bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultimate Load Measuring System for Fixation of Soft Tissue to Bone
Authors: Fujii Tatsuya , Tateura Makoto , Ogawa Masato , Ozeki Satoru 
Published: September 2021

Background: The initial ultimate load for graft fixation is one of the essential factors in the reconstruction of lateral ankle ligaments. Several anchoring devices have been developed to fix the substitute ligament into the bone. A fair comparison of these fixation methods warrant a reproducible examination system. The purpose of this study was to make an experimental animal model and to compare the initial ultimate loads of 3 graft fixation methods, including the use of EndoButton (EB), interference screw (IFS), and a novel socket anchoring (SA) technique. Methods: Porcine calcaneus bones and 5-mm-wide split bovine Achilles tendons were used as fixation bases and graft materials, respectively. Both ends were ﬁrmly sutured side-by-side, using the circumferential ligation technique as a double-strand substitute that was 45 mm in length. Porcine calcanei with similar characteristics to adult human calcanei were mounted on a tensile testing machine, and substitutes were fixed into bones using the 3 fixation methods. A polyester tape was passed through the tendon loop and connected to a crosshead jig of the testing machine. The initial ultimate loads were measured in 15 specimens for each fixation method to simulate a lateral ankle ligament (LAL) injury. Results: The ultimate loads (ULs) were 223.6 ± 52.7 N for EB, 229.7 ± 39.7 N for SA, and 208.8 ± 65.3 N for IFS. No statistically significant difference was observed among the 3 groups ( P = .571). All failures occurred at the bone–ligament substitute interface. Conclusion: The initial ULs in all 3 fixation methods were sufficient for clinical usage. These values were larger than the UL of the anterior talofibular ligament; however, these were smaller than the UL of the calcaneofibular ligament. Clinical Relevance: In an experimental animal model, ULs for SA, EB, and IFS techniques showed no significant difference. All failures were observed in the fixation site of the calcaneus and were overwhelmingly related to suture fixation failure.
Influence of the implementation of a multidisciplinary consultation program on adherence to the first ever course of oral antineoplastic treatment in patients with cancer
Authors: Feral Aurelie , Boone Mathieu , Lucas Virginie , Bihan Céline , Belhout Mohamed , Chauffert Bruno , Lenglet Aurelie 
Published: September 2021

Purpose To evaluate adherence (as measured by the medication possession ratio) to the first ever course of oral antineoplasic treatment in cancer patients before and after the implementation of a multidisciplinary consultation program (involving an oncologist, a pharmacist, and a nurse) and to investigate the program's impact on adverse events and drug-related problems. Patients and Methods In a retrospective single-center study, we compared the medication possession ratio 2 months after treatment initiation in a control group (before multidisciplinary consultation program implementation) versus an interventional group (after multidisciplinary consultation program implementation). Results Two months after oral antineoplasic treatment initiation, the mean ± standard deviation medication possession ratio did not differ significantly when comparing the interventional (multidisciplinary consultation program) group ( n = 33; 0.99 ± 0.06) with the control group ( n = 64; 0.94 ± 0.16) ( p = 0.062). Patients in the multidisciplinary consultation program group had fewer adverse events in general (41, vs 109 in the control group; p = 0.048) and digestive adverse events in particular (6 vs 29, respectively; p = 0.007). A total of 53 and 40 drug-related problems were identified in the control and multidisciplinary consultation program groups, respectively ( p = 0.074). Conclusions Implementation of an multidisciplinary consultation program was not associated with a significant difference in drug adherence (as assessed by the medication possession ratio), which was good before and after implementation. The multidisciplinary consultation program was associated with a lower incidence of adverse events.
A successful initiation of treatment of Hodgkin's lymphoma with adriamycin-bleomycin-vinblastine-dacarbazine dose reduction in a patient with fulminant hepatic failure and co-infection with human immunodeficiency virus and hepatitis B
Authors: Veeraballi Sindhusha , Chan Kok H , Slim Jihad , Shaaban Hamid S , Guron Gunwant 
Published: September 2021

