bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbaikan Proses Produksi dan Peningkatan Pemasaran pada UKM Putri Timus Di Karanganyar
Authors: Giyanti Ida , Suparti Erni , Sunardi Sunardi , Sugiarti Sugiarti 
Published: May 2021

Abstract: Timus is one of the famous traditional foods in the Central Java region. Putri Timus is one of the Small Medium Enterprise (SME) in Karanganyar district producing purple Timus. Timus from Putri Timus have one special feature, in which in the inside of the Timus contains Bligo (Benincasa hispida) fruit with various benefits. Although Putri Timus has product differentiation, product by Putri Timus is not well known to the public. The production process was carried out on a home scale and has not fully implemented production standards based on the criteria for Good Food Manufacturing Practices for Home Industry (CPPB-IRTP). This community service program aims to help Putri Timus to implement hygiene requirements in food production based on CPPB-IRTP criteria and increase its marketing capacity. The method used to solve the problems were training of Good Food Manufacturing Practice, improvement of production place, facilitation of production cloths and promotional media. The results obtained after community service activities related to the production aspect were increasing knowledge regarding good food production process and improvement of production place. Regarding the marketing aspect, several promotional media have been installed. In addition, there was also an increasing of sales and profit. Keywords: traditional food; small medium enterprise; production; marketing Abstrak: Timus adalah salah satu makanan tradisional yang terkenal di Jawa Tengah. Putri Timus adalah salah satu Usaha Kecil Menengah di kabupaten Karanganyar yang memproduksi timus ungu. Produk dari Putri Timus memiliki satu keistimewaan yakni bagian dalam timus berisi buah Bligo (Benincasa hispida) dengan beragam manfaat. Meskipun produk memiliki diferensiasi, timus isi Bligo hasil produksi Putri Timus belum cukup dikenal masyarakat. Proses produksi dilakukan dalam skala rumahan dimana Putri Timus belum sepenuhnya menerapkan standar produksi berdasarkan kriteria Cara Produksi Pangan yang Baik – Industri Rumah Tangga Pangan (CPPB-IRTP). Program pengabdian masyarakat ini bertujuan membantu Putri Timus untuk dapat menerapkan syarat higiene dalam produksi pangan berdasarkan kriteria CPPB-IRTP serta meningkatkan kapasitas pemasaran. Metode yang digunakan untuk mengatasi permasalahan mitra ialah melalui penyuluhan tentang CPPB-IRTP, pembenahan tempat produksi, fasilitasi pakaian produksi dan media promosi. Hasil yang diperoleh setelah kegiatan pengabdian terkait aspek produksi ialah adanya peningkatan pengetahuan karyawan tentang CPPB-IRTP dan perbaikan tempat produksi yang lebih bersih dan layak. Terkait aspek pemasaran, beberapa media promosi telah dibuat dan dipasang. Selain itu juga terdapat peningkatan jumlah penjualan dan laba dari hasil penjualan timus.Kata kunci: makanan tradisional; produksi; pemasaran; usaha kecil dan menengah.
Capacidade de autodepuração em ambiente lótico a partir do modelo matemático de Streeter-Phelps no nordeste paraense
Authors: Pereira Junior Antonio , Miranda Ayla Fernandes Muniz , Barros Estefani Danielle de Araujo , Sardinha Aline Souza 
Published: May 2021

