bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simplifying Survivorship Care Planning: A Randomized Controlled Trial Comparing 3 Care Plan Delivery Approaches
Authors: Snyder Claire , Choi Youngjee , Blackford Amanda L , DeSanto Jennifer , Mayonado Nancy , Rall Susan , White Sharon , Bowie Janice , Cowall David E , Johnston Fabian , Joyner Robert L , Mischtschuk Joan , Peairs Kimberly S , Thorner Elissa , Tran Phuoc T , Wolff Antonio C , Smith Katherine C ,   the SSCP Stakeholder Advisory Board
Published: July 2021

Abstract

Background
Survivorship care plans seek to improve the transition to survivorship, but the required resources present implementation barriers. This randomized controlled trial aimed to identify the simplest, most effective approach for survivorship care planning.

Methods
Stage 1-3 breast, colorectal, and prostate cancer patients aged 21 years or older completing treatment were recruited from an urban-academic and rural-community cancer center. Participants were randomly assigned, stratified by recruitment site and cancer type 1:1:1 to a mailed plan, plan delivered during a 1-time transition visit, or plan delivered during a transition visit plus 6-month follow-up visit. Health service use data were collected from participants and medical records for 18 months. The primary outcome, receipt of all plan-recommended care, was compared across intervention arms using logistic regression adjusting for cancer type and recruitment site, with P less than .05 considered statistically significant.

Results
Of 378 participants randomly assigned, 159 (42.1%) were breast, 142 (37.6%) prostate, and 77 (20.4%) colorectal cancer survivors; 207 (54.8%) from the academic site and 171 (45.2%) from the community site; 316 were analyzable for the primary outcome. There was no difference across arms in the proportion of participants receiving all plan-recommended care: 45.2% mail, 50.5% 1-visit, 42.7% 2-visit (2-sided P = .60). Adherence by cancer type for mail, 1-visit, and 2-visit, respectively, was 52.2%, 53.3%, and 40.0% for breast cancer; 48.6%, 64.1%, and 57.1% for prostate cancer; and 23.8%, 19.0%, and 26.1% for colorectal cancer. There were no statistically significant interactions by recruitment site or cancer type.

Conclusions
This study did not find differences in receipt of recommended follow-up care by plan delivery approach. Feasibility and other factors may determine the best approach for survivorship care planning.
Glioblastoma Contains Topologically Distinct Proliferative and Metabolically Defined Subpopulations of Nestin- and Glut1-Expressing Cells
Authors: Prosniak Michael , Kenyon Lawrence C , Hooper D Craig 
Published: July 2021

Abstract
The difficulty in treatment of glioblastoma is a consequence of its natural infiltrative growth and the existence of a population of therapy-resistant glioma cells that contribute to growth and recurrence. To identify cells more likely to have these properties, we examined the expression in tumor specimens of several protein markers important for glioma progression including the intermediate filament protein, Nestin (NES), a glucose transporter (Glut1/SLC2A1), the glial lineage marker, glial fibrillary acidic protein, and the proliferative indicator, Ki-67. We also examined the expression of von Willebrand factor, a marker for endothelial cells as well as the macrophage/myeloid markers CD163 and CD15. Using a multicolor immunofluorescence and hematoxylin and eosin staining approach with archival formalin-fixed, paraffin embedded tissue from primary, recurrent, and autopsy IDH1 wildtype specimens combined with high-resolution tissue image analysis, we have identified highly proliferative NES(+)/Glut1(–) cells that are preferentially perivascular. In contrast, Glut1(+)/NES(–) cells are distant from blood vessels, show low proliferation, and are preferentially located at the borders of pseudopalisading necrosis. We hypothesize that Glut1(+)/NES(–) cells would be naturally resistant to conventional chemotherapy and radiation due to their low proliferative capacity and may act as a reservoir for tumor recurrence.
Strangulation of intraperitoneal kidney transplant by fallopian tube
Authors: Nawabi Atta , Nawabi Perwaiz , Mohammadian Babak , Jones Jill 
Published: July 2021

