bluuebunny/crossref_metadata_2025_split huggingface dataset:
How confident are pharmacists in providing pharmaceutical care on anticoagulants? A cross-sectional, self-administered questionnaire study in Borneo, Malaysia
Authors: Tan Sze Ling , Yong Zai Yang , Liew Jerry Ee Siung , Zainal Hadzliana , Siddiqui Sania 
Published: November 2021

Abstract
Background
Anticoagulants are the cornerstone therapy for the management of venous thromboembolism (VTE) and atrial fibrillation (AF). Pharmacists should be confident and equipped with the skill and updated knowledge in managing anticoagulation therapy.

Objective
To explore self-reported confidence level of pharmacists, perceived reasons influencing their confidence and socio-demographic associated with high confidence level in the area of anticoagulation.

Methods
A cross-sectional, self-administered questionnaire survey was carried out among fully registered pharmacists who work in selected government hospitals and clinics in Borneo, Malaysia, from January 2019 to February 2020.

Results
Overall, responses from 542 fully registered pharmacists were obtained. Proportion of respondents who claimed confident in providing necessary information to patient receiving warfarin (n = 479, 88.3%) was significantly higher (p < 0.001) compared to low molecular weight heparins (n = 317, 58.5%) and direct oral anticoagulants (n = 211, 38.9%). Respondents’ perceived reasons that may influence their confidence level include experience in dealing with anticoagulants’ cases (n = 469, 86.5%), knowledge on anticoagulants (n = 394, 72.7%) and knowledge on diseases needing anticoagulation therapy (n = 311, 57.4%). Practising as ward pharmacist and “always” dealing with anticoagulants during their practice were the socio-demographic that significantly associated with high confidence level of pharmacist in providing pharmaceutical care on all types of anticoagulants (p < 0.05).

Conclusion
Pharmacists were found more confident in providing pharmaceutical care on warfarin compared to low molecular weight heparins and direct oral anticoagulants. Continuous educational and training programmes on the use of anticoagulants should be carried out to enhance pharmacists’ confidence in supporting patients’ care.
Linking strike directions to invariant TE and TM impedances of the magnetotelluric impedance tensor
Authors: Arellano-Castro Rocío F. , Gómez-Treviño Enrique 
Published: November 2021

AbstractEstimation of the traditional transverse electric (TE) and transverse magnetic (TM) impedances of the magnetotelluric tensor for two-dimensional structures can be decoupled from the estimation of the strike direction with significant implications when dealing with galvanic distortions. Distortion-free data are obtainable by combining a quadratic equation with the phase tensor. In the terminology of Groom–Bailey, the quadratic equation provides amplitudes and phases that are immune to twist, and the phase tensor provides phases immune to both, twist and shear. On the other hand, distortion-free strike directions can be obtained using Bahr's approach or the phase tensor. In principle, this is all that is needed to proceed to a two-dimensional (2D) interpretation. However, the resulting impedances are strike ignorant because they are invariant under coordinate system rotation, and if they are to be related to a geological strike, they must be linked to a particular direction. This is an additional ambiguity to the one of 90° arising in classic strike-determination methods, which must be resolved independently. In this work, we use the distortion model of Groom–Bailey to resolve the ambiguity by bringing back the coupling between impedances and strike in the presence of galvanic distortions. Our approach is a hybrid between existing numerical and analytical methods that reduces the problem to a binary decision, which involves associating the invariant impedances with the correct TE and TM modes. To determine the appropriate association, we present three algorithms. Two of them require optimizing the fit to the data, and the third one requires a comparison of phases. All three keep track of possible crossings of the phase curves providing a clear-cut solution. Synthetic and field data illustrate the performance of the three schemes.
Graphical Abstract
Breeding biology of the Green-backed Tit (Parus monticolus) in southwest China
Authors: Ye Ping , Yao Xiaogang , Bi Jianli , Li Guangrong , Liang Wei , Yang Canchao 
Published: November 2021

