bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300
Authors: Marvaso Giulia , Vischioni Barbara , Pepa Matteo , Zaffaroni Mattia , Volpe Stefania , Patti Filippo , Bellerba Federica , Gandini Sara , Comi Stefania , Corrao Giulia , Zerini Dario , Augugliaro Matteo , Fodor Cristiana , Russo Stefania , Molinelli Silvia , Ciocca Mario , Ricotti Rosalinda , Valvo Francesca , Giandini Tommaso , Avuzzi Barbara , Valdagni Riccardo , De Cobelli Ottavio , Cattani Federica , Orlandi Ester , Jereczek-Fossa Barbara Alicja , Orecchia Roberto 
Published: November 2021

PurposeThis study represents a descriptive analysis of preliminary results of a Phase II trial on a novel mixed beam radiotherapy (RT) approach, consisting of carbon ions RT (CIRT) followed by intensity-modulated photon RT, in combination with hormonal therapy, for high-risk prostate cancer (HR PCa) with a special focus on acute toxicity.MethodsPrimary endpoint was the evaluation of safety in terms of acute toxicity. Secondary endpoints were early and long-term tolerability of treatment, quality of life (QoL), and efficacy. Data on acute and late toxicities were collected according to RTOG/EORTC. QoL of enrolled patients was assessed by IPSS, EORTC QLQ-C30, EORTC QLQ-PR25, and sexual activity by IIEF-5.ResultsTwenty-six patients were enrolled in the study, but only 15 completed so far the RT course and were included. Immediately after CIRT, no patients experienced GI/GU toxicity. At 1 and 3 months from the whole course RT completion, no GI/GU toxicities greater than grade 2 were observed. QoL scores were overall satisfactory.ConclusionsThe feasibility of the proposed mixed treatment schedule was assessed, and an excellent acute toxicity profile was recorded. Such findings instil confidence in the continuation of this mixed approach, with evaluation of long-term tolerability and efficacy.
The Effects of the COVID-19 Pandemic on Health and Well-Being of Children and Youth in Nova Scotia: Youth and Parent Perspectives
Authors: Caldwell Hilary A. T. , Hancock Friesen Camille L. , Kirk Sara F. L. 
Published: November 2021

Objectives: The COVID-19 pandemic led to school closures, cancellations of major events, and loss of in-person social interactions for children and youth. These restrictions undoubtedly impacted the lives of children and youth. This study describes the well-being of children and youth in Nova Scotia during the COVID-19 pandemic and their thoughts and feelings about the return to school, from the perspectives of both youth and parents.Methods: A province-wide survey was conducted in August 2020 with parents of school-age children and youth and youth to measure youth well-being since the pandemic began.Results: Parents of children and youth in grades pre-primary to 12 (n = 699; 53% girls) and youth in grades 3–12 (n = 279; 69% girls) completed the online survey. Perceptions of parents about children's emotions during the pandemic were: bored, safe, lonely, happy, and anxious. Youth reported feeling bored, relaxed, depressed, safe, and worried. Sixty-three percent of youth and 72% of parents reported that they/their child felt they were missing important life events. Parents reported that being with parents, being physically active and being with friends made their child feel positive. Youth reported that being with friends, pets and watching TV made them feel good during this time. Seventy-six percent of parents and 62% of youth reported they/their child were getting more screen time than before the pandemic. With schools closed, participants most frequently shared that they missed friends and social interactions, in-person learning, and extra-curricular activities. Youth and parents expressed worries about COVID-19 outbreaks and related restrictions when schools re-opened to in-person learning.Conclusion: The well-being of children and youth in Nova Scotia was greatly impacted by the COVID-19 pandemic and related school closures in 2020. It is essential that pandemic recovery plans prioritize the health and well-being of children and youth.
Factors Influencing Residents' Psychological Status During Standardized Training in COVID-19
Authors: Xiang Dongfang , Liang Bao , Wang Yongyi , Li Biao , Peng Juan , Zhang Sheng , Chen Bei , Yan Chuandong , Xu Chao 
Published: November 2021

