bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in cortisol levels by continuous positive airway pressure in patients with obstructive sleep apnoea: Meta‐analysis of 637 individuals
Authors: Ken‐Dror Gie , Fry Christopher H. , Murray Paul , Fluck David , Han Thang S. 
Published: July 2021

AbstractBackgroundObesity, obstructive sleep apnoea (OSA) and hypertension frequently coexist and are associated with elevated cortisol levels. Identification and treatment of such patients is important when investigating for suspected Cushing's syndrome and hypertension. Studies of the impact of continuous positive airway pressure (CPAP) on cortisol and blood pressure are limited by the small sample size and show conflicting findings. We conducted a meta‐analysis to document changes in the levels of cortisol and blood pressure in response to CPAP treatment of OSA.MethodsMeta‐analysis was conducted using RevMan (v5.3) and expressed in standardized mean difference (SMD) for catecholamines and mean difference for systolic (SBP) and diastolic blood pressure (DBP). The quality of the studies was evaluated using standard tools for assessing the risk of bias.ResultsA total of 22 studies met our search criteria; they consisted of 16 prospective cohort studies (PCS) that recruited 385 participants and six randomized control trials (RCT) totalling 252 participants. The range of mean age was 41–62 years and BMI 27.2–35.1 kg/m2. CPAP treatment reduced plasma cortisol levels in PCS: SMD = −0.28 [95% confidence interval (95% CI) = −0.45 to −0.12], I2 = 0%, p = .79 and in RCT: SMD = −0.39 (95% CI = −0.75 to −0.03), I2 = 28.3%, p = .25. CPAP treatment reduced SBP by 5.4 mmHg (95% CI = 1.7–9.1) and DBP by 3.3 mmHg (95% CI = 1.0–5.7). Interstudy heterogeneity was low for all studies. Bias in most RCT arose from the lack of blinding of participants and personnel.ConclusionCPAP treatment in individuals with OSA reduces cortisol levels and blood pressure.
Contrast‐enhanced 3D‐T2‐weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH)‐secreting pituitary microadenomas
Authors: Wu Yue , Cai Yixin , Rui Wenting , Tang Ying , Yang Zhong , He Min , Ye Hongying , Wang Yongfei , Zhao Yao , Ma Zengyi , Yao Zhenwei 
Published: July 2021

AbstractObjectiveCushing disease is a potentially fatal endocrine disorder caused by adrenocorticotropin (ACTH)‐secreting microadenomas in the pituitary gland. Accurate detection and localization of the adenomas is the key to clinical treatment. This study analysed the value of contrast‐enhanced Sampling Perfection with Application‐optimized Contrasts using different flip angle Evolutions (SPACE) sequence in magnetic resonance imaging (MRI) assessment of ACTH‐secreting pituitary microadenomas.Design and PatientsWe carried out a retrospective study in which 45 patients with ACTH‐secreting pituitary microadenomas were enrolled. Dynamic contrast‐enhanced (DCE) coronal T1‐SE sequence was performed. A contrast‐enhanced coronal SPACE sequence was added immediately after DCE MRI finished. Two independent observers assessed the tumour existence and location, then the results were compared with surgical findings.ResultsTwenty‐four lesions (53.3%) were detected by the DCE T1‐SE sequence alone, while 35 lesions (80.0%) were detected with the addition of contrast‐enhanced SPACE sequence. The sensitivity (58.5% vs. 85.3%; p < .05) and best diagnostic accuracy (62.0% vs. 84.4%; p < .05) were significantly better for addition with SPACE sequence than DCE‐SE images alone in detection of ACTH‐secreting pituitary microadenomas. For lesions <5 mm, the detected numbers were 4 (16.6%) versus 10 (27.8%) by DCE T1‐SE sequence and combined DCE T1‐SE with SPACE sequence.ConclusionsA combination of contrast‐enhanced SPACE with DCE T1‐SE sequence could improve the detection of ACTH‐secreting pituitary microadenomas. Contrast‐enhanced SPACE sequence could be a supplementary sequence for imaging of ACTH‐secreting pituitary adenomas when T1‐SE sequence provides negative or equivocal findings.
Reactive dyes for living cells: Applications, artefacts, and some comparisons with textile dyeing
Authors: Horobin Richard W. , Stockert Juan C. , Zhang Hua 
Published: July 2021

