bluuebunny/crossref_metadata_2025_split huggingface dataset:
REPEATING AND RECURRENCE OF INTENTIONAL MURDER UNDER AGGRESSIVE CIRCUMSTANCES
Authors: Василенко М. О. 
Published: October 2021

In the article, the author conducted a study of recurrence and recurrence as forms of multiplicity of premeditated murder under aggravating circumstances. The relevance of this work is that this issue has not been the subject of a separate study among modern scholars of criminal law. In the work the author found that the recurrence of premeditated murder under aggravating circumstances, it is necessary to distinguish from a criminal offense under paragraph 13 of Part 2 of Article. 115 of the Criminal Code of Ukraine (premeditated murder committed by a person who previously committed premeditated murder, except for murder under Articles 116-118 of the Criminal Code of Ukraine), which is considered a qualifying (aggravating sign) premeditated murder. After all, in the case of premeditated murder by a person who has previously committed premeditated murder, with the exception of murder provided for in Articles 116-118 of the Criminal Code of Ukraine, a single crime is necessarily meant. The author also emphasizes that the recurrence of premeditated murder under aggravating circumstances is available only if the person has previously been convicted of premeditated murder, but the conviction has not yet been removed and not expunged. Or when a person has committed premeditated murder under aggravating circumstances provided by the same part of the article of the Special Part of the Criminal Code of Ukraine two or more times, and all episodes are considered in one criminal proceeding. In addition, the paper found that recurrence and recidivism, as forms of multiplicity of premeditated murders under aggravating circumstances, are not mutually exclusive and can be used by the court as a whole. It is concluded that in judicial practice there are many cases when courts do not clarify the issue of expungement or removal of a criminal record when imposing a penalty for repeated intentional homicides in aggravating circumstances. Therefore, the solution of this issue, in our opinion, needs legislative consolidation. After all, the recurrence of premeditated murder under aggravating circumstances is available only if the person has previously been convicted of premeditated murder, but the conviction has not yet been removed and not expunged. Or when a person has committed premeditated murder under aggravating circumstances provided by the same part of the article of the Special Part of the Criminal Code of Ukraine two or more times, and all episodes are considered in one criminal proceeding.
ВЗАЄМОЗВ’ЯЗКИ І ФАКТОРИ ДОСЛІДЖЕННЯ СОЦІАЛЬНО-ПСИХОЛОГІЧНИХ ДЕТЕРМІНАНТ ОБРАННЯ МОЛОДДЮ ПРОФЕСІЇ ЕКОНОМІСТА
Authors: Мартиненко О. , Корольчук М. , Корольчук В. 
Published: October 2021

У статті представлено дослідження соціально-психологічних детермінант обрання молоддю професії економіста. На основі проведено системного аналізу отриманих даних, відповідно мети дослідження обстежуваних щодо обрання професії економіста за результатами емпіричного дослідження проведено кореляційний і факторний аналіз за 10 методиками з 71 показниками.
Визначено п’ять основних факторів соціально-психологічних детермінант обрання молоддю професії економіста: F1 – мотиваційний; F2 – професійно–інтелектуальний; F3 – адаптаційно-комунікативний; F4 – індивідуально-психологічний; F5 – темперементальний.
EFFECT OF WASTE GLASS POWDER ON THE SWELLING AND STRENGTH CHARACTERISTIC OF DISTRICT KARAK EXPANSIVE CLAY
Authors: Zamin Bakht , Nasir Hassan , Khan Beenish Jehan , Farooq Asim 
Published: October 2021

Expansive soils are generally considered problematic due to undesirable geotechnical characteristics like expansion, shrinking, settlement, and heaving. Such soils have low shear strength which decreases after wetting or other physical aggravations. Subsequently, such soils need proper improvement before constructing a structure on them. Different industrial wastes have been used for the stabilization of weak soil in the past. In the current investigation, the impact of waste glass powder (WGP) on the strength and swelling characteristic of swelling soils have been assessed. The primary target of this examination was to research the utilization of waste glass powder in geotechnical applications for controlling the settlement and expanding qualities. For this reason, the local expansive soil of district Karak, Pakistan was selected and their engineering properties were assessed. The experimental work consists of conducting the consistency limits, California bearing ratio (CBR), specific gravity standard Procter tests. The mentioned tests were carried out on both natural as well as modified specimens. For modification purposes, waste glass powder (WGP) was added in different proportions with the incremental rate of 4%, for instant 0%, 4%, 8%, 12%, 16%, and 20%. The addition of waste glass powder greatly reduced the swelling properties of the tested soil and also improved the engineering characteristics. A maximum reduction in swelling was observed at 20% addition of waste glass powder. Similarly, the liquid limid also reduced, and the specific gravity and maximum dry density increased at optimum glass powder content.
Pemanfaatan Layanan E-Banking oleh Nasabah Perbankan Syariah: Studi pada Bank Syariah Mandiri KCP Kepanjen
Authors: Saputra Prayogi Restia , Wahyuningtyas Tri 
Published: October 2021

