bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Profiling Using The UltraSEEK Panel Identifies Discordancy Between Paired Primary And Breast Cancer Brain Metastases And An Association With Brain Metastasis-Free Survival
Authors: Palmieri Carlo , Giannoudis Athina , Sartori Alexander , Eastoe Lee , Zakaria Rasheed , Charlton Christopher , Hickson Nicholas , Platt-Higgins Angela , Rudland Philip S. , Irwin Darryl , Jenkinson Michael D. 
Published: April 2021

Abstract
Purpose. Brain metastases (BM) are an increasing clinical problem. This study aimed to assess paired primary breast cancers (BC) and BM for aberrations within TP53, PIK3CA, ESR1, ERBB2 and AKT utilising the MassARRAY® UltraSEEK® technology (Agena Bioscience, San Diego, USA). Methods. DNA isolated from 32 paired primary BCs and BMs was screened using the custom UltraSEEK® Breast Cancer Panel. Data acquisition and analysis was performed by the Agena Bioscience Typer software v4.0.26.74. Results. Mutations were identified in 91% primary BCs and 88% BM cases. TP53, AKT1, ESR1, PIK3CA and ERBB2 genes were mutated in 68.8%, 37.5%, 31.3%, 28.1% and 3.1% respectively of primary BCs and in 59.4%, 37.5%, 28.1%, 28.1% and 3.1% respectively of BMs. Differences in the mutations within the 5 genes between BC and paired BM were identified in 62.5% of paired cases. In primary BCs, ER-positive/HER2-negative cases harboured the most mutations (70%), followed by ER-positive/HER2-positive (15%) and triple-negatives (13.4%) whereas in BMs, the highest number of mutations was observed in triple-negatives (52.5%), followed by ER-positive/HER2-negative (35.6%) and ER-negative/HER2-positive (12%). There was a significant association between the number of mutations in the primary BC and breast-to-brain metastasis-free survival (p=0.0001) but not with overall survival (p=0.056). Conclusion. These data demonstrate the discordancy between primary BC and BM, as well as the presence of clinically important, actionable mutations in BCBM. The UltraSEEK® Breast Cancer Panel provides a tool for BCBM that can be utilised to direct more tailored treatment decisions and for clinical studies investigating targeted agents.
An evaluation of a combined psychological and parenting intervention for HIV-positive women depressed in the perinatal period, to enhance child development and reduce maternal depression: Study Protocol for the Insika Yomama Cluster Randomised Controlled Trial
Authors: Rochat Tamsen , Dube Sam , Herbst Kobus , Hoegfeldt Cecilia , Redinger Stephanie , Khoza Thandeka , Bland Ruth Margret , Richter Linda , Linsell Louise , Desmond Chris , Yousafzai Aisha K. , Craske Michelle , Juszczak Ed , Abas Melanie , Edwards Taygen , Ekers David , Stein Alan 
Published: April 2021

Abstract
Background: The combination of poverty, HIV and depression in the perinatal period represents a major public health challenge in many Southern African countries. In some areas, up to a third of HIV-positive women experience perinatal depression. Perinatal depression is associated with negative effects on parenting and key domains of child development including cognitive, behavioural and growth, especially in socio-economically disadvantaged communities. Several studies have documented the benefits of psychological interventions for perinatal depression in low- and middle-income countries, but none have evaluated an integrated psychological and parenting intervention for HIV-positive women using task-sharing. This randomised controlled trial aims to evaluate the effect of a home-based intervention, combining a psychological treatment for depression and a parenting programme for perinatally depressed HIV-positive women. Methods: This study is a cluster-randomised controlled trial, consisting of 48-60 geospatial clusters. A total of 528 pregnant HIV-positive women aged ≥16 years who meet the criteria for depression on the Edinburgh Postnatal Depression Scale (EPDS, score ≥9)) are recruited from antenatal clinics in rural KwaZulu-Natal, South Africa. The geospatial clusters are randomised on an allocation ratio of 1:1 to either the intervention or Enhanced Standard of Care. The intervention group receives 10 home-based counselling sessions by a lay-counsellor (4 antenatal and 6 postnatal sessions) and a booster session at 16 months. The intervention combines Behavioural Activation for depression with a parenting programme, adapted from the UNICEF/WHO Care for Child Development programme. The ESoC group receives two antenatal and two postnatal support and advice telephone calls. The co-primary outcomes are child cognitive development at 24 months assessed on the cognitive sub-scale of the Bayley Scales of Infant Development-Third Edition and maternal depression at 12 months measured by the EPDS. Analysis: The primary analysis will be a modified Intention-to-Treat analysis. The primary outcomes will be analysed using mixed-effects linear regression. Discussion: If this treatment is successful, policymakers could use this model of mental health-care delivered by lay-counsellors within HIV treatment programmes to provide more comprehensive services for families affected by HIV.
Solar Light-Driven Photocatalysis Using BaFe2O4/rGO for Chlorhexidine Digluconate Contaminated Water: Comparison With Artificial UV and Visible Light-Mediated Photocatalysis
Authors: Singh Astha , Mishra Brijesh Kumar 
Published: April 2021

