bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the health status of women with genital prolapse
Authors: Teleeva G. I. , Tselkovich L. S. , Balter R. B. , Ivanova T. V. , Ibragimova A. R. , Ryabov A. Yu. 
Published: January 2021

Introduction. In recent years, more and more attention has been paid to the issues of genital prolapse. This is largely due to the increase in women life expectancy and the need to provide them with a decent quality of life, as prolapse is quite often accompanied by dysfunction of the pelvic organs. In recent years, there has been an increasing amount of literature on undifferentiated connective tissue dysplasia (UCTD). However, most of these studies consider therapeutic or vertebro-neurological problems, while the high prevalence rates of this pathology call for additional research on the pathogenetic mechanisms of the effect of UCTD on pelvic organ prolapse, which will allow us to decide on the choice of subsequent treatment.The purpose and objectives. Asess the effect of undifferentiated connective tissue dysplasia (UCTD) on the formation of disorders of the somatic, gynecological and reproductive health status in women with genital prolapse.Materials and methods. To achieve this goal, we examined 204 women with genital prolapse in the POP-Q classification of stage 2–3, of which 97 were diagnosed with UCTD (the main group), and the remaining 107 patients made up the comparison group.Results. To evaluate the influence of UCTD on the formation of somatic, gynecological and reproductive health disorders in women with genital prolapse. We analyzed anamnestic indications for somatic, gynecological and reproductive pathology of women, as well as assessed the current state of health of patients with genital prolapse. It was found that it is UCTD that determines the development of a particular form of gynecological pathology and affects the formation of genital prolapse.Conclusion. UCTD manifests as various forms of somatic and gynecological health disorders throughout the life of women with genital prolapse.
A Comparison of Neurocognitive Decline in Older Adults in Same-Sex and Opposite-Sex Relationships
Authors: Manca Riccardo , Venneri Annalena 
Published: January 2021

Background:
Individuals from sexual minorities experience health inequalities that have
detrimental impacts on their health, especially in the elderly, by exacerbating care needs and symptoms
of chronic conditions such as Alzheimer’s disease (AD). Neurocognitive decline due to AD in the sexual
minority population remains under-investigated. However, being in a relationship may mitigate the
risk of experiencing cognitive impairment.

Objective:
The aim of this study was to investigate whether cognitive decline and brain atrophy may
differ in people from sexual minorities.

Methods:
Clinical data for this study were selected from the National Alzheimer’s Coordinating Center’s
Uniform Data Set and structural MRI data collected across 14 Alzheimer’s Disease Centers.
Eighty participants including 20 patients with AD and 20 healthy controls (HC) in same-sex relationships
were identified and matched to groups of participants (20 AD and 20 HC) in opposite-sex relationships.
The effects of diagnosis and relationship were investigated on all measures.

Results:
No diagnosis-by-relationship interactions were found on any variable. However, post hoc
analyses revealed that the opposite-sex group had grey matter atrophy mainly in medio-temporal areas.
In the same-sex group, atrophy also extended to pre-frontal and cingulate areas. The severity of neuropsychiatric
symptoms correlated with volume of pre-frontal and insular/temporal areas only in the
same-sex group.

Conclusion:
Neurocognitive decline due to AD may express similarly across individuals, independently
of relationship type, thus suggesting a protective role of relational status. However, the same-sex
group appeared to be more likely to experience at least one neuropsychiatric symptom and to have
atrophy extending to fronto-limbic areas.
Curcumin Reverts the Protein Differential Expression in the Liver of the
Diabetic Obese db/db Mice
Authors: Pérez-Vázquez Victoriano , Silva-Gaona Oscar Gerardo , Guzmán-Flores Juan Manuel , Hernández-Ortiz Magdalena , Vargas-Ortiz Katya , Ramírez-Emiliano Joel , Encarnación-Guevara Sergio 
Published: January 2021

Background:
In type 2 diabetic mouse liver, hyperglycemia, and insulin modify gene expression. Curcumin is a
powerful antioxidant and antidiabetic agent that regulates the gene expression of different signaling pathways through
various transcription factors. Therefore, we hypothesized that curcumin modifies the protein expression profile in the liver
of diabetic db/db mice.

Objective:
To determine the effects of curcumin on the liver protein profile of diabetic db/db mice.

