bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotempo﻿ral evolution analysis of NO2 column density before and after COVID-19 pandemic in Henan province based on SI-APSTE model
Authors: Liu Yang , Zhao Jinhuan , Song Kunlin , Cheng Cheng , Li Shenshen , Cai Kun 
Published: September 2021

AbstractAir pollution is the result of comprehensive evolution of a dynamic and complex system composed of emission sources, topography, meteorology and other environmental factors. The establishment of spatiotemporal evolution model is of great significance for the study of air pollution mechanism, trend prediction, identification of pollution sources and pollution control. In this paper, the air pollution system is described based on cellular automata and restricted agents, and a Swarm Intelligence based Air Pollution SpatioTemporal Evolution (SI-APSTE) model is constructed. Then the spatiotemporal evolution analysis method of air pollution is studied. Taking Henan Province before and after COVID-19 pandemic as an example, the NO2products of TROPOMI and OMI were analysed based on SI-APSTE model. The tropospheric NO2Vertical Column Densities (VCDs) distribution characteristics of spatiotemporal variation of Henan province before COVID-19 pandemic were studied. Then the tropospheric NO2VCDs of TROPOMI was used to study the pandemic period, month-on-month and year-on-year in 18 urban areas of Henan Province. The results show that SI-APSTE model can effectively analyse the spatiotemporal evolution of air pollution by using environmental big data and swarm intelligence, and also can establish a theoretical basis for pollution source identification and trend prediction.
Model-based analysis of multi-UAV path planning for surveying postdisaster building damage
Authors: Nagasawa Ryosuke , Mas Erick , Moya Luis , Koshimura Shunichi 
Published: September 2021

AbstractEmergency responders require accurate and comprehensive data to make informed decisions. Moreover, the data should be acquired and analyzed swiftly to ensure an efficient response. One of the tasks at hand post-disaster is damage assessment within the impacted areas. In particular, building damage should be assessed to account for possible casualties, and displaced populations, to estimate long-term shelter capacities, and to assess the damage to services that depend on essential infrastructure (e.g. hospitals, schools, etc.). Remote sensing techniques, including satellite imagery, can be used to gathering such information so that the overall damage can be assessed. However, specific points of interest among the damaged buildings need higher resolution images and detailed information to assess the damage situation. These areas can be further assessed through unmanned aerial vehicles and 3D model reconstruction. This paper presents a multi-UAV coverage path planning method for the 3D reconstruction of postdisaster damaged buildings. The methodology has been implemented in NetLogo3D, a multi-agent model environment, and tested in a virtual built environment in Unity3D. The proposed method generates camera location points surrounding targeted damaged buildings. These camera location points are filtered to avoid collision and then sorted using the K-means or the Fuzzy C-means methods. After clustering camera location points and allocating these to each UAV unit, a route optimization process is conducted as a multiple traveling salesman problem. Final corrections are made to paths to avoid obstacles and give a resulting path for each UAV that balances the flight distance and time. The paper presents the details of the model and methodologies, and an examination of the texture resolution obtained from the proposed method and the conventional overhead flight with the nadir-looking method used in 3D mappings. The algorithm outperforms the conventional method in terms of the quality of the generated 3D model.
Comprehensive mineralogical and physicochemical characterization of recent sapropels from Romanian saline lakes for potential use in pelotherapy
Authors: Baricz Andreea , Levei Erika A. , Șenilă Marin , Pînzaru Simona Cîntă , Aluaş Mihaela , Vulpoi Adriana , Filip Claudiu , Tripon Carmen , Dădârlat Dorin , Buda Doriana M. , Dulf Francisc V. , Pintea Adela , Cristea Adorján , Muntean Vasile , Keresztes Zsolt G. , Alexe Mircea , Banciu Horia Leonard 
Published: September 2021

