bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of platelet functionality in pediatric patients with kaposiform hemangioendothelioma / Kasabach-Merritt phenomenon
Authors: Martyanov Alexey , Tesakov Ivan , An Olga , Korobkin Julia-Jessica , Ignatova Anastasia , Svidelskaya Galina , Yushkova Eugenia , Koltsova Ekaterina , Podoplelova Nadezhda , Novichkova Galina , Khachatryan Lili , Eble Johannes , Kalinin Dmitrii , Sveshnikova Anastasia 
Published: December 2021

Background. Kaposiform hemangioendothelioma (KHE) is a rare
vascular tumor of infancy commonly associated with Kasabach-Merritt
phenomenon (KMP) that includes thrombocytopenia and coagulation
dysfunction. Platelet receptor CLEC-2 -tumor cell podoplanin interaction
is considered the key mechanism of thrombocytopenia in KMP, however, the
effect of long-term exposure to podoplanin on platelet function is
unknown.
Procedure. Here we examined blood samples from 7 patients with
KHE/KMP. Platelet calcium signaling and functional responses to
conventional activation and CLEC-2 stimulation were analyzed by
continuous and endpoint live cell flow cytometry. Platelet aggregation
in response to ADP or rhodocytin was analyzed by low-angle light
scattering approach (LaSca). Additionally, ex vivo thrombus formation on
collagen was observed in parallel-plate flow chambers.
Results. We demonstrate that in KHE/KMP platelet functional
responses to strong stimulation were on the lower boundary of
age-matched normal ranges, while calcium mobilization and fibrinogen
binding upon stimulation with ADP alone were significantly lower than
control values. Platelet di-aggregate formation in response to ADP was
also diminished in most of the patients. Formation of platelet
aggregates in collagen-coated parallel plate flow chambers was also
noticeably lower than in the age-matched control group. Calcium
mobilization in response to CLEC-2 stimulation was unaltered in the
patients and could be blocked by low-molecular-weight inhibitors, 2CP
and HB125.
Conclusions. While platelet responsiveness in KHE/KMP is
moderately altered, platelet CLEC-2 receptors remain functional and
respond to inhibition. Therefore, our findings suggest that
CLEC-2-targeting molecules are new potential agents in therapeutic
management of this life-threatening condition.
The Value of Auditor Industry Specialization: Evidence from a Structural Model
Authors: Guo Qiang , Koch Christopher , Zhu Aiyong 
Published: December 2021

ABSTRACT
This study investigates the value of auditor industry specialization. In the first step, we use a discrete choice model to derive the first-order demand for auditor industry specialization. Our results reveal that clients have a general preference for auditor industry specialization, relating to both audit firm and audit office specialization. We observe that specializations at the audit firm and audit office level are substitutes. We also find that larger, more complex clients have a stronger demand for industry specialization at the audit office level. In the second step, we use the results from the discrete choice model to quantify the value of auditor industry specialists for clients. We find the overall value of industry specialization aggregated across all clients is 5.2 million USD (0.36 percent of audit fees) and that industry specialization at the firm (office) level is decisive for auditor choice in 4 percent (6 percent) of all cases.
JEL Classifications: M42; M48; L11; L84.
Analysis of Using Google Voice as Learning Media through Task-Based Learning Method
Authors: Muzdalifah Indah 
Published: December 2021

There are many choices of media based on Technology can be used in teaching English. One of them is Google voice, it can be found in any types of smart phone. This media can help students in recognizing the better pronunciation. Thus, it can revise their listening comprehension in English. This research is aimed to describe the role of Google voice in listening comprehension course as well as improve their listening comprehension. The method of this research is qualitative research where the data was obtained by getting the information from online questionnaire and the test. The result of this research from 43 students it was found that 91, 62% agree that the Google Voice application as the Learning English medium. Meanwhile, the result of the test after using Google voice is increasing from 68, 2% to 73, and 54%. It can be concluded that the use of Google voice gives positive effect in learning English.
Cross Sectional Study on The Association of Daily Spiritual Experience on Mental Well Being During COVID 19 Among The African Students In India
Authors: Joseph Sheeba 
Published: December 2021

