bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interplay between non‐alcoholic fatty liver disease and cardiovascular risk in an asymptomatic general population
Authors: Pennisi Grazia , Di Marco Vito , Buscemi Carola , Mazzola Giovanni , Randazzo Cristiana , Spatola Federica , Craxì Antonio , Buscemi Silvio , Petta Salvatore 
Published: April 2021

AbstractBackground and AimsNon‐alcoholic fatty liver (NAFLD) is a major cause of liver disease worldwide leading also to a higher risk of cardiovascular events. We aimed to evaluate the impact of fatty liver and fibrosis on cardiovascular risk in a general population.MethodsFive hundred and forty‐two subjects included in the community‐based ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study were recruited. Steatosis (controlled attenuation parameter > 288 dB/m) and severe fibrosis (low risk, liver stiffness measurement [LSM] < 7.9 KPa with M probe and < 5.7 KPa with XL probe; intermediate risk, LSM 7.9–9.5 KPa with M probe and 5.7–9.2 KPa with XL probe; high risk, LSM ≥ 9.6 KPa with M probe and ≥ 9.3 KPa with XL probe) were assessed with FibroScan. Cardiovascular risk was evaluated by the atherosclerotic cardiovascular disease (ASCVD) risk estimator and defined low if < 5%, borderline if 5–7.4%, intermediate if 7.5–19.9% and high if ≥ 20%. Intima‐media thickness (IMT) was measured with ultrasound.ResultsPrevalence of steatosis and of severe fibrosis in this cohort was 31.7% and 4.8%, respectively. ASCVD score was evaluated in patients with and without steatosis and according to the risk of severe fibrosis. By ordinal regression analysis, both steatosis (odds ratio [OR] 1.62, 95% confidence interval [CI] 1.13–2.33, P = 0.009) and severity of fibrosis (OR 1.67, 95% CI 1.18–2.36, P = 0.003) were independent risk factors for a higher ASCVD risk after adjusting for obesity. Subjects with NAFLD, when compared with those without, did not differ for IMT (0.75 vs 0.72 mm; P = 0.11) and IMT ≥ 1 mm (15.6% vs 12.1%; P = 0.24). Higher prevalence of IMT ≥ 1 mm was found in patients at high or intermediate risk of severe fibrosis (24% and 28.6%, respectively) compared with those at low risk (12.1%) (P = 0.03); this association was maintained after adjusting for confounders (OR 2.70, 95% CI 1.01–2.86, P = 0.04).ConclusionIn the setting of a general adult population, the presence of NAFLD and severe fibrosis are associated with to a higher cardiovascular risk profile, pointing towards the need for specific preventive measures.
Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis
Authors: Lv Jian , Liu Jingyan , Ming Yuhang , Shi Yiting , Song Chunpeng , Gong Zhizhong , Yang Shuhua , Ding Yanglin 
Published: April 2021

AbstractProtein phosphorylation and dephosphorylation have been reported to play important roles in plant cold responses. In addition, phospho‐regulatory feedback is a conserved mechanism for biological processes and stress responses in animals and plants. However, it is less well known that a regulatory feedback loop is formed by the protein kinase and the protein phosphatase in plant responses to cold stress. Here, we report that OPEN STOMATA 1 (OST1) and PROTEIN PHOSPHATASE 2C G GROUP 1 (PP2CG1) reciprocally regulate the activity during the cold stress response. The interaction of PP2CG1 and OST1 is inhibited by cold stress, which results in the release of OST1 at the cytoplasm and nucleus from suppression by PP2CG1. Interestingly, cold‐activated OST1 phosphorylates PP2CG1 to suppress its phosphatase activity, thereby amplifying cold signaling in plants. Mutations of PP2CG1 and its homolog PP2CG2 enhance freezing tolerance, whereas overexpression of PP2CG1 decreases freezing tolerance. Moreover, PP2CG1 negatively regulates protein levels of C‐REPEAT BINDING FACTORs (CBFs) under cold stress. Our results uncover a phosphor/dephosphor‐regulatory feedback loop mediated by PP2CG1 phosphatase and OST1 protein kinase in plant cold responses.
Exploring newly qualified nurses’ experiences of support and perceptions of peer support online: A qualitative study
Authors: Jenkins Catharine , Oyebode Jan , Bicknell Sarah , Webster Natalie , Bentham Peter , Smythe Analisa 
Published: April 2021

