bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifestyle and psychosocial correlates of oral hygiene practice among Indonesian adolescents
Authors: Santoso Cornelia Melinda Adi , Bramantoro Taufan , Nguyen Minh Chau , Nagy Attila 
Published: January 2021

AbstractPoor oral hygiene leads to poor oral health, which in turn has negative impacts on overall health and quality of life. This study aimed to evaluate the prevalence and associated factors of oral hygiene practice among school‐going adolescents in Indonesia. Secondary analysis of cross‐sectional, nationally representative data from the 2015 Indonesia Global School‐based Health Survey, covering 11,142 students aged 11‐18 years, was performed. Multiple logistic regression was employed to explore associations between lifestyle, psychosocial factors, and tooth‐brushing frequency. Around 10.8% of the students brushed their teeth less frequently than the recommended twice‐daily regimen. Male gender, lower socio‐economic status, poor dietary practice, longer sedentary time, drug use, psychological distress, less peer support, and no parental support were associated with infrequent tooth brushing. The findings support the need to integrate oral health promotion into general health actions that target families, schools, and social environments of adolescents to develop healthier habits.
Approaches to energy transitions: Carbon pricing, managed decline, and/or green new deal?
Authors: Eaton Emily 
Published: January 2021

AbstractThe need for wholescale energy transitions across the globe is now clear, but there is still much debate about how best to achieve carbon neutrality by 2050. Carbon‐pricing has so far been unable to avert the coming climate catastrophe. Instead supply‐side, managed decline of the fossil fuel sector and proposals for Green New Deals, or Just Transition are gaining steam among academics, policy communities, and movements and even entering mainstream politics. In this article, I review three main approaches to energy transition and highlight their underlying goals and assumptions. I argue that movements for energy transition must center social and economic justice in their struggles if they want to gain broad‐based appeal.
Cognitive performance in patients with episodic cluster headache outside and inside the active cluster
Authors: Navarro‐Pérez María Pilar , Bellosta‐Diago Elena , Viloria‐Alebesque Alejandro , Garrido‐Fernández Alberto , López‐Bravo Alba , Santos‐Lasaosa Sonia 
Published: January 2021

AbstractBackgroundPrevious studies have shown worse cognitive performance in cluster headache (CH) patients compared to healthy controls; however, little is known about cognitive performance in episodic CH (ECH) patients outside and inside the active cluster (AC).ObjectiveOur aim is to compare cognitive function in ECH patients outside and inside the AC.MethodsIn this cross‐sectional, observational study, four neuropsychological tests (Trail Making Test [TMT], Stroop Test [ST], verbal fluency [VF], and Symbol Digit Modalities Test [SDT]) were completed by 21 ECH patients at two different points in time: outside and inside the AC. We also assessed self‐reported sleep quality and the presence of anxiety or depressive symptoms. Scores were compared.ResultsThere was not any difference between the scores of the neuropsychological tests performed outside and inside the AC (TMT‐A: 23 vs. 23.5; p = 0.984; TMT‐B: 96.5 vs. 85.9; p = 0.104; ST word reading: 101.0 vs. 101.2; p = 0.938; ST color naming: 73.0 vs. 73.4; p = 0.858; ST color word: 44.0 vs. 46.0; p = 0.498; SDMT: 44.0 vs. 44.6; p = 0.961; VF phonemic: 29.5 vs. 30.2; p = 0.714; VF semantic: 20 vs. 21; p = 0.489). We found a worsening in the sleep quality component of the Pittsburgh Sleep Quality Index median scores in patients outside the AC (2 vs. 1; p = 0.046).ConclusionsOur findings suggest that patients with ECH have a similar cognitive performance outside and during the AC.
Psychometric characteristics of the health care empowerment questionnaire in a sample of patients with arthritis and rheumatic conditions
Authors: Knight Erin , Carluzzo Kathleen , Schifferdecker Karen E. , Creek Emily , Butcher Rebecca L , Eakin Guy S. 
Published: January 2021

