bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persepsi Petani Terhadap Kinerja Penyuluh Pertanian di Desa Torongrejo Kecamatan Junrejo Kota Batu
Authors: Feliyana Chindy , Ibrahim Jabal Tarik , Ningsih Gumoyo Mumpuni 
Published: November 2021

Forest management carried out by the Panti District community in The performance of agricultural extension workers is starting to be felt by farmers, but in terms of farmers' perceptions of the performance of agricultural extension workers which are considered less than optimal because in the implementation of the extension there are obstacles such as differences in schedules between agricultural extension workers and farmer groups, many group members do not participate in extension activities. this. Regarding these obstacles, it is necessary to conduct a more in-depth study of farmers' perceptions of the performance of agricultural extension workers in Torongrejo Village, Junrejo District, Batu City. This study aims to analyze farmers' perceptions and the factors that influence farmers' perceptions of the performance of agricultural extension workers in Torongrejo Village, Junrejo District, Batu City. The technique of determining respondents in this study was simple random sampling. The number of respondents as many as 50 people is calculated based on the slovin formula. Data were collected by means of observation, interviews, questionnaires, and documentation. The analytical method used is Multiple Linear Regression with the help of SPSS (Software Program for Social Science) software. ). The ordinal scale data is converted to an interval scale with MSI (Methode of Successive Interval). Before the multiple linear regression analysis was tested, the classical assumption test, normality test, heteroscedasticity test and multicollinearity test were carried out. Based on the results of the analysis of the level of perception of farmers on the performance of the instructor as an initiator of 76%, as a motivator by 78%, as an educator by 78%, as a communicator by 79% and as a facilitator by 75% so that it can be said that the role that has been carried out by agricultural extension workers is categorized as good. The performance of agricultural instructors as initiators, motivators, educators, communicators and facilitators significantly influences the level of farmers' perceptions of the performance of agricultural extension workers.
Keywords : Perception, Farmer, Performance, Extension
Detection of Salmonella sp. on Bulk Meatballs and Packaged Meatballs at Sepanjang Market, Sidoarjo
Authors: Zain Rahmania , Hidanah Sri , Damayanti Ratna , Warsito Sunaryo Hadi 
Published: November 2021

Background: Bacterial contamination in food can cause congenital diseases in the form of infections. Meatballs are one of the foods that are in demand by the public and foods that can be contaminated with salmonella bacteria. Detection of Salmonella sp bacteria can determine the quality of bulk meatballs and packaged meatballs. Salmonella sp bacteria should not contaminate the meatballs according to the quality requirements of the BSNI (Badan Standarisasi Nasional Indonesia). Purpose: To determine the contamination of Salmonella sp bacteria in bulk meatballs and packaged meatballs sold at Sepanjang market, Taman District, Sidoarjo Regency. Methods: The Salmonella sp. test on meatballs was carried out in four stages, pre-enrichment using Buffered Pepthone Water solution, enrichment using Tetrathionate Brothbase solution, isolation using Salmonella Shigella Agar media, and biochemical testing using Triple Sugar Iron Agar media. The samples used were 10 samples each. Result: The test proved that 20% of the samples were positively contaminated with Salmonella sp. both on bulk meatballs and on packaged meatballs. Conclusion: Food hygiene and sanitation must be applied properly and correctly in every process because food products circulating in public, especially meatball products, can avoid microbial contamination and be safe for consumption.
PENINGKATAN NILAI EKONOMIS DAN DAYA SAING PRODUK AGRARIS MELALUI PENDIDIKAN KREATIF BERBASIS MASYARAKAT DI KELURAHAN DELINGAN, KARANGANYAR
Authors: Febriansyah Muhamad Iqbal , Mufadilah A’la , Tathma Fathia Rizka , Sirojd Milati Jaisyul’usrah , Safiera Refiana Nafis , Aprilia Riska Fenoria , Rahmandani Suci Wahyu , Nashir Muhammad , Setyono Prabang , Himawan Widhi , Nancy Natasha 
Published: November 2021