O município de Capanema - PA, se desenvolveu às margens do rio Ouricuri. Em face disso, é importante o conhecimento da capacidade de autodepuração desse recurso hídrico. O objetivo desta pesquisa foi analisar quantiqualitativamente, a simulação da capacidade de autodepuração desse ambiente lótico, e propor duas medidas mitigatórias para a redução dos impactos gerados no corpo hídrico e melhorias na qualidade da água. O método foi dedutivo, abrangência quantiqualitativa e natureza aplicada. Os dados obtidos e analisados, para os três pontos, P1, P2 e P3, no período chuvoso: para o Rio Ouricuri foram, OD: = 0,26 mg/L; DBO5: = 10 mg/L; vazão: = 1,80 m³/s; temperatura: = 26 ºC, para a anilha de efluentes: OD: = 0,16 mg/L, DBO5: = 300 mg/L; vazão: 0,88 m³/s; temperatura: = 26 ºC. No período seco, para o Rio Ouricuri: OD: = 0,16 mg/L; DBO5: = 10 mg/L; vazão: = 0,93 mg/L; e temperatura: = 25 ºC; para a anilha de efluentes: OD: = 0,43 mg/L, DBO5: = 300 mg/L, vazão: = 0,88 m³/s e temperatura: = 27 °C. Comparam-se os valores de OD, e DBO com a Resolução CONAMA 357/05, e verificou-se que estão em não conformidade, logo, o rio é considerado poluído tanto para potabilidade quanto para balneabilidade. Portanto, é necessário que os órgãos responsáveis no município utilizem dos dados aqui contidos para elaboração de medidas mitigatórias para a recuperação do rio.
Kebijakan Dividen Pada Perusahaan Sektor Industri Barang Konsumsi di Indonesia: Kebijakan Utang, Profitabilitas, Likuiditas
Authors: Firmansyah Amrie , Asikin Nurlatifah , Gultom Samtri Dortua 
Published: May 2021

Penelitian ini bertujuan untuk menginvestigasi pengaruh kebijakan utang, profitabilitas, dan likuiditas terhadap kebijakan dividen. Penelitian ini menggunakan data sekunder yang bersumber dari laporan keuangan tahunan perusahaan sektor Barang Konsumsi yang tercatat di Bursa Efek Indonesia (BEI) periode 2017-2019. Sumber data berupa laporan keuangan diperoleh dari website resmi Bursa Efek Indonesia dengan laman http://www.idx.co.id. Berdasarkan purposive sampling telah dilakukan, total sampel yang digunakan dalam penelitian ini berjumlah 63 observasi. Pengujian hipotesis menggunakan regresi data panel. Hasil pengujian menunjukkan bahwa kebijakan utang, profitabilitas, dan likuiditas tidak berpengaruh terhadap kebijakan dividen. Oleh karena itu, informasi dari ketiga variabel tersebut tidak dapat digunakan sebagai sinyal dalam memprediksi kebijakan dividen perusahaan. Penelitian ini mengindikasikan bahwa informasi atas tingkat utang, laba rugi, dan jumlah kas dalam laporan keuangan tidak digunakan oleh investor dalam menilai kebijakan dividen perusahaan.
Preparation and Characterization of Polymer based Electrolytes for Dye-sensitized Solar Cell Application
Authors: I Chowdhury Faisal , Hossain M. Zabed , Buraidah M. H. , A. K. Arof  , Jahidul Islam  , Rahman M. Rezaur , Uddin Jamal 
Published: May 2021

A gel-type polymer electrolyte (GPE) composite based on polyacrylonitrile (PAN) conducting polymer plasticized with ethylene carbonate (EC) and propylene carbonate (PC) doped by different compositions of tetrapentylammonium iodide (TPeAI) salt has been prepared and investigated. Electrochemical impedance spectroscopy (EIS) and linear sweep voltammetry (LSV) techniques have been used to characterize the prepared GPEs. From the EIS study, it has been observed that 30 wt % TPeAIcontaining GPE has the lowest bulk impedance, Rb (32 ohm) and highest room-temperature ionic conductivity (2.4910-3 S cm-1). The conductivity vs temperature diagram in the range of studied temperature studied follows the Arrhenius rule. The values of activation energies, (Ea) are observed to decrease with the increase of the percentage of TPeAI percentage with the lowest values (8.50105 J/mol) for 30% TPeAI containing GPE. From LSV graphs for the GPE systems, various parameters such as the limiting current density (Jlim), the apparent diffusion coefficient of triiodide ion () and exchange current density (J0) have been estimated. The most conducting GPE material shows the highest values of Jlim (3.95 mA.cm-2), (7.86×10-8cm2 s-1) and J0 (0.46 mA.cm-2). The GPEs will be suitable for application in Dye-sensitized Solar Cell (DSSC).
Low-Level Stimulation and Ethanol Ablation of the Vein of Marshall Prevent the Vagal-Mediated AF
Authors: Liu Fei , Sun Wei , Li Yan , Sun Yuanjun , Yu Xiaohong , Yin Xiaomeng , Xia Yunlong 
Published: May 2021

