bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESAIN PERENCANAAN PEMBELAJARAN BERBASIS DIFFERENTIATED INSTRUCTION (DI) PADA MATA KULIAH ALJABAR
Authors: Defitriani Eni , Faisal Hidayat Akhmad 
Published: October 2021

Aljabar adalah salah satu mata kuliah dasar yang menjadi prasyarat mata kuliah lainnya. Keberhasilan calon guru matematika dalam mata kuliah Aljabar, akan berdampak pada keberhasilannya dalam memahami konsep yang lebih kompleks serta akan memudahkan mereka untuk mentransfer pengetahuannya kepada peserta didik. Tujuan penelitian ini adalah untuk mendesain perencanaan pembelajaran berbasis Differentiated Instruction (DI) pada mata kuliah Aljabar. Metode penelitian adalah penelitian pengembangan dengan metode ADDIE (Analysis, Design, Development, Implementation, and Evaluation) yang dikembangkan sampai tahap Analysis dan Design. Pada tahap analisis, dilakukan analisis kurikulum, analisis materi, dan analisis karakteristik siswa. Pada tahap desain, dilakukan desain perencanaan pembelajaran berbasis DI dengan berfokus pada differensiasi isi, proses, dan produk.
PENGGUNAAN MEDIA YOUTUBE UNTUK MENINGKATKAN PEMAHAMAN MAHASISWA PGSD PADA MATERI SIMETRI DI STKIP MUHAMMADIYAH OKU TIMUR
Authors: Zabeta Mewa 
Published: October 2021

Penelitian ini bertujuan untuk meningkatkan pemahaman mahasiswa PGSD di STKIP Muhammadiyah OKU Timur pada materi simetri melalui penggunakan media youtube. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Subyek penelitian ini adalah mahasiswa PGSD di STKIP Muhammadiya OKU Timur angkatan pertama pada tahun 2019-2020. Metode pengumpulan data dilakukan melalui metode observasi, tes dan dokumentasi. Teknik analisis data menggunakan metode yang meliputi pengumpulan data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan adanya peningkatan pemahaman mahasiswa mengenai konsep dasat simetri pada mata kuliah geometri dan pengukuran pada saat semester genap. hal ini dapat dilihat melalui nilai tes yang dihasilkan pada tes awal pembelajaran nilai tertinggi 70 dan nilai terendah 35 dengan rata-rata nilai 48 dan rentan nilai 35, pada siklus I nilai kuis 1, nilai tertinggi 72 dan nilai terendah 40 dengan rata-rata nilai 55 dan rentan nilai 32 sedangkan siklus II, nilai tertinggi 95 dan nilai terendah 65 dengan rata-rata nilai 76 dan rentan nilai 30. Kesimpulan penelitian ini adalah bahwa penggunakan media youtube dapat meningkatkan pemahaman mahasiswa PGSD di STKIP Muhammadiyah OKU Timur pada materi simetri.
Perbedaan Frekuensi Pemberian Enteral Feeding terhadap Toleransi Feeding dan Kadar Glukosa Darah
Authors: Oktavianti Dewi Siti , Yulia Yulia , Maria Riri 
Published: October 2021

Medical nutrition therapy is one of the interventions to provide sufficiently nutrition and to optimize glycemic controls in meeting the body metabolic needs. An Enteral Feeding is an alternative feeding method when there are obstacles to fulfill patients nutrition orally. This study aims to determine feeding tolerances and blood glucose controls in Type2 Diabetes Mellitus patients with different Enteral Feeding frequencies-three and six times preserving. This research is a quasi-experimental design study involving 26 patients admitted in a hospital. The results of the study on respondents with enteral feeding of a frequency 3x/24 hours found that 2respondents (15.4%) were tolerant with enteral feeding given and as many as 3respondents (23.1%) had normal blood glucose, while the results of the study for respondents with enteral feeding of a frequency 6x / 24 hours, 12 respondents (92.3%) were tolerant with enteral feeding given and as many as 12 respondents (92.3%) had normal blood glucose.
The results showed that there was a statistically difference between the three times and six times Enteral Feeding with feeding tolerance (p = 0.005). There was a difference between the frequency of enteral feeding six times and three times in the blood glucose level (p = 0.005). Results of this study will assist in controlling blood glucose by regulating the timing of feeding in patients with type 2 diabetes mellitus.
Evaluación de las características de tipo y producción en ganado Holstein del Criadero Pacaguan
Authors: Guayasamin de la Cruz Jessica Silvana , Almeida-López Fabian Augusto , Díaz-Berrones Hermenegildo 
Published: October 2021

