bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudo Comparativo das Demandas de Urgências Cirúrgicas Antes e Durante a Pandemia de COVID-19
Authors: De Campos Cardoso Lizianne , Da Cruz Luiz Ana Laura , Barbosa Medeiros Rafaela , Florido José Gama Tadeu , Pinheiro de Oliveira Sandro , Trovão Queiroz Aline 
Published: November 2021

Com a pandemia de COVID-19, os serviços hospitalares necessitaram desenvolver novos protocolos de atendimento, envolvendo a triagem de pacientes emergenciais e a modificação de práticas cirúrgicas. Vários fatores colaboraram para uma alteração no fluxo dos procedimentos. Este estudo objetiva avaliar as demandas cirúrgicas dos últimos 5 anos comparando com o período de 2020 sob a interferência da pandemia de COVID-19, identificando os impactos do isolamento social, no fluxo de pacientes cirúrgicos no sistema de saúde. Trata-se de estudo longitudinal, retrospectivo de centro único, realizado entre os meses de fevereiro e julho no período de 2016 a 2020. Optou-se pela utilização dos dados disponíveis na plataforma DATASUS, relacionados a todos os serviços, particulares e públicos, de atendimento de emergência e urgência cirúrgica, da cidade de Vassouras-RJ. Para comparação, foram utilizadas as informações equivalentes do DATASUS, referentes ao estado do Rio de Janeiro e Brasil. A análise dos dados referentes a cirurgias de urgência, apresentou alterações claras do número de atendimentos em todos os níveis avaliados. O estudo demonstrou uma redução evidente nos procedimentos no ano de 2020. Em paralelo, foram avaliados os custos gerados às instituições particulares e públicas nos mesmos períodos que tiveram resultados alterados de forma heterogênea. Conclui-se que a pandemia de COVID-19 reduziu o fluxo de cirurgias de urgência de forma direta e indireta no Brasil, Estado do Rio de Janeiro e no município de Vassouras, impactando na redução dos custos relacionados aos procedimentos nos cofres particulares e públicos.
Consolidation in Soft Soil – Case Study on Prefabricated Vertical Drains (PVDs)
Authors: Kuganeswaran Nadarasa , Rahim Afikah , Ali Nazri 
Published: November 2021

Background:
Constructing on soft ground is one of the challenges of geotechnical engineering. The unpredictable behaviour and characteristics of soft soil can cause much damage resulting in high maintenance costs in the post-construction phase.

Objective:
The purpose of this study is to analyse the consolidation process and ground improvement method using surcharge and a prefabricated vertical drain by measuring the accuracy of the prediction settlement value with the actual site settlement results.

Methods:
An effective ground improvement method is the application of a surcharge and prefabricated vertical drains (PVDs). Various methods can be used to predict the settlement effectively, one such method being PLAXIS 3D simulation. A case study on ground improvement works was selected for this research, where PVDs were constructed and implemented at the site. A few undisturbed samples were collected from the site to generate the parameters based on the lab test conducted in the simulation process. This parameter was carefully studied and representing the principal input for the 3D model, which is generated and represents the actual ground improvement method for the selected case study. The analysis was performed using a borehole and soft soil model to generate the diagram. The prediction settlement value was generated from the PLAXIS 3D analysis as the baseline comparing to the actual results. The factors that influence the settlement value, such as the length and spacing of the prefabricated vertical drain, construction method, and soil characteristics, are also discussed.

Results:
A predicted settlement of 2553 mm was generated by the simulation, while the actual settlement outcome at the site was 2096 mm, a difference of 457 mm, and a prediction accuracy of 82.1%.

Conclusion:
The study found that the combination of surcharge and prefabricated vertical drain in the ground improvement worked well. Also, discussed were the factors that influenced the accuracy of the prediction and the site results.
Composition and Quality Standards of Naturally Derived Anti Tan Medicine
Authors: Pal Rashmi Saxena , Pal Yogendra , Wal Pranay , Wal Ankita , Saraswat Nikita 
Published: November 2021

Background:
Tanning nowadays due to pollution, stress, UV rays, and lifestyle has become a major skincare problem. Synthesis of a poly-herbal anti-tan formulation has been performed in this work, and it is evaluated on various parameters.

