bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions of Unani medicine for maintenance of health with special reference to air quality: an evidence-based review
Authors: Akhlaq Shaheen , Ara Shabnam Anjum , Ahmad Bilal , Fazil Mohammad , Akram Usama , Haque Merajul , Khan Asim Ali 
Published: December 2021

Abstract

Objectives
This article aims to discuss the impact of air quality on human health, measures to achieve the goal of good indoor air quality and proposed benefits of interventions of Unani Medicine with an evidence-based approach.

Content
The significance of air quality on the health of the community cannot be denied. Recent evidences from WHO illustrated data on severe air pollutants and their impacts on human health ranges from minor upper respiratory irritation to chronic respiratory ailments including lung carcinoma and heart disease associated with premature mortality and reduced life expectancy. In Unani Medicine, air has been included in the list of factors, which are six in number and play the central role in prevention of diseases and maintenance of health. Air is considered as the medium of most of the extrinsic factors such as chemical and biological pollutants affecting health and their exposure results in short and long-term health issues. The literature of Unani Medicine proposes many simple and effective measures, which help to improve indoor and outdoor air quality. The goal of outdoor clean air is achieved through implementation of measures to tackle the source of pollution, while indoor clean air is attained through various means e.g., fumigation with herbal drugs. Hence, an extensive literature survey on Unani reserve was conducted to collect information about the concept of air discussed under the heading of six essential factors and its implication in prevention of diseases and maintenance of health. Further, research databases such as Pub Med, Google Scholar, and Science-Direct were broadly searched for evidence on the efficacy of herbals mentioned in Unani literature for the indoor air purification and subsequent air quality improvement.

Summary and outlook
Recent studies showed good air quality leads to decrease in mortality, particularly of respiratory and cardiovascular deaths whereas poor air quality results in a variety of diseases. Unani scholars prescribed several regimens such as Bukhoor (Fumigation), Sa’oot (Nasal instillation) and use of Abeer (Perfumes) and Nadd (Incense) for the improvement of air quality. Likewise various herbal fumigants and sprays containing drugs like mī’a sā’ila (Liquidambar orientalis Mill.), mastagi (Pistacia lentiscus L.), mushk (Moschus moschiferus L.), loban (Styrax benzoides W. G. Craib), ābnoos (Diospyros ebenum J. Koenig ex Retz), zā’fran (Crocus sativus L.) and sirka (vinegar) etc. has been well explained and used exclusively for air purification and improvement of AQI. Therefore, in the present scenario of altered air quality, we forward certain measures described in Unani system of medicine for health promotion and protection. Scientific evidence on several drugs reveal the presence of a number of pharmacologically active substances, which may provide a new approach into the purification of air.
The Priming Effect of a Heavy or Very Heavy Resisted Sled Sprint-Based Conditioning Activity on Subsequent Unresisted Sprint Performance in Team Field Sport Athletes
Authors: Monahan Maria , Egan Brendan 
Published: December 2021

