bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex Picture Fuzzy N-Soft Sets and Their Decision Making Algorithm
Authors: Mahmood Tahir , Rehman Ubaid ur , Ahmmad Jabbar 
Published: May 2021

Abstract
We establish in this manuscript a new model complex picture fuzzy N-soft sets (CPFN-SSs) which is the fusion of complex picture fuzzy sets (CPFSs) along with N-soft sets (N-SSs) and a novel definition of CPFSs which is a mixture of complex fuzzy sets (CFSs) and picture fuzzy sets (PFSs). In CPFN-SS notions of N-SSs, fuzzy N-SSs (FN-SSs), intuitionistic FN-SSs (IFN-SSs), picture FN-SSs (PFN-SSs) complex FN-SSs (CFN-SS), complex IFN-SSs (CIFN-SSs) are generalized. We also talk about few basic operations on CPFN-SSs with the assistance of examples. Additionally, we establish two kinds of union (extended and restricted) and intersection (extended and restricted) of CPFN-SSs and illustrate them through examples. We also establish a complement of CPFN-SSs along with an example. Furthermore, we define an algorithm to solve the data in the environment of CPFN-SSs, and then we represent two real-world applications (performance assessment of e-waste recycling program and predication about the champions of FIFA world cup 2022 through audience poll) of our established model in decision-making (DM) to show the advantages and usefulness of the CPFN-SSs. In the end, we represent a comparison of our established model with some existing methods which shows that our established model is more general than existing ones.
The aesthetic evaluation of forest landscape in four urban forest parks: A case study of Nanjing hilly areas, China
Authors: Yang Yang , Tang Xiaolan 
Published: May 2021

Abstract
In recent years, the construction of urban forest parks has run into the fast lane in China. As an indispensable natural landscape resource for urban forest parks, forest landscape has been paid increasing attentions by the public, in contrast, less effort has been made in the field of aesthetic evaluation of forest landscape. Based on the theories of landscape esthetics and psychology, this paper aims to present methods for the aesthetic evaluation, and understand citizen’s aesthetic perceptions of forest landscape using Semantic Differential (SD) and Principal Component Analysis (PCA) methods. Moreover, further suggestions will be put forward for a better development of the forest landscape, thereby giving full play to their landscape and recreation functions. As per the findings of this paper, the vegetation element diversity (PC 1 ), the magnificent feel (PC 2 ), the nature-pastoral feel (PC 3 ) and the sense of space (PC 4 ) present the critical comprehensive indexes affecting the aesthetic values of the forest landscape. The relationship between the comprehensive indexes and the landscape aesthetic value is revealed by multiple regression analyses. PC 3 and PC 4 are found to be less influencing on aesthetic values than PC 1 and PC 2 . At last, three suggestions for the construction and protection of forest landscape are put forward. The results of this study will contribute to the preservation of the forest landscape aesthetic, and the integration of these conclusions into the sustainable development strategies of urban forest parks.
Upstream region of OprD mutations in imipenem-resistant and imipenem-sensitive Pseudomonas aeruginosa isolates
Authors: Kiani Masoumeh , Astani Akram , Khozani Nahid Rezaei , Khaledi Mansoor , Afkhami Hamed , Rostami Soodabeh , Zarei Mohadeseh , Zandi Hengameh 
Published: May 2021

Abstract
The current study was aimed at investigating the prevalence of the mutations upstream of the oprD coding region and its promoters among imipenem-resistant and sensitive Pseudomonas aeruginosa isolated from educational hospitals in Yazd City, Iran. All isolates were identified by the conventional biochemical tests. Then, the antibiotic resistance of these isolates was determined using the disk diffusion method according to the CLSI guidelines. Also, the E.test was performed to determine the minimum inhibitory concentrations (MIC) of imipenem. The mutations of this gene were recognized by the amplification of this region and subsequently sequenced. Sequencing of the genomic region upstream of oprD these regions were done in the 29 clinical strains. Statistical analysis was done by the statistical software SPSS-18. Seventy (77.7%) of isolates had MIC ≥ 16 and were resistant to imipenem. Mutations of the upstream of the oprD gene and its promoters were seen in 25 (86.2%) isolates and 4 isolates had no mutation. One isolate had a base substitution A→Cat nt 25 in the coding region and this isolate had a point mutation leading to an amino acid change at positions 9 (I→L). Our study results indicated that none of the strains had mutation in Shine-Dalgarno and the point mutations were the most common mutations upstream of the oprD coding region among P. aeruginosa isolates. Mutations were observed in imipenem-resistant isolates and it seems this mechanism is effective in resistance of isolates to imipenem and this confirmed that the indiscriminate use of antibiotic should be controlled.
Multi-attribute group decision-making method based on weighted partitioned Maclaurin symmetric mean operator and a novel score function under neutrosophic cubic environment
Authors: Fan Jianping , Zhai Shanshan , Wu Meiqin 
Published: May 2021

