bluuebunny/crossref_metadata_2025_split huggingface dataset:
Violência psicológica como mecanismo de censura dos direitos universais das mulheres
Authors: Siqueira Dirceu Pereira , Moraes Carlos Alexandre , Passafaro Valesca Oliveira 
Published: September 2021

É proibida pela Constituição Federal do Brasil de 1988 (CF/88), mencionada no plano nacional, toda e qualquer forma de discriminação contra as mulheres. No seio de seu artigo 3º fica abertamente definido como principal alvo da República gerar sem que se faça qualquer distinção, o bem de todos e de todas, sem preconceito de raça, sexo, cor e idade. No artigo 5º da CF/88 do Brasil, antecipam que homens e mulheres são iguais em seus direitos e obrigações. E ainda, através da revisão dos 20 anos da Declaração e Plataforma de Ação da IV Conferência Mundial Sobre a Mulher, realizada na cidade de Pequim em 1995, os “Estados reunidos” que no mundo todo não existem nenhum lugar que se tenha igualdade de gênero. Com essa constatação no mesmo ano, a adoção da agenda de 2030 para o desenvolvimento sustentável refletiu a cogente necessidade de combater em todo o mundo a desigualdade e discriminação contra todas as mulheres que, em decorrência, se tenha a violência como agente que limita a mulher a ter acesso ao seu desenvolvimento intelectual, profissional, liberdade, autônoma, participação política, educação e saúde. Nesse campo, vale ressaltar que este trabalho teve como objetivo demonstrar que a violência psicológica que estabelece na relação arbitraria de homens com as mulheres perpassa a destruição emocional, Autonomia, autoestima e o pleno desenvolvimento, batendo na esfera da destruição dos Direitos Universais das Mulheres. Isso, através de um sistema conhecido como Patriarcado o qual está enraizado na sociedade contemporânea através de séculos. Este sistema é um contrato ou pacto implícito de homens contra a igualdade de gênero. E que não permite as mulheres o alcance da cidadania e dos seus Direitos arrolados na Constituição Federal do Brasil e nos contratos Internacionais de Proteção à mulher. Este trabalho mostrou que a violência psicológica, ainda pouco comentada apesar da gravidade, é uma das violências primarias nas relações de abuso que em algum momento podem eclodir em morte dessas mulheres. Foi feito uma revisão bibliográfica para verificar as hipóteses aqui levantadas. E os resultados que obtivemos foi de que as relações de poder usam os mesmos mecanismos em que Hanna Harendt menciona em seu livro Da Violência, onde explica que para se manter uma ideologia (política) e submissão dos homens em detrimento de outros homens é necessária a violência, e a violência física será um instrumento usado quando todos os outros meios não forem o bastante. A isso, a violência psicológica a serviço da Estrutura Patriarcal serve como primeira expressão de violência para coibir mulheres para o alcance de sua liberdade, necessitando da violência física quando esta falhar, onde leva a quantidade de mortes de mulheres que vemos na atualidade.
Hyperbaric oxygen treatment for University of Texas grade 3 diabetic foot ulcers: a retrospective cohort study
Authors: Lalieu Rutger C , Mulder Willem , Raap René D Bol , Stolk Saskia , Smit Casper , Dubois Emile FL , van Hulst Rob A 
Published: September 2021

Aim:Hard-to-heal diabetic foot ulcers (DFUs) may increase the risk of amputation. This study reports the positive influence of hyperbaric oxygen therapy (HBOT) on hard-to-heal DFUs involving underlying bone.Method:A single-centre, retrospective cohort study reporting the results of HBOT and wound care on hard-to-heal University of Texas grade 3 DFUs (i.e., involving underlying bone) between 2013 and 2019. Outcome measures were primarily (near-) complete wound healing (i.e., ≥80% ulcer surface area reduction) and amputation rate (minor or major), and secondarily the number of hyperbaric sessions and improvement in quality of life (QoL) and pain score.Results:The study included 206 patients, of whom 74 (36%) achieved complete wound healing, and 75 (36%) near-complete healing. Amputations were performed in 27 patients (13%): 12 (6%) minor and 15 (7%) major. The median number of HBOT sessions was 42. Participants who achieved complete healing received a median of 43 sessions, compared with 10 for those who required major amputation. Patients with at least 30 sessions were less likely to undergo amputation (odds ratio: 0.08; 95% confidence interval (CI): 0.03–0.21). Mean QoL increased by 7.6 points (95%CI: 3.9–11.3; p<0.01) and median pain score fell from 3 to 1 (0–3) (p<0.01).Conclusions:The addition of HBOT to standard wound care may lead to a decreased amputation risk, improved wound healing and increased QoL for people with a University of Texas grade 3 DFU. An adequate number of HBOT sessions is required to achieve optimal clinical results. Objective selection criteria and shared decision-making are suggested to improve dropout rates.
Bioinformatic analysis identifies potential key genes of epilepsy
Authors: Zhu Yike , Huang Dan , Zhao Zhongyan , Lu Chuansen 
Published: September 2021

