bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seed quality indicators of winter bread wheat accessions depending on the grain size
Authors: Skrypnyk O. O. , Leonov O. Yu. , Shyianova T. P. , Suvorova K. Yu. , Usova Z. V. 
Published: October 2021

Purpose and objectives. To evaluate the effect of sorting seeds by size on their quality indicators: germination energy, laboratory germinability and 1000-grain weight.
Materials and methods. The experiments were carried out in the experimental field of the Plant Production Institute named after V.Ya. Yuriev of NAAS in accordance with the field experimentation method in 2016–2018; 26 winter bread wheat lines and varieties were studied. The varieties and lines were grown in variety trial experiments; the plot area was 10 m2. Seeds were separated on sieves of a laboratory separator RLU-3; the 1000-grain weight was measured; the laboratory germinability and germination energy were determined.
Results and discussion. When winter bread wheat seeds are sorted on sieves, they are separated into fractions with various 1000-grain weights. The separated fractions of winter wheat seeds have different sowing qualities. The 2.5 x 20 mm seeds and 2.8 x 20 mm seeds are of the best quality (germination energy, germinability). It was found that in 2016–2018, the germination energy, laboratory germinability and 1000-gain weight changed depending on the growing conditions. They were the highest in 2017. The varieties with a high 1000-grain weight have been identified: Doskonala, Pryvablyva, Smuhlianka, and Haiok. The highest germination energy and germinability were intrinsic to varieties Yednist, Harmonika and Bunchuk. Yednist (93.3%), Harmonika (94.3%), Metelytsia Kharkivska (94.5%), Bunchuk (94.7%), Alians (93.3%), Podolianka (92.5%), Patriotka (93.6%), Zapashna (93.3%), Dyvo (93.7%), Doskonala (93.6%), Krasa Laniv (94.0%), Smuhlianka (93.1%), and Erythrospermum 408-13 (93.7%) had a high germinability of small seeds (2.2 x 20 mm). To clean these varieties, especially in years with low seed yields, it is recommended to use seeds of the standard size (2.2–2.5 x 20 mm).
Conclusions. The relationships between the grain size and sowing qualities of seeds have been established. Separation of seeds is an effective technological method allowing for selection of top-quality seeds
TO EVALUATE THE FUNCTIONAL OUTCOME OF METACARPAL FRACTURES TREATED BY DIFFERENT TECHNIQUES
Authors: Kumar Amit , Badyal Vinay , Gupta Sanjeev 
Published: October 2021

Background: Metacarpals fractures are most common. Management varies from conservative to operative techniques.
Aim: To evaluate the functional outcome of metacarpal fractures treated by different techniques.
Patients and Methods: a total of 65 fractures in 50 patients managed by various modalities (conservative as well as operative). Functional outcome was assessed by using TAM and DASH scoring system at 6th week, 3rd month and at 6th month.
Results: 62 fractures united and three fractures mal-united at the time of final assessment. Overall excellent and good results were achieved in 90% cases (45 out of 50 cases).
Conclusion: Operative technique is better option in case of unstable fracture and conservative technique is better in case of stable fractures. Finally we concluded that the detailed clinical and radiological assessment of fracture and choosing the correct method of treatment are critical in achieving good results.
Keywords: Metacarpal bones, total active movement (TAM), disability of arm, shoulder and hand score (DASH).
PENGARUH PARTISIPASI ANGGOTA DAN LINGKUNGAN KERJA TERHADAP KEBERHASILAN USAHA KOPERASI KARYA KITA DI SEKRETARIAT DEWAN PIMPINAN PUSAT PARTAI GOLONGAN KARYA
Authors: Sugina Sugina , Sunarya Po Abas , Khairul Khairul 
Published: October 2021

