bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rotavirus hijacks host gluconeogenesis-related signaling pathway to promote self-replication in Caco-2 cells
Authors: Song Lijun , Zhong Peicheng , Gao Mengyue , Lan Qian , Zhu Xuemei , Chen Jiabo , Chen Yang , Zhou Yujing , Feng Yuxuan , Dai Guiqin , Li Feng , Zhao Wenchang 
Published: January 2021

Abstract
Viruses have evolved mechanisms to usurp the host's metabolic resources for their own biosynthesis and replication, but host's glucose metabolism change after rotavirus (RV) stress remains unclear. The metabolic profile and differential gluconeogenesis analysis was performed by gas chromatography-mass spectroscopy on RV-infected cells.47 potential differential metabolites were identified to verify glycolytic/gluconeogenesis pathway after RV infection. Glucose consumption and key enzymes of gluconeogenesis (glucose 6-phosphatase (G-6-pase) and phosphoenolpyruvate carboxylase (PEPCK)) were further examined by glucose oxidase-peroxidase method and enzyme linked immunosorbent assay. We found the impairment of glucose consumption, G-6-pase and PEPCK activities which promote gluconeogenesis, were tested in RV infected Caco-2 cells. By Western blot analysis, further studies detected the downregulation expression level of SIK2, which was affected by its upstream proteins of downregulated PDK1, AKT and upregulation p-JNK, and as a consequence influenced the function of gluconeogenesis. In short, RV infection altered the glucose consumption in infectious Caco-2 cells and activated the host cellular gluconeogenesis, which was hijacked through p-JNK-PDK1-AKT-SIK2 signaling pathway for its proliferation and replication with accelerating non-sugar substances conversion into glucose.
Development and validation of a prognostic COVID-19 severity assessment (COSA) score and machine learning models for patient triage at a tertiary hospital
Authors: Schöning Verena , Liakoni Evangelia , Baumgartner Christine , Exadaktylos Aristomenis K. , Hautz Wolf E. , Atkinson Andrew , Hammann Felix 
Published: January 2021

Abstract
Background: Clinical risk scores and machine learning models based on routine laboratory values could assist in automated early identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients at risk for severe clinical outcomes. They can guide patient triage, inform allocation of health care resources, and contribute to the improvement of clinical outcomes. Methods: In- and out-patients tested positive for SARS-CoV-2 at the Insel Hospital Group Bern, Switzerland, between February 1st and August 31st (‘first wave’, n=198) and September 1st through November 16th 2020 (‘second wave’, n=459) were used as training and prospective validation cohort, respectively. A clinical risk stratification score and machine learning (ML) models were developed using demographic data, medical history, and laboratory values taken up to three days before, or one day after, positive testing to predict severe outcomes of hospitalization (a composite endpoint of admission to intensive care, or death from any cause). Test accuracy was assessed using the area under the receiver operating characteristic curve (AUROC).Results: Sex, C-reactive protein, sodium, hemoglobin, glomerular filtration rate, glucose, and leucocytes around the time of first positive testing (‑3 to +1 days) were the most predictive parameters. AUROC of the risk stratification score on training data (AUROC = 0.94, positive predictive value (PPV) = 0.97, negative predictive value (NPV) = 0.80) were comparable to the prospective validation cohort (AUROC = 0.85, PPV = 0.91, NPV = 0.81). The most successful ML algorithm with respect to AUROC was support vector machines (median = 0.96, interquartile range = 0.85-0.99, PPV = 0.90, NPV = 0.58).Conclusion: With a small set of easily obtainable parameters, both the clinical risk stratification score and the ML models were predictive for severe outcomes at our tertiary hospital center, and performed well in prospective validation.
Molecular characterization of Cotton leaf curl Multan virus and DNA-satellites complex associated enation leaf curl and yellow vein mosaic disease of hollyhock
Authors: Ashwathappa K.V. , Venkataravanappa V , Nandan M. , Vinaykumar H.D. , Shankarappa K. S. , Reddy M. Krishna , Reddy C.N. Lakshminarayana 
Published: January 2021

