bluuebunny/crossref_metadata_2025_split huggingface dataset:
The elusive magnetic ground state of sodium superoxide (NaO2)
Authors: Biswas Sarajit , De Raychaudhury Molly 
Published: August 2021

Abstract
An alternative energy storage solution to Li-ion batteries is a higher alkali metal superoxide, namely NaO2. It is well-known that the transport properties of this alkali superoxide are governed by the transfer of charge between O2 dimers. Although it goes through a plethora of structural phase transitions, its electronic and magnetic ground state remains shrouded. In this work, we perform first-principles density functional theory (DFT) calculations in order to understand the electronic structure, the source of the ‘unconventional’ magnetic properties and its effect on conductivity in Na superoxide. Finally, we explore the connection between magnetogyration and the magnetic ground state of NaO2 remaining undetected till date.
Rare Disease Healthcare Experience: Qualitative Survey and Workshop Findings in the Context of UK Policy Development
Authors: Jones Jennifer , Simpson Amy , Meade Nick , Pushparajah Daphnee , Newman David , Hunter Amy 
Published: August 2021

Abstract
Background: the UK Rare Diseases Framework is the latest policy initiative that aims to improve healthcare for rare diseases in the UK, with four priorities focussed on faster diagnosis, increasing awareness among healthcare professionals, better care coordination and improved access to specialist care and treatment. A survey of over 1,000 people living with rare diseases in the UK immediately prior to the publication of the Framework captured quantitative and qualitative data about their experiences. The qualitative analysis is presented here and compared with the content of the Framework.Results: People living with a rare condition in the UK continue to have very mixed experiences of healthcare and our findings illustrate substantial continuing unmet needs that fall under each of the four priorities of the Framework. Conclusions: Comparing the findings with what is emphasised in the Framework suggests specific key changes to policy and practice which might be missed by action plans developed under the Framework. The overall provision in the UK for people living with rare conditions needs to be improved and regularly reviewed, to ensure they are not being unfairly excluded from appropriate diagnosis, treatment or support.
Management of elderly traumatic ankle arthritis with Ilizarov External Fixation: A Retrospective Study
Authors: Li Jun , Wang Wenzhao , Yang Hai , li Bohua , Li Mingxin , Liu Lei 
Published: August 2021

Abstract
Objective To evaluate the clinical effect of Ilizarov external fixation and ankle arthrodesis in the treatment of elderly traumatic ankle arthritis.Methods From June 2015 to August 2019, 72 patients with elderly traumatic ankle arthritis were treated with arthrodesis through Ilizarov external fixation technique in our institution, 38 cases were males and 34 cases were females, with an average of 65.4 years (ranging from 60 to 74). Conventional double-feet loading positive and lateral X ray films were taken before operation. Angle between the tibia anatomic axis and the line segment of inside and outside of talus vertex was measured to evaluate the degree of talipes varus and valgus. Functional assessments were performed using Foot and Ankle pain score of American Orthopedics Foot and Ankle Society(AOFAS) and Visual Analogue Scale(VAS) .Results All of the patients acquired effective postoperative 18-49 months follow-up, with an average of 31.5 months. All ankles achieved bony fusion, the clinical healing time was 12.7 weeks on average(11~18 weeks).The AOFAS score was 45.36±6.43 preoperatively and 80.25±9.16 at 12 months post operation, with a statistically significant difference(P<0.0001). The VAS score was 8.56±1.85 on average preoperatively and 2.72±0.83 at 12 months post operation, with a statistically significant difference ( P<0.0001). The angle of anatomical tibial shaft and the line segment of inside and outside of talus vertex on X-ray image was 101.93°±4.12° preoperatively and 94.45°±2.37° at 12 months post operation, with a statistically significant difference(P<0.0001). The results of functional evaluation indicated that 44 patients(61.1%) had excellent results, 18 (25%) had good results, and 10 (13.9%) had fair results.Conclusion Satisfactory curative effect can be obtained through Ilizarov external fixation and ankle arthrodesis in the treatment of elderly traumatic ankle arthritis.
Effect of Mn On The Performance and Mechanism of Catalysts For The Synthesis of (Ce,La)CO3F
Authors: Li Na , Chen Zedong , Hou Liming , Jiao Kunling , WU Wenfei 
Published: August 2021

