bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel‐Catalyzed Cascade Reactions: Facile Synthesis of Profens
Authors: Yang Peng , Sun Yaxin , Fu Kaiyue , Zhang Li , Yang Guang , Yue Jieyu , Ma Yu , Zhou Jianrong Steve , Tang Bo 
Published: October 2021

AbstractWe report a stereoselective conversion of terminal alkynes to α‐chiral carboxylic acids using a nickel‐catalyzed domino hydrocarboxylation‐transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti‐inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.
Guest‐Driven Light‐Induced Spin Change in an Azobenzene Loaded Metal–Organic Framework
Authors: Xie Kai‐Ping , Ruan Ze‐Yu , Lyu Bang‐Heng , Chen Xiao‐Xian , Zhang Xue‐Wen , Huang Guo‐Zhang , Chen Yan‐Cong , Ni Zhao‐Ping , Tong Ming‐Liang 
Published: October 2021

AbstractStimuli‐responsive materials that can be reversibly switched by light are of immense interest. Among them, photo‐responsive spin crossover (SCO) complexes have great promises to combine the photoactive inputs with multifaceted outputs into switchable materials and devices. However, the reversible control the spin‐state change by photochromic guests is still challenging. Herein, we report an unprecedented guest‐driven light‐induced spin change (GD‐LISC) in a Hofmann‐type metal–organic framework (MOF), [Fe(bpn){Ag(CN)2}2]⋅azobenzene. (1, bpn=1,4‐bis(4‐pyridyl)naphthalene). The reversible trans–cis photoisomerization of azobenzene guest upon UV/Vis irradiation in the solid‐state results in the remarkable magnetic changes in a wide temperature range of 10–180 K. This finding not only establishes a new switching mechanism for SCO complexes, but also paves the way toward the development of new generation of photo‐responsive magnetic materials.
Generation of a π‐Bonded Isomer of [P4]4−by Aluminyl Reduction of White Phosphorus and its Ammonolysis to PH3
Authors: Roy Matthew M. D. , Heilmann Andreas , Ellwanger Mathias A. , Aldridge Simon 
Published: October 2021

AbstractBy employing the highly reducing aluminyl complex [K{(NON)Al}]2(NON=4,5‐bis(2,6‐diisopropylanilido)‐2,7‐di‐tert‐butyl‐9,9‐dimethylxanthene), we demonstrate the controlled formation of P42−and P44−complexes from white phosphorus, and chemically reversible inter‐conversion between them. The tetra‐anion features a unique planar π‐bonded structure, with the incorporation of the K+cations implicit in the use of the anionic nucleophile offering additional stabilization of the unsaturated isomer of the P44−fragment. This complex is extremely reactive, acting as a source of P3−: exposure to ammonia leads to the release of phosphine (PH3) under mild conditions (room temperature and pressure), which contrast with those necessitated for the direct combination of P4and NH3(>5 kbar and >250 °C).
Compensators design for bumpless switching in aero‐engine multi‐loop control system
Authors: Liu Xiaofeng , Luo Chenshuang , Xiong Liuqi 
Published: October 2021

AbstractThe functional requirements of the control system in aero‐engine are increasing due to the multiple objectives. The typical aero‐engine control system is equipped with a multi‐loop control system and switches the controllers to achieve the different performance requirements. However, the aero‐engine fuel flow may be oscillated due to the controllers switch; this phenomenon can seriously damage the performance of the aero‐engine, even its stability. Therefore, the transient switching stability and performance should be concerned. This paper investigates a bumpless compensator design problem for aero‐engine multi‐loop control system. First, a description of the aero‐engine transient bump phenomenon is given, and the design problem is also formulated. Then, we propose a controller compensator method that can smooth the control signal for eliminating the control error. Furthermore, we give the sufficient conditions to guarantee the stability and L1 control problem by using the LMI configuration technique. Moreover, the structure of closed‐loop system with compensators is provided. Finally, a semi‐physical simulation has shown the feasibility of the proposed method.
Metabolic trends of Chinese hamster ovary cells in biopharmaceutical production under batch and fed‐batch conditions
Authors: Rish Adam J. , Drennen James K. , Anderson Carl A. 
Published: October 2021

