bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbidity in children with gallstone disease
Authors: Matalaeva S. Yu. , Shashel V. A. 
Published: March 2021

According to the WHO report, in 44.0% of cases of the adult population, comorbidity is formed, which increases with the age of the patients. Meanwhile, early detection and impact on a single etiopathogenetic mechanism of comorbid diseases will not only reduce the number of diseases in one and the same patient, but also help solve the problem of polyprogmasia and disability of patients. In pediatric practice, there are isolated works devoted to the problem of comorbidity, in connection with which our studies on the study of comorbid conditions in children with cholelithiasis (cholelithiasis) are of particular interest.Purpose. The aim of this study was to improve the early diagnosis of comorbid diseases in children with cholelithiasis for the development of therapeutic and prophylactic measures and rehabilitation of patients with cholelithiasis.Material and methods. This study involved 146 children with cholelithiasis (GSD), selected based on the results of appeals to the consultative-polyclinic and inpatient departments of the State Budgetary Healthcare Institution of the Children’s Regional Clinical Hospital of Krasnodar. Children were divided into three groups according to the number of comorbid diseases. Group I consisted of 59 children, including 38 girls (26.0%) and 21 boys (14.4%), whose average age was 8.6 ± 4.5 years, with 3 comorbid diseases. Group II — 57 children, (29–19.7% girls and 28–19.2% boys, average age was 9.1 ± 4.4 years, with 5 comorbid diseases. Group III — 30 children (14–9.6% of girls and 16–11.0% of boys), the average age was 10.3 ± 4.7 years with 6 or more comorbid diseases.The clinical trial protocol was approved at a meeting of the ethnic committee of the KubSMU, Krasnodar.Conclusion. Comorbidity in children with gallstone disease is common. Among them, functional disorders of the biliary tract are in the lead. Among chronic diseases of the digestive tract, diseases of the upper sections of the digestive tract are significantly more common, and somewhat less often of the liver and pancreas. More than half of children with gallstones have comorbidity of other organs and systems, in particular, diseases of the upper respiratory tract and urinary system are more often determined. Comorbid diseases increase the severity of the condition and worsen the prognosis of the disease. Diagnosis of comorbid conditions should be thorough in order to select adequate therapy, taking into account the combination of drugs. At the same time, the environment is one of the risk factors for the development of children with gallstone disease.
Karakterisasi Abu Dasar Batubara Termodifikasi 8-Hidroksikuinolin sebagai Adsorben Ion Logam Cu(II) dan Cd(II)
Authors: Agusriyadin Agusriyadin 
Published: March 2021

Telah dilakukan penelitian tentang adsorpsi ion Cu(II) dan Cd(II) menggunakan abu dasar batubara teraktivasi (ADT) dan abu dasar batubara termodifikasi 8-hidroksikuinolin (ADO). Penelitian ini bertujuan untuk mempelajari kemampuan ADT dan ADO dalam mengadsorpsi ion logam Cu(II) dan Cd(II). Karakterisasi adsorben dilakukan menggunakan SEM-EDS untuk mengamati morfologi/kenampakan permukaan adsorben serta mengidentifikasi komponen kimia unsur-unsur penyusun abu dasar, Fourier Transform Infrared (FTIR) untuk mengidentifikasi gugus fungsi yang terdapat pada adsorben, X-ray diffraction (XRD) untuk melihat perubahan kristalinitas mineral penyusun adsorben, dan Gas Sorption Analyzer (GSA) untuk menentukan sifat pori adsorben seperti ukuran diameter, luas permukaan, distribusi ukuran pori, dan volume pori dari adsorben yang digunakan. Karakterisasi ini dilakukan sebelum dan sesudah adsorpsi. Hasil penelitian menunjukkan bahwa pH optimum semua kondisi perlakuan tercapai pada pH 6 dengan kapasitas adsorpsi ADQ terhadap logam Cu(II) dan Cd(II) masing-masing 24, 64 mg.g-1 dan 22,50 mg.g-1. Kapasitas adsorpsi ADQ selalu lebih tinggi dibandingkan ADT. Afinitas adsorpsi ion logam Cu(II) juga lebih baik dibandingkan ion Cd(II) terhadap kedua adsorben.
PENYULUHAN PENGELOLAAN PROGRAM DAN IMPLEMENTASI LEMBAGA DAKWAH MAJELIS TA'LIM IHYA AS-SUNNAH DI KECAMATAN SUKAJADI KOTA BANDUNG JAWA BARAT
Authors: Daryanti Neirna Yayah , Elhany Hemlan 
Published: March 2021

