bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLVCR1 Predicts Poor Prognosis and Promotes Malignant Phenotype in Esophageal Squamous Cell Carcinoma via Upregulating CSE1L
Authors: Zhou Suna , Zhang Mingxin , Zhou Chao , Meng Yinnan , Yang Haihua , Ye Wenguang 
Published: March 2021

ObjectiveDysregulation of feline leukemia virus subgroup C receptor 1(FLVCR1) expression has been investigated in several tumors. However, the expression and role of FLVCR1 in esophageal squamous cell carcinoma (ESCC) remain largely unknown.MethodsFLVCR1 expression in tissues was measured by immunohistochemical staining (IHC). Celigo assay, MTT assay, colony formation, caspase 3/7 activity analysis, wound healing assay, Transwell migration, and invasion assay were applied to assess the effects of FLVCR1 on ESCC tumorigenesis. Coimmunoprecipitation (Co-IP) and liquid chromatography-mass spectrometry (LC-MS) were used to identify protein interactions with FLVCR1. An in vivo imaging system (IVIS) was used to investigate the functions of FLVCR1 on the growth and metastatic capability of ESCC cells in a xenograft model and a tail vein metastasis model.ResultsElevated expression of FLVCR1 was detected in ESCC tissues and predicted poor survival. Upregulated FLVCR1 was positively correlated with lymph node metastasis (N stage) and late tumor-node-metastasis (TNM) stage. FLVCR1 knockdown inhibited cell proliferation and colony formation ability, induced cell apoptosis, and repressed cell migration and invasion of ESCC in vitro. Inhibition of FLVCR1 markedly repressed tumorigenicity and metastasis of ESCC cells in vivo. Mechanistically, chromosome segregation 1–like (CSE1L) was identified to interact with FLVCR1 using a Co-IP assay. Moreover, the inhibitory effect of FLVCR1 knockdown on proliferation and migration was counteracted by the exogenous expression of CSE1L.ConclusionFLVCR1 plays a pivotal role in ESCC cell survival, growth, and migration. These functions may be partially dependent upon the protein interaction between FLVCR1 and CSE1L. In addition, FLVCR1 can be applied as a clinical prognostic marker for patients with ESCC.
CircRNA circ_0092314 Induces Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells via Elevating the Expression of S100P by Sponging miR-671
Authors: Shen Qian , Zheng Gang , Zhou Yi , Tong Jin , Xu Sanpeng , Gao Hui , Zhang Xiaofan , Fu Qiang 
Published: March 2021

BackgroundCircular RNAs (circRNAs) is a novel class of non-coding RNAs that regulate gene expression during cancer progression. Circ_0092314 is a newly discovered circRNA that was upregulated in pancreatic cancer (PAAD) tissues. However, the detailed functions and underlying mechanisms of circ_0092314 in PAAD cells remain unclear.MethodsWe first determined the expression of circ_0092314 in PAAD and normal tissues and further investigated the functional roles of circ_0092314 in regulating epithelial-mesenchymal transition (EMT) of PAAD cells. We also assessed the regulatory action of circ_0092314 on the microRNA-671 (miR-671) and its target S100P.ResultsCirc_0092314 was markedly upregulated in PAAD tissues and cells, and its overexpression was closely correlated with worse prognosis of PAAD patients. Functionally, circ_0092314 promotes proliferation, invasion and EMT in vitro and tumor growth in vivo. Mechanistically, we demonstrated that circ_0092314 directly binds to miR-671 and relieve its suppression of the downstream target S100P, which induces EMT and activates the AKT signaling pathway. The tumor-promoting effects caused by overexpression of circ_0092314 could be revered by re-expression of miR-671 in PAAD cells.ConclusionsOverall, our study demonstrates that circ_0092314 exerts critical roles in promoting the EMT features of PAAD cells, and provides insight into how elevated expression of circ_0092314 might influence PAAD progression.
Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis
Authors: Ren Yu , Wang Xue , Huang Shuaishuai , Xu Yangkai , Weng Guobin , Yu Rui 
Published: March 2021

