bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review and Correlational Meta-Analysis of Factors Associated With Resilience of Normally Aging, Community-Living Older Adults
Authors: Górska Sylwia , Singh Roy Anusua , Whitehall Lucy , Irvine Fitzpatrick Linda , Duffy Nichola , Forsyth Kirsty 
Published: August 2021

Abstract

Background and Objectives
Global policy emphasizes the need to promote healthy aging through supporting inclusivity, safety, and functional independence. Research indicates that efforts to enhance resilience can contribute to meeting these objectives. We employed a meta-analytical approach to examine evidence on resilience in community-living older adults.

Research Design and Methods
We searched electronic databases until January 13, 2020 for observational studies investigating factors associated with resilience in this population. Articles had to provide quantitative data based on standardized assessment and include samples where mean participants’ age and lower 95% confidence interval were more than 55 years. We included 49 studies reported in 43 articles and completed 38 independent meta-analyses, 27 for personal and 11 for contextual factors associated with resilience.

Results
A range of personal and contextual factors were significantly associated with resilience, with effects sizes predominantly small to moderate (0.1 &lt; r &lt; 0.49). Factors reflecting psychological and physical well-being and access to/quality of social support were associated with higher resilience. Factors indicative of poorer psychological well-being and social challenges were associated with lower resilience. Longitudinal evidence was limited. The level of between-study heterogeneity was substantial to considerable. Where relevant analysis was possible, the identified publication bias was also considerable.

Discussion and Implications
The quality of the available evidence, as well as issues related to measurement of resilience, indicates the need for further work relative to its conceptualization and assessment. The presented findings have important clinical implications, particularly within the context of the coronavirus disease 2019 impact on resilience in older adults.
Trademark Opposition Proceedings in Switzerland: An Empirical Study of Legal Reasoning
Authors: Thouvenin Florent , Gerber Daniel , Altwicker Tilmann 
Published: August 2021

Abstract
This study is the first empirical analysis of legal reasoning in trademark opposition proceedings in Switzerland. We examine a novel dataset on trademark opposition proceedings brought before the Swiss Federal Institute of Intellectual Property (IPI). In these proceedings, the likelihood of confusion between two (or more) trademarks is assessed based on the similarity of the trademark signs and the similarity of the goods and services, taking into account a series of additional aspects such as the distinctive character of the opposing trademark and the level of attention of the average consumer when buying the goods and services for which the earlier trademark is registered. Our dataset contains information on 2,453 cases relating to proceedings between June 2002 and August 2018. In particular, we examine which substantive factors drive the outcome of these decisions. Some of our findings call into question the established legal doctrine. For example, our data suggest that the importance of the beginning of words for establishing similarity between word marks is overrated by legal doctrine. Furthermore, our data show no clear influence of the level of attention on the assessment of the likelihood of confusion. Instead, we found striking differences between the success rates of different types of trademarks. In fact, the data reveal a sliding scale with word marks being the most successful trademarks followed by figurative trademarks that contain a word element, and purely figurative trademarks. Based on our empirical findings, we make suggestions on how to improve the legal reasoning when assessing the likelihood of confusion.
Global Experience With Rotavirus Vaccines
Authors: Burke Rachel M , Tate Jacqueline E , Parashar Umesh D 
Published: August 2021

Abstract
Rotavirus is a major cause of severe pediatric diarrhea worldwide. In 2006, 2 live, oral rotavirus vaccines, Rotarix and RotaTeq, were licensed for use in infants and were rapidly adopted in many high- and middle-income settings where efficacy had been demonstrated in clinical trials. Following completion of successful trials in low-income settings, the World Health Organization (WHO) recommended rotavirus vaccination for all infants globally in 2009. In 2018, 2 new rotavirus vaccines, Rotasiil and Rotavac, were prequalified by WHO, expanding global availability. As of March 2021, rotavirus vaccines have been introduced nationally in 106 countries. Since, Rotavirus vaccines have demonstrated effectiveness against severe disease and mortality, even among age groups in eligible for vaccination. Cross-genotypic protection has been demonstrated, and the favorable benefit-risk profile of these vaccines continues to be confirmed. Ongoing research seeks to better understand reasons for the geographic disparities in effectiveness observed, in order to optimize vaccine strategies worldwide.
Engineering acetyl-CoA supply andERG9repression to enhance mevalonate production inSaccharomyces cerevisiae
Authors: Wegner Scott A , Chen Jhong-Min , Ip Samantha S , Zhang Yanfei , Dugar Deepak , Avalos José L 
Published: August 2021

