bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast
Authors: Perez Garcia Georgina , De Gasperi Rita , Gama Sosa Miguel A. , Perez Gissel M. , Otero-Pagan Alena , Pryor Dylan , Abutarboush Rania , Kawoos Usmah , Hof Patrick R. , Dickstein Dara L. , Cook David G. , Gandy Sam , Ahlers Stephen T. , Elder Gregory A. 
Published: March 2021

AbstractMilitary veterans who experience blast-related traumatic brain injuries often suffer from chronic cognitive and neurobehavioral syndromes. Reports of abnormal tau processing following blast injury have raised concerns that some cases may have a neurodegenerative basis. Rats exposed to repetitive low-level blast exhibit chronic neurobehavioral traits and accumulate tau phosphorylated at threonine 181 (Thr181). Using data previously reported in separate studies we tested the hypothesis that region-specific patterns of Thr181 phosphorylation correlate with behavioral measures also previously determined and reported in the same animals. Elevated p-tau Thr181 in anterior neocortical regions and right hippocampus correlated with anxiety as well as fear learning and novel object localization. There were no correlations with levels in amygdala or posterior neocortical regions. Particularly striking were asymmetrical effects on the right and left hippocampus. No systematic variation in head orientation toward the blast wave seems to explain the laterality. Levels did not correlate with behavioral measures of hyperarousal. Results were specific to Thr181 in that no correlations were observed for three other phospho-acceptor sites (threonine 231, serine 396, and serine 404). No consistent correlations were linked with total tau. These correlations are significant in suggesting that p-tau accumulation in anterior neocortical regions and the hippocampus may lead to disinhibited amygdala function without p-tau elevation in the amygdala itself. They also suggest an association linking blast injury with tauopathy, which has implications for understanding the relationship of chronic blast-related neurobehavioral syndromes in humans to neurodegenerative diseases.
The aspiration test: an arthroscopic sign of lateral meniscus posterior horn instability
Authors: Jacquet Christophe , Magosch Amanda , Mouton Caroline , Seil Romain 
Published: March 2021

AbstractThe suspensory mechanism of the posterior horn of the lateral meniscus (PHLM) is an anatomically complex structure including the popliteomeniscal fascicles, the meniscotibial posterior root attachment and the meniscofemoral ligaments. Damage to one or several of these structures – either through knee trauma or congenital abnormalities—can result in an instability of the PHLM that may lead to lateral knee pain, locking sensations or lack of rotational control of the knee (e.g. after anterior cruciate ligament injuries). The diagnosis of PHLM instability is complex due to the lack of reliable clinical tests and imaging signs. Direct visual dynamic inspection via arthroscopy thus remains the gold standard. However, arthroscopic probing of the PHLM is not always reliable and the precise quantification of the amount of subluxation of the PHLM can be difficult. Therefore, the main objective of this report was to describe a quick and easy arthroscopic screening test called “the aspiration test” in order to help surgeons to detect PHLM instability. During the exploration of the lateral tibiofemoral compartment with the knee kept in the figure of 4 position, the arthroscope is placed in the antero-lateral portal and directed towards the lateral tibiofemoral compartment. The aspiration test is then performed by activating the aspiration of the 4-mm shaver when located in the intercondylar notch. In case of a PHLM instability, an excessive displacement of the PHLM is observed. After repair, a second aspiration test allows to verify that the PHLM has been stabilized.
The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2
Authors: Enogieru Osatohanmwen J. , Koleske Megan L. , Vora Bianca , Ngo Huy , Yee Sook Wah , Chatad Derrick , Sirota Marina , Giacomini Kathleen M. 
Published: March 2021

