bluuebunny/crossref_metadata_2025_split huggingface dataset:
The land carrying capacity and environmental risk assessment of livestock and poultry breeding considering crop planting
Authors: Yang Nian , Chen Lei , Wang Wenzhuo , Shen Zhenyao 
Published: April 2021

Abstract
At present, the contradiction between survival and ecology necessitates the integration of crop planting, chemical fertilizer application and livestock and poultry breeding. Reasonably integrated crop-livestock systems (ICLSs) have become an important part of regional ecological and agricultural development. In this study, the relationship between manure nutrient demands for crops and manure nutrient supply from livestock is considered based on the balance of ICLSs in Jiangxi Province, China. The land carrying capacity index and potential of livestock breeding under uncoordinated systems are further discussed. The study also addresses water environmental risk due to surplus nutrients by integrating a traditional land carrying capacity framework and hydrological model. The results show that phosphorus absorption in land areas is the main limiting factor for the development of the livestock and poultry industries. In addition, manure nutrient demand exceeded supply in most districts, while the unbalanced regions with nutrient pollution are located in the upper and middle reaches of the Ganjiang basin. In addition, expanding the crop demand for manure or increasing the manure collection rate will help reduce environmental harm; however, attention should be paid to the risk of excessive manure returns. Additional livestock manure can be transferred to regions with developed crop planting systems. This study supports more harmonious and common ICLSs construction.
Genotypic differences of Cd concentration and nutrition traits of 23 main celery cultivars of China in a Cd contaminated greenhouse
Authors: Zhou Qiyao , Wang Qiong , Huang Lukuan , Ma Luyao , Wu Yingjie , Jiang Yugen , Feng Ying 
Published: April 2021

Abstract
Due to the increasing concerns of heavy metal contamination in greenhouse field, safety production of vegetables especially leafy vegetables was largely limited. In this study, the cadmium (Cd) concentration and major nutrition qualities of 23 main celery cultivars of China were compared in a greenhouse experiment. Great genotypic differences in biomass, cadmium accumulation and nutrition traits were observed. The biomass of cultivars HQ, JZ, JH and SQ were significantly higher than those of the others. And Cd concentration in edible part ranged from 0.53 to 2.56 mg·kg− 1 DW, of which SQ exhibited the lowest Cd concentration. In addition, SQ has the lowest Cd transport factor (TF) and bio-concentration factor (BCF), followed by another genotype LF. Simultaneously, they have relatively higher chlorophyll content and vitamin C concentration, lower cellulose content. Therefore, the two genotypes SQ and LF were selected as promising candidates to grow on a mid Cd-contaminated greenhouse field to achieve safety production. Further correlation analysis showed that Cd concentration in edible part is positively correlated with cellulose content, but negatively correlated with vitamin C concentration. The results of celery variety screening provide a safe production strategy of moderately polluted greenhouse vegetable fields.
Role of cholinergic anti-inflammatory pathway in protecting sepsis-induced acute lung injury through regulation of the dendritic cells
Authors: Li Ruiting , Hu Xuemei , Chen Huibin , Yuan Yin , Guo Huiling , Gao Xuehui , Huang Haiyan , Zou Xiaojing , Qi Hong , Liu Hong 
Published: April 2021

Abstract
Background

The cholinergic anti-inflammatory pathway (CAP) connects the immune response system and the nervous system via the vagus nerve. The key regulatory receptor is the α7-subtype of the nicotinic acetylcholine receptor (α7nAChR), which is localized on the surface of the cells of immune system. CAP has been proved to be effective in suppressing the inflammation responses in acute lung injury (ALI). Dendritic cells (DCs), the important antigen-presenting cells (APCs), also express the α7nAChR. They not only play an important role in immune response priming but also in participating in the pathological process of ALI. Past studies have indicated that reducing the quantity of mature conventional DCs (cDCs) and inhibiting the maturation of pulmonary DCs may prove effective for the treatment of ALI. However, the effects of CAP on maturation, function and quantity of DCs and cDCs in ALI remain unclear.
Objective