AbstractMonahan, M and Egan, B. The priming effect of a heavy or very heavy resisted sled sprint-based conditioning activity on subsequent unresisted sprint performance in team field sport athletes.J Strength Cond Res37(1): 91–97, 2023—The effect of resisted sled sprinting (RSS) on postactivation performance enhancement (PAPE) was investigated in team field sport athletes (n= 28; m and female, 15 and 13; age, 22.1 ± 2.5 years; height, 1.77 ± 0.11 m; body mass [BM], 75.1 ± 16.4 kg). After a standardized warm-up, unresisted sprint (URS) performance was measured over 10- and 20-m (PRE) followed by a conditioning activity (CA) consisting of 3 × 20 m RSS. Unresisted sprint performance was then measured again at 30 seconds and 4, 8, 12, 16, 20, and 24 minutes after CA. The effect of heavy (H-RSS) or very heavy (VH-RSS) sled loads were compared during 2 separate visits using a randomized crossover design. Heavy-resisted sled sprinting and VH-RSS loads corresponded to a velocity decrement (Vdec) of 17.3 ± 3.6%Vdec(20.0 ± 2.3%BM) and 52.9 ± 3.8%Vdec(64.3 ± 7.0%BM), respectively. Unresisted sprint performance after CA was slower than PRE over 10- and 20-m (bothp< 0.001 for time). The decline in URS performance over 20-m was greater in VH-RSS (time × sled load interaction,p= 0.033). However, after extraction of the fastest sprint times after CA, the fastest sprint time for 10-m improved after H-RSS by 0.026 (0.001, 0.050) seconds (p= 0.040;d= 0.21) but not after VH-RSS (p= 0.054;d= 0.14). The fastest sprint times for 20-m were similar to PRE after H-RSS and VH-RSS. No sex-specific differences were observed. Given the high intersubject variability in the magnitude of improvement, and for the time point at which the fastest sprint occurred, there remains questionable practical value to an RSS-based CA as a means to induce a PAPE for URS performance.
Involvement of Denervated Midbrain-Derived Factors in the Formation of Ectopic Cortico-Mesencephalic Projection after Hemispherectomy
Authors: Chang Leechung , Masada Mayuko , Kojima Masami , Yamamoto Nobuhiko 
Published: December 2021

Neuronal remodeling after brain injury is essential for functional recovery. After unilateral cortical lesion, axons from the intact cortex ectopically project to the denervated midbrain, but the molecular mechanisms remain largely unknown. To address this issue, we examined gene expression profiles in denervated and intact mouse midbrains after hemispherectomy at early developmental stages using mice of either sex, when ectopic contralateral projection occurs robustly. The analysis showed that various axon growth-related genes were upregulated in the denervated midbrain, and most of these genes are reportedly expressed by glial cells. To identify the underlying molecules, the receptors for candidate upregulated molecules were knocked out in layer 5 projection neurons in the intact cortex, using the CRISPR/Cas9-mediated method, and axonal projection from the knocked-out cortical neurons was examined after hemispherectomy. We found that the ectopic projection was significantly reduced when integrin subunit β three or neurotrophic receptor tyrosine kinase 2 (also known as TrkB) was knocked out. Overall, the present study suggests that denervated midbrain-derived glial factors contribute to lesion-induced remodeling of the cortico-mesencephalic projection via these receptors.SIGNIFICANCE STATEMENTAfter brain injury, compensatory neural circuits are established that contribute to functional recovery. However, little is known about the intrinsic mechanism that underlies the injury-induced remodeling. We found that after unilateral cortical ablation expression of axon-growth promoting factors is elevated in the denervated midbrain and is involved in the formation of ectopic axonal projection from the intact cortex. Evidence further demonstrated that these factors are expressed by astrocytes and microglia, which are activated in the denervated midbrain. Thus, our present study provides a new insight into the mechanism of lesion-induced axonal remodeling and further therapeutic strategies after brain injury.
Analysis Of The Punishment Of Penalties By Courts For Wrongful Death During Violation Of Rules Of Road Safety Or Operation Of Transport
Authors: Lutskyi T.M. 
Published: December 2021

