bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indices of connective tissue metabolism, their interconnection in patients with 5D stage chronic kidney disease and in patients with anterior abdominal wall hernias
Authors: Bereshchenko V. V. , Lyzikov A. N. 
Published: October 2021

Objective. To study the interconnection between the indices of matrix metalloproteinases (MMPs) of type I collagen terminal telopeptides in patients with end-stage chronic kidney disease (CKD) and in patients with anterior abdominal wall hearnias.Materials and methods. 39 patients with CKD stage 5D, 24 patients with primary anterior abdominal wall hernias and 25 patients of the comparison group without visual signs of connective tissue dysplasia were included into the prospective study. The concentrations of the levels of MMP-1, MMP-2, MMP-9, tissue inhibitor of metalloproteinase 1 (TIMP-1), TIMP-3, N-terminal telopeptide NTX-N, C-terminal telopeptide CTX-C were determined in plasma using the enzyme immunoassay (ELISA).Results. The end-stage patients with CKD and the patients with anterior abdominal wall hernias showed no statistically signifcant biochemical indices of ongoing bone tissue destruction based on the levels of terminal telopeptides NTX-N and CTX-C. There are statistically signifcant increases in the levels of MMP-1, MMP-2, MMP-9 (p ˂ 0.001) in the CKD stage 5D patients and major TIMP-1 and TIMP-3 (p ˂ 0.001) in relation to the comparison group. These indices were comparable with the changes in the connective tissue of the patients with primary anterior abdominal wall hernias.Conclusion. The obtained results indicate disturbances in the regulation of the synthesis and structural relationships of connective tissue in CKD stage 5D patients and in patients with primary anterior abdominal wall hernias. CKD stage 5D patients and primary anterior abdominal wall hernias reveal identical direct correlations in the indices of connective tissue metabolism according to NTX-N, MMP-1 and MMP-9, TIMP-1, which indicates similar disturbances in the regulation of the synthesis and structural disorders in connective tissue.
Morphological and radiological characteristics of experimental bone tissue regeneration
Authors: Nadyrov E. A. , Nikolaev V. I. , Kirilenko S. I. , Rozhin V. V. , Maltseva N. G. , Veyalkina N. N. , Voisarov V. S. , Voisarova I. A. 
Published: October 2021

Objective.To study the dynamics of reparative bone tissue regeneration in experimental animals using a native transplantation autosmix (NTA).Materials and methods.Male Wistar rats weighing 180–200 g and aged 6–7 months were used. Bone tissue defects were modelled using a cutter with a diameter of 2 mm (experimental group). A similar defect of the middle third of the right tibia was formed in the control group animals without flling the defects with bone tissue. The animals were removed from the experiment on days 3, 7, 14, 30 and 60 of the experiment (per 6 animals for each observation period). The indicators of defect occupancy, necrosis, the area of bone trabeculae, the area of granulation tissue were determined in the histological sections. All the indicators were presented as percentage of the tested area. Osteoblasts, osteocytes, and osteoclasts were calculated in absolute values on the tested area.Results.The study has showed a higher rate of bone tissue formation in the bone defects in the experimental animals after autotransplantation of the bone mixture. Bone recovery in the experimental group had a higher rate, which was manifested by faster flling of the bone tissue defect, a low percentage of the necrosis area, a higher area of bone trabeculae, its rapid transformation into lamellar bone tissue.Conclusion.Osteogenesis had practically completed by day 30 of the experiment. At the same time, in the control group it had completed by day 60. The results obtained are a theoretical precondition for further research in the feld of bone autoplasty. Advanced development of surgical and minimally invasive technologies of bone mixture application will increase the effciency of modern reconstructive surgery of bones and joints.
Determination of the activity of pyruvate kinase isoforms in normal conditions, in toxic liver damage and during the process of its regeneration
Authors: Skuratov A. G. , Lyzikov A. N. , Shaforost A. S. , Zyatskov A. A. , Golubykh N. M. 
Published: October 2021

