bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suprachoroidal hemorrhage associated with pars plana vitrectomy
Authors: Mo Bin , Li Song-Feng , Liu Yi , Zhou Jun , Wang Shao-Li , Shi Xiang-Yu 
Published: March 2021

Abstract
Purpose
To analyze the characteristics, related risk factors, and prognosis of suprachoroidal hemorrhage (SCH) associated with pars plana vitrectomy (PPV).
Methods
Cases of SCH associated with PPV excluding trauma were retrospectively analyzed in Beijing Tongren Hospital between January 2010 and June 2020. General data were collected including general data, myopia status, axial length, state of crystalline lens, onset time of SCH, range, treatment method, visual prognosis, and methods of operation and anesthesia. Patients were divided into those with SCH related to first PPV (Group 1), and SCH related to second intraocular surgery in vitrectomized eye (Group 2). Patients were also categorized by the onset time of SCH as expulsive suprachoroidal hemorrhage group (ESCH), and delayed suprachoroidal hemorrhage group (DSCH).The general data, related risk factors, and the visual prognosis of SCH in different groups were analyzed.
Results
SCH associated with PPV was studied in 28 cases; 16 male and 12 female. The mean age of the patients was (53.51 ± 10.21) years old, and the mean follow-up time (24.94 ± 14.60) days, mean axial length was (28.21 ± 3.14) mm. Of these cases, 21 was high myopia, 25 was aphakia/ pseudophakic, and 7 had focal hemorrhage. Silicone oil removal had the highest occurrence with 12 cases (43%). Patients in Group 2 were younger than Group 1 (P = 0.005). In terms of treatment and prognosis, 5 eyes were simply closely observed, 4 given single suprachoroidal drainage, 15 given suprachoroidal drainage combining silicone tamponade, 2 undergoing anterior chamber puncture, and 2 giving up treatment. A follow-up vision: NLP ~ 20/30; 2 eyes with NLP (7.14%), 6 of ≥ 20/200 (21.43%). The final outcomes presented a significantly positive correlation with baseline vision, but no significant correlation with age or axial length.
Conclusions
SCH has a higher incidence rate after a second intraocular surgery in a vitrectomized eye which is associated with the lack of vitreous support and easier fluctuation of intraocular pressure. SCH associated with PPV is more localized and has a relatively good prognosis; high myopia and aphakic/ pseudophakic eyes are risk factors. Active treatment can effectively improve visual prognosis.
Trial registration:
Retrospective case series study, not applicable.
Molecular Evolution of Alphabaculovirus genomes: Evidence of Mutational bias and Natural selection
Authors: Mahapattanakul Puttatida , Rajbhandari Pragun , Rodpothong Patsarin 
Published: March 2021

Abstract
Codon usage is a reflection of evolutionary adaptation to environmental pressure. The pattern of usage may be unique to species of viruses, genomes of the same species or genes within the same genome. Here we have analysed the overall nucleotide composition and the nucleotides at different codon positions in the genomes of 6 Alphabaculoviruses. Principle Component Analysis (PCA) based on Relative Synonymous Codon Usage (RSCU) of all Open Reading Frames (ORFs) was employed to investigate the pattern of the codon usage. The results suggest the Alphabaculovirus genomes, except that of Agrotis Ipsilon mNPV (AgipNPV), are predominantly under an influence of a neutral mutation that bias toward A/T. The majority of the ORFs, except those of the AgipNPV, cluster at the same location in the 2-dimensional PCA map with one prominent outlier that has been identified as a P6.9 gene. The six Alpha-baculovirus P6.9 genes have a high G/C content, dissimilar to the majority of the ORFs. The G/C content is found to be significantly high at the 2 nd codon position, suggesting the influence of natural selection and perhaps reflecting its functional conservation in DNA packaging as well as its evolutionary relation to Protamine.
Probing the Private Quantum Life of s Electrons in Atoms of Nanomaterials -A New Quantum Theoretical Insight
Authors: IYAKUTTI KOMBIAH , VJ Surya , Y Kawazoe 
Published: March 2021

