bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended Erosive Oral Lichen Planus Treated with a very Low-Level Laser Therapy: A Case Report
Authors: Mameli Antonello , Murgia Martina Salvatorina , Orrù Germano , Casu Cinzia 
Published: January 2021

Background:
Oral lichen planus is a chronic idiopathic inflammatory disease that affects the skin and mucous membrane and involves about 1-2% of the population. The management of this pathology aims to control symptoms. Clinically, it can appear as a plaque, in reticular form, or an erythematous/atrophic form. The treatment options include different classes of drugs and non-drug therapies such as a laser. In addition, most drug treatments include numerous side effects.

Objective:
The aim of this work is to evaluate the clinical effectiveness of a particular type of very Low-Level-Laser Therapy for the management of an erosive oral lichen planus case.

Methods:
An extensive form of erosive Oral Lichen Planus was treated using a Low-Level Laser Therapy with a 660 nm diode laser. The treatment was performed once per week for two sessions of five minutes each. Different outcome variables were examined: the size of lesions, evolution of pain symptoms, and presence of side effects and stability of the therapeutic results in the follow-up period.

Results:
After a week, the lesion appeared more homogenous, and the erythematous areas underwent a reduction with a simultaneous decrease in symptoms. After two weeks, the lesion seemed completely healed with the disappearance of pain. The follow-up continued for the other four months, and no relapse was reported. No adverse effects were observed during the study.

Conclusion:
This study suggests that Low-Level Laser Therapy with very low power parameters could be a safe and successful treatment for extended oral erosive lichen planus lesions.
Anti-obesity Effects of Some Plant Extracts in Rats Fed with High-Fat
Diet
Authors: Al-Azhary Diaa B. , Amin Hanan M. , Kotb Eman M. 
Published: January 2021

Background and Aim:
Obesity has reached epidemic proportions around the world, resulting
in severe health effects and financial costs, which have led to prompt actions and the advancement
of phytochemistry technologies as new treatment techniques. This study aimed to assess
and compare the anti-obesity, antioxidant, and anti-inflammatory effects of some common and
safe doses of natural products like bitter orange, flax seeds, and ginger in adult male albino rats fed
a high-fat diet.

Methods:
Fifty adult male albino rats were divided into five groups (n=10): a negative control
group that received a balanced normal diet, a positive control group that received a high-fat diet
(HFD) for eight weeks, and other 3 groups were fed HFD for eight weeks receiving daily 20
mg/kg/day of bitter orange fruit aqueous extract (standardized at 10% p- synephrine) or 250 mg/kg/-
day of flax seeds ethanol extract or 200 mg/kg/day of ginger rhizomes ethanol extract for the last 4
weeks. All rats were sacrificed at the end of the study to obtain blood, liver, and kidney samples
for biochemical and histopathological analyses.

Results:
The herbal extracts reduced body weight, lipid profile, inflammatory markers alpha-fetoprotein
(AFP) and C reactive protein (CRP), malondialdehyde (MDA), and liver enzymes, all of
which had been increased by the HFD. Furthermore, treatment with herbal extracts resulted in a significant
reduction and improvement of the proliferated inflammatory infiltration, congested veins,
and fatty vacuolated vesicles induced by HFD in liver and kidney tissues. Bitter orange exhibited
the strongest anti-obesity effects, while flaxseed and ginger showed the strongest antioxidant and
anti-inflammatory effects in response to the HFD.

Conclusion:
In obese rats, the use of these herbal extracts displayed a variety of possible protective
and therapeutic effects. As a result, they are recommended for obese people, and further research is
needed to determine the effects of a combination of various biochemical components found in these
plant extracts on obesity and related disorders.
A Flash on Cell Therapy Strategies in Clinical Trials against SARS-CoV-2
Authors: Sadat Seyed Mehdi , Larijani Mona Sadat , Ramezani Amitis , Aghasadeghi Mohammad Reza 
Published: January 2021

Background:
Since December 2019, an outbreak of a novel coronavirus infection has
been reported, drawing immediate attention from the World Health Organization. SARS-CoV-2, as
the cause of COVID-19 with extra potency of transmission, has led to global concern. Currently,
more than a thousand clinical trials have focused on achieving a protective or preventive approach
against the virus, among which cell-based therapies seem to be significantly applicable.

Objective:
We aimed to summarize cell-based therapy against COVID-19 and compare the applicable
methods and possible outcomes.

