bluuebunny/crossref_metadata_2025_split huggingface dataset:
When firms embrace science: University alliances and firm drug development pipeline
Authors: Slavova Kremena 
Published: December 2021

AbstractTraditional model of closed innovation has been challenged, and firms in biomedical sciences are teaming up with universities to advance scientific discoveries and publish their research results in scholarly journals. This study examines the contingent nature of the relationship between university‐industry alliances and a firm's follow‐on contribution to open science in the context of therapeutic biotechnology. It integrates insights from organizational learning theory and sociology of science to explore boundary conditions of the efficacy of the organizational learning mechanism across the realms of business and academic science. Specifically, our contention is that, under certain circumstances, for‐profit firms are likely to learn from their university alliance partners how to harness the dynamics of the open system of scientific knowledge exchange and embrace open science. Our contingency model elucidates the moderating role of a firm's R&D pipeline of drug candidates in clinical development and a firm's R&D expertise diversity across therapeutic categories. The empirics are based on a longitudinal analysis of a sample of therapeutic biotechnology firms in the United States over the period 2003–2010. We estimate negative binomial models to test our predictions. In support of our hypotheses, our findings indicate that reaching out to university alliances is positively related to firms’ publishing with academic co‐authors when firms develop stronger R&D pipeline and more diverse R&D expertise across therapeutic categories. The results of our study point to complementarities between collaborations with universities and a firm's investments in strengthening and diversifying its drug development pipeline in the process of public knowledge creation.
Phylogeny and biogeography of Calamagrostis (Poaceae: Pooideae: Poeae: Agrostidinae), description of a new genus, Condilorachia (Calothecinae), and expansion of Greeneochloa and Pentapogon (Echinopogoninae)
Authors: Peterson Paul M. , Soreng Robert J. , Romaschenko Konstantin , Barberá Patricia , Quintanar Alejandro , Aedo Carlos , Saarela Jeffery M. 
Published: December 2021

AbstractTo investigate the evolutionary relationships and biogeographical history among the species of Calamagrostis and other members of subtribes Agrostidinae, Calothecinae, Echinopogoninae, and Paramochloinae, we generated a phylogeny based on DNA sequences from one nuclear ribosomal (ITS) and three plastid regions (rpl32‐trnL spacer, rps16‐trnK spacer, and rps16 intron). Based on our phylogeny, we identified seven species groups (clades) within Calamagrostis: the Meridionalis group comprises two species from Central and South America, the Americana group comprises species from North America, the Deyeuxia and Epigeios groups comprise species from Eurasia, the Orientalis group comprises species from East Asia, the Purpurea group comprises species from Eurasia and North America, and the Calamagrostis group comprises species from Eurasia and North America. We hypothesize that Calamagrostis originated in North America with the primary split of the Meridionalis group, followed by split between the autochthonous Americana group and two future Eurasian branches encompassing all the remaining groups, which possibly dispersed into Eurasia independently. The molecular data suggest that hybridization and genomic introgression played a prominent role in the evolutionary history of Calamagrostis. We propose a new genus, Condilorachia, segregated from Trisetum s.l., with three species from South America for which we propose new combinations: Condilorachia bulbosa, Condilorachia brasiliensis, and Condilorachia juergensii; a new combination in Greeneochloa, Greeneochloa expansa; and the subsumption of Dichelachne into Pentapogon with 20 new combinations: Pentapogon avenoides, Pentapogon brassii, Pentapogon chaseianus, Pentapogon crinita, Pentapogon densus, Pentapogon frigidus, Pentapogon gunnianus, Pentapogon hirtella, Pentapogon inaequiglumis, Pentapogon lautumia, Pentapogon micrantha, Pentapogon parva, Pentapogon quadrisetus, Pentapogon rara, Pentapogon robusta, Pentapogon scaberulus, Pentapogon sclerophyllus, Pentapogon suizanensis, Pentapogon sieberiana, and Pentapogon validus. We provide a diagnosis, description, and a key to the species of Condilorachia.
Percutaneous radiofrequency ablation for hepatocellular carcinoma developed on non‐alcoholic fatty liver disease
Authors: Nguyen Nga , Rode Agnès , Trillaud Hervé , Aubé Christophe , Manichon Anne Frédérique , Hocquelet Arnaud , Paisant Anita , Dao Thong , Nahon Pierre , Ganne‐Carrié Nathalie , Blaise Lorraine , Cauchy François , Sutter Olivier , Séror Olivier , Nault Jean‐Charles 
Published: December 2021

