bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature and Rainfall Partial Trends in Oxford, 1870-2019
Authors: Şişman Eyüp , KIZILÖZ Burak 
Published: March 2021

Abstract
In this study, the trends and stabilities of temperature and precipitation hydro-meteorology time series recorded since 1870 in Oxford city of England were analyzed in detail. The Innovative Triangular Trend Analysis (ITTA) method has been inspired to identify and analyze the trends and stabilities of the selected time series. To compare the results obtained by the above-mentioned method, the Classical Mann Kendall (MK) method has been applied to each series determined for ITTA design. Thanks to the innovative design of ITTA which is preferred by the Classic MK and Sen slope methods, the trends of time series could be analyzed in detail. In this study, the first draft structure has been improved with the help of ± 5-±10 % percentage change levels which were added to the ITTA method, and thus more objective evaluations about the trend magnitudes in time series is possible. For the same draft, the monotonic trend slopes which were found by the classical MK were also calculated through the Sen slope method. The data trends could explain in more detail with the help of the draft used in this study, compared to the studies in the literature. Climate change, which has been the most important factor in trend formation in recent years, has been taken into consideration while determining the design series. The thirty-year period up to 2019, a year in which the climate change was felt much more, constitutes the most important reference years for the analysis beginning from 1990, a year in which the climate change effects started to emerge. When the data trends of one hundred fifty years are examined for the different sub-time series, it is seen that the temperature increase in during1990-2019 period is much higher than the past hundred and twenty years, according to the analysis results. The highest average precipitation occurred in the 1990–2019 and 1900–1929 periods, and their amounts and patterns are nearly similar.
Association of Single Nucleotide Polymorphisms With Insulin Secretion, Insulin Sensitivity, and Diabetes in Women With a History of Gestational Diabetes Mellitus
Authors: Prasad Rashmi , Kristensen Karl , Katsarou Anastasia , Shaat Nael 
Published: March 2021

Abstract
Aims: This study investigated whether single nucleotide polymorphisms (SNPs) reported by previous genome-wide association studies (GWAS) to be associated with impaired insulin secretion, insulin resistance, and/or type 2 diabetes are associated with disposition index, the homeostasis model assessment of insulin resistance (HOMA-IR), and/or development of diabetes following a pregnancy complicated by gestational diabetes mellitus (GDM).Methods: Seventy-two SNPs were genotyped in 374 women with previous GDM from Southern Sweden. An oral glucose tolerance test was performed 1–2 years postpartum, although data on the diagnosis of diabetes were accessible up to 5 years postpartum. HOMA-IR and disposition index were used to measure insulin resistance and secretion, respectively. Results: The risk A-allele in the rs11708067 polymorphism of the adenylate cyclase 5 gene (ADCY5) was associated with decreased disposition index (beta = -0.90, SE 0.38, p = 0.019). This polymorphism was an expression quantitative trait loci (eQTL) in islets for both ADCY5 and its antisense transcript. The risk C-allele in the rs2943641 polymorphism, near the insulin receptor substrate 1 gene (IRS1), was associated with increased HOMA-IR (beta = 0.36, SE 0.18, p = 0.050), and the T-allele of the rs4607103 polymorphism, near the ADAM metallopeptidase with thrombospondin type 1 motif 9 gene (ADAMTS9), was associated with postpartum diabetes (OR = 2.12, SE 0.22, p = 0.00055). All analyses were adjusted for age, body mass index, and ethnicity.Conclusions: This study demonstrated the genetic susceptibility of women with a history of GDM to impaired insulin secretion and sensitivity and, ultimately, to diabetes development.
A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria.
Authors: Chang Hung-Ju , Zuniga Ana , Conejero Ismael , Voyvodic Peter , Gracy Jerome , Fajardo-RUiz Elena , Cohen-Gonsaud Martin , Cambray Guillaume , Pageaux Georges-Philippe , Meszaros Magadalena , Meunier Lucy , Bonnet Jerome 
Published: March 2021

