bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy and Safety of Postoperative Tranexamic Acid, Hemocoagulase Agkistrodon, and their Combination in Patients Undergoing Heart Valve Replacement With Cardiopulmonary Bypass
Authors: Chen Jingxiu , Li Jingjie , Yan Jiajia , He Qiuyi , Huang Min , Chen Xiao , Chen Pan 
Published: November 2021

Abstract
Background

Excessive bleeding is a major complication in patients undergoing cardiac surgery. We aimed to compare the efficacy and safety of postoperative tranexamic acid (TXA), hemocoagulase agkistrodon and their combination in patients undergoing heart valve replacement surgery with cardiopulmonary bypass (CPB).
Methods

This was a retrospective study. The enrolled patients were intravenously injected with TXA at a dose of 1.0 g during the intraoperative period. After surgery, the patients were assigned to four groups: the control group (Group C), the TXA group (Group T), the hemocoagulase agkistrodon group (Group H) and the combination group (Group TH). The primary efficacy outcomes were the total blood loss (TBL) from the time of the operation to postoperative Day 2, postoperative blood loss within 2 days, and transfusion of red blood cells and plasma from the operation to postoperative Day 3. The primary safety endpoint was the incidence of thromboembolic events.
Results

A total of 252 patients were recruited. There were no statistically significant differences in terms of the TBL, postoperative blood loss, volumes of red blood cells or plasma transfusion among the four groups. However, an increased total pericardial drainage volume and longer length of stay in the ICU were found in Group H compared with in Group T. In addition, increased volumes of total pericardial drainage were found in Group TH compared with Groups C and T. A similar result was also found in the number of days of pericardial drainage. Regarding safety outcomes, fibrinogen levels on postoperative Days 1 and 2 in Groups H and TH were significantly lower than those in Groups C and T, while the frequencies of human fibrinogen transfusion in Groups H and TH were higher, with the highest frequency in Group H. The transfusions of human fibrinogen among Groups C, T, H and TH were 1.45%, 2.78%, 64.71%, and 28.72%, respectively. No significant differences were found in the postoperative incidences of thromboembolic events and acute kidney injuries among all groups.
Conclusions

Bleeding events after cardiac valve replacement surgery with CPB were not improved by postoperative administration of TXA, hemocoagulase agkistrodon or their combination. Hemocoagulase agkistrodon is related to hypofibrinogenemia and increased transfusions of human fibrinogen.
A New Method of Identifying Key Industries: A Principal Component Analysis
Authors: Tsoulfidis Lefteris , Athanasiadis Ioannis 
Published: November 2021

Abstract
This article using the principal components analysis identifies key industries and groups them into particular clusters. The data come from the US benchmark input-output tables of the years 2002, 2007, 2012 and the most recently published input-output table of the year 2019. We observe some intertemporal switches of industries both between and within the top clusters. The findings further suggest that structural change is a slow moving process and it takes time for some industries to move from one cluster to the other. This information may be proved important in the designation of effective economic policies by targeting particular industries and also for the stability properties of the economic system.JEL classifications: B24, B51, C67, D46, D57, E11, E32
Assessing the Determinants of Electricity Generation Infrastructure in Nigeria
Authors: Olanrele Iyabo 
Published: November 2021

Abstract
The supply and demand for electricity have outpaced available infrastructure in Nigeria despite the abundant energy resources. The paper investigates the determinants of electricity generating infrastructure in Nigeria for the period 1980 to 2016. Using an Autoregressive Distributed Lag model, electricity generation capacity was used as an indicator for electricity infrastructure development. Its expansion was based on the behaviour of inflation rate, total government expenditure, interest rate, private sector financial credit, exchange rate, real GDP per capita, real gross fixed capital formation, and the rate of urbanisation. Financial credit to private sector, total public expenditure, real per capita income, real gross fixed capital formation, urbanization, and exchange rate adversely affect the development of electricity generation capacity. Investment in generating assets is capital intensive, which should be matched with adequate private sector financing. If the power sector subsidy will remain and achieve its objective, strategies that will lead to sustaining exchange rate stability should be promoted. Based on estimate, every one million population require 1000MW of electricity to function in modern-day society implying that Nigeria needs 180,000MW of electricity capacity. The realisation of this is hinged on large scale electricity infrastructure investment enabled, partly, by the favourable macroeconomic environment.JEL Classification: E16, O1, O2
Novel Mutation of SIK1 Gene Causing a Mild Form of Pediatric Epilepsy in a Chinese Family
Authors: Xu Wangshu , Zhang Wenqun , Cui Lili , Shi Lei , Zhu Bin , lv Tianjie , Ma Wenping 
Published: November 2021

