bluuebunny/crossref_metadata_2025_split huggingface dataset:
The road taken and the path forward for HR devolution research: An evolutionary review
Authors: Kurdi‐Nakra Hussein , Kou Xuan , Pak Jongwook 
Published: October 2021

AbstractDevolving HR responsibilities to the line is a distinguishable feature in modern human resource management (HRM). Given its considerable influence on the modus operandi of adopted HRM systems, scholars have delved into barriers to and facilitating conditions of line managers' fulfilling their HR duties and its subsequent outcomes over the past several decades. To deepen our understanding of the current state of the HR devolution literature, we adopt an evolutionary approach that moves beyond a conventional theme‐centric review. Exploring the extant literature from a chronological stance offers a unique perspective since such an approach allows us to track and evaluate the development trajectory from its inception. Indeed, our evolutionary review reveals that critical observations on HR devolution practices documented by early studies (e.g., conflicts between line managers and HR professionals) have not been as articulated as they should be in recent endeavors (e.g., focus on line managers' competency and motivation). Through this review, we shed new light on the HR devolution literature and call for revisiting important yet unresolved issues that still resonate today. In addition, we contemplate the future of HR devolution practices amid a changing business landscape and suggest promising research avenues accordingly. By looking back at the road taken and paving the path forward, the current review will offer a guidepost benefiting both aspiring researchers and seasoned scholars in the field.
Numerical solution of the Jeffery–Hamel flow through the wavelet technique
Authors: Kumbinarasaiah S. , Raghunatha K. R. 
Published: October 2021

AbstractThe theory of viscous fluid flow through convergent and divergent channels has many applications in chemical, aerospace, civil, biomechanical, mechanical, and environmental engineering. It also plays a role in sympathetic rivers and canals and in human anatomy, in how capillaries and arteries are linked. In this study, we developed a new operational matrix of integration with the Hermite wavelet. We proposed a new method called the Hermite wavelet method (HWM) to solve the highly nonlinear Jeffery–Hamel flow problem. The proposed technique is beneficial and appropriate for solving nonlinear differential equations. Furthermore, the outcomes are compared with other techniques such as differential transformation method, homotopy perturbation method, variational iteration method, and Runge–Kutta method in the literature, revealing that the current method's solution is better than those of other methods. The obtained results show that HWM is more satisfactory and precise than the other known techniques in the literature. Also, the property of Reynolds number, convergent, and divergent replica of the channel on applications of the Jeffery–Hamel flow is discussed.
Target‐based drug repurposing against Candida albicans—A computational modeling, docking, and molecular dynamic simulations study
Authors: Verma Rashi , Pradhan Dibyabhaba , Nayek Arnab , Singh Harpreet , Jain Arun Kumar , Khan Luqman Ahmad 
Published: October 2021

AbstractThe emergence of multidrug‐resistant strains of Candida albicans has become a global threat mostly due to co‐infection with immune‐compromised patients leading to invasive candidiasis. The life‐threatening form of the disease can be managed quickly and effectively by drug repurposing. Thus, the study used in silico approaches to evaluate Food and Drug Administration (FDA) approved drugs against three drug targets—TRR1, TOM40, and YHB1. The tertiary structures of three drug targets were modeled, refined, and evaluated for their structural integrity based on PROCHECK, ERRAT, and PROSA. High‐throughput virtual screening of FDA‐approved drugs (8815), interaction analysis, and energy profiles had revealed that DB01102 (Arbutamine), DB01611 (Hydroxychloroquine), and DB09319 (Carindacillin) exhibited better binding affinity with TRR1, TOM40, and YHB1, respectively. Notably, the molecular dynamic simulation explored that Gln45, Thr119, and Asp288 of TRR1; Thr107 and Ser121 of TOM40; Arg193, Glu213, and Ser228 of YHB1 are crucial residues for stable drug‐target interaction. Additionally, it also prioritized Arbutamine‐TRR1 as the best drug‐target complex based on MM‐PBSA (−52.72 kcal/mol), RMSD (2.43 Å), and radius of gyration (−21.49 Å) analysis. In‐depth, PCA results supported the findings of molecular dynamic simulations. Interestingly, the conserved region (>70%) among the TRR1 sequences from pathogenic Candida species indicated the effectiveness of Arbutamine against multiple species of Candida as well. Thus, the study dispenses new insight and enriches the understanding of developing an advanced technique to consider potential antifungals against C. albicans. Nonetheless, a detailed experimental validation is needed to investigate the efficacy of Arbutamin against life‐threatening candidiasis.
Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary
Authors: Bhardwaj Jitender K. , Paliwal Aakansha , Saraf Priyanka , Sachdeva Som N. 
Published: October 2021

