bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Stunting According to WHO Growth Standards and Indonesian Growth Reference Charts: A Descriptive Study from Blega Sub-District
Authors: Hilmy Nafiys , Fatharani Maitsa' 
Published: August 2021

Stunting is one of the remaining health issues in Indonesia and its prevalence was still high in the last decades. There are two types of growth charts that can be used in recording the child's growth: growth standards and growth references. In recent times, the selection of the suitable growth charts has become a subject of discussion in many countries. The objective of this study is to describe the prevalence of stunting according to World Health Organization Child Growth Standards (WHOCGS) and Indonesian National Growth Reference Charts (INGRC) of children under five from the Blega sub-district. The secondary data from 2884 children were collected recapitulation of the 'Bulan Timbang' program in February 2020. Z-score of length/height-for-age was plotted according to WHOCGS and INGRC. The result showed that the prevalence of stunting were lower for the INGRC than WHOCGS (5.83% and 11.17%, with p-value <0.001). There was an advantage and disadvantage when using both two growth charts. Further research is still needed to support the result of this study.
Keywords: Stunting, World Health Organization Child Growth Standards, Indonesian National Growth Reference Charts
The Correlation between Sexual Dysfunction and Marital Relationship among Women with Gynaecological Problems
Authors: Nurhayati Nunung , Ulsiyah Utami Nur , Noor Suci , Marfuah Dewi , Lindayani Linlin 
Published: August 2021

<p>Women with gynaecological problems are at high risk of having sexual dysfunction because the problems could affect the marital relationship and sexual satisfaction. The purpose of this study is to determine the relationship between sexual dysfunction and marital relationships in women with gynaecological problems. This study was conducted using a cross-sectional study. The samples were women with gynaecological problems, aged above 18 years old, married, and able to communicate well. Patients with mental disorders were excluded from this study. Convenience sampling was used to select participants. The marital relationship was measured using a validated instrument, namely, Revised Dyadic Adjustment Scale (RDAS) and the Female Sexual Function Index (FSFI). A total of 82 women with gynaecological problems joined our study. The majority of the respondents experienced sexual dysfunction (90.2%) and more than half of the respondents (52.4%) experienced distress in marital relationships. There was a relationship between sexual dysfunction and marital relationship among women with gynaecological problems (<em>p</em> value &lt; 0.005) and the coefficient correlation was 0.326. Sexual dysfunction may affect marital relationships in women with gynaecological problems. Healthcare professionals need to provide appropriate intervention to women with gynaecological problems as well as facilitate them to express their sexual activity.</p>
Model Development of Implementing Nurse's Role in Improving Patient Safety in Rumah Sakit Umum Deli Medan
Authors: Halawa Afeus , Setiawan Setiawan , Syam Bustami 
Published: August 2021

<div class="Section1"><table border="0" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="600"><p align="center"><strong>ABSTRACT</strong></p><p>Patient safety has become a global issue of concern in health care. Various efforts have been made to improve patient safety in the hospital by involving the health team, one of which is a nurse, a health worker who interacts 24 hours with patients. The role of nurses is a major factor in improving patient safety in the hospital. The purpose of this study was to develop a role model for implementing nurses in improving patient safety at <em>Rumah</em><em> </em><em>Sakit</em><em> </em><em>Umum Deli Medan</em>. This research was a qualitative research with an action research approach involving 15 nurses as participants. Data collection was carried out by means of focus group discussions (FGD), observation, and questionnaires about the role in patient safety. The data obtained were evaluated using content analysis and simple statistics. The results of this study were in the form of a blueprint for the role model of the implementing nurse in improving patient safety, with the outcome of the increasing knowledge of the implementing nurse. The researchers concluded that proper implementation was very important to raise awareness of the importance of preventing incidents of injury to patients.</p><p> </p><p>Keywords: Role, Nurse, Patient Safety</p><p> </p></td></tr></tbody></table></div><strong><br clear="all" /> </strong><p><strong> </strong></p><p> </p><p> </p>
Experimental Study on the Permeability of Quartz Sandstone under Coupled Thermo-Hydromechanical Loading
Authors: Zhang Yu , Yu Tingting , Li Jianwei , Jia Yun , Li Dayong 
Published: August 2021

