bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Disease Activity Influence the Levels of Uric Acid in Psoriatic Arthritis?
Authors: Chu Bruna Burko Rocha , Pereira da Cunha João Pedro Villela Veiga , Marcon João Matheus Tussolini , de Arruda Prado Letícia Eduarda , Rosa Felipe Luis Silva , Leitão Julia Miguel , Thomaz Ana Cláudia , Kowalski Sérgio Cândido , Azevedo Valderílio Feijó 
Published: August 2021

Background:
Hyperuricemia is not only associated with the development of gout but also with renal and vascular dysfunction. The prevalence of this condition has already been studied in psoriasis, but there are a few studies that have been carried out in psoriatic arthritis (PsA). Some studies have shown an association with metabolic syndrome, while others with the extent of cutaneous involvement, but there are no studies that have evaluated the disease activity with compound indexes.

Objective:
The aim of the study was to determine if disease activity, measured by different composite scores, influences the levels of uric acid.

Method:
This was a cross-sectional, observational study, which included 52 PsA patients. Clinical assessments included dactylitis, tender and swollen joint counts, Psoriasis Area and Severity Index, Leeds Enthesis Index, Minimal Disease Activity and Disease Activity for Psoriatic Arthritis. Hyperuricemia was defined as serum uric acid levels ≥ 6mg/dL in females and ≥ 7mg/dL in males.

Results:
Among the 52 included patients, 55.76% were female. The mean age was 54.9 ± 11.6 years. Hyperuricemia occurred in 26.92%. Demographic data, diet, comorbidities and medication were similar between patients with and without hyperuricemia. Patients with hyperuricemia had higher waist circumference (p <0.0046). There was no difference in disease activity between groups, either in the isolated items or in the composite indexes. There was a significant difference in uric acid levels according to the classification of chronic kidney disease by estimated glomerular filtration rate (p=0.0016). Individuals using leflunomide had significantly lower levels of uric acid than those who were not using (p=0.0071).

Conclusion:
This study supports the notion that, in PsA, hyperuricemia is more related to metabolic factors than to disease activity.
Use of magnetic sand to improving writing ability for autistic children in special education laboratories
Authors: Abadi Reza Febri 
Published: August 2021

Abstract: This research is motivated by the availability of an autistic have not been able to write. One of the learning media that is assumed to be able to improve the writing ability of the child is magneticsand. The purpose of this research is to find out the use of magnetic sand to improve writing skills in children with autism. This research was an experiment by using the Single Subject Research (SSR) approach and A – B – A design was as the design of this research. The researcher collected the data by using observation and documentation and the data was analyzed by using in condition and among condition analysis. This research conducted in a month by 4 – 8- 4 (A1 – B – A2) section and by behavior target which made line shapes and vocal letters. The data was obtained on behavior target 1 was 40 % in baseline phase 1 (A1,) 80% in intervention phase, and 71,25 % in the baseline and behavior target 2 was 35 % in baseline phase 1 (A1,), 80 % in intervention phase and 71,25 % in the baseline. Thus, it can be concluded that the use of magnetic sand as a media can improve student’s writing ability.
Pengalaman Orang Tua Anak Berkebutuhan Khusus Mengenai Pembelajaran daring selama Pandemi COVID-19
Authors: Permata Sari Diana , Paska Stephani 
Published: August 2021

