bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of 18F-fluorodeoxyglucose-PET/MRI versus MRI alone in the diagnosis of pelvic recurrence of rectal cancer
Authors: Plodeck Verena , Platzek Ivan , Streitzig Johannes , Nebelung Heiner , Blum Sophia , Kühn Jens-Peter , Hoffmann Ralf-Thorsten , Laniado Michael , Michler Enrico , Hoberück Sebastian , Zöphel Klaus , Kotzerke Jörg , Fritzmann Johannes , Weitz Jürgen , Radosa Christoph G. 
Published: August 2021

Abstract
Purpose
To compare the diagnostic performance of 18F-fluorodeoxyglucose-PET/MRI and MRI in the diagnosis of pelvic recurrence of rectal cancer.

Methods
All PET/MRIs of patients in the follow-up of rectal cancer performed between 2011 and 2018 at our institution were retrospectively reviewed. Recurrence was confirmed/excluded either by histopathology or imaging follow-up (> 4 months). Four groups of readers (groups 1/2: one radiologist each, groups 3/4: one radiologist/one nuclear medicine physician) independently interpreted MRI and PET/MRI. The likelihood of recurrence was scored on a 5-point-scale. Inter-reader agreement, sensitivity, specificity, PPV/NPV and accuracy were assessed. ROC curve analyses were performed.

Results
Fourty-one PET/MRIs of 40 patients (mean 61 years ± 10.9; 11 women, 29 men) were included. Sensitivity of PET/MRI in detecting recurrence was 94%, specificity 88%, PPV/NPV 97% and 78%, accuracy 93%. Sensitivity of MRI was 88%, specificity 75%, PPV/NPV 94% and 60%, accuracy 85%. ROC curve analyses showed an AUC of 0.97 for PET/MRI and 0.92 for MRI, but the difference was not statistically significant (p = 0.116). On MRI more cases were scored as equivocal (12% versus 5%). Inter-reader agreement was substantial for PET/MRI and MRI (0.723 and 0.656, respectively).

Conclusion
18F-FDG-PET/MRI and MRI are accurate in the diagnosis of locally recurrent rectal cancer. Sensitivity, specificity, PPV, NPV and accuracy are comparable for both modalities, but PET/MRI increases readers’ confidence levels and reduces the number of equivocal cases.

Graphic abstract
Appropriateness of hip osteoarthritis management in clinical practice compared with the American Academy of Orthopaedic Surgeons (AAOS) criteria
Authors: Alkaramany Eslam , Murshid Abdullah , Alhaneedi Ghalib Ahmed 
Published: August 2021

Abstract
Purpose
The American Academy of Orthopaedic Surgeons (AAOS) developed the appropriate use criteria (AUC) for the management of hip osteoarthritis (OA) to guide surgeons in making decisions based on the best available evidence. This study aimed to assess the applicability of the AUC by comparing the actual treatment provided at our institution with the AUC recommendations.

Methods
A retrospective review of 115 patients who were diagnosed and treated for hip OA at our institution between December 2017 and December 2019 was performed. Data were collected and entered into the AUC application to determine the rate of appropriateness of the provided treatment according to the AUC recommendations. Then, the actual provided treatments were compared with the AUC recommendations to determine the agreement between the two.

Results
There were 115 patients, with a mean age of 50.08 years (range, 30–80 years). The most frequent patient characteristics were middle age (40–65 years) with function-limiting pain at moderate to long distances, minimal hip OA on X-ray examination, mild range of motion limitation, and presence of modifiable risk factors for negative outcomes. The overall rate of appropriateness and in agreement with the AUC recommendations was 100% for conservative treatments and 80.1% for surgical treatments.

