bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood Social Cohesion is Associated with Food Security Status in Households with and without Children in the U.S.
Authors: Martini Lauren , Burke Michael , Younginer Nicholas 
Published: June 2021

Neighborhood social cohesion is thought to alleviate food insecurity, but the association is not well understood.Using a 2013 national sample, we tested the association between neighborhood social cohesion and household food security. Four items measured social cohesion (i.e., can count on neighbors, neighbors who help each other, closely knit neighbors, trustworthy neighbors) and food security was measured by the 10‐item USDA Household Food Security Survey. The social cohesion items were summed and treated as continuous. Multinomial logistic regression assessed the association between social cohesion and food security (i.e., food secure (reference), low food secure (LFS), and very low food secure (VLFS)). Models were stratified by households with (n=6,375) or without (n=13,937) children and adjusted for demographic and socioeconomic confounders.In households with children, social cohesion score was associated with decreased odds of LFS (odds ratio (OR) 0.95; 95% confidence Interval (CI) 0.93‐0.96) and VLFS (OR 0.90; 95% CI 0.88‐0.91). In households without children, social cohesion score was associated with decreased odds of LFS (OR 0.96, 95% CI 0.93‐0.99) and VLFS (OR 0.89; 95% CI 0.85‐0.92).Higher neighborhood social cohesion is associated with higher food security among households with and without children in the U.S.The University of South Carolina supported this work.
Cost and Availability of Gluten‐Free Food Products in Northwestern México
Authors: Arias‐Gastélum Mayra , Cabrera‐Chávez Francisco , Delgado‐Uriarte Marianela , Vergara‐Jiménez Marcela , Magaña‐Gómez Javier , Magaña‐Ordorica Dalia , Ontiveros Noe 
Published: June 2021

ObjectiveTo evaluate the availability and cost of gluten‐free food products (GFP) in Northwestern México.MethodsA Mexican market basket of wheat‐containing products was created based on data from the National Council for the Evaluation of Social Development Policy (CONEVAL). The cost and availability of GFP and their wheat counterparts were recorded in 2 border and 3 non‐border cities from Northwestern México. A total of 26 supermarkets and health food stores were included. Products were grouped into 17 food categories. Availability of GFP was defined as the proportion of categories found in each city. Cost was calculated per 100 grams or 10 mL of product. Mann‐Whitney T test was used for statistical comparisons.ResultsA total of 101 GFP were found among all stores. Product availability ranged from 47% to 100% among the cities. The most common products were cereal bars (n=19) and pastas (n=14) in non‐border cities, and in border cities (cereal bars n= 10, pastas n= 11). The availability of GFP per store fluctuates between 6‐59% among 8 health‐food stores and between 0‐47% in 5 out of 6 supermarkets. One supermarket had 88% of availability. Overall, GFP were more expensive than their wheat‐based counterparts (P < .05) and pasta products had the highest price difference (up to ten fold).ConclusionIn Northwestern Mexico, there is low availability of GFP, and these are more expensive than their wheat‐based counterparts. This represents a challenge for individuals in need to follow a gluten free diet. Supported by PROFAPI 2013/009.
Overweight and Obesity in School Age Population Beneficiaries of School Breakfasts Program in San Luis Potosí, Mexico
Authors: Morales‐Ruan Ma. del Carmen , Mendez Gomez‐Humaran Ignacio , Cuevas‐Nasu Lucia , Shamah‐Levy Teresa 
Published: June 2021

ObjectiveTo establish the association between overweight and obesity and to be beneficiary of the School Breakfasts Program (PDE) in school age children from San Luis Potosí, Mexico.Materials and methods: information from 403 children was analyzed, 303 belonging to PDE and 100 from control group. Body Mass Index (BMI) z‐score was obtained as well as information about age, diet and socioeconomic level. Descriptive analyses were performed and a logistic regression model was done.Results: Overweight and obesity prevalence in PDE group was 13.9% and 6.5% respectively whereas in the control group were of 10% and 6%. A significant association could not be found between overweight (OR= 1.2, p=0.65) and obesity (OR=0.83, p=0.72) and belonging to the program. It was observed that as the socioeconomic index increases the probability of shift from a normal weight status to overweight was 3.5 times bigger in socioeconomic tertile 3 in relation to tertile 1 (p=0.000) and 12.5 times for the shifting from overweight to obesity (p=0.001).ConclusionsNo association between to be beneficiary of the PDE and overweight and obesity was found. This is positive because the program was restructured in 2010 as part of a national obesity prevention and control program through guidelines for the sale of food and beverages in schools.Supported by FOMIX SLP COPOCyT Project FMSLP‐213‐CO2‐208475
Associations of Dietary Carbohydrate Quality (CQ) with Daily Interstitial Glucose Patterns in Community‐Dwelling Individuals: a Pilot Study
Authors: McCrory Megan , Amankwaah Akua 
Published: June 2021

