bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical expression of ErbB/HER family proteins in patients with vulvar cancer
Authors: Baiocchi Glauco , de Freitas Rosyane Rena , Bovolim Graziele , Badiglian‐Filho Levon , da Costa Alexandre Andre Balieiro Anastacio , De Brot Louise 
Published: July 2021

AbstractObjectiveTo investigate the immunohistochemical (IHC) expression of the ErbB/HER family in primary vulvar squamous cell carcinoma (VSCC).MethodsWe analyzed a series of 125 patients who were surgically treated for VSCC from January 1980 to June 2016. All cases had lymph node (LN) staging and 80 had LN metastasis. A tissue microarray was built for epidermal growth factor receptor (EGFR), HER2, HER3, and HER4 IHC staining.ResultsIn the primary tumor we found positive expressions for EGFR, HER2, HER3, and HER4 in 5%, 0.9%, 0.9%, and 22.8%, respectively. For the LN metastasis, expressions of EGFR and HER4 were positive in 22.2% and 39.1%, respectively. No cases had positive staining for HER2 and HER3 in the LN metastasis. For HER4, positive expression correlated with smaller tumor sizes (P = 0.02). However, positive HER4 was related to adverse prognostic factors such as: histological grade (P = 0.012), presence of lymphovascular space invasion (40.9% vs 16.2%; P = 0.035), and perineural invasion (57.1% vs 16.7%; P = 0.006). Notably, all cases with LN metastasis had positive HER4 in the primary tumor (P < 0.001). ErbB/HER family expression was not related to worse survival.ConclusionEGFR, HER2, and HER3 were infrequently expressed in VSCC by IHC. HER4 IHC expression was found in 22.8% of cases and was related to adverse prognostic factors.
Simulation and optimal control for a long‐distance water diversion project under different rainfall types: A case study in the Middle Route of China's South‐to‐North Water Diversion Project*
Authors: Qiao Yu , Li Jiahong , Cui Wei , Long Yan , Lei Xiaohui 
Published: July 2021

AbstractRainfall and rainstorms pose potential risks and significant threats to open‐channel water diversion projects. In long‐distance water diversion projects, it is difficult to observe the hydraulic response through measured data directly and comprehensively. Without accurate hydraulic responses and advanced control strategies for the different rainfall types, operators or decision‐makers are unable to respond effectively to hydraulic changes in the case of sudden occurrences of rainfall or rainstorms. In this study, a simulation and optimal control model focusing on solving the Saint Venant equation based on the computational finite difference method and the combined particle swarm optimization algorithm, was established and applied to a long‐distance water diversion project, namely the Middle Route of the South‐to‐North Water Diversion Project, China, to analyse the hydraulic response and control the disturbance of various rainfall types. The simulation model was validated based on the calculation results, indicating that the simulation model yielded a relatively high precision with an error margin of 2.5%. The optimal control model can effectively reduce the maximum increase in water level caused by the different rainfall types in the range of 0.10–0.20 m.
The influence of social media usage on the DuPont method of analysis
Authors: Jeppson Nathan H. , Ruddy John A. , Salerno David F. 
Published: July 2021

AbstractIn this study, we provide new evidence regarding return on equity and its components for firms recognized for their effective use of social media compared to firms that use social media to a lesser extent. Using the Russell 3000 firms, we compare firms’ return on equity and sub components using difference in means tests and regression analysis. We find that firms recognized for their effective use of social media generate higher return on equity than other firms. Furthermore, when testing the disaggregation components, we find that the increased return on equity exhibited by firms using social media effectively is due to higher asset turnover and lower interest burden. We also find that such firms experience a higher tax burden.
The ultrasound‐guided attenuation parameter is useful in quantification of hepatic steatosis in non‐alcoholic fatty liver disease
Authors: Ogino Yu , Wakui Noritaka , Nagai Hidenari , Igarashi Yoshinori 
Published: July 2021

