bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen peroxide enhanced sonophotocatalytic degradation of acid orange 7 in aqueous solution: optimization by Box–Behnken design
Authors: Wei Haoxuan , Rahaman Md. Hasibur , Zhao Jujiao , Li Dayan , Zhai Jun 
Published: May 2021

AbstractBACKGROUNDSonophotocatalysis has gained great attention for research into practical applications to treat refractory organic dye from wastewater. However, its degradation efficiency needs to be improved further. To further enhance the sonophotocatalytic performance, here we report a novel hydrogen peroxide (H2O2)‐assisted titania (TiO2)‐based sonophotocatalyic system (H2O2‐US‐UV/TiO2) for degradation of acid orange 7 (AO7).RESULTSEffects of operating parameters including catalyst dosage, concentration of the oxidative agents and initial pH were analyzed through a response surface method coupled with Box–Behnken experimental design (RSM‐BBD) and experiments. Introducing H2O2 into the US‐UV/TiO2 system can significantly enhance AO7 removal. A quadratic model was proposed for predicting AO7 degradation using the RSM‐BBD method, and the statistical significance of the model was confirmed by ANOVA. The real AO7 removal efficiency (95.8%) under experimental conditions of 0.5 g L−1 TiO2, 4 mmol L–1 H2O2, and initial pH 3 was comparable with the predicated value (98.6%) obtained from this model. Quenching tests revealed that the hydroxyl radical (˙OH) was the key reactive species in the sonophotocatalytic system. Degradation products including 2‐naphthol, 4‐carboxylphenylglycine, cinnamic acid and 1,10‐Decanediol were identified.CONCLUSIONAdding H2O2 improved the degradation performance of AO7 in the US‐UV/TiO2 system; H2O2 concentration was a more significant experimental factor than initial pH and TiO2 dosage. A degradation pathway of AO7 removal was suggested according to results of liquid chromatography‐mass spectrometry. The novel hybrid H2O2‐US‐UV/TiO2 system can be utilized as an efficient process for recalcitrant dye wastewater treatment. © 2021 Society of Chemical Industry (SCI).
Team Regulatory Focus and its Role for Idea Generation, Idea Implementation, and Innovative Performance: A Dynamic Perspective
Authors: Hundeling Maike , Auerswald Max , Rosing Kathrin 
Published: May 2021

AbstractIn an experimental study, we explored the relationships between team regulatory focus and temporal patterns of innovative activities as well as innovative performance. We manipulated regulatory focus in 44 student teams and assessed idea generation and implementation activities over time based on video data. External raters assessed innovative performance. Latent growth curve models revealed that higher team promotion focus increased idea generation at the beginning of an innovative project but decreased this activity over time. High levels of idea generation at the beginning of a project were related to lower levels of originality, whereas a decline in idea generation over time was related to higher levels of originality. Unexpectedly, relationships between team prevention focus, idea implementation, and quality were not significant. Our findings contribute to a comprehensive perspective on team regulatory focus and innovation, emphasizing the importance of differentiating between activities and performance.
Meta‐analytic structural equation modeling made easy: A tutorial and web application for one‐stageMASEM
Authors: Jak Suzanne , Li Hongli , Kolbe Laura , de Jonge Hannelies , Cheung Mike W.‐L. 
Published: May 2021

AbstractMeta‐analytic structural equation modeling (MASEM) refers to fitting structural equation models (SEMs) (such as path models or factor models) to meta‐analytic data. Currently, fitting MASEMs may be challenging for researchers that are not accustomed to working with R software and packages. Therefore, we developed webMASEM; a web application for MASEM. This app implements the one‐stage MASEM approach, and allows users to apply MASEM in a user‐friendly way. The aim of this article is to provide a tutorial on one‐stage MASEM and a practical guide to webMASEM. We will pay specific attention to how the data should be structured and prepared for webMASEM, because mistakes in this step may lead to faulty results without receiving an error message. The use of webMASEM is illustrated with an analysis of a meta‐analytic path model in which the path coefficients are moderated by a study‐level variable, a meta‐analytic factor model in which the factor loadings are moderated by a study‐level variable, and a meta‐analytic panel model in which the effects are moderated by a study‐level variable. All used datafiles and R scripts are available online.
Quantitative analysis of γ‐glutamylisoleucine, γ‐glutamylthreonine, and γ‐glutamylvaline in HeLa cells using UHPLC‐MS/MS
Authors: Thacker Jonathan B. , He Chenchen , Pennathur Subramaniam 
Published: May 2021