<p>Kapasitas teknis pengolahan lanjut hasil panen menjadi sekat bagi upaya peningkatan ekonomi dan kesejahteraan petani. Kondisi tersebut ditemukan pula pada masyarakat tani pada lokasi pengabdian di Kelurahan Delingan, Karanganyar. Hal tersebut bersumber dari rendahnya tingkat kepedulian dan partisipasi warga dalam pendidikan formal maupun non formal, termasuk pada pendidikan usia dini dan remaja. Tujuan kegiatan pengabdian ini adalah melaksanakan peningkatan kapasitas pengolahan pertanian dan perekonomian masyarakat melalui pendidikan berbasis masyarakat. Metode yang digunakan dalam kegiatan pengabdian adalah : pendidikan berbasis masyarakat, metode difusi ipteks, dan workshop. Hasil kegiatan pengabdian ini berupa pelaksanaan program kerja yang terdiri dari : pembuatan pupuk kompos, penanaman bibit tanaman, penanaman tanaman hias dengan jelly warna – warni (<em>hydrogel</em>), dan pengolahan nugget sayuran, serta 2 program penunjang (forum belajar dan BTQ). Kesimpulan dari seluruh kegiatan ini adalah bahwa kegiatan tersebut telah terlaksana dengan baik namun perlu dilakukannya pengawasan secara langsung oleh pemerintah setempat agar warga tetap konsisten dalam membangun Kelurahan Delingan. </p>
Management of Intracranial Pressure Control in Reciprocal Grade 3 Astrocytoma Patient In Dr. Moewardi General Hospital Surakarta: Case Report
Authors: Setijanto Eko , Wijaya Teddy 
Published: November 2021

<p><strong></strong>Surgery in patients with astrocytoma is performed based on the size of the tumor in the brain and the functional status of the patients. Management of patients with intracranial hypertension can be guided by monitoring intracranial pressure (ICP) perioperatively. A variety of ventricular, intraparenchymal, and subdural equipment can be installed by neurosurgeons to provide ICP measurements.</p><p>We reported a 50-year-old female patient, with a complaint of having a speech disorder since four years ago. Preoperative physical examination showed GCS E4V5M6, patient's body mass index was 29.29 kg/m<sup>2</sup> (obese). Patient’s physical status was assessed with ASA 3. There was no significant abnormality in laboratory examination. MRI Brain contrast examination showed solid cystic lesion in supratentorial left temporal lobe with size 2.3x3.5x4.7cm accompanied by broad perifocal edema in the left frontal, temporal and parietal lobe. The chest X-ray showed cardiomegaly and pneumonia. Electrocardiography showed normal sinus rhythm.</p><p>Craniotomy in patients with astrocytoma is performed based on the size of the tumor in the brain and the functional status of the patient. Preoperative evaluation for patients undergoing craniotomy should be carried out to determine the presence or absence of intracranial hypertension. In principle, postoperative management in the ICU is to control the respiratory system, optimize the cardiovascular system, and prevent possible complications.</p><p>Management of intracranial pressure control in reciprocal grade 3 astrocytoma patient should be paid attention to various things and consider the condition of the patients. Preoperative preparations, as well as perioperative and postoperative monitoring, should be carefully observed to prevent complications that will adversely affect patients.</p><p> </p>
Coronary Heart Disease: Diagnosis and Therapy
Authors: Mahmuda Iin Novita Nurhudayati , Nurkusumasari Nanda , Nofaldi Fakhri , Astuti Prihatin Puji , Syafitri Ferika Dian , Dessy Dessy 
Published: November 2021

<p>Coronary heart disease (CHD), is one of the non-communicable diseases that has a tendency to increase every year and have an impact not only on developed countries, but also in developing countries. According to the World Health Organization (WHO), in 2012 there were 56 million deaths worldwide caused by non-communicable disease and heart disease contributed 46.2% or caused 17.5 million deaths. This review article to give brief explanation about CHD from risk factors, diagnosed criteria, management therapy and prognosis. Risk factors for CHD can be distinguished into major risk factors and minor risk factors. Symptoms of CHD are discomfort in the chest ranging from pain crushed during activity and improved with rest to continuous chest pain. The diagnosis of CHD is established based on anamnesis, physical examination, and laboratory examination. The CHD classification consists of Stable Angina Pectoris (APS) and Acute Coronary Syndrome (ACS). Lifestyle changes accompanied<em> </em>by right medication can reduce complications caused by CHD.</p>
Pengaruh city branding dan electronic word of mouth terhadap kunjungan wisatawan di Kabupaten Banyuwangi
Authors: Muslim Shohib , Hidayati Nur , Pardiman Pardiman 
Published: November 2021