Abstract
Hollyhock is one important decorative plant grown in garden beds in different region of the the world. The ornamental plant is susceptible to many diseases caused by diverse pathogens. Among these viral pathogens can cause enormous damage to the ornamental plant. The aim of the present study was identification of begomovirus and DNA sateelites is associated with the yellow vein mosaic and enation leaf curl disease complex of hollyhock. The hollyhock plants showing the typical begomovirus-like symptoms were collected from Pusa campus, New Delhi (India). To know the status of the begomovirus, the total DNA isolated from the infected hollyhock was subjected to PCR amplification using primers specific to the begomovirus. The partial (1.2 kb) genome sequencing of ten hollyhock samples indicates the associated of begomovirus (nucleotide identities is more 95% among themselves). Therefore three representative samples (H1, H2, H3) full-length genome (DNA-A, betasatellite and alphasatellite) was amplified through RCA method. The pairwise comparision of complete genome of the begomoviruses, betasatellites and alphasatellites using Sequence Demarcation Tool (SDT) showed highest nucleotide (nt) identity of 88.0 to 92.7% (DNA-A) with Cotton leaf curl Multan virus, 92.5–96.7% with Ludwigia leaf distortion betasatellite and 90.4 to 93. 2% % with Ageratum enation alphasatellite. Further recombinantion analysis showed that the begomoviruses and DNA satellites under study was recombinants of previously reported begomoviruses and DNA sattelites. This is the first report of Cotton leaf curl Multan virus and DNA satellites associated complex disease of hollyhock in India.
Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?
Authors: Vegvari Carolin , Giardina Federica , Bajaj Sumali , Malizia Veronica , Hardwick Robert J. , Truscott James E , Montresor Antonio , de Vlas Sake J , Coffeng Luc E , Anderson Roy M 
Published: January 2021

Abstract
Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One goal of the World Health Organization’s (WHO) 2030 roadmap for neglected tropical diseases is to reduce STH-related morbidity in WRA. As a minimal intervention the WHO recommends deworming adolescent girls annually during human papilloma virus vaccination programmes and women of reproductive age (WRA) during pregnancy and lactation. These routine interventions are low cost can be implemented even from the most basic health services in endemic countries. In this study we use a cohort model to investigate the potential impact on STH-related morbidity in WRA.Results: Annual deworming treatment of adolescent girls reduces the prevalence of moderate- and heavy-intensity infections in this age group by up to 60% in moderate transmission settings and by 12-27% in high-transmission settings. Treatment of WRA during pregnancy and lactation on its own has a small (<20%) but significant effect on morbidity although it does not lead to the achievement of the morbidity target (<2% moderate-to-high intensity infections) in this age group. However, depending on the age-intensity profile of infection, which may vary geographically, and assumptions on the density-dependence of egg production by fertilised female worms, continued school-based treatment may be able to reduce the force of infection acting on WRA, both through an indirect effect on the overall population based force of infection and via reducing the burden of infection as children age and move into the WRA age classes. As a result, morbidity in WRA may be eliminated.Conclusion: While deworming during pregnancy and lactation does not lead to the achievement of the morbidity target in WRA and its efficacy may vary by setting, it is still expected to be beneficial for maternity and child health. Monitoring of any WRA-based intervention is recommended to evaluate its effectiveness.
Studying the effect of carbon dioxide oil solubility on asphaltene aggregation under conditions of the Bashkortostan Republic fields
Authors: Shayakhmetov A. I. , Malyshev V. L. , Moiseeva E. F. , Ponomarev A. I. , Zeigman Yu. V. 
Published: January 2021

