bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge management enablers and innovative capabilities: the mediating role of knowledge transfer—insights from telecom industry in Egypt
Authors: Hameed Marwa Mohamed Abdel , Hashem Abd Elazez Abd Eltawab , Ali Tarek Mohamed 
Published: February 2025

Abstract

Purpose
This study aims to investigate the mediating role of knowledge transfer (KT) in explaining the interdependencies between Knowledge Management Enablers (KMEs) and Innovation Capabilities (ICs) within Egypt’s Telecom industry.

Design/methodology/approach
Using a cross-sectional survey, the authors collected data from 315 employees working at the leading four Telecom Companies in Egypt. The hypothesized model was analyzed using the partial least square structural equation modeling technique. Semi-structured interviews were conducted with 40 key positions and mirrored against the quantitative data. The qualitative data were analyzed using the thematic analysis technique.

Findings
The results indicate a significant positive effect of the KM enablers of T-shaped skills and leadership-style on workers’ ICs. The KMEs dimensions of organization culture, structure, IT-Support-T-shaped skills and leadership-style explain the KT mechanism. The relationship between the KM enablers of (organization culture, structure, IT-Support, and leadership-style) and workers’ ICs is mediated by the KT mechanism. The relationship between T-shaped skills and ICs is not mediated by KT.

Research limitations/implications
Limited attention, until now, is given to the KMEs, KT and ICs interdependencies. This study bridges this research gap by exploring how KM enablers (i.e., organization culture, organization structure, IT infrastructure, T-shape skills, and leadership-style) shape the mechanism of transferring knowledge within the organization, which generates ICs for organizations operating in dynamic environment.

Practical implications
The results provide managers with applicable recommendations for fostering KMEs, encouraging KT mechanisms, and enhancing workers’ ICs.

Originality/value
This research is among the first to significantly contribute to understanding how KT mechanism, as mediator, explain the interdependencies between KMEs and ICs in ever-changing business environment.
Sacroiliitis and endocarditis in the absence of fever: an unusual clinical presentation following diarrhea in a young patient
Authors: Kiskani Amin Karimzadeh , Hassanaghaei Tarlaan , Banestani Nazanin Sanjari , Salajegheh Faranak , Rukerd Mohammad Rezaei Zadeh , Ziaadini Bentolhoda 
Published: February 2025

Abstract
We present a case of a 23-year-old woman who developed afebrile left-sided sacroiliitis and tricuspid valve endocarditis caused by Staphylococcus aureus, one week after experiencing a bout of diarrhea. The patient presented with bilateral lower extremity weakness and left sacroiliac joint pain, without fever. Diagnostic workup, including laboratory tests, imaging studies, and synovial fluid analysis, confirmed the diagnosis of S. aureus septic arthritis. The patient subsequently developed tricuspid valve endocarditis, diagnosed by transthoracic echocardiography. Management involved a prolonged course of intravenous clindamycin, as the patient had an allergic reaction to vancomycin. This case highlights the importance of considering infectious etiologies in patients presenting with musculoskeletal complaints, even in the absence of fever, and underscores the potential for hematogenous spread of infection from one site to another. Further research is needed to elucidate the pathophysiological mechanisms underlying afebrile presentations of serious infections and to identify risk factors for atypical clinical manifestations.
Adverse effects of oral glucocorticoid therapy - a brief review of literature
Authors: Gruszka Marta , Polańska Paulina , Kubicka Maria , Zakrocka Martyna , Fick Jakub 
Published: February 2025

