bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rat Ultrasonic Vocalizations as Social Reinforcers—Implications for a Multilevel Model of the Cognitive Representation of Action and Rats’ Social World
Authors: Kalenscher Tobias , Schönfeld Lisa-Maria , Löbner Sebastian , Wöhr Markus , van Berkel Mireille , Zech Maurice-Philipp , van Wingerden Marijn 
Published: May 2021

AbstractRats are social animals. For example, rats exhibit mutual-reward preferences, preferring choice alternatives that yield a reward to themselves as well as to a conspecific, over alternatives that yield a reward only to themselves. We have recently hypothesized that such mutual-reward preferences might be the result of reinforcing properties of ultrasonic vocalizations (USVs) emitted by the conspecifics. USVs in rats serve as situation-dependent socio-affective signals with important communicative functions. To test this possibility, here, we trained rats to enter one of two compartments in a T-maze setting. Entering either compartment yielded identical food rewards as well as playback of pre-recorded USVs either in the 50-kHz range, which we expected to be appetitive or therefore a potential positive reinforcer, or in the 22-kHz range predicted to be aversive and therefore a potential negative reinforcer. In three separate experimental conditions, rats chose between compartments yielding either 50-kHz USVs versus a non-ultrasonic control stimulus (condition 1), 22-kHz USVs versus a non-ultrasonic control stimulus (condition 2), or 50-kHz versus 22-kHz USVs (condition 3). Results show that rats exhibit a transient preference for the 50-kHz USV playback over non-ultrasonic control stimuli, as well as an initial avoidance of 22-kHz USV relative to non-ultrasonic control stimuli on trend-level. As rats progressed within session through trials, and across sessions, these preferences diminished, in line with previous findings. These results support our hypothesis that USVs have transiently motivating reinforcing properties, putatively acquired through association processes, but also highlight that these motivating properties are context-dependent and modulatory, and might not act as primary reinforcers when presented in isolation. We conclude this article with a second part on a multilevel cognitive theory of rats’ action and action learning. The “cascade” approach assumes that rats’ cognitive representations of action may be multilevel. A basic physical level of action may be invested with higher levels of action that integrate emotional, motivational, and social significance. Learning in an experiment consists in the cognitive formation of multilevel action representations. Social action and interaction in particular are proposed to be cognitively modeled as multilevel. Our results have implications for understanding the structure of social cognition, and social learning, in animals and humans.
An XMG Account of Multiplicity of Meaning in Derivation
Authors: Andreou Marios , Petitjean Simon 
Published: May 2021

AbstractIn this paper, we tackle the issue of multiplicity of meaning in derivation using Frame Semantics and eXtensible MetaGrammar (XMG). We use corpus extracted data to identify the range of readings -al derivatives exhibit and identify prominent constraints on the types of situations and entities -al targets. These constraints have the form of type constraints and specify which arguments in the frame of the verbal base are compatible with the referential arguments of the derivative. The introduction of these constraints into the semantics of an affix allows one to predict and generate those readings which are possible for a given derivative and, at the same time, rule out those readings which are not possible. Finally, as a proof of concept, we model these constraints using XMG, and check whether the output resulting of this XMG description is consistent with the range of readings observed in the corpus.
Make No Little Plans: The Lucian Leape Institute
Authors: Leape Lucian L. 
Published: May 2021

AbstractDespite encouraging progress in the early years of the patient safety movement, it soon became evident that there were deeper issues that needed to be addressed. We realized that we were not going to make health care safe by making process changes one by one, even powerful changes such as eliminating CLABSI or implementing the surgical checklist.
Who Will Lead? The Executive Session
Authors: Leape Lucian L. 
Published: May 2021

AbstractA few weeks after the Annenberg Conference, Saul Weingart called me on the phone, introduced himself and said, “We should do an Executive Session on medical errors.” “What is an Executive Session?” I replied. He then told me about the work he had been involved in at the Harvard Kennedy School of Government (HKS) on juvenile justice and community policing. Developed in the late 1970s at HKS, an executive session is a prolonged confidential conversation among leaders in a practice field to solve a complex problem for which there is no evident technical solution.
Conclusion: Engineering Movies
Authors: Gowanlock Jordan 
Published: May 2021