La “evaluación de las características de tipo y producción en ganado Holstein se realizó en el “Criadero Pacaguan”, ubicado en el Cantón Penípe, Parroquia Quimiag, sector la Candelaria, las unidades experimentales estuvieron constituidas por 60 animales, en la etapa de producción, para la comprobación de las hipótesis y la tabulación de los datos se realizó el cálculo mediante estadística descriptiva y coeficiente de correlación. Por lo que los resultados indicaron que en el criadero “Pacaguan¨”, al realizar la evaluación de las características en las vacas en producción, se observó que para las variables ubicación de pezones anteriores, locomoción, posición coxo femoral, longitud de pezones, ángulo de pezuñas, patas posteriores vista lateral, profundidad de la ubre e inclinación se alcanzaron valores altos con 4.48, 7.07, 5.28, 5.35, 5,12, 5.32,5.67, 4.67 puntos respectivamente, en cuanto a la valoración de los datos más bajos se encontraron en inserción anterior de la ubre, altura de la ubre posterior y anchura de la ubre trasera con 5.90, 5.72, 4,47 puntos en el orden antes mencionado. En la correlación tipo – producción las características que más influyen en la misma son la inclinación de la ubre con una significancia bilateral de 0,932, que identifica una relación positiva alta mientras tanto que para ancho de la grupa el valor de significancia fue 0,224 es decir una relación positiva baja. Concluyendo que se debe utilizar toros con altos índices de componentes de ubre al ser uno de los criterios negativos en el promedio del hato, las presencias de estas características con valores altos son fundamentales en la producción del hato. Se hace fundamental mantener en el hato vacas funcionales que paran una vez al año, sanas y para esto es esencial el seleccionar toros para la inseminación artificial que combinen con las características de producción, longevidad y tipo.
Appropriate Age for Height Control Treatment in Patients With Marfan Syndrome
Authors: Kim Sung Eun , Lee Dong-Yun , Kim Min-Sun , Cho Sung Yoon , Jin Dong-Kyu , Choi DooSeok 
Published: October 2021

ObjectiveThis study aimed to determine the most appropriate age for height control treatment in patients with Marfan syndrome (MFS).Materials and MethodsThis retrospective study included patients with MFS who underwent height control treatment with estradiol valerate. The estrogen dose was increased according to the height change. The cut-off age for the maximum difference between the expected height and actual final height was evaluated.ResultsSeventeen patients were included in this study. The difference between the height predicted by the growth curve and the final height (gcHtD) and that predicted by the bone age and the final height (baHtD) was the largest in the 10.5 years age group (p=0.0045 and p=0.0237, respectively). The gcHtD was 10.6 (10.2, 13.5) cm for patients aged ≤10.5 years, whereas it was 0.6 (−3.65, 5.85) cm for patients aged &gt;10.5 years. The baHtD was 10.1 (7.31, 11.42) cm for patients aged ≤10.5 years, while it was 3.83 (0.84, 6.4) cm for patients aged &gt;10.5 years. When height change was observed for a minimum of 6 months after completion of estrogen treatment, the average growth was 0.6 (0.2, 2.1) cm.ConclusionInitiating height control treatment before the age of 10.5 years is effective in female patients with MFS.
Encounters in Three Dimensions: How Nuclear Topology Shapes Genome Integrity
Authors: Sebastian Robin , Aladjem Mirit I. , Oberdoerffer Philipp 
Published: October 2021

