bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA-29a promotes the proliferation of human nasal epithelial cells and inhibits their apoptosis and promotes the development of allergic rhinitis by down-regulating FOS expression
Authors: Fan Yuqin , Tang Zhiyuan , Sun Jie , Zhao Xiaorui , Li Zhen , Zheng Yiqing , Zeng Xianhai , Feng Juan 
Published: August 2021

ObjectiveTo explore the regulation of microRNA-29a (miR-29a) on FOS in human nasal epithelial cells and its molecular mechanism, as well as the effects of miR-29a on the cell proliferation and apoptosis.MethodsBy cell transfection, gene silencing, quantitative real-time polymerase chain reaction (qRT-PCR), flow cytometry and TUNEL assay (for cell apoptosis), CCK-8 assay (for cell proliferation), dual-luciferase reporter gene assay and Western Blot, it was validated that miR-29a promoted the proliferation of human nasal epithelial cells and inhibited their apoptosis by down-regulating FOS expression in RPMI2650 and HNEpC cell lines.Results①Compared with healthy controls, miR-29a expression was up-regulated and FOS mRNA expression was down-regulated in the nasal tissues from the patients with allergic rhinitis (AR). ②MiR-29a over-expression promoted the proliferation of RPMI2650 cells and HNEpC cells but inhibited their apoptosis. ③MiR-29a targeted at FOS. ④MiR-29a over-expression and FOS silencing both significantly promoted cell proliferation and inhibited cell apoptosis. After transfection with both miR-29a and FOS, there was a decrease in the proliferation but an increase in the apoptosis of cells.⑤MiR-29a promoted the proliferation of human nasal epithelial cells and inhibited their apoptosis by down-regulating FOS expression.ConclusionMiR-29a-/FOS axis can be regarded as a potential marker and a new therapy for AR.
HIV program outcomes for Jamaica before and after “Treat All”: A population-based study using the national treatment services database
Authors: Cushnie Anya , Reintjes Ralf , Lehtinen-Jacks Susanna , Figueroa J. Peter 
Published: August 2021

ObjectiveThe study aims to assess changes in HIV treatment outcomes for Jamaica after the implementation of the WHO Treat All strategy in January 2017, as well as identify variables associated with clinical stage at diagnosis and viral load status, in order to understand implications for enhancing the HIV clinical cascade and boosting progress towards the UNAIDS 90-90-90 targets.MethodThis is a population-based study using the National Treatment Service Information System. The sample consists of persons 15 years and older, placed on treatment before and after Treat All was implemented, across all 4 regional health authorities in Jamaica. Patients were assessed for two binary outcomes: 1. stage at HIV diagnosis (early/baseline CD4 cell count ≧350 cells/mm3, or late/ baseline CD4 <350 cells/mm3), 2. viral load status achieved after ART initiation (suppressed/<1000 copies/ml or non-suppressed/ ≥1000 copies/ml). Categorical variables: age/years, gender and health regions, were investigated using multivariable logistic regression. Adjusted odds ratios and 95% confidence intervals are reported.ResultsAfter Treat All, there was an increase in median baseline CD4 results as the proportion of late diagnoses decreased from 60% to 39%. There was a small increase in viral suppression from 76% to 80%, a decrease in baseline viral load testing from 61% to 46% and an increase in the uptake of first viral load testing after starting treatment from 13% to 19%. Males and persons 40+ years had higher odds of late diagnosis before and after Treat All.ConclusionJamaica’s HIV program outcomes have improved after Treat All was implemented. ART initiation time significantly decreased. Early diagnosis, viral load testing uptake and viral suppression increased. However, there is a need to implement targeted testing for men and persons over 40 years to decrease the frequency of late diagnosis.
Do vulnerable groups access prevention services? Cervical cancer screening and HIV testing among homeless migrant women in the Paris metropolitan area
Authors: Poncet Lorraine , Panjo Henri , Ringa Virginie , Andro Armelle 
Published: August 2021

