bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplicación del proceso de análisis jerárquico para la evaluación del riesgo de incendio en la industria colombiana
Authors: Uribe-Botero Julian , Londoño-Ciro Libardo Antonio 
Published: June 2021

La gestión de las emergencias hace parte fundamental de la seguridad y salud en el trabajo. Los incendios se constituyen como las emergencias más comunes en las industrias de nuestro país y en todo el mundo. Por medio del proceso de análisis multi atributo, específicamente el proceso de análisis jerárquico (AHP), los factores de riesgo fueron identificados en las investigaciones que se han realizado usando este método de análisis. El nivel de importancia de cada factor fue calculado por medio de un grupo de expertos que aplicaron el proceso de análisis jerárquico. Los resultados de la investigación pueden ser usados para tener una evaluación detallada el riesgo de incendio que permitiría a los inversionistas o propietarios tomar medidas para reducir las posibles pérdidas en caso de incendio; a las compañías de seguro realizar incrementos en las primas de riesgo basados en la evacuación del riesgo; a los departamentos de bomberos el nivel de cumplimiento de los requerimientos normativos.
Emergency management is a fundamental part of occupational safety and health. Fires are the most common emergencies in the industries of our country and throughout the world. Applying the multi-criteria analysis method, the investigations using the analytic hierarchy process (AHP) in fire risk assessment allowed the identification of fire risk factor. An experts group was consulted about the level of importance of fire risk factors in the fire risk evaluation, for these purpose each expert used the AHP. Results of research can be use to perform the detailed assessment of fire risk, allowing state owners and investors to carry out actions for reduce possible losses in case of fire. Insurance companies can perform the detailed assessment of fire risks on the object and to calculate a risk extra charge to an insurance premium. Fire departments can determine the compliance of a condition of object with requirements of regulations
Fabricación de crisoles con caolinita de Combita - Boyacá para la caracterización de minerales de oro
Authors: Jiménez-Tovar Ginna Alejandra , García-Tocarruncho Sandra M. , Parra-Pinilla Mario 
Published: June 2021

La región boyacense cuenta con grandes riquezas minerales y una de ellas es la roca sedimentaria de arcilla caolinitica, con excelentes propiedades para la industria cerámica tradicional. Al realizar pruebas de caracterización a este material se encontró en el análisis propiedades plásticas, de alta refractariedad, bajo punto de fusión, resistencia a los choques térmicos y resistencia a la rotura. A partir de estos resultados se crearon crisoles resistentes a altas temperaturas, por diferentes tipos de fabricación, obteniéndose crisoles aptos para utilizarlos en ensayos de fusión a temperaturas de 1200°C.
The Boyacá region has great mineral wealth and one of them is the sedimentary rock of kaolinitic clay, with excellent properties for the traditional ceramic industry. When performing characterization tests on this material, its plastic properties, high refractoriness, low melting point, resistance to thermal shocks and resistance to breakage were defined. These properties are due to its kaolinitic composition, aluminum silicate and the presence of magnesium in the clay. From these results, crucibles resistant to high temperatures were created by different types of manufacture, suitable for use in fusion tests at temperatures of 1200 ° C, and especially in fire tests for the characterization of gold ore.
HUBUNGAN PENGETAHUAN DAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) TERHADAP KEJADIAN SAKIT PADA ANAK USIA SEKOLAH DI KABUPATEN BANYUMAS
Authors: RUBAI WINDRI LESMANA , HAPSARI PRAMESTHI WIDYA , SURIJATI KATRI ANDINI 
Published: June 2021