Abstract
Synthesis and characterization of dual functioning material is an effective approach for promotion of organic pollutant degradation through adsorption as well as photocatalysis. Herein, graphene oxide modified by addition of barium nitrate and iron to construct smooth sheet-like structure (BaFe2O4/rGO) for removal of Chlorhexidine Digluconate (CHD). Compare with GO (75.69% -UV-light ;88.17%-visible-light), BaFe2O4/rGO showed significant adsorption-photocatalysis effect under visible-light (93.95%) than UV-light (78.17%). The introduction of barium nitrate and iron into graphene oxide led to smooth porous structure with increased surface area (93.66 m2 g-1), which resulted in large number of adsorption active site and great photocatalytic activity with efficient charge separation. Although, catalysts did not mineralize CHD completely, but the parent compound mineralized to some extent, which was confirmed by the TOC measurement and UV254 absorbance variation. In addition, toxicity of degraded products was analyzed by bacterial susceptibility test on Bacillus cereus DPAML065 suggested that nontoxic byproducts of CHD formed, which led to their safe disposal. Based on the identified transformed products, the possible degradation pathway was proposed. Batch studies demonstrated that BaFe2O4/rGO is highly photoactive based on reaction rate constant (R2=0.984), where the kinetics data was well-fitted using the pseudo-first order. Moreover, efficiency of catalysts was examined under solar light to achieve the sustainability.
The Influence of Urban Haze Pollution on Urban Shrinkage in China – An Analysis of the Mediating Effect of the Labour Supply
Authors: Liu Xiaohong 
Published: April 2021

Abstract
Panel data of 234 cities in China from 2011 to 2018 is used to measure the urban shrinkage index. PM2.5 is used as an indicator of haze pollution, and labour supply is the mediator. On this basis, the influence mechanism of haze pollution on urban shrinkage is analysed theoretically. Next, using the dynamic panel model and the mediating effect model, we empirically examine the impact of urban shrinkage on haze pollution and the mediating effect of labour supply. The main findings are as follows: haze pollution increases the degree of urban shrinkage, and labour supply plays a regulatory role in the process of haze pollution affecting urban shrinkage. According to our research, pertinent policies and suggestions are proposed to reduce both urban shrinkage and haze pollution.
Does Resource Abundance Require Special Approaches to Climate Policies? The Case of Russia
Authors: Makarov Igor 
Published: April 2021

Abstract
As the world’s largest fossil fuels exporter, Russia is one of the key countries for addressing global climate change. However, it has never demonstrated any significant ambitions to reduce greenhouse gas (GHG) emissions. This paper applies ideational research methodology to identify the structural differences in economic, political, and social normative contexts between industrialized fossil fuel importing economies and Russia that lead to the fundamental gap in motivations driving decarbonization efforts. Consequently, Russia is unlikely to replicate the approach to the green transition and use instruments of climate policies which are utilized in energy-importing countries. In order to launch decarbonization in Russia, interested stakeholders need to frame climate policies in Russia differently. Specifically, the framing must address the priority of diversification as a means to adapting the national economy to a new green landscape, the combination of diverse channels for decarbonization, the promotion of energy-efficiency, closer attention to climate-related forest projects and linkage of climate change with other environmental problems. Moreover, considering Russia’s emissions as a part of the global economic system and shifting from a simplistic national focus on GHG emissions reduction would help coordinate policies through dialogue between exporters and importers of fossil fuels energy-intensive goods, which is essential for the global movement towards a net-zero future.
Does industrial collaborative agglomeration improve environmental efficiency? Insights from China's population structure
Authors: Zhu Yue , Du Wenbo , Zhang Juntao 
Published: April 2021

