bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is there a Meaningful General Factor of Personality?
Authors: Van der Linden Dimitri , Dunkel Curtis S. , Wu Peiqian 
Published: February 2021

Abstract
Numerous studies and meta-analyses have now confirmed that personality traits tend to correlate such that a general factor of personality (GFP) emerges. Nevertheless, there is an ongoing debate about what these correlations, and therefore the GFP, represents. One interpretation is that the GFP reflects a substantive factor that indicates general social effectiveness or emotional intelligence. Another interpretation is that the GFP merely is an artifact based on measurement or response bias. In the present paper, we elaborate on a selection of topics that are central to the debate about this construct. Specifically, we discuss (a) the GFP in relation to more specific personality dimensions (e.g., Big Five, facets), (b) the validity of the GFP and under what circumstances it seems to ‘disappear’, and (c) the theoretical and practical relevance of the general factor. Overall, the review should provide insight into the nature of the GFP and whether or not it represents a meaningful factor that can contribute to a better understanding of personality.
Blueberry and blackberry are tolerant to repeated indaziflam applications
Authors: Grey Timothy L. , Hurdle Nicholas L. , Rucker Keith , Basinger Nicholas T. 
Published: February 2021

AbstractNumerous perennial horticultural crops are grown across the southeastern United States. Blueberry and blackberry (also known as caneberry) are commonly found in roadside stands, promote agritourism via pick-your-own markets, are important for fresh market commercial production in the region, and when processed, provide desirable value added products. Season-long weed control using residual herbicides is crucial for these perennial fruit crops to maximize berry quality and yield. Studies performed from 2012 to 2014 in Lanier and Clinch counties in Georgia evaluated the effects of repeated applications of indaziflam at 35, 75, or 145 g ai ha−1 applied biannually in March and September (five total applications) on growth of ‘Alapaha’ rabbiteye and ‘Palmetto’ highbush blueberry, and ‘Apache’ thornless blackberry. All indaziflam treatments were mixed with glufosinate, and a glufosinate-only treatment was included as a check. Minor leaf chlorosis (<10%) was noted within 30 d after application for all blueberries for all treatments, but this was always transient. Blueberry stem diameter was not different for any treatment, even when indaziflam was applied up to 725 g ai ha−1 over 3 yr as compared to glufosinate alone. There was no chlorosis or stem diameter differences for blackberry noted for any treatment. Indaziflam applied in blueberry and blackberry production provides season-long control of numerous troublesome weed species, without causing injury or negatively impacting crop growth.
A Combined Neural Network‐ and Physics‐Based Approach for Modeling Plasmasphere Dynamics
Authors: Zhelavskaya I. S. , Aseev N. A. , Shprits Y. Y. 
Published: February 2021

AbstractIn recent years, feedforward neural networks (NNs) have been successfully applied to reconstruct global plasmasphere dynamics in the equatorial plane. These neural network‐based models capture the large‐scale dynamics of the plasmasphere, such as plume formation and erosion of the plasmasphere on the nightside. However, their performance depends strongly on the availability of training data. When the data coverage is limited or non‐existent, as occurs during geomagnetic storms, the performance of NNs significantly decreases, as networks inherently cannot learn from the limited number of examples. This limitation can be overcome by employing physics‐based modeling during strong geomagnetic storms. Physics‐based models show a stable performance during periods of disturbed geomagnetic activity if they are correctly initialized and configured. In this study, we illustrate how to combine the neural network‐ and physics‐based models of the plasmasphere in an optimal way by using data assimilation. The proposed approach utilizes advantages of both neural network‐ and physics‐based modeling and produces global plasma density reconstructions for both quiet and disturbed geomagnetic activity, including extreme geomagnetic storms. We validate the models quantitatively by comparing their output to the in‐situ density measurements from RBSP‐A for an 18‐month out‐of‐sample period from June 30, 2016 to January 01, 2018 and computing performance metrics. To validate the global density reconstructions qualitatively, we compare them to the IMAGE EUV images of the He+ particle distribution in the Earth's plasmasphere for a number of events in the past, including the Halloween storm in 2003.
Impact of EMIC‐Wave Driven Electron Precipitation on the Radiation Belts and the Atmosphere
Authors: Hendry A. T. , Seppälä A. , Rodger C. J. , Clilverd M. A. 
Published: February 2021

