bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnosis of early pneumoconiosis in dust-exposed workers: comparison of chest radiography and computed tomography
Authors: Hayashi Hideyuki , Ashizawa Kazuto , Takahashi Masashi , Kato Katsuya , Arakawa Hiroaki , Kishimoto Takumi , Otsuka Yoshinori , Noma Satoshi , Honda Sumihisa 
Published: June 2021

Background Chest radiography (CR) is employed as the evaluation of pneumoconiosis; however, we sometimes encounter cases in which computed tomography (CT) is more effective in detecting subtle pathological changes or cases in which CR yields false-positive results. Purpose To compare CR to CT in the diagnosis of early-stage pneumoconiosis. Material and Methods CR and CT were performed for 132 workers with an occupational history of mining. We excluded 23 cases of arc-welder’s lung. Five readers who were experienced chest radiologists or pulmonologists independently graded the pulmonary small opacities on CR of the remaining 109 cases. We then excluded 37 cases in which the CT data were not sufficient for grading. CT images of the remaining 72 cases were graded by the five readers. We also assessed the degree of pulmonary emphysema in those cases. Results The grade of profusion on CR (CR score) of all five readers was identical in only 5 of 109 cases (4.6%). The CR score coincided with that on CT in 40 of 72 cases (56%). The CT score was higher than that on CR in 13 cases (18%). On the other hand, the CT score was lower than that on CR in 19 cases (26%). The incidence of pulmonary emphysema was significantly higher in patients whose CR score was higher than their CT score. Conclusion CT is more sensitive than CR in the evaluation of early-stage pneumoconiosis. In cases with emphysema, the CR score tends to be higher in comparison to that on CT.
Influence of the study abroad bilingual experience on cognitive control among young adults
Authors: Xie Zhilong , Dong Yanping 
Published: June 2021

Aims and objectives/purpose/research questions: This study investigated whether the studying abroad bilingual experience among unevenly balanced Chinese–English bilinguals exerted influence on cognitive control. Design/methodology/approach: We compared cognitive control differences between a group of Chinese–English bilinguals (n = 30) studying abroad in the USA and a control bilingual group (n = 30) studying at home in mainland China by administering the Flanker task and the Wisconsin Card Sorting Test (WCST). The two groups were matched on demographic variables including age, socioeconomic status (SES), intelligence, etc. Data and analysis: A mixed ANOVA was applied to the Flanker task data, with the task condition as the within-subject variable and the participant group as the between-subject variable. Independent t-test analyses were used to compare performance differences between groups on the WCST. Findings/conclusions: The two groups performed similarly on the Flanker task, whereas the group studying abroad fared better on the WCST, indicating better mental set shifting. Originality: This is the first study to show that the experience of studying abroad brings about cognitive control advantage in mental set shifting. Significance/implications: The current research provides the first evidence that the experience of studying abroad is related to the enhancement of cognitive control, which has implications for both cognitive development and international education.
Birds and places: What the lexicon reveals about multilingualism
Authors: Döhler Christian 
Published: June 2021

Aims and objectives: The paper describes the current multilingual language ecology and explores two subdomains of the lexicon in order to infer information about the extent and nature of multilingualism in the past. Methodology: The paper employs quantitative and qualitative analysis of a sociolinguistic questionnaire in the first part. The second part includes a qualitative analysis of lexemes in the domains of bird names and plant names, and then compares them with old ethnographic sources as well as recent information on the surrounding languages. Data: The data of this study come from original fieldwork by the author in the village of Rouku and surrounding villages collected between 2010 and 2016. It is supplemented by material from colleagues working on related languages (Evans, Kashima and Siegel). Findings: The method suggests that the type of multilingualism that was practiced in the past is similar to today. Originality: The study is novel in providing a description of multilingualism from the Southern New Guinea area. Moreover, it advances a lexicographic and ethnographic approach in reconstructing the past state of a language ecology. Implications: The main conclusion is that in the absence of written historical sources – a problem that one is almost always facing in New Guinea – it is possible to extrapolate from the lexicon of Komnzo to a past state of the local language ecology. Limitations: The method does not allow for dating the point in time for which the inferences can be made.
Impact of screening on short-term mortality and morbidity following treatment for colorectal cancer
Authors: Wilhelmsen Michael , Njor Sisse Helle , Roikjær Ole , Rasmussen Morten , Gögenur Ismail 
Published: June 2021

