bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-grade intracranial meningioma with bilateral pulmonary metastases incidentally detected postpartum: a case report and review of the literature
Authors: Mardani Parviz , Safarian Arash , Ashari Anita , Pourjafar Sarina , Anbardar Mohammad Hossein , Azarpira Negar , Vafabin Masoud , Yousefi Shahaboddin 
Published: October 2021

AbstractIntroductionMeningiomas are the most commonly encountered intracranial tumors, usually showing indolent behavior. Extra-axial spreading and distant metastases are seldom detected in these tumors, and lung metastasis from a low-grade meningioma is a rare event.Case presentationThis case report aimed to present the clinical, imaging, and pathological features of a 37-year-old Caucasian pregnant woman with bilateral lung metastases incidentally detected during preoperative workup ahead of surgery for a primary intracranial meningioma. The possible metastatic routes and risk factors of dissemination to the pulmonary circulation were discussed as well.ConclusionMetastasis must be considered in patients with intracranial meningiomas accompanied by venous sinus invasion and extension through the calvarium. Thorough paraclinical investigations are suggested in such cases.
Supported online cognitive behavioural therapy for bulimia nervosa: a study protocol of a randomised controlled trial
Authors: Barakat Sarah , Touyz Stephen , Maloney Danielle , Russell Janice , Hay Phillipa , Cunich Michelle , Lymer Sharyn , Kim Marcellinus , Madden Sloane , Miskovic-Wheatley Jane , Maguire Sarah 
Published: October 2021

Abstract
Background
Despite the availability of effective treatments for bulimia nervosa (BN), a number of barriers to accessibility exist. Examples include access to trained clinicians, the expense of treatment, geographical limitations, and personal limitations such as stigma regarding help seeking. Self-help interventions, delivered via a digital platform, have the potential to overcome treatment gaps by providing patients with standardised, evidence-based treatments that are easily accessible, cost-effective, and require minimal clinician support. Equally, it is important to examine the shortcomings of digital interventions when compared to traditional to face-to-face delivery (e.g., high dropout rates) in order to maximise the therapeutic effectiveness of online, self-help interventions.

Methods
A three-arm, multisite randomised controlled trial will be conducted in Australia examining the effectiveness and cost-effectiveness of a newly developed online self-help intervention, Binge Eating eTherapy (BEeT), in a sample of patients with full or sub-threshold BN. The BEeT program consists of 10, multimedia sessions delivering the core components of cognitive behaviour therapy. Eligible participants will be randomised to one of three groups: independent completion of BEeT as a purely self-help program, completion of BEeT alongside clinician support (in the form of weekly telemedicine sessions), or waitlist control. Assessments will take place at baseline, weekly, post-intervention, and three-month follow up. The primary outcome is frequency of objective binge episodes. Secondary outcomes include frequency of other core eating disorder behavioural symptoms and beliefs, psychological distress, and quality of life. Statistical analyses will examine treatment effectiveness, feasibility, acceptability and cost effectiveness.

Discussion
There is limited capacity within the mental health workforce in Australia to meet the demand of people seeking treatment for eating disorders. This imbalance has only worsened following outbreak of the COVID-19 pandemic. Further research is required into innovative digital modes of treatment delivery with the capacity to service mental health needs in an accessible and affordable manner. Self-help programs may also appeal to individuals who are more reluctant to engage in traditional face-to-face treatment formats. This study will provide rigorous evidence on how to diversify treatment options for individuals with BN, ensuring more people with the illness can access evidence-based treatment.
The study has been registered with the Australia New Zealand Clinical Trials Registry (ANZCTR Registration Number: ACTRN12619000123145p). Registered 22 January 2019, https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12619000123145.
Minimal residual disease in multiple myeloma: current status
Authors: Ding Hong , Xu Juan , Lin Zhimei , Huang Jingcao , Wang Fangfang , Yang Yan , Cui Yushan , Luo Hongmei , Gao Yuhan , Zhai Xinyu , Pang Weicui , Zhang Li , Zheng Yuhuan 
Published: October 2021

