bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Aspects of Anthracycline Cardiotoxicity
Authors: Russo Michele , Della Sala Angela , Tocchetti Carlo Gabriele , Porporato Paolo Ettore , Ghigo Alessandra 
Published: February 2021

Opinion statementHeart failure (HF) is increasingly recognized as the major complication of chemotherapy regimens. Despite the development of modern targeted therapies such as monoclonal antibodies, doxorubicin (DOXO), one of the most cardiotoxic anticancer agents, still remains the treatment of choice for several solid and hematological tumors. The insurgence of cardiotoxicity represents the major limitation to the clinical use of this potent anticancer drug. At the molecular level, cardiac side effects of DOXO have been associated to mitochondrial dysfunction, DNA damage, impairment of iron metabolism, apoptosis, and autophagy dysregulation. On these bases, the antioxidant and iron chelator molecule, dexrazoxane, currently represents the unique FDA-approved cardioprotectant for patients treated with anthracyclines.A less explored area of research concerns the impact of DOXO on cardiac metabolism. Recent metabolomic studies highlight the possibility that cardiac metabolic alterations may critically contribute to the development of DOXO cardiotoxicity. Among these, the impairment of oxidative phosphorylation and the persistent activation of glycolysis, which are commonly observed in response to DOXO treatment, may undermine the ability of cardiomyocytes to meet the energy demand, eventually leading to energetic failure. Moreover, increasing evidence links DOXO cardiotoxicity to imbalanced insulin signaling and to cardiac insulin resistance. Although anti-diabetic drugs, such as empagliflozin and metformin, have shown interesting cardioprotective effects in vitro and in vivo in different models of heart failure, their mechanism of action is unclear, and their use for the treatment of DOXO cardiotoxicity is still unexplored.This review article aims at summarizing current evidence of the metabolic derangements induced by DOXO and at providing speculations on how key players of cardiac metabolism could be pharmacologically targeted to prevent or cure DOXO cardiomyopathy.
Truss-type maintenance devices and corresponding pipeline lifting control strategies
Authors: Zhao Tian-Feng , Zhang Qing-Yuan , Chu Gui 
Published: February 2021

AbstractFor new submarine pipeline maintenance lifting equipment, a specialized analysis model is constructed in this study. A pipeline can be divided into the lifted portion and the touch-down portion that lies on the seabed, and each of these portions can be analyzed separately by converting the continuity conditions at the touch-down points to boundary conditions. The typical two-point sequence secant iterative technique is used to obtain the unknown lifted length and determine pipeline lifting configurations. The BVP4C module in MATLAB software is used to solve this multiple-point boundary value problem issued from first-order differential equations. Also, the triple-point lifting mode of truncated maintenance and the two-point lifting mode of online maintenance are discussed. When the lifted heights at truss positions are shown, the lifting deformation, lifting forces, bending moment distribution, and axial force distribution can be analyzed using a dedicated analysis program. Numerical results can then be used to design a lifting strategy to protect the pipeline.
Two Kinds of Imaginative Vividness
Authors: Langkau Julia 
Published: February 2021

AbstractThis paper argues that we should distinguish two different kinds of imaginative vividness: vividness of mental images and vividness of imaginative experiences. Philosophy has focussed on mental images, but distinguishing more complex vivid imaginative experiences from vivid mental images can help us understand our intuitions concerning the notion as well as the explanatory power of vividness. In particular, it can help us understand the epistemic role imagination can play on the one hand and our emotional engagement with literary fiction on the other hand.
Teaching I-O psychology to undergraduate students: Do we practice what we preach?
Authors: Kath Lisa M. , Salter Nicholas P. , Bachiochi Peter , Brown Kenneth G. , Hebl Mikki 
Published: February 2021

