bluuebunny/crossref_metadata_2025_split huggingface dataset:
Big data based analytic model to predict and classify breast cancer using improved fractional rough fuzzy K‐means clustering and labeled ensemble classifier algorithm
Authors: K Srikanth. , Zahoor Ul Huq S. , Siva Kumar A. P. 
Published: December 2021

AbstractBreast cancer is a very dangerous disease that mainly affects women. It is a deadliest disease that highly affects the women's life. Therefore, it is necessary to predict and classify this deadly disease for early diagnosis. There exist numerous data mining techniques for early prediction and classification of this disease. The big data based analytical model provides the better solution for storing, manipulating, and analyzing a great number of mammographic images. In this article, a new improved fractional rough fuzzy K‐means clustering strategy is considered for disease prediction. Then, a new Tunicate Swarm Algorithm (TSA) is introduced to optimize the weight parameters. TSA is a bio‐inspired metaheuristic optimization approach. Finally, the labeled ensemble classifier (LEC) is utilized for classifying the stages of breast cancer as malignant and benign. Here, the data is randomly generated from breast cancer Wisconsin dataset (diagnosis) obtainable on UCI machine learning repository. The proposed strategy is compared with different existing strategies, like Logistic Regression Classifier, Random Forest Classifier. From the analysis, it is observed that the proposed big data based analytical model using LEC provides 99.3% accuracy that is very high when compared to the accuracy of existing approaches.
Spatial matrix completion for spatially misaligned and high‐dimensional air pollution data
Authors: Vu Phuong T. , Szpiro Adam A. , Simon Noah 
Published: December 2021

AbstractIn health‐pollution cohort studies, accurate predictions of pollutant concentrations at new locations are needed, since the locations of fixed monitoring sites and study participants are often spatially misaligned. For multi‐pollution data, principal component analysis (PCA) is often incorporated to obtain low‐rank (LR) structure of the data prior to spatial prediction. Recently developed predictive PCA modifies the traditional algorithm to improve the overall predictive performance by leveraging both LR and spatial structures within the data. However, predictive PCA requires complete data or an initial imputation step. Nonparametric imputation techniques without accounting for spatial information may distort the underlying structure of the data, and thus further reduce the predictive performance. We propose a convex optimization problem inspired by the LR matrix completion framework and develop a proximal algorithm to solve it. Missing data are imputed and handled concurrently within the algorithm, which eliminates the necessity of a separate imputation step. We review the connections among those existing methods developed for spatially misaligned multivariate data, and show that our algorithm has lower computational burden and leads to reliable predictive performance as the severity of missing data increases.
Rapid renutrition improves health status in severely malnourished inpatients with AN ‐ score‐based evaluation of a high caloric refeeding protocol in severely malnourished inpatients with anorexia nervosa in an intermediate care unit
Authors: Cuntz Ulrich , Körner Thorsten , Voderholzer Ulrich 
Published: December 2021

AbstractObjectiveRefeeding syndrome is a feared complication of refeeding patients with anorexia nervosa. There are now a number of controlled studies showing that refeeding with an initial high calorie count is more beneficial than cautious refeeding and is safe under continuous monitoring. However, there have yet not been studies in severe anorexia nervosa.MethodWe present an observational study in two different samples. The first sample consists of those 1075 out of a total of 3230 patients with anorexia nervosa treated in our hospital within 4 years for whom a complete admission laboratory was available and who had an age of at least 18 years at admission. A risk score was calculated from the number of pathological laboratory values out of 12 parameters indicating either refeeding syndrome or health hazards related to malnutrition. The second sample was obtained from a special ward for patients with eating disorders medically at‐risk. During the period in question, 410 patients with anorexia nervosa were treated there. 142 patients had a BMI of 13 or less and at the same time a complete data set with the mentioned 12 laboratory parameters at admission and weekly in the following 4 weeks after admission.ResultsThe risk represented by the laboratory parameters is significantly and negatively correlated to BMI and much higher for the group of patients with a BMI below 13 than for those with a higher BMI (χ2 sig < 0.000). The 142 patients in the special care unit gain an average of more than 4.1 kg within 4 weeks on the high‐calorie diet. With this rapid weight gain, the risk score decreases highly significantly. Neither hypophosphatemia nor rhabdomyolysis is found under phosphate substitution. Hyperhydration occurred often, which manifests itself in the drop in haematocrit by the second week.DiscussionUnder thorough medical surveillance, supplementation of phosphate and thiamine, and substitution of electrolytes whenever necessary rapid renutrition appeared to be save even in extremely malnourished inpatients with anorexia nervosa. As measured by the laboratory values, the health status of the severely malnourished patients improves significantly on a high‐calorie diet. Except for hyperhydration, there was no evidence of a refeeding syndrome.
Soil Contamination and Bioaccumulation of Heavy Metals by a Tropical Earthworm Species (Alma nilotica) at Informal E-Waste Recycling Sites in Douala, Cameroon
Authors: Nfor Brian , Fai Patricia Bi Asanga , Tamungang Simon Awafor , Fobil Julius N. , Basu Niladri 
Published: December 2021

