bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future of total hip arthroplasty with the Metha short stem in modern surgeries
Authors: Drobniewski Marek , Synder Marek , Synder Marek Aleksander , Krasińska Magdalena , Olewnik Lukasz , Borowski Andrzej 
Published: November 2021

AbstractThe aim of the study was to analyse the results of uncemented total hip replacement, using the Metha (metaphyseal) stem. A total of 158 patients (70 females and 88 males) were qualified to the study and submitted to total hip arthroplasty (183 procedures altogether), using the Metha stem. The mean age of the patients on the day of surgery was 51.7 years (the range from 17 to 69 years). The mean follow up period was 9.2 years (the range from 5 to 13.5 years). Preoperative assessments gave poor scores, according to the Merle d’Aubigne and Postel classification, modified by Charnley. The average improvement after surgery, according to the used scale, was 6.9 points. A very good outcome was recorded in 154 cases (84.2%), a good outcome was achieved in 20 cases (10.9%) and a poor outcome was confirmed in 9 cases, while no satisfactory case was observed. Poor outcomes were associated with implant loosening. Extraskeletal ossification was noted in 10 cases (5.5%). According to the Kaplan–Meier estimator, the 10-year survival was 93.2% and 97.3% for the whole implant and the stem alone, respectively. 1. Our follow-up period of more than 9 years on the average, indicates that Metha stems produce excellent clinical and functional results in operated young patients with advanced degenerative changes of the hip joint. 2. Assuming a proper qualification for the procedure, the absence of complications and a correct surgical technique, which is slightly more difficult, when compared to standard stem implantation, the risk of aseptic loosening is fairly negligible.
Splenectomy is associated with sexual dysfunctions and decreased libido
Authors: Sabino Kelly Renata , Petroianu Andy 
Published: November 2021

AbstractThe removal of the spleen due to disease or trauma may be followed by disorders due to the asplenism, including immunodeficiency, hematological and metabolic diseases, mainly dyslipidemia, which can lead to sepsis, pulmonary embolism and early death. Although patients frequently report sexual disinterest after splenectomy, this feature has been experimentally studied only in a translational investigation performed by the same group of this work. To study libido and other sexual functions after the complete removal of the spleen in humans. This study was performed on 60 healthy adults, 30 men and 30 women, after more than 1 year of total splenectomy to treat isolated splenic trauma. The International Index of Erectile Function was applied to men and the Female Sexual Function Index to women. The analysis compared the responses obtained in the periods before and after the splenectomy. Laboratory tests with hematological and biochemical analyses, including sex hormones, were performed in all patients. The pre- and postoperative results were compared in each group using the paired t-test, with each patient being his or her own control and with significance to p < 0.05. A decrease in libido and an increase in sexual dysfunction was observed after splenectomy in all men and women, p < 0.001. All postoperative laboratory tests showed normal values in both genders. Asplenia is associated with a marked decrease in libido and intense sexual dysfunction in both men and women, with normal hematological and biochemical laboratory tests, including hormonal exams.
Effect of sutureless securement on hemodialysis catheter-related bloodstream infection
Authors: Fujimoto Keiji , Iida Emi , Kumano Syo , Fujii Ai , Adachi Hiroki , Furuichi Kengo , Yokoyama Hitoshi 
Published: November 2021

AbstractThe use of sutureless securement devices during catheterization might reduce the risk of catheter-related bloodstream infection (CRBSI) by suppressing catheter-exit infection and catheter dislodgement. However, the effectiveness of these devices in reducing CRBSI risk when securing hemodialysis catheters has not been explored. This single-center retrospective observational study examined 211 non-tunneled hemodialysis catheters (NTHCs) from 110 hemodialysis inpatients, of which 121 were secured using conventional skin sutures (Suture group) and 90 with GRIP-LOK (GRIP-LOK group). The stabilized inverse probability of treatment (SIPT)-weighting method was used to generate a new population (SIPT-weighted model) without group differences for each of the 12 predictors of CRBSI development (i.e., age, sex, dialysis history, concomitant acute kidney injury or diabetes, concurrent use of immunosuppressant drugs or aspirin, NTHC insertion site, methicillin-resistant Staphylococcus aureus, carriage, bacteremia event within 3 months before catheterization, hemoglobin level, and serum albumin titer). The effect of GRIP-LOK compared with sutures on CRBSI in the SIPT-weighted model was evaluated using univariate SIPT-weighted Cox proportional regression analysis, which showed a significant CRBSI suppression effect of GRIP-LOK compared with sutures (hazard ratio: 0.17 [95% CI 0.04–0.78], p = 0.023).　GRIP-LOK affords a lower risk of CRBSI due to indwelling NTHCs than conventional securement using sutures.
Effects of whole-body vibration training in a cachectic C26 mouse model
Authors: van der Ende Miranda , Plas Rogier L. C. , van Dijk Miriam , Dwarkasing Jvalini T. , van Gemerden Frans , Sarokhani Attusa , Swarts Hans J. M. , van Schothorst Evert M. , Grefte Sander , Witkamp Renger F. , van Norren Klaske 
Published: November 2021

