foci was observed in T group. The incidence of intraluminal inflammatory foci and microinvasive carcinoma was verified only in the T group. Cellular rearrangement and tissue remodeling occurred in the prostate of groups exposed to phytocannabinoids. A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells.ConclusionBCP impacts the tissue remodeling process in the premalignant prostate environment and that the use of this phytocannabinoid can have a promising effect in the handling of BPH.
Immune checkpoint B7‐H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer
Authors: Nunes‐Xavier Caroline E. , Kildal Wanja , Kleppe Andreas , Danielsen Håvard E. , Wæhre Håkon , Llarena Roberto , Mælandsmo Gunhild M. , Fodstad Øystein , Pulido Rafael , López José I. 
Published: June 2021

AbstractBackgroundNovel immune checkpoint‐based immunotherapies may benefit specific groups of prostate cancer patients who are resistant to other treatments.MethodsWe analyzed by immunohistochemistry the expression of B7‐H3, PD‐L1/B7‐H1, and androgen receptor (AR) in tissue samples from 120 prostate adenocarcinoma patients treated with radical prostatectomy in Spain, and from 206 prostate adenocarcinoma patients treated with radical prostatectomy in Norway.ResultsB7‐H3 expression correlated positively with AR expression and was associated with biochemical recurrence in the Spanish cohort, but PD‐L1 expression correlated with neither of them. Findings for B7‐H3 were validated in the Norwegian cohort, where B7‐H3 expression correlated positively with Gleason grade, surgical margins, seminal vesicle invasion, and CAPRA‐S risk group, and was associated with clinical recurrence. High B7‐H3 expression in the Norwegian cohort was also consistent with positive AR expression.ConclusionThese results suggest distinct clinical relevance of the two immune checkpoint proteins PD‐L1 and B7‐H3 in prostate cancer. Our findings highlight B7‐H3 as an actionable novel immune checkpoint protein in prostate cancer.