Methods:
The current clinical trials based on cell-based therapies are summarized according to the
cell sorting applications. The possible approaches, advantages, and opinions are discussed.

Results and Conclusion:
Cell-based therapy has already brought some hope. It needs to meet the
following features: 1) The long-term protection data after treatment must be provided by stem cell
investigators. 2) A design of multivalent antigens based on immunoinformatic prediction is suggested
to engineer T-cell and dendritic cell-based therapies in order to deliver the most immunogenic
conserved epitopes. 3) According to the sophisticated procedure, the preparation of the cells must
be supported by authorities in order to decrease the cost and the time of the whole process.
A Russian Funeral Film: The Funeral of Anastasia Vial'tseva
Authors: Domagala Jakob , Speegle Shawn 
Published: January 2021

Vol. 2, No. 2 (2020)
This issue of SourceLab presents the 1913 funeral film of Russian singer Anastasia Vial'tseva.
This publication is part of the digital documentary edition series SourceLab, based at the University of Illinois at Urbana-Champaign. Our Editorial Board conducts rigorous peer-review of every edition.
APLIKASI PEMESANAN MAKANAN UNTUK MENINGKATKAN PENJUALAN BAGI UMKM BERBASIS ANDROID
Authors: M.Cs Pujianto 
Published: January 2021

<p>Usaha Mikro, Kecil dan Menengah (UMKM) merupakan salah satu penggerak roda perekonomian di Indonesia. UMKM menjadi fokus pemerintah Indonesia karena UMKM memiliki kontribusi sebesar 60,3% dari total produk domestik bruto (PDB) Indonesia. Selain itu, UMKM menyerap 97% dari total tenaga kerja dan 99% dari total lapangan kerja. Untuk meningkatkan daya saing bagi UMKM diperlukan digitalisasi penjulan dalam melakukan proses bisnisnya. Rumusan dalam peneliian ini adalah bagaimana membuat aplikasi pemesanan makanan berbasis Android bagi UMKM. Tujuan dari penelitian ini adalah membuat aplikasi pemesanan makanan bagi UMKM berbasis Android. Metode penelitia ini menggunakan metode research and development, sedangkan pengembangan sistem menggunakan waterfall model. Hasil dari penelitian ini adalah sebuah aplikasi pemesanan makanan yang dapat digunakan oleh pengguna dalam memesan makanan yang diinginkan sesuai dengan menu yang ditampilkan. Proses pemesanan makanan sangat simpel dan sistem akan melakukan validasi sebelum makanan dipesan ke pelaku UMKM. Sebelum sistem digunakan dilakukan pengujian terhadap aplikasi terkait fitur-fitur yang ada pada aplikasi. Dengan adanya aplikasi ini diharapkan dapat meningkatkan penjualan bagi UMKM yang telah bergabung sehingga dapat meningkatkan perekonomian.</p>
Antecedents of Individuals’ Concerns Regarding Hospital Hygiene and Surgery Postponement During the COVID-19 Pandemic: Cross-sectional, Web-Based Survey Study
Authors: Ostermann Thomas , Gampe Julia , Röer Jan Philipp , Radtke Theda 
Published: January 2021

Background
The COVID-19 pandemic poses a major challenge to people’s everyday lives. In the context of hospitalization, the pandemic is expected to have a strong influence on affective reactions and preventive behaviors. Research is needed to develop evidence-driven strategies for coping with the challenges of the pandemic. Therefore, this survey study investigates the effects that personality traits, risk-taking behaviors, and anxiety have on medical service–related affective reactions and anticipated behaviors during the COVID-19 pandemic.

Objective
The aim of this study was to identify key factors that are associated with individuals’ concerns about hygiene in hospitals and the postponement of surgeries.

Methods
We conducted a cross-sectional, web-based survey of 929 residents in Germany (women: 792/929, 85.3%; age: mean 35.2 years, SD 12.9 years). Hypotheses were tested by conducting a saturated path analysis.

Results
We found that anxiety had a direct effect on people’s concerns about safety (β=−.12, 95% CI −.20 to −.05) and hygiene in hospitals (β=.16, 95% CI .08 to .23). Risk-taking behaviors and personality traits were not associated with concerns about safety and hygiene in hospitals or anticipated behaviors.