AbstractTargeted exercise combined with nutritional and pharmacological strategies is commonly considered to be the most optimal strategy to reduce the development and progression of cachexia. For COPD patients, this multi-targeted treatment has shown beneficial effects. However, in many, physical activity is seriously hampered by frailty and fatigue. In the present study, effects of whole-body-vibration-training (WBV) were investigated, as potential alternative to active exercise, on body mass, muscle mass and function in tumour bearing mice. Twenty-four male CD2F1-mice (6–8 weeks, 21.5 ± 0.2 g) were stratified into four groups: control, control + WBV, C26 tumour-bearing, and C26 tumour-bearing + WBV. From day 1, whole-body-vibration was daily performed for 19 days (15 min, 45 Hz, 1.0 g acceleration). General outcome measures included body mass and composition, daily activity, blood analysis, assessments of muscle histology, function, and whole genome gene expression in m. soleus (SOL), m. extensor digitorum longus (EDL), and heart. Body mass, lean and fat mass and EDL mass were all lower in tumour bearing mice compared to controls. Except from improved contractility in SOL, no effects of vibration training were found on cachexia related general outcomes in control or tumour groups, as PCA analysis did not result in a distinction between corresponding groups. However, analysis of transcriptome data clearly revealed a distinction between tumour and trained tumour groups. WBV reduced the tumour-related effects on muscle gene expression in EDL, SOL and heart. Gene Set Enrichment Analysis showed that these effects were associated with attenuation of the upregulation of the proteasome pathway in SOL. These data suggest that WBV had minor effects on cachexia related general outcomes in the present experimental set-up, while muscle transcriptome showed changes associated with positive effects. This calls for follow-up studies applying longer treatment periods of WBV as component of a multiple-target intervention.
Electro-spinning of highly-aligned polyacrylonitrile nano-fibres with continuous spooling
Authors: Shao Siheng , Ma Tao , Fernando Gerard F. 
Published: November 2021

AbstractThis paper reports on a new configuration for producing highly-aligned electro-spun fibres that can be produced on a static substrate or one where it is hauled off and spooled continuously to enable the production of continuous lengths. The fixture consists of a Vee-shaped polytetrafluorethylene shield at 60° with a 1 cm wide integral rectangular base that is mounted on a copper disk with a 10 cm diameter. Specified concentrations of polyacrylonitrile in dimethyl sulfoxide were electro-spun on to a strip of cellulose paper. In the static setup, approximately 91% of the fibres were deposited to within 3°. When the spooling rig was used, a tape of the cellulose paper was hauled off at 0.07 mm/min, 78% of the fibres were aligned to within 3°. Simulations of the conventional and Vee-shield electro-spinning setups were undertaken and they provided corroboration for the experimental observations with regard to the mechanism responsible for fibre alignment. The feasibility of using this technique to produce 0°/− 45°/+ 45° stacked layers of aligned fibre preform is demonstrated.
Non-enzymatic colorimetric detection of hydrogen peroxide using a μPAD coupled with a machine learning-based smartphone app
Authors: Doğan Vakkas , Yüzer Elif , Kılıç Volkan , Şen Mustafa 
Published: November 2021

Here, a smartphone app named Hi-perox Sens supported by machine learning classifiers was applied to a μPAD based on an iodide-mediated TMB-H2O2 reaction system for non-enzymatic colorimetric determination of H2O2.
Phonological Profile of Patients With Velopharyngeal Dysfunction and Palatal Anomalies
Authors: Nachmani Ariela , Masalha Muhamed , Kassem Firas 
Published: November 2021

Purpose:
This purpose of this study was to assess the frequency and types of phonological process errors in patients with velopharyngeal dysfunction (VPD) and the different types of palatal anomalies.

