bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Effective Pulsed-Periodic Chemical HF(DF) Laser
Authors: Agroskin V. Ya. , Bravy B. G. , Vasiliev G. K. , Guriev V. I. , Kashtanov S. A. , Makarov E. F. , Sotnichenko S. A. , Chernyshev Yu. A. 
Published: November 2021

Abstract—
A working process is proposed for an HF(DF) laser, in which evacuation of the reactor is completely excluded. The workflow consists of the following stages: (1) displacement of the reaction products, which are formed after initiation of the working mixture, by an inert gas and (2) subsequent displacement of the inert gas by the working mixture. A design solution is proposed for the system of gas puffing into the reactor. Gas is supplied through an annular slot at one of the reactor ends, which makes it possible to minimize the consumption of inert gas used for displacing the reaction products after initiation of the working mixture. The amount of residual HF(DF) gas in the reactor is incapable of affecting the generation energy in the next cycle. It has been experimentally shown that the displacement technology does not lower the lasing energy in comparison with the pumping technology, but significantly reduces the duration of the HF(DF)-laser operating cycle by approximately two orders of magnitude).
Parental perspective on important health outcomes of extremely preterm infants
Authors: Jaworski Magdalena , Janvier Annie , Bourque Claude Julie , Mai-Vo Thuy-An , Pearce Rebecca , Synnes Anne R , Luu Thuy Mai 
Published: November 2021

Background and objectiveNeonatal outcome research and clinical follow-up principally focus on neurodevelopmental impairment (NDI) after extremely preterm birth, as defined by the scientific community, without parental input. This survey aimed to investigate parental perspectives about the health and development of their preterm children.MethodsParents of children aged 18 months to 7 years born <29 weeks’ gestational age presenting at a neonatal follow-up clinic over a 1-year period were asked to evaluate their children’s health and development. They were also asked the following question: ‘if you could improve two things about your child, what would they be?’ Responses were analysed using mixed methods. Logistic regressions were done to compare parental responses.Results248 parents of 213 children (mean gestational age 26.6±1.6 weeks, 20% with severe NDI) were recruited. Parents evaluated their children’s health at a median of 9/10. Parental priorities for health improvements were (1) development, mainly behaviour, emotional health and language/communication (55%); (2) respiratory heath and overall medical fragility (25%); and (3) feeding/growth issues (14%). Nineteen per cent explicitly mentioned ‘no improvements’. Parents were more likely to state ‘no improvements’ if child had no versus severe NDI OR 4.33 (95% CI 1.47 to 12.75)) or if parents had no versus at least a high school diploma (OR 4.01 (95% 1.99 to 8.10)).ConclusionsParents evaluate the health of their preterm children as being very good, with positive perspectives. Parental concerns outside the developmental sphere should also be addressed both in clinical follow-up and research.
Effects of school-based before-school physical activity programmes on children’s physical activity levels, health and learning-related outcomes: a systematic review
Authors: Woodforde James , Alsop Tahlia , Salmon Jo , Gomersall Sjaan , Stylianou Michalis 
Published: November 2021

ObjectiveTo review and evaluate the impact of school-based, before-school physical activity (PA) programmes on children’s PA levels, health and learning-related outcomes.DesignSystematic review.Data sourcesPubMed, PsycINFO, Scopus, Embase and ERIC were searched in January 2021.Eligibility criteria for selecting studies(1) Original research published in English, (2) sample included typically developing school-age children and/or adolescents, (3) examined school-based PA programmes delivered before school, (4) included a comparator and (5) reported associations with PA, physical health, learning-related and/or psychosocial outcomes. Studies examining before-school active transport or sport were excluded.ResultsThirteen articles representing 10 studies were included (published 2012–2020); seven conducted in primary schools. Programmes ranged between 3 weeks and 6 months, primarily operating daily and for 25–40 min. One study examined a programme informed by theory; six incorporated fidelity measures. Data synthesis, considering consistency of findings, showed indeterminate associations for the domains of physical health, learning-related and psychosocial outcomes. Among subdomains, synthesis showed positive associations with before-school and daily PA, cardiorespiratory and muscular fitness, readiness to learn and an inverse association with adiposity. Risk of bias was high/serious or insufficiently detailed across studies and outcome domains, except PA, which included moderate-risk studies.ConclusionThere is limited available evidence on school-based, before-school PA programmes, with some positive associations at domain and subdomain levels. Continued research is justified to understand the role of before-school programmes for facilitating PA. Future research should follow recommended practice for intervention design and process evaluation, and address under-represented contexts, including secondary schools.PROSPERO registration numberCRD42020181108.
Secondary erythrocytosis following drugs used in rifampicin/multidrug-resistant tuberculosis: a retrospective cohort study
Authors: Tesfamariam Sirak , Ghebrenegus Amon Solomon , Woldu Henok , Fisseha Ephrem , Belai Gebremeskel , Russom Mulugeta 
Published: November 2021

