bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEUROMUSCULAR MECHANISMS AND EFFECTS OF CORE STABILIZATIONS ON TRUNK AND HIP MUSCLE ACTIVITY DURING LIFTING MOVEMENT
Authors: CHOI HYOUNGJOO , PARK CHANHEE , HWANG JONGSEOK , YOU JOSHUA SUNG H. 
Published: August 2021

While the presence of lumbopelvic-hip stabilization has been provided as an importance component of the intra-abdominal pressure and dynamic spinal stabilization prior to movement, no previous study has investigated the effects in nonsymptomatic adults. This study investigated neuromuscular mechanisms and effects by comparing the natural core stabilization (NCS), abdominal bracing stabilization (ABS), and coordinated core stabilization (CCS) techniques in nonsymptomatic adults during lifting movement. A convenience sample of 40 nonsymptomatic adults (mean [Formula: see text] standard deviation, [Formula: see text]; 27 males, 13 females) were randomized into the NCS, ABS, and CCS techniques during lifting movement. The clinical outcomes included the deep and local (transverse abdominis (TrA), internal oblique (IO), and gluteus maximus (Gmax)) and superficial and global muscle (thoracic erector spinae (TES), lumbar erector spinae (LES), and external oblique (EO)) activation and balance ratios (IO/LES and Gmax/LES) and onset time co-activation ratios (IO/LES and Gmax/LES). One-way repeated-measures analysis of variance (ANOVA) and Bonferroni correction revealed that the IO/LES and Gmax/LES balance and activation ratios were greater in CCS than in NCS and ABS. The onset time co-activation ratio was improved in CCS as compared with NCS and ABS, and ABS dropped equally inversely to NCS. Our results provide novel therapeutic evidence that CCS-based lifting movement is more balanced or coordinated in terms of neuromuscular control than the other techniques and may be used as an alternative exercise for core stabilization.
Research on Dewatering Ability of Municipal Sludge under the Treatment of Coupled Acid and Microwave
Authors: Zhang Xudong , Ye Peng , Wu Yajun , Guo Zhen , Huang Yuan , Zhang Xingtao , Sun Yuncong , Zhang Haiqiang 
Published: August 2021

Municipal sludge is a by-product of urban sewage treatment; it has high water content and contains many hydrophilic extracellular polymeric substances (EPS). It is difficult to achieve deep dewatering of sludge. Therefore, it is necessary to find an efficient method to treat sludge. In this study, an acid-microwave treatment method was proposed to improve the dewatering ability of sludge. A vacuum filtration test and particle size analysis test were used to explore the improvement effect of dehydration performance. After centrifugation, the concentrations of soluble proteins and polysaccharides in the supernatant were measured to explore the disintegration of acid-microwave treatment on EPS. Finally, the microstructure of sludge treated by acid-microwave was studied via the SEM test. The results showed that short-term microwave radiation was conducive to sludge dewatering. However, the sludge dewatering performance deteriorated significantly when the treatment time was too long. The optimal microwave treatment condition was 700 W for 180 s, and the SRF of sludge was the lowest, which was

10.11
×

10

12

m
/
kg

. After acid-microwave treatment, sludge particle size increased significantly. The concentration of protein and polysaccharide in supernatant increased with the increase of microwave treatment time. Acid-microwave treatment could significantly improve the release efficiency of the polysaccharide. Through the SEM test, it can be verified that the bulk floc structure of sludge is broken after microwave treatment, and acid-microwave treatment is beneficial to the aggregation of floc fragments to form large particles, which can provide larger pores for drainage.
AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4
Authors: Liu Jinquan , Yuan Bo , Cao Jin , Luo Hongjie , Gu Shuchen , Zhang Mengdi , Ding Ran , Zhang Long , Zhou Fangfang , Hung Mien-Chie , Xu Pinglong , Lin Xia , Jin Jianping , Feng Xin-Hua 
Published: August 2021

