bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the Other Side of Complexity: Values and Decisions in a Time of Uncertainty
Authors: Knobel Marcelo 
Published: September 2021

AbstractHumanity is experiencing a moment of great uncertainty. This is not the first time a pandemic threatens the lives of millions of people. However, the speed with which governments and scientists are reacting to events is unprecedented. In an incredibly short time after the discovery of the virus, public health measures were implemented, and the development of defences in the form of public policies, medical therapies, and vaccines began. At this precarious moment, when the proliferation of information (and misinformation) from a variety of sources contribute to the spread of panic, universities and the scientific community emerge as the best and most reliable sources of information. It is only highly qualified specialists who can truly address the pandemic and its terrible economic, political, and public health consequences.
Africa’s Destiny and Higher Education Transformation
Authors: Nawangwe Barnabas 
Published: September 2021

AbstractAfrica, the cradle of mankind and civilization, presents the best example of a people falling from the most culturally and technologically advanced society to the most backward and marginalized. While other ancient civilizations like China, Babylon, and India either transformed and survived or persisted in the case of China, the Egyptian civilization was destroyed and was never to recover. The University of Sankore at Timbuktu, established in the 13th century and recognized by many scholars as one of the oldest universities on earth, is testimony to the advancement in scholarship that Africa had attained before any other civilization. But that is all history. Instead, Africa remains the most marginalized continent, viewed by many as a hopeless sleeping giant without any hope for awakening and moving forward as part of a modern global society.
The Changing Role of Universities in Lithuanian Society
Authors: Spurga Saulius , Žalėnienė Inga 
Published: September 2021

AbstractThe Lithuanian Republic was re-established on 11 March 1990 after the fall of the USSR, marking the beginning of a wave of reforms in the country’s higher education (HE) sector. The prevailing assumption had been that, as a Soviet society, Lithuania enjoyed a high level of education at the tertiary level. Yet, the facts of the matter speak differently; during the Soviet period, only about 10% of the general population went on to obtain HE qualifications.
The Disruptive Futures of Education—Post-COVID-19 Pandemic
Authors: Razak Dzulkifli Abdul 
Published: September 2021

AbstractThe year 2020 is mostly known to many as an inflection point. A metaphorical vision to look far ahead, with clarity, taking on the various “disruptions” that have been much touted, namely, the Fourth Industrial Revolution (4IR). Since its pronouncement, four years ago, during the 2016 World Economic Forum in Davos, the world of higher education has been inundated with demands to introduce the so-called ‘Education 4.0’.
Unsupervised event classification with graphs on classical and photonic quantum computers
Authors: Blance Andrew , Spannowsky Michael 
Published: September 2021

Abstract
Photonic Quantum Computers provide several benefits over the discrete qubit-based paradigm of quantum computing. By using the power of continuous-variable computing we build an anomaly detection model to use on searches for New Physics. Our model uses Gaussian Boson Sampling, a #P-hard problem and thus not efficiently accessible to classical devices. This is used to create feature vectors from graph data, a natural format for representing data of high-energy collision events. A simple K-means clustering algorithm is used to provide a baseline method of classification. We then present a novel method of anomaly detection, combining the use of Gaussian Boson Sampling and a quantum extension to K-means known as Q-means. This is found to give equivalent results compared to the classical clustering version while also reducing the $$ \mathcal{O} $$
O
complexity, with respect to the sample’s feature-vector length, from $$ \mathcal{O}(N) $$
O

N

to $$ \mathcal{O}\left(\log (N)\right) $$
O

log

N

.
Real-time gravitational replicas: low dimensional examples
Authors: Colin-Ellerin Sean , Dong Xi , Marolf Donald , Rangamani Mukund , Wang Zhencheng 
Published: September 2021

Abstract
We continue the study of real-time replica wormholes initiated in [1]. Previously, we had discussed the general principles and had outlined a variational principle for obtaining stationary points of the real-time gravitational path integral. In the current work we present several explicit examples in low-dimensional gravitational theories where the dynamics is amenable to analytic computation. We demonstrate the computation of Rényi entropies in the cases of JT gravity and for holographic two-dimensional CFTs (using the dual gravitational dynamics). In particular, we explain how to obtain the large central charge result for subregions comprising of disjoint intervals directly from the real-time path integral.
Himalayan Tectonic Belt: Morlet Wavelet Variation and Seismic Harmony
Authors: Xu Yebang , Burton Paul W. 
Published: September 2021

