bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptotic Stability of the Sphere’s Rolling Equilibrium
Authors: Das Tuhin 
Published: April 2021

Abstract
The classical phenomenon of a sphere transitioning from sliding to rolling during its motion on a horizontal plane is investigated from a novel system theoretic perspective. Specifically, the transition is studied as a problem in stabilization, an approach not reported in the literature. The main contribution of this paper is in proving that pure rolling is an asymptotically stable equilibrium within the state-space of a sliding sphere. It is shown that the stabilization of this equilibrium from arbitrary initial conditions occurs through the natural interplay between the friction force and moment that result from sliding. Simulation results confirm the theoretical development. The stability analysis is extended to motion on an inclined plane.
Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
Authors: Monroe-Wise Aliza , Mbogo Loice , Guthrie Brandon , Bukusi David , Sambai Betsy , Chohan Bhavna , Scott John , Cherutich Peter , Musyoki Helgar , Bosire Rose , Dunbar Matthew , Macharia Paul , Masyuko Sarah , Wilkinson Eduan , De Oliveira Tulio , Ludwig-Barron Natasha , Sinkele Bill , Herbeck Joshua , Farquhar Carey 
Published: April 2021

IntroductionTargeted, tailored interventions to test high-risk individuals for HIV and hepatitis C virus (HCV) are vital to achieving HIV control and HCV microelimination in Africa. Compared with the general population, people who inject drugs (PWID) are at increased risk of HIV and HCV and are less likely to be tested or successfully treated. Assisted partner services (APS) increases HIV testing among partners of people living with HIV and improves case finding and linkage to care. We describe a study in Kenya examining whether APS can be adapted to find, test and link to HIV care the partners of HIV-positive PWID using a network of community-embedded peer educators (PEs). Our study also identifies HCV-positive partners and uses phylogenetic analysis to determine risk factors for onward transmission of both viruses.MethodsThis prospective cohort study leverages a network of PEs to identify 1000 HIV-positive PWID for enrolment as index participants. Each index completes a questionnaire and provides names and contact information of all sexual and injecting partners during the previous 3 years. PEs then use a stepwise locator protocol to engage partners in the community and bring them to study sites for enrolment, questionnaire completion and rapid HIV and HCV testing. Outcomes include number and type of partners per index who are mentioned, enrolled, tested, diagnosed with HIV and HCV and linked to care.Ethics and disseminationPotential index participants are screened for intimate partner violence (IPV) and those at high risk are not eligible to enrol. Those at medium risk are monitored for IPV following enrolment. A community advisory board engages in feedback and discussion between the community and the research team. A safety monitoring board discusses study progress and reviews data, including IPV monitoring data. Dissemination plans include presentations at quarterly Ministry of Health meetings, local and international conferences and publications.Trial registration numberNCT03447210, Pre-results stage.
Implementing the US Department of Health and Human Services definition of multimorbidity: a comparison between billing codes and medical record review in a population-based sample of persons 40–84 years old
Authors: St Sauver Jennifer L , Chamberlain Alanna M , Bobo William V , Boyd Cynthia M , Finney Rutten Lila J , Jacobson Debra J , McGree Michaela E , Grossardt Brandon R , Rocca Walter A 
Published: April 2021

