bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter inference with analytical propagators for stochastic models of autoregulated gene expression
Authors: Veerman Frits , Popović Nikola , Marr Carsten 
Published: April 2021

Abstract
Stochastic gene expression in regulatory networks is conventionally modelled via the chemical master equation (CME). As explicit solutions to the CME, in the form of so-called propagators, are oftentimes not readily available, various approximations have been proposed. A recently developed analytical method is based on a separation of time scales that assumes significant differences in the lifetimes of mRNA and protein in the network, allowing for the efficient approximation of propagators from asymptotic expansions for the corresponding generating functions. Here, we showcase the applicability of that method to simulated data from a ‘telegraph’ model for gene expression that is extended with an autoregulatory mechanism. We demonstrate that the resulting approximate propagators can be applied successfully for parameter inference in the non-regulated model; moreover, we show that, in the extended autoregulated model, autoactivation or autorepression may be refuted under certain assumptions on the model parameters. These results indicate that our approach may allow for successful parameter inference and model identification from longitudinal single cell data.
The idiodynamic method: willingness to communicate and anxiety processes interacting in real time
Authors: MacIntyre Peter D. , Gregersen Tammy 
Published: April 2021

AbstractThe idiodynamic method is a relatively new mixed-method approach to studying in real time the complex dynamics of integrated affective and cognitive states that interact continuously with human communication. The method requires video recording a sample of communication from a research participant and then using specialized software to play the video back while collecting contemporaneous self-reported ratings (approximately one per second) on one or more focal variables of interest to the researcher, such as willingness to communicate (WTC) or communication anxiety (CA). After the participant rates the communication sample, a continuous graph of changes in the focal variable is printed. The final step is to interview the speaker to gather an explanation for changes in the ratings, for example at peaks or valleys in the graph. The method can also collect observer ratings that can then be compared with the speaker’s self-ratings. To date, studies have been conducted examining WTC, CA, motivation, perceived competence, teacher self-efficacy, teacher empathy, and strategy use, among other topics. The strengths and limitations of the method will be discussed and a specific example of its use in measuring WTC and CA will be provided.
Argument Mining on Twitter: A survey
Authors: Schaefer Robin , Stede Manfred 
Published: April 2021

Abstract
In the last decade, the field of argument mining has grown notably. However, only relatively few studies have investigated argumentation in social media and specifically on Twitter. Here, we provide the, to our knowledge, first critical in-depth survey of the state of the art in tweet-based argument mining. We discuss approaches to modelling the structure of arguments in the context of tweet corpus annotation, and we review current progress in the task of detecting argument components and their relations in tweets. We also survey the intersection of argument mining and stance detection, before we conclude with an outlook.
Bone density and bone health alteration in boys with Duchenne Muscular Dystrophy: a prospective observational study
Authors: Suthar Renu , Reddy B. V. Chaithanya , Malviya Manisha , Sirari Titiksha , Attri Savita Verma , Patial Ajay , Tageja Minni , Didwal Gunjan , Khandelwal Niranjan K. , Saini Arushi G. , Saini Lokesh , Sahu Jitendra K. , Dayal Devi , Sankhyan Naveen 
Published: April 2021

Abstract

Objectives
Boys with Duchenne Muscular Dystrophy (DMD) are at increased risk for compromised bone health, manifesting as low-impact trauma long bone fractures and vertebral compression fractures.

Methods
In a prospective observational study, we studied bone health parameters in North Indian boys with DMD. We consecutively enrolled ambulatory boys with DMD on glucocorticoid therapy. Bone health was evaluated with X-ray spine, Dual-energy X-ray absorptiometry (DXA), serum calcium, vitamin D3 (25[OH]D), 1,25-dihyroxyvitamin D3 (1,25[OH]2D3), serum osteocalcin, osteopontin, and N terminal telopeptide of type 1 collagen (Ntx) levels.

Results
A total of 76 boys with DMD were enrolled. The median age was 8.5 (interquartile range [IQR] 7.04–10.77) years. Among these, seven (9.2%) boys had long bone fractures, and four (5.3%) had vertebral compression fractures. Fifty-four (71%) boys underwent DXA scan, and among these 31 (57%) had low bone mineral density (BMD, ≤−2 z-score) at the lumbar spine. The mean BMD z-score at the lumbar spine was −2.3 (95% confidence interval [CI] = −1.8, −2.8), and at the femoral neck was −2.5 (95% CI = −2, −2.9). 25(OH)D levels were deficient in 68 (89.5%, n=76) boys, and 1,25(OH)2D3 levels were deficient in all. Mean serum osteocalcin levels were 0.68 ± 0.38 ng/mL (n=54), serum osteopontin levels were 8.6 ± 4.6 pg/mL (n=54) and serum Ntx levels were 891 ± 476 nmol/L (n=54). Boys with low BMD received glucocorticoids for longer duration, in comparison to those with normal BMD (median, IQR [16.9 (6–34) months vs. 7.8 (4.8–13.4) months]; p=0.04).

