bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Factors that Influence Potentially Inappropriate Medication Use among Thai Elderly in Primary Care Settings
Authors: Vatcharavongvan Pasitpon , Prasert Vanida , Ploylearmsang Chanuttha , Puttawanchai Viwat 
Published: December 2021

Background
Older age increases the likelihood of chronic diseases and polypharmacy with the likelihood of potentially inappropriate medications (PIMs) in secondary and tertiary care levels, but in the primary care settings of Thailand there still is a need for more evidence. This study aimed to examine the prevalence of PIM in primary care settings, and to identify factors that influence the use of PIM.
Methods
A cross-sectional retrospective study was conducted in 2017. Eight primary care units from four regions of Thailand were randomly selected. People aged ≥ 60 years in the eight units were studied as participants. The List of Risk Drugs for Thai Elderly (LRDTE) was used as the reference. Multivariate logistic regression was carried out to identify factors that influence.
Results
A total of 4,848 patients aged ≥60 years with 20,671 prescriptions were studied. The mean age was 70.7±8.3 years for males, and 61.2% for females. A little more than 5% (5.1%) had ≥ 3 chronic diseases and 15.0% received polypharmacy ( ≥5 medications). The prevalence of prescriptions with PIMs was 65.9%. The most frequent PIMs were antidepressants: amitriptyline (28.1%), antihistamines: dimenhydrinate (22.4%) and chlorpheniramine maleate (CPM) (11.2%); and Benzodiazepines: lorazepam (6.5%). Three factors that significantly influenced prescribing of PIMs were polypharmacy (adjusted OR 3.51; 95% CI 2.81-4.32), having ≥3 chronic diseases (adjusted OR 1.44; 95% CI 1.04-2.01), and age ≥75 years (adjusted OR 1.18; 95% CI 1.01-1.38).
Conclusion
More than two-thirds of elderly Thai patients in the primary care settings were prescribed PIMs. Multidisciplinary prescription review and PIM screening in patients aged ≥75 years who have ≥3 chronic diseases or polypharmacy should be implemented in primary care and supportive computerized PIMs alert system is needed.
Split-Flaps – a Way to Improve the Heel Stability of T-Foil Supported Craft
Authors: Prabahar N. S. S. , Persson A. , Larsson L. 
Published: November 2021

Abstract
Horizontal T-foils allow for maximum lift generation within a given span. However, the lift force on a T-foil acts on the symmetry plane of the hull, thereby producing no righting moment. It results in a lack of transverse stability during foil-borne sailing. In this paper, we propose a system, where the height-regulating flap on the trailing edge of the foil is split into a port and a starboard part, whose deflection angles are adjusted to shift the centre of effort of the lift force. Similar to the ailerons which help in steering aircraft, the split-flaps produce an additional righting moment for stabilizing the boat. The improved stability comes, however, at a cost of additional induced resistance.
To investigate the performance of the split-flap system a new Dynamic Velocity Prediction Program (DVPP) is developed. Since it is very important for the performance evaluation of the proposed system it is described in some detail in the paper. A complicated effect to model in the DVPP is the flow in the slot between the two flaps and the induced resistance due to the generated vorticity. Therefore, a detailed CFD investigation is carried out to validate a model for the resistance due to the slot effect.
Two applications of the split-flap system: an Automated Heel Stability System (AHSS) and a manual offset system for performance increase are studied using a DVPP for a custom-made double-handed skiff. It is shown that the AHSS system can assist the sailors while stabilizing the boat during unsteady wind conditions.
The manual offset enables the sailors to adjust the difference between the deflection angles of the two flaps while sailing, thus creating a righting moment whenever required. Such a system would be an advantage whilst sailing with a windward heel. Due to the additional righting moment from the manual offset system, the sails could be less depowered by the sailors resulting in a faster boat despite the additional induced resistance.
It is shown in the paper that the control systems for the ride height and the heel stability need to be decoupled. The paper ends with a description of a mechanical system that satisfies this requirement.
Les pratiques de lecture des élèves sénégalais
Authors: Kouakou Kouassi Sylvestre 
Published: November 2021

