bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Strategi Marketing Bagi Pelaku UMKM Kota Bogor
Authors: Mashadi Mashadi , Suardy Weman 
Published: April 2021

Tujuan diadakannya Peningkatan Strategi Marketing bagi pelaku UMKM Kota Bogor adalah untuk Memberi motivasi dan semangat kepada pelaku UMKM untuk melakukan wirausaha serta Meningkatkan kreativitas dan inovasi para pelaku UMKM. Metode pelaksanaan yang dilakukan adalah mengenalkan dan menjelaskan pemahaman tentang digital marketing, memberikan cara yang tepat dalam memasarkan produk dan jasa di era digital, memberikan pemahaman untuk dapat menganalisa produk pesaing. Melalui kegiatan ini, diharapkan partisipan dapat menjadi pelaku UMKM yang sukses baik ditingkat lokal Kota Bogor maupun Internasional.

Kata kunci: strategi marketing
Results and adverse effect evaluations in localized prostate cancer patients undergoing intensity modulated radiotherapy with tomotherapy
Authors: ÖZTÜRK Gül Ayşen , OZTURK Murat 
Published: April 2021

Aim
To assess the dosimetric results and early and late adverse effects of radiotherapy with tomotherapy in localized prostate cancer patients.
Materials and Methods
Treatment results and early and late adverse effects in 60 patients who had undergone curative radiotherapy due to prostate cancer and who had been followed-up for at least 6 months in the post-treatment process were assessed retrospectively. 28 of the patients were in the low-intermediate risk group, whereas 32 of them were in the high-risk group. 74 Gy radiotherapy was delivered to the prostate with simultaneous integrated boost strategy, 60 Gy to seminal vesicles and 52 Gy to pelvic lymph nodes of the cases. Patients with at least 6 months of post-treatment follow-up were assessed in terms of early and late adverse effects.
Results
Twenty patients had grade 1 and two patients had grade 2 acute genitourinary toxicity, whereas 15 patients had grade 1 and 4 patients had grade 2 acute gastrointestinal toxicity. Twelve patients had grade 1 and 3 patients had grade 2 late genitourinary toxicity, 6 patients had grade 1 and two other patients had grade 2 and grade 3 late gastrointestinal toxicity. Biochemical recurrence developed in four patients. One of the patients with recurrence died in the 14th month of recurrence due to organ metastasis.
Conclusions
Image-guided dose-escalated radiotherapy with IMRT technique is a reliable method in prostate cancer treatment. Increased toxicity was not observed in the cases with lymph node irradiation despite the increased radiotherapy field.
Prevalence of Hepatitis B virus serological groups in rheumatoid arthritis and association of previous hepatitis B virus infection with demographic data and parenteral therapies
Authors: AYAR Koray , ASAN Ali , ONART Orhan , TÜRK Mert , DEMIRAY Tulay Dilara 
Published: April 2021

Introduction: The aim of this study is to determine the frequency of Hepatitis b virus (HBV) serological groups in Rheumatoid arthritis (RA) and to compare the demographic characteristics and frequency of parenteral therapies between patient groups with and without previous HBV infection.
Methods: Charts of RA patients were examined retrospectively. HBsAg, anti-HBc IgG, and anti-HBs test results were screened. All participants were divided into 3 serological groups (patients naive to HBV infection, previous HBV infection, vaccinated). Those with previous HBV infection were further divided into 3 serological subgroups (naturally immune, anti-HBc IgG positive only, chronic HBV infection). Findings were compared between RA patients with and without previous HBV infection.
Results: Four hundred and fifty-one patients (female/male: 343/108) were included. The prevalence of patients naive to HBV infection, with previous HBV infection and vaccinated were 59.4%, 33.7%, and 6.9%, respectively. The prevalence of patients with naturally immune, anti-HBc IgG positive only, and chronic HBV infection were 25.7%, 4.4%, and 3.5%, respectively. Age in RA patients with and without previous HBV infection was 60.8±12.4 and 56.7±14.2 years, respectively(p
Multi-compartment kinetic–allometric (MCKA) model of radionuclide bioaccumulation in marine fish
Authors: Bezhenar Roman , Kim Kyeong Ok , Maderich Vladimir , de With Govert , Jung Kyung Tae 
Published: April 2021

