bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior-stabilized Arthroplasty Versus Cruciate-retaining Arthroplasty in Treatment of Osteoarthritis: a 5-year Follow-up Study
Authors: Niu Yingzhen , Bai Weixia , Ji Gang , Kang Huijun , Piao Kang , Dong Zhenyue , Dong Conglei , Wang Fei 
Published: May 2021

Abstract
Backgroud: A prospective cohort study was performed to compare clinical outcomes between cruciate-retaining (CR) and posterior-stabilized (PS) arthroplasty.Methods: In total, 210 patients (210 knees) underwent CR arthroplasty (n=102) and PS arthroplasty (n=108) from January 2014 to January 2015. The Knee Society Score (KSS), range of motion, patellar stability, and complications were compared between the CR and PS groups 5 years postoperatively. Results: The CR group comprised 99 knees and the PS group comprised 105 knees at the 5-year follow-up. In the CR and PS groups, the mean postoperative KSS improved to 90±5 and 91±4, and the function score improved to 87±4 and 84±6, respectively (p>0.05). The mean postoperative range of motion was −2°±3° extension to 114°±8° flexion in the CR group and −2°±4° extension to 126°±7° flexion in the PS group, with no significant difference (p>0.05). In terms of patellofemoral complications, eight patients had patellar clunk syndrome, one had patellar subluxation, and one had patellar lateral facet fracture in the PS group. Three patients had patellar clunk syndrome, and one had symptomatic subluxation in the CR group. These patellofemoral complications were significantly different between the groups (p<0.05).Conclusions: CR and PS TKA can achieve good clinical outcomes with respect to the KSS. Better knee flexion but more patella complications in the PS arthroplasty than CR group 5 years postoperatively.Trail registration: This study was approved by our hospital institutional ethics committee.
Psoriasis Is Associated With Worse Quality of Life Compared With the Other 12 Skin Diseases: A Cross-sectional Study
Authors: Zhou Li , Ouyang Wenwei , Wen Zehuai , Lu Chuanjian , He Zehui 
Published: May 2021

Abstract
Background: Skin diseases impair patients’ quality of life (QoL). Psoriasis is of particular concern because it affects multiple facets of patients’ lives.Objective: The aim of this study was to investigate whether having psoriasis was associated with the more severe QoL impairment compared with the other 12 skin diseases, based on the Dermatology Life Quality Index (DLQI).Methods: This multicenter observational cross-sectional study was conducted in 9centers in China. Socio-demographic variables and health history were collected with a standardized form questionnaire. QoL was measured by the DLQI. DLQI scores were compared between patients with psoriasis and without psoriasis using univariate analysis. Then multivariate linear regression was used to related QoL to groups (psoriasis vs. non psoriasis), clinical and socio-demographic characteristics.Results: Of 8,339 included dermatological participants, 1,310 (15.7%) had psoriasis, and 7,029 (84.3%) did not. The QoL of patients with psoriasis was lower than that of patients without psoriasis based on the DLQI score (11.20 ± 7.37 vs 8.12 ± 6.26, P < 0.05). The results of multivariate linear regression indicated the same results when adjusting clinical and socio-demographic characteristics.Conclusion: Patients with psoriasis experience more quality of life impairment than patients without psoriasis. More attention should be paid to patients with psoriasis in dermatological health policy decision.
Stigmatization and Psychological Impact of COVID-19 Pandemic on Frontline Healthcare Workers in Nigeria: A Qualitative Study
Authors: Kwaghe Ayi Vandi , Kwaghe Vivian Gga , Habib Zaiyad Garba , Kwaghe Gga Vandi , Ilesanmi Olayinka Stephen , Ekele Bissalah , Umeokonkwo Chukwuma David , Balogun Muhammad Shakir 
Published: May 2021

