bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clopidogrel response predicts thromboembolic events associated with coil embolization of unruptured intracranial aneurysms: A prospective cohort study
Authors: Higashi Eiji , Matsumoto Shoji , Nakahara Ichiro , Hatano Taketo , Ishii Akira , Sadamasa Nobutake , Ohta Tsuyoshi , Ishihara Takuma , Tokunaga Keisuke , Ando Mitsushige , Chihara Hideo , Furuta Konosuke , Hashimoto Tetsuya , Tanaka Koji , Sonoda Kazutaka , Koge Junpei , Takita Wataru , Hashikawa Takuro , Funakoshi Yusuke , Kondo Daisuke , Kamata Takahiko , Tsujimoto Atsushi , Matsushita Takuya , Murai Hiroyuki , Matsuo Keitaro , Kitazono Takanari , Kira Junichi 
Published: April 2021

Objective
Periprocedural thromboembolic events are a serious complication associated with coil embolization of unruptured intracranial aneurysms. However, no established clinical rule for predicting thromboembolic events exists. This study aimed to clarify the significance of adding preoperative clopidogrel response value to clinical factors when predicting the occurrence of thromboembolic events during/after coil embolization and to develop a nomogram for thromboembolic event prediction.

Methods
In this prospective, single-center, cohort study, we included 345 patients undergoing elective coil embolization for unruptured intracranial aneurysm. Thromboembolic event was defined as the occurrence of intra-procedural thrombus formation and postprocedural symptomatic cerebral infarction within 7 days. We evaluated preoperative clopidogrel response and patients’ clinical information. We developed a patient-clinical-information model for thromboembolic event using multivariate analysis and compared its efficiency with that of patient-clinical-information plus preoperative clopidogrel response model. The predictive performances of the two models were assessed using area under the receiver-operating characteristic curve (AUC-ROC) with bootstrap method and compared using net reclassification improvement (NRI) and integrated discrimination improvement (IDI).

Results
Twenty-eight patients experienced thromboembolic events. The clinical model included age, aneurysm location, aneurysm dome and neck size, and treatment technique. AUC-ROC for the clinical model improved from 0.707 to 0.779 after adding the clopidogrel response value. Significant intergroup differences were noted in NRI (0.617, 95% CI: 0.247–0.987, p < .001) and IDI (0.068, 95% CI: 0.021–0.116, p = .005).

Conclusions
Evaluation of preoperative clopidogrel response in addition to clinical variables improves the prediction accuracy of thromboembolic event occurrence during/after coil embolization of unruptured intracranial aneurysm.
Low vs standardized dose anticoagulation regimens for extracorporeal membrane oxygenation: A meta-analysis
Authors: Lv Xiaochai , Deng Manjun , Wang Lei , Dong Yi , Chen Liangwan , Dai Xiaofu 
Published: April 2021

BackgroundTo compare the safety and efficacy of low-dose anticoagulation (LA) with that of standardized dose anticoagulation (SA) for patients supported with extracorporeal membrane oxygenation (ECMO).MethodsPubMed, MEDLINE, the Cochrane Library, and Web of Science were screened for original articles. Screening was performed using predefined search terms to identify cohort studies reporting the comparison of LA with SA in patients supported with ECMO from Nov 1990 to Jun 2020. The effect size was determined by the odds ratio (OR) with the 95% confidence interval (CI).ResultsAn analysis of 7 studies including a total of 553 patients was performed. LA (Low-heparin group) was administered to 255 patients, whereas the other 298 patients received SA (Full-heparin group). The incidence of gastrointestinal tract hemorrhage (OR 0.36, 95% CI 0.20–0.64) and surgical site hemorrhage (OR 0.43, 95% CI 0.20–0.94) were significantly lower in patients who underwent LA compared with that in those who underwent SA. The rates of hospital mortality (OR 0.81, 95% CI 0.42–1.56), successfully weaning off of ECMO (OR 0.80, 95% CI 0.30–2.14), pulmonary embolism (OR 0.79, 95% CI 0.24–2.65), intracardiac thrombus (OR 0.34, 95% CI 0.09–1.30), intracranial hemorrhage (OR 0.62, 95% CI 0.22–1.74), and pulmonary hemorrhage (OR 0.77, 95% CI 0.30–1.93) were similar between the two groups.ConclusionsThis meta-analysis confirms that LA is a feasible and safe anticoagulation strategy in patients supported by ECMO. Future studies should focus on the long-term benefits of LA compared with SA.
Measuring depression in adolescence: Evaluation of a hierarchical factor model of the Children’s Depression Inventory and measurement invariance across boys and girls
Authors: Jelínek Martin , Květon Petr , Burešová Iva , Klimusová Helena 
Published: April 2021