Abstract
This paper focuses on the influence of coupled thermo-hydromechanical processes on the permeability of quartz sandstone. The permeability has been studied under five different confining pressures, three different temperatures, and three fluid pressures. The experimental results exhibit that the permeability of quartz sandstone decreases with the increase of confining pressure while it increases with temperature and fluid pressure. The identification of permeability under fully coupled thermo-hydromechanical conditions is also studied via the realization of four coupled tests. One observes that the temperature plays a more important role on the permeability with respect to the fluid pressure. Moreover, the influence of fluid pressure on the permeability of studied sandstone has been amplified by the temperature. The obtained experimental results allow us to get a good understanding of the permeability of quartz sandstone in petroleum engineering and can help us to guarantee the long-term structural stability.
Foam Flow in Different Pore Systems—Part 2: The Roles of Pore Attributes on the Limiting Capillary Pressure, Trapping Coefficient, and Relative Permeability of Foamed Gas
Authors: Adebayo Abdulrauf Rasheed 
Published: August 2021

Summary
The limiting capillary pressure of foam (Pc*) and foam trapping in porous media are pore-scale foam properties that affect foam transport in porous media. They are strongly influenced by the characteristics of rock pores and throats. Because of experimental limitations, these foam properties are difficult to measure at core scale. As a result, our understanding of their relationship with different pore characteristics is limited. In this paper, novel coreflood and graphical analysis techniques were used to measure Pc* and the foam-trapping coefficient (FTC) at core scale. FTC is a new parameter synonymous to Land’s (1968) trapping coefficient, which describes foam-trapping behavior across an entire range of saturation as opposed to a single endpoint trapped saturation. The scalability of these two foam properties with permeability and other pore characteristics [average pore size (PS), average throat size (TS), average aspect ratio (AR), coordination number (CN), surface area/volume ratio, and reservoir-quality index (RQI)] were also investigated. Pore characteristics of 12 different rock samples were measured from 3D pore-network models generated from high-resolution X-ray computed-microtomography images. The heterogeneity of the rock samples were quantified by the Dykstra-Parsons index (Dysktra and Parsons 1950), while the RQI and J-function methods were used to classify them according to their storage and flow properties. Each of the measured pore characteristics and their combination [combined pore character (CPC)] were then correlated with Pc* and FTC to understand their respective roles. Furthermore, the data points obtained from the graphical analysis of the coreflood data provided the required input data for a mechanistic foam model for relative permeability of foamed gas (Kovscek and Radke 1994). The estimated relative permeability of foamed gas was then used to study foam mobility in the different pore geometries.
The overall results showed the following:
P c * has strong negative correlations with all pore characteristics except AR, which has a weak positive correlation. P c * has the strongest correlation with RQI, CPC, and permeability; a moderate correlation with CN and TS; and a very weak correlation with PS. Foam trapping has positive correlations with all pore characteristics except AR, which has a negative correlation. Low AR appears to be responsible for significant trapping of foam in high-permeability rocks. Low AR favors more foam trapping, while high AR favors trapping of oil and gas during water imbibition in water-wet rocks. Foam trapping appears to have the dominant control on foam mobility.
FRET-Seq: a High-Throughput FRET-Based Screening Platform to Improve FRET Biosensors in Mammalian Cells
Authors: Liu Longwei , Limsakul Praopim , Meng Xianhui , Huang Yan , Harrison Reed E. S. , Huang Tse-Shun , Shi Yiwen , Yu Yiyan , Charupanit Krit , Zhong Sheng , Lu Shaoying , Zhang Jin , Chien Shu , Sun Jie , Wang Yingxiao 
Published: August 2021