AbstractStudies on breeding biology enable us to broaden our understanding of the evolution of life history strategies. We studied the breeding biology of the Green-backed Tit (Parus monticolus) to provide comprehensive data on nest and egg characteristics, parental behavior throughout egg laying and nestling periods, and reproductive outcome. Our study reveals adaptive behavioral patterns and reproductive strategies forP. monticolus.
Impact of Spirulina corn soy blend on Iron deficient children aged 6–23 months in Ndhiwa Sub-County Kenya: a randomized controlled trial
Authors: Othoo Dorothy Apondi , Ochola Sophie , Kuria Elizabeth , Kimiywe Judith 
Published: November 2021

Abstract
Background
Iron deficiency anemia (IDA) remains high in Kenya despite interventions. Twenty-seven percent of children aged 6 months-14 years are anemic, with low iron intake (7%) among children aged 6–23 months. Standard food interventions involve a corn soy blend (CSB), which is limited in micronutrients, and fortifiers are not accessible locally. Moreover, the use of spirulina as a strategy for mitigating IDA has not been adequately documented. This study compared the impact of a spirulina corn soy blend (SCSB) on IDA among children aged 6–23 months.

Methods
A total of 240 children with IDA were randomly assigned to study groups at a ratio of 1:1:1 through lotteries, and caregivers and research assistants were blinded to group assignment. Dry-take-home SCSB, CSB and placebo flour (1.7 kg) was given to caregivers to prepare porridges using a flour water ratio of 1:4, producing 600 ml–700 ml of porridge to feed children 200 ml of porridge three times a day for 6 months. Impact was assessed as plasma hematocrit at baseline and after the study. Blood drawing, preparation and analysis were performed in accordance with approved procedures by the EthicsResearchCommittee. Monthly follow-up and data collection on dietary intake, anthropometry, morbidity and infant feeding practices were performed using questionnaires. Relative risk, magnitude of change and log-rank tests were used to compare the impact of the intervention, and significant differences were determined at P < 0.05.

Results
The survival probabilities for children consuming SCSB were significantly higher than those consuming CSB (log-rank-X2 = 0.978; CI: 0.954–1.033, P = 0.001) and the placebo (log-rankX2 = 0.971; CI: 0.943–0.984, P = 0.0001). Children consuming SCSB had a mean recovery time of 8 days (CI: 7–12 days) compared to those consuming CSB (19 days; CI: 20–23 days) and placebo (33 days; CI: 3 1–35 days). The recovery rate was 15.4 per 100 persons per day for children who consumed SCSB as opposed to 4.6 and 1.8 per 100 persons per day for those who consumed CSB and the placebo, respectively.

Conclusion
Management of IDA with SCSB compared to CSB and the placebo led to faster reversal and large numbers of recoveries from IDA. The recovery rates were above the World Health Organizations (WHO) minimums standards for food interventions. Efforts to realize high and faster recoveries from IDA should be heightened by fortifying CSB with spirulina powder.
Melanin production and laccase mediated oxidative stress alleviation during fungal-fungal interaction among basidiomycete fungi
Authors: Dullah Samim , Hazarika Dibya Jyoti , Goswami Gunajit , Borgohain Tanushree , Ghosh Alokesh , Barooah Madhumita , Bhattacharyya Ashok , Boro Robin Chandra 
Published: November 2021

