bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Opportunities in Non-Preservative Glaucoma Therapy
Authors: Antonov A. A. , Kozlova I. V. , Vitkov A. A. 
Published: July 2021

Most of the medicines used for the treatment of glaucoma include a preservative in various concentrations. With long-term topical therapy, patients with glaucoma may develop dry eye syndrome (DES). The severity of symptoms depends on the number of drugs used and the presence of a preservative in them. Against the background of DES progression, compliance to glaucoma therapy may decrease, and, consequently, the effectiveness of the treatment may decrease. Currently, new non-preservative hypotensive drugs containing brimonidine, as well as a fixed combination (FC) of dorzolamide and timolol, are available on the market.Purpose: to compare assessment of the hypotensive effect and tolerability of preservative-free drugs FC Dorzolamid 20 mg/ml, Timolol 5 mg/ml (Dortmol Antiglau ECO) and Brimonidine 2 mg/ml (Brim Antiglau ECO) when switching from similar drugs containing a preservative in patients with compensated glaucoma.Patients and methods. In this prospective clinical study, 60 patients (60 eyes) with compensated primary open-angle glaucoma on combined topical therapy were examined. In group 1 (30 patients, 30 eyes), the combinations of dorzolamide / timolol or brinzolamide / timolol were switched with the non-preservative Dortmol Antiglau ECO. In group 2 (30 patients, 30 eyes), the brimonidine as part of the medication regimen were replaced with the non-preservative Brim Antiglau ECO. The level of corneal-compensated IOP was assessed before the switch in therapy and after 1 month. Subjective feelings and objective signs of the treatment’s use were monitored during examination and using a questionnaire, which was compiled to study the tolerance of therapy.Results. Switching to a preservative-free combination of dorzolamide and timolol resulted in a reduction in complaints of irritation, lacrimation, and foreign body sensation. The efficiency control did not reveal a significant change (p > 0.05) in the cornealcompensated intraocular pressure (IOPcc). When transferred to the Brim Antiglau ECO as part of the local hypotensive treatment, intraocular pressure decreased significantly (p < 0.05). The average total score characterizing drug intolerance, when evaluated by the patient, decreased by 2.4 times, by the attending physician-by 1.9 times. The degree of conjunctival hyperemia on the MacMonnies photographic scale decreased in both groups.Conclusion. Preservative-free drugs can be recommended for most patients with glaucoma as a starting treatment and as a replacement for current therapy.
Рossibilities of the Thermography in Early Diagnostics of Bleb Scarring (Prelimenary Report)
Authors: Makashova N. V. , Vasilyeva A. E. , Kolosova O. Yu. , Morozova N. E. 
Published: July 2021

Thermography is the method of noninvasive registration of visible image of the own infrared radiation of the human body surface by special devices. The physiological basis of its application in medical diagnostics is the amplification of infrared radiation intensity from pathologic spots that is connected with the enhancement of blood supply and metabolism.Purpose. To study the possibilities of thermography for functional bleb status assessment, for early diagnostics of bleb scarring processes and for definition of needling indications.Patients and methods. There were executed 32 thermography (32 patients and eyes) of blebs in 7 days after minimally invasive sinustrabeculectomy. Authors used thermal imaging Тesto 875-2i with SuperResolution technology and telephoto lens 9°×7°. The bleb area and temperature were studied With IRSoft and Universal Desktop Ruler programs. Intraocular pressure (corneal compensated) (IOPcc) was measured with Ocular Response Analyzer®, ORA.Conclusion. The study has shown the direct correlation dependence between bleb functional activity and its thermographic characteristics (area and temperature).
The Choice of Dry Eye Therapy Depending on Ocular Surface Condition
Authors: Yanchenko S. V. , Malyshev A. V. , Sakhnov S. N. 
Published: July 2021