Conclusions
This study shows that the majority of the hip OA treatments provided at our institution were appropriate and in agreement with the AUC recommendations. Furthermore, the AUC can be easily accessed through a free web application using a computer or smartphone to obtain the recommended treatment for any patient with hip OA.
Allo-suckling occurrence and its effect on lactation and nursing duration in harbour seals (Phoca vitulina) in Orkney, Scotland
Authors: Arso Civil Mònica , Hague Emily , Langley Izzy , Scott-Hayward Lindesay 
Published: August 2021

AbstractFostering and allo-suckling are widespread among pinnipeds, and several hypotheses have been formulated to explain their occurrence. Here, we describe the occurrence of allo-suckling in harbour seals from photo-identification data of females and pups in Orkney (Scotland) during the pupping seasons between 2016 and 2019. We used a generalised linear model framework to investigate the effect of allo-suckling on the duration of lactation (females) and of nursing period (pups). A generalised additive model framework was used to explore how the probability of allo-suckling varied throughout the pupping season, and with changes in mother-pup separation time. Allo-suckling was observed in 31 females, at higher rates (18–37% of lactating females and 18–47% of the pups every year) than those observed in other phocid populations, with 13 females allo-suckling in multiple years. The duration of the pups’ nursing period was not affected by allo-suckling occurrence. However, females in mother-pup pairs where both mother and pup allo-suckled had longer lactation duration than when only the pup allo-suckled, or than in pairs where no allo-suckling was observed. The probability of allo-suckling increased during the pupping season and with increased mother-pup separation time. However, the proximate causes and the consequences on future reproductive output and pup survival remain unknown.Significance statementAllo-suckling, where females nurse others’ young, is widespread in pinnipeds, particularly among true seals. Given the high costs of lactation in pinnipeds, allo-suckling is a puzzling behaviour. Using photo-identification and field observations, we examined the occurrence of allo-suckling in harbour seals at a colony in Orkney, Scotland. We found that allo-suckling is common among seals at the study site, and at rates higher than reported elsewhere. Our results show that allo-suckling does not appear to affect the duration of the pups’ nursing period but does increase the lactation duration of females who suckle other pups and whose own pups also allo-suckle. This study highlights an area which requires further investigation as the energetic costs and benefits of allo-suckling remain poorly understood.
Short- and long-term outcomes after heart transplantation in cardiac sarcoidosis and giant-cell myocarditis: a systematic review and meta-analysis
Authors: Bobbio Emanuele , Björkenstam Marie , Nwaru Bright I. , Giallauria Francesco , Hessman Eva , Bergh Niklas , Polte Christian L. , Lehtonen Jukka , Karason Kristjan , Bollano Entela 
Published: August 2021

AbstractHeart transplantation (HTx) is a valid therapeutic option for end-stage heart failure secondary to cardiac sarcoidosis (CS) or giant-cell myocarditis (GCM). However, post-HTx outcomes in patients with inflammatory cardiomyopathy (ICM) have been poorly investigated. We searched PubMed, Scopus, Science Citation Index, EMBASE, and Google Scholar, screened the gray literature, and contacted experts in the field. We included studies comparing post-HTx survival, acute cellular rejection, and disease recurrence in patients with and without ICM. Data were synthesized by a random‐effects meta‐analysis. We screened 11,933 articles, of which 14 were considered eligible. In a pooled analysis, post-HTx survival was higher in CS than non-CS patients after 1 year (risk ratio [RR] 0.88, 95% confidence interval [CI] 0.60–1.17; I2 = 0%) and 5 years (RR 0.72, 95% CI 0.52–0.91; I2 = 0%), but statistically significant only after 5 years. During the first-year post-HTx, the risk of acute cellular rejection was similar for patients with and without CS, but after 5 years, it was lower in those with CS (RR 0.38, 95% CI 0.03–0.72; I2 = 0%). No difference in post-HTx survival was observed between patients with and without GCM after 1 year (RR 1.16, 95% CI 0.05–2.28; I2 = 0%) or 5 years (RR 0.98, 95% CI 0.42–1.54; I2 = 0%). During post-HTx follow-up, recurrence of CS and GCM occurred in 5% and 8% of patients, respectively. Post-HTx outcomes in patients with CS and GCM are comparable with cardiac recipients with other heart failure etiologies. Patients with ICM should not be disqualified from HTx.
Graphic abstract
Identifying falls remotely in people with multiple sclerosis
Authors: Block Valerie J. , Pitsch Erica A. , Gopal Arpita , Zhao Chao , Pletcher Mark J. , Marcus Gregory M. , Olgin Jeffrey E. , Hollenbach Jill , Bove Riley , Cree Bruce A. C. , Gelfand Jeffrey M. 
Published: August 2021

Abstract
Background
Falling is common in people with multiple sclerosis (MS) but tends to be under-ascertained and under-treated.

