bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparing Future Human Resources in Language Learning: EFL Student Teachers’ Voices’ Academic Stressors
Authors: Hidayat Marzul , Putri Dery Mulya , Fortunasari Fortunasari , Fridiyanto Fridiyanto , Habibi Akhmad , Mukminin Amirul 
Published: December 2021

Preparing good and skillful human resources in language learning is avoidable, particularly for the country like Indonesia which is still a developing one. The intent of this qualitative study in the case study tradition was used to explore what the academic factors that made EFL student teachers as future human resources feel stressed in English language learning at one public university in Jambi, Sumatra, Indonesia. We adopted a qualitative case study approach. Using a convenience case strategy, we interviewed EFL student teachers. The primary data for our study were collected through the face-to-face interviews. The interviews were conducted in English, audio-taped, and directly transcribed verbatim. The interviews data were analyzed through reading line by line all the transcriptions to find major themes. We found eight salient and interweaved themes led EFL student teachers as future human resources feel stressed in English language learning including (1) internal and external factors of choosing English as a major,(2) pleasure and displeasure feeling in studying English in university, (3) positive and negative responses to the lecturers in studying English, (4) positive and negative influences of friends in English major, (5) feeling about academic activities (credits, assignments, subjects and examinations) (6) feeling about discussion or presentations, (7) the most pressure or stress issue during the learning processes, and (8) dealing with the stressors. The findings of this study shed light on our understanding of the academic factors that made EFL student teachers as future human resources feel stressed in English language learning.
Livestock Frontiers
Authors: Schneider Mindi , Coghe Samuël 
Published: December 2021

The word livestock itself suggests the reduction of animals as living things to animals as economic goods. Disaggregating the term into its component parts—live and stock—also suggest the difficulty of rendering things that are alive into things that are stocked, especially on large or predicable scales. The be alive is biological; living things breathe, eat, defecate, move, sleep, grow, reproduce, connect with others, get sick, die. To be stock, on the other hand, is economic; stocks are things held and exchanged. In capitalist relations specifically, livestock (and livestock parts) are owned, quantified, rationalized, commodified, specialized, simplified, contracted, accumulated, speculated upon, traded, sold.

Ongoing attempts to make living things into stocks, or commodities, are rife with contradictions and impossibilities. Fundamentally, biological bodies are barriers to accumulation. The unruliness of living stocks—including their biological needs, the time they take to grow and mature, their propensities toward genetic diversity, and their vulnerabilities in environments where diversity is strictly denied—make them particularly difficult to standardize and simplify for the market. Just as Karl Polanyi (1944) unveiled the fiction of land, labor, and money as commodities, animals must join this list.
Application of IAC Yokohama system for breast cytology – The experience at a tertiary care hospital
Authors: Krishna  Kanth GVRN , Sunitha Aka , Chandra Sharath 
Published: December 2021

Breast malignancies are one of the commonest malignancies in Indian women. Increasing urbanization is attributed to raise of breast cancers and have surpassed cervix cancer in recent times and are now ranked top in some metros. FNA is used as an important diagnostic tool as a part of triple assessment. The application of the IAC Yokohama system in breast cytology improves the reporting and also allows the calculation of risk of malignancy (ROM). The main aim of the study is to; 1. Apply the IAC Yokohama system for the diagnostic; 2. assessment and subsequent categorization of FNA samples and correlate them with histopathology examination (HPE); 3. calculate ROM; 4. Calculate p-value.A total of 305 samples received were diagnosed and classified according to the IAC Yokohama system. The study was conducted over a period of 2 yrs retrospectively from June 2019 to May 2021. For the 305 FNA samples received, HPE correlation was made and statistical parameters, ROM , p-value were calculated.305 FNA samples were obtained and categorized according to the IAC Yokohama system. They were categorized and the percentage of incidence noted as 1. Insufficient - 6.89%, 2.Benign - 72.46%, 3.Atypical probably benign - 3.28%, 4. Suspicious - 3.28%, 5. Malignant - 14.09%. ROM was also calculated. The distribution of cases in percentage as per categories are: category 1 – 0%, category 2 - 2%, category 3 – 0%, category 4- , 42.86% category 5- 100%. For 305 FNA samples reported 95 cases received for HPE and subsequently cyto – histopathological correlation was made and statistical parameters were calculated. Compiled statistics showed sensitivity of 100%, specificity of 93.54%, NPV of 100%, PPV of 89.19% and diagnostic accuracy at 95.78%. The p-value for the present study is 0.0001 which is very significant.Application of the IAC Yokohama system of reporting breast cytopathology helps in better categorization of FNA samples and it improves the efficacy of cytopathologist. It gives better clarity to the clinicians in the management of the patient and can reduce unnecessary surgeries.
Evaluation of renal biopsies in various kidney diseases with reference to staining
Authors: Pandey Kaushlendra Kumar , Delphine Silvia CR Wilma , Pandey Aparna , Agarwal Asha 
Published: December 2021