ABSTRAKMunculnya berbagai penyakit yang sering menyerang anak usia sekolah, umumnya berkaitan dengan pemahaman anak tentang apa itu hidup bersih dan sehat, serta penerapan perilaku hidup bersih dan sehatan (PHBS) dan pemahaman anak tentang apa itu hidup bersih dan sehat. Penelitian ini bertujuan untuk melihat hubungan antara pengetahuan dan PHBS anak sekolah dasar terhadap kejadian sakit yang di alami di masa pandemi Covid-19 ini. Pendekatan kuantitatif dengan rancangan studi potong lintang dilakukan dengan melibatkan 58 anak sekolah dasar yang berada di wilayah perkotaan dan pedesaan Kabupaten Banyumas. Hasil penelitian menunjukkan, sebagian besar siswa memiliki pengetahuan tentang gizi dan kesehatan yang masih rendah (62,1%), meski demikian, siswa yang menerapkan PHBS dengan baik sudah lebih banyak (63,8%). Uji chi-square antara pengetahuan siswa dengan kejadian sakit diperoleh nilai p=0.051, dan antara penerapan PHBS siswa dengan kejadian sakit nilai p = 0.478. Dapat disimpulkan bahwa tidak ada hubungan yang signifikan antara pengetahuan dan PHBS terhadap kejadian sakit anak sekolah dasar di wilayah perkotaan dan pedesaan Kabupaten Banyumas.Kata kunci: Anak Sekolah Dasar, Perilaku Hidup Bersih dan Sehat, Pedesaan. ABSTRACTVarious diseases that often attack school-age children, are generally related to children's understanding of what is clean and healthy living, as well as the application of clean and healthy living habits (PHBS) and children's understanding of what is clean and healthy living. This study aims to see the relationship between knowledge and PHBS of elementary school children on the incidence of illness during the pancemic of Covid-19. A quantitative approach with a cross-sectional study design was carried out involving 58 elementary school children in urban and rural areas of Banyumas Regency. The results showed that most students had low knowledge of nutrition and health (62.1%), however, there were already more students who had implemented PHBS properly (63.8%). Chi-square test between students 'knowledge and the incidence of illness obtained p value = 0.051, and between the application of students' PHBS and the incidence of illness p = 0.478. It can be concluded that there is no significant relationship between knowledge and PHBS on the incidence of illness in primary school children in urban and rural areas of Banyumas Regency. Keywords: School-age children, Cleand and Healthy Living Habits (PHBS), urban, rural area.
Literatur review: Implementasi Marketing Mix 7P Terhadap Tingkat Kepuasan Pasien Di Rumah Sakit
Authors: Marpaung Desi Natalia , Ernawaty Ernawaty - , Prayoga Diansanto - , Lailiyah Syifa’ul - 
Published: June 2021

The marketing mix is a marketing strategy used by hospitals to maximize service delivery to patients. The purpose of study was to analyze the effect of the 7P marketing mix (product, price, place, promotion, process, people, physical building) on patient satisfaction in the hospital. The method of writing literature review begins with selecting topics, determining keywords to find journal references. The databases used include Google Scholar, Elsevier, Portal Garuda, Shinta. Reference searches are limited from 2016 to 2020. The keywords used are "Marketing mix, 7p Marketing mix, Hospital, Patient Satisfaction". This study sought a reference list of studies, which included 85 studies taken from the search. A total of 25 articles in cleaning and there are 7 articles included in the discussion. Selection of journals selected based on inclusion criteria. The inclusion criteria in this research is an analysis of the effect of 7P Marketing Mix on Patient Satisfaction in the Hospital. Of the 7 studies reviewed, one study explained that the 7P marketing mix had a significant effect on patient satisfaction as evidenced by statistical tests with p value = 0.00 <? = 0.05. Through 7P marketing optimization in the hospital, it will have a positive impact on increasing patient satisfaction Keywords : Hospital, Marketing Mix, Marketing Mix 7P, Patient Satisfaction
THE CORRELATION THE ROLE OF SUPERVISOR TAKING MEDICINE WITH THE SUCCESS OF TREATMENT OF LUNG TB IN PUBLIC HEALTH CENTER GERAK MAKMUR SAMPOLAWA, SOUTH BUTON
Authors: Taswin Taswin , Izan Izan - , Wahyuddin Wahyuddin - , Dahmar Dahmar , Dahmar Dahmar 
Published: June 2021