Almost 25 years ago, the phosphorylation of a chromatin component, histone H2AX, was discovered as an integral part of the DNA damage response in eukaryotes. Much has been learned since then about the control of DNA repair in the context of chromatin. Recent technical and computational advances in imaging, biophysics and deep sequencing have led to unprecedented insight into nuclear organization, highlighting the impact of three-dimensional (3D) chromatin structure and nuclear topology on DNA repair. In this review, we will describe how DNA repair processes have adjusted to and in many cases adopted these organizational features to ensure accurate lesion repair. We focus on new findings that highlight the importance of chromatin context, topologically associated domains, phase separation and DNA break mobility for the establishment of repair-conducive nuclear environments. Finally, we address the consequences of aberrant 3D genome maintenance for genome instability and disease.
Perspectives and Management of Atypical Asthma in Chinese Specialists and Primary Care Practitioners—A Nationwide Questionnaire Survey
Authors: Huang Huaqiong , Hua Wen , Chen Ruchong , Hu Yue , Ying Songmin , Chi Chunhua , Zhang Min , Huang Kewu , Liu Huiguo , Shen Huahao , Lai Kefang 
Published: October 2021

Background and objective: To evaluate the awareness/knowledge and clinical practice for the treatment of atypical asthma among respiratory specialists and primary care practitioners (PCPs) in China.Methods: A total number of 1,997 physicians participated in the survey via WeChat. The questionnaire included six main items: physician demographic characteristics, awareness, diagnosis, medical prescription, assessment/education, and proposal.Results: Cough variant asthma (CVA) was recognized by 97.51% of physicians (1,166 respiratory specialists and 799 PCPs), followed by chest tightness variant asthma (CTVA, 83.72%) and occult asthma (73.54%). Specialists were more likely to follow diagnostic recommendations than PCPs (P &lt; 0.01); however, 34.15% of physicians reported the utility of bronchodilation tests, airway provocation tests, and peak expiratory flow monitoring. A total of 91.70% and 92.01% of physicians prescribed inhaled corticosteroids (ICS) or ICS plus long-acting beta-agonists (LABA) for CVA and CTVA, respectively. Physicians prescribed an ICS or ICS/LABA for 4 (2–8) or 8 (4–12) weeks for CVA and 4 (2–8) or 5 (4–12) weeks for CTVA, and the prescription durations were significantly shorter for PCPs than for specialists (P &lt; 0.01). Further, 52.42% and 35.78% reported good control of CVA and CTVA, respectively, with significantly lower control rates for PCPs than for specialists (P &lt; 0.01). Additionally, specialists exhibited better assessment and educational habits than PCPs.Conclusion: While atypical asthma was identified by most specialists and PCPs, there remains a gap between management in real clinical practice and guideline recommendations, especially for PCPs. Further training of PCPs and clinical studies of atypical asthma are required to improve practice.
Does Use of Acupuncture Reduce the Risk of Type 2 Diabetes Mellitus in Patients With Rheumatoid Arthritis? Evidence From a Universal Coverage Health Care System
Authors: Chen Wei-Jen , Livneh Hanoch , Chen Chi-Hsien , Huang Hui-Ju , Liu Wen-Jiun , Lu Ming-Chi , Tsai Tzung-Yi 
Published: October 2021

Objectives: Although acupuncture is often advocated for patients with rheumatoid arthritis (RA), its efficacy for type 2 diabetes mellitus (T2DM), a common metabolic disease among RA cohorts, has not yet been established. This retrospective cohort study aimed to determine the association between acupuncture use and the development of T2DM among them.Methods: Data were collected from 1999 through 2008 for individuals aged 20–70 years in the nationwide insurance database of Taiwan. From them, we extracted 4,941 subjects within newly diagnosed RA and being T2DM free at baseline. A total of 2,237 patients had ever received acupuncture, and 2,704 patients without receiving acupuncture were designated as a control group. All of them were followed to the end of 2013 to identify T2DM incidence. The Cox proportional hazards regression model was utilized to obtain the adjusted hazard ratio (HR) for acupuncture use.Results: Compared with the RA subjects without use of acupuncture, the incidence of T2DM was lower for those who received acupuncture, with the incidence rates of 24.50 and 18.00 per 1,000 person-years (PYs), respectively. After adjusting for potential confounders, use of acupuncture was significantly related to the lower T2DM risk, with the adjusted HR of 0.73 [95% confidence interval (CI) 0.65–0.86]. Those who used acupuncture for more than five sessions had the greatest benefit in lowering the susceptibility to T2DM.Conclusion: Adding acupuncture into conventional treatment for RA was found to be related to lower risk of T2DM among RA patients. Further clinical and mechanistic studies are warranted.
A Nomogram to Predict Disease-Free Survival Following Neoadjuvant Chemotherapy for Triple Negative Breast Cancer
Authors: Zhu Meizhen , Liang Chenlu , Zhang Fanrong , Zhu Liang , Chen Daobao 
Published: October 2021

