bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humoral and cellular responses after a third dose of BNT162b2 vaccine in patients with lymphoid malignancies
Authors: Re Daniel , Seitz-Polski Barbara , Carles Michel , Brglez Vesna , Graça Daisy , Benzaken Sylvia , Liguori Stéphane , Zahreddine Khaled , Delforge Margaux , Verrière Benjamin , Chamorey Emmanuel , Barrière Jérôme 
Published: July 2021

Abstract
BACKGROUND: Immunocompromised patients such as patients with hematological malignancies have impaired immune response to two doses of BNT162b2 (Pfizer / BioNtech) vaccine against SARS-CoV-2. Evaluation of a repeated immune stimulation with a third vaccine dose is needed.METHODS: a vaccine monitoring observatory was conducted in outpatients who were treated for lymphoid malignancies (LM) to monitor both immune and cellular response measured the day of administration of the dose 3 of the mRNA vaccine BNT162b2 and again three to four weeks. Elecsys ® Anti-SARS-CoV-2 immunoassay was used to asses to the level of SARS-CoV-2 anti-Spike (S) antibodies (Abs) titer and SARS-CoV-2-specific T-cell responses were assessed by a whole blood Interferon-Gamma Release Immuno Assay (IGRA) (QuantiFERON Human IFN-gamma SARS-CoV-2, Qiagen®).RESULTS: Among the 43 assessable patients (suffering from chronic lymphocytic leukemia (CLL) (n=15), indolent and aggressive B cell non-Hodgkin lymphoma (NHL) (n=14), and multiple myeloma (MM) (n=16)), 18 (41,8%) had no anti-S Abs before the dose 3 of BNT162b2 vaccine (n=9 CLL, n=8 NHL, n=1 MM), and they all 18 remained negative after the dose 3. Amongst the 25 patients with positive anti-S titers before dose 3, all patients remained positive and 23 patients increased their anti-S titer after dose 3. Patients with CLL and/or with previous anti-CD20 therapy treated within 12 months of administration of dose 3 had no significant increase of the humoral response. Among 22 available patients, dose 3 of BNT162b2 vaccine significantly increased the median IFN-gamma secretion. On eight (36.4%) patients who were double-negative for both immune and cellular response, five (22.7%) patients remained double-negative after dose 3.CONCLUSIONSDose 3 of BNT162b2 vaccine stimulated humoral immune response among patients with LM, in particular patients with MM (who had higher anti-S baseline titer after dose 2) and those with no anti-CD20 treatment history within a year. T-cell response was increased among patients in particular with no active chemotherapy regimen. Our data support the use of an early third vaccine dose among immunocompromised patients followed for LM though some of them will still have vaccine failure.
Association Between Ambient Air Pollutants and Meteorological Factors With SARS-CoV-2 Transmission and Mortality in India: an Exploratory Study
Authors: Aggarwal Sumit , Balaji Sivaraman , Singh Tanvi , Menon Geetha R , Mandal Sandeep , J Madhumathi , Mahajan Nupur , Kohli Simran , Kaur Jasmine , Singh Harpreet , Rade Kiran , Panda Samiran 
Published: July 2021

