bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Posttraumatic Stress Disorder and Sexual Difficulties: A Systematic Review of Veterans and Military Personnel
Authors: Bird Elizabeth R. , Piccirillo Marilyn , Garcia Natalia , Blais Rebecca , Campbell Sarah 
Published: July 2021

ABSTRACTBackgroundPosttraumatic stress disorder (PTSD) is associated with sexual difficulties but the nuances of this relationship remain elusive. Research has increased in recent years, most notably following publication of several reviews in 2015.AimThis systematic review examines the relationship between PTSD and sexual difficulties in veterans/military personnel.MethodsA systematic review was conducted using PRISMA guidelines in PsycINFO and PubMed databases for studies examining a diagnosis of PTSD or PTSD severity in relation to a range of sexual difficulties. Forty-three studies were identified that met inclusion and exclusion criteria for this review.RESULTSPTSD was associated with increased risk of experiencing at least one sexual difficulty. PTSD was most clearly associated with overall sexual function, sexual desire, sexual satisfaction, and sexual distress. Results were mixed for sexual arousal, orgasm function, erectile dysfunction, premature ejaculation, sexual pain, and frequency of sexual activity. PTSD symptom clusters of avoidance and negative alterations in cognition/mood were most commonly associated sexual difficulties. Few studies compared results by gender and trauma type.Clinical ImplicationsClinicians should inquire about sexual health in relation to PTSD symptoms and target avoidance and negative mood symptoms by incorporating sexual exposure assignments and sexual activation exercises when appropriate.Strengths & LimitationsThis systematic review synthesizes an extensive literature that has grown substantially in the past 5 years and includes studies with low to moderate risk of bias. Limitations of the existing literature include challenges differentiating between PTSD and depression, inconsistent measurement of PTSD and trauma histories, inconsistent operationalization and measurement of sexual outcomes, and largely cross-sectional study designs.CONCLUSIONPTSD is linked to a range of sexual outcomes. The current literature suggests that PTSD is associated with sexual difficulties related to both the sexual response cycle (ie, sexual desire) and one’s emotional relationship to sexual activity (eg, sexual distress). More research is needed to increase confidence in findings.
Disavowing Disability
Authors: McKendry Andrew 
Published: July 2021

Disavowing Disability examines the role that disability, both as a concept and an experience, played in seventeenth-century debates about salvation and religious practice. Exploring how the use and definition of the term 'disability' functioned to allocate agency and culpability, this study argues that the post-Restoration imperative to capacitate 'all men'—not just the 'elect'—entailed a conceptual circumscription of disability, one premised on a normative imputation of capability. The work of Richard Baxter, sometimes considered a harbinger of 'modernity' and one of the most influential divines of the Long Eighteenth Century, elucidates this multifarious process of enabling. In constructing an ideology of ability that imposed moral self-determination, Baxter encountered a germinal form of the 'problem' of disability in liberal theory. While a strategy of 'inclusionism' served to assimilate most manifestations of alterity, melancholy presented an intractability that frustrated the logic of rehabilitation in fatal ways. This title is also available as Open Access on Cambridge Core.
Importance of the Northward IMF for the Quasistatic Mesoscale Field‐Aligned Currents Embedded in the Diminished Region 1/2 Current System in the Dusk Sector
Authors: Yokoyama Y. , Taguchi S. , Iyemori T. 
Published: July 2021

AbstractTo understand the features of the quasistatic field‐aligned currents (FACs) consisting of multiple mesoscale (∼10–100 km) upward and downward FAC regions in the duskside auroral oval, we examined the magnetic field data obtained through the constellation measurements of Swarm satellites for a duration of more than three years. We introduced a method of automated event identification and took the events in 577 satellite orbits that pass through the high‐latitude part of the 14–18 magnetic local time auroral oval. The results of the analysis reveal that the occurrence ratio of the FAC events increases with the IMF BZ, and that the event can be detected at a ratio exceeding 20% for BZ greater than 1 nT. This indicates that the quasistatic mesoscale FACs in the duskside sector are pertinent to a northward IMF condition and that they are not a simple remnant of the diminished Region 1. The results also show that the FAC density tends to increase with the solar wind proton density, implying that the latter is directly associated with FAC generation. The FAC events can occur in a wide range of solar zenith angles, that is, 65–135°, indicating that whether the ionosphere is sunlit or dark is not crucial for the appearance of the event. These results strongly suggest that multiple mesoscale FACs are produced in the low‐latitude boundary layer through a mechanism related to solar wind plasma entry processes that can be more easily attained as the northward component of the IMF increases.
Detailed Structure of Very High‐β Earth Bow Shock
Authors: Petrukovich A. A. , Chugunova O. M. 
Published: July 2021

