bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
Authors: Liu Yi , Liang Xuelei , Wu Haixuan , Zhuo Fenglin 
Published: November 2021

Introduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/systemic lupus erythematosus (SLE) overlap syndrome with hair loss as the first symptom.Case Presentation: A 48-year-old female presented with alopecia for half a year, and skin lesions accompanied by itching on her face, trunk, and limbs for 3 months. She had a history suggestive of photosensitivity. Laboratory tests and histopathology were performed for diagnosis. Histopathologic features of the upper arm and back of the hand were consistent with BLP, whereas the scalp lesion indicated LE. Laboratory examination indicated positive for antinuclear antibody (ANA) (1:160), leukopenia, increased urinary protein, decreased C3/C4, and normal BP180. The patient was given glucocorticoid combined with acitretin and immunosuppressive therapy after a definite diagnosis of BLP/SLE overlap syndrome. The lesions of the patient disappeared and some hair had regrown during the two years of follow-up.Conclusion: This is the first reported case of BLP/SLE overlap syndrome which responded well to glucocorticoids, retinoids, and immunosuppressive drugs. Multiple biopsies from characteristic lesions will guide doctors to avoid misdiagnoses and delayed treatment.
Impact of Diabetes on Platelet Function in Acute Ischemic Stroke Patients Taking Dual Antiplatelet Therapy
Authors: Guo Yinping , Zhang Yi , Zhao Jing , Wu Lingshan , Yu Zhiyuan , He Dan , Huang Hao , Luo Xiang 
Published: November 2021

Objectives: Diabetes mellitus (DM) is a significant risk factor for ischemic stroke and associated with platelet reactivity. We aim to evaluate the effect of DM on platelet function in acute ischemic stroke patients taking dual antiplatelet therapy (DAPT).Methods: We consecutively included patients with acute ischemic stroke taking DAPT. Platelet function was assessed by thromboelastography and the arachidonic acid (AA) or adenosine diphosphate (ADP) induced platelet inhibition rate were used to confirmed the high-residual on-treatment platelet reactivity (HRPR) to aspirin or clopidogrel. We classified patients into DM and non-DM groups. The association between DM and platelet function was assessed and the confounding factors were adjusted by propensity score matching (PSM) analysis. The independent risk factors of HRPR were determined by multivariate logistic regression analysis.Results: A total of 1,071 acute ischemic stroke patients, 712 in the non-DM group and 359 in the DM group, were included. Patients with DM had a significantly higher maximum amplitude (63.0 vs. 62.0 mm, P &lt; 0.01), ADP-induced clot strength (34.6 vs. 30.3 mm, P &lt; 0.01) and clopidogrel HRPR rate (22.6% vs. 17.3%, P = 0.038) than those without DM. Among 662 patients after PSM, the maximum amplitude (63.1 vs. 62.5 mm, P = 0.032), ADP-induced clot strength (34.6 vs. 29.3 mm, P &lt; 0.01) and clopidogrel HRPR rate (23.0% vs. 15.7%, P = 0.018) is still higher in the DM group. DM was an independent factor of clopidogrel HRPR (OR = 1.48, 95% CI: 1.03–2.07, P &lt; 0.05).Conclusions: In acute ischemic stroke patients taking DAPT, DM is associated with increased platelet reactivity and higher prevalence of clopidogrel HRPR.
Genistein, a Natural Isoflavone, Alleviates Seizure-Induced Respiratory Arrest in DBA/1 Mice
Authors: Guo Jialing , Min Daniel , Feng Hua-Jun 
Published: November 2021

