bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice
Authors: Zhao Jing , Zhou Ting , Lu Jing-Ze , Ye Dan , Mu Sheng , Tian Xin-Hui , Zhang Wei-Dong , Ma Bing-Liang 
Published: June 2021

Primary plant metabolites can be used for artificial preparation of natural deep eutectic solvents (NADESs), which have strong dissolving capacity, good biocompatibility, and biodegradability. In this study, for the first time, we verified that NADESs were present in Coptidis Rhizoma extract and systematically investigated its effects and mechanisms on the pharmacokinetics of oral berberine hydrochloride (BBR), a co-existing bioactive constituent. First, three LC-MS/MS based methods were established and fully validated to determine the levels of 11 primary metabolites in Coptidis Rhizoma extract. According to the weight ratio of four major primary metabolites in the Coptidis Rhizoma extract, a stable “endogenous” NADES was prepared using the heating method by the addition of 350 μl of water to 1,307.8 mg of the mixture of malic acid (490.5 mg), glucose (280.6 mg), sucrose (517.7 mg), and choline chloride (19.0 mg). The prepared NADES showed significant acute toxicity in mice and cytotoxicity in MDCK-MDR1 cells. However, after being diluted 10 times or 100 times, the NADES had no significant acute toxicity or cytotoxicity, respectively. The dilutions of the NADES significantly increased the water solubility of BBR, reduced its efflux in gut sacs and MDCK-MDR1 cell monolayer, and improved its metabolic stability in intestinal S9. In addition, the NADES dilutions reversibly opened the tight junctions between the enterocytes in the gut sacs. Moreover, the NADES dilutions significantly improved the exposure levels of BBR in the portal vein and livers of mice that were administered oral BBR. Malic acid was identified as a major component in the NADES in terms of solubility, acute toxicity, cytotoxicity, and pharmacokinetic-improving effects on oral BBR. In conclusion, the primary metabolites of Coptidis Rhizoma extract could form “endogenous” NADES, and its dilutions improve the pharmacokinetics of oral BBR. This study demonstrates the synergistic interaction of the constituents of Coptidis Rhizoma extract and the potential use of the NADES dilutions in oral BBR delivery.
Placebo Effects on Stress, but Not on Pain Reports. A Multi-Experiment Study
Authors: Vambheim Sara Magelssen , Daniali Hojjat , Flaten Magne Arve 
Published: June 2021

BackgroundContextual factors, such as participant/experimenter sex may moderate the placebo effects. We tested whether the participant and experimenter sex modulated placebo effects on experimentally induced pain and associated stress.ObjectiveTo investigate if (i) participant sex and (ii) experimenter sex influence placebo analgesia and subjective and physiological stress in two experiments employing a within-subjects and a mixed design, respectively. Placebo effects were investigated in pain reports, stress, and blood pressure.MethodsParticipants received painful stimulations and a placebo cream. In Experiment One (N = 59) participants underwent a placebo condition (PC) and a natural history condition (NHC) in random order. A placebo cream was applied in the PC and then the heat stimulation temperature was surreptitiously lowered. Identical stimulations were administered in the NHC, but with no cream, no information, and no lowered temperature. In Experiment Two, participants (N = 93) were randomly assigned to three groups receiving either a placebo cream with surreptitiously lowered intensity of electric stimuli (Placebo, PG), a placebo cream (Cream-Control, CCG) without changing the stimuli, or lowered intensity, but with no cream (Pain-Control, PCG) in a mixed design. All participants in both experiments received the same stimuli in the post-test as in the pre-test. Four experimenters (two females) in Experiment One, and five experimenters (two females) in Experiment Two conducted the studies.ResultsNo placebo effect was seen on pain. However, there were placebo effects on stress, moderated by participant and experimenter sex: in Experiment One males in the PC had lower diastolic blood pressure (DBP) compared to males in the NHC. Participants in the PC had lower DBP compared to the NHC when tested by a female. In Experiment Two, participants expected more cream effectiveness when a female experimenter administered it, and reported lower stress in the PG compared to the PCG when tested by females.ConclusionOur findings highlight a distinction between placebo effects on pain and on associated stress. Secondly, female experimenters recorded lower physiological and subjective stress, higher effectiveness expectations, and lower pain from both sexes compared to male experimenters. Possible reasons for the failure to find a pain placebo effect are discussed.
Identifying the ‘Active Ingredients' of an Effective Psychological Intervention to Reduce Fear of Cancer Recurrence: A Process Evaluation
Authors: Kan Janice M. , Dieng Mbathio , Butow Phyllis N. , Mireskandari Shab , Tesson Stephanie , Menzies Scott W. , Costa Daniel S. J. , Morton Rachael L. , Mann Graham J. , Cust Anne E. , Kasparian Nadine A. 
Published: June 2021

