bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stigma associated with and attitude regarding mental health help-seeking among undergraduate nursing students in Karachi, Pakistan
Authors: Farooq Salima , Parpio Yasmin , Sattar Saadia , Ali Zahra , Rahim Shirin , Peerwani Ghazal 
Published: July 2021

Abstract
Background
Globally, the prevalence of mental illness amongst university students is a major concern; same is the case with nursing students. Unaddressed mental illness stigma contributes towards hiding of symptoms hampers timely identification of the disease, and leads to reluctance in attitude towards seeking help. This study determined personal and perceived depression stigma and attitude towards help-seeking behaviors and its associated factors, among undergraduate nursing students at a private nursing institution in Karachi, Pakistan.
Methods
We conducted a cross-sectional study by recruiting 246 first and second-Year undergraduate nursing students using consecutive sampling. Data were collected using the Depression Stigma Scale (DSS) and the Attitude toward Seeking Professional Psychological Help Scale (ATSPPHS), along with a demographic questionnaire. Chi-square test, Fischer’s exact test and student T test were used to determine significance of difference of each response between first and second year students. Multiple linear regression was employed to determine predictors of DSS and ATSPPHS. Approval was obtained from the university’s Ethics Review Committee.
Results
The study findings revealed that the mean scores of the personal and perceived stigma scales were 29.7 ± 4.9 and 24.3 ± 6.1, respectively. The mean score of ATSPPHS was 16.5 ± 3.8. The participants reported a mean openness score of7.8 ± 2.6 and a value scale score of 8.7 ± 3.0. A history of psychiatric illness, current living arrangements, and personal depression stigma were found to be significant predictors of ATSPHHS. The year of study was a significant predictor of personal depression stigma whereas both years of study and the current living arrangements were significantly associated with perceived depression stigma.
Conclusion
Attitude towards seeking help for mental illness was significantly influenced by personal and perceived stigma. Moreover, previous history of psychiatric illness and living arrangements also predicted attitudes towards seeking help. In order to encourage positive attitudes towards seeking help for students’ well-being, it is essential to destigmatize mental health issues by adapting context-based, individualized, and group mental health interventions.
Comparative Analysis of Long Non-Coding RNA and mRNA Expression Provides Insights Into Adaptation to Hypoxia in Tibetan Sheep
Authors: Wang Fan , Liu Jianbin , Zeng Qiaoying , Zhuoga Deqing 
Published: July 2021

Abstract
Tibetan sheep have lived on the Qinghai-Tibetan Plateau for thousands of years and they have a good adaptability to the hypoxic environment and strong disease resistance. However, the molecular mechanism of the Tibetan sheep adapting to this extreme environment, especially the role of genetic regulation is still unknown. Emerging evidence suggests that long non-coding RNAs (lncRNAs) participate in the regulation of a diverse range of biological processes. To explore the potential lncRNAs involved in Tibetan sheep adapting to high altitude hypoxia environment, we analyzed the expression profile of lncRNAs and mRNAs in liver and lung tissue of sheep based on the comparative transcriptome analysis between four Tibetan sheep populations (high altitude) and Hu sheep (low altitude). The results showed a total of 7848 differentially expressed (DE) lncRNAs transcripts and 22971 DE mRNAs transcripts were detected by pairwise comparison. The expression patterns of selected mRNAs and lncRNAs were validated by qRT-PCR and the results correlated well with the transcriptome data. Moreover, the functional annotation analysis based on the Gene Ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) databases showed that DE mRNAs and the target genes of the lncRNAs were significantly enriched in organ morphogenesis, response to stimulus, heme binding, immune system, arginine and proline metabolism, and fatty acid biosynthesis. The prediction of mRNA-mRNA and lncRNA-mRNA interaction networks further revealed transcripts potentially involved in adaptation to high altitude hypoxia, the hub genes that DDX24, PDCD11, EIF4A3, NDUFA11, SART1, PRPF8 and TCONS_00306477, TCONS_00306029, TCONS_00139593, TCONS_00293272, TCONS_00313398 were selected. Additionally, a set of target genes, PIK3R1, IGF1R, FZD6, IFNB2, ATF3, MB, CYP2B4, PSMD13, and TGFB1 were also identified as candidate genes associated with high altitude hypoxia adaptation. In conclusion, a collection of aberrantly expressed lncRNA, a set of target genes and biological pathways known to be relevant for altitude adaptation were identified by comparative transcriptome analysis between Tibetan sheep and Hu sheep. Our results first identified the characterization and expression profile of lncRNAs between Tibetan sheep and Hu sheep and provides insights into the genetic regulation mechanisms for Tibetan sheep adaptation to high altitude hypoxia environments.
Identidad de la universidad franciscana en Colombia. Un estudio en perspectiva pedagógica
Authors: Vanegas Carvajal Edgar Alonso 
Published: July 2021

