bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Model Pembelajaran 5E untuk Meningkatkan Keterampilan Proses Sains Biologi Peserta Didik Kelas XI SMA
Authors: Jayanti Mei Indra 
Published: October 2021

Rendahnya kualitas pendidikan di Indonesia yang diketahui melalui data dari tes PISA 2015 merupakan masalah besar yang perlu diselesaikan. Model pembelajaran 5E adalah salah satu model pembelajaran yang sesuai dengan paradigma konstruktivisme sehingga siswa dapat membangun pengetahuan mereka sendiri melalui pengalaman langsung selama pembelajaran, dengan begitu keterampilan proses sains peserta didik dapat dibentuk. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh model pembelajaran 5E dalam meningkatkan keterampilan proses sains biologi peserta didik kelas XI SMA. Jenis penelitian ini adalah penelitian eksperimental semu. Populasi dalam penelitian ini adalah seluruh peserta didik kelas XI MIA SMAN 4 Kota Bima pada semester genap tahun ajaran 2018/2019 yang berjumlah 4 (empat) kelas. Sampel diperoleh melalui teknik simple random sampling. Sampel penelitian terdiri dari 2 (dua) kelas, yaitu kelas eksperimen dan kelas kontrol. Data keterampilan proses sains diperoleh dengan menggunakan lembar tes keterampilan proses sains. Analisis data dibantu dengan perangkat lunak SPSS 20 for windows menggunakan uji t. Hasil analisis data menunjukkan bahwa model pembelajaran 5E dapat mempengaruhi keterampilan proses sains peserta didk kelas XI SMA dengan hasil pengujian menggunakan uji t menunjukkan nilai sig. 0,033 <0,05.
Pengaruh Pemberian Tugas Terstruktur Terhadap Kemampuan Berpikir Kritis Peserta Didik Kelas VII SMP Negeri 11 Kota Bima
Authors: Fahruddin Fahruddin , Herman Herman , Nasir Muh. , Nehru Nehru 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh pemberian tugas terstruktur terhadap kemampuan berpikir kritis peserta didik kelas VII SMP Negeri 11 Kota Bima tahun pelajaran 2019/2020. Populasi dalam penelitian ini yaitu siswa kelas VII SMPN 11 Kota Bima yang berjumlah 117 peserta didik. Sampel dalam penelitian ini diambil dengan teknik claster sampling. Kelas VIIA sebanyak 28 orang sebagai kelompok eksperimen menggunakan metode pemberian tugas terstruktur dan kelas VIIB sebanyak 28 orang sebagai kelompok kontrol tidak menggunakan menggunakan metode ceramah. Penelitian ini termasuk penelitian Quasi Experiment melalui dengan desain pretest-posttest control group design. Instrumen yang digunakan berupa soal tes uraian dan lembar observasi. Tehnik analisis data menggunakan t-test. Hasil penelitian menunjukan bahwa terdapat pengaruh metode pemberian tugas terstruktur terhadap kemampuan berpikir kritis peserta didik kelas VII SMPN 11 Kota Bima tahun pelajaran 2019/2020, dengan nilai t-hitung 3,41 < t-tabel 2,052
PENGARUH LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN
Authors: Mukhsin Zainuddin , Fikri Buana Bima , Wahyuni Wahyuni 
Published: October 2021