Objective
To evaluate fall risk in people with MS.

Methods
Ninety-four people with MS, able to walk > 2 min with or without an assistive device (Expanded Disability Status Scale (EDSS ≤ 6.5) were recruited. Clinic-based measures were recorded at baseline and 1 year. Patient-reported outcomes (PROs), including a fall survey and the MS Walking Scale (MSWS-12), were completed at baseline, 1.5, 3, 6, 9, and 12 months. Average daily step counts (STEPS) were recorded using a wrist-worn accelerometer.

Results
50/94 participants (53.2%) reported falling at least once. Only 56% of participants who reported a fall on research questionnaires had medical-record documented falls. Fallers had greater disability [median EDSS 5.5 (IQR 4.0–6.0) versus 2.5 (IQR 1.5–4.0), p < 0.001], were more likely to have progressive MS (p = 0.003), and took fewer STEPS (mean difference − 1,979, p = 0.007) than Non-Fallers. Stepwise regression revealed MSWS-12 as a major predictor of future falls.

Conclusions
Falling is common in people with MS, under-reported, and under-ascertained by neurologists in clinic. Multimodal fall screening in clinic and remotely may help improve patient care by identifying those at greatest risk, allowing for timely intervention and referral to specialized physical rehabilitation.
Drug-eluting bead trans-arterial chemoembolization combined with microwave ablation therapy vs. microwave ablation alone for early stage hepatocellular carcinoma: a preliminary investigation of clinical value
Authors: Liu Juanfang , Zhang Wenguang , Lu Huibin , Li Hongbin , Zhou Xueliang , Li Jing , Han Xinwei 
Published: August 2021

Abstract
Purpose
To assess the clinical value of drug-eluting bead trans-arterial chemoembolization (DEB-TACE) combined with microwave ablation (MWA) vs. MWA treatment alone for early stage hepatocellular carcinoma (HCC).

Materials and methods
Consecutive data from 102 HCC patients at early stage who were referred to our hospital from December 2014 to May 2016 were retrospectively collected. Forty-seven patients underwent DEB-TACE combined with MWA treatment, whereas 55 patients underwent MWA alone. After 1 month of treatment, the tumour responses of the patients were assessed using the mRECIST criteria. Treatment-related complications and hepatic function were also analysed for the two groups. In addition, overall survival (OS) and progression-free survival (PFS) were calculated and compared.

Results
Patients in the combined treatment group (DEB-TACE combined with MWA) presented a better objective response rate (ORR) and disease control rate (DCR) compared with those in the monotherapy group (MWA treatment). The median OS and PFS were longer in the combined treatment group compared with the monotherapy group. Multivariate Cox’s regression further illustrated that DEB-TACE + MWA vs. MWA was an independent protective factor for PFS and OS. No serious treatment-related complications were observed in any of the patients.

Conclusion
Combined treatment with DEB-TACE appeared to have advantages in prolonging OS and PFS compared to MWA. Therefore, combined treatment was efficient and should be strongly recommended to early stage HCC patients.
Poisson limit of bumping routes in the Robinson–Schensted correspondence
Authors: Marciniak Mikołaj , Maślanka Łukasz , Śniady Piotr 
Published: August 2021

AbstractWe consider the Robinson–Schensted–Knuth algorithm applied to a random input and investigate the shape of the bumping route (in the vicinity of the y-axis) when a specified number is inserted into a large Plancherel-distributed random tableau. We show that after a projective change of the coordinate system the bumping route converges in distribution to the Poisson process.
Is diversity harmful?—Mixed-brand cardiac implantable electronic devices undergoing magnetic resonance imaging
Authors: König Christoph Alexander , Tinhofer Florian , Puntus Thomas , Burger Achim Leo , Neubauer Nikolaus , Langenberger Herbert , Huber Kurt , Nürnberg Michael , Zweiker David 
Published: August 2021

Summary
Background
Many patients with cardiac implantable electronic devices (CIED) undergo magnetic resonance imaging (MRI); however, a relevant proportion have a CIED system that has not been classified as MRI-conditional because of generators and leads from different brands (mixed-brand group). The available data concerning the outcome of these mixed patients undergoing MRI is limited.

