bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dioscorea zingiberensis ameliorates diabetic nephropathy by inhibiting NLRP3 inflammasome and curbing the expression of p66Shc in high-fat diet/streptozotocin-induced diabetic mice
Authors: Ren Chaoxing , Zhou Xiaowei , Bao Xiaowen , Zhang Jie , Tang Jun , Zhu Zhiming , Zhang Nan , Bai Yu , Xi Youli , Zhang Qi , Ma Bo 
Published: March 2021

Abstract

Objectives
Diabetic nephropathy (DN) is a severe diabetic complication. Dioscorea zingiberensis (DZ) possesses excellent pharmacological properties with lower toxicity. The purpose of this study was to investigate the efficacy and mechanism of DZ in DN.

Methods
DN was established by the high-fat diet combining intraperitoneal injection of streptozotocin in mice. The DZ (125 and 250 mg/kg/day) were intragastrical administered for 8 consecutive weeks. After treatment, blood, urine and kidney tissue were collected for biological detection, renal morphology, fibrosis and molecular mechanism research, respectively.

Key findings
This study has shown that DZ significantly ameliorated kidney hypertrophy, renal structural damage and abnormal function of the kidney indicators (creatinine, urinary protein and blood urea nitrogen). Further molecular mechanism data suggested that the NLRP3/Cleaved-caspase-1 signal pathway was remarkably activated in DN, and DZ treatment reversed these changes, which indicated that it effectively attenuated inflammatory response caused by hyperglycaemia. In addition, DN inhibits hyperglycaemia-induced activation of oxidative stress by suppressing the expression of p66Shc proteins.

Conclusions
DZ could efficiently suppress oxidative stress and inflammatory responses to postpone the development of DN, and its mechanism might be related to inhibition of NLRP3 and p66Shc activities. Thus, DZ could be developed into a new therapeutic agent for DN.
2MASX J00423991 + 3017515: an offset active galactic nucleus in an interacting system
Authors: Hogg J Drew , Blecha Laura , Reynolds Christopher S , Smith Krista Lynne , Winter Lisa M 
Published: March 2021

ABSTRACT
We present a spectroscopic and imaging study of an abnormal active galactic nucleus (AGN), 2MASX J00423991 + 3017515. This AGN is newly identified in the hard X-rays by the Swift BAT All-Sky survey and found in an edge-on disc galaxy interacting with a nearby companion. Here, we analyse the first optical spectra obtained for this system (taken in 2011 and 2016), high-resolution imaging taken with the Hubble Space Telescope and Chandra X-ray Observatory, and 1 imaging with the Very Large Array. Two unique properties are revealed: the peaks of the broad Balmer emission lines (associated with gas orbiting very near the supermassive black hole) are blueshifted from the corresponding narrow line emission and host galaxy absorption by 1540 km s−1, and the AGN is spatially displaced from the apparent centre of its host galaxy by 3.8 kpc. We explore several scenarios to explain these features, along with other anomalies, and propose that 2MASX J00423991 + 3017515 may be an AGN with an unusually strong wind residing in a uniquely configured major merger, or that it is an AGN recoiling from either a gravitational ‘slingshot’ in a three-body interaction or from a kick due to the asymmetric emission of gravitational waves following the coalescence of two progenitor supermassive black holes.
Rapid formation of super-Earths around low-mass stars
Authors: Zawadzki Brianna , Carrera Daniel , Ford Eric B 
Published: March 2021

