bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructure and Properties of Atmospheric Plasma Sprayed (Al,Cr)2O3–TiO2 Coatings from Blends
Authors: Grimm Maximilian , Conze Susan , Berger Lutz-Michael , Drehmann Rico , Lampke Thomas 
Published: November 2021

AbstractCoatings prepared from chromia-rich (Al,Cr)2O3solid solution (ss) feedstock powders are intended to improve the properties of Cr2O3coatings, but are rarely studied so far. In this work, the processability of a commercial (Al,Cr)2O3solid solution (ss) powder containing 78 wt.% Cr2O3by atmospheric plasma spraying (APS), the corresponding coating microstructures and properties were investigated. Possible further improvements were expected by blending with 2, 23 and 54 wt.% TiOxpowder. For comparison, plain Cr2O3and TiOxcoatings were studied as well. The microstructures were analyzed using SEM, EDS and XRD measurements. Hardness (HV0.3) was measured, as well as the dry unidirectional sliding wear resistance and the abrasion wear resistance (ASTM G65). Moreover, the corrosion and electrical insulating properties were measured. The (Al,Cr)2O3ss showed only a small change of the composition, and the formation ofγ-Al2O3, as found for alumina-rich (Al,Cr)2O3ss powders, was avoided. Compared to the plain chromia coating, some improvements of the processability and coating properties for the ss (Al,Cr)2O3coating were found. The most balanced coating performance was achieved by blending the ss (Al,Cr)2O3with 2 wt.% TiOx, as this coating showed both a high sliding and abrasion wear resistance, in combination with a high corrosion resistance.
ENIGMA + COINSTAC: Improving Findability, Accessibility, Interoperability, and Re-usability
Authors: Turner Jessica A. , Calhoun Vince D. , Thompson Paul M. , Jahanshad Neda , Ching Christopher R. K. , Thomopoulos Sophia I. , Verner Eric , Strauss Gregory P. , Ahmed Anthony O. , Turner Matthew D. , Basodi Sunitha , Ford Judith M. , Mathalon Daniel H. , Preda Adrian , Belger Aysenil , Mueller Bryon A. , Lim Kelvin O. , van Erp Theo G. M. 
Published: November 2021

AbstractThe FAIR principles, as applied to clinical and neuroimaging data, reflect the goal of making research products Findable, Accessible, Interoperable, and Reusable. The use of the Collaborative Informatics and Neuroimaging Suite Toolkit for Anonymized Computation (COINSTAC) platform in the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium combines the technological approach of decentralized analyses with the sociological approach of sharing data. In addition, ENIGMA + COINSTAC provides a platform to facilitate the use of machine-actionable data objects. We first present how ENIGMA and COINSTAC support the FAIR principles, and then showcase their integration with a decentralized meta-analysis of sex differences in negative symptom severity in schizophrenia, and finally present ongoing activities and plans to advance FAIR principles in ENIGMA + COINSTAC. ENIGMA and COINSTAC currently represent efforts toward improved Access, Interoperability, and Reusability. We highlight additional improvements needed in these areas, as well as future connections to other resources for expanded Findability.
Future time perspective and trust in government: The mediation of the consideration of future consequences
Authors: Zhi Kuiyun , Yang Jian , Chen Si , Chen Yongjin , Akebaijiang Niyazi , Liu Meimei , Xia Lingxiang 
Published: November 2021

AbstractEvidence suggests that college students’ future-related feelings and cognition may influence their trust in government. This study aims to explore whether the association between college students’ future time perspective and trust in government is mediated through the consideration of future consequences (CFC). A cross-sectional survey was used to collect data from 1,617 college students (86.6% women) aged 17 to 31 years in China via an online questionnaire. The results showed that the students’ positive, negative and confused future orientation was positively associated with their trust in government. The consideration of far- future consequences positively mediated the relationship between a positive future orientation and trust in government. These findings support the possibility to evaluate college students’ government trust level according to their future orientation, which will improve their positive political participation.
Corrigendum to ‘Endoscopy for Hecke categories, character sheaves and representations’
Authors: Lusztig George , Yun Zhiwei 
Published: November 2021

