bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obsessive beliefs and subtypes of obsessive-compulsive symptoms amongst immigrant children and early adolescents
Authors: Pozza Andrea , Coluccia Anna , Casale Silvia , Marazziti Donatella , Mucci Federico , Gualtieri Giacomo , Lorenzi Lore , Ferretti Fabio , Dèttore Davide 
Published: March 2021

Abstract
Background. Vulnerability factors for obsessive-compulsive (OC) features in immigrant youth are under-studied. The migration process can have a highly stressful impact on the psychological wellbeing of the individual and it may represent a precipitating factor for different forms of psychopathology. Little is known about the occurrence of OC traits. Unlike other European countries, immigration to Italy is a recent phenomenon. In community children/early adolescents, this study compared OC general symptoms/subtypes and vulnerability cognitive factors amongst Italian natives, first- and second-generation immigrants, and examined whether such vulnerability factors moderate the relation between immigrant status and OC symptoms/subtypes, beyond socio-demographic/clinical variables. Methods. Two hundred sixty-eight children/early adolescents (99 natives, 82 and 87 first- and second-generation immigrants respectively) completed the Obsessive Belief Questionnaire-Child Version, Obsessive Compulsive Inventory-Child Version, Spence’s Children Anxiety Scale, Children’s Depression Inventory.Results. As compared with the other groups, first-generation immigrants had the highest levels of perfectionism and threat overestimation. Both first- and second-generation immigrants had higher doubting – checking traits than natives. First-generation immigrants with higher threat overestimation showed lower obsessing traits. Conclusions. Community screening programs for OC features should consider immigrant youth as a vulnerable group and, potentially, the target of an early intervention.
Differentially expressed IGF2BP2 in ovarian disorders: strongly associates with alternative splicing regulation in human granulosa cells
Authors: Zhao Feiyan , Wang Qin , Chen Tong , Zhao Xuehan , Xin Zhimin , Yang Xiaokui 
Published: March 2021

Abstract
Genome-wide interactions between RNA-binding proteins (RBPs) and RNA targets account for an important portion of post-transcriptional regulation. IGF2BP2 is associated with type 2 diabetes (T2D) and obesity and reportedly functions as an RBP that regulates a series of target genes by binding RNA transcripts. In this study, we detected the differential expression of IGF2BP2 in granulosa cells from women with ovarian disorders and performed RNA-seq and RIP-seq experiments in immortalized human granulosa cells (KGN cells) to evaluate global transcript levels and alternative splicing on KGN cells overexpressing IGF2BP2 versus controls. Our results show that IGF2BP2 preferentially binds to the 3’and 5’UTRs of mRNAs and enriches target gene expression in KGN cells. Notably, besides the conventional GGAC motif, we found a significant enrichment of a new GAAG motif within IGF2BP2-binding regions. We demonstrate that IGF2BP2 is involved in transcription regulation and alternative splicing in genes associated with follicular development. Furthermore, IGF2BP2 partly influences the expression levels of some of these alternatively spliced genes, including MBD3 and FN1, which may lead to ovarian endocrine disorders. In conclusion, we provide a transcriptome-wide analysis that demonstrates the role played by IGF2BP2 in the regulation of gene expression, transcription and alternative splicing of a number of genes involved in the pathogenesis of ovarian endocrine diseases.
A Path Generation Method for Wire and Arc Additive Remanufacturing of Complex Hot-forging Dies&nbsp;
Authors: Shen Yonghua , Wei Yanhong , Liu Renpei 
Published: March 2021

Abstract
Wire and arc additive remanufacturing (WAAR) technology has become a new solution for hot-forging dies repair and remanufacturing. In this study, a path generation method is proposed for WAAR of hot-forging dies. At first, a WAAR process of the hot-forging die is presented, and considering the characteristics of large welding heat input and complex 3D digital model, the hybrid path planning strategy is confirmed as an appropriate strategy for WAAR. The developed hybrid path generation method for WAAR consists of three main steps: determinate the direction of the scan line; divide and fill the internal area; and connect the sub-paths. the relatively optimal scanning direction is determined by calculating the length and inclination angle of each line segment in the contour lines, which reduces the possibility of sharp angles. The internal region is divided based on the location of the selected extreme points, and the path space is adjusted to avoid the occurrence of the underfilled phenomenon. At the stage of sub-paths connection, some criteria are proposed to reduce the number of sub-paths. At last, a planar deposition experiment and the WAAR process of four damaged hot-forging dies are carried out to validate the effectiveness and robustness of the proposed method.
Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease
Authors: Yan Jie , Li Hui , Sun Hui , Guo Haotian , Liu Jieying , Wang Mingxia , Lin Ninghua , Wang Xiangdong , Wang Xin , Li Li , Gong Yongfeng 
Published: March 2021