BackgroundOne of the most widely used instruments to measure depression in childhood and adolescence is Kovacs’s Children’s Depression Inventory (CDI). Even though this particular measure sparked massive interest among researchers, there is no clear consensus about its factorial structure. It has been suggested that inconsistencies in findings can be partly ascribed to the cultural context. The aim of this study was a) to examine and verify the factor structure of CDI in the Czech population and b) to assess gender-related psychometric differences using the mean and covariance structure (MACS) approach and differential item functioning (DIF) analysis.MethodsThe research sample consisted of 1,515 adolescents (ages 12 to 16 years, 53.7% female) from a non-clinical general population. Based on exploratory factor analysis (EFA) on a random subsample (N = 500), we proposed a model that was subsequently tested on the rest of the sample (N = 1,015) using confirmatory factor analysis (CFA). Following the MACS procedure, we assessed measurement invariance in boys and girls. The between-group comparison was further supplemented by a DIF analysis.ResultsThe proposed hierarchical four-factor model (General Symptoms, Negative Self-Concept, Inefficiency, and Social Anhedonia) with a second-order factor of depression fitted the data reasonably well (χ2= 1281.355; df = 320; RMSEA = 0.054, CFI = 0.925). Regarding gender differences, we found no substantial signs of measurement invariance using the MACS approach. Boys and girls differed in first-order latent means (girls scored higher on General Symptoms with a standardized mean difference of 0.52 and on Negative Self-Concept with a standardized mean difference of 0.31). DIF analysis identified three items with differential functioning. However, the levels of differential functioning were only marginal (in two items) or marginal/moderate and the presence of DIF does not substantially influence scoring of CDI.ConclusionIn the general adolescent population in the Czech Republic, the CDI can be considered a reliable instrument for screening purposes in clinical settings and for use in research practice. Instead of the originally proposed five-factor model, we recommend using the newly established four-factor structure. The measure seems to show only marginal psychometric differences with respect to gender, and overall measurement invariance in boys and girls seems to be a tenable assumption.
In Krise und Kränkung mit Hoffnung gekrönt. Reflexionen zu einem Pandemiejahr aus kirchenpraktischer Perspektive
Authors: Bammel Christina-Maria 
Published: April 2021

Abstract
A year of church under pandemic conditions: Taking Christmas as the starting point of God's self-revelation and spiritual reassurance in this shaky and unsettled pandemic world Provost Dr. Christina-Maria Bammel presents in a personal essay her view of the theological, practical, spiritual church-leadership challenges of this time. On the one hand she looks back and attempts to clarify how the church, in its various manifestations, in congregation and regional church, in physical and virtual presence, has acted so far. On the other hand, she looks ahead and proposes how best to respond to current concerns, to long-known phenomena and new processes, i.e. reorganizing parishes for the good of the neighborhood, which have gained relevance and urgency. There is no simple way to speak of a life after Covid 19, but there is a spiritual and material need to accept that from now on, we have to face a future church life with the virus.
Co-pelletization of Industrial Sewage Sludge and Rice Straw: Characteristics and Economic Analysis
Authors: Duangjaiboon Krittidej , Kitiwan Mettaya , Kaewpengkrow Prangthip Rittichote 
Published: April 2021

