bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology and democracy: a paradox wrapped in a contradiction inside an irony
Authors: Lewandowsky Stephan , Pomerantsev Peter 
Published: December 2021

Abstract
Democracy is in retreat around the globe. Many commentators have blamed the Internet for this development, whereas others have celebrated the Internet as a tool for liberation, with each opinion being buttressed by supporting evidence. We try to resolve this paradox by reviewing some of the pressure points that arise between human cognition and the online information architecture, and their fallout for the well-being of democracy. We focus on the role of the attention economy, which has monetised dwell time on platforms, and the role of algorithms that satisfy users’ presumed preferences. We further note the inherent asymmetry in power between platforms and users that arises from these pressure points, and we conclude by sketching out the principles of a new Internet with democratic credentials.
Ingestion of an ample amount of meat substitute based on a lysine-enriched, plant-based protein blend stimulates postprandial muscle protein synthesis to a similar extent as an isonitrogenous amount of chicken in healthy, young men
Authors: Kouw Imre W.K. , Pinckaers Philippe J.M. , Le Bourgot Cindy , van Kranenburg Janneau M.X. , Zorenc Antoine H. , de Groot Lisette C.P.G.M. , Verdijk Lex , Snijders Tim , van Loon Luc J.C. 
Published: December 2021

AbstractPlant-based proteins are considered to be less effective in their capacity to stimulate muscle protein synthesis when compared with animal-based protein sources, likely due to differences in amino acid contents. We compared the postprandial muscle protein synthetic response following the ingestion of a lysine-enriched plant-based protein product with an isonitrogenous amount of chicken. Twenty-four men (age 24 ± 5 years; BMI 22·9 ± 2·6 kg·m−2) participated in this parallel, double-blind, randomised controlled trial and consumed 40 g of protein as a lysine-enriched wheat and chickpea protein product (Plant, n 12) or chicken breast fillet (Chicken, n 12). Primed, continuous intravenous l-(ring-13C6)-phenylalanine infusions were applied while repeated blood and muscle samples were collected over a 5-h postprandial period to assess plasma amino acid responses, muscle protein synthesis rates and muscle anabolic signalling responses. Postprandial plasma leucine and essential amino acid concentrations were higher following Chicken (P < 0·001), while plasma lysine concentrations were higher throughout in Plant (P < 0·001). Total plasma amino acid concentrations did not differ between interventions (P = 0·181). Ingestion of both Plant and Chicken increased muscle protein synthesis rates from post-absorptive: 0·031 ± 0·011 and 0·031 ± 0·013 to postprandial: 0·046 ± 0·010 and 0·055 ± 0·015 % h−1, respectively (P-time < 0·001), with no differences between Plant and Chicken (time x treatment P = 0·068). Ingestion of 40 g of protein in the form of a lysine-enriched plant-based protein product increases muscle protein synthesis rates to a similar extent as an isonitrogenous amount of chicken in healthy, young men. Plant-based protein products sold as meat replacers may be as effective as animal-based protein sources to stimulate postprandial muscle protein synthesis rates in healthy, young individuals.
Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway
Authors: Hao Qi , Wang Lulu , Zhang Minghui , Wang Zhe , Li Meng , Gao Xuejun 
Published: December 2021