This study aims to examine the effect of city branding and electronic word of mouth on the decision to visit Banyuwangi based on the tagline sunrise of java. This research was conducted on the millennial generation in Indonesia. This type of research is explanatory research using a quantitative approach. The data used are primary data obtained based on the results of online questionnaire data from 160 respondents. Sampling using purposive sampling technique with the criteria of respondents having visited at least one tourist destination in Banyuwangi and actively using social media. The results showed that city branding and electronic word of mouth had a positive effect on the decision to visit. Electronic word of mouth has the most dominant influence on visiting decisions compared to city branding. Based on the results of the analysis show that this study provides a theoretical contribution to the factors that influence the decision to visit for tourists, namely city branding and electronic word of mouth. This research also makes a practical contribution in developing strategies to improve visiting decisions.
Pengungkapan Corporate Sosial Responsibility dan pemilihan audit independen
Authors: Lukman Loe Davina Clarissa , Eriandani Rizky 
Published: November 2021

This research was conducted to know the effect of voluntary corporate social responsibility on the request for independent audit selection with company characteristics as control and to know the influence of CSR disclosure on audit fees. This research uses quantitative methods. The population in the research is manufacturing industry sector companies located on the Indonesian Stock Exchange in the period 2017 to 2019. Samples in the study amounted to 435 manufacturing industry sectors that have met the criteria as research objects. The results obtained in this study show that CSR disclosure has a significant influence on independent audit selection. CSR does not have a significant influence on audit fees. The conclusion taken from the study is that CSR disclosure variables have a significant negative on the selection of audit independent with company characteristics as control.
Effect of Vugs on Hydraulic Fracture Propagation with Phase Field Method
Authors: Zeng Qingdong , Liu Wenzheng , Yao Jun 
Published: November 2021

Abstract
The interaction between hydraulic fracture and vugs affects the formed fracture pattern, which is of great significance for developing carbonate reservoirs efficiently. To investigate the effect of vugs on hydraulic fracture propagation, a hydromechanical coupling model is established based on the phase field method. Fluid flow in the porous media with vug is described by using phase field indicator functions. The pressure, displacement, and phase fields are solved by finite element approximation and iterative method, and the proposed model is validated against analytical solution. Some influencing factors including vug geometry and property are analyzed, and results show that the vug has important impact on hydraulic fracture propagation. The fracture diverts to the vug, and it could propagate across a small vug but be arrested by a large vug. As the distance between fracture and vug increases, the effect becomes weaker until it disappears. Besides, the modulus of vug fillings determines the fracture propagation pattern. The increase of vug filling modulus makes the fracture direct crossing difficult. The study could provide some guidance for hydraulic fracturing design of carbonate reservoirs.
Thermal Gradient Ring Reveals Thermosensory Changes in Diabetic Peripheral Neuropathy in Mice
Authors: Sasajima Sachiko , Kondo Masaki , Ujisawa Tomoyo , Motegi Mikio , Hayami Tomohide , Asano Saeko , Asano-Hayami Emi , Nakai-Shimoda Hiromi , Inoue Rieko , Yamada Yuichiro , Miura-Yura Emiri , Morishita Yoshiaki , Himeno Tatsuhito , Tsunekawa Shin , Kato Yoshiro , Nakamura Jiro , Kamiya Hideki , Tominaga Makoto 
Published: November 2021

Abstract
Diabetic peripheral neuropathy (DPN) includes symptoms of thermosensory impairment, which are reported to involve changes in the expression or function, or both, of nociceptive TRPV1 and TRPA1 channels in rodents. In the present study, we did not find changes in the expression or function of TRPV1 or TRPA1 in DPN mice, although thermal hypoalgesia was observed in a murine model of DPN or TRPV1–/– mice with a plantar test, which specifically detects temperature avoidance. With a Thermal Gradient Ring in which mice can move freely in a temperature gradient, temperature preference can be analyzed, and we clearly discriminated the temperature-dependent phenotype between DPN and TRPV1–/– mice. Accordingly, we propose approaches with multiple behavioral methods to analyze the progression of DPN by response to thermal stimuli. Attention to both thermal avoidance and preference may provide insight into the symptoms of DPN.
Hourly Analysis of Mechanical Ventilation Parameters in Critically Ill Adult Covid-19 Patients: Association with Mortality
Authors: Fariña-González Tomás F. , Núñez-Reiz Antonio , Latorre Julieta , Calle-Romero Maria , Yordanov-Zlatkov Viktor , Alonso-Martinez Patricia , Domingo-Marín Sara , Sánchez-García Miguel 
Published: November 2021