Conclusions
Our findings suggest that distinct interventions and information campaigns are not necessary for individuals with different personality traits or different levels of risk-taking behavior. However, we recommend that health care workers should carefully address anxiety when interacting with patients.
BROWNIES FROM MANGROVE FRUIT FLOUR: THE USE OF VARIATION OF FLOURS AS AN ALTERNATIVE TO HIGH FOOD NUTRITION
Authors: Sumartini Sumartini , Harahap Kurnia Sada , Mujiyanti Apri 
Published: January 2021

Brownies is a popular high-calorie snack. In this studied, brownies were processed from several types of flour, namely pedada fruit (Sonneratia caseolaris) flour, api-api (Avicennia officinalis) flour, red bean flour, and modified cassava flour with nutritional value and health benefits compared to the commercial ones (from wheat flour). The purpose of this studied was to determine the used of a variety of superior flours as raw material for making brownies in terms of nutritional value and leveled of preference. The experimental design used a completely randomized design (CRD) with test parameters including the leveled of preference, caloric value, fiber, and proximate composition. The results of the studied were tested for variance using spss version 22 software with a 95% confidence interval. The results showed that the best results were brownies made from pedada fruit flour because they had higher fiber and lowered calories with test scores for calorie content, crude fiber, air content, fat content, protein content, ash content, carbohydrate content respectively. 401. 87 kcal each; 16.49%; 18.32%; 21.7%; 4.03%; 1.44%; and 54.64%.
OLIGO-GLUCOMANNAN PRODUCTION FROM PORANG (Amorphophallus oncophyllus) GLUCOMANNAN BY ENZYMATIC HYDROLYSIS USING β-MANNANASE
Authors: Anggela Anggela , Setyaningsih Widiastuti , Wichienchot Santad , Harmayani Eni 
Published: January 2021

Porang (Amorphophallus oncophyllus) is an indigenous tuber of Indonesia that rich in glucomannan. An alternative approach to produce porang oligo-glucomannan (POG) as prebiotic from porang glucomannan (PGM) was made by enzymatic hydrolysis using β-mannanase. This study aimed to produce POG under optimal conditions by controlled enzymatic hydrolysis process. The PGM flour contained 96.12% of indigestible carbohydrates. The optimum condition of enzymatic hydrolysis producing the highest reducing sugar was as follows: temperature 37°C, pH 5.5, a ratio of enzyme to the substrate (E/S) 1:1000, and reaction time 4 h. HPLC analysis confirmed that 99.45% of the resulting POG consisted of oligosaccharides with a degree of polymerization (DP) 3. Hence, the PGM utilized in this study has been proven as a potential substrate for POG production. Additionally, the resulting POG was considered as a functional ingredient due to has prebiotic potential.
BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ENTRECTINIB IN RAT PLASMA BY LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY
Authors: KE PRAVALLIKA , RANI A PRAMEELA , KUMAR M RATNA 
Published: January 2021

Objective: The objective of the study was to develop and validate the bioanalytical liquid chromatography–mass spectrometry (LCMS/MS) method for the estimation of entrectinib in bulk and pharmaceutical drugs in rat plasma.
Methods: Chromatographic separation of entrectinib with D4-entrectinib as internal standard (IS) was achieved using Waters Alliance high-performance liquid chromatography system, quaternary gradient pump of e2695, using Luna, 250×4.6 mm, 5 μm column and the mobile phase containing 0.1% formic acid and acetonitrile (ACN) within the ratio of 70:30% v/v. The flow was 1.0 ml/min; detection was carried out by absorption at 294 nm using a photodiode array detector at ambient temperature.
Results: The peak of entrectinib was eluted at retention times of 5.225 min. The multiple reaction monitoring was 560.6/475.1 (m/z) for entrectinib and 580.6/496.3 (m/z) for IS entrectinib (D4). The linearity range was 1–20 ng/ml with a regression coefficient of 0.999. % relative standard deviation of peak areas of all measurements always <2.0.
Conclusion: The method was successfully validated and it had been found to be within limits for accuracy, precision, and linearity and it is stable under analytical conditions used.
GLYCATED HEMOGLOBIN LEVELS IN METABOLIC SYNDROME PATIENTS
Authors: MANDAL GUNJAN KUMAR , BHATT SANJAY 
Published: January 2021

