bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of nursing case management to improve community access to care: A scoping review
Authors: Putra Alenda Dwiadila Matra , Sandhi Ayyu 
Published: June 2021

Background: Case management is an approach used to help patients locate and manage health resources as well as to enhance effective communication among patients, families, and health systems. Nurses’ role as case managers has been proven effective in reducing healthcare costs among patients with chronic diseases. However, little is known about its implementation in improving access to care in community-based settings. Objectives: This scoping review aimed to examine the components of nursing case management in improving access to care within community settings and to identify the issues of community-based nursing case management for future implications. Design: This study was conducted following the framework of scoping review.Data Sources: The authors systematically searched five electronic databases (CINAHL, PubMed, Science Direct, Scopus, and Google Scholar) for relevant studies published from January 2010 to February 2021. Only original studies involving nurses as one of the professions performing case management roles in the community-based settings, providing 'access to care' as the findings, were included. Review Methods: The article screening was guided by a PRISMA flowchart. Extraction was performed on Google Sheet, and synthesis was conducted from the extraction result.Results: A total of 19 studies were included. Five components of nursing case management to improve access to care were identified: 1) Bridging health systems into the community, 2) Providing the process of care, 3) Delivering individually-tailored health promotion and prevention, 4) Providing assistance in decision making, and 5) Providing holistic support. In addition, three issues of nursing case management were also identified: 1) Regulation ambiguity, 2) High caseloads, and 3) Lack of continuing case management training.Conclusion: Care coordination and care planning were the most frequent components of nursing case management associated with access to care. These findings are substantial to improve nurses' ability in performing the nursing process as well as to intensify nurses’ advocacy competence for future implications.
PEMANFAATAN GOOGLE CLASSROOM SEBAGAI MEDIA PEMBELAJARAN DARING DIMASA PANDEMI COVID 19 DI PRODI INFORMATIKA UNIVERSITAS BATURAJA
Authors: Muris Anggraeni Agustin 
Published: June 2021

Abstrak : Saat ini, media internet menjadi peran yang sangat penting untuk dikembangkan dalam kehidupan kita sehari-hari terutama dibidang pendidikan. Oleh karena itu, bidang pendidikan perlu menggunakan teknologi informasi dalam proses pembelajaran di kampus. Google Classroom, adalah salah satu akses gratis yang memudahkan dosen dalam proses pembelajaran jarak jauh atau e-learning. Lebih jauh, platform ini menawarkan banyak sekali keuntungan bagi penggunanya. Selain itu, platform ini dikenal sebagai alat yang mudah digunakan oleh pengguna smartphone atau laptop, serta mampu menciptakan peluang yang sama bagi semua mahasiswa dan mendorong mahasiswa untuk belajar lebih banyak tentang media internet. Penelitian ini menggunakan paradigma interpretif, dengan pendekatan kualitatif dan metode studi kasus untuk menemukan pemanfaatan Google Classroom oleh dosen Universitas Baturaja khususnya di Program Studi Informatika Fakultas Teknik dan Komputer, Peran media baru di bidang pendidikan ini menghasilkan proses yang begitu mudah untuk dilakukan dan membuat dosen dapat lebih mudah untuk mengelola tugas kelas dengan cepat dan memberikan umpan balik kepada mahasiswa secara efektif.

Kata Kunci: Google Classroom, Media Pembelajaran, Media Internet
Incremental Values of T1 Mapping in the Prediction of Sudden Cardiac Death Risk in Hypertrophic Cardiomyopathy: A Comparison With Two Guidelines
Authors: Qin Le , Min Jiehua , Chen Chihua , Zhu Lan , Gu Shengjia , Zhou Mi , Yang Wenjie , Yan Fuhua 
Published: June 2021