AbstractTaurine (Tau) has many profound physiological functions, but its role and molecular mechanism in muscle cells are still not fully understood. In this study, we investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells. Cells were treated with Tau (0, 60, 120, 180 and 240 μM) for 24 h. Tau dose-dependently promoted protein synthesis, cell proliferation, mechanistic target of rapamycin protein (mTOR) phosphorylation and also AT-rich interaction domain 4B (ARID4B) expression, with the best stimulatory effects at 120 μM. LY 294002 treatment showed that Tau promoted ARID4B expression in a phosphoinositide 3-kinase (PI3K)-dependent manner. ARID4B knockdown (by small interfering RNA transfection for 24 h) prevented Tau from stimulating protein synthesis and cell proliferation, whereas ARID4B gene activation (using the CRISPR/dCas9 technology) had stimulatory effects. ARID4B knockdown abolished Tau signalling to mRNA expression and protein phosphorylation of mTOR, whereas ARID4B gene activation had stimulatory effects. Chromatin immunoprecipitation (ChIP)-PCR identified that all of ARID4B, H3K27ac and H3K27me3 bound to the −4368 to –4591 bp site in the mTOR promoter, and ChIP-quantitative PCR (qPCR) further detected that Tau stimulated ARID4B binding to this site. ARID4B knockdown or gene activation did not affect H3K27me3 binding to the mTOR promoter but decreased or increased H3K27ac binding, respectively. Furthermore, ARID4B knockdown abolished the stimulation of Tau on H3K27ac binding to the mTOR promoter. In summary, these data uncover that Tau promotes protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway, providing a deep understanding of how Tau regulates anabolism in muscle cells.
Larvae ecology and adult activity ofAedes mariae(Diptera: Culicidae) in a touristic rock-pool area of the Balearic Islands (Western Mediterranean)
Authors: Bengoa Mikel , Rotger Andreu , Luzón Raúl , Barceló Carlos 
Published: December 2021

AbstractMosquitoes are vectors of several diseases of medical concern such as malaria or dengue and can also negatively affect tourism and the life-quality of the neighbourhood. The speciesAedes mariae(Sergent and Sergent, 1903) is a poorly studied mosquito that breeds in rock-pools of the Mediterranean coast. General Linear Mixed Models (GLMM) were used to determine drivers affecting the presence and abundance of this species. Abiotic and biotic factors were recorded in rock-pools with the presence ofAe. mariaesub-adults across a supralittoral area of Majorca Island (Balearic Islands, Spain) from July 2018 to June 2019. We tested how abiotic factors affected the presence of larvae, while the biotic factors were used to check their effect on larvae abundance. human landing collection was also conducted to assess the adult activity of this species. Valuable data were recorded to improve our knowledge about the bioecology ofAe. mariaein a touristic area of the island of Majorca. Salinity and pH were the most explanatory variables for the presence ofAe. mariaelarvae. The presence ofPosidonia oceanica(L.) Delile 1813 leaves negatively affected the abundance ofAe. mariaelarvae while the presence of other fauna enhanced it. Adult females ofAe. mariaewere active for 26 min after sunset in June and its host-seeking activity decreased during autumn months. Control methods against this species should be focussed on rock-pools and planning treatments according to tides, waves and precipitation.
The Testimony for Marcion's Gospel in NA28: Revisiting the Apparatus to Luke in the Light of Recent Research
Authors: Roth Dieter T. 
Published: December 2021

AbstractScholarly work on Luke has often noted the significance of Marcion's Gospel for understanding the textual history of the third canonical Gospel. It is not surprising, therefore, that in the past new insights into Marcion's Gospel have led to revisions in the apparatus of the highly influential Nestle-Aland Novum Testamentum Graece, now in its 28th edition. In view of the precedent for continually updating the Nestle-Aland text and apparatus, this article revisits the apparatus to Luke in the light of recent research on Marcion's Gospel in order to highlight problematic references that should be changed or removed in the apparatus of future Nestle-Aland editions.
Suppressed activity of the rostral anterior cingulate cortex as a biomarker for depression remission
Authors: Davey Christopher G. , Cearns Micah , Jamieson Alec , Harrison Ben J. 
Published: December 2021

AbstractBackgroundSuppression of the rostral anterior cingulate cortex (rACC) has shown promise as a prognostic biomarker for depression. We aimed to use machine learning to characterise its ability to predict depression remission.MethodsData were obtained from 81 15- to 25-year-olds with a major depressive disorder who had participated in the YoDA-C trial, in which they had been randomised to receive cognitive behavioural therapy plus either fluoxetine or placebo. Prior to commencing treatment patients performed a functional magnetic resonance imaging (fMRI) task to assess rACC suppression. Support vector machines were trained on the fMRI data using nested cross-validation, and were similarly trained on clinical data. We further tested our fMRI model on data from the YoDA-A trial, in which participants had completed the same fMRI paradigm.ResultsThirty-six of 81 (44%) participants in the YoDA-C trial achieved remission. Our fMRI model was able to predict remission status (AUC = 0.777 [95% confidence interval (CI) 0.638–0.916], balanced accuracy = 67%, negative predictive value = 74%, p < 0.0001). Clinical models failed to predict remission status at better than chance levels. Testing the model on the alternative YoDA-A dataset confirmed its ability to predict remission (AUC = 0.776, balanced accuracy = 64%, negative predictive value = 70%, p < 0.0001).ConclusionsWe confirm that rACC activity acts as a prognostic biomarker for depression. The machine learning model can identify patients who are likely to have difficult-to-treat depression, which might direct the earlier provision of enhanced support and more intensive therapies.
The Pandemic Paranoia Scale (PPS): factor structure and measurement invariance across languages
Authors: Kingston J. L. , Schlier B. , Ellett L. , So S. H. , Gaudiano B. A. , Morris E. M. J. , Lincoln T. M. 
Published: December 2021