AbstractThe conclusion to Animating Unpredictable Effects argues for the importance of understanding engineering and R&D as a part of animation and visual effects production, in opposition to critics who dismiss these as mere tools for hyperrealism. This provides for a better understanding of a diverse range of contemporary digital media production practices that involve extensive technical work, but it also sheds light on film production practices going back a century. Using the example of practical special effects, like puffs of smoke or splashing waves in a studio water tank, which create unpredictable motion under artificial conditions, the conclusion draws a long history of practices that represent the world by making artificial mechanisms rather than capturing or drawing images.
A substrate for brane shells from $$ T\overline{T} $$
Authors: Aguilera-Damia Jeremias , Anderson Louise M. , Coleman Evan 
Published: May 2021

Abstract
A solvable current-current deformation of the worldsheet theory of strings on AdS3 has been recently conjectured to be dual to an irrelevant deformation of the spacetime orbifold CFT, commonly referred to as single-trace $$ T\overline{T} $$
T

T
¯

. These deformations give rise to a family of bulk geometries which realize a non-trivial flow towards the UV. For a particular sign of this deformation, the corresponding three-dimensional geometry approaches AdS3 in the interior, but has a curvature singularity at finite radius, beyond which there are closed timelike curves. It has been suggested that this singularity is due to the presence of “negative branes,” which are exotic objects that generically change the metric signature. We propose an alternative UV-completion for geometries displaying a similar singular behavior by cutting and gluing to a regular background which approaches a linear dilaton vacuum in the UV. In the S-dual picture, a singularity resolution mechanism known as the enhançon induces this transition by the formation of a shell of D5-branes at a fixed radial position near the singularity. The solutions involving negative branes gain a new interpretation in this context.
Two-loop helicity amplitudes for gg → ZZ with full top-quark mass effects
Authors: Agarwal Bakul , Jones Stephen P. , von Manteuffel Andreas 
Published: May 2021

Abstract
We calculate the two-loop QCD corrections to gg → ZZ involving a closed top-quark loop. We present a new method to systematically construct linear combinations of Feynman integrals with a convergent parametric representation, where we also allow for irreducible numerators, higher powers of propagators, dimensionally shifted integrals, and subsector integrals. The amplitude is expressed in terms of such finite integrals by employing syzygies derived with linear algebra and finite field techniques. Evaluating the amplitude using numerical integration, we find agreement with previous expansions in asymptotic limits and provide ab initio results also for intermediate partonic energies and non-central scattering at higher energies.
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer
Authors: Tabassum Anika , Samdani Md. Nazmus , Dhali Tarak Chandra , Alam Rahat , Ahammad Foysal , Samad Abdus , Karpiński Tomasz M. 
Published: May 2021

Abstract
Transporter associated with antigen processing 1 (TAP1) is a transporter protein that represent tumor antigen in the MHC I or HLA complex. Any defect in the TAP1 gene resulting in inadequate tumor tracking. TAP1 influences multidrug resistance (MDR) in human cancer cell lines and hinders the treatment during chemotherapeutic. The association of TAP1 in cancer progression remains mostly unknown and further study of the gene in relation with cancer need to conduct. Thus, the study has designed to analyze the association between the TAP1 with cancer by computationally. The expression pattern of the gene has determined by using ONCOMINE, GENT2, and GEPIA2 online platforms. The protein level of TAP1 was examined by the help of Human Protein Atlas. Samples with different clinical outcomes were investigated to evaluate the expression and promoter methylation in cancer vs. normal tissues by using UALCAN server. The copy number alteration, mutation frequency, and expression level of the gene in different cancer were analyzed by using cBioPortal server. The PrognoScan and KM plotter platforms were used to perform the survival analysis and represented graphically. Additionally, pathway and gene ontology (GO) features correlated to the TAP1 gene were analyzed and presented by bar charts. After arranging the data in a single panel like correlating expression to prognosis, mutational and alterations characteristic, and pathways analysis, we observed some interesting insights that emphasized the importance of the gene in cancer progression. The study found the relationship between the TAP1 expression pattern and prognosis in different cancer tissues and shows how TAP1 affects the clinical characteristics. The analytical data presented in the study is vital to learn about the effect of TAP1 in tumor tissue, where previously studies showing contradicting expression of TAP1 in cancer tissue. The analyzed data can also be utilized further to evade the threats against chemotherapy. Overall, the study provided a new aspect to consider the role of TAP1 gene in cancer progression and survival status.

