bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Picture this”- Patients’ Drawings of Non-Muscle Invasive Bladder Cancer: A Novel Method to Help Understand How Patients Perceive Their Condition
Authors: Richards Helen L. , Sweeney Paul , Corscadden Rebekah , Carr Chelsea , Rukundo Aphie , Fitzgerald Jill , O’Connor Charles , Fortune Dónal G. 
Published: April 2021

BACKGROUND: There is a paucity of data regarding patient experiences of living with non-muscle-invasive bladder cancer (NMIBC). OBJECTIVES: To investigate patients’ beliefs about NMIBC utilising both a well-established verbal/linguistic method, the Brief Illness Perception Questionnaire (B-IPQ) in addition to a novel visual/perceptual method, that is, asking patients to draw their bladder as it is now and as they perceive it will be in the future. METHODS: Cross-sectional study of patients with NMIBC. Patients completed: (i) the B-IPQ, and (ii) 2 drawings of their bladder: as they perceived it currently and as they perceived it would look in 5 years’ time. RESULTS: A total of 118 patients completed the B-IPQ, of which 96 produced 2 bladder drawings. Forty-seven per cent of patients depicted no change in their bladder across time, 35% depicted improvements, while 18% drew their NMIBC as deteriorating between the two time points. Patients who drew their NMIBC worsening over time reported significantly stronger beliefs in the severity of current consequences from their NMIBC (F(2,94) = 9.07, p < 0.001, m = 5.68, 95% CI 4.38–6.88) and greater current concerns about their NMIBC (F(2,94) = 6.17, p < 0.01, m = 7.06, 95% CI 5.47–8.66). This was unrelated to cancer grade, cancer stage, treatment or demographic variables. CONCLUSION: This is the first study to explore beliefs about NMIBC in a sample of patients with NMIBC attending routine clinics using both a well-established and a novel method of assessing patients’ perceptions. Results highlight the usefulness of a simple non-verbal technique, in identifying patients’ concerns about the condition. Almost one fifth of patients with NMIBC may experience significant concerns about the worsening of their condition, which appear to be independent of demographic, histopathological, and treatment related variables. Further exploration of the psychological concerns of individuals with NMIBC is required in order to appropriately plan for needs led multidisciplinary approach in their care.
Rain Measurement Simulation Using the Hall Effect Flow-Meter
Authors: Sirenden Bernadus Herdi 
Published: April 2021

The sensor analysis or flow-meter measuring instrument has been successfully carried out on the signal output to see the stability or accuracy of a measurement. The flowmeter measurement value was analyzed using a rainfall simulator. The rainfall intensity value will then be predicted using the Kalman filter. Kalman filters can predict various data or output signals so that the measurement results can be more stable and accurate. This research methodology consists of several stages, namely the stages of literature study, designing research tools and components, designing systems, making or assembling tools, testing all components, programs and testing the flow-meter output signal record. The flowmeter is controlled by the Arduino Nano microcontroller. Tests were carried out in this study ten times, with a time span of 60 seconds for each experiment. The increase in water flow was detected by the flow-meter which was then captured by the hercules application and the data was then copied to Ms. Excel. After the rainfall intensity value is obtained, the value will be estimated using the Kalman filter. The estimation results will show the stability and accuracy value of the flow-meter.
Influence Of Organizational Culture And Work Ethics On Employee Performance Transportation Department In Merangin Regency
Authors: EBGC Herawati , EBGC Khairun A. Roni , EBGC Wasis Mundi 
Published: April 2021

Employee performance can be influenced by many factors, as well as in the Merangin District Transportation Office. This research examines the existing organizational culture and employee work ethics on 30 employee performance honorary staff. This research also wants to see which variable has the most influence on employee performance. This study uses a survey method in which the population and sample in this study are the same sizes or saturated sampling. The analytical tool in this study is SPSS with Multiple Linear Regression. The results found that organizational culture and work ethic enhance employee performance simultaneously and partially. Meanwhile, the contribution value of the two dependent variables on the independent variable was 53.4%. Further research can continue by adding other variables or can use different methods such as qualitative or mixed methods.
Persuasive Communication And Work Effectiveness Enhancing Performance Of Employees In DPRD Merangin Regency
Authors: EBGC Supriyati , EBGC Misra Yeni , EBGC Ira Yumita , EBGC Darham 
Published: April 2021

