bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial
Authors: Kadauke Stephan , Myers Regina M. , Li Yimei , Aplenc Richard , Baniewicz Diane , Barrett David M. , Barz Leahy Allison , Callahan Colleen , Dolan Joseph G. , Fitzgerald Julie C. , Gladney Whitney , Lacey Simon F. , Liu Hongyan , Maude Shannon L. , McGuire Regina , Motley Laura S. , Teachey David T. , Wertheim Gerald B. , Wray Lisa , DiNofia Amanda M. , Grupp Stephan A. 
Published: January 2021

PURPOSETo prospectively evaluate the effectiveness of risk-adapted preemptive tocilizumab (PT) administration in preventing severe cytokine release syndrome (CRS) after CTL019, a CD19 chimeric antigen receptor T-cell therapy.METHODSChildren and young adults with CD19-positive relapsed or refractory B-cell acute lymphoblastic leukemia were assigned to high- (≥ 40%) or low- (< 40%) tumor burden cohorts (HTBC or LTBC) based on a bone marrow aspirate or biopsy before infusion. HTBC patients received a single dose of tocilizumab (8-12 mg/kg) after development of high, persistent fevers. LTBC patients received standard CRS management. The primary end point was the frequency of grade 4 CRS (Penn scale), with an observed rate of ≤ 5 of 15 patients in the HTBC pre-defined as clinically meaningful. In post hoc analyses, the HTBC was compared with a historical cohort of high-tumor burden patients from the initial phase I CTL019 trial.RESULTSThe primary end point was met. Seventy patients were infused with CTL019, 15 in the HTBC and 55 in the LTBC. All HTBC patients received the PT intervention. The incidence of grade 4 CRS was 27% (95% CI, 8 to 55) in the HTBC and 3.6% (95% CI, 0.4 to 13) in the LTBC. The best overall response rate was 87% in the HTBC and 100% in the LTBC. Initial CTL019 expansion was greater in the HTBC than the LTBC ( P < .001), but persistence was not different ( P = .73). Event-free and overall survival were worse in the HTBC ( P = .004, P < .001, respectively). In the post hoc analysis, grade 4 CRS was observed in 27% versus 50% of patients in the PT and prior phase I cohorts, respectively ( P = .18).CONCLUSIONRisk-adapted PT administration resulted in a decrease in the expected incidence of grade 4 CRS, meeting the study end point, without adversely impacting the antitumor efficacy or safety of CTL019.
Mobile Applications: Breaking Barriers to Early Breast and Cervical Cancer Detection in Underserved Communities
Authors: Munoz-Zuluaga Carlos A. , Gallo-Pérez José David , Pérez-Bustos Andrés , Orozco-Urdaneta Mavalynne , Druffel Karen , Cordoba-Astudillo Lida P. , Parra-Lara Luis G. , Velez-Mejia Carolina , El-sharkawy Farah , Zambrano-Vera Katherin , Erazo Raúl H. , King Mary C. , Sardi Armando 
Published: January 2021

BACKGROUND: Although potentially curable with early detection and timely treatment, breast cancer (BC) and cervical cancer (CC) remain leading causes of death for Colombian women. Lack of education, complicated administrative processes, and geographic limitations hinder early cancer detection. Today, technological tools permeate the society and could assess user risk, deliver customized information, and provide care coordination. We evaluated the effectiveness of a free mobile application (mApp) to reach women, understand misconceptions, identify users at risk for BC and/or CC, and coordinate screening tests in Cali, Colombia. METHODS: The mApp was developed and advertised in four healthcare facility waiting rooms. It used educational, evaluative, and risk factor questions followed by brief explanations to assess the population's knowledge, educate on BC and/or CC, and identify users in need of screening test(s). Women who required screening were navigated and enrolled in the national cancer program. RESULTS: From August 2017 to August 2019, 1,043 women downloaded the mApp. BC misconceptions included beliefs that BC can be prevented (87%), obesity does not increase the risk of BC (49%), and deodorant causes BC (17%). CC misconceptions included that pap smears should not be performed while sexually active (64%), vaginal pain is an early sign of CC (44%), and only women contract human papilloma virus (33%). Overall, 29% (303) were identified as at risk and needed a screening test, with 32% (98) successfully screened. DISCUSSION: mApps can identify women at risk for BC and/or CC, detect barriers to early cancer detection, and help coordinate screening test(s). This technology has widespread applications and may be useful in other underserved communities.
Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast
Authors: Scotchman Elizabeth , Kume Kazunori , Navarro Francisco J. , Nurse Paul 
Published: January 2021

