bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Inhibition Characteristics of Electrical Trees by the Synergistic Effect of Layered MMT and Spherical SiO2 in PE
Authors: Wang Yulong , Liu Tongjiang , Li Lili , Wang Meng , Li Jiangxu , Ma Congcong , Gao Junguo , Guo Ning 
Published: December 2024

ABSTRACTIn power equipment insulations subjected to prolonged high‐field conditions, the formation of electrical trees is a common occurrence, significantly impacting the service life and operational reliability of the equipment. In this paper, PE composites were prepared by melt blending method using layered nano‐MMT and spherical nano‐SiO2 as fillers to enhance the suppression of electrical trees. The microscopic properties of PE composites were characterized by scanning electron microscopy (SEM), polarizing microscopy (PLM), (DSC). The electrical tree of composites was conducted by the electrical tree test system. Subsequently, the synergistic inhibition of PE by nanoparticles with different morphologies was investigated. Key insights derived from the experimental findings are as follows: first, when MMT is doped with PE, due to the layered structure characteristics, the electro‐acoustic coupling effect, and the coulomb blockade effect, the complexity and complicacy of electron motion trajectory are increased, then the breakdown field strength EB of MMT/PE is increased by 5.74% compared with PE. Thus, the length of electrical trees at the retardation stage decreased by 175 μm, and their morphology changed from branch to bushy branch. Second, when layered MMT and spherical SiO2 are doped in PE simultaneously, the electron travel becomes more complex and tortuous due to the synergistic effect of nanoparticles. Compared with PE, EB of MMT/SiO2/PE is increased by 9.95%, the length entering the retardation stage of electrical trees decreases by 240 μm, and their morphology changes from branch to cluster like. Finally, microscopic and macroscopic results reveal that the combination of layered MMT and spherical SiO2 can effectively suppress the electrical tree growth in PE. These findings underscore the potential of utilizing nanostructured fillers to mitigate the development and expansion of electrical trees in polyethylene insulations, thereby enhancing the overall performance and reliability of power equipment.
Paper‐Based Device for Phenolic Content Determination in Tea Extracts
Authors: Silver Rachma Athaya , Noviana Eka , Ash Shiddiq Muhammad Al‐Fatih , Wardani Nur Kumala , Windarsih Anjar , Indrasyah Fauzian Sekar , Fakhrudin Nanang , Indrianingsih Anastasia Wheni , Henry Charles S. 
Published: December 2024

ABSTRACTIntroductionPhenolic compounds garner interest in developing medicines, nutraceuticals, and cosmeceuticals based on natural products. The quantity of phenolic compounds in a sample is commonly determined via spectrophotometry; however, this instrumented technique is relatively laborious and time consuming and requires a large amount of reagents.ObjectiveThis work aimed to develop a simple, point‐of‐need colorimetric sensor to rapidly determine total phenolic content (TPC) in tea extracts.MethodologyWe developed a radial paper‐based analytical device (PAD) for TPC determination based on the established colorimetric reaction between the Folin–Ciocâlteu reagent and phenols. The PAD was designed to enable quantitative (with image capturing device and color processing software) and semiquantitative (using a color palette reference card) determinations. Analytical performance and stability of the PAD were evaluated based on the color responses.ResultsThe PAD was successfully applied for the determination of phenolics in tea extracts obtained using several polar protic solvents, including water, methanol, and ethanol, with satisfactory accuracy (recovery of 95.5%–104%, 110%–116%, and 104%–110%, respectively) and precision (RSD < 9%). The obtained TPC values also agreed with those from visible spectrophotometry. Semiquantitative determination using the color reference card with three categories of TPC level (i.e., 0–100, 100–500, and 500–1000 mg gallic acid equivalent/L) provided > 95% accuracy. The devices were the most stable when stored at 4°C in a light‐protected, vacuum‐sealed container. The proposed PAD is promising for simple, rapid (~10–20 min), and accurate estimation of TPC in plant extracts.
The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers
Authors: Tian Xiaofan , Esmaeili Habib , Minich David , Seitz Friedeborg , Roessner Philipp M. , Wind Sven , Grempler Rolf , Gan Guanfa , Chan Tom S. , Mahmoudi Mazyar , Sadrolhefazi Behbood , Müller Fabian 
Published: December 2024

