bluuebunny/crossref_metadata_2025_split huggingface dataset:
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation
Authors: Blaudin de Thé François-Xavier , Lassus Benjamin , Schaler Ari W. , Fowler Stephanie L. , Goulbourne Chris N. , Jeggo Ross , Mannoury la Cour Clotilde , Millan Mark J. , Duff Karen E. 
Published: November 2021

AbstractIn Alzheimer’s disease and related tauopathies, trans-synaptic transfer and accumulation of pathological tau from donor to recipient neurons is thought to contribute to disease progression, but the underlying mechanisms are poorly understood. Using complementary in vivo and in vitro models, we examined the relationship between these two processes and neuronal clearance. Accumulation of p62 (a marker of defective protein clearance) correlated with pathological tau accumulation in two mouse models of tauopathy spread; Entorhinal Cortex-tau (EC-Tau) mice where tau pathology progresses in time from EC to other brain regions, and PS19 mice injected with tau seeds. In both models and in several brain regions, p62 colocalized with human tau in a pathological conformation (MC1 antibody). In EC-Tau mice, p62 accumulated before overt tau pathology had developed and was associated with the presence of aggregation-competent tau seeds identified using a FRET-based assay. Furthermore, p62 accumulated in the cytoplasm of neurons in the dentate gyrus of EC-Tau mice prior to the appearance of MC1 positive tauopathy. However, MC1 positive tau was shown to be present at the synapse and to colocalize with p62 as shown by immuno electron microscopy. In vitro, p62 colocalized with tau inclusions in two primary cortical neuron models of tau pathology. In a three-chamber microfluidic device containing neurons overexpressing fluorescent tau, seeding of tau in the donor chamber led to tau pathology spread and p62 accumulation in both the donor and the recipient chamber. Overall, these data are in accordance with the hypothesis that the accumulation and trans-synaptic spread of pathological tau disrupts clearance mechanisms, preceding the appearance of obvious tau aggregation. A vicious cycle of tau accumulation and clearance deficit would be expected to feed-forward and exacerbate disease progression across neuronal circuits in human tauopathies.
Dynasty recognition algorithm of an adaptive enhancement capsule network for ancient mural images
Authors: Cao Jianfang , Yan Minmin , Chen Huiming , Tian Xiaodong , Ma Shang 
Published: November 2021

Abstract
In view of the polysemy of mural images and the style difference among mural images painted in different dynasties as well as the high energy costs of the traditional manual dynasty classification method, which resorts to mural texts and historical documents, this study proposed an adaptive enhancement capsule network (AECN) for automatic dynasty identification of mural images. Based on the original capsule network, we introduced a preconvolution structure to extract the high-level features of the mural images from Mogao Grottoes, such as color and texture. Then, we added an even activation operation to the layers of the network to enhance the fitting performance of the model. Finally, we performed adaptive modifications on the capsule network to increase the gradient smoothness of the model, based on which to optimize the model and thus to increase its classification precision. With the self-constructed DH1926 data set as the study subject, the proposed model achieved an accuracy of 84.44%, an average precision of 82.36%, an average recall rate of 83.75% and a comprehensive assessment score F1 of 83.96%. Compared with modified convolution neural networks and the original capsule network, the model proposed in study increased all the considered indices by more than 3%. It has a satisfactory fitting performance, which can extract the rich features of mural images at multiple levels and well express their semantic information. Furthermore, it has a higher accuracy and better robustness in the classification of the Mogao Grottoes murals, and therefore is of certain application values and research significance.
A hybrid machine learning method for increasing the performance of network intrusion detection systems
Authors: Megantara Achmad Akbar , Ahmad Tohari 
Published: November 2021

