bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Protective Effect of Dexmedetomidine Against Ischemia-Reperfusion Injury after Hepatectomy: A Meta-Analysis of Randomized Controlled Trials
Authors: Huang Ya-Qun , Wen Rui-Ting , Li Xiao-Tong , Zhang Jiao , Yu Zhi-Ying , Feng Yu-Fei 
Published: October 2021

Background: Hepatic inflow occlusion proceeded to reduce blood loss during hepatectomy induces ischemia-reperfusion (IR) injury in the remnant liver. Dexmedetomidine, a selective α2-adrenoceptor agonist used as an anesthetic adjuvant, has been shown to attenuate IR injury in preclinical and clinical studies. However, a meta-analysis is needed to systematically evaluate the protective effect of perioperative dexmedetomidine use on IR injury induced by hepatectomy.Methods: A prospectively registered meta-analysis following Cochrane and PRISMA guidelines concerning perioperative dexmedetomidine use on IR injury after hepatectomy was performed via searching Cochrane Library, PubMed, EMBASE, ClinicalTrials.gov, Web of Science, CNKI, WanFang, and Sinomed for eligible randomized controlled trials up to 2021.3.31. The main outcome is postoperative liver function. Risk of bias was assessed by the Cochrane Risk of Bias tool. Review Manager 5.3 and Stata12.0 were applied to perform data analyses.Results: Eight RCTs enrolling 468 participants were included. Compared with 0.9% sodium chloride, dexmedetomidine decreased serum concentration of ALT (WMD = −66.54, 95% CI: −92.10–−40.98), AST (WMD= −82.96, 95% CI: −106.74–−59.17), TBIL (WMD = −4.51, 95% CI: −7.32–−1.71), MDA (WMD = −3.09, 95% CI: −5.17–−1.01), TNF-α (WMD = −36.54, 95% CI: −61.33–−11.95) and IL-6 (WMD = −165.05, 95% CI: −225.76–−104.34), increased SOD activity (WMD = 24.70, 95% CI: 18.09–31.30) within postoperative one day. There was no significant difference in intraoperative or postoperative recovery parameters between groups.Conclusions: Perioperative administration of dexmedetomidine can exert a protective effect on liver IR injury after hepatectomy. Additional studies are needed to further evaluate postoperative recovery outcomes of dexmedetomidine with different dosing regimens.
Comprehensive Analysis of Inflammatory Response–Related Genes, and Prognosis and Immune Infiltration in Patients With Low-Grade Glioma
Authors: Han Tao , Zuo Zhifan , Qu Meilin , Zhou Yinghui , Li Qing , Wang Hongjin 
Published: October 2021

Background: Although low-grade glioma (LGG) has a good prognosis, it is prone to malignant transformation into high-grade glioma. It has been confirmed that the characteristics of inflammatory factors and immune microenvironment are closely related to the occurrence and development of tumors. It is necessary to clarify the role of inflammatory genes and immune infiltration in LGG.Methods: We downloaded the transcriptome gene expression data and corresponding clinical data of LGG patients from the TCGA and GTEX databases to screen prognosis-related differentially expressed inflammatory genes with the difference analysis and single-factor Cox regression analysis. The prognostic risk model was constructed by LASSO Cox regression analysis, which enables us to compare the overall survival rate of high- and low-risk groups in the model by Kaplan–Meier analysis and subsequently draw the risk curve and survival status diagram. We analyzed the accuracy of the prediction model via ROC curves and performed GSEA enrichment analysis. The ssGSEA algorithm was used to calculate the score of immune cell infiltration and the activity of immune-related pathways. The CellMiner database was used to study drug sensitivity.Results: In this study, 3 genes (CALCRL, MMP14, and SELL) were selected from 9 prognosis-related differential inflammation genes through LASSO Cox regression analysis to construct a prognostic risk model. Further analysis showed that the risk score was negatively correlated with the prognosis, and the ROC curve showed that the accuracy of the model was better. The age, grade, and risk score can be used as independent prognostic factors (p &lt; 0.001). GSEA analysis confirmed that 6 immune-related pathways were enriched in the high-risk group. We found that the degree of infiltration of 12 immune cell subpopulations and the scores of 13 immune functions and pathways in the high-risk group were significantly increased by applying the ssGSEA method (p &lt; 0.05). Finally, we explored the relationship between the genes in the model and the susceptibility of drugs.Conclusion: This study analyzed the correlation between the inflammation-related risk model and the immune microenvironment. It is expected to provide a reference for the screening of LGG prognostic markers and the evaluation of immune response.
Differences in the Anthropometric and Physiological Profiles of Hungarian Male Rowers of Various Age Categories, Rankings and Career Lengths: Selection Problems
Authors: Alfőldi Zoltan , Borysławski Krzysztof , Ihasz Ferenc , Soós Imre , Podstawski Robert 
Published: October 2021