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterum Tuberculosis which can spread through droplets that have been infected with TB bacilli. In 2018, there was increasing case of lung TB about 33 people (4 people is broken up treatmment and failed, 29 is healed). The purpose of this study was to determine the relationship between the assistance of taking medication with the success of the treatment of pulmonary TB patients and the relationship of mentoring for repeat treatment at the puskesmas with the success of the treatment of pulmonary TB patients at Gerak Makmur Puskesmas, Sampolawa Subdistrict, South Buton District. This type of research is quantitative research using cross sectional design. The number of samples in this study were 33 people. Sampling in this study uses total sampling, which is the sample taken entirely from the population who finished treatment at the prosperous Gerak Community Health Center. Data analysis performed was univariate and bivariate analysis with chi square test. The results showed that there was a relationship between the role of the supervisor of taking drugs with the success of pulmonary TB treatment in the working area of Gerak Makmur Selatan Buton South Puskesmas with a value (p = 0,000<0,05) and there is a relationship between medical assistance and the success of pulmonary TB treatment in the working area of Gerak Makmur Selatan Buton Puskesmas with a value (p = 0.008<0,05). shows that there is a relationship between the role of the supervisor of taking drugs with the success of pulmonary TB treatment and there is a relationship between the assistance of taking drugs with the success of pulmonary TB treatment, and there is a relationship between mentoring repeat treatment with the success of pulmonary TB treatment at Gerak Makmur Selatan Buton Selatan health center.Keywoard: pulmonary TB successful treatment, supervision of taking medication
RETRACTED: Amorphous Selenium Nanoparticles Improve Vascular Function in Rats With Chronic Isocarbophos Poisoning via Inhibiting the Apoptosis of Vascular Endothelial Cells
Authors: Zhu Moli , Gao Zhitao , Fu Yutian , Qiu Yue , Huang Keke , Zhu Chaonan , Wu Yinan , Zhu Tiantian , Wang Qianqian , Yang Lin , Yin Yaling , Li Peng 
Published: June 2021

AimThis study aimed to investigate the preventive effect and possible mechanism of amorphous selenium nanoparticles (A-SeQDs) on isocarbophos induced vascular dysfunction.MethodsA-SeQDs was made by auto redox decomposition of selenosulfate precursor. Male rats were given isocarbophos (0.5 mg/kg/2 days) by intragastric administration for 16 weeks to induce vascular dysfunction. During the course, A-SeQDs (50 mg/kg/day) was added to the water from week 5. Then, the rats were killed to observe and test the influence of A-SeQDs on the vascular dysfunction induced by isocarbophos. Finally, human umbilical vein endothelial cells (HUVECs) were treated with 10% DMEM of isocarbophos (100 μM) for 5 days to detect the related indexes. Before the use of isocarbophos treatment, different drugs were given.ResultsA-SeQDs could reduce total carbon dioxide, MDA, VCAM-1, ICAM-1, IL-1, and IL-6 while increasing oxygen saturation, NO content, and SOD activity in rats. A-SeQDs also resulted in relatively normal vascular morphology, and the expression of sodium hydrogen exchanger 1 (NHE1) and caspase-3 decreased in rats. Furthermore, in HUVECs treated with isocarbophos, A-SeQDs maintained mitochondrial membrane potential, inhibited the cleaved caspase-3 expression, and released cytochrome c from mitochondria to cytosol.ConclusionA-SeQDs can inhibit the apoptosis of HUVECs through the mitochondrial pathway, and effectively treat the impairment of vascular endothelial function caused by isocarbophos, which is NHE1-dependent.
Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi
Authors: Ming Wenzhuo , Zhang Yi , Sun Yiwei , Bi Guangming , Su Jing , Shao Zhutao , Meng Dali 
Published: June 2021

Four new guaiane-type sesquiterpenes, argyin H–K (1–4), and two known analogues (5 and 6) were isolated from the leaves of Artemisia argyi Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (1H NMR, 13C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of A. argyi, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested in vitro using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC50 values of 15.13–18.63 μM, which were superior to that of oxaliplatin (i.e., IC50 22.20 μM).
Polymorphism of Antifolate Drug Resistance in Plasmodium vivax From Local Residents and Migrant Workers Returned From the China-Myanmar Border
Authors: Zeng Weilin , Wang Siqi , Feng Shi , Zhong Daibin , Hu Yue , Bai Yao , Ruan Yonghua , Si Yu , Zhao Hui , Yang Qi , Li Xinxin , Chen Xi , Zhang Yanmei , Li Cuiying , Xiang Zheng , Wu Yanrui , Chen Fang , Su Pincan , Rosenthal Benjamin M. , Yang Zhaoqing 
Published: June 2021

