bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoma of the Rectum: A Clinicopathological Evaluation of Patients in Tertiary Care Hospitals
Authors: Hossain Mohammad Arif , Bhuiyan Md Jahangir Kabir , Talukdar Tutul , Quader Feroze 
Published: March 2021

Background: Colorectal carcinoma is the fourth most commonly diagnosed cancer and the third leading cause of cancer deaths worldwide. The rectum is the most frequent site involved. The disease is no less common in our country in comparison to western world. The aim of this study was to determine the incidence and to review the clinicopathological aspects of carcinoma rectum in different ages in our country.
Methods: This is a prospective observational study which includes 50 cases of carcinoma rectum which were admitted under different surgical units of Dhaka Medical College Hospital and Bangabandhu Sheikh Mujib Medical University during the period of November 2007 to December 2008.
Results: The present study showed maximum incidence of carcinoma rectum in the age group 21-30 years. Next common age group was 31-40 years. Incidence declined after 60 years. Majority of victims were male giving a male to female ratio of 1.17:1. As regards the mode of clinical presentation, most patients presented with bleeding per rectum. Majority of patients in this study was moderately anaemic. Curative resection was possible in 54% cases, palliative resection in 38% and palliative end colostomy was done in 4% cases. Only 2% mortality was reported in this study. Histopathological grading showed that poorly differentiated adenocarcinoma of rectum was more common in younger age group.
Conclusion: Younger patients with carcinoma rectum have several distinct clinicopathological features. Since early diagnosis is essential to improve the cure rate for carcinoma rectum, all known procedure tools must be used to detect carcinoma of the rectum in an early stage, in addition to periodic selective investigations of high-risk group.
Journal of Surgical Sciences (2020) Vol. 24 (1) : 15-20
Radical Surgical Excision and Use of Axillary Flap for Intractable Axillary Hidradenitis Suppurativa
Authors: Momotaz Munny , Kalam Abul , Khondoker Md Sazzad , Sumi Sharmin Akter 
Published: March 2021

Background: Current treatments for hidradenitis suppurativa (HS) include prolonged courses of antibiotics, retinoids, immunosuppressants, and biologics. Severe cases that are resistant to prolonged medical treatment pose a therapeutic challenge. We propose radical excision and reconstruction with axillary flap as a treatment option for such cases.
Objectives: The purpose of the study was to see the outcome after radical surgical excision and coverage with axillary flap for intractable Hidradenitis suppurativa.
Methods: This prospective observational study was carried out from July, 2014 to June,2016. Patients admitted at the Plastic Surgery Department of Dhaka Medical College Hospital with intractable Hydradenitis suppurativa were included the study population.
Result:Among 20 cases, 12 cases were female and 8 cases were male. Maximum dimension of the soft tissue defect was 15x6.5 cm2 = (97.5 cm2). Maximum dimension of the flap was 17x7 cm2 = (119 cm2).Flap survived completely with minimum donor site morbidity. Result of reconstruction of 90% of the patients exhibited excellent outcome. In 10% patient’s outcome was considered good.
Conclusion:With a suitable flap coverage option, the management paradigm of intractable Hydradenitis Suppurativa should shift from prolonged medical treatment to allowdecisive radical excision, which will improve the quality of life for patients. Axilary flap is the flap of choice to cover the defect.
Journal of Surgical Sciences (2020) Vol. 24 (2) : 51-56
Comparison of Onlay versus Sublay Mesh Repair in Ventral Hernia : Our Experience in a Peripheral Hospital
Authors: Pervin Mst Shahnaj , Md Nuruzzaman Hasan Shahriar , Sultana Eliza , Ahmad Anis Uddin 
Published: March 2021