Notre étude avait pour objectif de dresser un panorama des pratiques de lecture des élèves au Sénégal. Elle s’est fondée sur une enquête par questionnaire menée auprès de 216 élèves. Elle a abouti à la conclusion que les élèves lisent ! Bien évidemment cette pratique est « imposée » par le cadre scolaire, mais aussi, elle est guidée par envie personnelle et pour le loisir. Ils lisent en moyenne entre 4 heures et 6 heures par semaine. Ils lisent le plus souvent des romans, des bandes dessinées, des magazines. Ils lisent avant tout pour s’occuper, et aussi pour s’évader, rêver, pour s’informer et se cultiver. L’environnement familial joue un rôle important dans le développement du goût de la lecture chez les adolescents. En effet, les élèves qui se perçoivent comme de grands lecteurs sont ceux dont les parents lisent beaucoup et qui disposent de livres en nombre relativement important à la maison. En général, les parents sont d’un niveau d’études post-secondaire et appartiennent à la catégorie sociale favorisée. Si le rôle de la bibliothèque scolaire dans la pratique de lecture des élèves a été quelque peu mis en évidence, celui du bibliothécaire n’a pas été clairement établi.
Projet Biblius : déployer le prêt de livres numériques dans les bibliothèques scolaires québécoises
Authors: Lusignan Nancy 
Published: November 2021

Depuis quelques années, on observe une hausse exponentielle des besoins pour l’accès aux oeuvres numériques dans le milieu scolaire québécois. Grâce à une initiative du ministère de l’Éducation du Québec, une plateforme de prêt numérique a été développée spécifiquement pour les bibliothèques scolaires québécoises : Biblius. On s’intéressera d’abord à la genèse du projet en définissant les besoins et enjeux soulevés par le milieu scolaire avant le déploiement de cette plateforme. On expliquera ensuite le fonctionnement de la plateforme et les différents volets du projet, ainsi que les solutions novatrices qui ont été proposées face aux problèmes rencontrés. Puis, les conclusions du déploiement restreint, réalisé au cours de l’année scolaire 2020-2021, seront présentées via les résultats de sondages et de consultations réalisés auprès des élèves, des enseignants participants et du personnel documentaire. Enfin, on amorcera une réflexion sur les défis que devront relever les bibliothèques scolaires québécoises, mais également l’ensemble des partenaires impliqués dans le déploiement de ce nouveau volet de la bibliothèque scolaire québécoise.
ANÁLISIS DE LA EVOLUCIÓN URBANA Y LA PELIGROSIDAD DE INUNDACIÓN EN EL TÉRMINO MUNICIPAL DE CASTELLÓ
Authors: Climent Mata Ruben , Segura Beltrán Francesca 
Published: November 2021

Los procesos de inundación son un fenómeno natural muy presente en las llanuras costeras valencianas, dado que en su mayoría han sido formadas por los ríos. Al pie de los relieves, los cursos fluviales han depositado abanicos aluviales, llanos de inundación y deltas, que han ido creciendo por sucesivas inundaciones. Estos espacios inundables, durante las últimas décadas, se han visto afectadas por una fuerte acción antrópica, que ha alterado los procesos naturales de inundación. En particular, la urbanización descontrolada en zonas inundables, ha aumentado la exposición y la vulnerabilidad y, por ende, el riesgo de inundación. La ciudad de Castelló ha sufrido un incremento de suelo urbano desde 1956 hasta día de hoy, provocando que muchas zonas urbanas se asienten en zonas inundables. Para analizar la peligrosidad de inundación se ha realizado un estudio diacrónico de la evolución urbana de Castelló y su término municipal. A los mapas resultantes se le han superpuesto las dos cartografías oficiales de peligro de inundación: el Plan de Acción Territorial sobre Prevención del Riesgo de Inundación en la Comunidad Valenciana (PATRICOVA) y el Sistema Nacional de Cartografía de Zonas Inundables (SNCZI). Los resultados indican que, desde los años 50, ha ido incrementando la superficie afectada por peligro de inundación –especialmente la asociada a periodos de retorno elevados--, aplicando los dos sistemas de cartografía, especialmente con el PATRICOVA. La zona que experimenta un mayor incremento es la Marjaleria, donde se ha producido un aumento de la urbanización ilegal. Sin embargo, este incremento se frena considerablemente a partir del año 2003, cuando se publica el PATRICOVA, que se ha mostrado como una herramienta eficaz para minimizar el riesgo de inundación.
First characterization of the probiotic potential of lactic acid bacteria isolated from Costa Rican pineapple silages
Authors: Wen Fang Wu Wu Jannette , Redondo-Solano Mauricio , Uribe Lidieth , WingChing-Jones Rodolfo , Usaga Jessie , Barboza Natalia 
Published: November 2021