Purpose: Psychological interventions targeting fear of cancer recurrence (FCR) are effective in reducing fear and distress. Process evaluations are an important, yet scarce adjunct to published intervention trials, despite their utility in guiding the interpretation of study outcomes and optimizing intervention design for broader implementation. Accordingly, this paper reports the findings of a process evaluation conducted alongside a randomized controlled trial of a psychological intervention for melanoma patients.Methods: Men and women with a history of Stage 0–II melanoma at high-risk of developing new primary disease were recruited via High Risk Melanoma Clinics across Sydney, Australia and randomly allocated to receive the psychological intervention (n = 80) or usual care (n = 84). Intervention participants received a tailored psycho-educational resource and three individual psychotherapeutic sessions delivered via telehealth. Qualitative and quantitative data on intervention context, processes, and delivery (reach, dose, and fidelity), and mechanisms of impact (participant responses, moderators of outcome) were collected from a range of sources, including participant surveys, psychotherapeutic session audio-recordings, and clinical records.Results: Almost all participants reported using the psycho-educational resource (97%), received all intended psychotherapy sessions (96%), and reported high satisfaction with both intervention components. Over 80% of participants would recommend the intervention to others, and a small proportion (4%) found discussion of melanoma-related experiences confronting. Perceived benefits included enhanced doctor-patient communication, talking more openly with family members about melanoma, and improved coping. Of potential moderators, only higher FCR severity at baseline (pre-intervention) was associated with greater reductions in FCR severity (primary outcome) at 6-month follow-up (primary endpoint).Conclusions: Findings support the acceptability and feasibility of a psychological intervention to reduce FCR amongst individuals at high risk of developing another melanoma. Implementation into routine melanoma care is an imperative next step, with FCR screening recommended to identify those most likely to derive the greatest psychological benefit.
Parent Perceptions of Changes in Child Physical Activity During COVID-19 Stay-At-Home Orders
Authors: Eyler Amy A. , Schmidt Laurel , Kepper Maura , Mazzucca Stephanie , Gilbert Amanda , Beck Alan 
Published: June 2021

Purpose: The purpose of this study was to explore parent perceptions of changes in child physical activity during COVID-19 stay-at-home orders.Design: A cross-sectional study.Setting: The research team used social media, relevant organizations, and neighborhood groups to distribute the survey link in May and June of 2020.Subjects: A convenience sample of parents of children aged 5–12.Measures: Survey to assess parental perceptions of changes in children's physical activity before and during stay-at-home orders, and environmental and social barriers to physical activity.Analysis: Results were analyzed using descriptive statistics, bivariate comparisons, and multinomial-logistic regression models with covariates of environmental factors, social factors, and frequency of factors as barriers on association with perceived physical activity change.Results: Data from 245 parents were analyzed. A majority (63.7%) of parents reported a decrease in children's physical activity during stay-at-home orders. More parents indicated social barriers (e.g., lack of access to playmates) than environmental barriers (e.g., lack of access to neighborhood play spaces) to children's physical activity. In multivariate analyses, the odds of parents reporting decreased physical activity was greater for those reporting lack of playmates (OR = 4.72; 95% CI: 1.99–11.17) and lack of adult supervision (OR = 11.82; 95% CI: 2.48–56.28) as barriers. No environmental barriers were significantly associated with decreased children's physical activity.Conclusion: The unique aspects of the COVID-19 pandemic provide a natural experiment for developing social and environmental strategies to improve children's overall physical activity. Assessing parental perceptions is a way to inform these future efforts.
Just “Like Coffee” or Neuroenhancement by Stimulants?
Authors: Franke Andreas G. , Koller Gabriele , Krause Daniela , Proebstl Lisa , Kamp Felicia , Pogarell Oliver , Jebrini Tarek , Manz Kirsi , Chrobok Agnieszka I. , Soyka Michael 
Published: June 2021