Background: Mesh repair is the standard procedure of choice for the ventral hernia repair. The common techniques for this surgery are onlay and sublay repair. But the superior technique between the two is yet to be established objectives.
Objectives: We conducted this study to compare the results of Onlay with Sublay mesh repair for the treatment of ventral hernia.
Methods: This comparative study was conducted at the department of Surgery, Shaheed Tajuddin Ahmad Medical College Hospital, Gazipur from April 2018 to April 2019. 20 patients withclinically diagnosed ventral hernia were randomized into two groups. The patients in group A had onlay mesh repair while those of group B hadsublay mesh repair. Comparison between the two methods were made in terms of operative time, technical ease, early post operative events specially drain & complication, hospital stay, recurrence.
Result: Twenty patients between 20 to 70 years of age among whom 6 are male and 14 are female with different types of ventral hernia including paraumbilical, umbilical, epigastric and incisional, except with defect more than 15 cm were studied. The sublay repair took significantly longer operative time (p = .023). Onlay repair group had more seroma formation, wound infection and recurrence, though not statistically significant. Patients who underwent sublay repair had early removal of drains (3.7 ± .823 days vs 6 ± .738 days) which was significant (p= .000). At the same time sublay repair group had significantly shorter hospital stay than the onlay group (4.5 ± 1.900 days vs 6 ± 1.354 days, p= .023).
Conclusion: Sublay repair seems to be a better alternative than onlay repair of Ventral hernia. Randomised controlled trial with larger case numbers is needed to validate the result.
Journal of Surgical Sciences (2020) Vol. 24 (2) : 61-65
Nipple Skin Sparing Mastectomy and Immediate Reconstruction with implant using Acellular Dermal Matrix (ADM)in a Patient with TP53 mutation - First Experience in Bangladesh
Authors: Ahmed SK Farid , Nafisa Ali , Priam Samanta Meharin , Ferdous Hasnatul , Rahman ASM Tanjilur , Khan Md Salim , Riad Mahedi Hassan 
Published: March 2021

A 28-year-old lady presented with 3.5 cm lump in her right breast and normal axilla. Histopathologically the lump revealed as invasive duct cell cancer (IDC), Grade II with ER negative, PR positive and HER2 equivocal. On genetic testing, BRCA1 & BRCA2were found negative but p53 was positive with pathogenic variant. She received neoadjuvant chemotherapy while waiting for genetic testing. As she had TP53 mutation and considered high risk for developing contralateral breast cancer, bilateral mastectomy and immediate reconstruction with implant using acellular dermal matrix was performed on 9th of March,2020 at our Breast Unit during 2nd live surgery & workshop on oncoplastic breast surgery, organized by Breast Care Unit and Research Centre, Department of Surgery, Anwer Khan Modern Medical college. This is the first reported case of a breast cancer patient with TP53 mutation who has undergone nipple skin sparing mastectomy with immediate implant/ADM reconstruction and creates a milestone in the history of modern breast cancer management in Bangladesh.
Journal of Surgical Sciences (2020) Vol. 24 (2) : 77-82
Peningkatan Pemahaman tentang Komitmen Melayani Karyawan Gereja-gereja Kristen Jawa (GKJ) Klasis Jakarta Bagian Timur
Authors: Sianipar Desi , Rini Wahyu A. , Jura Demsy 
Published: March 2021

Karyawan yang bekerja di gereja perlu mendapatkan pembinaan secara berkala, khususnya menyangkut komitmen mereka dalam melayani di lingkungan gereja. Dengan adanya pembinaan mengenai hal ini, semangat dan produktivitas mereka dapat ditingkatkan. Untuk itu, kegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk memberikan pengetahuan tentang komitmen melayani berdasarkan ajaran dalam Alkitab pada karyawan Kristen di lingkungan Gereja-gereja Kristen Jawa (GKJ) klasis Jakarta Bagian Timur. Metode yang digunakan adalah seminar dan kemudian dilanjutkan dengan tanya jawab dan diskusi. Hasil dari kegiatan ini adalah karyawan merasakan bahwa seminar ini sangat bermanfaat untuk meningkatkan pemahaman mereka mengenai makna komitmen melayani menurut iman Kristen, dan mereka termotivasi untuk melakukan pelayanan yang lebih baik lagi. Hal ini terlihat dari antusiasme mereka dalam sesi tanya jawab, diskusi, dan hasil angket yang mereka isi setelah selesai kegiatan pengabdian kepada masyarakat. Mereka juga mengusulkan supaya kegiatan pembinaan yang bertujuan meningkatkan komitmen mereka dalam melayani diadakan secara berkala oleh GKJ Klasis Jakarta Bagian Timur.

Kata Kunci: komitmen melayani
Abstract Employees who work in the church need to get regular guidance, especially regarding their commitment to serving in the church environment. With the guidance on this matter, their enthusiasm and productivity can be improved. For this reason, Community Service activities (PkM) aim to provide knowledge about the commitment to serve based on the teachings in the Bible to Christian employees in the Javanese Christian Church (GKJ) East Jakarta area. The method used is a seminar and then followed by question and answer and discussion. The results of this activity are that employees feel that this seminar is very useful to improve their understanding of the meaning of commitment to serve according to the Christian faith, and they are motivated to do better service. This can be seen from their enthusiasm in the question and answer session, discussion, and the results of the questionnaire they filled in after the community service activities were completed. They also proposed that coaching activities aimed at increasing their commitment in service be held regularly by GKJ Klasis Timur Jakarta.

