bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance and Safety of PowerGlide Pro® Extended Dwell Peripheral Catheters in an Emergency Medicine Unit: A Prospective Observational Study
Authors: Mussa¹ Baudolino , Mosca¹ Christian , Restivo¹ Angela , Robasto¹ Giulia , Pivetta¹ Emanuele , Lupia Enrico 
Published: January 2025

Abstract

Background: The increasing complexity of hospital care has led to a growing demand for versatile vascular access devices. Extended dwell peripheral (EDP) catheters, such as the PowerGlide Pro®, have emerged as potential alternatives to both short-term peripheral and long-term central venous catheters.
Objective: To evaluate the performance, safety, and efficacy of the PowerGlide Pro® EDP catheter in a sub-intensive care unit setting, comparing its outcomes to historical data on other vascular access devices.
Methods: A prospective observational study was conducted on 300 patients requiring intravenous therapy for ≥7 days in the Emergency Medicine Unit at A.O.U. Città della Salute e della Scienza di Torino, Italy, from December 2019 to October 2020. Primary outcomes included complication rates, reasons for removal, and duration of catheter use.
Results: Of 283 successfully placed devices, 23 complications (8.1%) were observed, with only 12 (4.2%) resulting in device removal. The average duration of catheter use was 7.26 ± 5.51 days (range: 1-31 days). Ultrasound-guided insertion was successful in 94.7% of cases.
Conclusion: The PowerGlide Pro® demonstrated superior performance with a low rate of complications requiring removal compared to traditional peripheral catheters and comparable performance to midline and PICC devices. These findings suggest its potential as an effective alternative for medium-term vascular access in sub-intensive care settings.
Contextual factors’ Correlates on Teachers’ ICT Beliefs and their ICT use in urban slum public basic schools in Ghana
Authors: Baako Issah , Abroampa Winston Kwame , Osei Eric Opoku 
Published: January 2025

Abstract

This study examined the implementation of Information and Communications Technology for Education (ICT4E) in public basic schools situated in urban slums in Ghana. The research focused on contextual factors, teachers' ICT beliefs, and the extent of ICT usage in these educational settings. The primary objective is to investigate the relationships between contextual factors, teachers' beliefs about ICT, and their actual use of ICT in the classroom. Data were collected from 179 randomly selected teachers through a structured questionnaire using a cross-sectional survey design. The collected data were then analyzed using IBM SPSS v.26 and Pearson's correlation coefficient to examine the associations between the variables. The results reveal a weak but statistically significant relationship between contextual factors and teachers' ICT usage, suggesting that the environmental context plays a role in ICT adoption, albeit with limited influence. The study also finds a weak and statistically insignificant relationship between contextual factors and teachers' ICT beliefs, indicating that external conditions may not heavily impact teachers' attitudes toward ICT. Furthermore, the study identifies a very weak but statistically significant relationship between teachers' ICT beliefs and their ICT usage, implying that teachers' beliefs do have a minimal role in how they integrate technology into their teaching. The findings underscore the significance of considering contextual factors when implementing ICT in schools, particularly in resource-constrained environments such as urban slums. The study advocates for comprehensive and targeted interventions that address both the contextual challenges and the need to foster positive ICT beliefs among teachers. These interventions are crucial for establishing equitable and high-quality technology-enhanced learning environments that can yield long-term educational benefits.
Novel Ectodysplasin-A Variants: Structural and Functional Basis of Hypohidrotic Ectodermal Dysplasia
Authors: Ranjan Prashant , Devi Chandra , Bansal Rajesh , Srivast Vandita , Srivast Vinay Kumar , Das Parimal 
Published: January 2025

