bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid‐face reshaping using threads with bidirectional convergent barbs: A retrospective study
Authors: Santorelli Adriano , Cerullo Fabio , Cirillo Pierfrancesco , Cavallini Maurizio , Avvedimento Stefano 
Published: February 2021

AbstractBackgroundMinimally invasive procedures, such as thread suspension techniques, are a growing trend for facial rejuvenation. However, not enough data are available on the efficacy, outcomes, and morbidity of suture suspension techniques in mid‐face reshaping.AimsOur goal was to assess treatment outcomes and patient satisfaction following mid‐face reshaping using threads with bidirectional convergent barbs (DefinisseTM free floating threads).Patients/MethodsWe performed a retrospective analysis of 60 patients who underwent treatment for mid‐face reshaping using DefinisseTM free floating threads. Response to treatment was assessed at 6 months using the mid‐face‐specific Mid‐Face Volume Deficit scale (Allergan®), Global Aesthetic Improvement and FACE‐QTM scales.ResultsSixty patients underwent mid‐face treatment with the suspension thread technique (mean age 51.3, 90% female). No concomitant procedures were done. A reduction by one point or more in the Mid‐Face Volume Deficit Scale (MDFVS) score treatment was seen in all patients after 6 months. Mean overall MFVDS and FACE‐QTM scores were significantly improved. On the GAIS, most patients were rated as improved or better both by the evaluating investigators and during self‐assessment. No major complications were observed, and none of the patients requested the removal of the threads (mean follow‐up 9.8 months, range 6–14 months).ConclusionOur results suggest that mid‐face reshaping with DefinisseTM free floating threads is a safe and reliable procedure characterized by low complication rates and good esthetic results. This minimally invasive procedure is a good alternative for normal or combination skin patients who refuse or want to delay the need for traditional rhytidectomy.
Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis
Authors: Isola Gaetano , Polizzi Alessandro , Alibrandi Angela , Williams Ray C. , Lo Giudice Antonino 
Published: February 2021

AbstractBackground and ObjectiveDifferent evidence has shown that Galectins have a key role as modulators of cell surface functions and signaling in a wide range of inflammatory diseases during their preclinical stages. The aim of this study was to analyze the association and impact of periodontitis and coronary heart disease (CHD) on salivary and serum Galectin‐3 in patients with periodontitis and CHD.Materials and MethodsFor the present study, healthy controls (n = 38), periodontitis (n = 40), CHD (n = 39), and a combination of periodontitis +CHD (n = 38) patients were enrolled and analyzed. In each patient, demographic characteristics and a full‐mouth clinical periodontal examination were achieved. Moreover, serum and salivary samples were collected to assess Galectin‐3 and Endothelin‐1 (ET‐1) levels. The Jonckheere‐Terpstra p‐trend and Spearman's correlation tests as well as uni‐ and linear regression analyses were used to analyze the study data.ResultsPatients with periodontitis (serum, p = .003; saliva, p < .001) and periodontitis + CHD groups (serum p = .004; saliva, p < .001) had higher median serum and salivary concentrations of Galectin‐3 in comparison with CHD and healthy controls. Serum (p = .006) and salivary (p = .009) Galectin‐3 levels were significantly correlated with serum ET‐1. The multivariate regression analysis highlighted that periodontitis (p = .047) was the significant predictor of serum Galectin‐3 levels while ET‐1 (p = .028) was the significant predictor of salivary Galectin‐3 levels.ConclusionThe results showed that patients with periodontitis and periodontitis + CHD presented significant higher serum and salivary Galectin‐3 levels in comparison with CHD patients and healthy subjects. Periodontitis and ET‐1 were the significant predictors of serum and salivary Galectin‐3 levels, respectively.
Association among periodontitis severity, anti‐agalactosyl immunoglobulin G titer, and the disease activity of rheumatoid arthritis
Authors: Kaneko Chihiro , Kobayashi Tetsuo , Ito Satoshi , Sugita Noriko , Murasawa Akira , Ishikawa Hajime , Tabeta Koichi 
Published: February 2021

