bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA MIAT as a Stemness-Associated Transcript Regulates the Proliferation, Migration and Metastasis of Glioma
Authors: Amirmahani Farzane , Asadi Malek Hossein , Vallian Sadeq 
Published: June 2021

Abstract
Purpose: Glioma is the most prevalent category of brain tumors with cancer stem cells. Myocardial infarction-associated transcript (MIAT) is a long non-coding RNA (lncRNA), with altered expression in different diseases and cancers. The purpose of this study was to evaluate the functional role of lncRNA MIAT in glioma.Methods: In this study, lncRNA MIAT expression was evaluated in the TCGA database in common cancers and glioma specimens. The expression of lncRNA MIAT was knocked down by the RNA interference method, and its effects on the characteristics of two glioma cancer cell lines, A172 and U-87MG, were investigated. Results: The findings of the bioinformatics analysis showed an increase in the expression level of lncRNA MIAT in 12 common cancers. The expression of lncRNA MIAT was much greater in glioma tumor tissues compared to other ones. Knocking-down of lncRNA MIAT led to the reduction of proliferation of glioma cancer cells followed by cell cycle arrest at G1 phase. Furthermore, the inhibition of expression of lncRNA MIAT significantly induced apoptosis, senescence and autophagy, but limited the migration ability and Epithelial-Mesenchymal-Transition (EMT) of cancer cells. Moreover, knocking-down of lncRNA MIAT reduced the expression of stemness factors including Oct4, Sox2, and Nanog. This resulted in the upregulation of their downstream miRNAs (micro RNAs), let-7a-5p and miR-29b-3p. Conclusion: Altogether, our findings showed that lncRNA MIAT could control proliferation, migration and metastasis of glioma cells by regulating the Nanog/ Sox2 / MAP1LC3B2/ let-7a-5p / miR-29b-3p axis. These observations proposed that lncRNA MIAT could be considered as a new oncogene in glioma.
Efficacy and Safety of Modified Qing-Ying Decoction for Atopic Dermatitis in Children: Study Protocol for a Randomized Controlled Trial
Authors: LAI Mei Kwan , SUM Chi Him , KAM Connie YC , SONG Tianhe , CHEONG Pui Kuan , CHAN Kam Leung , LOO Steven KF , HON Ellis KL , ZHANG Hongwei , LO Louis CW , CHING Jessica YL , LIN Zhi-Xiu 
Published: June 2021

Abstract
BackgroundAtopic Dermatitis (AD), also known as atopic eczema, is a chronic skin disease characterized by recurring episodes of itchiness with skin erythema and surface damages, such as dry skin, skin thickening and swelling. Long-term treatment with conventional medicine for subacute and moderate atopic eczema is not satisfactory. Evidence from randomized clinical trials suggests the effectiveness of Chinese medicine for the treatmement of AD. The purpose of this study is to explore the efficacy and safety of the modified Qing-Ying Decoction (mQYD) for the treatment of subacute and chronic AD in children through examining the clinical symptoms, quality of life, gut microbiome, and Chinese medicine (CM) body constitution.Methods/designThis is a parallel, randomized, placebo-controlled, double-blind clinical trial with a 12-week treatment and a 4-week follow-up period. A total of 64 participants will be randomly allocated to the treatment group receiving oral mQYD granules or the placebo control group receiving oral placebo granules. Eczema Area and Severity Index (EASI) score will be the primary outcome. Secondary outcome measures include change in symptoms using the Patient-Oriented Eczema Measure (POEM), the Children’s Dermatology Life Quality Index (CDLQI), and the use of concomitant medicines as well as the change in the gut microbiome and CM body constitution types after the 12-week treatment of the mQYD and 4-week follow-up compared to placebo control. Safety parameters include report of adverse events and pathology tests during the trial period.DiscussionThis is the first clinical trial of its kind to test the efficacy and gut microbiome of an innovative Chinese herbal formula modified from a famous ancient formula for the treatment of AD. The outcomes of this trial will provide clinical evidence on the effectiveness and safety of mQYD for the treatment of AD.Trial registrationClinicalTrials.gov, ID: NCT04419584. Registered on 28 July 2020.
A Luteinizing Hormone-based Protocol Versus Traditional Flexible Gonadotropin-Releasing Hormone Antagonist Protocol in Women with Normal Ovarian Response: Study Protocol for a non-Inferiority Trial
Authors: Lv Ya-su , Li Yuan , Liu Shan 
Published: June 2021

