bluuebunny/crossref_metadata_2025_split huggingface dataset:
“We know about schistosomiasis but we know nothing about FGS”: A qualitative assessment of knowledge gaps about female genital schistosomiasis among communities living in Schistosoma haematobium endemic districts of Zanzibar and Northwestern Tanzania
Authors: Mazigo Humphrey D. , Samson Anna , Lambert Valencia J. , Kosia Agnes L. , Ngoma Deogratias D. , Murphy Rachel , Matungwa Dunstan J. 
Published: September 2021

Background
Schistosoma haematobium causes urogenital schistosomiasis and is widely distributed in Tanzania. In girls and women, the parasite can cause Female Genital Schistosomiasis (FGS), a gynecological manifestation of schistosomiasis that is highly neglected and overlooked by public health professionals and policy makers. This study explored community members’ knowledge, attitudes and perceptions (KAP) on and health seeking behavior for FGS.

Methods/Principal findings
Using qualitative research methods—including 40 Focus Group Discussions (FGDs) and 37 Key Informant Interviews (KIIs)—we collected data from 414 participants (Males n = 204 [49.3%] and Females n = 210 [50.7%]). The study engaged 153 participants from Zanzibar and 261 participants from northwestern Tanzania and was conducted in twelve (12) purposively selected districts (7 districts in Zanzibar and 5 districts in northwestern Tanzania). Most participants were aware of urogenital schistosomiasis. Children were reported as the most affected group and blood in urine was noted as a common symptom especially in boys. Adults were also noted as a risk group due to their involvement in activities like paddy farming that expose them to infection. Most participants lacked knowledge of FGS and acknowledged having no knowledge that urogenital schistosomiasis can affect the female reproductive system. A number of misconceptions on the symptoms of FGS and how it is transmitted were noted. Adolescent girls and women presenting with FGS related symptoms were reported to be stigmatized, perceived as having a sexually transmitted infection (STI), and sometimes labeled as “prostitutes”. Health seeking behavior for FGS included a combination of traditional medicine, self-treatment and modern medicine.

Conclusion/Significance
Community members living in two very different areas of Tanzania exhibited major, similar gaps in knowledge about FGS. Our data illustrate a critical need for the national control program to integrate public health education about FGS during the implementation of school- and community-based mass drug administration (MDA) programs and the improvement of water, sanitation and hygiene (WASH) facilities.
Indifferent, ambiguous, or proactive? Young men’s discourses on health service utilization for Chlamydia trachomatis detection in Stockholm, Sweden: A qualitative study
Authors: Larsson Frida M. , Nielsen Anna , Briones-Vozmediano Erica , Stjärnfeldt Johanna , Salazar Mariano 
Published: September 2021

Introduction
Chlamydia trachomatis (C. trachomatis) infection is the most commonly reported sexually transmitted infection in Sweden and globally. C. trachomatis is often asymptomatic and if left untreated, could cause severe reproductive health issues. In Sweden, men test for C. trachomatis to a lesser extent than women.

Aim
To explore factors facilitating and constraining Swedish young men’s health care utilization for C. trachomatis detection and treatment.

Method
A qualitative situational analysis study including data from 18 semi-structured interviews with men (21–30 years). Data collection took place in Stockholm County during 2018. A situational map was constructed to articulate the positions taken in the data within two continuums of variation representing men’s risk perception and strategies to test for C. trachomatis.

Results
Based on the informants’ risk perception, strategies adopted to test and the role of social support, three different discourses and behaviours towards C. trachomatis testing were identified ranging from a) being indifferent about C. trachomatis -not testing, b) being ambivalent towards testing, to c) being proactive and testing regularly to assure disease free status. Several factors influenced young men’s health care utilization for C. trachomatis detection, where the role of health services and the social support emerged as important factors to facilitate C. trachomatis testing for young men. In addition, endorsing traditional masculinity domains such as leaning on self-reliance, beliefs on invulnerability and framing men as more carefree with their sexual health than women delayed or hindered testing.