Objective.To evaluate the activity of pyruvate kinase (PK) isoforms in normal conditions, in toxic damage of the liver and during its regeneration.Materials and methods.An experimental study was carried out on 45 Wistar rats. Toxic liver damage was induced by the intraperitoneal administration of carbon tetrachloride. Mechanical damage was simulated by the surgical resection of the liver. The levels of PK isoforms R/L and M in the blood serum and liver tissue of the laboratory animals were measured with an ELISA test.Results.It has been found that the level of PK isoform M signifcantly increases in chronic toxic liver damage, which may indicate the activation of the processes of liver cell proliferation in response to the damaging effect of hepatotoxin (Mann-Whitney U Test: Z = 2.143; p = 0.032). After liver resection, the level of PK R/L, which characterizes the activation of glycolysis, increased and the level of pyruvate kinase M increased signifcantly, which reﬂected the processes of reparative regeneration in the liver.Conclusion.The serum level of PK isoforms may be used as a laboratory criterion for the activity of reparative regeneration processes, which can be used to evaluate the reparative potential of the liver in case of toxic or mechanical damage, as well as in chronic diffuse diseases.
Occlusion of the vein adjacent to colorectal cancer liver metastasis as a way to increase the radicality of percutaneous radiofrequency thermal ablation
Authors: Murashko K. L. , Yurkovskiy A. M. 
Published: October 2021

Objective.To evaluate the effectiveness of preoperative coagulation of the vein adjacent to a tumor nodule in sonographically-guided percutaneous radiofrequency thermal ablation of perivascular liver metastases of colorectal cancer.Materials and methods.To address the issue, we compared the results of sonographically-guided percutaneous radiofrequency thermal ablation of perivascular liver metastases of colorectal cancer in 27 patients (aged 60.5 (58; 68) years) without prior coagulation of the adjacent vein (control group) and 26 patients (62.0 (60; 74)) with prior coagulation of the adjacent vein (experimental group).Results.Lower incidence of residual tumor in the ablation area in the patients with prior coagulation of the adjacent vein (14.3 % vs. 29 % of the patients in the control group) and a higher relapse-free survival of such patients (65.2 % vs. 53.6 % and 55.6 % vs. 33.3 %) were reported as compared to the group without prior coagulation of the adjacent vein (after 6 and 12 months, respectively).Conclusion.Preoperative coagulation of the vein adjacent to colorectal cancer liver metastasis allows reducing the effect of heat removal from the RFA zone, thereby contributing to higher radicality of the treatment and resulting both in a lower incidence of residual tumor in the ablation zone and a higher relapse-free survivalof patients, notably without signifcant concomitant changes in the affected part of the liver (segment atrophy).
Resultados de supervivencia del cáncer colorrectal metastásico (CCRm) en una cohorte de una práctica en Medellín, Colombia
Authors: Lema Mauricio , Preciado Franco Beatriz Elena , Lema Camila , Romero Millán Ana María , Mora Vélez Sara Paulina , Ríos  Fergusson Mónica Patricia , Quiceno Pareja Diana Marcela 
Published: October 2021

Therapy for mCRC is based on surgery, cytotoxic chemotherapy, and biologic agents. In randomized clinical trials, median progression-free survival (PFS) and overall survival (OS) hover around 10mo and 29mo, respectively. There are no published results on survival outcomes of patients with mCRC in Colombia. Objective: Describe the survival outcomes of patients with mCRC treated by Mauricio Lema in Medellín, Colombia. Methods: This is a retrospective, case series (2008-2020) of mCRC, ≥18 years old, treated with systemic therapy for metastatic disease, and ≥3-month follow-up. Stratification factors included: use of biologic (anti-VEGF or anti-EGFR) plus chemotherapy in 1st-Line (yes/no) and metastasectomy (yes/no). Survival analyses were evaluated using Kaplan- Meier curves. Results from the general population are described, and they are also discriminated against by the use of a biological agent in the first-line of systemic therapy. Results: 89 patients with mCRC were included. The Median follow-up was 35 months (IQR: 21-57). Median PFS and OS were 12.1mo (95%CI: 10.4-13.8) and 29.3mo (95%CI: 23.2-34.4), respectively. Median OS in patients receiving biologics was 28.8mo (95%CI: 22.1 – 35.6) vs 33.7mo (95%CI: 16.4 – 51.0) in the chemo-only group (p=0.01). Median OS in the metastasectomy and non-metastasectomy groups were 36.1 (95% CI: 26.5 - 45.7) and 25.0 months (95% CI: 15.4 - 34.5), respectively (NS). Conclusion: In this case series of patients’ survival outcomes were similar to thosereported in large phase III trials. A small sample size precludes any conclusion as to the impact of biologic agents on survival in this study.
PEMBELAJARAN JARAK JAUH PADA MASA PANDEMI COVID-19 DI SMP NEGERI 2 TARAKAN
Authors: MACHFUD MOCHAMMAD 
Published: October 2021

