bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS HUKUM E-LITIGASI JO. PERMA NOMOR 1 TAHUN 2019 TENTANG ADMINISTRASI PERKARA DAN PERSIDANGAN DI PENGADILAN SECARA ELEKTRONIK DIHUBUNGKAN DENGAN UNDANG-UNDANG NOMOR 7 TAHUN 1989 JO. UNDANG-UNDANG NOMOR 3 TAHUN 2006 JO. UNDANG-UNDANG NOMOR 50 TAHUN 2009 TENTANG PENGADILAN AGAMA
Authors: Annisa Annisa 
Published: June 2021

Penelitian ini memiliki tujuan untuk memaparkan berkenaan dengan analisi hukum e-litigasi. Persidangan dengan e-litigasi yang dasar hukumnya berupa PERMA Nomor 1 Tahun 2019 dianggap telah melampaui hukum acara yang termuat dalam Undang-Undang Nomor 7 Tahun 1989 jo. Undang-Undang Nomor 3 Tahun 2006 jo. Undang-Undang Nomor 50 Tahun 2009 Tentang Pengadilan Agama. Pnelitian ini membahas kedudukan PERMA dalam hierarki perundang-undangan agar dapat diketahui posisi PERMA dan batasan PERMA dalam menyusun peraturannya.Kata kunci: e-litigasi, PERMA, Hukum This study aims to analyze the law of e-litigation. Trials with e-litigation, the legal basis of which is Supreme Court Regulations (PERMA) Number 1 of 2019, are considered to have exceeded the procedural law contained in Law Number 7 of 1989 jo. Law Number 3 of 2006 jo. Law Number 50 of 2009 concerning Religious Courts. This study discussed the position of PERMA in the hierarchy of legislation in order to find out the position of PERMA and the limitations of PERMA in formulating its regulations.Keywords: e-litigation, PERMA, Law
Pengaruh Pemberian Pupuk Limbah Tahu Terhadap Pertumbuhan Dan Hasil Tanaman Kacang Hijau (Vigna radiate L.)
Authors: Sangadji Zulkarnain , Soekamto Mira Herawati , Kayaru Seljun 
Published: June 2021

Tujuan dari penelitian ini adalah Untuk mengetahui pengaruhÂ dan dosis pemberian pupuk limbah cair tahu terhadap pertumbuhan dan hasil tanaman kacang hijau.Â Metode dalam penelitian ini adalah metode eksperimen dengan memggunakan Rancangan Acak Kelompok dengan 4 perlakuan yang terdiriÂ Â dari s0Â (Tanpa Perlakuan), s1 (15 mlÂ Limbah Tahu/tanaman), s2 (30 ml Limbah Tahu /tanaman), s3 Â (45ml limbah Tahu /tanaman) dengan 3 ulangan. Analisis data yang digunakan adalah analisis keragaman ( ANOVA ) yang di lanjutkan dengan uji Beda Nyata Jujur (BNJ) pada tingkat kepercayaannya 0,05%. Hasil dari penelitian ini adalah Pemberian pupuk limbah cair memberikan pengaruh yang nyata pada tinggi tanaman, jumlah daun, jumlah cabang produktif, jumlah biji per polong dan jumlah polong pertanaman, tetapi pada bobot 100 biji tidak menunjukkan pengaruh yang nyata. Perlakuan Dosis 45 ml limbah cair tahu/tanaman menghasilkan rata-rata tertinggiÂ pada umur 1,2,3 dan 4 MST pada tinggi tanaman, jumlah daun, jumlah cabang produktif, jumlah biji per polong, jumlah polong per tanaman dan bobot 100 biji.
Etnobotani Masyarakat Dalam Pemanfaatan Serat Kulit Melinjo Sebagai Bahan Baku Pembuatan Noken Di Kampung Esyo Distrik Aifat Kabupaten Maybrat
Authors: Maruapey Azis , Ponisri Ponisri , Ohorella Syarif 
Published: June 2021