AbstractObjectiveThe aim of the present study was to evaluate the association between the periodontal and serological parameters and the disease activity of rheumatoid arthritis (RA) and between the anti‐agalactosyl immunoglobulin G (IgG) titer and periodontitis severity. The objective was also to assess the effect of supragingival scaling on the serological parameters in patients with RA.BackgroundThe periodontal and serological parameters in relation to the autoimmune inflammatory response have been linked to RA disease activity. However, the association of the anti‐agalactosyl IgG titer with RA disease activity and periodontitis severity has not been elucidated.MethodsThe periodontal, rheumatologic, and serological data were collected from 127 patients with RA in a retrospective cohort study. Of the 127 patients, 21 had been randomly assigned to receive oral hygiene instruction and supragingival scaling. The anti‐agalactosyl IgG titer was determined by an electrochemiluminescence immunoassay.ResultsThe patients with a moderate to high RA disease activity showed significantly higher levels of probing depth (PD), clinical attachment level, anti‐cyclic citrullinated peptide IgG, and anti‐agalactosyl IgG titer and greater mean percentages of severe periodontitis than those with a low RA disease activity (p < .05 for all). Both univariate and multivariate analyses revealed a significantly positive correlation between the PD and RA disease activity (p = .009 and p = .001), between the anti‐agalactosyl IgG titer and RA disease activity (p = .002 and p < .001), and between the anti‐agalactosyl IgG titer and PD (p < .001 for both). Supragingival scaling significantly decreased the anti‐agalactosyl IgG titer (p = 0.03).ConclusionThe PD and anti‐agalactosyl IgG titer are positively interrelated, both of which are correlated positively with RA disease activity and influenced by supragingival scaling in patients with RA.
Isolated bacterial infection without decompensation has no impact on survival of compensated patients with cirrhosis
Authors: Reichert Matthias C. , Schneider Christina , Greinert Robin , Casper Markus , Grünhage Frank , Wienke Andreas , Zipprich Alexander , Lammert Frank , Ripoll Cristina 
Published: February 2021

AbstractBackground & AimsBacterial infections (BI) affect the natural course of cirrhosis and were suggested to be a landmark event marking the transition to the decompensated stage. Our specific aim was to evaluate the impact of BI on the natural history of compensated cirrhosis.MethodsWe analyzed 858 patients with cirrhosis, evaluated for the INCA trial (EudraCT 2013‐001626‐26) in 2 academic medical centers between February 2014 and May 2019. Only patients with previously compensated disease were included. They were divided into 4 groups: compensated without BI, compensated with BI, 1st decompensation without BI, and 1st decompensation with BI.Results425 patients (median 61 [53‐69] years) were included in the final prospective analysis. At baseline, 257 patients were compensated (12 [4.7%] with BI), whereas 168 patients presented with their 1st decompensation (42 [25.0%] with BI). In patients who remained compensated MELD scores were similar in those with and without BI. Patients with their first decompensation and BI had higher MELD scores than those without BI. Amongst patients who remained compensated, BI had no influence on transplant‐free survival, whereas patients with their 1st decompensation and concurrent BI had significantly reduced transplant‐free survival as compared with those without BI. The development of BI or decompensation during follow‐up had a greater impact on survival than each of these complications at baseline.ConclusionsIn compensated patients with cirrhosis, the 1st decompensation associated to BI has worse survival than decompensation without BI. By contrast, BI without decompensation does not negatively impact survival of patients with compensated cirrhosis.
Epidemiological projections of viral‐induced hepatocellular carcinoma in the perspective of WHO global hepatitis elimination
Authors: Vo Quang Erwan , Shimakawa Yusuke , Nahon Pierre 
Published: February 2021