Abstract
Neutrosophic cubic set (NCS) is the generalized version of neutrosophic sets and interval neutrosophic sets. It can deal with the complex information by combining the neutrosophic set (NS) and cubic set (CS). The partitioned Maclaurin symmetric mean (PMSM) operator can reflect the interrelationships among attributes where there are interrelationships among attributes in the same partition, but the attributes in different partitions are irrelevant. To effectively gather neutrosophic cubic information, we extend the PMSM operator to neutrosophic cubic environment and define the neutrosophic cubic partitioned Maclaurin symmetric mean (NCPMSM) operator and neutrosophic cubic weighted partitioned Maclaurin symmetric mean (NCWPMSM) operator. Later, we define a novel score function of NCS which overcome the drawbacks of the existing score functions. Next, based on NCWPMSM operator and the novel score function, we develop a multi-attribute group decision-making method. Finally, we give an example of supplier selection to illustrate the usefulness of the proposed multi-attribute group decision-making (MAGDM) method. At the same time, a comparative analysis is to show the effectiveness and advantages of the proposed method compared with the existing methods
RNA-sequencing reveals the expression profiles of tsRNAs and their potential carcinogenic role in cholangiocarcinoma
Authors: Yan Li-rong , Wang Ang , Xu Qian , Wang Ben-gang 
Published: May 2021

Abstract
Background

Recently, the incidence of cholangiocarcinoma (CCA) has gradually increased. As CCA has a poor prognosis, the ideal survival rate is scarce for patients. The abnormal expressed tsRNAs may regulate the progression of a variety of tumors, and tsRNAs is expected to become a new diagnostic biomarker of cancer. However, the expression of tsRNAs is obscure and should be elucidated in CCA.
Methods

High-throughput RNA sequencing technology (RNA-seq) was utilized to determine the overall expression profiles of tsRNAs in 3 pairs CCA and adjacent normal tissues and to screen the tsRNAs that were differentially expressed. The target genes of dysregulated tsRNAs were predicted and the biological effects and potential signaling pathways of these target genes were explored by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate 11 differentially expressed tRFs with 12 pairs CCA and adjacent normal tissues.
Results

High-throughput RNA-seq totally demonstrated 535 dysregulated tsRNAs, of which 241 tsRNAs were upregulated and 294 tsRNAs were downregulated in CCA compared with adjacent normal tissues (|log2 (fold change) |≥1 and P value < 0.05). GO and KEGG enrichment analyses indicated that the target genes of dysregulated tRFs (tRF-34-JJ6RRNLIK898HR, tRF-38-0668K87SERM492V and tRF-39-0668K87SERM492E2) were mainly enriched in the Notch signaling pathway, Hippo signaling pathway, cAMP signaling pathway and in growth hormone synthesis, secretion and action, etc. qRT-PCR result showed that tRF-34-JJ6RRNLIK898HR/tRF-38-0668K87SERM492V/tRF-39-0668K87SERM492E2 was down-regulated (P = 0.021) and tRF-20-LE2WMK81 was up-regulated in CCA (P = 0.033).
Conclusion

Differentially expressed tRFs in CCA are enriched in many pathways associated with neoplasms, which may impact the tumor progression and have potential to be diagnostic biomarkers and therapeutic targets of CCA.
A Prospective, Randomized Controlled Study for the Efficacy and Safety of the Substitution of Pyrazinamide and Ethambutol With Moxifloxacin During the Intensive Phase of Treatment of Pulmonary Tuberculosis
Authors: Shang Yuqi , Liu Xi , Chen Yuanli , Luo Xiaoqing , Zhu Hongqiong , Xia Jinyu , Ding Li 
Published: May 2021

