bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Type 2 Diabetes Onset Age With Cardiovascular Disease and Mortality: The Kailuan Study
Authors: Zhao Maoxiang , Song Lulu , Sun Lan , Wang Miao , Wang Chi , Yao Siyu , Li Yao , Yun Cuijuan , Zhang Sijin , Sun Yizhen , Hou Ziwei , Wu Shouling , Xue Hao 
Published: April 2021

OBJECTIVE
We aimed to explore the associations between type 2 diabetes onset age and cardiovascular disease (CVD) and all-cause mortality in the Chinese population.

RESEARCH DESIGN AND METHODS
This study included 101,080 participants free of prevalent diabetes and CVD at baseline from the Kailuan Study. All participants were monitored biennially until 31 December 2017. During follow-up, 11,384 participants were diagnosed as having type 2 diabetes. For each case subject, one control subject was randomly selected, matched for age (± 1 years) and sex. The final analysis comprised 10,777 case-control pairs. Weighted Cox regression models were used to evaluate the average hazard ratios (AHRs) and 95% CIs of incident CVD and all-cause mortality among patients with new-onset type 2 diabetes versus control subjects across age-groups.

Results
During a median follow-up of 5.57 years, 1,794 incident events (907 CVD events, of which there were 725 strokes and 887 deaths) occurred. After adjustment for potential confounders, participants with type 2 diabetes diagnosed at age &lt;45 years had the highest relative risks of CVD and all-cause mortality relative to the matched control subjects, with AHRs of 3.21 (95% CI 1.18–8.72) for CVD, 2.99 (95% CI 1.01–9.17) for stroke, and 4.79 (95% CI 1.95–11.76) for all-cause mortality. The risks gradually attenuated with each decade increase in type 2 diabetes onset age.

CONCLUSIONS
The relative risks of CVD and all-cause mortality differed across type 2 diabetes onset age-groups, and the associations were more evident in younger-onset type 2 diabetes.
Italian Cardiological Guidelines (COCIS) for Competitive Sport Eligibility in athletes with heart disease: update 2020
Authors: Delise Pietro , Mos Lucio , Sciarra Luigi , Basso Cristina , Biffi Alessandro , Cecchi Franco , Colivicchi Furio , Corrado Domenico , D’Andrea Antonello , Di Cesare Ernesto , Di Lenarda Andrea , Gervasi Salvatore , Giada Franco , Guiducci Vincenzo , Inama Giuseppe , Leoni Loira , Palamà Zefferino , Patrizi Giampiero , Pelliccia Antonio , Penco Maria , Robles Antonio Gianluca , Romano Silvio , Romeo Francesco , Sarto Patrizio , Sarubbi Berardo , Sinagra Gianfranco , Zeppilli Paolo 
Published: April 2021

Since 1989, SIC Sport and a FMSI, in partnership with leading Italian Cardiological Scientific Associations (ANCE, ANMCO and SIC) have produced Cardiological Guidelines for Completive Sports Eligibility for athletes with heart disease (COCIS -- 1989, 1995, 2003, 2009 and 2017).
The English version of the Italian Cardiological Guidelines for Competitive Sports Eligibility for athletes with heart disease was published in 2013 in this Journal. This publication is an update with respect to the document previously published in English in 2013. It includes the principal innovations that have emerged over recent years, and is divided into five main chapters: arrhythmias, ion channel disorders, congenital heart diseases, acquired valve diseases, cardiomyopathies, myocarditis and pericarditis and ischemic heart disease. Wherever no new data have been introduced with respect to the 2013 publication, please refer to the previous version.
This document is intended to complement recent European and American guidelines but an important difference should be noted. The European and American guidelines indicate good practice for people engaging in physical activity at various levels, not only at the competitive level. In contrast, the COCIS guidelines refer specifically to competitive athletes in various sports including those with high cardiovascular stress. This explains why Italian guidelines are more restrictive than European and USA ones. COCIS guidelines address ‘sports doctors’ who, in Italy, must certify fitness to participate in competitive sports. In Italy, this certificate is essential for participating in any competition.
Citric Acid Production of Yeasts: An Overview
Authors: Börekçi Bilge Sayın , Kaban Güzin , Kaya Mükerrem 
Published: April 2021

Abstract

Background
Citric acid, an intermediate product of the Krebs cycle, has a wide usage area in the food industry since it has some functions such as acidulant, flavouring agent, preservative and antioxidant. Although molds are the most commonly used microorganisms in the citric acid production, it is known that there are significant advantages of using yeasts.