Abstract

This study investigates two novel variants in the EDA, c.680G > A (p.G227E) and c.649_666del (Δ215–220), identified in X-linked ectodermal dysplasia and syndromic tooth agenesis cases. These variants were identified through Sanger sequencing and mapped to highly conserved regions of EDA. Bioinformatics tools consistently classified them as deleterious, with significant disruptions predicted in protein stability, hydrophobicity, and secondary structure. Structural analysis revealed that p.G227E caused a glycine-to-glutamic acid substitution, altering hydrophobicity and secondary structure, while Δ215–220 disrupted a conserved hydrophobic region, leading to increased protein instability Functional studies revealed reduced expression of EDA and WNT4 proteins, alongside increased IκB levels and decreased NF-κB mRNA expression, indicating impaired EDA-NF-κB signaling. Subcellular localization analyses demonstrated diminished cytoplasmic expression of the EDA Variants proteins, corroborated by in silico predictions. Post-translational modifications (PTMs) and gene ontology (GO) analyses revealed alterations in processes critical for ectodermal development, including macromolecule biosynthesis, nitrogen metabolism, and receptor signaling. Molecular dynamics simulations highlighted increased rigidity, compact structure, and reduced flexibility in the EDA variants proteins compared to EDA Wild Type (WT). Interestingly, neither variant significantly impacted calcium or mitochondrial potential under normal experimental conditions, suggesting their pathogenic effects arise primarily from disrupted protein interactions and signaling pathways. This study integrates molecular, bioinformatics, and functional analyses to elucidate the pathogenicity of these novel EDA variants, providing insights into ectodermal dysplasia mechanisms and paving the way for future therapeutic strategies targeting these EDA variants.
What Drives House Prices? A Linear Regression Approach to Size, Condition, and Features
Authors: Ju Xiaolin , Chakma Vaskar , Amin Misbahul , Chakma Joy Arkhid 
Published: January 2025

Abstract

This research examines the key factors that influence house prices, focusing on how size, condition, and structural features contribute to property valuation. A multivariate analysis using a Linear Regression model was conducted to assess the relationships between crucial features such as square footage, number of bedrooms, bathrooms, floors, and property condition. The analysis revealed that square footage and bathrooms exhibit the strongest positive correlations with house prices (both with correlation values of 0.76), indicating their significant impact on property valuation. In contrast, factors like condition and view demonstrated weaker correlations, suggesting a more limited influence. The Linear Regression model achieved an R-squared value of 0.75, explaining 75% of the variation in house prices based on these features. While the model effectively highlights key price determinants, its limitations in handling non-linear relationships and sensitivity to outliers are noted. This study emphasizes the importance of a nuanced, data-driven approach in understanding house price dynamics, offering valuable insights for buyers, sellers, and industry professionals. Future work could explore advanced predictive models and incorporate additional features to enhance forecasting accuracy.
Urolithiasis in early childhood: treatment approach illustrated by a case report
Authors: Shchapov N. F. , Keshishian E. S. , Telyatnikov N. A. , Bullikh P. V. , Epishov V. A. , Degtyarev A. S. , Kulikov D. V. 
Published: January 2025

Urolithiasis in young children is a rare condition requiring particular attention due to its potential complexity and the necessity of an individualized treatment approach. This article presents a case study of a 5-year-old child treated for urolithiasis following acute lymphoblastic leukemia therapy. Case report. A 5-year-old boy presented at Ilyinskaya Hospital with right ureteral obstruction. Ultrasound performed due to abdominal pain revealed dilation of the kidney’s collecting system (calyces up to 12 mm, renal pelvis up to 16 mm) and the proximal ureter (up to 6 mm) on the right side. A solitary calculus obstructing the right ureter was identified via computed tomography. The child underwent emergency surgery, including cystoureteroscopy, lithoextraction from the right ureter, and placement of an internal stent. The postoperative period was marked by infectious complications, which were effectively managed. The internal stent was removed on the 6th postoperative day. The patient remained under hematology and nephrology follow-up, with no recurrence of urolithiasis reported.Conclusion: This study emphasizes the necessity of a comprehensive approach in managing pediatric urolithiasis, including careful monitoring and appropriate treatment, particularly in the presence of underlying conditions that may exacerbate or contribute to the disease. Special attention is given to adequate postoperative care and prevention of recurrence, which are essential for a favorable outcome and minimizing the risk of stone reformation.
The Relationship Between The Perception of Professional Identity and The Professionalism Level of Medical Students
Authors: Luthfianasari Luthfianasari , Pamungkasari Eti Poncorini , Hermasari Bulan Kakanita 
Published: January 2025

