bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors that affect protein abundance of a positive regulator of abscisic acid signalling, the basic leucine zipper transcription factor ABRE‐binding factor 2 (ABF2)
Authors: Linden Katrina J. , Chen Yi‐Tze , Kyaw Khin , Schultz Brandan , Callis Judy 
Published: July 2021

AbstractMost members of basic leucine zipper (bZIP) transcription factor (TF) subgroup A play important roles as positive effectors in abscisic acid (ABA) signaling during germination and/or in vegetative stress responses. In multiple plant species, one member, ABA insensitive 5 (ABI5), is a major TF that promotes seed maturation and blocks early seeding growth in response to ABA. Other members, referred to as either ABRE‐binding factors (ABFs), ABRE‐binding proteins (AREBs), or D3 protein‐binding factors (DPBFs), are implicated as major players in stress responses during vegetative growth. Studies on the proteolytic regulation of ABI5, ABF1, and ABF3 in Arabidopsis thaliana have shown that the proteins have moderate degradation rates and accumulate in the presence of the proteasome inhibitor MG132. Exogenous ABA slows their degradation and the ubiquitin E3 ligase called KEEP ON GOING (KEG) is important for their degradation. However, there are some reported differences in degradation among subgroup A members. The conserved C‐terminal sequences (referred to as the C4 region) enhance degradation of ABI5 but stabilize ABF1 and ABF3. To better understand the proteolytic regulation of the ABI5/ABFs and determine whether there are differences between vegetative ABFs and ABI5, we studied the degradation of an additional family member, ABF2, and compared its in vitro degradation to that of ABI5. As previously seen for ABI5, ABF1, and ABF3, epitope‐tagged constitutively expressed ABF2 degrades in seedlings treated with cycloheximide and is stabilized following treatment with the proteasome inhibitor MG132. Tagged ABF2 protein accumulates when seedlings are treated with ABA, but its mRNA levels do not increase, suggesting that the protein is stabilized in the presence of ABA. ABF2 is also an in vitro ubiquitination substrate of the E3 ligase KEG and recombinant ABF2 is stable in keg lysates. ABF2 with a C4 deletion degrades more quickly in vitro than full‐length ABF2, as previously observed for ABF1 and ABF3, suggesting that the conserved C4 region contributes to its stability. In contrast to ABF2 and consistent with previously published work, ABI5 with C terminal deletions including an analogous C4 deletion is stabilized in vitro compared to full length ABI5. In vivo expression of an ABF1 C4 deletion protein appears to have reduced activity compared to equivalent levels of full length ABF1. Additional group A family members show similar proteolytic regulation by MG132 and ABA. Altogether, these results together with other work on ABI5 regulation suggest that the vegetative ABFs share proteolytic regulatory mechanisms that are not completely shared with ABI5.
Quest of Schiff bases as corrosion inhibitors: A first principle approach
Authors: Kaur Manpreet , Kaur Kulwinder , Kaur Harminder 
Published: July 2021

AbstractIn the present work, the corrosion inhibition activity of three Schiff bases benzylidene‐pyridine‐2‐yl‐amine (BPA), (4‐methylbenzylidene)‐pyridine‐2‐ylamine (4CH3‐BPA), and (4‐chloro‐benzylidene)‐pyridine‐2‐yl‐amine (4Cl‐BPA) was investigated using density functional theory (DFT) to study the relationship between electronic parameters and the corrosion inhibition activity. The global energy parameters such as EHOMO, ELUMO, ΔEgap, and Dipole moment (μ), electron involved between inhibitor and the metal atom (ΔN), and total energy of the inhibitor (T.E.) parameters were examined. A good correlation is observed between experimental and theoretical calculations. A new Schiff base with OH functional group (OH‐BPA) is designed, and all theoretical calculations were performed to study its potential to act as an anticorrosive material. The effect of the presence of OH functional group at different positions on corrosion inhibition activity is also investigated. The best corrosion inhibition activity is achieved by Schiff base with OH functional group at para position.
Longitudinal study indicating antecedent psychosocial vulnerability as predictor of anxiety disorders post‐treatment in people with head and neck cancer
Authors: Henry Melissa , Sargi Elyonora , Frenkiel Saul , Hier Michael , Zeitouni Anthony , Kost Karen , Mlynarek Alex , Black Martin , MacDonald Christina , Richardson Keith , Chartier Gabrielle , Sadeghi Nader , Rosberger Zeev 
Published: July 2021