Background
Epilepsy is one of the most common brain disorders worldwide. It is usually hard to be identified properly, and a third of patients are drug-resistant. Genes related to the progression and prognosis of epilepsy are particularly needed to be identified.

Methods
In our study, we downloaded the Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE143272. Differentially expressed genes (DEGs) with a fold change (FC) >1.2 and a P-value <0.05 were identified by GEO2R and grouped in male, female and overlapping DEGs. Functional enrichment analysis and Protein-Protein Interaction (PPI) network analysis were performed.

Results
In total, 183 DEGs overlapped (77 ups and 106 downs), 302 DEGs (185 ups and 117 downs) in the male dataset, and 750 DEGs (464 ups and 286 downs) in the female dataset were obtained from the GSE143272 dataset. These DEGs were markedly enriched under various Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms. 16 following hub genes were identified based on PPI network analysis: ADCY7, C3AR1, DEGS1, CXCL1 in male-specific DEGs, TOLLIP, ORM1, ELANE, QPCT in female-specific DEGs and FCAR, CD3G, CLEC12A, MOSPD2, CD3D, ALDH3B1, GPR97, PLAUR in overlapping DEGs.

Conclusion
This discovery-driven study may be useful to provide a novel insight into the diagnosis and treatment of epilepsy. However, more experiments are needed in the future to study the functional roles of these genes in epilepsy.
Vegan vs. omnivore diets paradox: A whole-metagenomic approach for defining metabolic networks during the race in ultra-marathoners- a before and after study design
Authors: Devrim-Lanpir Aslı , İlktaç Havvanur Yoldaş , Wirnitzer Katharina , Hill Lee , Rosemann Thomas , Knechtle Beat 
Published: September 2021

BackgroundThe effect of vegan diets on metabolic processes in the body is still controversial in ultra endurance athletes. The study aims to determine gut microbiome adaptation to extreme exercise according to vegan or omnivore diet consumed in ultra-marathoners. We also seek to evaluate long-term vegan diets’ effects on redox homeostasis, and muscle fatigue, and assess energy availability.MethodsSeventy participants will be assigned to the study, including 35 vegan ultra-marathoners and 35 omnivores competing in the Sri-Chinmoy ultra marathon race. Research data will be collected from the participants at four steps (three visits to the research laboratory and the race day) throughout the study. At the first visit (seven days before the race), fecal samples, and anthropometric measurements will be collected. Body composition will be measured using DXA. Participants will be informed about keeping detailed food records and will be asked to record their diet data and activity logs during the entire study period. At second visit, maximum oxygen consumption will be measured on treadmill. On race day, blood samples will be collected immediately before, and 0. min, 2 hours, and 24 hours after the race. Body weight will be measured before and after the race. The blood and fecal samples will be stored at -80 C until analysis. Plasma malondialdehyde, reactive oxygen metabolites, total antioxidant capacity, Heatshockprotein-70, and serum Orosomucoid-1 will be analyzed in blood samples. Fecal samples will be analyzed with shotgun metagenomic analysis and interpreted using bioinformatics pipeline (HumanN2). Statistical tests will be analyzed using SPSS version 23.0 and R Software.DiscussionStudy findings will determine the effects of the vegan diet on sports performance, revealing the multiple interactions between host and gut microbiome at the whole metagenomic level. Additionally, results will show the possible adaptation throughout the race by analyzing blood and fecal samples. Furthermore, by assessing energy availability and determining host-metabolite crosstalk for ultra-endurance athletes, possible nutritional deficiencies can be identified. Thus, advanced nutritional strategies can be developed based on metabolic needs.Trial registrationCurrent controlled trials, ISRCTN registry 69541705. Registered on 8 December 2019.
Noncommunicable diseases risk factors in Bhutan: A secondary analysis of data from Bhutan’s nationwide STEPS survey 2014
Authors: Sithey Gyambo , Wen Li Ming , Dzed Laigden , Li Mu 
Published: September 2021

Background
Bhutan is facing an epidemic of noncommunicable diseases; they are responsible for 53% of all deaths. Four main modifiable risk factors, including tobacco use, harmful use of alcohol, physical inactivity, and unhealthy diet, are the causes of most noncommunicable diseases (NCDs). This study aimed to assess 1) the prevalence of NCDs modifiable risk factors in Bhutan’s adult population and 2) associations between the sociodemographic factors and the NCDs modifiable risk factors with overweight or obesity, hypertension, and diabetes.