The article covers the methodology and results of the analysis of sentencing for violation of traffic safety rules or operation of transport by persons who drive vehicles which caused caused the death of the victim or death (Part 2 and part 3 of Article 286 of the Criminal Code of Ukraine).
The ratio of the type and amount of punishment imposed by courts under this articleі of the Criminal Code of Ukraine on the basis of sentences passed by courts during 2019 is given. The appointment of the courts under the sanction of Part 2 and 3 of Article 286 of the Criminal Code of Ukraine of each of the types of penalty is analyzed. The author outlined the main aspects in the using of these types of punishments by the courts. The article also reveals the characteristics of the application by the courts of the provisions of Articles 69 and 75 of the Criminal Code of Ukraine. Among other things, the author examined the state of application by the courts of additional punishment in the form of deprivation of the right to drive vehicles. According to the results, such an additional punishment in 2019 was applied by courts in less than half of the analyzed sentences.
All court verdicts for 2019, contained in the Unified State Register of court decisions rendered in respect of crimes under Part 2 and Part 3 of Art. 286 of the Criminal Code of Ukraine, which resulted in negligent death of another person.
In addition, the author of the article suggested possible solutions to the problem, which are likely to arise as a result of the mandatory deprivation of the right to drive vehicles. According to the results of the analysis, the author identified the problems that arise when sentencing courts under Part 2 and part 3 of Art. 286 of the Criminal Code of Ukraine and suggested possible ways to solve them. It also covers the expediency of release by a court from serving a sentence of reprimand for negligent death of a person as a result of violation of traffic safety rules and operation of transport, as well as the imposition of a milder punishment than provided by law.
Evolution Of Scientific Approaches To Understanding Local Corporate Lawmaking
Authors: Sulyma A.P. 
Published: December 2021

The article analyzes the origins of the modem understanding of local corporate lawmaking of corporations. The works of both representatives of the Soviet doctrine of the state and law, and the works of modern scholars were analyzed - in particular their views on local lawmaking and local corporate lawmaking of legal entities.
The author expresses an opinion that most modern approaches stem from the doctrine of lawmaking of the Soviet period of science development and do not correspond to the modern development of the legal system (including such a complex area of law as corporate law) and economic relations in Ukraine. The author notes that among the types of local lawmaking, representatives of modern legal theory most often single out lawmaking of non-governmental organization, which dates back to the 70s of the XX century, suggested that they do not take into account the then understanding of the concept of «non-governmental organization».
Concluded that in most works on the theory of law, which distinguish local lawmaking as an independent form, the focus is on lawmaking, which is specifically associated with executive agencies and labor relations.
The author draws the conclusion that local corporate acts appeared in Ukraine and received the first theoretical substantiation by scientists because of the development of market relations and entrepreneurship, as well as the presence of dispositive norms in the laws or lack of regulation of certain relations. These allowed achieving such a settlement by adopting local regulations: the constituent documents (statute and founding agreement) and acts of internal regulation of the legal entity (so-called internal corporate acts).
Possibilities Usage Blockchain Technology For Protect Intellectual Property Rights In Ukraine
Authors: Zinych L.V. 
Published: December 2021

In the article the author explores the prospects of using blockchain technologies to protect intellectual property rights. The purpose of this study is to identify the main advantages of this technology, analysis of foreign legislation and proposals for improving existing legislation. The analysis of activity of operating services on the basis of blockchain technology WIPO Proof, Blinded, Ascribe and practice of their application is carried out.
Promising areas of use of blockchain technology in the field of intellectual property should be: ensuring the automatic storage of data of applications for intellectual property rights; opportunity to confirm intellectual property rights; separations of access rights to the object of intellectual property rights.
Ensuring automatic storage of data of applicants for intellectual property rights. Services based on blockchain technology allow you to securely store user data. The reliability and completeness of the data rests with the user of the services.
Ability to confirm intellectual property rights. Analyzing advantages and disadvantages of blochchain technology, it should be noted that this technology will have a positive result in Ukraine, namely build on the basic technology of blockchain register of intellectual property rights. By analogy with the State Land Cadastral to blockchain technology.
Separation of access right to the object of intellectual property rights. The advantage of this service is the ability to enter into smart contracts, which are confidential because they are stored in encrypted form, reduces time and money. The parties can be sure that the terms of the agreement will be met, and no one will change them.
In conclusion, blockchain technology has significant prospects and provides an opportunity to qualitatively transform the field of intellectual property in the direction of providing reliable evidence of authorship, facilitating content control and user rights management.
The Concept And Legal Nature Of Amendments To The Contract
Authors: Shymanska N.S. 
Published: December 2021

