bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-Term Hemodynamic Performance And Clinical Results of 19-mm st. Jude Medical Regent Valve In Patients With Small Aortic Annulus Undergoing Dual Valve Replacement: A Retrospective Study
Authors: Wei Dong , Zhang Shijie , Cheng Xianfeng , Huang Junjie , Cheng Shanghao , Yun Yan , Zhao Diming , Li Jinzhang , Wu Zezhong , Liu Yanwu , Shen Hechen , Ma Huibo , Zhang Haizhou , Wang Zhengjun , Zou Chengwei , Ma Xiaochun 
Published: October 2021

Abstract
Background: The prosthesis selection in patients with small aortic annulus undergoing aortic valve replacement (AVR) has always been a challenge, especially in dual valve replacement (DVR, combined aortic and mitral valve replacement). The present study aimed to analyze early-term hemodynamic parameters of 19-mm St. Jude Medical Regent ( SJMR19 ) valve in patients with small aortic annulus undergoing DVR. Methods: Between January 2015 to December 2020, 54 patients with small aortic annulus who underwent DVR were divided into two groups: SJMR19 valve group (n=30) and 21-mm mechanical (M21) valve group (n=24). The perioperative and early-term hemodynamic data were collected and analyzed. Results: A significant difference in terms of maximum transaortic flow velocity (Vav max), maximum transaortic pressure gradient (PGav max), left ventricular mass index (LVMi) and left ventricular mass (LVM) was observed postoperatively in both groups. The postoperative left ventricular ejection fraction (LVEF) was significantly higher while the LVM and LVMi was evidently decreased in the SJMR19 group, compared with the M21 group. In order to confirm the influencing factors on postoperative LVEF, a multiple linear regression analysis model was established by including all candidate variables and the implanted valve type was identified in the multivariate analysis as an independent predictor for postoperative LVEF. Conclusions: The postoperative cardiac function and hemodynamic parameters was improved both in the SJMR19 and M21 groups. The postoperative LVEF, LVM and LVMi were better in the SJMR19 group compared with those of the M21 group. And the implanted valve type might possess the predictive value of postoperative LVEF in patients with small aortic annulus undergoing DVR.
Plasma Glial Fibrillary Acidic Protein and Neurofilament-Light for the Diagnostic and Prognostic Evaluation of Frontotemporal Dementia
Authors: Zhu Nuole , Santos-Santos Miguel , Illán-Gala Ignacio , Montal Victor , Estellés Teresa , Barroeta Isabel , Altuna Miren , Arranz Javier , Muñoz Laia , Belbin Olivia , Sala Isabel , Sanchez-Saudinos Maria Belén , Subirana Andrea , Videla Laura , Blesa Rafael , Clarimón Jordi , Carmona-Iragui Maria , Fortea Juan , Lleó Alberto , Alcolea Daniel 
Published: October 2021

Abstract
Background: Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. The Study of Glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may be helpful to better understand the different neurodegenerative diseases. We investigated the diagnostic performance of plasma GFAP (pGFAP), plasma neurofilament (pNfL) and their combination in frontotemporal dementia (FTD) and Alzheimer’s disease (AD). We studied their clinical utility in predicting disease progression. Methods: We measured pGFAP and pNfL concentrations in 72 FTD, 56 AD and 83 cognitively normal participants (CN) using Single Molecule Array technology. Of 211 participants, 199 had CSF and 122 had MRI. We compared cross-sectional biomarker levels between groups, studied their diagnostic performance and assessed correlation with CSF biomarkers, cognitive performance and cortical thickness. The prognostic performance was investigated analyzing cognitive decline between group comparisons by tertile. Results: Unlike pNfL, which was increased similarly in both clinical groups, pGFAP was increased in FTD but lower than in AD (all p<0.01). The combination of both plasma markers improved the diagnostic performance to discriminate FTD from AD (combination AUC 0.78; pGFAP AUC 0.7; pNfL AUC 0.61, all p<0.05). In FTD, pGFAP correlated with cognition, CSF and plasma NfL, and cortical thickness (all p<0.05). The higher tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD (1.40 points annually, HR 3.82, p<0.005) and AD (1.20 points annually, HR 2.26, p<0.005).Conclusions: pGFAP and pNfL differed in FTD and AD, their combination could be useful to distinguish the two diseases. pGFAP could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.
Patent Ductus Arteriosus Device or Surgical Closure: the Role of Charity Missions Where the Resources Are Limited
Authors: Elsheikh Abdallah Elamin , Hassan Salah Eldin M.E , Nureldayim Abdel Mahmoud , Ahmed Mohamed Alamin , Hussein Sabir Taha , allah.Eljack Moh.Mah.Fadel 
Published: October 2021