Tujuan penelitian ini untuk mengetahui pengaruh lingkungan kerja terhadap kinerja karywawan. Populasi dalam penelitian ini adalah seluruh karyawan Hotel Marina Kota Bima sebanyak 53 orang. Metode pengumpulan data yang digunakan adalah metode kuesioner (angket) dan dokumentasi. Metode analisis data yang digunakan dalam penelitian ini adalah metode analisis deskripsi persentase dan regresi linier berganda. Berdasarkan hasil penelitian diperoleh persamaan regresi linier sederhana Ŷ= 23,857 + 0,94 X. Dengan menggunakan SPSS. Hasil uji Hipotesis secara parsial (uji t) diperoleh t hitung dari variabel lingkungan kerja sebanyak 2.207 dimana probabilitas lebih kecil dari 0,05 maka hipotesis diterima. Koefisien determinasi (Adjusted R2) sebesar 0,376, hal ini berarti 37,6% kinerja karyawan Hotel Marina Kota Bima dipengaruhi oleh lingkungan kerja. Kesimpulan penelitian bahwa lingkungan kerja masuk dalam kategori baik, dan kinerja karyawan Hotel Marina Kota Bima masuk dalam kategori baik. Lingkungan kerja memiliki pengaruh terhadap kinerja karyawan dengan kontribusi sebesar 8,88%.
Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells
Authors: Taddese Rahwa , Roelofs Rian , Draper Derk , Wu Xinqun , Wu Shaoguang , Swinkels Dorine W. , Tjalsma Harold , Boleij Annemarie 
Published: October 2021

ObjectiveThe opportunistic pathogen Streptococcus gallolyticus is one of the few intestinal bacteria that has been consistently linked to colorectal cancer (CRC). This study aimed to identify novel S. gallolyticus-induced pathways in colon epithelial cells that could further explain how S. gallolyticus contributes to CRC development.Design and ResultsTranscription profiling of in vitro cultured CRC cells that were exposed to S. gallolyticus revealed the specific induction of oxidoreductase pathways. Most prominently, CYP1A and ALDH1 genes that encode phase I biotransformation enzymes were responsible for the detoxification or bio-activation of toxic compounds. A common feature is that these enzymes are induced through the Aryl hydrocarbon receptor (AhR). Using the specific inhibitor CH223191, we showed that the induction of CYP1A was dependent on the AhR both in vitro using multiple CRC cell lines as in vivo using wild-type C57bl6 mice colonized with S. gallolyticus. Furthermore, we showed that CYP1 could also be induced by other intestinal bacteria and that a yet unidentified diffusible factor from the S. galloltyicus secretome (SGS) induces CYP1A enzyme activity in an AhR-dependent manner. Importantly, priming CRC cells with SGS increased the DNA damaging effect of the polycyclic aromatic hydrocarbon 3-methylcholanthrene.ConclusionThis study shows that gut bacteria have the potential to modulate the expression of biotransformation pathways in colonic epithelial cells in an AhR-dependent manner. This offers a novel theory on the contribution of intestinal bacteria to the etiology of CRC by modifying the capacity of intestinal epithelial or (pre-)cancerous cells to (de)toxify dietary components, which could alter intestinal susceptibility to DNA damaging events.
Vitamin K Epoxide Reductase Complex Subunit 1-Like 1 (VKORC1L1) Inhibition Induces a Proliferative and Pro-inflammatory Vascular Smooth Muscle Cell Phenotype
Authors: Aksoy Adem , Al Zaidi Muntadher , Repges Elena , Becher Marc Ulrich , Müller Cornelius , Oldenburg Johannes , Zimmer Sebastian , Nickenig Georg , Tiyerili Vedat 
Published: October 2021

