bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on a system of nonlinear Schrödinger equations with potential and quadratic interaction
Authors: Alvarez Vicente , Esfahani Amin 
Published: February 2025

AbstractIn this work, we study the existence of various classes of standing waves for a nonlinear Schrödinger system with quadratic interaction, along with a harmonic or partially harmonic potential. We establish the existence of ground‐state normalized solutions for this system, which serve as local minimizers of the associated functionals. To address the difficulties raised by the potential term, we employ profile decomposition and concentration‐compactness principles. The absence of global energy minimizers in critical and supercritical cases leads us to focus on local energy minimizers. Positive results arise in scenarios of partial confinement, attributed to the spectral properties of the associated linear operators. Furthermore, we demonstrate the existence of a second normalized solution using the Mountain‐pass geometry, effectively navigating the difficulties posed by the nonlinear terms. We also explore the asymptotic behavior of local minimizers, revealing connections with unique eigenvectors of the linear operators. Additionally, we identify global and blow‐up solutions over time under specific conditions, contributing new insights into the dynamics of the system.
TDP‐43/ALKBH5‐mediated m6A modification of CDC25A mRNA promotes glioblastoma growth by facilitating G1/S cell cycle transition
Authors: Zhang Yunxiao , Xie Sidi , Li Weizhao , Gu Junwei , Zhang Xi‐an , Ni Bowen , Wang Ziyu , Yang Runwei , Song Haimin , Zhong Yaxuan , Huang Peiting , Zhou Jinyao , Cao Yongfu , Guo Jing , Liu Yawei , Qi Songtao , Wang Hai 
Published: February 2025

AbstractGlioblastoma (GBM) exhibits significant intratumor heterogeneity (ITH), indicating the presence of tumor cells with diverse growth rates. Here, we aimed to identify fast‐growing cells in GBM and elucidate the underlying mechanisms. Precisely targeting these cells could offer an improved treatment option. Our results found that targeting ALKBH5 expression impaired GBM proliferation and tumor stemness. Nuclear but not overall expression of ALKBH5 differs between monoclonal cells derived from the same patient with different proliferation rates. Mechanistically, ALKBH5 interacted with TAR DNA‐binding protein 43 (TDP‐43) in fast‐growing cells. Furthermore, TDP‐43 facilitated the nuclear localization of ALKBH5 and its binding to cell division cycle 25A (CDC25A) pre‐mRNA. The TDP‐43/ALKBH5 complex regulates CDC25A mRNA splicing via N6‐methyladenosine (m6A) demethylation to maintain the expression of its oncogenic isoform (CDC25A‐1), ultimately promoting the G1/S phase transition and growth of GBM cells. TRAD01 selectively targeted the interaction between TDP‐43 and ALKBH5, leading to significant antitumor effects both in vitro and in vivo. Our study identified a novel epigenetic mechanism by which TDP‐43/ALKBH5 contributes to GBM growth via m6A modification and alternative splicing. Therefore, targeting the TDP‐43/ALKBH5 axis might be a promising therapeutic strategy for GBM patients.
Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single‐Center Experience
Authors: Hvingelby Victor S. , Kjeldsen Pernille , Bergholt Bo , Schechtmann Gaston Andres , Danielsen Erik Hvid , Møller Mette , Johnsen Erik Lisbjerg , Mardosiene Skirmante , Lund Torben Ellegaard , Grauballe Dora , Geneser Michael , Sørensen Tina Vincens , Bak Lisa Østergaard , Andreasen Martin , Andersen Anne Sofie Møller , Andersen Lone , Meier Kaare , Juhl Niels , Tankisi Alp , Jespersen Bo , Eriksen Christian Fenger , Rasmussen Mads , Eriksen Winnie Bechmann , Barrutia Birgitte , Kromann Mette , Baandrup Ida , Bjørn Jette , Stjernholm Rie , Bræmer‐Madsen Charlotte , Jørgensen Signe Mygdal , Sørensen Jens Christian Hedemann , Glud Andreas Nørgaard 
Published: February 2025