AbstractHepatitis B is an eminent risk factor for hepatocellular carcinoma (HCC) in Southeast Asia and sub‐Saharan Africa, whereas hepatitis C is a key risk factor for HCC in Western Europe and North America. Increased awareness of the global burden of viral hepatitis resulted, in May 2016, in the adoption of the first global health sector strategy on viral hepatitis by the World Health Assembly, which calls for the elimination of viral hepatitis as a public health threat by 2030. Although the incidence of liver cancer resulting from viral infections has increased since the 1990s, the implementation of public health interventions, such as hepatitis B vaccination and antiviral therapies might have reduced the global burdens of HCC. Hepatitis B immunization in infancy has been associated with a reduction in the risk of infant fulminant hepatitis, chronic liver disease, and HCC in Taiwan. Achieving viral hepatitis elimination by 2030 can be accelerated by improving the access to HCC screening programs. HCC surveillance programs in developed countries must be refined to increase an access to personalized surveillance program, whereas the limited access to surveillance and treatment of HCC in developing countries remains a significant public health issue.
Sarcopenia in nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality in the United States
Authors: Kim Donghee , Wijarnpreecha Karn , Sandhu Keeryth K. , Cholankeril George , Ahmed Aijaz 
Published: February 2021

AbstractBackground & AimsNonalcoholic fatty liver disease (NAFLD) has been associated with sarcopenia. However, mortality in the setting of NAFLD‐related sarcopenia remains undefined. We aim to determine the all‐cause and cause‐specific mortality from sarcopenia among adults with NAFLD in the USA.Methods11 065 individuals in the Third National Health and Nutrition Examination Survey were studied and linked mortality through 2015 was analysed. NAFLD was diagnosed based on presence of ultrasonographic hepatic steatosis without other known liver diseases. Sarcopenia was defined as skeletal muscle index determined by bioelectrical impedance analysis. The Cox proportional hazard model was used to assess all‐cause mortality and cause‐specific mortality, and hazard ratio (HR) adjusted for known risk factors.ResultsDuring a median follow‐up of 23 years or more, sarcopenia was associated with increased all‐cause mortality (HR 1.27, 95% confidence interval [CI] 1.11‐1.44). Only in individuals with NAFLD, sarcopenia was associated with a higher risk for all‐cause mortality, while this association was absent in those without NAFLD. Individuals with both sarcopenia and NAFLD had a higher risk for all‐cause mortality (HR 1.28 95% CI 1.06‐1.55) compared with those without sarcopenia and NAFLD. Furthermore, sarcopenia was associated with a higher risk for cancer‐ and diabetes‐related mortality among those with NAFLD. This association was not noted in those without NAFLD.ConclusionIn this nationally representative sample of US adults, sarcopenia was associated with a higher risk for all‐cause, cancer‐ and diabetes‐related mortality in individuals with NAFLD.
Analysis of the transcriptomic, metabolomic, and gene regulatory responses to Puccinia sorghi in maize
Authors: Kim Saet‐Byul , Van den Broeck Lisa , Karre Shailesh , Choi Hoseong , Christensen Shawn A. , Wang Guan‐Feng , Jo Yeonhwa , Cho Won Kyong , Balint‐Kurti Peter 
Published: February 2021

AbstractCommon rust, caused by Puccinia sorghi, is a widespread and destructive disease of maize. The Rp1‐D gene confers resistance to the P. sorghi IN2 isolate, mediating a hypersensitive cell death response (HR). To identify differentially expressed genes (DEGs) and metabolites associated with the compatible (susceptible) interaction and with Rp1‐D‐mediated resistance in maize, we performed transcriptomics and targeted metabolome analyses of P. sorghi IN2‐infected leaves from the near‐isogenic lines H95 and H95:Rp1‐D, which differed for the presence of Rp1‐D. We observed up‐regulation of genes involved in the defence response and secondary metabolism, including the phenylpropanoid, flavonoid, and terpenoid pathways. Metabolome analyses confirmed that intermediates from several transcriptionally up‐regulated pathways accumulated during the defence response. We identified a common response in H95:Rp1‐D and H95 with an additional H95:Rp1‐D‐specific resistance response observed at early time points at both transcriptional and metabolic levels. To better understand the mechanisms underlying Rp1‐D‐mediated resistance, we inferred gene regulatory networks occurring in response to P. sorghi infection. A number of transcription factors including WRKY53, BHLH124, NKD1, BZIP84, and MYB100 were identified as potentially important signalling hubs in the resistance‐specific response. Overall, this study provides a novel and multifaceted understanding of the maize susceptible and resistance‐specific responses to P. sorghi.
The Absence of Divine Ideas in theSumma Contra Gentiles
Authors: Vater Carl A. 
Published: February 2021