Background: Vitamin K antagonists (VKA) are known to promote adverse cardiovascular remodeling. Contrarily, vitamin K supplementation has been discussed to decelerate cardiovascular disease. The recently described VKOR-isoenzyme Vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) is involved in vitamin K maintenance and exerts antioxidant properties. In this study, we sought to investigate the role of VKORC1L1 in neointima formation and on vascular smooth muscle cell (VSMC) function.Methods and Results: Treatment of wild-type mice with Warfarin, a well-known VKA, increased maladaptive neointima formation after carotid artery injury. This was accompanied by reduced vascular mRNA expression of VKORC1L1. In vitro, Warfarin was found to reduce VKORC1L1 mRNA expression in VSMC. VKORC1L1-downregulation by siRNA promoted viability, migration and formation of reactive oxygen species. VKORC1L1 knockdown further increased expression of key markers of vascular inflammation (NFκB, IL-6). Additionally, downregulation of the endoplasmic reticulum (ER) membrane resident VKORC1L1 increased expression of the main ER Stress moderator, glucose-regulated protein 78 kDa (GRP78). Moreover, treatment with the ER Stress inducer tunicamycin promoted VKORC1L1, but not VKORC1 expression. Finally, we sought to investigate, if treatment with vitamin K can exert protective properties on VSMC. Thus, we examined effects of menaquinone-7 (MK7) on VSMC phenotype switch. MK7 treatment dose-dependently alleviated PDGF-induced proliferation and migration. In addition, we detected a reduction in expression of inflammatory and ER Stress markers.Conclusion: VKA treatment promotes neointima formation after carotid wire injury. In addition, VKA treatment reduces aortal VKORC1L1 mRNA expression. VKORC1L1 inhibition contributes to an adverse VSMC phenotype, while MK7 restores VSMC function. Thus, MK7 supplementation might be a feasible therapeutic option to modulate vitamin K- and VKORC1L1-mediated vasculoprotection.
Association of Thyroid-Stimulating Hormone (TSH) Levels With the Prognosis of Patients Undergoing Heart Transplantation: A Retrospective Study
Authors: Wei Jiajie , Zhou Yingsheng 
Published: October 2021

Purpose: To investigate the impact of TSH levels using a more stringent cutoff of subclinical hypothyroidism (i.e., TSH &gt; 2.5 mIU/L) on the short-term complications and long-term prognosis in patients who underwent heart transplantation (HTx).Methods: This is a retrospective study of consecutive patients with end-stage heart failure (HF) who underwent HTx. They were divided into three groups: thyroid-stimulating hormone (TSH) ≤ 2.50 mIU/L (L-TSH), 2.50 &lt; TSH ≤ 4.91 mIU/L (M-TSH), and TSH &gt; 4.91 mIU/L (H-TSH). The outcomes are all-cause death and cardiogenic death.Results: There are 63 (70%) males and 27 (30%) females. Nine (10%) patients died within 1 month after surgery, including five cardiogenic deaths. By 1 year, a total of 19 patients total were dead. The survival rate in the M-TSH group was significantly higher than that of the L-TSH group (P = 0.017). After adjusted by variables of sex, age, BMI, diabetes history, hypertension history, the multivariable Cox analysis showed that body mass index (HR = 0.804, 95%CI: 0.680–0.951, P = 0.011), and L-TSH (HR = 8.757, 95%CI: 1.786–42.948, P = 0.007 vs. M-TSH), and H-TSH (HR = 6.427, 95%CI: 1.137–36.327, P = 0.035 vs. M-TSH) were independently associated with all-cause death. The multivariable Cox analysis showed that body mass index (HR = 0.703, 95%CI: 0.564–0.878, P = 0.002), and L-TSH (HR = 17.717, 95%CI: 1.907–164.607, P = 0.011 vs. M-TSH) were independently associated with cardiogenic death.Conclusion: For patients with end-stage HF undergoing HTx, low and high baseline TSH levels are independently associated with 1-year all-cause death and low baseline TSH levels with cardiogenic death.
Methane in Lakes: Variability in Stable Carbon Isotopic Composition and the Potential Importance of Groundwater Input
Authors: Schenk Jonathan , Sawakuchi Henrique O. , Sieczko Anna K. , Pajala Gustav , Rudberg David , Hagberg Emelie , Fors Kjell , Laudon Hjalmar , Karlsson Jan , Bastviken David 
Published: October 2021