AbstractIntroductionZongertinib (BI 1810631) is a potent, selective, and epidermal growth factor receptor (EGFR) wild‐type sparing human epidermal growth factor receptor 2 (HER2) inhibitor. Based on in vitro data, the oxidative hepatic metabolism of zongertinib is principally driven by cytochrome P450 (CYP) 3A4/5. Therefore, zongertinib may be affected by strong CYP3A inducers, like carbamazepine.ObjectiveThis study aimed to investigate the effect of multiple oral doses of carbamazepine on the pharmacokinetics of a single oral dose of zongertinib in healthy male subjects.MethodsThis open‐label, two‐period, fixed‐sequence clinical drug–drug interaction study examined the pharmacokinetics of a single 60‐mg oral dose of zongertinib in the absence or presence of multiple oral doses of carbamazepine. The extent of drug–drug interaction was estimated using the adjusted geometric mean ratios (and 90% confidence intervals [CIs]) for the test treatment (zongertinib in the presence of carbamazepine) versus the reference treatment (zongertinib alone) for areas under the plasma concentration–time curve from time 0 to infinity and to the last quantifiable time point (AUC0–∞, AUC0–tz) and maximum measured plasma concentration (Cmax).ResultsSixteen subjects (all Caucasian males) received zongertinib alone in Study Period 1, and 15 of them received both zongertinib and carbamazepine in Study Period 2. Upon co‐administration with carbamazepine in Study Period 2, AUC0–∞ and AUC0–tz of zongertinib were both reduced to 36.5% (90% CI: 32.0%–41.6% for AUC0–∞ and 31.9%–41.7% for AUC0–tz). The Cmax of zongertinib was reduced to 56.4% (90% CI: 45.1%–70.6%).ConclusionZongertinib exposure was reduced by 63.5% when coadministered with the strong CYP3A inducer, carbamazepine.
Sensitivity determination and resistance mechanism of Sclerotium rolfsii to difenoconazole
Authors: Jiang Chaofan , Zhou Lin , Wang Mengke , Shen Sirui , Cheng Weifeng , Zhao Qingchen , Cui Kaidi , He Leiming 
Published: December 2024

AbstractBACKGROUNDPeanut stem rot, caused by Sclerotium rolfsii, has become increasingly prevalent in China, leading to significant yield losses in peanut production. To effectively manage peanut stem rot, we assessed the potential application of difenoconazole against peanut stem rot.RESULTSDifenoconazole has a good inhibitory effect on the mycelial growth of S. rolfsii, with half maximal effective concentration (EC50) values ranging from 0.10 to 1.58 μg/mL and an average of 0.33 ± 0.02 μg/mL. Nonetheless, a small percentage of wild‐type isolates exhibiting low resistance to difenoconazole were identified in the field. The primary reason for S. rolfsii resistance to difenoconazole was found to be attributed to the overexpression of CYP51. In addition, a small number of resistant isolates also exhibited multidrug resistance through the overexpression of efflux pump genes atrB and atrD. Pot experiments revealed that difenoconazole demonstrated superior protective efficacy against peanut stem rot, with mist spray treatment exhibiting better control efficacy compared to root drench treatment. Specifically, at a concentration of 100 μg/mL, the protective efficacy of difenoconazole mist spray against peanut stem rot reached 65.24%, which was statistically similar to that of tebuconazole. Furthermore, no significant correlation was observed between sensitivity to difenoconazole and mefentrifluconazole, benzovindiflupyr, boscalid, thifluzamide, carboxin, or picoxystrobin.CONCLUSIONTo delay the emergence of resistant populations, we recommend early‐stage application of difenoconazole via spraying for peanut stem rot management, alongside the judicious use of fungicides with no cross‐resistance like thifluzamide and boscalid for optimal control. © 2024 Society of Chemical Industry.
Circuit Emulating Neural Response Based on Ga2O3 Photomemristor
Authors: Sparvoli Marina , Chubaci José F. D. , Jorge Fábio O. , Fidelis Daniel G. , Goveia Gilson S. , Silva Tiago F. , Rodrigues Cléber L. , da Silva Antônio Ferreira , Mansano Ronaldo D. , Freitas Jaime A. 
Published: December 2024