Background and objective: The aim of this study was to describe short-term changes in morbidity and mortality associated with the implementation of screening for colorectal cancer in Denmark. Methods: Prospective cohort study with inclusion of all patients aged 50–75 years treated for colorectal cancer between 1 March 2014 and 31 December 2015 in Denmark. Adjusted hazard ratios were calculated for 30 and 90 days mortality using Cox Regression. We made two adjusted models—a “basic” adjusted for screening status, sex, age, smoking, alcohol consumption, and cancer type and an “advanced” that also included body mass index and American society of Anesthesiologists score in analyses. Relative risks were calculated for postoperative surgical and medical complications. Results: In total, 5348 patients were included. In the “basic model,” adjusted risk of 30 and 90 days total mortality was reduced in the screen-detected group (p < 0.01, HR = 0.43, CI = 0.24–0.76) and (p < 0.01, HR = 0.45, CI = 0.30–0.69). In the “advanced model,” only 90 days total mortality was significantly reduced in the screen-detected group (p = 0.01, HR 0.59, CI = 0.39–0.90). No significant changes were found with regard to surgical and medical complications, respectively, (p = 0.05 (CI = 0.76–1.00) and p = 0.47(CI = 0.74–1.15)). Conclusions: This nationwide study showed that screening for colorectal cancer was associated with a lower 90 days total mortality although no significant improvements were seen with regard to morbidity.
Impact of iliac arterial calcification on procedure success and long-term outcomes among patients undergoing endovascular intervention
Authors: Tasbulak Omer , Duran Mustafa , Aktemur Tugba , Guler Arda , Kahraman Serkan , Ulutas Ahmet Emir , Erturk Mehmet , Yalcin Ahmet Arif 
Published: June 2021

Objectives Vascular calcification is a well-known phenomenon and affects coronary and carotid arteries as well as other arterial beds. Presence of arterial calcification is associated with major adverse events in patients undergoing percutaneous coronary artery or carotid artery intervention. Even though there is a clear association between worse outcome and coronary-carotid calcification, there is no research that interrogated the relationship between iliac arterial calcification and clinical outcomes because of lack of data. Therefore, in this study, we aimed to investigate the impact of iliac arterial calcification on procedure success rates and long-term outcomes among patients undergoing endovascular intervention. Methods The records of 453 consecutive patients who underwent endovascular intervention due to symptomatic peripheral artery disease were analyzed. Patients were divided into two groups based on the presence or absence of heavy calcification of iliac arteries. For each group, technical aspects of procedures and subsequent clinical outcomes were analyzed. Results According to our study, the rate of restenosis following endovascular intervention at 6 and 12 months were similar between two groups. On the other hand, long-term restenosis was significantly higher in patients with heavy calcification of iliac arteries as compared to patients with low calcification on iliac arteries (32.2% vs. 12.8%, p <  0.05). Conclusions Our data showed that there was a strong association between heavy calcification of iliac arteries and long-term restenosis in patients undergoing endovascular intervention.
An Examination of the Glucose Management Indicator in Young Children with Type 1 Diabetes
Authors: Monzon Alexandra D. , Patton Susana R. , Clements Mark 
Published: June 2021