Persuasive communication and good work effectiveness could enhance employee performance. The purpose of this studied to determine and analyze variables of the persuasive communication and work effectiveness that affect the performance of the DPRD office staff Merangin Regency. This survey used the survey sampling of 45 office staff with multiple Linear Regression. The results that partially and simultaneously showed the influence of persuasive communication and work effectiveness variables on employee performance and the persuasive communication variables had more enhancing than work effectiveness variables. The value of R is 0.754 or 75.4% further research can examine qualitative methods or mixed methods or can use other variables so that employee performance can continue to be improved.
IN A UNIFIED UNDERSTANDING OF SCIENCE AND PRACTICE
Authors: Антонов Игорь , Галиев Фарит 
Published: April 2021

Chairman of the Investigative Committee of the Russian Federation A.I. Bastrykin and his co-authors have published a significant book on law enforcement operations. See: Law Enforcement Operations. Scientific and practical commentary (article-by-article) on the Federal Law / A.I. Bastrykin, V.M. Egorshin, S.I. Zakhartsev, Yu.Yu. Ignaschenkov, I.N. Kondrat, D.V. Rivman, V.P. Salnikov, A.G. Khabibulin, A.V. Chess; under total. ed. A.I. Bastrykin. M. : Jurlitinform, 2020

The commentary on the Federal Law “On Law Enforcement Operations” pre- pared by reputable scientists and practitioners is being reviewed. The reviewers conclude that the book is significant and useful both for practical workers (operatives, investigators, judges, prosecutors) and general public. Specific provisions are given that show that the reviewed commentary is deeper and better than similar works.
SIDNEY WEBB: TO THE ORIGINS OF THE CONCEPT OF THE WELFARE STATE
Authors: ЛУШНИКОВ Андрей Михайлович 
Published: April 2021

The purpose of the article is to review the biography and scientific heritage of the lawyer, scientist, state leader S. Webb. The stages of formation of S. Webb's worldview are analyzed. Methods: the research is based on historical and comparative legal methods. Results: it is argued that it is largely thanks to this scientist and politician that Great Britain adapted continental socialism in its more liberal and parliamentary version. The author's analysis of the individual researches of S. Webb is given, in which the contours of the future concept of the welfare state are largely outlined. The conclusion is made that S. Webb can be considered one of the ideologists of the modern model of the welfare state.
Histological and immunohistochemical evaluation in patients who underwent maxillary sinus lifting surgery using autogenous or heterogenous bone. A clinical randomised trial
Authors: Griza Geraldo Luiz , Okamoto Roberta , Colet Daniela , Conci Ricardo Augusto , Magro-Filho Osvaldo 
Published: April 2021

Objectives: This study evaluated, through histological and immunohistochemical analysis the bone formation and remodeling after a maxillary sinus lift. Material and methods: 25 patients from 41 to 65 years of age, with inadequate bone volume in the posterior maxillary region and remaining native bone less than or equal to 5 mm, as measured radiographically, were selected and underwent maxillary sinus lift surgery, through the open technique. They were distributed in 3 groups: A - particulate, autogenous bone, AB - autogenous and heterogeneous bone, and B - only heterogeneous bone. Six months after this intervention, the patients were submitted to a surgery for the installation of implants and concomitant removal of the grafted bone sample from the surgical site. Results: The histological evaluation showed bone formation in the three groups, with presence of mature bone. In groups B and AB, the presence of granules of the biomaterial surrounded by bone tissue was observed. A statistical analysis showed significant difference (ANOVA p=0,002), suggesting greater bone formation in the autogenous group. In an immunohistochemical evaluation, no statistically significant differences were observed in the comparison between the experimental groups (A, B and AB), as well as in the proteins analyzed (OC: p= 0.657; VEGF: p= 0,133; TRAP: p= 0.163). Conclusion: The use of Bio-Oss ®, whether or not associated to autogenous bone, for a maxillary sinus lift through the side window technique results in bone repair. A predictable amount of bone formation is attained when this osteoconductive biomaterial is used.
Sabri F. Ülgener'in “İktisadi Çözülmenin Ahlak ve Zihniyet Dünyası" Eseri Hakkında Bir İnceleme
Authors: DAĞ Muhammed 
Published: April 2021