Penelitian ini bertujuan untuk menguji pengaruh partisipasi anggota dan lingkungan kerja secara parsial maupun secara simultan terhadap keberhasilan usaha Koperasi Karya Kita di Sekretariat DPP Partai Golkar, populasi berasal dari Koperasi Karya Kita Sekretariat DPP Partai Golkar dengan metode sampel jenuh sebanyak 62 responden, metode penelitian yang digunakan adalah metode survey secara deskriptif berjenis penelitian kuantitatif, dengan analisis data pengujian validitas dan reliabilitas, uji normalitas dan pengujian regresi sederhana dan regresi berganda meliputi uji model summary, coefficient dan uji anova. Hasil penelitian menunjukkan bahwaterbukti terdapat pengaruh secara simultan Partisipasi Anggota (X1) dan Lingkungan Kerja (X2) terhadap Keberhasilan Usaha Koperasi (Y) berdasarkan nilai t hitung 6.991 > 2.00030 secara signifikan 0.000 < 0.05, terbukti bahwa terdapat pengaruh Partisipasi Anggota (X1) terhadap Keberhasilan Usaha Koperasi (Y) berdasarkan model summary senilai 0,510 atau 26,01% sedangkan sisanya 73,9% dipengaruhi variable lainnya yang tidak diteliti, terbukti bahwa terdapat pengaruh lingkungan kerja (X2) terhadap keberhasilan usaha koperasi (Y) berdasarkan model summary senilai 0,330 atau 10,89% sedangkan sisanya 80,91% dipengaruhi variable lainnya yang tidak diteliti dan terbukti bahwa terdapat pengaruh partisipasi anggota (X1) dan lingkungan kerja (X2) secara simultan terhadap keberhasilan usaha koperasi (Y) berdasarkan model summary senilai 0,870 atau 75,69% sedangkan sisanya 24,31% dipengaruhi variable lainnya yang tidak diteliti
Clinical Profile and Outcome of Children with Congenital Heart Disease in First Year of Life
Authors: Rana Rubina Afroz , Khatoon Soofia , Ahmed Mir Nesaruddin , Islam Md Rafiqul , Kabir Shahreen , Das Nanda Lal , Nahar Zakia , Jebunnesa - , Jobayer Mohammad 
Published: October 2021

Diagnosis of congenital heart disease (CHD) which is a structural abnormality of the heart or intra thoracic great vessels in the earliest possible time is very important. Identifying the various modes of presentation, early referral and appropriate intervention can save lives and reduce risk of complications. The objectives of this study were to determine the clinical profile, complication and immediate outcome of children with congenital heart disease in first year of life. This cross-sectional observational study was conducted from October 2011 to March 2012 among 50 children from zero to one year of age who was diagnosed as CHD by echocardiography admitted in Department of Paediatrics of ShaheedSuhrawardy Medical College, Dhaka and Department of Paediatric Cardiology of National Institute of Cardiovascular Diseases, Dhaka, Bangladesh. Among 50 infants acyanotic CHD was detected in 70% and cyanotic in 30% infants. Major structural defects were venticularseptal defect 34%, patent ductusarteriosus 30%, tetralogy of fallot’s 14%, transposition of great arteries 12%, atrial septal defect 6%. Presenting features were cough 82%, dyspnea 80%, poor weight gain 70%, feeding difficulty 68% and fever 58%. Frequently observed complications were failure to thrive, pulmonary hypertension and heart failure. Among the outcome of CHD 8% cases closed spontaneously, case fatality rate was 8% and the rest were advised accordingly for surgery, intervention and medical management among which 14% had device closure within the study period. High index of suspicion, early diagnosis, close monitoring and timely intervention can reduce complication of CHD.
Bangladesh Med J. 2020 Sept; 49(3) : 17-21
Morphometry of stingless bees (Hymenoptera:Apidae:Meliponini) of the genus Lisotrigona indicates presence of more than one species in India
Authors: Viraktamath Shashidhar , Jha Ashish Kumar , Rao Shubham , Thangajam Rojeet , Roy Jagruti 
Published: October 2021

Morphometry of 53 stingless bees of the genus Lisotrigona collected from seven places in India by using 36 morphological parameters was studied. The data set also included morphometry data of primary types of L. cacciae, L. chandrai and L. revanai for comparison and was subjected to Factor and Canonical Discriminant analysis. All the bees collected from five places formed two distinct clusters in the Factor analysis and five clusters in Canonical Discriminant analysis. In both the methods of analysis primary types of L. cacciae, L. chandrai and L. revanai were placed well separated from each other as well as from other bees. The bees from seven places also differed from the three known species in morphometry and ratios of length and width of parts of the body. Based on these results it is concluded that Indian stingless bees of the genus Lisotrigona consists of more than one species besides L. cacciae. The action of synonymizing L. mohandasi, L. chandrai and L. revanai with L. cacciae appears arbitrary; these three species should be considered valid until supported by male genital morphology or molecular characters.
Seasonal foraging activity of stingless bee Tetragonula travancorica Shanas and Faseeh (Hymenoptera: Apidae: Meliponini)
Authors: Abraham Lincy , Shanas S. 
Published: October 2021

