bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing Effectiveness of a Community-based, Physical Activity Program for Fathers and Daughters: A Randomized Controlled Trial
Authors: Morgan Philip J , Rayward Anna T , Young Myles D , Pollock Emma R , Eather Narelle , Barnes Alyce T , Kennedy Stevie-Lee , Saunders Kristen L , Drew Ryan J , Lubans David R 
Published: July 2021

Abstract

Background
The ‘Dads And Daughters Exercising and Empowered’ (DADEE) program significantly improved physical activity levels of fathers and their daughters in an efficacy trial. However, the effectiveness of interventions when delivered in real-world settings needs to be established.

Purpose
To evaluate the effectiveness of the DADEE intervention when delivered in community settings by trained facilitators.

Methods
We conducted a two-arm RCT, (baseline and 3-months post-intervention assessments), in Newcastle, Australia. In 2016, 155 fathers (27–60 years) and 189 primary-school-aged daughters (4–12 years) (n = 344) were randomly allocated to the intervention (78 fathers, 95 daughters) or waitlist-control (77 fathers, 94 daughters) groups. Trained facilitators delivered the 9-week DADEE program (weekly sessions plus home-based tasks). Primary outcomes were fathers’ and daughters’ physical activity (steps/day). Secondary outcomes included screen-time, weight status, daughters’ fundamental movement skill (FMS) proficiency, perceived sports competence, and fathers’ parenting practices. Effects were assessed using linear mixed models.

Results
Primary outcome follow-up data were collected from 88% of fathers and 89% of daughters. Significant group-by-time differences in mean daily steps were found for fathers’ (adjusted difference = +1,638; 95% CI: 833, 2,443, d = 0.7) and daughters’ (adjusted difference = +1,023 steps/day; 95% CI: 259, 1,787; d = 0.4) physical activity. Significant effects were observed for daughters’ screen-time, FMS, and some parenting practices. No significant effects were identified for weight status, or fathers’screen-time or self-reported MVPA. Program attendance, satisfaction and fidelity were very high.

Conclusion
This study established the effectiveness of the DADEE intervention when delivered in community settings by trained facilitators. Importantly, the findings were comparable to those of the efficacy RCT delivered by the research team. To maximize public health benefits, a larger-scale dissemination of the program appears warranted.
Trial Registration Australian New Zealand Clinical Trial Registry: ACTRN12616001270404 Human Research Ethics Committee: H-2014-0330
MSCV-based retroviral plasmids expressing 3xFLAG-Sp-dCas9 for enChIP analysis
Authors: Yuno Miyuki , Nagata Shoko , Fujita Toshitsugu , Fujii Hodaka 
Published: July 2021

Abstract
Engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) is a technology for purifying specific genomic regions to facilitate identification of their associated molecules, including proteins, RNAs, and other genomic regions. In enChIP, the target genomic region is tagged with engineered DNA-binding molecules, for example, a variant of the clustered regularly interspaced short palindromic repeats (CRISPR) system consisting of a guide RNA (gRNA) and a catalytically inactive form of Cas9 (dCas9). In this study, to increase the flexibility of enChIP and expand the range of target cells, we generated murine stem cell virus (MSCV)-based retroviral plasmids for expressing dCas9. We constructed MSCV-based retroviral plasmids expressing Streptococcus pyogenes dCas9 fused to a 3xFLAG-tag (3xFLAG-Sp-dCas9) and various drug resistance genes. We showed that by using these plasmids, it is feasible to purify target genomic regions with yields comparable to those reported using other systems. These systems might give enChIP users greater flexibility in choosing optimal systems for drug selection of transduced cells.
The Impact of the COVID-19 Pandemic on Social Workers at the Frontline: A Survey of Canadian Social Workers
Authors: Ashcroft Rachelle , Sur Deepy , Greenblatt Andrea , Donahue Peter 
Published: July 2021