AbstractAn inclusive chemical definition of “reactive” dyeing of textiles is introduced, encompassing the CI Azoic, CI Mordant, CI Reactive, CI Sulphur and CI Vat dye application classes. Such reactive dyeing increases fibre retention of dye and makes application practically possible. The analogous application of dyes and fluorescent probes as microscopic stains in biology and medicine is outlined, focussing on using reactive fluorescent probes with living cells. Parallels with textile dyeing are noted, eg, enhanced probe retention and facilitation of probe application. However, the primary purpose of using reactive probes with live cells is detection of properties of biological systems: to identify biological structures and chemical/biochemical contents; assess biological functions and physicochemical properties; and determine changes in locations of cells and cell components. Problems occurring with such probes are outlined, particularly the problematic character of many standard protocols, and localisation artefacts arising with reactive probes whose reactant and product species are physiochemically significantly different. This latter problem is explored via a case study of possible reactant/product artefacts with probes for reactive oxygen species. Comparison of experimental observations of probe localisations with the localisations predicted using quantitative structure activity (QSAR) modelling indicates that such artefacts can occur with a significant proportion of chemically diverse, widely used, commercially available probes, as well as with experimental compounds reported in the literature. A graphical flowchart is provided to assess possible occurrence of reactant/product artefacts arising with reactive fluorescent probes localising in various organelles of living cells.
A supervised learning model to identify the star potential of a basketball player
Authors: Srinivasan Ram , Balasubramanian Venki , Vidyasagar Abhishek 
Published: July 2021

AbstractBasketball is a mathematical game with many abstract data interpretations. An average fan ceases to witness the revolution in sports, which is influenced using data science and analytics unless someone brings it to light. Nowadays, teams look at data and tend to make decisions on scouting the player for the team. The decision making for the coaches can be made easier using machine learning algorithms to identify the star potential of players. The paper provides a novel algorithm by building a machine learning model on all players to predict whether the player is a star or not. Besides, an interactive user interface is developed for coaches to input the player's data and to make an informed decision based on the prediction.
Ester‐linked ubiquitination by HOIL‐1 controls immune signalling by shaping the linear ubiquitin landscape
Authors: Pruneda Jonathan N. , Damgaard Rune Busk 
Published: July 2021

Ester‐linked ubiquitination of serine or threonine residues – or even lipids – has emerged as a new regulatory earmark in cell signalling. Petrova et al. (2021) now reveal that ubiquitin esterification by the atypical ubiquitin ligase HOIL‐1, a component of the LUBAC complex, is critical for proper formation of linear ubiquitin chains and control of immune signalling in T cells and macrophages. Surprisingly, ester‐linked ubiquitination can either promote or inhibit linear ubiquitin conjugation and cytokine production depending on the receptor and immune cell engaged.Comment on: https://doi.org/10.1111/febs.15896.
Hemicrania continua in a family: A report of two cases
Authors: Huang Hao , Newman Lawrence C. 
Published: July 2021

AbstractObjectiveTo report two cases of hemicrania continua (HC) in a mother and daughter.BackgroundHC is a rare primary headache disorder belonging to the family of trigeminal autonomic cephalalgias (TACs). Unlike migraine, familial cases of TACs are rare, and we know relatively little of their inheritance pattern and genetic mechanisms.MethodsWe present a mother and daughter with HC. We compare the similarities and differences between this family and the first report of familial HC and discuss the implications for future studies.ResultsBoth the mother and daughter presented with a constant, side‐locked headache of moderate intensity, with episodic exacerbations of more severe pain that are associated with ipsilateral cranial autonomic activation. After negative workup, both patients were started on indomethacin and achieved absolute response at different doses, confirming HC.ConclusionsOur report further corroborates other reports of familial TACs that TACs are primary headaches possibly attributable to genetic factors, albeit detailed mechanisms remain elusive. Nevertheless, whether clinical presentation and treatment responses would be substantially different between sporadic and familial HCs remain unclear.
Sintering temperature dependency on sodium‐ion conductivity for Na2Zn2TeO6 solid electrolyte
Authors: Itaya Akihiro , Yamamoto Kazuki , Inada Ryoji 
Published: July 2021

