bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS
Authors: Uspenskaya Ol'ga , Kondyurova Evgeniya , Fadeeva Irina 
Published: February 2021

Objective — improvement of methods of treatment of chronic generalized periodontitis based on the analysis of the cytokine profile of patients.
Methodology. A study of 120 patients with chronic periodontitis of varying severity aged 30 to 50 years was conducted. All patients were randomized into 5 groups according to the severity of the disease and therapy. all patients received traditional anti-inflammatory therapy. In group 4, in addition to the main treatment, patients received laser therapy sessions. In group 5, patients with severe chronic periodontitis were administered remaxol along with laser therapy. Evaluation of the condition of periodontal tissues was carried out according to clinical indices. PMA, SBI, API, OHI-s, and periodontal indices were used. The serum levels of IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, and TNF-α were studied by enzyme immunoassay.
Results: In chronic generalized periodontitis of moderate and severe severity, the content of all studied proinflammatory cytokines in the blood serum increases, and more significantly in the group of patients with severe disease. At the same time, the content of anti-inflammatory mediators undergoes ambiguous changes: in group I, the content of IL-4 increases significantly, and in group II it does not change significantly. In turn, IL-10 in group I does not decrease significantly, but in group II it becomes significantly less than normal. The inclusion of laser therapy and remaxol in the complex of standard measures showed high efficiency in reducing the severity of the pathological process, which was expressed in a faster subsiding of inflammatory phenomena in periodontal tissues.
Conclusions: An increase in the content of proinflammatory cytokines in the blood serum in chronic generalized periodontitis was revealed, and more significantly in the group of patients with a severe course of the disease. At the same time, an imbalance of the system of pro-inflammatory and anti-inflammatory cytokines is registered. The use of laser therapy and remaxol in the complex treatment of CPT was the most effective.
INTEGRAL ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS AND MODERATE PERIODONTAL DISEASE
Authors: Haykin Maksim , Nesterov Aleksandr , Chigarina Svetlana , Sadykov Mukatdes , Sagirov Marsel' 
Published: February 2021

Subject of the study: to identify the relationship between the quality of life in patients with chronic generalized periodontitis and moderate periodontal disease with indicators before and after periodontal treatment.
Objective: to determine an integral assessment of the quality of life in patients with chronic generalized periodontitis and moderate periodontal disease before and after traditional periodontal treatment and with the use of new technologies.
Methodology. The study involved 120 patients aged 45-65 years with a diagnosis of chronic generalized periodontitis and moderate periodontal disease. The patients were divided into 2 groups: the main group (60 people) and the control group (60 people). The integrated assessment related to dental health was determined based on the questionnaire for determining the "dental health impact Profile OHIP-14"index. Patients of the main and control groups completed the questionnaire 3 times: before treatment, 6 and 12 months after treatment.
Results. Periodontal treatment with the use of new technologies in patients with chronic generalized periodontitis and periodontal disease of moderate severity showed an improvement in 3 main indicators of the quality of life level for the problem with food intake, the problem in communication and the problem in everyday life.
Conclusion. The use of directed tissue regeneration and the method of carboxytherapy for local treatment in patients with moderate periodontal disease in the main group compared to traditional treatment showed a significant positive dynamics of subjective signs. Reducing the clinical manifestations of diseases allowed patients to lead a full life, without experiencing the inconvenience associated with eating and communicating with people.
CLINICAL STUDIES OF THE STABILITY AND PROCESS OF OSTEOINTEGRATION OF DENTAL IMPLANTS DURING IMMEDIATE AND DELAYED IMPLANTATION
Authors: Grishin Petr , Kalinnikova Elena 
Published: February 2021