Abstract. A model of the radionuclide accumulation in fish taking into account the contribution of different tissues and allometry is presented.
The basic model assumptions are as follows.
(i) A fish organism is represented by several compartments in which radionuclides are homogeneously distributed.
(ii) The compartments correspond to three groups of organs or tissues: muscle, bones and organs (kidney, liver, gonads, etc.) differing in metabolic function.
(iii) Two input compartments include gills absorbing contamination from water and digestive tract through which contaminated food is absorbed.
(iv) The absorbed radionuclide is redistributed between organs or tissues according to their metabolic functions.
(v) The elimination of assimilated elements from each group of
organs or tissues differs, reflecting differences in specific
tissues or organs in which elements were accumulated.
(vi) The food and water uptake rates, elimination rate, and growth rate depend on the metabolic rate, which is scaled by fish mass to the 3/4 power.
The analytical solutions of the system of model equations describing dynamics of the assimilation and elimination of 134Cs, 57Co, 60Co, 54Mn and 65Zn, which are preferably accumulated in different tissues, exhibited good agreement with the laboratory experiments.
The developed multi-compartment kinetic–allometric model was embedded into the box model POSEIDON-R (Maderich et al., 2018b), which describes transport of radionuclides in water, accumulation in the sediment and transfer of radionuclides through the pelagic and benthic food webs.
The POSEIDON-R model was applied for the simulation of the transport and fate of 60Co and 54Mn routinely released from Forsmark Nuclear Power Plant (NPP) located on the Baltic Sea coast of Sweden and for calculation of 90Sr concentration in fish after the accident at Fukushima Dai-ichi NPP.
Computed concentrations of radionuclides in fish agree with the measurements much better than calculated using standard whole-body model and target tissue model. The model with the defined generic parameters could be used in different marine environments without calibration based on a posteriori information, which is important for emergency decision support systems.
Correlation Between Age of Stroke Patients and Mental Imagery to Improve Hand Function
Authors: Mubeen Iqra , Afzal Waqar 
Published: April 2021

Mental imagery is the rehearsal of a physical task mentally, without execution of any physical task. The technique triggers the similar neurons (mirror neurons) of brain as are triggered by physical performance of the task.
Objective: To find correlation between age of stroke patients and mental imagery to improve hand function.Methodology: A sample of 50 patients was selected from DHQ hospital Jhelum. The inclusion criteria were as follows; age 55-75, gender (male and female), and stroke duration more than 12 months. Patients of age below 55 and above 75, patients with parietal stroke were excluded from study. Patients were treated with mental imagery technique for 10 weeks, P<0.05.Results: Both male and females were included in study. Sample consisted of 67% females and 33% male. Mean age of participants was 56.42 + 1.36. WMFT was used as outcome measure. Post treatment mean WMFT score was 57.9. Pearson Correlation was used to find out correlation between age and mental imagery outcome.
Conclusions: It was concluded that no correlation is present between age and mental imagery ability of older adult stroke patients. Older adults were benefited with mental imagery technique and a significant improvement in hand function ofstroke patients was found.
Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC
Authors: Ipsen Johan Ø. , Hernández‐Rollán Cristina , Muderspach Sebastian J. , Brander Søren , Bertelsen Andreas B. , Jensen Poul Erik , Nørholm Morten H. H. , Lo Leggio Leila , Johansen Katja S. 
Published: April 2021

The histidine brace (His‐brace) is a copper‐binding motif that is associated with both oxidative enzymes and proteinaceous copper chaperones. Here, we used biochemical and structural methods to characterize mutants of a His‐brace‐containing copper chaperone from Pseudomonas fluorescens (PfCopC). A total of 15 amino acid variants in primary and second‐sphere residues were produced and characterized in terms of their copper binding and redox properties. PfCopC has a very high affinity for Cu(II) and also binds Cu(I). A high reorganization barrier likely prevents redox cycling and, thus, catalysis. In contrast, mutations in the conserved second‐sphere Glu27 enable slow oxidation of ascorbate. The crystal structure of the variant E27A confirmed copper binding at the His‐brace. Unexpectedly, Asp83 at the equatorial position was shown to be indispensable for Cu(II) binding in the His‐brace of PfCopC. A PfCopC mutant that was designed to mimic the His‐brace from lytic polysaccharide monooxygenase‐like family X325 did not bind Cu(II), but was still able to bind Cu(I). These results highlight the importance of the proteinaceous environment around the copper His‐brace for reactivity and, thus, the difference between enzyme and chaperone.
Paper‐Based Microfluidic Devices
Authors: Gao Bingbing 
Published: April 2021