Introduction and Objective: Glucocorticoids (GCs) are among the most commonly prescribed pharmaceuticals across various medical specialties. The purpose of this article is to provide an overview of the most common side effects of oral glucocorticoid therapy and to underline the importance of educating healthcare professionals and patients on this topic.
State of knowledge: Glucocorticoids are commonly used in a wide range of patients because of their anti-inflammatory and immunosuppressive properties. Oral glucocorticoids can lead to a greater number of side effects in comparison with other routes of administration due to their systemic action. Adverse effects of glucocorticoid therapy involve endocrine, cardiovascular, musculoskeletal and central nervous systems. Patients often present with elevated serum glucose levels caused by reduced insulin sensitivity and amplified hepatic glucose production. Moreover, hyperglycemia and hypertension increase the risk of ischemic heart disease and heart failure. GCs impede bone formation and escalate bone resorption, resulting in bone mass reduction and osteoporosis. Myopathy may occur as a result of intensified catabolic processes. Glucocorticoid therapy impacts the production of cortisol by the adrenal glands and can lead to adrenal insufficiency and even adrenal crisis. Characteristic changes in external appearance aggravate self-esteem and mental health of patients resulting in decreased quality of life. Another adverse effect described in literature is substantial cognitive decline.
Summary: Despite their multiple positive applications, glucocorticoids are associated with numerous side effects. It is imperative for medical professionals to ascertain that the disadvantages do not outweigh the advantages of glucocorticoid therapy. Further research is needed to ensure that patients are provided with the best possible care.
Differential diagnosis of gout and tenosynovial giant cell tumor, a case report
Authors: Pyatnitskaya P. I. , Otteva E. N. , Polukhina E. V. 
Published: February 2025

Gout is the most common inflammatory joint disease, related to microcrystalline arthritis. With improper or inadequate treatment, gout can lead to disability.A patient with a misdiagnosis of tophaceous gout is described in whom a differential diagnosis with a neoplasm was performed. As a result of the additional examination, a giant cell tenosynovial tumor of the second finger of the right hand was discovered.
Experience of using the interleukin-6 inhibitor olokizumab in patients with rheumatoid arthritis in real-life clinical practice (based on data from Tyumen Regional Rheumatology Center)
Authors: Patrikeeva I. M. , Lushpaeva Yu. A. , Knaub N. V. , Ustinova E. A. , Belikov O. A. , Dolgikh M. B. , Malysheva T. Yu. 
Published: February 2025

The Tyumen Regional Rheumatology Center has gained experience in the use of the interleukin-6 inhibitor olokizumab (OKZ) in the treatment of patients with rheumatoid arthritis (RA).Objective: to evaluate the efficacy and safety of OKZ therapy in patients with RA in real-life clinical practice.Material and methods. The analysis included 75 patients with a confirmed diagnosis of RA who were prescribed OKZ at a dose of 64 mg every 4 weeks. All patients underwent a standard clinical and laboratory examination and concomitant diseases were recorded. The results were evaluated after 1, 6 and 12 months of therapy. A retrospective evaluation of radiological outcomes was performed in 20 patients who had received OKZ for at least 1 year.Results and discussion. After only one month of OKZ treatment, the proportion of patients with high RA activity according to DAS28-CRP decreased statistically significantly from 81% to 53.3%. After 6 months, 55 (73.33%) of 75 patients continued OKZ therapy, and most of them (74.55%) achieved the stage of drug remission, while high RA activity was not detected. After 12 months, 43 (57.33%) of the 75 patients continued OKZ therapy, with low activity and remission observed in 16.2 and 69.8% of them, respectively. During these periods, there was no radiological progression of RA against the background of OKZ therapy. Ten patients (13.33%) discontinued OKZ therapy due to insufficient efficacy, 2 (2.67%) due to pregnancy, 14 (18.67%) due to adverse events and 6 (8%) for other reasons.Conclusion. In real-world clinical practice, OKZ showed significant therapeutic potential and a favorable safety profile in patients with RA.
Chronic pain and group B vitamins
Authors: Zonova E. V. , Alekseeva L. I. , Lila A. M. 
Published: February 2025

Chronic pain (CP) impairs quality of life and increases the risk of non-communicable diseases and mortality. Pain is variable, and different mechanisms of its development determine the tactics of patient treatment. Researching pathogenesis of different types of pain can serve as a prerequisite for the development of more effective treatment approaches. The introduction of drug combinations into clinical practice enables a better response to treatment with lower doses, thereby reducing drug burden and potential toxicity.The review presents studies that address the question of how the efficacy of chronic pain therapy can be increased by including adjuvants in the treatment regimen, particularly a vitamin B complex.
Numerical investigation of inlet pressure effects on condensation flow regime in a supersonic nozzle
Authors: Qian Yu 
Published: February 2025