AbstractObjectiveThis study aimed to: (1) determine the contribution of pre‐cancer psychosocial vulnerability as an independent predictor of anxiety disorder (AD) onset immediately post‐treatment in patients diagnosed with a first occurrence of head and neck cancer (HNC), controlling for sociodemographics and medical variables; and (2) estimate prevalence of AD and identify trajectories from the moment of diagnosis to the immediate post‐treatment (i.e., over a period of 3 months) in this population.MethodsTwo‐hundred twenty‐four consecutive patients (participation rate = 72%) newly diagnosed with a primary HNC were assessed with a structured clinical interview for a mental disorder, validated psychometric measures, and medical chart reviews.ResultsTwenty‐five percent of patients presented a lifetime AD, 19.4% within 2 weeks of HNC diagnosis, and 16.6% immediately post‐treatment; representing 26.7% of patients with AD at any timepoint from the moment of diagnosis to immediately post‐treatment. Patients were more likely to present an AD immediately post‐treatment when they: were diagnosed with advanced‐stage cancer (OR = 3.40, p = 0.006), presented a upon cancer diagnosis AD (OR = 2.45, p = 0.008) and/or experienced childhood abuse (OR = 1.96, p = 0.03).ConclusionsSeveral AD trajectories may arise when patients are diagnosed with primary HNC. Health professionals should address AD and screen for risk factors (i.e., advanced stage cancer, AD upon cancer diagnosis, history of childhood abuse) as early as possible to assure optimal mental health care in this vulnerable population.
Three‐channel electrical impedance spectroscopy for field‐scale root phenotyping
Authors: Peruzzo Luca , Liu Xiuwei , Chou Chunwei , Blancaflor Elison B. , Zhao Haijun , Ma Xue‐Feng , Mary Benjamin , Iván Veronika , Weigand Maximilian , Wu Yuxin 
Published: July 2021

AbstractElectrical impedance spectroscopy has long been considered a promising technique for noninvasive, in‐situ root investigation because of its sensitivity to anatomy and physiology. However, the complexity of the root system and its coupling with stem and soil have hindered the signal interpretation and methodological upscaling to field applications. This study addresses these key issues by introducing three‐channel acquisitions and their interpretation through Cole–Cole fitting. This solution could successfully decouple the impedance response of stem, roots, and soil, as well as provide convenient parametrization and comparison of their impedance signals. The methodological solution was tested on 80 wheat (Triticum aestivum L.) and 10 pecan [Carya illinoensis (Wangenh.) K. Koch] plants, the first extensive and field investigation. The investigation provided evidence of (a) proximal current leakage in herbaceous root systems, extending recent laboratory results and previous indirect field studies. (b) Major role of the plant stem, which has been a substantial concern raised in numerous studies. (c) Minor contribution from the soil, addressing the doubts on the comparability of results obtained in different soil conditions. All together, these evidences lead to indirect correlations between impedance signals and root traits. The explored solution is expected to support the adoption of the impedance spectroscopy, in line with the diffusion of multichannel impedance meters and growing interest in root physiology and phenotyping.
Simulation of Heat Flow Curves of NC‐Based Propellants – Part 1: Determination of Reaction Enthalpies and Other Characteristics of the Reactions of NC and Stabilizer DPA Using Quantum Mechanical Methods
Authors: Itkis Daniel G. , Bohn Manfred A. 
Published: July 2021

AbstractThe heat flow curves of nitrocellulose (NC)‐based propellants are now an important assessment quantity for their quality and safety in storage and service. The measurable heat flow is the summarized effect of the rates of all the reaction heats of the reactions going on in the material. To get a detailed assessment instead the only global one requires knowing the heat flow parts caused by NC and by stabilizer reactions. For this, in turn, one needs to find the reaction enthalpies of the essential NC decomposition reactions and the stabilizer reactions at the temperature of the measurement of the heat flow. These data are not available in the literature. To get meaningful data it was necessary to use quantum mechanical calculations, here so‐called DFT (density functional theory) methods, to screen the possible reactions by transition states and the energetic situation between educts and products. For the calculation of the reaction enthalpies and the transition states, the reactants were embedded in a polarizable continuum, which simulates the NC environment for the reactants in NC and for the stabilizer reactions. In addition, to calculate bond dissociation enthalpies of NC and of nitroglycerine a type of shell model was used called ONIOM (‘Our own N‐layered Integrated molecular Orbital and molecular Mechanics’ model). The results from the determinations of reaction enthalpies are used in the second part of the publication.
Study on a Method to Determine the Transverse Impact Strength of Propellants Based on Impact Absorbing Energy
Authors: Liu Ji‐Hua , He Chang‐Hui , Zhang Rui‐Hua , Zhao Hong‐Li , Wang Qiong‐Lin 
Published: July 2021

