bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant food consumption and emotional well-being: the Helsinki Health Study among 19–39-year-old employees
Authors: Mauramo Elina , Lallukka Tea , Kanerva Noora , Salmela Jatta 
Published: December 2024

Abstract
Background and objectives
Associations between fruit and vegetable consumption and mental health have been observed, but studies comparing different types of plant foods are sparse. This study among Finnish municipal employees examined associations of the consumption of a range of different plant foods with emotional well-being (EWB).

Data and methods
We used survey data from the Helsinki Health Study conducted in 2017 among 19–39-year-old employees of the City of Helsinki, Finland (N = 5898, response rate 51.5%, 80% women). Consumption of plant foods, including fruit, berries, fresh and cooked vegetables and wholegrain bread, was measured by a food frequency questionnaire and dichotomised into daily/non-daily consumption. The EWB scale of the RAND-36 questionnaire was dichotomised, with the lowest quartile indicating ‘poor EWB’ and the three higher quartiles indicating ‘good EWB’. We used logistic regression for analysing the associations between plant food consumption and EWB. Analyses were sex-stratified and age, socioeconomic circumstances and psychosocial working conditions were adjusted for.

Results
Prevalence of daily consumption of plant foods varied from 25% for berries and cooked vegetables to 70% for fresh vegetables. Daily consumption was associated with good EWB among both women and men. The strongest age-adjusted association was found for fresh vegetables, with women (OR 1.48, 95% CI 1.27–1.74) and men (OR 1.86, CI 1.37–2.52) with daily consumption having clearly higher odds of good EWB compared to non-daily consumers. Associations slightly attenuated but mostly remained after adjusting for socioeconomic circumstances and working conditions.

Conclusions
More frequent plant food consumption was associated with good EWB. Thus, the results support the need for interventions that investigate whether the promotion of plant food consumption could show potential mental health benefits among employees.
Establishment of an oral burn model in streptozotocin-induced diabetic rats
Authors: Kim Su-Young , Kim Seong-Gon , Kim Dae-Won , Oh Ji-Hyeon 
Published: December 2024

Abstract
Background
Oral ulcers are painful mucosal lesions prone to infection and inflammation. To evaluate the effectiveness of treatments, a suitable experimental animal model with an appropriate healing period is required. The aim of this study was to develop an animal model for oral ulcer research by comparing oral burn wounds of different sizes and locations in diabetic rats.

Methods
Forty-four male Sprague–Dawley rats with induced diabetes were divided into six groups based on burn wound location and size: T5 (n = 10, tongue 5 mm), T3 (n = 10, tongue 3 mm), P5 (n = 10, palate 5 mm), P3 (n = 10, palate 3 mm), CT (n = 2, control tongue), and CP (n = 2, control palate). The burn wounds were induced by applying a heated device (100–120 °C) for 3 s. At 1- and 2-weeks post-surgery, macroscopic examination, histological staining, immunohistochemistry, and Western blot analysis were performed to compare the healing progress.

Results
Healing progressed more rapidly in the second week than in the first for all groups, with burns on the tongue (Groups T5 and T3) showing more advanced healing compared to burns on the palate (Groups P5 and P3). By the second week, Group T3 was almost completely healed, while Group T5 had some remaining wounds. In contrast, Groups P5 and P3 showed minimal healing. This faster healing on the tongue was further supported by significantly lower expression levels of TNF-α and IL-1β and a reduction in ulcer size, particularly on the tongue compared to the palate.

Conclusion
A 3 mm or 5 mm burn wound on the tongue of diabetic rats can serve as a useful animal model for evaluating new treatments for wound healing, particularly up to the first week. However, for studies extending to the second week, the 5 mm burn wound model on the tongue might be more advantageous.
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study
Authors: Fan Mingyuan , Yun Zhangjun , Yuan Jiushu , Zhang Sai , Xie Hongyan , Lu Dingyi , Yuan Haipo , Gao Hong 
Published: December 2024

Abstract
Background
Considering that the treatment of gout is poor, we performed a Mendelian randomization (MR) study to identify candidate biomarkers and therapeutic targets for gout.