Abstract
Renal allograft strangulation is a rare complication following simultaneous kidney pancreas transplant, often causing graft loss. This case report represents the first documented case of a 35-year-old female who developed renal graft strangulation around the left fallopian tube. Our case outlines a new complication that contributes to graft loss concerning iliac fossa anatomy and variations in female patients, as well as surgical considerations that need to be made prior to transplantation. We recommend measurement of the grafted renal vessels within the iliac fossa and respective surroundings structures to allow for the ideal positioning of the grafted organ.
Ascending aorta replacement with concomitant coronary and peripheral artery bypass grafting
Authors: Jackson W Landon , Williams Charles D 
Published: July 2021

Abstract
Atherosclerosis of the aorta is a well-known risk factor for peri-operative complications in patients undergoing cardiac surgery. Coronary and peripheral artery bypass procedures can be challenging when the native aorta is not amenable to bypass grafting due to severe calcification. We describe the successful management of a patient who underwent ascending aorta replacement with concomitant three-vessel coronary artery bypass, bilateral aorto-axillary bypass and left axillary-to-carotid bypass.
For profit or strategic purpose? Chinese outbound energy investments and the international economic regime
Authors: Gong Xiaohan , Boute Anatole 
Published: July 2021

Abstract
Chinese foreign energy investments are facing increasing opposition based on concerns that they are made with an ulterior strategic motive. Some states have been seeking to block the access of Chinese companies to their market and, for existing investments, to international arbitration, by portraying them as instruments of the government. It is important for China’s participation in the international economic system that its energy companies are not automatically excluded because of suspicion of China’s motives, but are subject to a nuanced assessment in which national and international economic law has a role to play. To distinguish strategic from commercial projects, this article analyses the Chinese regulation of outbound energy investments based on international principles of economic governance. The objective is to identify channels of political interference with investment decisions, by focusing on regulatory approval, state guidance and corporate governance.
Has yield plasticity already been exploited by soybean breeding programmes in Argentina?
Authors: de Felipe Matías , Alvarez Prado Santiago 
Published: July 2021

AbstractThis study focuses on the impact of genetic improvement of seed yield plasticity in soybean (Glycine max L.) in high-yielding environments (between 4000 kg ha–1 and 7000 kg ha–1) of Central Argentina. The association between seed yield and its plasticity was analysed with (i) a historical collection of 148 genotypes released to the market between 1980 and 2013 and (ii) 165 currently available commercial genotypes. The impact on seed yield of soybean breeding programmes in Argentina reveals higher genetic progress of the lowest (1.7% year–1) rather than the highest yielding genotypes (0.9% year–1). At the same time, seed yield plasticity has been exploited indirectly. Increased seed yield plasticity over time contributed to a reduction in genotypic seed yield variability (P&lt;0.0001). Seed yield plasticity was related to seed yield in high-yielding environments (&gt;5500 kg ha–1). Plastic genotypes showed a positive correlation with the length of the seed-filling period (r=0.5), suggesting that a longer seed-filling period could be required to maximize seed yield plasticity under high-yielding environments. To increase productivity, clarifying the value of plasticity will aid genotype selection for target environments, as well as the development of high-yielding cultivars specifically adapted to high-yielding conditions.
Relationship Between Body Mass Index and Diagnosis of Obesity in the Military Health System Active Duty Population
Authors: Yang Daren , Beauvais Alexis , Forbes Whitney L , Beckman Darrick , Estes Jason , Martinez Craig , Wardian Jana 
Published: July 2021

ABSTRACT

Objective
The overall rate of obesity is rising in the USA; this is also reflected in the military population. It is important that providers appropriately diagnose obesity and discuss treatment options with their patients.
The purpose of this study was to investigate diagnosis of obesity compared to documented body mass index (BMI) in the military health system.

Methods
Institutional review board approval was obtained by the 59th Medical Wing (Lackland Air Force Base, Texas) as an exempt study. This study included active duty military service members aged 18-65 years who sought outpatient care at a military treatment facility from September 2013 to August 2018 with a weight within the range of 31.8-226.8 kg and height between 121.9 and 215.9 cm. Data were collected from the Clinical Data Repository vitals and M2 encounter data to determine the percentage of each sub-population with a diagnosis of obesity according to BMI (≥30 kg/m2) and International Classification of Diseases diagnosis codes.

