bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronology and stratigraphy of the Imlay Channel in Lapeer County, Michigan, USA
Authors: Luczak Jonathan N. , Fisher Timothy G. , Lepper Kenneth 
Published: June 2021

The Imlay Channel in Lapeer County, Michigan, was one of two outlets for the glacial Lake Maumee phase of ancestral Lake Erie. Fifteen new radiocarbon and optical ages from within and adjacent to the Imlay Channel constrain sedimentation rates within the channel and the timing of regional deglaciation. For nearly 50 years, the deglaciation of this region of Michigan has been based on a single age from the Weaver Drain site located near the Imlay Channel, and a new radiocarbon age of 16.7–17.0 cal ka BP from 3 km east of the Imlay Channel supports this long-standing deglacial age. On average, there is a 14 m thick sediment fill within the channel. Radiocarbon and optically stimulated luminescence ages reveal that much of the alluvial fill was deposited by 14.9 ka, and alluvial fans building into the channel stabilized in the early Holocene. Cross-sections along and perpendicular to the Imlay Channel, built from geotechnical borings and water-well records, reveal a current-day bedrock sill elevation at 235 m a.s.l. that would have permitted drainage of all stages of glacial Lake Maumee in the past.
Targeting the Extracellular HSP90 Co-Chaperone Morgana Inhibits Cancer Cell Migration and Promotes Anticancer Immunity
Authors: Seclì Laura , Avalle Lidia , Poggio Pietro , Fragale Giuseppe , Cannata Cristiana , Conti Laura , Iannucci Andrea , Carrà Giovanna , Rubinetto Cristina , Miniscalco Barbara , Hirsch Emilio , Poli Valeria , Morotti Alessandro , De Andrea Marco , Turco Emilia , Cavallo Federica , Fusella Federica , Brancaccio Mara 
Published: June 2021

AbstractHSP90 is secreted by cancer cells into the extracellular milieu, where it exerts protumoral activities by activating extracellular substrate proteins and triggering autocrine signals through cancer cell surface receptors. Emerging evidence indicates that HSP90 co-chaperones are also secreted and may direct HSP90 extracellular activities. In this study, we found that the HSP90 co-chaperone Morgana is released by cancer cells and, in association with HSP90, induces cancer cell migration through TLR2, TLR4, and LRP1. In syngeneic cancer mouse models, a mAb targeting Morgana extracellular activity reduced primary tumor growth via macrophage-dependent recruitment of CD8+ T lymphocytes, blocked cancer cell migration, and inhibited metastatic spreading. Overall, these data define Morgana as a new player in the HSP90 extracellular interactome and suggest that Morgana may regulate HSP90 activity to promote cancer cell migration and suppress antitumor immunity.Significance:This work suggests the potential therapeutic value of targeting the extracellular HSP90 co-chaperone Morgana to inhibit metastasis formation and enhance the CD8+ T-cell–mediated antitumor immune response.
Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Authors: Tang Yuting , Xu Qian , Hu Liang , Yan Xiaomei , Feng Xiaomin , Yokota Asumi , Wang Weinan , Zhan Di , Krishnamurthy Durga , Ochayon David E. , Wen Lijun , Huo Li , Zeng Huimin , Luo Yingwan , Huang L. Frank , Wunderlich Mark , Zhang Jiwang , Vivier Eric , Zhou Jianfeng , Waggoner Stephen N. , Huang Gang 
Published: June 2021

Abstract

Natural killer (NK) cells and T cells are key effectors of antitumor immune responses and major targets of checkpoint inhibitors. In multiple cancer types, we find that the expression of Wnt signaling potentiator R-spondin genes (e.g., RSPO3) is associated with favorable prognosis and positively correlates with gene signatures of both NK cells and T cells. Although endothelial cells and cancer-associated fibroblasts comprise the R-spondin 3–producing cells, NK cells and T cells correspondingly express the R-spondin 3 receptor LGR6 within the tumor microenvironment (TME). Exogenous expression or intratumor injection of R-spondin 3 in tumors enhanced the infiltration and function of cytotoxic effector cells, which led to tumor regression. NK cells and CD8+ T cells independently and cooperatively contributed to R-spondin 3–induced control of distinct tumor types. The effect of R-spondin 3 was mediated in part through upregulation of MYC and ribosomal biogenesis. Importantly, R-spondin 3 expression enhanced tumor sensitivity to anti–PD-1 therapy, thereby highlighting new therapeutic avenues.

