bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating dissemination of scientific information on Twitter: A study of topic networks in opioid publications
Authors: Haunschild Robin , Bornmann Lutz , Potnis Devendra , Tahamtan Iman 
Published: November 2021

Abstract
While previous research has mostly focused on the “number of mentions” of scientific research on social media, the current study applies “topic networks” to measure public attention to scientific research on Twitter. Topic networks are the networks of co-occurring author keywords in scholarly publications and networks of co-occurring hashtags in the tweets mentioning those publications. We investigate which topics in opioid scholarly publications have received public attention on Twitter. Additionally, we investigate whether the topic networks generated from the publications tweeted by all accounts (bot and nonbot accounts) differ from those generated by nonbot accounts. Our analysis is based on a set of opioid publications from 2011 to 2019 and the tweets associated with them. Results indicated that Twitter users have mostly used generic terms to discuss opioid publications, such as “Pain,” “Addiction,” “Analgesics,” “Abuse,” “Overdose,” and “Disorders.” A considerable amount of tweets is produced by accounts that were identified as automated social media accounts, known as bots. There was a substantial overlap between the topic networks based on the tweets by all accounts (bot and nonbot accounts). This result indicates that it might not be necessary to exclude bot accounts for generating topic networks as they have a negligible impact on the results. This study provided some preliminary evidence that scholarly publications have a network agenda-setting effect on Twitter.
Towards establishing a research lineage via identification of significant citations
Authors: Ghosal Tirthankar , Tiwary Piyush , Patton Robert , Stahl Christopher 
Published: November 2021

Abstract
Finding the lineage of a research topic is crucial for understanding the prior state of the art and advancing scientific displacement. The deluge of scholarly articles makes it difficult to locate the most relevant previous work. It causes researchers to spend a considerable amount of time building up their literature list. Citations play a crucial role in discovering relevant literature. However, not all citations are created equal. The majority of the citations that a paper receives provide contextual and background information to the citing papers. In those cases, the cited paper is not central to the theme of citing papers. However, some papers build upon a given paper and further the research frontier. In those cases, the concerned cited paper plays a pivotal role in the citing paper. Hence, the nature of the citation that the former receives from the latter is significant. In this work, we discuss our investigations towards discovering significant citations of a given paper. We further show how we can leverage significant citations to build a research lineage via a significant citation graph. We demonstrate the efficacy of our idea with two real-life case studies. Our experiments yield promising results with respect to the current state of the art in classifying significant citations, outperforming the earlier ones by a relative margin of 20 points in terms of precision. We hypothesize that such an automated system can facilitate relevant literature discovery and help identify knowledge flow for a particular category of papers.
Beyond Gridlock: How Global Governance Continues to Shape our World
Authors: Dingwerth Klaus 
Published: November 2021

Abstract
In 2013, Thomas Hale, the late David Held and Kevin Young published Gridlock. Their book made sense of a widely shared perception. The edifice of global governance, this perception suggested, had begun to crumble under a range of pressures. The empirical evidence that lay beneath this perception was puzzling not only in a normative, but also in an analytical sense. It did not seem to match the demand for international institutions, which was the most central factor scholars pointed to when they had to explain the emergence, changes and effects of international institutions. The subtitle of Hale, Held and Young’s neatly summarised what was at stake. What had to be explained was ‘why global cooperation is failing when we need it most’. The three titles reviewed in this essay challenge this view. They suggest that many international organisations continue to do their everyday work (Dolowitz et al.), that many informal global governance institutions have been added (Roger), and that various forms of ‘ebb and flow’ have been a constant in global governance since 1850 (Grigorescu).
Detailed Tables from the Dutch Census 1947: Experiences and Lessons Learned in Publishing a Large Dataset
Authors: Jonker Jan , Poot Wouter , Doorn Peter 
Published: November 2021

Abstract
Since the end of the nineties, Dutch census publications have been digitized and made available for digital processing. New analyses of the data were presented in some fruitful conferences in the first decade of this century. In addition to the census publications, a mass of detailed census data was found in dossiers and so-called “transparencies” in the archive of Statistics Netherlands. Most of that material was scanned into digital images, awaiting further content conversion into numeric data. In the present article, the authors describe the process of digitizing the detailed tables of the Dutch Population and Occupational Censuses held in 1947, which is the first set of detailed census data that is made available in a digitally processible form. They give an example of historical analyses made possible by this dataset. Moreover, they take these census data as an example of preparing and publishing a large dataset. Experiences and lessons learned in the process lead to ample opportunities for further analysis of the data and for efficient ways to accomplish the content conversion of the many remaining images of census data.
Factors that Predict Survival From Mesenteric Ischemia in the Geriatric Patient: Not a Death Sentence
Authors: Gebran Anthony , Gallastegi Ander Dorken , Fagenholz Peter , King David , Kaafarani Haytham M. A. , Paranjape Charu , Velmahos George C. , Hwabejire John O. 
Published: November 2021