AbstractMorlet wavelet analysis is a method of studying the periodic spectrum of non-stationary physical signals and is applied to the Himalayan Tectonic Belt to explore whether there is any seismic periodicity, and to explore the possibility of harmony or commonality of properties among the seismic activities of different zones. The earthquake sequence during 1951–2016 with magnitudes M ≥ 6.0 is analysed. Wavelet non-periodicity for the Centre zone suggests a non-uniform spatial–temporal distribution of earthquake movement between plates which may relate with the rare great earthquakes, while the periodicities for the west and east zones may suggest the concurrence with the adjustment of the tectonic movement of the east- and west-end regions of the Himalayan Tectonic Belt relative to its central core. These three zones collectively form the Himalayan Tectonic Belt. This contains a periodicity of about five years of seismic activity that tests successfully with a 95% confidence statistic. Borrowing from the concept of musical harmony, this is the significant seismic harmonic which reflects the Belt’s pervasive tectonic stress and an overall harmony of continent–continent plate convergence. Morlet wavelet analysis also reveals the Himalayan Tectonic Belt and the Pamir–Hindu Kush Tectonic Zone to be engaged as a big new family: the Himalayan Tectonic Belt Plus. It is demonstrated that this new whole also has seismic harmony with the common property again being the 5-year periodicity. This indicates a unified structure of pervading active stress and seismic harmony permeating the overall seismicity.
Anwendungspraktische Limitationen bei der Aufklärung im Rahmen von Arzneimitteltherapien
Authors: Meyer Thomas , Steuer Melanie 
Published: September 2021

ZusammenfassungDer Erfolg einer Pharmakotherapie wird durch das Auftreten unerwünschter Arzneimittelwirkungen und die nur schwer vorhersehbaren Interaktionen zwischen mehreren Arzneimitteln bei Polypharmazie begrenzt. Bei Berücksichtigung der komplexen Wirkungsweise von Arzneimitteln einschließlich ihrer jeweils spezifischen Nebenwirkungsprofile werden an das ärztliche Aufklärungsgespräch mit Blick auf das Gebot einer patientengerechten Verständlichkeit hohe Anforderungen gestellt, insbesondere in Bezug auf eine ordnungsgemäße und vollständige Durchführung der Risiko- und Alternativaufklärung, aber auch hinsichtlich der Sicherungsaufklärung. Doch diese Anforderungen lassen sich praktisch wohl kaum jemals im medizinischen Alltag wirklich umsetzen. In diesem Artikel sollen deshalb anhand ausgewählter, aktueller Rechtsprechung die anwendungspraktischen Limitationen bei der Aufklärung vor der Einleitung und Überwachung einer Arzneimitteltherapie diskutiert werden. Im Besonderen wird auf bestehende Konfliktpotenziale zwischen dem Patientenrechtegesetz und dem sogenannten „Recht auf Nichtwissen“ hingewiesen.
Machining Digital Twin using real-time model-based simulations and lookahead function for closed loop machining control
Authors: Ward Rob , Sun Chao , Dominguez-Caballero Javier , Ojo Seun , Ayvar-Soberanis Sabino , Curtis David , Ozturk Erdem 
Published: September 2021

AbstractThe future of machining lies in the fully autonomous machine tool. New technologies must be developed that predict, sense and action intelligent decisions autonomously. Digital twins are one component on this journey and are already having significant impact in the manufacturing industries. Despite this, the implementation of machining Digital Twins has been slow due to the computational burden of simulating cutting forces online resulting in no commercially available Digital Twin that can automatically control the machining process in real time. Addressing this problem, this research presents a machining Digital Twin capable of real-time adaptive control of intelligent machining operations. The computational bottleneck of calculating cutter workpiece engagements online has been overcome using a novel method which combines a priori calculation with real-time tool centre point position data. For the first time, a novel online machine-induced residual stress control system is presented which integrates real-time model-based simulations with online feedback for closed loop residual stress control. Autonomous Digital Twin technologies presented also include chatter prediction and control and adaptive feed rate control. The proposed machining Digital Twin system has been implemented on a large-scale CNC machine tool designed for high-speed machining of aerostructure parts. Validation case studies have been conducted and are presented for each of the machining Digital Twin applications.
The KSBA compactification of the moduli space of $$D_{1,6}$$-polarized Enriques surfaces
Authors: Schaffler Luca 
Published: September 2021