Dari hasil pengkajian mengenai kepengurusan dalam majlis ta’lim sebagai tempat untuk membentuk karakter seseorang dan dari pendidikan sendiri menjadi acuan bagi warga sukajadi dalam mengamalkan setiap ajaran yang sudah diberikan. Toleransi terhadap majlis yang diadakan didaerah tersebut sangat dihormati dan juga diterima dengan baik. Dan tokoh Ihya As-Sunnah menjadi salah satu orang yang berpengaruh dalam aspek keagamaan serta kemasyarakatan di lingkungan sukajadi.
Dalam pengelolaan kepengurusan majlis ta’lim Ihya As-Sunnah baru sampai tahapan rancangan, pengorganisasian kegiatan, pembinaan yang diberikan, dan juga pengawasan . Kemudian dalam pengorganisasian kegiatan belum dijalankan dengan semaksimal mungkin, karena dalam sebuah kegiatan organisasi haruslah adanya partisipasi masyarakat tersebut, jangan sampai berhenti ditengah jalan.
Motivasi yang dijalankan oleh pihak majelis hanyalah sebuah masukan, atau menghimbau terhadap para pengelola dan juga jamaah. Terkadang juga pengendalian yang dijalankan oleh pihak majlis belum terlaksana dengan baik.
- Analisis Pengaruh Pemberian Motivasi Terhadap Kinerja Karyawan di PT. Bank Syariah Mandiri Cabang Panyabungan
Authors: Ian Ian Alfian 
Published: March 2021

ABSTRAK
Penelitian yang dilakukan bertujuan untuk mengetahui pengaruh pemberian motivasi terhadap kinerja karyawan di PT Bank Syariah Mandiri Cabang Panyabungan. Metode yang digunakan dengan pendekatan kuantitatif. Hasil penelitian bahwa pemberian motivasi berpengaruh signifikan terhadap kinerja karyawan di PT Bank Syariah Mandiri Cabang Panyabungan. Hal tersebut dapat dilihat dari uji hipotesis dimana koefisien determinasi (R2) menunjukkan sebesar 0.714 atau 71.4%, artinya bahwa variabel kinerja dapat diterangkan oleh variabel motivasi sebesar 71.4% sedangkan sisanya 28.6% diterangkan oleh variabel lain diluar penelitian. Pada uji t diperoleh thitung sebesar 5.469. artinya thitung (5.469) > ttabel (1.782) dan Pvalue (0.00) < α (0.05), artinya Ha diterima dan H0 ditolak. Sedangkan model regresi yang terbentuk menyatakan bahwa motivasi memberikan pengaruh yang signifikan terhadap kinerja dengan koefisien 1.004 yang berarti bahwa jika motivasi yang diberikan sebanyak 1 kali maka kinerja akan naik sebesar 1.004.
Kata Kunci: Motivasi, Kinerja, Karyawan
PENGARUH LINGKUNGAN KERJA, PENGHARGAAN (REWARD) DAN PUNISHMENT TERHADAP KINERJA KARYAWAN (Studi Kasus Pada Pt. Socfhindo Divisi IV Afdheling Seleleh)
Authors: Kamal Safwan 
Published: March 2021

