bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radioactive 125I Seed Implantation for Recurrent Cervical Carcinoma After Surgery and Radiotherapy: A Case Report
Authors: Qiao Shiqi , Zhang Hongtao , Di Xuemin , Zhao JinXin , Wang Juan 
Published: December 2021

Abstract
Background: The prognosis of cervical cancer is remarkable, but there are still instances of pelvic and/or extrapelvic recurrence after radical hysterectomy with platinum-based chemoradiotherapy. Sixty percent of the patients with radiotherapy (RT) failure have pelvic recurrence, and 80% of them relapse within two years after treatment. Recurrent cervical cancer seriously affects the prognosis and survival rate of patients. Due to the dose limitation for normal tissue, it is difficult to deliver a sufficient number of doses to recurrent lesions through reirradiation. With the rapid development of brachytherapy technologies such as three-dimensional afterloading brachytherapy, interstitial brachytherapy and radioactive 125I seed implantation, the overall survival (OS) of patients with recurrent cervical cancer has been improving. In the present study, a case in which the patient was successfully treated with radioactive 125I seed implantation is reported.Case presentation: The patient, a 47-year-old woman, was initially diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer and received preoperative radiotherapy, radical hysterectomy, pelvic lymph node dissection and postoperative radiotherapy. After 95 months of follow-up, retroperitoneal lymph node metastasis and edema of the left lower limb . The size of the retroperitoneal lesion was 2.3 × 2.0 cm, and the size of the left supraclavicle lesion was 2.0 × 1.5 cm. Radioactive 125I seed implantation was performed for retroperitoneal lymph node metastasis and left supraclavicular metastasis. Paclitaxel and cisplatin chemotherapy were given after the operation. Three months after implantation, the size of the retroperitoneal focus was 1.5 × 1.1 cm, and the size of the left supraclavicular lesion was 1.0 × 0.6 cm. Thirteen months after implantation, according to the RECIST standard, the therapeutic effect reached CR. At the time of submission, the patient's progression-free survival was 6 years and 4 months.Conclusions: CT-guided 125I seed implantation is a safe, effective, and minimally invasive method for treating patients with recurrent cervical cancer after radiotherapy. The response of this patient indicates that 125I seed implantation can be used as a complementary treatment for recurrent cervical cancer after chemoradiotherapy and may also prove to be reliable for comprehensive treatment of cervical cancer.
The Effect of SBAR Communication on Nurse Attitude and Behavior in Increasing Patient Safety in KRMT Wongsonegoro Hospital, Semarang
Authors: Girsang Ermi , Nasution Sri Lestari Ramadhani , Fatmah Annisya Ul , Cristy Melyala 
Published: December 2021

Abstract
Introduction: WHO officially published the Nine Life Saving Patient Safety, which one is correct communication during handover using the SBAR method. SBAR is considered a clear sign and secure method of communication for problem solving among various disciplines in the medical environment and a simple way of sharing patient information with other medical professionals. Methods: This research is a quasi-experimental study with a pretest-posttest design with control group design, the results of the research were processed using paired sample t-test. The data collection of this research uses a checklist of observation sheets to assess the ability of nurses to communicate SBAR, attitudes and behavior of nurses using a questionnaire. Result and discussion: this study showed a significant difference in the attitudes and behavior of nurses in improving patient safety after being given SBAR communication materials with p-value < 0.05. Conclusion: This study showed significant differences in the attitudes and behavior of nurses after being given SBAR communication training in the intervention group. Meanwhile, the control group showed a non-significant difference This showed that SBAR communication materials affect the attitudes and behavior of nurses in improving patient safety.
Comorbid Symptoms of Internet Addiction Among Adolescents with and Without Autism Spectrum Disorder: A Comparative Study
Authors: Kawabe Kentaro , Horiuchi Fumie , Hosokawa Rie , Nakachi Kiwamu , Soga Junya , Ueno Shu-ichi 
Published: December 2021