IntroductionHomeless migrant women, facing adverse living conditions and barriers to legal status, are at risk of cervical cancer, HIV infection and may encounter barriers to screening services. We investigate factors associated with each screening in a population of migrant women in France and aim to determine the mean time since last HIV testing according to duration of residence in France.MethodsWe use data from the DSAFHIR study (Rights and Health of Migrant Women in Emergency Housing) investigating health and migration experience of homeless migrant women housed in emergency housing hotels in the Paris Metropolitan area in 2017. We computed multivariate logistic regression models to investigate no lifetime cervical cancer screening (CCS) and no lifetime HIV test. We used linear regression models to analyze time since last HIV test.ResultsWe included 469 women. 46% of respondents had no lifetime CCS, 31% had no lifetime HIV test. Both screenings were associated with educational attainment and French proficiency. Compared with duration of residence < 1 year, duration ≥ 7 years was associated with a lower likelihood of no lifetime CCS (adjusted Odd Ratio = 0.17; 95% CI = 0.07–0.39). Compared to women born in North Africa, women born in West (aOR = 0.15; 95% CI = 0.07–0.33) and East Africa (aOR = 0.06; 95% CI = 0.02–0.20) were less likely to have no lifetime HIV test. Time since last HIV test increased for each additional year spent in France (coef = 0.21; 95% CI = 0.09, 0.33).ConclusionWhile access to CCS remains poor for recent migrants, HIV testing is more likely to occur shortly after migration.
Serological prevalence of SARS-CoV-2 infection and associated factors in healthcare workers in a “non-COVID” hospital in Mexico City
Authors: Cruz-Arenas Esteban , Cabrera-Ruiz Elizabeth , Laguna-Barcenas Sara , Colin-Castro Claudia A. , Chavez Tatiana , Franco-Cendejas Rafael , Ibarra Clemente , Perez-Orive Javier 
Published: August 2021

Background
Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. In spite of this high mortality, in Mexico the number of confirmed cases and diagnostic tests per million population are lower than for other comparable countries, which leads to uncertainty about the actual extent of the pandemic. In Mexico City, healthcare workers represent an important fraction of individuals with SARS-CoV-2 infection. We performed a cross-sectional study whose objective was to estimate the frequency of antibodies to SARS-CoV-2 and identify associated factors in healthcare workers at a large hospital in Mexico City.

Methods
We conducted a serological survey in a non-COVID national referral teaching hospital. The study population included all the personnel that works, in any capacity, in the hospital. From this population we selected a representative sample of 300 individuals. Blood samples were collected and questionnaires were applied between August 10th and September 9th, 2020.

Results
ELISA results indicate a serological prevalence of SARS-CoV-2 infection of 13.0%. Working in the janitorial and security groups, having an educational level below a university degree, and living with a larger number of people, were all identified as sociodemographic factors that increase the probability of having SARS-CoV-2 infection.

Conclusions
Less favored socioeconomic groups face significantly higher prospects of experiencing SARS-CoV-2 infection and in institutions such as ours, providing janitorial and security workgroups with additional testing and counseling could help to limit the spread of contagion. The rate from the official number of confirmed cases in Mexico City is substantially smaller than the seropositive rate identified in this work.
Stockpiled personal protective equipment and knowledge of pandemic plans as predictors of perceived pandemic preparedness among German general practitioners
Authors: Stöcker Arno , Demirer Ibrahim , Gunkel Sophie , Hoffmann Jan , Mause Laura , Ohnhäuser Tim , Scholten Nadine 
Published: August 2021

Background
The COVID-19 pandemic significantly changed the work of general practitioners (GPs). At the onset of the pandemic in March 2020, German outpatient practices had to adapt quickly. Pandemic preparedness (PP) of GPs may play a vital role in their management of a pandemic.

Objectives
The study aimed to examine the association in the stock of seven personal protective equipment (PPE) items and knowledge of pandemic plans on perceived PP among GPs.

Methods
Three multivariable linear regression models were developed based on an online cross-sectional survey for the period March–April 2020 (the onset of the pandemic in Germany). Data were collected using self-developed items on self-assessed PP and knowledge of a pandemic plan and its utility. The stock of seven PPE items was queried. For PPE items, three different PPE scores were compared. Control variables for all models were gender and age.

