bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Data Processing for Efficient Development
of multimodal Machine Learning Models in Tool Wear
Detection
Authors: ValizadehSotubadi Saleh , Mahjourian Nazanin , Nguyen Vinh 
Published: December 2024

Abstract

This study aims to develop an Automated Data Processing (ADP) framework that automatically processes multimodal data for machine learning (ML) diagnostics of manufacturing processes. The objective is to contribute to the state-of-the-art Automated ML (AutoML) domain by developing a novel all-in-one ML development framework that automatically processes data, trains ML models, and conducts evaluation based on prior process-based knowledge. For this purpose, the ADP framework was designed based on a higher level decision making unit and a lower level machine learning unit to select the best set of data processing methods, ML models, and training strategies, defined as policies, for the machine tool monitoring. The ADP framework was tested with data collected from orthogonal tube turning experiments for cutting tool wear classification. The data were gathered using acceleration, acoustics, and temperature sensors mounted on a Computer Numerical Controller (CNC) lathe machine. The results demonstrate that the solutions selected by the ADP framework consistently exhibited similar performance as the global optimal policy with improved computational efficiency. Consequently, the proposed ADP framework was demonstrated to automatically conduct multiple steps within the ML development process without manual intervention for tool condition monitoring to facilitate democratization of ML development for manufacturers.
PFDB: Polyphenol Family Database
Authors: Li Xuzhen , Wang Chunping , Ning Ya , Zhu Yifan , Peng Xiaochang , Wang Weibin , Hao Tingting , Chen Baozheng , Yang Ling , Wang Lei , Cheng Jia , Li Dawei , Sheng Jun 
Published: December 2024

Abstract

Polyphenols and their derivatives are pivotal bioactive compounds in the plant kingdom and are known for their diverse physiological effects and significant contributions to human health. Understanding their biosynthetic pathways is crucial for exploring their roles in plant defense, environmental adaptation, and human nutrition. This study introduces the Polyphenol Family Database (PFDB, url: http://pfdb.ynau.edu.cn), a comprehensive and user-friendly resource designed to facilitate the exploration and analysis of these compounds. PFDB consolidates information on 64 enzymes across 284 species, offering a comprehensive view of their biosynthetic pathways and evolutionary relationships. The database features an intuitive structure with six main sections, including detailed pathway maps and a species-enzyme detail page that provides in-depth information on specific enzymes and their genetic and phylogenetic context. This integration of biochemical and genetic data makes PFDB a valuable tool for researchers in plant biology, biochemistry, and nutrition, facilitating advanced research and comparative analyses in the field. URL: http://pfdb.ynau.edu.cn
Polymerase chain reactions on nucleic acids isolated from in situ collected small intestinal mucosal swabs may represent alternative tests to diagnose Echinococcus multilocularis infection in its definitive hosts
Authors: Kunisch Alrik-Markis , Wassermann Josefine , Peters Martin , Feldmann Kim , Prinzenberg Eva , Klink Jana C. , Bergmann Hannes , Wernike Kerstin , Maksimov Pavlo , Schares Gereon 
Published: December 2024