Objectives: Metabolic syndrome (MetS) is a cluster of several metabolic disorders including hyperglycemia, reduced high-density lipoprotein cholesterol, and raised triglyceride level in serum, hypertension, and abdominal obesity. Glycated hemoglobin (HbA1c) is used as one of the diagnostic criteria for diabetes and diagnostic tool for MetS.
Methods: The present study was conducted at Prasad Institute of Medical Sciences. The study includes 150 patients with MetS as a case and 150 healthy volunteers as a control. MetS was diagnosed according to National Cholesterol Education Program’s Adult Treatment Panel III criteria. HbA1c was assayed in various components of MetS.
Results: It was found that HbA1c was significantly higher in MetS patients when compared to control group.
Conclusion: Our study suggests that HbA1c might be used as a diagnostic criterion for MetS. Therefore, proper glycemic control should be maintained by maintaining HbA1c level <6.5% to prevent from diabetes and MetS.
HOSPITAL-BASED CLINICAL STUDY ON PREVALENCE OF TPO ANTIBODIES IN ASSOCIATION TO AUTOIMMUNE THYROID DISEASES IN TERTIARY CARE HOSPITAL
Authors: SINGH JASJOT , PRABHAKAR PRANAV KUMAR , NEUPANE NURAKANT 
Published: January 2021

Objective: Autoimmune thyroid disease is one of the organs specific autoimmune disorders. The onset is much more common in women than in men. Worldwide, 2–4% of women and only 1% of men have affected and the rate increases with age. Thyroperoxidase (TPO) antibodies (Abs) level helps to diagnose autoimmune thyroid disease along with levels of thyroid stimulating hormone (TSH), Free Tri-iodotyrosine (Free T3), and Free Thyroxin(Free T4) and it helps in differentiation between subclinical and overt thyroidism. The core objective of clinical study was to evaluate prevalence of anti-TPO Abs in association to autoimmune thyroid disease in a tertiary care hospital – Punjab.
Methods: A cross-sectional study of random patient (n=200 patients) at a tertiary care hospital, Mohall – Punjab was carried out. All the patients fall in the age group 12–89 years. The parameters, which were used for the diagnosis of autoimmune thyroid disease, were anti-TPO level, Free T3 level, and Free T4 level. The patients were divided in different group on the basis of their age, gender, and their clinical conditions. The level of TPO Abs, TSH, Free T3, and Free T4 was noted for each patient. Electrochemiluminescence immunoassay method was used for determination of TPO Abs and other thyroid parameters. After a period of 16 weeks, subjects from different groups had great difference in their anti-TPO values in the autoimmune thyroid disease.
Results: TPO Abs positive is one of the most common associated with hypothyroidism which was 36.5%, among them 20.5% suffered from subclinical hypothyroidism, whereas other remaining suffered from clinical hypothyroidism, clinical hyperthyroidism, and other autoimmune disease.
Conclusion: TPO Abs level helps to diagnose autoimmune thyroid disease, along with this the level of TSH, Free T3, and Free T4 helps in differentiation between subclinical and overt thyroidism.
KNOWLEDGE, ATTITUDE, PRACTICE, AND PERCEPTION TOWARDS COVID-19 IN NORTH EASTERN STATES OF INDIA: AN ONLINE CROSS SECTIONAL STUDY
Authors: SRIVASTAVA AMIT , BALA RENU , SHIL RATAN CHANDRA , SHAW PRABIN KUMAR , KARSO LIYI , BHAUMIK HIMADRI , TAMANG SANTOSH KUMAR , BHATTACHARJEE BAIDURJYA , NATH TAPAN , CHAKMA ABHIJIT , SINHA PRASENJIT 
Published: January 2021

Objective: The study aimed to assess knowledge, attitude, practices, and perception (KAP) toward COVID-19 among the population of eight North Eastern (NE) states of India.
Methods: A cross-sectional study from June 30 to July 13, 2020 was carried out through a self-reported, structured questionnaire that was circulated online to participants of age group of 18 years or above. Convenient sampling was used to recruit respondents for the study.
Results: The study received responses from 8309 participants. Key findings revealed that most respondents had good knowledge of preventive measures and common symptoms of COVID-19. The majority of the respondents showed a good attitude and adopted preventive practices. The mean score of knowledge was 7.137, attitude was 16.132, practice was 9.379, and perception was 13.583. The scores of four KAP categories significantly differed across most of the demographic variables (p<0.001). The majority of people took homoeopathic medicine as prophylaxis for immune booster.
Conclusion: The study highlights that the focus on behavioral change communication in all the NE states could be strengthened, especially in rural areas. Advocacy based on the comprehensive list of symptoms for COVID-19 may also be bolstered. There is scope for strategically promoting knowledge, immunity boosting, and self-care practices suggested in the AYUSH systems of medicine.
RELATION OF MEDICATION ADHERENCE TO THE INCIDENCE OF COMPLICATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS
Authors: DARMADA PUTU DEWINTA , CATUR WULANDARI DEWI 
Published: January 2021

