bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of neonatal hypothermia among very low birth weight infants: a Meta-analysis
Authors: Mohamed Sagad Omer Obeid , Ahmed Sara Mohamed Ibrahim , Khidir Reem Jamal Yousif , Shaheen Mutaz Tarig Hassan Ahmed , Adam Mosab Hussen Mostafa , Ibrahim Basil Abubakr Yagoub , Elmahdi Esra Osama Abdelrahman , Farah Abubaker Shadoul Mohamed 
Published: September 2021

Abstract
Background
Neonatal admission hypothermia (HT) is a frequently encountered problem in neonatal intensive care units (NICUs) and it has been linked to a higher risk of mortality and morbidity. However, there is a disparity in data in the existing literature regarding the prevalence and outcomes associated with HT in very low birth weight (VLBW) infants. This review aimed to provide further summary and analyses of the association between HT and adverse clinical outcomes in VLBW infants.

Methods
In July 2020, we conducted this review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic database search was conducted in MEDLINE (PubMed), Google Scholar, ScienceDirect, World Health Organization Virtual Health Library, Cochrane Library databases, and System for Information on Grey Literature in Europe (SIGLE). We included studies that assessed the prevalence of HT and/or the association between HT and any adverse outcomes in VLBW infants. We calculated the pooled prevalence and Odds Ratio (OR) estimates with the corresponding 95% Confidence Interval (CI) using the Comprehensive meta-analysis software version 3.3 (Biostat, Engle-wood, NJ, USA; http://www.Meta-Analysis.com).

Results
Eighteen studies that fulfilled the eligibility criteria were meta-analyzed. The pooled prevalence of HT among VLBW infants was 48.3% (95% CI, 42.0–54.7%). HT in VLBW infants was significantly associated with mortality (OR = 1.89; 1.72–2.09), intra-ventricular hemorrhage (OR = 1.86; 1.09–3.14), bronchopulmonary dysplasia (OR = 1.28; 1.16–1.40), neonatal sepsis (OR = 1.47; 1.09–2.49), and retinopathy of prematurity (OR = 1.45; 1.28–1.72).

Conclusion
Neonatal HT rate is high in VLBW infants and it is a risk factor for mortality and morbidity in VLBW infants. This review provides a comprehensive view of the prevalence and outcomes of HT in VLBW infants.
Clinical debriefing during the COVID-19 pandemic: hurdles and opportunities for healthcare teams
Authors: Stafford Jody L. , Leon-Castelao Esther , Klein Ikkink Albert J. , Qvindesland Sigrun A. , Garcia-Font Munt , Szyld Demian , Diaz-Navarro Cristina 
Published: September 2021

AbstractThe COVID-19 pandemic and the subsequent pressures on healthcare staff and resources have exacerbated the need for clinical teams to reflect and learn from workplace experiences. Surges in critically ill patients, the impact of the disease on the workforce and long term adjustments in work and life have upturned our normality. Whilst this situation has generated a new ‘connectedness’ within healthcare workers, it also continues to test our resilience.An international multi-professional collaboration has guided the identification of ongoing difficulties to effective communication and debriefing, as well as emerging opportunities to promote a culture of dialogue. This article outlines pandemic related barriers and new possibilities categorising them according to task management, teamwork, situational awareness and decision making. It describes their direct and indirect impact on clinical debriefing and signposts towards solutions to overcome challenges and, building on new bridges, advance team conversations that allow us to learn, improve and support each other.This pandemic has brought clinical professionals together; nevertheless, it is essential to invest in further developing and supporting cohesive teams. Debriefing enables healthcare teams and educators to mitigate stress, build resilience and promote a culture of continuous learning and patient care improvement.
Deficiency in civil registration and vital statistics reporting in remote areas: the case of Sabah, Malaysia
Authors: Lai Siow Li , Tey Nai Peng 
Published: September 2021

