bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing knowledge on skin ulcer healing: a living scoping review protocol
Authors: Gomes João , Sousa Paulino , Pereira Filipe , Queirós Carmen , Neves Hugo , Silva Catarina , Silva Abel Paiva e , Parente Paulo , Sousa Paula , Brito Alice , Silva Antónia Paiva e , Morais Ernesto Jorge , Cardoso Alexandrina , Cruz Inês , Machado Natália , Oliveira Fernando , Bastos Fernanda , Prata Paula , Sequeira Carlos 
Published: June 2021

ABSTRACT

Objective:
This review aims to continuously map the nursing knowledge on skin ulcer healing in any context of care.

Introduction:
Chronic wounds are an increasing concern for society and health care providers. Pressure ulcers and venous ulcers, among others, have devastating effects on morbidity and quality of life and require a systematic approach. The nursing process is an important method that allows a better organization and overall care quality for a systematic and continuous professional approach to nursing management of skin ulcers. The integration of this nursing knowledge in informatics systems creates an opportunity to embed decision-support models in clinical activity, promoting evidence-based practice.

Inclusion criteria:
This scoping review will consider articles on nursing data, diagnosis, interventions, and outcomes focused on people with skin ulcers in all contexts of care. This review will include quantitative, qualitative, and mixed methods study designs as well as systematic reviews and dissertations.

Methods:
JBI's scoping review guidance, as well as the Cochrane Collaboration's guidance on living reviews, will be followed to meet the review's objective. Screening of new literature will be performed regularly, with the review updated according to new findings. The search strategy will map published and unpublished studies. The databases to be searched include MEDLINE, CINAHL, Scopus, JBI Evidence Synthesis, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and PEDro. Searches for unpublished studies will include OpenGrey and Repositórios Científicos de Acesso Aberto de Portugal. Studies published in English and Portuguese since 2010 will be considered for inclusion.

Scoping Review Protocol Registration:
Open Science Framework: https://osf.io/f6s4e/
High-harmonic spectra of hexagonal nanoribbons from real-space time-dependent Schrödinger calculations
Authors: Drüeke Helena , Bauer Dieter 
Published: June 2021

AbstractHigh-harmonic spectroscopy is a promising candidate for imaging electronic structures and dynamics in condensed matter by all-optical means and with unprecedented temporal resolution. We investigate harmonic spectra from finite, hexagonal nanoribbons, such as graphene and hexagonal boron nitride, in armchair and zig-zag configuration. The symmetry of the system explains the existence and intensity of the emitted harmonics.
Multiparametric Photoacoustic Analysis of Human Thyroid Cancers In Vivo
Authors: Kim Jeesu , Park Byullee , Ha Jeonghoon , Steinberg Idan , Hooper Sarah M. , Jeong Chaiho , Park Eun-Yeong , Choi Wonseok , Liang Tie , Bae Ja Seong , Managuli Ravi , Kim Yongmin , Gambhir Sanjiv S. , Lim Dong-Jun , Kim Chulhong 
Published: June 2021

Abstract

Thyroid cancer is one of the most common cancers, with a global increase in incidence rate for both genders. Ultrasound-guided fine-needle aspiration is the current gold standard to diagnose thyroid cancers, but the results are inaccurate, leading to repeated biopsies and unnecessary surgeries. To reduce the number of unnecessary biopsies, we explored the use of multiparametric photoacoustic (PA) analysis in combination with the American Thyroid Association (ATA) Guideline (ATAP). In this study, we performed in vivo multispectral PA imaging on thyroid nodules from 52 patients, comprising 23 papillary thyroid cancer (PTC) and 29 benign cases. From the multispectral PA data, we calculated hemoglobin oxygen saturation level in the nodule area, then classified the PTC and benign nodules with multiparametric analysis. Statistical analyses showed that this multiparametric analysis of multispectral PA responses could classify PTC nodules. Combining the photoacoustically indicated probability of PTC and the ATAP led to a new scoring method that achieved a sensitivity of 83% and a specificity of 93%. This study is the first multiparametric analysis of multispectral PA data of thyroid nodules with statistical significance. As a proof of concept, the results show that the proposed new ATAP scoring can help physicians examine thyroid nodules for fine-needle aspiration biopsy, thus reducing unnecessary biopsies.

