bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal model for the Mayo Clinical Score and its sub-components in patients with ulcerative colitis
Authors: Kawakatsu Sonoko , Zhu Rui , Zhang Wenhui , Tang Meina T. , Lu Tong , Quartino Angelica L. , Kågedal Matts 
Published: October 2021

AbstractClinical trials in patients with ulcerative colitis (UC) face the challenge of high and variable placebo response rates. The Mayo Clinical Score (MCS) is used widely as the primary endpoint in clinical trials to describe the clinical status of patients with UC. The MCS is comprised of four subscores, each scored 0, 1, 2 and 3: rectal bleeding (RB), stool frequency (SF), physician’s global assessment (PGA), and endoscopy (ENDO) subscore. Excluding the PGA subscore gives the modified MCS. Quantitative insight on the placebo response, and its impact on the components of the MCS over time, can better inform clinical trial design and interpretation. Longitudinal modeling of the MCS, and the modified MCS, can be challenging due to complex clinical trial design, population heterogeneity, and limited assessments for the ENDO subscore. The current study pooled patient-level placebo/standard of care (SoC) arm data from five clinical trials in the TransCelerate database to develop a longitudinal placebo response model that describes the MCS over time in patients with UC. MCS subscores were modeled using proportional odds models, and the removal of patients from the placebo/SoC arm, or “dropout”, was modeled using logistic regression models. The subscore and dropout models were linked to allow for the prediction of the MCS and the modified MCS. Stepwise covariate modeling identified prior exposure to TNF-α antagonists as a statistically significant predictor on the RB + SF subscore. Patients with prior exposure to TNF-α antagonists had higher post-baseline RB + SF subscores than naive patients.
Dynamic perspectives on technology transfer: introduction to the special section
Authors: Barberá-Tomás David , Azagra-Caro Joaquín M. , D’Este Pablo 
Published: October 2021

AbstractTheoretical frameworks acknowledge the dynamic and evolving nature of technology transfer. However, there is a scarcity of empirical work in the field incorporating a dynamic and longitudinal perspective. Several literature reviews call for technology transfer research agendas to include longitudinal studies. In response to such calls, this special section comprises selected contributions to the 2018 Technology Transfer Society (T2S) Conference which address this gap from different angles. The three qualitative and three quantitative works chosen contain research questions and methodologies related to dynamic aspects of technology transfer. We argue that historical and processual studies offer additional new directions.
Association Between Age of Achieving Gross Motor Development Milestones During Infancy and Body Fat Percentage at 6 to 7 Years of Age
Authors: Aoyama Tomoko , Hikihara Yuki , Watanabe Masashi , Wakabayashi Hitoshi , Hanawa Satoshi , Omi Naomi , Takimoto Hidemi , Tanaka Shigeho 
Published: October 2021

Abstract
Objectives
The later achievement of gross motor milestones during infancy is associated with adiposity in early childhood. However, the associations between gross motor development and adiposity after entering primary school are unclear. This study examined the associations between the ages at which six gross motor milestones were achieved and adiposity during early school years.

Methods
This retrospective study was conducted in 2012 and 2013. Data were collected from 225 first-grade primary school children (mean age, 6.9 years; 39% girls). Adiposity was assessed using dual-energy X-ray absorptiometry and expressed as body fat percentage. Data describing the ages of achieving six gross motor milestones (holding head up, sitting, crawling, standing supported, walking supported, and independent walking) were obtained from the Maternal and Child Health Handbooks.

Results
Mean body fat percentage was 21.7%. Multiple linear regression analyses revealed that later ages of achieving crawling (p < .001 [95% confidence interval: 0.33–1.16]), standing supported (p < .001 [95% confidence interval: 0.64–1.65]), and walking supported [p = .013 (95% confidence interval: 0.13–1.07)] were associated with increased fat. However, the ages of achieving holding head up (p = .053), sitting (p = .175), and independent walking (p = .736) were not statistically significant.