Tas rajutan tangan rakyat Papua, Noken, telah resmi masuk dalam daftar UNESCO warisan budaya. Pengakuan UNESCO akan mendorong upaya melindungi dan mengembangkan warisan budaya Noken. Inskripsi UNESCO ini membuat kami melakukan penelitian etnobotani pembuatan Noken oleh masyarakat di Kampung Esyo Distrik Aifat Kabupaten Maybrat Provinsi Papua Barat.Tujuan penelitian ini untuk mengetahui etnobotani dan pengetahuan lokal (local knouwledge) masyarakat dalam memanfaatkan serat kulit pohon Melinjo, proses dan kriteria pengambilan bahan baku serta proses pembuatan Noken oleh masyarakat di Kampung Esyo Distrik Aifat Kabupaten Maybrat. Â Metode yang digunakan penelitian ini adalah metode deskriptif dengan teknik survey dan wawancara semi struktural (semi structural interview). Data dianalisis secara deskriptif berdasarkan etnobotani pemanfaatan serat kulit pohon Melinjo dan disajikan dalam bentuk gambar.Hasil menunjukkan bahwa pemanfaatan serat kulit pohon Melinjo untuk pembuatan Noken oleh masyarakat Kampung Esyo ,,,,,â€™Distrik Aifat Kabupaten Maybrat, dengan memanfaatkan serat kulit pohon Melinjo dengan ukuran diameter antara 10 - 20 cm. Proses pengambilan serat dengan cara ditebang dan menguliti pohon tersebut. Perlakuan bahan baku melalui perendaman, penjemuran, penghalusan dan pewarnaan dengan maksud agar serat kulit kayu tidak cepat rusak dan lebih tahan lama (awet). Proses pembuatan Noken mengikuti pola sulaman dan anyaman, yang disesuaikan dengan pola dan ukuran Noken yang diinginkan. Pemberian warna Noken memakai pewarna alami dengan memanfaatkan beberapa jenis tumbuhan anggrek alam. Proses perajutan Noken dilakukan pada saat santai atau istirahat, tempat perajitan Noken bisa di rumah, pasar atau tempat pertemuan di kampung.
Sodium-Glucose Cotransporter-2 Inhibitors Ameliorate Liver Enzyme Abnormalities in Korean Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
Authors: Euh Won , Lim Soo , Kim Jin-Wook 
Published: June 2021

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are reported to reduce body fat in patients with type 2 diabetes mellitus (T2DM), and SGLT2i-induced weight reduction may help improve comorbid nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the potential benefit of SGLT2is over other oral antidiabetic drugs (OADs) in patients with T2DM-associated NAFLD. We enrolled real-world Korean patients with T2DM-associated NAFLD in whom initial metformin therapy had been modified by stepwise addition of OAD(s) due to insufficient glucose control. Propensity score (PS) matching was used for the comparison of changes in clinical and biochemical parameters to balance potential covariates. Among the 765 enrolled patients, 663 patients received additional OADs other than SGLT2i and 102 patients received SGLT2i therapy. PS matching selected 150 and 100 patients from the control and the SGLT2i group, respectively. The SGLT2i group lost more weight than the control group at 6 months (mean –1.3 kg vs. 0.0 kg; P &lt; 0.001). Alanine aminotransferase (ALT) levels also decreased more in the SGLT2i group at 3 (–11 U/L vs. –1 U/L), 6 (–12 U/L vs. –1 U/L), and 12 months (–14 U/L vs. –2 U/L) (all P &lt; 0.05). Addition of SGLT2is was an independent predictor of ALT improvement in a multivariate logistic regression model (odds ratio 1.91; P = 0.016). Compared with other OADs, addition of SGLT2is was more effective in weight reduction and ALT improvement in patients with T2DM and comorbid NAFLD.
Predictive Performance of Serum β-hCG MoM Levels for Preeclampsia Screening: A Meta-Analysis
Authors: Zhang Xiao , Huangfu Zhao , Shi Fangxin , Xiao Zhen 
Published: June 2021