Purpose and scope
The microbial citric acid production mechanism needs to be well understood to make production more efficient. In this study, the yeasts used in the production, fermentation types and the factors affecting production were reviewed with studies.

Methodology
Although production of citric acid can be produced by chemical synthesis, the fermentation is preferred because of its low cost and ease of use. More than 90% of citric acid produced in the world is obtained by fermentation.

Results

Yarrowia lipolytica, Candida zeylanoides and Candida oleophila are evaluated for citric acid production with substrates such as molasses, glucose, sucrose and glycerol. On the other hand, there is great interest in developing processes with new substrates and/ or microorganisms.

Conclusion
Although the microbial strain is an important factor, the factors such as carbon, phosphorus and nitrogen sources, aeration, the presence of trace elements and pH are also parameters affecting the production.
Penguatan Intervensi Perilaku terhadap Pencegahan HIV pada Kelompok Berisiko: Sistematik Review
Authors: Suarnianti Suarnianti , Haskas Yusran 
Published: April 2021

Intervensi perilaku sangat penting dilakukan dalam pencegahan HIV sebagai intervensi dalam upaya meningkatkan status kesehatan. Tujuan: Mengetahui bentuk intervensi perilaku untuk mengukur outcome dari pencegahan terjadinya HIV terutama pada kelompok berisiko. Metode: Electronic database dari jurnal yang telah dipublikasikan melalui ProQuest, PubMed., dan ScienceDirect. Hasil: Review dari delapan jurnal yang telah dipilih menyatakan bahwa intervensi perilaku memberi pengaruh terhadap peningkatan pengetahuan tentang HIV/AIDS, konseling bagi kelompok dengan rIsiko tinggi seperti pada Lelaki Seks dengan Lelaki (LSL) dan juga pelaksanaan tes HIV atau yang dikenal dengan Voluntary Counseling and Testing (VST). Instrumen penelitian yang digunakan untuk mengukur behavioral intervention pada penelitian kuantitaif yakni kuesioner, instrumen berbasis komputer dan internet seperti sosial media, sedangkan pada penelitian kualitatif menggali informasi dengann indepth interview dan Focus Group Discussion (FGD). Hasil penelitian menunjukkan bahwa penguatan intervensi perilaku dalam pencegahan HIV memberi manfaat dalam peningkatan pengetahuan, persepsi dan perilaku pencegahan HIV positif, serta penurunan stigma bagi ODHA. Simpulan: Penguatan intervensi perilaku dapat mencegah terjadinya HIV pada kelompok berisiko sehingga dapat meningkatkan derajat kesehatan.Kata kunci: intervensi perilaku, pencegahan HIV, LSL
Rancang Bangun Sistem Monitoring Denyut Jantung SpO2 dan Suhu Tubuh Penderita COVID-19 Berbasis IoT
Authors: Tachiyat Sayyidati Zuhroh , Imanda Arsa Rizky , Tholib Mukhamad Azis 
Published: April 2021

