bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coagulation derangement and risk factors for valve thrombosis following transcatheter aortic valve implantation
Authors: Patterson Tiffany , Hurrell Harriet , Lee Jack , Esposito Giulia , Dutta Utkarsh , Grapsa Julia , Aroney Nicholas , Ahmed-Jushuf Fiyyaz , Allen Christopher , Rajani Ronak , Preston Rebecca , Young Christopher , Lucchese Gianluca , Parmar Kiran , Hunt Beverley , Prendergast Bernard D , Redwood Simon R 
Published: June 2021

AimsDurability of transcatheter aortic valve implantation (TAVI) is key to its expansion. We sought to identify incidence of valve thrombosis and predictors of valve thrombosis in our single centre with associated coagulation testing pre-TAVI and post-TAVI.Methods and resultsThis single-centre observational study comprised patients undergoing transfemoral TAVI discussed in the Heart Team meeting . Patients were followed up with echocardiography at 120 days to identify incidence of elevated transvalvular gradient and multivariable analysis was performed to identify factors associated with an increased odds of developing valve thrombosis. In addition, 11 patients underwent baseline, day 1 and day 120 post-TAVI coagulation testing. Between August 2017 and August 2019, 437 consecutive patients underwent transfemoral TAVI. Of these patients, 207/437 (47.4%) had 3-month follow-up echo data available and were analysed. Of these patients, 26/207 (12.6%) had elevated transvalvular gradients. These patients tended to be younger (80±14 vs 83±6 years; p=0.047) with a lower ejection fraction (49±13 vs 54%±11%; p=0.021), with a greater proportion of the population experiencing atrial fibrillation (14/21, 54% vs 68/181, 38%; p=0.067). Following multivariable analysis, there remained a trend towards higher eccentricity index associated with elevated gradients. Baseline (pre-TAVI) elevation of thrombin antithrombin levels (56±63; reference range 1.0–4.1 ng/L) and PF 1+2 (791±632; reference range 69–229 ng/mL) normalised at 120 days post-TAVIConclusionThis study demonstrated that in the cohort of patients undergoing transfemoral TAVI in our centre: younger age, poor ejection fraction, atrial fibrillation and increased baseline eccentricity of the aortic valve annulus were present to a greater extent in patients exhibiting elevated transvalvular gradients at 3-month follow-up. Further work is required to delineate the extent of coagulation derangement and confirm predictors of thrombosis.
Vascular comorbidities worsen prognosis of patients with heart failure hospitalised with COVID-19
Authors: Mok Jacob , Malpartida Juan Carlos , O'Dell Kimberly , Davis Joshua , Gao Cuilan , Manyam Harish 
Published: June 2021

BackgroundPrior diagnosis of heart failure (HF) is associated with increased length of hospital stay (LOS) and mortality from COVID-19. Associations between substance use, venous thromboembolism (VTE) or peripheral arterial disease (PAD) and its effects on LOS or mortality in patients with HF hospitalised with COVID-19 remain unknown.ObjectiveThis study identified risk factors associated with poor in-hospital outcomes among patients with HF hospitalised with COVID-19.MethodsCase–control study was conducted of patients with prior diagnosis of HF hospitalised with COVID-19 at an academic tertiary care centre from 1 January 2020 to 28 February 2021. Patients with HF hospitalised with COVID-19 with risk factors were compared with those without risk factors for clinical characteristics, LOS and mortality. Multivariate regression was conducted to identify multiple predictors of increased LOS and in-hospital mortality in patients with HF hospitalised with COVID-19.ResultsTotal of 211 patients with HF were hospitalised with COVID-19. Women had longer LOS than men (9 days vs 7 days; p<0.001). Compared with patients without PAD or ischaemic stroke, patients with PAD or ischaemic stroke had longer LOS (7 days vs 9 days; p=0.012 and 7 days vs 11 days, p<0.001, respectively). Older patients (aged 65 and above) had increased in-hospital mortality compared with younger patients (adjusted OR: 1.04; 95% CI 1.00 to 1.07; p=0.036). Prior diagnosis of VTE increased mortality more than threefold in patients with HF hospitalised with COVID-19 (adjusted OR: 3.33; 95% CI 1.29 to 8.43; p=0.011).ConclusionVascular diseases increase LOS and mortality in patients with HF hospitalised with COVID-19.
Breathlessness across generations: results from the RHINESSA generation study
Authors: Ekström Magnus , Johannessen Ane , Abramson Michael J , Benediktsdottir Bryndis , Franklin Karl , Gislason Thorarinn , Gómez Real Francisco , Holm Mathias , Janson Christer , Jogi Rain , Lowe Adrian , Malinovschi Andrei , Martínez-Moratalla Jesús , Oudin Anna , Sánchez-Ramos José Luis , Schlünssen Vivi , Svanes Cecilie 
Published: June 2021

BackgroundBreathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations.MethodsWe analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry. Data were analysed using multivariable logistic regression accounting for clustering within centres and between siblings.ResultsA total of 1720 parents (mean age at assessment 36 years, 55% mothers) and 2476 offspring (mean 30 years, 55% daughters) were included. Breathlessness was reported by 809 (32.7%) parents and 363 (14.7%) offspring. Factors independently associated with breathlessness in parents and offspring included obesity, current smoking, asthma, depression, lower lung function and female sex. After adjusting for potential confounders, parents with breathlessness were more likely to have offspring with breathlessness, adjusted OR 1.8 (95% CI 1.1 to 2.9). The association was not modified by sex of the parent or offspring.ConclusionParents with breathlessness were more likely to have children who developed breathlessness, after adjusting for asthma, lung function, obesity, smoking, depression and female sex in both generations. The hereditary components of breathlessness need to be further explored.
Lotty – The loop-tree duality automation
Authors: Torres Bobadilla William J. 
Published: June 2021

AbstractElaborating on the novel formulation of the loop-tree duality, we introduce the Mathematica package Lotty that automates the latter at multi-loop level. By studying the features of Lotty and recalling former studies, we discuss that the representation of any multi-loop amplitude can be brought in a form, at integrand level, that only displays physical information, which we refer to as the causal representation of multi-loop Feynman integrands. In order to elucidate the role of Lotty in this automation, we recall results obtained for the calculation of the dual representation of integrands up-to four loops. Likewise, within Lotty framework, we provide support to the all-loop causal representation recently conjectured by the same author. The numerical stability of the integrands generated by Lotty is studied in two-loop planar and non-planar topologies, where a numerical integration is performed and compared with known results.
The hubble tension as a hint of leptogenesis and neutrino mass generation
Authors: Escudero Miguel , Witte Samuel J. 
Published: June 2021

AbstractThe majoron, a neutrinophilic pseudo-Goldstone boson conventionally arising in the context of neutrino mass models, can damp neutrino free-streaming and inject additional energy density into neutrinos prior to recombination. The combination of these effects for an eV-scale mass majoron has been shown to ameliorate the outstanding$$H_0$$H0tension, however only if one introduces additional dark radiation at the level of$$\Delta N_{\mathrm{eff}} \sim 0.5$$ΔNeff∼0.5. We show here that models of low-scale leptogenesis can naturally source this dark radiation by generating a primordial population of majorons from the decays of GeV-scale sterile neutrinos in the early Universe. Using a posterior predictive distribution conditioned on Planck2018+BAO data, we show that the value of$$H_0$$H0observed by the SH$$_0$$0ES collaboration is expected to occur at the level of$$\sim 10\%$$∼10%in the primordial majoron cosmology (to be compared with$$\sim 0.1\%$$∼0.1%in the case of$$\Lambda $$ΛCDM). This insight provides an intriguing connection between the neutrino mass mechanism, the baryon asymmetry of the Universe, and the discrepant measurements of$$H_0$$H0.
On the choice of the collapse operator in cosmological Continuous Spontaneous Localisation (CSL) theories
Authors: Martin Jérôme , Vennin Vincent 
Published: June 2021

AbstractThe Continuous Spontaneous Localisation (CSL) theory in the cosmological context is subject to uncertainties related to the choice of the collapse operator. In this paper, we constrain its form based on generic arguments. We show that, if the collapse operator is even in the field variables, it is unable to induce the collapse of the wavefunction. Instead, if it is odd, we find that only linear operators are such that the outcomes are distributed according to Gaussian statistics, as required by measurements of the cosmic microwave background. We discuss implications of these results for previously proposed collapse operators. We conclude that the cosmological CSL collapse operator should be linear in the field variables.
Revisiting the concept of activation in supercooled liquids
Authors: Baity-Jesi Marco , Biroli Giulio , Reichman David R. 
Published: June 2021