Methane (CH4) is an important component of the carbon (C) cycling in lakes. CH4 production enables carbon in sediments to be either reintroduced to the food web via CH4 oxidation or emitted as a greenhouse gas making lakes one of the largest natural sources of atmospheric CH4. Large stable carbon isotopic fractionation during CH4 oxidation makes changes in 13C:12C ratio (δ13C) a powerful and widely used tool to determine the extent to which lake CH4 is oxidized, rather than emitted. This relies on correct δ13C values of original CH4 sources, the variability of which has rarely been investigated systematically in lakes. In this study, we measured δ13C in CH4 bubbles in littoral sediments and in CH4 dissolved in the anoxic hypolimnion of six boreal lakes with different characteristics. The results indicate that δ13C of CH4 sources is consistently higher (less 13C depletion) in littoral sediments than in deep waters across boreal and subarctic lakes. Variability in organic matter substrates across depths is a potential explanation. In one of the studied lakes available data from nearby soils showed correspondence between δ13C-CH4 in groundwater and deep lake water, and input from the catchment of CH4via groundwater exceeded atmospheric CH4 emissions tenfold over a period of 1 month. It indicates that lateral hydrological transport of CH4 can explain the observed δ13C-CH4 patterns and be important for lake CH4 cycling. Our results have important consequences for modelling and process assessments relative to lake CH4 using δ13C, including for CH4 oxidation, which is a key regulator of lake CH4 emissions.
A Genetic Algorithm–Assisted Deep Neural Network Model for Merging Microwave and Infrared Daily Sea Surface Temperature Products
Authors: Xiao Changjiang , Hu Chuli , Chen Nengcheng , Zhang Xiang , Chen Zeqiang , Tong Xiaohua 
Published: October 2021

Sea surface temperature (SST) is an important factor in the global ocean–atmosphere system, being vital in a variety of climate analyses and air–sea interaction research studies. However, estimating daily SST with both high precision and high spatial completeness remains a challenge. This article attempts to solve this problem by merging two complementary daily SST products, that is, the 25 km-resolution Advanced Microwave Scanning Radiometer for EOS (AMSR-E) SST and 4 km-resolution Moderate Resolution Imaging Spectroradiometer (MODIS) SST, using a genetic algorithm–assisted deep neural network model (GA-DNNM). The merged SST with a spatial resolution of 4 km and a temporal resolution of 1 day is achieved. Experiments in the Asia and Indo-Pacific Ocean (AIPO) region in 2005 were conducted to demonstrate the feasibility and advantages of the proposed method. Results showed that the spatial coverages of the original MODIS SST and AMSR-E SST are ranging from 25.0 to 48.1%, and 31.5 to 47.6%, respectively, while the merged SST achieves a spatial coverage ranging from 56.1 to 73.1%, with improvements ranging from 50.2 to 131.7% relative to the original MODIS SST. Comparisons with drifting buoy observations indicate that the merged SST is accurate, with an average bias of 0.006°C and an average RMSE of 0.502°C, in places where the MODIS SST data are missing before being merged in the AIPO area, and with an average bias of −0.082 °C, and an average RMSE of 0.603°C for the merged SST in the whole study area.
Prediction of Clinical Deep Brain Stimulation Target for Essential Tremor From 1.5 Tesla MRI Anatomical Landmarks
Authors: Engelhardt Julien , Cuny Emmanuel , Guehl Dominique , Burbaud Pierre , Damon-Perrière Nathalie , Dallies-Labourdette Camille , Thomas Juliette , Branchard Olivier , Schmitt Louise-Amélie , Gassa Narimane , Zemzemi Nejib 
Published: October 2021

Background: Deep brain stimulation is an efficacious treatment for refractory essential tremor, though targeting the intra-thalamic nuclei remains challenging.Objectives: We sought to develop an inverse approach to retrieve the position of the leads in a cohort of patients operated on with optimal clinical outcomes from anatomical landmarks identifiable by 1.5 Tesla magnetic resonance imaging.Methods: The learning database included clinical outcomes and post-operative imaging from which the coordinates of the active contacts and those of anatomical landmarks were extracted. We used machine learning regression methods to build three different prediction models. External validation was performed according to a leave-one-out cross-validation.Results: Fifteen patients (29 leads) were included, with a median tremor improvement of 72% on the Fahn–Tolosa–Marin scale. Kernel ridge regression, deep neural networks, and support vector regression (SVR) were used. SVR gave the best results with a mean error of 1.33 ± 1.64 mm between the predicted target and the active contact position.Conclusion: We report an original method for the targeting in deep brain stimulation for essential tremor based on patients' radio-anatomical features. This approach will be tested in a prospective clinical trial.
Association Analysis of HIMP and SHIMP Quantitative Parameters in Patients With Vestibular Neuritis and Healthy Participants
Authors: Chen Feiyun , Chen Zichen , Zhang Yuzhong , Wei Xinyu , Zhao Huandi , Hu Juan , Cheng Ying , Ren Xiaoyong , Zhang Qing 
Published: October 2021