Abstractγ‐Glutamylpeptides have been identified as potential biomarkers for a number of diseases including cancer, diabetes, and liver disease. In this study, we developed and validated a novel quantitative analytical strategy for measuring γ‐glutamylisoleucine, γ‐glutamylthreonine, and γ‐glutamylvaline, all of which have been previously reported as potential biomarkers for prostate cancer in HeLa cells using ultra‐high‐performance liquid chromatography‐tandem mass spectrometry. A BEH C18 column was used as the stationary phase. Mobile phase A was 99:1 water:formic acid and mobile phase B was acetonitrile. Chemical isotope labeling using benzoyl chloride was used as the internal standardization strategy. Sample preparation consisted of the addition of water to a frozen cell pellet, sonication, derivatization, centrifugation, and subsequent addition of an internal standard solution. The method was validated for selectivity, accuracy, precision, linearity, and stability. The determined concentrations of γ‐glutamylisoleucine, γ‐glutamylthreonine, and γ‐glutamylvaline in HeLa cells were 1.92 ± 0.06, 10.8 ± 0.4, and 1.96 ± 0.04 pmol/mg protein, respectively. In addition, the qualitative analysis of these analytes in human serum was achieved using a modified sample preparation strategy. To the best of our knowledge, this is the first report of the use of benzoyl chloride for chemical isotope labeling for metabolite quantitation in cells.
Eriodictyol attenuates TNBS‐induced ulcerative colitis through repressing TLR4/NF‐kB signaling pathway in rats
Authors: Hu Li‐Hong , Liu Jing‐Yang , Yin Ji‐Bin 
Published: May 2021

AbstractUlcerative colitis (UC) is a chronic disease characterized by mucosal and submucosal inflammation, which has a low cure rate and is prone to relapse, due to the immune imbalance of the body. Inhibition of inflammation‐related pathways can delay the progression of UC. Toll‐like receptor 4 (TLR4) pathway is considered to be one of the important signaling pathways involved in colon inflammation. Eriodictyol (EDT) is a natural flavonoid widely distributed in foodborne plants. EDT plays an important role in the regulation of inflammation and related signaling pathways. However, whether EDT plays a role in UC remains unknown. Herein, we established a TNBS induced animal model of enteritis in Wistar rats. Our data confirmed the establishment of TNBS induced animal model of enteritis and the administration Eriodictyol in Wistar rats. EDT treatment alleviated TNBS‐induced intestinal tissue injury in rats. We further found that EDT reduced MPO expression and regulated the cytokine parameters in TNBS‐induced intestinal tissues of rats. The levels of TNF‐α, IL‐1β, IL‐6, IL‐10, IL‐2, and IL‐12 were also affected by the treatment of EDT. EDT also affected SOD, CAT, GSH‐Px, and MDA level in rats with colitis. Moreover, EDT regulated TNBS‐induced TLR4/NF‐κB pathway activation, therefore inhibiting the progression of UC. Our results suggest that EDT could be a potential therapeutic agent for UC.
A clinical‐radiomics model incorporating T2‐weighted and diffusion‐weighted magnetic resonance images predicts the existence of lymphovascular invasion / perineural invasion in patients with colorectal cancer
Authors: Zhang Ke , Ren Yiyue , Xu Shufeng , Lu Wei , Xie Shengnan , Qu Jiali , Wang Xiaoyan , Shen Bo , Pang Peipei , Cai Xiujun , Sun Jihong 
Published: May 2021