Renal diseases of different origin and nature may produce essentially similar disturbances of renal functions and may have clinical similarities and hence there was a need to classify renal diseases more scientifically. The basic approach was to correlate clinical signs and symptoms with histological changes in the tissue, using both simple and special staining techniques so as to reach to a definitive diagnosis.The present study was conducted on renal biopsy referred to pathology department. Criteria for successful biopsy were as follows-Adequate biopsy sample size, correct processing of specimen, informed interpretation and issue of an accurate report. A total of 29 renal biopsies were examined. In minimal change disease, only in 4 patients the glomerulus was sclerosed. Membranous glomerulonephritis comprised of the maximum number of cases (9/30). Total of 3 cases of renal biopsies revealed amyloidosis. Focal amyloid deposits with deposits either near the hilum or perivascular areas were found in 33.3% of cases, while extensive amyloid deposits were found in 33.3% of the cases.It is necessary to determine both the type of renal disease and the cause of the primary disorder in order to make the diagnosis and various staining techniques play a very helpful role. The likelihood that the biopsy specimen accurately reflects the type and severity of the underlying disease is directly related to both the diffuseness of the disease process and the amount of tissue examined.
Nodular Fasciitis of the breast – An uncommon benign reactive proliferative lesion
Authors: Jagtap Sunil V , Nagar Vaidehi , Bhosale S J , Nagar Dharmesh , Jagtap Swati S 
Published: December 2021

Nodular fasciitis is rarely reported in breast. It is benign reactive proliferative lesion of fibroblast. A 65 year old female presented to surgical department for left breast mass since 2 months duration, rapidly enlarging without any regional lymphadenopathy. Mammography showed hyperdensity masses with irregular margin. On FNAC reported as benign spindle cell lesion. Left sided two breast masses measuring 4 x 3.3 x 2.5cm and 2.0 x 1.6 x 0.5cm were excised and on histopathology reported as Nodular Fasciitis of left breast. We are presenting this extremely rare case of nodular fasciitis of breast for its clinical, radiological and histopathological findings.
The Demography, Clinical Characteristics, and White Blood Analysis of Leprosy Reactions in Multibacillary Leprosy: A Retrospective Study
Authors: Tanojo Natalia , Damayanti Damayanti , Utomo Budi , Ervianti Evy , Murtiastutik Dwi , Prakoeswa Cita Rosita Sigit , Listiawan M. Yulianto 
Published: December 2021

Background: Leprosy is a neglected tropical disease caused by chronic granulomatous infection of Mycobacterium leprae. Indonesia ranks third in new case findings, with 84% of the case being multibacillary (MB) leprosy. MB leprosy cases have a higher risk of leprosy reactions and physical disabilities that decrease quality of life. Purpose: To determine the demographic, clinical characteristics, and white blood analysis of newly diagnosed MB leprosy patients, especially concerning leprosy reactions. Methods: This is a descriptive retrospective study with a cross-sectional design that describe the following data: domicile, gender, age, treatment status, disabilities, body mass index (BMI); bacterial index (BI), morphological index (MI), white blood cell (WBC) and differential counts, and thrombocyte count. Result: This study included 176 adult MB cases, predominantly male aged 20–39 years old with average BMI, lived in Surabaya with negative history of multi-drug therapy, disability, BI, nor MI. The grade 2 disability (G2D) percentage in this study setting than in Indonesia (10.7% vs. 6.43%). The WBCs, especially neutrophil count, was higher in T2R group. Monocyte and lymphocyte counts were relatively similar. There was an increase in thrombocyte count in leprosy reaction groups. Conclusion: MB leprosy in the endemic area, which is more commonly found in productive-aged male, displayed higher G2D than global Indonesia population. Thus denotes the importance of active case findings. The difference in blood analysis characteristics between MB leprosy with and without reactions may serve as the foundation for future study.
Prognosis of Aggressive Treatment of Primary Hepatic Angiosarcoma: A Single-Center Experience
Authors: Chen Yang-Yuan , Chen Yung-Fang , Chen Chih-Hsuan , Yang Horng Ren 
Published: December 2021