Abstract

Background
The cestode Echinococcus multilocularis parasitizes the small intestines of carnivores such as foxes (Vulpes vulpes) and raccoon dogs (Nyctereutes procyonoides) as definitive hosts and represents an important zoonotic threat. This study aimed to determine whether E. multilocularis DNA detection methods involving easy-to-collect sample types, such as swabs could represent alternatives to traditional parasitological techniques.
Methods
Three analytes from foxes and raccoon dogs were tested. i. Swabs taken immediately during necropsy (in-situ) from the small intestinal mucosa (FastMucSwab), ii. swabs from scraped-off small intestinal mucosa (IsolMucSwab), also used for the sedimentation-counting-technique (SCT) and for comparative reasons iii. feces from the Ampulla recti. Initial analyses on the suitability of two real-time PCRs (Em‒qPCR1 and Em-qPCR2) for the detection of E. multilocularis DNA isolated from swabs from SCT-positive animals (n = 15) suggested Em-qPCR1 as superior in terms of sensitivity. Another subset of SCT-positive and -negative animals was used to test FastMucSwabs taken separately from four segments of the small intestine (n = 81). For the comparisons of FastMucSwab Em-qPCR1 vs IsolMucSwab Em-qPCR1 and FastMucSwab Em-qPCR1 vs SCT, samples from 408 or 508 animals, respectively, were used. The comparison of Em-qPCR1 results on fecal samples and FastMucSwab relative to SCT, involved samples from 105 animals.
Results
Only minor differences in E. multilocularis DNA detection, independent of sample type, were observed. High levels of concordance between Em-qPCR1 results were noted in the comparison of results on FastMucSwabs, IsolMucSwabs or feces. The agreement between FastMucSwab and IsolMucSwab was excellent (Kappa 0.86 [95% CI: 0.79–0.92]). If inconclusive PCR results were excluded, FastMucSwab Em-qPCR1 had a diagnostic sensitivity of 92.7% (95% CI: 83.0–97.3%) and a specificity of 91.5% (95% CI: 88.4–93.9%) relative to SCT. Compared with SCT, Feces Em-qPCR1 had a diagnostic sensitivity of 82.8% (95% CI: 63.5–93.5%) and a specificity of 90.9% (95% CI: 81.4–95.9%). Segmental swabbing had no diagnostic advantages. Overall, there was evidence that the DNA detection methods used here had a higher diagnostic sensitivity than SCT did.
Conclusion
The present study provides evidence that simple alternative methods, such as the Em-qPCR1 on FastMucSwabs represent an efficient tool for performing larger-scale epidemiological studies.
Crystallization kinetics of poly(ε-caprolactone) and chlorinated polyethylene binary blends
Authors: Mamun Al 
Published: December 2024

Abstract

The crystallization kinetics of poly(ε-caprolactone) (PCL) and chlorinated polyethylene (CPE) binary blends were investigated, focusing on the effects of varying CPE content and chlorine concentration. Differential scanning calorimetry (DSC) and polarized optical microscopy were used to study the non-isothermal and isothermal crystallization kinetics. The results show that addition of CPE significantly influenced the crystallization behavior of PCL, and the extent of this effect was strongly dependent on the chlorine content of the CPE. Blends with a higher chlorine content (48%) in CPE exhibited enhanced interactions and higher miscibility with PCL, whereas the lower chlorine content (25%) indicated the immiscible nature of the blends. The interaction energy density calculations supported the presence of stronger PCL-CPE interactions at higher chlorine concentrations. Owing to the higher miscibility, increasing the CPE content in the PCL/CPE blend decreased the relative crystallinity, lowered the melting peak, reduced the crystal growth rate, and slowed the overall crystallization process. These effects were more pronounced at higher chlorine levels, whereas lower chlorine levels were not significantly affected by the immiscible nature of the blend. The blend composition and crystallization temperature influenced the crystallization kinetics and melting behavior. Higher CPE concentrations resulted in less perfect and heterogeneous crystalline structures. These findings contribute to a better understanding of the crystallization kinetics of PCL/CPE blends and provide valuable insights for specific applications.
Climate-driven variation in the phenology of juvenile Ixodes pacificus on lizard hosts
Authors: Sambado Samantha , Sparkman Amanda , Swei Andrea , MacDonald Andrew J , Young Hillary S , Salomon Jordan , Crews Arielle , Ring Kacie , Copeland Stephanie , Briggs Cheryl J 
Published: December 2024