AbstractBackground & AimsLong‐term outcomes after percutaneous radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in patients with non‐alcoholic fatty liver disease (NAFLD) have been poorly studied. We aim to determine the outcomes after multibipolar RFA in these patients compared to other aetiologies as well as the prognostic impact of metabolic syndrome (MS).MethodsPatients who underwent multibipolar RFA as the first treatment for HCC within Milan criteria (2008‐2018) were enrolled in this multicentre retrospective cohort from four tertiary centres in France. The association of MS and NAFLD with adverse events and outcomes after percutaneous RFA were assessed using Kaplan Meier method, log‐rank test and uni/multivariate analysis with the Cox models.ResultsAmong 520 patients, 390 patients (75%) had at least one component of MS including obesity (30%) and 95% had cirrhosis. Sixty‐two patients (12.6%) had NAFLD‐HCC, 225 (45.5%) had alcohol‐related‐HCC, 36 (7.3%) had HBV‐HCC and 171 (34.6%) had HCV‐HCC. Patients with NAFLD‐HCC were significantly older (median age 72.6 years, P < .001), more obese (median BMI 30.3 kg/m2, P < .001) and had more components of MS. Patients with NAFLD‐HCC achieved a median overall survival (OS) of 79 months (1‐year, 3‐year and 5‐year OS of 90%, 71% and 59%). There were no differences in morbidity, tumour recurrence and OS among patients with NAFLD‐HCC vs other aetiologies as well as no prognostic impact of metabolic components.ConclusionsPercutaneous multibipolar RFA is an efficient treatment in HCC patients with NAFLD or metabolic syndrome and achieved similar long‐term oncological outcomes compared to other aetiologies.
Genomic consequences of colonisation, migration and genetic drift in barn owl insular populations of the eastern Mediterranean
Authors: Machado Ana Paula , Topaloudis Alexandros , Cumer Tristan , Lavanchy Eléonore , Bontzorlos Vasileios , Ceccherelli Renato , Charter Motti , Kassinis Nicolaos , Lymberakis Petros , Manzia Francesca , Ducrest Anne‐Lyse , Dupasquier Mélanie , Guex Nicolas , Roulin Alexandre , Goudet Jérôme 
Published: December 2021

AbstractThe study of insular populations was key in the development of evolutionary theory. The successful colonisation of an island depends on the geographic context, and specific characteristics of the organism and the island, but also on stochastic processes. As a result, apparently identical islands may harbour populations with contrasting histories. Here, we use whole genome sequences of 65 barn owls to investigate the patterns of inbreeding and genetic diversity of insular populations in the eastern Mediterranean Sea. We focus on Crete and Cyprus, islands with similar size, climate and distance to mainland, that provide natural replicates for a comparative analysis of the impacts of microevolutionary processes on isolated populations. We show that barn owl populations from each island have a separate origin, Crete being genetically more similar to other Greek islands and mainland Greece, and Cyprus more similar to the Levant. Further, our data show that their respective demographic histories following colonisation were also distinct. On the one hand, Crete harbours a small population and maintains very low levels of gene flow with neighbouring populations. This has resulted in low genetic diversity, strong genetic drift, increased relatedness in the population and remote inbreeding. Cyprus, on the other hand, appears to maintain enough gene flow with the mainland to avoid such an outcome. Our study provides a comparative population genomic analysis of the effects of neutral processes on a classical island‐mainland model system. It provides empirical evidence for the role of stochastic processes in determining the fate of diverging isolated populations.
Do norms unintentionally increase stereotypical expressions? A randomised controlled trial
Authors: van Andel Chantal E. E. , Born Marise P. , van den Broek Walter W. , Stegers‐Jager Karen M. 
Published: December 2021

