bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life Cycle Assessment of Cogeneration Systems Using Raw and Torrefied Dichrostachys Cinerea (L.) Wight &amp; Arm. (Marabou).
Authors: Alba Yasmani , Pérez-Gil Maylier , Barrera Ernesto L. , Casas-Ledón Yannay , Arteaga-Pérez Luis Ernesto 
Published: August 2021

Abstract
Purpose This study aims to assess environmentally three different alternatives related to the valorization of Dichrostachys cinerea (L.) Wight & Arm. (marabou), identified as an invasive tree, as a feedstock for cogeneration facilities installed in the sugarcane industry in Cuba. The alternatives are (A-1) Electricity generation from marabou in a conventional back-pressure steam turbine cycle, (A-2) Electricity generation from torrefied marabou in a back-pressure steam turbine cycle, and (A-3) Electricity generation from torrefied marabou using extraction-condensing turbines.Methods SimaPro 9.0.0.35 software was used for the modeling of the inventory, based on different operational parameters. The ReCiPe environmental impact assessment method was used in the hierarchical perspective, assessing 18 impact categories (midpoint), and 3 damage categories (endpoint).Results and discussion The results demonstrated that A-3 shows the lower environmental impacts (Fine Particulate Matter Formation, Terrestrial Acidification, and Water Consumption) as compared to A-2 and A-1. This performance is explained by a lower normalized marabou consumption (1.85 kg marabou/kWh generated), and lower emissions associated with marabou harvesting, transportation, and processing. The cogeneration stage was the main contributor to the environmental burdens in Water Consumption (100% in A-1; 87% in A-2 and A-3). Marine Ecotoxicity was the impact category with better environmental performance due to the substitution of synthetic mineral fertilizers by ashes produced during combustion. The human health damage category reached the higher impacts on the torrefaction subsystem in the A-3 scenario, representing over 94% of the total environmental burden of the process. PM<10, NO2, and SO2 contributed the most over this damage category, mainly in marabou combustion, causing injuries in respiratory systems by aspiration of organic compounds.Conclusions The use of more efficient technology (extraction-condensing steam turbine), using torrefied marabou as feedstock, compared with the previous alternatives, impacts beneficially on the environment. Thus, a combination of marabou torrefaction with cogeneration facilities in sugarcane industries can be considered as an environmental-friendly technology in the Cuban context. The current study results will help decision-makers implement more sustainable policies in the Cuban energy sector, using marabou as feedstock as an attractive bioenergy route pathway.
Experiment On Fluid Regime Under Different Rotate Velocity In Physical Simulation of Titanium Vertical Centrifugal Casting
Authors: Yin Yajun , Peng Xin , Xiao Gen , Qie Xiwang , Shen Xu , Wan Peng , Ji Xiaoyuan , Zhou Jianxin 
Published: August 2021

Abstract
In this paper, the physical simulation of filling process of vertical centrifugal casting (VCC) of complex titanium alloy casting was studied. Combined with the mature PTV particle tracking technology, the high-speed photography pictures of the filling process of VCC at different rotational speeds were obtained. The trajectory and velocity information of tracer particles in the rotating flow field were obtained by the corresponding analysis software. Then, through the analysis and modeling of quantitative experimental data, the flow behavior characteristics and movement law of titanium alloy melt in the mold cavity under different mold speeds were studied. The results show that: 1. When the mold is still, the front edge of the filling fluid forms a curved surface with the curvature center pointing to the outside of the mold; when the mold rotates, the front edge of the liquid flow forms a curved surface with the curvature center pointing to the inside of the mold; 2. With the increase of the mold rotation speed, the speed of the fluid filling the mold increases significantly; when the rotational speed is greater than 120 rpm, the fluid still has a certain driving force in the mold center far away from the gate It is good for filling the inner corner of mold with fluid; 3. When the rotational speed of centrifugal casting of titanium alloy reaches 45 rpm or above, typical turbulent vortices appear in the wake; with the increase of rotating speed to 180 rpm, the average curvature radius of turbulent vortices first increases and then decreases, and reaches the minimum value of 0.67 cm at 120 rpm.
MicroRNA Signature in Papillary Thyroid Cancer; A Novel Diagnostic Panel
Authors: HONARDOOST MARYAM , Behnagh Arman Karimi , Hosseinkhan Nazanin , Abdolmaleki Fereshte , Panahi Mahshid , Maghsoomi Zohreh , Khamseh Mohammaf Ebrahim 
Published: August 2021