Purpose: to develop approaches to differentiated substitution therapy in patients with dry eye (DE) of mild and moderate severity.Patients and methods. We examined 86 DE patients (22–45 years old; 38 men, 48 women). Group-1 included 54 patients (54 eyes) with mild DE under conditions of combined lipid-mucose-deficiency, group-2 32 patients (32 eyes) with moderate DE against the background of combined lipid-aqua-mucose-deficiency. Conducted: DE symptoms registration (OSDI scale); Norn and Shirmer-1 tests; OCT meniscometry; assessment of the Bijsterveld xerosis index and ‘lid-vipers’ symptom identification; Norn’s compression test. To assessment the therapy effectiveness, patients in both groups were divided into subgroups. Patients of subgroup 1.1 (18 eyes) carried out ‘fat-water’ type emulsion instillations, subgroup 1.2 (18 eyes) — 0.15 % sodium hyaluronate instillation (Hylabak®), subgroup 1.3 (18 eyes) — 3.0 % trehalose (Thealoz®) — 1–2 drops, 4 times a day. All persons included in group-1 were additionally recommended to apply 5.0 % dexpanthenol gel at night. Patients of subgroup 2.1 (16 eyes) received 0.15 % sodium hyaluronate instillation (Hylabak®), patients of subgroup 2.2 (16 eyes) 0.15 % sodium hyaluronate (Hylabak®) and 3.0 % trehalose (Thealoz®) instillation — 4 times a day. All patients included in group-2 were additionally recommended to apply ointment with vitamin A at night. The main criterion for the therapy effectiveness was the tear film brake up time (TBUT, s) two months after the start treatment. Statistical processing included: calculation the mean and its standard deviation (M ± s); assessment of the significance of differences (Wilcoxon’s t-test, KruskalWallis test, Mann-Whitney U-test).Results. In group-1 patients the following TBUT dynamics was recorded: in subgroup 1.1 — from 5.4 ± 0.5 to 6.2 ± 0.6 s (p < 0.05); in subgroup 1.2 — from 5.2 ± 0.4 to 6.6 ± 0.6 s (p < 0.05); in subgroup 1.3 — from 5.3 ± 0.5 to 7.1 ± 0.7 s (p < 0.05). The most pronounced TBUT increase was noted in subgroup 1.3 (trehalose instillation). In group-2, the increase in TBUT was: in subgroup 2.1 — from 3.5 ± 0.3 to 4.7 ± 0.3 s (p < 0.05); in subgroup 2.2 — from 3.4 ± 0.2 to 5.2 ± 0.4 s (p < 0.05). A significantly more pronounced TBUT increase was noted in subgroup 2.2 (sodium hyaluronate and trehalose instillation).Conclusion. In our opinion, differentiated approaches to DE replacement therapy may be included: for mild DE in conditions of lipid-mucose-deficiency — instillation of bioprotector based on 3.0 % trehalose (Thealose®); in case of moderate DE against the background of lipid-aqua-mucose-deficiency — 0.15 % sodium hyaluronate (Hylabak®) instillation in combination with a bioprotector based on 3.0 % trehalose (Thealoz®).
Uma análise do garantismo jurídico de Luigi Ferrajoli
Authors: Prazak Maurício Avila , Soares Marcelo Negri , Resende Julia Ribeiro de 
Published: July 2021

O presente estudo utiliza-se do método dedutivo e apresenta como tema analisar e ao mesmo tempo revisitar e refletir sobre a obra do Jurista Luigi Ferrajioli e sua teoria do Garantismo Jurídico. São múltiplas as obras deste estudioso e sua máxima se perpetua com a publicação de Diritto e ragione que finda por assumir importância expressiva no ordenamento jurídico contemporâneo. Assim sendo, procura-se revisitar as reflexões iniciais na década de 90 com as múltiplas questões teóricas e filosófico-politico. Trata-se, sinteticamente, de retornar as idéias iluministas que serviram de norteadoras para os escritos de Ferrajioli e que sempre primou pelo respeito ao ser humano, a dignidade humana e que a Lei possa ser aplicada sempre pautada nos valores humanos.
Drogas e políticas públicas: reflexões com ênfase na prevenção
Authors: Oliveira Sergio Paulo de , Oliveira Gilson Batista de 
Published: July 2021

O consumo de substâncias psicoativas acompanha a evolução da história da humanidade. O ser humano tem feito uso de drogas através dos tempos nos mais variados contextos e pelas mais diversas motivações, sendo que, na atualidade, verifica-se que essa utilização tem colocado muitos desafios à sociedade mundial. Tendo em vista que se trata de um fenômeno complexo e multifatorial, observa-se que as políticas públicas de enfrentamento a este problema não têm sido efetivas. No Brasil, em especial, as ações e programas neste sentido tem se demonstrado tardias, mínimas e desarticuladas. Dessa forma, a proposta deste trabalho é contribuir com reflexões teóricas acerca dessa questão, com particular ênfase ao âmbito da prevenção.
Levantamento epidemiológico bucal, auto estima e qualidade de vida de pacientes portadores do vírus HIV/AIDS: Estudo transversal exploratório
Authors: Garbin Clea Adas Saliba , Teruel Gabriela Peres , Gatto Renata Colturato , Saliba Tania Adas , Butarelo Ana Victória , Garbin Artênio José Ísper 
Published: July 2021