AbstractIntroductionImplicit biases of health professionals could cause biased judgements. Many anti‐bias interventions seem to be ineffective, and some even counterproductive. People tend to be compliant to standards describing what the majority of people finds or does, and this could cause people to think in a stereotype‐consistent manner. This study examines whether descriptive social norms such as ‘the majority of people have stereotypes’ (majority message), as often stated in interventions, actually increase people's stereotypes. To examine the effect of descriptive social norms (Hypothesis 1) and the effect of individual perceptions and preferences (Hypothesis 2a and 2b) on stereotypical expressions towards medical students.MethodsFirst, we determined which ethic stereotypes regarding medical students prevail in Dutch medical education (N = 52). Next, two similar randomised controlled trials, both with teachers and students, were carried out (N = 158 and N = 123, respectively), one with an East Asian student picture (ethnic minority) and one with a native Dutch student picture (ethnic majority). Participants were randomly assigned to either a majority‐message, minority‐message or no‐message condition, and rated the presented minority or majority picture on specific stereotypical features. Subsequently, participants described a typical day of that same student's life. These descriptions were rated for stereotypicality by two independent raters, who were blind for condition and stimulus. Inclusive work environment (IWC) and social dominance orientation (SDO) of participants were measured as indicators of individual perceptions and preferences.ResultsStereotypes were expressed towards both picture stimuli, yet message condition did not affect stereotypical expressions. SDO positively related to stereotypical expressions towards the East Asian student, whereas IWC positively related to stereotypical expressions towards the native Dutch student.ConclusionInterventions do not unintentionally increase stereotypes by communicating what the majority of people thinks or does. Individual perceptions and preferences are predictive of stereotypes, whereas descriptive social norms are not.
Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp
Authors: Travis Brady A. , Schumacher Maria A. 
Published: December 2021

AbstractBacteria must rapidly detect and respond to stressful environmental conditions. Guanosine tetraphosphate (ppGpp) is a universal stress signal that, in most bacteria, drives the reprograming of transcription at a global level. However, recent studies have revealed that the molecular mechanisms utilized by ppGpp to rewire bacterial transcriptomes are unexpectedly diverse. In Proteobacteria, ppGpp regulates the expression of hundreds of genes by directly binding to two sites on RNA polymerase (RNAP), one in combination with the transcription factor, DksA. Conversely, ppGpp indirectly regulates transcription in Firmicutes by controlling GTP levels. In this case, ppGpp inhibits enzymes that salvage and synthesize GTP, which indirectly represses transcription from rRNA and other promoters that use GTP for initiation. More recently, two different mechanisms of transcription regulation involving the direct binding of transcription factors by ppGpp have been described. First, in Francisella tularensis, ppGpp was shown to modulate the formation of a tripartite transcription factor complex that binds RNAP and activates virulence genes. Second, in Firmicutes, ppGpp allosterically regulates the transcription repressor, PurR, which controls purine biosynthesis genes. The diversity in bacterial ppGpp signaling revealed in these studies suggests the likelihood that additional paradigms in ppGpp‐mediated transcription regulation await discovery.
Governance and metagovernance systems for the Amazon
Authors: Martin Paul , Teles da Silva Solange , Duarte dos Santos Maurício , Dutra Carolina 
Published: December 2021

AbstractIn this article, we examine the existing governance of the Amazon and the potential for more robust collaborative governance involving the countries of the Amazon region and other stakeholders. Our focus is the metagovernance of the (multilevel and fragmented) national governance systems that have proven incapable of controlling the environmental and social harms affecting the region. We focus our transnational analysis on the Amazon Cooperation Treaty (ACT) and the Amazon Cooperation Treaty Organization (ACTO) and our intranational analysis on Brazil (which has sovereignty over the greatest part of the Amazon). We explore the governance challenges, and point to possible ways to address them.
Environment in institutional care settings as a promoting factor for older individuals’ mobility: A systematic review
Authors: Narsakka Noora , Suhonen Riitta , Stolt Minna 
Published: December 2021

