bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient and public involvement in stroke research: a scoping review protocol
Authors: Hall Patricia , Kroll Thilo , Hickey Julianne , Stokes Diarmuid , Lennon Olive 
Published: November 2021

Background: Growing consensus supports public and patient involvement (PPI) in research as the lived experience of patients, family carers and users of health and social care services bring unique insights to healthcare research. The impact and burden of stroke present ongoing challenges for those living with its consequences and could potentially limit PPI activity. This review aims to explore PPI in published stroke research to identify and describe the extent, nature and design of PPI activities, the type/s of studies involved and the profile of PPI participants engaged in stroke research. Methods: This systematic scoping review, guided by the Arksey & O’Malley five step framework, will be reported according to the PRISMA-ScR reporting guidelines. PPI is embedded at each stage of this proposed scoping review from conceptualisation, participation, contribution and collaboration. The Population, Concept, Context (PCC) structure defines the research question which asks - How is PPI in stroke research currently being conducted and how do the study authors report their PPI activities and its impact? A comprehensive range of electronic databases including PubMed, CINAHL, EMBASE, PsychINFO and the Cochrane Database of Systematic Reviews will generate a broad range of studies. Grey literature (e.g. OpenGrey, Leanus) and internationally recognised stroke organisation websites will be searched for additional research reports. Data extraction will adhere to the Joanna Briggs Institute guidelines, with results collated and mapped to the research cycle stage/s. Conclusions: The outlined scoping review protocol will comprehensively identify and map the existing scientific literature that reports PPI in stroke research. Findings will be presented in relation to PPI conceptualisation, participant profiles and activities in stroke research, volume, type and range of approaches. Knowledge gaps and future priorities for PPI in stroke research will be identified.
Variation in Formula Supplementation of Breastfed Newborn Infants in New York Hospitals
Authors: Nguyen Trang , Dennison Barbara A. , Fan Wei , Xu Changning , Birkhead Guthrie S. 
Published: November 2021

OBJECTIVES
We examined the variation between 126 New York hospitals in formula supplementation among breastfed infants after adjusting for socioeconomic, maternal, and infant factors and stratifying by level of perinatal care.

METHODS
We used 2014 birth certificate data for 160 911 breastfed infants to calculate hospital-specific formula supplementation percentages by using multivariable hierarchical logistic regression models.

RESULTS
Formula supplementation percentages varied widely among hospitals, from 2.3% to 98.3%, and was lower among level 1 hospitals (18.2%) than higher-level hospitals (50.6%–57.0%). Significant disparities in supplementation were noted for race and ethnicity (adjusted odds ratios [aORs] were 1.54–2.05 for African Americans, 1.85–2.74 for Asian Americans, and 1.25–2.16 for Hispanics, compared with whites), maternal education (aORs were 2.01–2.95 for ≤12th grade, 1.74–1.85 for high school or general education development, and 1.18–1.28 for some college or a college degree, compared with a Master’s degree), and insurance coverage (aOR was 1.27–1.60 for Medicaid insurance versus other). Formula supplementation was higher among mothers who smoked, had a cesarean delivery, or diabetes. At all 4 levels of perinatal care, there were exemplar hospitals that met the HealthyPeople 2020 supplementation goal of ≤14.2%. After adjusting for individual risk factors, the hospital-specific, risk-adjusted supplemental formula percentages still revealed a wide variation.

CONCLUSIONS
A better understanding of the exemplar hospitals could inform future efforts to improve maternity care practices and breastfeeding support to reduce unnecessary formula supplementation, reduce disparities, increase exclusive breastfeeding and breastfeeding duration, and improve maternal and child health outcomes.
Weapon Carrying Among Victims of Bullying
Authors: Pham Tammy B. , Schapiro Lana E. , John Majnu , Adesman Andrew 
Published: November 2021

OBJECTIVES
To examine, in a large, nationally representative sample of high school students, the association between bullying victimization and carrying weapons to school and to determine to what extent past experience of 1, 2, or 3 additional indicators of peer aggression increases the likelihood of weapon carrying by victims of bullying (VoBs).

METHODS
National data from the 2015 Youth Risk Behavior Survey were analyzed for grades 9 to 12 (N = 15624). VoB groups were determined by self-report of being bullied at school and additional adverse experiences: fighting at school, being threatened or injured at school, and skipping school out of fear for one’s safety. Weapon carrying was measured by a dichotomized (ie, ≥ 1 vs 0) report of carrying a gun, knife, or club on school property. VoB groups were compared with nonvictims with respect to weapon carrying by logistic regression adjusting for sex, grade, and race/ethnicity.