Abstract
In accordance with the cerium-lanthanum ratio of fluorocerium ores in the mineralogy of the Baiyun Ebo process, pure substances such as Ce(NO3)3·6H2O, La(NO3)3·6H2O were used to synthesize (Ce,La)CO3F grains to simulate bastnaesite minerals by hydrothermal method, and used as NH3-SCR denitrification catalysts. After being roasted at a series of different temperatures, the catalyst surface produced a well-crystallised Ce7O12 species as the active component for denitrification. The activity results showed that the synthetic (Ce,La)CO3F was roasted at 500°C, and the NOx conversion was 27% at 200°C. The NH3-SCR catalytic activity of the synthesised (Ce,La)CO3F was improved by loaded transition metal Mn. The best catalyst was found to be produced by impregnating (Ce,La)CO3F with 1 mol/L manganese nitrate solution, with a NOx conversion of 80% at 250°C. The physicochemical properties were analysed using XRD, BET, H2-TPR, NH3-TPD and XPS. The loading of Mn resulted in the appearance of numerous well-dispersed MnOx species on the catalyst surface, the dispersion of Ce7O12 species was also greatly enhanced, and the reduction in grain size indicated that Mnn+ entered into the (Ce,La)CO3F lattice causing lattice shrinkage. The number of acidic sites on the catalyst surface and the redox capacity were enhanced. The amount of Ce3+ in the catalyst was also enhanced by the introduction of Mnn+, but the proportion of adsorbed oxygen decreased, which indicated that the introduction of Mnn+ was detrimental to the increase in the proportion of adsorbed oxygen. The reaction mechanisms of the (Ce,La)CO3F and Mn/(Ce,La)CO3F catalysts were investigated by in-situ Fourier transform infrared spectroscopy (FTIR), to provide theoretical guidance for the specific reaction pathways of bastnaesite in the NH3-SCR reaction. The results showed that catalysts followed both the E-R and L-H mechanisms throughout the reaction process. When loaded with Mn, the main reactive species in the L-H mechanism were the NH4+(ad) species on the Brønsted acidic site and the O-Ce3+-O-NO, O-Mn3+-O-NO species. The main reactive species for the E-R mechanism were NH3/NH4+(ad) species on the Brønsted/Lewis acidic sites and NO. The NH4+ (ad) species on the Brønsted acidic sites act as the main reactive NH3(g) adsorbing species, bonded to the Ce4+ in the carrier (Ce,La)CO3F to participate in the acid cycle reaction. The introduction of Mnn+ increases the number of Brønsted acidic sites on the catalyst surface, and acts as an adsorption site for NO, to react with NO to generate more monodentate nitrate species, to participate in the redox cycle reactions. The above results indicated that Mnn+ and (Ce,La)CO3F have a good mutual promotion effect, which makes the loaded catalyst have excellent performance, which provides a theoretical basis for the high value utilization of bastnaesite.
Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats
Authors: Palacios José L. , Juárez Ricardo , Mirto-Aguilar Nancy , Munoz Alvaro , Damaser Margot S. , Cruz Yolanda 
Published: August 2021

Abstract
The aims of the study were to determine the time-course of urinary incontinence recovery after vaginal distension (VD), elucidate the mechanisms of injury from VD leading to external urethral sphincter (EUS) dysfunction, and assess if transcutaneous electrical stimulation (TENS) of the dorsal nerve of the clitoris facilitates recovery of urinary continence after VD. Rats underwent 4-h VD, 4-h sham VD (SH-VD), VD plus 1-h DNC TENS, and VD plus 1-h sham TENS (SH-TENS). TENS or SH-TENS were applied immediately and at days 2 and 4 post-VD. Micturition behavior, urethral histochemistry and histology, EUS and nerve electrophysiology, and cystometrograms were evaluated. VD induced urine leakage and disrupted EUS fibers and nerve-conduction. Urine leakage disappeared 13 days post-VD. Structural and functional recovery of the EUS neuromuscular circuitry started by day 6 post-VD but did not fully recovered by day 11 post-VD. TENS significantly decreased the frequency of urine leakage post-VD (p<0.01). We conclude that rat urinary continence function after VD requires 2 weeks to recover, although urethra structure is not fully recovered. Treatment to facilitate neuroregeneration should be applied within one-week after damage. TENS facilitated urinary continence recovery after VD. This treatment may have potential to decrease postpartum urinary incontinence in women.
Incidence of Transfusion-Related Acute Lung Injury Temporally Associated With Solvent/Detergent Plasma Use In The ICU - A Retrospective Before and After Implementation Study
Authors: Klanderman Robert , Mourik Niels van , Eggermont Dorus , Peters Anna-Linda , Tuinman Pieter-Roel , Bosman Rob , Endeman Hendrik , Cremer Olaf L. , Arbous Sesmu M , Vlaar Alexander P.J. 
Published: August 2021