Conclusions
Achieving crawling, standing supported, and walking supported later predict increased body fat when aged 6–7 years. The practice of observing gross motor milestone achievements may allow early targeted interventions to optimize body composition before beginning school and thereby, potentially prevent childhood obesity.
Analysing Multimodal Texts in Science—a Social Semiotic Perspective
Authors: Wanselin Hanna , Danielsson Kristina , Wikman Susanne 
Published: October 2021

AbstractTeaching and learning in science disciplines are dependent on multimodal communication. Earlier research implies that students may be challenged when trying to interpret and use different semiotic resources. There have been calls for extensive frameworks that enable analysis of multimodal texts in science education. In this study, we combine analytical tools deriving from social semiotics, including systemic functional linguistics (SFL), where the ideational, interpersonal, and textual metafunctions are central. In regard to other modes than writing—and to analyse how textual resources are combined—we build on aspects highlighted in research on multimodality. The aim of this study is to uncover how such a framework can provide researchers and teachers with insights into the ways in which various aspects of the content in multimodal texts are communicated through different semiotic resources. Furthermore, we aim to explore how different text resources interact and, finally, how the students, or authors of teaching resources, position themselves in relation to the subject. Data consist of one student text and one teaching resource text, both comprising drawn and written elements in combination with symbols. Our analyses of the student text suggest that the proposed framework can provide insights into students’ content knowledge and, hence, how construction of multimodal texts may be a useful tool for formative assessment. When it comes to teaching resources, the framework may be a useful tool for teachers when choosing resources, particularly in relation to students’ possibilities of meaning making when engaging with such texts, but also, as a basis for classroom discussions.
Who Speaks for Science?
Authors: Allchin Douglas 
Published: October 2021

AbstractIronically, flat-Earthers, anti-vaxxers, and climate change naysayers trust in science. Unfortunately, they trust thewrongscience. That conundrum lies at the heart of scientific literacy in an age of well-funded commercial and ideological interests and overwhelming digital information. The core question for the citizen-consumer is not philosophically “why trust science?” (Oreskes 2019) but sociologically “who speaks for science?” Teachers can help students learn how to navigate the treacherous territory of inevitably mediated communication and the vulnerabilities of epistemic dependence. Students need to understand the role of science communication practices (media literacy) and the roles of credibility, expertise and honesty and the deceptive strategies used by imitators of science to seem like credible voices for science.
(E-) Valuative Metrics as a Contested Field: A Comparative Analysis of the Altmetrics- and the Leiden Manifesto
Authors: Leckert Max 
Published: October 2021

AbstractThis article comparatively analyzes two manifestos in the field of quantitative science evaluation, the Altmetrics Manifesto (AM) and the Leiden Manifesto (LM). It employs perspectives from the Sociology of (E-) Valuation to make sense of highly visible critiques that organize the current discourse. Four motifs can be reconstructed from the manifestos’ valuation strategies. The AM criticizes theconfinednessof established evaluation practices and pledges for anexpansionof quantitative research evaluation. The LM denounces theproliferationof ill-applied research metrics and calls for anenclosureof metric research assessment. It can be shown that these motifs are organized diametrically: The two manifestos represent opposed positions in a critical discourse on (e-) valuative metrics. They manifest quantitative science evaluation as a contested field.
Social Impact Assessment: A Systematic Review of Literature
Authors: Alomoto William , Niñerola Angels , Pié Laia 
Published: October 2021

AbstractMeasuring, analyzing, and evaluating social, environmental, and economic impact is crucial to aligning the sustainable development strategies of international organizations, governments, and businesses. In this sense, society has been a determining factor exerting pressure for urgent solutions. The main objective of this paper is to provide an exhaustive analysis of the literature about the tools for measuring social impact and their evolution over the last 50 years. The search was conducted in the main academic databases (Scopus and Web of Science), where 924 articles were found from 1969 to 2020 related to the topic. The results of the quantitative analysis show that 71% of the publications were in the last ten years and the most productive countries were the USA and the United Kingdom. The relational analysis identifies 4 large clusters that fragment the literature into different subfields. The most used keywords are linked to the term "Social" in measurement methods, new concepts, and participants. This article contributes to the literature by giving the researcher an insight into the current state of art, trends, categories within the field, and future lines of research.
The Global Financial Crisis and Healthcare Inequality in Japan
Authors: Sakoda Sayaka , Tamura Masaoki , Wakutsu Naohiko 
Published: October 2021