AbstractIn this study we aimed to compare the mineralogical, thermal, physicochemical, and biological characteristics of recent organic carbon-rich sediments (‘sapropels’) from three geographically distant Romanian lakes (Tekirghiol and Amara, SE Romania, and Ursu, Central Romania) with distinct hydrogeochemical origins, presently used for pelotherapy. The investigated lakes were classified as inland brackish Na-Cl-sulfated type (Amara), coastal moderately saline and inland hypersaline Na-Cl types (Tekirghiol and Ursu, respectively). The settled organic matter is largely composed of photosynthetic pigments derived from autochthonous phytoplankton. Kerogen was identified in the sapropel of coastal Tekirghiol Lake suggesting its incipient maturation stage. The mineral composition was fairly similar in all sapropels and mainly consisted of quartz, calcite, and aragonite. Smectite, illite, mixed layer smectite/illite appeared as major clay components. Potentially toxic elements were found in low concentrations. The physical properties (i.e., specific heat, thermal conductivity and retentivity) and cation exchange capacity are comparable to other peloids used for therapy. This study is the first comprehensive multi-approached investigation of the geochemical nature of recent sapropels in Romanian saline lakes and thus contributes to expanding our knowledge on the origin and physicochemical qualities of organic matter-rich peloids with therapeutic uses.
The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility
Authors: Tan Shing Cheng , Low Teck Yew , Mohamad Hanif Ezanee Azlina , Sharzehan Mohamad Ayub Khan , Kord-Varkaneh Hamed , Islam Md Asiful 
Published: September 2021

AbstractTheESR1rs9340799 polymorphism has been frequently investigated with regard to its association with breast cancer (BC) susceptibility, but the findings have been inconclusive. In this work, we aimed to address the inconsistencies in study findings by performing a systematic review and meta-analysis. Eligible studies were identified from the Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, VIP and Wanfang databases based on the predefined inclusion and exclusion criteria. The pooled odds ratio (OR) was then calculated under five genetic models: homozygous (GG vs. AA), heterozygous (AG vs. AA), dominant (AG + GG vs. AA), recessive (GG vs. AA + AG) and allele (G vs. A). Combined results from 23 studies involving 34,721 subjects indicated a lack of significant association between the polymorphism and BC susceptibility (homozygous model, OR = 1.045, 95% CI 0.887–1.231, P = 0.601; heterozygous model, OR = 0.941, 95% CI 0.861–1.030, P = 0.186; dominant model, OR = 0.957, 95% CI 0.875–1.045, P = 0.327; recessive model, OR = 1.053, 95% CI 0.908–1.222, P = 0.495; allele model, OR = 0.987, 95% CI 0.919–1.059, P = 0.709). Subgroup analyses by ethnicity, menopausal status and study quality also revealed no statistically significant association (P > 0.05). In conclusion, our results showed that theESR1rs9340799 polymorphism was not associated with BC susceptibility, suggesting its limited potential as a genetic marker for BC.
Detecting halfmetallic electronic structures of spintronic materials in a magnetic field
Authors: Fujiwara H. , Umetsu R. Y. , Kuroda F. , Miyawaki J. , Kashiuchi T. , Nishimoto K. , Nagai K. , Sekiyama A. , Irizawa A. , Takeda Y. , Saitoh Y. , Oguchi T. , Harada Y. , Suga S. 
Published: September 2021

AbstractBand-gap engineering is one of the fundamental techniques in semiconductor technology and also applicable in next generation spintronics using the spin degree of freedom. To fully utilize the spintronic materials, it is essential to optimize the spin-dependent electronic structures in the operando conditions by applying magnetic and/or electric fields. Here we present an advanced spectroscopic technique to probe the spin-polarized electronic structures by using magnetic circular dichroism (MCD) in resonant inelastic soft X-ray scattering (RIXS) under an external magnetic field. Thanks to the spin-selective dipole-allowed transitions in RIXS-MCD, we have successfully demonstrated the direct evidence of the perfectly spin-polarized electronic structures for the prototypical halfmetallic Heusller alloy $$\hbox {Co}_2\hbox {MnSi}$$

