bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of Inflammation is Disturbed in Acute Ischemic Stroke With Diabetes Mellitus and Rescued By Resolvin D2 Treatment
Authors: Tang Xin , Liu Lan , Miao Zhijuan , Zhang Jiawei , Cai Xiaolong , Zhao Bing-Qiao , Chen Gefei , Schultzberg Marianne , Zhao Yuwu , Wang Xiuzhe 
Published: November 2021

Abstract
Background: Inflammation plays an important role in diabetes mellitus (DM)-related acute ischemic stroke (AIS). The mechanisms of un-resolved inflammation in DM-related AIS are not fully understood. Specialized pro-resolving mediators (SPMs) are key regulators that promote resolution of inflammation. We aimed to examine resolution function in patients with AIS complicated with DM, and explore potential treatment effects of one of the SPMs, resolvin D2 (RvD2) ex vivo and in vivo. Methods: Cultured human macrophages, which were derived from peripheral blood mononuclear cells of AIS and none-AIS patients with or without DM, were stimulated with oxidized-low density lipoprotein (ox-LDL). Levels of SPMs and inflammatory markers were analyzed and RvD2 treatment effects were evaluated in these cells. For experiments in vivo, challenges with high fat diet and low-dose streptozotocin (STZ) were used to induce DM in C57BL/6J mice. AIS model was established by permanent middle cerebral artery occlusion (pMCAO) followed by intra-cerebroventricular injection of RvD2. Results: Compared with macrophages of AIS patients without DM, the ratios of SPMs to leukotriene B4 (LTB4) were decreased in AIS patients with DM, accompanied by reduced expression of SPM synthesis enzyme, 15-lipoxygenase-1. Moreover, the levels of pro-inflammatory pathway markers were increased and the macrophages were skewed to M1 polarization in AIS patients with DM. In mice, treatment with RvD2 ameliorated pMCAO-induced brain injury, neurological dysfunction, and inflammatory response. Furthermore, RvD2 rescued resolution of inflammation by promoting macrophage /microglia polarization to pro-resolving M2 phenotype ex vivo and in vivo. Conclusions: Our data demonstrate resolution of inflammation is impaired by DM in AIS patients, implicating a novel mechanism of un-resolved inflammation in DM-related AIS. Furthermore, RvD2 promotes inflammation resolution in macrophages/microglia and protects DM-related AIS, and may thus serve as a novel therapeutic target.
Induction Cisplatin and Gemcitabine Versus Cisplatin, Fluorouracil, and Docetaxel in Locoregionally Advanced Nasopharyngeal Carcinoma: a Network Meta-analysis
Authors: WU Qiuji , Li Shaojie , Liu Jia , Zhong Yahua 
Published: November 2021

Abstract
Background and purposeCisplatin plus gemcitabine (GP), and cisplatin, fluorouracil plus docetaxel (TPF) has been approved in induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma (LANPC). We compared the clinical outcomes and toxicities of these two regimens by network meta-analysis.Materials and methodsWe systematically searched studies comparing different regimens of IC plus CCRT versus CCRT alone for LANPC. Conventional and Bayesian network meta-analysis were conducted for statistical analysis.ResultsNine eligible studies with a total of 4,977 patients were involved. Compared with CCRT alone, IC+CCRT significantly improved PFS (HR=0.65 [95%CI, 0.54-0.77]) and OS (HR=0.68 [95%CI, 0.54-0.85]) in conventional meta-analysis. In Bayesian network meta-analysis, only TPF and GP improved clinical outcomes significantly. GP showed non-significant trends of superiority over TPF without increasing the incidence of ≥ grade 3 adverse events.Conclusion﻿Induction GP regimen showed non-significant trends of superiority in terms of clinical outcomes compared with TPF regimen in LANPC.
Discontinuing Monoclonal Antibodies Targeting CGRP Pathway After One-Year Treatment: An Observational Longitudinal Cohort Study
Authors: Vernieri Fabrizio , Brunelli Nicoletta , Messina Roberta , Costa Carmelina Maria , Colombo Bruno , Torelli Paola , Quintana Simone , Cevoli Sabina , Favoni Valentina , d'Onofrio Florindo , Egeo Gabriella , Rao Renata , Filippi Massimo , Barbanti Piero , Altamura Claudia 
Published: November 2021