El objetivo de este artículo es mostrar el compromiso de la pedagogía franciscana en la construcción de identidad de la Universidad Franciscana en Colombia. Es decir, se busca indagar acerca de la responsabilidad que tiene la pedagogía franciscana con la identidad en cuatro universidades franciscanas de Colombia. Para ello, se proponen tres escenarios interconectados: se parte de la relación entre franciscanismo y universidad que emerge desde la primera fraternidad franciscana; seguidamente, se analiza la concepción de pedagogía franciscana que declara cada una de las universidades franciscanas de Colombia; finalmente, se proponen líneas y acciones de cooperación interinstitucional entre las universidades franciscanas de Colombia, encaminadas a responder a los retos y desafíos que la globalización le plantea a la universidad moderna.
La investigación es eminentemente documental-descriptiva con enfoque cualitativo de tipo no experimental, puesto que prevaleció un análisis crítico a partir de la revisión y análisis de material bibliográfica seleccionado intencionalmente. En consecuencia, se utilizó como técnica el análisis categorial en los términos propuestos por Corbin y Strauss[1], que parte de un análisis categorial seguido de un estudio comparativo con muestreo teórico.

[1] Juliet Corbin and Anselmo Strauss, Basic of qualitative research: Techniques and procedures for developing grounded theory (Newbury Park, California: SAGE Publications, Inc., 2014), 17.
Glycemic properties of soursop-based ice cream enriched with moringa leaf powder
Authors: Ademosun Ayokunle O. 
Published: July 2021

Introduction. Diabetes is a common disease all over the world that is often a cause of mortality. Ice cream is popular in many countries. However, sugar and fat in its composition makes ice cream a high-caloric product. Soursop (Annona muricata L.) and moringa (Moringa oleifera L.), African medicinal plants, contain natural sugars and are rich in phytochemicals. We aimed to produce ice cream with these plants and evaluate its remedial properties.
Study objects and methods. The study featured ice cream purchased in a local store (control sample) and soursop ice cream with moringa leaf powder (experimental samples). The experimental ice cream samples included ice cream with soursop, ice cream with soursop and 0.1 g of moringa, and ice cream with soursop and 1 g of moringa. The antioxidant properties, glycemic indices, amylose and amylopectin contents, as well as α-amylase and α-glucosidase inhibitory properties of the samples were determined using the standard methods.
Results and discussion. Comparing with the other samples, ice cream with 1 g of moringa showed the highest total phenol and flavonoid contents, ABTS scavenging ability, DPPH radical scavenging ability, hydroxyl scavenging ability, ferric reducing antioxidant properties, and lowest glycemic index. Sensory evaluation revealed a lower overall acceptability of the experimental samples compared to the control ice cream. This could be due a peculiar taste of moringa (the formulation did not include sugar).
Conclusion. Ice cream based on soursop and moringa can be a good alternative to sugar-sweetened ice cream due to its antioxidant properties, low glycemic index, and acceptable sensory attributes.
Continuous hydrolysis of milk proteins in membrane reactors of various configurations
Authors: Ryazantseva Ksenia , Agarkova Eugeniya , Fedotova Olga 
Published: July 2021