AbstractThe aim of this study is to clarify whether health-care inequality in Japan widens during a depression, even though Japan has a universal health-care system. To this end, we investigate the time-series fluctuations in health-care expenditure inequalities in Japan for the period 2008–2017, which includes the period during which the global financial crisis affected Japan. We construct an economy-wide inequality index comparing the actual health-care expenditure at various income levels (low, middle and high) against the estimated health-care needs. The findings of the study are as follows. First, the rich (the top 20% income class) spend far more than their estimated needs on health care, whereas the poor (bottom 20%) spend far less. Second, during the global financial crisis, health-care inequality especially among the working generation became greater in Japan, mainly because not only the low-income class but also the middle-income class (the bottom 30–60%) was unable to pay for health care.
The general-relativistic case for super-substantivalism
Authors: Duerr Patrick M. , Calosi Claudio 
Published: October 2021

AbstractSuper-substantivalism (of the type we’ll consider) roughly comprises two core tenets: (1) the physical properties which we attribute to matter (e.g. charge or mass) can be attributed to spacetimedirectly, with no need for matter as an extraneous carrier “on top of” spacetime; (2) spacetime is more fundamental than (ontologically prior to) matter. In the present paper, we revisit a recent argument in favour of super-substantivalism, based on General Relativity. A critique is offered that highlights the difference between (various accounts of) fundamentality and (various forms of) ontological dependence. This affords a metaphysically more perspicuous view of what super-substantivalism’s tenetsactuallyassert, and how it may be defended. We tentatively propose a re-formulation of the original argument that not only seems to apply to all classical physics, but also chimes with a standard interpretation of spacetime theories in the philosophy of physics.
‘Disfigurations’ of Democracy? Pareto, Mosca and the Challenge of ‘Elite Theory’
Authors: Jackson Robert P. 
Published: October 2021

AbstractConsidering recent re-assessments of Pareto and Mosca, I discuss whether these thinkers’ socio-political orientations contribute to the ‘disfiguration’ of democracy (in: Urbinati, Democracy disfigured: opinion, truth, and the people, Harvard, Cambridge, MA, 2014) or provide a resource for the renewal of democratic institutions. Femia (Pareto and political theory, Routledge, Abingdon, 2006) presents Pareto as being in the “Machiavellian tradition of sceptical liberalism,” revealing the liberal potential of Pareto’s realist political theory. Finocchiaro (Beyond right and left, Yale, New Haven, London, 1999) ameliorates the conservative consequences of Mosca’s thought by reinterpreting him as a ‘democratic elitist,’ who holds a conception of political liberty “as a relationship such that authority flows from the masses to the elites.” Highlighting the significance of internal tensions within each thinker’s work foregrounded by these readings, between the causal primacy of psychic states and the ‘mutual dependence’ of social factors (Pareto), and between the elite principle and ‘balanced pluralism’ (Mosca), I ask whether the ‘sceptical liberal’ Pareto or the ‘democratic elitist’ Mosca elude Urbinati’s unpolitical, populist and plebiscitarian ‘disfigurations’ of democracy.
SD-Net: joint surgical gesture recognition and skill assessment
Authors: Zhang Jinglu , Nie Yinyu , Lyu Yao , Yang Xiaosong , Chang Jian , Zhang Jian Jun 
Published: October 2021

Abstract
Purpose
Surgical gesture recognition has been an essential task for providing intraoperative context-aware assistance and scheduling clinical resources. However, previous methods present limitations in catching long-range temporal information, and many of them require additional sensors. To address these challenges, we propose a symmetric dilated network, namely SD-Net, to jointly recognize surgical gestures and assess surgical skill levels only using RGB surgical video sequences.

