bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable utilisation of water treatment residue as a porous geopolymer for iron removal from groundwater
Authors: Pachana Pumipat K. , Rattanasak Ubolluk , Nuithitikul Kamchai , Jitsangiam Peerapong , Chindaprasirt Prinya 
Published: August 2021

Abstract
Raw water is significant resources for industrial water usage, but this water is not directly suitable for use due to the presence of contaminants. Therefore, pre-treatment is essential. In addition, the presence of iron (Fe) and manganese (Mn) in groundwater can result in a reddish-brown colour and undesirable taste and odour. The treatment generates water treatment residue (WTR) which consists of silt, clay and undesirable components. Most WTR is conventionally disposed of in landfill. A number of expensive and complex technologies are being used for the removal of such iron and manganese. Due to the high Al2O3 and SiO2 content in WTR, the use of WTR-based geopolymers for Fe/Mn removal is proposed in this study. With the availability of free alkali in the geopolymer framework, the OH-releasing behaviour of the WTR-based geopolymer was investigated by the precipitation of Fe(II) ion. The WTR-based geopolymer was calcined at 400°C and 600°C to obtain a strong geopolymer matrix with the ability to remove Fe/Mn ions. The results show that the WTR-based geopolymer has the potential to remove Fe from Fe-contaminated water. Hydroxide ions are released from the geopolymer and form an Fe(OH)3 precipitate. A calcination temperature of 400°C provides total removal of the Fe after 24 h of immersion. In addition, the existence of Fe(OH)3 helps to coprecipitate the Mn(OH)2 in the Fe/Mn solution leading to a significant reduction of Mn from the solution. The pH value and retention time play an important role in the final metal concentration. The final pH of the solution is close to 8.5, which is the recommended value for boiler water. This method offers an alternative use of WTR in making a porous geopolymer for groundwater Fe removal using a simple method.
Comparative Analysis of Machine Learning Methods for Non-Intrusive Indoor Occupancy Detection and Estimation
Authors: Aliero Muhammad S. , Pasha Muhammad F. , Toosi Adel N. , Ghani Imran , Sadiq Ali S. , Asif Muhammad 
Published: August 2021

Abstract
Occupancy-driven application research has been active research for a decade that focuses on improving or replacing new building infrastructure to improve building energy efficiency. Existing approaches for HVAC energy saving are putting more emphasis on occupancy detection, estimation, and localization to trade-off between energy consumption and thermal comfort satisfaction. In a non-intrusive approach, various sensors, actuators, and analytic data methods are commonly used to process data from occupant surroundings and trigger appropriate action to achieve the task. However, the performance of the non-intrusive approach reported in the literature is relatively poor due to the lack of quality of dataset used in model training and expropriate choice of machine learning model. This study proposed a non-intrusive approach that to improve the collection and quality of dataset using data pre-processing. The study collected a training dataset using various sensors installed in the building and developed a model using five machine learning models to determine occupant’s presence and estimate their number in the building. The proposed solution is tested in the living room with a prototype system integrated with various sensors designed to obtain occupant surrounding environmental datasets. The model’s prediction results obtained indicate that it is possible for the proposed solution to obtain data, process, and predict the occupant number with high accuracy (73.6 -99.7% using random forest).
Analysis on Ethiopia’s Revealed Comparative Advantage and Its Structural Transformation
Authors: Hunegnaw Fetene Bogale 
Published: August 2021

Abstract
This study examines Ethiopia’s structural transformation by using the revealed comparative advantage approach using export data for years 1996–2018. Primary and low technology manufactured products have comparative advantage over other product groups for the periods 1996 to 2018. However, there is an improvement in all manufactured product categories except except low technology manufactured products (textile, garment and footwear) and resource-based manufactured goods. Thus, based on revealed comparative, structural transformation has occurred in the Ethiopian economy over the last decades but it is very insignificant. Hence, Ethiopia reveals strong comparative advantage in export of primary products, it is important to add value to these products for higher export earnings.
Clinical and Genetic Analyses and Treatment Outcomes of Patients with Lateralized Overgrowth
Authors: Kim Yoon-Myung , Lee Yena , Choi Yunha , Choi In-Hee , Heo Sun Hee , Choi Jung Min , Do Hyo-Sang , Jang Ja-Hyun , Yum Mi-Sun , Yoo Han-Wook , Lee Beomhee 
Published: August 2021

