bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the Formation of Humoral Immunity in Individuals with Various Clinical Manifestations of COVID-19
Authors: Platonova T. A. , Golubkova2 A. A. , Karbovnichaya E. A. , Smirnova S. S. 
Published: March 2021

Relevance In the context of the new coronavirus infection (COVID-19) pandemic, research on the formation of an immune response to SARS-CoV-2 in patients with various clinical forms of this infection is of particular relevance, which is important for understanding the degree of their participation in the formation of population immunity and assessing individual immunity to SARS-CoV-2 in the future. Aim of the study was to analyze the timing of the formation of specific antibodies to SARS-CoV-2 and the duration of their preservation in patients with a new coronavirus infection. Materials and methods. The timing of the formation of specific antibodies of three classes (IgA, IgM and IgG) to SARS-CoV-2 in 218 patients was evaluated in the first days of the disease. Subsequently, they were re-examined at various times from the onset of the disease, from one to four times (a total of 321 control points). To assess the duration of preservation of antibodies to COVID-19 in patients who were ill, a prospective study was organized, in which 368 people participated. Screening for specific class G antibodies was performed every 2–4 weeks, within one to eight months of the onset of clinical manifestations of COVID-19. In total 919 control points. The antibodies were examined by solid-phase enzyme immunoassay using the SARS-CoV-2IgM-ELISA-BEST and SARS-CoV-2-IgG-ELISA-BEST test systems (manufactured by VECTOR-BEST JSC) and Antigma A (manufactured by Generium). Results. In most of the examined individuals, class M and G antibodies began to form from day 10 of the disease, while class A antibodies were detected from day 5. In mild and asymptomatic forms of coronavirus infection, IgG antibodies to SARS-CoV-2 were not formed in most cases, and seroprotection levels correlated with the severity of the disease. The duration of preservation of IgG antibodies could be at least 8 months, but there were isolated cases of their elimination both after COVID-19 in the form of respiratory infection and after interstitial pneumonia. With continuing problems with COVID-19, there were no cases of recurrent disease among individuals who formed G-antibodies (including those who lost them 4-5 months after the disease) during the follow-up period. Conclusion. Thus, according to the results of the study, important materials were obtained on the peculiarities of the formation of a humoral immune response to a new coronavirus infection. However, to fully understand the immune response to SARS-CoV-2, it is necessary to assess the avidity of IgG antibodies or their ability to neutralizing the virus, as well as to study cellular immunity in patients who have had COVID-19 but have not formed antibodies.
Assessment of the Effect of Multidrug Resistance Clostridium difficile Clinical Strains on the Dynamics of Clostridium difficile Infection Rate at Pediatric Oncological Hospital
Authors: Shvydkaya M. G. , Zatevalov A. M. , Dzhandarova D. T. , Mitrokhin S. D. , Orlova O. E. 
Published: March 2021

Relevance. At the children's oncological hospital guidelines to treat patients with several groups of antibiotics at the same time, which ensures the formation of multi-resistant strains of Clostridium difficile, which have a selective advantage for the Clostridium difficile infection developing, and also cause epidemics and /or in associating with an increase in the severity of Clostridium difficile – infection. Aims. Multidrug resistance Clostridium difficile strains and Clostridium difficile infection rate at pediatric oncological hospital. Results. An investigation of the Clostridium difficile resistance strains carried out among children at the children's oncological hospital. 143 toxigenic strains are resistant to moxifloxacin 72.41%, clindamycin 63.72%, rifampicin 35.54%, tetracycline 26.45%, tigecycline 11.42%, vancomycin 4.4%, metronidazole 3.9%. At the same time, the increase multidrug-resistant strains proportion note at the level of 3–4% per year. However, the rate of Clostridium difficile infection among children at the oncological hospital remained at the level of 0.4% to 3.1% with a downward trend. As a result, statistical calculations showed the absence of correlation between multidrug resistance and morbidity. Conclusions. Detection of multidrug-resistant microorganisms among toxigenic Clostridium difficile strains proves the need for further study of this problem in Russia and the advisability of monitoring Clostridium difficile infection rate and multidrug resistance Clostridium difficile strains at pediatric oncological hospitals.
Vaccines against Covid-19: Comparison, Limitations, the Decrease of Pandemic and the Perspective of Viral Respiratory
Authors: Kharchenko E. P. 
Published: March 2021