Conclusions
Bone health is compromised in North Indian boys with DMD. BMD at the lumbar spine is reduced in more than half of boys with DMD and nearly all had vitamin D deficiency on regular vitamin D supplements. Longer duration of glucocorticoid therapy is a risk factor for low BMD in our cohort.
Propofol postpones colorectal cancer development through circ_0026344/miR-645/Akt/mTOR signal pathway
Authors: Cui Xiaomin , Feng Jiying , Wu Jian , Zhang Xiaobao , Ding Mengyao 
Published: April 2021

Abstract
Colorectal cancer (CRC) is responsible for thousands of slow and painful annual deaths. Propofol, an anesthetic, is commonly used in CRC surgery. The role of circularRNA0026344 (circ_0026344) in propofol-treated CRC remains unclear, which was further explored in this study. Real-time polymerase chain reaction (qPCR) was used to detect the expression of circ_0026344 and microRNA645 (miR-645) in CRC cells and normal cells. Western blot was devoted to testing the protein expression of phospho-protein kinase B (p-AKT), AKT, phospho-mammalian target of rapamycin (p-mTOR), and mTOR in CRC cells. Moreover, cell counting kit-8 (CCK8), colony formation, flow cytometry, and transwell assays were employed to assess the proliferation, apoptosis, and metastasis in CRC cells. Circinteractome online tool was applied to predict the combination between circ_0026344 and miR-645, which was further verified by dual-luciferase reporter system. circ_0026344 was lowly expressed and miR-645 was abundantly expressed in CRC cells. The relative protein expression of p-AKT/AKT and p-mTOR/mTOR was strikingly elevated by si-circ#1, which could be reversed by anti-miR-645 in propofol-treated CRC cells. circ_0026344 overexpression inhibited the proliferation and metastasis and promoted apoptosis in CRC cells. Propofol treatment induced the restraint in proliferation and metastasis and stimulation in apoptosis, which were allayed by si-circ#1; meanwhile, this alleviation could further be abolished by anti-miR-645 in CRC cells. Furthermore, circ_0026344 sponged miR-645 to inhibited Akt/mTOR signal pathway in propofol-treated CRC cells. Propofol postponed CRC process by circ_0026344/miR-645/Akt/mTOR axis. This finding might provide a possibility to improve the therapy of CRC with propofol.
COVID-19 severity in relation to sociodemographics and vitamin D use
Authors: Abdulateef Darya Saeed , Rahman Heshu Sulaiman , Salih Jamal Mahmood , Osman Sangar Mahmoud , Mahmood Trifa Abdalla , Omer Shirwan Hama Salih , Ahmed Rana Adnan 
Published: April 2021

Abstract
Most COVID-19 cases are treated as outpatients, while the majority of studies on COVID-19 focus on inpatients. Little is known about the self-reporting and self-rating of the disease’s symptoms, and the associations of prophylactic use of dietary supplements with COVID-19 severity have not been addressed. The aims of this study are to evaluate COVID-19 severity and to relate them to sociodemographic characteristics and prophylactic dietary supplements. An observational patient-based study conducted through an online questionnaire on recovered COVID-19 patients. The patients were assessed for several severity parameters, sociodemographic parameters, and prophylactic dietary supplement use. A total of 428 patients were evaluated. Age and presence of comorbidities had positive associations with the severity parameters. The severe infection group had the highest proportion of patients stressed about COVID-19 (P < 0.05). Cigarette, but not hookah, smoking was significantly associated with less severe symptoms. Vitamin D negatively predicted disease severity (P < 0.05). In conclusion, stress, age, and presence of comorbidities were the most important positive predictors of COVID-19 severity, while prophylactic vitamin D use and smoking were significant negative predictors. The use of protective measures and other prophylactic dietary supplements was not significantly associated with symptom severity.
The crystal structure of 6,6′-((1E,1′E)-hydrazine-1,2-diylidenebis(methaneylylidene)) bis(2-bromo-4-nitrophenol) — dimethylsulfoxide (1/2), C14H8Br2N4O6⋅2(C2H6OS)
Authors: Ma Ling , Yang Ruoqi , Li Jianqing 
Published: April 2021

Abstract
C14H8Br2N4O6⋅2(C2H6OS), triclinic,

P

1
‾

$P\bar{1}$

(no. 2), a = 6.1463(12) Å, b = 8.3637(16) Å, c = 12.461(3) Å, α = 85.578(5)°, β = 85.942(5)°, γ = 86.310(5)°, V = 635.9(2) Å3, Z = 1, R

gt
(F) = 0.0601, wR

ref
(F
2) = 0.0983, T = 296 K.