AbstractIn this paper, a measurement method of the transverse impact strength of propellant based on the initial fracture impact absorbing energy in the drop weight impact test is proposed. According to the relationship between load and time, displacement was deduced. The correctness and reliability of the displacement were confirmed by comparing it with the displacement by the digital image correlation method (DIC). Combined with a high‐speed camera, the impact process image was collected, and the initial fracture point was determined by the load‐displacement curve. Then the impact absorbing energy corresponding to the initial fracture point was obtained by integrating the displacement with a load. The transverse impact strength of the propellant can be acquired based on the initial cross‐sectional area of the sample. By comparison, it is found that the coefficient of variation and dispersion degree of the measurement results by the proposed method at low and room temperature are significantly less than those by the traditional pendulum test. That is, the consistency and repeatability of the proposed method are better. The result proves the feasibility and reliability of the method based on the initial fracture impact absorbing energy to measure the transverse impact strength of propellants.
Cryptic association of B7‐2 molecules and its implication for clustering
Authors: Lankipalli Swetha , H S Mahadeva Swamy , Selvam Deepak , Samanta Dibyendu , Nair Deepak , Ramagopal Udupi A. 
Published: July 2021

AbstractT‐cell co‐stimulation through CD28/CTLA4:B7‐1/B7‐2 axis is one of the extensively studied pathways that resulted in the discovery of several FDA‐approved drugs for autoimmunity and cancer. However, many aspects of the signaling mechanism remain elusive, including oligomeric association and clustering of B7‐2 on the cell surface. Here, we describe the structure of the IgV domain of B7‐2 and its cryptic association into 1D arrays that appear to represent the pre‐signaling state of B7‐2 on the cell membrane. Super‐resolution microscopy experiments on heterologous cells expressing B7‐2 and B7‐1 suggest, B7‐2 form relatively elongated and larger clusters compared to B7‐1. The sequence and structural comparison of other B7 family members, B7‐1:CTLA4 and B7‐2:CTLA‐4 complex structures, support our view that the observed B7‐2 1D zipper array is physiologically important. This observed 1D zipper‐like array also provides an explanation for its clustering, and upright orientation on the cell surface, and avoidance of spurious signaling.
A data‐driven sensor fault‐tolerant control scheme based on subspace identification
Authors: Salim Mina , Ahmed Saeed , Khosrowjerdi Mohammad Javad 
Published: July 2021

AbstractWe study the sensor fault estimation and accommodation problems in a data‐driven setting, leading to a data‐driven sensor fault‐tolerant control scheme. First, we formulate the fault estimation problem as a finite‐horizon minimax ‐optimization problem in a data‐driven setup, whose solution yields the fault estimate. The estimated fault is then used for output compensation. This compensated output and the experimental input are used to achieve certain control objectives in a data‐driven setting. Next, the data‐driven fault estimation and control problems are solved using a subspace predictor‐based approach. Finally, the proposed algorithm is applied to the steering subsystem of the remotely operated underwater vehicle.
Multistage Adaptive Nanoparticle Overcomes Biological Barriers for Effective Chemotherapy
Authors: Wang Ying , Zhang Zhanzhan , Zheng Chunxiong , Zhao Xinzhi , Zheng Yadan , Liu Qi , Liu Yang , Shi Linqi 
Published: July 2021

AbstractDrug delivery systems (DDS) are extensively studied to improve the solubility, stability, pharmacokinetic, and biodistribution of chemotherapeutics. However, the drug delivery efficiency of traditional DDS is often limited by the complicated biological barriers in vivo. Herein, a multistage adaptive nanoparticle (MAN) that simultaneously overcomes multiple biological barriers to achieve tumor‐targeted drug delivery with high efficiency is presented. MAN has a core–shell structure, in which both the core and the shell are made of responsive polymers. This structure allows MAN to present different surface properties to adapt to its surrounding biological microenvironment, thereby achieving enhanced stability in blood circulation, improved tumor accumulation and cellular internalization in tumor tissues, and effective release of drug in cells. With these unique characteristics, the MAN loaded with docetaxel achieves effective tumor suppression with reduced systemic toxicity. Furthermore, MAN can load almost any hydrophobic drugs, providing a general strategy for the tumor‐targeted delivery of hydrophobic drugs to overcome the multiple biological barriers and improve the efficacy of chemotherapy.
Molecular Coupling and Self‐Assembly Strategy toward WSe2/Carbon Micro–Nano Hierarchical Structure for Elevated Sodium‐Ion Storage
Authors: Zhang Ge , Ou Xuewu , Yang Jinghai , Tang Yongbing 
Published: July 2021