Objective:
The present work is aimed at the synthesis of herb-based anti-tan medicine and the evaluation of its various parameters for its efficiency as well as stability.

Materials & Methods:
The herbal preparation was prepared in-house according to the proposed composition, using all the natural contents. The dye was evaluated for its different standards.

Results:
The values of various parameters certified the quality standards of the formulation. The parameters were found to be ample enough for the standardization of herbal medicinal formulation.

Conclusion:

The prepared herbal pack was found to be appropriate according to all standards and can serve as a better alternative for treating tanning.
Clinical Outcomes of Laser Asymmetric Keratectomy to Manage Postoperative Adverse Effects–A Retrospective Clinical Trial
Authors: Min Ji Sang , Min Byung Moo 
Published: November 2021

Background:
Laser asymmetric keratectomy reduces the regional asymmetry of corneal thickness.

Objective:
We aimed to describe the clinical outcomes of laser asymmetric keratectomy keratectomy with laser refractive surgery performed to resolve the adverse effects following ophthalmic surgeries.

Methods:
We compared the preoperative and postoperative outcomes and complaints of blurring after performing laser asymmetric keratectomy with laser refractive surgery in 24 eyes of 16 patients with a deviation sum in corneal thickness in four directions >80 µm. Laser asymmetric keratectomy with laser refractive surgery, with full integration of the Vision Up software, was used to analyze the corneal thickness deviation, employed selective laser ablation to create central symmetry on the thicker cornea to reduce regional asymmetry of corneal thickness, simultaneously correcting the refractive power and myopic shift. The pre-and postoperative clinical and topographic findings were analyzed.

Results:
The patients’ age was 37.57±22.30 (range, 23–65) years. The follow-up period was 16.56±3.23 months. The spherical equivalent (p=0.026), sphere (p=0.022), uncorrected distance visual acuity (LogMAR, p=0.045), blurring score (p=0.000), central corneal thickness (p=0.024), sum of deviations in corneal thickness in four directions (p=0.02), distance between the maximum posterior elevation and visual axis (p=0.04), and kappa angle (p=0.031), significantly decreased postoperatively. The efficiency and safety indices were 0.96±0.11 and 1.00, respectively. There was no myopic regression or blurred vision postoperatively.

Conclusion:
Performing laser asymmetric keratectomy with laser refractive surgery improved corneal symmetry and visual acuity and reduced blurring.
Knowledge, Attitudes, and Practices of Optometrists Regarding Low Vision Services in Saudi Arabia
Authors: Ovenseri-Ogbomo Godwin O. , Alghamdi Waleed 
Published: November 2021

Purpose:
To address the human resources challenge for the provision of low vision services in Saudi Arabia, this study sought to investigate the knowledge, attitudes, and practices of optometrists in Saudi Arabia regarding low vision services. The knowledge and attitudes to low vision services can influence the provision of low vision services by optometrists.

Methods:
A prospective cross-sectional survey of optometrists practicing in Saudi Arabia was undertaken using an online questionnaire designed to elicit the opinions of respondents. The online questionnaire was sent out to optometrists on the official mailing list of registered optometrists and those on the mailing list of the Saudi Society of Optometry.

Results:
Only 26.5% of the respondents correctly indicated the correct designation of low vision in terms of visual acuity. Although 95.8% indicated that optical low vision devices could help people with low vision, 81.6% reported that low vision devices were expensive, and 42.9% felt low vision practice was not profitable. Only 10.4% of respondents provide low vision services in their practice. Insufficient training in low vision care was the main barrier militating against the provision of low vision services.

