bluuebunny/crossref_metadata_2025_split huggingface dataset:
Botulinum toxin and hyaluronic acid — the most common facial aesthetic medicine treatments — the economic aspect in terms of price in 2019 in Poland
Authors: Tomaszewski Mateusz 
Published: February 2021

Introduction. The observed intensive quantitative growth of aesthetic medicine clinics on the market may lead to a lowering of the general price level, although nowadays the high quality of services is a factor that determines the choice of a surgery more often than a low price.Aim. Estimate of average prices of selected facial aesthetic medicine’s procedures in Poland in 2019.Material and Methods. 7 types of facial aesthetic medicine treatments with the use of botulinum toxin or fillers that were used in 112 clinics located in Poland in 2019 were taken for the analysis.Results. The highest prices for wrinkle reduction with botulinum toxin were in the Mazowieckie Voivodeship and the lowest in the Podlasie Voivodeship. Treatments with the use of fillers cost the least in Kuyavian-Pomeranian, and the most in Mazowieckie. The most expensive treatment among the examined was the correction of the shape of the lips - 910 PLN and the cheapest was the reduction of wrinkles around the eyes - 460 PLN.Discussion. Higher prices than average can be expected in provincial cities. This is often dictated by the level of service innovation and / or patient wealth. Sometimes offering lower prices than the average can be an effective way to attract customers.Results. Treatments with the use of fillers are more expensive than those with the use of botulinum toxin by almost half. Most surgeries offer services in the field of facial aesthetic medicine using botulinum toxin and / or fillers at comparable prices.
Platelet‑rich plasma as a method of treatment of androgenetic alopecia in men — a case report
Authors: Przybylska Patrycja , Matthews‑Brzozowska Teresa 
Published: February 2021

Androgenetic alopecia is a common condition, accounting for about 95% of all male hair loss. Standard therapeutic solutions recommend the use of minoxidil, finasteride, spironolactone, nutritional supplementation, phototherapy and hair transplant surgery. An increasingly popular alternative method that has been used in the case report is platelet rich plasma (PRP) mesotherapy characterized by autologous character, minimal invasiveness and no serious side effects. A series of 3 treatments was performed at 3-week intervals. The effects of using medical photographic documentation after completing a series of treatments.
The Prediction of Plankton Diversity and Abundance in Mangrove Ecosystem
Authors: Hilmi Endang , Sari Lilik Kartika , Amron Amron 
Published: February 2021

The abundance of phytoplankton and zooplankton have correlation with mangrove conditions in coastal area. The mangrove degradation give negative impact for abundance and diversity phytoplankton and zooplankton. The research aimed to analysis and construct prediction model of abundance and biodiversity of phytoplankton and zooplankton in mangrove ecosystem. The research used the transect method (to determine mangrove density), filtering method (to analyze abundance of phytoplankton and zoopankton) and statistical method (to develop estimation modeling of plankton abundance). The results showed that (1) the mangrove density between 250 trees/Ha - 1250 trees/Ha (2) the phytoplankton abundance were 10.675 Indv/L (in mangrove rarely) - 24.290 indv/ L (in mangrove high density), (3) the zooplankton abundance were 261 Indv/L (in mangrove rarely) - 2.204 indv/L (in mangrove high density) (4) The modelling analysis showed that (1) the phytoplankton abundance (y) = 0.0303 x2 - 22.059 x + 13004 and (2) the zooplankton abundance (y) = 0.0057x2 – 5.39 x + 1458.2, with x = mangrove densityKeywords: phytoplankton and zooplankton, mangrove density, abundance, estuary and lagoon
Comparison of Simulated and Observed Current Velocities in Karimata and Gaspar Straits
Authors: Trenggono Mukti , Priyono Bayu , Hidayat Rizqi Rizaldi , Agustiadi Teguh 
Published: February 2021

Karimata and Gaspar Straits were the connector between the South China Sea and Indonesian Seas, which played a role in transporting the Indonesian Through Flow. The current velocities in both straits were studied by comparing outputs from the INDO12 physical ocean model simulation against observation results from the South China Sea-Indonesian Seas Transport Exchange (SITE) program. In general, the magnitudes of the zonal and meridional model current velocities are weaker than observations. Notably, the B1 and B4 moorings show uncertain model values most of the time. It is understandable considering that B1 and B4 moorings are located in a narrow strait (Gaspar Strait), near the coasts. On the contrary, B2 and B3 moorings show comparable magnitude to the two zonal and meridional components' observations Keywords: Karimata Strait, Current Velocities, INDO12, SITE Program
Penentuan Pelarut untuk Adsorpsi Oryzanol dari Minyak Bekatul dengan Investigasi Kromatografi Lapis Tipis (Thin Layer Chromatography)
Authors: Susanti Ari Diana , Sediawan Wahyudi Budi , Wirawan Sang Kompiang , Budhijanto Budhijanto 
Published: February 2021

