bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial
Authors: Yaskolka Meir Anat , Keller Maria , Bernhart Stephan H. , Rinott Ehud , Tsaban Gal , Zelicha Hila , Kaplan Alon , Schwarzfuchs Dan , Shelef Ilan , Gepner Yftach , Li Jun , Lin Yifei , Blüher Matthias , Ceglarek Uta , Stumvoll Michael , Stadler Peter F. , Stampfer Meir J. , Kovacs Peter , Liang Liming , Shai Iris 
Published: March 2021

AbstractBackgroundDNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple factors, including fat deposition, cardiometabolic risk factors and lifestyle weight-loss intervention, on the deviation of mAge from chronological age (mAge deviation) or 18-month change in mAge (∆mAge). In this sub-study of the CENTRAL magnetic resonance imaging weight-loss trial, we evaluated mAge by a validated 240-CpG-based prediction formula at baseline and after 18-month intervention of either low fat (LF) or mediterranean/low carbohydrate (MED/LC) diets.ResultsAmong 120 CENTRAL participants with abdominal obesity or dyslipidemia, mAge (mean ± SD: 60.3 ± 7.5 years) was higher than the chronological age (48.6 ± 9.3 years) but strongly correlated (r = 0.93;p = 3.1 × 10–53). Participants in the lowest tertile of mAge deviation from their chronological age had significantly lower waist-circumference, visceral adipose tissue, intrahepatic fat (IHF) content, fasting-glucose and HOMA-IR, as compared with participants in the highest sex-specific residual tertile (p < 0.05 for all). IHF% remained associated with greater mAge deviation after further adjustments (β = 0.23;p = 0.02). After 18-month weight-loss lifestyle intervention, mAge remained significantly correlated with chronological age (r = 0.94,p = 1.5 × 10–55). mAging occurred, with no difference between lifestyle intervention groups (∆ = 0.9 ± 1.9 years in MED/LC vs. ∆ = 1.3 ± 1.9 years in LF;p = 0.2); however, we observed a mAging attenuation in successful weight losers (> 5% weight loss) vs. weight-loss failures ( ∆ = 0.6 years vs. ∆ = 1.1 years;p = 0.04), and in participants who completed the trial with healthy liver fat content (< 5% IHF) vs. participants with fatty liver (∆ = 0.6 years vs. ∆ = 1.8 years;p = 0.003). Overall, 18 months of weight-loss lifestyle intervention attenuated the mAging of the men, mainly the older, by 7.1 months than the expected (p < 0.05).ConclusionsLifestyle weight-loss intervention may attenuate mAging. Deviation of mAge from chronological age might be related to body fat distribution and glycemic control and could indicate biological age, health status and the risk for premature cardiometabolic diseases.Trial registration: ClinicalTrials.gov NCT01530724. Registered 10 February 2012,https://clinicaltrials.gov/ct2/show/study/NCT01530724.
Existence results for infinite systems of the Hilfer fractional boundary value problems in Banach sequence spaces
Authors: Gholami Yousef 
Published: March 2021

AbstractThe main aim of this paper is to present some existence criteria for an infinite system of Hilfer fractional boundary value problems of the form$$ \mathcal{D}_{a^{+}}^{\alpha,\beta }u_{i}=-F_{i}(t,u),\quad u_{i}(a)=u_{i}(b)=0, a< t< b,i=1,2,\ldots, $$Da+α,βui=−Fi(t,u),ui(a)=ui(b)=0,a<t<b,i=1,2,…,in Banach sequence spaces of$c_{0}$c0and$l_{p},p\geq 1$lp,p≥1types. Our approach is based on the Darbo-type fixed point theorems acting on the condensing operators. The obtained existence results in each of the above sequence spaces are illustrated by presenting some numerical examples.
Sharing and connecting with others – patient experiences of radically open dialectical behavior therapy for anorexia nervosa and overcontrol: a qualitative study
Authors: Isaksson Martina , Ghaderi Ata , Wolf-Arehult Martina , Öster Caisa , Ramklint Mia 
Published: March 2021