It was hypothesized that the activation of CAP may inhibit the inflammatory response of ALI by regulating maturation, phenotype, and quantity of DCs and cDCs. This can be considered as an important intervention strategy for treating ALI.
Methods

GTS-21 (GTS-21 dihydrochloride), an α7nAchR agonist was administered in sepsis-induced ALI mice model and LPS-primed bone marrow-derived dendritic cells (BMDCs). The effects of GTS-21 were observed with respect to maturation, phenotype, and quantity of DCs, cDCs, and cDCs2 (type 2 cDCs), and the release of DC-related pro-inflammatory cytokines (such as IL-6, TNF-α, IL-18 IL-1β, IL-12p40, and HMGB1) in vivo and in vitro conditions.
Results

The results of the present study revealed that, GTS-21 treatment regulated the maturation of DCs and the production of DC-related pro-inflammatory cytokines in vitro and in sepsis-induced ALI mice model, it reduced the quantity of CD11c+MHCII+ cDCs and CD11c+CD11b+ cDCs2 in vivo experiment.
Conclusions

The activation of CAP contributes to the reduction in the inflammatory response in ALI by regulating maturation, phenotype, and quantity of DCs, cDCs, and cDCs2.
Rice husk and saw dust reinforced hybridized blends of bio-benzoxazine/epoxy based composites: Thermal, Mechanical, and Acoustic Absorption Properties
Authors: Arumugam Hariharan , Krishnasamy Balaji , Dilip Anto , MI Abdul Aleem , Muthukaruppan Alagar 
Published: April 2021

Abstract
The prime objective of the present work is to develop bio-wastes (rice husk and saw dust) reinforced composites with varying weight percentages composition of hybridized blend made from bio-based cardanol-melamine, cardanol-aniline benzoxazine and epoxy resin (bio-benzoxazine : epoxy resin 0:100 and 50:50 wt%)for acoustic proof applications. The breakthrough achieved in the present work is the cardanol benzoxazine is made in the form of hybrid matrix with epoxy resin, which cures significantly at lower temperature of 1050C in the absence of any curatives and also cures at room temperature in the presence of isophorone diamine curative,whereas the cardanol-melamine and cardanol-aniline based benzoxazines cure at very high temperature of 221˚C and 275 ˚C respectively. The low temperature cure behaviour achieved in the present work facilitates the amenable fabrication of bio-composites using both low heat resistant bio-based reinforcements and high temperature cure bio-benzoxazines for making cost competitive green building materials. Cardanol-melamine (C-m) and cardanol-aniline (C-a) based benzoxazines were synthesised using cardanol separately with melamine (m) and aniline (a) in the presence of paraformaldehyde under suitable experimental conditions. The benzoxazine (C-m and C-a) obtained was blended with varying weight percentages of bisphenol-A epoxy (DGEBA) resin separately followed by reinforcing with rice husk and saw dust and then cured at room temperature with stoichiometric quantity of isophorone diamine to obtain corresponding hybrid bio-composites. Mechanical properties (tensile strength, modulus, percentage elongation and hardness), thermal conductivity, thermal resistance, and sound absorption coefficient were studied as per standard methods. Results obtained from different studies infer that hybrid blended cardanol benzoxazine composite panels reinforced with rice husk and saw dust possess appreciable thermal, mechanical and acoustic properties. Data obtained from acoustic studies, it was observed that the highest value of sound absorption coefficient of 6400 Hz was noticed for composite specimens developed using both rice husk and saw dust reinforced with hybridized blend of bio-benzoxazine (50wt%) and epoxy resin (50wt%) and these hybrid composite panels can be used as sound absorption material in the ceiling and wall construction applications.
A case of occult colon cancer with sepsis as the primary manifestation guided by bone marrow puncture
Authors: wang hua jun , ZHOU chenjie , Wang jianhua 
Published: April 2021