Abstract
Background: The genetic features and management of lateralized overgrowth have been elusive. This study was performed to investigate the genetic profiles and outcomes of propranolol- or alpelisib-treated patients with lateralized overgrowth. Methods: Fifteen patients with lateralized overgrowth were enrolled. Clinical features and whole-body magnetic resonance imaging (WB-MRI) findings were evaluated. Deep sequencing with a customized gene panel of affected tissue and peripheral white blood cells was performed. Propranolol was administered and clinical outcomes were examined. The PIK3CA inhibitor alpelisib was administered via a managed access program. Results: Genetic testing identified PIK3CA (n=7, 46.7%), KRAS (n=2, 13.3%), PTEN (n=1, 6.7%), MAP2K3 (n=1, 6.7%), GNAQ (n=1, 6.7%), TBC1D4 (n=1, 6.7%), and TEK (n=1, 6.7%) mutations. Propranolol was administered in 12 patients, and 7 experienced limited improvement of symptoms. Alpelisib was administered in two patients with a PIK3CA mutation, and the WB-MRI after 1 year of treatment showed a reduction in proliferated masses. Conclusions: Deep sequencing identified diverse genetic features of lateralized overgrowth. Propranolol could be used as an adjuvant therapy for reducing vascular symptoms, but targeted therapy with a PIK3CA inhibitor would be the primary therapeutic strategy for PIK3CA-related overgrowth syndrome.
A Study of Association Between Acromion Types and Shoulder Pathology
Authors: Venkataraman Sagar , Ethiraj Prabhu , Shanthappa Arun Heddur , Vellingiri Kishore 
Published: August 2021

Abstract
Background and aim: Shoulder impingement and rotator cuff tear are commonly seen shoulder pathology. Pathological changes in soft tissue around shoulder can be due to intrinsic degenerative in tendons or extrinsic mechanical compression due to Acromion types. Arthroscopic acromioplasty is still standard procedure done for shoulder impingement pathology and during rotator cuff repair. Our primary objective was to determine acromion types, its prevalence rate with shoulder pathology.Methods: Total 85 patients who met inclusion criteria were included in the study. Acromion types were classified according to Bigliani et al type I acromion has flat undersurface, type II acromion has curved undersurface, type III acromion has hooked undersurface on Supraspinatous outlet view radiographs. Types of Acromion were co-related with shoulder pathology and age group.Results: Out of 85 patients with shoulder pathology 43 patients had impingement shoulder syndrome and 42 patients had rotator cuff tear. Mean age group for impingement shoulder syndrome group was 39.6 years and for rotator cuff tear group was 58.6 years. Overall right shoulder is affected more compared to left shoulder. Type 2 acromion was seen in 64.7% study population and type 1 is seen in 23.5% and type 3 is seen in 11.8%.Conclusions: In our study type 2 acromion is more frequently seen in shoulder pathology involving rotator cuff tear and impingement syndrome. Acromion morphology does not vary with age.
Breath figure templated self-assembly of surface-acylated cellulose nanowhiskers confined as honeycomb films
Authors: Liu Huan , Pang Bo , Zhang Kai 
Published: August 2021