CCDC no.: 2057510
The crystal structure of methyl 4-(1H-naphtho[1,8-de][1,3,2]diazaborinin-2(3H)-yl)benzoate, C18H15BN2O2
Authors: Ren Huaping , Miao Zong-Cheng 
Published: April 2021

Abstract
C18H15BN2O2, monoclinic, P21/c (no. 14), a = 6.8522(9) Å, b = 8.4333(11) Å, c = 13.1908(18) Å, β = 95.880(5)°, V = 758.24(17) Å3, Z = 2, R

gt
(F) = 0.0381, wR

ref
(F
2) = 0.1068, T = 193 K.

CCDC no.: 2045109
Crystal structure of N′, N‴-((propane-2,2-diylbis(1H-pyrrole-5,2-diyl))bis (methaneylylidene))di(picolinohydrazide) – water – methanol (1/1/1), C25H24N8O2·H2O·CH3OH
Authors: Xiong Ying , An Ya 
Published: April 2021

Abstract
C26H30N8O4, triclinic,

P

1
‾

$P&#x203e;{1}$

(no. 2), a = 8.0277(6) Å, b = 11.1460(10) Å, c = 15.8921(13) Å, α = 99.439(3)°, β = 102.525(3)°, γ = 95.309(3)°, V = 1357.17(19) Å3, Z = 2, R
gt(F) = 0.0442, wR
ref(F
2) = 0.1167, T = 273 K.
Nanostructured multifunctional electrocatalysts for efficient energy conversion systems: Recent perspectives
Authors: Rahman Sheikh Tareq , Rhee Kyong Yop , Park Soo-Jin 
Published: April 2021

Abstract
Electrocatalysts play a significant performance in renewable energy conversion, supporting several sustainable methods for future technologies. Because of the successful fabrication of distinctive oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) electrocatalysts, bifunctional ORR/OER and HER/OER electrocatalysts have become a hot area of contemporary research. ORR, OER, and HER have gained considerable attention because of their strong performance in different energy conversion and storage devices, including water-splitting devices, fuel cells, and metal–air rechargeable batteries. Therefore, the development of effective nanostructured multifunctional electrocatalysts for ORR, OER, and HER is necessary; and there is a demand for their industrialization for sustainable energy technology. In this review, details of current improvements in multifunctional catalysts for ORR/OER as well as HER/OER are presented, focusing on insight into the theoretical considerations of these reactions through investigation and estimation of different multifunctional catalysts. By analyzing the universal principles for various electrochemical reactions, we report a systematic scheme to clarify the recent trends in catalyzing these reactions over various types of nanostructure catalysts. The relevant reaction pathways and the related activity details for these reactions in the current literature are also included. Overall, the current demands and future outlines for improving the prospects of multifunctional electrocatalysts are discussed.
Effect of MnO
x
modification and template type on the catalytic performance of ceria-zirconia in CO and soot oxidation
Authors: Kaplin Igor Yu. , Lokteva Ekaterina S. , Bataeva Svetlana V. , Maslakov Konstantin I. , Fionov Alexander V. , Shumyantsev Alexey V. , Isaikina Oksana Ya. , Kamaev Alexey O. , Golubina Elena V. 
Published: April 2021