Abstract
Objective: there exists controversy about the pathophysiology and lung mechanics of COVID-19 associated ARDS, because some report severe hypoxemia with preserved respiratory system mechanics, contrasting with “classic” ARDS. We performed a detailed hourly analysis of the characteristics and time course of lung mechanics and biochemical analysis of patients requiring invasive mechanical ventilation for COVID-19-associated ARDS, comparing survivors and non-survivors.Methods and measurements: retrospective analysis of the data stored in the ICU information system of patients admitted in our hospital ICU that required invasive mechanical ventilation due to confirmed SARS-CoV-2 pneumonia between March 5th and April 30th, 2020. We compare respiratory system mechanics and gas exchange during the first ten days of IMV, discriminating volume and pressure controlled modes, between ICU survivors and non-survivors.Results: 140 patients were analyzed, analyzing 11,138 respiratory mechanics recordings. Global mortality was 38.6%. Multivariate analysis showed that age (OR 1,092, 95% (CI 1,014-1,176)), previous use of ACEI/ARBs (OR 4,612, (95% CI 1,19-17,84)) and need of renal replacement therapies (OR 10,15, (95% CI 1,58-65,11)) were associated with higher mortality. Respiratory variables start to diverge significantly between survivors and non-survivors after the 96 to 120 hours from mechanical ventilation initiation, particularly respiratory system compliance. In non survivors, mechanical power at 24 and 96 hs was higher regardless ventilatory mode. Conclusions: in patients admitted for SARS-CoV-2 pneumonia and requiring mechanical ventilation, non survivors have different respiratory system mechanics than survivors in the first 10 days of ICU admission. We propose a checkpoint at 96-120 hs to assess patients` improvement or worsening in order to consider escalating to extracorporeal therapies.“TAKE HOME MESSAGE”: assessing respiratory mechanics in the first 96-120 hs from ICU admission could predict the outcome of Covid-19 patients under mechanical ventilation.
No Evidence of SARS-CoV-2 Among Flies or Cockroaches in COVID-19 Positive Households
Authors: Roundy Christopher M , Hamer Sarah A. , Zecca Italo B. , Davila Edward B. , Auckland Lisa D. , Tang Wendy , Gavranovic Haley , Swiger Sonja L. , Tomberlin Jeffrey K. , Fischer Rebecca S. B. , Pauvolid-Corrêa Alex , Hamer Gabriel L. 
Published: November 2021

Abstract
Background:The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a pandemic of coronavirus disease (COVID-19), which continues to cause infections and mortality worldwide. SARS-CoV-2 is transmitted primarily via the respiratory route and has experimentally been found to be stable on surfaces for multiple days. Flies (Diptera) and other arthropods mechanically transmit several pathogens, including turkey coronavirus. A previous experimental study demonstrated house flies, Musca domestica, can mechanically transmit SARS-CoV-2, but the ability of flies in general to acquire and deposit this virus in natural settings has not been explored. The purpose of this study was to explore the possibility of mechanical transmission of SARS-CoV-2 by peridomestic insects and their potential as a xenosurveillance tool for detection of the virus.Methods:In order to optimize chances of viral detection, flies were trapped in homes where at least one confirmed human COVID-19 case(s) resided. Sticky and liquid baited fly traps were deployed inside and outside of the homes of SARS-CoV-2 human cases in Brazos, Bell, and Montgomery Counties, from June to September 2020. Flies from sticky traps were identified, pooled by taxa, homogenized, and tested for the presence of SARS-CoV-2 RNA using qRT-PCR. Liquid traps were drained, and the collected fluid similarly tested after RNA concentration. Experimental viral detection pipeline and viral inactivation were confirmed in a Biosafety Level 3 lab. As part of a separate ongoing study, companion animals in the home were sampled and tested for SARS-CoV-2 on the same day of insect trap deployment.Results:We processed the contents of 133 insect traps from 44 homes, which contained over 1,345 individual insects of 11 different Diptera families and Blattodea.These individuals were grouped into 243 pools, and all tested negative for SARS-CoV-2 RNA. Dead flies exposed to SARS-CoV-2 in a BSL3 lab were processed using the same methods and viral RNA was detected by RT-PCR. Fourteen traps in seven homes were deployed on the day that cat or dog samples tested positive for SARS-CoV-2 RNA by nasal, oral, body, or rectal samples.Conclusions:This study presents evidence that biting and non-biting flies are not likely to contribute to mechanical transmission of SARS-CoV-2 or be useful in xenosurveillance for SARS-CoV-2.
Non-linear association between daily dietary folate intake and cognitive performance in elder America: A population-based cross-sectional study
Authors: Wu Xiaohua , Wang Chaoqun , Wang Yan , Yuan Lingmei , Deng Li , Gao Lijie 
Published: November 2021