Pandemi COVID-19 mempengaruhi berbagai aspek kehidupan manusia. Salah satunya adalah aspek pendidikan. Penelitian kualitatif ini bertujuan untuk menggali perspektif para orang tua terhadap metode pembelajaran daring (dalam jaringan/online) untuk anak berkebutuhan khusus (ABK) selama masa pandemi COVID-19. Pengambilan data dilakukan dengan metode survei pertanyaan terbuka pada google form kemudian dilanjutkan dengan wawancara melalui aplikasi Whatsapp. Responden adalah 43 orang tua dari ABK yang berada Jakarta, Jawa Barat, Jawa Tengah, Yogyakarta serta Jawa Timur. Berdasarkan hasil analisis tematik induktif data ditemukan bahwa orang tua sebagai pendamping anak yang utama selama pembelajaran daring merasa bahwa pembelajaran daring tidak hanya memberikan pengalaman secara negatif bagi mereka namun juga memberikan pengalaman positif bagi para orang tua dan juga anak mereka. Pengalaman positif yang muncul adalah adanya komunikasi dan relasi yang terbangun lebih baik dari sebelumnya antara orang tua dengan guru. Kedua, adanya perkembangan kemampuan anak yang positif selama belajar di rumah seperti kemandirian. Terakhir, orang tua merasa kemampuan penguasaan materi maupun teknologi bertambah dengan adanya sistem pembelajaran daring. Sedangkan tema terkait pegnalaman negatif dari pembelajaran secara daring adalah adanya kebutuhan khusus tertentu yang mengalami kesulitan dengan penggunaan media daring untuk pembelajaran. Lalu, kendala kuota serta keterbatasan perangkat elektronik yang digunakan merupakan pengalaman negatif yang banyak ditemui oleh para guru serta orang tua. Beberapa orang tua menyimpulkan jika pembelajaran daring tidak cocok untuk disabilitas tertentu.
A Patient Decision Aid for Anticoagulation Therapy in Patients With Nonvalvular Atrial Fibrillation: Development and Pilot Study
Authors: de Castro Kim Paul , Chiu Harold Henrison , De Leon-Yao Ronna Cheska , Almelor-Sembrana Lorraine , Dans Antonio Miguel 
Published: August 2021

Background
Atrial fibrillation (AF) is one of the most common predisposing factors for ischemic stroke worldwide. Because of this, patients with AF are prescribed anticoagulant medications to decrease the risk. The availability of different options for oral anticoagulation makes it difficult for some patients to decide a preferred choice of medication. Clinical guidelines often recommend enhancing the decision-making process of patients by increasing their involvement in health decisions. In particular, the use of patient decision aids (PDAs) in patients with AF was associated with increased knowledge and increased likelihood of making a choice. However, the majority of available PDAs is from Western countries.

Objective
We aimed to develop and pilot test a PDA to help patients with nonvalvular AF choose an oral anticoagulant for stroke prevention in the local setting. Outcomes were (1) reduction in patient decisional conflict, (2) improvement in patient knowledge, and (3) patient and physician acceptability.

Methods
We followed the International Patient Decision Aid Standards (IPDAS) to develop a mobile app–based PDA for anticoagulation therapy in patients with nonvalvular AF. Focus group discussions identified decisional needs, which were subsequently incorporated into the PDA to compare choices for anticoagulation. Based on recommendations, the prototype PDA was rendered by at least 30 patients and 30 physicians. Decisional conflict and patient knowledge were tested before and after the PDA was implemented. Patient acceptability and physician acceptability were measured after each encounter.

Results
Anticoagulant options were compared by the PDA using three factors that were identified (impact on stroke and bleeding risk, and price). The comparisons were presented as tables and graphs. The prototype PDA was rendered by 30 doctors and 37 patients for pilot testing. The mean duration of the encounters was 15 minutes. The decisional conflict score reduced by 35 points (100-point scale; P<.001). The AF knowledge score improved from 10 to 15 (P<.001). The PDA was acceptable for both patients and doctors.

Conclusions
Our study showed that an app-based PDA for anticoagulation therapy in patients with nonvalvular AF (1) reduced patient decisional conflict, (2) improved patient knowledge, and (3) was acceptable to patients and physicians. A PDA is potentially acceptable and useful in our setting. A randomized controlled trial is warranted to test its effectiveness compared to usual care. PDAs for other conditions should also be developed.
Areas of Interest and Attitudes Toward Antiobesity Drugs: Thematic and Quantitative Analysis Using Twitter
Authors: Alvarez-Mon Miguel Angel , Llavero-Valero Maria , Asunsolo del Barco Angel , Zaragozá Cristina , Ortega Miguel A , Lahera Guillermo , Quintero Javier , Alvarez-Mon Melchor 
Published: August 2021

Background
Antiobesity drugs are prescribed for the treatment of obesity in conjunction with healthy eating, physical activity, and behavior modification. However, poor adherence rates have been reported. Attitudes or beliefs toward medications are important to ascertain because they may be associated with patient behavior. The analysis of tweets has become a tool for health research.

Objective
The aim of this study is to investigate the content and key metrics of tweets referring to antiobesity drugs.