<p>Oryzanol yang terkandung dalam minyak bekatul mempunyai kekuatan antioksidan lebih tinggi daripada vitamin E dan terbukti mempunyai efek hipokolesteromik sehingga berguna untuk kesehatan jantung dan pembuluh darah. Metode adsorpsi menggunakan adsorben silika merupakan salah satu metode isolasi oryzanol yang menjanjikan. Keberhasilan proses pemungutan oryzanol sangat ditentukan oleh pemilihan pelarut yang digunakan karena oryzanol merupakan senyawa ester sehingga sifatnya mirip dengan sifat trigliserida minyak bekatul yang ingin dipisahkan darinya. Oleh karena itu perlu ditentukan pemodifikasi pelarut sehingga diperoleh campuran pelarut yang cocok untuk proses tersebut. Modifikasi dilakukan terhadap pelarut utama n-heksana dan pemodifikasi potensial yang digunakan adalah etil asetat, diklorometana, kloroform, dan aseton. Performa campuran pelarut diuji menggunakan metode kromatografi lapis tipis (<em>thin layer chromatography </em>- <em>TLC</em>) menggunakan plat TLC silika gel grade 60. Hasil penelitian menunjukkan kombinasi n-heksana/aseton = 85/15 memberikan hasil pemisahan oryzanol terbaik, sedangkan kombinasi n-heksana/etil asetat = 90/10 patut dipertimbangkan apabila elusi secara gradien dipilih dalam proses pemisahan.</p>
Lilin Aromaterapi dari Minyak Atsiri Kulit Jeruk Manis (Citrus sinensis)
Authors: Lestari Defe , Vidayanti Eva , Jumari Arif 
Published: February 2021

<p><strong>Abstrak.</strong><strong> </strong>Kulit jeruk manis saat ini hanya menjadi sampah yang belum banyak termanfaatkan. Ada senyawa kimia minyak atsiri bernilai ekonomi tinggi pada kulit jeruk yang disebut limonene yang memiliki aroma segar yang khas. Minyak atsiri Limonene diekstrak dari kulit jeruk kemudian diaplikasikan sebagai lilin aromaterapi. Pengambilan minyak atsiri menggunakan destilasi uap cair selama 3 jam. Setelah itu, minyak esensial ditambahkan ke lilin aromaterapi dan asam stearat. Volume minyak atsiri hasil destilasi pada penelitian ini adalah 2,3 mL dengan berat 1,957 gram dari 200 gram kulit jeruk. Penambahan minyak atsiri sebanyak 3 mL untuk sampel 1 dan 5 mL untuk sampel 2. Lilin aromaterapi telah diuji lama nyala api dan penerimaan produk di masyarakat. Hasil penelitian menunjukkan bahwa semakin tinggi kandungan Minyak Atsiri Limonene semakin lama durasi nyala api dan semakin tinggi penerimaannya di masyarakat.</p><p><strong> </strong></p><p><strong>Abstract.</strong> Sweet orange peel is a waste. There is a high economic valued chemical compound of essential oil called limonene which has a distinctive fresh aroma. Essential oil of Limonene was extracted from orange peel then will be applied as aromatherapy candles. The taking of essential oils is using distillation of liquid vapor for 3 hours. After that, the essential oil is added to aromatherapy wax and stearic acid. The volume of essential oil extracted from distillation in this study is 2,3 mL with weight 1.957 grams from 200 grams of orange peel. The addition of essential oil is 3 mL for sample 1 and 5 mL for sample 2.. The aromatherapy candles had tested for flame duration and product acceptance in the community. The result showed that the higher the content of Essential oil of Limonene the longer the flame duration and the higher the acceptance in the community.</p><p> </p><p><strong>Keyword</strong> : sweet orange peel, essential oil of Limonene, extraction, distillation, aromatherapy candle,</p>
Inventarisasi tumbuhan family Asteraceae dan Araceae di Situ Agathis, Universitas Indonesia, Depok, Jawa Barat
Authors: Shafyra Ia Refyta , Jayanti Yulianita Tri , Ersita Visdha , Chandrika Ni Luh , Fatwa Anggun Wening , Heryanti Erna , Wulaningsih Ratna Dewi 
Published: February 2021

