bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical abnormalities in COVID-19: a comparison of white versus ethnic minority populations in the UK
Authors: Taylor David R , Buchanan Devon , Al-Hasani Wiaam , Kearney Jessica , Mazaheri Tina , Ranasinghe Ruvini N K , Dimitriadis Georgios K , Vincent Royce P 
Published: May 2021

AimsPublic Health England has identified that in COVID-19, death rates among ethnic minorities far exceeds that of the white population. While the increase in ethnic minorities is likely to be multifactorial, to date, no studies have looked to see whether values for routine clinical biochemistry parameters differ between ethnic minority and white individuals.MethodsBaseline biochemical data for 22 common tests from 311 SARS-CoV-2 positive patients presenting to hospital in April 2020 in whom ethnicity data were available was retrospectively collected and evaluated. Data comparisons between ethnic minority and white groups were made for all patient data and for the subset of patients subsequently admitted to intensive care.ResultsWhen all patient data were considered, the ethnic minority population had statistically significant higher concentrations of C reactive protein (CRP), aspartate aminotransferase and gamma-glutamyl transferase, while troponin T was higher in the white group. A greater proportion of ethnic minority patients were subsequently admitted to intensive care, but when the presenting biochemistry of this subset of patients was compared, no significant differences were observed between ethnic minority and white groups.ConclusionOur data show for the first time that routine biochemistry at hospital presentation in COVID-19 differs between ethnic minority and white groups. Among the markers identified, CRP was significantly higher in the ethnic minority group pointing towards an increased tendency for severe inflammation in this group.
Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult
Authors: Chen Ding Bao , Liu Xiao Yang , Kong Fang Zhou , Jiang Qian , Shen Dan Hua 
Published: May 2021

To describe the clincopathological features and evaluate risk factors of post-transplant lymphoproliferative disorder (PTLD) after allogeneic haematopoietic stem cell transplants (allo-HSCT), with comparison between paediatric and adult .Clinicopathological features of 81 cases of PTLD after allo-HSCT were analysed by histopatholgy, immunohistochemistry and in situ hybridisatioin.The cases included 58 males and 23 females with a median age of 26.7 years (range 6–55 years) and the PTLDs developed 1–60 months post-transplant (mean 5.9 months). The histological types indicated 10 cases of non-destructive PTLD, including 4 of plasmacytic hyperplasia, 5 of infectious mononucleosis and 1 of florid follicular hyperplasia. Fifty-six cases were polymorphic PTLD, and 15 were monomorphic PTLD, including thirteen of diffuse large B cell lymphoma, 1 of extranodal nasal type natural killer (NK)/T cell lymphoma and 1 of plasmablastic lymphoma. Foci and sheets of necrosis were observed in 31 cases. The infected ratio of Epstein-Barr virus (EBV) was 91.4%. Some cases were treated by reduction of immunosuppression, antiviral therapy, donor lymphocyte infusion or anti-CD20 monoclonal rituximab. Thirty-three cases died. Compared with that of adult, overall survival of paediatric recipient may be better.The first half year after allo-HSCT is very important for the development of PTLD. Type of PTLD, EBV infection and graft-versus-host disease are risk factors. The prognosis of PTLD is poor, and PTLD after allo-HSCT exhibits some features different from that after solid organ transplantation and some differences existing between adult and paediatric recipients.
Influence of halo single-neutron transfer on near barrier $$^{15}$$C + $$^{12}$$C total fusion
Authors: Keeley N. , Kemper K. W. , Rusek K. 
Published: May 2021

AbstractA recent comparison of the average fusion cross section, $$\left\langle \sigma _\mathrm {F}\right\rangle $$

σ
F

, for energies just above the Coulomb barrier for the $$^{12-15}$$

12
-
15

C + $$^{12}$$

12

C systems found that the behaviour as a function of projectile neutron excess could not be satisfactorily explained by static barrier penetration model calculations and suggested that the neutron dynamics plays an important rôle. In this work we demonstrate that the ($$^{15}$$

15

C,$$^{14}$$

14

C) single neutron transfer has a significant influence on the above barrier $$^{15}$$

15

C + $$^{12}$$

12

C total fusion, although not quite in the way expected since it leads to a reduction in the cross section, contrary to the trend in the measured $$\left\langle \sigma _\mathrm {F}\right\rangle $$

