bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengujian Kembali Volatilitas Kebijakan Trilemma Terhadap Variabel Makroekonomi di Indonesia
Authors: Syamsudin Moch. 
Published: May 2021

The trilemma policy is a hypothesis stating a Mundell-Fleming macroeconomic development framework in which there is a state that cannot simultaneously choose three policies because it must sacrifice one policy so that the realization of policies that leads to economic stability is desired. The research aims to see the effect of the policy volatility on macroeconomic variables in Indonesia. The method used is the vector error correction model (VECM). The results show that the volatility of the trilemma policy adopted by Indonesia in the short and long term Affects the rate of economic growth and inflation. Economic shocks and uncertainties in the world economy externally affect macroeconomic variables. Viewing the results of forecasting for the trilemma policy and macroeconomic variables show that the inflation rate is so high and the level of economic openness is very low. This result recommends that there is a need for harmonization of policies undertaken by Bank Indonesia as the monetary authority and the government as a fiscal authority so as to achieve the level of financial stability that impacts on economic stability.
Keywords: Trilemma Policy, Macroeconomics, Vector Error Correction Model (VECM), Forecasting
Investasi Syariah dan Pertumbuhan Ekonomi: Optimasi Peran Sukuk Sebagai Penunjang Pembangunan Ekonomi Nasional
Authors: Wijaya Reza Henning 
Published: May 2021

Massive movement of sharia things in the world, it given impact to all of countries, no exception Indonesia. This descriptive research aims to depict sharia investement especially sukuk able to contribute in national economy development. This research method is qualitative with library research. Sukuk able to cover deficit Indonesia APBN to support infrastructure developing, built labor insentive, and developing region potency. But Indonesia still needs some regulations and policies to optimize role of sukuk in national economy development itself.
Keywords: Sukuk, National Economy Development, APBN.
A Recurrent Neural Network–Based Proxy Model for Well-Control Optimization with Nonlinear Output Constraints
Authors: Kim Yong Do , Durlofsky Louis J. 
Published: May 2021

Summary
In well-control optimization problems, the goal is to determine the time-varying well settings that maximize an objective function, which is often the net present value (NPV). Various proxy models have been developed to predict NPV for a set of inputs such as time-varying well bottomhole pressures (BHPs). However, when nonlinear output constraints (e.g., maximum well/field water production rate or minimum well/field oil rate) are specified, the problem is more challenging because well rates as a function of time are required. In this work, we develop a recurrent neural network (RNN)–based proxy model to treat constrained production optimization problems. The network developed here accepts sequences of BHPs as inputs and predicts sequences of oil and water rates for each well. A long-short-term memory (LSTM) cell, which is capable of learning long-term dependencies, is used. The RNN is trained using well-rate results from 256 full-order simulation runs that involve different injection and production-well BHP schedules. After detailed validation against full-order simulation results, the RNN-based proxy is used for 2D and 3D production optimization problems. Optimizations are performed using a particle swarm optimization (PSO) algorithm with a filter-based nonlinear-constraint treatment. The trained proxy is extremely fast, although optimizations that apply the RNN-based proxy at all iterations are found to be suboptimal relative to full simulation-based (standard) optimization. Through use of a few additional simulation-based PSO iterations after proxy-based optimization, we achieve NPVs comparable with those from simulation-based optimization but with speedups of 10 or more (relative to performing five simulation-based optimization runs). It is important to note that because the RNN-based proxy provides full well-rate time sequences, optimization constraint types or limits, as well as economic parameters, can be varied without retraining.
NOTE: This paper is published as part of the 2021 Reservoir Simulation Conference Special Issue.
Salivary protein glycopatterns for natural regulation of oral microbiota
Authors: Shu Jian , Yu Hanjie , Wang Yan , Wang Xilong , Ren Xiameng , Zhang Kun , Tang Zhen , Chen Wentian , Li Baozhen , Li Zheng 
Published: May 2021

