bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Weathering Well App, A New Low Intensity Digital Mental Health Intervention for Australian Farmers: Formative Research
Authors: Raphiphatthana Buaphrao , Sweet Michelle , Dingwall Kylie , MacDonald Alistair , Nagel Tricia 
Published: March 2021

Abstract
Background

Australian farming communities demonstrate significant resilience in the face of many challenges, including drought, bushfires, and more recently COVID-19. Nevertheless, worries related to financial hardship, farm viability and productivity, and remoteness render the population vulnerable to mental health problems. Despite this vulnerability, people in these communities are unlikely to seek help from mental health services due to attitudes, service access and geographic barriers. A tailored, low intensity digital mental health intervention may provide an acceptable and appropriate early wellbeing intervention for the population and help bridge the mental health service gap.
Objectives

This study has three objectives: 1) to adapt an existing tablet-based, therapist-guided, low intensity digital mental health intervention to address the wellbeing needs of Australian farming communities (development of the Weathering Well app), 2) to adapt, deliver, and evaluate training in utilisation of the new app, and 3) to conduct preliminary analyses on app usage data during the 12-months post-app release.
Methods

An Expert Advisory Group, comprising graziers, growers, rural financial counsellors, rural and remote mental health clinicians, Information Technology (IT) experts, Western Queensland Primary Health Networks representatives, Peak Body representatives (New South Wales rice growers), and drought impacted Shire Council representatives, was established. A three-day co-design workshop facilitated by the research team followed by a series of member-checking and user-testing rounds led to release of the new app. Pre-existing training resources were adapted, and the revised training workshops were delivered to service providers working with remote and rural farming communities. Pre- and post-training evaluations and app usage data were analysed.
Results

The final Weathering Well app received approval for public release by all stakeholders in September 2019. Following training, participant scores suggested that the app was accessible, appropriate, and effective with increased perceived knowledge and confidence in app use post-training. Analysis of app usage data indicated good app engagement, providing additional preliminary evidence for feasibility and acceptability. Trainees indicated reservations in terms of successful implementation most notably the need for organizational support for use.
Conclusions

This study provides an example of an intervention tailored to context through collaborative co-design. The preliminary findings suggest high levels of acceptability, providing a good foundation for implementation, further app revision and exploration of effectiveness and sustainability.
Target Accumulation of Selective Anticancer Depsipeptides by Reconstructing Precursor Supply in Neoantimycins Biosynthetic Pathway
Authors: Zhou Lin , Shen Yaoyao , Chen Nannan , Li Wanlu , Lin Hou-wen , Zhou Yongjun 
Published: March 2021

Abstract
BackgroundNeoantimycins are a group of 15-membered ring depsipeptides isolated from streptomycetes with a broad-spectrum of anticancer activities. Their biosynthesis is directed by the hybrid multimodular megaenzymes of non-ribosomal peptide synthetase and polyketide synthase. We have previously discovered a new neoantimycin analogue unantimycin B, which was demonstrated with selective anticancer activities and was produced from neoantimycins biosynthetic pathway with a starter unit of 3-hydroxybenzoate, instead of the 3-formamidosalicylate for neoantimycins. However, the low fermentation yield and tough isolation procedure have been hindering in-depth pharmacology investigation of unantimycin B as anticancer agents.ResultsIn the work, we genetically constructed two unantimycin B producer strains with neoantimycins production destroyed by removing natO and natJ-L genes essential for 3-formamidosalicylate biosynthesis and therefore facilitated chromatographic separation of unantimycin B from the complex fermentation extract. Based on the △natO mutant, we improved unantimycin Bproduction by two times, reaching to approximate 12.8 mg/L, by feeding 3-hydroxybenzoate in fermentation. Further, the production was improved by more than six times, reaching to approximate 40.0 mg/L, in the △natO strain introduced with a chorismatase gene highly expressed under a strong promoter for over-producing 3-hydroxybenzoate endogenously.ConclusionThe work gives a case of targeting accumulation and significant production improvement of medicinally interesting natural products via genetically manipulation of precursor biosynthesis in streptomycetes, the talented producers of pharmaceutical molecules.
Extraction and Composition of Dissolved Organic Matter in Poyang Lake and Its Effects on Morphological Changes of Heavy Metals
Authors: Li Yuanhang , Sheng Zhaoying , Gong Xiaofeng , Zeng Huiqing , Chen Chunli , Zhang Ru 
Published: March 2021