Abstract
The effect of the template nature and modification with MnO
x
on the catalytic efficiency of Ce0.8Zr0.2O2 (CZ) in oxidation of CO (2 vol% CO and 1 vol% O2 in He, pulse feeding) and soot particles (tight contact between soot and catalyst, TGA/DSC) was analyzed. The CZ catalysts were prepared using the CTAB and sawdust (SD) templates and modified with Mn (8 wt%) by wet impregnation followed by calcination at 400 °С. SEM-EDS, XRD, Raman and photoelectron spectroscopy, N2 adsorption, EPR, TPR-H2 and catalytic tests results demonstrated better catalytic activity of CZ(SD) in CO oxidation than of CZ(CTAB) because of the biomorphic texture, higher structural defectiveness and improved oxygen mobility of the former catalyst. Low surface reducibility and low concentration of active oxygen species on the CZ(SD) surface deteriorated its catalytic efficiency in the topochemical reaction of soot oxidation. Despite the different structure and degree of interaction between MnO
x
and CZ, the Mn-modified catalysts showed the similar catalytic properties: much better than of both unmodified catalysts in CO oxidation and worse than of CZ(CTAB) in soot oxidation. Mn2+ ions incorporated better into the surface layer of CZ(SD) than of CZ(CTAB), for which the inhomogeneous distribution of MnO
x
and decreased specific surface area were observed.
The Pursuit of Parmenidean Clarity
Authors: Bryan Jenny 
Published: April 2021

AbstractThis paper reconsiders the debates around the interpretation of Parmenides’ Being, in order to draw out the preconceptions that lie behind such debates and to scrutinize the legitimacy of applying them to a text such as Parmenides’ poem. With a focus on the assumptions that have driven scholars to seek clarity within the notoriously ambiguous verse of the poem, I ask whether it is possible to develop an analysis of Parmenides’ Being that is sympathetic both to his clear interest in argument, logic, knowledge and truth and to his ambiguous expression and cultural and literary resonances.
Sleep disturbance in patients attending specialized chronic pain clinics in Denmark: a longitudinal study examining the relationship between sleep and pain outcomes
Authors: Vaegter Henrik Bjarke , Høybye Mette Terp , Bergen Frederik Hjorth , Parsons Christine E. 
Published: April 2021

Abstract

Objectives
Sleep disturbances are highly prevalent in patients with chronic pain. However, the majority of studies to date examining sleep disturbances in patients with chronic pain have been population-based cross-sectional studies. The aims of this study were to 1) examine the frequency of sleep disturbances in patients referred to two interdisciplinary chronic pain clinics in Denmark, 2) explore associations between sleep disturbances and pain intensity, disability and quality of life at baseline and follow-up, and 3) explore whether changes in sleep quality mediated the relationships between pain outcomes at baseline and pain outcomes at follow-up.

Methods
We carried out a longitudinal observational study, examining patients enrolled in two chronic pain clinics assessed at baseline (n=2,531) and post-treatment follow-up (n=657). Patients reported on their sleep disturbances using the sleep quality subscale of the Karolinska Sleep Questionnaire (KSQ), their pain intensity using 0–10 numerical rating scales, their pain-related disability using the Pain Disability Index (PDI), and quality of life using the EuroQol-VAS scale. The average time between baseline and follow-up was 207 days (SD=154).

Results
At baseline, the majority of patients reported frequent sleep disturbances. We found a significant association at baseline between self-reported sleep disturbances and pain intensity, pain-related disability, and quality of life, where greater sleep disturbance was associated with poorer outcomes. At follow-up, patients reported significant improvements across all pain and sleep outcomes. In two mediation models, we showed that changes in sleep disturbances from baseline to follow-up were significantly associated with (i) pain intensity at follow-up, and (ii) pain disability at follow-up. However, baseline pain intensity and disability scores were not associated with changes in sleep disturbances and, we did not find evidence for significant mediation of either pain outcome by changes in sleep disturbances.

Conclusions
Self-reported sleep disturbances were associated with pain outcomes at baseline and follow-up, with greater sleep disturbances associated with poorer pain outcomes. Changes in sleep quality did not mediate the relationships between baseline and follow-up scores for pain intensity and disability. These findings contribute to a growing body of evidence confirming an association between sleep and chronic pain experience, particularly suggestive of a sleep to pain link. Our data following patients after interdisciplinary treatment suggests that improved sleep is a marker for a better outcome after treatment.
Research on quasi-one-dimensional modeling and performance analysis of RBCC propulsion system
Authors: Zhang Dong , Cheng Feng , Tang Shuo , Gong Chun-lin , Xu Bin 
Published: April 2021

