bluuebunny/crossref_metadata_2025_split huggingface dataset:
An evaluation of family-based treatment for restrictive-type eating disorders, delivered as standard care in a public mental health service
Authors: Bentz Mette , Pedersen Signe Holm , Moslet Ulla 
Published: October 2021

Abstract
Background
Family-based treatment (FBT) has demonstrated efficacy for anorexia nervosa (AN) in youth in randomized, controlled trials. It is important to assess if it shows a similar effectiveness when implemented in standard care.

Aim
To evaluate outcomes of FBT for restrictive-type eating disorders, delivered as standard care in a public mental health service. Outcomes are remission, frequency of hospital admissions and day-patient treatment, and frequency of other adaptations within 12 months from commencement of treatment. Second, to compare the collaborative clinical decisions of successful treatment in standard care made by family therapist at the end of treatment, with more objective definitions of recovery.

Methods
The design is a prospective, uncontrolled study of a consecutive series of patients with restrictive-type eating disorders, treated with FBT in a specialty unit at the Child and Adolescent Mental Health Centre in the Capital Region of Denmark.

Results
FBT was successfully completed within 12 months by 57% of participants, and 47% completed with 20 sessions or fewer. Weight restoration was achieved by 75% within 12 months, and 46% achieved both normalisation of body weight and behavioural symptoms of AN within 12 months. A total of 20% needed intensified treatment. All aspects of remission were often not present simultaneously, and the collaborative clinical decisions of successful treatment only partly aligned with other parameters of remission.

Conclusion
FBT showed good results when implemented as standard care, and it can be adapted to the specifics of local service organisation without compromising effectiveness.
Co-expression of mesothelin and CA125/MUC16 is a prognostic factor for breast cancer, especially in luminal-type breast cancer patients
Authors: Einama Takahiro , Yamagishi Yoji , Takihata Yasuhiro , Suzuki Takafumi , Yamasaki Tamio , Hirose Yuichi , Kobayashi Kazuki , Yonamine Naoto , Fujinuma Ibuki , Tsunenari Takazumi , Koga Makiko , Ishibashi Yusuke , Nagata Ken , Shiraishi Takehiro , Nakazawa Akiko , Iwasaki Toshimitsu , Shinto Eiji , Kato Kimi , Sato Kimiya , Ueno Hideki , Kishi Yoji , Tsuda Hitoshi 
Published: October 2021

AbstractThe expression of mesothelin correlates with a poor prognosis in patients with breast cancer. Since mesothelin plays a role in cancer metastasis in association with CA125, we herein examined the expression of mesothelin and CA125, and the clinicopathological meaning and prognosis of the co-expression of mesothelin and CA125 in breast cancer. Our results showed that among 478 patients, mesothelin and CA125 were co-expressed in 48 (10 %), mesothelin only in 75 (16 %), CA125 only in 217 (45 %), and neither in 234 (49 %). A high correlation was observed between the expression of mesothelin and CA125 (P =0.0004). The co-expression of mesothelin and CA125 correlated with poor patient relapse-free survival (RFS) (P = 0.0001) and was identified as an independent predictor of RFS by Cox’s multivariate analysis. In conclusion, this is the first to report the prognostic significance of the co-expression of mesothelin and CA125 in breast cancer. The co-expression of mesothelin and CA125 may be clinically useful for prognostication after surgical therapy in patients with breast cancer.
Cost-effectiveness analysis of a large-scale crèche intervention to prevent child drowning in rural Bangladesh
Authors: Alfonso Y. Natalia , Hyder Adnan A. , Alonge Olakunle , Salam Shumona Sharmin , Baset Kamran , Rahman Aminur , Hoque Dewan Md Emdadul , Islam Md Irteja , Rahman Fazlur , El-Arifeen Shams , Bishai David 
Published: October 2021

Abstract
Background
Drowning is the leading cause of death among children 12–59 months old in rural Bangladesh. This study evaluated the cost-effectiveness of a large-scale crèche (daycare) intervention in preventing child drowning.