Abstract
Background: Transfusion-related acute lung injury (TRALI) is a severe complication of plasma transfusion, though use of solvent/detergent pooled plasma (SDP) has nearly eliminated reported TRALI cases. The goal of this study was to investigate TRALI incidence in the intensive care unit (ICU) following replacement of quarantined, male-only, fresh frozen plasma (qFFP) by SDP for routine use. Methods:We conducted a retrospective multicenter observational before-after cohort study during two six-month periods, before (April to October 2014) and after introduction of SDP (April to October 2015), taking into account a six-month wash-out period. One secondary and four tertiary academic hospitals participated.Results:Admitted to the ICU were 8944 patients during both inclusion periods. 1171 qFFP units were transfused in 376 patients in the qFFP, and 396 during the before and after periods respectively in the SDP period. A full patient chart review was performed in 300 patients that received ≥1 units of plasma and had a PaO2/FiO2-ratio (P/F-ratio) <300 within 24 hours. Ten cases of TRALI occurred during the qFFP and nine cases during the SDP period, in which plasma was transfused concomitantly with other products, or alone. The incidence was 0.85% (CI95%: 0.33% – 1.4%) per unit qFFP and 0.45% (CI95%: 0.21% - 0.79%, p = 0.221) per SDP-unit. One instance of TRALI occurring after a single SDP unit. Mortality was 70% for patients developing TRALI in the ICU compared to 22% in all patients receiving at least one plasma transfusion. Conclusion:Implementation of SDP lowered the incidence of TRALI in which plasma products were implicated, though not significantly. TRALI can still occur as a result of SDP transfusion. Developing TRALI in the ICU was associated with high mortality rates, therefore clinicians should remain vigilant.
Post-Ebola Sequelae Among Child Ebola Survivors in Sierra Leone
Authors: Amuzu Claudette , James Peter Bai , Bah Abdulai Jawo , Bayoh Alex Vandy Saffa , Singer Shepherd Roee 
Published: August 2021

Abstract
Introduction

: There is limited data regarding the long-term health effects of child survivors of the 2013–2016 West African Ebola virus disease (EVD) outbreak. Here, we assess post-Ebola complications among EVD child survivors by comparing the self-reported symptoms between EVD child survivors and their close household contacts over one year after the end of the outbreak.
Methods

Child EVD survivors(n = 159) and their close contacts(n = 303) were enrolled in Western and Eastern Sierra Leone. Demographic and self-reported symptoms data were collected using an interviewer-administered questionnaire. We compared a list of self-reported symptoms between EVD child survivors and their close household contacts using backward stepwise logistic regression.
Results

Child EVD survivors were more likely to be orphans compared to their controls. Musculoskeletal, ocular, auditory and neurological symptoms were more prevalent among Ebola survivors than their close contacts (p < .001). Joint pain and headache were the most common self-reported symptoms, and child survivors and their contacts. Joint pain (AOR = 2.633; 95% CI1.313-5.278, p = 0.006), eye pain (AOR = 4.559,95%CI: 2.156–9.639, p < 0.001) hearing loss (AOR = 3.849, 95%CI: 1.151–12.871, p = 0.029), memory impairment (AOR = 7.763,.95%CI: 1.339–45.007 p = 0.022), mood changes (AOR = 5.070, 95%CI: 2.350-10.939, p < 0.001) were more common among survivors than their contacts.
Conclusion

Our data suggest that child EVD survivors have higher odds than their close contacts to suffer from post-Ebola musculoskeletal, ophthalmic, auditory and neurological impairment more than a year after the end of the EVD outbreak. Routine screening, treatment and monitoring of these symptoms is required to prevent long-term disability among child Ebola survivors.
In vitro anti-cancer effect of Crataegus oxyacantha berry extract on hormone receptor positive and triple negative breast cancers via regulation of canonical Wnt signalling pathway
Authors: K Salini , Sivasithamparam Niranjali Devaraj 
Published: August 2021

