bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung ultrasound in ruling out COVID-19 pneumonia in the ED: a multicentre prospective sensitivity study
Authors: Di Gioia Carmine Cristiano , Artusi Nicola , Xotta Giovanni , Bonsano Marco , Sisto Ugo Giulio , Tecchiolli Marzia , Orso Daniele , Cominotto Franco , Amore Giulia , Meduri Stefano , Copetti Roberto 
Published: December 2021

PurposeEarly diagnosis of COVID-19 has a crucial role in confining the spread among the population. Lung ultrasound (LUS) was included in the diagnostic pathway for its high sensitivity, low costs, non-invasiveness and safety. We aimed to test the sensitivity of LUS to rule out COVID-19 pneumonia (COVIDp) in a population of patients with suggestive symptoms.MethodsMulticentre prospective observational study in three EDs in Northeastern Italy during the first COVID-19 outbreak. A convenience sample of 235 patients admitted to the ED for symptoms suggestive COVIDp (fever, cough or shortness of breath) from 17 March 2020 to 26 April 2020 was enrolled. All patients underwent a sequential assessment involving: clinical examination, LUS, CXR and arterial blood gas. The index test under investigation was a standardised protocol of LUS compared with a pragmatic composite reference standard constituted by: clinical gestalt, real-time PCR test, radiological and blood gas results. Of the 235 enrolled patients, 90 were diagnosed with COVIDp according to the reference standard.ResultsAmong the patients with suspected COVIDp, the prevalence of SARS-CoV-2 was 38.3%. The sensitivity of LUS for diagnosing COVIDp was 85.6% (95% CI 76.6% to 92.1%); the specificity was 91.7% (95% CI 86.0% to 95.7%). The positive predictive value and the negative predictive value were 86.5% (95%CI 78.8% to 91.7%) and 91.1% (95% CI 86.1% to 94.4%) respectively. The diagnostic accuracy of LUS for COVIDp was 89.4% (95% CI 84.7% to 93.0%). The positive likelihood ratio was 10.3 (95% CI 6.0 to 17.9), and the negative likelihood ratio was 0.16 (95% CI 0.1 to 0.3).ConclusionIn a population with high SARS-CoV-2 prevalence, LUS has a high sensitivity (and negative predictive value) enough to rule out COVIDp in patients with suggestive symptoms. The role of LUS in diagnosing patients with COVIDp is perhaps even more promising. Nevertheless, further research with adequately powered studies is needed.Trial registration numberNCT04370275.
Predictors of health-related quality of life following injury in childhood and adolescence: a pooled analysis
Authors: Dipnall Joanna F , Rivara Frederick P , Lyons Ronan A , Ameratunga Shanthi , Brussoni Mariana , Lecky Fiona E , Bradley Clare , Beck Ben , Lyons Jane , Schneeberg Amy , Harrison James E , Gabbe Belinda J 
Published: December 2021

BackgroundInjury is a leading contributor to the global disease burden in children and places children at risk for adverse and lasting impacts on their health-related quality of life (HRQoL) and development. This study aimed to identify key predictors of HRQoL following injury in childhood and adolescence.MethodsData from 2259 injury survivors (<18 years when injured) were pooled from four longitudinal cohort studies (Australia, Canada, UK, USA) from the paediatric Validating Injury Burden Estimates Study (VIBES-Junior). Outcomes were the Paediatric Quality of Life Inventory (PedsQL) total, physical, psychosocial functioning scores at 1, 3–4, 6, 12, 24 months postinjury.ResultsMean PedsQL total score increased with higher socioeconomic status and decreased with increasing age. It was lower for transport-related incidents, ≥1 comorbidities, intentional injuries, spinal cord injury, vertebral column fracture, moderate/severe traumatic brain injury and fracture of patella/tibia/fibula/ankle. Mean PedsQL physical score was lower for females, fracture of femur, fracture of pelvis and burns. Mean PedsQL psychosocial score was lower for asphyxiation/non-fatal submersion and muscle/tendon/dislocation injuries.ConclusionsPostinjury HRQoL was associated with survivors’ socioeconomic status, intent, mechanism of injury and comorbidity status. Patterns of physical and psychosocial functioning postinjury differed according to sex and nature of injury sustained. The findings improve understanding of the long-term individual and societal impacts of injury in the early part of life and guide the prioritisation of prevention efforts, inform health and social service planning to help reduce injury burden, and help guide future Global Burden of Disease estimates.
Recovery after stroke: the severely impaired are a distinct group
Authors: Bonkhoff Anna K , Hope Tom , Bzdok Danilo , Guggisberg Adrian G , Hawe Rachel L , Dukelow Sean P , Chollet François , Lin David J , Grefkes Christian , Bowman Howard 
Published: December 2021