Abstract
We fix an error on a

$3$

-cocycle in the original version of the paper ‘Endoscopy for Hecke categories, character sheaves and representations’. We give the corrected statements of the main results.
A few remarks on Pimsner–Popa bases and regular subfactors of depth 2
Authors: Bakshi Keshab Chandra , Gupta Ved Prakash 
Published: November 2021

AbstractWe prove that a finite index regular inclusion of$II_1$-factors with commutative first relative commutant is always a crossed product subfactor with respect to a minimal action of a biconnected weak Kac algebra. Prior to this, we prove that every finite index inclusion of$II_1$-factors which is of depth 2 and has simple first relative commutant (respectively, is regular and has commutative or simple first relative commutant) admits a two-sided Pimsner–Popa basis (respectively, a unitary orthonormal basis).
THEORISING THE LOCAL ADAPTATION OF TRANSNATIONAL CERTIFICATION STANDARDS
Authors: Gillespie John , H Do Ha 
Published: November 2021

AbstractOver the last three decades, transnational certification standards have proliferated to fill perceived ‘governance gaps’ in developing countries. Transnational non-governmental organisations and private standards-setting agencies have developed standards that cover a vast range of areas such as labour rights, social justice and environmental protection. As a form of private transnational regulation, certification standards travel through transnational production networks that link lead firms in developed countries with supplier firms in developing countries. This article draws on a case study about coffee certification to challenge the conventional understanding of transnational certification as a contractual conduit that transfers encoded certification standards from senders to receivers. It shows how transnational certification standards interact with, and remake local regulatory landscapes as they pass through. This interaction between global and local knowledge compels us to see transnational standards as a protean, highly localised regulatory process rather than stable universal norms. The article concludes that transnational certification does not function like an integrated ‘joined-up’ process and it is better understood as a mode of polycentric regulation that decentres and fragments transnational norms and standards.
Vestibular evaluation following cochlear implantation in patients with inner-ear anomalies
Authors: Hosseinzadeh F , Asghari A , Moradi-Lakeh M , Pourbakht A , Farhadi M , Daneshi A , Boroujeni M K , Mohseni M , Mohammadi S Saeed 
Published: November 2021

AbstractObjectiveThis cross-sectional study investigated vestibular function outcomes after cochlear implantation in patients with inner-ear anomalies.MethodsTwenty-two patients with bilateral symmetric inner-ear anomalies and 28 patients with normal inner ears were included. All were congenitally or progressively deaf persons implanted unilaterally during the previous 15 years. Vestibular system function was assessed by vestibular-evoked myogenic potential and bithermal caloric tests.ResultsThe vestibular-evoked myogenic potential abnormality rate in implanted ears with an inner-ear anomaly was 81.8 per cent, compared with 39.3 per cent in implanted ears with normal anatomy. In the non-implanted sides, the rate was 45.5 per cent (10 out of 22 cases) in the inner-ear anomaly patients compared with 17.9 per cent in patients with normal inner-ear structure. The respective abnormal caloric test rates in inner-ear anomaly versus normal anatomy patients were 81.8 per cent and 17.9 per cent (implanted ears), 77.3 per cent and 14.3 per cent (non-implanted sides).ConclusionInner-ear anomaly and implantation were both associated with more vestibular-evoked myogenic potential abnormalities; when occurring together, these factors showed a synergistic effect. Caloric test abnormality is mainly dependent on the presence of an inner-ear anomaly, but implantation is not associated with caloric abnormality.
The belief in mining: How imageries of other mines may brighten Arctic minescapes
Authors: Solbär Tiina Lovisa 
Published: November 2021

AbstractThe article discusses how promising outlooks and favourable memories of past and distant mining ventures are employed in the view of a minein spe. The study utilises interview quotes and written narratives pertaining to a case of mine development in Swedish Pajala and neighbouring Finnish Kolari (the Northland project 2004–2014), located above the Arctic Circle, for explicating this. Its theoretical framework includes the concept of minescape and the ideas of past presences and anticipated futures, which support capturing (the temporality of) the sociocultural and discursive dimensions of mining alongside with its physicality. Previous and distant experiences with mines appeared readily abstracted and brought into the current debate, forgetting about contexts, that is, about any historical or geographical contingencies. This kind of temporal and spatial referencing is seen to represent an imaginative practice which, as it is argued, gains an enhanced role in tandem with the increasing market dependency and volatility of the extractive business. By attending to the meaning-making based on remembering, and forgetting, in the context of experiences made with mining in the past or elsewhere, the article contributes to our understanding of the present-day role of mining heritage.
Contested Grasslands: Commons and the Unequal Land-Costs to Sustain Soil Fertility in Preindustrial Agriculture
Authors: Güldner Dino 
Published: November 2021