Background and Aims: Of all primary liver tumors, primary hepatic angiosarcoma (PHA) is a rare and aggressive malignant vascular tumor. The standard therapeutic care for hepatic angiosarcoma remains unclear.
This study compared the survival outcomes of aggressive treatment (resection and liver transplant) and nonaggressive treatment (chemotherapy, transarterial chemoembolization [TACE], and conservative treatments) for patients with PHA and analyzed the prognostic factors influencing survival.
Materials and Methods: Data of patients diagnosed as having PHA at our facility were retrospectively reviewed. The primary outcome was survival time. The secondary outcome was calculated baseline characteristics.
Results: We included a total of 19 patients, who were divided into 2 treatment groups: aggressive (8 patients had undergone resection or transplants) and nonaggressive (11 patients had undergone TACE, chemotherapy, or conservative treatment). The mean survival time was 233.1 ± 189.7 days in the aggressive treatment group and 146.5 ± 115.8 days in the nonaggressive treatment group. A Kaplan-Meier plot revealed no significant difference in survival time between the 2 treatment groups (P = .3256).
Conclusions: The survival time of patients receiving aggressive treatment was longer than that of those receiving nonaggressive treatment. The long term survival time in some selective cases of aggressive treatment will be achieved. Thought a difference was not significant between the groups. Because the number of patients was limited, more cases are required to confirm these findings.
Metal Hypersensitivity and Complex Regional Pain Syndrome After Bilateral Total Knee Arthroplasty
Authors: Sagoo Navraj S. , Sharma Ruhi , Alaraj Sami , Sharma Ishaan K. , Bruntz Adam J. , Bajaj Gurpreet S. 
Published: December 2021

Case:
A 38-year-old man underwent bilateral total knee arthroplasty (TKA) and subsequently developed diffuse pain, swelling, and an eczematous rash that spread throughout his body. Despite various pharmacological regimens, sympathetic blocks, aggressive physical therapy, and further knee revisions, the patient's symptoms progressed over a period of 2 years. An in vitro memory lymphocyte immuno-stimulation assay test demonstrated reactivity to nickel after which bilateral revision TKAs with oxidized zirconium alloys resulted in symptomatic improvement.

Conclusion:
Metal hypersensitivity should be considered after the exclusion of infection; however, the concurrent development of complex regional pain syndrome may mask the clinical presentation.
Strengthening Maternal Death Surveillance Systems for Evidence-Based Decision Making in Sub-Saharan Africa: The Case of the Center Region in Cameroon
Authors: Bongajum Yenban Anastasia , Foumane Pascal , Moussi Charlotte , Vogue Noel , Banseka Hycinth , Nwobegahay Jujlius , Baye Martina 
Published: December 2021

Background: The article seeks to document the experience of implementing Maternal Death Surveillance and Response (MDSR) in the Center Region of Cameroon. The paper raises awareness on the need for implementing MDSR, shares progress and lessons learned and reflects on the implications for public health practice.
Methods: A desk research involving the collection and analysis of secondary data using tables with specific themes in excel, following the review of existing resources at the Regional Delegation of Public Health-Center from the year 2016 to 2019.
Results: The findings depict the existence of MDSR policies and sub-regional committees. Although, the number of regional maternal death notifications increased from 19 to 188 deaths between 2016 and 2019, the implementation of death review recommendations was only estimated at 10% in 2019. While 66% of deaths occurred in Yaoundé, 72% of these were deaths reported to have occurred in tertiary institutions out of which 75% were attributed to late referrals. Hemorrhage constituted 70/144 (48.6%) of the known direct causes of death. Maternal death related co-factors such as the use of partograph during labor had a high non-response rate (84%) and represents a weakness in the data set.
Conclusion and Global Health Implications: Across the board, stakeholder engagement towards MDSR was increased through continuous awareness-raising, dissemination of surveillance tools, the institutionalization of the District Health Information Software (DHIS 2) and the “No Name No Blame” policy. However, the reporting and investigation of deaths for informed decisions remain a daunting challenge. For a resource-scarce setting with limited access to blood banks, the application of life-saving cost-effective interventions such as the use of partographs and the institution of a functional referral system among health units is likely to curb the occurrence of deaths from hemorrhage and other underlying causes. The success of these will require a robust strengthening of the health system.

