bluuebunny/crossref_metadata_2025_split huggingface dataset:
LRRK2 Gene Variants Associated With a Higher Risk for Alcohol Dependence in Multiethnic Populations
Authors: Oliveira Pablo Rafael Silveira , de Matos Lorena Oliveira , Araujo Nathalia Matta , Sant Anna Hanaísa P. , da Silva e Silva Daniel Almeida , Damasceno Andresa K. Andrade , Martins de Carvalho Luana , Horta Bernardo L. , Lima-Costa Maria Fernanda , Barreto Mauricio Lima , Wiers Corinde E. , Volkow Nora D. , Brunialti Godard Ana Lúcia 
Published: May 2021

Background:Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement ofLRRK2in alcohol dependence (AD).LRRK2expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate the association of variants in theLRRK2gene with AD in multiethnic populations from South and North America.Methods:Alcohol-screening questionnaires [such as CAGE and Alcohol Use Disorders Identification Test (AUDIT)] were used to determine individual risk of AD. Multivariate logistic regression analyses were done in three independent populations (898 individuals from Bambuí, Brazil; 3,015 individuals from Pelotas, Brazil; and 1,316 from the United States). Linkage disequilibrium and conditional analyses, as well asin silicofunctional analyses, were also conducted.Results:FourLRRK2variants were significantly associated with AD in our discovery cohort (Bambuí): rs4768231, rs4767971, rs7307310, and rs1465527. Two of these variants (rs4768231 and rs4767971) were replicated in both Pelotas and US cohorts. The consistent association signal (at theLRRK2locus) found in populations with different genetic backgrounds reinforces the relevance of our findings.Conclusion:Taken together, these results support the notion that genetic variants in theLRRK2locus are risk factors for AD in humans.
First-Episode Patients Report Cognitive Difficulties in Executive Functioning 1 Year After Initial Episode of Major Depressive Disorder
Authors: Schmid Marit , Hammar Åsa 
Published: May 2021

Objective: Major Depressive Disorder (MDD) is associated with cognitive impairment in general, and Executive Functioning (EF) in particular, even in remitted phase of the disorder, suggesting residual cognitive symptoms. The aim of the present study was to investigate self-reported EF 1 year after the first episode of MDD and to explore this in relation to depressive mood symptoms, remission and relapse.Method: The study included data from 24 patients and 23 healthy control subjects 1 year after the patients' initial first episode of MDD. All participants completed the Behavior Rating Inventory of Executive Functioning-Adult version (BRIEF-A), a standardized self-report measure of perceived EF in everyday life, measuring nine different EF. Total index scores for metacognitive functions, behavior/emotional regulation functions and a global EF score is also calculated.Results: The patient group in total, independent of symptom status, reported significantly lower EF in all indexes compared to the healthy controls 1 year after the initial episode. However, higher depressive mood symptom load correlated with self-reported difficulties in metacognitive functions and poor global EF scores. Regulatory control of behavior and emotional responses did not show such strong association with mood symptoms, but low self-report scores on this measure was associated with relapse during the first year after the initial episode.Conclusion: First-episode patients report significant lower executive functioning in everyday life compared to individually matched healthy controls, 1 year after onset, independent of symptom load. Residual cognitive symptoms seem to be evident and associated with risk of relapse and should be targeted in treatment and prevention of recurrence in MDD.
Prevalence of Mental Disorders and Impact on Quality of Life in Patients With Pulmonary Arterial Hypertension
Authors: Olsson Karen M. , Meltendorf Tanja , Fuge Jan , Kamp Jan C. , Park Da-Hee , Richter Manuel J. , Gall Henning , Ghofrani Hossein A. , Ferrari Pisana , Schmiedel Ralf , Kulla Hans-Dieter , Heitland Ivo , Lepsy Nicole , Dering Madelaine-Rachel , Hoeper Marius M. , Kahl Kai G. 
Published: May 2021

