bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Emergence of ADHD Comorbidity in School-Aged Children with ASD Impacts Resting-State Brain Networks Dynamics
Authors: Bochet Aurélie , Journal Fiona , Sperdin Holger Franz , Schaer Marie 
Published: December 2021

Abstract
Background: EEG microstates are defined in the literature as quasi-stable topographies of the electric fields in the ongoing EEG, lasting approximately 100 milliseconds and representing the sub-second coherent activation within global functional brain networks. Recently, we found early alterations in the spatio-temporal dynamics and syntax of brain states in toddlers and preschoolers with autism spectrum disorders (ASD) compared to their typically developing (TD) peers.Method: Here, we investigated how these alterations evolve over time and how they are impacted by the emergence of comorbid attention deficit/hyperactivity disorder (ADHD) in ASD among 49 school-aged children (19 children with ASD-only, 15 children with ASD+ADHD, and 15 TD children). Results: We found a decreased prevalence of all temporal parameters of microstate map B in school-aged children with ASD compared to TD peers. Children with ASD+ADHD had a significantly lower prevalence of map B compared to children with ASD-only. Moreover, children with ASD+ADHD had a higher prevalence in time coverage and occurrence for microstate map A than children with ASD-only and TD children. Map E of the ASD+ADHD group has a weaker spatial correlation with map E of ASD-only and TD groups. Moreover, the GEV of map E was significantly decreased for the ASD+ADHD group compared to the ASD-only group. We found that the transition probabilities between maps of the ASD+ADHD group, particularly for map B, differed from ASD-only and TD groups. Exploratory longitudinal analysis showed an increase in all temporal parameters of map B in TD children but a decrease in children with ASD, regardless of the ADHD comorbidity.Limitations: The present study has a small sample size and does not include a group of children with ADHD-only. Conclusion: Our results show that ADHD comorbidity in school-aged children with ASD impacts the spatial organization and the temporal dynamics of whole-brain networks. Further longitudinal studies are needed to understand better the impact of the emergence of ADHD comorbidity in ASD across ages.
Limitations in Activities of Daily Living in Individuals With Chronic Kidney Disease: Biopsychosocial Factors of the Brazilian Population
Authors: Lima Hellen Carvalho , Dantas Carla Daniele Ferreira , Santos Adson Aragão Araújo , Tenório Adirlene Pontes Oliveira , Guedes Marcello Barbosa Otoni Gonçalves , Guedes Thais Sousa Rodrigues , Lopes Matheus Rodrigues , Souza Clecio Gabriel , Pegado Rodrigo , Lopes Johnnatas Mikael 
Published: December 2021

Abstract
This study assesses the relationship between biopsychosocial factors and limitations in activities of daily living (ADL) in individuals with chronic kidney disease (CKD). Individual data from the National Health Survey were analyzed, with a sample size of 839 participants. The outcome was dichotomous, presenting limitations in ADL, and the factors considered were clinical and health characteristics, self-perceived behavior, contextual social support, and housing. Cox regression was applied to control the interaction between factors, using the prevalence ratio as a measure of effect and a significance level of 5%. A total of 839 individuals with CKD were reported, of which 373 (40.7%: 35.4 - 46.1%) reported having limitations in ADL. The presence of limitations in ADL was related to residing in a rural area, as well as to the absence of private health insurance, worse self-perceived health, presence of depressive symptoms, and disabilities, in addition to the use of medications and hemodialysis. Limitations in ADL in individuals with CKD are associated with biopsychosocial factors in the Brazilian population, requiring public policies that enable better therapeutic management and support for behavioral health and contextual needs.
The Power of Many: A Physarum Swarm Steiner Tree Algorithm
Authors: Schaposnik Laura P. , Hsu Sheryl , Massolo Fidel I. Schaposnik 
Published: December 2021