AbstractMevalonate is a key precursor in isoprenoid biosynthesis and a promising commodity chemical. Although mevalonate is a native metabolite in Saccharomyces cerevisiae, its production is challenged by the relatively low flux toward acetyl-CoA in this yeast. In this study we explore different approaches to increase acetyl-CoA supply in S. cerevisiae to boost mevalonate production. Stable integration of a feedback-insensitive acetyl-CoA synthetase (Se-acsL641P) from Salmonella enterica and the mevalonate pathway from Enterococcus faecalis results in the production of 1,390 ± 10 mg/l of mevalonate from glucose. While bifid shunt enzymes failed to improve titers in high-producing strains, inhibition of squalene synthase (ERG9) results in a significant enhancement. Finally, increasing coenzyme A (CoA) biosynthesis by overexpression of pantothenate kinase (CAB1) and pantothenate supplementation further increased production to 3,830 ± 120 mg/l. Using strains that combine these strategies in lab-scale bioreactors results in the production of 13.3 ± 0.5 g/l, which is ∼360-fold higher than previously reported mevalonate titers in yeast. This study demonstrates the feasibility of engineering S. cerevisiae for high-level mevalonate production.
Hapax remains: Regularity of low-frequency words in authorial texts
Authors: Faltýnek Dan , Matlach Vladimír 
Published: August 2021

Abstract
This article highlights the usual overlook in the literature of regular occurrences of low-frequency words (hapax legomena) in specific authors’ texts. This overlook arises from a linguistic assumption of non-systematic and context-dependent low-frequency word occurrences in extensive texts, and from the tendency of SVM methods to mark low-frequency words as irrelevant compared to the more frequent lexicon (e.g. Boukhaled, M. A. and Ganascia, J.-G. (2015). Using function words for authorship attribution: bag-of-words vs. sequential rules. In The 11th International Workshop on Natural Language Processing and Cognitive Science, October 2014, Venice, Italy. de Gruyter, Natural Language Processing and Cognitive Science Proceedings 2014, pp. 115–122.). Many approaches to authorship attribution are based on the n most frequent ‘function words’, which (1) are grammatically essential, frequent, and therefore included in each text; (2) are not affected by the topic of the text; and (3) reflect the unintentional linguistic activity of the author (Binongo, J. N. G. (2003). Who wrote the 15th book of Oz? An application of multivariate analysis to authorship attribution. Chance, 16(2): 9–17). Hapax legomena meet these conditions as well, except frequency (Baayen, H., van Halteren, H., and Tweedie, F. (1996). Outside the cave of shadows: using syntactic annotation to enhance authorship attribution. Literary and Linguistic Computing, 11(3): 121–32). We test the hypothesis that hapax legomena may work for purposes of authorship attribution based on selecting only hapaxes from whole texts (or randomly selected tokens of hapaxes) while using a specific pre-processed input (eigendecomposition of a cosine distance matrix) to the SVM classifier. This method evaluated the attribution of texts from fourteen Czech authors (yielding ninety-one pairs in total) and Evert, S., Proisl, T., Jannidis, F. et al. (2017). Understanding and explaining Delta measures for authorship attribution. Digital Scholarship in the Humanities, 32(2): 4–16 data set, and proved itself a suitable tool for identifying authors of previously unknown texts. Our method identifies a sparse network of regular occurrences of low-frequency words in different authors’ texts.
Geometry effects on dust attenuation curves with different grain sources at high redshift
Authors: Lin Yen-Hsing , Hirashita Hiroyuki , Camps Peter , Baes Maarten 
Published: August 2021

ABSTRACT
Dust has been detected in high-redshift (z &gt; 5) galaxies but its origin is still being debated. Dust production in high-redshift galaxies could be dominated by stellar production or by accretion (dust growth) in the interstellar medium. Previous studies have shown that these two dust sources predict different grain-size distributions, which lead to significantly different extinction curves. In this paper, by performing radiative transfer calculations, we investigate how the difference in the extinction curves affects the dust attenuation properties of galaxies. To examine the major effects of the dust–stars distribution geometry, we adopt two representative cases in spherical symmetry: the well-mixed geometry (stars and dust are homogeneously mixed) and the two-layer geometry (young stars are more concentrated in the centre). In both cases, we confirm that the attenuation curve can be drastically steepened by scattering and by different optical depths between young and old stellar populations, and can be flattened by the existence of unobscured stellar populations. We can reproduce similar attenuation curves even with very different extinction curves. Thus, we conclude that it is difficult to distinguish dust sources only with attenuation curves. However, if we include information on dust emission and plot the relation between infrared excess (IRX) and the ultraviolet spectral slope (β), then different dust sources predict different positions in the IRX–β diagram. A larger β is preferred under a similar IRX if dust growth is the dominant dust source.
Balmer-series spectral lines for hydrogen atoms in parallel magnetic and electric fields of white dwarfs
Authors: Zhao L B , Liu F L 
Published: August 2021

