bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Granulomatous Hypersensitivity Reactions to a Dermal Filler Precipitated by PD-1 Checkpoint Inhibitor Therapy
Authors: Dhaliwal Parneet , Ibad Sidra , Losak Diana , Cockerell Clay 
Published: January 2021

Injection of filler material has become routine in dermatology in improving the appearance of rhytides and increasing skin volume associated with aging. While the vast majority of injections are accomplished without complications, foreign body reactions may develop in a certain percentage of individuals. We recently encountered a 65-year-old woman with recurrent malignant melanoma who presented with marked thickening along the sides of her face for approximately 2 months. She recently received nivolumab infusions for recurrent malignant melanoma and noted that symptoms worsened after each infusion. She reported having had cosmetic procedures done three years prior, one of which was an injection of a long-lasting dermal filler, polymethylmethacrylate microsphere enhanced bovine collagen (Bellafill). A biopsy of two areas revealed nodular infiltrates of histiocytes with small round lobules recognizable as polymethylmethacrylate microspheres. Based on clinical and histopathologic findings, a diagnosis of granulomatous dermatitis filler reaction was rendered. Nivolumab is a PD-1 checkpoint inhibitor that disrupts T-cell inhibitory pathways leading to increased immune activation. In this case, the immune activation triggered a florid granulomatous reaction to the filler the patient had been injected with 3 years previously. We present this case as the second report of this phenomenon and the first in the dermatologic literature. This is a newly recognized side effect of PD-1 checkpoint immunotherapy and patients who are about to initiate such therapy who have had filler injections should be warned about this potential complication.
Development and validation of LC-MS/MS method for the simultaneous estimation of tenofovir disoproxil fumarate and pioglitazone HCL in human plasma
Authors: Pagidi Rajagopaludu  , Nimmakayala Saritha  , Devanna N  , Srinivas M  
Published: January 2021

For the simultaneous detection of tenofovir and pioglitazone in a human plasma LC-MS/MS technique was utilized. API-4000 mass spectrometer was used. It should be operated in positive ion mode and contains ion source of turbo spray. Inverted C18 column was used which produces good resolution and symmetrical peaks. Metoprolol is used as internal standard. It requires acidic PH for elution but Tenofovir disoproxil fumarate and Pioglitazone requires neutral PH after extraction which is equity diluted with H2O for supernate. Finally, it provides good resolution and elution. By using Acetonitrile 100mg of Tenofovir Disoproxil fumarate and Pioglitazone HCL were dissolved and the final volume is made with H2O and Acetonitrile in 1:1 ratio to give 1mg/ml. standard stock solution are stored at -2to ± 20 C till analysis is completed. The guidelines were provided by the FDA to fulfill the essentials requires for the technique. To regulate the concentration the procedure starts with standard curve which is built form the quantitative analysis standard ranges form 1-1000ng/mL. To determine the stability freeze-thaw technique were used. To determine the stability the analyte is kept at room temperature for 24 hours. The correlation coefficients for all calibration curves were more than 0.99.
4-Anilino Quinazoline Derivatives: Molecular Docking and Evaluation of In vitro Cytotoxic Activity
Authors: Hemalatha K  , Sujatha K  , Panneerselvam P  , Girija K  
Published: January 2021