ObjectiveThe aim of the present study was to investigate the predictive value of using the multiple of the median (MoM) of β-human chorionic gonadotropin (β-hCG) levels in patients with preeclampsia (PE) and healthy pregnant women.MethodsElectronic databases including PubMed, EBSCO, Ovid, Web of Science, China National Knowledge Infrastructure (CNKI), SinoMed, Wangfang and the Weipu Journal were searched up to May 31, 2020. Two reviewers independently selected the articles and extracted data on study characteristics, quality and results. A random-effects model was employed, and standardized mean difference and 95% confidence intervals were calculated. Twenty-one case-control studies were analyzed in the present meta-analysis, including a total of 2,266 cases and 25,872 healthy controls.ResultsWomen who were diagnosed with PE were found to have higher early second-trimester levels of serum β-hCG MoM compared with healthy controls, although the levels in the first trimester were not significantly different. Ethnicity subgroup analysis demonstrated that the MoM of β-hCG serum levels was significantly higher in PE patients in both Asian and Caucasian populations during the early second trimester.ConclusionThe MoM of β-hCG serum levels was found to be a valuable clinical indicator for predicting PE in the early second trimester, but had little predictive value in the first trimester. However, further assessment of the predictive capacity of β-hCG within larger, diverse populations is required.
Exploring Experiences Responding to the Individual Level Abortion Stigma Scale: Methodological Considerations From In-depth Interviews
Authors: Wollum Alexandra , Makleff Shelly , Baum Sarah E. 
Published: June 2021

Background: The Individual-Level Abortion Stigma (ILAS) scale is a tool to measure multiple dimensions of stigma among people who have abortions. Despite use of the scale globally, little is known about participant experiences completing the scale. We assessed reactions to and experiences with the scale among women who obtained abortions in Mexico, exploring how the items made them feel about themselves and their abortion.Methods: We conducted 10 in-depth interviews with women approximately 6 months after their abortion. We explored experiences answering the ILAS overall as well as each sub-scale (self-judgement; worries about judgement; isolation; community condemnation). We used thematic analysis to examine overall experiences with the ILAS and framework analysis to summarize responses by sub-scale.Results: Many respondents reported positive experiences responding to the scale or said it served a therapeutic purpose. Other participants said the scale caused strong or mixed emotions or generated doubts. Women generally described mixed and negative reactions to the “worries about judgement” and “community condemnation” sub-scales, and more neutral or positive reactions to the “isolation” and “self judgement” sub-scales. Nearly all respondents hypothesized that completing the ILAS at the time of their abortion would be more difficult than responding months after their abortion.Conclusions: People can experience both positive and negative effects when responding to abortion stigma scales. Use of the scales may cause discomfort and introduce concepts that further perpetuate stigma. This study highlights the importance of carefully considering when it is appropriate to implement the scale and exploring safeguards for participants.
A Muscle-Invasive Bladder Cancer Patient With High Tumor Mutational Burden and RB1 Mutation Achieved Bladder Preservation Following Chemotherapy Combined With Immunotherapy: A Case Report
Authors: Cao Chuanzhen , Fu Zhichao , Liu Yueping , Zhou Aiping , Wang Jianfei , Shou Jianzhong 
Published: June 2021