AbstractIn recent years, there has been a growing body of direct experimental evidence demonstrating electromagnetic ion cyclotron (EMIC) waves driving energetic electron precipitation (EEP) at unexpectedly low, sub‐MeV energies—as low as only a few hundred keV. EMIC‐wave driven scattering at these energies has important ramifications for our understanding of not only radiation belt electron dynamics, but also the importance of EMIC‐driven EEP to the chemical balance of the Earth's atmosphere. In this study, we use three experimentally derived EMIC‐driven EEP flux spectra to investigate the impact of this precipitation on trapped radiation belt fluxes. In doing so, we resolve an apparent contradiction with earlier results derived from trapped electron flux populations that suggested EMIC waves only caused significant scattering at ultrarelativistic energies. We show that strong sub‐MeV EEP measurements are not necessarily mutually exclusive with a strongly relativistic‐only trapped flux response, as the sub‐MEV peak precipitation is comparatively much smaller than the trapped population at those energies. Using a further six EEP spectra, we also demonstrate that EMIC‐driven EEP can generate significant ionization of the Earth's atmosphere above 40 km, leading to the loss of mesospheric ozone. We find poor correlation between EMIC‐driven EEP fluxes and geomagnetic activity proxies, such that EMIC‐driven EEP is likely to be poorly specified in the forcing factors of modern coupled‐climate models.
Wave Steepening in Ionospheric Total Electron Density due to the 21 August 2017 Total Solar Eclipse
Authors: Sun Yang‐Yi , Shen Mitchell M. , Tsai Yu‐Lin , Lin Chi‐Yen , Chou Min‐Yang , Yu Tao , Lin Kai , Huang Qian , Wang Jin , Qiu Lihui , Chen Chieh‐Hung , Liu Jann‐Yenq 
Published: February 2021

AbstractThis study shows that a supersonic moon shadow of a total solar eclipse can steepen the ionospheric total electron content (TEC) wave on August 21, 2017. A data‐adaptive method named Hilbert‐Huang transform is employed to examine the nonlinear and non‐stationary evolution of the waves. The results show that the TEC wave behaves as a traveling ionospheric disturbance before the totality appearance, turns later into steepening, and breaks eventually. A TEC wave with a period of ∼40 min and wavelength of ∼1,000 km propagates mainly in an east‐southward direction before the totality appearance. The wave amplitude and scales, respectively, increases and reduce by near ∼50% as the moon shadow approaches the western coast of the continental United States. The short‐period TEC waves (period ∼2 min) reveal that the wave may break eventually when the wave gets steeper. The steepness of the TEC wave is reconstructed according to the constructive interference.
Study of Sediment Transport in a Tidal Channel‐Shoal System: Lateral Effects and Slack‐Water Dynamics
Authors: Zhou Zaiyang , Ge Jianzhong , van Maren D. S. , Wang Zheng Bing , Kuai Yu , Ding Pingxing 
Published: February 2021

AbstractLateral flows redistribute sediment and influence the morphodynamics of channel‐shoal systems. However, our understanding of lateral transport of suspended sediment during high and low water slack is still fairly limited, especially in engineered estuaries. Human interventions such as dike‐groyne structures influence lateral exchange mechanisms. The present study aims to unravel these mechanisms in a heavily engineered, turbid channel‐shoal system in the Changjiang Estuary, using a high‐resolution unstructured‐grid three‐dimensional model and in situ observations. Analysis of model results reveals two typical transport patterns during slack‐water conditions, that is, shoal‐to‐channel transport during low water slack and channel‐to‐shoal transport during high water slack. A momentum balance analysis is carried out to explain mechanisms driving the lateral transport of suspended sediment during high water slack, revealing the importance of lateral pressure gradients, Coriolis force, and the curvature‐induced term. Groyne fields play a crucial role in sediment transport, especially during low water slack. A model scenario in which one groyne is removed reveals that groyne fields strongly influence lateral sediment transport. The decomposition of the sediment transport flux reveals that the turbidity maximum is shaped by a balance between seaward advection by residual flows, and landward transport by tidal pumping and gravitational circulation. Within the turbidity maximum, sediment is laterally redistributed by lateral flows during slack‐water conditions, greatly influencing estuarine channel morphology.
Rain Evaporation, Snow Melt, and Entrainment at the Heart of Water Vapor Isotopic Variations in the Tropical Troposphere, According to Large‐Eddy Simulations and a Two‐Column Model
Authors: Risi Camille , Muller Caroline , Blossey Peter 
Published: February 2021

