bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of, Barriers to, and Needs for an Artificial Intelligence–Powered Medication Information Voice Chatbot for Older Adults: Interview Study With Geriatrics Experts
Authors: Gudala Meghana , Ross Mary Ellen Trail , Mogalla Sunitha , Lyons Mandi , Ramaswamy Padmavathy , Roberts Kirk 
Published: December 2021

Background
One of the most complicated medical needs of older adults is managing their complex medication regimens. However, the use of technology to aid older adults in this endeavor is impeded by the fact that their technological capabilities are lower than those of much of the rest of the population. What is needed to help manage medications is a technology that seamlessly integrates within their comfort levels, such as artificial intelligence agents.

Objective
This study aimed to assess the benefits, barriers, and information needs that can be provided by an artificial intelligence–powered medication information voice chatbot for older adults.

Methods
A total of 8 semistructured interviews were conducted with geriatrics experts. All interviews were audio-recorded and transcribed. Each interview was coded by 2 investigators (2 among ML, PR, METR, and KR) using a semiopen coding method for qualitative analysis, and reconciliation was performed by a third investigator. All codes were organized into the benefit/nonbenefit, barrier/nonbarrier, and need categories. Iterative recoding and member checking were performed until convergence was reached for all interviews.

Results
The greatest benefits of a medication information voice-based chatbot would be helping to overcome the vision and dexterity hurdles experienced by most older adults, as it uses voice-based technology. It also helps to increase older adults’ medication knowledge and adherence and supports their overall health. The main barriers were technology familiarity and cost, especially in lower socioeconomic older adults, as well as security and privacy concerns. It was noted however that technology familiarity was not an insurmountable barrier for older adults aged 65 to 75 years, who mostly owned smartphones, whereas older adults aged >75 years may have never been major users of technology in the first place. The most important needs were to be usable, to help patients with reminders, and to provide information on medication side effects and use instructions.

Conclusions
Our needs analysis results derived from expert interviews clarify that a voice-based chatbot could be beneficial in improving adherence and overall health if it is built to serve the many medication information needs of older adults, such as reminders and instructions. However, the chatbot must be usable and affordable for its widespread use.
Implementation Frameworks for Artificial Intelligence Translation Into Health Care Practice: Scoping Review
Authors: Gama Fábio , Tyskbo Daniel , Nygren Jens , Barlow James , Reed Julie , Svedberg Petra 
Published: December 2021

Background
Significant efforts have been made to develop artificial intelligence (AI) solutions for health care improvement. Despite the enthusiasm, health care professionals still struggle to implement AI in their daily practice.

Objective
This paper aims to identify the implementation frameworks used to understand the application of AI in health care practice.

Methods
A scoping review was conducted using the Cochrane, Evidence Based Medicine Reviews, Embase, MEDLINE, and PsycINFO databases to identify publications that reported frameworks, models, and theories concerning AI implementation in health care. This review focused on studies published in English and investigating AI implementation in health care since 2000. A total of 2541 unique publications were retrieved from the databases and screened on titles and abstracts by 2 independent reviewers. Selected articles were thematically analyzed against the Nilsen taxonomy of implementation frameworks, and the Greenhalgh framework for the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) of health care technologies.

Results
In total, 7 articles met all eligibility criteria for inclusion in the review, and 2 articles included formal frameworks that directly addressed AI implementation, whereas the other articles provided limited descriptions of elements influencing implementation. Collectively, the 7 articles identified elements that aligned with all the NASSS domains, but no single article comprehensively considered the factors known to influence technology implementation. New domains were identified, including dependency on data input and existing processes, shared decision-making, the role of human oversight, and ethics of population impact and inequality, suggesting that existing frameworks do not fully consider the unique needs of AI implementation.