Introduction: Pharmacological neuroenhancement (PN) is a topic of increasing importance and prevalence among students. However, there is a lack of differentiating PN substances, according to their psychoactive effects. In particular, there is a lack of data about PN by caffeinated drinks, even if coffee is a common and broadly used Neuroenhancer because of its cognitively enhancing effects regarding wakefulness, alertness and concentration.Materials and Methods: A web-survey was developed for German students and alumni about the non-medical use of caffeine for PN contained questions about coffee, caffeinated drinks and energy drinks, caffeine pills and methylxanthine tea regarding frequency and further contextual factors.Results: Six hundred and eighty-three participants completed the survey. Nearly all participants knew about PN (97.7%). 88.1% admitted using some over-the-counter substances. For PN purposes, coffee was used by 72.9% followed by energy drinks (68.2%) and cola drinks (62.4%). Methylxanthine containing tea was used for PN purposes, too (black tea 52.3%, green tea 51.7%). 1.8% admitted using illegal substances or prescription drugs, too.Discussion: Using legal methylxanthine containing drinks for PN seems to be extremely common with coffee and energy drinks being the preferred substances, while illegal and prescription drugs are only minimally used. Further studies should investigate the awareness of methylxanthine containing drinks as well as its character to be a flavoring drink or a neuroenhancer.
Motivation for Rehabilitation in Patients With Subacute Stroke: A Qualitative Study
Authors: Yoshida Taiki , Otaka Yohei , Osu Rieko , Kumagai Masashi , Kitamura Shin , Yaeda Jun 
Published: June 2021

Background:Motivation is essential for patients with subacute stroke undergoing intensive rehabilitation. Although it is known that motivation induces behavioral changes toward rehabilitation, detailed description has been lacking. Motivation can be intrinsic or extrinsic; however, it is unclear which type of factors mainly motivates patients' daily rehabilitation.Purpose:This study aimed to examine the factors influencing patients' motivation and to explore the behavioral changes induced by motivation, especially age-related differences.Method:Twenty participants (mean age 65.8 years [standard deviation 13.7]) who had a subacute stroke and underwent rehabilitation at a convalescent hospital were recruited using convenience sampling. Semi-structured interviews were conducted by an occupational therapist with an interview topic guide regarding factors influencing motivation and how it affects behavioral change. Interviews were recorded, transcribed to text, and analyzed by three occupational therapists using thematic analysis. The participants were divided into two groups: aged patients (aged ≥ 65 years) and middle-aged patients (aged &lt; 65 years), and data were analyzed according to the groups. This study was conducted according to the consolidated criteria for reporting qualitative research.Results:Seven core categories were identified as factors influencing patients' motivation: patients' goals, experiences of success and failure, physical condition and cognitive function, resilience, influence of rehabilitation professionals, relationships between patients, and patients' supporters. The first four and last three core categories were further classified as personal and social-relationship factors, respectively. The categories related to intrinsic motivation such as enjoyment of rehabilitation itself were not derived. In both age-groups, motivation affected the frequency of self-training and activity in daily lives. In some aged patients, however, high motivation restrained their self-training to conserve their physical strength for rehabilitation by professionals. Some aged patients do not express their high motivation through their facial expressions and conversations compared to middle-aged patients; therefore, motivation is not always observable in aged patients.Conclusions:Interventions tailored to extrinsic factors are important for maintaining patients' motivation. Observational evaluation may lead to mislabeling of their motivation, especially for aged patients. Rehabilitation professionals should use validated evaluation scales or patients' narratives to assess patients' motivation.
TINJAUAN SINGKAT OPTIMALISASI PEMANFAATAN ENERGI SURYA PADA SEKTOR RUMAH TANGGA
Authors: Pratomo Ligan Budi , Sinaga Nazaruddin 
Published: June 2021

Energy use always increases, especially fossil energy. Through the National Energy Policy, the government continues to strive to increase the role of new and renewable energy sources so as to reduce dependence on fossil energy. Solar power generation is a type of renewable energy generator that capable to convert solar energy to electric energy. The main components of solar power generatios are batteries, solar panels, charger controllers, and inverters. Solar power generations technology itself is always being developed, such as automatic monitoring and sun tracking systems designed to improve system performance. One of the applications of solar power generations is in the household sector. In this sector consumes 49% of the national electricity energy in 2018. This type of generator is categorized as a roof solar power generations. Based on existing data, there were 1400 roof solar power generations users in September 2019. The development of solar energy utilization for the household sector is very appropriate because it can help achieve renewable energy about 23% in 2025 and 31% in 2050 in the national energy mix.
Pengembangan Sistem Informasi Pengusulan, Penilaian Dan Penetapan Angka Kredit Guru (SIPULPENPAKGURU)
Authors: Kusdiawan Wawan 
Published: June 2021