BackgroundIn controlled feeding studies, daily glucose patterns assessed by continuous glucose monitoring (CGM) reflect overall dietary carbohydrate quality (CQ) and the pattern of carbohydrate intake. However, few studies in non‐diabetic, community‐dwelling individuals exist. The purpose of this study was to determine associations of dietary variables reflecting CQ with interstitial glucose patterns in community‐dwelling, non‐diabetic individuals consuming self‐selected diets. The study is ongoing and results from the first 5 participants who completed measurements at Purdue University are reported here.MethodsHealthy, non‐smoking adults (1 M/ 4 F; aged 33.2±10.9 y; BMI 25.6±4 kg/m2 (mean±SD)) wore a CGM (iPro2, Medtronic) for 24h and performed a multiple pass 24h dietary recall for the same day. Glucose peak (PK) and total area under the curve (AUC) were determined, and macronutrients, fiber (total, soluble and insoluble), glycemic index (GI) and glycemic load (GL) were calculated with Nutrition Data System for Research software version 2011.ResultsSoluble fiber (but not total or insoluble fiber) was inversely associated with glucose AUC (r= ‐0.82; p=0.086) and PK (r= ‐0.97; p=0.005), while GI and GL were positively associated with glucose AUC (r=0.80‐0.82; p=0.098‐0.086) and PK (r=.87‐88; p=0.057‐0.048). GL was not associated with glucose PK after controlling for energy intake (r=0.84; p=0.157), but soluble fiber remained associated with glucose PK after controlling for GI (r=‐0.95; p=0.048).ConclusionInterstitial glucose patterns assessed by CGM may reflect self‐selected dietary CQ.
Use of Online Collaborative Case Study Modules for Obesity Education
Authors: Bignell Whitney , Fischer Joan 
Published: June 2021

Nutrition curricula need to comprehensively address obesity management. Course time constraints may limit in‐depth coverage. Added online case studies can provide experiential learning and enhance coverage of learning objectives. Online collaborative case‐based learning modules (CBLM) on obesity management were tested in four nutrition/dietetics classes. Facilitated CBLMs, based on constructivism, included reflective essays, discussion boards, group activities, and self‐evaluation of learning. Students completed pretests one week prior to and posttests one week after modules. CBLM information and activities were released over three weeks, allowing practice of skills over time. This study presents data from an upper level dietetics class. We tested the hypothesis that a CBLM would have a greater impact on students' obesity knowledge and skills than a standard case study. Students were stratified based on first exam performance and randomized to groups of 5‐6 students to complete the CBLM or a standard case study focused on nutrition assessment of obesity. Forty‐five students completed pretests and posttests. Independent t‐tests revealed a greater mean increase in scores for CBLM than standard group (+7.9 and ‐0.6%, respectively, P = 0.03). Two‐way ANOVA showed that students with below‐mean pretest scores had a greater mean score increase with CBLM compared to a standard case study (+19.6 vs. +3.5%, P <0.001). There was no significant difference between standard and CBLM delivery among students with above‐mean pretest scores. In summary, a CBLM increased knowledge and skills of nutrition students compared to a standard case study.Source of Research Support: College of Family and Consumer Sciences, The University of Georgia
A Study of factors related with beverage intake of high school girls in Incheon area, Korea
Authors: Kim Young A , Jin Seonhwa 
Published: June 2021

