bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics and Efficacy of Ceftriaxone in Staphylococcal Mastitis in Crossbred Cows Following Single Intravenous Administration
Authors: Buragohain Rinku , Sar Tapas K. , Biswas Ujjwal , Samanta Indranil , Mandal Tapan K. 
Published: February 2021

Background:
Clinical mastitis is an important production disease of dairy animals, causing significant
economic losses.

Objective:
Disposition kinetics of ceftriaxone was conducted in healthy lactating and staphylococcal mastitic crossbred
cows in field condition following single-dose intravenous administration of only ceftriaxone.

Methods:
A single dose of ceftriaxone at 20 mg kg-1 body weight was administered intravenously through jugular
vein to six clinically healthy and six mastitic crossbred cows after proper diagnosis and three mastitic cows remained
untreated (positive control). Blood and milk samples were collected at 0 (pre-dosing), 5, 15, 30 min, and 1, 24, 48,
72, 96 and 120 h post drug administration and analyzed for ceftriaxone and its active metabolite (ceftizoxime) by
high-performance liquid chromatography.

Results:
Ceftriaxone achieved a peak mean plasma concentration of 131.67±1.83 μg mL-1 at 5 min, which decreased
sharply until 1 h (35.56±0.44 μg mL-1) and was below detection limit at 24 h post drug administration in mastitic
crossbred cows. On the other hand, ceftizoxime (active metabolite of ceftriaxone) achieved a peak level of
55.42±3.34 μg mL-1 at 72 h and could not be detected at 120 h post drug administration in the milk of those mastitic
crossbred cows. The Staphylococcus aureus colony count in mastitic crossbred cows was 49.33±6.55 × 105 c.f.u./mL
and the lowest colony count was achieved at 72 h with no colony at 120 h post drug administration. All the staphylococcal
mastitis affected crossbred cows were cured on day 5.

Conclusion:
Ceftriaxone may prove to be effective in the treatment of staphylococcal mastitis in crossbred cows
following single-dose intravenous administration at 20 mg kg-1 body weight.
Nutrition Therapy in Pediatric Burns
Authors: Kunduraci Yaseminergul , Garipagaoglu Muazzez 
Published: February 2021

Background:
Burns are defined as injuries resulting from exposure to thermal radiation,
electrical or chemical exposure of the skin or organic tissues. It has high mortality and morbidity
in low and middle-income countries.

Objective/Method:
The objective of this study is to evaluate the present knowledge principles of
nutritional therapy for pediatric burns from the dietician's perspective, taking into account the
epidemiology and physiology of the burn. The purpose of burn treatment is to provide survival
and tissue repair and to increase immunity. Therefore, besides fluid electrolyte replacement and
surgical interventions, nutritional therapy is quite important. Nutrition principles should aim to
reduce inflammation and meet hypermetabolic needs.

Results:
In the clinical practice of children suffering from burns, daily energy need is calculated
by adding the recommended energy expenditure to the burn percentage, but the most accurate
method is the use of indirect calorimetry. Protein requirement is around 1.5-3.0 g/kg/day. Carbohydrate
intake should be 55-60% of total energy intake, while lipids should be less than 30%. Vitamin
supplements in the form of a multivitamin are recommended in addition to vitamin A, vitamin
C, and Zinc. In cases where oral intake is insufficient, enteral nutrition should be applied as
soon as possible. When enteral feeding is contraindicated, parenteral nutrition is preferred.

Conclusion:
Evaluating the nutritional status of children and meeting macro and micronutrient
needs accelerate wound healing, shorten hospital stay, and reduce mortality.
An FT-IR Based Investigation of Trehalose Mediated Thermal Stabilisation of Bacillus clausii
Authors: Caccamo Maria T. , Magazù Salvatore 
Published: February 2021

Background:
Fourier Transform InfraRed spectroscopy analysis on Bacillus clausii and Bacillus clausii in the presence of trehalose are reported.

Objective:
In order to characterize the thermal response of such systems the InfraRed technique
was employed to collect the spectra from 25.0°C to 80.0°C in the 4000 cm-1-400 cm-1 spectral
range.

Methods:
The data analysis was performed focusing the attention to the intramolecular OH
stretching vibrational region by means evaluating the spectral distance as a function of
temperature.