Objectives: To explore the influencing factors of residents' psychological status during standardized training in COVID-19 for finding ways to promote their mental health.Methods: A total of 760 residents were surveyed with a structured questionnaire. Correlation analysis was used to analyze the influencing factors of psychological status of the residents, and a mediation model was constructed to verify the mediating role of satisfaction.Results: Age, willingness to study medicine, and satisfaction were positively correlated with negative psychological status (P &lt; 0.05). And gender, only child or not, and annual household income (RMB) were negatively correlated with negative psychological status (P &lt; 0.01). Residents' satisfaction with standardized training mode plays a complete mediating role between annual household income and negative psychological status.Conclusions: Our findings emphasize the importance of concentrating on resident's psychological status and family economic situation. And relative departments should take action to optimize the standardized training mode to improve the satisfaction.
Reactive Transport Modelling of the Long-Term Interaction between Carbon Steel and MX-80 Bentonite at 25 °C
Authors: Chaparro M. Carme , Finck Nicolas , Metz Volker , Geckeis Horst 
Published: November 2021

The geological disposal in deep bedrock repositories is the preferred option for the management of high-level radioactive waste (HLW). In some of these concepts, carbon steel is considered as a potential canister material and bentonites are planned as backfill material to protect metallic waste containers. Therefore, a 1D radial reactive transport model has been developed in order to better understand the processes occurring during the long-term iron-bentonite interaction. The numerical model accounts for diffusion, aqueous complexation reactions, mineral dissolution/precipitation and cation exchange at a constant temperature of 25 °C under anoxic conditions. Our results suggest that Fe is sorbed at the montmorillonite surface via cation exchange in the short-term, and it is consumed by formation of the secondary phases in the long-term. The numerical model predicts precipitation of nontronite, magnetite and greenalite as corrosion products. Calcite precipitates due to cation exchange in the short-term and due to montmorillonite dissolution in the long-term. Results further reveal a significant increase in pH in the long-term, while dissolution/precipitation reactions result in limited variations of the porosity. A sensitivity analysis has also been performed to test the effect of selected parameters, such as corrosion rate, diffusion coefficient and composition of the bentonite porewater, on the corrosion processes. Overall, outcomes suggest that the predicted main corrosion products in the long-term are Fe-silicate minerals, such phases thus should deserve further attention as a chemical barrier in the diffusion of radionuclides to the repository far field.
Choosing the chemicals and advanced filter media for enhancing the process of mine water purification
Authors: Касперович В.Ю. 
Published: November 2021

В настоящее время строительство сооружений для очистки шахтных вод является одним из важных мероприятий, направленных на сохранение поверхностных водотоков и водоемов. Количество сбрасываемых шахтных вод в поверхностные водоемы может быть сокращено в результате их использования для комплексного обеспыливания в шахтах, технического водоснабжения и других наиболее водоемких технологических процессов. Одним из эффективных способов очистки шахтных вод от взвешенных веществ и тяжелых металлов является реагентная обработка высокомолекулярными флокулянтами, использование которых позволяет уменьшить расход неорганических коагулянтов и интенсифицировать процесс осаждения взвешенных веществ и тяжелых металлов. Предварительная обработка шахтной воды перед контактными осветлителями позволяет значительно увеличить пропускную способность действующих очистных сооружений, стабилизировать их работу при колебании качественного состава и температуры шахтной воды, снизить нагрузку на последующие стадии очистки на скорых фильтрах. Представлены результаты экспериментальных лабораторных исследований пробной коагуляции и флокуляции с последующим фильтрованием на скорых фильтрах с применением каталитической фильтрующей загрузки Orefilter В, сорбента АС и сорбционной загрузки Extrasorb, а также удаления (отдувки) аммиака из шахтной воды.
Currently, the construction of facilities for the purification of mine waters is one of the important measures aimed at preserving surface watercourses and water reservoirs. The amount of mine water discharged into surface water bodies can be reduced by reusing it for complex dedusting in mines, process water supply and other most water-intensive technological processes. One of the effective ways of removing suspended solids and heavy metals from mine water is chemical treatment with high-molecular flocculants that provide for reducing the consumption of inorganic coagulants and enhancing the process of suspended solids and heavy metals precipitation. Pretreatment of mine water upstream contact clarifiers can significantly increase the capacity of existing treatment facilities, stabilize their operation in case of fluctuations in the quality composition and temperature of mine water, and reduce the load on the subsequent stages of filtration in rapid filters. The results of experimental laboratory studies of trial coagulation and flocculation with subsequent filtration in rapid filters using Orefilter B catalytic filtering media, AS sorbent and Extrasorb sorption media, as well as removing (stripping) ammonia from mine water are presented.
Impact of Covid-19 Virus on Ophthalmology Residents and Fellows in a Tertiary Care Hospital
Authors: Nawaz Maryum 
Published: November 2021

