bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel method for high‐density porous polyethylene ear reconstruction stent remodeling to achieve high satisfactory outcomes
Authors: Guo Rong , Ying Jianghui , Yuan Xiao , Xi Tingting , Xiong Jiachao , Jiang Hua 
Published: December 2021

AbstractObjectiveWe aimed to explore a novel method for ear reconstruction stent remodeling to achieve high patient satisfactory outcomes.MethodsThis study is a retrospective review of patients with congenital or acquired ear defects who were prepared for one‐stage ear reconstruction with high‐density porous polyethylene stent between May 2020 and May 2021. A standardized data collection template was used to collect related variables. In this study, the detailed reconstruction surgery process is carefully described, and the postoperative healing process of the ear reconstruction was closely observed.ResultsA total of 26 patients for one‐stage ear reconstruction with high‐density porous polyethylene stent or autogenous costal cartilage scaffolds were admitted to the department of plastic surgery in our hospital between May 2020 and May 2021. All patients were followed until their ear flaps were alive and details of the ear shape were revealed. The patients with new remolding method were no severe complications and only a patient had stent exposure, and were highly satisfied with both appearance and function.ConclusionsThe application of novel remodeling method is a promising way for ear reconstruction stent shaping with little postoperative complication and excellent postoperative patient satisfaction.
Relationism and the Problem of Publicity
Authors: Valente Matheus , Verdejo Víctor M. 
Published: December 2021

AbstractAccording to a recently developed family of relational views, whether two concepts C1and C2are the same is a matter of an external relation in which their tokens stand. In this paper, we highlight the chief contributions of Relationism in the elucidation of concept sameness, present a set of arguments to the effect that relational accounts of concept sameness fail to accommodate a substantive notion of concept publicity, and offer a diagnosis of this result. We conclude that the strengths of non‐relational approaches will also need to be considered in order to fully capture what it means for a concept to be public.
Perceived changes in social contact during COVID‐19 pandemic in the United States
Authors: Lee Ji Hyun , Luchetti Martina , Aschwanden Damaris , Sesker Amanda A. , Strickhouser Jason E. , Terracciano Antonio , Sutin Angelina R. 
Published: December 2021

AbstractThe COVID‐19 pandemic and its restrictions have led to a shift in how people connect with others. This study investigated (a) profiles of social contact change across social ties and modes of contact, (b) predictors of these profiles, and (c) the association between these profiles and mental health during the pandemic. Participants (N = 2,098; Age mean = 50.94, range = 18–98; 48.3% female) were surveyed online twice, once prior to the pandemic (January 31–February 10, 2020) and again early in the outbreak (March 18–29, 2020). A latent profile analysis identified profiles of social contact change across social ties and communication methods. Additional analyses identified predictors of group membership and their association with mental health. Three latent groups were identified: (1) the “majority group” (77%) slightly restricted in‐person contact and had a small increase in phone and text use, (2) the “high technology use group” (13%) restricted in‐person contact and increased the use of all technology‐based methods, and (3) the “isolated group” (10%) decreased in both in‐person and technology‐based contact. Compared to the majority group, the high technology use group reported higher depression and anxiety, whereas the isolated group reported higher loneliness. There were three distinct profiles of how adults in the United States changed their communication patterns with others early in the pandemic that were linked to distinct patterns of mental health. The results have implications for the development and the delivery of mental health treatment in times of social (physical) distancing.
A philosophically neutral semantics for perception sentences
Authors: Iaquinto Samuele , Spolaore Giuseppe 
Published: December 2021

AbstractJaakko Hintikka proposed treating objectual perception sentences, such as “Alice sees Bob,” as de re propositional perception sentences. Esa Saarinen extended Hintikka's idea to eventive perception sentences, such as “Alice sees Bob smile.” These approaches, elegant as they may be, are not philosophically neutral, for they presuppose, controversially, that the content of all perceptual experiences is propositional in nature. The aim of this paper is to propose a formal treatment of objectual and eventive perception sentences that builds on Hintikka's modal approach to propositional attitude ascriptions while avoiding controversial assumptions on the nature of perceptual experiences. Despite being simple and theoretically frugal, our approach is powerful enough to express a variety of interesting philosophical views about propositional, objectual, and eventive perception sentences, thus enabling the study of their inferential relationships.
Ten-year reduction in thoracic injury-related mortality among Israel Defense Forces soldiers
Authors: Chen Jacob , Tsur A M , Nadler R , Beit Ner E , Sorkin A , Radomislensky I , Peleg K , Ben Avi R , Shushan G , Glassberg E , Benov A 
Published: December 2021