Lingkungan kerja, penghargaan (reward) dan punishment merupakan faktor yang penting untuk menunjang kinerja sekaligus memberi dorongan bagi karyawan untuk meningkatkan semangat dalam bekerja. Penelitian ini bertujuan untuk mengetahui pengaruh lingkungan kerja, penghargaan (reward) dan punishment terhadap kinerja karyawan. Penelitian ini menggunakan penarikan sampel probability sampling dan menentukan jumlah sampel dari suatu populasi menggunakan simple random sampling dimana setiap anggota populasi mempunyai peluang yang sama untuk dipilih menjadi anggota sampel berdasarkan kriteria tertentu sesuai dengan kriteria yang dilakukan peneliti. Sampel yang ditentukan yaitu 63 responden. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh lingkungan kerja yang positif dan signifikan terhadap kinerja karyawan dilihat dari nilai (t hitung) 2,696 > 2,00100 (t tabel) dengan tingkat sig. 0.003 < 0,05. Variabel penghargaan (reward) berpengaruh positif dan signifikan terhadap kinerja karyawan yang dilihat dari nilai (t hitung) 3,257 > 2,00100 (t tabel) dengan tingkat sig. 0.002 < 0.05. Variabel punishment berpengaruh positif dan signifikan terhadap kinerja karyawan yang dilihat dari nilai (t hitung) 3,638 > 2,00100 (t tabel) dengan tingkat sig. 0.004 < 0.05. terdapat pengaruh secara simultan antara lingkungan kerja, penghargaan (reward) dan punishment hal ini dilihat dari F hitung (5,122) lebih besar dari F tabel (2,76) dengan tingkat signifikan 0.003 < 0,05.
The Securing Nest Behavior of Changeable Hawk-Eagle : A case study at Educational Forest of Forestry Faculty of Mulawarman University
Authors: Boer Chandradewana , Ridwan Ridwan , Prasetya Ari 
Published: March 2021

This study aims to determine the nest funding and behaviour of Changeable Hawk-eagle (Nisaetus cirrhatus). The research was carried out at the Forest for Education of Forestry Faculty of Mulawarman University. The result showed that the male hawk watched the nest more than female during the breeding season. Furthermore, drones were used to obtain the position of the eggs due to the high nest tree.
Equating Villa with Theft Offense"House" in Aggravated
Authors: Setiawan Peter Jeremiah , Nugraha Xavier , Wibowo Widyanti 
Published: March 2021

One of the places that is often targeted by thieves is in a villa. In Article 363 paragraph (1) 3 of the Criminal Code, there is a regulation related to theft with a aggravating if the theft is carried out at night in a house or closed yard where the house is, but there is no provision that explicitly states that it is related to theft in a villa. Based on this background, the formulation of the objectives of this article is to understand: 1. What are the elements of the aggravated theft offense ? 2. Can a villa be conaidered with a "house" as an element of the aggravated theft offense ? This research is a normative legal research with statutory, conceptual, and case approaches. Based on the analysis in this article, it can be understood that 1. The elements in the offense are the same as ordinary theft, but there are additional elements that are alternative. 2. The theft in a villa at night can be qualified for theft with a aggravating factor as stipulated in Article 363 paragraph (1) of the Criminal Code, on the basis of socio-historical interpretation and extensive interpretation
Spontaneous healing response of oblique root fracture: case report with 4-year follow-up
Authors: Bastos Hugo José Santos , Pereira Key Fabiano Souza , Tomazinho Luiz Fernando , Frozoni Marcos Roberto dos Santos , Mendes Élida Boaventura 
Published: March 2021