Method:
A total of 808 nonsyndromic patients with VPD, who underwent follow-up at the Center for Cleft Palate and Craniofacial Anomalies, from 2000 to 2016 were included. Patients were stratified into four age groups and five subphenotypes of palatal anomalies: cleft lip and palate (CLP), cleft palate (CP), submucous cleft palate (SMCP), occult submucous cleft palate (OSMCP), and non-CP. Phonological processes were compared among groups.

Results:
The 808 patients ranged in age from 3 to 29 years, and 439 (54.3%) were male. Overall, 262/808 patients (32.4%) had phonological process errors; 80 (59.7%) ages 3–4 years, 98 (40, 0%) ages 4.1–6 years, 48 (24.7%) 6.1–9 years, and 36 (15.3%) 9.1–29 years.
Devoicing was the most prevalent phonological process error, found in 97 patients (12%), followed by cluster reduction in 82 (10.1%), fronting in 66 (8.2%), stopping in 45 (5.6%), final consonant deletion in 43 (5.3%), backing in 30 (3.7%), and syllable deletion and onset deletion in 13 (1.6%) patients.

No differences were found in devoicing errors between palatal anomalies, even with increasing age. Phonological processes were found in 61/138 (44.20%) with CP, 46/118 (38.1%) with SMCP, 61/188 (32.4%) with non-CP, 70/268 (26.1%) with OSMCP, and 25/96 (26.2%) with CLP. Phonological process errors were most frequent with CP and least with OSMCP (
p
= .001).

Conclusions:
Phonological process errors in nonsyndromic VPD patients remained relatively high in all age groups up to adulthood, regardless of the type of palatal anomaly. Our findings regarding the phonological skills of patients with palatal anomalies can help clarify the etiology of speech and sound disorders in VPD patients, and contribute to general phonetic and phonological studies.
High‐performance ZnO varistor ceramics prepared by arc‐induced flash sintering with low energy consumption at room temperature
Authors: Wu Angxuan , Zhu Zhixiang , Wang Xilin , Yan Nianping , Zhou Hongyang , Huang Rongxia , Ma Guoming , Jia Zhidong , Wang Liming 
Published: November 2021

AbstractThe development of ultra‐high voltage transmission lines requires a ZnO arrester with excellent electrical response and high voltage gradient. Compared with conventional preparation methods, flash sintering allows fast production of novel high‐performance ZnO varistor ceramics with low energy consumption and controlled grain growth. Herein, ZnO varistor ceramics were prepared using the flash sintering method at an air pressure of 21 kPa for 60 s at 25°C. The results showed that the flash‐sintered samples had fine grains and reduced loss of volatile elements. Moreover, the voltage gradient, leakage current density, and non‐linear coefficient of the flash‐sintered varistor ceramics were significantly improved compared with those of conventionally sintered samples. Owing to the short preparation time and absence of a heating process, the energy consumption of the proposed flash sintering method was significantly reduced to 10% of that by conventional sintering. The proposed method is a promising approach for the preparation of ZnO arresters with excellent electrical properties and serves as an effective method that realises energy saving and emission reduction.
miR-1229-3p as a Prognostic Predictor Facilitates Cell Viability, Migration, and Invasion of Hepatocellular Carcinoma
Authors: Zhang Chunhong , Zhang Qi , Li Honghai , Wu Yan 
Published: November 2021

AbstractHepatocellular carcinoma (HCC) remains one of the most prevalent human malignancies with high mortality. Increasing studies have revealed microRNAs (miRNAs) play crucial roles in the tumorigenesis and progression of cancers. The current study investigated the expression levels of miR-1229-3p and its potential role in HCC. This study enrolled 121 HCC patients. The expression of miR-1229-3p was measured using RT-qPCR in HCC tissue samples and cell lines. The association of miR-1229-3p expression with clinical parameters and patients’ prognosis was analyzed by χ2 test, Kaplan–Meier, and multivariate Cox regression analyses, respectively. The functions of miR-1229-3p in HCC cells were explored by CCK-8 assay, Transwell migration, and invasion assays. miR-1229-3p was upregulated in HCC tissue samples and cell lines. The upregulation of miR-1229-3p was related to positive lymph node metastasis and advanced TNM stages and predicted with patients’ poor prognosis. Overexpression of miR-1229-3p facilitated cell viability and metastasis of HCC cells while knockdown of miR-1229-3p suppressed cell viability and metastasis of HCC cells in vitro. miR-1229-3p may function as an oncogenic role in HCC via promoting cell viability and metastasis. Moreover, miR-1229-3p may be a predictive marker for tumor development and prognosis of HCC patients.
Octreotide-LAR is a Useful Alternative for the Management of
Diazoxide-Responsive Congenital Hyperinsulinism
Authors: Karlekar Manjiri Pramod , Sarathi Vijaya , Arya Sneha , Flanagan Sarah E. , Patil Virendra , Lila Anurag , Shah Nalini , Bandgar Tushar 
Published: November 2021