Objective: Mental health may affect the quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). However, mental disorders have not been systematically assessed in these patients. We examined the prevalence of mental disorders using structured interviews and determined their impact on QoL in patients with PAH.Methods: This study included 217 patients with PAH from two German referral centers. Psychiatric disorders were assessed using the structured clinical interview for DSM-V. QoL was assessed using the WHO Quality of Life questionnaire (short form). The diagnostic value of the Hospital Anxiety and Depression Scale was evaluated by receiver operating characteristic curve analysis.Results: More than one third of the patients had psychological disorders with current or past adjustment disorder (38.2%), current major depressive disorder (23.0%), and panic disorder (15.2%) being the most prevalent mental illnesses. About half of the patients with a history of adjustment disorder developed at least one other mental illness. The presence of mental disorders had a profound impact on QoL. The Hospital Anxiety and Depression Scale ruled out panic disorder and depression disorder with negative predictive values of almost 90%.Conclusion: Mental disorders, in particular adjustment disorder, major depression, and panic disorder, are common in patients with PAH and contribute to impaired QoL in these patients. The Hospital Anxiety and Depression Scale may be used as a screening tool for the most common mental health disorders. Future studies need to address interventional strategies targeting mental disorders in patients with PAH.
Analysis of Media Outlets on Women's Health: Thematic and Quantitative Analyses Using Twitter
Authors: Alvarez-Mon Miguel A. , Donat-Vargas Carolina , Llavero-Valero Maria , Gea Alfredo , Alvarez-Mon Melchor , Martinez-Gonzalez Miguel A. , Lopez-del Burgo Cristina 
Published: May 2021

Background: Media outlets influence social attitudes toward health habits. The analysis of tweets has become a tool for health researchers.Objective: The objective of this study was to investigate the distribution of tweets about women's health and the interest generated among Twitter users.Methods: We investigated tweets posted by 25 major U.S. media outlets about pre-menopausal and post-menopausal women's health between January 2009 and December 2019 as well as the retweets generated. In addition, we measured the sentiment analysis of these tweets as well as their potential dissemination.Results: A total of 376 tweets were analyzed. Pre-menopausal women's health accounted for most of the tweets (75.3%). Contraception was the main focus of the tweets, while a very limited number were related to infertility (1.4%). With regard to medical content, the effectiveness of contraceptive methods was the most frequent topic (46.2%). However, tweets related to side effects achieved the highest retweet-to-tweet ratio (70.3). The analysis of sentiments showed negative perceptions on tubal ligation.Conclusions: The U.S. media outlets analyzed are more interested in pre-menopausal than in post-menopausal women health and focused their content on contraception, while Twitter users showed greater interest in side effects.
Evolution or Revolution? Recommendations to Improve the Swiss Health Data Framework
Authors: Martani Andrea , Geneviève Lester Darryl , Egli Sophia Mira , Erard Frédéric , Wangmo Tenzin , Elger Bernice Simone 
Published: May 2021

Background: Facilitating access to health data for public health and research purposes is an important element in the health policy agenda of many countries. Improvements in this sense can only be achieved with the development of an appropriate data infrastructure and the implementations of policies that also respect societal preferences. Switzerland is a revealing example of a country that has been struggling to achieve this aim. The objective of the study is to reflect on stakeholders' recommendations on how to improve the health data framework of this country.Methods: We analysed the recommendations collected as part of a qualitative study including 48 expert stakeholders from Switzerland that have been working principally with health databases. Recommendations were divided in themes and subthemes according to applied thematic analysis.Results: Stakeholders recommended several potential improvements of the health data framework in Switzerland. At the general level of mind-set and attitude, they suggested to foster the development of an explicit health data strategy, better communication and the respect of societal preferences. In terms of infrastructure, there were calls for the creation of a national data center, the improvement of IT solutions and the use of a Unique Identifier for patient data. Lastly, they recommended harmonising procedures for data access and to clarify data protection and consent rules.Conclusion: Recommendations show several potential improvements of the health data framework, but they have to be reconciled with existing policies, infrastructures and ethico-legal limitations. Achieving a gradual implementation of the recommended solutions is the preferable way forward for Switzerland and a lesson for other countries that are also seeking to improve health data access for public health and research purposes.
The COSMO-Spain Survey: Three First Rounds of the WHO Behavioral Insights Tool
Authors: Rodríguez-Blázquez Carmen , Romay-Barja María , Falcón María , Ayala Alba , Forjaz Maria João 
Published: May 2021

