bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apprendre à animer un cercle pédagogique : préoccupations de conseiller⋅ère⋅s pédagogiques
Authors: Giguère Marie-Hélène 
Published: October 2021

Les conseiller⋅ère⋅s pédagogiques sont de plus en plus appelé⋅e⋅s à accompagner et non plus à simplement former le personnel enseignant dans la transformation de leurs pratiques pédagogiques. Or, très peu de dispositifs d’accompagnement visant le développement professionnel des conseiller⋅ère⋅s pédagogiques sont documentés. Cette recherche collaborative décrit les préoccupations d’une équipe de conseiller⋅ère⋅s pédagogiques s’appropriant l’animation d’un cercle pédagogique, un dispositif de développement professionnel. Sept rencontres d’échange et un entretien collectif ont été menés. Des analyses thématiques de contenu ont permis de dégager huit sous-dimensions auxquelles les conseiller⋅ère⋅s pédagogiques ont accordé de l’importance. Les résultats indiquent que des aspects organisationnels y tiennent une grande place, mais ont aussi un impact sur leur identité professionnelle.
Entre croyances et pratiques de futurs enseignants de mathématiques au secondaire : une relation perméable
Authors: Hanin Vanessa , Laurent Anaïs , Van Nieuwenhoven Catherine 
Published: October 2021

La stabilité des résultats faibles des élèves en mathématiques préoccupe depuis bon nombre d’années les systèmes éducatifs à travers le monde. Si les pratiques pédagogiques enseignantes sont pointées comme un facteur déterminant de l’engagement des élèves et de la qualité de leurs apprentissages, elles ne représentent que la partie émergée de l’iceberg. Beaucoup de travaux ont montré que ces pratiques sont fortement colorées tant par les croyances épistémologiques que par les croyances relatives à l’enseignement et à l’apprentissage des disciplines.Àce sujet, si certaines recherches rapportent une influence péremptoire des croyances sur les pratiques enseignantes, d’autres présentent des résultats plus modérés en soulignant, par exemple, la perméabilité des croyances à la formation initiale. S’appuyant sur les résultats d’une étude quantitative ayant identifié trois profils de croyances (pro-traditionnel, anti-traditionnel, flexible) chez 190 futurs enseignants de mathématiques au secondaire, en dernière année de formation, cette contribution vise à éclairer qualitativement l’articulation entre les croyances et les pratiques pédagogiques de onze d’entre eux. L’analyse des entretiens fait ressortir la nature conciliable des conceptions transmissives et constructivistes de l’enseignement-apprentissage. En outre, la présence de pratiques pédagogiques similaires, soutenues en formation, au sein de profils aux croyances contrastées plaide en faveur d’une non-linéarité croyances-pratiques.
Some Aspects of Using Clinoptilolite in Calves Feeding
Authors: Zelenchenkova Alyona Anatolyevna , Nekrasov Roman Vladimirovich , Chabaev Magomed Gazievich , Ostrenko Konstantin Sergeevich 
Published: October 2021

The use of clinoptilolite is an effective means of increasing the gain and live weight of calves. The application does not cause difficulties in the methods of introducing the additive to calves. Natural clinoptilolites of various deposits are presented in a wide range on the feed additives market.
Aims: The objective of the work was to study the effectiveness of natural mineral clinoptilolite on physiological and zootechnical indicators of growth and development of calves.
Methodology: The study was carried out on 39 clinically healthy Holsteinized black-and-white calves selected at random, 13 animals per group. For 85 days, the calves of the experimental group received a basic diet enriched with natural mineral clinoptilolite to increase the efficiency of growth and development at a dosage of 25-50 and 50-100 g / head / day. Blood samples were taken from the jugular vein at the end of the supplement feeding (n = 5) for physiological, biochemical and immunological studies.
Results: In the course of the study, it was found that in the experimental groups there were higher gains in live weight by 7.3 and 4.7% in comparison the control, and low feed costs per 1 kg of gain. Feeding clinoptilolite promoted an increase in the concentration of Ca in the blood of calves of the dairy period by 14.2% (p <0.05), an increase in phagocytic activity by 4.87 (p <0.05), the phagocytic number was higher by 0.20 (p < 0.05) units.
Conclusion: The totality of the information presented confirms the physiological adequacy for calves to the introduction of natural mineral clinoptilolite in the indicated dosages.
Pharmaceutical Standardization and Drug Dosage Modification of Laghu Sudarshan Churna with Comparative Assessment of its Antipyretic and Analgesic Activities in Albino Rats
Authors: Chunchuwar Manasi D. , Rathi Bharat , Wanjari Anita , Rathi Renu 
Published: October 2021

