bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can ion exchange resins be used for extracorporeal circulation therapy of hyperkalemia?
Authors: Orihara Kazuhiro , Yamaka Toshihiko , Matsuda Yasuhiro 
Published: February 2025

Abstract

Background
Severe hyperkalemia leads to severe arrhythmias, and hemodialysis is necessary when renal dysfunction occurs. However, hemodialysis has equipment limitations and requires a large amount of water. The response to hyperkalemia is even more serious, especially in times of disaster, when hemodialysis cannot be performed because of damage to medical facilities and the disruption of lifelines. In this study, the extracorporeal circulation method was considered an alternative to hemodialysis for hyperkalemia.

Methods
Potassium ion removal was based on the adsorption method, and adsorption columns were prepared with cation exchange resins. The extracorporeal circulation method was determined on the basis of changes in column inlet pressure via the direct hemoperfusion method, in which whole blood was passed through the column, and the plasma perfusion method, in which plasma obtained by plasma separation was passed through the column, using blood samples from the same swine. Circulation tests were conducted via this determined extracorporeal circulation method, and changes in electrolytes were observed.

Results
Considering that the extracorporeal circulation method is based on the column inlet pressure, which increases in the direct hemoperfusion method and is stable in the plasma reflux method, the filtration method is defined as the process in which the blood cell components are removed and passed through the column. Statistical examination of the electrolyte changes in the blood via the filtration method revealed a significant decrease in sodium and potassium ions and a significant increase in calcium ions at the filter inlet; a significant increase in sodium and calcium ions and a significant decrease in potassium ions at the column inlet; and significant decreases in sodium and calcium ions and significant increases in potassium ions at the column outlet.

Conclusions
Using the filtration method, it was possible to reduce potassium ions from hyperkalemic swine blood. This method can reduce potassium ion concentrations without equipment and facilities required for hemodialysis or the use of large amounts of dialysate or water and can contribute to the treatment of hyperkalemia in medical facilities without hemodialysis facilities or in disaster situations.
Focal cortical dysplasia type II: review of neuropathological manifestations and pathogenetic mechanisms
Authors: Fang Yubao , Zhang Yaqian , Huang Tiancai , Yang Shengyu , Li Yinchao , Zhou Liemin 
Published: February 2025

Abstract
Focal cortical dysplasia (FCD) is an important cause of intractable epilepsy, with FCD type II (FCD II) being the most common subtype. FCD II is characterized by cortical dyslamination accompanied by dysmorphic neurons (DNs). Identifying the molecular alterations and targetable biomarkers is pivotal for developing therapies. Here, we provide a detailed description of the neuropathological manifestations of FCD II, including morphological alterations and immunophenotypic profiles, indicating that abnormal cells exhibit a diverse spectrum of mixed differentiation states. Furthermore, we summarize current research on the pathogenetic mechanisms, indicating that gene mutations, epigenetic alterations, cortical developmental protein disturbances, inflammatory processes, and extrinsic damages may lead to abnormal neuronal proliferation and migration, thereby contributing to the emergence and progression of FCD II. These findings not only enhance our understanding of the pathogenesis of FCD II but also offer new directions for clinical diagnosis and treatment. Future research should further explore the interactions among these factors and employ multidisciplinary approaches to advance our understanding of FCD II.
A scoping review of the literature on the application and usefulness of the Problem Management Plus (PM+) intervention around the world
Authors: Mwangala Patrick N. , Makandi Millicent , Kerubo Anita , Nyongesa Moses K. , Abubakar Amina 
Published: February 2025