Abstract

Background
Ectothermic arthropods, like ticks, are sensitive indicators of environmental changes, and their seasonality plays a critical role in tick-borne disease dynamics in a warming world. Juvenile tick phenology, which influences pathogen transmission, may vary across climates, with longer tick seasons in cooler climates potentially amplifying transmission. However, assessing juvenile tick phenology is challenging in climates where desiccation pressures reduce the time ticks spend seeking blood meals. To improve our understanding of juvenile tick seasonality across a latitudinal gradient, we examine Ixodes pacificus phenology on lizards, the primary juvenile tick host in California, and explore how climate factors influence phenological patterns.
Methods
Between 2013 and 2022, ticks were removed from 1,527 lizards at 45 locations during peak tick season (March-June). Tick counts were categorized by life stage (larvae and nymphs) and linked with remotely sensed climate data. Juvenile phenology metrics, including abundance, date of peak abundance, and temporal overlap between larval and nymphal populations, were analyzed along a latitudinal gradient, including tick abundances on lizards, Julian date of peak mean abundance. Generalized Additive Models (GAMs) were applied to assess climate-associated variation in juvenile abundance on lizards.
Results
Mean tick abundance per lizard ranged from 0.17 to 47.21 across locations, with the highest in the San Francisco Bay Area and lowest in Los Angeles, where more lizards had zero ticks attached. In the San Francisco Bay Area, peak nymphal abundance occurred 25 days earlier than peak larval abundance. Temporal overlap between larval and nymphal stages at a given location varied regionally, with northern areas showing higher overlap. We found that locations with higher temperatures and increased drought stress were linked to lower tick abundances, though the magnitude of these effects depended on regional location.
Conclusion
Our study, which compiled 10 years of data, reveals significant regional variation in juvenile I. pacificus phenology across California, including differences in the abundance, peak timing, and temporal overlap. These findings highlight the influence of local climate on tick seasonality, with implications for tick-borne disease dynamics in a changing climate.
Volume of North Pacific Eastern Subtropical Mode Water as a Precursor to ENSO Events
Authors: Liu LingLing , Yu Jin-Yi , Wang Fan , Wang Jianing , Lin YongFu 
Published: December 2024

Abstract

Mode waters play a crucial role in ocean heat and carbon storage, as well as in climate variability. Here we reveal a strong relationship between the North Pacific Eastern Subtropical Mode Water (NPESTMW) and El Niño-Southern Oscillation (ENSO) events. NPESTMW volume anomalies exhibit significant correlations with Ocean Niño Index up to nine months in advance. This relationship is driven by two distinct mechanisms. First, NPESTMW acts as a footprint of another ENSO precursor — the Pacific Meridional Mode — thereby indirectly linking to ENSO occurrence. Second, NPESTMW influences tropical Pacific sea surface temperature through the Subtropical Cell, creating a direct link to ENSO. Moreover, we find that stronger NPESTMW volume anomalies are more closely tied to multi-year ENSO events than to single-year occurrences, especially for the La Niña phase. These findings offer new insights into the roles of subtropical mode water in shaping both ENSO occurrence and its multi-year behavior.
An ancient and still ongoing genetic conflict between transposable elements and their repressors
Authors: Cagliani Rachele , Forni Diego , Mozzi Alessandra , Sarama Roudin , Pozzoli Uberto , Fumagalli Matteo , Sironi Manuela 
Published: December 2024

Abstract

Background. Transposable element (TE) mobilization poses a significant fitness challenge to host genomes. Consequently, a variety of systems have emerged to silence TE activity. Just like TEs, such systems are widespread across the tree of life and their evolution is expected to be shaped by intra-genomic conflicts. To test this hypothesis, we performed an evolutionary analysis of TE control systems across different timescales. Results. We show that a substantial fraction of TE control genes were targets of positive selection during primate evolution, as well as during the more recent history of human populations, with abundant signatures in proteins of the piRNA pathway. In these proteins, selection was strongest in intrinsically disordered regions (IDRs), particularly those with low conformational entropy, and contributed to modulate ensemble features and sequence patterning. In primates, positive selection in a larger number of genes that silence TEs also resulted in reduced accumulation of new mobile elements, as assessed by genomic analysis or recent TE occurrences. Across longer evolutionary time frames, we uncover wide variability in the genomic content of PIWI-containing proteins and an unprecedented diversity of domain architectures for such proteins in eukaryotes. Finally, we identify a bacterial Argonaute as the closest prokaryotic relative of human Argonaute proteins, and we show unusual conservation of IDR sequence and ensemble features across huge evolutionary distances. Conclusions. Our data provide insight into the evolution and diversity of TE control systems in eukaryotes and, through analyses over deep evolutionary distances, contribute information to the rapidly growing evo-immuno discipline.
HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis
Authors: Liu Dan , Lin Shanshan , Hu Yueben , Xiong Jianyong , Wan Hongtao , Chen Yanglin , Ding Taohui , Zhao Hu , Jiang Renjie , Huang Zhijiang , Yao Dengke , Li Ming , Zhu Xiaojian , Yi Bo 
Published: December 2024