Abstract
It is the theme of today to develop green economy and improve environmental efficiency (EE). As a comprehensive index to measure energy input, economic output and environmental development, environmental efficiency (EE) is of great significance for China to realize the sustainable development of economy and environment. China is in a critical period of industrial transformation and upgrading and ecological civilization construction, the effect of the collaborative agglomeration of manufacturing and productive services on environmental efficiency has drawn attention from policymakers. In this study, the stochastic frontier approach (SFA) with unpaid input is used to measure the environmental efficiency (EE) of 66 cities in eastern China during 2009–2018. Population structure is regarded as a mediator to investigate the impact of industrial collaborative agglomeration on environmental efficiency based on the spatial econometric model. The results show that industrial collaborative agglomeration has a positive impact on environmental efficiency, which can be moderated by population density, aging and quality at the same time, while the moderating effect of population urbanization is not significant. Therefore, it is necessary to optimize the coordinated governance system of regional ecological environment, accelerate the construction of industrial collaborative agglomeration, and promote the sustainable development of industry and ecology with the advantage of population structure in order to improve environmental efficiency (EE).
The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon
Authors: Aciksari Gonul , CETINKAL Gokhan , KOCAK Mehmet , Atici Adem , Celik Fatma Betul , Caliskan Mustafa 
Published: April 2021

Abstract
Purpose: In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow-flow phenomenon (CSFP) in patients undergoing elective coronary angiography for suspected coronary artery disease. Methods: This prospective study included a total of 84 CSFP patients and 83 controls with normal coronary flow, as evidenced by coronary angiography. The Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was used to measure the coronary blood flow velocity. The lipid profiles were analyzed and TG/HDL-C ratio were calculated dividing absolute TG levels by absolute HDL-C levels in peripheral blood. Results: The median TG/HDL-C ratio was higher in the CSFP group than the control group (3.4 [2.6 to 4.9] vs. 2.3 [1.8 to 3], respectively; p<0.001). The multivariate logistic regression analysis revealed that TG/HDL-C ratio was an independent predictor of CSFP (odds ratio [OR]: 1.78, 95% confidence interval [CI]: 1.59-2.32; p=0.001) and TG/HDL-C ratio was positively correlated with the TFC in the CSFP group ( r =0.311, p<0.001). The area under the receiver operating characteristic curve of TG/HDL-C for the diagnosis of CSFP was 0.73 (95% CI: 0.65-0.81; p<0.001). If a cut-off value of 2.75 was used, higher levels of TG/HDL-C ratio could predict the presence of CSFP with 72% sensitivity and 71% specificity. Conclusion: Our study results suggest that TG/HDL-C ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity.
ELK1-induced up-regulation of KIF26B promotes cell cycle progression in breast cancer
Authors: Wang SuXia , Zhang Hui , Liu HaiTing , Guo XiangYu , Ma RanRan , Zhu WenJie , Gao Peng 
Published: April 2021

