bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal-Epithelial Transition Exon 14 Skipping Mutation and Amplification in 5,008 Patients With Lung Cancer
Authors: Song Yaolin , Li Guangqi , Ju Kun , Ran Wenwen , Zhao Han , Liu Xianglan , Hou Mingyu , He Yulu , Chen Yang , Zang Guoliang , Xing Xiaoming 
Published: September 2021

BackgroundLung cancer is a major health concern worldwide because of its increasing incidence and mortality. This study aimed to clarify the association between mesenchymal-epithelial transition (MET) genomic alterations and clinical characteristics of lung cancer.MethodWe collected data from 5,008 patients with lung cancer diagnosed and treated between January 2017 and July 2021 at the Affiliated Hospital of Qingdao University. Genomic alterations in the MET gene, including the exon 14 skipping mutation and amplification, were detected using amplification refractory mutation system-polymerase chain reaction (2,057 cases) and next-generation sequencing (2,951 cases). Clinical characteristics such as age, sex, tumor location, tumor stage, smoking, pleural invasion, and histology were statistically analyzed for MET exon 14 skipping mutation and amplification. The DNA splicing sites causing the MET exon 14 skipping mutation at the mRNA level were also investigated.ResultsThe incidence of the MET exon 14 skipping mutation was 0.90% (41/4,564) in adenocarcinoma, 1.02% (3/294) in squamous cell carcinoma, and 8.33% (1/12) in sarcomatoid carcinoma specimens. It was more frequently observed in patients over 60 years of age than the MET exon 14 skipping mutation wildtype. The MET exon 14 skipping mutation co-occurred with epidermal growth factor receptor (EGFR) L858R, EGFR 19-Del, and BRAF V600E mutations. At the DNA level, single nucleotide mutation and small fragment deletion (1–38 base pairs) upstream and downstream of MET exon 14 led to MET exon 14 skipping mutation at the mRNA level. MET amplification occurred in 0.78% (21/2,676) adenocarcinoma and 1.07% (2/187) squamous cell carcinoma specimens and was significantly associated with advanced tumor stages (III + IV) compared to the MET amplification wildtype. MET amplification primarily co-occurred with the EGFR mutation.ConclusionsOur study found that MET genomic alterations were statistically related to age and tumor stage and co-existed with mutations of other oncogenic driver genes, such as EGFR and BRAF. Moreover, various splicing site changes at the DNA level led to the exon 14 skipping mutation at the mRNA level. Further studies are required to clarify the association between MET genomic alterations and prognosis.
Optical Frequency Down-Conversion With Bandwidth Compression Based on Counter-Propagating Phase Matching
Authors: Guo Dong-Jie , Yang Ran , Liu Yi-Chen , Duan Jia-Chen , Xie Zhenda , Gong Yan-Xiao , Zhu Shi-Ning 
Published: September 2021

Optical quantum network plays an important role in large scale quantum communication. However, different components for photon generation, transmission, storage and manipulation in network usually cannot interact directly due to the wavelength and bandwidth differences, and thus interfaces are needed to overcome such problems. We propose an optical interface for frequency down-conversion and bandwidth compression based on the counter-propagating quasi-phase-matching difference frequency generation process in the periodically-poled lithium niobate on insulator waveguide. We prove that a separable spectral transfer function can be obtained only by choosing proper pump bandwidth, thus relaxing the limitation of material, dispersion, and working wavelength as a result of the counter-propagation phase-matching configuration. With numerical simulations, we show that our design results in a nearly separable transfer function with the Schmidt number very close to 1. With proper pump bandwidth, an photon at central wavelength of 550 nm with a bandwidth ranging from 50 GHz to 5 THz can be converted to a photon at central wavelength of 1,545 nm with a much narrower bandwidth of 33 GHz.
Wondering Awe as a Perceptive Aspect of Spirituality and Its Relation to Indicators of Wellbeing: Frequency of Perception and Underlying Triggers
Authors: Büssing Arndt 
Published: September 2021