Background The mortality rate from mesenteric ischemia is reported to be as high as 80%. The goal of our study was to identify demographic and clinical predictors of post-operative mortality and discharge disposition among elderly patients with mesenteric ischemia. Methods All patients 65 years and older who underwent emergency surgery (ES) for the management of mesenteric ischemia in the American College of Surgeons–National Surgical Quality Improvement Program database from 2007 to 2017 were included. Univariate analyses and logistic regressions were used to identify independent predictors of mortality and discharge disposition. Results A total of 2438 patients met inclusion criteria, with a median age of 77 years and 60.8% being female. The 30-day mortality of the overall cohort was 31.5% and the 30-day morbidity was 65.3%. The following were the major predictors of 30-day mortality: pre-operative diagnosis of septic shock [OR: 2.46, (95% CI: 1.94-3.13)], dialysis dependence [OR: 2.05, (95% CI: 1.45-2.90)], recent weight loss [OR: 1.80, (95% CI: 1.16-2.79)], age ≥80 years [OR: 1.67, (95% CI: 1.25-2.23)], and ventilator dependence [OR: 1.65, (95% CI: 1.23-2.23)]. In the absence of these predictors, survival rate was 84%. The major predictors of discharge to post-acute care (PAC) included age ≥80 years [OR: 3.70, (95% CI: 2.50-5.47)] and pre-operative septic shock [OR: 2.20, (95% CI: 1.42-3.41)]. Conclusion In the geriatric patient, a diagnosis of mesenteric ischemia does not equate to an automatic death sentence. The presence of certain pre-operative risk factors confers a high risk of mortality, whereas their absence is associated with a high chance of survival.
Recent Advances in Local Thermal Ablation Therapy for Hepatocellular Carcinoma
Authors: Deng Min , Li Shao-Hua , Guo Rong-Ping 
Published: November 2021

Image-guided local thermal ablation (LTA) plays an important role in the treatment of hepatocellular carcinoma (HCC), especially in patients with HCC who are not suitable for hepatectomy. Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most widely used LTA clinically. Radiofrequency ablation can achieve the best result; that is, a similar therapeutic effect as hepatectomy if the tumor ≤3 cm, while MWA can effectively ablate tumors ≤5 cm. Local thermal ablation has an advantage over liver resection in terms of minimally invasive surgery and can achieve a comparable prognosis and efficacy to liver resection. For borderline liver function, selecting LTA as the first-line therapy may bring more benefits to patients with cirrhosis background. In addition, a combination of multiple therapies for HCC is a good choice, such as LTA combined with transcatheter arterial chemoembolization (TACE), which can achieve a better prognosis than single therapy for larger tumors. For patients who are awaiting liver transplantation, LTA is a good choice. The main problem of LTA needed to be solved is to prevent the local tumor recurrence after ablation in patients with HCC.
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart
Authors: Chen Zhanglin , Zhou Zuoqiong , Peng Xiyang , Sun Chenchen , Yang Dong , Li Chengli , Zhu Runkang , Zhang Ping , Zheng Lan , Tang Changfa 
Published: November 2021

AbstractHerein, we aimed to establish an aerobic exercise-induced physiological myocardial hypertrophy zebrafish (Danio rerio) model and to explore the underlying molecular mechanism. After 4 weeks of aerobic exercise, the AMR and Ucrit of the zebrafish increased and the hearts were enlarged, with thickened myocardium, an increased number of myofilament attachment points in the Z-line, and increased compaction of mitochondrial cristae. We also found that the mTOR signaling pathway, angiogenesis, mitochondrial fusion, and fission event, and mitochondrial autophagy were associated with the adaptive changes in the heart during training. In addition, the increased mRNA expression of genes related to fatty acid oxidation and antioxidation suggested that the switch of energy metabolism and the maintenance of mitochondrial homeostasis induced cardiac physiological changes. Therefore, the zebrafish heart physiological hypertrophy model constructed in this study can be helpful in investigating the cardioprotective mechanisms in response to aerobic exercise.
Dimethyl itaconate alleviates the pyroptosis of macrophages through oxidative stress
Authors: Huang Shan-Shan , Guo Dong-Yang , Jia Bing-Bing , Cai Guo-Long , Yan Jing , Lu Yan , Yang Zhou-Xin 
Published: November 2021