Objective: Sudden unexpected death in epilepsy (SUDEP) is a fatal event that ranks second in years of potential life lost among neurological disorders. Seizure-induced respiratory arrest (S-IRA) is the primary instigator leading to death in many SUDEP cases. However, there are currently no effective preventive strategies against S-IRA other than the seizure control. Therefore, it is critical to develop new avenues to prevent SUDEP by investigating the pharmacological interventions of S-IRA. In the present study, we examined the effect of genistein, an isoflavone found in various dietary vegetables, on the incidence of S-IRA in DBA/1 mice.Methods: DBA/1 mice exhibited generalized seizures and S-IRA when subjected to acoustic stimulation. Genistein was intraperitoneally administered alone or in combination with an adrenoceptor antagonist and a serotonin (5-HT) receptor antagonist, respectively. The effects of drug treatments on S-IRA incidence and seizure behaviors were examined.Results: The incidence of S-IRA in DBA/1 mice was significantly reduced 2 h after injection of genistein at 1–90 mg/kg as compared with that in the vehicle control. Genistein could block S-IRA without interfering with any component of seizures, especially at relatively lower dosages. The S-IRA-suppressing effect of genistein was reversed by an α2 adrenoceptor antagonist but was not altered by an α1 antagonist. The inhibitory effect of genistein on S-IRA was not affected by a 5-HT3 or 5-HT2A receptor antagonist.Significance: Our data show that genistein reduces S-IRA incidence and can specifically block S-IRA in DBA/1 mice. Its suppressing effect on S-IRA is dependent on activating α2 adrenoceptors. Our study suggests that genistein, a dietary supplement, is potentially useful to prevent SUDEP in at-risk patients.
Is 18F-FDG PET/CT Beneficial for Newly Diagnosed Breast Cancer Patients With Low Proportion of ER Expression?
Authors: Liu Jiachen , Sun Runlu , Yin Yuping , Li Jingyan , Liu Xuming , Liu Sheng , Zhang Zhanlei , Hu Jieting , Wan Xiaoting , Zhang Hong 
Published: November 2021

ObjectiveIt is unclear whether the receptor status of breast malignancy or the proportion of receptors expression is useful in the interpretation of 18F-FDG PET/CT. This study’s purpose was to analyze whether 18F-FDG PET/CT was valuable for helping newly diagnosed breast cancer patients find suspected or unsuspected metastasis lesions based on the proportion of receptors expression.Materials and MethodsEighty newly diagnosed breast cancer patients were divided into six groups, containing N0 (no extraaxillary lymph node metastasis), N1 (extraaxillary lymph node metastasis), M0 (no distant metastasis), and M1 (distant metastasis) groups, C0 (no unsuspected metastasis), and C1 (unsuspected metastasis and treatment plan changed) detected by PET/CT. The main data, including the proportion of receptors ER (estrogen receptor), PR (progesterone receptor), and Her-2 (human epidermal growth factor receptor 2) status, were extracted. Simple correlation and logistic regression were preformed to analyze the association between them.ResultsPatients in N1 group had lower proportion of ER (%) and PR (%) than that in N0 group (ER: 2 [0–80] vs. 80 [15–95]; PR: 1 [0–10] vs. 20 [0–45], p&lt;0.001). Moreover, the proportions of ER and PR were negatively correlated with N1 (ER: [r= −0.339, p= 0.002], PR: [r= −0.247, p= 0.011]) by simple correlation. Also, patients in C1 group had lower proportion of ER (%) and PR (%) than those in C0 group (ER: 10 [0–85] vs. 80 [15–90], p=0.026; PR: 1 [0–10] vs. 20 [0–70], p=0.041), while the distribution of ER and PR between M1 and M0 group had no significant difference. After the adjustment of traditional factors, the negative correlation between the proportion of ER (OR=0.986, 95% CI of OR [0.972–0.999], p=0.016) and C1 was found by logistic regression, cutoff value was 25% (ER) calculated by ROC (Receiver Operating Characteristic) curve (AUC [Area Under Curve]= 0.647, p=0.024).ConclusionThe proportion of ER in newly diagnosed breast cancer was negatively correlated with unsuspected metastasis detected by 18F-FDG PET/CT. 18F-FDG PET/CT might be recommended for newly diagnosed breast cancer patients with single lesions when the ER expression proportion is less than 25% to find unsuspected metastasis lesions and to modify treatment plan contrasted with conventional imaging and clinical examination.
Development of an Instrument to Assess Spirituality: Reliability and Validation of the Attitudes Related to Spirituality Scale (ARES)
Authors: Braghetta Camilla Casaletti , Gorenstein Clarice , Wang Yuan Pang , Martins Camila Bertini , Leão Frederico Camelo , Peres Mario Fernando Prieto , Lucchetti Giancarlo , Vallada Homero 
Published: November 2021

