bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonparametric extrapolation of extreme quantiles: a comparison study
Authors: Banfi Fabiola , Cazzaniga Greta , De Michele Carlo 
Published: October 2021

AbstractThe extrapolation of quantiles beyond or below the largest or smallest observation plays an important role in hydrological practice, design of hydraulic structures, water resources management, or risk assessment. Traditionally, extreme quantiles are obtained using parametric methods that require to make an a priori assumption about the distribution that generated the data. This approach has several limitations mainly when applied to the tails of the distribution. Semiparametric or nonparametric methods, on the other hand, allow more flexibility and they may overcome the problems of the parametric approach. Therefore, we present here a comparison between three selected semi/nonparametric methods, namely the methods of Hutson (Stat and Comput, 12(4):331–338, 2002) and Scholz (Nonparametric tail extrapolation. Tech. Rep. ISSTECH-95-014, Boeing Information and Support Services, Seattle, WA, United States of America, 1995) and kernel density estimation. While the first and third methods have already applications in hydrology, Scholz (Nonparametric tail extrapolation. Tech. Rep. ISSTECH-95-014, Boeing Information and Support Services, Seattle, WA, United States of America, 1995) is proposed in this context for the first time. After describing the methods and their applications in hydrology, we compare their performance for different sample lengths and return periods. We use synthetic samples extracted from four distributions whose maxima belong to the Gumbel, Weibull, and Fréchet domain of attraction. Then, the same methods are applied to a real precipitation dataset and compared with a parametric approach. Eventually, a detailed discussion of the results is presented to guide researchers in the choice of the most suitable method. None of the three methods, in fact, outperforms the others; performances, instead, vary greatly with distribution type, return period, and sample size.
Deprescribing in palliative patients with cancer: a concise review of tools and guidelines
Authors: van Merendonk Lisanne N. , Crul Mirjam 
Published: October 2021

Abstract
Purpose
Palliative cancer patients can benefit from deprescribing of potentially inappropriate medications (PIMs). Tools and guidelines developed for the geriatric population are mainly available. This systematic review gives an overview of available guidelines and tools to deprescribe for palliative cancer patients.

Methods
A systematic search was carried out using the databases SCOPUS and PubMed. Studies focused on palliative cancer patients were included.

Results
The search identified 137 studies of which 15 studies were included in this systematic review. Six of the included tools were developed specifically for cancer patients. One of these tools was externally validated and applied in several studies and settings. Guidelines or tools that were not specifically developed for cancer patients but that were applied on cohorts of palliative cancer patients were also included.

Conclusion
Tools developed for geriatric patients contain drugs that are not inappropriate when used in the palliative cancer care setting. Tools developed for cancer patients are more suitable and can be applied in combination with stepwise methods to individualize deprescribing per patient. The tools and guidelines described in this systematic review can be used to further implement deprescribing in the clinical routine for palliative cancer patients.
A review of trauma and orthopaedic randomised clinical trials published in high-impact general medical journals
Authors: Farrow Luke , Gardner William T. , Ablett Andrew D. , Kutuzov Vladislav , Johnstone Alan 
Published: October 2021

Abstract
Introduction
The recent past has seen a significant increase in the number of trauma and orthopaedic randomised clinical trials published in “the big five” general medical journals. The quality of this research has, however, not yet been established.

Methods
We therefore set out to critically appraise the quality of available literature over a 10-year period (April 2010–April 2020) through a systematic search of these 5 high-impact general medical journals (JAMA, NEJM, BMJ, Lancet and Annals). A standardised data extraction proforma was utilised to gather information regarding: trial design, sample size calculation, results, study quality and pragmatism. Quality assessment was performed using the Cochrane Risk of Bias 2 tool and the modified Delphi list. Study pragmatism was assessed using the PRECIS-2 tool.

Results
A total of 25 studies were eligible for inclusion. Over half of the included trials did not meet their sample size calculation for the primary outcome, with a similar proportion of these studies at risk of type II error for their non-significant results. There was a high degree of pragmatism according to PRECIS-2. Non-significant studies had greater pragmatism that those with statistically significant results (p < 0.001). Only 56% studies provided adequate justification for the minimum clinically important difference (MCID) in the population assessed. Overall, very few studies were deemed high quality/low risk of bias.

Conclusions
These findings highlight that there are some important methodological concerns present within the current evidence base of RCTs published in high-impact medical journals. Potential strategies that may improve future trial design are highlighted.