AbstractWe investigated the sintering temperature dependency on the properties of Na2Zn2TeO6 (NZTO) solid electrolyte synthesized via a conventional solid‐state reaction method. Sintering temperature of calcined NZTO powder, which was obtained by the calcination of precursor at 850℃, was changed in the range from 650 to 850℃. X‐ray diffraction analysis showed that P2‐type layered NZTO phase was formed in all sintered samples without forming any secondary phases. The relative densities of sintered NZTO samples were approximately 83%−85% for the samples sintered at 700℃ or higher. The all sintered samples showed sodium‐ion conductivity above 10−4 S cm−1 at room temperature and the highest conductivity of 4.0 × 10−4 S cm−1 in the sample sintered at 750℃. The sintering temperature to obtain the highest room temperature conductivity is 100℃ lower than that used in previous works. Such low sintering temperature compared to other Na‐based oxide solid electrolytes could be useful for co‐sintering with electrode active materials for fabrication of all‐solid‐state sodium‐ion battery.
Synthesis of three‐dimensional mesoporous Ni2Fe2N nanocube by micro‐NaCl matrix
Authors: Wu Shengyuan , Choi Hyung Wook , Jeong Dong In , Kim Jiwon , Kang Bong Kyun , Yoon Dae Ho 
Published: July 2021

AbstractIn this study, 3D nanostructured nickel and iron‐based Prussian blue analogue (Ni‐Fe PBA)‐based nitride nanoparticles with uniform morphology and excellent monodispersity were prepared by salt‐matrix annealing method. We tried to let the PBA‐based nitrides maintain the high specific surface area structure with a well‐nitride surface by this method. Unlike Ni‐Fe PBA particles annealed without NaCl, the obtained particles have a similar size as precursors, uniform morphology, and an N‐doped carbon shell covered. The surface area and pore size were calculated to be 94.02 m2g−1 and 3.76 nm.
Polymer‐derived FexSiy/SiC@SiOC ceramic nanocomposites with tunable microwave absorption behavior
Authors: Zhou Cong , Li Shuang , Yu Zhaoju 
Published: July 2021

AbstractIron‐containing PSO precursors (FePSO) were synthesized by modification of polysiloxane with different amounts of ferric acetylacetonate [Fe(acac)3], then porous SiFeCO ceramics were successfully prepared by subsequent pyrolysis. The chemical modification and ceramization process of PFSO precursors were studied by FT‐IR and TGA measurements. XRD patterns imply that the SiC crystalline can be easily observed when PFSO was exposed to 1200℃ in nitrogen atmosphere, while pure PSO exhibited broad diffraction peaks of SiC at 1500℃, meaning that the grain coarsening of SiC was accelerated by adding iron. The crystallization behavior of ferric silicide (FexSiy) is complex due to the variation of iron content in feed and annealing temperature, and FexSiy/SiC@SiOC nanocomposites were produced after annealing. Because of the in‐situ formation of SiC, FexSiy, and carbon strips in nanocomposites, PFSO‐derived ceramics demonstrate enhanced microwave absorption performance. The best effective absorption bandwidth (<−10 dB) and the minimum reflection loss are 2.6 GHz and −38 dB, respectively, which are achieved in the sample PFSO‐3–1300℃. FexSiy/SiC@SiOC nanocomposites synthesized in this work exhibit potential application in the field of electromagnetic interference, the carbon content and the crystallization behavior of FexSiy are the critical factors for the performance optimization.
Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells
Authors: Nalairndran Geetha , Chung Ivy , Abdul Razack Azad Hassan , Chung Felicia Fei‐Lei , Hii Ling‐Wei , Lim Wei‐Meng , Looi Chin King , Mai Chun‐Wai , Leong Chee‐Onn 
Published: July 2021

AbstractProstate cancer (PCa) is the second most common malignancy and is the fifth leading cause of cancer mortality among men globally. Docetaxel‐based therapy remains the first‐line treatment for metastatic castration‐resistant prostate cancer. However, dose‐limiting toxicity including neutropenia, myelosuppression and neurotoxicity is the major reason for docetaxel dose reductions and fewer cycles administered, despite a recent study showing a clear survival benefit with increased total number of docetaxel cycles in PCa patients. Although previous studies have attempted to improve the efficacy and reduce docetaxel toxicity through drug combination, no drug has yet demonstrated improved overall survival in clinical trial, highlighting the challenges of improving the activity of docetaxel monotherapy in PCa. Herein, we identified 15 lethality hits for which inhibition could enhance docetaxel sensitivity in PCa cells via a high‐throughput kinome‐wide loss‐of‐function screen. Further drug‐gene interactions analyses identified Janus kinase 1 (JAK1) as a viable druggable target with existing experimental inhibitors and FDA‐approved drugs. We demonstrated that depletion of endogenous JAK1 enhanced docetaxel‐induced apoptosis in PCa cells. Furthermore, inhibition of JAK1/2 by baricitinib and ruxolitinib synergizes docetaxel sensitivity in both androgen receptor (AR)–negative DU145 and PC3 cells, but not in the AR‐positive LNCaP cells. In contrast, no synergistic effects were observed in cells treated with JAK2‐specific inhibitor, fedratinib, suggesting that the synergistic effects are mainly mediated through JAK1 inhibition. In conclusion, the combination therapy with JAK1 inhibitors and docetaxel could be a useful therapeutic strategy in the treatment of prostate cancers.
Ten‐year questionnaire study on human papillomavirus vaccination targeting new female medical school students: Follow‐up to the 2015 report
Authors: Sukegawa Akiko , Ohshige Kenji , Suzuki Yukio , Mizushima Taichi , Ueda Yutaka , Sekine Masayuki , Enomoto Takayuki , Miyagi Etsuko 
Published: July 2021

