bluuebunny/crossref_metadata_2025_split huggingface dataset:
PANCA WASTA TEACHINGS AS A SOURCE OF INSPIRATION CREATION FOR DHAPUR KRIS
Authors: Nugroho Haris Fajar , Dharsono Dharsono 
Published: December 2021

Panca Wasta is a teaching at the level of family life which contains advice on values that elevate human position in personality, nobility, welfare and knowledge that must be possessed by a man (Javanese) in particular. The focus of the creation of the work is in the form of a kris blade which is inspired by the five elements of the Panca Wasta teachings which contain; wisma, turangga, kukila, curiga and wanita, using recycled metal. The purpose of the creation of this work is to create a dhapur kris blade using recycled metal with a metaphorical tinatah motif from the five elements of the panca wasta teachings. The creation of works uses an artistic creation approach, namely; experiment, contemplation and embodiment of works. The resulting work is a kris blade complete with warangka, hulu/jejeran/ukiran, mendhak, and pendok of Surakarta style. When the teachings of Panca Wasta are used as the concept of creating a kris, it shows that the work of a kris is quite interesting, has aesthetic beauty and full of philosophical values and meanings.
Phenomenologizing the Leadership Practices of the Selected School Heads in the Philippines
Authors: Najera Norma Cordero , Gearlan Amelita A. 
Published: December 2021

Educational leadership has been one of the interesting arguments of many academic researchers over the years. School heads have significant tasks to fulfill as they are responsible for the entire operation of the school as instructional and organizational leaders. In Catholic institutions, school heads are also accountable for the integral formation of the students, as well as the spiritual well-being of faculty and staff, parents and the stakeholder. Most often, they are challenged by various obligations and they need to have strong spirituality in their leadership practices. This qualitative study attempted to describe the leadership practices of a select group of heads of schools run by the Franciscan Sisters of the Sacred Hearts in the Philippines as basis for a proposed leadership formation framework. Thirty (30) heads of schools participated in the study. Among them, six (6) were Principals, six (6) were assistant principals, twelve (12) were academic coordinators and six (6) were heads of different offices. They underwent semi-structured depth interviews. The findings formed “The Whirl of Christ-Centred Leadership Model for Heads of Schools”describes the common practices and the critical instances which make the onset experience, and the value engagements that are observed in the institutions. The findings of this study provides valuable inputs to help school heads to become more inclined and spiritually empowered to influence people, work collaboratively that may result to a progressive and smooth working environment.
Estimasi Ancaman Gempabumi dan Tsunami di Kabupaten Pidie Jaya Aceh untuk Mendukung Keamanan Nasional
Authors: Apriyadi Rio Khoirudin , Kurniawan Wahyu , Yulianto Sugeng , Syamsunasir Syamsunasir , Dewa Ketut Kerta Widana I , Subiyanto Adi , Bahar Fauzi , Cipto Kuncoro Djati 
Published: December 2021

[Estimation of The Threat of Earthquake and Tsunami in Pidie Jaya Regency to Support National Security]. Bencana merupakan suatu ancaman non-militer dan nyata yang dihadapi dunia saat ini. Bencana mengancam keselamatan masyarakat yang pada akhirnya mengancam keamanan nasional suatu negara, termasuk Indonesia. Ancaman nyata yang saat ini dirasakan oleh masyarakat Indonesia adalah peningkatan kejadian bencana yang dirasakan hampir diseluruh wilayah Indonesia. Kabupaten Pidie Jaya yang merupakan bagian dari Provinsi Aceh juga memiliki ancaman multi bencana seperti gempabumi dan tsunami. Gempabumi yang terjadi di Pidie Jaya disebabkan oleh aktivitas Sesar Pidie dengan arah bidang patahan mendatar atau strike-slipe. Selain itu, terdapat Zona Megathrust Sumatera dan Sesar Besar Sumatera yang berada di Provinsi Aceh dengan aktivitas kegempaan yang dapat berpotensi tsunami. Dalam penelitian ini dilakukan suatu simulasi tsunami dengan output wilayah-wilayah yang berpotensi tsunami berserta run up atau ketinggian air tsunami akibat gempa di Zona Megathrust Aceh-Andaman. Penelitian ini menggunakan metode kualitatif (deskriptif analisis) sebagai desain penelitian. Penelitian dilakukan pada 18 Maret 2021 di ruang operasional InaTEWS (Indonesia Tsunami Warning System) Badan Meteorologi, Klimatologi, dan Geofisika (BMKG) menggunakan bantuan software TOAST (Tsunami Observation and Simulation Terminal). Dari seluruh rangkaian pengolahan dan analisis data didapatkan hasil bahwa Zona Megathrust Aceh-Andaman berpotensi tsunami dengan run up (ketinggian air tsunami) yang paling tertinggi sebesar 10,5 meter di Meulaboh, Kab. Aceh Barat, 5,5 meter di Kota Sabang, dan 3 meter di Kabupaten Pidie Jaya dengan waktu tiba tsunami (golden time) sekitar 24 menit 55 detik. Kajian atas estimasi gempabumi dan tsunami ini dapat dijadikan sebagai sumber informasi dalam penentuan kebijakan BPBD Pidie Jaya dalam upaya mitigasi bencana untuk melindungi masyarakat Pidie Jaya dan mewujudkan keamanan nasional.
Development of Articulate Storyline-based Dynamic Fluid Learning Media For Grade XI High School Students
Authors: Fatikhah Farah Faridatul , Anggaryani Mita 
Published: December 2021