Abstract

Transforming growth factor β (TGFβ) is prometastatic in advanced cancers and its biological activities are mainly mediated by the Smad family of proteins. Smad4 is the central signal transducer and transcription factor in the TGFβ pathway, yet the underlying mechanisms that govern transcriptional activities of Smad4 are not fully understood. Here, we show that AMBRA1, a member of the DDB1 and CUL4-associated factor (DCAF) family of proteins, serves as the substrate receptor for Smad4 in the CUL4-RING (CRL4) ubiquitin ligase complex. The CRL4-AMBRA1 ubiquitin ligase mediates nonproteolytic polyubiquitylation of Smad4 to enhance its transcriptional functions. Consequently, AMBRA1 potentiated TGFβ signaling and critically promoted TGFβ-induced epithelial-to-mesenchymal transition, migration, and invasion of breast cancer cells. Mouse models of breast cancer demonstrated that AMBRA1 promotes metastasis. Collectively, these results show that CRL4-AMBRA1 facilitates TGFβ-driven metastasis by increasing Smad4 polyubiquitylation, suggesting AMBRA1 may serve as a new therapeutic target in metastatic breast cancer.

Significance:
This study identifies AMBRA1 as a novel regulator of TGFβ signaling and breast cancer metastasis, supporting further exploration of AMBRA1 as a target for cancer therapy.
John Locke político: a marca da tolerância, de Antônio Carlos dos Santos
Authors: Almeida Maria Cecília Pedreira de , Silva Saulo Henrique Souza 
Published: August 2021

Trata-se de resenha escrita pelos professores Maria Cecília Pedreira de Almeida e Saulo Henrique Souza Silva a respeito do livro John Locke Político: a marca da tolerância, escrito pelo professor Antônio Carlos dos Santos (Edições Loyola, 2021).
The Job Was Being Done: A Conversation About Dominika Macocha’s Video-sculptural Installation “50°31’29.7”N 22°46’39.1”E, 50°30’56.2”N 22°46’01.0”E, 50°30’41.0”N 22°45’49.5”E”
Authors: Janicka Elżbieta , Matyjaszek Konrad , Stańczyk Xawery , Stoll Katrin , Zawadzka Anna 
Published: August 2021

This article is a record of a discussion concerning Dominika Macocha’s video-sculptural installation 50°31’29.7”N 22°46’39.1”E, 50°30’56.2”N 22°46’01.0”E, 50°30’41.0”N 22°45’49.5”E. The work deals with the uses of discourse and landscapes in mechanisms of camouflaging the crimes perpetrated on Jews by Poles during the Holocaust. The author lays bare and deconstructs these mechanisms – above all the mechanisms of narrative fetishism of production of artificial landscape – drawing on examples from Biłgoraj county. In the course of the discussion, the work inspired a critical reassessment of the categories dominating the ways in which the Holocaust is currently described: (1) Martin Pollack’s category of contaminated landscapes, rooted in the ideology of two totalitarianisms; (2) the category of the witness / bystander, which conceals the observers’ participation in the scenario of the crime; and (3) the category of taboo, which is ambivalent considering the universal knowledge on the part of local communities about what happened to Jews from their localities. Reflection on the production of taboo leads the discussants to deliberate on the status of Jewish sources in the field of Holocaust studies. Collected since as early as the 1940s, and containing ample and detailed information about Polish crimes perpetrated on Jews, they are nevertheless not recognised as sources by Polish historians. The conversation is concluded by an attempt at recapitulating the present condition of Polish historiography in the light of the postulated new approach to sources.
Improving practice: Giving voice to the experiences of sexual health education teachers
Authors: Cummings Carol A , Fisher Christine M , Reilly-Chammat Rosemary 
Published: August 2021

