bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of drug interaction between levetiracetam and high‐dose methotrexate in patients with lymphoma
Authors: DeFino Catherine E. , Barreto Jason N. , Pawlenty Amanda G. , Ruff Michael W. , Carabenciov Ivan D. , Mara Kristin C. , Thompson Carrie A. 
Published: March 2021

AbstractStudy ObjectiveTo determine whether there is a drug‐drug interaction precluding the concomitant use of levetiracetam and high‐dose methotrexate (HDMTX).DesignRetrospective analysis.SettingLarge academic tertiary care medical center.PatientsAdult lymphoma patients who received HDMTX as a 4‐h infusion with or without concomitant levetiracetam.Measurements and Main ResultsGeneralized estimating equations clustered on patient were used to assess each outcome. The primary outcome was the incidence of delayed MTX elimination (MTX level >1 µmol/L at 48 h). Secondary outcomes included incidence of acute kidney injury (AKI) and hospital length of stay (LOS). The 430 included patients receiving 1993 doses of HDMTX had a median (IQR) age of 66 (57.5, 72.6) years, 88 (20.5%) received concomitant levetiracetam with at least one dose of MTX, 267 (62.1%) were male, and 397 (92.3%) were Caucasian. HDMTX doses ranged from 1 to 8 g/m2. The most common lymphoma diagnoses were systemic diffuse large B‐cell lymphoma (DLBCL; 58.5%) and systemic DLBCL with central nervous system (CNS) involvement (32.8%). Rates of delayed elimination with and without levetiracetam were 13.4% and 16.3%, respectively (OR = 0.80, 95% CI 0.47–1.34, p = 0.39). AKI occurred in 15.6% and 17.0% of patients with and without concomitant levetiracetam, respectively (OR = 0.83, 95% CI 0.52–1.33, p = 0.28). The median LOS with and without levetiracetam was 4.2 and 4.1 days, respectively (p = 0.039). On multivariable analyses, only age, body surface area, diagnosis of systemic DLBCL with CNS involvement, serum creatinine, hemoglobin, total bilirubin, and dose of HDMTX were associated with delayed elimination.ConclusionsHigh‐dose methotrexate administered with concomitant levetiracetam was not associated with increased risk for delayed MTX elimination or AKI. These results support that levetiracetam and HDMTX are safe for coadministration.
Characteristics of cancer patients who died by suicide: A quantitative study of 15‐year coronial records
Authors: Men Vera Y. , Emery Clifton R. , Yip Paul S. F. 
Published: March 2021

AbstractObjectiveCancer patients have elevated suicide risk compared to the general population. However, little is known about the characteristics of cancer patients who have died by suicide. The objectives of the study were to compare the characteristics of suicide cases with, and without cancer, and determine whether age was associated with differences in characteristics.MethodsA total of 14,446 suicide cases between 2003 and 2017 in Hong Kong were identified using Coroner's Court reports. Cases were grouped by cancer status, based on medical history in the reports. Information extracted from the reports included sociodemographic variables and detailed descriptions of the suicide event. Univariate analyses and overall and subgroup multiple logistic regressions were performed to compare characteristics between the two groups.ResultsOf the 14,446 suicide cases, 1,461 (10.11%) had a cancer history. Compared to noncancer cases, cancer patients were generally older and less likely to live alone; more likely to use violent methods; less likely to have histories of physical and psychiatric problems; and more likely to communicate about their suicidal intent before death. Age was significantly associated with differences between cancer and noncancer cases.ConclusionsCancer suicide cases have different characteristics from noncancer cases. Mental health screening may not be sufficient for suicide prevention among cancer patients. Healthcare professionals and caregivers should be aware of cancer patients' suicide risk, even when there are no signs of psychiatric disturbance.
Computational study of inversion‐topomerization pathways in 1,3‐dimethylcyclohexane and 1,4‐dimethylcyclohexane: Ab initio conformational analysis
Authors: Bian Huiting , Zhang Yifan , Wang Yongjin , Zhao Jun , Ruan Xiaohui , Li Jing 
Published: March 2021