Abstract
Background：Little is known about the relationship between salivary protein glycopatterns and oral microbial communities in the patients of gastric cancer (GC) and type 2 diabetes mellitus (T2DM).Methods：In this study, the oral microbiome of healthy volunteers (HVs) and GC patients were detected using 16S rDNA sequencing. The Fucose-neoglycoproteins were synthesized and used to explore the effects of Fucose moiety against Aggregatibacter segnis (A. segnis). The sialoglycoproteins were isolated and used to assess the role of the Siaα2-3/6Gal-linked glycans against Candida albicans (C. albicans).Findings：The results showed that five species (e.g. A. segnis, Megasphaera micronuciformis) were significantly increased (p<0.05) while two species (Streptococcus salivarius and Oral taxon 870) were significantly decreased (p<0.01) in the saliva of GC patients compared to HVs. The adhesion of A. segnis could be inhibited by 30 μg/mL of fucose-neoglycoproteins. The growth and adhesion of C. albicans could be inhibited gradually by 50-400 μg/mL sialoglycoproteins. And Siaα2-3Gal moieties played a major role against the growth and adhesion of C. albicans.Interpretation：These findings provide a novel theory that dynamic communities of oral microbiota are regulated naturally by host salivary protein glycopatterns, having important implications for developing new carbohydrate drugs for oral and body health. Funding：This study was supported by the National Natural Science Foundation of China (Grant No. 81871955), the China Postdoctoral Science Foundation (Grant No. 2020M673628XB), and the Natural Science Foundation of Shaanxi Province (Grant No. 2021JQ-446).
Impact of a Health Educational Interventional Program on Reducing the Head Lice Infestation Among Pupils in an Elementary School of a Sub-Tropical Region
Authors: Najjari Mohsen , Gorouhi Mohammad Amin , Zarrinfar Hossein , Farash Bibi Razieh Hosseini , Jamali Jamshid , Moghaddas Elham , Ebrahimipuor Mohammad 
Published: May 2021

Abstract
Background: Pediculosis is an important social challenge that can be caused by human head louse, Pediculus humanus capitis. This infestation is cosmopolitan, especially in countries with low hygiene and sanitation. Regular health education classes for students and their parents are required to reducing this infestation in schools and families. This study aimed to evaluate the impact of a health education intervention program on reducing of head lice among pupils of an elementary school.Methods: In a pre-post study, a total of 594 pupils, a girl elementary school, were screened for pediculosis (2017-2018). The prevalence of pediculosis estimated before and after two month interventional education program. Visual inspection was applied for initial diagnosis of infection. The suspected cases were confirmed by wood lamp examination and potassium hydroxide (KOH) microscopic wet‐mount examination. An elementary school in the same area was selected as the control group, with no interference. The prevalence of contamination by the same method was obtained in the study group.Results: At the beginning of study, pre-intervention prevalence of pediculosis among pupils was 8.4% (49/594). The mean age in all pupils was 9.86±1.83 years old and the most infestation was showed in fourth-grade students with 10 years old. Analysis of statistics demonstrated a significance difference between having infestation and the number of members in the families. Post-intervention phase led to a decreased prevalence of pediculosis in pupils to 3% (8/594) (p-value < 0.05) and significant increase of parental knowledge on prevention program of pediculosis (p-value < 0.001), Conclusion: The prevalence of pediculosis was significantly reduced following the interventions in the school. The applied interventions may be implemented in other residual centers to get rid of this important infestation.
Python-based Fuzzy Control of Ore Feeding System
Authors: Du Yu , Liu Yuebing , Liu Dan , Liu Ruitao , Zhang Wenkang , Yu Longzhou 
Published: May 2021