Abstract
Objective: Early infantile epileptic encephalopathy (EIEE) is a group of disorders affecting children at early stages of infancy, which is characterized by frequent seizures, epileptiform activity on EEG, and developmental retardation or regression. Salt-inducible kinases (SIKs) syndrome is a newly described EIEE, caused by heterozygous mutations in the salt-inducible kinase SIK1, which can present as early myoclonic encephalopathy, Ohtahara syndrome, and infantile spasms. Methods: In this study, we investigated a patient with early onset epilepsy. DNA sequencing of the whole coding region revealed a de novel heterozygous nucleotide substitution (c.880G>A) causing a missense mutation (p.A294T). This mutation was classified as variant of unknown significance (VUS) by American College of Medical Genetics and Genomics (ACMG). To further investigate the pathogenicity and pathogenesis of this mutation, we established a human neuroblastoma cell line (SH-SY5Y) stably-expressing wild type SIK1 and A294T mutant, and compared the transcriptome and metabolomics profiles. Results: We presented a pediatric patient suffering from infantile onset epilepsy. Early EEG showed a boundary dysfunction of activity and MRI scan of the brain was normal. The patient responded well to single anti-epileptic drug treatment. Whole-exome sequencing found a missense mutation of SIK1 gene (c.880G>A chr21: 43420326 p. A294T). Dysregulated transcriptome and metabolome in cell models expressing WT and MUT SIK1 confirmed the pathogenicity of the mutation. Specifically, we found MEF2C target genes, certain epilepsy causing genes and metabolites are dysregulated by SIK1 mutation.We found MEF2C target genes, certain epilepsy causing genes and metabolites are dysregulated by SIK1 mutation. Significance: Our finding further expanded the disease spectrum and provided novel mechanistic insights of SIK1 syndrome.
Consumption of Coconut Oil Affects adipose miRNA Profile in Pigs.
Authors: Oczkowicz Maria , Pawlina-Tyszko Klaudia , Świątkiewicz Małgorzata , Szmatoła Tomasz 
Published: November 2021

Abstract
Circulating miRNA molecules are intensively studied for their usefulness as biomarkers of civilization diseases. At the same time, it is known that diet can influence the level of miRNA expression in tissues. Our research aimed to determine how a diet containing various sources of fat (rapeseed oil, beef tallow, coconut oil) and different amounts of cDDGS (corn Dried Distilled Grains with Solubles) affects the miRNA profile in pig fat – the main source of circulating miRNAs. For this purpose, we used Next Generation Sequencing of miRNA libraries. We observed the highest number of differentially expressed miRNAs in the samples from animals that were fed with coconut oil in the diet compared to all other treatments. In contrary, cDDGS appeared to have little effect on miRNA expression. We propose a subset of di-et-related, adipose-specific, conservative miRNAs among mammals, namely: ssc-miR-99b, ssc-miR-4334-3p, ssc-miR-146b, ssc-miR-23a. Moreover, we observed that several miRNAs regulated by dietary fats are considered as biomarkers in human and animal diseases.
Incidence and Effects of Posterior Cranial Vault Deformation in Adult Females With Skeletal Class III Malocclusion
Authors: Fujimoto Kouta , Sasaki Au , Kawajiri Akemi , Yamaguchi Koji , Oshima Takafumi , Togane Yuri , Otsuka Yuichiro , Suda Naoto 
Published: November 2021