Methods:
db/db and wild type (WT) male mice were allocated in four groups, and they were fed for eight weeks. Three WT
and three diabetic db/db mice received a standard diet (SD; WT and db/db groups, respectively); three WT and three
diabetic db/db mice received a SD supplemented with 0.75 % (w/w) curcumin (WT+C and db/db+C groups, respectively).
Liver proteins were separated by 2D electrophoresis. Differential protein expression analysis was performed on
ImageMaster 2D Platinum software, and selected proteins were identified by MALDI-TOF-MS and subjected to enrichment
analysis using STRING and DAVID databases.

Results:
Thirty-six proteins with differential expression due to the diabetic background and curcumin treatment were found;
these proteins participate in the metabolism of amino acids, carbohydrates, and lipids. Interestingly, the altered expression of
seven proteins was prevented in the liver of the diabetic mice that received curcumin.

Conclusions:
Among all differentially expressed proteins, curcumin reverted the altered expression of seven proteins. Thus,
although it was observed that curcumin did not affect the biochemical parameters, it does modify the expression of some
liver proteins in diabetic mice.
Concomitant Diagnosis of Fibromyalgia and Ankylosing Spondylitis: Relation to Clinical Features and Plasma Pentraxin -3 Level
Authors: Baraka Eman , Balata Mona , Ahmed Shereen , El-Blbehisy Mona , Elattar Enas 
Published: January 2021

Background:
Ankylosing spondylitis (AS) is a chronic systemic inflammatory rheumatic
disease that specifically affects the spine and sacroiliac joint. AS diagnosis is often delayed in
the clinical practice and this delay may cause the patients to miss the chance of early treatment. Fibromyalgia
(FM) is a frequently encountered clinical syndrome, fibromyalgianess is a term used
when patients who are diagnosed with inflammatory arthropathies meet the criteria for FM syndrome
as shown in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren syndrome,
and AS.

Objectives:
We aimed primarily to assess the frequency of concomitant diagnosis of FM syndrome
in AS patients and study its impact on clinical disease aspects. Secondary, our aim extended as a
preliminary pilot study to assess the Plasma Pentraxin-3(PTX-3) as a potential marker for the diagnosis
of FM syndrome in AS patients.

Methods:
Plasma PTX-3 in 61 AS patients was compared to 60 matched controls. FM was diagnosed
by FM Rapid Screening Tool.

Bath AS disease activity index (BASDAI) and AS disease assessment score using C- reactive protein
(ASDAS-CRP), Bath AS functional impairment index (BASFI), Bath AS metrology index
(BASMI), AS quality of life (ASQoL) scale, Beck Depression Inventory, and Bath AS Radiology
Index (BASRI) were assessed.

Results:
The patients were categorized into two groups according to the concomitant diagnosis of
FM syndrome. Group I included 14 (22.9%) AS patients who fulfilled the clinical diagnosis of FM
syndrome. Group II included 47 (77.1%) AS patients without FM syndrome. AS patients with FM
(Group I) had significantly(p<0.001) increased an average of ages, disease duration, diagnostic delay
of AS, switching of bDMARDs, morning stiffness duration, ASDAS-CRP, BASFI, ASQoL
score, BASDAI (p=0.008), and BDI score (p=0.005) compared to AS patients without FM (Group
II). PTX-3 levels were significantly (p<0.001) higher in Group I (p<0.001) (median, 0.23; IQR,
0.15-0.41 ng/ml) than Group II (median, 0.13; IQR, 0.035-0.21ng/ml) which showed no significant
differences (p>0.05) compared to the controls. PTX-3 levels had significant positive correlations
(p<0.05) with disease duration, BASFI, and ASQOl. Age, female sex, switch of biologic, ASDAS -
CRP, and PTX-3 were significant predictors of FM in AS patients.