Methods
A drug-targeted MR study was performed for gout by integrating the gout genome-wide association studies (GWAS) summary data and cis expression quantitative trait loci of 2,633 druggable genes from multiple cohorts. Summary data-based Mendelian randomization (SMR) analyses based on transcript and protein levels were further implemented to validate the reliability of the identified potential therapeutic targets for gout. Phenome-wide MR (Phe-MR) analysis was conducted in 1403 diseases to investigate incidental side effects of potential therapeutic targets for gout.

Results
Eight potential therapeutic targets (ALDH3B1, FCGR2B, IL2RB, NRBP1, RCE1, SLC7A7, SUMF1, THBS3) for gout were identified in the discovery cohort using MR analysis. Replication analysis and meta-analysis implemented in the replication cohort validated the robustness of the MR findings (P < 0.05). Evidence from the SMR analysis (P < 0.05) further strengthened the reliability of the 8 potential therapeutic targets for gout also revealed that high levels of ALDH3B1 reduced the gout risk possibly modified by the methylation site cg25402137. SMR analysis (P < 0.05) at the protein level added emphasis on the impact of the risk genes NRBP1 and SUMF1 on gout. Phe-MR analysis indicated significant causality between 7 gout causal genes and 45 diseases.

Conclusion
This study identified several biomarkers associated with gout risk, providing new insights into the etiology of gout and promising targets for the development of therapeutic agents.
In vitro evaluation of the physical characteristics and push-out bond strength of new experimental nano-MTA
Authors: Omar Nada , Aly Yousra , Salem Haidy N. 
Published: December 2024

Abstract
Background
This research assessed two materials to be used as endodontic sealing material. The setting time, pH change, calcium ions release, microhardness and push-out bond strength were compared.

Methods
In this in vitro experimental study, comparison was done between: one commercial perforation repair material MTA Angelus and experimental Nano-MTA. For each material, testing for setting time was done using Vicat apparatus, measurement of pH values was established by pH meter, the discharged calcium ions were measured at 1 day, 1 week and 4 weeks post setting via Spectro-photo-meter, three diagonal indentations were created at each specimen surface using Vickers hardness machine. Two groups (n = 10) of maxillary central incisors were used according to the type of root-end filling material. To determine the bond strength, the universal testing apparatus was used. The de-bonded specimens were examined under the stereo-microscope to assess fracture mode.

Results
Nano-MTA and MTA angelus were similar in pH change, setting time and push-out strength records. The nano-MTA group showed significantly higher microhardness and Ca ion release.

Conclusions
Under the parameters of the current investigation, we can conclude that the physical properties of Nano-MTA and commercially available MTA cement (MTA-Angelus) are comparable. Nano-MTA showed higher hardness properties and higher Ca ions release than MTA-Angelus, which could be considered as a potential property to be used as a dentin repair and root-end filling material.
Regional-based potential assessment for solar photovoltaic generation in northern part of Nigeria using satellite imagery data
Authors: Salihu Mohammed K. , Danladi Ali , Medugu D. W. 
Published: December 2024

Abstract
Background
This research used satellite imagery data to conduct a regional-based potential assessment for solar photovoltaic generating in the northern section of Nigeria. The mean annual global solar radiation from satellite image data was calculated and to compare it with meteorological data, the study area’s temperature was ascertained using satellite images. ArcGIS was also used to determine the appropriateness axis for the development of solar photovoltaic stations in the northern part of Nigeria. Photovoltaic technology was utilized to transform the calculated amounts of solar radiation on a global scale into potential electrical energy.

Results
The findings show that the northeast region has the highest annual mean value of global solar radiation (2179.5 kilowatts-hours/square-meter/Year), followed by the northwest region (2137.5 kilowatts-hours/square-meter/Year), and the north central region (1909.6 kilowatts-hours/square-meter/Year). The influence of global solar radiation also caused an increase in temperature. With an area value of 174,886 kilometer-square, the northeast region has the greatest suited axis for the development of solar PV stations, followed by the north central region (145,187 kilometer-square) and the northwest region (127,470 kilometer-square). The greatest photovoltaic technology, single-crystalline silicon (500.5 Gigawatts), is followed by multi-crystalline silicon (462.5 Gigawatts), cadmium-telluride (362.7 Gigawatts), and amorphous-silicon (81.10202.8 Gigawatts), which has the lowest value.