Gallium oxide (Ga2O3), a transparent semiconductor material with wide bandgap between 4.5 and 4.9 eV, has attracted increasing interest lately due to multifunctionality. In this work, Ga2O3 films are deposited by ion‐beam‐assisted deposition method on p‐type silicon at ≈800 °C. Films deposited at lower temperatures predominantly have β‐phase structure, while those deposited at higher temperatures have dominant ε‐phase structure. Memristors testing devices are fabricated by depositing aluminum contacts over the Ga2O3 surface and the back surface of the substrate. In the Rutherford backscattering structural analysis, it is indicated that there is aluminum diffusion from the top contact into the film. The current–voltage measurement of the isolated device provides key information for understanding the memristor operation, revealing its bipolar characteristic and responsiveness to visible‐light soaking. The resistive switching behavior involving filament formation due to oxygen vacancies is discussed; however, since there is a light response, the most plausible explanation for the resistive switching is the trapping/detrapping mechanism. In the proposed neuromorphic circuit measurement, it is aimed to use a circuit that emulates a neuronal membrane and study the behavior of memristors response to light stimulus. This approach proves to be an excellent tool for observing action potentials, which mimic human vision.
Safety, tolerability, and efficacy of an in‐class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension
Authors: Morgan Cara , Idris Nikmah , Elterefi Kathy , Di Ienno Luca , Constantine Andrew , Quyam Sadia , Bini Roberta , Moledina Shahin 
Published: December 2024

AbstractThe aim of this single‐centre retrospective observational study was to evaluate the safety, tolerability, and efficacy of an in‐class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension. Children aged over 5 years who were established on sildenafil plus bosentan were offered to undergo a therapy switch from May 2014 to May 2021 and, if remaining in the service, followed up to May 2024. Children with Eisenmenger syndrome, open intra or extra‐cardiac shunt, or with pulmonary hypertension‐associated lung disease were excluded. As part of a structured clinical program children were assessed via walk test, echocardiography, cardiac magnetic resonance imaging (CMRI), cardiopulmonary exercise testing, and serum biomarkers. Fifty‐two children were included, 33 in the switch group and 19 in the control group. Clinical characteristics at diagnosis and baseline assessments did not differ between groups. All children tolerated the medication switch. Over a median 13.0 [12.0,13.7] week follow‐up in the switch group there was a significant improvement in World Health Organization functional class (WHO FC, p < 0.001); reduction in estimated right ventricular systolic pressure by echocardiography of 7 mmHg (p = 0.03) and a 2% increase (p = 0.03) in right ventricular ejection fraction on CMRI. There was a sustained improvement in WHO FC (p < 0.01) in the switch group at medium‐term follow‐up of 40.9 [35.2,49.3] weeks. Long‐term outcome of transplant‐ or Potts shunt‐free survival was comparable between the two groups.
Electronic and Magnetic Properties of Small Nickel Clusters Nin (n ≤ 15): First Principle Study
Authors: Chibani M. , Benamara S. , Zitoune H. , Lasmi M. , Benchalal L. , Lamiri L. , Samah M. 
Published: December 2024

ABSTRACTTheoretical study on the structure and electronic properties of small Nin (n ≤ 15) clusters has been carried out in the framework of density functional theory. The equilibrium geometries, the bond length, average binding energy, and magnetic moment per atom of these clusters were calculated in detail. The clusters constitute an intermediate state of matter between the isolated atoms and the massive condensed phase, and they do not mimic the bulk structure and shows significant geometrical changes with size. The binding energy per atom increases monotonically with size, and the magnetic moment oscillates with the size. The more stable structures are closed structures with inter atomic distances between 2.13 and 2.76 Å. The Ni2, Ni7, Ni9, Ni12, and Ni14 clusters are more stable than their neighboring clusters, and the most favorable channel for nickel clusters is the Ni14 cluster.
Scenario‐Based Distributed Robust Optimization for Optimal Virtual Power Plant Scheduling Under Uncertainty
Authors: Hu Jianqiang , Ding Yining , Cen Wanyi , Cao Jinde 
Published: December 2024

