bluuebunny/crossref_metadata_2025_split huggingface dataset:
Counselling as a calling: Meaning in life and perceived self‐competence in counselling students
Authors: Hurst Robert , Prescott Julie 
Published: April 2021

AbstractBoth meaning in life (MIL) and perceived self‐competence (PSC) have been linked to a sense of calling, and better well‐being. To the authors' knowledge, no study has examined MIL or PSC in counselling students. Current counselling students (N = 292) were asked whether studying counselling brought them MIL, and completed the Meaning in Life Questionnaire, and an adapted Perceived Competence Scale for Counselling Students (PCS‐CS). Results showed that students with a higher sense of MIL had a higher level of PSC. Over 95% of participants found meaning in their study of counselling, implying that many found it to be a calling. The PCS‐CS was found to be reliable, and implications include its potential usefulness in future research on PSC in counselling populations. With MIL and PSC being linked to better workplace well‐being, this study implies that trainee counsellors have high levels of these protective factors, with further research warranted to establish whether this is also the case for counselling professionals.
Anatomical‐functional discordance between quantitative coronary angiography and diastolic pressure ratio during wave‐free period
Authors: Nakamura Shun , Yonetsu Taishi , Hoshino Masahiro , Hada Masahiro , Yamaguchi Masao , Kanaji Yoshihisa , Sugiyama Tomoyo , Nakamura Taichi , Matsuda Junji , Hatano Yu , Umemoto Tomoyuki , Sasano Tetsuo , Kakuta Tsunekazu 
Published: April 2021

AbstractObjectivesThis study sought to determine the predictors of anatomical‐functional discordance between quantitative coronary angiography (QCA) derived diameter stenosis (QCA‐DS) and diastolic pressure ratio during wave‐free period (dPRWFP).BackgroundThe discrepancy between angiographical stenosis and physiological significance is frequently experienced in clinical practice. Although the anatomical‐functional discordance between angiography and fractional flow reserve (FFR) has been intensively investigated, that of resting index including dPRWFP remains to be elucidated.MethodsIn a total of 647 angiographically intermediate lesions with QCA‐DS between 30 and 70% in 502 patients, predictors of having QCA‐DS >50% and dPRWFP > 0.89 (QCA‐dPRWFP mismatch), and those of having QCA‐DS ≤50% and dPRWFP ≤ 0.89 (QCA‐dPRWFP reverse mismatch) were determined. FFR ≤0.80 was defined as positive FFR and the predictors of QCA‐FFR discordance were determined as well.ResultsQCA‐dPRWFP mismatch and reverse mismatch were observed in 27.5 and 17.6% of cases, respectively. The predictors of mismatch were non‐left anterior descending artery (LAD) lesion, large minimal lumen diameter, low baseline heart rate, and high coronary flow reserve (CFR), while those of reverse mismatch were LAD lesion, non‐culprit lesion of acute coronary syndrome, long lesion length, low left ventricular ejection fraction, and low CFR and index of microcirculatory resistance. Age, sex, and the culprit vessel of prior myocardial infarction were not significant determinants of QCA‐dPRWFP discordance unlike QCA‐FFR discordance derived from the same cohort.ConclusionsAnatomical‐functional discordance between angiography and dPRWFP was not uncommon. Predictors differed between QCA‐dPRWFP discordance and QCA‐FFR discordance.
Use of edge‐to‐edge percutaneous mitral valve repair for severe mitral regurgitation in cardiogenic shock: A multicenter observational experience (MITRA‐SHOCK study)
Authors: Falasconi Giulio , Melillo Francesco , Pannone Luigi , Adamo Marianna , Ronco Federico , Latib Azeem , Rahgozar Kusha , Carrabba Nazario , Valenti Renato , Citro Rodolfo , Stella Stefano , Ingallina Giacomo , Capogrosso Cristina , Scandroglio Mara , Ancona Francesco , Godino Cosmo , Denti Paolo , Castiglioni Alessandro , De Bonis Michele , Colombo Antonio , Lupi Laura , Branca Luca , Montorfano Matteo , Agricola Eustachio 
Published: April 2021