Abstract
Background: The Coronavirus disease 2019 (COVID-19) pandemic poses a serious public health concern worldwide. Certain regions of the globe were severely affected in terms of prevalence and mortality than other. Although the cause for this pattern is not clearly understood, lessons learned from previous epidemics and emerging evidences suggest the major role of ecological factors like ambient air pollutants (AAP) and meteorological parameters in increased COVID-19 incidence. The present study aimed to understand the impact of these factors on SARS-CoV-2 transmission and their associated mortality in major cities of India.Methods: This study used secondary AAP, meteorological and COVID-19 data from official websites for the period January-November 2020, which were divided into Pre-lockdown (January-March 2020), Phase I (April to June 2020) and Phase II (July to November 2020). After comprehensive screening, five major cities that includes 48 CPCB monitoring stations collecting daily data of ambient temperature, particulate matter PM2.5 and 10 were analysed. Spearman and Kendall’s rank correlation test was performed to understand the association between SARS-CoV-2 transmission and AAP and, meteorological variables. Similarly, case fatality rate (CFR) was determined to compute the correlation between AAP and COVID-19 related morality.Results: The level of air pollutants in major cities were significantly reduced during Phase I compared to Pre-lock down and increased upon Phase II in all the cities. During the Phase II in Delhi, the strong significant positive correlation was observed between the AAP and SARS-CoV-2 transmission. However, in Bengaluru, Hyderabad, Kolkata and Mumbai AAP levels were moderate and no correlation was noticed. The relation between AT and SARS-CoV-2 transmission was inconclusive as both positive and negative correlation observed. In addition, Delhi and Kolkata showed a positive association between long-term exposure to the AAP and COVID-19 CFR. Conclusion: Our findings support the hypothesis that the particulate matter upon exceeding the satisfactory level serves as an important cofactor in increasing the risk of SARS-CoV-2 transmission and related mortality. These findings would help public health experts to understand the SARS-CoV-2 transmission against ecological variables in India and provides supporting evidence to healthcare policymakers and government agencies for formulating strategies to combat the COVID-19.
Optimization of Tungsten Disulfide/Polypyrrole Composite as Photocatalyst in Sunlight-Asissted Photodegradation of Methylene Blue in Aqueous Solution
Authors: Baharin Siti Nor Atika , Hashim Nurul Hafawati , Norsham Izyan Najwa Mohd , Shahabuddin Syed , Sambasevam Kavirajaa Pandian 
Published: July 2021

Abstract
The present study highlights the sunlight-assisted photodegradation of methylene blue (MB) using tungsten disulphide/polypyrrole (WS2/PPy) composite as a photocatalyst. WS2/PPy was prepared via oxidative polymerization using ferric chloride (FeCl3) as an oxidant. Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and Field Emission Scanning Electron Microscope (FESEM) measurement were used to ensure the physicochemical properties of WS2/PPy. The photocatalytic efficiencies of the photocatalysts were examined by degrading methylene blue (MB) under sunlight irradiation. The results showed that the degradation efficiency of WS2/PPy was higher than the pristine PPy Several optimizations such as effect of the concentration, contact time, photocatalyst dosage and initial concentration were investigated. The results revealed that, under optimum condition of pH 3, 100 mg photocatalyst dosage, 10 ppm MB initial concentration within 180 minutes contact time, were the most effective parameters, that produced 96.15% of sunlight-assisted photodegradation in aqueous solution of MB.
One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers
Authors: Baghbanbashi Mojhdeh , Pazuki Gholamreza , Khoee Sepideh 
Published: July 2021

Abstract
Providing an efficient system for drug delivery and chemotherapy has always been an important issue. Modification of the surface of silica nanoparticles (SiO2) provides an opportunity for achieving stimulus-sensitive drug delivery system. Here, we have modified the surface of SiO2 using hydrogen bonding interactions by employing an aqueous two-phase system (ATPS) based on polyethylene glycol and lysine. This novel biocompatible ATPS provides an environment for simultaneous drug encapsulation, SiO2 modification, and drug partitioning in one pot. Addition of SiO2 to ATPS increased the partitioning of doxorubicin (DOX) as an anti-cancer drug from 47.92 in the absence of nanoparticles to 92.33 due to the interactions between drug and nanoparticles. The formation of nanoformulation and its characteristics were investigated applying microscopy, spectroscopy and thermal analysis. Drug release study demonstrated that DOX is loaded on nanoformulations efficiently with an encapsulation efficiency of 63.84% and shows lower release in physiological environment compared to the unmodified nanoparticles. While in acidic conditions of pH 5.5, significant increase was observed in the release profile. MTT assay on MCF-7 cancer cells confirmed that the nanoformulations were non-toxic and DOX-loaded nanocarrier showed anti-cancer behavior. These results indicate that the prepared nanoformulations are promising nanocarriers for controlled drug release purposes.
In Vitro Nitrogen Transformations by Pollen From Temperate Tree Species
Authors: Verstraeten Arne , Gottardini Elena , Bruffaerts Nicolas , Neirynck Johan , Genouw Gerrit 
Published: July 2021