A novel scaffold of 4-anilino quinazoline derivatives was designed on the basis of known inhibitor of quinazoline based drugs. The designed derivatives were synthesized using optimized reaction condition. Their structures were confirmed by FT-IR, 1H-NMR, 13C-NMR and Mass spectral data. The structures of synthesized compounds were subjected to in silico molecular docking using AutoDock software against the target Poly (ADP-ribose) polymerase-1 (PARP-1) enzyme. The compounds were evaluated for their in vitro cytotoxic activity against Daltons Lymphocyte Ascites (DLA) Cell lines. Molecular docking study of the newly synthesized compounds showed good binding mode in the active site of PARP-1. The docking results were compared with the standard drug Doxorubicin. Doxorubicin showed binding energy of -8.94 kcal/mol and formed one hydrogen bond with Asn767 with a distance of 1.98 Å. Compound SMOQ2 showed the least binding energy, i.e., 11.87kcal/mol and formed one hydrogen bond with Arg 878 with a distance of 1.895.A° Compound DMUQ5 showed binding energy of -11.42 kcal/mol and produced two hydrogen bonds with Arg 878 and Asn 767. Among the synthesized compounds, compounds SMOQ2 and DMUQ5 showed significant binding affinity compared to the standard drug Doxorubicin. The in vitro cytotoxic evaluation indicated that compounds SMOQ2 and DMUQ5 showed significant cytotoxic activity against Daltons Lymphoma Ascites cell line.
Implementasi Kebijakan Kepala Sekolah Dalam Meningkatkan Kinerja Guru di SMA Negeri 4 Kabupaten Bantaeng
Authors: Afdal Muhammad , Amin Sulvahrul 
Published: January 2021

Penelitian ini mengkaji tentang (1). Bagaimana Implementasi Kebijakan kepala sekolah dalam meningkatkan kinerja guru di SMAN 4 Bantaeng Kabupaten Bantaeng (2) Bagaimana langkah-langkah kebijakan kepala sekolah dalam meningkatkan kinerja guru di SMAN 4 Bantaeng Kabupaten Bantaeng. Jenis penelitian ini adalah penelitian Deskriftif kualitatif, dengan Lokasi Penelitian berada di SMAN 4 Bantaeng, kelurahan Pallantikang kecamatan Bantaeng Kabupaten Bantaeng, Penentuan informan pada penelitian ini dilakukan dengan teknik purposive sampling, dimana pemilihan dilakukan secara sengaja berdasarkan kriteria yang telah ditentukan dan berdasarakan tujuan penelitian. Metode data adalah dengan observasi, wawancara, dokumentasi. Metode analisis data menggunakan empat tahap yaitu, data, reduksi data, penyajian data dan penarikan / pengungkit. Hasil penelitian Pelaksanaan kebijakan kepala sekolah dalam meningkatkan kinerja guru di SMAN 4 Bantaeng. yaitu : 1) Mengadakan pembinaan profesional. 2) Mengadakan Rapat Guru (3). Meningkatkan kedisiplinan guru. Langkah-langkah yang di ambil kepala sekolah adalah: (1) rapat awal tahun ajaran para guru, (2) memfasilitasi guru untuk lanjut studi (3) membuat surat keputusan (SK) dan (4) rapat kordinator masing-masing bidang. (5) Pembimbingan bersifat membimbing.
Pengaruh Ketersediaan Sarana Pendidikan Terhadap Angka Partisipasi Kasar (APK) dI Kota Cilegon
Authors: Pudyastuti Hesti , Mulyaningsih Euis 
Published: January 2021

Penelitian ini bertujuan untuk mengetahui Persentase ketersediaan sarana pendidikan di Kota Cilegon, serta pengaruhnya terhadap Angka Partisipasi Kasar (APK). Metode penelitian dilakukan dengan menggunakan pendekatan kuantitatif, dengan teknik analisis menggunakan analisis regresi linear sederhana. Hasil penelitian yang diperoleh menunjukkan bahwa ketersediaan sarana pendidikan dan APK jenjang pendidikan TK di Kota Cilegon memiliki pengaruh yang moderat, dengan nilai koefisien regresi R2 sebesar 0,482, ketersediaan sarana pendidikan terhadap APK jenjang pendidikan SD di Kota Cilegon memiliki pengaruh yang signifikan, dengan nilai koefisien regresi R2 sebesar 0,854 sedangkan ketersediaan sarana pendidikan terhadap APK jenjang pendidikan SMP di Kota Cilegon tidak memiliki hubungan yang signifikan, dengan nilai koefisien regresi R2 sebesar 0,124.
Mammographic density and its association with molecular subtype of breast cancer.
Authors: Jabeen Naila , Rasheed Binish , Muhammad Imran  , Zaheeruddin Zoobia , Rahim Anila 
Published: January 2021