Abstract
Dissolved organic matter (DOM) is generally thought to impact the bioavailability of heavy metals. However, the source of wetland DOM and its interaction with heavy metals remain poorly understood. Fluorescence excitation emission matrices (EEMs)-fluorescence regional integration (FRI) coupling techniques and chromophoric dissolved organic matter (CDOM) was used to explore the source of DOM of Poyang Lake including water body, soil and plants, and the effects on morphological changes of heavy metals. The results showed that the best DOM extraction effect can be obtained with the soil-water mass ratio 1:10, centrifuged at 4 000 rpm for 30 min, and the 0.45 μm glass fiber filter by orthogonal test. There were four types of peaks of DOM in water body of Poyang Lake, which was input mainly by land source, while six types of peaks (ACTDBE) were observed in soil. Soil DOM is highly humified with large molecular weight. More types of fluorescent peaks were observed in plant and the content of DOM in plants was higher than that of water body and soil due to the plant proteins. The content of fulvic acid was less than tryptophan in DOM of Triarrhena lutarioriparia and Phragmites communis in Longkou, while the opposite were in other samples. Furthermore, pot experiment illustrated that DOM had an activation effect on Cd, Cu and Zn and a passivation effect on Cr and Pb with the increase of DOM content. After the addition of exogenous DOM, Cr, Pb and Zn were immobilized by the function together with DOM and plants, while Cd and Cu were activated.
Enhanced Nitrogen Removal of Wastewater at Low Temperature by Iterative Screening of Cold-Tolerant Denitrifying Bacteria
Authors: Qu Jin , zheng Zhanwang , Zhao Ruojin , Chen Yinyan , Li Yiyi , Jin Peng 
Published: March 2021

Abstract
The biological denitrification for wastewater treatment in winter is often seriously compromised due to the effects of low-temperature (<13 °C) on metabolic activity of microorganism. In this study, an excellent cold-tolerant denitrifying bacterium, Moraxella osloensis LT-01 was isolated by iterative domestication. The strain LT-01 retained about 60% maximal growth activity at 10 °C. Under initial concentrations of 100 mg/L, average ammonium, nitrate and nitrite removal efficiencies for domestic wastewater (C/N 4:1) at 10 °C were 70.35%, 65.39% and 61.74% in 24 h, respectively. Nitrogen balance analysis showed that about 46% of TN was directed toward in the dissimilation form of gas, and 16% of TN was assimilated for cell growth. Key genes hydroxylamine reductase gene (HAO) and nitrite reductase (NirS) involved in nitrification and denitrification processes were identified by gene-specific PCR, indicating that strain LT-01 perform nitrogen removal efficiently via unique simultaneous nitrification and denitrification. These results suggest the bacterium LT-01 has great potential as an effective performer for treating domestic wastewater in winter.
Inserting a Drainage Strip into the Pre-tracheal Space to Treat Tension Pneumomediastinum: A Case-control Study
Authors: Liu Qianli , Wu Song , Hong Chun , Li Xiaohui 
Published: March 2021

Abstract
Background: A Severe tension pneumomediastinum can result in respiratory and circulatory dysfunction. Common etiologies include severe pneumonia such as COVID-19 pneumonia, asthma, excessive pressure from a ventilator, etc. we describe a method for draining tension pneumomediastinum by inserting a drainage strip into the pre-tracheal space.Methods:Design: Case-control.Setting: Data from a medical institution in southern China.Participants: 30 patients with tension pneumomediastinum and comorbid type II respiratory failure.Interventions: 15 patients (surgery group) were treated with a drainage strip being inserted into the pre-tracheal space while other 15 patients (control group) were treated without drainage.Outcome measures: Arterial blood pO2 and pCO2 after 30 minutes and 12 hours of mechanical ventilation, total duration of mechanical ventilation, and chest radiography results after 12 hours of mechanical ventilation.Results: Chest radiography after 12 hours of mechanical ventilation showed that the pneumomediastinum basically disappeared in the surgery group but did not decrease significantly in the control group. The arterial blood pCO2 after 12 hours of mechanical ventilation and total duration of mechanical ventilation were significantly lower in the surgery group than in the control group (95% CI -3.31 to -1.36, p<0.001; 95% CI -5.56 to -2.84, p<0.001), while the arterial blood pO2 after 12 hours of mechanical ventilation was significantly higher in the surgery group than in the control group (95% CI 1.76 to 7.57, p=0.004). There were no significant intergroup differences in other variables. No recurrence occurred in either group during 7–14 days after discharge, and all patients recovered.Conclusions: Our method for draining tension pneumomediastinum improved respiratory function and shortened mechanical ventilation duration.Trial registration: ChiCTR2000039496Data sharing statement: Technical appendix, statistical code, and dataset available from the FigShare repository, https://doi.org/10.6084/m9.figshare.13487295.
Machine Learning Based Luminance Analysis of a µLED Array
Authors: Becker Steven 
Published: March 2021