Methods
We utilize symmetric 1D temporal dilated convolution layers to hierarchically capture gesture clues under different receptive fields such that features in different time span can be aggregated. In addition, a self-attention network is bridged in the middle to calculate the global frame-to-frame relativity.

Results
We evaluate our method on a robotic suturing task from the JIGSAWS dataset. The gesture recognition task largely outperforms the state of the arts on the frame-wise accuracy up to $$\sim $$
∼
6 points and the F1@50 score $$\sim $$
∼
8 points. We also keep the 100% predicted accuracy for the skill assessment task using LOSO validation scheme.

Conclusion
The results indicate that our architecture is able to obtain representative surgical video features by extensively considering the spatial, temporal and relational context from raw video input. Furthermore, the better performance in multi-task learning implies that surgical skill assessment has a complementary effects to gesture recognition task.
The incidence of lung cancer in Northern Ireland: 1991–1992
Authors: Wilkinson Pauline , MacMahon Joe , MacKenzie Gilbert 
Published: October 2021

Abstract
Introduction
Lung cancer is the leading cause of cancer deaths in many Western countries, but its incidence has never been studied in Northern Ireland.

Aims
Accordingly, the present study was mounted to determine, for the first time, the incidence of the condition in Northern Ireland and to compare the findings with other regions in the British Isles.

Methods
A notification study of the incidence of lung cancer (ICD 162) was conducted in Northern Ireland during 1991/1992. Notifications from 6 sources were computerised and linked. Incident cases were identified and analysed in relation to Age, Sex and Geographical region—Northern Ireland, England and Wales, Scotland and the Republic of Ireland.

Results
Some 900 incident cases of lung cancer were identified. The incidence rate per 100,000 population was found to be 57.04. Mortality underestimated incidence by 12.5%. ($$p<0.05$$

p
<
0.05

). The male to female incidence ratio was 2.1: 1, and this ratio was similar in other regions, except Scotland, where the ratio was 1.7:1. The null hypothesis of a common incidence distribution across regions was formally rejected. A variety of models were fitted and a model in which the log-odds on incidence was a quadratic function of age fitted most of the regional data.

Conclusions
Northern Ireland had the lowest incidence of lung cancer in the UK, but its overall rate was still 40% higher than that observed in the Republic of Ireland which had the lowest rate in the British Isles. Across regions, the pattern of incidence by age and sex was complicated, but a linear logistic model fitted all of the Irish data and the female data in Scotland, satisfactorily.
Reasons for dropping out of internet-based problem gambling treatment, and the process of recovery – a qualitative assessment
Authors: Nilsson Anders , Simonsson Olivia , Hellner Clara 
Published: October 2021

AbstractProblem gambling (PG) is a condition affecting the economy, mental health, and relationships of both the individuals with gambling problems, and concerned significant others (CSOs). While PG is treatable, few individuals with gambling problems seek treatment, and many drop out of treatment. This qualitative study aims to investigate a) the reasons for individuals with gambling problems to drop-out from Internet-based PG treatment, and b) what individuals with gambling problems and CSOs find helpful and unhelpful processes in PG recovery. A total of 16 participants (8 individuals with gambling problems and 8 CSOs) who had participated in an Internet-based PG treatment were interviewed over the telephone in a semi-structured interview. The interviews were analyzed using thematic analysis. Drop-out from treatment was one aspect of an overarching theme identified as unstable path to recovery, where alternating periods of progress and setbacks delineate several aspects of PG. Relapses, negative emotions, and changing life circumstances were identified to separately, and in combination, contribute to drop-out. Drop-outs were also explained by participants’ experiences of a reduced need for treatment. Openness and a support from CSOs and peers were identified as themes important for recovery. The results suggest that PG treatments should consider the emotional state, and comorbidities of the patients, in order to reduce drop-out and improve chances of recovery.
Glass-based pigments in painting: smalt blue and lead–tin yellow type II
Authors: Cavallo Giovanni , Riccardi Maria Pia 
Published: October 2021

