bluuebunny/crossref_metadata_2025_split huggingface dataset:
Setting the Scope for a New Agile Assessment Model: Results of an Empirical Study
Authors: Tuncel Doruk , Körner Christian , Plösch Reinhold 
Published: June 2021

AbstractAgile software development methods have been increasingly adopted by many organizations at different organizational levels. Whether named agile adoption, agile transition, agile transformation, digital transformation or new ways of working, the success of embracing this change process mostly remains uncertain. This is primarily because there are many ways of evaluating success. Based on the existing agile assessment models, we developed a model of principles with associated practice clusters that serves as a core for a new agile assessment model that is capable of assessing agile organizations at different scale. Towards our ultimate goal to establish a lightweight, context-sensitive agile maturity model, we validated our initial findings in an expert interview study to identify improvement points, and ensure the at hand model’s applicability, coherence and relevance. The results of the interview study show that the structure as well as the content of our assessment model fits with the experts’ expectations and experience.
A Differentially Private Hybrid Approach to Traffic Monitoring
Authors: Rocha Rogério V. M. , Libório Pedro P. , Kupwade Patil Harsh , Aranha Diego F. 
Published: June 2021

AbstractIn recent years, privacy research has been gaining ground in vehicular communication technologies. Collecting data from connected vehicles presents a range of opportunities for industry and government to perform data analytics. Although many researchers have explored some privacy solutions for vehicular communications, the conditions to deploy them are still maturing, especially when it comes to privacy for sensitive data aggregation analysis. In this work, we propose a hybrid solution combining the original differential privacy framework with an instance-based additive noise technique. The results show that for typical instances we obtain a significant reduction in outliers. As far as we know, our paper is the first detailed experimental evaluation of differentially private techniques applied to traffic monitoring. The validation of the proposed solution was performed through extensive simulations in typical traffic scenarios using real data.
Searching for Z′ bosons at the P2 experiment
Authors: Dev P. S. Bhupal , Rodejohann Werner , Xu Xun-Jie , Zhang Yongchao 
Published: June 2021

Abstract
The P2 experiment aims at high-precision measurements of the parity-violating asymmetry in elastic electron-proton and electron-12C scatterings with longitudinally polarized electrons. We discuss here the sensitivity of P2 to new physics mediated by an additional neutral gauge boson Z′ of a new U(1)′ gauge symmetry. If the charge assignment of the U(1)′ is chiral, i.e., left- and right-handed fermions have different charges under U(1)′, additional parity-violation is induced directly. On the other hand, if the U(1)′ has a non-chiral charge assignment, additional parity-violation can be induced via mass or kinetic Z-Z′ mixing. By comparing the P2 sensitivity to existing constraints, we show that in both cases P2 has discovery potential over a wide range of Z′ mass. In particular, for chiral models, the P2 experiment can probe gauge couplings at the order of 10−5 when the Z′ boson is light, and heavy Z′ bosons up to 79 (90) TeV in the proton (12C) mode. For non-chiral models with mass mixing, the P2 experiment is sensitive to mass mixing angles smaller than roughly 10−4, depending on model details and gauge coupling magnitude.
Gauged double field theory as an L∞ algebra
Authors: Lescano Eric , Mayo Martín 
Published: June 2021

Abstract
L∞ algebras describe the underlying algebraic structure of many consistent classical field theories. In this work we analyze the algebraic structure of Gauged Double Field Theory in the generalized flux formalism. The symmetry transformations consist of a generalized deformed Lie derivative and double Lorentz transformations. We obtain all the non-trivial products in a closed form considering a generalized Kerr-Schild ansatz for the generalized frame and we include a linear perturbation for the generalized dilaton. The off-shell structure can be cast in an L3 algebra and when one considers dynamics the former is exactly promoted to an L4 algebra. The present computations show the fully algebraic structure of the fundamental charged heterotic string and the $$ {L}_3^{\mathrm{gauge}} $$

L
3
gauge

structure of (Bosonic) Enhanced Double Field Theory.
Fast and sensitive method for phosphorus determination in dairy products
Authors: Gliszczyńska-Świgło Anna , Rybicka Iga 
Published: June 2021