AbstractIn this work, we revisit the description of dynamics based on the concepts of metabasins and activation in mildly supercooled liquids via the analysis of the dynamics of a paradigmatic glass former between its onset temperature $$T_{\mathrm{o}}$$

T
o

and mode-coupling temperature $$T_{\mathrm{c}}$$

T
c

. First, we provide measures that demonstrate that the onset of glassiness is indeed connected to the landscape, and that metabasin waiting time distributions are so broad that the system can remain stuck in a metabasin for times that exceed $$\tau _{\alpha }$$

τ
α

by orders of magnitude. We then reanalyze the transitions between metabasins, providing several indications that the standard picture of activated dynamics in terms of traps does not hold in this regime. Instead, we propose that here activation is principally driven by entropic instead of energetic barriers. In particular, we illustrate that activation is not controlled by the hopping of high energetic barriers and should more properly be interpreted as the entropic selection of nearly barrierless but rare pathways connecting metabasins on the landscape.
Climate-induced hysteresis of the tropical forest in a fire-enabled Earth system model
Authors: Drüke Markus , Bloh Werner von , Sakschewski Boris , Wunderling Nico , Petri Stefan , Cardoso Manoel , Barbosa Henrique M. J. , Thonicke Kirsten 
Published: June 2021

AbstractTropical rainforests are recognized as one of the terrestrial tipping elements which could have profound impacts on the global climate, once their vegetation has transitioned into savanna or grassland states. While several studies investigated the savannization of, e.g., the Amazon rainforest, few studies considered the influence of fire. Fire is expected to potentially shift the savanna-forest boundary and hence impact the dynamical equilibrium between these two possible vegetation states under changing climate. To investigate the climate-induced hysteresis in pan-tropical forests and the impact of fire under future climate conditions, we employed the Earth system model CM2Mc, which is biophysically coupled to the fire-enabled state-of-the-art dynamic global vegetation model LPJmL. We conducted several simulation experiments where atmospheric CO$$_2$$

2

concentrations increased (impact phase) and decreased from the new state (recovery phase), each with and without enabling wildfires. We find a hysteresis of the biomass and vegetation cover in tropical forest systems, with a strong regional heterogeneity. After biomass loss along increasing atmospheric CO$$_2$$

2

concentrations and accompanied mean surface temperature increase of about 4 $$^\circ $$

∘

C (impact phase), the system does not recover completely into its original state on its return path, even though atmospheric CO$$_2$$

2

concentrations return to their original state. While not detecting large-scale tipping points, our results show a climate-induced hysteresis in tropical forest and lagged responses in forest recovery after the climate has returned to its original state. Wildfires slightly widen the climate-induced hysteresis in tropical forests and lead to a lagged response in forest recovery by ca. 30 years.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate
Authors: Goncalves Judith , Moog Sophie , Morin Aurélie , Gentric Géraldine , Müller Sebastian , Morrell Alexander P. , Kluckova Katarina , Stewart Theodora J. , Andoniadou Cynthia L. , Lussey-Lepoutre Charlotte , Bénit Paule , Thakker Alpesh , Vettore Lisa , Roberts Jennie , Rodriguez Raphaël , Mechta-Grigoriou Fatima , Gimenez-Roqueplo Anne-Paule , Letouzé Eric , Tennant Daniel A. , Favier Judith 
Published: June 2021

Abstract

Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit are associated with increased risk of metastasis. Here we generated an Sdhd knockout chromaffin cell line and compared it with Sdhb-deficient cells. Both cell types exhibited similar SDH loss of function, metabolic adaptation, and succinate accumulation. In contrast, Sdhb−/− cells showed hallmarks of mesenchymal transition associated with increased DNA hypermethylation and a stronger pseudo-hypoxic phenotype compared with Sdhd−/− cells. Loss of SDHB specifically led to increased oxidative stress associated with dysregulated iron and copper homeostasis in the absence of NRF2 activation. High-dose ascorbate exacerbated the increase in mitochondrial reactive oxygen species, leading to cell death in Sdhb−/− cells. These data establish a mechanism linking oxidative stress to iron homeostasis that specifically occurs in Sdhb-deficient cells and may promote metastasis. They also highlight high-dose ascorbate as a promising therapeutic strategy for SDHB-related cancers.