Methods
The cost of the crèches intervention was evaluated using an ingredients-based approach and monthly expenditure data collected prospectively throughout the study period from two agencies implementing the intervention in different study areas. The estimate of the effectiveness of the crèches intervention was based on a previous study. The study evaluated the cost-effectiveness from both a program and societal perspective.

Results
From the program perspective the annual operating cost of a crèche was $416.35 (95% CI: $221 to $576), the annual cost per child was $16 (95% CI: $8 to $23), and the incremental-cost-effectiveness ratio (ICER) per life saved with the crèches was $17,008 (95% CI: $8817 to $24,619). From the societal perspective (including parents time valued) the ICER per life saved was − $166,833 (95% CI: − $197,421 to − $141,341)—meaning crèches generated net economic benefits per child enrolled. Based on the ICER per disability-adjusted-life years averted from the societal perspective (excluding parents time), $1978, the crèche intervention was cost-effective even when the societal economic benefits were ignored.

Conclusions
Based on the evidence, the crèche intervention has great potential for generating net societal economic gains by reducing child drowning at a program cost that is reasonable.
Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex
Authors: Valind Kristian , Jögi Jonas , Minarik David , Brolin Gustav , Trägårdh Elin 
Published: October 2021

Abstract
Background
In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.

Methods
Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality.

Results
Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%).

Conclusions
Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy.
Ergothioneine supplementation in people with metabolic syndrome (ErgMS): protocol for a randomised, double-blind, placebo-controlled pilot study
Authors: Tian Xiaoying , Cioccoloni Giorgia , Sier Joanna H. , Naseem Khalid M. , Thorne James L. , Moore J. Bernadette 
Published: October 2021

Abstract
Background
Ergothioneine is a naturally occurring metabolite of histidine found in many foods and in high amounts in mushrooms. In vivo, ergothioneine acts as an antioxidant and is widely distributed in most mammalian tissues. While ergothioneine is sold as a dietary supplement for its antioxidant and anti-inflammatory properties, to date there are no published intervention trials examining its health benefits in humans. The aim of this work was to develop a study protocol for a pilot interventional trial that will establish the primary and secondary outcomes, and the power required, for a definitive randomised controlled trial to test the hypothesis that ergothioneine supplementation is beneficial for people with metabolic syndrome.

Methods
We have designed the ErgMS study as a single-centre, randomised, double-blind, placebo-controlled, 3-arm parallel, pilot intervention trial, which aims to supplement participants with either placebo, 5 or 30 mg/day ergothioneine for 12 weeks. Measurements of metabolic syndrome risk factors, serum markers of oxidative stress (lipid peroxidation), inflammation, blood platelet function and liver function will take place at baseline, and after 6 weeks and 12 weeks of supplementation. In addition, we will examine if there are any changes in the serum metabolome in response to ergothioneine supplementation. Linear regression and two-way ANOVA will be utilised to analyse the association between ergothioneine and measured variables.

Discussion
The ErgMS study will be the first study to address the question does ergothioneine supplementation have health benefits for people with metabolic syndrome. Study results will provide preliminary data as to which dose may improve inflammatory markers in adults with metabolic syndrome and will inform dose and primary outcome selection for a definitive randomised controlled trial.

Trial registration
ISRCTN, ISRCTN25890011 Registered February 10th, 2021
Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations
Authors: Rungkitwattanakul Dhakrit , Charoensareerat Taniya , Kerdnimith Pathakorn , Kosumwisaisakul Nutsinee , Teeranaew Piyakamol , Boonpeng Apinya , Pattharachayakul Sutthiporn , Srisawat Nattachai , Chaijamorn Weerachai 
Published: October 2021

Abstract
Background
The appropriate dosing of imipenem for critically ill AKI patients undergoing CRRT remains scarce.

Purpose
This study aimed to (1) gather the available published pharmacokinetic studies conducted in septic patients receiving continuous renal replacement therapy (CRRT) and (2) to define the optimal imipenem dosing regimens in these populations via Monte Carlo simulations.