AbstractBackgroundRecovery rates after psychological treatments for anorexia nervosa are low to moderate, and in adults, no treatment outperforms any other. The aim of this study was to evaluate patient experiences of Radically open dialectical behavior therapy (RO DBT), a treatment developed for disorders related to maladaptive overcontrol.MethodsEleven female patients with anorexia nervosa were interviewed after either treatment completion (eight patients) or drop-out (three patients) from RO DBT. Interviews were transcribed and analyzed with inductive thematic analysis.ResultsThe analysis yielded five main themes: 1) a comprehensive treatment, 2) the benefits of sharing and connecting with others, 3) growing trust, 4) moving toward valued goals – but some remain, and 5) doing well in treatment.ConclusionPatients appreciated what they described as a comprehensive treatment and holistic view of their problems, which helped them reduce both maladaptive overcontrol and eating disorder symptoms. Gradually sharing personal experiences both in- and outside therapy was described as essential and led to enhanced social connectedness.Trial registrationThe intervention study (Isaksson M, et al. J Behav Ther Exp Psychiatry. 71, 2021) that preceded this interview study was performed by the first, second, third, and fifth author, preregistered in the ISRCTN registry (no:ISRCTN47156042).
Geographical accessibility of medicines: a systematic literature review of pharmacy mapping
Authors: Tharumia Jagadeesan Cindrel , Wirtz Veronika J. 
Published: March 2021

Abstract
Background
Measuring access to medicines has often been limited to assessing availability and affordability, while little is known regarding other dimensions of access including geographical accessibility. Our study aims to provide a systematic review of literature on the accessibility of medicines by studying the geographical distribution of pharmacies using Spatial Analytical methods.

Methods
As systematic review of scientific peer-reviewed literature between 2000 and 2018 was carried out using PubMed, Web of Science, Google Scholar, Google and the Preferred Reporting items for Systematic Reviews and Meta-Analyses (PRISMA). Data regarding pharmacy density, distance to pharmacies in relation of pharmacy to sociodemographic factors and pharmacy characteristics were extracted from studies that meet the inclusion criteria.

Findings
Twenty papers fulfilled our inclusion criteria, of which only three were from middle income countries and rest from high-income economies. Pharmacy density per population was reported in 15 studies. Although geographical information was utilized in all studies, only 14 studies reported distance to pharmacies represented as Euclidean (straight line) distance. Disparities in accessibility was reported according to population income and rural or urban location. Seven studies described additional pharmacy characteristics including opening hours, presence of a pharmacist and delivery services.

Conclusions
Geographical accessibility is a key dimension of access to medicines. Pharmacy density per population is a relevant indicator to assess geographical accessibility which should be complemented by an equity analysis using socio-demographic information and population perception of accessibility.
Conversion surgery for metastatic gastric cancer at 2 years after initial diagnosis of cancer of unknown primary with metastasis of cervical lymph nodes and ovary: a case report
Authors: Suzuki Masaki , Hosaka Hisashi , Fukai Yasuyuki , Mochida Yasushi , Ozawa Daigo , Kogure Norimichi , Yamada Kazunosuke , Ojima Hitoshi 
Published: March 2021

Abstract
Background
Patients with stage IV gastric cancer have a poor prognosis despite improvements in intensive treatment regimens, including chemotherapy. Recently, conversion surgery has received much attention as it can provide long-term survival in stage IV gastric cancer patients who are responsive to chemotherapy. Herein, we describe the case of a patient who underwent conversion surgery for metastatic gastric cancer that was performed over 2 years after an initial diagnosis of cancer of unknown primary (CUP) with metastasis of the cervical lymph nodes and the ovary.