IntroductionThis study aims to describe injury patterns, prehospital interventions and mortality rates of combat-related thoracic injuries during the past decade among Israel Defense Forces (IDF) soldiers before and after implementation of the 2012 IDF-Military Corps‘My Brother’s Keeper’plan which included the publication of clinical practice guidelines (CPGs) for thoracic injuries, emphasis on adequate torso protection, introduction of modern life-saving procedures and encouragement of rapid evacuation.MethodsThe IDF prehospital trauma registry was reviewed to identify all patients who sustained thoracic injuries from January 2006 to December 2017. IDF soldiers who were injured, died of wounds or killed in action (KIA) were included. These were cross-referenced with the Israel National Trauma Registry. The periods before and after the plan were compared.Results458 (12.3%) of 3733 IDF soldiers wounded on the battlefield sustained combat-related thoracic injuries. The overall mortality was 44.3% before the CPG and 17.3% after (p<0.001). Most were KIA: 97% (95 of 98) died by 30 June 2012, and 83% (20 of 24) after (p<0.001). Casualties treated with needle thoracostomy before and after CPG were 6.3% and 18.3%, respectively (p=0.002). More tube thoracostomies were performed after June 2012 (16.1% vs 5.4%, p=0.001). Evacuation was faster after June 2012 (119.4 min vs 560.8 min, p<0.001), but the rates of casualties evacuated within 60 min were similar (21.1% vs 25%, p=0.617).ConclusionsAmong military casualties with thoracic injuries, the rate of life-saving interventions increased, evacuation time decreased and mortality dropped following the implementation of My Brother’s Keeper plan.
Do deaths from road traffic injuries follow a classical trimodal pattern in North West Ethiopia? A hospital-based prospective cohort study
Authors: Denu Zewditu Abdissa , Yassin Mensur Osman , Azale Telake , Biks Gashaw Andargie , Gelaye Kassahun Alemu 
Published: December 2021

ObjectiveThe objective of this study was to identify timing distribution and predictors of deaths following road traffic injuries among all age groups at Gondar Comprehensive specialised hospital.DesignA single-centre prospective cohort study.SettingThe study hospital is a tertiary hospital in North West Ethiopia.ParticipantsWe enrolled 454 participants who sustained road traffic injuries in to the current study. All age groups and injury severity were included except those who arrived dead, had no attendant and when the injury time was unknown.Primary and secondary outcome measuresThe primary outcome was time to death measured in hours from injury time up to the 30th day of the injuries. Secondary outcomes were prehospital first aid, length of hospital stay and hospital arrival time. The article has been registered, with a unique identification number of research registry 6556.ResultsA total of 454 victims were followed for 275 534 person hours. There were 80 deaths with an overall incidence of 2.90 deaths per 10 000 person hours of observation (95% CI 2.77 to 3.03). The significant predictors of time to death were being a driver (AHR=2.26; 95% CI 1.09 to 4.65, AR=14.8), accident at interurban roads ((AHR (Adjusted HAzard Ratio=1.98; 95% CI 1.02 to 3.82, AR (Attributable Risk)=21%)), time from injury to hospital arrival (AHR=0.41; 95% CI 0.16 to 0.63; AR=3%), systolic blood pressure on admission of <90 mm Hg (AHR=3.66; 95% CI 2.14 to 6.26; AR=57%), Glasgow Coma Scale of <8 (AHR=7.39; 95% CI 3.0819 to 17.74464; AR=75.7%), head injury with polytrauma (AHR=2.32 (1.12774 4.79; AR=37%) and interaction of distance from hospital with prehospital care.ConclusionThough the maturation of trauma centres in many developed countries has changed the temporal pattern of deaths following any trauma, our study demonstrated that trauma deaths follow the traditional trimodal pattern. That implies that potentially preventable causes of death continued in low-resource countries.
Identifying patients with psychosocial problems in general practice: a scoping review protocol
Authors: Schwenker Rosemarie , Kroeber Eric Sven , Deutsch Tobias , Frese Thomas , Unverzagt Susanne 
Published: December 2021