Objectives: The current research focussed to explore the association of daily spiritual experience on the mental well- being of international students hails from Africa and pursuing studies in various higher education institutions in India. The research also tried to explore whether age and gender plays a significant role in the mental well- being of the respondents.
Design: The study is an exploratory cross-sectional in nature. The research tool comprised of the Daily Spiritual Experience Scale (DSES) and Warwick-Edinburgh Mental Well-being Scale (WEMWBS) along with the demographic details. Post reliability and validity tests, established scales are used to study the variable in the research. The data was analysed using Smart PLS SEM 3.3.2.
Setting: The respondents comprise of international students hails from Africa and pursuing various under graduate, post graduate and PhD courses from various institutions at Bhopal, Delhi, Mumbai and Rajasthan in India. The respondents include a cohort of 102 respondents who gave consent to be part of the study during first week of July to first week of August 2021 and were selected through purposive sampling technique.
Main outcome measures: The research measures the association of daily spiritual experience and mental well-being during pandemic and also the coping strategies used by the respondents.
Findings: The research report shows an insignificant relation of gender to the mental well-being whereas age reported a significant association. A significant association is reported between daily spiritual experience and the mental wellbeing of the respondents amidst pandemic situation.
Conclusion: Pandemic outbreaks influences the mental well-being of individuals specially when they are away from the social support system. Hence counselling services and other interventions to cater to the needs of students requires a serious deliberation at the policy level.
Garaño, Santiago (2020). Memorias de la prisión política durante el terrorismo de Estado en la Argentina (1974-1983).
Authors: Pighin Daniela 
Published: December 2021

En 2020 se publicó Memorias de la prisión política durante el terrorismo de Estado en la Argentina (1974-1983), investigación del antropólogo Santiago Garaño que forma parte de la colección de acceso abierto “Entre los libros de la buena memoria”, impulsada por las Universidades Nacionales de La Plata, Misiones y General Sarmiento. Se trata de un trabajo que aborda una problemática con poca visibilidad dentro de los estudios sobre violencia política: la experiencia de militancia y represión vivida por detenidas y detenidos por razones políticas entre 1974 y 1983.
The antioxidant effects of melatonin in blood platelets during exposure to electromagnetic radiation – an in vitro study
Authors: Lewicka Małgorzata , Zawadzka Magdalena , Henrykowska Gabriela , Rutkowski Maciej , Buczyński Andrzej 
Published: December 2021

Abstract

Objectives
The article presents the results of an in vitro study aimed at identifying changes in parameters of oxidative stress – concentration of malondialdehyde (MDA), enzymatic activity of superoxide dismutase (SOD-1) and protective antioxidant role of melatonin (MLT) during the exposure of blood platelets to electromagnetic radiation (EMR) emitted by monitors.

Methods
Platelets were exposed to an EMR for 30- and 60 min. generated by monitors (1 kHz frequency, 220 V/m intensity). In each sample the level of SOD-1 activity and concentration of MDA were determined.

Results
The MDA concentration increased significantly after 30-and 60-min. irradiation, as compared to control values (2.53 vs 1.36; 3.64 vs 1.36 nmol/109 blood platelets) and after the addition of MLT it decreased (2.53 vs 1.55; 3.64 vs 1.12 nmol/109 blood platelets). The activity of SOD-1 increased significantly compared to control values after 30 min. and 60 min. of exposure to EMR (1.97vs 0.75; 2.08 vs 0.75 U/g of protein), and significantly decreased after the addition of MLT only in samples exposed for 60 min. (2.08 vs 0.95 U/g of protein).