AbstractA rare cause of megaloblastic anemia (MA) is thiamine-responsive megaloblastic anemia (TRMA), a genetic disorder caused by mutations inSLC19A2(encoding THTR1), a thiamine transporter. The study objectives were to (1) functionally characterize selected TRMA-associated SLC19A2 variants and (2) determine whether current prescription drugs associated with drug-induced MA (DIMA) may act via inhibition of SLC19A2. Functional characterization of selected SLC19A2 variants was performed by confocal microscopy and isotopic uptake studies of [3H]-thiamine in HEK293 cells. Sixty-three drugs associated with DIMA were screened for SLC19A2 inhibition in isotopic uptake studies. Three previously uncharacterized SLC19A2 variants identified in TRMA patients exhibited disrupted localization to the plasma membrane along with near-complete loss-of-function. Ten of 63 drugs inhibited SLC19A2-mediated thiamine transport ≥ 50% at screening concentrations; however, with the exception of erythromycin, none was predicted to inhibit SLC19A2 at clinically relevant unbound plasma concentrations. Data from electronic health records revealed reduced levels of thiamine pyrophosphate (TPP) in patients prescribed erythromycin, consistent with inhibition of SLC19A2-mediated thiamine transport. Here, we confirmed the role of three SLC19A2 variants in TRMA pathology. Additionally, we report that inhibition of SLC19A2 is a potential, but uncommon mechanism for DIMA.
Mattilda Bernstein Sycamore
Authors: Gossett Che , Hayward Eva 
Published: March 2021

AbstractThe following is an interview with author and activist Mattilda Bernstein Sycamore conducted by Che Gossett and Eva Hayward. Sycamore discusses how she uses fiction to work through historical traumas, inviting readers to imagine the AIDS pandemic as not simply memory but as continuing crisis that necessitates desiring into the archive so that we might begin to understand AIDS. Trauma cannot be historically rendered—this is the catastrophe of this experience, past and present are affectively collapsed—so we must be creative in how we refuse to forget a pandemic that remains ongoing.
Uso Abusivo de Psicotrópicos e Fatores Associados com a Má Utilização na Atenção Primária à Saúde / Abuse of Psychotropics and Factors Associated with Misuse in Primary Health Care
Authors: Lima Tyssia Nogueira , Sousa Milena Nunes Alves de 
Published: March 2021

Na contemporaneidade, o uso excessivo de medicamentos parece ser um dos traços expressivos da civilização ocidental, na qual prevalece a persuasão de que o mal-estar, bem como o sofrimento de todo gênero, deve ser eliminado a qualquer custo. O uso de psicotrópicos é imprescindível no tratamento de alguns formatos de transtornos mentais ou distúrbios psiquiátricos, tais como: ansiedade, insônia, depressão, agitação, convulsão e a psicose. O objetivo desse trabalho, portanto, foi examinar os verdadeiros motivos da utilização de psicotrópicos e quais as características dos pacientes que o empregam. Este trabalho aborda-se sobre uma revisão integrativa da literatura e, para a elaboração do mesmo, algumas fases precisaram ser cursadas. Inicialmente foi feita a escolha do tema e posteriormente formada a questão de pesquisa; após esta etapa foram estabelecidos os critérios de inclusão e exclusão de artigos (seleção da amostra); identificação das informações a serem destacadas dos artigos selecionados; realização da análise dos resultados; findando com a discussão. O sexo feminino é mais perceptivo em relação à sintomatologia das doenças, por isso, procuram mais cedo por ajuda e apresentam menor resistência ao uso de medicamentos prescritos do que os homens. Pacientes sem uma ocupação profissional apresentam maior prevalência de transtornos mentais. A terapia alternativa não medicamentosa poderia ser abordada, para pacientes que proporcionaram transtornos de depressão, ansiedade e insônia. Os tratamentos medicamentosos para esses distúrbios envolvem fármacos que causam dependência química e efeitos colaterais, e isso leva, na maioria das vezes, as pessoas a se tratarem por longos períodos.
Effect of contacting pattern and various surfactants on phenol extraction efficiency using emulsion liquid membrane
Authors: Arun Varun , Segu Jalaludeen Samsnavith , Jayakumar Suryarajan , Swaminathan Samdavid 
Published: March 2021

Abstract
Emulsions prepared using different surfactants, including Span-80, BKC and CTAB, are studied for their stability and phenol remsoval efficiency. The effect of contacting pattern on ELM extraction efficiency is compared in Beaker – Stirrer apparatus and Bubble Flow Recirculation column. The emulsion prepared using Span-80 is relatively more stable than emulsions prepared using other surfactants. The emulsion stability during the extraction process is relatively higher in the Bubble Flow Recirculation column (15 min) than in the Beaker – Stirrer apparatus (10 min). At optimized conditions, the phenol removal efficiency of the emulsion prepared using Span-80 in Beaker – Stirrer apparatus is 96% and in Bubble Flow Recirculation column is 78%. Kinetic studies reveal that the extraction follows zeroth-order kinetics with an average phenol effective diffusivity of 0.0004 s at an initial phenol concentration ranging from 100–500 PPM.
Organizational behavior among academic medical school faculty
Authors: Hoegerl Carl 
Published: March 2021