AbstractAimTo determine the utility of the ultrasound‐guided attenuation parameter (UGAP) for quantifying hepatic steatosis in non‐alcoholic fatty liver disease (NAFLD).MethodsSubjects were 84 patients with NAFLD (53 men, 31 women; mean age 54 [20–81] years) who underwent liver biopsy and ultrasonography using a GE LOGIQ E9 system and C1‐6 probe at our hospital between 2017 and 2020. B‐Mode imaging of segment V in the liver was acquired and echo attenuation was assessed using UGAP. Steatosis score (S0: <5%; S1: 5%–33%; S2: 34%–66%; S3: ≥67%) from liver specimens was compared with the attenuation coefficient (AC; dB/cm/MHz) using UGAP.ResultsSteatosis score was S0 for 9 patients, S1 for 40, S2 for 21, and S3 for 14. AC by steatosis score was 0.52 ± 0.07, 0.63 ± 0.07, 0.74 ± 0.06, and 0.78 ± 0.06 dB/cm/MHz for S0, S1, S2, and S3, respectively. AC by UGAP differed significantly between S0 and S1, S0 and S2, S0 and S3, S1 and S2, and S1 and S3 (all P < 0.01), demonstrating a significant increase with steatosis score. Receiver operating characteristic analysis showed good diagnostic performance of UGAP for patients with steatosis score ≥1, ≥2, and ≥3 (AUROC = 0.94, 0.95, and 0.88, respectively). Liver fat content (%) from liver specimens and AC (r = 0.81, P < 0.01) showed a significant positive correlation.ConclusionUGAP is useful for quantifying hepatic steatosis in patients with NAFLD.
Health‐related quality of life in Norwegian adults with Fabry disease: Disease severity, pain, fatigue and psychological distress
Authors: Pihlstrøm Hege Kampen , Weedon‐Fekjær Mina Susanne , Bjerkely Birgitte Leisner , von der Lippe Charlotte , Ørstavik Kristin , Mathisen Per , Heimdal Ketil , Jenssen Trond Geir , Dahle Dag Olav , Solberg Olga Karin , Sigurdardottir Solrun 
Published: July 2021

AbstractHealth‐related quality of life (HRQOL) is reduced in Fabry disease (FD) and associated with clinical disease manifestations, but few have used Fabry‐specific severity scores to study how disease burden interferes with quality of life. We investigated how the Fabry DS3, consisting of four somatic domains and one patient‐reported item, associates with HRQOL, while also evaluating fatigue, pain and psychological distress as possible predictors. Thirty‐six adults with FD completed the Short‐form Health Survey (SF‐36), the hospital anxiety and depression scale (HADS), the brief pain inventory (BPI) and reported fatigue on a visual analog scale. Clinical data were collected from the last multidisciplinary hospital visit. Using correlation and hierarchical linear regression analyses, we examined associations between demographic, clinical and self‐reported predictors and the SF‐36 physical (PCS) and mental (MCS) component summary scores. Males scored lower than the general population in all SF‐36 domains (P < .05). General health and social functioning were reduced in females. Before including self‐reported symptom scores, DS3 showed associations with PCS (P = .009). Our fully adjusted model explained 66% of the variation in PCS, where education (P = .040) and fatigue (P = .002) retained significance. With HADS depression score (P = .001) as the sole significant factor, our regression model explained 56% of the variation in MCS. The DS3 score has implications for HRQOL in FD. Low education and fatigue represent major barriers to physical well‐being, while depression strongly influences mental quality of life. Fatigue should be recognized as an important endpoint in future FD trials. Increased efforts to diagnose and treat affective disorders are warranted.
Going against the grain: The role of skilled migrants' self‐regulation in finding quality employment
Authors: Zikic Jelena , Klehe Ute‐Christine 
Published: July 2021

SummarySkilled migrants constitute a significant and growing population in our knowledge economy, as they self‐initiate international careers in search of permanent resettlement. Yet, once in the new country, many skilled migrants face dire disappointments in that the jobs offered to them often fall short of their training and aspirations. The current quantitative study combines existing insights from qualitative migration research on the barriers to quality employment with self‐regulation research during job search. We identify mechanisms by which migrants may proactively self‐regulate towards better employment quality. Among 356 skilled migrants in Canada, migration‐specific barriers (a perceived lack of language proficiency and credential recognition) weakened migrants' self‐regulation efforts in the form of career‐related exploration (goal establishment) and planning (goal planning). Migrants' proactivity and social support received fostered self‐regulation, however. Career planning, albeit not career exploration, significantly predicted migrants' quality of employment 9 months later, particularly when combined with a high level of credential recognition. Results are relevant for the limited literature on skilled migrants' transition into the new labor market, the study of self‐regulation in challenging career contexts, and the prevention of unsatisfactory employment.
Clinical outcomes of patients with endometrioid epithelial ovarian cancer following surgical treatment
Authors: Cybulska Paulina , Tseng Jill , Zhou Qin C. , Iasonos Alexia , Delair Deborah F. , Mueller Jennifer J. , Long Roche Kara C. , Abu‐Rustum Nadeem R. , Leitao Mario M. 
Published: July 2021