ABSTRACT
Fission yeast cells divide at a similar cell length with little variation about the mean. This is thought to be the result of a control mechanism that senses size and corrects for any deviations by advancing or delaying onset of mitosis. Gene deletions that advance cells into mitosis at a smaller size or delay cells entering mitosis have led to the identification of genes potentially involved in this mechanism. However, the molecular basis of this control is still not understood. In this work, we have screened for genes that when deleted increase the variability in size of dividing cells. The strongest candidate identified in this screen was mga2. The mga2 deletion strain shows a greater variation in cell length at division, with a coefficient of variation (CV) of 15–24%, while the wild-type strain has a CV of 5–8%. Furthermore, unlike wild-type cells, the mga2 deletion cells are unable to correct cell size deviations within one cell cycle. We show that the mga2 gene genetically interacts with nem1 and influences the nuclear membrane and the nuclear–cytoplasmic transport of CDK regulators.
PdAg Nanoparticles Supported on an Amine-functionalized MOF as a Photo-switchable Catalyst for Hydrogen Storage/Delivery Mediated by CO2/Formic Acid
Authors: Mori Kohsuke , Matsuo Jumpei , Yamashita Hiromi 
Published: January 2021

Abstract
The effects of depositing Pd alloy nanoparticles (NPs) on an amine-functionalized Fe-metal organic framework (MOF; MIL-88B-NH2) were investigated, with the aim of developing a photo-switchable bifunctional catalyst for hydrogen storage/delivery mediated by CO2/formic acid (FA). The highly dispersed PdAg NPs promoted photocatalytic FA synthesis from CO2 under visible light and inhibited electron-hole recombination by efficiently trapping excited electrons. The release of H2 via the dehydrogenation of FA upon heating was efficiently catalyzed by the electron-rich Pd species generated by alloying with Ag. These Pd species acted as crucial active centers associated with amine-functionalized moieties in the linker groups of the Fe-MOF.
Feasibility of a multiparametric MRI protocol for imaging biomarkers associated with neoadjuvant radiotherapy for soft tissue sarcoma
Authors: Kershaw Lucy , Forker Laura , Roberts Darren , Sanderson Benjamin , Shenjere Patrick , Wylie James , Coyle Catherine , Kochhar Rohit , Manoharan Prakash , Choudhury Ananaya 
Published: January 2021

Objective: Soft tissue sarcoma (STS) is a rare malignancy with a 5 year overall survival rate of 55%. Neoadjuvant radiotherapy is commonly used in preparation for surgery, but methods to assess early response are lacking despite pathological response at surgery being predictive of overall survival, local recurrence and distant metastasis. Multiparametric MR imaging (mpMRI) is used to assess response in a variety of tumours but lacks a robust, standardised method. The overall aim of this study was to develop a feasible imaging protocol to identify imaging biomarkers for further investigation. Methods: 15 patients with biopsy-confirmed STS suitable for pre-operative radiotherapy and radical surgery were imaged throughout treatment. The mpMRI protocol included anatomical, diffusion-weighted and dynamic contrast-enhanced imaging, giving estimates of apparent diffusion coefficient (ADC) and the area under the enhancement curve at 60 s (iAUC60). Histological analysis of resected tumours included detection of CD31, Ki67, hypoxia inducible factor and calculation of a hypoxia score. Results: There was a significant reduction in T1 at visit 2 and in ADC at visit 3. Significant associations were found between hypoxia and pre-treatment iAUC60, pre-treatment ADC and mid-treatment iAUC60. There was also statistically significant association between mid-treatment ADC and Ki67. Conclusion: This work showed that mpMRI throughout treatment is feasible in patients with STS having neoadjuvant radiotherapy. The relationships between imaging parameters, tissue biomarkers and clinical outcomes warrant further investigation. Advances in knowledge: mpMRI-based biomarkers have good correlation with STS tumour biology and are potentially of use for evaluation of radiotherapy response.
Dataset: local government mask orders preceding statewide orders by US states
Authors: Jacobs Philip , Ohinmaa Arvi 
Published: January 2021