Abstract
BackgroundUse of gonadotropin-releasing hormone (GnRH) antagonists during the late follicular phase can prevent premature luteinizing hormone (LH) surge. Many patients demonstrate an insufficient endogenous LH concentration during ovarian stimulation. Previous studies have demonstrated that ultra-low LH concentration influences pregnancy outcomes. However, affected patients cannot be distinguished prior to ovarian stimulation using baseline characteristics alone. With traditional fixed or flexible GnRH antagonist protocols, antagonist administration may further reduce LH activity. Previously, we proved that LH can be used as an indicator for the timing and dosage of antagonist. Patients with a persistently low LH concentration during ovarian stimulation may not require antagonists, whereas antagonist administration can affect reproductive outcomes. To further explore this hypothesis, we designed a randomized clinical trial to compare the LH-based flexible GnRH antagonist protocol with traditional flexible GnRH antagonist protocol in women with normal ovarian response. MethodsThis study was a multicenter, parallel, prospective, randomized, non-inferiority study. The primary efficacy endpoint was cumulative ongoing pregnancy rate per cycle. The study aimed to prove the non-inferiority of cumulative ongoing pregnancy rate per cycle with a LH-based flexible GnRH antagonist protocol versus traditional flexible GnRH antagonist protocol. Secondary endpoints were the high-quality embryo rate, clinical pregnancy rate, and cancellation rate. Differences in cost-effectiveness and adverse events were evaluated. The cumulative ongoing pregnancy rate per cycle in women with normal ovarian response was 70%. Considering that a non-inferiority threshold should retain 80% of the clinical effect of a control treatment, a minimal clinical difference of 14% (one-sided: α, 2.5%; β, 20%) and a total of 338 patients were needed. Anticipating a 10% dropout rate, the total number of patients required was 372.DiscussionThis is the first randomized controlled trial to compare the efficacy of a LH-based treatment regimen with a traditional flexible GnRH antagonist protocol during ovarian stimulation. We hypothesized no significant difference in cumulative ongoing pregnancy rate per cycle between the two protocols. Moreover, patients with insufficient endogenous LH during ovarian stimulation may benefit from LH-based GnRH antagonist protocols. The results will provide new information on when to introduce antagonists and the appropriate dosage of antagonist.Trial registration: ClinicalTrials.gov, ChiCTR1800018077. Registered on 29 August, 2018.
Small area estimates of the low work intensity indicator at voivodeship level in Poland
Authors: Wawrowski Łukasz , Beresewicz Maciej 
Published: June 2021

Abstract
The EU Statistics on Income and Living Conditions (EU-SILC) has provided annual estimates of the number of labour market indicators for EU countries since 2003, with an almost exclusive focus on national rates. However, it is impossible to obtain reliable direct estimates of labour market statistics at low levels based on the EU-SILC survey. In such cases, model-based small area estimation can be used. In this paper, the low work intensity indicator for the spatial domains in Poland between 2005-2012 was estimated. The Rao and You (1994), Fay and Diallo (2012), and Marhuenda, Molina and Morales (2013) models were applied. The bootstrap MSE for the discussed methods was proposed. The results indicate that these models provide more reliable estimates than direct estimation.
A dynamic MST-deltaCoVaR model of systemic risk in the European insurance sector
Authors: Denkowska Anna , Wanat Stanisław 
Published: June 2021