The purpose of this work is to study the effect of carbon dioxide oil solubility on the aggregation of asphaltene associates and decrease of oil permeability of sandstones. Consideration is given to the interaction variants of oil and carbon dioxide in a free volume before being injected into a porous medium and immediately in the porous medium. The influence of oil composition on the aggregation of asphaltene associates is studied. The effect of the dissolved carbon dioxide on associate dispersion in oil is examined through oil filtering in sandstones. If asphaltene aggregation occurs in a porous medium it causes pore plugging leading to reduced permeability, complicates the development of carbon dioxide injection wells and, as a result, prevents from achieving the planned indicators of oil production and oil recovery. It is found that in the case when oil interacts with carbon dioxide in the free volume before being injected into a porous medium, the increase in the volume of filtered oil and the concentration of carbon dioxide dissolved in oil, and decrease in sandstone permeability reduce the relative mobility of oil with the dissolved carbon dioxide. The significant influence of sandstone permeability on the experimental results indicates that the sizes of asphaltene aggregates are comparable to the sizes of small pores. We have not observed complete attenuation of filtration after passing of oil with dissolved carbon dioxide through sandstones. Based on the analysis of changes in oil composition and properties carried out in the laboratory experiments on oil displacement by carbon dioxide rims, it has been determined that aggregation of asphaltene associates takes place under immediate contact of oil and carbon dioxide in a porous medium. The higher the asphaltene content in oil, the lower the formation permeability, whereas tight formations feature a more significant decrease in permeability.
Development of regulatory requirements for universal banks in the process of implementing a new standardized approach to credit risk assessment
Authors: Волкова Е.К. 
Published: January 2021

В статье анализируются основные изменения регулятивных требований в части снижения коэффициентов кредитного риска при расчете универсальными банками норматива достаточности капитала. Обосновываются своевременность указанных изменений и возможности их дальнейшего развития. Введение в действие в 2020 году пониженных коэффициентов риска при расчете норматива достаточности капитала вызвано необходимостью стимулирования кредитования реального сектора экономики. Автором даны рекомендации по дальнейшему развитию подходов Банка России к корректировке регулятивных требований к банкам в части присвоения пониженных коэффициентов риска при кредитовании заемщиков реального сектора экономики.
The article analyzes the main changes in regulatory requirements in terms of reducing credit risk ratios when calculating the capital adequacy ratio by universal banks. The author substantiates the timeliness of these changes and the possibility of their further development. The introduction of reduced risk factors in the calculation of the capital adequacy ratio in 2020 is due to the need to stimulate lending to the real sector of the economy. The author provides recommendations for further development of the Bank of Russia's approaches to adjusting regulatory requirements for banks in terms of assigning reduced risk factors for lending to borrowers in the real economy.
Personnel problem and ways to solve it based on consolidated interaction interested parties
Authors: Измайлова М.А. 
Published: January 2021

Статья посвящена анализу сложившейся кадровой проблемы в российских компаниях: компании не могут найти нужных специалистов, а соискатели - работу. Показаны актуальные тенденции российского рынка труда и варианты его развития в среднесрочной перспективе. Дано описание портрета современного соискателя вакантных позиций на российском рынке труда. Проведен анализ моделей поведения основных участников рынка труда. Делается вывод о необходимости объективизации процесса поиска профессионалов с участием всех заинтересованных сторон.
The article is devoted to the analysis of the current personnel problem in Russian companies: companies can't find the right specialists, and job seekers can't find a job. Current trends in the Russian labor market and options for its development in the medium term are shown. The description of the portrait of a modern applicant for vacant positions in the Russian labor market is given. The analysis of behavior models of the main participants of the labor market is carried out. It is concluded that it is necessary to objectify the process of searching for professionals with the participation of all interested parties.
Analysis of the current state of the investment relations between Russia and India
Authors: Красавина Л.Н. , Хомякова Л.И. 
Published: January 2021