Neoadjuvant chemotherapy followed by radical cystectomy is the standard of care for patients diagnosed with muscle-invasive bladder cancer (MIBC). However, urinary diversion following radical cystectomy significantly reduces patient quality of life. In addition, patients who significantly respond to neoadjuvant chemotherapy have a strong will to preserve the bladder. Bladder-sparing therapy has become a research focus worldwide. Although the bladder-sparing regimen, referred to as trimodality therapy (TMT), has been accepted, the efficacy of immunotherapy combined with chemotherapy for bladder preservation in patients with MIBC has not yet been published. We describe the case of a 50-year-old male presented intermittent macrohematuria and was diagnosed with bladder urothelial carcinoma by diagnostic transurethral resection of bladder tumor (TURBt) with clinical stage IIIA (cT3bN0M0). A complete response was achieved after four courses of neoadjuvant chemotherapy combined with pembrolizumab. Then, we performed a second TURBt plus randomized biopsy by cystoscopy. The pathology indicated no tumor in the bladder. Adjuvant chemoradiotherapy and immunotherapy were subsequently performed. Imaging examinations, cystoscopy and urine tumor DNA (utDNA) levels were used for surveillance after treatment. Finally, the patient achieved bladder preservation and had remained cancer-free for 19 months at the last follow-up on February 20, 2021. This is the first published case study to describe neoadjuvant chemotherapy plus pembrolizumab followed by concurrent chemoradiotherapy as a novel bladder-sparing regimen and successfully achieved a promising outcome.
Thermodynamic Analysis for Binding of 4-O-β-tri-N-acetylchitotriosyl Moranoline, a Transition State Analogue Inhibitor for Hen Egg White Lysozyme
Authors: Ogata Makoto , Fukamizo Tamo , Ohnuma Takayuki 
Published: June 2021

4-O-β-tri-N-acetylchitotriosyl moranoline (GN3M) is a transition-state analogue for hen egg white lysozyme (HEWL) and identified as the most potent inhibitor till date. Isothermal titration calorimetry experiments provided the thermodynamic parameters for binding of GN3M to HEWL and revealed that the binding is driven by a favorable enthalpy change (ΔH° = −11.0 kcal/mol) with an entropic penalty (−TΔS° = 2.6 kcal/mol), resulting in a free energy change (ΔG°) of −8.4 kcal/mol [Ogata et al. (2013) 288, 6,072–6,082]. Dissection of the entropic term showed that a favorable solvation entropy change (−TΔSsolv° = −9.2 kcal/mol) is its sole contributor. The change in heat capacity (ΔCp°) for the binding of GN3M was determined to be −120.2 cal/K·mol. These results indicate that the bound water molecules play a crucial role in the tight interaction between GN3M and HEWL.
Treatment of Unruptured Vertebral Artery Aneurysm Involving Posterior Inferior Cerebellar Artery With Pipeline Embolization Device
Authors: Fu Weiqi , Ge Huijian , Luo Gang , Meng Xiangyu , Wang Jiejun , Jin Hengwei , Li Youxiang 
Published: June 2021

Background: Treatment of unruptured vertebral artery aneurysm involving posterior inferior cerebellar artery (PICA) is challenging. The experience of pipeline embolization device (PED) therapy for these lesions is still limited.Objective: To evaluate the safety and efficacy of the PED for unruptured vertebral artery aneurysm involving PICA.Methods: Thirty-two patients with unruptured vertebral artery aneurysm involving PICA underwent treatment with PED were retrospectively identified. Procedure-related complications, PICA patency, clinical, and angiographic outcomes were analyzed.Results: Thirty-two aneurysms were successfully treated without any procedure-related complications. Images were available in 30 patients (93.8%) during a period of 3–26 months follow-up (average 8.4 months), which confirmed complete occlusion in 17 patients (56.5%), near-complete occlusion in 9 patients (30%), and incomplete occlusion in one patient (3.3%). Parent artery occlusion (PAO) was occurred in 3 patients (10%). Twenty-eight of 30 PICA remained patent. The two occlusions of PICA were secondary to PAO. At a mean of 20.7 months (range 7–50 months) clinical follow-up, all the patients achieved a favorable outcome without any new neurological deficit.Conclusion: PED seems to be a safe and effective alternative endovascular option for patients with unruptured vertebral artery aneurysm involving PICA.
PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells
Authors: Bi Fangfang , An Yuanyuan , Sun Tianshui , You Yue , Yang Qing 
Published: June 2021