Abstract
Using Python as a programming language, this study investigates the problem of controlling the ore amount in the field of mineral processing. First, data on the influencing factors collected from a certain beneficiation mill in Yuanyang are quantitatively analyzed using the NumPy module library. Factors having a greater influence are screened out and then selected as the input while the motor frequency is generated as the output by the fuzzy control algorithm developed using the SciKit Fuzzy module library. The range of values of the fuzzy control variable is defined, the fuzzy membership function is generated, and the fuzzy control rule is established. Finally, the fuzzy controller is activated to realize fuzzy control of the mine. The NumPy algorithm can be effectively applied to the quantitative analysis of data, and the calculation results are reasonable and interpretable. The simulation results are as follows: the hardness of the raw ore and the weight of the belt scale are the key factors for controlling the ore amount, and they can be used as the input variables of the fuzzy control system. The fuzzy controller developed using the SciKit Fuzzy module library can be effectively applied to the field of mineral processing, and it overcomes the limitations of current computer technology in industrial mineral processing.
RUFY3 and RUFY4 are ARL8 effectors that couple lysosomes to dynein-dynactin
Authors: Keren-Kaplan Tal , Saric Amra , Ghosh Saikat , Williamson Chad , Jia Rui , Li Yan , Bonifacino Juan 
Published: May 2021

Abstract
The small GTPase ARL8 associates with lysosomes and recruits several effectors that mediate coupling to kinesins for anterograde transport, as well as tethering for eventual fusion with other organelles. Herein we report the identification of the “RUN- and FYVE-domain-containing” proteins RUFY3 and RUFY4 as novel ARL8 effectors that couple lysosomes to dynein-dynactin for retrograde transport. Using various biochemical approaches, we find that RUFY3/4 interact with both GTP-bound ARL8 and dynein-dynactin. In addition, we show that RUFY3/4 are both necessary and sufficient for concentration of lysosomes in the juxtanuclear area of the cell. RUFY3/4 also promote retrograde transport of lysosomes in the axon of hippocampal neurons. The function of RUFY3/4 in retrograde transport is required for juxtanuclear redistribution of lysosomes upon serum starvation or cytoplasmic alkalinization, and may underlie the reported roles of RUFY3/4 in axon development/degeneration, cancer and immunity. These studies thus establish RUFY3/4 as novel ARL8-dependent, dynein-dynactin adaptors, and highlight the role of ARL8 in the regulation of both anterograde and retrograde lysosome transport.
Exploring the Effects of Climate-related Financial Policies on Carbon Emissions in G20 Countries: A Panel Quantile Regression Approach
Authors: D'Orazio Paola , Dirks Maximilian 
Published: May 2021

Abstract
This paper studies the effects of financial development, economic growth, and climate-related financial policies on carbon (CO 2 ) emissions for G20 countries. The focus is on policies implemented to different degrees by G20 countries to scale up green finance and address climate-related financial risks in 2000-2017 and represents this paper’s value-added. The empirical results obtained by relying on the panel quantile regression approach indicate that the impacts of the different explanatory variables on carbon emission are heterogeneous. Specifically, the effect of the stock of short-term financial policies on carbon emissions is negative, and its effect becomes smaller at higher quantiles. No significance is reported for the 10th quantile. The stock of long-term policies also show significant negative coefficients, but their impact is stronger for higher quantiles. Financial development contributes to improving environmental quality, and its impact is larger in higher emission countries. Energy consumption increases carbon emissions, with the strongest effects occurring at higher quantiles. Our results also support the validity of the EKC relationship and positive effects of GDP and population on high emissions levels. The study highlights that climate-related financial policies have a negative direct effect on CO 2 emissions but a positive indirect effect in some percentiles. This evidence can imply a worsening of environmental quality in high-emission countries when considering the stock of short-term policies and low-emission countries when analyzing the stock of long-term policies. The total effect appears nevertheless negative, which indicates that these policies may improve environmental quality overall in G20 countries.
Survival, Virulence Gene Expression and Difference in the Drug Susceptibility of Non-typhoidal Salmonella in Gut Physiological Conditions
Authors: Kotian Akshatha , Aditya Vankadari , Sheikh Jassiya , Saikrishnan Sreya , Rai Praveen , Chakraborty Anirban , Karunasagar Indrani , Deekshit VK 
Published: May 2021

