bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Urgenda: The role of the ECHR and judgments of the ECtHR in Dutch environmental and climate litigation
Authors: Krommendijk Jasper 
Published: July 2021

AbstractHuman rights have been championed as the new frontier in environmental and climate change litigation, especially since the Dutch Urgenda case. However, little is known about whether this alleged turn to rights is really happening beyond a few high‐profile judgments. This article examines how and when courts have relied on the European Convention on Human Rights (ECHR) and case law of the European Court of Human Rights (ECtHR) in environmental cases in the Netherlands since 2016. In doing so, it will show the broad potential and wide range of environmental cases in which rights are used. Rights talk is at the same time frequently overlooked or avoided by the parties and the courts, partly because the added value is limited in the light of specific national (EU‐inspired) statutory provisions. To date, the actual impact of the EC(t)HR has been rather minimal beyond Urgenda, partly because of the limitations in the ECHR. This articles sketches avenues for further (empirical) research.
Clinical presentation, treatment and outcome in dogs with pemphigus foliaceus with and without vasculopathic lesions: an evaluation of 41 cases
Authors: Zhou Zijin , Corner Sarah , Petersen Annette , Rosser Edmund , Noland Erica L 
Published: June 2021

BackgroundConcurrent vasculopathic lesions in dogs with pemphigus foliaceus (PF) have been observed anecdotally yet not reported in the literature. Any association with prognosis is unclear.Hypothesis/ObjectivesTo compare clinical features and outcome of PF in dogs with and without vasculopathic lesions.AnimalsArchived, formalin‐fixed, paraffin‐embedded biopsy samples of 41 dogs with PF.Methods and materialsArchived, formalin‐fixed, paraffin‐embedded biopsy samples with a histological diagnosis of PF were selected and re‐evaluated independently. Dogs were assigned to groups following histological evaluation: Group 1 (no vasculopathic lesions) and Group 2 (vasculopathic lesions present). Group 2 was subdivided into Group 2a (vasculopathic lesions without vasculitis – i.e. vasculopathy) and Group 2b (overt vasculitis). Medical records from identified cases were reviewed retrospectively for data on clinical presentation, treatment and outcome.ResultsTime to remission was longer in Group 2b (93.8 days) compared to Group 1 (41.8 days) (P = 0.047). Dogs in groups 2a and 2b were more likely to have systemic signs of illness at presentation (P = 0.028 and P = 0.032, respectively) compared to Group 1. Dogs in Group 2b were more likely to have adverse effects associated with treatment than dogs in Group 1 (P = 0.004). There were no significant differences in lesion type, distribution, rates of remission, recurrence or corticosteroid dosage between groups.Conclusions and clinical importanceDogs with PF and concurrent vasculitis took longer to achieve remission and were more likely to have systemic signs of illness or adverse effects associated with treatment than dogs with PF without concurrent vasculopathic lesions.
Shakedown and Limit Analysis of Kinematic Hardening Piping Elbows Under Internal Pressure and Bending Moments
Authors: Peng Heng , Liu Yinghua 
Published: June 2021

Abstract
In this paper, the stress compensation method (SCM) adopting an elastic-perfectly plastic (EPP) material is further extended to account for limited kinematic hardening (KH) material model based on the extended Melan's static shakedown theorem using a two-surface model defined by two hardening parameters, namely, the initial yield strength and the ultimate yield strength. Numerical analysis of a cylindrical pipe is performed to validate the outcomes of the extended SCM. The results agree well with ones from literature. Then the extended SCM is applied to the shakedown and limit analysis of KH piping elbows subjected to internal pressure and cyclic bending moments. Various loading combinations are investigated to generate the shakedown limit and the plastic limit load interaction curves. The effects of material hardening, elbow angle, and loading conditions on the shakedown limit and the plastic limit load interaction curves are presented and analyzed. The present method is incorporated in a commercial finite element simulation software and can be considered as a general computational tool for shakedown analysis of KH engineering structures. The obtained results provide a useful information for the structural design and integrity assessment of piping elbows.
Effect of the Heat Transfer Coefficient Reference Temperatures on Validating Numerical Models of Supercritical CO2
Authors: Chao Yang , Lopes Nicholas C. , Ricklick Mark A. , Boetcher Sandra K. S. 
Published: June 2021