Objective: The prevalence of diabetes mellitus continues to increase worldwide, followed by the incidence of complications, which ends up causing morbidity and mortality in patients. There were many factors related to the incidence of complications in diabetes mellitus. Patient’s adherence to their medication is considered to have an impact on the complications in diabetic patients.
Methods: The study was conducted on 68 patients with a cross-sectional method with consecutive sampling. Statistical analysis was done using the Chi-square and Fisher’s exact test. p<0.05 was considered statistically significant. Patients were interviewed using a demographic data questionnaire and medication adherence rating scale – 5 (MARS-5). Other data and diagnosis of complications were collected through medical records. The epidemiological analysis was carried out using the prevalence ratio.
Results: There were 47 (69.1%) patients with type 2 diabetes mellitus (T2DM) hospitalized due to complications, and 56 (82.4%) patients have poor adherence to treatment. There was a significant relationship between treatment adherence and the incidence of complications in diabetes mellitus patients with p = 0.001 and it was found that there was a risk of 3.14 times in patients who have poor adherence to be hospitalized due to complications.
Conclusion: Treatment adherence affects the incidence of complications in patients with T2DM.
Protein and Peptide Based Drug Delivery- A Review
Authors: P.V.Kamala Kumari  , M.Yamini  , Y.Srinivasa Rao  , S. Satya Lakshmi  
Published: January 2021

Biologics include vaccines, recombinant proteins, genes, synthetic tissues and viruses, which have emerged from molecular and cellular biology, with respect to unmet clinical needs and expanding indications. Hence it is important at this stage to outline the essential events that have led to the current level of interest in protein and peptide drug delivery systems. Polymers consisting of amino acids that are covalently linked by peptide bonds are known as Proteins and inturn peptides are small proteins composed of few dozen amino acids. Due to large molecular sizes of the proteins ranging from thousands to several millions atomic masses sizes; absorption through the epithelial barriers in the gastrointestinal tract is low. Moreover, proteins are rapidly degraded by digestive enzymes. As the bioavailability by oral route is poor they can be administered by other routes mainly by parenteral (IV, SC, IM) injections. The biological activity of proteins is strongly dependent on their molecular structure i.e 10 structure; the amino acid sequence, which ultimately dictates the non-covalent interactions and the 20i.e alpha helices and beta helices; the periodic spatial arrangement of the polypeptide chain backbone and 30; the 3-dimensional conformation of the whole molecule, including the positions of all amino acid side chains. Some proteins may consist of multiple peptide chains grouped together by non-covalent intermolecular interactions. The arrangement of these subunits relative to each other constitutes the 40structure. An alteration at any level of molecular structure leads to a change or loss of biological activity. The present review focuses on the development of various routes of drug administration, formulation as well as stability aspects of protein and peptide drug delivery system.
O planejamento na Curadoria Digital
Authors: Siebra Sandra de Albuquerque 
Published: January 2021

Reflete sobre o planejamento no contexto da curadoria digital. Esta é uma pesquisa descritiva e qualitativa, que faz uso da pesquisa bibliográficae documental. Como resultados, foram definidas seis dimensões que devem ser exploradas no planejamento e os elementos dentro delas,independente do tipo de objeto digital a ser curado, foram elas: infraestrutura, recursos financeiros, recursos humanos, ações relacionadascom preservação digital, questões legais e éticas e questões relacionadas ao acesso e uso dos objetos digitais. Foram indicados documentosque devem ser produzidos durante o planejamento para orientar as equipes do projeto, como o Plano de Preservação Digital e, também, foiressaltada a importância da participação da comunidade alvo do projeto de curadoria nesta etapa. Por fim, foi verificado que as descriçõessobre planejamento, na maioria dos modelos de curadoria digital é ainda sucinta, técnica e superficial e podem não dar apoio suficientepara a realização do planejamento da curadoria por parte das instituições/organizações. Conclui-se que é necessário que os profissionaisda informação estejam aptos a elaborar materiais para suprir essa lacuna e para orientar a implementação de projetos de curadoria digital.
Palavras-Chave: Planejamento para Curadoria Digital. Modelos de ciclos de vida. Curadoria Digital. Etapa de Planejamento. PreservaçãoDigital.