Abstract
Although mature podocytes lack tight junctions (TJs) and form slit diaphragms between opposing foot processes, TJ integral membrane protein CLDN5 is predominantly expressed throughout the plasma membrane of podocytes under normal conditions. Here using podocyte specific Cldn5 knockout mice as a model, we identify CLDN5 as a crucial regulator of podocyte function and reveal Cldn5 deletion exacerbates podocyte injury and proteinuria in diabetic nephropathy (DN) mouse model. Mechanistically, CLDN5 absence reduces ZO1 expression and induces the nuclear translocation of ZONAB, followed by transcriptional downregulation of WIF1, which leads to activation of WNT signaling pathway. Knockout Wif1 in podocytes result in the development of proteinuria and typical glomerular ultrastructure change occurring in Cldn5 knockout mice, while targeted delivery of Wif1 to podocytes prevents the development of glomerular nephropathy in Cldn5 knockout diabetic mice. Podocyte-derived WIF1 also plays a paracrine role on tubular epithelial cells, evidenced by animals with podocyte deletion of Cldn5 or Wif1 have worse kidney fibrosis after unilateral ureteral obstruction when compared with littermate controls with intact podocyte WIF1 expression. These findings establish a novel function of podocyte CLDN5 in restricting WNT activity in the kidney.
Effect of Repetitive Transcranial Magnetic Stimulation on Depression and Cognition in Individuals With Traumatic Brain Injury: A Meta-Analysis
Authors: Tsai Ping-Yen , Chen Yang-Ching , Wang Jia-Yi , Chung Kuo-Hsuan , Lai Chien-Hung 
Published: March 2021

Abstract
Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains inconclusive. We conducted a meta-analysis to assess the effectiveness of executing rTMS over dorsolateral prefrontal cortex (DLPFC) on depression, cognitive impairment and post-concussion syndrome in individuals with traumatic brain injury. This study contained seven randomized controlled trials that published before April 5, 2020 in PubMed, Embase, Scopus, Cochrane, and Web of Science databases. The rTMS had significant anti-depressant effect (SMD = 1.03), but the effects dissipated at one-month follow-up (SMD = 0.39). In the subgroup analysis, only applying rTMS to left DLPFC area of post-TBI patients showed significant anti-depressant effect (SMD = 0.98). Moreover, current data observed that rTMS on post-TBI patients possessed substantial improvement in visuospatial memory (SMD = 0.39), but wasn’t in processing speed (SMD = -0.18) and selective attention (SMD = 0.21). In addition, the effect of rTMS on postconcussion syndrome was insignificant. In conclusion, the short-term antidepressant effect of left DLPFC rTMS in patients with TBI was significant. Furthermore, the effectiveness of rTMS on cognition and post-concussion syndrome in patients with post-TBI depression was limited.
WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)
Authors: Wu Yayun , Ren Yun , Cao Zhimin , Zhang Kai , Dong Xiaoqiang , Lv Qinjing , Wang Bowen , Yao Wei 
Published: March 2021

Abstract
Objective To explore the association between single nucleotide polymorphism (SNP) in the XRCC3 rs861539(Thr241Met) locus and thyroid cancer risk. Methods Studies investigating the association between SNP in the XRCC3 gene and thyroid cancer susceptibility were retrieved from the PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), WanFang, and CBM (China Biology Medicine) databases. Eligible studies were screened according to inclusion/exclusion criteria and principles of quality evaluation. Meta-analysis was performed using Stata 14.0 software. Odds ratios with their corresponding 95% confidence intervals were pooled to assess the association between SNP in the XRCC3 gene rs861539 locus and thyroid cancer susceptibility. Results 10 articles(11 studies) were eligible for this meta-analysis. Meta-analysis results were shown as follows: No significant association was found between XRCC3 rs861539 polymorphism and thyroid cancer risk in Dominant and Overdominant models〔Dominant model: CT+TT vs CC, OR=1.231, 95% CI(0.998, 1.474); Overdominant model: CT vs TT+CC, OR=1.05, 95% CI(0.94, 1.18)〕. Significant associations were found in Recessive and Allelic models〔Recessive model: TT vs CC+CT, OR=1.632, 95% CI(1.349, 1.974); Allelic model: T vs C: OR=1.263, 95% CI(1.091, 1.462)〕. Conclusion The results of this study suggest that the XRCC3 rs861539(Thr241Met) polymorphism may be associated with an increased thyroid cancer risk in overall population, and a tendency for significantly increased thyroid cancer risk in TT(Met/Met) genotype population.
2D-wavelet Based Micro and Macro Texture Analysis for Asphalt Pavement Under Snow or Ice Condition
Authors: Li Feng , Ablat Gulnigar , Zhou Siqi , Liu Yixin , Weng Zihang , Du Yuchuan 
Published: March 2021