Objetivo: Objetivou-se avaliar nos pacientes portadores de HIV/AIDS a condição de saúde bucal, a autoestima, a qualidade de vida e verificar as possíveis associações entre elas. Metodologia: Trata-se de um estudo transversal, realizado no Serviço de Atendimento Especializado ligado a Faculdade de medicina. Para a coleta de dados foi realizado o exame bucal, o que foram utilizados os índices CPO-D e IHOS, preconizados pela Organização Mundial de Saúde e por meio da Escala de Autoestima de Rosenberg. A análise de dados foi aplicada o coeficiente de Correlação por Postos de Spearman, Teste G com correção de Williams e teste do Qui-Quadrado, no Programa SPSS 22.0. Resultados: Participaram da pesquisa 146 pacientes portadores de HIV, sendo a maioria do gênero masculino (61,64%), com idade média 44 anos e nível de escolaridade básico/fundamental, (50%). Em relação à saúde bucal o CPOD médio foi de 14,31 e o IHOS foi regular em 38,36% da amostra. A maior parte dos pacientes não apresentava sintomas de depressão (60,28%) e 52,06% apresentou uma autoestima positiva. A baixa autoestima apresentou correlação negativa com os domínios atividade sexual (p=0,005), satisfação com a vida (p=0,040) e conscientização sobre o HIV (p=0,026). Conclusão: Os resultados sugerem que a condição de saúde bucal foi considerada regular e a autoestima foi classificada como positiva, mas algumas variáveis interferiram negativamente nos domínios de qualidade de vida.
EXPERIMENTAL STUDY ON WASTEWATER TREATEMNT FROM AIR CONDITIONER PLANT OF CALEDONIAN COLLEGE OF ENGINEERING, OMAN
Authors: Alkaabi Salim Abdaliah Salim , Dwivedi Priy Brat 
Published: July 2021

Purpose of the study: Treatment of the wastewater coming from households, laboratories, big AC plants etc. is very important. For this the use of low cost activated carbon is highly preferable and eco-friendly making great improvements in the quality of wastewater also. The aim of this study is to clean the wastewater collected from Air Port Height Campus of Caledonian College of Engineering, by the use of activated carbon in batch process.
Methodology: Wastewater sample is collected from Airport height campus of CCE, Oman. It was treated using activated carbon in batch study, and the quality of water is tested in terms of % variation in COD in the college laboratory. Time, activated carbon dose, pH, and temperature variation were conducted on 50 ml batch size.
Main Findings: Maximum COD removal was 88% at carbon dose 0.2g, time 30 min, pH 5 and temperature 550C.The results obtained from experiments were also analysed by Langmuir and Freundlich isotherm. Results shows that the process fit well with Freundlich isotherm because R2 values are higher for the linear relationships.
Applications of this study: The results obtained from the experiments clearly indicate that the quality of the treated water has improved and if some more parameters that are concerned with the purity factor can be introduced, this water can be made available in form of non-potable usage also. So, this study is highly beneficial for our earth as well as human beings.
Novelty/Originality of this study: The experiment performed is very eco-friendly as low cost and easily available chemicals and activated carbon is used here, so it will relieve us from the expensive and complicated methods for wastewater treatment.
THE EFFECT OF WORKPLACE SPIRITUALITY ON AFFECTIVE COMMITMENT AND TURNOVER INTENTION: CASE STUDY ON CONSTRUCTION INDUSTRY
Authors: Salim Najmy Haqq , Wijayanti Dewie Tri , Witjaksono Andre Dwijanto 
Published: July 2021

Purpose of the study: This study aims to analyze the relationship between the dimensions of workplace spirituality, organizational commitment, and turnover intention in the construction industry in Surabaya, Indonesia.
Methodology: This study uses a quantitative approach. This research was conducted on a sample of seventy-four employees in eight companies in the Surabaya Construction Industry. The analysis of research uses the Structural Equation Modeling (SEM) - Partial Least Square (PLS) analysis method.
Main Findings: The results showed a significant positive effect of meaningful work, a sense of community, alignment with organizational values as working spirituality dimensions​​ on affective commitment. Meanwhile, there is a negative and significant effect of meaningful work, sense of community and alignment with organizational values, and affective commitment on turnover intention.
Social implication: The results of this study are expected to provide benefits as a basis for further research in examining the dimensions of workplace spirituality, affective commitment, and return intention and practically as a basis for making other business decisions in reducing turnover intention in the field of corporate human resource management.
Novelty/originality of this study: Compared to previous studies examining the impact of working spirituality and organizational commitment partially on turnover intention and more research on the impact of working spirituality on job satisfaction, this study focuses on the analysis of the impact of organizational commitment and working spirituality on turnover intention is still rarely studied.
THERMAL PERFORMANCE EVALUATION OF GREEN LIVING WALLS IN COMPOSITE CLIMATE
Authors: Sharad Nagdeve Shruti , Manchanda Shweta , Dewan Anil 
Published: July 2021

