bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, synthesis, and biological evaluation of phenyl-isoxazole-carboxamide derivatives as anticancer agents
Authors: Hawash Mohammed , Jaradat Nidal , Bawwab Noor , Salem Kamilah , Arafat Hadeel , Hajyousef Yousef , Shtayeh Tahrir , Sobuh Shorooq 
Published: December 2021

Abstract
The present study aimed to design and synthesize a series of phenyl-isoxazole-carboxamide derivatives and investigate their antitumor and antioxidant activities. The in vitro cytotoxic evaluation was conducted using the MTS assay against four cancer cell lines: hepatocellular carcinoma (Hep3B and HepG2), cervical adenocarcinoma (HeLa), breast carcinoma (MCF-7), in addition to the normal cell line (Hek293T). Besides, the antioxidant activity was evaluated using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. All obtained compounds were found to have potent to moderate activities against Hep3B and MCF-7 cancer cells lines, except compound 2e. It was found that compound 2a has potent activity against HeLa and Hep3B cancer cell lines with IC50 values of 0.91 and 8.02 µM, respectively. The IC50 dose range of the tested compounds against Hep3B was 5.96–28.62 µM, except for 2e, compared with doxorubicin, which has an IC50 value of 2.23 µM. Also, the IC50 value range of the compounds against Hek293T was 112.78–266.66 µM, compared with doxorubicin, which has an IC50 dose of 0.581 µM. The antioxidant activity of the synthesized compounds was weak, and compound 2d showed moderate activity against the DPPH enzyme with an IC50 value of 138.50 µM in comparison with Trolox, which has an IC50 dose of 37.23 µM.
The effect of operating parameters of hydrodynamic cavitation – assisted alkaline catalyzed transesterification of sunflower oil with methanol on the degree of triglyceride conversion
Authors: Adnađević Borivoj K. , Nikolić Ivan R. , Milenković Svetozar A. , Jovanović Jelena D. 
Published: December 2021

Abstract
The effect of operating parameters such as reaction mixture inlet pressure p
1 (101.3–1013.2 kPa), methanol to oil molar ratio M
1 (3–12), the concentration of catalyst C

c
(0.0–1.0 wt%), temperature T (25–50 °C) and the number of passes of the reaction mixture through the venturi type hydrodynamic cavitation reactor n (1–12) on alkali-catalyzed transesterification of sunflower oil with methanol assisted by hydrodynamic cavitation (ACTC) on the value of the degree of triglyceride conversion (DTC) was investigated. ACTC was performed by the venturi-type hydrodynamic cavitation reactor (VCR) of our construction. It was found that the values of DTC increase with the increase in p
1, M
1, C

c, and n, and decrease with the increase in T. Cavitation yield (CY) values were calculated. The ACTC was proved to be the simplest, fastest, and most highly energy-efficient current technology for the production of biodiesel.
Effect of microencapsulated chavil (Ferulago angulata) extract on physicochemical, microbiological, textural and sensorial properties of UF-feta-type cheese during storage time
Authors: Borhanpour Fatemeh , Sekhavatizadeh Seyed Saeed , Hosseinzadeh Saeid , Hasanzadeh Mahboobeh , Golmakani Mohammad-Taghi , Moharreri Morteza 
Published: December 2021

Abstract
Chavil (Ferulago angulata) extract (CE) and microencapsulated chavil extract (MCE) were added to UF- Feta-type Cheese. The aim of this study was to comprising CE and MCE on physicochemical and microbiological properties in cheese. The scanning electron microscope images demonstrate the MCE had elliptical shape. The average size diameter curve of the MCE revealed bimodal distribution with two peaks (1541 and 2222 nm) separately. The hardness value of MCE cheese (212.83 ± 17.63 g) was lower than that of CE (343.67 ± 25.53 g) because of canola oil used in the microencapsulation process. The MCE-cheese showed lower values of acidity (1.67%) in comparison with CE-cheese (1.87%). The viable numbers of Streptococcus thermophilus and Lactococcus lactis were equal among the samples (4.6–4.9 log10 CFU/g respectively). The acid degree value of MCE (2.07 ± 0.21%) and CE (1.83 ± 0.25%) cheese were nearly equal at the end of storage time.
Growth, weights, and measurements of female wild sheep from Iran
Authors: Valdez Raul , Bleich Vernon C. , Shahriary Eahsan 
Published: December 2021