Key messages
• This study demonstrated, for the first time, a correlation between the TAP1 gene and tumor progression.
• An upregulation of TAP1 mRNA was demonstrated in various cancer types.
• This study reported a significant negative correlation for TAP1 gene expression and the survival rate in different cancer types.
Isolation of sesquiterpenoids from Matricaria chamomilla by means of solvent assisted flavor evaporation and centrifugal partition chromatography
Authors: Slavik Benedikt , Roehrer Simon , Loos Helene M. , Minceva Mirjana , Buettner Andrea 
Published: May 2021

AbstractThe (semi)volatile fraction of Matricaria chamomilla L., an annual herbal plant from the family of Asteraceae, contains high quantities of sesquiterpenes and sesquiterpenoids. A method was developed to achieve isolation and separation of these compounds, using a combination of solvent assisted flavor evaporation (SAFE) and solid support-free liquid-liquid chromatography. The biphasic liquid solvent system n-heptane/ethyl acetate/methanol/water, 5/2/5/2 v/v/v/v (Arizona S) was elaborated as a suitable solvent system for the simultaneous separation of the target compounds. The lab-scale liquid-liquid chromatography separation performed in a countercurrent chromatography (CCC) column was successfully transferred to a semi-preparative centrifugal partition chromatography (CPC) column, which enabled the isolation of artemisia ketone, artemisia alcohol, α-bisabolone oxide A, and (E)-en-yn-dicycloether. α-Bisabolol oxide A and (Z)-en-yn-dicycloether co-eluted, but were successfully separated by subsequent size-exclusion chromatography (SEC). Similarly, spathulenol and α-bisabolol oxide B were obtained as a mixture, and were separated by means of column chromatography using silica gel as stationary phase. The isolated compounds were characterized by means of nuclear magnetic resonance spectroscopy (NMR) and gas chromatography–mass spectrometry (GC-MS).
Graphical abstract
Ultra-high resolution 3D MRI for chondrocalcinosis detection in the knee—a prospective diagnostic accuracy study comparing 7-tesla and 3-tesla MRI with CT
Authors: Germann Christoph , Galley Julien , Falkowski Anna L. , Fucentese Sandro F. , Pfirrmann Christian W. A. , Nanz Daniel , Sutter Reto 
Published: May 2021

Abstract
Objectives
To test the diagnostic accuracy of a 3D dual-echo steady-state (DESS) sequence at 7-T MRI regarding the detection of chondral calcific deposits of the knee in comparison to 3-T MRI, using CT as cross-sectional imaging reference standard.

Methods
CT and 7-T MRI (DESS) of knee joints in 42 patients with radiographically known chondrocalcinosis (13 of 42 bilateral) were prospectively acquired for all included patients (n = 55 knee joints). Additionally, 3-T MRI (DESS) was performed for 20 of these 55 knee joints. Two fellowship-trained musculoskeletal radiologists scored eight cartilage regions of each knee joint separately regarding presence of cartilage calcification, diagnostic confidence level, and sharpness of calcific deposits. In an explorative subanalysis, micro-CT of the menisci was evaluated after knee arthroplasty in one patient. Diagnostic performance metrics and nonparametric tests were used to compare between modalities. p values < 0.05 were considered to represent statistical significance.

