bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFLUX MEDIATED MULTIDRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATED FROM DIFFERENT ENVIRONMENTAL SOURCES
Authors: AGU G. C. , THOMAS B. T. , SALAMI O. O. , POPOOLA O. D. 
Published: August 2021

Pseudomonas aeruginosa is an important opportunistic pathogen and one of the leading causes of multi-drug resistant nosocomial infections. This study was therefore carried out to determine the resistance nature, and the role of efflux pump in multidrug resistance of Pseudomonas aeruginosa isolated from different environmental sources using the efflux pump inhibitor, Carbonyl Cyanide 3-Chlorophenylhydrazone (CCCP). A total of 220 environmental samples were collected and processed following standard techniques. Susceptibility to antibiotics was performed using disc diffusion methods as described by the Clinical and Laboratory Standards Institute. Activity of the efflux pump system was carried out using the efflux pump inhibitor, CCCP. Results obtained identified 100 (45.5%) Pseudomonas aeruginosa and 72 (32.7%) other strains of Pseudomonas spp. The susceptibility testing revealed that all the identified strains of Pseudomonas aeruginosa that were subjected to susceptibility test were significantly resistant to ampicillin and cefotaxime, But the resistance profile of isolates to tetracycline, chloramphenicol, ceftriaxone, cefuroxime and perfloxacin were 93%, 72.1%, 79.1%, 58.1% and 51.2% respectively. However, imipenem was the most sensitive (100%), followed by cefepime (65%) and gentamicin (44%). Carbonyl Cyanide 3-Chlorophenylhydrazone decreased the minimum inhibitory concentration (MIC) of the isolates by 2 folds. Results obtained have shown the ubiquitous presence of multi-drug resistant P. aeruginosa from the environmental samples examined. Furthermore, it indicated the role of efflux pump in antibiotics resistance in P. aeruginosa isolates which indicate that P. aeruginosa strains from environmental sources could resist antibiotics by the efflux mechanism.
Towards Informed Use of the Pernkopf Atlas
Authors: Lax Leila 
Published: August 2021

Knowledge of the dark history and inherent ethical dilemmas of Pernkopf's atlas is essential to individual decisions on use. Seventy-five years after the Holocaust, the legacy of Pernkopf’s Atlas of Topographical and Applied Human Anatomy continues to unfold. Informed use of the atlas needs to be integrated in academia and in practice. This paper advocates for the adoption of The Vienna Protocol and improving informed use of the atlas by: (1) updating and inserting an information letter in as many volumes as possible, so that the history can be known before use; (2) conducting and publishing a research study within the medical art community, to examine knowledge of the history of the atlas and elevate awareness; and (3) creating a museum archive and permanent exhibition of the original anatomical illustrations, to document historical facts, disseminate visual evidence, and illuminate embedded controversies. Moving towards informed use, in these ways, provides opportunities for continued ethical discourse, personal reflection and future Holocaust education. Through informed use we memorialize and pay tribute to the Nazi victims portrayed in the atlas.
Image credit: Table of Contents image provided by the Medical University of Vienna, MUW-AD-003250-5-ABB-223.
HUBUNGAN BEBAN KERJA DENGAN STRES KERJA PERAWAT BERBASIS TEORI BURNOUT SYNDROME DI RUANG DAHLIA RSUD JOMBANG
Authors: Kristyaningsih Yuli , Wijaya Arif 
Published: August 2021

Pendahuluan Beban kerja sangat berkaitan dengan stres kerja, karena dengan meningkatnya beban kerja memungkinkan meningkatnya emosi perawat. Tujuan penelitian untuk mengetahui hubungan beban kerja dengan stres kerja perawat. Metode penelitian menggunakan desain cross sectional. Populasi semua perawat di ruang Dahlia RSUD Jombang dengan simple random sampling dan diperoleh sampel sebanyak 44 responden. Variabel independen yaitu beban kerja dan variabel dependen yaitu stres kerja perawat. Instrument penelitian dengan kuesioner dan analisa menggunakan spearman rank. Hasil penelitian sebagian besar perawat memiliki beban kerja ringan dengan 26 perawat (59,1%), stres kerja ringan sebagian responden dengan 27 perawat (61,4%), hampir setengahnya responden memiliki beban kerja ringan dengan stres kerja ringan dengan 27 perawat (61,4%). Kesimpulan beban kerja dengan stres kerja perawat di ruang Dahlia RSUD Jombang berbasis teori burnout syndrome rata-rata dalam kategori ringan, sehingga stres kerja ada hubungan antara beban kerja perawat, karena jika beban kerja terlalu sedikit ataupun banyak dapat memicu timbulnya stres pada perawat. Rekomendasi untuk beban kerja dengan stres kerja yang diberikan sebaiknya disesuaikan dengan profesinya dan kemampuan yang dimiliki perawat tersebut.
Kata Kunci : Beban Kerja, Stres Kerja, Perawat, Burnout Syndrome.
PENGARUH KOMPRES RIMPANG BANGLE (Zingiber Purpureum Roxb.) TERHADAP PENURUNAN INTENSITAS NYERI PADA PENDERITA OSTEOARTHRITIS (Dusun Lebak Kecamatan Malo Kabupaten Bojonegoro)
Authors: Hartini Hartini , Hariyono Hariyono , Indrawati Ucik 
Published: August 2021