AbstractAs industrial-organizational (I-O) psychologists, we have expertise in applying psychological and/or organizational science to the workplace. However, many of us haven’t taken the time to think about how our I-O psychology knowledge can apply to our teaching practice. We walk through some examples of how I-O psychology research can help us be better teachers, and the goal of our paper is to encourage readers to make evidence-based changes to their teaching based on I-O psychology research. We organize our discussion around four areas: training and development, diversity and inclusion, groups and teams, and leadership. Within each, we offer small, medium, and large changes that could be incorporated into classrooms. We hope that readers will be inspired to build on what they do in their classrooms to help students learn about (and be inspired by) our field.
Association betweenSalmonellainfection and colon cancer: a nationwide registry-based cohort study
Authors: Duijster Janneke W. , Hansen Jørgen V. , Franz Eelco , Neefjes Jacques J. C. , Frisch Morten , Mughini-Gras Lapo , Ethelberg Steen 
Published: February 2021

AbstractLaboratory data increasingly suggest thatSalmonellainfection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population. We conducted a population-based cohort study using four health registries in Denmark. Person-level demographic data of all residents were linked to laboratory-confirmed non-typhoidal salmonellosis and to CC diagnoses in 1994–2016. Hazard ratios (HRs) for CC (overall/proximal/distal) associated with reported salmonellosis were estimated using Cox proportional hazard models. Potential effects of serovar, age, sex, inflammatory bowel disease and follow-up time post-infection were also assessed. We found no increased risk of CC ≥1 year post-infection (HR 0.99; 95% confidence interval (CI) 0.88–1.13). When stratifying by serovar, there was a significantly increased risk of proximal CC ≥1 year post-infection with serovars other than Enteritidis and Typhimurium (HR 1.40; 95% CI 1.03–1.90). CC risk was significantly increased in the first year post-infection (HR 2.08; 95% CI 1.48–2.93). The association between salmonellosis and CC in the first year post-infection can be explained by increased stool testing around the time of CC diagnosis. The association between proximal CC and non-Enteritidis/non-Typhimurium serovars is unclear and warrants further investigation. Overall, this study provides epidemiological evidence that notifiedSalmonellainfections do not contribute significantly to CC risk in the studied population.
Analysing how changes in the health status of healthcare workers affects epidemic outcomes
Authors: Phadke I. , McKee A. , Conway J.M. , Shea K. 
Published: February 2021

Abstract
During a disease outbreak, healthcare workers (HCWs) are essential to treat infected individuals. However, these HCWs are themselves susceptible to contracting the disease. As more HCWs get infected, fewer are available to provide care for others, and the overall quality of care available to infected individuals declines. This depletion of HCWs may contribute to the epidemic's severity. To examine this issue, we explicitly model declining quality of care in four differential equation-based susceptible, infected and recovered-type models with vaccination. We assume that vaccination, recovery and survival rates are affected by quality of care delivered. We show that explicitly modelling HCWs and accounting for declining quality of care significantly alters model-predicted disease outcomes, specifically case counts and mortality. Models neglecting the decline of quality of care resulting from infection of HCWs may significantly under-estimate cases and mortality. These models may be useful to inform health policy that may differ for HCWs and the general population. Models accounting for declining quality of care may therefore improve the management interventions considered to mitigate the effects of a future outbreak.
Zigler's conceptualization of diversity: Implications for the early childhood development workforce
Authors: García Coll Cynthia , Ferrer Kia L. 
Published: February 2021

AbstractThe United States is entering a pivotal period in history, led by extraordinary shifts in the demographic makeup of children who are in need of medical, educational, and developmental services. For the first time in this country's history, the majority of children are being born to non-white populations. Simultaneously, racism (personal, institutional, and systemic) is now being recognized as a powerful social determinant of children's mental and physical health by the time they enter kindergarten. It is crucial to evaluate how early childhood development (ECD) settings are prepared to authentically engage racially diverse children. In this paper, we critically analyze the narratives of the architect of Head Start, Dr. Edward Zigler, and investigate his evolving contributions to early childhood programming. We propose that Zigler's conceptualization of culture and its impact on children's development, although advanced for his time, had historical limitations that have perpetuated the personal, institutional, and systemic racism that children of color experience in early childhood settings. This paper concludes with suggestions to include topics covering implicit bias, white privilege, and the impact of slavery, colonization, and oppression as core principles in professional training. Only then will we be able to eliminate racism across early childhood settings in the United States.
Recovery priorities of people with psychosis in acute mental health in-patient settings: a Q-methodology study
Authors: Douglas Catherine , Wood Lisa , Taggart Danny 
Published: February 2021

