bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI KESEHATAN PENCEGAHAN COVID 19 DI KELURAHAN MARGASARI KOTA BALIKPAPAN
Authors: Anam Hairul 
Published: September 2021

Kegiatan sosialisasi kesehatan pencegahan covid 19 merupakan kegiatan pengabdian kepada masyarakat dalam upaya kontribusi kepada masyarakat untuk pemenuhan kebutuhan hidup dan menyelesaikan permasalahan yang dialami masyarakat khususnya dalam pencegahan penularan Covid-19. Kegiatan ini dilaksanakan melalui program Sosialisasi kesehatan pencegahan Covid-19 yang merupakan kegiatan berbasis pengabdian kepada masyarakat untuk meningkatkan pengetahuan tentang upaya memutus mata rantai penularan Covid-19 dilaksanakan di Kelurahan Margasari, Kecamatan Balikpapan Barat Kota Balikpapan dengan metode pengabdian berupa kegiatan sosialisasi dan kegiatan lapangan dilingkungan perumahan dan pedagang usaha mikro kecil dan menengah. Pengabdian kepada masyarakat ini mendapat respon positif pemerintah serta partisipasi aktif masyarakat yang tinggi, dan diharakpan selalu mematuhi protokol kesehatan 5M.
PENGARUH PEMBERIAN TERAPI ANTIPSIKOTIK KOMBINASI TERHADAP TINGKAT DEPRESI PASIEN SKIZOFRENIA DI UPT PUSKESMAS TALUN KABUPATEN BLITAR
Authors: Susilowati Sri , Aditya Martanty , Yoedistira Chresiani Destianita 
Published: September 2021

Skizofrenia merupakan penyakit psikiatrik kronis yang banyak menimbulkan masalah psikologis. Penatalaksanaannya dengan memberikan obat antipsikotik, diberikan dalam bentuk kombinasi. Penggunaan yang tidak tepat dapat menyebabkan terjadinya depresi dan kemungkinan mengalami efek samping terapi. Oleh karena itu perlu diukur efektifitas terapi yang diukur melalui tingkat depresi meliputi depresi ringan, sedang, berat, sangat berat.Penelitian ini merupakan penelitian observasional dengan pendekatan cross sectional. Penelitian ini melibatkan 58 responden. Pengambilan data dilakukan dengan cara retrospektif, kemudian dilanjutkan dengan wawancara terstruktur oleh peneliti dibantu oleh asisten peneliti dengan instrument kuesioner Hamilton Depression Rating Scale (HDRS). Penelitian ini dilakukan pada penderita skizofrenia di UPT Puskesmas Talun Kabupaten Blitar pada bulan April-Juli 2020. Dilakukan uji validitas dan reliabilitas pada kuesioner Hamilton Depression Rating Scale (HDRS). Pengaruh pemberian terapi antipsikotik kombinasi terhadap tingkat depresi dilakukan menggunakan uji Kruskal Wallis, dan didapatkan bahwa probabilitas > alpha (5%), tidak terdapat perbedaan yang signifikan pada pemberian antipsikotik kombinasi, dan dilaporkan pula efek samping berupa ekstrapiramidal ringan, ekstrapiramidal berat dan tremor. Pada kombinasi I dilaporkan terjadi efek samping ektrapiramidal ringan 1 pasien, berat 1 pasien, tremor 1 pasien. Pada kombinasi II dilaporkan terjadi efek samping ekstrapiramidal ringan 2 pasien dan pada kombinasi III dilaporkan tidak ada kejadian efek samping.
PERANCANGAN BUKU CERITA DIGITAL LEGENDA BATU MENANGIS DAN GAME INTERAKTIF BERBASIS ANDROID UNTUK PENANAMAN NILAI MORAL USIA 4-6 TAHUN
Authors: Handoko Nathania Maharani Lynn , Rahmadianto Sultan Arif , Sukmaraga Ayyub Anshari 
Published: September 2021