Significance:
Our study identifies novel targets in enhancing antitumor immunity and sensitizing immune checkpoint inhibition, which provides a rationale for developing new immunotherapies against cancers. It also offers mechanistic insights on Wnt signaling–mediated modulation of anticancer immunity in the TME and implications for a putative R-spondin–LGR6 axis in regulating NK-cell biology.
This article is highlighted in the In This Issue feature, p. 2945
Analysis of 3-Dimensional Arch Anatomy, Vascular Flow, and Postnatal Outcome in Cases of Suspected Coarctation of the Aorta Using Fetal Cardiac Magnetic Resonance Imaging
Authors: Lloyd David F.A. , van Poppel Milou P.M. , Pushparajah Kuberan , Vigneswaran Trisha V. , Zidere Vita , Steinweg Johannes , van Amerom Joshua F.P. , Roberts Thomas A. , Schulz Alexander , Charakida Marietta , Miller Owen , Sharland Gurleen , Rutherford Mary , Hajnal Joseph V. , Simpson John M. , Razavi Reza 
Published: June 2021

Background:
Identifying fetuses at risk of severe neonatal coarctation of the aorta (CoA) can be lifesaving but is notoriously challenging in clinical practice with a high rate of false positives. Novel fetal 3-dimensional and phase-contrast magnetic resonance imaging (MRI) offers an unprecedented means of assessing the human fetal cardiovascular system before birth. We performed detailed MRI assessment of fetal vascular morphology and flows in a cohort of fetuses with suspected CoA, correlated with the need for postnatal intervention.

Methods:
Women carrying a fetus with suspected CoA on echocardiography were referred for MRI assessment between 26 and 36 weeks of gestation, including high-resolution motion-corrected 3-dimensional volumes of the fetal heart and phase-contrast flow sequences gated with metric optimized gating. The relationship between aortic geometry and vascular flows was then analyzed and compared with postnatal outcome.

Results:

Seventy-two patients (51 with suspected fetal CoA and 21 healthy controls) underwent fetal MRI with motion-corrected 3-dimensional vascular reconstructions. Vascular flow measurements from phase-contrast sequences were available in 53 patients. In the CoA group, 25 of 51 (49%) required surgical repair of coarctation after birth; the remaining 26 of 51 (51%) were discharged without neonatal intervention. Reduced blood flow in the fetal ascending aorta and at the aortic isthmus was associated with increasing angulation (
P
=0.005) and proximal displacement (
P
=0.006) of the isthmus and was seen in both true positive and false positive cases. A multivariate logistic regression model including aortic flow and isthmal displacement explained 78% of the variation in outcome and correctly predicted the need for intervention in 93% of cases.

Conclusions:
Reduced blood flow though the left heart is associated with important configurational changes at the aortic isthmus in fetal life, predisposing to CoA when the arterial duct closes after birth. Novel fetal MRI techniques may have a role in both understanding and accurately predicting severe neonatal CoA.
Mediterranean Diet Score, Dietary Patterns, and Risk of Sudden Cardiac Death in the REGARDS Study
Authors: Shikany James M. , Safford Monika M. , Soroka Orysya , Brown Todd M. , Newby P. K. , Durant Raegan W. , Judd Suzanne E. 
Published: June 2021

Background
Sudden cardiac death (SCD) is a common cause of death in the United States. Few previous studies have investigated the associations of diet scores and dietary patterns with risk of SCD. We investigated the associations of the Mediterranean diet score and various dietary patterns with risk of SCD in participants in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study cohort.