AbstractMaintaining soil fertility was the most pressing problem in preindustrial agriculture. Prior to the arrival of industrial inputs, farmers relied on ecological soil replenishment processes and biological fertilizing techniques to sustain the productivity of soil. Central European farmers actively managed the cycling of nutrients by keeping livestock. Farm animals provided the means to recycle nutrients from crop production and to transfer nutrients from land-use systems dedicated for biomass extraction, such as grasslands. This article explores the unequal distribution of these vital resources in the Manor Bruck, Austria, and its impact on landlord’s and peasant’s abilities to meet the “land costs” of sustaining soil fertility. The article tests the hypothesis as to whether inequality was a major driver for unsustainable farming practices and the degradation of agro-ecosystems in the long run. Focal points are commons and communal land-use systems and their role in cycling nutrients through the agricultural landscape. Commons in the Manor Bruck comprised vast grasslands, which provided an important ecological buffer to balance the continuous export of nutrients from crop production for all actors. The aim is to demonstrate how social conflict emerging from the competition over commons guides us to the specific sustainability challenges faced by farmers.
Lebermetastasen: aktueller Stand der chirurgischen Behandlungsmöglichkeiten
Authors: Kremer Michael , Manzini Giulia , Hartel Mark 
Published: November 2021

Zusammenfassung. Metastasen sind die häufigsten Raumforderungen in der Leber. Auch wenn die aktuelle Therapie von Lebermetastasen interdisziplinär und individuell breit aufgestellt ist, bleibt – falls möglich – die chirurgische Entfernung als Goldstandard die Therapie der Wahl. Die Fortschritte in der chirurgischen, systemischen und interventionellen Therapie der letzten Jahre haben zu einem multimodalen Therapieansatz, individualisiert auf das Erkrankungsbild und den Zustand des Patienten, geführt. Dadurch gelingt es, auch initial nichtresektable Befunde durch «Down-Staging» in einen resektablen Zustand zu überführen. Neoadjuvante Chemotherapie und zwei- beziehungsweise mehrzeitige Leberresektionen mit oder ohne Pfortaderembolisation sind hier zu nennen. Auch die Fortschritte in der Chirurgie und des perioperativen interdisziplinären Managements tragen eine entscheidende Rolle dazu bei, das Gesamtüberleben zu verlängern.
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
Authors: Huh Jin Young , Saltiel Alan R. 
Published: November 2021

AbstractNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is strongly associated with obesity-related ectopic fat accumulation in the liver. Hepatic lipid accumulation encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma. Given that dysregulated hepatic lipid metabolism may be an onset factor in NAFLD, understanding how hepatic lipid metabolism is modulated in healthy subjects and which steps are dysregulated in NAFLD subjects is crucial to identify effective therapeutic targets. Additionally, hepatic inflammation is involved in chronic hepatocyte damage during NAFLD progression. As a key immune signaling hub that mediates NF-κB activation, the IκB kinase (IKK) complex, including IKKα, IKKβ, and IKKγ (NEMO), has been studied as a crucial regulator of the hepatic inflammatory response and hepatocyte survival. Notably, TANK-binding kinase 1 (TBK1), an IKK-related kinase, has recently been revealed as a potential link between hepatic inflammation and energy metabolism. Here, we review (1) the biochemical steps of hepatic lipid metabolism; (2) dysregulated lipid metabolism in obesity and NAFLD; and (3) the roles of IKKs and TBK1 in obesity and NAFLD.
Deep learning-based quantification of temporalis muscle has prognostic value in patients with glioblastoma
Authors: Mi Ella , Mauricaite Radvile , Pakzad-Shahabi Lillie , Chen Jiarong , Ho Andrew , Williams Matt 
Published: November 2021

Abstract
Background
Glioblastoma is the commonest malignant brain tumour. Sarcopenia is associated with worse cancer survival, but manually quantifying muscle on imaging is time-consuming. We present a deep learning-based system for quantification of temporalis muscle, a surrogate for skeletal muscle mass, and assess its prognostic value in glioblastoma.