AbstractMultiple myeloma (MM) is a treatable plasma cell cancer with no cure. Clinical evidence shows that the status of minimal residual disease (MRD) after treatment is an independent prognostic factor of MM. MRD indicates the depth of post-therapeutic remission. In this review article, we outlined the major clinical trials that have determined the prognostic value of MRD in MM. We also reviewed different methods that were used for MM MRD assessment. Most important, we reviewed our current understanding of MM MRD biology. MRD studies strongly indicate that MRD is not a uniform declination of whole MM tumor population. Rather, MM MRD exhibits unique signatures of cytogenetic aberration and gene expression profiles, unlike those of MM cells before therapy. Diagnostic high-risk MM and low-risk MM exhibited a diversity of MRD features. Clonal evaluation may occur at the MRD stage in MM. The dynamics from the diagnostic MM to MRD correlate with the disease prognosis. Lastly, on the aspect of omics, we performed data-based analysis to address the biological features underlying the course of diagnostic-to-MRD MM. To summarize, the MRD stage of disease represents a critical step in MM pathogenesis and progression. Demonstration of MM MRD biology should help us to deal with the curative difficulties.
Contextual polarity and influence mining in online social networks
Authors: Alzahrani Hassan , Acharya Subrata , Duverger Philippe , Nguyen Nam P. 
Published: October 2021

AbstractCrowdsourcing is an emerging tool for collaboration and innovation platforms. Recently, crowdsourcing platforms have become a vital tool for firms to generate new ideas, especially large firms such as Dell, Microsoft, and Starbucks, Crowdsourcing provides firms with multiple advantages, notably, rapid solutions, cost savings, and a variety of novel ideas that represent the diversity inherent within a crowd. The literature on crowdsourcing is limited to empirical evidence of the advantage of crowdsourcing for businesses as an innovation strategy. In this study, Starbucks’ crowdsourcing platform, Ideas Starbucks, is examined, with three objectives: first, to determine crowdsourcing participants’ perception of the company by crowdsourcing participants when generating ideas on the platform. The second objective is to map users into a community structure to identify those more likely to produce ideas; the most promising users are grouped into the communities more likely to generate the best ideas. The third is to study the relationship between the users’ ideas’ sentiment scores and the frequency of discussions among crowdsourcing users. The results indicate that sentiment and emotion scores can be used to visualize the social interaction narrative over time. They also suggest that the fast greedy algorithm is the one best suited for community structure with a modularity on agreeable ideas of 0.53 and 8 significant communities using sentiment scores as edge weights. For disagreeable ideas, the modularity is 0.47 with 8 significant communities without edge weights. There is also a statistically significant quadratic relationship between the sentiments scores and the number of conversations between users.
Shared decision making for the initiation and continuation of dialysis: a proposal from the Japanese Society for Dialysis Therapy
Authors: Okada Kazuyoshi , Tsuchiya Ken , Sakai Ken , Kuragano Takahiro , Uchida Akiko , Tsuruya Kazuhiko , Tomo Tadashi , Hamada Chieko , Fukagawa Masafumi , Kawaguchi Yoshindo , Watanabe Yuzo , Aita Kaoruko , Ogawa Yoshitatsu , Uchino Junji , Okada Hirokazu , Koda Yutaka , Komatsu Yasuhiro , Sato Hisamitsu , Hattori Motoshi , Baba Toru , Matsumura Mamiko , Miura Hisayuki , Minakuchi Jun , Nakamoto Hidetomo ,   Committee for Updating the Proposal for Shared Decision Making on Initiation and Continuation of Dialysis, General Affairs Committee of the Japanese Society for Dialysis Therapy, Okada Kazuyoshi , Tsuchiya Ken , Sakai Ken , Kuragano Takahiro , Uchida Akiko , Tsuruya Kazuhiko , Tomo Tadashi , Hamada Chieko , Fukagawa Masafumi , Kawaguchi Yoshindo , Watanabe Yuzo , Aita Kaoruko , Ogawa Yoshitatsu , Uchino Junji , Okada Hirokazu , Koda Yutaka , Komatsu Yasuhiro , Sato Hisamitsu , Hattori Motoshi , Baba Toru , Matsumura Mamiko , Miura Hisayuki , Minakuchi Jun , Nakamoto Hidetomo 
Published: October 2021

Abstract
Background
In Japan, forgoing life-sustaining treatment to respect the will of patients at the terminal stage is not stipulated by law. According to the Guidelines for the Decision-Making Process in Terminal-Stage Healthcare published by the Ministry of Health, Labor and Welfare in 2007, the Japanese Society for Dialysis Therapy (JSDT) developed a proposal that was limited to patients at the terminal stage and did not explicitly cover patients with dementia. This proposal for the shared decision-making process regarding the initiation and continuation of maintenance hemodialysis was published in 2014.