Objective: To describe changes in knowledge, attitudes and preventive practices (KAP), risk perception, and psychological variables of Spanish population toward the COVID-19 pandemic from July to November 2020.Methods: Three samples, each of one composed by 1,000+ persons aged 18 years or older, were interviewed online in three rounds, every 2 months, from July to November 2020.Results: The level of knowledge on COVID-19 was high in the three rounds, with percentages above 95% of correct answers related to ways of contagion and correct use of face masks. The most accepted measure was the mandatory use of face masks (80–86% of agreement in the three rounds, p = 0.001), followed by the night curfew (63% of agreement). Most participants (&gt;80%) consistently reported using face masks, ventilating spaces, and washing or disinfecting hands. However, risk perception and self-efficacy were low. Worry about losing a loved one, the health system overload and people who do not wear face masks was high (&gt;85% of the samples). The percentage of respondents who felt depressed due to COVID-19 increased from round 1 to round 3 (p = 0.044).Conclusions: Spanish population has a high degree of KAP, but a relatively low risk perception and self-efficacy. These findings can help health authorities to guide containment measures and campaigns addressed to improve preventive practices.
Canadian High School Rugby Coaches Readiness for an Injury Prevention Strategy Implementation: Evaluating a Train-the-Coach Workshop
Authors: Shill Isla J. , Räisänen Anu , Black Amanda M. , Barden Craig , van den Berg Carla , McKay Carly D. , West Stephen W. , Pasanen Kati , Hagel Brent E. , Emery Carolyn A. 
Published: May 2021

Background: Canadian rugby coach injury prevention beliefs and attitudes have not been studied, yet are key to informing injury prevention strategy implementation. Despite neuromuscular training (NMT) warm-up success in reducing injury, adoption of these programs is variable. Therefore, objectives of this study included (1) describing Canadian youth rugby coach injury prevention beliefs and attitudes and current warm-up practices and (2) evaluating intention to use a rugby-specific NMT warm-up.Methods: High school rugby coaches completed a questionnaire before and after a rugby-specific NMT warm-up workshop. The pre-workshop questionnaire captured demographics, current warm-up practice, and NMT warm-up knowledge and use. Both questionnaires captured injury prevention beliefs, attitudes and behavioral intention.Results: Forty-eight coaches participated in the workshops. Pre-workshop, 27% of coaches were aware of NMT warm-ups. Coaches primarily included aerobic and stretching components, while balance components were not common in their warm-ups over the past year. Additionally, 92% of coaches agreed to some extent they would “complete a rugby-specific warm-up program prior to every game and training session this season.” Post-workshop, 86% of coaches agreed to some extent that they would use the program in every rugby session. No differences were observed between pre- and post-workshop intention to implement the warm-up (p = 0.10).Interpretation: This is the first study to examine current Canadian youth rugby coach warm-up practices and intention to use NMT warm-ups. Canadian rugby coach intention to use a rugby-specific NMT warm-up is high, providing ample opportunity to investigate the efficacy of a NMT warm-up in youth rugby.
New Cubic B-Spline Approximation for Solving Linear Two-Point Boundary-Value Problems
Authors: Latif Busyra , Abdul Karim Samsul Ariffin , Hashim Ishak 
Published: May 2021

In this study, we introduce a new cubic B-spline (CBS) approximation method to solve linear two-point boundary value problems (BVPs). This method is based on cubic B-spline basis functions with a new approximation for the second-order derivative. The theoretical new approximation for a second-order derivative and the error analysis have been successfully derived. We found that the second-order new approximation was O(h3) accurate. By using this new second-order approximation, the proposed method was O(h5) accurate. Four numerical problems consisting of linear ordinary differential equations and trigonometric equations with different step sizes were performed to validate the accuracy of the proposed methods. The numerical results were compared with the least squares method, finite difference method, finite element method, finite volume method, B-spline interpolation method, extended cubic B-spline interpolation method and the exact solutions. By finding the maximum errors, the results consistently showed that the proposed method gave the best approximations among the existing methods. We also found that our proposed method involved simple implementation and straightforward computations. Hence, based on the results and the efficiency of our method, we can say that our method is reliable and a promising method for solving linear two-point BVPs.
Análise espacial e temporal dos focos de calor no município de Anapu, Pará / Spatial and temporal analysis of fire focuses in the city of Anapu, Pará
Authors: Dos Santos Gabriel Garreto , De Araújo Rejane Gonçalves , Neris João Paulo Ferreira , De Sousa Jameles Silva , Da Silva Bruna Kaely Souza , Silva Valeria de Sousa , De Freitas Tatiana Pará Monteiro 
Published: May 2021

