bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanocomposite complex ZnO in combination with a triazoloazepinium derivative for inhibition of microbial steel corrosion
Authors: Demchenko N.R. , Bondar O.S. , Tkachenko S.V. , Кurmakova І.М. , Kupchuk О.Yu. , Derevianko S.V. 
Published: December 2024

We have established the possibility of using ZnO nanoparticles to inhibit microbial corrosion with simultaneous inhibition of growth and sulfate-reducing activity of bacteria of the corrosive active group. The search for ways to increase the antibacterial and anticorrosive effect of ZnO nanoparticles makes it possible to combine them with substances, in particular, inhibitors-biocides of microbial steel corrosion.
The nanocomposite complex of ZnO nanoparticles and cationic heterocyclic compound (triazoloazepinium derivative) was studied as a biocide and inhibitor of microbial corrosion on steel. The component concentrations are 3 mg/mL and 1 mg/mL accordingly. The experiments were carried out by using a microbiological and corrosion control methods. It has been established that the proposed nanocomposite complex affects the number of bacteria in the plankton and biofilm. In its presence, there is a complete inhibition of the growth of sulfate-reducing bacteria (the most aggressive component of the microbial community) in plankton. Also, the number of denitrifying bacteria and iron-reducing bacteria in plankton decreases by 3 and 4 orders, respectively. The biofilm formed in the presence of the nanocomposite in the culture medium is less dense in terms of the number of bacterial cells of the sulfidogenic community.
Applying Large Language Models to Assess Quality of Care: Monitoring ADHD Medication Side Effects
Authors: Bannett Yair , Gunturkun Fatma , Pillai Malvika , Herrmann Jessica E. , Luo Ingrid , Huffman Lynne C. , Feldman Heidi M. 
Published: December 2024

OBJECTIVE
To assess the accuracy of a large language model (LLM) in measuring clinician adherence to practice guidelines for monitoring side effects after prescribing medications for children with attention-deficit/hyperactivity disorder (ADHD).

METHODS
Retrospective population-based cohort study of electronic health records. Cohort included children aged 6 to 11 years with ADHD diagnosis and 2 or more ADHD medication encounters (stimulants or nonstimulants prescribed) between 2015 and 2022 in a community-based primary health care network (n = 1201). To identify documentation of side effects inquiry, we trained, tested, and deployed an open-source LLM (LLaMA) on all clinical notes from ADHD-related encounters (ADHD diagnosis or ADHD medication prescription), including in-clinic/telehealth and telephone encounters (n = 15 628 notes). Model performance was assessed using holdout and deployment test sets, compared with manual medical record review.

RESULTS
The LLaMA model accurately classified notes that contained side effects inquiry (sensitivity = 87.2, specificity = 86.3, area under curve = 0.93 on holdout test set). Analyses revealed no model bias in relation to patient sex or insurance. Mean age (SD) at first prescription was 8.8 (1.6) years; characteristics were mostly similar across patients with and without documented side effects inquiry. Rates of documented side effects inquiry were lower for telephone encounters than for in-clinic/telehealth encounters (51.9% vs 73.0%, P &lt; .001). Side effects inquiry was documented in 61.4% of encounters after stimulant prescriptions and 48.5% of encounters after nonstimulant prescriptions (P = .041).

CONCLUSIONS
Deploying an LLM on a variable set of clinical notes, including telephone notes, offered scalable measurement of quality of care and uncovered opportunities to improve psychopharmacological medication management in primary care.
Quince textos de Pío Baroja recuperados de la prensa
Authors: García de Juan Miguel Ángel 
Published: December 2024

En esta investigación se presenta y recoge más de una docena de escritos de Pío Baroja procedentes de la prensa caídos en la desmemoria. Su propósito es que acudan a reunirse con otros ya conocidos de su mismo género en unas verdaderas obras completas del escritor vasco. El repertorio que aquí se muestra es producto de pesquisas en varias hemerotecas españolas. Junto a la variedad de su extensión, tres son los asuntos predominantes en ellos: la literatura, desde distintas perspectivas; dos ciudades en que vivió su autor durante algún tiempo, París y San Sebastián; y la elevada consideración en que Pío Baroja tenía a las mujeres.
Kinematic alignment in robotic total knee arthroplasty
Authors: Lychagin A. V. , Gritsyuk A. A. , Kalinsky E. B. , Rukin Ya. A. , Elizarov M. P. , Gritsyuk A. A. , Gavlovsky M. Ya. , Tomboidi K. Kh. , Babaeva M. L. 
Published: December 2024