Статья посвящена анализу длительного сотрудничества России и Индии в инвестиционной сфере. Объектом исследования стали инвестиционные связи между данными государствами. На основании российской и индийской статистики, а таакже статистики международных организаций сделаны выводы о неравномерности распределения прямых иностранных инвестиций России и Индии, указано на их различное положение в международном движении капитала. Приведены примеры конкретных инвестиционных проектов между ТНК двух стран. Обоснованы выводы о недостаточном использовании потенциала российско-индийских инвестиционных отношений и даны предложения по их активизации.
The article is devoted to the analysis of the long-term cooperation between Russia and India in the investment sphere. The object of the study was the investment relationships between these states. Based on the Russian and Indian statistics, as well as on the statistics of the international organizations, conclusions are given about the uneven distribution of foreign direct investment between Russia and India, their different position in the international capital flow is indicated. Examples of specific investment projects between TNCs of the two countries are given. The conclusions about the underutilization of the potential of Russian-Indian investment relations are substantiated and proposals for their activation are given.
Business culture in spots entrepreneurship
Authors: Ильин А.Б. , Сизова Ю.С. 
Published: January 2021

В статье определяются принципы предпринимательской культуры спортивного бизнеса на основе определения моральных и этических аспектов социально ориентированной деятельности спортивных организаций, приводится определение понятия предпринимательской культуры; выделяются 3М уровни ее развития в экономике. В том числе в данной работе представлено соотношение жизненного цикла организаций со спортивной отраслью; выделены принципы предпринимательской пластичности спортивного бизнеса; приведены примеры спортивной этики спортивного бизнеса. В качестве методического аппарата исследования используются исходные модели экономической науки; теории жизненных циклов организации; теории предпринимательской культуры. Впервые в теории экономики предпринимательства выделена категория «предпринимательская пластичность», под которой авторы понимают функцию бизнеса по реагированию на ключевые моральные и этические принципы предпринимательски-социально-ориентированных видов деятельности, их сохранение, соблюдение, адаптацию и масштабирование.
The paper defines sports business culture principles in terms of moral and ethical aspects defining of sports organizations socially oriented activities; provides the definition of entrepreneurial culture concept; specifies 3M levels of its development in the economy. Moreover, the correlation of organizations life cycle with the sports industry is presented; the principles of entrepreneurial plasticity of the sports business are highlighted; examples of sports ethics of the sports business are given. As for the methodological apparatus of the study, the initial models of economic science are used; organization life cycle theory; theory of entrepreneurial culture. For the first time in the theory of business economics, the category of “entrepreneurial plasticity” has been singled out, by which the authors understand the function of a business in responding to key moral and ethical principles of entrepreneurial and socially oriented activities, their preservation, compliance, adaptation, and scaling.
Technology for modeling and integrated assessment of regional security indicators
Authors: Маслобоев А.В. 
Published: January 2021

Для задач синтеза сценариев управления региональной безопасностью в условиях кризисных ситуаций разработана технология интегральной оценки безопасности региональных социально-экономических систем. Предложена формализованная постановка задачи и ее декомпозиция с учетом набора ключевых показателей безопасности. В отличие от известных формальных моделей устойчивого развития технология обеспечивает формирование матричного интегрального показателя региональной безопасности и позволяет оценить состояние и тенденции развития региона за счет совместного использования системно-динамических, нечетких и вероятностных моделей оценки индикаторов безопасности. С применением разработанной технологии построена матрица региональной безопасности Арктической зоны РФ.
For management scenario synthesis of regional security under emergency situations problem-solving a technology for security integral estimation of the regional socio-economic systems has been developed. The formalized problem statement and it decomposition subject to the set of key security indicators have been proposed. In contrast to well-known and state-of-the-art formal models of sustainable development the technology provides matrix integral index formation of regional security and allows situation and tendencies assessment of regional development at the expense of joint use of system-dynamic, fuzzy and probabilistic estimation models of security indicators. With application of developed technology the regional security matrix of Arctic region of Russian Federation has been designed.
Accuracy of measurement of the signal information parameter in aviation and space-rocket radio systems in the presence of additive and multiplicative interference with a low level
Authors: Артюшенко В.М. , Воловач В.И. 
Published: January 2021