Abstract
Bacterial biosensors, or bactosensors, are promising field-deployable agents for medical and environmental diagnostics. However, the lack of scalable frameworks to systematically program ligand detection limits their applications. Here we present a synthetic receptor platform, termed EMeRALD (Engineered Modularized Receptors Activated via Ligand-induced Dimerization) which supports the modular assembly of sensing modules onto a high-performance, generic signaling scaffold controlling gene expression in E. coli. We applied EMeRALD to detect bile salts, a biomarker of liver dysfunction, by repurposing sensing modules from enteropathogenic Vibrio species. We improved the sensitivity and lowered the limit-of-detection of the sensing module by directed evolution. We then engineered a colorimetric bactosensor detecting pathological bile salt levels in serum from patients having undergone liver transplant, providing an output detectable by the naked-eye. The EMeRALD technology enables functional exploration of natural sensing modules and rapid engineering of synthetic receptors for diagnostics, environmental monitoring, and control of therapeutic microbes.
A New Multi-level Algorithms for Balanced Partition Problem on Large Scale Directed Graphs
Authors: Li Xianyue , Pang Yufei , Zhao Chenxia , Liu Yang , Dong Qingzhen 
Published: March 2021

Abstract
Graph partition is a classical combinatorial optimization and graph theory problem, and it has a lot of applications, such as scientific computing, VLSI design and clustering etc. In this paper, we study the partition problem on large scale directed graphs under a new objective function, a new case of graph partition problem. We firstly propose the modeling of this problem, then design an algorithm based on multi-level strategy and recursive partition method, and finally do a lot of simulation experiments. The experimental results verify the stability of our algorithm and show that our algorithm has the same good performance as METIS. In addition, our algorithm is better than METIS on unbalanced ratio.
WITHDRAWN: Supplementation With Purple Corn Anthocyanin Improves Growth Performance, Meat Quality, Muscle Antioxidant Status and Unsaturated Fatty Acid Profiles in Growing Goat
Authors: Tian Xingzhou , Li Jiaxuan , Zhou Di , Luo Qingyuan , Wang Xu , Lu Qi , Chen Xiang 
Published: March 2021

Abstract
Background: There are abundant anthocyanin compounds in purple corn, which has a wide range of biological activity in terms of antioxidation, scavenging free radicals, and preventing lipid peroxidation. However, the impact of anthocyanins on the meat quality, muscle antioxidant activity and fatty acid profiles in growing goats has not been studied. This experiment was conducted to observe the effects of anthocyanin from purple corn pigment (PCP) on growth performance, nutrient digestibility, meat quality, muscle antioxidant activity and fatty acid profiles of goats during the growing period. It aimed to provide the important rationale for anthocyanin preventing lipid peroxidation in goats.Results: A total of eighteen Qianbei Ma wether kids (body weight, 21.38 ± 1.61 kg; mean ± standard deviation) were randomly allotted into three groups using a completely randomized design with six duplicates per group. The dietary treatments were: 1) the control group was provided with basal diet; 2) treatment 1 (LA) was provided basal diet with 0.5 g/d PCP; and 3) treatment 2 (HA) was provided basal diet with 1 g/d PCP. The results showed that supplementation of PCP anthocyanin could increase (P < 0.05) CP and GE digestibilities compared to the control. The addition of PCP tended to drop (P < 0.05) shear force during the growing goat phase. Goat receiving PCP showed higher (P < 0.05) levels of reduced glutathione, DPPH scavenging activity, and peroxidase in Longissimus dorsi muscle (LD) relative to the control. Compared with the control, LA and HA displayed lower (P < 0.05) concentrations C10:0, C12:0, C14:0, C15:0, C16:0, C17:0 and saturated fatty acid (SFA), but increased (P < 0.05) various individual unsaturated FA of C14:1, C16:1, C17:1, C18:1n9, C18:1n12, C18:2n6, C18:3n3, C20:4n6, C22:1n9, C22:4, C22:5n6, C22:6n3, C24:1, PUFA, n-6 PUFA, MUFA/SFA and PUFA/SFA. Specifically, some stronger (P < 0.05) positive correlations were detected between antioxidant status and UFA profiles (GSH-Px, GSH, catalase, DPPH scavenging activity with C14:1, C15:1, C16:1, C18:1n9, C20:4n6, C22:1n9, C22:4, C22:5n6, C24:1, MUFA) in LD of goats.Conclusion: Results indicated that anthocyanin could be used as a source of natural functional additive because anthocyanin-rich PCP had the potential to improve growth performance, meat quality, and enhance muscle antioxidant status and unsaturated FA profiles in the growing goats.
FAP-Imaging in Rare Cancer Entities - First Clinical Experience in a Broad Spectrum of Malignancies
Authors: Dendl Katharina , Finck Rebecca , Giesel Frederik Lars , Kratochwil Clemens , Lindner Thomas , Mier Walter , Cardinale Jens , Kesch Claudia , Röhrich Manuel , Rathke Hendrik , Gampp Heike , Ristau Jonas , Adeberg Sebastian , Jäger Dirk , Debus Jürgen , Haberkorn Uwe , Koerber Stefan Alexander 
Published: March 2021