Abstract
Genetically-encoded biosensors based on FRET have been widely used to dynamically monitor the activity of protein tyrosine kinases (PTKs) in living cell with high spatiotemporal resolution. However, the limitation in sensitivity, specificity, and dynamic range of FRET biosensors have hindered their broader applications. Here, we introduced a systematic platform, FRET-Seq, which integrates high-throughput FRET sorting and next-generation sequencing, to identify FRET biosensors with better performance from large-scale libraries directly in mammalian cells.
MED29, A Subunit of the Mediator Complex, Possesses Oncogenic Characteristics in Ovarian Cancer
Authors: Wu Haifang , Chen Ling , Wu Yiguo , Lou Weiming , Nie Penghui , Tang Xiaoli , Fu Fen 
Published: August 2021

Abstract
Background: Somatic copy number alteration (SCNA) usually accompanies the appearance of tumours; one common example is the 19q13.2 region amplification (AMP), mediator complex subunit 29 (MED29) were an amplified effector gene within this region. In this study, the role and molecular mechanism of MED29 in ovarian cancer (OvCa), one of the three major tumours in gynaecology, were discussed.Results: According to the transcriptome and survival data from the TCGA database, 19q13.2 AMP corresponded with a worse prognosis of OvCa patients (P = 0.0253), and individuals with 19q13.2 AMP showed increased levels of MED29 mRNA. From the GSE29450 dataset, we found that the gene expression of MED29 was significantly upregulated in OvCa and overexpression of MED29 in OvCa was related to shorter survival. Additionally, pathway analysis based on RNA-seq data indicated that MED29 could activate the expression of genes involved in cell proliferation. Moreover, knockdown of MED29 obvious inhibited the proliferation, invasion and migration of OVCAR3 and A2780 cells and arrested the cell cycle at the G2/M transition in vitro.Conclusion: MED29 could be used as a potential therapeutic target for OvCa treatment.
Can Internet Use Improve Farmers' Welfare Effect——A Case Study of Chinese Vegetable Growers
Authors: Yan Di , Xu Ge 
Published: August 2021

Abstract
This article uses the data of 797 vegetable growers in Shouguang, Shandong Province, and the endogenous conversion model to investigate the impact of Internet use on household welfare. We select the per-mu vegetable yield, net income, and per capita net income of households as welfare indicators. The results show: ① Internet use can significantly improve the farmers' welfare effect. ②Under counterfactual assumptions, when farmers who use the Internet do not use it, the farmers' vegetable yield per mu, net income and household per capita net income will drop by 10.88%, 13.96% and 9.46%. When farmers who do not use the Internet use it, the farmers' vegetable output, net income and family per capita net income will rise by 13.62%, 16.66% and 11.64%. Internet use has the most excellent effect on the net income of vegetables, followed by the yield per mu, and the net income per household is the lowest. ③ Compared with small-scale farmers, Internet use has a better impact on the welfare of large-scale farmers, which also widens the welfare gap between farmers to a certain extent. Based on this, make suggestions to strengthen information infrastructure, improve information technology training, and adjust support policies promptly.
Silibinin can enhance the osseointegration of titanium rods in ovariectomized rats maintenance treatment with valproic acid
Authors: tao zhoushan 
Published: August 2021

Abstract
The present work was aimed to evaluate the effect of valproic acid(VPA)，Silibinin (SIM)+VPA on Ti rods osseointegration in ovariectomized rats and further investigation of the possible mechanism. The MC3T3-E1 cells were co-cultured with VPA，SIM +VPA and induced to osteogenesis, and the cell viability，mineralization ability were observed by MTT and ALP staining，Alizarin Red staining and Western blotting. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups: group OVX and VPA，SIM +VPA, and all the rats received Ti implants and animals belong to group VPA，SIM +VPA received valproic acid(300 mg/kg/day), valproic acid(300 mg/kg/day) plus SIM (25mg/kg/day) , respectively, treatment until death at 12 weeks. Micro-CT, histology, biomechanical testing, bone metabolism index and Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis were used to observe the therapeutic effect and explore the possible mechanism. Results shown that VPA decreased new bone formation around the surface of titanium rods and push-out force other than group OVX. Histology, Micro-CT and biochemical analysis results showed combined application of systemic VPA showed harmful effects than OVX group on bone formation in osteopenic rats, with the worse effects on CTX-1, P1NP and microarchitecture as well as biomechanical parameters by down-regulated gene expression of Runx2, OCN, Smad1, BMP-2 and OPG, while up-regulated RANKL. However, after SIM treatment, the above indicators were significantly improved. The present study suggests that systemic use of VPA may bring harm to the stability of titanium implants in osteoporosis, SIM can reverse the negative effect of VPA on the osseointegration of titanium rods in ovariectomized rats.
Development of a Social Distancing Monitoring System in Korea: Results of a Modified Delphi Process
Authors: Seo Suin , Han Jin-ok , Shin Sol , Lee Heeyoung 
Published: August 2021

