bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of insulin resistance in obesity: a role of ATP
Authors: Ye Jianping 
Published: May 2021

AbstractObesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively investigated for more than 60 years, but the essential pathogenic signal remains missing. Existing hypotheses include inflammation, mitochondrial dysfunction, hyperinsulinemia, hyperglucagonemia, glucotoxicity, and lipotoxicity. Drug discoveries based on these hypotheses are unsuccessful in the development of new medicines. In this review, multidisciplinary literature is integrated to evaluate ATP as a primary signal for insulin resistance. The ATP production is elevated in insulin-sensitive cells under obese conditions independent of energy demand, which we have named “mitochondrial overheating.” Overheating occurs because of substrate oversupply to mitochondria, leading to extra ATP production. The ATP overproduction contributes to the systemic insulin resistance through several mechanisms, such as inhibition of AMPK, induction of mTOR, hyperinsulinemia, hyperglucagonemia, and mitochondrial dysfunction. Insulin resistance represents a feedback regulation of energy oversupply in cells to control mitochondrial overloading by substrates. Insulin resistance cuts down the substrate uptake to attenuate mitochondrial overloading. The downregulation of the mitochondrial overloading by medicines, bypass surgeries, calorie restriction, and physical exercise leads to insulin sensitization in patients. Therefore, ATP may represent the primary signal of insulin resistance in the cellular protective response to the substrate oversupply. The prevention of ATP overproduction represents a key strategy for insulin sensitization.
The role of FDG PET/CT or PET/MRI in assessing response to neoadjuvant therapy for patients with borderline or resectable pancreatic cancer: a systematic literature review
Authors: Evangelista Laura , Zucchetta Pietro , Moletta Lucia , Serafini Simone , Cassarino Gianluca , Pegoraro Nicola , Bergamo Francesca , Sperti Cosimo , Cecchin Diego 
Published: May 2021

AbstractThe aim of the present systematic review is to examine the role of fluorodeoxyglucose (FDG) positron emission tomography (PET) associated with computed tomography (CT) or magnetic resonance imaging (MRI) in assessing response to preoperative chemotherapy or chemoradiotherapy (CRT) for patients with borderline and resectable pancreatic ductal adenocarcinoma (PDAC). Three researchers ran a database query in PubMed, Web of Science and EMBASE. The total number of patients considered was 488. The most often used parameters of response to therapy were the reductions in the maximum standardized uptake value (SUVmax) or the peak standardized uptake lean mass (SULpeak). Patients whose SUVs were higher at the baseline (before CRT) were associated with a better response to therapy and a better overall survival. SUVs remaining high after neoadjuvant therapy correlated with a poor prognosis. Available data indicate that FDG PET/CT or PET/MRI can be useful for predicting and assessing response to CRT in patients with resectable or borderline PDAC.
The analysis of the operational process of a complex fire alarm system used in transport facilities
Authors: Paś Jacek , Klimczak Tomasz , Rosiński Adam , Stawowy Marek 
Published: May 2021

AbstractA fire alarm system (FAS) is a system comprising signalling-alarm devices, which automatically detect and transmit information about fire, but also receivers of fire alarms and receivers for damage signals. Fire alarm systems function in different environmental conditions. During operation they should be in state of fitness. This is determined by the reliability of the assembled units and rational management of the operation process. Therefore a reliability and operational analysis of fire alarm systems as a whole is essential. This article presents an authorial model and an operational and reliability analysis of FAS, which is exploited in a transport building. It also demonstrates relationships occurring in the analysed system, where to an addressable fire alarm central unit with detection loops and control-monitoring loops alarm device lines (with monitored relay outputs for actuation of alarm-signalling devices) were connected. Research and analysis of results for representative FAS, which were exploited in similar environmental conditions, were conducted in order to determine operational and reliability parameters of the investigated system. FAS computer simulation was run during the time t = 1 year of safety system operation. This led to the calculation of the probability value of the analysed FAS staying in the examined operational states.
Extreme secondary sexual dimorphism in the genus Florarctus (Heterotardigrada: Halechiniscidae)
Authors: Gąsiorek Piotr , Kristensen David Møbjerg , Kristensen Reinhardt Møbjerg 
Published: May 2021