Abstract
BackgroundThe precise characteristics of posterior cranial vault deformation are difficult to identify using a two-dimensional analysis. Recently, three-dimensional analysis using computed tomography (CT) data and software analysis has enabled us to examine the craniofacial structure precisely. To identify the deformation in the cranial vaults by a three-dimensional analysis and examine its effects on other structures, CT data of skeletal mandibular protrusion cases without lateral deviation of pogonion (Pog) were examined.MethodsThirty-two adult female patients with skeletal mandibular protrusion who visited Meikai University Hospital were included in this study. CT images were taken before orthognathic surgeries, and the craniofacial structures were examined threedimensionally.The lateral deviation of Pog was less than 3 mm in all cases.Genetic/congenital anomaly cases, endocrine disorders, or cases with severe trauma or temporomandibular disorder were excluded.ResultsMany cases had three-dimensional deformations in the cranial vaults. The cranial vaults with unilateral posterior deformation had posteriorly positioned mandibular fossae on the same sides. Mandibular body lengths were related to the position of the mandibular fossae, and the posterior mandibular fossae tended to have longer mandibular body lengths on the same sides. Masseter muscles with larger volumes were related to longer mandibular body lengths.Conclusions﻿Mandibular body lengths can compensate for the bilateral difference in the position of the mandibular fossae to avoid lateral deviation of the Pog. The masseter muscles are likely one of the factors related to the bilateral differences in the mandibular body length.
Inkoo And Sindbis Viruses In Semi-Domesticated Reindeer And Mosquitoes In Norway
Authors: Shakya Ruchika , Tryland Morten , Vikse Rose , Romano Javier Sánchez , Åsbakk Kjetil , Nymo Ingebjørg H. , Mehl Reidar , Evander Magnus , Ahlm Clas , Vapalahti Olli , Lwande Olivia Wesula , Putkuri Niina , Johansen Wenche , Soleng Arnulf , Edgar Kristin S. , andreassen Åshild K 
Published: November 2021

Abstract
Background: Mosquito-borne viruses pose a serious threat to humans worldwide. There has been an upsurge in the number of mosquito-borne viruses in Europe, mostly belonging to the families Togaviridae (Sindbis, Chikungunya), Flaviviridae (West Nile, Usutu, Dengue), and Peribunyaviridae (Inkoo, Batai, Tahyna). The principal focus of this study was Inkoo (INKV) and Sindbis (SINV) virus circulating in Norway because there is a knowledge gap regarding reservoirs and transmission. Therefore, we aimed to determine the prevalence of SINV and INKV in mosquitoes and seroprevalence of INKV in semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus).Methods: In total, 213 pools containing about 25 mosquitoes each and 480 reindeer sera were collected in eight Norwegian reindeer summer pasture districts during 2013-2015. The mosquito pools were analysed for INKV and SINV RNA, with reverse transcriptase (RT)-real time quantitative PCR (RT-qPCR), and pyrosequencing. Reindeer sera were analysed for INKV-specific IgG by Indirect Immunofluorescence Assay (IIFA) and Plaque Reduction Neutralization Test (PRNT).Results: Aedes spp. were the most dominant species among the collected mosquitoes. Two of the mosquito pools were positive for INKV-RNA by RT-PCR and were confirmed by pyrosequencing. The overall estimated pool prevalence (EPP) of INKV in Norway was 0.04%. IgG seroprevalence in reindeer revealed 60% positive for INKV by IIFA. Of the 55 borderline reindeer sera, 24% were positive on cytopathic effect (CPE)-neutralization test. Among 80% of 60 reindeer sera analysed with PRNT for INKV had a titre ≥ 20, and there was no cross-reactivity with the closely related Tahyna virus (TAHV) and Snow Shoe Hare virus (SSHV). None of the analysed mosquito pools were positive for SINV.Conclusions: The occurrence and prevalence of INKV in Aedes mosquitoes and its high seroprevalence among semi-domesticated reindeer in Norway indicate that further studies are required for monitoring this virus. SINV was not detected in the mosquitoes in this study, however, human cases of SINV infection have yearly been reported from Rjukan. Therefore, it is essential to investigate SINV among human population. Our findings are important to raise awareness regarding the geographical distribution of these mosquito-borne viruses in Northern Europe.
Impact of CCI on Performance Analysis of Downlink Satellite-Terrestrial Systems: Outage Probability and Ergodic Capacity Perspective
Authors: Nguyen Nhat-Tien , Nguyen Hong-Nhu , Le Anh-Tu , Nguyen Nhan Duc , Do Dinh-Thuan , VOZNAK MIROSLAV 
Published: November 2021