Objective: To explore teachers’ beliefs, experiences and barriers influencing teaching related to sexual health education. Methods, Design and Setting: Descriptive, cross-sectional study design. Rhode Island certified health teachers ( n = 190) completed an online sexual health education survey. Teacher perceptions about the need and benefits of teaching this subject, coverage of essential topics, their experiences and the barriers they faced were gathered. Qualitative questions were analysed using open, axial and selective coding. Constant comparative approach was used to identify themes. Descriptive statistics were used to analyse quantitative items. Results: Findings indicated that 98% of teachers felt that sexual health education should be taught. Less than 50% agreed that coverage for topics identified in the national sexuality education standards for grades K-12 should begin at each grade level. Two common themes – prevention and access to accurate information – emerged as reasons for teaching the subject. Themes generated from teacher experiences revealed the use of a risk reduction approach to sexual health education. Healthy sexual development, gender identity, inclusive education and all components of a comprehensive approach were not identified. Perceived barriers to teaching included teacher comfort, time, parents’ likely responses and lack of training. Conclusion: Findings signal the need for ongoing professional development to broaden teachers’ understanding of comprehensive sex education and address the beliefs and barriers that hinder inclusive and comprehensive teaching approaches. Good quality training in which teachers reflect on their beliefs and develop proficiency in the use of effective pedagogies can strengthen educator capacity and self-efficacy.
Causal Nexus Between Crude, Gold, Dollar and Stock Markets in India: Empirical Explorations Before, During and After the Global Recession
Authors: Saji T. G. 
Published: August 2021

This research study empirically examines the price linkages among oil, dollar, gold and stock markets in India over period from 1999:1 to 2019:12. We employ cointegrated vector error correction model (VECM) and Granger causality test to study the long-run and short-run relationships between commodity and financial markets before, during and after the global financial crisis. Our analysis finds the dependency on price movements in asset markets is time-varying and countercyclical in India. Findings suggest the asymmetric structure of price correlations among asset markets across three temporal periods on either side of the crisis. Our study offers useful insights into the strategic asset allocations to investors in response to economic cycles, to help optimise potential portfolio returns and provide protection towards some downside risks. JEL Codes: C58, D53, F51
The Intersubjective Markets Hypothesis
Authors: Bocher Romain 
Published: August 2021

This study aims to introduce a new theoretical framework for capital markets understanding, reconciling findings from various disciplines such as anthropology, psychology, biology, statistics and physics. Assuming intersubjectivity to be the main driver of interactions between participants, the concept of market narrative is defined as subculture (or ideology) that influences the way investors react to both external events and endogenous dynamics. The new hypothesis is consistent with properties such as self-organisation, speculation, dependency, unboundedness, nonlinearity, dialogic and criticality. JEL: D40, D50, D53, D70, D80
Breastfeeding: Knowledge, Perception, And Intention to Practice Among Female Students of Tertiary Institutions in Ekiti, Southwest Nigeria
Authors: Ogundare Ezra , Babatola Adefunke , Omoyajowo Adefunke , Ajite Adebukola , Adeniyi Adewuyi , Fatunla Odunayo , Ojo Temitope , Agbesanwa Tosin , Olubosede Omolayo , Taiwo Adekunle , Oluyi Adedayo , Ajibola Ayotunde , Komolafe Akinwumi , Airemionkhale Alfred , Oluwayemi Isaac , Olatunya Oladele 
Published: August 2021

Introduction Breastfeeding is a public health practice that is critical for the survival of infants and young children. This study aimed at determining the knowledge, attitude, and future intention to breastfeed among female undergraduates in tertiary institutions in Ekiti State, Southwest Nigeria. Methodology: A prospective cross-sectional study was conducted among 1312 female students of the tertiary institutions in Ekiti State. By convenience sampling, female students were invited to participate in the study after giving verbal consent and those studying medical, nursing, and other courses allied to medicine were excluded. Internal consistency of the data obtained from this research instrument was determined using Cronbach’s coefficient Alpha with a reliability value of 0.82. Data analysis was conducted using SPSS version 25. Descriptive as well as inferential statistics were computed. Results were summarized as frequencies and percentages. The differences in knowledge, attitude, and intention to practice breastfeeding as well as other responses among the participants were compared among age groups, faculties and the sources of information using Chi-square test. Result Although 93% of the respondents agreed that breast milk is important for the development of the infant’s brain thereby demonstrating good knowledge; 51.6% of the respondents demonstrated poor perception to breastfeeding believing breastfeeding makes the breast to sag while only 34% of the respondents indicated their intention to breastfeed their future babies. Conclusion The intention to breastfeed among our study participants was poor. This study revealed the need to increase awareness about breastfeeding and its benefits among this huge population of future mothers.
The Effect of Prearrest Acid-Base Status on Response to Sodium Bicarbonate and Achievement of Return of Spontaneous Circulation
Authors: Mclean Heath , Wells Lindsey , Marler Jacob 
Published: August 2021

