bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Biology of BDSM: A Systematic Review
Authors: Wuyts Elise , Morrens Manuel 
Published: December 2021

ABSTRACTIntroductionBDSM is an abbreviation used to reference the concepts of bondage and discipline, dominance and submission, sadism and masochism, enacted by power exchanges between consensual partners. In recent years, attention has shifted from the idea of BDSM as a pathological and tabooed niche practice towards viewing BDSM as a healthy form of intimacy.AimThis systematic review brings together all existing literature on the biology of BDSM and places it in a broader biological context.MethodsA systematic search was conducted on PubMed, Web of Science and PsycARTICLES, of which 10 articles are included and discussed in this systematic review.ResultsThere is evidence for cortisol changes in submissives as a result of a BDSM interaction, suggesting involvement of the physiological stress system. Endocannabinoid changes implicate the pleasure and reward system. In dominants, this biologically measured pleasure seemed to be dependent on power play rather than pain play. Testosterone and oxytocin are also implicated in BDSM, though their role is less evident. Research into brain region activity patterns related to BDSM interest suggests a role for the parietal operculum and ventral striatum in the context of the pleasure and reward system, the primary and secondary somatosensory cortex in the context of pain perception, empathy-related circuits such as the anterior insula, anterior midcingulate cortex and sensorimotor cortex and the left frontal cortex in the context of social and sexual interactions. Pain thresholds are shown to be higher in submissive individuals and a BDSM interaction may cause pain thresholds to rise in submissives as well.ConclusionBDSM interactions are complex and influenced by several psychological, social and biological processes. Though research is limited, there is emerging evidence for an interaction between several biological systems involved in these types of interests and activities. This means there is an important role for future research to replicate and supplement current results.
Sincere Cooperation between EU and Member States in the Field of Readmission: The More the Merrier?
Authors: MOLINARI Caterina 
Published: December 2021

AbstractCooperation with third countries on readmission has occupied an increasingly prominent place in the EU's migration management strategy. The EU and its Member States have progressively concluded an extensive set of bilateral and multilateral, binding and non-binding, cooperation instruments on readmission. This proliferation questions the field's coherence with the principle of sincere cooperation, governing the interplay between the Union's and Member States’ action. By taking this principle as a benchmark, the article highlights the ineffective nature of the current ‘unprincipled’ pursuit of readmission goals. It also demonstrates that sincere cooperation—if read together with subsidiarity—does not necessarily favour the Union's international action, to the detriment of the Member States’. Rather, it requires a good faith effort to identify, and stand by, the most effective level of action.
Diets with higher insulinaemic potential are associated with increased risk of overall and cardiovascular disease-specific mortality
Authors: Wang Yingying , Chen Bo , Zhang Jiawei , Li Hairong , Zeng Xufen , Zhang Zhuang , Zhu Yu , Li Xiude , Hu Anla , Zhao Qihong , Yang Wanshui 
Published: December 2021

AbstractHyperinsulinaemia and insulin resistance have been proposed to be associated with mortality risk, and diet can modulate insulin response. However, whether dietary patterns with high insulinaemic potential are associated with mortality remains unknown. We prospectively examined the associations between hyperinsulinaemic diets and the risk of total and cause-specific mortality in a large nationally representative population. Dietary factors were assessed by 24-h recalls. Two empirical dietary indices for hyperinsulinaemia (EDIH) and insulin resistance (EDIR) were developed to identify food groups most predictive of biomarkers for hyperinsulinaemia (C-peptide and insulin) and insulin resistance (homoeostatic model assessment for insulin resistance), respectively. Deaths from date of the first dietary interview until 31 December 2015 were identified by the National Death Index. Multivariable hazard ratios (HR) and 95 % CI were calculated using Cox regression models. During a median follow-up of 7·8 years, 4904 deaths were documented among 40 074 participants. For EDIH, the multivariable-adjusted HR (comparing extreme quintiles) were 1·20 (95 % CI 1·09, 1·32, P-trend<0·001) for overall mortality and 1·41 (95 % CI 1·15, 1·74, P-trend = 0·002) for CVD mortality. Similar associations were observed for EDIR with HR of 1·18 (95 % CI 1·07, 1·29, P-trend < 0·001) for total and 1·35 (95 % CI 1·09, 1·67, P-trend = 0·005) for CVD mortality. After further adjustments for BMI and diabetes, these positive associations were somewhat attenuated. Our findings suggested that diets with higher insulinaemic potential are associated with increased risk of overall and CVD-specific mortality.
Participation Improves Collective Decisions (When It Involves Deliberation): Experimental Evidence From Kenya
Authors: Grillos Tara 
Published: December 2021