IntroductionStroke causes different levels of impairment and the degree of recovery varies greatly between patients. The majority of recovery studies are biased towards patients with mild-to-moderate impairments, challenging a unified recovery process framework. Our aim was to develop a statistical framework to analyse recovery patterns in patients with severe and non-severe initial impairment and concurrently investigate whether they recovered differently.MethodsWe designed a Bayesian hierarchical model to estimate 3–6 months upper limb Fugl-Meyer (FM) scores after stroke. When focusing on the explanation of recovery patterns, we addressed confounds affecting previous recovery studies and considered patients with FM-initial scores <45 only. We systematically explored different FM-breakpoints between severe/non-severe patients (FM-initial=5–30). In model comparisons, we evaluated whether impairment-level-specific recovery patterns indeed existed. Finally, we estimated the out-of-sample prediction performance for patients across the entire initial impairment range.ResultsRecovery data was assembled from eight patient cohorts (n=489). Data were best modelled by incorporating two subgroups (breakpoint: FM-initial=10). Both subgroups recovered a comparable constant amount, but with different proportional components: severely affected patients recovered more the smaller their impairment, while non-severely affected patients recovered more the larger their initial impairment. Prediction of 3–6 months outcomes could be done with an R2=63.5% (95% CI=51.4% to 75.5%).ConclusionsOur work highlights the benefit of simultaneously modelling recovery of severely-to-non-severely impaired patients and demonstrates both shared and distinct recovery patterns. Our findings provide evidence that the severe/non-severe subdivision in recovery modelling is not an artefact of previous confounds. The presented out-of-sample prediction performance may serve as benchmark to evaluate promising biomarkers of stroke recovery.
Frailty, lifestyle, genetics and dementia risk
Authors: Ward David D , Ranson Janice M , Wallace Lindsay M K , Llewellyn David J , Rockwood Kenneth 
Published: December 2021

ObjectiveTo optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics.MethodsWe explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data.ResultsThe analytical sample had a mean age of 64.1 years at baseline (SD=2.9) and 53% were women. Incident dementia was detected in 1762 participants (median follow-up time=8.0 years). High frailty was associated with increased dementia risk independently of genetic risk (HR 3.68, 95% CI 3.11 to 4.35). Frailty mediated 44% of the relationship between healthy lifestyle behaviours and dementia risk (indirect effect HR 0.95, 95% CI 0.95 to 0.96). Participants at high genetic risk and with high frailty had 5.8 times greater risk of incident dementia compared with those at low genetic risk and with low frailty (HR 5.81, 95% CI 4.01 to 8.42). Higher genetic risk was most influential in those with low frailty (HR 1.31, 95% CI 1.22 to 1.40) but not influential in those with high frailty (HR 1.09, 95% CI 0.92 to 1.28).ConclusionFrailty is strongly associated with dementia risk and affects the risk attributable to genetic factors. Frailty should be considered an important modifiable risk factor for dementia and a target for dementia prevention strategies, even among people at high genetic risk.
Medical students’ and junior doctors’ leadership and teamwork skills improved after involvement with Simulation via Instant Messaging-Birmingham Advance (SIMBA)
Authors: Ng Cai Ying , Allison Isabel , Ooi Emma , Davitadze Meri , Melson Eka , Kempegowda Punith 
Published: December 2021