AbstractThe data on the congenital hyperinsulinism (CHI) in Asian Indian patients is
limited. Diazoxide is often unavailable in India, which poses challenge in
managing CHI. The study was aimed to present our experience with CHI with a
special focus on the effectiveness and cost-effectiveness of octreotide
long-acting release (OCT-LAR) among diazoxide-responsive CHI. The data of 14
index cases with CHI registered at our center were retrospectively analyzed. The
diagnosis of CHI was based on elevated serum insulin (3.4–32.5
μIU/ml) and C-peptide (0.58–1.98 ng/ml) at the time of
symptomatic hypoglycemia (BG≤41 mg/dl). Fourteen patients (13
males) presented at a median (range) age of 3 (1–270) days, seizures
being the most common mode of presentation (78.6%). Ten patients were
diazoxide-responsive, two were partially responsive, while two were
unresponsive. Genetics was available for eight patients; ABCC8
(n=3, 1 novel) and HADH (n=2, both novel) were the most
commonly mutated genes. OCT-LAR was offered to eight patients including four
with diazoxide-responsive disease and was universally effective. We propose a
cost-effective approach to use OCT-LAR in the management of CHI, which may also
make it more cost-effective than diazoxide for diazoxide-responsive disease.
Five of the 11 (45.5%) patients had evidence of neurological impairment;
notably, two patients with HADH mutations had intellectual disability
despite diazoxide-responsiveness. We report three novel mutations in
CHI-associated genes. We demonstrate the effectiveness of and propose a
cost-effective approach to use OCT-LAR in diazoxide-responsive CHI. Mutations in
HADH may be associated with abnormal neurodevelopmental outcomes
despite diazoxide-responsiveness.
Assessment of Plasma-Free Cortisol Concentrations by LC-MS/MS in Patients with Autonomous Cortisol Secretion
Authors: Yener Serkan , Tuna Gamze , Kant Melis , Akis Merve , Kara Ozlem , Kalas Busra , Baris Mustafa , Islekel Gul Huray 
Published: November 2021

AbstractAutonomous cortisol secretion (ACS) of an adrenal incidentaloma (AI) is associated with mild cortisol excess that could result in poor metabolic and cardiovascular outcomes. The biological activity of glucocorticoids depends on the unbound, free fraction. We aimed to evaluate plasma free cortisol (FC) concentrations in patients with ACS in this cross-sectional study. One hundred and ten AI patients in 3 groups; non-functioning (NFA, n=33), possible ACS (n=65), ACS (n=12) were enrolled. Following measurements were conducted: Clinical data and total serum cortisol (TC), plasma corticotrophin (ACTH), serum dehydroepiandrosterone sulfate (DHEA-S), cortisol after 1 mg dexamethasone by both immunoassay and LC-MS/MS (DexF), serum corticosteroid binding globulin (CBG), plasma dexamethasone concentration [DEX] and plasma FC by LC-MS/MS. Patients with ACS featured an unfavorable metabolic profile. Plasma [DEX] and serum CBG levels were similar between groups. Plasma FC was significantly higher in ACS when compared to NFA and possible ACS groups p<0.05 and p<0.01, respectively. In multiple regression analysis DexF (beta=0.402, p<0.001) and CBG (beta=−0.257, p=0.03) remained as the independent predictors of plasma FC while age, sex, BMI, smoking habit, and existing cardiovascular disease did not make a significant contribution to the regression model. In conclusion, the magnitude of cortisol excess in ACS could lead to increased plasma FC concentrations. Further studies in AI patients are needed to demonstrate whether any alterations of cortisol affinity for CBG exist and to establish whether plasma FC concentrations predict the unfavorable metabolic profile in ACS.
Genetic syncretism: Latin American forensics and global indigenous organizing
Authors: Smith Lindsay A. , García-Deister Vivette 
Published: November 2021