AbstractCitizen participation in decision making has been widely lauded as a method for improving societal outcomes. Deliberative discussion, in particular, is believed to be more transformative than a mere aggregation of individual preferences, leading to more socially optimal decision making and behavior. I report the results from a laboratory experiment with 570 subjects in Nairobi, directly testing the effect of participation in deliberative group decision making on collective outcomes. Participants engage in a group task to earn compensation toward a shared group fund. Randomly assigned treatments vary according to whether decision making over the task to be completed involves: (1) external assignment; (2) non-deliberative majority voting; or (3) consensus through deliberative discussion. I find that deliberation improves collective decision making. Deliberation is also associated with changes in preferences, greater agreement with decision outcomes, and greater perceived fairness. Evidence for behavior change is weaker, but there is some support for further research into the relationship between preference change and behavior change.
Comparison of culture-dependent and culture-independent techniques in the detection of lactic acid bacteria biodiversity and dynamics throughout the ripening process: The case of Turkish artisanal Tulum cheese produced in the Anamur region
Authors: Demirci Talha , Oraç Aysun , Aktaş Kübra , Dertli Enes , Akyol Ismail , Akın Nihat 
Published: December 2021

AbstractOur objective was to analyze the diversity of the microbiota over 180 d of ripening of eight batches of artisanal goatskin Tulum cheeses by culture-dependent and culture-independent (PCR-DGGE) methods. V3 region of the bacterial 16S rRNA gene was amplified with the PCR after direct DNA isolation from the cheese samples. Nine different species and five genera were determined by culturing, while 11 species were identified in the PCR-DGGE technique. This diversity revealed the uniqueness of artisanal cheese varieties. The dominant genera in all the cheese samples were composed of Enterococcus species. The culture-dependent method revealed five genera (Enterococcus,Bacillus,Lactococcus,Lactobacillus, Sphingomonas) while three genera (Enterococcus, Streptococcus, Lactococcus) were detected in the culture-independent method. It was concluded that combining the two methods is important for characterizing the whole microbiota of the Tulum cheese varieties produced in the Anamur region.
Developments in effective use of volatile organic compound analysis to assess flavour formation during cheese ripening
Authors: Yavuz Mustafa , Kasavi Ceyda , Toksoy Öner Ebru 
Published: December 2021

AbstractIn the burgeoning demand for optimization of cheese production, ascertaining cheese flavour formation during the cheese making process has been the focal point of determining cheese quality. In this research reflection, we have highlighted how valuable volatile organic compound (VOC) analysis has been in assessing contingent cheese flavour compounds arising from non-starter lactic acid bacteria (NSLAB) along with starter lactic acid bacteria (SLAB), and whether VOC analysis associated with other high-throughput data might help provide a better understanding the cheese flavour formation during cheese process. It is widely known that there is a keen interest to merge all omics data to find specific biomarkers and/or to assess aroma formation of cheese. Towards that end, results of VOC analysis have provided valuable insights into the cheese flavour profile. In this review, we are pinpointing the effective use of flavour compound analysis to perceive flavour-forming ability of microbial strains that are convenient for dairy production, intertwining microbiome and metabolome to unveil potential biomarkers that occur during cheese ripening. In doing so, we summarised the functionality and integration of aromatic compound analysis in cheese making and gave reflections on reconsidering what the role of flavour-based analysis might have in the future.
Environmental contamination with parasites in selected rural farms in the Philippines: impacts of farming practices on leafy greens food safety
Authors: Paller Vachel Gay V. , Macalinao-Ramirez Constance Aurelle , Bandal Modesto Z. 
Published: December 2021