Abstract
Background: Bone marrow metastasis is common in liver cancer and lung cancer, but there are few reports on bone marrow metastasis of colon cancer. So far, there are no research reports from mainland China; especially reports of bone marrow metastasis combined with septic shock as the main manifestation are even rarer. Case presentation: A 71-year-old elderly woman with sepsis as the first symptom, mainly manifested as high fever, low blood pressure, high inflammation indicators, etc. CT examination revealed mild inflammation of the lungs and no obvious abnormalities in the abdomen. Blood culture culture suggested Escherichia coli and Aeromonas hydrophila/caviae. After anti-infective treatment, the patient's sepsis symptoms improved significantly, but after repeated platelet transfusion, he still could not correct hypothrombosis. Finally, a large number of malignant cells were found through a bone marrow puncture smear, and further PET-CT examination confirmed that the ascending colon malignant tumor was accompanied by multiple metastases such as the liver and bones. The patient was eventually unable to tolerate surgery due to bone marrow failure and liver failure and died 3 weeks after admission.Conclusions: We hope that this case report can raise people’s awareness of the insidiousness of colon cancer and the possibility of metastasis to the bone marrow, especially for patients with progressive thrombocytopenia that is difficult to correct. Thrombocytopenia needs to be treated differently from sepsis.
A model and predictions for COVID-19 considering population behavior and vaccination
Authors: Usherwood Thomas , LaJoie Zachary , Srivast Vikas 
Published: April 2021

Abstract
The effect of vaccination coupled with the behavioral response of the population is not well understood. Our model incorporates two important dynamically varying population behaviors: level of caution and sense of safety. Level of caution increases with infectious cases, while an increasing sense of safety with increased vaccination lowers precautions. Our model accurately reproduces the complete time history of COVID-19 infections for various regions of the United States. We propose a parameter d_I as a direct measure of a population’s caution against an infectious disease that can be obtained from the infectious cases. The model provides quantitative measures of highest disease transmission rate, effective transmission rate, and cautionary behavior. We predict future COVID-19 trends in the United States accounting for vaccine rollout and behavior. Although a high rate of vaccination is critical to quickly ending the pandemic, a return towards pre-pandemic social behavior due to increased sense of safety during vaccine deployment can cause an alarming surge in infections. Our results predict that at the current rate of vaccination, the new infection cases for COVID-19 in the United States will approach zero by August 2021. This model can be used for other regions and for future epidemics and pandemics.
Linking qualitative scenarios with quantitative energy models. Knowledge integration in different methodological designs.
Authors: Prehofer Sigrid , Kosow Hannah , Naegler Tobias , Pregger Thomas , Vögele Stefan , Weimer-Jehle Wolfgang 
Published: April 2021

Abstract
BackgroundLinking qualitative scenarios with quantitative models is a common approach to integrate assumptions on possible future societal contexts into modeling. But reflection on how and to what degree knowledge is effectively integrated during this endeavor does not generally take place. In this paper, we reflect on the performance of a specific hybrid scenario approach (qualitative Cross-Impact Balance analysis linked with quantitative energy models) concerning knowledge integration through eleven different process steps. In order to guide the scenario community in applying this approach, we reflect on general methodological features as well as different design options. We conceptualize different forms of interdisciplinary knowledge integration (compiling, combining and synthesizing) and analyze how and to what degree knowledge about society and uncertainty are integrated into scenario process and products. In addition, we discuss trade-offs regarding design choices and forms of knowledge integration.ResultsOn the basis of three case studies we identify two general designs of linking which build on each other (basic and extended design) and which differ in essence regarding the balance of power between the CIB and the energy modeling. Ex-post assessment of the form of interdisciplinary knowledge integration in each step revealed that specific method properties of CIB as well as the interaction with additional quantitative as well as specific qualitative methods foster distinct forms of knowledge integration. The specific roles assigned to CIB in the hybrid scenario process can also influence the form of knowledge integration. ConclusionsIn this study, we use a joint process scheme linking qualitative context scenarios with energy modeling. By applying our conceptualization of different forms of knowledge integration we analyze the designs´ respective potential for and respective effects on knowledge integration. Consequently, our findings can give guidance to those who are designing their own hybrid scenario processes. As this is an explorative study, many roads for further empirical research are indicated. Finally, we note that at some points in the process a more precise differentiation of knowledge integration forms would have been useful and propose to further differentiate and detail the three forms of interdisciplinary knowledge integration in future research.
Efficacy of Active and Passive Evidence-Based Practice Training for Postgraduate Medical Residents: A Non-Randomized Controlled Trial
Authors: Goodarzi Hassan , Teymourzadeh Ehsan , Rahimi Siyavash , Nasiri Taha 
Published: April 2021