Introduction Hodgkin lymphoma is a highly curable lymphoproliferative malignancy with an overall relative survival rate of 87.4%. It is characterized by multinucleated Reed–Sternberg cells which are mostly derived from B cells in the germinal center. Case report We present a case of a 40-year-old gentleman with acquired immunodeficiency syndrome who presented with Stage 4b Hodgkin lymphoma complicated with fulminant hepatic failure and direct hyperbilirubinemia. The initial presentation of Hodgkin lymphoma as cholestatic jaundice is extremely rare. Management and outcome Though the survival rate with chemotherapy is high, the fulminant hepatic failure made the situation challenging with the use of chemotherapeutic regimens that require hepatic excretion. He received dose reduced adriamycin-bleomycin-vinblastine-dacarbazine regimen [doxorubicin 12.5 mg (6.75 mg/m2), bleomycin 18 units (10 units/m2), vinblastine 3 mg (1.5 mg/m2), dacarbazine 380 mg (190 mg/m2)] as well as bictegravir/emtricitabine/tenofovir alafenamide since admission for treatment of human immunodeficiency virus and hepatitis B. He started responding with the first cycle of dose reduced adriamycin-bleomycin-vinblastine-dacarbazine regimen with bilirubin levels trended down and normalized as well as his clinical condition improved. He received the full dose of adriamycin-bleomycin-vinblastine-dacarbazine on day 15. Discussion Our case report emphasizes that the early usage of dose reduced adriamycin-bleomycin-vinblastine-dacarbazine regimen can restore hepatic function and can achieve improvement in hepatic function allowing the delivery of full-dose chemotherapy.
Nurses’ knowledge and experience related to short peripheral venous catheter extravasation
Authors: Atay Selma , Üzen Cura Şengül , Efil Sevda 
Published: September 2021

Background: The majority of hospitalized patients receive a Peripheral Venous Catheter (PVC) in the course of their treatment. Extravasation injury is a serious complication of intravenous treatment. Objective: This cross-sectional survey designed study aims to investigate nurses’ knowledge and experience related to short peripheral venous catheter extravasation. Method: The study sample included 145 nurses working in a university hospital in the west of Turkey. A questionnaire developed in accordance with the literature was used for data collection. The data were assessed by frequency and proportions. Results: Of the nurses included in this study, 26.2% reported they had experienced extravasation injury in a patient; 74.5% said they had received no instruction in the management of extravasation during their in-service training program; and 85.5% stated they did not keep a record of extravasation. 89.7% of the nurses reported infused medications as a cause of extravasation, and 81.4% reported catheter sites as a cause. Among the medications reported by the nurses as causing extravasation: 89.7% reported contrast agents; 84.8% TPN solutions; 71.0% cytotoxic agents; and 65.1% mannitol. The symptoms of extravasation reported by nurses included: swelling (97.9%), redness (97.2%), pain (92.4%), rise in temperature (65.5%), and ulceration (60.0%). In responding to the occurrence of extravasation, interventions reported by the nurses included: stopping the flow of fluid (98.6%), elevation (89.7%), cold application (76.6%), and aspiration of drug (40.7%). Conclusion: Based on these results, it is recommended that guidelines are developed for the management of extravasation, that periodic in-service training programs are provided and that observational studies are carried out into the administration of vesicant drugs.
Social workers’ attitudes toward reparations for African American descendants
Authors: Jones V. Nikki , McElderry Cathy G , Conner Laneshia R 
Published: September 2021

Summary Reparations for African Americans in its most basic form amounts to a concerted effort to repair damages from hundreds of years of exploitation and mistreatment toward people of African ancestry. The legacy of chattel slavery manifests in ongoing racial injustices, including gross disparities in health and wealth. The injustices resultant from the system of chattel slavery and its sequela have not been formally addressed by the U.S. government. As a profession, social work is dedicated to the empowerment of marginalized communities and upholds a mandate to advocate for social justice. As such, this study examines social workers’ attitudes toward reparations for African American descendants. Descriptive analyses and analyses of association were used to interpret survey data. Findings A convenience sample of 186 social work professionals and students participated in this exploratory study. Findings of the study suggest that a majority of social workers agree with reparations (73%) as a strategy to redress present-day disparities. Additionally, a majority of the participants agree that reparations can begin to repair racial inequality. Applications This groundbreaking study lays the foundation for future research about social workers’ perceptions and support of reparations. Furthermore, results of this study should encourage social work organizations to infuse scientific research in formulating position statements and advocacy on the issue of reparations.
Online Dance Therapy for People With Parkinson’s Disease: Feasibility and Impact on Consumer Engagement
Authors: Morris Meg E. , Slade Susan C. , Wittwer Joanne E. , Blackberry Irene , Haines Simon , Hackney Madeleine E. , McConvey Victor B. 
Published: September 2021