AbstractFresh vegetables are an important part of a healthy diet, however, they can also be agents of transmission of intestinal parasites. This study aimed to evaluate the presence of parasite contamination in vegetable farms as a source of transmission in selected rural communities in Laguna, Philippines. A total of 168 vegetable, 55 soil and 15 water samples collected from four selected farms and a reference farm were processed through various standard parasitological techniques. Of these, 17.3% of vegetables, 47.3% soil and 73.3% water samples were found contaminated with parasites’ eggs or cysts. Interestingly, leafy vegetables, such as lettuce, were found to be more contaminated. Results showed that strongylids/hookworms (egg/larva) showed the highest prevalence in farm soil (38.2%) and vegetable (13.1%); other helminth parasite eggs were also recovered such as Toxocara sp., Ascaris sp., Trichiuris, Trichostrongylus sp. and protozoan cysts of Balantidium coli. Cryptosporidium sp. oocysts of and Giardia sp. cysts were observed in all water samples in the farms. Furthermore, results revealed that some farming practices such as the use of improperly treated animals manure as fertilizers, unhygienic practice of farmers and sanitation issues were factors that contribute to parasite contamination in the farms. These findings have implications on food safety in poor-resource communities posing public health risks. Recommendations were discussed in the study for the control and prevention of parasite contamination at the farm level.
Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression
Authors: Shunkai Lai , Su Ting , Zhong Shuming , Chen Guangmao , Zhang Yiliang , Zhao Hui , Chen Pan , Tang Guixian , Qi Zhangzhang , He Jiali , Zhu Yunxia , Lv Sihui , Song Zijin , Miao Haofei , Hu Yilei , Jia Yanbin , Wang Ying 
Published: December 2021

AbstractBackgroundPrevious studies have demonstrated structural and functional changes of the hippocampus in patients with major depressive disorder (MDD). However, no studies have analyzed the dynamic functional connectivity (dFC) of hippocampal subregions in melancholic MDD. We aimed to reveal the patterns for dFC variability in hippocampus subregions – including the bilateral rostral and caudal areas and its associations with cognitive impairment in melancholic MDD.MethodsForty-two treatment-naive MDD patients with melancholic features and 55 demographically matched healthy controls were included. The sliding-window analysis was used to evaluate whole-brain dFC for each hippocampal subregions seed. We assessed between-group differences in the dFC variability values of each hippocampal subregion in the whole brain and cognitive performance on the MATRICS Consensus Cognitive Battery (MCCB). Finally, association analysis was conducted to investigate their relationships.ResultsPatients with melancholic MDD showed decreased dFC variability between the left rostral hippocampus and left anterior lobe of cerebellum compared with healthy controls (voxel p < 0.005, cluster p < 0.0125, GRF corrected), and poorer cognitive scores in working memory, verbal learning, visual learning, and social cognition (all p < 0.05). Association analysis showed that working memory was positively correlated with the dFC variability values of the left rostral hippocampus-left anterior lobe of the cerebellum (r = 0.338, p = 0.029) in melancholic MDD.ConclusionsThese findings confirmed the distinct dynamic functional pathway of hippocampal subregions in patients with melancholic MDD, and suggested that the dysfunction of hippocampus-cerebellum connectivity may be underlying the neural substrate of working memory impairment in melancholic MDD.
Robust control of robot manipulators with an adaptive fuzzy unmodelled parameter estimation law
Authors: Burkan Recep , Mutlu Askin 
Published: December 2021

SummaryFor robot manipulators, there are two types of disturbances. One is model parametric uncertainty; the other is unmodelled parameters such as joint friction forces and external disturbances. Unmodelled joint frictions and external disturbances reduce performance in terms of positioning accuracy and repeatability. In order to compensate for unmodelled parameters, the design of a new controller is considered. First, the modelled and unmodelled parameters are included in a dynamic model. Then, based on the dynamic model, a new Lyapunov function is developed. After that, new nonlinear joint friction and external disturbance estimation laws are derived as an analytic solution from the Lyapunov function; thus, the stability of the closed system is guaranteed. Better values of the adaptive dynamic compensators can be extracted by fuzzy rules according to the tracking error. Limitations and knowledge about friction and external disturbances are not required for the design of the controller. The controller compensates for all possible model parameter uncertainties, all possible unknown joint frictions and external disturbances.
Dramatic shift in the epidemiology of peptic ulcer in Japan: the impact of Helicobacter pylori eradication therapy
Authors: Lee K. D. , Kayano T. , Nishiura H. 
Published: December 2021