Results
Using BMI, 19.2% of female and 26.8% of male service members can be diagnosed with obesity; however, only 42.2% and 35.1%, respectively, with a BMI ≥30 was diagnosed as such. This discrepancy was consistent among all service branches and BMI ranges.

Conclusion
This study demonstrates that obesity is underdiagnosed compared to BMI. This may result in insufficient resources being provided to patients to reduce weight. Further investigation is warranted to identify causes of underdiagnosis and potential barriers to diagnosis.
Invasive aspergillosis is a critical determinant of mortality in cirrhosis: a systematic review with meta-analysis
Authors: Verma Nipun , Singh Shreya , Syal Arshi , Pradhan Pranita , Singh Manvi , Singh Meenu 
Published: July 2021

Abstract

Invasive fungal infections pose a severe threat in unconventional immunocompromised hosts such as cirrhosis. Herein we review the impact of invasive aspergillosis (IA) on the prognosis of cirrhosis patients. An electronic search for full-text articles describing IA in cirrhosis was conducted and the disease outcomes and mortality (point-estimate and comparative risk) were pooled on random-effects meta-analysis. Of 4127 articles, 11 studies (9 with good/fair and 2 with poor quality) were included. IA was associated with high disease severity and multi-organ failures in cirrhosis. The pooled-mortality of IA was 81.8% (95% CI: 64.3–91.8, I2 = 59%, P &lt; 0.01). Estimate's-heterogeneity (I2) was explored through sub-groups, meta-regression, and influential diagnostics. Mortality estimates were higher among subgroups of acute-on-chronic liver failure (ACLF, 86.4%) and intensive care unit (ICU)-admitted patients (84.0%). The odds of mortality related to IA were 8.9 times higher than controls and much higher in ACLF (OR: 22.5) and ICU-admitted patients (OR: 36.4). The odds of mortality in IA were 4.1, 12.9, and 48.6 times higher than bacterial, no-fungal infections, and no-infection controls. There was no asymmetry in mortality estimates or odds ratios and mortality in IA was high irrespective of country of origin, site of infection, proven or probable category, and quality of study. Thus, IA is associated with very high mortality in cirrhosis patients, especially in ACLF and ICU-admitted patients. Intensive research is needed for the rapid diagnosis and treatment of IA in cirrhosis.

Lay summary
We report a high mortality rate of 81.8% in patients with liver cirrhosis and invasive aspergillosis. Higher odds (8.9 times) of death, especially in patients with ACLF or ICU admission were seen. Mortality was not affected by the country of study, site of infection, proven or probable nature of infection category, and quality of study.
High tide: a systematic search for ellipsoidal variables in ASAS-SN
Authors: Rowan D M , Stanek K Z , Jayasinghe T , Kochanek C S , Thompson Todd A , Shappee B J , Holoien T W -S , Prieto J L 
Published: July 2021

ABSTRACT
The majority of non-merging stellar mass black holes are discovered by observing high energy emission from accretion processes. Here, we pursue the large, but still mostly unstudied population of non-interacting black holes and neutron stars by searching for the tidally induced ellipsoidal variability of their stellar companions. We start from a sample of about 200 000 rotational variables, semiregular variables, and eclipsing binary stars from the All-Sky Automated Survey for Supernovae. We use a χ2 ratio test followed by visual inspection to identify 369 candidates for ellipsoidal variability. We also discuss how to combine the amplitude of the variability with mass and radius estimates for observed stars to calculate a minimum companion mass, identifying the most promising candidates for high mass companions.
SN2017jgh: a high-cadence complete shock cooling light curve of a SN IIb with the Kepler telescope
Authors: Armstrong P , Tucker B E , Rest A , Ridden-Harper R , Zenati Y , Piro A L , Hinton S , Lidman C , Margheim S , Narayan G , Shaya E , Garnavich P , Kasen D , Villar V , Zenteno A , Arcavi I , Drout M , Foley R J , Wheeler J , Anais J , Campillay A , Coulter D , Dimitriadis G , Jones D , Kilpatrick C D , Muñoz-Elgueta N , Rojas-Bravo C , Vargas-González J , Bulger J , Chambers K , Huber M , Lowe T , Magnier E , Shappee B J , Smartt S , Smith K W , Barclay T , Barentsen G , Dotson J , Gully-Santiago M , Hedges C , Howell S , Cody A , Auchettl K , Bódi A , Bognár Zs , Brimacombe J , Brown P , Cseh B , Galbany L , Hiramatsu D , Holoien T W-S , Howell D A , Jha S W , Könyves-Tóth R , Kriskovics L , McCully C , Milne P , Muñoz J , Pan Y , Pál A , Sai H , Sárneczky K , Smith N , Sódor Á , Szabó R , Szakáts R , Valenti S , Vinkó J , Wang X , Zhang K , Zsidi G 
Published: July 2021