Methods
We used the 2014 Bhutan WHO Stepwise Approach to NCD Risk Factor Surveillance (STEPS) Survey dataset in this study. Data were analyzed using multiple logistic regressions, constructed with overweight or obesity, hypertension, and diabetes as outcome variables and modifiable risk factors as independent variables.

Results
The prevalence of tobacco use, harmful use of alcohol, unhealthy diet (low fruits and vegetables intake) and physically inactive was 24.8% (95% CI: 21.5, 28.5), 42.4% (95% CI: 39.4, 45.5), 66.9% (95% CI: 61.5, 71.8), and 6.2% (95% CI: 4.9, 7.8), respectively. The prevalence of overweight or obesity, hypertension and diabetes was 32.9% (95%CI: 30.0, 36.0), 35.7% (95% CI: 32.8, 38.7) and 6.4% (95% CI: 5.1, 7.9), respectively. Multiple logistic regression showed that older age groups were more likely to be overweight or obese, hypertensive, and diabetic. Our analysis also found that tobacco users were less likely to be overweight or obese (aOR 0.71, 95% CI 0.52, 0.96), and to be hypertensive (aOR 0.74, 95% CI 0.56, 0.97); but they were more likely to be diabetic (aOR 1.64, 95% CI 1.05, 2.56). Alcohol users were more likely to be hypertensive aOR 1.41 (95% CI 1.15, 1.74). Furthermore, vigorous physical activity could protect people from being overweight or obese, aOR 0.47 (95% CI 0.31, 0.70), and those consuming more than five serves of fruits and vegetables per day were more likely to be overweight or obese, aOR 1.46 (95% CI 1.17, 1.82).

Conclusion
The prevalence of NCDs modifiable risk factors and overweight or obesity and hypertension was high in Bhutan. We found strong associations between tobacco use and diabetes, alcohol use, hypertension, physically inactive, and overweight or obesity. The results suggest that the government should prioritize NCDs prevention and control programs, focusing on reducing modifiable risk factors. The health sector alone cannot address the NCDs epidemic in Bhutan, and we recommend the whole of government approach to tackle NCDs through the Bhutan Gross National Happiness framework.
Advanced radiotherapy technique in hepatocellular carcinoma with portal vein thrombosis: Feasibility and clinical outcomes
Authors: Khorprasert Chonlakiet , Thonglert Kanokphorn , Alisanant Petch , Amornwichet Napapat 
Published: September 2021

Background
In Thailand, individuals with hepatocellular carcinoma (HCC) who develop portal vein tumor thrombosis (PVTT) have a restricted treatment option because to the extent of the disease, poor underlying liver function, and non-coverage of immuno/targeted therapy. Radiotherapy (RT) plays an increasingly important function in these patients. To investigate the feasibility, efficacy, and adverse event rates, we performed a retrospective analysis of patients with HCC with PVTT who underwent 3-dimensional conformal radiation (3DCRT), intensity-modulated radiation (IMRT), volumetric-modulated radiotherapy (VMAT), and stereotactic body radiotherapy (SBRT) in a single—institution.

Objectives
To examine clinical results in terms of overall survival (OS), local control (LC), response of primary tumor and PVTT, hepatic and gastrointestinal adverse reaction, and prognosis variables for OS and LC.

Materials and methods
Between July 2007 and August 2019, non-metastatic HCC with PVTT patients treated with RT were retrospectively reviewed and evaluated.