Background: Several instruments that measure spirituality present overlaps with positive emotions, impacting the interpretation of their findings. In order to minimize these problems, we aimed to develop, assess the reliability and validate a new scale to evaluate spirituality.Methods: The instrument was designed using a theoretical framework minimizing tautological issues (i.e., Koenig’s framework), a qualitative study investigating the definitions of spirituality, the development of the first version of instrument by experts’ meetings and a qualitative cognitive debriefing. Then, the instrument was examined for its content validity by a multidisciplinary group of judges and was pilot-tested in two different groups – less religious (medical students – n = 85) and more religious (practicing religious members – n = 85). Finally, psychometric properties and validity were assessed.Results: The developed Attitudes Related to Spirituality Scale (ARES) is a self-report 11-item instrument using five-level Likert items. ARES presented appropriate psychometric properties revealing excellent internal consistency (alpha = 0.98) and temporal stability (ICC = 0.98). Likewise, ARES was strongly correlated with other validated R/S instruments (i.e., Duke Religion Index and Brief Multidimensional Measure of Religiousness/Spirituality) and was able to discriminate higher and lower religious groups. In the exploratory factor analysis, a unidimensional structure of the scale was described. Fit indices for the scale demonstrated good fit in the unidimensional model.Conclusion: The ARES is a reliable, valid and stable one-dimension instrument that is appropriate for use in the Portuguese-speaking population.Descriptors: Spirituality; Scale; Factorial Analysis; Instrument; Measure; Psychometrics.
Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
Authors: Marks Michael , Lal Sham , Brindle Hannah , Gsell Pierre-Stéphane , MacGregor Matthew , Stott Callum , van de Rijdt Martijn , Almazor Guillermo Gutiérrez , Golia Suman , Watson Conall , Diallo Abdourahamane , Toure Alhassane , Houlihan Catherine , Keating Patrick , Martin Hélène , Restrepo Ana-Maria Henao , Anokwa Yaw , Roberts Chrissy H. 
Published: November 2021

Background:ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-source options for off-grid use in public health data collection, management, analysis, and reporting. During the 2018–2020 Ebola epidemic in the North Kivu and Ituri regions of Democratic Republic of Congo, we used these tools to support the DRC Ministère de la Santé RDC and World Health Organization in their efforts to administer an experimental vaccine (VSV-Zebov-GP) as part of their strategy to control the transmission of infection.Method:New functions were developed to facilitate the use of ODK, Enketo andRin large scale data collection, aggregation, monitoring, and near-real-time analysis during clinical research in health emergencies. We present enhancements to ODK that include a built-in audit-trail, a framework and companion app for biometric registration of ISO/IEC 19794-2 fingerprint templates, enhanced performance features, better scalability for studies featuring millions of data form submissions, increased options for parallelization of research projects, and pipelines for automated management and analysis of data. We also developed novel encryption protocols for enhanced web-form security in Enketo.Results:Against the backdrop of a complex and challenging epidemic response, our enhanced platform of open tools was used to collect and manage data from more than 280,000 eligible study participants who received VSV-Zebov-GP under informed consent. These data were used to determine whether the VSV-Zebov-GP was safe and effective and to guide daily field operations.Conclusions:We present open-source developments that make electronic data management during clinical research and health emergencies more viable and robust. These developments will also enhance and expand the functionality of a diverse range of data collection platforms that are based on the ODK software and standards.
Kimiko Does Cancer
Authors: Folkmarson Käll Lisa , Tobimatsu Kimiko , Geniza Keet 
Published: November 2021