Discussion
The results demonstrated the possibly negative effect of EMR on oxygen metabolism of blood platelets and indicated a possible protective role of melatonin in this process.
Statistical Analysis of Interdependence of ICT and Economic Development of Selected European Countries
Authors: Stamenković Milan , Milanović Marina , Petrović Dragana Rejman 
Published: December 2021

Abstract
The research focus on the analysis of interdependence of economic and ICT development results from the fact that, in recent decades, ICTs have become a dominant factor in generating socio-economic prosperity of countries. ICT expansion is a stimulus for economic growth, and vice versa. In order to empirically verify the observed interdependence, on the example of the selected 37 European countries, a two-stage statistical analysis was conducted, based on a combined application of cluster analysis and a oneway analysis of variance. Using specific data from 2017, the following was conducted: (a) formation of groups of countries by implementing cluster analysis based on the three structural components of the ICT Development Index; and (b) by applying the ANOVA method and using the values of GDP per capita, testing the validity of assumption regarding the existence of statistically significant differences, in terms of the achieved level of economic development between the formed groups of countries of different levels of ICT development. The obtained results suggest the extraction of three clusters of countries and the acceptance of the defined hypothesis. Serbia is classified within the cluster of medium ICT development level and is characterized by the value of GDP per capita that is significantly below the group average, which indicates the possibility and the need for improvement in the ICT field.
Production and Circulation of Technical Knowledge on Building Sites at the End of the Eighteenth Century
Authors: Nègre Valérie 
Published: December 2021

Abstract
This article aims to shed light on the exchange of technical knowledge between architects, master craftsmen and workmen on building sites at the end of the eighteenth century. In the Age of Enlightenment, major building sites were places where a large number of skilled practitioners of various ranks met (engineers, architects, contractors, experts, craftsmen). These were therefore places where the exchange of knowledge and know-how occurred but also places of struggle for power and knowledge. The article examines these exchanges and struggles using the case study of the building site for the dome of the Halle au Blé in Paris (1782-1783).
Making Modern Knowledge of Traditional Carpentry in China and Japan: Myth, Reality and Transmission
Authors: Congcong Ren 
Published: December 2021

Abstract
Carpentry skills were among the most important elements of building practice in premodern China and Japan, and traditional carpentry skills continue in use in both countries to the present day. Although their importance has been greatly marginalised in building practice, in both countries some master carpenters have gained public recognition. This paper compares the modernisation of traditional building knowledge in China and Japan, and the fate of carpentry knowledge as the building industry and the formal discipline of architecture evolved. It distinguishes three phases in this historical trajectory: the period during the introduction of Western architecture as a discipline, when traditional knowledge was rejected or used selectively in the construction of national histories of building; the period when modern technology took over the main building industry and traditional craftsmen had to confront the realities of new technologies of production; and the period, still unfolding today, where heritage movements are promoting the recuperation and development of traditional craft knowledge. For each country, the paper traces how the nation’s history of building was selectively fashioned into an orthodox narrative; explores the content of key early technical works (for China, the official handbook Yingzao fashi [Building standards] and the craftsman’s manual Lu Ban jing [Carpenters’ Canon], and for Japan kikujutsu [literally, “compass and ruler techniques”] books); and shows how a talented master carpenter succeeded in creating a niche for himself within the contemporary heritage culture. It concludes that differences in the cultural respect accorded to carpentry knowledge in the two countries are rooted in the contrasting status of craftsmen in the premodern era.
Distant learning as a way to meet challenges: teaching English for medical students
Authors: Pechinkina Olga , Vepreva Tatiana 
Published: December 2021

Abstract
In 2020 the world encountered a new virus. Nobody could predict it but it happened. The boundaries between countries were closed, people were obliged to stay at home, schools and universities were shut and the education was transferred online. We have to admit that not all educational institutions were ready to switch to the online format of teaching in such a short period. However, in conditions when there are no possibilities for face-to-face teaching educators are forced to find the most efficient ways of teaching English. In this paper, the authors aim to investigate online resources able to compensate for the lack of face-to-face communication. While doing research critical analysis of existing literature and generalisation of teaching experience were used. The findings revealed that even in distant learning particular resources can recompense for the absence of offline learning.
Monitored therapy of sporadic mycobacteriosis caused by Mycobacterium genavense in Atlantic canaries (Serinus canaria) and Bengalese finch (Lonchura striata)
Authors: Ledwoń Aleksandra , Dolka Izabella , Adamczyk Krzysztof , Szeleszczuk Piotr 
Published: December 2021