Conclusion:
These results indicate that concomitant FM is a significant problem in patients with
AS and its presence is associated with higher disease activity, impaired function as well as an overall
negative impact on QoL. Easy scanning of suspicious cases of FM with FiRST questionnaire
can be done in daily practice. PTX-3 is more or less accurate as the clinical features to improve the
diagnostic certainty of FM in the presence of AS with a proven sensitivity of 62.3%, a specificity
of 90%, a positive predictive value of 82.75%, and a negative predictive value of 73.9%.
The Appearance of Middle Meningeal Artery Fistulae After Willis Covered Stent for Traumatic Carotid-cavernous Fistulae: Two Case Reports
Authors: Wang Ting , Richard Seidu A. , Zhang Changwei , Xie Xiaodong , Wang Chaohua 
Published: January 2021

Introduction:
Carotid cavernous fistulae (CCF) are rare, and they occur when there is
a communication between the internal carotid artery (ICA) and cavernous sinus. These lesions are
associated with blunt or penetrating traumatic injuries of the carotid arteries. We present the first
cases of cavernous dural arteriovenous fistulae (cDAVF) in the middle meningeal artery (MMA) after
the treatment of direct CCF in the ICA with Willis-covered stents (WCSs).

Case Presentations:
Our patients comprised 22 and 50-year-old males with histories of head injuries
months before admission at our facility. In both patients above, cerebral angiography revealed
fistulae in the right ICA and left ICA, respectively. They were treated with WCSs via the
trans-artery endovascular route. In both cases, the treatments were not in the way attempted via the
MMA. Subsequently, they developed cDAVF in the middle meningeal artery (MMA), which were
treated with Onyx Liquid Embolic System (Onyx HD-500) (Covidien / ev3 Neurovascular) and
conservatively, respectively.

Conclusion:
These are the first cases in whom WCSs for the management of direct CCF resulted
in cDAVF at the MMA. The WCSs inside the ICA could have resulted in the cDAVF via unknown
mechanisms but not iatrogenic.
The First Case Report of Kabuki Syndrome from the National Iranian Registry of Primary Immunodeficiencies
Authors: Safarirad Molood , Ganji Ali Abbaszadeh , Fekrvand Saba , Yazdani Reza , Motlagh Ahmad Vosughi , Abolhassani Hassan , Aghamohammadi Asghar 
Published: January 2021

:
Kabuki syndrome is a rare congenital anomaly/mental retardation syndrome characterized by intellectual disability, developmental delay, short stature, facial dysmorphic features including ectropion of the lateral third of the lower eyelids and long palpebral fissures, and prominent finger pads. Pathogenic variants of KMT2D (MLL2) and KDM6A are found to be the major causes of Kabuki syndrome. Here, we report the first Iranian case with Kabuki syndrome with an IQ of 79, two episodes of viral pneumonia and distinctive facial features, prominent ears and persistent fetal fingertip pads. These characteristics raised our suspicion for performing whole-exome sequencing (WES), which revealed 2 heterozygous pathogenic missense variants in the KMT2D gene: c.C10024T in exon 34 leading to p.R3342C and c.G15005A in exon 48 leading to p.R5002Q. Hence, the definitive diagnosis of Kabuki syndrome was made based on molecular findings along with the intellectual disability and characteristic facial features.
Vitagenic Effect of Specific Bioactive Fractions of Rhodiola with Trachurus sp. Extract Against Oxidative Stress-Induced Aging in Human Amnion Derived Epithelial Cell Line: In View of a Novel Senolytic
Authors: Marotta Francesco , Thandavan Sathya Priya , Pathak Surajit , Sriramulu Sushmitha , Jothimani Ganesan , Gunasekaran Dharanivasan , Markandeyan Devaprasad , Banerjee Antara 
Published: January 2021

Background:
Rhodiola rosea is a herb that has been used in traditional medicine for
several years, and LF is a class of lipoproteins derived from the fish Trachurus sp. (LF-T), which
exhibits known anti-inflammatory activity.

Objective:
Investigating the anti-aging effect of Rhodiola specific bioactive fractions cluster in
combination with LF-T (R-L compound) in H2O2 mediated oxidative stress-induced human amnion
derived epithelial cell line - FL cells as normal human cell line.

Methods:
FL cells were treated with H2O2 to induce cellular aging, followed by treatment of the RL
compound to study its anti-aging characteristics. Based on the proliferation rate, 0.05% and 0.1%
concentration of R-L compound was determined using MTT assay. Anti-aging and anti-oxidant assays,
ABTS, DPPH, Hyaluronidase activity Nitric Oxide, Lipid Peroxidase, and Superoxide Dismutase
were performed. qPCR for anti-aging genes and matrix metalloproteinase genes were analyzed.

