bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytoplankton primary production: 14C-in situ and 14C-incubator methods compared
Authors: Larsson Ulf , Nyberg Svante , Walve Jakob 
Published: September 2021

Abstract
We estimated phytoplankton depth-integrated primary production rates at an open sea station in the northern Baltic Proper in 2004–2009 by parallel in situ and ship-board incubations in an “ICES incubator”. Observations were strongly linearly related (r2 = 0.67, p &lt; 0.00001) and produced similar seasonal signals, but incubator estimates were significantly lower in spring (∼5–20%, March–May) and summer (∼30%, June–August), but not in autumn (September–October). Incubator PBmax was significantly lower in all seasons (∼10, 23, and 14% in spring, summer, and autumn), and the initial slope of the PB/E-curve (αB) was two-thirds of in-situ αB in spring and autumn, and half in summer, but not significantly different in autumn, and had an order of magnitude lower standard deviation. Parallel incubations of mixed 0–10 m hose samples at discrete depths in situ and in the incubator gave similar differences in PBmax and αB. This strongly suggests that the main factor causing the lower photosynthesis rates in the incubator was light quality, since all other potential sources of variability were similar. However, we cannot rule out that the lower incubator PBmax was partly due to insufficient light compared to in situ, particularly in summer. Our results suggest that a major challenge to the harmonization of 14C in situ, and artificial light and deck incubator measurements, is to simulate spectral composition changes with depth or, alternatively, use phytoplankton action spectra or constructed action spectra that are less complicated and time-consuming to establish (Kyewalyanga et al., 1997).
Continuity of Singular Kähler–Einstein Potentials
Authors: Guedj Vincent , Guenancia Henri , Zeriahi Ahmed 
Published: September 2021

Abstract
In this note, we investigate some regularity aspects for solutions of degenerate complex Monge–Ampère equations (DCMAE) on singular spaces. First, we study the Dirichlet problem for DCMAE on singular Stein spaces, showing a general continuity result. A consequence of our results is that Kähler–Einstein potentials are continuous at isolated singularities. Next, we establish the global continuity of solutions to DCMAE when the reference class belongs to the real Néron–Severi group. This yields in particular the continuity of Kähler–Einstein potentials on any irreducible Calabi–Yau variety.
The Ethics of Human Challenge Trials Using Emerging Severe Acute Respiratory Syndrome 2 Variants
Authors: Rohrig Abie , Eyal Nir 
Published: September 2021

Abstract
The world’s first coronavirus disease 2019 human challenge trial using the D614G strain of severe acute respiratory syndrome 2 (SARS-CoV-2) is underway in the United Kingdom. The Wellcome Trust is funding challenge stock preparation of the Beta and Delta variant for a follow-up human challenge trial, and researchers at hVIVO are considering conducting these trials. However, little has been written thus far about the ethical justifiability of human challenge trials with SARS-CoV-2 variants of concern. We explore 2 specific characteristics of some variants that may initially be thought to make such trials unethical and conclude that SARS-CoV-2 variant challenge trials can remain ethical.
Knowledge, attitudes and practices of health professionals towards people living with lymphoedema caused by lymphatic filariasis, podoconiosis and leprosy in northern Ethiopia
Authors: Dellar Rachael , Ali Oumer , Kinfe Mersha , Tesfaye Abraham , Fekadu Abebaw , Davey Gail , Semrau Maya , Bremner Stephen 
Published: September 2021

Abstract

Background
Podoconiosis, lymphatic filariasis and leprosy are highly stigmatised neglected tropical diseases that cause lymphoedema. Their enormous impacts on health-related quality of life, mental health and economic productivity can be significantly reduced by morbidity management and disability prevention (MMDP) services, but to deliver such services requires appropriate training of healthcare professionals. The aim of this study was to assess the knowledge, attitudes and practices (KAP) of rural Ethiopian healthcare professionals towards people with lymphoedema as a way to assess training needs.

Methods
This study used questionnaires to quantitatively assess KAP towards people with lymphoedema among rural healthcare professionals in northwest Ethiopia before and 12 months after a short training intervention.