AbstractAimWe aimed to conduct a fixed‐point observation questionnaire survey of changes in young women's human papillomavirus (HPV) vaccination status over the course of 10 years. We also investigated the influence of suspension of governmental recommendation for HPV vaccination since June 2013.MethodsDuring 2011–2020, we conducted a self‐completed questionnaire survey among newly enrolled female medical school students in Yokohama, Japan. The questionnaire featured items regarding HPV vaccination status, age, previous sex education, and knowledge about cervical cancer and HPV vaccination.ResultsHPV vaccine uptake rates in 2011 (5.4%) and 2012 (13.5%), when vaccination was self‐funded, increased after 2013 (48.7%), when vaccination fees were subsidized. The rate dropped drastically in 2019 (14.3%) and 2020 (5.1%), after suspension of recommendation by the government. Comparisons between new students in 2015/2016, who had high vaccination rates (65.2%), and new students in 2019/2020, who had low vaccination rates (9.8%), showed decreased levels of HPV vaccination awareness, with fewer students having covered cervical cancer prevention in sex education and with respondents having less knowledge about the details of HPV vaccination.ConclusionsAfter the suspension of proactive HPV vaccine recommendation, markedly fewer students have been vaccinated against HPV, even those at the vaccination target age. This situation has substantially influenced the lower awareness about cervical cancer prevention, even among medical school students. To protect young women from cervical cancer in Japan, it is crucial for the government to resume proactive recommendation of HPV vaccines as soon as possible.
Effect of systemic atherosclerosis on overactive bladder symptoms in men with benign prostatic hyperplasia
Authors: Lee Dongu , Koo Kyo Chul , Yoo Jeong Woo , Lee Kwang Suk 
Published: July 2021

AbstractObjectiveSymptoms of male overactive bladder (OAB) may be caused by several systemic pathophysiological factors rather than a single‐source etiology. We investigated the clinical factors associated with the severity of OAB symptoms in treatment‐naïve men with coexisting benign prostatic hyperplasia.MethodsWe obtained records from a health promotion center database of male patients who visited between March 2019 and February 2020. Men without a history of treatment for lower urinary tract symptoms were evaluated using the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score, transrectal ultrasonography, medical history, and carotid duplex ultrasound for the evaluation of atherosclerosis. Benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) was defined as an IPSS of eight points or higher. Patients with comorbidities that may affect their voiding function were excluded.ResultsA total of 764 patients were divided into two groups based on their diagnosis: an OAB group and a non‐OAB group. The non‐OAB group consisted of 627 patients (82.1%) and the OAB group consisted of 137 patients (17.9%). Using multivariable analysis BPH/LUTS was identified as an independent risk factor for OAB. In the OAB group without BPH/LUTS, carotid atherosclerosis was significantly associated with the severity of OAB symptoms. A history of diabetes mellitus was the only variable that was associated with the severity of urinary urgency. Systolic blood pressure was associated with severity of urinary urgency in the OAB group with BPH/LUTS.ConclusionsFactors associated with male OAB exhibit different pathophysiology in the severity of symptoms depending on the presence of BPH/LUTS. Treatment for atherosclerosis and associated systemic pathophysiological factors could lower OAB symptom severity in male patients without BPH/LUTS.
Acquittal from Knowledge Laundering
Authors: Piñeros Glasscock Juan S. 
Published: July 2021