Background: Spirituality is a multidimensional construct which includes religious, existentialistic, and relational issues and has different layers such as faith as the core, related attitudes and conviction, and subsequent behaviors and practices. The perceptive aspects of spirituality such as wondering awe are of relevance for both, religious and non-religious persons. These perceptions were related to perceiving the Sacred in life, mindful awareness of nature, others and self, to compassion, meaning in life, and emotional wellbeing. As awe perceptions are foremost a matter of state, it was the aim (1) to empirically analyze the frequency of wondering awe perceptions (i.e., with respect to gender, age cohorts, religious or non-religious persons) and (2) to qualitatively analyze a range of triggers of awe perceptions.Methods: Data from 7,928 participants were analyzed with respect to the frequency of Awe/Gratitude perceptions (GrAw-7 scale), while for the second part of the study responses of a heterogeneous group of 82 persons what caused them to perceive moments of wondering awe were analyzed with qualitative content analysis techniques.Results: Persons who experience Awe/Gratitude to a low extend were the youngest and had lowest wellbeing and lowest meditation/praying engagement, while those with high GrAw-7 scores were the oldest, had the highest wellbeing, and were more often meditating or praying (p&lt;0.001). Gender had a significant effect on these perceptions, too (Cohen’s d=0.32). In the qualitative part, the triggers can be attributed to four main categories, Nature, Persons, Unique Moments, and Aesthetics, Beauty, and Devotion. Some of these triggers and related perceptions might be more a matter of admiration than wondering awe, while other perceptions could have more profound effects and may thus result in changes of a person’s attitudes and behaviors.Conclusion: Emotionally touching experiences of wondering awe may result in feelings of interconnectedness, prosocial behavior, mindful awareness, and contribute to a person’s meaning in life and wellbeing and can also be a health-relevant resource. These perceptions can be seen as a perceptive aspect of spirituality, which is not exclusively experienced by religious people but also by non-religious persons.
Improving Antioxidant Capacity in Children With Autism: A Randomized, Double-Blind Controlled Study With Cysteine-Rich Whey Protein
Authors: Castejon Ana Maria , Spaw Jordan Ashley , Rozenfeld Irina , Sheinberg Nurit , Kabot Susan , Shaw Alexander , Hardigan Patrick , Faillace Rogerio , Packer Edward E. 
Published: September 2021

Previous studies indicate that children with autism spectrum disorder (ASD) have lower levels of glutathione. Nutritional interventions aim to increase glutathione levels suggest a positive effect on ASD behaviors, but findings are mixed or non-significant. A commercially available nutritional supplement comprising a cysteine-rich whey protein isolate (CRWP), a potent precursor of glutathione, was previously found to be safe and effective at raising glutathione in several conditions associated with low antioxidant capacity. Therefore, we investigated the effectiveness of a 90-day CRWP intervention in children with ASD and examined whether intracellular reduced and oxidized glutathione improvements correlated with behavioral changes. We enrolled 46 (of 81 screened) 3–5-year-old preschool children with confirmed ASD. Using a double-blind, randomized, placebo-controlled design, we evaluated the effectiveness of daily CRWP (powder form: 0.5 g/kg for children &lt;20 kg or a 10-g dose for those &gt;20 kg), compared with placebo (rice protein mimicking the protein load in the intervention group), on glutathione levels and ASD behaviors assessed using different behavioral scales such as Childhood Autism Rated Scale, Preschool Language Scale, Social Communication Questionnaire, Childhood Behavioral Checklist and the parent-rated Vineland Adaptive Behavior Scale, 2nd edition (VABS-II). Forty children (CRWP, 21; placebo, 19) completed the 90-day treatment period. Improvements observed in some behavioral scales were comparable. However, the VABS-II behavioral assessment, demonstrated significant changes only in children receiving CRWP compared to those observed in the placebo group in the composite score (effect size 0.98; 95% confidence intervals 1.42–4.02;p= 0.03). Further, several VABS-II domain scores such as adaptive behavior (p= 0.03), socialization (p= 0.03), maladaptive behavior (p= 0.04) and internalizing behavior (p= 0.02) also indicated significant changes. Children assigned to the CRWP group showed significant increases in glutathione levels (p= 0.04) compared to those in the placebo group. A subanalysis of the VABS-II scale results comparing responders (&gt;1 SD change from baseline to follow up) and non-responders in the CRWP group identified older age and higher levels of total and reduced glutathione as factors associated with a response. CRWP nutritional intervention in children with ASD significantly improved both glutathione levels and some behaviors associated with ASD. Further studies are needed to confirm these results.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/study/NCT01366859, identifier: NCT01366859.
Risk of PTSD Due to the COVID-19 Pandemic Among Patients in Opioid Substitution Treatment
Authors: Fuchs-Leitner Isabella , Yazdi Kurosch , Gerstgrasser Nikolas W. , Tholen Matthias G. , Graffius Sophie-Therés , Schorb Alexander , Rosenleitner Jan 
Published: September 2021