Conclusions
It is discovered that Nigeria’s north receives more solar radiation from the sun than the rest of the country, and that the region has the ability to produce enough electricity to power the entire nation.
Association between BAFF gene polymorphism and systemic lupus erythematosus: a meta-analysis
Authors: Wu Qing , Zhang Qin , Ye Dong-Qing 
Published: December 2024

Abstract
Objective
To inquire into the association from BAFF gene promoter -871C > T single nucleotide polymorphisms (SNP) to the etiopathogenesis of systemic lupus erythematosus (SLE) and to further discuss the interracial differences through ethnostratified methods.

Methods
All researches exploring the link of BAFF gene promoter-871C > T single nucleotide polymorphisms (SNPs) with SLE before February 2023 were retrospectively selected, and the allele frequency was calculated by allele counting.

Results
The study amalgamates data from five independent researches, encompassing a total of 514 cases and 605 controls. A statistically significant correlation is observed in the recessive model (OR = 0.64, 95% CI: 0.50–0.82, P < 0.001), as well as in the allelic model (OR = 0.63, 95% CI: 0.42–0.95, P = 0.026). However, no statistically significant associations are found in the Dominant model (OR = 0.84, 95% CI: 0.59–1.21, P = 0.352), CC vs. TT (OR = 0.70, 95% CI: 0.47–1.03, P = 0.073), and CT vs. TT (OR = 1.04, 95% CI: 0.71–1.53, P = 0.852). Additionally, both the funnel plot and Begg’s test for publication bias indicate no discernible asymmetry, with all P values exceeding 0.05. This suggests an absence of publication bias in the study.

Conclusion
The correlation between BAFF gene promoter polymorphism-871C > T allele frequency and mutant genotype T and SLE risk was demonstrated, and a stronger correlation was found in the population subgroup analysis compared with non-Asians.
ANFIS robust control application and analysis for load frequency control with nonlinearity
Authors: Kumar Krishna , Das Madhulika , Karn Amrendra Kumar 
Published: December 2024

AbstractThis study investigates and demonstrates the adaptive neuro-fuzzy inference system (ANFIS) controller performance on a dynamic system with inherent nonlinearity. Here, dynamics of automatic load frequency control is considered under this case. The ANFIS controller is designed, trained, and optimized to regulate the frequency deviation of an isolated power delivery area. The frequency deviation data under a sample disturbance are taken with the desired control effort and are picked to train with five different membership functions. The tuning is carried out by the hybrid method. The ANFIS controller, developed, yields a better result, with less settling time of up to 20 s than the standard disturbance rejection proportional–integral–derivative (PID) controller takes. Designed ANFIS performs very robustly considering variations in inertia and damping. All the experimental setup is built under a MATLAB Simulink environment.
Neoadjuvant Immunotherapy Followed by Surgery Compared with Upfront Surgery Alone in Operable Colon Cancer with Deficient Mismatch Repair: Modeling Oncological Outcomes and Numbers Needed to Treat
Authors: Kanani Arezo , Veen Torhild , Lea Dordi , Zaharia Claudia , Watson Martin , Alexeeva Marina , Thorsen Kenneth , Søreide Kjetil 
Published: December 2024

Abstract
Background
Trials on neoadjuvant immunotherapy in operable colon cancer with deficient mismatch repair (dMMR) reported high pathological response rates in the surgical specimen, but long-term survival is not known. Neoadjuvant immunotherapy as a stand-alone therapy without subsequent radical surgery is currently not investigated in colon cancer.

Objective
The aim of this study was to model outcomes between trial data and real-world patients after surgery.

Methods
We conducted a comparative modeling study between prospective trial data (NICHE-1) and a prospective, population-derived, translational cohort study (ACROBATICC) of patients with operable colon cancer and microsatellite instability (MSI) status. Comparison was performed across immune-cell infiltrates, stages, MSI, and patient demographics for adverse events, reported oncological outcomes, and modeling numbers needed to treat (NNT) to prevent recurrence.

Results
Patient characteristics between the dMMR tumors in the NICHE-1 (n = 21) and ACROBATICC (n = 43) cohorts differed, with older patients and fewer hereditary dMMRs in the ‘real-life’ ACROBATICC cohort. Higher expression of CD8+ in dMMR tumors compared with proficient mismatch repair (pMMR) tumors was statistically significant across both cohorts. At long-term follow-up, 2/43 patients with dMMR had died from recurrent colon cancer in the ACROBATICC cohort. Assuming a curative effect of neoadjuvant immunotherapy in addition to surgery in dMMR tumors, the NNT would be >20 patients for any additional survivor.