Indonesia saat ini dihadapkan dengan penurunan moral budaya yang terjadi pada generasi muda khususnya tentang nilai moral menghormati dan berbakti kepada orang tua. Di masa lalu masyarakat Indonesia menggunakan sastra cerita rakyat dalam menanamkan nilai moral secara turun-temurun, tetapi dampak dari era globalisasi secara perlahan telah menggeser budaya yang sudah ada sebelumnya. Maka dari itu diperlukan sebuah media baru agar dapat kembali menanamkan nilai-nilai moral yang terkandung dalam cerita rakyat kepada generasi-generasi penerus bangsa. Cerita yang diangkat yaitu Legenda Batu Menangis yang berasal dari Kalimantan Barat. Dalam perancangan buku cerita digunakan media berupa aplikasi sebagai bentuk output perancangan. Metode perancangan yang digunakan yaitu metode Research & Development (R&D) yang dalam pengumpulan datanya mengunakan metode kualitatif. Perancangan aplikasi buku cerita digital menggunakan audio dalam pembacaan narasi dan dialog. Selain itu terdapat juga 3 jenis game interaktif pada aplikasi. Kesimpulan dari perancangan yaitu mendapatkan hasil visual aplikasi pada buku cerita dan juga game yang menarik dan menyenangkan bagi anak-anak. Perancangan aplikasi juga didukung oleh beberapa media pendukung seperti sticker, coloring book, tumbler, dan filter Instagram.
Solution of one hypersingular integro-differential equation defined by determinants
Authors: Shilin Andrei P. 
Published: September 2021

The paper provides an exact analytical solution to a hypersingular inregro-differential equation of arbitrary order. The equation is defined on a closed curve in the complex plane. A characteristic feature of the equation is that if is written using determinants. From the view of the traditional classification of the equations, it should be classified as linear equations with vatiable coefficients of a special form. The method of analytical continuation id applied. The equation is reduced to a boundary value problem of linear conjugation for analytic functions with some additional conditions. If this problem is solvable, if is required to solve two more linear differential equations in the class of analytic functions. The conditions of solvability are indicated explicitly. When these conditions are met, the solution can also be written explicitly. An example is given.
Effect of Oxygen Contamination on Propionate and Caproate Formation in Anaerobic Fermentation
Authors: Baleeiro Flávio C. F. , Ardila Magda S. , Kleinsteuber Sabine , Sträuber Heike 
Published: September 2021

Mixed microbial cultures have become a preferred choice of biocatalyst for chain elongation systems due to their ability to convert complex substrates into medium-chain carboxylates. However, the complexity of the effects of process parameters on the microbial metabolic networks is a drawback that makes the task of optimizing product selectivity challenging. Here, we studied the effects of small air contaminations on the microbial community dynamics and the product formation in anaerobic bioreactors fed with lactate, acetate and H2/CO2. Two stirred tank reactors and two bubble column reactors were operated with H2/CO2 gas recirculation for 139 and 116 days, respectively, at pH 6.0 and 32°C with a hydraulic retention time of 14 days. One reactor of each type had periods with air contamination (between 97 ± 28 and 474 ± 33 mL O2 L−1 d−1, lasting from 4 to 32 days), while the control reactors were kept anoxic. During air contamination, production of n-caproate and CH4 was strongly inhibited, whereas no clear effect on n-butyrate production was observed. In a period with detectable O2 concentrations that went up to 18%, facultative anaerobes of the genus Rummeliibacillus became predominant and only n-butyrate was produced. However, at low air contamination rates and with O2 below the detection level, Coriobacteriia and Actinobacteria gained a competitive advantage over Clostridia and Methanobacteria, and propionate production rates increased to 0.8–1.8 mmol L−1 d−1 depending on the reactor (control reactors 0.1–0.8 mmol L−1 d−1). Moreover, i-butyrate production was observed, but only when Methanobacteria abundances were low and, consequently, H2 availability was high. After air contamination stopped completely, production of n-caproate and CH4 recovered, with n-caproate production rates of 1.4–1.8 mmol L−1 d−1 (control 0.7–2.1 mmol L−1 d−1). The results underline the importance of keeping strictly anaerobic conditions in fermenters when consistent n-caproate production is the goal. Beyond that, micro-aeration should be further tested as a controllable process parameter to shape the reactor microbiome. When odd-chain carboxylates are desired, further studies can develop strategies for their targeted production by applying micro-aerobic conditions.
Ultrasound-Assisted Production of Xylo-Oligosaccharides From Alkali-Solubilized Corncob Bran Using Penicillium janthinellum XAF01 Acidic Xylanase
Authors: Zhou Mingchun , Fan Guangsen , Xia Hanshuo , Zhang Xiaohan , Teng Chao , Li Xiuting 
Published: September 2021