Abstract
With many merits such as low cost, porosity, flexibility, and self‐infiltration, paper has become one of the widely‐used substrates, especially in building microfluidic chips for point‐of‐care testing (POCT). This article introduces microfluidic devices built with traditional papers, including fabrication, detection methods, and applications.
Poly(catecholamine) Coated CsPbBr3 Perovskite Microlasers: Lasing in Water and Biofunctionalization
Authors: Cho Sangyeon , Yun Seok Hyun 
Published: April 2021

AbstractLead halide perovskite (LHP) is a promising material for various optoelectronic applications. Surface coating on particles is a common strategy to improve their functionality and environmental stability, but LHP is not amenable to most coating chemistries because of its intrinsic weakness against polar solvents. Here, a novel method of synthesizing LHP microlasers in a super‐saturated polar solvent using sonochemistry and applying various functional coatings on individual microlasers in situ is described. Cesium lead bromine perovskite (CsPbBr3) microcrystals, capped with organic poly‐norepinephrine (pNE) layers, are synthesized. The catechol group of pNE coordinates to bromine‐deficient lead atoms, forming a defect‐passivating and diffusion‐blocking shell. The pNE layer enhances the material lifetime of CsPbBr3 in water by 2000‐fold, enabling bright luminescence and lasing from single microcrystals in water. Furthermore, the pNE shell permits biofunctionalization with proteins, small molecules, and lipid bilayers. Luminescence from CsPbBr3 microcrystals is sustained in water over 1 h and observed in live cells. The functionalization method may enable new applications of LHP laser particles in water‐rich environments.
An Ultrafast Nonvolatile Memory with Low Operation Voltage for High‐Speed and Low‐Power Applications
Authors: Zhang Zhi‐Cheng , Li Yuan , Li Jiaqiang , Chen Xu‐Dong , Yao Bei‐Wei , Yu Mei‐Xi , Lu Tong‐Bu , Zhang Jin 
Published: April 2021

AbstractMemory plays a vital role in modern information society. High‐speed and low‐power nonvolatile memory is urgently demanded in the era of big data. However, ultrafast nonvolatile memory with nanosecond‐timescale operation speed and long‐term retention is still unavailable. Herein, an ultrafast nonvolatile memory based on van der Waals heterostructure is proposed, where a charge‐trapping material, graphdiyne (GDY), serves as the charge‐trapping layer. With the band‐engineered heterostructure and excellent charge‐trapping capability of GDY, charges are directly injected into the GDY layer and are persistently captured by the trapping sites in GDY, which result in an ultrafast writing speed (8 ns), a low operation voltage (30 mV), and a long retention time (over 104 s). Moreover, a high on/off ratio of 106 is demonstrated by this memory, which enables the achievement of multibit storage with 6 discrete storage levels. This device fills the blank of ultrafast nonvolatile memory technology, which makes it a promising candidate for next‐generation high‐speed and low‐power‐consumption nonvolatile memory.
Effect of Hydrogen Bonding on a Value of an Open Circuit Potential of Poly‐(3,4‐ethylenedioxythiophene) as a Beneficial Mode for Energy Storage Devices
Authors: Ivanko Iryna , Tomšík Elena 
Published: April 2021