AbstractWe aim at developing a simple model as an interpretative framework for the water vapor isotopic variations in the tropical troposphere over the ocean. We use large‐eddy simulations of disorganized convection in radiative‐convective equilibrium to justify the underlying assumptions of this simple model, to constrain its input parameters and to evaluate its results. We also aim at interpreting the depletion of the water vapor isotopic composition in the lower and midtroposphere as precipitation increases, which is a salient feature in tropical oceanic observations. This feature constitutes a stringent test on the relevance of our interpretative framework. Previous studies, based on observations or on models with parameterized convection, have highlighted the roles of deep convective and mesoscale downdrafts, rain evaporation, rain‐vapor diffusive exchanges, and mixing processes. The interpretative framework that we develop, valid in case of disorganized convection, is a two‐column model representing the net ascent in clouds and the net descent in the environment. We show that the mechanisms for depleting the troposphere as the precipitation rate increases all stem from the higher tropospheric relative humidity. First, when the relative humidity is larger, less snow sublimates before melting and a smaller fraction of rain evaporates. Both effects lead to more depleted rain evaporation and eventually more depleted water vapor. This mechanism dominates in regimes of large‐scale ascent. Second, the entrainment of dry air into clouds reduces the vertical isotopic gradient and limits the depletion of tropospheric water vapor. This mechanism dominates in regimes of large‐scale descent.
The Novel Hydroxylated Tetraether Index RI‐OH′ as a Sea Surface Temperature Proxy for the 160‐45 ka BP Period Off the Iberian Margin
Authors: Davtian Nina , Bard Edouard , Darfeuil Sophie , Ménot Guillemette , Rostek Frauke 
Published: February 2021

AbstractRI‐OH′ and RI‐OH (ring index of hydroxylated tetraethers) are two novel organic paleothermometers which could either complement or replace more established paleothermometric proxies, such as UK′37 (C37 ketone unsaturation ratio) and TEX86 (TetraEther indeX of tetraethers consisting of 86 carbon atoms). Despite a few promising attempts, the paleothermometric potential of RI‐OH′ and RI‐OH is not fully constrained. Here we present new high‐resolution temperature records over the 160‐45 ka BP (before present = year 1950 CE) period using four organic proxies (RI‐OH′, RI‐OH, TEX86, and UK′37) from three deep sea sediment cores located in a north‐south transect along the Iberian Margin. We analyzed all organic proxies from a single set of lipid extracts to optimize proxy‐proxy comparisons and phase relationship studies. RI‐OH′ responds to Dansgaard‐Oeschger and Heinrich events, better resembles UK′37 than TEX86, and better records the influence of (sub)polar waters during Heinrich events than does RI‐OH. While RI‐OH′ gives realistic sea surface temperatures and latitudinal gradients coherent with those from independent paleothermometers, a more extensive RI‐OH′‐temperature calibration for the North Atlantic is clearly needed. However, the absence of a significant warm bias in RI‐OH′‐based temperatures compared to a shallow sea site suggests that endemic, deep‐dwelling archeal communities affect TEX86 but not RI‐OH′ in the Iberian Margin. TEX86 leads RI‐OH′ and UK′37 during four Heinrich‐like events, potentially due to background fluxes from deep waters for nonhydroxylated tetraethers summed with primary productivity dependent fluxes from surface waters for all investigated lipid classes. Relationships with Greenland temperatures further support RI‐OH′‐based paleothermometry.
Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study
Authors: Michikawa Takehiro , Morokuma Seiichi , Yamazaki Shin , Takami Akinori , Sugata Seiji , Yoshino Ayako , Takeda Yuki , Nakahara Kazushige , Saito Shinji , Hoshi Junya , Kato Kiyoko , Nitta Hiroshi , Nishiwaki Yuji 
Published: February 2021

Abstract
Background
Maternal exposure to fine particulate matter (PM2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM2.5 are more harmful for maternal and foetal health.