AbstractBackgroundEndometrioid epithelial ovarian cancer (EEOC) is rare, and its management poorly defined. We examined factors associated with 5‐year progression‐free survival (PFS) after surgery for EEOC.MethodsRetrospective study: treatment and outcomes of all EEOC patients undergoing initial surgery at, or presenting to, our institution within 3 months of initial surgery, 1/2002‐9/2017.ResultsIn total, 212 patients were identified. Median follow‐up, 63.9 months (range, 0.7–192); median age at diagnosis, 52 years (range, 20–88); disease stage: I, n = 145 (68%); II, n = 47 (22%); III/IV, n = 20 (9%); FIGO grade: 1, 127 (60%); 2, 66 (31%); 3, 17 (8%); unknown, 2 (1%). One hundred twenty‐eight (60%) had endometriosis; 75 (35%), synchronous endometrioid endometrial cancer (80%, IA); 101 (48%), complete surgical staging; 8 (5%), positive pelvic lymph nodes (LNs); 6 (4%), positive para‐aortic LNs; 176 (97%), complete gross resection; 123 (60%), postoperative chemotherapy; 56(28%), no additional treatment. Five‐year PFS, 83% (95% confidence interval [CI]: 76.6%–87.8%); 5‐year overall survival (OS), 92.7% (95% CI: 87.7%–95.8%). Age, stage, and surgical staging were associated with improved 5‐year PFS, and younger age at diagnosis with improved 5‐year OS (p < 0.001). Chemotherapy did not improve 5‐year PFS in IA/IB versus observation, but improved survival in IC (hazard ratio [HR]: 1.01, 95% CI: 0.22–4.59, p = 0.99; HR: 0.17, 95% CI: 0.04–0.7, p = 0.006).ConclusionsAge, stage, and full surgical staging were associated with improved 5‐year PFS. Chemotherapy showed no benefit in IA/IB disease.
Determination and analysis of monosaccharides in Polygonatum cyrtonema Hua polysaccharides from different areas by ultra‐high‐performance liquid chromatography quadrupole trap tandem mass spectrometry
Authors: Hu Jiayi , Cheng He , Xu Jun , Liu Junlin , Xing Lihua , Shi Suying , Wang Rui , Wu Zhendong , Yu Nianjun , Peng Daiyin 
Published: July 2021

AbstractWe wanted to explore a new method for the determination of monosaccharides in Polygonatum cyrtonema Hua polysaccharide using the ultra‐high‐performance liquid chromatography quadrupole trap tandem mass spectrometry. In this study, hydrochloric acid was used instead of trifluoroacetic acid to hydrolyze polysaccharides, and hydrolysis time was greatly reduced from 5–9 h to 1 h. The 1‐phenyl‐3‐methyl‐5‐pyrazolone was used for pre‐column derivatization of monosaccharides. The parameters of linearity (R2 > 0.999), stability (1.63–2.52%), intra‐day and inter‐day precision (0.69–0.95%, 1.81–2.77%), repeatability (1.89–2.65%), and recovery (97.63–102.24%) of the method were verified. Satisfactory validation results showed this method could be used to determine the target components. The results indicated the polysaccharide contained glucose, mannose, rhamnose, galactose, ribose, and arabinose. Technique for order preference by similarity to an ideal solution and principal component analysis were used to build an evaluation model based on the monosaccharide composition. The evaluation results showed that the samples from the Qingyang County of Anhui Province were the best when the monosaccharides were used as the evaluation index. Therefore, a new method was established to detect the monosaccharide content of polysaccharides from Polygonatum cyrtonema Hua and comprehensively evaluate the quality of Chinese medicines with polysaccharides as the main active ingredient.
Film Blowing of Biodegradable Polymer Nanocomposites for Agricultural Applications
Authors: Mistretta Maria Chiara , Botta Luigi , La Mantia Francesco Paolo , Di Fiore Antonino , Cascone Marco 
Published: July 2021