AbstractBackgroundPatient empowerment can improve health‐related outcomes and is important in chronic conditions, such as arthritis. This study aimed to validate the Health Care Empowerment Questionnaire (HCEQ), a patient‐reported experience measure of empowerment, for use with patients with arthritis and other rheumatic diseases.MethodsThe HCEQ measures Patient Information Seeking (or Involvement in Decisions) and Healthcare Interaction Results (or Involvement in Interactions) and asks respondents to answer questions in two ways: whether they feel something happened and its importance to them. Face validity was assessed through qualitative data (n = 8, nominal group technique; n = 55, focus groups). Measure structure was assessed through confirmatory factor analysis (CFA); internal consistency was also assessed (n = 9226). Test‐retest reliability was assessed with sub‐sample of participants (n = 182).ResultsWe found adequate face validity of the HCEQ for patients with arthritis. The CFA indicated good fit to the data for the two‐factor structure of the HCEQ (RMSEA = 0.075; CFI = 0.987; TLI = 0.978; SRMR = 0.026). Internal consistency was strong (α=0.94 for both subscales). Test‐retest reliability was moderate for Patient Information Seeking (ICC=0.67) and good for Healthcare Interaction Results (ICC=0.77).ConclusionsThe HCEQ, with modifications, demonstrated promising psychometric properties within this sample, laying the foundation for further assessment. This work supports the HCEQ as an appropriate instrument for examining experiences with and perceived importance of empowerment in individuals with arthritis and other rheumatic conditions.Patient ContributionPatients contributed to the assessment of face validity. As a measure of patient empowerment, the HCEQ’s use can enable further participation of patients in health care.
Alterations of mitochondrial dynamics, inflammation and mineralization potential of lipopolysaccharide‐induced human dental pulp cells after exposure to N‐acetyl cysteine, Biodentine or ProRoot MTA
Authors: Weekate K. , Chuenjitkuntaworn B. , Chuveera P. , Vaseenon S. , Chompu‐inwai P. , Ittichaicharoen J. , Chattipakorn S. , Srisuwan T. 
Published: January 2021

AbstractAimTo investigate the effects of N‐acetyl cysteine (NAC), Biodentine, ProRoot MTA and their combinations, on cell viability, mitochondrial reactive oxygen species (mtROS) production, mineralization and on the expression of genes related to inflammatory cytokine production, mitochondrial dynamics and cell apoptosis of lipopolysaccharide (LPS)‐induced human dental pulp cells (hDPCs).MethodologyIsolated hDPCs were exposed to 20 μg mL−1 of Escherichia coli (E. coli) LPS for 24 h, before the experiment, except for the control group. Eight experimental groups were assigned: (i) control (hDPCs cultured in regular medium), (ii) +LPS (hDPCs cultured in LPS medium throughout the experiment), (iii) −LPS/Media, (iv) −LPS/BD, (v) −LPS/MTA, (vi) −LPS/NAC, (vii) −LPS/BD + NAC and (viii) −LPS/MTA + NAC. Cell viability was measured using Alamar blue assay at 24 and 48 h. Production of mtROS was evaluated at 6 and 24 h by MitoSOX Red and MitoTracker Green. The expressions of IL‐6, TNF‐α, Bcl‐2, Bax, Mfn‐2 and Drp‐1 genes were investigated at 6 h using reverse transcriptase‐polymerase chain reaction (RT‐PCR). For differentiation potential, cells were cultured in the osteogenic differentiation media and stained using Alizarin red assay at 14 and 21 days. The Kruskal–Wallis test, Mann–Whitney U test and one‐way anova were performed for statistical analysis.ResultsNAC was associated with significantly greater LPS‐induced hDPC viability (P < 0.05). Both Biodentine and MTA extracts promoted cell survival, whereas the combination of NAC to these material extracts significantly increased the number of viable cells at 24 h (P < 0.05). Biodentine, MTA or NAC did not alter the mtROS level (P > 0.05). NAC supplementation to the MTA extract significantly reduced the level of IL‐6 and TNF‐α expression (P < 0.05). Regarding mitochondrial dynamics, the use of NAC alone promoted significant Mfn‐2/Drp‐1 expression (P < 0.05). Most of the groups exhibited a level of Bcl‐2/Bax gene expression similar to that of the control group. The increases in mineralization productions were observed in most of the groups, except the LPS group (P < 0.05).ConclusionsThe antioxidant effect of NAC was not evident under the LPS‐induced condition in DPC in vitro. NAC combined either with Biodentine or MTA improved LPS‐induced hDPCs survival at 24 h. The combination of NAC with MTA promoted mineralization.
Megakaryocytes, erythropoietic and granulopoietic cells express CAL2 antibody in myeloproliferative neoplasms carrying CALR gene mutations
Authors: Ali Hebah , Puccio Ignazio , Akarca Ayse U. , Bob Roshanak , Pomplun Sabine , Keong Wong Wai , Gupta Rajeev , Sekhar Mallika , Lambert Jonathan , Al‐Masri Hytham , Stein Harald , Marafioti Teresa 
Published: January 2021