Results
Sensitivity for chondrocalcinosis detection was significantly higher for 7-T MRI (100%) compared to 3-T MRI (reader 1: 95.9%, p = 0.03; reader 2: 93.2%, p = 0.002). The diagnostic confidence was significantly higher for both readers at 7 T compared to both 3-T MRI (p < 0.001) and to CT (p = 0.03). The delineation of chondral calcifications was significantly sharper for 7-T compared to both 3-T MRI and CT (p < 0.001, both readers). Micro-CT in one patient suggested that 7-T MRI may potentially outperform standard CT in diagnosing chondral calcifications.

Conclusion
3D-DESS imaging at 7-T MRI offers a significantly higher sensitivity in detection of chondral calcific deposits compared to 3-T MRI.

Key Points
• 3D dual-echo steady-state (DESS) MRI at 7 T has a higher sensitivity in detection of chondral calcific deposits compared to 3-T MRI (p ≤ 0.03).
• 3D DESS MRI at 7 T yields no false-negative cases regarding presence of chondral calcific deposits.
• 3D DESS MRI at 7 T offers better delineation and higher diagnostic confidence in detection of chondral calcific deposits compared to 3-T MRI (p < 0.001).
A quantitative assessment of silicone and PTFE-based stamp techniques for restoring occlusal anatomy using resin-based composites
Authors: Klein Christian , von Ohle Christiane , Wolff Diana , Meller Christian 
Published: May 2021

Abstract
Objectives
Publications on stamp techniques for placing resin-based composite (RBC) restorations consist mainly of case studies. Furthermore, comparative studies are rare and no longer relevant to the materials tested today. Thus, two general techniques were investigated in this study.

Materials and methods
Standardized occlusion class I cavities were prepared in twenty-eight extracted caries-free wisdom teeth with unimpaired occlusal surfaces and restored with the RBC material Grandio®. Light curing of the final layer was performed either after removal of the stamp isolated with PTFE tape or by leaving a stamp made of transparent polysiloxane in place. CEREC scans of the RBC restorations placed (follow-up) were superimposed on scans of the unimpaired occlusal surface (baseline) and quantitatively analyzed with the software OraCheck with regard to volume change and gain or loss of layer thickness in six sectional planes.

Results
Assessing the excess material, there was no difference (p = 0.31) between the silicone technique (0.26 mm ± 0.02) and the PTFE technique (0.22 mm ± 0.02 mm). Nevertheless, the loss of tooth substance was significantly greater (p < 0.001) with the silicone technique (−0.29 mm ± 0.02 mm) than with the PTFE technique (−0.15 mm ± 0.02 mm).

Conclusions
With the PTFE stamp technique, less healthy tooth structure was removed during the finishing procedure and the stamp was more dimensionally stable.

Clinical relevance
The study shows the advantages and disadvantages of the investigated stamp techniques and helps the practitioner to choose an appropriate technique.
Similarity-based approaches in hydrogeology: proposal of a new concept for data-scarce groundwater resource characterization and prediction
Authors: Barthel Roland , Haaf Ezra , Giese Markus , Nygren Michelle , Heudorfer Benedikt , Stahl Kerstin 
Published: May 2021

AbstractA new concept is proposed for describing, analysing and predicting the dynamic behaviour of groundwater resources based on classification and similarity. The concept makes use of the ideas put forward by the “PUB” (predictions in ungauged basins) initiative in surface-water hydrology. One of the approaches developed in PUB uses the principle that similar catchments, exposed to similar weather conditions, will generate a similar discharge response at the catchment outlet. This way, models developed for well-observed catchments can be used to make predictions for ungauged catchments with similar properties (topography, land use, etc.). The concept proposed here applies the same idea to groundwater systems, with the goal to make predictions of the dynamic behaviour of groundwater in poorly observed systems using similarities to well-observed and understood systems. This paper gives an overview of the main ideas, the methodological background, the progress so far, and the challenges that the authors regard as most crucial for further development. One of the main goals of this article is thus to raise interest for this new concept within the groundwater community. There are a multitude of highly interesting aspects to investigate, and a community effort, as with PUB, is required. A second goal is to foster and exchange ideas between the groundwater and surface water research communities who, while often working on similar problems, have often missed the opportunity to learn from each other.
Does genetic anticipation occur in familial Alexander disease?
Authors: Hunt Camille K. , Al Khleifat Ahmad , Burchill Ella , Ederle Joerg , Al-Chalabi Ammar , Sreedharan Jemeen 
Published: May 2021