AbstractIn the 20thcentury, some prominent Thomists questioned whether St. Thomas Aquinas is really committed to a theory of divine ideas. There is no doubt that Aquinas articulates such a theory in hisSentences Commentary,Disputed Questions on Truth, andSumma theologiae. Still, he seems to omit an account of divine ideas in theSumma Contra Gentiles. If St. Thomas thinks divine ideas are necessary for understanding God's knowledge, why would he skip discussing them in thisex professowork? This paper will argue two points. First, St. Thomas does articulate a theory of divine ideas in theSumma Contra Gentiles, even though he changes his terminology. His account of divine reasons (rationes) is equivalent to a theory of divine ideas. Second, Aquinas changes his vocabulary because of the more apologetic aim of the work. Use of the term ‘ideas’ would be less effective in dialogue with his Muslim and pagan interlocutors.
Gianotti‐crosti syndrome in the setting of recent coronavirus disease‐19 infection
Authors: Swali Ritu N. , Lee Erica B. , Adams Jennifer L. 
Published: February 2021

AbstractSince the onset of the COVID‐19 pandemic, the growing body of literature has largely focused on the adult population. Reported symptoms among children appear to be consistent with those in adults, including fever, respiratory symptoms, and gastrointestinal symptoms, though children may experience an overall milder disease course. Viral exanthems with possible association to COVID‐19 have been reported in pediatric patients. We describe a 10‐month‐old boy with Gianotti‐Crosti syndrome in the setting of recent SARS‐CoV‐2 RT‐PCR positive testing to increase physician awareness and add to the collection of cutaneous manifestations of COVID‐19.
Comparative Public Administration in a Globalized World: Moving Beyond Standard Assumptions Toward Increased Understanding
Authors: van der Wal Zeger , van den Berg Caspar , Haque M. Shamsul 
Published: February 2021

AbstractToday's globalized world calls for a deeper understanding of how and why administrative practices differ across regions and what that means for theory and practice. However, empirical comparative studies in public administration incorporating local and regional particularities in their design, constructs, and interpretation of results are scarce, with the exception of studies on specific constructs such as public service motivation, professional values, and emerging approaches to non‐Western public administration. Consistently, scholars engaged in comparative studies highlight theoretical, methodological, and empirical difficulties in comparing public agencies, employees, and practices as the research instruments and assumptions used often originate from Western countries. Thus, there is a serious need today for adopting more context‐sensitive and balanced approaches to advance our scholarly understanding of systems and practices in different regions. This symposium aims to advance comparative public administration by bringing together novel empirical comparative contributions from scholars from different parts of the world.
CMV presenting as a skin growth in renal transplant patient
Authors: Bhandari Gaurav , Tiwari Vaibhav , Gupta Anurag , Jain Sunila , Gupta Pallav , Bhargava Vinant , Malik Manish , Gupta Ashwani , Bhalla Anil Kumar , Rana Devender Singh 
Published: February 2021

AbstractCMV infection is one of the most common opportunistic infection in kidney transplant patients. If not treated, it is associated with increased mortality and graft loss. It can present as viremia or CMV disease in the form of CMV syndrome or tissue invasive CMV disease. The cutaneous presentation of CMV disease is a rare finding. Its identification is vital as cutaneous CMV infection can signal systemic infection and poor prognosis. In our case, 46‐year‐old male who was a post renal allograft recipient (RAR) presented as a protuberant growth over the medial side of the left ankle. On skin biopsy, nucleomegaly and inclusion bodies were seen in the epithelial cells. Immunohistochemistry was positive for CMV infection. Patient was treated with Ganciclovir, however, he succumbed to death because of severe sepsis due to secondary bacterial infection. Thus, CMV disease should always be kept in mind in immunocompromised patients like post RAR patients who present with cutaneous features like ulcerative lesions or fungating growth.
PREPARATION OF SPRAY DRIED COAMORPHOUS SOLIDS TO IMPROVE THE SOLUBILITY AND DISSOLUTION RATE OF ATORVASTATIN CALCIUM
Authors: Wicaksono Yudi , Rosidi Viddy Agustian , Saragih Sri Yessika , Fauziah Lyta Septi , Setyawan Dwi 
Published: February 2021