Case presentation
A 67-year-old woman with cervical lymphadenopathy was referred to our hospital. Computed tomography showed left cervical lymphadenopathy and bilateral ovarian enlargement. Endoscopic survey revealed no signs of malignancy in the upper or the lower gastrointestinal tract. Pathological findings after cervical lymphadenectomy revealed a signet-ring cell carcinoma and were suggestive of gastric cancer metastases. However, multiple evaluations yielded no evidence of gastric cancer and the patient was diagnosed with CUP. She was prescribed chemotherapy for gastric cancer and underwent bilateral oophorectomy after undergoing chemotherapy for 18 months. Pathologic analysis of oophorectomy tissue revealed findings identical to those seen in the cervical lymph nodes. At about 2 years after the initial diagnosis, an esophagogastroduodenoscopy revealed evidence of gastric cancer. We performed a distal gastrectomy with D2 lymphadenectomy. Her postoperative course was uneventful and she remains alive with no signs of disease recurrence at 3 months post-surgery.

Conclusions
To the best of our knowledge, this is the first report describing successful conversion surgery for stage IV gastric cancer in a patient whose cancer was definitively diagnosed 2 years after an initial diagnosis of CUP.
External limiting membrane: retinal structural barrier in diabetic macular edema
Authors: Saxena Sandeep , Akduman Levent , Meyer Carsten H. 
Published: March 2021

AbstractAdvances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.
Anesthetic management for mastectomy and total hysterectomy in a 49-year-old woman with type 1 sialidosis: a case report
Authors: Furuya Tomonori , Itagaki Masumi , Sugaya Nami , Iida Ryoji , Maeda Takeshi , Suzuki Takahiro 
Published: March 2021

Abstract
Background
Sialidosis is an autosomal recessive glycoprotein storage disorder, caused by neuraminidase deficiency which leads to abnormal intracellular accumulation and urinary excretion of sialylated oligosaccharides, resulting in various morphological and functional disorders. Only a few reports have described the anesthetic managements of patients with sialidosis.

Case presentation
A 49-year-old woman with type 1 sialidosis suffered from all limb contractures, an ocular cherry-red spot, and myoclonic seizures of the limbs. She had been cognitively normal. She was separately scheduled for mastectomy under total intravenous anesthesia and total hysterectomy under combined general and epidural anesthesia uneventfully.

Conclusions
Our patient with type 1 sialidosis received both general and epidural anesthesia uneventfully. Anesthesiologists should carefully assess patients with sialidosis and give careful consideration to individually tailored anesthetic managements.
Translational simulation: from description to action
Authors: Nickson Christopher Peter , Petrosoniak Andrew , Barwick Stephanie , Brazil Victoria 
Published: March 2021

AbstractThis article describes an operational framework for implementing translational simulation in everyday practice. The framework, based on an input-process-output model, is developed from a critical review of the existing translational simulation literature and the collective experience of the authors’ affiliated translational simulation services. The article describes how translational simulation may be used to explore work environments and/or people in them, improve quality through targeted interventions focused on clinical performance/patient outcomes, and be used to design and test planned infrastructure or interventions. Representative case vignettes are used to show how the framework can be applied to real world healthcare problems, including clinical space testing, process development, and culture. Finally, future directions for translational simulation are discussed. As such, the article provides a road map for practitioners who seek to address health service outcomes using translational simulation.
Native Philippine Heterorhabditis indica isolates from banana and rice fields and preliminary results of their virulence against the larvae of super worm (Zophobas morio Fabricius Coleoptera: Tenebrionidae)
Authors: Navarez Mara Louisa , Sangcopan Regina , Aryal Sitaram , Sumaya Neil Pep Dave , Bhat Aashaq Hussain , Sumaya Nanette Hope 
Published: March 2021

Abstract
Background
Entomopathogenic nematodes (EPNs) of the families Heterorhabditidae and Steinernematidae are used as biological control agents of several insect pests in lieu of synthetic pesticides.