IntroductionPsychosocial problems (PSPs) are common issues associated with negative health outcomes. Since general practitioners are the first point of contact for any health-related concern, understanding their options to recognise patients with PSPs plays an important role as it is essential for early intervention and can prevent serious conditions. The objective of our scoping review is to map published evidence on the usage of instruments to identify patients with PSPs in general practice.Methods and analysisWe will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist and the Joanna Briggs Institute Reviewer’s Manual on scoping reviews. A systematic search of four electronic databases (Medline (Ovid), Web of Science Core Collection, PsycInfo, Cochrane Library) will be conducted for quantitative and qualitative studies published in English, Spanish, French and German. Main study characteristics as well as information on identification instruments will be extracted and visualised in structured tables to map the available evidence. The protocol has been registered with Open Science Framework,https://osfio/c2m6z.Ethics and disseminationThis study does not require ethical approval as we will not collect personal data. Dissemination will consist of publications, presentations and other knowledge translation activities.
Evaluation of the insertion parameters and complications of the i-gel Plus airway device for maintaining patent airway during planned procedures under general anaesthesia: a protocol for a prospective multicentre cohort study
Authors: Klementova Olga , Bhoday Taranpreet Kaur , Werner Jakub , Lopez Ana M , Donaldson Will , Lichnovsky Erik , Gaszyński Tomasz , Henlin Tomas , Bruthans Jan , Ulrichova Jitka , Lukes Martin , Blaha Jan , Kral Michal , Gomez Lidia , Berge Raquel , Holland Jonathan , McAleavey Francis , Arava Shiva , Merjava Skripecka Lubica , Sobczyk Sebastian , Tyll Tomas , Michalek Pavel 
Published: December 2021

IntroductionSupraglottic airway devices represent a less invasive method of airway management than tracheal intubation during general anaesthesia. Their continued development is focused mainly on improvements in the insertion success rate and minimalisation of perioperative and postoperative complications. The i-gel Plus is a novel, anatomically preshaped supraglottic airway device which achieves a perilaryngeal seal due to a non-inflatable cuff made of a soft thermoplastic elastomer. The purpose of this cohort study is to assess the success rate of the i-gel Plus use during elective procedures under general anaesthesia, its intraoperative performance, and the degree of postoperative complications.Methods and analysisThis is a multicentre, prospective, interventional cohort study. The enrolment will take place in seven centres in four European countries. We plan to enrol 2000 adult patients in total, who are scheduled for elective surgery under general anaesthesia, and with an indication for use of a supraglottic airway device for management of their airway. The study is projected to run over a period of 18 months. The primary outcome of the study is the total success rate of the i-gel Plus insertion in terms of successful ventilation and oxygenation through the device. Secondary outcomes include perioperative parameters, such as insertion time, seal/leak pressures, number of insertion attempts and postoperative adverse events and complications. Postoperative follow-up will be performed at 1 hour, 24 hours in all patients, and for selected patients at 3 and 6 months.Ethics and disseminationThe cohort study has received the following ethical approvals: General University Hospital Prague, University Hospital Olomouc, University Military Hospital Prague, University Hospital Barcelona, University Hospital Lodz, Antrim Area Hospital, Craigavon Area Hospital, Office for Research Ethics Committees Northern Ireland. The results will be published in peer-reviewed journals and presented at relevant anaesthesia conferences.Trial registration numberISRCTN86233693;Pre-results.
Study protocol for a randomised controlled trial on the effect of local analgesia for pain relief after minimal invasive sacroiliac joint fusion: the ARTEMIS study
Authors: Hermans Sem M M , Nellensteijn Jorm M , van Santbrink Henk , Knoef Rob , Reinders Mattheus K , Hoofwijk Daisy M N , Potters Jan W , Movig Kris L L , Curfs Inez , van Hemert Wouter L W 
Published: December 2021