Abstract
Over the last decade, research into the characteristics of problematic internet use among individuals with autism spectrum disorder (ASD) has greatly increased. We investigated Internet addiction’s prevalence and compared its related factors, among adolescents with and without ASD. Outpatients (n = 102) aged 12–15 years, completed the Basic Information Questionnaire, Internet Addiction Test, and Quick Inventory of Depressive Symptomatology Self-Report Japanese version. Their parents completed the Social Responsiveness Scale-2 and Attention Deficit Hyperactivity Disorder Rating Scale-IV. Scores of both (ASD and without ASD) groups were analyzed. Prevalence of Internet addiction was 40.0% in ASD group and 23.9% in without ASD group. Statistically related factors of Internet addiction were not found in the ASD group. However, factors of Internet addiction were related to the QIDS and ADHD-RS scores in the without ASD group. In conclusion, factors related to Internet addiction differed for ASD patients and without ASD patients.
A Qualitative Study Exploring Barriers and Facilitators to Establishing Nurse-led, Multidisciplinary Psychological Care for Trauma Patients: Experiences From Doctors and Nurses
Authors: Leng Yanan , Wu Ying , Wang Zonghua , Zhou Xiaoping , Liao Jianmei 
Published: December 2021

Abstract
BackgroundTrauma patients are often in a state of psychological stress, experiencing helplessness, sadness, frustration, irritation, avoidance, irritability and other adverse emotions. Doctors and nurses are at the forefront of caring trauma patients and they play a crucial role in psychological supports and mental health care. However, few qualitative studies had based on the framework of the Theory of Planned Behavior (TPB) to explore the experiences in providing psychological care for trauma patients. We examined attitudinal, normative, and control beliefs underpinning medical staffs’ decisions to perform psychological care.MethodA qualitative study of in-depth semi-structured interviews was conducted among 14 doctors and nurses engaging in trauma care. The participants came from six tertiary hospitals in Chongqing, China. Data analysis was performed using the approach of Colaizzi. According to the framework of TPB, the researchers identified and summarized the themes.ResultsImportant advantages (mutual trust, patients' adherence and recovery), disadvantages (workload, short-term ineffective, practice unconfidently), referents (supportive: managers, patients, kinsfolk, nursing culture; unsupportive: some colleagues and patients), barriers (insufficient time or energy, resources situations), and facilitators (access to psychologist, training/education, reminders) were identified. Some demands, such as training diversity, multidisciplinary cooperation and families' support, reflected by doctors and nurses were important for them to carry out psychological care.ConclusionAccording to the TPB, this article explored the internal and external promotion and hindrance factors that affecting the intentions and behaviors of doctors and nurses in implementing psychological care for trauma patients. We also focused on the experience and demands of health professionals in conducting psychological care, which could provide references for managers to formulate corresponding psychological care procedures and norms.
Network Analysis Reveals Dysregulated Functional Patterns in Type II Diabetic Skin
Authors: Liu Chunan , Ram Sudha , Hurwitz Bonnie L. 
Published: December 2021

Abstract
Skin disorders are one of the most common complications of type II diabetes (T2DM). Long-term effects of high blood glucose leave individuals with T2DM more susceptible to cutaneous diseases, but its underlying molecular mechanisms are unclear. Network-based methods consider the complex interactions between genes which can complement the analysis of single genes in previous research. Here, we use network analysis and topological properties to systematically investigate dysregulated gene co-expression patterns in type II diabetic skin with skin samples from the Genotype-Tissue Expression database. Our final network consisted of 8,812 genes from 73 subjects with T2DM and 147 non-T2DM subjects matched for age, sex, and race. Two gene modules significantly related to T2DM were functionally enriched in the pathway lipid metabolism, activated by PPARA and SREBF (SREBP). Transcription factors KLF10, KLF4, SP1, and microRNA-21 were predicted to be important regulators of gene expression in these modules. Intramodular analysis and betweenness centrality identified NCOA6 as the hub gene while KHSRP and SIN3B are key coordinators that influence molecular activities differently between T2DM and non-T2DM populations. We built a TF-miRNA-mRNA regulatory network to reveal the novel mechanism (miR-21-PPARA-NCOA6) of dysregulated keratinocyte proliferation, differentiation, and migration in diabetic skin, which may provide new insights into the susceptibility of skin disorders in T2DM patients. Hub genes and key coordinators may serve as therapeutic targets to improve diabetic skincare.
Simultaneous determination of gross alpha/beta activities in water by liquid scintillation counting and its applications in the environmental monitoring
Authors: Li Xiaoyun , Wang Shaolin , Lou Hailin , Pan Jingshun , Dong Qian , Zheng Yifan , Chen Ling 
Published: December 2021