Abstract
Background: The monoclonal antibodies anti-calcitonin gene-related peptide (mAbs anti-CGRP) pathway revolutionized migraine prevention. However, some drug agencies limited the treatment to one year due to their high costs. This study aimed at evaluating the effect of discontinuing mAbs anti-CGRP on monthly migraine days (MMDs) and disability in high-frequency episodic (HFEM) and chronic migraine (CM) patients. Methods: This observational longitudinal cohort study was conducted at 10 Italian headache centres (November 2019-July 2021). Consecutive adult patients followed up for three months (F-UP1-3) after discontinuation of a one-year erenumab/galcanezumab treatment were enrolled. The primary endpoint was the change in F-UP MMDs. Secondary endpoints included variation in pain intensity (Numerical Rating Scale, NRS), monthly painkiller intake (MPI), and HIT-6 scores. We also assessed from F-UP1 to 3 the ≥50% response rates (RR), relapse rate to CM, and recurrence of Medication Overuse (MO).Results: We enrolled 154 patients (72.1% female, 48.2±11.1 years, 107 CM, 47 HFEM); 91 were treated with erenumab, 63 with galcanezumab. From F-UP1 to F-UP3, MMDs, MPI, NRS, and HIT-6 progressively increased but were still lower at F-UP 3 than baseline (Friedman's analysis of rank, p<.001). In the F-UP 1-3 visits, ≥50%RR frequency did not differ significantly between CM and HFEM patients. However, the median reduction in RR at F-UP3 was higher in HFEM (-47.7% [25th, -79.5; 75th ,-17.0]) than in CM patients (-25.5% [25th, -47.1; 75th ,-3.3]; Mann-Whitney U test; p=.032). Of the 84 baseline CM patients who had reverted to EM, 28 (33.3%) relapsed to CM at F-UP1, 35 (41.7)% at F-UP2, 39 (46.4%) at F-UP3. Of the 64 baseline MO patients ceasing MO, 15 (18.3%) relapsed to MO at F-UP1, 26 (31.6%) at F-UP2, and 30 (42.3%, 11 missing data) at F-UP3. Lower MMDs, MPI, NRS, and HIT-6 and higher RR in the last month of therapy characterized patients with 50% RR at F-UP1 and F-UP3 (Mann-Whitney U test; consistently p<.01).Conclusion: Migraine frequency and disability gradually increased after anti-CGRP mAbs interruption. Most patients did not relapse to MO or CM despite the increase in MMDs. Our data suggest to reconsider mAbs anti-CGRP discontinuation.
Analysis of preoperative and postoperative quality of life, sexual function, and sleep in patients with endometriosis: A prospective cohort study
Authors: Halici Belfin Nur Arici , Aktoz Fatih , Kabakci Meric , Kiran Gurkan , Özcan Pinar 
Published: November 2021

Abstract
Purpose
Endometriosis affects the quality of life, sleep, and sexual life of patients due to pain. This study compared the scores of endometriosis patients in these three areas before and after surgery.
Methods
Patients between the ages of 18–60 with a prediagnosis of endometriosis were enrolled. Postoperative histopathological diagnosis of endometriosis was confirmed in all patients. This study included 56 patients who completed pre- and postoperative (three months) evaluation of quality scale questionnaires: a visual analog scale for pelvic pain, the Pittsburgh Sleep Quality Index, Morningness-Eveningness Questionnaire, Endometriosis Health Profile-30 Questionnaire, and Female Sexual Function Index were administered prior to and three months after each patient’s surgery.
Results
Among the 56 female patients included in this study, statistically significant improvement statistically significant improvement was observed in pain scores, quality of life, sexual function, and sleep of all patients regardless of endometriosis stage.
Conclusion
Endometriosis is a disease that progresses, with increasing pain scores; it has negative effects on the quality of life, sexual function, and sleep of patients. Surgical or medical treatment can be performed considering the complaints and fertility status of the patients.
Parameter Identification and The Multi-Switching Sliding Mode Combination Synchronization of Fractional Order Non-Identical Chaotic System Under Stochastic Disturbances
Authors: Pan Weiqiu , Li Tianzeng , Wang Yu 
Published: November 2021