Abstract
Quasi-one-dimensional model is the most effective way to realize the rapid iterative design of the overall scheme and control system of RBCC aircraft and has become a research hotspot. In the current research, the quasi-one-dimensional model of RBCC propulsion system is simplified. The model does not include physical characteristics such as wall heat transfer, boundary layer change, specific heat ratio change and transonic flow singularity, which makes the accuracy of the model low and cannot adapt to flight control in large airspace. A RBCC model with high accuracy and adaptability to wide-speed fly is established in this paper. Firstly, based on the laws of kinetic energy conservation and energy conservation, the thrust model of ejection mode is established. Secondly, the quasi-one-dimensional flow control equation is deduced, and the physical mechanism models of core flow area, transonic flow, pre-combustion shock train, heat release law and mixing efficiency are established. On this basis, the quasi-one-dimensional flow model of RBCC dual-mode ramjet is established. Thirdly, based on the law of momentum conservation, the mathematical model of rocket mode is deduced, and the thrust model of rocket mode is established. Finally, the accuracy of the quasi-one-dimensional model is verified by CFD numerical simulation and direct-connect experiment. Taking a typical RBCC launch vehicle as an example, the wide-speed performance of the RBCC propulsion system is calculated and analyzed.
Exergy Analysis of a Turboprop Engine at Different Flight Altitude and Speeds Using Novel Consideration
Authors: Dinc Ali , Gharbia Yousef 
Published: April 2021

Abstract
In this study, exergy efficiency calculations of a turboprop engine were performed together with main performance parameters such as shaft power, specific fuel consumption, fuel flow, thermal efficiency etc., for a range of flight altitude (0–14 km) and flight speeds (0–0.6 Mach). A novel exergy efficiency formula was derived in terms of specific fuel consumption and it is shown that these two parameters are inversely proportional to each other. Moreover, a novel exergy efficiency and thermal efficiency relation was also derived. The relationship showed that these two parameters are linearly proportional to each other. Exergy efficiency of the turboprop engine was found to be in the range of 23–33%. Thermal efficiency of the turboprop engine was found to be around 25–35%. Exergy efficiency is higher at higher speeds and altitude where the specific fuel consumption is lower. Conversely, exergy efficiency of the engine is lower for lower speeds and altitude where the specific fuel consumption is higher.
Study on inversion control for integrated helicopter/engine system with variable rotor speed based on state variable model
Authors: Wang Yong , Zheng Qiangang , Zhang Haibo , Chen Haoying 
Published: April 2021

AbstractIn order to realize the fast response control for turboshaft engine with variable rotor speed, a dynamic inversion (DI) control method based on state variable model of turboshaft engine is proposed. Meanwhile, in order to expand the application of dynamic inversion controller, the linear parameter varying (LPV) model of turboshaft engine is applied, which constitutes the LPV/DI controller together. The simulation results shows that compared with the conventional PID controller, the LPV/DI controller can effectively reduce the overshoot/droop of the power turbine speed to less than 1% under different flight conditions. The control effect is remarkable and the robust performance is superior.
Experimental research on the performance of the forward variable area bypass injector for variable cycle engines
Authors: Zhang Binglong , Liu He , Zhou Jianhua , Liu Hui 
Published: April 2021

Abstract
The forward variable area bypass injector (FVABI) is a key component of double bypass variable cycle engine (VCE) to achieve mode transition and bypass ratio adjustment. In this paper, an experimental system for FVABI was constructed based on the analysis of relevant experimental theories, and then the experiments on FVABI were carried out for a specific working state in double bypass mode of VCE and for the comparison working states with different area ratios and different back pressure ratios. The results showed that the FVABI designed in this paper meets the requirements of VCE at this working state. The analysis of the influence of area ratio and back pressure ratio on the injection coefficient showed that the first bypass valve and back pressure were effective means to control the mass flow of FVABI.
An active fault-tolerant control strategy of aircraft engines based on multi-model predictive control
Authors: Du Xian , Ma Yan-Hua 
Published: April 2021

Abstract
In order to mitigate or even eliminate the adverse effects caused by typical components faults of aircraft engines, an active fault-tolerant strategy based on multi-model predictive control is proposed, which consists of a pre-established multi-model library, a judgement module, and corresponding predictive controllers with smooth transition switching logic. Multiple dynamic nonlinear or linear models are firstly established by means of system identification methods, based on the component-level nonlinear engine model or historical data in faults cases. The judgement module is utilized to online compare the engine measured outputs with that of all models in the pattern library and select the best matched dynamic model on the basis of outputs error quadratic performance index, thus determining the most appropriate predictive controller for the next control sample period. When a certain fault occurs, the fault model in the library could be identified and fault-model based predictive controller is activated. Finally, two kinds of pre-considered high-pressure compressor and high-pressure turbine component-level faults are taken as an example to design the active fault-tolerant controller. Simulation results show that the judgement module owns the ability to sense the fault and gives smooth switching signal to the suitable predictive controller, verifying the effectiveness of the proposed technique.