Purpose of the study: Due to high solar radiation and extreme heat gain in composite climates, the envelope or the façade of the building becomes an essential part to modulate the heat transfer and temperature in the indoor environment. A passive sustainable approach to tackle heat gain is by adopting green living facades as the exterior skin. The objective of this research is to identify the potential of green living walls in modulating temperature and relative humidity in the composite climate of India.
Methodology: This research is based on data collection in the form of a Case Study. The paper evaluates the difference of variation in temperature and relative humidity of two façade samples of the same building, one with a “green living facade” and one without it.
Main Findings: The research aimed to justify that a green living facade may act as a passive strategy for composite climates. The result demonstrated that there is a significant temperature reduction between the ambient air temperature and indoor room temperature. The result also showed a notable change between ambient air temperature and the gap between the green living façade and the surface of the wall.
Implications: Significant drop in indoor ambient temperature in composite climate may save energy for cooling or heating demands.
Application of this study: This is a pilot study in order to carry out the main study for a similar application in order to categorize this as a passive sustainable façade strategy.
Novelty/Originality of this study: The study is one of its kind attempt to investigate the impact of vertical green walls on thermal comfort in the composite climate of India.
ρ-PROJECTIVE AND σ-INVOLUNTARY VARIATIONAL INEQUALITIES AND IMPROVED PROJECTION METHOD FOR PROJECTED DYNAMICAL SYSTEM
Authors: Mitra Siddharth , Das Prasanta Kumar 
Published: July 2021

Purpose of study: To introduce the concept of projective and involuntary variational inequality problems of order and respectively. To study the equivalence theorem between these problems. To study the projected dynamical system using self involutory variational inequality problems.
Methodology: Improved extra gradient method is used.
Main Finding: Using a self-solvable improved extra gradient method we solve the variational inequalities. The algorithm of the projected dynamical system is provided using the RK-4 method whose equilibrium point solves the involutory variational inequality problems.
Application of this study: Runge-Kutta type method of order 2 and 4 is used for the initial value problem with the given projected dynamical system with the help of self involutory variational inequality problems.
The originality of this study: The concept of self involutory variational inequality problems, projective and involuntary variational inequality problems of order and respectively are newly defined.
“Services to Empower YOU” – Interfaces Multimodais Inclusivas numa Plataforma de Serviços para Pessoas com Deficiência ou Incapacidade
Authors: MACEDO PATRICIA , MADEIRA RUI NEVES , MIRANDA PAULA , CASTRO CATARINA , PAQUETE PATRICIA , FERRADA FILIPA , SANTOS PEDRO ALBUQUERQUE 
Published: July 2021

Services to Empower YOU” (SEU) responde a um desafio societal que visa fornecer a pessoas com deficiência ou incapacidade uma ferramenta agregadora e inclusiva através da qual possam requisitar com confiança serviços. Este artigo apresenta os resultados iniciais obtidos no projeto SEU que compreende o estudo da conceção e implementação de interfaces digitais adaptadas às necessidades específicas de cada utilizador, assim como o estudo de um modelo de negócio que permita aos prestadores de serviços fornecerem serviços para um público com características especiais. Partindo do levantamento das necessidades de pessoas com incapacidades e do estudo das normas de acessibilidade digital, especificou-se um Modelo de Adaptação para interfaces em função das características de cada tipo de utilizador e um Modelo de Serviços, que estende o modelo base de plataformas facilitadoras de serviços offline. Estes dois modelos foram aplicados no desenvolvimento do protótipo web apresentado.Palavras-chave: Plataforma de serviços web. Acessibilidade digital. Interfaces multimodais. Inclusão. Pessoas com deficiência ou incapacidade. "Services to Empower YOU" - Inclusive Multimodal Interfaces in a Service Platform for People with DisabilitiesAbstract: “Services to Empower YOU” (SEU) responds to a societal challenge that aims to provide people with disabilities with an aggregating and inclusive tool through which they can confidently request services that are appropriate to them. This article presents the initial results achieved in project SEU, which comprises the study of the design and implementation of digital interfaces adapted to the specific needs of each user, as well as the study of a business model that allows service providers to offer services for an audience with special characteristics. Starting from the survey of the needs of people with disabilities and the study of digital accessibility standards, two models were proposed: an Adaptation Model for designing interfaces according to the characteristics of each type of user; and a Services Model, which extends the base model of platforms facilitating offline services. These two models were instantiated in the initial web prototype presented.Keywords: Web services platform. Digital accessibility. Multimodal user-interfaces. Inclusion. People with disabilities.
DESIGNING THE PESANTREN CURRICULUM TO COUNTER RADICALISM: Study on Pondok Pesantren Wali Songo Ngabar Ponorogo
Authors: Suradi Ahmad , Khoiri Qolbi , Nilawati Nilawati , Gustari Nopian 
Published: July 2021