Background: Breast cancer is the leading cause of death in women globally. The present study aimed to determine the prevalence of different mammographic density of breast parenchyma along with the association with the molecular subtype of breast cancer.
Methodology: The present cross-sectional study was conducted among breast cancer females age 40 and above. The study participants' demographic and clinical data, such as age, sex, menstrual status, gravida, parity, and lactation, were collected using a standard questionnaire. The anthropometric parameters were taken by using the standard techniques. Breast physical examination, mammography, and ultrasound were done. The ultrasound did the breast tumor biopsy -guided techniques and histopathology, and immunohistochemistry was used to identify the molecular subtype of breast cancer. The univariate and multivariate statistic was performed on SPSS version 20.0.
Results: Most of the patients<50 years were human epidermal growth factor receptor (HER2), estrogen receptor (ER), progesterone receptor (PR) positive, and are overweight too. Similar findings were noted among lactating and multigravida patients. The Grade I tumor and dense breast patients were 100% with HER2 negative and ER, PR positive. Most heterogeneous dense and fibroglandular containing breast patients were ER, PR positive. There is a significant correlation between BMI, microcalcification, and HER2 positive. Most of the triple Negative and Luminal-B were heterogeneous dense.
Conclusion: In conclusion, a significant association between the mammographic density parameters and molecular breast cancer subtype, particularly Luminal-A and luminal B, was seen. The ER, PR, and HER-2 have a positive correlation with the physical radiographical and mammodensity parameters.
Frequency of Myofascial Trigger Point in upper trapezius muscle and its associating factors among Physical therapist in Karachi, Pakistan: A cross-sectional survey.
Authors: Latif Amber , Iqbal Siddique Faiza 
Published: January 2021

Background: Myofascial Pain Syndrome (MPS) is the most familiar painful musculoskeletal condition often caused by Myofascial Trigger Point (MTrP). The study objective was to determine the frequency of MTrP in the upper trapezius muscle and investigate its associating factors among physical therapists.
Methodology: A multi-center cross-sectional study was conducted over 258 male and female physical therapists between 20 to 45 years of age with at least 4 working hours/day. The participants filled a self-structured questionnaire, and bilateral upper trapezius MTrP was identified through the investigator's physical assessment. SPSS version 22.0 was used for statistical analysis. Frequencies and percentages were calculated for all categorical variables. Pearson chi-square test was used to compare the association of MTrP with age group, gender, and workplace. A p-value < 0.05 was considered significant.
Results: Out of 258 samples, 70.5% (n=182) were found to have MTrP in the upper trapezius muscle. Within our group, the overall frequency of latent MTrP, i.e. 71.4%, was higher than active MTrP. Poor ergonomics of the workplace, lack of maintaining ideal posture, sleep deprivation, and emotional/psychological stress were the most rated associated factors.
Conclusion: Our study provides preliminary evidence suggesting a high-frequency rate of MTrP in the upper trapezius muscle. This study also suggested a few associated factors which are the cause of developing MTrP. These factors may be useful for developing guidelines for the risk factors and intervention of upper trapezius pain.
ANALISIS TEBAL PERKERASAN RUNWAY DI BANDARA INTERNASIONAL LOMBOK AKIBAT PERKEMBANGAN PROGRAM KAWASAN EKONOMI KHUSUS
Authors: Octavia Nuralifa Dea , Sideman I A O Suwati , Suteja I Wayan 
Published: January 2021