Abstract
This paper presents a novel explore-and-fuse approach to solving a large array of problems that cannot be solved by traditional divide-and-conquer. This approach is inspired by Physarum, a unicellular slime mold capable of solving the traveling salesman and Steiner tree problems. Besides exhibiting individual intelligence, Physarum can also share information with other Physarum organisms through fusion. Inspired by the characteristics of Physarum, we spawn many Physarum organisms to explore the problem space in parallel, each gathering information and forming partial solutions pertaining to a local region of the problem space. When the organisms meet, they fuse and share information, eventually forming one organism which has a global view of the problem and can apply its intelligence to find an overall solution to the problem. We demonstrate this novel approach on the NP-hard Steiner tree problem, developing the Physarum Steiner Algorithm. This algorithm is of particular interest due to its ability to leverage parallel processing, avoid obstacles, and operate on various shapes and topological surfaces including the rectilinear grid.
Lipidic Profiles of Patients Starting Peritoneal Dialysis Suggest an Increased Cardiovascular Risk Beyond Classical Dyslipidemia Biomarkers
Authors: Lluesa Julia Hernández , López-Romero Luis Carlos , Broseta José Jesús , Marugán Marta Roca , Boyano Iris Viejo , Rodríguez-Espinosa Diana , Gómez-Bori Aina , Orient Amparo Soldevila , Devesa-Such Ramón , Perez Pilar Sánchez , Hernández-Jaras Julio 
Published: December 2021

Abstract
Background. Lipids are molecules that constitute a fundamental part of the plasma. Chronic kidney disease (CKD) produces profound changes in lipid metabolism, and associated lipid disorders, in turn, contribute to the progression of CKD. Patients on peritoneal dialysis (PD) have more atherogenic lipid profiles than non-dialysis-dependent CKD patients. Methods. Single-center prospective observational study of a cohort of CKD patients who started renal replacement therapy with continuous ambulatory peritoneal dialysis. The differences in the lipid profile and analytical variables before and six months after the start of peritoneal dialysis were analyzed. Samples were analyzed on an Ultra-Performance Liquid Chromatography system. Results. Thirty-nine patients were enrolled in this study. Their mean age was 57.9 ± 16.3 years. A total of 157 endogenous lipid species of 11 lipid subclasses were identified. There were significant increases in total free fatty acids (p< 0.05), diacylglycerides (p <0.01), triacylglycerides, (p <0.01), phosphatidylcholines (p <0.01), phosphatidylethanolamines (p <0.01), ceramides (p <0.01), sphingomyelins (p <0.01), and cholesterol esters (p<0.01) from baseline to 6 months. However, there were no differences in the classical lipid markers, neither lysophosphatidylcholines, monoacylglycerides, and sphingosine levels. Conclusions. Patients on PD present changes in the lipidomic profile beyond the classic markers of dyslipidemia, that suggest an increased cardiovascular risk in them.
Lamivudine, a Reverse Transcriptase Inhibitor, Rescues Cognitive Deficits in a Mouse Model of Down Syndrome
Authors: de Lagran Maria Martinez , Elizalde-Torrent Aleix , Paredes Roger , Clotet Bonaventura , Dierssen Mara 
Published: December 2021

Abstract
An elevated activity of retrotransposons is increasingly recognized to be implicated in a wide range of neurodegenerative and neurodevelopmental diseases. Down syndrome (DS) is the most common genetic disorder associated with intellectual disability and a genetic form of Alzheimer’s disease. For this reason, we hypothesized that treatment with reverse transcriptase inhibitors could ameliorate DS phenotypes. In this proof of concept study, we treated trisomic (Ts65Dn) mice, a model of DS, with lamivudine, a reverse transcriptase inhibitor. We detected a significant improvement of neurobehavioral phenotypes, and a complete rescue of the hippocampal-dependent recognition memory upon treatment with lamivudine. Despite clinical studies in patients with DS are warranted, this study lays the groundwork for a novel and actionable therapeutic approach.
Effect of Soil Water Contents on Arsenic Accumulation in Phytoliths of Pteris Multifida and Phragmites Australis
Authors: Min Hyun-Gi , Kim Min-Suk , Kim Jeong-Gyu 
Published: December 2021