Abstract
This work is a response to the EIOPA paper entitled ‘Systemic risk and macroprudential policy in insurance’, which asserts that in order to evaluate the potential systemic risk (SR), the build-up of risk, especially risk arising over time, should be taken into account, as well as the interlinkages occurring in the financial sector and the whole economy. The topological indices of minimum spanning trees (MST) and the deltaCoVaR measure are the main tools used to analyse the systemic risk dynamics in the European insurance sector in the years 2005-2019. The article analyses the contribution of each of the 28 largest European insurance companies, including those appearing on the G-SIIs list, to systemic risk. Moreover, the paper aims to determine whether the most important contribution to systemic risk is made by companies with the highest betweenness centrality or the highest degree in the obtained MST.
Elevated tanks effect on transient pressures: case study
Authors: Darweesh Moustafa S. 
Published: June 2021

Abstract
Elevated tanks are an integral part of the water supply networks. This paper highlights the effect of elevated tanks' location and size on the transient pressures resulting from the sudden failure of pumps. A comparison between the impact of elevated tanks and air vessels on the water hammer was also performed. The Bentley HAMMER model was first validated then applied to analyze the unsteady flow within an actual distribution network. The results display that the elevated tanks have a considerable effect on the surge pressures, where they improve the extreme pressures effectively at and around them, but they cannot fully protect the system from the water hammer risks, as there are still relatively large negative pressures at some distant junctions. Besides, as the tank capacity increases, the surge pressures increase slightly. In our case study, the best location of the elevated tank is at the network extremity and then at the pumping stations, since the minimum pressures improve by 67 and 54%, respectively. Although the present case study may differ from other supply systems, the obtained results can provide an indication of the elevated tanks' role in alleviating undesirable water hammer effects.
Preparation of cellulose nanofiltration membranes and their removal of typical pollutants from drinking water
Authors: Weng Rengui , Tian Feng , Huang Xin , Ni Liufang , Xi Beidou 
Published: June 2021

Abstract
Cellulose membranes have the advantages of good hydrophilicity, excellent mechanical properties, and biodegradability. Therefore, they are the first choice to replace petroleum polymer membranes. In this study, cellulose (BC) and chitosan (CS) were used as raw materials, and N-methylmorpholine-N-oxide (NMMO) was used as solvent. A new kind of cellulose nanofiltration membrane (BC-NFM), cellulose/chitosan nanofiltration membrane (BC/CS-NFM), and interfacial polymerized cellulose/chitosan composite nanofiltration membrane (IP-BC/CS-NFM) were successfully prepared by NaOH hydrolysis and chloroacetic acid carboxymethylation modification, piperazine (PIP), and 1,3,5-trimellitic chloride (TMC) interfacial polymerization, respectively. These two methods were used for the preparation of cellulose nanofiltration membranes for the first time.We also studied their structure, separation performance and their capacity to remove typical pollutants. The results showed that obvious holes appeared on the surface of the nanofiltration membrane obtained by alkali hydrolysis and chloroacetic acid carboxymethylation modification, and the cross-section showed a spongelike structure. The surface of the nanofiltration membrane obtained by interfacial polymerization formed a rough and dense separation layer. The rejection rates of the three kinds of nanofiltration membranes were all over 30% for monovalent salt ions, over 60% for divalent salt ions, over 92% for methyl orange, and over 98% for methyl blue. They had good removal effects for typical pollutants in drinking water.
A supervisory fuzzy logic control scheme to improve effluent quality of a wastewater treatment plant
Authors: Saravana Kumar S. , Latha K. 
Published: June 2021

AbstractThe application of control strategies in wastewater treatment plants has increased to improve their performance for treating influent. The fuzzy logic controller plays a vital role in this work and simulation work was carried out in a benchmark simulation model no.1 (BSM1) framework. The attempted work proposes two control schemes with the objectives of improving the effluent quality and minimizing the number of measurements taken from the plant. The design of fuzzy control schemes is based on five inputs and six outputs in order to accomplish the objectives. Experimental results show improvement in the effluent quality and increase in the efficacy of the control system. The proposed design is implemented using MATLAB with the adaptation in 2014a.
Implementation of cybernetic learning theory on scientific philosophy learning
Authors: Furaida Laily 
Published: June 2021