AbstractBackground:Personal recovery from psychosis has been explored extensively in community samples but there has been little exploration with people currently receiving care from an acute mental health in-patient setting.Aims:The aim of this study was to explore the personal recovery priorities of people experiencing psychosis who are currently receiving care from an acute mental health in-patient ward.Method:A Q-methodology mixed-methods approach was adopted. Thirty-eight participants were recruited from an outer London acute mental health hospital. They were required to sort 54 statements regarding personal recovery from most important to least important to reflect their recovery priorities. Thirty-six were included in the final analysis.Results:Analysis revealed four distinct viewpoints relating to factors that promote recovery in the acute mental health in-patient setting. These were: stability, independence and ‘keeping a roof over your head’; hope, optimism and enhancing well-being; personal change, self-management and social support; and symptom reduction through mental health support.Conclusions:Acute mental health in-patient wards need to ensure that they are considering the personal recovery needs of in-patients. Symptom reduction was valued by some, but broad psychosocial factors were also of priority.
Expanding health care coverage in Canada: a dramatic shift in the debate
Authors: Marchildon Gregory P. , Tuohy Carolyn H. 
Published: February 2021

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has shifted the health policy debate in Canada. While the pre-pandemic focus of policy experts and government reports was on the question of whether to add outpatient pharmaceuticals to universal health coverage, the clustering of pandemic deaths in long-term care facilities has spurred calls for federal standards in long-term care (LTC) and its possible inclusion in universal health coverage. This has led to the probability that the federal government will attempt to expand medicare as Canadians have known it for the first time in over a half century. However, these efforts are likely to fail if the federal government relies on the shared-cost federalism that marked the earlier introduction of medicare. Two alternative pathways are suggested, one for LTC and one for pharmaceuticals, that are more likely to succeed given the state of the Canadian federation in the early 21st century.
Review of the Precise Orbit Determination for Chinese Lunar Exploration Projects
Authors: Liu Shanhong , Yan Jianguo , Cao Jianfeng , Ye Mao , Li Xie , Li Fei , Barriot Jean‐Pierre 
Published: February 2021

AbstractChina's lunar exploration program has developed and progressed for more than 13 years. Over this time, Precise Orbit Determination (POD) has guaranteed successful execution of the Chang’e missions, and is the basis for further scientific investigations using radio science data; for example, recovering the lunar gravity field to explore the inner structure and detect craters to study the evolutionary history of the moon. This study briefly reviews the Chang’e series mission orbit and radio tracking measurements. We reprocessed the tracking data and comprehensively summarized the evolution of the POD accuracy and the tracking system precision from the Chang’e 1 to Chang’e 4 missions using in‐house software. Our results show a progression of the tracking station, as the first Chang’e 1 mission only reached several millimeters per second level accuracy in the Doppler measurements and several meters level accuracy for the two‐way range measurements. Later on the accuracy of Chang’e 5T1 Doppler measurements reached about 0.35 mm/s and the accuracy of the Chang’e 3 two‐way range measurements below 0.7 m. Moreover, the newest Chang’e 4 relay satellite achieved POD residuals Root Mean Square for the two‐way range less than a meter and orbital accuracy at 200 m level, in contrast to meters level residual and the half‐kilometer level accuracy achieved during the Chang’e 1 mission. We can clearly see that the POD performance of the Chang’e spacecraft continuously improved. This research study is a reference for future Chinese Lunar exploration missions, as well as Chinese Mars and asteroid explorations.
Crust and Upper Mantle Structure of the South China Sea and Adjacent Areas From the Joint Inversion of Ambient Noise and Earthquake Surface Wave Dispersions
Authors: Chen Haopeng , Li Zhiwei , Luo Zhicai , Ojo Adebayo Oluwaseun , Xie Jun , Bao Feng , Wang Liaoliang , Tu Guanghong 
Published: February 2021

