bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial residential segregation and economic disparity jointly exacerbate COVID‐19 fatality in large American cities
Authors: Yu Qinggang , Salvador Cristina E. , Melani Irene , Berg Martha K. , Neblett Enrique W. , Kitayama Shinobu 
Published: February 2021

AbstractThe disproportionately high rates of both infections and deaths among racial and ethnic minorities (especially Blacks and Hispanics) in the United States during the COVID‐19 pandemic are consistent with the conclusion that structural inequality can produce lethal consequences. However, the nature of this structural inequality in relation to COVID‐19 is poorly understood. Here, we hypothesized that two structural features, racial residential segregation and income inequality, of metropolitan areas in the United States have contributed to health‐compromising conditions, which, in turn, have increased COVID‐19 fatalities; moreover, that these two features, when combined, may be particularly lethal. To test this hypothesis, we examined the growth rate of confirmed COVID‐19 cases and deaths in an early 30‐day period of the outbreak in the counties located in each of the 100 largest metropolitan areas in the United States. The growth curves for cases and deaths were steeper in counties located in metropolitan areas where Blacks and Hispanics are residentially segregated from Whites. Moreover, the effect of racial residential segregation was augmented by income inequality within each county. These data strongly suggest that racial and economic disparities have caused a greater death toll during the current pandemic. We draw policy implications for making virus‐resilient cities free from such consequences.
Ups and downs of belemnite diversity in the Early Jurassic of Western Tethys
Authors: Neige Pascal , Weis Robert , Fara Emmanuel 
Published: February 2021

AbstractAlthough belemnites form a major clade of extinct cephalopods, the early stage of their diversification remains poorly known in time and space. Here we investigate the first diversification episodes of belemnites (order Belemnitida) using a new species‐level database encompassing the Hettangian–Aalenian interval (Early Jurassic – earliest Middle Jurassic) and covering the Western Tethys. Rarefied richness shows a four‐fold increase from the Planorbis chronozone to the Ibex chronozone, a strong decrease between the Margaritatus and Spinatum chronozones, followed by a drop in the Spinatum–Serpentinum interval that is coeval with the second‐order Toarcian biological crisis. The Bifrons chronozone records a high richness that departs significantly from those of the surrounding chronozones. A last richness peak in the Dispansum chronozone precedes a decrease towards the Aalenian. Biogeographical analyses do not reveal any clear large‐scale provincialism for belemnites, in sharp contrast with ammonoids. Such a long‐term homogeneous spatial distribution of belemnites is probably due to: (1) the relatively poorly‐documented fossil record of belemnites, especially in Mediterranean localities; and (2) contrasted dispersal abilities of belemnites compared to ammonoids over the studied time interval.
Isoprene and β‐caryophyllene confer plant resistance via different plant internal signalling pathways
Authors: Frank Lena , Wenig Marion , Ghirardo Andrea , van der Krol Alexander , Vlot A. Corina , Schnitzler Jörg‐Peter , Rosenkranz Maaria 
Published: February 2021

AbstractIsoprene and other terpenoids are important biogenic volatile organic compounds in terms of atmospheric chemistry. Isoprene can aid plant performance under abiotic stresses, but the fundamental biological reasons for the high emissions are not completely understood. Here, we provide evidence of a previously unrecognized ecological function for isoprene and for the sesquiterpene, ß‐caryophyllene. We show that isoprene and ß‐caryophyllene act as core components of plant signalling networks, inducing resistance against microbial pathogens in neighbouring plants. We challenged Arabidopsis thaliana with Pseudomonas syringae, after exposure to pure volatile terpenoids or to volatile emissions of transformed poplar or Arabidopsis plants. The data suggest that isoprene induces a defence response in receiver plants that is similar to that elicited by monoterpenes and depended on salicylic acid (SA) signalling. In contrast, the sesquiterpene, ß‐caryophyllene, induced resistance via jasmonic acid (JA)‐signalling. The experiments in an open environment show that natural biological emissions are enough to induce resistance in neighbouring Arabidopsis. Our results show that both isoprene and ß‐caryophyllene function as allelochemical components in complex plant signalling networks. Knowledge of this system may be used to boost plant immunity against microbial pathogens in various crop management schemes.
The relations of reflective and intuitive thinking styles with task performance: A meta‐analysis
Authors: Alaybek Balca , Wang Yi , Dalal Reeshad S. , Dubrow Samantha , Boemerman Louis S. G. 
Published: February 2021