The purpose of this study was to examine the current status and influencing factors of high school students' beverage intake and provide school meal management plan with correct data. 710 high school girls were surveyed in Incheon, one of 5 major cities in Korea.According to the type of their school, the students are divided into 2 groups. 50.1% from specialized high schools and 49.9% of general high school. The major type of family was nuclear family regardless of their type of high school. However, the percentage of students from a single‐parent family, students staying with their relatives, students from protective facilities was examined higher in specialized high school students group. And the ratio of students spent more than 3,000 won (about 3 USD) was examined higher in normal high school students group.The taste was top priority factor of both groups to choose beverage. The specialized high school group considered of advertisement and wrapping more than the general high school group did. Commonly, the most favored beverages were milk and milk products, and followed by fruit and vegetable juice, soda and caffeinated drinks. The general high school group recognized the caffeinated drinks better than the other group. Students from general high school intake more milk and milk product and less soda and caffeinated drink than the specialized high school group.Therefore, school meal management plan should consider about beverage, especially for specialized school students so does the nutrition education programs
Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Guidelines of Women during Breast Cancer Treatment
Authors: Di Pietro Patricia , Bavaresco Thaiany Piazera Fanni , dos Santos Rafaela , de Liz Sheyla , Cardoso Alyne , de Assis Maria Alice , Vieira Francilene 
Published: June 2021

Support: CNPq, CAPESWe investigated the anthropometrics, lifestyle and nutritional characteristics of women during breast cancer treatment to according with WCRF/AICR guidelines. This is a nonrandomized clinical trial, including an evaluation at baseline and after treatment (±12mo). The characteristics were evaluated according to WCRF/AICR guidelines. The data were analyzed using paired t test, Wilcoxon test or McNemar test. This study included 78 women, 46.1% of them reported breast feeding for more than 6mo. After the treatment increased the overweight resulting in significant increase of body mass index mean (+1.1kg) and waist circumference (+2.0cm). A significant increase (15.4%) in energy density of diet higher than 125kcal/100g was observed. A decrease of sedentary (5.1%), an increase (9.0%) in the red and processed meat intake (蠅500g/week) and increase (7.7%) in the consumption of plant foods (蠅400g/day), but not significant were found. Decreased the prevalence of consumption of alcoholic beverages (>15g/day) (2.6%), the sodium intake (>2.4g/day) (3.8%) and the use of dietary supplements (2.5%), however there were not significant differences. After the breast cancer treatment most women do not adhere to the recommendations of the WCRF/AICR as to overweight, waist circumference, sedentary and energy density of diet. Thus, nutritional education strategies should be conducted to encourage healthy lifestyles and improve the quality diet these patients.
The Effects of Folate Deficiency and Folic Acid Supplementation on Folate Absorption and Metabolism in a Mouse Model
Authors: Warzyszynska Joanna , Im David , Bloemen Nicolaas , Sohn Kyoung‐Jin , Kim Sung‐Eun , Zuchniak Anna , Aufreiter Susanne , O'Connor Deborah , Kim Young‐In 
Published: June 2021

The effects of folate deficiency and folic acid (FA) supplementation on folate absorption and metabolism have not been well established in vivo. We investigated the effects of folate deficiency and FA supplementation on gene expression of folate receptors/transporters and metabolic enzymes in a mouse model. Postweaning C57BL/6 mice were randomized to receive diets containing 0 (moderate folate deficiency), 2 (control) or 20 mg FA/kg of diet for 3 months. Gene expression was assessed by real‐time RT‐qPCR. Plasma folate and unmetabolized FA and hepatic and small intestinal folate concentrations accurately reflected the supplemental levels of FA (p‐trend<0.0001). Expression of the proton‐coupled folate transporter (Pcft), reduced folate carrier (Rfc) and folate receptor‐1 (Folr1) in the small intestine and Folr1 in the liver was inversely associated with the supplemental levels of FA (p‐trend<0.0001). The supplemental levels of FA were inversely associated with thymidylate synthase (Tyms) expression in the liver and serine hydroxymethyltransferase (Shmt1) expression in the small intestine (p‐trend<0.05) but were not associated with the expression of dihydrofolate reductase (Dhfr) or methylenetetrahydrofolate reductase (Mthfr) in either tissue. Our data suggest that folate deficiency and FA supplementation modulate expression of genes involved in folate absorption and metabolism, likely as a homeostatic mechanism. However, FA supplementation may also adversely influence folate absorption and metabolism by dysregulation of these pathways.Supported by CIHR MOP#106446
Low Status of Vitamin C Promotes Oxidative Stress in Healthy Adults
Authors: Waly Mostafa , Al Attabi Zaher , Guizani Nejib 
Published: June 2021