Conclusion
Testing must be promoted among those young men with indifferent or ambivalent discourses. Health systems aiming to increase testing among those at risk should take into consideration the positive role that young men’s social support have, especially the level of social support coming from their peers. Additionally, endorsement of traditional masculinity values may delay or hinder testing.
Implementation of vascular surgery teleconsultation during the COVID-19 pandemic: Insights from the outpatient vascular clinics in a tertiary care hospital in Qatar
Authors: Al-Thani Hassan , Mekkodathil Ahammed , Hussain Ahmed , Sharaf Ahmed , Sadek Ahmed , Aldakhl-Allah Anas , Awad Ahmed , Al-Abdullah Nassar , Zitoun Ahmad , Paul Jini , Pillai Pushpalatha , John Sara , El-Menyar Ayman 
Published: September 2021

Background
The COVID-19 pandemic has sparked a surge in the use of virtual communication tools for delivering clinical services for many non-urgent medical needs allowing telehealth or telemedicine, to become an almost inevitable part of the patient care. However, most of patients with vascular disease may require face-to-face interaction and are at risk of worse outcomes if not managed in timely manner.

Objective
We aimed to describe the utilization of telemedicine services in the outpatient vascular surgery clinics in a tertiary hospital.

Methods
A retrospective analysis of data on all vascular outpatient encounters during 2019 and 2020 was conducted and compared to reflect the pattern of practice prior to and during the COVID-19 pandemic.

Results
The study showed that 61% of the total patient encounters in 2020 were reported through teleconsultation. Females were the majority of patients who sought the virtual vascular care. Consultations for the new cases decreased from 29% to 26% whereas, the follow-up cases increased from 71% to 74% in 2020 (p = 0.001). The number of procedures performed in the vascular outpatient clinics decreased by 46% in 2020 when compared to 2019. This decrease in procedures was more evident in the duration from February 2020 to April 2020 in which the procedures decreased by 97%. The proportion of procedures represented 22.6% of the total encounters in 2019 and 10.5% of the encounters during 2020, (p = 0.001).

Conclusions
Teleconsultation, along with supporting practice guidelines, can be used to maximize the efficiency of care in vascular surgery patients during the pandemic and beyond. Adoption of the ‘hybrid care’ which combines both virtual and in-person services as an ongoing practice requires evidence obtained through audits and studies on patients and healthcare providers levels. It is essential to establish a clear practice that ensures patient’s needs.
It ain’t what you do, it’s the way that you do it: The pitfalls of using routine data to measure early infant HIV diagnosis in HIV-exposed infants
Authors: Chappell Elizabeth , Thorne Claire , Collins Intira Jeannie , Baisley Kathy , Yapa H. Manisha , Gareta Dickman , Bärnighausen Till , Herbst Kobus , Judd Ali 
Published: September 2021

Background
Early infant HIV diagnosis (EID) is critical to ensuring timely diagnosis of HIV-exposed infants, and treatment in those found to be infected. However estimates of coverage vary considerably, depending on data sources used. We used 4 methods to estimate coverage among a historical cohort of HIV-exposed infants in rural South Africa, between 2010–2016.

Methods
We estimated the proportion of infants ever tested (methods 1–3) and tested by 7 weeks of age (1–4) as follows: (1) infants born to women identified as HIV-positive in demographic surveillance were linked to those with ≥1 EID result in routine laboratory surveillance; (2) the number of infants with ≥1 EID result in laboratory surveillance divided by the estimated number of HIV-exposed infants, calculated as total live births multiplied by antenatal HIV seroprevalence; (3) the number of infants with ≥1 EID result in routine laboratory surveillance, divided by the number of HIV-exposed infants as estimated by the district health service; (4) from documentation in infants’ Road-to-Health-booklets.

Results
The proportion ever tested was 43%, 88% and 138% for methods 1–3, and by 7 weeks of age was 25%, 49%, 86% and 46% for methods 1–4 respectively.