Abstract
This paper deals with the issue of the multi-switching sliding mode combination synchronization (MSSMCS) of fractional order (FO) chaotic systems with different structures and unknown parameters under double stochastic disturbances (SD) utilizing the multi-switching synchronization method. The stochastic disturbances are considered as nonlinear uncertainties and external disturbances. Our theoretical part is divided into two cases, namely, the dimension of the drive-response system are different (or same). Firstly, a FO sliding surface was established in term of fractional calculus. Secondly, depended on the FO Lyapunov stability theory, the adaptive control technology and sliding mode control technique, the multi-switching adaptive controllers (MSAC) and some suitable multi-switching adaptive updating laws (MSAUL) are designed, so that the state variables of the drive systems are synchronized with the different state variables of the response systems. Simultaneously, the unknown parameters are assessed and the upper bound of stochastic disturbances are examined. Selecting the suitable scale matrices, the multi-switching projection synchronization, multi-switching complete synchronization, and multi-switching anti-synchronization will become special cases of MSSMCS. Finally, examples are displayed to certify the usefulness and validity of the demonstrated scheme via MATLAB.
Considering Health Literacy in Cardiovascular Disease Management: A Qualitative Study on Healthcare Professionals’ and Patients' Perspectives
Authors: PERRIN Adèle , Damiolini Eléonore , Schott Anne-Marie , Zermati Jéremy , Bravant Estelle , Delahaye François , Dima Alexandra L. , HAESEBAERT Julie 
Published: November 2021

Abstract
Background: Implementing practices adapted to patient health literacy (HL) is a promising avenue for improving their outcomes in the context of cardiovascular diseases (CVD). The health communication skills of healthcare professionals (HCPs) and the quality of information provided are essential for low-HL patients. We aimed to explore HCPs knowledge about HL, patients and HCPs views on current practices regarding low-HL patients, and facilitators and barriers to adapting communication to patients’ HL level, in order to prepare the implementation of a complex intervention dedicated to improve CVD management for low-HL patients.Methods: We conducted face-to-face semi-structured interviews with HCPs practicing in cardiology units and patients hospitalized for CVD. Study design and analysis were based on the Theory of Planned Behavior for HCPs and the framework of Health Literacy and Health Action for patients. Deductive and inductive thematic analysis were used. Barriers and facilitators were structured into an Ishikawa fishbone diagram and implementation strategies were selected to address resulting themes from the Expert Recommendations for Implementing Change (ERIC).Results: Fifteen patients and 14 HCPs were interviewed. HCPs had partial knowledge of HL dimensions. Perceptions of HCPs and patients were not congruent regarding HCP-patient interactions and information provided by hospital and community HCPs. HCPs perceived they lacked validated tools and skills, and declared they adapted spontaneously their communication when interacting with low-HL patients. Patients expressed unmet needs regarding communication during hospital discharge and at return to home. Conclusion: To implement HL-tailored practices in this setting, our results suggest that several implementation strategies will be valuable at individual (engaging patients and their family), interactional (educating and training of HCPs about HL) and organizational levels (creating a multidisciplinary HCPs interest group dedicated to HL). Trial registration: The study was registered on Clinical Trials: NCT03949309.
A Study of the Plant Folk Nomenclature of the Yi People in Xiaoliangshan, Yunnan Province, China, and the Implications for Protecting Biodiversity
Authors: A·D Yi-Won , Zhang Yu , Ding Xiao-Yong , Guo Chang-An , Wang Yu-Hua 
Published: November 2021