Background: MRI native T1 mapping and extracellular volume fraction (ECV) are quantitative values that could reflect various myocardial tissue characterization. The role of these parameters in predicting the risk of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) is still poorly understood.Aim: This study aims to investigate the ability of native T1 mapping and ECV values to predict major adverse cardiovascular events (MACE) in HCM, and its incremental values over the 2014 European Society of Cardiology (ESC) and enhanced American College of Cardiology/American Heart Association (ACC/AHA) guidelines.Methods: Between July 2016 and October 2020, HCM patients and healthy individuals with sex and age matched who underwent cardiac MRI were prospectively enrolled. The native T1 and ECV parameters were measured. The SCD risk was evaluated by the 2014 ESC guidelines and enhanced ACC/AHA guidelines. MACE included cardiac death, transplantation, heart failure admission, and implantable cardioverter-defibrillator implantation.Results: A total of 203 HCM patients (54.2 ± 14.9 years) and 101 healthy individuals (53.2 ± 14.7 years) were evaluated. During a median follow-up of 15 months, 25 patients (12.3%) had MACE. In multivariate Cox regression analysis, global native T1 mapping (hazard ratio (HR): 1.446; 95% confidence interval (CI): 1.195–1.749; P &lt; 0.001) and non-sustained ventricular tachycardia (NSVT) (HR: 4.949; 95% CI, 2.033–12.047; P &lt; 0.001) were independently associated with MACE. Ten of 86 patients (11.6%) with low SCD risk assessed by the two guidelines had MACE. In this subgroup of patients, multivariate Cox regression analysis showed that global native T1 mapping was independently associated with MACE (HR: 1.532; 95% CI: 1.221–1.922; P &lt; 0.001). In 85 patients with conflicting results assessed by the two guidelines, end-stage systolic dysfunction was independently associated with MACE (HR: 7.942, 95% CI: 1.322–47.707, P = 0.023). In 32 patients with high SCD risk assessed by the two guidelines, NSVT was independently associated with MACE (HR: 9.779, 95% CI: 1.953–48.964, P = 0.006).Conclusion: The global native T1 mapping could provide incremental values and serve as potential supplements to the current guidelines in the prediction of MACE.
Synthetic Peptides Derived From Lycosa Erythrognatha Venom: Interaction With Phospholipid Membranes and Activity Against Resistant Bacteria
Authors: Reis Pablo V. M. , Lima Vinícius M. , Souza Kelton R. , Cardoso Gabriele A. , Melo-Braga Marcella N. , Santos Daniel M. , Verly Rodrigo M. , Pimenta Adriano M. C. , Santos Vera Lúcia dos , de Lima Maria Elena 
Published: June 2021

Superbugs are a public health problem, increasing the need of new drugs and strategies to combat them. Our group has previously identified LyeTxI, an antimicrobial peptide isolated from Lycosa erythrognatha spider venom. From LyeTxI, we synthesized and characterized a derived peptide named LyeTxI-b, which has shown significant in vitro and in vivo activity. In this work, we elucidate the interaction of LyeTxI-b with artificial membranes as well as its effects on resistant strains of bacteria in planktonic conditions or biofilms. Isothermal titration calorimetry revealed that LyeTxI-b interacts more rapidly and with higher intensity with artificial vesicles, showing higher affinity to anionic vesicles, when compared to synthetic LyeTxI. In calcein experiments, LyeTxI-b caused greater levels of vesicle cleavage. Both peptides showed antibacterial activity at concentrations of μmol L−1 against 12 different clinically isolated strains, in planktonic conditions, in a concentration-dependent manner. Furthermore, both peptides elicited a dose-dependent production of reactive oxygen species in methicillin-resistant Staphylococcus aureus. In S. aureus biofilm assay, LyeTxI-b was more potent than LyeTxI. However, none of these peptides reduced Escherichia coli biofilms. Our results show LyeTxI-b as a promising drug against clinically resistant strains, being a template for developing new antibiotics.
Development and Validation of a Semi-Automated, Preclinical, MRI-Template Based PET Image Data Analysis Tool for Rodents
Authors: Schadt Fabian , Israel Ina , Samnick Samuel 
Published: June 2021