Abstract
Background

Detection of cancer in patients with thyroid nodule requires sensitive and specific diagnostic modalities that are accurate and inexpensive. The aim of this study was to identify potential microRNA panel to detect papillary thyroid carcinoma (PTC).
Method:

Following conducting differential expression analysis on stage 1 PTC and normal tissues available in TCGA, Real-time PCR was used to quantify the expression of candidate miRNAs in 59 tissue specimens from 30 patients with PTC and 29 patients with benign nodules. A receiver operating characteristic (ROC) curve analysis was used to access accuracy of miRNA expression levels compared to the pathology report as the gold standard.
Results

There was a significant difference between tissue expression level of miR-9, miR-20b, miR-222 and miR-221 in the PTC group Compared with non-PTC (P value < 0.05). The area under the curves were 1, 0.98, o.99, 0.98 and 1 irrespectively
Conclusion

A panel of miRNA including miR-20b, miR-222, miR-221 and miR-9 expression could be used as a useful to differentiate PTC from benign nodules.
Analysis of Characteristics Pigment And Paper Excavated At The Site of Hoeamsa Temple (12th-Century), Korea
Authors: Go InHee , Mun Seong Woo , Lee Jang Jon , Jeong Hye Young 
Published: August 2021

Abstract
One paper fragment and three pigments were excavated from earthenware found in the Hoeamsa Temple site (Historic Site No. 128), which is presumed to have been constructed in the 12th century. This study identifies the types and characteristics of the paper and pigments through methods such as fiber identification, pigment component analysis, and crystal structure analysis. Using the Graff 'C' staining method, the paper fragment is identified as paper-mulberry bast fiber (B. kazinoki Siebold), and according to radiocarbon dating results, the paper is believed to be from the Joseon Dynasty, between 1460 and 1640, which is when the Hoeamsa temple was believed to have been rebuilt. The green pigment consists of cerussite, malachite, and ataccamite, while quartz, muscovite, and illite were detected in the white pigment, and quartz, hematite, illite, and kaolinite were detected in the red pigment. The L* value ranged from 41.59 to 79.05. The white pigment showed the highest brightness value at 79.05, while the green pigment was measured at 58.20 and the red pigment at 41.59. The a* value ranged from -2.25 to 22.75: the a* value of the red pigment was the highest at 22.75, the green pigment was the lowest at -2.25. The b* value ranged from 7.44 to 26.26: the b*value of the red pigment was the highest at 26.26 and the white pigment was the lowest at 7.44.These scientific data identified the raw materials of paper used during the Joseon Dynasty. In addition, the data can be used for repair and restoration of ancient dancheong (traditional Korean decorative coloring on wooden buildings and artifacts) by analyzing the composition of pigments and identifying the characteristics of crystal structure.
Mechanism That Allows Manno-Oligosaccharide To Promote Cellulose Degradation By Microbes And Composting of Cow Manure With Straw
Authors: Zhang Yuhua , Duan Manli , Zhou Beibei , Wang Quanjiu , Zhang Zhenshi , Su Lijun , Bai Qingjun 
Published: August 2021