AbstractBackgroundEssential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second‐line therapy.ObjectiveThe aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark.MethodsData were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician‐ and patient‐rated treatment efficacy was evaluated using the Fahn–Marin–Tolosa (FMT) scale and the Patient Global Impression of Change.ResultsA total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months.ConclusionOur findings are in line with existing evidence. Questions regarding persistence of gait‐ and balance‐related side effects remain.
Should Both Platforms Be Kept Operational After a Merger of Two Social Media Businesses?
Authors: Kanta Mishra Soumya , Sarkar Sumit , Guha Apratim 
Published: February 2025

ABSTRACTWhen two social media platform businesses merge, a critical decision for the merged entity is whether to keep both platforms operational. We investigate the role of user‐homing and the platforms' user bases and advertiser bases in the decision. The only source of revenue for the platforms is the fees charged to the advertisers for advertising on the platforms. Different groups of advertisers have different platform preferences. The main results show that when all users single‐home (multihome), the gain from the merger is more from keeping one (both) platform operational. A merger is welfare increasing if the users single‐home.
Functional Reconstruction of a Huge Lateral Thoraco‐Abdominal Defect With Combined Innervated Pedicled Latissimus Dorsi Flap and Vastus Lateralis Free Functional Muscle Transfer: A Case Report
Authors: Brunetti Beniamino , Morelli Coppola Marco , Oliveri Fiorella , Petrucci Valeria , Al‐Hilli Omar , Valeri Sergio , Alloni Rossana , Aprile Irene Giovanna , Tenna Stefania , Persichetti Paolo 
Published: February 2025

ABSTRACTFull thickness thoraco‐abdominal defects are traditionally challenging to reconstruct, exposing the patient to a significant risk of wound complications and functional impairment. The authors present an extremely challenging and unique case where a huge lateral thoraco‐abdominal defect was reconstructed with a combination of innervated flaps allowing to completely restore contour and function of the operated region. A 77‐year‐old male patient presented with a leiomyosarcoma arising in the right lateral thoraco‐abdominal region. Full‐thickness resection involved the anterior part of the latissimus dorsi (LD) and serratus anterior muscles along with IX to XII ribs, a cuff of diaphragm muscle and the entire lateral abdominal wall, creating a 30 × 25 cm defect with exposure of right lung, liver, and ascending and transverse colon. After the placement of a synthetic mesh, a 28 × 16 cm pedicled innervated LD flap was advanced in V‐Y fashion to cover the thoracic part of the defect. Then the patient was turned supine and a vastus lateralis free functional muscle transfer (FFMT) from the contralateral thigh was used to reconstruct the abdominal part of the defect. The recipient vessels were provided transposing the ipsilateral deep inferior epigastric pedicle according to the extra‐anatomical pedicle rerouting technique. Motor branch for the VL was coapted to a sizeable intercostal nerve. The muscle was covered with split‐thickness skin grafts. Both flaps healed uneventfully, allowing to obtain a complete restoration of form and function with M5 score according to the MRC Scale for muscle strength 8 months after surgery. Functional reconstruction of the lateral abdominal wall with FFMT has never been reported. Our successful case shows the importance of functional reconstruction of lateral thoraco‐abdominal defects to prevent abdominal weakness or herniation, trunk instability, postural deficiencies and core strength loss.
Low‐Cost and Highly‐Transparent Reflectarray Using On‐Glass Metal Line and ITO Grid Ground
Authors: Ren Jian , He Rui , Sun Yu‐Xiang , Wang Jiangang , Wang Yuexiang , Liu Jia , Zhang Hong‐Hao , Yin Yingzeng 
Published: February 2025

ABSTRACTIn this article, a transparent reflectarray (TRA) based on metal line, soda‐lime glass substrate, and grid ground, featuring low cost, high optical transparency (OT), and high efficiency, is investigated. The indium tin oxide (ITO) grid ground deposited on the soda‐lime glass substrate ensures high OT of the antenna while the metal line with a low square resistivity of 0.017 ohm/sq guarantees high efficiency. Two different element topologies are designed to enlarge the phase coverage and decrease the quantization error. The reflectarray element is implemented between 10.7 and 12.7 GHz, with a full phase coverage of 360° and a low reflection loss of 2.3 dB. Furthermore, low‐cost printed‐circuit‐board (PCB) processing techniques and magnetron sputtering deposition technology are used for manufacturing. To confirm the feasibility and effectiveness of the design, a 24 × 24‐element pencil‐beam reflectarray is fabricated and measured to verify the performance. The measured OT of the reflectarray is higher than 80% and the aperture efficiency reaches 42.5% at 11.2 GHz. Hence, the proposed TRA should be a potential candidate for window, vehicular, and display‐integrated wireless communications.
Broadband Circularly Polarized Metasurface Antenna Based on Characteristic Mode Analysis
Authors: Xu Juan , Pang Hui , Zhao Jianping , Fang Xiaohui 
Published: February 2025