The topic is focused on cybernetic learning theory and its implementation to scientific philoshophy learning. Theoretical approach and scientific learning can be connected each other with the same purposes on learning process. Cybernetic learning theory attent to information processing substance and organize its connection to be come an information system which is creating a new idea or a new invention of science. Due to this, the main purpose of scientific philosophy learning is a critical thinking process which construct a new idea that is engaging a kognitive aspect.This research is a literature review. Literature review is a research which compare previous research then connected with a topic that be come a main review (Efron Ravid, 2019). The research design is narrative review. Narrative review well known as traditional literature review which is a literature review with an analysis as a whole in order to construct a theory and context of a research main focus (Stratton, 2019).The implementation of cybernetic learning theory are suitable for scientific philosophy learning for the same goal in order to find out and proceed new information. Information processing theory which is include kognitive aspect has an important role of cybernetic approach. Cybernetic learning theory can be applied on every learning method which is connecting kognitive aspect in its process.
Optimasi Biaya dan Waktu Proyek Konstruksi dengan Lembur dan Penambahan Tenaga Kerja
Authors: Fardila Dinda , Adawyah Nuur Robbyatul 
Published: June 2021

ABSTRACT In the construction of a construction project, there are three main elements: time efficiency, minimal costs, and appropriate quality. This study aims to calculate changes in the cost and time of project implementation with variations in overtime and additional workforce. Data analysis using Microsoft Project 2010 program and Time-Cost Trade-Off method. The results of this study indicate that (1) the optimum time and costs due to overtime are obtained at the project age of 235 working days with a total project cost of IDR 8,438,038,832 with a project time efficiency of 5 days (2.13%) and a project cost efficiency of IDR 3.559,695 (0.042%). (2) The optimum time and cost due to the addition of labor is the best choice with the results obtained at the project age of 226 working days with a total project cost of IDR 8,429,832,759 with a project time efficiency of 14 days (6.19%) and cost-efficiency. project amounting to Rp. 11,779,674 (0.14%). ABSTRAKDalam pelaksanaan pembangunan suatu proyek konstruksi, terdapat tiga unsur utama yaitu waktu yang efisien, biaya minimal dan mutu yang sesuai. Tujuan dari penelitian ini adalah menghitung perubahan biaya dan waktu pelaksanaan proyek dengan variasi lembur dan penambahan tenaga kerja. Analisis data menggunakan program Microsoft Project 2010 dan metode Time Cost Trade Off. Hasil penelitian ini menunjukkan bahwa (1) Waktu dan biaya optimum akibat lembur didapat pada umur proyek 235 hari kerja dengan total biaya proyek sebesar Rp8.438.038.832 dengan efisiensi waktu proyek sebanyak 5 hari (2,13%) dan efisiensi biaya proyek sebesar Rp3.559.695 (0,042%). (2) Waktu dan biaya optimum akibat penambahan tenaga kerja menjadi pilihan terbaik dengan hasil yang didapat pada umur proyek 226 hari kerja dengan total biaya proyek sebesar Rp8.429.832.759 dengan efisiensi waktu proyek sebanyak 14 hari (6,19%) dan efisiensi biaya proyek sebesar Rp11.779.674 (0,14%).
Designing of english challenge mobile game application as the media of english language learning
Authors: Setyadharma Vito Pratama Putra , Iryanti Emi , Hidayatulloh Indra , Nugraha Novanda Alim Setya 
Published: June 2021