AbstractBackgroundMobility is important for health and well‐being; however, older individuals in institutional care settings are relatively sedentary. The environment has an increased influence on mobility in older age due to changes in individual functioning; thus, environmental mobility support solutions for this population are needed.ObjectivesThe aim of this systematic review was to identify elements of the environment that have been used in the content and delivery of interventions to promote mobility and to assess the effects of these interventions on mobility outcomes.DesignA systematic literature search was conducted using CINAHL and MEDLINE from the earliest date through 30 September 2020 for randomised controlled trials, quasi‐experimental and pre‐post design studies. Inclusion and critical appraisal of articles were conducted by two independent researchers. Data were extracted and synthesised.Setting and participantsStudies were included if they had employed some element of the environment in the content and/or delivery of the intervention and had assessed mobility‐related outcomes of older individuals in institutional long‐term care settings providing full‐time care.MeasuresStudies were included if they reported data on mobility‐related outcomes including aspects of physical activity, physical function, life space and functional autonomy.ResultsEight studies were included. Physical, social and symbolic elements of the environment were utilised in the interventions. Positive effects on mobility outcomes were reported in exercise interventions utilising environmental elements mostly as supportive components.Conclusions and implicationsEmpirical evidence about effective mobility interventions employing elements of the environment as main intervention components is lacking. A serious dilemma exists about the need for older individuals’ independence and mobile/active late life and the lack of support for such initiatives in long‐term care. Given the emphasised relationship of the environment and mobility with age due to changes in functioning, environmental solutions require further examination.
Is it canine DUSN?
Authors: Aguirre Gustavo D. , Kazacos Kevin R. 
Published: December 2021

AbstractThe term retinopathy has been used to group several heterogeneous retinal abnormalities that are clearly acquired or are suspected/proposed to be inherited. Some share characteristic focal/multifocal hyperreflective tapetal lesions with a dark center, and areas of non‐tapetal depigmentation suggestive of patchy or diffuse outer retinal atrophy. Progression is variable, and some develop unilateral or bilateral fundus changes resembling the clearly inherited form of retinal degeneration referred to as PRA. In this Commentary and Review, we discuss the role of ocular larva migrans resulting in the entity we refer to as canine DUSN and suggest that it may be responsible for some of the retinal findings grouped under the retinopathy rubric that share this characteristic fundus lesion.
Mathematical Model of Macromolecular Drug Transport in a Partially Liquefied Vitreous Humor
Authors: Khoobyar Anahid , Penkova Anita N. , Humayun Mark S. , Sadhal Satwindar Singh 
Published: December 2021

Abstract
The purpose of this study is to investigate the effect of partial liquefaction (due to ageing) of the vitreous humor on the transport of ocular drugs. In our model, the gel part of the vitreous is treated as a Darcy-type porous medium. A spherical region within the porous part of vitreous is in a liquid state which, for computational purposes, is also treated as a porous medium but with a much higher permeability. Using the finite element method, a time-dependent, three-dimensional model has been developed to computationally simulate (using the Petrov–Galerkin method) the transport of intravitreally injected macromolecules where both convection and diffusion are present. From a fluid physics and transport phenomena perspective, the results show many interesting features. For pressure-driven flow across the vitreous, the flow streamlines converge into the liquefied region as the flow seeks the fastest path of travel. Furthermore, as expected, with increased level of liquefaction, the overall flow rate increases for a given pressure drop. We have quantified this effect for various geometrical considerations. The flow convergence into the liquefied region has important implication for convective transport. One effect is the clear diversion of the drug as it reaches the liquefied region. In some instances, the entry point of the drug in the retinal region gets slightly shifted due to liquefaction. While the model has many approximations and assumptions, the focus is illustrating the effect of liquefaction as one of the building blocks toward a fully comprehensive model.
Experimental and Numerical Study of Hydrodynamic and Heat Transfer Characteristics of Falling Film Over Metal Foam Layered Horizontal Tube
Authors: Jayakumar Arjun , Mani A. 
Published: December 2021