AbstractThis work concerns the special conformational behaviors for di‐substituted cyclohexanes that inherently depend on spatial orientations of side chains in flexible cyclic ring. The 1,3‐dimethylcyclohexane and 1,4‐dimethylcyclohexane in both cis‐ and trans‐configurations were focused here to unravel their inversion‐topomerization mechanisms. Full geometry optimizations were separately performed at B3LYP/6‐311++G(d,p) and MP2/6‐311++G(d,p) levels to explicitly identify all distinguishable molecular structures, and thereby the complete interconversion routes were carefully explored. Additional quantum calculations were carried out by G4 and CCSD(T)/6‐311++G(d,p) methods to acquire high‐level single point energies. With respect to quantum results, conformational analysis was conducted to study determinations, thermodynamic stabilities, and relative energies of distinct conformers. Temperature‐dependent populations of local minima for each dimethylcyclohexane were computed by Boltzmann distribution within 300–2500 K. Moreover, their unique inversion and topomerization processes were fully investigated, and potential energy surfaces were illustrated with the rigorous descriptions in two or three‐dimensional schemes for clarify.
High‐Fidelity Geometric Quantum Gates with Short Paths on Superconducting Circuits
Authors: Li Sai , Xue Jing , Chen Tao , Xue Zheng‐Yuan 
Published: March 2021

AbstractGeometric phases are robust against certain types of local noises, and thus provide a promising way toward high‐fidelity quantum gates. However, comparing with the dynamical ones, previous implementations of nonadiabatic geometric quantum gates usually require longer evolution time, due to the needed longer evolution path. Here, a scheme is proposed to realize nonadiabatic geometric quantum gates with short paths based on simple pulse control techniques, instead of deliberated pulse control in previous investigations, which can thus further suppress the influence from the environment induced noises. Specifically, the idea is illustrated on a superconducting quantum circuit, which is one of the most promising platforms for realizing practical quantum computer. As the current scheme shortens the geometric evolution path, ultra‐high gate fidelity can be obtained, especially for the two‐qubit gate case, as verified by the numerical simulation. Therefore, the protocol suggests a promising way toward high‐fidelity and robust quantum computation on a solid‐state quantum system.
Benzothiazole Encapped Silane and Its Nano Composites for Sequential Detection of Copper Ions and Cysteine in Aqueous Solution
Authors: Singh Gurjaspreet , Chowdhary Kavita , Singh Akshpreet , Satija Pinky , Shilpy  , Diksha  , Suman  , Sushma  , Mohit  
Published: March 2021

AbstractThis work describes the study of photophysical properties of triazolelinked benzothiazole based Silane (K3) and its nanoparticles (K3‐NPs). Interestingly, both K3 and K3‐NPs exhibited highly selective chemo‐sensing ablility for Cu2+ ions. The significance of N, S and triazole group in synthesized compounds for Cu2+ sensing has been confirmed by structure‐property studies. Concentration dependent colorimetric metal sensing studies indicate that Cu2+ can be detected up to 10 μM. DFT studies, colorimetric analysis, Cyclic Voltametry, absorption and emission spectroscopy techniques helped us to evaluate efficiency towards amino acids along with copper complexation.
Bi Nanoparticles Embedded in 2D Carbon Nanosheets as an Interfacial Layer for Advanced Sodium Metal Anodes
Authors: Zhang Lin , Zhu Xiaolong , Wang Guanyao , Xu Gang , Wu Minghong , Liu Hua‐Kun , Dou Shi‐Xue , Wu Chao 
Published: March 2021

AbstractSodium metal is regarded as one of the most prospective next‐generation anodes material owing to its high theoretical capacity, low redox potential, low cost, and natural abundance. Its most notable problem is the dendrite growth during Na plating/striping, which causes not only the safety concern but also the generation of inactive Na. Here, it is demonstrated that 2D carbon nanosheets embedded by bismuth nanoparticles (NPs) (denoted as Bi⊂CNs) serve as a robust nucleation buffer layer to endow the sodium metal anodes (SMAs) with high Coulombic efficiencies (CEs) and dendrite‐free deposition during long‐term cycling. The embedded Bi nanoparticles significantly reduce the nucleation barrier through the “sodiophilic” Na–Bi alloy. Meanwhile, the carbon frameworks effectively circumvent the gradual failure of those Na–Bi nucleation sites. As a result, the metallic Na on the Bi⊂CNs nucleation layer is repeatedly plated/stripped for nearly 7700 h (1287 cycles) at 3 mA h cm−2 with an average CE of 99.92%. Moreover, the Na||Na symmetric cells with the Bi⊂CNs buffer layer are stably plated/stripped for 4000 h at 1 mA cm−2 and 1 mA h cm−2. It is found that the cycling stability is closely related to the Na utilization of SMAs and current rate.
Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53
Authors: Huang Shaoping , Lu Ying , Li Suying , Zhou Tao , Wang Jing , Xia Jiangyan , Zhang Xinxin , Zhou Zuomin 
Published: March 2021