AbstractExtensive knowledge of Chinese hamster ovary (CHO) cell metabolism is required to improve process productivity and culture performance in biopharmaceutical manufacturing. However, CHO cells show a dynamic metabolism during culturing in batch and fed‐batch bioreactors. CHO cell metabolism is generally described as taking place in three stages: exponential growth phase, stationary phase, and death phase. This review aims to summarize the trends of central metabolism for CHO cells during each stage. Additional insights into how culture conditions are related to phase transitions and force metabolic rewiring are provided. Understanding of CHO cell metabolism lends itself to improving culture qualities by, for example, identifying sources of toxic byproducts and pathways for cellular engineering. In summary, this review describes the changes in CHO cell central metabolism over the course of the culture.
Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles
Authors: Shaaban Saad , Merten Christian , Waldmann Herbert 
Published: October 2021

AbstractAxially chiral atropisomeric compounds are widely applied in asymmetric catalysis and medicinal chemistry. In particular, axially chiral indole‐ and indoline‐based frameworks have been recognised as important heterobiaryl classes because they are the core units of bioactive natural alkaloids, chiral ligands and bioactive compounds. Among them, the synthesis of C7‐substituted indole biaryls and the analogous indoline derivatives is particularly challenging, and methods for their efficient synthesis are in high demand. Transition‐metal catalysis is considered one of the most efficient methods to construct atropisomers. Here, we report the enantioselective synthesis of C7‐indolino‐ and C7‐indolo biaryl atropisomers by means of C−H functionalisation catalysed by chiral RhJasCp complexes.
Impact of mobile devices on cancer diagnosis in cytology
Authors: Santonicco Nicola , Marletta Stefano , Pantanowitz Liron , Fadda Guido , Troncone Giancarlo , Brunelli Matteo , Ghimenton Claudio , Antonini Pietro , Paolino Gaetano , Girolami Ilaria , Eccher Albino 
Published: October 2021

AbstractBackgroundDigital pathology has widened pathologists' opportunities to examine both surgical and cytological samples. Recently, portable mobile devices like tablets and smartphones have been tested for application with digital technologies including static, dynamic, and more recently whole slide imaging. This study aimed to review the published literature on the impact of mobile devices on cancer diagnoses in cytology. This analysis focused on their diagnostic potential, technical details, critical issues and pitfalls, and economical aspects.MethodsA systematic search was carried out in the electronic databases Embase and PubMed. Studies dealing with the application of mobile devices for diagnosing cancer on cytological specimens were included. The quality of studies was assessed with the QUADAS‐2 tool. The main themes addressed were the comparison of manual examination with light microscopy and the use of mobile tools for primary diagnosis. The technical features of different models of smartphones and tablets, software, and adapters were also studied in terms of feasibility and costs‐analysis.ResultsOf 2458 retrieved articles, 18 were included. Concordance with light microscopy was good and diagnostic performance comparable with an expert pathologist's diagnosis. The mobile devices studied differed, sometimes significantly, in terms of speed and cost. The utility was improved by employing specifically designed adapters. Image acquisition and transmission represent the main critical points in almost all studies.ConclusionThe use of mobile devices demonstrated promising results regarding the digital evaluation of cytological samples. Widespread adoption even in underserved areas is anticipated following validation studies, technology improvements, and reduction in the costs.
Electrochemical‐Induced C(sp3)−H Dehydrogenative Trimerization of Pyrazolones to Tripyrazolones
Authors: Ma Jing , Yang Jianjing , Yan Kelu , Sun Xue , Wei Wei , Tian Laijin , Wen Jiangwei 
Published: October 2021

AbstractThe electrochemical‐induced three‐component C(sp3)−H dehydrogenative trimerization of pyrazolones to tripyrazolones with hydrogen evolution has been accomplished under the metal‐ and external‐oxidant‐free conditions. This protocol provides an efficient and eco‐friendly method for the synthesis of tripyrazolones, which avoids the use of metals and stoichiometric chemical oxidants. A wide range of functional groups was tolerated to give selectively the desired products in high yields. Importantly, such an electrochemical‐oxidation‐induced dehydrogenative trimerization reaction could be easily scaled up with excellent efficiency.
Purification and characterization of a novel bacteriocin produced by Acinetobacter movanagherensis AS isolated from goat rectum
Authors: Sharma Vishakha , Aseri Gajender Kumar , Bhagwat Prashant K. , Jain Neelam , Ranveer Rahul C. 
Published: October 2021