AbstractThe spectrophotometric molybdenum blue method for phosphorus determination was adapted to a multiwell plate format. The method was sensitive and allowed for the simultaneous determination of phosphorus in many samples. It was cheap and eco-friendly due to application of small volumes of reagents and, therefore, it meets the requirements for “green” or sustainable chemistry. The method’s limit of detection (LOD) is 0.37 μg/mL and its limit of quantification (LOQ) is 1.13 μg/mL. Its linearity is up to 30 μg of phosphorus/mL. The method was applied for the determination of phosphorus in 65 dairy products (yogurts, yogurt drinks, buttermilks, kefirs and homogenized cheeses) of strawberry, peach, forest fruits, vanilla and other flavours. The phosphorus content was 143–226 mg/100 g in flavoured yogurts, 78–204 mg/100 g in yogurt drinks, 89–218 mg/100 g in kefirs, around 195 mg/100 g in buttermilks, and 165–277 mg/100 g in homogenized cheeses. The presented method can be used in the routine quantitative analysis of the total phosphorus content in dairy products.
Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD
Authors: Toschi Chiara , Hervig Mona El-Sayed , Moazen Parisa , Parker Maximilian G. , Dalley Jeffrey W. , Gether Ulrik , Robbins Trevor W. 
Published: June 2021

Abstract
Background
Work in humans has shown that impulsivity can be advantageous in certain settings. However, evidence for so-called functional impulsivity is lacking in experimental animals.

Aims
This study investigated the contexts in which high impulsive (HI) rats show an advantage in performance compared with mid- (MI) and low impulsive (LI) rats. We also assessed the effects of dopaminergic and noradrenergic agents to investigate underlying neurotransmitter mechanisms.

Methods
We tested rats on a variable inter-trial interval (ITI) version of the 5-choice serial reaction time task (5CSRTT). Rats received systemic injections of methylphenidate (MPH, 1 mg/kg and 3 mg/kg), atomoxetine (ATO, 0.3 mg/kg and 1 mg/kg), amphetamine (AMPH, 0.2 mg/kg), the alpha-2a adrenoceptor antagonist atipamezole (ATI, 0.3 mg/kg) and the alpha-1 adrenoceptor agonist phenylephrine (PHEN, 1 mg/kg) prior to behavioural testing.

Results
Unlike LI rats, HI rats exhibited superior performance, earning more reinforcers, on short ITI trials, when the task required rapid responding. MPH, AMPH and ATI improved performance on short ITI trials and increased impulsivity in long ITI trials, recapitulating the behavioural profile of HI. In contrast, ATO and PHEN impaired performance on short ITI trials and decreased impulsivity, thus mimicking the behavioural profile of LI rats. The effects of ATO were greater on MI rats and LI rats.

Conclusions
These findings indicate that impulsivity can be advantageous when rapid focusing and actions are required, an effect that may depend on increased dopamine neurotransmission. Conversely, activation of the noradrenergic system, with ATO and PHEN, led to a general inhibition of responding.
SPINE20 A global advocacy group promoting evidence-based spine care of value
Authors: AlEissa Sami I. , Tamai Koji , Konbaz Faisal , Alturkistany Ahmed , Blattert Thomas R. , Chhabra Harvinder S. , Costanzo Giuseppe , Dohring Edward J. , Kandziora Frank , Kothe Ralph , Misaggi Bernardo , Muehlbauer Eric J. , Pereira Paulo , Rajasekaran Shanmuganathan , Sullivan William J. , Truumees Eeric , Alqahtani Yahya , Alsobayel Hana I. , Franke Joerg , Teli Marco G. A. , Wang Jeffrey C. , Al-Hazzaa Hazzaa M. , Alosaimi Majed Nasser , Berven Sigurd , Brayda-Bruno Marco , Briggs Andrew M. , Busari Jamiu O. , Caserta Antonello-Valerio , Côté Pierre , Crostelli Marco , Fehlings Michael G. , Gunzburg Robert , Haddadin Sami , Ihm Joseph , Hilibrand Alan S. , Luca Andrea , Osvaldo Mazza , Pigott Tim , Rothenfluh Dominique A. , Ruosi Carlo , Salmi Louis-Rachid , Shetty Ajoy P. , Singh Kern , Vaccaro Alexander R. , Wong David A. , Zileli Mehmet , Nordin Margareta 
Published: June 2021

Abstract
Purpose
The Global Burden of Diseases (GBD) Studies have estimated that low back pain is one of the costliest ailments worldwide. Subsequent to GBD publications, leadership of the four largest global spine societies agreed to form SPINE20. This article introduces the concept of SPINE20, the recommendations, and the future of this global advocacy group linked to G20 annual summits.