English became the first foreign language that came to Indonesia in 1967. The human needs of English can already be seen through lots of official scientific works in English and its intense competitions globally. However, still, many people finds it difficult to learn English, for example, the difficulty in understanding tenses, differences between writing, reading and pronouncing. By relying on the latest features on smartphone, which on the mean time, smartphone is one of many gadgets that is the most practical to use in anywhere and anytime, plus, with gaming contents as the best multimedia entertainer application, learning English will be more interactive and easier to use. In this research, Construct 2 is used as The Developer App and Game Development Life Cycle (GDLC) method of Rido Ramadan and Yani Widyani’s version is used as The Development Method. The game system tested by using black box and by giving out Questionnaire for User Interface Satisfaction to 24 respondents, to test the system’s usability. It resulted 80,83% for the whole of the system, meaning that the whole system is quiet interesting in the respondents’s view. Then, the screen display gained 80,41%, this means that the screen display is very interesting and did not confuse the respondents. Technology and information game gained 75,41%, this means that the information contained in the game is quiet good, however, further development is needed. The introduction of the game’s system gained 71,63%, means that some of the system’s ability did not run effectively and needed further repairment and development. The last, usability and user interface gained 76,25%, this means that the game is quiet interactive to the respondents.
The Influence of Problem-Based Learning and Direct Teaching on Students’ Learning Outcomes
Authors: Raharjo Heru , Khairudin M. , Baser Jamil Abd 
Published: June 2021

One of the student-centered learning methods which is able to improve the students’ learning outcomes is Problem-Based Learning (PBL). This study examined (1) the difference in the learning results of students using PBL and Direct Teaching (DT) with high and low learning motivation and creativity, (2) the influence of learning methods with motivation and creativity toward learning outcomes, and (3) the difference in the learning results of students using PBL and DT in terms of learning motivation and creativity. The subject consisted of students of Vocational High Schools or Sekolah Menengah Kejuruan N 1 Ngawen. The data analysis used an ANOVA test and a T-test. The results revealed (1) insignificantly different learning outcomes between the use of PBL and DT, (2) insignificantly different learning outcomes with the significance of 0.652 between students with high and low motivation, (3) significantly different learning outcomes with the significance of 0.039 between students with high and low creativity, (4) influence of the interaction between learning methods with learning motivation to the learning outcomes, (5) influence of the interaction between learning methods with creativity to the learning outcomes, (6) insignificantly different learning outcomes between students using PBL and DT in terms of learning motivation, and (7) insignificantly different learning outcomes between students using PBL and DT in terms of creativity.
Learning Outcomes Mapping of the Three Year-Electronic Engineering Diploma in Level-5 Professional Expertise of the National Qualification Framework
Authors: Handayani Peni , Putro Trisno Yuwono , Rakhman Edi , -Ching Su Jo 
Published: June 2021

The issue of enhancing national competitiveness, in ASEAN, has been strengthened since the establishment of ASEAN Economic Community in 2015. The recognition of graduate competence becomes very crucial for this era. Polytechnic as vocational higher education needs to prepare its graduates in order to compete in the job market, such as through professional certification. This study aimed at mapping the learning outcomes among graduates of the three year - diploma in Electronic Engineering in Polytechnic of Instrumentation and Electronic Control System on professional qualification based on level-5 Indonesian National Qualifications Framework Curriculum and Indonesia Industrial Standard Classification 2015. This study used a qualitative method. Data were collected through observation and interviews of the competent persons to provide related research data. The results showed that the learning outcomes of the three year diploma in Electronic Engineering were suitable for the work of the services and processing industry category. This map can be used to develop learning outcomes into a professional competence for a particular job in accordance with the qualifications of the graduate program.
Implementation of a Raspberry Pi Trainer for the Subject of Microprocessors and Microcontrollers in Vocational High Schools
Authors: Juanda Enjang Akhmad , Wahidah Nurul , Khairudin M. , Mohamed Z. 
Published: June 2021

A Raspberry Pi Trainer is a tool which is able to support and facilitate the learning process of the subject of microprocessors and microcontrollers. The objective of this study was to find out the process and the results of the implementation of a Raspberry Pi Trainer for the subject of microprocessors and microcontrollers in the expertise program of industrial electronics in vocational high schools. This study used a qualitative method. The descriptive data were resulted from the observed students’ behavior in the form of the research informants’ activities covering the domains of cognitive, psychomotor, and affective. There were 20 informants divided into two classes, 10 in class XII A and 10 in class XII B. Each class consisted of 2 males and 8 females. The results showed the Raspberry Pi Trainer was well applied in practical learning activities. The average abilities of class XII B and class XII A for the domains of cognitive, psychomotor and affective were categorized as very good, good and moderate respectively.