Conclusions
The four methods, applied to a range of routine data sources, resulted in estimates varying considerably, and the true coverage of EID remains unclear. Our findings highlight the importance of developing unique patient identifiers, improving training of healthcare providers using reporting systems, and ensuring the accuracy of healthcare records, to ensure the best possible health outcomes for HIV-exposed infants.
Cross-cultural validation of the decisional balance scale in exercise across countries
Authors: Kueh Yee Cheng , Sabo Abdulwali , Kim Youngho , Kuan Garry 
Published: September 2021

BackgroundThis study examined the psychometric properties of the Korean and Malay version of the decisional balance (DB) for exercise (i.e. perceived benefits and perceived barriers) using a cross-sectional design. Also, this study assessed the measurement and structural invariance of the DB scale across countries.MethodsA cross sectional study was conducted in Malaysia and Korea. The study sample consisted of 574 Korean participants and 562 Malaysian participants. The mean age of the participants was 19.8 (SD = 1.29) for the Korean sample and 19.8 (SD = 1.22) for the Malaysian sample. Participants were invited to complete the DB scale with the 10-item and two factors (i.e., perceived benefit and perceived barriers). Confirmatory factor analysis (CFA) and invariance test were conducted on the data by using Mplus 8.3.ResultsThe CFA results based on the hypothesised measurement model of two factors and ten items showed sufficient construct validity after adding residual covariance between items within the same factor: CFI = 0.979, TLI = 0.970, SRMR = 0.036, RMSEA = 0.036 for the Korea sample, and CFI = 0.964, TLI = 0.949, SRMR = 0.055, RMSEA = 0.066 for the Malay sample. For the Korea sample, the construct reliability was 0.62 and 0.74 for perceived benefits and perceived barriers respectively. For the Malay sample, the construct reliability was 0.75 and 0.77 for perceived benefits and perceived barriers respectively. The findings presented evidence for measurement and structural invariance of the DB scale for the Korea and Malaysia samples.ConclusionThe DB scale was a valid and reliable measure for assessing exercise behaviour and for making comparisons between Korean and Malaysian samples.
Having a latrine facility is not a guarantee for eliminating open defecation owing to socio-demographic and environmental factors: The case of Machakel district in Ethiopia
Authors: Temesgen Abathun , Molla Adane Mesafint , Birara Amsalu , Shibabaw Tebkew 
Published: September 2021

Background
Open defecation practice problem is rampant in most rural areas of developing countries, including Ethiopia. To combat this problem, the Ethiopian government implemented different sanitation interventions including Community-Led Total Sanitation and Hygiene (CLTSH). The CLTSH approach is mainly aimed to eradicate open defecation practice through mobilizing the community to construct a latrine facility and utilize it. Although this intervention has significantly improved households’ access to a latrine facility, its impact on bringing behavioral change such as avoiding open defecation is not well studied.

Objective
Our study aimed to assess the prevalence of open defecation among households having their latrine and its determinant factors in rural settings in Northwest Ethiopia.

Methods
A community-based cross-sectional study was conducted in Machakal district from September 1 to 30, 2019. A total of 472 household heads who had a latrine facility and systematically selected from six rural Kebeles of the district, were involved in the study. The data were collected using a structured questionnaire and observational checklist tools through face-to-face interviews and observation methods. Bivariate and multivariable logistic regression models were run to identify the factors that influence open defecation practice. During the multivariable analysis, statistical significance was declared at the p-value of <0.05 with 95% CI.

Results
The prevalence of open defecation practice among household heads who had latrine facility was 27.8% (95% CI, [23.1–32.8]). Female gender (AOR = 2.94, 95% CI [1.13–7.68]), not attending of formal education (AOR = 3.10, CI 95% [1.34–7.13]), having >5 family members (AOR = 1.72, CI 95% [1.05–2.80]), presence of under-five child (AOR = 3.64 CI 95% [2.14–6.21]), preferring leaf as anal cleaning material (AOR = 3.18, CI 95% [1.67–6.08]), having unclean latrine (AOR = 2.15, CI 95% [1.34–3.44]), and having latrine that needs maintenance (AOR = 2.50 CI 95% [1.52–4.11]) variables were associated with open defecation practice.