AbstractPoly(3,4‐ethylenedioxythiophene) is one of the semiconducting polymers that has attracted attention as electroactive materials for many different applications such as electrochromic devices, light‐emitting diodes, biosensors, and supercapacitors. The fundamental understanding of the origin of its energy storage ability will lead to the proper design of such devices. Generally, the charge storage in supercapacitors is due to the formation of an electrical double layer and/or redox reactions. Recently, it is shown that the formation of cation radicals in PEDOT is induced by the hydrogen‐bond formation between formic acid and polymer during electrochemical polymerization. The induced cation radicals play a major role in the charge storage ability of PEDOT, as studied in the current work. Furthermore, the presence of hydrogen bonds in PEDOT leads to the stable in time open circuit potential of 900 mV. This new knowledge leads to the designing of a symmetrical supercapacitor based on PEDOT as active material where hydrogen‐bonds play a crucial role in the improved performance of the device.
A unified framework to experiment with algorithm optimality and efficiency
Authors: Velázquez‐Iturbide J. Ángel 
Published: April 2021

AbstractIt is common in algorithm courses to assess the correctness of algorithms via testing as well as conducting experiments to measure their run‐time performance. However, two severe problems must be addressed: both activities are conducted using different procedures and tools, and algorithm assessment systems do not support well optimization problems due to their unique characteristics. Given the relevant role of optimization algorithms in computing, we present a unified framework to support experimentation with both criteria, that is, optimality and efficiency. The contributions of the article are twofold. First, we present a unified framework to experiment with both criteria, by using explicit principles and by presenting its instantiation in the AlgorEx system. The homogeneous treatment of optimality and time efficiency contributes to smoother integration of experimentation into a course syllabus and to easier adoption of the system. Second, we present our experience in several academic years in an algorithm course. Initially, it was noticed that students had severe difficulties dealing with experimentation, but their academic performance sharply increased by fully integrating experimentation along the complete course. The article also identifies some opportunities for extension in AlgorEx.
Formation and stability of oil‐laden foam: Effect of surfactant and hydrocarbon solvent
Authors: Lin Feng , Ng Jason K. , Huang Yueying , Huang Charley , Zeng Hongbo 
Published: April 2021

AbstractOil‐laden (OL) foams could serve an important role in various processes, particularly in enhanced oil recovery; however, OL foams are less studied than aqueous foams. In this work, the formation and stability of OL foam, by either sodium dodecyl sulphate (SDS) or Triton X‐100 (TX‐100) in water‐pentane mixture, was evaluated. We first constructed a diagram of good and poor foaminess against pentane content in the mixture and aqueous surfactant concentration. It was shown that surfactant onset concentration for good foaming was increased with increasing pentane content. The result was fitted using a mathematical model that considers the surfactant dilution and adsorption effects by pentane. Foam height decay profiles were also monitored. Results indicated that SDS resulted in a more stable foam than TX‐100 at the same critical micelle concentration (CMC). Depending on surfactant concentration, OL foams exhibited strikingly different stability behaviours. Pentane acted as an anti‐foamer at surfactant concentrations at the CMC or lower. However, very high foam stability was displayed at high surfactant concentration (e.g., 3× CMC) and medium to high pentane contents; this is a result contradictory to the predication of entering, spreading, and bridging coefficients in the classic theory. The stable OL foams of this study could be attractive to potential foam applications.
Gene and transgenics nomenclature for the laboratory axolotl—Ambystoma mexicanum
Authors: Nowoshilow Sergej , Fei Ji‐Feng , Voss S. Randal , Tanaka Elly M. , Murawala Prayag 
Published: April 2021

AbstractThe laboratory axolotl (Ambystoma mexicanum) is widely used in biological research. Recent advancements in genetic and molecular toolkits are greatly accelerating the work using axolotl, especially in the area of tissue regeneration. At this juncture, there is a critical need to establish gene and transgenic nomenclature to ensure uniformity in axolotl research. Here, we propose guidelines for genetic nomenclature when working with the axolotl.
Drebrin, an actin‐binding protein, is required for lens morphogenesis and growth
Authors: Karnam Shruthi , Maddala Rupalatha , Stiber Jonathan A. , Rao Ponugoti V. 
Published: April 2021