A novel treatment involving enzymatic hydrolysis using an acidic xylanase coupled with ultrasound was performed to improve the xylo-oligosaccharides (XOS) yield from corncob bran. The acidic xylanase (XynB) was purified to a most suitable pH, temperature, and operational parameters for ultrasound-assisted hydrolysis were determined. A preliminary mechanistic investigation was performed through circular dichroism (CD) spectroscopy, scanning electron microscope (SEM) and a laser particle size analyzer, and the effects of ultrasound on enzyme (XynB) and substrate (corncob bran) were assessed. The results show that the maximum XOS yield was 20.71% when the reaction pH and temperature were 4.3 and 50°C, the ultrasonic parameters were 50 kHz and 0.40 W/cm2, which was 2.55 fold higher than that obtained using a non-ultrasound-assisted enzymatic preparation. Mechanism studies indicated that ultrasonic pretreatment could reduce the β-fold content and increase the random coil content. Changes in structure and size of substrate were observed. The specific surface area of the XAC molecules is easy to carry out enzymatic reaction, which is beneficial to the production of XOS.
Sedimentary Provenance Changes Constrain the Eocene Initial Uplift of the Central Pamir, NW Tibetan Plateau
Authors: Wang Ping , Liu Dongliang , Li Haibing , Chevalier Marie-Luce , Wang Yadong , Pan Jiawei , Zheng Yong , Ge Chenglong , Bai Mingkun , Wang Shiguang 
Published: September 2021

The Pamir Plateau region of the Northwestern Tibetan Plateau forms a prominent tectonic salient, separating the Tajik and Tarim basins. However, the topographic evolution of the Pamir Plateau remains elusive, despite the key role of this region played in the retreat of the Paratethys Ocean and in aridification across Central Asia. Therefore, the SW Tarim and Tajik basins are prime locations to decipher the geological history of the Pamir Plateau. Here, we present detrital zircon U/Pb and apatite fission-track (DAFT) ages from the Keliyang section of the SW Tarim Basin. DAFT ages show that sediments had three components during the Late Cretaceous and two components since the Oligocene. Detrital zircon U/Pb ages mainly cluster between 400 and 500 Ma during the Late Cretaceous, and coincide with ages of the Songpan-Ganzi and the West Kunlun Mountains. In contrast, detrital zircon U/Pb ages in the Eocene sediments are centered at around 200–300 Ma and 40–70 Ma, with a peak at ∼45 Ma, consistent with data from the Central Pamir and the West Kunlun Mountains. The ∼45 Ma peak in detrital zircon U/Pb ages since the Eocene indicates a new sedimentary source from the Central Pamir. Non-metric multi-dimensional scaling (MDS) analyses also show that the sedimentary source was closer to the Central Pamir after the Eocene, when compared to the Late Cretaceous. The result shows a clear Eocene provenance change in the Keliyang area. Moreover, this Eocene provenance shift has been detected in previous studies, in both the Tajik and Tarim basins, suggesting that the entire Central Pamir region likely experienced quasi-simultaneous abrupt uplift and paleo-geomorphological changes during the Eocene.
Biohydrogen Production From Biomass Sources: Metabolic Pathways and Economic Analysis
Authors: Ahmed Shams Forruque , Rafa Nazifa , Mofijur M. , Badruddin Irfan Anjum , Inayat Abrar , Ali Md Sawkat , Farrok Omar , Yunus Khan T. M. 
Published: September 2021