Penulisan ini bertujuan untuk mengeksplorasi pembelajaran jarak jauh yang dilaksnakan di SMP Negeri 2 Tarakan dapat berjalan dengan baik, agar tujuan pendidikan bisa tercapai. Laporan pelaksanaan Pembelajaran Jarak Jauh merupakan pelaporan hasil pelaksanaan pembelajaran yang dilakukan oleh guru mata pelajaran PPKn kelas 9 di SMP Negeri 2 Tarakan, Kota Tarakan, Kalimantan Utara dalam hal bagaimana penerapan pembelajarannya, menggunakan kurikulum darurat selama pandemi Covid-19, alat dan media apa yang digunakan serta prestasi belajar siswanya Langkah-langkah Langkah seperti meliputi perencanaan pembelajaran, pelaksanaan pembelajaran dan evaluasi, Dari hasil pelaksanaan pembelajaran jarak jauh terdapat beberapa kendala dalam pelaksanaannya akan tetapi bisa diselesaikan dengan baik demi mencerdaskan perserta didik. Baik sistem pembelajaran daring dan luring diharapkan guru dapat kreatif dalam mendidik peserta didik, supaya keberhasilan pembelajaran bisa tercapai dengan baik atau efektif. Penulisan ini memberikan informasi bahwa guru sebenarnya lebih senang memilih pembelajaran luring di mana bisa berinteraksi langsung dengan siswa, dan juga siswa lebih menyukai pembelajaran luring melalui pembelajaran tatap muka. Karena pandemi Covid-19 masih tinggi maka pelaksanaan pembelajaran jarak jauh dengan system daring masih menjadi pilihan alternatif yang terbaik demi keselamatan guru, warga sekolah dan peserta didik itu sendiri.
Assessing the potential efficacy of marine cloud brightening for cooling Earth using a simple heuristic model
Authors: Wood Robert 
Published: October 2021

Abstract. A simple heuristic model is described to assess the potential for
increasing solar reflection by augmenting the aerosol population below
marine low clouds, which nominally leads to increased cloud droplet
concentration and albedo. The model estimates the collective impact of many
point source particle sprayers, each of which generates a plume of injected
particles that affects clouds over a limited area. A look-up table derived
from simulations of an explicit aerosol activation scheme is used to derive
cloud droplet concentration as a function of the sub-cloud aerosol size
distribution and updraft speed, and a modified version of Twomey's
formulation is used to estimate radiative forcing. Plume overlap is
accounted for using a Poisson distribution, assuming idealized elongated
cuboid plumes that have a length driven by aerosol lifetime and wind speed,
a width consistent with satellite observations of ship track broadening, and a depth equal to an assumed boundary layer depth. The model is found to
perform favorably against estimates of brightening from large eddy
simulation studies that explicitly model cloud responses to aerosol
injections over a range of conditions. Although the heuristic model does not account for cloud condensate or coverage adjustments to aerosol, in most realistic ambient remote marine conditions these tend to augment the Twomey effect in the large eddy simulations, with the result being a modest
underprediction of brightening in the heuristic model. The heuristic model is used to evaluate the potential for global radiative
forcing from marine cloud brightening as a function of the quantity, size,
and lifetime of salt particles injected per sprayer and the number of
sprayers deployed. Radiative forcing is sensitive to both the background
aerosol size distribution in the marine boundary layer into which particles
are injected and the assumed updraft speed. Given representative values
from the literature, radiative forcing sufficient to offset a doubling of
carbon dioxide ΔF2×CO2 is possible but would require spraying 50 % or more of the ocean area. This is likely to require at least 104 sprayers to avoid major losses of particles due to near-sprayer coagulation. The optimal dry diameter of injected particles, for a given salt mass injection rate, is 30–60 nm. A major consequence is that the total salt emission rate (50–70 Tg yr−1) required to offset ΔF2×CO2 is a factor of five lower than the emissions rates required to generate significant forcing in previous studies with climate models, which have mostly assumed dry diameters for injected particles in excess of 200 nm. With the lower required emissions, the salt mass loading in the marine boundary layer for ΔF2×CO2 is dominated by natural salt aerosol, with injected particles only contributing ∼ 10 %. When using particle sizes optimized for cloud brightening, the aerosol direct radiative forcing is shown to make a minimal contribution to the overall radiative forcing.
Topo-bathymetric and oceanographic datasets for coastal flooding risk assessment: French Flooding Prevention Action Program of Saint-Malo
Authors: Seyfried Léo , Biscara Laurie , Leckler Fabien , Pasquet Audrey , Michaud Héloise 
Published: October 2021