AbstractMalaysia has a well-established civil registration system dating back to the 1960s. Birth registration is virtually complete at the national level. However, the quality of civil registration in some remote areas is doubtful, as evidenced by the abnormally low birth and death rates in several districts. This study focuses on identifying districts in Sabah, where the reporting of births seems problematic. Sabah is the least developed state in Malaysia, and it is sparsely populated, despite being the second most populous state in the country. Sabah’s civil registration lags behind the other states, to the extent that birth and death statistics were not reported for the state in the vital statistics report for the period 2000 to 2009. A 2016 study found that death registration is almost 100%, except for Sabah (88%). The plausible reasons behind the ultra-low birth rate reported in several remote districts in Sabah include misreporting of the place of occurrence as the usual residence, delayed reporting, non-coverage, ignorance of the law, inaccessibility, presence of a large number of migrants, miscommunication, and errors in data entry. The under-reporting of births may have serious consequences, such as misallocation of resources and deprivation of services to those affected. In line with the transformative promise of “leaving no one behind,” the Sustainable Development Goals urge all countries to strive to improve data quality for planning; this includes complete birth registration for creating effective development programs to reach target groups more effectively.
Evaluation of the effects of 5-fluorouracil and cyclophosphamide on Lathyrus sativus L.
Authors: Sarkar Priyadharshini , Samanta Aveek , Maity Tilak Raj , Datta Siraj 
Published: September 2021

AbstractBackgroundThe effect of 5-fluorouracil (5FU) and cyclophosphamide (CP) on grass pea (Lathyrus sativusL.) has been studied.ResultsThe effect of the selected drugs on radicle length, colchicine induces polyploidy and in vitro callus growth has been studied (concentration used: 5-Fluorouracil—0.01, 0.1, 1 and 10 mM; Cyclophosphamide—1, 10, 20 and 30 mM). The biochemical studies on superoxide dismutase, catalase and lipid peroxidase activity also studied. Radicle length, polyploidy percentage and callus growth decrease in both the drugs in a dose-dependent manner. The SOD, catalase and LP activity decrease with the increase in drug concentration except for low dose (for 5FU—0.01 mM and 1 mM for CP). Induced polyploidy (Control B) than water germinated seedling (Control A) shows higher enzyme activity but a decrease in the increased dose of drugs.ConclusionsThe present work has been done to assess the effective potentiality of two anticancerous drugs 5FU and CP with an objective to establish plant system as a model for preliminary screening of anticancerous lead compounds. The result of the present work would pave the way for the screening of unknown lead compounds with the potentiality to act as base analogue and DNA cross-linking drugs. This system is faster, cost-effective and convenient than animal model.
Strong synergistic effect of cationic hydrocarbon surfactant and novel nonionic tri-block short-chain fluorocarbon surfactant mixtures on surface activity, wettability and solubilization
Authors: Zhou Yutang , Jin Yong , Shen Yichao , Shi Liangjie , Lai Shuangquan , Tang Yujia 
Published: September 2021

Abstract
Mixing hydrocarbon surfactants with fluorocarbon surfactants is still an important strategy to improve the economic benefits and performances of fluorocarbon surfactants and expand their range of application. Herein, we prepared a novel kind of hydrocarbon-fluorocarbon surfactant mixtures via mixing a cationic surfactant, cetyltrimethylammonium bromide (CTAB), with a tri-block nonionic short-chain fluorocarbon surfactant (F9EG13F9) in aqueous solution. The results showed that adding a small CTAB amount to F9EG13F9 (the molar fraction of CTAB in the mixture (x1) was 0.2) could greatly reduce its critical micelle concentrations (cmc) from 0.408 mmol/L to 0.191 mmol/L. At this x1, the contact angle of the mixture was the minimum (57.7 °) at 100 s on polytetrafluoroethylene film, which was even lower than that of F9EG13F9. Besides, CTAB/F9EG13F9 mixtures possessed better colloidal stability and solubilization ability toward hydrophobic dye (Sudan І) than F9EG13F9. The outstanding performances of binary surfactant mixtures benefited from the non-ideal mixing and strong synergistic effect evidence that CTAB/F9EG13F9 surfactant mixtures could be used in practical applications instead of individual F9EG13F9, thereby reducing the used cost of F9EG13F9.