Abstract
Objectives

To compare the different methods of treatment of patent ductus arteriosus (PDA), and evaluate the role of charity missions in availing the expensive devices for needy patients where the resources are limited.
Background

The role of surgery is gradually being taken over by catheter intervention, however the cost in not affordable to most of our patients. Charity organizations are helping limited resource countries by availing the devices.
Methods

All paediatrics patent ductus arteriosus (PDA) patients presenting to Medani Heart Centre (MHC) in a 6-year period were included in this study. The study included 337 patients. 283 were treated by catheter intervention group (A) and 54 were treated surgically group (B), 22 patients were referred for surgery from the catheterization laboratory, and 32 were treated when there was no visiting teams.
Results

A total of 337 patients were included in this study, 32 were treated surgically by the local surgical teams. Out of remaining 305 patients 283 were found suitable for catheterization intervention, and were treated successfully, 22(%7) were having other congenital anomalies or PDA not suitable for intervention and were referred to surgery. 54 patients were treated by surgical ligation, 22 were referred from the intervention group and 32 were treated surgically when there were no visiting delegates and patients’ condition dictate urgent intervention, with good results. Devices were provided by charity organizations and delivered by the visiting teams, the choice of device depends on the availability.
Conclusions

Surgery remains a good modality of treatment were the resources are scares, however a number of charity organizations are offering these expensive devices for countries of low and middle income making it possible for the poor patients to have such treatment. The results of both treatments are excellent
Aspect ratio is associated with recanalization after coiling of unruptured intracranial aneurysms
Authors: Hara Takeshi , Satow Tetsu , Hamano Eika , Hashimura Naoki , Sumi Masatake , Ikedo Taichi , Ohta Tsuyoshi , Takahashi Jun C , Kataoka Hiroharu 
Published: October 2021

Abstract
Background

The rate of recanalization after coil embolization for unruptured intracranial aneurysms (UIAs) is reported to occur around 11.3-49%. Aim of this study is to investigated the factors that influence the recanalization after coil embolization for unruptured intracranial aneurysms (UIAs) in our institution.
Methods

We retrospectively investigated 307 UIAs in 296 patients treated at our institution between April 2004 and December 2016. The stent used cases were excluded. Cerebral angiography and 3D TOF MRA were used for evaluation of the postoperative occlusion status. Volume embolization ratio (VER), aneurysmal size, neck width, and aspect ratio (AR) were compared between the recanalized and non-recanalized groups.
Results

The mean follow-up period ranged from 6 to 172 months (mean: 79.0±39.8 months). Recanalization was noted in 87 (28.3%) aneurysms, and 19 (6.2%) aneurysms required retreatment. There was no aneurysmal rupture during the follow-up period. Univariate analysis showed that the aneurysm size (p < 0.001), neck width (p = 0.002), AR (p = 0.003), and VER (p = 0.027) were associated with recanalization. Multivariate logistic regression analysis showed that the AR (p =0.004) and VER (p =0.015) were significant predictors of recanalization.
Conclusions

In our study, AR and VER were significant predictors of recanalization after coil embolization for UIAs.
Physiochemical effect on the microgroove microstructure in microcutting of pure copper
Authors: Zhang Jiayi 
Published: October 2021

Abstract
Physiochemical effect on the machining of pure copper is studied via microstructure characterization on the cross-sectioned microgroove. An obvious decreased cutting force and thrust force were obtained with the application of surfactant. The surface roughness of microgroove with physiochemical effect is 12 nm, and that without physiochemical effect is 17 nm. The average grain size of the medium-affected sample is 67.9 µm within the microgroove zone, and that of the medium-free sample is 48.3 µm within the microgroove zone, moreover, the grain size of medium-free microgroove near the microgroove surface is larger than that far away from the microgroove surface. Additionally, the grain orientations of medium-affected cross-sectioned surface present anisotropy, while that of medium-free cross-sectioned surface are towards {101} direction. Based on the calculation and analysis of geometrically necessary dislocation, it can be inferred that the induced stress and temperature in the sample with physiochemical effect are higher than that without physiochemical effect, which can provide enough driving energy for recrystallization.
Using exhalation dynamics to evaluate PEEP levels in COVID-19 related ARDS
Authors: Depta Filip 
Published: October 2021

Abstract
Background

We hypothesized that measured expiratory time constant (TauE) could be a bedside parameter for evaluation of PEEP settings in mechanically ventilated COVID-19 patients during pressure-controlled ventilation (PCV) mode. TauE is an easily measured parameter to assess lung physiology, even in non-homogeneous lungs including COVID-19 ARDS.
Methods