Methods
The founders of SPINE20 advocacy group coordinated with G20 Saudi Arabia to conduct the SPINE20 summit in 2020. The summit was intended to promote evidence-based recommendations to use the most reliable information from high-level research. Eight areas of importance to mitigate spine disorders were identified through a voting process of the participating societies. Twelve recommendations were discussed and vetted.

Results
The areas of immediate concern were “Aging spine,” “Future of spine care,” “Spinal cord injuries,” “Children and adolescent spine,” “Spine-related disability,” “Spine Educational Standards,” “Patient safety,” and “Burden on economy.” Twelve recommendations were created and endorsed by 31/33 spine societies and 2 journals globally during a vetted process through the SPINE20.org website and during the virtual inaugural meeting November 10–11, 2020 held from the G20 platform.

Conclusions
This is the first time that international spine societies have joined to support actions to mitigate the burden of spine disorders across the globe. SPINE20 seeks to change awareness and treatment of spine pain by supporting local projects that implement value-based practices with healthcare policies that are culturally sensitive based on scientific evidence.
Free amino acid contents of selected Ethiopian plant and fungi species: a search for alternative natural free amino acid sources for cosmeceutical applications
Authors: Kahsay Birhanu Nigusse , Ziegler Jörg , Imming Peter , Gebre-Mariam Tsige , Neubert Reinhard H. H. , Moeller Lucie 
Published: June 2021

AbstractFree amino acids (FAAs), the major constituents of the natural moisturizing factor (NMF), are very important for maintaining the moisture balance of human skin and their deficiency results in dry skin conditions. There is a great interest in the identification and use of nature-based sources of these molecules for such cosmeceutical applications. The objective of the present study was, therefore, to investigate the FAA contents of selected Ethiopian plant and fungi species; and select the best sources so as to use them for the stated purpose. About 59 different plant species and oyster mushroom were included in the study and the concentrations of 27 FAAs were analyzed. Each sample was collected, lyophilized, extracted using aqueous solvent, derivatized with Fluorenylmethoxycarbonyl chloride (Fmoc-Cl) prior to solid-phase extraction and quantified using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometric (LC-ESI–MS/MS) system. All the 27 FAAs were detected in most of the samples. The dominant FAAs that are part of the NMF were found at sufficiently high concentration in the mushroom and some of the plants. This indicates that FAAs that could be included in the preparations for the management of dry skin condition can be obtained from a single natural resource and the use of these resources for the specified purpose have both economic and therapeutic advantage in addition to fulfilling customer needs.
Pivotal Response Treatment with and without robot-assistance for children with autism: a randomized controlled trial
Authors: van den Berk-Smeekens Iris , de Korte Manon W. P. , van Dongen-Boomsma Martine , Oosterling Iris J. , den Boer Jenny C. , Barakova Emilia I. , Lourens Tino , Glennon Jeffrey C. , Staal Wouter G. , Buitelaar Jan K. 
Published: June 2021

AbstractPivotal response treatment (PRT) is a promising intervention focused on improving social communication skills in children with autism spectrum disorder (ASD). Since robots potentially appeal to children with ASD and may contribute to their motivation for social interaction, this exploratory randomized controlled trial (RCT) was conducted comparing PRT (PRT and robot-assisted PRT) with treatment-as-usual (TAU). Seventy-three children (PRT: n = 25; PRT + robot: n = 25; TAU: n = 23) with ASD, aged 3–8 years were assessed at baseline, after 10 and 20 weeks of intervention, and at 3-month follow-up. There were no significant group differences on parent- and teacher-rated general social-communicative skills and blindly rated global functioning directly after treatment. However, at follow-up largest gains were observed in robot-assisted PRT compared to other groups. These results suggest that robot-assistance may contribute to intervention efficacy for children with ASD when using game scenarios for robot-child interaction during multiple sessions combined with motivational components of PRT. This trial is registered at https://www.trialregister.nl/trial/4487; NL4487/NTR4712 (2014-08-01).
Value-based pricing for advanced therapy medicinal products: emerging affordability solutions
Authors: Gonçalves Elisabete 
Published: June 2021