Abstract
Introduction: The COVID-19 pandemic has had a great toll on global health. Frontline healthcare workers (FHCW) directly involved in the treatment of COVID-19 patients have faced some physical and psychological challenges. This study explored the stigma and traumatic experiences of the FHCW during the COVID-19 pandemic in Nigeria. Methods: We recruited twenty FHCW directly involved in the treatment of COVID-19 patients through purposive and snowball sampling techniques. Face-to-face in-depth interviews were conducted for all participants, and qualitative analysis of data was done using Colaizzi's phenomenological method.Results: Five themes identified were: Early stage of the pandemic (fear, anxiety, public fright and countries repatriating their citizens, the socio-economic impact of the pandemic and a call to duty for the FHCW); working with COVID-19 patients (excitement on patients recovery and duty stress); psychological, mental and emotional trauma; stigmatization (stigmatized by colleagues, family, friends or their residential communities, reasons for stigmatization which were fear of infection, limited knowledge of the virus and working at the isolation centre and the effect of stigma); and recommendations (education and awareness creation, government showing more care towards the FHCW and provision of health insurance for FHCW to take care of those that get infected in the line of duty).Conclusion: Stigmatization has proven to be a major challenge for FHCW in conducting their duties. The psychological impact experienced by FHCW may affect the quality of the services rendered by these workers. The study reveals the need of education and awareness creation in the ongoing pandemic. There is a need for the government and society to acknowledge and appreciate the efforts of FHCW.
Weighted Gene Co-Expression Network Analysis Reveals a New Survival Model for Prognostic Prediction in Ewing Sarcoma
Authors: Li Debao , Wang Lei , Wang Guanghui , Yang Yaowen , Yang Weiyu , Wang Hurong , Ma Yingui , Zhang Jin , Tian Jianing , Jia She , Cong Yujie , Li Jing , Xia Liang 
Published: May 2021

Abstract
Background: Ewing sarcoma (ES) is a malignant bone or soft-tissue cancer that mainly arises in children and young adults. However, the prognosis of Ewing sarcoma remains very poor, and there is no effective prediction method. The aim of our study was to identify a prognostic model for ES patients based on prognosis-associated mRNA expression profiles. Methods: The GSE17679 dataset was downloaded from the Gene Expression Omnibus (GEO) database. Differently expressed genes (DEGs) between ES and normal control were identified using R package “limma”. A weighted gene co-expression network analysis (WGCNA) was used to screen gene modules associated with recurrence/metastasis and survival status based on DEGs. Results: The prognostic model was constructed based on genes in MEbrown module, which was most associated with recurrence/metastasis and survival status, using Kaplan-Meier survival and lasso regression analysis. Sixteen genes were screened to construct the prognostic model. ES patients were grouped into high- and low-risk groups based on the median of risk score calculated for each of them. ES patients in high-risk group have worse survival than patients in low-risk group. The AUCs (Area under the ROC curve) for 1-year, 3-year, and 6-year overall survival were 0.903, 0.995, 0.953. Conclusions: Taken together, our research constructed a prognostic model which has excellent prediction performance for overall survival of ES patients.
Severe Neuroinflammatory Relapse After Extrauterine Pregnancy and Abortion: A Case Report on a Patient With Heterogenic Ms Phenotype Carrying Myelin Oligodendrocyte Glycoprotein Autoantibodies
Authors: Kulmala Katja , Vaitiniemi Roosa , Blad Helene , Karrenbauer Virginija Danylaite 
Published: May 2021

Abstract
Background. Pregnancy has disease-modifying effects in MS. First trimester abortion might be followed by increased MS activity. MS with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is a rare and agressive disease variant. Objectives. This case illustrates severe inflammatory reactivation after surgical abortion in MS patient who carries MOG antibodies. Methods. Case-report. Patient provided written informed consent for information and images to be published. Results. MRI and CSF biomarkers indicated high inflammatory activity post-abortion. Conclusions. Pregnancy termination in combination with MOG antibody carriership and termination of dimethyl fumarate treatment just prior abortion have had contributed to extensive reactivation of MS.
Design and Psychometric Properties of a Questionnaire for Assessing Sexual and Reproductive Health Needs of Married Adolescent Women: An Exploratory Sequential Mixed Methods Study
Authors: Ghiasi Ashraf , Keramat Afsaneh , Zayeri Farid , Farjamfar Maryam , Vakilian Katayon , Bagheri Leila 
Published: May 2021