Situ Agathis merupakan salah satu dari enam situ yang menerima aliran air pertama ke wilayah Universitas Indonesia (UI), Depok, Jawa Barat yang memiliki fungsi ekologis sebagai penyangga bagi ekosistem teresterial dan akuatik, di daerah tersebut banyak ditumbuhi berbagai jenis tumbuhan yang seringkali dipengaruhi oleh genangan air. Famili Asteraceae dan Araceae adalah 2 contoh famili yang tumbuh di daerah sempadan Situ Agathis, Universitas Indonesia. Situ Agathis terletak pada daerah urban padat penduduk, akibatnya ekosistem Situ Agathis telah rusak karena banyaknya sampah dan limbah rumah tangga yang dibuang ke aliran sungai lalu mengalir ke Situ Agathis. Dalam hal ini peneliti melakukan studi inventarisasi tumbuhan dari Family Araceae dan Asteraceae yang ada di Situ Agathis, Universitas Indonesia. Metode yang digunakan ialah metode deskriptif dengan pengambilan data menggunakan line transect di 3 lokasi,dimulai dari tepi bagian kanan situ, bagian tengah situ, dan tepi bagian kiri situ dan didapatkan spesies paling banyak ditemukan adalah Colocasia esculenta dari Famili Aracaeae. Famili Araceae yang ditemukan di Situ Agathis berdampak baik bagi lingkungan karena dapat dijadikan sebagai fitoremediasi dalam mempengaruhi kualitas air limbah yang tercemar di kawasan tersebut.
Favorable Lip and Oral Cancer Mortality-To-Incidence Ratios in Countries With High Human Development Index and Expenditures On Health
Authors: Sung Wen-Wei , Hsu Yong-Chen , Chen Ying-Ching , Chao Yu-Chi , Chen Chih-Jung 
Published: February 2021

Abstract

Background: The incidence rate of lip and oral cancer is increasing in recent years, the prognosis of which is associated with a country’s socioeconomic status. The mortality-to-incidence ratio (MIR) is a reasonable indicator of disparities in cancer screening and treatment. We aim to understand the association between economic status and cancer prognosis.Methods: Data were obtained from the Global Cancer Observatory (GLOBOCAN) and the World Health Organization (WHO). The MIR was applied to evaluate the correlation to healthcare expenditures and the human development index (HDI) disparities via Spearman's rank correlation coefficient.Results: The results showed that Asia has the most cases and deaths. The association of the HDI, current health expenditure (CHE), and ratio of CHE to the percentage of gross domestic product (CHE/GDP) to the crude rate (CR) of incidence show significant results (p<0.001, p=0.005, and p<0.001, respectively). However, their association with the mortality rate (p=0.303, p=0.997, and p=0.101) is not significant. In the correlation of the MIRs, the results revealed a significant association with the HDI, CHE, and CHE/GDP with the MIR (p<0.001, p<0.001, and p<0.001, respectively).Conclusion: Countries with a higher HDI, more CHE per capita, and higher CHE/GDP tend to have a lower MIR, which indicates a favorable clinical outcome.
Prolonged Carriage of ESBL-producing Enterobacteriaceae and Potential Cross-transmission among Residents in Geriatric Long-term Care Facilities
Authors: Ae Ryusuke , Sasahara Teppei , Yoshimura Akio , Kosami Koki , Hatakeyama Shuji , Sasaki Kazumasa , Kimura Yumiko , Akine Dai , Ogawa Masanori , Hamabata Kenji , Cui Longzhu 
Published: February 2021