RESULTS
When surveyed, 20.2% of students reported being a VoB in the past year, and 4.1% reported carrying a weapon to school in the past month. VoBs experiencing 1, 2, or 3 additional risk factors were successively more likely to carry weapons to school. The subset of VoBs who experienced all 3 additional adverse experiences were more likely to carry weapons to school compared with nonvictims (46.4% vs 2.5%, P &lt; .001).

CONCLUSIONS
Pediatricians should recognize that VoBs, especially those who have experienced 1 or more indicators of peer aggression in conjunction, are at substantially increased risk of weapon carrying.
Income, ethnic diversity and family life in East London during the first wave of the pandemic: An assets approach
Authors: Cameron Claire , O'Brien Margaret , Whitaker Lydia , Hollingworth Katie , Hauari Hanan 
Published: November 2021

Objective: This paper reports first results from a survey of 992 parents and parents to be living in an ethnically diverse and socio-economically unequal borough of East London during the coronavirus pandemic that reduced mobility, closed services and threatened public health.
Background: Little is known about the place based impacts of the pandemic on families with young children. We describe the living circumstances of families with children under five or expecting a baby living in Tower Hamlets during the Coronavirus pandemic in 2020, and then examine the relative importance of household characteristics such as ethnicity and household income for adverse impacts on survey respondents, as seen in mental health outcomes.
Method: a community survey sample recruited with support from the local council comprised 75% mothers/pregnant women, 25% fathers/partners of pregnant women. Reflecting the borough population, 35 percent were White British or Irish and 36 percent were Bangladeshi, and the remainder were from a wide range of ethnic backgrounds. Adopting an assets based approach, we describe material, familial and community assets using three household income bands and seven ethnic groups. We then use regressions to identify which assets were most important in mitigating adversity.
Results: We find that material assets (income, employment, food insecurity, housing quality) were often insecure and in decline but familial assets (home caring practices, couple relationships) were largely sustained. Community assets (informal support, service provision) were less available or means of access had changed. Our analyses find that while descriptively ethnicity structured adverse impacts of the pandemic related changes to family life, income and couple relationships were the most important assets for mitigating adversity as seen in mental health status.
Conclusion: Supporting family assets will require close attention to generating local and decent work as well as enhancing access to community assets.
Peningkatan Kemampuan Anak Mendeteksi Makanan Sehat Melalui Pesan Bergambar dalam Kemasan Makanan
Authors: Marlinae Lenie , Husaini Husaini , Kania Nia , Nurhikmah Nurhikmah , Khairiyati Laily , Jinan Raudatul 
Published: November 2021

Upaya perbaikan gizi untuk mengembangkan bakat yang berkualitas pada dasarnya harus dimulai sedini mungkin, salah satunya pada anak usia sekolah. Siswa sekolah dasar merupakan sasaran strategis untuk meningkatkan gizi lokal. Makanan kaya nutrisi dapat diperoleh dari makanan dan snack. Apabila membeli makanan yang sudah sesuai dengan syarat kesehatan, maka rutinitas makan di sekolah bisa sangat bermanfaat dan bisa melengkapi atau melengkapi kebutuhan nutrisi anak. Edukasi kemasan makanan, termasuk pesan visual, perlu dapat membentuk sikap yang benar agar anak memilih serta makan jajanan yang aman dan sehat. Metodologi yang digunakan meliputi fase pengenalan ABG (advokasi, pengembangan masyarakat, dan gerakan masyarakat), penelitian lapangan, dan evaluasi menggunakan metodologi pre-test dan post-test. Menurut hasil pre-test, 26 orang (86,7%) menilai pemahamannya positif, dan setelah diberikan pelatihan dan materi, 30 orang (100%) positif menurut hasil post-test. Tingkat pengetahuan. Oleh karena itu, pemahaman masyarakat tentang penggunaan masker bersih dan sehat semakin hari semakin meningkat. Pengetahuan tingkat lanjut sangat membantu dalam mencegah anak dari makan makanan yang tidak sehat. Kata kunci: deteksi makanan, gizi anak, makanan sehat
Pemanfaatan Lahan Gambut Di Kawasan Transmigran Desa Sidomulyo Kecamatan Wanaraya Kabupaten Barito Kuala
Authors: Putro Herry Porda Nugroho , Syarifuddin Syarifuddin , Arisanty Deasy , Arifin Anis Mohamad Zaenal 
Published: November 2021