AbstractAims and ObjectivesTo explore newly qualified nurses’ support needs and their perceptions of online peer support.BackgroundThe experience of being a newly qualified nurse is stressful and isolating. Support from colleagues and peers can enhance perceptions of competence and confidence in newly qualified nurses, improve well‐being and aid retention. However, despite initiatives such as preceptorship, support needs may remain unmet in busy clinical environments. Online support has potential to offer a partial solution to professional isolation, but there is a lack of research into how technology can support nurses’ emotional and social well‐being.DesignA qualitative exploratory study was designed, employing semi‐structured focus groups, analysed using thematic analysis. The study is reported in accordance with the COnsolidated criteria for REporting Qualitative research checklist.MethodsEight focus groups, supplemented by one individual interview, were conducted with newly qualified nurses between June 2018–January 2019.FindingsTwo main themes arose. The first was Drowning, a lot of the time with two sub‐themes: (i) Feelings and emotions about being a Newly Qualified Nurse: ‘Absolutely terrified’ and (ii) Support within the role: ‘Somebody you can count on’. The second was Potential advantages and disadvantages of online modality: ‘Somebody is going to get in that phone!’ which included three sub‐themes (i) Potential advantages, (ii) Potential disadvantages and (iii) Preferences and recommendations.ConclusionsThis study demonstrates that if barriers can be overcome, then online support has potential to contribute to newly qualified nurses’ well‐being. Further research is needed to explore technical and ethical issues around online support and evaluate its effectiveness for newly qualified nurses.Relevance to clinical practiceOnline support has the potential to add to existing strategies to support nurses during stressful times. This may be particularly relevant when many staff are working under increased pressure due to the COVID‐19 pandemic.
Outcome of in vitro fertilization cycles with automatic time‐lapse instrumentation combined with the early embryo viability assessment score
Authors: Kokunai Kana , Yamashita Yoshiki , Inoue Taketo , Taguchi Sayumi , Tsujimoto Yoshiko , Hirao Kayoko , Yamamoto Syuji , Nakamura Natsuho , Terai Yoshito , Ohmichi Masahide 
Published: April 2021

AbstractAimTo evaluate whether embryo selection using the early embryo viability assessment (EEVA) score increases the ongoing pregnancy rate of in vitro fertilization and intracytoplasmic sperm injection patients.MethodsOne hundred eighty‐one patients whose serum anti mullerian hormone (AMH) level was greater than 0.5 ng/μL were enrolled in the study. All patients received oocyte retrieval repeatedly from June 2017 to January 2019.Transferred embryos were selected using the EEVA score and Veeck's criteria. We investigated the blastocyst rate according to the EEVA score and Veeck's criteria and also evaluated the clinical outcome following embryo transfer of the blastocysts.ResultsBlastocyst development rate (48.7%) and high‐quality blastocyst (42.4%) of Veeck 1 was statistically higher than others.The blastocyst rate (71.4%) and high‐quality blastocyst rate (60.0%) for EEVA 1 was the highest, and a correlation between the EEVA score and the blastocyst rate was also identified in cases younger than 40 years. Blastocyst rate of EEVA 1 + 2 (69.8% 208/298) was statistically higher than that of Veeck 1 + 2 (40.1% 317/791) (p < 0.05) and high‐quality blastocyst rate of EEVA 1 + 2 (50.0% 104/208) was also higher than that of Veeck 1 + 2 (36.6% 117/320) (p < 0.05).However, there was a significant correlation between EEVA and the pregnancy rate and pregnancy rate of EEVA 1 + 2 showed no statistical difference compared with Veeck 1 + 2.ConclusionsAlthough it remains to be answered whether a computer can substitute Veeck's classification, the EEVA score could be a viable alternative to predict the blastocyst rate and to select those high‐potential embryos that improve the pregnancy rate.
The influence of mode of delivery, anthropometric indices, and infant's sex on the maternal and cord blood orexin‐A levels: A cohort study
Authors: Razavinia Fatemeh , Tehranian Najmeh , Sadatmahalleh Shahideh Jahanian , Kazemnejad Anoshirvan , Khajetash Shaghayegh , Daryasari Seyedeh Razieh Fazeli , Pahlavan Fattaneh , Jahanfar Shayesteh 
Published: April 2021