Conclusions
Among the total respondents, finding more than a quarter of open defecators is concerning for a district that achieved greatly in terms of latrine coverage. This indicates the above-mentioned factors contributed to influence household heads to defecate openly despite having latrines. Therefore, the government and partners need to focus on designing strategies that effectively address determinant factors of open defecation.
How the scientific community responded to the COVID-19 pandemic: A subject-level time-trend bibliometric analysis
Authors: Malekpour Mohammad-Reza , Abbasi-Kangevari Mohsen , Azadnajafabad Sina , Ghamari Seyyed-Hadi , Rezaei Negar , Rezazadeh-Khadem Sahba , Rezaei Nazila , Aminorroaya Arya , Abdolhamidi Elham , Mohammadi Fateh Sahar , Haghshenas Rosa , Roshani Shahin , Ahmadi Naser , Jamshidi Kosar , Naderimagham Shohreh , Farzadfar Farshad 
Published: September 2021

BackgroundCOVID-19 has triggered an avalanche of research publications, the various aspects of which need to be assessed. The objective of this study is to determine the scientific community’s response patterns to COVID-19 through a bibliometric analysis of the time-trends, global contribution, international collaboration, open-access provision, science domains of focus, and the behavior of journals.MethodsThe bibliographic records on COVID-19 literature were retrieved from both PubMed and Scopus. The period for searching was set from November 1, 2019, to April 15, 2021. The bibliographic data were coupled with COVID-19 incidence to explore possible association, as well as World Bank indicators and classification of economies.ResultsA total of 159132 records were included in the study. Following the escalation of incidences of COVID-19 in late 2020 and early 2021, the monthly publication count made a new peak in March 2021 at 20505. Overall, 125155 (78.6%) were national, 22548 (14.2%) were bi-national, and 11429 (7.2%) were multi-national. Low-income countries with 928 (66.8%) international publications had the highest percentage of international. The open-access provision decreased from 85.5% in February 2020 to 62.0% in April 2021. As many as 82841 (70.8%) publications were related to health sciences, followed by life sciences 27031 (23.1%), social sciences 20291 (17.3%), and physical sciences 15141 (12.9%). The top three medical subjects in publications were general internal medicine, public health, and infectious diseases with 28.9%, 18.3%, and 12.6% of medical publications, respectively.ConclusionsThe association between the incidence and publication count indicated the scientific community’s interest in the ongoing situation and timely response to it. Only one-fifth of publications resulted from international collaboration, which might lead to redundancy without adding significant value. Our study underscores the necessity of policies for attraction of international collaboration and direction of vital funds toward domains of higher priority.
CAD-to-real: enabling deep neural networks for 3D pose estimation of electronic control units
Authors: Bäuerle Simon , Böhland Moritz , Barth Jonas , Reischl Markus , Steimer Andreas , Mikut Ralf 
Published: September 2021

Abstract
Image processing techniques are widely used within automotive series production, including production of electronic control units (ECUs). Deep learning approaches have made rapid advances during the last years, but are not prominent in those industrial settings yet. One major obstacle is the lack of suitable training data. We adapt the recently developed method of domain randomization to our use case of 3D pose estimation of ECU housings. We create purely synthetic data with high visual diversity to train artificial neural networks (ANNs). This enables ANNs to estimate the 3D pose of a real sample part with high accuracy from a single low-resolution RGB image in a production-like setting. Requirements regarding measurement hardware are very low. Our entire setup is fully automated and can be transferred to related industrial use cases.
Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
Authors: Zareen Shehzad , Khan Shahid Niaz , Adnan Muhammad , Haleem Sumbal , Ali Rehman , Alnomasy Sultan F. 
Published: September 2021

Abstract
Malaria is an intraerythrocytic parasitic disease caused by the genus Plasmodium of which Plasmodium vivax and Plasmodium falciparum are the major species. The high cost and associated side effects of antimalarial drugs triggered research about medicinal plants to develop alternative and low-cost drugs with lesser side effects. Therefore, this study was designed to investigate the antiplasmodial activity of the Eucalyptus obliqua L’Hér. leaf extract against P. vivax and its phytochemicals in in vitro. The methanolic extract of E. obliqua was prepared and different concentrations of the crude extract and phytochemicals were used against P. vivax. The methanolic extract of E. obliqua showed profound antiplasmodial activity (LD50 0.084 mg/mL; 80.04%) at 0.1 mg/mL concentration after 24 h. Alkaloids, flavonoids, saponins, and tannins were found in the E. obliqua methanolic extract. Only alkaloids at the concentration (0.1 mg/mL) exhibited 60.93% inhibition of P. vivax. The methanolic extract of E. obliqua exhibits antiplasmodial activity in vitro. However, in vivo efficacy is an important aspect in the testing of medicinal plants against parasitic infections and should be evaluated in future.
A Bayesian semiparametric accelerate failure time mixture cure model
Authors: Wang Yijun , Wang Weiwei , Tang Yincai 
Published: September 2021