Abstract
The effects of pollen on dissolved inorganic nitrogen (DIN) compounds in throughfall water are not completely understood. We conducted a 7-day leaching experiment with pollen from silver birch (including a sterilized control), European beech, sessile oak, Scots pine, Corsican black pine and Norway spruce using an immersion medium containing nitrate (11.295 mg N l-1). Within 2 hours, pollen released substantial amounts of potassium (K+), phosphate (PO3-) and organic compounds. Solute concentrations of ammonium (NH4+) were built up over time. In treatments with pollen from birch, oak and beech, nitrate (NO3-) concentrations started to decrease after 24–48 hours, while simultaneously nitrite (NO2-) emerged, but part of the inorganic nitrogen could no longer be detected in solution. For birch, sterilisation of the pollen made no difference, indicating that microorganisms on the pollen played no substantial role in the observed N transformations. Conditions in the samples were oxic (1.82–6.12 mg O2 l-1), rendering microbial denitrification unlikely. Our findings revealed that pollen from broadleaved deciduous trees can transform throughfall NO3- into NO2- and likely also nitric oxide (NO), probably through the nitrate reductase pathway. The synthesis of NH4+ might be part of a natural defence mechanism protecting reproductive organs against pathogens during pollination.
Preventive practices towards Sexually Transmitted Infection and its determinants among young people in Ethiopia: a protocol for a systematic review and Meta-analysis
Authors: Anbesu Etsay Woldu , Aychiluhm Setognal Birara , Alemayehu Mussie 
Published: July 2021

Abstract
Background: Globally, about 178.5 million new cases of curable sexually transmitted infections occur among young people aged 15-24 years. There are fragmented and inconsistent findings on preventive practices of sexually transmitted infection. Thus, this systematic review and meta-analysis aimed to estimate the pooled prevalence of preventive practices of sexually transmitted infection and identify its determinants among young people in Ethiopia. Methods: We will use the Preferred Reporting Items for Systematic review and Meta-analyses (PRISMA) to develop the review protocol. We will use online databases such as PubMed, CINAH, Google, and Google Scholar to search published and unpublished studies. We will use the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument to assess the quality. We will check statistical heterogeneity using the Cochran Q test and I2 statistics. We will perform subgroup analyses and meta-regression to identify the sources of heterogeneity. The statistical analysis will be done using STATA version-14 software. We will use a random-effects model to estimate the pooled prevalence and identify determinants of preventive practices of sexually transmitted infections. Discussion: Young people have a high unmet need for sexual and reproductive health services and poor preventive practices toward sexually transmitted infection. Although there are studies on the sexually transmitted infection preventive practice, there is no study finding on the pooled prevalence of the preventive practices of sexually transmitted infection and its determinants among young people in Ethiopia. Thus, this systematic review and meta-analysis will help to develop appropriate interventions.
Novel Double Slit Experiments: Right-hand Rule and Left-hand Rule ---Interference Patterns Curved, Expanded and Inclined Simultaneously
Authors: Peng Hui 
Published: July 2021

Abstract

Young’s double slit experiments express the mystery of quantum mechanics. To explore the mystery, varieties of the double slit experiments were performed. In this article, we show the novel double slit experiments in which the following three phenomena emerged simultaneously: see abstract figure in the downloadable PDF.(1) the interference patterns incline towards the axis that perpendicular to the axis the diaphragm rotating around; (2) the interference patterns curved; (3) the distances between the fringes of the interference patterns expanded. To determine the direction the pattern curved towards, we propose the right-hand rule for the clockwise rotating diaphragm and the left-hand rule for the counterclockwise rotating diaphragms. Those experiments show more mysteries of the double slit and provide comprehensive data for developing/testing a theoretical model.
Vaterite in a decrepitated diamond-bearing inclusion in zircon from a stromatic migmatite in the Chinese Sulu ultrahigh-pressure metamorphic belt
Authors: Fei Chenhui , Liu Jingbo 
Published: July 2021