Abstract. The French Flooding Prevention Action Program of Saint-Malo requires assessment of coastal flooding risks. The first prerequisite is a knowledge of the topography and bathymetry of the bay of Saint-Malo. In addition to existing topo-bathymetric data, the acquisition of new multibeam bathymetric data is performed. The combination of these datasets allows the generation of two high resolution topo-bathymetric digital terrain models. Then, to understand the hydrodynamic conditions which cause coastal flooding, a dense and extensive oceanographic field experiment is conducted. Oceanographic data were acquired using a network of 22 moorings with 37 sensors, during winter 2018–2019. The network included 2 directional buoys, 2 pressure tide gauges, 18 wave pressure gauges, 4 single-point current meters, 7 current profilers and 4 acoustic wave-current profilers from mid-depth (25 m) up to the upper beach and the dike system. The oceanographic dataset provides an overview of hydrodynamics in Saint-Malo bay and wave processes leading to coastal flooding. The combination of high-resolution topo-bathymetric and oceanographic datasets provides a unique capability for model validation and process studies. The topo-bathymetric and oceanographic datasets are available freely at doi : https://doi.org/10.17183/MNT_COTIER_GNB_PAPI_SM_20m_WGS84, https://doi.org/10.17183/MNT_COTIER_PORT_SM_PAPI_SM_5m_WGS84, and https://doi.org/10.17183/CAMPAGNE_OCEANO_STMALO.
Photography, memory, metonymy or, W.G. Sebald’s Vertigo
Authors: Seale Kirsten 
Published: October 2021

The precarious and vertiginous quality of memory is a continuous thread running the extent of W.G. Sebald’s writing. In Sebald’s first novel Vertigo (1990), the attributes of memory are explored through its metonymic relation with photography. Broadly speaking, one of photography’s functions is to metonymically represent memory. For Sebald, however, this metonymy is unreliable and unpredictable. The febrile, fragmented, and ultimately autonomous memories triggered by the metonym are the cause of the vertigo in the title. Sebald’s vertiginous metonymy leads us to Roland Barthes’ notion of the punctum. In his meditation on photography Camera lucida (2000) Barthes explicitly states that the photograph’s punctum performs metonymically. ‘However lightning-like it may be,’ he writes, ’the punctum has, more or less potentially, a power of expansion. This power is often metonymic’ (45). Barthes’ theory provides an analytical framework for understanding Sebald’s aetiology of vertigo and his narrative treatment of the metonymic encounter between memory and photography.
PENGARUH KUALITAS LAYANAN TERHADAP KEPUASAN KONSUMEN RESTO & CAFÉ RUMAH LAUT JAYAPURA
Authors: Risma Risma , Muhyidin Syaiful , Pratiwi Ira Eka 
Published: October 2021

Saat ini, keberadaan kafe dapat ditemukan di mana saja, termasuk di kota Jayapura. Salah satu kafe populer di Jayapura adalah Resto & Café Rumah Laut. Kualitas layanan dipertimbangkan dalam bisnis kafe karena terkait dengan kepuasan konsumen. Pernyataan masalah dalam penelitian ini adalah bagaimana kualitas layanan (bukti fisik, keandalan, tanggapan, jaminan, dan empati) mempengaruhi kepuasan konsumen di Resto & Café Rumah Laut Jayapura. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh kualitas layanan secara parsial dan simultan terhadap kepuasan konsumen di Resto & Café Rumah Laut Jayapura.
Penelitian dilakukan dengan menggunakan model Service Quality (SERVQUAL). Metode penelitian yang digunakan adalah statistik kuantitatif dengan analisis regresi linier berganda. Data dikumpulkan dengan menggunakan kuesioner yang telah diuji validitas dan reliabilitas dari 60 responden Resto & Café Rumah Laut Jayapura.
Hasil penelitian menunjukkan bahwa variabel kepuasan konsumen dapat dijelaskan oleh kualitas layanan sebesar 63,7%, sedangkan sisanya 36,3% dijelaskan oleh faktor lain. Sementara itu, uji f menunjukkan bahwa nilai f-hitung lebih besar dari nilai f-tabel (18,919> 2,38) dengan tingkat signifikansi 0,000 <0,05 berarti bahwa kualitas layanan secara bersamaan memiliki pengaruh yang signifikan terhadap kepuasan konsumen. Selanjutnya, hasil uji-t menunjukkan bahwa bukti fisik dan variabel jaminan secara parsial mempengaruhi kepuasan konsumen, dengan tingkat signifikansi masing-masing adalah 0,048 <0,05 dan 0,009 <0,05. Sementara variabel reliabilitas memiliki tingkat signifikansi sebesar 0,051, variabel respon memiliki tingkat signifikansi sebesar 0,666 dan variabel empati memiliki tingkat signifikansi sebesar 0,098 secara parsial tidak signifikan mempengaruhi variabel kepuasan konsumen.
PERSEPSI NASABAH TERHADAP PROGRAM TABUNGAN RENCANA BERHADIAH PADA BANK MUAMALAT KCP ABEPURA
Authors: Karman Abd , Afifah Nur 
Published: October 2021