Abstract
Validating turbulence models for cooling supercritical carbon dioxide (sCO2) in a horizontal pipe is challenging due to the lack of experimental data with spatially resolved local temperature measurements. Although many variables may be present to cause discrepancies between numerical and experimental data, this study focuses on how the choice of reference temperatures (both wall reference temperature and fluid bulk reference temperature) when calculating the heat transfer coefficient influences turbulence-model validation results. While it may seem straightforward to simply use the same parameters as the experimental setup, this has not been observed in practice. In this work, numerical simulations are performed for cooling sCO2 in a horizontal pipe for p = 8 MPa, d = 6 mm, G = 200, and 400 kg/(m2s), and qw = 12, 24, and 33 kW/m2. Local and average heat transfer coefficients with different reference temperatures, found to be frequently used in the literature, are presented and compared with commonly used experimental data. It was found that the choice of reference temperatures has a significant influence on the results of the numerical validation. Historically, the higher heat flux cases have been more difficult to validate, theorized due to using reference temperatures differing from the experiment; however, good agreement was found here using the reference temperatures that most closely matched the experiment. This not only highlights the need for careful selection of reference temperatures in simulations, but also the importance of clearly defining the reference temperature employed when reporting experimental results.
Dearborn SHINES During the COVID-19 Pandemic: Youth Experiences and Outcomes With Virtual Physical Activity and Healthy Eating Programming
Authors: Barcelona Jeanne , Centeio Erin , Arvidson Paige , Hijazi Kowsar 
Published: June 2021

Purpose: This exploratory study evaluated how youth healthy eating (HE) and physical activity (PA) behaviors could be influenced by a whole-of-school program, which was transformed to a virtual setting at the onset of the COVID-19 pandemic. The authors investigated how students experienced programming and the role of students’ perceptions of parental support in their self-reported engagement in HE and PA.Methods: PA and HE curricula were provided across 15 schools over 12 weeks. Students (N = 879,Mage = 12.12 years, 63% female) completed a survey evaluating the value and perceptions around programmatic aspects as well as their self-reported engagement in HE and PA.Results: Multiple regression analyses revealed positive relationships between parental support for PA and student engagement, as well as positive relationships between students’ self-efficacy and HE behaviors.Conclusion: Findings indicate that students utilized virtual HE and PA programming and that parent support helped to facilitate engagement in PA and HE behaviors beyond the school setting.
Effectiveness and safety of reactive focal mass drug administration (rfMDA) using dihydroartemisinin–piperaquine to reduce malaria transmission in the very low-endemic setting of Eswatini: a pragmatic cluster randomised controlled trial
Authors: Vilakati Sibonakaliso , Mngadi Nontokozo , Benjamin-Chung Jade , Dlamini Nomcebo , Dufour Mi-Suk Kang , Whittemore Brooke , Bhangu Khayelihle , Prach Lisa M , Baltzell Kimberly , Nhlabathi Nomcebo , Malambe Calisile , Dlamini Bongani , Helb Danica , Greenhouse Bryan , Maphalala Gugu , Pindolia Deepa , Kalungero Muhindo , Tesfa Getahun , Gosling Roly , Ntshalintshali Nyasatu , Kunene Simon , Hsiang Michelle S 
Published: June 2021

