bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Administration Practices in Hospitalized Periparturient Goats: A Multicenter Study
Authors: Luethy Daniela , Cabrera Catalina , Coll‐Roman Lisette M. , VanderBroek Ashley R. , Depenbrock Sarah M. , Bauck Anje G. , Kelleman Audrey A. , Stockler Jenna W. , Scully Clare , Wiley Caitlin , Mackay Evelyn E. , Abraham Michelle , Leduc Laurence , Noll Charlene V. , Fecteau Marie‐Eve , Redding Laurel E. 
Published: February 2025

ABSTRACTBackgroundUnderstanding antimicrobial use practices in goats is essential to ensuring appropriate antimicrobial stewardship.ObjectiveTo describe antimicrobial prescriptions in periparturient does admitted to veterinary teaching hospitals and to determine if any factors were associated with the administration of antimicrobials in general or ceftiofur in particular.AnimalsOne hundred ninety‐eight periparturient does presented to nine university veterinary hospitals from October 2021 to June 2022.MethodsA multicenter cross‐sectional study in a prospective design. Data were collected from questionnaire completed by admitting clinician.ResultsOut of 198 periparturient does included in the study, 153 (77%) received antimicrobials during hospitalization. Commonly administered antimicrobials included oxytetracycline (n = 44, 29%), ceftiofur sodium (n = 43, 28%), ceftiofur crystalline free acid (CCFA; n = 27, 18%), potassium penicillin G (n = 15, 10%), procaine penicillin G (n = 14, 9%), florfenicol (n = 14, 9%), tulathromycin (n = 9, 6%), ampicillin trihydrate (n = 4, 3%), and ampicillin sodium (n = 1, 1%). Cesarean section was associated with antimicrobial administration in general (OR = 5.89; 95% CI = 2.49–13.98, p < 0.01) and with ceftiofur administration (OR = 2.54, 95% CI = 1.25–5.17; p = 0.008). Significant variability in ceftiofur administration by hospital was observed (p < 0.001).Conclusions and Clinical ImportanceMarked heterogeneity was observed in the antimicrobial administration practices in periparturient goats between nine US veterinary teaching hospitals.
Modified carbon dot‐mediated transient transformation for genomic and epigenomic studies in wheat
Authors: She Linwei , Cheng Xuejiao , Jiang Peng , Shen Simin , Dai Fangxiu , Run Yonghang , Zhu Mengting , Tavakoli Mahmoud , Yang Xueming , Wang Xiu‐e , Xiao Jin , Chen Caiyan , Kang Zhenhui , Huang Jian , Zhang Wenli 
Published: February 2025

SummaryGenotype restriction poses a significant bottleneck to stable transformation in the vast majority of plant species, thereby severely impeding advancement in plant bioengineering, particularly for crops. Nanoparticles (NPs) can serve as effective carriers for the transient delivery of nucleic acids, facilitating gene overexpression or silencing in plants in a genotype‐independent manner. However, the applications of NP‐mediated transient systems in comprehensive genomic studies remained underexplored in plants, especially in crops that face challenges in genetic transformation. Consequently, there is an urgent need for efficient NP‐mediated delivery systems capable of generating whole plants or seedlings with uniformly transformed nucleic acids. We have developed a straightforward and efficient modified carbon dot (MCD)‐mediated transient transformation system for delivering DNA plasmids into the seeds of wheat, which is also applicable to other plant species. This system facilitates the generation of whole seedlings that contain the transferred DNA plasmids. Furthermore, our study demonstrates that this system serves as an excellent platform for conducting functional genomic studies in wheat, including the validation of gene functions, protein interactions and regulation, omics studies, and genome editing. This advancement significantly enhances functional genomic research for any plants or crops that face challenges in stable transformation. Thus, our study provides for the first time evidence of new applications for MCDs in functional genomics and epigenomic studies, and bioengineering potentially leading to the improvement of desirable agronomic traits in crops.
Oxidative post‐translational modifications of plant antioxidant systems under environmental stress
Authors: Jiménez Ana , Martí María Carmen , Sevilla Francisca 
Published: February 2025