Abstract
Salmonella is one among the most versatile and resilient enteric pathogens that known to have developed various survival strategies within the host system. The ability of the bacteria to circumvent the physiological parameters as well as dodge the antimicrobial stress environment within the host is one of the most crucial steps in establishing an infection. With an alarming rise in multi-drug resistant serovars of non-typhoidal Salmonella and lack of vaccine for combatting the infections, behaviour of the bacteria in the presence of host physiological gut conditions (NaCl, high and low iron) and antibiotics will help in understanding the survival strategies as well as mechanisms of resistance. 59 non-typhoidal Salmonella serovars isolated from poultry and seafood were used in the study. The isolates were screened for their antibiotic susceptibility patterns. Two multi-drug resistant and two sensitive serovars were used for growth kinetics and virulence gene expression study. The results obtained revealed that despite similar resistance pattern, the effect of individual class of antibiotics on the growth of serovars varied. On contrary, no significant difference was observed in growth pattern on exposure to in vitro gut like experimental conditions. Nevertheless, the in-vitro gut conditions and exposure to antibiotics have drastically reduced the minimum inhibitory concentration of antibiotics in resistant strains. A first of its kind study that draws attention on the significant effect of antibiotics and gut physiological conditions on MIC and expression of virulence genes from Salmonella pathogenicity island (SPI) 1 and 2 between resistant and sensitive non typhoidal Salmonella serovars.
A meta-analysis of Twitter assisted learning outcomes in terms of country, gender, and Twitter usage
Authors: Yu Zhonggen 
Published: May 2021

Abstract
The use of social media such as Twitter has been widely used in education due to their positive learning outcomes. To summarize the effect of Twitter use on educational outcomes, this study included 22 high-quality peer-reviewed journal articles for meta-analysis. It is concluded that the Twitter assisted learning approach can lead to significantly higher learning outcomes than the non-Twitter assisted but the former cannot lead to significantly higher teaching effectiveness than the latter. The use of Twitter can improve learning outcomes in the USA and Sweden rather than Spain. Twitter can significantly improve learning engagement in the USA but not in Greece. Males tend to show significantly higher learning outcomes than females in the Twitter assisted learning context. Whether Twitter is used as a supplementary or an integrated tool can significantly improve learning outcomes. Future research may adopt more interdisciplinary methods and include more literature to summarize the effect of Twitter use on educational outcomes.
Preparation and Application of Sewage Sludge Bio-char/zero Valent Iron (SSBC/ZVI) Composite for Improving the Biodegradability of a Real Chemical Synthesis-based Pharmaceutical Wastewater
Authors: Qi Gaoxiang , Wang Xiaobo , Liu Xuecheng , Yu Shen 
Published: May 2021

Abstract
A new kind of micro-electrolysis filler sewage sludge biochar/zero violent iron (SSBC/ZVI) composite was prepared for a real chemical synthesis based pharmaceutical wastewater (CSPW) pretreatment for improving the biodegradation index (BI). The optimal operation condition of micro-electrolysis system was obtained at HRT of 2 h, the initial pH of 3.0 and filler dosage of 100 g/L, with COD removal rate of 30.5%. Comparative analysis of raw and used SSBC/ZVI filler, GC-MS analysis of raw and treated pharmaceutical wastewater suggested that the pollutants removal was mainly attributed to the combination of reduction and oxidation, absorption of SSBC and flocculation effect of iron sludge. In addition, SSBC/ZVI exhibited relative high stability and excellent reusability for COD removal and BI improvement of real pharmaceutical wastewater. The results of this study provide new ideas of sewage sludge utilization for real wastewater pretreatment.
A Comparative Analysis of L1 Retrotransposition Activities in Human Genomes Suggests an Ongoing Increase in L1 Number Despite an Evolutionary Trend Towards Lower Activity
Authors: Wehbi Sawsan Sami , zu Dohna Heinrich 
Published: May 2021