Objective
We focused on exposure over the first trimester (0–13 weeks of gestation), which includes the early placentation period, and investigated whether PM2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth).

Methods
From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton infants within 23 Tokyo wards (≈627 km2). Using daily filter sampling of PM2.5 at one monitoring location, we analysed carbon and ion components, and assigned the first trimester average of the respective pollutant concentrations to each woman.

Results
The ORs of placenta-mediated pregnancy complications were 1.14 (95% CI = 1.08–1.22) per 0.51 μg/m3 (interquartile range) increase of organic carbon and 1.11 (1.03–1.18) per 0.06 μg/m3 increase of sodium. Organic carbon was also associated with four individual complications. There was no association between ozone and outcome.

Significance
There were specific components of PM2.5 that have adverse effects on maternal and foetal health.
Longitudinal evaluation of whole blood miRNA expression in firefighters
Authors: Jung Alesia M. , Zhou Jin , Beitel Shawn C. , Littau Sally R. , Gulotta John J. , Wallentine Darin D. , Moore Paul K. , Burgess Jefferey L. 
Published: February 2021

Abstract
Background
Dysregulated microRNA (miRNA) expression could provide a mechanism linking firefighter exposure to increased cancer risk.

Objective
To determine if changes in longitudinal miRNA expression in firefighters are associated with occupational exposures.

Methods
Whole blood MiRNA was evaluated in 52 new recruits prior to live-fire training and 20–37 months later. Linear mixed effects models adjusted for age, ethnicity, BMI, and batch effects were used to determine associations separately for all fires and structure fires only between employment duration, cumulative fire-hours and fire-runs, and time since most recent fire with (1) nine a priori and (2) the full array of 799 miRNAs.

Results
For multivariable models including all fires, two a priori miRNAs were associated with employment duration and four with time since most recent fire. For multivariable models restricted to structure fires, three a priori miRNAs were associated with employment duration and one with fire-runs. Additional miRNAs from the full array were associated with employment duration for all fires and/or structure fires. In general, tumor suppressive miRNAs decreased and oncogenic miRNAs increased with exposure.

Significance
Changes in miRNAs may serve as biomarkers of exposure effects and a mechanism for increased cancer risk in firefighters.
Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
Authors: Osemlak Paweł , Miszczuk Konrad , Jędrzejewski Grzegorz , Nachulewicz Paweł , Beń-Skowronek Iwona , Brzozowska Agnieszka 
Published: February 2021

Abstract
Background
Torsion of the testis is an urgent surgical condition that endangers the viability of the gonad and the fertility of the patient. Our aim was to assess potential autoimmune processes and hormonal abnormalities in boys operated on due to that illness.

Methods
The authors evaluated the levels of antibodies against sperm and Leydig cells, concentrations of follicle-stimulating, luteinizing and anti-Müllerian hormone, testosterone, oestradiol and vascular endothelial growth factor in the serum in 28 boys operated on due to torsion of the testis. Patients’ sexual maturity was assessed according the Tanner scale (group G1, G4 and G5).

Results
No antibodies against sperm or Leydig cells were found in the serum. Statistically significant differences in follicle-stimulating and anti-Müllerian hormone concentrations were observed in the G1, and they were higher in the study than in the control group. There were no statistically significant differences in luteinizing hormone, testosterone, oestradiol and vascular endothelial growth factor concentrations in the study group or control group. Testosterone concentration was unrelated to total testicular volume.

Conclusions
Results did not confirm the autoimmune process in boys with torsion of the testis. The pituitary–testis axis seems to have sufficient compensation capabilities. However, study results suggest that primary gonadal dysfunction may predispose to torsion.