AbstractIn this study, we built a high‐resolution 3D S‐wave velocity model of the South China Sea (SCS) and adjacent areas by the joint inversion of surface wave dispersions retrieved from ambient noise and earthquake data. We first measured Rayleigh wave phase velocity dispersions from the waveforms recorded by 94 broadband seismic stations. Subsequently, we used a generalized least squares inversion scheme with spatially varying resolution to perform 2D tomographic inversion at different periods. Lastly, we performed 1D inversion at different grid points and obtained the 3D S‐wave velocity model in the depth range of 15–250 km. Our model reveals a prominent high velocity (high‐V) anomaly beneath the SCS basin and shows that the lithosphere beneath the SCS basin is about 70–80 km thick. We observe a prominent low velocity (low‐V) anomaly in the asthenosphere beneath the SCS basin, and we interpret this as evidence for the ongoing partial melting of the asthenosphere. An obvious high‐V anomaly is also revealed beneath the Khorat Plateau (KP) in the depth range of 80–150 km, suggesting that the KP has a cold and thick lithosphere and has suffered limited destruction in the Cenozoic era. In the northern part of Kalimantan Island (KI), a prominent low‐V anomaly is shown in the upper 60 km of the lithosphere revealing the upwelling of the asthenosphere. Our findings shed lights on the tectonic evolution of the SCS and adjacent areas.
Sensitive Dependence of Ultrarelativistic Electron Precipitation on EMIC Wave Frequency
Authors: Lee Dae‐Young 
Published: February 2021

AbstractElectromagnetic ion cyclotron (EMIC) waves have long been considered to cause atmospheric precipitation loss of relativistic electrons, the quantitative evaluation of which is critical for understanding the radiation belt electron flux dropouts. In this study, we report test particle calculation results on precipitation loss rates of 5 MeV electrons with initial pitch angles of 4–10° at the equator by He+ band EMIC waves. We find a sensitive dependence of the precipitation loss rates on the wave frequency in that a preferred wave frequency (maximum loss frequency) exists at which the loss rate peaks predominantly and away from which it declines substantially. According to a cold plasma dispersion relation, a small difference in wave frequency just below the He+ gyrofrequency corresponds to a significant difference in wavenumber. Different frequencies lead to phase trapping of different extents, which determines the significance of loss cone scattering at the exit latitude from the wave zone. At frequencies below the maximum loss frequency, phase trapping causes large advective pitch angle changes, prohibiting loss cone scattering. At the maximum loss frequency, the phase‐trapping effect is optimized such that diffusion is dominant over advection and large enough to allow effective loss cone scattering. At frequencies above the maximum loss frequency, the phase‐trapping effect disappears, and the resulting (both diffusive and advective) scattering is too weak to drive loss cone scattering unless the initial pitch angle is close enough to the loss cone angle.
Two Years of Observations of the Io Plasma Torus by Juno Radio Occultations: Results From Perijoves 1 to 15
Authors: Phipps Phillip H. , Withers Paul , Buccino Dustin R. , Yang Yu‐Ming , Parisi Marzia 
Published: February 2021