Abstract Glass-based pigments have an important role in the panorama of artistic production due to the fact that their manufacturing processes involve a combination of different skills and understanding, and they have a role in disciplines ranging from glass technology to metallurgy, from glazed ceramic to stone imitation and from vitreous mosaic tesserae to painting materials. The main goal of this manuscript is to present a critical review of the literature relating to blue smalt and “yellow glass” (lead–tin yellow type II) pigments: presenting their historical background, the analytical protocol, the processes of alteration and decay and finally tracing issues. Several case studies analyzed by the authors will be presented. Particular attention was devoted to the correlation between micro-textural features and decay processes affecting the studied pigments, though the widespread heterogeneity of the analyzed materials and the variability of the artistic techniques in which the pigments were used as well as the effect of the relevant (micro-)environmental conditions dictate a cautious approach. These studies are presented in the context of information about the chain of production, the selection of the raw materials and relevant provenance studies.
Identification of Workers at Increased Risk of Infection During a COVID-19 Outbreak in a Meat Processing Plant, France, May 2020
Authors: Mallet Yoann , Pivette Mathilde , Revest Matthieu , Angot Elisabeth , Valence Marion , Dupin Clarisse , Picard Nicolas , Brelivet Guillaume , Seyler Thomas , Ballet Stéphany , Le Tertre Alain , Guillois Yvonnick 
Published: October 2021

AbstractOn 13 May 2020, a COVID-19 cluster was detected in a French processing plant. Infected workers were described. The associations between the SARS-CoV-2 infection and the socio-demographic and occupational characteristics were assessed in order to implement risk management measures targeting workers at increased risk of contamination. Workers were tested by RT-PCR from samples taken during screening campaigns. Workers who tested positive were isolated and their contacts were quarantined. Workers were described and associations with the SARS-CoV-2 infection were assessed through risk ratios using multivariable Poisson regression. Of the 1347 workers, 87.5% were tested: 140 cases were identified; 4 were hospitalised, including 2 admitted to intensive care. In the company, the cluster remained limited to deboning and cutting activities. The attack rate was 11.9% in the company, reaching 16.6% in the cutting department. Being an employee of a subcontractor significantly increased the risk of infection by 2.98 [1.81–4.99]. In the cutting department, an association with virus infection was found for a group of non-French speaking workers from the same Eastern European country (RR = 2.67 [1.76–4.05]). They shared accommodation or carpooled more frequently than the other cases. The outbreak investigation revealed a significantly increased risk of SARS-CoV-2 infection for workers of subcontractors and some foreign-born workers. There are many such populations in meat processing plants; the observed associations and the ways in which these workers are contaminated need to be confirmed by further work. Prevention campaigns should now target these workers. Environmental risk factors in the workplace setting remain to be clarified.
Update on the source of phenoloxidase activity in the hemolymph of kuruma prawn Marsupenaeus japonicus
Authors: Masuda Taro 
Published: October 2021

AbstractCrustacean phenoloxidase (PO) and hemocyanin (Hc) are classified as type 3 copper proteins. PO catalyzes the oxidation of mono- and di-phenol compounds, which is the rate-limiting step of melanization, while Hc generally functions as a dioxygen-transporting protein in the hemolymph of arthropods. To date, many studies have shown PO activity in Hc, which is inspired by their structural similarity. Here, the source of PO activity in crustaceans was re-examined by purifying Hc and PO exclusively from the hemolymph of kuruma prawn. The conventional procedure for the preparation of arthropod Hc, which includes precipitation of Hc by ultracentrifugation and subsequent purification by size exclusion chromatography, was not able to completely remove hemolymph-type PO from Hc. In contrast, fractionation with 50% saturation of ammonium sulfate and subsequent hydrophobic chromatography yielded sufficiently pure Hc, which contained no detectable PO protein and virtually no PO enzymatic activity. These results indicate that the main source of PO activity in the hemolymph of kuruma prawn is hemolymph-type PO and that the improved purification method of Hc is preferable for evaluating the PO activity of Hc.