Articulate Storyline (AS) is a learning media creation software that presents materials with storylines. The presence of added characters makes the learning media more interactive and more immersed in the story presented. The use of characters is expected to appeal to students learning. The topic used in the learning media developed is Dynamic Fluid. The purpose of this research is to design a physics learning medium that implements Dynamic Fluid theories into a storyline using an Articulate Storyline. According to contextual learning theory, good learning is learning that is applicable to daily life. For further media development, researchers plan to raise the life of a plumber and associate it with Dynamic Fluid materials according to the High School Curriculum. The method used in this study is Research and Development (R&D). Media can be used via web and android. This study stated that the learning media developed is worth using with a validity value of 90.71% classified as very valid. The positive response of students to the media by 99.16%, which belongs to the category, is very good. The percentage of learning activities completed through the comprehension test was 84.4%, which falls into the category of very good. Dynamic fluid learning media based on the Articulate Storyline is suitable for use as a learning resource and as a learning companion for grade 11 high school students.
Neoadjuvant chemotherapy for HER2-positive breast cancer using dose-consolidated regimens and dual anti-HER2 blockade with pertuzumab and trastuzumab (preliminary results)
Authors: Kovalenko E. I. , Artamonova E. V. , Zhulikov Ya. A. , Khoroshilov M. V. 
Published: December 2021

The main goal of neoadjuvant chemotherapy (NACT) in aggressive breast cancer (BC) subtypes (triple-negative, HER2-positive) is to achieve complete pathological response (pCR), since it is associated with a significant decrease in the likelihood of recurrence and death. Currently, the standard approach for HER2+ BC stage II–III is NACT with the inclusion of a double anti-HER2 blockade, since this significantly increases the frequency of pCR. To date, it remains unclear whether the intensification of modern anthracycline-taxane-containing regimens of NACT affects the incidence of pCR in different BC subtypes, including HER2-positive, provided that a double anti-HER2 blockade is used.The aim of our prospective observational study from daily clinical practice was to assess the efficacy (according to the RCB system and the frequency of pCR) and tolerability of dose-dense NACT in stage II–III HER2-positive BC.Materials and methods. The study included 86 patients, mean age 45 years (26–74 years), in 96.5% of cases, the tumor was represented morphologically by invasive cancer of a nonspecific type, in 53.5% of the tumors had a positive luminal B HER2 phenotype, in 46.5% – non-luminal HER2+. The majority of patients (67.4%) had locally advanced inoperable breast cancer; in 80.2% of cases, metastatic lesions of regional lymph nodes were determined. NACT included anthracyclines and taxanes: four cycles of AC in a dose-dense regimen (once every 2 weeks), then four cycles of docetaxel 75 mg/m2 once every 3 weeks + trastuzumab + pertuzumab.Results. The frequency of pCR = RCB0 in the entire group was 54.7% (47/86), in locally advanced breast cancer – 55.9%, in operable breast cancer – 51.9%. In the luminal HER2+ subtype, the frequency of pCR was lower than in the non-luminal HER2+ subtype – 43.5% vs 67.5%, however, the differences were statistically insignificant (p = 0.09). The frequency of RCB0–I in ER+ HER2+ subtype was 60.9%, as in ER-HER2+ – 80%. Conclusions. In our study, for the first time, the efficacy of dose-dense NACT in HER2+ breast cancer was assessed; it was shown that the frequency of pCR and RCB0–I correspond to those in standard anthracycline-taxane-containing regimens. In the context of the use of double anti-HER2 blockade, the anthracycline stage, most likely, does not need to be escalated, since this does not lead to an increase in the frequency of complete pathomorphological regressions.
Conocimiento micológico tradicional en dos comunidades aledañas al Parque Nacional Lagunas de Montebello, Chiapas, México
Authors: Ramírez-Terrazo Amaranta , Montoya Adriana , Kong Alejandro 
Published: December 2021

