bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Social Value of Research and Health Research Priority-Setting
Authors: Wenner Danielle M. 
Published: February 2021

Abstract
This chapter discusses the social value requirement in clinical research and its intersection with health research priority-setting. The social value requirement states that clinical research involving human subjects is only ethical if it has the potential to produce socially valuable knowledge. The chapter discusses various ways to specify both the justification for and the content of the social value requirement. It goes on to consider the implications of various accounts of the content and justification for the requirement for the ethics of health research priority-setting, showing that while some accounts of the requirement are largely silent with respect to how research questions should be prioritized, others entail robust obligations to prioritize research that might benefit particular groups. The chapter also briefly examines potential arguments for something like a social value requirement in other kinds of research, specifically social scientific research.
The Phenomenology of Meditation
Authors: Silva Carlos Henrique do Carmo 
Published: February 2021

Abstract
The aim of the chapter is to compare meditation in the Western Christian tradition with the Hindu tradition, particularly from the Yoga Sūtras. Its main focus is to highlight the essential differences between meditation in these two traditions. One can find various contrasts as well as unexpected convergences, such as the description of exercises involving focused concentration and the development of a hierarchy of states of consciousness where the sense of self is progressively transformed. The chapter ends with a critical appraisal of how meditation is popularly understood today, with its healing and psychobiological emphasis. Although meditation is not a science, it can be considered an art of mind transformation: ultimately desiring and thinking minds are no longer in control but become the ferment that meditation operates on. To use St. Teresa of Ávila’s metaphor, this meditative process is like watching “a windmill that grinds without stopping” independently of the will. It is in this sense of mind transformation that meditatio and dhyāna can be conceived as rich traditions of creative human spirituality, which are radically different from the domesticated versions used today for well-being purposes.
The Evolution of Jewish Terrorism
Authors: Pedahzur Ami , Perliger Arie 
Published: February 2021

Abstract
While Jewish violence and terrorism, both early and contemporary, is closely correlated with one particular territory—Palestine or Eretz Yisrael (Land of Israel)—the chapter utilizes Rapoport’s four-waves framework in order to show that the evolution of Jewish terrorism was shaped by global dynamics and developments. More specifically, we will argue that whereas Jewish terrorism in Palestine and later in Israel consists of only two periods—the nationalist (1930s–1950s), which corresponds with the anticolonial wave, and its derivative, the nationalist-religious (1970s–present), which overlaps with the religious wave—the two missing waves, both of which were left-wing revolutionary, had a tremendous impact on political and social processes in Israel in general, and on the evolution of Jewish terrorism in particular. We conclude by discussing the implications of the similarities and differences between Jewish religious violence and other types of religious political violence.
How Are Bankers Paid?
Authors: Bennett Benjamin , Gopalan Radhakrishnan , Thakor Anjan 
Published: February 2021

Abstract
We empirically examine bank CEOs’ compensation. We find that bank CEOs (a) are paid less than their nonfinancial counterparts, an effect driven by the CEOs of small bank; (b) experienced declining compensation during 2007–2009 (the hardest-hit banks cut compensation more) but pay is now 24% higher than precrisis levels; (c) are paid more at larger banks, those with less nonperforming loans, those with a higher proportion of noninterest income, and those with less demand-deposit dependence; and (d) have pay highly sensitive to ROA and ROE, but not stock returns. Tail risk is higher when compensation depends more on short-term measures of performance. (JEL, F34, G32, G33, G38, K42)
A Meta-analysis of Cognitive Remediation for Schizophrenia: Efficacy and the Role of Participant and Treatment Factors
Authors: Lejeune Julia A , Northrop Andrew , Kurtz Matthew M 
Published: February 2021

