bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggressive sinonasal angiomyxoma management with endoscopic medial maxillectomy approach: a rare case report
Authors: Thamrin Mohammad Husni , Sutikno Budi 
Published: January 2025

Link of Video Abstract: https://youtu.be/SNbUkDVumjI

Background: Aggressive angiomyxoma is a benign tumour of mesenchymal origin, and its incidence is very rare. The treatment of choice for aggressive sinonasal angiomyxoma is surgical extirpation based on the location of the tumour. The surgical procedure can be performed endoscopically or externally. This study aims to report the management of an aggressive sinonasal angiomyxoma rare case with an endoscopic approach.
Case presentation: A 20-year-old female came with the chief complaint of a blocked right nose for the past six months. Patients often had varying amounts of intermittent epistaxis from the right nose, which could stop by itself but in a longer time. Three studies met the inclusion criteria and stated that aggressive sinonasal angiomyxoma is rare. Extirpation surgery was performed with an endoscopic medial maxillectomy approach. Histopathology showed a benign mesenchymal cell tumour consistent with angiomyxoma.
Conclusion: The sinonasal tumour with an early preoperative diagnosis of an antrochoanal polyp and a postoperative diagnosis of an aggressive sinonasal angiomyxoma underwent extirpation surgery with an endoscopic medial maxillectomy approach results in no recurrences after two years.
Effectivity and safety profile of oxalate decarboxylase in hyperoxaluria patient: A meta-analysis and systematic review
Authors: Rodjani Arry , Putra Christian Nurtanto , Raharja Putu Angga Risky , Widia Fina , Situmorang Gerhard Reinaldi , Rahardjo Harrina Erlianti , Wahyudi Irfan 
Published: January 2025

Link of Video Abstract: https://youtu.be/BNXqnQcXK8U

Introduction: The high incidence of urinary stones leads to many related medical issues and substantial financial burdens. In addition to treatment interventions, executing preventive measures is crucial in reducing the likelihood of kidney stone recurrence. Oxalate decarboxylase is now being developed as a preventive measure for treating hyperoxaluria, a risk factor for stone formation. This study aims to evaluate the efficacy and safety of oxalate decarboxylase in treating hyperoxaluria.
Methods: A comprehensive review of the existing literature was performed by conducting a systematic search across various databases, including Cochrane Library, Google Scholar, PubMed, and Embase. The mean difference (MD) of 24-hour urinary oxalate excretion from baseline to treatment was assessed in each study. Cochrane Collaboration’s Review Manager 5.4.1 software was used for statistical analysis, and RoB 2 tools were used for bias risk assessment.
Result: Five studies that satisfied the specified criteria were included in the analysis, 3 of which were analyzed for meta-analysis data, while the other for systematic review. Meta-analysis showed that oxalate decarboxylase had a statistically significant efficacy compared to placebo in reducing oxaluria with MD of 9,72 mg/day (95% CI 7,43 to 12,10). Regarding safety, there is not much difference in the number of complications between oxalate decarboxylase and placebo, with only one study reporting a serious adverse event (SAE) of sacral radiculopathy in the intervention group.
Conclusion: Oxalate decarboxylase is a potential and promising alternative treatment for reducing urinary oxalate levels in hyperoxaluria patients. Therefore, it can be regarded as a viable choice in pharmacological treatment for preventing the occurrence of oxalate stones in patients in the future.
Management of abdominal pregnancy with placenta left in situ
Authors: Indrayanti Sofiana , Hanifa Erlin Dharmayanti  , Muhammad Yusuf  , Ernawati  
Published: January 2025