Results
Questionnaires were administered to 14 health professionals at baseline and 21 at follow-up. At baseline, 71% (10/14) were found to hold at least one stigmatising attitude towards lymphoedema patients, compared with 66% (14/21) at follow-up. Large gaps in knowledge were noted, with many unable to identify ways of treating/preventing the diseases.

Conclusions
This study showed high proportions of healthcare workers holding stigmatising views and lacking essential knowledge about lymphoedema. To maximise the impact of MMDP interventions, further research is urgently needed to understand how to address these issues.
Identification of antibiotics triggering the dissemination of antibiotic resistance genes by SXT/R391 elements using a dedicated high-throughput whole-cell biosensor assay
Authors: Guilloteau Hélène , Pradalier Cédric , Roman Véronica L , Bellanger Xavier , Billard Patrick , Merlin Christophe 
Published: September 2021

Abstract

Background
Mobile genetic elements (MGEs) are widely involved in the dissemination of antibiotic resistance genes and some of them, such as the integrative and conjugative element SXT, are even induced by specific antibiotics at sub-lethal concentrations.

Objectives
This work explores collateral effects of a broad range of antibiotics on the mobility of the SXTMO10 element using a specifically designed high-throughput screening test.

Methods
Twenty-five promoters involved in the mobility of SXT and six artificial constitutive promoters were transcriptionally fused to luxCDABE bioluminescent genes and introduced into Escherichia coli strains with or without SXT to build whole-cell biosensors for a large-scale screening involving 48 antibiotics. A bioluminescent assay implementing a classical agar diffusion approach was coupled to an automated data processing pipeline developed to extract and analyse luminescence data from over 2000 antibiotic/biosensor combination profiles.

Results
In addition to quinolones previously reported as inducing the expression of SXT mobility genes, we found that specific antibiotics belonging to other classes, such as imipenem and azithromycin, also behave as inducers. The use of a control set of constitutive biosensors also revealed an unexpected intricate relationship between cell respiration and light production that allowed the identification of antibiotics interfering with the respiration process.

Conclusions
The effect of antibiotics goes beyond the interaction with their primary cell targets and may lead to adverse effects such as triggering the dissemination of resistance by MGEs, sometimes in unpredictable ways. Identifying such MGE-triggering antibiotics is of prime importance for better controlling collateral effects during therapy.
Avoidance Behavior to Guava Leaf Volatile Oil by Three Medically Important Mosquito Vectors
Authors: Jhaiaun Pairpailin , Panthawong Amonrat , Sukkanon Chutipong , Chareonviriyaphap Theeraphap 
Published: September 2021

Abstract
Volatile organic compounds from various plants have received popular interest as one of the vector control tools due to their eco-friendliness and insect-repellent activities. In this study, an excito-repellency assay system was used to examine the noncontact repellency, contact excitation, and knockdown (KD) effects of guava leaf (Psidium guajava L.) oil against Anopheles minimus (Theobald), Anopheles epiroticus (Linton & Harbach), and Culex quinquefasciatus (Say). The organic components of guava oil were identified by gas chromatography–mass spectrometry analysis with dl-limonene (17.4%), cymene (5.49%), and α-terpinene (5.20%) as the major constituents. At concentrations of 2.5 and 5.0%, 100% escape of An. minimus was recorded in the contact assay and 96–98% escape in the noncontact assay. Guava oil stimulated potent irritant (92% escape) and repellent (61–86% escape) effects against Cx. quinquefasciatus. A lower repellency action was observed against An. epiroticus (17–20% escape). No KD effect was observed for guava oil against An. minimus and Cx. quinquefasciatus at any concentration. However, An. epiroticus was more prone to KD effects, with the highest percentage KD (44% in nonescape group) observed with 5.0% guava oil in the noncontact assay. Mortalities of 35% and 11% were observed for An. epiroticus in the nonescape groups in the contact and noncontact assays, respectively. Concentrations of 1.0% and 2.5% guava oil led to &lt;2% mortality in An. minimus. Our findings highlight guava oil as a promising plant-based mosquito repellent that can be included in insecticide formulations for future mosquito control programs.
Real-World Use of Androgen-Deprivation Therapy: Intensification Among Older Canadian Men With de Novo Metastatic Prostate Cancer
Authors: Wallis Christopher J D , Malone Shawn , Cagiannos Ilias , Morgan Scott C , Hamilton Robert J , Basappa Naveen S , Ferrario Cristiano , Gotto Geoffrey T , Fernandes Ricardo , Niazi Tamim , Noonan Krista L , Saad Fred , Hotte Sebastien J , Hew Huong , Chan Katherine F Y , Wyllie Laura Park , Shayegan Bobby 
Published: September 2021