Antecedentes: El Parque Nacional Lagunas de Montebello es un Área Natural Protegida con alta diversidad biológica y cultural. En el territorio habitan pobladores Chuj y Tojolabales, y son ellos quienes utilizan los hongos. Se tiene poca información sobre el conocimiento maya de los hongos en la zona.
Objetivo: Describir el conocimiento tradicional sobre los hongos en Antelá y Tziscao, Municipio de La Trinitaria.
Métodos: Se realizaron entrevistas dirigidas a los habitantes de ambas comunidades, salidas a diferentes zonas de vegetación para la recolección de hongos y se llevó a cabo la determinación taxonómica de los ejemplares recolectados.
Resultados y conclusiones: En la comunidad de Antelá se conocen 16 especies de hongos y 18 nombres en Tojolabal. En Tziscao conocen 15 especies y 21 nombres en Chuj. Se obtuvo información sobre diferentes aspectos del conocimiento tradicional de los hongos. Hay aspectos de éste (ej. concepto y origen de los hongos, factores para fructificar) que se comparten con otras regiones del país, en la zona se utilizan pocos hongos comparando con los datos de diversidad registrados. Se utilizan hongos tanto de ambientes conservados como de zonas perturbadas. Se recolectó una especie no descrita de hongo (Lactarius aff. deliciosus) conocida localmente como K’anchaya.
Explant Analysis of Utah Electrode Arrays Implanted in Human Cortex for Brain-Computer-Interfaces
Authors: Woeppel Kevin , Hughes Christopher , Herrera Angelica J. , Eles James R. , Tyler-Kabara Elizabeth C. , Gaunt Robert A. , Collinger Jennifer L. , Cui Xinyan Tracy 
Published: December 2021

Brain-computer interfaces are being developed to restore movement for people living with paralysis due to injury or disease. Although the therapeutic potential is great, long-term stability of the interface is critical for widespread clinical implementation. While many factors can affect recording and stimulation performance including electrode material stability and host tissue reaction, these factors have not been investigated in human implants. In this clinical study, we sought to characterize the material integrity and biological tissue encapsulation via explant analysis in an effort to identify factors that influence electrophysiological performance. We examined a total of six Utah arrays explanted from two human participants involved in intracortical BCI studies. Two platinum (Pt) arrays were implanted for 980 days in one participant (P1) and two Pt and two iridium oxide (IrOx) arrays were implanted for 182 days in the second participant (P2). We observed that the recording quality followed a similar trend in all six arrays with an initial increase in peak-to-peak voltage during the first 30–40 days and gradual decline thereafter in P1. Using optical and two-photon microscopy we observed a higher degree of tissue encapsulation on both arrays implanted for longer durations in participant P1. We then used scanning electron microscopy and energy dispersive X-ray spectroscopy to assess material degradation. All measures of material degradation for the Pt arrays were found to be more prominent in the participant with a longer implantation time. Two IrOx arrays were subjected to brief survey stimulations, and one of these arrays showed loss of iridium from most of the stimulated sites. Recording performance appeared to be unaffected by this loss of iridium, suggesting that the adhesion of IrOx coating may have been compromised by the stimulation, but the metal layer did not detach until or after array removal. In summary, both tissue encapsulation and material degradation were more pronounced in the arrays that were implanted for a longer duration. Additionally, these arrays also had lower signal amplitude and impedance. New biomaterial strategies that minimize fibrotic encapsulation and enhance material stability should be developed to achieve high quality recording and stimulation for longer implantation periods.
Inhibition of Neovascularization and Inflammation in a Mouse Model of Corneal Alkali Burns Using Cationic Liposomal Tacrolimus
Authors: Lin Xueqi , Yu Xuewen , Chen Xiang , Sheng Siting , Wang Jingwen , Wang Ben , Xu Wen 
Published: December 2021