Sebagai bank umum syariah pertama di Indonesia, sejak tahun 1992 Bank Muamalat selalu mendapat kepercayaan dari masyarakat sebagai bank yang menyediakan program dan layanan yang berdasarkan prinsip syariah salah satunya program BPS TRB (Bank Penerima Setoran Tabungan Rencana Berhadiah) yang dikembangkan pada tahun 2017 dengan jumlah nasabah secara keseluruhan sejak tahun 2017-2020 adalah 306 nasabah. Rumusan masalah dalam skripsi ini adalah Bagaimana mekanisme program tabungan rencana berhadiah pada Bank Muamalat KCP Abepura dan Bagaimana persepsi nasabah terhadap program tabungan rencana berhadiah pada Bank Muamalat KCP Abepura. Skripsi ini bertujuan untuk menganalisis mekanisme tabungan rencana berhadiah dan menganalisis persepsi nasabah terhadap program tabungan rencana berhadiah pada Bank Muamalat KCP Abepura.
Dalam penelitian ini, penulis menggunakan jenis penelitian kualitatif deskriptif. Data yang didapatkan akan diintrepresentasikan dan dianalisis sehingga menghasilkan sebuah kesimpulan. Data yang diperoleh berasal dari data primer dan data sekunder.Metode observasi, wawancara dan dokumentasi juga dilakukan untuk memperoleh data yang lengkap.
Hasil penelitian ini menunjukkan bahwa mekanisme tabungan rencana berhadiah dilakukan sesuai syarat dan ketentuan yang telah diterapkan, mudah dimengerti oleh nasabah dan akad yang digunakan sesuai syariat Islam yaitu akad mudharabah (bagi hasil) dimana nasabah akan memperoleh nisbah 7,5% setiap bulannya. Persepsi nasabah terhadap program tabungan rencana berhadiah dianggap sangat baik dan menguntungkan, karena program tersebut dapat membantu nasabah untuk mengatur rencana keuangan dikemudian hari dengan tujuan untuk masa depan anak.
Desenvolvimento inicial de mudas de moringa oleífera Lam submetidas a diferentes de substrates
Authors: Silva Wallyson Francisco Lopes da , Nascimento Everton Sebastião do , Avelino João Raphael Lima , Amorim Joan Jobson de Almeida de , Cavalcante Pedro Carvalho Vieira , Santos Nathanyel Ewertthon Alves dos , Santos Denise Maria , Almeida Camila Alexandre Cavalcante de , Pinto Andréa de Vasconcelos Freitas , Leite Maria José de Holanda 
Published: October 2021

O objetivo do trabalho foi investigar qual a melhor concentração de substratos para produção de mudas de Moringa Oleifera Lam, com a finalidade de se obter plantas mais saudáveis, vigorosas e resistentes. O experimento foi conduzido em casa de vegetação na unidade da Embrapa Tabuleiro Costeiro, localizado no Campus de Engenharias e Ciências Agrárias – CECA/UFAL, Rio Largo, AL. Foi realizado o delineamento inteiramente casualizado (DIC) com 7 tratamentos: T0 – 100% solo (testemunha); T1 - solo + 10% de esterco ovino; T2 – solo + 20% de esterco ovino; T3 – solo + 33% de esterco ovino; T4 – solo + 10% de borra de café; T5 – solo + 20% de borra de café; T6 – solo + 33% de borra de café, com cinco repetições, totalizando 35 saquinhos de polietileno, com volume de 3litros, foi utilizada análise de regressão quadrática e cúbica, adotando-se o nível de 5% de significância. Ao contrário do esperado, as mudas produzidas em ambos substratos não apresentam maiores valores. Em relação ao substrato contendo esterco ovino, foi observado que sua utilização em maiores concentrações prejudica sua decomposição e consequentemente a disponibilidade de nutrientes para as plantas. O substrato contendo borra de café, mostrou mais inviável e que sua utilização “in natura” acidifica o solo e torna lenta a mineralização dos nutrientes. Assim é possível recomendar a produção de mudas de Moringa oleifera Lam com substrato de esterco ovino na concentração de 20%.