ObjectiveTo assess the validity of the US Department of Health and Human Services (DHHS) definition of multimorbidity using International Classification of Diseases, ninth edition (ICD-9) codes from administrative data.DesignCross-sectional comparison of two ICD-9 billing code algorithms to data abstracted from medical records.SettingOlmsted County, Minnesota, USA.ParticipantsAn age-stratified and sex-stratified random sample of 1509 persons ages 40–84 years old residing in Olmsted County on 31 December 2010.Study measuresSeventeen chronic conditions identified by the US DHHS as important in studies of multimorbidity were identified through medical record review of each participant between 2006 and 2010. ICD-9 administrative billing codes corresponding to the 17 conditions were extracted using the Rochester Epidemiology Project records-linkage system. Persons were classified as having each condition using two algorithms: at least one code or at least two codes separated by more than 30 days. We compared the ICD-9 code algorithms with the diagnoses obtained through medical record review to identify persons with multimorbidity (defined as ≥2, ≥3 or ≥4 chronic conditions).ResultsUse of a single code to define each of the 17 chronic conditions resulted in sensitivity and positive predictive values (PPV) ≥70%, and in specificity and negative predictive values (NPV) ≥70% for identifying multimorbidity in the overall study population. PPV and sensitivity were highest in persons 65–84 years of age, whereas NPV and specificity were highest in persons 40–64 years. The results varied by condition, and by age and sex. The use of at least two codes reduced sensitivity, but increased specificity.ConclusionsThe use of a single code to identify each of the 17 chronic conditions may be a simple and valid method to identify persons who meet the DHHS definition of multimorbidity in populations with similar demographic, socioeconomic, and health care characteristics.
Untangling the inter-relatedness within integrated care programmes for community-dwelling frail older people: a rapid realist review
Authors: Ahmed Anam , van den Muijsenbergh Maria E T C , Mewes Janne C , Wodchis Walter P , Vrijhoef Hubertus J M 
Published: April 2021

ObjectiveTo identify the relationships between the context in which integrated care programmes (ICPs) for community-dwelling frail older people are applied, the mechanisms by which the programmes do (not) work and the outcomes resulting from this interaction by establishing a programme theory.DesignRapid realist review.Inclusion criteriaReviews and meta-analyses (January 2013–January 2019) and non-peer-reviewed literature (January 2013–December 2019) reporting on integrated care for community-dwelling frail older people (≥60 years).AnalysisSelection and appraisal of documents was based on relevance and rigour according to the Realist And Meta-narrative Evidence Syntheses: Evolving Standards criteria. Data on context, mechanisms, programme activities and outcomes were extracted. Factors were categorised into the five strategies of the WHO framework of integrated people-centred health services (IPCHS).Results27 papers were included. The following programme theory was developed: it is essential to establish multidisciplinary teams of competent healthcare providers (HCPs) providing person-centred care, closely working together and communicating effectively with other stakeholders. Older people and informal caregivers should be involved in the care process. Financial support, efficient use of information technology and organisational alignment are also essential. ICPs demonstrate positive effects on the functionality of older people, satisfaction of older people, informal caregivers and HCPs, and a delayed placement in a nursing home. Heterogeneous effects were found for hospital-related outcomes, quality of life, healthcare costs and use of healthcare services. The two most prevalent WHO-IPCHS strategies as part of ICPs are ‘creating an enabling environment’, followed by ‘strengthening governance and accountability’.ConclusionCurrently, most ICPs do not address all WHO-IPCHS strategies. In order to optimise ICPs for frail older people the interaction between context items, mechanisms, programme activities and the outcomes should be taken into account from different perspectives (system, organisation, service delivery, HCP and patient).
Gender inequality and the double burden of disease in low-income and middle-income countries: an ecological study
Authors: van der Ham Mirte , Bolijn Renee , de Vries Alcira , Campos Ponce Maiza , van Valkengoed Irene G M 
Published: April 2021