ABSTRACT
NASA’s TESS mission is expected to discover hundreds of M dwarf planets. However, few studies focus on how planets form around low-mass stars. We aim to better characterize the formation process of M dwarf planets to fill this gap and aid in the interpretation of TESS results. We use ten sets of N-body planet formation simulations that vary in whether a gas disc is present, initial range of embryo semimajor axes, and initial solid surface density profile. Each simulation begins with 147 equal-mass embryos around a 0.2 solar mass star and runs for 100 Myr. We find that planets form rapidly, with most collisions occurring within the first 1 Myr. The presence of a gas disc reduces the final number of planets relative to a gas-free environment and causes planets to migrate inward. We find that roughly a quarter of planetary systems experience their final giant impact inside the gas disc, suggesting that some super-Earths may be able to reaccrete an extended gaseous envelope after their final giant impact, though these may be affected by additional processes such as photoevaporation. In addition, we find that the final distribution of planets does not retain a memory of the slope of the initial surface density profile, regardless of whether or not a gas disc is present. Thus, our results suggest that present-day observations are unlikely to provide sufficient information to accurately reverse-engineer the initial distribution of solids.
A self-lensing binary massive black hole interpretation of quasi-periodic eruptions
Authors: Ingram Adam , Motta Sara E , Aigrain Suzanne , Karastergiou Aris 
Published: March 2021

ABSTRACT
Binary supermassive black hole (SMBH) systems result from galaxy mergers, and will eventually coalesce due to gravitational wave (GW) emission if the binary separation can be reduced to ≲0.1 pc by other mechanisms. Here, we explore a gravitational self-lensing binary SMBH model for the sharp (duration ∼1 h), quasi-regular X-ray flares – dubbed quasi-periodic eruptions – recently observed from two low-mass active galactic nuclei: GSN 069 and RX J1301.9+2747. In our model, the binary is observed ∼edge-on, such that each SMBH gravitationally lenses light from the accretion disc surrounding the other SMBH twice per orbital period. The model can reproduce the flare spacings if the current eccentricity of RX J1301.9+2747 is ϵ0 ≳ 0.16, implying a merger within ∼1000 yr. However, we cannot reproduce the observed flare profiles with our current calculations. Model flares with the correct amplitude are ∼2/5 the observed duration, and model flares with the correct duration are ∼2/5 the observed amplitude. Our modelling yields three distinct behaviours of self-lensing binary systems that can be searched for in current and future X-ray and optical time-domain surveys: (i) periodic lensing flares, (ii) partial eclipses (caused by occultation of the background mini-disc by the foreground mini-disc), and (iii) partial eclipses with a very sharp in-eclipse lensing flare. Discovery of such features would constitute very strong evidence for the presence of a supermassive binary, and monitoring of the flare spacings will provide a measurement of periastron precession.
Lyman continuum leakage from low-mass galaxies with M⋆ &lt; 108 M⊙
Authors: Izotov Y I , Worseck G , Schaerer D , Guseva N G , Chisholm J , Thuan T X , Fricke K J , Verhamme A 
Published: March 2021

ABSTRACT
We present observations with the Cosmic Origins Spectrograph onboard the Hubble Space Telescope of nine low-mass star-forming galaxies at redshifts, z, in the range 0.3179–0.4524, with stellar masses $M_\star \, \lt $ 108 M⊙ and very high specific star-formation rates sSFR ∼150–630 Gyr−1, aiming to study the dependence of leaking Lyman continuum (LyC) emission on stellar mass and some other characteristics of the galaxy. We detect LyC emission in four out of nine galaxies with escape fractions, fesc(LyC), in the range of 11–35 per cent, and establish upper limits for fesc(LyC) in the remaining five galaxies. We observe a narrow Ly α emission line with two peaks in seven galaxies and likely more complex Ly α profiles in the two remaining galaxies. The velocity separation between the peaks Vsep varies in the range from ∼229 to ∼512 km s−1. Our additional data on low-mass galaxies confirm and strengthen the tight anticorrelation between fesc(LyC) and Vsep found for previous low-redshift galaxy samples with higher stellar masses. Vsep remains the best indirect indicator of LyC leakage. It is better than O32 on which fesc(LyC) depends weakly, with a large scatter. Finally, contrary to expectations, we find no increase of fesc(LyC) with decreasing galaxy stellar mass M⋆.
Detecting and analysing geomorphological structures in images of comet 67P/Churyumov–Gerasimenko using Fourier transform
Authors: Ruzicka Birko-Katarina , Schröter Matthias , Pack Andreas , Boehnhardt Hermann 
Published: March 2021