Pendahuluan : Osteoarthritis merupakan penyakit tersering yang menyebabkan timbulnya nyeri dan disabilitas gerakan. Osteoarthritis lebih banyak ditemukan pada perempuan jika dibandingkan dengan laki-laki yaitu 68,67%. Osteoarthritis dapat menyerang semua sendi, namun predileksi yang tersering adalah pada sendi-sendi yang menanggung beban berat badan seperti panggul, lutut, dan sendi tulang belakang bagian lumbal bawah. Tujuan : Tujuan penelitian ini untuk menganalisis pengaruh kompres rimpang bangle terhadap penurunan intensitas nyeri osteoarthritis di Dusun Lebak. Metode : Desain penelitian Quasi eksperimen dengan one group pre test – post test desain jumlah populasi dalam penelitian ini adalah sebagian penderita oesteoarthritis di Dusun Lebak sejumlah 60, sampel 56 responden, menggunakan simple random sampling. Variabel independent kompres rimpang bangle (zingiber purpureum roxb.) dan variabel dependen penurunan intensitas nyeri osteoarthritis, pengumpulan data menggunakan lembar observasi. Uji statistiknya menggunakan uji statistic Wilcoxon. Hasil : Hasil penelitian tingkat intensitas nyeri osteoarthritis sebelum diberikan kompres rimpang bangle (zingiber purpureum roxb.) adalah sebagian besar nyeri berat sejumlah 46 responden (82,1%) . Tingkat intensitas sesudah diberikan kompres rimpang bangle (zingiber purpureum roxb.) adalah sebagian besar Nyeri sedang sejumlah 36 responden (63,4%). Berdasarkan uji Wilcoxon menunjukkan bahwa nilai signifikansi p=0,000 < α (0,05) , sehingga H0 ditolak dan H1 diterima. Kesimpulan : Kesimpulan ada pengaruh kompres rimpang bangle (zingiber purpureum roxb.) terhadap penurunan intensitas nyeri pada penderita osteoarthritis di Dusun Lebak Kecamatan Malo Kabupaten Bojonegoro. Saran : Dengan adanya penggunaan kompres rimpang bangle (zingiber purpureum roxb) diharapkan dapat membantu mengurangi intensitas nyeri pada penderita osteoarthritis di Dusun Lebak.
Kata Kunci : Osteoarthritis , Rimpang Bangle, Intensitas Nyeri
PENGARUH RELAKSASI PROGRESIF TERHADAP PENURUNAN TEKANAN DARAH TINGGI PADA LANSIA
Authors: Puspitasari Maharani Tri 
Published: August 2021

Hipertensi merupakan faktor risiko utama penyakit-penyakit kardiovaskuler yang menyebabkan kematian tertinggi di Indonesia. Relaksasi progresif merupakan intervensi untuk mengendalikan hipertensi yang tidak menimbulkan efek samping. Penelitian ini bertujuan untuk menjelaskan pengaruh relaksasi progresif terhadap penurunan tekanan darah tinggi pada lansia di UPT Pelayanan Sosial Lanjut Usia Kabupaten Jombang. Desain penelitian ini menggunakan (Pre-Experimental) dengan pendekatan one-group pra test-post test desaign. Variable dependennya adalah tekanan darah tinggi, sedangkan variable independennya adalah relaksasi progresif. Pengambilan sample dengan menggunakan teknik Purposive Sampling, jumlah populasi sebanyak 32 responden dan jumlah sampel sebanyak 20 responden. Untuk menguji pengaruh relaksasi progresif antar variabel menggunakan uji statistic wilcoxon tingkat kemaknaan α = 0,05. Berdasarkan uji statistik wilcoxon dengan tingkat signifikan α = 0,05, untuk tekanan darah setelah observasi hari ketiga didapatkan nilai signifikan ρ =0,000 (α<0,05) sehingga Ho ditolak, berarti ada pengaruh relaksasi progresif terhadap tekanan darah pada pasien hipertensi. Disimpulkan ada pengaruh pemberian relaksasi progresif terhadap penurunan tekanan darah tinggi pada lansia di UPT Pelayanan Sosial Lanjut Usia Kabupaten Jombang. Sehingga relaksasi progresif dapat digunakan sebagai intervensi untuk menurunkan tekanan darah tinggi pada lansia.
Kata Kunci: Lansia, Relaksasi Progresif, Tekanan Darah Tinggi
Fatal Complications of Nasogastric Tube Misplacement in Two Dogs
Authors: Rodriguez-Diaz Jenniffer , Sumner Julia P. , Miller Meredith 
Published: August 2021