AbstractFenvalerate (Fen) is an endocrine disruptor, capable of interfering with the activity of estrogen and androgen. Our objective was to explore the molecular mechanisms of Fen on sperm in vivo. Adult male Sprague–Dawley rats were orally exposed to 0, 0.00625, 0.125, 2.5, 30 mg/kg/day Fen for 8 weeks. Sperm morphology, differential proteomics of sperm and testes, bioinformatic analysis, western blotting (WB), and RT‐PCR were used to explore the mechanism of Fen on sperm. Data showed that low Fen doses significantly induced sperm malformations. In sperm proteomics, 47 differentially expressed (DE) proteins were enriched in biological processes (BPs) related to energy metabolism, response to estrogen, spermatogenesis; and enriched in cellular components (CCs) relating to energy‐metabolism, sperm fibrous sheath and their outer dense fibers. In testicular proteomics, 56 DE proteins were highly associated with mRNA splicing, energy metabolism; and enriched in CCs relating to vesicles, myelin sheath, microtubules, mitochondria. WB showed that the expression of selected proteins was identical to their tendency in 2D gels. Literature indicates that key DE proteins in proteomic profiles (such as Trap1, Hnrnpa2b1, Hnrnpk, Hspa8, and Gapdh) are involved in P53‐related processes or morphogenesis or spermatogenesis. Also, P53 mRNA and protein levels were significantly increased by Fen; bioinformatic re‐analysis showed that 88.5% DE proteins and P53 formed a complex interacting network, and the key DE proteins were coenriched with P53‐related BPs. Results indicate that key DE proteins of proteome underlying sperm malformations of rats exposed to low Fen doses are highly related to P53.
Rapid cultivation of anammox bacteria by forming free cells in a membrane bioreactor
Authors: Li Beiying , Song Yuxin , Liu Conghe , He Yanqing , Ma Bin 
Published: March 2021

AbstractThe low growth rate of anammox bacteria is one of the main obstacles to its broad use in removing biological nitrogen in sewage treatment. Free cells show the characteristics of relatively rapid growth. To increase the growth rate, this study cultivated free‐living anammox bacteria using a membrane bioreactor. The particle size distributions showed that more than 95.48% of biomass was less than 50 μm in size, and the growth rate of free‐living anammox bacteria was shortened to 5.68 days after cultivation. Candidatus Brocadia was the most important anammox genus, with a relative abundance of 8.83%. The key functional genes, including hzs, hdh, and hao, were identified and expressed using metagenomic and metaproteomic analyses. After the rapid cultivation of the free‐living anammox bacteria, a potential method shortening the start‐up time was proposed to rapidly form anammox biofilm by attaching to carriers.Practitioner points

The free‐living anammox bacteria are cultivated in a membrane bioreactor.
More than 95.48% of biomass size is less than 50 μm.
The doubling time of these free anammox bacteria was 5.68 days.
The key functional genes of anammox bacteria were identified and expressed.
A novel method is proposed to rapidly form anammox biofilm.
Decomposition of Feynman integrals by multivariate intersection numbers
Authors: Frellesvig Hjalte , Gasparotto Federico , Laporta Stefano , Mandal Manoj K. , Mastrolia Pierpaolo , Mattiazzi Luca , Mizera Sebastian 
Published: March 2021

Abstract
We present a detailed description of the recent idea for a direct decomposition of Feynman integrals onto a basis of master integrals by projections, as well as a direct derivation of the differential equations satisfied by the master integrals, employing multivariate intersection numbers. We discuss a recursive algorithm for the computation of multivariate intersection numbers, and provide three different approaches for a direct decomposition of Feynman integrals, which we dub the straight decomposition, the bottom-up decomposition, and the top-down decomposition. These algorithms exploit the unitarity structure of Feynman integrals by computing intersection numbers supported on cuts, in various orders, thus showing the synthesis of the intersection-theory concepts with unitarity-based methods and integrand decomposition. We perform explicit computations to exemplify all of these approaches applied to Feynman integrals, paving a way towards potential applications to generic multi-loop integrals.
Elliptic quantum curves of class $$ {\mathcal{S}}_k $$
Authors: Chen Jin , Haghighat Babak , Kim Hee-Cheol , Sperling Marcus 
Published: March 2021