Background: The Head Impulse Paradigm (HIMP) and Suppression Head Impulse Paradigm (SHIMP) are objective, quantitative methods that directly test the vestibulo-ocular reflex (VOR) and are increasingly becoming a standard in evaluating patients with vestibular disorders.Objective: The main objective was to assess the correlations between HIMP and SHIMP parameters in patients with superior vestibular neuritis (VN) and healthy participants. Additionally, the correlations between the parameters of each method were analyzed.Methods: A retrospective cohort, non-randomized study was designed. HIMP and SHIMP were performed on 40 patients with VN and 20 healthy participants (40 ears). HIMP and SHIMP parameters were measured and calculated. Pearson's or Spearson's correlations were used to establish the associations among them.Results: A strong positive correlation was found between HIMP and SHIMP gain (Pearson's r = 0.957, p = 0.000), while strong negative correlations were detected between HIMP and SHIMP saccade amplitudes (r = −0.637, p = 0.000) and percentages of overt saccades (r = −0.631, p = 0.000). In HIMP, strong and moderate positive correlations were identified between gain and saccade amplitude (R2 = 0.726, p = 0.000) and gain and saccade percentage (R2 = 0.558, p = 0.000), respectively. By contrast, an extremely weak positive correlation was observed between gain and latency (R2 = 0.053, p = 0.040). In SHIMP, strong and moderate positive correlations were found between gain and saccade percentage (R2 = 0.723, p = 0.000) and gain and saccade amplitude (R2 = 0.525, p = 0.000), respectively, but no correlation was detected between gain and latency (R2 = 0.006, p = 0.490).Conclusions: HIMP and SHIMP-related parameters were highly correlated (inter-method). Within each method (intra-method), moderate to strong correlations in VOR assessment were observed. These results further contribute to our understanding of the relationship between HIMP and SHIMP as well as to the diagnosis.
Weekly Paclitaxel, Carboplatin, and Cetuximab as First-Line Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma for Patients Ineligible to Cisplatin-Based Chemotherapy: A Retrospective Monocentric Study in 60 Patients
Authors: Carinato Hélène , Burgy Mickaël , Ferry Régine , Fischbach Cathie , Kalish Michal , Guihard Sébastien , Brahimi Youssef , Flesch Henri , Bronner Guy , Schultz Philippe , Frasie Véronique , Thiéry Alicia , Demarchi Martin , Petit Thierry , Jung Alain C. , Wagner Pierre , Coliat Pierre , Borel Christian 
Published: October 2021