Significance:
Loss of different succinate dehydrogenase subunits can lead to different cell and tumor phenotypes, linking stronger 2-OG–dependent dioxygenases inhibition, iron overload, and ROS accumulation following SDHB mutation.
“Rescue” of Nonparticipants in Colorectal Cancer Screening: A Randomized Controlled Trial of Three Noninvasive Test Options
Authors: Young Graeme Paul , Chen Gang , Wilson Carlene J. , McGrane Ellen , Hughes-Barton Donna Lee-Ann , Flight Ingrid Helen K. , Symonds Erin Leigh 
Published: June 2021

Abstract

Few studies have directly targeted nonparticipants in colorectal cancer screening to identify effective engagement strategies. We undertook a randomized controlled trial that targeted nonparticipants in a previous trial of average-risk subjects which compared participation rates for mailed invitations offering a fecal test, a blood test or a choice of either. Nonparticipants (n = 899) were randomized to be offered a kit containing a fecal immunochemical test (FIT), directions on how to arrange a blood DNA test, or the option of doing either. Screening participation was assessed 12 weeks after the offer. To assess the cognitive and attitudinal variables related to participation and invitee choice, invitees were surveyed after 12 weeks, and associations were investigated using multinomial logistic regression. Participation rates were similar between groups (P = 0.88): 12.0% for FIT (35/292), 13.3% for the blood test (39/293), and 13.4% for choice (39/290). Within the choice group, participation was significantly higher with FIT (9.7%, 28/290) compared with the blood test (3.8%, 11/290, P = 0.005). The only variable significantly associated with participation was socioeconomic status when offered FIT, and age when offered choice but there was none when offered the blood test. Survey respondents indicated that convenience, time-saving, comfort, and familiarity were major influences on participation. There was no clear advantage between a fecal test, blood test, or choice of test although, when given a choice, the fecal test was preferred. Differences in variables associated with participation according to invitation strategy warrant consideration when deciding upon an invitation strategy for screening nonparticipants.

Prevention Relevance:
This trial of screening for those at average risk for colorectal cancer targeted past fecal-test nonparticipants and compared participation rates for mailed invitations offering a fecal test, blood test, or choice of either. Although there was no clear advantage between strategies, factors associated with participation differed between each strategy.
Cumulative Serum Uric Acid and Its Time Course Are Associated With Risk of Myocardial Infarction and All‐Cause Mortality
Authors: Tian Xue , Wang Anxin , Wu Shouling , Zuo Yingting , Chen Shuohua , Zhang Licheng , Mo Dapeng , Luo Yanxia 
Published: June 2021

Background
Serum uric acid (SUA) has been demonstrated as a risk factor for myocardial infarction (MI) and all‐cause mortality; however, the impact of cumulative SUA (cumSUA) remains unclear. We aimed to investigate the association of cumSUA with MI risk and all‐cause mortality, and to further explore the effects of SUA accumulation time course.

Methods and Results
The study enrolled 53 463 participants without a history of MI, and these participants underwent 3 examinations during 2006 to 2010. cumSUA from baseline to the third examination was calculated, multiplying mean values between consecutive examinations by time intervals between visits. Cox models estimated hazard ratios (HRs) and 95% CIs of MI and all‐cause mortality for cumSUA quartiles, hyperuricemia exposure duration, and SUA accumulation time course. During a median follow‐up of 7.04 years, 476 incident MIs and 2692 deaths occurred. In the fully adjusted model, a higher MI risk was observed in the highest cumSUA quartile (HR, 1.48; 95% CI, 1.10–1.99), in participants with longer hyperuricemia exposure duration (HR, 1.71; 95% CI, 1.06–2.73), and in participants with cumSUA≥median and a negative slope (HR, 1.58; 95% CI, 1.18–2.11). Similar associations persisted for all‐cause mortality.