Significance:
This report highlights a novel photoacoustic scoring method for risk stratification of thyroid nodules, where malignancy of the nodules can be diagnosed with 83% sensitivity and 93% specificity.
РОЗВИТОК КІНЕЗІТЕРАПІЇ У ФРАНЦІЇ (1970–2020)
Authors: Данилевич М. В. , Романчук О. В. , Коваль Р. С. , Федчишин Н. О. 
Published: June 2021

У статті проаналізовано розвиток кінезітерапії у Франції з 1970 до 2020 р. Наукову новизну роботи пояснюємо фактором того, що до сьогодні історія кінезітерапії у Франції не привертала уваги українських науковців, навіть не зважаючи на той факт, що якість надання медичних та реабілітаційних послуг у системі охорони здоровʼя цієї держави вважають однією з найвищих у світі.
У результаті проведеного аналізу виявлено, що у 80-х та 90-х роках ХХ століття відбувалося вдосконалення системи підготовки фахівців з кінезітерапії. У цей час було уточнено понятійно-категоріальний апарат, запропоновано визначення професійних дій, технік, методик; окреслено повноваження й обовʼязки кінезітерапевтів; запроваджено диплом працівника медичної сфери, спільний для багатьох парамедичних професій.
Зазначено, що у 2002 р. спеціальною постановою пацієнтам був наданий доступ до їхньої історії хвороби. У 2006 р. регламентовано перелік медичних засобів, які масажисти-кінезітерапевти можуть використовувати, засновано Національне обʼєднання масажистів-кінезітерапевтів. У 2008 р. був прийнятий, а у 2020 р. доповнений Кодекс деонтології у кінезітерапії.
Реформа системи підготовки масажистів-кінезітерапевтів розпочинається з 2015 р. зміною тривалості навчання з трьох на чотири роки, не враховуючи однорічний курс, спільний для всіх, хто навчається на медичних спеціальностях, а оцінка частини модулів здійснюється в університетах.
Інститути, які провадять підготовку фахівців галузі, сьогодні вводять доказову практику, що має на меті набуття необхідних компетенцій для пошуку теоретичної та клінічної інформації, її оцінювання щодо доцільності подальшого використання у професійній діяльності. У галузі починають активно застосовуватися цифрові технології. Політика у сфері охорони здоровʼя і новітні технології зумовили обовʼязкове ведення професійної документації, зокрема інформаційної картки пацієнта, яка вважається параметром якості та безпеки, і дозволяє повністю відслідковувати всі надані пацієнту медичні послуги.
На сьогодні у Франції функціонує ціла низка організацій, робота яких стосується професійної діяльності масажистів-кінезі­терапевтів. У 2016 р. запропоновано нове визначення галузі, однак тривають дискусії стосовно найменування самої сфери, ролі масажиста-кінезітерапевта, його співпраці з іншими фахівцями.
Abstract 196: Impact of Cholesteryl Ester Transfer Protein Inhibition With TA-8995 on High Density Lipoprotein Function
Authors: Shrestha Sudichhya , Jessup Wendy , Tabet Fatiha , Barter Philip J , Rye Kerry-Anne 
Published: June 2021

Background:
The effect of inhibiting cholesteryl ester transfer protein (CETP) activity on high density lipoprotein (HDL) function is poorly understood.

Aim:
To determine whether the CETP inhibitor, TA-8995, influences the cholesterol efflux capacity and anti-inflammatory properties of HDLs.

Methods:
Subjects were treated with TA-8995 (2.5 mg/day, n=14 or 10 mg/day, n=13), or placebo (n=14) for 12 weeks. Blood was collected prior to (Visit 2), and after TA-8995 treatment (Visit 5). The composition and size of ultracentrifugally isolated HDLs was determined. Serum cholesterol efflux was quantified in J774 macrophages and CHO cells. Inhibition of vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 expression was determined by flow cytometry in tumor necrosis factor (TNF)-alpha activated human coronary artery endothelial cells (HCAECs) after pre-incubation with isolated HDLs.

