bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult onset stills disease: Newly diagnosed in pregnancy with rare clinical presentation as pleural effusion
Authors: Shah Garima , Shah Bikram 
Published: November 2021

Adult onset Still’ disease (AOSD) is a rare inflammatory disease which involves multiple systems and is of unknown etiology first described in 1971.It has more prevalence among young females and few studies show the exacerbation of symptoms during pregnancy. Patients usually presents with high grade fever, arthritis, arthralgia, salmon pink rash, organomegaly, lymphadenopathy but rarely can present with pleural symptoms, cardiac symptoms. Several criteria’s are used for diagnosis but Yamaguchi’s has the highest sensitivity of 93.5%. Yamaguchi’s classification criteria includes major and minor criteria’s and exclusion criteria’s. Although diagnostic criteria are there but AOSD till date is a diagnosis of exclusion. All the causes of clinical symptoms should be excluded which involves malignancies, infections, inflammatory conditions, autoimmune diseases before the diagnosis of AOSD is made. A 26-year-old female with G2P0010 and POG 6 weeks presented to medicine OPD with high grade fever associated with chills and rigors from 1 week. She was also complaining of stiffness and pain in multiple joints with chest pain, easy fatigability. She was having rashes on upper back below nape of neck. All the necessary investigations were carried out. It was found that she was also having right sided pleural effusion and severe microcytic hypochromic anemia. After batteries of investigations and consultation by obstetrician, rheumatologist, dermatologist diagnosis of Adult Onset Still’s disease was made. It was a diagnosis of exclusion. Patient was started on steroids and she responded well. All the symptoms including pleural effusion was subsided. Adult onset still’s disease is a form of still’s disease. It is a rare systemic auto-inflammatory disease. Yamaguchi is the most sensitive criteria but till date it is diagnosed after excluding possible causes of malignancies, infections and autoimmune conditions. Sometimes patients do present with rare symptoms like pleural effusion, pericarditis some may present as acute respiratory distress syndrome or mild symptoms like cough, pleuritic chest pain. In our case also all the possible causes were excluded as patient presented with pleural effusion for the first time during pregnancy, so the impact of the disease on the fetal outcome was also considered. AOSD has always been a diagnosis of exclusion but as in our case and cases with similar presentation AOSD should be consider as a differential diagnosis. Although there are only few studies which shows that there is fatal outcome of pregnancy in AOSD however there are studies showing exacerbation of symptoms of AOSD during pregnancy. Its early diagnosis and prompt treatment can be helpful in the better outcome of pregnancy as well as better prognosis of disease.
Clinicopathological study of male breast lesion at a tertiary care in western India (Maharashtra)
Authors: Rathod Kalpana Baliram , Gaikwad Manish J , Chaudhari Anita , Nakate Leena A 
Published: November 2021

Male breast cancer is a rare disease compared to female breast cancer. The reason of the low incidence rate in men is the relatively low amount of breast tissue along with the difference in their hormonal environment. Even though breast tissue is less in men as compared to women, the factors that influence malignant changes are similar. The rare nature of disease and lack of surveillance system for male breast cancer it makes a difficult disease to study. Present study was carried out to understand clinipathological features of male breast lesions.A retrospective descriptive study was carried out in a tertiary care center for 5yeras duration (Jan 2014 to Dec 2018) at pathology department. Demographic, history and histopathological details of male breast lesion were retrieved from database at pathology department.Median age of cases was 58.34+6.67yrs and range of 54-80years. Very few had family history of breast cancer. Alcoholism, obesity and chronic liver disease were risk factors. Most of them were diagnosed as gynecomastia on histopathology findings. One case of phylloid tumor.Changing lifestyle and environmental condition may rise MBC in the future, understanding epidemiology and pathology is need of time for early diagnosis and management.
Histopathological study of benign breast lesions
Authors: Janaki M , Poojasree R , Kumar M Anil , Kumar A Hareesh , Nagachandana T 
Published: November 2021