Abstract
The exotic properties exhibited by some of the nanomaterials could not be explained by the existing quantum theory. As a result one is forced to look back at the development of the quantum theory and some of the inelegancies. First, the quantized orbital angular momentum of s electron in an atom is taken as zero. This may be an acceptable fact for s electrons in an individual atom, but for the s electrons in a crystal or nanomaterial, this is far from the real situation. Secondly, in the wave function Ψ(r,θ), θ is considered as a dimensionless variable. These inelegancies lead to the impression that the present quantum theory is a steppingstone to a more complete description of nature. Here arises a necessity for probing the private quantum life of s electrons in crystal or nanomaterial. By assigning dimension to θ on par with r, we have quantum engineered the orbital angular momentum and hence the orbital degrees of freedom of s electrons and their signatures in a crystal. This restoration leads to new non-zero angular quantum numbers to s electrons of atoms in a crystal/nanomaterial. As a result the s electron occupation in nanomaterial is altered. Its new physics implications in material science, quantum chemistry and quantum technology are highlighted in this paper.
Characterization, Cultivation, and Chloroplast Genome Analysis of Betula Fujianensis
Authors: Gao Wei , Huang Yongrong , Wang Huihui , Huang Shide , Ye Gongfu , Huang Maogen , Wu Xingsheng , Chen Aiping , Xiao Shengwu , Zhang Hangxiao 
Published: March 2021

Abstract
Background: Betula fujianensis (B. fujianensis), a new Betulaceae species reported in 2008, is endemic and endangered in the Fujian province of China. However, little is known about it, and no special protection measures have been taken. So it is urgent to take some activities for its well conservation.Results: In this study, we systematically described its morphological characteristics, developed a cultivation method, and were the first to report its whole chloroplast genome sequence. We conducted a comparative analysis using its synonymous species (B. luminifera) and identified its distinct characteristic, especially in bark and leaves. It has serrated leaves covered with glandular punctation and short and rare pubescences, and its bark gradually changes with age from smooth to exfoliate. We also observed that its chlorophyll content substantially changes with age. Furthermore, we also sequenced B. luminifera’s chloroplast genome sequence, compared it with that of B. fujianensis, and found that gene rpl16 is absent in B. fujianensis. Phylogenetic analysis also showed that B. fujianensis is relatively close to B. luminifera. Conclusions: These observations and chloroplast genome sequence results provide more information about B. fujianensis. The comparative analysis with B. luminifera will provide some clues to different environmental adaptation. The cultivation method make further scientific researches possible, contribute to its good conservation and promote its utilization in afforestation and industrial application in the future.
In-birth CPR in neonates; Predictable or Unpredictable?
Authors: Zarkesh Mohammad Reza , Moradi Raheleh , Orooji Azam 
Published: March 2021

Abstract
Background: Anticipating on in-birth Cardiopulmonary Resuscitation(CPR) in neonates is very important and complex. Timely identification and rapid CPR in neonates in the delivery room significantly affect reducing the mortality and other neurological disabilities. The aim of this study is to create a prediction system for identifying the need to in-birth CPR in neonates based on Machine Learning(ML) algorithms.Methods: In this study, 3882 neonatal medical records were retrospectively reviewed. Records were extracted from the maternal, fetal, and neonatal registry of Valiasr hospital in Tehran. A total of 60 risk factors were extracted, and five ML algorithms including J48, Naïve Bayesian, Multilayer Perceptron (MLP)، Support Vector Machine (SVM) and Random Forest were compared to predict the need to in-birth CPR in neonates. Also, using 10 feature selection algorithms, the features were ranked based on the importance, and using the ML algorithms, the important risk factors were identified. Results: In order to predict the need to in-birth CPR in neonates, SVM using all risk factors reached the accuracy of 88.43% and F-measure of 88.4%, while MLP using the 15 first important features reached the accuracy of 90.86% and the F-measure of 90.8%. The most important risk factors included gestational age, delivery type, presentation, steroid administration, macrosomia, prenatal care, infant number and rank, mother addiction, maternal chronic disease history, fetal hydrops, amniotic fluid, gestational hypertension, infertility and placental abruption. Conclusions: The proposed system can be useful in predicting the need to CPR in neonates in the delivery room.
A Study on the Efficacy and Safety of a New Endoscopic Nasal Mask for Intravenous Anaesthesia With Respiratory Retention: a Randomized Controlled Trial
Authors: Yu Bin , Wang Mengying , Cheng Xinyu , Ma Haiyue , Xie Shuqi 
Published: March 2021