AbstractPlants are often subject to environmental challenges posed by abiotic and biotic stresses, which are increasing under the current climate change conditions, provoking a loss in crop yield worldwide. Plants must cope with adverse situations such as increasing temperatures, air pollution or loss of agricultural land due to salinity, drought, contamination, and pathogen attacks, among others. Plants under stress conditions increase the production of reactive oxygen‐, nitrogen‐, and sulphur species (ROS/RNS/RSS), whose concentrations must be tightly regulated. The enzymatic antioxidant system and metabolites are in charge of their control to avoid their deleterious effects on cellular components, allowing their participation in signalling events. As signalling molecules, reactive species are involved in plant responses to the environment through post‐translational modifications (PTMs) of proteins, which, in turn, may regulate the structure, function, and location of the antioxidant proteins by oxidative/nitrosative/persulfure modifications of different amino acid residues. In this review, we examine the different effects of these post‐translational modifications, which are emerging as a fine‐tuned point of control of the antioxidant systems involved in plant responses to climate change, a growing threat to crop production.
“Not social workers, but social fighters”: Navigating the search for macro social work identity in the Aotearoa New Zealand Social Work Journal
Authors: LaMontagne Olivia , Crichton-Hill Yvonne , Maidment Jane 
Published: February 2025

Introduction: Given the social work profession’s roots in social justice and recognising the social determinants of wellbeing, macro social work is an essential part of the professional identity. However, macro work is often a marginalised part of the profession because of an increasing focus on clinical work due to the rise of neoliberalism and practical barriers.
Methods: To better understand macro social work’s place in the profession, this research sought to assess the historical and current discourses surrounding macro social work in Aotearoa New Zealand. To do this, a qualitative interpretive meta-synthesis was conducted on publications of the Aotearoa New Zealand Social Work Journal since it began in 1965 to 2020. This meta-synthesis was one part of a broader study on macro social work for a PhD thesis.
Findings: The analysis focused on finding journal articles that relate to macro social work to generate themes around how social workers think and feel about the place of macro social work in the profession. Themes around historical trends, scope of practice and the status of the profession were discussed in the context of macro social work and social change. The themes illuminated key tensions between micro and macro social work in the professional identity.
Conclusions: This article makes a case for bridging the divide between micro and macro work and increasing the discussion of macro social work in the professional discourse in the Journal and beyond.
Selling Out in the High Country
Authors: Lawn Jennifer 
Published: February 2025

Eleanor Catton, Birnam Wood, Wellington: Te Herenga Waka University Press, 2023, 423 pp
Among the many pleasures of reading Eleanor Catton’s idiosyncratic fiction is her sheer inventiveness, the sense that she likes to set herself difficult or even improbable writing challenges. Her works hover on the boundaries of established genres—coming of age in her first novel The Rehearsal (2008), crime fiction in The Luminaries (2013)—while refusing to abide by genre conventions. The Rehearsal could be seen as an anti-creative work: set in a performing arts school, the novel presents a caustic take on training in creative arts as ego-eviscerating initiation. The Luminaries arbitrarily (for many readers) fuses the extrinsic numerical patterns of Western astrology with a character-based historical murder mystery cum neo-Victorian sensation novel. Catton’s most recent novel, Birnam Wood, offers another kind of formal conundrum.
Transforming the E-waste Management System
Authors: Ibrahim Sarah 
Published: February 2025

The aim of this research is to inform the transformation of the e-waste management in Dunedin by shifting the focus from recycling to activities higher in the waste hierarchy (for example, redesigning, reducing and refurbishing). Previous research has identified the importance and potential solutions of creating a circular economy for e-waste, but few have addressed the context of Dunedin's social and environmental economy. To gain insight into how Dunedin’s climate influences the e-waste management system, semi-structured interviews were conducted with 12 stakeholders involved in the production, processing and diversion of e-waste. The interviews focused on understanding current e-waste management practices, identified barriers and explored opportunities for collaboration with other stakeholders. A review of global 'good practice' e-waste management provided a benchmark for evaluating and potentially replicating effective e-waste management strategies in New Zealand. This article documents Dunedin’s current e-waste management practices and provides recommendations to guide stakeholders in the e-waste sector. These recommendations particularly focus on supporting product stewardship schemes, prioritising public awareness and education, and encouraging joint solutions. The findings from this article could serve as a model for other regions in New Zealand, promoting sustainable consumption and production patterns.
From Locker Room to Limelight: Exploring College Athlete Heightened Visibility, Branding Challenges, and Safety in the Age of Name, Image, and Likeness
Authors: Brown Katie M. , Esho Adebowale , Sanderson Jimmy 
Published: February 2025