Abstract

Background
Despite the wealth of evidence demonstrating the efficacy of treatment intensification beyond androgen-deprivation therapy (ADT) among patients with de novo metastatic castration-sensitive prostate cancer (mCSPC), little is known of its real-world use. This study examined the real-world uptake of ADT treatment intensification among older men in a large Canadian province.

Methods
We performed a retrospective population-based cohort study using province-wide linked administrative data in Ontario, Canada. Patients 66 years of age and older with de novo mCSPC were included and their treatment with conventional ADT-based regimens, ADT plus next-generation androgen receptor axis–targeted therapy, and ADT plus docetaxel were identified and stratified by time.

Results
From 2014 to 2019, 3556 patients were identified with de novo mCSPC. Most patients (n = 2794 [78.6%]) were treated with a conventional ADT regimen, whereas 399 (11.2%) patients received ADT intensification with docetaxel and 52 (1.5%) patients received abiraterone acetate plus prednisone. In a time-stratified analysis of ADT intensification before and after the pivotal AA+P trial (LATITUDE), AA+P uptake increased from 0.5% to 3.0%, whereas docetaxel use dropped from 12.0% to 10.0%. The median survival of the study population was 18 months (interquartile range = 10-31).

Conclusions
The majority of patients with de novo mCSPC are treated with ADT alone in the Canadian real-world setting, despite randomized clinical trial evidence of benefit with the use of ADT-intensified regimens. As ADT treatment intensification is substantially underused, better understanding of the barriers to treatment and targeted education to address them are needed.
Collusion as Environmental Protection—An Economic Assessment
Authors: Veljanovski Cento 
Published: September 2021

Abstract
This article examines the relationship between the environment, sustainability, and European competition law. It shows that the European Commission’s decisional practice not to exempt anticompetitive agreements under Article 101(3) TFEU is because it selectively prosecutes hardcore cartels. The alleged ‘sustainability gap’ in EU antitrust is, therefore, more apparent than real. It is also shown that the Commission has adopted an efficient enforcement approach given the institutional and budgetary constraints it faces. On the other hand, the Commission’s guidelines on Article 101 TFEU lack coherence and consistency with its overarching Treaty obligations. The pros and cons of expanding Article 101(3) TFEU to take account of the third-party environmental and public policy factors are examined.
Native woody legumes respond more negatively to extreme drought than invasive ones
Authors: Lu Zhengkuan , Zhang Xue , Zhang Hongxiang , Liu Yanjie 
Published: September 2021

AbstractPlant invasion potentially will be affected by increased extreme drought events and deposition of atmospheric N. However, results from previous research indicate that it is not clear as to how extreme drought, N deposition and their interaction affect alien plant invasion, in particular for the invasive woody legumes. We conducted a greenhouse experiment with three invasive and three native woody species of legumes (Fabaceae). We grew plants in extreme drought and in well-watered conditions combined with low and high levels of N and compared plant height, number of leaves and biomass production and allocation. Growth of native woody legumes was suppressed more by extreme drought than that of invasive woody legumes. Although an increase in soil N availability decreased the root mass fraction of plants of all species, it did not affect their overall performance. We found that invasive woody legumes can tolerate the adverse effects of the prolonged extreme drought better than native woody legumes. These results enhance our understanding of the effects of drought due to climate change on the invasion of alien woody legumes.
What do we know about parasitic plants and the leaf economic spectrum?
Authors: Haynes Audrey F 
Published: September 2021