Background The efficacy of sodium bicarbonate (SB) administration during in-hospital cardiac arrest (IHCA) for treatment of acidosis is not well described. The available literature has only evaluated out-of-hospital arrest events in patients with suspected acidosis caused by prolonged arrest. Objective This study evaluated SB and its effects on return of spontaneous circulation (ROSC) in patients experiencing IHCA, based on presence of acidosis at baseline as determined by prearrest bicarbonate levels. Methods We conducted a retrospective cohort study of patients who all received intravenous SB during IHCA. Patients with prearrest bicarbonate levels >21 mmol/L (nonacidotic group) were compared with those with prearrest bicarbonate levels ≤21 mmol/L (acidotic group) for the primary outcome of ROSC. Results A total of 225 patients (102 acidotic, 123 nonacidotic) were evaluated. Asystole (37.3% vs 34.1%; P = 0.63) and pulseless electrical activity (30.4% vs 29.3%; P = 0.85) were the most common presenting rhythms. There were no differences in ROSC in the overall population (53.9% vs 48.8%; P = 0.44) or between those who had early (within 20 minutes) or delayed (after 20 minutes) ROSC. Secondary outcomes, including cardiopulmonary resuscitation duration, epinephrine administration, and total SB, were similar between groups. Conclusions and Relevance In this cohort study, administration of SB for IHCA in patients with prearrest acidosis was not associated with increased incidence of ROSC compared with those without prearrest acidosis. Our data suggest that there may be no benefit to the administration of SB in the setting of IHCA, regardless of prearrest acidotic status. Further investigation into the effect of SB for treatment of acidosis in IHCA is warranted.
First Reported Case of Anti-Ampa Receptor Encephalitis in a Vietnamese Adolescent
Authors: Trung Hieu Nguyen Le , Minh Duc Nguyen , Tra My Thieu-Thi , Hieu Anh Bui , Tan Lien Bang Mai , Minh Thong Pham 
Published: August 2021

Introduction: Autoimmune encephalitis refers to a group of diseases characterized by the presence of antibodies that directly attack receptors on the neuron surface and are associated with cognitive and behavioral disorders. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor autoimmune encephalitis is very rare and has been reported in only a few individual cases, with little clinical experience. Case report: We describe the clinical manifestation and disease course of the first diagnosed case of anti-AMPA receptor encephalitis at the Neurology Department of Children’s Hospital 2 in November 2020. A previously healthy 10-year-old presented with symptoms over 2 periods. During each period, the patient presented with multiple focal seizures, a cognitive-behavioral disorder, and amnesia. The brain magnetic resonance imaging (MRI) results were persistently normal. Electroencephalography (EEG) recorded many focal spikes and spike waves. Antibodies against N-methyl D-aspartate (NMDA) were not detected. Antibodies against AMPA receptors were detected in the serum and cerebrospinal fluid using an indirect fluorescent antibody test. This patient was treated with immunotherapy, including methylprednisolone and intravenous immunoglobulin (IVIG), and antiepileptic drugs, such as oxcarbazepine, topiramate, and levetiracetam. The seizures were controlled, but the cognitive-behavioral disorder was only partially resolved. Conclusion: This case report contributes to the clinical understanding of anti-AMPA receptor encephalitis disease manifestation, the response to the immunotherapy, and relapse.
Bilateral Nephroureterectomy Versus Unilateral Nephroureterectomy for Treating De Novo Upper Tract Urothelial Carcinoma After Renal Transplantation: A Comparison of Surgical and Oncological outcomes
Authors: Zhang Qiming , Ma Runzhuo , Li Youzhao , Lu Min , Zhang Hongxian , Qiu Min , Zhao Lei , Zhang Shudong , Huang Yi , Hou Xiaofei , Ma Lulin 
Published: August 2021