Abstract
Soil contamination at electronic waste (e-waste) recycling sites is pervasive, though many locations have yet to be studied. While such contamination can present risks to soil organisms, little is known on the risks to native species. The objective of the present study was to assess soil contamination by heavy metals at e-waste recycling sites, and the potential of Alma nilotica, a native earthworm species, to bioaccumulate these metals. Soil samples collected from eight informal e-waste recycling sites and two non-e-waste sites in Douala, Cameroon, were analyzed for metal content. Metal concentrations in earthworm juveniles exposed to the soils for 21 days followed by a 14-day post-exposure period were measured weekly. Mean soil metal concentrations at e-waste sites ranked as Cu &gt; Pb &gt; Zn &gt; Hg &gt; Ni &gt; As &gt; Cd &gt; Co &gt; Cr. Based on contamination factors, soil contamination ranged from “moderate” (Cr), through “considerable” (Co and Cd), to “very high” for the rest of the metals. Based on the modified degree of contamination and risk index, all e-waste sites had “ultra-high” contamination with Ni, Pb, and Zn posing very high ecological risks and Bonaberi being the most contaminated site. There was a positive correlation between soil metal concentrations and metal accumulation (retention) by eathworms, but Hg and Co had the highest bioaccumulation factors (BAFs) despite having low soil concentrations. These results document that e-waste sites in Douala are contaminated with metals and that native earthworm species can bioaccumulate the studied metals at levels that could account for the toxic effects earlier recorded. With e-waste recycling growing worldwide, there is a need for more data, especially from understudied locations. Environ Toxicol Chem 2022;41:356–368. © 2021 SETAC
De Novo Assembly of the Nearly Complete Fathead Minnow Reference Genome Reveals a Repetitive but Compact Genome
Authors: Martinson John W. , Bencic David C. , Toth Gregory P. , Kostich Mitchell S. , Flick Robert W. , See Mary J. , Lattier David , Biales Adam D. , Huang Weichun 
Published: December 2021

Abstract
The fathead minnow is a widely used model organism in environmental toxicology. The lack of a high-quality fathead minnow reference genome, however, has severely hampered its uses in toxicogenomics. We present the de novo assembly and annotation of the fathead minnow genome using long PacBio reads, Bionano and Hi-C scaffolding data, and large RNA-sequencing data sets from different tissues and life stages. The new annotated fathead minnow reference genome has a scaffold N50 of 12.0 Mbp and a complete benchmarking universal single-copy orthologs score of 95.1%. The completeness of annotation for the new reference genome is comparable to that of the zebrafish GRCz11 reference genome. The fathead minnow genome, revealed to be highly repetitive and sharing extensive syntenic regions with the zebrafish genome, has a much more compact gene structure than the zebrafish genome. Particularly, comparative genomic analysis with zebrafish, mouse, and human showed that fathead minnow homologous genes are relatively conserved in exon regions but had strikingly shorter intron regions. The new fathead minnow reference genome and annotation data, publicly available from the National Center for Biotechnology Information and the University of California Santa Cruz genome browser, provides an essential resource for aquatic toxicogenomic studies in ecotoxicology and public health. Environ Toxicol Chem 2022;41:448–461. Published 2021. This article is a U.S. Government work and is in the public domain in the USA.
Abstract
The de novo assembly of the high-quality fathead minnow reference genome revealed the compact and repetitive genome of fathead minnow and its phylogenetic relationship with other model species.
Distributed data backup and recovery for software‐defined wide area network controllers
Authors: Zhang Yi , Zhong Lujie , Yang Shujie , Muntean Gabriel‐Miro 
Published: December 2021