Abstract
In ice and snow weather, the surface texture characteristics of asphalt pavement change, which will significantly affect the skid resistance performance of asphalt pavement. In this study, five asphalt mixture types of AC-5, AC-13, AC-16, SMA-13, SMA-16 were prepared under three conditions of the original state, ice and snow. In this paper, a 2D-wavelet transform approach is proposed to characterize the micro and macro texture of pavement. The Normalized Energy (NE) is proposed to describe the pavement texture quantitatively. Compared with the mean texture depth (MTD), NE has the advantages of full coverage, full automation and wide analytical scale. The results show that snow increases the micro-scale texture because of its fluffiness, while the formation of the ice sheets on the surface reduces the micro-scale texture. The filling effect of snow and ice reduces the macro-scale texture of the pavement surface. In a follow-up study, the 2D-wavelet transform approach can be applied to improve the intelligent driving braking system, which can provide pavement texture information for the safe braking strategy of driverless vehicles.
A New Physiologic Based Integrated Algorithm in the Management of Neonatal Hemodynamic Instability
Authors: Elsayed Yasser , Wahab Muzafar Abdul 
Published: March 2021

Abstract
Physiologic based management of hemodynamic instability is proven to guide to logical selection of cardiovascular approach, and shorten time to clinical recovery, compared to empiric approach which is ignoring the heterogeneity of the hemodynamic instability related mechanisms. In this report we classified neonatal hemodynamic instability, circulatory shock, and degree of compensation to 5 physiologic categories, based on blood pressure (BP) different phenotypes, other clinical parameters, echocardiography markers, and oxygen indices. This approach is focused on hemodynamic instability in infants with normal heart structure.
The prediction ability of coping strategies in mental ill-health indicators among frontline workers during coronavirus pandemic
Authors: Al-Ziadat Mariam , Shattal Moutssem Abu 
Published: March 2021

Abstract
Background: Many frontline workers are at high risk of the infection of coronavirus and they might develop mental ill- health indicators particularly fear of coronavirus and Posttraumatic stress disorders. Literature reviews revealed that this depends on their coping strategies which are rarely discussed and investigated within Jordanian context. This study aims at investigating the prediction ability of the coping strategies in mental ill-health indicators among frontline workers during coronavirus pandemic. Participants are 408 volunteer frontline workers; 17.2%females and 82.8%males. Ages ranged between (less than 25 and over than 25) years, work place (Ministry of Health 54.5% and Civil Defense 45.5%), Major (doctors 18.6%, nurses 21.6%, paramedic 33.3%, others 26.5%). Participants are asked to fill out online self-report measures of brief coping, fear of coronavirus and Posttraumatic stress disorders.Results: The results show that coping strategies predicted 28.8% of the variance in fear of coronavirus and 43.6% of the variance in Posttraumatic stress disorders. Moreover, there is a low level of fear of coronavirus and Posttraumatic stress disorders also there are no significant differences in the level of fear of coronavirus in favor to study variables. At the same time, there are significant differences in the level of Posttraumatic stress disorders in favor to males: but not for other study variables. Conclusion: Mental ill-health indicators are predicted by coping strategies that frontline workers use.
Arterial Calcifications and Osteoprotegerin in Chronic Hemodialysis Patients – Impact on 6 Years Survival
Authors: Moldovan Diana , Rusu Crina , Potra Alina , Bondor Cosmina , Ticala Maria , Tirinescu Dacian , Coman Anca , Orasan Olga , Moldovan Ioan , Orasan Remus , Kacso Ina Maria 
Published: March 2021