Abstract
New sugar source, manno-oligosaccharide, can regulate the structure of microbes. The effects of adding manno-oligosaccharide at four different levels (0, 0.1%, 0.5%, and 1% w/w compost) to cow manure–straw compost on the composting process, degradation of lignocellulose, and bacterial community in this study was investigated. The results showed that adding 0.5% manno-oligosaccharide had the greatest effects on accelerating the composting process, reducing the toxicity, and improving the stability of the product. After composting for 25 days, 0.5% oligosaccharide treatment can decrease the hemicellulose, cellulose, and lignin contents to 2.25%, 11.25%, and 7.07% respectively, compared with CK. Manno-oligosaccharide affected the distribution of the bacterial community, inhibited pathogenic bacteria, and improved the abundance of functional genes. Finally, adding 0.5% manno-oligosaccharide mainly affected the degradation of lignocellulose by enhancing the C/N value and the abundances of Streptomyces and the secretion system during composting was demonstrated by redundancy analysis.
Identifying The Factors Affecting ‘Patient Engagement’ In Exercise Rehabilitation
Authors: Teo Junsheng Leslie , Zheng Zhen , Bird Stephen Richard 
Published: August 2021

Abstract
Background
Despite the proven benefits of exercise rehabilitation for numerous health conditions, musculoskeletal injuries and recovery from surgery, patient adherence to such programs is reported to often be less than 35%. Increasing patient engagement therefore has the potential to improve patient health outcomes, benefiting the patient, their carers and the services that support them. The aims of this review were to identify the factors that contribute to ‘patient’ engagement in prescribed exercise rehabilitation using the COM-B (Capability, Opportunity, Motivation – Behaviour) framework of behavioural analysis.
Methods
Five electronic databases (PubMed, Embase, Cochrane, Web of Science, and ClinicalTrials.gov) were searched. ‘COM-B’ was the key word searched for specifically within titles and abstracts, combined with either ‘physical activity’ OR ‘exercise’ included using the ‘AND’ operation. Records were then filtered and excluded following full-text screening based on the predetermined eligibility criteria.
Results
Twenty studies were included in the review. The main COM-B themes highlighted for improving patient engagement were: Capability - improving patient knowledge and cognitive skills for behavioural regulation, such as ‘Action Planning’ and ‘Action Control’, which could also benefit time-management; Opportunity - a balanced life situation that enabled time to be devoted to the exercise program, social support, easily accessible and affordable resources and services; and Motivation - increasing patient levels of self-efficacy and autonomous motivation, which were noted to be influenced by levels of perceived ‘Capability’, additionally ‘Motivation’ was noted to be influenced by patients perceiving the benefits of the exercise, and adherence to the program was promoted by ‘goal-setting’. Other issues in the ‘Capability’ domain included a fear and/or dislike of exercise.
Conclusion
Patient engagement behavior has been shown to be influenced by both external (Opportunity) and intrapersonal variables (Capability and Motivation). Those prescribing exercises within a rehabilitation program need to discuss these factors with their patients and co-design the exercise rehabilitation program in partnership with the patient, since this is likely to improve patient engagement, and thereby result in superior health outcomes. Furthermore, these factors need to be a consideration in clinical trials, if the findings from such trials are to translate into mainstream healthcare settings.
N-Myc Promotes Angiogenesis and Therapeutic Resistance of Prostate Cancer by TEM8
Authors: Li MingFeng , Fang LinNa , KWANTWI LOUIS BOAFO , He GuiFang , Luo WenWu , Yang LiJie , Huang YuHang , Yin ShiYuan , Cai YongPing , Ma Wei , Zhan HeQin , Tong ZhuTing , Zhang Li , Yin Yu , Liang Chaozhao 
Published: August 2021