The name, image, and likeness (NIL) era in college sports has opened doors for athletes to monetize their popularity through endorsement deals, resulting in a transformation of their status into influencers and celebrities. This paper examines the multifaceted implications of the NIL deals, spotlighting how some college athletes manage their brands and navigate their newfound celebrity status. This analysis delves into the challenges athletes face, such as in-person safety concerns from both peers and strangers, and the responsibilities universities might have to ensure athlete well-being. Moreover, it explores whether institutions have a duty to protect athletes, provide education on brand management and financial literacy, or whether athletes are left to navigate these aspects on their own. By scrutinizing existing guidelines, ethical frameworks, and real-world cases, this paper aims to contribute to the practitioner’s understanding of the complex landscape surrounding college athletes’ heightened visibility and increased popularity, brand management, and safety.
Identifying haemochromatosis patients with C282Y homozygosity from inpatient electronic patient records in England using a novel algorithm: a retrospective observational study
Authors: Singh Prabhsimran , Millson Charles , Huang Chao , Driver Robert J 
Published: February 2025

IntroductionHereditary haemochromatosis (HH) is the most common genetic condition among populations of northern European ancestry, but it does not have a specific International Classification of Diseases 10th revision (ICD-10) diagnosis code. HH is commonly assigned the ICD-10 code E83.1 defined as ‘disorders of iron metabolism’. However, the E83.1 diagnosis code is also applied to patients with transfusion-related iron overload and hyperferritinaemia from non-iron loading conditions. Venesection is the main treatment option for patients with HH and is assigned the Office of Population, Census and Surveys Classification of Interventions and Procedures, 4th revision (OPCS-4) code X36.2. We aimed to develop a novel algorithm to identify haemochromatosis patients with C282Y homozygosity from electronic patient records (EPR) using ICD-10 and OPCS-4 codes.MethodsThe Hospital Episode Statistics Admitted Patient Care (APC) database was used to identify all patients with the ICD-10 code E83.1 from 1 April 2018 to 31 March 2023 in our NHS Trust. Case notes were reviewed to evaluate the presence of HH, genotype, medical history and associated procedures. Algorithms were generated using Stata MP V.18 by applying a combination of ICD-10 and OPCS-4 codes to all patients with the diagnosis code E83.1 including those without HH gene mutations.ResultsA total of 9264 patient episodes were identified from the HES APC database corresponding to 787 unique patients: 479 (60.9%) C282Y homozygous, 107 (13.6%) C282Y/H63D compound heterozygotes, 42 (5.3%) other HH genetic mutations and 159 (20.2%) without any HH gene mutations. Six algorithms were developed to identify patients with HH within inpatient EPR, all of which showed improved positive predictive value (PPV) compared with the baseline cohort. The application of the OPCS-4 code for venesection (X36.2) in five of the algorithms resulted in large improvements in specificity and increased all their PPVs to >70%. Algorithms 4 and 6 had the best PPV at 74.3% and 74.4%, respectively, and included the removal of patients with ICD-10 codes associated with transfusion-related iron overload and other conditions treated with venesection.ConclusionThese novel algorithms represent a more reliable method to detect haemochromatosis patients with C282Y homozygosity from EPR than the single ICD-10 code E83.1. It may be applied to large administrative datasets for investigation of HH in population studies.
AMI-Sleep: protocol for a prospective study of sleep-disordered breathing/sleep apnoea syndrome and incident cardiovascular events after acute myocardial infarction
Authors: Balagny Pauline , D’Ortho Marie-Pia , Berard Laurence , Rousseau Alexandra , Gourmelen Julie , Ravaud Philippe , Durand-Zaleski Isabelle , Simon Tabassome , Steg Philippe Gabriel 
Published: February 2025