Conclusion:
The pertinent finding in this study is that about a quarter of the respondents could correctly designate low vision in terms of visual acuity using the World Health Organization (WHO) definition. The study concluded that there was poor knowledge, attitudes, and practices of optometrists in Saudi Arabia regarding low vision, which has implications for the provision of low vision services by optometrists.
Nurses’ Views on the Use, Quality, and Satisfaction with Electronic Medical Record in the Outpatient Department at a Tertiary Hospital
Authors: Jaber Mohammad J. , Al-Bashaireh Ahmad M. , Alqudah Ola M. , Khraisat Omar M. , Hamdan Khaldoun M. , AlTmaizy Hind M. , Lalithabai Diana S. , Allari Rabia S. 
Published: November 2021

Background:Many nurses perceive that the Electronic Medical Record (EMR) reduces the workload, improves the quality of documentation, and improves safety and patient care. However, other nurses reported that the system and environment of healthcare might impede EMR documentation at the bedside.Objective:The study aimed to describe the nurses' views of the use, quality, and satisfaction with EMR in daily practice in outpatient settings. Furthermore, the relationships among the use, quality, and user’s satisfaction of EMR were assessed in the study.Methods:The proposed study employed a cross-sectional, descriptive correlational design. Inclusion criteria were nurses willing to participate in the study, fluent in the English language, and have been working in the Outpatient Department for more than three months until the time of study implementation. A self-reported questionnaire with strong validity and reliability was used to assess nurses’ views of use, quality and satisfaction of EMR.Results:The response rate was 77.2% (170 out of 220), 91.2% of the participants were females. Results about the use of EMR have shown positive views ranging from 51.2% to 84.7%, with the lowest scores reported when to write nurse care worksheets (Kardex). For the quality of EMR, the results have shown positive views ranging from 70% to 87.6% with the lowest scores reported related to the EMR system problems and crashes, and for the user’s satisfaction, the results have shown positive views ranging from 76.5% to 87.1%. There were significant positive correlations between the three elements use, quality, and user’s satisfaction of EMR.Conclusion:Participants reported positive views in the domain of use, quality, and satisfaction with EMR. Furthermore, positive correlations were reported between the use, quality, and satisfaction domains of EMR.
Experimental Analysis of Guardrail Structures for Occupational Safety in Construction
Authors: Baruffi Diniane , Costella Marcelo Fabiano , Chamberlain Pravia Zacarias Martin 
Published: November 2021

Background:
Guardrails are structures that protect workers from falling from heights at construction sites.

Objective:
The objective is to evaluate experimental models by applying static and impact loads to wood and steel guardrails.

Methods:
Brazilian and international standards were consulted to define the actions applied to guardrails, which were tested experimentally in three models of each material in a full-size prototype.

Results:
The experimental results indicate that the models studied could support the applied loads, and no local or global system rupture occurred. However, the displacements for the static load of 1500 N/m required by Brazilian RTP 01 for both models did not comply with Brazilian standard NBR 14718 because they had displacements above 20 mm, despite meeting other international standards for static testing and impact testing.

Conclusion:
From the results obtained in the experimental tests, it was possible to verify that the structures withstood the applied loads and could be used safely in civil construction works. However, the load requirements of RTP 01 are excessive, and NBR 14718 is not suitable for checking temporary guardrail structures. This demonstrates the need for the Brazilian standard to be revised to guide the dimensioning and verification of structures in order to adapt to international standards.
Research on Physical Fitness Development for U10 five-a-side Football Teams
Authors: Chau Vinh Huy 
Published: November 2021

Background:
Football is a team sport; players often have fierce ball disputes to limit the opponent's ability, resulting in a lot of physical consumption.

Objective:
To evaluate the professional development of physical fitness for U10 five-a-side football teams, this study introduces several exercises to test and improve their physical strength.

Methods:
We introduce 5 tests, including long jump on the spot, 15-meter sprint, 5x30m sprints, 5-minute running, and 1-minute rope skipping. 6 months of training was divided into 3 phases with four 90-minute training sessions/week. Phase 1 was aimed for the players to adapt to normal training, phase 2 was to develop the maximum focus speed, and phase 3 was to develop professional physical strength.

Results:
The results show that after 6 months of training, the participants’ physical achievements in all tests have witnessed growth. The growth was statistically significant because tcalculated > tstandard at the possibility P < 0.05, especially in the test of rope skipping in one minute with the highest growth rate W = 9.47%.