Purpose: To determine the impact of COVID-19 pandemic on the training of Ophthalmology residents and fellows in a tertiary care hospital.
Study Design: Cross sectional survey.
Place and Duration of Study: The study was conducted in a tertiary care hospital, Peshawar from august 1st to august 20th 2020.
Methods: A self-designed questionnaire was distributed among 50 ophthalmology residents and fellows. Under-graduate students, house officers and post-graduate trainees from other specialties were excluded. Questions comprised of demographic data, and questions which were meant to investigate the changes experienced by the trainees during COVID-19. The data was analyzed by SPSS Software (Version 19).
Results: Among 50 participants of this study, 16 (32%) were females and 34 (68%) were males. The age ranged from 27 to 35 years. There was no statistically significant difference in the perspectives of resident trainees and fellows regarding negative impact of COVID-19 on their training. Ninety-five percent of the residents and fifty five percent of the fellows had effect on their clinical skills with p values of less than 0.05. Hundred percent residents agreed that online case presentation could not replace the traditional long rounds and simulator based training could improve the surgical skills in pandemic. Twenty five (60.97%) trainees and 6 (66.66%) fellows mentioned that pandemic affected them psychologically and they felt fear while working.
Conclusion: COVID-19 has adversely affected the training of post graduate trainees. Training directors should ensure to provide modern technological tools to improve trainees’ clinical and surgical skills until the crisis is over.
Key Words: COVID-19, Ophthalmology, Training, Conference.
Excellent Healing after Severe Lid Injury by a Bird
Authors: Chaudhry Tanveer , Shamim Nida 
Published: November 2021

Eye lid lacerations secondary to penetrating trauma is quite common. Most of the injuries occur due to animal bites, falls and collision with sharp objects. They may lead to partial or full thickness lid defects. We report a case of middle aged woman who was attacked by bird claws and sustained severe upper lid laceration that was immediately thoroughly investigated and then managed surgically resulting in excellent wound healing. Ocular trauma from bird pecking injury can cause blindness in humans. The public should guard against feeding and keeping close with them. If immediate medical attention is given by the ophthalmologist and urgent primary repair is done there are high chances to save the eye from disastrous complications.
Key Words: Lid laceration, ocular trauma, penetrating injury.
Effect of Online Classes on Dry Eye Disease in Children: A Hospital Based Survey
Authors: Salimath Sangameshwarayya , Sultana Salma , Patil Brijesh Appasaheb , Kulkarni Kalpana R , Nyamagoudar Shishir K. 
Published: November 2021

Purpose: To determine the effect of online classes on dry eye disease in children.
Study Design: Cross sectional study.
Place and Duration of Study: Department of Ophthalmology HSK hospital, Navanagar, Bagalkot, India, from October 2020 to November 2020.
Methods: A total of 454 students attending online classes between the ages of 3 – 18 years were selected. Questionnaire was presented which included name, age, sex, residence, duration of online studies and duration in hours per day along with the various signs and symptoms according to SPEED questionnaire. Statistical analysis was performed using the IBM SPSS version 17. Quantitative variables were presented as mean ± standard deviation, while qualitative data was presented as frequency and percentages and compared by chi square test. P-value of < 0.005 was considered as significant.
Results: Of the 454 responses, 316 (69.6%) had symptoms of dry eye disease, of which 159 were girls and 157 boys. There was no significant difference between boys and girls. Children taking online classes for 2 – 3 hours and for 4 to 6 months duration were more affected by the dry eye disease. Based on severity of grading system, 246 (84.2%) had mild symptoms, 42 (9.3%) had moderate symptoms and 28 ([6.2%) had severe symptoms. One hundred and twenty children visited ophthalmologist and 28.5% had their treatment of dry eye started.
Conclusion: Online classes have resulted in increase in the frequency of dry eye disease in children. Proper education about the usage of screen time and educating parents about early treatment is essential.
Key Words: Dry eye disease, Symptoms, Headache, Online learning.
MODELING OF SCHEMES OF CRACK DEVELOPMENT IN SHAPE SHELLS BASED ON TRAJECTORIES OF THE LARGEST TENSION STRESS
Authors: Аверин А. Н. , Аверина Т. А. 
Published: November 2021