AbstractThe emergence of advanced therapy medicinal products (ATMPs), a disruptive class of health technologies, is generating important challenges in terms of value assessment and their high prices introduce critical access and affordability concerns. The aim of this article is to analyze the challenges of traditional value assessment and price and reimbursement methods in the evaluation of ATMPs and to characterize the current and prospective financing solutions that may ensure patient access and affordability for these health technologies. Standard Health Technology Assessment (HTA) is not designed for ATMPs, and may delay access to these health technologies, thus a broader concept of value is required. As a consequence, value-based pricing methodologies have been gaining terrain to cope with the specific challenges of ATMPs. The pricing and reimbursement framework should ensure the balance between encouragements to innovation and maximization of value for money for payers, through the attribution of a fair price to new health technologies. Early scientific advice by regulatory and HTA bodies to developers is key, as it will contribute to diminish the perspective gap between developers, regulators and payers. The high efficacy/high price dynamic of many advanced therapies will demand novel financing models, both in the EU and US. Managed entry agreements (MEA), with financing being conditional to the submission of additional evidence, associated with methods of leased payments, may offer effective strategies to address the uncertainties caused by the evidence gap associated with ATMPs, ensuring affordable and sustained access.
Auf welcher Seite des Baumes können Reflexionsfolien die Fruchtfarbe stärker verbessern?
Authors: Hess Patrick , Blanke Michael 
Published: June 2021

ZusammenfassungIm Rahmen einer Masterarbeit sollte untersucht werden, wie weit und von welcher Seite des Baumes bzw. Baumreihe Reflexionsfolien aus Kunststoff (in der Fahrgasse) und recyceltem Aluminium (direkt unter den Bäumen) zur Verbesserung der Fruchtfarbe im Herbst beitragen.Aus früheren Arbeiten war bekannt, dass die Lichtstrahlung durch Gewebefolien weit in die Baumkrone reflektiert wird, aber nicht, ob diese Lichtstärke ausreicht, die Äpfel in verschiedenen Regionen der Baumkrone besser zu färben und ob Aluminiumfolie die gleiche Wirkung zeigt.Daher wurden 90 neun Jahre alte Apfelbäume der Sorte ‘Braeburn, Hillwell‘ auf M 9 unter grauem Hagelnetz auf dem Campus Klein-Altendorf der Universität Bonn im September 2018 – einem Jahr mit guter Fruchtausfärbung – untersucht. Die Apfelbäume waren als schlanke Spindel erzogen und die Reihen zur Optimierung der Lichtnutzung in N‑S-Ausrichtung gepflanzt. Die Gewebefolie Lumilys mit 2,6 m Breite wurde in den Fahrgassen und eine Folie aus 80 % recyceltem Aluminium 2 × 60 cm breit direkt unter den Bäumen ca. 6 Wochen vor dem geschätzten Erntetermin ausgelegt. Als chemische Variante wurden Bäume mit dem Biostimulanz StimplexTM mit 2 × 4 l/ha nach Herstellerempfehlung behandelt; Bäume der gleichen Reihen ohne Behandlung dienten als Kontrolle. Ab 6 Wochen vor der Ernte wurden 3600 Farbwinkelmessungen an den gleichen 180 Apfelfrüchten am Baum durchgeführt mit folgenden Ergebnissen

Die schlechtere Rotfärbung der Apfelfrüchte auf der Ostseite (Kontrolle ca. 69°hue) als auf der Westseite (ca. 51°hue) kann eine Farbverbesserung auf der Ostseite des Baumes durch Folien, Chemikalien oder andere Mittel erfordern.

Auf dieser schlecht belichteten Ostseite zeigten die Apfelfrüchte im unteren Kronenbereich unter 1 m Kronenhöhe die schlechteste Rotfärbung – mit 66,4°hue bei Stimplex, 69,1°hue in der Kontrolle und 70,4°hue bei Folienwechsel.

Auf dieser schlecht belichteten Ostseite unter 1 m Kronenhöhe zeigten die Reflexionsfolien die stärkste Wirkung – mit guter Rotfärbung der Apfelfrüchte direkt über der Aluminiumfolie (53,3°hue) und sowohl über der Gewebefolie Lumilys in jeder (59,6°hue) als auch jeder 2. Reihe (57°hue).

Auf der gut belichteten Westseite im Kronenbereich über 1 m zeigten die Reflexionsfolien dagegen eine geringe Wirkung; nur in diesem Bereich verbesserten weder die Aluminium- noch die Textilfolie Lumilys die Rotfärbung.