AbstractWe conducted a meta‐analysis to examine the relations of individual differences in reflective (or rational) and intuitive thinking styles with workplace task performance. We meta‐analyzed 113 effect sizes from 71 independent samples (N = 11,713). Results indicate that reflective thinking style has a positive and non‐zero meta‐analytic relation with task performance (ρ = .213). This positive relation is stronger in environments characterized by higher task complexity, greater importance of creativity and innovation for work tasks, and higher time pressure associated with work tasks. Intuitive thinking style, conversely, has a very small but positive meta‐analytic relation with task performance (ρ = .051), and this relation is stronger in environments characterized by higher task complexity. Finally, incremental validity analyses reveal that reflective thinking style explains unique variance in task performance, beyond conscientiousness and intelligence (general mental ability). Overall, this meta‐analysis demonstrates that reflective thinking style is an important antecedent to task performance.
Photosynthesis on the Ultrafast Time Scale within the Confinements of Quantum Nanostructured Photosystems
Authors: Sordillo Laura A. , Budansky Yury , Alfano Robert R. 
Published: February 2021

AbstractFundamental information on the behavior of excited chlorophyll molecules packed within the confinements of nanosized photosystems I and II, following absorption of light, is presented. Using a 100 femtosecond laser with nanojoule (nJ) pulse energy and a one picosecond streak camera, we observed the light emitted from the nanostructured photosystems without oscillations or hops. The fluorescent exponential decay profiles and high efficiency within the nanostructure suggest that light coherently drains out as a unit. This implies that "quantumness" is linked to quantum confinement on the nano scale.
The Influence of Residents’ Resilience on the Recovery in the Torrential Rain in Western Japan in 2018
Authors: Ohtomo Shoji , Kimura Reo 
Published: February 2021

AbstractIn 2018 torrential rain caused serious human suffering and damage to property in western Japan. Following such disasters, the investigation of residents’ subsequent recovery process is important to determine the support required in affected areas and disaster risk management. This study examines the effects of psychological resilience on residents’ life recovery following the torrential rain. We conducted a web survey with 1,000 residents in 13 districts of Hiroshima prefecture and 6 districts of Okayama prefecture that suffered the most damage caused by the torrential rain. The survey used the “recovery calendar” approach to assess residents’ life recovery from the disaster. Results indicated that residents who had suffered relatively little damage began to recover during the “disaster utopia” phase up to 2 months after the disaster. However, residents who had suffered serious damage began to recover during the “reentry to everyday life” phase up to 6 months after the disaster. Moreover, older residents or residents with strong psychological resilience who suffered serious damage were likely to recover sooner than those with weaker psychological resilience. Therefore, this study indicates the importance of an approach to disaster recovery according to the level of damage, phased time period, and psychological resilience.
Cohort profile: Dementia in the Registry of Senior Australians
Authors: Cations Monica , Lang Catherine E , Ward Stephanie A , Crotty Maria , Whitehead Craig , Maddison John , Inacio Maria 
Published: February 2021