BackgroundGiven the high rates of common mental disorders and limited resources, task-shifting psychosocial interventions are needed to provide adequate care. One such intervention developed by the World Health Organization is Problem Management Plus (PM+).AimsThis review maps the evidence regarding the extent of application and usefulness of the PM+ intervention, i.e. adaptability, feasibility, effectiveness and scalability, since it was introduced in 2016.MethodWe conducted a scoping review of seven literature databases and grey literature from January 2015 to February 2024, to identify peer-reviewed and grey literature on PM+ around the world.ResultsOut of 6739 potential records, 42 met the inclusion criteria. About 60% of the included studies were from low- and middle-income countries. Findings from pilot/feasibility trials demonstrated that PM+ is feasible, acceptable and safe. Results from definitive randomised controlled trials at short-term follow-up also suggested that PM+ is effective, with overall moderate-to-large effect sizes, in improving symptoms of common mental health problems. Although PM+ was more effective in reducing symptoms of common mental disorders, it was found to be costlier compared to usual care in the only study that evaluated its cost-effectiveness.ConclusionsOur findings indicate that PM+, in its individual and group formats, can be adapted and effectively delivered by trained helpers to target a wide range of common mental health concerns. More effectiveness and implementation evidence is required to understand the long-term impact of PM+, its cost-effectiveness and scalability, and moderators of treatment outcomes such as gender and delivery formats.
Arms Race Control Score Standardizes Residency Applicant Publication Assessment
Authors: Bowers Christian A. , Covell Michael M. , Levy Elad I. , Segura Aaron C. , Varela Samantha , Soliman Mohamed A. R. , Mullin Jeffrey P. , Courville Evan , Quiceno Esteban , Roy Joanna , Moisi Marc , Delashaw Johnny , Hall Daniel E. , Chambless Lola B. , Piccirillo Sara G. M. , Kogan Michael 
Published: February 2025

BACKGROUND AND OBJECTIVES:
The publication “arms race” refers to the recent, exponential increase in publications among residency “Match” applicants. Total number of residency applicant publications is the strongest predictor of “Match” success in neurosurgery beyond licensing examination scores. This study sought to introduce an objective metric by which publications may be scored to assess residency applicant authorship effort.

METHODS:
A retrospective, quantitative assessment of 537 publications by 57 interviewed applicants at a neurosurgery residency program was conducted from the 2022 to 2023 “Match” cycle. A 4-point scale was used to calculate a Publication Effort Score (PES) for each publication, ranging from a letter/editorial/historical commentary (PES = 1) to a high-effort clinical/basic science/cadaveric study (PES = 4). Each PES was subsequently divided by the applicant's authorship position to assign a corresponding publication value unit (PVU), which was calculated for each applicant publication and summated for an applicant's cumulative PVU (cPVU). An Arms Race Control Score (ARCS) was calculated by eliminating all minimal effort publications (PVU ≤ 1) from the cPVU score.

RESULTS:
Mean publication number among applicants was 9.28 (±10.7), with approximately one-third (31.8%, N = 169) of publications first-authored by an applicant. Approximately one-quarter (26.1%, N = 140) of publications were minimal effort publications. A minority of publications (41.3%, N = 222) had a PVU of greater than 2. ARCS implementation resulted in a major ranking change (±≥5 positions) for 61.4% (N = 35) of applicants, ranging from an increase in 22 positions to a decrease in 26 positions. Following ARCS, four positions changed among applicants ranked 1 to 10.

CONCLUSION:
ARCS standardizes residency applicant publication assessment by attempting to capture applicant authorship effort. ARCS implementation may drive residency applicants to focus on higher effort publications, offering a novel solution to the publication “arms race.” Automated ARCS scoring for the upcoming “Match” cycle may be calculated using an applicant's last name and publications' PubMed IDs using https://arcscalculator.com.
Double-sided gastric perforation after a motorcycle accident in Korea: A case report
Authors: Cho In Soo , Park Chan Hee , Lee Jeong Woo 
Published: February 2025