AbstractBackgroundGlobally, the corona virus disease 2019 (COVID-19) pandemic has created an interpersonally threatening context within which other people have become a source of possible threat. This study reports on the development and validation of a self-report measure of pandemic paranoia; that is, heightened levels of suspicion and mistrust towards others due to the COVID-19 pandemic.MethodsAn international consortium developed an initial set of 28 items for the Pandemic Paranoia Scale (PPS), which were completed by participants from the UK (n = 512), USA (n = 535), Germany (n = 516), Hong Kong (n = 454) and Australia (n = 502) using stratified quota sampling (for age, sex and educational attainment) through Qualtrics and translated for Germany and Hong Kong.ResultsExploratory factor analysis in the UK sample suggested a 25-item, three-factor solution (persecutory threat; paranoid conspiracy and interpersonal mistrust). Confirmatory factor analysis (CFA) on the remaining combined sample showed sufficient model fit in this independent set of data. Measurement invariance analyses suggested configural and metric invariance, but no scalar invariance across cultures/languages. A second-order factor CFA on the whole sample indicated that the three factors showed large loadings on a common second-order pandemic paranoia factor. Analyses also supported the test–retest reliability and internal and convergent validity.ConclusionThe PPS offers an internationally validated and reliable method for assessing paranoia in the context of a pandemic. The PPS has the potential to enhance our understanding of the impact of the pandemic, the nature of paranoia and to assist in identifying and supporting people affected by pandemic-specific paranoia.
Exploring evolving caring relationship experiences among nursing home residents and nurse aides in Shanghai: a dyadic perspective
Authors: Chen Lin , Zhu Qiang , Xu Ling , Lee Yura , Kim Bum Jung 
Published: December 2021

AbstractAlthough research has shown that older nursing home residents can benefit from caring relationships with nurse aides, few studies have explored their dyadic, evolving relationship dynamics. Using a dyadic perspective, this study simultaneously explores caring relationships among older residents and nurse aides in Shanghai. In a government-sponsored nursing home in Shanghai, 20 matched resident–nurse aide dyads participated in semi-structured, in-depth interviews (N = 40). We performed thematic analysis to interpret and conceptualise the evolving caring relationships within dyads. Four types emerged during the evolution of caring relationships across the 20 dyads: (a) sharing strong rapport, (b) respecting each other, (c) hesitant responding, and (d) keeping emotional distance. Upon placement, all the residents kept emotional distance from nurse aides, and their assigned nurse aides provided care-giving by following nursing home regulations. As time passed, nurse aides began to create a family environment and tried to interact with residents on an emotional level; however, residents’ attitudes varied. The caring relationships in some dyads evolved as rapport and respect emerged, while others remained hesitant and distant. This suggests that residents and nurse aides prioritised caring relationships differently in terms of autonomy preservation and safety protection, respectively. This study sheds light on nursing home practice to facilitate building caring relationships between residents and nurse aides.
Lineage Solidarity and Rhetorical Resonance: Village Strategies to Retain Primary Schools in Rural China
Authors: Tian Felicia F. , Song Jing , Du Shichao 
Published: December 2021