Abstract
The self-assembly of cellulose nanowhiskers (CNWs) in confined geometries provides a powerful method for the fabrication of novel structures. Herein, ordered honeycomb microporous films were first prepared with surface-acylated CNWs (CNWs-SU) through the breath figure method. Resulting films showed highly porous order over large regions and the iridescent color was only displayed by their rims, which is different from traditional dish-cast CNW films showing the iridescent color over the whole area. This is mainly due to the condensation of water droplets forming three-dimensional (3D) geometry, which forced CNWs-SU to self-assemble into cholesteric architectures in confined geometry and resulted in the iridescent color of the rims after drying. The mechanism was further studied by investigating the critical influencing factors, primarily the concentration of CNW-SU suspensions, the relative humidity of the atmosphere and the surface-attached moieties. In particular, CNW-SU suspensions with a concentration of 3 mg/mL at the relative humidity of 75% preferentially formed honeycomb films with uniform pores. Too low or too high concentrations of CNW-SU suspensions or relative humidity are not preferable for uniform porous films. CNWs-SU with further immobilized octadecane or fluoroalkyl groups on their surface strongly affected the formation of uniform porous films because of higher hydrophobicity and accompanying inhomogeneous condensation of water droplets. This work provides a novel method to study the interactions of CNWs beyond the planar geometry and the formation of uniform porous films solely with CNWs with structural colors for diverse potential applications.
PedigreeOnline: a new web server for two-way interactive pedigree drawing
Authors: Chen Ye , Cang Xiaohui 
Published: August 2021

Abstract
Pedigree drawing is of special importance for genetic counseling and research on documenting families with inherited disease. Current pedigree-drawing tools fall into two types: those build pedigree diagrams from input family data, and those provide a graphical interface to draw pedigree directly. Here we merge the two types of programs into one, and release a brand new pedigree-drawing web server, PedigreeOnline. Through introducing a novel pedigree-like-layout (PLL) family data format and taking advantage of HTML5 canvas element in development, this program is able to build two-way interactive connections between family data and graphical interface. Users can work on and switch easily between the graphical interface and the family data window. Currently this web server is compatible with Linkage data format and comma-separated value (CSV) data format. These features make PedigreeOnline a pedigree-drawing tool with outstanding user-friendliness and flexibility. PedigreeOnline is freely accessible for everyone at: http://www.ig.zju.edu.cn/PedigreeOnline/
Long-term effectiveness of the Midwifery Initiated Oral Health-Dental Service Program on maternal oral health knowledge, preventative dental behaviours and the oral health status of children in Australia
Authors: George Ajesh , Kong Ariana , Sousa Mariana , Villarosa Amy , Ajwani Shilpi , Dahlen Hannah , Bhole Sameer , Yaacoub Albert , Srini Ravi , Johnson Maree 
Published: August 2021

Abstract
Background

Early childhood caries remains a public health challenge and many interventions to manage this disease have focused on prevention during early infancy. Promoting oral health during pregnancy may also improve the oral health of children, however, there is limited evidence in Australia. The Midwifery Initiated Oral Health-Dental Service (MIOH-DS) was developed to train midwives to promote maternal oral health and a large trial showed the program substantially improved the oral health status, knowledge and behaviours of pregnant women. This study evaluated the long-term effectiveness of the program (post trial) on maternal oral health knowledge, preventative dental behaviours, and early childhood caries in offspring.
Methods

A prospective cohort study was conducted in three large metropolitan health services in Sydney, Australia. The study followed 204 women and their children three to four years after participating in the original MIOH-DS trial (intervention and control groups). The outcome measures included child dental decay (cariogenic bacteria), and a maternal oral health knowledge and behaviours questionnaire. Descriptive statistics were used to analyse the main outcomes and a regression model was constructed to explore predictors of dental decay among children.
Results

There were no significant differences across the outcome measures between the MIOH-DS participants (mother/child) and control groups except for a small difference in maternal oral health knowledge. Most mothers across both groups demonstrated high oral health knowledge and positive oral health practices, and the regression model found that these outcomes provided a protective effect (low levels of bacteria and dental caries) among children. Some aspects of oral health remained poorly understood by mothers across both groups―the oral health impact of sugary foods and drinks, at-risk feeding practices, and the recommended age for first dental visits.
Conclusions