Graphical abstract
Could native T1 mapping replace late gadolinium enhancement in the assessment of myocardial fibrosis in patients with cardiomyopathy?
Authors: Elsafty Hend G , El Shafey Mohammed , El Arabawy Reda , Mahrous Mary Rabea , Dawoud Tamer Mahmoud 
Published: September 2021

Abstract
Background
Cardiomyopathy is a myocardial disease, which usually demonstrates improper ventricular morphology, function, or both. It is classified into two classes based on the organ involved. Primary cardiomyopathy is confined mainly to the myocardium and can be genetic, non-genetic, or acquired. Secondary cardiomyopathy is caused by generalized systemic disorder. Myocardial fibrosis produces abnormal myocardial stiffness and increases arrhythmias risk. Native T1-mapping is an innovative technique that provides quantitative assessment of edema, diffuse myocardial fibrosis, and inflammation in a number of disease states. Furthermore native T1 mapping provides a future method for quantifying myocardial fibrosis in advanced chronic kidney disease and dialysis patients without the use of gadolinium-based contrast agents. So our aim is to assess the potential value of segmental quantification of myocardial fibrosis using native T1 mapping in different types of cardiomyopathy in comparison to late gadolinium enhancement (LGE) imaging.

Results
The native T1 values of a total 1152 segments (16 segments in 72 patients of cardiomyopathy), 192 segments in 12 patients with hypertrophic cardiomyopathy (HCM), 800 segments in 50 patients with dilated cardiomyopathy (DCM), 80 segments in 5 patients with infiltrative cardiomyopathy, and 80 segments in 5 patients with non-compaction were assessed. These were compared with 160 segments of 10 healthy volunteers. Native T1 values were significantly higher in most of myocardial segments with LGE than in those without including the control group; non-contrast T1 values in mid LV septal segments were found the most significant (1130.85 ± 79.79 ms vs 1047.74 ± 42.74 ms; P = 0.001). Also the current study showed T1 values were significantly higher than normal even in segments unaffected by LGE (P<0.01) in both HCM and DCM groups. A receiver operating characteristic (ROC) analysis revealed the required cutoff value of 1070 ms for detecting myocardial fibrosis with a sensitivity 66% and specificity of 68%.

Conclusion
Contrast-free T1-mapping is a new technique for detecting myocardial fibrosis objectively with a high diagnostic performance especially in patients who cannot afford gadolinium contrast agents as patients with end-stage renal disease.
Comparing inductive and deductive analysis techniques to understand health service implementation problems: a case study of childhood vaccination barriers
Authors: Bonner Carissa , Tuckerman Jane , Kaufman Jessica , Costa Daniel , Durrheim David N. , Trevena Lyndal , Thomas Susan , Danchin Margie 
Published: September 2021

Abstract
Background
Effective implementation requires a comprehensive understanding of individual, organisational and system determinants. This study aimed to compare inductive and deductive analysis techniques to understand a complex implementation issue. We used childhood vaccination as a case study, an issue with wide-ranging barriers contributing to low-vaccine uptake internationally.

Methods
The study is based on the Behaviour Change Wheel framework, which was derived from several levels of theory: the 3 components of the COM-B framework (capability, opportunity and motivation) can be mapped to the 14 domains of the Theoretical Domains Framework (TDF), which is based on 84 underlying constructs. We first conducted a review of systematic reviews of parent-level barriers to childhood vaccination. Subsequently we (1) inductively coded these barriers into a data-driven framework, using thematic analysis, and (2) deductively mapped the barriers to COM-B and TDF domains and constructs. These processes were undertaken by two authors independently, and discrepancies were resolved through discussion. Inductive and deductive results were compared.

Results
The inductive process coded 583 descriptions of barriers identified from the literature into a framework of 74 barriers in 7 categories. The initial definitions used to map the barriers to deductive domains/constructs led to 89% agreement at the domain level. Resolving discrepancies required further definitions at the construct level. Of the 14 TDF domains, 10 were clearly identified in the data from the barrier reviews. Some domains were not specific enough to differentiate between types of barriers (e.g. Environmental Context and Resources), while other domains were not represented in the review data (e.g. Behavioural Regulation).