Background Therapeutic dancing can be beneficial for people living with Parkinson’s disease (PD), yet community-based classes can be difficult to access. Objective To evaluate the feasibility and impact of online therapeutic dancing classes for people in the early to mid-stages of PD. Methods Co-produced with people living with PD, physiotherapists, dance teachers and the local PD association, the ‘ParkinDANCE’ program was adapted to enable online delivery during the COVID-19 pandemic. Participants completed 8 one-hour sessions of online therapeutic dancing. Each person was assigned their own dance teacher and together they selected music for the classes. A mixed-methods design enabled analysis of feasibility and impact. Feasibility was quantified by attendance and adverse events. Impact was determined from individual narratives pertaining to consumer experiences and engagement, analysed with qualitative methods through a phenomenological lens. Results Attendance was high, with people attending 100% sessions. There were no adverse events. Impact was illustrated by the key themes from the in-depth interviews: (i) a sense of achievement, enjoyment and mastery occurred with online dance; (ii) project co-design facilitated participant engagement; (iii) dance instructor capabilities, knowledge and skills facilitated positive outcomes; (iv) music choices were key; and (v) participants were able to quickly adapt to online delivery with support and resources. Conclusions Online dance therapy was safe, feasible and perceived to be of benefit in this sample of early adopters. During the pandemic, it was a viable form of structured physical activity. For the future, online dance may afford benefits to health, well-being and social engagement.
Urinary incontinence secondary to a suspected congenital urethral deformity in a kitten
Authors: Henry Perrine , Schiavo Luca , Owen Laura , McCallum Katie E 
Published: September 2021

Case summary A 5-month-old entire male domestic shorthair kitten was referred for investigation of a month-long history of urinary incontinence. Clinical examination, baseline blood work and imaging (plain radiography and ultrasonography) were unremarkable. Urinalysis documented a urinary tract infection and a retrograde urethrocystogram revealed an outpouching of the pelvic urethra. Surgical exploration revealed the absence of the dorsal portion of the urethral wall in this section of pelvic urethra, replaced by an epithelial lined expanded ‘pouch’. The ventral aspect of the urethra appeared grossly normal. A modified perineal urethrostomy was performed to create an anastomosis of the urethral pouch to the skin of the perineum alongside conventional castration. The kitten made a full recovery and the incontinence resolved within 48 h. A congenital urethral diverticulum and secondary urinary tract infection were deemed the most likely aetiology in this case. Relevance and novel information Urethral diverticuli are a rare condition in veterinary medicine. To our knowledge, it has only been reported in two dogs and presumptively in one cat, all of which made a complete recovery after surgical intervention. The present case reports an unusual urethral deformity as a potential differential diagnosis for lower urinary tract signs in a young cat.
Satisfaction of General Versus Specialized Continuity Clinic in Hematology Oncology Fellowship Training: A Survey
Authors: Ilyas Sama , Murphy Martina , Duff Jennifer , Close Julia 
Published: September 2021