AbstractSecondary sexual dimorphism in florarctin tardigrades is a well-known phenomenon. Males are usually smaller than females, and primary clavae are relatively longer in the former. A new species Florarctus bellahelenae, collected from subtidal coralline sand just behind the reef fringe of Long Island, Chesterfield Reefs (Pacific Ocean), exhibits extreme secondary dimorphism. Males have developed primary clavae that are much thicker and three times longer than those present in females. Furthermore, the male primary clavae have an accordion-like outer structure, whereas primary clavae are smooth in females. Other species of Florarctus Delamare-Deboutteville & Renaud-Mornant, 1965 inhabiting the Pacific Ocean were investigated. Males are typically smaller than females, but males of Florarctus heimi Delamare-Deboutteville & Renaud-Mornant, 1965 and females of Florarctus cervinus Renaud-Mornant, 1987 have never been recorded. The Renaud-Mornant collection was re-examined, and type series were analysed. Florarctus heimi and F. cervinus were always found together in the coralline sand of Heron Island (Great Barrier Reef). The animals were kept alive and surveyed in the laboratory of the Queensland Museum. All studied individuals of the larger F. heimi (up to ca. 400 μm) were females, and all adults of the smaller F. cervinus (about 170 μm) were males. Males of F. cervinus were observed mating with females of F. heimi. Following those morphological and behavioural lines of evidence, we propose that F. cervinus is a junior synonym of F. heimi. Based on the discovery of dimorphism in F. bellahelenae sp. nov. and the strong sex-related morphological disparities in F. heimi, we suggest that extreme secondary dimorphism may be present in other florarctin arthrotardigrades.
Our Voices Matter: Using Lived Experience to Promote Equity in Problem Gambling Prevention
Authors: Ortiz Victor , Cain Rachael , Formica Scott W. , Bishop Rebecca , Hernández Haner , Lama Lorena 
Published: May 2021

AbstractPurpose of ReviewThe field of problem gambling has been historically disconnected from the community experience of gambling and people of color, leading to a lack of integration of those with lived experience into programming. The aim of this article is to describe community-centered efforts to prevent and mitigate harm from problem gambling in Massachusetts—including a pilot program, the Massachusetts Ambassador Project, which is grounded within public health and lived experience frameworks.Recent FindingsTo engage Massachusetts communities in problem gambling prevention, planning processes were conducted to develop culturally appropriate prevention strategies. One of the recurrent themes was the desire of men in the substance misuse recovery community to share their knowledge with others, specifically, men of color who experience racism and health disparities. This finding informed the development of the Ambassador Project, a novel, peer-based, community-centered, and culturally responsive approach for men of color who have a history of substance misuse to engage other men of color in problem gambling prevention.Two organizations pilot tested the project and reached 4388 individuals. The pilot led to several findings in the design and implementation of related projects. Lessons are shared in three categories: structure, support, and implementation.SummaryThis article demonstrates an innovative approach to connect the field of problem gambling prevention to the community experience, using a public health and social justice lens. Others in the field should acknowledge the disconnect between problem gambling and the lived experience of those disproportionately impacted by creating opportunities for community voice to be at the center of programming.
A robust intelligent zero-day cyber-attack detection technique
Authors: Kumar Vikash , Sinha Ditipriya 
Published: May 2021