ABSTRACT
We present a method for automatized detection and analysis of quasi-periodic lineament structures from images at pixel precision. The method exploits properties of the images’ frequency domain found by using the Fourier transform. We developed this method with the goal of detecting lineament structures in an image of the Hathor cliff of comet 67P/Churyumov–Gerasimenko, which are caused by layerings and furrows in the nucleus material. Using our method, we determined the orientation and wavelength range of these structures. The detected layering edges have similar orientations and spatial separations of 9–20 m, and are ubiquitous throughout the image. We suggest that the layerings are a global feature of the comet nucleus that provide information about formation and evolution of comet 67P. The furrows are non-uniformly distributed throughout the image. Their orientation is broadly parallel to the direction of the local gravity vector at the Hathor cliff, with spacings similar to those of the layering structures. The furrows are interpreted as signatures of local down-slope movement of cliff material. We demonstrate that the developed method is broadly applicable to the detection and analysis of various kinds of quasi-periodic structures like geological layering, folding and faulting, and texture analysis in general. In order to facilitate the application of our method, this paper is accompanied by a demo program written in matlab.
Health Agency and Perfectionism: The Case of Perinatal Health Inequalities
Authors: Ismaili M’hamdi Hafez , de Beaufort Inez 
Published: March 2021

Abstract
Poor pregnancy outcomes and inequalities in these outcomes remain a major challenge, even in prosperous societies that have high-quality health care and public health policy in place. In this article, we propose that justice demands the improvement of what we call the ‘health agency’ of parents-to-be as part of a response to these poor outcomes. We take health agency to have three aspects: (i) the capacity to form health-goals one has reason to value, (ii) the control one perceives to have over achieving those health-goals and (iii) the freedom(s) one has to achieve those health-goals. We will moreover argue that this demand of justice can be best based on a perfectionist rather than neutralist method of justification. Subsequently, we will argue that perfectionist policy may be paternalistic but not wrongfully paternalistic. This leads us to conclude that perfectionism should be adopted to inform and justify public health policy that is aimed at improving health agency in general and counteracting poor pregnancy outcomes and inequalities in perinatal health outcomes in particular.
Host-interactor screens of Phytophthora infestans RXLR proteins reveal vesicle trafficking as a major effector-targeted process
Authors: Petre Benjamin , Contreras Mauricio P , Bozkurt Tolga O , Schattat Martin H , Sklenar Jan , Schornack Sebastian , Abd-El-Haliem Ahmed , Castells-Graells Roger , Lozano-Durán Rosa , Dagdas Yasin F , Menke Frank L H , Jones Alexandra M E , Vossen Jack H , Robatzek Silke , Kamoun Sophien , Win Joe 
Published: March 2021

Abstract
Pathogens modulate plant cell structure and function by secreting effectors into host tissues. Effectors typically function by associating with host molecules and modulating their activities. This study aimed to identify the host processes targeted by the RXLR class of host-translocated effectors of the potato blight pathogen Phytophthora infestans. To this end, we performed an in planta protein–protein interaction screen by transiently expressing P. infestans RXLR effectors in Nicotiana benthamiana leaves followed by coimmunoprecipitation and liquid chromatography-tandem mass spectrometry. This screen generated an effector–host protein interactome matrix of 59 P. infestans RXLR effectors x 586 N. benthamiana proteins. Classification of the host interactors into putative functional categories revealed over 35 biological processes possibly targeted by P. infestans. We further characterized the PexRD12/31 family of RXLR-WY effectors, which associate and colocalize with components of the vesicle trafficking machinery. One member of this family, PexRD31, increased the number of FYVE positive vesicles in N. benthamiana cells. FYVE positive vesicles also accumulated in leaf cells near P. infestans hyphae, indicating that the pathogen may enhance endosomal trafficking during infection. This interactome dataset will serve as a useful resource for functional studies of P. infestans effectors and of effector-targeted host processes.
Reasons and Defeasible Reasoning
Authors: Brunero John 
Published: March 2021

