bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a new type of drug supplement on epileptic seizure induced by pilocarpine and the amount of nitric oxide produced by vascular epithelial cells as a trigger for migraine headache
Authors: Bayat Azam , Khalkhali Aref , Mahjoub Ali Reza 
Published: June 2021

Abstract
The present study aims to investigate the effect of a new type of dietary supplement on epileptic seizure induced by pilocarpine and the amount of nitric oxide produced by vascular epithelial cells as a trigger for migraine headache. New healthy and live drug supplement were synthesized by a green route. This organic biomaterial was named NBS. Concentrations of the drug supplement were prepared by dissolving dry powder in saline phosphate-buffered. In recent years, NO has been suggested as one of the factors involved in migraine headache. Nitrite concentration was also measured as an indicator of nitric oxide production by Griess method. In order to induce seizure, on 25th day after birth, each puppy was injected into control and treatment groups with healthy and live diet in 150 mg/ kg subcutaneously. The behavior of each rat was recorded by a digital camera and two observers. It can be stated that this supplement causes a significant reduction in the level of 5% concentration of nitric oxide compared to the control group (p≤0.05). Also, 15 mg/ kg of the Dapsone increases the duration of seizure from medication to onset of seizure, while, using the new NBS healthy and live diet significantly increases this time compared to the Dapsone recipient group. The new healthy and nutritious drug can significantly reduce the incidence of migraine headaches and would prevent the onset of a seizure.
Sales Forecasting Model Based on BP Neural Network Optimized by Improved Immune Genetic Algorithm
Authors: Cao Kunyu , Chen Yongdang , Song Xinxin , Liu Shan 
Published: June 2021

Abstract
A new sales forecasting model based on an Improved Immune Genetic Algorithm (IIGA), IIGA that optimizes the BPNN (IIGA-BP) has been proposed. The IIGA presents a new way of population initialization, a regulatory mechanism of antibody concentration, and a design method of adaptive crossover operator and mutation operator, which effectively improved the convergence ability and optimization anility of IIGA. And IIGA can optimize the BPNN’s initial weights and threshold and improve the randomness of network parameters as well as the drawbacks that lead to output instability of BPNN and easiness into local minimum value. It taking the past records of sales figures of a certain steel enterprise as an example, utilizing the Matlab to construct the BP neural network, Immune Genetic Algorithm that optimizes the BPNN (IGA-BP), IGA-BP neural network, and IIGA-BP neural network prediction models for simulation and comparative analysis. The experiment demonstrates that IIGA-BP neural network prediction model possessing a higher prediction accuracy and more stable prediction effects.
Computational Modeling of Aldose Reductase Inhibitory Activity of Flavonoids Derivatives for Diabetic Complications Treatment
Authors: Díaz-Amador Roberto , Cañizares-Carmenate Yudith , Taboada-Crispi Alberto , Castillo-Garit Juan A. 
Published: June 2021

Background:
Diabetes mellitus is a chronic metabolic disease that constitutes a risk factor
for patients infected by COVID-19. Aldose reductase (ALR2) is an enzyme that catalyzes the formation
of sorbitol in the metabolism of glucose via polyols in diabetic patients and leads to a group
of diabetic complications: cataracts, retinopathies, neuropathies, and nephropathies.

Introduction:
Inhibitors of this enzyme are therapeutic targets for the prophylaxis and treatment of
these conditions. The aim of this work was to identify flavonoids isolated from medicinal plants,
fruits, and vegetables as potential inhibitors of ALR2.

Methods:
In this study, using the MATLAB numerical computation system and the molecular descriptors
implemented in the DRAGON software, a regression tree was developed, with an R2 of
0.953 and adequate parameters for its fit.

Results:
he model was validated to take into account internal and external validation procedures.
Besides, the applicability domain was determined to guarantee the reliability of the predictions. Due
to its good predictive power (R2
ext = 0.949), the model was used to predict the inhibition of ALR2 by
flavonoids reported in dietary sources. The most promising flavonoids are Myricetin and Tricin
(pIC50predicted = 7.296), which are within the application domain and meet drug-like properties for
oral administration.