Background
Agro-industrial waste from tropical environments could be an important source of lactic acid bacteria (LAB) with probiotic potential.

Methods
Twelve LAB isolates were isolated from pineapple silages. The species identification was carried out considering 16S rRNA and pheS genes. Experiments to evaluate the probiotic potential of the isolates included survival under simulated gastrointestinal environment, in vitro antagonistic activity (against Salmonella spp. and Listeria monocytogenes), auto-aggregation assays, antibiotic susceptibility, presence of plasmids, adhesiveness to epithelial cells, and antagonistic activity against Salmonella in HeLa cells.

Results
Lacticaseibacillus paracasei, Lentilactobacillus parafarraginis, Limosilactobacillus fermentum, and Weissella ghanensis were identified. Survival of one of the isolates was 90% or higher after exposure to acidic conditions (pH: 2), six isolates showed at least 61% survival after exposure to bile salts. The three most promising isolates, based on survivability tests, showed a strong antagonistic effect against Salmonella. However, only L. paracasei_6714 showed a strong Listeria inhibition pattern; this isolate showed a good auto-aggregation ability, was resistant to some of the tested antibiotics but was not found to harbor plasmids; it also showed a high capacity for adhesion to epithelial cells and prevented the invasion of Salmonella in HeLa cells. After further in vivo evaluations, L. paracasei_6714 may be considered a probiotic candidate for food industry applications and may have promising performance in acidic products due to its origin.
FEM: mining biological meaning from cell level in single-cell RNA sequencing data
Authors: Liu Yunqing , Lu Na , Bi Changwei , Han Tingyu , Zhuojun Guo , Zhu Yunchi , Li Yixin , He Chunpeng , Lu Zuhong 
Published: November 2021

Background
One goal of expression data analysis is to discover the biological significance or function of genes that are differentially expressed. Gene Set Enrichment (GSE) analysis is one of the main tools for function mining that has been widely used. However, every gene expressed in a cell is valuable information for GSE for single-cell RNA sequencing (scRNA-SEQ) data and not should be discarded.

Methods
We developed the functional expression matrix (FEM) algorithm to utilize the information from all expressed genes. The algorithm converts the gene expression matrix (GEM) into a FEM. The FEM algorithm can provide insight on the biological significance of a single cell. It can also integrate with GEM for downstream analysis.

Results
We found that FEM performed well with cell clustering and cell-type specific function annotation in three datasets (peripheral blood mononuclear cells, human liver, and human pancreas).
Lyophilized cell-free supernatants of Lactobacillus isolates exhibited antibiofilm, antioxidant, and reduces nitric oxide activity in lipopolysaccharide-stimulated RAW 264.7 cells
Authors: Sornsenee Phoomjai , Chatatikun Moragot , Mitsuwan Watcharapong , Kongpol Kantapich , Kooltheat Nateelak , Sohbenalee Sasirat , Pruksaphanrat Supawita , Mudpan Amron , Romyasamit Chonticha 
Published: November 2021

Background
Probiotics can release bioactive substances known as postbiotics, which can inhibit pathogenic microorganisms, improve immunomodulation, reduce antioxidant production, and modulate the gut microbiota.