AbstractAccording to the Reasoning View, a normative reason to φ is a premise in a pattern of sound reasoning leading to the conclusion to φ. But how should the Reasoning View account for reasons that are outweighed? One very promising proposal is to appeal to defeasible reasoning. On this proposal, when a reason is outweighed, the associated pattern of sound reasoning is defeated. Both Jonathan Way and Sam Asarnow have recently developed this idea in different ways. I argue that this appeal to defeasible reasoning faces a challenge, since reasons can be both outweighed and disabled. Way's view generates good predictions about outweighed reasons, but not about disabled reasons. Asarnow's view generates good predictions about disabled reasons, but not about outweighed reasons. We want a version of the Reasoning View that can generate good predictions about both. I present a version of the Reasoning View that can meet the challenge.
Will the demands by the covid-19 pandemic increase the intent to quit the profession of long-term care managers? A repeated cross-sectional study in Germany
Authors: Pförtner Timo-Kolja , Pfaff Holger , Hower Kira Isabel 
Published: March 2021

Abstract
The Corona pandemic poses major demands for long-term care, which might have impacted the intention to quit the profession among managers of long-term care facilities. We used cross-sectional data of an online survey of long-term care managers from outpatient and inpatient nursing and palliative care facilities surveyed in April 2020 (survey cycle one; n = 532) and between December 2020 and January 2021 (survey cycle two; n = 301). The results show a significant association between the perceived pandemic-specific and general demands and the intention to leave the profession. This association was significantly stronger for general demands in survey cycle two compared with survey cycle one. The results highlight the pandemic’s immediate impact on long-term care. In view of the increasing number of people in need of care and the already existing scarcity of specialized nursing staff, the results highlight the need for initiatives to ensure the provision of long-term care, also and especially in such times of crisis.
Inscriptions and Ways of Owning Books among the Sisters of Syon Abbey
Authors: King Julia 
Published: March 2021

Abstract
This article discusses the phenomenon of personal inscriptions in manuscripts and printed books associated with the sisters of Syon Abbey (founded 1415), the sole English Birgittine house. It argues that personal inscriptions reveal the Syon sisters’ complex ownership-like relationships with their books, and that the sisters were able to demonstrate both their individual and communal devotional identity through their interaction with each other and their books. In the first section, the article defines ‘ownership’ in its legal context and discusses it in relationship to ‘use’. The second section closely reads the Syon legislative documents to discuss the sisters’ conceptualizations of book ownership within the bounds of their order. The third section discusses the practice of inscription, using evidence from extant Syon manuscripts and early printed books. The fourth section brings these contexts together to discuss two cases of hybrid book ownership: the functional ownership developed through repeated use of the Syon processionals, and the collective individual ownership of multiple copies of printed books. The article presents a new way of understanding inscriptions and their potential for community building and individuation at Syon Abbey and contributes to our understanding of women’s reading experiences and ownership practices in England at the turn of the sixteenth century and the late-medieval period as a whole.
Medication adherence in older people with rheumatoid arthritis is lower according to electronic monitoring than according to pill count
Authors: Hartman Linda , Cutolo Maurizio , Bos Reinhard , Opris-Belinski Daniela , Kok Marc R , Griep-Wentink Hanneke (J) R M , Klaasen Ruth , Allaart Cornelia F , Bruyn George A W , Raterman Hennie G , Voshaar Marieke J H , Gomes Nuno , Pinto Rui M A , Klausch L Thomas , Lems Willem F , Boers M 
Published: March 2021

Abstract

Objectives
Suboptimal medication adherence is a serious problem in the treatment of chronic inflammatory diseases. To measure medication adherence, electronic monitoring is regarded as superior to pill count. GLORIA is an ongoing two-year trial on the addition of low-dose (5 mg/d) prednisolone or placebo to standard care in older people (65+ years) with RA. During the entire trial, adherence is measured with electronic caps, and with pill counts. The objective is to describe medication adherence patterns, and to compare the adherence results of the two methods.

Methods
The recorded adherence patterns of patients (blinded for treatment group) were classified according to descriptive categories. The cutoff for good adherence was set at 80% of prescribed pills taken.