Introduction There are two main concepts of total knee arthroplasty: mechanical and anatomical alignment of the lower limb axis. Howell et al. (2013) proposed the concept of kinematic alignment, the main idea of which is to preserve the level of the joint line and the axis of the lower limb that patients had before the onset of osteoarthritis. Initially, kinematic alignment was proposed to be performed with individual guides based on the results of CT/MRI scans but they took a long time to manufacture, were difficult to install, broke down, and were quite expensive. Introduction of robotic orthopaedic systems into clinical practice enabled to plan and perform bone resection with high accuracy, to install the components of the implant system according to the necessary concept thus providing new opportunities for the application of kinematic alignment, which was the purpose of our study.Purpose To study the possibilities of a robotic surgical system in performing restricted kinematic alignment in total knee arthroplasty (TKA).Materials and methods A prospective single-center study was conducted in 47 patients (12 men and 35 women) with knee osteoarthritis in Kellgren – Lawrence grades 3–4, an average age of (65.87 ± 7.4) years, an average BMI of (31.3 ± 4.7) kd/m2 , median HKA angle of 175°, median LDFA of 87°, median MPTA of 87°. The patients underwent robotic total knee arthroplasty (RoTKA) with the method of restricted kinematic alignment.Results On the control whole-leg radiographs, the average HKA angle after surgery was (176 ± 1.5)°. In 42.6 % of cases, the deviation from the plan was within ± 1°, the deviation ± 2° in 44.7 % of cases, and in the remaining 12.7 % of cases the deviation was negative.Discussion In the literature, we did not find the results of radiographic evaluation of the HKA angle in the coronal view before and after robotic total knee arthroplasty and their comparison with the results of preoperative planning using the kinematic alignment method of the limb axis. The results we obtained show high accuracy of the implementation of the preoperative plan.Conclusion A personalized approach to TKA with application of an autonomous robotic system effectively provides kinematic alignment of the axis of the lower limb with an accuracy of up to 2° in 87.3 % of patients.
The optimal method of lateral lengthening osteotomy of the calcaneus: CT study in the Russian population
Authors: Gudi S. M. , Semenova D. A. , Vasiliev K. O. , Skuratova L. K. , Luchshev M. D. , Pakhomov I. A. 
Published: December 2024

Introduction In the current professional literature, lengthening of the lateral column is considered to be one of the most effective and pathogenetically sound joint salvage methods for correction of plano-valgus deformity of the foot. The most widely used osteotomies in clinical practice are those of Evans and Hintermann. However, the articular facets of the subtalar joint are at risk of damage due to the variety of their number, shapes and location in different nationalities.The purpose of the work was to reveal the anatomical variants of the structure of the articular facets of the subtalar joint in the Russian population in order to determine the optimal method of lateral lengthening osteotomy of the calcaneus, based on personal characteristics.Material and methods The results of multispiral computed tomography (MSCT) of the feet of 250 patients were analyzed on the basis of the Tsivyan Novosibirsk Research Institute of Traumatology and Orthopedics. After applying the exclusion criteria, the final sample consisted of 150 patients. 3D modeling of their calcaneal bones with visualization of articular facets of the subtalar joint was performed on a workstation using the syngo.via–Siemens Viewer program. Patients were systematized according to the classification of P. Bunning and C. Barnett (1965). On 3D models of calcaneal bones, the distance between the anterior and middle, as well as between the middle and posterior articular facets was measured.Results The anterior and middle articular facets of the subtalar joint were separated (type A) in 40.7 % (61 feet), the remaining 59.3 % (89 feet) had fused anterior and middle facets (type B). Fully fused anterior, middle and posterior facets (type C) were not found. The average distance between the anterior and middle articular facets was 4.2 ± 0.08 mm, and the average distance between the middle and posterior facets was 5.3 ± 0.0027 mm.Discussion Articular facets of type B prevailed in the Russian population. Evans osteotomy will damage them 100 % of the cases. Hintermann osteotomy decreases the chance of their damage. However, the distance between the facets is very small, visualization during osteotomy is difficult, what can lead to damage to the subtalar joint. Thus, the development of a new method for determining and controlling the level of calcaneal osteotomy that would exclude joint damage is an urgent problem for further research.Conclusion Hintermann’s lateral lengthening osteotomy of the calcaneus may be successfully applied in the Russian population with the least complications in the postoperative period and less damage to the articular facets of the subtalar joint.
Diagnostic value of umbilical cord blood culture compared to sepsis screening in high-risk neonates
Authors: Gudagunti Monica M , Desai Raghavendra H 
Published: December 2024