The long-term impact of the program demonstrates the effectiveness of improving maternal oral health knowledge and preventative behaviours to reduce the risk of early childhood caries, although the specific effect of the MIOH-DS program was not found. Although oral health knowledge was high across participants the findings suggest the need for reinforced education around feeding, diet and dental visiting through postnatal early childhood services to show sustained improvements.
DOCK2 is a Biomarker for Predicting the Prognosis of Lung Adenocarcinoma and Associated with Immune Infiltration
Authors: He Jie , Zhang Tongtong , Sun Jian , Liu Guangnan 
Published: August 2021

Abstract
Background: dedicator of cytokinesis 2 is an atypical guanine exchange factor, which is particularly expressed in hematopoietic cells and modulates the activation along with the migration of immune cells by activating Ras--related C3 botulinum toxin substrate (Rac). Nevertheless, the role of DOCK2 in lung adenocarcinoma (LUAD) remains unclear.Methods: Herein, we performed bioinformatics analysis of lung adenocarcinoma data abstracted from TCGA (The Cancer Genome Altas) and GEO (Gene Expression Omnibus) data resources, and combined with web tools consisting of LinkedOmics, TIMER, and TISIDB. Finally, combined with clinical lung adenocarcinoma samples, we verified the expression of DOCK2 in tissue and its effect on the prognosis of lung adenocarcinoma.Results: In the TCGA lung adenocarcinoma data set, the expression of DOCK2 was down-regulated in tumor tissues and verified in multiple independent cohorts. In addition, the low expression of DOCK2 indicates a poor overall survival(OS) in both TCGA and other GEO data sets and in our clinical samples. COX regression data illustrated that the low expression of DOCK2 was an independent predictor for OS. Functional network analysis shows that DOCK2 participates in immune response through interleukin production, neuroinflammatory response, acquired immune response, leukocyte migration and activation of lymph node cells, and is related to multiple immune-related pathways. Besides, the expression of DOCK2 was remarkably related with many kinds of tumor infiltrating immune cells.Conclusion: combined with bioinformatics analysis and clinical sample verification, our study shows that DOCK2 can independently estimate the prognosis of lung adenocarcinoma and is related to immune infiltration. As a promising prognostic indicator and potential target of immunotherapy, the potential effect of DOCK2 on lung adenocarcinoma and its molecular mechanism are worthy of further discussion.
Health-Related Quality of Life of Chilean Students from Risky Contexts
Authors: Ortiz-Bermúdez Amaranta Úrsula , Sánchez-Sandoval Yolanda 
Published: August 2021

Abstract
Background. The study of Health-Related Quality of Life (HRQoL) is receiving increasing attention, thus facilitating the use of well-being indicators to establish public policies and health programs in contexts of high social risk. It is a subjective assessment that the person makes of their life concerning the cultural context and the normative standards of the person’s society. In contexts where violence, neglect, and abuse exist, a decrease in physical and mental well-being is more likely to be observed in adolescents. The aims of this paper are to evaluate the HRQoL of vulnerable Chilean students and analyze its relationship with socio-family variables, and to compare their HRQoL with the Chilean and European standards of adolescent population. Methods. 246 adolescents (9 to 16 years) from public schools of with a high School Vulnerability Index (SVI) of the Commune of Quilpué (Chile) completed the KIDSCREEN-27 (Physical Well-being, Psychological Well-being, Autonomy and Parent Relation, Social Support and Peers, School Environment, and their parents provided sociodemographic data. Results. The Chilean students of the study showed a significantly lower HRQoL than the comparison European and Chilean populations. Girls and older participants had worse HRQoL. Concerning family characteristics, children of mothers with higher educational levels had greater well-being. Other socio-family characteristics are described in depth in the work. Conclusion. These findings could be considered for the planning of psychoeducational programs in schools with high SVI.
Outcomes after Rotation Scarf with Akin Osteotomy for Severe Hallux Valgus
Authors: Xie Wenyong , Lu Hao , Li Guicheng , Yuan Yusong , Liu Yijun , Xu Hailin 
Published: August 2021