ABSTRACT
Provision of enteral nutrition via the use of nasoenteric feeding tubes is a commonly used method in both veterinary and human medicine. Although case reports in human medicine have identified fatalities due to misplacement of nasogastric (NG) tubes into the tracheobronchial tree and subsequent pneumothorax, there are no case reports, to our knowledge, of fatalities in veterinary patients. This case report describes two fatalities caused by misplaced NG tubes in intubated patients (one intraoperative, one postoperative). This report highlights risk factors for feeding tube complications and methods to prevent future fatalities such as two-view radiography, two-step insertion, capnography, laryngoscopic-assisted placement, and palpation of the NG tube in the stomach. The recent fatalities discussed within this case series demonstrate that deaths as a result of NG tubes misplaced into the tracheobronchial tree occur in veterinary patients, and measures should be taken to prevent this complication.
An Analysis of the Teachers’ Strategies in Teaching English Vocabulary at the Seventh Grade of Mts N 7 Kebumen in the Academic Year 2019/2020
Authors: Garwan Hellaisna Nur'Aini , Priyanti Henny 
Published: August 2021

Teaching vocabulary is one way to increase students' knowledge so they can make grammatical sentences. Teaching vocabulary must also be equipped with strategies that are suitable for students. Many strategies can be used by teachers. In vocabulary, there are many things that must be equated and good handling must be taken so that students can understand what vocabulary is. This research was conducted at MTs N 7 Kebumen. The subjects of this study were the English teachers in seventh grade. The purpose of this research is to find the strategies used by English teachers in teaching vocabulary. This research find out students' responses toward the application of teachers' strategies in teaching vocabulary to seventh grade students of MTs N 7 Kebumen. In the interview with an English teacher at MTs N 7 Kebumen, the researcher found out some obstacles experienced by the teacher. One of the obstacle was students have little vocabulary. Therefore the teacher used strategies which easily accepted by students. The teacher also felt not easy to teaching English. This research discusses about analysis the teachers’ strategies in teaching English vocabulary. This research method used descriptive qualitative to describe the strategy of English teachers in teaching vocabulary. The research focused on the strategies of the English teacher in teaching vocabulary in the classroom. The researcher used interview, docummentation, and questionnaire for data collection techniques. First, the researcher interviewed with English teacher. Second, the researcher conducted data analysis using pictures, lesson plans and syllabus as data docummentation. Third, the researcher also gave questionnaires to students in seventh grade MTs N 7 Kebumen using Google Forms. Based on the analysis, the results of the research are three findings that can be taken. First, there are some strategies used by teachers to teach vocabulary, namely presentation, translation, memorization, playing games, reading, pantomime, action, and body movements. Second, this research found out the media used to convey the material, the media used are real things, videos, pictures, English books of students. Third, the researcher found out students' responses with strategies used by the teacher. The researcher concluded that students can enjoy teaching and learning that the teacher gives. By using presentations, translations, memorization, playing games, words, mime, actions, and movements. Students also can remember new words more easily.
Keyword: Strategies, Students, Teachers, Teaching, Vocabulary
Ruptures et continuités de la personne
Authors: Simon Lionel 
Published: August 2021