Abstract
Non-equilibrium condensation (NEC) is a prevalent phenomenon in various industrial equipment, and it can substantially affect their operational efficiency and overall performance. Droplet nucleation and growth is one of the important aspects of NEC and needs to be investigated and studied, whatever affects these parameters. On the other hand, NEC has a considerable impact on the flow pattern and condensation shock causes a sudden change in flow parameters. This study has been conducted with the aim of investigating the impact of inlet pressure (IP) on the flow pattern and two-phase flow parameters. The values of 90 kPa, 95 kPa, 99.98 kPa, 105 kPa, and 110 kPa are considered as the nozzle IP for this investigation, and its impact on the parameters of pressure, temperature, speed, density, droplet radius, liquid mass fraction (LMF), nucleation rate, Number of drops and condensed mass rate. According to the results, as the IP increases, the condensation shock occurs earlier and the LMF in the nozzle increases. As the pressure increases from 90 kPa to 110 kPa, the amount of LMF increases by about 5.7 %, and more LMF is produced in the nozzle. This study provides a good understanding of the impact of IP on NEC.
Traditional Metaphors of Indonesian Women’s Beauty
Authors: Saidi Acep Iwan , Puspitasari Dyah Gayatri , Parung Christabel Annora Paramita , Luzar Laura Christina 
Published: February 2025

Abstract
The aim of this article is to elaborate on the problem of traditional metaphors used to describe the beauty of Indonesian women. The traditional metaphors used to describe the beauty of Indonesian women originate from nature and show specific aspects of beauty, both physically and non-physically. Also, under the modern Western-dominated global beauty discourse and concepts, traditional forms and concepts of beauty are re-elevated and given new value to enrich global knowledge and culture. Through the ethno-semiotic method, the study shows that the traditional forms and concepts of beauty regarding Indonesian women cannot be separated from natural occurrences. Description based on natural objects and phenomena is not just a matter of metaphorical language as a rhetorical means to describe beauty but forms a significant relationship with the natural and cultural characteristics of body beauty. The union of the body and nature creates a powerful energy that positions women as subjects of nature, culture, and social life. This finding allowed for the development of a new discipline – the ecology of beauty.
Computational modelling in liver system and liver disease
Authors: Liao Yunjie , Davies Nathan A. , Bogle I. David L. 
Published: February 2025

Abstract
The liver, our body’s chemical factory, is central to metabolism, homeostasis, and detoxification. The advent of systems biology and computational modelling has revolutionised our understanding of the liver system and its diseases. This chapter focuses on the application of computational modelling, specifically a kinetic model of fructose metabolism, to explore the relationship between fructose and liver disease progression. We begin by reviewing the fundamental aspects of liver anatomy and physiology, setting the stage for an in-depth discussion on the alarming crisis of metabolic dysfunction-associated steatotic liver disease (MASLD). Through a specific case study, we provide insights into the metabolic events triggered by fructose intake and illustrate how computational models can predict disease progression and identify potential therapeutic targets, paving the way for personalised treatment plans. The chapter concludes by discussing the challenges and future directions in the field, emphasising the transformative potential of engineering principles in medicine.
Macroscopic transport models for drugs and vehicles in cancer tissues
Authors: González-Garcinuño Álvaro , Tabernero Antonio , Martín del Valle Eva 
Published: February 2025

Abstract
Modeling drug release in solid tumors is a convergence point between chemical engineering and medicine. Consequently, many studies have been conducted to unravel the mechanisms behind drug distribution after administration. In addition, several approaches have been explored, ranging from pharmacokinetic and pharmacodynamic models to microscopic transport models through macroscopic transport models. This chapter focuses on the latter, macroscopic transport models, and discusses how these models can predict the processes involved in drug delivery, in free form or vehicle transported. We start by presenting some of the differentiating physiological parameters in cancer tissues and then the main equations used for modeling, including fluid flow, mass transport, and cell uptake. Also, the use of some dimensionless parameters explaining the processes that control transportation will be examined. Lastly, the final section will explore the process employed for building geometries to simulate solid tumors, as well as current research being conducted on patient-specific simulations made using medical images.
ТРАНСФОРМАЦИЯ ГОРОДСКОГО ПРОСТРАНСТВА ИРКУТСКА В КОНТЕКСТЕ СОВРЕМЕННЫХ УРБАНИЗАЦИОННЫХ ПРОЦЕССОВ
Authors: ВОРОБЬЕВ А.Н. , ОПЕКУНОВА М.Ю. 
Published: February 2025