AbstractBackgroundOrexin as an adipokin hormone plays an important role in appetite regulation, energy metabolism, obesity, diabetes, and cardiovascular disease. The main source of orexin secretion in nonpregnant and pregnant women is adipose tissue and placenta, respectively. This research was conducted to evaluate the association between orexin‐A level and the mode of delivery, anthropometric indices, and sex of the infant.MethodsThis prospective cohort study was conducted on 69 normal pregnant women. The samples of umbilical cord blood were obtained at the time of delivery, and maternal blood was taken within 24 h of delivery. Serum orexin‐A levels were measured by using enzyme‐linked immunosorbent assay. Statistical analyses were performed using SPSS and p < 0.05 was considered as significant.ResultsWe found a significant difference between postpartum maternal and umbilical cord orexin‐A level both with the mode of delivery (p < 0.001). Also, a significant positive correlation was seen between maternal and umbilical cord serum orexin‐A levels (r = −0.61, p < 0.001). There was no relationship between serum orexin‐A levels with anthropometric indices and the sex of the neonate (p > 0.05).ConclusionBoth maternal and umbilical cord serum orexin‐A levels were associated with the mode of delivery. Maternal and cord blood orexin‐A levels in normal vaginal delivery are higher than cesarean section.
A case of cervical clear cell carcinoma with serous component
Authors: Ebisawa Keiko , Sugiyama Takahiro , Itami Makiko , Maru Yoshiaki , Hippo Yoshitaka , Tanaka Naotake 
Published: April 2021

AbstractCervical clear cell carcinoma (CCCC) is rare. This report describes the case of CCCC with a serous component. A 22‐year‐old woman presented with vaginal bleeding. A cervical tumor was discovered: pelvic magnetic resonance imaging revealed a tumor measuring 46 mm. Radical hysterectomy was performed based on the diagnosis of stage IB2 cervical cancer. After histological examination of the specimen revealed a coexisting invasive clear cell carcinoma (95%) and serous carcinoma (5%), five cycles of nedaplatin and irinotecan therapy were administered as postoperative adjuvant chemotherapy. Local recurrence in the vaginal vault was observed at 7 months after surgery. Radiation therapy and chemotherapy were administered. The patient is alive without evidence of recurrence at 26 months after surgery.
Failure Load of Monolithic Lithium Disilicate Implant‐Supported Single Crowns Bonded to Ti‐base Abutments versus to Customized Ceramic Abutments after Fatigue
Authors: Spitznagel F. A. , Bonfante E. A. , Vollmer F. , Gierthmuehlen P. C. 
Published: April 2021

AbstractPurposeThis laboratory study analyzed the influence of retention mode (screw‐ vs cement retained) and fatigue application on the failure load of monolithic lithium‐disilicate (LDS) implant‐supported single crowns (ISSC).Material and MethodsA total of 72 samples of monolithic LDS (*Ivoclar Vivadent) ISSC were divided into three groups (n = 24) according to their type of retention mode: Group Ti‐CAD: Titanium base (SICvantage CAD/CAM Abutment red (SIC invent AG), screw‐retained milled monolithic LDS (IPS e.max CAD*); Group Ti‐P: Titanium base (SICvantage CAD/CAM Abutment red), screw‐retained pressed monolithic LDS (IPS e.max Press*) and Group Ti‐Cust: Titanium base with cemented press LDS (IPS e.max Press*) crown on a LDS (IPS e.max Press*) custom abutment. A mandibular first molar implant‐supported single crown model was investigated (Titanium implant: SICvantage‐max, SIC invent AG, diameter: 4.2 mm, length: 11.5 mm). Half of each group (n = 12) w​ere exposed to fatigue with cyclic mechanical loading (F = 198 N, 1.2 million cycles) and simultaneous thermocycling (5‐55°C). Single load to failure testing was performed, before (Subgroups Ti‐CAD, Ti‐P, and Ti‐Cust) and after (Subgroups Ti‐CAD‐F, Ti‐P‐F, and Ti‐Cust‐F) fatigue. Weibull distribution was used to determine the characteristic strength and Weibull modulus differences between groups. Probability of survival at 900N load was calculated.ResultsNo samples failed during fatigue. Characteristic strength values were as follow: Ti‐CAD: 3259.5N, Ti‐CAD‐F: 2926N, Ti‐P: 2763N, Ti‐P‐F: 2841N, Ti‐Cust: 2789N, Ti‐Cust‐F: 2194N. Whereas no difference was observed between pressed or milled monolithic crowns cemented to Ti‐base, regardless of loading condition, fatigue decreased the characteristic strength of crowns cemented to custom abutments. Probability of survival at 900 N was not significantly different between groups.ConclusionsScrew‐retained pressed or milled monolithic LDS ISSC, cemented directly to Ti‐base abutments or LDS crowns cemented to custom ceramic abutments resist physiological chewing forces after simulated 5‐year aging in the artificial mouth and presented equally high probability of survival. However, a significant decrease in load to failure was observed in LDS crowns cemented to custom ceramic abutments after fatigue. Prospective clinical trials are needed to confirm the results of this laboratory investigation.
Polyploidy in Cupressaceae: Discovery of a new naturally occurring tetraploid, Xanthocyparis vietnamensis
Authors: Farhat Perla , Siljak‐Yakovlev Sonja , Hidalgo Oriane , Rushforth Keith , Bartel Jim A. , Valentin Nicolas , Leitch Ilia J. , Adams Robert P. 
Published: April 2021