Results:
Plasma HDL-cholesterol (HDL-C) levels, HDL composition and size were comparable at Visit 2 and Visit 5 in the placebo group. Treatment with 2.5 and 10 mg TA-8995 increased HDL-C levels by 113±0.6% and 153±0.5%, respectively. HDL composition in the placebo and treatment groups was comparable at Visit 2. At Visit 5 the apoA-I/apoA-II molar ratio, and wt% phospholipid, cholesteryl ester and unesterified cholesterol increased and the wt% triglyceride and total protein decreased in both treatment groups. TA-8995 treatment also increased HDL size.

At Visit 5 versus Visit 2 cAMP-specific cholesterol efflux from J774 macrophages increased by 24±0.3% and 21±0.3%, respectively, in the 2.5 mg and 10 mg TA-8995 treatment groups while ABCA1-specific cholesterol efflux increased by 10±0.1% and 20±0.1%, respectively, and ABCG1-specific cholesterol efflux increased by 20±0.2% and 7±0.2%, respectively. Cholesterol efflux was comparable at Visit 2 and Visit 5 in the placebo group.
Pre-incubation of HCAECs with HDLs from the placebo and both TA-8995 treatment groups inhibited TNF-alpha-induced ICAM-1 and VCAM-1 expression comparably at Visits 2 and 5.

Conclusion:
Inhibition of CETP with TA-8995 changes HDL composition. It also increases HDL size and cholesterol efflux and conserves the anti-inflammatory properties of HDLs.
Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E–Deficient Mice
Authors: Huang Kan , Liu Chenshu , Peng Meixiu , Su Qiao , Liu Ruiming , Guo Zeling , Chen Sifan , Li Zilun , Chang Guangqi 
Published: June 2021

Background
Although glycoursodeoxycholic acid (GUDCA) has been associated with the improvement of metabolic disorders, its effect on atherosclerosis remains elusive. This study aimed to investigate the role of GUDCA in the development of atherosclerosis and its potential mechanisms.

Methods and Results

Human THP‐1 macrophages were used to investigate the effect of GUDCA on oxidized low‐density lipoprotein–induced foam cell formation in vitro. We found that GUDCA downregulated scavenger receptor A1 mRNA expression, reduced oxidized low‐density lipoprotein uptake, and inhibited macrophage foam cell formation. In an in vivo study, apolipoprotein E–deficient mice were fed a Western diet for 10 weeks to induce atherosclerosis, and then were gavaged once daily with or without GUDCA for 18 weeks. Parameters of systemic metabolism and atherosclerosis were detected. We found that GUDCA improved cholesterol homeostasis and protected against atherosclerosis progression as evidenced by reduced plaque area along with lipid deposition, ameliorated local chronic inflammation, and elevated plaque stability. In addition, 16S rDNA sequencing showed that GUDCA administration partially normalized the Western diet–associated gut microbiota dysbiosis. Interestingly, the changes of bacterial genera (
Alloprevotella
,
Parabacteroides
,
Turicibacter
, and
Alistipes
) modulated by GUDCA were correlated with the plaque area in mice aortas.

Conclusions
Our study for the first time indicates that GUDCA attenuates the development of atherosclerosis, probably attributable to the inhibition of foam cell formation, maintenance of cholesterol homeostasis, and modulation of gut microbiota.
Charisma and History
Authors: Rotberg Robert I. 
Published: June 2021

Abstract
Because charisma is a social phenomenon, not an individual trait, its analytical utility in assessing and evaluating the quality and character of political leadership remains questionable. Cultural differences influence the traits and attributes that are internalized by one set of followers and not others. At the nation-state level, political leaders do arise who mesmerize their constituents charismatically, but too frequently that appeal is episodic, transient, and easily forfeited. Most of all, successful political leadership is more than behaving charismatically; delivering results in the form of economic growth, educational advances, health and medical services, and national self-respect are more important and more lasting. David Bell brings all of those considerations to the fore in a remarkable book that analyzes the charismatic appeals of Washington, Napoleon, Louverture, Paoli, and Bolivar, and raises important questions about the force of charisma in history.
Women and the Egyptian Muslim Brotherhood post-2013: Calls for Gender Reforms and Pluralism
Authors: Biagini Erika 
Published: June 2021