Abstract
In the past years, the development of µLED arrays gained momentum since they combine the advantages of LEDs, such as high brightness and longevity, with the high resolution of a micro-scaled structure. For their development, spatially resolved measurement of luminance and color of single µLEDs and the entire light-emitting surface are usually analyzed as they quantify the visual perception. However, studying individual µLEDs is time-consuming to measure and evaluate, while examining the entire light-emitting area suffers from interference from non-functioning µLEDs. This paper presents a method to perform both analyzes with a single measurement employing unsupervised machine learning. The results suggest that a precise reconstruction of the µLEDs and a more accurate characterization µLED arrays is achieved.
Reversible Electroporation Study of Realistic Normal and Cancerous Cervical Cells Model Using Avalanche Transistor Based Nanopulse Generator
Authors: Kumar Mayank , Mishra Ashutosh 
Published: March 2021

Abstract
In this paper, we study the reversible electroporation process on the normal and cancerous cervical cell.The 2D contour of the cervical cells is extracted using image processing techniques from the Pap smear image. The conductivity change in the cancer cell model has been used to differentiate the effects of the high-frequency electric field on normal and cancerous cells. The cells modulate themselves when this high-frequency pulse is applied based on the Debye relaxation relation. In order to computationally visualize the effects of the electroporation on the cell membrane Smoluchowski equation calculates the number of pores generated and Maxwell equations are used to determine the Transmembrane potential generated on the membrane of the cervical cell. The results produced demonstrates that this mathematical model perfectly describes the numerical tool to study the normal cells and cancerous cells under the electric field. The electric field is provided with the help of a realistic pulse generator which is designed on the principle of Marx circuit and avalanche transistor-based operations to produce a Gaussian pulse. The paper here use strength duration curve to differentiate the electric field and time in nanoseconds required to electroporate normal and cancerous cells.
Risk factors of pulmonary complications after spine surgery and a risk assessment table was established: a retrospective cohort study
Authors: Zhang HuaXing , Jia Jingde , Chen Jia , Wang Suxing , Du Mengying , Hu Yongbo , Li Wenyi 
Published: March 2021

Abstract
Purpose

To determine the risk factors for pulmonary complications after spine surgery and establish a risk assessment table.
Methods

A total of 627 patients, who underwent spine surgery at Hebei General Hospital from January 2018 to December 2019, were retrospectively collected and studied. Univariate analysis revealed significant variables. Risk factors and the effects of the model were determined by unconditional binary logistic regression analyses and the receiver operating characteristic (ROC) curve, respectively. A risk assessment scale for patients after spine surgery was also established based on the risk factors.
Results

49 patients were diagnosed with pulmonary complications (49/627, 7.81 %). Logistic regression analysis showed that age, body mass index (BMI), smoking, diabetes, type of spinal diseases, type of operation, surgical site, American society of anesthesiologists (ASA) scores, type of anesthesia and total length of stay (LOS) were risk factors of pulmonary complications after spine surgery (P < 0.05) and area under the curve was 0.883, 95 % confidence intervals (CI): 0.843–0.923. The risk assessment table included preoperative and postoperative evaluation indicators. There were 8 preoperative evaluation indicators including age, BMI, smoking, hypertension, diabetes, chronic pulmonary diseases, type of spinal diseases, surgical site. Preoperative hospitalization days, ASA scores, type of anesthesia, type of operation and duration of operation were five postoperative evaluation indicators. The highest assessment score of preoperative is 21, postoperative is 18, and the total is 39 points of all these indicators.
Conclusions