AbstractWith the introduction of the Internet to the mainstream like e-commerce, online banking, health system and other day-to-day essentials, risk of being exposed to various are increasing exponentially. Zero-day attack(s) targeting unknown vulnerabilities of a software or system opens up further research direction in the field of cyber-attacks. Existing approaches either uses ML/DNN or anomaly-based approach to protect against these attacks. Detecting zero-day attacks through these techniques miss several parameters like frequency of particular byte streams in network traffic and their correlation. Covering attacks that produce lower traffic is difficult through neural network models because it requires higher traffic for correct prediction. This paper proposes a novel robust and intelligent cyber-attack detection model to cover the issues mentioned above using the concept of heavy-hitter and graph technique to detect zero-day attacks. The proposed work consists of two phases (a) Signature generation and (b) Evaluation phase. This model evaluates the performance using generated signatures at the training phase. The result analysis of the proposed zero-day attack detection shows higher performance for accuracy of 91.33% for the binary classification and accuracy of 90.35% for multi-class classification on real-time attack data. The performance against benchmark data set CICIDS18 shows a promising result of 91.62% for binary-class classification on this model. Thus, the proposed approach shows an encouraging result to detect zero-day attacks.
Snakebites Reported to the Kentucky Regional Poison Control Centers for the Years 2012-2016
Authors: Buchanan James , Thurman Jeffrey , Hargis Charles , Kirkpatrick Lauren , Huecker Martin 
Published: May 2021

Introduction Snake envenomations cause significant morbidity and mortality. The goals of this study were to assess the epidemiology of snakebites in Kentucky and treatment strategies used by physicians reporting to the Kentucky Regional Poison Control Centers. Methods This was a descriptive epidemiologic study compiling clinical data on snakebites reported to the Kentucky Regional Poison Control Centers from 2012 to 2016. We built a database of the patient demographics, treatment, and clinical course of each snakebite reported in the study period. Attention was paid to all antivenom interventions and use of contraindicated therapies. Results We compiled 674 total records. Patient age was 34±18 y (mean±SD), with males (71%) predominating. Most (97%) bites were to a distal upper or lower extremity. The majority (78%) occurred at a private residence. Most reports came between May and September (88%). Of the 674 patients, 24% (n=159) were classified as moderate or severe. Two hundred thirty (34%) patients were admitted to the hospital. Forty-six patients (7%) received surgical consultation, and 12 (2%) underwent surgical intervention. One hundred fifty-three patients received antivenom, with 6±3 vials used per patient. Length of stay was 3±2 d when antivenom was administered and 2±2 d when not administered. Six cases of coagulopathy were noted. Multiple contraindicated therapies were noted. Conclusions Snake envenomations are a prevalent public health concern for residents of Kentucky, chiefly during summer months. Significant medical intervention is being performed for many patients, with a high prevalence of contraindicated therapies. More data are needed to fully characterize the epidemiologic impact and appropriateness of the interventions being applied.
Evaluation of Environmental Conditions on Self-Selected Work and Heat Stress in Wildland Firefighting
Authors: Sol Joseph A. , West Molly R. , Domitrovich Joseph W. , Ruby Brent C. 
Published: May 2021

Introduction The purpose of this study was to evaluate heat stress occurring in wildfire management activities with variable environmental conditions. Methods Direct observation and real-time wireless physiological monitoring allowed for weather and physiological metrics, including heart rate, core temperature (Tc), skin temperature, and physiological strain index (PSI), of male (n=193) and female (n=28) wildland firefighters (WLFFs) to be recorded during wildfire management activities. Accelerometry data were used to categorize intensity level of activity. Results Ambient temperature and relative humidity values were used to compute the heat index (HI; n=3891 h) and divided into quartiles (Q1: 13.3–25.1°C; Q2: 25.2–26.4°C; Q3: 26.5–28.9°C; Q4: 29.0–49.1°C). Activity levels remained relatively constant across all HI quartiles. The percentage of time spent performing moderate/vigorous activities was lowest during the hotter Q4 (Q1: 3%; Q2: 2%; Q3: 2%; Q4: 1%). Heart rate, Tc, PSI, and skin temperature associations with HI varied by resource type. Sixty-one percent of WLFFs (n=134) experienced a Tc ≥38.0°C, and 50% of WLFFs (n=111) experienced a PSI ≥6.0. Conclusions Heat stress was prevalent as WLFFs performed job tasks of varying intensities in all ambient conditions. Spontaneous bouts of arduous labor, duration of work shifts, and other occupation characteristics present the possibility for substantial durations of hyperthermia, although no heat-related injuries occurred in this study. Despite chronic exposure to rugged sloped terrain, load carriage, and environmental conditions, self-regulation and individual attention to managing work:rest appears to be the primary management strategy in mitigating excessive accumulation of body heat in this occupation.
From the lab to the poll: The use of survey experiments in political research
Authors: Martini Sergio , Olmastroni Francesco 
Published: May 2021