Abstract
Based on the standards of ISO11704-2018 and ASTM D7283-17, a method for simultaneous determination of gross alpha and gross beta activity concentrations in water by liquid scintillation counting (LSC) was established, which can be applied to various types of water samples in routine monitoring, such as drinking water, groundwater, geothermal water, seawater, and radioactive wastewater. The sample’s pH value and concentrated volume must be controlled to avoid quenching as much as possible. The validation tests show that the deviations of gross alpha and gross beta activities can satisfy quality control requirements in a wide range of activity ratios. For the actual samples, the measurement results of the LSC method are in good agreement with those of the thick source method. Moreover, the LSC method performs better in detection limit and a simpler pretreatment process than the thick source method.
Valorization of Oil Waste for Biodetergent Production Using Serratia Marcescens N2 and Gamma Irradiation Assisted Biorecovery
Authors: Elkenawy Nora M. , Gomaa Ola M. 
Published: December 2021

Abstract
The aim of the present work is to valorize previously used frying oil and use it as biodetergent. Serratia marscens N2 valorized 20% used oil and 8% cell concentration, the biosurfactant produced was a negatively charged lipopeptide with surface tension of 26.8 mN/m. Gamma radiation was used to obtain the higher yield of the biosurfactant by exposing the cells after growth under optimal conditions to low dose gamma radiation. The results showed that the use of radiation led to an increase in the amount of biosurfactant, and the biorecovery took place in a shorter time than usual. The chemical or functional form of the substance did not change at doses of 500 and 1000 gray, while there was a change in production and chemical and functional form at the dose of 2000 gray. The produced biosurfactant was used before and after irradiation to wash oil soiled cloths, the results showed 87% removal at 60oC under stirring conditions. Skin irritation tests performed on experimental mice showed that the surfactant does not cause any inflammation or red spots. Optical images of cloth patches showed no effect on fabric threads post washing the oil soiled cloth patches with biosurfactant. This study proved that 1) previously used oil can be bioconverted into biosurfactant and 2) the use of low doses gamma radiation results in an increase in biosurfactant yield by creating holes in the bacterial cell wall, which helps to recover more quantities of the biosurfactant without change in its chemical or functional form.
Fenton Reaction Facilitates The Fungal Infection On The Unicellular Alga Haematococcus Pluvialis and Discovery of a Biosafe and Environment-Friendly Chemical That Blocks The Infection
Authors: Yan Hailong , Ma Haiyan , Li Yanhua , Zhao Liang , Lin Juan , Jia Qikun , Hu Qiang , Han Danxiang 
Published: December 2021

Abstract
Background

The green microalga Haematococcus pluvialis is used as cell factories for producing astaxanthin, the high-value natural compound with multiple biological functions. However, H. pluvialis is prone to the infection by a parasitic fungus Paraphysoderma sedebokerense, which is the most devastating threat to the mass culture of H. pluvialis all over the world. Little is known for the mechanisms underlying the infection process, though it is of great essential for developing effective measures to mitigate the pathogen threatening for the natural astaxanthin industry.
Results