Conclusion
In unselected patients with colon cancer having dMMR, recurrence risk is very low after surgery. Assuming a curative effect of neoadjuvant immunotherapy beyond surgery alone, the NNT would be at least 20 patients to prevent one cancer death over surgery alone.
Alternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women
Authors: Chen Mingxian , Zhang Yuan , Yu Xinkai , Zuo Qun 
Published: December 2024

ABSTRACT

Purpose
Irisin plays an important role in bone-muscle crosstalk. The aim of this study was to elucidate the association of long-term exercise induced irisin response with body composition and bone mineral density in postmenopausal women.

Methods
We recruited 29 postmenopausal women (age: 62.67 ± 3.9 years) without regular exercise habits to participate in a 24-week program of alternating aerobic and resistance training exercise. Blood samples, body composition and bone mineral density were measured before and after exercise intervention.

Results
Upper and lower limb bone density (P = 0.004, P = 0.039), calf circumference (P = 0.001), circulating levels of irisin (P = 0.003) and osteocalcin (P < 0.001) increased by exercise. Whereas, waist circumference (P = 0.000), blood osteoprotegerin (OPG) (P = 0.041), receptor activator of NF-κB ligand (RANKL) (P < 0.001), RANKL/OPG ratio (P < 0.001) and estradiol levels (P = 0.003) decreased by training, respectively. According to the observed changes in the measured variables, the irisin circulating levels were significantly and separately related to upper limb BMD (r = 0.462, P = 0.006), lower limb BMD (r = 0.566, P = 0.001), total BMD (r = 0.490, P = 0.008) and T score of DAX (r = 0.489, P = 0.010). The increase in serum irisin levels was found to be positively and separately related to upper limb BMD (r = 0.414, P = 0.026), total BMD (r = 0.453, P = 0.014), calf circumference (r = 0.400, P = 0.031), and ASM/height2 (r = 0.309, P = 0.031) improvements.

Conclusions
Long-term alternating exercise training improves bone density, body composition and circulating irisin levels in postmenopausal women, and irisin would mediate bone-muscle crosstalk to exert positive effect of exercise on bone health in postmenopausal women.
Inference and Impact of Category Captaincy
Authors: Zhu Xinrong 
Published: December 2024

This paper studies category captaincy, a vertical relationship where retailers delegate shelf placement and pricing decisions of an entire product category to one of the leading manufacturers within that category. These contracts involve preferential treatment given to certain brands within the retailer. However, they are confidential, and empirical analysis has been limited. To study the prevalence and welfare impact of these contracts, I develop a novel approach to infer the presence of captaincy contracts based on preferential treatment in shelf placement and pricing. I first classify retailers into different captaincy types based on a brand × retailer specific quality of shelf placement inferred from a demand model. I then conduct pricing tests and find that captains, in line with theoretical predictions and industry anecdotes, eliminate double markups from their own products but not from competitor products. Comparative statics show that captaincy relationships increase the market share of the captain, but they can also increase consumer welfare by about 5% due to the elimination of double markups on the captain’s products. This paper was accepted by Raphael Thomadsen, marketing. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2023.02039 .
Pengembangan Media Virtual Tour 3D Interaktif sebagai Wahana Promosi Edupreneur Pesantren Teknologi
Authors: Ardianto Okta Putra Setio , Ardiantono Dewie Saktia , Wardhana Mahendra , Kristianto Thomas Ari , Rucitra Anggra Ayu , Budianto Caesario Ari , Sabiela Yaritsa Husni , Sopian Usep , Khairunnisa Nisrina , Ramadhan Ken Nayyara Azkhira , Anjar Byanca Putri , At-Taqi Abdul Muta'ali Muharik 
Published: December 2024

