bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTS OF EXERCISE WITH MUSIC IN FRAIL OLDER ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Kim Namhee , Kim Gwang Suk , Park Min Kyung , Kim Layoung , Lee Jae Jun 
Published: January 2025

Abstract
Accumulating research on the impact of exercise with music on the health of frail older adults emphasized the necessity of a comprehensive analysis that encompasses physical and emotional health outcomes. Consequently, this study aimed to identify the contents and characteristics of exercising with music and to evaluate the effects of exercising with music on the physical and emotional health of frail community-dwelling older adults. This was a systematic literature review and a meta-analysis. All searches were conducted from April 12, 2022, to March 2, 2024, with no restrictions on language or publication date. Seven electronic databases were searched: MEDLINE, CINAHL, Embase, Cochrane Library, PsyINFO, Google Scholar, and the Virginia Henderson International Nursing Library. PRISMA guidelines for systematic reviews were followed. After screening the initial 1409 studies, 17 studies, including 13 randomized controlled trials and four quasi-experimental studies, were analyzed. The findings indicate that exercise with music has positive effects on reducing frailty (SMD = -0.43, 95% CI = -0.81 – -0.05), improving Timed Up and Go test results (MD = -3.76, 95% CI = -6.67 – -0.85), increasing handgrip strength (MD = 2.01, 95% CI = 0.36 – 3.65), and decreasing depression levels (SMD = -0.34, 95% CI = -0.56 – -0.11) among frail older adults. By addressing both physical and emotional health, exercise with music can significantly contribute to enhancing older adults’ quality of life and reducing the burden of frailty. In conclusion, this review emphasizes musical exercises’ potential as a multifaceted intervention for frail older adults.
EXPLORING THE RELATIONSHIP BETWEEN MULTIDOMAINS OF FRAILTY AND MORTALITY IN OLDER ADULTS LIVING IN COMMUNITY
Authors: Li Yuelin , Song Rhayun , Seo Jisu 
Published: January 2025

Abstract
The global population’s aging presents health challenges. This study aimed to explore the relationship between various domains of frailty (physical, cognitive, social, and multidimensional) on all-cause mortality in community-dwelling older adults. Studies were searched in five databases up to December 5, 2023. Quality and Risk of Bias assessment were assessed using the ROBINS-E tool. A meta-analysis was performed to synthesize pooled mortality risk estimates by using the random-effects model. A total of 53 studies were included for systematic review, with 49 eligible for meta-analysis, involving 153,237 participants and over 31,021 deaths. The quality assessment revealed that 10 were low risk (18.9%), 7 had some concerns (13.2%), 34 were high risk (64.2%), and 2 were considered very high risk (3.7%). Results indicated that frail older adults had a significantly higher mortality risk than robust ones, consistent across frailty domains (physical HR=1.72, 95 CI%:1.50-1.97; social HR=1.17, 95 CI%:1.04-1.31; multidimensional HR=2.37, 95 CI%: 2.10-2.68; cognitive HR=1.48, 95 CI%:1.09-2.01). Our findings highlight that various domains of frailty are strongly and robustly associated with all-cause mortality in older adults. This relationship between multidimensional frailty and mortality is stronger than that of a single type of frailty. Therefore, although focusing on a single frailty can improve the well-being of the older population, interventions targeting multiple aspects of frailty are more effective in improving the quality of life and longevity of this population.
JOINT TRAJECTORIES OF FRAILTY AND COGNITIVE FUNCTION IN OLDER KOREANS: A 14-YEAR ANALYSIS WITH NATIONAL-LEVEL DATA
Authors: Jung Yunkyung , Lyu Jiyoung 
Published: January 2025