AbstractFungal-fungal interaction often leads to the change in metabolite profile of both the interacting fungus which may have potential implication in industry or agriculture. In the present study, we performed two sets of fungal-fungal interaction—Trametes coccinea (F3) with Leiotrametes lactinea (F9) and T. coccinea (F3) with T. versicolor (F1) to understand the changes in the metabolite profile during the interaction process and how this process impacts the hyphal/mycelial morphology of the participating fungi. The metabolites produced during interaction of T. coccinea (F3) with L. lactinea (F9) and T. coccinea (F3) with T. versicolor (F1) was analysed through liquid chromatography coupled to mass spectroscopy (LC-MS). Most of the metabolites secreted or produced during interaction are associated with defensive response. Further, visualization with scanning electron microscopy revealed that interaction between the tested fungi led to the changes in the hyphal morphology. The bipartite fungal interaction resulted in the production of a dark brown colour pigment—melanin as confirmed by the LC-MS, FTIR and NMR analysis. Moreover, the fungal–fungal interaction also led to increase in the production of laccase, a group of multicopper oxidases involved in detoxification of toxic compounds. Further, increased activity of superoxide dismutase, an enzyme that catalyzes the dismutation of the superoxide anion to hydrogen peroxide was also recorded during fungal–fungal interaction. Quantitative real-time PCR revealed upregulation of lcc1 (encoding a laccase enzyme) and few other stress related genes of T. versicolor during its hyphal interaction with T. coccinea, suggesting a direct correlation between laccase production and melanin production.
Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin
Authors: Fontana Elisa , Meyers Jeff , Sobrero Alberto , Iveson Timothy , Shields Anthony F. , Taieb Julien , Yoshino Takayuki , Souglakos Ioannis , Smyth Elizabeth C. , Lordick Florian , Moehler Markus , Giraut Anne , Harkin Andrea , Labianca Roberto , Meyerhardt Jeffrey , André Thierry , Boukovinas Ioannis , Lonardi Sara , Saunders Mark , Vernerey Dewi , Oki Eiji , Georgoulias Vassilis , Ben-Aharon Irit , Shi Qian 
Published: November 2021

PURPOSE Early-onset (EO) colorectal cancer (CRC, age < 50 years) incidence is increasing. Decisions on optimal adjuvant therapy should consider treatment adherence, adverse events, and expected outcomes in a population with life expectancy longer than later-onset (LO) CRC (age ≥ 50 years). MATERIALS AND METHODS Individual patient data from six trials in the International Duration Evaluation of Adjuvant Chemotherapy database were analyzed. Characteristics, treatment adherence, and adverse events in stage II or III EO-CRC and LO-CRC were compared. To reduce confounders of non–cancer-related deaths because of age or comorbidities, time to recurrence (3-year relapse-free rate) and cancer-specific survival (5-year cancer-specific mortality rate) were considered. RESULTS Out of 16,349 patients, 1,564 (9.6%) had EO-CRC. Compared with LO-CRC, EO-CRC had better performance status (86% v 80%, P < .01), similar T stage (% T1-3/T4: 76/24 v 77/23, P = .97), higher N2 disease rate (24% v 22%, P < .01), more likely to complete the planned treatment duration (83.2% v 78.2%, P < .01), and received a higher treatment dose intensity, especially with 6-month regimens. Gastrointestinal toxicity was more common in EO-CRC; hematologic toxicity was more frequent in LO-CRC. Compared with LO-CRC, significantly worse cancer-specific outcomes were demonstrated especially in high-risk stage III EO-CRC: lower 3-year relapse-free rate (54% v 65%; hazard ratio [HR] 1.33; 95% CI, 1.14 to 1.55; P value < .001) and higher 5-year cancer-specific mortality rate (24% v 20%; HR 1.21; 95% CI, 1.00 to 1.47; P value < .06). In this subgroup, no difference was observed with 3 or 6 months of therapy, with equally poor disease-free survival rates (57% v 56%; HR 0.97; 95% CI, 0.73 to 1.29; P value = .85). CONCLUSION Young age is negatively prognostic in high-risk stage III CRC and associated with significantly higher relapse rate; this is despite better treatment adherence and higher administered treatment intensity, suggesting more aggressive disease biology.
A Framework for Estimating Migrant Stocks Using Digital Traces and Survey Data: An Application in the United Kingdom
Authors: Rampazzo Francesco , Bijak Jakub , Vitali Agnese , Weber Ingmar , Zagheni Emilio 
Published: November 2021