Benign breast lesions are common in young females and are painless. Fibroadenoma is the commonest lesion among all the breast lesions and occurs in any age.1:To study the age and sex wise distribution of benign breast lesions; 2: To study the clinicopathological changes of benign breast diseases; 3: To study different types of benign breast lesions; 4. To study the histomorphological changes of benign breast lesions with clinical correlation.A prospective study of two years was done to evaluate the different types, patterns of benign breast lesions in females in relation to age, clinical and radiological features.A total of 140 benign breast diseases were studied. Fibroadenoma (76; 54.2%) was the most common lesion noted in younger females (18-24yrs) followed by fibrocystic disease (25; 17.8%) & benign phyllodes (14; 10%).FNAC followed by histopathological examination were the diagnostic criteria used for confirmation of the lesions.Benign breast lesions were common in young females, presented with painless, mobile breast lumps. Mastalgia and nipple discharge were other symptoms.
Follicular cholecystitis with cholelithiasis – A diagnostic pitfall
Authors: Pol Jaydeep N , Bhosale Neha M , Patil Mahendra Atmaram , Pol Vaishali J 
Published: November 2021

Follicular Cholecystitis (FC) is an extremely rare subtype of Chronic Cholecystitis (CC). It is characterized by hyperplastic lymphoid follicles along with prominent germinal centers. It constitutes about 2% of routine cholecystectomies. In this article, we report a case of FC in a 69 years lady. She had abdominal pain, clinically diagnosed as Calculus cholecystitis and managed by laparoscopic cholecystectomy. Grossly, thickening of the gall bladder wall was noted. Histopathological examination revealed gall bladder wall infiltrated by dense lymphoid infiltrate forming lymphoid follicles with prominent germinal centres. Hence, we rendered a diagnosis of FC. The purpose of presenting this case is to make pathologists aware about this entity. One should not mistake this lesion for lymphoma. A careful histopathological examination is diagnostic and Immunohistochemistry may be helpful in difficult cases.Follicular Cholecystitis is extremely rare variant of Chronic cholecystitis. It is characterized by at least 3 Lymphoid Follicles per cm of Gall Bladder tissue with inflammatory infiltrate composed almost exclusively of scattered well-formed Lymphoid Follicles. Pathologist must be familiar with this entity to avoid misdiagnosis of lymphoma.
University in an oil-dependent state economy: The future of Khuzestan higher education
Authors: Farhadi Rad Hamid , Farazmand Hasan , Afghah Morteza , Andayesh Yaghoob 
Published: November 2021

Purpose of the study: The understanding of the complex world and the ability to imagine the futures is the basis for planning and decision-making. Therefore, in this research, the possible future of university in an Iranian oil-dependent economy is studied, and, the best direction for higher education in Khuzestan province is explored. — Methodology: A formative scenario writing research method is used in the current study. The participants were recruited from among Iranian higher education experts purposefully; a series of in-depth interviews including personal and focus group interviews have also been conducted to reach saturation. —Main findings: The results of the present research showed that two main factors affect Khuzestan higher education: dependency on the state economy and increasingly growing social expectation from the university. Khuzestan universities have better select one of these orientations: Conservative University, Enabler University, Adaptive University, and Developmental University. According to the findings of the study, developmental orientation is the preferred scenario for Khuzestan higher education. — Applications of this study: It is argued that the developmental university is the preferred scenario for the future of higher education in Khuzestan Province and a proposal suggests its actualization. — Novelty/originality of this study: The applied scenario-based innovative research attempts to reveal the socio-economic role of universities in societies having State-Economy such as Iran, shows all the possible main paths, and finally determines the preferred path for a specific period of time. The current probe can be directly used to lead higher education policymakers of the province and be indirectly employed to help individuals adopt general orientations in higher education, as well as students and researchers who are interested in higher education studies, especially in the field of Higher Education (HE) public policymaking. Finally identified and explained the developmental university that is compatible with Khuzestan higher education situations is another novelty of this research.
Received: 29 March 2021Accepted: 21 June 2021
Unsur Keteladanan Tokoh dalam Buku Digital H.B. Jassin: Perawat Sastra Indonesia sebagai Bahan Ajar Bahasa Indonesia
Authors: Etikasari Dian , Mulyaningtyas Rahmawati 
Published: November 2021