Abstract
Purpose: KIF26B is a member of the kinesin superfamily that is up-regulated in various tumors, including breast cancer (BC), which can promote tumor progression. This study aimed to investigate the potential function of KIF26B in BC, and the underlying mechanisms, focusing mainly on cell proliferation. Methods: KIF26B expression was examined in BC tissue samples obtained from 99 patients. We performed MTS, EdU and flow cytometry assays to detect cell proliferation, and western blotting to measure the expression of cell cycle-related proteins in MDA-MB-231 and MDA-MB-468 cells following KIF26B knockdown. Promoter analysis was used to study the upstream regulatory mechanism of KIF26B. Results：KIF26B was upregulated in BC tissue samples. High expression of KIF26B was associated with clinicopathological parameters, such as positive lymph node metastasis, higher tumor grade and high proliferative index in BC tissue. Furthermore, knockdown of KIF26B expression inhibited MDA-MB-231 and MDA-MB-468 cell proliferation, arresting cells in the G1 phase of the cell cycle in vitro. Similarly, KIF26B silencing decreased the expression levels of Wnt, β-catenin and cell cycle-related proteins such as c-Myc, cyclin D1 and cyclin-dependent kinase 4, whilst increasing the expression of p27. Moreover, ELK1 could bind to the core promoter region of KIF26B and activate its transcription. Conclusion: KIF26B acts as an oncogene in BC that can promote development of BC by regulating multiple proteins involved in the cell cycle. ELK1 activates KIF26B transcription.
Structural basis of the complete poxvirus transcription initiation process
Authors: Fischer Utz , Grimm Clemens , Bartuli Julia , Böttcher Bettina , Szalay Aladar 
Published: April 2021

Abstract
Poxviruses express their genes in the cytoplasm of infected cells using a virus-encoded multi-subunit polymerase (vRNAP) and unique transcription factors. We present cryo-EM structures that uncover the complete transcription initiation of the poxvirus vaccinia. In the pre-initiation complex, the heterodimeric early transcription factor VETFs/l adopts an arc-like shape spanning the polymerase cleft and anchoring upstream and downstream promoter elements. VETFI emerges as a TBP-like protein that inserts asymmetrically into the DNA major groove, triggers DNA melting, ensures promoter recognition and enforces transcription directionality. The helicase VETFs fosters promoter melting and the phospho-peptide domain (PPD) of vRNAP subunit Rpo30 enables transcription initiation. An unprecedented upstream promoter scrunching mechanism assisted by the helicase NPH-I likely fosters promoter escape and transition into elongation. Our structures shed light on unique mechanisms of poxviral gene expression and aid the understanding of thus far unexplained universal principles in transcription.
Pre-compiling Parallel Algorithms for Compilers into a Network
Authors: Jemmali Mahdi , Fayez Fayez Al 
Published: April 2021

Abstract
The paper presents a novel pre-compiler approach by introducing several algorithms to solve the NP-hard problem. The paper address the challenge of transferring a large number of files from a data center (DC), encrypt it using compilers and send it through a network in the optimum time possible. Due to the high usage of big data, one compiler is not sufficient to encrypt such data in a timely manner. In order to achieve high efficiency of sending encrypted data while guarantee security and time efficiency, a new novel architecture of two parallel compilers is proposed. The running time of a given application is calculated through program instructions running time, memory allocation time and the compilation time. To have an appropriate running time it is important to choose an efficient algorithm to schedule files to compilers. Several algorithms will be coded and experimented to show the performance in time and gap.
MiRNA biomarkers and potential critical genes associated with the prognosis of gastric cancer
Authors: Chen Zhou , Xu Hao , Bai Zhongtian , Dong Shi , Zhang Jian , Zhou Wence 
Published: April 2021

Abstract
Background Dysregulated expression of miRNAs in gastric cancer (GC) is associated with tumor progression. MiRNA markers are important for the prognosis and therapeutic targeting of GC patients. Methods To detect differentially expressed miRNAs in GC from the TCGA database and predict their target genes. We downloaded RNA sequencing (RNA-seq), miRNA-seq and clinical data of GC from TCGA. Differential expression analysis of RNA-seq and miRNA-seq data was performed by R 3.6.1. MiRNAs associated with prognosis were evaluated with the Cox model, and differentially expressed miRNAs were assessed by Kaplan–Meier curve analysis. Risk factors were identified in the Cox model. Target genes of differentially expressed miRNAs were searched in three databases. GO enrichment and KEGG pathway analyses were used to evaluate the biological functions of these target genes.Results Five miRNAs (hsa-miR-135b-3p, hsa-miR-143-5p, hsa-miR-196b-3p, hsa-miR-942-3p, hsa-miR-9-3p) were related to survival. Eight target genes (AKAP12, AR, DZIP1, PCDHA11, PCDHA12, PI15, SH3BGRL and TMEM108) were closely correlated with patient overall survival (OS). Conclusion Differentially expressed miRNAs and their target genes have an important influence on the diagnosis and prognosis of GC and may be used as tumor biomarkers in further studies and as potential therapeutic targets.
How can green building development promote the efficiency of carbon emission reduction in the construction industry? ——Based on the dual perspective of industry and space
Authors: Liao Bin , Lin Li 
Published: April 2021