Das Auslegen der Gewebefolie Lumilys in jeder 2. Reihe bzw. Fahrgasse erzielte eine gleich gute Verbesserung der Rotfärbung wie das Auslegen in jeder Reihe und die (recycelte) Aluminiumfolie direkt unter den Bäumen.
Generell wirkten die Reflexionsfolien – unabhängig von Material und Auslegen – auf die Fruchtausfärbung in diesem Jahr 2018 am besten an den stärker beschatteten Stellen in der Baumkrone.
Repeated talaporfin sodium photodynamic therapy for esophageal cancer: safety and efficacy
Authors: Tamaoki Masashi , Yokoyama Akira , Horimatsu Takahiro , Hirohashi Kenshiro , Amanuma Yusuke , Higuchi Hirokazu , Mitani Yosuke , Yoshioka Masahiro , Ohashi Shinya , Muto Manabu 
Published: June 2021

Abstract
Background
Talaporfin sodium photodynamic therapy (tPDT) is an effective salvage treatment for local failure after chemoradiotherapy for esophageal cancer. Repeated tPDT could also be indicated for local recurrence or residue after the first salvage tPDT. However, the safety and efficacy of repeated tPDT have not been elucidated.

Methods
We reviewed 52 patients with esophageal cancer who were treated with the first tPDT at Kyoto University Hospital between October 2015 and April 2020.

Results
Among 52 patients, repeated tPDT after the first tPDT was indicated for 13 patients (25%), of which six had residual tumor, four had local recurrence after complete response (CR) after the first tPDT at the primary site, and six had metachronous lesion. The total session of repeated tPDT was 25; 16 were for primary sites and nine were for metachronous sites. Among them, six patients (46.2%) achieved local (L)-CR and nine lesions (56.3%) achieved lesion L-CR. By session, 10 sessions (40%) achieved L-CR. There were no severe adverse events except for one patient; this patient showed grade 3 esophageal stenosis and perforation after the third tPDT on the same lesion that was previously treated with porfimer sodium photodynamic therapy four times.

Conclusion
Repeated tPDT could be an effective and safe treatment for local failure even after salvage tPDT for esophageal cancer.
Therapeutic Properties of Highly Selective β-blockers With or Without Additional Vasodilator Properties: Focus on Bisoprolol and Nebivolol in Patients With Cardiovascular Disease
Authors: AlHabeeb Waleed , Mrabeti Sanaa , Abdelsalam Ahmed Adel Ibrahim 
Published: June 2021

AbstractBisoprolol and nebivolol are highly selective β1-adrenoceptor antagonists, with clinical indications in many countries within the management of heart failure with reduced left ventricular ejection fraction (HFrEF), ischaemic heart disease (IHD), and hypertension. Nebivolol has additional vasodilator actions, related to enhanced release of NO in the vascular wall. In principle, this additional mechanism compared with bisoprolol might lead to more potent vasodilatation, which in turn might influence the effectiveness of nebivolol in the management of HFrEF, IHD and hypertension. In this article, we review the therapeutic properties of bisoprolol and nebivolol, as representatives of “second generation” and “third generation” β-blockers, respectively. Although head-to-head trials are largely lacking, there is no clear indication from published studies of an additional effect of nebivolol on clinical outcomes in patients with HFrEF or the magnitude of reductions of BP in patients with hypertension.
Data challenges for future plant gene editing: expert opinion
Authors: Lassoued Rim , Macall Diego M. , Smyth Stuart J. , Phillips Peter W. B. , Hesseln Hayley 
Published: June 2021

AbstractAgricultural data in its multiple forms are ubiquitous. With progress in crop and input monitoring systems and price reductions over the past decade, data are now being captured at an unprecedented rate. Once compiled, organized and analyzed, these data are capable of providing valuable insights into much of the agri-food supply chain. While much of the focus is on precision farming, agricultural data applications coupled with gene editing tools hold the potential to enhance crop performance and global food security. Yet, digitization of agriculture is a double-edged sword as it comes with inherent security and privacy quandaries. Infrastructure, policies, and practices to better harness the value of data are still lacking. This article reports expert opinions about the potential challenges regarding the use of data relevant to the development and approval of new crop traits as well as mechanisms employed to manage and protect data. While data could be of great value, issues of intellectual property and accessibility surround many of its forms. The key finding of this research is that surveyed experts optimistically report that by 2030, the synergy of computing power and genome editing could have profound effects on the global agri-food system, but that the European Union may not participate fully in this transformation.