Root fractures can involve the dentin, cementum, and pulp and commonly can occur as oblique fractures with varying orientations. The aim of this study was to demonstrate the maintenance of pulp health in a tooth with a fractured root without any endodontic treatment and to discuss the advantage of cone-bean computed tomography (CBCT) compared with traditional radiographs in the diagnosis of oblique root fractures. Intra-oral radiography of tooth 11 revealed a horizontal root fracture at the level of the apical third, while the sagittal CBCT slice reveals a complete fracture line running obliquely from the apical third on the buccal aspect through the cervical third on the palatal aspect. Four years follow-up, the tooth has kept its pulp vitality, no tooth discoloration or discrepancy in arch position, without endodontic treatment. This result illustrates spontaneous healing of root fracture including preservation of pulp health. In addition, it confirms the importance of exams in 3 dimensions to correctly locate the fracture and assist in the treatment decision.
Revisão do uso medicinal de Rhaphiodon echinus Schauer (Lamiaceae): Atividades biológica e farmacológica
Authors: Cruz Neto João , Viana José Wellington Macêdo , Silva Viviane Bezerra da , Costa Adrielle Rodrigues , Costa Maria Haiele Nogueira da , Santos Marcos Aurélio Figueiredo dos , Rodrigues Joice Layanne Guimarães , Teixeira Pedro Hudson Rodrigues , Oliveira João Paulo Camilo de , Correia Dennis Bezerra , Menezes Saulo Almeida de , Santos Luciano Temoteo dos , Oliveira Maraiza Gregorio de , Silva Junior João Pereira da , Gurgel Catarina Leite , Sampaio Raimundo Samuel Leite , Lima Junior Fernandes de , Araújo Nara Juliana Santos , Almeida-Bezerra José Weverton 
Published: March 2021

Objetivou-se realizar uma revisão bibliográfica acerca das atividades biológica e farmacológica de Rhaphiodon echinus. Trata-se de uma revisão integrativa norteada pela seguinte pergunta: Quais as evidências cientificas acerca da atividade biológica e farmacológica da R. echinus? Elegeu-se as bases: MEDLINE, PUBMED, BDENF, SCOPUS e WoS para a pesquisa. Foi identificada uma população de 54 estudos cuja amostra caracterizou-se por nove artigos. Suscita-se que óleo essencial e os extratos etanólico e aquoso de R. echinus possuem compostos químicos de relevância em testes fitoquímicos e farmacológicos, demonstrando atividades antioxidantes e anti-inflamatória, além de atividade antimicrobiana contra Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa ao potencializar a ação de fármacos como gentamicina e ciprofloxacino, assim como atividade antifúngica contra Candida albicans. Ademais, a atividade fitoterápica de R. echinus em chás, xaropes e banhos é observada contra inflamação uterina, gripe, cólica intestinal e infecção do trato urinário. Em suma, ressalta-se que são necessários novos estudos envolvendo R. echinus na área de etnobotânica a fim de melhor entender sua utilização e interfaces com o saber popular com vistas ao seu uso na prática clínica.
Walking with John Howard: Itineracy and Romantic Reform
Authors: Cervantes Gabriel , Porter Dahlia 
Published: March 2021

This essay identifies a new source for the politicization of walking in the final decades of the eighteenth century, John Howard's The State of the Prisons (1777). Howard made a case for reforming prisons in Britain and across Europe based on evidence collected on his wide-ranging travels, during which he made a practice of stepping into spaces of incarceration where others – including jailors themselves – refused to tread. As we show, Howard was celebrated for the seemingly global reach of his humanitarian mission, but in the work of poets and biographers he also became an icon for the levelling potential of walking into spaces occupied by the legally, socially and economically disenfranchised. Howard's text, however, presents a tension between asserting common humanity with prisoners and exercising patrician benevolence. As we show in conclusion, this tension persists in early nineteenth-century literary representations of both prison reform and walking by Wordsworth and De Quincey, whose texts trouble the (by then established) assumption that walking constituted a politically radical act of social levelling.
Quality of Maternal Death Documentation in Afghanistan: A Retrospective Health Facility Record Review
Authors: Maruf Farzana , Tappis Hannah , Stekelenburg Jelle , van den Akker Thomas 
Published: March 2021