Pesantren teknologi merupakan salah satu bentuk dari inovasi dalam dunia pendidikan islam yang berhasil memadukan nila-nilai agama dengan ilmu pengetahuan dan teknologi sehingga menjadikannya model pembelajaran yang relevan dengan zaman. Meskipun berpotensi besar, pesantren teknologi masih kurang dikenal oleh masyarakat luas. Dengan memanfaatkan dan mengembangkan media virtual tour 3D interaktif sebagai sarana promosi diharapkan dapat membantu mengenalkan pesantren teknologi kepada masyarakat secara menarik dan interaktif. Media virtual tour ini dikembangkan menggunakan aplikasi 360° VR Tour Builder yang memberikan pengalaman kepada penggunanya dalam menjelajahi lingkungan pesantren secara virtual. Tahapan awal yang dilakukan adalah melakukan riset dan pengumpulan data melalui pengambilan gambar dari setiap area melalui perangkat kamera 360° serta melakukan scanning dan mapping area melalui piloted drone. Tahapan selanjutnya merupakan import gambar dan video 360° ke dalam software 360° VR Tour Builder yang dilanjutkan dengan penempatan hotspot interaktif, penambahan informasi setiap lokasi, dan pembuatan peta navigasi. Tahapan akhir adalah integrasi virtual tour ke dalam platform website dengan melakukan pengujian ke berbagai perangkat (desktop, tablet, dan smartphone) untuk memastikan pengalaman optimal bagi pengguna. Pendekatan ini diharapkan para pengelola pesantren dapat memanfaatkannya untuk promosi yang efektif serta dapat meningkatkan visibilitas dan citra pesantren teknologi sebagai lembaga pendidikan islam yang modern dan berkualitas.
Protocol for a single-blind randomized controlled clinical trial to investigate the feasibility and safety of in-bed self-exercises based on electromyography sensor feedback in patients with subacute stroke
Authors: Kim Jung Hyun , Oh Byung-Mo , Seo Han Gil , Hyun Sung Eun , Han Jong tae , Kang Dae hee , Lee Woo Hyung 
Published: December 2024

Background
The dosage and intensity of physical therapy are crucial factors influencing the motor recovery of the hemiplegic lower limb in patients with subacute stroke. Biofeedback using wearable sensors may provide opportunities for patients with stroke to effectively guide self-exercises with monitoring of muscular activities in hemiplegic lower limbs. This study aims to explore the feasibility and safety of in-bed self-exercises based on electromyography sensor feedback in patients with subacute stroke.

Methods
This is a pilot randomized controlled trial comparing conventional physical therapy with additional in-bed self-exercises based on electromyography sensor feedback and conventional physical therapy alone. The interventions will be adjusted according to the muscle strength and Brunnstrom recovery stage in the hemiplegic lower limbs. The primary outcome measure is the Pittsburgh Rehabilitation Participation Scale. The secondary outcome measures include the number and percentage of participating sessions, number and percentage of effortful sessions, number and percentage of successful sessions, mean amplitude of muscle contractions in a session, duration and percentage of participating sessions during self-exercises, Rivermead Motor Assessment, Manual Muscle Test, Brunnstrom recovery stage, Fugl–Meyer assessment, Berg Balance Scale, Functional Ambulation Category, modified Rankin scale, and Short-Form Health Survey 36 version 2.

Results
The results will be described in future studies.

Conclusion
This clinical trial will estimate the feasibility and safety of in-bed self-exercises based on electromyography sensor feedback in patients with subacute stroke. If the expected results are achieved in this study, stroke rehabilitation methods will be enriched.

Trial registration
clinicialtrials.gov, NCT05820815.
Risk factors and predictive model construction for lower extremity arterial disease in diabetic patients
Authors: Kuang Yingjie , Cheng Zhixin , Zhang Jun , Yang Chunxu , Zhang Yue 
Published: December 2024

Objective
To understand the prevalence and associated risk factors of lower extremity arterial disease (LEAD) in Chinese diabetic patients and to construct a risk prediction model.

Methods
Data from the Diabetes Complications Warning Dataset of the China National Population Health Science Data Center were used. Logistic regression analysis was employed to identify related factors, and machine learning algorithms were used to construct the risk prediction model.

Results
The study population consisted of 3,000 patients, with 476 (15.9%) having LEAD. Multivariate regression analysis indicated that male gender, atherosclerosis, carotid artery stenosis, fatty liver, hematologic diseases, endocrine disorders, and elevated glycosylated serum proteins were independent risk factors for LEAD. The risk prediction models constructed using Logistic regression and MLP algorithms achieved moderate discrimination performance, with AUCs of 0.73 and 0.72, respectively.

Conclusion
Our study identified the risk factors for LEAD in Chinese diabetic patients, and the constructed risk prediction model can aid in the diagnosis of LEAD.