Results
The analysis included data from 160 patients. The mean age of the patients was 60.8 years ((95% CI 58.2–62.0). The median diameter of the tumor was 7.7 cm (range: 1–24.5). 85 (54.5%) individuals had PVTT in the main or first branch. At 1.8–10 Gy per fraction, the mean biologically effective dose (BED) as α/β ratio of 10 was 49.6 (95% CI 46.7–52.5) Gy10. The median survival time was 8.3 (95% CI 6.1–10.3) months. Survival rates at one and two years were 39.6% and 17.1%, respectively. Estimated incidence of local failure using competing risk analysis were 24% and 60% at 1 and 2 years, respectively. The overall response rate was 74%, with an 18.5 percent complete response rate. In multivariate analysis, tumor size, overall response, and radiation dose were all significant prognostic variables for OS. Hepatic unfavorable events of grade 3 and 4 were for 14.1% of the total. There was no occurrences of grade 3–4 gastrointestinal toxicity, either acute or late. Additionally, there were no treatment-related mortality.

Conclusions
Advanced RT is regarded as a safe and effective therapeutic option for HCC with PVTT. Overall survival was clearly related to tumor size, radiation dose, and tumor/PVTT response. Individuals with BED 56 Gy10 had significantly better overall survival than patients with BED 56 Gy10. A prospective randomized trial is required to validate these outcomes in order to corroborate these findings.
The NICU flora: An effective technique to sample surfaces
Authors: Sultan Naomi , Shchors Irina , Assous Marc V. , Bar-Meir Maskit 
Published: September 2021

Objective
Environmental surface sampling in healthcare settings is not routinely recommended. There are several methods for environmental surface sampling, however the yield of these methods is not well defined. The aim of the present study is to compare two methods of environmental surface sampling, to characterize the neonatal intensive care unit (NICU) flora, compare it with rates of infection and colonization and correlate it with the workload.

Design and setting
First, the yield of the swab and the gauze-pad methods were compared. Then, longitudinal surveillance of environmental surface sampling was performed over 6 months,once weekly, from pre-specified locations in the NICU. Samples were streaked onto selective media and bacterial colonies were identified using matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF).

Results
The number of colonies isolated using the gauze pad method was significantly higher compared with the swab method. Overall, 87 bacterial species of 30 different bacterial genera were identified on the NICU environmental surfaces. Of these, 18% species were potential pathogens, and the other represent skin and environmental flora. In 20% of clinical cultures and in 60% of colonization cultures, the pathogen was isolated from the infant’s environment as well. The number of bacteria in environmental cultures was negatively correlated with nurse/patient ratio in the day prior to the culture.

Conclusion
The gauze pad method for environmental sampling is robust and readily available. The NICU flora is very diverse and is closely related with the infants’ flora, therefore it may serve as a reservoir for potential pathogens.
The Potential of Bioactive Compound Moringa Leaf to Improve Rabbit Reproductive Performance
Authors: Setiasih Setiasih , Abdurrahman Ahmad Mualif , Soetanto Hendrawan 
Published: September 2021

<p class="awabstrak2">Moringa leaf is a potential animal feed material because it has a complete nutrient content as well as many bioactive compounds. Among its bioactive compounds are phytosterols and isoflavones. This paper aims to describe the importance of moringa leaf as feed supplementation to improve rabbit reproductive performance. The bioactive compounds in moringa leaf have an important role to trigger reproductive hormones.. Phytosterols have a chemical structure similar to that of cholesterol that can be used as precursors of steroid hormones (testosterone, estradiol and progesterone). Isoflavones are one of the flavonoid compounds, also have estrogenic activity and are able to bind with estrogen receptors i.e. ER-α and ER-β. Because of these bioactive compounds, moringa leaves are potential to be utilized as feed supplements as aphrodisiac for bucks, stimulating estrous, and increasing litter size and milk production of does, reduce mortality and increase weaning weight and average daily gain of bunnies.</p>
Beneficial of Bioactive Compound of Rice Bran for Chicken’s Functional Feed
Authors: Hidayat Cecep , Wina Elizabeth , Sopiyana Soni 
Published: September 2021

<p>Rice bran is a feed ingredient as a result of the rice milling process which widely used as an energy source in the feed formulation in the chicken diet. Rice bran contains various nutrients such as oil, protein, carbohydrates (especially starch), beta-glucans, and pectins. Rice bran contains bioactive compounds that have positive effects on the chicken performance and health. Recently, rice bran’s bioactive compounds have been developed as a source of making functional feed. The objective of this study was to review the bioactive compounds in rice bran and their benefits in order to produce chicken’s functional feed. The results of the study showed that rice bran contains oryzanol as an important bioactive compound that has high antioxidant activity. Furthermore, other bioactive compound, lysolecithin, has an ability to reduce cholesterol content in blood, meat and eggs of chicken. Besides, rice bran extract is reported to exert antibacterial activity and has immunomodulator function. It was concluded that the bioactive compounds of rice bran is potential to be used as a substance for making functional feed for chickens.</p>
Processing Technologies of Lignocellulosic Biomass: Potentials and Constraints for Ruminant Feed Production
Authors: Ginting Simon Petrus 
Published: September 2021