<p class="JIPIAbstractBody">Telah berhasil diciptakan alat monitoring denyut jantung, saturasi oksigen (SpO<sub>2</sub>) dalam darah, dan suhu tubuh penderita COVID-19 berbasis IoT. Alat ini berupa gelang yang mana terdiri dari beberapa alat penting, yaitu NodeMCU ESP8266, TCA9548A, lcd oled 128 x 64 pixel, sensor AD8232, sensor MAX30100, dan sensorMPU6050. Alat ini ditujukan untuk penanganan penderita COVID-19 di Indonesia khususnya pasien rawat inap yang berada di rumah sakit darurat ataupun rumah sakit rujukan COVID-19. Metode analisis yang digunakan dalam penelitian ini adalah metode perbandingan, yaitu dengan membandingkan hasil ukur alat yang dibuat dengan alat ukur yang telah ada, seperti oximeter dan thermometer klinis. Hasil ukur denyut jantung menunjukan error yang besar, yaitu sebesar 4,12%, sedangkan hasil ukur saturasi oksigen dan suhu tubuh memiliki error relatif kecil, yaitu sebesar 1,27% dan 0,35%. Hasil pengukuran dapat dilihat pada website Thingspeak.com dalam bentuk grafik. Pengiriman data dengan kecepatan internet 1,27 Mbps alat berhasil mengirimkan 16 dari 220 data dengan jeda 16-60 detik. Peletakan sensor denyut jantung yang tidak tepat memberikan error yang cukup besar.</p>
QPowered Compound2DeNovoDrugPropMax –A Novel Programmatic Tool Incorporating Deep Learning and In Silico Methods for Automated In Silico Bio- Activity Discovery for any Compound of Interest
Authors: Geoffrey A S Ben , Madaj Rafal , Sanker Akhil , Valluri Pavan Preetham , Geoffrey Ben 
Published: April 2021

Network data is composed of nodes and edges. Successful application of machine learning/deeplearning algorithms on network data to make node classification and link prediction have been shownin the area of social networks through which highly customized suggestions are offered to socialnetwork users. Similarly one can attempt the use of machine learning/deep learning algorithms onbiological network data to generate predictions of scientific usefulness. In the presented work,compound-drug target interaction network data set from bindingDB has been used to train deeplearning neural network and a multi class classification has been implemented to classify PubChemcompound queried by the user into class labels of PBD IDs. This way target interaction prediction forPubChem compounds is carried out using deep learning. The user is required to input the PubChemCompound ID (CID) of the compound the user wishes to gain information about its predictedbiological activity and the tool outputs the RCSB PDB IDs of the predicted drug target interaction forthe input CID. Further the tool also optimizes the compound of interest of the user toward druglikeness properties through a deep learning based structure optimization with a deep learning baseddrug likeness optimization protocol. The tool also incorporates a feature to perform automated InSilico modelling for the compounds and the predicted drug targets to uncover their protein-ligandinteraction profiles. The program is hosted, supported and maintained at the following GitHubrepositoryhttps://github.com/bengeof/Compound2DeNovoDrugPropMaxAnticipating the rise in the use of quantum computing and quantum machine learning in drug discovery we usethe Penny-lane interface to quantum hardware to turn classical Keras layers used in our machine/deeplearning models into a quantum layer and introduce quantum layers into classical models to produce aquantum-classical machine/deep learning hybrid model of our tool and the code corresponding to thesame is provided belowhttps://github.com/bengeof/QPoweredCompound2DeNovoDrugPropMax
Self-monitoring Techniques: Perbedaan Peningkatan Achievement Motivation Siswa SMA Berdasarkan Jenis Kelamin (Gender)
Authors: Utomo Prio , Zubaidah Zubaidah 
Published: April 2021

Penelitian ini dilatar belakangi oleh masalah pencapaian prestasi akademik siswa rendah, data awal pra-penelitian diperoleh temuan bahwa masalah pencapaian prestasi akademik siswa rendah disebabkan oleh achievement motivation siswa rendah. Tujuan penelitian untuk mengetahui perbedaan peningkatan achievement motivation siswa berdasarkan jenis kelamin (gender) setelah diberi teknik self-monitoring. Rancangan penelitian menggunakan experimental research dengan grup prestest and posttest design. Subjek penelitian siswa kelas XI SMA 03 Kota Bengkulu berjumlah 10 siswa terdiri dari 5 siswa laki-laki dan 5 siswa perempuan. Instrumen penelitian menggunakan skala achievement motivation dan pedoman perlakuan. Analisis data menggunakan analisis statistik nonparametrik dengan Wilcoxom Signed Rank Test. Pengujian hipotesis menunjukkan H0 ditolak dan H1 diterima, hal ini berarti tidak terdapat perbedaan peningkatan achievement motivation siswa berdasarkan jenis kelamin (gender) setelah diberi teknik self-monitoring. Nilai rata-rata peningkatan siswa perempuan sebelum (pretest) sebesar 1,922 dan sesudah (posttest) sebesar 3,184. Sedangkan nilai rata-rata peningkatan siswa laki-laki sebelum (pretest) sebesar 1,931, dan sesudah (posttest) sebesar 3,086. Simpulan hasil penelitian menunjukkan tidak terdapat perbedaan peningkatan achievement motivation siswa laki-laki dan perempuan setelah diberi teknik self-monitoring dan peran jenis kelamin (gender) tidak memberikan pengaruh terhadap peningkatan achievement motivation siswa.
Experimental Determination of Mantle Solidi and Melt Compositions for Two Likely Rocky Exoplanet Compositions
Authors: Brugman Karalee , Phillips Mitchell , Till Christy 
Published: April 2021