Drug-resistant Plasmodium vivax malaria impedes efforts to control, eliminate, and ultimately eradicate malaria in Southeast Asia. P. vivax resistance to antifolate drugs derives from point mutations in specific parasite genes, including the dihydropteroate synthase (pvdhps), dihydrofolate reductase (pvdhfr), and GTP cyclohydrolase I (pvgch1) genes. This study aims to investigate the prevalence and spread of drug resistance markers in P. vivax populating the China-Myanmar border. Blood samples were collected from symptomatic patients with acute P. vivax infection. Samples with single-clone P. vivax infections were sequenced for pvdhps and pvdhfr genes and genotyped for 6 flanking microsatellite markers. Copy number variation in the pvgch1 gene was also examined. Polymorphisms were observed in six different codons of the pvdhps gene (382, 383, 512, 549, 553, and 571) and six different codons of the pvdhfr gene (13, 57, 58, 61, 99, 117) in two study sites. The quadruple mutant haplotypes 57I/L/58R/61M/117T of pvdhfr gene were the most common (comprising 76% of cases in Myitsone and 43.7% of case in Laiza). The double mutant haplotype 383G/553G of pvdhps gene was also prevalent at each site (40.8% and 31%). Microsatellites flanking the pvdhfr gene differentiated clinical samples from wild type and quadruple mutant genotypes (FST= 0.259-0.3036), as would be expected for a locus undergoing positive selection. The lack of copy number variation of pvgch1 suggests that SP-resistant P. vivax may harbor alternative mechanisms to secure sufficient folate.
Real-World Outcomes of Revascularization Strategies in Patients With Left Ventricular Dysfunction and Three-Vessel Coronary Disease Stratified by Mitral Regurgitation
Authors: Fan Qin , Liu Jun , Xu Yan , Ni Ruiqing , Xi Rui , Wang Fang , Hu Jian , Sun Hongyue , Yang Zhenkun , Zhou Mi , Zhang Ruiyan , Zhao Qiang , Tao Rong 
Published: June 2021

Aims: Limited information exists regarding optimal revascularization options for patients with triple-vessel coronary artery disease (TVD), heart failure (HF), and different degrees of mitral regurgitation (MR). Thus, we aimed to compare the effect of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) surgery in the indicated patients.Methods and Results: In the real-world prospective study, 1190 patients with multi-vessel disease and decreased left ventricular systolic function but without severe MR, who underwent PCI or CABG, were enrolled and followed-up for 4.7 ± 1.8 years. The primary endpoint was a composite of cardiovascular death and HF hospitalization. Secondary endpoints were the individual components of the primary outcome. Risk of the primary endpoint was higher in the PCI than in the CABG group (HR = 1.38, 95%CI: 1.14–1.67, and P &lt; 0.01), particularly in patients with moderate MR (HR = 1.85, 95%CI: 1.35–2.55, and P &lt; 0.01). In patients with no-mild MR, the risk of the primary endpoint did not differ significantly between PCI and CABG (P = 0.09). Treatment with PCI was associated with an increased risk for cardiovascular death and HF hospitalization in the moderate MR cohort, while PCI was comparable to CABG in the no-mild MR cohort.Conclusions: In this real-world study, for patients with HF and TVD, CABG was related to lower adverse outcome rates compared to PCI. Assessment of MR can aid in selecting optimal revascularization therapies and in risk stratification.
Quantitative Assessment of Left and Right Atrial Strains Using Cardiovascular Magnetic Resonance Based Tissue Tracking
Authors: Qu Yang-Yang , Buckert Dominik , Ma Gen-Shan , Rasche Volker 
Published: June 2021