Conclusion:
Finally, we can conclude that the proposed tools are useful for the rapid and economical
identification of flavonoid-based potential drug candidates against ALR2 in diabetic complications.
State-of-the-Art and Projected Developments of Nanofiber Filter Material
for Face Mask Against COVID-19
Authors: Patel Gayatri , Patel Priya , Yadav Bindu Kumari 
Published: June 2021

Background:
The Covid-19 epidemic was declared a pandemic by the World Health Organization
in March 2020. It is difficult to foresee the future length and severity; it may extend to weeks,
months, or even years to deplete the energy and resources of the health care facilities and the providers
as there is marginal to no pharmacological medication available to treat the Covid-19. Unless an effective
pharmacological treatment such as medicines and vaccines is developed and released publicly,
wearing protective face masks and protecting personal health and hygiene is merely a choice to avoid
the Covid-19 spread. This review summarizes the background knowledge on the Covid-19 disease and
currently available face masks for highly infectious disease primary prevention. According to recent
studies of Covid-19 prevention, diagnosis, and treatment, nanotechnologists have provided a revolutionary
approach that involves both pharmacological and non-pharmacological steps, one of which is
the use of nanofibers in facemasks and respirators.

Method:
Various researches carried out in the field of nanomask and patented reports based on the
application of nanomask were reviewed.

Summary:
The most recent developments of nanofibers, including research publications, patents and
commercial products in Covid-19 prevention, are extensively reviewed from scientific literature and
appropriately represented in this study.
MicroRNA (miRNA) Differential Expression and Exposure to Crude-Oil- Related Compounds
Authors: Vargas Gabriela Coronel 
Published: June 2021

:
This review summarizes studies on miRNA differential regulation related to exposure to
crude oil and 20 different crude oil chemicals, such as hydrocarbons, sulphur, nitrogen, and metalcontaining
compounds. It may be interesting to explore the possibility of using early post-transcriptional
regulators as a potential novel exposure biomarker.

:
Crude oil has been defined as a highly complex mixture of solids, liquids, and gases. Given the toxicological
properties of the petroleum components, its extraction and elaboration processes represent
high-risk activities for the environment and human health, especially when accidental spills occur.
The effects on human health of short-term exposure to petroleum are well known, but chronic
exposure effects may variate depending on the exposure type (i.e., work, clean-up activities, or
nearby residence).

:
As only two studies are focused on miRNA differential expression after crude-oil exposure, this review
will also analyse the bibliography concerning different crude-oil or Petroleum-Related Compounds
(PRC) exposure in Animalia L. kingdom and how it is related to differential miRNA transcript
levels. Papers include in vitro, animal, and human studies across the world.

:
A list of 10 miRNAs (miR-142-5p, miR-126-3p, miR-24-3p, miR-451a, miR-16-5p, miR-28-5p,
let-7b-5p, miR-320b, miR-27a-3p and miR-346) was created based on bibliography analysis and
hypothesised as a possible “footprint” for crude-oil exposure. miRNA differential regulation can be
considered a Big-Data related challenge, so different statistical programs and bioinformatics tools
were used to have a better understanding of the biological significate of the most interesting data.
CANCER, FERTILITY, AND PSYCHOLOGICAL DISTRESS
Authors: Kesić Vesna 
Published: June 2021

The number of young women treated for cancer who want to give birth is increasing, due to postponing pregnancy for older age. On the other hand, the disease is more often diagnosed in the early stage, when conservative treatment is much more successful, even in gynecological cancer. Most young women diagnosed with cancer can expect to live for decades after treatment, which makes many life issues, such as future fertility, increasingly important. This has led to the separation of Oncofertility as a new field in oncology, which includes all procedures for the treatment of malignant disease with the aim of preserving fertility, but without compromising the oncological outcome. And while the problem of fertility may not be a priority at the time of diagnosis, over time it becomes more important. Infertility resulting from cancer treatment has a major impact on quality of life. The turmoil experienced by women who are simultaneously faced with cancer and possible loss of fertility leave emotional consequences, especially if the localization of the disease directly affects the reproductive organs. Coping not just with medical issues, but with two psychological traumas at the same time increases susceptibility to distress. Helping to preserve the quality of life and the psychological aspect of caring for patients with malignant diseases who want to preserve the possibility of childbirth should become an indispensable part of treatment. Recognizing and managing negative emotions in cancer patients is a priority that aims to improve their quality of life.
Sistema de recomendación de programas universitarios para estudiantes de educación media basado en Deep Learning
Authors: Orozco-Cacique Johanna Alexandra , Moreno-Barbosa Andres Darío 
Published: June 2021