IntroductionMany low-income and middle-income countries (LMIC) suffer from a double burden of infectious diseases (ID) and non-communicable diseases (NCD). Previous research suggests that a high rate of gender inequality is associated with a higher ID and NCD burden in LMIC, but it is unknown whether gender inequality is also associated with a double burden of disease. In this ecological study, we explored the association between gender inequality and the double burden of disease in LMIC.MethodsFor 108 LMIC, we retrieved the Gender Inequality Index (GII, scale 0–1) and calculated the double burden of disease, based on disability-adjusted life-years for a selection of relevant ID and NCD, using WHO data. We performed logistic regression analysis to study the association between gender inequality and the double burden of disease for the total population, and stratified for men and women. We adjusted for income, political stability, type of labour, urbanisation, government health expenditure, health infrastructure and unemployment. Additionally, we conducted linear regression models for the ID and NCD separately.ResultsThe GII ranged from 0.13 to 0.83. A total of 37 LMIC had a double burden of disease. Overall, the adjusted OR for double burden of disease was 1.05 per 0.01 increase of GII (95% CI 0.99 to 1.10, p=0.10). For women, there was a borderline significant positive association between gender inequality and double burden of disease (OR 1.05, 95% CI 1.00 to 1.11, p=0.06), while there was no association in men (OR 0.99, 95% CI 0.95 to 1.04, p=0.75).ConclusionWe found patterns directing towards a positive association between gender inequality and double burden of disease, overall and in women. This finding suggests the need for more attention for structural factors underlying gender inequality to potentially reduce the double burden of disease.
Reducing time to differentiated service delivery for newly diagnosed people living with HIV in Kigali, Rwanda: study protocol for a pilot, unblinded, randomised controlled study
Authors: Ross Jonathan , Murenzi Gad , Hill Sarah , Remera Eric , Ingabire Charles , Umwiza Francine , Munyaneza Athanase , Muhoza Benjamin , Habimana Dominique Savio , Mugwaneza Placidie , Zhang Chenshu , Yotebieng Marcel , Anastos Kathryn 
Published: April 2021

IntroductionCurrent HIV guidelines recommend differentiated service delivery (DSD) models that allow for fewer health centre visits for clinically stable people living with HIV (PLHIV). Newly diagnosed PLHIV may require more intensive care early in their treatment course, yet frequent appointments can be burdensome to patients and health systems. Determining the optimal parameters for defining clinical stability and transitioning to less frequent appointments could decrease patient burden and health system costs. The objectives of this pilot study are to explore the feasibility and acceptability of (1) reducing the time to DSD from 12 to 6 months after antiretroviral therapy (ART) initiation,and (2) reducing the number of suppressed viral loads required to enter DSD from two to one.Methods and analysesThe present study is a pilot, unblinded trial taking place in three health facilities in Kigali, Rwanda. Current Rwandan guidelines require PLHIV to be on ART for ≥12 months with two consecutive suppressed viral loads in order to transition to less frequent appointments. We will randomise 90 participants to one of three arms: entry into DSD at 6 months after one suppressed viral load (n=30), entry into DSD at 6 months after two suppressed viral loads (n=30) or current standard of care (n=30). We will measure feasibility and acceptability of this intervention; clinical outcomes include viral suppression at 12 months (primary outcome) and appointment attendance (secondary outcome).Ethics and disseminationThis clinical trial was approved by the institutional review board of Albert Einstein College of Medicine and by the Rwanda National Ethics Committee. Findings will be disseminated through conferences and peer-reviewed publications, as well as meetings with stakeholders.Trial registration numberNCT04567693.
Acceptability of intravitreal injections in geographic atrophy: protocol for a mixed-methods pilot study
Authors: Enoch Jamie , Ghulakhszian Arevik , Crabb David P , Dinah Christiana , Taylor Deanna J 
Published: April 2021

IntroductionAge-related macular degeneration (AMD) is a common cause of visual impairment, affecting central vision. Geographic atrophy (GA) is an advanced form of the non-neovascular (dry) type of AMD. Late-stage clinical trials suggest that intravitreal injections of novel therapeutics may slow down the rate of GA progression by up to 30% in 1 year, thus allowing people with GA to preserve central vision for a longer period. While intravitreal injections have become an established treatment modality for neovascular (wet) AMD, it is unknown whether patients with (more gradually progressing) GA would accept regular injections that slow down, but do not stop or reverse, vision loss. Therefore, this mixed-methods pilot study will aim to explore whether regular intravitreal injections will be acceptable as treatment for patients with GA, and the factors that may affect treatment acceptability.Methods and analysisA mixed-methods survey has been designed in collaboration with a GA patient advisory group. The survey comprises of structured questionnaires, semi-structured interview questions regarding patients’ perceptions of intravitreal injections and the burden of treatment, and a task eliciting preferences between different potential treatments. Due to COVID-19 restrictions, this study will be conducted remotely by telephone. Thirty individuals will be recruited from NHS Medical Retina clinics at Central Middlesex Hospital, London. Half of the participants will be naïve to intravitreal injections, while half will have previous experience of intravitreal injections for neovascular (wet) AMD. Qualitative data analysis will be conducted using the Framework Method of analysis to identify key themes from participants’ accounts.Ethics and disseminationThe study received Health Research Authority approval on 23 March 2021 (IRAS Project ID: 287824). Findings will be disseminated through peer-reviewed publications and conference presentations to the medical retina community, as well as through dialogue with patients and macular disease charities.
Nationwide seroprevalence of antibodies to SARS-CoV-2 in asymptomatic population in South Korea: a cross-sectional study
Authors: Nah Eun-Hee , Cho Seon , Park Hyeran , Hwang Inhwan , Cho Han-Ik 
Published: April 2021