Introduction: Laghu Sudarshan Churna is a Churna mentioned by Yogratnakar indicated in the treatment of all types of Jwara and its action is Tridoshanashak. Fever is bodys natural defense mechanism against infectious agents which can damage the tissue. Some studies have suggested that raising temperature may be harmful. Therefore, in clinical practices in which fever associated risk benefits, antipyretic treatment is necessary.
Aim and Objective: Drug dosage modification and pharmaceutical standardization of Laghu Sudarshana Churna to Laghu Sudarshana Vati with comparative Assessment of its Antipyretic & Analgesic activities in albino rats.
Materials and Methods: To evaluate antipyretic & analgesic activities of test drugs the most commonly employed method to induce fever in animals is brewers yeast induced pyrexia, Tail flick test & Hot plate test for analgesic in animal models.
Observation and Results: Observation will be done on the basis of Physicochemical & Organoleptic characteristics of Laghu Sudarshan churna & Laghu Sudarshan vati. Results will be drawn on the basis of observations & applying suitable test. It will be noted & presented in the form of table, charts & graphs etc.
Conclusion: If this Antipyretic & Analgesic study is successful then this data will be used in another clinical study for intervention of Antipyretic & Analgesic studies, as it is Herbal medicine so it will show no any toxic effect in animal models. Hence, it will be easily used in humans also.
Private-Sector Readmissions for Inpatient Surgery in Veterans Health Administration Hospitals
Authors: Vaughan Sarrazin Mary , Gao Yubo , Jacobs Carly A. , Jacobs Michael A. , Schmidt Susanne , Davila Heather , Hadlandsmyth Katherine , Strayer Andrea L. , Cashy John , Wehby George , Shireman Paula K. , Hall Daniel E. 
Published: December 2024

ImportanceThe Veterans Health Administration (VHA) reports multiple indicators of hospital surgical performance, including hospital risk-standardized 30-day readmission rates (RSRRs). Currently, most routinely reported measures do not include readmissions that occur outside VHA hospitals. The impact of readmissions outside the VHA on hospital RSRR is not known.ObjectiveTo measure the impact of including non-VHA readmissions on VHA hospital performance rankings for 30-day readmission.Design, Setting, and ParticipantsThis retrospective cohort study included patients aged at least 65 years from 2013 to 2019 from the Veterans Affairs Surgical Quality Improvement Program linked to patient-level data from the VHA and Medicare. Data were limited to patients with VHA and Medicare enrollment during the year prior to surgery. Data were analyzed from November 2023 through July 2024.Main Outcomes and MeasuresThe main outcome was readmissions to acute care VHA or non-VHA hospitals within 30 days of discharge. VHA hospital–level RSRRs were estimated using separate generalized linear mixed-effects risk adjustment models that alternatively included VHA-only or VHA plus non-VHA readmissions. VHA hospitals were then stratified into quintiles based on RSRRs derived using VHA-only or VHA plus non-VHA readmissions. Changes in hospital performance quintiles with the addition of non-VHA readmissions were calculated, and characteristics of VHA hospitals most impacted by including non-VHA readmissions were evaluated.ResultsThe eligible cohort included 108 265 patients (mean [SD] age, 72.2 [6.5] years; 105 661 [97.6%] male) who underwent surgery in 104 VHA hospitals. The combined readmission rate was 14.0%. The proportion of readmissions occurring outside the VHA ranged from 0% to 55.3% across the 104 VHA hospitals (median, 20.9%). Using VHA and non-VHA readmissions, 24 VHA hospitals (23.1%) improved performance and 23 hospitals (22.1%) worsened performance, defined as a decrease or increase, respectively, of 1 or more RSRR quintiles. Improvements in hospital performance rank were associated with larger surgical volume (−7.48; 95% CI, −11.33 to 03.64; P &amp;lt; .001), urban location, greater surgical complexity (−9.86; 95% CI, −16.61 to −3.11; P = .005), and lower proportion of readmissions outside the VHA (−8.15; 95% CI, −12.75 to −3.55; P &amp;lt; .001).Conclusions and RelevanceIn this cohort study, VHA hospitals whose readmission performance metric improved by including non-VHA readmissions had higher patient volume, higher complexity, and lower proportion of care outside the VHA. Thus, improving continuity of care may have a paradoxical effect of worsening VHA performance metrics.
Sociodemographic Factors and Utilization of Pediatric Oncology Satellite Clinics in Ontario, Canada
Authors: Chiu Maria , Ali Abbas , Leung Felicia , Dong Chaoran , Pechlivanoglou Petros , Hodgson David , Gibson Paul 
Published: December 2024