Co
2

MnSi

. RIXS-MCD is a promising tool to probe the spin-dependent carriers and band-gap induced in the buried magnetic layers in an element specific way under the operando conditions.
Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice
Authors: Rhea Elizabeth M. , Hansen Kim , Pemberton Sarah , Torres Eileen Ruth S. , Holden Sarah , Raber Jacob , Banks William A. 
Published: September 2021

AbstractAge, apolipoprotein E (apoE) isoform, sex, and diet can independently affect the risk for the development of Alzheimer’s disease (AD). Additionally, synergy between some of these risk factors have been observed. However, the relation between the latter three risk factors has not been investigated. Central nervous system (CNS) insulin resistance is commonly involved in each of these risk factors. CNS insulin is primarily derived from the periphery in which insulin must be transported across the blood–brain barrier (BBB). Additionally, insulin can bind the brain endothelial cell to affect intracellular signaling. Therefore, we hypothesized CNS access to insulin could be affected by the combination of apoE isoform, sex, and diet. We analyzed insulin BBB pharmacokinetics in aged apoE targeted replacement (E3 and E4) male and female mice on a low-fat and high-fat diet. There were differences within males and females due to apoE genotype and diet in insulin interactions at the BBB. These sex-, diet-, and apoE isoform-dependent differences could contribute to the cognitive changes observed due to altered CNS insulin signaling.
Host selection pattern and flavivirus screening of mosquitoes in a disturbed Colombian rainforest
Authors: Hoyos Juliana , Carrasquilla María Cristina , León Cielo , Montgomery Joel M. , Salyer Stephanie J. , Komar Nicholas , González Camila 
Published: September 2021

AbstractStudies on the feeding behavior of hematophagous insects, particularly those of medical importance, are relevant for tracking possible pathogen transmission routes and identifying biases in the choice of vertebrates. We evaluated host selection of blood-feeding mosquitoes in a disturbed forest in the Magdalena Medio valley in Colombia from March 2017 to April 2018, after the introduction of Zika virus to the Americas from the 2015–2016 outbreak. We estimated vertebrate diversity and collected blood-engorged female mosquitoes. Genomic DNA/RNA was extracted from the mosquito’s abdomen for vertebrate host identification and pathogen detection. We performed conventional PCR and sequencing, using universal primers targeting vertebrate regions of the eukaryotic mitochondrial genome to determine bloodmeal host. Additionally, we tested for the presence of flaviviruses in all mosquito samples with RT-PCR. Based on the identity and quantity of detected bloodmeals, we performed mosquito-vertebrate interaction network analysis and estimated topology metrics. In total, we collected 292 engorged female mosquitoes representing 20 different species. Bloodmeal analyses identified 26 vertebrate species, the majority of which were mammals (N = 16; 61.5%). No flaviviruses of medical importance were detected from the samples. Although feeding patterns varied, network analyses showed a high degree of specialization by mosquitoes and revealed ecological and phylogenetic relationships among the host community. We conclude that host selection or preference by mosquitoes is species specific.
In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
Authors: Tan Yeong Lan , Nga Min En , Ho Han Kiat 
Published: September 2021

AbstractModerate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propose the use of pulsed cooling for regional hypothermic conditioning in liver. This involves intermittent cooling applied in pulses of 15 min each, with a one-hour recovery interval between pulses. Cooling is achieved by applying ice packs to the cutaneous region overlying the liver. Through an in vivo C57BL/6NTac mouse study, we demonstrated the feasibility of attaining localized hypothermia close to the liver while maintaining core body temperature. This has successfully ameliorated acetaminophen-induced liver injury based on the liver function tests, liver histology and total weight change. Collectively, we provide a proof of concept for pulsed external localized cooling as being clinically actionable to perform induced selective hypothermia.
Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization
Authors: Bhattacharya Ushashi , Jhou Jia-Fong , Zou Yi-Fong , Abrigo Gerald , Lin Shu-Wei , Chen Yun-Hsuan , Chien Fan-Ching , Tai Hwan-Ching 
Published: September 2021

