bluuebunny/crossref_metadata_2025_split huggingface dataset:
National parochialism is ubiquitous across 42 nations around the world
Authors: Romano Angelo , Sutter Matthias , Liu James H. , Yamagishi Toshio , Balliet Daniel 
Published: July 2021

AbstractCooperation within and across borders is of paramount importance for the provision of public goods. Parochialism – the tendency to cooperate more with ingroup than outgroup members – limits contributions to global public goods. National parochialism (i.e., greater cooperation among members of the same nation) could vary across nations and has been hypothesized to be associated with rule of law, exposure to world religions, relational mobility and pathogen stress. We conduct an experiment in participants from 42 nations (N = 18,411), and observe cooperation in a prisoner’s dilemma with ingroup, outgroup, and unidentified partners. We observe that national parochialism is a ubiquitous phenomenon: it is present to a similar degree across the nations studied here, is independent of cultural distance, and occurs both when decisions are private or public. These findings inform existing theories of parochialism and suggest it may be an obstacle to the provision of global public goods.
Bidirectional interconversion of microwave and light with thin-film lithium niobate
Authors: Xu Yuntao , Sayem Ayed Al , Fan Linran , Zou Chang-Ling , Wang Sihao , Cheng Risheng , Fu Wei , Yang Likai , Xu Mingrui , Tang Hong X. 
Published: July 2021

AbstractSuperconducting cavity electro-optics presents a promising route to coherently convert microwave and optical photons and distribute quantum entanglement between superconducting circuits over long-distance. Strong Pockels nonlinearity and high-performance optical cavity are the prerequisites for high conversion efficiency. Thin-film lithium niobate (TFLN) offers these desired characteristics. Despite significant recent progresses, only unidirectional conversion with efficiencies on the order of 10−5 has been realized. In this article, we demonstrate the bidirectional electro-optic conversion in TFLN-superconductor hybrid system, with conversion efficiency improved by more than three orders of magnitude. Our air-clad device architecture boosts the sustainable intracavity pump power at cryogenic temperatures by suppressing the prominent photorefractive effect that limits cryogenic performance of TFLN, and reaches an efficiency of 1.02% (internal efficiency of 15.2%). This work firmly establishes the TFLN-superconductor hybrid EO system as a highly competitive transduction platform for future quantum network applications.
Poor response to neoadjuvant chemotherapy in metaplastic breast carcinoma
Authors: Wong Willard , Brogi Edi , Reis-Filho Jorge S. , Plitas George , Robson Mark , Norton Larry , Morrow Monica , Wen Hannah Y. 
Published: July 2021

AbstractMetaplastic breast carcinoma (MpBC) is a rare special histologic subtype of breast carcinoma characterized by the presence of squamous and/or mesenchymal differentiation. Most MpBCs are of triple-negative phenotype and neoadjuvant chemotherapy (NAC) is frequently utilized in patients with MpBC. The aim of this study was to evaluate response to NAC in a retrospective cohort of MpBCs. We identified 44 patients with MpBC treated with NAC at our center between 2002 and 2018. Median age was 48 years, 86% were clinical stage II–III, and 36% were clinically node-positive. Most (80%) MpBCs were triple-negative or low (1–10%) hormonal receptor positive and HER2 negative on pre-NAC biopsy. While on NAC, 49% showed no clinical response or clinico-radiological progression. Matrix-producing subtype was associated with clinico-radiological response (p = 0.0036). Post NAC, two patients initially ineligible for breast-conserving surgery (BCS) were downstaged to be eligible for BCS, whereas three patients potentially eligible for BCS before treatment became ineligible due to disease progression. Only one (2%) patient had a pathologic complete response (pCR). Among the 16 patients presenting with biopsy-proven clinical node-positive disease, 3 (19%) had nodal pCR. Axillary lymph node dissection was avoided in 3 (19%) patients who had successful axillary downstaging. Residual cancer burden (RCB) was assessed in 22 patients and was significantly associated with disease-free survival and overall survival. We observed a poor response or even disease progression on NAC among patients with MpBC, suggesting that NAC should be reserved for patients with inoperable MpBC.
Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
Authors: Zhang Hongying , Wang Yahong , Zhang Ziyan , Zhang Lu , Tang Chao , Sun Boqun , Jiang Zhihao , Ding Bo , Cai Peng 
Published: July 2021