We observed that there were heat-stable substances with small molecular weight produced during the infection process, which significantly stimulated the parasitism process and enhanced the susceptibility of H. pluvialis cells to the pathogen. Systematic approaches including multi-omics, biochemical and imaging analysis were deployed to uncover the identity of the metabolites and the underlying mechanisms. Two metabolites, 3-hydroxyanthranilic acid and hordenine were identified and proved to stimulate the infection via driving fenton reaction mediated oxidative stress to H. pluvialis. The reaction generated hydroxyl radicals to disrupt the subcellular components of the algal cells and to make the algal cells more susceptible to the infection. Based on these findings, a biosafe and environment-friendly antioxidant butylated hydroxyanisole was selected to inhibit the fungal infection, which completely abolished the infection at 12 ppm.
Conclusions

This study provide for the first time, a framework to dissect the functions of secondary metabolites in the interaction between the unicellular algal H. pluvialis and its fungi parasite, indicating that oxidative degradation is a strategy used for the fungal infest. Eliminating the oxidative burst through adding antioxidant butylated hydroxyanisole could be an effective measure to reduce parasitic infection in H. pluvialis mass culture.
Interaction Between Caveolin-1 Polymorphism with Dietary Fat Quality Indices and the Relationship with Visceral Adiposity Index (VAI) and Body Adiposity Index (BAI) Among Overweight and Obese Women: A Cross-Sectional Study
Authors: Ensaf Rasool Ghaffarian , Shiraseb Farideh , Mirzababaei Atieh , Clark Cain , Mirzaei Khadijeh 
Published: December 2021

Abstract
Background & Aims:

Caveolin-1(CAV-1) in adipocyte tissue, and other parts of body, possess numerous biological functions. In the present study, we sought to investigate the interaction between CAV-1 polymorphism with dietary fat quality indices and the relationship with visceral adiposity index (VAI) and body adiposity index (BAI) among overweight and obese women.
Methods

This study was conducted on 386 women, aged 18-48 years old. Biochemical measurements were measured by standard protocols. We used a food frequency questionnaire (FFQ) to calculate the dietary intake and the indices of dietary fat quality intake. Anthropometric values and body composition were measured by standard methods. Finally, the CAV-1 genotype was measured using PCR-RFLP method.
Results

We found a marginally significant difference in waist-to-hip ratio (WHR) (P=0.06) and BAI (P=0.06) of participants, after adjusting with potential cofounders. For dietary intakes, after adjusting with the energy intake, mean differences in biotin (P=0.04) and total fiber (P=0.06) were significant and marginally significant, respectively. The interaction between two risk allele genotype group (AA) with omega-6 to omega-3 ratio (W6/W3) on BAI, after adjustment with potential cofounders (age, physical activity, energy intake, education), was marginally positive (β = 14.08, 95%CI= -18.65,46.81, P= 0.07). In comparison to the reference group (GG), there was a positive interaction between the two risk allele (AA) with W6/W3 ratio on VAI (β = 2.81, 95%CI= 1.20,8.84, P= 0.06) in the adjusted model.
Conclusions

We found that there may be an interaction between CAV-1 genotypes with dietary quality fat indices on VAI and BAI among overweight and obese women.
Loss of Tau Expression Attenuates Neurodegeneration Associated with α-Synucleinopathy
Authors: Vermilyea Scott C. , Christensen Anne , Meints Joyce , Singh Balvindar , Martell-Martínez Héctor , Karim Md. Razaul , Lee Michael K 
Published: December 2021