AbstractThe study of organizational behavior in an academic medical school setting has many variables for consideration, including fragmentation, responsibilities, professionalism, burnout, and gender. In this Commentary, the author highlights some major factors affecting osteopathic physicians who practice in an academic setting, to bring to the attention of the medical community some of the inherent problems with modern academic medical education structure.
Significance of nucleic acid positive anal swab in COVID-19 patients
Authors: Li Xiaoli , Rong Lei , Zhang Peiyan , Xu Jian , Rong Yan 
Published: March 2021

Abstract

Aim
We compared the clinical characteristics of patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) positive and negative anal swabs during coronavirus disease 2019 (COVID-19) recovery and investigated the clinical significance and influence factors of anal swab detection.

Methods
This study retrospectively analyzed 23 moderate COVID-19 patients in the recovery phase. They were divided into anal swab positive group (n = 13) (negative for pharyngeal swabs but positive for anal swabs) and anal swab negative group (n = 10) (negative for pharyngeal and anal swabs). The epidemiology, clinical symptoms, time of pharyngeal swabs turning negative, and laboratory results were compared.

Results
The time of pharyngeal swabs turning negative in the anal swab positive group was 6 (5–8.5) days, significantly longer than that in the anal swab negative group (1 (1–4.25) days), P = 0.0002). The platelet count of the anal swab positive group was significantly lower than that of the anal swab negative group (198 (135–235) × 109/L vs 240.5 (227–264.75) × 109/L, P = 0.0248). No significant difference was observed between the two groups in other variables.

Conclusions
The time of pharyngeal swab turning negative in anal swab positive patients is longer than that in anal swab negative patients. The platelet count can be used as an indicator for viral infection evaluation. For patients with a longer time of pharyngeal swabs turning negative, the combined testing of the anal swab and platelet counts may help to avoid pharyngeal swab false negatives, premature discharge, and the possibility of fecal-oral transmission.
Impact of a Clinical Documentation Integrity Program on Severity of Illness of Expired Patients
Authors: Reardon Katelyn E. , Foley Corinna M. , Melvin Patrice , Agus Michael S. D. , Sanderson Amy L. 
Published: March 2021

BACKGROUND:
As payment models continue to move toward value-driven care, the quality of documentation has become more important than ever. Clinical Documentation Integrity (CDI) programs can aid in the documentation of diagnoses that are specific and consistent throughout the medical record, which leads to accurate code assignment, better understanding of patient complexity, and improved facility reimbursement.

METHODS:
An interrupted time series analysis was conducted by using a segmented regression model to estimate the impact of our hospital’s CDI program on perceived patient complexity using severity of illness stratification, observed to expected mortality ratio and case-mix index. Patients who died during the admission were chosen to limit our analysis to patients with the highest severity of illness.

RESULTS:
A total of 206 patients who had died while inpatient at our 400 bed children’s hospital were included. There was a 15.7% increase in patients who were final coded with the highest level of severity of illness after our CDI program launched compared with those patients admitted before program inception. The hospital case-mix index for inpatient cases increased 25% from 2011 to 2017. There was a 44% decrease in the observed to expected mortality ratio.

DISCUSSION:
A CDI program can have a significant impact, as evidenced by our ability to show complexity gains on some of the sickest patients by supporting documentation of precise, accurate diagnoses. In turn, this may allow for better understanding of the complexity of our patient population and support appropriate reimbursement and payer contract negotiations.
Developing a strategy for designing light in drug addiction centers
Authors: Sadoud Nesma , Zoltán Erzsébet Szeréna 
Published: March 2021

AbstractThe aim of this paper is to introduce the visual elements that may influence the lighting quality, and link them with the functioning of drug addiction institutes to understand the adequate design for each function and assure the well-being of the patient, therefore reduce their stress. The suggested strategy accords the qualitative and quantitative lighting design conditions to afford a complete reference for the forward study.
PELATIHAN KONSELOR SEBAYA UNTUK MENINGKATKAN SELF AWARENESS TERHADAP PERILAKU BERESIKO REMAJA
Authors: Yuliasari Hesty 
Published: March 2021