Представлены результаты комплексного анализа динамики рельефа и населения ключевого участка - Академгородка г. Иркутска - в нижнем бьефе Иркутской ГЭС за последние пять лет. Использованы разновременные геоизображения, включая аэрофотосъемку, космические снимки и топографические карты, базы данных свободного доступа OSM, кадастровые базы, а также маршрутные наблюдения. Анализ таких данных позволяет оперативно оценить динамику морфологии рельефа и изменения структуры проявления экзогенных процессов, плотности населения. На основе полученных данных было отмечено изменение застройки территории исследования, потенциальное изменение плотности населения. Результаты исследования показывают изменения морфотипов застройки, связанные с увеличением плотности населения, нагрузки на объекты инфраструктуры, дорожную сеть и сети инженерно-технического обеспечения способствуют развитию негативных и опасных геологических процессов, что повышает эколого-геоморфологическую напряженность в данном конкретном месте. Очевидно, что в результате неграмотного планирования городской среды, без расчета антропогенной нагрузки могут возникнуть неблагоприятные условия, влияющие на устойчивость геоморфосистемы.
The article presents the results of a comprehensive analysis of the relief and population dynamics of the key site - Akademgorodok of Irkutsk - in the downstream of the Irkutskaya HPP over the past five years. We used multi-temporal geo-images, including aerial photography, space images and topographic maps, free-access OSM databases, cadastral databases, as well as route observations. The analysis of such data allows us to promptly assess the dynamics of the relief morphology and changes in the structure of manifestation of exogenous processes and population density. Based on the data obtained, a change in the built-up area of the study territory, and a potential change in population density were noted. The results of the study show that changes in the morphotypes of development associated with an increase in population density and the load on infrastructure facilities, road network and engineering networks favorably affect the development of negative and dangerous geological processes, which increases the ecological and geomorphological tension in this particular place. It is obvious that as a result of illiterate planning of urban environment, without calculation of anthropogenic load, unfavorable conditions affecting the stability of the geomorphosystem may arise.
Galectin-10 Characterization in Cleft Lip Palate – Affected Palatal Tissue
Authors: Rone Alise Elizabete , Pilmane Mara 
Published: February 2025

Background. Cleft lip palate is one of the most common craniofacial birth defects in humans. Multiple defense factors have been described to have possible involvement in the failure in palatal shelve elevation, migration and fusion, most importantly, the role of chronic inflammation. A widespread presence of Gal-10 in different local inflammatory processes has been discussed before, however, knowledge of its involvement in local tissue inflammation in the postnatal cleft palate and tissue regeneration is scant. This study focuses on the detection of appearance and a possible role of Gal-10 in the cleft-affected facial tissue regarding its ontogenetical aspect.Materials and Methods. Craniofacial cleft tissue material was obtained from 21 children aged 8 months to 12.7 years undergoing veloplastic or uranoplastic procedure with non-syndromic craniofacial cleft diagnosis in milk or mixed dentition. Control groups for milk dentition were 5 subjects without orofacial defects for milk dentition and 3 subjects with plastic of superior lip frenula for mixed dentition. The number of factor positive cells in the control group and the patient group tissue was evaluated by using the semiquantitative counting method. The data were evaluated with the use of nonparametric statistical methods.Results. Elevated levels of Gal-10 were found in the epithelium in correlation with age, from milk to mixed dentition, as well as in both the control and the patient samples. Notable differences in expression can be seen by comparing the milk and the mixed dentition patient muscle tissue, where the milk dentition palate shows a more elevated factor expressed in comparison to the mixed dentition palate.Conclusions. The nearly total absence of Gal-10 in the healthy palate with an increase of its expression in the palatal epithelium from the milk to mixed dentition age of cleft-affected children suggests the possible role of this factor in providing the local defense function and the epithelium barrier function. The palatal muscles are not the main place for Gal-10 expression either in healthy or in cleft condition-affected individuals. The sporadic and insignificant appearance of Gal-10 only in the healthy milk dentition age and the mixed dentition age cleft-affected palatal connective tissue prove individual changes in the palatal tissue which does not depend on the specific disease.
From Fibroadenoma to Phyllodes Tumor: Case Analysis of Borderline and Giant Breast Tumors with Literature Review
Authors: Kazlauskaitė Justė , Schmeil Iryna 
Published: February 2025