Abstract
An accurate estimation of international migration is hampered by a lack of timely and comprehensive data, and by the use of different definitions and measures of migration in different countries. In an effort to address this situation, we complement traditional data sources for the United Kingdom with social media data: our aim is to understand whether information from digital traces can help measure international migration. The Bayesian framework proposed is used to combine data from the Labour Force Survey (LFS) and the Facebook Advertising Platform to study the number of European migrants in the United Kingdom, with the aim of producing more accurate estimates of the numbers of European migrants. The overarching model is divided into a Theory-Based Model of migration and a Measurement Error Model. We review the quality of the LFS and Facebook data, paying particular attention to the biases of these sources. The results indicate visible yet uncertain differences between model estimates using the Bayesian framework and individual sources. Sensitivity analysis techniques are used to evaluate the quality of the model. The advantages and limitations of this approach, which can be applied in other contexts, are discussed. We cannot necessarily trust any individual source, but combining them through modeling offers valuable insights.
NF-κB determines Paneth versus goblet cell fate decision in the small intestine
Authors: Brischetto Cristina , Krieger Karsten , Klotz Christian , Krahn Inge , Kunz Séverine , Kolesnichenko Marina , Mucka Patrick , Heuberger Julian , Scheidereit Claus , Schmidt-Ullrich Ruth 
Published: November 2021

ABSTRACT
Although the role of the transcription factor NF-κB in intestinal inflammation and tumor formation has been investigated extensively, a physiological function of NF-κB in sustaining intestinal epithelial homeostasis beyond inflammation has not been demonstrated. Using NF-κB reporter mice, we detected strong NF-κB activity in Paneth cells, in ‘+4/+5’ secretory progenitors and in scattered Lgr5+ crypt base columnar stem cells of small intestinal (SI) crypts. To examine NF–κB functions in SI epithelial self-renewal, mice or SI crypt organoids (‘mini-guts’) with ubiquitously suppressed NF-κB activity were used. We show that NF-κB activity is dispensable for maintaining SI epithelial proliferation, but is essential for ex vivo organoid growth. Furthermore, we demonstrate a dramatic reduction of Paneth cells in the absence of NF-κB activity, concomitant with a significant increase in goblet cells and immature intermediate cells. This indicates that NF-κB is required for proper Paneth versus goblet cell differentiation and for SI epithelial homeostasis, which occurs via regulation of Wnt signaling and Sox9 expression downstream of NF-κB. The current study thus presents evidence for an important role for NF-κB in intestinal epithelial self-renewal.
Inflammatory Arthropathy in the Elite Sports Athlete
Authors: Kin-Hoo Koo Kenneth , Chinoy Hector , Creaney Leon , Hayton Mike 
Published: November 2021

Abstract
Elite athletes commonly present with joint pains that are attributed to overuse injuries though on occasion it can be due to an inflammatory arthropathy. The diagnostic challenge is that presenting symptoms of benign injuries are similar to inflammatory arthropathies. A holistic review of the athlete can provide clues suggestive of inflammatory arthropathy, before requesting further investigations to confirm the diagnosis. Current imaging modalities are not specific in differentiating inflammatory arthritis with other causes of joint inflammation. Prompt treatment is required to restore the athlete to an optimum level of activity and prevent career ending disability, all in adherence to the regulations of the sporting governing bodies. This review aims to highlight the importance of inflammatory arthropathy in the differentials for an athlete presenting with joint pains.
Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan
Authors: Ahmed Sheraz , Iqbal Najeeha , Sadiq Kamran , Umrani Fayaz , Rizvi Arjumand , Jamil Zehra , Syed Sana , Khan Marium , Iqbal Junaid , Qureshi Shahida , Hotwani Aneeta , Rahman Najeeb , Moore Sean , Ali Asad 
Published: November 2021