Keywords: commitment to serve
IPTEKS BAGI MASYARAKAT: PEMBERDAYAAN UKM MELALUI KEMITRAAN DENGAN PEMERINTAH KABUPATEN SERANG DALAM KEGIATAN SOSIALISASI E-COMMERCE
Authors: Suadhana Rai I Nyoman Aji , Putri Sindy Yulia , Astuti Wiwiek Rukmi Dwi 
Published: March 2021

Abstrak
Usaha Kecil Menengah di Kabupaten Serang merupakan salah satu faktor penunjang pertumbuhan ekonomi rakyat. Namun UKM Serang masih menghadapi berbagai masalah. Sentralitas UKM dalam pertumbuhan ekonomi tidak berbanding lurus dengan kapasitas SDM/tenaga kerja UKM dalam memanfaatkan teknologi, terlebih lagi di era revolusi industri 4.0 saat ini. Tenaga kerja masih belum memahami sepenuhnya bagaimana memanfaatkan teknologi untuk meningkatkan penetrasi pasar dan promosi produk. Padahal, melalui e-commerce, UKM dapat menyebarkan informasi lebih luas kepada masyarakat, sehingga masyarakat dapat mengetahui deskripsi produk-produk UKM. Produk-produk tersebut memiliki kualitas yang baik, namun karena rendahnya promosi dengan memanfaatkan teknologi dan media sosial, penjualan produk menjadi kurang maksimal. Maka dari itu, program Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk meningkatkan minat dan pemahaman pelaku usaha UKM dalam memanfaatkan teknologi e-commerce untuk berniaga. Melalui program PkM akan diupayakan transfer of knowledge mengenai pemanfaatan e-commerce untuk meningkatkan potensi UKM Kabupaten Serang. Metode yang digunakan adalah sosialisasi dan tanya jawab/diskusi dengan mengimplementasikan pendekatan cooperative learning untuk para peserta. Hasil dari program PkM ini adalah adanya peningkatan minat dan pemahaman pelaku usaha UKM dalam mengoperasionalisasi gawai untuk meningkatkan intensitas promosi produk UKM agar lebih dikenal di masyarakat dunia nyata maupun dunia maya.
Kata Kunci: E-commerce; Pemerintah Kabupaten Serang; UKM
Abstract
UKM needs to prepare itself to be involved in production chains of regional scale. UKM in Serang Regency is one of the factors supporting people’s economic growth. But in reality, the centrality of UKM is not directly proportional to the human resources capacity of UKM in utilizing the technology, especially in the current era of industrial revolution 4.0. Workers still do not fully understand how to use technology to increase market penetration and product promotion. They also do not understand, how e-commerce runs. In fact, through e-commerce, UKM can disseminate information more widely to the public, so that people can find out descriptions of UKM products. These products have good quality, but the low promotion is still happening. Workers of UKM have minim access and capability to use technology and social media, so that product sales are not optimal. Through this program Pengabdian kepada Masyarakat (PkM), our team have been sharing how UKM internet and social media use could. Also, they can understand the knowledge transfer and technology transfer in industrial world. This PkM have partnership with Dinas Koperasi, Perindustrian, dan Perdagangan (Diskoperindag) Serang.
Keywords: E-commerce; Pemerintah Kabupaten Serang; UKM
Peningkatan Kesadaran Masyarakat terhadap Kerusakan Bangunan dan Lingkungan Pasca Gempa, Tsunami dan Likuifaksi di Palu Sulawesi Tengah
Authors: LE Hutabarat , P Simanjuntak , S Tampubolon 
Published: March 2021