ABSTRACT
We extended the two-dimensional B-spline approach recently developed to investigate the influence of a strong electric field on atomic structures and spectra for hydrogen atoms in magnetic fields of white dwarfs. Spectral lines for hydrogen in parallel magnetic and electric fields have been calculated. Wavelengths and oscillator strengths are presented for 14 Balmer α transitions as a function of magnetic and electric fields. The magnetic and electric field strengths involved span a scope, respectively, from around 23.5 to 2350 MG, and from 0 to 108 V/m. Our calculations show that the shift of Balmer-series spectral lines induced by a strong electric field reduces as the magnetic field strength increases. The obtained energy levels, wavelengths, and oscillator strengths are compared to available results in the literature, and excellent agreement was discovered. The spectral data reported in this paper can be applied to interpret the shifts of spectral lines of hydrogen in magnetic white dwarfs due to the presence of electric fields, and to predict additional spectral lines dipole-forbidden in a pure magnetic field.
Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells
Authors: Babarinde Isaac A , Ma Gang , Li Yuhao , Deng Boping , Luo Zhiwei , Liu Hao , Abdul Mazid Md , Ward Carl , Chen Minchun , Fu Xiuling , Shi Liyang , Duttlinger Martha , He Jiangping , Sun Li , Li Wenjuan , Zhuang Qiang , Tong Guoqing , Frampton Jon , Cazier Jean-Baptiste , Chen Jiekai , Jauch Ralf , Esteban Miguel A , Hutchins Andrew P 
Published: August 2021

Abstract
Transposable elements (TEs) occupy nearly 40% of mammalian genomes and, whilst most are fragmentary and no longer capable of transposition, they can nevertheless contribute to cell function. TEs within genes transcribed by RNA polymerase II can be copied as parts of primary transcripts; however, their full contribution to mature transcript sequences remains unresolved. Here, using long and short read (LR and SR) RNA sequencing data, we show that 26% of coding and 65% of noncoding transcripts in human pluripotent stem cells (hPSCs) contain TE-derived sequences. Different TE families are incorporated into RNAs in unique patterns, with consequences to transcript structure and function. The presence of TE sequences within a transcript is correlated with TE-type specific changes in its subcellular distribution, alterations in steady-state levels and half-life, and differential association with RNA Binding Proteins (RBPs). We identify hPSC-specific incorporation of endogenous retroviruses (ERVs) and LINE:L1 into protein-coding mRNAs, which generate TE sequence-derived peptides. Finally, single cell RNA-seq reveals that hPSCs express ERV-containing transcripts, whilst differentiating subpopulations lack ERVs and express SINE and LINE-containing transcripts. Overall, our comprehensive analysis demonstrates that the incorporation of TE sequences into the RNAs of hPSCs is more widespread and has a greater impact than previously appreciated.
Surgical versus conservative management of tongue lacerations in the acute care setting: A systematic review of the literature
Authors: Gonsalves Clarelle L , Zhu Jie Wei , Kim Grace Y , Leveille Cameron F , Kam April J 
Published: August 2021

Abstract

Objective
The objective of this study was to determine whether suturing or conservative management of tongue lacerations results in differences in wound healing and functional outcome. The secondary aim was to identify whether antibiotics are required in the treatment of tongue lacerations.

Methods
Studies published between December 1954 and August 2020 were extracted from MEDLINE via PubMed, Embase via OVID, CINAHL via EBSCO, Web of Science, and the Cochrane Library and evaluated for inclusion based on predetermined inclusion and exclusion criteria by two independent reviewers in accordance with PRISMA guidelines.

Results
The search yielded a total of 16,111 articles, 124 of which were evaluated by full-text review, resulting in 11 articles included in this systematic review representing 142 unique cases of tongue lacerations. At least 26 lacerations (18.3%) included penetration of the muscle layer of the tongue, and 24 (16.9%) were classified as full-thickness lacerations. Thirty-five of the 142 tongue lacerations (24.6%) were sutured. The remaining lacerations underwent some form of conservative management. The majority of studies reported excellent healing of tongue lacerations regardless of the management method, with minimal scarring and excellent return to normal functional status. No cases of infection were reported.