Results
In total, 508 GPs were included in the study; 65.16% believed that they were very poorly or poorly prepared. Furthermore, 13.83% of GPs were aware of a pandemic plan; 40% rated those plans as beneficial. The stock of FFP-2/3 masks, protective suits, face shields, safety glasses, and medical face masks were mostly considered completely insufficient or insufficient, whereas disposable gloves and disinfectants were considered sufficient or completely sufficient. The stock of PPE was significantly positively associated with PP and had the largest effect on PP; the association of the knowledge of a pandemic plan was significant but small. PPE scores did not vary considerably in their explanatory power. The assessment of a pandemic plan as beneficial did not significantly affect PP.

Conclusion
The stock of PPE seems to be the determining factor for PP among German GPs; for COVID-19, sufficient masks are the determining factor. Knowledge of a pandemic plans play a secondary role in PP.
Experience and lessons learned from multi-modal internet-based recruitment of U.S. Vietnamese into research
Authors: Vu Milkie , Huynh Victoria N. , Bednarczyk Robert A. , Escoffery Cam , Ta Danny , Nguyen Tien T. , Berg Carla J. 
Published: August 2021

BackgroundAsian-Americans are one of the most understudied racial/ethnic minority populations. To increase representation of Asian subgroups, researchers have traditionally relied on data collection at community venues and events. However, the COVID-19 pandemic has created serious challenges for in-person data collection. In this case study, we describe multi-modal strategies for online recruitment of U.S. Vietnamese parents, compare response rates and participant characteristics among strategies, and discuss lessons learned.MethodsWe recruited 408 participants from community-based organizations (CBOs) (n = 68), Facebook groups (n = 97), listservs (n = 4), personal network (n = 42), and snowball sampling (n = 197). Using chi-square tests and one-way analyses of variance, we compared participants recruited through different strategies regarding sociodemographic characteristics, acculturation-related characteristics, and mobile health usage.ResultsThe overall response rate was 71.8% (range: 51.5% for Vietnamese CBOs to 86.6% for Facebook groups). Significant differences exist for all sociodemographic and almost all acculturation-related characteristics among recruitment strategies. Notably, CBO-recruited participants were the oldest, had lived in the U.S. for the longest duration, and had the lowest Vietnamese language ability. We found some similarities between Facebook-recruited participants and those referred by Facebook-recruited participants. Mobile health usage was high and did not vary based on recruitment strategies. Challenges included encountering fraudulent responses (e.g., non-Vietnamese). Perceived benefits and trust appeared to facilitate recruitment.ConclusionsFacebook and snowball sampling may be feasible strategies to recruit U.S. Vietnamese. Findings suggest the potential for mobile-based research implementation. Perceived benefits and trust could encourage participation and may be related to cultural ties. Attention should be paid to recruitment with CBOs and handling fraudulent responses.
Social capital and dietary patterns in three ethnic minority groups native to Yunnan Province, Southwest China
Authors: Zhang Qiang , Liu Zhitao , Hu Wenmin , Chen Xinguang , Li Juanjuan , Wan Qingqing , Zhao Jiang , Ruan Yuan , Dao Baoqing , Li Yunfei , Min Xiangdong 
Published: August 2021

BackgroundFew studies have focused on the influencing factors of dietary practices among ethnic minority groups in China, particularly from a social capital perspective.MethodsBetween May and September 2019, we conducted a cross-sectional survey among adults (n = 1,813) from three ethnic minority communities (A Chang, De Ang and Jing Po) in Yunnan Province, Southwest China. Dietary intakes during the past 12 months were measured with a 100-item Food Frequency Questionnaire (FFQ), and two forms of social capital (bonding and bridging) were measured using the validated Personal Social Capital Scale 16 (PSCS-16). Principal component factor analysis was used to derive dietary patterns from 20 food groups. Multivariate linear regressions were used to examine the associations between social capital and dietary patterns.ResultsTwo distinct dietary patterns were identified: the traditional and the modern. The traditional pattern was characterized by high consumptions of tubers, poultry, rice, fruits, vegetables and low consumptions of oil and salt, whereas the modern pattern was highly correlated with egg, nut, beverage, snack and oil consumptions. After adjusted for potential confounders, the modern pattern was positively associated with bonding capital (β= 0.066; 95%CI: 0.058, 0.075) and negatively associated with bridging capital (β= -0.017; 95%CI: -0.024, -0.010).ConclusionIn conclusion, an unhealthy dietary pattern was identified among the ethnic minority groups in Southwest China. The influences of people’s social connections on dietary behaviors should be considered in designing and implementing nutrition intervention programs for the population.
Symptomatic response to CPAP in obstructive sleep apnea versus COPD- obstructive sleep apnea overlap syndrome: Insights from a large national registry
Authors: Adler Dan , Bailly Sébastien , Soccal Paola Marina , Janssens Jean-Paul , Sapène Marc , Grillet Yves , Stach Bruno , Tamisier Renaud , Pépin Jean-Louis 
Published: August 2021