Abstract
Background: Moxifloxacin (MFX, M) is currently a second-line antituberculosis drug as initial therapy of pulmonary tuberculosis and one of the main anti-TB drugs in drug-resistant TB, which can kill both intracellular and extracellular Mycobacterium tuberculosis. We started a trial to study the efficacy and safety of the substitution of pyrazinamide and ethambutol with moxifloxacin during the intensive phase of treatment of newly diagnosed susceptive pulmonary tuberculosis. Methods/design: This is a prospective, open, randomized, parallel-controlled, single-center clinical study. The study consists of three phases: a screening period, a treatment period of 6 (or 7) months, and a follow-up period of 1 year. Patients selected for the study will be allocated to the trial group or the control group randomly. The control group will be given six months of a standard regimen(2HRZE/4HR). The trial group will be given a total of six months of treatment with substitution of pyrazinamide and ethambutol with moxifloxacin during the intensive phase(2HRM/4HR). The primary outcome is the rate of adverse outcomes within one year of completion of therapy. The Secondary outcomes include the rate of treatment success at the 2nd, 3rd, 5th and 6th months, the rate of sputum Mtb(Mycobacterium tuberculosis) negative conversion at the 2nd, 3rd, 5th and 6th months, the time of sputum Mtb negative conversion at the 2nd, 3rd, 5th and 6th months, and the number of patients with adverse events within one year of completion of therapy. Comparisons will be performed using two-sided tests with a statistical significance level of 5%.Discussion: This trial will reveal the effectiveness and safety of 2months of use of moxifloxacin instead of pyrazinamide and ethambutol during the intensive phase of treatment for newly diagnosed susceptive pulmonary tuberculosis. If the new regimen including isoniazid, rifampicin and moxifloxacin during the intensive phase of treatment (2HRM/4HR) is no less effective and safe than the standard regimen(2HRZE/4HR), it could be a new alternative treatment for newly diagnosed susceptive pulmonary tuberculosis in the future. Trial registration: ClinicalTrials.gov, NCT04187469. Registered on 5 December 2019.
Efficacy of conventional fluoridated toothpastes containing arginine and high-fluoride toothpastes on the control of root caries in patients undergone radiotherapy of head-and-neck: a randomized controlled trial
Authors: Velo Marilia , Giacominni Marina , Brianezzi Leticia , Gonçalves Rafael , Zabeu Giovanna , Santos Paulo , Ishikiriama Sergio , Honório Heitor , Wang Linda 
Published: May 2021

Abstract
This parallel, triple-blind RCT evaluated the restorative performance of a resin-modified glass-ionomer-cement (RMGIC) in irradiated patients and the prevention of root caries lesions adjacent to restoration, comparing the effect of conventional (control) concentration, high-fluoride (F) containing fTCP and arginine-based toothpastes. A total of 63 lesions was screened and 60 were included into randomized distribution into three groups (N- participants in baseline/n- root caries lesions): G1 = 1,450 ppm F (N = 10/n = 17); G2 = 5,000 ppm F + fTCP (N = 7/n = 18) and G3 = 1,450 ppm F + arginine + CaCO3 (N = 6/n = 25). Based on eligibility criteria, all patients were mandatory enrolled after completed 3-month of radiotherapy of head-and-neck. Two calibrated operators performed the restorative procedures (RMGIC - Vitremer) and two calibrated examiners (Kappa = 0.94) evaluated the restorations based on modified USPHS criteria at baseline, 1, 3 and 6-month follow-up. Data was collected and statistically assessed with Kruskal-Wallis test (p < 0.05). There were no statistically significance differences among the performance of the restoration among the three groups regarding the criteria retention, marginal adaptation, marginal staining, post-operative sensitivity, adjacent caries, color alteration, anatomic form and surface texture (p > 0.05). Even with oral complications caused by radiation-therapy, if the restorations are properly performed and patients are under professional supervision, high-F presented similar efficacy of arginine and conventional-containing toothpastes to prevent secondary caries. Clinical relevance: This clinical trial brings new evidences about the regular use of high-F, arginine-based and conventional-F containing toothpastes in irradiated patients under supervision of a multidisciplinary team and the encouragement of self-cooperation.
A qualitative study to define meaningful change in physical function after weight-loss.
Authors: Poon Jiat Ling , Marshall Chris , Johnson Chloe , Pegram Hannah , Hunter Maile , Kan Hongjun , Ahmad Nadia 
Published: May 2021