AbstractWhile polyploidy (whole‐genome multiplication) is generally considered rare in extant gymnosperms (with the exception of Ephedra, Ephedraceae), the occurrence of sporadic polyploid individuals belonging to various genera in the conifer family Cupressaceae has been reported in the literature. In addition, recent studies have revealed that polyploidy is not uncommon in the genus Juniperus (Cupressaceae), with tetraploid and hexaploid individuals reported in individuals collected from wild populations. Given these findings, we undertook a comprehensive screening of ploidy levels in 32 species belonging to the four genera that are phylogenetically closest to Juniperus (i.e., Callitropsis, Hesperocyparis, Xanthocyparis, and Cupressus), referred to as the CaHXCu complex. In addition, we also determined the ploidy level of two accessions in the poorly studied tetraploid, Fitzroya cupressoides. Using flow cytometry together with published chromosome counts to assign ploidy levels, we show that all species of the CaHXCu complex are diploid except Xanthocyparis vietnamensis, which is tetraploid, with a genome size of 44.60 pg/2 C. This study opens up new opportunities for studying the impact and consequences of polyploidy on the evolution and adaptation of species in Cupressaceae.
Association between daytime napping and stroke: A dose–response meta‐analysis
Authors: Jin Xiaolin , Chen Hanze , Li Yuru , Xu Wenying , Chen Xinxin , Tian Li , Teng Weiyu 
Published: April 2021

AbstractDaytime napping is common in many regions around the world and has been an important part of people's daily life. Daytime napping has attracted increasing attention in recent years. Thus, we conducted a meta‐analysis to evaluate the relationship between daytime napping and stroke, and help reduce the risk of stroke by improving living habits. The Embase, PubMed, Web of Science and PsycINFO databases were searched for cohort studies published before October 2020 and eight eligible studies with 524,408 participants and 5,875 stroke cases were included in the final analysis. The pooled relative risk (RR) of stroke was 1.47 (95% confidence interval [CI]: 1.24–1.74; p < .001) with significant heterogeneity (I2 = 58%, p for heterogeneity = 0.02). However, the heterogeneity decreased when the study in which adjusting for sleep duration and stratifying the results based on sleep duration was not performed was excluded (RR: 1.38; 95% CI: 1.19–1.60, I2 = 44%, p for heterogeneity = 0.10). In dose–response analysis, the linear trend indicated that for every 10‐min increase in daytime napping, the risk of stroke increased by 3%. Further well‐designed large studies are needed to explore the effects of daytime napping on stroke and the underlying biological mechanisms.
An agent‐based model to optimize transboundary management for the walleye pollock (Gadus chalcogrammus) fishery in the Gulf of Alaska
Authors: Williams Benjamin C. , Criddle Keith R. , Kruse Gordon H. 
Published: April 2021