AbstractFilms for agricultural applications, such as greenhouses films or mulching films are generally made of polyolefins such as linear low‐density polyethylene (LLDPE) or low‐density polyethylene. However, the use of biodegradable and/or compostable polymers is increasing, which enjoy the additional advantage that they can be left on the site since a fine life would be gradually assimilated to the underlying soil. Nevertheless, biodegradable polymeric films often do not have suitable mechanical performances. In this work, biodegradable polymer‐based nanocomposite films are prepared by film blowing and compared with traditional LLDPE based nanocomposites. In particular, a biodegradable polymer blend and two different inorganic nanofillers (an organo‐modified clay and a calcium carbonate with a hydrophobic coating) are used for the preparation of the nanocomposites. A detailed investigation of obtained materials is performed through rheological, mechanical, and optical characterizations. Adding nanofillers led to an increase of rigidity and tear strength of blown films without negatively affecting their ductility.
Microstructure and compressive properties of Al‐Si10‐Mg lattice structures manufactured using selective laser melting
Authors: Huo P.C. , Zhao Z.Y. , Bai P.K. , Du W.B. , Zhao R.X. , Zhang L.Z. , Wang Q. , Wu L.Y. , Han B. , Han J.N. , Tie D. 
Published: July 2021

AbstractIn this study, the aluminum alloy lattice structure was processed using selective laser melting, and the compressive behaviour was studied. When the porous aluminum alloy was compressed along the building direction, the compressive stress initially increased, followed by a decrease, and then another increase. The aluminum alloy lattice structure mainly underwent the stages of elasticity, shearing, collapse, and then densification in the course of the compression process; the fracture primarily occurred at the joints of the pillars and the support plates. Moreover, the fractures of the aluminum alloy lattice structure, as prepared by selective laser melting, exhibited dimples of different sizes and shapes. The silicon content at the bottom of such a dimple was higher than that at the edges. When the stress level reached its limit and was insufficient to coordinate the plastic deformation of the two phases (α‐aluminum / silicon interface), micro‐pores formed at the interface (the dimples resulted from the breakage of numerous micro‐pores after aggregation), which caused the silicon content at the bottom of the dimple to be higher than that at the edge.
Finite element analysis on shape deformation of the macro‐structure region during hot‐rolling process for gear steel FAS3420H and its modification
Authors: Liu S. , Wang F.M. , Li C.R. 
Published: July 2021

AbstractThe rectangular macro‐segregation region in the core of hot‐rolled steel bar has a great influence on the heat treatment distortion of an automotive gear steel FAS3420H. In order to understand the distortion process of the segregation region during hot‐rolling process, a finite element (FE) analysis of the whole hot‐rolling process was carried out by software DEFORM‐3D, and a constructed constitutive model was embedded into DEFORM‐3D to describe the deformation process. The results show there is an inhomogeneous strain distribution at the cross‐section of hot‐rolled round bar, which results in uneven distortion of the segregation region in different directions. A square segregation region, which can reduce inhomogeneous distortion of gear in the subsequent heat treatment, is obtained after being rolled by simulation calculation verified through experiment.
Numerical analysis of flow behaviour, grain size prediction and experimental verification of hot rolled ultralow carbon niobium microalloyed steel
Authors: Khalifa H. , Megahed G.M. , El‐Bitar T. , Taha M.A. 
Published: July 2021