Neonatal septicaemia significantly contributes to neonatal morbidity and mortality, particularly in developing countries. While peripheral venous blood culture and sepsis screening are gold standards for diagnosing early-onset sepsis (EOS), their sensitivity is limited due to small sample volumes, intrapartum antibiotic use, and prior antibiotic administration. Umbilical cord sampling offers advantages such as being painless, requiring less skill, and allowing early, sufficient sampling for faster evaluation and treatment initiation. This study compares umbilical cord blood culture (UCBC) with sepsis screening in EOS among high-risk neonates.To compare the diagnostic performance of UCBC and sepsis screening in neonates at high risk for EOS.A prospective analytical study was conducted from June 2022 to February 2024 on 62 high-risk newborns in KIMS, Hubballi. UCBC samples were collected immediately after delivery, inoculated into BACT/ALERT bottles, and sent for bacterial culture. Upon NICU admission, sepsis screening was performed. Data was analysed using descriptive and inferential statistics, comparing sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of both methods. In this study among 62 neonates, UCBC showed a sensitivity of 57.89%, specificity of 97.67%, positive predictive value of 91.67%, and negative predictive value of 84.00%. The ROC curve (AUC 0.78) indicated moderate diagnostic accuracy compared to sepsis screening. UCBC is an easy to perform and early diagnostic tool in EOS with a high PPV (91.67%). But due to lower sensitivity (57.89%), it should be complemented with additional methods to optimise diagnosis in neonates at risk.
Combined in–office and at-home bleaching of vital teeth in an adolescent patient- A case report
Authors: Dutta Sharbari , Palla Gayatri , Dutta Brahmananda , Mohapatra Abinash 
Published: December 2024

Fluorosis is one of the prevalent causes of discoloration of teeth. Teeth discolouration is a common aesthetic issue which can be caused by various factors, categorized into either extrinsic or intrinsic. Numerous recent advancements are available to manage teeth discoloration effectively. This case report demonstrates a remarkable aesthetic improvement of fluorosed teeth achieved through in-office bleaching, highlighting the procedure’s efficacy in restoring a brighter smile.A twelve-year-old patient with mild to moderate dental fluorosis underwent a conservative treatment to address fluorosis, prioritizing cost-effectiveness and minimal invasiveness. After 3 visits for vital in-office bleaching and at home bleaching showed considerable diminishing of intensity of the discolouration. The combined in-office and home bleaching approach successfully improved the teeth's appearance, meeting both the patient's and parents' aesthetic and practical goals. Studies generally favour in-office bleaching over home methods for longevity and efficacy, though sensitivity levels vary by concentration and desensitizers. For optimal results, professionals are advised to follow manufacturer protocols, maintain the concentration of the bleaching agent, and application time, and combine in-office and at-home treatments for safe, and lasting whitening.Patient was advised to avoid stain-causing foods and maintain good oral hygiene post-treatment, to prevent re-staining and maintain the teeth shade. This case also highlighted the effective management of fluorosis in children.
PENGARUH SUDUT ELEKTRODA 75, 85, 90 PADA LONGITUDINAL ARAH MUNDUR TERHADAP PRESENTASE PENETRASI
Authors: Hafni Hafni , Rifqi Rifqi 
Published: December 2024

Shielded Metal Arc Welding (SMAW) merupakan salah satu dari proses pengelasan cair (fusion welding) yang menghasilkan penyatuan yang homogen elektroda dengan logam dasar (base metal), yang disebabkan oleh busur listrik yang menghasilkan panas tinggi meleburkan elektroda dan logam dasar (base metal) secara bersamaan dan dilindungi oleh gas pelindung dari reeaksi kimia fluk elektroda. Kedalaman fusi (depth of fusion) yang terbentuk ditentukan oleh masukan panas ( heat input) , sudut elektroda dan arah pengelasan.
Penelitian dilakukan di laboratorium Teknik Mesin Institut Teknologi Padang. base metal yang digunakan adalah baja karbon rendah ST 37 dengan ukuran tebal 10 mm , Panjang 100 mm . lebar 100 mm. Pengelasan dilakukan pada permukaan base metal pada posisi bawah tangan (flat position), tipe sambungan (weld type) adalah surfacing weld sebanyak 4 jalur las yang masing masing jalur mempunyai jarak 20 mm. Panjang las 100 mm . spesikasi elektroda AWS E 6013 berdiameter 3,2 mm. Mesin las SMAW arus AC dengan voltage 30 V. current 85 A.
Sudut elektroda yang terukur antara elektroda dengan jalur las yaitu 750, 850, 900. Arah pengelasan mundur dimana eletroda menarik cairan las ke jalur las dan tinggi busur normal dimana jarak elektoda dengan base metal sama dengan diameter elektroda. Dari hasil pengelasan akan diperoleh presentasi penetrasi yaitu perbandingan kedalam fusi dengan lebar.
Hasil penelitian diperoleh kecepatan pengelasan : 2,48 mm/s untuk sudut eletroda 750 , 2,49 mm/s untuk sudut eletroda 850 dan 2,51 mm/s untuk sudut elektroda 90. Heat input untuk sudut elektroda750 adalah 1015,93 J/mm , heat input untuk sudut elektroda 850 adalah 1024,20 J/mm dan heat input untuk sudut elektroda 900 adalah 1015,93 J/mm. Dari perbandingan lebar dengan kedalaman fusi diperoleh ; sudut elektoda 85 mempunyai presentasi penetriasi sebesar 9,85 % lebih baik tinggi dibandingkan dengan sudut elektroda 750 mempunyai presentasi penetriasi sebesar 8,43 %, dan sudut elektroda 900 mempunyai presentasi penetrasi 8,35 %
PENGARUH PENAMBAHAN BAHAN PLASTIK MIKA SEBAGAI FILLER PADA CAMPURAN (AC-WC) DENGAN PENGUJIAN MARSHALL
Authors: Misbah Misbah , Wahyuni Serli 
Published: December 2024

