bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Easy‐to‐Install Textile Bending Sensor with High Sensitivity, Linearity, and Multidirection Direction Capability
Authors: Cao Yuying , Shao Hao , Wang Hongxia , Yang Xiao , Gao Qiang , Chen Qian , Fang Jian , Cheng Tinghai , Lin Tong 
Published: September 2021

AbstractThis study develops a full‐textile triboelectric bending sensor using an elastic conductive filament and a textile fabric as a tribopair, separated by two short spacer filaments between them. Bending triggers a triboelectric conversion. Such a sensor device can report bending angles in real time, with high sensitivity (0.0611 V deg−1) and linearity (goodness of fit above 0.986). By integrating multiple devices at the exact location, the sensor assembly can detect bending in different directions. This sensor device can be directly prepared on clothes, just using the clothes as one of the tribocomponents, and the preparation is simple, simply sewing the conductive filament to the targeted location on the clothes. The presence of sensors has little effect on the air permeability and fabric softness. In addition, the device is washable and can be used for multiple cycles without losing sensing ability. As a demonstration, the sensor is directly made on gloves and elbow pads to detect the finger bending and elbow joint movements successfully. Moreover, a two‐channel bending sensor is attached to the human wrist to report wrist bending direction. Such a simple sensor design has great potential to develop low‐cost, flexible, wearable bending devices for various applications.
“Diminishing returns” for leaves of five age‐groups of Phyllostachys edulis culms
Authors: Guo Xuchen , Shi Peijian , Niinemets Ülo , Hölscher Dirk , Wang Rong , Liu Mengdi , Li Yirong , Dong Lina , Niklas Karl J. 
Published: September 2021

AbstractPremiseLeaf mass (M) and lamina surface area (A) are important functional traits reported to obey a scaling relationship called “diminishing returns” (i.e., M ∝ Aα>1). Previous studies have focused primarily on eudicots and ignored whether the age of leaves affects the numerical value of the scaling exponent (i.e., α).MethodsThe effect of age was examined using 1623 Phyllostachys edulis leaves from culms differing in age collected in Nanjing, China. The scaling relationships among leaf A, fresh mass (FM), and dry mass (DM) were evaluated using reduced major axis protocols. The bootstrap percentile method was used to test the significance of differences in α‐values.ResultsOverall, the numerical values of α exceeded 1.0. The scaling relationship between FM and A was statistically more robust than that between DM and A. The scaling exponents of FM vs. A exhibited a “high‐low‐high‐low‐high” numerical trend from the oldest to the youngest age‐group. FM increased linearly as culm age decreased; the leaf DM per unit area (LMA) exhibited a parabolic trend across the age‐groups.Conclusions“Diminishing returns” is confirmed for all but one age‐group of an important monocot species. The relationship between FM and A was statistically more robust than that between DM and A for each age‐group. The FM per unit A decreased with increasing age‐groups, whereas the middle age‐groups had a greater LMA than the oldest and youngest age‐groups. These data are the first to show that the age of shoots affects the scaling relationship between leaf mass and area.
Using ecological trajectories to track long‐term taxonomic and functional changes in benthic shallow soft‐bottom communities (Bay of Saint‐Brieuc, English Channel)
Authors: Sturbois Anthony , Cormy Gaëtan , Le Moal Alexandre , Schaal Gauthier , Broudin Caroline , Thiébaut Eric , Ponsero Alain , Le Mao Patrick , Jones Auriane , Riera Pascal , Gauthier Olivier , Desroy Nicolas 
Published: September 2021