σ
F

. However, this result underlines the danger of ignoring the effect of neutron transfer reactions on fusion in systems involving neutron halo nuclei.
Seroprevalence and Public Health Significance of Toxoplasmosis in Small Ruminants of Pastoral Community in Yabello District, Borana Zone, Southern Ethiopia
Authors: Jilo Kula , Tegegne Dechassa , Kasim Sadik , Dabasa Golo , Zewdei Wubishet 
Published: May 2021

Toxoplasmosis is a zoonotic protozoan disease. Data on seroepidemiology of toxoplasmosis in Ethiopia is scarce, almost null in the pastoral area of the Borana zone. The study was carried out to determine the seroprevalence, to identify risk factors of toxoplasmosis in sheep and goats, and to assess the awareness level of pastoralists about toxoplasmosis in the Yabello district of Borana zone, Southern Ethiopia. A cross-sectional study was conducted from November 2016 to April 2017 in six peasant associations of the Yabello district of Borana zone, Southern Ethiopia. A total of 400 serum samples of randomly selected small ruminants owned by pastoralists were examined to detect antibodies specific to Toxoplasma gondii using Latex Agglutination Test (SPINREACT, Girona, Spain). A semistructured questionnaire survey was used to conduct a face-to-face interview with owners (n = 100) of sampled flocks. Logistic regression analysis was used to determine the association of hypothesized risk factors. The overall seroprevalence was 52.8% of which 57.8 and 47.8% were sheep and goats, respectively. Univariate logistic regression analysis revealed a higher seroprevalence ratio of T. gondii infection in sheep than goats (COR: 1.95, 95% CI: 1.226–3.112;

P

= 0.005). Multivariate logistic regression analysis indicated significantly higher odds of acquiring T. gondii infection in adult animals (sheep: (AOR = 2.26, 95% CI: 1.323–3.874;

P

= 0.003), goats: (AOR = 2.15; 95% CI: 1.009–4.579;

P

= 0.047)), female sheep (AOR = 2.45; CI: 1.313–4.568;

P

= 0.005), animals from lowland areas (sheep: (AOR = 2.28; CI: 1.190–4.356;

P

= 0.013), goat: (AOR = 3.27; CI: 1.386–7.723;

P

= 0.007)), animal drinking lake water (sheep: (AOR = 1.93; CI: 1.011–3.698;

P

= 0.046), goat: (AOR = 2.96; CI: 1.297–6.771;

P

= 0.010)), and goats with history of abortion (AOR = 2.42; CI: 1.242–4.711;

P

= 0.009) than young animals, male (sheep), animals from midland areas, animals drinking wells water, and flock with no history of abortion (goat), respectively. Among respondents, 97.0% had no knowledge about toxoplasmosis and 75.0% drink raw milk and consume the meat of sheep and goats. 80.0% of respondents had no knowledge about the risk of cats to human and animal health while 70.0% of them had domestic cats and practice improper fetal body handling. Highly prevailing toxoplasmosis in small ruminants of the Yabello district might pose a serious economic loss and be a potential public health threat to the extremely vulnerable pastoralists. Therefore, awareness and further studies are warranted to tackle the economic and public health consequences of T. gondii infection.
Thick cuticles as an anti-predator defence in nematodes
Authors: Ichiishi Kanata , Ekino Taisuke , Kanzaki Natsumi , Shinya Ryoji 
Published: May 2021

Summary
Although some anti-predator defences have been documented in nematodes, the role of the cuticle in defending against predator attacks remains unclear. Microscopical observations have suggested that certain Poikilolaimus species, including P. oxycercus and P. regenfussi, have thick cuticles relative to their congeners, which may represent an anti-predator defence, but the role of the cuticle in reducing predation has not been examined. To address this knowledge gap, we first quantified cuticle structure using transmission electron microscopy among four Poikilolaimus species (P. oxycercus, P. regenfussi, P. floridensis and P. carsiops). We then examined their survival rates following exposure to the predatory aphelenchoidid nematode, Seinura caverna, and assessed correlations between cuticle thickness and survival rate. The cuticles of P. oxycercus and P. regenfussi were significantly thicker than those of P. floridensis and P. carsiops. In addition, P. oxycercus and P. regenfussi had an osmophilic zone in their cuticle structure, which was not observed in P. floridensis and P. carsiops. Both thickness of specific cuticle zones and total cuticle thickness were positively correlated with survival in the presence of a predator, with the strongest correlation observed with the thickness of the osmophilic zone. We suggest that P. oxycercus and P. regenfussi have uniquely evolved cuticles among members of Poikilolaimus in terms of thickness and structure that play an important role in reducing predation.
Ilyenkov’s Dialectics of the Ideal and Engels’s Dialectics of Nature
Authors: Piedra Arencibia Rogney 
Published: May 2021