Abstract
The Muslim Brotherhood’s brief period of governance in Egypt, followed by its 2013 ousting from, power heightened the movement’s pre-existing internal divisions, causing members to question the tenets upon which the organization was established and ran. Since then, a growing body of literature has investigated the Brotherhood members’ call for internal reforms, but this rests largely on the views of its male members. In order to fill this gap, this article explores how the Muslim Sisterhood, an important but often overlooked Brotherhood constituency, envisages the movement changing in the aftermath of 2013. Findings based on interviews with Muslim Sisterhood members suggest that the central issues over which women envisage change within the movement include the Sisterhood’s desire for greater pluralism, the possibility to express women’s diverse identities, and the ability to pursue personal ambitions.
The Psychological Impact of COVID-19 on Individuals With and Without Mental Health Disorders
Authors: Campos Juliana Alvares Duarte Bonini , Campos Lucas Arrais , Martins Bianca Gonzalez , Valadão Dias Filomena , Ruano Rodrigo , Maroco João 
Published: June 2021

Objective To identify people with history of mental health disorders before the COVID-19 pandemic in the Brazilian population and estimate the prevalence of mood swings and the subjective distress of the pandemic among individuals with or without mental health disorders. Methods Through an online survey, participants were asked about presence or absence of mental health disorders. In addition, they answered the Brunel Mood Scale and the Impact of Event Scale. The mean percentile of mood swing indicators and psychological impact scores were estimated, and data were analyzed by logistic regression. Results 13,248 people participated (70.5% women, mean age 35.4 years, 31.2% with history of mental health disorder). Women and younger people were more likely to be diagnosed with mental health disorder. All participants had significant changes in mood due to the pandemic. Anger, depressed mood, mental confusion, and fatigue were higher among individuals with bipolar disorder or with combined disorders. Individuals with mental health disorders had a greater subjective distress, especially the group with bipolar disorder (OR = 4.89 [3.64–6.56]) and combined disorders (OR = 6.89 [5.21–9.10]). Conclusion Individuals previously diagnosed with mental health disorders at some point in life are more vulnerable to psychological impact from the pandemic.
Outcomes of Barotrauma in Critically Ill COVID-19 Patients With Severe Pneumonia
Authors: Gazivoda Victor P. , Ibrahim Mudathir , Kangas-Dick Aaron , Sun Arony , Silver Michael , Wiesel Ory 
Published: June 2021

Background: Pneumomediastinum and pneumothorax are complications which may be associated with barotrauma in mechanically ventilated patients. The current literature demonstrates unclear outcomes regarding barotrauma in critically ill patients with severe COVID-19. The purpose of this study was to examine the incidence of barotrauma in patients with severe COVID-19 pneumonia and its influence on survival. Study Design and Methods: A retrospective cohort study was performed from March 18, 2020 to May 5, 2020, with follow-up through June 18, 2020, encompassing critically ill intubated patients admitted for COVID-19 pneumonia at an academic tertiary care hospital in Brooklyn, New York. Critically ill patients with pneumomediastinum, pneumothorax, or both (n = 75) were compared to those without evidence of barotrauma (n = 206). Clinical characteristics and short-term patient outcomes were analyzed. Results: Barotrauma occurred in 75/281 (26.7%) of included patients. On multivariable analysis, factors associated with increased 30-day mortality were elevated age (HR 1.015 [95% CI 1.004-1.027], P = 0.006), barotrauma (1.417 [1.040-1.931], P = 0.027), and renal dysfunction (1.602 [1.055-2.432], P = 0.027). Protective factors were administration of remdesivir (0.479 [0.321-0.714], P < 0.001) and receipt of steroids (0.488 [0.370-0.643], P < 0.001). Conclusion: Barotrauma occurred at high rates in intubated critically ill patients with COVID-19 pneumonia and was found to be an independent risk factor for 30-day mortality.
A Multicomponent Home-Based Intervention for Neuropsychiatric Symptoms in People With Dementia and Caregivers’ Burden and Depression: A 6-Month Longitudinal Study
Authors: Mougias Antonis A. , Christidi Foteini , Kontaxopoulou Dionysia , Zervou Mariyanna , Kostoglou Dimitra , Vlami Maria Anna , Dimitriou Maria , Politis Antonis 
Published: June 2021