Abstract

Taxonomic and functional trajectories of benthic assemblages were studied in shallow soft‐bottom sediments in the bay of Saint‐Brieuc (Western English Channel). Changes were assessed at different spatial and temporal scales using a macrobenthic dataset based on 38 stations sampled in 1987 and 2019, coupled with data from one station sampled annually between 2005 and 2019 as part of the European Water Framework Directive monitoring programme.
Taxonomic trajectories indicated 1) changes in the structure and distribution of benthic assemblages, 2) an homogenization of the assemblages, and 3) significant functional shifts.
Fishing activities and nutrient enrichment are probably strong drivers of the observed changes, as suggested by the higher mortality rate of fragile, flexible, tubiculous and burrowing species, and the increase in the abundance of opportunistic species in the assemblages. Certain populations of macroinvertebrates seem jointly controlled by climate change and by the aforementioned local factors of disturbance.
The Community Trajectory Analysis framework appears as a new and interesting method to track ecological changes in marine ecosystems by measuring change with respect to a baseline state, to help define ecological recovery (station returning to the initial ecological state) and departure (station presenting increased changes over time), and to analyse trajectory similarity.
According to the degradation of habitat over time, we identify the need for the implementation of knowledge‐based conservation strategies, especially within Natura 2000 sites.
Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis
Authors: Trincianti Chiara , Van Dijkhuizen Evert Hendrik Pieter , Alongi Alessandra , Mazzoni Marta , Swart Joost F. , Nikishina Irina , Lahdenne Pekka , Rutkowska‐Sak Lidia , Avcin Tadej , Quartier Pierre , Panaviene Violeta , Uziel Yosef , Pruunsild Chris , Vargova Veronika , Vilaiyuk Soamarat , Dolezalova Pavla , Ringold Sarah , Garrone Marco , Ruperto Nicolino , Ravelli Angelo , Consolaro Alessandro ,   for the Paediatric Rheumatology International Trials Organisation
Published: September 2021

ObjectiveTo develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor–negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist.MethodsThe cutoffs definition cohort was composed of 1,936 patients included in the multinational Epidemiology, Treatment and Outcome of Childhood Arthritis (EPOCA) study. Using the subjective physician rating as an external criterion, 4 methods were applied to identify the cutoffs: mapping, Youden index, 90% specificity, and maximum agreement. The validation cohort included 4,014 EPOCA patients, patients from 2 randomized trials, and 88 patients from the PharmaChild registry. Cutoff validation was conducted by assessing discriminative and predictive ability.ResultsThe JADAS10 cutoffs were 1.4, 4, and 13, respectively, for oligoarthritis and 2.7, 6, and 17, respectively, for polyarthritis. The cJADAS10 cutoffs were 1.1, 4, and 12, respectively, for oligoarthritis and 2.5, 5, and 16, respectively, for polyarthritis. The cutoffs discriminated strongly among different levels of pain and morning stiffness, between patients who were and those who were not prescribed a new medication, and between different levels of improvement in clinical trials. Achievement of ID and MiDA according to the new JADAS cutoffs at least twice in the first year of disease predicted better outcome at 2 years.ConclusionThe 2021 JADAS and cJADAS cutoffs revealed good metrologic properties in both definition and validation samples, and are therefore suitable for use in clinical trials and routine practice.
Resveratrol‐β‐Lactoglobulin Composite Nanocoating by Layer‐by‐Layer Assembly with Fe(III)‐Tannic Acid Complex
Authors: Cho Yeon Seo , Kim Seulbi , Kim Young‐Kwan , Jin Sung Giu , Park Ji Hun 
Published: September 2021

AbstractResveratrol (3,4’,5‐trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti‐inflammatory and anti‐oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol‐β‐lactoglobulin (R‐BLG) composite nanocoating through a layer‐by‐layer assembly with Fe(III)‐tannic acid nanofilms. The R‐BLG composite nanocoating can be formed in planar and particulate substrates, showing excellent film stability under a broad range of pH values and against enzymatic digestion during a weeklong incubation. We envision that the proteinaceous nanocoating herein could be combined with existing pharmaceutical carrier materials (e. g., microcapsules and nanoparticles) to realize advanced drug delivery systems with an expanded repertoire of hydrophobic drugs.
Prodigiosin production from Serratia marcescens strain CSK and their antioxidant, antibacterial, cytotoxic effect and in silico study of caspase‐3 apoptotic protein
Authors: Sudhakar C. , Shobana C. , Selvankumar T. , Selvam K. 
Published: September 2021

AbstractThe present study emphasizes the production and optimization of prodigiosin (PG) pigment from Serratia marcescens strain CSK, which was isolated from Shevaroy Hills, Salem district, Tamil Nadu, India. The response surface methodology analysis was applied for the optimization process of PG production. The maximum production of PG (2950 mg/L) was obtained at pH 7.0 with the addition of tryptophan (4.0 g/L) and sucrose (3.0 g/L) with 60 h of incubation. Further, the PG was characterized using high‐performance liquid chromatography, Fourier‐transform infrared spectroscopy, and gas chromatography‐mass spectrometry. The purified PG exhibited strong antioxidant and antibacterial activities. Also, PG's cytotoxic effects against human breast cancer (MCF‐7) cells were observed through acridine orange‐ethidium bromide (AO‐EB) and Hoechst staining. Molecular dockingstudies revealed that PG could bind positively to the caspase‐3 (breast cancer protein 1RE1) binding site with a binding energy score of 17.37 kcal/mol. Overall, the novel PG was found to be an anticancer drug for potential applications in the pharmaceutical industry.
Increased body mass index is associated with operative difficulty during robot‐assisted radical prostatectomy
Authors: Shapiro Daniel D. , Davis John W. , Williams Wendell H. , Chapin Brian F. , Ward John F. , Pettaway Curtis A. , Gregg Justin R. 
Published: September 2021