Abstract
Breast cancer treatment strategy depends mainly on the receptor status. Our aim was to identify a herbal preparation, effective against breast cancer, irrespective of hormone sensitivity, and to understand its molecular mechanism. The rich antioxidant composition of Hawthorn ( Crataegus oxyacantha ) makes it a promising anti-cancer drug candidate. Polyphenol-rich methanolic extract of C. oxyacantha berry (M.Co) was found to be cytotoxic on hormone receptor positive (MCF-7) and triple negative (MDA-MB-231) breast cancer cell lines, at a dose (75 mg/ml) safe on normal cells. It could effectively inhibit tumor cell proliferation and arrest cell cycle at G1/S transition in both cell lines. Molecular targets were selected from different levels of canonical Wnt signalling pathway (such as autocrine and antagonistic ligands, receptor, effector, cytoplasmic components, downstream targets and pathway antagonist), since they are frequently found dysregulated in all breast cancers and their aberrant activation is associated with cancer stem cell expansion. M.Co could significantly downregulate the expression of Wnt pathway agonists and upregulate that of Wnt antagonists at transcriptional and translational levels, in both cell lines. To conclude, C. oxyacantha berry extract is effective against breast cancer irrespective of its hormone dependency and cancer growth inhibition at stem cell level can be expected.
Youtube English videos as a source of information on shoulder exercise after breast cancer surgery
Authors: Guloglu Selen , Ozdemir Yunus , Basim Pelin , Tolu Sena 
Published: August 2021

Abstract
Purpose

To examine the content, quality and reliability of YouTube videos on exercises that can be performed after breast cancer surgery.

Methods

Videos selected from YouTube using the search terms “shoulder exercise and breast cancer surgery”, “arm exercise and breast cancer surgery”, and “physiotherapy/physical therapy and breast cancer surgery” were categorized as useful or misleading by a doctor and a physiotherapist. The videos were analyzed using the five-point DISCERN scale for reliability, the five-point Global Quality Scale (GQS) for quality, and a 10-item scale for comprehensiveness.

Results

Of the 180 videos initially analyzed, 82 were included in the study, and 42 (51.2%) were classified as having misleading information and 40 (48.8%) as having useful information. The reliability, content and quality scores of the videos containing useful information were higher (p<0.001). Most of the videos in the useful information group (80%) were uploaded by universities/professional organizations/physicians/physiotherapists, while the majority of those in the misleading information group (47.6%) were uploaded by websites providing independent healthcare information. The total and daily views of the videos were higher in the useful information group than in the misleading information group (p<0.001 and p=0.004, respectively). When the video parameters were evaluated between the two groups, no significant difference was found in the number of likes and comments and video length.

Conclusion

YouTube can be an important instrument to protect patients from musculoskeletal system complications after breast cancer surgery and improve existing complications. Universities, physicians, and physiotherapists should be encouraged to prepare more videos containing full and accurate information on this subject.
Essential Stressing State Features of Laterally Loaded Masonry Wall Panels Revealed from Experimental Displacements
Authors: Liu Bai , Li Rui , Zhang Yu , Zhou Guangchun 
Published: August 2021

Abstract
This study reveals the essential and general working features of laterally loaded masonry (LLM) wall panels from their experimental displacements by applying structural stressing state theory. Firstly, the generalized work of force is proposed to express the stressing state mode and its characteristic parameter. Then, the Mann-Kendall criterion is applied to detect the mutation point in the curve of the characteristic parameter with the load increase. Correspondingly, it is verified that the evolution of the stressing state mode also embodies the mutation feature. The stressing state mutation feature is inherent and common as the embodiment of the natural law from quantitative change to qualitative change of a system. The stressing state mutation feature reveals the starting point of structural failure process, which could update the existing definition of structural failure load. Further, the elastoplastic branch (EPB) point is revealed referring to the updated failure load, which might be directly taken as the design load with the rational margin of safety. In a sense, this paper presents a new way to address the classic issue of structural load-bearing capacity uncertainty and to update the existing design codes of LLM wall panels.
Swedish healthcare for women subjected to Female Genital Mutilation/Cutting (FGM/C)
Authors: Akhavan Sharareh 
Published: August 2021