Eye drops account for more than 90% of commercialized ophthalmic drugs. However, eye drops have certain shortcomings, such as short precorneal retention time and weak corneal penetration. The requirement of frequent instillation of eye drops also causes poor patient compliance, which may lead to further aggravation of the disease. We aimed to develop a cationic liposome formulation to increase the bioavailability of the therapeutic agent and solve the aforementioned problems. In the present study, we prepared cationic liposomal tacrolimus (FK506) with a surface potential of approximately +30 mV, which could bind to the negatively charged mucin layer of the ocular surface. Our results showed that the content of FK506 in the cornea was increased by 93.77, 120.30, 14.24, and 20.36 times at 5, 30, 60, and 90 min, respectively, in the FK506 liposome group (0.2 mg/ml) compared with the free drug group (0.2 mg/ml). Moreover, FITC-labeled FK506 liposomes significantly prolonged the ocular surface retention time to 50 min after a single dose. In addition, the results of the Cell Counting Kit-8 assay, live and dead cell assay, sodium fluorescein staining, and hematoxylin and eosin staining all indicated that FK506 liposomes had good biological compatibility in both human corneal epithelial cells and mouse eyeballs. Compared with the free drug at the same concentration, FK506 liposomes effectively inhibited vascular endothelial growth factor-induced green fluorescent protein-transduced human umbilical vein endothelial cell migration and tube formation in vitro. In a mouse corneal neovascularization model induced by alkali burns, FK506 liposomes (0.2 mg/ml) enhanced corneal epithelial recovery, inhibited corneal neovascularization, and reduced corneal inflammation, and its therapeutic effect was better than those of the commercial FK506 eye drops (1 mg/ml) and the free drug (0.2 mg/ml). Collectively, these results indicate that cationic FK506 liposomes could increase the efficacy of FK506 in the corneal neovascularization model. Therefore, cationic FK506 liposomes can be considered as a promising ocular drug delivery system.
Poly-Phthalocyanine–Doped Graphene Oxide Nanosheet Conjugates for Electrocatalytic Oxidation of Drug Residues
Authors: Chundu Prince , Dube Edith , Zinyama Ngceboyakwethu P. , Moyo Mambo , Shumba Munyaradzi 
Published: December 2021

Donor and acceptor phthalocyanine molecules were copolymerized and linked to graphene oxide nanosheets through amidation to yield electrocatalytic platforms on glassy carbon electrodes. The platforms were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, UV/Vis spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. The fabricated electrochemical catalytic surfaces were then evaluated toward electrocatalytic detection of ascorbic acid and tryptophan. These were characterized by a wide linear dynamic range and low limits of detection and quantification of 2.13 and 7.12 µM for ascorbic acid and 1.65 and 5.5 µM for tryptophan, respectively. The catalytic rate constant was 1.86 × 104and 1.51 × 104 M−1s−1for ascorbic acid and tryptophan, respectively. The Gibbs energy for catalytic reactions was −17.45 and −14.83 kJ mol−1depicting a spontaneous reaction on the electrode surface. The sensor platform showed an impressive recovery when applied in real samples such as fresh cow milk, in the range 91.71–106.73% for both samples. The developed sensor therefore shows high potential for applicability for minute quantities of the analytes in real biological samples.
A Fast and Easy-To-Go Method for the Preparation of Au Nanocluster and Its Application for Fe(III) Cation Sensing
Authors: Zhu Peibin , Chen Wen , Liu Liang 
Published: December 2021

In this article, we reported the synthesis and characterization of gold nanoclusters (AuNCs) with a diameter of ∼2 nm. A simple method of microwave-assisted reaction was applied here, with L-cysteine as both reducing agent and stabilizer. The resulting AuNCs were analyzed by means of TEM, XPS, DLS, and IR. Their photophysical performance was then analyzed in detail, including UV-vis absorption, emission, quantum yield, and lifetime. Efficient red emission was observed from these AuNCs, originating from ligand-to-metal nanoparticle core charge transfer (LMNCT). This red emission was found quenchable by Fe(III) cations. The corresponding quenching curve and sensing performance were discussed. An effective working region of 0–80 μM with an LOD of 3.9 μM was finally observed. Their quenching mechanism was revealed as Fe(III) energy competing for the LMNCT process. The novelty and advancement of this work is the simple synthesis and impressive sensing performance, including wide working region, good linearity, and selectivity.
Characteristics of Fecal Microbiota and Machine Learning Strategy for Fecal Invasive Biomarkers in Pediatric Inflammatory Bowel Disease
Authors: Wang Xinqiong , Xiao Yuan , Xu Xu , Guo Li , Yu Yi , Li Na , Xu Chundi 
Published: December 2021