ABSTRACTA broadband circularly polarized metasurface antenna is proposed. The initial metasurface structure is first diagonally chamfered and a rectangular slot is etched at the chamfer. The chamfering operation can cause an imbalance in the surface impedance of the hypersurface patch, and this imbalance creates a phase difference between the incident wave and the reflected wave, which is considered to be circularly polarized when the phase difference is close to 90° and the amplitudes of the two are equal. Analyze the metasurface structure after chamfering using the characteristic mode theory (CMT), further optimize it based on the obtained characteristic mode analysis results, and analyze it again using the characteristic mode. Finally, two target modes with a phase difference close to 90° were formed. The two characteristic modes are successfully excited by microstrip slot‐coupled feeding structure to achieve circularly polarized radiation of the antenna. Finally, the antenna is fabricated and measured. Based on the measured results, it can be observed that the antenna has 35.4% −10 dB impedance bandwidth, and 17% 3 dB axial ratio bandwidth, and the antenna simulated and measured results match.
Single‐Layer Dual‐Polarized Millimeter Wave Slot Antenna Using Nested Radiators Under Four Resonance Modes
Authors: Jiawang Li , Xiang Lei , Shi Yitong , Liu Huimin 
Published: February 2025

ABSTRACTThis letter proposes a novel single‐layer dual‐polarized (DP) millimeter wave (mmWave) low‐profile antenna. This antenna is based on a circular substrate integrated waveguide (SIW) resonant cavity. Two different resonant cavities are created by incorporating via fences internally: a conventional circular resonant cavity and a circular ring resonant cavity. The bandwidth is expanded by introducing a central via in the internal resonant cavity, which generates the TM010 and TM110 resonant modes. On the other hand, the external annular resonant cavity introduces the TM410 and TM510 resonant modes by carefully adjusting the size of the radiation slot. The radiation slots within the external annular resonant cavity and the inner circular resonant cavity are positioned orthogonally, enabling dual‐polarized (DP) operation. It is shown that the DP antenna can achieve the measured −10 dB impedance bandwidths (FBW) of 11.82% (26.26–29.56 GHz) and 11.15% (26.09–29.17 GHz) for port 1 and port 2, respectively. The antenna features stable radiation patterns with an average gain of 5.1 dBi and a high isolation exceeding 20 dB within the passband. The antenna exhibits a single‐layer structure, low profile, high‐isolation, and low‐cost advantages, which can be a good candidate for 5G mmWave indoor applications.
Dual‐Band Rectifier Dedicated to 2.45 and 5.8 GHz Bands for Radiofrequency Energy Harvesting
Authors: Assogba Ognadon , Mbodji Abdoul Karim , Farota Abdou Karim , Diallo Abdou Karim , Bréard Arnaud , Duroc Yvan 
Published: February 2025

ABSTRACTThis paper presents the design of a high‐performance rectifier for radiofrequency energy harvesting (RF‐EH) system. The proposed prototype operates in the two frequency bands, 2.45 and 5.8 GHz (part of the radio spectrum reserved internationally for industrial, scientific, and medical [ISM] purposes), which are widely present in the ambient environment, and enables energy to be recovered at low power levels to power loads of widely varying impedances. The designed rectifier is manufactured with dimensions of 0.31 × 0.17, with the wavelength corresponding to the 2.45 GHz frequency. The rectifier is dual‐band with a single series topology and good performance in terms of conversion efficiency at very low power levels (18% at −20 dBm at 2.45 GHz and 14% at −10 dBm at 5.8 GHz). The design methodology is detailed, and experimental results based on the prototype are presented and compared with the literature.
Wideband Tapered Rod MIMO Antenna for W‐Band Applications
Authors: Baranwal Arpit Kumar , Mohan Akhilesh , Pathak Nagendra P. 
Published: February 2025