AbstractObservations of Earth's bow shock with high (ratio of thermal to magnetic pressure) are rare. However, such shocks are supposed to be ubiquitous in astrophysical plasmas. We present statistics of several tens crossings with for MMS, Cluster and Geotail, 30 of which have . For the latter subset, most of the crossings reveal upstream structure with the periodically emerging activations, gradually thermalizing the solar wind ion flow. One fortuitous MMS shock event allowed to study this phenomenon with unprecedented details. Each activation, in turn, consists of high‐amplitude magnetic variations with the period about 1 s, coupled with the pulses of the plasma flow. These variations have wavelengths of about 150 km, linear polarization and are almost standing in the plasma rest frame, consistent with the expectation for Weibel mode. All together, the transition interval may last 5–10 min, but corresponds to a proton cyclotron scale in the solar wind, due to very low magnetic field and very slow shock motion. The most likely physical cause of this extended upstream activity is reformation of a supercritical shock.
Machine Learning Predicts the Timing and Shear Stress Evolution of Lab Earthquakes Using Active Seismic Monitoring of Fault Zone Processes
Authors: Shreedharan Srisharan , Bolton David Chas , Rivière Jacques , Marone Chris 
Published: July 2021

AbstractMachine learning (ML) techniques have become increasingly important in seismology and earthquake science. Lab‐based studies have used acoustic emission data to predict time‐to‐failure and stress state, and in a few cases, the same approach has been used for field data. However, the underlying physical mechanisms that allow lab earthquake prediction and seismic forecasting remain poorly resolved. Here, we address this knowledge gap by coupling active‐source seismic data, which probe asperity‐scale processes, with ML methods. We show that elastic waves passing through the lab fault zone contain information that can predict the full spectrum of labquakes from slow slip instabilities to highly aperiodic events. The ML methods utilize systematic changes in P‐wave amplitude and velocity to accurately predict the timing and shear stress during labquakes. The ML predictions improve in accuracy closer to fault failure, demonstrating that the predictive power of the ultrasonic signals improves as the fault approaches failure. Our results demonstrate that the relationship between the ultrasonic parameters and fault slip rate, and in turn, the systematically evolving real area of contact and asperity stiffness allow the gradient boosting algorithm to “learn” about the state of the fault and its proximity to failure. Broadly, our results demonstrate the utility of physics‐informed ML in forecasting the imminence of fault slip at the laboratory scale, which may have important implications for earthquake mechanics in nature.
Quantifying Tectonic and Glacial Controls on Topography in the Patagonian Andes (46.5°S) From Integrated Thermochronometry and Thermo‐Kinematic Modeling
Authors: Andrić‐Tomašević Nevena , Falkowski Sarah , Georgieva Viktoria , Glotzbach Christoph , Strecker Manfred R. , Ehlers Todd A. 
Published: July 2021