Atorvastatin calcium (AC) is a statin drug used to lower cholesterol. Its crystalline form is usually found in the market with low solubility properties. The amorphization of crystalline AC is a technique used to increase its solubility however; the amorphous form has less thermodynamic stability. Therefore, to increase the solubility properties of its crystalline form, an AC coamorphous solid was prepared. This coamorphous solid was prepared using spray drying techniques, and coformers such as isonicotinamide (INA) and maleic acid (MA). Furthermore, characterization was carried out using powder X-ray diffraction, differential scanning calorimetry, fourier transform infrared spectroscopy, and scanning electron microscopy, while the solubility properties test was conducted using the shake-flask and paddle method. The results showed that the spray-dried solids were coamorphous with single-phase homogeneous systems. Furthermore, the coamorphous solids, AC-INA and AC-MA were found to have a higher Tg than the melting points of other components, and formed intermolecular interactions between them. The higher Tg and presence of intermolecular interactions indicate that coamorphous solids are more stable than the amorphous form. Therefore, the results of the solubility and dissolution test showed that the coamorphous solid of AC-INA and AC-MA have better solubility properties compared to the AC crystalline form.
PRODUCTION OF LIPID AND CARBOHYDRATE IN Tetradesmus obliquus UPSI-JRM02 UNDER NITROGEN STRESS CONDITION
Authors: Md Nadzir Syafiqah , Yusof Norjan , Nordin Norazela , Kamari Azlan , Mohd Yusoff Mohd Zulkhairi 
Published: February 2021

Nitrogen stress condition is believed to increase the production of lipid in microalgae, but the synthesis of both lipid and carbohydrate is less known. Therefore, the effect of nitrogen stress condition on the synthesis of lipid and carbohydrate of Tetradesmus obliquus UPSI-JRM02 was studied in a 2 L bioreactor system. The highest lipid and carbohydrate yields achieved under nitrogen stress condition were 37% and 23%, respectively. Nitrogen stress condition induced the accumulation of carbohydrate at early stage but started to reduce on day 4 when the carbon shifted towards lipid production. The fatty acid profile produced under nitrogen stress condition was composed of 54% polyunsaturated fatty acid (PUFA), 43% saturated fatty acid (SFA) and 3% monounsaturated fatty acid (MUFA). The biofuel properties of T. obliquus obtained under the nitrogen stress condition was within the range of biodiesel standard and is most suitable for the usage in cold country.
Diabetic Macular Edema Treatment with Bevacizumab Does Not Depend on the Retinal Nonperfusion Presence
Authors: Sędziak-Marcinek Bogumiła , Teper Sławomir , Chełmecka Elżbieta , Wylęgała Adam , Marcinek Mateusz , Bas Mateusz , Wylęgała Edward 
Published: February 2021

This study evaluated the relationship between the retinal nonperfusion area (NPA) presence and the effectiveness of bevacizumab treatment (IVB) in patients with diabetic macular edema (DME). It also tested the prognostic usefulness of ultra-wide-field fluorescein angiography (UWFFA) and OptosAdvance software for diabetic retinopathy monitoring. Eighty-nine patients with DME with a macular

central

subfield

thickness

CST

≥
250

μ
m

, with (

N
=
49

eyes) and without (

N
=
49

eyes) retinal NPA, underwent nine bevacizumab injections over 12 months. NPA distribution, leakage area distribution, microaneurysm (MA) count, macular CST, diabetic retinopathy severity, and best-corrected visual acuity (BCVA) were assessed. The results show that bevacizumab reduced the macular CST from 420 to 280 μm (

p
<
0.001

) and improved BCVA (

p
<
0.001

) by about 10 ETDRS letters in both groups of patients. Additionally, the therapy reduced total retinal NPA from 29 (14-36) mm2 to 12 (4-18) mm2 (Me (Q1-Q3);

p
<
0.001

) in patients with diagnosed nonperfusion. The effect of the therapy measured with vascular leakage, MA count, BCVArelative, and CSTrelative strongly depended on the zone of the retina and the NPA distribution. We conclude that the bevacizumab treatment had a positive effect on DME and BCVA in both study groups and on the size of retinal NPA in patients with retinal nonperfusion.