Significant risk factors of pulmonary complications were age, BMI, smoking, diabetes, type of spinal diseases, type of operation, surgical site, ASA scores, type of anesthesia and total LOS after spine surgery. There were 13 evaluation indicators in our established risk assessment table including preoperative and postoperative evaluation indicators. The higher the score, the higher the risk of pulmonary complications after spine surgery.
Multicriterion decision making in groundwater planning
Authors: Gaur Shishir , Srinivasa Raju K. , Nagesh Kumar D. , Bajpai Mayank 
Published: March 2021

Abstract
The groundwater planning problems are often multiobjective. Due to conflicting objectives and non-linearity of the variables involved, several feasible solutions may have to be evolved rather than single optimal solution. In this study, the simulation model built on an Analytic Element Method (AEM) and the optimization model built on a Non-dominated Sorting Genetic Algorithm (NSGA-II) were coupled and applied to study a part of the Dore river catchment, France. The maximization of discharge, the minimization of pumping cost and the minimization of piping cost are the three objectives considered. 2105 non-dominated groundwater planning strategies were generated. K-Means cluster analysis was employed to classify the strategies, and clustering was performed for 3 to 25 clusters. A cluster validation technique, namely Davies–Bouldin (DB) index, was employed to find the optimal number of clusters of groundwater strategies which were found to be 20. Multicriterion Decision-Making (MCDM) techniques, namely VIKOR and TOPSIS, were developed to rank the 20 representative strategies. Both these decision-making techniques preferred representative strategy A5 (piping cost, pumping cost and discharge respectively of 880,000 Euro, 679,000 Euro and 1,263.1 m3/s). The sensitivity analysis of parameter v in VIKOR suggested that there were changes in ranking pattern for various values of v. However, the first position remained unchanged.
Numerical simulation and experimental research of cavitation nozzle based on equation curve
Authors: Wang Lifu , Shi Dongyan , Yang Zhixun , Li Guangliang , Ma Chunlong , He Dongze , Yan Liang 
Published: March 2021

Abstract
To further investigate and improve the cleaning ability of the cavitation nozzle, this paper proposes a new model that is based on the Helmholtz nozzle and with the quadratic equation curve as the outer contour of the cavitation chamber. First, the numerical simulation of the flow field in the nozzle chamber was conducted using FLUENT software to analyze and compare the impact of the curve parameters and Reynolds number on the cleaning effect. Next, the flow field was captured by a high-speed camera in order to study the cavitation cycle and evolution process. Then, experiments were performed to compare the cleaning effect of the new nozzle with that of the Helmholtz nozzle. The study results demonstrate that effective cavitation does not occur when the diameter of the cavitation chamber is too large. For the new nozzle, with the increase of the Reynolds number, the degree of cavitation in the chamber first increases and then decreases; the cleaning effect is much better than that of a traditional Helmholtz nozzle under the same conditions; the nozzle has the best cleaning effect for the stand-off distance of 300 mm.
Contrasting fish biomarker responses between streams with different environmental conditions
Authors: Cotrim Carlos Filipe Camilo , Reis Max Miller Bicudo dos , Teresa Fabrício Barreto , Ondei Luciana De Souza 
Published: March 2021

Streams are environments susceptible to anthropic impacts that harm aquatic organisms by affecting their homeostasis. This study aimed to determine variations in the response of biochemical and genetic biomarkers of fish under the influence of anthropogenic impacts. For this, individuals of the tetra fish Astyanax lacustris were exposed in an impacted stream and one of its non-impacted tributaries (reference) during the dry and rainy seasons. For biochemical analyzes, we evaluated the antioxidant enzymes catalase and glutathione peroxidase and lipid peroxidation in tissue samples of gills and liver. For the genotoxicity test, we evaluated micronuclei and nuclear anomalies in blood samples. The antioxidant enzymes showed seasonal variation, regardless of the stream; lipid peroxidation didn’t differ between seasons or between streams. The frequency of micronuclei and nuclear abnormalities were more frequent in the impacted stream during the rainy season, probably in response to the leaching of toxic compounds that tends to be increased in that season. These results support the use of nuclear biomarkers in biomonitoring programs.
A caminho de uma Filologia das Literaturas do mundo: uma abordagem da obra WeltFraktale
Authors: Schöninger Carla Luciane Klos 
Published: March 2021