AbstractThe Patagonian Andes have been used to illustrate the dependency of major topographic changes in response to glacial erosion processes dominating over tectonic deformation and uplift. Here, we investigate tectonic and glacial contributors to the erosion history and evolution of topography in the Patagonian Andes at 46.5°S. We present 33 new apatite and zircon (U‐Th)/He (AHe and ZHe, respectively) and fission track (AFT and ZFT, respectively) ages integrated with 46 previously published bedrock thermochronometric ages in a 3D thermo‐kinematic model. Observed thermochronometer ages increase from the eastern flank of the topographic crest of the orogen toward the eastern retro‐foreland basin (from AFT 4–10 Ma, ZHe 4–12 Ma, ZFT 6–14 Ma to AFT 28–32 Ma, ZHe 68–117 Ma). Thermo‐kinematic modeling indicates that spatial gradients in thermochronometric ages can be explained by an up to 100‐km‐wide, parabolic‐shaped pattern in exhumation rates with a maximum rate of 0.5 mm/yr from 15 Ma until the onset of glaciation at ∼7 Ma. Furthermore, model results suggest that the youngest AHe ages require a localized acceleration in erosion from ∼0.5 mm/yr to ∼2.2 mm/yr starting between ∼5 and ∼3 Ma, coeval with intensified glaciation and subduction of the Chile Rise. Our results suggest that the long‐wavelength (∼100 km) topography and erosion patterns are likely controlled by rock uplift above mid‐crustal ramp(s) and subsequent transpression along the Liquiñe‐Ofqui Fault. Superposed on these tectonic processes, Late Cenozoic glaciation resulted in localized and accelerated erosion over wavelengths of <20 km.
Temporal and Spatial Variations in Rock Uplift From River‐Profile Inversions at the Central Anatolian Plateau Southern Margin
Authors: Racano Simone , Schildgen Taylor F. , Cosentino Domenico , Miller Scott R. 
Published: July 2021

AbstractIn geodynamically active areas, spatio‐temporal variations in rock uplift can provide key insights into the processes responsible for the evolution of topography. The Central Anatolian Plateau (CAP) southern margin experienced a rapid rock‐uplift pulse with maximum rates of 3.5 m/kyr during the Quaternary, based on marine sediments dated to the middle Pleistocene that are now located at 1,500 m.a.s.l. Fluvial landscapes record elements that reflect temporal and spatial variations in rock‐uplift rates, such as the normalized river steepness index, which is affected by rock‐uplift rate, the erodibility of the underlying rock, and climate. Following the calibration of river profiles for an erosion coefficient value, which can be done using independent data (in our case, uplifted marine terraces and dated marine sediments), river profiles can be inverted for the rock‐uplift histories that created them. Here, we demonstrate how it is possible to define the spatio‐temporal rock‐uplift history of the CAP southern margin by quantitative analysis of river profiles.
Daytime Pc5 Diffuse Auroral Pulsations and Their Association With Outer Magnetospheric ULF Waves
Authors: Motoba T. , Ogawa Y. , Ebihara Y. , Kadokura A. , Gerrard A. J. , Weatherwax A. T. 
Published: July 2021

AbstractSouth Pole Station, Antarctica (SPA, magnetic latitude = −74.5°, magnetic local time (MLT) = UT–3.5 h), is a unique observatory which can capture daytime auroral forms throughout austral winter season. We have studied the properties and origin of ultralow‐frequency (ULF) range modulation of daytime diffuse aurora, using data acquired on June 23, 2017 by multi‐instrument measurements at SPA and in situ measurements in the dayside outer magnetosphere. At 1500–1600 UT, monochromatic Pc5‐range pulsations (period ∼10 min) emerged in the midday diffuse auroral region. The sequential 2‐D images reveal that the auroral pulsations result from the repetitive formation of faint, diffuse auroral patches, propagating poleward at a speed of ∼1.5 km s−1. Interestingly, no obviously similar magnetic pulsations were found at SPA. The results differ fundamentally from the ground optical and magnetic signatures expected for a standing field line resonance. On the other hand, the co‐located riometer and VLF receiver observed clearly synchronized pulsations, suggesting that tens‐of‐keV electrons interact with modulated chorus waves and then are scattered down to the auroral pulsation region. During the same interval, the THEMIS‐D spacecraft detected corresponding Pc5 oscillations in the dayside outer magnetosphere (9–10 RE and ∼15 MLT). The compressional component of the magnetospheric Pc5 waves, presumably driven by an external source, exhibited a good correspondence to the daytime Pc5 auroral pulsations. The simultaneous SPA–THEMIS observations highlight the role of compressional Pc5 pulsations in the dayside outer magnetosphere in determining the periodicity of daytime high‐latitude diffuse auroral pulsations.
Environmental Controls of InSAR‐Based Periglacial Ground Dynamics in a Sub‐Arctic Landscape
Authors: Rouyet L. , Karjalainen O. , Niittynen P. , Aalto J. , Luoto M. , Lauknes T. R. , Larsen Y. , Hjort J. 
Published: July 2021