Abstract
The evolution of non-orthogonal multiple access (NOMA) has raised many opportunities for massive connectivity with less latency in signal transmissions at great distances. Power-Domain NOMA transmits user signals superimposed in the same resource block by varying the power coefficient of each user according to their channel state information (CSI). At the receiver’s end, successive interference cancellation (SIC) is performed to extract the desired signal from the superimposed signal. Imperfect CSI should therefore be studied in this context. Satellite-terrestrial networks and relay networks have already gained significance in the field of communications through their efficient data transmission techniques. We aimed to integrate NOMA with a satellite communications network under both imperfect CSI and co-channel interference (CCI) from nearby systems with respect to analysis of ground user performance. In our considered system, two users perform downlink communications under Power-Domain NOMA. We analyzed the performance of this system with two modes of shadowing effect: Heavy Shadowing (HS) and Average Shadowing (AS). Performance was analyzed in terms of the outage probability and ergodic capacity of the system. We derived closed-form expressions and performed a numerical analysis. We discovered that the performance of two destinations depends on the strength of the transmit power at the satellite. However, floor outage occurs because the system depends on other parameters, such as satellite link modes, noise levels, and the number of interference sources. More specifically, if, for example, the number of interference sources is 5, the outage performance of the system experiences a decrease of approximately 40% at a signal to noise ratio (SNR) of 30 dB at the satellite. Outage probability and ergodic capacity became saturated at SNRs of 50 dB and 45 dB, respectively. To verify the authenticity of the derived closed-form expressions, we also performed Monte-Carlo simulations.
Transcriptome analysis reveals the prognostic and immune infiltration characteristics of glycolysis and hypoxia in head and neck squamous cell carcinoma
Authors: Liu Jun , Lu Jianjun , Li Wenli 
Published: November 2021

Abstract
Background
This study aims to construct a new prognostic gene signature based on cancer hallmarks for patients with Head and neck squamous cell carcinoma (HNSCC).
Method
The transcriptome profiling data and hallmark gene sets in the Molecular Signatures Database was used to explore the cancer hallmarks most relevant to the prognosis of HNSCC patients. Differential gene expression analysis, weighted gene co-expression network analysis, univariate COX regression analysis, random forest algorithm and multiple combinatorial screening were used to construct the prognostic gene signature. The predictive ability of gene signature was verified in the TCGA HNSCC cohort as the training set and the GEO HNSCC cohorts (GSE41613 and GSE42743) as the validation sets, respectively. Moreover, the correlations between risk scores and immune infiltration patterns, as well as risk scores and genomic changes were explored.
Results
A total of 3391 differentially expressed genes in HNSCC were screened. Glycolysis and hypoxia were screened as the main risk factors for OS in HNSCC. Using univariate Cox analysis, 97 prognostic candidates were identified (P<0.05). Top 10 important genes were then screened out by random forest. Using multiple combinatorial screening, a combination with less genes and more significant P value was used to construct the prognostic gene signature (RNF144A, STC1, P4HA1, FMNL3, ANO1, BASP1, MME, PLEKHG2 and DKK1). Kaplan-Meier analysis showed that patients with higher risk scores had worse overall survival (p <0.001). The ROC curve showed that the risk score had a good predictive efficiency (AUC> 0.66). Subsequently, the predictive ability of the risk score was verified in the validation sets. Moreover, the two-factor survival analysis combining the cancer hallmarks and risk scores suggested that HNSCC patients with the high hypoxia or glycolysis & high risk-score showed the worst prognosis. Besides, a nomogram based on the nine-gene signature was established for clinical practice. Furthermore, the risk score was significantly related to tumor immune infiltration profiles and genome changes.
Conclusion
This nine-gene signature associated with glycolysis and hypoxia can not only be used for prognosis prediction and risk stratification, but also may be a potential therapeutic target for patients with HNSCC.
Sex Specific Differences in Nosocomial Infections in Patients with Decompensated Liver Cirrhosis
Authors: Griemsmann Marie , Tergast Tammo L. , Simon Nicolas , Kabbani Abdul-Rahman , Manns Michael P. , Wedemeyer Heiner , Cornberg Markus , Maasoumy Benjamin 
Published: November 2021

