bluuebunny/crossref_metadata_2025_split huggingface dataset:
The (1-x)BiFeO3-xBaTiO3-Bi(Zn0.5Ti0.5)O3 high temperature lead-free piezoelectric ceramics with strong piezoelectric properties
Authors: Sun Yuanyuan , Yang Huabin , Xu Jiwen , Huang Weiran , Jiang Minhong , Chen Qiaohong 
Published: March 2021

Abstract
The structure, microstructure, piezoelectric properties, ferroelectric properties and Curie temperature of (1- x )BiFeO 3 - x BaTiO 3 -Bi(Zn 0.5 Ti 0.5 )O 3 +MnO 2 +Li 2 CO 3 ceramics were investigated experimentally by improved solid-state reaction approach. The crystalline structures were examined by X-ray diffractometry. When x = 0.3, the rhombohedral and pseudocubic phases coexist in the ceramic structure. It is considered that the morphotropic phase boundary was formed here. At the same time, the piezoelectric performance d 33 , Curie temperature T C , and depolarization temperature are as high as 184 pC/N, 550°C, 530°C at x = 0.3, respectively. It is worth noting that when x = 0.24, the ceramics have a high T C = 580°C and low dielectric loss tan δ = 1.9%. These results show that the BFBT-BZT system ceramics are applicable ceramics with high piezoelectric properties in high temperature fields.
Icotinib, an Effective Treatment Option for Patients With Lung Adenocarcinoma Harboring Compound EGFR L858R and A871G Mutation
Authors: Jin Lin-ling , Wu Zhen-zhen , Wang Yan-li , Chen Dong-sheng , Li Si , Xiao Mingzhe , Zhao Xin 
Published: March 2021

Abstract
Compound epidermal growth factor receptor (EGFR) mutations are defined as double or multiple independent mutations of the EGFR tyrosine kinase domain (TKD), in which an EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutation is identified together with a mutation of unclarified clinical significance. Lung adenocarcinoma with compound EGFR mutation shows poor clinical response to EGFR-TKIs. Kobayashi et al. reported a non-small-cell lung cancer (NSCLC) patient whose tumor had EGFR exon21 L858R/A871G mutation presented rapid disease progression to erlotinib. However, in this case, we present an EGFR exon21 L858R/A871G mutation patient exerted significant benefit to icotinib, another first-generation EGFR-TKI, indicating that different EGFR-TKIs have diversiform sensitive sites and therapeutic effects, consistent mutation sites might achieve heterogeneous benefits from different EGFR-TKIs. Our case report provides promising EGFR-TKI for clinical treatment with EGFR exon21 L858R/A871G mutation in NSCLC. More dedicated efforts are needed to clarify their biologic effects on disease course and drug responsiveness.
Different mechanisms underlying divergent responses of autotrophic and heterotrophic respiration to long-term throughfall reduction in a warm-temperate oak forest
Authors: Zhang Jinglei , Liu Shirong , Liu Cuiju , Wang Hui , Luan Junwei , Liu Xiaojing , Guo Xinwei , Niu Baoliang 
Published: March 2021

Abstract
Background: There are many studies on disentangling the responses of autotrophic (AR) and heterotrophic (HR) respiration components of soil respiration (SR) to long-term drought, but few studies have focused on the mechanisms underlying its responses.Methods: To explore the impact of prolonged drought on AR and HR, We conducted the 2-year measurements on soil CO2 effluxes in the 7th and 8th year of manipulated throughfall reduction (TFR) in a warm-temperate oak forest. Results: Our results showed long-term TFR decreased HR, which was positively related to bacterial richness. More importantly, some bacterial taxa such as Novosphingobium and norank Acidimicrobiia, and fungal Leptobacillium were identified as major drivers of HR. In contrast, long-term TFR increased AR due to the increased fine root biomass and production. The increased AR accompanied by decreased HR appeared to counteract each other, and subsequently resulted in the unchanged SR under the TFR. Conclusions: Our study shows that HR and AR respond in the opposite directions to long-term TFR. Soil microorganisms and fine roots account for the respective mechanisms underlying the divergent responses of HR and AR to long-term TFR. This highlights the contrasting responses of AR and HR to prolonged drought should be taken into account when predicting soil CO2 effluxes under future droughts.
Impact of Spatio-Temporal change in landuse/landcover on Groundwater Quality and Human Health; A case study of District Peshawar, Khyber Pakhtunkhwa, Pakistan.
Authors: Ahmad Waqas , Iqbal Javed , Nasir Muhammad Jamal , Ahmad Burhan , Khan Muhammad Tasleem , Khan Shahid Nawaz 
Published: March 2021