BACKGROUND
Motorcycle accidents often result in abdominal trauma in patients seeking emergency care. Injuries to the hollow viscera, including the duodenum, jejunum, urinary bladder, and colorectum, are relatively common. In contrast, owing to the protective function of the anterior rib cage, gastric rupture is exceptionally rare, with an incidence of < 1.7%. Gastric rupture typically occurs in the anterior wall and rarely presents as multiple ruptures. This report describes an unusual case of multiple gastric ruptures resulting from blunt trauma.
CASE SUMMARY
A 21-year-old man, who was involved in a motorcycle collision at 70 km/hour after consuming a large meal, presented with hypotension. Physical examination revealed abdominal tenderness. Laboratory test results indicated elevated amylase, lipase, and liver enzyme levels. Computed tomography showed pneumoperitoneum, hemoperitoneum, and gastric wall discontinuation, suggesting gastric perforation alongside pancreatic, splenic, and hepatic injuries. Angiographic embolization was performed because of active contrast leakage in the left gastric and right gastroepiploic arteries. Emergency laparotomy revealed substantial blood loss, hematoma, and gastric contents scattered throughout the abdominal cavity. Two 10 cm gastric perforations in the anterior and posterior walls were identified, as well as severe liver damage, splenic injury, and pancreatic contusion. Surgical interventions included primary closure of the gastric wall, splenectomy, and partial hepatectomy. After temporary abdominal closure, the patient underwent a second surgery without further bleeding. The gastric repair site was resected and reinforced for optimal tissue healing.
CONCLUSION
Gastric rupture following blunt trauma is fatal. However, patients without severe complications can recover through surgical interventions and postoperative care.
Exploring technical implications and design opportunities for interactive and engaging telepresence robots in rehabilitation – results from an ethnographic requirement analysis with patients and health-care professionals
Authors: Unbehaun David , Kirsch Marcel , Schulte-Huermann Johannes , Beckmann Julia , Schulz Dominik , Thiel Katharina , Fritz Thomas , Wulf Volker 
Published: February 2025

Abstract
This paper explores technical implications and design opportunities that are conceptualized to inform a socio-robotic system with digital applications to support the recovery process of patients within a rehabilitation facility. By conducting observations and interviews with patients and therapists, we identified key challenges and design opportunities in a specific orthopaedic rehabilitation context and process. The findings indicate the design potentials of a socio-robotic system to enhance patient engagement and recovery by providing personalized activities, a meaningful interaction and a motivating surrounding by using music-based exercises. Our research suggests that integrating digital applications with robotic systems may be used in the long-run to offer tailored exercises, stimulating concepts to motivate and maintain patients in therapy process, real-time feedback, and data-driven progress tracking, thereby improving the overall therapeutic outcomes. By addressing these factors, our proposed socio-robotic system aims to create a more interactive and engaging orthopaedic rehabilitation experience and environment, ultimately supporting patient recovery and improving overall treatment.
Luck Egalitarianism, Exploitation, and the Normative Foundations of Socialism
Authors: MacRae Callum Zavos 
Published: February 2025

Abstract
According to a prominent account, the central normative commitments of socialism are a luck egalitarian principle of equality and a principle of community or solidarity. The model has a number of attractions. However, it appears to be vulnerable to a series of objections that have been pressed against luck egalitarian accounts of the concept of exploitation. In this paper I argue that, despite some overlooked flexibility, the exploitation objection represents a serious challenge to this model and provides a good reason to explore alternative accounts of socialism’s normative grounds.
Bending of wavy spider web honeycomb sandwich structures using PLA
Authors: Solak Alparslan , Aşçıoğlu Temiztaş Birgül , Bolat Berna 
Published: February 2025

Abstract
This study investigates the bending performance of wavy spider web honeycomb sandwich structures produced using polylactic acid (PLA) through 3D printing technology. The primary objective is to enhance mechanical efficiency per unit mass by integrating wave and spider web profiles, a novel approach in the literature. Tensile specimens and sandwich structures were manufactured according to ASTM standards, and their mechanical properties, including stress-strain curves, modulus of elasticity, and Poisson’s ratio, were determined through tensile tests. Bending tests on straight, wavy, and spider web designs were conducted to obtain force-deformation curves and post-testing damage images. Finite element models in Ls-Dyna, validated by experimental data, showed that the wavy model achieved the highest specific energy absorption (sEA) while the spider web model exhibited the highest specific peak crushing force (sPCF). The wavy spider web model demonstrated the second-highest values for both metrics, supporting the development of next-generation sandwich structures where specific strength and energy absorption are critical.
Etched in Stone: The Kevermes Stone Stela From the Great Hungarian Plain
Authors: Gyucha Attila , Bóka Gergely , Kasztovszky Zsolt , Miklós Dóra Georgina , Galaty Michael L. , Ward Timothy J. , Szemerey-Kiss Balázs , Riebe Danielle J. , Stibrányi Máté , Pethe Mihály , Kreiter Attila 
Published: February 2025