BackgroundMultidrug-resistant tuberculosis (MDR-TB) drugs have never been associated with erythrocytosis. In Eritrea, however, several cases of incident erythrocytosis had been observed in the MDR-TB hospital. This study was aimed at exploring the association between MDR-TB drugs and secondary erythrocytosis, characterising the cases, and identifying other possible risk factors.MethodsA retrospective cohort study was conducted in Merhano National Referral MDR-TB hospital. Data were extracted from physically available clinical cards and laboratory results collected longitudinally between 23 June 2011 and 17 January 2021. Initially, univariate descriptive statistics (frequency, mean (SD), median (IQR) and range) were used as appropriate. Then, χ2or Fisher χ2test, and bivariate and/or multivariate Cox proportional hazard model were used to identify the predictors of incident erythrocytosis. All statistical analyses were conducted using R, and a two-sided alpha 0.05 was used to determine the statistical significance.ResultsA total of 257 patients’ medical cards were screened, and 219 were eligible for further analysis. The median age of the patients was 38 years (range: 13–90 years) and 54.8% were males. During the follow-up time, 31 (14.2%) patients developed secondary erythrocytosis yielding an incidence rate of 7.8 cases per 1000 person-months. On average, the median time to onset of the event was found to be 5-months (range: 1–24 months). Males were more likely to develop the event than females (adjusted HR=7.13, 95% CI=1.66 to 30.53), and as body weight increases by 1 kg, the likelihood of developing secondary erythrocytosis was found to increase by 7% (adjusted HR=1.07, 95% CI=1.03 to 1.10). Moreover, all cases of secondary erythrocytosis were found to be possibly associated with the MDR-TB drugs.ConclusionThe authors hypothesised that the incident erythrocytosis is possibly be associated with MDR-TB drugs, and further studies are required to substantiate this finding.
Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet
Authors: Vervier Kevin , Moss Stephen , Kumar Nitin , Adoum Anne , Barne Meg , Browne Hilary , Kaser Arthur , Kiely Christopher J , Neville B Anne , Powell Nina , Raine Tim , Stares Mark D , Zhu Ana , De La Revilla Negro Juan , Lawley Trevor D , Parkes Miles 
Published: November 2021

ObjectiveReducing FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) can be clinically beneficial in IBS but the mechanism is incompletely understood. We aimed to detect microbial signatures that might predict response to the low FODMAP diet and assess whether microbiota compositional and functional shifts could provide insights into its mode of action.DesignWe used metagenomics to determine high-resolution taxonomic and functional profiles of the stool microbiota from IBS cases and household controls (n=56 pairs) on their usual diet. Clinical response and microbiota changes were studied in 41 pairs after 4 weeks on a low FODMAP diet.ResultsUnsupervised analysis of baseline IBS cases pre-diet identified two distinct microbiota profiles, which we refer to as IBSP (pathogenic-like) and IBSH (health-like) subtypes. IBSP microbiomes were enriched in Firmicutes and genes for amino acid and carbohydrate metabolism, but depleted in Bacteroidetes species. IBSH microbiomes were similar to controls. On the low FODMAP diet, IBSH and control microbiota were unaffected, but the IBSP signature shifted towards a health-associated microbiome with an increase in Bacteroidetes (p=0.009), a decrease in Firmicutes species (p=0.004) and normalisation of primary metabolic genes. The clinical response to the low FODMAP diet was greater in IBSP subjects compared with IBSH (p=0.02).Conclusion50% of IBS cases manifested a ‘pathogenic’ gut microbial signature. This shifted towards the healthy profile on the low FODMAP diet; and IBSP cases showed an enhanced clinical responsiveness to the dietary therapy. The effectiveness of FODMAP reduction in IBSP may result from the alterations in gut microbiota and metabolites produced. Microbiota signatures could be useful as biomarkers to guide IBS treatment; and investigating IBSP species and metabolic pathways might yield insights regarding IBS pathogenic mechanisms.
A low-carbon future for The North Sea Basin
Authors: Quirk David G. , Underhill John R. , Gluyas Jon G. , Howe Matthew J. , Wilson Hamish A. M. , Anderson Sean 
Published: November 2021