AbstractSubject‐sensitive invariantism (SSI), the view that whether a subject knows depends on the practical stakes, has been charged with ‘knowledge laundering’: together with widely held knowledge‐transmission principles, SSI appears to allow improper knowledge acquisition. I argue that this objection fails because it depends on faulty versions of transmission principles that would raise problems for any view. When transmission principles are properly understood, they are shown to be compatible with SSI because they do not give rise to improper knowledge acquisition. The upshot is a better understanding of the nature and structure of these transmission principles.
Acute lymphoblastic leukemia in infants: A quarter century of nationwide efforts in Japan
Authors: Tomizawa Daisuke , Miyamura Takako , Koh Katsuyoshi , Ishii Eiichi 
Published: July 2021

AbstractAcute lymphoblastic leukemia (ALL) with KMT2A gene rearrangement (KMT2A‐r) in infants is a biologically and clinically unique disease and one of the most difficult to cure forms of pediatric leukemia. Multicenter clinical trials have been carried out in Japan since the mid‐1990s by introducing allogeneic hematopoietic stem cell transplantation (HSCT) in first remission, which led to a modest improvement in outcome of infants with KMT2A‐r ALL. Because of the emerging evidence that HSCT does not benefit every infant with KMT2A‐r ALL, the Japanese Pediatric Leukemia/Lymphoma Study Group trial MLL‐10 introduced risk stratification using age and presence of central nervous system leukemia, and introduced intensive chemotherapy, including high‐dose cytarabine in early consolidation; indication of HSCT was restricted to the patients with high‐risk features. The trial resulted in excellent 3‐year event‐free survival of 66.2% (standard error, 5.6%) and overall survival of 83.9% (standard error, 4.3%) for 75 patients with KMT2A‐r ALL recruited between 2011 and 2015. This Japanese experience and the results of the infant ALL trials worldwide suggest the importance of introducing effective therapy in the early phase of therapy, thus clearing minimal residual disease as rapidly as possible. However, further improvement in outcome is unlikely with conventional treatment approaches. Introduction of biology‐driven novel agents and/or immunotherapies through international collaboration would be key solutions to overcome the disease.
Immunosuppression in solid organ transplant recipients with Covid‐19: More data, but still complicated
Authors: Heldman Madeleine R. , Kates Olivia S. , Fisher Cynthia E. , Limaye Ajit P. 
Published: July 2021

Abstract“Outcomes of COVID‐19 in solid organ transplant (SOT) recipients: a matched cohort study” by Pereira et al found similar 28 day mortality among hospitalized SOT recipients and comorbidity matched controls, shedding light on the relationship between immunosuppression and Covid‐19 outcomes.
Influence of preanalytical factors on feline proteinuria
Authors: Giraldi Marco , Paltrinieri Saverio , Rossi Gabriele , Ruggerone Beatrice , Zambarbieri Jari , Ercolani Ambra , Scarpa Paola 
Published: July 2021

AbstractBackgroundTo date, little information is available about the effect of preanalytical factors on the urinary protein‐to‐creatinine (UPC) ratio in cats.ObjectivesWe aimed to evaluate the effect of a commercially available cat litter, creatinine measurements at three different dilutions of urine, and different storage conditions on the UPC ratio in cats.MethodsFeline urine specimens were prospectively collected. Twenty‐two whole‐urine specimens were placed uncovered and in contact with cat litter for 1 hour; 25 urine supernatants were diluted 1:10, 1:20, and 1:100 for creatinine measurements. The correlation, difference, agreement, and concordance in classifying specimens according to International Renal Interest Society staging were determined. Storage effects on UPC ratios were assessed in specimens stored for 6 hours at +20℃ (n = 20), 1 week at +4℃ (n = 20), and 3 months at −20℃ (n = 25). Specimens were also subjected to four freeze‐thaw cycles (n = 20). Results were compared, and clinical significance was assessed by comparing each UPC ratio to the inter‐assay range of the baseline value.ResultsExposure to cat litter did not affect UPC ratios. A positive proportional bias was found in the 1:100 dilution compared with the 1:20 dilution; however, concordance was high for all comparisons. At +20, +4℃, and after four repeated freeze‐thaw cycles, UPC ratios were stable. Compared with baseline values, UPC ratios decreased (P < .01) after 8 and 12 weeks at −20℃. However, all UPC ratios were within the inter‐assay variability of the baseline value.ConclusionsExposure to cat litter did not affect UPC ratios, but further studies are necessary to evaluate other potential variables. The effects of the dilutions and storage conditions were clinically acceptable, although the 1:20 and 1:100 dilutions were not perfectly comparable.