Abstract
The quality and quantity of groundwater resources are affected by landuse/landcover (LULC) dynamics, particularly the increasing urbanization coupled with high household wastewater discharge and decreasing open lands. This study evaluates temporal changes of groundwater quality for 2012 and 2019, its relation to Landuse/landcover, and its impact on Peshawar's residents (study area), Pakistan. A total of 105 and 112 groundwater samples were collected from tube wells in 2012 and 2019. Samples were then analyzed for seven standard water quality parameters (i.e., pH, Electric Conductivity (EC), Turbidity, Chloride, Calcium, Magnesium, and Nitrate). Patient data for waterborne diseases were also collected for the years 2012 and 2019 to relate the impact of groundwater quality on human health. Landsat satellite images were classified for the years 2012 and 2019 to observe Landuse/landcover dynamics concerning groundwater quality. Results manifested a decrease in groundwater quality for the year 2019 compared to 2012 and were more highlighted in highly populated areas. The nitrate concentration level was found high in the vicinity of agricultural areas due to the excessive use of nitrogenous fertilizers and pesticides, and thus the methemoglobinemia patients ratio increased by 14% (48- 62% for the year 2012 and 2019, respectively). Besides, Urinary Tract Infections, Peptic Ulcer, and Dental Caries diseases increased due to the high calcium and magnesium concentration. The overall results indicate that anthropogenic activities were the main driver of Spatio-temporal variability in groundwater quality of the study area. The study could help district health administration understand groundwater quality trends, make appropriate site-specific policies, and formulate future health regulations.
The Ontology-Based Modeling and Evolution of Digital Twin for Assembly Workshop
Authors: Bao Qiangwei , Zhao Gang , Yu Yong , Dai Sheng , Wang Wei 
Published: March 2021

Abstract
Digital twin (DT) technology has been entrusted with the tasks of modeling and monitoring of the product, process and production system. Moreover, the development of semantic modeling and digital perception provides the feasibility for the application of DT in the manufacturing industry. However, the application of DT technology in assembly workshop modeling and management is immature for the discreteness of assembly process, diversity of assembly resource and complexity of dataflow in the assembly task execution. A method of ontology-based modeling and evolution of DT for the assembly workshop is proposed to deal with this situation. Firstly, the ontology-based modeling method is given for the assembly resource and process. By instantiating in the ontology, resources and processes can be involved in the modeling and evolution of the DT workshop. Secondly, the DT assembly workshop framework is introduced with the detailed discussions of dataflow mapping, DT evolution, storage and tracing of historical data generated during the operation of the workshop. In addition, a case study is illustrated to show the entire process of construction and evolution of DT modeled on an experimental field, indicating the feasibility and validity of the method proposed.
The Effect of Tool Pin Size and Taper Angle on the Thermal Process and Plastic Material Flow in Friction Stir Welding
Authors: Chen Jie , Shi Lei , Wu Chuansong , Jiang Yuanning 
Published: March 2021