Abstract
Human emissions of greenhouse gases have caused a predictable rise of 1.2 °C in global temperatures. Over the last 70 years, the rise has occurred at a geologically unprecedented speed and scale. To avoid a worsening situation, most developed nations are turning to renewable sources of power to meet their climate commitments, including the UK, Norway, Denmark and The Netherlands. The North Sea basin offers many advantages in the transition from fossil fuels by virtue of its natural resources, physical setting, offshore infrastructure and skilled workforce. Nonetheless, the magnitude of the up-front costs and the scale required to achieve net zero emissions are rarely acknowledged. In addition, some of the technologies being planned are commercially immature. In particular, the current cost of the capture, transport and disposal of carbon dioxide is problematic as a large-scale solution to industrial emissions. Repurposing the North Sea to meet a low-carbon future will require substantial collaboration between governments and industrial sectors. There are nonetheless significant opportunities for companies prepared to switch from the traditional oil and gas business to renewable energy production and other sustainable activities.
Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon
Authors: Yang Yongjian , Osorio Daniel , Davidson Laurie A. , Han Huajun , Mullens Destiny A. , Jayaraman Arul , Safe Stephen , Ivanov Ivan , Cai James J. , Chapkin Robert S. 
Published: November 2021

Abstract

Despite recent progress recognizing the importance of aryl hydrocarbon receptor (Ahr)-dependent signaling in suppressing colon tumorigenesis, its role in regulating colonic crypt homeostasis remains unclear. To assess the effects of Ahr on intestinal epithelial cell heterogeneity and functional phenotypes, we utilized single-cell transcriptomics and advanced analytic strategies to generate a high-quality atlas for colonic intestinal crypts from wild-type and intestinal-specific Ahr knockout mice. Here we observed the promotive effects of Ahr deletion on Foxm1-regulated genes in crypt-associated canonical epithelial cell types and subtypes of goblet cells and deep crypt–secretory cells. We also show that intestinal Ahr deletion elevated single-cell entropy (a measure of differentiation potency or cell stemness) and RNA velocity length (a measure of the rate of cell differentiation) in noncycling and cycling Lgr5+ stem cells. In general, intercellular signaling cross-talk via soluble and membrane-bound factors was perturbed in Ahr-null colonocytes. Taken together, our single-cell RNA sequencing analyses provide new evidence of the molecular function of Ahr in modulating putative stem cell driver genes, cell potency lineage decisions, and cell–cell communication in vivo.

Prevention Relevance:
Our mouse single-cell RNA sequencing analyses provide new evidence of the molecular function of Ahr in modulating colonic stemness and cell–cell communication in vivo. From a cancer prevention perspective, Ahr should be considered a therapeutic target to recalibrate remodeling of the intestinal stem cell niche.
Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity
Authors: Joshi Abhishek , Schmidt Lukas E. , Burnap Sean A. , Lu Ruifang , Chan Melissa V. , Armstrong Paul C. , Baig Ferheen , Gutmann Clemens , Willeit Peter , Santer Peter , Barwari Temo , Theofilatos Konstantinos , Kiechl Stefan , Willeit Johann , Warner Timothy D. , Mathur Anthony , Mayr Manuel 
Published: November 2021

Objective:
Platelets are central to acute myocardial infarction (MI). How the platelet proteome is altered during MI is unknown. We sought to describe changes in the platelet proteome during MI and identify corresponding functional consequences.