Abstract
ObjectiveThis study examined the effects of two evidence-based practice (EBP) educational programs for postgraduate medical residents on their attitude, behavior, knowledge, outcome, and competencies in EBP. ResultsThirty-nine and thirty postgraduate medical residents were recruited for the active intervention and passive intervention groups. 66.6% of the active group participants and 66.6% of participants in the passive group were males (p>0.05). Participants in the active group were significantly younger than the passive group (p<0.0001). The active and passive intervention groups were not significantly different from each other at the baseline in the EBP-KABQ questionnaire (p>0.05). However, most questions were significantly different from the pre-intervention measurement and the passive intervention group after the educational intervention. Before the educational intervention, both groups had similar ACE tool scores (4.14 ± 1.72 in the active group vs. 4.79 ± 0.94 in the passive group, p>0.05). However, educational intervention in both groups led to a significant difference between groups (8.86 ± 2.62 vs. 7.31 ± 2.92, p= 0.029, in the active and passive group, respectively). Paired t-test analysis revealed that our intervention has lead to a significant increase in ACE tool scores in both groups (p<0.000, in both groups).
Sonogames: Sounds of the Right Kind; Introducing Gamification Into Radiology Training
Authors: Ali Maria Fatima , Nadeem Naila , Khalid Farah , Anwar Naveed Muhammad , Nabie Ghulam , Docherty Charles 
Published: April 2021

Abstract
ObjectiveRadiology as compared to other fields of medicine has lagged, in incorporating modern training modalities such as gamification and simulation into its teaching curriculum. This study aims to evaluate effectiveness of simulation-based teaching (SBT) in collaboration with gamification. Albert Bandura's conception of self-efficacy was used to provide qualitative assessment of participants' learning process through training event. Modified competitive game-based teaching methodology was utilized. Workshop was divided into two sessions, first being three interactive didactic lectures followed by three competitive rounds. All participants were required to fill a self-administered pre- and post-self-efficacy questionnaire along with an activity evaluation form. ResultsSelf-efficacy scores for simulation-based stations for knowledge assessment and hands-on stations showed a significant p-value <0.05. Whereas significant association with respect to gender and knowledge assessment was found in communication skill (0.054), Professionalism (0.004), and general knowledge (0.018). Significant association was found between gender and all the hands-on skills. In conclusion, study reported an overall increase in knowledge of post-test scores compared to pre-test scores. Use of gamification in combination with SBT shows a positive role in clinical training. However, this field needs further consideration to better the process of integrating simulation in clinical training of participants.
Gastrointestinal perforation following dabrafenib and trametinib administration in non-small cell lung carcinoma with BRAF V600E mutation: a case report and literature review
Authors: Shimada Yuri , Sato Yuki , Tachikawa Ryo , Hara Shigeo , Tomii Keisuke 
Published: April 2021

Abstract
Gastrointestinal perforation related to mitogen-activated protein kinase kinase (MEK) inhibitors has been reported previously; however, there has been no case report of such a condition in patients with non-small cell lung cancer (NSCLC). Herein, we report a case of small intestinal perforation secondary to dabrafenib and trametinib administration, but not related to tumor regression. A 62-year-old man with non-small cell lung cancer harboring BRAF V600E mutation was treated with dabrafenib and trametinib. Four months after the initiation of treatment, a small intestinal perforation was diagnosed. Dabrafenib and trametinib rechallenge was performed after gastrointestinal perforation. The patient responded well to therapy and did not experience recurrence of gastrointestinal perforation. To the best of our knowledge, this is the first report of gastrointestinal perforation in a patient with NSCLC treated with a MEK inhibitor. The mechanism and risk factors of trametinib-induced perforation are currently unknown. Physicians should be aware of such severe gastrointestinal side effects of trametinib.
Continuous Low-Intensity Ultrasound Preserves Mitochondrial Potential, Inhibits NFκB Activation and Rescues Chondrogenesis of Mesenchymal Stromal Cells
Authors: Bhogoju Sarayu , Khan Shahid , Wang Denzhi , Subramanian Anuradha 
Published: April 2021