Results
Trial inclusion closed in 2018 at 451 patients, but trial follow-up is ongoing; the current dataset contains adherence data of 371 patients. Mean number of recorded 90-day periods per patient was 4 (range 1–8). Based on pill count over all periods, 90% of the patients had good adherence; based on cap data, only 20%. Cap data classified 30% of patients as non-user (&lt;20% of days an opening) and 40% as irregular user (different adherence patterns, in or between periods).

Conclusion
In our trial of older people with RA, the majority appeared to be adherent to medication according to pill count. Results from caps conflicted with those of pill counts, with patterns suggesting patients did not use the bottle for daily dispensing, despite specific advice to do so.

Trial registration
NCT02585258. ClinicalTrials.gov (https://www.clinicaltrials.gov/)
Reanalysis of the Pfizer mRNA BNT162b2 SARS-CoV-2 vaccine data fails to find any increased efficacy following the boost: Implications for vaccination policy and our understanding of the mode of action
Authors: Saul Allan , Drummer Heidi E. , Scott Nick , Spelman Tim , Crabb Brendan S. , Hellard Margaret 
Published: March 2021

AbstractBackgroundIn clinical trials two vaccinations with mRNA vaccines have shown high efficacy in preventing COVID-19. However, in the context of a pandemic, the time to generation of protective immunity, the need for and timing of a second vaccination are matters of legitimate debate. This manuscript explores the efficacy and timing of the second dose COVID-19 vaccines, including a reanalysis of data from the Pfizer mRNA BNT162b2 mRNA SARS-CoV-2 vaccine phase 3 study.Methods and findingsA non-weighted three-segment, two knot linear regression was fitted to the published cumulative infection incidence from the Pfizer BNT162b2 vaccine Phase III trial using the lspine routine in R. The optimal knot days were estimated through sensitivity analysis and the confidence limits for efficacy estimates were determined by Monte Carlo Simulations. This analysis showed the vaccine was effective from day 11 post first vaccination. The estimated efficacy over the period 11 to 28 days post first vaccination was 0.94 and there was no detectable increase in efficacy following the second vaccination. The efficacy post first vaccination substantially preceded the development of detectable serum neutralizing antibody.ConclusionsStrongly protective immunity develops rapidly following a single vaccination and at least in the short period covered by the timetable of the Phase III trial, there was no additional benefit from a second vaccination. This increases options for use of this vaccine, e.g., for ring fence vaccination, for use in travelers and for mass vaccination rollout. It highlights the need for further research into duration of immunity following a single vaccination and for understanding mechanisms of protection.
Multi-objective Risk-based Resource Allocation for Urban Pandemic Preparedness: The COVID-19 Case in Bogotá, Colombia
Authors: Prieto Jeisson , Gomez Jonatan 
Published: March 2021

ABSTRACTDetermining how best to allocate resources to be used during a pandemic is a strategic decision that directly affects the success of pandemic response operations. However, government agencies have finite resources, so they can’t monitor everything all of the time: they have to decide how best to allocate their scarce resources (i.e., budget for antivirals and preventive vaccinations, Intensive Care Unit (ICU), ventilators, non-intensive Care Unit (non-ICU), doctors) across a broad range of risk exposures (i.e., geographic spread, routes of transmission, overall poverty, medical preconditions). This paper establishes a comprehensive risk-based emergency management framework that could be used by decision-makers to determine how best to manage medical resources, as well as suggest patient allocation among hospitals and alternative healthcare facilities. A set of risk indexes are proposed by modeling the randomness and uncertainty of allocating resources in a pandemic. The city understudy is modeled as a Euclidean complex network, where depending on the neighborhood influence of allocating a resource in a demand point (i.e., informing citizens, limit social contact, allocate a new hospital) different network configurations are proposed. Finally, a multi-objective risk-based resource allocation (MoRRA) framework is proposed to optimize the allocation of resources in pandemics. The applicability of the framework is shown by the identification of high-risk areas where to prioritize the resource allocation during the current COVID-19 pandemic in Bogotá, Colombia.