This study aimed to obtain data on the use and utilization of peatlands that the government has provided to meet their daily needs. Peatlands, which are very difficult to manage, challenge transmigrant communities to turn them into productive land. The method used was qualitative with a descriptive approach to reveal the facts in the field. Data collection used interviews, document studies, and direct observation of the field. Based on the data, it is known that the transmigrant community used peatland for mixed gardens, with 1010 plots of land used for seasonal crops (vegetables, oranges and rice) and perennials (rubber, oil palm and coconut), 480 plots of land were for settlements, and as many as 32 plots of land were used for mosques, cemeteries and schools. This data was obtained from the National Land Agency (BPN) Kab. Barito Kuala, interviews, and direct observations with the people who cultivate the land. The results obtained explain that the use of peatlands by transmigrants was certainly an illustration that peatlands could still be used as productive and comfortable land to be used as settlements/residences and for community livelihoods. With proper management, the use of peatland would provide great benefits, not only for the present but also for the future.Keywords: Peatlands; Transmigran Community; Utilization Penelitian ini bertujuan memperoleh data mengenai penggunaan dan pemanfaatkan lahan gambut yang telah diberikan oleh pemerintah guna memenuhi kebutuhan hidupnya. Lahan gambut yang notabennya sangat sulit dikelola menjadi tantangan bagi masyarakat transmigran untuk menjadikannya lahan produktif. Metode yang digunakan adalah kualitatif dengan pendekatan deskriptif untuk mengungkap fakta yang terdapat di lapangan. Pengumpulan data menggunakan teknik wawancara, studi dokumen, dan observasi langsung ke lapangan. Berdasarkan data yang diperoleh diketahui bahwa masyarakat transmigran menggunakan lahan bergambut untuk kebun campuran yaitu sebanyak 1010 bidang tanah digunakan untuk tanaman musiman (sayuran, jeruk dan padi) dan tanaman keras (karet, sawit dan kelapa), 480 bidang tanah untuk permukiman, dan sebanyak 32 bidang tanah yang digunakan untuk masjid/langgar, kuburan, dan sekolah. Data ini diperoleh dari Badan Pertanahan Nasional (BPN) Kabupaten Barito Kuala, wawancara, dan observasi langsung dengan masyarakat yang mengolahan lahan tersebut. Hasil yang diperoleh menerangkan bahwa penggunaan lahan bergambut oleh masyarakat transmigran tentu menjadi gambaran bahwa lahan gambut masih bisa dijadikan lahan yang produktif dan nyaman untuk dijadikan permukiman/tempat tinggal serta untuk penghidupan masyarakat. Dengan pengolahan yang tepat, pemanfaatan lahan bergambut dapat bermanfaat dengan baik secara berkelanjutan.Kata Kunci: Lahan Gambut; Masyarakat Transmigran; Pemanfaatan
PENGARUH RELIGIUSITAS TERHADAP KESEJAHTERAAN SUBJEKTIF PADA KELUARGA IBU BEKERJA INFORMAL SELAMA PANDEMI COVID-19
Authors: Rizkillah Risda , Anjar Wati Restu 
Published: November 2021

Pandemi Covid-19 memberikan dampak pada kesejahteraan subjektif keluarga serta kualitas perkawinan. Pandemi Covid-19 memnyebabkan perubahan pada kehidupan keluarga. Kemampuan beradaptasi keluarga menentukan kualitas hidup keluarga. Penelitian ini bertujuan untuk menganalisis pengaruh antara karakteristik keluarga dan religiusitas terhadap kesejahteraan subjektif keluarga selama masa pandemi Covid-19. Penelitian ini melibatkan 100 orang ibu yang berasal dari keluarga utuh yang bekerja di sektor informal dan berdomisili di Jabodetabek. Penelitian ini menggunakan desain cross sectional study. Pemilihan contoh dilakukan secara non prbability sampling dengan teknik purposive sampling. Pengambilan data dilakukan secara online menggunakan google form Berdasarkan hasil penelitian lebih dari separuh (56%) tingkat religiusitas keluarga responden termasuk dalam kategori sedang. Sebesar lima puluh persen keluarga memiliki kesejahteraan subjektif dalam kategori tinggi. Berdasarkan analisis korelasi, lama bekerja istri per hari berhubungan negatif signifikan dengan kesejahteraan subjektif keluarga. Berdasarkan analisis regresi (Adjust R square = 0,174) artinya variabel karakteristik keluarga dan religiusitas memengaruhi kesejahteraan subjektif keluarga sebesar 17,4 persen. Variabel yang berpengaruh signifikan terhadap kesejahteraan subjektif adalah lama bekerja istri dan religiusitas.
Identifiction of Potential Regulatory Network in Colorectal with Liver Metastasis
Authors: Zhang Si-ming , Shen Cheng , Li Jing , Wang Xing-dan , Zhai Si-qiu , Shi Ling-ling , Lu Dan-li , Jiang Xiao-hui , Qiu Junlan 
Published: November 2021