Este texto traz uma resenha da obra WeltFraktale: Wege durch die Literaturen der Welt, o qual foi publicado no ano de 2017 e está estruturado em cinco capítulos: Theorie -Auf dem Weg zu einer Philologie der Literaturen der Welt; Vektoren- Politische und kritische Potentiale relationaler Philologie; Arquipel I- Occidentes-Orientes; ZeitRäume-Vom Lebenswissen der Literaturen der Welt e Archipel II- America(s) transareal. Nos diferentes capítulos Ette traça linhas que partem de uma abordagem dos métodos dos estudos filológicos e da comparação entre os conceitos: Literatura universal e Literaturas do mundo. O conceito Literaturas do mundo contrasta com o conceito histórico de Goethe (Weltliteratur), sendo algo novo, pois abrange diferentes lógicas de escrita e de interpretação. Em WeltFraktale: Wege durch die Literaturen der Welt, Ottmar Ette ilustra os estudos filológicos pelas múltiplas perspectivas e lógicas, considerando movimentos de transárea nas Literaturas do mundo. O textos passam a ser investigados em pensamentos arquipélagos complexos, tendo na obra de arte, na lírica e na prosa, exemplos de fractais que se completam em sua significação e sentido e “nesse fractal do mundo se representa um mundo inteiro” (ETTE, 2019).
Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors
Authors: Midha Ayush , Pan Hui , Abarca Cristian , Andle Joshua , Carapeto Priscila , Bonner-Weir Susan , Aguayo-Mazzucato Cristina 
Published: March 2021

The aging of pancreatic β-cells may undermine their ability to compensate for insulin resistance, leading to the development of type 2 diabetes (T2D). Aging β-cells acquire markers of cellular senescence and develop a senescence-associated secretory phenotype (SASP) that can lead to senescence and dysfunction of neighboring cells through paracrine actions, contributing to β-cell failure. In this study, we defined the β-cell SASP signature based on unbiased proteomic analysis of conditioned media of cells obtained from mouse and human senescent β-cells and a chemically induced mouse model of DNA damage capable of inducing SASP. These experiments revealed that the β-cell SASP is enriched for factors associated with inflammation, cellular stress response, and extracellular matrix remodeling across species. Multiple SASP factors were transcriptionally upregulated in models of β-cell senescence, aging, insulin resistance, and T2D. Single-cell transcriptomic analysis of islets from an in vivo mouse model of reversible insulin resistance indicated unique and partly reversible changes in β-cell subpopulations associated with senescence. Collectively, these results demonstrate the unique secretory profile of senescent β-cells and its potential implication in health and disease.
Carmen María Pujante Segura: La novela corta contemporánea (desde mediados del siglo XX hasta hoy a través de Ayala, Vila-Matas y Barba). Madrid: Visor, 2019.
Authors: Mendoza Vera Sandra 
Published: March 2021

Reseña de Carmen María Pujante Segura: La novela corta contemporánea (desde mediados del siglo XX hasta hoy a través de Ayala, Vila-Matas y Barba). Madrid: Visor, 2019.
Historiosophy of N.Ya. Danilevsky
Authors: Aksyuchits Victor V. 
Published: March 2021

According to the author of the article, N.Ya. Danilevsky anticipated a lot of ideas of the 20th century, in particular those of O. Spengler and A. Toynbee, by offering his concept of cultural and historical types in the book “Russia and Europe”. At the same time N.Ya. Danilevsky was in many aspects the follower of Slavophils while interpreting the originality of Russian people and Russian culture. After the turn of the educated society circles to Russian national self-comprehension initiated by Slavophils, N.Ya. Danilevsky not only scientifically formulated the problems brought forth by the Slavophils, but also offered for the first time the resolution of new important questions by analyzing the world history and the history of Slavic peoples. The author especially stresses the role of N.Ya. Danilevsky in creating the historiosophic concept that forestalled the epoch for many decades.