Background: Previous studies utilizing glucose data from continuous glucose monitors (CGM) to estimate the Glucose Management Indicator (GMI) have not included young children or determined appropriate GMI formulas for young children with type 1 diabetes (T1D). Methods: We extracted CGM data for 215 children with T1D (0-6 years) from a repository. We defined sampling periods ranging from the 3-27 days prior to an HbA1c measurement and compared a previously established GMI formula to a young child-specific GMI equation based on the sample’s CGM data. We examined associations between HbA1c, GMI values, and other CGM metrics for each sampling period. Results: The young child-specific GMI formula and the published GMI formula did not evidence significant differences when using 21-27 days of CGM data. The young child-specific GMI formula demonstrated higher correlations to laboratory HbA1c when using 18 or fewer days of CGM data. Overall, the GMI estimate and HbA1c values demonstrate a strong relationship in young children with T1D. Conclusions: Future research studies may consider utilizing the young child-specific GMI formula if the data collection period for CGM values is under 18 days. Further, researchers and clinicians may consider changing the default number of days of data used to calculate glycemic metrics in order to maximize validity of CGM-derived metrics.
Double matrix completion for circRNA-disease association prediction
Authors: Zuo Zong-Lan , Cao Rui-Fen , Wei Pi-Jing , Xia Jun-Feng , Zheng Chun-Hou 
Published: June 2021

Abstract
Background
Circular RNAs (circRNAs) are a class of single-stranded RNA molecules with a closed-loop structure. A growing body of research has shown that circRNAs are closely related to the development of diseases. Because biological experiments to verify circRNA-disease associations are time-consuming and wasteful of resources, it is necessary to propose a reliable computational method to predict the potential candidate circRNA-disease associations for biological experiments to make them more efficient.

Results
In this paper, we propose a double matrix completion method (DMCCDA) for predicting potential circRNA-disease associations. First, we constructed a similarity matrix of circRNA and disease according to circRNA sequence information and semantic disease information. We also built a Gauss interaction profile similarity matrix for circRNA and disease based on experimentally verified circRNA-disease associations. Then, the corresponding circRNA sequence similarity and semantic similarity of disease are used to update the association matrix from the perspective of circRNA and disease, respectively, by matrix multiplication. Finally, from the perspective of circRNA and disease, matrix completion is used to update the matrix block, which is formed by splicing the association matrix obtained in the previous step with the corresponding Gaussian similarity matrix. Compared with other approaches, the model of DMCCDA has a relatively good result in leave-one-out cross-validation and five-fold cross-validation. Additionally, the results of the case studies illustrate the effectiveness of the DMCCDA model.

Conclusion
The results show that our method works well for recommending the potential circRNAs for a disease for biological experiments.
Protein functional module identification method combining topological features and gene expression data
Authors: Zhao Zihao , Xu Wenjun , Chen Aiwen , Han Yueyue , Xia Shengrong , Xiang ChuLei , Wang Chao , Jiao Jun , Wang Hui , Yuan Xiaohui , Gu Lichuan 
Published: June 2021

Abstract
Background
The study of protein complexes and protein functional modules has become an important method to further understand the mechanism and organization of life activities. The clustering algorithms used to analyze the information contained in protein-protein interaction network are effective ways to explore the characteristics of protein functional modules.

Results
This paper conducts an intensive study on the problems of low recognition efficiency and noise in the overlapping structure of protein functional modules, based on topological characteristics of PPI network. Developing a protein function module recognition method ECTG based on Topological Features and Gene expression data for Protein Complex Identification.

Conclusions
The algorithm can effectively remove the noise data reflected by calculating the topological structure characteristic values in the PPI network through the similarity of gene expression patterns, and also properly use the information hidden in the gene expression data. The experimental results show that the ECTG algorithm can detect protein functional modules better.
Identification of long noncoding natural antisense transcripts (lncNATs) correlated with drought stress response in wild rice (Oryza nivara)
Authors: Xu Yong-Chao , Zhang Jie , Zhang Dong-Yan , Nan Ying-Hui , Ge Song , Guo Ya-Long 
Published: June 2021

Abstract
Background
Wild rice, including Oryza nivara and Oryza rufipogon, which are considered as the ancestors of Asian cultivated rice (Oryza sativa), possess high genetic diversity and serve as a crucial resource for breeding novel cultivars of cultivated rice. Although rice domestication related traits, such as seed shattering and plant architecture, have been intensively studied at the phenotypic and genomic levels, further investigation is needed to understand the molecular basis of phenotypic differences between cultivated and wild rice. Drought stress is one of the most severe abiotic stresses affecting rice growth and production. Adaptation to drought stress involves a cascade of genes and regulatory factors that form complex networks. O. nivara inhabits swampy areas with a seasonally dry climate, which is an ideal material to discover drought tolerance alleles. Long noncoding natural antisense transcripts (lncNATs), a class of long noncoding RNAs (lncRNAs), regulate the corresponding sense transcripts and play an important role in plant growth and development. However, the contribution of lncNATs to drought stress response in wild rice remains largely unknown.