Abstract

Ferroptosis, an apoptosis-independent cell death pathway characterized by heightened lipid peroxidation, which holds promise for tumor suppression. Despite extensive research on long non-coding RNAs (LncRNAs) in ferroptosis, their role in colorectal cancer (CRC) remains underexplored. We investigated the upregulation of AC145207.5 and HNRNPC expression in CRC tissues through public dataset analysis and in-house validation, identifying them as having significant diagnostic potential. In vitro experiments including MTS assay, transwell, and colony formation, alongside in vivo studies using xenograft models, elucidated the synergistic carcinogenic role of the HNRNPC/AC145207.5 axis in promoting malignant characteristics of CRC. Mechanistically, the m6A reader HNRNPC stabilized m6A-modified AC145207.5, contributing to its stabilization and upregulation. Consequently, AC145207.5 activated the Nrf2/GPX4 axis, resulting in increased GPX4 expression, inhibition of GPX4-mediated ferroptosis, and facilitation of CRC progression. Our findings underscore the clinical relevance of the HNRNPC/AC145207.5 axis in CRC and illuminate its regulatory role in ferroptosis, suggesting implications for targeted precision medicine in CRC.
A Two direction transmission system by using DQPSK-based WDM Technique Concerning various Launch power values.
Authors: bdulwahid Maan M. 
Published: December 2024

Abstract

This paper investigates the design and performance analysis of optical transmission systems based on differential phase shift keying (DPSK). The OptiSystem software created a comprehensive framework for maximizing transmission performance over long distances. In this work, a Non-Return-To-Zero (NRZ) coded High Data Rate (HDR) system with Erbium-Doped Fiber Amplifiers (EDFAs) and Dispersion Compensating Fibers (DCFs) is transmitted at 40 Gbps for long-distance transmission. Since DPSK modulators are more resilient to noise, fiber degradation, and chromatic Dispersion, they are typically utilized by high-speed optical networks for long-distance transmission. Bit Error Rate (BER) and Q-factor (QF) metrics were used to evaluate the transmission's performance and quality against a range of input power levels (1 mW, two mW, four mW, and six mW) for transmission lengths ranging from 60 km to 360 km. System performance and input power are related outcomes where signal strength loss and performance are compromised. However, signal quality deteriorates beyond the 180 km transmission distance due to nonlinear effects (self-phase modulation, seen here) that heavily rely on the transmission power level. Therefore, input power and distance transmission are two key factors that we should balance to ensure the quality of signal information. The optimal input power for distances below 180 km is four mW; beyond this distance, the performance degrades sharply. This study offers valuable perspectives on the power-distance vs signal quality trade-off in a DPSK-based optical system. Additionally, it addresses the issue of signal integrity over long-distance optical links and provides implementation guidance for reliable optical networks.
Impaired Cerebrospinal Fluid Lipoprotein-Mediated Cholesterol Delivery to Neurons in Alzheimer's Disease
Authors: Borràs Carla , Canyelles Marina , Santos David , Rotllan Noemí , Núñez Estefanía , Vázquez Jesús , Maspoch Daniel , Cano-Sarabia Mary , Carmona-Iragui Maria , Sirisi Sònia , Lleó Alberto , Fortea Juan , Alcolea Daniel , Blanco-Vaca Francisco , Escolà-Gil Joan Carles , Tondo Mireia 
Published: December 2024