Abstract
Background Liver metastasis is an important cause of death in patients with colorectal cancer(CRC). Increasing evidences indicates that microRNAs (miRNAs) are involved in the pathogenesis of colorectal with liver metastasis(CRLM). This study aims to explore potential miRNA–mRNA regulatory network. Methods The GEO database download the microarray datasets GSE56350 and GSE73178. GEO2R was used to conduct differentially expressed miRNAs (DEMs) between CRC and CRLM. The common miRNAs appeared in the two datasets. The transcription factors were predicted by FunRich and miRNet. Then, GO and KEGG pathway analysis for differentially expressed genes (DEGs) performed via DAVID. Besides, these hub genes network was used the STRING and identified by Cytoscape. Finally, the expression of the hub gene expression was used to assess by the GSE81558.Results Four DEMs were selected in the datasets. The SP1 was likely to adjust the up-regulated DEMs, however, the YY1 could regulate both up-regulated and down-regulated DEMs. The total of the 3925 genes were predicted( 3447 up-regulated DEM genes and 478 down-regulated DEM genes). These predicted genes were mainly linked to Platinum drug resistance, Cellular senescence and ErbB signaling pathway. Through the gene network construction, most of the hub genes were modulated by hsa-miR-204-5p, hsa-miR-122-5p, hsa-miR-95-3p and hsa-miR-552-3p. Among the top 20 hub genes, the expression of CREB1, RHOA and EGFR was significantly different in the GSE81558 dataset.Conclusion In this study, miRNA-mRNA in CRLM were screened between CRC patients and CRLM patients to provide a new method to predict for the pathogenesis and development of CRC.
Different Methods for Inducing Final Oocyte Maturation When Employing Progesterone-Primed Ovarian Stimulation Protocols
Authors: Sung Yen-Ju , Chen Liang-Hsuan , Chin Tzu-Hsuan , Huang Shang-Yu , Yu Hsing-Tse , Chang Chia-Lin , Huang Hong-Yuan , Wang Hsin-Shih , Soong Yung-Kuei , Wu Hsien-Ming 
Published: November 2021

Abstract
Background
Evidently, when undergoing GnRH-antagonist protocols, dual trigger has proven to produce not just better quality and quantity of oocytes but also pregnancy outcome. However, not much comparative studies have been published when PPOS protocol is used for ovarian stimulation. Can the same positive outcomes be expected after the patients have been exposed to the high level of progesterone required for PPOS protocols?
Methods
In this retrospective cohort study, patients undergoing PPOS protocols were separated into three groups based on the method employed for triggering final follicular maturation, which included: (a) human chorionic gonadotropin (hCG); (b) Gonadotropin-releasing hormone-agonist (GnRH-agonist); or (c)dual trigger (GnRH-agonist + hCG). Either in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) was utilized for fertilization. Assessment comprised of their dynamic hormone profiles, embryonic analysis, and clinical outcomes.
Results
Of the 344 recruited patients, those fulfilling the Bologna criteria as poor ovarian responders and showing Estradiol (E2)<1000 pg/ml on the day of triggering had higher oocyte maturation rate (82% vs 58%, p<0.05) when triggered with dual trigger (GnRH-agonist + hCG) than hCG alone. For the patients with E2> 6500 pg/ml on the day of triggering, none of the three triggering methods demonstrated a significant advantage regarding the number of oocytes, percentage of matured oocytes, and rate of oocytes at fertilization or cleavage stages.
Conclusions
Implementing dual trigger for stimulating final follicular maturation in patients undergoing PPOS protocols is debatable. For poor ovarian response (POR) patients, dual trigger appeared to yield higher percentage of matured oocytes. In contrast, for hyper-responders, methods of triggering oocyte maturation did not affect the percentage of matured oocytes or the qualities of the embryos. For this group of patients, therefore, the agent used should be one that would reduce the risks of ovarian hyper-stimulation syndrome (OHSS).
Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Tissue Sampling by Endoscopic Retrograde Cholangiopancreatography in Indeterminate Biliary Strictures: A Meta‑Analysis
Authors: Mi Junjie , Han Xiaofang , Wang Rong , Ma Ruijun , Zhao Danyu 
Published: November 2021