AbstractWe describe a compactification by stable pairs (also known as KSBA compactification) of the 4-dimensional family of Enriques surfaces which arise as the $${\mathbb {Z}}_2^2$$

Z
2
2

-covers of the blow up of $${\mathbb {P}}^2$$

P

2

at three general points branched along a configuration of three pairs of lines. Up to a finite group action, we show that this compactification is isomorphic to the toric variety associated to the secondary polytope of the unit cube. We relate the KSBA compactification considered to the Baily–Borel compactification of the same family of Enriques surfaces. Part of the KSBA boundary has a toroidal behavior, another part is isomorphic to the Baily–Borel compactification, and what remains is a mixture of these two. We relate the stable pair compactification studied here with Looijenga’s semitoric compactifications.
Benefit of [18F]-FDG PET/CT for treatment-naïve nasopharyngeal carcinoma
Authors: Yang Shan-Shan , Wu Yi-Shan , Chen Wei-Chao , Zhang Jun , Xiao Su-Ming , Zhang Bao-Yu , Liu Zhi-Qiao , Chen En-Ni , Zhang Xu , OuYang Pu-Yun , Xie Fang-Yun 
Published: September 2021

Abstract
Background
To test the advantages of positron emission tomography and computed tomography (PET/CT) for diagnosing lymph nodes and staging nasopharyngeal carcinoma and to investigate its benefits for survival and treatment decisions.

Methods
The performance of PET/CT and magnetic resonance imaging (MRI) in diagnosis was compared based on 460 biopsied lymph nodes. Using the propensity matching method, survival differences of T3N1M0 patients with (n = 1093) and without (n = 1377) PET/CT were compared in diverse manners. A radiologic score model was developed and tested in a subset of T3N1M0 patients.

Results
PET/CT performed better than MRI with higher sensitivity, accuracy, and area under the receiver operating characteristic curve (96.7% vs. 88.5%, p < 0.001; 88.0% vs. 81.1%, p < 0.001; 0.863 vs. 0.796, p < 0.05) in diagnosing lymph nodes. Accordingly, MRI-staged T3N0-3M0 patients showed nondifferent survival rates, as they were the same T3N1M0 if staged by PET/CT. In addition, patients staged by PET/CT and MRI showed higher survival rates than those staged by MRI alone (p < 0.05), regardless of the Epstein-Barr virus DNA load. Interestingly, SUVmax-N, nodal necrosis, and extranodal extension were highly predictive of survival. The radiologic score model based on these factors performed well in risk stratification with a C-index of 0.72. Finally, induction chemotherapy showed an added benefit (p = 0.006) for the high-risk patients selected by the model but not for those without risk stratification (p = 0.78).

Conclusion
PET/CT showed advantages in staging nasopharyngeal carcinoma due to a more accurate diagnosis of lymph nodes and this contributed to a survival benefit. PET/CT combined with MRI provided prognostic factors that could identify high-risk patients and guide individualized treatment.
Entwicklung von Affiliation während der Psychotherapieausbildung
Authors: Thanbichler Eric , Evers Oliver , Möller Heidi , Taubner Svenja 
Published: September 2021

Zusammenfassung
Fragestellung
Die Studie untersuchte die Entwicklung von Affiliation bei psychotherapeutischen Ausbildungskandidat:innen in Bezug auf ihr therapeutisches Handeln, ihre Selbstwahrnehmung und ihre Wahrnehmung von Klient:innen. Zudem wurde der Einfluss von Bindungsrepräsentationen und Selbsterfahrung auf die Affiliation betrachtet.

Material und Methode
In einem naturalistischen Prä-Post-Design bewerteten Ausbildungskandidat:innen unterschiedlicher therapeutischer Orientierungen (n = 126) verschiedene Affiliationsdimensionen in schwierigen Therapiesituationen (Intrex Questionnaire Short Form) über den Abstand von 3 Jahren. Bindungsangst und Bindungsvermeidung wurden zu Beginn (Experiences in Close Relationships, ECR-RD), Länge und Zufriedenheit der Selbsterfahrung am Ende des Erhebungszeitraums erfasst. Die Zusammenhangsanalysen wurden in Mehrebenenmodellen realisiert.