ImportancePediatric cancer care services in high-income nations are mainly centralized in metropolitan cities. To allow treatments closer to home, patients across Ontario, Canada, a geographically large province, are offered decentralized care via satellite clinics; however, it is unclear whether the utilization of these pediatric oncology satellite clinics differs by area-level sociodemographic factors.ObjectiveTo examine whether sociodemographic factors, such as area-level income and rurality, are independently associated with the odds of satellite clinic visit and the hazards of time to first visit among pediatric oncology patients receiving cancer treatment.Design, Setting, and ParticipantsThis is a retrospective population-based cohort study of patients aged 0 to 17 years with cancer living in a satellite catchment area in Ontario, Canada (from 2015 to 2022, with follow-up through 2023). The Pediatric Oncology Group of Ontario Networked Information System cancer registry (containing age, sex, diagnosis type, and year information) was linked to satellite, OpenStreetMap, and postal-code databases to ascertain rural or urban dwelling, neighborhood-based income, and driving time saved.ExposuresAge, sex, rural or urban dwelling, and neighborhood-level income quintiles.Main Outcomes and MeasuresThe primary outcomes were the odds of satellite clinic attendance within 1 year of diagnosis and the hazards of first clinic visit after starting systemic therapy, derived from multivariable logistic and Cox proportional hazards models, respectively.ResultsAmong the 1280 eligible patients (median [IQR] age, 7.0 [3.0-13.0] years; 753 male [58.8%]), 844 (65.9%) visited a satellite clinic within 1 year of diagnosis with a median (IQR) of 39 (14-67) days to first visit. Driving time saved (&amp;gt;60 minutes) was the factor most associated with satellite use, followed by diagnostic type (with patients with central nervous system tumors least likely to visit). Rural (vs urban) patients had significantly lower odds of satellite visit within a year of diagnosis (odds ratio, 0.48; 95% CI, 0.31-0.74; P = .001) and lower instantaneous likelihood of visiting after start of treatment (hazard ratio, 0.65; 95% CI, 0.53-0.81; P &amp;lt; .001). Living in a lower-income (vs middle-income) area was also associated with significantly lower utilization (odds ratio, 0.53; 95% CI, 0.35-0.80; P = .009; hazard ratio, 0.73; 95% CI, 0.60-0.89; P = .002).Conclusions and RelevanceThis population-based study of pediatric oncology patients found that satellite clinics, despite being designed to reduce transportation and financial burdens, were disproportionately underutilized by patients living in rural and lower-income areas. Monitoring area-level social determinants of health can help inform interventions to improve timely and equitable access to childhood cancer care closer to home.
Selective Photocatalysis of Benzyl Alcohol Valorization by Cocatalyst Engineering Over Zn2In2S5 Nanosheets
Authors: Wang Ran , Shi Li , Konysheva Elena Yu. , Xu Xiaoxiang 
Published: December 2024

AbstractPhotocatalytic conversion of benzyl alcohol (BA) is a promising means to coproduce H2 with value‐added chemicals. However, there is a lack of an efficient strategy to regulate the selectivity of the BA conversion products. Here, by a simple cocatalyst engineering technique, the selective conversion of BA over Zn2In2S5 nanosheets (ZIS) is maneuvered. Two types of cocatalysts, i.e., Pt and Cd, are photo‐deposited onto ZIS that can shift the selectivity to diverse products, namely, Pt to benzaldehyde (BAD) and Cd to the carbon‐carbon (C─C) coupling compounds. Mechanistic studies indicate that Cd has a high reducing capacity to convert BAD back to the ketyl radical (C𝛼 radical), favoring the construction of the C─C bonds. Pt, however, facilitates the generation of C𝛼 radicals but is energetically unfavorable for their coupling reactions, resulting in the generation of BAD as the main product. Theoretical calculation reveals that the distinct catalytic behaviors of Pt and Cd stem from their different electronic structures that govern the adsorption strength to the reaction intermediates and the reaction energy barriers of the C─C coupling step. This work not only addresses the challenge of selectivity regulation for BA conversion but also brings fresh mechanistic insights into the role of the cocatalysts.
Flaky Li‐Doped High‐Entropy Oxide Enables PEO‐Based Composite Solid Electrolyte with Extended Suitability for Lithium Metal Batteries
Authors: Liu Weijie , Liu Jiaxing , Yang Zhihao , Liu Meiling , Sang Shangbin , Liu Hongtao 
Published: December 2024