O presente artigo objetivou identificar os principais focos de queimadas no município de Anapu, Pará, nos anos de 2014 a 2019 e contribuir para a discussão sobre a avaliação espacial e temporal das queimadas em relação a existência de crimes ambientais no município. Para isso foram utilizadas ferramentas do sensoriamento remoto (SR) e sistema de informação geográfica (SIG) para o cruzamento e sobreposição dos dados utilizados nas análises. A base cartográfica do limite municipal foi obtido do Instituto Brasileiro de Geografia e Estatística (IBGE), os focos de queimadas foram coletados na plataforma Bdqueimdas/Inpe, dados de desmatamento foram colhidas do Programa de Monitoramento da Amazônia (PRODES) e os embargos adquiridos do Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis (IBAMA). Em seguida ambos os dados foram espacializados no software Qgis 3.10, e sequência foi aplicado o algoritmo de Kernel. Dessa forma, foi possível fazer as devidas correlações espaciais das informações supracitadas. Observou-se, no intervalo estudado que o maior registro de incidências de queimadas foi o ano de 2019, concentrando 52,02% do total de focos acumulados de 2014 a 2019. Esses focos se concentraram principalmente nas regiões norte, nordeste e oeste do município, ao longo da BR-230, apresentando maior ocorrência entre os meses de setembro e novembro. Tais registros desse processo, estão rotineiramente relacionados de atividades antrópicas como desmatamentos, queima de vegetação que tem resultado em diversas propriedades embargadas, comprovadas com a metodologia utilizada, para este estudo. Por fim, o uso dessa metodologia apresentou-se, como uma ferramenta promissora, que através do uso de geotecnologias foi possível espacializar e reunir em um só produto cartográfico os focos de calor, os desmatamentos e as áreas embargadas, desta forma confirmando que a maioria dos focos de calor registrados no município estar ligado ao processo de desflorestamento e outras práticas irregulares resultando em diversos crimes ambientais, sendo comprovados através desses mesmos espaços que sofreu o desmate e ateamento do fogo, que tem resultado em propriedades embargadas.
El uso TIC´S en el proceso de enseñanza-aprendizaje del alemán como lengua extranjera en la universidad
Authors: Ahumada Ebratt Dayson David 
Published: May 2021

El presente artículo de reflexión tuvo como objetivo describir el uso de las TICS en la enseñanza del alemán como lengua extranjera en la educación superior. Para ello el estudio se enfocó en una revisión documental cuyos autores hicieron énfasis en el uso de las TICS para fortalecer las competencias comunicativas de los estudiantes, como Cariaga (2018), Chao (2014), Hernández (2017), entre otros. En este orden, la investigación, inscrita en el paradigma cualitativo, tuvo entre sus resultados que las TIC´S permiten tanto al docente como al estudiante, tener acceso a diversos materiales y niveles de interacción, ya sea docente- estudiante o estudiantes – estudiantes, lo que sin duda fortalece el proceso de enseñanza – aprendizaje. Asimismo, durante la revisión de la literatura se pudo constatar que el estudio de las herramientas TIC´S a nivel universitario amerita una investigación mucho más detallada y rigurosa, puesto que es un tema con una gran cantidad de matices.
* Este artículo se desprende de la tesis de maestría titulada “El uso TIC´S en el proceso de enseñanza-aprendizaje del alemán como lengua extranjera en la universidad del Norte de Barranquilla, Colombia”. Presentada en la UNEATLANTICO-UNINI-PR.
Elasmobrânquios demersais da Reserva Biológica Marinha do Arvoredo, SC (Brasil)
Authors: Kotas Jorge Eduardo , Nürnberg dos Santos Agatha Caroline , Scalco Allan 
Published: May 2021