Background: At the University of Florida (UF), hematology-oncology (HO) fellows participate in 2 general types of continuity clinic as part of their fellowship training. One clinic, at the Veterans Hospital (VA), allows fellows to care for patients with a variety of hematology oncology diagnoses in a general clinic setting. The other clinic, located at the university site, is disease or system specific (such as breast or GI clinic). Considerable research supports the value of continuity clinic in residency and fellowship training, but the differences in having a general versus specialized clinic for HO fellows have not been explored. The purpose of this study was to investigate the perceived differences of general versus specialized continuity clinics by recent HO graduates from UF. Specifically, we were interested in learning which features of a continuity clinic they felt were most impactful for their current clinical practice. Methods: An anonymous survey was sent to the last 6 graduating classes of HO fellows at UF, between years of 2013 and 2018. The survey contained short demographic questions, followed by 5 open ended questions pertaining to the differing continuity clinic experiences. Graduates were asked about their opinions of both the general and specialized clinics during their training at UF. Survey responses were reviewed and coded for common themes by the authors. Results: Of 28 graduating fellows surveyed, 13 responded to the survey (response rate 46%). In thematic review of survey responses, the most common themes that emerged concerned autonomy, level of supervision, and the diversity of the patient population. A majority of respondents felt they had more autonomy and personal responsibility at the VA general clinic, but less direct supervision than at the specialized clinics. They also believed they got a broader exposure to different disease types at the VA general clinic. Surveyed participants also commented on the quality of educational seminars and activities, preceptor expertise and teaching, and ability to observe cutting edge practice and clinical trials. Conclusions: Graduated oncology fellows from UF believe that there is a balance that exists between having autonomy and ownership of their patients versus having adequate supervision. Many believe that having “controlled autonomy” and “as much independence as is safe for patients” is key to a meaningful continuity clinic experience during oncology fellowship training.
Risk Factors for 30‐Day Mortality After Head and Neck Microsurgical Reconstruction for Cancer: NSQIP Analysis
Authors: Ali Barkat , Choi EunHo Eunice , Barlas Venus , Petersen Timothy R. , Menon Nathan G. , Morrell Nathan T. 
Published: September 2021

ObjectiveTo identify the incidence and risk factors for 30‐day postoperative mortality after microsurgical head and neck reconstruction following oncological resection.Study DesignRetrospective case‐control study.SettingAmerican College of Surgeons National Surgical Quality Improvement Program (NSQIP) database.MethodsMicrosurgical head and neck reconstructive cases were identified from 2005 to 2018 using Current Procedural Terminology codes and oncologic procedures using the International Classification of Disease 9 and 10 codes. The outcome of interest was 30‐day mortality.ResultsThe 30‐day postoperative mortality rate was 1.2%. Univariate logistic regression analysis identified the following associations: age >80 years, hypertension, poor functional status, preoperative wound infection, renal insufficiency, malnutrition, anemia, and prolonged operating time. Multivariable logistic regression models were used to stratify further by the degree of malnutrition and anemia. Hematocrit <30% was found to be an independent risk factor for 30‐day postoperative mortality (odds ratio [OR] = 9.59, confidence interval [CI] 2.32‐39.65, P <. 1) with albumin <3.5 g/dL. This association was even stronger with albumin <2.5 g/dL (OR = 11.64, CI 3.06‐44.25, P <. 01). One‐third of patients (36.6%) had preoperative anemia, of which less than 1% required preoperative transfusion, although one‐quarter (24.6%) required intraoperative or 72 hours postoperative transfusion.ConclusionsPreoperative anemia is a risk factor for 30‐day postoperative mortality. This association seems to get stronger with worsening anemia. Identification and optimization of such patients preoperatively may mitigate the incidence of 30‐day postoperative mortality.
Clinical and Radiological Profile of Patients Presenting With Isolated Acute Cerebellar Infarct: A Single Tertiary Center 3 Years Retrospective Study From Central Stroke Unit, Muscat, Oman
Authors: Hashmi Amal M. Al , Aaron Sanjith , Sinani Ahmed Al , Pancharatnam Divyan 
Published: September 2021

Introduction: Cerebellar infarct can present with a broad spectrum of clinical and radiographic features. Recognizing this spectrum is extremely important for prompt diagnosis and to avoid morbidity and mortality. Objective: To identify the clinical and radiological profile of patients presenting with isolated acute cerebellar infarct. Methods: Retrospective study carried out at the central stroke unit of Oman over 27 months. Only patients with isolated acute cerebellar infarct confirmed by either magnetic resonance imaging or computerized tomography (CT) were included in this study. A total of 76 cases were identified. Results: Isolated cerebellar infarct constituted 4% of all acute ischemic strokes treated during the study period. Gait imbalance and difficulty in articulating were seen in 30/48 (63%) and 12/48 patients (25%), respectively. Ataxia and nystagmus were the main signs seen 30/48 (63%) and 10/48 (21%), respectively. Large artery atherosclerosis comprised 15/48 (31%), of the underlying etiology. Normal and complete posterior circulation was seen only in 6/36 (17%). Unilateral or bilateral hypoplasia or absence of posterior communicating artery (PCOM) were the commonest variants seen in our patients. The cerebellar arterial territory most commonly involved in this series was posterior inferior cerebellar artery (58%). Infarct extension was seen in 10/48 patients (21%), with 4/10 (40%) having bilateral absent PCOM followed by 2/10 (20%) normal posterior circulation. Conclusions: Acute gait imbalance and difficulty in articulating can be the only presenting symptoms in isolated cerebellar infarct. Plain CT in the acute phase can miss such infarcts in up to 46% cases. The majority of cases had an incomplete anatomy of the posterior circulation.
In situ synthesis of zeolites by geopolymerization with NaOH/KOH mixed solution and their potential application for Cd(II) immobilization in paddy soil
Authors: Wu Di , Huang Yi , Xiao Guqing , Li Xuan , Yao Xia , Deng Zixuan , Tan Rui 
Published: September 2021