Purpose: Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL), a member of the TNF family, can selectively induce cancer cell death while sparing normal cells. However, the application of TRAIL-based antitumor therapies has been hindered due to drug resistance. Alternol is a new compound isolated from microbial fermentation that possesses antitumor activity in different tumors. In our research, we discovered that alternol can sensitize TRAIL-induced apoptosis in renal carcinoma cells (RCCs).Materials and Methods: Cytotoxic activity was measured by MTT assay. Apoptosis was probed using the PI/annexin V method. Real-time PCR and western blot were used to test the levels of mRNA and protein, respectively. Luciferase assay was used to investigate whether CHOP regulated the expression of death receptor (DR) 5 through transcription. A xenogeneic tumor transplantation model was used to evaluate the anticancer effects of alternol/TRAIL in vivo.Results: When the mechanisms were investigated, we discovered that alternol increased DR5 expression. DR5 knockdown by siRNA eliminated the enhanced effect of alternol on TRAIL-mediated apoptosis. Alternol reduced the expression of antiapoptotic proteins and increased the levels of proapoptotic proteins. Moreover, alternol increased the level of CHOP, which is necessary for the enhancing effect of alternol on TRAIL-induced apoptosis, given that downregulation of CHOP abrogated the synergistic effect. DR5 upregulation induced by alternol required the production of reactive oxygen species (ROS). Removing ROS inhibited the induction of DR5 and blocked the antiapoptotic proteins induced by alternol.Conclusion: Taken together, our research suggested that alternol increased TRAIL-mediated apoptosis via inhibiting antiapoptotic proteins and upregulating DR5 levels via ROS generation and the CHOP pathway.
Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness
Authors: Kettner H. , Rosas F. E. , Timmermann C. , Kärtner L. , Carhart-Harris R. L. , Roseman L. 
Published: March 2021

Background:Recent years have seen a resurgence of research on the potential of psychedelic substances to treat addictive and mood disorders. Historically and contemporarily, psychedelic studies have emphasized the importance of contextual elements ('set and setting') in modulating acute drug effects, and ultimately, influencing long-term outcomes. Nevertheless, current small-scale clinical and laboratory studies have tended to bypass a ubiquitous contextual feature of naturalistic psychedelic use: its social dimension. This study introduces and psychometrically validates an adaptedCommunitas Scale,assessing acute relational experiences of perceived togetherness and shared humanity, in order to investigate psychosocial mechanisms pertinent to psychedelic ceremonies and retreats.Methods:In this observational, web-based survey study, participants (N= 886) were measured across five successive time-points: 2 weeks before, hours before, and the day after a psychedelic ceremony; as well as the day after, and 4 weeks after leaving the ceremony location. Demographics, psychological traits and state variables were assessed pre-ceremony, in addition to changes in psychological wellbeing and social connectedness from before to after the retreat, as primary outcomes. Using correlational and multiple regression (path) analyses, predictive relationships between psychosocial 'set and setting' variables, communitas, and long-term outcomes were explored.Results:The adapted Communitas Scale demonstrated substantial internal consistency (Cronbach's alpha = 0.92) and construct validity in comparison with validated measures of intra-subjective (visual, mystical, challenging experiences questionnaires) and inter-subjective (perceived emotional synchrony, identity fusion) experiences. Furthermore, communitas during ceremony was significantly correlated with increases in psychological wellbeing (r= 0.22), social connectedness (r= 0.25), and other salient mental health outcomes. Path analyses revealed that the effect of ceremony-communitas on long-term outcomes was fully mediated by communitas experienced in reference to the retreat overall, and that the extent of personal sharing or ‘self-disclosure’ contributed to this process. A positive relationship between participants and facilitators, and the perceived impact of emotional support, facilitated the emergence of communitas.Conclusion:Highlighting the importance of intersubjective experience, rapport, and emotional support for long-term outcomes of psychedelic use, this first quantitative examination of psychosocial factors in guided psychedelic settings is a significant step toward evidence-based benefit-maximization guidelines for collective psychedelic use.
No Evidence for a Decrease in Physical Activity Among Swiss Office Workers During COVID-19: A Longitudinal Study
Authors: Aegerter Andrea Martina , Deforth Manja , Sjøgaard Gisela , Johnston Venerina , Volken Thomas , Luomajoki Hannu , Dratva Julia , Dressel Holger , Distler Oliver , Melloh Markus , Elfering Achim ,   the NEXpro Collaboration Group
Published: March 2021