Abstract
Background
The association between daily dietary folate intake and cognitive performance in older populations is unclear.
Methods
This study aimed to investigate whether a dose-dependent association exists between dietary folate levels and cognition performance. The 2011–2014 datasets from the National Health and Nutrition Examination Survey were collected. Data from adults aged ≥ 60 years who completed all three cognitive tests with daily dietary data were analyzed. Weighted smooth curve fitting and multiple linear regression models were applied to study the association between folate intake and cognitive performance. Age, sex, race, education, smoking status, alcohol intake, body mass index, hypertension, stroke, diabetes, and depression were adjusted using a weighted multiple regression model.
Results
Data from 1,255 participants were analyzed. The mean age of the study population was 69.3 years. Males accounted for a weighted 48.8% of the total population. Daily dietary folate was not significantly associated with delayed recall (per 10 mcg/day increment, β 0.003, 95% CI -0.002–0.009, P = 0.23). Below the cut-off of 250 mcg/day, dietary folate intake was positively associated with immediate recall (per 10 mcg/day increment, β 0.01, 95% CI 0.00–0.02, P = 0.05) and animal fluency test score (per 10 mcg/day increment, β 0.02, 95% CI 0.00–0.03, P = 0.05). However, above this cut-off, the association was not significant. Dietary folate intake was not significantly associated with an increase in the digit symbol substitution test score until dietary the folate intake reached 250 mcg/d (per 10mcg/d increment, β 0.29, 95% CI 0.05-0.53, P = 0.04).
Conclusion
Daily dietary folate intake was non-linearly associated with cognitive performance in the older American population.
Therapeutic Drug Monitoring of Voriconazole in AIDS Patients
Authors: Chen Tingting , Lin Zhiqiang , Zhang Huatang , Zhang Qingquan , Hong Limian , Wu Shuifa 
Published: November 2021

Abstract
Background

The safety and efficacy of Voriconazole in Acquired Immune Deficiency Syndrome (AIDS) patients is difficult to guarantee. In this study, Therapeutic Drug Monitoring (TDM) of Voriconazole in AIDS patients was investigated with the aim to further verify the significance of voriconazole TDM in AIDS patients and to explore more strategies to improve individualized medication.
Methods

The data of AIDS patients who underwent voriconazole TDM in our hospital from May 2018 to August 2021 were collected. The basic information of patients, the results of voriconazole TDM, the individualized intervention, the affecting factors of voriconazole concentration were analyzed, as well as the relationship between voriconazole trough concentration and safety.
Results

A total of 46 tests of voriconazole TDM were performed in 28 AIDS patients. Only 57.14% patients reached the therapeutic range at first TDM, and 87.50% patients reached the therapeutic range after intervention based on first TDM. 21.43% patients develop voriconazole-related Adverse Drug Reactions (ADRs), and ADRs were mostly occurred when voriconazole concentration is above 5.0 µg/mL. Spearman correlation coefficient rs was calculated to be 0.729 for voriconazole trough concentration and the incidence of ADRs, exhibiting a significant, positive linear correlation (P=0. 017). 50% patients had polypharmacy and drug interactions are common. For example, rifampicin can significantly reduce the plasma concentration of voriconazole. Multiple linear regression analysis showed Hypoproteinemia was a significant factor affecting voriconazole trough concentration(P=0.006).
Conclusion

AIDS patients usually have a low attainment rate of voriconazole trough concentration after initiation of standard dosing regimen. The affecting factors seem multifactorial and complex, of which hypoproteinemia is of great significance. Meanwhile, we need to be alert to the effects of drug interactions. The incidence of voriconazole related ADRs is high, mostly occurring when voriconazole concentration is above 5.0 µg/mL. Therefore, TDM can provide meaningful guidance for dosage optimization of voriconazole, and the dosage adjustment method in Chinese Guideline is applicable for the population of AIDS patients.