AbstractThe leaf economic spectrum (LES) quantifies correlations between key leaf traits across vascular plants and distills much of the variation in these traits to a single axis. The LES, remarkable in its near universality, has been extensively researched across a variety of contexts. However, parasitic plants relationship to the LES framework remains relatively unexplored. Because the LES is, in part, driven by physiological tradeoffs in the acquisition of carbon (C), in theory heterotrophy in parasitic plants, which supplants some of the essential functions of leaves, could lead to departures from the LES. Using global leaf trait data from the TRY database, this work assessed the overall representation of parasitic plants in the TRY database, then compared the LES suite of leaf traits in parasitic plants to their non-parasitic counterparts. Despite their unique physiology, parasitic plants did not deviate dramatically from the LES, although there were examples of differences in position on the LES and relationships among traits. Perhaps more importantly, parasitic plants are not well represented in the TRY database, making any conclusions here premature.
Childhood Cancer Survivors and Distance Education Challenges: Lessons Learned From the COVID-19 Pandemic
Authors: Carey Lisa B , Ruble Kathy , Paré-Blagoev Juliana , Milla Kimberly , Thornton Clifton P , Henegan Sydney , Jacobson Lisa A 
Published: September 2021

Abstract

Objective
Pediatric cancer survivors have historically struggled to receive adequate educational supports. In Spring 2020, the COVID-19 pandemic forced an emergency switch from traditional in-person education models to distance education, but little information is available regarding experiences of pediatric survivors’ coping with schooling since that time.

Methods
This article presents exploratory mixed methods findings from a quality improvement project including qualitative interviews and a quantitative survey conducted with parents of pediatric oncology survivors identified through neuropsychological assessment, and the use of school-based services as having educationally relevant neurocognitive impacts of disease or treatment. The interviews explored experiences of education and instructional delivery during the COVID-19 school closures in spring of 2020 and the beginning of the 2020–2021 school year and served as the foundation for a quantitative survey to determine the generalizability of findings.

Results
Qualitative interviews highlighted 3 emergent themes regarding the shared experiences of distance schooling for children with cancer during the COVID-19 school closures: (a) attention, (b) mental health, and (c) access to instruction. A follow-up quantitative survey supported the qualitative findings and their generalizability to the schooling experiences of other children with cancer during the pandemic.

Conclusion
This article describes and explores each theme and offers suggestions for pediatric supports and changes to provider service delivery (including weblinks to access project-developed resources) as a result of ongoing pandemic-related schooling needs.
The Ghosts of Lilith: haunting narratives of witness and the postcolonial poetry of Shivanee Ramlochan
Authors: Darroch Fiona , Jasper Alison 
Published: September 2021

Abstract
This article discusses some of the themes and implications of Lilith’s story. After setting the figure of Lilith in an historical context of Sumerian demonology and first millennium CE Babylonian midrash, we reflect on the current critical, feminist, postcolonial, and poetic up-take of this curious tale of Adam’s first wife. We consider how Lilith’s story appears in these readings, woven through migrated narratives of loss and trauma drawn from widely different communities, as a thread of ghostly witness to suffering and resilience within the everyday lives of women and others who have been bound by heteropatriarchal and colonial tropes and traditions, to the materiality of the body in birth, vulnerability to violence and death. Briefly illustrating Lilith as expressed in George MacDonald’s Lilith (1895), we draw on the work of Gayatri Spivak and Mayra Rivera to explore contemporary traces of Lilith’s presence in the writings ofAlicia Ostriker and, especially, Trinidadian poet, Shivanee Ramlochan. In reference to Ramlochan’s debut collection, Everyone Knows I am a Haunting (2017) we consider how Lilith is used to challenge these limiting tropes and traditions, giving value to complex identities and material existences that resist efforts to impose silence or contest memories that trouble and unsettle.
Black hole fuelling in galaxy mergers: a high-resolution analysis
Authors: Prieto Joaquin , Escala Andrés , Privon George C , d’Etigny Juan 
Published: September 2021