PurposeLymphovascular invasion (LVI) and perineural invasion (PNI) are independent prognostic factors in patients with colorectal cancer (CRC). In this study, we aimed to develop and validate a preoperative predictive model based on high‐throughput radiomic features and clinical factors for accurate prediction of LVI/PNI in these patients.MethodsTwo hundred and sixty‐three patients who underwent colorectal resection for histologically confirmed CRC between 1 February 2011 and 30 June 2020 were retrospectively enrolled. Between 1 February 2011 and 30 September 2018, 213 patients were randomly divided into a training cohort (n = 149) and a validation cohort (n = 64) by a ratio of 7:3. We used a 10000‐iteration bootstrap analysis to estimate the prediction error and confidence interval for two cohorts. The independent test cohort consisted of 50 patients between 1 October 2018 and 30 June 2020. Regions of interest (ROIs) were manually delineated in high‐resolution T2‐weighted and diffusion‐weighted images using ITK‐SNAP software on each CRC tumor slice. In total, 3356 radiomic features were extracted from each ROI. Next, we used the maximum relevance minimum redundancy and least absolute shrinkage and selection operator algorithms to select the strongest of these features to establish a clinical‐radiomics model for predicting LVI/PNI. Receiver‐operating characteristic and calibration curves were then plotted to evaluate the predictive performance of the model in the training, validation, and independent test cohorts.ResultsA multiparametric clinical‐radiomics model combining MRI‐reported extramural vascular invasion (EMVI) status and a Radiomics score for the LVI/PNI estimation was established. This model had significant predictive power in the training cohort (area under the curve [AUC] 0.91; 95% confidence interval [CI]: 0.85–0.97), validation cohort (AUC: 0.88; 95% CI: 0.79–89), and independent test cohorts (AUC 0.83, 95% CI 0.72–0.95). The model performed well in the independent test cohort with sensitivity of 0.818, specificity of 0.714, and accuracy of 0.760. Calibration curve and decision curve analysis demonstrated clinical benefits.ConclusionMultiparametric clinical‐radiomics models can accurately predict LVI/PNI in patients with CRC. Our model has predictive ability that should improve preoperative diagnostic performance and allow more individualized treatment decisions.
Urbanization and respiratory stress in the Northern Low Countries: A comparative study of chronic maxillary sinusitis in two early modern sites from the Netherlands (AD 1626–1866)
Authors: Casna Maia , Burrell Carla L. , Schats Rachel , Hoogland Menno L. P. , Schrader Sarah A. 
Published: May 2021

AbstractThe aim of this study was to investigate the relationship between urbanization and upper respiratory health in two early modern populations from the Netherlands. For this purpose, we analyzed the prevalence of chronic maxillary sinusitis in the adult urban population of Arnhem (n = 83) and in the rural village of Middenbeemster (n = 74). A slightly higher prevalence of chronic maxillary sinusitis was observed in the Arnhem sample (55.4%) compared with the Middenbeemster sample (51.3%), and these variations were not statistically significantly different. Although historical sources attest to the fact that life in the postmedieval settlements of Arnhem and Middenbeemster greatly differed, our results suggest that both environments exposed people to certain respiratory hazards. Furthermore, sinusitis prevalence was also investigated in correlation to sex, as urbanization in the Netherlands often involved women in factory work in direct contrast to the traditional domestic role they kept covering in rural environments. No significant differences were observed between males and females, both in an intersite (Arnhem males vs. Middenbeemster males; Arnhem females vs. Middenbeemster females) and in an intrasite (males vs. females at Arnhem; males vs. females at Middenbemster) comparison. As men and women in Arnhem worked on similar tasks, our results confirm that they were both exposed to similar risk factors. In Middenbeemster, where women mainly stayed inside taking care of the house while men worked the fields, the adverse weather conditions and continuous exposure to pollens and allergens may have enhanced men's chances of contracting chronic maxillary sinusitis. This study suggests that urbanization in the early modern Netherlands was in fact not inherently more detrimental than rural living. Future research incorporating a larger sample from other Dutch sites is being considered to better frame the complex etiology of sinusitis within the present understanding of historic regional variation in urbanization patterns.
Views from Multidisciplinary Oncology Clinicians on Strengthening Cancer Care Delivery Systems in Tanzania
Authors: Nyagabona Sarah Kutika , Luhar Rohan , Ndumbalo Jerry , Mvungi Nanzoke , Ngoma Mamsau , Meena Stephen , Siu Sadiq , Said Mwamvita , Mwaiselage Julius , Tarimo Edith , Buckle Geoffrey , Selekwa Msiba , Mushi Beatrice , Mmbaga Elia John , Van Loon Katherine , DeBoer Rebecca J. 
Published: May 2021