Results
Using an insect-baiting technique, naturally occurring EPN isolates were collected from banana and rice fields in the municipality of Hagonoy, the Philippines. A total of 4 isolates were recovered from all the sites namely, HBP1, HBP2, HR3 and HR4. By combining morphometrical and ITS rDNA data, all the isolates were identified as Heterorhabditis indica. To initially assess their infectivity, virulence tests were conducted on the last instar larvae of the super worm, Zophobas morio Fabricius (Coleoptera: Tenebrionidae), the model insect. HR3 isolate had the highest percentage mortality (56%), followed by HBP1 and HBP2 (33%), which were comparable to the available nematode in the market, Heterorhabditis bacteriophora (44%), whereas the lowest was obtained in HR4 isolate (11%).

Conclusions
This study accounted 4 more H. indica isolates in addition to pre-existing isolates in the country, expanding its habitat range and geographic distribution. This also provides baseline information on the potential biocontrol utilization of native EPNs against soil-dwelling insect pests of agricultural crops. Further investigations are required to assess their efficacy against several other insect pests of economic importance for the integrated pest management (IPM) programmes in the country.
Clinical predictors to cognitive impairment in multiple sclerosis patients
Authors: Elshebawy Haidy , Fahmy Ebtesam Mohamed , Elfayoumy Nervana Mohamed , Abdelalim Ahmed Mohamed , Ismail Rania Shehata 
Published: March 2021

Abstract
Background
Cognitive dysfunction is increasingly recognized in multiple sclerosis, even in the early phase of the disease. Multiple sclerosis patients with even mild cognitive deficits may experience greater difficulties in social contact and daily activities, irrespective of physical handicap. This study aimed to estimate clinical predictors of cognitive dysfunction in a sample of Egyptian people with MS.

Results
Significant worse performance in assessed cognitive scales was observed in people with MS as compared to controls. This was related to low educational level, long disease duration, initial cerebellar and motor attacks, progressive course, frequent relapses, and immunosuppressive medications. Cognitive assessment scales were significantly negatively correlated with disability measured by Expanded Disability Status Scale (EDSS) scores.

Conclusion
Predictors of cognitive impairment in people with MS were low educational level, longer disease duration, type of initial attack, frequent relapses, progressive form, higher clinical disability, and immunosuppressive treatment.
Investigating the performance gap between testing on real and denoised aggregates in non-intrusive load monitoring
Authors: Klemenjak Christoph , Makonin Stephen , Elmenreich Wilfried 
Published: March 2021

AbstractPrudent and meaningful performance evaluation of algorithms is essential for the progression of any research field. In the field of Non-Intrusive Load Monitoring (NILM), performance evaluation can be conducted on real-world aggregate signals, provided by smart energy meters or artificial superpositions of individual load signals (i.e., denoised aggregates). It has long been suspected that testing on these denoised aggregates provides better evaluation results mainly due to the fact that the signal is less complex. Complexity in real-world aggregate signals increases with the number of unknown/untracked loads. Although this is a known performance reporting problem, an investigation into the actual performance gap between real and denoised testing is still pending. In this paper, we examine the performance gap between testing on real-world and denoised aggregates with the aim of bringing clarity into this matter. Starting with an assessment of noise levels in datasets, we find significant differences in test cases. We give broad insights into our evaluation setup comprising three load disaggregation algorithms, two of them relying on neural network architectures. The results presented in this paper, based on studies covering three scenarios with ascending noise levels, show a strong tendency towards load disaggregation algorithms providing significantly better performance on denoised aggregate signals. A closer look at the outcome of our studies reveals that all appliance types could be subject to this phenomenon. We conclude the paper by discussing aspects that could be causing these considerable gaps between real and denoised testing in NILM.
Identity and prevalence of wheat damping-off fungal pathogens in different fields of Basrah and Maysan provinces
Authors: Abass Mohammed Hamza , Madhi Qusai Hattab , Matrood Abdulnabi Abdul Ameer 
Published: March 2021

Abstract
Background
Wheat is the most consumed cereal crops in the world infected by several pathogens and pests causing significant losses. The most threatening pathogens are fungi which cause serious diseases on roots, leaves and heads as one of the most threatening pathogens in specific wheat-growing countries. This study aimed to identify and evaluate the prevalence of damping-off fungal pathogens in different wheat fields at Basra and Maysan provinces.