Background: Little is known about the anthropometric and physiological profiles of lower-ranking athletes who aspire to rise to the pinnacle of their profession.Aim: The aim of this study was to create anthropometric and physiological profiles of Hungarian male rowers of different age categories (15–16, 17–18, and over 18 years), sports rankings and career lengths.Materials and Methods: Anthropometric and physiological profiles were created for 55 juniors, 52 older juniors and 23 seniors representing seven of the largest Hungarian rowing clubs. One-way independent analysis of variance (ANOVA) was used to compare arithmetic means.Results: Rowers in older age categories were significantly taller (185.0 ± 5.0 cm vs. 183.0 ± 7.3 cm vs. 178.7 ± 7.2 cm) and heavier (81.1 ± 8.8 kg vs. 73.7 ± 8.4 kg vs. 66.8 ± 12.3 kg) than their younger peers, with significantly higher BMI values and larger body dimensions. Compared to younger athletes, rowers in older age categories also covered 2,000 m significantly faster (6.6 ± 0.3 min vs. 6.9 ± 0.4 min vs. 7.5 ± 0.5 min) while developing significantly more power (372.2 ± 53.0 W vs. 326.8 ± 54.5 W vs. 250.6 ± 44.6 W). Similarly, seniors and older juniors had higher values of maximal oxygen uptake and force max (by 6.2 and 7.0 ml/kg/min, and by 263.4 and 169.8 N). Within the older juniors, internationally ranked rowers had significantly greater body height (+ 5.9 cm), body mass (+ 6.1 kg), sitting height (+ 2.7 cm), arm span (+ 7.9 cm), limb length (+ 3.73 cm) and body surface area (+ 0.21 m2). They also rowed 2,000 m significantly faster (–0.43 min, p &lt; 0.001) and had significantly higher values of power (+ 58.3 W), relative power (+ 0.41 W/kg), jump height (+ 4.5 cm), speed max (+ 0.18 m/s) and force max (+ 163.22 N).Conclusion: The study demonstrated that potential differences in anthropometric and physiological profiles are more difficult to capture in non-elite rowers, and that the final outcome may be determined by external factors. Therefore, athletes with superior aptitude for rowing are more difficult to select from among lower-ranking rowers, and further research is needed to determine specific training requirements to achieve the maximum rowing performance.
Measuring Food-Related Attentional Bias
Authors: Franja Stefania , McCrae Anna E. , Jahnel Tina , Gearhardt Ashley N. , Ferguson Stuart G. 
Published: October 2021

Objective: Food-related attentional bias has been defined as the tendency to give preferential attention to food-related stimuli. Attentional bias is of interest as studies have found that increased attentional bias is associated with obesity; others, however, have not. A possible reason for mixed results may be that there is no agreed upon measure of attentional bias: studies differ in both measurement and scoring of attentional bias. Additionally, little is known about the stability of attentional bias over time. The present study aims to compare attentional bias measures generated from commonly used attentional bias tasks and scoring protocols, and to test re-test reliability.Methods: As part of a larger study, 69 participants (67% female) completed two food-related visual probe tasks at baseline: lexical (words as stimuli), and pictorial (pictures as stimuli). Reaction time bias scores (attentional bias scores) for each task were calculated in three different ways: by subtracting the reaction times for the trials where probes replaced (1) neutral stimuli from the trials where the probes replaced all food stimuli, (2) neutral stimuli from the trials where probes replaced high caloric food stimuli, and (3) neutral stimuli from low caloric food stimuli. This resulted in three separate attentional bias scores for each task. These reaction time results were then correlated. The pictorial visual probe task was administered a second time 14-days later to assess test-retest reliability.Results: Regardless of the scoring use, lexical attentional bias scores were minimal, suggesting minimal attentional bias. Pictorial task attentional bias scores were larger, suggesting greater attentional bias. The correlation between the various scores was relatively small (r = 0.13–0.20). Similarly, test-retest reliability for the pictorial task was poor regardless of how the test was scored (r = 0.20–0.41).Conclusion: These results suggest that at least some of the variation in findings across attentional bias studies could be due to differences in the way that attentional bias is measured. Future research may benefit from either combining eye-tracking measurements in addition to reaction times.
Second Graders’ Grapho-Motor Skill Learning and Verbal Learning: The Effects of Socio-Educational Factors
Authors: Hollander Chagit , Adi-Japha Esther 
Published: October 2021