Abstract
Purpose: 68Ga-FAPI (fibroblast activation protein inhibitor) is a rapidly evolving and highly promising radiotracer for PET/CT imaging, presenting excellent results in a variety of tumor entities, particularly in epithelial carcinomas. This retrospective analysis sought to evaluate the potential and impact of FAPI-PET/CT in rare cancer diseases with respect to improvement in staging and therapy, based on tracer uptake in normal organs and tumors.Material and Methods: 55 patients with rare tumor entities, defined by a prevalence of 1 person out of 2000 or less, received a 68Ga-FAPI-PET/CT scan. 14 women and 41 men (median age 60) were included within the following subgroups: cancer of unknown primary (n=10), head-and-neck-cancer (n=13), gastro-intestinal and biliary-pancreatic cancer (n=17), urinary tract cancer (n=4), neuroendocrine cancer (n=4) and others (n=7). Tracer uptake was quantified by standardized uptake values SUVmax and SUVmean and the tumor-to-background ratio (TBR) was determined (SUVmax tumor/ SUVmean organ). Results: In 20 out of 55 patients the primary tumor was identified and 31 patients presented metastases (n=88), characterized by a high mean SUVmax in primary (10.1) and metastatic lesions (7.6). Highest uptake was observed by liver metastases (n=6) with a mean SUVmax of 9.8 and a high TBR of 8.7, closely followed by peritoneal carcinomatosis (n=16) presenting a mean SUVmax of 9.8 and an excellent TBR of 29.6. In terms of the included subgroups the highest uptake regarding mean SUVmax was determined in gastro-intestinal and biliary-pancreatic cancer with 9.8 followed closely by urinary tract cancer with 9.5 and head-and-neck cancer (9.1). Conclusion Due to excellent tumor visualization and, thereby, sharp contrasts in terms of high TBRs in primary and metastatic lesions in different rare malignancies, 68Ga-FAPI-PET/CT crystallizes as a powerful and valuable imaging tool, particularly with respect to epithelial carcinomas, and therefore an enhancement to standard diagnostics imaging methodologies. The realization of further and prospective studies is of large importance to confirm the potential of FAP-imaging in oncology.
Emerging New Climate Extremes Over Europe
Authors: Ossó Albert , Allan Richard P. , Hawkins Ed , Shaffrey Len , Maraun Douglas 
Published: March 2021

Abstract
Human society and natural systems are intrinsically adapted to the local climate mean and variability. Therefore, changes relative to the local expected variability are highly relevant for assessing impact and planning for adaptation as the climate changes. We analyse the emerging climate signal relative to the diagnosed internal variability (signal-to-noise ratio, S/N) of a set of recently published climate indices over Europe. We calculate the signal-to-noise ratio with respect to a recent baseline (1951-1983) which relates to recent societal experience. In this framework, we find that during the 2000-2016 period, many areas of Europe already experienced significant changes in climate extremes, even when compared to this recent period which is within living memory. In particular, the S/N of extreme temperatures is larger than 1 and 2 over 34% and 4% of Europe, respectively. We also find that about 15% of Europe is experiencing more intense winter precipitation events, while in summer, 7% of Europe is experiencing stronger drought-inducing conditions.
Development of Retinal Degenerative Model Using Lead Acetate (PbAc) in Zebrafish: Morphological and Behavioral Aspects
Authors: Garg Vincy , Kaur Ravneet 
Published: March 2021