PurposeThe COVID-19 lockdown interrupted normal daily activities, which may have led to an increase in sedentary behavior (Castelnuovo et al., 2020). The aim of this study was to investigate the effect of the COVID-19 pandemic on the level of physical activity among Swiss office workers.MethodsOffice workers from two Swiss organizations, aged 18–65 years, were included. Baseline data from January 2020 before the COVID-19 pandemic became effective in Switzerland were compared with follow-up data during the lockdown phase in April 2020. Levels of physical activity were assessed using the International Physical Activity Questionnaire. Paired sample t-tests or Wilcoxon signed-rank test were performed for statistical analysis.ResultsData from 76 participants were analyzed. Fifty-four participants were female (71.1%). The mean age was 42.7 years (range from 21.8 to 62.7) at baseline. About 75% of the participants met the recommendations on minimal physical activity, both before the COVID-19 pandemic and during the lockdown. Weak statistical evidence for a decline in total physical activity in metabolic equivalent of task minutes per week (MET min/week) was found (estimate = −292, 95% CI from – ∞ to 74, p-value = 0.09), with no evidence for a decrease in the three types of activity: walking (estimate = −189, 95% CI from – ∞ to 100, p-value = 0.28), moderate-intensity activity (estimate = −200, 95% CI from – ∞ to 30, p-value = 0.22) and vigorous-intensity activity (estimate = 80, 95% CI from – ∞ to 460, p-value = 0.74). Across the three categories “high,” “moderate,” and “low” physical activity, 17% of the participants became less active during the lockdown while 29% became more active.ConclusionThe COVID-19 pandemic did not result in a reduction in total physical activity levels among a sample of Swiss office workers during the first weeks of lockdown. Improved work-life balance and working times may have contributed to this finding.Clinical Trial Registrationwww.ClinicalTrials.gov, NCT04169646. Registered 15 November 2019 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04169646.
Health Patterns Reveal Interdependent Needs of Dutch Homeless Service Users
Authors: Everdingen Coline van , Peerenboom Peter Bob , Velden Koos van der , Delespaul Philippe 
Published: March 2021

Background: Homelessness is an increasing problem in Western European countries. Dutch local authorities initiated cross-sectional reviews to obtain accurate health and needs information on Homeless Service (HS) users.Methods: The Homeless People Treatment and Recovery (HOP-TR) study uses a comprehensive assessment strategy to obtain health data. Using a naturalistic meta-snowball sampling in 2015–2017, 436 Dutch HS users were assessed. The lived experience of HS users was the primary data source and was enriched with professional assessments. The InterRAI Community Mental Health questionnaire and “Homelessness Supplement” provided information in different areas of life. The approach for mental health assessments was transdiagnostic. Raw interview data were recoded to assess health and needs. The positive health framework structured symptomatic, social, and personal health domains relevant to recovery.Results: Most subjects were males, low educated, with a migration background. The majority were long-term or intermittently homeless. Concurrent health problems were present in two domains or more in most (95.0%) subjects. Almost all participants showed mental health problems (98.6%); for a significant share severe (72.5%). Frequent comorbid conditions were addiction (78%), chronic physical conditions (59.2%), and intellectual impairments (39.9%).Conclusion: The HOP-TR study reveals significant concurrent health problems among Dutch HS users. The interdependent character of different needs requires an integrated 3-D public health approach to comprehensively serve symptomatic, social, and personal dimensions, required to facilitate recovery.
Emission wavelength control of InAs/GaAs quantum dots using an As2 source for near-infrared broadband light source applications
Authors: Ozaki Nobuhiko , Hayashi Yuma , Ohkouchi Shunsuke , Ohsato Hirotaka , Watanabe Eiichiro , Ikeda Naoki , Sugimoto Yoshimasa , Hogg Richard A. 
Published: March 2021

Abstract
Herein, we report an emission wavelength control technique for self-assembled InAs quantum dots (QDs) grown via molecular beam epitaxy using an As2 source (As2-QDs). The As2-QDs exhibited photoluminescence with a shorter center wavelength and larger bandwidth than those of the QDs grown using an As4 source. In addition, the emission center wavelength could be controlled by adjusting the time between the growth and capping of the As2-QDs. We utilized the multilayer stack of emission-wavelength-controlled As2-QDs to fabricate an electrically-driven light source and demonstrated its broadband (approximately 130 nm) emission in the 1–1.3 μm wavelength range.
Generation of a 59 fs pulse with a 550 nm spectral range in a mode-locked Er-doped single-mode fiber laser system
Authors: Lin Qimeng , Yan Li , Song Yuanqi , Jia Xuzhuo , Feng Xiaoqiang , Hou Lei , Bai Jintao 
Published: March 2021