Deux thèses en apparence antinomiques ont été développées pour rendre compte des traitements funéraires pratiqués dans les basses terres d’Amérique du Sud. L’une soutient l’idée que la coupure entre morts et vivants constitue le motif des pratiques mortuaires. L’autre pointe au contraire le souci de prolonger la continuité entre la personne disparue et ce qu’elle était de son vivant. À travers un examen des cérémonies funèbres, mais aussi des usages que les défunts suscitent, le cas des Wayùu de Colombie met en évidence une posture intermédiaire, qui oscille entre l’abolition et la conservation des morts, entre la préservation du souvenir et l’oubli. Cette ambivalence traduit un souci notable pour l’allégresse des yoluja, forme que prennent les individus après leur trépas. Dans cet article, ceux-ci sont notamment appréhendés à travers les « territorialisations » dont ils sont l’objet et les propriétés ontologiques qui leur sont prêtées. Il s’agit de montrer que le socle paradigmatique qui suppose l’existence de deux stades de mortalité – et l’anonymisation de la personne selon une temporalité calquée sur le processus biologique de décomposition des corps – autorise une variété d’articulations entre rupture et continuité. Les développements proposés entendent aussi de mettre en évidence le fait que, pour comprendre ces articulations, il est salutaire d’inscrire les pratiques funéraires dans un complexe relationnel plus large, qui relie les vivants et « leurs morts ».
Il paesaggio sonoro nella composizione musicale. Un percorso bibliografico
Authors: Alessandretti Stefano 
Published: August 2021

Over the last few decades there has been a proliferation of different fields of study directly derived from what can now be defined as a real discipline: the soundscape. Because of the growing number of new subjects, it becomes really challenging to get out of the multitude of publications, authors and terminologies, in order to create a synthetic and exhaustive bibliography dealing with the primary subject from which the various fields of study branched out. Starting from this difficulty this work was born, a bibliographic research aiming to direct the reader towards a targeted literature in the field of soundscape and music composition.
An automated method to enrich consumer health vocabularies using GloVe word embeddings and an auxiliary lexical resource
Authors: Ibrahim Mohammed , Gauch Susan , Salman Omar , Alqahtani Mohammed 
Published: August 2021

Background
Clear language makes communication easier between any two parties. A layman may have difficulty communicating with a professional due to not understanding the specialized terms common to the domain. In healthcare, it is rare to find a layman knowledgeable in medical terminology which can lead to poor understanding of their condition and/or treatment. To bridge this gap, several professional vocabularies and ontologies have been created to map laymen medical terms to professional medical terms and vice versa.

Objective
Many of the presented vocabularies are built manually or semi-automatically requiring large investments of time and human effort and consequently the slow growth of these vocabularies. In this paper, we present an automatic method to enrich laymen’s vocabularies that has the benefit of being able to be applied to vocabularies in any domain.

Methods
Our entirely automatic approach uses machine learning, specifically Global Vectors for Word Embeddings (GloVe), on a corpus collected from a social media healthcare platform to extend and enhance consumer health vocabularies. Our approach further improves the consumer health vocabularies by incorporating synonyms and hyponyms from the WordNet ontology. The basic GloVe and our novel algorithms incorporating WordNet were evaluated using two laymen datasets from the National Library of Medicine (NLM), Open-Access Consumer Health Vocabulary (OAC CHV) and MedlinePlus Healthcare Vocabulary.

Results
The results show that GloVe was able to find new laymen terms with an F-score of 48.44%. Furthermore, our enhanced GloVe approach outperformed basic GloVe with an average F-score of 61%, a relative improvement of 25%. Furthermore, the enhanced GloVe showed a statistical significance over the two ground truth datasets with P < 0.001.

Conclusions
This paper presents an automatic approach to enrich consumer health vocabularies using the GloVe word embeddings and an auxiliary lexical source, WordNet. Our approach was evaluated used healthcare text downloaded from MedHelp.org, a healthcare social media platform using two standard laymen vocabularies, OAC CHV, and MedlinePlus. We used the WordNet ontology to expand the healthcare corpus by including synonyms, hyponyms, and hypernyms for each layman term occurrence in the corpus. Given a seed term selected from a concept in the ontology, we measured our algorithms’ ability to automatically extract synonyms for those terms that appeared in the ground truth concept. We found that enhanced GloVe outperformed GloVe with a relative improvement of 25% in the F-score.
Antioxidant Activities and Hepatoprotective Potential of Ethanol Leaf Extract of Justicia quinqueangularis against Selected Hepatotoxins Induced Hepatotoxicity in Albino Wistar Rats
Authors: Suresh K. , Ahad Hindustan Abdul , Satyanarayana S. V. 
Published: August 2021