Abstrak
Kejadian Gempa Palu pada tanggal 28 September 2018 telah menimbulkan korban jiwa dan kerugian besar dengan kerusakan pada infrastruktur dan bangunan di tiga daerah Palu, Sigi dan Donggala. Tragedi ini diakibatkan oleh magnitudo gempa yang sangat kuat M 7.4 diikuti oleh tsunami dan peristiwa likuifaksi yang sangat dahsyat. Karena itulah perlu dilakukan survey berikut assesmen data kerusakan bangunan yang terjadi di Palu sekaligus penyuluhan terkait teknis bangunan rumah tinggal tahan gempa. Sesuai hasil survei, likuifaksi terjadi di tiga lokasi yaitu Petobo, Balaroa dan Sigi. Sedangkan tsunami terjadi di pesisir pantai Donggala akibat terjadinya keruntuhan massa tanah yang besar saat terjadi likuifaksi. Beberapa bangunan dan infrastruktur yang mengalami kerusakan disebabkan oleh sifat teknis bangunan yang tidak mampu menahan beban gempa. Secara umum para warga warga Palu dan Sekitarnya di Sulawesi Tengah belum sepenuhnya memahami konsep bangunan tahan gempa khususnya untuk rumah tinggal sederhana.
Kata Kunci: likuifaksi, tsunami, kerusakan bangunan, survei, asessemen
Abstract
The Palu earthquake on 28 September 2018 caused heavy casualties and losses with damage to infrastructure and buildings in three areas which are Palu, Sigi and Donggala. This tragedy was an impact of a very strong earthquake magnitude 7.4 followed by a tsunami and a very terrible liquefaction. It was necessary to conduct a survey following the assessment of building damage data that occurred in Palu as well as technical assistance to understand the earthquake resistant residential buildings concept. Based on the survey results, liquefaction occurred in three locations namely Petobo, Balaroa and Sigi. While the tsunami occurred on the coast of Donggala due to large land mass collapse during liquefaction. Some buildings and infrastructure that were damaged due to the lack of technical requirement of the earthquake loads resistancy building. In general, the society of Palu and the surrounding areas were not having adequate knowledable for the concept of earthquake resistant buildings, especially for simple residential buildings.
Keywords:. liquefaction, tsunami, building damage, surveys, assessments
Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats
Authors: Meng Ke , Cai Huabo , Cai Simin , Hong Yucai , Zhang Xiaoming 
Published: March 2021

Background: Accumulating evidence suggested that bone marrow mesenchymal stem cells (BMSCs) have therapeutic potential for diabetes and heart diseases. However, the effects of BMSC on reducing myocardial fibrosis need to be optimized. This study aimed to investigate the mechanism of adiponectin (APN) modified BMSCs on myocardial fibrosis in diabetic model in vivo and in vitro.Methods: The high-fat diet combined with streptozotocin (STZ) injection were used to induced diabetic rat model. H9c2 cells were cultured under a high glucose medium as in vitro model. The BMSCs were modified by APN plasmid or APN small interfering RNA (siRNA), then transplanted to the diabetic rats by a single tail-vein injection, or co-cultured with H9c2 cells.Results: We demonstrated that diabetic rats showed typical diabetic symptoms, such as decreased cardiac function, accumulation of pathological lesions and collagen expression. However, these impairments were significantly prevented by the APN modified BMSCs treatment while no effects on APN siRNA modified BMSCs treated diabetic rats. Moreover, we confirmed that APN modified BMSCs could attenuate the expression of TGF-beta1/smad to suppress the myocardial fibrosis in the diabetic rats and high glucose induced H9c2 cells.Conclusion: The present results for the first time showed that APN modified BMSCs exerted protection on cardiac fibrosis via inhibiting TGF-beta1/smad signal pathway in diabetic rats. Our findings suggested that APN modified BMSCs might be a novel and optimal therapy for the diabetic cardiomyopathy in future.
The Oral Microbiome in Periodontal Health
Authors: Lenartova Magdalena , Tesinska Barbora , Janatova Tatjana , Hrebicek Ondrej , Mysak Jaroslav , Janata Jiri , Najmanova Lucie 
Published: March 2021

The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained image of “healthy OM” can be distorted.To overcome this bias, we taxonomically characterized the OM in almost a hundred young students of dentistry with precise oral hygiene and no signs of periodontal disease. We compared the results with the OM composition of older periodontally healthy individuals and also a group of patients with severe periodontitis (aggressive periodontitis according to former classification system). The clustering analysis revealed not only two compact clearly separated clusters corresponding to each state of health, but also a group of samples forming an overlap between both well-pronounced states. Additionally, in the cluster of periodontally healthy samples, few outliers with atypical OM and two major stomatotypes could be distinguished, differing in the prevalence and relative abundance of two main bacterial genera: Streptococcus and Veillonella. We hypothesize that the two stomatotypes could represent the microbial succession from periodontal health to starting dysbiosis. The old and young periodontally healthy subjects do not cluster separately but a trend of the OM in older subjects to periodontitis is visible. Several bacterial genera were identified to be typically more abundant in older periodontally healthy subjects.
Comprehensive Analysis of the Transcriptome-Wide m6A Methylome of Heart via MeRIP After Birth: Day 0 vs. Day 7
Authors: Yang Chuanxi , Zhao Kun , Zhang Jing , Wu Xiaoguang , Sun Wei , Kong Xiangqing , Shi Jing 
Published: March 2021