Results
Here, we conducted strand-specific RNA sequencing (ssRNA-seq) analysis of Nipponbare (O. sativa) and two O. nivara accessions (BJ89 and BJ278) to determine the role of lncNATs in drought stress response in wild rice. A total of 1246 lncRNAs were identified, including 1091 coding–noncoding NAT pairs, of which 50 were expressed only in Nipponbare, and 77 were expressed only in BJ89 and/or BJ278. Of the 1091 coding–noncoding NAT pairs, 240 were differentially expressed between control and drought stress conditions. Among these 240 NAT pairs, 12 were detected only in Nipponbare, and 187 were detected uniquely in O. nivara. Furthermore, 10 of the 240 coding–noncoding NAT pairs were correlated with genes enriched in stress responsive GO terms; among these, nine pairs were uniquely found in O. nivara, and one pair was shared between O. nivara and Nipponbare.

Conclusion
We identified lncNATs associated with drought stress response in cultivated rice and O. nivara. These results will improve our understanding of the function of lncNATs in drought tolerance and accelerate rice breeding.
Bacterial and fungal bloodstream infections in pediatric liver and kidney transplant recipients
Authors: Møller Dina Leth , Sørensen Søren Schwartz , Wareham Neval Ete , Rezahosseini Omid , Knudsen Andreas Dehlbæk , Knudsen Jenny Dahl , Rasmussen Allan , Nielsen Susanne Dam 
Published: June 2021

Abstract
Background
Bacterial and fungal bloodstream infections (BSI) are common after pediatric liver and kidney transplantations and associated with morbidity and mortality. However, knowledge about incidence rates, pathogen composition, and resistance patterns is limited. We aimed to describe the pattern of bacterial and fungal BSI in a cohort of pediatric liver and kidney transplant recipients.

Methods
A prospective study of 85 pediatric liver and kidney transplant recipients transplanted from 2010 to 2017 with a total of 390 person-years of follow-up. Clinical characteristics and BSI were retrieved from national registries assuring nationwide follow-up for at least 1 year. BSI incidence rates and pathogen composition were investigated and stratified by the time post-transplantation and type of transplanted organ.

Results
A total of 29 BSI were observed within the first 5 years post-transplantation with 16 different pathogens. The overall incidence rate of first BSI was 1.91 per 100 recipients per month (95% CI, 1.1–3.1) in the first year post-transplantation. The most common pathogens were Enterococcus faecium, Candida albicans, Escherichia coli, and Klebsiella pneumoniae. The pathogen composition depended on the transplanted organ with a higher proportion of BSI with Enterobacterales in kidney transplant recipients than in liver transplant recipients (67% vs. 20%, p = 0.03), while multiple pathogens were detected in the liver transplant recipients.

Conclusions
BSI were common in pediatric liver and kidney transplant recipients and the pathogen composition differed between liver and kidney transplant recipients. Guidelines for empiric antibiotic therapy should consider the type of transplanted organ as well as the local resistance patterns.
Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis
Authors: Shibata Makoto , Hoshino Reona , Shimizu Chisato , Sato Masayuki , Furuta Natsumi , Ikeda Yoshio 
Published: June 2021

Abstract
Background
Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels. Neutropenia and cardiac events including sinus node dysfunction (SND) and atrioventricular block have been previously reported as adverse effects of LCM. To date, there have been no reports of severe agranulocytosis resulting in death associated with LCM. Additionally, there have been no reports of concomitant SND and agranulocytosis after LCM administration. Herein we report the first case of LCM-induced severe SND followed by agranulocytosis.

Case presentation
The patient with focal epilepsy was initiated on LCM 100 mg/day and the dose was increased to 200 mg/day on the 9th hospital day. Severe SND developed on the 10th hospital day and LCM was discontinued. Thereafter agranulocytosis appeared on the 11th hospital day, and the patient died from septic shock on the 15th hospital day.