AbstractThe internet has grown enormously for many years. It is not just connecting computer networks but also a group of devices worldwide involving big data. The internet provides an opportunity to make various innovations for any sector, such as education, health, public facility, financial technology, and digital commerce. Despite its advantages, the internet may contain dangerous activities and cyber-attacks that may happen to anyone connected through the internet. To detect any cyber-attack intrudes on the network system, an intrusion detection system (IDS) is applied, which can identify those incoming attacks. The intrusion detection system works in two mechanisms: signature-based detection and anomaly-based detection. In anomaly-based detection, the quality of the machine learning model obtained is influenced by the data training process. The biggest challenge of machine learning methods is how to build an appropriate model to represent the dataset. This research proposes a hybrid machine learning method by combining the feature selection method, representing the supervised learning and data reduction method as the unsupervised learning to build an appropriate model. It works by selecting relevant and significant features using feature importance decision tree-based method with recursive feature elimination and detecting anomaly/outlier data using the Local Outlier Factor (LOF) method. The experimental results show that the proposed method achieves the highest accuracy in detecting R2L (i.e., 99.89%) and keeps higher for other attack types than most other research in the NSL-KDD dataset. Therefore, it has a more stable performance than the others. More challenges are experienced in the UNSW-NB15 dataset with binary classes.
Achieving coronal plane alignment in total knee arthroplasty through modified preoperative planning based on long-leg radiographs: a prospective study
Authors: Singh Daria , Patel Kalpeshkumar C. , Singh Ragini D. 
Published: November 2021

Abstract
Purpose
This prospective study was undertaken to examine whether the desired coronal plane alignment of limb and prosthetic components in total knee arthroplasty (TKA) could be achieved precisely using conventional jig-based methods by modifying the preoperative planning of bone resection utilizing long-leg radiographs (LLRs).

Methods
The study included consecutive 245 TKA procedures. Pre- and postoperative radiological variables, i.e., the mechanical axis (hip-knee-ankle [HKA] axis), mechanical lateral distal femoral angle (mLDFA), and medial proximal tibial angle (MPTA), and their outliers were evaluated. Statistical analysis was performed using SPSS version 21.0.

Results
The mean postoperative HKA axis, mLDFA and MPTA was 179.80 ± 1.81° (p < 0.01; 95% CI: 8.09–9.67), 90.35 ± 1.54° (p < 0.01; 95% CI: 1.33–2.02), and 90.26 ± 1.25° (p < 0.01; 95% CI: 4.41–5.20), respectively. The postoperative HKA axis on the coronal plane was 180 ± 3° in 235 knees (95.92%, 4.08% outliers). Femoral and tibial components were implanted in an acceptable position, withing 90 ± 3° of the mechanical axis of the femur and tibia on the coronal plane in 238 (97.14%, 2.86% outliers) and 243 (99.18%, 0.8% outliers) knees, respectively.

Conclusion
Modified preoperative planning for TKA on LLRs is a reliable and consistent method to achieve the desired limb and component alignment on the coronal plane without adding financial or logistical costs.

Level of evidence
II
Outcomes of severe peripartum cardiomyopathy and mechanical circulatory support: a case series
Authors: Kiriyama Yuki , Kinishi Yuki , Hiramatu Daisuke , Uchiyama Akinori , Fujino Yuji , Toda Koichi , Ootaki Chiyo 
Published: November 2021

Abstract
Background
We present three cases of severe peripartum cardiomyopathy (PPCM) that required mechanical circulatory supports.

Case presentation
Case 1: A 33-year-old woman developed acute heart failure (AHF) after normal spontaneous delivery. Intra-aortic balloon pump (IABP) was inserted on postpartum day (PD) 10 with a peripartum cardiomyopathy (PPCM), which was withdrawn on PD 30 after medical treatment including anti-prolactin drugs.
Case 2: A 44-year-old woman developed AHF 1 month after vaginal delivery. IABP or extra-corporeal membrane oxygenation (ECMO) was not effective and a biventricular assist device was inserted. It was withdrawn on PD 85 after improvement of left ventricular ejection fraction (LVEF).
Case3: A 37-year-old woman was transferred with a diagnosis of PPCM. Cardiac function unimproved by IABP or ECMO, and a left ventricular assist device was implanted. It was withdrawn on PD 386 after recovery of LVEF.