The foraging hive activity of stingless bee Tetragonula travancorica Shanas and Faseeh was studied from November 2018 to August 2019. The activity varied between the seasons, weather conditions and time hours of study. The outgoing and incoming pollen foragers exhibited two peaks in activity, from 0800-1200 h (first) and during 1500-1600 h (second). The activity of incoming non-pollen foragers displayed only one distinct peak between 1000-1200 h except during the southwest monsoon period. The greatest activity was recorded during the dry season (January-May), followed by the south-west monsoon (June-August) and north-east monsoon (November- December) seasons. Maximum overall activity was recorded during hotter months February, March and April while the lowest was observed in January and December. At any season or time, the number of incoming foragers without pollen was greater than pollen foragers.
Herramientas de infraestructura como código: Ansible, Terrafom, Chef, Puppet
Authors: Dominguez-Quintero Luis , Vargas-Lombardo Miguel 
Published: October 2021

Las herramientas de Infraestructura como código (IaC) permiten automatizar las tareas realizadas por los departamentos de IT de forma rápida y dinámica mediante el uso de lenguajes de programación de scripts, que permiten administrar, crear, manipular y distribuir múltiples recursos informáticos a gran escala dentro de una infraestructura de Cloud Computing. Las herramientas de Infraestructura como código Ansible, Terrafom, Chef, Puppet generan una representación virtual de toda la infraestructura física y escalable de una plataforma Cloud Computing y de Centro de Datos, facilitando que esta sea programable y dinámica.
Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma
Authors: Ren Ziyuan , Wang Zhonglin , Gu Donghong , Ma Hanchen , Zhu Yan , Cai Menghua , Zhang Jianmin 
Published: October 2021

Background: Long noncoding RNAs (lncRNAs) crucially modulate DNA damage responses/repair in cancer cells. However, the underlying regulatory role of genome integrity and its clinical value in colon adenocarcinoma (COAD) remains unclear. This study links genome instability to lncRNA using computational biology techniques, in attempt to propose novel biomarkers of immunotherapy outcome, and investigated a potential competing endogenous RNA (ceRNA) as a molecular regulatory mechanism.Methods: TCGA-COAD patients were divided into genome unstable (GU)-like and genome stable (GS)-like clusters via hierarchical clustering to predict immunotherapy outcomes. Multivariate Cox model was established to predict the overall survival rate in COAD patients. Additionally, SVM and LASSO algorithms were applied to obtain hub lncRNAs. A novel genome instability-related ceRNA network was predicted with the Starbase 2.0 database. To better understand how these genes fundamentally interact during tumor progression and development, the mutation analysis and single-gene analysis for each gene was performed.Results: In contrast to those in the GS-like cluster, GU-like-cluster patients demonstrated a higher tumor mutational burden (TMB)/microsatellite instability (MSI), DNA polymerase epsilon (POLE) mutation rate, and immune checkpoint expression, all indicate a greater predictive power for response rate for immunotherapy. The novel prognostic signature demonstrated an outstanding predictive performance (AUC &gt; 0.70). The genes in the genome insatiability-related ceRNA network (including four axes: AL161772.1-has-miR-671-5p (hsa-miR-181d-5p, has-miR-106a-5p)-NINL, AL161772.1-has-miR-106a-5p-TNFSF11, AC124067.4-hsa-miR-92b-3p (hsa-miR-589-5p)-PHYHIPL, and BOLA3-AS1-has-miR-130b-3p-SALL4) were identified as critical regulators of tumor microenvironment infiltration, cancer stemness, and drug resistance. qPCR was performed to validate the expression patterns of these genes. Furthermore, the MSI-high proportion was greater in patients with mutated type than in those with the wild type according to all four target genes, indicating that these four genes modulate genomic integrity and could serve as novel immunotherapy biomarkers.Conclusion: We demonstrated that genome instability-related lncRNA is a novel biomarker for immunotherapy outcomes and prognosis. A novel ceRNA network that modulates genomic integrity, including four lncRNA-miRNA-mRNA axes, was proposed.
New Polyprenylated Acylphloroglucinol Derivatives and Xanthones From Hypericum wilsonii
Authors: Hao Ji , Zhou Tongxi , Ma Yuanren , Deng Jingtong , Cheng Haitao , Wang Qiang , Lin Qinxiong , Yang Xinzhou , Choi Hoyoung 
Published: October 2021