AimIn PET imaging, the different types of radiotracers and accumulations, as well as the diversity of disease patterns, make the analysis of molecular imaging data acquired in vivo challenging. Here, we evaluate and validate a semi-automated MRI template-based data analysis tool that allows preclinical PET images to be aligned to a self-created PET template. Based on the user-defined volume-of-interest (VOI), image data can then be evaluated using three different semi-quantitative parameters: normalized activity, standardized uptake value, and uptake ratio.Materials and MethodsThe nuclear medicine Data Processing Analysis tool (NU_DPA) was implemented in Matlab. Testing and validation of the tool was performed using two types of radiotracers in different kinds of stroke-related brain diseases in rat models. The radiotracers used are 2-[18F]fluoro-2-deoxyglucose ([18F]FDG), a metabolic tracer with symmetrical distribution in brain, and [68Ga]Ga-Fucoidan, a target-selective radioligand specifically binding to p-selectin. After manual image import, the NU_DPA tool automatically creates an averaged PET template out of the acquired PET images, to which all PET images are then aligned onto. The added MRI template-based information, resized to the lower PET resolution, defines the VOI and also allows a precise subdivision of the VOI into individual sub-regions. The aligned PET images can then be evaluated semi-quantitatively for all regions defined in the MRI atlas. In addition, a statistical analysis and evaluation of the semi-quantitative parameters can then be performed in the NU_DPA tool.ResultsUsing ischemic stroke data in Wistar rats as an example, the statistical analysis of the tool should be demonstrated. In this [18F]FDG-PET experiment, three different experimental states were compared: healthy control state, ischemic stroke without electrical stimulation, ischemic stroke with electrical stimulation. Thereby, statistical data evaluation using the NU_DPA tool showed that the glucose metabolism in a photothrombotic lesion can be influenced by electrical stimulation.ConclusionOur NU_DPA tool allows a very flexible data evaluation of small animal PET data in vivo including statistical data evaluation. Using the radiotracers [18F]FDG and [68Ga]Ga-Fucoidan, it was shown that the semi-automatic MRI-template based data analysis of the NU_DPA tool is potentially suitable for both metabolic radiotracers as well as target-selective radiotracers.
Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling
Authors: Wang Wei , Xia Xinhang , Chen Kuifei , Chen Meng , Meng Yinnan , Lv Dongqing , Yang Haihua 
Published: June 2021

BackgroundEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective in advanced EGFR-mutation non-small cell lung cancer (NSCLC) but the magnitude of tumor regression varies, and drug resistance is unavoidable. The pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) levels are reduced or lost and acts as a tumor suppressor in many cancers. Here, we hypothesized that PHLPP is a key regulator of EGFR-TKI sensitivity and a potential treatment target for overcoming resistance to EGFR-TKI in lung cancer.MethodsCell proliferation and growth inhibition were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assay. PHLPP- knockdown stable cell lines were generated by lentivirus-mediated delivery of PHLPP shRNAs. The expression of PHLPP mRNA and protein levels was detected by real-time quantitative polymerase chain reaction (qPCR) and Western blotting. Immunohistochemical (IHC) staining was performed to detect the PHLPP expression in clinical patient tissue samples. A transcriptomic assay of genome-wide RNA expressions of PHLPP in NSCLC cell lines according to gefitinib sensitivity was obtained from Gene Expression Omnibus (GEO) database. Murine xenograft model was established to verify the function of PHLPP in gefitinib resistance in vivo.ResultsPHLPP highly expressed in gefitinib-sensitive NSCLC cell lines than gefitinib-resistant NSCLC cell lines. In gefitinib-acquired resistance cell line HCC827-GR, PHLPP expression even dramatically reduced. Knockdown of PHLPP in NSCLC cells decreased cell death induced by the EGFR-TKI, while overexpression PHLPP in gefitinib-resistance NSCLC cells can enhance or restore EGFR-TKIs sensitivity. Mechanism study indicated that PHLPP downregulation attenuates the effect of EGFR-TKI on the both AKT and ERK pathway, thereby decreasing the cell death sensitivity to EGFR inhibitors. In xenograft mice, knockdown of PHLPP decreased tumor response to gefitinib and advanced tumor cells re-growth after gefitinib treatment. In clinical, PHLPP expression were reduced in the post-relapse tumor compared to that of pre-treatment, and lower pre-treatment PHLPP levels were significantly correlated with shorter progression-free survival (PFS) in patients with EGFR-mutant lung adenocarcinoma whom treated with EGFR-TKI.ConclusionsOur data strongly demonstrated that loss of PHLPP function was a key factor of EGFR-TKI resistance in NSCLC. Downregulated PHLPP expression activated PI3K-AKT and MAPK-ERK pathway which strengthened cell survival to EGFR-TKI. Therefore, PHLPP expression level was not only a potential biomarker to predict EGFR-TKIs sensitivity but also as a therapeutic target in EGFR-TKIs therapy, enhancing PHLPP expression may be a valuable strategy for delaying or overcoming EGFR-TKIs drug resistance.
Microconical Structure Formation and Field Emission From Atomically Heterogeneous Surfaces Created by Microwave Plasma–Based Low-Energy Ion Beams
Authors: Majumdar Jayashree , Bhattacharjee Sudeep 
Published: June 2021