Abstract
The number of randomized, controlled studies of cognitive remediation (CR) for schizophrenia, a therapeutic approach designed to improve cognitive skills and function, has grown substantially over the past 20 years. Active elements of CR treatment, however, remain unknown. The current meta-analysis investigated treatment, study, and participant factors in the size of observed treatment effects. Electronic databases were searched up to May 2020 using variants of the key words “cognitive remediation,” “clinical trials,” and “schizophrenia.” This search produced 73 unique, randomized, controlled trials. Data were independently extracted by 3 reviewers with excellent reliability. Random-effects models were used to assess primary cognitive and secondary symptom and functional outcomes. Moderator analyses investigated the role of a variety of treatment, study, and participant factors. The meta-analysis (4594 participants) revealed that CR produced significant small-to-moderate size improvements in all domains of cognition studied (Hedge’s gs = .19–.33). and a significant small improvement in function (Hedge’s g = .21). CR programs that included a discussion (“bridging”) group to help apply acquired cognitive skills to everyday life produced larger effects on global cognition and verbal memory. CR programs with strategy-coaching produced larger effects on episodic memory. Sample age, gender, positive, negative, and overall symptoms, and medication dose did not serve as barriers to treatment gains. CR produces small-to-moderate improvements in cognition and function in schizophrenia. Programs of CR that utilize bridging groups and strategy-coaching are more cognitively potent. Future research should focus on ways to modify CR to bolster generalization of cognitive improvements to function.
Intranasal Ketamine for Acute Pain
Authors: Rocchio Robert J. , Ward Kristina E. 
Published: February 2021

Objectives:
The aim was to review current evidence regarding the off-label use of intranasal ketamine for acute pain presenting in the setting of the emergency department, and secondary to pediatric limb injuries, renal colic, digital nerve block, and migraines.

Results:
In all 5 indications reviewed, ketamine demonstrated efficacy in reducing pain. However, when compared with other agents, ketamine did not demonstrate superiority over opioids in pediatric limb injuries or renal colic and was not as efficacious as standard therapy for migraine relief. Ketamine was also associated with a greater incidence of transient adverse reactions, such as dizziness, bitter aftertaste, fatigue, and vomiting than opioid therapies.

Discussion:
The current body of evidence is insufficient to support the use of intranasal ketamine over other standard therapies for acute pain. However, current evidence can be used when developing dosing strategies, preparing for adverse reactions, and generating hypotheses for future, more robust research.
A Meta-analysis of Dynamic Prevalence of Cognitive Deficits in the Acute, Subacute, and Chronic Phases After Traumatic Brain Injury
Authors: Tsai Ying-Chieh , Liu Chin-Jung , Huang Hui-Chuan , Lin Jiann-Her , Chen Pin-Yuan , Su Yu-Kai , Chen Chun-Ting , Chiu Hsiao-Yean 
Published: February 2021

ABSTRACT

BACKGROUND: Reports regarding prevalence of post–traumatic brain injury (TBI) cognitive deficits were inconsistent. We aimed to synthesize the prevalence of cognitive deficits after TBI in the acute, subacute, and chronic phases. METHODS: PubMed, EMBASE, and ProQuest Dissertations and Theses A&I databases were searched from the inception to April 27, 2020. Studies with prospective, retrospective, and cross-sectional designs reporting the prevalence of cognitive deficits after TBI in adults were included. RESULTS: A total of 15 articles were included for prevalence estimation. The pooled prevalence of memory and attention deficits after mild TBI was 31% and 20% in the acute phase and 26% and 18% in the subacute phase, respectively, and 49% and 54% in the subacute phase and 21% and 50% in the chronic phase after moderate-to-severe TBI. The overall prevalence of information processing speed deficits after mild TBI in the acute and subacute phases was 21% and 17%, respectively, and 57% in the chronic phase after moderate-to-severe TBI. The overall prevalence of executive dysfunction in the subacute and chronic phases was 48% and 38%, respectively, after moderate-to-severe TBI. CONCLUSION: Cognitive deficits are prevalent in the acute to chronic phases after TBI. Healthcare providers should design effective intervention targeting cognitive impairment after TBI as early as possible.
High-Dose Prednisolone for Treatment of Infantile Spasms After Presumed Perinatal Stroke
Authors: Hall Kristin R. , Golomb Meredith R. 
Published: February 2021