Introduction: Abdominal pregnancy is a rare form of ectopic pregnancy with a challenging diagnosis and management. We reported two cases of abdominal pregnancy with the placenta left in situ, which had different outcomes.
Case Presentation: Case one was a woman (P1A1) referred due to active bleeding after an emergency laparotomy for advanced abdominal pregnancy (36–37 weeks gestational age [GA]). The newborn (3300 g) was delivered alive, but the placenta was left in situ due to hemodynamic instability. Re-exploration surgery revealed a placenta in the abdominal cavity, covering the caecum and ileocaecal junction. The placenta was left due to high suspicion of infiltration into the retroperitoneum and hemodynamic instability. Serial β-hCG levels declined progressively but increased again at day 48. A methotrexate regimen (20 mg/day) for five days was given, and the level was 6.03 mIU/ml on day 94. However, the abdominal wound was still seeping even after 12 months post-operatively due to suspicion of fistula formation. The placenta was fully absorbed after 14 months post-operative.
Case two was a woman (G2P1) referred due to ectopic pregnancy and fetal demise at 14-15 weeks GA. Emergency laparotomy revealed abdominal pregnancy. The placenta was also left intra-abdominal due to active bleeding in the implantation area. The serial β-hCG declined progressively, with no neovascularization, and the placenta was fully absorbed four months and six months after the operation, respectively.
Conclusion: In managing abdominal pregnancy with placenta left in situ, periodic quantitative β-hCG, ultrasound examination of the placental size, and monitoring of surgical wounds are indispensable. Chemotherapy must be initiated if there is a plateau or an increase of serial β-hCG level or neovascularization of placental Doppler.
Sarcopenia as an indicator of nutritional status and predictor of upper gastrointestinal cancer mortality at Dr. Sardjito Central Hospital
Authors: Prawirohardjo Arif Nurhidayat , Handaya Adeodatus Yuda , Setyawan Nurcahya , Utomo Bambang Purwanto 
Published: January 2025

Link of Video Abstract: https://youtu.be/JUvgQGPXblo

Background: Sarcopenia is defined as a musculoskeletal disease generally characterized by loss of skeletal muscle mass, skeletal muscle strength, and physical performance. This study aims to determine sarcopenia as an indicator of nutritional status and predictor of mortality among patients with upper gastrointestinal cancer at Dr. Sardjito Hospital.
Methods: This study is a cross-sectional study using secondary data in medical records conducted from April to May 2023 at Dr. Sardjito Hospital Yogyakarta. The sample consisted of 32 patients and reached the inclusion & exclusion criteria. The data were subsequently analyzed through bivariate analysis with the Chi-Square test. Data were analyzed using SPSS version 25.0 for Windows.
Results: From the 32 study samples obtained, 81.3% had sarcopenia while the remaining 18.8% did not have sarcopenia; 31.3% of patients were categorized as underweight, 50% of patients were normal, and 18.8% of patients were overweight; and 59.4% of patients died while the remaining 40.6% lived. No significant association was found between sarcopenia and nutritional status (p=0.169). However, a significant association was observed between sarcopenia and mortality (p=0.029), with an odds ratio of 0.089.
Conclusion: Sarcopenia cannot be used as an indicator of the nutritional status of upper gastrointestinal cancer patients. However, it can serve as a predictor for mortality associated with the disease.
Molecular characterization and the virulence gene presence of uropathogenic Escherichia coli in the Indonesian community: the phylogeny groups and clinical manifestation
Authors: Suwarsono Erike Angggraini , Soebandrio Amin , Karuniawati Anis , Bela Budiman , Shahab Nouval , Lie Khie Chen , Rosana Yeva , Arozal Wawaimuli , Prihantono Joedo 
Published: January 2025

Link of Video Abstract: https://youtu.be/X3877wT108E

Background: Uropathogenic Escherichia coli (UPEC) is the most prevalent pathogen in Community-acquired Urinary Tract infections (Ca-UTI) with a divergent spectrum of clinical diseases. Molecular characterization of the virulence gene and the phylogeny group of UPEC could elucidate the broad spectrum of clinical manifestations associated with this pathogen, ranging from asymptomatic bacteriuria to urosepsis.
Method: This study collected clean catch urine samples from Ca-UTI patients between 2019 and 2020. The urine sample was inoculated onto blood sheep and MacConkey agar and incubated overnight. A colony was selected for phenotypic and antimicrobial sensitivity testing using Vitex2. All isolates identified as E.coli were validated by the 16S specific gene of E.coli using Taqman real-time PCR. Furthermore, virulence genes fimH, sfaS, pap C, cnf-1, and hlyA were identified using real-time PCR, followed by a phylogeny group, according to Clermont. All those data were analyzed descriptively.
Results: This study involved the collection of 188 urine samples from patients with Ca-UTI, and 54 isolates were confirmed to be true E.coli, and the B2 phylogeny group was observed to be the most dominant in cystitis (42%) and pyelonephritis (73%). However, groups A and B1 didn’t appear in pyelonephritis patients. Both sfaS and hly-A were virulence genes detected in the B2 and D groups. Gene fimH that encoded adherence factor was seen in all phylogeny groups.
Conclusions: Based on the result, it can be concluded that B2 is the dominant phylogeny group in Ca-UTI, sfaS and hlyA is a virulence gene responsible for pyelonephritis, and fimH is the adherence factor in all isolates.
Abdominal tuberculosis with multi-organ involvement in CT imaging: a unique and rare case report
Authors: Amalia Puri Handayani  , Muhammad Hidayat Surya Atmaja  
Published: January 2025