Abstract
Background: Since the COVID-19 pandemic is an ongoing situation in most countries worldwide, a “social distancing” policy as a non-pharmaceutical intervention has been implemented for several months in many countries including Korea. Social distancing policies work in different ways and at different levels. In addition, various forms of surveillance systems have been implemented in different countries. However, there is an almost complete lack of specific surveillance system in Korea to effectively monitor social distancing policy. This study aims to develop a monitoring system for social distancing measures in Korea to evaluate and improve the implemented policy. Methods: A draft monitoring system was developed after reviewing Korea's social distancing measures (central and local government briefings) and checking available data for applications. The modified Delphi process was used to evaluate the draft of the monitoring system. In total, 27 experts participated in the evaluation. The round 1 evaluation includes (1) commenting on the composition of the monitoring fields (open response), (2) monitoring indicators for each monitoring field (10-point Likert scale), and (3) commenting on the source of data used to develop the monitoring system (open response). In the round 2 evaluation, 55 indicators, excepting open responses, were re-evaluated.Results: The response rate for the Delphi survey was 100% in both the first and second rounds. Of the 55 indicators, 14 were excluded according to experts’ open response comments, as these indicators did not satisfy the quantitative criteria. Finally, 41 indicators were included with 12 available data sources. The monitoring system domain was divided into input, process/output, and result.Conclusions: This study is significant in that it is the first in Korea to develop a comprehensive monitoring system for social distancing policy, and is applicable to estimates utilizing data that are immediately available for each indicator. Furthermore, the developed monitoring system could be a reference for other countries that require the development of such systems to monitor social distancing measures.
Biomechanical Modeling of the Pelvic System: Improving the Accuracy of Prostate Lesions Location in MRI–TRUS Fusion
Authors: Qasim Muhammad , Puigjaner Dolors , Herrero Joan , López Josep M. , Garcia–Bennett Josep R. , Olivé Carme , Fortuny Gerard 
Published: August 2021

Abstract
Background: An accurate knowledge of prostate lesions relocation during biopsy is of great importance to prevent mispositioning of the needle and thus reduce the chance of faulty biopsy results (false negatives). Prostate lesions are visible in magnetic resonance images (MRI) but it is difficult for the practitioner to locate them at the time of performing a transrectal ultrasound (TRUS) guided biopsy. In this study, we present a new methodology that predicts both prostate deformation and lesion migration during the biopsy.Methods: A thee-dimensional (3-D) anatomy model of the pelvic region, based on medical images, is constructed. A finite element (FE) simulation of the organs motion and deformation as a result of the pressure exerted by the TRUS probe was carried out using the code_aster open source software. Initial positions of potential prostate lesions prior to biopsy are taken into consideration and the final location of each lesion is targeted in the FE simulation output.Results: Our 3-D FE simulations show that the effect of the pressure exerted by the TRUS probe is twofold as the prostate experiences both a motion (in the absolute frame of reference) and a deformation of its original shape. We targeted the relocation of five small prostate lesions when the TRUS probe exerts a force of 30 N on the rectum inner wall. The distance traveled by these lesions ranged between 5.6 and 13.9 mm. Moreover, we showed that as a result of the deformation of the prostate the resulting lesion migration might be very difficult to predict if the biopsy practitioner has to rely exclusively on a visual comparison of axial or sagittal prostate slices taken from MRI and TRUS images.Conclusions: The preliminary results presented here show that our new methodology can be of great help for improving the prediction of cancerous lesions location when a TRUS guided biopsy is performed. Moreover, the new methodology is completely developed on open source software, which means that its implementation would be affordable even for healthcare providers with small budgets.
Updated Cutoff Values of Basal Serum Calcitonin to Discriminate True Medullary Thyroid Cancer from Other Conditions of Hypercalcitoninemia
Authors: Liu Qianhui , Nie Xin , He Yong , Li Guixing 
Published: August 2021