This study aims to determine the effectiveness of peer counselor training to increase self awareness of adolescent risk behavior. This research is an experimental study using one group pretest-posttest research design. Subjects in this study were 28 junior high school students in class VII and class VIII by using the sampling method purposive sampling because of the special characteristics of the subject. Measuring instruments used are adaptations from the Self Awareness Scale Arabsharhangi and Noroozi (2014) which refers to the theory of Self Awareness (Goleman, 1998). Data analysis using paired sample t-test. The results showed that peer counselor training increased self-awareness of risk behaviors in adolescents, t = - 8,482 and p = 0.011 (p 0.05). Increased self-awareness is found in aspects of emotional self awareness and self-assessment.
ANALISA KUAT TEKAN BATA MERAH PEJAL TERHADAP POSISI PEMBAKARAN DI DALAM TUNGKU KONVENSIONAL
Authors: Ahmad Irza , Budyany Herny 
Published: March 2021

Tujuan dari penelitian ini adalah untuk mengetahui perbedaan kekuatan kekuatan batu bata tanah liat terhadap posisi terbakar pada kotak api. Penelitian ini dilakukan di Laboratorium Struktur, Jurusan Teknik Sipil, Fakultas Teknik, Universitas Indonesia. Metode penelitian adalah eksperimen dengan tiga jenis pengobatan. Mereka adalah: kelompok pertama adalah posisi di atas kotak api, kelompok kedua adalah posisi di tengah-tengah kotak api, dan kelompok ketiga adalah bagian bawah kotak api. Jumlah semua batu bata yang diuji adalah 75 buah, masing-masing kelompok mendapat 20 batu bata tanah liat, untuk menguji kekuatan kekuatan dengan Crushing Test. Berdasarkan hasil penelitian, hasil penelitian menunjukkan bahwa rata-rata kekuatan kekuatan batako pada posisi atas kotak api adalah 7,48 Mpa, pada posisi tengah kotak api adalah 12,54 Mpa, dan dasar api kotak adalah 15,65 Mpa. Pengujian hipotesis dalam penelitian ini menggunakan AnalisisVarian (ANAVA) satu arah dengan hipotesis Ho: Î¼A = Î¼B = Î¼C dan H1: Î¼A â‰ Î¼B â‰ Î¼C. Dan penelitian lain menggunakan Uji Kesamaan Dua Rata-rata dengan hipotesis Ho: Î¼ = Î¼o dan H1: Î¼> Î¼o. Dari hipotesis pertama diterima Fhitung = 64,35> Ftabel = 4,998; Jadi hipotesis adalah perbedaan kekuatan kekuatan batu bata tanah liat yang signifikan terhadap pembakaran pos pada api kotak. Hipotesis kedua menerima thitung = 5,27> ttabel = 2,54; Sehingga hipotesis adalah kekuatan kekuatan batako tanah liat yang optimal lebih tinggi dari kekuatan kekuatan batako (SNI 15-2094-2000).
Propensity score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma
Authors: Chang Yi Lin , Cheng Ya-Fu , Chen Hui-Shan , Wu Siao-Chi , Hung Wei-Heng , Chen Heng-Chung , Huang Chang-Lun , Cheng Ching-Yuan , Wang Bing Yen 
Published: March 2021

Abstract
Background: The purpose of the current study is to compare definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma in survival.Methods: Records from 2008 to 2014 of 4931 patients with clinical T1-3/N0-3 esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or esophagectomy with adjuvant chemoradiotherapy were obtained from the Taiwan Cancer Registry. Univariable and multivariable analyses were performed and propensity score matching was used to minimize the bias. Overall survival was compared between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy, and also in the three different clinical stages.Results: Definitive chemoradiotherapy was performed on 4381 patients, and 550 patients received esophagectomy adjuvant chemoradiotherapy. Each group produced 456 patients for comparison after propensity score matching. The 1-year, 2-year, and 3-year overall survival rates for matched patients in with definitive chemoradiotherapy group were 57.18%, 31.92%, and 23.8%. The 1-year, 2-year, and 3-year overall survival rates for matched patients treated in the esophagectomy with adjuvant chemoradiotherapy group were 72.35%, 45.74%, and 34.04%(p<0.0001). In multivariable analysis, treatment modality was an independent prognostic factor. Esophagectomy with adjuvant chemoradiotherapy provided better survival outcome than definitive chemoradiotherapy for patients with clinical stage II/III disease. As for patients with clinical stage I disease, there was no significant survival difference between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy.Conclusions: Esophagectomy with adjuvant chemoradiotherapy provided better survival than definitive chemoradiotherapy in clinical II/III esophageal squamous cell carcinoma. However, more data are needed to conduct a convincing conclusion in clinical stage I patients.
Sustainment of Proactive Physical Therapy for Individuals with Early-Stage Parkinson’s Disease: A Quality Improvement Study over 4 years
Authors: MacDonald Jillian , Doyle Laura , Moore Jennifer L , Rafferty Miriam R 
Published: March 2021