Methods and Results

Diet was assessed with a food frequency questionnaire administered at baseline in REGARDS. The Mediterranean diet score was derived based on the consumption of specific food groups considered beneficial or detrimental components of that diet. Dietary patterns were derived previously using factor analysis, and adherence to each pattern was scored. SCD events were ascertained through regular contacts. Cox proportional hazards regression was used to examine the risk of SCD events associated with the Mediterranean diet score and adherence to each of the 5 dietary patterns overall and stratifying on history of coronary heart disease at baseline. The analytic sample included 21 069 participants with a mean 9.8±3.8 years of follow‐up. The Mediterranean diet score showed a trend toward an inverse association with risk of SCD after multivariable adjustment (hazard ratio [HR] comparing highest with lowest group, 0.74; 95% CI, 0.55–1.01;
P
trend
=0.07). There was a trend toward a positive association of the Southern dietary pattern with risk of SCD (HR comparing highest with lowest quartile of adherence, 1.46; 95% CI, 1.02–2.10;
P
trend
=0.06).

Conclusions
In REGARDS participants, we identified trends toward an inverse association of the Mediterranean diet score and a positive association of adherence to the Southern dietary pattern with risk of SCD.
Sex Differences in Stroke Care and Outcome 2005–2018
Authors: Eriksson Marie , Åsberg Signild , Sunnerhagen Katharina Stibrant , von Euler Mia ,   on behalf of the Riksstroke Collaboration
Published: June 2021

Background and Purpose:
Previous studies of stroke management and outcome in Sweden have revealed differences between men and women. We aimed to analyze if differences in stroke incidence, care, and outcome have altered over time.

Methods:
All stroke events registered in the Swedish Stroke Register 2005 to 2018 were included. Background variables and treatment were collected during the acute hospital stay. Survival data were obtained from the national cause of death register by individual linkage. We used unadjusted proportions and estimated age-adjusted marginal means, using a generalized linear model, to present outcome.

Results:
We identified 335 183 stroke events and a decreasing incidence in men and women 2005 to 2018. Men were on average younger than women (73.3 versus 78.1 years) at stroke onset. The age-adjusted proportion of reperfusion therapy 2005 to 2018 increased more rapidly in women than in men (2.3%–15.1% in men versus 1.4%–16.9% in women), but in 2018, women still had a lower probability of receiving thrombolysis within 30 minutes. Among patients with atrial fibrillation, oral anticoagulants at discharge increased more rapidly in women (31.2%–78.6% in men versus 26.7%–81.9% in women). Statins remained higher in men (36.9%–83.7% in men versus 32.3%–81.2% in women). Men had better functional outcome and survival after stroke. After adjustment for women’s higher age, more severe strokes, and background characteristics, the absolute difference in functional outcome was <1% and survival did not differ.

Conclusions:
Stroke incidence, care, and outcome show continuous improvements in Sweden, and previously reported differences between men and women become less evident. More severe strokes and older age in women at stroke onset are explanations to persisting differences.
The Taxonomy of Writing Systems: How to Measure How Logographic a System Is
Authors: Sproat Richard , Gutkin Alexander 
Published: June 2021

Taxonomies of writing systems since Gelb (1952) have classified systems based on what the written symbols represent: if they represent words or morphemes, they are logographic; if syllables, syllabic; if segments, alphabetic; and so forth. Sproat (2000) and Rogers (2005) broke with tradition by splitting the logographic and phonographic aspects into two dimensions, with logography being graded rather than a categorical distinction. A system could be syllabic, and highly logographic; or alphabetic, and mostly non-logographic. This accords better with how writing systems actually work, but neither author proposed a method for measuring logography.In this article we propose a novel measure of the degree of logography that uses an attention-based sequence-to-sequence model trained to predict the spelling of a token from its pronunciation in context. In an ideal phonographic system, the model should need to attend to only the current token in order to compute how to spell it, and this would show in the attention matrix activations. In contrast, with a logographic system, where a given pronunciation might correspond to several different spellings, the model would need to attend to a broader context. The ratio of the activation outside the token and the total activation forms the basis of our measure. We compare this with a simple lexical measure, and an entropic measure, as well as several other neural models, and argue that on balance our attention-based measure accords best with intuition about how logographic various systems are.Our work provides the first quantifiable measure of the notion of logography that accords with linguistic intuition and, we argue, provides better insight into what this notion means.
Sustained Attention and Spatial Attention Distinctly Influence Long-term Memory Encoding
Authors: deBettencourt Megan T. , Williams Stephanie D. , Vogel Edward K. , Awh Edward 
Published: June 2021