Four new polyprenylated acylphloroglucinol derivatives, hyperwilone A-D (1–4), and two new xanthones, wilsonxanthone A (5) and wilsonxanthone B (6), together with eight known compounds were isolated from the aerial parts of Hypericum wilsonii. Their structures were expounded by comprehensive analysis of the 1D and 2D NMR spectra and HRESIMS. The relative configurations and absolute configurations of 1-6 were determined by NMR calculations and comparing their experimental and computed ECD data. All compounds were evaluated for GLUT4 translocation effects in L6 myotubes. Compound 5 showed the strongest GLUT4 translocation effects with 2.57 folds at a concentration of 30 μg/ml.
Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents
Authors: Costanzo Paola , Oliverio Manuela , Maiuolo Jessica , Bonacci Sonia , De Luca Giuseppina , Masullo Mariorosario , Arcone Rosaria , Procopio Antonio 
Published: October 2021

It is well-accepted that the endogenous antioxidant protection system progressively decays in elderly people, and that the oxidative stress contributes to different neurodegenerative disorders such as Alzheimer’s Diseases (AD). The lower incidence of AD in countries which feature the Mediterranean Diet was associated to the high consumption of extra virgin olive oil and its polyphenolic fraction, in particular hydroxytyrosol. The protective role of these bio-phenols against oxidative stress, suggested that we combine their antioxidant/free radical scavenging activity with donepezil, an active ingredient which has just been approved for the treatment of AD. Different synthetic strategies were tested to conjugate the two different synthons in good yields. Additionally, a nitro-hydroxytyrosol derivative was synthesized to extend the application to other neurodegeneration inflammatory models. Then, their bioactivity was measured in different chemical and biological tests on a human neuroblastoma cell line (SHSY-5Y). Remarkable results on cell viability and the regulation of the redox state of cells were obtained. All hybrids showed negligible cell death under 1 μM and are stable and non toxic. Reactive oxygen species (ROS) measurements showed that the nitro-hybrid was the more effective one at reducing the ROS amount to physiological values. Then, in light of the bio-metal hypothesis of diverse neurodegenerative disorders, we tested these new compounds on the chelation properties of redox-active metals. The nitro-hybrid was able to chelate all of the tested metal cations, suggesting that we propose it as potential lead compound for a new class of neuroprotective antioxidant agents.
Quantitative Estimation on Contribution of Climate Changes and Watershed Characteristic Changes to Decreasing Streamflow in a Typical Basin of Yellow River
Authors: Lv Xizhi , Liu Shanshan , Li Shaopeng , Ni Yongxin , Qin Tianling , Zhang Qiufen 
Published: October 2021

Climate changes and underlying surface of the watershed have affected the evolution of streamflow to a different degree. It is of great significance to quantitatively evaluate main drivers of streamflow change for development, utilization, and planning management of water resources. In this study, the Huangshui River basin, a typical basin of the Qinghai-Tibetan Plateau, China, was chosen as the research area. Huangshui is the largest first-class tributary in the upstream of the Yellow River. Based on the Budyko hypothesis, streamflow and meteorological datasets from 1958 to 2017 were used to quantitatively assess the relative contributions of changes in climate and watershed characteristics to streamflow change in research area. The results show that the streamflow of Huangshui River basin shows an insignificant decreasing trend; the sensitivity coefficients of streamflow to precipitation, potential evapotranspiration, and watershed characteristic parameter are 0.5502, −0.1055, and −183.2007, respectively. That is, 1 unit increase in precipitation would induce an increase of 0.5502 units in streamflow, and 1 unit increase in potential evapotranspiration would induce a decrease of 0.1055 units in streamflow, and an increase of 1 unit in the watershed characteristic coefficient would induce a decrease of 183.2007 units in streamflow. The streamflow decreased by 20.48 mm (13.59%) during the change period (1994–2017) compared with that during the reference period (1958–1993), which can be attributed to watershed characteristic changes (accounting for 73.64%) and climate change (accounting for 24.48%). Watershed characteristic changes exert a dominant influence upon the reduction of streamflow in the Huangshui River basin.
Readiness and Intention for Adapting New Normal COVID-19 Prevention Campaign for Sustainable Response Among Debre Berhan University Student’s During Campus Re-Entry: A Cross-Sectional Study
Authors: Taye Birhan Tsegaw , Mihret Muhabaw Shumye , Tiguh Agumas Eskezia , Dinberu Mesfin Tadese , Kitaw Tebabere Moltot , Tessema Saba Desta , Zerihun Mulualem Silesh , Haile Asalif Beyene , Worku Solomon Adanew , Amogne Fetene Kasahun , Amare Nakachew Sewnet , Demisse Tesfanesh Lemma , Ambaw Yeshinat Lakew , Dagnaw Abebe Mihretie , Ferede Addisu Andualem , Wondie Kindu Yinges , Kebede Azmeraw Ambachew 
Published: October 2021