Methods
In this observational quantitative and qualitative study, we focused on tweets containing hashtags related to antiobesity drugs between September 20, 2019, and October 31, 2019. Tweets were first classified according to whether they described medical issues or not. Tweets with medical content were classified according to the topic they referred to: side effects, efficacy, or adherence. We additionally rated it as positive or negative. Furthermore, we classified any links included within a tweet as either scientific or nonscientific. Finally, the number of retweets generated as well as the dissemination and sentiment score obtained by the antiobesity drugs analyzed were also measured.

Results
We analyzed a total of 2045 tweets, 945 of which were excluded according to the criteria of the study. Finally, 320 out of the 1,100 remaining tweets were also excluded because their content, although related to drugs for obesity treatment, did not address the efficacy, side effects, or adherence to medication. Liraglutide and semaglutide accumulated the majority of tweets (682/780, 87.4%). Notably, the content that generated the highest frequency of tweets was related to treatment efficacy, with liraglutide-, semaglutide-, and lorcaserin-related tweets accumulating the highest proportion of positive consideration. We found the highest percentages of tweets with scientific links in those posts related to liraglutide and semaglutide. Semaglutide-related tweets obtained the highest probability of likes and were the most disseminated within the Twitter community.

Conclusions
This analysis of posted tweets related to antiobesity drugs shows that the interest, beliefs, and experiences regarding these pharmacological treatments are heterogeneous. The efficacy of the treatment accounts for the majority of interest among Twitter users.
Self-directed Technology-Based Therapeutic Methods for Adult Patients Receiving Mental Health Services: Systematic Review
Authors: Saad Anthony , Bruno Deanna , Camara Bettina , D’Agostino Josephine , Bolea-Alamanac Blanca 
Published: August 2021

Background
Technological interventions used to treat illnesses and promote health are grouped under the umbrella term of digital therapeutics. The use of digital therapeutics is becoming increasingly common in mental health. Although many technologies are currently being implemented, research supporting their usability, efficacy, and risk requires further examination, especially for those interventions that can be used without support.

Objective
This review aims to identify the evidence-based, self-directed, technology-based methods of care that can be used in adult patients after they are discharged from mental health services. The interventions reviewed are automated with no human input required (either at the patient’s or at the technology’s end), so the patients can implement them without any support.

Methods
A systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and PROSPERO (International Prospective Register of Systematic Reviews) guidelines in 3 databases: PubMed, Web of Science, and OVID. The inclusion criteria were self-directed, automated, and technology-based interventions related to mental health, primarily for adults, having a solid evaluation process. The interventions had to be self-directed, in that the participants could use the technology without any external guidance.

Results
We identified 36 papers that met the inclusion criteria: 26 randomized controlled trials, 9 nonrandomized controlled trial quantitative studies, and 1 qualitative study. The technologies used included websites, automated text messaging, phone apps, videos, computer software, and integrated voice response. There were 22 studies focused on internet-based cognitive behavioral therapies as a therapeutic paradigm compared with the waitlist, web-based human-delivered therapy, and other interventions. Among these studies, 14 used paradigms other than the internet-based cognitive behavioral therapy. Of the 8 studies comparing guided and unguided digital care, 3 showed no differences, 3 favored guided interventions, and 2 favored unguided interventions. The research also showed that dropout rates were as high as 80%, citing potential problems with the acceptability of the suggested technologies.

Conclusions
There is limited research on the efficacy and suitability of self-directed technology-based care options for mental health. Digital technologies have the potential to bridge the gap between ambulatory care and independent living. However, these interventions may need to be developed collaboratively with the users to encourage their acceptability and to avoid high dropout rates.
Peningkatan kualitas pembelajaran melalui lesson study learning community pada materi “waktu 24 jam” di Sekolah Dasar
Authors: Wahyuni Sri , Eko Susetyarini Roro , Prihanta Wahyu , Yuliana Firdiani 
Published: August 2021