Conclusion
All the cases with PPCM recovered after mechanical circulatory supports and resumed social lives.
Impact of COVID-19 on obstetric anesthesia: a systematic review
Authors: Nasr Shrief 
Published: November 2021

AbstractWith an increase in Coronavirus Disease 2019 (Covid-19) incidents around the world, it has become more important than ever to be prepared for the uncertain context of labor and delivery in obstetrics. As medical staff did not encounter such a situation previously, no prior knowledge and guidelines were present to assist them. During the care of obstetric women infected with COVID-19 as well as those who are suspected of COVID-19 infection, there are two objectives, the care of asymptomatic to severely sick pregnant and postpartum women and preventing exposure of medical professionals and others during childbirth hospitalization. The focus of this review is to provide anesthesiologists who are dealing with infected pregnant mothers with some facts or, as data is insufficient, expert opinion, with an emphasis on awareness and optimal medical obstetric anesthesia training. This review will provide possible recommendations for the obstetric anesthesiologists when treating infected obstetric women and these recommendations also help anesthesia providers to prepare themselves for future pandemics.
A spectrum of epididymis and vas deferens anomalies among children with cryptorchidism: a retrospective multi-center study
Authors: Abdelmohsen Sarah Magdy , Osman Mohamed Abdelkader , Takrouney Mohammed Hamada , El Debeiky Mohamed , Hassan Ahmed Badawe G. , Shalaby Mohamed Mahmoud Abd El-Aleem , Baky Fahmy Mohamed A. 
Published: November 2021

Abstract
Background
Vasoepididymal anomalies are not rare among children with cryptorchidism. They may affect fertility following orchiopexy. Herein, we describe the cases of abnormalities of the vas deferens and epididymis in children undergoing orchidopexy for cryptorchidism. Data were collected retrospectively from six centers providing care for patients with undescended testicles from September 2017 to February 2019. All patients whose congenital anomalies of the epididymis or vas deferens were discovered incidentally during operative intervention for cryptorchidism and where photographs of the anomalies were taken were included.

Results
The total incidence of congenital anomalies on the 467 testicles which had operations was 13.2%. Congenital epididymal and vas deferens anomalies were more common on the left side than the right side in patients with cryptorchidism (P = 0.038). Attachment anomalies between the epididymis and testis were the most common epididymal anomaly (36.3%), while a vanished vas deferens was the most frequent vas deferens anomaly (18%). Three patients had absent vas deferens, two had curled vas deferens, two had vas deferens separated from the epididymis, and one had a duplicated vas deferens. Three patients had an epididymal cyst, one had an enlarged appendix of the epididymis, and one had epididymal agenesis.

Conclusion
Attention must be paid during any surgery on an undescended testicle as an anomaly of the vas deferens could lead to unexpected complications. Anomalies of the vas deferens or epididymis that present in cases of cryptorchidism occur mostly on the left side.
The ambulance service advanced practitioner's role in supporting care homes: a qualitative study of care staff experiences
Authors: Harvey Chris , Froggatt Simon , Lightowler Bryan , Hodge Andrew 
Published: November 2021

Background/aims The demand from care homes on NHS services continues to rise, with little evidence of ambulance service contribution in this area. The Yorkshire Ambulance Service provides an advanced practitioner model to support care homes in Sheffield, as an alternative to calling 999. This study investigated the experiences and needs of the care home staff who use the ambulance service advanced practitioner model. Methods This qualitative study conducted semi-structured, face-to-face interviews with 19 staff members from 10 different care home settings. Thematic analysis using a combination of NVivo and manual coding was undertaken. Results The three key themes from the interviews were variations in service demand, the service user's expectations and experience, and benefits to residents. Participants reported that good community services reduced the need to call 999, empowering carers to support residents to remain in the community. Conclusions Care homes require comprehensive services that meet their needs. The advanced practitioner model provided by the ambulance service supports this, preventing unnecessary 999 calls and fitting with other community service provision.
Denoising of the multi-slit streak tube imaging LiDAR system using a
faster non-local mean method
Authors: Li Wenhao , Guo Shangwei , Zhai Yu , Liu Fei , Lai Zhengchao , Han Shaokun 
Published: November 2021