Abstract
Wild sheep (Ovis spp.) are of conservation concern throughout the Middle East. Little is known, however, about the natural history or ecology of this taxon. To better understand size relationships among wild sheep occupying Iran, we analyzed results from 120 females collected from widely separated ecosystems. Morphometrics and body weights for all age categories of females occupying the Khosh-Yeilagh Wildlife Refuge in northeastern Iran were larger than those for the same age classes of females occupying Bamou National Park in southwestern Iran. Females from Bamou National Park, however, obtained adult body weight (x̅ = 25.8 ± 2.47 [SD] kg) at an earlier age than those from the Khosh-Yeilagh Wildlife Refuge (x̅ = 36.6 ± 3.21 kg). Ecological differences between these two areas suggest that net primary productivity, which is a function of numerous climatic and geographical factors, has been a primary force contributing to these results. Weights and measurements reported here provide the basic information for additional, more detailed research necessary to fully understand the evolutionary significance and management implications of these differences in body size and emphasize the conservation value of even the most basic natural history information.
Embedded three spinel ferrite nanoparticles in PES-based nano filtration membranes with enhanced separation properties
Authors: Ghanbari Davood , BandehAli Samaneh , Moghadassi Abdolreza 
Published: December 2021

Abstract
In this study, three types of ferrites nanoparticles including CoFe2O4, NiFe2O4, and ZnFe2O4 were synthesized by microwave-assisted hydrothermal method. The X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FESEM) were employed to analyze synthesized nanoparticles and fabricated membranes. The morphology of membrane surface was investigated by surface images. The ability of ferrite nanoparticles was evaluated to the separation of sodium salt and heavy metals such as Cr2+, Pb2+, and Cu2+ from aqueous solutions. The modified membrane showed the enhancement of membrane surface hydrophilicity, porosity, and mean pore size. The results revealed a significant increase in pure water flux: 152.27, 178, and 172.68 L·m−2·h−1 for PES/0.001 wt% of CoFe2O4, PES/0.001 wt% NiFe2O4, and PES/0.001 wt% ZnFe2O4 NPs, respectively. Moreover, Na2SO4 rejection was reached 78% at 0.1 wt% of CoFe2O4 NPs. The highest Cr (II) rejection obtained 72% for PES/0.001 wt% of NiFe2O4 NPs while it was 46% for the neat PES membrane. The Pb(II) rejection reached above 75% at 0.1 wt% of CoFe2O4 NPs. The Cu(II) rejection was obtained 75% at 0.1 wt% of CoFe2O4 NPs. The ferrite NPs revealed the high potential of heavy metal removal in the filtration membranes.
Diverse wave propagation in shallow water waves with the Kadomtsev–Petviashvili–Benjamin–Bona–Mahony and Benney–Luke integrable models
Authors: Younas Usman , Seadawy Aly R. , Younis Muhammad , Rizvi Syed T. R. , Althobaiti Saad 
Published: December 2021

Abstract
The shallow water wave model is one of the completely integrable models illustrating many physical problems. In this article, we investigate new exact wave structures to Kadomtsev–Petviashvili–Benjamin–Bona–Mahony and the Benney–Luke equations which explain the behavior of waves in shallow water. The exact structures are expressed in the shapes of hyperbolic, singular periodic, rational as well as solitary, singular, shock, shock-singular solutions. An efficient computational strategy namely modified direct algebraic method is employed to construct the different shapes of wave structures. Moreover, by fixing parameters, the graphical representations of some solutions are plotted in terms of three-dimensional, two-dimensional and contour plots, which explain the physical movement of the attained results. The accomplished results show that the applied computational technique is valid, proficient, concise and can be applied in more complicated phenomena.
Recovery of continuous functions of two variables from their Fourier coefficients known with error
Authors: Pozharska K.V. , Pozharskyi A.A. 
Published: December 2021