Conclusions
The risk of MI and all‐cause mortality increased with higher cumSUA and was affected by the SUA accumulation time course. Early SUA accumulation contributed more to MI risk and all‐cause mortality than later SUA accumulation with the same overall cumulative exposure, emphasizing the importance of optimal SUA control early in life.
Measures of Left Ventricular Diastolic Function and Cardiorespiratory Fitness According to Glucose Metabolism Status: The Maastricht Study
Authors: Veugen Marja G. J. , Linssen Pauline B. C. , Henry Ronald M. A. , Koster Annemarie , Kroon Abraham A. , Stehouwer Coen D. A. , Brunner‐La Rocca Hans‐Peter 
Published: June 2021

Background
This cross‐sectional study evaluated associations between structural and functional measures of left ventricular diastolic function and cardiorespiratory fitness (CRF) in a well‐characterized population‐based cohort stratified according to glucose metabolism status.

Methods and Results

Six hundred seventy‐two participants from The Maastricht Study (mean±SD age, 61±9 years; 17.4% prediabetes and 25.4% type 2 diabetes mellitus) underwent both echocardiography to determine left atrial volume index, left ventricular mass index, maximum tricuspid flow regurgitation, average e′ and E/e′ ratio; and submaximal cycle ergometer test to determine CRF as maximum power output per kilogram body mass. Associations were examined with linear regression adjusted for cardiovascular risk and lifestyle factors, and interaction terms. After adjustment, in normal glucose metabolism but not (pre)diabetes, higher left atrial volume index (per 1 mL/m
2
), left ventricular mass index (per 1 g/m
2.7
), maximum tricuspid regurgitation flow (per 1 m/s) were associated with higher CRF (maximum power output per kilogram body mass; β in normal glucose metabolism 0.015 [0.008–0.023],
P
interaction
(pre)diabetes <0.10; 0.007 [−0.001 to 0.015],
P
interaction
type 2 diabetes mellitus <0.10; 0.129 [0.011–0.246],
P
interaction
>0.10; for left atrial volume index, left ventricular mass index, maximum tricuspid regurgitation flow, respectively). Furthermore, after adjustment, in all individuals, higher average E/e′ ratio (per unit), but not average e′, was associated with lower CRF (normal glucose metabolism −0.044 [−0.071 to −0.016]),
P
interaction
>0.10).

Conclusions
In this population‐based study, structural and functional measures of left ventricular diastolic function were independently differentially associated with CRF over the strata of glucose metabolism status. This suggests that deteriorating left ventricular diastolic function, although of small effect, may contribute to the pathophysiological process of impaired CRF in the general population. Moreover, the differential effects in these structural measures may be the consequence of cardiac structural adaptation to effectively increase CRF in normal glucose metabolism, which is absent in (pre)diabetes.
The Aesthetics of Doom: Nature, Science, and Art in Henry Adams's Dynamic Theory of History
Authors: Sommer Robert F. 
Published: June 2021

Abstract
The Education of Henry Adams and The Degradation of the Democratic Dogma reject the anthropocentric view of scientific history and its implied theme of human progress. In Darwin, Haeckel, the Curies, and other scientists Adams found a model for the study of history within the fabric of nature. Adams's “dynamic theory of history” argues for a wholistic view of history and nature.
Pterocarpus wood identification by independent and complementary analysis of DART-TOFMS, microscopic anatomy, and fluorescence spectrometry
Authors: Price Erin R. , Miles-Bunch Isabella A. , Gasson Peter E. , Lancaster Cady A. 
Published: June 2021

Abstract
Attention to illegal logging practices and demanding policies in transnational timber trade have driven the need for species-level identification of timber. Historically wood has been identified to genus level using microscopy and anatomical characteristics, however, new chemometric and imaging methods have been developed to increase the speed and precision of timber identification. This study approaches species identification using a combination of complementary methods: Direct Analysis in Real Time–Time-of-Flight Mass Spectrometry (DART-TOFMS), wood anatomy, and fluorescence spectroscopy. Seven commercially and environmentally significant species in Pterocarpus, including P. erinaceus (CITES Appendix II), P. santalinus (CITES Appendix II), P. tinctorius (CITES Appendix II), P. indicus, P. macrocarpus, P. dalbergioides, and P. soyauxii were studied. It was found that DART-TOFMS paired with discriminant analysis of principal components (PCA) could classify species with an accuracy of 95–100%, while anatomy in combination with PCA applied to fluorescence spectra could be used to classify CITES Appendix II species. In the absence of access to DART-TOFMS, a combination of wood anatomy and fluorescence spectrometry can permit more accurate identification than anatomy alone.