Introduction: Children from low socioeconomic status (SES) families, and in particular, those with a lower level of maternal education, show lower fine-motor skills and lower vocabulary scores than their SES peers whose mothers have a higher level of education. Furthermore, low SES children frequently have difficulties in reading and spelling. These difficulties are attributed to deficits in the acquisition of skills through practice, such as those required for developing visual-motor routines, alongside deficits in the intentional acquisition of knowledge, such as those required in verbal learning. The aim of the current study was to test the effect of two background factors: low maternal education (ME) and risk of reading and spelling difficulties on practice-dependent learning of a motor task and intentional learning of a verbal task in second graders from low SES families.Methods: In 2016/17, 134 low-SES second graders with higher and lower ME (95 typical learners and 39 with reading and spelling difficulties) were assessed with (a) the Invented Letter Task (ILT; a grapho-motor skill learning task) across five time-points (initial- and end-training Day 1; initial- and end-training Day 2; and 2-weeks post-training), as well as an ILT transfer task; and (b) The Rey Auditory Verbal Learning Test (RAVLT; an intentional word-learning task in which a word list is read to children for five learning trials and is recalled 20 min later).Findings: Lower ME was associated with surplus segments in the performance of the motor task and its transfer to a novel condition as well as with lower recall on the verbal task, but not with the learning of both the motor and the verbal task. Having reading and spelling difficulties affected motor-task accuracy and also the way children learned the task, as evidenced by surplus segments at the beginning of Day 2, which were reduced with further practice.Conclusion: Low ME affected overall performance level. Reading and spelling difficulties resulted in atypical learning of the motor task. Future research on practice-dependent learning in the context of children coming from low SES families should focus on subgroups within this heterogeneous population.
Investigating the Persuasive Effects of Testimonials on the Acceptance of Digital Stress Management Trainings Among University Students and Underlying Mechanisms: A Randomized Controlled Trial
Authors: Apolinário-Hagen Jennifer , Fritsche Lara , Wopperer Jeannette , Wals Frank , Harrer Mathias , Lehr Dirk , Ebert David D. , Salewski Christel 
Published: October 2021

Objective: This experiment aims to investigate the influence of narrative information varying in the degree of perceived similarity and source credibility in supplemented testimonials on the acceptance of digital mental health services (digi-MHSs).Methods: In fall 2020, n=231 university students were randomly assigned to an active control group (aCG, n=55, “information only”) or one of three intervention groups (IGs) receiving information plus different testimonials being presented either by nonacademic staff (IG1, n=60), university students (IG2, n=58) or experts (IG3, n=58). We assessed mediation effects of similarity and credibility on acceptance in terms of attitudes and usage intentions.Results: Exposure to testimonials was associated with higher usage intentions (d=0.50) and more positive attitudes toward digi-MHSs (d=0.32) compared to mere information (aCG). Regarding source-related effects, one-way ANOVA showed group differences in intentions (ηp2=0.13) that were significantly higher after exposure to testimonials targeted at students than in the other groups after adjusting for baseline intentions (ηp2=0.24). Concerning underlying mechanisms, there were full mediation effects of similarity (IG1 versus IG2) on attitudes [95%CI (0.030, 0.441)] and intentions to use digi-MHSs [95%CI (0.100, 0.528)] and of credibility on attitudes [IG2 versus IG3; 95%CI (−0.217, −0.004)], all favoring students’ testimonials.Conclusion: Overall, this study indicates that the acceptance of digi-MHSs can be substantially increased by providing a simple, context-sensitive information intervention, including testimonials by university students. Since we identified mediating effects of credibility on cognitive attitudes and similarity on affect-driven intentions, a future trial could vary these features using narrative versus statistic information on digi-MHSs.
Altered Fractional Amplitude of Low-Frequency Fluctuation in Major Depressive Disorder and Bipolar Disorder
Authors: Qiu Yan , Yang Min , Li Sujuan , Teng Ziwei , Jin Kun , Wu Chujun , Xu Xuelei , Chen Jindong , Tang Hui , Huang Jing , Xiang Hui , Guo Wenbin , Wang Bolun , Wu Haishan 
Published: October 2021