Conclusions
This literature review demonstrates that understanding how to implement AI in health care practice is still in its early stages of development. Our findings suggest that further research is needed to provide the knowledge necessary to develop implementation frameworks to guide the future implementation of AI in clinical practice and highlight the opportunity to draw on existing knowledge from the field of implementation science.
Alcohol dehydrogenase 1C (ADH1C) polymorphism is significantly associated with kidney function status in Nusa Tenggara Timur ethnicity: A cross-sectional study
Authors: Noormaningrum Budiatri Retno , Nurhantari Yudha , Suhartini Suhartini , Ratnaningsih Tri , Dedy Maria Agnes Etty 
Published: December 2021

Excessive alcohol consumption is harmful to many human organs, but the association with kidney function is still controversial. The disagreement in findings might be caused by ADH1C polymorphism's influence on alcohol metabolism rate. This study aims to determine the correlation between ADH1C polymorphism and kidney function status in Nusa Tenggara Timur (NTT) ethnicity, a population with highly prevalent alcohol consumption in Indonesia. We conducted a cross-sectional study of 76 subjects, who are natives of NTT, Indonesia. The genotyping of extracted DNA for ADH1C was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using restriction endonuclease SspI. Kidney function status was defined by serum urea level and estimated glomerular filtration rate (eGFR) that had been categorized according to percentiles. The correlation with the ADH1C allele was analyzed using chi-square tests. The genotype of ADH1C in NTT ethnicity was ADH1C*1/*2 (51.3%), ADH1C*2/*2 (47.4%), and ADH1C*1/*1 (1.3%). The results showed that the population had the ADH1C*2 (73.03%) and the ADH1C*1 (26.97%) allele. There was a significant association between ADH1C polymorphism and eGFR among NTT ethnicity (p=0.005) when eGFR was analyzed at the 25th percentile (74.75 mL/minute/1.73m2). However, we found no associations when eGFR was analyzed at 50th (p=0.571) and 75th (p=0.335) percentiles. The odds ratio shows that having the ADH1C*1/*2 genotype escalates the probability of declining eGFR 6.620 times compared to ADH1C*2/*2 (95% CI: 1.539-28.478), after adjusted for smoking behavior. We found no association between ADH1C polymorphism and serum urea level (p=0.123, 0.421, and 0.335). The majority of NTT ethnicity have the ADH1C*1/*2 genotype. Populations with ADH1C*1/*2 have higher odds ratio for eGFR below 74.75 mL/minute/1.73m2 than those with ADH1C*2/*2 genotype. There was no association between ADH1C polymorphism and serum urea levels.
Community based intervention: Local village preparedness in prevention and control of COVID-19
Authors: Jauhar Muhamad , Rasdiyanah Rasdiyanah , Kusumawardani Lita Heni , Rachmawati Utami , Ayu Putu Desy Rohana I Gusti 
Published: December 2021

The COVID-19 pandemic has become a global concern since it has severely affected various aspects of life such as health, economy, society, culture, and religion. Community empowerment in breaking the chain of region-based COVID-19 spread is an effective approach that can be taken. This intervention is an important alternative measure to slow the morbidity and mortality of COVID-19 that continue to occur in Indonesia. This article aimed to describe the implementation of a community-based COVID-19 prevention program that was conducted among 280 families in six sub-districts in Brebes Regency from May to June 2020. The assessment used a questionnaire of COVID-19 transmission risk, with a total of 29 indicators developed based on references from the Indonesian Ministry of Health. The preliminary assessment of our program found several aspects that were related to the risk of COVID-19 transmission in the village and observed that there was insufficient public knowledge about COVID-19 including poor practice of health protocols and the negative stigma of society towards patients with COVID-19. The community-based program involved several activities, which namely consisted of program introduction, coordination with stakeholders, community assessments, group discussions, village community deliberations, health education about COVID-19 and 6 step hand washing, distribution of cloth masks, socialization of mask usage and care, socialization of pregnancy checks during the pandemic, provision of hand washing facilities in front of the house, activities evaluation, follow-up plans, and closings. Furthermore, the aforementioned activities also used videos, posters, leaflets, WhatsApp, as well as Zoom Cloud Meetings as the media. The evaluation phase of the program showed a better understanding related to COVID-19 and health protocol practice in each region. Community empowerment and collaboration with health care facilities can be pursued as a frontline solution to tackle the transmission of COVID-19. Good support and active community participation can contribute to improve the public health status.
Znaczenie diagnozy prognostycznej w resocjalizacja nieletnich sprawców przestępstw seksualnych
Authors: Pastwa-Wojciechowska Beata , Grzegorzewska Iwona 
Published: December 2021