Abstract
Friction stir welding (FSW) tool pin, as a critical component of FSW tool, plays an important role in determining the final joint properties by affecting the heat generation, plastic material flow, welding loads and so on. However, the influence of tool pin on heat and mass transfer in FSW are not elucidated. In the present study, a validated model was adopted to quantitatively analyze the effects of pin size and taper angle on the thermal process and plastic material flow in FSW. It reveals that the torque and transverse force imposed on the pin are increased with the increase of the pin diameters (including its root diameter, its tip diameter and its size in condition of constant taper angle), while the total tool torque various a little for the tool pin diameter considered in this study. When the pin diameters increase, the viscosity of the materials near the pin is decreased, while the temperature as well as the flow velocity is increased. More plastic material near the tool could rotate around the tool with an increase of the pin diameter. The TMAZ boundary is enlarged with larger pin diameters in FSW. Particularly, the shear layer thickness of the same horizontal plane in the range of 1 mm < z < 5 mm is significantly enlarged with an increase of pin root diameters. However, the shear layer thickness of the same horizontal plane in the region of z < 5 mm is increased when using a larger pin tip diameter. In addition, maximum width of TMAZ boundary at the top surface of workpiece was not affected by pin diameters. The model is validated by experimental results. It lays solid foundation for optimizing the tool pin size and taper angle in FSW.
Impacts of ENSO On The Seasonal Transition From Summer to Winter in East Asia
Authors: Kim Sunyong , Kug Jong-Seong 
Published: March 2021

Abstract
The El Niño-Southern Oscillation (ENSO) has seasonally distinct impacts on the East Asian climate so that its seasonal transition depends on the phases of El Niño and La Niña. Here, we investigate the seasonal transition of surface temperature in East Asia from boreal summer to winter based on the warm/cold ENSO developing phases. During La Niña years, from summer to winter the continuous temperature drop in East Asia tends to be faster than that during El Niño, indicating a latter start and earlier termination of fall. This different seasonal transition in East Asia according to phases of ENSO is mostly explained by atmospheric responses to the seasonally-dependent tropical/subtropical precipitation forcings in ENSO developing phases. The anomalous positive precipitation in the subtropical North Pacific exists only in September and leads to the subtropical cyclonic flow during El Niño years. The resultant northerly anomalies on the left side of subtropical cyclone are favorable for transporting cold advection towards East Asia. However, the positive subtropical precipitation disappears and teleconnection to East Asia is strongly controlled by the negative precipitation anomalies in the western North Pacific, modulating the anticyclonic anomalies in East Asia during the early winter (November). Therefore, these seasonally sharp precipitation changes associated with ENSO evolution induce distinctive teleconnection changes from northerly (summer) to southerly (winter) anomalies, which eventually affect seasonal transition in East Asia. Also, the Coupled Model Intercomparison Project Phase 5 models reasonably simulate the relatively rapid temperature transition in East Asia during La Niña years, supporting the observational argument.
Endothelial progenitor cells overexpressed with omentin-1 enhance the inhibition of neointimal hyperplasia via anti-inflammation
Authors: Xiang Yuan , Zhou Zheng-Shi , Li Chuan-Chang , Luo Ying , Zhou Ji Peng 
Published: March 2021

Abstract
Background

Endothelial progenitor cells (EPCs) play an important role in vascular repair. However, the functions of EPCs are obviously weakened in inflammatory microenvironment during restenosis. Therefore, we investigated whether omentin-1, an anti-inflammatory factor, can reduce neointima formation after carotid artery injury (CAI) in rats via improving EPCs functions damaged by inflammation and the underlying mechanisms.
Methods

Rats bone marrow-derived EPCs were isolated and cultured. EPCs were transfected with adenovirus vectors expressing human omentin-1 or green fluorescent protein (GFP). Rats received 2×106 EPCs with expressing omentin-1 or GFP by tail vein injection directly after CAI and again 24 h later. Hematoxylin-eosin staining and immunohistochemistry were used for analyzing neointimal hyperplasia. Besides, EPCs were treated with omentin-1 and tumor necrosis factor-α (TNF-α) in order to explore the underlying mechanism.
Results

Omentin-1 could significantly promote EPCs proliferation and tube formation, as well as inhibit apoptosis. EPCs overexpressed with omentin-1 using adenovirus vectors could extremely reduce the neointimal hyperplasia after CAI in rats. Besides, TNF-α could notably induce EPCs dysfunction including reduced proliferation, migration tube formation and increased apoptosis, which can be remarkably attenuated by omentin-1 via inhibiting of p38/CREB pathway. Besides, p38 agonist (anisomycin) could significantly reverse the protective effects of omentin-1 which attenuated the injury effects of TNF-α on EPCs.
Conclusions