Relevance. Vaccines are regarded as an effective means for control of the Covid-19 pandemic spreading and their search, analysis, and comparison of their features are important for elucidating the most safe and effective one. Aim. At the end of 2020 two types of vaccines (viral based vaccines and mRNA vaccines) have been licensed to vaccinate. The aim is to compare their features for objective substantiation of their application. Conclusions. As both vaccine types have high effectiveness in inducing antibodies to SARS-Cov-2 (in more 90% recipients) the utility of each vaccine type in blocking the Covid-19 pandemic spreading is beyond doubt. In both vaccine types eventually S protein is the antigen source, and they have limitations for vaccination. In comparison with the vector vaccines mRNA vaccines may induce serious complications, have the least potential to induce trained immunity and can be included into the recipient’s genome. The low frequency of influenza cases in the current epidemic season serves as an of interference between SARS-Cov-2 and influenza viruses. In epidemic seasons after the Covid-19 pandemic coronaviruses may dominate amongst viruses inducing acute respiratory viruses diseases. It is likely that the decline of the Covid-19 case count (in December-January) in Russia is determined by the heterologous collective immunity formed earlier.
Implementasi Manajemen Konflik Dalam Penyelesaian Masalah Pembelajaran Di MI Al Quran Singosari Malang
Authors: Fakhrur Rozi Akhmad 
Published: March 2021

The Teghnologis Graming such a fast and modern in Madrasah Ibtidaiyah Al Quran Singosari Malang was the one of the departement. Either an educational formal and non formal in the islamic boarding school. for answering chace of global the need insight of the word science or heaven. this school the location at Jl ronggowuni candirenggo singosari malang upcoming MI Al Quran the vanture to be school cumate of calm. of need the one methode or conflict of management. the implementation of management to conflict can creat condusife or relationship and culture honour of diversity, can accept critice for of change the honour of another also the creat communication can be opened with to reel a patient.This Reseach was The Qualitatif deeply sharp study cacus. the procedure was taking of data at either observation, interview, and documentation. the analysis data are insed 1. union of data 2. condentation data 3. giving of data 4. verivication. the check original data were credibility and dependability.The goal this research was 1. knowing the implementation conflict of management in MI Al Quran Singosari Malang 2. knowing mandatory head school deeply implementation conflict of management.The conclution was the management conflict at MI Al Quran Singosari Malang the ware not violation. but discoveret the communication between school hear with in teacher another depply to done to confict in the school.
ANALISIS PENGARUH DIKLAT AUDIT INVESTIGATIF TERHADAP PENINGKATAN KOMPETENSI AUDITOR PEMERINTAH PUSAT DAN DAERAH PADA PUSDIKLATWAS BPKP CIAWI- BOGOR
Authors: Slamet Budiman 
Published: March 2021

The role of human resources is very important and major in an organization followed by adjustments to the progress of science and technology, where HR is required to have increased competence. HR is needed who can carry out their duties to achieve organizational goals. Needed directed and planned efforts in the development of human resources, by conducting training (training), education programs in accordance with work programs. There are two types of training programs conducted by the BPKP Training Center, namely the JFA Certification Office (Auditor Functional Position) and the Substantive Technical Training (for example: Investigative Audit Training). The Investigative Audit Training conducted by the BPKP Pusdiklatwas can be carried out independently (PNBP) in the sense of being borne by the Agency sending the participants, or fully borne by the BPKP Pusdiklatwas. This study aims to determine the training participants 'perceptions as well as direct training participants' supervisors on the implementation of investigative audit training and analyze their effects on improving the competence of training participants. Indicators of Education and Training are Conformity with Assignments, Teaching Methods, Lecturers / Instructors, Classroom Facilities, and Training Materials. While competency indicators are Knowledge, Skills, Collaboration, Motivation and Responsibility. The type of data collected in this study consists of primary and secondary data. Data analysis and techniques were performed with regression analysis using SPSS 17.0 software. This study argues that organizing an investigative audit training helps auditors in carrying out the technical implementation of an investigative audit in accordance with the work program of each Central / Regional Inspectorate, as well as increasing competence and developing the profession as an auditor. Training participants 'perceptions as well as direct training participants' conclusions gave the conclusion that, the implementation of investigative training had a real effect on increasing the competence of the Ministry / Institution / Regional Inspectorate auditors. Keywords: Investigative Audit Training; Competency Enhancement Auditor
PENGARUH PENGETAHUAN STANDAR AKUNTANSI KEUANGAN ENTITAS MIKRO KECIL DAN MENENGAH (SAK EMKM), COMPUTER SELF-EFFICACY, DAN FACILITATING CONDITIONS TERHADAP MINAT MENGGUNAKAN APLIKASI AKUNTANSI
Authors: Defillateli Fazrin , Sugiharto Bambang , Umiyati Indah 
Published: March 2021