Abstract
Social workers are facing increasingly complex client needs during the coronavirus disease of 2019 (COVID-19) pandemic. Because of the social distancing requirements of the pandemic, social workers have undergone transformative changes in practice with the rapid uptake of virtual technologies. The objective of our study was to understand the experiences of social workers during the first-wave of the COVID-19 pandemic. We conducted a cross-sectional, web-based survey, comprised of close-ended and open-ended questions. Survey participants included social workers who were the members of a provincial social work association in Ontario, Canada. With n = 2,470 participants, the response rate was close to 40 per cent. Descriptive statistics were conducted on the close-ended questions. Two open-ended questions were coded using the thematic analysis. Nine themes were identified on the impact to social worker’s employment status: increased work-load; loss of employment; redeployment to new settings; early retirement; concern for personal health and safety; social workers in private practice seeing fewer clients; personal caregiving responsibilities; limiting recent graduates’ employment potential and social workers experiencing new opportunities. There were five themes on the impact on social work practice: clients with increasing complexities; challenges with transition to virtual care; benefits with transition to virtual care; adapting in-person services and personal well-being.
Social media and (im)mobility: implications for community development
Authors: Marlowe Jay , Chubb Laura A 
Published: July 2021

Abstract
The contemporary forced migration contexts of conflict, climate change and contagion present new challenges and opportunities for the ways in which community development is understood, practised and imagined. The accelerating trends of refugee persecution and high-impact weather events causing disasters now sit alongside the uncertainties of closed borders and rapidly evolving geopolitics. Despite these dislocations and constraints on human mobility and immobility, the possibilities for connection remain, although unevenly. Mediated predominantly through the smartphone, social media offers new opportunities, cautions and ethical considerations for the circulation of care, intimacy and trust. These flows can now significantly inform and shape everyday lives, political action and how ‘community’ is envisaged and enacted. In the ongoing context of dislocation and separation, this paper presents a longitudinal digital ethnography that examines how people from refugee backgrounds practise transnational connection and community when physical reunion is not possible. These online spaces represent opportunities to explore the implications for community development and more broadly social work education. Drawing upon the theoretical framework of the social organization of difference and its associated domains of encounters, configurations and representations, this paper articulates the possibilities and challenges for community development and more broadly social work education and practice when opportunities for physical co-presence are highly constrained.
US Hospitalizations and 60-Day Readmission Rates Associated With Herpes Simplex Virus Encephalitis: Analysis of All Cause Readmissions and Encephalopathy Associated Readmissions
Authors: Hansen Michael A , Hasbun Rodrigo 
Published: July 2021

Abstract

Background
Herpes simplex encephalitis (HSE) is the most common cause of encephalitis hospitalizations. We sought to describe and analyze features associated with all cause readmissions and encephalopathy associated readmissions amongst HSE cases.

Methods
HSE hospitalizations and 60-day rehospitalizations were assessed in a retrospective cohort using linked hospitalizations from the Healthcare Utilization Project (HCUP) National Readmission Database (NRD) from 2010 through 2017. Risk factors for all-cause readmissions and encephalopathy associated readmissions were assessed with a weighted logistic regression model.

Results
There were 10 272 HSE cases in the US between 2010 and 2017, resulting in a national rate of 4.95 per 100 000 hospitalizations. A total of 23.7% were readmitted at least once within 60-days. Patients that were readmitted were older (mean age 62.4 vs 57.9, P &lt; .001), had a greater number of procedures at the index hospitalization (adjusted odds ratio [aOR] 1.03, P &lt; .001) and have a higher Charlson comorbidity score (aOR 1.11, P &lt; .001). Among those readmitted, 465 (16.5%) had an encephalopathy related diagnosis. Over 8 years, the rate of encephalopathy associated readmissions increased from 0.12 to 0.20. Encephalopathy specific readmissions were found to be associated with greater age (mean age 65.9 vs 61.7, P = .004) and findings of cerebral edema at index hospitalization (aOR 2.16, P &lt; .001).

Conclusions
HSE readmissions are relatively common, particularly among older and sicker individuals. However, early signs and symptoms of neurological disease at index were correlated with encephalopathic specific readmissions.
Prevalence and Factors Associated With Fecal Urgency Among Patients With Ulcerative Colitis and Crohn’s Disease in the Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease
Authors: Dawwas Ghadeer K , Jajeh Hamzeh , Shan Mingyang , Naegeli April N , Hunter Theresa , Lewis James D 
Published: July 2021

Abstract

Background
In patients with ulcerative colitis (UC) and Crohn’s disease (CD), this research examined the following: prevalence of fecal urgency (hereafter urgency), association of urgency with inflammatory bowel disease (IBD) symptoms and fecal calprotectin, and association between well-being and urgency.