Abstract
Vaterite was identified in a decrepitated carbonaceous material (CM) bearing inclusion in zircon from a stromatic migmatite in the Chinese Sulu ultrahigh-pressure (UHP) metamorphic terrane. It is associated with nanometer to micrometer anhedral diamonds, aragonite, calcite, amorphous C-Si-O, and amorphous Zr-Si-O materials. The inclusion developed offshoots and abundant indigenous holes. The C-Si-O material is carbon-rich and porous and shows diagnostic Raman bands of highly disordered CM, whereas the Zr-Si-O material is spherulitic or banded with little or no carbon. The observations from focused ion beam–scanning electron microscope (FIB-SEM) and transmission electron microscope (TEM) verify that both diamond and highly disordered CM are of indigenous origin. The formation pathway of vaterite means that an amorphous calcium carbonate (ACC) phase occurred as the precursor of vaterite. The highly disordered CM contains the subsidiary bands at 1150 and 1250 cm−1 on the low-frequency side of the D1 band, suggesting that there exist aliphatic hydrocarbon chains. Thus, the highly disordered CM was derived from carbonization of some kind of organic species in the fluid inclusion. Decrepitation of inclusion resulted in an extremely high supersaturation state of the fluid that induced the precipitation of amorphous materials and released residual fluid out of the inclusion, which became dry and preserved vaterite and amorphous materials.
Crystal structure determination of orthorhombic variscite2Oand its derivative AlPO4 structure at high temperature
Authors: Ardit Matteo , Phillips Brian L. , Bish David L. 
Published: July 2021

AbstractVariscite [Al(PO4)·2H2O] is an uncommon secondary phosphate mineral but is important in a variety of environmental and technological applications. It exists in at least one monoclinic (metavariscite) and two orthorhombic polymorphs (“Lucin-type” and “Messbach-type”), but the fine-grained nature of the “Messbach-type” variscite has hampered the determination of its crystal structure. The crystal structure of the latter from Tooele County, Utah, was solved and refined using laboratory powder X-ray diffraction (XRD) data, charge-flipping, and the Rietveld method. Both variscite modifications belong to the family of framework 3D MT structures in which octahedra (M) and tetrahedra (T) are linked by bridging O atoms. Topological analysis reveals that the two structures are polytypes. Based on our results and our structural interpretations, we refer to “Lucin-type” variscite as variscite1O and the “Messbach-type” as variscite2O, to be consistent with modern polytype terminology. The similarity of these two structures suggests that 1O-2O interstratifications may exist in nature, which is consistent with observed broadening of diffraction peaks of the Tooele material. 31P and 27Al MAS/NMR measurements are consistent with the XRD-determined crystal structure, and they show distinct signals for each of the two independent P and Al positions in variscite2O.High-temperature XRD, thermal analyses, and NMR measurements were applied to study the nature of the transformation of variscite2O to a derivative AlPO4 structure above 473 K. Charge-flipping analysis showed that the crystal structure of the new anhydrous AlPO4 phase (AlPO4-var2O in analogy to its parent structure) can be described as a 3D framework of alternating AlO4 and PO4 tetrahedra linked by bridging O atoms. Thermogravimetric analyses revealed almost complete dehydration above ~450 K, and NMR results were consistent with tetrahedral Al and P atoms.
A novel framework for prediction of dam deformation based on extreme learning machine and Lévy flight bat algorithm
Authors: Chen Youliang , Zhang Xiangjun , Karimian Hamed , Xiao Gang , Huang Jinsong 
Published: July 2021

Abstract
Dam deformation monitoring and prediction are crucial for evaluating the safety of reservoirs. There are several elements that influence dam deformation. However, the mixed effects of these elements are not always linear. Oppose to a single-kernel extreme learning machine, which suffers from poor generalization performance and instability, in this study, we proposed an improved bat algorithm for dam deformation prediction based on a hybrid-kernel extreme learning machine. To improve the learning ability of the global kernel and the generalization ability of the local kernel, we combined the global kernel function (polynomial kernel function) and local kernel function (Gaussian kernel function). Moreover, a Lévy flight bat optimization algorithm (LBA) was proposed to overcome the shortages of bat algorithms. The results showed that our model outperformed other models. This proves that our proposed algorithm and methods can be used in dam deformation monitoring and prediction in different projects and regions.
Identification and characteristics analysis of Meiyu in Anhui Province based on the National Standard of Meiyu monitoring indices
Authors: Zhou Yuliang , Zuo Yilin , Zhang Yuliang , Jin Juliang , Zhou Ping , Wu Chengguo , Cui Yi , Ning Shaowei 
Published: July 2021