Small and Medium-Sized Enterprises in Indonesia will continue to grow from year to year, which will support Indonesia's economy. The aim of this research was to find out and analyze the influence of knowledge effects of Financial Accounting Standards of Small and Medium-Sized Enterprises (SMEs), Computer Self-efficacy, and Facilitating Conditions to the intention to using accounting applications Small and Medium-Sized Enterprises (SMEs). The study used three independent variables that are the knowledge of Financial Accounting Standards of Small and Medium-Sized Enterprises (SMEs), Computer Self-efficacy, and Facilitating Conditions, while intention to using accounting applications as a dependent variable. The sample of this research were Small and Medium-Sized Enterprises (SMEs) in Subang Regency, West Java Province. Sampling Incidental of non-probability sampling was used as a sampling method with the total sample of 205 people. Validity, reliability, descriptive analysis, classical assumption test, and multiple regression analysis is used for this study. The results of this research indicate that knowledge of Financial Accounting Standards of Small and Medium-Sized Enterprises (SMEs), Computer Self-efficacy, and Facilitating Conditions have a positive effect to the intention in using either accounting application, the results of tests on each variable or simultaneously. Keyword: Knowledge of Financial Accounting Standards of Small and Medium-Sized Enterprises (SMEs); Computer Self-efficacy; Facilitating Conditions; Intention To Use; Accounting Application
Determinan Niat untuk Melakukan Whistleblowing pada Pemerintah Daerah
Authors: Basri Yesi Mutia , Agustin Merri , Darlis Edfan 
Published: March 2021

This study aims to determine the factors that influence the intentions of government employees to do withlowing. This research examines Effect of personal cost of reporting, level of seriousness of fraud, organizational commitment and professional commitment on the intention to do whistleblowing. The population in this study were all staff / employees at OPD Kuantan Singingi. The sampling method used in this study was the purposive sampling and using the sample of 72 civil servants from 24 different OPD. The results of regression analysis show that personal cost affects the intention to do whistleblowing. 2) the level of seriousness of fraud affects the intention to do whistleblowing. 3) organizational commitment affects the intention to do whistleblowing. 4) professional commitment affects the intention to do whistleblowing. This research has a contribution in reducing fraud in government
STUDY TO DETERMINE THE RELATION BETWEEN HBA1C, LIPID PROFILE AND CRP IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL
Authors: Bhaskar Shubham , Tarafdar Heena Anjum , Kumar Manish , Astik SK 
Published: March 2021

Aim: The aim of this study to determine the relation between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus.
Material and methods: This prospective observational study was carried out in the Department of Medicine in Nalanda Medical College and Hospital at Patna, Bihar India for 1 year. The patients above 30 years with fasting venous blood glucose value equal or more than 100 mg/dl and postprandial glucose >140 mg/dl were include in this study. FBS and PPBS, CRP (immunoturbidimetric method), and HbA1C (ion exchange chromatography using HPLC) lipid profile samples were drawn at entry and at subsequent follow-up with a minimum gap of 3-6 months.
Results: There was no significant difference between gender, age and BMI (p>0.05). FBS and HbA1C were directly correlated. PPBS showed a direct correlation with both HbA1C and CRP in this study. There was a significant positive correlation between CRP and total cholesterol (p<0.05). There was no significant correlation between CRP and LDL cholesterol (p>0.05). There was a negative correlation between HDL cholesterol and CRP. There was significant positive correlation between CRP and triglyceride levels (p<0.05). There was significant correlation between CRP and HbA1C (p<0.05).
Conclusion: We concluded that the CRP is an additional marker of better glycaemic control and also correlates with the dyslipidaemia profile seen in type 2 diabetes mellitus.
Keywords: C-reactive protein, Glycemic control, Hemoglobin A1C, Type 2 diabetes mellitus.
Application of molecular markers for the comprehensive improvement of agro-forestry communities for the development of sustainable agriculture
Authors: Belyaev A. I. , Zaitsev V. G. , Ivaschenko R. Yu. , Popova A. S. , Agapova D. A. , Starukhina A. O. , Zheltova A. A. 
Published: March 2021