Abstract
Despite the evidence on the link between frailty and cognitive function, less is known about the joint developments of these two multidimensional indexes. The present study aimed to identify distinct trajectories of frailty and cognitive function and examine the influence of sociodemographic and lifestyle factors on the co-development of frailty and cognitive function in older Koreans. A nationally representative sample of 2,766 adults aged ≥65 years from the first (2006) to the eighth (2020) waves of the Korean Longitudinal Study of Aging (KLoSA) was analyzed. Frailty was measured with a Frailty Index with 33 deficit-related indicators. Cognitive function was measured using the Mini-Mental State Examination (MMSE). Group-based trajectory modeling was used to fit the developments of frailty and cognitive function. A multinomial logistic regression was conducted to assess the predictors for each trajectory group. Three joint trajectories were identified, including cognitive frailty (13.2%), cognitive decline and progressive frailty (33.0%), and no cognitive frailty (53.7%). Compared to individuals in the no cognitive frailty group, those in the cognitive frailty group were more likely to be unemployed and current smokers; while those in the cognitive decline and progressive frailty group were more likely to be women, have low income, and not current drinkers. Significant heterogeneity in the co-development of frailty and cognitive function in older Koreans was identified. Findings suggest that different sociodemographic and lifestyle factors determined the trajectory membership.
PLASMA PROTEOMIC SIGNATURE OF DEVELOPMENT AND PROGNOSIS OF PHYSICAL FRAILTY
Authors: Xu Jianhong , Liu jingyun , Liao Jinhui , Wu Chenkai 
Published: January 2025

Abstract
The complete understanding of biological mechanisms behind frailty remains elusive. We aimed to investigate the proteomic signature associated with the development and prognosis of frailty. Data from 43,895 participants (aged 39-70 years) in the UK Biobank were analyzed, with 2,920 proteins assayed using Olink. Participants were split into development and validation cohorts based on geographic location. Multinomial logistic models identified proteins cross-sectionally associated with baseline prefrailty and frailty (Bonferroni-corrected p-value &lt; 0.05). Cox models identified proteins associated with mortality among initially prefrail and frail participants. LASSO regression was used to construct protein-based prediction models for death among prefrail and frail participants, respectively. Protein importance was ranked using the light gradient boosting machine classifier. We identified 210 and 268 proteins cross-sectionally associated with prefrailty and frailty at baseline, respectively. Additionally, 109 and 80 proteins were associated with mortality among initially prefrail and frail individuals, respectively. LASSO regression model selected 60 and 21 proteins predicting survival in prefrail and frail participants, respectively. Protein-based prediction models demonstrated satisfactory discrimination, calibration, and reclassification in the development and validation cohorts. GDF15 (WFDC2) and PLAUR emerged as the top two proteins in prefrailty (frailty) development, demonstrating robust connections with overall survival in prefrail (frail) individuals. Differentially expressed proteins were enriched in pathways involving protein metabolism, cellular signaling in disease, apoptosis, and inflammation. Exploring novel proteins and pathways provides insights into the biological mechanisms and potential therapeutic targets associated with the onset and progression of frailty.
TOWARD DEVELOPING PATIENT-ORIENTED WEBSITES FOR EARLY DETECTION AND MANAGEMENT OF FRAILTY
Authors: Chung Seohyeon , Song Xiaowei 
Published: January 2025

Abstract
Understanding frailty status of older adults before a doctor’s visit can result in more effective care planning, where web technology can play role. We conducted a study engaging community-dwelling older adults and caregivers to better understand their perspectives about developing patient-oriented frailty websites. Our objectives are to describe the project activities and share the insights learned from potential end-users of the website. We first organized an online educational symposium consisting of six invited talks on patient-oriented frailty management given by experts of frailty and older adult care. Audience of the symposium was recruited through newsletters and academic, community, and patient association platforms. Clinicians, researchers, caregivers, and community-dwelling older adults across Canada participated (n=300). Members from the symposium (n=14) participated in two virtual discussion sessions with open-ended questions. Discussions highlighted aspects, including the function, usage, and feasibility of a frailty website; security and privacy of online health data; patient-physician interactions; and existing technologies and resources supporting patient-oriented frailty management for successful aging in place. Our findings revealed the needs, barriers, and possible solutions with developing patient-oriented frailty websites. The effort towards building frailty websites that patients can use will benefit future development and implementation to identify people at risk of frailty and facilitate real-time monitoring for personalized and preventative care.
REGIONAL POLICY SCAN: POLICIES TO ADDRESS AGING IN SUB-SAHARAN AFRICA
Authors: Osae-Oppong Edward 
Published: January 2025