Abstract

In the central nervous system, apolipoprotein (APO) E-containing high-density lipoprotein (HDL)-like particles mediate the transport of glial-derived cholesterol to neurons, which is essential for neuronal membrane remodeling and maintenance of the myelin sheath. Despite this, the role of HDL-like cholesterol trafficking on Alzheimer’s disease (AD) pathogenesis remains poorly understood. We aimed to examine cholesterol transport via HDL-like particles in cerebrospinal fluid (CSF) of AD patients compared to control individuals. Additionally, we explored the ability of reconstituted HDL containing different APOE isoforms to regulate cholesterol transport. We evaluated the capacity of CSF HDL-like particles to facilitate radiolabeled unesterified cholesterol efflux from A172 human glioblastoma astrocytes and to deliver cholesterol to SH-SY5Y human neuronal cells. The HDL-like proteome in the AD and control groups was analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Reconstituted HDL nanoparticles were prepared by combining phospholipids and cholesterol with human APOE3 or APOE4, followed by radiolabeling with unesterified cholesterol. Our results showed that cholesterol efflux from astrocytes to CSF were similar between AD patients and controls, both under baseline conditions and after activation of ATP-binding cassette transporters A1 and G1. However, CSF HDL-like particle-mediated neuronal cholesterol uptake was significantly reduced in the AD group. LC-MS/MS analysis identified 775 proteins associated with HDL-like particles in both groups, with no major alterations in proteins linked to cholesterol metabolism. However, 27 proteins involved in non-cholesterol-related processes were differentially expressed. Notably, synthetic reconstituted HDL particles containing APOE4 exhibited reduced capacity to deliver cholesterol to neurons compared to those with APOE3. These findings indicate that CSF HDL-like particles from patients with AD demonstrate impaired cholesterol delivery to neurons. Our study highlights APOE4 as a critical contributor to abnormal neuronal cholesterol uptake in AD pathophysiology.
Evaluation of flocculation performance for Pb2+ and Zn2+ removal from wastewater using the Pseudomonas sp. PR1 flocculant by response surface methodology
Authors: Lu Yanqin , Huang Zilan , Wang Yanwu , Pei Runquan , Xu Liwei , Chen Wenwen , Huang Huanfang , Zeng Honghu 
Published: December 2024

ABSTRACT

To improve the performance of bioflocculant (PR1) in treating lead–zinc wastewater, response surface methodology (RSM), based on central composite design (CCD), was used to optimize the preparation process of bioflocculants for the treatment. The study investigated the impact of different factors, including temperature, pH, and time, on the preparation of PR1, which was further evaluated by a quadratic polynomial equation for the removal efficiency of lead–zinc in wastewater. The removal efficiency of Pb2+ by PR1 was 99.27% at the optimal conditions of temperature (35.53 °C), pH (10), and time (35.13 h). This was consistent with the RSM predictive value of 99.32% with a small deviation (0.05%) by the quadratic model (R2 = 0.9776 and Radj2 = 0.9575). The removal efficiency of Zn2+ by PR1 was 92.98% at optimal conditions of temperature (44.13 °C), pH (8.88), and time (28.27 h). This was in line with the RSM predictive value of 93.19% with a small deviation (0.21%) by the quadratic model (R2 = 0.9773 and Radj2 = 0.9568). The flocculation mechanisms of PR1 are mainly attributed to the electric neutralization and adsorption bridging. Together, PR1, optimized by RSM, was a highly efficient and promising bioflocculant for removing Pb2+ and Zn2+ from industrial wastewater.
PRÁTICAS PEDAGÓGICAS ASSOCIADAS A INFECÇÃO URINÁRIA EM GESTANTES NOS SERVIÇOS DE SAÚDE: REVISÃO INTEGRATIVA
Authors: Caldas Naylane de Farias , Furtado Rosalina  de Paula , Cavalcante Gardênia da Silva , Oliveira Beatriz Nascimento Marinho de , Borba-Pinheiro Claudio Joaquim 
Published: December 2024

Introdução: a patologia de Infecção do Trato Urinário (ITU) é causada pela presença de microrganismos patogênicos na urina, e na gravidez, as mudanças anatômicas e fisiológicas impostas ao trato urinário predispõem as mulheres a transformações, que as tornam suscetíveis a infecções bacterianas. Objetivo: analisar possíveis práticas educativas voltada para gestantes com infecção urinária atendidas nos serviços de saúde. Metodologia: foi realizado um estudo de revisão guarda-chuva nas seguintes bases de dados: BVS, Pubmed, Scielo, Lilacs e Google acadêmico, usando os seguintes descritores: infecção urinária, educação em saúde, saúde da mulher, atenção integral à saúde da mulher, atenção básica. Seguindo também o modelo PRISMA que determinou a pergunta norteadora: quais são as práticas pedagógicas que influenciam na redução de infecções urinárias nas gestantes? Resultados: foram encontrados 6 artigos de revisão, onde: 4 são integrativas e 2 são sistemáticas, destes, 5 estudos abordaram o objetivo deste estudo de forma superficial e um de forma específica. Conclusões: O presente estudo conclui que existem poucas pesquisas qualificados na literatura sobre ações educativas voltadas para gestantes com infecção urinária.