Conclusion:
The results of this research can be used as a reference and scientific basis of general physical fitness development in football for kids to build training programs and improve their effectiveness.
Comparison of Effects of Two Drugs (Pregabalin & Celecoxib) on 24 hours Post-Operative Pain Intensity in Patients Undergoing Tibia Fracture Surgery
Authors: Eraghi Amir Sobhani , Azizpour Iman , Hajializade Mikaiel 
Published: November 2021

Background:
Celecoxib is widely used in post-operative cases because of its ability to reduce postoperative opioid drug use. Currently, the use of this drug is common in post-operative cases. In various studies, pregabalin was used for the management of pain after spinal surgery to reduce the need for opioids.

Objectives:
Since the treatment of tibia fractures and surgery is painful and has a long-term recovery, this study aimed to compare the effect of two drugs (pregabalin and celecoxib) on pain severity at 24 h postoperatively in patients having tibia fracture surgery. This would mark significant progress in taking the proper drug.

Methods:
In this probability clinical experiment, the sample consisted of 50 patients scheduled for tibia fractures, who were selected from the table of random numbers. Then, the patients were assigned into two groups: celecoxib (Group C) and pregabalin (Group P). In the first group, celecoxib was administered to patients at 1 h pre-operatively at a dose of 200 mg and 1 h post-operatively at a dose of 200 mg. In the second treatment group, patients received pregabalin at 1 h pre-operatively at a dose of 200 mg and 1 h post-operatively at a dose of 200 mg orally. Then VAS (visual analog scale) scores were recorded at 6, 12, and 24 h after surgery. Finally, using SPSS software, qualitative variables were compared according to their percentage by the Chi-square test. For quantitative analysis of variables, the mean value of each group was calculated. The comparison of means was made by t-test.

Results:
The VAS score was considerably lower at 24 hours after surgery in the pregabalin group than in the celecoxib-treated group. However, after 6 and 12 h of surgery, no statistically meaningful difference was observed. A less analgesic effect was observed in the group treated with celecoxib than pregabalin, which was statistically significant.

Conclusion:
Pregabalin improves postoperative pain, and it has more analgesic effects than celecoxib.
Ultrasound-guided Perineural Dextrose Injection for Treatment of Superior Cluneal Nerve Entrapment: Serial Case Report
Authors: Siahaan Yusak M. T. , Herlambang Jessica , Putri Cynthia , Tiffani Pamela 
Published: November 2021

Background:
Superior cluneal nerve entrapment is a neuropathic condition caused by the inclusion of the superior cluneal nerve that contributes to one of the causes of lower back pain leading to high morbidity. Several therapeutic modalities
are available for superior cluneal nerve entrapment, including medications, physiotherapy, perineural injection, and surgery. Perineural injection with 5% dextrose has become therapeutic alternative in many cases of neuropathy, but its long-term effectiveness is unknown.

Case Presentation:
This study described four patients with superior cluneal nerve entrapment with severe pain intensity treated with ultrasonography guided perineural 5% dextrose injection, resulting in significant clinical improvement during the 6-month evaluation.

Conclusion:
Perineural injection can be considered as long-term therapy in patients with superior cluneal nerve entrapment who have failed other conventional therapies.
Current Guidelines for Gender Affirming Care for Transgender
Individuals
Authors: Shadianloo Shervin , Dancyger Ida , Fornari Victor 
Published: November 2021

Background and goals:
The guidelines for transgender care are evolving
and incorporate a multidisciplinary team approach. These roadmaps entail an
understanding of gender development, mental health, and sociocultural factors in
individual and family lives, as well as the specific medical needs in the process of
transitioning and ongoing treatment. New research is continuing to update the best
evidence-based practice. Multiple professional health organizations have published
guidelines. The World Professional Association of Transgender Health has
pioneered the Standard of Care, currently version seven. Other leading
organizations have their own publications with an emphasis on specific relevant
medical needs. In this paper, The World Professional Association of Transgender
Health Standard of Care and the recommendation of multiple psychiatric and
pediatric organizations are reviewed to provide an overview.