BackgroundPlatinum-based chemotherapy is the first line option for ovarian cancer. The development of resistance to such chemotherapy results in treatment failure, while the underlying mechanisms are poorly understood.MethodsClinical samples were collected from Shengjing Hospital of China Medical University. MTT assay was used to see the proliferation and chemoresistance of ovarian cancer cells. Transwell migration and Matrigel invasion assays was used to see the invasion ability of ovarian cancer cells. In addition, polysome profiling and tissue microarray and immunohistochemical staining were also used. The statistical significance of the difference was analyzed by ANOVA and post hoc Dunnett’s test.ResultsPHGDH is the first enzyme responsible for serine biosynthesis pathway. The current study demonstrated that PHGDH is upregulated in platin-resistant ovarian cancer cells and tissues at the protein level. Importantly, knockdown of PHGDH suppressed, while overexpression of PHGDH increased the survival upon cisplatin exposure, invasiveness and spheroid formation of ovarian cancer cells. The current study demonstrated that PHGDH translation was upregulated in platin-resistant ovarian cancer. In addition, our study provided evidence that LncRNA RMRP (RNA Component of Mitochondrial RNA Processing Endoribonuclease) was upregulated in platin-resistant ovarian cancer, which promoted enrichment of RNA binding protein DDX3X (DEAD-Box Helicase 3 X-Linked) on the PHGDH mRNA to promote its translation.ConclusionCollectively, the current study described that PHGDH was upregulated and conferred resistance of ovarian cancer cells to cisplatin, suggesting that cisplatin resistance could be overcome by targeting PHGDH. Our study also provided evidence that differential PHGDH protein expression was defined by its translation, and RNA binding protein DDX3X and LncRNA RMRP are regulators of its translation.
A Novel Mice Model for Studying the Efficacy and IRAEs of Anti-CTLA4 Targeted Immunotherapy
Authors: Xu Shengchao , Yan Xi , Dai Gan , Luo Chengke 
Published: June 2021

BackgroundPatient-derived orthotopic xenograft (PDOX) is a popular animal model for translational cancer research. Immunotherapy is a promising therapy against glioblastoma (GBM). However, the PDOX model is limited to evaluating immune-related events. Our study aims to establish GBM humanized PDOX (HPDOX) mice models to study the mechanism of anti-CTLA4 immunotherapy and immune-related adverse events (IRAEs).MethodsHPDOX models were established by culturing GBM tissues and intracranially implanting them in NSG mice. Meanwhile, peripheral blood mononuclear cells (PBMCs) were separated from peripheral blood and of GBM patients and administrated in corresponding mice. The population of CD45+, CD3+, CD4+, CD8+, and regulatory T (Treg) cells was estimated in the peripheral blood or tumor.ResultsT cells derived from GBM patients were detected in HPDOX mice models. The application of anti-CTLA4 antibodies (ipilimumab and tremelimumab) significantly inhibited the growth of GBM xenografts in mice. Moreover, residual patient T cells were detected in the tumor microenvironment and peripheral blood of HPDOX mice and were significantly elevated by ipilimumab and tremelimumab. Additionally, Treg cells were decreased in mice with IRAEs. Lastly, the proportion of CD4+/CD8+ T cells dramatically increased after the administration of ipilimumab. And the degree of IRAEs may be related to CD56+ expression in HPDOX.ConclusionsOur study established HPDOX mice models for investigating the mechanism and IRAEs of immunotherapies in GBM, which would offer a promising platform for evaluating the efficacy and IRAEs of novel therapies and exploring personalized therapeutic strategies.
Immunonutritive Scoring in Patients With Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: Prognostic Nutritional Index or Controlling Nutritional Status Score?
Authors: Müller Lukas , Hahn Felix , Mähringer-Kunz Aline , Stoehr Fabian , Gairing Simon J. , Foerster Friedrich , Weinmann Arndt , Galle Peter R. , Mittler Jens , Pinto dos Santos Daniel , Pitton Michael B. , Düber Christoph , Kloeckner Roman 
Published: June 2021