For rocky exoplanets, knowledge of their geologic characteristics such as composition and mineralogy, surface recycling mechanisms, and volcanic behavior are key to determining their suitability to host life. Thus, determining exoplanet habitability requires an understanding of surface chemistry, and understanding the composition of exoplanet surfaces necessitates applying methods from the field of igneous petrology.Piston-cylinder partial melting experiments were conducted on two hypothetical rocky exoplanet bulk silicate compositions. HEX1, a composition with molar Mg/Si = 1.42 (higher than bulk silicate Earth’s Mg/Si = 1.23) yields a solidus similar to that of Earth’s undepleted mantle. However, HEX2, a composition with molar Ca/Al = 1.07 (higher than Earth Ca/Al = 0.72) has a solidus with a slope of ~10°C/kbar (versus ~15°C/kbar for Earth) and as result, has much lower melting temperatures than Earth. The majority of predicted adiabats point toward the likely formation of a silicate magma ocean for exoplanets with a mantle composition similar to HEX2. For adiabats that do intersect HEX2’s solidus, decompression melting initiates at pressures more than 4x greater than in the modern Earth’s undepleted mantle. The experimental partial melt compositions for these exoplanet mantle analogs are broadly similar to primitive terrestrial magmas but with higher CaO, and for the HEX2 composition, higher SiO2 for a given degree of melting.This first of its kind exoplanetary experimental data can be used to calibrate future exoplanet petrologic models and predict volatile solubilities, volcanic degassing, and crust compositions for exoplanets with bulk compositions and ƒO2 similar to those explored herein.
The Appreciation and Study of Qur’an Manuscripts from Southeast Asia: Past, Present, and Future
Authors: Gallop Annabel Teh 
Published: April 2021