AbstractMacrophages are involved in the pathophysiology of many diseases as critical cells of the innate immune system. Pyroptosis is a form of macrophage death that induces cytokinesis of phagocytic substances in the macrophages, thereby defending against infection. Dimethyl itaconate (DI) is an analog of itaconic acid with anti-inflammatory effects. However, the effect of dimethyl itaconate on macrophage pyroptosis has not been elucidated clearly. Thus, the present study aimed to analyze the effect of DI treatment on a macrophage pyroptosis model (Lipopolysaccharide, LPS + Adenosine Triphosphate, ATP). The results showed that 0.25 mM DI ameliorated macrophage pyroptosis and downregulated interleukin (IL)-1β expression. Then, real-time quantitative polymerase chain reaction (RT-qPCR) was used to confirm the result of RNA-sequencing of the upregulated oxidative stress-related genes (GclcandGss) and downregulated inflammation-related genes (IL-12βandIL-1β). In addition, Gene Ontology (GO) enrichment analysis showed that differential genes were associated with transcript levels and DNA replication. Kyoto encyclopedia of genes and genomes (KEGG) enrichment showed that signaling pathways, such as tumor necrosis factor (TNF), Jak, Toll-like receptor and IL-17, were altered after DI treatment. N-acetyl-L-cysteine (NAC) reversed the DI effect on the LPS + ATP-induced macrophage pyroptosis and upregulated the IL-1β expression. Oxidative stress-related protein Nrf2 is involved in the DI regulation of macrophage pyroptosis. Taken together, these findings suggested that DI alleviates the pyroptosis of macrophages through oxidative stress.
Impact of nanophos in agriculture to improve functional bacterial community and crop productivity
Authors: Chaudhary Parul , Chaudhary Anuj , Parveen Heena , Rani Alka , Kumar Govind , Kumar Rajeew , Sharma Anita 
Published: November 2021

Abstract
Background
Since the World’s population is increasing, it’s critical to boost agricultural productivity to meet the rising demand for food and reduce poverty. Fertilizers are widely used in traditional agricultural methods to improve crop yield, but they have a number of negative environmental consequences such as nutrient losses, decrease fertility and polluted water and air. Researchers have been focusing on alternative crop fertilizers mechanisms to address these issues in recent years and nanobiofertilizers have frequently been suggested. “Nanophos” is a biofertilizer and contains phosphate-solubilising bacteria that solubilises insoluble phosphate and makes it available to the plants for improved growth and productivity as well as maintain soil health. This study evaluated the impact of nanophos on the growth and development of maize plants and its rhizospheric microbial community such as NPK solubilising microbes, soil enzyme activities and soil protein under field condition after 20, 40 and 60 days in randomized block design.

Results
Maize seeds treated with nanophos showed improvement in germination of seeds, plant height, number of leaves, photosynthetic pigments, total sugar and protein level over control. A higher activity of phenol, flavonoid, antioxidant activities and yield were noticed in nanophos treated plants over control. Positive shift in total bacterial count, nitrogen fixing bacteria, phosphate and potassium solubilizers were observed in the presence of nanophos as compared to control. Soil enzyme activities were significantly (P < 0.05) improved in treated soil and showed moderately correlation between treatments estimated using Spearman rank correlation test. Real time PCR and total soil protein content analysis showed enhanced microbial population in nanophos treated soil. Obtained results showed that nanophos improved the soil microbial population and thus improved the plant growth and productivity.

Conclusion
The study concluded a stimulating effect of nanophos on Zea mays health and productivity and indicates good response towards total bacterial, NPK solubilising bacteria, soil enzymes, soil protein which equally showed positive response towards soil nutrient status. It can be a potential way to boost soil nutrient use efficiency and can be a better alternative to fertilizers used in the agriculture.
Measuring therapeutic engagement in acute mental health inpatient environments: the perspectives of service users and mental health nurses
Authors: Chambers M. , McAndrew S. , Nolan F. , Thomas B. , Watts P. , Kantaris X. 
Published: November 2021

Abstract
Background
A key component of caring for service users (SUs) in acute mental health inpatient environments is Therapeutic Engagement (TE). To that end, the Therapeutic Engagement Questionnaire (TEQ) was developed and validated. The TEQ measures TE between SUs and registered mental health nurses (RMHNs) from the perspective of both parties and can quantify and recognise how nurses engage with SUs and monitor this activity as well as its enhancement of SU care and recovery. The aim of this study was to explore the views of SUs and RMHNs in relation to the TEQ and how it could be adopted into clinical practice within an acute inpatient environment.

Methods
As part of the validation stage of the development of the TEQ, the views of 628 SUs and 543 RMHNs were collected using a qualitative approach by way of free text at the end of the questionnaire. Two questions required free text response: – ‘what do you think of the TEQ?’, and ‘how can it be utilised?’