Abstract
Although patients with early localized prostate cancer can achieve a longer survival, castration-resistant prostate cancer (CRPC) has gradually developed with the use of androgen deprivation therapy (ADT). N-Myc and TEM8 play an important role in the progression of several cancer types. However, the underlying mechanism of how N-Myc and TEM8 promote the progression of prostate cancer remains unclear. In this study, the expression of N-Myc and TEM8 were detected in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) tissues by immunohistochemistry (IHC). To find the mechanism of prostate cancer resistance to treatment, LNCaP cell lines were maintained in RPMI 1640 medium supplemented with 10% Charcoal-stripped fetal Bovine Serum. Subsequently, R language software was used to verify our results. Tubule formation assay of human umbilical vein endothelial cell (HUVEC) was conducted to examine the effect of N-Myc and TEM8 overexpression on angiogenesis of prostate cancer cells.IHC results showed a positive correlation between the expression of N-Myc and TEM8 in prostate cancer tissues. Further analysis showed that N-Myc and TEM8 were associated with clinicopathological features and poor prognosis in prostate cancer patients. We found that the overexpression of N-Myc and TEM8 promotes proliferative ability and angiogenesis. Further, N-Myc and TEM8 overexpression was associated with therapeutic resistance. N-Myc promoted angiogenesis and therapeutic resistance in prostate cancer via TEM8. Hence, targeting N-Myc/TEM8 pathway in prostate cancer would be a novel therapeutic strategy to advance the treatment of prostate cancer patients.
Optimal Design of a Helical Coil Support for Dewars in Fuel Cell Applications
Authors: Nitin Baby , Sandilya Pavitra , Chakraborty Goutam 
Published: August 2021

Abstract
Fuel cells are gaining popularity because of their efficient energy production without causing environmental pollution. Recently DRDO, has developed a fuel cell-based fuel cell-based Air Independent Propulsion (AIP) system. In this system, the hydrogen is produced onboard while oxygen is carried in liquified form (LOX) from the land in specially designed insulated storage vessels called dewars. Such vessels are needed because LOX has low boiling point (NBP ~ 90K) and heat of vaporization (~213 kJ/kg) due to which it boils off easily even when there is small amount of heat inleak from the ambient. A typical dewar consists of two vessels separated by insulation. Support members are used to hold the two vessels together. Heat inleak through the supports and the insulation of the dewar causes the boiling of LOX. The vessels are subjected to dynamic loads during the voyage as well as due to the filling and consumption of LOX. Therefore, the support system should be designed so that it can withstand the dynamic loads experienced by the dewar. While the support system should have enough mechanical strength to withstand the loads it is subjected to, it should also restrict the heat inleak from the ambient to minimize the LOX boil-off. To meet this requirement, we need to optimize the support system design. Design optimization of support systems is especially critical in submarines to reduce the snorkeling frequency. Even though the dewars are available commercially for various applications, their design methodologies are not available in the open literature. Cylindrical rods are generally used as support members. In earlier studies, the authors have shown that helical coils give better thermal performance than tension rods as dewar supports. These two support systems involve different design criteria. It is important to evolve an optimal design of the support system to maximize the mechanical strength of the support while minimizing the heat inleak through the support. In this paper we are presenting a design methodology for optimizing a helical support. We have proposed a modified optimization technique derived from the classical genetic algorithm (GA) for this purpose. The modification has been done by ensuring design feasibility of the coil at each step of the algorithm. The proposed optimization technique has been tested on a LOX dewar and an optimal design of the helical coil support has been obtained.
Torsion In A Complete Bicorporeal Gravid Uterus: A Case Report
Authors: Khan Kimmee , Elfituri Abdullatif , Legit Christina , Doumouchtsis Stergios 
Published: August 2021

Abstract
PurposeBicorporeal uterus has a prevalence of 0.3% and can have significant implications in pregnancy. We encountered a patient in her third pregnancy with a bicorporeal uterus, having had two previous caesarean sections. This pregnancy was in the left hemi-uteri which was damaged during her previous delivery. We discuss the antenatal and intraoperative considerations undertaken. We also share her antenatal imaging and intraoperative photos of her pelvic anatomy.MethodsA comprehensive literature search was undertaken on PubMed revealing that uterine torsion in the context of a bicorporeal uterus in pregnancy is a rarely documented occurrence. We used the patient’s electronic obstetric notes for all her pregnancies as well as the computerised records of her imaging. Her caesarean section was electively planned and led by two experienced obstetric consultants and a senior registrar. Postnatally she was contacted for permission to publish the images from her scans and caesarean section. ResultsHer previous obstetric history was important and allowed a high index of suspicion for obstetric complications. Prediction of surgical complexities on antenatal screening and imaging was important in her case. Finally anticipation of possible intraoperative complications allowed for pre-operative planning. ConclusionThis case encompassing a series of learning points and surgical tips which has educational value as well as clinical interest. In the presence of a uterine abnormality, placental complications, extensions of incisions and vascular injury should be anticipated. A safe incision site must be identified before entering the uterine cavity. Therefore involvement of senior clinicians is essential.
Novel Conditioner For Efficient Dewaterability And Modification of Oily Sludge With High Water Content
Authors: Liu Biming , Teng Yue , Song Wenbin , Wu Haixia 
Published: August 2021