We present a database listing local government mask orders for COVID-19 that were enacted between April and September, 2020, prior to the date that the governors issued statewide mask wearing mandates. We obtained data from a Google search of web pages of local and national commercial and public broadcasters and newspapers, and of the orders themselves. In the database, we present data identifying the county, municipality or tribal council, date of the order, and the source’s internet address. In the 34 states with statewide orders, local governments in 21 of these states issued mandates in 218 municipalities, 155 counties, and 1 tribal council. The dataset can be accessed from https://doi.org/10.7939/DVN/NDFEHK
Case Report and Literature Review: COVID-19 and status epilepticus in Dyke-Davidoff-Masson syndrome
Authors: Ibañez Valdés Lourdes de Fátima , Geroge Jerry , Joseph Sibi , Alshmandi Mohamed , Makaleni Wendy , Foyaca Sibat Humberto 
Published: January 2021

Dyke-Davidoff-Masson syndrome (DMMS) is a non-inherited rare condition with a clinical constellation of hemiparesis/hemiplegia, facial asymmetry, intellectual disability, and epilepsy. The radiological features can be including unilateral cerebral atrophy, calvarial thickening, and hyper pneumatization of the paranasal sinuses. The condition can either be congenital or acquired. The presentation usually occurs during childhood or early adolescents, but there have been adult cases reported. Here we report a 48-year-old male who was a known poorly controlled epileptic that contracted SARS-CoV-2 with subsequently developed status epilepticus and, when worked up, was shown to have features of DDMS. This case is unique as the patient had hemiatrophy and epilepsy but managed to lead a normal, physically demanding, and high functioning academic career and presented late in life. Perhaps only due to coronavirus disease 2019 (COVID-19) was this diagnosis picked up. This report contains a case presenting atypical DDMS in status epilepticus and COVID -19 plus other complications. From our knowledge, this is the first case presenting these comorbidities reported to the medical literature.
VELHICE, SEXUALIDADE E AFETO EM DIARIO DA GUERRA DO PORCO, DE ADOLFO BIOY CASARES
Authors: Malloy Letícia 
Published: January 2021

Este artigo objetiva refletir sobre a temática da velhice a partir da análise de Diario da guerra do porco (1969), escrito pelo argentino Adolfo Bioy Casares. Além disso, busca examinar a abordagem conferida a expressões de sexualidade e afeto na idade madura, tomando-se por foco a caracterização de Isidoro Vidal, protagonista do romance. Para tanto, o estudo se vale das perspectivas teóricas de Simone de Beauvoir (2018) acerca da velhice, de Michel Foucault (1979; 1988) a respeito da sexualidade e das relações de poder e de Benedictus de Spinoza (2008) sobre a origem e a natureza dos afetos.
A MORALIZAÇÃO DA MORTE NO THEATRUM SACRUM DE ANTÔNIO VIEIRA
Authors: Oliveira Ana Lúcia Machado de 
Published: January 2021

O presente artigo traz algumas reflexões iniciais sobre o lugar da morte e o florescimento do macabro no imaginário social entre os séculos XVI e XVII, a partir do diálogo com as obras de Delumeau, Arriès, Mâle e Chanu, dentre outros. Em seguida, examina a grande difusão da imagem do corpo na cultura seiscentista, que traz como corolário o papel de destaque da anatomia, a qual transcende o âmbito das práticas médicas e invade outros campos do saber, revestindo-se de sentidos metafóricos, tal como na expressão “anatomia moral”, muito empregada na época.Para abordar o lugar do púlpito na difusão do conceito de morte propagado pelo catolicismo no século XVII, será analisada a obra sermonística do jesuíta Antônio Vieira, tendo como foco a sua construção de um memento mori a partir da retomada do lugar-comum bíblico de que o homem é pó e ao pó voltará, tão reciclado por pregadores e poetas do período. Esse tema escritural é desenvolvido nos três sermões vieirianos da Quarta-Feira de Cinzas, que são discutidos na parte final deste texto.
LIMIARES DO LITERÁRIO: UMA APROXIMAÇÃO ENTRE LLANSOL E LISPECTOR
Authors: Oliveira Maria Lúcia Wiltshire de 
Published: January 2021