Approach and Results:

Platelets from patients experiencing ST-segment–elevation MI (STEMI) before and 3 days after treatment (n=30) and matched patients with severe stable coronary artery disease before and 3 days after coronary artery bypass grafting (n=25) underwent quantitative proteomic analysis. Elevations in the proteins S100A8 and S100A9 were detected at the time of STEMI compared with stable coronary artery disease (S100A8: FC, 2.00; false discovery rate, 0.05; S100A9: FC, 2.28; false discovery rate, 0.005). During STEMI, only S100A8 mRNA and protein levels were correlated in platelets (
R
=0.46,
P
=0.012). To determine whether de novo protein synthesis occurs, activated platelets were incubated with 13C-labeled amino acids for 24 hours and analyzed by mass spectrometry. No incorporation was confidently detected. Platelet S100A8 and S100A9 was strongly correlated with neutrophil abundance at the time of STEMI. When isolated platelets and neutrophils were coincubated under quiescent and activated conditions, release of S100A8 from neutrophils resulted in uptake of S100A8 by platelets. Neutrophils released S100A8/A9 as free heterodimer, rather than in vesicles or extracellular traps. In the community-based Bruneck study (n=338), plasma S100A8/A9 was inversely associated with platelet reactivity—an effect abrogated by aspirin.

Conclusions:
Leukocyte-to-platelet protein transfer may occur in a thromboinflammatory environment such as STEMI. Plasma S100A8/A9 was negatively associated with platelet reactivity. These findings highlight neutrophils as potential modifiers for thrombotic therapies in coronary artery disease.
Diversion of Attention Leads to Conflict between Concurrently Attended Stimuli, Not Delayed Orienting to the Object of Interest
Authors: Hoffmeister Jennifer-Ashley , Smit Andrea N. , Livingstone Ashley C. , McDonald John J. 
Published: November 2021

AbstractThe control processes that guide attention to a visual-search target can result in the selection of an irrelevant object with similar features (a distractor). Once attention is captured by such a distractor, search for a subsequent target is momentarily impaired if the two stimuli appear at different locations. The textbook explanation for this impairment is based on the notion of an indivisible focus of attention that moves to the distractor, illuminates a nontarget that subsequently appears at that location, and then moves to the target once the nontarget is rejected. Here, we show that such delayed orienting to the target does not underlie the behavioral cost of distraction. Observers identified a color-defined target appearing within the second of two stimulus arrays. The first array contained irrelevant items, including one that shared the target's color. ERPs were examined to test two predictions stemming from the textbook serial-orienting hypothesis. Namely, when the target and distractor appear at different locations, (1) the target should elicit delayed selection activity relative to same-location trials, and (2) the nontarget search item appearing at the distractor location should elicit selection activity that precedes selection activity tied to the target. Here, the posterior contralateral N2 component was used to track selection of each of these search-array items and the previous distractor. The results supported neither prediction above, thereby disconfirming the serial-orienting hypothesis. Overall, the results show that the behavioral costs of distraction are caused by perceptual and postperceptual competition between concurrently attended target and nontarget stimuli.
Restoring (Old) Questions of Sovereignty under the Cover of Minority Protection?
Authors: Gruber Mirjam , Marcher Anja 
Published: November 2021

Abstract
Minority groups are often the subject of studies dealing with sovereignty and European integration. A now also common topic in political science is the rise of populist movements. Scholars study both of these issues extensively, but little research has been done on their nexus. Against this background, this article looks at the current sovereignty discourse in the minority area of South Tyrol. Even though three linguistic groups peacefully co-exist in the Italian province, various calls for dual citizenship have arisen. The possibility of acquiring an Austrian passport became a salient topic, especially since the övp/fpö government of Austria. Using the discourse-historical approach, the authors contextualize medial discourses with social-cultural context information. Results suggest that local media are disseminating a discourse regarding dual citizenship that largely differs from the opinion of the majority of the population, but corresponds to that of the populist actors who seem to fuel the issue.
‘Jáchymov’s Hell’: Trekking in the Memoryscape of Czechoslovakia’s Communist Forced Labour Camps
Authors: Holá Barbora , Bouwknegt Thijs 
Published: November 2021