В статье для пологой оболочки, загруженной равномерно распределенной нагрузкой, со схемой опирания на шарнирные опоры получено аналитическое решение. Нагрузка и неизвестные функции прогиба и напряжений представлены с помощью двойных тригонометрических рядов. Выполнены расчеты напряженно-деформированного состояния, определены усилия и перемещения. Дана оценка точности суммирования рядов по перемещениям и усилиям. В окрестности точек нижней, срединной и верхней поверхностей оболочки вычислены нормальные и касательные напряжения, а также главные напряжения и главные площадки. Показана картина двухосного напряженного состояния и на ее основе построены графики траекторий наибольших растягивающих напряжений. Графики траекторий на нижней поверхности оболочки сопоставлены с экспериментальными схемами развития трещин. По траекториям наибольших растягивающих напряжений, построенных в точках нижней поверхности, делается прогноз о месте, направлении и последовательности появления трещин в оболочке.
An analytical solution is obtained in the article for a shallow shell loaded with a uniformly distributed load, with a scheme of bearing on hinged supports. Load and unknown deflection and stress functions are represented using double trigonometric series. Calculations of the stress-strain state were performed, forces and displacements were determined. An assessment of the accuracy of summation of the series of displacements and efforts is given. In the vicinity of the points of the lower, middle and upper surfaces of the shell, normal and shear stresses, as well as principal stresses and principal areas, are calculated. The picture of the biaxial stress state is shown and on its basis, the graphs of the trajectories of the highest tensile stresses are constructed. The trajectory plots on the lower surface of the shell are compared with the experimental crack propagation schemes. The trajectories of the highest tensile stresses plotted at the points of the lower surface are used to predict the location, direction, and sequence of cracks in the shell.
Turkey’s Evolving Strategy in Libya: A Winning Gambit for Erdoğan?
Authors: Ramani Samuel 
Published: November 2021

Initiée en janvier 2020, l’intervention militaire de la Turquie en Libye dérouta la marche du général Khalifa Haftar sur Tripoli et modifia le cours de la guerre civile. Aujourd’hui, le Gouvernement d’Union Nationale libyen consolide ses positions. Cependant que le pays se prépare pour les élections de décembre 2021, Ankara aspire à consolider des contrats juteux sur le marché de la reconstruction, à préserver sa présence militaire formelle en Libye, et à s’affirmer comme un partenaire diplomatique indispensable.
Lieux du traumatique, le génocide : le nouage collectif-individuel
Authors: Weil Éva 
Published: November 2021

La clinique des rescapés et de leurs descendants est abordée à travers le paradigme du génocide. Les emblématiques théories du trauma se confrontent à la vérité historique, la vérité psychique, l’épreuve de réalité, et à « l’être analyste », héritier de la généalogie freudienne et de l’Histoire du xxe siècle. L’hypothèse de la latence dans le collectif, révélée par les effets processuels de sa rupture, se noue aux archives psychiques du collectif telles qu’elles se déploient dans la littérature, particulièrement chez Isaac Bashevis Singer. Refoulement, mise à l’écart, mise en suspens se combinent dans cette latence. Une figuration des endommagements individuels et collectifs du pare-excitation par les quantités massives de la Seconde Guerre mondiale, à partir d’Au-delà du principe de plaisir (Freud, 1920g), est proposée où la présence d’un autrui, après, s’avère fondamentale. L’individuelcollectif des sujets et du socius sous sa forme continue/discontinue se lierait dans un nouage associant l’être singulier, les effets des traumas collectifs, l’aléatoire et le hasard.
Entre corps et âme. La métapsychologie fragile et durable
Authors: Bonard Olivier 
Published: November 2021

Les rapports du congrès font appel à certaines notions métapsychologiques personnelles de leurs auteurs. Cette créativité témoigne de la vitalité de la métapsychologie lorsqu’elle est l’écho de la psyché du psychanalyste et de son patient, avec ses élans et ses renoncements. Freud en témoigne régulièrement. Mon commentaire s’arrête sur deux points : l’appel à la philosophie dans la métapsychologie et la régulation de la mise en latence par le collectif ; à ces deux points se rencontrent la théorie et sa nécessaire incarnation.
La psychanalyse est le lieu de la sur-vivance
Authors: Kristeva Julia 
Published: November 2021