BackgroundLeadership and teamwork skills are essential components of medical education. Simulation via Instant Messaging-Birmingham Advance (SIMBA) is an innovative simulation-based learning tool mainly delivered by medical students and junior doctors. This study aimed to investigate the effect of SIMBA on leadership and teamwork skills of medical students and junior doctors during COVID-19.MethodsAll medical students and junior doctors involved in the delivery of SIMBA were invited to complete the Leadership Trait Questionnaire (LTQ) and Teamwork Skills Questionnaire (TSQ) assessing their views pre-SIMBA and post-SIMBA involvement. The changes in scores were analysed using the Wilcoxon signed-rank test. Open-ended questions were reviewed in an inductive thematic analysis.ResultsA total of 33 SIMBA team members completed both questionnaires. There was improvement in all traits measured in the LTQ and TSQ, significant in 9/14 LTQ traits, and all 6 TSQ traits (p<0.05). ‘Decision making’ had the highest improvement (p<0.0001). Response to open-ended questions reported positive effects on personal development, medical professionalism, communication skills and medical/clinical knowledge.ConclusionsSIMBA is an effective model to inculcate leadership and teamwork skills among medical students and junior doctors. Prospective studies are underway to assess long-term impact.
Variation in age of primiparity in mountain goats (Oreamnos americanus) estimated from horn growth increments
Authors: Rice Chad , Larue Benjamin , Festa-Bianchet Marco 
Published: December 2021

Variation in age of primiparity is important for population dynamics and wildlife management because it can affect population growth. Using a novel technique based on the trade-off between annual horn growth and reproduction, we estimated the age of primiparity for 2274 female mountain goats (Oreamnos americanus (Blainville, 1816)) harvested across British Columbia, Canada, from 1976 to 2019. We then investigated spatio-temporal variation in the probability that harvested females were primiparous when aged 3, 4, or 5 years and older using Bayesian ordinal regressions. We found that the probability of primiparity at 3 years decreased over time in nearly all mountain ranges. In the Coastal Mountain range, however, the probability of primiparity at age 3 significantly increased. These results suggest that the large coastal populations of mountain goats could be more resilient to harvest than other populations in British Columbia, which may be experiencing environmental effects promoting later primiparity. Models predicting age of primiparity from annual growth measures are a valuable tool for wildlife management and could help conservation of many species.
Contrasting transform and passive margin subsidence history and heat flow evolution: insights from 3D thermo-mechanical modelling
Authors: Balázs Attila , Gerya Taras , May Dave , Tari Gábor 
Published: December 2021

Abstract
Transform and passive margins developed during the continental rifting and opening of oceanic basins are fundamental elements of plate tectonics. It has been suggested that inherited structures, plate divergence velocities and surface processes exert a first-order control on the topographic and bathymetric evolution and thermal history of these margins and related sedimentary basins. Their complex spatial-temporal dynamics have remained controversial. Here, we conducted 3D magmatic-thermo-mechanical numerical experiments coupled with surface processes modelling to simulate the dynamics of continental rifting, continental transform fault zone formation as well as persistent oceanic transform faulting and zero-offset oceanic fracture zones development. Numerical modelling results allow to explain the first-order observations from passive and transform margins, such as diachronous rifting, heat flow rise and cooling in individual depocentres as well as contrasting basin tectonics of extensional and transtensional origin. In addition, the models reproduce the rise of both marginal ridges and transform marginal plateaus, and their interaction with erosion and sedimentation. Comparison of model results with observations from natural examples yields new insights into the tectono-sedimentary and thermal evolution of several key passive and transform continental margins worldwide.
Reliability Estimation of Inverse Lomax Distribution Using Extreme Ranked Set Sampling
Authors: Al-Omari Amer Ibrahim , Hassan Amal S. , Alotaibi Naif , Shrahili Mansour , Nagy Heba F. 
Published: December 2021

In survival analysis, the two-parameter inverse Lomax distribution is an important lifetime distribution. In this study, the estimation of

R
=
P

Y
<
X

is investigated when the stress and strength random variables are independent inverse Lomax distribution. Using the maximum likelihood approach, we obtain the

R

estimator via simple random sample (SRS), ranked set sampling (RSS), and extreme ranked set sampling (ERSS) methods. Four different estimators are developed under the ERSS framework. Two estimators are obtained when both strength and stress populations have the same set size. The two other estimators are obtained when both strength and stress distributions have dissimilar set sizes. Through a simulation experiment, the suggested estimates are compared to the corresponding under SRS. Also, the reliability estimates via ERSS method are compared to those under RSS scheme. It is found that the reliability estimate based on RSS and ERSS schemes is more efficient than the equivalent using SRS based on the same number of measured units. The reliability estimates based on RSS scheme are more appropriate than the others in most situations. For small even set size, the reliability estimate via ERSS scheme is more efficient than those under RSS and SRS. However, in a few cases, reliability estimates via ERSS method are more accurate than using RSS and SRS schemes.
Oral HPV Infection among Indigenous Australians; Incidence, Persistence, and Clearance at 12-Month Follow-up
Authors: Sethi Sneha , Ju Xiangqun , Antonsson Annika , Canfell Karen , Smith Megan A. , Garvey Gail , Hedges Joanne , Jamieson Lisa 
Published: December 2021

Abstract

Background:
Persistent oral human papillomavirus (HPV) infection is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC). Indigenous Australians have a higher rate of OPSCC than non-Indigenous Australians. Risk factors for oral HPV persistence among Indigenous Australians are poorly understood.