Conclusions
Current literature is inconsistent with regards to indications and guidelines for primary repair of tongue lacerations. The majority of tongue lacerations reported in the literature heal with excellent outcomes regardless of management method. Physician judgement along with patient and parental preference based on potential risks of the procedure should be used when deciding whether a tongue laceration requires primary repair. Tongue lacerations in otherwise healthy individuals are at very low risk of infection.
Are Positive Psychology Interventions Efficacious in Chronic Pain Treatment? A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Braunwalder Céline , Müller Rachel , Glisic Marija , Fekete Christine 
Published: August 2021

Abstract

Objective
Although positive psychology interventions (PPIs) are increasingly popular in chronic pain treatment their efficacy is still unclear. The objective is to summarize evidence on the effect of PPIs on pain, physical functioning, and emotional functioning in adults with chronic pain.

Methods
Four electronic databases and additional references were searched for randomized controlled trials (RCTs) published between 1990 and 2020. Findings from included studies were qualitatively and quantitatively synthesized, and study quality was assessed for risk of bias. A random effects meta-analysis model was applied for outcomes with more than four findings.

Results
Of 16 included RCTs, almost half delivered PPIs as self-help online interventions, and half conducted guided face-to-face interventions which lasted mostly eight weeks. Results from meta-analysis showed beneficial effects of PPIs compared to the control group on pain intensity and emotional functioning (i.e., less depressive symptoms, pain catastrophizing, negative affect; more positive affect) post-intervention. At 3-month follow-up, beneficial effects were maintained for depressive symptoms and positive and negative affect, but not for pain catastrophizing. However, the evidence on the long-term efficacy of PPIs and the efficacy of PPIs on physical functioning remains limited.

Conclusions
This review supports the notion that PPIs are beneficial to chronic pain treatment, although further, high quality research is needed to support this conclusion.
A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
Authors: Yang Jianmin , Huang Yufeng , Dai Jiajia , Shi Xianai , Zheng Yunquan 
Published: August 2021

Abstract
Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with silver nanoparticles (AgNPs) was developed for severe burn wound healing. AgNPs were in situ synthesized on the fibers of chitosan nonwoven fabric (CSNWF) as the interlayer of wound dressing for sustained release of silver ion. The firmly anchored AgNPs could prevent its entry into the body, thereby eliminating the toxicity of nanomaterials. The outer layer was a polyurethane membrane, which has a nanoporous structure that could maintain free transmission of water vapor. Chitosan/collagen sponge was selected as the inner layer because of its excellent biocompatibility and biodegradability. The presence of AgNPs in the CSNWF was fully characterized, and the high antibacterial activity of CSNWF/AgNPs was confirmed by against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The superior wound healing effect on deep dermal burns of presented composite wound dressing was demonstrated in a porcine model. Our finding suggested that the prepared AgNPs doped sandwich structure composite wound dressing has great potential application in severe wound care.
The effect of neural cell integrated into 3D co-axial bioprinted BMMSC structures during osteogenesis
Authors: Zhang Yi , Chen Haiyan , Long Xiaoyan , Xu Tao 
Published: August 2021

Abstract
A three-dimensional (3D) bioprinting is a new strategy for fabricating 3D cell-laden constructs that mimic the structural and functional characteristics of various tissues and provides a similar architecture and microenvironment of the native tissue. However, there are few reported studies on the neural function properties of bioengineered bone autografts. Thus, this study was aimed at investigating the effects of neural cell integration into 3D bioprinted bone constructs. The bioprinted hydrogel constructs could maintain long-term cell survival, support cell growth for human bone marrow-derived mesenchymal stem cells (BMMSCs), reduce cell surface biomarkers of stemness, and enhance orthopedic differentiation with higher expression of osteogenesis-related genes, including osteopontin (OPN) and bone morphogenetic protein-2. More importantly, the bioprinted constructs with neural cell integration indicated higher OPN gene and secretory alkaline phosphatase levels. These results suggested that the innervation in bioprinted bone constructs can accelerate the differentiation and maturation of bone development and provide patients with an option for accelerated bone function restoration.
Miscarriage, False Conceptions, and Other Lumps: Women’s Pregnancy Loss in Seventeenth- and Eighteenth-Century England
Authors: Donaghy Paige 
Published: August 2021

Summary
Histories of early modern medicine and generation have tended to overlook the place that miscarriage, infertility, false conception and uterine diseases had in medical knowledge and women’s lives. By exploring English medical literature, casebooks, and letters, the study argues that a wide range of physical events, including miscarriage and false conception or mola, were experienced by women as a pregnancy, and then as the ‘loss of pregnancy’, or the loss of a potential infant. Early modern women often felt distress, grief and confusion at such losses, and medical practitioners formulated specific responses or treatments to these women’s experiences of losses. Considering miscarriage, false conception and uterine masses through the concept of ‘pregnancy loss’ challenges current narratives about generation. It shows that at this time a variety of gestational experiences, such as non-foetal gravidities and miscarriage formed part of ‘generation’, alongside the conception and birth of living infants.