A Reserva Biológica Marinha do Arvoredo, localizada no litoral centro-norte catarinense, é uma área de proteção integral, com o objetivo de preservar a diversidade biológica e seus processos ecológicos naturais. Pela sua proximidade da costa, vem sendo constantemente ameaçada pelas atividades antrópicas, como é o caso da pesca e da ocupação desordenada da zona litorânea. Informações sobre a diversidade ecológica de elasmobrânquios dentro da REBIO Arvoredo e seu entorno, foram obtidas através dos cruzeiros efetuados pelo NPq. “Soloncy Moura” entre os anos de 2009 e 2011. Foram encontradas espécies que habitavam exclusivamente a plataforma continental e que habitavam tanto a plataforma como o talude superior. Estimativas das densidades (nº de ind./ha) na REBIO foram obtidas através do método da área varrida, tanto para as redes de arrasto-de-fundo para camarões como a de peixes. As espécies mais abundantes Rioraja agassizi e Zapteryx brevirostris, apresentaram as maiores densidades no inverno. Modelos de Análise de Variância indicaram diferenças significativas nos comprimentos totais (CT) médios das fêmeas destas duas espécies (p<0,05) nas diferentes áreas analisadas. Para R. agassizi este foi menor na Zona de Normatização da Pesca e Turismo (ZN) do que na Zona de Amortecimento (ZA) e litoral de Santa Catarina (LSC). No caso de Z. brevirostris este foi maior na ZA do que no LSC. Os resultados obtidos sobre as composições de tamanhos e estágios reprodutivos confirmaram a hipótese de que a REBIO Arvoredo fornece abrigo para 19 espécies de elasmobrânquios, inclusive espécies ameaçadas de extinção, como é o caso de Pseudobatos horkelii, Squatina guggenheim, espécies com dados deficientes (Narcine brasiliensis e Atlantoraja platana) e principalmente representantes da ordem Rajiformes que utilizam a área para o parto, a cópula, bem como berçário e alimentação.
Pelatihan Autodesk Revit Bagi Komunitas Samarinda Young Architect Forum
Authors: Bhanu Rizfa Hakim  , Musthafa A.P Hatta , Hidayati Zakiah , Thamrin Nur Husniah 
Published: May 2021

Perkembangan dunia arsitektur pada revolusi industri 4.0 sangatlah cepat, sehingga dibutuhkan kemampuan adaptasi cepat agar dalam proses rancang bangun. Proses menggambar atau mendesain bangunan pun turut terpengaruh, yang dahulu dilakukan berhari-hari, pada era revolusi industri 4.0 dapat dikerjakan dalam waktu jam. BIM merupakan seperangkat teknologi yang dijalankan secara digital berisi tentang seluruh informasi yang diperlukan dalam merancang bangunan. Software BIM salah satunya adalah Revit Building Arsitektural. Tujuan pengabdian ini adalah memberikan pelatihan dasar penggunaan software Revit kepada Komunitas Arsitek Samarinda yang tergabung dalam Samarinda Young Architect Forum. Samarinda Young Architect Forum diisi oleh Mahasiswa dan Pengusaha Jasa Arsitektur hingga drafter gambar. Berdasarkan hasil evaluasi kegiatan, peserta dapat membuat rumah sederhana dalam waktu singkat dari perencanaan denah, perencanaan kusen, dan perencanaan atap yang dikemas dalam konsep gambar kerja.
Kata Kunci : Autodesk Revit, BIM, Revolusi Industri 4.0, Samarinda Young Architect Forum
Protective Effects of Folic Acid and Vitamin C Against Iron Overload at the in vitro Blood-Brain Barrier
Authors: ATASEVER ARSLAN Belkis , SATICI İdil , ARSLAN Enes Furkan , YANIK Ayşegül , KUŞOĞLU GÜLTEKİN Seda 
Published: May 2021

Brain iron accumulation increases with age and this is more common in patients with neurodegenerative diseases such as Parkinson's disease. Also iron overload in addition to zinc accompanies with plaques containing β-amyloid (AP) of Alzheimer’s Disease. The blood-brain barrier (BBB) is a dynamic interface between the blood and the brain that plays an important role in maintaining central nervous system (CNS) homeostasis.
In our study, protective effects of vitamin C and folic acid against iron overload in the in vitro blood-brain barrier model were investigated. Four different groups were created for the experimental procedure: 1) Control, 2) FeSO4, 3) FeSO4 + Vit C, 4) FeSO4 + Folic acid for toxicity experiments. After iron overload, permeability differences of Vitamin C and folic acid in vitro BBB model were assayed using Bovine Serum Albumin (BSA) Bradford protein assay. Both substances were found to have a protective effect against iron sulphate-induced damage. Also, vitamin C and folic acid significantly decrease the permeability after increasing caused by iron sulfate in BBB model. Considering the toxic effects of high concentrations of vitamin C, systemic effects of folic acid should also be investigated by in vivo studies to compare with vitamin C in ageing.