Abstract
The study goal was to assess the impact of each type of arterial intimal calcifications (AIC) and arterial medial calcifications (AMC) identified on ultrasound, of osteoprotegerin (OPG), mineral metabolism markers and other features on all-cause and cardiovascular mortality in chronic hemodialysis patients. Ultrasound was performed in 87 patients on the carotid and femoral arteries, and the severity of AIC and AMC was assessed calculating a score according to the extension of calcification. The cut-off value for OPG determined using ROC was 4.9 pmol/L for all-cause and cardiovascular mortality. Patients with higher serum OPG levels presented higher mortality rates. Our results revealed that AIC, high OPG, low ankle-arm index, presence of diabetes, smoking status, and lack of arteriovenous fistula are associated with all-cause and cardiovascular mortality in univariate regression analysis. Multivariate analysis identified AIC scoring based on the segmentation method as an independent predictor of all-cause and cardiovascular mortality, along with increased OPG levels. AMC scoring was not a predictor of mortality. Identifying and scoring AIC on ultrasound and measuring OPG levels, as a basis of the HD patient assessment may become valuable tools in clinical work, as these have an impact on death toll.
Multifunctional Nanoplatforms as Cascade-Responsive Drug-Delivery Carriers for Effective Synergistic Chemo-Photodynamic Cancer Treatment
Authors: Li Fan , Liang Yan , Wang Miaochen , Xu Xing , Zhao Fen , Wang Xu , Sun Yong , Chen Wantao 
Published: March 2021

Abstract
Synergistic chemo-photodynamic therapy has attracted increasing attention in the field of cancer treatment. Herein, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability was fabricated, which could implement effective synergistic chemo-photodynamic cancer treatment. In this micellar nanoplatform, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (Por), a photodynamic therapy (PDT) agent, was utilized to carry the novel anticancer drug GNA002 to construct a hydrophobic core, and cyclic RGD peptide (cRGD)-modified polyethylene glycol (PEG) (cRGD-PEG) connected the cell-penetrating peptide hexaarginine (R6) through a pH-responsive hydrazone bond (cRGD-PEG-N=CH-R6) to serve as a hydrophilic shell for increasing blood circulation time. After passively accumulating in tumor sites, the self-assembled GNA002-loaded nanoparticles were actively internalized into cancer cells via cRGD ligands. Once phagocytosed by lysosomes, the acidity-triggered detachment of the cRGD-PEG shell led to the formation of R6-coated secondary nanoparticles and subsequent R6-mediated nucleus-targeted drug delivery. Combined with GNA002-induced nucleus-specific chemotherapy, reactive oxygen species produced by Por under 532-nm laser irradiation achieved a potent synergistic chemo-photodynamic cancer treatment. Moreover, our in vitro and in vivo anticancer investigations proved this ideal multifunctional nanoplatform showed a high cancer-suppression efficacy and could be a promising candidate for synergistic anticancer therapy.
Comparison of VividTrac®, King Vision® and Macintosh laryngoscopy for normal and difficult airways during simulated cardiopulmonary resuscitation among novices
Authors: Keresztes Dóra , Mérei Ákos , Rozanovic Martin , Nagy Edina , Kovács-Ábrahám Zoltán , Oláh János , Maróti Péter , Rendeki Szilárd , Nagy Bálint , Woth Gábor 
Published: March 2021

Abstract
Background: Successful early endotracheal intubation improves neurological outcomes in cardiopulmonary resuscitation. However, endotracheal intubation should not compromise cardiopulmonary resuscitation effectiveness and thus requires experience. The use of videolaryngoscopes might decrease the number of attempts as well as the time needed for intubation, especially among novice users. We sought to compare videolaryngoscopes with direct laryngoscopy in simulated cardiopulmonary resuscitation scenarios in mannequins by novices.Methods: Forty-four medical students were recruited to serve as novice users. Following brief, standardized training, students were asked to execute endotracheal intubation with each of the devices, including the King Vision®, the Macintosh laryngoscope and the VividTrac®, on acardiopulmonary resuscitation trainer (Ambu Man Advanced®) in normal and difficult airway scenarios. We evaluated the time to and the proportion of successful intubation, the best view of the glottis, esophageal intubation, dental trauma and user satisfaction.Results: In the normal airway scenario, significantly shorter intubation times (P < 0.05) were measured by King Vision®than by Macintosh laryngoscope. However, VividTrac® was proven to be similar (P > 0.05) to Macintosh laryngoscope in this regard in the normal airway scenario. In the difficult airway scenarios, we found VividTrac® superior (P < 0.05) to King Vision® and Macintosh laryngoscope regarding laryngoscopy times, but there were no significant differences between devices in intubation times. In both normal and difficult airway cardiopulmonary resuscitation scenarios, we noted no difference (P > 0.05) in first attempt success rates, the best view of the glottis and dental trauma, but esophageal intubation and the use of bougie were more frequent (P < 0.05) withMacintosh laryngoscopethan with videolaryngoscopes. The shortest tube insertion times were related to King Vision® in both scenarios.Conclusion: Based upon our results, King Vision®was superior to Macintosh laryngoscoperegarding intubation time in the normal airway cardiopulmonary resuscitation scenario for novice users. We noted significantly less esophageal intubationwhen using videolaryngoscopes compared to Macintosh laryngoscope in both scenarios; thus,videolaryngoscopes might be recommended for novice users for both cardiopulmonary resuscitation scenarios.
Quality of life measurement in community-based aged care – understanding variation between clients and between care service providers
Authors: Siette Joyce , Jorgensen Mikaela L. , Georgiou Andrew , Dodds Laura , McClean Tom , Westbrook Johanna I. 
Published: March 2021