Methods
A retrospective single center study, including all patients with CIEDs undergoing MRI between January 2013 until May 2020, was performed. Primary endpoints were defined as death or any adverse event necessitating hospitalization or CIED revision. Secondary endpoints were the occurrence of any sign for beginning device or lead failure or patient discomfort during MRI.

Results
A total of 227 MRI examinations, including 10 thoracic MRIs, were carried out in 158 patients, with 1–9 MRIs per patient. Of the patients 38 underwent 54 procedures in the mixed-brand group and 89 patients underwent 134 MRIs in the MRI-conditional group. Of the patients 31 were excluded since the MRI conditionality could not be determined. No primary endpoints occurred within the mixed-brand group but in 2.2% of the MRI-conditional group (p = 1.000), with 2 patients developing new atrial fibrillation during MRI, of whom one additionally had a transient CIED dysfunction. No secondary endpoints were met in the mixed-brand group compared to 3.4% in the MRI-conditional group (p = 0.554). No complications occurred in the excluded patients.

Conclusion
The complication rate of CIED patients undergoing MRI was low. Patients with a mixed CIED system showed no signs of increased risk of adverse events compared to patients with MRI-conditional CIED systems.
Comparison of Observations and Predictions of Daytime Planetary-Boundary-Layer Heights and Surface Meteorological Variables in the Columbia River Gorge and Basin During the Second Wind Forecast Improvement Project
Authors: Bianco Laura , Muradyan P. , Djalalova I. , Wilczak J. M. , Olson J. B. , Kenyon J. S. , Kotamarthi R. , Lantz K. , Long C. N. , Turner D. D. 
Published: August 2021

AbstractThe second Wind Forecast Improvement Project (WFIP2) is an 18-month field campaign in the Pacific Northwest U.S.A., whose goal is to improve the accuracy of numerical-weather-prediction forecasts in complex terrain. The WFIP2 campaign involved the deployment of a large suite of in situ and remote sensing instrumentation, including eight 915-MHz wind-profiling radars, and surface meteorological stations. The evolution and annual variability of the daytime convective planetary-boundary-layer (PBL) height is investigated using the wind-profiling radars. Three models with different horizontal grid spacing are evaluated: the Rapid Refresh, the High-Resolution Rapid Refresh, and its nested version. The results are used to assess errors in the prediction of PBL height within the experimental and control versions of the models, with the experimental versions including changes and additions to the model parametrizations developed during the field campaign, and the control version using the parametrizations present in the National Oceanic and Atmospheric Administration/National Centers for Environmental Prediction operational version of the models at the start of the project. Results show that the high-resolution models outperform the low-resolution versions, the experimental versions perform better compared with the control versions, model PBL height estimations are more accurate on cloud-free days, and model estimates of the PBL height growth rate are more accurate than model estimates of the rate of decay. Finally, using surface sensors, we assess surface meteorological variables, finding improved surface irradiance and, to a lesser extent, improved 2-m temperature in the experimental version of the model.
Unequal Conditions of Care and the Implications for Social Policies on Young Carers
Authors: Alexander Chloe 
Published: August 2021