Abstract
Within the current resurgence of interest in E.V. Ilyenkov, the influence of Engels on Ilyenkov’s work is either overlooked or denied, making Ilyenkov seem closer to Western Marxism than he actually is. In this paper, by considering Engels’s place in his philosophy, I show that Ilyenkov’s approach is fundamentally hostile to many of Western Marxism’s main views. Ilyenkov, like Engels, conceives philosophy as Logic and affirms the ‘alliance’ between philosophy and the natural sciences against speculative metaphysics. In this regard, he develops an original cosmological hypothesis based on Engels’s insights on the hierarchy of matter’s forms of movement and provides a remarkable account of the ideal as an attribute of nature that reproduces its concrete universality through social labour, the active transformation of nature’s phenomena into objects stamped with the seal of our subjectivity.
Fossil woods from the Eocene of Corcovado, Argentinean Patagonia: geological setting and conifer diversity
Authors: Pujana Roberto R. , Aramendía Inés , García Massini Juan L. , Noetinger Sol 
Published: May 2021

Abstract
Eocene paleofloras of Patagonia are diverse and increasingly known. A new assemblage of fossil wood has been recovered from Eocene sediments in Corcovado, western Argentinean Patagonia. The lithological succession (formerly Arroyo Lyn Formation sensu Pesce 1979) is correlated with the Huitrera Formation. The specimens were mostly found embedded in sandstones and conglomerates. One-third of the assemblage are conifers and studied herein. We found four taxonomic types: Agathoxylon cf. antarcticum (Araucariaceae), Phyllocladoxylon antarcticum (Podocarpaceae), Podocarpoxylon dusenii (Podocarpaceae), and Cupressinoxylon hallei (Cupressaceae or Podocarpaceae). The presence of four taxonomic units among only 7 specimens suggests a significant conifer species richness in the assemblage. Araucariaceae and dominant Podocarpaceae are usually found in previously described conifer wood assemblages from the Eocene of Patagonia andAntarctica. The diversity of the conifer assemblage in Corcovado is very similar to that found at Laguna del Hunco (these two localities are 170 km distant), also from the Huitrera Formation. This is consistent with the proposal that the bearing sediments of both localities are from the same stratigraphic unit.
Scale-Dependent Value of QPF for Real-Time Streamflow Forecasting
Authors: Ghimire Ganesh R. , Krajewski Witold F. , Quintero Felipe 
Published: May 2021

AbstractIncorporating rainfall forecasts into a real-time streamflow forecasting system extends the forecast lead time. Since quantitative precipitation forecasts (QPFs) are subject to substantial uncertainties, questions arise on the trade-off between the time horizon of the QPF and the accuracy of the streamflow forecasts. This study explores the problem systematically, exploring the uncertainties associated with QPFs and their hydrologic predictability. The focus is on scale dependence of the trade-off between the QPF time horizon, basin-scale, space-time scale of the QPF, and streamflow forecasting accuracy. To address this question, the study first performs a comprehensive independent evaluation of the QPFs at 140 U.S. Geological Survey (USGS) monitored basins with a wide range of spatial scales (~10 – 40,000 km2) over the state of Iowa in the Midwestern United States. The study uses High-Resolution Rapid Refresh (HRRR) and Global Forecasting System (GFS) QPFs for short and medium-range forecasts, respectively. Using Multi-Radar Multi-Sensor (MRMS) quantitative precipitation estimate (QPE) as a reference, the results show that the rainfall-to-rainfall QPF errors are scale-dependent. The results from the hydrologic forecasting experiment show that both QPFs illustrate clear value for real-time streamflow forecasting at longer lead times in the short- to medium-range relative to the no-rain streamflow forecast. The value of QPFs for streamflow forecasting is particularly apparent for basin sizes below 1,000 km2. The space-time scale, or reference time (tr) (ratio of forecast lead time to basin travel time) ~ 1 depicts the largest streamflow forecasting skill with a systematic decrease in forecasting accuracy for tr > 1.
An idealized modeling study of the mid-latitude variability of the wind-driven meridional overturning circulation
Authors: Spall Michael A. 
Published: May 2021