The younger generation possess problems in recognizing the national figures who have contributed greatly to the Indonesian nation. The Ministry of Education and Culture by its digital library releases the site budi.kemdikbud.go.id which provides the books that are very useful for children in recognizing Indonesian national figures. One of the books is entitled H.B Jassin: Perawat Sastra Indonesia which contains about the ins and outs of H.B Jassin that gives a great role model. This can be used as a role model for children in building their character development. In addition, the digital book H.B Jassin: Perawat Sastra Indonesia can be used as a teaching material for Indonesian language learning. The purpose of this research is to describe the noble attitude of H.B Jassin and the use of the digital book H.B Jassin: Perawat Sastra Indonesia as Indonesian language teaching material. Descriptive qualitative was chosen as the research method an digital book H.B Jassin: Perawat Sastra Indonesia as the source data. From the results of the analysis, it was found that the noble character elements of H.B. Jassin, they are fond of reading, passionate and brave, confident, devoted to parents, respectful, diligent and thorough, honest and responsible, persistent, charitable, humble, simple, patient, forgiving, creative, hardworking, religious, and nationalist person. Then, the digital book H.B Jassin: Perawat Sastra Indonesia is used as a teaching material for Indonesian language learning at the high school level in grade X at basic competencies 3.14 menilai hal yang dapat diteladani dari teks biografi.
Neoproterozoic Deposits of the Bashkir Mega-Anticlinorium (Southern Urals): State of the Art in Regional Stratigraphy
Authors: Dub S.A. 
Published: November 2021

Abstract—This paper presents an alternative variant of stratigraphic subdivision of the upper Riphean–Vendian deposits (approximately corresponding to the Neoproterozoic Erathem of the International Chronostratigraphic Chart (ICC)) of the Bashkir Mega-Anticlinorium (BMA), based on the modern concepts of changes in the biosphere, atmosphere, and hydrosphere (and, accordingly, in the climate and the course of sedimentary processes) in the period ~1000–540 Ma, with regard to the results of recent studies and the proposals for improving the Russian General Stratigraphic Scale (GSS) of the Precambrian. The strict necessity of subdividing chronostratigraphic and lithostratigraphic units is shown. The presented data give grounds to regard the Zil’merdak Formation as a Group and assign three of its lower formations to the Middle Riphean (Yurmatinian). It is shown that the period of accumulation of the Karatau Group (comprising the Katav, Inzer, Min’yar, and Uk formations) was significantly shorter than the duration of the Late Riphean (Karatavian). Special attention is focused on the age of the Uk Formation (analysis of the existing data made it possible to refine its stratigraphic position): It formed, most likely, in the period 780–740 Ma. A high uncertainty of the stratigraphic position of the overlying geologic bodies is demonstrated. The Bakeevo, Tolparovo, Suirovo, and Kurgashla formations must be regarded as part of the Terminal Riphean (Arshinian). The Arsha Group, comprising the Bainas, Makhmutovo, Igonino, and Shum formations in the Tirlyan trough and represented by the Krivaya Luka Formation in the Krivaya Luka syncline, should not be totally assigned to the Terminal Riphean. It is proposed to exclude the Bakeevo Formation and the Tolparovo–Suirovo sequence from the Asha Group, because these deposits are, most likely, a modification of the Arsha Group located on the western flank of the BMA. The Uryuk Formation is probably of pre-Vendian age. The current contradictory data on the stratigraphy of the supra-Uryuk unit of the Asha Group are interpreted. The ages of the geologic bodies composing the Group and its stratigraphic interval still call for a thorough study.
Optimising Depth Selection on Section Milling Operation to Secure Sustained Casing Pressure During Plug and Abandonment Operation
Authors: Wangsamulia Dianita , Pahlevi Khresno , Paulus Simon , Aditya Gama , Tanjung Heri , Dewanda Ratna 
Published: November 2021