Copyright © 2021 Bongajum, et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
One-Year Analysis of the Refractive Stability, Axial Elongation and Related Factors in a High Myopia Population after Implantable Collamer Lens Implantation
Authors: Chen Xun , Chen Zhi , Miao Huamao , Wang Xuanqi , Wang Xiaoying , Zhou Xingtao 
Published: December 2021

Abstract
Purpose: To investigate the refractive stability, axial length changes and their related factors in a high myopia population after Implantable Collamer Lens (ICL) implantation.Methods: This prospective study included 116 eyes of 116 patients divided into several groups based on the spherical equivalent refractive error (SE)—SE > -6D, -12 ≤ SE < -6D and SE < -12D groups—and axial length (AL)—AL < 28mm and AL ≥ 28mm groups. The uncorrected and corrected distance visual acuity, refraction, axial length and intraocular pressure were followed for 1 year.Results: SE changed from -11.53 ± 5.25D preoperatively to -0.33 ± 0.70D at 1 week, and further changed to -0.48 ± 0.77D at 1 year after ICL implantation, with average progression being -0.15 ± 0.37D from 1 week to 1 year after surgery. Axial length changed from 27.95 ± 2.33mm preoperatively to 27.98 ± 2.36mm 1 year after surgery, with an average axial elongation of 0.03 ± 0.12mm. The mean axial elongation rate was 0.05mm/year in the SE < -12D group, being significantly faster than the other SE groups (P < 0.05); it was 0.06mm/year in the AL ≥ 28mm group, being significantly faster than the AL < 28mm group (P < 0.05).Conclusion: Patients with high myopia and long axial length showed a continuous myopic progression and axial elongation at an adult age after ICL surgery, especially those with myopia higher than -12.0D and AL longer than 28.00mm.
Kiss1/Gpr54 Prevents Bone Loss through Src Dephosphorylation
by Dusp18 in Osteoclasts
Authors: Li Zhenxi , Yang Xinghai , Jiao Jian , Wu Zhipeng , Wu Zhixiang , Xu Shengzhao , Li Wenjun , Ma Guoli , Wu Pengfei , Qian Ming , Wei Haifeng , Zhao Jian , Chen Yihua , Zhang Han-kun , Cheng Yiyun , Siwko Stefan , Lian Gewei , Inuzuka Hiroyuki , Wei Wenyi , Song Gaojie , Luo Jian , Liu Mingyao , Xiao Jianru 
Published: December 2021

Abstract
Osteoclasts were over-activated as we age, which leads to bone loss. Src-deficient mice lead to only one phenotype -severe osteopetrosis due to functional defect in osteoclasts, indicating that Src function is essential in osteoclasts. G-protein-coupled receptors (GPCR) have been targets for ∼35% of approved drugs. However, how Src kinase activity is negatively regulated by GPCRs remains largely elusive. Herein we report that Src is dephosphorylated at Tyr 416 by Dusp18 upon GPR54 activation by its natural ligand Kp-10. Mechanically, both active Src and the Dusp18 phosphatase are recruited by GPR54 through the proline/arginine-rich motif (PR motif) in the C terminus, which is dependent on the Gαq signal pathway. As such, Kiss1, Gpr54, Dusp18 knockout mice all exhibit osteoclast hyperactivation and bone loss. Accordingly, Kp-10 abrogated bone loss by suppressing osteoclasts activity in vivo. Therefore, Kiss1/Gpr54 is a promising therapeutic strategy governing bone resorption through Src dephosphorylation by Dusp18.
Inositol Hexakisphosphate Primes Syndapin I/PACSIN 1 Activation In Endocytosis
Authors: Shi Yue , Zhao Kaixuan , Yang Guang , Yu Jia , Li Yuxin , Kessels Michael M. , Yu Lina , Qualmann Britta , Berggren Per-Olof , Yang Shao-Nian 
Published: December 2021