Artykuł ma charakter przeglądowy. Zaprezentowane i omówione zostały zagadnienia związane z diagnozą prognostyczną w resocjalizacji nieletnich sprawców przestępstw. Skoncentrowano się na takich zagadnieniach, jak: istota diagnozy prognostycznej, charakterystyka nieletnich sprawców przemocy seksualnej, uwarunkowania powrotu do przestępczości nieletnich sprawców, specyfika szacowania powrotności do przestępstwa seksualnego nieletnich oraz resocjalizacja nieletnich w kontekście diagnozy prognostycznej. Przyjęcie takiej konstrukcji rozważań pozwala na analizę wczesnych predyktorów przestępczości seksualnej nieletnich a tym samym zidentyfikowanie ścieżek rozwojowych o odrębnych czynnikach przyczynowych. Podejście takie ma istotne znaczenie teoretyczne i aplikacyjne albowiem daje szansę na rozróżnienie przyczyn od konsekwencji, a tym samym zrozumienie procesów rozwojowych w kontekście normatywnym i nienormatywnym. Z kolei w aspekcie diagnostycznym i interwencyjnym pozwoliłoby na uwspólnienie tych czynności i dopasowanie ich do okresu rozwojowego.
Podejście salutogeniczne w resocjalizacji. Przegląd koncepcji
Authors: Kowalczyk Małgorzata H. 
Published: December 2021

Podejście salutogeniczne jest jednym z wiodących sposobów myślenia o resocjalizacji. Kładzie nacisk na podmiotowość osób uczestniczących w procesie resocjalizacji. Nadrzędnym celem interwencji resocjalizacyjnych jest wspomaganie zmian jakie w sposób naturalny dokonują się w życiu jednostki, koncentrując się na posiadanych przez nią potencjałach. Podejście to znajduje odzwierciedlenie w różnych koncepcjach teoretycznych popartych praktyką jak i postulowanych kierunkach interwencji resocjalizacyjnych. Jest to podejście znane także w polskiej myśli resocjalizacyjnej. Celem niniejszego teoretycznego opracowania było omówienie najważniejszych koncepcji resocjalizacji odwołujących się do tej właśnie perspektywy. Zaprezentowane zostały najbardziej znane i poparte badaniami koncepcje: twórczej resocjalizacji, wieloczynnikowego modelu gotowości sprawców oraz model dobrego życia. Wspomniane koncepcje dają możliwość niekonwencjonalnego traktowania oddziaływań resocjalizacyjnych, indywidualnego podejścia do każdej osoby wymagającej interwencji resocjalizacyjnych lub terapeutycznych i mogą być inspiracją przy projektowaniu oddziaływań wobec najtrudniejszych kategorii sprawców przestępstw.
Cultura emprendedora del programa de Administración de Empresas de la Universidad Francisco de Paula Santander, Ocaña-Colombia
Authors: Navarro-Claro Genny Torcoroma , Pacheco-Carrascal Marilce , Bayona-Trillos Ramón Armando 
Published: December 2021

El objeto del estudio fue identificar el nivel de emprendimiento de los egresados del programa de Administración de Empresas de la Universidad Francisco de Paula Santander Ocaña y evaluar la percepción del aporte de las herramientas utilizadas en la formación de competencias emprendedoras bajo la luz del modelo pedagógico constructivista social; se utilizó el método cuantitativo como cualitativo a través de la aplicación de encuestas, entrevistas y grupo focal. Se evidenció que a pesar de los esfuerzos y las prácticas académicas pocos egresados se han creado su propio negocio, en su mayoría no han generado más de dos empleos y carecen de estructura tecnológica y procesos innovadores.
Método de pruebas de integración en arquitecturas orientadas a servicios
Authors: Beltrán-Galvis Nelson , Angarita-Sanguino Carlos René , Gómez-Llanez Claudia Yamile 
Published: December 2021