AbstractIn the 1970s, Latin America became a global laboratory for military interventions, the cultivation of terror, and ideological and economic transformation. In response, family groups and young scientists forged a new activist forensics focused on human rights, victim-centered justice, and state accountability, inaugurating new forms of forensic practice. We examine how this new form of forensic practice centered in forensic genetics has led to a critical engagement with Indigeneity both within and outside the lab. Drawing on ethnographic fieldwork with human rights activists and forensic scientists in Argentina, Guatemala and Mexico, this paper examines the relationship between forensic genetics, Indigenous organizing, and human rights practice. We offer the concept of ‘genetic syncretism’ to attend to spaces where multiple and competing beliefs about genetics, justice, and Indigenous identity are worked out through (1) coming together in care, (2) incorporation, and (3) ritual. Helping to unpack the uneasy and incomplete alliance of Indigenous interests and forensic genetic practice in Latin American, genetic syncretism offers a theoretical lens that is attentive to how differentials of power embedded in colonial logics and scientific practice are brokered through the coming together of seemingly incompatible beliefs and practices.
Deconvolution of multi-Boltzmann x-ray distribution from linear absorption spectrometer via analytical parameter reduction
Authors: Armstrong C. D. , Neely D. , Kumar D. , McKenna P. , Gray R. J. , Pirozhkov A. S. 
Published: November 2021

Accurate characterization of incident radiation is a fundamental challenge for diagnostic design. Herein, we present an efficient spectral analysis routine that is able to characterize multiple components within the spectral emission by analytically reducing the number of parameters. The technique is presented alongside the design of a hard x-ray linear absorption spectrometer using the example of multiple Boltzmann-like spectral distributions; however, it is generally applicable to all absorption based spectrometer designs and can be adapted to any incident spectral shape. This routine is demonstrated to be tolerable to experimental noise and suitable for real-time data processing at multi-Hz repetition rates.
Design and commissioning of a neutron counter adapted to high-intensity laser matter interactions
Authors: Lelasseux V. , Söderström P.-A. , Aogaki S. , Burdonov K. , Cerchez M. , Chen S. N. , Dorard S. , Fazzini A. , Gugiu M. , Pikuz S. , Rotaru F. , Willi O. , Negoita F. , Fuchs J. 
Published: November 2021

The advent of multi-PW laser facilities world-wide opens new opportunities for nuclear physics. With this perspective, we developed a neutron counter taking into account the specifics of a high-intensity laser environment. Using GEANT4 simulations and prototype testings, we report on the design of a modular neutron counter based on boron-10 enriched scintillators and a high-density polyethylene moderator. This detector has been calibrated using a plutonium–beryllium neutron source and commissioned during an actual neutron-producing laser experiment at the LULI2000 facility (France). An overall efficiency of 4.37(59)% has been demonstrated during calibration with a recovery time of a few hundred microseconds after laser–plasma interaction.
Research on sound power measurement of multi-element ultrasonic focusing transducer based on cross-spectrum method
Authors: Yu Longjing , Zheng Huifeng 
Published: November 2021

In this paper, aiming at the problem that a multi-array focused ultrasonic transducer working in a high power range has a nonlinear influence on the measurement accuracy, a study of acoustic power measurement based on the near field cross-spectrum method was carried out. The focused acoustic field of a multi-array transducer was derived theoretically by combining the cross-spectrum method and the Westervelt nonlinear acoustic propagation equation. Finite element simulation was used to establish the model of the focused sound field of the multi-array transducer under different excitation conditions, and the influence law of each harmonic on the total sound power under specific excitation conditions was obtained. A cross-spectrum measurement system was built to scan the two near focusing planes under different excitation conditions. The total energy, each harmonic energy, and their proportion in the focusing region under the corresponding excitation were obtained through calculation and processing. The theoretical and simulation results were verified, and the harmonic energies were compensated in the calculation of the total ultrasonic power. The measurement results were compared with those obtained by radiation force balances. It was found that the maximum measurement deviation of compensated ultrasonic power was 7.89%, which met the requirements of acoustic measurement. The accuracy of the method and conclusion was verified under the power range of 10–60 W.