Abstract
Purpose: The encapsulation of toxic metal(loid)s in phytoliths represents a new area of research. The accumulation of metal(loid)s in phytoliths can alter the fate and toxicity of soil metal(loid). Pteris multifida is a well-known As hyperaccumulator which also harbors phytoliths. However, As accumulation in phytoliths has not yet been studied. Soil water content is considered the main factor influencing phytolith accumulation and also remains unexplored with respect to As accumulation in phytoliths. In this study, As concentration in the phytoliths of P. multifida was compared with that in Phragmites australis phytoliths as a function of the soil water content. Methods: P. multifida and P. australis were grown under different soil water contents. The As concentration in phytoliths, roots, and shoots of plants was then determined.Results: The range of As concentration in the phytoliths of P. multifida was 414.70 - 1610.74 mg kg-1, and that for P. australis phytoliths was 41.67 - 126.54 mg kg-1. In P. multifida, higher soil water content increased As accumulation in phytoliths but did not affect phytolith content in the plant. In P. australis, the higher soil water content increased phytolith content in the plant but decreased As concentration in phytoliths. Conclusion: This study suggests that P. multifida has higher As content in phytoliths than P. australis, and this accumulation can be affected by soil water content. The current findings provide insight into the accumulation of As in phytoliths and provide a theoretical basis for our understanding on the fate of As in the environment.
Water-drinking Test in Normal Tension Glaucoma Patients with and without High Myopia
Authors: Chen Alexander , Kuo Ming-Tse , Lin Pei-Wen 
Published: December 2021

Abstract
This prospective study aims to evaluate the correlation between myopic severity and normal tension glaucoma (NTG) by investigating IOP changes following water-drinking test (WDT). We reviewed 61 patients with NTG during an interval of three years, of which 31 were highly myopic (HM) and 30 were non-highly myopic (NHM). Basic characteristics such as age, gender, spherical equivalence, baseline IOP, visual field parameters, and average retinal nerve fiber layer thickness were compared between NTG patients with and without high myopia. The IOP parameters obtained following WDT were then compared between the HM and NHM NTG groups. Intragroup analysis revealed significant IOP elevation following WDT within the 45-minute duration in both groups. However, no significant differences in IOP parameters were observed between the HM and NHM NTG groups. In conclusion, although the pattern of IOP fluctuations was different, the extent of IOP fluctuations and peak IOP following WDT was similar between the HM and NHM NTG groups, suggesting that myopic severity probably has a limited role in NTG. Lastly, WDT was an effective tool for eliciting IOP peaks when 24-hour IOP monitoring is not available.
The Ameliorative Effect of Lactobacillus Paracasei BEJ01 Against FB1 Induced Spermatogenesis Disturbance, Testicular Oxidative Stress and Histopathological Damage
Authors: EZDINI Khawla , salah-Abbès Jalila Ben , Belgacem Hela , chaieb kamel , Abbès Samir 
Published: December 2021

Abstract
Fumonisin B1 (FB1) was a possible carcinogenic molecule for humans as classified by the IARC on 2B group. In livestock, it was responsible for several mycotoxicosis and economic losses. Lactobacillus strains, inhabitants of a wide range of foodstuffs as well as our gastro-intestinal tract, were Generally Recognized as Safe (GRAS). Thus, the aim of this work was to evaluate the protective effect of Lactobacillus paracasei (LP) against FB1 induced reprotoxicities including testicular histopathology, sperm quality disturbance and testosterone level reduction. Pubescent mice were divided randomly into four groups as bellow: Group1: Control; Group 2: FB1 (100 µg/kg b.w); Group 3: LP (2× 109 CFU/kg b.w); Group 4: LP (2× 109 CFU/kg b.w) and FB1 (100 µg/kg b.w) to be then treated for 10 days. After the end of the treatment, animals were sacrificed; the plasma and epididyms and testicles were harvested to the reproductive system studies. Our results highlighted that LP counteracted the harmful effect generated by FB1. Indeed; it induced sperm quality reduction, oxidative stress generation and histological alterations. In conclusion, the used strain was able to prevent FB1-reproductive system damages of in balb/c mice and could be valorised as an anti-cating agent in animal FB1-contaminated diet.
Gadolinium-Based Nanoparticles Combined With Checkpoint Blockade Amplify Radiation-Induced Abscopal Effect And Cancer Immunotherapy
Authors: Song Huijuan , He Ningning , Xu Chang , Wang Yan , Du Liqing , Liu Yang , Wang Qin , Ji Kaihua , Wang Jinhan , Zhang Manman , Gu Yeqing , Zhang Yumin , Wang Weiwei , Tillement Olivier , Feng Li , Liu Qiang 
Published: December 2021