ObjectiveFor most patients suffering from recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC), chemotherapy is the main option after considering surgery and reirradiation. Cetuximab combined with a platinum-fluorouracil regimen (EXTREME) has been the standard of care for over a decade. Nevertheless, a significant number of patients remain unfit for this regimen because of age, severe comorbidities, or poor performance status. The aim of this study is to investigate an alternative regimen with sufficient efficacy and safety.MethodsWe reviewed retrospectively the medical charts of all patients treated with paclitaxel, carboplatin, and cetuximab (PCC) at our institution. Eligibility criteria were as follows: first-line R/M-HNSCC of the oral cavity, oropharynx, hypopharynx, or larynx not suitable for local therapy, cisplatin, and/or 5-FU ineligibility, ECOG-PS: 0–2. PCC consisted of paclitaxel 80 mg/m2, carboplatin AUC 2, and cetuximab at an initial dose of 400 mg/m2 then 250 mg/m2, for 16 weekly administrations followed by cetuximab maintenance for patients for whom a disease control was obtained. The primary endpoint was overall survival (OS), and secondary endpoints were overall response rate (ORR), progression free survival (PFS), and safety.ResultsWe identified 60 consecutive patients treated with PCC between 2010 and 2016 at our institution. Thirty-one patients (52%) were ECOG-PS 2. Fifty-five patients (92%) were cisplatin ineligible. ORR was 43.3% (95% CI, 30.8–55.8), and disease control rate was 65% (95% CI, 52.9–77.1). With a median follow-up of 35.7 months (IQR 28.6–48.8), median PFS was 5.8 months (95% CI, 4.5–7.2), and median OS was 11.7 months (95% CI, 7.5-14.8). For ECOG-PS 0–1 patients, median OS was 14.8 months (95% CI, 12.2–21.7) while it was only 7.5 months (95%CI: 5.5-12.7) for ECOG-PS 2 patients (p &lt; 0.04). Grades III–IV toxicities occurred in 30 patients (50%). Most toxicities were hematologic. Six patients (10%) had febrile neutropenia. Nonhematologic toxicities were reported such as cutaneous toxicities, neuropathy, infusion-related reactions, or electrolyte disorders.ConclusionThe weekly PCC regimen seems to be an interesting option in cisplatin-unfit patients. This study shows favorable PFS and OS when compared with what is achieved with the EXTREME regimen and a high controlled disease rate with predictable and manageable toxicities even in the more fragile population.
Single-Center Evaluation of Treatment Success Using Two Different Protocols for MRI–Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer
Authors: Hatiboglu Gencay , Popeneciu Valentin , Bonekamp David , Burtnyk Mathieu , Staruch Robert , Distler Florian , Radtke Jan Philipp , Motsch Johann , Schlemmer Heinz Peter , Pahernik Sascha , Nyarangi-Dix Joanne 
Published: October 2021

ObjectivesTo assess differences in 24-month oncologic and functional outcomes in men with low to intermediate-risk prostate cancer treated with MRI-guided transurethral ultrasound ablation (TULSA) using intentionally conservative versus intensified treatment parameters.Patients and MethodsPatients from a single center involved in two multicenter trials were included in this analysis. This included 14 of 30 patients with Gleason 3 + 3 from a Phase I study using intentionally conservative treatment parameters, and 15 of 115 patients with Gleason ≤ 3 + 4 from a pivotal study using intensified parameters. Follow-up data compared across these cohorts included 12-month biopsy and MRI for all patients, and 24-month PSA, micturition and quality of life (IIEF, IPSS, IPSS-QOL). The prognostic value of baseline parameters and PSA kinetics on 12-month histological recurrence was evaluated by logistic regression.Results12-month biopsy revealed clinically significant residual disease in 4 (29%) and 2 (14%) patients from the Phase I and pivotal studies, respectively. PSA nadir was 0.7 ng/ml for Phase I and 0.5 ng/ml for pivotal study patients. Patient age at diagnosis, use of MRI fusion/systematic prostate biopsy, number of obtained cores at initial biopsy, PSA course, and PSA nadir were identified as prognostic factors for treatment success. All but one patient from each cohort maintained erection firmness sufficient for penetration. No cases of pad use were reported at 24 months. There were no Grade 4 or higher adverse events, and no late toxicity related to the procedure.ConclusionTwo-year follow-up demonstrated the efficacy of TULSA for the treatment of localized prostate cancer, and the durability of PSA and functional outcomes. Intensifying treatment parameters in the pivotal trial had no impact on safety or functional outcomes through 24 months, while reducing the recurrence rate for clinically significant disease. Careful patient selection by MRI fusion/systematic prostate biopsy and adequate follow-up through routine 12-month biopsy are recommended.