Conclusions
This case illustrates the need for careful follow-up of the electrocardiogram and the complete blood cell counts when initiating LCM. Moreover, it should be noticed that various side effects may occur simultaneously in the early period of LCM use, even for a short time and at low dosages.
Effect of the standard herbal preparation, STW5, treatment on dysbiosis induced by dextran sodium sulfate in experimental colitis
Authors: Mohamed Sarah S. , Abdeltawab Nourtan F. , Wadie Walaa , Ahmed Lamiaa A. , Ammar Ramy M. , Rabini Sabine , Abdel-Aziz Heba , Khayyal Mohamed T. 
Published: June 2021

Abstract
Background
The standardized herbal preparation, STW 5, is effective clinically in functional gastrointestinal disorders and experimentally in ulcerative colitis (UC). The present study explores whether the beneficial effect of STW 5 involves influencing the intestinal microbiota.

Methods
UC was induced in Wistar rats by feeding them 5% dextran sodium sulfate (DSS) in drinking water for 7 days. Rats were treated concurrently with STW 5 and sacrificed 24 h after last drug administration. Fecal samples were used to determine changes in the abundance of selected microbial phyla and genera using real-time PCR.

Results
Induction of UC led to dysbiosis and changes in the gut microbiota. The changes included an increase in some genera of the Firmicutes, namely Enterococcus, and a decrease in others, namely Blautia, Clostridium, and Lactobacillus. DSS further induced a marked increase in the abundance of Bacteroidetes and Proteobacteria as well as in the relative abundance of Actinobacteria and its genus Bifidobacterium. Methanobrevibacter levels (phylum Euryarchaeota) were also increased. Microbial dysbiosis was associated with changes in various parameters of colonic inflammation. STW 5 effectively guarded against those changes and significantly affected the indices of edema and inflammation in the UC model. Changes in colon length, colon mass index, inflammatory and apoptotic markers, and histological changes induced by DSS were also prevented.

Conclusions
Dysbiosis plays a contributing role in the development of DSS-induced UC. Derangements in the microbial flora and associated inflammatory processes were largely prevented by STW 5, suggesting that this effect might contribute towards its beneficial usefulness in this condition.
The effect of peer modelling and discussing modelled feedback principles on medical students’ feedback skills: a quasi-experimental study
Authors: van Blankenstein Floris M. , O’Sullivan John F. , Saab Nadira , Steendijk Paul 
Published: June 2021

AbstractBackgroundTeaching is an important professional skill for physicians and providing feedback is an important part of teaching. Medical students can practice their feedback skills by giving each other peer feedback. Therefore, we developed a peer feedback training in which students observed a peer that modelled the use of good feedback principles. Students then elaborated on the modelled feedback principles through peer discussion. This combination of peer modelling and discussing the modelled feedback principles was expected to enhance emulation of the feedback principles compared to (1) only peer modelling and (2) discussing the feedback principles without previous modelling.MethodsIn a quasi-experimental study design, 141 medical students were assigned randomly to three training conditions: peer modelling plus discussion (MD), non-peer modelled example (NM) or peer modelling without discussion (M). Before and after the training, they commented on papers written by peers. These comments served as a pre- and a post-measure of peer feedback. The comments were coded into different functions and aspects of the peer feedback. Non-parametrical Kruskall-Wallis tests were used to check for pre- and post-measure between-group differences in the functions and aspects.ResultsBefore the training, there were no significant between-group differences in feedback functions and aspects. After the training, the MD-condition gave significantly more positive peer feedback than the NM-condition. However, no other functions or aspects were significantly different between the three conditions, mainly because the within-group interquartile ranges were large.ConclusionsThe large interquartile ranges suggest that students differed substantially in the effort placed into giving peer feedback. Therefore, additional incentives may be needed to motivate students to give good feedback. Teachers could emphasise the utility value of peer feedback as an important professional skill and the importance of academic altruism and professional accountability in the peer feedback process. Such incentives may convince more students to put more effort into giving peer feedback.