Methods
The databases of PubMed, Embase, and ScienceDirect were searched from inception to May 2020. We used the Medical Subject Headings of “Imipenem,” “CRRT,” and “pharmacokinetics” or related terms or synonym to identify the studies for systematic reviews. A one-compartment pharmacokinetic model was conducted to predict imipenem levels for the initial 48 h of therapy. The pharmacodynamic target was 40% of free drug level above 4 times of the MIC (40% fT > 4 MIC). The dose that achieved at least 90% of the probability of target attainment was defined as an optimal dose.

Results
Eleven articles were identified and included for our systematic review. The necessary pharmacokinetic parameters such as the volume of distribution and the CRRT clearance were mentioned in 100 and 90.9%, respectively. None of the current studies reported the complete necessary parameters. A regimen of 750 mg q 6 h was the optimal dose for the predilution-CVVH and CVVHD modality with two effluent rates (25 and 35 mL/kg/h) for the pharmacodynamic target of 40% fT > 4MIC.

Conclusions
None of the current studies showed the complete necessary pharmacokinetic parameters for drug dosing. Pharmacodynamic target significantly contributed to imipenem dosing regimens in these patients. Different effluent rates and types of CRRT had minimal impact on dosing regimens. Clinical validation of the recommendation is necessary.
Examining data visualization pitfalls in scientific publications
Authors: Nguyen Vinh T , Jung Kwanghee , Gupta Vibhuti 
Published: October 2021

AbstractData visualization blends art and science to convey stories from data via graphical representations. Considering different problems, applications, requirements, and design goals, it is challenging to combine these two components at their full force. While the art component involves creating visually appealing and easily interpreted graphics for users, the science component requires accurate representations of a large amount of input data. With a lack of the science component, visualization cannot serve its role of creating correct representations of the actual data, thus leading to wrong perception, interpretation, and decision. It might be even worse if incorrect visual representations were intentionally produced to deceive the viewers. To address common pitfalls in graphical representations, this paper focuses on identifying and understanding the root causes of misinformation in graphical representations. We reviewed the misleading data visualization examples in the scientific publications collected from indexing databases and then projected them onto the fundamental units of visual communication such as color, shape, size, and spatial orientation. Moreover, a text mining technique was applied to extract practical insights from common visualization pitfalls. Cochran’s Q test and McNemar’s test were conducted to examine if there is any difference in the proportions of common errors among color, shape, size, and spatial orientation. The findings showed that the pie chart is the most misused graphical representation, and size is the most critical issue. It was also observed that there were statistically significant differences in the proportion of errors among color, shape, size, and spatial orientation.
Botulinum toxin injections as salvage therapy is beneficial for management of patellofemoral pain syndrome
Authors: Kesary Yuval , Singh Vivek , Frenkel-Rutenberg Tal , Greenberg Arie , Dekel Shmuel , Schwarzkopf Ran , Snir Nimrod 
Published: October 2021

Abstract
Purpose
Patellofemoral pain syndrome (PFPS) is a common pathology usually presenting with anterior or retropatellar pain. It is associated with a relative imbalance between the vastus medialis oblique (VMO) and the vastus lateralis (VL) muscles. This can lead to considerable morbidity and reduced quality of life (QOL). This study aims to assess the long-term functional outcome of PFPS treated with VL muscle botulinum toxin A (BoNT-A) injection.

Materials and methods
A retrospective review was performed on 26 consecutive patients (31 knees) with a mean age of 50.1 years (± 19.7 years) who were treated with BoNT-A injections to the VL muscle followed by physiotherapy between 2008 and 2015. Pre- and post-treatment pain levels (numerical rating scale, NRS), QOL (SF-6D), and functional scores (Kujala and Lysholm questionnaires) were measured. Demographics, physical therapy compliance, previous surgeries, perioperative complications, and patient satisfaction levels were collected.