Link of Video Abstract: https://youtu.be/T1AM2QgdclM

Background: Abdominal tuberculosis, accounting for 5% of global cases, is one of the most common forms of extrapulmonary tuberculosis. It can affect various parts of the abdomen, single or multi-organ involvement. Accurately identifying the proper diagnosis poses a significant challenge due to the wide range of clinical and radiological manifestations that resemble other diseases, potentially leading to treatment delays. In this case report, we present a sporadic and particular case of abdominal tuberculosis with multi-organ involvement, highlighting key CT imaging features for diagnosis.
Case Presentation: A sixteen-year-old girl presented to our center with a distended abdomen and a growing lump in the left waist that had been progressing for three months, anorexia, and weight loss. CT scan examination showed abdominal tuberculosis with multi-organ involvement, with unique and rare features of tuberculous peritonitis, tuberculous lymphadenitis, tuberculous hepatosplenic, and tuberculous retroperitoneal abscess. CT scan findings in abdominal tuberculosis have a classification for each organ involvement to aid in concluding the disease. Several findings, such as mesenteric cysts, calcified subcapsular hepatic nodules, splenic microabscesses, and retroperitoneal abscesses with osteoarticular involvement, are unique and rare findings in abdominal tuberculosis.
Conclusion: CT scan holds a substantial role in interpreting and diagnosing abdominal organ involvement in tuberculosis, and with mandatory proper understanding in discerning all findings, leading physicians in making decisions regarding patient management.
Immediate effects of gait biofeedback on peak plantar pressure in patients with type 2 diabetes mellitus with diabetic neuropathy
Authors: Prasetyanto Ingrid Melinda , Pawana I Putu Alit , Arfianti Lydia , Utomo Budi 
Published: January 2025

Link of Video Abstract: https://youtu.be/91dLGOg7wjc

Background: Treatment that can be done to prevent ulceration in diabetic feet is reducing high pressure in the foot area. One strategy that is currently being developed is biofeedback on gait patterns. Scientific evidence regarding the use of biofeedback in cases of diabetic neuropathy is still sparse, but it is a promising rehabilitation strategy to improve biomechanical deficits in gait patterns and allow subjects to initiate new gait strategies using visual and/or auditory information.
Methods: This study is a pre-experimental research design before and after the intervention of giving biofeedback on walking patterns to 20 subjects with diabetic neuropathy who met the inclusion criteria and did not have exclusion criteria, measured plantar pressure at the beginning of the examination, and immediately after giving biofeedback on gait patterns.
Results: The initial value of peak plantar pressure in the total area was high (more than 200 kPa). The initial value of peak plantar pressure in the 4 areas analyzed (heel, midfoot, forefoot, and big toe) was found to be in the range of 100-200 kPa, while the initial value of peak plantar pressure in the toes area was found to be <100 kPa. Immediately after administering biofeedback, the walking pattern showed a significant decrease in peak plantar pressure values in the total area, heel, and big toe compared to the initial value (p-value= 0.001, 0.012, 0.00). There was no significant decrease in peak plantar pressure values in the midfoot and toe areas.
Conclusions: A significant reduction was achieved in the average plantar pressure in the heel, big toe, and overall area. This supports the recommendation to provide walking pattern biofeedback in diabetic neuropathy patients.
Predicting bacillary load in clinically suspected pulmonary tuberculosis patients in Indonesia using Xpert MTB/RIF CT values
Authors: Sasmanto Suharyadi , Mertaniasih Ni Made , Koendhori Eko Budi 
Published: January 2025