AbstractThe present investigation focuses on the purification and characterization of a novel bacteriocin produced by Acinetobacter movanagherensis AS isolated from goat rectum, which demonstrated high antimicrobial activity against both gram‐positive and gram‐negative bacteria. It was identified as A. movanagherensis AS using biochemical and 16S rDNA sequencing. Tryptic soy broth supplemented with 1% yeast extract with pH 6.5 and incubation temperature of 37°C for 32 h were the optimal conditions for bacteriocin production. Bacteriocin was purified in three steps: 70% ammonium sulfate precipitation, ion‐exchange chromatography with diethylaminoethyl‐cellulose resin, and size exclusion chromatography with a Sephadex G75 column. Purified bacteriocin had a recovery of 7.93% with 23.43 purification fold, and a molecular weight of 12.11 kDa was determined by sodium dodecyl sulfate‐polyacrylamide gel electrophoresis analysis. Its biochemical characterization showed good stability at a broad range of temperature (40–80°C) as well as pH (3–9). Inhibition of antimicrobial activity was observed after treatment with trypsin, pepsin, and protease, which confirmed the proteinaceous nature of the purified bacteriocin. Bioinformatic analysis suggests that the purified novel bacteriocin from A. movanagherensis AS may belong to the colicin family. Considering the antimicrobial potential of purified bacteriocin coated on low‐density polyethylene film, we assume that it could be potentially exploited for food preservation in food processing industries.
A parallel attention‐augmented bilinear network for early magnetic resonance imaging‐based diagnosis of Alzheimer's disease
Authors: Guan Hao , Wang Chaoyue , Cheng Jian , Jing Jing , Liu Tao 
Published: October 2021

AbstractStructural magnetic resonance imaging (sMRI) can capture the spatial patterns of brain atrophy in Alzheimer's disease (AD) and incipient dementia. Recently, many sMRI‐based deep learning methods have been developed for AD diagnosis. Some of these methods utilize neural networks to extract high‐level representations on the basis of handcrafted features, while others attempt to learn useful features from brain regions proposed by a separate module. However, these methods require considerable manual engineering. Their stepwise training procedures would introduce cascading errors. Here, we propose the parallel attention‐augmented bilinear network, a novel deep learning framework for AD diagnosis. Based on a 3D convolutional neural network, the framework directly learns both global and local features from sMRI scans without any prior knowledge. The framework is lightweight and suitable for end‐to‐end training. We evaluate the framework on two public datasets (ADNI‐1 and ADNI‐2) containing 1,340 subjects. On both the AD classification and mild cognitive impairment conversion prediction tasks, our framework achieves competitive results. Furthermore, we generate heat maps that highlight discriminative areas for visual interpretation. Experiments demonstrate the effectiveness of the proposed framework when medical priors are unavailable or the computing resources are limited. The proposed framework is general for 3D medical image analysis with both efficiency and interpretability.
Adolescents' satisfaction with care for abortion‐related complications in 11 Sub‐Saharan African countries: A cross‐sectional facility‐based study
Authors: Eboigbe Edua , Gadama Luis , Filippi Veronique , Mehrtash Hedieh , Adu‐Bonsaffoh Kwame , Bello Folasade Adenike , Compaoré Rachidatou , Dossou Jean‐Paul , Idi Nafiou , Kim Caron R. , Msusa Ausbert Thoko , Mugerwa Kidza Yvonne , Wolomby‐Molondo Jean‐José , Tunçalp Ӧzge , Calvert Clara 
Published: October 2021