Introduction. The article provides a review of technologies for membrane fractionation of various hydrolyzed food substrates in membrane bioreactors (MBR). In food industry, MBRs are popular in functional food production, especially in the processing of whey, which is a very promising raw material due to its physicochemical composition.
Study objects and methods. The research was based on a direct validated analysis of scientific publications and featured domestic and foreign experience in MBR hydrolysis of protein raw material.
Results and discussion. The MBR hydrolysis of proteins combines various biocatalytic and membrane processes. This technology makes it possible to intensify the biocatalysis, optimize the use of the enzyme preparation, and regulate the molecular composition of hydrolysis products. The paper reviews MBRs based on batch or continuous stirring, gradient dilution, ceramic capillary, immobilized enzyme, etc. Immobilized enzymes reduce losses that occur during the production of fractionated peptides. Continuous MBRs are the most economically profitable type, as they are based on the difference in molecular weight between the enzyme and the hydrolysis products.
Conclusion. Continuous stirred tank membrane reactors have obvious advantages over other whey processing reactors. They provide prompt separation of hydrolysates with the required biological activity and make it possible to reuse enzymes.
The experience of managing children and adolescents with Ewing’s sarcoma in the Pediatric Oncology Department of the Federal State Budgetary Institution “National Medical Research Center of Oncology”, Ministry of Health of Russia
Authors: Yurchenko D. Yu. , Kuznetsov S. A. , Kozel Yu. Yu. , Frantsiyants E. M. , Mkrtchyan G. A. , Pak E. Ye. , Starzhetskaya M. V. , Bespalova A. I. , Popovyan O. P. , Kozuk O. V. , Dmitrieva V. V. 
Published: July 2021

Relevance. One of the leading positions among malignant tumors of the musculoskeletal system in children and adolescents has recently begun to be occupied by Ewing’s sarcoma (ES). The prognosis of patients suffering from this onconosology remains extremely unfavorable even in the absence of distant metastases and timely initiation of antitumor treatment. The authors present 10 years of experience in the management of pediatric and adolescent patients with ES in the pediatric oncology department of the National Medical Research Center of Oncology, Ministry of Health of Russia.Materials and methods. The study included pediatric and adolescent patients diagnosed with ES of I—IV stages of various localizations, who were treated in the Pediatric Oncology Department of the National Medical Research Center of Oncology, Ministry of Health of Russia in the period from 2009 to 2019. We analyzed 2- and 5-year overall (OS) and event-free (EFS) survival in patients who received combined and complex antitumor treatment for various forms of tumor dissemination according to the EURO-EWING 2008protocol, which included neo-and adjuvant polychemotherapy, including high-dose, radical surgical treatment, and also radiation therapy.Results. The median 5-year OS and EFS in the general group of the studied formulations was 60 and 17 months, respectively. The indicators of 2- and 5-year OS and EFS in patients of the general group were 80.6 % and 56.7 %, 38.6 % and 10.6 %, respectively. The volume of the performed antitumor treatment, as well as the form of the advanced tumor process, did not have a significant effect on OS and EFS indicators (p > 0.05). At the same time, the chances of developing ES in boys were statistically significantly higher by 2.2 times in comparison with girls (95 % confidence interval 1.1—4.3).Conclusion. The obtained OS and EFS indices indicate unsatisfactory results of anticancer therapy and extremely high aggressiveness of the biological behavior of the tumor, regardless of the form of spread of the tumor process.
Laparoscopic kidney resection in a child with unilateral Wilms tumor
Authors: Nosov A. K. , Kuleva S. A. , Ivanova S. V. , Senchurov E. M. , Khabarova R. I. , Mikhailova E. A. , Shchekuteev N. A. , Borokshinova K. M. , Gridasov V. V. , Khokhlova A. V. 
Published: July 2021

The modern Wilms tumor treatment protocols used all over the world can cure up to 90 % of children. Such successes make it possible to actively introduce risk-adapted therapy methods aimed at de-escalating the chemotherapy regimen and radiation therapy impact to the tumor. The most conservative was the stage of surgical treatment, implying the organ-depleting nature of the surgery. Nevertheless, over the past decade, a lot of experience has been accumulated with both nephron-sparing and minimally invasive interventions in patients with both bilateral and unilateral Wilms tumor.We presented the experience of laparoscopic kidney resection with intraoperative ultrasound control in a child with unilateral Wilms tumor, receiving treatment at the N.N. Petrov National Medical Research Center of Oncology.
Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia
Authors: Rodionova S. S. , Buklemishev Yu. V. , Karpov I. N. , Shugaeva O. B. , Torgashin A. N. 
Published: July 2021