Subject. Analysis of the literature confirms that there is a definite relationship between surface microstructure, implant geometry, thread design and primary stability, and osseointegration processes. To date, a sufficient number of works on direct and delayed implantation have accumulated. However, there is not enough convincing clinical data on the quantitative assessment of primary stability at different periods of the osseointegration process. Despite the existence of experimental and clinical observations, it seems impossible to make a definite judgment about the mechanism of such a relationship. This chapter presents clinical studies of the stability and osseointegration of dental implants when performing, according to the indications, in 414 patients of direct and delayed implantation using implant systems with different surface microstructures.
Goal. Conduct clinical studies of quantitative indicators of stability and osseointegration of implants with different microstructure of the surface during direct and delayed implantation.
Methodology. For the clinical study of primary stability and the process of osseointegration during direct and delayed implantation with immediate functional loading, implant systems with different surface microstructures were used: Alfa Bio, Mis, Astra-Tech, Dentium, Ostem, Antogher, and also Humana Dental with an innovative surface. Osseointegrated implants have been used to achieve a predictable treatment outcome in clinical cases with partial or complete adentia, as well as in the presence of single, included defects.
Results. There were no significant differences in stability indicators at the time of implant placement in the alveolar bone, depending on the type of implant and the method of implantation.
Conclusions. In the process of integration of the implant into the bone tissue at a later date, the indicators of stability and osseointegration improve. The relationship between the appearance of the implant surface, primary stability and the time of its adaptation was revealed.
The relationship between individual innovativeness and belonging to different generations
Authors: Savanevičienė Asta , Statnickė Gita 
Published: February 2021

Abstract

This article, applying the cohort perspective, which views generations simply as collections of people born in a given period of time, analyses the relationship between individual innovativeness and belonging to different generations. The article provides the generation conception, gives a short overview of generational diversity, focuses on generational differences, discusses theoretical aspects of individual innovativeness and analyses individual innovativeness among the representatives of four generations: the Baby Boomers, the Generation X, the Generation Y and the Generation Z.

Keywords: Generation, the Baby Boomers, the generation X, the generation Y, the generation Z, individual innovativeness.
Identification of Phytochemicals Compound On the Ethanol Extract ‎of Banana Peel Musa Balbisiana Colla “Kepok Putih” and Musa X ‎Corniculata Lour. “Tanduk”‎
Authors: Wardati Fauchil , Fitriahani Feby , Laily Ainun ‎ Nikmati 
Published: February 2021

Indonesia is the largest banana producer in Asia and each year continues to increase its production. The number of banana production in Indonesia reached 4,177,155 tons in 2003 and increased continuously to 6,373,533 tons in 2009. The abundance of banana peel is not comparable with the utilization of a banana peel in the society which has so far not been processed much apart from being animal feed. Two types of bananas that are often processed but the peels have not been optimally utilized yet are “kepok putih” and “tanduk”. Banana peel of “kepok kuning” extract contains alkaloids, flavonoids, quinones, saponins and tannins. However, the phytochemical compounds of banana peel “kepok putih” and “tanduk” have not been widely studied. Thus, this research aims to identify the phytochemical compounds from banana peel of “kepok putih” and “tanduk”. The extraction method which used in this experiment was the maceration method using 96 % ethanol solvent. Based on the test results, which may be obtained, it is known that the ethanol extract of banana peel “kepok putih” contains flavonoids, tannins, alkaloids, while “tanduk” contains flavonoids, saponins, tannins, and alkaloids
A UNIÃO DE SACOLAS E SEMENTES VISANDO A SUSTENTABILIDADE
Authors: Eliza Maria Tenfen  , Jackson Eduardo Klug Pereira  , Rafaela Iora Stock  , Alexandra Goede DE Souza  
Published: February 2021

O uso excessivo de sacolas plásticas é assunto de preocupação mundial devido aos impactos ambientais causados pelas mesmas. Assim sendo, neste projeto foi desenvolvido um material sustentável, prático e de baixo custo: o papel reciclado, que pode substituir o plástico minimizando os danos ambientais além de melhorar a renda de famílias que trabalham com coleta e reciclagem de lixo. Foram recicladospapéis juntamente outros materiais, como fibra de bananeira e sementes de alpiste, com o intuito de melhorar as características físicas do papel e facilitar o processo de decomposição do mesmo. As sacolas foram então confeccionadas com alguns papéis selecionados.
Determination of wheat spike and spikelet architecture and grain traits using X-ray Computed Tomography imaging
Authors: Zhou Hu , Riche Andrew B. , Hawkesford Malcolm J. , Whalley William R. , Atkinson Brian S. , Sturrock Craig J. , Mooney Sacha J. 
Published: February 2021