Abstract
Lead intoxication reduces cGMP phosphodiesterase activity and enhances the influx of Ca2+ in photoreceptor cells that trigger ATP loss. Thus, releasing proapoptotic factors and activating caspase cascade results in retinal cell apoptosis. In the current study, lead acetate (PbAc) induced retinal degenerative model which mimics ocular degenerative disorders like macular degeneration and retinitis pigmentosa. Qualitative and quantitative analysis of retinal histology, with dose and time response parameters, showed 0.08mg/L concentration for 15 days of treatment was the appropriate dose to develop the retinal degeneration model. Its intoxication affected the photoreceptor cells thus contributing to above mentioned disorders. At an ultrastructural level, it was observed that PbAc induce retinal degeneration by damaging outer and inner segments of the photoreceptors especially the rod cells. Escape response behavior also showed a significant decrease in visual response to changing contrasts. Thus, PbAc was inducing degeneration of retina between pigmented epithelium and photoreceptor layer for further retinal regenerative studies. Lead intoxication reduces cGMP phosphodiesterase activity and enhances the influx of Ca2+ in photoreceptor cells that trigger ATP loss. Thus, releasing proapoptotic factors and activating caspase cascade results in retinal cell apoptosis. In the current study, lead acetate (PbAc) induced retinal degenerative model which mimics ocular degenerative disorders like macular degeneration and retinitis pigmentosa. Qualitative and quantitative analysis of retinal histology, with dose and time response parameters, showed 0.08mg/L concentration for 15 days of treatment was the appropriate dose to develop the retinal degeneration model. Its intoxication affected the photoreceptor cells thus contributing to above mentioned disorders. At an ultrastructural level, it was observed that PbAc induce retinal degeneration by damaging outer and inner segments of the photoreceptors especially the rod cells. Escape response behavior also showed a significant decrease in visual response to changing contrasts. Thus, PbAc was inducing degeneration of retina between pigmented epithelium and photoreceptor layer for further retinal regenerative studies.
Evolution Under Domestication of Correlated Attributes in Two Edible Columnar Cacti in Mexico
Authors: Bravo-Avilez David , Zavala-Hurtado José Alejandro , Rendón Beatriz 
Published: March 2021

Abstract
Stenocereus pruinosus and S. stellatus are columnar cacti from central Mexico, distributed in the Valle de Tehuacán and the Mixteca Baja regions. Both species have populations subject to three different forms of human management: wild, in situ and cultivated, growing in sympatry. The objectives of the present study were to compare variation in damage levels, defense mechanisms and fitness components between 1) both species due to differences in the intensity of management; 2) populations of both species subject to different forms of management; 3) two regions with different management practices and physical conditions, in these two columnar cacti. We estimated the percentage of damage, abundance of spines as resistance, and branching rate as a tolerance component, number of fruits produced in one year, number of seeds per fruit and percentage of seed germination as fitness components. The differences between species, forms of management and regions were estimated with ANOVA tests. A paired correlation with the measured variables within each form of management was used to observe the correlated attributes in both species. We found differences between species, forms of management and regions, mostly concordant with the domestication syndromes. More managed populations, present more damage and less resistance, without compromising fitness, which is the target attribute. Correlated attributes exhibited significant correlations in both species and forms of management. Some of them were concordant with domestication syndrome: More damage/less resistance, or more damage/more branching rate. Our results show that human management can influence the evolution of the interaction of correlated attributes like defense mechanisms, damage and fitness in these columnar cacti.
Lifetime Prevalence and Risk Factors for Perinatal Depression in a Large Cohort of Women with Depression
Authors: Kiewa Jacqueline , Meltzer-Brody Samantha , Milgrom Jeanette , Bennett Elizabeth , Mackle Tracey , Guintivano Jerry , Hickie Ian B , Colodro-Conde Lucía , Medland Sarah , Martin Nicholas G , Wray Naomi R , Byrne Enda M 
Published: March 2021