Abstract
Our attention is critically important for what we remember. Prior measures of the relationship between attention and memory, however, have largely treated “attention” as a monolith. Here, across three experiments, we provide evidence for two dissociable aspects of attention that influence encoding into long-term memory. Using spatial cues together with a sensitive continuous report procedure, we find that long-term memory response error is affected by both trial-by-trial fluctuations of sustained attention and prioritization via covert spatial attention. Furthermore, using multivariate analyses of EEG, we track both sustained attention and spatial attention before stimulus onset. Intriguingly, even during moments of low sustained attention, there is no decline in the representation of the spatially attended location, showing that these two aspects of attention have robust but independent effects on long-term memory encoding. Finally, sustained and spatial attention predicted distinct variance in long-term memory performance across individuals. That is, the relationship between attention and long-term memory suggests a composite model, wherein distinct attentional subcomponents influence encoding into long-term memory. These results point toward a taxonomy of the distinct attentional processes that constrain our memories.
Least kth-Order and Rényi Generative Adversarial Networks
Authors: Bhatia Himesh , Paul William , Alajaji Fady , Gharesifard Bahman , Burlina Philippe 
Published: June 2021

Abstract
We investigate the use of parameterized families of information-theoretic measures to generalize the loss functions of generative adversarial networks (GANs) with the objective of improving performance. A new generator loss function, least kth-order GAN (LkGAN), is introduced, generalizing the least squares GANs (LSGANs) by using a kth-order absolute error distortion measure with k≥1 (which recovers the LSGAN loss function when k=2). It is shown that minimizing this generalized loss function under an (unconstrained) optimal discriminator is equivalent to minimizing the kth-order Pearson-Vajda divergence. Another novel GAN generator loss function is next proposed in terms of Rényi cross-entropy functionals with order α&gt;0, α≠1. It is demonstrated that this Rényi-centric generalized loss function, which provably reduces to the original GAN loss function as α→1, preserves the equilibrium point satisfied by the original GAN based on the Jensen-Rényi divergence, a natural extension of the Jensen-Shannon divergence.
Experimental results indicate that the proposed loss functions, applied to the MNIST and CelebA data sets, under both DCGAN and StyleGAN architectures, confer performance benefits by virtue of the extra degrees of freedom provided by the parameters k and α, respectively. More specifically, experiments show improvements with regard to the quality of the generated images as measured by the Fréchet inception distance score and training stability. While it was applied to GANs in this study, the proposed approach is generic and can be used in other applications of information theory to deep learning, for example, the issues of fairness or privacy in artificial intelligence.
On Virtue and Reason: Integrative Theory of De 德 and Aretê
Authors: Cheng Chung-ying 
Published: June 2021

Abstract
This article is to argue that virtue is experienced and understood in Confucian ethics as power to act and as performance of a moral action, and that virtue (de 德) as such has to be onto-cosmologically explicated, not just teleologically explained. In other words, it is intended to construct an integrative theory of virtues based on both dao (the Way 道) and de. To do so, we will examine the two features of de, as the power that is derived from self-reflection and self-restraining, and as the motivated action for attaining its practical end in a community. Only by a self-integrated moral consciousness can one’s experience, action and ideal remain in consistency and coherence, which leads us to the Aristotelian notion of virtue as excellence (aretê) and enables us to see how virtue as aretê could be introduced as a second feature of de, namely as the power for effective action in the whole system of virtues, apart from the first feature of de as self-restraining power. We will conclude that reason and virtue are practically united and remain inseparable, and that taking into account the onto-cosmological foundation of virtues, reason and virtue are inevitably the moving and advancing forces for the formation and transformation of human morality just as they are motivating and prompting incentives for individual moral action.
“Please Give Me My Voice”: Women’s Out-of-Court Divorce in a Secondary City in Senegal
Authors: Bouland Annelien 
Published: June 2021