Abstract
Endocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not fully understood. We now show that syndapin I/PACSIN 1 is expressed in pancreatic β cells and that its knockdown abrogates β cell endocytosis leading to disturbed plasma membrane protein homeostasis, as exemplified by an elevated density of L-type Ca2+ channels. Intriguingly, inositol hexakisphosphate (InsP6) activates casein kinase 2 (CK2) phosphorylating syndapin I/PACSIN 1, promoting interactions between syndapin I/PACSIN 1 and neural Wiskott-Aldrich syndrome protein (N-WASP) thereby driving β cell endocytosis. Dominant-negative interference with endogenous syndapin I/PACSIN 1 protein complexes, by overexpression of the syndapin I/PACSIN 1 SH3 domain, decreases InsP6-stimulated endocytosis. InsP6 thus promotes syndapin I/PACSIN 1 priming by CK2-dependent phosphorylation, which endows the syndapin I/PACSIN 1 SH3 domain with the capability to interact with the endocytic machinery and thereby initiate endocytosis, as exemplified in β cells.
5-Fluorouracil And Curcumin With Pectin Coating As a Treatment Regimen For Titanium Dioxide Induced Colon Cancer Model
Authors: Karthika Chenmala , Sureshkumar Raman , Sajini Deepak Vasudevan Vasudevan , Ash Gulam Md , Rahman Md. Habibur 
Published: December 2021

Abstract
Objective: Induction of colorectal cancer in Wister rats using titanium dioxide and dimethylhydrazine and treatment using the physical conjugate of 5-Fluorouracil and Curcumin, with a synergistic approach.Methods: Compatibility studies are evaluated by using FT-IR,Vero cell lines, and HCT-116 cell lines are used for evaluating the synergistic approach. This followed by induction using titanium dioxide and dimethylhydrazine in Wister rats and treatment using 5-Fluorouracil and Curcumin with pectin coating. Result: The samples were found to be compatible. The synergistic effect was obtained at 1:1, 1:2, 1:4, and 2:1 ratio, where 1:4 ratio shows a CI50 value of 0.896, selected further for the animal studies when studied in HCT 116 cell lines and found to be safe with Vero cell lines. Colorectal cancer was shown to be induced within 70 days of administration of titanium dioxide and dimethylhydrazine.1:4 ratio of 5-Fluorouracil and Curcumin (50:200) shows effective for the treatment of colorectal cancer within 28 days, proven using histopathology report, bodyweight analysis, and hematological reports.Conclusion: 5-Fluorouracil and curcumin (1:4) ratio works with a synergistic approach and was proven effective for the treatment of colorectal cancer induced bythe titanium dioxide and dimethylhydrazine.
Cost-effectiveness of a Transdiagnostic Psychotherapy Program for Youth With Common Mental Health Problems
Authors: Wolf Rasmus Trap , Jeppesen Pia , Pedersen Mette Maria Agner , Puggaard Louise Berg , Thastum Mikael , Bilenberg Niels , Thomsen Per Hove , Silverman Wendy K. , Plessen Kerstin Jessica , Neumer Simon-Peter , Correll Christoph U. , Pagsberg Anne Katrine , Gyrd-Hansen Dorte 
Published: December 2021

Abstract
Objectives: Our objective was to evaluate the cost-effectiveness of the transdiagnostic psychotherapy program Mind My Mind (MMM) for youth with common mental health problems using a cost-utility analysis (CUA) framework and data from a randomized controlled trial. Furthermore, we analyzed the impact of choice of informant with respect to both quality-of-life reporting and preference weights on the Incremental Cost Effectiveness Ratio (ICER). Methods: A total of 396 school-aged youth took part in the 6-month trial. CUAs were carried out for the trial-period and for four one-year extrapolation scenarios. Costs were based on a combination of budget and self-reported costs. Youths and parents were asked to report on the youth’s quality-of-life three times during the trial using the Child Health Utility 9D (CHU9D). Parental-reported CHU9D was used in the base case together with preference weights of a youth population. Analyses using self-reported CHU9D and preference weights of an adult population were also carried out. Results: The analysis of the trial period resulted in an ICER of €170,465. The analyses of the one-year scenarios resulted in ICERs between €23,653 and €50,480. The ICER increased by 24% and 71% compared to the base case when using self-reported CHU9D and adult preference weights, respectively. Conclusion: The MMM intervention has the potential to be cost-effective, but the ICER is dependent on the duration of the treatment effects. Results varied significantly with the choice of respondent and the choice of preference weights indicating that both factors should be considered when assessing CUA involving youth.