Le lieu analytique est un lieu provisoire entre exode et exil avant le retour : on ne quitte pas Jérusalem quand on entre en psychanalyse. Mais surtout, le lieu psychanalytique est une temporalité de la relation transféro-contretransférentielle, celle de la sur-vivance. En définitive il est le lieu de l’écoute de la chair des mots. Cette écoute transforme les traumas en expérience intérieure, une appropriation de la vie jusque dans la mort. Le lieu du combat de l’espèce humaine pour la vie.
Atopie et utopie
Authors: Coblence Françoise 
Published: November 2021

L’interrogation sur le lieu psychique fait-elle éclater les topiques ? Dans la continuité des deux rapports, quels remaniements opérer ? Face aux traumatismes collectifs extrêmes, le jeu entre moi et surmoi est-il encore possible ? L’humour en constitue un premier exemple. Mais quelles traces sont gardées et transmises des expériences proprement inassimilables ? Dans quel lieu le sont-elles ? La réflexion sur les « villes refuges » (Levinas) et le Makom introduit pose la question de la place de l’infini.
Evaluation of Health-Related Quality of Life in Adult Patients on Hemodialysis
Authors: Sethi Suman , Menon Arshdeep , Dhooria Harmeet Pal Singh , Makkar Vikas , Dhooria Gurdeep Singh , Chaudhary Rupesh 
Published: November 2021

Background:
Hemodialysis in end-stage renal disease patients causes disability in different domains of patient's lives, leading to impaired (quality of life [QOL]). Studies measuring the QOL in patients on renal replacement therapy are limited in the Indian scenario.

Aims:
To evaluate the QOL in adult patients on maintenance hemodialysis by applying the World Health Organization QOL (WHOQOL)-BREF scale.

Material and Methods and Study Design:
Health-related QOL was evaluated in 100 adult patients on maintenance haemodialysis for 3 months or more in Dayanand Medical College and Hospital, Ludhiana. The WHOQOL-BREF was applied in these patients and the physical, psychological, social, and environmental health domains were assessed.

Results:
Most common age group was 31–60 years (56%) with a mean age of 54.44 years, male: 74%. Patients with age more than 60 years had better QOL scores in the social domain which was statistically significant (P = 0.005). Male patients had better scores in all four domains and was significant in the social domain (P = 0.025). Married patients had better QOL scores in social domain. Duration of dialysis had a reverse correlation with QOL scores in physical domain with better scores in dialysis duration of <12 months. Frequency of dialysis did not significantly affect the QOL scores. QOL scores were directly related to the monthly family income in all four domains with the highest income group showing better scores (P < 0.05).

Conclusion:
The present study provided an insight into the factors that affect the QOL in hemodialysis patients. Patients with age >60 years had better QOL scores in the social domain. Female gender, low serum proteins, HD duration of more than 1 year, and low monthly income were found to be associated with impaired QOL domains in patients undergoing maintenance hemodialysis.
Proteomic analysis of the influence of CO2 pneumoperitoneum in cervical cancer cells
Authors: Lv Hongtao , Zhou Ting , Rong Fengnian 
Published: November 2021

Objective:
The effect of CO2 pneumoperitoneum (CDP) on the oncology outcomes of patients undergoing laparoscopic radical hysterectomy for cervical cancer remains unclear. In this study, we investigated the effects of CDP on the proliferation of cervical cancer cells and examined the molecular mechanism.

Materials and Methods:
We established an in vitro CDP model to study the effects of CDP on the proliferation of cervical cancer cells by Cell Counting Kit-8 (CCK-8) assay, xenografted tumor assay. Tandem mass tag-based quantitative proteomics were used to study the proteomic changes in HeLa cells after CDP treatment. Western blot assay was used to detect the expressions of PI3K/Akt signaling pathway proteins.

Results:
CDP increased cell proliferation after a short period of inhibition in vitro and promoted tumorigenesis in vivo. Proteomic analysis showed that the expression levels of 177 and 309 proteins were changed significantly 24 and 48 h after CDP treatment, respectively. The acidification caused by CO2 inhibited the proliferation of cervical cancer cells by inhibiting the phosphorylation of PI3K and Akt.

Conclusions:
CDP promoted the proliferation of human cervical cancer cells after a short time of inhibition. The mechanism of which is related to the inhibition of phosphorylation of the PI3K/Akt signaling pathway.