Abstract
Divorce is not uncommon among Muslims in Senegal and tends to take place outside of court, even if the Senegalese Family Code has made out-of-court divorce illegal. Yet little is known about how women in particular may obtain divorce outside of the court. This article provides ethnographic material on the way women divorce out-of-court, and the repertoires of justification they draw on. In line with scholarly work on women’s use of Islamic courts in other countries the article foregrounds women’s agency, yet in a different out-of-court context. First, it is shown that women draw on multiple, gendered, repertoires. Second, it is argued that because family members play a central role in the divorces studied, the analysis of women’s agency requires an attentiveness to kin and women’s “kinwork”.
Multidecadal Variations in the East Asian Winter Monsoon and Their Relationship with the Atlantic Multidecadal Oscillation since 1850
Authors: Miao Jiapeng , Jiang Dabang 
Published: June 2021

AbstractThis study investigates the characteristics and physical mechanisms of the multidecadal variations in the East Asian winter (December–February) monsoon (EAWM) since 1850 based on multiple observational and reanalysis datasets. The results indicate that the EAWM undergoes multidecadal weakening during the periods of 1869–1919 and 1986–2004 but strengthening during the period of 1920–85. Similar evolutions can be observed in the time series of the area-averaged winter surface air temperature over East Asia. Associated with the EAWM multidecadal variations, a quasi-barotropic Rossby wave train originating from the subtropical North Atlantic propagating across the Eurasian continent to Northeast Asia also experiences phase shifting at the same time. In its positive phase, the low-level anticyclonic anomaly over the northern Eurasian continent causes a stronger Siberian high; the mid- and high-level cyclonic anomalies over Northeast Asia deepen the East Asian trough and strengthen the East Asian jet stream, respectively. Thus, the positive phase of the wave train is conducive to stronger EAWMs and vice versa. The diagnostic analysis of the Rossby wave source indicates that the upper-tropospheric divergence anomalies over the North Atlantic can favor the excitation of this wave train, and the feedback forcing of high-frequency eddies plays important roles in its maintenance. In addition, the phase shifting of the Atlantic multidecadal oscillation (AMO) can induce a similar Rossby wave train across the Eurasian continent, through which it further modulates the multidecadal variations in the EAWM. Warm phases of the AMO are favorable for a stronger EAWM and colder midlatitude Eurasian continent and vice versa.
‘Give them air quickly – don’t let them out’: Sentencing for manslaughter involving multiple offenders and victims
Authors: Roberts Julian V 
Published: June 2021

Sentencing for multiple offences poses many challenges and becomes even more complex when the crimes resulted in fatalities. This article uses the sentences imposed following convictions in the Essex lorry case to pose some general questions about the sentencing of multiple victim manslaughters. The four principal offenders were convicted of 39 counts of unlawful act manslaughter and conspiracy to facilitate unlawful immigration into the UK. The analysis identifies several ways in which the sentences ultimately imposed failed to adequately distinguish between offenders of very different levels of culpability. First, all four principal offenders were assigned to the same level of culpability in the manslaughter guideline. Second, although the court could have distinguished the offenders to reflect their different culpability levels, the same Starting Point sentence was imposed on all offenders. Third, the sentencing uplifts to reflect the multiple counts were similar across offenders of very different culpabilities. Fourth, the differential additional punishments for the conspiracy conviction — which would have separated the offenders’ time in custody further — were washed out by being made concurrent. As a result of these decisions, the final sentences failed to adequately distinguish between offenders of very different culpabilities. The article concludes with some lessons for sentencing in these cases, specifically with respect to the Sentencing Council’s guidelines.