EPCs overexpressed with omentin-1 can significantly reduce neointima formation after arterial injury by enhancing the functions of EPCs via inhibiting the p38/CREB pathway. Our results indicate that gene modified EPCs with omentin-1 may be an alternative strategy for the treatment of restenosis.
Application of Bone Collagen Matrix combined with HUC-MSCs for Alveolar Process Cleft in a Rabbit Model
Authors: Sun Xue-Cheng , Wang Hu , Zhang Dan , Li Jian-Hui , Yin Li-Qiang , Yan Yu-Fang , Ma Xu , Xia Hong-Fei 
Published: March 2021

Abstract
Background: Most materials used clinically for filling severe bone defects lack the ability to induce bone regeneration or low bone conversion rate, therefore, their therapeutic effects are limited. Human umbilical cord mesenchymal stem cells (HUC-MSCs) have good osteoinduction. The mechanism of heterogeneous bone collagen matrix combined with HUC-MSCs in repairing bone defects of alveolar process cleft is still unclear.Methods: Here, a rabbit alveolar process cleft model was established to evaluate the repair effect and molecular mechanism of bone collagen matrix and its combination with HUC-MSCs on critical-sized bone defects in the alveolar process. We randomly divided 48 young Japanese white rabbits (JWRs) into normal, control, material and MSCs groups. The alveolar process cleft model was established by removing the bone of equal volume at the left maxillary. Bone collagen matrix combined with HUC-MSCs that were then implanted in the defect area. X-ray analysis and blood analysis were analyzed 3 months after surgery. Skull tissues were collected for micro-focus computerized tomography (micro-CT) analysis and histochemical staining. The above experiment was repeated 6 months after surgery.Results: the main findingsResults: It was found that bone collagen matrix and HUC-MSCs showed good biocompatibility. Heterogeneous bone collagen matrix combined with HUC-MSCs significantly enhanced osteoinduction and osteoconduction. Conclusions: This experiment provides a new method for repairing alveolar process cleft.Trial registration: Not applicable.
Modeling the occurrence of unsafe behaviors based on dimensions of safety climate and organizational leadership style in oil platforms using fuzzy logic approach
Authors: Yarandi Mohsen Sadeghi , Rastegarzadeh Ehsan , Soltanzadeh Ahmad , Karimi Ali , Panahi Sevda 
Published: March 2021

Abstract
Background: Offshore oil and gas platforms have a high potential for major accidents due to sensitive operational conditions. Safety climate and leadership style have been identified as two key factors in the occurrence of unsafe behaviors. This study aimed to modeling the occurrence of unsafe behaviors based on dimensions of safety climate and organizational leadership style in oil platforms using fuzzy logic approach.Methods: This cross-sectional and modeling study was conducted in 2019 among five oil platforms located in the Persian Gulf. The sample size was 291 employees. To measure organizational leadership style and safety climate, multifactor leadership and standard occupational safety climate questionnaires were used, respectively. To determine unsafe behaviors, a checklist of unsafe acts was used. Data analysis was performed using one-way ANOVA and Pearson correlation coefficients in SPSS version 25. Fuzzy logarithmic model and MATLAB software were used for modeling.Results: There was a significant inverse relationship between transformational and transactional leadership style and the occurrence of unsafe behaviors. Moreover, finding revealed that there was a significant correlation between the dimensions of safety of workplace and the neglecting dangers and the occurrence of unsafe behaviors (P-value< 0.05). The results of the fuzzy logarithmic model also showed that mentioned parameters are important risk factors for predicting the occurrence of unsafe behaviors in oil platforms.Conclusion: Findings revealed that transformational and transactional leadership styles, safety of workplace and neglecting dangers in oil platforms are among important factors in the occurrence of unsafe behaviors. Using fuzzy logarithmic models can also be an effective way to predict and control the occurrence of unsafe behaviors in oil platforms.
Effectiveness of prospective audit-and-feedback intervention in promoting appropriate third-generation cephalosporin use at a tertiary public hospital in Malaysia
Authors: Tan Rou Wei , Thong Kah Shuen , Chang Chee Tao , Cheng Joo Thye , Chan Huan Keat , Cheah Meng Fei 
Published: March 2021