AbstractObjectivesThe aim of this study was to evaluate the impact of edge‐to‐edge PMVR on short and mid‐term clinical outcomes in patients with CS and severe MR.BackgroundSevere mitral regurgitation (MR) in the setting of cardiogenic shock (CS) is associated with three times higher risk of 1‐year mortality. In refractory CS, edge‐to‐edge percutaneous mitral valve repair (PMVR) can be a potential therapeutic option.MethodsWe retrospectively included consecutive patients with refractory CS and concomitant severe MR treated with MitraClip® system. CS was defined according to the criteria used in the SHOCK trial and procedural success according to Mitral Valve Academic Research Consortium (MVARC) criteria. The 30‐day and 6‐month mortality were the primary and secondary endpoints respectively.ResultsThirty‐one patients (median age 73 years [interquartile range, IQR 66–78], 25.8% female), STS mortality score 37.9 [IQR 30.4–42.4]), with CS and concomitant severe MR treated with edge‐to‐edge PMVR were retrospectively enrolled. Procedural success was 87.1%. Thirty‐day and 6‐month survival rates were 78.4 and 45.2% respectively. Univariate Cox Regression Model analysis showed that procedural success was a predictor of both 30‐day (HR = 0.12, 95% CI 0.03–0.55, p < .01) and 6‐month survival (HR = 0.22, 95% CI 0.06–0.84, p = .027).ConclusionsEdge‐to‐edge PMVR in patients with CS and concomitant severe MR was associated with good procedural safety and success with acceptable short and mid‐term survival rates. It could be considered a bailout option in this setting of patients.
Carotid artery ligation via sternotomy as a palliative surgery: Case report of advanced intramediastinal malignant soft tissue tumor
Authors: Eguchi Kohtaro , Kobayashi Kenya , Takano Tomonari , Ito Akiko , Sakai Azusa , Ikeda Atsuo , Matsumoto Yoshifumi , Omura Go , Matsumoto Fumihiko , Yoshimoto Seiichi 
Published: April 2021

AbstractUnder extreme conditions and in palliative settings, shared decision making with the patient is vital; narrative decisions beyond evidence could be considered. If there is a chance of symptom palliation, extended surgery should not be avoided merely because of the limited life expectancy.
Reactions of C60 with Pyridazine and Phthalazine
Authors: Hashikawa Yoshifumi , Li Hui , Murata Yasujiro 
Published: April 2021

AbstractCage‐opened bisfulleroids are one of suitable building blocks for making a large hole on fullerenes. This work focuses on the Diels‐Alder reaction of C60 with azines, among synthetic methods developed thus far, to provide bisfulleroids. Surprisingly, the computational study predicted that the reaction proceeds with normal electron demand in contrast to hitherto considered inverse‐electron‐demand pathway. The benzoannulation to the pyridazine ring, i. e., phthalazine, resulted in the remarkably shortened reaction time due to the better interaction between the HOMO of phthalazine and the LUMO of C60 as well as stronger 2,3‐diaza‐1,3‐butadiene character in the phthalazine as confirmed crystallographically. Contrary to expectations, the benzobisfulleroid was converted into corresponding orifice‐enlarged derivative via the photooxygenation slightly faster than the fulleroid derived from pyridazine.
Diffusion in Nanoporous Solids in the Focus of IUPAC – A Tribute to Jens Weitkamp
Authors: Gläser Roger , Kärger Jörg , Ruthven Douglas M. 
Published: April 2021

AbstractIn bidding farewell to Prof. Dr.‐Ing. Jens Weitkamp, we remember his many activities and his beneficial influence on the development of science, notably in the various fields of chemical technology and engineering. These activities include his engagement in support of the development of techniques dedicated to improvement of our understanding of the complex phenomenon of mass transfer in nanoporous materials, as both an ingenious scientist and a brilliant organizer and gifted leader of scientific alliances. The present contribution provides a brief introduction to the many facets of research in this field, with particular recognition of the most recent developments and Prof. Weitkamp's contributions.
Optimal design under complete class with ancillary functions
Authors: Hua Yi , Yang Min 
Published: April 2021

AbstractNonlinear models are challenging in optimal designs due to their complexity and lack of canonical forms. The complete class strategy provides a unified framework for studying optimal designs for nonlinear models. However, the current strategy does not apply to many models under this framework. In this article, we propose a tool called ancillary functions as an extension to the complete class strategy. We also provide results on minimally supported designs with proper conditions. We demonstrate this tool with two‐parameter dose–response models, which include the Beta‐Poisson model, the complementary log–log model, and the skewed logit model. The results of this article add to the previous complete class framework and make the minimally supported design available for more nonlinear models that were previously not feasible.
Outcomes of orbital exenteration for craniofacial lesions
Authors: Traylor Jeffrey I. , Christiano Lana D. , Esmaeli Bita , Hanasono Matthew M. , Yu Peirong , Suki Dima , Zhang Wen , Raza Shaan M. , Hanna Ehab Y. , DeMonte Franco 
Published: April 2021