Perbankan Syariah merupakan sistem perbankan yang sedang tumbuh di Indonesia. Maka, berbagai kajian tentang bank Syariah sangat dibutuhkan sebagai dukungan kajian akademik bagi perbankan syariah. Salah satu topik yang menarik adalah kebiasaan nasabah bank syariah dalam menggunakan fasilitas berbasis teknologi informasi atau yang disebut e-Banking. Penelitian ini bertujuan untuk mengkaji penggunaan fasilitas e-Banking oleh nasabah di Bank Syariah Mandiri KCP Kepanjen. Tujuan penelitian ini adalah untuk mengetahui pemanfaatan dari layanan e-Banking oleh nasabah Bank Syariah Mandiri KCP Kepanjen. Penelitian ini menggunakan metode kualitatif deskriptif. Sumber data primer didapatkan dari wawancara terukur terhadap 27 nasabah yang datang ke kantor bank. Penelitian ini menemukan bahwa layanan e-Banking kurang digunakan secara maksimal oleh nasabah. Penyebabnya adalah faktor usia, faktor intensitas penggunaan layanan perbankan, serta tempat tinggal nasabah.
Peranan Zakat, Infak dan Sedekah dalam Meningkatkan Kesejahteraan Ekonomi Masyarakat
Authors: Anjelina Eni Devi , Salsabila Rania , Fitriyanti Dwi Ayu 
Published: October 2021

Penulisan yang kami lakukan bertujuan untuk mengetahui peran yang telah dilakukan oleh zakat, infak dan sedekah dalam meningkatkan kesejahteraan sebuah perekonomian masyarakat yang ada di Indonesia, seperti judul jurnal yang telah kami berikan yakni berjudul “Peranan Zakat, Infak dan Sedekah dalam Meningkatkan Kesejahteraan Ekonomi Masyarakat” kemudian kami juga akan membahas tentang pengertian ZIS. Zakat, infak, dan sedekah ialah salah satu bentuk amal ibadah seorang muslim dengan tujuan untuk mencari rida dari Allah SWT. Dalam melakukan zakat, infak, dan sedekah dapat mengurangi jumlah kemiskinan yang ada. Maka dari itu perlu adanya badan pengelolaan yang mengurus zakat, infak, dan sedekah yang dapat mengelola dengan baik, dan dapat meningkatkan perekonomian masyarakat.
The partial waiver of the rights and partial invalidation of rights to the invention
Authors: Borovyk Petro 
Published: October 2021

Borovyk P. The partial waiver of the rights and partial invalidation of rights to the invention. In view of changes in the Law of Ukraine «About protection of rights for inventions and utility models» introduced according to the Law No. 816-IX as of 21.07.2020, it is implied that a patent owner can waive rights provided by a state registration of an invention (utility model) fully or partially, and a court can render the rights for the invention (utility model) invalid fully or partially. The partial waiver of the rights or rendering the rights invalid causes a number of issues on a rather frequent basis, in particular, regarding a certain procedure of defining the entire scope of rights according to the patent and a portion of these rights. Since the scope of rights is defined by claims, the partial waiver of the rights or the partial rendering the rights invalid substantially represents a change of the scope of rights, which are defined by the claims as published. The patent may be granted for a group of inventions. In such case, the scope of rights shall be defined by the claims that comprise several independent claims. Here, the partial waiver of the rights for the invention may be carried out by waiving one or several independent claims at the discretion of the patent owner or by rendering one or several independent claims invalid by the court. Therewith, the scope of rights that is defined during conduction of an examination for another invention of the group of inventions, which are mentioned in a single protection document (patent), is not changed. The partial waiver or the partial rendering the rights for the invention invalid for the claims having one independent claim is a more problematic case. A key aspect of this problem is an influence of the proposed amendments of the claims onto the scope of rights for the invention and its correspondence with the requirements for granting a legal protection. More specifically, it is an establishment of a fact of reduction of the scope of rights when introducing the proposed amendments into the independent claim and examination of a new version of the independent claim for compliance with the requirements of patentability. An important aspect also lies in establishment of a balance of interests of the patent owner and third parties. The patent owner will receive a mechanism of implementation of the right for protection of allowable embodiments of the invention, while the third parties will receive a right for a legal certainty by means of an analysis of the scope of rights of the new version of the claims. The article discloses grounds for waiving the rights for the invention and the mechanism for implementation of the waiver under the legislation in force both for the case of the group of inventions and for the partial waiver or the partial rendering the rights for the invention invalid with the claims having one independent claim.
Keywords: scope of rights, independent and dependent claims, amendment to claims, proceedings
Open innovation in terms of legal protection of intellectual property
Authors: Yarmoliuk Anastasiia 
Published: October 2021