El presente documento corresponde a uno de los productos del trabajo degrado de posgrado, del investigador Carlos Rene Angarita Sanguino bajo la dirección y coordinación del Magister Nelson Beltrán Galvis. En el trabajo se propone un método para las pruebas de integración en el desarrollo de software con arquitecturas orientadas a servicios. El trabajo de investigación se desarrolló en las instalaciones del grupo de Investigación y Desarrollo de Ingeniería de Sistemas de la Universidad Francisco de Paula Santander y el ejemplo de validación se realizó con la ayuda del departamento de sistemas de la Universidad Simón Bolívar sede Cúcuta, Colombia sobre el proyecto WebSimon para la consulta de información de estudiantes. Sobre el desarrollo de este proyecto se aplicaron todas las fases del método propuesto. Las nuevas tendencias en los avances tecnológicos apuntan a la integración de sistemas y gran parte de las empresas lo están haciendo o desean hacerlo; con base en esto, las empresas contratan expertos informáticos que les indiquen las estrategias a seguir para la implementación de lo último en tecnología, conduciéndolos irremediablemente a los Web Services o sistemas con Arquitecturas Orientadas a Servicios (SOA), soportados en la hipótesis de mantener interoperabilidad entre los sistemas actuales de la organización. Los SOA dentro de su metodología de desarrollo cuentan con una etapa de prueba, donde se verifica la calidad de los distintos componentes desarrollados, esta etapa es abordada con procesos de pruebas de arquitecturas tradicionales, enfocando sus esfuerzos en asegurar la calidad en el nivel de unidades y no en el nivel de integración, entendiendo por integración al proceso de consumo de las interfaces de los servicios que son expuestos. En el siguiente artículo se propone un método para el diseño y ejecución de pruebas de integración en arquitecturas orientadas a servicios, con los resultados de la aplicación del método descrito en un proyecto en la Universidad Simón Bolívar sede Cúcuta, Colombia.
Hongos asociados al material particulado, en Ocaña Norte de Santander
Authors: Granadillo-Cuello Jose Arnoldo , Armesto-Arenas Alexander , Hernández-Criado Juan Carlos , Duarte Jorge Andrés , Pedraza-Felizola Mayerly 
Published: December 2021

El objetivo de este trabajo fue caracterizar los hongos presentes en el material particulado como indicador de riesgo de enfermedades respiratorias en Ocaña norte de Santander. Para esto se muestrearon tres filtros extraídos de cada una de las estaciones de la red de monitoreo UFPSO-CORPONOR, se tomaron 5 puntos al azar dentro de cada filtro con dimensiones de 1cm2 y se inocularon en medio de cultivo agar papa dextrosa (PDA) a 20°C durante 15 días, Los resultados mostraron la presencia de 3 géneros de hongos microscópicos: Penicillium sp, Aspergillus níger, Rhizopus sp y hongos unicelulares como las levaduras, que tienen una gran incidencia en enfermedades respiratorias tales como: neumonías, micosis sistémicas, hipersensibilidad y micotoxicosis.
Methodological approaches to morbidity forecasting in military educational organizations
Authors: Zobov A. E. , Kuzin A. A. , Makiev R. G. , Zobova A. A. 
Published: December 2021

The article discusses aspects of the application of extrapolation and factor approaches to epidemiological forecasting, outlines the limitations and features of their application in relation to the prediction of morbidity.It is shown that when using an extrapolation approach, it becomes possible to predict the most likely numerical characteristics of morbidity in a certain time perspective. At the same time, the accuracy of the obtained forecast depends on the length of the time series and the type of long-term dynamics of morbidity. In turn, the trends formed by the results of forecasting artificially level the critical levels of morbidity that characterize individual periods of time and are fundamentally important for understanding the real picture.The factor approach is based on the prediction of morbidity levels using a certain set of factors. The difficulty of using the factor approach is noted due to the stochasticity of the epidemic process.Based on the results of a retrospective epidemiological analysis of the personalized morbidity of cadets of the Military Medical Academy, the heterogeneity of military contingents in susceptibility to acute respiratory infections of the upper respiratory tract is shown.From the standpoint of the academician V.D .Belyakov’s et al. theory of the parasitic systems self-regulation, the conclusion is made about the expediency of using a factor approach for epidemiological forecasting of morbidity in organized collectives. It is proposed to use the state of individual resistance as one of the main factors determining the epidemic well-being of organized collectives.The results of the development and testing of an electronic database that allows epidemiological surveillance of the morbidity of trainees and its linear prediction are presented.
Cost-effectiveness of meningococcal vaccination of infants in the Russian Federation
Authors: Rudakova A. V. , Vilnits A. A. , Kharit S. M. , Lobzin Yu. V. 
Published: December 2021