AbstractBecause fish stocks often straddle state, national, and international boundaries, there is a need to coordinate fishery management across jurisdictions. This is particularly important when the abundance or spatial distribution of the stock varies through time. This is best achieved when management objectives and strategies align, and there is coordinated decision‐making and catch accounting among jurisdictions such that each fish stock is managed over its full geographic range. However, legal constraints or differing management objectives may not permit such coordinated decision making and policy development. This study introduces a framework for effectively simulating fleet dynamics, fishery quota allocation, and the implications of alternative management strategies while allowing for determination of economically optimal management approaches at the community level. As a case study, an agent‐based model (ABM) was developed to examine the interplay between transboundary management scenarios on the economic viability of a nascent Alaska state‐waters trawl fishery for walleye pollock (Gadus chalcogrammus) in the Gulf of Alaska, given a longstanding federally managed fishery. Under conditions characteristic of the recent past, the management strategy that produced the best overall improvements, relative to status quo, involved a scenario that allows for community‐based cooperatives in federal‐waters and an open access strategy in state‐waters. This case study allows us to demonstrate more generally how using an ABM allows for quantifying the impacts of and informing managers on anticipated, and novel, results of alternative management strategies for complex socioecological systems before implementation.Recommendations for Resource Managers

Agent‐based modeling provides a method to realistically simulate fleet behavior within a fishery.
The approach enables a quantitative analysis of the effects of alternative management scenarios under consideration by policymakers.
“Best practices” for fishery management should include simulation analysis of management alternatives before selection of the preferred alternative for real‐world implementation.
The classical Confucian conception of Heaven's Mandate
Authors: Jia Jinhua 
Published: April 2021

AbstractThe belief in heaven's mandate (tianming 天命) in earlier documents referred to divine‐ethical sanctions of political rulers. It later developed multiple implications such as an individual's destiny or fate and became one of the most fundamental concepts in Chinese intellectual and cultural history. In modern times, this concept has received long‐lasting attention in the field of Chinese philosophy, and almost all major scholars have more or less been involved in discussions and debates, especially on the topic of the classical Confucian conception of heaven's mandate. Their discussions on this topic have largely focused on two major controversies: (i) whether early Confucians view heaven's mandate as prescriptive ethical command or descriptive amoral fate, and (ii) whether their attitude toward heaven's mandate is voluntarist or fatalistic. While this scholarship has been fruitful and insightful, it has continued for almost a century with certain variants. Therefore, it is time to address this topic with new approaches and hermeneutic horizons. In this essay, I propose a new approach and horizon to viewing the classical Confucian conception of heaven's mandate as their reflections on individual existence and self‐realization under the constraints of mandate or destiny. I examine the texts associated with Confucius and Mencius such as the Analects and the Mencius, as well as some recently unearthed texts, to suggest that early Confucians accommodate individual initiative and self‐determination of life choices through their conceptualization of heaven's mandate. To them, the vocabulary of heaven's mandate empowers individuals, especially through situating their places in society and the cosmos. By knowing and standing firmly on one's mandate or destiny, the individual not only realizes the value of their existence but also goes beyond the ultimate destiny of death. This fresh reading of heaven's mandate is grounded in the context of the development of Confucian ideas in the early period and presents an optimistic vision of Confucian humanism.
Measuring the impact of suicide attempt posttraumatic stress
Authors: O’Connor Stephen S. , McClay Michael M. , Powers Jeffery , Rotterman Erik , Comtois Katherine Anne , Ellen Wilson Jo , Nicolson Stephen E. 
Published: April 2021

AbstractObjectiveTo examine the associations between posttraumatic stress symptoms (PTS) following a medically serious suicide attempt with suicidal ideation, related interpersonal constructs, and outpatient mental health service utilization.MethodsThe study utilized an existing data set from a clinical trial consisting of 66 patients recruited at a level 1 trauma center following medical admission for a suicide attempt. Measures of suicide attempt‐related PTS (SA‐PTS), suicidal ideation, perceived burdensomeness, thwarted belongingness, and outpatient medical and mental health utilization were completed at 1 and 3 months. A series of mixed‐effects regression models were used to analyze the data.ResultsGreater SA‐PTS at 1 month was associated with significantly greater suicidal ideation, thwarted belongingness, and perceived burdensomeness across 1 and 3 months.ConclusionsAddressing PTS following a medically serious suicide attempt may aid in addressing suicide‐specific constructs and improve the recovery trajectory following hospitalization.