Ergebnisse
Die Affiliation im eigenen therapeutischen Verhalten und in der Wahrnehmung des Klient:innenverhaltens zeigte Steigerungen kleiner Effektgröße, wobei Bindungsvermeidung eine geringere Affiliation im eigenen Verhalten voraussagte. Die selbstbezogene Affiliation nahm mit einer mittleren Effektgröße ab; hierbei war Bindungsangst mit einer niedrigeren Affiliation assoziiert. Die Selbsterfahrungsdauer wies einen negativen Zusammenhang mit der Wahrnehmung des Klient:innenverhaltens auf; dieser Effekt kehrte sich bei hoher Bindungsvermeidung um. Die Zufriedenheit mit Selbsterfahrung hatte keinen Einfluss auf die Affiliationsentwicklung.

Schlussfolgerung
Die interpersonelle und intrapsychische Affiliation von angehenden Psychotherapeut:innen ist z. T. durch Bindungsrepräsentationen geprägt, unterliegt aber Entwicklungsprozessen. Die Abnahme selbstbezogener Affiliation zeigt die Notwendigkeit für kompensatorische und ressourcenstärkende Maßnahmen in der Psychotherapieausbildung.
Coding of interceptive saccades in parietal cortex of macaque monkeys
Authors: Churan Jan , Kaminiarz Andre , Schwenk Jakob C. B. , Bremmer Frank 
Published: September 2021

AbstractThe oculomotor system can initiate remarkably accurate saccades towards moving targets (interceptive saccades) the processing of which is still under debate. The generation of these saccades requires the oculomotor centers to have information about the motion parameters of the target that then must be extrapolated to bridge the inherent processing delays. We investigated to what degree the information about motion of a saccade target is available in the lateral intra-parietal area (area LIP) of macaque monkeys for generation of accurate interceptive saccades. When a multi-layer neural network was trained based on neural discharges from area LIP around the time of saccades towards stationary targets, it was also able to predict the end points of saccades directed towards moving targets. This prediction, however, lagged behind the actual post-saccadic position of the moving target by ~ 80 ms when the whole neuronal sample of 105 neurons was used. We further found that single neurons differentially code for the motion of the target. Selecting neurons with the strongest representation of target motion reduced this lag to ~ 30 ms which represents the position of the moving target approximately at the onset of the interceptive saccade. We conclude that—similarly to recent findings from the Superior Colliculus (Goffart et al. J Neurophysiol 118(5):2890–2901)—there is a continuum of contributions of individual LIP neurons to the accuracy of interceptive saccades. A contribution of other gaze control centers (like the cerebellum or the frontal eye field) that further increase the saccadic accuracy is, however, likely.
Influence of the activation mode on long-term bond strength and endogenous enzymatic activity of dual-cure resin cements
Authors: Mazzitelli Claudia , Maravic Tatjana , Mancuso Edoardo , Josic Uros , Generali Luigi , Comba Allegra , Mazzoni Annalisa , Breschi Lorenzo 
Published: September 2021

Abstract
Objective
To investigate the long-term microtensile bond strength (µTBS), interfacial nanoleakage expression (NL), and adhesive stability of dual-cure resin cements with/out light activation to dentin.

Materials and methods
Composite overlays (N = 20) were luted to deep dentin surfaces with RelyX Ultimate (RXU, 3M) or Variolink EstheticDC (VAR, Ivoclar-Vivadent). A universal adhesive was used for bonding procedures (iBond universal, Heraeus Kulzer). The resin cements were either self-cured (SC; 1 h at 37 °C) or dual-cured (DC; 20s light-cure followed by 15 min self-cure at 37 °C). Specimens were submitted to µTBS immediately (T0) or after 1 year of laboratory storage (T12). The fracture pattern was evaluated using scanning electron microscopy (SEM). Data were statistically analyzed with two-way ANOVA/Tukey test. Further, the NL was quantified and analyzed (chi-square test) and in situ zymography was performed to evaluate the endogenous enzymatic activity within the hybrid layer (HL) at T0 and T12 (Mann–Whitney test). The significance level for all statistical tests was set at p = 0.05.

Results
DC resulted in higher bond strength and decreased fluorescence at the adhesive interface, irrespective of the material and the storage period (p < 0.05). Significantly lower bonding performances (p < 0.05) and higher endogenous enzymatic activity (p < 0.05) were observed within the HL at T12 compared to T0 in all tested groups.

Conclusions
Light-curing the dual-cure resin cements, more than the cement materials, accounted for good bonding performances and higher HL stability over time when used with a universal adhesive.