Abstract
We demonstrated a compact broad spectrum ultrashort fiber laser system that employed a similariton laser as a seed and fiber-optic nonlinearities in an erbium-doped fiber amplifier to broaden the optical spectrum. The system generated a stable 59 fs ultrashort pulse with a spectral bandwidth beyond 550 nm (i.e. 1490–2030 nm). The mode-locked oscillator produced an 85.9 fs similariton pulse at the wavelength of 1553 nm. The maximum average output power of the laser system was 251 mW. This new type of standard single-mode fiber-format energetic ultrashort system was suitable as a source for biological tissue imaging, broad-band spectroscopy, and optical frequency combs.
The Genealogy of a Collection: Working with Manuscript Library Catalogues
Authors: Weis Joëlle 
Published: March 2021

In 1773 Gotthold Ephraim Lessing, at that time librarian of the ducal library in Wolfenbüttel, criticised his predecessors of only being interested in the history of the library’s augmentation, of the library’s „genealogy“. According to the famous writer, former librarians were so fixated on the catalogues that they forgot the real purpose of telling a collection’s history: showing how it contributed to scholarship. Of course, Lessing has a point, the history of a collection and its holding institution should not be told simply by enumerating objects, but he might have underestimated the potential of catalogues and book lists as sources for the history of scholarship, indeed the history of knowledge. Library catalogues should not only be seen as valuable sources for the reconstruction of an as-is state of the library at a specific moment of the collection’s life but that a much broader perspective can be taken. Using the example of the Wolfenbüttel manuscript catalogues dating from the mid-17th to the 18th century, the catalogues can be read as behavioural guidelines, as an instrument for representation, as a witness for scholarly practices or as legal papers. Just as for literary documents, they invite to read between the lines, to analyse their specific style as well as to discover the different communicative strategies and hidden messages. Using Lessing’s image, the catalogues help with the composition of an enhanced genealogy, positioning every item into a network of objects, texts, practices, and ideas.
Dampak Covid 19 Bagi Perekonomian Indonesia
Authors: Fahmi Abdullah  
Published: March 2021

Covid 19 merupakan virus yang berasal dari Wuhan, China dan sekarang menjadi pandemic global, efek yang terjadi dengan adanya covid 19 sangat dahsyat, virus ini tidak hanya menyerang kesehatan manusia saja, namun juga menyerang kondisi ekonomi dunia, rumusan masalah penelitian ini adalah: Apakah ada perbedaan saham IHSG sebelum dan sesudah covid 19?, Apakah ada perbedaan kurs mata uang Rupiah terhadap Dollar Amerika sebelum dan sesudah covid 19?, Bagaimana inflasi Indonesia pada saat covid 19?. Dalam penelitian ini tekhnik pengambilan sampel menggunakan sampel non probability sampling dengan menggunakan sampling purposive atau tekkhnik pengambilan sampel dengan menggunakan pertimbangan tertentu Hasil penelitian ini menunjukkan Terdapat perbedaan signifikan pergerakan saham IHSG sebelum dan sesudah covid 19, dan secara rata-rata ada penurunan saham IHSG sebelum menu sesudah covid 19, Terdapat perbedaan signifikan pergerakan kurs mata uang Dollar Amerika Serikat terhadap Rupiah, dan secara rata-rata terjadi penurunan nilai Rupiah terhadap Dollar Amerika Serikat dari sebelum menuju sesudah covid 19, danAdanya penurunan Inflasi secara rata-rata dari sebelum adanya covid menuju sesudah adanya pandemic covid 19.
Iraqi Contemporary Language of Poetry: Nineties as a Model
Authors: Walie Fattah Assist. Prof. D. Yahia , Lazem Dr. Alaa Muhammad 
Published: March 2021