AbstractSodium (Na) ion‐based dual‐ion batteries (Na‐DIBs) have attracted great attention, owing to their benefits of low cost, high working voltage, and environmental friendliness. However, the limited capacity and low tap density of currently reported anode materials restrict the further improvement of Na‐DIBs. Herein, a micro–nano structure with vertically aligned WSe2 nanoflakes anchored tightly on a micron‐sized carbon sphere (WSe2/CS) is successfully constructed via combining the molecular coupling and self‐assembly strategy. Within this hierarchical structure, the WSe2 nanoflakes can shorten the diffusion path for Na+ ions and alleviate structural deformation during the charge/discharge process; meanwhile, the micron‐sized carbon core provides conductive support and helps improve the total tap density of the anode electrode. As a result, this micron‐sized WSe2/CS displays a high specific capacity of ≈252.8 mAh g−1 and good cycling performance with ≈92% capacity retention after 1200 cycles. Moreover, by pairing this WSe2/CS anode with environmental friendly graphite as cathode, a proof‐of‐concept Na‐DIB shows 85.6% capacity retention after 1000 cycles, which is among the best performances of previously reported Na‐DIBs.
Transverse abdominal plane block in a llama undergoing midline coeliotomy
Authors: Thomson Robyn , Deutsch Julia 
Published: July 2021

AbstractA 3‐year‐old llama was presented for management of bilateral ureter obstruction. A general anaesthetic was performed to allow a midline coeliotomy to be undertaken. Due to current legislation, the provision of adequate analgesia can be challenging. The transverse abdominis plane (TAP) block is a locoregional technique that can be used to provide analgesia of the ventral abdominal wall in numerous species. The TAP block was performed in this case to provide intraoperative analgesia using mepivacaine. This is the first time this technique has been described in the llama. Based on intraoperative monitoring, the TAP block appears to provide analgesia intra‐operatively. Due to the degree of damage to the ureters, the llama was euthanised under general anaesthesia, so an assessment of postoperative analgesia provided by the block could not be assessed.
Rethinking the role of law in adapting to climate change
Authors: McDonald Jan , McCormack Phillipa C. 
Published: July 2021

AbstractThe article evaluates the role of law in adaptation over the past decade. We track the emergence of international adaptation law within the climate and non‐climate regime, alongside increasingly dire extreme events and strident scientific consensus. Examining the growth in national and subnational laws for adaptation, we reflect on the role of framework legislation and legal mechanisms used in sectoral laws. Based on progress over the past decade, we outline how the role of law can be enhanced and accelerated in the decade ahead. We identify important trends in adaptation law and consider the potential for these innovations to drive future adaptation: the sheer growth in priority and volume of laws directed towards adaptation; the intersection of adaptation with other policy domains, especially disaster risk reduction; the need for improved architecture for funding adaptation; and the important role of strategic litigation. Largely absent from the past decade of adaptation law reform is evaluation of effectiveness, or examples of systemic reform that addresses underlying causes of vulnerability. With slow progress in implementing transformational adaptation law reform, we identify five design principles for adaptation laws. The design of laws must (1) be responsive to change; (2) address equity dimensions of climate change; (3) implement innovative solutions; (4) maximize co‐benefits; and (5) establish processes for managing trade‐offs.This article is categorized under:Vulnerability and Adaptation to Climate Change > Institutions for Adaptation
A method to estimate the probability of strong winds occurrence using weather radar data
Authors: Chiniforoush Navid , Latif Shabgahi Gholamreza , Azadi Majid 
Published: July 2021