Background: Phyllodes tumors are highly uncommon fibroepithelial neoplasms of the breast, accounting for less than 1% of all breast tumors. Differential diagnosis between phyllodes tumors and fibroadenomas by using imaging techniques such as ultrasound or mammography, as well as histological methods, can be challenging due to overlapping features. Phyllodes tumors are categorized into benign, borderline, and malignant types, each posing a different risk of recurrence and metastasis. Despite many advances in the imaging and biopsy techniques, diagnosing phyllodes tumors remains challenging. The purpose of this study is to review the existing literature on this topic and describe two cases of misdiagnosed phyllodes tumors.Materials and methods. A literature review was conducted by using the Medline (PubMed) database over 10 years. Information concerning the patients was sourced from the Uster Hospital database. After analyzing the cases of women with breast lumps from 2020 to 2023 in the Uster Hospital database, two cases of misdiagnosed phyllodes tumors were identified. These two cases were analyzed retrospectively.Results. A retrospective study of two cases confirms that phyllodes tumors are a rare phenomenon. A 51-year-old premenopausal woman presented with an 8 × 4 × 5 cm mass, initially diagnosed as a fibroadenoma. The final histopathology after surgical excision revealed a borderline phyllodes tumor with features overlapping those of a fibroadenoma. The second case involved a 59-year-old postmenopausal woman with a rapidly growing mass, which reached 11.9 × 11.3 cm and was initially diagnosed as a fibroadenoma but later confirmed as a borderline malignant phyllodes tumor with focal malignant components. Both cases highlight the limitations of imaging and core biopsy in accurately diagnosing phyllodes tumors and emphasize the need for comprehensive histopathological evaluation. The described clinical cases corresponded to the characteristics of phyllodes tumors indicated in the literature: they appeared in women older than 35 years, were hard to distinguish from fibroadenomas, and required surgical treatment.Conclusions. Phyllodes tumors are challenging to distinguish from fibroadenomas based on imaging and the initial biopsy results alone. Accurate diagnosis requires thorough histopathological examination following surgical excision. A multidisciplinary approach is essential for optimal management. Our cases show the complexity of phyllodes tumor diagnosis and the importance of considering phyllodes tumors in the differential diagnosis of breast masses, especially when clinical and imaging findings suggest a more aggressive pathology.
Application of Pharmacology Knowledge of General Practice Nursing Students during Clinical Nursing Practices
Authors: Klevinskytė Martyna , Galdikienė Nijolė 
Published: February 2025

Medication errors cause thousands of deaths worldwide every year. Students graduating from the general practice nursing programs will be responsible for the medication administration process, which influences the quality of treatment and care process and the patients’ health. It is of importance for the academic community training nurses to constantly monitor and evaluate the general and clinical pharmacology knowledge of future nurses, strive to present the knowledge as clearly as possible during lectures, practical sessions, and clinical nursing practices, and analyze the most commonly occurring errors, along with their causes, in order to implement the latest teaching methods, and run programs to help avoid any errors. The aim of the study is to determine the application of pharmacology knowledge by general practice nursing students during clinical nursing practices. Research methods: A quantitative study was conducted using the questionnaire survey method developed by the author to collect subject-related data. 120 students of the nursing program were surveyed. Results. The knowledge of second to fourth-year students in the general practice nursing program about nursing actions in the medication administration process is deemed to be sufficient. It has been found that students are well-versed in all stages of the medication administration process. The results of the study suggest that the knowledge and practical skills of the future general practice nurses will allow for quality, professional, and safe nursing care in the future, thereby ensuring better treatment and care process outcomes.