Abstract
The origin and authenticity of artifacts unearthed outside controlled archaeological excavations pose challenges for archaeologists, especially when they do not fit established patterns in the archaeological record. This article presents a detailed analysis of a stone stela discovered in non-professional circumstances on the Great Hungarian Plain. The stela’s engraved design, previously unknown in the regional archaeological record, closely resembles that of a slab in the Gavrinis passage grave in Bretagne, France. In addition to the provenance of the rock, our investigations specifically focused on the identification of the find context and the authenticity of the engravings. The results thus far support the engravings’ authenticity and suggest that the stela was removed from a Yamnaya kurgan and repurposed several millennia later. We argue that the Kevermes stela testifies to complex dynamics of long-distance mobility and cultural exchange in Europe during the late fourth and the first half of the third millennium BC.
The Boundaries of the Jobseeker Category in Europe
Authors: Clegg Daniel 
Published: February 2025

Abstract
Support for the unemployed, through income transfers and public employment programmes and services, is a core area of welfare state activity. While comparative welfare state research focuses mainly on cross-national differences in the level of this support, the development of a harmonized statistical definition of unemployment has tended to obscure continuing variations among welfare states in the extent to which situations of need are administratively recognized as unemployment in the first place. This paper illustrates this by focusing on the related but distinct category of jobseekers. Using aggregate data, it shows that the boundaries of the jobseeker category are drawn highly variably across European welfare states. Deeper comparison of two country cases then illustrates how this variation is partly shaped by the differential classification of similar needs – specifically, in these cases, of people in marginal employment – as a result of the operation of the welfare state itself.
Characteristics of behavioral and socioeconomic risk factors for noncommunicable diseases in young people with comorbidities
Authors: Afanaseva A. D. , Shcherbakova L. V. , Gafarov V. V. , Shramko V. S. , Denisova D. V. , Ragino Yu. I. 
Published: February 2025

Aim. To analyze behavioral and socioeconomic risk factors for noncommunicable diseases in young people with comorbidities.Material and methods. The population sample included 1415 people. Comorbid pathology was considered a combination of ≥3 diseases. Comorbid pathology was detected in 105 examined people.For comparison with comorbid patients, a group of healthy individuals without any of the studied diseases was formed (n=162).Results. When assessing the main socioeconomic and behavioral characteristics, healthy individuals more often report a good self-perceived health compared to individuals with comorbid pathology, while no differences were found for poor self-perceived health between the groups. Individuals with a combination of ≥3 pathological conditions were more likely to smoke, and also more often had manifestations characteristic of eating disorders, namely abdominal obesity (AO), overweight, class I and II obesity. Morbid obesity was recorded only in individuals with comorbid pathology. According to univariate regression analysis with standardization by sex and age, comorbid pathology was associated with smoking, AO and a good self-perceived health. When including socioeconomic and behavioral characteristics in the regression model, the probability of comorbid pathology increased by >3 times in smokers, slightly <3 times in men, 2,5 times in AO and with a worse self-perceived health, and was also associated with an increase in age by 1 year.Conclusion. Among young people, comorbid pathology is associated with male sex, smoking, AO and a worse health self-perception compared to healthy individuals.
Barriers to effective communication on adult vaccination: results of in-depth interviews with the population and healthcare professionals of the Arkhangelsk Oblast
Authors: Lopatina M. V. , Kriger E. A. , Nizovtseva N. R. , Kudryavtsev A. V. , Yakovleva V. A. , Zinovieva V. А. , Usova E. V. , Kontsevaya A. V. , Drapkina O. M. 
Published: February 2025