Abstract
Purpose
This study explored perceptions of meaningful weight-loss and the level of change on two patient-reported outcome (PRO) measures, the 36-item Short Form Health Survey® [SF-36v2®] and Impact of Weight on Quality of Life Lite-Clinical Trials © [IWQOL-Lite-CT © ], that individuals living with overweight or obesity consider to be meaningful and indicative of treatment success.
Methods
Thirty-three qualitative interviews were conducted in the US with adults living with overweight or obesity. Concept elicitation explored perceptions of minimally important/meaningful weight-loss using open-ended questions. Cognitive debriefing was used to understand thresholds for meaningful change on both measures.
Results
Most participants (n=23/33) expected a 5% total body weight-loss to yield some benefit in physical functioning, while all participants expected a 10% weight-loss to provide a meaningful and noticeable improvement in their physical functioning.
Participants indicated that an item-level 1-point score change on each measure would represent a noticeable improvement in physical functioning and indicate treatment success.
Conclusions
Participants expected moderate weight losses to be noticeable, with ≥10% weight-loss yielding the most consistent results. The findings suggested that both measures provide strong opportunity to demonstrate treatment benefit in relation to physical functioning as a small change on the response scale would represent a noticeable improvement in participants’ daily lives.
Community Needs Assessment of Ten Rural Villages in Karnataka and Tamil Nadu, India
Authors: Bhuiya Tanzim , Thakker Krima , Hyacinthe Julia , Cioe-Pena Eric 
Published: May 2021

Abstract
Background: India’s health disparities are clearly visible in the southern state of Karnataka. A community needs assessment, one of the first done in this area in over a decade, was conducted to identify unsatisfied needs. The Northwell Center for Global Health worked alongside a local boarding school, Shanti Bhavan, to conduct a needs assessment using the Center for Disease Control and Prevention’s Community Assessment for Public Health Emergency Response tool. Methods: A community based cross-sectional survey design was implemented in ten rural villages in Karnataka throughout February 2019. The target population for this study included people that earned less than US$2 / day. The survey instrument consisted of a questionnaire and tracking form. Results: 197 of 359 households participated in the survey which encompassed a total of 1023 individuals. Proper housing structure was the most common need (27.7 %) followed by access to transportation (16.1 %) and access to healthcare (15.2 %). Agitated behavior, sad mood, and frequent worries were the most experienced behavioral health concerns with 47.7%, 41.6% and 41.1 % prevalence respectively. Chronic diseases (i.e. high blood pressure, diabetes, asthma) were prevalent in 35 of the households (9.7%). The major disease concern in relation to mosquito borne illness was Dengue (36.0 %). Access to healthcare was an issue in 44 of the 197 households (22.3%) with financial reasons being the most common barrier. Conclusions: Notably, there were no expressed needs for basic necessities such as food, water and medication. This may be due to the help of state programs or a limitation of the survey format. Respondents were most concerned with Dengue but are also at risk for other vector diseases such as Malaria and Chikungunya, highlighting the need to increase awareness and safety measures. Additionally, mental health problems represented a significant burden of disease.
MiR-92a-3p promote s invasion and migration of hepatocellular carcinoma cells by targeting PTEN
Authors: Hu Yilin , Sun Huiling , Lu Qiping , Mei Hongliang , Liu Rong 
Published: May 2021

Abstract
Background

MiR-92a-3p has been reported to play a part in hepatocellular carcinoma (HCC), a leading type of lethal cancer around the world. In this study, we explored the function and mechanism of miR-92a-3p in HCC.
Methods

Firstly, the expression of miR-92a-3p in HCC along with its relationship with PTEN was analyzed through biological information. To investigate the impact of miR-92a-3p on the migration and invasion of HCC cells, we performed scratch wound healing and transwell assays. Next, RT-qPCR, western blot and dual luciferase reporter gene assays were conducted to determine whether PTEN is targeted by miR-92a-3p, which was then verified through rescue assays. Afterwards, in vivo animal experiments were carried out to determine the function of miR-92a-3p in HCC tissues. As an established fact, PETN is an anti-oncogene with frequent mutation inactivation in human cancers. Thus, we used the database to predict the mutation of PETN and its mutation frequency. Finally, CRISPR-cas12a was applied to detect the R130Q mutation on PETN in HCC clinical samples.
Results

This study found that the migration and invasion of HCC could be suppressed by inhibiting miR-92a-3p, which regulates the proliferation, migration and invasion of HCC through the regulation of PETN. The bioinformatics analysis indicated higher mutation frequency of R130Q/G/L* site on the PETN gene, and greater impact of R130Q site mutation on the progression of HCC. CRISPR-cas12a detected 26 cases of R130Q mutations on PTEN in 40 HCC clinical samples
Conclusion