Relevance and methods. Analysis of state-of-the-art and perspectives in use of molecular (DNA-based) markers in current horticulture and agroforestry was performed.Results. We showed use of molecular markers for screening of crop varieties with elevated synthesis of human health beneficial metabolites. Molecular markers have not been used to improve varieties of trees yet. Complex use of molecular markers for variety screening and breeding of food crops and forest trees could improve sustainability and productivity of agroforestry systems.
The use of the enzymativeprobiotic additive "Rumit" in feeding lactating cows in the breeding factories of the Vologda region
Authors: Litonina A. S. , Burtseva N. V. , Smirnova Yu. M. , Platonov A. V. , Laptev G. Y. , Dunyashev T. P. 
Published: March 2021

Relevance and methodology. Milk production is effective for producers only in case of high productivity of the farmed livestock. In the prime cost of raw milk, feed costs account for over 60%, in connection with which the main task of modern science is the development of additives and preparations that can improve the use of feed by animals, which will ensure an increase in livestock productivity. The research team of OOO Biotrof has created an experimental preparation "Rumit" — a complex of live bacteria based on cultured strains of cellulolytic bacteria of deer rumen. The effectiveness of the enzymeprobiotic supplement was studied in the breeding farms of the SKHPK collective farm "Peredovoy" and JSC "Plemzavod Rodina" of the Vologda region on lactating cows with a productivity of over 8000 kg of milk per lactation. To conduct the experiment by the method of balanced groups for a complex of economically useful traits and genetic potential, a control and experimental group of 10–12 animals each were formed. Experienced groups were fed with the drug "Rumit" 50 g per head per day during the day.Results. For 90 days of the experiment, the total density of ciliates in the contents of the rumen of the experimental groups increased by 155.9–173.0 thousand ops / ml, and the significant difference with the control was 13.5.9–171.7 thousand ops / ml. The emergence of new genera of ciliates was noted: in the agricultural production complex the collective farm "Peredovoy" — Epidinium, in the JSC "Plemzavod Rodina" — Isotricha and Ophryoscolex. The increase in the average daily milk yield in the experimental groups was from 6.3 to 9.0% in the context of enterprises, an increase in the fat content in milk by 0.05–0.07% and protein by 0.03–0.07% was noted. As a result, in the SKHPK collective farm "Peredovoy" in the experimental group, 283 kg of milk of basic fat content were additionally obtained, and in JSC Plemzavod Rodina — 112 kg. In terms of per day from one head, it is possible to receive additional profit when feeding "Rumit" in the amount of 24.50 rubles. up to 120.15 rubles.
Analysis of parameters characterizing argyrophilic zones in intact lymphocytes of domestic sheep (<i>Ovis aries L.</i>, 1758) and their hybrids with argali (<i>Ovis ammon L.</i>, 1758)
Authors: Klenovitsky P. M. , Iolchiev B. S. , Vetokh A. N. 
Published: March 2021

Relevanceand research material. The study of the characteristics of the nucleolus in cells of various tissues allows us to assess the intensity of the processes of protein proliferation and biosynthesis in animals. In interphase cells, the nucleoli correspond to argyrophilic zones (AgNOR) stained with silver nitric acid. The purpose of this study is to determine the characteristics of AgNOR in sheep interphase lymphocytes of different genotypes based on computer analysis and to select parameters for functional evaluation of nucleoli. AgNOR status was studied in peripheral blood lymphocytes from hybrid sheep four genotypes: purebred Romanov sheep, and their F1 hybrids with argali (groups 1 and 2), hybrids, bearing 3/4 of Romanov sheep blood and 1/4 blood argali (group 3), and hybrids that had 7/8 of domestic sheep and 1/8 blood argali (group 4). The number of argyrophilic zones (AgNOR), their total area (SSNOR), their average color density (DNOR), and the average color density of the core (DN) and its AgNOR-free area (DF) were taken into account.Results. Image processing and analysis were performed using the Image Scope 1.0 program. The average AgNOR value in the studied groups of sheep ranges from 2.64 (group 1) to 3.50 in hybrids in groups 2 and 3. There were no significant differences in the value of SSNOR between the groups. In terms of DN and DF, all hybrids were significantly inferior to purebred sheep (р< 0.001). In terms of DNOR, the sheep of group 2 were significantly inferior to the animals of the other groups (р< 0.001). When evaluating the state of the nucleolus-forming system, it is advisable to take into account the AgNOR number, as well as the average optical densities DN and DF.
Combined tillage with elements of Strip-till technology for maize in the Ciscaucasian zone
Authors: Kuzychenko Yu. A. , Gadzhiumarov R. G. , Dzhandarov A. N. 
Published: March 2021