Dengan label daerah wisata menyebabkan peningkatan penerbangan melalui Bandara Internasional Lombok (BIL). Peningkatan ini diprediksi akan semakin meningkat dengan program pemerintah Kawasan Ekonomi Khusus (KEK) Mandalika. Potensi peningkatan ini tentu memberikan dampak pada peningkatan jumlah pergerakan pesawat pada sisi land side khususnya runway. Penelitian ini menggunakan metode FAA secara manual dan membandingkan dengan software FAARFIELD. Tujuan Penelitian ini ialah untuk mengevaluasi tebal perkerasan runway yang ada saat ini dengan tebal perkerasan runway dengan adanya program Kawasan Ekonomi Khusus (KEK) Mandalika pada tahun 2024. Tebal perkerasan runway dengan program KEK Mandalika menggunakan pesawat rencana B739 untuk tahun 2024 adalah sebesar 4 inci untuk lapisan surface, 11.5 inci untuk lapisan base course, dan sebesar 33.5 inci untuk lapisan subbase course. Sedangkan tahun 2038 adalah sebesar 4 inci untuk lapisan surface, 11.9 inci untuk lapisan base course, dan sebesar 34.1 inci untuk lapisan subbase course. Sedangkan dengan menggunakan software adalah sebesar 5 inci untuk lapisan surface, 5 inci untuk lapisan base course, dan sebesar 29.67 inci untuk lapisan subbase course.
Efektivitas Vertical Screw Sebagai Feeder Mangkuk Kotor Pada Mesin Pencuci Mangkuk Ototmatis
Authors: Edilla Edilla , Hendriko Hendriko , Suherman Daud 
Published: January 2021

The bowl feeder is a tool feeder for the process of separating the bowls one by one from the stack arranged vertically and then the bowl will cross the conveyor. Some industries have created screw and pneumatic methods for feeding plastic bowl. However, the existing type of bowl beside plastics there are also ceramics. Ceramic bowl are widely used for culinary. In this final project a bowl feeder device has been made where the process is by placing a dirty bowl in the container so that the bowl will pass one by one to 4 screws which are driven by a dc torque motor which functions for the separation process from the stack. Next, after the bowl reaches the conveyor, it will cross to get to the washing process which is driven by a dc torque motor. The feeder speed can be adjusted using pulse width modulation so it can have variations of speed in the feeder bowl process to get to the washing process. This feeder is able to feed 1411,7 bowl per hour using combination speed of 80 rpm screw motor and 135 rpm conveyor motor.
Adiwiyata Program for Students in the Study of Psychology of Learning and Ecological Counseling Guidance
Authors: Azizah Nur , Nugroho Adhitya Ridwan Budhi Prasetyo 
Published: January 2021

<p style="text-align: justify;">Researchers have conducted studies on the planning, implementation, management and evaluation of the <em>Adiwiyata </em>program in the context of school activities. However, a specific analysis has not been identified in the field of Learning Psychology and Environmental Counseling. The aim of this study is therefore to analyze the <em>Adiwiyata</em> program in the study of Learning Psychology and Ecological Guidance. This literature study was conducted by analyzing the primary sources of the Regulation of the Minister of the Environment of the Republic of Indonesia No. 05 of 2013 on the Guidelines for the Implementation of the <em>Adiwiyata</em> Program and No. P.52/Menlhk/Setjen/Kum.1/9/2019 on the Movement of Environmental Care and Culture in Schools (PBLHS Movement). The results showed that the psychology of learning of the <em>Adiwiyata</em> programme could be integrated into the learning process as well as educational facilities for students using the school environment by considering the psychological development of the students. In the meantime, the <em>Adiwiyata</em> program in the study of ecological counseling guidance can be internalized in creating programs or applied in guidance and counseling services for students to solve the problems and to form students' self-awareness and environmental awareness.</p><p style="text-align: justify;"> </p><p style="text-align: justify;"><em>Kajian</em> <em>penerapan</em> <em>program Adiwiyata mulai dari perencanaan, pelaksanaan, pengelolaan, serta evaluasi maupun penerapan dalam kegiatan di sekolah telah banyak dilakukan. Namun belum ditemukan analisis spesifik dalam kajian psikologi belajar dan bimbingan konseling ekologi. Oleh karena itu, penelitian ini bertujuan menganalisis program Adiwiyata bagi siswa dalam kajian psikologi belajar dan bimbingan konseling ekologi. Metode yang digunakan adalah studi kepustakaan dengan menganalisis sumber primer dari Peraturan Menteri Lingkungan Hidup Republik Indonesia Nomor 05 Tahun 2013 Tentang Pedoman Pelaksanaan Program Adiwiyata dan Nomor P.52/Menlhk/Setjen/Kum.1/9/2019 Tentang Gerakan Peduli dan Berbudaya Lingkungan Hidup di Sekolah (Gerakan PBLHS). Hasil penelitian menunjukkan program Adiwiyata berdasarkan kajian psikologi belajar dapat diintegrasikan dalam proses belajar mengajar maupun sarana edukasi siswa melalui pemanfaatan lingkungan sekolah dengan mempertimbangkan perkembangan psikologis siswa. Sedangkan Program Adiwiyata dalam kajian bimbingan konseling ekologi bisa diinternalisasi dalam pembuatan program maupun diaplikasikan dalam layanan bimbingan dan konseling bagi siswa untuk mendapatkan solusi atas masalahnya maupun membentuk kesadaran diri siswa maupun kesadaran pada lingkungan</em>.</p>
ROLE OF KYNURENINE PATHWAY METABOLITES IN DEPRESSION-A REVIEW
Authors: Soni Priyadarshini , Singh Lubhan , Singh Prabhat , Kumar Sokindra 
Published: January 2021