AbstractThis study aimed to investigate alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity, which was implemented through the random positioning machine, while different light conditions (normal photoperiod and constant dark) were set. Fruit flies of different strains and sexes were treated for 3 days, and activity and sleep were monitored using the Drosophila Activity Monitoring System. After 3 days of treatment, fruit flies were sampled to detect the relative expression levels of the major clock genes and some neurotransmitter-related genes. The results showed that for the normal photoperiod (LD) condition, the activity increased and sleep decreased under simulated microgravity, while for the constant dark (DD) condition, the activity and sleep rhythms appeared disordered and the activity increased, thus decreasing the likelihood of waking up during the day. Light conditions, strains, and sexes, individually or in combination, had impacts on the simulated microgravity effects on behaviors. The clock genes and neurotransmitter-related genes had different degrees of response among sexes and strains, although the overall changes were slight. The results indicated that the normal photoperiod could ease the effects of simulated microgravity on fruit flies’ activity and sleep and possible unidentified pathways involved in the regulatory mechanism need further exploration. This study is expected to provide ideas and references for studying the effects of microgravity on space life science.
Microstructured capacitive sensor with broad detection range and long-term stability for human activity detection
Authors: He Xin , Liu Zhihao , Shen Gengzhe , He Xiang , Liang Jionghong , Zhong Yu , Liang Tianlong , He Jie , Xin Yue , Zhang Chi , Ye Dongdong , Cai Guofa 
Published: July 2021

AbstractIn recent years, flexible stress sensors capable of monitoring diverse body movements and physiological signals have been attracting great attention in the fields of healthcare systems, human–machine interfaces, and wearable electronics. Inspired by the structure of natural eggshell inner membrane (ESIM), we developed a pressure sensor based on MXene (Ti3C2Tx)/Ag NWs (silver nanowires) composite electrodes and the micro-structured dielectric layer to meet the application requirements of wide detection range and long-term stability for the sensors. In the light of the nanoscale-microarray of the dielectric layer and the rough surface of electrode materials, this pressure sensor is expected to allow great and persistent deformation during the loading process. As a result, the device is characterized by an improved sensitivity, fast response (in the millisecond range), wide detection range (0–600 kPa), and long-term stability. The outstanding performance of the proposed sensor makes it possible to detect various human activities, such as speaking, air blowing, clenching, walking, finger/knee/elbow bending, and striking, demonstrating its good application prospects in wearable and flexible electronic devices.
resistancebank.org, an open-access repository for surveys of antimicrobial resistance in animals
Authors: Criscuolo Nicola G. , Pires João , Zhao Cheng , Van Boeckel Thomas P. 
Published: July 2021

AbstractAntimicrobial resistance (AMR) is a growing threat to the health of humans and animals that requires global actions. In high-income countries, surveillance systems helped inform policies to curb AMR in animals. In low- and middle-income countries (LMICs), demand for meat is rising, and developing policies against AMR is urgent. However, surveillance of AMR is at best nascent, and the current evidence base to inform policymakers is geographically heterogeneous. We present resistancebank.org, an online platform that centralizes information on AMR in animals from 1,285 surveys from LMICs. Surveys were conducted between 2000 and 2019 and include 22,403 resistance rates for pathogens isolated from chickens, cattle, sheep, and pigs. The platform is built as a shiny application that provides access to individual surveys, country-level reports, and maps of AMR at 10 × 10 kilometers resolution. The platform is accessed via any internet browser and enables users to upload surveys to strengthen a global database. resistancebank.org aims to be a focal point for sharing AMR data in LMICs and to help international funders prioritize their actions.
Powered flight in hatchling pterosaurs: evidence from wing form and bone strength
Authors: Naish Darren , Witton Mark P. , Martin-Silverstone Elizabeth 
Published: July 2021