Abstract
Background: FGM/C can lead to a number of health complications, such as pain during intercourse or childbirth, psychological problems, and postpartum complications. This study seeks to describe and assess Swedish healthcare for women subjected to FGM/C.Methods: This aim encompasses three research foci: (1) to inventory Swedish regional healthcare guidelines and policies for care for women who have undergone FGM/C, (2) to map healthcare consumption among women who have undergone FGM/C, and (3) to map the type of care measures and treatment they have been offered in the Swedish healthcare system. A questionnaire was sent to healthcare regional managers and a database study was conducted.Results: The inventory of the healthcare regions' guidelines shows that five of 21 had no guidelines. The number of women who have been subjected to FGM/C and sought care has increased steadily between 2012 and 2018. Women who have been subjected to FGM/C seek care mostly in connection with pregnancy and childbirth.Conclusions: The type of care that should be offered to women who have been subjected to FGM/C vary depending on individual needs. Care may include surgical procedures in the form of defibulation, clitoral reconstruction, or removal of cysts, as well as psychosexual care. Existing treatment options in surgical care, together with psychosexual treatment, are the care measures that seem to be helpful for some women who have undergone FGM/C, but not for all. Communication and treatment are of great importance in order to be able to offer care to women who have undergone FGM/C.
Infections caused by the Delta variant (B.1.617.2) of SARS-CoV-2 are associated with increased viral loads compared to infections with the Alpha variant (B.1.1.7) or non-Variants of Concern.
Authors: von Wintersdorff Christian , Dingemans Jozef , Alphen Lieke van , Wolffs Petra , Veer Brian van der , Hoebe Christian , Savelkoul Paul 
Published: August 2021

Abstract
There has been a growing body of evidence that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant (B.1.617.2) shows enhanced transmissibility and increased viral loads compared to other variants. A recent study has even suggested that respiratory samples from people infected with the Delta variant can harbor up to 1000 times higher viral loads compared to samples with variants that are more closely related to the original Wuhan strain, although the sample size of this study was very limited. Here, we have compared the viral load in 16,185 samples that were obtained during which non-VOC, the Alpha (B.1.1.7) or Delta variant (B.1.617.2) were dominant as evidenced by genomic surveillance. We found that the Delta variant contained about 4-fold higher viral loads compared to the non-VOC or Alpha variants.
Sleep duration during COVID-19 lockdown: systematic review and meta-analysis
Authors: Stukalin Yelena , Lan Anat , Kronfeld-Schor Noga , Shmueli Erez , Einat Haim 
Published: August 2021

Abstract
In attempts to slow down the spread of COVID-19 pandemic, countries took different measures including lockdowns. Several studies reported the effects of lockdowns on sleep mostly suggesting an increase in sleep duration during lockdowns. This is an interesting outcome as life in the modern world were associated with insufficient sleep. The present study is a systematic review and meta-analysis of work regarding sleep duration during lockdowns. We searched PubMed using the terms “COVID-19”, “SARS-CoV-2”, “lockdown”, “stay at home”, “quarantine” and “sleep” and found 262 papers. After applying exclusion criteria, we identified 26 papers (with 35 discrete studies) for the meta-analysis. A fixed effect model was used with effect sizes estimated using Cohen’s d and heterogeneity of effect sizes tested using the Cochran’s Q test statistics. Most studies (31/35) report an increase in sleep duration during lockdown periods with a mean (± STD) of 31.5 ± 21.2 minutes. Effect sizes (Cohen’s d) ranged between 0.08 and 3.34, which are considered between very small and huge. Q statistics was 4859.3 (p < 0.0001) and with no indication for publication bias (Egger’s test, p = 0.45). Eight studies also reported measures of “sleep quality” with 6/8 reporting worsening of sleep quality with small to large effect sizes Cohen’s d range between 0.09 and 1.86). The study demonstrates increased sleep duration during lockdowns. Increased sleep duration is a positive change, but effects on well-being during lockdowns might be overshadowed by reduced sleep quality, increased stress, and lowered mood. It is interesting whether longer sleep duration habits may survive to post-COVID-19 days.