ABSTRACTDistributed robust optimization algorithms focus on developing decision‐making strategies that can operate effectively under uncertain conditions. This paper examines a scenario‐based distributed robust optimization algorithm for optimal scheduling of virtual power plants (VPPs). The proposed algorithm follows three key steps: scenario sampling, scenario reduction, and distributed optimization using the Alternating Direction Multiplier Method (ADMM). This approach balances robustness with computational complexity and ensures convergence, offering a practical solution for multi‐agent optimization. By employing an uncertainty set to represent the variabilities of wind and photovoltaic power generation, which leads to the establishment of a distributed robust optimization model for optimal virtual power plant scheduling. Experimental simulations validate the algorithm's feasibility and efficacy in economically optimal scheduling, offering methodological support for enhancing both robustness and economic efficiency in VPPs' operations.
Sustaining Linguistic Heritage Through Black‐Centric Texts
Authors: McMurtry Teaira 
Published: December 2024

AbstractAmerica's strength lies in its inherent diversity‐‐an enduring truth that makes the Eurocentric nature of our educational curricula troubling. Despite this foundational reality, curricular materials remain predominantly Eurocentric, often excluding authentic representation and inclusion of Black/African American experiences in children's and young adult literature. This issue is exacerbated by a politically charged environment where efforts to prioritize diversity, equity, and inclusion in education have been criminalized, particularly in southern states. Prioritizing cultural and linguistic diversity in U.S. classrooms is essential for nurturing and sustaining young learners' literate lives. This article aims to disrupt these inequities by analyzing the integration of culturally authentic texts, rooted in the lived experiences, perspectives, and traditions of Black/African American communities, to counter stereotypes and celebrate linguistic dexterity. Guided by culturally and linguistically relevant theories, the study presents a critical content analysis of three Black‐centric children's and pre‐adolescent books. These texts exemplify Black Livingness, showcasing joy, playfulness, and imagination in contemporary Black life while opposing anti‐Blackness. The findings highlight the importance of incorporating these texts in educational curricula to provide authentic representations of Black experiences, nurture students' cultural identities, and foster critical literacy. The article offers pedagogical recommendations for educators to meaningfully select and center Black‐centric texts, enhancing culturally relevant and rigorous literacy learning experiences. By disrupting harmful anti‐Black practices in curricula, educators can create learning environments that affirm and amplify Black linguistic capital, supporting the academic success and well‐being of Black students. Through this approach, the study aims to empower educators as transformative intellectuals and agents of change in promoting Black linguistic justice.
Bioinspired Synthesis of Transition Metal‐Enhanced Co₃O₄ Using Mangifera indica Leaves for Photocatalytic and Energy Storage Applications
Authors: Pradhan Debapriya , Biswal Susanta Kumar , Nayak Nibedita , Singhal Rahul , Beriha Swaraj kumar , Pattanaik Rasmirekha , Dash Suresh Kumar 
Published: December 2024

AbstractThe topic of wastewater remediation has been extensively discussed in recent years, and one of the main pollutants has been dyes. One of the promising techniques for dye degradation is photocatalysis. A novel transition metal Fe with different percentage (15%, 20%, 25%) doped Co3O4 was prepared employing a novel green process using Mangifera Indica leaf extract.The structural, morphological, optical, and electrical properties of doped catalyst was studied by XRD, FTIR, FE‐SEM, HR‐TEM, PL, CV, EIS, TGA, XPS, UV‐DRS, and BET analysis.By doping the Fe metal on the surface of Co3O4 resulting increase in surface area with improving charge carriers separation and lower the band gap energy. The photocatalytic activity was studied by degrading BG dye under solar light.25% Fe doped cobalt oxide having band gap energy 2.1 eV showed maximum degradation efficiency of 96% at pH 8 on 30 ppm dye concentration with 30 mg catalyst under 90min.The radical trapping experiment showed the vital role of hydroxyl and superoxide radical in degradation mechanism. By doping Fe atoms the efficiency of the host is increased which will be the most promising candidate for the photocatalytic dye degradation applications. The material presents a strong possibility for use in super capacitor applications due to its increased current density and lower on set potential.
Regulation of Metal‐Support Interaction in Single‐Atom Catalysis
Authors: He Lanxin , Guan Chen , Bulushev Dmitri A. , Xiang Quanjun 
Published: December 2024