Background: Medical education aims to create professional doctors through standardized methods according to the needs of public health services. A doctor must have a professional attitude and ability as a form of professional responsibility. Professionalism is often associated with professional identity, where professionalism is deemed necessary to be supported by professional identity. This study aims to determine the relationship between perceptions of professional identity and medical students’ professionalism level.Methods: A cross-sectional study was conducted in a faculty of medicine in Indonesia. The respondents were medical students from 3 cohorts: 2019, 2020, and 2021. The data analysis used the Spearman correlation test.Results: A total of 276 respondents consist of 94 (34.1%) male and 182 (65.9%) female respondents. The mean scores for the professionalism level for batches 2019, 2020, and 2021, respectively, were 160.23, 160.83, and 162.07. The mean scores for the perception of professional identity for batches 2019, 2020, and 2021, respectively, were 86.89, 89.26, and 89.18. The Spearman correlation test results showed there was a relationship between the professionalism level and perceptions of professional identity (p <0.001; r = 0,508), but there was no relationship between the professionalism level and study period (p = 0.081; r = -0.105).Conclusion: There is a relationship between perceptions of professional identity and the professionalism level of medical students.
PROSES MENEMUKAN KEBERMAKNAAN HIDUP PADA DANAR AND THE BLANGKON
Authors: Syifa' Farichah Nurus , Nilawaty Azzah 
Published: January 2025

Proses menuju kebermaknaan hidup dimulai dari keadaan tanpa arti menjadi memiliki makna. Tujuan dari penelitian ini adalah untuk menggambarkan bagaimana proses pencarian makna hidup pada Danar and the Blangkon. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif fenomenologi. Dua anggota Danar and the Blangkon menjadi informan penelitian yang diwawancarai secara semi terstruktur. Keduanya memiliki masa lalu yang kelam dan berbeda agama. Data dianalisis dengan menggunakan pendekatan Miles and Huberman dan validitas ditentukan melalui memberchecking. Hasil penelitian menunjukkan bahwa Danar and the Blangkon mengalami ketidakbermaknaan saat bekerja di dunia malam. Namun, mereka tidak pasif dalam kondisi tersebut dan berusaha untuk mencari makna. Danar and the Blangkon memutuskan untuk keluar dari pekerjaan dunia malam dan mengevaluasi diri. Evaluasi diri Danar and the Blangkon dimulai saat D1 bertemu seorang ustaz dan D2 bertemu dengan seorang pastor. Kedua informan memperoleh nilai khusus dari perubahan kondisinya. Salah satu personil memperoleh nilai sak madyane sehingga tidak berambisi pada duniawi dan personil satunya memperoleh nilai ati menep yang membuatnya dapat mengontrol diri sehingga dapat menyikapi permasalahan dengan bijak. Dengan demikian Danar and the Blangkon yang memiliki masa lalu yang kelam mampu menemukan kebermaknaan hidup dan meningkatkan nilai diri melalui proses refleksi dan keterlibatan dalam aktivitas positif. Implikasi penelitian ini adalah mengembangkan resiliensi diri, dukungan sosial, dan spiritualitas untuk membantu seseorang yang mengalami pengalaman yang kelam dalam menemukan makna hidup dan membentuk nilai diri mereka.
Large-Scale Plasma Proteomics Improves Prediction of Peripheral Artery Disease in Individuals With Type 2 Diabetes: A Prospective Cohort Study
Authors: Yu Hancheng , Zhang Jijuan , Qian Frank , Yao Pang , Xu Kun , Wu Ping , Li Rui , Qiu Zixin , Li Ruyi , Zhu Kai , Li Lin , Geng Tingting , Yu Xuefeng , Li Danpei , Liao Yunfei , Pan An , Liu Gang 
Published: January 2025

OBJECTIVE
Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore the relationship between plasma proteomics and PAD in individuals with T2D, and assess whether proteomics could refine PAD risk prediction.

RESEARCH DESIGN AND METHODS
This cohort study included 1,859 individuals with T2D from the UK Biobank. Multivariable-adjusted Cox regression models were used to explore associations between 2,920 plasma proteins and incident PAD. Proteins were further selected as predictors using least absolute shrinkage and selection operator (LASSO) penalty. Predictive performance was assessed using Harrell's C-index, time-dependent area under the receiver operating characteristic curve, continuous/categorical net reclassification improvement, and integrated discrimination improvement.