ABSTRACT
Using parsec scale resolution hydrodynamical adaptive mesh refinement simulations, we have studied the mass transport process throughout a Galactic merger. The aim of such study is to connect both the peaks of mass accretion rate on to the BHs and star formation bursts with both gravitational and hydrodynamic torques acting on the galactic gaseous component. Our merger initial conditions were chosen to mimic a realistic system. The simulations include gas cooling, star formation, supernovae feedback, and AGN feedback. Gravitational and hydrodynamic torques near pericentre passes trigger gas funneling to the nuclei that is associated with bursts of star formation and black hole growth. Such episodes are intimately related with both kinds of torques acting on the galactic gas. Pericentres trigger both star formation and mass accretion rates of ∼few $(1\!-\!10)\, \mathrm{ M}_\odot$ yr−1. Such episodes last $\sim \, (50\!-\!75)$ Myr. Close passes also can produce black hole accretion that approaches and reaches the Eddington rate, lasting ∼few Myrs. Our simulation shows that both gravitational and hydrodynamic torques are enhanced at pericentre passes with gravitational torques tending to have higher values than the hydrodynamic torques throughout the merger. We also find that in the closest encounters, hydrodynamic and gravitational torques can be comparable in their effect on the gas, the two helping in the redistribution of both angular momentum and mass in the galactic disc. Such phenomena allow inward mass transport on to the BH influence radius, fuelling the compact object and lighting up the galactic nuclei.
Ionizing radiation from AGNs at z &gt; 3.3 with the Subaru Hyper Suprime-Cam Survey and the CFHT Large Area U-band Deep Survey (CLAUDS)
Authors: Iwata Ikuru , Sawicki Marcin , Inoue Akio K , Akiyama Masayuki , Micheva Genoveva , Kawaguchi Toshihiro , Kashikawa Nobunari , Gwyn Stephen , Arnouts Stephane , Coupon Jean , Desprez Guillaume 
Published: September 2021

ABSTRACT
We use deep and wide imaging data from the CFHT Large Area U-band Deep Survey (CLAUDS) and the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) to constrain the ionizing radiation (Lyman Continuum, LyC) escape fraction from active galactic nuclei (AGNs) at z ∼ 3–4. For 94 AGNs with spectroscopic redshifts at 3.3 &lt; z &lt; 4.0, we use their U/i-band flux ratios to estimate LyC transmission of individual AGNs. The distribution of their LyC transmission shows values lower than the range of LyC transmission values for IGM of the same redshift range, which suggests that LyC escape fraction of AGNs at z &gt; 3.3 is considerably lower than unity in most cases. We do not find any trend in LyC transmission values depending on their UV luminosities. Based on the photometry of stacked images we find the average flux ratio of LyC and non-ionizing UV photons escaping from the objects (fLyC/fUV)out = 0.182 ± 0.043 for AGNs at 3.3 &lt; z &lt; 3.6, which corresponds to LyC escape fraction fesc = 0.303 ± 0.072 if we assume a fiducial intrinsic SED of AGN. Based on the estimated LyC escape fraction and the UV luminosity function (UVLF) of AGNs, we argue that UV-selected AGNs’ contribution to the LyC emissivity at the epoch is minor, although the size of their contribution largely depends on the shape of the UVLF.
Semi-analytic forecasts for JWST – V. AGN luminosity functions and helium reionization at z = 2–7
Authors: Yung L Y Aaron , Somerville Rachel S , Finkelstein Steven L , Hirschmann Michaela , Davé Romeel , Popping Gergö , Gardner Jonathan P , Venkatesan Aparna 
Published: September 2021

ABSTRACT
Active galactic nuclei (AGN) forming in the early universe are thought to be the primary source of hard ionizing photons contributing to the reionization of intergalactic helium. However, the number density and spectral properties of high-redshift AGN remain largely unconstrained. In this work, we make use of physically informed models calibrated with a wide variety of available observations to provide estimates for the role of AGN throughout the Epoch of Reionization. We present AGN luminosity functions in various bands between z = 2 and 7 predicted by the well-established Santa Cruz semi-analytic model, which includes modelling of black hole accretion and AGN feedback. We then combine the predicted AGN populations with a physical spectral model for self-consistent estimates of ionizing photon production rates, which depend on the mass and accretion rate of the accreting supermassive black hole. We then couple the predicted comoving ionizing emissivity with an analytic model to compute the subsequent reionization history of intergalactic helium and hydrogen. This work demonstrates the potential of coupling physically motivated analytic or semi-analytic techniques to capture multiscale physical processes across a vast range of scales (here, from AGN accretion discs to cosmological scales). Our physical model predicts an intrinsic ionizing photon budget well above many of the estimates in the literature, meaning that helium reionization can comfortably be accomplished even with a relatively low escape fraction. We also make predictions for the AGN populations that are expected to be detected in future James Webb Space Telescope surveys.