In this paper, we continue to study the classical problem of optimal recovery for the classes of continuous functions. The investigated classes $W^{\psi}_{2,p}$, $1 \leq p < \infty$, consist of functions that are given in terms of generalized smoothness $\psi$. Namely, we consider the two-dimensional case which complements the recent results from [Res. Math. 2020, 28 (2), 24-34] for the classes $W^{\psi}_p$ of univariate functions.
As to available information, we are given the noisy Fourier coefficients $y^{\delta}_{i,j} = y_{i,j} + \delta \xi_{i,j}$, $\delta \in (0,1)$, $i,j = 1,2, \dots$, of functions with respect to certain orthonormal system $\{ \varphi_{i,j} \}_{i,j=1}^{\infty}$, where the noise level is small in the sense of the norm of the space $l_p$, $1 \leq p < \infty$, of double sequences $\xi=( \xi_{i,j} )_{i,j=1}^{\infty}$ of real numbers. As a recovery method, we use the so-called $\Lambda$-method of summation given by certain two-dimensional triangular numerical matrix $\Lambda = \{ \lambda_{i,j}^n \}_{i,j=1}^n$, where $n$ is a natural number associated with the sequence $\psi$ that define smoothness of the investigated functions. The recovery error is estimated in the norm of the space $C ([0,1]^2)$ of continuous on $[0,1]^2$ functions.
We showed, that for $1\leq p < \infty$, under the respective assumptions on the smoothness parameter $\psi$ and the elements of the matrix $\Lambda$, it holds \[ \Delta( W^{\psi}_{2,p}, \Lambda, l_p)= \sup\limits_{ y \in W^{\psi}_{2,p} } \sup\limits_{\| \xi \|_{l_p} \leq 1} \Big\| y - \sum\limits_{i=1}^{n} \sum\limits_{j=1}^{n} \lambda_{i,j}^n ( y_{i,j} + \delta \xi_{i,j}) \varphi_{i,j} \Big\|_{C ([0,1]^2)} \ll \frac{ n^{\beta + 1 - 1/{p}}}{\psi(n)}.\]
Students’ Perceptions on Online Peer Feedback Practice In EFL Writing
Authors: Putra I Gede Krisna Meialldy , Santosa Made Hery , Pratiwi Ni Putu Astiti 
Published: December 2021

ABSTRACTThis study investigated the implementation of online peer feedback practice, the students’ perceptions toward online peer feedback practice, and the students’ challenges toward online peer feedback practice. The study employed a mixed-method design with SMA PGRI Blahbatuh students as the population, while the sample was 132 students. The data were collected through observing the online classes using an observation checklist, conducting a survey using a questionnaire, and conducting an interview using an interview guide through focus group discussion. The study’s findings imply several strengths and weaknesses in the online peer feedback practice. It was also revealed that the students had positive perceptions toward the online peer feedback practice. Meanwhile, the interview results revealed several contradictory results regarding the students’ challenges. The students preferred the teacher’s feedback after the practice since it would make them feel safe. The students also suggested anonymous peer feedback practice since they could give the comments honestly, with details, and specifics. Through this study, students can learn to improve their skills in communicating and collaborating with their peers. The study also provided the teacher information to create more effective and efficient online peer feedback practice. ABSTRAKPenelitian ini didesain untuk menyelidiki penerapan praktik umpan balik rekan secara daring, persepsi siswa terhadap praktik umpan balik rekan secara daring, dan tantangan siswa terhadap praktik umpan balik rekan secara daring. Penelitian ini menggunakan desain kombinasi dengan siswa SMA PGRI Blahbatuh sebagai populasi, sedangkan sampelnya hanya 132 siswa. Pengumpulan data dilakukan melalui observasi kelas online menggunakan lembar observasi, survei menggunakan kuesioner, dan wawancara menggunakan pedoman wawancara melalui diskusi kelompok terfokus. Temuan penelitian menyiratkan bahwa ada beberapa kekuatan dan kelemahan dalam praktik umpan balik rekan secara daring. Terungkap pula bahwa siswa memiliki persepsi positif terhadap praktik umpan balik rekan secara daring. Sementara itu, hasil wawancara mengungkapkan beberapa hasil yang kontradiktif terkait tantangan siswa. Siswa lebih menyukai masukan dari guru setelah latihan karena akan membuat mereka merasa lebih aman. Para siswa juga menyarankan praktik umpan balik rekan anonim karena mereka dapat memberikan komentar dengan jujur, dengan detail, dan spesifik. Melalui penelitian ini, siswa dapat belajar meningkatkan keterampilannya dalam berkomunikasi dan berkolaborasi dengan teman sebayanya. Penelitian ini juga memberikan informasi kepada guru untuk menciptakan praktik umpan balik teman secara daring yang lebih efektif dan efisien.
Strategy Preference in Listening: A Profile of EFL Students to Answer TOEFL Test
Authors: Hidayanti Ika , Zuhairi Alfan , Kurniasih Kurniasih 
Published: December 2021