Poetic language is the only a movement based mostly on the stereotypes and pugnacity what is prevalent in the language communicative by eluding and escape from him towards the level of performance of works on raising the effectiveness of the speech and poetic Anashha a lot of surprises and variations in say poetic ; So whatever ventured poet order behind the new technology , no matter what type of Ajthadath performance , the poem remains a creative effort embodied in the language first , and which seeks to demonstrate the usefulness and vitality of a second. The turnaround grand poem nineties embodied in it restored the poem to the Kingdom of hair after that has been lost in the paths of formality purely by Althmanyen dropping more open to the lattice actually fashionable and idler margin after it abandoned tower (Teleological language) and (the absence of meaning), which characterized them poem eighties .This study aims to identify the most prominent benchmarks key that is characterized by the language of poetry Altsaina level compositional and visibility and detection charms aesthetic embodied in Artaadha new areas mission did not pay attention to it before and did not mean the Iraqi poet previously as not involving any poetry by perspective poetic traditional.
Textual Culturing in Ibn Al-Labana Al-Dany’s Poetry (527 B.C -1113A.D)
Authors: Al-Husoona Assist.Prof. Hussein Mageed Rustam 
Published: March 2021

Text Blog verbal happen in time and place certain goal to communicate and Interestingness impact and transfer the experiences of others and Mkamenhm emotional can be configured Bamolq and cloning closed by lock called biblical iconography Her beginning and the end, and generative because it is not pop out of nowhere or Nabta diabolical but it is a-generated events that breed with other events .Any text that is born through conversion Semantic any. Conversion guide one to several signs and vice versa, which is linked to the productive capacity of the text Vigdo so the scene of Toldat of images and different patterns of significance, is born president has, and the march Altdalal. is defined by the nature of its relations with the virtual and hidden with other texts that are involved in creating the text as ((integrated organization drafting a complex tangle of installation it is a network of overlapping diets and levels of editorial and systemic involves numbering glitter ... and realize the multiplicity of the same meaning)).
A Linguistic Study of Ibn-Khaldoon’s Introduction: A Procedural Study in the Light of (Folklore Linguistics Project)
Authors: Al-Tae Dr. Niama Dahash Farhan 
Published: March 2021

The linguistic theory of heritage has adopted the ancient Arabic linguistic Folklore as a subject for various studies on the basis of the principles of rereading, which is characterized by multi-purposes like briefing ancient linguistic perceptions and interpreting them in accordance with the new trends of linguistic research in a way to equalize the ancient linguistic thought results. The new trends in linguistic theories have a new view to identify its historical and civilized value according to the new type of a new reading to have it been as an intellectual attitude by itself. As the linguistic subjects involve certain purposes, this study aims at finding out the closeness and similarity between the Arabic linguistic folklore and the new trends in linguistics. To be tackled with in our Arabic folklore is what Ibn-Khaldoon left, which is used to be distinguished and pre his era, regarding applied linguistic similarities. His remarks extended to theoretical linguistic issues related to Arabic, in particular. He talked about language and linguistics ; their concepts and natures, tackled with the issue of linguistic development and the functions of parsing regarding its nature as far as form and function concerned. He indicated rhetoric and eloquence and deeply showed the relation between language and society. Such nature and its earlier effect of what we call linguistic variation , or to put it more precisely, it was as an attempt to explore the extent of equivalence between the linguistic structure and socio-psycho structures which used to be as the basic foundation of applied linguistics; therefore, these similarities have been demonstrated in two sections:
1 - Psycholinguistic similarities according to Ibn-Khaldoon.
2 - Sociolinguistic similarity according to Ibn-Khaldoon.
An Analytical Study of Errors made during Learning Second Language
Authors: R. Eesa Lecturer  Mayada , S.Danial Lecturer:Luma 
Published: March 2021

Error Analysis can be considered as a type of linguistic analysis that focuses on the errors learners make. It consists of a comparison between the errors made in the target language and that target language itself. Many scholars in the field of Error Analysis have emphasized the significance of second language.Corder (1967:161) ,for example, in one of his articles , says that ''they are significant in three different ways .He starts with the teacher in that they show how far towards the goal the learner has progressed. Second , they provide to the researcher evidence of how a language is acquired , what strategies the learners is employing in his learning of a language .Thirdly , they are indisputable to the learner himself because we can regard the making of errors as a device the learner uses in order to learn''. The present paper mostly illustrates fundamental background studies done in the field of Error Analysis. There is a hope that the present work helps EFL teachers and educators to become familiar with the most frequent errors made by EFL learners leading them to make more objective decisions about how to go about adapting a appropriate teaching strategies to help EFL student learn better