AbstractObjectiveThis study aimed to identify factors associated with surgeon perception of robot‐assisted radical prostatectomy (RARP) difficulty.Patients and MethodsThis study surveyed surgeons performing RARP between 2017 and 2018 and asked them to rate operative conditions and difficulty as optimal, good, acceptable, or poor. These answers were stratified as optimal or suboptimal for this study. Associations between surgeon responses and variables hypothesized to affect surgical difficulty, including anatomic factors such as pelvic diameter and prostate volume:pelvic diameter ratio, were assessed.ResultsBetween November 2017 and September 2018, a total of 100 patients were prospectively enrolled in the study of which 58 cases were rated as optimal and 42 were rated as suboptimal. Of the evaluated variables, only increasing clinical T stage (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.03–2.15, p = 0.03) and increasing body mass index (BMI) (OR 1.14, 95% CI 1.03–1.26, p = 0.01) were associated with increased difficulty; 90‐day complication rates were similar between the optimal and suboptimal cohorts (17.3% vs. 23.8%, respectively; p = 0.5). The number of patients with previous surgery, pelvic diameter, and prostate size:pelvic diameter ratio were not significantly different between cohorts (p > 0.05 for all). Operative time (ρ = 0.23, p = 0.02) and estimated blood loss (EBL) (ρ = 0.38, p = 0.0001) were correlated with suboptimal difficulty.ConclusionThe factors associated with surgeon‐reported RARP difficulty were patient BMI and clinical T stage among surgeons with significant RARP experience. These data should be incorporated into surgical decision making and patient counseling prior to performing a RARP.
Evaluation of prognostic factors in patients with Bell's palsy
Authors: Kafle Dilli Ram , Thakur Sanjeev Kumar 
Published: September 2021

AbstractBackgroundBell's palsy is a common neurological problem that leads to peripheral palsy of the facial nerve. Most patients have a favorable response with or without treatment while some are left with significant facial deformity. Identification of factors which influence the outcome in patients with Bell's palsy may help clinicians counsel better.MethodsA prospective cross‐sectional study was carried out in the Department of Neurology Nobel Medical College, Biratnagar, between February 2020 and February 2021 after obtaining ethical clearance from the institutional review committee. Patients were assessed at the time of presentation to hospital and followed up at 1 week, 1 month, and 3 months after the onset of illness to evaluate for recovery.ResultsSixty‐two (61.4%) of 101 patients had a favorable outcome at the follow up on the third month, achieving H‐B grade 2 or lower, while 33 (32.7%) had moderate dysfunction and 6 (5.9%) had severe dysfunction. The following factors were associated with favorable outcome: younger age of onset (p < .001), lower initial H‐B grade of III or IV (p = .001), lesser degree of amplitude reduction on affected side as compared to unaffected side (p = .001) and absence of hypertension and diabetes. The following factors did not influence outcome at three months: duration of Bell's palsy (p = 0.142), side of face affected, and gender (p = .09).ConclusionsMost of the patients with Bell's palsy have favorable outcomes. Age, hypertension, initial H‐B grade, and extent of facial nerve degeneration as recorded by nerve conduction studies are important predictors of outcome.
Circular economy‐based new products and company performance: The role of stakeholders and Industry 4.0 technologies
Authors: Pinheiro Marco Antonio Paula , Jugend Daniel , Lopes de Sousa Jabbour Ana Beatriz , Chiappetta Jabbour Charbel Jose , Latan Hengky 
Published: September 2021