Abstract
Background: Previous studies indicated residents in geriatric long-term care facilities (LTCFs) had much higher prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) carriage than the general population. Most ESBL-E carriers are asymptomatic. The study tested the hypothesis that residents with ESBL-E carriage may accumulate inside geriatric LTCFs through potential cross-transmission after exposure to residents with prolonged ESBL-E carriage.Methods: We evaluated 260 residents receiving long-term care in four LTCFs in Japan. All residents underwent initial ESBL-E testing of fecal specimens and were divided into two cohorts: Cohort 1, 95 patients with ≥2 months residence at study onset; Cohort 2, 165 patients with <2 months residence at study onset or new admission during the study period. Among the 260 residents with continuous LTCF residence, 126 underwent second testing 3–12 months after the first testing and 36 residents underwent third testing ≥12 months after the second testing. Three analyses were performed: (1) ESBL-E carriage statuses in Cohort 1 and Cohort 2; (2) changes in ESBL-E carriage statuses in the second testing and third testing; and (3) lengths of positive ESBL-E carriage statuses in patients who underwent the second testing and third testing.Results: Among all 260 residents, 95 (36.5%) were positive for ESBL-E carriage in the first testing. The prevalence of ESBL-E carriage was significantly higher in Cohort 2 than in Cohort 1 (40% vs. 28%; p<0.01). In the subsequent testing results, 18.3% of residents who were negative in the first testing showed positive conversion to ESBL-E carriage in the second testing, while no patients who were negative in the second testing showed positive conversion in the third testing. The maximum length of ESBL-E carriage was 17 months.Conclusions: ESBL-E was most likely to be carried into LTCFs through admission of new residents. Some residents acquired ESBL-E through potential cross-transmission within 3–12 months after admission. Despite possible ESBL-E carriage for >1 year, no residents showed positive conversion >12 months after admission, which suggests that residents with ESBL-E carriage may not accumulate inside LTCFs. Practical infection control and prevention measures against ESBL-E by care providers could improve the ESBL-E prevalence in geriatric LTCFs.
Radiosynthesis of A Novel Antisense Imaging Probe Targeting LncRNA HOTAIR in Malignant Glioma.
Authors: Ren Jiongyu , Zhang Xiyuan , Cao Jiang , Tian Jiali , Luo Jin , Yu Yaping , Wang Fengkui , Li Jiamiao , Zhao Qian 
Published: February 2021

Abstract
Background: Long non-coding RNA (lncRNA) HOTAIR was manifested overexpressing and amplifying in many human carcinomas, which could serve as a useful target for cancer therapy. The 99mTc radiolabeled antisense oligonucleotides (ASON) could visualize the expression of HOTAIR and provide a diagnostic and therapeutic value for malignant tumors. The aim of this study was to radiosynthesis 99mTc with HOTAIR ASON and investigate the in vivo imaging in malignant glioma xenografts. Methods: The ASON targeting lncRNA HOTAIR as well as mismatched ASON probe (ASONM) were designed and modified. The radiolabeling of 99mTc with two probes was via the conjugation of bifunctional chelator HYNIC. Then the probes were purified by Sephadex G25 and tested for its radiolabeling efficiency and purity, as well as stability by iTLC and gel electrophoresis. Then the radiolabeled probes were transfected with lipofectamine 2000 for cellular uptake test and the next experimental use. Furthermore, biodistribution study and SPECT imaging was performed at different time after probes were intravenously injected in U87 tumor bearing nude mice models. All data were analyzed by statistical software. Results: The labeling efficiencies of 99mTc-HYNIC-ASON and 99mTc-HYNIC-ASONM measured by iTLC were (91 ±1.5) % and (90 ±0.6) %, respectively, and the radiochemical purity were more than 89%. The probes showed good stability within 12 hours for high radiochemical purity. Gel electrophoresis confirmed that the oligomers were successfully radiolabeled no significant degradation were found. Cellular uptake experiment showed that liposomes had ability to carry probes into cells. Biodistribution study demonstrated that liposome coated 99mTc-HYNIC-ASON had significantly higher uptake in the tumor and higher tumor to muscle ratio than mismatched group. Meanwhile tumor was clearly shown at 1 hours post probe injection of Liposome coated 99mTc-HYNIC-ASON on SPECT/CT imaging, compared with mismatched and blocking group. Conclusion: The Liposome encapsulated 99mTc-HYNIC-ASON probe can be radiosynthesized and used in the in vivo, real-time imaging of lncRNA HOTAIR expression in malignant glioma.
Air Pollution Associated Dry Eye Disease May Be Increased by Qi Stagnation in Young: A Nested Case-Control Study in Liaoning, China
Authors: Yu Fei , Ren Zhongjuan , Song Wei , Yan Chunhong , Li Jing , Yu Cui , He Xingru , Hao Wei 
Published: February 2021