Background: The mechanisms for the vein of Marshall (VOM) mediated atrial fibrillation (AF) are not completely understood. We sought to evaluate the contribution of the intrinsic cardiac autonomic nervous system in VOM mediated AF.Method: Seven mongrel dogs were administered propranolol and continuously exposed to left superior ganglionated plexi (LSGP) stimulation, LSGP + low-level VOM stimulation, LSGP + atropine administration, LSGP + VOM filling with ethanol separately. The effective refractory period (ERP) and window of vulnerability (WOV) at the left superior pulmonary vein (LSPV), left inferior pulmonary vein (LIPV) and left atrial appendage (LAA) were measured.Result: LSGP stimulation significantly shortens the ERP and prolonged the ERP dispersion and WOV in LSPV, LIPV, and LAA. Interestingly, low-level VOM stimulation, atropine administration, or VOM filling with ethanol were able to attenuate the effects of LSGP in all sites.Conclusion: VOM as an inter-communication pathway of ganglionated plexis plays an important role in the development of vagal-related AF.
Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A–Producing γδ T Cells
Authors: Zhang Song , Zhang Jia , Yu Juanjuan , Chen Xiaolu , Zhang Fangyuan , Wei Wei , Zhang Lingyun , Chen Wenmao , Lin Nengxing , Wu Yan 
Published: May 2021

Hyperforin is a major active constituent of Hypericum perforatum L. extract, which is widely used for the treatment of depressive disorders. Recent studies have reported that hyperforin reduced inflammation in stroke and suppressed proliferation and differentiation in keratinocytes. Psoriasis is a chronic immune-mediated inflammatory skin disease in which the IL-23/IL-17 axis plays an important role. To investigate the underlying inflammatory mechanisms and response of hyperforin in psoriasis, we use imiquimod (IMQ)-induced mice model, in vitro cultured murine splenic γδ T cells, and HaCaT cells in this study. Data showed that hyperforin reduced epidermal thickness and decreased IMQ-induced pathological scores of cutaneous skin lesions in mice. Meanwhile we proved that hyperforin suppressed infiltration of CD3+ T cells and downregulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion. Hyperforin significantly inhibited imiquimod-induced splenomegaly, reduced serum levels of TNF-α and IL-6, and IL-17A in splenocytes and draining lymph nodes. Our study also suggested that hyperforin lessened the infiltration of γδ T cell and CCR6+ γδ T cells in spleen and lymph nodes. Hyperforin also suppressed the typical psoriasis-like inflammatory responses and the infiltration of IL-17A+ cells in dermal γδ T cells of IMQ treated Tcrd−/− mice transferred with γδ T cells. In vitro studies, hyperforin reduced the expression and secretion of IL-17A in γδ T cells, and suppressed the activation of MAPK/STAT3 pathways in human keratinocyte HaCaT cells and γδ T cells. In conclusion, hyperforin alleviates IMQ-induced inflammation in psoriasis through suppressing the immune responses exerted by IL-17 A-producing γδ T cells and related cytokines by modulating MAPK/STAT3 pathways. Our study provided a novel therapeutic tragedy for psoriasis by which hyperforin attenuates psoriasis-related inflammatory responses.
Sarcopenia Is Associated With Increased Risks of Rotator Cuff Tendon Diseases Among Community-Dwelling Elders: A Cross-Sectional Quantitative Ultrasound Study
Authors: Han Der-Sheng , Wu Wei-Ting , Hsu Po-Cheng , Chang Hsiang-Chi , Huang Kuo-Chin , Chang Ke-Vin 
Published: May 2021