AbstractCompeting views exist on the behaviour and lifestyle of pterosaurs during the earliest phases of life. A ‘flap-early’ model proposes that hatchlings were capable of independent life and flapping flight, a ‘fly-late’ model posits that juveniles were not flight capable until 50% of adult size, and a ‘glide-early’ model requires that young juveniles were flight-capable but only able to glide. We test these models by quantifying the flight abilities of very young juvenile pterosaurs via analysis of wing bone strength, wing loading, wingspan and wing aspect ratios, primarily using data from embryonic and hatchling specimens of Pterodaustro guinazui and Sinopterus dongi. We argue that a young Sinopterus specimen has been mischaracterised as a distinct taxon. The humeri of pterosaur juveniles are similar in bending strength to those of adults and able to withstand launch and flight; wing size and wing aspect ratios of young juveniles are also in keeping with powered flight. We therefore reject the ‘fly-late’ and ‘glide-early’ models. We further show that young juveniles were excellent gliders, albeit not reliant on specialist gliding. The wing forms of very young juveniles differ significantly from larger individuals, meaning that variation in speed, manoeuvrability, take-off angle and so on was present across a species as it matured. Juveniles appear to have been adapted for flight in cluttered environments, in contrast to larger, older individuals. We propose on the basis of these conclusions that pterosaur species occupied distinct niches across ontogeny.
The first draft genome of Picrorhiza kurrooa, an endangered medicinal herb from Himalayas
Authors: Sharma Tanvi , Sharma Nitesh Kumar , Kumar Prakash , Panzade Ganesh , Rana Tanuja , Swarnkar Mohit Kumar , Singh Anil Kumar , Singh Dharam , Shankar Ravi , Kumar Sanjay 
Published: July 2021

AbstractPicrorhiza kurrooa is an endangered medicinal herb which is distributed across the Himalayan region at an altitude between 3000–5000 m above mean sea level. The medicinal properties of P. kurrooa are attributed to monoterpenoid picrosides present in leaf, rhizome and root of the plant. However, no genomic information is currently available for P. kurrooa, which limits our understanding about its molecular systems and associated responses. The present study brings the first assembled draft genome of P. kurrooa by using 227 Gb of raw data generated by Illumina and PacBio RS II sequencing platforms. The assembled genome has a size of n = ~ 1.7 Gb with 12,924 scaffolds. Four pronged assembly quality validations studies, including experimentally reported ESTs mapping and directed sequencing of the assembled contigs, confirmed high reliability of the assembly. About 76% of the genome is covered by complex repeats alone. Annotation revealed 24,798 protein coding and 9789 non-coding genes. Using the assembled genome, a total of 710 miRNAs were discovered, many of which were found responsible for molecular response against temperature changes. The miRNAs and targets were validated experimentally. The availability of draft genome sequence will aid in genetic improvement and conservation of P. kurrooa. Also, this study provided an efficient approach for assembling complex genomes while dealing with repeats when regular assemblers failed to progress due to repeats.
Nutrient provision capacity of alternative livestock farming systems per area of arable farmland required
Authors: Lee M. R. F. , Domingues J. P. , McAuliffe G. A. , Tichit M. , Accatino F. , Takahashi T. 
Published: July 2021

AbstractAlthough climate impacts of ruminant agriculture are a major concern worldwide, using policy instruments to force grazing farms out of the livestock industry may diminish opportunities to produce nutritious food without exacerbating the food-feed competition for fertile and accessible land resources. Here, we present a new set of quantitative evidence to demonstrate that, per unit of overall nutrient value supplied by a given commodity, the demand for land suitable for human-edible crop production is considerably smaller under ruminant systems than monogastric systems, and consistently so at both farm and regional scales. We also demonstrate that imposition of a naïvely designed “red meat tax” has the potential to invite socioeconomic losses far greater than its environmental benefits, due largely to the induced misallocation of resources at the national scale. Our results reiterate the risk inherent in an excessively climate-focused debate on the role of livestock in human society and call for more multidimensional approaches of sustainability assessment to draw better-balanced policy packages.
Gut microbiota-generated metabolite, trimethylamine-N-oxide, and subclinical myocardial damage: a multicenter study from Thailand
Authors: Senthong Vichai , Kiatchoosakun Songsak , Wongvipaporn Chaiyasith , Phetcharaburanin Jutarop , Tatsanavivat Pyatat , Sritara Piyamitr , Phrommintikul Arintaya 
Published: July 2021