AbstractPeriglacial environments are characterized by highly dynamic landscapes. Freezing and thawing lead to ground movement, associated with cryoturbation and solifluction. These processes are sensitive to climate change and variably distributed depending on multiple environmental factors. In this study, we used multi‐geometry Sentinel‐1 Synthetic Aperture Radar Interferometry (InSAR) to investigate the spatial distribution of the mean annual ground velocity in a mountainous landscape in Northern Norway. Statistical modeling was employed to examine how periglacial ground velocity is related to environmental variables characterizing the diverse climatic, geomorphic, hydrological and biological conditions within a 148 km2 study area. Two‐dimensional (2D) InSAR results document mean annual ground velocity up to 15 mm/yr. Vertical and horizontal velocity components in the East–West plane show variable spatial distribution, which can be explained by the characteristics of cryoturbation and solifluction operating differently over flat and sloping terrain. Statistical modeling shows that slope angle and mean annual air temperature variables are the most important environmental factors explaining the distribution of the horizontal and vertical components, respectively. Vegetation and snow cover also have a local influence, interpreted as indicators of the ground material and moisture conditions. The results show contrasted model performance depending on the velocity component used as a response variable. In general, our study highlights the potential of integrating radar remote sensing and statistical modeling to investigate mountainous regions and better understand the relations between environmental factors, periglacial processes and ground dynamics.
Spectral Fidelity of Earth's Terrestrial and Aquatic Ecosystems
Authors: Thompson David R. , Brodrick Philip G. , Cawse‐Nicholson Kerry , Dana Chadwick K. , Green Robert O. , Poulter Benjamin , Serbin Shawn , Shiklomanov Alexey N. , Townsend Philip A. , Turpie Kevin R. 
Published: July 2021

AbstractThe Surface Biology and Geology (SBG) investigation will create global maps of spectral surface reflectance and emissivity at a cadence of 16 days or better, with coverage to address global questions about Earth's geology, cryosphere and ecosystems. The revolutionary potential poses a commensurate challenge: creating contiguous maps free from regional biases induced by atmosphere, observation geometry, or inversion error. This will require an accurate calibration with precise knowledge of each channel's spectral response. Here, we quantify the impact of spectral calibration on SBG's aquatic and terrestrial ecosystem objectives. We find that contemporary algorithms for ecosystem trait retrieval demand more accurate spectral calibration than historical missions. Errors due to drift or spatial nonuniformity in the wavelength calibration that have previously been considered acceptable can cause systematic errors larger than the instrument noise and of the same order as the variability SBG aims to measure. Moreover, their impact on atmospheric correction can induce climate‐dependent systematic errors that thwart comparisons between ecosystems. These results underscore the importance of spectral response accuracy in SBG mission design.
The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis
Authors: Kobelt Dennis , Perez-Hernandez Daniel , Fleuter Claudia , Dahlmann Mathias , Zincke Fabian , Smith Janice , Migotti Rebekka , Popp Oliver , Burock Susen , Walther Wolfgang , Dittmar Gunnar , Mertins Philipp , Stein Ulrike 
Published: July 2021

AbstractCancer metastasis causes >90% of cancer deaths and remains a major treatment challenge. Here we deciphered the impact of tyrosine phosphorylation of MACC1, a causative driver for cancer metastasis, for cancer cell signaling and novel interventions to restrict cancer metastasis. We identified MACC1 as new MEK1 substrate. MEK1 directly phosphorylates MACC1, leading to accelerated and increased ERK1 activation. Mutating in silico predicted hierarchical MACC1 tyrosine phosphorylation sites abrogates MACC1-induced migration, invasion, and MET expression, a transcriptional MACC1 target. Targeting MEK1 by RNAi or clinically applicable MEK1 inhibitors AZD6244 and GSK1120212 reduces MACC1 tyrosine phosphorylation and restricts MACC1-induced metastasis formation in mice. Although MEK1 levels, contrary to MACC1, are not of prognostic relevance for CRC patients, MEK1 expression was found indispensable for MACC1-induced metastasis. This study identifies MACC1 as new MEK1 substrate for tyrosine phosphorylation decisively impacting cell motility, tumor growth, and metastasis. Thus, MAP kinase signaling is not linear leading to ERK activation, but branches at the level of MEK1. This fundamental finding opens new therapeutic options for targeting the MEK1/MACC1 axis as novel vulnerability in patients at high risk for metastasis. This might be extended from CRC to further solid tumor entities.
Importance of test–retest reliability for promoting fMRI based screening and interventions in major depressive disorder
Authors: Compère Laurie , Siegle Greg J. , Young Kymberly 
Published: July 2021