The effectiveness of communication with a doctor on vaccination often determines a patient's decision to vaccinate. However, the related difficulties and barriers remain insufficiently studied.Aim. To study the factors influencing communication between doctors and adult patients on vaccination issues.Material and methods. Based on the World Health Organization approach to adapting immunization programs, a qualitative study was conducted in May-June 2024 in the Arkhangelsk region, including 18 semi-structured personal in-depth interviews on adult vaccination with two following target groups: adult population (n=12) and health workers (n=6). The interviews were transcribed and analyzed by two independent experts using narrative content analysis.Results. According to population representatives, there were following factors hindering communication and consent to vaccination: lack of information about vaccines and possible reactions; no discussion of vaccination with a healthcare professional or a formal approach to it. According to health workers, the barriers were prejudices and myths about vaccines among the population. Among the management problems, the population noted the lack of time for doctors to discuss vaccination at the appointment; healthcare workers noted the lack of a unified information on vaccination issues, lack of visual information for patients, and logistical problems (impaired continuity in transferring information on vaccination of the population between health institutions and healthcare workers).Conclusion. The identified barriers to effective communication on vaccination can form the basis for developing measures to eliminate them and increase adult vaccination coverage. The developed and presented tool for conducting personal in-depth interviews can be used by researchers and specialists in the field of public health promotion to study the problems of communication on adult vaccination.
Reseña de: Anacreón castellano, de Francisco de Quevedo, edición crítica y anotada de Elena Gallego Moya y J. David Castro de Castro, A Coruña, SIELAE, 2018. ISBN 978-84-09-07700-7, 561 páginas
Authors: Izquierdo Adrián 
Published: February 2025

Se realiza una reseña de la edición crítica y anotada del Anacreón castellano, de Francisco de Quevedo, publicada por el SIELAE (2018).
Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model
Authors: Wasita Brian , Yudhani Ratih Dewi , Pakha Dyonisa Nasirochmi , Nurrohima Diana , Muthmainah Muthmainah , Wiyono Nanang , Fakurazi Shariza 
Published: February 2025

BACKGROUND: Oxidative stress and inflammation contribute to pancreatic cell dysfunction that promote insulin resistance in type 2 diabetes (T2D). Red rice bran contains bioactive substances with anti-inflammatory and antioxidant properties which improved insulin resistance in obese mice. However, no studies have explored the potential of ethanol extract of red rice bran (EERRB) to prevent T2D progression, particularly pancreatic fibrosis complications. This study was conducted to investigate the effect of EERRB on inflammation measured with interleukin (IL)-1β and fibrosis of pancreatic tissue in a rat model of T2D. METHODS: Rats were induced with streptozotocin and nicotinamide to induce diabetes, and then separated into five groups. One group received no treatment, while the other four received 9 mg/kg/day acarbose, 165, 330, or 660 mg/kg/day EERRB orally for 21 days. Immunohistochemistry was conducted on pancreas tissues to measure the expression of IL-1β, while pancreatic fibrosis was assessed with Masson’s Trichrome staining.RESULTS: EERRB reduced the expression of pro-inflammatory cytokine, IL-1β, in pancreas tissue in a dose dependent manner. Significantly lower IL-1β expression were found in group receiving 660 mg/kg/day EERRB (10%) compared to diabetic with no treatment group (50%) (p<0.0001). Additionally, the IL-1β expression in the highest dose of EERRB group was comparable to the group receiving acarbose (10%). CONCLUSION: This finding suggests the beneficial effect of EERRB in the hyperglycemic condition that causes oxidative stress through blocking the IL-1β expression, hence alleviating the inflammation in pancreas tissue, and have a tendency in preventing pancreatic fibrosis progression, a process implicated in T2D pathogenesis. KEYWORDS: diabetes, inflammation, pancreatic fibrosis, red rice bran