Abstract
Background: General anaesthesia is the most common choice for day surgery, and a laryngeal mask airway is the most commonly used airway management method in general anaesthesia. Many of the complications of laryngeal mask airways are not conducive to a rapid recovery and discharge. The main purpose of this study was to verify the effectiveness and safety of a new endoscopic nasal mask for anaesthesia for a short surgery.Methods: This is a randomized controlled study of 96 patients who were scheduled to undergo hysteroscopy, breast mass resection or great saphenous vein lesion resection. They were randomly divided into two groups. After entering the operating room, 48 patients in the control group were treated with LMA-assisted ventilation, and 48 patients in the experimental group were subjected to assisted ventilation with the new endoscopic nasal mask. Both groups were given dexmedetomidine combined with sufentanil, propofol, dexamethasone, parecoxib sodium, dezocine and ramosetron to complete the intravenous general anaesthesia.The main observation indexes included the occurrence of hypoxemia (SpO2<90%) after anaesthesia induction; the occurrence of hypercapnia (PetCO2>50 mmHg) due to respiratory depression and changes in the PaO2 and PaCO2 values in the arterial blood gas analysis (ABG) results.Results: The occurrence of hypoxemia (SPO2<90%) in the experimental group and the control group was not significantly different (P>0.05). The occurrence of hypercapnia (PetCO2>50 mmHg) in the experimental group was significantly reduced compared to that in the control group (P<0.05), and the difference was statistically significant. According to the results of the preoperative and postoperative arterial blood gas analysis, there was no statistically significant difference in PaO2 and PaCO2 between the two groups (P>0.05). Conclusion: Both methods are safe and effective for anaesthesia during a short operation. The new endoscopic nasal mask can quickly and effectively provide effective ventilation . It is convenient for anaesthesia airway management for clinical short day surgery.Trial registration: Trial Registration: www.chictr.org.cn; registration no.: ChiCTR2000032548; date of registration: 3rd May 2020
18f-fdg Pet/mr in Focal Epilepsy: a New Step for Improving the Detection of Epileptogenic Lesions
Authors: FLAUS Anthime , MELLERIO Charles , RODRIGO Sebastian , BRULON Vincent , LEBON Vincent , CHASSOUX Francine 
Published: March 2021

Abstract
Purpose: Hybrid PET/MR is a promising tool in focal drug-resistant epilepsy, however the additional value for the detection of epileptogenic lesions and surgical decision-making remains to be established.Methods: We retrospectively compared 18F-FDG PET/MR images with those obtained by a previous 18F-FDG PET co-registered with MRI (PET+MR) in 25 consecutive patients (16 females, 13-60 year-old) investigated for focal drug-resistant epilepsy. Visual analysis was performed by two readers blinded from imaging modalities, asked to assess the technical characteristics (co-registration, quality of images), confidence in results, location of PET abnormalities and presence of a structural lesion on MRI. The clinical impact on surgical strategy and outcome was assessed independently.Results: The location of epilepsy was temporal in 9 patients and extra-temporal in 16 others. MRI was initially considered negative in 21 of them. PET alone demonstrated metabolic abnormalities in 19 cases (76%), and the co-registration with MRI allowed the detection of 4 additional structural lesions. PET/MR was considered better performing than PET+MR in 56% of patients. The increase in sensitivity was 13% and new structural lesions (mainly focal cortical dysplasias) were detected in 6 patients (24%). Change of surgical decision-making was substantial for 40% of patients, consisting in avoiding invasive monitoring in 6 patients and modifying the planning in 4 others. Seizure-free outcome was obtained in 13/14 patients who underwent a cortical resection.Conclusion: Hybrid PET/MR improves the detection of epileptogenic lesions, allowing to optimize the presurgical work-up and to increase the proportion of successful surgery even in the more complex cases.
Tool Wear Conditions Monitoring Based on Kernel Smoothing Density and Deep Learning
Authors: BAZI Rabah , Benkedjouh Tarak , Habbouche Houssem , Rechak said 
Published: March 2021