Abstract
Probe-based confocal laser endomicroscopy (pCLE), also known as optical biopsy, is a new endoscopic technique that provides real-time magnification of 1000x microscopic tissue information to diagnose indeterminate biliary strictures. Tissue sampling by endoscopic retrograde cholangiopancreatography (ERCP) is routinely performed to evaluate indeterminate biliary strictures. To evaluate the accuracy of pCLE and tissue sampling by ERCP in the diagnosis of indeterminate biliary strictures, 18 articles were included from 2008 to 2021 through Embase, PubMed, Web of Science, and Cochrane library databases. The summary estimates for the pCLE diagnosis of indeterminate biliary strictures were: sensitivity 0.88 (95% confidence interval (CI), 0.84-0.91); specificity 0.79 (95% CI, 0.74-0.83); and Diagnostic Odds Ratio (DOR) 24.63 (95% CI, 15.76-38.48). The summary estimates for tissue sampling by ERCP diagnosis for indeterminate biliary strictures were: sensitivity 0.54 (95% CI, 0.49-0.59); specificity 0.96 (95% CI, 0.94-0.98); and DOR 11.31 (95% CI 3.90-32.82). The area under the sROC curve of pCLE diagnosis of indeterminate biliary strictures is 0.90 higher than 0.65 of tissue sampling by ERCP. The pCLE is a better approach than tissue sampling by ERCP for the diagnosis of indeterminate biliary strictures by providing real-time microscopic images of the bile ducts.
Protection to Six Vaccinable Pathogens in Paired Plasma/DBS and HIV Impact in Infected and Uninfected Children From Kinshasa
Authors: Ana Rodríguez-Galet , Marina Rubio-Garrido , Ana Valadés-Alcaraz , Mario Rodríguez-Domínguez , Carlos Galán Juan , Adolphe Ndarabu , Gabriel Reina , África Holguín 
Published: November 2021

Abstract
Child vaccination reduces infant mortality rates. HIV-infected children present higher risk of diseases than non-infected. We report the protection coverage rates to 6 vaccine-preventable diseases in a paediatric population from the Democratic Republic of the Congo (DRC) and the impact of HIV infection, providing the first data on the validity of dried blood samples (DBS) to monitor the immune protection. During 2016-2018 DBS from 143 children/adolescents were collected in Kinshasa (DRC), being 52 HIV-infected. Forty-two had a paired plasma sample. Protective IgG was quantified (VirClia®IgG,Vircell) to obtain the optimal cut-off in IgG detection in DBS. ROC curves were generated with R software and statistical analyses with Stata. Protective IgG levels varied across pathogens, not reaching the herd immunity. HIV-infected presented lower vaccine protection than uninfected for all analysed pathogens, except rubella, with statistically significant differences for measles (30.8% vs. 53.8%;p=0.008) and tetanus (3.8% vs. 22%;p=0.004). New cut-offs were calculated when using DBS to improve test performance. We reinforce the necessity to increase pediatric vaccination coverage in Kinshasa, specially in HIV seropositive, with less capacity to maintain adequate antibody levels. DBS were useful to monitor vaccination coverage in seroprevalence studies in resource-limited settings, after optimizing the cut-off value for each pathogen.
Nomogram to Predict Delayed Complications in Patients with Uncomplicated Acute Type B Aortic Dissection
Authors: Liu Hanbo , Chen Jun , Feng Ri , Fang Wenbin , Liu Yi , Deng Min , Lai Jifu 
Published: November 2021

Abstract
Background
Delayed complications within the first 2 weeks in initially uncomplicated acute type B aortic dissection (uATBAD) are not scarce, which needs special attention to prevent potentially fatal complications. This study aims to develop a nomogram for estimating the probability of patients with uATBAD developing delayed complications.
Methods
The nomogram was derived from a retrospectively study of 135 patients with uATBAD from 2011 to 2021 at a single medical center. The performance of the nomogram was evaluated from discrimination, calibration, and clinical usefulness. The results were internally validated by bootstrapping.
Results
In the multivariate analysis, the independent predictors of delayed complications identified were age ≥65 years (OR, 0.320; 95%CI, 0.108-0.831; P = 0.027), C-reactive protein (OR, 1.017; 95%CI, 1.006-1.029; P = 0.003), and maximum diameter of primary entry tear (OR, 1.089; 95%CI, 1.025-1.162; P = 0.007). The prediction model was internally validated by bootstrapping and revealed good discrimination (optimism-corrected C statistic, 0.706) and good calibration (Hosmer–Lemeshow test, P = 0.6468). Decision curve analysis demonstrated that the prediction nomogram was clinically useful.
Conclusions
This study presents a nomogram based on independent predictors of clinical and morphological parameters that could help identify patients with uATBAD who might occur delayed complications and thus improve the prognosis of patients.