Abstract
D-01 was an exploration well requiring a Plug-and-Abandonment (P&A) procedure with sustained casing pressure up to 2,000 psi on the B annulus. The presence of Sustained Casing Pressure (SCP) is one of the major technical challenges to decommission and abandon the well safely. Several attempts to secure the well using the perforation-and-squeeze method were performed – but failed. It was decided to perform section milling operations to create a viable rock-to-rock barrier. In this operation, the key factor in determining success, is selecting the correct depth to mill safely and secure the annular pressure source.
A comprehensive approach was taken to determine the optimum depth for the section milling by evaluating existing open-hole and cased-hole data. Additionally, triple-detector Pulsed Neutron Log (PNL) was also performed prior to the section milling operation. The triple-detector PNL tool offered not only behind casing porosity (TPHI) and sigma (SIGM) measurement, but also a relatively new measurement in the oil and gas industry called Fast Neutron Cross Section (FNXS), which were expected to provide more accurate gas detection and gauge the condition near the borehole. By combining all the logs and reservoir data, the milling interval was selected and the section milling and subsequent cement plug operations were performed.
Evaluation of existing open-hole and cased-hole logs provided geological and petrophysical insights which were useful in determining the hydrocarbon source charging the B-annulus. Further analysis on PNL data provided indication of possible gas pockets in the B-annulus. This information was used to distinguish between shallower formation sources or gas pockets that were not yet bled off. The operation on D-01 successfully resolved the B-annulus issue and the well was properly abandoned per regulatory requirements.
Considering the complexity and high cost of section milling operations, a thorough review of data and pre-job logging increases the probability of selecting the optimum intervals needed to successfully complete P&A operations on SCP wellbores.
Case Study and Lessons Learnt for the 1St Fully Integrated Hwu Well Abandonment at Field a Offshore Malaysia
Authors: Shahril Shahril Yang Shahril , Tengku Khairul Tengku Khairul Izwan Tengku Ahmad Tengku Khairul , Khalieff Khalieff Fathiee Lokman Zakey Khalieff Fathiee 
Published: November 2021

Abstract
Uzma was awarded with 1st integrated well abandonment under Provision of Well Abandonment Integrated Services (WAISE) in 2018. Total of 22 wells were plug & abandonment with average 10 to 20 days per well were spent to complete the work. The scope of works is inclusive providing Project Management Team, Hydraulic Workover Unit, Accommodation Work Boat, Supply Vessels, and P&A services.
This paper will highlight the practical experiences and capture the lessons learned obtained executing 1st integrated well abandonment campaign in Field A Offshore Malaysia. This paper presents the overall project lesson learnt for 1st integrated well abandonment embarked from early stage of project planning, preparation, acceptance, technical, operation & project close out. The lesson learnt will be beneficial for all Operator & Contractor Company involving with integrated well abandonment. This paper also presents capability of hydraulic workover unit and recommendation for future of low-cost well's plug and abandonment.
Plug and abandonment operations with conventional hydraulic workover units have an enormous impact on low-cost plug and abandonment campaign in Malaysia compared with conventional drilling rigs. In essence, the lessons learned and insights gained throughout abandonment campaigns will keep accumulating with time to feed into the knowledge and experience vault. With proper project lesson learnt, many success cases and best practices can be emulated both from technical and commercial point of view. This lesson learnt will be beneficial for all Operator & Contractor Company involving with integrated well abandonment.
General Practitioners’ Perspectives Over Solutions To Change BZD Prescription Trends – A Qualitative Study
Authors: Reis Teresa , Serra Helena , Faria Inês , Xavier Miguel 
Published: November 2021