Abstract

Background
In response to the increasing burden of cancer in Tanzania, the Ministry of Health, Community Development, Gender, Elderly and Children launched National Cancer Treatment Guidelines (TNCTG) in February 2020. The guidelines aimed to improve and standardize oncology care in the country. At Ocean Road Cancer Institute (ORCI), we developed a theory-informed implementation strategy to promote guideline-concordant care. As part of the situation analysis for implementation strategy development, we conducted focus group discussions to evaluate clinical systems and contextual factors that influence guideline-based practice prior to the launch of the TNCTG.

Materials and Methods
In June 2019, three focus group discussions were conducted with a total of 21 oncology clinicians at ORCI, stratified by profession. A discussion guide was used to stimulate dialogue about facilitators and barriers to delivery of guideline-concordant care. Discussions were audio recorded, transcribed, translated, and analyzed using thematic framework analysis.

Results
Participants identified factors both within the inner context of ORCI clinical systems and outside of ORCI. Themes within the clinical systems included capacity and infrastructure, information technology, communication, efficiency, and quality of services provided. Contextual factors external to ORCI included interinstitutional coordination, oncology capacity in peripheral hospitals, public awareness and beliefs, and financial barriers. Participants provided pragmatic suggestions for strengthening cancer care delivery in Tanzania.

Conclusion
Our results highlight several barriers and facilitators within and outside of the clinical systems at ORCI that may affect uptake of the TNCTG. Our findings were used to inform a broader guideline implementation strategy, in an effort to improve uptake of the TNCTGs at ORCI.

Implications for Practice
This study provides an assessment of cancer care delivery systems in a low resource setting from the unique perspectives of local multidisciplinary oncology clinicians. Situational analysis of contextual factors that are likely to influence guideline implementation outcomes is the first step of developing an implementation strategy for cancer treatment guidelines. Many of the barriers identified in this study represent actionable targets that will inform the next phases of our implementation strategy for guideline-concordant cancer care in Tanzania and comparable settings.
Sustainable and high‐performance ternary blends from polylactide, CO2‐based polyester and microbial polyesters with different chemical structure
Authors: Zuo Huijie , Liu Juyang , Huang Dong , Bai Yuanbin , Cui Liang , Pan Li , Zhang Kunyu , Wang Huaiyuan 
Published: May 2021

AbstractHerein, high‐performance sustainable ternary blends were prepared via a melt blending method from completely biodegradable polyesters, namely commercial polylactide (PLA), poly(propylene carbonate) (PPC) and a series of poly(hydroxyalkanoate)s (PHAs), including poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV), poly(3‐hydoxybutyrate‐co‐3‐hydroxyhexanoate) (PHBHHx) and two types of poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) (P34HB) having different 3HB molar ratios. The miscibility, phase structure, mechanical and thermal properties of the blends were investigated to deeply understand the influence of the blend compositions and species of PHAs on the structure and physical performance of the multiphase blends. Thermal and morphological analysis revealed that the PLA, PPC and PHAs components showed partial miscibility with each other, especially the blend with P34HB of a low 3HB ratio. Remarkable enhancement in the ductility and toughness of PLA was gained by the addition of PPC and P34HB. An optimum tensile strain of 171% was achieved for the PLA/PPC/P34HB (60/30/10) blend, while PLA/PPC/P34HB (60/10/30) blend showed the highest impact strength with a value of 45 kJ m−2, which is 14 times higher than that of PLA. Synergistic toughening from the flexible PPC and P34HB phase with a degree of interfacial compatibilization played an effective role in enhancing the mechanical performance of the ternary blends.
Determinants of social functioning among adolescents and young adults with cancer: A systematic review
Authors: Schilstra Clarissa E. , Fardell Joanna E. , Burns Mary A. , Ellis Sarah J. , Anazodo Antoinette C. , Trahair Toby N. , Sansom‐Daly Ursula M. 
Published: May 2021