Backgrounds: Recently, the association between sarcopenia and various musculoskeletal disorders, such as lumbar spine stenosis and fibromyalgia, has been highlighted. However, the relationship between sarcopenia and rotator cuff tendon diseases has rarely been investigated. This study aimed to evaluate whether sarcopenia was associated with shoulder pain and to determine whether rotator cuff tendons differed in echotexture between the sarcopenic and non-sarcopenic populations.Methods: The thickness and echogenicity ratio of the tendon vs. the overlying muscle (ERTM) or subcutaneous tissue (ERTT) were measured using high-resolution ultrasonography in 56 sarcopenic patients and 56 sex- and age- matched controls. The association between ultrasound measurements of the rotator cuff tendon complex and sarcopenia was investigated using the generalized estimating equation (GEE).Results: The sarcopenic group had an increased prevalence of shoulder pain. Based on the GEE analysis, sarcopenia was significantly associated with an increase in supraspinatus tendon thickness (β coefficient = 0.447, p &lt; 0.001) and a decrease in the ERTM for the biceps long head and rotator cuff tendons. A negative trend of association was observed between sarcopenia and ERTT in the supraspinatus tendons (β coefficient = −0.097, p = 0.070). Nevertheless, sarcopenia was not associated with an increased risk of rotator cuff tendon tears.Conclusions: Patients with sarcopenia have a higher risk of shoulder pain. A consistent tendinopathic change develops in the supraspinatus tendons in sarcopenic patients. However, sarcopenia is less likely to be associated with serious rotator cuff pathology, such as tendon tears. Prospective cohort studies are warranted to explore the causal relationship between sarcopenia and shoulder disorders.
Measuring Core Body Temperature Using a Non-invasive, Disposable Double-Sensor During Targeted Temperature Management in Post-cardiac Arrest Patients
Authors: Janke David , Kagelmann Niklas , Storm Christian , Maggioni Martina A. , Kienast Camilla , Gunga Hanns-Christian , Opatz Oliver 
Published: May 2021

Background: Precisely measuring the core body temperature during targeted temperature management after return of spontaneous circulation is mandatory, as deviations from the recommended temperature might result in side effects such as electrolyte imbalances or infections. However, previous methods are invasive and lack easy handling. A disposable, non-invasive temperature sensor using the heat flux approach (Double Sensor), was tested against the standard method: an esophagus thermometer.Methods: The sensor was placed on the forehead of adult patients (n = 25, M/F, median age 61 years) with return of spontaneous circulation after cardiac arrest undergoing targeted temperature management. The recorded temperatures were compared to the established measurement method of an esophageal thermometer. A paired t-test was performed to examine differences between methods. A Bland-Altman-Plot and the intraclass correlation coefficient were used to assess agreement and reliability. To rule out possible influence on measurements, the patients' medication was recorded as well.Results: Over the span of 1 year and 3 months, data from 25 patients were recorded. The t-test showed no significant difference between the two measuring methods (t = 1.47, p = 0.14, n = 1,319). Bland-Altman results showed a mean bias of 0.02°C (95% confidence interval 0.00–0.04) and 95% limits of agreement of −1.023°C and 1.066°C. The intraclass correlation coefficient was 0.94. No skin irritation or allergic reaction was observed where the sensor was placed. In six patients the bias differed noticeably from the rest of the participants, but no sex-based or ethnicity-based differences could be identified. Influences on the measurements of the Double Sensor by drugs administered could also be ruled out.Conclusions: This study could demonstrate that measuring the core body temperature with the non-invasive, disposable sensor shows excellent reliability during targeted temperature management after survived cardiac arrest. Nonetheless, clinical research concerning the implementation of the sensor in other fields of application should be supported, as well as verifying our results by a larger patient cohort to possibly improve the limits of agreement.
A Rare Cause of Pulmonary Nodules Diagnosed as Angiosarcoma Was Misdiagnosed as Vasculitis and Wegener’s Granuloma in an Elderly Man: A Case Report
Authors: Wang Peixia , Xu Liqian , Yang Yunmei 
Published: May 2021