Background: The objective of this research was to see whether the ethanolic extract of Justicia quinqueangularis leaves had antioxidant and hepatoprotective properties against paracetamol (PCT), ethanol (ETN), and isoniazid and rifampicin (IR)-induced hepatotoxicity in Albino Wistar rats.
Methods: The leaves of Justicia quinqueangularis were dried in the shade at room temperature, pulverised, and extracted by soxhlet using ethanol. Quantitative phytochemical experiments were carried out as a first step. The ethanol extract's hepatoprotective activity was evaluated in Albino Wistar rats. PCT (3 g/kg), ETN (5 g/kg), and IR (100 mg/kg) reduced the levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin, which are all biochemical indicators of liver injury. Both hepatotoxin-treated and untreated group of animals determined for their antioxidant levels. SGOT, SGPT, ALP, bilirubin, antioxidant function of DPPH (2,2-diphenyl-1-picrylhydrazyl), hydrogen peroxide (H2O2), lipid peroxidation methods, hydroxyl radicals, and nitric oxide scavenging activities were among the biochemical and histopathological tests performed.
Results: The altered levels of biochemical markers were restored to near normal levels in a dose-dependent fashion after treatment with J. quinqueangularis ethanol leaf extract (100 mg / kg, 200 mg / kg, and 400 mg / kg body weight).
Conclusion: The findings of the current research indicated that the ethanol leaf extract of J. quinqueangularis had potent antioxidant and hepatoprotective properties against standard drug.
Evaluation of Antiepileptic Effect of Cleome viscosa Linn. Leaves Extract in Experimental Animals
Authors: Shakya Manish Kumar , Naseer Arif , Singh Ranjit 
Published: August 2021

Aim: The purpose of this study was to assess the antiepileptic effect of Cleome viscosa Linn. leaves extract in experimental animals.
Study Design: The extraction process, acute toxicity study was determined using OECD guidelines, Priliminary phytochemical screening, Antiepileptic pharmacological screening methods and statistical analysis.
Place and Duration of Study: The research work was conducted during 10 Jan. 2020 to 10 July 2020 at Dept. of Pharmacology, Rajiv academy for Pharmacy, Mathura (U.P), 281001, India.
Methodology: The fresh leaves were shade dried and reduced in size to powder and extracted by soxhlet apparatus. The MECV, CECV and AECV were prepared and subjected to comparative phytochemical profiling for in-vitro analysis. Further the in-vivo screening models like maximal electroshock induced seizures (MES), picrotoxin (PTX) and pentylenetetrazole (PTZ) induced models are used to assess the anti-epileptic effects of the methanol, chloroform and aqueous extracts of Cleome viscosa.
Results: The extracts were subjected to phytochemical tests and the carbohydrate, tannins, alkaloids, saponins, flavonoids, steroids and glycosides were found to be present. In the MES induced seizures, MECV (200 mg/kg) showed high significant inhibition on tonic hind limb extension (THLE) (9.33±0.33***), decrease in duration of stupor period (145.2 ± 2.59***) and decreased mortality significantly. In PTX induced model, MECV (200 mg/kg) showed high significant delay on the onset of convulsions (18.00±0.63***), decreased duration of convulsion (3.50 ± 0.18***) and decreased mortality significantly. In PTZ induced model, MECV and AECV (200mg/kg) showed high significant delay on the onset of convulsions (2.55 ± 0.10***), (2.50 ± 0.18***), decreased duration of convulsion (3.67 ± 0.11***), (4.33 ± 0.17**) and decreased mortality significantly.
Conclusion: It is clear from the preceding that Cleome viscosa has antiepileptic properties.
A Paradigm Shift in Ocular Drug Delivery to Posterior Segment: Review on Current Drug Delivery Approaches
Authors: Koduru Ravi Kumar , Kasaraneni Jigeesha , Juturi Ravi Kumar Reddy 
Published: August 2021

Objectives: Owing to the increasing number of patients suffering from posterior eye disorders, efficient medicine delivery to the posterior segment is now in great demand in the clinical services. With unmet medical requirements, the posterior eye segment is an important therapeutic target. So, physicians should be informed of new indications and current strategies of drug delivery when new technologies enter the market.
Summary: The most common causes of vision impairment in developed nations are abnormalities of the posterior eye tissues. Poor drug distribution to lesions in patient's eyes is a key barrier to ocular disease therapy. The existence of barriers, such as the corneal barrier, aqueous barrier, and inner and outer blood-retinal barriers, severely limits medication accessibility in these locations. Because of its anatomical peculiarities, the posterior portion is particularly difficult to access for medications. The use of several new strategies for drug delivery is therefore a viable option for enhanced therapy of ocular disorders since recent advances in ocular drug delivery systems research have brought fresh insights into drug development.
Conclusion: This article provides an overview of several aspects of ocular medication administration to the posterior region, with a focus on nano carrier-based approaches, suprachoroidal drug delivery system and ophthalmic devices, including the structure of the eye, its barriers, delivery routes, and the present status of drugs/devices.