Yarmoliuk A. Open innovation in terms of legal protection of intellectual property. The author notes that according to the latest global trends in the development of intellectual property rights, business entities operate in the context of radical changes taking place in most sectors of the economy. As new breakthrough technologies and subjects of innovative activity appear. The article emphasizes that this perspective envisages the transition of Ukraine to a new production system, which requires institutional changes. According to the author, today there is also a tendency to reduce the life cycle of innovations, increase the speed of implementation of new developments and strengthen the trends of digital transformation. Therefore, the digitalization of the economy requires the involvement of new forms of cooperation with open innovations including new business models for the use of intellectual property. The article notes that intellectual property, in turn, plays a key role in the development of innovation. At the same time, the importance of intellectual property within the model of open innovation changes with the transformation of economic processes into a creative economy. Today, there is an extremely low level of implementation of creative innovative developments, which indicates the ineffectiveness of the strategy for commercialization of research results. As the author emphasizes, the open innovation model is aimed at solving this problem. Exactly the exchange of knowledge and new results between innovative enterprises and their partners is a major lever for further creative innovation. Therefore, the author determines that effective legal protection of intellectual property plays a key role in promoting innovation within the concept of open innovation. Innovative technologies have been successfully commercialized with the strategic use of intellectual property rights. As indicated in the article, intellectual property also significantly enhances the competitiveness of innovative enterprises, preserves their innovative advantages, and facilitates the process of bringing innovative technologies created under the open innovation model to the market.Keywords: open innovation, intellectual property rights, intellectual property, innovative enterprise, «smart city»
Relative Efficacy of Dry-Off Antimicrobial Treatments in Dairy Cattle to Cure Existing Intramammary Infections: A Systematic Review and Network Meta-Analysis
Authors: McMullen Carrie K. , Sargeant Jan M. , Kelton David F. , O'Connor Annette M. , Reedman Cassandra N. , Hu Dapeng , Glanville Julie , Wood Hannah , Winder Charlotte B. 
Published: October 2021

This systematic review and network meta-analysis aimed to estimate the relative efficacy of dry cow antimicrobial therapies, registered in Canada and/or the United States, to cure existing intramammary infections (IMI) in dairy cattle. The controlled trials examining all-cause cures of existing IMI present at dry-off were eligible. Five databases and four conference proceeding platforms were searched. The risk of bias at the level of the outcome was assessed using the Cochrane 2.0 risk of bias instrument (Cochrane, Denmark), and the overall confidence in the findings from the network meta-analysis was assessed using the Confidence in Network Meta-Analysis (CINeMA) platform. Of 3,743 articles screened for eligibility by the two independent reviewers, 58 trials were included in the Bayesian network meta-analysis for the all-cause cure of existing IMI from dry-off to calving. No antimicrobial treatment (non-active control) was associated with a decreased risk of a cure compared with all other currently labeled antimicrobials in Canada and the United States; however, lack of replication trials for some antimicrobial products created large credibility intervals and, therefore, we were unable to identify meaningful comparisons between the products. Poor reporting of trial features, heterogeneity in outcome measurements, and high risk of bias in some domains further contributed to this inability to compare antimicrobials. Continued improvement in the reporting of animal trials is required to make recommendations for antimicrobial products on the basis of efficacy.Systematic Review Registration:https://atrium.lib.uoguelph.ca/xmlui/bitstream/handle/10214/16236/Protocol_NMA_efficacy_dryoff_antibiotics_cure_IMI.pdf?sequence=3&amp;isAllowed=y.
Protection and Controlled Gastrointestinal Release of Bromelain by Encapsulating in Pectin–Resistant Starch Based Hydrogel Beads
Authors: Mala Thatchajaree , Anal Anil Kumar 
Published: October 2021