Level of evidence
Level 1.
Microscale size effects in piezomagnetic material for the anti-plane problem
Authors: Xu Mingxiu , Askes Harm , Shang Xinchun , Gitman Inna M. 
Published: October 2021

AbstractA continuum model of piezomagnetic material with strain, magnetic and piezomagnetic coupling gradient effects is proposed using a variational principle in this work. This model is employed to an anti-plane problem, and a general solution is constructed in polar coordinates. Special attention is paid to microstructural effects on the magnetic and mechanical response in an infinite piezomagnetic medium with a void. It is found that the microstructural length scales have a significant influence on the mechanic and magnetic fields. The three length scales (corresponding to strain, magnetic and piezomagnetic coupling gradients) are indispensable to describe the nonlocal effects of piezomagnetism. Additionally, controlling the direction and magnitude of the magnetic field at the edge of the void can be achieved by adjusting the microstructural length scales of the piezomagnetic medium.
Drivers of immersive virtual reality adoption intention: a multi-group analysis in chemical industry settings
Authors: Toyoda Ryo , Russo Abegão Fernando , Gill Sue , Glassey Jarka 
Published: October 2021

AbstractThe present study uses the modified Unified Theory of Acceptance and Use of Technology 2 to examine the effect of factors such as performance expectancy (PE), effort expectancy (EE), social influence (SI), and hedonic motivation (HM) that may motivate operators and employees to adopt IVR-based technology into their training. Results of a multi-group analysis based on nationality, prior IVR experience, and/or length of work experience, to analyse the potential similarities and/or differences in perception and acceptance towards using IVR-based technology are also presented. The quantitative research data were gathered using an online questionnaire from 438 chemical operators and/or employees who either speak German, French, or English. Partial least squares structural equation modelling and multi-group analysis based on SmartPLS™ version 3 were used to carry out the path and multi-group analyses. The results show that the behavioural intention (BI) towards adoption of IVR was influenced by PE, EE, and HM for all abovementioned subpopulation. However, the relationship of SI to BI was not supported for respondents with prior IVR experience and for respondents coming from Western region. Although Henseler’s-based multi-group PLS analysis reveals that there was no significant difference between the group comparisons, it is still important to take into account these socio-demographic factors as there are definite group differences in terms of the ranking order of each construct for the IVR adoption intentions among each subpopulation. The implications and future directions were discussed.
Now you see it, now you don’t: dynamism amplifies the typicality effect
Authors: Clewley Richard , Nixon Jim 
Published: October 2021

AbstractSome safety events do not stabilise in a coherent state, presenting with transient or intermittent features. Such dynamism may pose problems for human performance, especially if combined with non-typical stimuli that are rarely encountered in everyday work. This may explain undesirable pilot behaviour and could be an important cognitive factor in recent aircraft accidents. Sixty-five airline pilots tested a real-world typicality gradient, composed of two cockpit events, a typical event, and a non-typical event, across two different forms of dynamism, a stable, single system transition, and an unstable, intermittent system transition. We found that non-typical event stimuli elicited a greater number of response errors and incurred an increased response latency when compared to typical event stimuli, replicating the typicality effect. These performance deteriorations were amplified when a form of unstable system dynamism was introduced. Typical stimuli were unaffected by dynamism. This indicates that dynamic, non-typical events are problematic for pilots and may lead to poor event recognition and response. Typical is advantageous, even if dynamic. Manufacturers and airlines should evolve pilot training and crew procedures to take account of variety in event dynamics.
Preoperative brain shift is a prognostic factor for survival in certain neurosurgical diseases other than severe head injury: a case series and literature review
Authors: Missori Paolo , La Torre Giuseppe , Lazzari Susanna , Paolini Sergio , Peschillo Simone , Martini Stefano , Palmarini Valeria 
Published: October 2021

AbstractPreoperative brain shift after severe brain injury is a prognostic factor for survival. The aim of this study was to determine whether preoperative brain shift in conditions other than severe head injury has significant prognostic value. We analyzed a radiological database of 800 consecutive patients, who underwent neurosurgical treatment. Brain shift was measured at two anatomical landmarks: Monro’s foramina (MF) and the corpus callosum (CC). Four hundred seventy-three patients were included. The disease exerting the highest mean brain shift was acute subdural hematoma (MF 11.6 mm, CC 12.4 mm), followed by intraparenchymal hematoma (MF 10.2 mm, CC 10.3 mm) and malignant ischemia (MF 10.4 mm, CC 10.5 mm). On univariate analysis, brain shift was a significant negative factor for survival in all diseases (p < 0.001). Analyzed individually by group, brain shift at both anatomical landmarks had a statistically significant effect on survival in malignant ischemia and at one anatomical landmark in chronic subdural and intraparenchymal hematomas. Multivariate analysis demonstrated that the only independent factor negatively impacting survival was brain shift at MF (OR = 0.89; 95% CI: 0.84–0.95) and CC (OR = 0.90; 95% CI: 0.85–0.96). Brain shift is a prognostic factor for survival in patients with expansive intracranial lesions in certain neurosurgical diseases. MF and CC are reliable anatomical landmarks and should be quoted routinely in radiological reports as well as in neurosurgical practice.
Barriers and wellbeing-oriented enablers of intergenerational innovation in the digital age
Authors: Nurhas Irawan , Geisler Stefan , Ojala Arto , Pawlowski Jan M. 
Published: October 2021