Methods:
Participants provided information on sociodemographic characteristics, health-related behaviors including tobacco and alcohol use, and sexual history. Participants additionally provided saliva samples for microbial genotyping. Negative log binomial regression models were used to evaluate associations of sociodemographic, health behavior, and sexual behavior indicators on incident, persistent, and cleared oral HPV infection at 12-month follow-up. Estimates were quantified as rate ratios (RR).

Results:
Of the 1,011 participants recruited at baseline, 911 provided saliva samples that were β-globin positive (a DNA integrity check), with 321 (35.3%) testing positive for any oral HPV infection. At 12-month follow up, saliva samples were obtained from 743 of the original 1,011 participants (73.5%). Among the 584 participants who provided β-globin–positive saliva samples at baseline and 12-month follow-up, 24 (42.6%) had no oral HPV infection at both time points, 130 (22.2%) had new (incident) oral HPV infection at 12 months, 130 (22.2%) had persistent oral HPV infection (i.e., present at both baseline and 12 months), and 75 (12.8%) had oral HPV infection clearance from baseline to 12 months. Age of first giving oral sex and unsafe (unprotected) oral sexual behaviors were significantly associated with incidence; rural location of residence and ever received oral sex were significantly associated with persistence; and, rural location of residence and ever received oral sex were significantly associated with clearance of oral HPV infection.

Conclusions:
The incidence of oral HPV infection at both baseline and 12-month follow-up was high. Factors associated with persistence and clearance of oral HPV infections included location of residence and unsafe oral sexual behaviors.

Impact:
There are currently no studies available which have assessed oral HPV infection incidence, persistence, and clearance amongst Indigenous populations in Australia or even at a global level. The study has been able to identify risk factors associated with potential malignant changes in the oropharynx among Indigenous Australians.
Procedural Risk in Congenital Cardiac Catheterization (PREDIC
3
T)
Authors: Quinn Brian P. , Yeh Mary , Gauvreau Kimberlee , Ali Fatima , Balzer David , Barry Oliver , Batlivala Sarosh , Berman Darren , Foerster Susan , Goldstein Bryan , Hainstock Michael , Holzer Ralf , Janssen Dana , O’Byrne Michael L. , Shirley Lauren , Trucco Sara , Whiteside Wendy , Bergersen Lisa 
Published: December 2021

Background
Advancements in the field, including novel procedures and multiple interventions, require an updated approach to accurately assess patient risk. This study aims to modernize patient hemodynamic and procedural risk classification through the creation of risk assessment tools to be used in congenital cardiac catheterization.

Methods and Results

Data were collected for all cases performed at sites participating in the C3PO (Congenital Cardiac Catheterization Project on Outcomes) multicenter registry. Between January 2014 and December 2017, 23 119 cases were recorded in 13 participating institutions, of which 88% of patients were <18 years of age and 25% <1 year of age; a high‐severity adverse event occurred in 1193 (5.2%). Case types were defined by procedure(s) performed and grouped on the basis of association with the outcome, high‐severity adverse event. Thirty‐four unique case types were determined and stratified into 6 risk categories. Six hemodynamic indicator variables were empirically assessed, and a novel hemodynamic vulnerability score was determined by the frequency of high‐severity adverse events. In a multivariable model, case‐type risk category (odds ratios for category: 0=0.46, 1=1.00, 2=1.40, 3=2.68, 4=3.64, and 5=5.25; all
P
≤0.005) and hemodynamic vulnerability score (odds ratio for score: 0=1.00, 1=1.27, 2=1.89, and ≥3=2.03; all
P
≤0.006) remained independent predictors of patient risk.