The commercialization of hydrogen as a fuel faces severe technological, economic, and environmental challenges. As a method to overcome these challenges, microalgal biohydrogen production has become the subject of growing research interest. Microalgal biohydrogen can be produced through different metabolic routes, the economic considerations of which are largely missing from recent reviews. Thus, this review briefly explains the techniques and economics associated with enhancing microalgae-based biohydrogen production. The cost of producing biohydrogen has been estimated to be between $10 GJ-1 and $20 GJ−1, which is not competitive with gasoline ($0.33 GJ−1). Even though direct biophotolysis has a sunlight conversion efficiency of over 80%, its productivity is sensitive to oxygen and sunlight availability. While the electrochemical processes produce the highest biohydrogen (&gt;90%), fermentation and photobiological processes are more environmentally sustainable. Studies have revealed that the cost of producing biohydrogen is quite high, ranging between $2.13 kg−1 and 7.24 kg−1via direct biophotolysis, $1.42kg−1 through indirect biophotolysis, and between $7.54 kg−1 and 7.61 kg−1via fermentation. Therefore, low-cost hydrogen production technologies need to be developed to ensure long-term sustainability which requires the optimization of critical experimental parameters, microalgal metabolic engineering, and genetic modification.
Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China
Authors: Zhang Fei , Liang Bingyu , Liang Xu , Lin Zhaosen , Yang Yuan , Liang Na , Yang Yao , Liang Huayue , Jiang Jiaxiao , Huang Jiegang , Huang Rongye , Zhong Shanmei , Qin Cai , Jiang Junjun , Ye Li , Liang Hao 
Published: September 2021

IntroductionPretreatment drug resistance (PDR) is becoming an obstacle to the success of ART. This study investigated the prevalence of PDR and the transmission clusters (TCs) of drug resistance mutations (DRMs) in two cities where drug abuse used to be high to describe the local HIV-1 transmission dynamics.MethodsPlasma samples were obtained from 1,027 ART-naïve patients in Guangxi. Viral subtypes and DRMs were identified. Transmission network and related factors were also determined.ResultsA total of 1,025 eligible sequences were obtained from Qinzhou (65.8%) and Baise (34.2%) cities. The predominant HIV-1 genotype was CRF08_BC (45.0%), followed by CRF01_AE (40.9%). The overall prevalence of PDR was 8.3%, and resistance to NNRTI was the most common. Putative links with at least one other sequence were found in 543/1,025 (53.0%) sequences, forming 111 clusters (2–143 individuals). The most prevalent shared DRMs included V106I (45.35%), V179D (15.1%), and V179E (15.1%). Clusters related to shared DRMs were more frequent and larger in CRF08_BC. The prevalence of shared DRMs increased with time, while the proportion of PDR gradually decreased. Age &gt; 50 years was associated with clustering. Subtype CRF08_BC was more likely to have DRMs, PDR propagation, and DRM sharing.ConclusionPDR prevalence is moderate in this region. The association between PDR and subtype CRF08_BC suggested that DRMs spreading from injection drug users (IDUs) to heterosexuals (HETs) might be the major source of PDR in this region. Our findings highlight the significance of continuous surveillance of PDR.
Global Pattern of CD8+ T-Cell Infiltration and Exhaustion in Colorectal Cancer Predicts Cancer Immunotherapy Response
Authors: Tian Sun , Wang Fulong , Zhang Rongxin , Chen Gong 
Published: September 2021