AbstractWhile the circular economy (CE) attracts attention from scholars and practitioners, the concept has been challenged by claims that the CE may be seen as a vague concept, or a new label for old green management practices. We propose a new approach to study the effects of the CE on company performance: circular product design (CPD). Consequently, this work investigates how Industry 4.0 technologies and stakeholder pressure influence CPD and, in turn, impact on company performance. Data were obtained from firms which develop products in the electric–electronic and equipment (EEE) sectors in Brazil. Our research results indicate that (i) the application of Industry 4.0 technologies favors CPD, in particular artificial intelligence and big data analytics; (ii) pressure from stakeholders can encourage the adoption of circular strategies, specially from suppliers because they are responsible for developing and delivering smart components; and (iii) although the literature may be seen as controversial, there is a positive relationship with regard to the impacts of CE adoption on market performance. Among its main implications, the article also suggests a set of design strategies oriented towards the development of products for the CE.
Life dissatisfaction in Canadians aged 40 and above with cancer and mental health disorders: A cross‐sectional study using the Canadian Community Health Survey
Authors: Roy Danielle Carole , Lun Ronda , Wang Tzu‐Fei , Chen Yue , Wells Philip 
Published: September 2021

AbstractBackgroundLife dissatisfaction varies with different factors––particularly in the presence of chronic conditions, such as cancer. The combination of cancer and mental health disorders may increase life dissatisfaction due to lowered resilience against stress. We sought to determine if life dissatisfaction is higher in Canadians aged 40 and above with cancer compared to the cancer‐free population and if there is a synergistic effect between cancer and mental health disorder on life dissatisfaction.MethodsWe conducted a cross‐sectional study using the 2015–2016 Canadian Community Health Survey. We included 67,294 subjects aged 40+, and evaluated the association between cancer, mental health disorders, and life dissatisfaction using logistic regression and odds ratios (ORs) while adjusting for age, sex, marital status, education level, and chronic conditions. Relative excess risk due to interaction (RERI), attributional proportion due to interaction (AP), and Synergy index (S‐index), were calculated to determine the significance of additive interaction.ResultsCompared to the cancer‐free population, life dissatisfaction was higher in patients with cancer (OR 2.44, 95% CI: 1.88–3.16) and mental health disorders (OR 5.17, 95% CI: 4.56–5.85). The adjusted ORs for life dissatisfaction were 2.45 (95% CI: 1.74–3.43) and 5.17 (95% CI: 4.55–5.87) for cancer and mental health disorders, respectively, but when both conditions were present, the OR increased to 12.50 (95% CI: 8.40–18.62). The results suggested a synergistic interaction (RERI: 5.89 [95% CI: 0.91–10.87]; AP: 0.47 [95% CI: 0.25–0.69]; and S‐index: 2.05 [95% CI: 1.30–3.23]).ConclusionThis study showed higher life dissatisfaction in cancer and mental health disorder patients. A synergistic effect was detected between cancer and mental health disorder on life dissatisfaction. These results suggest cancer patients with mental health disorders require additional support and psychological resources to improve their quality of life.
The beneficial effect of Escalated‐R‐CHOP‐21 for the treatment of diffuse large B‐cell lymphoma in elderly male patients: A propensity‐matched cohort study
Authors: He Hai‐Xia , Gao Yan , Bai Bing , Wang Xiao‐Xiao , Li Ji‐Bin , Huang Cheng , Mao Jia‐Ying , Ping Li‐Qin , Rong Qi‐Xiang , He Yan‐Xia , Huang He , Cai Qing‐Qing , Li Zhi‐Ming , Jiang Wen‐Qi , Huang Hui‐Qiang 
Published: September 2021

AbstractPurposeSome studies have indicated that using 500 mg/m2 rituximab combined with CHOP‐14 may be beneficial for elderly men but not women with diffuse large B‐cell lymphoma (DLBCL). The purpose of this study was to investigate the potential benefit of escalated doses of rituximab with CHOP‐21 as the first‐line treatment in male patients with DLBCL.MethodsWe performed a retrospective cohort study to analyze the survival benefit of rituximab 500 mg/m2 plus the CHOP‐21 regimen (Escalated‐R‐CHOP‐21) as the first‐line treatment compared with using rituximab 375 mg/m2 plus the CHOP‐21 regimen (Standard‐R‐CHOP‐21) in men with DLBCL. We used propensity score matching to maximize the balance of the observed covariables. The primary endpoints of this study were the progression‐free survival (PFS) rate and overall survival (OS) rate at 3 years.ResultsAfter a median follow‐up of 47 months (IQR 31–65), no significant difference in PFS and OS was found for men treated with Escalated‐R‐CHOP‐21 compared with Standard‐R‐CHOP‐21 [3‐year PFS: 69.7% versus 71.9%, p = 0.867; 3‐year OS: 83.0% versus 82.4%, p = 0.660]. After 1:1 propensity score matching, we found that the patients using Escalated‐R‐CHOP‐21 had statistically significant survival benefits relative to Standard‐R‐CHOP‐21 among the 96 matched elderly male patients for 3‐year PFS [75.5% (95% CI 62.8–88.2) versus 58.2% (95% CI 44.3–72.1); p = 0.019] and 3‐year OS [86.6% (95% CI 76.4–96.8) versus 65.8% (95% CI 52.1–79.5); p = 0.017]. However, no differences in survival were observed for younger male patients. Furthermore, the dose effect in PFS of Escalated‐R‐CHOP‐21 was more obvious for elderly male patients with no high‐risk extranodal sites (p = 0.005 and interaction p = 0.030).ConclusionEscalated‐R‐CHOP‐21 could be a safe and effective option for treating elderly male patients with DLBCL. This study provides new insight into optimizing the standard treatment regimen, which may have important therapeutic implications in elderly male patients with DLBCL.
Ressourcenschonung und Kreislaufführung in der Prozessindustrie
Authors: Saulich Katja 
Published: September 2021