PurposeClinical quality registries (CQRs) are being established in many countries to monitor, benchmark, and report on the quality of dementia care over time. Case ascertainment can be challenging given that diagnosis occurs in a variety of settings. The Registry of Senior Australians (ROSA) includes a large cohort of people with dementia from all Australian states and territories identified using routinely collected aged care assessment data. In ROSA, assessment data are linked to information about aged and health service use, medicine dispensing, hospitalisations and the National Death Index. The ROSA dementia cohort was established to capture people for the Australian dementia CQR currently in development who may not be identified elsewhere.ParticipantsThere were 373 695 people with dementia identified in aged care assessments from 2008 to 2016. Cross-sectional analysis from the time of cohort entry (e.g. when first identified with dementia on an aged care assessment) indicates that individuals were 84.1 years old on average, and 63.1% were female. More than 44% were first identified at entry to permanent residential aged care. The cohort recorded more severe cognitive impairment at entry than other international dementia registries.Findings to dateThe cohort has so far been used to demonstrate a declining prevalence of dementia in individuals entering the aged care sector, examine trends in psychotropic medicine prescribing, and to examine the impact of dementia on aged care service use and outcomes.Future plansThe ROSA dementia cohort will be updated periodically and is a powerful resource both on its own and as a contributor to the Australian dementia CQR. Integration of the ROSA dementia cohort with the dementia CQR will ensure that people with dementia using aged care services can benefit from the ongoing monitoring and benchmarking of care that a registry can provide.
Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design
Authors: Mckay Pamela G , Walker Helen , Martin Colin R , Fleming Mick 
Published: February 2021

ObjectiveTo explore the relationship between symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM). The hypothesis predicated that there would be no significant differences between the group’s symptom experience.DesignA quasiexperimental design. Structural equation modelling (SEM) and invariance testing.ParticipantsMales (M) and females (F) >16 with a confirmed diagnosis of CFS/ME or FM by a general practitioner or specialist. CFS/ME (n=101, F: n=86, M: n=15, mean (M) age M=45.5 years). FM (n=107, F: n=95, M: n=12, M=47.2 years).Outcome measuresDiagnostic criteria: the American Centers for Disease Control and Prevention (CDC) for CFS/ME and the American College of Rheumatology (ACR) criteria for FM. Additional symptom questionnaires measuring: pain, sleep quality, fatigue, quality of life, anxiety and depression, locus of control and self-esteem.ResultsInvariance was confirmed with the exception of the American CDC Symptom Inventory, Fibromyalgia Impact Questionnaire and Hospital Anxiety and Depression Scale (p<0.05) based on five questions. Consequently, it was erroneous to conclude differences. Therefore, the Syndrome Model was created. SEM could not have tested the ACR previously, as it comprised a single data point. Thus, it was combined with these three questionnaires, increasing the data points, to create this new measurable model. Results confirmed no significant differences between groups (p=0.07 (p<0.05)).ConclusionParticipants responded in a similar manner to the questionnaire, confirming the same symptom experience. It is important to consider this in context with differing criteria and management guidelines, as this may influence diagnosis and the trajectory of patient’s management. With the biomedical cause currently unclear, it is the symptom experience and the impact on quality of life that is important. These findings are meaningful for patients, clinicians and policy development and support the requirement for future research.
Implementation of a multicomponent intervention sign to reduce delirium in orthopaedic inpatients (MIND-ORIENT): a quality improvement project
Authors: Reppas-Rindlisbacher Christina , Siddhpuria Shailee , Wong Eric Kai-Chung , Lee Justin Yusen , Gabor Christopher , Curkovic Alexandra , Khalili Yasmin , Mavrak Caroline , De Freitas Sandra , Eshak Kristeen , Patterson Christopher 
Published: February 2021