Abstract
BackgroundTo date, there is no valid and reliable instrument to specifically evaluate the married adolescent women's SRH needs. Hence, the aim of this study was to develop and evaluate the psychometric properties of a questionnaire for assessing Iranian married adolescent women's SRH needs. MethodsThe current exploratory sequential mixed method study was performed in two phases. In the first phase, a preliminary questionnaire was developed based on in-depth interviews with 34 married adolescent women and 4 key informants as well as a comprehensive literature review. In the second phase, validity of the questionnaire was assessed using face, content, and construct validity and reliability of the questionnaire was assessed using internal consistency and test-retest reliability.ResultsBased on qualitative content analysis and literature review, 137 items were extracted. After several modifications of the generated items, a 108-item questionnaire was prepared for the psychometric process. After checking face and content validity, 85 items remained in the study. In the exploratory factor analysis, eleven items were removed and the remaining 74 items were categorized into nine factors. The Cronbach's alpha coefficient and the Intraclass correlation coefficient were found to be 0.878 and 0.99 for whole scale, respectively.Conclusions The 74-item questionnaire has acceptable validity and reliability. Therefore, it can be used as an appropriate instrument for assessing married adolescent women's SRH needs.
Final Height in Pubertal Short Stature Boys Treated with GH Combination with Letrozole: A retrospective study
Authors: Ma Yaping , Jia Ruofan , Xia Bingyang , Tang Bin , Xu Zhuangjian 
Published: May 2021

Abstract
BackgroundThe growth potential of pubertal short stature boys is limited by the effect of estrogen on epiphyseal fusion. This study aims to identify the efficacy and safety of growth hormone (GH) combination with letrozole on final adult height (FAH) in pubertal short stature boys. MethodsThis is a retrospective study. Among pubertal short stature boys who treated with GH and letrozole were be followed up in our hospital, 20 cases reached FAH. ResultsBaseline chronological age were 12.12±1.14yr, bone age were 13.00±0.93yr. The treatment duration was 1.94±0.67yr. The height standard deviation score for bone age was increased from -1.46±0.51 to -0.12±0.57 (p<0.000). The predicted FAH before treatment, predicted FAH after treatment, FAH, and genetic target height were 161.02 ±4.12 cm, 172.11±4.20 cm, 172.67±2.72cm and 167.67±3.56 cm, respectively. There was significant differences between predicted FAH before treatment and after treatment (p<0.000), as well as predicted FAH before treatment and genetic target height (p<0.000).The predicted FAH after treatment was higher than that of genetic target height (p<0.001), as well as FAH and genetic target height (p<0.000). Conclusions﻿The GH combination with letrozole can enhance the FAH in pubertal short stature boys. No significant side effects were observed.
Liver Transplantation Is Highly Effective in Children With Irresectable Hepatoblastoma
Authors: Moosburner Simon , Schmelzle Moritz , Globke Brigitta , Schöning Wenzel , Eggert Angelika , Seika Philippa , Kästner Anika , Pratschke Johann , Öllinger Robert , Gül-Klein Safak 
Published: May 2021

Abstract

IntroductionIn children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. Aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblastoma. Materials and methodsRetrospective analysis of all patients treated surgically for hepatoblastoma from January 2000 till December 2019. Demographic and clinical data were collected before and after surgery. Primary endpoints were disease free survival and patient survival.ResultsIn total, 38 patients were included into our analysis (n=28 for LR, n=10 for LT) with a median follow up of 5 years. 36 patients received chemotherapy prior to surgery. Total hospital stay and intensive care unit (ICU) stay were significantly longer within the LT vs. the LR group (ICU 23 vs. 4 days, hospital stay 34 vs. 16 days, respectively; p < 0.001). Surgical complications (≤ Clavien-Dindo 3a) were equally distributed in both groups (60% vs. 57%; p =1.00). Severe complications (≥ Clavien-Dindo 3a) were more frequent after LT (50% vs. 21.4%; p = 0.11). Recurrence rates were 7% for LR and 0% for LT at 5 years after resection or transplantation (p=. Overall, 5-year survival was 90% for LT and 96% for LR (p = 0.44). ConclusionIn unresectable cases, liver transplantation reveals excellent outcomes in children with hepatoblastoma with an acceptable number of perioperative complications.
Breastfeeding-Friendly Policies And Programs In Selected Public Universities In Ghana
Authors: Gbagbo Fred Yao , Nkrumah Jacqueline 
Published: May 2021