ABSTRACT
SN 2017jgh is a type IIb supernova discovered by Pan-STARRS during the C16/C17 campaigns of the Kepler/K2 mission. Here, we present the Kepler/K2 and ground based observations of SN 2017jgh, which captured the shock cooling of the progenitor shock breakout with an unprecedented cadence. This event presents a unique opportunity to investigate the progenitors of stripped envelope supernovae. By fitting analytical models to the SN 2017jgh light curve, we find that the progenitor of SN 2017jgh was likely a yellow supergiant with an envelope radius of $\sim 50{\!-\!}290\, {\rm R}_{\odot }$, and an envelope mass of $\sim 0{\!-\!}1.7\, {\rm M}_{\odot }$. SN 2017jgh likely had a shock velocity of ∼7500−10 300 km s−1. Additionally, we use the light curve of SN 2017jgh to investigate how early observations of the rise contribute to constraints on progenitor models. Fitting just the ground based observations, we find an envelope radius of $\sim 50{\!-\!}330\, {\rm R}_{\odot }$, an envelope mass of $\sim 0.3{\!-\!}1.7\, {\rm M}_{\odot }$ and a shock velocity of ∼9000−15 000 km s−1. Without the rise, the explosion time cannot be well constrained that leads to a systematic offset in the velocity parameter and larger uncertainties in the mass and radius. Therefore, it is likely that progenitor property estimates through these models may have larger systematic uncertainties than previously calculated.
Rapid expansion of red giant stars during core helium flash by waves propagation to the envelope and implications to exoplanets
Authors: Bear Ealeal , Merlov Ariel , Arad Yarden , Soker Noam 
Published: July 2021

ABSTRACT
We assume that the strong convection during core helium flash of low mass red giant branch (RBG) stars excite waves that propagate to the envelope, and find that the energy that these waves deposit in the envelope causes envelope expansion and brightening. We base our assumption and the estimate of the waves’ energy on studies that explored such a process due to the vigorous core convection of massive stars just before they experience a core collapse supernova explosion. Using the stellar evolutionary code mesa, we find that the waves’ energy causes an expansion within few years by tens to hundreds solar radii. Despite the large brightening, we expect the increase in radius and luminosity to substantially enhance mass-loss rate and dust formation. The dust shifts the star to become much redder (to the infrared), and the star might actually become fainter in the visible. The overall appearance is of a faint red transient event that lasts for months to few years. We suggest that in some cases envelope expansion might lead stars that are about to leave the RGB to engulf exoplanets. The extended envelope has a smaller binding energy to a degree that allows planets of several Jupiter masses or more and brown dwarfs to survive the common envelope evolution. We suggest this scenario to account for the planet orbiting the white dwarf (WD) WD 1856+534 (TIC 267574918) and for the WD–brown dwarf binary system ZTFJ003855.0+203025.5.
Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast
Authors: Yague-Sanz Carlo , Duval Maxime , Larochelle Marc , Bachand François 
Published: July 2021