A prospective study was conducted including consecutively admitted adults (n = 16) with COVID-19 related ARDS requiring mechanical ventilation. Ventilator settings for all patients included: PCV, RR 18/min, constant inspiratory pressure 14 cmH2O, I:E ratio 1:1.5 and FiO2 1.0. Escalating levels of PEEP (0 to 18 cmH2O) were applied and measured TauE and expiratory tidal volume (Vte) recorded. Next, a new parameter, TauE Index (TEI) was calculated (TEI = TauE * Vte) at each PEEP level in prone (n = 29) or supine (n = 24) positions. TEI maps were created to graphically show changes in individual physiology with PEEP. The PEEP setting with the highest TEI corresponded to the highest product of TauE and Vte and was considered the most suitable PEEP. Most suitable PEEP range was calculated as ± 10% from highest TEI.
Results

Two groups of patterns were observed in the TEI maps, recruitable (R) (75%) and non-recruitable (NR) (25%). In R group, the most suitable PEEP and PEEP range was 9±3 cmH2O and 6-12 cmH2O for prone position and 11±3 cmH2O and 7-13 cmH2O for supine position. In NR group, the most suitable PEEP and PEEP range was 7±3 cmH2O and 0-8 cmH2O for prone position and 4±2 cmH2O and 0-7 cmH2O for supine position, respectively. The R group showed significantly higher suitable PEEP (p<0.01) and PEEP ranges (p<0.01) than NR group. 45% of measurements resulted in most suitable PEEP being significantly different between the positions (p < 0.01).
Conclusions

Based on TEI mapping, responses to PEEP were easily measured. There was wide variation in patient responses to PEEP that indicate the need for personalized evaluation.
Association between serum uric acid level and carotid atherosclerosis and metabolic syndrome in patients with type 2 diabetes mellitus
Authors: li wei , Wang Yan , Ouyang Shengrong , Li Mengdi , Liu Rui , Zhang Yuqi , Liu Xiaojun , Li Tianfang , Liu Shengyun 
Published: October 2021

Abstract
Background

Serum uric acid (SUA) is associated with many cardiovascular risk factors, such as metabolic syndrome (MetS) and subclinical atherosclerosis. However, the relationship of SUA with carotid atherosclerosis remains controversial. We aimed to investigate whether elevated SUA levels are associated with a high risk of carotid atherosclerosis and MetS in patients with type 2 diabetes mellitus (T2DM).
Methods

This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness (CIMT) and carotid artery plaques (CAP) were measured via Doppler ultrasound.
Results

Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54–5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis.
Conclusions

In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.
An Efficient Discrete Wavelet Transform Based Hybrid Image Watermarking Algorithm Using Human Visual Model
Authors: V Sundhararaj , B Meenakshipriya , P Nirmala Devi 
Published: October 2021

Abstract
More than ever with growing of multimedia technology, the digital data are exchanged in the internet, which can be duplicated by unauthorized users. To avoid this problem the watermarking technology has brought this paper. Performance improvement with compare to existing algorithm is obtained by proposing a new watermarking algorithm based on Human Visual Model (HVM) and Discrete Wavelet Transform (DWT) for securing the digital data and copyright protection. DWT is applied to the input image and at each level of DWT sub bands to embed a watermark image in selected coefficients of the sub band. HVM integrate the weight factor effect of human visualization by considering into the eye’s vision is less sensitivity area, depending on brightness, frequency band and texture areas of the image sub band. In the proposed approach robustly and imperceptibly, DWT and HVM are used for obtainable weight factor, according to human eye perceptual and to determine the optimal strength at which the threshold to embedding reaches the perceptual invisibility of watermarked image to various attacks. Performance is evaluated such as Peak Signal to Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM) and Quality Index (QI) is used to evaluate and achieve the imperceptible watermarked image. Results of PSNR values of hybrid image watermarking are between 49.73db to 36.24db. Experimental results show that our hybrid image watermarking process has enhanced robustness and displays the effectiveness of presenting images watermarking system.
Directions for improving adaptive management efficiency of manufacturing pharmaceutical companies
Authors: Sahaidak-Nikitiuk Rita , Holybtsova Karyna , Demchenko Nataliya , Nikitiuk Vitalii 
Published: October 2021