Background: Discriminating between major depressive disorder (MDD) and bipolar disorder (BD) remains challenging and cognitive deficits in MDD and BD are generally recognized. In this study, the fractional amplitude of low-frequency fluctuation (fALFF) approach was performed to explore neural activity and cognition in first-episode, drug-naïve BD and MDD patients, as well as the relationship between altered fALFF values and clinical or psychometric variables.Methods: A total of 21 BD patients, 25 MDD patients, and 41 healthy controls (HCs) completed clinical assessments and resting-state functional magnetic resonance imaging (rs-fMRI) scans in this study. The rs-fMRI data were analyzed by fALFF method and Pearson correlation analyses were performed between altered fALFF values and clinical variables or cognition. Support vector machine (SVM) was adopted to identify the three groups from each other with abnormal fALFF values in the brain regions obtained by group comparisons.Results: (1) The fALFF values were significantly different in the frontal lobe, temporal lobe, and left precuneus among three groups. In comparison to HCs, BD showed increased fALFF values in the right inferior temporal gyrus (ITG) and decreased fALFF values in the right middle temporal gyrus, while MDD showed decreased fALFF values in the right cerebellar lobule IV/V. In comparison to MDD, BD showed decreased fALFF values in bilateral posterior cingulate gyrus and the right cerebellar lobule VIII/IX. (2) In the BD group, a negative correlation was found between increased fALFF values in the right ITG and years of education, and a positive correlation was found between decreased fALFF values in the right cerebellar lobule VIII/IX and visuospatial abilities. (3) The fALFF values in the right cerebellar lobule VIII/IX may have the ability to discriminate BD patients from MDD patients, with sensitivity, specificity, and accuracy all over 0.70.Conclusions: Abnormal brain activities were observed in BD and MDD and were related with cognition in BD patients. The abnormality in the cerebellum can be potentially used to identify BD from MDD patients.
The Relationship Between Gambling Problems and the Five-Factor Model of Personality: A Systematic Review and Meta-Analysis
Authors: Strømme Rune , Børstad Karine Holthe , Rø Andrea Eftang , Erevik Eilin Kristine , Sagoe Dominic , Chegeni Razieh , Aune Mentzoni Rune , Kaur Puneet , Pallesen Ståle 
Published: October 2021

Objectives: The aim of the present meta-analysis was to synthesize results from the association between problem gambling (PG) and dimensions of the five factor model of personality and to identify potential moderators (gambling diagnosis: yes/no, comorbidity: yes/no and trait assessment: four or fewer items vs. five items or more) of these associations in meta-regressions.Methods: Searches were conducted in six databases; Medline, Web of Science, PsychInfo, Google Scholar, OpenGrey, and Cochrane Library (conducted on February, 22, 2021). Included studies: (1) reported a relationship between PG and at least one of the personality traits in the five-factor model, (2) contained information of zero-order correlations or sufficient data for such calculations, and (3) were original articles published in any European language. Case-studies, qualitative studies, and reviews were excluded. All articles were independently screened by two authors. Final agreement was reached through discussion or by consulting a third author. Risk of bias of the included studies was assessed by the Newcastle-Ottawa Scale. Data were synthesized using a random effects model.Results: In total 28 studies, comprising 20,587 participants, were included. The correlations between PG and the traits were as follows: Neuroticism: 0.273 (95% CI = 0.182, 0.358), conscientiousness −0.296 (95% CI = −0.400, −0.185), agreeableness −0.163 (95% CI = −0.223, −0.101), openness −0.219 (95% CI = −0.308, −0.127), and extroversion −0.083 (95% CI = −0.120, −0.046). For all meta-analyses the between study heterogeneity was significant. Presence of gambling diagnosis was the only moderator that significantly explained between-study variance showing a more negative correlation to extroversion when participants had a gambling diagnosis compared to when this was not the case.Discussion: The results indicated some publication bias. Correcting for this by a trim-and-fill procedure showed however that the findings were consistent. Clinicians and researchers should be aware of the associations between personality traits and PG. Previous studies have for example showed neuroticism to be related to treatment relapse, low scores on conscientiousness to predict treatment drop-out and agreeableness to reduce risk of treatment drop-out.Systematic Review Registration: PROSPERO (CRD42021237225).
Sociodemographic Indicators of Child and Adolescent Mortality in Finland—A Nationwide Study of 310 Municipalities Covering Over 5,000,000 Inhabitants
Authors: Oura Petteri , Sajantila Antti 
Published: October 2021