AbstractTranscription termination of protein-coding genes in eukaryotic cells usually relies on a tight coordination between the cleavage and polyadenylation of the pre-mRNA, and 5′-3′ degradation of the downstream nascent transcript. Here we investigated the contribution of the essential fission yeast endonuclease Pac1, a homolog of human Drosha that cleaves hairpin RNA structures, in triggering polyadenylation-independent transcription termination. Using ChIP-sequencing in Pac1-deficient cells, we found that Pac1 triggers transcription termination at snRNA and snoRNA genes as well as at specific protein-coding genes. Notably, we found that Pac1-dependent premature termination occurred at two genes encoding conserved transmembrane transporters whose expression were strongly repressed by Pac1. Analysis by genome editing indicated that a stem-loop structure in the nascent transcript directs Pac1-mediated cleavage and that the regions upstream and downstream of the Pac1 cleavage site in the targeted mRNAs were stabilized by mutation of nuclear 3′-5′ and 5′-3′ exonucleases, respectively. Our findings unveil a premature transcription termination pathway that uncouples co-transcriptional RNA cleavage from polyadenylation, triggering rapid nuclear RNA degradation.
Diaphragmatic hernia during treatment of lung cancer harboring an EGFR mutation
Authors: Konno-Yamamoto Aya , Narumoto Osamu , Yamamoto Shota , Yamaguchi Miho , Motoyoshi Makoto , Inoue Yuta , Fukami Takeshi , Tamura Atsuhisa , Matsui Hirotoshi 
Published: July 2021

ABSTRACT
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are a first-line treatment for patients with nonsmall-cell lung cancer harboring EGFR mutations. We report a 65-year-old Japanese woman with nonsmall-cell lung cancer taking an EGFR-TKI who visited the emergency department with acute nausea and vomiting. Imaging studies demonstrated an incarcerated diaphragmatic hernia. Urgent diagnostic surgery revealed a gap in the diaphragm acting as a hernial orifice, where a metastatic tumor was detected. We consider that regression of the diaphragmatic metastasis by EGFR-TKI therapy resulted in perforation of the diaphragm, causing the diaphragmatic hernia. Gastrointestinal adverse events, e.g. nausea, vomiting and diarrhea, are common during EGFR-TKI treatment. However, this case suggests that in patients with diaphragmatic metastasis, we should consider the rare possibility of diaphragmatic perforation and a subsequent hernia.
Probabilistic projections of future warming and climate sensitivity trajectories
Authors: Goodwin Philip 
Published: July 2021

Abstract
Projections of future global mean surface warming for a given forcing scenario remain uncertain, largely due to uncertainty in the climate sensitivity. The ensemble of Earth system models from the Climate Model Intercomparison Project phase 6 (CMIP6) represents the dominant tools for projecting future global warming. However, the distribution of climate sensitivities within the CMIP6 ensemble is not representative of recent independent probabilistic estimates, and the ensemble contains significant variation in simulated historic surface warming outside agreement with observational datasets. Here, a Bayesian approach is used to infer joint probabilistic projections of future surface warming and climate sensitivity for shared socio-economic pathway (SSP) scenarios. The projections use an efficient climate model ensemble filtered and weighted to encapsulate observational uncertainty in historic warming and ocean heat content anomalies. The probabilistic projection of climate sensitivity produces a best estimate of 2.9°C, and 5th–95th percentile range of 1.5–4.6°C, in line with previous estimates using multiple lines of evidence. The joint projection of surface warming over the period 2030–40 has a 50% or greater probability of exceeding 1.5°C above preindustrial for all SSPs considered: 119, 126, 245, 370 and 585. Average warming by the period 2050–60 has a &gt;50% chance of exceeding 2°C for SSPs 245, 370 and 585. These results imply that global warming is no longer likely to remain under 1.5°C, even with drastic and immediate mitigation, and highlight the importance of urgent action to avoid exceeding 2°C warming.
11Feminisms
Authors: Thurman Deborah 
Published: July 2021

Abstract
This chapter reviews a selection of new work in the field of feminist critical and cultural theory published in the year 2020. The chapter consists of five sections: 1. Introduction, which addresses the context of the Covid-19 pandemic for the reception and application of feminist thought; 2. Feminist Technologies, which reviews Legacy Russell’s Glitch Feminism: A Manifesto and Catherine D’Ignazio and Lauren F. Klein’s Data Feminism; 3. Archival Bodies, which reviews Cait McKinney’s Information Activism: A Queer History of Lesbian Media Technologies and Samantha Pinto’s Infamous Bodies: Early Black Women’s Celebrity and the Afterlives of Rights; 4. From Resilience to Revolution, which reviews Angela McRobbie’s Feminism and the Politics of Resilience: Essays on Gender, Media and the End of Welfare and Revolutionary Feminisms: Conversations on Collective Action and Radical Thought, edited by Brenna Bhandar and Rafeef Ziadah; 5. Conclusion, which highlights three generative preoccupations within contemporary feminist thought.