Dalam hal peningkatan perkerasan jalan ada beberapa yang harus di perhatikan, yaitu kualitas agregat yang di gunakan, metode pelaksanaannya, dan kualitas aspal. Cara yang sering digunakan untuk menaikkan mutu aspal adalah dengan menambah bahan aditif. Diantaranya seperti arang, plastik, dan lain-lain. Plastik memiliki banyak manfaat tetapi juga memiliki sisi negatif khususnya limbah plastik. Namun limbah plastik membuka peluang untuk dimanfaatkan di bidang konstruksi jalan raya. Dalam penelitian plastik mika bisa digunakan karena memiliki karakteristik yang termasuk kuat dari jenis plastik yang lain dan lebih elastis jika dipanaskan. Plastik mika bersifat termoplastik, tidak reaktif pada temperatur kamar, kecuali oleh beberapa jenis pelarut yang dapat menyebabkan kerusakan. Pada penelitian ini penulis mencoba untuk mengetahui pengaruh dari penambahan plastik mika dan menentukan karakteristik gradasi agregat terhadap campuran Asphalt Concrete Wearing Course (AC-WC) berdasarkan uji Marshall. Hasil dari pengujian ini menunjukkan bahwa semua percobaan dengan penambahan terhadap pencampuran yang dilakukan untuk penambahan plastik mika sebanyak 0% didapatkan kadar aspal optimum sebanyak 5,50%, pada penambahan sebanyak 2% didapatkan kadar aspal optimumnya 5,50%, pada penambahan plastik mika sebanyak 4% tidak dapat dipergunakan karena dari hasil pengujiannya tidak memenuhi spesifikasi, sedangkan pada penambahan plastik mika sebanyak 6% didapatkan nilai kadar aspal optimum sebanyak 6,25%. Maka, pengaruh penambahan plastik mika yang terbaik pada aspal panas (AC-WC) adalah pencampuran kadar plastik sebanyak 0% dan 2% dengan kadar aspal optimum yang didapat sebesar 5,50%. Untuk nilai Stabilitas, Flow, VMA, dan VFB dengan hasil rata-rata memenuhi spesifikasi yang ditetapkan, sedangkan untuk nilai MQ dan, VIM mengalami peningkatan dan penurunan pada masing-masing persen yang ditentukan, sehingga mempengaruhi hasil dan kinerja dari aspal yang digunakan. Maka, dapat disimpulkan dengan menambah plastik mika pada campuran aspal belum bisa digunakan, diperlukan penelitian lebih lanjut guna mendapatkan hasil yang lebih akurat.
3DCOR.es
Authors: Luque Giraldez Angela , Portolés Morales Manuel Guillermo 
Published: December 2024