AbstractThe frequency and latitudinal dependence of the mid-latitude wind-driven meridional overturning circulation (MOC) is studied using theory and linear and nonlinear applications of a quasi-geostrophic numerical model. Wind-forcing is varied by either changing the strength of the wind or by shifting the meridional location of the wind stress curl pattern. At forcing periods less than the first mode baroclinic Rossby wave basin crossing time scale the linear response in the mid-depth and deep ocean is in phase and opposite to the Ekman transport. For forcing periods close to the Rossby wave basin crossing time scale, the upper and deep MOC are enhanced, and the mid-depth MOC becomes phase shifted, relative to the Ekman transport. At longer forcing periods the deep MOC weakens and the mid-depth MOC increases, but eventually for long enough forcing periods (decadal) the entire wind-driven MOC spins down. Nonlinearities and mesoscale eddies are found to be important in two ways. First, baroclinic instability causes the mid-depth MOC to weaken, lose correlation with the Ekman transport, and lose correlation with the MOC in the opposite gyre. Second, eddy thickness fluxes extend the MOC beyond the latitudes of direct wind forcing. These results are consistent with several recent studies describing the four-dimensional structure of the MOC in the North Atlantic.
Developing and Validating a Computer-Based Training Tool for Inferring 2D Cross-Sections of Complex 3D Structures
Authors: Sanandaji Anahita , Grimm Cindy , West Ruth , Sanchez Christopher A. 
Published: May 2021

Objective Developing and validating a novel domain-agnostic, computer-based training tool for enhancing 2D cross-section understanding of complex 3D structures. Background Understanding 2D cross-sections of 3D structures is a crucial skill in many disciplines, from geology to medical imaging . It requires a complex set of spatial/visualization skills including mental rotation, spatial structure understanding, and viewpoint projection. Prior studies show that experts differ from novices in these skills. Method We have developed a novel training tool for inferring 2D cross-sections of 3D structures using a participatory design methodology. We used a between-subject study design, with 60 participants, to evaluate the training tool. Our primary effectiveness evaluation was based on pre- and postspatial tests that measured both cross-section abilities and specific spatial skills: viewpoint, mental rotation, and card rotation. Results Results showed significant performance gains on inferring 2D cross-sections for participants of the training group. Our tool improves two other spatial skills as well: mental rotation and viewpoint visualization. Conclusion Our training tool was effective not only in enhancing 2D cross-section understanding of complex 3D structures, but also in improving mental rotation and viewpoint visualization skills. Application Our tool can be beneficial in different fields such as medical imaging, biology, geology, and engineering. For example, an application of our tool is in medical/research labs to train novice segmenters in ongoing manual 3D segmentation tasks. It can also be adapted in other contexts, such as training children, older adults, and individuals with very low spatial skills.
Supine tubeless PCNL in horseshoe kidney (a series of cases)
Authors: Gupta Sandeep , Kasim Atar , Pal Dilip Kumar 
Published: May 2021

Objective: Objective of this case series is accurate access to the respective calyx with stone in horseshoe kidney while performing percutaneous nephrolithotmy in supine position. Reducing operative time and anaesthetic morbidity while performing percutaneous nephrolithotomy in horseshoe kidney with nephrolithiasis in supine position. Materials and Methods: Four patient with one having bilateral renal calculi with horshoe kidney were selected randomly. There were no preference for age, gender; size, location and laterality of stone or BMI. All the patients fit into the AUA guideline criteria for management by percutaneous nephrolithotomy. Preoperative, perioperative and follow up data were collected. Results: Four patients with one having bilateral renal calculi underwent supine tubeless PCNL in 1 year in GMSV position. There was no intraoperative, post operative or on follow up complications in any patient. In all the patients stones were cleared completely in single setting. Conclusion: Supine percutaneous nephrolithotomy in horseshoe kidney is an alternative to the standard prone percutaneous nephrolithotomy in the horseshoe kidney. It provides an additional benefit of performing the procedure in a single position, which is known to reduce total operating time, less anaesthesia related complications and less neuromusculoskeletal injury.
Emotional Disorders During the COVID-19 Outbreak in Spain: The Role of Sociodemographic Risk Factors and Cognitive Emotion Regulation Strategies
Authors: Muñoz-Navarro Roger , Cano Vindel Antonio , Schmitz Florian , Cabello Rosario , Fernández-Berrocal Pablo 
Published: May 2021