Background: The reduction of child and adolescent deaths (defined as decedents aged 0–19 years) remains a crucial public health priority also in high-income countries such as Finland. There is evidence of a relationship between socioeconomic gradients and child mortality, but the association is considered complex and relatively poorly understood. Exploiting a Finnish dataset with nationwide coverage, the present study aimed to shed light on the sociodemographic predictors of child and adolescent mortality at the municipality level.Methods: A public database of Statistics Finland was queried for municipality-level data on sociodemographic traits and child and adolescent deaths in Finland during the years 2011–2018. The sociodemographic indicators included total population size, child and adolescent population size, sex distribution, mean age, education, unemployment, median income, population density, rurality, percentage of individuals living in their birth municipality, household size, overcrowded households, foreign language speakers, divorce rate, car ownership rate, and crime rate. The sociodemographic indicators were modeled against child and adolescent mortality by means of generalized estimating equations.Results: A total of 2,371 child and adolescent deaths occurred during the 8-year study period, yielding an average annual mortality rate of 26.7 per 100,000 individuals. Despite a fluctuating trend, the average annual decline in child and adolescent deaths was estimated to be 3% (95% confidence interval 1–5%). Of the sociodemographic indicators, population density was associated with higher child and adolescent mortality (rate ratio 1.03, 95% confidence interval 1.01–1.06), whereas the percentage of foreign language speakers was associated with lower child and adolescent mortality (0.96, 0.93–0.99).Conclusion: Densely populated areas should be the primary focus of efforts to reduce child and adolescent mortality. Of note is also the apparently protective effect of foreign language speakers for premature mortality. Future studies are welcomed to scrutinize the mediating pathways and individual-level factors behind the associations detected in this study.
Reproducibility of the Geomagnetically Induced Currents at Middle Latitudes During Space Weather Disturbances
Authors: Kikuchi Takashi , Ebihara Yusuke , Hashimoto Kumiko. K. , Kitamura Kentaro , Watari Shin-Ichi 
Published: October 2021

Watari et al. (Space Weather, 2009, 7) found that the geomagnetically induced current (GIC) in Hokkaido, Japan (35.7° geomagnetic latitude (GML)), is well correlated with the y-component magnetic field (By) (correlation coefficients &gt;0.8) and poorly correlated with Bx,z and dBx,y,z/dt. The linear correlation with By would help predict the GIC, if we have capabilities of reproducing the magnetosphere–ionosphere currents during space weather disturbances. To validate the linear correlation with By for any periods (T) of disturbances, we made correlation analyses for the geomagnetic sudden commencements and pulsations (T = 1–10 min), quasi-periodic DP2 fluctuations (30 min), substorm positive bays (60 min), geomagnetic storms (1–20 h), and quiet-time diurnal variations (8 h). The linear correlation is found to be valid for short periods (cc &gt; 0.8 for T &lt; 1 h) but not for long periods (cc &lt; 0.3 for T &gt; 6 h). To reproduce the GIC with any periods, we constructed one-layer model with uniform conductor and calculated the electric field (IEF) induced by By using the convolution of dBy/dt and the step response of the conductor. The IEF is found to be correlated with the GIC for long periods (cc &gt; 0.9), while the GIC-By correlation remains better for short periods. To improve the model, we constructed a two-layer model with highly conductive upper and less conductive lower layers. The IEF is shown to reproduce the GIC with cc &gt; 0.9 for periods ranging from 1 min to 24 h. The model is applied to the GIC measured at lower latitudes in Japan (25.3° GML) with strong By dependence. The mechanism of the strong By dependence of the GIC remains an issue, but a possible mechanism for the daytime GIC is due to the zeroth-order transverse magnetic (TM0) mode in the Earth-ionosphere waveguide, by which the ionospheric currents are transmitted from the polar to equatorial ionosphere.