Hybrid pectin and resistant starch–based hydrogel beads loaded with bromelain using the extrusion gelation method were prepared and evaluated to enhance the activity of bromelain during gastrointestinal passage and thermal processing. The solutions of pectin–resistant starch with bromelain were dropped into the gelation bath containing calcium chloride (0.2 M) solution to develop various types of hydrogel beads. The physicochemical characteristics of the synthesized hydrogel beads were evaluated. The ratio (4.5:1.5 w/w) of pectin and resistant starch concentration significantly (p &lt; 0.05) enhanced the encapsulation efficiency (80.53%). The presence of resistant starch resulted in increased entrapment of bromelain, improved swelling properties with sustained release behavior, and improved gastric stability than pectin hydrogels alone. The swelling of hydrogel beads was higher at pH 7.4 than pH 1.2. Optimized batch of hybrid pectin/resistant starch exhibited a spherical shape. Optical and scanning electron microscopy showed a more packed and spherical shape from the pectin/resistant starch hydrogel bead network. Fourier transformation infrared spectroscopy was also used to confirm the presence of bromelain in the hydrogel beads. The encapsulated bromelain in the pectin/hi-maize starch beads produced at a pectin/hi-maize ratio of 4.5:1.5 (percent w/w; formulation P4) obtained the highest relative bromelain activity in all heat treatments including at 95°C, whereas the highest activity of free bromelain was found only at 30°C. Bromelain encapsulated in hydrogels released at a faster rate at simulated intestinal fluid (SIF, pH 7.4) than at simulated gastrointestinal fluid (SGF, pH 1.2).
Efficacy and Safety of Drug-Eluting Bead Bronchial Arterial Chemoembolization Plus Anlotinib in Patients With Advanced Non-small-Cell Lung Cancer
Authors: Liu Juanfang , Zhang Wenguang , Ren Jianzhuang , Li Zhen , Lu Huibin , Sun Zhanguo , Han Xinwei 
Published: October 2021

Aim: The aim of this study is to determine the efficacy and safety of the combination therapy of drug-eluting bead bronchial arterial chemoembolization plus anlotinib oral administration in the treatment of non-small-cell lung cancer (NSCLC).Methods: Consecutive data from 51 patients with advanced NSCLC were retrospectively collected from February 2018 to August 2019. All patients underwent drug-eluting bead bronchial arterial chemoembolization (DEB-BACE) followed by anlotinib treatment. Overall survival (OS) and progression-free survival (PFS) were calculated and analyzed using the Kaplan–Meier method and log-rank test, and factors associated with OS and PFS were assessed by a Cox proportional hazards test. Treatment response at 30 days was assessed by enhanced computed tomography (CT), and then the objective response rate (ORR) and disease control rate (DCR) were calculated. Treatment-related adverse events (TRAEs) were also evaluated.Results: The median OS was 18.4 months (95% CI, 16.6–20.2 months), and the median PFS was 8.4 months (95% CI, 6.2–10.6 months). The ORR and DCR for the whole cohort were 21.6 and 100%, respectively, at 30 days after the first cycle of treatment. Most of the treatment-related adverse reactions were mild and moderate and included anorexia, hypertension, fatigue, and hand-foot syndrome. Only eight (15.7%) patients developed grade 3 TRAEs. No deaths or other serious adverse reactions occurred. Both TNM stage and brain metastasis were independent risk factors for OS and PFS.Conclusion: DEB-BACE concomitant with anlotinib has promising efficacy and tolerable toxicity in patients with advanced NSCLC.
Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction
Authors: Sun Yuxi , Si Jinping , Li Jiaxin , Dai Mengyuan , King Emma , Zhang Xinxin , Zhang Yanli , Xia Yunlong , Tse Gary , Liu Ying 
Published: October 2021