AbstractThe reproductive life span of the organism mainly depends on follicular development that maintains the primordial follicle pool in the cohort of follicles within the ovary. The total count of primordial follicles decreases with age due to ovulation and follicular atresia. Follicular atresia, a process of ovarian follicles degradation, mainly occurs via apoptosis, but recent studies also favor autophagy existence. Autophagy is a cellular and energy homeostatic response that helps to maintain the number of healthy primordial follicles, germ cell survival, and removal of corpus luteum remnants. But the excessive autophagic cell death changes both the quality and quantity of oocytes that ultimately affect female reproductive health. Autophagy regulation occurs by various autophagy‐regulated genes like BECN1 and LC3‐II (autophagy marker genes). Their abnormal regulation or mutation highly influences follicular development by alteration of primordial follicles formation, the decline in oocytes count, and germ cell loss. Various classical signaling pathways such as PI3K/AKT/mTOR, MAPK/ERK1/2, AMPK, and IRE1 are involved in granulosa and oocytes autophagy, while mTOR signaling is the primary mechanism. Along with basal level autophagy, chemical/hormone/stress‐mediated autophagy also affects follicular development and female reproduction. In this review, we have primarily focused on granulosa cell and oocytes' autophagy, mechanism, and the role of autophagy determining marker genes in follicular development.
Loss of REDD1 prevents chemotherapy‐induced muscle atrophy and weakness in mice
Authors: Hain Brian A. , Xu Haifang , Waning David L. 
Published: October 2021

AbstractBackgroundChemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting and weakness. Regulated in Development and DNA Damage Response 1 (REDD1) is a stress‐response protein that represses the mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1), and its expression is increased in models of muscle wasting. The aim of this study was to determine if deletion of REDD1 is sufficient to attenuate chemotherapy‐induced muscle wasting and weakness in mice.MethodsC2C12 myotubes were treated with carboplatin, and changes in myotube diameter were measured. Protein synthesis was measured by puromycin incorporation, and REDD1 mRNA and protein expression were analysed in myotubes treated with carboplatin. Markers of mTORC1 signalling were measured by western blot. REDD1 global knockout mice and wild‐type mice were treated with a single dose of carboplatin and euthanized 7 days later. Body weight, hindlimb muscle weights, forelimb grip strength, and extensor digitorum longus whole muscle contractility were measured in all groups. Thirty minutes prior to euthanasia, mice were injected with puromycin to measure puromycin incorporation in skeletal muscle.ResultsC2C12 myotube diameter was decreased at 24 (P = 0.0002) and 48 h (P < 0.0001) after carboplatin treatment. Puromycin incorporation was decreased in myotubes treated with carboplatin for 24 (P = 0.0068) and 48 h (P = 0.0008). REDD1 mRNA and protein expression were increased with carboplatin treatment (P = 0.0267 and P = 0.0015, respectively), and this was accompanied by decreased phosphorylation of Akt T308 (P < 0.0001) and S473 (P = 0.0006), p70S6K T389 (P = 0.0002), and 4E‐binding protein 1 S65 (P = 0.0341), all markers of mTORC1 activity. REDD1 mRNA expression was increased in muscles from mice treated with carboplatin (P = 0.0295). Loss of REDD1 reduced carboplatin‐induced body weight loss (P = 0.0013) and prevented muscle atrophy in mice. REDD1 deletion prevented carboplatin‐induced decrease of protein synthesis (P = 0.7626) and prevented muscle weakness.ConclusionsCarboplatin caused loss of body weight, muscle atrophy, muscle weakness, and inhibition of protein synthesis. Loss of REDD1 attenuates muscle atrophy and weakness in mice treated with carboplatin. Our study illustrates the importance of REDD1 in the regulation of muscle mass with chemotherapy treatment and may be an attractive therapeutic target to combat cachexia.
Assembly of peptide linker to amino acid dehydrogenase and immobilized with metal–organic framework
Authors: Wang Shiyan , Duan Lingxuan , Jiang Liang , Liu Kailong , Wang Shizhen 
Published: October 2021