Objectives: Many people with dementia live in their home and require ongoing care, which is often provided by informal family caregivers. Thus, we examined the effectiveness of a multicomponent home-based intervention by evaluating its impact on a) neuropsychiatric symptoms of people with dementia and b) burden and depression of their caregivers. Methods: During the first 6 months of this prospective single-center study, we applied a home-based multicomponent intervention in 205 dyads of care-recipients and caregivers. In further analyzes, we included only dyads of caregivers and care-recipients with available data both at baseline and 6-month follow-up (N = 144). All assessments were conducted at home and included sociodemographic features, care-recipients’ clinical data, cognitive status (Mini-Mental State Examination), activities of daily living (Instrumental Activities of Daily Living; Katz Index of Independence in Activities of Daily Living), neuropsychiatric symptoms (Neuropsychiatric Inventory), and caregivers’ burden (Zarit Burden Inventory) and depression (Center for Epidemiological Studies-Depression). Results: We found significant decreases in the severity (pFDR = 0.002) and associated distress (pFDR = 0.001) of neuropsychiatric symptoms, as well as caregivers’ burden (pFDR = 0.004) and depressive symptoms (pFDR = 0.001). As expected, there was significant deterioration in care-recipients’ cognitive status (pFDR = 0.005) and measures of activities of daily living (pFDR < 0.005). Conclusion: Despite the progressive course of dementia, the home-based multicomponent intervention was effective in decreasing caregivers’ burden and depression and minimizing care-recipients’ neuropsychiatric symptoms’ severity and associated distress after 6 months. Our study highlights the establishment of home-based care units as an advantageous solution, specifically for family members seen to have a “taken-for-granted” role in dementia caring.
Neuro-psychiatric manifestations in patients with systemic lupus erythematosus: A systematic review and results from the Swiss lupus cohort study
Authors: Meier Aline L , Bodmer Nicolas S , Wirth Carla , Bachmann Lucas M , Ribi Camillo , Pröbstel Anne-Katrin , Waeber David , Jelcic Ilijas , Steiner Urs C ,   for the Swiss SLE Cohort Study (SSCS)
Published: June 2021

Objectives Systemic lupus erythematosus (SLE) is a systemic autoimmune disease associated with neuro-psychiatric (NP) manifestations. Frequency and patterns of neuro-psychiatric systemic lupus erythematosus (NPSLE) vary substantially between patients. We conducted a systematic review (SR) of the literature and examined prevalence and characteristics of NPSLE in the Swiss SLE cohort study (SSCS). Methods The SR search was performed between January 1999 and January 2020. We included prospective/cross-sectional studies focusing on NPSLE. We secured study characteristics, cohort compositions and frequencies of NP manifestations, assessed heterogeneity across reports and investigated sources of variation using meta-regression models. Regarding the SSCS, we reviewed all patients included and classified NP manifestations. Results The SR searches identified 530 studies. We included 22 studies in our meta-analysis, the mean frequency of NPSLE ranged from 10.6% to 96.4%. The frequency of NPSLE in the SSCS was 28.1%. Severe events including cerebrovascular insults, seizures and psychosis appeared in 7.1%, 5.3% and 6.5% respectively. There was a linear relationship between duration of SLE and cumulative incidence of NPSLE. Conclusions The spectrum of NPSLE is very broad. The diagnostic work-up and rates of reported manifestations varied substantially across studies. We call for concerted efforts and consensus regarding definitions of NPSLE that will facilitate accurate diagnosis and attribution to SLE, particularly with a view to timely intervention and patient outcomes.
A Meta-Analysis of Group Interventions for Trauma and Depression Among Immigrant and Refugee Children
Authors: Rafieifar Maryam , Macgowan Mark J. 
Published: June 2021

Purpose: A meta-analysis of group interventions to reduce post-traumatic stress symptoms (PTSS) and/or depression among refugee and immigrant children and adolescents. Methods: A systematic search was followed by independent reviews of each study for risk of bias. The meta-analysis pooled between- and within-condition effect sizes on PTSS and depression across studies using a random effects model. Results: The search yielded 16 studies utilizing eight interventions involving 976 participants. For all studies, within conditions, there were good effects on PTSS ( d = −0.66, 95% CI [−0.86, −0.46]) and depression ( d = −0.51, 95% CI [−0.79, −0.23]) with substantial heterogeneity. For studies with control groups, the between-group effect sizes yielded a small effect on PTSS ( d = −0.31, 95% CI [−0.65, 0.03]) with no significant effect on depression. Conclusions: The interventions helped to reduce PTSS and depression. Most studies lacked rigorous designs and provided little information on group variables needed for replication.