Embora a escrita seja um artefato humano que elide ou põe entre parênteses o sujeito, deparamo-nos com situações limítrofes que ao romperem os paradigmas dos gêneros da prosa – no caso aqui, a ficção e as formas confessionais –, revelam dilemas que instabilizam o discurso literário produzido pelo imaginário. Com o objetivo de observar o limiar desta instabilidade, o trabalho pretende revisitar a postulação de diferença entre o literário e o não-literário para refletir sobre as distinções entre narrativa (escrita do outro) e o diário (escrita de si). De modo resumido a análise repousa em dois binômios - real vs. ficcional, eu vs. outro - que serão discutidos frente ao desafio de Blanchot ao sugerir um “lugar da imantação”, passagem que opõe narrativa ao diário. Na perspectiva de Peirce, a imagem é um hipo-ícone ou um quase-ícone que mantém com o real uma relação estreita de semelhança, que garante a sua independência em relação ao real e ao sujeito que supostamente lhe poderiam servir, respectivamente, de cenário prévio ou de suporte autoral. Em torno destes conceitos, pretende-se discutir a imagem como unidade mínima do “belo” e seu efeito do “novo”. O corpus principal de discussão contempla excertos da escrita de duas autoras, extraídos das obras Uma data em cada mão; Livro de Horas I da portuguesa Maria Gabriela Llansol e Um sopro de vida; Pulsações da brasileira de Clarice Lispector.
CYBERL@B AS AN OPEN EDUCATIONAL RESOURCE (OER) FOR LEARNING ENGLISH THROUGH PRACTICE AND COLLABORATION
Authors: Quesada Allen , Díaz-Ducca Jenaro A. 
Published: January 2021

The teaching of English as a Foreign Language (EFL) is a key field in public education in developing countries. In the case of Costa Rica, the free-access EFL platform and Open Education Resource (OER), Cyberl@b (https://cyberlab.ucr.ac.cr), was designed in order to meet public educational needs and policies, and it is targeted towards primary and secondary EFL teaching. In this article, Cyberl@b will be described and analyzed in the light of Laurillard’s concepts of Learning Through Practice (LTP) and Learning Through Collaboration (LTC). Based on these theoretical concepts, basic criteria were extracted in order to evaluate the platform as an educational resource that offers multimedia, synchronous and asynchronous interaction, peer and mentor feedback, as well as affordances for practice and collaboration in the following macro and micro skills: listening, speaking, reading, writing, grammar, pronunciation, and vocabulary. The study concludes that Cyberl@b allows for rich opportunities for practice and collaboration according to LTP and LTC principles for primary and secondary English learners in Costa Rica and around the world.
FORMAÇÃO CONTINUADA DE PROFESSORES: CONTRIBUIÇÕES DA OFICINA PEDAGÓGICA PARA A APRENDIZAGEM DO SOFTWARE SCRATCH
Authors: Bastos Viviane Da Costa 
Published: January 2021

A formação teórica e prática dos docentes pode contribuir para a melhoria da qualidade de ensino e promover a qualificação profissional e pessoal desses sujeitos. Logo, o principal objetivo deste estudo foi apresentar as ações realizadas pelos professores de Inglês que atuam em uma Escola Pública Municipal Bilíngue (Português/Inglês) na cidade do Rio de Janeiro e participaram de uma oficina presencial para a aprendizagem do software Scratch como ferramenta que contribui para a atuação pedagógica. O trabalho, então, situa-se em uma pesquisa qualitativa com abordagem descritiva e interpretativista (GIL, 1999), no qual os dados foram gerados a partir de observações sistemáticas e participantes (RUDIO, 1985) durante a realização da oficina. Os resultados indicam que o software Scratch é um programa que possibilita a criação de espaços de aprendizagem e pode contribuir para a reflexão, o entrelaçamento dos saberes da formação inicial com os da formação continuada, a colaboração e novas práticas do professor.
Optimization, fabrication, and performance analysis of SMF-/MMF-based microfiber ball structure
Authors: Li Muyang , Wang Yu , Zhu Guo , Wang Zhi , Singh Ragini , Zhang Bingyuan , Kumar Santosh 
Published: January 2021

In this paper, four kinds of microfiber ball structure of different sizes, such as 330, 340, 350, and 360 µm were fabricated by single-mode fiber and multimode fiber, respectively. To test its performance, the reflected intensity was measured, and the results showed that the microfiber ball with the largest diameter of 360 µm had the maximum reflected intensity. The 360 µm microfiber ball was characterized by scanning electron microscope. This indicates that compared with a small-diameter microfiber ball, large-diameter microspheres are more suitable to be used as follow-up experimental objects, with the diameter of the fiber ball ranging from 330 to 360 µm.
Reproducibility and normalization of reactive hyperemia using laser speckle contrast imaging
Authors: Shirazi Behnia Rezazadeh , Valentine Rudy J. , Lang James A. 
Published: January 2021