AbstractSo far, researchers have used a wellbeing-centered approach to catalyze successful intergenerational collaboration (IGC) in innovative activities. However, due to the subject’s multidisciplinary nature, there is still a dearth of comprehensive research devoted to constructing the IGC system. Thus, the purpose of this study is to fill a research void by providing a conceptual framework for information technology (IT) system designers to use as a jumping-off point for designing an IGC system with a wellbeing-oriented design. A systematic literature study was conducted to identify relevant terms and develop a conceptual framework based on a review of 75 selected scientific papers. The result consists of prominent thematic linkages and a conceptual framework related to design technology for IGC systems. The conceptual framework provides a comprehensive overview of IGC systems in the innovation process by identifying five barrier dimensions and using six wellbeing determinants as IGC catalysts. Moreover, this study discusses future directions for research on IGC systems. This study offers a novel contribution by shifting the technology design process from an age-based design approach to wellbeing-driven IGC systems. Additional avenues for investigation were revealed through the analysis of the study’s findings.
Poland’s stance on CAI: no need for haste
Authors: Szczudlik Justyna 
Published: October 2021

AbstractPoland was among vocal critics of the acceleration and finalization of CAI talks by the end of 2020. Among the reasons
were doubts about the timing and political circumstances in the EU such as the role of Germany as a driving force for CAI due to its economic dependence on China, and Commission mandate for talks that was granted several years ago in a very different situation both in China and Europe. Poland was also critical about bypassing the USA, in a sense of bringing CAI talks up to speed during the transition period, before Biden sworn. However, after finalization of the agreement, Polish government (as well as the biggest opposition party) presents a rather positive assessment of CAI and opts for ratification. Notwithstanding, all Polish MEPs have endorsed the European Parliament resolution to freeze ratification process.
Akut symptomatische Anfälle und die Abgrenzung zum Status epilepticus auf der Intensivstation bei Kindern und Erwachsenen
Authors: Leitinger Markus 
Published: October 2021

ZusammenfassungAkut symptomatische Anfälle (ASA) finden sich häufig an pädiatrischen und neurologischen Intensivstationen. Während bei Vorliegen einer fassbaren Semiologie die Erkennung klinisch gelingt, bedarf es für elektrographische Anfälle präziser Kriterien, welche von der Amerikanischen Klinischen Neurophysiologischen Gesellschaft (ACNS) kürzlich in einer aktualisierten Form publiziert wurden. Neue Aspekte sind hierbei die Beschreibung von kurzen potenziell iktalen rhythmischen Entladungen („brief potentially ictal rhythmic discharges“ [BIRDs]) sowie die Beschreibung des Iktal-Interiktalen-Kontinuums (IIC). Die Interpretation der elektroenzephalographischen (EEG) Kriterien erfolgt im Idealfall in einem interdisziplinären Zugang zwischen der Neurophysiologie und der Intensivmedizin. Die Korrelation von Anfallslast mit Verschlechterung des neurologischen Outcomes ist in Studien an pädiatrischen bzw. neurologischen Intensivstationen belegt.
One Dimensional Reduction of a Renewal Equation for a Measure-Valued Function of Time Describing Population Dynamics
Authors: Franco Eugenia , Gyllenberg Mats , Diekmann Odo 
Published: October 2021

AbstractDespite their relevance in mathematical biology, there are, as yet, few general results about the asymptotic behaviour of measure valued solutions of renewal equations on the basis of assumptions concerning the kernel. We characterise, via their kernels, a class of renewal equations whose measure-valued solution can be expressed in terms of the solution of a scalar renewal equation. The asymptotic behaviour of the solution of the scalar renewal equation, is studied via Feller’s classical renewal theorem and, from it, the large time behaviour of the solution of the original renewal equation is derived.
Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma
Authors: Kam Ngar Woon , Wu Ka Chun , Dai Wei , Wang Ying , Yan Leo Yik Chun , Shakya Reshma , Khanna Rajiv , Qin Yanru , Law Simon , Lo Anthony Wing Ip , Lee Victor Ho Fun , Guan Xin-Yuan , Kwong Dora Lai-Wan 
Published: October 2021