Background: The MSI/MSS status does not fully explain cancer immunotherapy response in colorectal cancer. Thus, we developed a colorectal cancer-specific method that predicts cancer immunotherapy response.Methods: We used gene expression data of 454 samples (MSI = 131, MSI-L = 23, MSS = 284, and Unknown = 16) and developed a TMEPRE method that models signatures of CD8+ T-cell infiltration and CD8+ T-cell exhaustion states in the tumor microenvironment of colorectal cancer. TMEPRE model was validated on three RNAseq datasets of melanoma patients who received pembrolizumab or nivolumab and one RNAseq dataset of purified CD8+ T cells in different exhaustion states.Results: TMEPRE showed predictive power in three datasets of anti-PD1-treated patients (p = 0.056, 0.115, 0.003). CD8+ T-cell exhaustion component of TMEPRE model correlates with anti-PD1 responding progenitor exhausted CD8+ T cells in both tumor and viral infection (p = 0.048, 0.001). The global pattern of TMEPRE on 454 colorectal cancer samples indicated that 10.6% of MSS patients and 67.2% of MSI patients show biological characteristics that can potentially benefit from anti-PD1 treatment. Within MSI nonresponders, approximately 50% showed insufficient tumor-infiltrating CD8+ T cells and 50% showed terminal exhaustion of CD8+ T cells. These terminally exhausted CD8+ T cells coexisted with signatures of myeloid-derived suppressor cells in colorectal cancer.Conclusion: TMEPRE is a colorectal cancer-specific method. It captures characteristics of CD8+ T-cell infiltration and CD8+ T-cell exhaustion state and predicts cancer immunotherapy response. A subset of MSS patients could potentially benefit from anti-PD1 treatment. Anti-PD1 resistance MSI patients with insufficient infiltration of CD8+ T cells or terminal exhaustion of CD8+ T cells need different treatment strategies.
Comparison of Methods for the Estimation of the Maximum Oxygen Uptake of Men Drug Addicts
Authors: Wang Kun , Jiang Haonan , Zhang Tingran , Yin Lian , Chen Xi , Luo Jiong 
Published: September 2021

Background: Maximum oxygen uptake (VO2max) is an important respiratory physiological index of the aerobic endurance of the body, especially for special groups such as drug addicts, and it is an important indicator for assessing the cardiopulmonary function and formulating exercise prescriptions. Although the cardiopulmonary exercise test (CPX) is a classic method to directly measure VO2max, this method is limited by factors such as cumbersome operating procedures and expensive equipment, resulting in its relatively low applicability. Recently, many studies have begun to focus on the estimation of VO2max in different groups of people, but few studies have focused on drug addicts.Methods: Fifteen chemically synthesized drug addicts (such as amphetamines) and Fifteen plant-derived drug addicts (such as heroin) were recruited at the Chongqing Compulsory Isolation and Drug Rehabilitation Center in China. First, the VO2max of subjects was directly measured through the CPX. Second, after subjects were fully rested, they were required to complete the 30-s high-leg raise, 1,000-m walk, and 3-min step experiment. Finally, SPSS 21.0 software was used to perform the correlation and linear regression analysis to verify the estimated effectiveness.Results: (1) Regardless of chemically synthesized or natural plant-derived drug addicts, the years of drug use and walking time of 1,000 m were significantly negatively correlated with VO2max (chemically synthesized: P &lt; 0.01 and natural plant-derived: P &lt; 0.05), the number of 30-s high-leg raises was a significantly positive correlation with VO2max (P &lt; 0.05 and P &lt; 0.01), and the 3-min step index was significantly positively correlated with VO2max (P &lt; 0.01 and P &lt; 0.01). (2) Regression analysis shows that the 30-s high-leg lift, 1,000-m walking, and 3-min step experiment could effectively estimate the VO2max of chemically synthesized and natural plant-derived drug addicts. (3) Multiple linear regression constructed by the years of drug use combined with the step index has the highest estimated accuracy for the VO2max of chemically synthesized drug addicts (96.48%), while the unary regression equation established by a single step index has the highest prediction accuracy for the VO2max of natural plant-derived addicts (94.30%).Conclusion: The indirect measurement method could effectively estimate the VO2max of drug addicts, but different measurement methods have certain differences in the estimation accuracy of VO2max of different drug addicts. In the future, the physical characteristics of drug users can be fully considered, combined with more cutting-edge science and technology, to make the estimation accuracy of VO2max closer to the real level.
Electrodermal Response to Mirror Exposure in Relation to Subjective Emotional Responses, Emotional Competences and Affectivity in Adolescent Girls With Restrictive Anorexia and Healthy Controls
Authors: Knejzlíková Terézia , Světlák Miroslav , Malatincová Tatiana , Roman Robert , Chládek Jan , Najmanová Jana , Theiner Pavel , Linhartová Pavla , Kašpárek Tomáš 
Published: September 2021