AbstractThe article offers an overview of the use of survey experiments in political research by relying on available examples, bibliographic data and a content analysis of experimental manuscripts published in leading academic journals over the last two decades. After a short primer to the experimental approach, we discuss the development, applications and potential problems to internal and external validity in survey experimentation. The article also provides original examples, contrasting a traditional factorial and a more innovative conjoint design, to show how survey experiments can be used to test theory on relevant political topics. The main challenges and possibilities encountered in envisaging, planning and implementing survey experiments are examined. The article outlines the merits, limits and implications of the use of the experimental method in political research.
Two decades of digital interventions for anxiety disorders: a systematic review and meta-analysis of treatment effectiveness
Authors: Pauley Darin , Cuijpers Pim , Papola Davide , Miguel Clara , Karyotaki Eirini 
Published: May 2021

Abstract

Background
Digital interventions for anxiety disorders are a promising solution to address barriers to evidence-based treatment access. Precise and powerful estimates of digital intervention effectiveness for anxiety disorders are necessary for further adoption in practice. The present systematic review and meta-analysis examined the effectiveness of digital interventions across all anxiety disorders and specific to each disorder v. wait-list and care-as-usual controls.

Methods
A systematic search of bibliographic databases identified 15 030 abstracts from inception to 1 January 2020. Forty-seven randomized controlled trials (53 comparisons; 4958 participants) contributed to the meta-analysis. Subgroup analyses were conducted by an anxiety disorder, risk of bias, treatment support, recruitment, location and treatment adherence.

Results
A large, pooled effect size of g = 0.80 [95% Confidence Interval: 0.68–0.93] was found in favor of digital interventions. Moderate to large pooled effect sizes favoring digital interventions were found for generalized anxiety disorder (g = 0.62), mixed anxiety samples (g = 0.68), panic disorder with or without agoraphobia (g = 1.08) and social anxiety disorder (g = 0.76) subgroups. No subgroups were significantly different or related to the pooled effect size. Notably, the effects of guided interventions (g = 0.84) and unguided interventions (g = 0.64) were not significantly different. Supplemental analysis comparing digital and face-to-face interventions (9 comparisons; 683 participants) found no significant difference in effect [g = 0.14 favoring digital interventions; Confidence Interval: −0.01 to 0.30].

Conclusion
The precise and powerful estimates found further justify the application of digital interventions for anxiety disorders in place of wait-list or usual care.
A novel methodology to explore the periodic gait of a biped walker under uncertainty using a machine learning algorithm
Authors: Kim Namjung , Jeong Bongwon , Park Kiwon 
Published: May 2021