AbstractQuantum curves arise from Seiberg-Witten curves associated to 4d$$ \mathcal{N} $$N= 2 gauge theories by promoting coordinates to non-commutative operators. In this way the algebraic equation of the curve is interpreted as an operator equation where a Hamiltonian acts on a wave-function with zero eigenvalue. We find that this structure generalises when one considers torus-compactified 6d$$ \mathcal{N} $$N= (1,0) SCFTs. The corresponding quantum curves are elliptic in nature and hence the associated eigenvectors/eigenvalues can be expressed in terms of Jacobi forms. In this paper we focus on the class of 6d SCFTs arising from M5 branes transverse to a ℂ2/ℤksingularity. In the limit where the compactified 2-torus has zero size, the corresponding 4d$$ \mathcal{N} $$N= 2 theories are known as class$$ {\mathcal{S}}_k $$Sk. We explicitly show that the eigenvectors associated to the quantum curve are expectation values of codimension 2 surface operators, while the corresponding eigenvalues are codimension 4 Wilson surface expectation values.
Bottom-quark production at hadron colliders: fully differential predictions in NNLO QCD
Authors: Catani Stefano , Devoto Simone , Grazzini Massimiliano , Kallweit Stefan , Mazzitelli Javier 
Published: March 2021

Abstract
We report on the first fully differential calculation of the next-to-next-to-leading-order (NNLO) QCD radiative corrections to the production of bottom-quark pairs at hadron colliders. The calculation is performed by using the qT subtraction formalism to handle and cancel infrared singularities in real and virtual contributions. The computation is implemented in the Matrix framework, thereby allowing us to efficiently compute arbitrary infrared-safe observables in the four-flavour scheme. We present selected predictions for bottom-quark production at the Tevatron and at the LHC at different collider energies, and we perform some comparisons with available experimental results. We find that the NNLO corrections are sizeable, typically of the order of 25–35%, and they lead to a significant reduction of the perturbative uncertainties. Therefore, their inclusion is crucial for an accurate theoretical description of this process.
Implications of dark sector mixing on leptophilic scalar dark matter
Authors: Chakraborti Sreemanti , Islam Rashidul 
Published: March 2021

Abstract
We propose a new viable outlook to the mixing between a singlet and a doublet leptonic dark sector fields. This choice relaxes the dark matter (DM) search constraints on the quintessential scalar singlet DM as well as presents new opportunities for its detection in the lab. The mixing produces an arbitrary mass difference between the two components of the extra doublet in a gauge-invariant way, without introducing any new scale of electroweak symmetry breaking in the theory. It also provides a useful handle to distinguish between the dark sector particles of different isospins, which is a challenging task other-wise. As the dark leptons coannihilate non-trivially, the mixing effectively enhances the viable parameter space for the relic density constraint. In low DM mass regime, our analysis shows that with a non-zero mixing, it is possible to relax the existing indirect search bounds on the upper limit of the DM-Standard Model coupling. From the analysis of the $$ 3\tau +{E}_T^{\mathrm{miss}} $$
3
τ
+

E
T
miss

and $$ \mathrm{\ell}\tau +{E}_T^{\mathrm{miss}} $$
ℓ
τ
+

E
T
miss

channels for LHC at $$ \sqrt{s} $$

s

= 13 TeV, we show that one ensures the presence of the mixing parameter between the dark sector particles of the theory by looking at the peak and tail positions of the kinematic distributions. Even with a tweak in the values of other free parameters within the viable parameter region, the distinct peak and tail positions of the kinematic distributions remains a constant feature of the model. While both the channels present us the opportunity to detect the mixing signature at the LHC/HL-LHC, the former gives better results in terms of a larger region of mixing parameter. From the fiducial cross section, the projected statistical significance for the integrated luminosity, $$ \mathcal{L} $$
L
= 3 ab−1, are shown for a combined parameter region obeying all the existing constraints, where there is the best possibility to detect such a signature.
Complement to thermodynamics of dyonic Taub-NUT-AdS spacetime
Authors: Mann Robert B. , Pando Zayas Leopoldo A. , Park Miok 
Published: March 2021

Abstract
We examine the thermodynamics of Euclidean dyonic Taub-Nut/Bolt-AdS4 black holes for a variety of horizon geometries to understand how gauge field regularity conditions influence the thermodynamic relations. We find several distinct features that distinguish the NUT-charged case from its dyonic Reissner-Nordstrom counterpart. For the Nut solution, the gauge field vanishes at the horizon and so regularity is ensured. For the Bolt solution we find that the norm of the gauge field is required to vanish at the horizon in order to satisfy both regularity and the first law of thermodynamics. This regularity condition yields a constraint on the electric and magnetic charges and so reduces cohomogeneity of the system; for spherical horizons, the regularity condition removing the Misner string singularity further reduces cohomogeneity. We observe that bolt solutions with increasing electric charge have positive heat capacity, but upon turning on the magnetic charge to make the solution dyonic, we find that the properties of the uncharged one are retained, having both positive and negative heat capacity. We also study the extremal Bolt solution, finding that Misner string disappears at the horizon in the zero temperature limit. We find that the extremal solution has finite-temperature-like behaviour, with the electric potential playing a role similar to temperature.
A categorified Dold-Kan correspondence
Authors: Dyckerhoff Tobias 
Published: March 2021