AbstractSynaptosomes are subcellular fractions prepared from brain tissues that are enriched in synaptic terminals, widely used for the study of neural transmission and synaptic dysfunction. Immunofluorescence imaging is increasingly applied to synaptosomes to investigate protein localization. However, conventional methods for imaging synaptosomes over glass coverslips suffer from formaldehyde-induced aggregation. Here, we developed a facile strategy to capture and image synaptosomes without aggregation artefacts. First, ethylene glycol bis(succinimidyl succinate) (EGS) is chosen as the chemical fixative to replace formaldehyde. EGS/glycine treatment makes the zeta potential of synaptosomes more negative. Second, we modified glass coverslips with 3-aminopropyltriethoxysilane (APTES) to impart positive charges. EGS-fixed synaptosomes spontaneously attach to modified glasses via electrostatic attraction while maintaining good dispersion. Individual synaptic terminals are imaged by conventional fluorescence microscopy or by super-resolution techniques such as direct stochastic optical reconstruction microscopy (dSTORM). We examined tau protein by two-color and three-color dSTORM to understand its spatial distribution within mouse cortical synapses, observing tau colocalization with synaptic vesicles as well postsynaptic densities.
Study on hyperspectral estimation model of soil organic carbon content in the wheat field under different water treatments
Authors: Yang Chenbo , Feng Meichen , Song Lifang , Wang Chao , Yang Wude , Xie Yongkai , Jing Binghan , Xiao Lujie , Zhang Meijun , Song Xiaoyan , Saleem Muhammad 
Published: September 2021

AbstractHyperspectral remote sensing technology can be used to monitor the soil nutrient changes in a rapid, real-time, and non-destructive manner, which is of great significance to promote the development of precision agriculture. In this paper, 225 soil samples were studied. The effects of different water treatments on soil organic carbon (SOC) content, and the relationship between SOC content and spectral reflectance (350–2500 nm) were studied. 17 kinds of preprocessing algorithm were performed on the original spectral (R), and the five allocation ratios of calibration to verification sets were set. Finally, the model was constructed by partial least squares regression (PLSR). The results showed that the effects of water treatment on SOC content were different in different growth stages of winter wheat. Results of correlation analysis showed that the differential transformation can refine the spectral characteristics, and improve the correlation between SOC content and spectral reflectance. Results of model construction showed that the models constructed by second-order differential transformation were not good. But the ratio of standard deviation to the standard prediction error (RPD) values of the models were constructed by simple mathematical transformation (T0–T5) and first-order differential transformation (T6–T11) can reach more than 1.4. The simple mathematical transformation (T0–T2, T4–T5) and the first-order differential transformation (T6–T10) resulted in the highest RPD in mode 5 and mode 2, respectively. Among all the models, the model of T7 in mode 2 reach the highest accuracy with a RPD value of 1.9861. Therefore, it is necessary to consider the data preprocessing algorithm and allocation ratio in the process of constructing the hyperspectral monitoring model of SOC.
Action video game training improves text reading accuracy, rate and comprehension in children with dyslexia: a randomized controlled trial
Authors: Peters Jessica L. , Crewther Sheila G. , Murphy Melanie J. , Bavin Edith L. 
Published: September 2021

AbstractDynamic visual attention training using Action Video Games (AVGs) is a promising intervention for dyslexia. This study investigated the efficacy of 5 h (10 × 30 min) of AVG training in dyslexic children (aged 8–13) using ‘Fruit Ninja’, while exploring whether increasing attentional and eye movement demands enhanced AVG effectiveness. Regular (AVG-R; n = 22) and enhanced AVG training (AVG+; n = 23) were compared to a treatment-as-usual comparison group (n = 19) on reading, rapid naming, eye movements and visuo-temporal processing. Playing ‘Fruit Ninja’ for only 5 h significantly improved reading accuracy, rate, comprehension and rapid naming of both AVG groups, compared to the comparison group, though increasing attentional demands did not enhance AVG efficacy. Participants whose low contrast magnocellular-temporal processing improved most following training also showed significantly greater improvement in reading accuracy. The findings demonstrate a clear role for visual attention in reading and highlight the clinical applicability of AVGs as a fun, motivational and engaging intervention for dyslexia.
Analysis on vertical–pitch coupled dynamics characteristics of shearer with corrected load
Authors: Yang Xinwei , Chen Hongyue , Li Pengfei , Wang Xin , Wei Yajing 
Published: September 2021