Results:
From this analysis it emerges that the thermal restraint of Bacillus clausii in the presence
of trehalose is higher in respect to Bacillus clausii alone.

Conclusion:
Such a result, which confirms the bioprotective role of trehalose against external
temperature changes, provides useful information for the applications of the disaccharide in food
industry.
Особенности спектров люминесценции ZnSе &#183; О с привлечением теории антипересекающихся зон
Authors: Олешко В.И. , Вильчинская С.С. , Морозова Н.К. 
Published: February 2021

Investigations are presented in the light of the band anticrossing theory (ВАС) of the influence on the emission spectra of the structural features self-activated zinc selenide and crystals with activators.
The disunity of numerous literature data makes it difficult to understand this question. Theory-ВAС requires taking into account the influence of isoelectronic admixture of oxygen, which is invariably present in the ZnSе lattice, on the zone structure. Improvement of methods for calcu-lating the equilibrium of intrinsic point defects (STD) intendes use of these data in the analysis of the optical properties of АIIВVI, in particular zinc selenide.The aim of thе work was to re-veal the features and nature of individual luminescence bands that are widely used to obtain information on the quality of crystals.For this, the spectra of photo, cathode, pulsed lumines-cence, excitation, and stimulated emission of ZnSе are investigated in a single context with the use of these features.	Stable states of crystals with stacking faults were revealed upon introduc-tion of activators or background copper impurity.
The data are of interest for the diagnostics of crystals that are useful for creating lasers.
Evaluación del efecto de la presencia de hongos patógenos y metabolitos secundarios sobre la germinación en tres hortalizas de hojas
Authors: Álvarez-Orozco Sorianny , Torres-Rodriguez Duilio , Querales Pastora , Valera Rosario , Pacheco-Pacheco José Daniel , Gavilánez B. Tatiana 
Published: February 2021

Las semillas de hortalizas de hoja son más sensibles al ataque de patógenos, por lo que es necesario estudiar el potencial fisiológico de las misma. Para ello se evaluó la calidad fisiológica de semilla de acelga (Fordhook Giant), ajo porro (Large American Flag y American Flag) y espinaca (New Zealand y Viroflay). Para ello se determinó el porcentaje de germinación, porcentaje de emergencia (PE), velocidad de emergencia (VE), índice de velocidad de emergencia (IVE), microbiota y metabolitos secundarios por cromatografía de capa fina. Para las evaluaciones de germinación, emergencia e identificación de patógenos se realizaron 4 repeticiones usando 100 semillas por repetición. Los resultados muestran un bajo desempeño fisiológico en semillas de espinaca New Zealand y Ajo porro (Large American Flag y American Flag), lo que se vio reflejado en las variables de GE (%), PC (%), VE e IVE debido a la presencia de hongos de los géneros Rhizopus, Fusarium, Penicillium, y las bacterias, que redujeron el vigor de las plántulas, así como un número importante de plántulas anormales, mientras que las semillas de espinaca Viroflay y Acelga Fordhook Giant presentaron una mejor germinación al primer conteo, sin embargo, los problemas relacionados con el vigor se reflejaron en las variables PE, VE, IVE, y con alto desarrollo de plántulas anormales, adicionalmente se detectó la presencia de los flavonoides el cual se asoció a una menor incidencia de Penicillium sp., en la semilla de espinaca viroflay aumentando la GE en el primer conteo y la germinación total.
Acidosis tubular renal tipo 1 como consecuencia de síndrome de Sjögren. Reporte de caso clínico
Authors: Macías Argüello Christian Adrian , Orellana Orellana Carlos Andrés 
Published: February 2021