AbstractBackgroundLens morphogenesis, architecture, and clarity are known to be critically dependent on actin cytoskeleton organization and cell adhesive interactions. There is limited knowledge, however regarding the identity and role of key proteins regulating actin cytoskeletal organization in the lens. This study investigated the role of drebrin, a developmentally regulated actin‐binding protein, in mouse lens development by generating and characterizing a conditional knockout (cKO) mouse model using the Cre‐LoxP recombination approach.ResultsDrebrin E, a splice variant of DBN1 is a predominant isoform expressed in the mouse lens and exhibits a maturation‐dependent downregulation. Drebrin co‐distributes with actin in both epithelium and fibers. Conditional deficiency (both haploinsufficiency and complete absence) of drebrin results in disrupted lens morphogenesis leading to cataract and microphthalmia. The drebrin cKO lens reveals a dramatic decrease in epithelial height and width, E‐cadherin, and proliferation, and increased apoptotic cell death and expression of α‐smooth muscle actin, together with severely impaired fiber cell organization, polarity, and cell‐cell adhesion.ConclusionsThis study demonstrates the requirement of drebrin in lens development and growth, with drebrin deficiency leading to impaired lens morphogenesis and microphthalmia.
Myelocytomatosis‐Protein Arginine N‐Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma
Authors: Luo Yuhong , Gao Yuqing , Liu Weiwei , Yang Yuan , Jiang Jie , Wang Ying , Tang Wei , Yang Shoumei , Sun Lulu , Cai Jie , Guo Xiaozhen , Takahashi Shogo , Krausz Kristopher W. , Qu Aijuan , Chen Lei , Xie Cen , Gonzalez Frank J. 
Published: April 2021

Background and Aims
HCC is a leading cause of cancer‐related deaths globally with poor outcome and limited therapeutic options. Although the myelocytomatosis (MYC) oncogene is frequently dysregulated in HCC, it is thought to be undruggable. Thus, the current study aimed to identify the critical downstream metabolic network of MYC and develop therapies for MYC‐driven HCC.

Approach and Results
Liver cancer was induced in mice with hepatocyte‐specific disruption of Myc and control mice by administration of diethylnitrosamine. Liquid chromatography coupled with mass spectrometry‐based metabolomic analyses revealed that urinary dimethylarginine, especially symmetric dimethylarginine (SDMA), was increased in the HCC mouse model in an MYC‐dependent manner. Analyses of human samples demonstrated a similar induction of SDMA in the urines from patients with HCC. Mechanistically, Prmt5, encoding protein arginine N‐methyltransferase 5, which catalyzes SDMA formation from arginine, was highly induced in HCC and identified as a direct MYC target gene. Moreover, GSK3326595, a PRMT5 inhibitor, suppressed the growth of liver tumors in human MYC‐overexpressing transgenic mice that spontaneously develop HCC. Inhibition of PRMT5 exhibited antiproliferative activity through up‐regulation of the tumor suppressor gene Cdkn1b
/p27, encoding cyclin‐dependent kinase inhibitor 1B. In addition, GSK3326595 induced lymphocyte infiltration and major histocompatibility complex class II expression, which might contribute to the enhanced antitumor immune response. Combination of GSK3326595 with anti–programed cell death protein 1 (PD‐1) immune checkpoint therapy (ICT) improved therapeutic efficacy in HCC.

Conclusions
This study reveals that PRMT5 is an epigenetic executer of MYC, leading to repression of the transcriptional regulation of downstream genes that promote hepatocellular carcinogenesis, highlights a mechanism‐based therapeutic strategy for MYC‐driven HCC by PRMT5 inhibition through synergistically suppressed proliferation and enhanced antitumor immunity, and finally provides an opportunity to mitigate the resistance of “immune‐cold” tumor to ICT.
Reading School: Critical Literacies of the Youth Equity Agents
Authors: Hendrix-Soto Aimee 
Published: April 2021

AbstractIn this article, I focus on the critical literacies of Black and Latinx youth participating in a youth participatory action research project, as well as the pedagogies that engaged those literacies. Critical ethnographic study of the Youth Equity Agents’ literacy practices revealed that they enacted a practice of reading school, wherein they investigated and acted on racial injustices in their local school worlds. Although youth had clearly been investigating injustice as a part of their daily navigations of urban schooling, this practice was engaged and extended in the youth participatory action research project. A pedagogical approach that positioned youth as knowledge producers and centered their social interests facilitated this, as did specific teaching practices such as engaging social theory and exploring the material environments of school. Youth applied this learning to produce digital photo counternarratives with the potential to transform inequity in schooling.