The main task of the teacher in the learning process is to lead participants to achieve their learning goals. Thus, teachers are required to always improve the quality of their learning, one of which is through the Lesson Study Learning Community (LS-LC). The purpose of this research is to describe the implementation of the Lesson Study Learning Community in SD (Sekolah Dasar-Primary School) Junrejo I, in “the 24-hour clock” material. This qualitative research employed a single case study and explained it naturally. The respondents were one teacher and 28-second graders. There were three stages in the implementation of lesson study, namely: plan, do and see. The data collection technique were using documentation and unstructured interview. The data were analyzed in a quantitative and qualitative description. The findings in the planned activity were the collaboration of teachers and lecturers in innovating and creating chapter and lesson design of “the 24-hour clock” material, considering the characteristic of students. In the open class (do the activity), the students were conducting discussions and observations. During learning, the students were comparing digital and non-digital clocks while lecturers and teachers were observing the learning process. In the seen activity, the observation result from teachers and lecturers were revealed. The implementation of Lesson Study Learning Community in grade II SD Junrejo I, on the material "24 hour time" had been going well. But the results shown that students were able to understand the material as much as 60%, students were able to collaborate in groups 45%, student’s expression was happy, excited, motivating, and cheerful, as much as 90%. It needs replanning with changes in seating arrangements, group arrangements, and group members
A theoretical analysis of longitudinal temporomandibular joint compressive stresses and mandibular growth
Authors: Desai Riddhi J. , Iwasaki Laura R. , Kim Sohyon M. , Liu Hongzeng , Liu Ying , Nickel Jeffrey C. 
Published: August 2021

ABSTRACT

Objectives
To determine if temporomandibular joint (TMJ) compressive stresses during incisor biting (1) differed between growing children over time, and (2) were correlated with Frankfort Horizontal-mandibular plane angle (FHMPA, °) and ramus length (Condylion-Gonion (Co-Go), mm).

Materials and Methods
Three-dimensional anatomical geometries, FHMPA and Co-Go, were measured longitudinally from lateral and posteroanterior cephalographs1 of children aged 6 (T1), 12 (T2), and 18 (T3) years. Geometries were used in numerical models to estimate subject-specific TMJ eminence shape and forces for incisor bite-forces of 3, 5, and 8 Newtons at T1, T2, and T3, respectively. TMJ compressive stresses were estimated via two steps: First, TMJ force divided by age-dependent mandibular condylar dimensions, and second, modified by loading surfaces' congruency. Analysis of variance and Tukey honest significant difference post-hoc tests, plus repeated measures and mixed effects model analyses were used to evaluate differences in variables between facial groups. Regression analyses tested for correlation between age-dependent compressive stresses, FHMPA, and Co-Go.

Results
Sixty-five of 842 potential subjects had T1-T3 cephalographs and were grouped by FHMPA at T3. Dolichofacial (FHMPA ≥ 27°, n = 36) compared to meso-brachyfacial (FHMPA&lt; 27°, n = 29) subjects had significantly larger FHMPA at T1-T3, shorter Co-Go at T2 and T3 (all P &lt; .01), and larger increases in TMJ compressive stresses with age (P &lt; .0001). Higher compressive stresses were correlated with larger FHMPA (all R2 ≥ 0.41) and shorter Co-Go (all R2 ≥ 0.49).

Conclusions
Estimated TMJ compressive stress increases from ages 6 to 18 years were significantly larger in dolichofacial compared to meso-brachyfacial subjects and correlated to FHMPA and Co-Go.
Incisor position and alveolar bone thickness:
Authors: Andrews Will A. , Abdulrazzaq Wakas S. , Hunt Jeffrey E. , Mendes Lucas M. , Hallman Linda A. 
Published: August 2021

ABSTRACT

Objectives
To evaluate incisor position and its relationship to alveolar bone in untreated optimal occlusions and in untreated Class II malocclusions.

Materials and Methods
Fifty-seven lateral cephalograms of individuals with naturally occurring optimal occlusions (mean age = 23 years) were used to assess positions of central incisors and their relationships to alveolar bone. Data were compared to a sample of 57 individuals with untreated Class II malocclusions with concurrent anterior-posterior (AP) skeletal discrepancies (mean age = 16.9 years).

Results
Significant intergroup differences were found for AP jaw relationship, maxillary alveolar bone thickness, mandibular incisor inclination, maxillary incisor root distance to labial surface of alveolar bone, and mandibular incisor root apex distance to labial surface of alveolar bone. Small differences between females and males existed for several variables. In both samples, maxillary incisor roots were located closer to the labial surface of alveolar process than to the palatal surface by roughly a 2:1 ratio. Mandibular incisor root apices were generally equidistant from the labial and lingual surfaces of the alveolus in the optimal sample but closer to the lingual surface in the Class II sample.