AbstractThe Io plasma torus is the primary source for plasma in Jupiter’s magnetosphere. Observations of fundamental properties of the torus place valuable constraints on how the Io plasma torus behaves. Yet measurements of the density structure of the torus that precisely determine its location, total electron content, and scale height are rare. Here, we report measurements of four profiles of the total electron content through the torus by the Juno spacecraft. These profiles were acquired by radio occultation observations during Juno Perijoves 10, 11, 14, and 15. They complement previously reported profiles from Perijoves 1, 3, 6, and 8, for which an initial ad hoc correction has been verified by improved calibration at the ground station. Fits to each profile determined the location, peak total electron content, and scale height of two torus regions: the cold torus and the torus beyond 5.5 RJ. Measurements show the torus locations depend on longitude, but not time. The peak total electron content values vary with time but do not exhibit any clear dependence on longitude. The scale heights may depend on longitude and/or time. There is no apparent dependence of these properties on the Io phase angle. Future analysis of more observations by the Juno spacecraft will clarify the respective roles of longitude, time, and the Io phase angle in shaping the density structure of the Io plasma torus. Observations at previously sampled longitudes will be particularly valuable, as demonstrated here by Perijoves 8 and 15, which sampled the same longitude 1 year apart.
A High‐Resolution Paleosecular Variation Record for Marine Isotope Stage 6 From Southeastern Black Sea Sediments
Authors: Nowaczyk Norbert R. , Liu Jiabo , Plessen Birgit , Wegwerth Antje , Arz Helge W. 
Published: February 2021

AbstractA full‐vector paleosecular variation (PSV) record (inclination, declination, and relative paleointensity) from the pen‐ultimate glacial (130–180 ka) could be constructed from a total of 12 sediment cores recovered from the Arkhangelsky Ridge in the SE Black Sea. Stacking of the individual partly fragmented records was achieved by a detailed correlation using high‐resolution data records from X‐ray fluorescence scanning, Ca/Ti and K/Ti log‐ratios, as well as magnetic susceptibility. Age constraints are provided by a detailed composite oxygen isotope stratigraphy from three of the cores, correlated to U‐Th‐dated speleothem oxygen isotope records from Hungary and Turkey. The temporal resolution of the stacked paleomagnetic data records is 200 years. Practically, this data set is the first high‐resolution PSV record for SE Europe/SW Asia from marine isotope stage 6, comprising inclination, declination and relative paleointensity. Besides an easterly swing in declination at ∼159 ka and a pronounced intensity low together with low inclinations at ∼148 ka, both not reaching an excursional PSV index of >0.5, the obtained directional variations reflect only normal PSVs, with a PSV index of <0.3.
Continuous Dynamics of Dissolved Methane Over 2 Years and its Carbon Isotopes (δ13C, Δ14C) in a Small Arctic Lake in the Mackenzie Delta
Authors: McIntosh Marcek Hadley A. , Lesack Lance F. W. , Orcutt Beth N. , Wheat C. Geoff , Dallimore Scott R. , Geeves Kimberley , Lapham Laura L. 
Published: February 2021

AbstractSeasonally ice‐covered permafrost lakes in the Arctic emit methane to the atmosphere during periods of open‐water. However, processes contributing to methane cycling under‐ice have not been thoroughly addressed despite the potential for significant methane emission to the atmosphere at ice‐out. We studied annual dissolved methane dynamics within a small (0.2 ha) Mackenzie River Delta lake using sensor and water sampling packages that autonomously and continuously collected lake water samples, respectively, for two years at multiple water column depths. Lake physical and biogeochemical properties (temperature; light; concentrations of dissolved oxygen, manganese, iron, and dissolved methane, including stable carbon, and radiocarbon isotopes) revealed annual patterns. Dissolved methane concentrations increase under‐ice after electron acceptors (oxygen, manganese, and iron oxides) are depleted or inaccessible from the water column. The radiocarbon age of dissolved methane suggests a source from recently decomposed carbon as opposed to thawed ancient permafrost. Sources of dissolved methane under‐ice include a diffusive flux from the sediments and may include water column methanogenesis and/or under‐ice hydrodynamic controls. Following ice‐out, the water column only partially mixes allowing half of the winter‐derived dissolved methane to be microbially oxidized. Despite oxidation at depth, surface water was a source of methane to the atmosphere. The greatest diffusive fluxes to the atmosphere occurred following ice‐out (75 mmol CH4 m−2 d−1) and during a mixing episode in mid‐July, likely driven by a storm event. This study demonstrates the importance of fine‐scale temporal sampling to understand dissolved methane processes in seasonally ice‐covered lakes.