Results
The mean follow-up time was 58.8 ± 36.4 months. There were significant improvements in all the examined domains. The average pain score (NRS) decreased from 7.6 to 3.2 (P < 0.01), and the Kujala, Lysholm, and SF-6D scores improved from 58.9 to 82.7 (P < 0.001), 56.2 to 83.2 (P < 0.001), and 0.6 to 0.8 (P < 0.001), respectively. Similar delta improvement was achieved irrespective of gender, age, compliance to post-treatment physical therapy, or coexisting osteoarthritis. Patients who presented with a worse pre-treatment clinical status achieved greater improvement. Prior to BoNT-A intervention, 16 patients (18 knees) were scheduled for surgery, of whom 12 (75%, 13 knees) did not require further surgical intervention at the last follow-up.

Conclusions
A single intervention of BoNT-A injections to the VL muscle combined with physiotherapy is beneficial for the treatment of patients with persistent PFPS.

Level III evidence
Retrospective cohort study.
Influence of tobacco cigarette heavy smoking on DNA methylation patterns and transcription levels of MAPK8IP3, GAA, ANXA2, PRRC2A, and PDE11A genes in human spermatozoa
Authors: Laqqan Mohammed M. , Yassin Maged M. 
Published: October 2021

Abstract
Background
Tobacco smoking is considered as one of the lifestyles factors that influence the sperm DNA methylation and global sperm DNA methylation and that may affect the sperm phenotype. This study was performed to investigate whether tobacco cigarette heavy smoking influences sperm DNA methylation patterns and semen parameters and to determine whether there is an alteration in the transcription level of MAPK8IP3, GAA, ANXA2, PRRC2A, and PDE11A genes in heavy smokers compared to non-smokers. Thirty samples were subjected to 450K arrays as a screening study to assess the variation in sperm DNA methylation levels between heavy smokers and non-smokers. Five CpG sites have the highest difference in methylation levels (cg07869343, cg05813498, cg09785377, cg06833981, and cg02745784), which are located in the MAPK8IP3, GAA, ANXA2, PRRC2A, and PDE11A genes, respectively, and were selected for further analysis using deep bisulfite sequencing in 280 independent samples (120 proven non-smokers and 160 heavy smokers) with a mean age of 33.8 ± 8.4 years. The global sperm DNA methylation, sperm DNA fragmentation, and chromatin non-condensation were evaluated also.

Results
A significant increase was found in the methylation level at seven, three, and seventeen CpGs within the GAA, ANXA2, and MAPK8IP3 genes amplicon, respectively (P< 0.01) in heavy smokers compared to non-smokers. Additionally, a significant increase was found in the methylation levels at all CpGs within PRRC2A and PDE11A gene amplicon (P< 0.01). A significant increase was found in the level of sperm chromatin non-condensation, DNA fragmentation, and global DNA methylation (P < 0.001) in heavy smokers compared to non-smokers.

Conclusion
These results indicate that tobacco cigarette smoking can alter the DNA methylation level at several CpGs, the status of global DNA methylation, and transcription level of the following genes “MAPK8IP3, GAA, ANXA2, PRRC2A, and PDE11A” in human spermatozoa. These findings may affect negatively semen parameters and men’s fertility.
Vitamins and other immune-supportive elements as cofactors for passing the COVID-19 pandemic
Authors: Saeed Haitham , Osama Hasnaa , Abdelrahman Mona A. , Madney Yasmin M. , Harb Hadeer S. , Abdelrahim Mohamed E. A. , Ali Fatma 
Published: October 2021

Abstract
Background
Coronavirus disease 2019 (COVID-19) is a viral disease that causes a respiratory disorder, started in December of 2019 in China. Several vitamins and trace elements could help in enhancing host immunity producing antioxidant or anti-inflammatory action. This work aimed to identify the role of different nutrition, vitamins, and trace elements on the immunity status of the infected subject and the possibility of the beneficial role of these elements in the management of COVID-19.