Abstract
Meiyu is the term used to depict the consecutive rainy weather advancing in the months before the flooding season in East Asia. However, the temporal-spatial climatic characteristics of Meiyu can be differently specified by different evaluation criteria. In this study, we employ both the atmospheric circulation conditions and meteorological factors to identify the spatial characteristics of precipitation of Meiyu in Anhui Province using the collected data of 1957–2020. We further conduct a comparison analysis of the precipitation characteristics in the northern Huaihe River of Aihui province (NHA) with Meiyu rainfall features in two other regions: south of the Yangtze River in Anhui Province (SYA) and the region between the Yangtze River and Huaihe River in Anhui Province (YHA). Finally, the relation between the intensity index between Meiyu and flood or drought is investigated. The results showed that the climatic feature in NHA is a transitional region between Meiyu and non-Meiyu. Also, we proposed a Meiyu intensity index determined by the precipitation amount, intensity, and days of heavy rain. This index performs better than the Meiyu intensity index of National Standard in terms of flood and drought identification.
Tracking antibiotic resistance genes and class 1 integrons in Escherichia coli isolates from wastewater and agricultural fields
Authors: Shamsizadeh Zahra , Ehrampoush Mohammad Hassan , Nikaeen Mahnaz , Mokhtari Mehdi , Rahimi Mahsa , Khanahmad Hossein , Mohammadi Farzaneh 
Published: July 2021

Abstract
Considering high concentrations of multidrug-resistant bacteria and antibiotic resistance genes (ARGs) in wastewater, agricultural reuse of treated wastewater may be a public health threat due to ARG dissemination in different environmental compartments, including soil and edible parts of crops. We investigated the presence of antibiotic-resistant Escherichia coli as an indicator bacterium from secondary treated wastewater (STWW), water- or wastewater-irrigated soil and crop samples. ARGs including blaCTX-m-32, blaOXA-23, tet-W, sul1, cml-A, erm-B, along with intI1 gene in E. coli isolates were detected via molecular methods. The most prevalent ARGs in 78 E. coli isolates were sul1 (42%), followed by blaCTX-m-32 (19%), and erm-B (17%). IntI1 as a class 1 integrons gene was detected in 46% of the isolates. Cml-A was detected in STWW isolates but no E. coli isolate from wastewater-irrigated soil and crop samples contained this gene. The results also showed no detection of E. coli in water-irrigated soil and crop samples. Statistical analysis showed a correlation between sul1 and cml-A with intI1. The results suggest that agricultural reuse of wastewater may contribute to the transmission of antibiotic-resistant bacteria to soil and crop. Further research is needed to determine the potential risk of ARB associated with the consumption of wastewater-irrigated crops.
Analysis of potential of Napier grass, Vetiver and Equisetum plants for the treatment of domestic greywater using box-type constructed wetlands
Authors: MR Sijimol , ML Mansa , Joseph Sabu 
Published: July 2021

Abstract
The management of wastewater generated as a byproduct of various human activities from agricultural, industrial, and domestic sectors is a matter of global concern today. Greywater is a class of wastewater generated from the domestic sector. Greywater management can be done effectively by treating greywater at the source itself. In this context, constructed wetlands (CWs) come handy with low-tech, environmental, and economic-friendly options. In the present study, box-type horizontal subsurface flow constructed wetlands were designed and the efficiency of Napier grass (Pennisetum purpureum), Vetiver (Vetiveria zizanioides), and Equisetum (Equisetum hyemale) were assessed in treating domestic greywater. There was a drastic significant increase in DO with 47.0% in Vetiver, 92.5% in Napier grass, and 97.2% in Equisetum. The average percent pollutant removal of some major parameters was 92.4% for turbidity, 92.7% for acidity, 81.3% for BOD, 91.0% for COD with Napier grass. In the case of Vetiver, the removal percent was 82.5% turbidity, 87.9% acidity, 81.8% BOD, and 92.9% COD. For Equisetum, the average pollutant removal efficiency varied with 94.6% turbidity, 91.4% acidity, 80.0% BOD, and 88.1%COD. The study thus proves the efficiency of all the three plants to be used in box-type constructed wetlands.