Aims: HFA-PEFF score has been proposed for diagnosing heart failure with preserved ejection fraction (HFpEF). Currently, there are only a limited number of tools for predicting the prognosis. In this study, we evaluated whether the HFA-PEFF score can predict mortality in patients with HFpEF.Methods: This single-center, retrospective observational study enrolled patients diagnosed with HFpEF at the First Affiliated Hospital of Dalian Medical University between January 1, 2015, and April 30, 2018. The subjects were divided according to their HFA-PEFF score into low (0–2 points), intermediate (3–4 points), and high (5–6 points) score groups. The primary outcome was all-cause mortality.Results: A total of 358 patients (mean age: 70.21 ± 8.64 years, 58.1% female) were included. Of these, 63 (17.6%), 156 (43.6%), and 139 (38.8%) were classified into the low, intermediate, and high score groups, respectively. Over a mean follow-up of 26.9 months, 46 patients (12.8%) died. The percentage of patients who died in the low, intermediate, and high score groups were 1 (1.6%), 18 (11.5%), and 27 (19.4%), respectively. A multivariate Cox regression identified HFA-PEFF score as an independent predictor of all-cause mortality [hazard ratio (HR):1.314, 95% CI: 1.013–1.705, P = 0.039]. A Cox analysis demonstrated a significantly higher rate of mortality in the intermediate (HR: 4.912, 95% CI 1.154–20.907, P = 0.031) and high score groups (HR: 5.291, 95% CI: 1.239–22.593, P = 0.024) than the low score group. A receiver operating characteristic (ROC) analysis indicated that the HFA-PEFF score can effectively predict all-cause mortality after adjusting for age and New York Heart Association (NYHA) class [area under the curve (AUC) 0.726, 95% CI 0.651–0.800, P = 0.000]. With an HFA-PEFF score cut-off value of 3.5, the sensitivity and specificity were 78.3 and 54.8%, respectively. The AUC on ROC analysis for the biomarker component of the score was similar to that of the total score.Conclusions: The HFA-PEFF score can be used both to diagnose HFpEF and predict the prognosis. The higher scores are associated with higher all-cause mortality.
Clinical Profile and Prognosis of a Real-World Cohort of Patients With Moderate or Severe Cancer Therapy-Induced Cardiac Dysfunction
Authors: Esteban-Fernández Alberto , Carvajal Estupiñan Juan Fernando , Gavira-Gómez Juan José , Pernas Sonia , Moliner Pedro , Garay Alberto , Sánchez-González Álvaro , Fernández-Rozas Inmaculada , González-Costello José 
Published: October 2021

Introduction and Objectives: Cancer therapy-related cardiac dysfunction (CTRCD) is a common cause of cancer treatment withdrawal, related to the poor outcomes. The cardiac-specific treatment could recover the left ventricular ejection fraction (LVEF). We analyzed the clinical profile and prognosis of patients with CTRCD in a real-world scenario.Methods: A retrospective study that include all the cancer patients diagnosed with CTRCD, defined as LVEF &lt; 50%. We analyzed the cardiac and oncologic treatments, the predictors of mortality and LVEF recovery, hospital admission, and the causes of mortality (cardiovascular (CV), non-CV, and cancer-related).Results: We included 113 patients (82.3% women, age 49.2 ± 12.1 years). Breast cancer (72.6%) and anthracyclines (72.6%) were the most frequent cancer and treatment. Meantime to CTRCD was 8 months, with mean LVEF of 39.4 ± 9.2%. At diagnosis, 27.4% of the patients were asymptomatic. Cardiac-specific treatment was started in 66.4% of patients, with LVEF recovery-rate of 54.8%. Higher LVEF at the time of CTRCD, shorter time from cancer treatment to diagnosis of CTRCD, and younger age were the predictors of LVEF recovery. The hospitalization rate was 20.4% (8.8% linked to heart failure). Treatment with trastuzumab and lower LVEF at diagnosis of CTRCD were the predictors of mortality. Thirty point nine percent of patients died during the 26 months follow-up. The non-CV causes and cancer-related were more frequent than CV ones.Conclusions: Cardiac-specific treatment achieves LVEF recovery in more than half of the patients. LVEF at the diagnosis of CTRCD, age, and time from the cancer treatment initiation to CTRCD were the predictors of LVEF recovery. The CV-related deaths were less frequent than the non-CV ones. Trastuzumab treatment and LVEF at the time of CTRCD were the predictors of mortality.