AbstractPoly(ethylene oxide) (PEO) as a solid‐state electrolyte faces critical limitations, including low ionic conductivity, a narrow electrochemical window, and poor mechanical strength. To address these issues, flaky lithium‐doped high‐entropy oxides (LHEO‐f) with abundant surface oxygen vacancies are synthesized via a facile microwave‐assisted deep eutectic solvent (DES) method and incorporated into PEO‐based composite solid electrolytes (CSEs). The flaky LHEO‐f fillers morphology increases the continuous contact surface area with polymer chains, while oxygen vacancies enhance interfacial interactions. This synergy diminishes polymer deformation and enhances the mechanical strength of the CSEs. Moreover, the surface defects of LHEO‐f improve interactions with the oxygen‐containing groups of the polymer matrix, facilitating Li‐ion migration. All‐solid‐state lithium metal batteries (ASSLMBs) with these CSEs demonstrate excellent high‐rate capacity and cycling stability. These findings reveal that the incorporation of LHEO‐f significantly bolsters the performance of PEO‐based CSEs, showcasing their potential for further advancement and practical application in the realm of solid‐state batteries.
Solvent‐Induced Polyelectrolyte Conjugation for Fluorescence‐Dependence Solvent Detection
Authors: Shi Yueqin , Shao Jiawei , Wang Jianxiang , Guo Rui , Li Zhengjun , Li Ning , Zhang Qi , Chu Liang 
Published: December 2024

AbstractSolvated assembly and fluorescence are two distinct features of conjugated polyelectrolytes for remarkable optoelectronic properties. However, the essential correlation between solvated assembly and fluorescence properties is still undiscovered. Here, two homopolymers based on benzotriazole (BTz) backbones with pyridinium cation‐pendants (PBTz‐PyrBr) and quaternary amine cation‐pendants (PBTz‐TMABr) are designed to distinguish fluorescence response in polar solvents, which evokes a novel application in fluorescence‐dependence solvent detection. The conjugated backbones offer orderly aligned electron‐rich nitrogen atoms to chemically react with the quaternary amine cation‐pendants for creating a space conjugation, serving as a fluorescence sensing site in polar solvents. In low‐polarity solvents, conjugated chains tend to twist and aggregate, accompanied by the space‐conjugation enhancement. This behavior increases the fluorescence performance by suppressing both inter‐ and intra‐molecular charge transfer. Furthermore, a theoretical linear‐correlation is established between fluorescence and solvent polarity/concentration to elucidate the experimental rule, giving a robust opportunity for solvent detection.
Sub‐Nanometer Porous Carbon Materials for High‐Performance Supercapacitors Using Carbon Dots as Self‐templated Pore‐Makers
Authors: Zhang Xi‐Rong , Song Tian‐Bing , He Tian‐Le , Ma Qian‐Li , Wu Zhao‐Fan , Wang Yong‐Gang , Xiong Huan‐Ming 
Published: December 2024

AbstractCustomizable porous carbon structures are critical for high‐performance electrode materials, and the modulation of the pore parameters at different levels remains a great challenge. For supercapacitors, the preferred carbon materials should own high specific capacitance, nice rate performance, large density, low self‐discharge, and high mass‐loading, which could be accomplished by sub‐nanometer pores (0.5–1.0 nm). Herein, a new method of using carbon dots (CDs) as self‐templates is reported to produce porous carbon with uniform pore diameters of 0.64–0.80 nm. As a result, the optimal sample with a high packing density (0.81 g cm−3) displays outstanding capacitances (gravimetric 515.5 F g−1, areal 5.16 F cm−2, and volumetric 417.6 F cm−3 respectively at 1 A g−1) at the commercial‐level mass‐loading of 10 mg cm−2. The assembled high‐loading symmetric supercapacitor shows a high energy density of 22.3 Wh kg−1 at 3500 W kg−1, as well as a long cycle stability (99.9% of retention rate after 10 000 cycles at 2 A g−1) in an ultrawide voltage range of 1.4 V with aqueous electrolytes. This work suggests a micropore‐forming strategy for the preferred porous carbon, which can be applied in supercapacitors, batteries, filters, adsorbents, and catalysts.
Vacancy Engineering on MnSe Cathode Enables High‐Rate and Stable Zinc‐Ion Storage
Authors: Zhong Wenping , Zhao Rui , Zhu Yirong , Xu Yuting , Chen Wenhao , Peng Chao 
Published: December 2024