AbstractWeather radars are capable of detecting and displaying storm‐related turbulence as well as precipitation rate with fine spatial resolution and reliable quality. Especially, weather radars can enable the detection of atmospheric conditions in the vicinity of cities and thereby help to notify the strong winds. This article investigates the application of weather radar measurements for predicting strong wind and presents a new method for very short‐term storm prediction. In the proposed method, hidden Markov model (HMM) is used to classify atmospheric conditions to “potentially stormy” and “non‐stormy” states using the available radar data, and semi‐Markov theory is used to estimate the probability of storm occurrence with time. In fact, the probability of transition between “potentially stormy,” “non‐stormy,” and “stormy” states is modeled by a semi‐Markov model, to find the unconditional probability of storm occurrence with time. The model is implemented with the use of the data of Tehran C‐band weather radar and anemometer of Tehran international airport. Verification results show that the precision (forecast accuracy) is around 0.19 and the recall is around 0.67 in the presented classification method.
Investigation ofPM10prediction utilizing data mining techniques: Analyze by topic
Authors: Srijiranon Krittakom , Eiamkanitchat Narissara , Ramingwong Sakgasit , Cosh Kenneth , Ramingwong Lachana 
Published: July 2021

AbstractCoarse particulate matter (PM10), the inhalable particles with an aerodynamic diameter smaller than 10 micrometers are one of the major air pollutions that affect human health. Over the previous decade, a number of researchers applied various data mining techniques to create a temporal prediction model. This study reviews and discusses 100 research articles in computer science and environmental science coming from the Scopus database. The three processes of data mining techniques, including data preparation, model creation, and model evaluation for prediction PM10are highlighted. A summary of the overall process directions of data mining as well as their output are revealed. Additionally, recommendations for future research are identified.This article is categorized under:Application Areas > Science and TechnologyTechnologies > Machine LearningTechnologies > Prediction
Zahnmedizinische Beschwerdebilder mit psychosozialem Hintergrund
Authors: Wolowski Anne , Schneider Hans-Joachim , Eger Thomas 
Published: July 2021

ZusammenfassungObwohl Mund und Zähne lebenslang eine zentrale Bedeutung für die Entwicklung und das Wohlbefinden eines Menschen haben, finden psychosoziale Aspekte von Krankheit und Gesundheit nur zögerlich Eingang in zahnmedizinische Erklärungsmodelle. Als interventionsbedürftige Störung wird einzig die Zahnbehandlungsangst mit Krankheitswert im Sinne einer spezifischen Phobie allgemein anerkannt. Diese beschreibt die intensive Gefühlsreaktion auf Elemente der zahnärztlichen Behandlungssituation, die für den Betroffenen Leiden verursacht und die angesichts der tatsächlichen Gefahren in der Situation übertrieben erscheint. Ansonsten besteht jedoch nach wie vor die Tendenz, Beschwerden im zahnmedizinischen Kontext eher somatisch zu erklären. Das wirkt sich auf die Erwartungshaltung Betroffener wie auch auf die interdisziplinäre Zusammenarbeit aus. Zur Verbesserung der interdisziplinären Unterstützung und des gegenseitigen Verstehens stellt der folgende Beitrag neben der Zahnbehandlungsangst und deren Folgen für die Mundgesundheit weitere Beschwerde- und Krankheitsbilder vor. Bei kraniomandibulärer Dysfunktion, Bruxismus, okklusaler Dysästhesie sowie somatoformer Prothesenunverträglichkeit können psychosoziale Aspekte in Entstehung, Verlauf und Bewältigung ebenfalls eine bedeutende Rolle spielen.
Development of elastic–plastic model of additively produced titanium for personalised endoprosthetics
Authors: Borovkov Alexey , Maslov Leonid , Tarasenko Fedor , Zhmaylo Mikhail , Maslova Irina , Solovev Dmitry 
Published: July 2021

AbstractThis study presents a model for Ti6Al4V alloy produced by applying electron beam melting as continuum media with orthotropic elastic and plastic properties and its application in total hip replacement (THR). The model exhibits three Young’s moduli, three shear moduli, and three Poisson’s ratios as elastic properties and six coefficients describing the Hill yield criterion. Several uniaxial tension and torsion experiments and subsequent data processing were performed to evaluate the properties and coefficients. The typical values obtained for Young’s moduli, shear moduli, and Poisson’s ratio were 121–124 MPa, 37–42 MPa, and 0.25–0.26, respectively. A comparison of the experimental tension and torsion curves with those obtained by a finite element analysis revealed a good correlation with a maximum error of 9.5%. The finite element simulation of a personalised pelvic implant for THR manufactured from the obtained material proved the mechanical capability of the implant to successfully withstand the applied loads.