Background: The impact of the COVID-19 pandemic on the mental health of patients suffering from addictive disorders is of major concern. This study aimed to explore the presence and potential increase in post-traumatic stress disorder (PTSD) symptoms, depression, and anxiety since the beginning of the pandemic for patients in opioid substitution therapy (OST).Methods: This cross-sectional survey study evaluated a clinical sample of patients in OST (N = 123). Symptoms of post-traumatic stress disorder (PTSD) due to the COVID-19 pandemic were assessed by an adapted version of the impact of event scale (IES-R), resulting in two subgroups of low and high risk for PTSD. The depression, anxiety, and stress scale (DASS-21) was applied to collect data on the respective symptoms, and changes since the onset of the pandemic were reported on separate scales. Sociodemographic and COVID-19 related factors, as well as data on craving, consumption patterns, concomitant use, and the drug market were further assessed.Results: A binary logistic regression analysis confirmed the impact of self-perceived higher burden by psychological and economic factors on the elevated risk for PTSD due to the pandemic. The high-risk PTSD group also showed higher levels of depression, anxiety and stress, as well as a more pronounced deterioration in these symptoms since the pandemic. While reported levels of craving did not differ between the two groups, the high-risk PTSD group indicated a significantly higher increase in craving since the crisis, when compared to the low-risk group.Discussion: Our findings demonstrate elevated levels of clinical symptoms among patients in OST, with more than a quarter of patients found at risk for PTSD due to the COVID-19 pandemic. Furthermore, about 30–50% of our patients reported concerning levels of depression, anxiety, or stress. Special attention should be drawn to these findings, and potential deterioration of the situation should be addressed by health care facilities. Particularly, psychological, and financial burden due to the crisis were identified as factors increasing the risk for PTSD. These factors can easily be evaluated during routine anamneses, and might be a valuable source of information, when special attention is needed.
Network Analysis of Depressive Symptoms Among Residents of Wuhan in the Later Stage of the COVID-19 Pandemic
Authors: Zhao Na , Li Wen , Zhang Shu-Fang , Yang Bing Xiang , Sha Sha , Cheung Teris , Jackson Todd , Zang Yu-Feng , Xiang Yu-Tao 
Published: September 2021

Background: Depression has been a common mental health problem during the COVID-19 epidemic. From a network perspective, depression can be conceptualized as the result of mutual interactions among individual symptoms, an approach that may elucidate the structure and mechanisms underlying this disorder. This study aimed to examine the structure of depression among residents in Wuhan, the epicenter of the COVID-19 outbreak in China, in the later stage of the COVID-19 pandemic.Methods: A total of 2,515 participants were recruited from the community via snowball sampling. The Patient Health Questionnaire was used to assess self-reported depressive symptoms with the QuestionnaireStar program. The network structure and relevant centrality indices of depression were examined in this sample.Results: Network analysis revealed Fatigue, Sad mood, Guilt and Motor disturbances as the most central symptoms, while Suicide and Sleep problems had the lowest centrality. No significant differences were found between women and men regarding network structure (maximum difference = 0.11, p = 0.44) and global strength (global strength difference = 0.04; female vs. male: 3.78 vs. 3.83, p = 0.51), a finding that suggests there are no gender differences in the structure or centrality of depressive symptoms.Limitations: Due to the cross-sectional study design, causal relationships between these depressive symptoms or dynamic changes in networks over time could not be established.Conclusions: Fatigue, Sad mood, Guilt, and Motor disturbances should be prioritized as targets in interventions and prevention efforts to reduce depression among residents in Wuhan, in the later stage of the COVID-19 pandemic.
The Psychological Effect of Internet-Based Mindfulness-Based Stress Reduction on the Survivors of Breast Cancer During the COVID-19
Authors: Kang Chuanyuan , Sun Shufang , Yang Zhuangqing , Fan Xinxin , Yuan Jing , Xu Li , Wei Yujun , Tong Huiqi , Yang Jianzhong 
Published: September 2021