AbstractTesting for the CALR mutation is included in the updated WHO criteria for essential thrombocythaemia (ET) and primary myelofibrosis (PMF). We report on the application of the CAL2 monoclonal antibody, raised against the mutated CALR gene to myeloid cases. The immunostain was used on 116 acute myeloid leukaemias (AML) and 66 myeloproliferative neoplasms (MPN) or myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN). None of AML cases was stained by the CAL2 antibody, while 20/66 MPNs and MDS/MPNs appeared positive. Fourteen of the latter cases were studied by molecular techniques, and all showed aberrations of the CALR gene. In addition, CAL2 positivity was found in some small‐sized elements besides megakaryocytes. By double staining, these elements corresponded to small megakaryocytes as well as both erythroid and myeloid precursors. This finding suggests possible occurrence of CALR gene abnormalities in a stem cell.
Evaluation of sourcing contracts in wood supply procurement using simulation
Authors: Rahimi Ali , Rönnqvist Mikael , LeBel Luc , Audy Jean‐François 
Published: January 2021

AbstractProcurement operations in forest companies are exposed to various risks, which may increase procurement costs. Examples of risks are the contract's unreliability and contract breach. Deterministic planning models cannot perfectly reflect the complexities of real‐world applications in the presence of sourcing risks when the future is uncertain. In practice, forest industries use contracts to guarantee the wood supply. Monthly forecasts are prepared for the delivery volume and are primarily based on the experience of procurement staff and the total volume of contracts. Missed deliveries in the contracts lead to a mismatch between the supply and demand for wood fiber and increase the costs of procurement as a result of high inventory costs or expensive purchases from the open market. Previous studies on simulating the impact of sourcing risks on procurement operations have been conducted; however, none have addressed the selection of procurement contracts in the presence of sourcing risks. In forest industry, numerous suppliers are available with sourcing contracts. Each contract possesses its own characteristics such as flexibility, volume, schedule, and price of delivery. A Monte Carlo simulation approach is implemented to analyze the behavior of a deterministic planning approach. Random events are generated by formulating different types of sourcing risks, having either short‐ or long‐term impact. The simulation is embedded with a deterministic planning model in each period. Results showed that management of sourcing risks is easier with flexible contracts than with fixed contracts, despite their higher purchasing cost.
Homecare nurses guide goals for care and care transitions in serious illness: A grounded theory of relationship‐based care
Authors: Sullivan Suzanne S. , Mann Catherine , Mullen Samantha , Chang Yu‐Ping 
Published: January 2021

AbstractAimsTo identify the process that homecare nurses use when recognizing serious illness, engaging patients and families in goals‐for‐care discussions and guiding transitions to comfort‐focused care.DesignConstructivist grounded theory.MethodsSemi‐structured focus group interviews of 31 homecare Registered Nurses were recorded and transcribed (June–August 2019). Line‐by‐line coding using the constant comparative method until saturation was achieved and a grounded theory was identified. Credibility, transferability, and confirmability establish study rigor.ResultsA grounded theory of relationship‐based care. Nurses cogitate and act when recognizing serious illness. They have difficult conversations and support care transitions with wisdom and knowing, by identifying changes in illness trajectories and being informed and alert to diminishing quality of life. Nurses are skilled at engaging patients, families, and the team and accommodate care in the home for as long as possible, while manoeuvring through complex systems of care; ultimately relinquishing and guiding care to other providers and settings. However, nurses feel inadequately prepared and frustrated with a fragmented healthcare system and lack of collaboration among the team.ConclusionThis study identifies a grounded theory to support clinical decision‐making and position homecare nurses as leaders in guiding goal care discussions and transitions to comfort‐focused care. These findings reinforce the importance of developing health policy that ensures care continuity in serious illness. Further research is needed to improve relationships across care settings and enhance training for the delivery of comfort‐focused care in the home as changing needs emerge during serious illness management.
Serum folate and vitamin B12 levels in cutaneous melanoma
Authors: Tas Faruk , Erturk Kayhan , Soydinc Hilal Oguz 
Published: January 2021