Conclusions
Maxillary incisors tend to occupy the anterior one-third of the alveolus in untreated individuals, regardless of AP interarch dental relationships or AP jaw relationships. Mandibular incisor root apices tend to be centered within the alveolus in untreated optimal occlusions but are more positively inclined, and their root apices are more posterior in untreated Class II malocclusions.
THERMAL METHODS OF INCREASING CRUDE-OIL YIELD OF THE MYOCENE FIELDS OF OLD-GROZNYY AND MALGOBEK – VOZNESENSKY DEPOSITS
Authors: Исламов Д.А. 
Published: August 2021

Рассмотрены способы увеличения нефтеотдачи пластов для миоценовых залежей месторождений Чеченской Республики и Ингушетии с применением различных теплоносителей: паротепловое воздействие на Старогрозненском и Малгобек – Вознесенском месторождении, влажное внутрипластовое горение на Малгобек – Вознесенском месторождении. Выполнен анализ результатов проведенных работ и дана оценка возможных применений в других районах со сходными горно-геологическими условиями.
Some methods of increasing crude-oil yield of the myocene fields of the Chechen republic and Ingushetia oilfield with the application of different heat-transfer agents are examined: steam-heat action on the the oldGroznyy and Malgobek – Voznesensky oilfield, moist intra-stratified combustion on Malgobek – Voznesensky oilfield. The analysis of the carried out works results. The analysis of the results of the carried out works is executed is executed and estimation of possible applications in other regions with the similar mining geological conditions is given.
DYNAMICS OF GROUNDWATER BASIN FUNCTIONING – A POSSIBLE MANIFESTATION OF THE CATASTROPHIC FLOODS
Authors: Конешов В.Н. , Трифонова Т.А. , Трифонов Д.В. , Аракелян С.М. 
Published: August 2021

Обсуждается возможное влияние тектонических напряжений на возникновение катастрофических наводнений посредством механизма модификации 3D-сетей скальных формаций и транзита подземных вод в этой естественной транспортной системы в условиях функционирования водосборного бассейна реки. Считается, что несколько наводнений (не паводков) имевших место в 2013-2014 годы, вероятно, могли быть связаны с соответствующими сейсмическими процессами в земной коре. В практическом аспекте предлагаемая гипотеза может оказаться полезной при предварительном определении потенциально опасных районов, где могут происходить катастрофические события, связанные с водой, принимая во внимание влияния состояния подземной гидросферы и тектонической структуры реологического участка земных недр на конкретных территориях.
Possible influence of tectonic stresses on the occurrence of catastrophic floods by the mechanism of modification of the 3D-cracknet of the rock formations and the transit of the groundwater in this natural transport system in the conditions of functioning of the river catchment basin is discussed. Several floods (not freshets) took place in 2013-2014, which probably could be associated with corresponding seismic processes in the earth’s crust, are considered. In the practical aspect proposed hypothesis can be useful during the preliminary definition of potentially dangerous areas for catastrophic water events taking into account the interference of the state of the underground hydrosphere and the tectonic structure of the rheological section of bowels of the earth on the concrete territories.
PROBABILISTIC MODELSOF SEISMIC EFFECTS PREDICTION FOR SEISMIC HAZARD IN ENGINEERING PURPOSESFORECASTING
Authors: Чернов Ю.К. , Чернов А.Ю. 
Published: August 2021

Предложены вероятностные модели пиковых ускорений, спектров и других параметров сильных движений, основанные на статистическом анализе большого объема данных по инструментальной регистрации землетрясений. Модели позволяют повысить точность и надежность прогнозных оценок на региональном и локальном уровне за счет более полного учета особенностей потенциально опасных очагов землетрясений и свойств окружающей геологической среды, включая местные грунтовые условия.
Probability models of peak acceleration, spectra and other strong motion parameters based on statistical analysis of large amounts of data on the instrumental registration is proposed. Models can increase the accuracy and reliability of projections at the regional and local level, through better integration of potentially hazardous characteristics of earthquakes and geological environment properties, including local ground conditions.