AbstractManganese selenide (MnSe), as a newly emerged manganese‐based chalcogenide, has recently been considered as a potential cathode for aqueous Zn‐based energy storage due to its many merits. Nevertheless, its unsatisfactory kinetic performance and cycling stability, along with its controversial energy storage mechanism, hinder its commercial application. Herein, the MnSe microspheres with Se‐rich vacancies (VSe‐MnSe) are synthesized, and employed as a cathode for Zn‐ion batteries/capacitors (ZIBs/ZICs) for the first time. Density functional theory (DFT) calculations and kinetic analyses illustrate that vacancy engineering of MnSe enhances the active sites, improves the electronic conductivity and ion transport, and reduces the adsorption energy and diffusion energy barriers of H+ and Zn2+, endowing the VSe‐MnSe cathode of ZIBs with significantly enhanced specific capacity, rate capability, and cycling stability. Interestingly, ex situ tests confirm the stable existence of VSe‐MnSe during the whole charge/discharge process and store energy with the first H+ insertion and subsequent H+/Zn2+ co‐insertion. More encouragingly, the VSe‐MnSe//porous carbon (PC) ZICs exhibit an ultrahigh energy density (178.0 Wh kg−1), a high power density (10 kW kg−1), and eminent cyclic stability (up to 10000 cycles). This research offers an efficient strategy for designing and developing high‐performance manganese‐based chalcogenides and sheds new insights into their energy storage mechanisms.
A Three‐In‐One Heptamethine Cyanine Dye Induces Endoplasmic Reticulum Stress and Apoptosis in Colorectal Cancer
Authors: Park Yoonbin , Yang Juhui , Kim Moon Suk , Hyun Hoon 
Published: December 2024

AbstractOne of the most significant challenges for image‐guided cancer‐targeted therapy is to develop multifunctional optical contrast agents enabling simultaneous targeting and therapy. Herein, a feasible strategy is based on the incorporation of therapeutic moieties into the non‐delocalized structure of polymethine indocyanines, known as the “structure‐inherent targeting” concept. By possessing a rigid chloro‐cyclohexenyl ring in the heptamethine cyanine backbone, a new type of multifunctional near‐infrared fluorescent dye, Ph790H, that targets tumor without the need for additional targeting ligands is synthesized. Armed with a phthalimide pharmacophore holding a prominent position in medicinal chemistry, Ph790H simultaneously induces endoplasmic reticulum (ER) stress to exert targeted therapeutic effects on HT‐29 colorectal cancer xenografts. In terms of molecular mechanism, the lipophilic cationic Ph790H can be actively internalized into HT‐29 cells through clathrin‐mediated endocytosis. Consequently, mitochondrial reactive oxygen species (ROS) overproduction further induces activation of ER stress, demonstrated by increased ROS concentration and decreased mitochondrial membrane potential, which contributes to cell apoptosis and inhibition of tumor growth. Overall, Ph790H represents an effective “three‐in‐one” agent for the integration of cancer targeting, imaging, and therapy, which may provide a practical strategy to develop multifunctional small molecule theranostic agents for simultaneous cancer diagnosis and therapy.
4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea
Authors: Chiesa Irene , Esposito Alessio , Vozzi Giovanni , Gottardi Riccardo , De Maria Carmelo 
Published: December 2024

Abstract4D bioprinting is a cutting‐edge approach for manufacturing active scaffolds able to shape‐morph in a predefined way after the application of an environmental stimulus, thus enabling to mimic the dynamics of native tissues. This study develops a self‐folding gelatin‐based bilayer scaffold for trachea engineering exploiting the 4D bioprinting approach. Starting from a 2D flat configuration, upon hydration, the scaffold automatically forms a closed tubular structure. An analytical model, based on Timoshenko's beam thermostats, is developed and validated to predict the radius of curvature of the scaffold. The 4D bioprinted structure is tested with airway fibroblast, lung endothelial cells, and cartilage progenitor cells (CPCs) toward the development of a tissue‐engineered trachea. Cells are seeded on the scaffold in its initial flat configuration, maintain their position after the scaffold actuation, and proliferate over or inside it. The ability of CPCs to differentiate toward mature cartilage is evaluated. Interestingly, real‐time PCR reveals that differentiating CPCs on the 4D bioprinted scaffold promotes healthier cartilage formation, if compared with CPCs cultured on 2D static flat scaffold. Thus, CPCs can perceive scaffold folding and its final curvature and react to it, toward the formation of mature cartilage for the airway.