Abstract
Background and aims: There are considerable differences between males and females regarding the etiology, progression and outcome of liver diseases. Infections are a frequent and severe complication in these patients. This study aimed to examine sex specific differences in the incidence and clinical course of nosocomial infections in patients with decompensated liver cirrhosis.Methods: A number of 555 consecutive patients with decompensated liver cirrhosis and ascites were analyzed. The patients were followed up for the incidence of nosocomial infections, acute kidney injury (AKI), acute-on-chronic liver failure (ACLF) as well as liver transplantation and death (LTx-free survival). Results: A number of 285 patients (111 women and 174 men) developed a nosocomial infection. Incidence was numerically lower in men (p=0.076). While the frequency of a nosocomial spontaneous bacterial peritonitis was similar between males and females, the incidence of a nosocomial urinary tract infection was significantly higher in women (p<0.001). No sex specific differences were documented regarding the outcome of an infection as indicated by a similar incidence of, AKI, ACLF as well as LTx-free survival.Conclusion: There seem to be no major differences in the incidence and outcome of nosocomial infections between male and female patients.
Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome
Authors: Gehlert Sebastian , Weinisch Patrick , Römisch-Margl Werner , Jaspers Richard T. , Artati Anna , Adamski Jerzy , Dyar Kenneth A. , Aussieker Thorben , Jacko Daniel , Bloch Wilhelm , Wackerhage Henning , Kastenmüller Gabi 
Published: November 2021

Abstract

Resistance training promotes metabolic health and stimulates muscle hypertrophy, but the precise routes by which resistance exercise (RE) conveys these health benefits is largely unknown. Aim: To investigate how acute RE affects human skeletal muscle metabolism. Methods: We collected vastus lateralis biopsies from six healthy male untrained volunteers at rest, before the first of 13 RE training sessions, and 45 min after the first and last bouts of RE. Biopsies were analysed using untargeted mass spectrometry-based metabolomics. Results: We measured 617 metabolites covering a broad range of metabolic pathways. In the untrained state RE altered 33 metabolites, including increased 3-methylhistidine and 1-carboxylethylvaline, suggesting increased protein breakdown, as well as metabolites linked to ATP (xanthosine) and NAD (N1-methyl-2-pyridone-5-carboxamide) metabolism; the bile acid chenodeoxycholate also increased in response to RE in muscle opposing previous findings in blood. Resistance training led to muscle hypertrophy, with slow type I and fast/intermediate type II muscle fibre diameter increasing by 10.7% and 10.4%, respectively. Comparison of post-exercise metabolite levels between trained and untrained state revealed alterations of 46 metabolites, including decreased N-acetylated ketogenic amino acids and increased beta-citrylglutamate which might support growth. Only five of the metabolites that changed after acute exercise in the untrained state were altered after chronic training, indicating that training induces multiple metabolic changes not directly related to the acute exercise response. Conclusion: The human skeletal muscle metabolome is sensitive towards acute RE in the trained and untrained states and reflects a broad range of adaptive processes in response to repeated stimulation.
High-resolution genetic map construction and QTL analysis of important fiber traits in kenaf using RAD-seq
Authors: Hui Li , Li Chang , Huijuan Tang , Mingbao Luan , Gen Pan , Siqi Huang , Hui Jiang , Yena Wu , Anguo Chen 
Published: November 2021

Abstract
Quantitative trait locus (QTL) mapping is a useful method for revealing the mechanism of complex genetic traits and identifying new genomic information to accelerate crop improvement. In the present study, 154 F2:3 strains and their parents were used for restriction site-associated DNA sequencing, single-nucleotide polymorphism (SNP) identification, and genetic map construction. After filtering based on stringent filtering standards, 297.5 Gb of clean data were obtained. Further, 5,191 polymorphic SNP markers were identified from each sample, of which 1,997 polymorphic SNP markers were successfully mapped onto 18 different linkage groups. Six QTLs (QPH, QFBW, QDBW, QFW, QFT, and QFC) were identified based on the genetic map using the multiple QTL mapping (MQM) method, which were then assigned to three linkage groups, LG16, LG8, and LG3. QPH, QFBW, QDBW, and QFW were related to fiber yield, while QFT and QFC were related to fiber quality. This is the first study of its kind to map QTL of fiber yield and fiber quality, which will facilitate further understanding of the molecular genetic basis of these traits. However, there are limitations regarding the utilization of this map because several large gaps remain in some linkage groups. Therefore, additional markers need to be developed to further narrow these regions.