The aim of the article is to analyze the existing problems of adaptive management of manufacturing pharmaceutical companies and the development of methodological support for their management.
Materials and methods. The research used methods of theoretical generalization, analysis and synthesis, synergetic approach and expert survey.
120 people were involved in the expert survey, divided into four groups: representatives of pharmaceutical manufacturing enterprises (30 people); representatives of pharmaceutical higher education institutions (30 people); pharmaceutical distributors representing wholesale companies (30 people); end users (30 people).
Results. The article considers scientific and methodological approaches to improving adaptive management in the direction of forming competitive advantages of manufacturing pharmaceutical companies, the practical implementation of which requires business entities determination, flexibility and adequacy in the formation of modern management strategies and tactical planning and operational tasks of production, economic and commercial activities. There are external and internal factors influencing the formation of competitive advantages of the business entity. As the internal factors we include: organizational and legal form, and business entity organizational structure; the level of scientific and technical development of production; level of education and qualification of staff; business image of the enterprise; financial reputation of the enterprise. However, no less influence on the formation of competitive advantages of the management of manufacturing pharmaceutical companies have external factors, which, in contrast to internal, are not controlled by the entity: the state of the pharmaceutical market; technologies; workforce; scientific and technical development; etc.
Conclusions. The directions of increasing the adaptive management efficiency are determined and it is concluded that the main criterion of efficiency is the quality of pharmaceutical products and the quality of management decisions in economic risks.
Comparison of the effects of co-transplantation of bone marrow hematopoietic stem cells and thymic multipotent stromal cells on the immune system of mice depending on methods
Authors: Demchenko Dariia , Nikolskiy Igor , Nikolskaya Valentyna , Pelykh Natalia 
Published: October 2021

Physical interaction of multipotent stromal cells (MSCs) and hematopoietic stem cells (HSCs) is a modern approach to effective and focused changes in the properties of HSCs. Resulting of those contact interaction is significant activation of cells with following immune system restoration.
The purpose of the study is to investigate the effect of co-transplantation of bone marrow hematopoietic stem cells (HSCs) and thymic multipotent stromal cells (MSCs) separately and as a union of cells on regeneration of the murine immune system, damaged by cyclophosphamide.
MSCs were obtained from thymuses of C57BL mice using explant technique. Bone marrow cells (BMCs) were obtained by flushing out the femur with a nutrient medium. BMCs were cocultivated for 2 hours on the monolayer of thymus-derived MSCs. The immune deficiency of mice was modelled by the treatment with cyclophosphamide (CP). After that, the cells were co-transplanted in two methods (separately into different the retroorbital sinus and as a union after co-cultivation) and the parameters of the immune system were evaluated. It was shown, that separate co-transplantation of BMCs and thymus-derived MSCs is associated with the restoration of the number of bone marrow cells, thymus, spleen and lymph nodes with an increase in the proliferation index of lymph node cells by 1.4 times compared to control. It normalized the previous reduced concentration of hemoglobin and hematocrit in the blood. Co-transplantation had a suppressive effect on the blast transformation reaction, induced by phytohemagglutinin, by 4.3 times, but showed a stimulating effect on DTHR response by 1.6 times compared to control.
Co-transplantation of the union of BMCs and MSCs is associated with the restoration of the number of bone marrow cells, spleen and lymph nodes. The level of spontaneous apoptosis of lymph node cells significantly increased by 3.3 times compared to control. It had not effect on hematological parameters, but is activated to impact the immune system. Thus, as a result of cells union administration showed normalization of the bactericidal activity of peritoneal macrophages, unlike the separate co-transplantation. This cells graft had a suppressive effect on the number of antibody-producing cells in the spleen by 4.2 times compared to control.
Previous co-cultivation and contact interaction of cells change the properties of cell graft. The effect of co-transplantation of BMCs and thymic MSCs is not a simple additive effect of cells. It is acquiring the features typical to certain cell types, and the expression of new characteristics. We assume this phenomenon as a result development of complex cells cooperative processes in vivo and in vitro
An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review
Authors: Kumar Amit , Siwach Ankit , Verma Prabhakar 
Published: October 2021

:
Pyrimidine and its derivatives are a very important class of heterocyclic compounds that
show interesting applications in the field of medicinal chemistry. Pyrimidine not only plays an important
role as an organic reaction intermediate but also has a wide range of interesting biological activities
viz. antibacterial, antifungal, anticancer, anti-inflammatory, antiviral, and antiprotozoal activities,
etc. Numerous methods are available for the formation of pyrimidine derivatives that have been
reported in the literature. The advantage of pyrimidine as a starting material for different therapeutically
potent derivatives has given momentum to this research. This review aims to report the new
work on the synthesis of marketed drugs which consist pyrimidine moiety.