Abstract
Background: Implementation science frameworks aided the development of a new, evidence-based clinical physical therapy program. The purpose of this report is to describe the process of sustaining a clinical program in practice for over four years. We present a framework for integrating tools for sustainability with the Knowledge-to-Action model in the context of a proactive physical therapy program (PAPT) for individuals with early stage Parkinson’s disease.Methods: Sustainability of implementation strategies was addressed using the Dynamic Sustainability Framework and sustainability assessment tools. Repeated retrospective medical record reviews and semi-structured interviews were used to evaluate the reach and adoption of the PAPT over four years. Characteristics of those who engaged with PAPT, implementation fidelity, and clinical effectiveness were assessed for Year 1 and Year 3. Sustainability was measured using RE-AIM, NHS Sustainability Model, and Clinical Sustainability Assessment Tool.Results: Reach increased from 28 to 110 total patients per year and spread occurred from one to three sites. PAPT user age, sex, Hoehn & Yahr rating, time since diagnosis and type of insurance were similar in Year 1 and Year 3 (p>0.05). The program sustained its effect to help participants increase or maintain self-reported exercise (Y1: 95%, Y3: 100%). However, upon evaluation PAPT users in Year 3 had longer time since symptom onset and worse UPDRS motor scores compared to the PAPT users in Year 1 (p<0.05). All sites sustained the core intervention components, with sustainability scores of 71/100 (± 9.9) on the NHS Sustainability Model and 6.1/7 (± 0.9) on the Clinical Sustainability Assessment Tool.Conclusions: Integrating multiple sustainability models and assessments supported continued effectiveness, spread, and sustainment of PAPT for four years. Effective planning, anticipating common healthcare changes, and addressing sustainability determinants early in program implementation were essential aspects of long-term success.
Greater preferences for death in hospital and mechanical ventilation at the end of life among non-whites recently diagnosed with cancer
Authors: Boyce David , Liao Kaiping , Miller Christopher , Peterson Susan K. , Elting Linda , Guadagnolo B. Ashleigh 
Published: March 2021

Abstract
Purpose: Minority cancer patients receive more aggressive care near death. This may indicate low quality end-of-life (EOL) care if discordant with patient preferences. We investigated preferred potential place of death and preferences regarding use of mechanical ventilation in a cohort of Texas cancer patients.Methods: A population-based convenience sample of recently diagnosed cancer patients from the Texas Cancer Registry was surveyed using a multi-scale inventory between March 2018 and June 2020. Item responses to questions about preferences regarding location of death and mechanical ventilation were the outcome measures of this investigation. Inverse probability weighting analysis was used to construct multivariable logistic regression examining the associations of covariates. Results: Of 1460 respondents, a majority (82%) preferred to die at home compared to 8% who preferred dying at the hospital. In total 25% of respondents expressed a preference for undergoing mechanical ventilation at the EOL. Adjusted analysis showed increased preference among Black (OR=1.81; 95% CI: 1.19-2.73) and other non-white, non-Hispanic race individuals (OR=3.53; 95% CI: 1.99-6.27) for dying at a hospital. Males, married individuals, those of higher education and poor self-reported health showed significantly higher preference for dying at home. Minority respondents of all non-white races were more likely to prefer mechanical ventilation at the EOL as were individuals who lived with another person at home. Conclusion: Minority cancer patients were more likely to express preferences coinciding with aggressive EOL care including dying at the hospital and utilizing mechanical ventilation. These findings were independent of other sociodemographic characteristics, including decisional self-efficacy.