Methods
In this study, we evaluated the in vitro antimicrobial effects, antioxidant activity, and anti-inflammatory potential of 10 lyophilized cell-free supernatants (LCFS) of Lactobacillus isolates. LCFS was obtained via centrifugation and subsequent lyophilization of the supernatant collected from the culture medium ofeach isolate. The antibacterial and antibiofilm activities of the LCFS were determined using broth microdilution. The antioxidant potential was evaluated by measuring the total phenolic and flavonoid contents and 2,2-Diphennyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS+) radical scavenging activities.

Results
All the isolates were able to inhibit the four tested pathogens. The isolates exhibited strong antibiofilm activity and eradicated the biofilms formed by Acinetobacter buamannii and Escherichia coli. All the prepared Lactobacillus LCFS contained phenols and flavonoids and exhibited antioxidant activities in the DPPH and ABTS+ radical scavenging assays. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay revealed that LCFS was not cytotoxic to RAW 264.7 cells. In addition, the ten Lactobacillus LCFS decreased the production of nitric oxide.

Conclusions
All the isolates have beneficial properties. This research sheds light on the role of postbiotics in functional fermented foods and pharmaceutical products. Further research to elucidate the precise molecular mechanisms of action of probiotics is warranted.
Analysis of Gastropod Diversity as a Bioindicator of Waters in Situ Ciburuy Padalarang, West Bandung Regency, West Java, Indonesia
Authors: Theofilius Erwin , Hasan Zahidah , Handaka Asep Agus , Hamndani Herman 
Published: November 2021

This study conducted to determine the water quality of Situ Ciburuy based on the structure of the gastropod community as a bioindicator. The survey method used in this study based on collecting data directly at the research area (purpose sampling method). For instance, species and density of gastropods were descriptively analyzed, using diversity index and evenes index. For instance, The findings showed that level of water quality in Situ Ciburuy based on gastropods bioindicators was lightly polluted. That is indicated by the low to moderate diversity of gastropods, which ranges from 1.31-1.98. The Shannon evenness index (0,73-0.95) revealed low gastropod species diversity in Situ Ciburuy, indicating low evenness of gastropod in Situ Ciburuy.
Transcatheter Closure of Atrial Septal Defect
Authors: Elsaka Omar 
Published: November 2021

Background: Over the past decade, percutaneous atrial septal defect (ASD) closure has been the preferred treatment option in many clinical programs for ASD. Percutaneous ASD closures with advanced device architecture and distribution have established user experience and process security. The ability to diagnose has also improved. The devices have evolved from the larger fixtures to the reset zone, being easily eliminated with little residual mesh material and comfortable fitting with the surrounding structures. Biodegradable technology has been introduced and will be considered as a future option. The emergence of the use of the ASD closure device over the last forty years includes improvements that reduce the incidence of adverse effects reported over the years. Issues reported in the literature include thrombus formation, air tightness, device insertion, abrasion, residual shunts and nickel hypersensitivity. Modern tools hold medium and long-term data with excellent results. Multi-sized devices securely close simple and complex ASDs that can re-scan, reset, and detect percutaneous advanced delivery procedures. In this review, the most widely used tools and distribution processes are discussed and the tools that show promise for the future.
Conclusion: As the field of transcatheter treatment of atrial septal defects (TC-ASD) and congenital interventional cardiology develops, real-world design studies provide valuable developmental information on aspects of care where there is disagreement about best practices and more research is needed.
Population Dynamics of Fall Armyworm, Spodoptera frugiperda (J. E. Smith) on Sorghum
Authors: Sunitha S. V. L. , Swathi M. , Madhumathi T. , Kumar P. Anil , Chiranjeevi C. H. 
Published: November 2021