Relevance. The combined method of the main tillage, using certain methods of influence on the cultivated layer, forms a certain soil density. During the growing season of corn for grain, this indicator changes depending on the seasonal soil moisture and the intensity of the development of the root system of the plant, which is ultimately related to the yield of the crop. Material and method. The objects of research are two systems of basic tillage for corn for grain according to the predecessor winter wheat in the zone of unstable moisture of the Stavropol Territory using a dump and a combined method of basic tillage with elements of Strip-till technology. Soil: southern calcareous chernozem, slightly humus. The functional dependence of soil density on the supply of productive moisture and the intensity of development of the root system of grain corn was established by the method of the theory of dimensions. The method of fractal geometry was used to determine the degree of filling the soil space with root systems of grain corn under various systems of basic tillage.Results and Conclusions. It was found that the density of the soil is in direct functional dependence on the supply of productive moisture in the cultivated soil layer and the intensity of development of plant roots. The soil density during the seeding and flowering periods is higher by the Strip-till technology in comparison with the traditional one on average over the years by 0.02 g / cm3 and 0.03 g / cm3, respectively, and the moisture reserve in the spring period with Strip-till is 12 mm. The intensity of development of the root system according to the indicator D with the Strip-till system (1.58) by 0.31 units, more than with recommended processing (D = 1.27). The yield of corn for grain using the Strip-till technology is on average 0.22 t / g higher than with the recommended one, at a lower cost by 2395 rubles / ha.
The study of the adaptive properties of the initial material of winter bread wheat according to the trait ‘1000-grain weight’
Authors: Kravchenko N. S. , Podgorny S. V. , Vozhzhova N. N. 
Published: March 2021

Introduction. One of the urgent direction in winter wheat breeding is to improve its adaptability, enhance the ability of varieties to give maximum productivity under certain environmental conditions.Methods. The objects of research were 290 samples of winter bread wheat of various ecological and geographical origin taken from the world collection of domestic and foreign selection. In order to estimate the adaptability parameters of the varieties according to the trait ‘1000-grain weight’ there have been selected 31 samples, in accordance with several economically valuable traits. The variety ‘Ermak’ was used as a standard variety.Results. The study has resulted in the identification of the collection samples with different adaptive properties. The samples with bi > 1 ‘Slavna’ (Si2 = 3.01), ‘Chornyava’ (Si2 = 5.64), ‘Etana’ (Si2 = 5.64) can be classified as the varieties of intensive type. The i samples with bi < 1 ‘Ermak’ (bi = 0.93), ‘L 19578’ (bi = 0.42), ‘Simonida’ (bi = 0.21) can be classified as the varieties of extensive type. The samples ‘Vinnichanka’ (bi = -0.07), ‘Zlatka’ (bi = -0.71), ‘Ling Xing 99’ (bi = -0.26) and ‘Sailor’ (bi = -1.22) were identified as adaptable and highly adapted. The samples ‘Vinnichanka’ (Si2 = 0.74), ‘EistanzueLo Benteveo’ (Si2 = 0.82), and ‘Zhong Ping 1597’ (Si2 = 0.23) showed their stability of the trait ‘1000 grain weight’. The samples ‘Zhong Ping 1597’ (Hom = 12119.6), ‘Shestopalivka’ (Hom = 3703.3) and others were characterized by high homeostaticity. The maximum breeding value were identified in the varieties ‘Ling Xing 99’ (Sc = 47.4), ‘Zhong Ping 1597’ (Sc = 46.5), ‘Shestopalivka’ (Sc = 46.3), ‘EistanzueLo Benteveo’ (Sc = 46.3), ‘L 19578’ (Sc = 46.3) and ‘Akter’ (Sc = 45.0). The identified genotypes have been recommended to be used into crossings to develop highly productive varieties adapted to the conditions of the southern part of the Rostov region.