ABSTRACTIn this paper, a wide band tapered rod two‐element MIMO antenna system is designed using a perforated H‐guide section for W‐band applications. The antenna system comprises of a metallic housing and a perforated H‐guide section with tapered input/output dielectric sections. The dielectric section is sandwiched between the two halves of the metallic housing. The designed MIMO antenna is fed by a pair of WR‐10 rectangular waveguides. The perforations in the dielectric section not only provide the mechanical stability to the structure but also facilitate high inter‐port isolation. The MIMO performance of the designed antenna system is calculated with reference to envelope correlation coefficient (ECC), diversity gain (DG), and channel capacity loss (CCL). These parameters are below the satisfactory range of 0.5, 10 dB, and 0.4 bit/s/Hz. High gain (> 12 dBi), high port‐to‐port isolation (> 28 dB), and end‐fire radiation characteristics of the designed antenna system, make it a potential candidate for W‐band communication systems.
Solid‐State NMR‐Assisted Dynamic Characterization of two Isostructural Solvates of 5α‐Bromo‐6β,19‐Epoxy‐Androstan‐3β,17β‐Diol Diacetate
Authors: Vazquez‐Chavez Josué , Navarro‐Huerta Armando , Flores‐Álamo Marcos , Rodríguez‐Molina Braulio , Iglesias‐Arteaga Martín A. 
Published: February 2025

AbstractThe study reports on the rotational dynamics of acetone‐d6 (Form II) and DMSO‐d6 (Form III) within the crystalline structures of two solvates of 5α‐bromo‐6β,19‐epoxy‐androstan‐3β,17β‐diol diacetate (Compound 1) by means of solid‐state Nuclear Magnetic Resonance through the quadrupolar 2H spin‐echo technique. The spectral data allowed the determination of the activation barriers (Ea) for rotation of the solvent molecules, with 6.24 kcal mol−1 for deuterated acetone in the Form II‐d6 and 8.19 kcal mol−1 for the case of deuterated dimethylsulfoxide in Form III‐d6. The use of calculations and the Transition State theory through the linear Eyring equation suggested that although the acetone molecules experience a low activation energy (Ea = 6.24 kcal mol−1), a highly ordered transition state during the molecular motion reduces its rotational rate. Conversely, the DMSO molecules, with a higher activation barrier (Ea = 8.19 kcal mol−1) attributed to a denser packing coefficient, have faster motional rates. Based on complementary X‐ray and NMR spectroscopy techniques, this work provides detailed insights into the mechanistic phenomena involved in the mobility of small molecules inside crystalline arrangements.
Myotonic Dystrophy (DM) Burden of Disease: A Retrospective Study of Healthcare Costs and Utilization by Individuals With DM
Authors: Martinez‐Thompson Jennifer M. , Tobin W. Oliver , Dykhoff Hayley J. , Sangaralingham Lindsey R. , White Molly K. , Selcen Duygu , Borah Bijan J. 
Published: February 2025

ABSTRACTIntroduction/AimsHealthcare utilization and costs in myotonic dystrophy (DM) are not well understood. This study describes the burden of DM and its associated costs.MethodsWe performed a retrospective study using data from a large U.S. administrative claims database to identify commercially insured individuals with DM and compared healthcare utilization and cost with a matched cohort. Analyses were performed between the cohorts with ≥ 3 years of insured follow‐up.ResultsWe identified 1182 DM individuals with coverage at least 3 year prior and 3 years following an index DM diagnosis from January 1, 2009 to December 31, 2018. Compared to controls, DM individuals were 3.7 times more likely to be hospitalized (p < 0.0001), 2.4 times more likely to visit an emergency department (p < 0.0001), and had twice as many outpatient visits (p < 0.0001) in the first year post‐diagnosis, with similar utilization at 2‐ and 3‐years post‐diagnosis. Annual mean costs were 3.9 times higher for health plan paid costs (p < 0.0001) and 2.6 times higher for patient‐paid costs (p < 0.0001) for DM individuals than controls in the first year post‐diagnosis, with similar costs at 2‐ and 3‐years post‐diagnosis. Factors associated with higher costs included the need for durable medical equipment, including gait aids or respiratory support devices.DiscussionIndividuals with DM experience significantly higher healthcare utilization and associated healthcare costs than controls of similar age, sex, race, and census region. The findings show the high clinical and economic burden of DM, highlighting the importance of improving cost‐effective care delivery in this population.
Mechanical Behaviors of Rigid Pile Composite Foundation in Yellow River Alluvial Plain Subjected to Soil Water Content Variations
Authors: Liu Yunlong , Xia Yanyan , Zhang Jingwei , Uge Bantayehu Uba 
Published: February 2025