İktisat tarihi alanında önemli bir yazar olan alan Sabri F. Ülgener, aynı zamanda farklı disiplinlere ilgi göstermiş, farklı bilim dallarında eğitim görmüş önemli bir sosyal bilimcidir. Ülgener, Türkiye’de, kapitalist gelişmeye ulaşmama, girişimcilik kültürünün gelişmemesi, iktisadi gerileme ile zihniyet arasında ilişkinin boyutu ve kapsamı üzerinde özelikle durmuştur. Ülgener’in “İktisadi Çözülmenin Ahlak ve Zihniyet Dünyası” başlıklı eseri de bu konulara eğilen bir çalışmadır. Dönem ile ilgili edebi ve dinsel kaynakları kullanan Ülgener, iktisat ahlakı, iktisadi zihniyet ve çözülme kavramlarını inceler. Batı dünyasının ilerlemesine karşılık Doğu dünyasının yaşadığı iktisadi gerilemenin maddi ve manevi nedenlerinin birlikte önemsemesi gerektiğini savunur.
Ülgener’e göre, Osmanlı’nın gerilemesi siyasi ve askeri olmaktan ziyade, daha çok fikri, sanatsal ve eğitim bakımından bir ortaçağ ahlakına dönüşmekle ilgiliydi. Ortaçağ ahlakı az ile yetinen, kapalı bir yaşam biçimini dayatır. Ekonomik gerileme, norm ve hareket kurallarının bütünü olan ahlak ve kişinin davranışlarına yön veren değer, inançların toplamı olan zihniyetle yakından ilgilidir. Bu çalışmada Ülgener’in “İktisadi Çözülmenin Ahlak ve Zihniyet Dünyası” başlıklı eseri merkezinde ekonomik gerileme, girişimcilik kültürünün gelişmemesinin zihniyet kökleri ve bunların sonuçları üzerinde durulmaya çalışılmıştır
Hypoxia Constructing the Prognostic Model of Colorectal Adenocarcinoma and Related to the Immune Microenvironment
Authors: Zhang Yuanyuan , Yang Feng , Peng Xiaohong , Li Xiaoyu , Luo Na , Zhu Wenjun , Fu Min , Li Qianxia , Hu Guangyuan 
Published: April 2021

Background: Hypoxia is a common phenomenon in solid tumors, which plays an important role in tumor proliferation, apoptosis, angiogenesis, invasion and metastasis, energy metabolism and chemoradiotherapy resistance. However, comprehensive analysis of hypoxia markers in colorectal adenocarcinoma (COAD) is still lacking. And there is a need for mechanism exploration and clinical application.Methods: The gene expression, mutation and clinical data of COAD were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, respectively. Tumor samples from TCGA were randomly divided into the training and internal validation groups, while tumor samples from GEO were used as the external validation group. Univariate COX—LASSO—multivariate COX method was applied to construct the prognostic model. We clustered all TCGA tumor samples into high, medium and low hypoxia groups, evaluated the correlation between hypoxia degree and immunoactivity, and explored the combined effect of mutation for common target genes and model riskscore on survival in COAD patients. Finally, we developed a dynamic nomograph App online for direct clinical application and carried out multiple validations of the prognostic model.Results: Our hypoxia-related prognostic model for COAD patients is accurate and has been successfully validated internally and externally. Single Sample Gene Set Enrichment Analysis (ssGSEA) and Gene Set Enrichment Analysis (GSEA) results suggest that for COAD patients with higher hypoxia, the stronger the associated immunosuppressive activity, providing a possible mechanism for the lower survival rate. Finally, the dynamic nomograph App online enhances the clinical translational significance of the study.Conclusion: In this study, an accurate prognostic model for COAD patients was established and validated. In addition, our innovative findings include correlations between hypoxia levels and immune activity, as well as an in-depth exploration of common target gene mutations.
Outcomes of Patients With ST-Segment Elevation Myocardial Infarction Admitted During COVID-19 Pandemic Lockdown in Germany – Results of a Single Center Prospective Cohort Study
Authors: Rattka Manuel , Stuhler Lina , Winsauer Claudia , Dreyhaupt Jens , Thiessen Kevin , Baumhardt Michael , Markovic Sinisa , Rottbauer Wolfgang , Imhof Armin 
Published: April 2021