Abstract
Background Measuring person-centred outcomes and using this information to improve service delivery is a challenge for many care providers. We aimed to identify predictors of QoL among older adults receiving community-based aged care services and examine variation across different community care service outlets.Methods A retrospective sample of 1141 Australians aged ≥ 60 years receiving community-based care services from a large service provider within 19 service outlets. Clients’ QoL was captured using the ICEpop CAPability Index. QoL scores and predictors of QoL (i.e.sociodemographic, social participation and service use) were extracted from clients’ electronic records and examined using multivariable regression.Funnel plots were used to examine variation in risk-adjusted QoL scores across service outlets.Results Mean age was 81.5 years (SD = 8) and 75.5% were women. Clients had a mean QoL score of 0.81 (range 0–1, SD = 0.15). After accounting for other factors, being older (p < 0.01), having lower-level care needs (p < 0.01), receiving services which met needs for assistance with activities of daily living (p < 0.01), and having higher levels of social participation (p < 0.001) were associated with higher QoL scores. Of the 19 service outlets, 21% (n = 4) had lower mean risk-adjusted QoL scores than expected (< 95% control limits) and 16% (n = 3) had higher mean scores than expected.Conclusion Using QoL as an indicator to compare care quality may be feasible, with appropriate risk adjustment. Implementing QoL tools allows providers to measure and monitor their performance and service outcomes, as well as identify clients with poor quality of life who may need extra support.Trial registration: Australian and New Zealand clinical trial registry number: ACTRN12617001212347. Registered 18/08/2017
COVID-19 Outbreak and Dental Health Care Provision in Nigeria – A National Survey
Authors: ALADELUSI Timothy Olukunle , ATIBA Foluso Ayobami , GBADEBO Shakeerah Olaide , ADEYEMO Yewande Isabella , OLUSANYA Adeola Adenike , AKADIRI Oladimeji Adeniyi 
Published: March 2021

Abstract
Background: The impact of the COVID-19 pandemic on the world is unprecedented, posing greater threats to vulnerable healthcare systems, especially in developing countries. This study aimed to assess the knowledge of dental healthcare providers in Nigeria about the disease and evaluate their responses to the preventive measures necessitated by the disease.Methods: This was an online self-administered questionnaire-based study conducted among Dentists practicing in Nigeria. A message containing the link to the survey was sent widely via social medial platforms and electronic mails to dentists practicing in Nigeria. The data collection was done between the 2nd of June and 3rd of July, 2020.Results: A total of 314 responses was recorded. Fever was the most commonly specified generalized symptom (97.5%), while the use of masks (100%), hand hygiene (99.7%), social distancing (97.7%) and surface cleaning (99.4%) were the most commonly employed general preventive methods. The main identified risk of transmission in the clinic was aerosol generating procedures (98.7%).Conclusion: The general knowledge of dental personnel in our study population appears to be adequate on the common features of COVID-19 but less adequate regarding the less common features. The COVID-19 pandemic has also modified some aspects of dental service delivery but more needs to be done in this regard.Preventive measures against the transmission of COVID-19 in dental practice settings include proper utilization of teledentistry, clinical triage, preprocedural 1% hydrogen peroxide oral rinses, and the use of appropriate PPEs which should always be encouraged.