Results
Following thematic analysis, it was found that both sets of participants stated that such a tool could be utilised to improve the service, could help nurses with reflective practice, be utilised as part of clinical supervision and to aid nurses’ professional development. The nurse participants also stated that such a tool would help track SU participation and enablement in their care. Furthermore, the nurses noted that the tool would help to reinforce the core ‘caring’ value of nursing and the overall goal of recovery. The SUs added that the TEQ would recognise the work of mental health nurses and provide them with a clear opportunity to express their views in relation to nursing staff.

Conclusions
Therapeutic engagement (TE) has been identified as part of the repertoire of mental health nursing and both groups of participants identified how a tool to assess this construct may be utilised in day-to-day clinical practice to the benefit of each group.
Congenital midureteral stenosis in children: a 13-year retrospective study based on data from a large pediatric medical center
Authors: Meng Zhaoyi , Lin Defu , Wang Guannan , Qu Yanchao , Sun Ning 
Published: November 2021

Abstract
Background
Midureteral stenosis is very rare in children and can cause congenital hydronephrosis. We report our experience treating children with congenital midureteral stenosis at our center, focusing on the differences in preoperative diagnosis and treatment compared with other congenital obstructive uropathies.

Methods
We retrospectively reviewed the medical records of 26 children diagnosed with congenital midureteral stenosis at our center between January 2007 and December 2020, such as preoperative examination methods, intraoperative conditions, and postoperative follow-up results.

Results
Of the 1625 children treated surgically for ureteral narrowing, only 26 (1.6%) were diagnosed with midureteral stenosis, including 15 infants and 11 children. Eighteen (69.2%) were boys, 13 (50%) were affected on the left side, and 23 (88.5%) had isolated ureteral stenosis. Overall, 13 (50%) of the children presented with prenatal hydronephrosis, and 13 (50%) presented with abdominal pain or a mass. All the children had undergone urinary ultrasound and intravenous urography preoperatively; the diagnostic rate of ultrasound was 92.3%. Only 7 (26.9%) children had undergone pyelography. All the children had undergone surgery. The ureteral stenotic segment was less than 1 cm long in 25 (96.2)% of the children. The mean follow-up duration was 22 months (range: 6–50 months). One child developed anastomotic strictures. Urinary tract obstruction was relieved in the other children without long-term complications.

Conclusions
Congenital midureteral stenosis is rare, accounting for 1.6% of all ureteral obstructions, and its diagnosis is crucial. Urinary ultrasound has a high diagnostic rate and should be the first choice for midureteral stenosis. Retrograde pyelography can be used when the diagnosis is difficult, but routine retrograde pyelography is not recommended. Congenital ureteral stenosis has a relatively short lesion range, largely within 1 cm. The treatment is mainly resection of the stenotic segment and end-to-end ureteral anastomosis, with a good prognosis.
Effects of health-promoting school strategy on dental plaque control and preventive behaviors in schoolchildren in high-caries, rural areas of Taiwan: a quasi-experimental design
Authors: Wei Chun-Ting , Lo Kai-Yang , Lin Yi-Ching , Hu Chih-Yang , Chen Fu-Li , Huang Hsiao-Ling 
Published: November 2021

Abstract
Background
We evaluated the effects of health-promoting school (HPS) strategy on plaque control and behavior change in high-caries schoolchildren in Taitung, Taiwan.

Methods
A quasi-experimental design was adopted; six intervention schools (intervention group [IG]) and six comparison schools (comparison group [CG]) were selected from elementary schools with higher-than-average caries rates (> 68%). The IG was selected using cluster sampling, and the CG was selected to match the IG. In total, the IG and CG groups included 166 and 174 children each. The selected schools implemented the HPS framework for 3 months in the 2019 academic year. An oral examination of dental plaque was administered, and a self-administered questionnaire regarding knowledge, attitude, self-efficacy, and behaviors was distributed at baseline and at 2-week follow-up. A linear and logistic regression model using generalized estimating equations (GEEs) was used to analyze the differences between baseline and the follow-up data.

Results
Compared with the CG, the IG had a greater reduction in plaque index among second graders (β =  − 0.36) and plaque control record scores among second, fourth, and sixth graders (β =  − 27.48, − 26.04, and − 18.38, respectively). The IG also exhibited a greater increase at follow-up with respect to oral health–related knowledge among second graders and fourth graders (β = 1.46 and β = 0.92, respectively), attitude toward oral hygiene behaviors among sixth graders (β = 1.78), and self-efficacy regarding flossing for sixth graders (β = 1.43). Sixth graders in the IG were significantly more likely to brush before sleeping (adjusted odds ratio [aOR] = 2.99) and use fluoride toothpaste (aOR = 5.88) than those in the CG.

Conclusions
The HPS strategy was effective in reducing dental plaque and promoting preventing behaviors in rural high-caries schoolchildren.