Background
The symptomatic response to continuous positive airway pressure (CPAP) therapy in COPD-obstructive sleep apnea overlap syndrome (OVS) compared to OSA syndrome (OSA) alone has not been well studied so far. The aim of this study is to explore main differences in the clinical response to CPAP treatment in OVS compared to OSA alone.

Study design and methods
Using prospective data from the French National Sleep Apnea Registry, we conducted an observational study among 6320 patients with moderate-to-severe OSA, available spirometry, and at least one follow-up visit under CPAP therapy.

Results
CPAP efficacy measured on the residual apnea-hypopnea index and median adherence were similar between OVS and OSA patients. In both groups, the overall burden of symptoms related to sleep apnea improved with CPAP treatment. In a multivariable model adjusted for age, gender, body mass index, adherence to treatment and residual apnea-hypopnea index, OVS was associated with higher odds for persistent morning headaches (OR: 1.37 [95% CI; 1.04; 1.79]; P = 0.02), morning tiredness (OR: 1.33 [95% CI: 1.12; 1.59]; P<0.01), daytime sleepiness (OR; 1.24 [95% CI: 1.4; 1.46]: P<0.01) and exertional dyspnea (OR: 1.26 [95% CI: 1.00;1.58]; P = 0.04) when compared with OSA alone.

Interpretation
CPAP therapy was effective in normalizing the apnea-hypopnea index and significantly improved OSA-related symptoms, regardless of COPD status. CPAP should be offered to patients with OVS on a trial basis as a significant improvement in OSA-related symptoms can be expected, although the range of response may be less dramatic than in OSA alone.
ORGANIZATION OF THE SYSTEM OF EDUCATIONAL SUPPORT OF AIC OF ALTAI KRAI
Authors: Gerauf Yu. V. , Glotova N. I. 
Published: August 2021

In modern conditions, the development of agriculture is possible only with the availability of personnel who have a high professional level. The problem of attracting highly qualified specialists to the industry who are able to use the achieved scientific, technical and innovative potential of agricultural producers remains very urgent at the moment. Financial support from the state, stimulating payments, diversification of production, the emergence of digital technologies increase the prestige of work in agriculture, thereby making the agricultural sector attractive.
The article assesses the formation of a complex of measures to organize a system of educational support for the agro-industrial complex on the materials of the Altai Territory. The authors disclosed the reasons for the «staff shortage» in the region’s agriculture, analyzed the financing of measures aimed at increasing the personnel potential of the agro-industrial complex of the region. The role of the Agrarian University and the Altai Institute for Advanced Studies in the training of highly qualified personnel for agriculture through state funding of educational programs is noted.
Recommendations on the formation of staffing for innovation in the agro-industrial complex with the use of tools of comprehensive state support, which will improve the competitiveness and attractiveness of the agrarian sector in the region, are proposed.
ALTAI TERRITORY: CONSEQUENCES OF THE COVID-19 PANDEMIC AND DIRECTIONS FOR THEIR LEVELING
Authors: Trotskovskiy A. Ya. , Sabyna E. N. 
Published: August 2021

The coronavirus pandemic has an impact not only on the morbidity and mortality from infectious diseases, but also on an increase in unemployment and drop in income, as well as on all areas of life as result of self-isolation and quarantine measures.
Many analytical materials provide an analysis of the state of the economic sphere in our country, but, at the same time, there are very few publications that would relate to the socio-economic situation of the regional economy. The pandemic has impacted all organizations directly or indirectly, but tourism, hospitality, pharmaceuticals, passenger transportation, catering, sports and culture are particularly affected.
The current situation demanded from the state authorities and local self-government significant organizational and financial resources associated with both minimizing losses in the economy: supporting small and mediumsized businesses, the population, and organizing the work of medical institutions experiencing an increased load in terms of reprofiling beds, equipping hospitals with additional equipment, consumables. The authors analyzed the main measures taken by both federal and regional authorities to maintain entrepreneurial activity and the population in the current situation in the Altai Territory. The article provides recommendations aimed at minimizing the consequences of COVID-19.
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
Authors: Harrison Stephen A. , Baum Seth J. , Gunn Nadege T. , Younes Ziad H. , Kohli Anita , Patil Rashmee , Koziel Margaret J. , Chera Harinder , Zhao Jeff , Chakravarthy Manu V. 
Published: August 2021