AbstractObjectiveTo assess satisfaction with care for abortion‐related complications experienced among adolescents compared to older women.MethodsA secondary analysis of the WHO Multi‐Country Survey on Abortion‐related Morbidity and Mortality—a cross‐sectional study conducted in health facilities in 11 Sub‐Saharan African countries. Women with abortion‐related complications who participated in an audio computer‐assisted self‐interview were included. Two composite measures of overall satisfaction were created based on five questions: (1) study participants who were either satisfied or very satisfied across all five questions; and (2) study participants who reported being very satisfied only across all five questions. Multivariable general estimating equation analyses were conducted to assess whether there was any evidence that age (adolescents 12–19 years and older women 20+) was associated with each composite measure of satisfaction, controlling for key confounders.ResultsThe study sample consisted of 2817 women (15% adolescents). Over 75% of participants reported being satisfied or very satisfied for four out of five questions. Overall, 52.9% of study participants reported being satisfied/very satisfied across all five questions and 22.4% reported being consistently very satisfied. Multivariable analyses showed no evidence of an association between age group and being either satisfied or very satisfied (OR 1.07; 95% CI, 0.82–1.41, P = 0.60), but showed strong evidence that adolescents were 50% more likely to be consistently very satisfied with their overall care than older women (OR 1.49; 95% CI, 1.13–1.96, P = 0.005).ConclusionBoth adolescents and older women reported high levels of satisfaction with care when looking at different components of care individually, but the results of the composite measure for satisfaction showed that many study participants reported being less than satisfied with at least one element of their care. Further studies to explore the expectations, needs, and values of women's satisfaction with care for abortion‐related complications are needed.
Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)
Authors: Christou Evangelos , Mastrogianni Sotiria , Bourousis Evangelos , Bachou Theodora , Tsikrikas Theodoros , Mouskou Stella , Voudris Konstantinos , Delis Dimitrios 
Published: October 2021

AbstractIn the last 10 years, an increased number of patients presenting with acute encephalitis is being observed, a finding that is attributed to autoimmune mechanisms. Despite the fact that autoantibodies usually target the neuronal cell surface or synaptic proteins in the central nervous system (CNS), in many cases these remain undetectable, constituting a future diagnostic and therapeutic challenge. Human herpesvirus‐7 (HHV‐7) is proven to be a neurotropic virus, causing various neurological complications mostly in the adult population. We present the case of a 10‐year‐old girl, with confirmed active HHV‐7 infection of the CNS, who developed acute seronegative autoimmune encephalitis. To our best knowledge, there is no literature concerning pediatric cases of autoimmune encephalitis following HHV‐7 infection.
The evaluation of potential global impact of the N501Y mutation in SARS‐COV‐2 positive patients
Authors: Komurcu Selen Zeliha Mart , Artik Yakup , Cesur Nevra Pelin , Tanriverdi Arzu , Erdogan Derya Cakir , Celik Sule , Gulec Elif Yilmaz 
Published: October 2021

AbstractRapid and reliable detection of severe acute respiratory syndrome coronavirus 2 mutations are significant to control the contagion and spread rate of the virus. We aimed to evaluate the N501Y mutation rate in randomly chosen positive patients with the polymerase chain reaction (PCR). The evaluation and analysis of the data with a retrospective approach in cases with mutations, in terms of public health, will contribute to the literature on the global pandemic that affects our society. Public health authorities will take the necessary precautions and evaluate the current situation. The N501Y mutation was detected in patients with positive Covid‐19 PCR test results. The positive samples were examined based on the 6‐carboxy‐fluorescein (FAM) channel in reverse transcription PCR (RT‐PCR) quantitation cycle (Cq) values as low Cq (<25), medium Cq (25–32), and high Cq (32–38) groups. In the study, 2757 (19.7%) of 13 972 cases were detected as mutation suspects and 159 (5.8%) of them were found to have mutations. The ages of the cases with mutations ranged from 1 to 88 years (mean age of 40.99 ± 17.55). 49.7% (n = 79) of the cases with mutations were male, and 50.3% (n = 80) were female. When the RT‐PCR‐Cq results were examined, it was seen that it varied between 11.3 and 35.03, with an average of 20.75 ± 3.32.
Exploitation of virgin olive oil by‐products (Olea europaeaL.): phenolic and volatile compounds transformations phenomena in fresh two‐phase olive pomace (‘alperujo’) under different storage conditions
Authors: Cecchi Lorenzo , Migliorini Marzia , Giambanelli Elisa , Canuti Valentina , Bellumori Maria , Mulinacci Nadia , Zanoni Bruno 
Published: October 2021