Abstract
Life prediction and health assessment of cutting tools is a challenging problem in industrial manufacturing, and plays an important role for Prognostic activities. The degradation of this tool can cause significant economic losses and risks for machine users. However, due to the random nature of system degradation and the sensitivity of various features characterizing cutter degradation, may vary considerably under different operation conditions. This paper propose a new data driven approach for tool condition monitoring, based on kernel smoothing density to model the random phenomena of degradation progression. The health assessment is insured using one directional neural network to extract useful information’s. Deep learning allows relating between extracted features and health indicator progression, and estimate remaining useful life. This methodology is evaluated using regression metrics and compared with recent frameworks, based on an experimental dataset from PHM Data Challenge 2010. The obtained results shows that the proposed approach can effectively predict the tool wear and obtain higher prediction accuracy than other comparison models.
Dissemination of Blandm-5 in Escherichia Coli via the Incx3 Plasmid From Different Regions in China
Authors: Hu Xiaofeng , Yang Lang , Dong Nian , Lin Yanfeng , Zhang Ling , Wang Xu , Guo Xudong , Xiang Ying , Jin Lianqun , Zhang Chuanfu , Sun Yansong , Li Peng , Song Hongbin , Shaofu Qiu 
Published: March 2021

Abstract
Background: Recently, the spread of NDM-5-producing Escherichia coli has become a severe challenge in clinical therapy, which necessitates reliable detection and surveillance methods. However, limited information is available regarding the prevalence and dissemination of the blaNDM-5 gene in Escherichia coli in China. Therefore, we investigated the dissemination of the blaNDM-5 gene in carbapenem-resistant Escherichia coli isolates from different regions in China.Methods: A total of 1,180 carbapenem-resistant enterobacteriaceae strains were obtained from patients admitted to the 20 sentinel hospitals in eight cities. Strains positive for blaNDM-5 were detected using the Vitek 2 compact system, 16S rRNA gene sequencing, PCR, the S1-pulsed-field gel electrophoresis assay, and Southern blot hybridization. The horizontal-transfer capability of the blaNDM gene was assessed by filter mating with a standard E. coli J53 azide-resistant strain as the recipient. Genotyping, susceptibility testing, and whole genome sequencing were performed. Results: Seven strains of blaNDM-5-positive E.coli was detected in 1180 clinical strains from different regions in China. The blaNDM-5-carrying strains showed resistance to multiple tested antibiotics and belonged to two widespread sequence types, ST167 and ST405. Antimicrobial resistance genes including blaCTX-M, blaOXA, blaCMY, and two novel blaTEM variants (blaTEM-230 and blaTEM-231) were also identified. Southern blotting located the blaNDM-5 gene on 46-kb IncX3 plasmids in all isolates, which showed only two single nucleotide differences between EJN003 and the other strains. Conclusions: This study further confirms the increasing occurrence of blaNDM-5-carrying IncX3 plasmids and the dissemination of carbapenem resistance in E. coli isolates via the plasmid from different parts in China, which warrants stringent surveillance and control measures.
Rps15a Imparts Chemoresistance by Regulating Cd44 Expression and Cell Stemness in Esophageal Squamous Cell Carcinoma
Authors: Zhou Pengjun , Wang Xiaoping , Li Ziyao , Wang Yifei , Zhang Rong 
Published: March 2021

Abstract
Chemotherapy is one of the effective ways to treat esophageal squamous cell carcinoma (ESCC), but the development of chemoresistance during chemotherapy lowers drug efficacy. Although previous studies have shown that the ribosomal protein S15A (RPS15A) involved in the progression and overall survival of malignancies, its function in chemoresistance is unknown. This study sought to elucidate the function of RPS15A in chemoresistance in ESCC. Our results show that knocking down or overexpressing RPS15A in ESCC cell lines can significantly change the sensitivity of chemotherapeutic drugs and affect cisplatin-induced apoptosis. Moreover, an increase in chemotherapeutic drug concentration leads to increased expression of RPS15A and CD44 proteins. When we utilized the ESCC cisplatin-resistant cell line to corroborate our findings, we found that the levels of RPS15A and CD44 proteins were substantially greater in daughter than parental cells. Subsequent experiments indicated that RPS15A modulated chemoresistance by controlling the expression of CD44 and the cell stemness in ESCC. Hence, our data suggest that RPS15A participates in the chemoresistance in ESCC by controlling the expression of CD44 and regulating cell stemness. Taken together, our study provides plausible mechanisms for RPS15A-mediated chemoresistance in ESCC cells and suggests that the inhibition of the RPS15A/CD44 pathway may be a potential target for improving chemotherapy efficacy.
Parental decision and intent towards COVID-19 vaccination in children with asthma. An econometric analysis
Authors: Drouin Olivier , Montmarquette Claude , Prudhomme Alexandre , Arnaud Yann , Fontaine Pierre , Silva Roxane Borgès Da 
Published: March 2021