Methods and results
In response to changes in social conditions, the JSDT revised the proposal in 2020 to provide guidance for the process by which the healthcare team can provide the best healthcare management and care with respect to the patient's will through advance care planning and shared decision making. For all patients with end-stage kidney disease, including those at the nonterminal stage and those with dementia, the decision-making process includes conservative kidney management.

Conclusions
The proposal is based on consensus rather than evidence-based clinical practice guidelines. The healthcare team is therefore not guaranteed to be legally exempt if the patient dies after the policies in the proposal are implemented and must respond appropriately at the discretion of each institution.
Business confidence as a strong tracker of future growth: is it driven by economic policy uncertainty and oil price shocks in the OECD countries?
Authors: Adekoya Oluwasegun B. , Oliyide Johnson A. 
Published: October 2021

AbstractBusiness confidence matters for future growth as it relies on opinion surveys of developments in production activities, orders and stocks of finished products. Is it then affected by economic policy uncertainty and oil price asymmetries in the OECD countries? With limited evidence in the literature, we adopt the Augmented Mean Group (AMG) estimator following the evidence of cross-sectional dependence, non-stationarity and cointegration in the panel series. The full sample results show that business confidence is negatively affected by economic policy uncertainty and oil price. Moreover, the role of asymmetries cannot be neglected as both positive and negative oil price changes show different impacts on business confidence. The sub-sample results further reveal that the impacts of economic policy uncertainty and oil price on business confidence are higher in the Eurozone countries than in their non-Eurozone counterparts. We believe this is due to the central economic coordination and higher net-oil dependence and import status of the Eurozone countries.
Patterns of Prostate-Specific Antigen Testing and Prostate Biopsies During the COVID-19 Pandemic
Authors: Kaufman Harvey W. , Chen Zhen , Niles Justin K. , Radcliff Jeff , Fesko Yuri 
Published: October 2021

PURPOSEThis study examined changes in prostate disease screening (prostatic-specific antigen [PSA] testing), prostate biopsy testing, and prostate cancer diagnoses during the COVID-19 pandemic through December 2020.MATERIALS AND METHODSThis analysis included test results from men ≥ 40 years, without prior International Classification of Diseases-10 record of prostate cancer since January 2016, who received PSA or prostate biopsy testing at Quest Diagnostics during January 2018-December 2020. Monthly trends were evaluated for three periods: prepandemic (January 2018-February 2020), early-pandemic (March-May 2020), and late-pandemic (June-December 2020).RESULTSMeeting inclusion criteria were 16,365,833 PSA and 48,819 prostate biopsy results. The average monthly number of PSA tests declined from 465,187 prepandemic to 295,786 early-pandemic (36.4% decrease; P = .01) before rebounding to 483,374 (3.9% increase; P = .23) late-pandemic. The monthly average number of PSA results ≥ 50 ng/mL (23,356; 0.14% of all PSA results) dipped from 659 prepandemic to 506 early-pandemic (23.2% decrease; P = .02) and rebounded to 674 late-pandemic (2.3% increase; P = .65). The average monthly number of prostate biopsy results decreased from 1,453 prepandemic to 903 early-pandemic (37.9% decrease; P = .01) before rebounding to 1,190 late-pandemic (18.1% decrease; P = .01). The average monthly number for Gleason score ≥ 8 (6,241; 12.8% of all prostate biopsies) declined from 182 prepandemic to 130 early-pandemic (28.6% decrease; P = .02) and decreased to 161 late-pandemic (11.5% decrease; P = .02).CONCLUSIONThe findings suggest that a substantial number of prostate screening opportunities and cancer diagnoses have been missed. Efforts are needed to bring such patients back for screening and diagnostic testing and to restore appropriate care for non–COVID-19–related medical conditions.
Developmental mechanisms of sex differences: from cells to organisms
Authors: Mank Judith E. , Rideout Elizabeth J. 
Published: October 2021