Methods
In this cross-sectional study from the Study of a Prospective Adult Research Cohort with IBD, urgency was categorized as none, mild, and moderate-severe. We examined the prevalence of urgency, association of urgency with IBD symptoms and fecal calprotectin (in a subset) using multinomial logistic regression, and association of well-being (not feeling well vs generally well) with urgency using logistic regression.

Results
Among 576 UC patients, 31.4% reported mild and 28.1% moderate-severe urgency. Among 1330 CD patients, 33.8% reported mild and 31.4% moderate-severe urgency. In UC, moderate-severe urgency was associated with: increased average bowel movements/day [odds ratio (OR) 1.23; 95% confidence interval: 1.09, 1.23], increased stool frequency relative to normal (OR, 9.95; 95% CI: 3.21, 30.87), rectal bleeding (OR, 3.36; 95% CI: 1.79, 6.34), moderate-severe abdominal pain (OR, 17.5; 95% CI: 5.38, 56.89), and calprotectin ≥ 250 μg/g (OR, 4.36; 95% CI: 1.50, 12.66). In CD, moderate-severe urgency was associated with: increased average bowel movements/day (OR, 1.23; 95% CI: 1.14, 1.34), increased stool frequency relative to normal (OR, 7.57; 95% CI: 3.30, 17.34), rectal bleeding (OR, 1.77; 95% CI: 1.13, 2.78), and moderate-severe abdominal pain (OR, 7.52; 95% CI: 4.31, 13.14). Reduced well-being was associated with moderate-severe urgency in both UC (OR, 4.20; 95% CI: 1.69, 20.40) and CD patients (OR, 2.52; 95% CI: 1.51, 4.22).

Conclusions
Urgency was common and associated with symptoms and biomarkers suggesting active IBD and reduced well-being.
Physiological Mechanisms of Variable Nutrient Accumulation Patterns Between Diapausing and Non-Diapausing Fall Webworm (Lepidoptera: Arctiidae) Pupae
Authors: Zhao Lvquan , Wang Wei , Qiu Ying , Torson Alex S 
Published: July 2021

Abstract
Diapause is a highly advantageous strategy for winter survival for insects living in temperate environments. However, insects typically do not feed during diapause and are therefore presented with a complicated energetics problem. The fall webworm, Hyphantria cunea, overwinter as diapausing pupae, but adults of this species lose their ability to feed due to the degeneration of their mouthparts. Thus, the energy reserves stored before diapauses contribute to the survival rate and fitness of the adults after emergence. In this study, we tested the hypothesis that diapause-destined larvae of H. cunea reserve more energy by increasing feeding rate, feeding efficiency, or both, during the diapause preparation phase compared with non-diapause-destined larvae. We observed higher digestive efficiency, increased lipase and amylase activity, and lower protease activity in diapause-destined larvae compared to non-diapause-destined larvae. These differences in digestive physiology during diapause preparation lead to greater body size and mass, increased lipid and carbohydrate content, and lower soluble protein content in diapausing pupae, relative to non-diapause pupae – results consistent with our hypothesis. We conclude that diapause-destined fall webworm reserve more energy than non-diapause-destined individuals by increasing feeding efficiency, and that this increase in efficiency is at least partially driven by increased lipase and amylase activities in the midgut. This is in contrast to non-diapause-destined larvae, which likely reserve greater protein than diapause-destined larvae to help maintain their physiological function.
Left ventricular pseudoaneurysm: an inadvertent consequence of COVID-19—a case report
Authors: Brennan Stephen , Sulong Saadah , Barrett Matthew 
Published: July 2021

Abstract

Background
Left ventricular pseudoaneurysm (LVP) is an uncommon but serious mechanical complication of acute myocardial infarction (AMI). The immediate medical complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are well recognized, but its indirect effect on patients and healthcare systems is potentially less perceivable.

Case summary
In this report, a 72-year-old man who was anxious about attending hospital during the SARS-CoV-2 pandemic was eventually found to have a total right coronary artery occlusion after a delayed emergency department presentation. He ultimately developed severe symptomatic heart failure and cardiac magnetic resonance imaging (CMR) revealed that a large LVP with concomitant severe ischaemic mitral regurgitation had evolved from his infarct. The patient was successfully discharged home after the surgical replacement of his mitral valve and repair of his LVP.