The disposal of industrial sewage sludge is one of the most serious environmental problems in Thailand. Moreover, the disposal expense is considered as the production cost to the manufacturer. Therefore, the concept of waste-to-energy technology (WTE) is applied to solve this problem. This study aimed to study the effect of sewage sludge and rice straw proportions on the properties of co-pellets. Here, the production of co-pelleted sewage sludge from the canned food industry, combined with biomass (rice straw), was performed using a lab-scale pelletization machine. The pellets consisted of sewage sludge (SS) and rice straw (RS) with sewage sludge ratios of RS100:SS0, RS50:SS50, RS35:SS65, RS25:SS75, and RS0:SS100. The co-pellets produced were characterized for physicochemical properties and calorific heating values. In addition, the benefit to cost ratio (B/C), internal rate of return (IRR), and payback period (PB) from the utilization of co-pellets were studied. The results suggest that the proportion of sewage sludge affects the properties of the co-pellets. The optimum sewage sludge to rice straw ratio at RS0:SS100 is considered to have good fuel combustion properties. It is suitable for the production of co-pellets because of its high volatility and low ash slagging content
The Latest Battle: Depictions of the Calormen in The Chronicles of Narnia
Authors: Howe Andrew 
Published: April 2021

Abstract
Two books in C.S. Lewis’s young adult fantasy series Chronicles of Narnia - The Horse and His Boy and The Last Battle - paint an uncomfortable portrait of the Calormen, the traditional foil for the Narnians. Throughout the text, the Calormen are clearly marked both culturally and racially as Middle Eastern, perhaps specifically as Turkish or Arab in their socio-political power structure with harems, arranged marriages, and facial hair designating status. Even Tashbaan, the capital city of Calormen, reads somewhat like a description of Istanbul. Throughout these two books, the Calormen are portrayed as a sinister and conquest-driven culture threatening the freedom enjoyed by Narnia. This textual indictment is fairly consistent. In demonizing this group, Lewis took part in a literary tradition extending back hundreds of years, a tradition that has enjoyed renewed resonance with increased fears over the growth of Islam. From Sir John Mandeville to post-9/11 concerns over terrorism, western depictions of Islam have often revolved around fear and distrust. The Last Battle is particularly problematic in its allegorical depictions of Islam, as Lewis seems to suggest that salvation is only reserved for those who follow the lion Aslan, clearly marked throughout the series as a stand-in for Jesus Christ.
Enhanced dielectric properties and breakdown strength of polymer/carbon nanotube composites by coating an SrTiO3 layer
Authors: Han Ruolin , Liu Yuping , Shi Jinchao , Chen Guang-Xin , Li Qifang 
Published: April 2021

Abstract
In this work, strontium titanate (STO) was coated on the surface of carbon nanotubes (MWCNTs) through a sol–gel method to form a core–shell structure hybrid powder (STO@MWCNTs). This powder was then added to polydimethylsiloxane to prepare a flexible high-K composite. As coating, STO effectively prevents the overlap and agglomeration of MWCNTs, thereby passivating the percolation threshold of the composite. STO increases the dielectric properties of the composite as a high dielectric ceramic. Under a low filler loading amount of 11 wt%, the dielectric constant and dielectric loss of the composite are 53 and 0.1, respectively. In addition, the composite can still maintain superior breakdown strength and mechanical properties, given the relatively low filler concentration. The enhanced dielectric properties, breakdown strength, and tensile strength make the composite suitable for application as dielectric material in flexible and stretchable energy storage equipment.
Distinct Element Simulation of a Landslide Process
Authors: Zabuski Lesław , Mierczyński Jacek 
Published: April 2021

Abstract
The paper presents a numerical simulation of the development of a catastrophic landslide in a sandstone quarry and methods of reconstructing the quarry to its previous condition from before the landslide. The important objective of the paper is to present the capabilities of the numerical method used in the analysis of the landslide process, namely the Distinct Element Method (DEM). This method is poorly known, though it is capable of solving important geotechnical problems in which massive displacements are modelled. The features of the method are presented on the basis of a case study. Therefore a numerical analysis is carried out to show the performance of DEM in generating a displacement of several dozen meters in the example of a catastrophic landslide that occurred some years ago in a sandstone quarry. This engineering problem makes it possible to describe and analyse the mechanisms, causes and consequences of the landslide.
Endoscopic negative pressure therapy (ENPT) of a spontaneous oesophageal rupture (Boerhaave’s syndrome) with peritonitis – a new treatment option
Authors: Loske Gunnar , Albers Katrin , Mueller Christian T. 
Published: April 2021

Abstract

Objectives
Boerhaave’s syndrome is a life-threatening disease with high mortality and morbidity. Endoscopic negative pressure therapy (ENPT) can be used to treat oesophageal perforations.