Methods
A neural network for temporalis segmentation was trained with 366 MRI head images from 132 patients from 4 different glioblastoma data sets and used to quantify muscle cross-sectional area (CSA). Association between temporalis CSA and survival was determined in 96 glioblastoma patients from internal and external data sets.

Results
The model achieved high segmentation accuracy (Dice coefficient 0.893). Median age was 55 and 58 years and 75.6 and 64.7% were males in the in-house and TCGA-GBM data sets, respectively. CSA was an independently significant predictor for survival in both the in-house and TCGA-GBM data sets (HR 0.464, 95% CI 0.218–0.988, p = 0.046; HR 0.466, 95% CI 0.235–0.925, p = 0.029, respectively).

Conclusions
Temporalis CSA is a prognostic marker in patients with glioblastoma, rapidly and accurately assessable with deep learning. We are the first to show that a head/neck muscle-derived sarcopenia metric generated using deep learning is associated with oncological outcomes and one of the first to show deep learning-based muscle quantification has prognostic value in cancer.
Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs
Authors: Warburton Alix , Markowitz Tovah E. , Katz Joshua P. , Pipas James M. , McBride Alison A. 
Published: November 2021

AbstractOncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single copy or as tandem repeats of viral DNA interspersed with, or without, host DNA. Integration occurs frequently in common fragile sites susceptible to tandem repeat formation and the flanking or interspersed host DNA often contains transcriptional enhancer elements. When co-amplified with the viral genome, these enhancers can form super-enhancer-like elements that drive high viral oncogene expression. Here we compiled highly curated datasets of HPV integration sites in cervical (CESC) and head and neck squamous cell carcinoma (HNSCC) cancers, and assessed the number of breakpoints, viral transcriptional activity, and host genome copy number at each insertion site. Tumors frequently contained multiple distinct HPV integration sites but often only one “driver” site that expressed viral RNA. As common fragile sites and active enhancer elements are cell-type-specific, we mapped these regions in cervical cell lines using FANCD2 and Brd4/H3K27ac ChIP-seq, respectively. Large enhancer clusters, or super-enhancers, were also defined using the Brd4/H3K27ac ChIP-seq dataset. HPV integration breakpoints were enriched at both FANCD2-associated fragile sites and enhancer-rich regions, and frequently showed adjacent focal DNA amplification in CESC samples. We identified recurrent integration “hotspots” that were enriched for super-enhancers, some of which function as regulatory hubs for cell-identity genes. We propose that during persistent infection, extrachromosomal HPV minichromosomes associate with these transcriptional epicenters and accidental integration could promote viral oncogene expression and carcinogenesis.
Patient and caregiver outcomes with levodopa-carbidopa intestinal gel in advanced Parkinson’s disease
Authors: Valldeoriola Francesc , Catalán María José , Escamilla-Sevilla Francisco , Freire Eric , Olivares Jesús , Cubo Esther , García Diego Santos , Calopa Matilde , Martínez-Martín Pablo , Parra Juan Carlos , Arroyo Gloria , Arbelo José Matías 
Published: November 2021