BACKGROUNDOrbital exenteration (OE) is an ablative procedure used in the management of malignancies of the orbit of either primary or secondary origin. Publications evaluating this procedure have suffered from small patient numbers, heterogeneity of pathologies, and poor patient follow‐up. The purpose of this study was to assess patient outcomes in a large cohort of patients undergoing OE at a tertiary cancer center.METHODSA retrospective review was conducted of 180 consecutive patients who underwent OE at the authors' institution. Overall survival (OS) was the primary end point measured in the study. Time to locoregional recurrence (progression‐free survival [PFS]) and disease‐free survival were secondary end points.RESULTSBetween the years 1993 and 2011, 180 consecutive patients received OE for craniofacial malignancy at the authors' institution. The median follow‐up for the cohort was 9.7 years (116 months). The median OS was 73 months, and the median PFS was 96 months. The presence of perineural invasion was associated with shorter OS (P = .01) and PFS (P < .01). Magnetic resonance imaging was predictive of perineural invasion (P < .01). Positive margins were associated with shorter PFS than negative margins (P < .01) but with no change in OS (P = .15). The overall complication rate was 15%. The major complication rate (Clavien‐Dindo 3b or greater) was 2.8% (n = 5), and there was 1 death observed (0.6%).CONCLUSIONSUsed judiciously in the setting of a multidisciplinary management plan, OE for tumor control is a safe therapy.LAY SUMMARY

Between the years 1993 and 2011, 180 consecutive patients received orbital exenteration for craniofacial malignancy at the MD Anderson Cancer Center. The median follow‐up for the cohort was 9.7 years.

The presence of perineural invasion was associated with shorter overall survival (P = .01) and progression‐free survival (P < .01). Magnetic resonance imaging was predictive of perineural invasion (P < .01).

Positive margins were associated with shorter progression‐free survival than negative margins (P < .01). The overall complication rate was 15%. The major complication rate (Clavien‐Dindo 3b or greater) was 2.8% (n = 5).
Parallel spreadsheet evaluation and dynamic cycle detection
Authors: Bock Alexander Asp 
Published: April 2021

SummaryIt was estimated there would be 72 million users using spreadsheets monthly in 2017 some of which build complex financial, scientific, and mathematical models. Most of these end‐users are not trained IT professionals but domain experts. In the age of multicore computing and ever‐increasing amounts of data, how can end‐users access this powerful, parallel hardware to accelerate spreadsheet computation? Some existing solutions are usually not fully automatic and require a level of interaction from end‐users to facilitate parallel execution. Ideally, an end‐user tool would transparently exploit the underlying hardware and automatically discover available parallelism in the spreadsheet without any required interaction. This article presents an algorithm for automatic parallel evaluation of the cells in a spreadsheet and dynamic, parallel cycle detection. It is implemented in the Funcalc research spreadsheet application which supports higher‐order functions in the spreadsheet paradigm. Altogether, this promises a powerful and expressive platform for end‐user development. Our results on a 48 logical core machine show a maximum 7–14× speed‐up on a set of benchmark spreadsheets and a maximum 21–32× speed‐up on a set of synthetic spreadsheets with predefined topologies.
Solid‐State Synthesis of (Ph4P)MI3 (M=Eu2+, Sr2+, Sn2+) and Investigation of Photoluminescence Properties of Green Emitting Phosphor
Authors: Siai Amira , Ströbele Markus , Enseling David , Jüstel Thomas , Meyer Hans‐Jürgen 
Published: April 2021

AbstractThis work reports a solid‐state preparation of hybrid tetraphenylphosphonium (Ph4P+) compounds (Ph4P)MI3 (M=Eu2+, Sr2+ and Sn2+). The new materials (Ph4P)EuI3 and (Ph4P)SrI3 are found to crystallize isotypically in the trigonal space group
, where Eu2+ and Sr2+ ions exhibit similarly two different crystallographic positions and occupy the centers of trigonal antiprismatic sites. The corresponding compound (Ph4P)SnI3 was accordingly prepared by solid‐state reaction to yield yellow crystals which crystallize in a monoclinic structure (P21/c). The luminescent properties of (Ph4P)EuI3 were investigated and the results revealed that Eu2+ displays an intensive green band emission peaked at 536 nm. The radiative decay time determined upon excitation at 536 nm is 508 ns.
Photoluminescent Metallaprisms with (p‐Cymene)Ru‐Corners and Bis(β‐diketone) Pillars
Authors: Yan Ming‐Jie , Huang Sheng‐Li , Yang Guo‐Yu 
Published: April 2021