Abstract
Both immunotherapy checkpoint blocking and radiotherapy used alone in solid tumors show limited anticancer effect, due to the insufficient T cells infiltration and rarely elicited systemic immune responses. Methods: AGuIX has recently been developed for magnetic resonance imaging-guided radiotherapy and proven to act as an efficient radiosensitizer. In order to further improve the efficiency of tumor treatment, a unique synergistic strategy based on Gadolinium-based nanoparticles-AGuIX mediated radiotherapy and immunotherapy checkpoint blocking was developed for B16 tumor therapy in the present study. Clone formation, cell apoptosis and immunofluorescence were performed to detect the radiosensitization effect of AGuIX nanoparticles. The therapeutic effect was validated in both abscopal and metastasis tumor models, and analyzed the synergistic mechanism in vivo. Results: AGuIX as a radiosensitizer exacerbated radiation-induced DNA damage, cell cycle arrest and apoptosis on B16 cells. More importantly, it could efficiently induce the immunogenic cell death (ICD) of irradiated B16 tumor cells, and consequently triggered the maturation of dendritic cells (DCs) and activated systemic T-cell responses. Combining AGuIX-mediated radiotherapy with programmed cell death protein 1 (PD1) blocking demonstrated excellent synergistic therapeutic effects in both abscopal and metastasis tumor models by a significant increase in the infiltration of effector CD8+ T cells and effectively alleviating the immunosuppressive microenvironment, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in tumors.Conclusion: Our findings indicate that this combination therapy provided a new and powerful immunotherapy model to achieve durable anti-tumor responses, which is likely to be a promising comprehensive treatment strategy for cancer treatment.
Automated VHF-Radio Telemetry Reveals Resource-Driven Site Utilisation Patterns in a Small-Bodied, Highly Mobile Bird (Erythrura Gouldiae)
Authors: Hayward-Brown Brittany K , Crewe Tara L , Collett Sydney J , Udyawer Vinay , Radford Ian J , Campbell Mariana A , Campbell Hamish A 
Published: December 2021

Abstract
BackgroundInformation on site utilisation and movement is essential for managing species' resource requirements. Collecting these data requires frequent location sampling of multiple individuals, which can be challenging for small-bodied animals due to the often-large size of animal-borne satellite-based telemetry devices. We show how coded VHF-radio nano-transmitters and an array of passive receivers to collect location data at sufficient frequency and accuracy can be utilised to test whether the highly mobile and small-bodied Gouldian finch adheres to optimal foraging theory within a landscape of high spatiotemporal heterogeneity.MethodsCoded VHF-radio nano-transmitters (0.23 g wt.) were attached to 38 Gouldian finches (Erythrura gouldiae; < 12g bd. wt). Tagged birds were then detected by an array of 6 passive VHF-radio receivers (~ 530 m detection range) spread over 120 km2. We tracked the tagged birds during two sessions corresponding with high and low abundance of their primary food resource (Sorghum spp. seed). The mean and total duration that an individual spent within any receiver detection field (residence time) were used as dependants in a generalised linear mixed model approach within a Bayesian framework to assess the influence of tracking session, life stage, receiver site, and release site. Network analysis revealed the importance of specific areas for the finches within the receiver array using the proportional time a bird spent within any receiver's detection field and the movement between adjacent detection fields. ResultsThe daily mean and total duration that a tagged individual spent within a receiver detection field decreased by ~50% between periods of high and low seed availability, while the extent of movements across the landscape increased with a decline in seed resources. These data support the hypothesis that the Gouldian finch adheres to optimal foraging theory to survive periods of food scarcity. ConclusionsThe data collected via passive telemetry technology support the hypothesis that the Gouldian finch adheres to optimal foraging theory and uses alternative behavioural strategies to survive periods of food scarcity. Specifically, we found that Gouldian finches reduced the time spent foraging within a patch, increased the frequency of transit flights among patches, and expanded the size of their activity space as grass resources declined.
Genetic Genealogy Uncovers a Founder Deletion Mutation in the Cerebral Cavernous Malformations 2 Gene
Authors: Gallione Carol J , Detter Matthew R , Christmas Henrietta M , Lee Cornelia , Marchuk Douglas A 
Published: December 2021