The focus of this paper is not on theological aspects of the Qur’an, or on the study of the Qur’anic sciences in Southeast Asia over the past centuries, but rather to attempt to trace the path of the appreciation of old copies of the Qur’an in Southeast Asia as part of the historical record of the Islamic heritage of the region. In this light, Qur’an manuscripts are viewed as objects of material culture which can cast light on the societies which produced them, and as works of art which testify to the heights of artistic creativity in the region, for illuminated Qur’an manuscripts represent the pinnacle of achievements in the arts of the book in Southeast Asia. This historical record can be measured through a survey of how, where, when and by whom Qur’an manuscripts in Southeast Asia were collected, documented, studied and published, both in Southeast Asia itself and in the west.
Stimulus Taktil Kinestetik terhadap Perubahan Fisiologis Bayi Prematur dengan Perawatan Metode Kanguru
Authors: Marnita Elvi Febria , Mayetti Mayetti , Revilla Gusti 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh Stimulus Taktil Kinestetik (STK) terhadap perubahan fisiologis bayi prematur yang memperoleh Perawatan Metode Kanguru (PMK). Desain penelitian yang digunakan adalah Quasi Experiment dengan pretest-posttest two-group design. Sampel yang digunakan adalah sebanyak 39 bayi prematur yang dipilih dengan simple random sampling. Kelompok intervensi 20 bayi prematur dilakukan STK dengan durasi 15 menit dan kelompok kontrol 19 bayi prematur tanpa perlakuan. Pengukuran fisiologis pernafasan, denyut jantung, suhu dan berat badan pada kedua kelompok yang dilakukan hari ke 1 dan hari ke 5. Analisis uji statistik menggunakan Paired t-test dan Independent t-test. Hasil penelitian menunjukkan bahwa ada pengaruh perlakuan STK terhadap penurunan pernafasan, penurunan denyut jantung, peningkatan suhu dan peningkatan berat badan pada kelompok intervensi. Kelompok kontrol tanpa perlakuan menunjukkan ada pengaruh peningkatan suhu dan peningkatan berat badan. Tidak ada perbedaan yang signifikan pada kondisi fisiologis bayi prematur pada kelompok intervensi dan kelompok kontrol. Simpulan, pemberian perlakuan STK pada kelompok intervensi berpengaruh terhadap perubahan fisiologis bayi prematur.
Kata Kunci: Perawatan Metode Kanguru, Prematur, Stimulus Taktil Kinestetik
Penerapan Poster terhadap Kepedulian Perawat dalam Mengurangi Nyeri pada Prosedur Penusukan Tumit dan Pembuluh Darah Vena pada Neonatus
Authors: Purbasary Eleni Kenanga 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan poster terhadap kepedulian mengurangi nyeri pada prosedur penusukan tumit dan pembuluh darah vena. Desain penelitian yang digunakan dalam penelitian ini adalah quasi-eksperiment one-grup pre dan post-test. Hasil penelitian menunjukkan adanya peningkatan kepedulian perawat sebanyak 26 orang (49,1%), 95% CI pada rentang 0,35-0,63 dengan P-value sebesar 0,001. Simpulan, terdapat peningkatan kepedulian perawat dalam upaya mengurangi nyeri pada neonatus setelah penerapan poster.
Kata Kunci: Kepedulian Perawat, Nyeri, Penusukan Tumit, Poster
Pengetahuan Stimulasi Perkembangan Anak Usia Dini oleh Guru
Authors: Panzilion Panzilion , Padila Padila , Andri Juli 
Published: April 2021

Penelitian ini bertujuan untuk melihat gambaran pengetahuan stimulasi perkembangan anak usia dini oleh guru. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dengan desain penelitian crossectional dengan menggunakan Chi-Square. Populasi dalam penelitian ini adalah guru di PAUD Aisyiyah X Gading Cempaka sebanyak 20 responden. Teknik pengambilan sampel menggunakan teknik total sampling. Hasil penelitian menunjukkan bahwa gambaran pengetahuan guru PAUD tentang stimulasi perkembangan anak usia dini di PAUD Aisyiah X Kota Bengkulu dari 20 guru, kategori berpengetahuan baik berjumlah 11 responden (50%), kurang sebanyak delapan responden (20%) dan cukup sebanyak dua responden (10%). Simpulan, gambaran pengetahuan guru PAUD tentang stimulasi perkembangan anak usia dini di PAUD Aisyiah X Kota Bengkulu sebagian besar tergolong berpengetahuan baik.
Kata Kunci: Guru, Pengetahuan, Stimulasi Perkembangan
Optimalisasi Perawat Sehat dalam Memberikan Pelayanan Keperawatan Bermutu
Authors: Sudjiati Endang , Handiyani Hanny , Yetti Krisna , Suryani Cori Tri 
Published: April 2021

Penelitian ini bertujuan untuk mengembangkan panduan dan memberikan gambaran dalam mengupayakan optimalisasi kesehatan staf keperawatan di rumah sakit umum di Jakarta. Metode penelitian ini menggunakan pilot project mulai dari pengumpulan data, analisis masalah, penetapan prioritas masalah, penyusunan plan of action, implementasi dan evaluasi. Responden penelitian adalah kepala ruangan sebanyak 54 dan staf keperawatan sebanyak 479. Analisis masalah dilakukan dengan menggunakan diagram fishbone. Hasil analisis menunjukan bahwa ada masalah berupa belum optimalnya penerapan perilaku perawat sehat yang disebabkan belum adanya panduan perawat sehat, belum disusunnya SPO dan masih ada perawat yang belum mengetahui terkait dengan perilaku perawat sehat. Simpulan, solusi pemecahan masalah yaitu dengan membuat draft panduan perawat sehat di rumah sakit.
Kata Kunci: Optimalisasi Kesehatan, Panduan Perawat Sehat, Staf Keperawatan
STUDY OF NORMAL ANATOMICAL VARIATIONS IN PARA-NASAL SINUSES USING COMPUTED TOMOGRAPHY SCAN: A CROSS SECTIONAL STUDY FROM CENTRAL INDIA
Authors: Patil Sunil , Shendey Shweta , Ansari Ibrahim 
Published: April 2021