BackgroundNeoadjuvant chemotherapy (NACT) is considered a standard treatment strategy for locally advanced triple negative breast cancer (TNBC). TNBC patients who achieve a pathologic complete response (pCR) are predicted to have a better prognosis while unfavorable chemo-sensitivity is still associated with a higher risk of disease relapse. The objective of this study was to construct a nomogram to predict disease-free survival (DFS) for TNBC patients following NACT.MethodsA total of 165 TNBC patients who underwent standard NACT and surgery were retrospectively reviewed, and data on their clinicopathological factors before and after NACT were collected. Independent prognostic factors for DFS were identified by Cox regression based on lower Akaike information criteria (AIC) and Bayesian information criterion (BIC). A nomogram to predict the 2-year and 5-year DFS following NACT for TNBC was constructed based on training cohort (n = 132) and validated by a validation cohort (n = 33).ResultsEither limited or full pCR (breast-only pCR, node-only pCR, or both-pCR) indicated significantly improved DFS and overall survival (OS) (p &lt; 0.001). Lager residual tumor size (hazard ratio [HR] 1.175, p = 0.011) and the presence of lymphatic vessel invasion (LVI) (HR 3.168, p = 0.001) were identified as independent predictors of disease relapse in the training cohort. Five variables, including age, primary tumor size, histological grade, residual tumor size, and LVI were used to establish the nomogram. The C-index of the nomogram was 0.815, and calibration curves showed an acceptable consistency between the actual and nomogram-predicted 2-year and 5-year DFS. The proposed nomogram demonstrated superior predictive performance compared with Residual Cancer Burden (RCB) classification and the 8th American Joint Committee on Cancer Post Neoadjuvant Therapy Classification (AJCC ypTNM) staging system (area under the curve [AUC] for 2-year DFS: 0.870 vs. 0.758 vs. 0.711, respectively; AUC for 5-year DFS: 0.794 vs. 0.731 vs. 0.702, respectively) in the validation cohort.ConclusionsThe nomogram proposed in our study enabled to quantify the risk of disease relapse and demonstrated superior predictive performance than a survival predict instrument. It was an easy-to-use tool for clinicians to guide individualized surveillance of TNBC patients following standard NACT.
Preoperative Serum Prealbumin Level and Adverse Prognosis in Patients With Hepatocellular Carcinoma After Hepatectomy: A Meta-Analysis
Authors: Fan Yu , Sun Yimeng , Man Changfeng , Lang Yakun 
Published: October 2021

BackgroundPrealbumin is a sensitive indicator of liver function and nutritional status.ObjectivesThis meta-analysis aimed to examine the association of the serum prealbumin level with the prognosis of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy.MethodsWe comprehensively searched the PubMed, Embase, Wanfang, China Academic Journals (CNKI), and SinoMed databases up to September 1, 2021. Eligible studies should report the association of the serum prealbumin level with prognosis and provide the multivariable-adjusted risk estimates of the outcomes of interest in HCC patients undergoing hepatectomy.ResultsA total of 11 studies with 7,442 HCC patients were identified and analyzed. Meta-analysis of a fixed effects model showed that a low serum prealbumin level was associated with poor overall survival [hazard ratio (HR) = 1.54, 95% confidence interval (CI) = 1.42–1.68], recurrence-free survival (HR = 1.34, 95% CI = 1.17–1.52), and a higher risk of postoperative hepatic insufficiency (HR = 2.21; 95% CI = 1.36–3.60) in HCC patients. Sensitivity and subgroup analyses confirmed the robustness of low serum prealbumin in predicting poor overall survival.ConclusionsThis meta-analysis indicated that a low preoperative serum prealbumin level was significantly associated with adverse prognosis in HCC patients undergoing hepatectomy.
Predicting Treatment Outcomes in Guided Internet-Delivered Therapy for Anxiety Disorders—The Role of Treatment Self-Efficacy
Authors: Schønning Adrian , Nordgreen Tine 
Published: October 2021