Abstract
This paper presenting a regional policy scan focused on aging in sub-Saharan Africa. The study aims to provide an overview of policy responses to aging in the region, identifying key challenges, opportunities, and recommendations for addressing the needs of the aging population. The methodology involves conducting a critical essay reviewing articles on public policy related to mental health and well-being in older populations across databases such as PubMed, Google Scholar, and Science Direct. This review analyzes policies addressing healthcare needs and identifies demographic, economic, and social trends to understand the aging population comprehensively. Findings from the policy scan reveal a growing aging population in sub-Saharan Africa, with existing policies and strategies in place to address their needs. However, challenges persist in implementing effective policies, social protection systems, and engaging the private sector. Key recommendations include advocating for a comprehensive and coordinated approach to aging, improving access to healthcare and social services, incentivizing employers to hire older workers, and increasing public awareness of aging issues. The study concludes that sub-Saharan Africa faces significant challenges and opportunities concerning its aging population. It underscores the importance of developing and implementing effective policies and strategies to address the healthcare needs of older populations, strengthen social protection systems, and engage the private sector. By investing in the health and well-being of older adults, sub-Saharan Africa can achieve sustainable economic development and enhance the quality of life for its aging population.
THE ICHANGE PROJECT: AN HRSA SPNS INITIATIVE TO ADVANCE HIV AND AGING CARE
Authors: Burk-Leaver Erin , Sanner Haley , Saenz Janette Romero , Abraham Alison , Erlandson Kristine M 
Published: January 2025

Abstract
With the advent of antiretroviral therapy (ART), improvements in life expectancy of people living with HIV (PLWH) are now nearing that of populations living without HIV. As a result, over 50% of PLWH within the United States – over 55% in Colorado – are now aged 50 years and older. While this shift highlights how ART has drastically improved the life expectancy of PLWH, aging with HIV is associated with unique issues and challenges that impact quality of life. In response to these challenges, the Health Resources and Services Administration (HRSA) Ryan White HIV/AIDS Program (RWHAP) Part F: Special Projects of National Significance (SPNS) funded the design, implementation, and evaluation of emerging strategies to improve the well-being of people with HIV ages 50 and older served by RWHAP. Colorado Health Network (CHN), serving as one of ten national demonstration sites under the HRSA SPNS HIV and Aging Initiative, developed the iCHANGE (Integrative Care for Healthy Aging and Navigation of Geriatric Effects) Project, an integrated healthcare model designed to comprehensively assess comorbidities and geriatric conditions among older PLWH, with the overarching goal of improving health outcomes. Drawing on concepts such as the Public Health Prevention model, Geriatric 5M’s framework, and implementation science methodology, CHN’s iCHANGE strategy enhances the ongoing efforts to develop holistic healthcare programs to support and navigate the unique challenges faced by older PLWH. This presentation aims to provide insight and a comprehensive overview into the evolving landscape of supportive healthcare delivery for people living and aging with HIV.
NURSING FACILITY RESPONSES TO GROWING CONSUMER COMPLAINTS
Authors: Applebaum Robert , Bowblis John , Nelson Matt , Dikhtyar Oksana 
Published: January 2025