AbstractObjectivesSurvivors of adolescent and young adult (AYA) cancer report deficits in social functioning relative to healthy peers. Identifying factors related to their social functioning is critical to improve their long‐term social outcomes. This review addressed: (1) How is social functioning defined and measured among studies of AYAs who have had cancer? (2) What factors have quantitatively/qualitatively are associated with/predictors of social functioning? and (3) What associated factors/predictors of social functioning are modifiable and amenable to intervention?MethodsA systematic review was conducted to identify publications from 2000 to 2021, meeting these criteria: (1) mean/median age at diagnosis/treatment 13–40, (2) assessed social functioning with a validated measure and included factors associated with/predictive of social functioning and/or qualitatively assessed young people's perceptions of factors related to their social functioning and (3) was peer‐reviewed/published in English.ResultsThirty‐seven publications were included. Definitions and measures of social functioning varied, and factors related to social functioning varied based on definition. Factors most commonly associated with decreased social functioning included treatment status (receiving or completed treatment), poor physical functioning, depression, negative body image, engaging in social comparisons, social/cultural stigma around cancer, and fatigue. Increased social functioning was most commonly associated with social support and the quality/age‐appropriateness of care.ConclusionsSocial functioning is multidimensional construct for AYAs diagnosed with cancer and may not be adequately assessed with measures of adjustment or quality of life. Future studies should clarify how to optimally define and measure social functioning in this population, to ensure their functioning can be protected and promoted long‐term.
Prematurity, the diagnosis of bronchopulmonary dysplasia, and maturation of ventilatory control
Authors: Mammel Daniel , Kemp James 
Published: May 2021

AbstractInfants born before 32 weeks gestational age and receiving respiratory support at 36 weeks postmenstrual age (PMA) are diagnosed with bronchopulmonary dysplasia (BPD). This label suggests that their need for supplemental oxygen (O2) is primarily due to acquired dysplasia of airways and airspaces, and that the supplemental O2 is treating residual parenchymal lung disease. However, emerging evidence suggests that immature ventilatory control may also contribute to the need for supplemental O2 at 36 weeks PMA. In all newborns, maturation of ventilatory control continues ex utero and is a plastic process. Among premature infants, supplemental O2 mitigates the hypoxemic effects of delayed maturation of ventilatory control, as well as reduces the duration and frequency of periodic breathing events. Nevertheless, prematurity is associated with altered and occasionally aberrant maturation of ventilatory control. Infants born prematurely, with or without a diagnosis of BPD, are more prone to long‐lasting effects of dysfunctional ventilatory control. This review addresses normal and abnormal maturation of ventilatory control and suggests how aberrant maturation complicates assigning the diagnosis of BPD. Greater awareness of the interaction between parenchymal lung disease and delayed maturation of ventilatory control is essential to understanding why a given premature infant requires and is benefitting from supplemental O2 at 36 weeks PMA.
More on Sombor indices of chemical graphs and their applications to the boiling point of benzenoid hydrocarbons
Authors: Liu Hechao , Chen Hanlin , Xiao Qiqi , Fang Xiaona , Tang Zikai 
Published: May 2021

AbstractLet G be a connected graph with vertex set V(G) and edge set E(G). The Sombor index of G is defined as and the reduced Sombor index of G is defined as where du denotes the degree of vertex u in G. In this paper, we determine maximum and minimum (reduced) Sombor index of chemical trees with given pendent vertices, and characterize their extremal graphs. In addition, some numerical results are discussed. We calculate the (reduced) Sombor index of a set of benzenoid hydrocarbons. The regression models show that boiling points and (reduced) Sombor index of benzenoid hydrocarbons are highly correlated.