Combined with the characteristic of the multi-slit streak tube imaging LiDAR (MS-STIL)
system where the imaging areas corresponding to each slit do not
interfere with each other, we denoised the streak images by an
improved fast non-local mean filtering algorithm. Experiments were
performed to investigate the effectiveness of the method. The
experimental results show that the spatial resolution of the system is
improved from 22 to 16 mm; the relative distance error is reduced by
an average of 22.76%; and the intensity accuracy improved
significantly when the distance is 10 m. Additionally, the overall
denoising effect is comprehensively verified by long-range target
imaging. The mean square error of the reconstructed depth image and
intensity image are reduced from 0.0836, 0.0067 to 0.0433, 0.0037,
respectively. The applicability of the proposed method was verified
through comparative experiments in different environments.
Historical development of FINCH from the beginning to single-shot 3D confocal imaging beyond optical resolution [Invited]
Authors: Brooker Gary , Siegel Nisan 
Published: November 2021

We chronicle a 15-year development effort of Fresnel incoherent correlation holography (FINCH) since its first description to its current 3D current microscopic wide-field or confocal imaging that doubles optical resolution beyond the Rayleigh limit to about 100 nm in a single snapshot. The path from the original demonstration of FINCH [Opt. Lett. 32, 912 (2007) OPLEDP0146-959210.1364/OL.32.000912] to its current picture-perfect imaging of multicolor fluorescent biological specimens and reference test patterns by fluorescence or reflected light imaging is described.
Spatial cage solitons—taming light bullets
Authors: Mei Chao , Babushkin Ihar , Nagy Tamas , Steinmeyer Günter 
Published: November 2021

Multimode nonlinear optics is used to overcome a long-standing limitation of fiber optics, tightly phase locking several spatial modes and enabling the coherent transport of a wave packet through a multimode fiber. A similar problem is encountered in the temporal compression of multimillijoule pulses to few-cycle duration in hollow gas-filled fibers. Scaling the fiber length to up to 6 m, hollow fibers have recently reached 1 TW of peak power. Despite the remarkable utility of the hollow fiber compressor and its widespread application, however, no analytical model exists to enable insight into the scaling behavior of maximum compressibility and peak power. Here we extend a recently introduced formalism for describing mode locking to the analog scenario of locking spatial fiber modes together. Our formalism unveils the coexistence of two soliton branches for anomalous modal dispersion and indicates the formation of stable spatiotemporal light bullets that would be unstable in free space, similar to the temporal cage solitons in mode-locking theory. Our model enables deeper understanding of the physical processes behind the formation of such light bullets and predicts the existence of multimode solitons in a much wider range of fiber types than previously considered possible.
Freeform OST-HMD system with large exit pupil diameter and vision correction capability
Authors: Cheng Dewen , Duan Jiaxi , Chen Hailong , Wang He , Li Danyang , Wang Qiwei , Hou Qichao , Yang Tong , Hou Weihong , Wang Donghua , Chi Xiaoyu , Jiang Bin , Wang Yongtian 
Published: November 2021

Compactness and light weight, large exit pupil diameter and distance, small distortion for virtual image, and see-through light paths are pivotal factors to achieve a better, wearable experience of optical see-through head-mounted displays (OST-HMDs). In addition, light efficiency of the virtual image light path is an important factor for heat dissipation in HMD devices. This paper presents a new type of OST-HMD optical system that includes three wedge-shaped freeform prisms and two symmetric lenses. Based on a 0.71 in. microdisplay, an OST-HMD prototype with a diagonal field of view (FOV) of 45.3°, an F-number (F/#) of 1.8, an exit pupil size of

12

mm
×
8

mm

, and an eye relief of 18 mm is demonstrated. The maximum value of distortion of the final system is 0.6% and 0.4% for virtual image and see-through light path, respectively. The overall dimension of the optical system per eye is no larger than

30

mm

(
width
)
×
40

mm

(
height
)
×
14

mm

(thickness), and the weight of the optical module including lenses, holder, and microdisplay is 12.8 g. The light efficiency of the virtual image light path is up to 50% higher than those of other OST-HMD optical solutions.
Mid-infrared quasi-BIC resonances with sub-wavelength slot mode profiles in germanium-based coupled guided-mode resonance structures
Authors: Lal Krishna A. S. , Menon Sruti , Prosad Asish , Raghunathan Varun 
Published: November 2021