IntroductionTo reduce malaria transmission in very low-endemic settings, screening and treatment near index cases (reactive case detection (RACD)), is widely practised, but the rapid diagnostic tests (RDTs) used miss low-density infections. Reactive focal mass drug administration (rfMDA) may be safe and more effective.MethodsWe conducted a pragmatic cluster randomised controlled trial in Eswatini, a very low-endemic setting. 77 clusters were randomised to rfMDA using dihydroartemisin–piperaquine (DP) or RACD involving RDTs and artemether–lumefantrine. Interventions were delivered by the local programme. An intention-to-treat analysis was used to compare cluster-level cumulative confirmed malaria incidence among clusters with cases. Secondary outcomes included safety and adherence.ResultsFrom September 2015 to August 2017, 222 index cases from 47 clusters triggered 46 RACD events and 64 rfMDA events. RACD and rfMDA were delivered to 1455 and 1776 individuals, respectively. Index case coverage was 69.5% and 62.4% for RACD and rfMDA, respectively. Adherence to DP was 98.7%. No serious adverse events occurred. For rfMDA versus RACD, cumulative incidences (per 1000 person-years) of all malaria were 2.11 (95% CI 1.73 to 2.59) and 1.97 (95% CI 1.57 to 2.47), respectively; and of locally acquired malaria, they were 1.29 (95% CI 1.00 to 1.67) and 0.97 (95% CI 0.71 to 1.34), respectively. Adjusting for imbalance in baseline incidence, incidence rate ratio for rfMDA versus RACD was 0.93 (95% CI 0.54 to 1.62) for all malaria and 0.84 (95% CI 0.42 to 1.66) for locally acquired malaria. Similar results were obtained in a per-protocol analysis that excluded clusters with <80% index case coverage.ConclusionIn a very low-endemic, real-world setting, rfMDA using DP was safe, but did not lower incidence compared with RACD, potentially due to insufficient coverage and/or power. To assess impact of interventions in very low-endemic settings, improved coverage, complementary interventions and adaptive ring trial designs may be needed.Trial registration numberNCT02315690.
COVID-19 distribution in Bogotá, Colombia: effect of poverty during the first 2 months of pandemic
Authors: Moreno-Montoya Jose , Ballesteros Silvia Marcela , Idrovo Alvaro Javier 
Published: June 2021

BackgroundThe current SARS-CoV-2 pandemic has especially affected individuals living in conglomerate settings having poverty as common characteristic. However, evidence of the association between COVID-19 severity and social determinants is still scarce, particularly, for Latin American countries. The objective was to assess the effect of socioeconomic deprivation in the clinical severity of COVID-19 infection among different localities of Bogotá, Colombia.MethodsSecondary analyses using data of SARS-CoV-2 infected cases in Bogotá from 6 March 2020 to 19 April 2020 were carried out. Direct and indirect indicators of deprivation at area level and individual demographic characteristics (age, sex and type of case) were included in the analyses.Findings1684 COVID-19 cases were included in the study. There were 217 (12.9%; 95% CI 11.3 to 14.5) serious cases, of which 32.6% (95% CI 26.4 to 38.8) cases were deceased. In the multilevel logistic regression, age, sex (female), type of case (different of imported case), number of serious cases recorded the previous day and multidimensional poverty were associated with serious cases (median OR: 1.72, 95% CI 1.56 to 1.87).InterpretationThis paper explored the association between COVID-19 severity and social determinants. Expressions of poverty were associated with more severe cases during first 2 months of pandemic. It is a clear syndemic for the joint presentation of COVID-19 and other comorbidities among more serious cases.
Characteristics of those most vulnerable to employment changes during the COVID-19 pandemic: a nationally representative cross-sectional study in Wales
Authors: Gray Benjamin J , Kyle Richard G , Song Jiao , Davies Alisha R 
Published: June 2021

BackgroundThe public health response to the SARS-CoV-2 (COVID-19) pandemic has had a detrimental impact on employment and there are concerns the impact may be greatest among the most vulnerable. We examined the characteristics of those who experienced changes in employment status during the early months of the pandemic.MethodsData were collected from a cross-sectional, nationally representative household survey of the working age population (18–64 years) in Wales in May/June 2020 (n=1379). We looked at changes in employment and being placed on furlough since February 2020 across demographics, contract type, job skill level, health status and household factors. χ2or Fisher’s exact test and multinomial logistic regression models examined associations between demographics, subgroups and employment outcomes.ResultsOf our respondents, 91.0% remained in the same job in May/June 2020 as they were in February 2020, 5.7% were now in a new job and 3.3% experienced unemployment. In addition, 24% of our respondents reported being placed on furlough. Non-permanent contract types, individuals who reported low mental well-being and household financial difficulties were all significant factors in experiencing unemployment. Being placed on ‘furlough’ was more likely in younger (18–29 years) and older (60–64 years) workers, those in lower skilled jobs and from households with less financial security.ConclusionA number of vulnerable population groups were observed to experience detrimental employment outcomes during the initial stage of the COVID-19 pandemic. Targeted support is needed to mitigate against both the direct impacts on employment, and indirect impacts on financial insecurity and health.
Prevalence of hepatitis B immunity and infection in home self-sampling HIV service users
Authors: Roche Rachel , Simmons Ruth , Logan Louise , Ledesma Juan , Sabin Caroline , Ijaz Samreen , Mandal Sema 
Published: June 2021