Abstract
Background

Calcitonin (Ctn) is a tumor marker of medullary thyroid carcinoma (MTC). However, serum Ctn cutoff values for MTC diagnosis are still under discussion. This study aimed to identify the cutoff values of Ctn and explore the relationship between two tumor markers (Ctn and carcinoembryonic antigen (CEA)) and disease burden.
Methods

This was a retrospective study conducted in West China Hospital of Sichuan University. We included 61 MTC patients and 235 non-MTC patients with nonspecific elevation of Ctn (> 9.52 pg/mL for males and > 6.40 pg/mL for females) and collected patients’ demographic information, essential serological indicators, cervical ultrasound and pathological reports.
Results

Unlike MTC, papillary thyroid carcinoma (40.85%), uremia (18.73%), chronic renal disease (10.21%) and inflammation (8.94%) commonly occurred with hypercalcitoninemia. The Ctn cutoff values were 38.24 pg/mL for males and 26.00 pg/mL for females. The Ctn level was found to be positively related to the largest tumor diameter (r = 0.702). Serum Ctn levels were significantly higher in patients with lymph node metastasis than in those without (P < 0.05), but CEA levels did not differ (P > 0.05).
Conclusion

The best Ctn cutoff values for Chinese people to discriminate MTC from other hypercalcitoninemia conditions are 38.24 pg/mL for males and 26.00 pg/mL for females.
Risk Factors for the Morbidity and Prognosis of Lung Metastases in Newly Diagnosed Ovarian Carcinoma: A Large Population-based Study
Authors: Ding Shuning , Guo Kaibo , Wu Linqin , Li Dongxu , Wang Peipei , Sun Leitao , Ruan Shanming , Tao Fangfang 
Published: August 2021

Abstract
Background: To evaluate the risk factors for the morbidity and prognosis of lung metastases (LM) in patients with newly diagnosed ovarian carcinoma (OC). Methods: Based on the Surveillance, Epidemiology, and End Results (SEER) dataset, OC patients from 2010 and 2016 were retrospectively analyzed. Risk factors for the morbidity of LM in OC patients and their survival were assessed by logistic regression analysis and Kaplan-Meier and Gray method, respectively. Cox regression analysis was performed to identify risk factors for the prognosis of OC patients with LM, and their prognostic potentials were further validated by two established nomograms.Results: There are 27,123 eligible OC patients were enrolled in the study, with the morbidity of LM at 5.61% (1,521/27,123). Logistic regression models illustrated that T3 stage [odds ratio (OR)=2.74, 95%CI=2.09-3.66, P<0.01], advanced N stage (OR=1.86, 95%CI=1.62-2.14, P<0.01), and the prevalence of bone metastasis (OR=3.78, 95%CI=2.79-5.11, P<0.01), brain metastasis (OR=4.67, 95%CI=2.50-8.63, P<0.01) and liver metastasis (OR=3.60, 95%CI=3.14-4.12, P<0.01) were all significantly correlated with the morbidity of LM in OC patients. Median survival for OC patients with LM was 11 months (interquartile range, 3 to 25 months). Cox regression analyses illustrated over 80 years of age [hazard ratio (HR)=2.52, 95%CI=2.33-2.72, P<0.01] and positive expression of cancer antigen 125 (CA-125, HR=1.63, 95%CI=1.47-1.82, P<0.01) were significantly correlated with the high mortality of LM, while chemotherapy (HR=0.62, 95%CI=0.59-0.65, P<0.01) was significantly correlated with the low mortality. Two nomograms were established to examine the concordance index (C-index), calibration curves, the area under the curve (AUC), decision curve analyses (DCAs) and clinical impact curves (CICs), which validated the prognostic potentials of identified risk factors in OC patients with LM. Conclusion: The population-based cohort study provides references for guiding clinical screening and individualized treatment of OC patients with LM.