AbstractIn this paper, we present a systematic approach to improve the understanding of stability and robustness of stability against the external disturbances of a passive biped walker. First, a multi-objective, multi-modal particle swarm optimization (MOMM-PSO) algorithm was employed to suggest the appropriate initial conditions for a given biped walker model to be stable. The MOMM-PSO with ring topology and special crowding distance (SCD) used in this study can find multiple local minima under multiple objective functions by limiting each agent’s search area properly without determining a large number of parameters. Second, the robustness of stability under external disturbances was studied, considering an impact in the angular displacement sampled from the probabilistic distribution. The proposed systematic approach based on MOMM-PSO can find multiple initial conditions that lead the biped walker in the periodic gait, which could not be found by heuristic approaches in previous literature. In addition, the results from the proposed study showed that the robustness of stability might change depending on the location on a limit cycle where immediate angular displacement perturbation occurs. The observations of this study imply that the symmetry of the stable region about the limit cycle will break depending on the accelerating direction of inertia. We believe that the systematic approach developed in this study significantly increased the efficiency of finding the appropriate initial conditions of a given biped walker and the understanding of robustness of stability under the unexpected external disturbance. Furthermore, a novel methodology proposed for biped walkers in the present study may expand our understanding of human locomotion, which in turn may suggest clinical strategies for gait rehabilitation and help develop gait rehabilitation robotics.
Investigation of endophenotype potential of decreased fractional anisotropy in pediatric bipolar disorder patients and unrelated offspring of bipolar disorder patients
Authors: Camkurt Mehmet A. , Melicher Tomas , Mwangi Benson , Wu Mon-Ju , Cao Bo , Zeni Cristian P. , Tannous Jonika , Zunta-Soares Giovana , Hasan Khader , Sanches Marsal , Soares Jair C. 
Published: May 2021

AbstractBackgroundBipolar disorder (BD) is a severe psychiatric disorder associated with structural and functional brain abnormalities, some of which have been found in unaffected relatives as well. In this study, we examined the potential role of decreased fractional anisotropy (FA) as a BD endophenotype, in adolescents at high risk for BD.MethodsWe included 15 offspring of patients with BD, 16 pediatric BD patients, and 16 matched controls. Diffusion weighted scans were obtained on a 3T scanner using an echo-planar sequence. Scans were segmented using FreeSurfer.ResultsOur results showed significantly decreased FA in six brain areas of offspring group; left superior temporal gyrus (LSTG; P < .0001), left transverse temporal gyrus (LTTG; P = .002), left banks of the superior temporal sulcus (LBSTS; P = .002), left anterior cingulum (LAC; P = .003), right temporal pole (RTP; P = .004) and left frontal pole (LFP; P = .017). On analysis, LSTG, LAC, and RTP demonstrated a potential to be an endophenotype when comparing all three groups. FA values in three regions, LBSTS, LTTG, and LFP were increased only in controls.ConclusionOur findings point at decreased FA as a possible endophenotype for BD, as they were found in children of patients with BD. Most of these areas were previously found to have morphological and functional changes in adult and pediatric BD, and are thought to play important roles in affected domains of functioning. Prospective follow up studies should be performed to detect reliability of decreased FA as an endophenotype and effects of treatment on FA.
Anthropometric characteristics of children living in food-insecure households in the USA
Authors: Tayie Francis A , Lambert Lea Anne , Aryeetey Richmond , Xu Beibei , Brewer Gabrielle 
Published: May 2021

AbstractObjective:This study provides information on food insecurity and child malnutrition in a technologically advanced nation.Design:Population-based study using multistage probability cluster sampling design to collect survey data. Multivariable regression models were used to determine associations between food security status and various malnutrition indices.Setting:We used a national sample from the US National Health and Nutrition Examination Survey 2011–2014.Participants:The anthropometric and demographic data sets of 4121 children <7 years old were analysed for this study.Results:Food-insecure infants younger than 6 months had shorter upper arm length (–0·4 cm, P = 0·012) and smaller mid-upper arm circumference (–0·5 cm, P = 0·004); likewise those aged 6 months–1 year had shorter upper arm length (–0·4 cm, P = 0·008), body length (–1·7 cm, P = 0·007) and lower body weight (–0·5 kg, P = 0·008). Food-insecure children younger than 2 years were more likely to be underweight (OR: 4·34; 95 % CI 1·99, 9·46) compared with their food-secure counterparts. Contrariwise, food-insecure children older than 5 years were more likely to be obese (OR: 3·12; 95 % CI 1·23, 7·96).Conclusions:Food insecurity associates with child growth deficits in the USA. Food-insecure infants and young children are generally smaller and shorter, whereas older children are heavier than their food-secure counterparts, implying a double burden of undernutrition–overnutrition associated with child food insecurity. Child food and nutrition programmes to improve food insecurity should focus on infants and children in the transition ages.