AbstractWith regard to the severe vertical and pitching vibration of shearer in actual working conditions, the vertical–pitch coupled dynamics model of shearer with 13 degrees of freedom was established using multi-body dynamics theory. Based on the elasticity theory, Hertz contact and collision dynamics, the connection stiffness model of shear body and the traction section, the rocker arm with clearance and the traction section, the support stiffness models for the guide shoe and the smooth shoe, and the stiffness characteristics model of the rocker arm were constructed respectively. Taking into account the convergence of solution process and the reliability of results, a modified drum load was proposed as the external excitation of the system and the dynamic characteristics of key parts of shearer under different working conditions were analyzed. The numerical models were validated against the vibration responses of the whole machine and critical components of shearer obtained from mechanical test under different operating conditions. The research results provide theoretical basis for the structure optimization and process parameter optimization of shearer.
Microsporidia MB is found predominantly associated with Anopheles gambiae s.s and Anopheles coluzzii in Ghana
Authors: Akorli Jewelna , Akorli Esinam Abla , Tetteh Seraphim Naa Afoley , Amlalo Godwin Kwame , Opoku Millicent , Pwalia Rebecca , Adimazoya Michelle , Atibilla Dorcas , Pi-Bansa Sellase , Chabi Joseph , Dadzie Samuel Kweku 
Published: September 2021

AbstractA vertically transmitted microsporidian, Microsporidia MB, with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa. To demonstrate its range of incidence, archived DNA samples from 7575 Anopheles mosquitoes collected from Ghana were screened. MB prevalence was observed at 1.8%. An. gambiae s.s constituted 87% of positive mosquitoes while the remaining were from An. coluzzii. Both sibling species had similar positivity rates (24% and 19%; p = 0.42) despite the significantly higher number of An. gambiae s.s analysed (An. gambiae s.s = 487; An. coluzzii = 94; p = 0.0005). The microsporidian was also more prevalent in emerged adults from field-collected larvae than field-caught adults (p < 0.0001) suggestive of an efficient vertical transmission and/or horizontal transfer among larvae. This is the first report of Microsporidia MB in Anopheles mosquitoes in West Africa. It indicates possible widespread among malaria vector species and warrants investigations into the symbiont’s diversity across sub-Saharan Africa.
Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
Authors: Patel Onisha , Roy Michael J. , Kropp Ashleigh , Hardy Joshua M. , Dai Weiwen , Lucet Isabelle S. 
Published: September 2021

AbstractDoublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. However, the presence of tissue-specific spliced DCLK1 isoforms with distinct biological functions have challenged the development of effective strategies to understand the role of DCLK1 in oncogenesis. Recently, DCLK1-IN-1 was reported as a highly selective DCLK1 inhibitor, a powerful tool to dissect DCLK1 biological functions. Here, we report the crystal structures of DCLK1 kinase domain in complex with DCLK1-IN-1 and its precursors. Combined, our data rationalises the structure-activity relationship that informed the development of DCLK1-IN-1 and provides the basis for the high selectivity of DCLK1-IN-1, with DCLK1-IN-1 inducing a drastic conformational change of the ATP binding site. We demonstrate that DCLK1-IN-1 binds DCLK1 long isoforms but does not prevent DCLK1’s Microtubule-Associated Protein (MAP) function. Together, our work provides an invaluable structural platform to further the design of isoform-specific DCLK1 modulators for therapeutic intervention.