INTRODUCTION:
AXA1125 and AXA1957 are novel, orally administered endogenous metabolic modulator compositions, specifically designed to simultaneously support multiple metabolic and fibroinflammatory pathways associated with nonalcoholic fatty liver disease (NAFLD). This study assessed safety, tolerability, and biologic activity of AXA1125 and AXA1957 in NAFLD.

METHODS:
In this multicenter, 16-week, placebo-controlled, single-blind, randomized clinical study in subjects with NAFLD stratified by type 2 diabetes, AXA1125 24 g, AXA1957 13.5 g or 20.3 g, or placebo was administered twice daily. Key metabolism (MRI-proton density fat fraction [MRI-PDFF] and homeostasis model assessment of insulin resistance [HOMA-IR]) and fibroinflammation markers (alanine aminotransferase [ALT], corrected T1 [cT1], keratin-18 [K-18] M65, and N-terminal type III collagen propeptide [Pro-C3]) were evaluated. Safety outcomes included adverse events and standard laboratory assessments.

RESULTS:
Baseline characteristics of the 102 enrolled subjects, including 40 with type 2 diabetes, were consistent with presumed nonalcoholic steatohepatitis. AXA1125 showed consistently greater biologic activity than AXA1957 or placebo. Week 16 changes from baseline with AXA1125 vs placebo: MRI-PDFF −22.9% vs −5.7%, HOMA-IR −4.4 vs +0.7, ALT −21.9% vs −7.2%, K-18 M65 −13.6% vs +20.1%, cT1 −69.6 vs +18.3 ms (P < 0.05), and Pro-C3 −13.6% vs −3.6%. Week 16 changes from baseline with AXA1957 20.3 g: MRI-PDFF −8.1%, HOMA-IR +8.4, ALT −20.7%, K-18 M65 6.6%, cT1 −34.7 ms, and Pro-C3 −15.6%. A greater proportion of subjects treated with AXA1125 achieved clinically relevant thresholds: ≥30% MRI-PDFF, ≥17-IU/L ALT, and ≥80-ms cT1 reductions at week 16. Study products were safe and well tolerated with stable lipid and weight profiles.

DISCUSSION:
Both compositions showed multitargeted activity on relevant NAFLD pathways. AXA1125 demonstrated the greatest activity over 16 weeks, warranting continued clinical investigation in nonalcoholic steatohepatitis subjects.
Ideology’s Absent Shadow: A Conversation about Rhetoric
Authors: Johnson Paul Elliott , McKerrow Raymie E. 
Published: August 2021

Abstract
We have been asked to engage in a conversation about the current role of ideology—as critique, as rhetoric, as a framework within which academics operate. Our approach will not seek to write the history of rhetorical critique from an ideological perspective, nor work from extant literature as one might in a traditional research essay. Still, we reference ideas emanating from that literature; instead of the normal “source citation in text,” we will list references at the end. Our ideas do not exist in a vacuum—they are stimulated by our own reading/writing in the area of ideology critique— from the original “ideological turn” to the present day. Hence it seems appropriate to acknowledge where ideas, especially about missing elements or future trajectories in research, come from. This conversation touches on the Cold War afterlife of the public as an ideological force, whiteness’s role in gatekeeping the field, and how political liberalism and those interpellated by it constrain the field’s future(s).
Visual Rhetoric in Flux: A Conversation
Authors: Bruce Caitlin Frances , Finnegan Cara A. 
Published: August 2021

Abstract
In this conversation series, we discuss some of the enduring and evolving interests that the subfield of visual rhetoric provokes for us. We begin with how we found visual rhetoric; questions of disciplinarity and methodology; issues of archive and field; concerns about the objects and scenes for visual rhetoric; and conclude with a focus on the future, core and evolving concepts, and pedagogy.