IntroductionSleep-disordered breathing (SDB) and the related clinical syndrome, sleep apnoea syndrome (SAS), are highly prevalent in patients with ischaemic heart disease and often remain undiagnosed. The AMI-Sleep study will describe its prevalence in patients with acute myocardial infarction (AMI) and assess the independent contribution of the type and severity of SDB/SAS to subsequent incident cardiovascular events and mortality.Methods and analysisThis prospective study will include patients hospitalised for AMI enrolled in the multicentre nationwide prospective French Cohort of Myocardial Infarction Evaluation (FRENCHIE) registry. A nightly simplified polygraphy is performed before discharge from the index AMI admission, and participants complete two self-administered sleep questionnaires. Baseline data are obtained from the FRENCHIE registry. Each participant will be subsequently followed based on data from the National Health Data System (SNDS). Over a period of 4 years, the AMI-Sleep study is expected to recruit approximately 2000 participants. Assuming at least a 10% rate of incident cardiovascular events over 1 year, there would be an estimated 200 events during the first year of follow-up that would be sufficient in multivariable analysis. The primary objective is to describe the prevalence and severity of SDB in AMI and to analyse the association between the type and severity of SDB (based on the apnoea-hypopnoea index) and the occurrence of cardiovascular events (incident acute coronary syndrome, transient ischaemic attack, stroke) or all-cause death after AMI. Secondary objectives include determining the association between the presence of SAS and coronary artery disease severity, in-hospital mortality, morbidity events, healthcare consumption and related costs.Ethics and disseminationEligible individuals are provided with information about the AMI-Sleep study and provided written informed consent. The protocol was approved by the regional Ethics Committee (CPP Ouest II – Angers, RCB N°2018-A00719-46) on 17 February 2019, is registered on ClinicalTrials.gov (NCT04064593) and started in January 2019 with the expected publication of primary outcome results in 2025.Trial registration numberClinicalTrials.gov,NCT04064593.
Association of herpes zoster vaccination and cardiovascular risk in patients with diabetes: long-term insights from a retrospective cohort study
Authors: Kornelius Edy , Lo Shih-Chang , Huang Chien-Ning , Wang Chi-Chih , Wang Yu-Hsun , Yang Yi-Sun 
Published: February 2025

ObjectivesHerpes zoster (HZ) infection is associated with a higher risk of major adverse cardiovascular events (MACE), including stroke and coronary artery disease (CAD). Patients with diabetes are at an increased risk of MACE, highlighting the importance of studying this population to assess the potential protective effects of HZ vaccination. This study aims to investigate the risk of MACE after HZ vaccination in patients with diabetes.DesignRetrospective cohort study.SettingCommunity-based population in the USA.ParticipantsUsing the TriNetX database, the study included 4.9 million patients with diabetes from 2006 to 2022. It established two cohorts: 68 178 patients in the HZ vaccination (comprising any HZ vaccine, Shingrix or Zostavax) and 4 835 246 patients in the no HZ vaccination group. After excluding patients with a history of MACE, immune disease and complications of HZ prior to the index date, the study cohort was reduced to 45 960 patients. Propensity score matching, accounting for age, sex, race, socio-economic status and disease comorbidities, was conducted to minimise study bias.InterventionsHZ vaccination.Outcome measuresMACE outcomes are defined as the first occurrence of CAD or stroke. Comparative risk analysis was conducted using HRs.ResultsPost matching, the mean patient age was 63.5 years, with 49.2% females. The incidence rate of MACE was lower among vaccinated patients compared with unvaccinated individuals, with an HR of 0.76 (0.72–0.79). For secondary endpoints, the HRs were 0.73 (0.69–0.78) for CAD, 0.79 (0.74–0.84) for stroke and 0.54 (0.52–0.57) for all-cause mortality. These protective effects remained consistent across different age groups, sexes and diabetes types, supporting the potential benefit of HZ vaccination in reducing cardiovascular risk.ConclusionsHZ vaccination is associated with a lower risk of MACE in patients with diabetes. Further prospective studies are critically needed to confirm this finding.
MELK study: an observational study on human milk composition and infant health determinants during the first year of life in a Dutch cohort
Authors: Petersohn Inga , Wang Peiheng , van Heumen Cindy , van Lee Linde , Hettinga Kasper Arthur , Belzer Clara , van Baar Anneloes , Feskens Edith , Brouwer-Brolsma Elske Maria 
Published: February 2025