The article examines the concept and legal nature of amendments to the contract. It is established that this legal phenomenon due to the rapid development of market relations is becoming widespread. The meaning of the concept of «change» and its legal nature are analyzed. An exhaustive list of possible options for exercising the right to amend the contract has been made. According to the results of scientific research of different points of view of civilians of different epochs on the concept of «change of contract terms», the own definition of the mentioned concept is formulated and it is proposed to make appropriate changes to the current Civil Code of Ukraine. After all, the perfect legislative regulation of certain relations begins with the consolidation of their definition, in order to have a common understanding of the concept.
In our opinion, the lack of a legislative definition of the term “change of contract terms” is a negative phenomenon, as it leads to unequal understanding of the concept by parties, substitution of concepts, violation of the rights of parties, different case law, which is based on the results of consideration of the category of cases related to amendments to the contract. Therefore, we believe that the CC of Ukraine should be amended by including Article 650 1 «The concept of changing the terms of the contract», by which we mean the process, active behavior of the party (parties), which aims to create new or edit existing terms of the contract to bring it in accordance with certain life circumstances, legal norms, as well as its optimization, the purpose of which is to obtain by the party (parties) a certain positive result of property and / or non-property nature. The implementation of these changes will make it possible to avoid the above-mentioned negative consequences in the future and will ensure the introduction of uniform case law in resolving disputes related to amendments to the contract.
The Influence of Having an Assigned Medicaid Primary Care Physician on Utilization of Otitis Media–related Services
Authors: Berman Stephen , Bondy Jessica , Lezotte Dennis , Stone Barbara , Byrns Patricia J. 
Published: December 2021

Objective.
This study documents the influence of having an assigned Medicaid primary care physician (PCP) on the utilization of otitis media–related services.

Design/Methods.
This is a retrospective study using the 1991 Colorado Medicaid administrative database that followed 28 844 children &lt;13 years who had at least 1 visit for otitis media.

Results.
Children continuously enrolled in Medicaid throughout the entire year were &gt;4 times (odds ratio: 4.2 and 4.89, respectively) as likely to always or sometimes have a PCP compared with children who were discontinuously enrolled. The likelihood of ever using the emergency department for an otitis media–related visit was increased by 26% and 50%, respectively, when a child sometimes or never had a PCP compared with always having a PCP. The likelihood of ever filling an antibiotic for otitis media was reduced by 23% and 34%, respectively, when a child sometimes or never had a PCP compared with always having a PCP. The likelihood of ever having otitis media–related surgery was not affected by PCP status, but young children, 13 to 18 months of age, had higher referral rates when they had an assigned PCP.

Conclusions.
These findings suggest that having an assigned Medicaid PCP influences the utilization patterns of some otitis media–related medical services.
Trends and Variations in Smoking During Pregnancy and Low Birth Weight: Evidence From the Birth Certificate, 1990–2000
Authors: Ventura Stephanie J. , Hamilton Brady E. , Mathews T. J. , Chandra Anjani 
Published: December 2021

Objective. This study compares patterns of tobacco use during pregnancy over time and across population subgroups and examines the impact of maternal smoking on the incidence of low birth weight (LBW). The study also evaluates the use of birth certificates to monitor prenatal smoking.
Methods. The birth certificates of all states (except California) and the District of Columbia for 2000 provided to Centers for Disease Control and Prevention’s National Center for Health Statistics were analyzed. Trends in maternal smoking were examined with data from birth certificates and other relevant sources.
Results. Smoking during pregnancy was reported for 12.2% of women who gave birth in 2000, down 37% from 1989 (19.5%), when this information was first collected on birth certificates. Throughout the 1990s, prenatal smoking rates were highest for older teenagers and women in their early 20s. Among population subgroups, the highest rates were reported for non-Hispanic white women who attended but did not complete high school. The incidence of LBW among singleton infants who were born to smokers was double that for nonsmokers. This relationship was observed in all age groups, for births to Hispanic and non-Hispanic white and black women, and within educational attainment subgroups. Even light smoking (&lt;5 cigarettes daily) was associated with elevated rates of LBW.
Conclusion. Although prenatal smoking may be underreported on the birth certificate, the trends and variations in smoking based on birth certificate data have been confirmed with data from other sources. Birth certificate data can be useful in monitoring prenatal smoking patterns. Changes in the birth certificate questions that are to be implemented beginning in 2003 will help to clarify the levels and changes in smoking behavior during pregnancy so that smoking cessation programs can be more effectively designed to meet the needs of the populations at risk.
Maternal Phenylketonuria: Experiences From the United Kingdom
Authors: Lee Philip J. , Lilburn Maggie , Baudin Jenny 
Published: December 2021