Objective: Since the outbreak of the COVID-19 pandemic, healthcare professionals reported declining numbers of patients admitted with ST-segment myocardial infarction (STEMI) associated with increased in-hospital morbidity and mortality. However, the effect of lockdown on outcomes of STEMI patients admitted during the COVID-19 crisis has not been prospectively evaluated.Methods: A prospective, observational study on STEMI patients admitted to our tertiary care center during the COVID-19 pandemic was conducted. Outcomes of patients admitted during lockdown were compared to those patients admitted before and after pandemic-related lockdown.Results: A total of 147 patients were enrolled in our study, including 57 patients in the pre-lockdown group (November 1, 2019 to March 20, 2020), 16 patients in the lockdown group (March 21 to April 19, 2020), and 74 patients in the post-lockdown group (April 20 to September 30, 2020). Patients admitted during lockdown had significantly longer time to first medical contact, longer door-to-needle-time, higher serum troponin T levels, worse left ventricular end-diastolic pressure, and higher need for circulatory support. After a median follow-up of 142 days, survival was significantly worse in STEMI patients of the lockdown group (log-rank: p = 0.0035).Conclusions: This is the first prospective study on outcomes of STEMI patients admitted during public lockdown amid the COVID-19 pandemic. Our results suggest that lockdown might deteriorate outcomes of STEMI patients. Public health strategies to constrain spread of COVID-19, such as lockdown, have to be accompanied by distinct public instructions to ensure timely medical care in acute diseases such as STEMI.
Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans
Authors: van Keulen Danielle , van Koeverden Ian D. , Boltjes Arjan , Princen Hans M. G. , van Gool Alain J. , de Borst Gert J. , Asselbergs Folkert W. , Tempel Dennie , Pasterkamp Gerard , van der Laan Sander W. 
Published: April 2021

Background and Aims:Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants inOSMand its receptors,OSMRandLIFR, on overall plaque vulnerability, plaque phenotype, intraplaqueOSMRandLIFRexpression, coronary artery calcification burden and cardiovascular disease susceptibility.Methods and Results:We queried Genotype-Tissue Expression data and found that rs13168867 (C allele) was associated with decreasedOSMRexpression and that rs10491509 (A allele) was associated with increasedLIFRexpression in arterial tissues. No variant was significantly associated withOSMexpression.We associated these two variants with plaque characteristics from 1,443 genotyped carotid endarterectomy patients in the Athero-Express Biobank Study. After correction for multiple testing, rs13168867 was significantly associated with an increased overall plaque vulnerability (β = 0.118 ± s.e. = 0.040,p= 3.00 × 10−3, C allele). Looking at individual plaque characteristics, rs13168867 showed strongest associations with intraplaque fat (β = 0.248 ± s.e. = 0.088,p= 4.66 × 10−3, C allele) and collagen content (β = −0.259 ± s.e. = 0.095,p= 6.22 × 10−3, C allele), but these associations were not significant after correction for multiple testing. rs13168867 was not associated with intraplaqueOSMRexpression. Neither was intraplaqueOSMRexpression associated with plaque vulnerability and no knownOSMReQTLs were associated with coronary artery calcification burden, or cardiovascular disease susceptibility. No associations were found for rs10491509 in theLIFRlocus.Conclusions:Our study suggests that rs1316887 in the OSMR locus is associated with increased plaque vulnerability, but not with coronary calcification or cardiovascular disease risk. It remains unclear through which precise biological mechanisms OSM signaling exerts its effects on plaque morphology. However, the OSM-OSMR/LIFR pathway is unlikely to be causally involved in lifetime cardiovascular disease susceptibility.
Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients
Authors: Chan Ka Lung , Feng Xueyan , Ip Bonaventure , Huang Shangmeng , Ma Sze Ho , Fan Florence S. Y. , Ip Hing Lung , Huang Li’an , Mok Vincent C. T. , Soo Yannie O. Y. , Leung Thomas W. , Leng Xinyi 
Published: April 2021