Introducción: el Síndrome de Sjögren (SS) es una alteración sistémica autoinmune inflamatoria crónica que compromete principalmente la función de las glándulas exócrinas; se caracteriza por la disminución de la función de las glándulas salivales y lagrimales. Puede haber afección renal y progresar a Acidosis Tubular Renal (ATR), pero pocos casos llegan a insuficiencia renal terminal. Objetivo: presentar el caso de una paciente con síntomas inespecíficos, en que la sospecha clínica de una ATR secundaria a un proceso sistémico hizo llegar al diagnóstico de SS. Presentación de caso: paciente femenina de 40 años que debuta con parestesias en todas las extremidades acompañadas de cefalea holocraneana, se le diagnostica desequilibrio hidroelectrolítico; es hospitalizada por disminución del nivel del sensorio, evoluciona favorablemente y es dada de alta. Un año después recae, con la misma sintomatología, más debilidad muscular en extremidades y poliartralgias. Posteriormente presenta cuadro de acidosis metabólica hiperclorémica. Se realiza interconsulta al servicio de nefrología donde se sospecha como diagnóstico presuntivo ATR tipo I. Estudios del perfil inmunológico más una prueba de Schirmer positiva llevan a la posible ATR tipo 1 secundaria al SS que fue confirmada posteriormente. Discusión: no es común poder estudiar esta evolución ya que la mayoría de pacientes evolucionan con otras complicaciones. En el caso de ATR secundaria, es importante determinar el diagnóstico de la enfermedad sistémica que la origina.2 Es importante mencionar que las pérdidas intestinales mediante diarrea o fístulas, disminuyen los niveles sistémicos de bicarbonato, por lo tanto, para un correcto diagnóstico es preciso que no se encuentren dentro de los síntomas del paciente o descartarlos como causa del desequilibrio. Conclusión: en el SS existe un 30% de compromiso extraglandular lo que encasilla como frecuente este tipo de manifestaciones, aunque el compromiso renal que lleva a insuficiencia renal terminal no lo es. Es de desear que se sigan realizando controles de las funciones de órganos extraglandulares en todos los pacientes que padezcan del SS.
Correlation Between Ultrasonic Testicular Volume and Seminal Fluid Analysis in Men with Infertility
Authors: Abu Sadiq , Kolade-Yunusa Hadijat O. , Atim Terkaa , Obakeye F. Ehimatie , Dakum Nuhu K. 
Published: February 2021

Background: Infertility is a major cause of marital disharmony in Nigeria because of the high premium placed on childbearing. Unfortunately, the blame is on the woman most times in Nigeria. Seminiferous tubules comprise 80-90% of testicular mass. Thus, the testicular volume is an index of spermatogenesis. Therefore, accurate testicular volume will help in assessing testicular function if there is no obstruction. This study was conducted to evaluate the correlation between testicular volume, measured by ultrasound and conventional sperm parameters (semen volume, sperm concentration, sperm motility and sperm morphology) in men with infertility presenting to Urology Division, University of Abuja Teaching Hospital, Gwagwalada Abuja.
Methodology: This was a descriptive cross sectional study, male subjects with infertility presenting to University of Abuja Teaching Hospital were recruited into the study. The testicular volume of all the subjects was measured by ultrasonography. The semen samples were collected by the process of masturbation on day five of sexual abstinence and analyzed according to WHO criteria 2010. Collated data were analyzed using SPSS version 20.0. P-value<0.05 was taken as statistically significant.
Results: The average total testicular volume (TTV) of men with infertility was 19.83 ml while mean testicular volume (MTV) was 10.24 ml. There was a statistically significant difference between MTV and semen volume (r=0.391, p=0.000), and sperm concentration (r=0.639, p=0.000). There was a weak and insignificant correlation between MTV and sperm motility and MTV and morphology (r=0.216, p=0.055 and r=0.076, p=0.502) respectively. Linear regression analysis showed significant impact of MTV (P<0.001) on sperm concentration with a critical MTV of ≤10ml.0 indicating poor testicular function (severe oligospermia)
Conclusion: The mean ultrasonic testicular volume in men with infertility in this study was 10.24ml and there was a significant positive correlation of MTV with semen volume and sperm concentration. Although, there was correlation of MTV with sperm motility and morphology, this was not significant. The critical mean ultrasonic testicular volume indicating poor testicular function (severe oligospermia) was found to be 10ml. This study has shown that the mean ultrasonic testicular volume can be a pointer to semen volume and sperm concentration in evaluating men with infertility.
Analisis Kesulitan Mahasiswa dalam Memahami Materi Integral Lipat Dua pada Koordinat Polar Mata Kuliah Kalkulus Lanjut
Authors: Apriandi Davi , Krisdiana Ika 
Published: February 2021