AbstractBACKGROUNDThe metal–organic framework (MOF) ZIF‐8 has the advantages of a large specific surface area and high stability. A new strategy for the assembly of amino acid dehydrogenase with peptide linker and for improving enzyme immobilization is proposed.RESULTSPeptide linker enhanced enzyme activity after immobilization by 138.7%, and maintained 81.2% of its initial activity after seven recycles. The stability of PheDH_1D02/ZIF‐8 was greatly enhanced at 70–80 °C and pH 10–11. The catalytic efficiency of PheDH_1D02/ZIF‐8 was also enhanced compared with PheDH_1C1D/ZIF‐8 and two free enzymes.CONCLUSIONSMetal ions coordinated with the peptide linker and reoriented immobilization of enzyme onto the MOF with high enzyme loading capacity were achieved. The mesoporous structure of PheDH_1D02/ZIF‐8 facilitates substrate diffusion. Combining the assembly of peptide linker and MOF immobilization is a simple, economical and efficient method for improving dehydrogenase stability. © 2021 Society of Chemical Industry (SCI).
Evaluation of aortic biomechanics in patients with aortic disease via imaging: A review
Authors: Wang Yanli , Gong Min 
Published: October 2021

AbstractAs a bridge between the heart and the arteries, the aorta plays an important role in the cardiovascular system. The morbidity and mortality of aortic disease are extremely high, which is a serious threat to human life. The biomechanical abnormality of the aorta is an important factor of a series of pathological changes in the aortic wall. At present, there are many imaging methods to evaluate the biomechanics of the aorta, which will benefit to the early diagnosis and treatment of aortic disease. In this review, we describe the application of various imaging methods and parameters in aortic disease.
Stability and accuracy of Engquist–Majda absorbing boundary condition for pseudo spectral time domain method
Authors: Güneş Ahmet , Saydam Talha , Aksoy Serkan 
Published: October 2021

AbstractLagrange polynomials based Chebyshev Pseudo Spectral Time Domain (L‐CPSTD) method is an accurate time domain solver for electromagnetic problems. It utilizes the Lagrange interpolation polynomials to expand electromagnetic fields. This global interpolation, which uses all field values on all of the grid points to calculate the value at a single point, provides spectral accuracy. However, absorbing boundary conditions (ABCs) must be applied for open space problems. Engquist–Majda ABC is an important one due to its simplicity. Characteristic variables (CVs) can be used to implement the ABCs. In this article, for the first time, stability and accuracy of the Engquist–Majda ABC are proved by using the CVs in the L‐CPSTD solution of Maxwell's equations. The theoretical findings are verified by using the matrix eigenvalue method and the reflection coefficient in one and two dimensional open space examples. The numerical result is also validated by an analytical and an FDTD solution of a parallel‐plate waveguide problem. The efficiency of the proposed ABC is clearly shown.
The inclusion of minority groups in tourism workforce: Proposition of an impression management framework through the lens of corporate social responsibility
Authors: Hon Alice H. Y. , Gamor Emmanuel 
Published: October 2021

AbstractIncluding minority groups in the tourism workforce through the lens of corporate social responsibility and the dignity of work has received less attention in the academic and industry narration. This results from limited knowledge, particularly, theoretical development, the how, and to what extent inclusion of minorities could improve firm image, and the attainment of the SDGs. This paper develops an impression management model along with nine propositions by including minority groups as CSR strategy and corporate image. It incorporates impression management theory and CSR approach and elaborates on implications to attain SDGs 8, 10, and 16 through tourism workforce inclusivity.
Justice and equity in pragmatic clinical trials: Considerations for pain research within integrated health systems
Authors: Ali Joseph , Davis Alison F. , Burgess Diana J. , Rhon Daniel I. , Vining Robert , Young‐McCaughan Stacey , Green Sean , Kerns Robert D. 
Published: October 2021