Background. The rarity of the disease and, in this regard, the lack of doctors awareness about the pathology, late diagnosis and severe complications of the musculoskeletal system emphasize the relevance of clinical case demonstrating. The uniqueness of the case lies in the fact that hypophosphatemia, noted 3 years after the disease debut, was not taken into account.Case description. A 45-year-old patient with complaints of muscle weakness, gait disorders, torso deformity and multiple vertebral body fractures that appeared against the background of any somatic diseases absence, a differential diagnosis of metastatic vertebral bodies lesions and secondary osteoporosis complicated by vertebral body fractures was carried out for four years in various hospitals, and was even treated with bisphosphonates. Against this background, the chest deformity increased, kyphosis and remodeling fractures of other bones appeared. The assessment of calcium and phosphorus homeostasis was first performed at the 4th year of the disease, but the detected hypophosphatemia was not regarded as a manifestation of hypophosphatemic osteomalacia.Conclusion. Among adult patients with multiple low-energy fractures, severe muscle weakness and bone pain that appeared against the background of complete health, to exclude hypophosphatemic osteomalacia induced by mesenchymal tumor, it is necessary to include the level of phosphorus in blood and daily urine assessment in the diagnostic algorithm.
Efficiency of the One-Stage Revision Hip Arthroplasty in Chronic Periprosthetic Joint Infection with Sinus Tract
Authors: Artyukh V. A. , Bozhkova S. A. , Boyarov A. A. , Muravyova Ju. V. , Kochish A. A. 
Published: July 2021

Background. Chronic periprosthetic joint infection (PJI) remains the one among the most severe complications of total hip arthroplasty. Presence of sinus tract assosiated with polymicrobial infection development, complexity of bacteriological diagnostics and damage of soft tissues lead to constrictions of one-stage revision hip arthroplasty (RHA). The aim of this studywas to assess the influence of draining sinus tract on the outcomes of one-stage RHA in patients with chronic hip PJI.Materials and Methods.A prospective cohort comparative study included 78 patients who underwent one-stage RHA in 2017-2020. Two groups were formed: 48 (61.54%) patients without sinus tract (WST) and 30 (38.45%) patients with sinus tract (ST).Results. The presence of a sinus tract significantly increased the duration of a one-stage RHA in groups of ST and WST (230 and 197.5 min respectively, p = 0.02), as well as blood loss (850 ml and 700 ml, respectively, p = 0.046). Sinus tract was a reliable symptom of soft tissue local infectious inflammation (86.67%, p = 0.00031), fasciitis (36.67%, p = 0.012), purulent cavity (66.67%, p = 0.00027). The structure of the pathogens was comparable. Monobacterial infections predominated in the WST group (82.98%) and in the ST group (77.78%, p = 0.08). In most cases staphylococci were isolated. The median follow-up was 20 months for both groups. The PJI was healed in 93.0% (n = 28) patients in WST group and 82.2% (n = 43) in ST PJI (p0.05). Postoperative evaluation in the WST and ST groups: HHS 92 and 90 points (p = 0.79), EQ-5D-5L – 0.82 and 0.78 points (p = 0.84) respectively. The proportion of patients who were indicated revision surgery with no PJI association in the ST group exceeded this indicator more than twice according to the WST group — 25 and 11.62%, respectively (p0.05).Conclusion.As a result of the study, there was no statistically significant difference between the outcomes of one-stage RHA in patients with and without sinus tract. Factors such as the anamnesis morbi, the soft tissues condition at the surgical site and the pathogenic microflora characteristics should be taken into account in order to achieve favourable outcomes of surgical treatment.
Criterios de Vancouver: Cómo citar y presentar referencias en documentos académicos
Authors: Mendoza-Núñez Víctor Manuel 
Published: July 2021

Una cita bibliográfica es la especificación (número o autor/año) que se inserta en el texto para identificar la fuente que sustenta los datos, aseveraciones, ideas, teorías o investigaciones que se presentan o analizan en los documentos. Por otro lado, las referencias bibliográficas son los datos completos (autores, titulo, datos editoriales) de un documento académico (libro, artículo, tesis, memoria) o páginas web de organismos internacionales, universidades o asociaciones profesionales, con reconocimiento académico. En este sentido, los datos incluidos deben garantizar que el documento o información de la página web pueden ser recuperados para verificar lo señalado en el documento académico o científico que se esté elaborando. 1 Las referencias completas se listan al final del documento elaborado.
Recolección de Residuos Tecnológicos aplicando Metaheurísticas
Authors: Pérez Diana , Pandolfi Daniel , Villagra Andrea 
Published: July 2021

La creciente demanda en el uso las tecnologías de la información y comunicación (TIC) han revolucionado nuestra vida cotidiana, sin embargo, han contribuido a aumentar las preocupaciones ambientales y sociales. La aceleración de factores como el agotamiento y escasez de recursos, daños ambientales, uso de agua y energía y un incremento insostenible de desechos tecnológicos principalmente en zonas urbanas, se ha convertido en una preocupación para la industria y el gobierno. La recuperación de residuos tecnológicos requiere de estrategias inteligentes de recolección que minimicen los costos asociados, maximicen el reúso de materias primas y la reparabilidad de los bienes para la prolongación de su vida útil. Uno de los factores que inciden fuertemente, es el costo de recorrido para la recolección.