Abstract
Helicobacter pylori eradication therapy was included with insurance coverage from 1999 onwards in Japan, with the incidence of peptic ulcer expected to decrease as a consequence. This study investigated the temporal dynamics of peptic ulcer in Japan and identified underlying contributory factors using mathematical models. We investigated the seroprevalence of H. pylori and analysed a snapshot of peptic ulcer cases. Ten statistical models that incorporated important events – H. pylori infection, the cohort effect, eradication therapy and the natural trend for reduction – were fitted to the case data. The hazard of infection with H. pylori was extracted from published estimates. Models were compared using the Akaike information criterion (AIC), and factor contributions were quantified using the coefficient of determination. The best-fit model indicated that 88.1% of the observed snapshot of cases (AIC = 289.2) included the effects of (i) H. pylori infection, (ii) the cohort effect and (iii) eradication therapy, as explanatory variables, the contributions of which were 80.8%, 4.0% and 3.2%, respectively. Among inpatients, a simpler model with (i) H. pylori infection only was favoured (AIC = 107.7). The time-dependent epidemiological dynamics of peptic ulcers were captured and H. pylori infection and eradication therapy explained ⩾84% of the dramatic decline in peptic ulcer occurrence.
Accuracy of the Apple Watch single-lead ECG recordings in pre-term neonates
Authors: Paech Christian , Kobel Maria , Michaelis Anna , Gebauer Roman Antonin , Kalden Philipp , Dähnert Ingo , Thome Ulrich , Markel Franziska , Rützel Sebastian 
Published: December 2021

AbstractIntroduction:Telemedicine gained an increasing use throughout the last years. Lifestyle tools like the Apple watch seem to have an increasing spread even in remote areas and underdeveloped regions. The increasing availability of these tools offers the chance to use the health care functions of these devices to improve provision of professional medical care. First data on the use of the Apple Watch as a remote monitoring device in children have been reported, showing good acceptability and usability of the Apple Watch for symptom monitoring in children. This study aimed to evaluate the accuracy of the Apple Watch iECG in comparison to a standard 12-lead ECG in pre-term babies.Methods:In this prospective, single-arm study, consecutive preterm neonates hospitalised in Leipzig University Hospital neonatal ICU were eligible. A 12-lead ECG and an iECG using Apple Watch 4 were performed. iECG and 12-lead ECG measurements were performed by a paediatric cardiologist. Cardiac rhythm was classified and amplitudes and timing intervals were analysed for comparability.Results:Fifty preterm neonates, gestational week (23–36 weeks), and body weight (0.65–3.09 kg) were enrolled. Overall good quality and excellent correlation of the Apple Watch generated iECG in comparison to the standard 12-lead ECG could be demonstrated (p < 0.001). When interpreted by a paediatric cardiologist, a correct rhythm classification could be done in 100% of cases.Conclusion:The Apple Watch iECG seems to be a valuable tool to record an ECG comparable to lead I of the standard 12-lead ECG even in pre-term neonates. With a widespread availability and excellent connectivity, the Apple Watch iECG function may provide practitioners with a tool to send an iECG for interpretation to a paediatric cardiac specialist.
Comparison of Standard Technique, Ultrasonography, and Near-Infrared Light in Difficult Peripheral Vascular Access: A Randomized Controlled Trial
Authors: Yalçınlı Sercan , Karbek Akarca Funda , Can Özge , Uz İlhan , Konakçı Gülbin 
Published: December 2021