Abstract
Background: Hallux valgus is one of the most common foot deformities. Surgical treatment is the optimal choice for moderate to severe hallux valgus deformity. Rotation scarf with Akin osteotomy has become increasingly popular. The purpose of our study is to evaluate the long-term outcomes of rotation scarf with Akin osteotomy on severe hallux valgus. Methods: We conducted a retrospective study of patients with hallux valgus who underwent surgery using rotation scarf with Akin osteotomy in our hospital between June 2014 and January 2020. Anteroposterior and lateral weightbearing X-ray were performed before and after the operation. The parameters evaluated include (1) the hallux valgus angle (HVA), (2) intermetatarsal angle (IMA), (3) distal metatarsal articular angle (DMAA) and (4) tibial sesamoid position (TSP). A visual analog scale (VAS) was used to evaluate the pain level before and at the last follow-up after the operation. American Orthopaedic Foot & Ankle Society (AOFAS) Forefoot Score were assessed before and at the last follow-up after the operation. Patient satisfaction assessment was also conducted at the time. Results: A total of 42 patients with 50 feet met our inclusion criteria. Average age at the time of surgery was 61 ± 9 years. Follow-up data were obtained in all 42 patients. The average follow-up time was 47.4 ± 20 months. All radiological parameteres including HVA, IMA, DMAA and TSP had statistically significant improvement (p < 0.001). The VAS score and AOFAS score was also statistically significant before operation and at the last follow-up after the operation (p < 0.001). There are 41 (82%) feet in patients were very satisfied or satisfied. Conclusion: Rotation scarf with Akin osteotomy is demonstrated to be safe, effective, and feasible for correcting severe hallux valgus. It can obtain good long-term correction with a low incidence of recurrence and metatarsalgia. Postoperative satisfaction and functional recovery of patients are significantly improved.
The overexpression of FKBP4 in patients with lung adenocarcinoma predicts poor prognosis and tumor progression
Authors: Tian Sha , Wang Shang qing , Zheng Piao , Zhu Xu , Han Huan , Huang Xiao di , Li Jing , Tian Xuefei 
Published: August 2021

Abstract
Background: The FK506-binding protein 4 ( FKBP4 ), a tumor-related gene, plays a vital role in tumorigenesis and cancer progression. The study is aimed to clarify the effect of FKBP4 in lung adenocarcinoma (LUAD). Methods: Relying on The Cancer Genome Atlas (TCGA) cohort, the FKBP4 expression difference between LUAD tissues and non-tumor tissues was first detected, and verified with public tissue microarrays (TMAs), clinical LUAD specimen cohort and Gene Expression Omnibus (GEO) cohort. Then, logistic regression analysis and chi-square test were applied to detect the correlation between FKBP4 expression and clinicopathological parameters. Kaplan-Meier survival analysis and Cox regression model were utilized to evaluate the effect of FKBP4 expression on survival. Signaling pathways related to LUAD were obtained via employing Gene Set Enrichment Analysis (GSEA). Results: The FKBP4 expression level in LUAD samples was dramatically higher than that in non-tumor samples. High FKBP4 expression in LUAD is associated with gender, pathological stage, T classification, lymph node metastasis and distant metastasis. The Kaplan-Meier curve indicated a poor prognosis for LUAD patients with high FKBP4 expression. Multivariate analysis suggested that the high FKBP4 expression was a vital independent predictor of poor overall survival (OS). GSEA showed that a total of 15 signaling pathways were enriched in samples with high FKBP4 expression phenotype. Conclusions: FKBP4 may be an oncogene in LUAD, and is promised to become a prognostic indicator and therapeutic target for LUAD.