ABSTRACTMeasuring students’ English ability in most universities would be counted from their passing grade on the Test of English as A Foreign Language (TOEFL). Listening to natives is considered a complicated section to answer among the three sections. Thus, EFL learners should focus on attainment strategies to answer the TOEFL preparation test. The current study examines students’ profile of attainment strategy use and how usage of this strategy differs by gender. The sixth English semester students, faculty of education at Universitas Islam Malang, were required to fill out the questionnaire of strategies used to answer the TOEFL. Utilizing the descriptive and independent t-test, the findings reveal that students deployed the strategies at a moderate level. Further, female students used all the strategies more often and significantly differently than their counterparts. This implies that the use of strategies could ease them in obtaining good scores in listening.ABSTRAKMengukur ketrampilan bahasa Inggris mahasiswa di sebagian besar universitas akan dihitung dari nilai kelulusan mereka pada tes TOEFL (Test of English as a Foreign Language). Diantara ketiga bagian pada tes TOEFL, tes pada bagian I (Listening) dianggap sebagai tes yang sulit untuk dijawab. Sehingga, mahasiswa diharapkan bisa fokus dan bisa menggunakan strategi tepat ketika menjawab tes TOEFL. Penelitian ini ditujukan untuk mengetahui bagaimana profil penggunaan strategi menjawab tes TOEFL dan mengidentifikasi perbedaan penggunaaan oleh mahasiswa laki-laki dan perempuan. Mahasiswa semester enam jurusan Pendidikan Bahasa Inggris Fakultas Pendidikan, Universitas Islam Malang dilibatkan dalam penelitian ini dan mereka diminta mengisi kuesioner strategi menjawab tes TOEFL. Dengan menggunakan analisis dan Uji T-tes, temuan menunjukkan bahwa mahasiswa menggunakan strategi dalam kategori sedang. Hasil selanjutnya mengindikasikan bahwa mahasiswa perempuan sering menggunakan strategi dan berbeda secara signifikan dari mahasiswa laki-laki. Hal ini berarti bahwa penggunaan strategi dapat memudahkan mahasiswa tersebut untuk mendapatkan nilai bagus.
AI-driven Optimization in Healthcare: the Diagnostic Process
Authors: Lyon Jérôme Yves , Bogodistov Yevgen , Moormann Jürgen 
Published: December 2021

Purpose: Process optimization in healthcare using artificial intelligence (AI) is still in its infancy. In this study, we address the research question “To what extent can an AI-driven chatbot help to optimize the diagnostic process?”
Design / Method / Approach: First, we developed a mathematical model for the utility (i.e., total satisfaction received from consuming a good or service) resulting from the diagnostic process in primary healthcare. We calculated this model using MS Excel. Second, after identifying the main pain points for optimization (e.g., waiting time in the queue), we ran a small experiment (n = 25) in which we looked at time to diagnosis, average waiting time, and their standard deviations. In addition, we used a questionnaire to examine patient perceptions of the interaction with an AI-driven chatbot.
Findings: Our results show that scheduling is the main factor causing issues in a physician’s work. An AI-driven chatbot may help to optimize waiting time as well as provide data for faster and more accurate diagnosis. We found that patients trust AI-driven solutions primarily when a real (not virtual) physician is also involved in the diagnostic process.
Practical Implications: AI-driven chatbots may indeed help to optimize diagnostic processes. Nevertheless, physicians need to remain involved in the process in order to establish patient trust in the diagnosis.
Originality / Value: We analyze the utility to physicians and patients of a diagnostic process and show that, while scheduling may reduce the overall process utility, AI-based solutions may increase the overall process utility.
Research Limitations / Future Research: First, our simulation includes a number of assumptions with regard to the distribution of mean times for encounter and treatment. Second, the data we used for our model were obtained from different papers, and thus from different healthcare systems. Third, our experimental study has a very small sample size and only one test-physician.
Paper type: Empirical
Wayfinding design: Sistema de sinalização para o Mercado Central de Pelotas/RS
Authors: Santos Fick Nathália , Klumb Arnoni Rafael 
Published: December 2021

O artigo aborda o desenvolvimento e resultados do projeto realizado como componente prático do Trabalho de Conclusão de Curso, no qual foi desenvolvido um Sistema de Sinalização para o Mercado Central de Pelotas/RS, considerando os conceitos e práticas relacionadas ao Design de Sinalização e Wayfinding Design. Justifica-se por contribuir para a orientação espacial do local através da organização das informações do ambiente por meio de elementos visuais que auxiliam no deslocamento e contribuem para o bem-estar e segurança dos usuários do Mercado. Utilizou-se a metodologia proposta por Gibson (2009) para o desenvolvinto de estratégias de Wayfinding em projetos de sinalização. Como resultado, obteve-se uma proposta de Sistema de Sinalização e a concepção do Manual de Sinalização e Wayfinding.
Comparative pharmacokinetic study of bicalutamide administration alone and in combination with vitamin D in rats
Authors: Shi Wenjing , Di Haixiao , Pang Bo , Jin Huixin , Liu Hongtao , Qiu Bo , Ren Bingnan , Pang Guoxun 
Published: December 2021