AbstractGeopolymers can be transformed into zeolites under certain synthesis conditions. However, zeolite formation is not frequently reported in KOH-activated geopolymers. This study attempted to explore zeolite synthesis through geopolymerization for a curing time of 24 h using mixed NaOH/KOH alkaline solution as an activator, and then applying the geopolymer-supported zeolites to immobilize Cd(II) in paddy soil. The K2O/M2O–H2O/SiO2 and K2O/M2O–OH–/SiO2 binary zeolite crystallization phase diagrams were obtained. Zeolite A, faujasite and sodalite formed at lower K2O/M2O molar ratios (0–0.2), ferrierite formation was favoured at a K2O/M2O molar ratio of 0.2–0.4 and zeolite K-I and zeolite F-K (both K-zeolites) were observed at a K2O/M2O molar ratio of 0.6. The geopolymer-supported zeolites had micropores and mesopores and specific surface area values of 44.2–74.8 m2 g–1. The material displayed a considerable Cd(II) immobilization efficiency (55.6–58.7% at 4–6 wt.% addition of zeolite).
Efficacy of galcanezumab in patients with migraine and history of failure to 3–4 preventive medication categories: subgroup analysis from CONQUER study
Authors: Okonkwo Rose , Tockhorn-Heidenreich Antje , Stroud Chad , Paget Marie-Ange , Matharu Manjit S. , Tassorelli Cristina 
Published: September 2021

Abstract
Background
Chronic migraine (CM) and episodic migraine (EM) are associated with substantial headache-related disability, poor quality of life and global societal burden. In this subgroup analysis from the CONQUER study, we report efficacy outcomes from a pre-specified analysis of galcanezumab versus placebo in patients with CM or EM and 3–4 prior preventive medication category failures due to inadequate efficacy (after at least 2 months at maximum tolerated dose), or safety or tolerability reasons. The patient population is of particular interest due to evidence of decreased quality of life and increased economic burden among patients with migraine that is inadequately managed and is of interest to decision-makers globally.

Methods
Key outcomes included overall mean change from baseline in monthly migraine headache days and proportions of patients achieving ≥30% (CM), ≥50%, and ≥ 75% reduction (response rates) in monthly migraine headache days across Months 1–3. Patient functioning and disability were evaluated at Month 3.

Results
Of the 462 randomized patients, 186 (40.3%) had a history of 3–4 preventive category failures. Galcanezumab versus placebo resulted in significantly (P ≤ .001) larger overall mean reduction in monthly migraine headache days (total: − 5.49 versus − 1.03; CM: − 6.70 versus − 1.56; EM: − 3.64 versus − 0.65). Similarly, the ≥50% response rate was significantly (P ≤ .001) higher with galcanezumab versus placebo (total: 41.0 versus 12.7; CM: 41.5 versus 8.4; EM: 41.1 versus 16.5). In the CM group, the ≥30% response rate was significantly higher in the galcanezumab group than the placebo group (CM, 57.5 versus 19.8, P ≤ .0001) as was the ≥75% response rate (13.3 versus 2.6, P ≤ .05). Galcanezumab also resulted in significant (P < .0001) improvements in patient functioning and reductions in disability.

Conclusions
Galcanezumab was effective in a difficult-to-treat population of patients with CM or EM who had failed 3–4 prior preventive medication categories.

Trial registration
CONQUER. Clinicaltrials.gov identifier: NCT03559257.