Results
Disease incidence determination and fungal isolation were carried out from two sites at Basra province (Al-Qurna and Al-Madinah) and three sites at Maysan province (Al-Amarah, Kumit, Ali Al Sharqi and Ali Al Gharbi). Al-Qurna fields had the highest disease incidence (32%), while Ali-Alsharqi fields had the lowest one (11%). Fourteen fungal genera were identified. Rhizoctonia solani had the highest appearance (21.6) and frequency (20.20%) percentages followed by Fusarium solani (16.11,14.01) percentages and Macrophomina phaseolina (12.2,11.1) percentages. Seed treatment with R. solani (Rs1 isolate) showed significant decrease in germination (56.6%) compared to F. solani and M. phaseolina treatments. Seed treatment with R. solani (Rs1 isolate) showed significant decrease in germination (56.6%) compared to F. solani and M. phaseolina treatments.

Conclusions
These results revealed the prevalence of wheat damping-off disease in all examined fields at both Basra and Maysan province; the highest disease incidence was seen in Basra wheat fields (Al-Qurna fields); the identification of fungal pathogens showed that the most isolated fungus was R. solani followed by F. solani and M. phaseolina. Laboratory experiments showed the pathogenicity of isolated fungi which varied according to the isolate type.
Adapting the Comprehensive Unit Safety Program (CUSP) implementation strategy to increase delivery of evidence-based cardiovascular risk factor care in community mental health organizations: protocol for a pilot study
Authors: McGinty Emma Elizabeth , Thompson David , Murphy Karly A. , Stuart Elizabeth A. , Wang Nae-Yuh , Dalcin Arlene , Mace Elizabeth , Gennusa Joseph V. , Daumit Gail L. 
Published: March 2021

Abstract
Background
People with serious mental illnesses (SMI) such as schizophrenia and bipolar disorder experience excess mortality driven in large part by high rates of poorly controlled and under-treated cardiovascular risk factors. In the USA, integrated “behavioral health home” models in which specialty mental health organizations coordinate and manage physical health care for people with SMI are designed to improve guideline-concordant cardiovascular care for this group. Such models have been shown to improve cardiovascular care for clients with SMI in randomized clinical trials, but real-world implementation has fallen short. Key implementation barriers include lack of alignment of specialty mental health program culture and physical health care coordination and management for clients with SMI and lack of structured protocols for conducting effective physical health care coordination and management in the specialty mental health program context. This protocol describes a pilot study of an implementation intervention designed to overcome these barriers.

Methods
This pilot study uses a single-group, pre/post-study design to examine the effects of an adapted Comprehensive Unit Safety Program (CUSP) implementation strategy designed to support behavioral health home programs in conducting effective cardiovascular care coordination and management for clients with SMI. The CUSP strategy, which was originally designed to improve inpatient safety, includes provider training, expert facilitation, and implementation of a five-step quality improvement process. We will examine the acceptability, appropriateness, and feasibility of the implementation strategy and how this strategy influences mental health organization culture; specialty mental health providers’ self-efficacy to conduct evidence-based cardiovascular care coordination and management; and receipt of guideline-concordant care for hypertension, dyslipidemia, and diabetes mellitus among people with SMI.

Discussion
While we apply CUSP to the implementation of evidence-based hypertension, dyslipidemia, and diabetes care, this implementation strategy could be used in the future to support the delivery of other types of evidence-based care, such as smoking cessation treatment, in behavioral health home programs. CUSP is designed to be fully integrated into organizations, sustained indefinitely, and used to continually improve evidence-based practice delivery.

Trial registration
ClinicalTrials.gov, NCT04696653. Registered on January 6, 2021