Background: There is currently no consensus on the optimal management of de novo unilateral upper tract urothelial carcinoma (UTUC) in renal transplant recipients. We aimed to compare the surgical and oncological outcomes of simultaneous bilateral radical nephroureterectomy (SBRNU) and unilateral radical nephroureterectomy (URNU) to determine the appropriate surgical method. Methods: Patients who developed de novo UTUC after renal transplantation and underwent surgical treatment at our center were included in the study. Outcomes were compared between the SBRNU group (underwent bilateral RNU within 3 months) and the URNU group using the Mann–Whitney U-test for continuous variables, Pearson’s chi-square test for categorical variables, and the log-rank test for survival data. Results: A total of 48 patients were identified, including 21 and 27 patients in the SBRNU and URNU groups, respectively. Comparison of perioperative data showed that the SBRNU group had a significantly longer operative time ( P < .001) and hospital stay ( P = .040) than the URNU group but no statistically significant difference in the blood loss ( P = .171) and morbidity rate ( P = .798). After a median follow-up of 65 months, the SBRNU group had a significantly longer disease-free survival ( P = .009), longer cancer-specific survival ( P = .032), marginally longer overall survival ( P = .066), and similar intravesical recurrence-free survival ( P = .274) than the URNU group. Conclusions: Our data suggest that SBRNU contributes to improved survival without significantly compromising the perioperative outcomes compared with URNU. SBRNU can be considered a feasible option for de novo UTUC after renal transplantation in specialized centers. Prospective studies should be conducted to further explore the best treatment options for this group of patients.
Swallowing muscle training for oropharyngeal dysphagia: A non-inferiority study of online versus face-to-face therapy
Authors: Bascuñana-Ambrós Helena , Renom-Guiteras Marta , Nadal-Castells Maria Josep , Beranuy-Rodríguez Marta , Perrot-González Jean Claude , Ramirez-Mirabal Eliot , Trejo-Omeñaca Alex , Monguet-Fierro Josep Maria 
Published: August 2021

Introduction The purpose of this study is to show the non-inferiority of the telemedicine therapy versus face-to-face using the exercise therapy of oropharyngeal muscles in 183 patients treated consecutively from 2010 to 2020. Method We conducted a retrospective study comparing two dysphagia treatment groups: online versus face-to-face. Patients were distributed in a non-random way but according to patient's preferences. All patients followed the same pathway and were evaluated at the beginning and at the end of the study using the dysphagia outcome and severity scale and the functional oral intake scale. A non-inferiority analysis approximation was done with delta = 1 in both variables. Results Within a total of 183 patients, 114 (62.3%) used the online treatment and 69 (37.7%) the face-to-face one. The main cause of dysphagia was neurological in the total sample (60.7%) and within both groups. When we evaluate the clinical response, we find that both groups improved regardless of the type of therapy. The confidence interval of the difference between the beginning and the end of treatment did not reach the inferior limit of the delta defined, therefore supporting the no inferiority of online versus presential. Discussion This study shows the no inferiority of the online therapy versus the face-to-face one for the oropharyngeal training of the swallow muscles.
Implementing a novel programme for nurses and allied health professionals to develop capacity for evidence-informed clinical practice
Authors: Cooper Silvie , Sanders Julie , Pashayan Nora 
Published: August 2021

Background Nurses and allied health professionals (AHPs) require skills and support to access, appraise, interpret and use research evidence in clinical practice. We describe the process of designing and implementing the Evidence in Practice (EiP) programme at a UK hospital. Methods Key stakeholders were engaged to identify learning needs and priorities in appraising and implementing research evidence. To address these, we designed a multi-strategy bespoke programme of activities. Results The programme comprised the development of (a) a visual summary of a research paper, (b) five skills development masterclasses and (c) a six-month mentoring scheme to develop and implement plans for translating evidence into practice. Discussion The programme overcame many of the traditional barriers (lack of access, skills and time) to increase engagement of nurses and AHP staff in accessing, reviewing and using evidence in clinical practice. Conclusion With clinical leadership support, it is feasible to use a multi-strategy approach to promote and enable nurses and AHPs to use evidence in clinical practice.