ObjectivesThe Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) score are immunonutritive scoring systems with proven predictive ability in various cancer entities, including hepatocellular carcinoma (HCC). We performed the first evaluation of the CONUT score for patients undergoing transarterial chemoembolization (TACE) and compared CONUT and PNI in the ability to predict median overall survival (OS).MethodsBetween 2010 and 2020, we retrospectively identified 237 treatment-naïve patients with HCC who underwent initial TACE at our institution. Both scores include the albumin level and total lymphocyte count. The CONUT additionally includes the cholesterol level. Both scores were compared in univariate and multivariate regression analyses taking into account established risk factors. In a second step, a subgroup analysis was performed on BCLC stage B patients, for whom TACE is the recommended first-line treatment.ResultsA high CONUT score and low PNI were associated with impaired median OS (8.7 vs. 22.3 months, p&lt;0.001 and 6.8 vs. 20.1 months, p&lt;0.001, respectively). In multivariate analysis, only the PNI remained an independent prognostic predictor (p=0.003), whereas the CONUT score lost its predictive ability (p=0.201). In the subgroup of recommended TACE candidates, both CONUT and PNI were able to stratify patients according to their median OS (6.6 vs. 17.9 months, p&lt;0.001 and 10.3 vs. 22.0 months, p&lt;0.001, respectively). Again, in the multivariate analysis, only the PNI remained an independent prognostic factor (p=0.012).ConclusionBoth scores were able to stratify patients according to their median OS, but only the PNI remained an independent prognostic factor. Therefore, PNI should be preferred when evaluating the nutritional status of patients undergoing TACE.
Clinical Characteristics of Paediatric Pancreatitis Caused by Pancreaticobiliary Malformation: A Single-Centre Retrospective Analysis
Authors: Guo Jing , Jia Qian-ru , Sun Mei 
Published: June 2021

Background/Aims: To investigate the clinical profiles of children with pancreatitis caused by pancreaticobiliary malformation.Methods: We retrospectively analysed the clinical data of children diagnosed with pancreatitis at our institute from June 2017 to January 2021.Results: A total of 195 patients and 169 control subjects were included in this study. Twenty-six (13.3%) patients had pancreaticobiliary malformation-related pancreatitis. The average age of onset in the pancreaticobiliary malformation pancreatitis (PMP) group was lower than that in the non-PMP group, and the difference was statistically significant. The number of patients in the PMP group that had jaundice was significantly higher than that of the non-PMP group (P &lt; 0.05). Logistic regression analysis showed that total bilirubin (TB) and γ-glutamyltransferase (GGT) (odds ratio = 1.096, P &lt; 0.01) were independent predictors of pancreaticobiliary malformation-related pancreatitis in children. The positive detection rate of pancreaticobiliary malformation was 68% for abdominal ultrasound, 38.4% for abdominal enhanced computed tomography, and 91.3% for magnetic resonance cholangiopancreatography (MRCP). The recurrence rate (34.6%) in the PMP group was higher than that in the non-PMP group (15.4%, P &lt; 0.05); surgical therapy had the lowest recurrence rate. Age at initial onset of pancreatitis was younger and the period to recurrence was shorter in the PMP group than in the non-PMP group (P &lt; 0.05).Conclusion: Pancreaticobiliary malformation is one of the major causes of paediatric pancreatitis. Elevated TB and GGT in patients with pancreatitis may be suggestive for underlying pancreaticobiliary malformation not solely to pancreatitis. MRCP should be used when pancreatitis due to pancreaticobiliary malformation is suspected. Surgery or endoscopic retrograde cholangiopancreatography-guided intervention may be helpful but further study is needed.