AbstractProponents of personalized medicine have promoted neuroimaging in three areas of clinical application for major depression: clinical prediction, outcome evaluation, and treatment, via neurofeedback. Whereas psychometric considerations such as test–retest reliability are basic precursors to clinical adoption for most clinical instruments, we show, in this article, that basic psychometrics have not been regularly attended to in fMRI of depression. For instance, no fMRI neurofeedback study has included measures of test–retest reliability, despite the implicit assumption that brain signals are stable enough to train. We consider several factors that could be useful to aid clinical translation, including (1) attending to how the BOLD response is parameterized, (2) identifying and promoting regions or voxels with stronger psychometric properties, (3) accounting for within-individual changes (e.g., in symptomatology) across time, and (4) focusing on tasks and clinical populations that are relevant for the intended clinical application. We apply these principles to published prognostic and neurofeedback data sets. The broad implication of this work is that attention to psychometrics is important for clinical adoption of mechanistic assessment, is feasible, and may improve the underlying science.
Title: “Labels Matter: Is it stress or is it Trauma?”
Authors: Richter-Levin Gal , Sandi Carmen 
Published: July 2021

AbstractIn neuroscience, the term ‘Stress’ has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the rule and stress-related pathology the exception. This is critical because neural mechanisms associated with stress-related psychopathology are expected to differ significantly from those associated with resilience.Research labels and terminology affect research directions, conclusions drawn from the results, and the way we think about a topic, while choice of labels is often influenced by biases and hidden assumptions. It is therefore important to adopt a terminology that differentiates between stress conditions, leading to different outcomes.Here, we propose to conceptually associate the term ‘stress’/‘stressful experience’ with ‘stress resilience’, while restricting the use of the term ‘trauma’ only in reference to exposures that lead to pathology. We acknowledge that there are as yet no ideal ways for addressing the murkiness of the border between stressful and traumatic experiences. Yet ignoring these differences hampers our ability to elucidate the mechanisms of trauma-related pathologies on the one hand, and of stress resilience on the other. Accordingly, we discuss how to translate such conceptual terminology into research practice.
Oxygen-doped hollow, porous NiCoP nanocages derived from Ni–Co prussian blue analogs for oxygen evolution
Authors: Li Di , Zhou Changjian , Xing Yingying , Shi Xiangli , Ma Wanxia , Li Longhua , Jiang Deli , Shi Weidong 
Published: July 2021

An oxygen-doped, hollow, porous NiCoP nanocages electrocatalyst was synthesized via phosphorization and air-annealing treatment of Ni–Co Prussian blue analogs. This unique nanocage exhibited an overpotential of 310 mV at 10 mA cm−2 in the oxygen-evolution reaction.
Biological implications of genetic variations in autism spectrum disorders from genomics studies
Authors: Zhang Yue , Liu Xuanshi , Guo Ruolan , Xu Wenjian , Guo Qi , Hao Chanjuan , Ni Xin , Li Wei 
Published: July 2021

Abstract
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental condition characterized by atypical social interaction and communication together with repetitive behaviors and restricted interests. The prevalence of ASD has been increased these years. Compelling evidence has shown that genetic factors contribute largely to the development of ASD. However, knowledge about its genetic etiology and pathogenesis is limited. Broad applications of genomics studies have revealed the importance of gene mutations at protein-coding regions as well as the interrupted non-coding regions in the development of ASD. In this review, we summarize the current evidence for the known molecular genetic basis and possible pathological mechanisms as well as the risk genes and loci of ASD. Functional studies for the underlying mechanisms are also implicated. The understanding of the genetics and genomics of ASD is important for the genetic diagnosis and intervention for this condition.