BackgroundAngiosarcoma is a rare, highly malignant tumor prone to recurrence and metastasis. Angiosarcoma is insidious in the initial stage, and its clinical manifestation lacks specificity. The diagnosis is based on histopathology and immunohistochemistry findings.Case presentationA 73-year-old man was hospitalized following complaints of persistent cough 6 months and hemoptysis for 2 months. Anti-infective treatment was ineffective. A CT-guided percutaneous core needle biopsy of pulmonary lesions revealed organized pneumonia, and the removed skin of purpuric rash area on the left calf revealed vasculitis. Chest CT was used during the patient follow-up. Hormonal therapy combined with immunoglobulins did not lead to improvement, and there was rapid progression of the lung lesions. Subsequently, the patient underwent a surgery, the diseased tissue was separated and removed completely beside the left submandibular gland under local anaesthesia. The immunohistochemical staining indicated CD31 (+) and CD34 (+) confirming a diagnosis of metastatic angiosarcoma. The expression of PD-L1 was 70%, therefore, anlotinib and pembrolizumab treatments were initiated. The patient eventually died.ConclusionAngiosarcoma is a malignant tumor in the clinic that lacks typical and specific signs and symptoms. The diagnosis depends on immunohistochemistry, which requires repeated biopsies of multiple sites in highly suspected cases.
Development and Prospective Validation of an Ultrasound Prediction Model for the Differential Diagnosis of Benign and Malignant Subpleural Pulmonary Lesions: A Large Ambispective Cohort Study
Authors: Bi Ke , Xia De-meng , Fan Lin , Ye Xiao-fei , Zhang Yi , Shen Meng-jun , Chen Hong-wei , Cong Yang , Zhu Hui-ming , Tang Chun-hong , Yuan Jing , Wang Yin 
Published: May 2021

ObjectiveTo develop and prospective validate an ultrasound (US) prediction model to differentiate between benign and malignant subpleural pulmonary lesions (SPLs).MethodsThis study was conducted retrospectively from July 2017 to December 2018 (development cohort [DC], n = 592) and prospectively from January to April 2019 (validation cohort [VC], n = 220). A total of 18 parameters of B-mode US and contrast-enhanced US (CEUS) were acquired. Based on the DC, a model was developed using binary logistic regression. Then its discrimination and calibration were verified internally in the DC and externally in the VC, and its diagnostic performance was compared with those of the existing US diagnostic criteria in the two cohorts. The reference criteria were from the comprehensive diagnosis of clinical-radiological-pathological made by two senior respiratory physicians.ResultsThe model was eventually constructed with 6 parameters: the angle between lesion border and thoracic wall, basic intensity, lung-lesion arrival time difference, ratio of arrival time difference, vascular sign, and non-enhancing region type. In both internal and external validation, the model provided excellent discrimination of benign and malignant SPLs (C-statistic: 0.974 and 0.980 respectively), which is higher than that of “lesion-lung AT difference ≥ 2.5 s” (C-statistic: 0.842 and 0.777 respectively, P &lt;0.001) and “AT ≥ 10 s” (C-statistic: 0.688 and 0.641 respectively, P &lt;0.001) and the calibration curves of the model showed good agreement between actual and predictive malignancy probabilities. As for the diagnosis performance, the sensitivity and specificity of the model [sensitivity: 94.82% (DC) and 92.86% (VC); specificity: 92.42% (DC) and 92.59% (VC)] were higher than those of “lesion-lung AT difference ≥ 2.5 s” [sensitivity: 88.11% (DC) and 80.36% (VC); specificity: 80.30% (DC) and 75.00% (VC)] and “AT ≥ 10 s” [sensitivity: 64.94% (DC) and 61.61% (VC); specificity: 72.73% (DC) and 66.67% (VC)].ConclusionThe prediction model integrating multiple parameters of B-mode US and CEUS can accurately predict the malignancy probability, so as to effectively differentiate between benign and malignant SPLs, and has better diagnostic performance than the existing US diagnostic criteria.Clinical Trial Registrationwww.chictr.org.cn, identifier ChiCTR1800019828.
Intermittently Scanned and Continuous Glucose Monitor Systems: A Systematic Review on Psychological Outcomes in Pediatric Patients
Authors: Franceschi Roberto , Micheli Francesca , Mozzillo Enza , Cauvin Vittoria , Liguori Alice , Soffiati Massimo , Giani Elisa 
Published: May 2021