Abstract
Bicalutamide (BCL) has been approved for treatment of advanced prostate cancer (Pca), and vitamin D is inevitably used in combination with BCL in Pca patients for skeletal or anti-tumor strategies. Therefore, it is necessary to study the effect of vitamin D application on the pharmacokinetics of BCL.
We developed and validated a specific, sensitive and rapid UHPLC–MS/MS method to investigate the pharmacokinetic behaviours of BCL in rat plasma with and without the combined use of vitamin D. Plasma samples were extracted by protein precipitation with ether/dichloromethane (2:1 v/v), and the analytes were separated by a Kinetex Biphenyl 100A column (2.1 × 100 mm, 2.6 μm) with a mobile phase composed of 0.5 mM ammonium acetate (PH 6.5) in water (A) and acetonitrile (B) in a ratio of A:B = 35:65 (v/v). Analysis of the ions was run in the multiple reactions monitoring (MRM) mode. The linear range of BCL was 5–2000 ng mL−1. The intra- and inter-day precision were less than 14%, and the accuracy was in the range of 94.4–107.1%. The mean extraction recoveries, matrix effects and stabilities were acceptable for this method. The validated method was successfully applied to evaluate the pharmacokinetic behaviours of BCL in rat plasma. The results demonstrated that the pharmacokinetic property of BCL is significantly affected by combined use of vitamin D, which might help provide useful evidence for the clinical therapy and further pharmacokinetic study.
The influence of special physical fitness of athletes on the level of technique of playing beach volleyball
Authors: Hunchenko Valeriy , Solovey Oleksandr , Solovey Dmytro , Malojvan Yaroslav , Yakovenko Artem , Wnorowski Krzysztof 
Published: December 2021

Background and Study Aim. Aim is to determine the influence of the components of special physical training on the effectiveness of certain elements of the game technique during the competitive activities of beach volleyball athletes.
Material and methods. The study involved athletes (n = 20, age - 17-21 years, experience - 8-9 years), who are engaged in beach volleyball (Kherson, Ukraine). Experts (n = 5, work experience - over 20 years) from among the leading volleyball specialists were involved. Training sessions were conducted according to the author’s structure and content of special physical training (preparatory period of the annual cycle). The author's program was to increase the volume of athletic work by 10% (selective classes and integrated work) and 17% (complex classes). The classes used a developed special training device. The device is designed to practice practical game skills. The load at the first stage was 70-80% of the maximum. The load in the second stage was 80-90% of the maximum.
Results. Significant (p <0.05) development of explosive power, speed and agility was revealed. There is a significant (p <0,05) increase: in the number of jump serve and spike; improving the quality/number of serve and attack; improving the quality of passing and the number of blocks.
Conclusions. The proposed structure and content of special physical training and exercises on a special simulator have significantly increased the level of development of physical qualities. The athlete training program helped to improve the effectiveness of certain technical actions during competitive activities.
Istirātījiyyatu al-Ta’allum al-Dzāti fī Ta’līmi Mahārati al-Kitābati ‘abra al-Ta’allum al-Iliktronī
Authors: Zawawi Moh 
Published: December 2021

Pembelajaran di era digital mengharuskan pengajar dan pembelajar untuk mengenal teknologi. Kemajuan sebuah instutusi Pendidikan saat ini juga dapat diukur dari fasilitas yang mereka sajikan. E-learnimg menjadi salah satu fasilitas yang disediakan oleh institusi Pendidikan yang aplikasinya sangat mendukung untuk proses pembelajaran. Metode penelitian ini adalah deskriptif kualitatif. Penelitian ini bertujuan untuk mendeskripsikan penerapan strategi pembelajaran mandiri dalam pembelajaran maharah kitabah melalui platform e-learning serta kelebihan dan kekurangnya. Implementasi dari pembelajaran mandiri ini meliputi tiga tahap yaitu perencanaan, pelaksanaan dan evaluasi. Kelebihan penggunaan e-learning adalah melatih mahasiswa untuk mengatur waktu dan bertanggungjawab, mahasiswa dapat mengambil pelajaran, pembelajaran mandiri lebih efktif. Sedangkan kekurangnya adalah boros kuota, dosen merasa kesulitan dalam memberikan feed back atas tugas mahasiswa dan tidak ada tatap muka.