Case presentation
We report on a case of oesophageal rupture with peritonitis in a 35-year-old male patient. The start of treatment was 11 h after the perforation event. The treatment of the perforation defect was performed exclusively by intraluminal ENPT, the treatment of peritonitis was performed by laparotomy with abdominal lavage. For ENPT we used two different types of open-pore drains. The first treatment cycle of four days was performed with an open-pored polyurethane foam drainage (OPD), which was placed intraluminal to cover the perforation defect and to empty the stomach permanently. The second treatment cycle of nine days was performed with a thin nasogastric tube like double-lumen open-pored film drainage (OFD). For suction OPD and OFD were connected with an electronic vacuum pump (−125 mmHg). OFD enables active gastric emptying with simultaneous intestinal feeding via an integrated feeding tube. Intraluminal ENPT with a total treatment duration of 13 days was able to achieve the complete healing of the defect. Surgical treatment of the perforation defect was not necessary. The patient was discharged 20 days after initial treatment with a non-irritating abdominal wound and a closed perforation.

Conclusions
In suitable cases, endoscopic negative pressure therapy is a minimally invasive, organ-preserving procedure for the treatment of spontaneous oesophageal rupture.
The effect of spiritual care on quality of life of patients with amputation caused by diabetes type 2: a clinical trial
Authors: Sabouhi Fakhri , Mohtashami Mona Joz , Mohammadpourhodki Reza , Mahdavi Sepideh , Khalili Mitra , Imeni Malihe 
Published: April 2021

Abstract

Objectives
This study aimed to investigate effect of a spiritual care on quality of life of patients with amputation caused by diabetes type 2.

Methods
The current study was a clinical trial. Fifty four patients with amputation caused by diabetes type 2 referred to Al-Zahra hospital at Isfahan was allocated to two case and control groups. Spiritual care training including transcendental meditation (T.M) technique was established for case group. Participants in case group performed four weeks of meditation technique following participating in sessions of meditation technique training. Data gathering was done using a standard tool to assess quality of life in patients with diabetes (diabetes quality of life: DQOL). Data was analyzed using SPSS software.

Results
Mean score of quality of life in the four areas of quality of life was not significantly different among case and control groups at baseline, however, mean score of quality of life in case group (2.25 ± 0.56) was significantly better than control group (2.52 ± 0.38) after intervention (p<0.001).

Conclusions
Given findings of the study, it seems that spiritual care can improve quality of life of patients with amputation caused by diabetes type 2.
Analytical solutions to some generalized and polynomial eigenvalue problems
Authors: Deng Quanling 
Published: April 2021

AbstractIt is well-known that the finite difference discretization of the Laplacian eigenvalue problem −Δu=λuleads to a matrix eigenvalue problem (EVP)Ax=λxwhere the matrixAis Toeplitz-plus-Hankel. Analytical solutions to tridiagonal matrices with various boundary conditions are given in a recent work of Strang and MacNamara. We generalize the results and develop analytical solutions to certain generalized matrix eigenvalue problems (GEVPs)Ax=λBxwhich arise from the finite element method (FEM) and isogeometric analysis (IGA). The FEM matrices are corner-overlapped block-diagonal while the IGA matrices are almost Toeplitz-plus-Hankel. In fact, IGA with a correction that results in Toeplitz-plus-Hankel matrices gives a better numerical method. In this paper, we focus on finding the analytical eigenpairs to the GEVPs while developing better numerical methods is our motivation. Analytical solutions are also obtained for some polynomial eigenvalue problems (PEVPs). Lastly, we generalize the eigenvector-eigenvalue identity (rediscovered and coined recently for EVPs) for GEVPs and derive some trigonometric identities.
Comparison of the strength development of binary and ternary cements containing perlite powder
Authors: Sičáková Alena , Figmigová Erika , Špak Matej 
Published: April 2021