Background Cognitive emotion regulation strategies (CERS) play a transdiagnostic role in emotional disorders, but the role of these strategies in coping with emotions during the coronavirus disease 2019 (COVID-19) pandemic remains poorly understood. Aims To assess the presence of emotional disorders in Spain and the association to sociodemographic characteristics and CERS during the COVID-19 outbreak. Method Cross-sectional survey administered through an online platform. Sociodemographic variables and CERS (CERQ-Short) were collected and possible diagnoses of generalized anxiety disorder (GAD, GAD-7), major depression disorder (MDD; Patient Health Questionnaire–9 [PHQ-9]), panic attacks (PA; PHQ-PD), and panic disorders (PD; PHQ-PD) were assessed. Sociodemographic risk factors and CERS association to the possible diagnosis of emotional disorders were reported with hierarchical multivariate logistic regression analyses. Results A total of 1,753 respondents completed the questionnaire in Spain. Of these, most (76.8%) were female, with a mean ( SD) age of 40.4 years (12.9). A high proportion of participants met diagnostic criteria for emotional disorders: 15.3% for GAD, 12.2% for MDD, 17.2% for PD, and 25.7% had experienced a PA. The contribution of sociodemographic variables to diagnoses of emotional disorders was modest, explaining from 3.1% to 5.7% of the variance; however, when CERS were added, the combination of sociodemographic and CERS explained from 15% to 29% of the variance. Rumination and catastrophizing were the most transdiagnostic maladaptive strategies and positive refocusing was another adaptive strategy. Discussion Although results from convenience samples should be handled with caution, the high prevalence of emotional disorders in this study suggests that the demand of mental health interventions will probably increase in Spain. Also, CERS play a clear role in the presence of these disorders. Conclusion Intervention programs should focus on training CERS in populations at high risk, focusing on the reduction of maladaptive CERS and the reinforce of other more adaptive CERS.
Plasma Anthranilic Acid and Leptin Levels Predict HAM-D Scores in Depressed Women
Authors: Steiner Johann , Dobrowolny Henrik , Guest Paul C , Bernstein Hans-Gert , Fuchs Dietmar , Roeser Julien , Summergrad Paul , Oxenkrug Gregory F 
Published: May 2021

Objectives: Major depressive disorder (MDD) is associated with dysregulations of leptin and tryptophan–kynurenine (Trp–Kyn) (TKP) pathways. Leptin, a pro-inflammatory cytokine, activates Trp conversion into Kyn. However, leptin association with down-stream Kyn metabolites in MDD is unknown. Methods: Fasting plasma samples from 29 acutely ill drug-naïve (n = 16) or currently non-medicated (⩾6 weeks; n = 13) MDD patients were analyzed for leptin, Trp, Kyn, its down-stream metabolites (anthranilic [AA], kynurenic [KYNA], xanthurenic [XA] acids and 3-hydroxykynurenine [3HK]), C-reactive protein (CRP), neopterin, body mass index (BMI), and insulin resistance (HOMA-IR). Depression severity was assessed by HAM-D-21. Results: In female (n = 14) (but not in male) patients HAM-D-21 scores correlated with plasma levels of AA (but not other Kyn metabolites) (rho = −0.644, P = .009) and leptin (Spearman’s rho = −0.775, P = .001). Inclusion of AA into regression analysis improved leptin prediction of HAM-D from 48.5% to 65.9%. Actual HAM-D scores highly correlated with that calculated by formula: HAM-D = 34.8518−(0.5660 × leptin [ng/ml] + 0.4159 × AA [nmol/l]) (Rho = 0.84, P = .00015). In male (n = 15) (but not in female) patients leptin correlated with BMI, waist circumference/hip ratio, CRP, and HOMA-IR. Conclusions: Present findings of gender specific AA/Leptin correlations with HAM-D are important considering that AA and leptin are transported from plasma into brain, and that AA formation is catalyzed by kynureninase—the only TKP gene associated with depression according to genome-wide analysis. High correlation between predicted and actual HAM-D warrants further evaluation of plasma AA and leptin as an objective laboratory test for the assessment of depression severity in female MDD patients