KIMIKO DOES CANCER is a graphic memoir written by Kimiko Tobimatsu and illustrated by Keet Geniza. The book tells the story of Kimiko’s experience with breast cancer as a young, queer, mixed-race woman. Set in Toronto, Canada, Kimiko Does Cancer seeks to upend the traditional cancer narrative, confronting issues such as dating while in induced menopause, navigating work and treatment, and talking to well- meaning friends, health care professionals, and other cancer survivors.
In the interview below, Lisa Folkmarson Käll talks with Kimiko and Keet about their three-year long collaboration on the project, their hopes for it, the importance of representation and the difficulties of dealing with vulnerability.
Page references in the text are to Kimiko Tobimatsu and Keet Geniza’s Kimiko Does Cancer: A Graphic Memoir (Vancouver: Arsenal Pulp Press, 2020).
Use of Active Games in Physical and Tactical Training of Young Handball Players at the Initial Stage
Authors: Hrynchenko Ihor , Tykhonova Asia , Karpunets Tеtiana , Chupryna Olexandr 
Published: November 2021

The purpose of the study is to increase the effectiveness of physical and technical training of young handball players aged 10-11 by means of moving games, game exercises and relays at the stage of initial training during the pedagogical experiment in 2020-2021.
Methodology. The following methods were used in the study: theoretical analysis and generalization of scientific and methodological literature, control and pedagogical checking (tests), pedagogical observations, anthropometry. Statistical processing of experimental data was performed using the statistical processing package STATGRAPHICS Plus for Windows (according to standard methods). The study involved young handball players aged 10-11, the first and second year of training in sport school №3 in Kharkiv during a year. The technique was implemented for 9 months (74 lessons), 3 times a week, and lasting 20 minutes.
Results. We claim that the physical fitness of handball players is closely related to various aspects of training. The selected tests fully characterize the physical development and functional state of the main life support systems of a body and allow determining the effectiveness of the proposed authors’ method. The specially selected combinations with the use of moving games, game exercises and relays help to increase the level of technical training of young handball players. Analysis of the final indicators in the experimental group revealed a significant increase corresponding to the 5% level of significance in terms of execution of free throws and movement in the protective rack of the handball player. The average group values of the accuracy of free throws increased by 49.5%, and the average speed of movement in the protective rack of a handball player after the experiment increased by 8.3%. The rate of transfer of the ball to the wall in the experimental group increased by 25.1%, which indicates a significant increase in the result at P <0,01.
Conclusion. The results obtained during the experiment confirmed the effectiveness of our developed methods of training with the purposeful use of moving games, game exercises and relay races at the initial stage of training young handball players.
Correlation of THz-wave absorption properties by different halogen elements in FAPb(Br, I)-based hybrid perovskite thin films
Authors: Maeng Inhee , Matsuyama Asuka , Nakamura Masakazu , Jung Min-Cherl 
Published: November 2021

Abstract
Understanding the controllability of the THz-wave absorption property of organic–inorganic hybrid perovskite (OHP) thin films is necessary to advance the THz-based application field. Here, we found the correlation of THz-wave absorption property by different halogen elements in FAPb(Br, I)-based hybrid perovskite thin films fabricated by sequential vacuum evaporation. We confirm that the selection of halogen elements and their concentration ratio can be changed to systematically control the THz conductivity property.
Assessment of Anxiety due to COVID-19 among the Surgery Staff of the René ESSOMBA Theater "BORE" at the Yaoundé Central Hospital
Authors: Daniel Biwole , Ebogo Messina , Freddy Bombah , Nkoa Enrique Zoa , Boukar Yannick Ekani , Eone Daniel Handy 
Published: November 2021

Background: The COVID-19 pandemic has had a negative impact on healthcare systems worldwide, including surgical disciplines. To date, only a few studies have assessed the effects of the ongoing pandemic on the mental state of those potentially exposed through their daily activities, such as operating theatre staff. The present study aimed to determine the prevalence of anxiety among the operating theatre staff "BORE" during the COVID-19 pandemic.
Methods: From 13 January to 19 February 2021, we conducted a cross-sectional study using a pre-designed online form. This form was disseminated to participants via social networks. The data collection form was divided into three parts: one part was for socio-demographic information, the second part was for professional information, and the third part was for assessing the anxiety score by the Hamilton Anxiety Scale (HAM-A).
Results: A total of 42 questionnaires were fully completed and retained for analysis. The sex ratio was 1.67, with 16 men and 26 women. COVID-19 anxiety with mild severity (HS ˂ 17) was found in 22 (55.4%) of the participants, and 33.3% had moderate to severe depression, while 11.3% had severe anxiety.
Conclusion: About 4/5 of the participants in our survey suffered from anxiety due to the COVID-19 pandemic. This study highlights the need for psychological assistance for health care workers, especially the operating theatre staff of the Yaounde Central Hospital.
Sistem Informasi Monitoring Produksi Obat Pada Lembaga Farmasi Pusat Kesehatan Angkatan Darat (Puskesad) Bandung
Authors: Saptohadi Yulianto Dwi , Hendro P Tacbir , Hadiana Asep Id 
Published: November 2021