BackgroundSeveral studies have reported a significant reduction in non‐communicable diseases during adulthood by adopting a dietary regiment that is rich in dietary antioxidants.ObjectiveThe present study was conducted to assess the nutritional and biochemical status of vitamin C in healthy adults, and to measure their oxidative stress indices.Subjects and MethodsA cross‐sectional study included 200 healthy subjects (100 males and 100 females) were recruited for this study. The vitamin C intake was assessed by analyzing the study subjects' intake of antioxidants‐rich foods using a semi‐quantitative food frequency questionnaire. The serum levels of vitamin C and glutathione were determined using biochemical assay kits.ResultsThe male group had significantly higher intake of vitamin C as compared to the female group (P <0.05). Vitamin C and glutathione levels were higher in the sera of the male study subjects as compared to female group (P <0.05).ConclusionsThe daily intake of vitamin C of the male subjects was positively correlated to their serum levels of vitamin C and glutathione, indicating a potential improvement in the cellular redox status. This is consistent with previously published studies reporting a significant reduction in oxidative stress in relation to high status of vitamin C.
Antioxidant Status in Healthy Humans after Acute Consumption of Juçara Fruits (Euterpe edulis)
Authors: Di Pietro Patricia , Cardoso Alyne , Vieira Francilene , Boaventura Brunna , de Liz Sheyla , Borges Graciele , de Assis Maria Alice , Fett Roseane , da Silva Edson 
Published: June 2021

Source of support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).This study aimed evaluating the effect of acute consumption of juçara juice (Euterpe edulis) rich in anthocyanin on biomarkers of oxidative stress in healthy subjects. This cross‐over clinical trial used water as control. Eleven volunteers were evaluated 4 times, before consumption and 1h, 2h and 4h after the intake of juice or water. The parameters evaluated were: ferric reducing antioxidant potential (FRAP), uric acid, glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and lipid hydroperoxides (LH). Analyses of variance for repeated measures revealed a significant effect of this treatment on FRAP and GPx. A moderate correlation was observed between FRAP and uric acid (r = 0.31). A significant interaction between type of treatment and time on lipid oxidation (HL) was also found. After ingestion of juice, relative average changes showed within the 2nd hour maximum elevation in the enzymatic activities of SOD (34.3%), CAT (18%) and GPx (8.5%), was reached. The juçara juice ingestion showed effect on the for the FRAP and enzymatic activity of GPx and interaction of lipid peroxidation that decreased over time. Further studies that investigate the antioxidant properties of the fruit juçara in the human are needed.
Association between Intake of Fish and Shellfish and Milk and Dairy Products with Cardio Vascular Disease(CVD) Risk Factors in Middle‐Aged Female with Type 2 Diabetes(T2D)
Authors: Kim Hyesook , Park Seokyung , Yang Hyesu , Choi Young Ju , Huh Kap Bum , Chang Namsoo 
Published: June 2021

This study was aimed to examine the association between intake of fish and shellfish and milk and dairy products with CVD risk factors in 356 middle‐aged (40‐64 years) female with T2D. Dietary food intake was assessed by semiquantitative food frequency questionnaire method. The average daily intakes of fish and shellfish and milk and dairy products were 63.9 g and 127.5 g, respectively. After adjustment for age, body mass index and energy intake, multiple regression analysis showed that intake of fish and shellfish (p=0.0423) and milk and dairy products (p=0.0094) was negatively associated with serum triglyceride level. These results suggest that intake of fish and shellfish and milk and dairy products is associated with decreased CVD risk in middle‐aged female patients with T2D.[This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2013R1A1A2011544) and Brain Korea 21 Plus.]
Effect of Yoghurt and its Probiotics on Fecal Probiotic Content; a Randomized Controlled Trial
Authors: Ivey Kerry , Yang Rongchang , Ryan Una , Lin Szu‐Yu , Hodgson Jonathan , Prince Richard 
Published: June 2021