AbstractFour metallaprisms were synthesized by the selective combination of (p‐cymene)Ru‐corners, bis(β‐diketone) pillars, and multi‐functional pyridyl linkers. They have large cavities and exhibit photoluminescence in CH2Cl2solvent, particularly the employment of AIE‐active ligand tetra‐(4‐pyridylphenyl)ethylene (TPPE) endows one of them with AIE properties.
New progress achieved in seasonal dynamics of dissolved organic carbon of permafrost peatland through Chinese–United States EcoPartnership relationships
Authors: Wang Xianwei , Song Changchun , Sun Li , Song Yanyu , Hou Aixin , Tan Wenwen 
Published: April 2021

AbstractPermafrost peatland plays an important role in the global carbon (C) cycle, and dissolved organic carbon (DOC) is one of the most important components to C budgets in this system. Through the Chinese–United States EcoPartnership program, Dr Xianwei Wang, Li Sun, and Prof Changchun Song et al. from the Northeast Institute of Geography and Agroecology of Chinese Academy of Sciences and Prof Aixin Hou from the Louisiana State University observed dynamics of DOC concentrations and specific ultraviolet absorbance at 254 nm (SUVA254) obtained from soil porewater of permafrost peatlands for two growing seasons in the Great Hing'an Mountains, Northeast China. Soil porewater DOC concentrations varied greatly with depths during the growing season, ranging between 22.08 and 65.02 mg L−1. There was no significant relationship between DOC concentrations and SUVA254. DOC concentrations were higher in autumn and increased as the seasonal thaw depth increased. DOC concentrations of supra‐permafrost water at freeze–thaw boundary were also higher than those at the other soil depths. Temperature and thawing depth had been shown to affect DOC concentrations at different soil depths. Our finding suggests that warming and deepening of the active layer likely increase the DOC productions in the permafrost peatland, which may influence the C balance in these C‐enriched ecosystems.
Neurophysiological and functional neuroanatomical coding of statistical and deterministic rule information during sequence learning
Authors: Takács Ádám , Kóbor Andrea , Kardos Zsófia , Janacsek Karolina , Horváth Kata , Beste Christian , Nemeth Dezso 
Published: April 2021

AbstractHumans are capable of acquiring multiple types of information presented in the same information stream. It has been suggested that at least two parallel learning processes are important during learning of sequential patterns—statistical learning and rule‐based learning. Yet, the neurophysiological underpinnings of these parallel learning processes are not fully understood. To differentiate between the simultaneous mechanisms at the single trial level, we apply a temporal EEG signal decomposition approach together with sLORETA source localization method to delineate whether distinct statistical and rule‐based learning codes can be distinguished in EEG data and can be related to distinct functional neuroanatomical structures. We demonstrate that concomitant but distinct aspects of information coded in the N2 time window play a role in these mechanisms: mismatch detection and response control underlie statistical learning and rule‐based learning, respectively, albeit with different levels of time‐sensitivity. Moreover, the effects of the two learning mechanisms in the different temporally decomposed clusters of neural activity also differed from each other in neural sources. Importantly, the right inferior frontal cortex (BA44) was specifically implicated in visuomotor statistical learning, confirming its role in the acquisition of transitional probabilities. In contrast, visuomotor rule‐based learning was associated with the prefrontal gyrus (BA6). The results show how simultaneous learning mechanisms operate at the neurophysiological level and are orchestrated by distinct prefrontal cortical areas. The current findings deepen our understanding on the mechanisms of how humans are capable of learning multiple types of information from the same stimulus stream in a parallel fashion.
Development, translation, and preliminary validation of the neck dissection assessment tool
Authors: Yang Nathan , Mercier Érika , Guertin Louis , Bissada Eric , Christopoulos Apostolos , Olivier Marie‐Jo , Tabet Jean‐Claude , Chiesa‐Estomba Carlos Miguel , Ayad Tareck 
Published: April 2021