AbstractLevodopa-carbidopa intestinal gel (LCIG) has shown to be efficacious in motor and non-motor symptoms (NMS). Nevertheless, studies with patient Quality of Life (QoL) as a primary endpoint are scarce. To assess the effect of LCIG on Advanced Parkinson’s Disease (APD) patients QoL. Secondarily, the impact on motor symptoms and NMS, emotional well-being, treatment satisfaction, and caregiver QoL, stress, disease burden, anxiety, depression, and work impairment were also investigated. In this prospective, 6-month multicenter postmarketing observational study, LCIG was administered to 59 patients with APD. Endpoints were assessed using validated scales and questionnaires. LCIG significantly improved patient QoL (PDQ-39 mean change ± standard deviation from baseline, −12.8 ± 14.6; P < 0.0001), motor symptoms (UPDRS-III in “On,” −6.5 ± 11.8; P = 0.0002), NMS (NMSS, −35.7 ± 31.1; P < 0.0001), mood (Norris/Bond-Lader VAS, −6.6 ± 21.1; P = 0.0297), fatigue (PFS-16, −0.6 ± 1.0; P = 0.0003), depression (BDI-II, −5.1 ± 9.4; P = 0.0002), anxiety (BAI, −6.2 ± 9.6; P < 0.0001), and patient treatment satisfaction (SATMED-Q, 16.1 ± 16.8; P < 0.0001). There were significant correlations between the change from baseline to 6 months between PDQ-39 and UPDRS-IV, NMSS, BAI, BDI-II, AS, and PFS-16 scores, and Norris/Bond-Lader alertness/sedation factor. Caregiver anxiety also improved (Goldberg anxiety scale, −1.1 ± 1.0; P = 0.0234), but the clinical relevance of this finding is questionable. The serious adverse events reported were similar to those previously described for LCIG. In patients with APD, LCIG improves QoL, motor symptoms and NMS, emotional well-being, and satisfaction with the treatment. Improvement in patient QoL is associated with improvements in motor complications, NMS, anxiety, depression, apathy and fatigue. Improvements in patients’ QoL does not correspond with improvements in caregivers’ QoL or burden.
Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts
Authors: Shi Fangyi , Aloufi Noof , Traboulsi Hussein , Trempe Jean-François , Eidelman David H. , Baglole Carolyn J. 
Published: November 2021

AbstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate toxic responses to dioxin. However, the role of the AhR in the regulation of cellular physiology has only recently been appreciated, including its ability to control cell cycle progression and apoptosis by unknown mechanisms. We hypothesized that the AhR enhances the activation of the AKT serine/threonine kinase (Akt) pathway to promote cell survival. Utilizing AhR knock-out (Ahr−/−) and wild-type (Ahr+/+) mouse lung fibroblasts (MLFs), we found that Ahr−/− MLFs have significantly higher basal Akt phosphorylation but that AhR did not affect Akt phosphorylation in MLFs exposed to growth factors or AhR ligands. Basal Akt phosphorylation was dependent on PI3K but was unaffected by changes in intracellular glutathione (GSH) or p85α. There was no significant decrease in cell viability in Ahr−/− MLFs treated with LY294002—a PI3K inhibitor—although LY294002 did attenuate MTT reduction, indicating an affect on mitochondrial function. Using a mass spectrometry (MS)-based approach, we identified several proteins that were differentially phosphorylated in the Ahr−/− MLFs compared to control cells, including proteins involved in the regulation of extracellular matrix (ECM), focal adhesion, cytoskeleton remodeling and mitochondrial function. In conclusion, Ahr ablation increased basal Akt phosphorylation in MLFs. Our results indicate that AhR may modulate the phosphorylation of a variety of novel proteins not previously identified as AhR targets, findings that help advance our understanding of the endogenous functions of AhR.
The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion
Authors: Haque Omar , Pendexter Casie A. , Wilks Benjamin T. , Hafiz Ehab O. A. , Markmann James F. , Uygun Korkut , Yeh Heidi , Tessier Shannon N. 
Published: November 2021

AbstractIn transplantation, livers are transported to recipients using static cold storage (SCS), whereby livers are exposed to cold ischemic injury that contribute to post-transplant risk factors. We hypothesized that flushing organs during procurement with cold preservation solutions could influence the number of donor blood cells retained in the allograft thereby exacerbating cold ischemic injury. We present the results of rat livers that underwent 24 h SCS after being flushed with a cold University of Wisconsin (UW) solution versus room temperature (RT) lactated ringers (LR) solution. These results were compared to livers that were not flushed prior to SCS and thoroughly flushed livers without SCS. We used viability and injury metrics collected during normothermic machine perfusion (NMP) and the number of retained peripheral cells (RPCs) measured by histology to compare outcomes. Compared to the cold UW flush group, livers flushed with RT LR had lower resistance, lactate, AST, and ALT at 6 h of NMP. The number of RPCs also had significant positive correlations with resistance, lactate, and potassium levels and a negative correlation with energy charge. In conclusion, livers exposed to cold UW flush prior to SCS appear to perform worse during NMP, compared to RT LR flush.