AbstractNiobium bearing ultralow carbon micro alloyed dual phase steel grade steel with chemical composition of 0.045 wt.% carbon, 0.04 wt.% niobium, 0.59 wt.% chromium, 0.9 wt.% manganese, 0.28 wt.% silicon is investigated. The design of thermomechanical treatment needs knowledge about the flow behaviour at high deformation temperatures, to be used for this steel in industrial plants. Therefore, this work aims to predict, for the investigated steel, the flow behaviour and mean flow stress. A phenomenological constitutive model is established to derive the flow stress using the hyperbolic sinusoidal Arrhenius mathematical model. The relation between stress and strain with Zener‐Hollomon parameter is studied. Mean flow stress has been figured out by measurements taken from compact slab production plant log data using a constitutive model. The constitutive model is further verified by multiple hits of flat compression setup mode at BährTTS820 physical simulator. The tests were performed under specific thermochemical schedule simulating compact slab production plant. The results show good agreement between the calculated flow stress, Non‐recrystallization temperature and experimentally measured values obtained from the physical simulation. Ferrite grain size is modelled and predicted then validated by experimental rolled specimens in a practical hot strip mill.
The important role of titanium microalloying in refining austenite grain of heavy‐duty H‐beam steel during rough rolling produced by a new technology
Authors: Wang Y. , Li J. , Li F. , Ge Z. , Xing J. , Li Na , Zhu G. , Ding H. , Chen Q. 
Published: July 2021

AbstractA new technology of austenite grain refinement, fine austenite enhanced ferrite transformation, is proposed for heavy‐duty hot‐rolled H‐beam steels in this work. Titanium microalloying is very important and necessary for the new technology. The effect of titanium on the prior austenite grain size of steels during simulated rough rolling was investigated. The results show that the prior austenite grain sizes of specimens with titanium and niobium elements are much finer than those of specimens with niobium but without titanium deformed at the same parameters. For the alloying composition of studied steels, titanium nitride particle maybe precipitated in specimens with titanium at above 1,200 °C, however, niobium carbide particles can't form in specimens without titanium at above 1,150 °C. The thermodynamically stable titanium nitride particles can impede the grain growth at high temperature for example furnace heating before rough rolling and bring the epitaxial growth of niobium carbide on pre‐existing themselves which induces a large number of titanium nitride‐niobium carbide composite precipitates. These fine precipitates can pin austenite grain boundaries effectively and ensure austenite grain refinement.
Efficient approach for dielectric permittivity measurements of liquids adopting a 3D‐printed cavity resonator
Authors: Rocco Giulia Maria , Barmuta Paweł , Bao Xiue , Schreurs Dominique , Bozzi Maurizio 
Published: July 2021

AbstractThis paper presents an operator‐friendly and cost‐efficient approach to characterize the dielectric permittivity of liquids flowing in narrow tubes, such as drainage tubes used as part of the wound healing process in hospitals. The approach is based on an oscillator such that the characterization can be achieved with minimal operator (e.g., nurse) training. The oscillator's frequency is set by a 3D‐printed cavity resonator as to offer flexibility for the tube line to pass through. The oscillator design had to be tailored to ensure the oscillation condition to be met over a wide range of varying liquid compositions passing through the 3D‐printed cavity resonator. The design and results of a proof‐of‐concept implementation are presented and discussed.
Hybrid cross entropy—cuckoo search algorithm for solving optimal power flow with renewable generators and controllable loads
Authors: Sarda Jigar , Pandya Kartik , Lee Kwang Y. 
Published: July 2021

AbstractThe demand of energy is increasing due to the growing population of the world and improvements of technology. One of the best significant solution techniques to fulfill this energy demand is utilization of renewable energy sources (RESs). Modern power systems, which integrate RESs, such as wind, small hydro or solar energy sources need to carry out the uncertainty by the accessibility of demanded or injected power. Therefore, it is necessary to consider uncertainty costs in optimal power flow (OPF) problems. This paper proposed a novel hybrid meta‐heuristic algorithm entitled cross entropy—cuckoo search algorithm (CE‐CSA). The application of levy flights in the cuckoo search algorithm (CSA) improves the local exploitation capability while the CE method is used in the initial stage for global exploration due to its fast convergence. The effectiveness of the proposed hybrid algorithm has been demonstrated in solving the OPF problem, considering RESs and controllable loads for different stochastic scenarios in a benchmark system to minimize the total operation cost. To verify its effectiveness, its performance is compared with the most advanced and recently proposed hybrid meta‐heuristic techniques. Simulation results show that the proposed algorithm can solve the OPF problems with RESs and controllable loads efficiently and can give better solutions compared to different techniques. The conventional statistical method called analysis of variance (ANOVA) test, Tukey honestly significant difference test, and Wilcoxon sign rank test are performed for comparative analysis of different techniques. The results of this test show the validation of CE‐CSA compared to different optimization techniques.