AbstractA novel nonintrusive technique based on an air-coupled ultrasonic transducer was used to study the hydrodynamic behavior of falling film over metal foam layered horizontal tube. Copper foam having a porosity of 90.5%, brazed over a copper tube of 25.4 mm diameter was used in this study. Falling film thickness distribution in the circumferential direction and the dynamic characteristics of falling film were studied in the falling film Reynolds number range of 356–715, and at a tube spacing of 5 mm and 15 mm. The falling film characteristics over metal foam layered horizontal tubes were compared with that over a plain horizontal tube surface. Heat transfer studies of falling film over metal foam layered tube were studied in an evaporator of a multi-effect desalination system by experiment. It was observed that the falling film heat transfer coefficient was enhanced 2.7 times by the application of metal foam over the plain horizontal tube. The measurements obtained from hydrodynamic and heat transfer studies were compared with the predictions made by a computational model and were found to be in good agreement. Metal foam properties required for the computational model were obtained using a microcomputed tomography-based study.
Too Many Cooks, Not Enough Gourmets: Examining Provision and Use of Feedback for the Developing Athlete
Authors: Taylor Jamie , Collins Dave , Cruickshank Andrew 
Published: December 2021

Feedback from coaches and other stakeholders is well established as having a significant impact on the development of performance. This study investigated perceptions of the feedback process and the sense-making of athletes transitioning to elite sport. Specifically, the aims were to (a) investigate the number of feedback providers young players reported through their talent development journey, (b) understand the degree of coherence that players perceived from this feedback, and (c) explore the sense-making process of individual players by understanding their decision criteria. The findings suggest that pathway athletes were offered an excess of feedback from multiple sources, often incoherently. Yet, players lacked an appropriate sense-making process to appreciate, critically reflect on, and apply feedback. Given the implications for talent development, we offer suggestions for the coach and system to optimize feedback processes and develop gourmet consumers.
Dependence of discharge, channel area, and flow velocity on river stage and a refutation of Manning’s equation
Authors: Criss* Robert E. 
Published: December 2021

ABSTRACT
Field data reveal how the discharge (Q), channel area (A), and average water velocity (Vavg) of natural streams functionally depend on the effective stage (h) above channel bottom. A graphical technique allows the level that corresponds to a dry channel, denoted “h0,” to be determined, permitting the dependent variables Q, A, and Vavg to all be expressed as simple functions of h, equal to hL – h0, where hL is the local stage that is typically reported relative to an arbitrary, site-specific datum. Once h0 is known, plots of log Q, log A, and log Vavg versus log h can be constructed using available data. These plots define strong, nearly linear trends for which the slopes (1) quantify the power relationships among these variables; (2) show that Vavg varies nearly linearly with h, unlike behaviors assumed in the Chezy and Manning equations; (3) distinguish the individual contributions of A and Vavg to discharge, which is their product; (4) provide quantitative means with which to compare different sites; and (5) offer new insights into the character and dynamics of natural streams.
Links of planetary energetics to moon size, orbit, and planet spin: A new mechanism for plate tectonics
Authors: Hofmeister* Anne M. , Criss Robert E. , Criss† Everett M. 
Published: December 2021

ABSTRACT
Lateral accelerations require lateral forces. We propose that force imbalances in the unique Earth-Moon-Sun system cause large-scale, cooperative tectonic motions. The solar gravitational pull on the Moon, being 2.2× terrestrial pull, causes lunar drift, orbital elongation, and an ~1000 km radial monthly excursion of the Earth-Moon barycenter inside Earth’s mantle. Earth’s spin superimposes an approximately longitudinal 24 h circuit of the barycenter. Because the oscillating barycenter lies 3500–5500 km from the geocenter, Earth’s tangential orbital acceleration and solar pull are imbalanced. Near-surface motions are enabled by a weak low-velocity zone underlying the cold, brittle lithosphere: The thermal states of both layers result from leakage of Earth’s internal radiogenic heat to space. Concomitantly, stress induced by spin cracks the lithosphere in a classic X-pattern, creating mid-ocean ridges and plate segments. The inertial response of our high-spin planet with its low-velocity zone is ~10 cm yr–1 westward drift of the entire lithosphere, which largely dictates plate motions. The thermal profile causes sinking plates to thin and disappear by depths of ~200–660 km, depending on angle and speed. Cyclical stresses are effective agents of failure, thereby adding asymmetry to plate motions. A comparison of rocky planets shows that the presence and longevity of volcanism and tectonism depend on the particular combination of moon size, moon orbital orientation, proximity to the Sun, and rates of body spin and cooling. Earth is the only rocky planet with all the factors needed for plate tectonics.