BackgroundThe risk of recurrent stroke following a minor stroke or transient ischemic attack (TIA) is high, when inflammation might play an important role. We aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) in predicting composite cardiovascular events in patients with minor stroke and TIA.MethodsConsecutive patients with acute minor stroke or TIA admitted within 24 h of symptoms onset during a 5-year period in a prospective stroke registry were analyzed. We calculated the NLR dividing absolute neutrophil count by absolute lymphocyte count tested within 24 h of admission. NLR ≥4th quartile was defined as high NLR. A composite outcome was defined as stroke, acute coronary syndrome or vascular death within 1 year. We investigated associations between NLR and the composite outcome in univariate and multivariate analyses, among all patients and in those aged over 60 years (i.e., older patients).ResultsOverall, 841 patients (median age 68 years; 60.4% males) were recruited. No significant independent association was found between NLR and the composite outcome in multivariate analysis in the overall cohort. Among the 612 older patients (median age 73 years; 59.2% males), the median NLR was 2.76 (interquartile range 1.96−4.00) and 148 (24.2%) patients had high NLR. The composite outcome occurred in 77 (12.6%) older patients, who were more likely to have a high NLR (39.0% versus 22.1%; p = 0.001) than those without a composite outcome. In multivariate logistic regression, high NLR (adjusted odds ratio 2.00; 95% confidence interval 1.07−3.75; p = 0.031) was independently associated with the composite outcome in older patients.ConclusionIn older (aged ≥60 years) patients with acute minor stroke or TIA, a higher NLR, a marker of systemic inflammation that can be easily obtained in routine blood tests, is an independent predictor of subsequent cardiovascular events.
Influence of Early Enteral Nutrition on Clinical Outcomes in Neurocritical Care Patients With Intracerebral Hemorrhage
Authors: Peng Jianhua , Volbers Bastian , Sprügel Maximilian I. , Hoelter Philip , Engelhorn Tobias , Jiang Yong , Kuramatsu Joji B. , Huttner Hagen B. , Dörfler Arnd , Schwab Stefan , Gerner Stefan T. 
Published: April 2021

Objective: Early enteral nutrition (EEN) represents the current standard of care for patients treated in general intensive care units (ICU). Specific nutritional recommendations for patients receiving dedicated neurocritical care are not established. This study investigated associations of EEN with clinical outcomes for patients suffering from intracerebral hemorrhage treated at a neurological ICU (NICU).Methods: This retrospective cohort study included patients admitted to the NICU with atraumatic ICH over a 4-year period. Nutritional data, demographic, clinical, radiological, and laboratory characteristics were assessed. EEN was defined as any enteral nutrition within 48 hours after admission. Comparisons were undertaken for patients with EEN vs. those without, further propensity score (PS) matching (caliper 0.2; one: many) was used to account for baseline imbalances. Primary outcome was the modified Rankin Scale (0–3 = favorable, 4–6 = unfavorable) at 12 months, secondary outcomes comprised perihemorrhagic edema (PHE) volume, infectious complications during the hospital stay, and mRS at 3 months, as well as mortality rates at 3 and 12 months.Results: Of 166 ICH-patients treated at the NICU, 51 (30.7%) patients received EEN, and 115 (69.3%) patients received no EEN (nEEN). After propensity score matching, calories delivered from enteral nutrition (EEN 161.4 [106.4–192.3] kcal/day vs. nEEN 0.0 [0.0–0.0], P &lt; 0.001) and the total calories (EEN 190.0 [126.0–357.0] kcal/day vs. nEEN 33.6 [0.0–190.0] kcal/day, P &lt; 0.001) were significantly different during the first 48 h admitted in NICU. Functional outcome at 12 months (mRS 4–6, EEN 33/43 [76.7%] vs. nEEN, 49/64 [76. 6%]; P = 1.00) was similar in the two groups. There were neither differences in mRS at 3 months, nor in mortality rates at 3 and 12 months between the two groups. EEN did not affect incidence of infective complications or gastrointestinal adverse events during the hospital stay; however, EEN was associated with significantly less extent of PHE evolution [maximum absolute PHE (OR 0.822, 95% CI 0.706–0.957, P = 0.012); maximum relative PHE (OR 0.784, 95% CI 0.646–0.952, P = 0.014)].Conclusion: In our study, EEN was associated with reduced PHE in ICH-patients treated at a NICU. However, this observation did not translate into improved survival or functional outcome at 3 and 12 months.