AbstractSoftware‐defined wide area network (SD‐WAN) is a new type of network architecture that has developed rapidly in recent years. SD‐WAN inherits the centralized control architecture of software‐defined networking (SDN), but supports more diverse access methods and equipment types and covers a wider area. It is also associated with greater uncertainty in the network environment. These characteristics make the fault management of the SD‐WAN controller more challenging, so that the existing SDN‐based data backup methods cannot adapt to SD‐WAN scenarios. This article proposes an SD‐WAN‐oriented distributed data backup and recovery method (DDBR) based on an improved secret sharing algorithm. To deploy this method, we design an online‐offline dual backup framework based on the data freshness requirements of the controller. Under this framework, dynamic data of the controller is divided into different shares, and then stored into the storage of switches. When the controller fails, data recovery can be performed on the backup controller quickly, which greatly improves the network availability. The outstanding feature of the proposed DDBR method is that it ensures the integrity and confidentiality of the backup data in an unreliable network environment, even when some of the storage nodes fail. Theoretical analysis and evaluation results on file backup example show that the proposed solution has significant advantages over existing methods in terms of backup data storage size, communication overhead, backup and recovery success rate.
VPS35, the core component of the retromer complex, and Parkinson's disease
Authors: Luo Ai‐Di , Xu Zu‐Cai , Liao Shu‐Sheng 
Published: December 2021

AbstractParkinson's disease (PD) is a neurodegenerative disease that is common in middle‐aged and elderly people, and its onset is related to multiple factors, such as heredity, environment, and age. The vesicle protein sorting 35 (VPS35) gene was found to be a late‐onset autosomal dominant familial PD (PARK17) causative gene. The protein encoded by this gene is located in the endosome and aggregates with other membrane proteins to form a retromer complex, which participates in the membrane protein cycle between the endosome and the Golgi network. Increasing evidence shows that VPS35 may participate in the pathogenesis of PD by affecting autophagy, mitochondria, neurosynaptic transmission, dopamine signaling pathways, and so forth, and it can interact with other disease‐causing genes of familial PD. This article aimed to review the functions of VPS35 and the mechanism of its mutations in PD that have been discovered in recent years.
The promise and perils of regulating ipso facto clauses
Authors: Sarra Janis , Payne Jennifer , Madaus Stephan 
Published: December 2021

AbstractIt is common for contracts to include a clause that provides that on an event of default the counterparty has an unconditional right to terminate the contract or accelerate payment (an ipso facto clause). The regulation of ipso facto clauses has become a topic of debate in recent years with a number of jurisdictions introducing constraints on such clauses as part of broader restructuring reform packages. These jurisdictions include Germany in 2021 (as part of its implementation of the EU Restructuring Directive) and the United Kingdom in 2020. For jurisdictions introducing such constraints for the first time, there is much to learn from those, such as Canada, that have had constraints on ipso facto clauses in place for much longer. This article examines the experience in Canada alongside the constraints introduced in the United Kingdom, the EU Restructuring Directive and Germany, and identifies a series of steps that policymakers should follow when revising a regime on ipso facto clauses. Although there are a number of common themes that emerge, it is clear that different jurisdictions often make quite distinct policy choices regarding the rationale for any constraints on ipso facto clauses as well as on the specific nature and scope of the provisions. Different jurisdictions find different points of balance between the interests of individual creditors in upholding their freedom of contract and the rights of the debtor and creditors as a whole in preserving the business as a going concern. The range of choices is not per se problematic as long as they are implemented with clarity and transparency, so that debtors and creditors can bargain ex ante in the light of any legislative provisions.
Collaborative Digital Problem‐Solving: Power, Relationships, and Participation
Authors: Jacobs Gloria E. , Castek Jill 
Published: December 2021