Abstract
BackgroundFolk plant nomenclature is a part of knowledge of indigenous people often used to distinguish plant species. This study aimed to document the folk botanical nomenclature of the Yi people in Xiaoliangshan, north-west Yunnan Province, which has not been systematically investigated to date. The results of this study will assist in conserving biodiversity and the language of the Yi people and will promote the transmission of ethnobotanical knowledge. MethodsAn ethnobotanical survey of plants used by the Yi people in Xiaoliangshan, Yunnan Province, was conducted from September 2019 to August 2021. Semi-structured Interviews and Key Informant Interviews were conducted to collect and document ethnobotanical information, which was then used to analyse the folk botanical nomenclature of the Yi people. In addition, the folk names of plants used by the Xiaoliangshan Yi community were compared with those of the Yi people living in the Daliangshan, where the environment is considerably different.ResultsIn this study, 266 informants were interviewed, and the names of 228 indigenous plants were extracted from 3088 use reports. The nomenclature used by the local Yi people is based on plant characteristics, plant habitat, plant-use, and the local culture. The folk names and the plant species have three types of correspondence. Moreover, some plant names are related to animals or Chinese loanwords. The comparison between the folk botanical names used by the Yi people in Xiaoliangshan and those used by the Yi people in the Daliangshan shows that 55 names are identical and the Yi people in both locations use 41 identical plants.ConclusionsThere are certain similarities and differences between the folk nomenclature of the Yi people in Xiaoliangshan and those in the Daliangshan. The findings are an example of how language evolves when people from the same ethnic group live in different geographical environments for extensive periods. In addition, the numerous Chinese loanwords in the folk botanical names of the Yi people in both locations indicate that a loss of traditional knowledge may be one of the greatest challenges to preserving the cultural heritage of the Yi people and to the conservation of biodiversity.
High-Definition Intravascular Ultrasound Versus Optical Frequency Domain Imaging for the Detection of Calcium Modification and Fracture in Heavily Calcified Coronary Lesion
Authors: Ishida Masaru , Oshikiri Yuya , Kimura Takumi , Sakamoto Ryohei , Shimoda Yudai , Ishikawa Yu , Koeda Yorihiko , Taguchi Yuya , Itoh Tomonori , Morino Yoshihiro 
Published: November 2021

Abstract
Purpose
While optical frequency domain imaging (OFDI) can delineate calcium modification and fracture, the capability of high-definition intravascular ultrasound (HD-IVUS) for detecting these remains unclear. This study evaluated the diagnostic accuracy of HD-IVUS for assessing calcium modification and fracture as compared to OFDI.
Methods
HD-IVUS and OFDI were used during orbital or rotational atherectomy procedures conducted for 21 heavily calcified coronary lesions in 19 patients. With OFDI assessment used as the gold standard, diagnostic accuracies of HD-IVUS for calcium modification and fracture were compared every 1 mm to the matched pre-stenting images (n=1,129). Calcium modification, as assessed by OFDI, was defined as polished and concave-shaped calcium. For HD-IVUS, calcium modification was defined as the presence of reverberation with concave-shaped calcium. In both assessments, the definition of calcium fracture was defined as a slit or complete break in the calcium plate.
Results
Calcified plaque was found in 86.4% of analyzed OFDI images. Calcium modification and fracture were detected in 20.6% and 11.0% of detected calcified plaques. Sensitivity, specificity, positive and negative predictive values of HD-IVUS detection for calcium modification and fracture were 54.4%, 97.8%, 86.7%, 89.1% and 86.0%, 94.5%, 58.2%, 96.8%, respectively. Discordance cases between both assessments demonstrated that heterogeneous calcium visualized by OFDI, separated calcium and guide wire artifact can be misdiagnosed.
Conclusion
Diagnostic accuracies of HD-IVUS for assessing calcium modification and fracture were modest as compared to OFDI. These results suggest that OFDI guidance is more feasible during treatment of heavily calcified coronary lesions versus HD-IVUS guidance.
Determinants of Postnatal Care and Timing of the First Postnatal Care for Newborns in Ethiopia: Further Analysis of 2019 Ethiopian Demographic and Health Survey
Authors: Kebede Sewnet Adem , Weldesenbet Adisu Birhanu , Tusa Biruk Shalmeno 
Published: November 2021