Abstract- Utilization of Monitoring Information Systems is very useful, because it will make it easier for companies to get information. Likewise, at the Pharmaceutical Institution of a drug production company, information in the form of drug production will be conveyed to the head of the institution, where the head of the institution is the employer of the company involved in the ongoing project. Not only does it stop at the process of producing drugs, but the system also includes information on storing production drugs to the warehouse. By implementing the Monitoring Information System the company is expected to be able to monitor all information activities in the process of drug production and storage of drugs in the warehouse, so that the process can be carried out systemically.Abstrak- Pemanfaatan Sistem Informasi Monitoring sangat berguna, karena akan membuat perusahaan semakin mudah dalam mendapatkan informasi. Demikian dengan halnya pada Lembaga Farmasi salah satu perusahaan produksi obat, informasi berupa produksi obat akan disampaikan kepada kepala lembaga, di mana kepala lembaga merupakan atasan perusahaan yang terlibat dalam projek yang berjalan. Tidak hanya berhenti pada proses produksi obat, namun sistem juga meliputi informasi penyimpanan obatÂ produksi ke gudang. Dengan penerapan Sistem Informasi Monitoring diharapkan perusahaan mampu memantau segala kegiatan informasi dalam proses produksi obat dan penyimpanan obat dalam gudang, sehingga proses tersebut dapat dilakukan secara sistem.
Pengembangan Sistem Informasi E-Lelang Kendaraan Motor Second Pada FIF Group Kota Bandar Lampung
Authors: . Sukatmi , Maulana Sidiq Moch Irvan 
Published: November 2021

Abstract-Â FIF group is one of company that moves in financing motor vehicle in the city Bandar Lampung .One of the activities done by FIF group is conducts an auction motor second .To bid process are needed a system information based information technology .The object is to expanding access auction which makes it easy for those interested in to follow auction motor second in FIF group city Bandar Lampung .Â E-lelang information system second a motor vehicle developed with the methods eXtream program. Used is a design usecase diagram, class diagram and activity diagram. Programming language used to auction development application in adobe dreameweaver, HTML MySQL databaseÂ Â support.Â The end result of development this is a system e-lelang a motor vehicle second in FIF group city Bandar Lampung. With the system e-lelang will ease the FIF in doing bid process and will facilitate the public or company want to join the an auction in the end would increase performance parties FIF group city Bandar Lampung .Â Â Â ABSTRACTadjektiva: abstract, notional, noetic
Pengembangan Media Komik Interaktif Cerita Mbojo Berbasis Gerakan Literasi Sekolah untuk Meningkatkan Minat Baca Siswa
Authors: Fatimah Nunung , Ningsyih Surya 
Published: November 2021

Reading is part of literacy in the lower grades carried out at school. At the elementary school level, literacy activities are the starting point for understanding other sciences. The success of the early stages is crucial for advancing to the next level. Effective literacy teaching in the early grades needs to pay attention to the learning environment and materials that suit the needs of students so that researchers are interested in conducting development research in this study specifically for low-grade students and for the place of research that is carried out at SDN Sari Kalampa. The development of interactive comic media for the Mbojo story based on the school literacy movement to increase students' reading interest carried out at SDN Sari Kalampa, Woha District, Bima Regency is very necessary. The purpose of this study is to find out the importance of using or developing a comic medium for the Mbojo story where this media will be reading material that aims to increase literacy activities. The results showed that the learning media for interactive comics based on the mbojo story based on the school literacy movement could increase students' reading interest with the average score of student responses being which was included in the "very good" category and the teacher's response was which meant the "very good" category.