AbstractSeveral B-cell subsets with distinct functions and polarized cytokine profiles that extend beyond antibody production have been reported in different cancers. Here we have demonstrated that proliferating B cells were predominantly found in the peritumoral region of esophageal squamous cell carcinoma (ESCC). These B cells were enriched in tumor nests with high expression of high-mobility group box 1 (HMGB1). High densities of peritumoral proliferating B cells and concomitantly high intratumoral HMGB1 expression showed improved prognostic significance, surpassing prognostic stratification of ESCC patients based on HMGB1 positivity alone. This striking association led us to set up models to test whether cancer-derived HMGB1 could shape tumor microenvironment via modulation on B cells. Overexpression of HMGB1 in ESCC cell lines (KYSE510 and EC18) enhanced proliferation and migration of B cells. Transcriptomic analysis showed that migratory B cells exhibited high enrichment of proangiogenic genes. VEGF expression in proliferating B cells was induced upon co-culture of HMGB1-overexpressing tumor cells and B cells. Secretome array profiling of conditioned media (CM) from the co-culture revealed rich expression of proangiogenic proteins. Consequently, incubation of human umbilical vein endothelial cells with CM promoted angiogenesis in tube formation and migration assays. HMGB1 inhibitor, glycyrrhizin, abolishes all the observed proangiogenic phenotypes. Finally, co-injection of B cells and CM with HMGB1-overexpressing tumor cells, but not with glycyrrhizin, significantly enhanced tumor growth associated with increased microvascular density in ESCC xenograft mice model. Our results indicate that cancer-derived HMGB1 elevates angiogenesis in ESCC by shifting the balance toward proangiogenic signals in proliferating B cells.
Numerical differentiation on scattered data through multivariate polynomial interpolation
Authors: Dell’Accio Francesco , Di Tommaso Filomena , Siar Najoua , Vianello Marco 
Published: October 2021

AbstractWe discuss a pointwise numerical differentiation formula on multivariate scattered data, based on the coefficients of local polynomial interpolation at Discrete Leja Points, written in Taylor’s formula monomial basis. Error bounds for the approximation of partial derivatives of any order compatible with the function regularity are provided, as well as sensitivity estimates to functional perturbations, in terms of the inverse Vandermonde coefficients that are active in the differentiation process. Several numerical tests are presented showing the accuracy of the approximation.
Molecular implications of HOX genes targeting multiple signaling pathways in cancer
Authors: Shenoy U Sangeetha , Adiga Divya , Kabekkodu Shama Prasada , Hunter Keith D , Radhakrishnan Raghu 
Published: October 2021

AbstractHomeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.
Graphical abstract
On the Tightness of Semidefinite Relaxations for Rotation Estimation
Authors: Brynte Lucas , Larsson Viktor , Iglesias José Pedro , Olsson Carl , Kahl Fredrik 
Published: October 2021

AbstractWhy is it that semidefinite relaxations have been so successful in numerous applications in computer vision and robotics for solving non-convex optimization problems involving rotations? In studying the empirical performance, we note that there are few failure cases reported in the literature, in particular for estimation problems with a single rotation, motivating us to gain further theoretical understanding. A general framework based on tools from algebraic geometry is introduced for analyzing the power of semidefinite relaxations of problems with quadratic objective functions and rotational constraints. Applications include registration, hand–eye calibration, and rotation averaging. We characterize the extreme points and show that there exist failure cases for which the relaxation is not tight, even in the case of a single rotation. We also show that some problem classes are always tight given an appropriate parametrization. Our theoretical findings are accompanied with numerical simulations, providing further evidence and understanding of the results.
The Use of Children as a Tactic of Intimate Partner Violence and its Relationship to Survivors’ Mental Health
Authors: Clements Kathryn A. V. , Sprecher Mackenzie , Modica Sydney , Terrones Michelle , Gregory Katie , Sullivan Cris M. 
Published: October 2021

AbstractAlthough prior research has established that intimate partner violence (IPV) often leads to increased depression, anxiety and post-traumatic stress disorder (PTSD), little is known about how often abusive partners and ex-partners use survivors’ children as an abuse tactic, nor whether this form of IPV also is detrimental to survivors’ mental health. The current study interviewed 299 unstably housed survivors of intimate partner violence shortly after they sought services from a domestic violence agency. All participants were parents of minor children. In-person interviews asked about abuse experienced in the prior six months, including the ways children were used as a form of IPV. Participants were also asked about their current depression, anxiety, and symptoms of PTSD. As hypothesized, the majority of parents reported their abusive partners and ex-partners had used their children as a form of IPV to control and hurt them. Further, after controlling for other forms of IPV, use of the children significantly predicted both increased anxiety and greater number of PTSD symptoms. Results show the importance of focusing on the use of children as a common and injurious form of abuse used against survivors of intimate partner violence (IPV).