Abstract
Background: Neonatal mortality remain a persisting public health challenge in Ethiopia. Most of the factors that lead to neonatal deaths could be prevented through postnatal check-ups. However, in Ethiopia, coverage of PNC continues to be low. This study aims to assess the determinant factors of PNC visit and the timing of PNC among newborns in Ethiopia.Methods: Using the Ethiopian Mini Demographic and Health Survey (EMDHS) 2019, a total weighted sample of 2,105 women aged 15-49 giving birth in the 2 years preceding the survey was included in the study. Generalized linear mixed model were separately fitted to identify factors associated with any PNC for newborns delivered at home and health facility. Multinomial logistic regression was used to assess timing of PNC with their associated factors.Results: Overall, only 13% (95% CI; 11.2, 14.0) of the newborns received PNC in Ethiopia. Among newborns delivered at home, attending any PNC were determined by region, maternal educational status and birth order. On the other hand, among newborns delivered in a health facility, region, number of ANC visit and religion were determinants of any PNC. Furthermore, attending first PNC within 48 hours after delivery was determined by region and religion. On the other hand, attending first PNC after 48 hours after delivery was determined by region number of ANC visits, maternal educational status and religion. Conclusion: The finding of current study revealed low coverage of PNC among newborns regardless of place of delivery in Ethiopia. The study makes the following recommendation: increase community health literacy on postnatal care, encourage delivery at health facility, link community home birth with PNC. It will be more valuable if there is sharing of experience from regions which have better PNC coverage.
Encoder Hurwitz Integers: The Hurwitz integers that have the ”division with small division” property
Authors: Duram Ramazan , Güzeltepe Murat 
Published: November 2021

Abstract
The residue class set of a Hurwitz integer is constructed by modulo function with primitive Hurwitz integer whose norm is a prime integer, i.e. prime Hurwitz integer. In this study, we consider primitive Hurwitz integer whose norm is both a prime integer and not a prime integer. If the norm of each element of the residue class set of a Hurwitz integer is less than the norm of the primitive Hurwitz integer used to construct the residue class set of the Hurwitz integer, then, the Euclid division algorithm works for this primitive Hurwitz integer. The Euclid division algorithm always works for prime Hurwitz integers. In other words, the prime Hurwitz integers and halves-integer primitive Hurwitz integers have the ”division with small remainder” property. However, this property is ignored in some studies that have a constructed Hurwitz residue class set that lies on primitive Hurwitz integers that their norms are not a prime integer and their components are in integers set. In this study, we solve this problem by defining Hurwitz integers that have the ”division with small remainder” property, namely, encoder Hurwitz integers set. Therefore, we can define appropriate metrics for codes over Lipschitz integers. Especially, Euclidean metric. Also, we investigate the performances of Hurwitz signal constellations (the left residue class set) obtained by modulo function with Hurwitz integers, which have the ”division with small remainder” property, over the additive white Gaussian noise (AWGN) channel by means of the constellation figure of merit (CFM), average energy, and signal-to-noise ratio (SNR).
Patient Perspectives on Key Symptoms and Preferences for Follow-up After Upper Gastro-intestinal Cancer Surgery
Authors: Pucher Phillip H , Coombes Annie , Evans Orla , Taylor Joanna , Moore Jonathan L , White Annabelle , Lagergren Jesper , Baker Cara , Kelly Mark , Gossage James A , Dunn Jason , Zeki Sebastian , Byrne Ben , Andreyev Jervoise , Davies Andrew R 
Published: November 2021

Abstract
Purpose: Long-lasting symptoms and reductions in quality of life are common after oesophago-gastric surgery. Post-operative follow-up has traditionally focussed on tumour recurrence and survival, but there is a growing need to also identify and treat functional sequelae to improve patients’ recovery.Methods: An electronic survey was circulated via a British national charity for patients undergoing oesophago-gastric surgery and their families. Patients were asked about post-operative symptoms they deemed important to their quality of life, as well as satisfaction and preferences for post-operative follow-up. Differences between satisfied and dissatisfied patients with reference to follow-up were assessed.Results: Among 362 respondents with a median follow-up of 58 months since surgery (range 3-412), 36 different symptoms were reported as being important to recovery and quality of life after surgery, with a median 13 symptoms per patient. Most (84%) respondents indicated satisfaction with follow-up. Unsatisfied patients were more likely to have received shorter follow-up than 5 years (27% among unsatisfied patient vs. 60% among satisfied patients, p<0.001) and were less likely to have seen a dietitian as part of routine follow-up (37% vs. 58%, p=0.005).Conclusion: This patient survey highlights preferences regarding follow-up after oesophago-gastrectomy. Longer follow-up and dietician involvement improved patient satisfaction. Patients reported being concerned by a large number of gastrointestinal and non-gastrointestinal symptoms, highlighting the need for multidisciplinary input and a consensus on how to manage the poly-symptomatic patient.