Abstract
The Oily sludge with high water content (OS) was dewatered, modified and converted into solid fuel by a novel chemical conditioner (OSO-101). The effect of OSO-101 dosage on the dewaterability of OS was studied, showing that OSO-101 dosage of 15% (wt.) could achieve the best dewaterability efficiency of OS (98.18%). Meanwhile, compared with some conventional conditioners, OSO-101 developed by our team was more effective in improving OS dewaterability efficiency. And OSO-101 may have free radical reaction, polar reaction and redox reaction with petroleum hydrocarbons in OS, thereby polymerizing and forming condensed solid structures. The calorific value change of OS after conditioning, heavy metal content and dioxins content of fly ash leached from incinerated product were measured for resource analysis and environmental assessment. Results showed that the resultant OS fuel blocks had extremely low content of heavy metals, dioxins and other toxic and hazardous substances leached from fly ash, thereby no secondary treatment and fully meeting environmental protection emission standards. Additionally, OSO-101 had certain economic rationality, and could effectively recover the calorific value contained in OS. This research is expected to provide new insights for efficient dewaterability and modification of OS, as well as subsequent resource utilization and harmless treatment, bringing potential environmental and economic benefits.
ASIC1a Stimulates the Resistance of Human Hepatocellular Carcinoma by Promoting Epithelial-mesenchymal Transition via the AKT/GSK3β/Snail Signaling Pathway
Authors: Zhang Yinci , Cao Niandie , Gao Jiafeng , Liang Jiaojiao , Liang Yong , Xie Yinghai , Zhou Shuping , Tang Xiaolong 
Published: August 2021

Abstract
Background: The main obstacle to the cure of hepatocellular carcinoma (HCC) is multidrug resistance. Acid sensing ion channel 1a (ASIC1a) acts as a critical roles in all stages of cancer progression, especially invasion and metastasis as well as in resistance to therapy. Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells transform into mesenchymal cells after being stimulated by extracellular factors and is closely related to tumor infiltration and resistance. Methods: Western blotting assay, Immunofluorescence (IF) staining, Immunohistochemistry (IHC) staining, MTT and colony formation assay and scratch healing assay were used to detect the level of ASIC1a and the cell proliferation, migration and invasion capabilities in this research.Results: In this research, we found that the protein of ASIC1a is overexpressed in HCC cancer tissues. In addition, we identified that the levels of ASIC1a are highly expressed in resistant HCC cells. Compared with the parental cells, EMT occurred more frequently in drug-resistant cells. Functional studies demonstrated that inactivation of ASIC1a restrained cell migration and invasion and enhanced the chemosensitivity of cells through EMT. In HCC cells, the overexpression of ASIC1a stimulates the up-regulation of EMT characterization molecular level and proliferation, migration and invasion capabilities and further induces drug resistance, while knocking down ASIC1a with short hairpin RNA (shRNA) has the opposite effect. Further investigations found that ASIC1a increased cell migration and invasion through EMT by regulating α and β-catenin, vimentin and fibronectin expression via AKT/GSK-3β/Snail pathway. Conclusions: Our study demonstrated that ASIC1a acts an important assignment in drug resistance of HCC through EMT via AKT/GSK-3β/Snail pathway, thereby lending a latent therapeutic objective and new ideas regarding to HCC.