AbstractIn this work, we establish a categorification of the classical Dold-Kan correspondence in the form of an equivalence between suitably defined $$\infty $$
∞
-categories of simplicial stable $$\infty $$
∞
-categories and connective chain complexes of stable $$\infty $$
∞
-categories. The result may be regarded as a contribution to the foundations of an emerging subject that could be termed categorified homological algebra.
Experimentelle Untersuchung von Einflussgrößen auf das Rasselgeräuschverhalten von Stirnrädern
Authors: Namhoff Christian , Kasten Marcel , Brimmers Jens , Brecher Christian 
Published: March 2021

ZusammenfassungDie Reduzierung von Störgeräuschen spielt eine wesentliche Rolle im Entwicklungsprozess eines Automobils. Neben dem tonalen Getriebeheulen ist das impulsartige Rasselgeräusch in der Fahrerkabine relevant. Das Getrieberasseln entsteht durch eine Drehungleichförmigkeit im Triebstrang, die durch den ungleichförmigen Verbrennungsprozess des Verbrennungsmotors aufgeprägt wird. Die Zahnflanken heben bei Überschreitung einer bestimmten Winkelbeschleunigungsamplitude voneinander ab und bewegen sich innerhalb ihres Verdrehflankenspiels, sodass Schwingungsstöße entstehen. In diesem Bericht wird die experimentelle Untersuchung der Einflüsse Anregungsfrequenz, Schleppmoment und Schmierstoff auf das Rasselgeräuschverhalten von Stirnrädern vorgestellt. Die Rasselgrenze ist durch einen signifikanten Anstieg im Körperschall- und Drehbeschleunigungspegel sowie durch Impulse im Zeitverlauf des Körperschalls und der Drehbeschleunigung zu erkennen. Die Anregungsfrequenz der Drehzahlschwankung beeinflusst die Anzahl an Verdrehflankenstößen pro Umdrehung und führt tendenziell bei einer Zunahme zu einer verringerten Rasselgrenze. Nach Überschreiten der Rasselgrenze erfolgt eine Annäherung der Körperschallpegel von aufgeprägten Drehzahlschwankungen unterschiedlicher Anregungsfrequenzen und ab einer bestimmten Drehzahlschwankungsamplitude sind die Körperschallpegel miteinander vergleichbar. Bei steigendem Schleppmoment nimmt die Drehzahlschwankungsamplitude tendenziell zu, bei welcher die Prüfverzahnung anfängt zu rasseln. Die Rasselgrenze wird durch das Schleppmoment beeinflusst – nach dem Überschreiten der Rasselgrenze weichen jedoch weder die Körperschallpegel noch die Drehbeschleunigungspegel bei unterschiedlich wirkenden Schleppmomenten signifikant voneinander ab. Der Schmierstoff zeigt bei den gewählten Versuchsparametern den höchsten Einfluss auf das Rasselgeräuschverhalten der Prüfverzahnung beim Vergleich der Schmierstoffe SAE 0W-16 und SAE 85W-90. Die Körperschallverläufe weisen im Zeitbereich bei Betrachtung der Abklingkurven bei konstanter Drehzahlschwankungsamplitude auf eine höhere Dämpfung des Schmierstoffs SAE 85W-90 mit höherer Schmierstoffviskosität hin. Der Dämpfungseffekt des Öls nimmt mit zunehmender Anregungsfrequenz bei konstanter Drehzahlschwankungsamplitude ab.
Hidden figures: epistemic costs and benefits of detecting (invisible) diversity in science
Authors: Peters Uwe 
Published: March 2021

AbstractDemographic diversity might often be present in a group without group members noticing it. What are the epistemic effects if they do? Several philosophers and social scientists have recently argued that when individuals detect demographic diversity in their group, this can result in epistemic benefits even if that diversity doesn’t involve cognitive differences. Here I critically discuss research advocating this proposal, introduce a distinction between two types of detection of demographic diversity, and apply this distinction to the theorizing on diversity in science. Focusing on ‘invisible’ diversity (i.e., differences in, e.g., LGBTQ+, religious, or political orientation), I argue that in one common kind of group in science, if group members have full insight into their group’s diversity, this is likely to create epistemic costs. These costs can be avoided and epistemic benefits gained if group members only partly detect their group’s diversity. There is thus an epistemic reason for context-dependent limitations on scientists’ insight into the diversity of their group.