Abstract
Background: Neuronal dysfunction and degeneration linked to a-synuclein (aS) pathology is thought to be responsible for the progressive nature of Parkinson’s Disease and related Dementia with Lewy Bodies. Studies indicate to bidirectional pathological relationships between aS pathology and tau abnormalities. We recently showed that A53T mutant human aS (HuaS) can cause post-synaptic and cognitive deficits that require microtubule-associated protein tau expression. However, the role of tau in development of aS pathology and subsequent neuronal dysfunction has been controversial. Herein, we set to determine the role of tau in the onset and progression of aS pathology (a-synucleinopathy) using a transgenic mouse model of a-synucleinopathy lacking mouse tau expression. Methods: Transgenic mice expressing A53T mutant HuaS (TgA53T) were crossed with mTau-/- mice to generate TgA53T/mTau-/-. To achieve uniform induction of a-synucleinopathy in mice, we used intramuscular injections of aS preformed fibrils (PFF) to non-transgenic (nTg), TgA53T, TgA53T/mTau-/-, and mTau-/- mice. Motor behavior was analyzed at 70 days post inoculation (dpi) of PFF and tissues for biochemical and neuropathological analysis were collected at 40 dpi, 70 dpi, and end stage. Results: Loss of tau expression significantly delayed onset of motor deficits in the TgA53T model and delayed a-synucleinopathy disease progression, as evidenced by a significant reduction in histopathological and behavioral markers of neurodegeneration and disease, and a significant improvement in survival. In vitro application of PFF to primary mouse hippocampal neurons demonstrated no changes in PFF uptake and processing or pS129 aS aggregation as a function of tau expression. However, PFF-induced neurotoxicity, including morphological deficits in nTg neurons, were prevented with tau removal. Conclusions: Collectively, our data suggest that tau is likely acting downstream of aS pathology to affect neuronal homeostasis and survival. This work further supports the investigation of tau in a-synucleinopathies to identify novel disease-modifying therapeutic strategies.
Prognostic Significance of Globulin/Low-Density Lipoprotein Ratio In Patients With Hepatocellular Carcinoma After Local Ablative Therapy
Authors: Qiao Wenying , Wang Qi , Li Jianjun , Yuan Chunwang , Guo Dandan , Zhu Tong , Zang Chaoran , Liu Biyu , Wang Qi , Wang Wen , Zhang Yonghong 
Published: December 2021

Abstract
Background: Low-density lipoprotein (LDL) and globulin have been found to be predictors for some malignant tumors, but their predictive value in hepatocellular carcinoma (HCC) has hardly to be elucidated. This study assessed the prognostic significance of globulin to low-density lipoprotein ratio (GLR) in HCC patients before ablation.Materials and methods: This study analyzed 312 HCC patients hospitalized and underwent ablative treatment in Beijing You 'an Hospital, Capital Medical University, from January 1, 2012 to January 1, 2017. Cox regression analysis was used to assess the factors independently associated with recurrence and survival. The optimal cut-off value and prognostic role of GLR and other markers were evaluated via the receiver operating characteristic-ROC curves and the Youden index. Overall survival (OS) and recurrence-free survival (RFS) were calculated by Kaplan-Meier analysis, and compared between groups using the log-rank.Result: Univariate and multivariate analysis found that the tumor number (HR: 1.676;95%CI: 1.113-2.526), tumor size (HR: 1.967;95%CI: 1.251-3.092), GLR (HR: 1.028;95%CI: 1.004-1.052) were independent risk factors of relapse; while etiology (HR: 1.328;95%CI: 1.052-1.677), tumor number (HR: 1.615;95%CI: 1.015-2.570), tumor size (HR: 2.061; 95%CI: 1.243-3.418), Fib (HR: 0.73; 95%CI: 0.535-0.996) and GLR (HR: 1.031;95%CI: 1.003-1.06) were related to overall survival. We classified the patients into groups with high and low levels of GLR based on the optimal cut-off value of GLR identified by generating receiver operating characteristics (ROC) curve. The cumulative 1-, 3-, and 5-year RFS rates in the low GLR group were 76.4%, 53.8% and 43.4%, while those in the high GLR group were 71%, 31% and 22%, respectively (P <0.001). Concerning OS, the low GLR group showed a 1-, 3- and 5-year OS of 99.5%, 92.0% and 80.2% versus 98%, 73% and 63% for the high GLR group (P <0.001). Finally, patients were stratified by GLR and tumor size. The outcomes revealed that patients in group A (GLR<16.54 and tumor size ≤30mm) showed better prognosis than group B (GLR≥16.54 and tumor size≤30mm or GLR<16.54 and tumor size >30mm) and group C (GLR≥16.54 and tumor size >30mm) (P <0.001). Conclusions: Preoperative GLR ratio could serve as a biomarker to predict prognosis in HCC patients who underwent complete ablation.