AbstractYoung carers are the subject of public policies in the UK, which aim to address their needs as a group experiencing disadvantage relating to their caring role. These policies are implemented in a way that aims to improve their health and their educational and social opportunities, but left unaddressed is a wider context of inequalities. Nevertheless, inequalities are a feature of the terrain upon which social policies for young carers are developed and implemented. Evaluation of the ways that young carers and their families are impacted by public policies demands an understanding of those inequalities. Academic knowledge of how experiences diverge as a result of multiple intersecting inequalities is so far limited. This paper reports from a study that aimed to contribute greater understanding of the interaction between inequalities, young carers, family life and social policies in England. Ethnographic research methods created a record of care, family life and the impact of social policies. Unequal conditions of care are an important feature of the lives of young people and their families with on-going caring responsibilities. Young carers and their families positioned at the intersection of inequalities of ‘race’/ethnicity, class and disability had different and unequal experiences of support. The paper discusses these findings and explores the implications for social policies and social work practice.
Alliance Between Therapist and Multi-stressed Families During the COVID-19 Pandemic: The Effect of Family-Based Videoconferencing
Authors: Lange Aurelie. M. C. , Delsing Marc J. M. H. , van Geffen Marieke , Scholte Ron. H. J. 
Published: August 2021

Abstract
Background
A strong therapeutic alliance or working relationship is essential for effective face-to-face family-based psychotherapy. However, little is known about the use of VC on alliance in family-based therapy. The recent COVID-19 pandemic led to a national lockdown during which most family-based therapy transferred to VC.

Objective
The current study analyzed the development and strength of alliance prior and during lockdown for multi-stressed families participating in Multisystemic Therapy (MST).

Method
Alliance with the therapist was reported monthly by 846 caregivers (81% female). Using latent growth curve models (longitudinal approach), the development of alliance was estimated for families participating in MST prior to the lockdown, transferring to VC early in treatment or late in treatment. Using regression analyses (cross-sectional approach), lockdown (yes/no) was included as predictor of alliance. In these analyses, type of family (regular; intellectual disability; concerns regarding child abuse or neglect) and gender of caregiver were included as moderators.

Results
Both analytical approaches showed that alliance was not affected by VC, except for families with concerns of child abuse, who reported lower alliances during lockdown. However, these results where no longer significant when controlling for multiple testing.

Conclusions
Strong alliances can be developed and maintained during family-based VC sessions with multi-stressed families. However, for some subgroups, such as families with concerns of child abuse, VC might not be suitable or sufficient. Future research needs to investigate the potential and limitations of using VC with families.
An integrable model for first-order three-planet mean motion resonances
Authors: Petit Antoine C. 
Published: August 2021

AbstractRecent works on three-planet mean motion resonances (MMRs) have highlighted their importance for understanding the details of the dynamics of planet formation and evolution. While the dynamics of two-planet MMRs are well understood and approximately described by a one-degree-of-freedom Hamiltonian, little is known of the exact dynamics of three-body resonances besides the cases of zeroth-order MMRs or when one of the bodies is a test particle. In this work, I propose the first general integrable model for first-order three-planet mean motion resonances. I show that one can generalize the strategy proposed in the two-planet case to obtain a one-degree-of-freedom Hamiltonian. The dynamics of these resonances are governed by the second fundamental model of resonance. The model is valid for any mass ratio between the planets and for every first-order resonance. I show the agreement of the analytical model with numerical simulations. As examples of application, I show how this model could improve our understanding of the capture into MMRs as well as their role in the stability of planetary systems.
Combining Motherhood and Work: Effects of Dual Identity and Identity Conflict on Well-Being
Authors: Zagefka Hanna , Houston Diane , Duff Leonie , Moftizadeh Nali 
Published: August 2021

AbstractThis study investigated whether having a dual identity as both a mother and an employed person constitutes a threat to well-being, or whether it is a positive resource. The study focused on indices of life satisfaction and self-esteem. A convenience sample of 208 mothers were exposed to a manipulation of identity conflict, whereby we manipulated whether working mothers perceived their identities as a mother and an employed person to be in conflict with each other or not. It was hypothesized that generally having multiple identities (as an employee and a mother) would be positively associated with well-being, that perceived identity conflict would have a negative impact on well-being, and that identity conflict would exacerbate the negative effects of identity-related stressors on well-being. Results supported these predictions. The applied implication is that policies that enable mothers to work will be conducive to maternal well-being, but that the policies must minimize conflict between demands associated with employment and parental responsibilities.