Abstract
The accelerated failure time mixture cure (AFTMC) model is widely used for survival data when a portion of patients can be cured. In this paper, a Bayesian semiparametric method is proposed to obtain the estimation of parameters and density distribution for both the cure probability and the survival distribution of the uncured patients in the AFTMC model. Specifically, the baseline error distribution of the uncured patients is nonparametrically modeled by a mixture of Dirichlet process. Based on the stick-breaking formulation of the Dirichlet process, the techniques of retrospective and slice sampling, an efficient and easy-to-implement Gibbs sampler is developed for the posterior calculation. The proposed approach can be easily implemented in commonly used statistical softwares, and its performance is comparable to fully parametric method via comprehensive simulation studies. Besides, the proposed approach is adopted to the analysis of a colorectal cancer clinical trial data.
Functional verification of cyber-physical systems containing machine-learnt components
Authors: Moradkhani Farzaneh , Fränzle Martin 
Published: September 2021

AbstractFunctional architectures of cyber-physical systems increasingly comprise components that are generated by training and machine learning rather than by more traditional engineering approaches, as necessary in safety-critical application domains, poses various unsolved challenges. Commonly used computational structures underlying machine learning, like deep neural networks, still lack scalable automatic verification support. Due to size, non-linearity, and non-convexity, neural network verification is a challenge to state-of-art Mixed Integer linear programming (MILP) solvers and satisfiability modulo theories (SMT) solvers [2], [3]. In this research, we focus on artificial neural network with activation functions beyond the Rectified Linear Unit (ReLU). We are thus leaving the area of piecewise linear function supported by the majority of SMT solvers and specialized solvers for Artificial Neural Networks (ANNs), the successful like Reluplex solver [1]. A major part of this research is using the SMT solver iSAT [4] which aims at solving complex Boolean combinations of linear and non-linear constraint formulas (including transcendental functions), and therefore is suitable to verify the safety properties of a specific kind of neural network known as Multi-Layer Perceptron (MLP) which contain non-linear activation functions.
Development and assessment of a low-health-literacy, pictographic adrenal insufficiency action plan
Authors: Reeves Patrick T. , Packett Ashley C. , Burklow Carolyn Sullivan , Echelmeyer Sofia , Larson Noelle S. 
Published: September 2021

Abstract

Objectives
Adrenal insufficiency (AI) is an overall rare disorder characterized by the chronic need for pharmacotherapy to prevent threat to life. The Pediatric Endocrine Society has recommended the use of clinical action tools to improve patient education and help guide acute management of AI. We aimed to develop and assess an easy-to-use, patient-friendly, evidence-based, personalized pictogram-based adrenal insufficiency action plan (AIAP) to aid in the management of AI in children.

Methods
Patients/caregivers (P/Cs) responded to surveys which measured the concepts of transparency, translucency, and recall in order to assess the pictograms. Readability was assessed using six formulas to generate a composite readability score. Quality was graded by P/Cs using the Consumer Information Rating Form (CIRF) (>80% rating considered acceptable). Understandability and actionability was assessed by medical librarians using the Patient Education Materials Assessment Tool-Printable (PEMAT-P) (>80% rating was acceptable). Suitability was evaluated by clinicians using the Suitability Assessment of Materials (SAM) instrument (>70% rating considered superior).

Results
All pictograms met criteria for inclusion in the AIAP. Composite readability score=5.4 was consistent with a fifth-grade level. P/Cs (n=120) judged the AIAP to be of high quality with CIRF rating=85.2%. Three medical librarians rated the AIAP to have 100% understandability and 100% actionability. Thirty-three clinicians completing the SAM generated a suitability rating of 90.0%.

Conclusions
The AIAP visually highlights individualized care plan components to facilitate optimized preventative and acute AI care. Further investigation will determine if AIAP improves clinical outcomes for patients with AI.