ABSTRACT

BACKGROUND: High-dose prednisone and prednisolone have been increasingly studied as a lower-cost alternative to adrenocorticotropic hormone for the treatment of infantile spasms, but this treatment has not been well studied in children with infantile spasms due to perinatal stroke. METHODS: We identified a girl with new-onset infantile spasms due to presumed perinatal left middle cerebral artery stroke seen in our hospital's pediatric stroke clinic in 2019. RESULTS: This girl developed infantile spasms at 9 months old. She had right hemiplegic cerebral palsy due to her perinatal stroke but had been otherwise previously healthy. Modified hypsarrhythmia was confirmed on prolonged video-electroencephalography. High-dose prednisolone at 8 mg/kg per day was initiated on the sixth day of spasms. She was treated with this dose for 2 weeks and then tapered over 5 weeks. The girl became seizure-free after receiving her first dose of prednisolone and experienced no significant adverse effects during therapy. Routine electroencephalography after completion of prednisolone taper confirmed resolution of modified hypsarrhythmia and no epileptiform discharges. She continued to make excellent development progress during and after treatment. CONCLUSION: This case suggests high-dose prednisolone could be considered for first-line therapy for children with infantile spasms due to perinatal stroke; further study is needed.
Simulation as a Dynamic Tool to Reorganize Pediatric Emergency Department Resuscitation During the Coronavirus Disease 2019 Pandemic and Beyond
Authors: Lavoie Megan E. , Tay Khoon-Yen , Good Grace , Buchhalter Lillian , Abbadessa Mary Kate , Gaines Shannon , Myers Sage 
Published: February 2021

BackgroundThe coronavirus disease 2019 pandemic has challenged hospitals and pediatric emergency department (PED) providers to rapidly adjust numerous facets of the care of critically ill or injured children to minimize health care worker (HCW) exposure to severe acute respiratory syndrome coronavirus 2.ObjectiveWe aimed to iteratively devise protocols and processes that minimized HCW exposure while safely and effectively caring for children who may require unanticipated aerosol-generating procedures.MethodsAs part of our PED's initiative to optimize clinical care and HCW safety during the coronavirus disease 2019 pandemic, regular multidisciplinary systems and process simulation sessions were conducted. These sessions allowed us to evaluate and reorganize patient flow, test and improve communication modalities, alter the process for consultation in resuscitations, and teach and reinforce the appropriate donning and use of personal protective equipment.ResultsSimulation was a highly effective method to disseminate new practices to PED staff. Numerous workflow modifications were implemented as a result of our in situ systems and process simulations. Total number of persons in the resuscitation room was minimized, use of a “command post” with remote providers was initiated, communication devices and strategies were trialed and adopted, and personal protective equipment standards that optimized HCW safety and communication were enacted.ConclusionsSimulation can be an effective and agile tool in restructuring patient workflow and care of the most critically ill or injured patients in a PED during a novel pandemic.
Simultaneous Small/Medium Umbilical Hernia Repair With Laparoscopic Sleeve Gastrectomy (LSG): Results of a Retrospective Case-matched Study
Authors: Vitiello Antonio , Berardi Giovanna , Velotti Nunzio , Schiavone Vincenzo , Musella Mario 
Published: February 2021

Purpose:
Periumbilical hernias are a common finding in morbidly obese patients undergoing bariatric surgery; however, the timing of repair is still debated. The aim of this paper is to compare the outcomes of simultaneous versus delayed mesh repair of umbilical hernia in patients undergoing laparoscopic sleeve gastrectomy (LSG).

Methods:
We retrospectively compared 2 groups of morbidly obese patients with small/medium periumbilical hernia (up to 4 cm) in a case-matched study: the first group underwent LSG with simultaneous periumbilical hernia repair; in the second, hernioplasty was performed after weight loss induced by LSG. Patients were matched at a 1:1 ratio according to age, comorbidities, defect size (<2 or ≥2 cm), and obesity grade (<40 or ≥40 kg/m2). Demographic, clinical information, hernia size, data from the surgery, and its complications were retrieved and analyzed.

Results:
In total, 40 patients were retrieved from our prospectively maintained database and divided into 2 matched groups of 20 subjects each. Baseline characteristics were comparable. After a median time of 19.8±5.6 months, the recurrence rate was not significantly different in the 2 groups. There was no difference in the rate of single complications, but overall morbidity was significantly higher in patients undergoing a 2-step approach. LSG operation time and hospital stay resulted in comparable, but total hospital stay was longer for those readmitted for delayed hernioplasty.