Delirium is a serious and common condition that leads to significant adverse health outcomes for hospitalised older adults. It occurs in 30%–55% of patients with hip fractures and is one of the most common postoperative complications in older adults undergoing orthopaedic surgery. Multicomponent, non-pharmacological interventions can reduce delirium incidence by up to 30% but are often challenging to implement as part of routine care. We identified a gap in the delivery of non-pharmacological interventions on an orthopaedic unit. This project aimed to implement a bedside sign on an orthopaedic unit to reduce the occurrence of delirium by prompting staff to use multicomponent evidence-based delirium prevention strategies for at-risk older adults. Quality improvement methods were used to integrate and optimise the use of a bedside ‘delirium prevention’ sign on an orthopaedic unit.The sign was implemented in four target rooms and sign completion rates increased from 47% to 83% (95% CI 71.7% to 94.9%; p<0.001) over a 10-month period. The sign did not have a significant impact on delirium prevalence. The mean Confusion Assessment Method (CAM)+ rate during the baseline period was 8% with an absolute increase in the intervention period to 11.4% (95% CI 7.2% to 15.8%; p=0.31). There were no significant shifts or trends in the run chart for the proportion of patients with CAM+ scores over time. The sign was well received by staff, who reported it was a worthwhile use of time and prompted use of non-pharmacological interventions. This quality improvement project successfully integrated a novel, low-cost, feasible and evidence-based approach into routine clinical care to support staff to deliver non-pharmacological interventions. Given the increased pressures on front-line staff in hospital, tools that reduce cognitive load at the bedside are important to consider when caring for a vulnerable older adult patient population.
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells
Authors: Olazagoitia-Garmendia Ane , Zhang Linda , Mera Paula , Godbout Julie K , Sebastian-DelaCruz Maialen , Garcia-Santisteban Iraia , Mendoza Luis Manuel , Huerta Alain , Irastorza Iñaki , Bhagat Govind , Green Peter H , Herrero Laura , Serra Dolors , Rodriguez Jose Antonio , Verdu Elena F , He Chuan , Bilbao Jose Ramon , Castellanos-Rubio Ainara 
Published: February 2021

ObjectivesCoeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten free diet. Human leucocyte antigen (HLA) genes and several non-HLA regions have been associated with the genetic susceptibility to CD, but their role in the pathogenesis of the disease is still essentially unknown, making it complicated to develop much needed non-dietary treatments. Here, we describe the functional involvement of a CD-associated single-nucleotide polymorphism (SNP) located in the 5’UTR of XPO1 in the inflammatory environment characteristic of the coeliac intestinal epithelium.DesignThe function of the CD-associated SNP was investigated using an intestinal cell line heterozygous for the SNP, N6-methyladenosine (m6A)-related knock-out and HLA-DQ2 mice, and human samples from patients with CD.ResultsIndividuals harbouring the risk allele had higher m6A methylation in the 5’UTR of XPO1 RNA, rendering greater XPO1 protein amounts that led to downstream nuclear factor kappa B (NFkB) activity and subsequent inflammation. Furthermore, gluten exposure increased overall m6A methylation in humans as well as in in vitro and in vivo models.ConclusionWe identify a novel m6A-XPO1-NFkB pathway that is activated in CD patients. The findings will prompt the development of new therapeutic approaches directed at m6A proteins and XPO1, a target under evaluation for the treatment of intestinal disorders.
STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment
Authors: Chelvanambi Manoj , Fecek Ronald J , Taylor Jennifer L , Storkus Walter J 
Published: February 2021