Abstract
Objective: Dysregulation of the anabolic processes in a proinflammatory joint environment coupled with impeded chondrogenic differentiation of mesenchymal stromal cells (MSCs) led to inferior cartilage repair outcomes. The preponderance of proinflammatory cytokines activated nuclear factor kappa B (NFκB) and impeded the chondrogenesis of MSCs. Thus, strategies that minimize the deleterious effects of activated NFκB while promoting MSC chondrogenesis are of interest. The present study establishes the ability of continuous low-intensity ultrasound (cLIUS) to rescue MSC chondrogenesis impacted by a proinflammatory environment. Methods: Human bone marrow-derived MSCs were seeded in alginate:collagen hydrogels and cultured for 21-days in an ultrasound-assisted bioreactor 14 kPa (5.0 MHz, 2.5 Vpp; 4-applications/day) for 21 days in the presence of IL1β and evaluated by qRT-PCR (n=10), immunofluorescence (n=15), western blotting (WB) (n=6), and immunohistochemistry (n=3). The differential expression of markers associated with NFκB pathway under cLIUS were evaluated upon a single exposure of cLIUS and assayed by qRT-PCR (n=3), immunofluorescence (n=30-60), WB (n=6) and tetramethylrhodamine methyl ester assay (n=50) was used to assess the mitochondrial potential under IL1β and cLIUS treatment.Results: Chondroinductive potential of cLIUS was preserved as noted by the increased expression of SOX9 and deposition of collagen II. cLIUS extended its chondroprotective effects by stabilizing the NFκB complex in the cytoplasm via engaging the IκBα feedback mechanism, thus preventing its nuclear translocation. cLIUS acted as a mitochondrial protective agent by restoring the mitochondrial potential and the mitochondrial mRNA expression in a proinflammatory environment. Conclusion: Our results demonstrated the potential of cLIUS for cartilage repair and regeneration under proinflammatory conditions.
Effect of Textile-Substrate Pore Size on Electromagnetic Interference Shielding Performance of Conductive Nanocomposite Coated Fabrics
Authors: Hou Yijie , Guo Min , Li Xiangpeng , Duan Minghan , Jia Yongtang , Yan Jianhua , Wang Xianfeng , MA Ying 
Published: April 2021

Abstract
Textile-substrate electromagnetic interference (EMI) shielding materials show great promise for next-generation electronic communication technology challenges. However, new strategies based on structure optimization are desired for improving EMI shielding performance. Here, we demonstrate the controlling effect of fabric structure on the shielding effectiveness of the EMI fabrics. Plain fabrics with different fabric densities were weaved and used as the substrate to be layer-by-layer assembled by graphite oxide (GO) and polypyrrole (PPy). The conductive GO/PPy nanocomposite coating endows commercial cotton fabrics with an EMI shielding ability. In comparison, the EMI shielding effectiveness of the GO/PPy fabrics is depended on the fabric density, that is, the pore size. The EMI shielding effectiveness of the 100 × 100 picks/ 10cm coated fabric was 19.2 dB in 3.9−6.0 GHz frequency range, which is increased by about 71% through the control of the textile-substrate pore size. Interestingly, the EMI shielding effectiveness always peaks at the fabric density of 100 × 100 picks/ 10cm, different from the electrical conductivity. Moreover, the sueding treatment can further improve the EMI shielding effectiveness of the GO/PPy coated fabrics. It is because that the creation of plush increases the multi-reflection of electromagnetic waves in the fabric. This work presents the significance of fabric structure to EMI shielding performance, offering new opportunities for the development of high efficiency EMI shielding fabrics.