ObjectivesAlthough hepatitis B virus (HBV) vaccination for high-risk groups including gay, bisexual and other men who have sex with men (MSM) is recommended in the UK, data on HBV immunisation coverage are limited. This study aimed to understand the prevalence of HBV infection, susceptibility and immunity due to immunisation among a high-risk population of MSM and heterosexuals who are less likely to attend sexual health services.MethodsResidual HIV-negative serology samples archived from a national HIV self-sampling service in 2016 were tested for HBV markers using an unlinked anonymous approach. Prevalence of HBV infection, evidence of immunisation and susceptibility were calculated and stratified by individuals’ characteristics. Multinomial logistic regression was used to estimate relative risk ratios (RRRs) associated with covariates.ResultsOf 2172 samples tested, 1497 (68.9%) were from MSM and 657 (30.2%) were from heterosexuals. Susceptibility to HBV infection was 66.1% among MSM and 77.0% among heterosexuals. Only 29.9% of MSM and 17.4% of heterosexuals had serological evidence of immunisation. Current infection was 1.1% in heterosexuals and 0.2% in MSM. Adjusted analysis showed evidence of immunisation was lower among heterosexuals (RRR 0.66, 95% CI 0.50 to 0.86) and those with no previous HIV test (RRR 0.41, 95% CI 0.31 to 0.54), and higher in those of other white or other ethnicity.ConclusionsAmong MSM and heterosexual users of a self-sampling HIV service, evidence of immunisation to HBV infection was low and susceptibility to infection was comparatively high, suggesting suboptimal delivery of HBV immunisation in sexual health services.
California’s tobacco 21 minimum sales age law and adolescents’ tobacco and nicotine use: differential associations among racial and ethnic groups
Authors: Grube Joel W , Lipperman-Kreda Sharon , García-Ramírez Grisel , Paschall Mallie J , Abadi Melissa H 
Published: June 2021

ObjectiveA California, USA, law raised the minimum tobacco sales age to 21 (T21) on 9 June 2016. We investigated whether T21 was associated with reductions adolescents’ use of tobacco cigarettes, smokeless tobacco and electronic cigarettes and whether these associations differed across racial and ethnic groups.MethodsSecondary analyses of data from 2 956 054 7th, 9th and 11th grade students who participated in the California Healthy Kids Survey from 2010–11 to 2017–2018.ResultsMultilevel mixed effects logistic regression analyses showed that T21 was associated with reduced prevalence of lifetime smokeless tobacco and e-cigarette use and past month smokeless tobacco use in the overall student population. T21 was associated with increases in prevalence of past month e-cigarette use. Moderation analyses indicated differences by racial and ethnic groups. Notably, T21 was associated with reductions in lifetime and past 30-day use of all tobacco and nicotine products among Latinx youth. The findings were more mixed for other racial and ethnic groups. Slopes analyses indicated that T21 was associated with accelerated downward trends for 30-day cigarette and smokeless use; moderated trends for lifetime cigarette smoking such that downward slopes became less steep; and reversed downward trends for e-cigarette use. Changes in slopes varied across racial and ethnic groups.ConclusionsOur findings highlight the importance of understanding the complex associations that T21 and other tobacco control policies have with the use of different tobacco and nicotine products among racial and ethnic groups. Future research should investigate mechanisms underlying these differences to inform tobacco control efforts.
Flavour chemicals, synthetic coolants and pulegone in popular mint-flavoured and menthol-flavoured e-cigarettes
Authors: Omaiye Esther E , Luo Wentai , McWhirter Kevin J , Pankow James F , Talbot Prue 
Published: June 2021