Clinical significance
The curing condition influences the bonding performances of dual-cure resin cements to dentin when used with a universal adhesive.
Medizinische Ereignisse auf Windenergieanlagen offshore – retrospektive Analyse der Behandlungsdaten 2017–2020
Authors: Warnecke Tobias , Neumann Dennis , Book Malte , Franz Rüdiger , Jacobsen Nils , Kleinhäntz Wolfgang , Warnking Eva , Overheu Daniel 
Published: September 2021

Zusammenfassung
Hintergrund
Insgesamt arbeiten täglich mehrere Tausend Menschen im Offshore-Bereich. Die Arbeit findet regelhaft unter beengten Bedingungen, in Höhen und Tiefen statt, woraus ein erhöhtes Gefahrenpotenzial mit spezifischen Verletzungen resultiert. Weiterhin müssen die Arbeiter in ihren mehrwöchigen Einsätzen allgemeinmedizinisch versorgt werden. Nach erfolgter Digitalisierung der medizinischen Einsatzdokumentation sollen nun die ersten Jahre ausgewertet und vor allem Art und Inzidenz der Notfälle analysiert werden.

Methode
4356 Datensätze aus dem Zeitraum Juni 2017 bis Dezember 2020 wurden im Rahmen der Versorgung und Einsatzdokumentation durch das eingesetzte Rettungsfachpersonal mittels digitalem Protokoll erfasst und nun anonymisiert retrospektiv ausgewertet.

Ergebnisse
Bei den definierten Diagnosegruppen waren am häufigsten die Infektionen (13,2 %) und Atemwegserkrankungen (8,4 %) sowie bei den Unfällen die Traumata der oberen (8,4 %) und unteren (4,6 %) Extremität. Entsprechend zählten 21,2 % der Einsätze zu den traumatologischen Notfällen, 71,1 % zu internistischen und 4,0 % zu sonstigen Erkrankungen. Die meisten Fälle wurden als geringfügige (61,2 %) oder ambulant behandelbare Störungen (23,4 %) eingestuft. Der nur bei vollständigen Datensätzen (n = 884) zu errechnende Schweregrad (Mainz Emergency Evaluation Score) lag im Mittel bei 24,1 ± 2,2 von 28 Punkten. Nur 1,9 % der Patienten wurden per Offshore-Rettungshubschrauber an Land verlegt, 4,0 % konnten mittels „crew transfer vessel“ transportiert werden.

Schlussfolgerung
Bei den meisten medizinischen Notfällen handelte es sich um minderschwere Ereignisse aus dem internistischen Spektrum mit geringfügiger Störung und ambulanter Behandlung. Bei den traumatologischen Notfällen sind Verletzungen an den Extremitäten führend. War eine Landverlegung erforderlich, geschah diese meist mittels „crew transfer vessel“ und nur zu einem Viertel der Fälle via Offshore-Rettungshubschrauber. Auch hier überwogen internistische Erkrankungen als Transportindikation.
High-resolution image-based simulation reveals membrane strain concentration on osteocyte processes caused by tethering elements
Authors: Yokoyama Yuka , Kameo Yoshitaka , Kamioka Hiroshi , Adachi Taiji 
Published: September 2021

AbstractOsteocytes are vital for regulating bone remodeling by sensing the flow-induced mechanical stimuli applied to their cell processes. In this mechanosensing mechanism, tethering elements (TEs) connecting the osteocyte process with the canalicular wall potentially amplify the strain on the osteocyte processes. The ultrastructure of the osteocyte processes and canaliculi can be visualized at a nanometer scale using high-resolution imaging via ultra-high voltage electron microscopy (UHVEM). Moreover, the irregular shapes of the osteocyte processes and the canaliculi, including the TEs in the canalicular space, should considerably influence the mechanical stimuli applied to the osteocytes. This study aims to characterize the roles of the ultrastructure of osteocyte processes and canaliculi in the mechanism of osteocyte mechanosensing. Thus, we constructed a high-resolution image-based model of an osteocyte process and a canaliculus using UHVEM tomography and investigated the distribution and magnitude of flow-induced local strain on the osteocyte process by performing fluid–structure interaction simulation. The analysis results reveal that local strain concentration in the osteocyte process was induced by a small number of TEs with high tension, which were inclined depending on the irregular shapes of osteocyte processes and canaliculi. Therefore, this study could provide meaningful insights into the effect of ultrastructure of osteocyte processes and canaliculi on the osteocyte mechanosensing mechanism.