AbstractIntroductionPragmatic clinical trials (PCTs) can overcome implementation challenges for bringing evidence‐based therapies to people living with pain and co‐occurring conditions, providing actionable information for patients, providers, health systems, and policy makers. All studies, including those conducted within health systems that have a history of advancing equitable care, should make efforts to address justice and equity.MethodsDrawing from collective experience within pragmatic pain clinical trials networks, and synthesizing relevant literature, our multidisciplinary working group examined challenges related to integrating justice and equity into pragmatic pain management research conducted in large, integrated health systems. Our analysis draws from military and veteran health system contexts but offers strategies to consider throughout the lifecycle of pragmatic research more widely.ResultsWe found that PCTs present a unique opportunity to address major influences on health inequities by occupying a space between research, healthcare delivery, and the complexities of everyday life. We highlight key challenges that require attention to support complementary advancement of justice and equity via pragmatic research, offering several strategies that can be pursued.ConclusionsEfforts are needed to engage diverse stakeholders broadly and creatively in PCTs, such as through dedicated health equity working groups and other collaborative relationships with stakeholders, to support robust and inclusive approaches to research design and implementation across study settings. These considerations, while essential to pain management research, offer important opportunities toward achieving more equitable healthcare and health systems to benefit people living with pain and co‐occurring conditions.
A two‐layer cylinder phantom developed for film‐based isocenter verification of radiotherapy machine
Authors: Song Zhiyue , Yan Hui , Xu Yingjie , Dai Jianrong 
Published: October 2021

AbstractPurposeA two‐layer cylinder (TLC) phantom was developed for simplifying film‐based isocenter verification of linear accelerators in radiotherapy.Methods and materialsThe phantom mainly consists of two parts: (1) two nested solid cylinders between which a radiochromic film can be inserted and irradiated; (2) a tungsten ball supported by a thin rod and located at the phantom center for alignment with the mechanical isocenter. In practice, the phantom was first positioned by the room laser to align the tungsten ball to the mechanical isocenter of the linear accelerator. Then, a radiochromic film was precisely inserted into the gap between the two cylinders of the phantom and irradiated by beams with preset gantry and couch angles. Later the irradiated film was scanned and processed by an in‐house developed analysis software. Finally, the offset of the radiation isocenter from the mechanical isocenter was determined by the built‐in three‐dimensional (3D) reconstruction algorithms. The accuracy of this method was evaluated by positioning the phantom with a known couch shift, then checking the residual error after couch shift correction. The reliability of this method was evaluated by comparing the calculated offset with the corresponding result determined by the traditional star‐shot method.ResultsFor the accuracy test, the residual errors were −0.14 ± 0.03 mm, 0.05 ± 0.06 mm, and 0.05 ± 0.06 mm in the lateral, longitudinal, and vertical axes, respectively. For the reliability test, the differences between the calculated offset and the result determined by the star‐shot method were −0.10 mm, 0.12 mm, and 0.12 mm in the lateral, longitudinal, and vertical axes, respectively.ConclusionThe proposed method is able to reconstruct beams in 3D with one film, which is more time‐saving and accurate. Additionally, with this design, the phantom positioning, film loading, beam delivery, and data analyzing are simpler. This phantom and analysis software provides an efficient and effective way to perform film‐based isocenter verification of linear accelerators in radiotherapy.
A novel strategy to determine the optimal clamping force based on the clamping force change during injection molding
Authors: Xu Yuxuan , Liu Gang , Dang Kaifang , Fu Nanhong , Jiao Xiaolong , Wang Jinling , Xie Pengcheng , Yang Weimin 
Published: October 2021

AbstractInjection molding machines are widely used to fabricate plastic products with complex geometries and structures. They consist of an injection unit and a clamping unit. To withstand the pressure of the mold cavity, the clamping unit needs a high clamping force to hold the mold halves. Unfortunately, the clamping force is among the overlooked parameters of the injection molding parameters. Setting the clamping force at max is needed in practice to avoid flash defects for most operators. However, excessive clamping force creates problems for the machine. This study proposes a verification method for determining optimal clamping force based on the clamping force change ΔCF. When ΔCF becomes zero, the current set value of the clamping force is appropriate. A positive and negative ΔCF corresponds to an excessive and insufficient set value of the clamping force, respectively. Verification experiments are implemented on an electric injection molding machine with polypropylene (PP). The experimental results show that the novel strategy can basically calculate and identify the optimal clamping force with iteration method. The optimal clamping force value for current working conditions (620kN) is acquired after several automatic molding trials, which provides a direction for further research.
Chain‐growth branching radical polymerization: an inibramer strategy
Authors: Cao Mengxue , Zhong Mingjiang 
Published: October 2021