AbstractThe study examines the collaborative nature of problem solving as dyads and triads of adults were grouped to solve digital problems using online resources. Digital problem solving involves the nimble use of skills, strategies, and mindsets to navigate online in everyday contexts using novel resources, tools, and interfaces, in efficient and flexible ways, to accomplish personal and professional goals. Findings address the nature of collaborative talk during digital problem solving through three interrelated categories of themes gleaned from discourse analysis: (a) power, (b) relationships, and (c) participation. These themes offer a nuanced understanding of collaborative interactions during digital problem solving. Implications from this research suggest ways to design collaborative activities and support dialogic interaction, whether among adolescents or adults, during online learning, in formal education settings or informally in other settings where collaboration occurs.
Banana peel derived biomass carbon: Multi‐walled carbon nanotube composite modified electrode for sensitive voltammetric detection of baicalein
Authors: Ai Yijing , Liu Juan , Yan Lijun , Li Guangjiu , Wang Xianghui , Sun Wei 
Published: December 2021

AbstractIn this study, a novel electrochemical sensor was developed for the detection of baicalein based on multi‐walled carbon nanotube (MWCNT) and banana peel derived biomass carbon (BPBC) composite modified glassy carbon electrode (GCE). The BPBC was synthesized by carbonization and alkali activation method using commonly available banana peel as the raw material, which was further mixed with MWCNT to obtain BPBC‐MWCNT composite. Then the composite modified GCE was fabricated and used for voltammetric detection of baicalein with a wide detection range from 0.0040 to 100.0 μM as well as a low detection limit of 1.33 nM (3σ/S). Also, the electrochemical behaviors of baicalein on BPBC‐MWCNT/GCE were investigated by cyclic voltammetry in detail. The proposed method was applied to the detection of baicalein content in Shuanghuanglian oral liquid with satisfactory results. Therefore, this work extended the electrochemical method for the drug analysis by using biomass‐derived carbon‐based composite.
Biosynthesis of silver nanoparticles using endophytic Fusarium oxysporum strain NFW16 and their in vitro antibacterial potential
Authors: Ilahi Nikhat , Haleem Abdul , Iqbal Sajid , Fatima Nighat , Sajjad Wasim , Sideeq Abubakar , Ahmed Safia 
Published: December 2021

AbstractNanotechnology has provided a platform for altering, modifying, and developing metal properties to nanoparticles with promising applications. This study aimed to produce functionalized and biocompatible silver nanoparticles (AgNPs) using cellular extracts of endophytic Fusarium oxysporum‐NFW16 isolated from Taxus fauna and evaluate its antibacterial potential. Under optimized reaction conditions, well‐dispersed and extremely stable AgNPs were synthesized in 1 hr. AgNPs were characterized through UV–visible spectrophotometry (at 423 nm), and scanning electron microscopy, energy dispersive X‐ray spectroscopy, X‐ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The obtained AgNPs were spherical, monodispersed, and size was ~30–36.1 nm. Strong peaks of XRD (311), (220), (200), and (111) matched to silver plane's diffraction facets. FTIR spectra at 1,650, 2,950, and 1,400 cm−1 confirmed the capping of AgNPs with phenolic compounds and compounds having primary amines. The AgNPs showed 100 μg/ml of minimum inhibitory concentration against methicillin‐resistant Staphylococcus aureus (MRSA). In addition, AgNPs showed a synergistic effect with both vancomycin and ciprofloxacin against MRSA (25%), Pseudomonas aeruginosa (50%), and pus isolated Escherichia coli (50%). Moreover, AgNPs impregnated cotton and bandage showed in vitro antibacterial potential against American Type Culture Collection and skin‐associated clinical pathogenic bacteria. Findings showed that endophytic fungi are the potential source for AgNPs synthesis that are effective against multidrug‐resistant bacteria and the development of antimicrobial textile finishes.
Analysis of the resilience strategies of Cameroonian companies in the face of Covid‐19 and their effects on activity
Authors: Fomba Kamga Benjamin , Nda'Chi Deffo Rodrigue 
Published: December 2021