Today most common psychiatric problem across the world is depression and stress is main source of ailment. According to World health organization, it will be the main cause of morbidity by 2020 in the world. Depression can critically affects the quality of life as it is characterized by many symptoms like unhappy feeling, lack of interest and pleasure, down energy, inadequacy, regret feeling, slow-down of thoughts or reduction in physical movement, speech can affects, altered appetite or sleep, sad, and increase the risk of suicide. Human body is inadequate to produce tryptophan which is a crucial amino acid; therefore it must be required from diet. After absorption, L-tryptophan crosses the BBB (Blood brain barrier) by non-specific L-type amino acid transporter and act as precursor to various metabolic pathways in central nervous system (CNS). Kynurenine is an important pathway that is associated with tryptophan (TRP) metabolism, where it develops a lot of metabolites such as 3-hydroxykynurenine (3HK), anthranilic acid (AA), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA) and quinolinic acid (QUIN) known as kynurenines. It is already reported previously that disturbance in neuroprotective and neurotoxic metabolites leads to many psychiatric disorders. This review summarizes the role of kynurenine pathway metabolites in depression.
TOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS
Authors: Pai Aruna , Rao Jvln Seshagiri , Rajendra Madhu J , Jain Ashish S 
Published: January 2021

Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream in ultraviolet –B-induced psoriasis in rats. Materials &Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol, methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content was determined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of the optimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm with UV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined. Results and Discussion: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) content was found to be significant for water extract.The reducing ability of water extract was always higher than methanol extract at all the concentrations. Conclusion: We concluded that cream containing 0.1% water extract of Terminalia chebula seeds possess antioxidant activity along with potent antipsoriatic activity. Further, application of Terminalia chebula cream resulted in decrease in relative epidermal thickness of animal skin as well as other histopathological features. The present investigation aims at the development of potent phytomedicine for treatment of psoriasis from the Terminalia chebula plant.
Fachhochschulbibliotheken unter COVID-19 – eine Bestandsaufnahme
Authors: Torggler Andrea , Villányi Márton 
Published: January 2021

Die COVID-19 Pandemie hatte im Laufe des letzten Jahres starke Auswirkungen auf die Organisation und Bereitstellung von Services in – vermutlich – sämtlichen Bibliotheken weltweit. Wie haben die Bibliotheken an Fachhochschulen in Österreich diese Krise gemeistert? Anhand einer Umfrage wurden die Leiter*innen der Fachhochschulbibliotheken zu den Maßnahmen ihrer Einrichtungen in Bereichen wie Veränderung der Öffnungszeiten, Zusatzservices, Personal- und Budgetentwicklung u. v. m. befragt. Auf Situationen und Entscheidungen musste oft spontan reagiert werden, in diesem Artikel wird versucht eine halbjährliche Zwischenbilanz zu ziehen.
Potensi Kompos Tandan Kosong Kelapa Sawit terhadap Ketersediaan Fosfor Podsolik Merah Kuning dan Serapannya oleh Bibit Kelapa Sawit (Elaeis Guineensis Jacq.)
Authors: Putri Ulinnuha Difana , Peniwiratri Lelanti , Widodo R. Agus 
Published: January 2021