Abstract
Cerebral cavernous malformations (CCM) are vascular malformations consisting of collections of enlarged capillaries occurring in the brain or spinal cord. These vascular malformations can occur sporadically or susceptibility to develop these can be inherited as an autosomal dominant trait due to mutation in one of three genes. Over a decade ago, we described a 77.6 Kb germline deletion spanning exons 2-10 in the CCM2 gene found in multiple affected individuals from seemingly unrelated families. Segregation analysis using linked, microsatellite markers indicated that this deletion may have arisen at least twice independently. In the ensuing decades, many more CCM patients have been identified with this deletion. In this present study we examined 27 reportedly unrelated affected individuals with this deletion. To investigate the origin of the deletion at base pair level resolution, we sequenced approximately 10 Kb upstream and downstream from the recombination junction on the deleted allele. All patients showed the identical SNP haplotype across this combined 20 Kb interval. In parallel, genealogical records have traced 11 of these individuals to five separate pedigrees dating as far back as the 1600-1700’s. These haplotype and genealogical data suggest that these families and the remaining “unrelated” samples converge on a common ancestor due to a founder mutation occurring centuries ago on the North American continent. We also note that another gene, NACAD, is included in this deletion. Although patient self-reporting does not indicate an apparent phenotypic consequence for heterozygous deletion of NACAD, further investigation is warranted for these patients.
Coronavirus Stress and Overeating: The Mediating Role of Anxiety and the Moderating Role of COVID-19 Burnout
Authors: Wang Ruining , Ye Baojuan , Yang Qiang 
Published: December 2021

Abstract
Background: This study examined the mediating effect of anxiety and the moderating effect of COVID-19 burnout on the relationship between coronavirus stress and overeating among Chinese college students during the COVID-19 period. Methods: 2926 Chinese students (Mage = 19.90, SD = 1.47, range = 18 - 25, 54.3% female) completed self-reported questionnaires regarding coronavirus stress, anxiety, overeating, and COVID-19 burnout. The data was analyzed using Pearson’s r correlations and moderated mediation analysis. Results: The results revealed that anxiety mediated the link between coronavirus stress and college students’ overeating. College students’ COVID-19 burnout moderated the associations between anxiety and college students’ overeating. The association between coronavirus stress and anxiety was stronger for those with higher COVID-19 burnout. Discussion and conclusion: Findings of this study demonstrated that coronavirus stress was positively related to anxiety, which in turn, was related to overeating in college students. COVID-19 burnout enhanced this effect at indirect mediation paths, suggesting that college students with greater COVID-19 burnout may be more likely to have overeating behavior. This study identified the critical factors associated with overeating; it supplies empirical support for existing theories and provides practical implications for interventions aiming to decrease Chinese college students’ overeating during COVID-19 period.
AI-Based Decision System to Evaluate Scenarios of Response to the COVID-19 Pandemic. Evidence From Barcelona and Manhattan
Authors: Grimaldi Didier , Arboleda Hugo , Esqui Karla 
Published: December 2021

Abstract
In 2020, the COVID-19 outbreak has had severe economic and social consequences all over the planet. Traditional national health systems have been unable to predict and to provide a decision support system able to coordinate an effective response to the outbreak and to stop the rapid spread of this disease. In this current manuscript, we have decided to focus our analysis on Small and Medium Businesses (SMBs). While some SMBs have survived, many others, particularly in urban areas, have had to shut down as a direct decision of government restrictions. Our study presents a decision support system based on Artificial Intelligence which helps governments to prioritize the closures of SMBs located in a city. Indeed, the decision to shut down may vary according to the relative danger that the business premises represent as a social gathering point and its benefits for the local economy. In this vein, we analyse 3 different scenarios which assume different financial and social costs. The visualization of the results on a city map provides additional value for the decision-making process. The Urban Decision Support System is tested by two case studies: Barcelona and New York City. This research has implications for practitioners to support their decision to close-down the economies in the event of another large-scale outbreak. It has also research implications as new evidence that data analytics could be an additional and valuable source of information for decision support processes.