AbstractPlasma Trimethylamine-N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, is mechanistically linked to cardiovascular disease (CVD) and adverse cardiovascular events. We aimed to examine the relationship between plasma TMAO levels and subclinical myocardial damage using high-sensitivity cardiac troponin-T (hs-cTnT). We studied 134 patients for whom TMAO data were available from the Cohort Of patients at a high Risk of Cardiovascular Events—Thailand (CORE-Thailand) registry, including 123 (92%) patients with established atherosclerotic disease and 11 (8%) with multiple risk factors. Plasma TMAO was measured by NMR spectroscopy. In our study cohort (mean age 64 ± 8.9 years; 61% men), median TMAO was 3.81 μM (interquartile range [IQR] 2.89–5.50 μM), and median hs-cTnT was 15.65 ng/L (IQR 10.17–26.67). Older patients and those with diabetic or hypertension were more likely to have higher TMAO levels. Plasma TMAO levels correlated with those of hs-cTnT (r = 0.54; p < 0.0001) and were significantly higher in patients with subclinical myocardial damage (hs-cTnT ≥ 14 ng/L; 4.48 μM vs 2.98 μM p < 0.0001). After adjusting for traditional risk factors, elevated TMAO levels remained independently associated with subclinical myocardial damage (adjusted odds ratio [OR]: 1.58; 95% CI 1.24–2.08; p = 0.0007). This study demonstrated that plasma TMAO was an independent predictor for subclinical myocardial damage in this study population.
Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes
Authors: Ayra-Plasencia Jessel , Ramos-Pérez Cristina , Santana-Sosa Silvia , Quevedo Oliver , Medina-Suárez Sara , Matos-Perdomo Emiliano , Zamora-Dorta Marcos , Brown Grant W. , Lisby Michael , Machín Félix 
Published: July 2021

AbstractThe key role of Topoisomerase II (Top2) is the removal of topological intertwines between sister chromatids. In yeast, inactivation of Top2 brings about distinct cell cycle responses. In the case of the conditional top2-5 allele, interphase and mitosis progress on schedule but cells suffer from a chromosome segregation catastrophe. We here show that top2-5 chromosomes fail to enter a Pulsed-Field Gel Electrophoresis (PFGE) in the first cell cycle, a behavior traditionally linked to the presence of replication and recombination intermediates. We distinguished two classes of affected chromosomes: the rDNA-bearing chromosome XII, which fails to enter a PFGE at the beginning of S-phase, and all the other chromosomes, which fail at a postreplicative stage. In synchronously cycling cells, this late PFGE retention is observed in anaphase; however, we demonstrate that this behavior is independent of cytokinesis, stabilization of anaphase bridges, spindle pulling forces and, probably, anaphase onset. Strikingly, once the PFGE retention has occurred it becomes refractory to Top2 re-activation. DNA combing, two-dimensional electrophoresis, genetic analyses, and GFP-tagged DNA damage markers suggest that neither recombination intermediates nor unfinished replication account for the postreplicative PFGE shift, which is further supported by the fact that the shift does not trigger the G2/M checkpoint. We propose that the absence of Top2 activity leads to a general chromosome structural/topological change in mitosis.
Agro-economic and socio-environmental assessments of food and virtual water trades of Iran
Authors: Karandish Fatemeh , Nouri Hamideh , Brugnach Marcela 
Published: July 2021

AbstractEnding hunger and ensuring food security are among targets of 2030’s SDGs. While food trade and the embedded (virtual) water (VW) may improve food availability and accessibility for more people all year round, the sustainability and efficiency of food and VW trade needs to be revisited. In this research, we assess the sustainability and efficiency of food and VW trades under two food security scenarios for Iran, a country suffering from an escalating water crisis. These scenarios are (1) Individual Crop Food Security (ICFS), which restricts calorie fulfillment from individual crops and (2) Crop Category Food Security (CCFS), which promotes “eating local” by suggesting food substitution within the crop category. To this end, we simulate the water footprint and VW trades of 27 major crops, within 8 crop categories, in 30 provinces of Iran (2005–2015). We investigate the impacts of these two scenarios on (a) provincial food security (FSp) and exports; (b) sustainable and efficient blue water consumption, and (c) blue VW export. We then test the correlation between agro-economic and socio-environmental indicators and provincial food security. Our results show that most provinces were threatened by unsustainable and inefficient blue water consumption for crop production, particularly in the summertime. This water mismanagement results in 14.41 and 8.45 billion m3 y−1 unsustainable and inefficient blue VW exports under ICFS. “Eating local” improves the FSp value by up to 210% which lessens the unsustainable and inefficient blue VW export from hotspots. As illustrated in the graphical abstract, the FSp value strongly correlates with different agro-economic and socio-environmental indicators, but in different ways. Our findings promote “eating local” besides improving agro-economic and socio-environmental conditions to take transformative steps toward eradicating food insecurity not only in Iran but also in other countries facing water limitations.
Diagnostic accuracy of dual-phase 18F-FP-CIT PET imaging for detection and differential diagnosis of Parkinsonism
Authors: Oh Minyoung , Lee Narae , Kim Chanwoo , Son Hye Joo , Sung Changhwan , Oh Seung Jun , Lee Sang Ju , Chung Sun Ju , Lee Chong Sik , Kim Jae Seung 
Published: July 2021