Discussion:
Most current guidelines have similar recommendations in providing
care for transgender individuals. The more recent data has shown the benefits of
medical transitioning in youth and updated recommendations in this age group.
Healthcare professionals are encouraged to stay up to date with these current
guidelines. Further research is recommended.
Purification of Drug Loaded Liposomal Formulations by a Novel Stirred Cell Ultrafiltration Technique
Authors: Soni Prakash K. , Saini T. R. 
Published: November 2021

Background:
Presently reported methods for purification of liposomal formulations at
laboratory scale have drawbacks of adversely affecting critical quality attributes (CQAs) of liposomes
such as particle size, PDI, drug entrapment efficiency, etc., and are also not amenable for
large scale processing.

Objective:
The present study was aimed to explore stirred cell ultrafiltration technique as a novel liposome
purification method for removal of unentrapped free drug and excess external aqueous
fluid, maintaining the physical integrity of liposomes.

Method:
Purification of brimonidine loaded liposomes (model formulation) was performed by
stirred cell ultrafiltration method, and its functional performance and impact on liposomal particle
size, PDI, and entrapment efficiency were compared with two widely used laboratory scale methods,
i.e., ultracentrifugation and centrifugal ultrafiltration.

Results:
The novel stirred cell ultrafiltration method demonstrated liposomal purification within
~30 min with complete liposomal recovery showing minimal processing impact, i.e., ˂0.25 fold
rise in particle size, ~0.5 fold rise in PDI, and ~4% loss in % entrapment efficiency, respectively.
Whereas ultracentrifugation and centrifugal ultrafiltration methods resulted in ~4 fold and ˃2 fold
rise in particle size, ˃10 fold and ˃5 fold rise in PDI, and ˃25% and ~6% loss in entrapment efficiency,
respectively.

Conclusion:
The unique and product-friendly operational features of stirred cell ultrafiltration
method demonstrated simple, rapid, and efficient liposomal purification without affecting CQAs of
liposomal vesicles. This method was also evidently found to be product-friendly, rugged, versatile,
and scalable up to large production batch processing, overcoming major drawbacks of presently
used methods.
A Review of Himalayan Medicinal Plants against Cancer
Authors: Joshi Bhuwan C. , Verma Piyush , Juyal Vijay , Sah Archana N. 
Published: November 2021

Background:
Plants contributed numerous novel compounds for prophylactic and curative
medicine to modern science. They are an important source of natural agents used in various
pharmaceutical industries. Himalayan plants are abundant in various secondary metabolites, such
as anthraquinones, flavonoids, tannins, alkaloids, and terpenes. The Himalayan plants are grown in
high altitudes and have around 6500 years old history as traditional medicines.

Aim:
This review article systematically presents information on Himalayan medicinal plants having
anti-cancer potentials.

Methodology:
Around 160 articles were reviewed using online search engines, like PubMed, Scopus,
Google Scholar, Web of Science, and floras of different Himalayan countries.

Results:
An attempt has been made to review anti-cancer plants and active constituents isolated
from several anti-cancerous plants of Himalayan regions. Eighty-three anti-cancer plants are reported
in this review, and a total of twenty-two active chemical constituents, including phenolic compounds,
glycosides, terpenoids, and alkaloids from the plants, were reported active against various
cancer cell lines.

Conclusion:
Several synthetic agents are used to cure cancer, but many undesired side effects occur
during chemotherapy. Hence, the research is going on to investigate natural therapies, such as
the use of plant-derived products in cancer treatment. They may reduce adverse side effects.
Evaluation of Venom as a Promising Tool for Drug Discovery: Focusing
on Neurological Disorders
Authors: Omidi Soodeh , Mehrpouya Masoumeh , Oladnabi Morteza , Azadmehr Abbas , Kazemi-Lomedasht Fatemeh , Yardehnavi Najmeh 
Published: November 2021

:
Venom toxins have specific molecular targets that result in envenomated complications such as neurotoxicity. During evolution, the composition of the venom has been evolved synchronously with the evolution of molecular targets. Venom is an important tool for humans from two different perspectives; venom advantages and disadvantages. Meanwhile, clinical and pharmacological applications of venoms due to their specific targeting and modulation of physiological elements or targets are notable in various disorders. The better understanding of venoms and their composition will improve the practical applications of some toxin-based drugs in drugstoresin the future.