AbstractAlexander Disease (AxD) is a rare leukodystrophy caused by missense mutations of glial fibrillary acidic protein (GFAP). Primarily seen in infants and juveniles, it can present in adulthood. We report a family with inherited AxD in which the mother presented with symptoms many years after her daughter. We reviewed the age of onset in all published cases of familial AxD and found that 32 of 34 instances of parent–offspring pairs demonstrated an earlier age of onset in offspring compared to the parent. We suggest that genetic anticipation occurs in familial AxD and speculate that genetic mosaicism could explain this phenomenon.
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts
Authors: Alemany Silvia , Avella-García Claudia , Liew Zeyan , García-Esteban Raquel , Inoue Kosuke , Cadman Tim , López-Vicente Mònica , González Llúcia , Riaño Galán Isolina , Andiarena Ainara , Casas Maribel , Margetaki Katerina , Strandberg-Larsen Katrine , Lawlor Deborah A. , El Marroun Hanan , Tiemeier Henning , Iñiguez Carmen , Tardón Adonina , Santa-Marina Loreto , Júlvez Jordi , Porta Daniela , Chatzi Leda , Sunyer Jordi 
Published: May 2021

AbstractThe potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative study of six European population-based birth/child cohorts. A total of 73,881 mother–child pairs were included in the study. Prenatal and postnatal (up to 18 months) acetaminophen exposure was assessed through maternal questionnaires or interviews. ASC and ADHD symptoms were assessed at 4–12 years of age using validated instruments. Children were classified as having borderline/clinical symptoms using recommended cutoffs for each instrument. Hospital diagnoses were also available in one cohort. Analyses were adjusted for child and maternal characteristics along with indications for acetaminophen use. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis. The proportion of children having borderline/clinical symptoms ranged between 0.9 and 12.9% for ASC and between 1.2 and 12.2% for ADHD. Results indicated that children prenatally exposed to acetaminophen were 19% and 21% more likely to subsequently have borderline or clinical ASC (OR = 1.19, 95% CI 1.07–1.33) and ADHD symptoms (OR = 1.21, 95% CI 1.07–1.36) compared to non-exposed children. Boys and girls showed higher odds for ASC and ADHD symptoms after prenatal exposure, though these associations were slightly stronger among boys. Postnatal exposure to acetaminophen was not associated with ASC or ADHD symptoms. These results replicate previous work and support providing clear information to pregnant women and their partners about potential long-term risks of acetaminophen use.
‘I’m Outta Here’: Theorizing the Role of Exit in the Ideal of Non-Domination
Authors: Drugge Daniel 
Published: May 2021

AbstractAccounts of non-domination have tended to emphasise the role resources and other capacity and voice building mechanisms can play in giving people the power and the institutional means of living lives that are free of domination. Yet the role of exit - of institutionally protected means of withdrawing from relationships - has remained undertheorized in accounts of non-domination. Drawing on a range of public policy examples, this paper seeks to shed light on the ways in which, and under what conditions, institutionalised means of exit can contribute to realising the ideal of non-domination. It shows that while rights of exit and low exit-costs can play an essential role in protecting people from dependence on the arbitrary wills of others, it is only under certain conditions these can be said to contribute to the realisation of the ideal of non-domination in a broader sense. Understanding the relationship between exit and non-domination, it further argues, gives us a clearer (if more complicated) picture of the relationship between non-domination and sources of power such as monetary resources and voice.