ABSTRACTRigid pile composite foundation (RPCF) has been widely used in Yellow River Alluvial Plain (YRAP) due to remarkable reinforcement and economical effects. However, current design of RPCF in this area are typically based on saturated soil mechanic principles assuming drained condition, despite the fact that the soil is typically in unsaturated condition. Due to long time water scouring, the silt in YRAP generally exhibits high particle sphericity and poor particle gradation. Even after standard compaction, it is still in a relatively loose state with developed capillary pores. Water content increment induced by infiltration can lead to considerable soil mechanical properties degradations due to matric suction reduction associated with soil micro‐structure rearrangement. Consequently, the RPCF will suffer serious bearing characteristic deteriorations, exhibiting additional settlement. In this study, extending unsaturated soil mechanics, initially the influences of matric suction on mechanical properties of YRAP silt were demonstrated. Then total RPCF settlement was calculated as the sum of the compression deformation of the soil between piles in the reinforcement zone and the underlying soil stratum. The former one was estimated through the modified load transfer curve method considering the pile‐soil interface behaviors deteriorations with matric suction reduction, while the later one was estimated through the traditional stress diffusion method. The feasibility of the proposed method was validated through a model RPCF test subjected to ground water level fluctuations. Good comparisons on RPCF mechanical behaviors indicate the proposed method can be a valuable tool in the design of RPCF in YRAP under extreme weather conditions.
Distinct spatial N‐glycan profiles reveal glioblastoma‐specific signatures
Authors: Angerstein Aaron O. , Young Lyndsay E.A. , Thanasupawat Thatchawan , Vriend Jerry , Grimsley Grace , Lun Xueqing , Senger Donna L. , Sinha Namita , Beiko Jason , Pitz Marshall , Hombach‐Klonisch Sabine , Drake Richard R. , Klonisch Thomas 
Published: February 2025

AbstractThis study explored the complex interactions between glycosylation patterns, tumour biology, and therapeutic responses to temozolomide (TMZ) in human malignant glioma, specifically CNS WHO grade 3 oligodendroglioma (ODG) and glioblastoma (GB). Using spatial imaging of N‐glycans in formalin‐fixed paraffin‐embedded (FFPE) tissue sections via MALDI‐MSI, we analysed the N‐glycome in primary and recurrent GB tissues and orthotopic xenografts of patient‐derived brain tumour‐initiating cells (BTIC) sensitive or resistant to TMZ. We identified unique N‐glycosylation profiles, with nontumor brain (NTB) and ODG showing higher levels of bisecting and tri‐antennary structures, while GB exhibited more tetra‐antennary and sialylated N‐glycans. Distinctive sialylation patterns were observed, with specific α2,6 and α2,3 isomeric linkages significantly altered in GB. Moreover, comparative analysis of primary and recurrent GB tissues revealed elevated high mannose N‐glycans in primary GB and fucosylated bi‐ and tri‐antennary N‐glycans in recurrent GB tissues. Next, in the orthotopic xenografts of TMZ‐sensitive and TMZ‐resistant patient brain tumour initiating cells (BTIC), we identified potential N‐glycan markers for TMZ treatment response and resistance. Finally, we found significantly altered expression of genes involved in N‐glycan biosynthesis in malignant glioma, highlighting the crucial role of N‐glycans in glioma and therapy resistance. This study lays the foundation for developing glycosylation‐based diagnostic biomarkers and targeted therapies, potentially improving clinical outcomes for GB patients. © 2025 The Pathological Society of Great Britain and Ireland.