Generalized forms of invasive meningococcal desease (IMD) are very dangerous because they have a high mortality rate.The aim of the workwas to assess the cost-effectiveness of meningococcal vaccination of infants with the 4-valent MenACWY-D conjugate vaccine in the Russian Federation.Material and methods. Cost-effectiveness analysis based on epidemiological data for the Russian Federation was carried out by a modeling method with a horizon of 80 years from the position of the healthcare system and taking into account the social perspective. Vaccination costs were calculated on the basis of the registered price of the vaccine, including VAT, the costs of GFMI therapy and patient rehabilitation – based on the compulsory medical insurance tariffs in St. Petersburg for 2021. Indirect costs due to temporary disability of patients’ parents, disability of patients and premature death were estimated by the lost GDP. In the base case, costs were discounted by 3,5% per year, life expectancy – by 1,5% per year.Results. Given the assumptions made, the average lifetime burden of a child’s illness is 17,556 million rubles. (no discounting). In the base case, the incremental cost per LYG from the payer perspective – 7,821 million rubles, and from the social perspective – 3,328 million rubles. Incremental cost per QALY – 5,350 million rubles and 2,277 million rubles, respectively. The most important factors that have a significant impact on the cost-effectiveness of vaccination are the incidence of IMD, the price of the vaccine, and the value of the discounting of costs and life expectancy.Conclusions. Given the assumptions made, meningococcal vaccination of infants with 4-valent meningococcal vaccine can be considered as a viable option.
Role of Microenvironment in Ovarian Tumourisation
Authors: Khalikova L. V. , Shevlyuk N. N. , Gantsev Sh. Kh. , Khalikov A. A. , Khasanova I. R. 
Published: December 2021

Background. Metastasis is a formidable complication of malignant neoplasms, with therapy not always effective in advanced malignancy. Metastasis is a multistep process involving the cancer cell detachment from primary tumour, intravasation, extravasation and invasion into the target organ. Early metastasis stages are well understood, whilst the impact of tumour microenvironment on the disease progression and advancement remains a matter of debate.Aim. An immunohistochemical study of the adaptive and reactive properties of greater omentum with metastatic involvement in ovarian cancer.Materials and methods. We examined greater omentum tissue samples from 40 patients with verifi ed stage 3a and b ovarian cancers. For light microscopy, samples were fi xed in 10 % formalin, dehydrated, paraffi n-embedded and stained with Mayer’s haematoxylin and eosin. Immunohistochemical assays used monoclonal antibodies against CD7, CD4, CD8, CD 68, VEGF, D2-40 and CD44 proteins. Statistical data analysis was performed with Statistica v. 7.0 soft ware.Results and discussion. Analyses of the greater omentum tissues revealed cases of leucocyte-bank encapsulation of metastatic foci. Higher CD7+ and CD8+ cell counts were observed in encapsulation, possibly influencing the greater omentum reactive and adaptive properties. Higher CD44-expressing cell counts were also detected in greater omentum samples lacking encapsulation. Angiogenesis marker-expressing cells (e.g., VEGF and CD34) predominated in greater omentum tissues lacking leucocyte-bank encapsulation of metastatic foci.Conclusion. Events in tumour microenvironment may be indicative of a preserved or reduced organ adaptivity, the latter facilitating disease progression.
Surgical Treatment of Gastric Malignancy in Chronic Kidney Disease Patient with Long-Term Haemodialysis
Authors: Kovalenko N. V. , Ivanov A. I. , Galeev S. R. , Zhavoronkova V. V. , Nikolaev A. U. , Postolov M. P. , Suvorov V. A. , Klimchenko A. A. 
Published: December 2021

Background. Gastric cancer is the world 5th top malignancy, with treatment success largely conditioned by comorbidity. Patients with end-stage renal failure developed with chronic kidney disease could not expect a specialty cancer treatment before the advent of long-term haemodialysis.Aim. A case description of successful perioperative therapy and surgery in a long-term haemodialysis patient performed by a multi-specialty team of oncologists and transplantologists.Materials and methods. We case-illustrate surgical treatment options in a gastric cancer patient with long-term haemodialysis.Results and discussion. A specialty oncological treatment of end-stage renal failure patients requiring long-term haemodialysis is a complex multidisciplinary task feasible in hospitals equipped for different haemodialysis regimens. The treatment plan should be laid out by a multi-specialty team, as chronic kidney disease influences the choice of the drug class, dosage and administration mode. Moreover, such patients need laboratory (control of acid-base balance, haemoglobin, electrolytes, creatinine and urea) and clinical (body weight, liquid balance, etc.) monitoring.Conclusion. Perioperative management studies in gastric cancer and chronic kidney disease-comorbid patients under long-term haemodialysis is a promising area of combining eff ort in oncology and transplantation science. Further research is needed in this topic for data enrichment and analysis in complex comorbidity patients.