Abstract
This article treks through the timeworn remnants of Czechoslovakia’s Communist forced and correctional labour uranium camps in the Ore Mountains in the northwest Bohemian region of Jáchymov. These camps held tens of thousands of detainees, largely political prisoners convicted in sham trials or individuals sent there for re-education. Conditions were deplorable. Throughout the 1950s, the young Czechoslovak Communist regime compelled detainees to hard, life threatening labour and subjected them to maltreatment and arbitrary violence. This article traces some of the visible, invisible or overgrown artefacts of the former camps, as well as public as private memories about what happened there. It reflects on the current memoryscape of these forgotten places of human suffering and describes the aesthetics of these aging sites of atrocity.
The Visualities and Aesthetics of Prosecuting Aged Defendants
Authors: Drumbl Mark , Fournet Caroline 
Published: November 2021

Abstract
The prosecution—whether domestic or international—of international crimes and atrocities may implicate extremely aged defendants. Much has been written about the legalisms that inhere (or not) in trying these barely alive individuals. Very little however has been written about the aesthetics the barely alive encrust into the architecture of courtrooms, the optics these defendants suffuse into the trial process, and the expressive value of punishing them. This is what we seek to do in this project.
W.E.B. Du Bois’s Constructivist Theory of Justice
Authors: Basevich Elvira 
Published: November 2021

Abstract
This essay presents the normative foundation of W.E.B. Du Bois’s constructivist theory of justice in three steps. First, I show that for Du Bois the public sphere in Anglo-European modern states consists of a dialectical interplay between reasonable persons and illiberal rogues. Second, under these nonideal circumstances, the democratic ideal of autonomy grounds reasonable persons’ deliberative openness, an attitude of public moral regard for others which is necessary to construct the terms of political rule. Though deliberative openness is the essential vehicle of construction, reasonable persons only have a pragmatic political obligation to forge ties of deliberative reciprocity with likeminded persons whom they trust will listen and not harm them. Finally, I present Du Bois’s defense of black suffragists’ support of the 19th Amendment to illustrate pragmatic political obligation in action. I sketch successful democratic engagement that reconstitutes a nonideal public sphere.
Fine-Scale Velocity Measurement on the Wirewalker Wave-Powered Profiler
Authors: Zheng Bofu , Lucas Andrew J. , Pinkel Robert , Le Boyer Arnaud 
Published: November 2021

Abstract
The Wirewalker (WW) ocean-wave-powered vertical profiling system allows the collection of high-resolution oceanographic data due to its rapid profiling, hydrodynamically quiet operation, and long endurance. We have assessed the potential for measuring fine-scale ocean velocities from the Wirewalker platform using commercially available acoustic velocimeters. Although the vertical profiling speed is relatively steady, platform motion affects the velocity measurements and requires correction. We present an algorithm to correct our velocity estimates using platform motion calculated from the inertial sensors—accelerometer, gyroscope, and magnetometer—on a Nortek Signature1000 acoustic Doppler current profiler (ADCP). This correction, carried out ping by ping, was effective in removing the vehicle motion from the measured velocities. The motion-corrected velocities contain contributions from surface wave orbital velocities, especially near the surface, and the background currents. To proceed, we use an averaging approach that leverages both the vertical platform profiling of the system and the ∼15–20 m vertical profiling range resolution of the down-looking ADCP to separate the surface wave orbital velocities and the background flow. The former can provide information on the wave conditions. From the latter, we are able to estimate fine-scale velocity and shear with spectral wavenumber rolloff at vertical scales around 3 m, a vertical resolution several times finer than that possible from modern shipboard or fixed ADCPs with similar profiling range, and similar to recent glider measurements. When combined with a continuous time series of buoy drift calculated from the onboard GPS, a highly resolved total velocity field is obtained, with a unique combination of space and time resolution.