Abstract
Background: Wheat spike architecture is a key determinant of multiple grain yield components and detailed examination of spike morphometric traits is beneficial to explain wheat grain yield and the effects of differing agronomy and genetics. However, quantification of spike morphometric traits has been very limited because it relies on time-consuming manual measurements. Results: In this study, using X-ray Computed Tomography imaging, we proposed a method to efficiently detect the 3D architecture of wheat spikes and component spikelets by clustering grains based on their Euclidean distance and relative positions. Morphometric characteristics of wheat spikelets and grains, e.g., number, size and spatial distribution along the spike can be determined. Two commercial wheat cultivars, one old, Maris Widgeon, and one modern, Siskin, were studied as examples. The average grain volume of Maris Widgeon and Siskin did not differ, but Siskin had more grains per spike and therefore greater total grain volume per spike. The spike length and spikelet number were not statistically different between the two cultivars. However, Siskin had a higher spikelet density (number of spikelets per unit spike length), with more grains and greater grain volume per spikelet than Maris Widgeon. Spatial distribution analysis revealed the number of grains, the average grain volume and the total grain volume of individual spikelets varied along the spike. Siskin had more grains and greater grain volumes per spikelet from spikelet 6, but not spikelet 1-5, compared with Maris Widgeon. The distribution of average grain volume along the spike was similar for the two wheat cultivars. Conclusion: The proposed method can efficiently extract spike, spikelet and grain morphometric traits of different wheat cultivars, which can contribute to a more detailed understanding of the sink of wheat grain yield.
The Effect of Flipped Classroom by Near Peer Education (FC by NPE) on Patient Safety Knowlege Retention in Nursing and Midwifery Students: A Solomon Four-Group Design
Authors: golaki Sima poormahdi , Kamali Farahnaz , Bagherzadeh Razieh , Hajinejad Fatemeh , Vahedparast Hakimeh 
Published: February 2021

Abstract
Introduction: Selecting an appropriate teaching method is one of the key stages in education. This study was to the effect of FC by NPE on patient safety knowledge retention in nursing and midwifery students. Methods: This randomized controlled trial, using the Solomon design, was conducted in 2019 on an 82nursing and midwifery students enrolled from Bushehr nursing and midwifery school. The samples were then allocated to four groups via block randomization. The samples in both intervention groups studied the educational content online for two weeks and subsequently attended the FC by NPE. Both control groups merely received the conventional methods. The posttest was also taken from the four study groups immediately and two months after education. Results: The posttest mean scores of knowledge in both intervention groups was homogeneous(p=0.1) and higher than those in the control groups(p<0.05). The changes in the mean scores posttest in the intervention and follow-up it did not establish a statistically significant difference between the four study groups(p=0.130,F=1.941). Conclusion: The use of the FC by NPE could increase the knowledge mean scores, but, it failed to affect knowledge retention. Given the infancy of this pedagogical approach, further studies are needed to investigate its effects on various learning outcomes.
Influence of organic manures, inorganic fertilizers and bio-fertilizers on yield and quality attributes of potato (Solanum tuberosum L.)
Authors: Congera Alexandre , M. ANJANAPPA , K.M. INDIRESH , P.K. BASAVARAJA , R. MUNIRAJAPPA 
Published: February 2021