Link of Video Abstract: https://youtu.be/EKJS5Twc8aU

Background: Smear microscopy has been employed for calculating bacillary load in pulmonary tuberculosis (TB). Nevertheless, the requirement for an innovative diagnostic approach is underscored by the limited sensitivity and specificity of smear microscopy. This study aims to investigate the interrelation of Xpert MTB/RIF CT value with AFB smear results, culture examination, and chest X-ray (CXR) findings.
Methods: This is a cross-sectional study using sputum samples from patients clinically diagnosed with pulmonary TB. Each sample underwent AFB microscopic evaluation, culture, and colony counting, as well as Xpert MTB/RIF assay. Chest X-ray results were obtained from electronic medical records. Correlations between two variables were assessed using Spearman’s test and cut-off values were determined using ROC analysis.
Results: Out of a collective 45 specimens of sputum, 80% exhibited positive AFB smear results. We found a strong correlation between each raw-CT and N-CT and positive AFB smear results (r = 0.676 and -0.650, respectively; p < 0.05). A cut off of ≤ 28.3 for raw-CT produced 91.7% sensitivity and 55.6% specificity, while > -1 for N-CT produced 77.8% and 88.9%. Moderate correlations were found between raw-CT and N-CT (r=0.412 and -0.392, respectively) and the presence of cavities on CXR, while weak correlations were found (r=0.367 and -0.385, respectively) for consolidations.
Conclusions: Positive AFB smear results in pulmonary TB correlate strongly with the Xpert MTB/RIF CT value. This put further emphasis on the utilization of Xpert MTB/RIF CT value to substitute for AFB smear as a measure of bacillary load.
Bitter Melon's fruit extract (Momordica charantia Linn.) decrease oxidative stress in hyperglycemic trophoblastic cell
Authors: Gondo Harry , Haryanti Elizabeth 
Published: January 2025

Background: Oxidative stress is a condition of imbalance between the amount of oxidants and antioxidants in the body. In preeclampsia pregnancy, hyperglycemia was known as main suspect in its pathomechanism. Bitter melon was perennial plant grown in Indonesian village and widely used traditionally as diabetic treatment. However, there is no adequate information regarding its effect in hyperglycemic pregnancy. This study aimed to determine the effect of bitter melon extract in a hyperglycemic trophoblastic cell culture.
Methods: Human placenta was obtained from the cesarean delivery process after parent consent. Isolation and culture of trophoblasts cells is carried out using enzymatic process.After confluent, trophoblastic cells was extracted and added to bitter melon extract in four groups of treatment. Administration of bitter melon fruit extract on trophoblastic cell culture in a hyperglycemic environment. After 8 hours, supernatant was collected and analyzed for superoxide dismutase and malondialdehyde. One Way Anova test was carried out to determine the significance value of the treatment of trophoblastic cell culture.
Result: The administration of bitter melon extract at a dose of 0.8 mg / ml has the highest average value of 191.6000 U/mL. This shows the effect of bitter melon extract on increasing SOD while MDA decreased by 3900.0000 U/mL which is close to the negative group. The greater the dose of bitter melon extract given, the higher the effect on SOD activity, conversely, the greater the dose of bitter melon extract given can reduce MDA activity.
Conclusion: Bitter melon fruit extract decreases oxidative stress in hyperglycemic trophoblastic cells.
relationship between allergic rhinitis and asthma in patients with rhinosinusitis
Authors: Metiananda Elvina , Hutahaean Fransiska , Panggabean Olivia 
Published: January 2025

Introduction: Allergic rhinitis and asthma are the most common diseases worldwide, and both have interconnected inflammatory processes. Allergic Rhinitis (AR), asthma, and rhinosinusitis are closely related, where patients with a history of allergic rhinitis or asthma, or even both, can develop rhinosinusitis. This study aims to determine the relationship between allergic rhinitis and asthma with rhinosinusitis at Ibnu Sina Hospital, Gresik.
Methods: Total of 300 patients were enrolled in this study. Using the total sampling method, samples were selected from the entire population of rhinosinusitis patients who received outpatient or inpatient care at the THT-KL Clinic in Ibnu Sina Hospital, Gresik, during the period 2020-2022. Secondary data extracted from the patients’ medical records at Ibnu Sina Hospital, Gresik. Subsequently, the collected data was analyzed through Spearman's correlation test and multiple linear regression analysis.
Result: Significance was found between allergic rhinitis, asthma, and rhinosinusitis, with a p-value of 0.00 and a correlation coefficient of 0.599.
Conclusion: Significant relationship has been found between allergic rhinitis and asthma with rhinosinusitis in patients with rhinosinusitis undergoing outpatient or inpatient treatment at Ibnu Sina Hospital, Gresik, during the period of 2020-2022.