Рассмотрено и проанализировано влияние флуктуационных стационарных мультипликативных помех, действующих одновременного с аддитивными помехами, на точность измерения неэнергетических параметров информационных сигналов. Показано, что при низком уровне мультипликативных и аддитивных помех оценка одного параметра полезного сигнала оказывается несмещенной, а ее дисперсия представляет сумму двух слагаемых, первое учитывает влияние аддитивных помех, второе - мультипликативных. Наиболее опасными являются медленные мультипликативные помехи.
The influence of fluctuating stationary multiplicative interference acting simultaneously with additive interference on the accuracy of measurement of non-energy parameters of information signals is considered and analyzed. It is shown that at a low level of multiplicative and additive interference, the estimation of one parameter of the useful signal is unbiased, and its dispersion is the sum of two terms, the first takes into account the influence of additive interference, the second - multiplicative. Slow multiplicative interference is the most dangerous.
Assessment of the effectiveness of import substitution in the aerospace segment of the military-industrial complex taking into account risk minimization
Authors: Ушакова К.О. , Исаев В.Г. 
Published: January 2021

В 2014 году странами НАТО были введены ограничения на поставку импортного оборудования и комплектующих в Российскую Федерацию. В связи с чем была актуализирована проблема национальной безопасности, решение которой требует разработки и применения целого комплекса мер - экономических, организационных и правовых. Государство впервые за много лет столкнулось с реальной необходимостью импортозамещения. Вопросы импортозамещения являются стратегически важными, от их решения зависит обеспечение обороноспособности национальной экономики. Государство перешло к стратегии импортозамещения и поддержке отечественного производителя.
In 2014, Russian Federation was restricted in importing of foreign equipment and component parts by countries that were NATO members. In that situation, the importance of national security issues increased. To deal with those issues, a range of different measures such as economical, organizational and legal were to be applied. After a long time, once again Russian Federation faced the problems concerning import substitution. National security issues are strategically important, solving these issues effects national economics defense potential. Russian Federation followed the import substitution strategy and started to support domestic producers.
Design features of decision support systems with adaptation elements
Authors: Акимкина Э.Э. 
Published: January 2021

Рассмотрены вопросы повышения эффективности систем поддержки принятия решений на основе многомерных хранилищ данных, имеющие существенное значение для выполнения требований по увеличению быстродействия систем. Показано, что эффективность функционирования системы поддержки принятия решений возрастает при введении в нее элементов обслуживания, которые позволяют учитывать изменение условий внешней и внутренней среды. Разработана методика проектирования системы поддержки принятия решений, учитывающая особенности ее адаптации к изменяющимся условиям с помощью элементов обслуживания.
Issues of increasing the effectiveness of decision support systems based on multidimensional data warehouses are considered, which are essential for fulfilling the requirements to increase system performance. It is shown that the effectiveness of the functioning of the decision support system increases with the introduction of service elements in it, which allow taking into account changes in the conditions of the external and internal environment. A methodology has been developed for designing a decision support system that takes into account the peculiarities of its adaptation to changing conditions using service elements.
Computer modeling of parametric converters with frequency and phase control
Authors: Иванов В.В. , Еремина Я.В. , Ермолова С.В. 
Published: January 2021

Осуществлено математическое моделирование параметрических преобразователей, использующих режим повышенной чувствительности. Названный режим преобразователей позволяет повысить эксплуатационные показатели аппаратуры авиационно-космических систем. Показано, что преобразователи с фазовым управлением обладают линейными характеристиками и являются более перспективны. Применение в них цифровых фильтров ведет к повышению стабильности частоты и точности настройки, а также минимизируется погрешность характеристики преобразования.
Mathematical modeling of parametric converters using high-sensitivity mode is carried out. The named mode of converters allows to increase operational parameters of the equipment of aerospace systems. It is shown that phase-controlled converters are more promising because they have linear characteristics and allow the use of digital filters, which leads to an increase in frequency stability and accuracy of adjustment, and also minimizes the error of the conversion characteristic.