Teacher Performance Assessment is one component in determining the ratings of Credit Master obtained through nomination DUPAK (List of Proposed Establishment of Credit). It is a collection of files that match the rules, bound and delivered to the Secretariat of the assessment team lists the ratings of teacher performance through a number of credits submitted by individual teachers or educators who have become civil servants are useful as one of the requirements at the higher promotion and/or salary or welfare of teachers as functional as well as teacher performance assessment materials or educators such.
The problem faced today is publishing mechanism DUPAK still manual, especially in the process of assessment by the Assessment Team PAK. Thus, in the assessment process in the official report sheet assessment is done in handwritten form in a way, made possible mistakes or errors at the time of entry into application PAK. Teacher understanding of the mechanism of determination of PAK is still low, and the limited number of personnel for data processing. These problem will eventually be detrimental to civil servants, especially teachers concerned.With the implementation of this applications especially teachers with considerable amounts expected to help because it can improve the accuracy and is able to speed up service. Through the implementation of this SIPULPEKGURU expected nomination process that was previously done manually with the innovations made in this SIPULPENPAKGURU application development, finaly can be made online so that more accurate data, teachers can also monitor the progress of his nomination.
Perancangan Sistem Informasi Pendidikan Dan Pelatihan (Diklat) Di Balai Besar Pelatihan Kesehatan Ciloto
Authors: Setiyani Lila 
Published: June 2021

Balai Besar Pelatihan Kesehatan (BBPK) Ciloto yang mempunyai tugas pokok melaksanakan pendidikan dan pelatihan (diklat) serta pengembangan sumber daya manusia kesehatan masyarakat. Dalam pengelolaan diklat BBPK Ciloto sering mengalami kesulitan dalam proses administrasi registrasi pelatihan. Pengelolaan yang ada sekarang menggunakan website namun pengolahan datanya dilakukan dengan microsoft office excel , untuk komunikasi antar unit kerja masih menggunakan manual yaitu menggunakan email. Untuk itu dibutuhkan suatu sistem informasi yang dapat terintegrasi antar unit kerja di BBPK Ciloto sehingga proses pengolahan data dan komunikasi antar unit kerja dapat dilakukan dengam mudah dan terdokumentasi dengan baik. Permasalahan tersebut melatarbelakangi peneliti untuk mengembangkan sistem informasi diklat berbasis web. Dalam proses pengembangan sistem, peneliti menggunakan metode waterfall dan php. Hasil penelitian ini adalah sebuah sistem informasi yang dapat mengelola diklat dan kemudahan komunikasi antar unit kerja BBPK Ciloto. Berdasarkan hasil pengujian, menurut pengguna sistem informasi diklat ini cukup memberikan manfaat dan solusi dari permasalahan yang ada.
Analisis Dan Perancangan Sistem Informasi Pengelolaan Kendaraan Operasional Berbasis Web Pada PT RODA PEMBINA NUSANTARA
Authors: Kurniawan Anton , Awalludin Dudi 
Published: June 2021

Penelitian yang dilakukan oleh penulis di PT Roda Pembina Nusantara untuk menganalisis dan mengidentifikasi masalah yang ada pada pengelolaan kendaraan operasional. Tujuan dari penelitian ini adalah untuk merancang sistem informasi pengelolaan kendaraan operasional dengan menggunakan web. Pengelolaan kendaraan operasional yang dimaksudkan adalah membuat jadwal pemeliharaan kendaraan, membuat surat permohonan perbaikan, membuat surat perintah kerja, membuat laporan jadwal servis, membuat laporan pemeliharaan dan laporan perbaikan kendaraan.
Metode pengembangan sistem yang digunakan yaitu SDLC (System Development Life Cycle) dengan model waterfall yang memiliki 6 tahapan yaitu: System Engineering, requirements analysis, design, coding, testing, maintenance. Hasil wawancara dan observasi pada sistem informasi pengelolaan kendaraan operasional PT Roda Pembina Nusantara, pada pendokumentasian pemeliharaan dan perbaikan kendaraan masih belum terdokumentasi dengan baik. Sehingga informasi yang dibutuhkan untuk pemeliharaan dan perbaikan kendaraan menjadi kurang akurat. Pengelolaan kendaraan operasional yang terkomputerisasi berbasis web diharapkan dapat mengurangi data yang tidak terdokumentasi dengan baik sehingga informasi yang didapatkan menjadi lebih akurat, sistem informasi pengelolaan kendaraan operasional berbasis web dapat berjalan dengan baik, karena dapat menggantikan sistem yang sebelumnya sudah berjalan.
Analisis Dan Perancangan Sistem Informasi Pengupahan Karyawan Outsourcing Pada PT MULTI MANDIRI Berbasis Web
Authors: Efriana Rinah , Malfiany Rini 
Published: June 2021