This study aims to determine the difficulties experienced by students in understanding the double integral in polar coordinates advanced calculus courses and the factors that cause these problems. This research is qualitative. Subjects were students of the fourth semester of academic year 2015/2016 Mathematics Education, IKIP PGRI Madiun totaling 3 persons. Data collection techniques have used that test, observation, interviews, and documentation. Data analysis technique conducted with qualitative data analysis, namely data reduction, data presentation and conclusion. The results were obtained five kinds of difficulties students in understanding the integral double the coordinates polar, namely 1) the difficulty in drawing a function in polar coordinates and determine the areas of integration, 2) the difficulty in converting the variable into polar coordinates, 3) difficulty in defining the limits of integration, 4) difficulty in writing a form of integration in polar coordinates, 5) difficulties in performing the calculations. Factors causing these difficulties is the ability to understand the matter is low, understanding in drawing a function in two-dimensional and three are still low, difficulties in visualizing the image of a function, do not understand the concept of comparison trigonometry, do not understand in determining the limits of integration in polar coordinates, less rigorous in setting limits of integration, not yet understand the concept of double integral in polar coordinates, lower integration calculation capabilities, yet integral mastered trigonometry.
Pembelajaran Learning Cycle 5E berbantuan Geogebra terhadap Kemampuan Pemahaman Konsep Matematis
Authors: Pratiwi Dona Dinda 
Published: February 2021

The purpose this research is to know whether there is the influence of Learning Cycle 5E model with the GeoGebra aid to understanding mathematical concepts. The type of this research is quasi-experimental research, population in this research is all students of class VII MTsN 2 Bandar Lampung as many as 10 classes with an amount of 320, sampling technique in this research using a classroom random technique where class VIIA as experiment class with Learning Cycle is learning 5E aided GeoGebra, class VIIJ as a control class with expository learning. Data analysis technique use N-Gain test and t test. Based on the result of N-Gain value analysis, the understanding of mathematical concepts in the experimental class with the use of GeoGebra application is in the medium category, that is in the experimental class there are 18 students and in the control class, there are 16 students. While the average value of N-Gain in the experimental class is 0.686 and the mean value of N-Gain in the controller class is 0.354. Based on calculations obtained t count = 6,180, so titan table, in other words, reject H0 and received H1. The conclusion that can be drawn is that there is an increase in the ability of understanding the mathematical concepts of learners in the Learning Cycle 5E class with GeoGebra in the learning process, it also shows that the application of GeoGebra has a positive influence on the improvement of the ability of understanding mathematical concepts in the learning process.
In silico characterization of human-malarial parasite species based on their DHFR and GST targets leading to a change in binding conformations of anti-malarial drugs
Authors: Shrutika Sakpal  , Alpana Bastikar  , Shanker Lal Kothari  , Virupaksha Bastikar  
Published: February 2021

In this study, we mainly focused on three anti-malarial drugs which were analyzed against the two malarial targets. Chloroquine, Mefloquine and, Proguanil was chosen as anti-malarial drugs while DHFR and GST targets from human malarial parasites like Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale, and Plasmodium vivax were considered for the study. This study was conducted to understand the sequence and structural similarity between protein DHFR and GST among four Plasmodium species as well as to find out there in silico interactions with above-stated drug candidates. There were many bioinformatics databases, tools, and software’s were run to bring out research. Our data showed not many structural differences between Plasmodium sequences but yet other characteristics of them that make them different from each other. Hence that variation has shown a difference in the binding patterns of drugs with target proteins.
Examining Gender and Resistance with Filipina Hong Kongers through Cellphilm Production and Collaborative Writing
Authors: Burkholder Casey , Soriano Jianne , Ramos-Pakit Alecxis 
Published: February 2021