Abstract

Introduction
Mycobacteriosis is a significant disease of companion and wild birds which causes emaciation and widely distributed lesions, as well as being a potential zoonosis. Its primary aetiological agents in birds are Mycobacterium avium subsp. avium and the fastidious Mycobacterium genavense. This study monitored the therapy of birds naturally infected with Mycobacterium genavense to gain understanding of its effectiveness and the interrelation of co-infections with the disease course and pharmacotherapy.

Material and Methods
Five Atlantic canaries (Serinus canaria) and one Bengalese finch (Lonchura striata) with tentative diagnoses of mycobacteriosis resulting from M. genavense infection were treated twice daily with clarithromycin at 40 mg/kg, ethambutol at 30 mg/kg, and moxifloxacin at 10 mg/kg for 6 months. Two canaries were also found to be carriers of Cryptosporidium galli. Mycobacteria in faecal samples of all birds were investigated by bacterioscopy and quantitative PCR.

Results
Molecular tests yielded positive results for up to four months after treatment initiation for M. genavense and Cryptosporidium, but microscopy failed to detect the latter after four weeks in specimens from one canary. Co-infections with polyomavirus (in all birds) and circovirus and bornavirus (in canaries) were diagnosed. Two birds died during treatment and one was euthanised because of other disease, 1 month after treatment completion. Three canaries were in relatively good health a year after treatment.

Conclusion
Canary circovirus and polyomavirus co-infection may suppress the immune system and this may facilitate the development of mycobacteriosis. The set of drugs used led to the complete cure of mycobacteriosis in three canaries. In one bird the disease returned. Clarithromycin was the active drug against C. galli. Molecular methods serve well to monitor mycobacteriosis therapy and identify M. genavense and C. galli carriage.
Implementation of a Pull System – A Case Study of a Polymeric Production System for the Automotive Industry
Authors: Martins Bruna , Silva Cláudia , Silva Diogo , Machado Laura , Brás Miguel , Oliveira Rui , Carvalho Tiago , Silva Vera , Lima Rui M. 
Published: December 2021

Abstract
This work, developed as a case study, propose, describe, and evaluates an implementation of a pull system in a SME company producing polymeric components for the automotive industry. The production system of the company was based on the push paradigm, which creates high stock levels and high lead times. The main purpose was to develop a pull production system controlled by Kanbans in the painting line. To achieve this goal, this case study demonstrates the application of relevant lean tools, such as, VSM, SMED, Kanban System, Supermarkets and Leveling. Through the SMED’s application, it was possible to reduce the setup times in 38% and make annual earnings of approximately 83000€. The application of a Kanban System, Leveling and Supermarket enabled the WIP’s reduction between injection and painting in 56% and, also, between painting and expedition in 45%. Also, the lead time decreased and the value-added time increased. Thus, this is an exemplary case study for the implementation of a pull system and can be used both by practitioners and researchers interested in this theme.
Cluster Analysis of Existing Technoparks in Developed Countries
Authors: Shaidurova Natalia , Prajova Vanessa , Smirnov Vitaliy , Livenskaya Galina 
Published: December 2021

AbstractThis article provides a cluster analysis of existing technoparks, the sample of which was built according to the completeness of the data presented on the official websites of the Ministry of Industry and Trade of the Russian Federation and the terms of operation. The analysis is carried out in order to determine the best components of the effectiveness of the development of the technopark movement in Russia. According to the analysis of this article, we can talk about a weak relationship between the three sub-indices: the activities of the management company, the activities of residents, the activities of regional authorities. The obtained data can serve as a starting base for further construction of an econometric model of the efficiency factors of technoparks.
Esboço De Uma Interpretação Fenomenológica Da Imaginação Material De Bachelard
Authors: Araújo Joaquim Carlos 
Published: December 2021