IntroductionChronic lower back pain is a common report in the general population. A dysfunctional sacroiliac joint (SIJ) is estimated to be responsible for one in five patients with lower back pain. Minimally invasive sacroiliac joint fusion (MISJF) is a surgical procedure to treat SIJ dysfunction. During the procedure, the SIJ is stabilised by implants inserted percutaneously under fluoroscopy guidance. Postoperatively, patients often report a lot of pain, which contributes to patients taking high doses of painkillers (opioids for example,) and preventing early mobilisation. In several orthopaedic procedures, intraoperative infiltration of the wound bed results in decreased consumption of analgesics, earlier mobilisation and shorter hospitalisation time. The aim of this study is to investigate the effectiveness of intraoperative SIJ infiltration with analgesia in reducing postoperative pain after MISJF.Methods and analysisWe will perform a two-centre, prospective, double-blind, randomised controlled trial to determine whether SIJ infiltration with 1.5–5 cc bupivacaine 0.50% is superior to 1.5–5 cc placebo (NaCl 0.9%) in reducing postoperative pain in patients after MISJF, and to determine whether bupivacaine significantly reduces opioid use in the direct postoperative period. Patients will be randomised with 1:1 allocation for either bupivacaine (intervention) or placebo SIJ infiltration. Postoperative pain will be measured by the Visual Analogue Scale pain score at entry and exit recovery, 2, 4, 6, 24 and 48 hours postoperatively.Ethics and disseminationThis is the first trial that investigates the effectiveness of intraoperative SIJ infiltration with bupivacaine 0.50% in reducing postoperative pain after MISJF. If intraoperative SIJ infiltration with bupivacaine 0.50% proves to be effective, this might have important clinical implications, such as postoperative analgesics (opioids for example,) consumption, earlier mobilisation and potentially shorter hospitalisation time.Trial registration numberNL9151.
A new and gauge-invariant littlest Higgs model with T-parity
Authors: Illana José Ignacio , Pérez-Poyatos José María 
Published: December 2021

AbstractWe inspect the Littlest Higgs model with T-parity, based on a global symmetry SU(5) spontaneously broken to SO(5), in order to elucidate the pathologies it presents due to the non-trivial interplay between the gauge invariance associated to the heavy modes and the discrete T-parity symmetry. In particular, the usual Yukawa Lagrangian responsible for providing masses to the heavy ‘mirror’ fermions is not gauge invariant. This is because it contains an SO(5) quintuplet of right-handed fermions that transforms nonlinearly under SU(5), hence involving in general all SO(5) generators when a gauge transformation is performed and not only those associated to its gauge subgroup. Part of the solution to this problem consists of completing the right-handed fermion quintuplet with T-odd ‘mirror partners’ and a gauge singlet, what has been previously suggested for other purposes. Furthermore, we find that the singlet must be T-even, the global symmetry group must be enlarged, an additional nonlinear sigma field should be introduced to parametrize the spontaneous symmetry breaking and new extra fermionic degrees of freedom are required to give a mass to all fermions in an economic way while preserving gauge invariance. Finally, we derive the Coleman–Weinberg potential for the Goldstone fields using the background field method.
Explaining Machine Learning Models for Clinical Gait Analysis
Authors: Slijepcevic Djordje , Horst Fabian , Lapuschkin Sebastian , Horsak Brian , Raberger Anna-Maria , Kranzl Andreas , Samek Wojciech , Breiteneder Christian , Schöllhorn Wolfgang Immanuel , Zeppelzauer Matthias 
Published: December 2021

Machine Learning (ML) is increasingly used to support decision-making in the healthcare sector. While ML approaches provide promising results with regard to their classification performance, most share a central limitation, their black-box character. This article investigates the usefulness ofExplainable Artificial Intelligence(XAI) methods to increase transparency in automatedclinical gait classificationbased on time series. For this purpose, predictions of state-of-the-art classification methods are explained with a XAI method called Layer-wise Relevance Propagation (LRP). Our main contribution is an approach that explains class-specific characteristics learned by ML models that are trained for gait classification. We investigate several gait classification tasks and employ different classification methods, i.e., Convolutional Neural Network, Support Vector Machine, and Multi-layer Perceptron. We propose to evaluate the obtained explanations with two complementary approaches: a statistical analysis of the underlying data using Statistical Parametric Mapping and a qualitative evaluation by two clinical experts. A gait dataset comprising ground reaction force measurements from 132 patients with different lower-body gait disorders and 62 healthy controls is utilized. Our experiments show that explanations obtained by LRP exhibit promising statistical properties concerning inter-class discriminativity and are also in line with clinically relevant biomechanical gait characteristics.
Long-Term Survival With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy
Authors: Elliott Perry , Drachman Brian M. , Gottlieb Stephen S. , Hoffman James E. , Hummel Scott L. , Lenihan Daniel J. , Ebede Ben , Gundapaneni Balarama , Li Benjamin , Sultan Marla B. , Shah Sanjiv J. 
Published: December 2021