BackgroundThe degree of immune infiltration in tumors, especially CD8+ T cells, greatly impacts patient disease course and response to interventional immunotherapy. Enhancement of tumor infiltrating lymphocyte (TIL) is a critical element of efficacious therapy and one that may be achieved via administration of agents that promote tumor vascular normalization (VN) and/or induce the development of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).MethodsLow-dose stimulator of interferon genes (STING) agonist ADU S-100 (5 µg/mouse) was delivered intratumorally to established subcutaneous B16.F10 melanomas on days 10, 14 and 17 post-tumor inoculation. Treated and control tumors were isolated at various time points to assess transcriptional changes associated with VN and TLS formation via quantitative PCR (qPCR), with corollary immune cell composition changes in isolated tissues determined using flow cytometry and immunofluorescence microscopy. In vitro assays were performed on CD11c+ BMDCs treated with 2.5 µg/mL ADU S-100 or CD11c+ DCs isolated from tumor digests and associated transcriptional changes analyzed via qPCR or profiled using DNA microarrays. For T cell repertoireβ-CDR3 analyses, T cell CDR3 was sequenced from gDNA isolated from splenocytes and enzymatically digested tumors.ResultsWe report that activation of STING within the TME leads to slowed melanoma growth in association with increased production of antiangiogenic factors including Tnfsf15 (Vegi) and Cxcl10, and TLS-inducing factors including Ccl19, Ccl21, Lta, Ltb and Light. Therapeutic responses resulting from intratumoral STING activation were characterized by improved VN, enhanced tumor infiltration by CD8+ T cells and CD11c+ DCs and local TLS neogenesis, all of which were dependent on host expression of STING. Consistent with a central role for DC in TLS formation, ADU S-100-activated mCD11c+ DCs also exhibited upregulated expression of TLS promoting factors including lymphotoxin-α (LTA), interleukin (IL)-36, inflammatory chemokines and type I interferons in vitro and in vivo. TLS formation in ADU S-100-treated mice was associated with the development of a highly oligoclonal TIL repertoire enriched in expanded T cell clonotypes unique to the TME and not detected in the periphery.ConclusionsOur data support the premise that i.t. delivery of low-dose STING agonist promotes VN and a proinflammatory TME supportive of TLS formation, enrichment in the TIL repertoire and tumor growth control.
The incidence of pelvic fractures with traumatic lower limb amputation in modern warfare due to improvised explosive devices
Authors: Cross AM , Davis C , Penn-Barwell J , Taylor DM , De Mello WF , Matthews JJ 
Published: February 2021

AbstractAimsA frequently-seen injury pattern in current military experience is traumatic lower limb amputation as a result of improvised explosive devices (IEDs). This injury can coexist with fractures involving the pelvic ring. This study aims to assess the frequency of concomitant pelvic fracture in IED-related lower limb amputation.MethodsA retrospective analysis of the trauma charts, medical notes, and digital imaging was undertaken for all patients arriving at the Emergency Department at the UK military field hospital in Camp Bastion, Afghanistan, with a traumatic lower limb amputation in the six months between September 2009 and April 2010, in order to determine the incidence of associated pelvic ring fractures.ResultsOf 77 consecutive patients with traumatic lower limb amputations, 17 (22%) had an associated pelvic fracture (eleven with displaced pelvic ring fractures, five undisplaced fractures and one acetabular fracture). Unilateral amputees (n=31) had a 10% incidence of associated pelvic fracture, whilst 30 % of bilateral amputees (n=46) had a concurrent pelvic fracture. However, in bilateral, trans-femoral amputations (n=28) the incidence of pelvic fracture was 39%.ConclusionsThe study demonstrates a high incidence of pelvic fractures in patients with traumatic lower limb amputations, supporting the routine pre-hospital application of pelvic binders in this patient group.
Leishmaniasis and its relevance to UK Armed Forces
Authors: Preedy HC , Bailey MS 
Published: February 2021

AbstractLeishmaniasis is an infectious disease caused byLeishmaniaprotozoa, transmitted by the bite of phlebotomine sandflies. It causes a spectrum of clinical syndromes, of which the most common are cutaneous and visceral leishmaniasis. Clinical presentation is highly variable and is dependent on multiple factors, such asLeishmaniaspecies and patient characteristics (including immune competence). The relationship between these variables is poorly understood, and there is no single, evidence-based treatment for the disease. Currently management focuses on identification of the species, but this requires specialist tests which are often unavailable, particularly on military operations. Leishmaniasis is of particular relevance to military medical personnel as it is endemic in many tropical and sub-tropical regions of the world, including Belize, Iraq and Afghanistan where UK Armed Forces may be deployed. It can present a potentially serious threat to military personnel deployed in endemic areas due to the possibility of long-term sequelae of infection.
The management of the acutely swollen ankle
Authors: Howes RJ , Wood AM , Calder A , Cowan H , Burrows H 
Published: February 2021

AbstractPatients presenting with an acutely swollen ankle are common in both the military and civilian settings. Accurate diagnosis is vital, as there are various potentially serious causes. This article aims to review the common causes of an acutely swollen ankle, as well as the rarer causes, with their significant consequences.