Results:
FL cells treated with R-L compound exhibited increased proliferation rate and free-radical
reduction. Decreased Hyaluronidase enzyme activity and regulation of genes such as SIRT1,
KLOTHO, SERPINA 6, MMP 9, and MMP 2 expression depicted the anti-aging role of the R-L
compound. Chemometric profiling of the R-L compound revealed that aromatic compounds and
unsaturated fatty acids along with their derivatives, were present predominantly, which might have
attributed to the potent oxidative stress impeded aging activity.

Conclusion:
Specific Bioactive Fractions of Rhodiola in combination with LF-T obtained from
Trachurus sp. involve in the regulation of aging genes and might be a novel approach to prevent
the cells from oxidative stress damage and also it might avert the aging of cells.
Survival analysis to assess the length of stay of novel coronavirus (COVID-19) patients under Integrated Medicine - Zinc, Vitamin C & Kabasura Kudineer (ZVcKK)
Authors: Nirmala A. , Ravikumar T. , Kanakavalli K. , Pathiban P. , Babu K. , Jamuna D. , Dhanam C. , Sathiyarajeswaran P. , Vinod N. P. , Devi M. S. Shree 
Published: January 2021

Objective:
COVID19 pandemic out of all odds has created an opportunity to offer treatment in an integrative
manner. This study measures the Length of stay (LS) of patients in an integrative way, as done earlier in China and Vietnam.
Length of stay, Clinical presentations, and Comorbidities were analyzed among COVID19 patients in ESI Hospital, Coimbatore, Tamil Nadu, India.

Method:
Retrospective cross-sectional data on 251 Positive COVID19 patients of both sexes irrespective of age admitted
from 27 March 2020 and 26 April 2020 cases were included in the study. The final discharge date is taken as 5th May 2020.
Kaplan Meier survival analysis was adopted.

Results:
Male, female ratio were 141(56.2%): 83(33.1%), 12 (4.8%) Male Child and 15 (6.0%) were Female child. 5.2%
of the patients were in the age group greater than 60, 75.3% were in the age group 20-60, and the remaining 19.5% were 0-
20 age group. 84.9% of patients were Asymptomatic, while fever and cough were the main symptoms recorded in the
remaining cases. CT scan was done for 7 patients. No mortality and no serious adverse events were reported. Comorbidity
is 15% and does not influence hospital length of stay. The overall median length of stay is 12 days for those who were under
ZVcKK (Median ST CI- 11.59-12.41).

Conclusion:
This study recorded a median of 12 days in the Length of stay and 13.5 days in the Length of stay average.
Comparing earlier studies, patients taking ZVcKK have savings of 7 days. i.e., the relief speed is higher while using ZVcKK.
An Investigation of the Oil and Gas Geopolitical Situation in the Eastern
Mediterranean Region
Authors: Norouzi Nima 
Published: January 2021

:
One of the main global energy struggles in recent years has been in the Eastern Mediterranean.
In cooperation with Egypt and Israel, Greece and the Greek Cypriot government (GCA)
are implementing a containment strategy against Turkey and the Turkish Republic of Northern
Cyprus (TRNC). Turkey’s response to this plan was an exclusive agreement with Libya. Turkey
and Libya have signed a memorandum of national reconciliation on limiting the new continental
shelf’s maritime jurisdiction in the Eastern Mediterranean - the only borders of the shared economic
zone. Greece could act with other countries, and it is said that Turkey’s competence will be ratified
in the face of agreements that may restrict movement. The United States and the European
Union (EU) also sought to share gas with European countries against Turkey, Israel, and the GCA.
This article focuses on Libya’s ongoing competition, given Libya’s oil geopolitics and challenges
in the eastern Mediterranean region. This paper briefly investigates the energy geopolitics in the
eastern Mediterranean and North African regions; this paper aims to conclude the diverse opinions
led by various interests and points of view and suggests a solution for the ever-growing tensions in
this region.
Geogebra: Media Visualisasi Grafis untuk Penyusunan Bahan Ajar
Authors: Dhoruri Atmini , Lestari Dwi , Sari Eminugroho Ratna 
Published: January 2021