Objective: To examine the efficacy and the role of engagement of an internet-based Mindfulness-based Stress Reduction (iMBSR) for survivors of breast cancer (BC) during the COVID-19 period from January to March in 2020 in China.Methods: 48 survivors of BC were divided into the absentees group and the iMBSR groups according to their attending to the standardized, group-based, 8-week iMBSR. Based on practice time, survivors of BC in the iMBSR were categorized into three subgroups: group 1 (&lt;30 min/day), group 2 (30–60 min/day), and group 3 (&gt;60 min/day). In addition, participants were classified as partial attendees (&lt;4 sessions) and completers (more than 4 sessions) of the iMBSR groups. All participants were evaluated for symptoms of depression, anxiety and insomnia at baseline, mid-intervention, and post-intervention.Results: After an 8-week iMBSR practice, at mid-intervention and post-intervention, participants in iMBSR group had significant improvement in scores and reduction rates of depression, anxiety, and insomnia compared to absentees. Scores of depression and insomnia, reduction rates of depression at post-intervention, scores of anxiety, reduction rates of anxiety and insomnia at mid-intervention and post-intervention, had significant differences among subgroups of practice time. Daily practice time was positively related to reduction rates of depression, anxiety and insomnia at post-intervention in the iMBSR group.Conclusion: Internet-based MBSR showed efficacy in reducing psychological symptoms among survivors of BC. For survivors of BC, iMBSR practice has a potential dose–response efficacy, with a threshold of &gt;30 min daily practice for most optimal symptoms reduction.Trial Registration: Registration number is [ChiCTR2100044309].
Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma
Authors: Wang Qiang , Ji Yujun , Brismar Torkel B. , Chen Shu , Li Changfeng , Jiang Jiayun , Mu Wei , Zhang Leida , Sparrelid Ernesto , Ma Kuansheng 
Published: September 2021

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) stage-1 in treatment of cirrhosis-related hepatocellular carcinoma (HCC).Methods: For HCC patients with insufficient FLR, right-sided PVE was first performed, followed by percutaneous RFA to the tumor as a means to trigger FLR growth. When the FLR reached a safe level (at least 40%) and the blood biochemistry tests were in good condition, the hepatectomy was performed. FLR dynamic changes and serum biochemical tests were evaluated. Postoperative complications, mortality, intraoperative data and long-term oncological outcome were also recorded.Results: Seven patients underwent PVE+RFA for FLR growth between March 2016 and December 2019. The median baseline of FLR was 353 ml (28%), which increased to 539 (44%) ml after 8 (7–18) days of this strategy (p &lt; 0.05). The increase of FLR ranged from 40% to 140% (median 47%). Five patients completed hepatectomy. The median interval between PVE+RFA and hepatectomy was 19 (15–27) days. No major morbidity ≥ III of Clavien-Dindo classification or in-hospital mortality occurred. One patient who did not proceed to surgery died within 90 days after discharge. After a median follow-up of 18 (range 3–50) months, five patients were alive.Conclusion: Sequential PVE+RFA is a feasible and effective strategy for FLR growth prior to extended hepatectomy and may provide a minimally invasive alternative for ALPPS stage-1 for treatment of patients with cirrhosis-related HCC.
Effects of Ibuprofen Use on Lymphocyte Count and Oxidative Stress in Elite Paralympic Powerlifting
Authors: Aidar Felipe J. , Fraga Guacira S. , Getirana-Mota Márcio , Marçal Anderson Carlos , Santos Jymmys L. , de Souza Raphael Fabricio , Ferreira Alexandre Reis Pires , Neves Eduardo Borba , Zanona Aristela de Freitas , Bulhões-Correia Alexandre , de Almeida-Neto Paulo Francisco , Fernandes Tulio Luiz Banja , Garrido Nuno Domingos , Cirilo-Sousa Maria do Socorro , Merino-Fernández María , Díaz-de-Durana Alfonso López , Murawska-Ciałowicz Eugenia , Cabral Breno Guilherme de Araújo Tinoco , Clemente Filipe Manuel 
Published: September 2021

Background: Paralympic Powerlifting (PP) training tends to promote fatigue and oxidative stress. Objective: To analyze the effects of ibuprofen use on performance and oxidative stress in post-training PP athletes. Methodology: Ten national level PP athletes (age: 27.13 ± 5.57) were analyzed for oxidative stress in post-training. The study was carried out in three weeks, (1) familiarization and (2 and 3) evaluated the recovery with the use of a placebo (PLA) and ibuprofen (IBU), 800 mg. The Peak Torque (PT), Torque Development Rate (TDR), Fatigue Index (FI), reactive substances to thiobarbituric acid (TBARS) and sulfhydryl groups (SH) were evaluated. The training consisted of five sets of five repetitions (80–90%) 1-Repetition Maximum (1-RM) in the bench press. Results: The IBU showed a higher PT (24 and 48 h, p = 0.04, ɳ2 p = 0.39), a lower FI (24 h, p = 0.01, ɳ2p = 0.74) and an increased lymphocyte count (p < 0.001; ɳ2p = 4.36). There was no change in oxidative stress. Conclusions: The use of IBU provided improvements in strength and did not protect against oxidative stress.
Analisis Cluster dengan Metode Partitioning dan Hierarki pada Data Informasi Kemiskinan Provinsi di Indonesia Tahun 2019
Authors: Afira Natasya , Wijayanto Arie Wahyu 
Published: September 2021