AbstractDelayed phase 18F-FP-CIT PET (dCIT) can assess the striatal dopamine transporter binding to detect degenerative parkinsonism (DP). Early phase 18F-FP-CIT (eCIT) can assess the regional brain activity for differential diagnosis among parkinsonism similar with 18F-FDG PET. We evaluated the diagnostic performance of dual phase 18F-FP-CIT PET (dual CIT) and 18F-FDG PET compared with clinical diagnosis in 141 subjects [36 with idiopathic Parkinson’s disease (IPD), 77 with multiple system atrophy (MSA), 18 with progressive supranuclear palsy (PSP), and 10 with non-DP)]. Visual assessment of eCIT, dCIT, dual CIT, 18F-FDG and 18F-FDG PET with dCIT was in agreement with the clinical diagnosis in 61.7%, 69.5%, 95.7%, 81.6%, and 97.2% of cases, respectively. ECIT showed about 90% concordance with non-DP and MSA, and 8.3% and 27.8% with IPD and PSP, respectively. DCIT showed ≥ 88% concordance with non-DP, IPD, and PSP, and 49.4% concordance with MSA. Dual CIT showed ≥ 90% concordance in all groups. 18F-FDG PET showed ≥ 90% concordance with non-DP, MSA, and PSP, but only 33.3% concordance with IPD. The combination of 18F-FDG and dCIT yielded ≥ 90% concordance in all groups. Dual CIT may represent a powerful alternative to the combination of 18F-FDG PET and dCIT for differential diagnosis of parkinsonian disorders.
Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
Authors: Kim Gyeonghwa , Han Ja Ryung , Park Soo Young , Tak Won Young , Kweon Young-Oh , Lee Yu Rim , Han Young Seok , Park Jung Gil , Kang Min Kyu , Lee Hye Won , Lee Won Kee , Kim Deokhoon , Jang Se Young , Hur Keun 
Published: July 2021

AbstractCircular RNAs (circRNAs) represent potential biomarkers because of their highly stable structure and robust expression pattern in clinical samples. The aim of this study was to evaluate the expression of a recently identified circRNA, hsa_circ_0005986; determine its clinical significance; and evaluate its potential as a biomarker of hepatocellular carcinoma (HCC). We evaluated hsa_circ_0005986 expression in 123 HCC tissue samples, its clinical significance, and its association with patients’ clinicopathological characteristics and survival. Hsa_circ_0005986 expression was downregulated in HCC tissues. Low hsa_circ_0005986 expression was more common in tumors larger than 5 cm [odds ratio (OR), 3.19; 95% confidence interval (CI), 1.51–6.76; p = 0.002], advanced TNM stage (III/IV; OR, 2.39; 95% CI, 1.16–4.95; p = 0.018), and higher BCLC stage (B/C; OR, 2.71; 95% CI, 1.30–5.65; p = 0.007). High hsa_circ_0005986 expression was associated with improved survival and was an independent prognostic factor for overall [hazard ratio (HR), 0.572; 95% CI, 0.339–0.966; p = 0.037] and progression-free (HR, 0.573; 95% CI, 0.362–0.906; p = 0.017) survival. Moreover, the circRNA–miRNA–mRNA network was constructed using RNA-seq/miRNA-seq data and clinical information from TCGA-LIHC dataset. Our findings indicate a promising role for hsa_circ_0005986 as a prognostic biomarker in patients with HCC.