En el ámbito técnico, el sector de la impresión 3D ha experimentado un crecimiento anual del 20 % desde 2019 (Aznar, 2022), ya que estas impresoras se han convertido en dispositivos más accesibles para el usuario común. Esta situación conlleva un incremento en la demanda de traducción para esta temática y, especialmente, para el género de las especificaciones técnicas, dado que estos materiales deben traducirse por imperativo legal, según exige la Resolución del Consejo de 17 de diciembre de 1998 sobre las instrucciones de uso de los bienes de consumo técnicos (98/C 411/01). Sin embargo, cabe destacar que en la actualidad no abundan los trabajos relacionados con el ámbito de la traducción técnica, de hecho, BITRA, base de datos de la Universidad de Alicante que recoge bibliografía relacionada con traducción e interpretación, cuenta únicamente con un 0,11 % de publicaciones vinculadas a la traducción técnica. Ante esta ausencia de recursos, creciente necesidad e imperatividad, este trabajo busca describir el diseño e implementación de un sitio web llamado 3DCOR.es con el objetivo de compartir y enriquecer la comunidad de traductores en el uso de nuevas tecnologías en el ámbito de la traducción técnica y la lingüística y en la creación de recursos por el propio traductor. Desarrollada con tecnologías JavaScript, contiene diversos recursos creados en trabajos anteriores, como un glosario bilingüe y bidireccional (inglés-español/español-inglés), un corpus paralelo de especificaciones técnicas de impresoras 3D (inglés-español) que puede interrogarse a través de un gestor de búsquedas y un redactor automático de plantillas de especificaciones técnicas en inglés y español. Adicionalmente, se presentarán ejemplos de cómo utilizar el gestor de búsquedas. Este sitio web será una herramienta valiosa no solo para traductores, sino también para intérpretes, lingüistas, fraseólogos y otros usuarios del sector de la impresión 3D.
The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven cancer
Authors: Yang Jun , Fang Jie , Singh Shivendra , Wells Brennan , Wu Qiong , Jin Hongjian , Janke Laura , Wan Shibiao , Steele Jacob , Connelly Jon , Murphy Andrew , Wang Ruoning , Davidoff Andrew , Ashcroft Margaret , Pruett-Miller Shondra 
Published: December 2024

Abstract

3D cellular-specific epigenetic and transcriptomic reprogramming is critical to organogenesis and tumorigenesis. Here we dissect the distinct cell fitness in 2D (normoxia vs. chronic hypoxia) vs 3D (normoxia) culture conditions for a MYC-driven murine liver cancer model. We identify over 600 shared essential genes and additional context-specific fitness genes and pathways. Knockout of the VHL-HIF1 pathway results in incompatible fitness defects under normoxia vs. 1% oxygen or 3D culture conditions. Moreover, deletion of each of the mitochondrial respiratory electron transport chain complex has distinct fitness outcomes. Notably, multicellular organogenesis signaling pathways including TGFb-SMAD specifically constrict the uncontrolled cell proliferation in 3D while inactivation of epigenetic modifiers (Bcor, Kmt2d, Mettl3 and Mettl14) has opposite outcomes in 2D vs. 3D. We further identify a 3D-dependent synthetic lethality with partial loss of Prmt5 due to a reduction of Mtap expression resulting from 3D-specific epigenetic reprogramming. Our study highlights unique epigenetic, metabolic and organogenesis signaling dependencies under different cellular settings.
Effect of eicosapentaenoic acid on innate immune responses in Atlantic salmon cells infected with infectious salmon anemia virus
Authors: Holmlund Ingrid , Ahmadi Samira , Ruyter Bente , Østbye Tone-Kari , Bou Marta , Gjøen Tor 
Published: December 2024

Abstract

Aquaculture is one of the world's fastest-growing sectors in food production but with multiple challenges related to animal handling and infections. The disease caused by infectious salmon anemia virus (ISAV) leads to outbreaks of local epidemics, reducing animal welfare, and causing significant economic losses. The composition of feed has shifted from marine ingredients such as fish oil and fish meal towards a more plant-based diet causing reduced levels of EPA. The aim of this study was to investigate whether low or high levels of EPA affect the expression of genes related to the innate immune response 48 hours after infection with ISAV. The study includes seven experimental groups: ± ISAV and various levels of EPA up to 200 µM. Analysis of RNA sequencing data showed that more than 3000 genes were affected by ISAV alone (without additional EPA). In cells with increasing levels of EPA, more than 2500 additional genes were differentially expressed. This indicates that high levels of EPA concentration have an independent effect on gene expression in virus-infected cells, not observed at lower levels of EPA. Analyses of enriched biological processes and molecular functions (GO and KEGG analysis) revealed that EPA had a limited impact on the innate immune system alone, but that many processes were affected by EPA when cells were virus infected. Several biological pathways were affected, including protein synthesis (ribosomal transcripts), peroxisome proliferator activated receptor (PPAR) signaling, and ferroptosis. Cells exposed to both increasing concentrations of EPA and virus displayed gene expression patterns indicating increased formation of oxygen radicals and that cell death via ferroptosis was activated. This gene expression pattern was not observed during infection at low EPA levels or when ASK cells were exposed to the highest EPA level (200 μM) without virus infection. Cell death via ferroptosis may therefore be a mechanism for controlled cell death and thus reduction of virus replication when there are enough PUFA in the membrane.