Kemiskinan merupakan salah satu indikator penting dalam melihat keberhasilan pembangunan ekonomi suatu negara. Tingkat kemiskinan di Indonesia sebesar 9,22 persen dengan jumlah penduduk miskin sebanyak 24,79 juta jiwa. Data kemiskinan di setiap daerah akan berbeda dipengaruhi oleh berbagai indikator. Oleh karena itu penting untuk mengelompokkan daerah-daerah di Indonesia berdasarkan karakteristik kemiskinan sehingga pemerintah dapat dengan tepat mengambil kebijakan terkait penanggulangan kemiskinan. Penelitian ini menggunakan dua metode clustering, yaitu partitioning dan hierarki untuk mengelompokkan provinsi-provinsi di Indonesia berdasarkan karakteristik kemiskinan. Metode partitioning yang dipilih adalah K-Means. Data yang digunakan adalah 8 variabel kemiskinan pada 34 provinsi di Indonesia tahun 2019. Penentuan jumlah cluster menggunakan validasi internal dan validasi stabilitias menunjukkan bahwa metode hierarki dengan jumlah cluster 2 menghasilkan cluster yang paling optimal. Perbandingan metode hierarki dinilai berdasarkan agglomerative coefficient, dimana metode Ward mampu memberikan hasil pengelompokan terbaik.
Religiões Afrodiaspóricas na América Latina
Authors: Giraldo Hortegas Monica 
Published: September 2021

Religiões afrodiaspóricas na América Latina existem a partir de um contexto histórico que nasce na África e chega até este continente sob o cerceamento de uma estrutura colonial que ainda é possível perceber na atualidade. Autores decoloniais têm refletido sobre as epistemologias de poder e seus efeitos nefastos. A partir do estudo destas religiões, é possível compreender parâmetros não apenas do universo religioso, mas sociais, culturais e morais nos quais estamos, enquanto sociedade, submetidos. Para autores decoloniais, como Aníbal Quijano, que serão aqui abordados, é possível pensar em uma nova forma de habitar. Para isso, é preciso uma desconstrução deste pensamento que pensamos como natural. A religião aqui apresenta-se como um caminho para um novo mundo, mais justo e compassivo.
Palavras-chave: religiões afrodiaspóricas; América Latina; decolonialidade
PESQUISAR: UM EMARANHADO NO ENTRE DA FORMAÇÃO DE PROFESSORES E PROFESSORAS, PRODUÇÃO MATEMÁTICA E POLÍTICAS COGNITIVAS
Authors: Sacramento Rotondo Margareth Ap. 
Published: September 2021

Esse artigo apresenta uma trama da produção do pesquisar em educação e do processo de formação de uma pesquisadora. Os fios dessa trama – formação de professores e professoras, políticas cognitivas e produção matemática – apresentam-se junto à vivência na educação escolar de uma professora, lugar que dá passagem aos afetos do educar e do educar matematicamente, tornam-na, então, professora-pesquisadora. A trama apresenta encontro com problemas, compondo-se como aquilo que causa desassossego às faculdades, possibilitando o nascer do pensar no pensamento e fazendo emergir modos de pesquisar e a produção de um pesquisar e de uma pesquisadora. A perturbação com os processos formativos e como se dá o pensar no pensamento alimentam o pesquisar, desde as salas de aulas do ensino fundamental até os processos formativos de professoras e professores, compreendendo intensa implicação entre pensar e existir.

Palavras-chave: processos formativos; produção do conhecimento; pesquisar.
ENCONTROS NA OFICINA DE UMA HISTORIADORA
Authors: Maia de Souza Maria Zélia 
Published: September 2021

O objetivo do presente trabalho é refletir sobre o modo pelo qual uma professora/pesquisadora, das questões que dizem respeito à história da educação pública brasileira e norte americana do século XIX, exerce o seu ofício. Divido-o em três momentos: no primeiro narro o meu encontro com Maria Firmina e a aproximo da construção de minha vida profissional, ou seja, um encontro com outra Maria. Em seguida apresento as escolhas dos objetos de pesquisa para em seguida narrar os meus encontros com os teóricos aos quais estabeleci interlocução. Por fim, as indagações sobre o oficio de historiadora da educação, as questões sobre o sentido da escola de hoje e de outros tempos, a intuição de que trajetórias individuais sempre oferecem a possibilidade de relacionar história e vidas (MIGNON, 2010) foram pouco a pouco preparando o caminho para o meu encontro com você, leitor e leitora.