The study on seasonal incidence of fall armyworm was carried out during kharif, 2019 at Agricultural college farm, Bapatla. The oviposition of fall armyworm was observed from 34th SMW (Standard Meterological Week) and reached its peak during 40th SMW (0.03 egg masses plant-1). The larval population of fall armyworm was commenced during 35th SMW and increased gradually to a peak of 1.67 larvae plant-1 during 41st SMW. The maximum plant infestation (60.00%) and leaf damage severity rating (3.13) of fall armyworm was observed during 41st SMW. The peak activity of natural enemies was observed during 41st SMW which coincides with the larval population of fall armyworm. The correlation analysis indicated that eggmasses of fall armyworm was positively correlated with minimum temperature(r= 0.668) and wind speed (r= 0.529) while, the larval population showed significant positive correlation with maximum temperature (r= 0.029). The plant infestation caused by fall armyworm had shown significant negative correlation with maximum temperature (r= -0.633) and positive correlation with morning relative humidity (r= 0.678) and evening relative humidity (r= 0.664) whereas, the leaf damage severity rating exhibited significant positive correlation with evening relative humidity (r= 0.691). The multiple regression analysis revealed that the influence of weather parameters on the incidence of fall armyworm and natural enemies in sorghum ecosystem was more than 65% and 40%, respectively.
Assisted Vaginal Delivery - Preference of Vacuum or Forceps among Obstetricians
Authors: Gnanasekaran Vijayalakshmi , Kanamma Shantha , Dhinakaran Shanthi , Kalaiselvi Jikki 
Published: November 2021

Objective: To determine the instrument preference among obstetricians practicing operative vaginal deliveries and to determine the prevalence and risks of vacuum or forceps Assisted Vaginal Delivery (AVD).
Methods: This cross-sectional study was carried out in ACS Medical and Hospital, Chennai. A total of 520 obstetricians were included in the study. An online questionnaire was sent to all obstetricians in Chennai. The choice of procedure for specific circumstances, instrument preference [use of vacuum or forceps] and views on the complications encountered in both vacuum and forceps use at vaginal delivery were explored. For the replies, we computed means and percentages for the entire group and distinct subgroups. Risk assessment of outcome with exposure as suitable p-value was included in the statistical analysis.
Results: Response rate for the questionnaire was 97% (504/520). The findings suggest that obstetricians preference was more towards vacuum due to their ease of usage. Baseline characteristics were similar between the two groups. Failed vacuum due to slipping of the cup was the most common complication faced - 62%, followed by caput succedaneum 25%, both were statistically significant. The most significant finding was that maternal injuries in the vacuum group were only 2% which was way less than those who had forceps delivery (68%) with a p-value of < 0.001.
Conclusion: In this research, physician instrument choice is a significant predictor of results that should be taken into account. Use of vacuum for delivery seemed to be the choice of majority of obstetricians [334 (66%)]. Vacuum extractor rather than forceps for assisted delivery appears to reduce maternal morbidity, whereas neonatal injuries were more common in newborns delivered by vacuum. The choice of instrument should be personalized based on the patient's condition and the obstetrician's experience and expertise.
Kellie Lodging, 23 High Street, Pittenweem, Fife
Authors: Lodge R Anthony 
Published: November 2021

The widely held view that Kellie Lodging (23 High Street, Pittenweem) was built as a townhouse for the Earls of Kellie cannot be correct. The stability of burgage plots in this part of the street shows a reliable match with 16th-century archival data, allowing identification of the occupants of the house at the time it was built (c 1585). Drawings made by Reverend John Sime in 1829 reveal a close historical association between this house and its neighbour at 19–21 High Street, demolished soon after his survey. The occupants of both houses were burgesses, living at a time of acute tension in the town between members of the laird class and the merchants. The siting of the houses at the head of Water Wynd, leading directly to the mid shore, reflects a shift in the town’s focus from the defunct religious area in the Augustinian priory towards a trade-oriented zone around the harbour. Kellie Lodging was the first in the street to have a projecting stair-tower, built not just for display but also for protection in dangerous times. It was quickly followed (1590) by the building of 19–21 with its own stair-tower directly abutting that of Kellie Lodging. Sime’s side-by-side plans of the two houses show the simple L-plan house of Kellie Lodging to be a less ambitious structure than 19–21, which had space to incorporate an inner courtyard to the rear. The street frontage symmetry of the two gables, with an unusual abutment of projecting stair-towers, can be read as a display of solidarity and resolution, as the merchants emerged as the dominant force in the burgh.
Canmore ID 34283