Conclusions:
In the case of morbidly obese patients with small/medium periumbilical hernia undergoing LSG, a simultaneous approach should be offered. Our proposed technique did not prolong operative time and showed a lower rate of overall morbidity.
Methylomic alteration in peripheral blood lymphocytes of prodromal stage and first-episode Chinese Han schizophrenia patients
Authors: Liu Yi , Lang Bing , Smith Robert C. , Wang Guodong , Wang Jijun , Liu Yong , Jin Hua , Lyu Hailong , Davis John M. , Guidotti Alessandro R. , Zhao Jingping , Wu Renrong 
Published: February 2021

AbstractBackgroundAlthough epigenetic dysregulation has long been proposed to promote the onset of schizophrenia, the landscape of the methylomic changes across the whole genome is yet established.MethodsUsing Infinium Human Methylation 850 BeadChip Array and MethylTarget sequencing method, we investigated the genome-wide methylation profiles and further validated methylation profiles of target genes in peripheral blood lymphocytes between individuals with psychosis risk syndrome (PRS), patients with first-episode schizophrenia (FES) and healthy controls (HC) in Chinese Han population.ResultsWe detected 372 sites between psychosis risk syndrome (PRS) and healthy controls (HC), which increased to 460 sites in first-episode schizophrenia (FES) with 207 sites shared. Both PRS and FES featured profound hypomethylation within gene body. Gene ontology and network annotation merged on loci enriched in disease associated signaling pathways (MAPK(Mitogen Activated Protein Kinases), Glutamatergic, GABAergic etc.).ConclusionsOur study implicated characteristic hypomethylation in both the discovery and validation cohorts inSYNGAP1, one of the frequently studied genes in neurodevelopmental disorders. This is the first methylome-wide association study between PRS and FES in Chinese Han population. Our findings provide potential biomarkers that can be used for future development of disease therapy and management.
Copy number variation profile-based genomic subtyping of premenstrual dysphoric disorder in Chinese
Authors: Xue Hong , Wu Zhenggang , Long Xi , Ullah Ata , Chen Si , Mat Wai-Kin , Sun Peng , Gao Ming-Zhou , Wang Jie-Qiong , Wang Hai-Jun , Li Xia , Sun Wen-Jun , Qiao Ming-Qi 
Published: February 2021

AbstractPremenstrual dysphoric disorder (PMDD) affects nearly 5% women of reproductive age. The symptomatic heterogeneity, along with largely unknown genetics, of PMDD have greatly hindered its effective treatment. In the present study, 127 Chinese PMDD patients of the ‘invasion’ and ‘depression’ subtypes clinically differentiated by us earlier were analyzed together with 108 non-PMDD controls for genome-wide copy number variations (CNVs). Germline genomic DNA samples from white blood cells were subjected to AluScan sequencing-based CNV profiling, which enabled clustering of patient samples readily into the V and D groups, dominated by the “invasion” and “depression” clinical subtypes, respectively; the CNVs obtained with 100-kb windows yielded two clusters that were correlated with these subtypes with a consistency of up to 89.8%. Diagnostic correlation- and frequency-based CNV features of either CNV-gain (CNVG) or CNV-loss (CNVL) that could differentiate between V and D subtypes were selected and analyzed. CNVG features located preferentially in S2-phase replicating regions and enriched with steroid hormone biosynthesis pathway of genes were found protective against PMDD. Moreover, machine learning employing the correlation-based CNV features could predict with >80% accuracy whether a genomic sample was D-type, V-type or control. In terms of their CNV profiles, the D- and V-types differed more from one another than from the controls, thereby providing a genomic basis for the clinical D-V subtyping of PMDD. Genome-wide profiling of CNVs, as a new approach to complex disease genetics, has revealed recurrent CNVs and genomic features beyond individual genes and mutations underlying PMDD clinical diversity.
Aerosphere occupancy (ψ) model of lesser short nosed fruit bat (Cynopterus brachyotisMuller, 1838) related to tree species in Asia mountainous paddy fields
Authors: Basukriadi Adi , Nurdin Erwin , Wibowo Andri , Gunawan Jimi 
Published: February 2021