ObjectiveAsymptomatic active infection might be an important contributor to the COVID-19 outbreak. Serological tests can assess the extent of exposure and herd immunity to COVID-19 in general populations. This study aimed to estimate the nationwide seroprevalence of SARS-CoV-2 antibodies according to age, sex and clinical status in South Korea.Design, setting and participantsThis cross-sectional study randomly selected health examinees who underwent health check-up at 16 health promotion centres in 13 Korean cities across the country between late September and early December 2020. Residual serum samples were obtained from 4085 subjects (2014 men and 2071 women). Antibodies to SARS-CoV-2 were measured by electrochemiluminescence immunoassay using Elecsys Anti-SARS-CoV-2 (Roche Elecsys, Mannheim, Germany).Primary and secondary outcome measuresFisher’s exact test was used to compare the seroprevalence according to sex, age group and region. The relative risks of being seropositive according to the characteristics of the study subjects were analysed using logistic regression analysis.ResultsThe overall seroprevalence of anti-SARS-CoV-2 was 0.39% (95% CI=0.20% to 0.58%): 0.30% (95% CI=0.06% to 0.54%) for men and 0.48% (95% CI=0.18% to 0.78%) for women. The rate of anti-SARS-CoV-2 positivity varied significantly between different regions of Korea (p=0.003), but not with age group, sex, or the statuses of obesity, diabetes, hypertension or smoking.ConclusionsMost of the Korean population is still immunologically vulnerable to SARS-CoV-2, but the seroprevalence has increased relative to that found in studies performed prior to September 2020 in Korea.
Determinants of COVID-19-related knowledge and preventive behaviours among students in reopened secondary schools: cross-sectional study
Authors: Handebo Simegnew , Adugna Asmamaw , Kassie Ayenew , Shitu Kegnie 
Published: April 2021

PurposeIn Ethiopia, more than 26 million students have been out of the classroom for nearly 9 months. On 18 September, the Ethiopian Minister of Health advised the Parliament the possibility of reopening schools provided certain conditions were met. Schools are currently reopening in the country for the first time since March 2020.ObjectiveThis study assessed the knowledge and preventive health behaviours toward COVID-19 and associated factors among secondary school students.Design, setting, participants and outcome measuresAn institution-based cross-sectional study was conducted from October to December 2020 in Gondar city, Northwest Ethiopia. A total of 370 secondary school students were included. Bivariable and multivariable ordinal logistic regression model were fitted to identify the predictors of knowledge about COVID-19. Simple and multiple linear regression analysis were done to identify factors associated with preventive behaviour. A p<0.05 was used to declare statistical significance.ResultsOnly one-fourth (23.5%, 95% CI 19.5% to 28.1%) of the participants had a good knowledge about COVID-19. The mean score of preventive behaviour was 22.8±SD 6.2. Marital status, religion, father education, living arrangement and sources of information were significantly associated with knowledge about COVID-19. Being female and using health professionals as source of information increased the engagement in preventive behaviours. On the other hand, student whose father employed in non-governmental organisation and other jobs had decreased engagement in preventive health behaviours.ConclusionSignificant number of the students had inadequate knowledge about COVID-19 and poorly engaged in COVID-19 preventive behaviour. Thus, it is suggested to include and disseminate about COVID-19 in related academic sessions, using school clubs and minimedias. The sources of COVID-19-related information need to strengthen the dissemination of tailored, credible and timely message to enhance the knowledge and engagement of the students in preventive behaviours.
International Crimes or Ordinary Crimes? The ‘Dual Classification of the Facts’ as an Interpretive Method
Authors: Maculan Elena 
Published: April 2021