BackgroundEarly diagnosis and treatment of pediatric Inflammatory bowel disease (PIBD) is challenging due to the complexity of the disease and lack of disease specific biomarkers. The novel machine learning (ML) technique may be a useful tool to provide a new route for the identification of early biomarkers for the diagnosis of PIBD.MethodsIn total, 66 treatment naive PIBD patients and 27 healthy controls were enrolled as an exploration cohort. Fecal microbiome profiling using 16S rRNA gene sequencing was performed. The correlation between microbiota and inflammatory and nutritional markers was evaluated using Spearman’s correlation. A random forest model was used to set up an ML approach for the diagnosis of PIBD using 1902 markers. A validation cohort including 14 PIBD and 48 irritable bowel syndrome (IBS) was enrolled to further evaluate the sensitivity and accuracy of the model.ResultCompared with healthy subjects, PIBD patients showed a significantly lower diversity of the gut microbiome. The increased Escherichia-Shigella and Enterococcus were positively correlated with inflammatory markers and negatively correlated with nutrition markers, which indicated a more severe disease. A diagnostic ML model was successfully set up for differential diagnosis of PIBD integrating the top 11 OTUs. This diagnostic model showed outstanding performance at differentiating IBD from IBS in an independent validation cohort.ConclusionThe diagnosis penal based on the ML of the gut microbiome may be a favorable tool for the precise diagnosis and treatment of PIBD. A study of the relationship between disease status and the microbiome was an effective way to clarify the pathogenesis of PIBD.
Oral Colonization by Entamoeba gingivalis and Trichomonas tenax: A PCR-Based Study in Health, Gingivitis, and Periodontitis
Authors: Yaseen Alaa , Mahafzah Azmi , Dababseh Deema , Taim Duaa , Hamdan Ahmad A. , Al-Fraihat Esraa , Hassona Yazan , Şahin Gülşen Özkaya , Santi-Rocca Julien , Sallam Malik 
Published: December 2021

BackgroundThe etiology of periodontitis remains unclear, as is the place of gingivitis in its pathophysiology. A few studies linked the colonization by oral parasites (Entamoeba gingivalis and Trichomonas tenax) to periodontal disease and its severity. The aim of the current study was to estimate the prevalence of these oral parasites among healthy individuals, and in patients with gingivitis and periodontitis in Jordan.MethodsThe study was conducted during July 2019–December 2019. Samples were composed of saliva and periodontal material including dental plaque sampled with probes. The detection of oral parasites was done using conventional polymerase chain reaction (PCR).ResultsThe total number of study participants was 237: healthy (n=94), gingivitis (n=53) and periodontitis (n=90). The prevalence of E. gingivalis was 88.9% among the periodontitis patients, 84.9% among the gingivitis patients and 47.9% in the healthy group. For T. tenax, the prevalence was 25.6% among the periodontitis patients, 5.7% among the gingivitis patients and 3.2% in the heathy group. Positivity for E. gingivalis was significantly correlated with the presence of periodontal disease compared to the healthy group with odds ratio (OR) of 6.6. Periodontal disease was also correlated with lower monthly income (OR=8.2), lack of dental care (OR=4.8), and history of diabetes mellitus (OR=4.5). Colonization by E. gingivalis was correlated with gingivitis (OR=6.1) compared to the healthy group. Colonization by E. gingivalis and T. tenax were significantly correlated with periodontitis (OR=6.4 for E. gingivalis, and OR=4.7, for T. tenax) compared to the healthy group. T. tenax was only detected among individuals with generalized periodontal disease compared to its total absence among those with localized disease (19.6% vs. 0.0%; p=0.039). The co-infection rate by the two oral parasites was 11.0%.ConclusionsThe higher prevalence of human oral parasites in periodontal disease compared to healthy individuals appears to be more than a mere marker for the disease and might also be associated with disease severity and potential for progression. Thus, the dogmatic view of E. gingivalis and T. tenax as commensals needs to be re-evaluated and their contribution to pathophysiology of periodontal diseases cannot be neglected.