Penelitian ini bertujuan untuk mengetahui pengaruh kompos TKKS berbeda takaran yang diberi NPK terhadap ketersediaan P Podsolik Merah Kuning dan serapannya oleh bibit kelapa sawit. Penelitian dilakukan di Instalasi Penelitian Tanah, Laladon, Bogor. Penelitian merupakan percobaan pot yang disusun dalam Rancangan Acak Kelompok (RAK) terdiri dari 7 perlakuan dengan 6 ulangan. Perlakuan tersebut terdiri dari Tanpa Perlakuan, NPK Standar, ¾ NPK, ¾ NPK +½ TKKS, ¾ NPK+ ¾ TKKS, ¾ NPK+1 TKKS, ¾ NPK+1 ½ TKKS. Untuk mengetahui pengaruh perlakuan terhadap parameter penelitian dilakukan analisis sidik ragam (ANOVA). Beda rerata antar perlakuan terhadap parameter hasil dilakukan uji beda nyata Duncan Multiple Range Test (DMRT) 5%. Hasil penelitian menunjukkan bahwa pemberian pupuk kompos TKKS berbeda takaran yang diberi NPK berpengaruh nyata meningkatkan P tersedia Podsolik Merah Kuning dan serapan P oleh bibit kelapa sawit. Perlakuan ¾ NPK + ½ TKKS memberikan hasil terbaik terhadap ketersediaan P Podsolik Merah Kuning dan serapannya oleh bibit kelapa sawit.
ANALISIS KESESUAIAN LAHAN TANAMAN SIRSAK, SRIKAYA DAN LENGKENG DI DESA HARGOMULYO, GEDANGSARI, GUNUNGKIDUL
Authors: Meilinda Vina Elviana , Kundarto Muhammad , Santoso AZ. Purwono Budi 
Published: January 2021

Kecamatan Gedangsari direncanakan sebagai daerah penghasil tanaman buah yang berada di Desa Hargomulyo. Penanaman tanaman buah di Desa Hargomulyo merupakan salah satu cara untuk memanfaatkan lahan kering. Tanaman yang akan dibudidayakan yaitu tanaman sirsak, srikaya dan lengkeng di tiga dusun yaitu Dusun Suruh, Jatibungkus dan Mangli. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik lahan dan menganalisis kesesuaian lahan tanaman sirsak, srikaya dan lengkeng di Desa Hargomulyo. Penelitian menggunakan metode survey untuk mengetahui kondisi wilayah, metode purposive sampling untuk penentuan titik sampel berdasarkan Peta Sistem Lahan yang dibuat dengan overlay peta tataguna lahan, peta jenis tanah dan peta kemiringan lereng. Analisis kesesuaian lahan dilakukan dengan metode pembandingan (matching) karakteristik lahan dengan kriteria kesesuaian lahan. Parameter penelitian yang digunakan yaitu temperatur udara, curah hujan, kondisi drainase, tekstur tanah, bahan kasar, kedalaman tanah, KPK tanah, kejenuhan basa, pH H2O, C-Organik, N-Total, P tersedia, K tersedia, kemiringan lereng, bahaya erosi, batuan di permukaan dan singkapan batuan. Hasil penilaian kelas kesesuaian lahan pada tanaman sirsak, srikaya dan lengkeng yaitu kelas S3(lp,rc,eh,oa) 2,0 ha, S3(rc,eh,oa) 2,5 ha, S3(eh,oa,na) 9,9 ha, S3(rc,eh) 8,9 ha, S3(rc) 70,6 ha, S3(eh) 4,4 ha, N(lp,rc,eh) 12,2 ha, N(lp,rc) 45,1 ha, N(rc,eh) 11,6 ha, N(rc) 22,7 ha dan N(eh) 10,6 ha,