Pengupahan karyawan outsourcing pada PT Multi Mandiri belum maksimal sehingga dapat menyebabkan lamanya proses pengupahan dalam satu periode berdasarkan pengupahan perminggunya sering terjadi kesalahan-kesalahan akibat proses pencatatan manual yang selama ini dilakukan. Maka dari itu perlu dibangun sistem informasi pengupahan karyawan outsourcing agar dapat menyajikan informasi secara cepat dan akurat serta mengurangi terjadinya kesalahan-kesalahan dalam memproses pengupahan karyawan outsourcing. Metode penelitian yang digunakan adalah metode SDLC dengan model waterfall dimulai dari analisis dan observasi terhadap sistem yang berjalan di perusahaan. Kemudian dari data yang ada dilakukan perancangan sistem informasi pengupahan karyawan outsourcing yang disesuaikan dengan kebutuhan perusahaan. Sistem informasi pengupahan karyawan outsourcing berbasis web yang dirancang dapat mengelola data berdasarkan data absen dan data lembur disetiap harinya, untuk mengurangi pencatatan manual pengupahan karyawan outsourcing agar data yang disajikan sesuai dengan yang diharapkan dan dapat mengurangi kesalahan yang biasa terjadi ketika menggunakan sistem yang lama.
Penerapan Metode Jaringan Syaraf Tiruan Untuk Prediksi Kebutuhan Beban Listrik
Authors: Purwoharjono Purwoharjono 
Published: June 2021

Penelitian ini bertujuan untuk memprediksi kebutuhan beban listrik. Prediksi kebutuhan beban listrik ini dilakukan dengan menggunakan Metode Jaringan Syaraf Tiruan (JST). JST ini menggunakan algoritma backpropagation. Lokasi penelitian ini dilakukukan di Kota Pontianak Kalimantan Barat. Peningkatan konsumsi listrik diwilayah Kota Pontianak mengalami peningkatan setiap tahunnya namun tidak diimbangi dengan pemenuhan energi listrik yang mencukupi.
Berdasarkan hasil yang diperoleh dari simulasi menggunakan algoritma backpropagation ini dapat dikatakan bahwa algoritma backpropagation ini dapat bekerja dengan baik dalam mengenali data masukan yang diberikan ke sistem karena tingkat kesalahan menggunakan Mean Square Error (MSE) dan Mean Absolute Percentage Error (MAPE) relatif kecil.
Resapan Dengan Koefisien Permeabilitas Batuan Desain Sumur Lapisan Bawah
Authors: Lies Kurniawati Wulandari  , Kustamar  
Published: June 2021

Banjir masih menjadi salah satu bencana yang menjadi perhatian, karena memiliki daya rusak yang cukup mengganggu, bahkan menimbulkan kerugian dan membahayakan keselamatan. Mayoritas banjir di dominasi oleh air yang merupakan akumulasi dari air limpasan permukaan, sehingga untuk mengendalikannya harus difokuskan pada upaya bagaimana memaksimalkan resapan air hujan ke dalam tanah. Mayoritas pemilik lahan pada daeran tangkapan hujan yang pada umumnya disebut daerah aliran sungai (DAS) adalah masyarakat. Oleh karenanya, dalam upaya pengendaliannya harus melibatkan masyarakat. Konstruksi sederhana yang cukup efektif digunakan adalah sumur resapan, karena memiliki kapasitas yang cukup besar akan tetapi mudah dibuat oleh masyarakat, dengan resiko yang relative kecil. Namun demikian dari tinjuan system drainase, penggunaan sumur resapan memerlukan biaya yang lebih besar dibandingjkan dengan pembuatan saluran drainase untuk mengalirkan hujan ke sungai. Oleh karenanya diperlukan upaya optimasi desain untuk mendapatkan biaya yang paling murah. Desain akan tepat jika digunakan data yang akurat, oleh karenanya dilakukan pengujian koefisien permeabilitas batuan bawah permukaan.