Keywords: Allergic Rhinitis, Asthma, Rhinosinusitis.
The associations of personal hygiene, closed contact shoes, and high physical activities with the incidence of superficial fungal foot infections: A cross sectional study in navy military students
Authors: Hertanti Dhea Medisika , Prakoeswa Cita Rosita Sigit , Sawitri Sawitri , Hidayati Afif Nurul , Utomo Budi , Rahmadewi Rahmadewi , Sidarta Jeffrey Agung , Ervianty Evy 
Published: January 2025

Introduction: Superficial fungal foot infections is an infectious diseases resulting from dermatophyte, Candida spp., and molds. The risk factors of superficial fungal foot infections are believed from inadequate personal hygiene, frequent use of closed footwear, and high levels of physical activity. Purpose of this study is to investigate the correlation between risk factors and superficial fungal foot infections. An examination of the relationship between the Athletes Foot Severity Score (AFSS) and Dermatology Life Quality Index (DLQI) in military students was conducted to assess the impact on life quality index in individuals exhibiting elevated AFSS scores.
Methods: This is a cross-sectional analytic design with 194 military students as the population. The sample was conducted through consecutive sampling. The inclusion criteria were military students in PUSLATDIKSARMIL exhibiting lesions on feet. Questionnaires were used to ascertain the risk factors associated with superficial fungal foot infections.
Results: This study involved 194 military students, mostly aged 17-25, in which 16.5% exhibited poor personal hygiene, while 74.2% reported wearing closed shoes for over 8 hours. The students demonstrated a high level of physical activity, with an IPAQ score of 26,880 Metabolic Equivalent of Tasks (MET) minutes/week. Notably, 22.7% had severe AFSS scores. Laboratory indicated 30.9% with positive KOH 20% and positive cultures, 27.8% with negative KOH 20% and positive cultures, and 9.3% with positive KOH 20% and negative cultures. Mold was the dominant fungal type affecting 68.4%. There is a correlation between closed contact shoes usage and superficial fungal foot infections. Significant correlation existed between AFSS scores and DLQI.
Conclusion: A strong correlation of the incidence of superficial fungal foot infections and the use of closed shoes were showed. A significant correlation was identified between the AFSS score and the DLQI.
Epigenetic Regulation In Melanogenesis Of Vitiligo
Authors: Sutrini Nyoman Ayu , Praharsini I Gusti Ayu Agung , Herawati Sianny , Lestari AA Wiradewi 
Published: January 2025

Vitiligo is a skin disorder in well-defined depigmented macules due to the loss of melanin. Vitiligo is a complex ailment with multiple causative factors. Research into pathophysiology is ongoing, and there are several challenges. Environmental and oxidative stress are the most significant factors that lead to vitiligo. Eventually, this factor can also affect the epigenetic aspect. Epigenetics is defined as the changes of inherited phenotypic but does not change the DNA sequence. It consists of the DNA methylation process, histone modification, and deactivation of the non-coding RNA (ncRNA) process. A significant difference was found between the melanocyte cell line from vitiligo patients and the normal melanocyte cell line in research that compared the melanocytes of normal persons and those with vitiligo to assess DNA methylation. In vitiligo melanocytes, CpG established a bimodal methylation pattern, with the majority exhibiting hyper- or hypomethylation at 20 distinct loci. It looked at how vitiligo and normal individuals expressed distinct ncRNAs. A higher level of MITF expression, which is unrelated to melanogenesis, is correlated with higher expression of miR-21-5p (p<0.01). Conversely, the Sox5 level was seen as being low. One function of Sox5 is to inhibit MITF. Additionally, the vitiligo group's lncRNA Taurine-upregulated 1 (TUG1) expression was lower (0.4±0.19) than that of the control group (1.028 ±0.08). It indicates the inhibition of melanogenesis by inhibiting the phosphorylation of the ERK/MAPK signaling pathway. In addition, histone modification also plays a crucial role in vitiligo. It is related to melanogenesis and mainly examines histone acetylation.