Background:
Tafamidis is approved in many countries for the treatment of transthyretin amyloid cardiomyopathy. This study reports data on the long-term efficacy of tafamidis from an ongoing long-term extension (LTE) to the pivotal ATTR-ACT (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial).

Methods:
Patients with transthyretin amyloid cardiomyopathy who completed ATTR-ACT could enroll in an LTE, continuing with the same tafamidis dose or, if previously treated with placebo, randomized (2:1) to tafamidis meglumine 80 or 20 mg. All patients in the LTE transitioned to tafamidis free acid 61 mg (bioequivalent to tafamidis meglumine 80 mg) following a protocol amendment. In this interim analysis, all-cause mortality was assessed in patients treated with tafamidis meglumine 80 mg in ATTR-ACT continuing in the LTE, compared with those receiving placebo in ATTR-ACT transitioning to tafamidis in the LTE.

Results:

Median follow-up was 58.5 months in the continuous tafamidis group (n=176) and 57.1 months in the placebo to tafamidis group (n=177). There were 79 (44.9%) deaths with continuous tafamidis and 111 (62.7%) with placebo to tafamidis (hazard ratio, 0.59 [95% CI, 0.44–0.79];
P
<0.001). Mortality was also reduced in the continuous tafamidis (versus placebo to tafamidis) subgroups of: variant transthyretin amyloidosis (0.57 [0.33–0.99];
P
=0.05) and wild-type transthyretin amyloidosis (0.61 [0.43–0.87];
P
=0.006); and baseline New York Heart Association class I and II (0.56 [0.38–0.82];
P
=0.003) and class III (0.65 [0.41–1.01];
P
=0.06).

Conclusions:
In the LTE, patients initially treated with tafamidis in ATTR-ACT had substantially better survival than those first treated with placebo, highlighting the importance of early diagnosis and treatment in transthyretin amyloid cardiomyopathy.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01994889 and NCT02791230.
Cold from Gold: Chinese Miners Face New Realities in Ghana
Authors: Nkrumah Daniel , Bekoe Daniel Norris 
Published: December 2021

China has maintained strong relationships with many African countries, and Ghana is one such country. While the two countries have normally enjoyed good friendly relations, concerns over the involvement of Chinese citizens in small-scale mining in Ghana threaten the cordial relationship between the two countries. There is evidence of a cultural evolution and a gradual shift from a culture of enthusiastic reception of local people to the Chinese in the area of mining to one of cold reception to Chinese interests in mining communities. There is also evidence that this cold reception to Chinese miners is stimulated by non-state actors led by the media and inspires in Ghana a new paradigm of more rational engagement with China at the political level, although challenges still remain.
Diagnostic performance of MRI and endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy: a systematic review of the literature
Authors: Munk Nicolai Egholt , Bondeven Peter , Pedersen Bodil Ginnerup 
Published: December 2021

BackgroundThe diagnostic performance of magnetic resonance imaging (MRI) modalities and/or endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy (nCRT) is unclear.PurposeTo summarize existing evidence on the diagnostic performance of diffusion-weighted MRI, perfusion-weighted MRI, T2-weighted MR tumor regression grade, and/or endoscopy for assessing complete tumor response after nCRT.Material and MethodsMEDLINE and Embase databases were searched. The PRISMA guidelines were followed. Sensitivity, specificity, negative predictive, and positive predictive values were retrieved from included studies.ResultsIn total, 81 studies were eligible for inclusion. Evidence suggests that combined use of MRI and endoscopy tends to improve the diagnostic performance compared to single imaging modality. The positive predictive value of a complete response varies substantially between studies. There is considerable heterogeneity between studies.ConclusionCombined re-staging tends to improve diagnostic performance compared to single imaging modality, but the vast majority of studies fail to offer true clinical value due to the study heterogeneity.