AbstractBackgroundVitamin B12 and folate are the major micronutrients that play significant roles in DNA synthesis. Epidemiological studies and clinical evidences displayed alterations in serum concentrations folate and of vitamin B12 in various human malignancies, yet their roles in patients with melanoma have yet to be understood.ObjectiveTo assess circulating vitamin B12 and folate concentrations of patients with melanoma and compare them with other malignant tumors and healthy subjects.MethodsA total of 98 skin melanoma cases from university clinic were enrolled into the study. Serum vitamin B12 and folate concentrations were analyzed by electrochemiluminescence binding assay.ResultsCirculating levels of vitamin B12 in patients with melanoma were similar compared with other malignancies and healthy controls (P > .05). However, melanoma cases had significantly lower serum folate concentrations than healthy control group (P = .04). Melanoma patients with metastatic disease (P = .001) and with short history of disease (P = .05), and those who had active diseases in course of the study (P = .04) had low serum folate concentrations.ConclusionSerum levels of folate were found significantly lower in melanoma cases, and this association was stronger for patients with metastatic melanoma; however, no such association was found between melanoma and serum vitamin B12 levels.
A novel classification of glucose profile in pregnancy based on continuous glucose monitoring data
Authors: Inayama Yoshihide , Yamanoi Koji , Shitanaka Shimpei , Ogura Jumpei , Ohara Tsutomu , Sakai Mie , Suzuki Haruka , Kishimoto Ichiro , Tsunenari Toru , Suginami Koh 
Published: January 2021

AbstractAimTo investigate the glucose profile of women with and without gestational diabetes mellitus (GDM) by simultaneously analyzing several factors of continuous glucose monitoring (CGM) data.MethodsCGM was conducted for 2 weeks in the second trimester of pregnant women whose random blood glucose level was ≥100 mg/dl. A 75‐g oral glucose tolerance test was performed around day 7, and the index of hyperglycemia, relative hypoglycemia, and indices of glucose variability were extracted from CGM data. Unsupervised hierarchical clustering was performed to categorize glucose profiles of the participants.ResultsCGM data were obtained from 29 women. Glucose profiles were categorized into three clusters: low glucose levels with less glucose variability group (L group, n = 7); moderate glucose levels with moderate‐to‐high glucose variability group (M group, n = 18); and high glucose levels with high glucose variability group (H group, n = 4). The waveforms of the glucose profiles were very different among the three groups. Women with GDM tended to be more frequent in the H group than in the M and L groups (75.0%, 16.7%, and 14.3%, respectively; p = 0.053). Maternal age was significantly higher and the proportion of multiparous women was significantly larger in the H group compared to L group (p = 0.002 and 0.015, respectively).ConclusionsA comprehensive analysis of CGM data could help us extract a subgroup of women with characteristics of GDM.
Hypersensitivity reaction to pegylated liposomal doxorubicin administration for Mullerian carcinoma in Japanese women
Authors: Yamaguchi Shinichiro , Yahata Hideaki , Okugawa Kaoru , Kodama Keisuke , Yagi Hiroshi , Yasunaga Masafumi , Ohgami Tatsuhiro , Onoyama Ichiro , Asanoma Kazuo , Kato Kiyoko 
Published: January 2021

AbstractAimPEGylated liposomal doxorubicin (PLD) is a therapeutic agent for gynecological malignancy. Hypersensitivity reaction (HSR) is a major adverse effect that usually disappears after halting administration of PLD. Premedication is usually not necessary before administration of PLD to prevent HSR. Here, we evaluated the frequency of HSR during administration of PLD following premedication in Japanese women.MethodsWe performed PLD administration in 78 patients (386 cycles) between 2013 and 2018. Granisetron hydrochloride and dexamethasone sodium phosphate were administered 30 min before PLD administration. Then, PLD (40 or 30 mg/m2 combined usage with carboplatin) was administered. We retrospectively reviewed the medical records of 78 patients and examined the frequency of HSR.ResultsSeven of 78 (9%) patients showed HSR by PLD administration following premedication. One patient showed cardiopulmonary arrest in 13 min after PLD administration (grade 4). The other six patients showed grade 2 HSR. All patients developed HSR in the first course. The incidence of HSR was significantly higher in patients with allergic history than in patients without allergic history (p = 0.0151).ConclusionsClinicians should be aware of the potential for HSR in patients administered PLD, particularly those with allergic history and those receiving the first cycle of PLD, even following premedication.
Eighteenth‐century theater history and performance studies
Authors: Wessel Jane 
Published: January 2021