RESULTS
Over a median follow-up of 13.2 years, 157 incident PAD cases occurred. We observed 463 proteins associated with PAD risk, primarily involved in pathways related to signal transduction, inflammatory response, plasma membrane, protein binding, and cytokine-cytokine receptor interactions. Ranking by P values, the top five proteins associated with increased PAD risk included EDA2R, ADM, NPPB, CD302, and NPC2, while BCAN, UMOD, PLB1, CA6, and KLK3 were the top five proteins inversely associated with PAD risk. Incorporating 45 LASSO-selected proteins or a weighted protein risk score significantly enhanced PAD prediction beyond clinical variables alone, reaching a maximum C-index of 0.835.

CONCLUSIONS
This study identified plasma proteins associated with PAD risk in individuals with T2D. Adding proteomic data into the clinical model significantly improved PAD prediction.
Profesjonspraksis i møte med barnehagebarns fysiske aktivitet
Authors: Bjørgen Kathrine , Sivertsen Anne Holla , Kippe Karin 
Published: January 2025

Fra flere hold er det uttrykt bekymringer knyttet til samfunnsendringer som påvirker barns fysiske aktivitet negativt og kan føre til uhelse (se f.eks. Helsedirektoratet, 2019). Hvordan samfunnsendringer påvirker utøvelse av barnehagepersonalets profesjonelle praksis er lite dokumentert. Målet med denne studien var å undersøke barnehagelæreres erfaringer med profesjonspraksis i fagområdet fysisk aktivitet i barnehagen. I studien har vi gjennomført semistrukturerte intervjuer med ti barnehagelærere fra ti ulike barnehager i Midt-Norge. Funnene viser at praktisk profesjonskunnskap er avgjørende i arbeidet med fysisk aktivitet i barnehagen, og at ulike barnehager har ulike praksiser. Etter endt barnehagelærerutdanning oppgir informantene svak utvkling i fagområdet både akademisk og profesjonsmessig. De etterspør ledelseskompetanse som fremmer profesjonsforståelsen gjennom kollektive prosesser og kultur for betydningen av barns fysiske aktivitet. Kollektive prosesser kan bidra til felles forståelse og motivasjon i arbeidet med å fremme barns fysiske aktivitet. Både barnehagelærerutdanningene og praksisfeltet må være mer innovativ, tilpasningsdyktig og utviklingsorientert i samsvar med samfunnsutviklingen.
ENGLISH ABSTRACT
Professional Practice of the Subject Area of Physical Activity and Health in Early Childhood Education and Care (ECEC) Institutions
Concerns have been raised about societal changes that negatively impact children’s physical activity, potentially leading to ill health (Helsedirektoratet, 2019). However, little documentation exists on how these societal changes affect the professional practices of Early Childhood Education and Care (ECEC) teachers. This study aimed to explore ECEC teachers’ experiences with professional practice related to physical activity. Semi-structured interviews with ten ECEC teachers from ten different kindergartens in central Norway were included in this study. Findings indicate that practical professional knowledge is crucial for promoting physical activity and practices vary across different ECEC Institutions. The informants reported limited professional and academic development in this area after completing their studies. They expressed a need for greater competence in leading development that fosters professional understanding through collective processes and a culture that emphasizes the importance of children’s physical activity. Collective awareness could contribute to a common understanding and motivation to promote physical activity among children. Both kindergarten ECEC teacher training and the ECEC field of practice need to be adaptive and development-oriented to align with societal changes.
Pengaruh Substitusi Pupuk Organik Cair dan Media Tanam terhadap Pertumbuhan dan Produksi Kangkung (Ipomoea aquatica) dengan Sistem Hidroponik
Authors: Putri Rona Herlina Rahma , Purbajanti Endang Dwi , Fuskhah Eny 
Published: January 2025