AbstractBat is animal that occupies aerosphere, especially fruit bats that forage on the space around the trees. The fruit bats use whether narrow space below tree canopy or in edge space on the edge of canopy. Whereas the aerosphere occupancy of fruits bats related to the specific tree species is poorly understood. Here, this paper aims to assess and model the association of fruit batCynopterus brachyotisaerosphere occupancy (Ψ) with tree species planted in mountainous paddy fields in West Java. The studied tree species includingAlianthus altissima, Acaciasp.,Cocos nucifera, Mangifera indica, Pinussp., andSwietenia macrophylla. The result shows that the tree species diversity has significantly (x2= 27.67, P < 0.05) affected theC. brachyotisaerosphere occupancy. According to values of Ψ and occupancy percentage, high occupancy of narrow space byC. brachyotiswas observed inSwietenia macrophylla(Ψ = 0.934, 78%), followed byAlianthus altissima(Ψ = 0.803, 57%), andMangifera indica(Ψ = 913, 55%). While high occupancy of edge space was observed inMangifera indica(Ψ = 0.685, 41%), followed byPinussp. (Ψ = 0.674, 38%), andAlianthus altissimasp. (Ψ = 0.627, 36%). The best model for explainingC. brachyotisoccupation in narrow space is the tree height with preferences on high tree (Ψ~tree height, AIC = 1.574, R2= 0.5535, Adj. R = 0.4047). While for edge space occupant, the best model is also the tree height (Ψ~tree height, AIC = −26.1510, R2= 0.7944, Adj. R = 0.7258).
How to count your bugs?
Authors: Onufrieva Ksenia S. , Onufriev Alexey V. 
Published: February 2021

AbstractAbility to estimate local population density of an insect is critical in many fields, from pest management to conservation. No method currently exists that reliably connects trap catch with the insect population density, including the corresponding uncertainty. Here we report a simple and universal predictive relationship for a probability of catching an insect located a given distance away from the trap. This relationship allows to estimate, from a single catch, the most likely population density along with its statistical upper and lower bounds. To test the generality of this equation we used 10 distinct trapping data sets collected on insects from 5 different orders and major trapping methods: chemical-baited and light. For all of the datasets the equation faithfullydescribes the relationship between location of an insect and probability to catch it. The ability to estimate absolute population density from a single trap catch will significantly improve our understanding of insect population dynamics and allow for more effective research, management, and conservation programs.
Does the ratio of β-1,4-glucosidase (BG) to β-1,4-N-acetylglucosaminidase (NAG) indicate the relative resource allocation of soil microbes to C and N acquisition?
Authors: Mori Taiki , Aoyagi Ryota , Kitayama Kanehiro , Mo Jiangming 
Published: February 2021

AbstractThe ratio of β-1,4-glucosidase (BG) to β-1,4-N-acetylglucosaminidase (NAG) activity (BG:NAG ratio) is often used as an indicator of the relative resource allocation of soil microbes to C acquisition compared with N. An increasing number of recent studies have used this index to assess the nutrient status of microbes. However, the validity of this index for assessing the nutrient status of microbes is not well tested. In this study, we collected published data and tested that validity by investigating whether N fertilization elevated the BG:NAG ratio, assuming that microbes reduce their allocation to the N-acquiring enzyme (NAG) under N-enriched conditions. Of the data points, 54% (82/151) did not support the hypothesis because those studies showed lower BG:NAG ratios in N-enriched soils than under ambient conditions, especially when the ambient BG:NAG ratio was higher than 2.0 (77%, 59/77). This suggests that the BG:NAG ratio does not always indicate the microbial status for C or N limitation. Rather, we hypothesized that the decomposition stage explained the variation in BG:NAG because N addition accelerates decomposition, and the BG:NAG ratio is lower at later stages of decomposition due to the dominance of NAG-targeting C (chitin or peptidoglycan). A negative correlation of BG:NAG ratio with polyphenol oxidase activity, which increases with decomposition, supported our hypothesis.