Los estudiantes que van a culminar la educación media y se enfrentan a la selección de programas académicos, usualmente usan buscadores web, información de programas y asesorías o pruebas vocacionales. Sin embargo, estas alternativas tienen limitaciones, porque no tienen en cuenta las características sociodemográficas del estudiante ni su desempeño académico o no pueden guiar adecuadamente a todos los estudiantes. Esta propuesta apoya la toma de decisiones de este grupo poblacional con un Sistema de Recomendación que produce recomendaciones basadas en variables sociodemográficas y datos académicos históricos de estudiantes de pregrado. Además, se compara el desempeño de un modelo de Filtrado Colaborativo clásico y Deep Learning.
Lessons Learned: Challenges When Conducting Interview-Based Research in Auditing and Methods of Coping
Authors: Dodgson Mary Kate , Trotman Andrew J. 
Published: June 2021

SUMMARY
Interview-based research is growing in prominence in auditing, yet many researchers are self-trained in this method, leading the novice interview researcher to encounter a number of roadblocks along the way. The overarching goal of our study is to add to the methodological resources available on the interview method by providing a compilation of challenges that novice interview researchers have experienced, along with suggested methods to cope with these challenges (i.e., how to overcome these challenges, what to do differently, and advice on navigating the interview method). With this new perspective, our paper serves as a resource to prospective interview-based researchers so they can enter the field better informed about possible roadblocks they might encounter along the way and methods to cope with these challenges. In turn, we hope to contribute to the production of more insightful and efficient interview-based research.
Information Processing Costs and Firms' Investment Efficiency: An Examination of Channels of the XBRL Effect
Authors: Feng Cecilia (Qian) , Kim Chansog (Francis) 
Published: June 2021

ABSTRACT
We examine the channels through which a reduction in information processing costs improves firm-level investment efficiency. We do so by exploiting the SEC's eXtensible Business Reporting Language (XBRL) mandate. We provide empirical evidence suggesting potential channels. Specifically, we find that, while the use of standardized official elements facilitates investment efficiency, the use of customized extension elements hinders it. In addition, we show that firms with Big 4 auditors experience less improvement in investment efficiency. We also investigate ex post investment performance and find that firms' return on assets and Tobin's q increase following XBRL adoption, suggesting improvements in the effectiveness of investments. Furthermore, we extend this line of research to investments in human capital. Notably, we show that labor investment efficiency is significantly improved in the post-XBRL era. This finding adds another dimension to the growing knowledge about the impact of accounting information on firm-level investment decisions.
JEL Classifications: G30; M40; M41; M48.
In vitro Streptococcus mutans adhesion and biofilm formation on different esthetic orthodontic archwires
Authors: Oliveira Deise C. , Thomson Joshua J. , Alhabeil Jamal A. , Toma Jonathan M. , Plecha Sarah C. , Pacheco Rafael R. , Cuevas-Suárez Carlos E. , Piva Evandro , Lund Rafael Guerra 
Published: June 2021

ABSTRACT

Objectives
To evaluate the ability of different esthetic archwires to retain oral biofilms in vitro.

Materials and Methods
Seven different brands of coated orthodontic archwires were tested: two epoxy coated, two polytetrafluoroethylene coated, two rhodium coated, and one silver plus polymer coated. Conventional uncoated metallic archwires were used as controls. Streptococus mutans adherence to archwires was quantified by colony count following 24 hours of biolfilm growth, and total wire-associated biofilm was measured using a crystal violet staining assay. For both tests, two conditions were used: 0% sucrose and 3% sucrose. For statistical analysis, P &lt; .05 was considered as statistically significant.