Main body
After collecting (PubMed, scholar, OVID, Embase, Cochrane Library) and investigating published articles, testing the effect of these elements on viral infection, it was found that most of these elements have a significant role during viral infection through a different mechanism, like antioxidant, anti-inflammatory, and immunomodulation. Nutritional interventions in COVID-19 infections are very important currently, and it was reported that vitamin C and D reduce the risk of acute respiratory infections. In addition, low vitamin A diets compromise the effectiveness of inactivated bovine coronavirus vaccines. Administration of N-acetyl cysteine showed a beneficial inhibitory effect in viral infections and enhanced glutathione production. The deficiency of selenium on COVID-19 subjects has a significant impact on the clinical outcome of the subjects. In addition, supplementation with vitamins proved to enhance immune response during viral infection. Vitamins and trace elements not only showed a beneficial effect but also Omega 3 fatty acids showed an immunomodulating effect during infections.

Short conclusions
Assessment of levels for these trace elements at the baseline and providing supplementation containing different vitamins and elements could result in better control and clinical outcomes in the case of COVID-19.
Mycorrhizal impact on Ocimum basilicum grown under drought stress
Authors: Abd-Elghany Shaimaa E. , Moustafa Attaya A. , Gomaa Nasr H. , Hamed Badr-eldin A. 
Published: October 2021

AbstractBackgroundOcimum basilicumwas grown under three levels of drought stress (100% Field capacity, 70% Field capacity, and 40% Field capacity). Half of the plants were inoculated with Arbuscular mycorrhiza and the other half was not inoculated. Arbuscular mycorrhizal fungi (AMF) were applied to improve plant growth and to alleviate drought stress on sweet basil.ResultsDrought Couse inhibition in the colonization of Arbuscular mycorrhiza, reduction in plant growth, decrease stomatal size increase stomatal density, a decline in soluble carbohydrates, accumulation of amino acids, proline, and glycine betaine, and reduction in some minerals such as P, K, and Na.ConclusionsThe effect of drought was alleviated by the application of inoculation with Arbuscular mycorrhiza.
Detecting the nation-based characteristics of industries in the global input-output network of networks
Authors: An Feng , Wu Sen , Gao Xiangyun , Stanley H. Eugene 
Published: October 2021

Abstract
Under the influence of national policies, development plans, and subsidies, industries from the same nation perform similarly and inherit a part of their nations' characteristics. Unlike the one-layer input-output network that treats industries as isolated, our model treats industries from the same nation as a relative tight community. Thus, the characteristics of industries are inherited from their nation, which is defined as the nation-based characteristics. To accurately account for the nation-based contributions of each industry, we construct a global input-output NoN (network of networks) model. The global input-output NoN is transformed from the international input-output tables based on hypermatrices and the network of networks model. Based on the global input-output NoN, we propose six nation-based indexes to assess different aspects of industries' nation-based contributions. Our network model and nation-based indexes are applied on the international input-output tables from 2010 to 2015. We confirm the applicability of our model and discover several interesting findings. Overall, the most important one is that some nonmanufacturing industries (e.g., health, education, and public administration) may be more critical than some significant manufacturing industries.
Tokens of Love
Authors: Mascetti Yaakov A. 
Published: October 2021

AbstractThe third and final installment of this book-length contribution to the Common Knowledge symposium “Contextualism—the Next Generation” treats two further writers in seventeenth-century England whose work is not representative of any stance or discourse that contextualist historians have recognized as available in that era. In Aemelia Lanyer's poetry, we find a resistance to established perspectives that is related to her sense that divine signification is always incomplete and that, therefore, the diffidence of female cognition is superior, when approaching religious texts, to the assertive mentality that she associates with men. Despite his sex, however, and his reputation for theological and political radicalism, Milton too explicitly contends that the interpretation of scripture should always be “non-committal” because its signification is always incomplete. The “very magnitude” of the “great mystery” of the Incarnation, Milton argues in De Doctrina Christiana, should encourage the reader's mind to stand on “guard from the outset” against the tendency to make “rash or hasty assertions.” The urge to tamper with, pry into, add to, or hasten to understand the signifiers of divine meaning is shown, in Paradise Lost, to be the original sin of the first human couple. As much as for Lanyer, then, sex is for Milton bound up with hermeneutics—and, for both poets, the individual's relationship with God is a consuming passion, about which one may report a phenomenology of affects but can offer no contentions or arguments.