Background:The COVID-19 pandemic has had a profound effect on the general healthcare system and higher education worldwide. Adapting to the culture of “new normal,” an emerging response to COVID-19, is crucial for public health recovery and learning. This study investigated students' readiness and intention for adapting to the ‘‘new normal’’ COVID-19 prevention campaign during campus re-entry in Debre Berhan university in Ethiopia after the country eases lockdown restrictions.Methods:A cross-sectional study was conducted from 20th to 30th January 2021, among graduate students in Debre Berhan university, Ethiopia. A simple random sampling technique was used to select 423 participants. A structured and pre-tested self-administered questionnaire was used to collect the data and bivariate and multivariable logistic regressions were fitted. Adjusted odds ratio (AOR) with a 95% confidence interval (CI) were used to interpret the strength of association and the statistical significance level was declared at a p-value of ≤0.05.Result:In this study 423 participants were involved. The level of readiness and intention of adapting to the ‘‘new normal’’ prevention campaign were 49.4 and 54.8% respectively. Being a health science student (AOR = 1.82; 95% CI: 1.18, 2.81), being married (AOR = 2.10; 95% CI: 1.1, 4.05), having a smartphone (AOR = 1.84; 95% CI: 1.09, 3.12), and being knowledgeable towards COVID-19 (AOR = 1.56; 95% CI: 1.04, 2.34) were found to be significant factors associated with intention towards adapting to the ‘‘new normal’’ prevention practice. Also, the main reason why participants had no intention to carry out the ‘‘new normal’’ prevention campaign were a shortage of quality required preventive supplies (60%) and those who perceived themselves personally not at risk of COVID-19 (31.3%).Conclusion:In this study, although information on the COVID-19 outbreak is continually evolving, readiness and intention for adapting to the ‘‘new normal’’ COVID-19 prevention campaign were insufficient. It is critical to improve readiness and intention through increasing knowledge and emphasizing the importance of new technologies and handy protective supplies that may encourage the sustainable practice of new norms post-pandemic.
Dynamics of Vascular Protective and Immune Supportive Sphingosine-1-Phosphate During Cardiac Surgery
Authors: Greiwe Gillis , Moritz Eileen , Amschler Katharina , Poppe Annika , Sarwari Harun , Nierhaus Axel , Kluge Stefan , Reichenspurner Hermann , Zoellner Christian , Schwedhelm Edzard , Daum Günter , Tampe Björn , Winkler Martin Sebastian 
Published: October 2021

IntroductionSphingosine-1-phosphate (S1P) is a signaling lipid and crucial in vascular protection and immune response. S1P mediated processes involve regulation of the endothelial barrier, blood pressure and S1P is the only known inducer of lymphocyte migration. Low levels of circulatory S1P correlate with severe systemic inflammatory syndromes such as sepsis and shock states, which are associated with endothelial barrier breakdown and immunosuppression. We investigated whether S1P levels are affected by sterile inflammation induced by cardiac surgery.Materials and MethodsIn this prospective observational study we included 46 cardiac surgery patients, with cardiopulmonary bypass (CPB, n=31) and without CPB (off-pump, n=15). Serum-S1P, S1P-sources and carriers, von-Willebrand factor (vWF), C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) were measured at baseline, post-surgery and at day 1 (POD 1) and day 4 (POD 4) after surgical stimulus.ResultsMedian S1P levels at baseline were 0.77 nmol/mL (IQR 0.61-0.99) and dropped significantly post-surgery. S1P was lowest post-surgery with median levels of 0.37 nmol/mL (IQR 0.31-0.47) after CPB and 0.46 nmol/mL (IQR 0.36-0.51) after off-pump procedures (P&lt;0.001). The decrease of S1P was independent of surgical technique and observed in all individuals. In patients, in which S1P levels did not recover to preoperative baseline ICU stay was longer and postoperative inflammation was more severe. S1P levels are associated with its sources and carriers and vWF, as a more specific endothelial injury marker, in different phases of the postoperative course. Determination of S1P levels during surgery suggested that also the anticoagulative effect of heparin might influence systemic S1P.DiscussionIn summary, serum-S1P levels are disrupted by major cardiac surgery. Low S1P levels post-surgery may play a role as a new marker for severity of cardiac surgery induced inflammation. Due to well-known protective effects of S1P, low S1P levels may further contribute to the observed prolonged ICU stay and worse clinical status. Moreover, we cannot exclude a potential inhibitory effect on circulating S1P levels by heparin anticoagulation during surgery, which would be a new pro-inflammatory pleiotropic effect of high dose heparin in patients undergoing cardiac surgery.