Abstract
BackgroundLINE-1 (Long Interspersed Nuclear Elements, L1) retrotransposons are the only autonomously active transposable elements in the human genome. The evolution of L1 retrotransposition rates and its implications for L1 dynamics are poorly understood. Retrotransposition rates are commonly measured in cell culture-based assays, but it is unclear how well these measurements provide insight into L1 population dynamics. This study applied comparative methods to estimate parameters for the evolution of retrotransposition rates, and infer L1 dynamics from these estimates.ResultsOur results show that the rates at which new L1s emerge in the human population correlate positively to cell-culture based retrotransposition activities, that there is an evolutionary trend towards lower retrotransposition activity, and that this evolutionary trend is not sufficient to counter-balance the increase in L1s resulting from continuing retrotransposition. ConclusionsTogether, these findings support a model of the population-level L1 retrotransposition dynamics that is consistent with prior expectations and indicate the remaining gaps in the understanding of L1 dynamics in human genomes.
Robust effects of springtime Arctic ozone depletion on surface climate
Authors: Friedel Marina , Chiodo Gabriel , Stenke Andrea , Domeisen Daniela , Fueglistaler Stephan , Anet Julien , Peter Thomas 
Published: May 2021

Abstract
Massive spring ozone loss due to anthropogenic emissions of ozone depleting substances is not limited to the austral hemisphere, but can also occur in the Arctic. Previous studies have suggested a link between springtime Arctic ozone depletion and Northern Hemispheric surface climate, which might add surface predictability. However, so far it has not been possible to isolate the role of stratospheric ozone from dynamical downward impacts. For the first time, we quantify the impact of springtime Arctic ozone depletion on surface climate using observations and targeted chemistry-climate model experiments to isolate the effects of ozone feedbacks. We find that springtime stratospheric ozone depletion is followed by surface anomalies in precipitation and temperature resembling a positive Arctic Oscillation. Most notably, we show that these anomalies, affecting large portions of the Northern Hemisphere, cannot be explained by dynamical variability alone, but are to a significant degree driven by stratospheric ozone. The surface signal is linked to reduced shortwave absorption by stratospheric ozone, forcing persistent negative temperature anomalies in the lower stratosphere and a delayed breakup of the polar vortex - analogous to ozone-surface coupling in the Southern Hemisphere.These results suggest that Arctic stratospheric ozone actively forces springtime Northern Hemispheric surface climate and thus provides a source of predictability on seasonal scales.
Amateur Singing Benefits Speech Perception in Aging Under Certain Conditions of Practice: Behavioural and Neurobiological Mechanisms.
Authors: Tremblay Pascale , Perron Maxime , Vaillancourt Josée 
Published: May 2021

Abstract
Limited evidence has shown that practising musical activities in aging, such as choral singing, could lessen age-related speech perception in noise (SPiN) difficulties. However, the robustness and underlying mechanism of action of this phenomenon remain unclear. In this study, we used surface-based morphometry combined with a moderated mediation analytic approach to examine whether singing-related plasticity in auditory and dorsal speech stream regions can mitigate age-related SPiN difficulties. 36 choral singers and 36 non-singers aged 20–87 years underwent cognitive, auditory, and SPiN assessments. Our results provide important new insights into experience-dependent plasticity by revealing that, under certain conditions of practice, amateur choral singing is associated with age-dependent structural plasticity within auditory and dorsal speech regions, which is associated with better SPiN performance in aging. Specifically, the conditions of practice that were beneficial for SPiN included frequent weekly practice at home, several hours of weekly group singing practice, singing in multiple languages, and having received formal singing training. These results suggest that the effect of amateur choral singing on SPiN is related to a dual mechanism involving auditory processing and auditory-motor integration and may be dose dependent, with more intense singing associated with greater benefit. Our results thus reveal that the relationship between musical practice and SPiN is complex, and underscore the importance of considering musical practice behaviours in understanding the effects of musical activities on the brain-behaviour relationship.