Background: The standard imaging in the assessment of the para-nasal sinuses is currently computed tomography scanning. This provides an applied anatomical view of the area as well as the common anatomical variants. The advancement and improvement of computed tomography scans has provided for a comprehensive evaluation of patients' para-nasal sinuses, allowing Functional Endoscopic Sinus Surgery surgeons to operate with a guide chart.
Objectives: To study normal anatomical variations in para-nasal sinuses using Computed Tomography.
Material and Methods: This research took place in a tertiary healthcare center's radiology department over the course of two years. Axial para-nasal sinuses cuts were taken using a multi-slice (128 slice scanner), followed by coronal and sagittal reconstruction.
Results: The most common anatomic variation, according to the findings, was nasal septal deviation. The rarest variation in our sample was Haller cell and pneumatized septum. There was also a close connection between unilateral Concha bullosa and contra-lateral septal deviation, as evidenced by the research.
Conclusion: A wide range of lesions can affect the para-nasal sinus area. Normal anatomical differences and congenital abnormalities in this area are significant because they can have pathological consequences or cause difficulty/complication during surgery.
Keywords: Para-nasal sinuses, Computed Tomography, Functional Endoscopic Sinus Surgery.
Pengaruh Penyemprotan Cetakan Alginat Dengan Sodium Hipoklorit 0,5%, Lidah Buaya 50% Terhadap Dimensi Model Positif
Authors: Eva Andy Fairuz Zuraida , Chotimah Chusnul , Abdi Muhammad Jayadi , Biba Andi Tenri , Amiruddin Maqhfirah , Sartinah Sartinah 
Published: April 2021

Pendahuluan: Bahan cetak alginat merupakan salah satu bahan cetak yang banyak digunakan di kedokteran gigi. Pada penggunaan alginat perlu diperhatikan penularan infeksi yang berasal dari bahan cetak. Tujuan Penelitian: Untuk mengetahui pengaruh penyemprotan hasil cetakan alginat dengan larutan Sodium Hipoklorit 0,5% dan Perasan Lidah Buaya (Aloe vera)50% terhadap dimensi model positif di laboratorium FKG UMI tahun 2018. Bahan dan Metode: Jenis penelitian True Eksperimental Laboratorium pada 27 sampel hasil cetakan alginat. Pengelompokan sampel terdiri dari 3 kelompok yaitu 1 kelompok tanpa perlakuan atau kontrol dan 2 kelompok perlakuan dengan teknik desinfeksi penyemprotan menggunakan larutan Sodium Hipoklorit 0,5% dan Perasan Lidah Buaya (Aloe vera)50% selama 10 menit. Pada masing-masing kelompok perlakuan terjadi perubahan stabilitas dimensional yang dilihat melalui pengukuran diameter dengan menggunakan jangka sorong digital. Hasil: Didapatkan hasil uji One Way Anova dimana hasil analisis data tersebut menunjukkan nilai p-value pada jarak AB yaitu 0,000 (p<0,05) kemudian untuk nilai p-value pada jarak BC yaitu 0,000 (p<0,05). Artinya , terdapat pengaruh yang signifikan pada penyemprotan hasil cetakan alginat dengan larutan Sodium hipoklorit 0,5% dan Perasan lidah buaya (Aloe vera) 50% terhadap dimensi model positif. Dengan demikian Ha diterima bahwa terdapat pengaruh yang signifikan pada penyemprotan larutan Sodium hipoklorit 0,5% dan Perasan lidah buaya (Aloe vera) 50% terhadap dimensi model positif.Kesimpulan: Penggunaan larutan Sodium Hipoklorit 0,5% dan Perasan Lidah Buaya (Aloe vera) 50% menyebabkan perubahan dimensi cetakan alginat.