AbstractThe aim of this study is to analyse the strategies adopted by enterprises in the face of Covid‐19 and to evaluate their impact on production. The data used are those of the rapid survey of enterprises on the evaluation of the socio‐economic effects of the coronavirus in Cameroon carried out by the National Institute of Statistics (INS). The recursive multivariate probit regression is used to account for the potential endogeneity between the different strategies adopted. The results show that there is a strong dependency in the adoption of the different strategies and this has a negative impact of 5% on the probability of maintaining the activity.
Sequential dynamics of virological and serological changes in the serum of SARS‐CoV‐2 infected patients
Authors: Ouoba Serge , Okimoto Mafumi , Nagashima Shintaro , Kitahara Yoshihiro , Miwata Kei , Ko Ko , E Bunthen , Sugiyama Aya , Takahashi Kazuaki , Sakaguchi Takemasa , Takafuta Toshiro , Tanaka Junko 
Published: December 2021

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) viral load dynamics in respiratory samples have been studied, but knowledge about changes in serial serum samples of infected patients in relation to their immunological response is lacking. We investigated the dynamics of SARS‐CoV‐2 viral load and antibody response in sequential serum of coronavirus disease 2019 (COVID‐19) patients and attempted to culture the virus in the serum. A total of 81 sequential serum samples from 10 confirmed COVID‐19 patients (5 with mild and 5 with moderate symptoms) were analyzed. Samples were collected during hospitalization and after discharge (median follow‐up of 35 days). SARS‐CoV‐2 ribonucleic acid in the serum was detected by real‐time polymerase chain reaction. Total antibody and IgG to SARS‐CoV‐2 Spike protein were analyzed by Chemiluminescent Immunoassays, and neutralizing antibodies were detected using a Surrogate Virus Neutralization Test. Viremia was observed in all cases at admission, and viral copy gradually dropped to undetectable levels in patients with mild symptoms but fluctuated and remained persistent in moderate cases. The viral culture of samples with the highest viral load for each patient did not show any cytopathic change. The antibody response was faster and higher in moderate cases. This study provides a basic clue for infectious severity‐dependent immune response, viremia, and antibody acquisition pattern.
Case presentation and panel discussion: Nutrition issues in cancer
Authors: Mundi Manpreet S. , Mechanick Jeffrey I. , Patel Jayshil J. , Laviano Alessandro , Martindale Robert G. , Zimmers Teresa A. 
Published: December 2021

AbstractAdvances in treatment of malignancy including novel pharmacologic therapies and surgical interventions has led to significant improvement in survival. As cancer becomes a chronic disease, nutrition interventions play an increasingly important role in short‐ and long‐term outcomes. The current manuscript presents a case of a 66‐year‐old male with new diagnosis of pancreatic cancer diagnosed incidentally in the setting of COVID‐19. Expert panelists in the field of nutrition discuss optimal strategies for diagnosis of malnutrition along with preoperative, perioperative, and postoperative optimization of nutrition. This discussion focuses on the use of probiotics, immune‐modulating nutrition, fish oil, specialized proresolving mediators, and use of enteral and parenteral nutrition support.
Synthesis, micellization and cytotoxic studies of ester‐functionalized imidazolium gemini surfactants
Authors: Mir Ab Waheed , Shaheen Arifa , Wani Mohammad Rafiq , Arif Rabia 
Published: December 2021

AbstractThe fatty acid‐based imidazolium gemini surfactants containing hydroxy‐substituted spacers were synthesized and characterized by different spectral techniques. The micellization behavior of product compounds was studied by determining their critical micelle concentration (cmc) values from steady state fluorescence and conductivity measurements. The thermodynamic parameters of micellization of synthesized gemini surfactants confirmed that the micelle formation is a thermodynamically favorable, endothermic and an entropy driven phenomenon. The surfactants were further analyzed for their cytotoxic nature by treating them upon human embryonic kidney cell (HEK‐293) line and were found to be significantly low cytotoxic. The interesting features like low cmc values, non‐cytotoxic and eco‐friendly nature of the gemini surfactants may offer new and more efficient substitutes to the conventional drug delivery systems. Thus the gemini surfactants may serve as promising candidates in the biomedical and pharmaceutical fields.