Este trabajo consiste en generar rutas recolección dado una cantidad de clientes por atender, un conjunto de vehículos de recolección, permitiendo minimizar ciertos factores que ayuden a la empresa a obtener beneficios. Los objetivos pueden ser: minimizar el tiempo de reparto, maximizar el ahorro de combustible en los vehículos, minimizar la cantidad de vehículos de reparto, todo lo cual llevaría a obtener menores costos y por lo tanto obtener beneficios y una mejor calidad de servicio e imagen. Particularmente, el propósito de este trabajo es mostrar como la aplicación de un algoritmo basado en inteligencia colectiva (metaheurística) mejora la planificación de recolección de residuos tecnológicos para un caso de estudio en la localidad de Comodoro Rivadavia sobre con diferentes escenarios e instancias de recolección con 75, 105, 150 y 200 contenedores de residuos y vehículos con diferentes capacidades. Se realiza además un análisis de la reducción de gases emitidos.
Comprensión de la derivada apoyada en la ingeniería didáctica como método de investigación
Authors: Saraza-Sosa Dilan Fabián , Prada-Núñez Raúl , Vera-Gutiérrez Charen Lisset 
Published: July 2021

El cálculo diferencial ha tenido diversas dificultades en el entendimiento de sus diversos conceptos, en especial en el tema de la derivada, donde se ha registrado que los estudiantes desarrollan una asimilación de tipo algorítmico y mecánico en la aplicación de sus reglas de derivación, despreciando la construcción gráfica y visual, la cual es importante para un desarrollo óptimo del saber mencionado. Por lo anterior se implementó la metodología de ingeniería didáctica en el tema de la derivada, con el fin de sentar bases de tipo epistémico y documental para conocer cuáles son las situaciones que generalmente se presenta entorno a la enseñanza de este saber, en base a lo anterior se aplicó una prueba de conocimiento para identificar el grado de comprensión adquirido por los docentes en formación de programa académico de Licenciatura en Matemática de la Universidad Francisco de Paula Santander, a fin de establecer lineamiento para la estructuración de unas secuencias didácticas que fomento un aprendizaje óptimo de la derivada.
La maleta viajera de Euclides, como estrategia didáctica para fortalecer el pensamiento espacial y los sistemas geométricos
Authors: Marín-Arguello Leidy Katerine 
Published: July 2021

El desarrollo del pensamiento, incide de manera progresiva en la formación integral de los sujetos, al respecto, se hizo necesario desarrollar la presente investigación, cuyo objetivo general fue: Fortalecer el pensamiento espacial y los sistemas geométricos en los estudiantes de noveno grado del colegio Los Santos Apóstoles mediante la estrategia didáctica, la Maleta Viajera de Euclides, para ello, se adelantó una metodología enmarcada en los postulados de la investigación acción, donde se consideró la puesta en marcha de cuatro fases de manera sistemática, al respecto se asumió la planificación en primer lugar, en esta se diseñaron todos los elementos que contendría la Maleta Viajera de Euclides para el desarrollo del pensamiento espacial y los sistemas geométricos en los estudiantes de grado noveno, seguidamente se presenta la acción, donde se ejecutaron las situaciones diseñadas, en este caso, se evidencia un conjunto de intervenciones, las cuales iniciaron con formas geométricas planas, para posteriormente transformarlas en tridimensionales, para lo cual, los estudiantes representaron disposición e interés en el desarrollo de las actividades, las actividades fueron valoradas mediante la observación directa no participante, para dar paso a la reflexión, donde se logró determinar que la Maleta Viajera de Euclides posee un impacto significativo en la enseñanza y el aprendizaje de los conocimientos inherentes al pensamiento espacial y los sistemas geométricos.