Abstract
Currently, the consumption of blended cements is increasing all over the world. This is due to environmental, technical and economic reasons. Among the additives mixed with ordinary Portland cement, ground granulated blast furnace slag and fly ash are of particular significance. However, some regions may lack standard additives, and vice versa, may be rich in natural pozzolans. This paper is focused on the perlite as a natural pozzolanic material which is locally available. This study presents the results of the application of perlite as a component of blended cements in different proportions, representing binary and ternary compositions, and compares it with standard additives (fly ash and ground granulated blast furnace slag). The time development of both compressive and flexural strength, including results of 2, 7, 28 and 90-day testing, is analyzed. Perlite binders show acceptable time development of strengths, which is comparable to conventional blended binders based on ground granulated blast furnace slag and fly ash and do not constitute a technological barrier. With a higher dose of perlite, the time increase in flexural strength is slower, but the rate of increase in compressive strength does not change substantially. Flexural strength of 4.1–6.2 MPa and compressive strength of 18.8–38.5 MPa are sufficient for a number of practical applications and are expected to meet the required limits. An improvement of strengths in the later period (90 days) was also confirmed.
Transition readiness among adolescents with rare endocrine conditions
Authors: van Alewijk Lisette , Davidse Kirsten , Pellikaan Karlijn , van Eck Judith , Hokken-Koelega Anita C S , Sas Theo C J , Hannema Sabine , van der Lely Aart J , de Graaff Laura C G 
Published: April 2021

Objective
Adolescents and young adults (AYA) with common endocrine disorders show a high dropout (up to 50%) after the transfer from paediatric to adult endocrinology. Little is known about transition readiness in rare endocrine conditions (rEC). This study aims to assess medical self-management skills (SMS) among AYA with rEC in relation to age and gender, in order to understand dropout and increase transition readiness.

Design
Cross-sectional study using web-based medical self-management questionnaires.

Methods
Questionnaires consisting of 54 questions in seven domains were filled out by the adolescents before the first shared appointment with both paediatric and adult endocrinologist.

Results
Fifty-seven patients (median age 17 years, 25/57 females) participated and generally scored well on most items. However, one out of seven did not know the name of their disorder, one sixth of the glucocorticoid users did not know that dose should be adapted in case of illness or surgery, over one-fifth had never ordered their repeat prescriptions themselves and two-thirds had never had a conversation alone with their doctor.

Conclusions
Several SMS among patients with rEC are insufficient, with regard to medical knowledge, practical skills and communication. As SMS are only weakly related to non-modifiable factors, such as age and gender, we recommend focussing on other factors to increase transition readiness. The timing, amount and ‘mode’ of medical information should be individualised. Transition checklists should be used to detect shortcomings in practical skills and communication, which can subsequently be trained with the help of parents, caregivers and/or e-technology.
Tourmalines of the Velence Granite Formation and the surrounding contact slate, Velence Mountains, Hungary
Authors: Fehér Béla , Zajzon Norbert 
Published: April 2021

AbstractThree distinct paragenetic and compositional types of tourmaline were described from the Velence Granite and the surrounding contact slate. Rare, pitch-black, disseminated tourmaline I (intragranitic tourmaline) occurs in granite, pegmatite, and aplite; very rare, black to greenish-gray, euhedral tourmaline II (miarolitic tourmaline) occurs in miarolitic cavities of the pegmatites; abundant, black to gray, brown to yellow or even colorless, acicular tourmaline III (metasomatic tourmaline) occurs in the contact slate and its quartz-tourmaline veins. Tourmaline from a variety of environments exhibits considerable variation in composition, which is controlled by the nature of the host rock and the formation processes. However, in similar geologic situations, the composition of tourmaline can be rather uniform, even between relatively distant localities. Tourmaline I is represented by an Al-deficient, Fe3+-bearing schorl, which crystallized in a closed melt-aqueous fluid system. Tourmaline II is a schorl-elbaite mixed crystal, which precipitated from Li- and F-enriched solutions in the cavities of pegmatites. Tourmaline III shows an oscillatory zoning; its composition corresponds to schorl, dravite, and foitite species. It formed from metasomatizing fluids derived from the granite. This is the most abundant tourmaline type, which can be found in the contact slate around the granite.