We report the formation of self-organized microconical arrays on copper surface when exposed to high flux (5.4 × 1015 cm−2 s−1) of 2 keV argon ion beams at normal incidence. The created microconical arrays are explored for field emission properties. The surface morphologies are investigated by scanning electron microscopy and atomic force microscopy. The local work function variation is analyzed by Kelvin probe force microscopy, and the argon content in the irradiated layer is measured with X-ray Photoelectron Spectroscopy. The average aspect ratio (base width/height) of microstructures for individual irradiated samples is found to increase from 0.7 to 1.5 with a decrease in ion fluence. The ion concentration is highest (3.89 %) for a fluence of 4.7 × 1018 cm−2, which asserts the formation of atomically heterogeneous surface due to subsurface ion implantation. An enhancement in the field emission properties of the argon ion–treated copper substrates at a fluence of 4.7 × 1018 cm−2 with a low turn-on voltage of 2.33 kV and with electron emission current 0.5 nA has been observed. From the Fowler–Nordheim equations, the field enhancement factor is calculated to be 5,561 for pristine copper, which gets enhanced by a factor of 2–8 times for irradiated substrates. A parametric model is considered, by taking into account the modified local work function caused due to structural undulations of the microstructures and presence of implanted argon ions, for explaining the experimental results on the field enhancement factor and emission current.
¿Centralizar o descentralizar el régimen departamental?
Authors: Giannone Loreta Ruth 
Published: June 2021

El presente artículo se concentra en el análisis del debate que moduló la reforma del régimen departamental a través de la indagación de los argumentos de los convencionales por el Partido Demócrata que defendían el régimen en torno a esta figura política y de aquellos que abogaron por su eliminación. El debate articula tres tópicos íntimamente vinculados a la noción federal del régimen de representación política y en torno a dicha dimensión se estructuran en primer lugar, las posiciones sobre las atribuciones y/o funciones de los jefes políticos, en segundo lugar, los vínculos entre el Ejecutivo Provincial y el poder departamental y finalmente, la centralización-descentralización de la policía departamental.
La propuesta recupera los intereses en pugna y las motivaciones subyacentes de los convencionales conservadores que apoyaron una u otra posición, por lo que se describen brevemente las trayectorias de los actores y las ideas que modulaban sus argumentos.
EFFECT OF TRANSFORMATIONAL LEADERSHIP, JOB SATISFACTION, AND ORGANIZATIONAL COMMITMENTS ON ORGANIZATIONAL CITIZENSHIP BEHAVIOR
Authors: PURWANTO AGUS , Purba John Tampil , Bernarto Innocentius , Sijabat Rosdiana 
Published: June 2021

The purpose of this study was to determine and examine the effect of transformational leadership, organizational commitment and job satisfaction on organizational citizenship behavior in high schools in Banten Province. The sample in this study was taken from 220 managers of supply chain management implemented company respondents. Sampling in this study using the Simple Random Sampling technique. The analysis technique used is multiple regression analysis. The results of the analysis and testing show that transformational leadership has a positive and significant effect on organizational citizenship behavior, job satisfaction has a positive and significant effect on organizational citizenship behavior, organizational commitment has a positive and significant effect on organizational citizenship behavior. This study has proven that transformational leadership, Organizational commitment and job satisfaction influence organizational citizenship behavior in supply chain management implemented company
PENGARUH KUALITAS PRODUK DAN KUALITAS LAYANAN TERHADAP KEPUASAN KONSUMEN HOTEL BUKIT SERELO LAHAT
Authors: Darwin Kesuma Darwin Kesuma 
Published: June 2021