IntroductionHuman milk plays a crucial role in infants’ nutrition and immunity, with its composition being influenced by different factors. The role of maternal diet on human milk fatty acid composition, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is well studied. Higher fish intake is associated with higher DHA levels in human milk, while fewer associations have been reported for EPA. Yet, maternal diet’s impact on human milk composition for other nutrients is understudied, and variations in sampling protocols and study quality hinder definitive conclusions on its overall impact. Ethnicity may also impact milk composition, with different dietary habits intertwined with different genetic backgrounds, but also here research lacks standardised protocols. Our study aims to investigate maternal diet, ethnicity, and their association with human milk composition, along with their potential short-term associations with infant health and development, through detailed dietary assessment and by recruiting participants from diverse backgrounds. Understanding these associations could inform the development of tailored nutritional guidelines for mothers and infants, ultimately promoting optimal health and well-being for both. The study design, with its strict sampling procedure, can guide and inspire future studies.Methods and analysisWe will conduct an observational study involving 120 healthy mothers from three ethnic backgrounds (Chinese, Caucasian and Turkish), exclusively breastfeeding their 2-month-old infants. We will collect human milk samples at two time points and assess maternal dietary intake over 4 days. Additionally, we will collect data on various maternal and child characteristics, including maternal stress, socioeconomic status and health, and infant feeding, sleeping, crying, gastrointestinal health and developmental status.Ethics and disseminationThe study has been approved by the Medical Ethical Committee Oost-Nederland (NL79447.091.21), and all participants provided written informed consent before entering the study. Findings will be widely disseminated at international conferences and meetings including the annual Nutrition & Growth conference, ESPGHAN, and through publication in scientific peer-reviewed journals.Trial registration numberISRCTN registry (ISRCTN35735283).
Determinants of unfavourable treatment outcomes of drug-resistant tuberculosis cases in Malaysia: a case–control study
Authors: Kamarul Zaman Mohd Fahmin , Nik Husain Nik Rosmawati , Sidek Mohd Yusof , Abu Bakar Zamzurina 
Published: February 2025

ObjectivesThe emergence of drug-resistant tuberculosis (DR-TB) complicates TB management and poses significant challenges to achieve favourable treatment outcomes. Treating DR-TB is more complex and costly, requiring extended treatment durations and consideration of drug toxicity and side effects. This study aims to identify the determinants of unfavourable treatment outcomes among DR-TB patients in Malaysia.DesignRetrospective case–control study.SettingSecondary data from the National Tuberculosis Registry (NTBR) across two states in Malaysia.ParticipantsAll reported DR-TB cases in the NTBR between 2016 and 2020 from Selangor and Wilayah Persekutuan Kuala Lumpur, Malaysia. Cases still undergoing treatment at the time of analysis were excluded. A total of 403 cases were analysed, with 181 (44.9%) experiencing unfavourable treatment outcomes and 222 (55.1%) having favourable treatment outcomes. The case group consists of individuals with DR-TB who experienced unfavourable treatment outcomes, while the control group comprises individuals with DR-TB who achieved favourable treatment outcomes.Outcome measuresUnfavourable treatment outcomes, defined as death, treatment failure or loss to follow-up, were assessed. Predictors of these outcomes were identified through multiple logistic regression analysis.ResultsSignificant determinants of unfavourable treatment outcomes included being male (adjusted OR (aOR) 2.38, 95% CI 1.44 to 3.94), being single or divorced (aOR 1.61, 95% CI 1.03 to 2.49), having no formal education (aOR 3.09, 95% CI 1.49 to 6.41), people living with HIV (aOR 2.87, 95% CI 1.40 to 5.87) and having DR-TB categorised as rifampicin-resistant tuberculosis (aOR 3.34, 95% CI 1.90 to 5.86) or multidrug-resistant/pre-extensively drug-resistant/extensively drug-resistant-TB (aOR 2.57, 95% CI 1.52 to 4.33).ConclusionThe findings reveal a high proportion of DR-TB cases with unfavourable treatment outcomes and identify their key determinants. Targeted interventions addressing these factors are essential to improve treatment outcomes.