AbstractObjectives:Successful placement of a peripheral intravenous catheter (PIVC) on the first attempt is an important outcome for difficult vascular access (DVA) patients. This study compared standard technique, ultrasonography (USG), and near-infrared light (NIR) in terms of success in the first attempt in patients with DVA.Methods:This was a prospective, randomized controlled study. The study was conducted in a tertiary care hospital. Emergency department patients who describe DVA history, have no visible or palpable veins, and were assessed by the nurse to have a difficult PIVC were included to study. The PIVC procedure was performed on patients by standard, USG, or NIR device techniques. For all approaches, the success of the first attempt was the primary aim. Total procedure time, the total number of attempts, and the need for rescue intervention were secondary aims.Results:This study evaluated 270 patients. The first attempt success rates for USG, standard, and NIR methods were 78.9%, 62.2%, and 58.9%, respectively. The rate of first attempt success was higher in patients who underwent USG (USG versus standard, P = .014; USG versus NIR, P = .004; standard versus NIR, P = .648). The total median (IQR) procedure time for USG, standard, and NIR methods was 107 (69-228), 72 (47-134), and 82 (61-163) seconds, respectively. The total procedure time was longer in patients undergoing USG (standard versus USG, P <.001; NIR versus USG, P = .035; standard versus NIR, P = .055). The total median (IQR) number of attempts of USG, standard, and NIR methods were 1 (1-1), 1 (1-2), and 1 (1-2), respectively. A difference was found among the groups regarding the total number of attempts (USG versus NIR, P = .015; USG versus standard P = .108; standard versus NIR, P = .307). No difference was found among groups in terms of the need for rescue methods.Conclusion:It was found that USG increases the success of the first attempt compared with the standard method and NIR in patients with DVA.
Identification of elite germplasm of medicinally important Andrographis paniculata (Burm. f.) Nees with high content of four active diterpenoids in aerial parts from wild populations of eastern India
Authors: Champati Bibhuti Bhusan , Padhiari Bhuban Mohan , Ray Asit , Jena Sudipta , Sahoo Ambika , Halder Tarun , Ghosh Biswajit , Kar Basudeba , Panda Pratap Chandra , Nayak Sanghamitra 
Published: December 2021

AbstractAndrographis paniculata is an Indian medicinal plant with tremendous therapeutic values due to the presence of active diterpenoids in its aerial parts. However, high domestic and export demand has led to overexploitation of wild populations of this species. With a view to bringing A. paniculata into cultivation and to reduce the pressure on wild populations, the present study was undertaken to identify elite germplasm from different locations of eastern India by analysing intraspecific variation in the content of four major active diterpenoids. A total of 166 wild accessions of A. paniculata analysed through high-performance liquid chromatography (HPLC) revealed remarkable variation in the sum of four active diterpenoids in the aerial parts, ranging from 0.41 to 8.55% on a dry weight basis. Three elite accessions (AP-6, AP-8, AP-46) having respectively 8.02, 8.36 & 8.55% of the sum of four major active diterpenoids were identified. These germplasm could be used for commercial cultivation and genetic improvement of A. paniculata.
Stit-LOGIC FOR IMAGINATION EPISODES WITH VOLUNTARY INPUT
Authors: BADURA CHRISTOPHER , WANSING HEINRICH 
Published: December 2021

AbstractFrancesco Berto proposed a logic for imaginative episodes. The logic establishes certain (in)validities concerning episodic imagination. They are not all equally plausible as principles of episodic imagination. The logic also does not model that the initial input of an imaginative episode is deliberately chosen.Stit-imagination logic models the imagining agent’s deliberate choice of the content of their imagining. However, the logic does not model the episodic nature of imagination. The present paper combines the two logics, thereby modelling imaginative episodes with deliberately chosen initial input. We use a combination ofstit-imagination logic and a content-sensitive variably strict conditional à la Berto, for which we give a Chellas–Segerberg semantics. The proposed semantics has the following advantages over Berto’s: (i) we model thedeliberate choiceof initial input of imaginative episodes (in a multi-agent setting), (ii) we showframe correspondencesfor axiomatic analogues of Berto’s validities, which (iii) allows thepossibility to disregard axiomsthat might be considered not plausible as principles concerning imaginative episodes. We do not take a definite stance on whether theseshouldbe disregarded but give reasons for why one might want to disregard them. Finally, we compare our semantics briefly with recent work, which aims to model voluntary imagination, and argue that our semantics models different aspects.