Charles Dent was one of the first physicians to recognize the teratogenic effects of maternal phenylalanine (Phe) on the fetus in 1956. This article describes the clinical experiences of women with phenylketonuria (PKU) within the unit that was established by Dent in the United Kingdom. Between 1977 and 2002, 79 infants were born to women with PKU. Of the 79, 18 (23%) were conceived while the women were on a normal diet with high blood Phe levels. The mean birth weight was 2.89 kg, and head circumference was 32.8 cm. At 1 year, the mean developmental quotient was 105.5 and at 4 years was 82.3. Four of these infants had congenital heart disease (2 of whom died as a result). In the remaining 61 infants, Phe-restricted diet started before conception. None of them had congenital heart disease. The mean birth weight was 3.23 kg, and head circumference was 34.0 cm. At 1 year, mean developmental quotient was 108.0 and at 4 years was 90.9. They continue to be followed up with additional neuropsychometric assessments at 8 and 14 years of age.
This cohort is a proportion of infants who were born to mothers with PKU in the United Kingdom. Between 1978 and 1997, 255 live births were reported. Of these, 56% were conceived on unrestricted diet with subsequently poor outcome. This relatively high rate of conception off PKU diet is likely to reflect the scarcity of medical services for adults with metabolic disorders.
We conclude that many features of the maternal PKU syndrome can be prevented but still occur because of the lack of appropriate resources to care for at-risk women. The precise targets for blood Phe and other nutrients during pregnancy are not entirely clear, neither are the reasons that some offspring are spared the harmful effects of Phe. The impact of the postnatal environment in which these infants find themselves requires additional assessment, too.
The National Survey of Early Childhood Health
Authors: Blumberg Stephen J. , Halfon Neal , Olson Lynn M. 
Published: December 2021

Objectives. The National Survey of Early Childhood Health (NSECH) is a new survey that was designed to provide nationally representative data on the health and development of children and to fill an information gap in the pediatric literature on parents’ views of the delivery of health care to their young children.Design. The selection of topics was guided by previous studies conducted to examine parents’ expectations and needs in child health supervision visits. The NSECH is a random-digit-dial telephone survey of a nationally representative sample of 2068 children aged 4 to 35 months. This sample includes an oversample of black and/or Hispanic children so that results for these minority groups could be estimated with greater precision. The sampling frame for NSECH is from the State and Local Area Integrated Telephone Survey (SLAITS), which is a program of surveys conducted by the National Center for Health Statistics that makes economical use of the large sampling frame of the National Immunization Survey (NIS). SLAITS takes advantage of the NIS screening effort by fielding interviews on other health topics with households screened for the NIS. The respondent was the parent or guardian identified as the person most responsible for the sampled child’s medical care. Spanish-language interviews composed 19% of all completed interviews. The Council of American Survey Research Organizations response rate was 65.6%.Conclusion. The NSECH provides a unique data set that allows a well-rounded picture of the health, health care utilization, health care content, and interpersonal quality of health services received by young children in the United States. It also contains important information about family characteristics, patterns of health-promoting behaviors, and family routines that are associated with promoting the developmental health of young children. NSECH results can also help national policy makers understand the health needs of families with young children and how well the health system is meeting those needs.