BackgroundThe Food and Drug Administration (FDA) has recently banned flavours from pod-style electronic cigarettes (e-cigarettes), except for menthol and tobacco. JUUL customers have quickly discovered that flavoured disposable e-cigarettes from other manufacturers, such as Puff, are readily available. Our goal was to compare flavour chemicals, synthetic coolants and pulegone in mint-flavoured/menthol-flavoured e-cigarettes from JUUL and Puff, evaluate the cytotoxicity of the coolants and perform a cancer risk assessment for pulegone, which is present in both JUUL pods and disposable Puff products.MethodsIdentification and quantification of chemicals were performed using gas chromatography/mass spectrometry. Cytotoxicity of the coolants was evaluated with BEAS-2B cells using the MTT 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyltetrazolium bromide assay. The cancer risk of pulegone was calculated using the margin of exposure (MOE).ResultsMenthol was the dominant flavour chemical (>1 mg/mL) in all products from both manufacturers. Minor flavour chemicals (<1 mg/mL) differed in the JUUL and Puff fluids and may produce flavour accents. The concentrations of WS-3 and WS-23 were higher in Puff than in JUUL. WS-23 was cytotoxic in the MTT assay at concentrations 90 times lower than concentrations in Puff fluids. The risk of cancer (MOE<10 000) was greater for mint than for menthol products and greater for Puff than for JUUL.ConclusionsSwitching from flavoured JUUL to Puff e-cigarettes may expose users to increased harm due to the higher levels of WS-23 and pulegone in Puff products. Cancer risk may be reduced in e-cigarettes by using pure menthol rather than mint oils to produce minty-flavoured e-cigarette products.
Own-price and cross-price elasticities of demand for cigarettes and waterpipe tobacco in three Eastern Mediterranean countries: a volumetric choice experiment
Authors: Chalak Ali , Nakkash Rima , Abu-Rmeileh Niveen M E , Khader Yousef S , Jawad Mohammed , Mostafa Aya , Abla Ruba , Louviere Jordan , Salloum Ramzi G 
Published: June 2021

BackgroundWaterpipe tobacco smoking rates in the Eastern Mediterranean region are among the highest worldwide, yet little evidence exists on its economics. Estimates of demand elasticities for tobacco products are largely limited to cigarettes. This study aimed to estimate own-price and cross-price elasticities of demand for cigarettes and waterpipe tobacco products in Lebanon, Jordan and Palestine.MethodsA volumetric choice experiment was conducted using nationally representative household surveys. The choice experiment elicited respondents’ stated purchases of eight cigarette and waterpipe tobacco product varieties by hypothetically varying prices. Data were analysed using zero-inflated Poisson models that yielded demand elasticity estimates of cigarette and waterpipe tobacco consumption.ResultsThe study included 1680 participants in Lebanon (50% female), 1925 in Jordan (44.6% female) and 1679 in Palestine (50% female). We found the demand for premium cigarettes to be price elastic (range, −1.0 to −1.2) across all three countries, whereas the demand for discount cigarettes was less elastic than premium cigarettes in Lebanon (−0.6) and Jordan (−0.7) and more elastic in Palestine (−1.2). The demand for premium waterpipe tobacco was highly elastic in Lebanon (−1.9), moderately elastic in Jordan (−0.6) and inelastic in Palestine (0.2). The cross-price elasticity between cigarettes and waterpipe tobacco was near zero, suggesting that the two products are not considered to be close substitutes by consumers.ConclusionsThese results serve as a strong evidence base for developing and implementing fiscal policies for tobacco control in the Eastern Mediterranean region that address cigarettes and waterpipe tobacco products.
Fine-scale behavior of red snapper (Lutjanus campechanus) around bait: approach distances, bait plume dynamics, and effective fishing area
Authors: Bacheler Nathan M. , Runde Brendan J. , Shertzer Kyle W. , Buckel Jeffrey A. , Rudershausen Paul J. 
Published: July 2021

The behavior of fish around bait is poorly understood despite it being important for the fish catching process and estimating relative abundance. We used a fine-scale acoustic positioning system to quantify the movements of 26 red snapper (Lutjanus campechanus) around 120 bait deployments in 2019 at a natural reef site (∼37-m deep) in North Carolina, USA. There were 39 instances of tagged red snapper approaching bait during four baiting days, some of which approached due to apparent sensory cues (28%), while most approached incidentally (72%). Tagged red snapper approached bait from initial distances of 1 to 1147 m (median = 27 m; mean = 86 m), and took 0–77 min (mean = 22 min) to approach. Fish were more likely to approach bait if they were located close to, and down-current of, the bait at deployment. Our estimated effective fishing area of 2290 m2 (within which >50% of red snapper responded to bait) could be used along with video counts and other information to estimate densities of red snapper.