Abstract
Nursing home consumers can file a complaint to regulators regarding such areas as quality of care or resident rights. The number of formal complaints filed has increased at dramatically. Between 2016 and 2021, Ohio saw a 40% increase in the number of complaints. A number of factors are associated with complaints including staffing levels and staff and leadership turnover. The increase in complaints is an indicator that residents and families do not feel satisfied with their nursing home experience, and it is also a huge strain on the nursing home inspection process. Last year in Ohio fewer than 40% of required nursing home recertification surveys were completed in the required window. The critical question then becomes, are there things that can be done by facilities to reduce the number of complaints filed with regulators. Using data from the 2023 Biennial Survey of Long-Term Care Facilities completed in Ohio on all licensed nursing homes, this paper examines the strategies used by nursing homes to respond to the growing number of complaints. Approaches examined include such areas as having a dedicated staff member to examine complaints or building a review of complaints into the facility quality improvement process. The survey also presents findings about the interactions with the Department of Health survey teams. Data suggest there is a long lag between a complaint visit and an adjudication of the complaint. The paper concludes with recommendations for facilities and states as they respond to the growing number of complaints experienced across the nation.
RELATED FACILITY AND RESIDENT FACTORS ON STANDARDIZED NURSING LANGUAGES FOR NURSING HOME NURSES IN KOREA
Authors: shin Juh Hyun , Park Chung Hyuk , Lee Myungeun , Park Suhyun 
Published: January 2025

Abstract
Standardized nursing languages play a crucial role in facilitating holistic nursing care, but their full benefits are still being realized. However, the implementation of NNN linkages and their impact on nursing processes and nursing home (NH) residents’ outcomes, as well as the identification of facility and resident factors, remain unexplored. The purpose of this study was to examine (a) frequently occurring NNN linkages and (b) related facility and resident factors on the use of NANDA, NIC, and NOC for NH residents. Data were collected from 273 residents in 19 NHs in Korea 19 NHs in Korea, with structured questionnaires administered to NH registered nurses using a newly developed smartphone application. Descriptive statistics, ANOVA, and ANCOVA were used for the data analysis. We identified that factors, such as case mix index (resident acuity), age of resident, year of facility establishment, facility ownership status, and admission period of residents, are related to the use of NANDA, NIC, and NOC. Nine NNN linkages were newly identified in this study, mostly centered on fall prevention. The findings provide various approaches to address the risk of falls in NHs considering environmental, physical, and psychological factors. This study contributes to the foundation of evidence related to NHs by collecting specific data on the nursing process for the physiological, behavioral, safety, family, health system, and community areas applied to the residents of long-term care facilities at the national level. Future research in different settings and tailored population is needed.
EXPLORING ASSISTIVE TECHNOLOGY ACCESS AND USE AMONG OLDER ADULTS THROUGH SELF-DIRECTED HOME TOURS
Authors: Mortenson Ben , Tsai Chih-TIng (Gina) , Yu Chin Wing , Huot Suzanne , Hurd Laura 
Published: January 2025

Abstract
Assistive technology (AT) and home modifications play a crucial role in enhancing independence and quality of life for individuals with disabilities. Our aim was to explore access and use of AT for older adults through an innovative research methodology, virtual self-directed home tours. These interviews were held across three groups of participants (A) first-generation Chinese-speaking immigrants to Canada, (B) second and subsequent generations of Chinese-speaking immigrants, and (C) native-born English-speaking Canadian citizens of European descent. A total of 17 interviews were conducted (Group A=8, Group B=3, and Group C=6) through Zoom Video Communications. Participants were demographically diverse adults with disabilities living in Metro Vancouver, British Columbia (Age= 59 ± 15 years; 11 female and 6 male). Most participants had assistance from their caregivers to complete the interview. Three main themes were identified. (1) Enabling Participation described the transformative role of AT in optimizing participants’ ability to engage in activities that are meaningful to them independently. (2) User-Driven Do-It-Yourself Adaptations explored how participants developed cost effective alternatives by creatively adding their own modifications to existing AT. (3) Navigating Complexities and Hurdles encompassed the challenges with accessing and incorporating AT in their homes due to lack of adequate knowledge transfer from healthcare professionals, financial circumstances, and other systemic barriers that further delayed the implementation of home modifications. Chinese-speaking immigrants faced compound challenges due to language barriers. The insights gained from this study may inform strategies for improving the experiences of older adults accessing and using AT and home modifications.
LIFE SPACE MOBILITY IS ASSOCIATED WITH DISTINCT FACTORS BELOW AND ABOVE THE AGE OF 75 YEARS
Authors: Khalil Samar Assadi , Kizony Rachel , Gil Efrat , Tzemah-Shahar Roy , Agmon Maayan 
Published: January 2025