Abstract
Background: Inappropriate use of broad-spectrum antibiotics accelerates the development of drug resistance in nosocomial pathogens. In Malaysia, the National Antimicrobial Guidelines (NAG), along with the feedback from antimicrobial stewardship (AMS) teams, serves as an important guide for antibiotic use in hospitals. Objectives: This study aimed to determine the effectiveness of a prospective audit-and-feedback intervention in promoting the appropriate prescribing of third-generation cephalosporins and timely culture and sensitivity (C&S) testing in patients admitted to a neurosurgical ward. Method: In the pre-intervention phase, a ward pharmacist examined medical records of the patients receiving treatment with third-generation cephalosporins. The use of a cephalosporin was deemed to be appropriate only if it was in line with either the NAG or the recommendations made by the AMS team. The laboratory reports were also checked to see if the C&S testing was performed right before the first dose of a cephalosporin was given. The findings were subsequently presented and discussed in a 2-hour feedback session. The post-intervention audit was performed in the same manner as in the pre-intervention phase. Results: Seventy cases were studied in the pre- and post-intervention phases each. The proportion of cases with appropriate use of third-generation cephalosporin increased significantly from 77.1% (54/70) to 95.8% (67/70) following the intervention (p=0.001). The proportion of cases with a C&S test performed timely also increased significantly from 38.6% (27/70) to 58.6% (41/70) (p=0.018). Conclusion: The prospective audit-and-feedback intervention was effective in improving the appropriateness of the prescribing of third-generation cephalosporins and timely culture and sensitivity testing, indicating the antimicrobial stewardship strategy had produced a positive outcome.
CRISPR/Cas9 mediated T7 RNA polymerase gene knock-in in E. coli BW25113 makes T7 expression system work efficiently
Authors: Ye Changchuan , Chen Xi , Yang Mengjie , Zeng Xiangfang , Qiao Shiyan 
Published: March 2021

Abstract
T7 Expression System is a common method of ensuring tight control and high-level induced expression. However, this system can only work in some bacterial strains in which the T7 RNA Polymerase gene resides in the chromosome. In this study, we successfully introduced a chromosomal copy of the T7 RNA Polymerase gene under control of the lacUV5 promoter into Escherichia coli BW25113. The T7 Expression System worked efficiently in this mutant strain named BW25113-T7. We demonstrated that this mutant strain could satisfactorily produce 5-Aminolevulinic Acid via C5 pathway. A final study was designed to enhance the controllability of T7 Expression System in this mutant strain by constructing a T7 Promoter Variants Library. These efforts advanced E. coli BW25113-T7 to be a practical host for future metabolic engineering efforts.
Piezoelectric Properties of Zinc Oxide/Iron Oxide filled Polyvinylidene fluoride Nanocomposite Fibers
Authors: AlAhzm Abdulrahman Mohmmed , Alejli Maan Omar , Ponnamma Deepalekshmi , Elgawady Yara , Al-Maadeed Mariam Al Ali 
Published: March 2021

Abstract
Piezoelectric nanogenerators (PENG) with flexible and simple design have pronounced significance in fabricating sustainable devices for self-powering electronics. This study demonstrates the fabrication of electrospun nanocomposite fibers from polyvinylidene fluoride (PVDF) filled Zinc Oxide (ZnO)/Iron Oxide (FeO) nanomaterials. The nanocomposite fiber based flexible PENG showed piezoelectric output voltage of 5.9 V when 3 wt.% of ZnO/FeO hybrid nanomaterial was introduced, which was 29.5 times higher than the neat PVDF. No apparent decline in output voltage was observed for almost 2000 seconds attributed to the outstanding durability. This higher piezoelectric output performance is correlated with the β-phase transformation studies from the Fourier transformation infrared spectroscopy and the crystallinity studies from the differential scanning calorimetry. Both these studies show respective enhancement of 3.79 and 2.16 % in the β-phase crystallinity values of PVDF-ZnO/FeO 3 wt.% composite. Higher dielectric constant value obtained for the same composite (3 times higher than the neat PVDF) confirms the increased energy storage efficiency as well. Thus the proposed soft and flexible PENG is a promising mechanical energy harvester, and its good dielectric properties reveals the ability to use this material as good power sources for wearable and flexible electronic devices.