Abstract
Background: Little information exists regarding the interaction of Qi stagnation and air pollution on young’s dry eye disease (DED) in fixed area with an epidemic threat. The aim of this study is to assess the modification by Qi stagnation on the associations of exposure with DED in Chinese young. Methods: A nested case-control study was conducted in Chinese young population aged 17-20 years, within a cohort of He Eye Health screening project. All cases newly diagnosed (n = 576) were matched to controls (n = 576) by age and sex. Logistic regression model was used to assess the odds ratio (OR) and 95% confidence interval (CI) of DED for exposure to different air pollutants in terms of an interquartile range (IQR) increase in exposure level, adjusted for potential confounders. Results: In single-pollutant model, the DED ORs (95% CI) for the 20th to 40th percent of quintile (vs. lowest) were 2.64 (1.66, 4.18) for PM2.5, 1.70 (1.09, 2.66) for PM10, for the highest quintile (vs. lowest) were 1.74 (1.13, 2.66) for CO, and 1.57 (0.98, 2.51) NO2. In contrast, the odds ratios for the highest quintile (vs. lowest) were 0.23 (0.07, 0.78) for O3. Corresponding estimates were higher among Stagnant qi constitution [ORPM10 = 1.69 (1.08, 2.16), ORCO = 1.93 (1.19, 3.54)] than Balanced constitution [ORPM10 = 1.29 (0.79, 2.05), ORCO = 1.70 (1.09, 3.43)] for PM10 and CO2, respectively. In addition, O3 was inversely associated for Stagnant qi constitution [0.67 (0.23, 1.90)] and Balanced constitution [0.51 (0.08, 1.40)]. Conclusion: Exposure to ambient PM2.5, PM10, CO and NO2 was positively associated with DED in Chinese young population. Qi stagnation might amplify the association of exposures to PM10 and CO with DED.
Transcriptome Profiling Analysis of Muscle Tissue Reveals Potential Candidate Genes Affecting Water Holding Capacity in Chinese Simmental Beef Cattle
Authors: Du Lili , Chang Tianpeng , An Bingxing , Liang Mang , Duan Xinghai , Cai Wentao , Zhu Bo , Gao Xue , Chen Yan , Xu Lingyang , Zhang Lupei , Li Junya , Gao Huijiang 
Published: February 2021

Abstract
Water holding capacity (WHC) is an important sensory attribute that greatly influences meat quality. However, the molecular mechanism that regulates the beef WHC remains to be elucidated. In this study, the longissimus dorsi (LD) muscles of 49 Chinese Simmental beef cattle were subjected to RNA sequencing (RNA-seq), among which eight individuals with the highest WHC (H-WHC) and the lowest WHC (L-WHC) were selected for transcriptome analysis. A total of 1256 genes were identified as differentially expressed genes (DEGs) between two groups, of which 948 genes were up-regulated and 308 genes were down-regulated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment revealed that DEGs were significantly enriched in 24 GO terms and 78 pathways. Additionally, based on protein-protein interaction (PPI) network, animal QTL database (QTLdb), and relevant literature, the study not only confirmed seven genes (HSPA12A, HSPA13, PPARg, MYH10, MYL2, MYPN, and TPI1) influenced WHC in accordance with previous studies, but also identified six genes (ITGAV, FGF2, THBS1, DCN, COL4A1, and TGFBR1) as the most promising novel candidate genes affecting the WHC. These findings could offer important insight for exploring the molecular mechanism underlying the WHC trait and facilitate the improvement of beef quality.
Associations of Body Mass Index, Visceral Fat Area, Waist Circumference, and Waist-To-Hip Ratio with Cognitive Function in Western China: Results from A WCHAT Study
Authors: Liu Xiaolei , Chen Xiaoyan , Hou Lisha , Xia Xin , Hu Fengjuan , Luo Shuyue , Zhao Wanyu , Zhang Yan , Ge Meiling , Zhang Gongchang , Dong Birong 
Published: February 2021

Abstract
ObjectivesThis study examined the relationship between cognitive performance and obesity parameters, such as body mass index (BMI), visceral fat area (VFA), waist circumference (WC), and waist-to-hip ratio (WHR) in western China.Study designA cross-sectional studyMethods3914 participants, aged >50 years, were recruited in this study. Anthropometrics measurements, life-style factors, chronic disease comorbidities, and sleep qualities were recorded for each participant. Among the anthropometrics, BMP, WC, and WHR were assessed using standard procedures, while VHA was calculated using bioelectrical impedance analysis. Cognitive performance was estimated using the Short Portable Mental Status Questionnaire (SPMSQ). Finally, relationships between cognitive abilities and BMI, VFA, WC, and WHR were evaluated using univariate and multivariate regression analyses. ResultsCognitive decline (CD) occurred at a rate of 13.29% among the 3914 participants. A strong correlation was observed between cognitive abilities and BMI of male patients aged 50-59 yrs (OR 1.116,95% CI1.002-1.242), in the adjusted model. Alternately, WHR was shown to be significantly related to CD in females aged >70 years (OR 0.041, 95% CI0.002-0.671). WC was shown to have a strong association with CD in males (OR 1.023,95% CI1.003-1.024). Lastly, WHR was closely connected to CD in participants with BMI < 25 kg/m2 (OR 0.022,95% CI0.002-0.209).Conclusions Our findings suggest that a higher middle age BMI is associated with CD, whereas, in the elderly population, a higher WHR is related to improved cognitive performance. Further investigation is warranted to elucidate a relationship between VFA and CD.