Conclusions
Using both inductive and deductive analysis techniques can help achieve a more comprehensive understanding of barriers to health service implementation. The inductive categories represented the review data in a clearer way than the theoretical domains, with better differentiation; but the missing deductive domains were useful as a way to identify additional issues to investigate further. Both analysis techniques resulted in a comprehensive list of barriers to vaccination that would not have been achieved using either approach alone. We recommend a hybrid approach combining TDF with broader frameworks, for future researchers conducting evidence syntheses.
The Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines
Authors: Tan HuiLing , Ding ZhenDong , Zhang ChengLiang , Yan JianQin , Yang Yong , Li Ping 
Published: September 2021

BACKGROUND:
The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. We examined the relationship between the antinociceptive effect and the expression level of programmed cell death ligand-1 (PD-L1) during pregnancy and further observed the changes in pain thresholds and expression levels of cytokines in late-pregnant mice before and after blockade of PD-L1 or programmed cell death-1 (PD-1).

METHODS:
Part 1: Female mice were assigned to 3 groups (nonpregnant, late-pregnant, and postpartum). Part 2: Late-pregnant mice were assigned to 3 treatment groups (control [phosphate buffer solution], RMP1-14 [mouse anti–PD-1 antibody], and soluble PD-1 [sPD-1]). Behavioral testing (mechanical and thermal) and tissue (serum and spinal cord) analysis were performed on all groups. PD-L1, interleukin (IL)-10, tumor necrosis factor-α (TNF-α), and IL-6 expression levels in tissue were examined via reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and Western blot analysis.

RESULTS:
The mechanical and thermal pain thresholds were significantly increased in late pregnancy and decreased after delivery. PD-L1 expression was also elevated in late pregnancy and decreased after delivery. In addition, in the late stage of gestation, the maternal inflammatory microenvironment was dominated by anti-inflammatory factors. After administration of RMP1-14 or sPD-1, the pain thresholds of late-pregnant mice were significantly reduced. In late-pregnant mice, the high level of IL-10 was obviously reduced, and the low levels of TNF-α and IL-6 were elevated.

CONCLUSIONS:
The PD-L1/PD-1 pathway mediates pregnancy-induced analgesia, partially via the regulation of cytokines.
The Political Realignment of Health: How Partisan Power Shaped Infant Health in the United States, 1915–2017
Authors: Rodríguez Javier M. , Bae Byengseon , Geronimus Arline T. , Bound John 
Published: September 2021

Abstract
The US two-party system was transformed in the 1960s when the Democratic Party abandoned its Jim Crow protectionism to incorporate the policy agenda fostered by the civil rights movement, and the Republican Party redirected its platform toward socioeconomic and racial conservatism. The authors argue that the policy agendas promoted by the two parties through presidents and state legislatures codify a racially patterned access to resources and power detrimental to the health of all. To test the hypothesis that fluctuations in overall and race-specific infant mortality rates (IMRs) shift between the parties in power before and after the political realignment (PR), the authors apply panel data analysis methods to state-level data from the National Center for Health Statistics for the period 1915 through 2017. Net of trend, overall, and race-specific IMRs were not statistically different between presidential parties before the PR. This pattern, however, changed after the PR, with Republican administrations consistently underperforming Democratic ones. Net of trend, non-Southern state legislatures controlled by Republicans underperform Democratic ones in overall and racial IMRs in both periods.
Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the endoplasmic reticulum
Authors: Mallo Natalia , Ovciarikova Jana , Martins-Duarte Erica S. , Baehr Stephan C. , Biddau Marco , Wilde Mary-Louise , Uboldi Alessandro D. , Lemgruber Leandro , Tonkin Christopher J. , Wideman Jeremy G. , Harding Clare R. , Sheiner Lilach 
Published: September 2021

ABSTRACT
The voltage-dependent anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles in protein, metabolite and small molecule transport. In mammalian cells, VDAC protein, as part of a larger complex including the inositol triphosphate receptor, has been shown to have a role in mediating contacts between the mitochondria and endoplasmic reticulum (ER). We identify VDAC of the pathogenic apicomplexan Toxoplasma gondii and demonstrate its importance for parasite growth. We show that VDAC is involved in protein import and metabolite transfer to mitochondria. Further, depletion of VDAC resulted in significant morphological changes in the mitochondrion and ER, suggesting a role in mediating contacts between these organelles in T. gondii.
This article has an associated First Person interview with the first author of the paper.
Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast
Authors: Rich-Robinson Julie , Russell Afton , Mancini Eleanor , Das Maitreyi 
Published: September 2021