AbstractOver the last few decades, theater history has moved beyond a documentary and descriptive approach to become a field that increasingly embraces the “epistemological uncertainty” that comes with studying an unfixed medium. This shift owes much to the flourishing of performance studies in the 1990s and 2000s. This essay examines the effects of performance studies on 18th‐century theater history. Theater historians of earlier periods have long grappled with how to study a medium that is uncapturable by print alone. Performance's ephemerality and its embodiment, in particular, pose challenges to those working in the archives. This essay reviews the recent scholarship that brings together the archival work of theater history with newer performance‐oriented methodologies. The turn to performance studies allows us to better theorize the experiences and identities that archives have sometimes obscured, especially involving women and minorities. Moreover, taking the medium of performance seriously not just as an object of study, but as a mode of constructing and disseminating theater history enables us to experience vicariously sensory elements of performance that traditional print scholarship cannot fully capture.
Differential expression analysis of urinary exosomal circular RNAs in patients with IgA nephropathy
Authors: Luan Rumei , Tian Geng , Ci Xin , Zheng Qian , Wu Linlin , Lu Xuehong 
Published: January 2021

AbstractAimsImmunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease to cause end‐stage kidney disease. This study investigated the difference in urinary exosomal circular RNA (circRNA) expression profiles between patients with IgAN and healthy controls (HCs), for better understanding of gene regulation in exosomes of IgAN patients.MethodsA pairwise comparison of urinary circRNA expression profiles between IgAN patients and HCs was performed using methods, including high‐throughput sequencing and quantitative polymerase chain reaction. Moreover, the potential functions of differentially expressed circRNAs (DECs) in IgAN were investigated by gene ontology (GO) enrichment analysis; Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis; and the circRNA‐miRNA‐mRNA network.ResultsWe identified 450 upregulated and 26 downregulated circRNAs in the IgAN patients. GO analysis showed that these enriched circRNAs might regulate primary miRNA processing, the ability of angiotensin receptor binding, and stress fibre function. KEGG analysis suggested these DECs may be closely associated with the phosphoinositide‐3‐kinase‐protein kinase B/Akt (PI3K‐Akt) signalling pathways. Network analysis revealed the relationship between circRNAs and their target genes.ConclusionThe identified DECs may be useful for both researches on molecular aetiology of IgAN and development of potentially novel non‐invasive biomarkers of IgAN.
Shy Girl, a kiwifruit suppressor of feminization, restricts gynoecium development via regulation of cytokinin metabolism and signalling
Authors: Varkonyi‐Gasic Erika , Wang Tianchi , Cooney Janine , Jeon Subin , Voogd Charlotte , Douglas Mikaela J. , Pilkington Sarah M. , Akagi Takashi , Allan Andrew C. 
Published: January 2021

Summary

Kiwifruit (Actinidia chinensis) is a dioecious, long‐living woody perennial vine. Reduced generation time and induction of hermaphroditism can accelerate crop improvement and facilitate alternative farming for better food security in the face of climate change.

Previous studies identified that CENTRORADIALIS genes CEN and CEN4 act to repress flowering, whilst the male‐specific Shy Girl (SyGl) gene with homology to type‐C cytokinin response regulators could repress gynoecium development in model plants. Here we use CRISPR/Cas9 to mutagenize CEN, CEN4 and SyGl in the male kiwifruit A. chinensis ‘Bruce’.

Biallelic mutations of CEN and CEN4 generated rapid‐flowering male plants, and simultaneous targeting of CEN4 and SyGl gave rise to rapid‐flowering hermaphrodites with restored gynoecial function and viable pollen, providing functional evidence for the role of SyGl in suppression of feminization. Analysis of ovary tissues identified genes that contribute to carpel development and revealed that SyGl affected both cytokinin profiles and the expression of genes involved in cytokinin metabolism and signalling. The plant lines generated by CEN4/SyGl knockout could self‐pollinate and produce fast‐flowering offspring.

These results establish that SyGI acts as the suppressor of feminization in kiwifruit and demonstrate the potential for accelerated breeding in an outcrossing horticultural woody perennial.