Abstract
La grille phénoménologique ordinairement, et la phénoménologie husserlienne en particulier, sont les outillages conceptuels que d’un mode général peuvent éclairer la magnifique prose bachelardienne, nommément sa pensée esthétique sur l’ imagination des matières, sur la rêverie matérielle de la tétralogie des élements naturels. De même que le phénomène n’est pas au-delà de son apparaître, aussi l’ image matérielle, elle même, s’épuise dans cet acte d’une évidence aprioristique, ce qui lui confère le sens propre de l’image, à savoir, l’image par l’ image. L’imagination se constitue donc en tant qu’une unité de présentafication / neutralisation au dedans de la consciense esthétique. Nous pouvons distinguer la fonction thématique de l’imagination de la fonction positionelle de l’imagination et les rapporter au lieu originel d’une irrealité, d’un fictum.
Paul Ricœur’s Hermeneutics Towards Reflexive Philosophy
Authors: Ribeiro João Amaral 
Published: December 2021

Abstract
Essential philosophical question according to Paul Ricœur: the ontological and epistemological possibility of the understanding of the self.
Philosophy as reflection, ethics and herrneneutics; reflection taken as a task of position, interpretation and appropriation of the self; ethics as the effort of emancipation is required; hermeneutics as ontic-existential investigation which deals with the situation of sharing belonging (pre-understanding) and the critical distanciation which come with or judge rival or opposing interpretations; understanding of the self as a consequence an a unfinished interpretation of the envolving significant signs (symbols and texts); interpretation as dialectic relation between understanding (synthesis, truthful guess and appropriation as far as reference is concemed) and explanation (analysis, clarification and methodological validation as far as sense is concemed) in the dynamic process of reading.
Ricœur’s perspective – framed in reflexive philosophy and as a hermeneutic variation of Husserl’s phenomenology starting from the epistemology to the ontology of the understanding.
Heidegger e as Ciências
Authors: Melim Nuno 
Published: December 2021

Abstract
In this paper we deal with a not so slight misunderstanding about Heidegger’s conception of science(s). We try to show that instead of a so-called «anti-scientism» we find rather a critical thought on the part of Heidegger. Critical in two senses: one that implies a questioning and an explicitation of the pre-scientific, non-scientific foundations (or conditions) of science and the analysis of the relation between sciences as «regional ontologies» and philosophy as «fundamental ontology»; another that suggests the «need of another thinking», an alternative (certainly discussible) to the predominant calculative thinking of «the era of science».
Market Analysis and Meal Ready-to-Eat Main Course Development in the Context of Military Use
Authors: Raits Ēvalds , Ķirse-Ozoliņa Asnate , Muižniece-Brasava Sandra 
Published: December 2021

Abstract
A one-day ration can be supplied to a soldier in the form of one ration pack for 24 hours or three packs of meal ready-to-eat, which equals one 24-hour ration. Based on the physical activity level and consequently energy requirements, there are two categories of military operations: a) normal operations, comparable to urban police work or firefighting, and b) combat operations which represent missions involving light-infantry. The aim of this study was: a) to analyse the EU market on the subject of a main course (MC) product in flexible packaging (n = 184), in the context of military use, and b) to develop thermostabilised MC aligning with modern health and nutrition recommendations for military use, i.e. protein, carbohydrate, fat, total energy intake, and essential amino acid composition. The greatest amount of ready-to-eat meals with shelf-life over one year are produced in the United Kingdom (n = 48) and most of the MC meals are preserved using freeze-drying (n = 135). While 90% of analysed products meet fat criteria for a physically active consumer (i.e. soldier), 39% meet carbohydrate criteria, 21% meet energy intake criteria, only 1% of the products are able to fulfill protein requirements. In this study, nine MC meals with shelf-life of three years were developed, which provide the necessary protein amount for a highly physically active consumer and cover its daily essential amino acid requirements.