ABSTRACT
In fission yeast, polarized cell growth stops during division and resumes after cytokinesis completes and cells separate. It is unclear how growth reactivation is timed to occur immediately after cell separation. We uncoupled these sequential events by delaying cytokinesis with a temporary Latrunculin A treatment. Mitotic cells recovering from treatment initiate end growth during septation, displaying a polar elongation simultaneous with septation (PrESS) phenotype. PrESS cell ends reactivate Cdc42, a major regulator of polarized growth, during septation, but at a fixed time after anaphase B. A candidate screen implicates Rga4, a negative regulator of Cdc42, in this process. We show that Rga4 appears punctate at the cell sides during G2, but is diffuse during mitosis, extending to the ends. Although the Morphogenesis Orb6 (MOR) pathway is known to promote cell separation and growth by activating protein synthesis, we find that, for polarized growth, removal of Rga4 from the ends is also necessary. Therefore, we propose that growth resumes after division once the MOR pathway is activated and the ends lose Rga4 in a cell-cycle-dependent manner.
RESPONSABILIDADE SOCIAL UNIVERSITÁRIA LEVINASIANA E A FORMAÇÃO DA CONSCIÊNCIA SOCIAL SOB O OLHAR DE DISCENTES DE SECRETARIADO EXECUTIVO
Authors: Barros Conceição de Maria Pinheiro , Gonçalves Sara Costa 
Published: September 2021

Este trabalho tem por objetivo analisar as contribuições da participação em ações de Responsabilidade Social Universitária, na perspectiva levinasiana, para a formação da consciência social, na percepção de discentes de Secretariado Executivo. Para tanto, foi realizada uma pesquisa qualitativa e descritiva, por meio de um levantamento teórico e um estudo de campo com a participação de quatro representantes discentes do curso de Secretariado Executivo da Universidade Federal do Ceará. Como técnica de pesquisa, definiu-se a entrevista reflexiva e utilizou-se um roteiro, como instrumento de coleta de dados. Para a análise das informações, recorreu-se à técnica de análise reflexiva. Concluiu-se que participar de ações de Responsabilidade Social Universitária proporciona contato com o diferente e, dessa forma, o sujeito amplia sua visão sobre a sociedade, gera alteridade e respeito às diferenças e senso de responsabilidade para com o Outro, culminando no desenvolvimento de uma consciência social.
An embedded randomised controlled retention trial of personalised text messages compared to non-personalised text messages in an orthopaedic setting
Authors: Mitchell Alex S. , Cook Liz , Dean Alexandra , Fairhurst Caroline , Northgraves Matthew , Torgerson David J. , Reed Mike 
Published: September 2021

Background: Several studies have investigated whether personalising trial documentation can aid recruitment and retention. We did a ‘study within a trial’ (SWAT) evaluating the effectiveness of a personalised text message compared to a non-personalised text message, on the retention rate in a large orthopaedic trial. Methods: The SWAT was embedded in the Knee Replacement Bandaging Study (KReBS) trial. The primary outcome was the proportion of 12-month questionnaires returned. Secondary outcomes were the proportion of questionnaires completed and time to questionnaire return. Binary data were analysed using logistic regression and time to return using Cox proportional hazards regression. Odds ratios (OR) and hazard ratios (HR) are presented, with associated 95% confidence intervals (CI) and p-values. Results: In total, 1465 participants were included in the SWAT. In the personalised group, 644/723 (89.1%) of participants returned a questionnaire, compared to 654/742 (88.1%) in the non-personalised group. The absolute difference in return rate was 0.9% (95% CI: -2.3% to 4.2%; p=0.57). There was no evidence of a difference between the groups in the likelihood of returning a questionnaire (OR 1.09; 95% CI: 0.79 to 1.51; p=0.61), the likelihood of returning a complete questionnaire (OR 1.11; 95% CI: 0.82 to 1.51; p=0.50) nor in time to return (HR 1.05; 95% CI: 0.94 to 1.17; p=0.40). Conclusion: This SWAT adds to the growing evidence base for whether personalised text messages are effective. Registration: ISRCTN87127065 (20/02/2017); SWAT 35 (01/12/2015)