Results
For S. mutans colony forming units per biofilm, there were no statistically significant differences among the various archwires (P = .795 for 0% sucrose; P = .905 for 3% sucrose). Regarding total biofilm formed on archwires in the 3% sucrose condition, there were statistically significant differences in crystal violet staining only for the comparison between Niti Micro Dental White and Copper Ni-Ti wires (P &lt; .05).

Conclusions
The clinical use of esthetic-coated orthodontic wires may be considered to have similar risks as uncoated archwires for biofilm retention.
The Ability of Dental Practitioners to Light-Cure Simulated Restorations
Authors: Kojic DD , El-Mowafy O , Price R , El-Badrawy W 
Published: June 2021

SUMMARY

Objectives:
To determine the ability of dental professionals to deliver a radiant exposure of at least six J/cm2 in 10 seconds to simulated restorations.

Methods and Materials:
The study initially examined 113 light-emitting-diode (LED) light polymerization units (LPUs) used in dental offices to determine if they could deliver at least 6 J/cm2 radiant exposure (RE) in 10s. This assessment was completed by using a laboratory-grade light measuring device (checkMARC, BlueLight Analytics, Halifax, NS, Canada). The participating dental professionals whose LPUs could deliver 6 J/cm2 then used their own LPU to light-cure simulated anterior and posterior restorations in the MARC Patient Simulator (BlueLight Analytics). They then received specific instructions and were retested using the same LPUs. Data were statistically analyzed with a series of one-way analysis of variance (ANOVA), two-way ANOVA, paired-samples t-tests, Fisher post hoc multiple comparison tests, and McNemar tests with a preset alpha of 0.05 (SPSS Inc).

Results:
Ten (8.8%) LPUs could not deliver the required RE to the checkMARC in 10s and were eliminated from the study. For the anterior restoration, most dental practitioners (87.3%) could deliver at least 6 J/cm2 before instructions. After receiving additional light-curing instructions, only two (1.9%) participants were unable to deliver 6 J/cm2 to the anterior location. At the posterior location, only 55.3% (57) participants could deliver at least 6 J/cm2 before the instructions. After receiving these instructions, an additional 32 participants delivered at least 6 J/cm2. Overall, after receiving instructions on how to use the LPU correctly, the participants improved the amount of RE they delivered to anterior and posterior restorations by 22.5% and 30%, respectively.

Conclusion:
This study revealed that at the baseline, 44.7% of participating dental professionals failed to deliver 6 J/cm2 in 10s to the posterior simulated restoration when using their own LPU.
Pelaksanaan Fidusia Pada Bank Perkreditan Rakyat Ulatidana Rahayu yang Tidak Mendaftarkan Jaminan Secara Online
Authors: Arinata Thema Komang Andhika Yuna 
Published: June 2021