ABSTRACT
Male-female differences in many developmental mechanisms lead to the formation of two morphologically and physiologically distinct sexes. Although this is expected for traits with prominent differences between the sexes, such as the gonads, sex-specific processes also contribute to traits without obvious male-female differences, such as the intestine. Here, we review sex differences in developmental mechanisms that operate at several levels of biological complexity – molecular, cellular, organ and organismal – and discuss how these differences influence organ formation, function and whole-body physiology. Together, the examples we highlight show that one simple way to gain a more accurate and comprehensive understanding of animal development is to include both sexes.
Bivalves rapidly repair shells damaged by fatigue and bolster strength
Authors: Crane R. L. , Diaz Reyes J. L. , Denny M. W. 
Published: October 2021

ABSTRACT
Hard external armors have to defend against a lifetime of threats yet are traditionally understood by their ability to withstand a single attack. Survival of bivalve mollusks thus can depend on the ability to repair shell damage between encounters. We studied the capacity for repair in the intertidal mussel Mytilus californianus by compressing live mussels for 15 cycles at ∼79% of their predicted strength (critically fracturing 46% of shells), then allowing the survivors 0, 1, 2 or 4 weeks to repair. Immediately after fatigue loading, mussel shells were 20% weaker than control shells that had not experienced repetitive loading. However, mussels restored full shell strength within 1 week, and after 4 weeks shells that had experienced greater fatiguing forces were stronger than those repetitively loaded at lower forces. Microscopy supported the hypothesis that crack propagation is a mechanism of fatigue-caused weakening. However, the mechanism of repair was only partially explained, as epifluorescence microscopy of calcein staining for shell deposition showed that only half of the mussels that experienced repetitive loading had initiated direct repair via shell growth around fractures. Our findings document repair weeks to months faster than demonstrated in other mollusks. This rapid repair may be important for the mussels’ success contending with predatory and environmental threats in the harsh environment of wave-swept rocky coasts, allowing them to address non-critical but weakening damage and to initiate plastic changes to shell strength. We highlight the significant insight gained by studying biological armors not as static structures but, instead, as dynamic systems that accumulate, repair and respond to damage.
Flight altitude dynamics of migrating European nightjars across regions and seasons
Authors: Norevik Gabriel , Åkesson Susanne , Andersson Arne , Bäckman Johan , Hedenström Anders 
Published: October 2021

ABSTRACT
Avian migrants may fly at a range of altitudes, but usually concentrate near strata where a combination of flight conditions is favourable. The aerial environment can have a large impact on the performance of the migrant and is usually highly dynamic, making it beneficial for a bird to regularly check the flight conditions at alternative altitudes. We recorded the migrations between northern Europe and sub-Saharan Africa of European nightjars Caprimulgus europaeus to explore their altitudinal space use during spring and autumn flights and to test whether their climbs and descents were performed according to predictions from flight mechanical theory. Spring migration across all regions was associated with more exploratory vertical flights involving major climbs, a higher degree of vertical displacement within flights, and less time spent in level flight, although flight altitude per se was only higher during the Sahara crossing. The nightjars commonly operated at ascent rates below the theoretical maximum, and periods of descent were commonly undertaken by active flight, and rarely by gliding flight, which has been assumed to be a cheaper locomotion mode during descents. The surprisingly frequent shifts in flight altitude further suggest that nightjars can perform vertical displacements at a relatively low cost, which is expected if the birds can allocate potential energy gained during climbs to thrust forward movement during descents. The results should inspire future studies on the potential costs associated with frequent altitude changes and their trade-offs against anticipated flight condition improvements for aerial migrants.
How Market Power Affects Dynamic Pricing: Evidence from Inventory Fluctuations at Car Dealerships
Authors: Israeli Ayelet , Scott-Morton Fiona , Silva-Risso Jorge , Zettelmeyer Florian 
Published: October 2021