Abstract
Studies on effect of organic, inorganic and bio-fertilizers on yield and quality attributes of potato (Solanum tuberosum L.) variety Kufri Jyoti, comprising of 10 different treatments using randomized complete block design with three replications were conducted at Post Graduate Centre, University of Horticultural Sciences, Campus, Gandhi Krishi Vignana Kendra, Bangalore during Rabi 2011. Application of 50% RDF + 50% FYM + Azotobacter + Phosphobacteria (T7) showed significantly maximum number of tubers per plant (7.87), tuber yield per plant (363.33 g plant− 1) and tuber yield per hectare (34.13 t ha− 1). This treatment also produced maximum tuber dry matter (21.67%), starch content (78.20%) non-reducing sugars (0.84%) and total sugars (1.74%) which were on par with T3, T4 and T6 during rabi 2011.
Psychosocial Responses and Preparedness During Initial Phase of&nbsp;COVID-19 Pandemic Among Nurses Working Different Hospitals of Eastern Nepal: A Pre-Experimental Mixed Method Approach
Authors: Pokharel Rita , Shah Tara , Lama Sami , Karki Anjula , Shrestha Erina 
Published: February 2021

Abstract
Background: Most documented studies have focused on mental health status of Health care workers during the pandemic but there are very few studies, focusing on mitigation of mental health problems among nurses. There is an increasingly urgent need to understand mental health impact of COVID-19 and address these impacts through research. Objective: To study psychosocial responses and preparedness for covid-19 and to assess effectiveness of intervention among nurses working in COVID-19 hospitals of eastern Nepal. Methods: Prospective explanatory mixed-method study was conducted among 278 nurses by purposive sampling. Self administered questionnaire method was used for data collection. Psychosocial strengthening program was delivered and effectiveness was assessed after 4-5 weeks of intervention among 192 nurses. DASS-21, Composite measure of personal financial burden scales and in-depth interview guide were used to collect data. Chi-square and paired t test, and Pearson's correlation test were used at 95% confidence interval. Results: Mild depression was found among 13.7%, moderate and severe depression were found among 9.4% and 1.1% respectively. Similarly, mild, moderate, severe and extremely severe anxiety were found among 21.2%, 8.6%, 3.2%, 2.2% respectively. Stress was mild among 9%, moderate 1.4% and severe in 0.7% of the participants. Lack of PPE and fear of transmitting infection to family were found as frequent causes of problems during in-depth interview. Mean Scores of Depression, Anxiety and Stress were significantly decreased after receiving psychosocial strengthening program (p=<0.001 for each). Majority of the participants (92.8%) had made infection prevention preparation and 11.2% of the participants had high financial worry.Conclusion: Anxiety and depression were common problems though having adequate preparedness to deal with COVID-19. Psychosocial strengthening program was effective in reducing the problems.
Prevalence of Drug-Drug Interactions in Sarcoma Patients: Key Role of the Pharmacist Integration for Toxicity Risk Management
Authors: Bellesoeur Audrey , Gataa Ithar , Jouinot Anne , Mershati Sarah El , Piketty Anne Catherine , Tlemsani Camille , Balakirouchenane David , Monribot Anthia , Vidal Michel , Batista Rui , Percin Sixtine De , Villeminey Clementine , Alexandre Jerome , Goldwasser Francois , Blanchet Benoit , Boudou-Rouquette pascaline , Thomas-Schoemann Audrey 
Published: February 2021