The growth and production of hydroponic water spinach using liquid organic fertilizer and appropriate planting media determines the success of the plant. The aim of this research is to determine the effect of liquid organic fertilizer (LOF) substitution types and planting media on the growth of water spinach (Ipomoea reptans) production. Data collection was carried out in the month 23 Februaty – 30 March 2023 in Pudakpayung village, Banyumanik District, Semarang City. Treatments were arranged using a completely randomized design with 2 factors. Factor 1 is the planting medium in 2 level, M1 = Rockwool dan M2 = Cocopeat, and factor 2 is the substitution of liquid organic fertilizer in 4 levels, N1 = 4 ml/l AB mix, N2 = 3 ml/l AB mix + 2 ml/l POC, N3 = 2 ml/l AB mix + 3 ml/l POC, dan N4 = 4 ml/l POC. Each treatment was carried out in 3 repetitions so that there were 24 experimental units. The parameters observed were plant height, number of leaves, root length, shoot fresh weight, root weight, biomass weight, and leaf color. The data was analyzed for variance and further tested using the honest real difference (BNJ) at the 5% level. The research results showed that the use of LOF of rice waste and papaya fruit could substitute AB mix at a concertation of 2 ml/l AB mix + 3 ml/l LOF or 50%. However, the use of 100% POC cannot replace AB mix in growth and production of water spinach. Keywords : AB mix, cocopeat, liquid fertilizer, rockwool, rice, papaya fruit, waste
Perlakuan Lama Simpan dan Macam Pembungkus Entres Mangga (Mangifera indica L.) terhadap Pertumbuhan Bibit Sambung Pucuk
Authors: Putri Aura Nabita , Kusumaningrum Nora Augustien , Nugrahani Pangesti 
Published: January 2025

Mango (Mangifera indica L.) can be developed through plant propagation by the method of shoot-tip grafting. The problem that often take place is the distance between the mother tree and the location of the connection that is far apart, so it takes a long time and is tough to finish within one day. This research aims to obtain a combination of shelf life and types of scion wrapping materials on the growth of mango seedlings. The research conducted in April - August 2023 at UPT Horticultural Seed Development using Complete Randomized Design (CRD) with 2 factors 3 replications. The first factor is storage time (L) (0 days, 2 days, 4 days, and 6 days) and the second factor is the type of wrapping materials (M) (without packaging, banana frond wrapping, newspaper wrapping, and coconut husk wrapping). Parameters include the time at which shoots appear, the percentage of viable grafting, the length of the shoots and the total number of leaves. The results showed that in general the percentage of success was 70%. The treatment of storage time and type of entres wrapper did not affect the percentage of live grafting, but at a storage time of 2 days, the fastest results were obtained at the time of bud emergence and the longest results in bud length. Keywords: Entry, Length of Storage, Type of Wrapping, Mango Shoot Grafting
Tingkat Ketuaan Bahan Setek dan Konsentrasi IAA pada Pertumbuhan Setek Lada
Authors: Sugiatno Sugiatno , Nurmauli Niar , Susanto Herry 
Published: January 2025

Pepper plant propagation generally uses stem cuttings. Choosing the maturity level of the cutting will determine the subsequent growth of the cutting, because the body parts of the plant contain different food reserves and endogenous auxin. The growth regulator Indole Acetic Acid is used to stimulate the growth of roots and shoots of cuttings. The research aims to determine the effect of the level of maturity of the cutting material and IAA concentration on the growth of pepper seedlings and to determine the effect of the interaction between the two treatments. Research was carried out in the Greenhouse and Plant Science Laboratory, Faculty of Agriculture, University of Lampung. The experimental design used a completely randomized design (RTS), homogeneity was tested with the Bartlett test, non-additivity was tested with the Tukey test. Analysis of variance and least significant difference test (LSL) were carried out at the 5% level. The research results concluded (1). Cuttings originating from the middle part grew faster, namely in sprouting shoots, length of cutting shoots, number of leaves, and dry weight, but there was no significant difference in the dry weight of cutting roots. (2). An IAA concentration of 500 ppm gave the best response to shoot sprouting, shoot length of cuttings, number of leaves, and root dry weight. (3). Cuttings originating from the middle section that were applied with IAA 500 ppm were the best combination in terms of shoot emergence, shoot length, number of leaves, and shoot dry weight. Key words: cuttings, indole acetic acid, black pepper