Objective:Body image disturbances and the attendant negative emotions are two of the major clinical symptoms of eating disorders. The objective of the present experimental study was to shed more light on the degree of association or dissociation between the physiological and emotional response to mirror exposure in patients with restrictive mental anorexia, and on the relationships between the physiological response and characteristics connected with emotional processing.Materials and Methods:Thirty adolescent girls with the restrictive type of anorexia and thirty matched healthy controls underwent bilateral measurement of skin conductance (SC) during rest, neutral stimulus exposure, and mirror exposure, and completed a set of measures focused on emotion regulation competencies, affectivity, and eating disorder pathology.Results:Compared to healthy controls, girls with restrictive anorexia rated mirror exposure as a subjectively more distressful experience. Differences in skin conductance response (SCR) were not significant; however, variance in SCR was substantially greater in the group of anorexia patients as compared to healthy controls. The overall skin conductance level (SCL) was lower in anorexia patients. Increase in SCR during mirror exposure, as opposed to exposure to neutral stimuli, was positively related to the tendency to experience negative emotions, interoceptive sensitivity, body dissatisfaction and suppression, but not to other symptoms of eating pathology or emotional awareness. Apost hocanalysis suggested that physiological reactivity might be associated with interoceptive sensitivity to mirror exposure especially in anorectic patients.Conclusion:The study seems to demonstrate some degree of dissociation between psychophysiological reactivity and subjective response to body exposure in patients with restrictive anorexia. Factors affecting differences in psychophysiological responsiveness to body exposure in anorectic patients require further exploration.
Fibromyalgia in Health Care Worker During COVID-19 Outbreak in Saudi Arabia
Authors: AlEnzi Fahidah , Alhamal Sara , Alramadhan Maryam , Altaroti Ahmed , Siddiqui Intisar , Aljanobi Ghada 
Published: September 2021

Background: In the face of the contemporary COVID-19 pandemic, health service providers have emerged as the most at-risk individuals who are likely to contract the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Aim: To measure the prevalence of fibromyalgia (FM) during COVID outbreak among health workers in Saudi Arabia using FiRST and LFESSQ tool.Methods: The study employed a cross-sectional methodology to explore the prevalence of Fibromyalgia among health workers at different health care settings in Saudi Arabia. The assessment of the prevalence of fibromyalgia among health worker was determined by using the Fibromyalgia Rapid Screening Tool (FiRST) and London Fibromyalgia Epidemiological Study Screening Questionnaire (LFESSQ) questionnaires. Descriptive statistics were used to summarize the data.Results: The sample size included 992 participants. The prevalence of fibromyalgia using FiRST and LFESSQ was 12.6 and 19.8%, respectively. In this study, the prevalence of fibromyalgia was higher in females when compared to males. Most of the respondents have Vitamin D deficiency. The relationship of fibromyalgia was significantly associated with the participants who worked during an outbreak, who covered COVID-19 inpatient, covered in-hospital on call and in area quarantine.Conclusion: The study's findings demonstrate that the prevalence of Fibromyalgia among health service providers during the current COVID-19 pandemic is considerably higher and that there are potential interventions that may be employed to mitigate the prevalence of the infection during the COVID-19 crisis.