AbstractAs the state has shifted its priorities towards social harmony and poverty alleviation, this study finds rhetorical resonance, combined with strong lineage solidarity, as an emerging strategy for villages to compete for government resources and investments. By articulating grassroots needs as being in line with local cadres’ performance goals, villages have successfully converted their needs into development proposals and mobilized lineage solidarity to persuade local cadres of the feasibility of such proposals. Drawing on three villages’ school-saving efforts in Fujian province, our fieldwork illustrates how one village retained its school by mobilizing lineage solidarity and converting education into a “model” village project to boost cultural tourism. Others failed to do so and lost their schools. Under the target-based cadre management system, the bottom-up competition for government support is largely shaped by the villages’ pre-existing development and resource structures, which may maximize management efficiency but may also reinforce socioeconomic inequalities between villages.
Nutrition knowledge among university students in the UK: a cross-sectional study
Authors: Belogianni Katerina , Ooms Ann , Lykou Anastasia , Moir Hannah Jayne 
Published: December 2021

AbstractObjective:To investigate nutrition knowledge (NK) in university students, potential factors affecting knowledge and predictors of good NK.Design:A cross-sectional study was conducted in 2017–2018. The revised General Nutrition Knowledge Questionnaire was administered online to assess overall NK and subsections of knowledge (dietary recommendations, nutrient sources of foods, healthy food choices and diet–disease relationships). The Kruskal–Wallis test was used to compare overall NK scores according to sex, age, ethnicity, field of study, studying status, living arrangement, being on a special diet and perceived health. Logistic regression was performed to identify which of these factors were associated with a good level of NK (defined as having an overall NK score above the median score of the sample population).Setting:Two London-based universities.Participants:One hundred and ninety students from various academic disciplines.Results:The highest NK scores were found in the healthy food choices (10 out of 13 points) and the lowest in the nutrient sources of foods section (25 out of 36 points). Overall NK score was 64 out of 88 points, with 46·8 % students reaching a good level of knowledge. Knowledge scores significantly differed according to age, field of study, ethnicity and perceived health. Having good NK was positively associated with age (OR = 1·05, (95 % CI 1·00, 1·1), P < 0·05), White ethnicity (OR = 3·27, (95 % CI 1·68, 6·35), P < 0·001) and health rating as very good or excellent (OR = 4·71, (95 % CI 1·95, 11·4), P < 0·05).Conclusions:Future health-promoting interventions should focus on increasing knowledge of specific nutrition areas and consider the personal and academic factors affecting NK in university students.
Design of a high-gain dual-band antipodal Vivaldi antenna array for 5G communications
Authors: Kumar Sumit , Dixit Amruta S. 
Published: December 2021

AbstractThis paper presents a dual-band 1 × 4 antipodal Vivaldi antenna (AVA) array with high gain to operate over a dual-frequency band that covers the 5G frequency spectrum. The gain is enhanced by employing a dielectric lens (DL). The AVA array consists of four radiating patch elements, corrugations, DL, and array feeding network on the top side. The bottom side contains four radiating patches which are the mirror images of top radiating patches. The designed AVA contains 1 × 4 array antenna elements with a DL that is operating in the ranges of 24.59–24.98 and 27.06–29 GHz. The dimensions of the designed antenna are 97.2 mm × 71.2 mm × 0.8 mm. For the improvement in gain and impedance matching at the dual-band frequency, corrugation and feeding network techniques are used. The gain obtained is about 8–12 dBi. AVA array is tested after fabrication and the measured results are reliable with the simulation results.
Human well-being in the Anthropocene: limits to growth
Authors: Collste David , Cornell Sarah E. , Randers Jorgen , Rockström Johan , Stoknes Per Espen 
Published: December 2021

Non-technical summary
Transformation of the world towards sustainability in line with the 2030 Agenda requires progress on multiple dimensions of human well-being. We track development of relevant indicators for Sustainable Development Goals (SDGs) 1–7 against gross domestic product (GDP) per person in seven world regions and the world as a whole. Across the regions, we find uniform development patterns where SDGs 1–7 – and therefore main human needs – are achieved at around US$15,000 measured in 2011 US$ purchasing power parity (PPP).