Aim: To explore the impact of real-time continuous glucose monitoring (rtCGMs) or intermittently scanned/viewed CGM (isCGM) on psychological outcomes in children and caregivers, and to grade the level of evidence.Method: Systematic review of the literature from PubMed, Embase, Cochrane Library, Web of Science, CINAHL, Nursing reference center, Up to date, Google Scholar, and PsycINFO databases. The studies selected used validated questionnaires for investigating the psychological outcomes. We applied GRADE (Grading of Recommendations Assessment, Development and Evaluation) to rank the quality of a body of evidence.Results: A total of 192 studies were identified in the initial search and after the process of evaluation 25 studies were selected as appropriate to be included in this systematic review. We found in moderate quality studies that isCGM in adolescents can improve diabetes related distress, family conflicts, fear of hypoglycemia, and quality of life, while depression, anxiety, and quality of sleep have not yet been evaluated by validated questionnaires. In moderate—high quality studies, rtCGM technology does not impact on diabetes burden, diabetes specific family conflict, and depressive symptoms. The effect on fear of hypoglycemia, sleep quality, and anxiety is still debated and RCT studies powered to find significant results in psychological outcomes are lacking. RtCGM increases satisfaction and quality of life in parents and patients wearing rtCGM.Conclusion: these data present an interesting point to consider when families are deciding whether or not to start CGM use, choosing between rtCGM to reach a tighter metabolic control, or isCGM which allows greater benefits on psychological outcomes.
The Shipibo Ceremonial Use of Ayahuasca to Promote Well-Being: An Observational Study
Authors: Gonzalez Debora , Cantillo Jordi , Perez Irene , Carvalho Maria , Aronovich Adam , Farre Magi , Feilding Amanda , Obiols Jordi E. , Bouso José Carlos 
Published: May 2021

Promoting well-being is one of the main goals to improve health in the world. We examined the well-being and quality of life over the course of one year in a sample that participated in an Indigenous Shipibo healing program where traditional healers work in a series of ayahuasca ceremonies. We also explored the role of decentering as a mediator of psychological well-being. Participants who attended the program responded to an online survey that included a Psychological Well-Being Scale; Oxford Happiness Questionnaire; The World Health Organization Quality of Life Spirituality, Religiousness, and Personal Beliefs scale; the WHO Quality of Life-BREF scale; and Decentering scale. Baseline (T0) and postassessment (T1) were completed by 200 individuals. Of these, 101 completed the follow-up assessment at three months (T2), 91 at 6 months (T3), and 94 at 12 months follow-up (T4) after leaving the center. ANOVA test was performed in a representative subsample to control the passing of time two months before attending the program (T-1). Pearson’s test was performed to examine the relationship between psychological well-being and decentering during the period of T0 and T1. A significant increase was observed in all the scales at all time points (p≤ 0.01). The subgroup analysis performed in a representative subsample allowed us to infer that the significant differences in outcomes are due to the effect of their stay at the center and not the passing of time. We found a relationship between decentering and the improvement of psychological well-being (r= 0.57;p&lt; 0.01). Our results suggest that the Indigenous Shipibo healing work with ayahuasca has value to improve long-term well-being and quality of life for Westerners.