Background: Left and right atrium (LA and RA) exert an essential and dynamic role in ventricular filling and hence affect heart performance. Strain quantification has been reported as a novel parameter to assess function. However, the assessment of bi-atrial strains with cardiovascular magnetic resonance (CMR) based techniques is still limited and gender- and age-specific normal values in a healthy population are missing.Methods: One hundred and fifty healthy volunteers (49.8 ± 17.3 years, 75 males) undergoing 1.5 Tesla CMR examination were retrospectively and consecutively recruited. LA and RA free wall (RAFW) radial and longitudinal strains (RS and LS) associated with atrial reservoir, conduit and booster pump functions were evaluated with CMR based tissue tracking (CMR-TT) technique.Results: The reservoir, conduit and pump LS resulted as 30.7 ± 10.2%, 19.5 ± 8.2%, 10.9 ± 3.7% for LA, and 52.2 ± 17.6%, 33.3 ± 14.2%, 19.1 ± 8.5% for RAFW, respectively. The amplitude of RA strains was significantly larger than that of LA strains, except for conduit RS. With the increase of age, the decrement of majority of reservoir and conduit strains were observed, while pump strains remained unaffected. Females presented with significantly larger RAFW strains compared with males, especially in the elderly. In addition to the positive correlation between atrial strains and emptying fraction, the negative correlation between atrial strains and volume index was also confirmed. Intra-observer reproducibility of LA strains was superior to RAFW strains (coefficient of variation: 10.12–17.04% vs. 10.80–27.36%, respectively), and the measurement of reservoir and conduit strains was more reproducible in comparison with pump strain.Conclusion: CMR-TT is a feasible and reproducible technique to quantify LA and RA strains and determine atrial phasic functions. The existence of age- and gender-related difference of strains suggests the necessity to establish specific normal values for individual populations.
Cleaner Energy Storage: Cradle-to-Gate Life Cycle Assessment of Aluminum-Ion Batteries With an Aqueous Electrolyte
Authors: Melzack N , Wills RGA , Cruden A 
Published: June 2021

In the context of growing demand on energy storage, exploring the holistic sustainability of technologies is key to future-proofing our development. In this article, a cradle-to-gate life cycle assessment of aqueous electrolyte aluminum-ion (Al-ion) batteries has been performed. Due to their reported characteristics of high power (circa 300 W kg−1 active material) and low energy density (circa 15 Wh kg−1 active material), these results were compared with those of supercapacitors (per kW). Initial findings suggest these aluminum-ion cells have fewer environmental impacts than commercial supercapacitors, hence offering a more environmentally sensitive energy storage technology solution. Al-ion batteries are in their early development, and this result shows a strong argument for continuing research into this technology alongside other emerging energy storage systems.
A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm
Authors: Rehan Mohd , Ahmed Firoz , Howladar Saad M. , Refai Mohammed Y. , Baeissa Hanadi M. , Zughaibi Torki A. , Kedwa Khalid Mohammed , Jamal Mohammad Sarwar 
Published: June 2021

BackgroundThe newly identified betacoronavirus SARS-CoV-2 is the causative pathogen of the coronavirus disease of 2019 (COVID-19) that killed more than 3.5 million people till now. The cytokine storm induced in severe COVID-19 patients causes hyper-inflammation, is the primary reason for respiratory and multi-organ failure and fatality. This work uses a rational computational strategy to identify the existing drug molecules to target host pathways to reduce the cytokine storm.ResultsWe used a “host response signature network” consist of 36 genes induced by SARS-CoV-2 infection and associated with cytokine storm. In order to attenuate the cytokine storm, potential drug molecules were searched against “host response signature network”. Our study identified that drug molecule andrographolide, naturally present in a medicinal plant Andrographis paniculata, has the potential to bind with crucial proteins to block the TNF-induced NFkB1 signaling pathway responsible for cytokine storm in COVID-19 patients. The molecular docking method showed the binding of andrographolide with TNF and covalent binding with NFkB1 proteins of the TNF signaling pathway.ConclusionWe used a rational computational approach to repurpose existing drugs targeting host immunomodulating pathways. Our study suggests that andrographolide could bind with TNF and NFkB1 proteins, block TNF-induced cytokine storm in COVID-19 patients, and warrant further experimental validation.