Aim: To systematically classify the profile of the RNA m6A modification landscape of neonatal heart regeneration.Materials and Methods: Cardiomyocyte proliferation markers were detected via immunostaining. The expression of m6A modification regulators was detected using quantitative real-time PCR (qPCR) and Western blotting. Genome-wide profiling of methylation-modified transcripts was conducted with methylation-modified RNA immunoprecipitation sequencing (m6A-RIP-seq) and RNA sequencing (RNA-seq). The Gene Expression Omnibus database (GEO) dataset was used to verify the hub genes.Results: METTL3 and the level of m6A modification in total RNA was lower in P7 rat hearts than in P0 ones. In all, 1,637 methylation peaks were differentially expressed using m6A-RIP-seq, with 84 upregulated and 1,553 downregulated. Furthermore, conjoint analyses of m6A-RIP-seq, RNA-seq, and GEO data generated eight potential hub genes with differentially expressed hypermethylated or hypomethylated m6A levels.Conclusion: Our data provided novel information on m6A modification changes between Day 0 and Day 7 cardiomyocytes, which identified that increased METTL3 expression may enhance the proliferative capacity of neonatal cardiomyocytes, providing a theoretical basis for future clinical studies on the direct regulation of m6A in the proliferative capacity of cardiomyocytes.
Should Pediatric Endocrinologists Consider More Carefully When to Perform a Stimulation Test?
Authors: Penco Arturo , Bossini Benedetta , Giangreco Manuela , Vidonis Viviana , Vittori Giada , Grassi Nicoletta , Pellegrin Maria Chiara , Faleschini Elena , Barbi Egidio , Tornese Gianluca 
Published: March 2021

IntroductionPediatric endocrinology rely greatly on hormone stimulation tests which demand time, money and effort. The knowledge of the pattern of pediatric endocrinology stimulation tests is therefore crucial to optimize resources and guide public health interventions. Aim of the study was to investigate the distribution of endocrine stimulation tests and the prevalence of pathological findings over a year and to explore whether single basal hormone concentrations could have saved unnecessary stimulation tests.MethodsRetrospective study with data collection for pediatric endocrine stimulation tests performed in 2019 in a tertiary center.ResultsOverall, 278 tests were performed on 206 patients. The most performed test was arginine tolerance test (34%), followed by LHRH test (24%) and standard dose Synachthen test (19%), while the higher rate of pathological response was found in insulin tolerance test to detect growth hormone deficiency (81%), LHRH test to detect central precocious puberty (50%) and arginine tolerance test (41%). No cases of non-classical-congenital adrenal hyperplasia were diagnosed. While 29% of growth hormone deficient children who performed an insulin tolerance test had a pathological peak cortisol, none of them had central adrenal insufficiency confirmed at low dose Synacthen test. The use of basal hormone determinations could save up to 88% of standard dose Synachthen tests, 82% of arginine tolerance + GHRH test, 61% of LHRH test, 12% of tests for adrenal secretion.ConclusionThe use of single basal hormone concentrations could spare up to half of the tests, saving from 32,000 to 79,000 euros in 1 year. Apart from basal cortisol level &lt;108 nmol/L to detect adrenal insufficiency and IGF-1 &lt;-1.5 SDS to detect growth hormone deficiency, all the other cut-off for basal hormone determinations were found valid in order to spare unnecessary stimulation tests.
Case Report: Single Dose Anti-PD1 in a Patient With Metastatic Melanoma and Cardiac Allograft
Authors: Goodman Amy E. , Karapetyan Lilit , Pugliano-Mauro Melissa , Levenson Joshua E. , Luke Jason J. 
Published: March 2021

BackgroundImmune-checkpoint inhibition has improved outcomes in metastatic melanoma. However, limited data describes the safety and efficacy of this treatment in the setting of cardiac allograft. Emerging translational and clinical evidence suggests that the majority of the benefit from these therapies is driven by the initial dose(s), and that attenuated dosing schedules may be as effective as continuous treatment.Case presentationWe present a case vignette of a cardiac transplant recipient with metastatic melanoma who experienced six months of clinical benefit after one dose of pembrolizumab and did not suffer allograft rejection.ConclusionThis case adds to the current available literature on the administration of checkpoint inhibitors in patients with cardiac allografts. Further, it explores potential markers of immunotherapy response and supports the potential of shorter or individualized immune-checkpoint blockade dosing strategies.