The Study of Environmental Enteropathy (EE) and Malnutrition in Pakistan (SEEM) is a community intervention trial designed to understand the pathophysiology of EE and its associated clinical phenotypes in children less than two years of age. Undernutrition is the underlying cause of three million deaths worldwide annually, accounting for 45% of all deaths among children under five years of age. Linear growth stunting affects a further 165 million, especially in low- and middle-income countries. In Pakistan, an estimated one in three children are underweight and nearly half are stunted. This manuscript summarizes the challenges faced by the field team and the solutions employed for achieving our research objectives at the rural Matiari field site. Our study design involved a longitudinal collection of field data and biological samples which required constant engagement of field staff with the participating families. Challenges faced in SEEM included: 1) quality assurance parameters of anthropometry data; 2) 24-hour food recall data collection; 3) clinical management of sick enrolled children; 4) obtaining informed consent for upper gastrointestinal (UGI)endoscopy (an invasive procedure); and 5) biological sample collection (blood, urine, stool) from enrolled children. We enrolled 350 malnourished children(Weight for Height Z (WHZ) score <-2) and 50 well-nourished children(WHZ score ≥ 0 and height-for-age Z (HAZ) score ≥ -1) with more than 95% success rate of collecting blood, urine and stool specimens. We collected 72% microbiome stool samples within 30 minutes of the child passing stool. We conducted a UGI biopsy in 63 children.  Solutions to these challenges included good project governance, the establishment of credibility, and the development of a longitudinal bidirectional relationship embedded in trust and effective communication with the caretakers of the enrolled children.    Continuous monitoring, regular training of staff, and effective teamwork were key factors that led to the successful execution of our study.
Exact Branch-Price-and-Cut for a Hospital Therapist Scheduling Problem with Flexible Service Locations and Time-Dependent Location Capacity
Authors: Jungwirth Alexander , Desaulniers Guy , Frey Markus , Kolisch Rainer 
Published: November 2021

We study a new variant of the vehicle routing problem, which arises in hospital-wide scheduling of physical therapists. Multiple service locations exist for patients, and resource synchronization for the location capacities is required as only a limited number of patients can be treated at one location at a time. Additionally, operations synchronization between treatments is required as precedence relations exist. We develop an innovative exact branch-price-and-cut algorithm including two approaches targeting the synchronization constraints (1) based on branching on time windows and (2) based on adding combinatorial Benders cuts. We optimally solve realistic hospital instances with up to 120 treatments and find that branching on time windows performs better than adding cutting planes. Summary of Contribution: We present an exact branch-price-and-cut (BPC) algorithm for the therapist scheduling and routing problem (ThSRP), a daily planning problem arising at almost every hospital. The difficulty of this problem stems from its inherent structure that features routing and scheduling while considering multiple possible service locations with time-dependent location capacities. We model the ThSRP as a vehicle routing problem with time windows and flexible delivery locations and synchronization constraints, which are properties relevant to other vehicle routing problem variants as well. In our computational study, we show that the proposed exact BPC algorithm is capable of solving realistic hospital instances and can, thus, be used by hospital planners to derive better schedules with less manual work. Moreover, we show that time window branching can be a valid alternative to cutting planes when addressing synchronization constraints in a BPC algorithm.
BIG DATA AND DECISION-MAKING SUPPORT
Authors: Procházka Peter 
Published: November 2021

INTRODUCTION: Nowadays, Big Data is created in previously unimaginable quantities. Newly generated data from various Internet of Things (IoT) sensors and their use have never reached their current dimensions. Along with this trend, the availability of devices capable of collecting this data increases, the time for their evaluation is reduced and the volume of data collected at the same time increases. The most important task of research and development in this area is to bring solutions suitable for processing large amounts of data because our current storage and processing capabilities are limited and unable to compete with the storage, processing and publication of the resulting data.
OBJECTIVES: Point out the importance of implementing Big Data technology.
METHODS: To achieve the goal, the following methodological approach was chosen: study and processing of foreign and domestic literature, acquaintance with similar solutions for data processing, definition of Big Data and IoT, proposal for using Big Data solution to support decision-making, risk definition and evaluation.
RESULTS: With the growing amount of disparate and incoherent data and the further growth of the Internet of Things, it is now almost impossible to evaluate all available information correctly and in a timely manner. Without this knowledge, the company loses its competitive advantage and is unable to respond in a timely manner to client requests.
CONCLUSION: Implementing a solution for processing Big Data to support decision-making in the company is a complex process. As part of the implementation and use of the Big Data solution to support decision-making, the company must be prepared for the emergence of various problems. We can assume that Big Data technology will constantly be evolving in terms of streamlining analytical tools for obtaining information from large volumes of generated data. Therefore, it is appropriate to create space for the implementation of Big Data technology.