This paper investigates empirically the effect of market power on dynamic pricing in the presence of inventories. Our setting is the auto retail industry; we analyze how automotive dealerships adjust prices to inventory levels under varying degrees of market power. We first establish that inventory fluctuations create scarcity rents for cars that are in short supply. We then show that dealers’ ability to adjust prices in response to inventory depends on their market power, that is, the quantity of substitute inventory in their selling area. Specifically, we show that the slope of the price–inventory relationship (higher inventory lowers prices) is significantly steeper when dealers find themselves in a situation of high rather than low market power. A dealership with high market power moving from a situation of inventory shortage to a median inventory level lowers transaction prices by about 0.57% ceteris paribus, corresponding to 32.5% of dealers’ average per-vehicle profit margin or $145.6 on the average car. Conversely, when competition is more intense, moving from inventory shortage to a median inventory level lowers transaction prices by about 0.35% ceteris paribus, corresponding to 20.2% of dealers’ average per-vehicle profit margin or $90.9. To our knowledge, we are the first to empirically show that market power affects firms’ ability to dynamically price. This paper was accepted by Juanjuan Zhang, marketing.
Morpho-agronomy performance, seed nutrition content, and Aphis craccivora resistance of cowpea (Vigna unguiculata) genotypes
Authors: Sas Muhamad Ghazi Agam , Wahyu Yudiwanti , SYUKUR MUHAMAD , Hidayat Purnama 
Published: October 2021

Abstract. Sas MGA, Wahyu Y, Syukur M, Hidayat P. 2021. Morpho-agronomy performance, seed nutrition content, and Aphis craccivora resistance of cowpea (Vigna unguiculata) genotypes. Biodiversitas 22: 4320-4326. Cowpea (Vigna unguiculata subsp. unguiculata) is an agricultural commodity that can be a source of vegetable protein and replace the need for soy as a food ingredient. The wide adaptability under sub-optimum conditions placed cowpeas as the choice to be developed. This study aimed to evaluate the cowpea genotype’s agronomic performance and resistance to Aphis craccivora to be proposed as superior genotypes. Observations were made on the morpho-agronomic characters, including the color of the young pods and dry seeds, the number of pods, the productivity of fresh pods and dried seeds, and the nutrition content. The resistance to Aphis craccivora was evaluated using a no-choice test whole plant for the resistance and tolerance evaluation. This study showed that the productivity of young pods (4.86-15.13 tons ha-1), dry seed productivity (0.83-2.71 tons ha-1). The protein content differed significantly among the 20 genotypes ranging from 19.24% to 24.45%. Aphid infestation significantly inhibited plant growth compared with non-infested plants. Infestation of Aphis craccivora decreased the dry weight of the plant by about 20% to 70%. Based on the aphid population, the 20 genotypes were classified into medium-high to very high aphid damage intensity.
Antibacterial activity of leaves, flowers, and fruits extract of Etlingera elatior from Nagan Raya District, Indonesia against Escherichia coli and Staphylococcus aureus
Authors: ERNILASARI ERNILASARI , WALIL KAMALLIANSYAH , FITMAWATI FITMAWATI , ROSLIM DEWI INDRIYANI , ZUMAIDAR ZUMAIDAR , SAUDAH SAUDAH , RAYHANNISA RAYHANNISA 
Published: October 2021

Abstract. Ernilasari, Walil K, Fitmawati, Roslim DI, Zumaidar, Saudah, Rayhannisa. 2021. Antibacterial activity of leaves, flowers, and fruits extract of Etlingera elatior from Nagan Raya District, Indonesia against Escherichia coli and Staphylococcus aureus. Biodiversitas 22: 4457-4464. Etlingera elatior is a medicinal plant that has been used by people in Indonesia, especially Acehnese people. Based on its secondary metabolites, E. elatior can be used as antibacterial agents against Gram-positive and Gram-negative. However, to determine the antibacterial activity of E. elatior, the parts of E. elatior that have been used are leaves, flowers, and fruits. This study was aimed to determine the best concentration of ethanol extract of leaves, flowers, and fruits of E. elatior as an inhibitor against Escherichia coli and Staphylococcus aureus. The extract was made by the maceration method with 70% ethanol as a solvent. Antibacterial activity test was carried out by the diffusion agar method using concentrations of 0.5%, 1%, 1.5% and 2%. The results showed that the fruit extract of E. elatior has antibacterial activity with an effective inhibitory zone at a concentration of 2% is 8.4 mm (E. coli) and 2.4 mm (S. aureus). Meanwhile, antibacterial activity the extract of leaves and flowers against E. elatior cannot determine yet. Identification of leaves, flowers and fruits extract of E. elatior using GC-MS (gas chromatography-mass spectroscopy) showed 56 compounds were detected.