Discussion
This case highlights a salient downstream effect of Coronavirus disease 2019 (COVID-19): the delay in presentation, diagnosis, and management of common treatable conditions such as AMI. It also underscores the importance of non-invasive multimodal imaging on the timely identification of the mechanical complications of AMI. In particular, CMR can play a crucial role in the characterization and management of LVP.
A case report of a triad causing platypnoea–orthodeoxia syndrome
Authors: Fuertes-Kenneally Laura , Quiles-Granado Juan , Sánchez-Quiñones Jessica , Martínez-Martínez Juan Gabriel 
Published: July 2021

Abstract

Background
Platypnoea–orthodeoxia syndrome (POS) is a rare condition characterized by hypoxaemia and dyspnoea when changing from a recumbent to an upright position. Diagnosis requires a high clinical suspicion and is often underdiagnosed.

Case summary
We report a case of POS in a 50-year-old woman with dyspnoea and new-onset atrial fibrillation. Oxygen saturation and dyspnoea worsened as she changed from a supine to a sitting position (96 vs. 86%, respectively). Transoesophageal echocardiography demonstrated enlargement of both atria and right ventricle with reduced systolic function and a large Chiari network (CN). Colour Doppler discovered severe tricuspid regurgitation with tenting and tethering of the valve leaflets. Finally, a bubble test revealed the cause of POS to be a patent foramen ovale along with the severe tricuspid regurgitant jet moving into the left atrium and favoured by the CN. Surgical closure of the foramen ovale resulted in the resolution of symptoms.

Discussion
Platypnoea–orthodeoxia syndrome is most commonly caused by a right-to-left shunt through an anatomical defect of the interatrial septum, typically a patent foramen ovale, combined with elevated right atrium pressure. This case illustrates an uncommon cause of POS in the absence of elevated atrium pressure due to the interplay of three key elements: a patent foramen ovale, tricuspid regurgitation, and the CN. Our aim is to alert physicians to the possibility of an intracardiac shunt as the cause of unexplained and/or refractory hypoxaemia related to position changes. Early recognition of this syndrome promotes timely treatment, greatly improving patient outcomes.
When cardiac surgery comes to its limits: a case report of pericardial mesothelioma invading the myocardium
Authors: Pölzl Leo , Hirsch Jakob , Mayr Agnes , Uprimny Christian , Oberhuber Georg , Zwick Hansjörg J , Müller Ludwig , Pölzl Gerhard 
Published: July 2021

Abstract

Background
Primary pericardial mesothelioma (PPM) is a rare form of highly aggressive cancer. Many patients are diagnosed only at an advanced stage. Therefore, the overall survival rate is poor with a median survival of 3 months. In some rare cases, the PPM infiltrates the myocardium causing lethal myocardial dysfunction.

Case summary
A 66-year-old patient was transferred to our centre with the provisional diagnose of pericarditis of unknown origin. Using extensive cardiac imaging [echocardiography, computed tomography (CT), positron emission tomography–CT, cardiac magnetic resonance imaging, left and right heart catheterization, coronary angiography], PPM was finally diagnosed. After consultation with the oncologists, the heart team decided to resect the tumour first due to impaired haemodynamics and then initiate adjuvant chemotherapy. Intraoperatively, myocardial infiltration of the tumour became apparent, which was not detected preoperatively despite intensive imaging. Complete resection of the PPM was not possible and effective decompression of the ventricle could not be achieved. The patient died on the first postoperative day.

Discussion
Surgical therapy is indicated in many forms of cardiac tumours. However, when a tumour invades the myocardium, surgery often comes to its limits. In this case, myocardial invasion of PPM could not be detected despite extensive imaging. We therefore suggest that possible myocardial infiltration by PPM, and thus potential limitations of cardiac surgery, should be considered independently of imaging results when therapeutic options are discussed.
Socioeconomic Roots of Climate Change Denial and Uncertainty among the European Population
Authors: Lübke Christiane 
Published: July 2021