Abstract
Background The United Nations through its Sustainable Development Goals 3 and 5 has championed Women empowerment for exclusive breastfeeding through various action plans and expected the concept to be decentralized through locally mandatory implementation of various institutional policies and programs in member Countries. Using Kabeer’s empowerment concept, the authors in this paper assessed the availability and implementation of breastfeeding policies and programs in selected public universities in Ghana. MethodsThe study design was an integration of descriptive, exploratory, and case study using an unstructured interview guide developed by the authors for qualitative data collection. Thematic analysis of data on breastfeeding experiences was done yielding three main categories (breastfeeding policy and programs, support, and views on breastfeeding) emerged during data analysis. The in-depth interviews of respondents lasted 60 minutes. The University of Cape-Coast Ethics Review Board gave ethical approval for the study. ResultsAlthough Ghana has ascribed to various international conventions on childcare and developed policies enshrined in its labour law to support breastfeeding, none of the universities in this study has a formal breastfeeding/childcare policy/program and there are no future policy plans for on-campus facilities to enhance breastfeeding. Financial cost emerged as a major challenge hindering the universities from implementing a policy/program in this regard, hence nursing mothers continue to make personal but challenging arrangements for breastfeeding on university campuses.Conclusions The finding that formal breastfeeding-friendly policy/program was unavailable in the various universities in Ghana reflects negative implications for childcare, hence achieving the Sustainable Development Goals 3 and 5 in Ghana. The authors recommend formal breastfeeding-friendly policies/programs as a criterion for accreditation of universities in Ghana to enhance childcare.
WITHDRAWN: Toxicity Investigation of Nano-SiO2 on Male Reproductive System in Pubertal Mice
Authors: Sun Fanli , Wang Xuying , Zhang Pinzheng , Chen Ziyun , Guo Zhiyi , Shang Xuan 
Published: May 2021

Abstract
BackgroundPuberty is a crucial stage to gain reproductive capacity, but it is also a period vulnerable to exogenous materials. While exposure to nanoparticles (NPs) has been linked to toxic responses in reproductive system in previous findings, little is known about the age-dependent effect of NPs, let alone the underlying mechanism. In the present study, we assessed male fertility parameters and explored its mechanism following intraperitoneal exposure to Nano-Silicon dioxide (Nano-SiO2) in mice during puberty.Methods40 mice aged 5 weeks were divided into 2 groups after 1 week acclimation and then exposed to 40mg/kg Nano-SiO2 dissolved in saline or vehicle controls by intraperitoneal injection every day over a period of 7-day, respectively. Changes in the structure and function of male reproductive organs were detected after exposure.ResultsNano-SiO2 exposed through intraperitoneal injection could cause damage to the testicular and epididymal histological architecture and reduce the level of sex hormone (testosterone), leading to a decrease in sperm quality and quantity. Furthermore, Nano-SiO2 could induce oxidative stress and inflammation in male reproductive tissues, indicated by reduced activity of antioxidants (superoxide dismutase, SOD) and increased level of the lipid peroxidation marker (malondialdehyde, MDA), which leads to the activation of cell apoptosis.Conclusion﻿Exposure to Nano-SiO2 in pubertal mice could cause toxicity on male reproductive system via inducing oxidative stress and activating TNF-α mediated apoptotic pathway.
Sex hormone dysregulations are associated with disease severity in critically ill male COVID-19 patients - a retrospective analysis
Authors: Schroeder Maria , Schaumburg Berfin , Mueller Zacharias , Parplys Ann , Jarczak Dominik , Roedl Kevin , Nierhaus Axel , de Heer Geraldine , Grensemann Joern , Schneider Bettina , Stoll Fabian , Bai Tian , Jacobsen Henning , Zickler Martin , Stanelle-Bertram Stephanie , Klaetschke Kristin , Renne Thomas , Meinhardt Andreas , Aberle Jens , Hiller Jens , Peine Sven , Kreienbrock Lothar , Klingel Karin , Kluge Stefan , Gabriel Guelsah 
Published: May 2021