Objectives: To assess the quality of health facility documentation related to maternal deaths at health facilities in Afghanistan.Methods: Analysis of a subset of findings from the 2016 National Maternal and Newborn Health Quality of Care Assessment in Afghanistan. At each facility, maternity registers were reviewed to obtain data related to maternity caseload, and number and causes of maternal deaths in the year preceding the survey. Detailed chart reviews were conducted for up to three maternal deaths per facility. Analyses included completeness of charts, quality of documentation, and cause of death using WHO application of International Statistical Classification of Disease to deaths during pregnancy, childbirth and the puerperium.Key findings: Only 129/226 (57%) of facilities had mortality registers available for review on the day of assessment and 41/226 (18%) had charts documenting maternal deaths during the previous year. We reviewed 68 maternal death cases from the 41 facilities. Cause of death was not recorded in nearly half of maternal death cases reviewed. Information regarding mode of birth was missing in over half of the charts, and one third did not capture gestational age at time of death. Hypertensive disorders of pregnancy and obstetric hemorrhage were the most common direct causes of death, followed by maternal sepsis and unanticipated complications of clinical management including anesthesia-related complications. Documented indirect causes of maternal deaths were anemia, cardiac arrest, kidney and hepatic failure. Charts revealed at least eight maternal deaths from indirect causes that were not captured in register books, indicating omission or misclassification of registered deaths.Conclusion: Considerable gaps in quality of recordkeeping exist in Afghanistan, including underreporting, misclassification and incompleteness. This hampers efforts to improve quality of maternal and newborn health data and priority setting.
Nasopharyngeal Microbial Communities of Patients Infected With SARS-CoV-2 That Developed COVID-19
Authors: Ventero Maria Paz , Cuadrat Rafael R. C. , Vidal Inmaculada , Andrade Bruno G. N. , Molina-Pardines Carmen , Haro-Moreno Jose M. , Coutinho Felipe H. , Merino Esperanza , Regitano Luciana C. A. , Silveira Cynthia B. , Afli Haithem , López-Pérez Mario , Rodríguez Juan Carlos 
Published: March 2021

BackgroundSARS-CoV-2 is an RNA virus causing COVID-19. The clinical characteristics and epidemiology of COVID-19 have been extensively investigated, however, only one study so far focused on the patient’s nasopharynx microbiota. In this study we investigated the nasopharynx microbial community of patients that developed different severity levels of COVID-19. We performed 16S ribosomal DNA sequencing from nasopharyngeal swab samples obtained from SARS-CoV-2 positive (56) and negative (18) patients in the province of Alicante (Spain) in their first visit to the hospital. Positive SARS-CoV-2 patients were observed and later categorized in mild (symptomatic without hospitalization), moderate (hospitalization), and severe (admission to ICU). We compared the microbiota diversity and OTU composition among severity groups and built bacterial co-abundance networks for each group.ResultsStatistical analysis indicated differences in the nasopharyngeal microbiome of COVID19 patients. 62 OTUs were found exclusively in SARS-CoV-2 positive patients, mostly classified as members of the phylum Bacteroidota (18) and Firmicutes (25). OTUs classified as Prevotella were found to be significantly more abundant in patients that developed more severe COVID-19. Furthermore, co-abundance analysis indicated a loss of network complexity among samples from patients that later developed more severe symptoms.ConclusionOur study shows that the nasopharyngeal microbiome of COVID-19 patients showed differences in the composition of specific OTUs and complexity of co-abundance networks. Taxa with differential abundances among groups could serve as biomarkers for COVID-19 severity. Nevertheless, further studies with larger sample sizes should be conducted to validate these results.
Prognostic Value of Various Hemostasis Parameters and Neurophysiological Examinations in Spontaneous Intracerebral Hemorrhage: The IRONHEART Study Protocol
Authors: Árokszállási Tamás , Héja Máté , Bagoly Zsuzsa , Kovács Kitti Bernadett , Orbán-Kálmándi Rita , Sarkady Ferenc , Tóth Judit , Fekete Klára , Fekete István , Csiba László 
Published: March 2021