A fiduciary guarantee is a guarantee that binds movable and immovable property on this matter which does not allow the mortgage to be imposed, in accordance with the provisions of article 1 paragraph 2 of the Fiduciary Law that one can be burdened with fiduciary objects, one of which is immovable property which cannot be encumbered by mortgage . Banks have businesses in the form of providing credit. Credit is a loan from a bank in the form of a sum of money to the borrower accompanied by the surrender of collateral. The problem that occurs is the people's credit banks whose fiduciary guarantees are not registered, this happens because the banks are still based on trust in the debtor. The research method used is research conducted directly based on real events or also called empirical research. Empirical research was conducted directly from relevant parties, namely the People's Credit Bank Ulatidana Rahayu. The study results show the additional fees charged to the customer in registering fiduciary guarantees are quite high. Therefore the bank does not register fiduciary and is still based on the principle of trust. In connection with the non-registration of fiduciary guarantees, this is contrary to the principle of publicity and the executing ability of fiduciary guarantees no longer exists, so that when there is a default on the debtor, the Rural Credit Bank can not execute the guarante
Jaminan fidusia adalah jaminan yang mengikat barang bergerak dan barang tidak bergerak yang mengenai hal tersebut tidak memungkinkan dikenakan hak tanggungan, sesuai dengan ketentuan pasal 1 ayat 2 Undang-Undang Fidusia bahwa yang dapat dibebani fidusia salah satunya adalah benda tidak bergerak yang tidak dapat dibebani hak tanggungan. Perbankan memiliki usaha dalam bentuk memberikan kredit. Kredit adalah memberikan pinjaman oleh bank berupa sejumlah uang kepada pihak peminjam yang disertai penyerahan jaminan. Permasalahan yang terjadi adalah pihak bank perkreditan rakyat yang jaminan fidusianya tidak dilakukan pendaftaran, hal ini terjadi karena pihak bank masih berdasarkan kepercayaan terhadap debitur. Metode penelitian yang digunakan adalah penelitian yang dilakukan langsung berdasarkan kejadian nyata atau disebut juga dengan penelitian empiris. Penelitian empiris dilakukan secara langsung yang berasal dari pihak-pihak terkait yaitu pihak Bank Perkreditan Rakyat Ulatidana Rahayu. Hasil studi menunjukan biaya tambahan yang dikenakan pada pihak nasabah dalam pendaftaran jaminan fidusia cukup tinggi. Oleh karena itu pihak bank tidak mendaftarkan fidusia dan masih berdasarkan asas kepercayaan. Berkaitan dengan tidak didaftarkannya jaminan fidusia, hal ini bertentangan dengan asas publisitas dan kemampuan eksekutorial jaminan fidusia tidak ada lagi, sehingga ketika terjadi wanprestasi terhadap debitur maka Bank Perkreditan Rakyat tidak dapat melakukan eksekusi jaminan
Akibat Hukum Jual Beli Hak Atas Tanah Yang Belum Bersertipikat di Kantor Pertanahan Kabupaten Buleleng
Authors: Birehina Thomas Alexander 
Published: June 2021

Transfer of land ownership through buying and selling is done by surrendering his land as an object in the form of a certificate. This certificate is used as evidence that states the owner of the rights to his land that will be traded to the buyer. In practice, there is still land for sale in the field that does not yet have a certificate. The purpose of this research is to find out how the procedure of buying and selling land rights that have not been certified as well as the legal consequences of buying and selling land rights that are not yet certified. Empirical juridical research is a type of research in this paper. From the results of the study, the procedure that must be carried out first is by making a purchase agreement before a Notary to secure the interests of both parties, then the land is registered through a conversion at the Land Office for certificate issuance, so that the sale and purchase can be processed before the PPAT to be able to registered at the Land Office so that it is processed behind the name on behalf of the buyer. The legal consequences if the sale and purchase of land that has not been certified is not legal according to the law, unless first done through conversion at the Land Office and preceded by the making of the purchase agreement before the Notary. So that the seller's rights shift to the buyer.
Pengalihan kepemilikan tanah melalui jual beli dilakukan dengan menyerahkan tanahnya sebagai obyek dalam bentuk sertipikat. Sertipikat ini dijadikan alat bukti yang menyatakan pemilik dari hak atas tanahnya yang akan diperjualbelikan kepada pihak pembeli. Pada prakteknya dilapangan masih ada tanah yang diperjualbelikan tersebut belum memiliki sertipikat. Tujuan dalam penelitian ini untuk mengetahui bagaimana prosedur jual beli hak atas tanah yang belum bersertipikat serta akibat hukum jual beli hak atas tanah yang belum bersertipikat. Penelitian yuridis empiris menjadi jenis penelitian dalam penulisan ini. Dari hasil penelitian, prosedur yang harus dilakukan terlebih dahulu adalah dengan pembuatan perikatan jual beli dihadapan Notaris untuk mengamankan kepentingan kedua belah pihak, kemudian tanahnya di daftarkan melalui konversi di Kantor Pertanahan untuk diterbitkan sertipikat, dengan begitu barulah dapat diproses akta jual beli dihadapan PPAT untuk dapat didaftarkan di Kantor Pertanahan agar diproses balik nama atas nama pembeli. Akibat hukum bilamana jual beli tanah yang belum bersertipikat tersebut dilakukan belum sah menurut hukum, kecuali terlebih dahulu dilakukan melalui konversi di Kantor Pertanahan dan didahului pembuatan perikatan jual beli dihadapan Notaris. Sehingga haknya penjual beralih kepada pembeli.