Menurut beberapa studi dan penelitian menunjukkan bahwa hasil belajar matematika siswa SMP di Indonesia dilihat dari kemampuan kognitif maupun afektif masih tergolong rendah. Kemampuan siswa berusia 15 tahun dalam membaca, matematika, dan sains, hasil yang dicapai siswa Indonesia jauh dari memuaskan. Untuk meningkatkan prestasi belajar siswa diperlukan langkah-langkah penyempurnaan secara mendasar dan konsisten serta sistematik dalam pembelajaran. Salah satu cara yang dilakukan untuk meningkatkan kualitas pembelajaran matematika adalah dengan memanfaatkan Geogebra untuk pembelajaran Matematika. Dua wilayah di Daerah Istimewa Yogyakarta yaitu Kabupaten Sleman dan Bantul masing-masing memiliki kelompok Musyawarah Guru Mata Pelajaran (MGMP) Matematika SMP. Kedua MGMP memiliki permasalahan yang hampir sama atau beririsan yaitu sebagian besar guru belum terampil dalam menyusun bahan ajar matematika dengan bantuan Geogebra. Selain itu kedua MGMP juga belum mengintegrasikan teknologi komputer dalam pembelajaran Matematika. Dalam prakteknya, guru menemui kesulitan untuk memvisualisasikan konsep materi persamaan garis (berupa grafik), kesebangunan, serta bangun datar dan bangun ruang. Pelatihan Geogebra sebagai solusi masalah tersebut, diberikan kepada guru matematika se MGMP Sleman dan Bantul. Pelatihan dilakukan sebanyak 3 pertemuan untuk masing-masing MGMP. Pada awal setiap pertemuan diberikan materi sementara peserta praktek, disetiap akhir pertemuan peserta diberi tugas untuk menyusun bahan ajar. Sebagai evaluasi pelaksanaan kegiatan diberikan angket evaluasi di akhir pertemuan. Berdasarkan angket, sebanyak 100% peserta sangat antusias mengikuti kegiatan workshop Geogebra ini. Di samping itu, sebesar 37.14% setuju dan 62.86% sangat setuju diadakan pelatihan Geogebra lanjutan. Sementara itu sebanyak 45.71% setuju dan 54.29 % sangat setuju materi workshop sesuai yang dibutuhkan dalam pembelajaran. Keberadaan asisten dirasa sangat membantu, hal ini tampak dari seluruh peserta menyatakan setuju atau sangat setuju. Dari hasil tugas peserta yang dikumpulkan tercatat nilai rata-rata lebih dari 85. Hal ini menunjukkan kemampuan guru menggunakan Geogebra dalam menyiapkan bahan ajar sangat baik.Kata Kunci : Geogebra, visualisasi, matematika
Understanding Gaps Between Daily Living and Clinical Settings in Chronic Disease Management: Qualitative Study
Authors: Ozkaynak Mustafa , Valdez Rupa , Hannah Katia , Woodhouse Gina , Klem Patrick 
Published: January 2021

BackgroundManagement of chronic conditions entails numerous activities in both clinical and daily living settings. Activities across these settings interact, creating a high potential for a gap to occur if there is an inconsistency or disconnect between controlled clinical settings and complex daily living environments.ObjectiveThe aim of this study is to characterize gaps (from the patient’s perspective) between health-related activities across home-based and clinical settings using anticoagulation treatment as an example. The causes, consequences, and mitigation strategies (reported by patients) were identified to understand these gaps. We conceptualized gaps as latent phenomena (ie, a break in continuity).MethodsPatients (n=39) and providers (n=4) from the anticoagulation clinic of an urban, western mountain health care system were recruited. Data were collected through primary interviews with patients, patient journaling with tablet computers, exit interviews with patients, and provider interviews. Data were analyzed qualitatively using a theory-driven approach and framework method of analysis.ResultsThe causes of gaps included clinician recommendations not fitting into patients’ daily routines, recommendations not fitting into patients’ living contexts, and information not transferred across settings. The consequences of these gaps included increased cognitive and physical workload on the patient, poor patient satisfaction, and compromised adherence to the therapy plan. We identified resources and strategies used to overcome these consequences as patient-generated strategies, routines, collaborative management, social environment, and tools and technologies.ConclusionsUnderstanding gaps, their consequences, and mitigating strategies can lead to the development of interventions that help narrow these gaps. Such interventions could take the form of collaborative health information technologies, novel patient and clinician education initiatives, and programs that strongly integrate health systems and community resources. Current technologies are insufficient to narrow the gaps between clinical and daily living settings due to the limited number and types of routines that are tracked.