Abstract
BackgroundHistory of psychiatric disorders, particularly depression, is the strongest risk factor for perinatal depression (PND). Yet many women without such history experience their first depression episode perinatally, whilst other women with depression history do not experience any episodes during the perinatal period. PND may itself be heterogenous, according to differences in psychiatric history. However, a comprehensive investigation of characteristics of women with PND, with and without a prior psychiatric history, has not been attempted.MethodsIn a large sample of parous women with depression, we sought to identify risk factors associated with PND after previous depression episodes, or as first-onset depression. Using data from the Australian Genetics of Depression Study, we identified two subgroups of PND cases (Edinburgh Postnatal Depression Scale score >= 13) with and without prior depression history. For both subgroups, we investigated lifetime prevalence, length and severity of PND. Logistic regression compared a range of characteristics of cases to those of a comparison group with major depression without any perinatal episodes. ResultsCriteria for PND was met by 5,058 (70%) of 7,182 parous women who met criteria for major depression. Of women reporting depression onset before first pregnancy, 2,261 (77%) PND cases were compared to 672 (23%) without PND. Among women reporting their first depression episode during or after their first pregnancy, 878 women for whom this first episode was PND were compared to 2,124 parous women who had experienced depression but never perinatally. Of women who experienced depression prior to first pregnancy, PND cases were significantly more likely to report more episodes of depression (OR=1.1 per additional depression episode, CI=[1.1-1.1], P=1.3E-13), non-European ancestry (OR=1.8, CI=[1.3-2.5], P=1.2E-03), severe nausea during pregnancy (OR=1.3, CI=[1.1-1.6], P=6.6E-03) and emotional abuse (OR=1.4, CI=[1.1-1.7], P=2.0E-03). Women without any depression before their first perinatal episode were significantly more likely to report emotional abuse (OR=1.3, CI=[1.1-1.6], P=1.1E-02) than women with depression without PND.ConclusionsThe majority of parous women in this study experienced PND, associated with more complex, severe depression. Results highlight the importance of perinatal assessments of depressive symptoms, particularly for women with a history of depression or childhood adverse experiences.
A Systematic Review of the Patient Burden of Crohn’s Disease-related Rectovaginal and Anovaginal Fistulas
Authors: Iglay Kristy , Bennett Dimitri , Kappelman Michael , Thai Sydney , Aldridge Molly , Karki Chitra , Cook Suzanne 
Published: March 2021

Abstract
BackgroundCrohn’s disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic literature review (SLR) assessed the burden of Crohn’s-related RVF and AVF, summarizing evidence from observational studies and highlighting knowledge gaps.MethodsThis SLR identified articles in PubMed and Embase that provide data and insight into the patient experience and disease burden of Crohn’s-related RVF and AVF. Two trained reviewers used pre-specified eligibility criteria to identify studies for inclusion and evaluate risk of bias using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies.ResultsOf the 582 records identified, 316 full-text articles were assessed, and 16 studies met a priori eligibility criteria and were included. Few epidemiology studies were identified, with one study estimating the prevalence of RVF to be 2.3% in females with Crohn’s disease. Seven of 12 treatment pattern studies reported that patients had or required additional procedures before and/or after the intervention of interest, demonstrating a substantial treatment burden. Seven of 11 studies assessing clinical outcomes reported fistula healing rates between 50% and 75%, with varying estimates based on population and intervention.ConclusionsThis SLR reports the high disease and treatment burden of Crohn’s-related RVF and AVF and identifies multiple evidence gaps in this field. The literature lacks robust, generalizable data, and demonstrates a compelling need for substantial, novel research into these rare and debilitating sequelae of CD.RegistrationThe PROSPERO registration number for the protocol for this systematic literature review is CRD42020177732.
Descriptions of the mechanical behaviour of the Xigeda formation in Zhaizi village, Yunnan Province, China
Authors: Fu Xiaodong , Du Yuxiang , Sheng Qian 
Published: March 2021

Abstract
The Xigeda formation is a set of Cenozoic lacustrine semi-rock discontinuously distributed in Southwest China. As a typical hard soil or soft/weak rock, the Xigeda formation causes problems when encountered in engineering practice due to its previously unknown mechanical behaviour. Typical samples taken from Zhaizi village along the Jinsha River have been studied. Influences of both the water content and the confining pressure on strength indices of the Xigeda formation were investigated by performing triaxial tests, and the statistical correlations between the shear strength index and the water content of the Xigeda formation, and its soft rock and soil are analysed. By introducing the tenets of the theory of damage mechanics, a damage constitutive model for the deformation of the Xigeda formation and the influence of the water content thereon was established. The results show that: (a) the peak strength, the cohesion and the friction angle decrease linearly with increasing water content; (b) the sensitivity of cohesion to water content is ranked (in ascending order) as: soft rock, the Xigeda formation, then soil, and the sensitivity of friction angle to water content is ranked (in ascending order) as: soil, the Xigeda formation, then soft rock; (c) the damage constitutive model requires few input variables, has a simple form, and can reflect the deformation and strength characteristics of the Xigeda formation under different confining pressures and water contents. The results provide a mechanism with which to understand and model (for both theoretical study and engineering application) the Xigeda formation.