AbstractBranched polymers are considered as more synthetically scalable and accessible alternatives of dendrimers with similar properties such as low viscosity, high solubility, and high degree of end group functionality. However, traditional synthetic strategies towards branched polymers have limited control over molecular weight and degree of branching due to the step‐growth reaction mechanism of the branching polymerization. To achieve a better control over the branching polymerization, a chain‐growth controlled polymerization pathway can be realized by employing a rationally designed comonomer called inibramer (initiator + monomer + branching junction creator) where the initiating site is exclusively active after the monomer is polymerized. In this minireview, recent developments on inibramer design are reviewed. The directions for incorporating new types of inibramers to produce dendrimer‐like polymers and broaden their applications are discussed. © 2021 Society of Industrial Chemistry.
Registration of TifGP‐3 and TifGP‐4 peanut germplasm lines
Authors: Holbrook C. Corley , Ozias‐Akins Peggy , Chu Ye , Lamon Samuele , Bertioli David J. , Leal‐Bertioli Soraya C. M. , Culbreath Albert K. , Godoy Ignacio 
Published: October 2021

AbstractLate leaf spot (LLS) disease caused by Nothopassalora personata (Berk. & M.A. Curtis) U. Braun, C. Nakash, Videira & Crous is a foliar disease that plagues peanut (Arachis hypogaea L.) production worldwide. One effective solution to control this disease would be the development of resistant cultivars. IAC 322 is a breeding line resistant to LLS due to alien introgressions from A. cardenasii Krapov. & W.C. Gregory, a wild diploid relative of peanut. We crossed ‘TifNV‐High O/L’ with IAC 322 to develop a segregating breeding population. Two lines with very high levels of resistance to LLS were selected and genotyped. Line S07 (TifGP‐3, Reg. no. GP‐244, PI 698818) has introgressed segments from A. cardenasii on the top of chromosome A02, the bottom of A02, and the bottom of A03. Line S273 (TifGP‐4, Reg. no. GP‐245, PI 698819) has the introgressed segments on the top of A02 and the bottom of A03. The level of resistance to LLS observed in these two lines was not significantly different. Segments on the top of A02 combined with the bottom of A03 accounted for the majority of LLS resistance. Some breeders may choose to use TifGP‐4 to minimize the chance of linkage drag. However, important traits may reside in the segment on the bottom of A02, so we are also releasing TifGP‐3. KASPar assays can be used to determine the presence or absence of each introgressed segment, which will allow breeders to use marker‐assisted selection. These two germplasm lines were jointly released by the USDA‐ARS and University of Georgia in 2021.
Theoretical insights of solvent effect on tautomerism, stability, and electronic properties of 6‐ketomethylphenanthridine
Authors: Asadi Sara , Masoodi Hamid Reza , Mehrabi Hossein 
Published: October 2021

AbstractIn this manuscript, the influence of solvent on stability and electronic properties of enolimine, enaminone, and iminone forms of 6‐ketomethylphenanthridine is theoretically investigated using polarizable continuum model (PCM). Here, PCM is used during optimization of structures of tautomeric forms in solution. Water, ethanol, acetone, acetonitrile, chloroform, diethyl ether, dichloromethane, and dimethyl sulfoxide are chosen as solvent. The calculations are performed at M06‐2X/6‐311++G(d,p) level. In gas phase and in the solvents, the stability of tautomers increases as enaminone > enolimine > iminone. The topological properties of electron charge density are also studied for better understanding of stability of tautomers. It is observed that the stability of tautomers is diminished by increasing dielectric constant of solvent. Also, the increase in dielectric constant of solvent kinetically and thermodynamically facilitates the enolimine ⇌ enaminone tautomerization. To obtain more valuable information on stabilities of tautomers in water phase, the PCM calculations have also been performed with one water molecule. At M06‐2X/6‐311++G(d,p) level of theory, the stability of complexes is amplified as enaminone–water > iminone–water (V) > iminone–water (IV) > enolimine–water. The relationships between dielectric constant of solvent and some electronic properties of tautomers such as band gap, electron affinity, electrophilicity index, first ionization energy, electronic chemical potential, chemical softness, and hardness are also investigated.