This study aims to describe the moderate educational views of the Pondok Pesantren Wali Songo community in Ngabar Ponorogo and their efforts to prevent radical ideology. This is a qualitative research and the subject is the main source of data. The informants are the Kyai (the leader) and the Asâtîdh (the teachers) Council in the Pesantren. The results reveals that the Pesantren Wali Songo designed a curriculum that provided a comprehensive understanding of Islamic teachings. For example, the material of fiqh is embedded with uṣûl al-fiqh. In uṣûl al-fiqh, there are rules of istinbâṭ al-ḥukm besides the Quran and hadith such as ijmâ‘, qiyâs, ‘urf, maṣlaḥah al-mursalah, and maqâsid al-sharî‘ah so that fiqh is flexible. In addition, the Pesantren recruited a board of teachers who had moderate understanding and background in kâffah Islamic ideology. Santri (the students) are protected from information access and certain association which lead to radicalism. In developing moderate Islam, the curriculum there require them to study books that explain the understanding of Islam Ahl al-Sunnah wa al-Jamâ‘ah.
Kunci-Kunci Dalam Pengembangan Kreativitas Anak Usia Dini
Authors: Afnita Juli Afnita Uli 
Published: July 2021

Abstrak
Penelitian ini bertujuan untuk menjelaskan dalam pengembangan kreativitas anak usia dini. Tulisan ini mengulas mengenai kunci-kunci pengembangan kreativitas anak usia dini.Metode yang digunakaan penelitian kualitatif. Data yang didapat dari wawancara dan observasi langsung disekolah.Hasil dari penelitian ini menunjukkan bahwa anak usia dini merupakan masa keemasan (Golden Age) yang bagi seorang anak masih memerlukan stimulus sebagai persiapan untuk memasuki jenjang pendidikan selanjutnya. Kreativitas dapat dipupuk dari sejak dini dengan tujuan pengembangan anak lebih berkreasi untuk mengembangkan ide barunya. Orangtua, pendidik maupun orang disekitarnya perlu memaksimalkan dalam pengembangan kreativitas anak disegala hal. Pendidikan anak usia dini terkhusus di sekolahnya, yang melainkan guru harus menjadi pondasi agar dicontohkan oleh anak didik. Dengan demikian, guru yang meningkatkan imajinasi anak dengan mengarahkan serta mengembangkan kreativitasnya. Hal ini, dengan mengembangkan kreativitas dalam melatih anak didik sesuai imajinasi yang dimiliki nya sehingga mendapatkan hasil karya yang memuaskan bagi anak usia dini serta mampu mengoptimalkan segala pengembangan kreativitasnya.

Kata Kunci: Pengembangan, Kreativitas, Anak.
Le transport hippomobile urbain au Sénégal - Situation et importance économique dans la ville de Thiès
Authors: Ly Cheikh , Fall B. , Camara Brahima , Ndiaye C.M. 
Published: July 2021

Cette étude décrit la situation et analyse l'importance économique de la traction hippomobile urbaine et périurbaine au Sénégal, à partir du cas de la ville de Thiès. Cent attelages (64 fiacres et 36 charrettes) ont été choisis au hasard et leurs cochers ont été interrogés. Les données collectées ont concerné les cochers et les chevaux, les caractéristiques et la gestion des attelages et enfin les résultats économiques (coûts, recettes et gains). Pour un travail de six jours par semaine, les fiacres et les charrettes ont généré pour le propriétaire de l'attelage un gain monétaire net quotidien moyen équivalent respectivement à 61% (2 202 francs CFA) et 66% (2 779 FCFA) de leur chiffre d'affaires quotidien respectif (3 600 et 4 200 FCFA). Les charrettes sont apparues légèrement plus rentables car leurs tarifs étaient plus élevés. L'importance économique du cheval est illustrée et des recommandations sont proposées pour améliorer ses performances et sa participation à l'économie nationale.