BackgroundDespite a long history of safe use and the incorporation of probiotics into current therapeutic guidelines, the ability of yogurt and its probiotics to colonize the gastrointestinal tract, the appropriate mode of administration in order to maximize probiotic efficacy remain uncertain.AimTo determine the effect of daily probiotic supplementation of Lactobacillus acidophilus La5 (La5) and Bifidobacterium animalis subsp lactis BB12 (BB12) from capsules and the whole food (yogurt) form, on faecal counts of La5, BB12, and total Bifidobacteria.MethodsFollowing a 3‐week washout period, 156 men and women over 55 y were randomized to a 6‐week double‐blinded parallel study. The four intervention groups were: A) probiotic yogurt plus probiotic capsules; B) probiotic yogurt plus placebo capsules; C) control milk plus probiotic capsules; and D) control milk plus placebo capsules. Results are presented as the median (IQR) number of bacteria per g feces.ResultsWhen compared to control milk, probiotic yoghurt supplementation increased the fecal content of both BB12 [control milk: 10 (1‐100) BB12/g; probiotic yogurt: 820 (4‐2,815); P<0.001] and to a lesser extent La5 [control milk: 95 (6‐222) La5/g; probiotic yogurt: 107 (23‐634) La5/g; P=0.035]. When compared to placebo capsules, probiotic capsules increased the fecal content of BB12 [control milk: 10 (1‐356) BB12/g; probiotic yogurt: 230 (14‐1,409); P<0.001], but did not alter La5 content (P>0.05).ConclusionIn relation to probiotic capsules, supplementation with probiotic bacteria from yogurt was more efficacious at increasing the number of beneficial bacteria residing in the gastrointestinal tract.
Novel Drug DCQ Induces Colon Cancer Cell Apoptosis Through HIF‐1α Pathway
Authors: Sougiannis Alexander‐Jacques , Saxena Arpit , Kaur Kamajeet , Depaepe Sarah , Fayad Raja 
Published: June 2021

Recent developments in the field of cancer genomics have shown transcription factor HIF‐1α as a major player in the survival and proliferation of colorectal tumors. Presence of hypoxic areas in tumors facilitate the differentiation and nuclear translocation of HIF‐1α which leads to transcription of hypoxic genes causing vascularization and metastasis of tumors. Hypoxia targeted drug engineering has led to significant advancements in cancer treatments as a method of directly utilizing the hypoxic regions against the tumor to cause cell death and inhibition of growth. Novel drug DCQ (2‐benzoyl‐3‐phenyl 6,7‐dichloroquinoxaline 1,4‐dioxide) has shown promising anti‐tumor results in‐vitro and in‐vivo. The purpose of this study was to utilize a tumor xenograft mouse model to investigate the effectiveness and mechanism of action of DCQ. Methods: 10 week old Balb/c mice were injected subcutaneously with 2 million CT‐29 cells and were monitored for tumor growth over 14 days. Then, mice were randomly assigned to two treatment groups: DCQ treatment given at 17mg/kg body weight and 100μL DMSO injection as control. Injections were given bi‐weekly over a four week period. At sacrifice, tumors were obtained and sectioned. Results: DCQ caused significant decrease in tumor weight (p<0.05) and final tumor area (p<0.05) at time of sacrifice than DMSO injected mice. Histological analysis showed increased total apoptotic area (p<0.05) in tumor tissue sections. Western blot analysis showed a decreased nuclear expression of HIF‐1α (p<0.05).ConclusionsDCQ increases tumor apoptosis through mechanisms involving down regulation of HIF‐1α. Future investigations will observe the effect of DCQ using APCmin/+ mouse model in a supplemental study.
Possible roles of CXCL17 in angiogenesis during tumor progression
Authors: Matsui Aya , Morikawa Shunichi , Ezaki Taichi 
Published: June 2021

Recently, chemokines have drawn more attention as important targets in cancer therapy from viewpoints of tumor metastasis and recruitment of immune suppressor cells. Our previous studies showed that CXCL17 expression by tumor cells enhanced the tumor growth in mice, and demonstrated that CXCL17 also induced migration of myeloid‐derived suppressor cells (MDSCs) into the tumors. In the present study, we focused on tumor blood vessels as one of responsible factors in the progression of CXCL17‐expressing tumors to clarify the effects of CXCL17 and neutrophil‐like MDSCs on tumor blood vessels. CXCL17‐expressing colon26cells (a mouse colon cancer cell line) injected subcutaneously into BALB/c mice, showed an increase in CD31+ endothelial cell areas and well‐maintained blood vessel meshworks compared with CXCL17‐nonexpressing control tumors. Moreover, the number of NG2+ pericytes increased in the tumor vessels of these CXCL17‐expressing tumors. Furthermore, CXCL17 was adopted in the chemotaxis assay to separate the neutrophil‐like MDSCs from mouse splenocytes. Tumor cells transplanted together with the CXCL17‐chemotactic neutrophil‐like MDSCs enhanced their tumor angiogenesis compared with these transplanted with irrelevant splenocytes. These results suggest that CXCL17 may induce the structural and functional changes in tumor blood vessels via controlling neutrophil‐like MDSCs.