Impact

Significant differences exist between the literature data and own results on the formation of antibodies and hormonal changes due to testicular torsion in boys.

It is a novel, prospective study on antibodies against sperms and Leydig cells in the serum and on hormonal processes occurring as a result of the testicular torsion from the prenatal period to the adolescence with division into pubertal groups.

The study has revealed sufficient compensation capabilities of the pituitary–testis axis and no autoimmune process in boys with torsion of the testis.
Cell death in head and neck cancer pathogenesis and treatment
Authors: Raudenská Martina , Balvan Jan , Masařík Michal 
Published: February 2021

AbstractMany cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence of oncogenic alterations in these cells and distorted composition of tumour microenvironment largely limit the clinical efficacy of this type of therapy. Luckily, scientific consensus describes about 10 different cell death subroutines with different regulatory pathways and cancer cells are probably not able to avoid all of cell death types at once. Therefore, a focused and individualised therapy is needed to address the specific advantages and disadvantages of individual tumours. Although much is known about apoptosis, therapeutic opportunities of other cell death pathways are often neglected. Molecular heterogeneity of head and neck squamous cell carcinomas (HNSCC) causing unpredictability of the clinical response represents a grave challenge for oncologists and seems to be a critical component of treatment response. The large proportion of this clinical heterogeneity probably lies in alterations of cell death pathways. How exactly cells die is very important because the predominant type of cell death can have multiple impacts on the therapeutic response as cell death itself acts as a second messenger. In this review, we discuss the different types of programmed cell death (PCD), their connection with HNSCC pathogenesis and possible therapeutic windows that result from specific sensitivity to some form of PCD in some clinically relevant subgroups of HNSCC.
Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus
Authors: Cararo-Lopes Eduardo , Dias Matheus H. , da Silva Marcelo S. , Zeidler Julianna D. , Vessoni Alexandre T. , Reis Marcelo S. , Boccardo Enrique , Armelin Hugo A. 
Published: February 2021

AbstractMalignant transformation involves an orchestrated rearrangement of cell cycle regulation mechanisms that must balance autonomic mitogenic impulses and deleterious oncogenic stress. Human papillomavirus (HPV) infection is highly prevalent in populations around the globe, whereas the incidence of cervical cancer is 0.15%. Since HPV infection primes cervical keratinocytes to undergo malignant transformation, we can assume that the balance between transforming mitogenic signals and oncogenic stress is rarely attained. We showed that highly transforming mitogenic signals triggered by HRasG12V activity in E6E7–HPV–keratinocytes generate strong replication and oxidative stresses. These stresses are counteracted by autophagy induction that buffers the rapid increase of ROS that is the main cause of genotoxic stress promoted by the oncoprotein. As a result, autophagy creates a narrow window of opportunity for malignant keratinocytes to emerge. This work shows that autophagy is crucial to allow the transition of E6E7 keratinocytes from an immortalized to a malignant state caused by HRasG12V.
Polycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice
Authors: Zhang Junling , Li Kui , Zhang Qianru , Zhu Zhimei , Huang Gongchao , Tian Hongqi 
Published: February 2021

AbstractAmifostine has been the only small molecule radio-protector approved by FDA for decades; however, the serious adverse effects limit its clinical use. To address the toxicity issues and maintain the good potency, a series of modified small polycysteine peptides had been prepared. Among them, compound 5 exhibited the highest radio-protective efficacy, the same as amifostine, but much better safety profile. To confirm the correlation between the radiation-protective efficacy and the DNA binding capability, each of the enantiomers of the polycysteine peptides had been prepared. As a result, the l-configuration compounds had obviously higher efficacy than the corresponding d-configuration enantiomers; among them, compound 5 showed the highest DNA binding capability and radiation-protective efficacy. To our knowledge, this is the first study that has proved their correlations using direct comparison. Further exploration of the mechanism revealed that the ionizing radiation (IR) triggered ferroptosis inhibition by compound 5 could be one of the pathways for the protection effect, which was different from amifostine. In summary, the preliminary result showed that compound 5, a polycysteine as a new type of radio-protector, had been developed with good efficacy and safety profile. Further study of the compound for potential use is ongoing.