Collectively, this study revealed that miR-92a-3p promoted the invasion and migration of HCC by targeting PTEN, and that the stability of PETN also affected the development of HCC, which may enrich and deepen our knowledge on the progression of HCC.
Characterization and toxicity effect of leachate from municipality landfill
Authors: Sisay Elias Jigar , Sahai Shivraj , Tesfay Teame 
Published: May 2021

Abstract
Leachate from Municipal Solid Waste (MSW) landfill has long known to be an environmental concern worldwide. The composition of landfill leachate may contain metals, ammonia, organics, other toxicants and carcinogens, having major environmental concern, with implications for plant, animal and human health. The pollution of soil, surface and ground water is also some of the major immediate concern related to leachate. This problem is growing at alarming rate in some of the developing countries including Ethiopia, and Adigrat happens to one such fast growing small city Ethiopia. However, in the absence of any significant relevant study for Adigrat City MSW leachate, the present work was undertaken to study the physico-chemical characterization of leachate from the Adigrat MSW leachate and investigate its toxicity effect on pea seed germination (Pisum sativum). The characterization was performed on the leachate from Adigrat MSW landfill. Subsequently, the leachate toxicity assessment on pea seed germination was also carried out. The result shows presence of several unacceptable components in the leachate that in some instance was detected at such levels that may pose environmental risk. It was also found that the low pH may add corrosiveness to any contaminated environmental components. Anions (like Cl−) and heavy metals (like Pb, Zn and Cd) detected in the leachate may also be concern for any possible environmental exposure. Additionally, the pea seed germination experiment suggests existence of such components in the leachate that possibly mask its nutritional property during germination.
Fear of Coronavirus, Stress and Fear of Childbirth in Polish Pregnant Women During SARS-CoV-2 Pandemic
Authors: Dymecka Joanna , Gerymski Rafał , Iszczuk Adrianna , Bidzan Mariola 
Published: May 2021

Abstract
Background: COVID-19 pandemic is the largest pandemic of aggressive coronavirus in the human population in the 21st century. The pandemic may have a negative emotional impact on pregnant women, causing fear and stress. Negative feelings during pregnancy affect the later fear of childbirth. Objective: Out study aimed to determine the relationship between fear of COVID-19, stress and fear of childbirth. We assume that fear of COVID-19 will be a mediator of the relationship between perceived stress and fear of childbirth. Methods: 262 Polish pregnant women participated in this study. Perceived Stress Scale (PSS-10), Fear of COVID-19 Scale (FOC-6), and Labour Anxiety Questionnaire (KLP II) were used in the study. Results: There was a statistically significant, moderate, and positive relationship between perceived stress, fear of COVID-19, and fear of childbirth. Fear of COVID-19 was a statistically significant mediator in the relationship between perceived stress and fear of childbirth Conclusions: The COVID-19 epidemic may have a negative emotional impact on pregnant women, causing fear, stress, and increased fear of childbirth. Childbirth during the COVID-19 pandemic is perceived by women as a threat to their well-being and health. Therefore, it is especially important to support a woman in the perinatal period and to enable her to give birth to a companion.
Giant excitonic upconverted emission of two-dimensional semiconductor in doubly resonant plasmonic nanocavity
Authors: Qi Pengfei , Dai Yuchen , Yang Luo , Tao Guangyi , Zheng Liheng , Zhang Tianhao , Shen Bo , Lin Feng , Fang Zheyu 
Published: May 2021

Abstract
Phonon-assisted upconverted emission lies at the heart of energy harvesting, bioimaging, optical cryptography and optical refrigeration. It has been demonstrated that the emerging two-dimensional (2D) semiconductors can provide a great platform for efficient phonon-assisted upconversion due to the enhanced optical transition strength and phonon-exciton interaction of 2D excitons. However, the research on the further enhancement of excitonic upconverted emission in 2D semiconductors is almost blank. Here we report the enhanced multiphoton upconverted emission of 2D excitons in doubly resonant plasmonic nanocavity. Owing to the enhanced light collection, enhanced excitation rate and quantum efficiency enhancement arising from Purcell effect, the upconverted emission amplification of > 1000 folds and the decrease of 2 ~ 3 orders of magnitude for saturated excitation energy density are achieved. These findings pave the way to the development of excitonic upconversion lasing, nanoscopic thermometry and sensing, and open up the possibility of optical refrigeration in future 2D electronic or excitonic devices.