Technical summary
How does GDP per person relate to the achievement of well-being as targeted by the 2030 Agenda? The 2030 Agenda includes global ambitions to meet human needs and aspirations. However, these need to be met within planetary boundaries. In nascent world-earth modelling, human well-being as well as global environmental impacts are linked through economic production, which is tracked by GDP. We examined historic developments on 5-year intervals, 1980–2015, between average income and the advancement on indicators of SDGs 1–7. This was done for both seven world regions and the world as a whole. We find uniform patterns of saturation for all regions above an income threshold somewhere around US$15,000 measured in 2011 US$ PPP. At this level, main human needs and capabilities are met. The level is also consistent with studies of life satisfaction and the Easterlin paradox. We observe stark differences with respect to scale: the patterns of the world as an aggregated whole develop differently from all its seven regions, with implications for world-earth model construction – and sustainability transformations.

Social media summary
Reaching human well-being #SDGs takes GDP levels of $15k. This may help shape transformation to a world that respects #PlanetaryBoundaries.
The evolution of knowledge processing and the sustainability conundrum
Authors: Grumbach Stéphane , van der Leeuw Sander 
Published: December 2021

Non-technical summaryOur time seems to be trapped in a paradox. On the one hand, the capacity to master information has tremendously increased, but on the other hand the capacity to use the knowledge humanity produces seems at stake. There is a gap between our capacity to know and our capacity to act. We attempt to better understand that situation by considering the evolution of knowledge processing along human history, in particular the relation between the development of information technologies and the complexity of societies, the balance between the known and the unknown, and the current emergence of autonomous machines allowing intelligent processes.Technical summaryInformation-processing capacities developed historically in conjunction with the complexity of human societies. Positive feedback loops contributed to the co-evolution of knowledge, social organization, environmental transformation, and information technologies. Very powerful loops now drive the rapid emergence of global digital platforms, disrupting legacy organizations and economic equilibria. The simultaneous emergence of the awareness of the sustainability conundrum and the digital revolution is striking. Both are extremely disruptive and contribute to a surge in complexity, but how do they relate to each other? Paradoxically, as the capacity to master information increases, the capacity to use the knowledge humanity produces seems to lag. The objective of this paper is to analyze the current divergence between knowledge and action, from the angle of the co-evolution of information processing and societal transformation. We show how the interplay between perception and action, between the known and the unknown, between information processing and ontological uncertainty, has evolved toward a sense of control, a hubris, which abolishes the unknown and hinders action. A possible outcome of this interplay might lead to a society controlled to stay in its safe operating space, involving a strong delegation of information processing to autonomous machines, as well as extensive forms of biopolitics.Social media summaryThe sustainability conundrum and the digital revolution are entangled phenomena leading to complexity and disruption.
Large Hemoglobin Differences at Birth in Monochorionic Twins with a Placental Chorangioma and Delayed Cord Clamping
Authors: Groene Sophie G. , Tollenaar Lisanne S.A. , van der Meeren Lotte E. , Slaghekke Femke , Verweij E. Joanne , Hooper Stuart B. , te Pas Arjan B. , Lopriore Enrico 
Published: December 2021

AbstractWe report a case of a monochorionic diamniotic twin with an uncomplicated pregnancy, but with an unexpected large intertwin hemoglobin (Hb) difference at birth. Twin 1 was delivered vaginally and had an uneventful neonatal course. The umbilical cord of Twin 1 was clamped approximately 5 min after birth. After the birth of Twin 1, Twin 2 developed severe bradycardia and showed limited cardiac output on ultrasound, for which an emergency cesarean section was performed. A full blood count revealed an Hb of 20.1 g/dL for Twin 1 and 10.2 g/dL for Twin 2 (intertwin difference 9.9 g/dL). Reticulocyte counts were similar, 40‰ and 38‰, respectively. Placental examination revealed 10 vascular anastomoses, including one arterio-arterial anastomosis with a diameter of 1.4 mm. Additionally, a large chorangioma was present on the placental surface of Twin 2. There was no color difference on the maternal side of the placenta. Based on the reticulocyte count ratio and the placental characteristics, twin anemia polycythemia sequence was ruled out as the cause of the large intertwin Hb difference. In this report, we discuss the various potential causes that could explain the large intertwin Hb difference including the role of delayed cord clamping in Twin 1, and the role of a large chorangioma, which may have attracted blood from the fetal circulation of Twin 2.