<p>Lignocellulosic biomass (LCB) such as crop residues and agro-industrial wastes are renewable resources and available abundantly. It could play central role in sustainable feeding system of ruminant production. These materials are potential source of fiber to support optimum rumen function and energy supply. However, the LCB has important nutritional constraints that limit its utilization as feed for ruminants. This review is intended to discuss nutritional constraints of LCB as ruminant feed and the potentials and challenges of processes in upgrading the nutritional quality of LCB. The main polymer compounds in LCB are cellulose (30 to 60% ), hemicellulose (20 to 40 %) and lignin (15-25%) and its inter linkages make the energy contained in the LCB is less extractable by the ruminant digestive system. Physical, chemical and biological processing technologies have been well known as alternative means to upgrade the nutritive values of LCB. Recently, novel processing technologies of LCB such as ionic liquid, organosolv, sonication, and new screened rot white fungi (<em>Ceriporiopsis subvermispora</em>) and some older technologies using alkaline and acids have been studied and developed particularly for the purpose of biofuel production in the bio refinery industry. Processing technologies have different properties in degrading the lignin, degrading and solubilizing the cellulose and hemicellulose that all relate to the nutritive quality of LCB. Advantages of processed LCB in ruminant animals were indicated by increase in diet digestibility, intake, rumen fermentation and gain. It is concluded that numerous processing technologies are available to upgrade the nutritional quality of LCB, but there are obstacles to use some of these techniques for wide application in ruminant production system.</p>
Lumpy Skin Disease: Ancaman Penyakit Emerging Bagi Kesehatan Ternak Sapi Di Indonesia
Authors: Sendow Indrawati , Assadah Nur Sabiq , Ratnawati Atik , Dharmayanti NLP Indi , Saepulloh Muharam 
Published: September 2021

<p><em>Lumpy skin disease</em> (LSD) menyebabkan kerugian ekonomi bagi peternak sapi, yang disebabkan oleh virus LSD, genus <em>Capripoxvirus</em>, famili <em>Poxviridae</em>. Penyakit ini di karakterisasi dengan adanya nodul pada kulit. Virus ini hanya menginfeksi sapi dan kerbau rawa yang memiliki tingkat mortalitas rendah, namun tingkat morbiditas tinggi. Sedangkan virus ini tidak menginfeksi kambing dan domba. Hingga saat ini, LSD belum pernah dilaporkan di Indonesia, oleh karena itu pengenalan penyakit LSD diperlukan terutama bagi dokter hewan dan paramedis lapangan sehingga infeksi LSD dapat diketahui dan penanganannya dapat dilakukan lebih dini. Tulisan ini akan membahas mengenai penyakit LSD, cara penyebaran penyakit, epidemiologi, diagnosis, faktor risiko serta pengendalian penyakit LSD, sehingga diharapkan masuknya infeksi LSD dapat terdeteksi sedini mungkin dan diantisipasi dengan lebih arif oleh pemangku kebijakan.</p><p> </p>
Optimization of slicing sugar beet for improving the purity of diffusion juice using response surface methodology and genetic algorithm
Authors: Naghipour Zade Maryam , Aghkhani Mohammad Hossein , Rohani Abbas , Behzad Khalil , Kosari-Moghaddam Armaghan 
Published: September 2021

Abstract
The purity is accounted for one of the main characteristics of sugar beet juice in the sugar production process. In this regard, in the paper, the impact of slicing parameters including blade type, slicing angle from 0 to 90°, slicing thickness from 3 to 6 mm, and preheating duration from 3 to 15 min was studied on juice purity using Response Surface Methodology (RSM). The Genetic Algorithm (GA) technique was also employed to find the optimum values of variables to reach the highest juice purity. The results indicated that the quadratic model was the best model to predict juice purity. The Findings presented that as cossette thickness and slicing angle increased, the juice purity was improved. Optimization of the quadratic model by GA showed the best cossette thickness was 6 mm for both blades. The results of optimization indicated that 92.25 and 94.45% juice purities could be obtained from optimum conditions.