Abstract
Objective

. Vaccination will be instrumental in controlling the COVID-19 pandemic, and vaccination of children will be necessary to achieve herd immunity. Given that children with chronic health conditions may be at increased risk of COVID-19, it is crucial to understand factors influencing parental decisions about whether to have their child vaccinated. The study objectives were to measure parental intent to have their child with asthma vaccinated against COVID-19 and identify the determinants of their vaccination decision.
Study design

. This study is based on a cross-sectional exploratory observational online survey assessing parents' risk perception in the context of COVID-19.
Methods

. In this study conducted in August 2020, the primary outcome was parent’s answer to the question on their intention to get their child vaccinated if a vaccine against COVID-19 was available. Participants were also asked about their intention to get vaccinated themselves. Independent variables studied included sociodemographic, clinical data (e.g. presence of other chronic diseases), psychological, cognitive and risk perception related to COVID-19. Simultaneous equations models (3SLS) and seemingly unrelated regressions model (SUR) were carried out to identify factors associated with intention to have the child vaccinated and participants’ intention to get vaccinated themselves against COVID-19.
Results
.
A total of 305 participants completed
the survey.

Overall, 19.1% of participants reported being unlikely or very unlikely to vaccinate their child against COVID-19 if a vaccine was available. Similarly, 21.0% were unlikely or very unlikely to get vaccinated themselves. The following factors were significantly (p ≤ 0.05) associated with parents’ decision to have their child vaccinated: parental level of education, employment status, sex of the child, presence of other chronic diseases, whether or not the child had been vaccinated against influenza in the past, parental anxiety, and consultation with a health professional since the beginning of the pandemic. There was a strong relationship between likelihood of not intending to have one’s child vaccinated and personal intent not to get vaccinated.
Conclusion

. These findings are essential in planning for the communication and dissemination of COVID-19 vaccination information to parents, especially for children with asthma or other chronic medical conditions.
Novel and Accurate Predictive Model of Peri-implantitis for Implant Prosthesis in Managing Patients With Chronic Periodontitis
Authors: Lu Jiaping , Zhang Naizheng , Qian Wenhao 
Published: March 2021

Abstract
The aim of this study was to identify the influencing factors of peri-implantitis for implant prosthesis and to establish a predictive model of occurrence in managing patients with chronic periodontitis. 430 patients (a total of 686 implants) with 5 years follow-up were included in the study. The demographic and clinical characteristics independent variables were including patient related factors (age, gender, duration of symptoms, smoking, diabetes, severity of periodontitis, bone mineral density, oral hygiene) and implants related factors (position, implant diameter, implant length, additional operations, probing depth, gingival index, plaque index, load-bearing time). Univariate analysis identified the influencing factors, the statistically significant factors were further analyzed by multivariate logistic regression, and the predictive model was established. After 5 years of follow-up, peri-implantitis occurred in 95 of 686 implants (13.8%). Multiple linear regression indicated that smoking (p = 0.011), diabetes (p < 0.001), severe periodontitis (p = 0.023), lager implant diameter (p < 0.001) and poor oral hygiene (p < 0.001) increased the odds of occurrence of peri-implantitis. There were no significant differences in other factors. (p > 0.05) Logistic regression drew the equation: occurrence of peri-implantitis = [1 + e (16.172+5.395*smoking+4.807*diabetes +8.109*severe periodontitis+5.569*lager implant diameter+11.138*poor oral hygiene)]−1. The sensitivity of predictive factors was 91.77%, 88.43%, 82.64%, 85.21% and 92.02%, respectively. The specificity 45.65%, 49.17%, 66.23%, 42.39% and 65.41%, respectively. The AUC was 0.721, 0.620, 0.453, 0.651 and 0.826, respectively. Hosmer-Lemeshow test showed a good fitting of the predictive model with an overall accuracy of 87.2%. Smoking, diabetes, severe periodontitis, lager implant diameter and poor oral hygiene are important risk factors of peri-implantitis. We also established a novel and accurate predictive model for the occurrence of peri-implantitis in managing patients with chronic periodontitis. The use of these parameters, in the form of a predictive model, has the potential to improve decision-making in the application of the treatment plan.