Abstract
Green building development plays an important role in improving the efficiency of carbon reduction in the construction industry and accelerating the construction industry to achieve carbon neutrality goals. Based on the dual perspective of "industrial upgrading and space overflow", this paper integrates the topic of "green building development to promote carbon neutrality in the construction industry" into the cross-study of industrial economics and spatial economics Using China's provincial panel data from 2008 to 2019, use the intermediary adjustment model to prove how green building development builds an internal green supply and demand system in the industry to promote the efficiency of carbon emission reduction in the construction industryand use the space panel Dubin model to discuss the green building Development affects the spatial mechanism and attenuation boundary of the construction industry's carbon emission reduction efficiency. The study found that green building development has a positive effect on the efficiency of carbon reduction in the construction industry. And there is a clear "center-peripheral pattern" between green building development and the efficiency of carbon reduction in the construction industry. At the same time, the impact of green building development on the efficiency of carbon emission reduction in the construction industry exists "industry-space" two-dimensional mechanism, from the industrial perspective, green building development can activate the construction market form a green supply and demand system by promoting the green upgrading of supporting industries and stimulating the green consumption of the market, and finally realize the overall green upgrading of the construction industry. from the spatial level, the development of regional green buildings forms a new growth pole and enhances the carbon emission reduction efficiency of the construction industry in the region through polarization effect, inhibits the carbon emission reduction efficiency of the construction industry in neighboring areas, and this spatial polarization effect also shows obvious spatial attenuation characteristics. In the 1,000 km, rangethe spillover effect is higher, while attenuation occurs outside the 1,000 km range. The results provide a theoretical basis and empirical evidence for the construction industry to improve the efficiency of carbon reduction and achieve industrial carbon neutrality.
Trauma Experiences of African Men from a Refugee Background in Western Australia: A Cross-Sectional Study
Authors: Nnadigwe Ernest Obiechina , Fisher Colleen , Wood Lisa , Martin. Karen 
Published: April 2021

Abstract
Background

As people from the African continent continue to settle in Australia, exposure of men from African refugee backgrounds to potentially traumatic events not only impact negatively on their settlement but have also been linked to increased mental health issues and family and domestic violence. This study aims to describe the prevalence and dominant forms of potentially traumatic experiences of African men from a refuge background in Western Australia.
Methods

Survey data from 421 African men from Eritrea, Ethiopia, Rwanda, Republic of Congo–Brazzaville, Sierra Leone, Democratic Republic of Congo, Liberia, Sudan and South Sudan, Burundi and Somalia were analysed using descriptive statistics.
Results

The study showed that 81% of the participants experienced at least one potentially traumatic event either in their home country or in a refugee country. However, the prevalence of potentially traumatic events in their home country ranged from 45% (Somalia) to 95% (Democratic Republic of Congo) while in refuge countries, the potentially traumatic experience prevalence ranged from 17% (Somalia) to 51% (Sudan and South Sudan). The majority of the participants (64%) experienced "War at close quarter" in their home country. In comparison, the dominant potentially traumatic experience in refuge countries was "Forced Separation" (28%). The study showed that 53% of the participants who experienced one or more potentially traumatic events in their home country also experienced one or more potentially traumatic events in the refugee country.
Conclusions

This study will provide baseline data on the prevalence and dominant forms of potentially traumatic events of African refugee men now resident in WA. The impact of potentially traumatic events should be addressed in counselling, and other interventions developed and delivered by both government and non-government agencies.