Abstract
Despite the overwhelming scientific consensus, in many Western countries, there appears to be a considerable share of people questioning the existence and anthropogenic cause of climate change. Climate change disbelief includes the absolute rejection of the existence of anthropogenic climate change (climate change denial) as well as a lack of sureness about the anthropogenic cause of climate change (climate change uncertainty). Although considerable research on this phenomenon has been conducted, the roots of climate change disbelief are not yet fully understood. In this article, data from Round 8 of the European Social Survey are used to study the possible socioeconomic roots of climate change disbelief at the individual, regional, and country level. Results show that climate change denial is a marginal phenomenon among European populations but that a great share of people attributes climate change equally to human influences and natural processes. Thereby, it appears that the level of climate change disbelief varies between countries, and even more so between regions within countries. Results of various three-level multilevel models show that socioeconomic factors can partly explain this variation. Individuals who feel insecure about their economic future are significantly more likely to reject the existence of anthropogenic climate change. Furthermore, climate change denial and uncertainty are more common in more rural and less prosperous regions and in countries more economically dependent on fossil fuels. The results contribute to a deeper understanding of climate change disbelief among the European population and have important implications for climate change mitigation efforts.
The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy
Authors: Belhassen Bernard , Laredo Mikael , Roudijk Rob W , Peretto Giovanni , Zahavi Guy , Sen-Chowdhry Srijita , Badenco Nicolas , Te Riele Anneline S J M , Sala Simone , Duthoit Guillaume , van Tintelen J Peter , Paglino Gabriele , Sellal Jean-Marc , Gasperetti Alessio , Arbelo Elena , Andorin Antoine , Ninni Sandro , Rollin Anne , Peichl Petr , Waintraub Xavier , Bosman Laurens P , Pierre Bertrand , Nof Eyal , Miles Chris , Tfelt-Hansen Jacob , Protonotarios Alexandros , Giustetto Carla , Sacher Frederic , Hermida Jean-Sylvain , Havranek Stepan , Calo Leonardo , Casado-Arroyo Ruben , Conte Giulio , Letsas Konstantinos P , Zorio Esther , Bermúdez-Jiménez Francisco J , Behr Elijah R , Beinart Roy , Fauchier Laurent , Kautzner Josef , Maury Philippe , Lacroix Dominique , Probst Vincent , Brugada Josep , Duru Firat , de Chillou Christian , Bella Paolo Della , Gandjbakhch Estelle , Hauer Richard , Milman Anat 
Published: July 2021

Abstract

Aims
In arrhythmogenic cardiomyopathy (ACM), sustained ventricular tachycardia (VT) typically displays a left bundle branch block (LBBB) morphology while a right bundle branch block (RBBB) morphology is rare. The present study assesses the VT morphology in ACM patients with sustained VT and their clinical and genetic characteristics.

Methods and results
Twenty-six centres from 11 European countries provided information on 954 ACM patients who had ≥1 episode of sustained VT spontaneously documented during patients’ clinical course. Arrhythmogenic cardiomyopathy was defined according to the 2010 Task Force Criteria, and VT morphology according to the QRS pattern in V1. Overall, 882 (92.5%) patients displayed LBBB-VT alone and 72 (7.5%) RBBB-VT [alone in 42 (4.4%) or in combination with LBBB-VT in 30 (3.1%)]. Male sex prevalence was 79.3%, 88.1%, and 56.7% in the LBBB-VT, RBBB-VT, and LBBB + RBBB-VT groups, respectively (P = 0.007). First RBBB-VT occurred 5 years after the first LBBB-VT (46.5 ± 14.4 vs 41.1 ± 15.8 years, P = 0.011). An implanted cardioverter-defibrillator was more frequently implanted in the RBBB-VT (92.9%) and the LBBB + RBBB-VT groups (90%) than in the LBBB-VT group (68.1%) (P &lt; 0.001). Mutations in PKP2 predominated in the LBBB-VT (65.2%) and the LBBB + RBBB-VT (41.7%) groups while DSP mutations predominated in the RBBB-VT group (45.5%). By multivariable analysis, female sex was associated with LBBB + RBBB-VT (P = 0.011) while DSP mutations were associated with RBBB-VT (P &lt; 0.001). After a median follow-up of 103 (51–185) months, death occurred in 106 (11.1%) patients with no intergroup difference (P = 0.176).

Conclusion
RBBB-VT accounts for a significant proportion of sustained VTs in ACM. Sex and type of pathogenic mutations were associated with VT type, female sex with LBBB + RBBB-VT, and DSP mutation with RBBB-VT.