AbstractEin effizienter Umgang mit Stoff‐ und Energieströmen stärkt die Wettbewerbsfähigkeit von produzierenden Unternehmen und schont gleichzeitig die Umwelt. Um den Einsatz nicht erneuerbarer Rohstoffe und Energien deutlich zu senken, ist ein Wechsel von einer linearen zu einer kreislaufgeführten Produktionsweise notwendig. In den letzten Jahren wurden verschiedene Kreislaufführungsstrategien entwickelt, bereits umgesetzt oder befinden sich in der Umsetzung. In diesem Beitrag wird ein kurzer Überblick zu Ansätzen für eine zirkuläre Wirtschaftsweise in der Prozessindustrie gegeben.
Inhibition of JMJD6 by 2‐Oxoglutarate Mimics
Authors: Islam Md. Sailful , Thinnes Cyrille C. , Holt‐Martyn James P. , Chowdhury Rasheduzzaman , McDonough Michael A. , Schofield Christopher J. 
Published: September 2021

AbstractStudies on the inhibition of the human 2‐oxoglutarate dependent oxygenase JMJD6, which is a cancer target, by 2‐oxoglutarate mimics / competitors, including human drugs, drug candidates, and metabolites relevant to cancer are described. JMJD6 assays employed NMR to monitor inhibitor binding and use of mass spectrometry to monitor JMJD6‐catalysed lysine hydroxylation. Notably, some clinically applied prolyl hydroxylase inhibitors also inhibit JMJD6. The results will help enable the development of inhibitors selective for human oxygenases, including JMJD6.
Team functioning across different tumour types: Insights from a Swiss cancer center using qualitative and quantitative methods
Authors: Hitz Felicitas , Ribi Karin , Grote Gudela , Kolbe Michaela , Schmitz Christof , Lamb Benjamin W. , Ruhstaller Thomas , Berchtold Peter , Sevdalis Nick 
Published: September 2021

AbstractBackgroundMultidisciplinary care is pivotal in cancer centres and the interaction of all cancer disease specialists in decision making processes is state‐of‐the‐art.AimTo describe differences of MDTMs by tumour type.MethodsTwelve multidisciplinary team meetings (MDTMs) with participation of different cancer disease specialists at a tertiary hospital were assessed by an exploratory sequential mixed method approach with interviews, observations and a survey to address the following five topics: organisational structure and supporting technology; leadership; teamwork; decision‐making, perceived value and motivation. Thirteen persons with different tumour specialities and levels of seniority were interviewed. The 12 MDTMs were observed twice by uninvolved persons and evaluated by the participating physicians with a survey.ResultsThere were no systematic differences between MDTMs for different tumour types with the exception of the non‐disease specific type MDTM, which was the only one for which the organisational structure was not driven by an electronic tool. However, several factors could be identified that generally influenced the functioning of the MDTMs. In particular, the quality of decision‐making was highly dependent on the availability of case‐based information and the presence of relevant cancer disease specialists. Leadership and teamwork were rated as important and were comparable across the MDTM. Team participants' motivation and perceived value of MDTMs was high across all meetings.ConclusionMDTM at a single institution did not demonstrate disease specific characteristics. An effective MDTM, irrespective of the tumour type, can be successfully structured by technical means and a chairperson coordinating the interaction of cancer disease specialists to improve the decision‐making process.