Abstract
Background: This qualitative study explores General Practitioners’ (GPs) perspectives on solutions to address the problem of excessive prescription of benzodiazepines (BZDs). Over-prescription of BZDs at a primary health care settings is a prevalent issue in the region under analysis, but also elsewhere internationally. GPs are the gatekeepers to these medicines in primary care, but for several subjective, organizational and external reasons, they find it difficult to change current prescription patterns. Simultaneously, GPs recognize the issue of BZD excessive prescription practices, and propose possible solutions to invert the trend.Methods: Qualitative data were collected in seven primary health care centers in an interior and mostly rural region of Portugal. We conducted 12 semi-structured interviews with GPs. Interviews were audio-recorded, transcribed verbatim and underwent thematic analysis. The themes were integrated and organized into eight axes for action.Results: Solutions proposed by GPs focused on organizational aspects, such as human resources, infrastructure and training (including on withdrawal schemes), alternative approaches, and wider community-based initiatives to counter societal aspects affecting mental health in the identified region. The themes were integrated and organized into eight axes for action.Conclusions: The findings provide an assessment of the priorities to change excessive BZDs prescription, as suggested by the GPs in primary health care settings, and hence reflecting what they consider to be context specific needs. Both experts and multi-stakeholders bottom-up perspectives should be taken into account when proposing new policies and local strategies to tackle current excessive BZD prescription, especially considering the failure of previous strategies to change this well-known public health issue. We consider that our results to be generalizable to all countries where primary health care plays a central role in care provision.Trial registration: ClinicalTrials.gov number NCT04925596
Human Serum Albumin Aggregation and its Modulation Using Nanoparticles: A Review
Authors: Paramasivam Santhosh , Kundal Kavita , Sarkar Nandini 
Published: November 2021

:
Amyloid fibrils are highly stable protein fibrillar aggregates believed to be involved in
various neurodegenerative diseases, which include Alzheimer’s disease, Parkinson’s disease, and
prion diseases. Inhibiting the aggregation process is a potential strategy to prevent diseases caused
by amyloid formation. In this regard, nanoparticles have emerged as promising candidates owing
to their unique physical/chemical properties of small size, large surface area, biocompatibility,
biodegradability, non-toxicity, and ease of functionalization. Human Serum Albumin (HSA) is a
soluble multidomain monomeric protein that interacts with various ligands and hormones, aiding in
their transport, distribution, metabolism in the circulatory system, and also plays a vital role in extracellular
fluid volume stabilization. Under certain in vitro conditions, HSA has been reported to
undergo conformational changes leading to fibril formation and hence acts as a suitable model for
studying amyloidogenesis. In this review, we have explored the effects of various nanoparticles on
HSA aggregation and their mechanism of action. The study will throw light on the mechanistic details
of nanoparticle-mediated amyloid modulation, which will help in the development of effective
therapeutics against amyloidosis.
Biophysical Insight into Protein Folding, Aggregate Formation and its
Inhibition Strategies
Authors: Zakariya Syed Mohammad , Zehra Aiman , Khan Rizwan Hasan 
Published: November 2021

:
The failure of protein to correctly fold into its functional and unique three dimensional
form leads to misfolded or partially folded protein. When these rogue proteins and polypeptides escape
the quality control mechanism within the body, they result in aberrant aggregation of proteins
into characteristic amyloid fibrils. This is the main cause for the number of neurodegenerative diseases,
including Alzheimer’s disease, Parkinson’s and Huntington’s diseases. This review aims to
summarise the underlying mechanisms of protein folding, misfolding and aggregation. It also highlights
the recent technologies for the structural characterisation and detection of amyloid fibrils in
addition to the various factors responsible for the aggregate formation and the strategies to combat
the aggregation process. Besides, the journey from origin to the current scenario of protein aggregation
is also concisely discussed.