Aim: Guided Internet-delivered therapy has shown to be an effective treatment format for anxiety disorders. However, not all patients experience improvement, and although predictors of treatment outcome have been identified, few are consistent over time and across studies. The current study aimed to examine whether treatment self-efficacy (self-efficacy regarding the mastery of obstacles during treatment) in guided Internet-delivered therapy for anxiety disorders in adults could be a predictor of lower dropout rates and greater symptom reduction.Method: The analyzed data comes from an open effectiveness study including 575 patients receiving guided Internet-delivered therapy for panic disorder or social anxiety disorder. Treatment self-efficacy was measured at pre-treatment. Symptom reduction was measured at 10 measurement points, including a 6-month follow-up. A mixed linear model was applied in the analysis.Results: The results showed that high treatment self-efficacy was a predictor of both lower dropout rates and greater symptom reduction. Significant interaction effects between time and treatment self-efficacy were found for several of the nine modules that constitutes the treatment program, suggesting that treatment self-efficacy could be a moderator of symptom reduction. Three of nine modules in the panic disorder treatment and six of nine in the social anxiety disorder treatment showed significant interaction effects.Conclusion: The results suggest that measuring treatment self-efficacy may be a valuable tool to identify patients at risk of dropping out, and that treatment self-efficacy could be a predictor and moderator of symptom reduction in guided Internet-delivered therapy. The implications of the results are discussed.
The Unevenness of Construction Market Development and Regional Infrastructure Development in Russia
Authors: Kotlyarova S. N. 
Published: October 2021

Aim. The presented study aims to address the issues of the unevenness of construction market development and regional infrastructure development in the Russian Federation.Tasks. The authors analyze the scale of the construction markets in Russian regions and compare it with the level of infrastructure development.Methods. This study uses statistical methods of information processing, including the index method, ranking, and expert assessment. Input data for the analysis include official statistical reports of the Federal State Statistics Service (major socio-economic indicators and indicators of construction activity development in the constituent entities of the Russian Federation), analytical reviews of InfraOne Research — Russian infrastructure: development index 2020, and data from the SPARK service.Results. The study examines the specific features of regional construction market development and divides regions into five groups based on the scale of construction markets. The authors assess the relationship between the volume of construction works and the scale of the contractor market with the values of the infrastructure development index and the volume of housing commissioning. It is concluded that there is a mutual influence between the scale of the construction market and the level of infrastructure development. The results of the study can be used in the development (updating) of strategies for the development of the construction complex and infrastructure, as well as in the implementation of government policy in this area.Conclusions. Based on the analysis of the volume of construction works, Russian regions are divided into five groups depending on the scale of the construction market. The scale is assessed based on the extent of the region’s contribution to the total volume of construction works performed in the Russian Federation. Assessment of the relationship between the volume of construction works and the scale of the contractor market with the values of the infrastructure development index indicates that regions with a large volume of construction works have a higher infrastructure development index. The volume of construction works and the number of construction companies do not always have an effect the infrastructure development index.
La crisis del transporte ferroviario de mercancías en Galicia: Una potencialidad no aprovechada en la cadena intermondal del transporte. 1970-2010
Authors: Díaz Fernández José Antonio 
Published: October 2021

El sistema de transportes y comunicaciones en Galicia presenta unos marcados síntomas de bajo nivel de integración de la cadena multimodal del transporte. La articulación del sistema de transportes está funcionando en unos estándares de participación muy lateralizados a favor de la carretera. Por su parte, la concurrencia en el mercado del transporte por ferrocarril arroja unos valores de acentuada marginalidad en su cuota de mercado. La evolución del transporte de mercancias por ferrocarril en Galicia nos aclara dos factores. Por un lado, la demanda de desplazamiento de mercancías por el tren ha sido siempre regresiva en sus principales segmentos del mercado. Por su parte, los valores de la carretera han sido siempre expansivos. En segundo lugar, las elevadas potencialidades que presenta el ferrocarril se encuentran muy sub-explotada. La dotación de infraestructuras del transporte no ofrece una óptima conexión puerto-ferrocarril para impulsar el flujo de mercancías con matriz de viaje O-D en Galicia.
La mala articulación modal de los dos sistemas de transporte se traduce en:
a) Una caída en los registros del volumen del tonelaje movilizado por el tren
b) La pérdida de nichos de mercado a favor de la carretera
c) La pérdida de relaciones territoriales en la matriz de viaje O-D
d) La baja especialización operativa del tren gallego al corurrir en el mercado del transporte.