Hong Kong’s non-white ethnic minorities – including its Filipina residents – are often described in media and policy discourses as a unified group. Speaking back to this misconception, in this article we describe the gendered experiences of two 23-year old Filipinas born and raised in Hong Kong through what Claudia Mitchell has described as girl method – research with girls for girls and about girls’ concerns – in our case producing visual depictions of girlhood in cellphilms (cellphone + filmmaking + intention) and collaborative writing. We write together as co-researchers to extend participatory approaches to research dissemination as we make sense of the changing political situation in Hong Kong in the years since our first collaboration in 2015. Through a polyvocal – many voices writing together – reflection on a cellphilm production project on identities and belonging four years later, we argue that Filipina identity in Hong Kong is complex and multifarious, and we aim to disseminate knowledge by and for Filipina Hong Kongers that speaks back to the erasure of their experiences within larger discourses about Filipinas, gender, and activism in Hong Kong.
Treatment outcomes of germ cell tumors of ovary: Single institutional study
Authors: Gargy Sumedha , Jha Rohit Kumar , Kushwaha Ajit Kumar , Kumar Mukunda 
Published: February 2021

5% of all ovarian tumours are accounted to germ cell tumours (GCT’s). Affecting mostly young women, the highest incidence is seen in second and third decade of life. They are highly malignant but chemosensitive and more curable than their epithelial counterparts. Treating these tumors with effective surgery and combination chemotherapy survival rates have dramatically improved in recent decades. We present our experience of ovarian germ cell tumours in theDepartment of Surgical Oncology, Rajendra Institute of Medical Sciences (RIMS), Ranchi with special emphasis on treatment outcomes. A retrospective review of hospital medical records of patients with ovarian germ cell tumours diagnosed and treated at RIMS from June 2019 to August 2020, was performed. Clinical profile and treatment outcome of patients were recorded. A total of 19 patients met criteria. The median age at diagnosis was 20 years (range 11–42 years) and all had good performance status. All except two patients underwent surgery, 70.6% and 29.4% in upfront and interval debulking surgery (IDS) setting respectively. Fertility preserving surgery was done in 75% patients in the primary surgery group and 60% undergoing IDS. 83.3% patients received BEP as adjuvant chemotherapy whereas 80% as neo-adjuvant chemotherapy. Majority (31.5%) patients had dysgerminoma as final histology, followed by mixed histology(26.3%), yolk sac tumour (15.7%), immature teratoma (15.7%) and choriocarcinoma (10.5%) 47.3% patients were in Stage I at the time of diagnosis. 78.9% patients were alive without disease, 10.5% recurred, and 10.5% were lost to follow up.
Study of the antitumor activity of the drug Dekoglitz on two tumors and some aspects of its mechanism of action
Authors: Enikeeva Zulfiya M. , Ibragimov Adil A. , Agzamova Nigora A. , Vypova Natalia L. , Saidhodjaeva Saida S. , Kholturaeva Noroj R. , Abdirova Arzayim Ch. , Tuychiev Otabek D. , Polatova Jamilya Sh. , Kadirova Dilbar A. , Salihov Faizullo S. 
Published: February 2021

Aim: Evaluation of the antitumor activity of the new drug Dekoglitz in animals with tumor strains of Sarcoma 45 in comparison with the drug dekocin, from which it was obtained, as well as with 5-fluorouracil and etoposide, and on ovarian tumors (OT) in comparison with the drug dekocin and identification of the effect of Dekoglitz on NA synthesis and internucleosomal DNA degradation. Methods: The study of preparations was carried out on 68 outbred rats with transplanted C-45 and OT tumors. The alkylating effect of the drugs was studied on cells tumor of Sarcoma 180. Results: The antitumor activity of dekoglitz on Sarcoma 45 was high, about 98/96%, with a remission rate of 80%. Its effect was 28-24% higher than that of dekocin. On OT, the effect of decoglitz with intraperitoneal administration reached 89/76% with a remission rate of 40%, with oral administration 96/86% with a remission rate of 60%. Conclusion: The study of the new drug Dekoglitz on animals with a tumor of Sarcoma 45 revealed its higher activity (by 20-27%) in comparison with the original Dekocin, 5-fluorouracil and etoposide with a lower level of side effects. On OT, the effect of Dekoglitz was 35-40% higher, especially after oral administration. Apparently, the great ability to suppress the synthesis of NA and carry out internucleosomal degradation and fragmentation of tumor DNA by the new drugs dekoglitz explains its antitumor efficacy, which is greater than that of Dekocin (K-18) in experiments on tumors.