BackgroundImpaired perfusion indices signal potential microvascular dysfunction preceding atherosclerosis and other cardiometabolic pathologies. Post-occlusive reactive hyperemia (PORH), a vasodilatory response following a mechanically induced ischemia, is a transient increase in perfusion and can assess microvascular function. The greatest blood flow change corresponding to the first minute of hyperemia (represented by time-to-peak, hyperemic velocity, AUC within 1stmin) has been shown to indicate microvascular dysfunction. However, the reproducibility of these temporal kinetic indices of the PORH response is unknown. Our aim was to examine the inter- and intra-day reproducibility and standardization of reactive hyperemia, with emphasis on the kinetic indices of PORH, using laser speckle contrast imaging (LSCI) technique.Methods and resultsSeventeen healthy adults (age = 24 ± 3 years) completed three PORH bouts over two lab visits. LSCI region of interest was a standardized 10 cm region on the dominant ventral forearm. A 5-min brachial artery occlusion period induced by inflating an arm cuff to 200 mmHg, preceded a 4-min hyperemic period. Inter- and intra-day reliability and reproducibility of cutaneous vascular conductance (LSCI flux / mean arterial pressure) were determined using intraclass correlation (ICC) and coefficient of variation (CV%). Maximal flow and area under the curve standardized to zero perfusion showed intra- and inter-day reliability (ICC > 0.70). Time to maximal flow (TMF) was not reproducible (inter-day CV = 18%). However, alternative kinetic indices such as 1-min AUC and overshoot rate-of-change (ORC), represented as a piecewise function (at 5s, 10s, 15s, and 20s into hyperemia), were reproducible (CV< 11%). Biological zero was a reliable normalization point.ConclusionPORH measured with LSCI is a reliable assessment of microvascular function. However, TMF or its derived hyperemic velocity are not recommended for longitudinal assessment. Piecewise ORC and 1-min AUC are reliable alternatives to assess the kinetic response of PORH.
Ferroptosis Resistance in Cancer: An Emerging Crisis of New Hope
Authors: Xu Daiyun , Lü Yonghui , Li Yongxiao , Li Shengbin , Wang Zhe , Wang Junqing 
Published: January 2021

Abstract
Ferroptosis, a new mode of nonapoptotic cell death, is increasingly recognized as a new hope in overcoming resistance to chemotherapy in cancer. Both canonical and noncanonical pathways can trigger ferroptosis execution via an iron-dependent lethal lipid peroxidation manner. However, growing evidence has shown that some cancer cells can survive ferroptotic stress through metabolic remodeling as regards iron metabolism, anti-oxidative systems, and lipid metabolism. In addition to the well-known roles of the XC−/glutathione/glutathione peroxidase 4 (XC–/GSH/GPX4) axis in blocking ferroptosis, several recently identified pathways, including the Mevalonate-ferroptosis suppressor protein 1 (MVA-FSP1) axis, the GTP cyclohydrolase 1-Tetrahydrobiopterin (GCH1-BH4) axis, the peroxisome-ether-phospholipid axis, the acyl-CoA synthetase long-chain family member 3-monounsaturated fatty acids (ACSL3-MUFA) axis, and the Liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) axis, can negatively regulate susceptibility to ferroptosis. Prominin-2, a newly identified ferroptosis-modulating protein, also drives cancer cells to escape from ferroptosis induction. These findings collectively led to major challenges and opportunities in the development of novel therapies that target the ferroptosis resistance of cancer cells.

Significance

Ferroptosis is a lethal consequence of accumulated lipid peroxidation catalyzed by ferrous iron and oxygen. This unique cell death process appears to involve many diseases, such as neurodegeneration, ischemia/reperfusion injury, kidney disease, and a druggable target in therapy-resistant cancers. There is great expectation of being able to exploit ferroptosis for the treatment of as yet incurable diseases. However, the state of ferroptosis susceptibility is linked to various regulation pathways. This perspective aims to integrate the current understanding of signaling mechanisms for ferroptotic defenses and facilitates movement toward novel cancer therapeutic strategies.