AbstractIn recent years, single‐atom catalysts (SACs) with separated active centers and high atom utilization have grown significantly as a significant area of catalytic research. In catalytic applications, SACs of various kinds have demonstrated exceptional performance, so the study of the catalytic mechanism of SACs provides a clearer direction for the preparation of catalysts with high performance. Strong linkages between the single atoms and the support are necessary to overcome the tendency of single atoms to aggregate into clusters, which is called metal‐support interaction (MSI). MSI affects not only the stability of individual atoms, but also the nature of the binding site and applicable reactions. Therefore, investigating the connection between MSI and the catalytic mechanism is crucial. This work describes the latest developments in the means of MSI and activity modulation in single‐atom catalysis. First, the synthesis strategies of SACs are presented, including ALD, co‐deposition, impregnation, and so on. Second, the catalytic mechanisms realized by using MSI in the loading of SACs with different types of supports are highlighted. Third, the strategies for the modulation of single‐atom catalytic activity are discussed, including heterojunction strategy, ligand environment strategy, and dual‐single‐atom strategy. Finally, possible directions for future development in single‐atom catalysis are suggested.
Circulating Tumor Cells Culture: Methods, Challenges, and Clinical Applications
Authors: Zhou Zhengdong , Cai Songhua , Zhou Xiaoyu , Zhao Wei , Sun Jiayu , Zhou Zhihang , Yang Zihan , Li Wenxiu , Wang Zhe , Zou Heng , Fu Huayang , Wang Xicheng , Khoo Bee Luan , Yang Mengsu 
Published: December 2024

AbstractCirculating tumor cells (CTCs) play a pivotal role in cancer metastasis and hold considerable potential for clinical diagnosis, therapeutic monitoring, and prognostic evaluation. Nevertheless, the limited quantity of CTCs in liquid biopsy samples poses challenges for comprehensive downstream analysis. In vitro culture of CTCs can effectively address the issue of insufficient CTC numbers. Furthermore, research based on CTC cell lines serves as a valuable complement to traditional cancer cell line‐based research. While numerous reports exist on CTC in vitro culture and even the establishment of CTC cell lines, the methods used vary, leading to disparate culture outcomes. This review presents the developmental history and current status of CTC in vitro culture research. Additionally, the culture strategies applied in different methods and analyzed the impact of various steps on culture outcomes are compared. Overall, the review indicates that while the short‐term culture of CTCs is relatively straightforward, long‐term culture success has been achieved for various specific cancer types but still faces challenges. Further optimization of efficient and widely applicable culture strategies is needed. Additionally, ongoing applications of CTC in vitro culture are summarized, highlighting the potential of expanded CTCs for drug susceptibility testing and as therapeutic tools in personalized treatment.
Towards Transformative Supply Chain Research and Practice: A Critical Systems Perspective
Authors: Gregory Amanda , Atkins Jonathan , Dwivedi Ashish 
Published: December 2024

ABSTRACTThe argument that the supply chain discipline needed to make an epistemological break with functionalism in favour of a systems approach was made by Mears‐Young and Jackson (1997) but it has largely been overlooked. This paper seeks to address this oversight by demonstrating what a systems (multiparadigm, multimethodological) approach involves and means for supply chain theory and practice: the adoption of a broad range of paradigmatic perspectives, the juxtaposition and interplay of different perspectives and the creation of opportunities for understanding and action that offer the potential for transformational insight and change. Such a systems approach is demonstrated through the employment of three contrasting perspectives (objective‐positivist, subjective‐interpretivist and radical‐critical) to the case study of the supply chain for personal protective equipment (PPE) in the United Kingdom during the first year of the Covid pandemic. This case study is complex and multifaceted and demonstrates well the urgent practical need for a systems approach to supply chain theory and practice as each supply chain perspective offers only partial insight and understanding. In summary, this paper seeks to advance supply chain theory and practice by articulating what a systems approach to it involves.