AbstractBACKGROUNDMuch effort has recently been spent for re‐using virgin olive oil by‐products as nutraceutical ingredients for human diet thanks to their richness in bioactive phenols, but their management is not easy for producers. We aimed to provide useful information for a better management of fresh olive pomace before drying, by studying the phenolic and volatile compounds transformations phenomena of fresh olive pomace stored under different conditions planned to simulate controlled and uncontrolled temperature conditions in olive oil mills.RESULTSThe evolution of the phenolic and volatile compounds was studied by high‐performance liquid chromatography‐diode array detector mass spectrometry (HPLC‐DAD‐MS) and headspace solid‐phase microextraction gas chromatography‐mass spectrometry (HS‐SPME‐GC‐MS). The phenolic profile varied rapidly during storage: the verbascoside content decreased about 70% after 17 days even at 4 °C, while the content of simple phenols such as hydroxytyrosol and caffeic acid increased over time. The low temperature was able to slow down these phenomena. A total of 94 volatile organic compounds (VOCs) were detected in the fresh olive pomace, with a prevalence of lipoxygenase (LOX) VOCs (78%), mainly aldehydes (19 490.9 μg kg−1) despite the higher number of alcohols. A decrease in LOX volatiles and a quick development of the ones linked to off‐flavors (carboxylic acids, alcohols, acetates) were observed, in particular after 4 days of storage at room temperature. Only storage at 4 °C allowed these phenomena to be slowed down.CONCLUSIONTo preserve the natural phenolic phytocomplex of fresh olive pomace before drying and to avoid off‐flavors development, storage in open containers must be avoided and a short storage in cold rooms (7–10 days) is to be preferred. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Organizational identification and knowledge sharing behavior: Mediating role of organizational citizenship behavior and moderating role of collectivism and leader–member exchange
Authors: Zulfiqar Sehar , Khan Mohammad Saud 
Published: October 2021

AbstractThis study aims at testing an empirical model that investigates the relationship between organizational identification (OI) and knowledge sharing behavior (KSB). Drawing on social identity theory and social exchange theory, this study examines the mediating role of organizational citizenship behavior (OCB) in the relationship between OI and KSB. We also examined how collectivism and leader–member exchange (LMX) moderated the OI and KSB relationship. Data of the study consisted of self‐reported responses of employees (N = 497) of leading Pakistani banks. The hypothesized model was tested, using PROCESS macros by Hayes. The results indicated OI as a significant predictor of KSB and OCB fully mediated this relationship. Moderating role of collectivism turned out to be insignificant in the relationship between OI and KSB. However, the results confirmed the moderating role of LMX in the OCB and KSB linkage. Theoretical and managerial implications of the study along with limitations and directions for future research are also discussed.
Satellite remote sensing analysis to monitor revegetation in the Yangtze River basin, China
Authors: Li Boyan , Wang Yunchen , Wang Wei , Wang Chao , Lin Aiwen 
Published: October 2021

AbstractRevegetation programmes aim to avoid land degradation, control soil erosion, reduce floods, and improve ecological conditions. China has planted billions of trees over the past 20 years. However, little is known about the effectiveness of this artificial revegetation and its consequences on China's national conservation policies and changes in biophysical factors at the county level. Here we use satellite time series data and develop a new metric, the revegetation index (RVI), that quickly monitors revegetation and its long‐term changes. We found that the number of regions where the Grain to Green Program (GTGP) was successfully implemented was only about 55.8% of the areas of GTGP implementation. Surprisingly, we provide observational evidence that the implementation of the GTGP can decrease soil erosion and drought, and increase water availability, but revegetation in the Yangtze River basin (YRB) in China has a limited impact on soil erosion, water, and drought. In particular, for revegetation between 1999 and 2016, indicating that a previous assessment by the Government revealed as official statistics may have overestimated the effects of the ecological restoration practices.