Tujuan dalam penelitian ini adalah untuk menganalisis pengaruh Pengaruh Kualitas Produk dan Kualitas Layanan Terhadap Kepuasan Konsumen Hotel Bukit Serelo Lahat. Responden yang digunakan sebanyak 63 orang dan teknik pengambilan sampel menggunakan purposive sampling. Dalam penelitian ini data yang digunakan adalah data primer dan data sekunder yaitu berupa data laporan pelanggan, data penjualan kamar dan data kuisioner yang diberikan kepada responden. Teknis analisis data yang digunakan adalah regresi linier berganda dengan menggunakan bantuan software SPSS ver. 16. Dari hasil penelitian ini dapat disimpulkan bahwa (1)Kualitas produk tidak mempengaruhi kepuasan konsumen pada Hotel Bukit Serelo Lahat dengan nilai sig. variabel X1 sebesar 0.63 > 0; (2) Kulitas layanan memiliki pengaruh yang signifikan terhadap kepuasan konsumen dengan nilai sig. sig. variable X2 sebesar 0.000 < 0.05; (3) Variabel X1 dan X2 secara bersama-sama mampu mempengaruhi kepuasan konsumen dengan nilai sig. sebesar 0.000 < 0.05.
Відтворення елементів садівництва, городництва та рільництва відповідно до історико-етнографічного районування території Музею народної архітектури і побуту у Львові імені Климентія Шептицького
Authors: Horbenko N. Ye. , Maryskevych O. H. , Kurnytska M. P. 
Published: June 2021

Музеї під відкритим небом – одна із найперспективніших форм збереження культурної спадщини народу. До них належить Музей народної архітектури і побуту у Львові імені Климентія Шептицького. Територія Музею поділена на сектори (Бойківщина, Рівнинне Закарпаття, Лемківщина, Гуцульщина, Буковина, Покуття, Західне Поділля, Львівщина та Старе українське містечко, Полісся, Волинь), в яких необхідно зберегти наявні насадження та відтворити автентичну флору згідно з відповідними секторами. На основі літературного аналізу запропоновано доповнити експозиції Музею зонами садівництва, городництва та елементами рільництва відповідних історико-етнографічних секторів. Обґрунтовано значущість комплексного підходу до формування експозиції з включенням відповідної до етнографічного зонування рослинної складової для досягнення композиційної цілісності території, гармонійності сприйняття, достовірності подачі архітектурних об'єктів (експонатів). Розроблено концепцію відтворення культурної флори та озеленення території. Для проєктування та подальшого утримання враховано специфіку об'єктів дерев'яної архітектури, що викладено в універсальних схемах формування насаджень на територіях із різним рельєфом. Проаналізовано особливості розташування елементів на території експозиційних споруд та їх зв'язок із прилеглими насадженнями. Запропоновано широкий асортимент рослин для наповнення етноприродного історичного середовища секторів Музею елементами садівництва, городництва та рільництва. За кожним сектором подано попередню оцінку панівного елемента. Запропоновано сумарну оцінку щодо використання рослин для репрезентації господарювання в історико-етнографічних зонах Музею. Отримані результати роботи свідчать про пріоритетність, складність розміщення та компонування насаджень у окремих зонах. Розроблені рекомендації сприятимуть не тільки збереженню цінних історико-культурних об'єктів Музею, але й слугуватимуть спробою реконструкції ландшафтного середовища, традицій природокористування наших предків, максимально наближених до автентичних.
Influence of Ion–Neutral Damping on the Cosmic-Ray Streaming Instability: Magnetohydrodynamic Particle-in-cell Simulations
Authors: Plotnikov Illya , Ostriker Eve C. , Bai Xue-Ning 
Published: June 2021

Abstract
We explore the physics of the gyroresonant cosmic-ray streaming instability (CRSI) including the effects of ion–neutral (IN) damping. This is the main damping mechanism in (partially ionized) atomic and molecular gas, which are the primary components of the interstellar medium (ISM) by mass. Limitation of CRSI by IN damping is important in setting the amplitude of Alfvén waves that scatter cosmic rays (CRs) and control galactic-scale transport. Our study employs the magnetohydrodynamic (MHD)–particle-in-cell hybrid fluid-kinetic numerical technique to follow linear growth as well as post-linear and saturation phases. During the linear phase of the instability—where simulations and analytical theory are in good agreement—IN damping prevents wave growth at small and large wavelengths, with the unstable bandwidth lower for higher IN collision rates ν
in. Purely MHD effects during the post-linear phase extend the wave spectrum toward larger k. In the saturated state, the CR distribution evolves toward greater isotropy (lower streaming velocity) by scattering off of Alfvén waves excited by the instability. In the absence of low-k waves, CRs with sufficiently high momentum are not isotropized. The maximum wave amplitude and rate of isotropization of the distribution function decrease at higher ν
in. When the IN damping rate approaches the maximum growth rate of CRSI, wave growth and isotropization are suppressed. Implications of our results for CR transport in partially ionized ISM phases are discussed.