AbstractBackgroundThe objective was to develop an assessment tool to evaluate residents' competency for neck dissection and provide preliminary evidence of feasibility, reliability, and validity.MethodsSix surgeons developed a neck dissection assessment tool using a modified Delphi method and evaluated 58 neck dissections from six junior and six senior otolaryngology residents.ResultsThe assessment tool uses a double checklist: a previously validated global rating scale (GRS) and a task‐specific checklist (TSC). Use of the instrument appeared feasible and the average scores on the GRS and TSC differed significantly between junior and senior residents. The Pearson correlation coefficient between both checklists was 0.87. Intraclass correlation (ICC) for inter‐rater reliability was 0.69 for the GRS, and 0.80 for the TSC.ConclusionThis study provides preliminary evidence of feasibility, reliability, and validity for the first neck dissection assessment tool and provides a foundation for further psychometric analysis and research.
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Authors: Jiang Yu , Wang Yichun , Ni Jiangfeng , Li Liang 
Published: April 2021

Molybdenum‐based materials exhibit a high capacity and rich reaction chemistry for sodium, but their potential in sodium‐ion batteries has been plagued by several technical challenges. In this review, the authors present a state‐of‐the‐art overview of the research progress of molybdenum‐based materials for sodium storage, highlight materials engineering strategies that are capable of addressing these challenges, and offer valuable insights into their further development in practice (DOI: 10.1002/inf2.12175).
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Lithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case‐based systematic analysis
Authors: Łukawska Emilia , Frankiewicz Dorota , Izak Monika , Woźniak Aldona , Dworacki Grzegorz , Niemir Zofia I. 
Published: April 2021

AbstractDespite the progress made in treating bipolar and unipolar affective disorders, lithium carbonate is still a common drug in psychiatric practice. Lithium‐related renal side effects include nephrogenic diabetes insipidus, chronic tubulointerstitial nephropathy, and acute kidney injury (AKI). Nephrotic syndrome (NS) is an uncommon but severe complication of lithium treatment. We present a 49‐year‐old female treated with lithium carbonate due to a recurrent depressive disorder who developed NS during this therapy. NS spontaneously remitted after the drug withdrawal. Since her lithium serum levels were within the recommended values, we performed a retrospective analysis of lithium‐induced NS cases trying to determine causes predisposing to the NS development, underlying histopathology, and preservation or irreversible loss of kidney function. This analysis revealed that in lithium‐induced NS with AKI, lithium serum level was the key determinant of AKI development (the β coefficient = 0.8499 with a confidence interval ranging from 0.7452 to 0.9546 and p value < 0.0001). In these cases, the underlying pathology was mainly minimal change disease (MCD), which was quickly reversible upon the drug withdrawal. The development of chronic kidney disease (CKD) seemed to be associated with lithium therapy duration. However, the multiple regression analysis for CKD as the dependent variable showed that the decisive factor was focal segmental glomerulosclerosis (FSGS) as the underlying pathology (the β coefficient = 0.7866 with a confidence interval ranging from 0.600 to 0.9704 and the p value < 0.0001). Thus, we conclude that in lithium‐induced NS/AKI, serum lithium levels contribute to these complications, while FSGS lesions are responsible for CKD's disease progression.
A combined Monte Carlo/DFT approach to simulate UV‐vis spectra of molecules and aggregates: Merocyanine dyes as a case study
Authors: Tirri Bernardino , Mazzone Gloria , Ottochian Alistar , Gomar Jerôme , Raucci Umberto , Adamo Carlo , Ciofini Ilaria 
Published: April 2021

AbstractThe combination of a Monte Carlo (MC) sampling of the configurational space with time dependent‐density functional theory (TD‐DFT) to estimate vertical excitations energies has been applied to compute the absorption spectra of a family of merocyanine dyes in both their monomeric and dimeric forms. These results have been compared to those obtained using a static DFT/TD‐DFT approach as well as to the available experimental spectra. Though suffering of the limitations related to the use of DFT and TD‐DFT for this type of systems, our data clearly show that the classical MC sampling provides a suitable alternative to classical molecular dynamics to explore the structural flexibility of these donor‐acceptor (D‐π‐A) chromophores enabling a realistic description of the potential energy surface of both their monomers and aggregates (here dimers) and thus of their spectra. Overall, the combination of MC sampling with quantum mechanics (TD‐DFT) calculations, carried out in implicit dioxane solvent on random snapshots, provides a workable compromise to solve the combined challenge of accuracy and time‐consuming problem not only for merocyanines momers, but also for their dimers, up to now less investigated. Indeed, the simulated absorption spectra fairly agree with the experimental ones, suggesting the general reliability of the method.