Conclusions
These case‐type risk categories and the weighted hemodynamic vulnerability score both serve as independent predictors of patient risk for high‐severity adverse events. This contemporary procedure‐type risk metric and weighted hemodynamic vulnerability score will improve our understanding of patient and procedural outcomes.
Abstract 1122‐000012: Study Design and Selection Criteria of a Large Core Thrombectomy Trial —— ANGEL‐ASPECT
Authors: Huo Xiaochuan , Huo Xiaochuan , Ren Zeguang , Ren Zeguang , Ma Gaoting , Ma Gaoting , Tong Xu , Tong Xu , Zhang Xuelei , Zhang Xuelei , Vitor Pereira , Pereira Vitor Mendes , Miao Zhongrong , Miao Zhongrong 
Published: December 2021

Introduction
: The ANGEL‐ASPECT trial (NCT 04551664) is an ongoing, multicenter, randomized controlled trial (RCT) currently being conducted in China. The goal of ANGEL‐ASPECT’s is to include the maximum patients with a true large core for whom EVT is not recommended under current guidelines with level 1 evidence. By enrolling patients with ASPECTS <6, expanding the window to 24h from stroke onset (beyond the windows in DAWN and DEFUSE3), and defining large core volume as >70 cc, ANGEL‐ASPECT maximizes the inclusion of patients with true large cores. What’s more, intracranial atherosclerotic disease (ICAD) is common in the Asian population while most of the previous trials have been performed in the Western world where ICAD is less prevalent.

Methods
: We reviewed the merits of ANGEL‐ASPECT’s design and suggest that it be included in the discussion of patient selection criteria in large core trials.

Results
: The primary goal of our trial is to determine whether EVT will benefit or harm AIS patients with LVO and a “large core” infarct. The inclusion criteria for ANGEL‐ASPECT are:

1. If ASPECTS is 3–5 and presentation is within 24 hours of onset, patients are enrolled without obtaining CTP.
2. If ASPECTS is >5 and presentation is beyond 6 hours of onset, only patients with relative cerebral blood flow (rCBF) of < 30% by CTP or apparent diffusion coefficient (ADC) of < 620 on MRI and estimated core volume of 70–100 cc are enrolled.
3. If ASPECTS is <3, only patients with rCBF < 30% or ADC on MRI < 620 and estimated core volume of 70–100 cc are enrolled. Patients are enrolled under a pre‐specified protocol. Each randomized patient is qualified by two core lab members who are available at all hours to calculate ASPECTS and infarct core volume using specialized, RAPID software.

Conclusions
: We believe that defining core volume using CTP can compensate for the inconsistencies of ASPECTS if we exclude patients with onset within six hours and core volume of 50–70 cc since these patients have already been shown to benefit from EVT in multiple RCTs. We believe that this decision captures more patients with true large core volumes for the trial. The ANGEL‐ASPECT inclusion criteria also eliminate the second group of “good ASPECTS + unfavorable CTP” . The sample size of our trial is calculated based on studies excluding these populations. The power of the trial was maintained for the relatively consistent large core volume patient population.
Deep Learning for Text Style Transfer: A Survey
Authors: Jin Di , Jin Zhijing , Hu Zhiting , Vechtomova Olga , Mihalcea Rada 
Published: December 2021

AbstractText style transfer is an important task in natural language generation, which aims to control certain attributes in the generated text, such as politeness, emotion, humor, and many others. It has a long history in the field of natural language processing, and recently has re-gained significant attention thanks to the promising performance brought by deep neural models. In this article, we present a systematic survey of the research on neural text style transfer, spanning over 100 representative articles since the first neural text style transfer work in 2017. We discuss the task formulation, existing datasets and subtasks, evaluation, as well as the rich methodologies in the presence of parallel and non-parallel data. We also provide discussions on a variety of important topics regarding the future development of this task.1
The Impact of Short-Term Employment for Low-Income Youth: Experimental Evidence from the Philippines
Authors: Beam Emily A. , Quimbo Stella 
Published: December 2021

Abstract
We use a randomized field experiment to test the causal impact of short-term work experience on employment and school enrollment among disadvantaged, in-school youth in the Philippines. This experience leads to a 4.4 percentage point (79%) increase in employment eight to twelve months later. Although we find no aggregate increase in enrollment, we also do not find that the employment gains push youth out of school. Our results are most consistent with work experience serving as a signal of unobservable applicant quality, and these findings highlight the role of temporary work as a stepping stone to employment for low-income youth.