Abstract
BACKGROUNDMale sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. We sought to characterize sex differences in hormone levels and cytokine responses in critically ill COVID-19 patients.METHODSWe performed a retrospective cohort study of critically ill COVID-19 patients. Males and females were compared. Multivariate regression was performed to assess the association between sex hormones, cytokine responses and the requirement for extracorporeal membrane oxygenation (ECMO) treatment.RESULTSWe analyzed sex hormone levels (estradiol and testosterone) of n=181 male and female individuals. These consisted of n=50 critically ill COVID-19 patients (n=39 males, n=11 females), n=42 critically ill non-COVID-19 patients (n=27 males, n=15 females), n=39 non-COVID-19 patients with coronary heart diseases (CHD) (n=25 males, n=14 females) and n=50 healthy individuals (n=30 males, n=20 females). We detected highest estradiol levels in critically ill male COVID-19 patients compared to non-COVID-19 patients (p=0.0123), patients with CHD (p=0.0002) or healthy individuals (p=0.0007). Lowest testosterone levels were detected in critically ill male COVID-19 patients compared to non-COVID-19 patients (p=0.0094), patients with CHD (p=0.0068) or healthy individuals (p<0.0001). No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends in estradiol levels were observed. In critically ill male COVID-19 patients, cytokine and chemokine responses (IFN-γ, p=0.0301; IL-1RA, p=0.0160; IL-6, p=0.0145; MCP-1, p=0.0052; MIP-1α, p=0.0134) were significantly elevated in those with higher Sequential Organ Failure Assessment (SOFA) scores (8-11). Linear regression analysis revealed that herein IFN-γ levels correlate with estradiol levels in male and female COVID-19 patients (R2=0.216, =0.0009). Male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment in the course of their ICU stay (p=0.0009). CONCLUSIONS We identified high estradiol and low testosterone levels as a hallmark of critically ill male COVID-19 patients. Elevated estradiol levels in critically ill male COVID-19 patients were positively associated with IFN-γ levels and increased risk for ECMO requirement.
3D Printing Individualized Assisted Repair and Reconstruction of Irregular Bone Neoplastic Bone Defects: Exploration and Practice in Scapular Aneurysmal Cystic Bone Defects
Authors: Luo Guochen , Zhang yao , Wang Xiahua , Chen Shuaishuai , Li Dongyi , Yu Mingyang 
Published: May 2021

Abstract
Objective: To explore the clinical efficacy of using 3D printing individualized treatment plan in the auxiliary repair and reconstruction of irregular bone tumor bone defect.Methods：Seven patients with aneurysmal bone cyst of scapula were selected. Based on the CT data of the patient, the scapula (including defect) and pelvis were reconstructed by computer Mimics Medical software. Print out the reconstructed scapula model with a 3D printer. Before operation, the model was used to design the surgical approach and simulate the operation process, to determine the length and Radian of the plate and the number and direction of screws, and to determine the bone mass of the ilium and make reasonable segmentation and distribution. The operation time, the amount of bleeding, the length and Radian of the plate, and the direction and number of screws were recorded.Results : The average follow-up time was 25.6 months, and none of the 7 patients had recurrence during the follow-up period; The surgical approach, the length and Radian of the internal fixation, the number and direction of screws were consistent with the designed operation plan. The anatomical structure of scapula and the function of shoulder joint gradually recovered.Conclusions: Compared with traditional methods, the use of 3D printing technology in the treatment of irregular bone tumor bone defect has less trauma, shorter operation time and less bleeding, which can reduce the waste of bone graft and reconstruct the anatomical structure of bone defect more completely.
Open Sub-Granting Radio Resources in Overlay D2D-Based V2V Communications
Authors: Soleymani Dariush Mohammad , Gholami Mohammad Reza , Galdo Giovanni Del , Mueckenheim Jens , Mitschele-thiel Andreas 
Published: May 2021

Abstract
Capacity, reliability, and latency are seen as key requirements of new emerging applications, namely Vehicle-to-Everything (V2X) and Machine Type Communication (MTC) in future cellular networks. Device-to-Device (D2D) communication is envisaged to be the enabler to accomplish the requirements for the applications as mentioned earlier. Due to the scarcity of radio resources, a hierarchical radio resource allocation, namely the sub-granting scheme, has been considered for the overlay D2D communication. In this paper, we investigate the assignment of underutilized radio resources from D2D communication to Device-to-Infrastructure (D2I) communication, which are moving in a dynamic environment. The sub-granting assignment problem is cast as a maximization problem of the uplink cell throughput. Firstly, we evaluate the sub-granting signaling overhead due to mobility in a centralized sub-granting resource algorithm, Dedicated Sub-Granting Radio Resource (DSGRR), and then a distributed heuristics algorithm, Open Sub-Granting Radio Resource (OSGRR) is proposed and compared with the DSGRR algorithm and no sub-granting case. Simulation results show improved cell throughput for the OSGRR compared with other algorithms. Besides, it is observed that the overhead incurred by the OSGRR is less than the DSGRR while the achieved cell throughput is yet close to the maximum achievable uplink cell throughput.