Abstract
Life-space mobility (LSM) is associated with the quality of life and well-being of older adults, and it is influenced by individual and environmental factors. However, age-related differences are ignored. This study aimed to explore which factors are associated with LSM in community-dwelling older adults from two age groups (&lt; 75 and≥75 years). This cross-sectional study included older adults aged 65 and over, independently mobile, without neurologic conditions or dementia. LSM, the dependent variable, was assessed using the Life-Space Assessment-(LSA). Independent variables were assessed using Timed Up and Go-(TUG) for mobility, Montreal Cognitive Assessment-(MoCA) for cognition, Activities-specific Balance Confidence Scale-(ABC) for fear of falling, Hospital Anxiety and Depression Scale-(HADS) for depression, and four-functional mobility tasks for participation. Additionally, functional status and number of medications were assessed. Two separate stepwise regression models were conducted for older adults aged&lt; 75 and≥75 years. Two-hundred forty-two older adults (28.9% men) were included [mean(SD) age: 73.7(6.4) years], of whom 40.9% were≥75 years. Results revealed that different factors were associated with LSM in each age group. For those&lt; 75 years, participation and TUG explained 33% and 9.4% of the variance in LSM, respectively. Conversely, for the older group, ABC, MoCA, and TUG explained 33.5%, 4.1% and 5.2% of the variance in LSM, respectively. Our finding shows that distinct factors are associated with LSM in each group, particularly mobility in the younger and fear of falling in the older. By highlighting these specific factors, interventions can be tailored more effectively to enhance the quality of life and well-being of older adults.
LONGEVITY POLYGENIC RISK IN MULTIDOMAIN AGING AND LONG-TERM SURVIVAL AMONG OLDER WHITE AND BLACK ADULTS
Authors: Chen Siting , Nagel Corey L , Lapidus Jodi , Quiñones Ana 
Published: January 2025

Abstract
This study aims to identify genetic characteristics of multi-dimensional aging and longevity by examining the association of longevity polygenic risk scores with multi-domain aging trajectories and long-term survival in older Non-Hispanic White and Non-Hispanic Black adults. We studied 7,287 older adults (≥ 65 years, 14.0% Non-Hispanic Black) from the Health and Retirement Study (HRS, 1998-2016). Group-based trajectory modeling was performed to identify distinct groups of older adults following similar joint trajectories of aging across four domains (multimorbidity burden, functional status, cognitive performance, and depressive symptomatology). We identified four distinct multi-domain trajectory groups: minimal impairment with low multimorbidity (34.1%), minimal impairment with high multimorbidity (37.1%), multidomain impairment with intermediate multimorbidity (16.7%), and multidomain impairment with high multimorbidity (12.1%). Longevity polygenic risk scores (categorized as low, medium, medium-high, and high) were compared between long-term survival groups (long-lived group and controls) across the identified trajectory groups in Non-Hispanic White and Black adults. The proportion of long-lived group was significantly higher in minimal impairment with low multimorbidity group in both Non-Hispanic White (23.3%,p&lt; 0.01) and Non-Hispanic Black adults (19.6%,p&lt; 0.01). The long-lived group had greater proportions of Non-Hispanic White participants with high longevity polygenic risk scores in all trajectory groups. The long-lived group had lower proportions of Non-Hispanic Black participants with low longevity polygenic risk scores in all trajectory groups except for the multi-domain impairment with high multimorbidity group. Our study highlights the need to examine the constellation of genetic and socioeconomic factors on aging-related health domains and longevity among diverse groups of older adults.