Rationale: Stroke is one of the leading causes of death in all developed countries. In Hungary, more than 10,000 patients die annually due to cerebrovascular diseases according to the WHO Mortality Database. Of these patients, 10–15 % suffer non-traumatic intracerebral hemorrhage (ICH). ICH results in a higher rate of mortality as compared to ischemic stroke and outcomes are difficult to predict. In the IRONHEART study, we aim to test various hemostasis parameters and clinical neurophysiological examinations in evaluating outcome in ICH.Methods: In this prospective, observational study, we plan to enroll consecutive patients with non-traumatic spontaneous ICH admitted to a single Stroke Center (Department of Neurology, University of Debrecen, Hungary). The protocol of the IRONHEART study includes the investigation of detailed clinical, laboratory investigations, and various neurophysiological examinations. Stroke severity is quantified based on the National Institutes of Health Stroke Scale (NIHSS) on admission and day 7, 14, and 90 after the onset of stroke. Cranial CT is performed on admission, day 14, and 90 to estimate the ICH volume. Modified Rankin Scale (mRS) is used for evaluating the long-term outcome (90 days post-event). Blood is drawn immediately on admission for specific hemostasis tests. Digital and quantitative EEG techniques and motor evoked potential (MEP) are performed to evaluate the prognosis of cerebral hemorrhage on admission (within 24–48 h), immediately before discharge (~10–14 days later), and 3 months after the event.Outcomes: The following outcomes are investigated: primary outcomes: mortality by day 14 and day 90, secondary long-term outcome at 90 days post-event where mRS 0–2 is defined as favorable long-term outcome.Discussion: If associations between outcomes and the investigated parameters (hemostasis and neurophysiological examinations) are confirmed, results might aid prognosis assessment in this subtype of stroke with particularly high mortality. Improving clinical grading systems on ICH severity and outcomes by including the investigated parameters could help to better guide the management of these patients in the future.
In Comparison to PSA, Interim Ga-68-PSMA PET/CT Response Evaluation Based on Modified RECIST 1.1 After 2nd Cycle Is Better Predictor of Overall Survival of Prostate Cancer Patients Treated With 177Lu-PSMA
Authors: Prasad Vikas , Huang Kai , Prasad Sonal , Makowski Marcus R. , Czech Norbert , Brenner Winfried 
Published: March 2021

BackgroundProstate-specific membrane antigen (PSMA) targeting radioligands have transformed treatment of prostate cancer. Radioligand therapy (RLT) with 177Lu-PSMA in metastasized castration resistant prostate cancer (mCRPC) achieves objective response and disease stabilization in roughly two third of patients, whereas one third of patients progress. This study was performed to assess the role of interim PSMA PET/CT after the 2nd cycle of RLT for early prediction of overall survival in patients undergoing RLT with 177Lu-PSMA.Methods38 mCRPC patients (68.9 ± 8.1 y) treated with at least two cycles of RLT at 8 week intervals and interim 68Ga-PSMA PET/CT (PET) at 8–10 weeks after the 2nd cycle of RLT were included in this study. Prostate-specific antigen (PSA) response was evaluated according to the Prostate Cancer Working Group 3 criteria. Radiographic response assessment of soft tissue, lymph node, and bone lesions was performed according to RECIST 1.1 including the PET component. Patients’ data were collected for follow-up from the local Comprehensive Cancer Center Register.ResultsMedian follow-up was 19.7 months (4.7–45.3). PSA response after the 2nd therapy cycle showed partial remission (PR) in 23.7%, stable disease (SD) in 50%, and progressive disease (PD) in 26.3% of patients. In comparison, 52.6, 23.7, and 23.7% of patients showed PR, SD, and PD respectively on PET/CT. The strength of agreement between PSA response and PET/CT response criteria was only fair (kappa 0.346). Median overall survival (OS) was 22.5 months (95% CI: 15.8–29.2). Median OS stratified to PSA/PET response was 25.6/25.6 months for PR, 21.7/30.6 months for SD and 19.4/13.1 months for PD (p = 0.496 for PSA and 0.013 for PET/CT response).ConclusionsInterim PSMA PET/CT based response evaluation at 8–10 weeks after the 2nd cycle of RLT is predictive of overall survival and PD in patients treated with 177Lu-PSMA. On the contrary, PSA appears to have only limited predictive value.