Abstract
Many domestic courts, when prosecuting atrocities committed in their dictatorial or warring past, have been facing a real dilemma: whether to classify the facts as ordinary crimes, foreseen by the domestic legislation prior to the facts and therefore consistent with the principles of legality and non-retroactivity, or as international crimes, which do not grant the same compatibility but allow to overcome the obstacles to prosecution imposed by statutory limitations and amnesties. The paper focuses on an interpretative method developed by several Latin American tribunals to overcome this impasse, by means of a combined application of the two criminal categories. Although this ‘dual classification of facts’ apparently solves the dilemma, it is flawed from both a methodological and substantive perspective. After scrutinising these problematic issues, the paper analyses some alternative interpretative proposals that may also allow to avoid impunity, but without impinging on fundamental principles of modern criminal law systems.
Transitional Justice, Institutions and Temporality: Towards a Dynamic Understanding
Authors: McAuliffe Pádraig 
Published: April 2021

Abstract
This article examines the impact of institutionalisation of governance, bureaucracy and rule of law on the timeframes employed for transitional justice. It argues that the urgency of transitional justice has consistently given way to temporally extended justice projects as state strength permits revision of initial leniency in terms of truth, criminal accountability and vetting, while state weaknesses compel the delay of projects pending institutional development or consolidation through long-term peacebuilding missions. Furthermore, a more recent focus on transformative social change that looks at economic root causes of conflict would require states and policy-makers to use a longer, multigenerational timeframe for action. In the absence of theoretical work on how these multi-generational commitments might be realised, this article draws on literature in the field of development to outline a plausible model for how transitional justice, peacebuilding and development are dynamically realised over time. It argues that for transitional justice to be even minimally transformative, it must be embedded in top-down developmental institutions of government sufficiently robust to implement recommendations. It must also be embedded in bottom-up developmental coalitions whose everyday political contests can shape the structure and effects of these institutions over time.
Be the First Investor to Eat Crabs in North Korea: Tips for Bilateral Investment Treaties
Authors: Ma Xuechan , Zhang Anran 
Published: April 2021

Abstract
As the last economic frontier in Northeast Asia, North Korea is a promising land but at the same time a risky land for foreign investment. The ‘dual-track’ policy of advancing both the political stability and economic development promoted by the present leader of North Korea, Kim Jong-un, has prompted the outside world to speculate that he is determined to gradually open the doors to the economy of North Korea to attract foreign investment as initial capital to mobilise domestic economic growth. By conducting a systemic and comparative analysis of the existing bilateral investment treaties (BIT s) signed by North Korea in the Kim Jong-il era, this article has put forward eight tips that can better prepare those daredevils who are interested in seizing the future opportunity to invest in North Korea in the present Kim Jong-un era. It is predicted that denuclearisation will bring a new era for North Korean BIT s.
Quantum (In)Justice: Rethinking the Calculation of Compensation and Damages in ISDS
Authors: Marzal Toni 
Published: April 2021

Abstract
The present article seeks to critically rethink the key issue of how compensation and damages are and should be calculated in the context of investor-State arbitration – the ‘quantum’ question, as is commonly referred to in arbitral practice. We will make three main claims: first that such calculations are premised on a fundamental consensus that presents the work of arbitrators in this area as essentially uncontroversial fact-finding operations and has led to an inflation of awards, second that this consensus is in reality built on a series of myths and unjustifiable assumptions, and third that the realization that this is so should lay the ground for more acceptable calculations.