We experimentally demonstrate a novel quasi-bound state in the continuum (BIC) resonance in the mid-infrared wavelength region with the resonant electric field confined as a slot mode within a low-refractive-index medium sandwiched between high-index layers. The structures studied here comprise coupled amorphous germanium guided-mode resonance (GMR) structures with a top one-dimensional grating layer and bottom uniform layer separated by a low-index silicon nitride layer. The slot-mode profile within the silicon nitride layer with mode field confinement

>
30
%

is achieved as a solution to the electromagnetic wave propagation through the coupled GMR structure with the dominant field component being perpendicular to the layers. The quasi-BIC resonance in symmetric 1D grating structures can be observed even at normal incidence when considering a realistic excitation beam with finite angular spread. The measured transmission peak is found to redshift (remain almost unchanged) under classical (full-conical) mounting conditions. The highest quality factor of

∼
400

is experimentally extracted at normal incidence under a classical mounting condition with a resonance peak at 3.41 μm wavelength. Such slot-mode GMR structures with appropriately chosen low-index intermediate layers can find applications in resonantly enhanced sensing and active photonic devices.
The burden of zoonoses in Paraguay: A systematic review
Authors: Noguera Zayas Liz Paola , Rüegg Simon , Torgerson Paul 
Published: November 2021

Introduction
Underestimation of zoonoses is exacerbated in low and middle-income countries due mainly to inequalities with serious consequences in healthcare. This is difficult to gauge and reduce the impact of those diseases. Our study focuses on Paraguay, where the livestock industry is one of the major components of the country’s economy. Therefore, the rationale of this study was to develop a case study in Paraguay to estimate the dual impact of zoonotic diseases on both the human health and animal health sector and thus determine the societal burden of such diseases.

Methodology/Principal findings
We conducted a systemic review (including a meta-analysis) to assess the burden of zoonoses in Paraguay, including official reports and grey literature of disease incidence and prevalence. We estimated the Disability Adjusted Life Years (DALYs) and Zoonosis Disability Adjusted Life Years (zDALYs) to measure the difference between the current health status and the desired health situation of animals and the Paraguayan population based on 50 zoonotic diseases suggested by the WHO (World Health Organization), OIE (World Organization for Animal Health) and the National Health in Paraguay. The total DALYs represent 19,384 (95% CI: from 15,805 to 29,733), and zDALYs, 62,178 (95% CI: from 48,696 to 77,188). According to the results, the priority pathogens for DALYs are E. coli, Trypanosoma cruzi, Leishmania spp, and Toxoplasma gondii. When we include the additional animal health burden, the most important pathogens are Brucella spp, E. coli, Trypanosoma cruzi, and Fasciola hepatica for zDALYs.

Conclusion/Significance
This is the first study to integrate DALYs and zDALYs with important clues related to the health status of Paraguay. Through DALYs and zDALYs, our perspective becomes more complete because we consider not only human health but also animal health. This is important for setting priorities in disease control, especially in a society where livestock contribute significantly to the economy and to human well-being.
Backwards & In Heels: The Past, Present and Future of Women Working in Film, Alicia Malone (2017)
Authors: Shelton James L. 
Published: November 2021

Review of: Backwards & In Heels: The Past, Present and Future of Women Working in Film, Alicia Malone (2017)
Coral Gables, FL: Mango Publishing Group, 242 pp.,
ISBN 978-1-63353-617-3, p/bk, £12.99
Experimental demonstration of cylindrical vector spatiotemporal optical vortex
Authors: Chen Jian , Wan Chenhao , Chong Andy , Zhan Qiwen 
Published: November 2021

Abstract
We experimentally generate cylindrically polarized wavepackets with transverse orbital angular momentum, demonstrating the coexistence of spatiotemporal optical vortex with spatial polarization singularity. The results in this paper extend the study of spatiotemporal wavepackets to a broader scope, paving the way for its applications in various areas such as light–matter interaction, optical tweezers, spatiotemporal spin–orbit angular momentum coupling, etc.