Abstract
Background: The risk of drug drug interactions (DDI) has become a major issue in cancer patient care. However, data in sarcoma patients are scarce. We aimed to evaluate the frequency of DDI with antitumor treatments, identify the risk factors for DDI and evaluate the impact of a pharmacist evaluation before anticancer treatment. Patients and Methods: We performed a retrospective review of consecutive sarcoma patients starting chemotherapy (CT) or Tyrosine kinase inhibitor (TKI). A pharmacist performed medication reconciliation and established an early toxicity risk assessment. Potential DDI with antitumor drugs were identified using Micromedex electronic software. Results: One hundred twenty-two soft-tissue and 80 bone sarcoma patients (103 males, median age 50 years,) were included before chemotherapy (86%) or tyrosine kinase inhibitor (14%). The median number of medications was 3; 34 patients (22% of patients with medication reconciliation) reported complementary medicine use. 37 potential DDI classified as major, were identified (12% of the 243 pre-therapeutic assessments). In multivariate analysis, TKI (p<0.0001), proton pump inhibitor (p=0.026) and antidepressant (p<0.001) were identified as risk factors of DDI (p<0.02). Marital status (p=0.003) was the single factor associated with complementary medicine use. A pharmacist performed 157 medication reconciliation and made 71 interventions among 59 patients (37%). In multivariate analysis, factors associated with pharmacist intervention were: complementary medicines (p= 0.004), drugs number (p=0.005) and treatment with TKI (p=0.0002)Conclusions: Clinical interventions on DDI are more frequently required among sarcoma patients treated with TKI than CT. Multidisciplinary risk assessment including a medication reconciliation by a pharmacist could be crucial to prevent DDI with TKI.
Primary Intracranial Malignant Melanomas in Solitary Type: A Tertiary Center Experience&nbsp;
Authors: Zheng Yun-Cong , Huang Yen-Min , Yeh Kun-Yun , Chen Pin-Yuan , Hsieh Tsan-Yu , Hsu Li-Sung , Wu Chiao-En 
Published: February 2021

Abstract
BackgroundSolitary type primary intracranial malignant melanoma (PIMM) is extremely rare but fatal. The optimal treatment algorithm according to clinical relevance of symptoms and outcomes is unclear. This series emphasized the prognostic factors of solitary PIMM and established the treatment algorithm for this rare disease.MethodsPatients with solitary PIMMs were pathologically verified and treated with neurosurgical tumor resection. All solitary PIMMs recruited at our institute received multidisciplinary team care. We analyzed the clinical findings and prognostic factors. ResultsThe study cohort included 10 patients. PIMMs in solitary type impacted middle-aged populations with male predominance in Taiwan. Most patients (80%) presented a single tumor initially. Six patients had progressed to multiplicity after the initial treatment. Rates of tumor bleeding and leptomeningeal metastasis (LM) are high in solitary PIMMs. Patients who had gross-total resection (GTR) had better survival than those who had incomplete resection, with median overall survival (OS) rates of 170.4 months vs. 5.23 months (p = 0.004). Multiplicity, eloquent area involvement, initial tumor bleeding, LM, hydrocephalus, and Karnofsky Performance Score<80 at diagnosis were associated with negative outcomes in progression-free survival and OS. Adjuvant radiotherapy for patients who had LM and for those who cannot undergo grossly total tumor removal resulted in a good outcome.ConclusionsGTR demonstrated better outcomes for solitary PIMM. For recurrent tumors, aggressively repeated surgical resection remained beneficial for selected cases. Adjuvant radiotherapy was a treatment option for LM following operation. We proposed a possible treatment algorithm for solitary PIMM.
Evaluating Implication of Long Term Watershed Development on Plant Diversity Dynamics in Maybar Sub -Watershed, South Wello Zone, Ethiopia
Authors: Taye Tilahun 
Published: February 2021

Abstract
Long term watershed management in Ethiopia was evaluated starting from the 1980s, in different agro-ecologies. A study was conducted to investigate the implication of long term watershed management on the plant diversity dynamics in Maybar sub watershed, North-eastern Amhara, Ethiopia. Plant diversity data was collected through focus group discussion with key informants, transect walks and field observation. Each plants could been categorized under their nature of plantation such as cultivated crop, fruit and Vegetables, cultivated tree, shrub and herb, grass, wild or semi-wild tree and shrub and Other (weed, Herb, Bush…), and the existence also classified as past and current condition. Then, analysis was done by SPSS16.0 statistical software. The results showed that while two types of indigenous plant species currently disappeared, newly introduced plant species had been increased by 14.41% from the previous plant species diversity. Cultivated trees, shrub and herb, fruit and vegetables and grass species relative proportion have been increased by 52.98%, 18.18%, and 1.8% respectively. In contrast, plants categorized under cultivated crops, wild or semi-wild trees and shrubs and others (weed, wild herb, bush) has been decreased by 25.31%, 18.31%, and 11.37% respectively. Therefore, long term watershed development has a positive impact on plant diversity improvement.