bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brand bullying: from stressing to expressing
Authors: Kucuk S. Umit , Aledin Samil A. 
Published: November 2021

Purpose
This study aims to investigate a neglected phenomenon, conceptualized as “brand-bullying.” The study aims at defining the brand bullying phenomena with adolescents who are actively experiencing brand bullying. Potential impacts of brand bullying experience on adult consumption behaviors are also investigated.

Design/methodology/approach
This paper provides a literature review of brand bullying and uses two qualitative analyses with adolescent and adult consumers through face-to-face interviews.

Findings
Study-1 found five different styles of brand bullying behavior with adolescents. Study-2’s findings revealed four distinct styles of brand bullying coping behaviors in adulthood. Study-2 also found that brand-bullying’s negative effects could continue after the bullying process is long over and has the potential to cause consumer brand hate (in the form of brand avoidance and disgust) and can cause conspicuous consumption patterns in adulthood in the future. The study further reports that neither the economically unfortunate nor the wealthy are immune to brand bullying.

Originality/value
This is the first study to investigate the brand bullying concept and its expression among adolescents, as well as its impact on adult consumption behaviors. The study is among the first to report the negative impact of brand bullying on adult consumer behaviors and consumption patterns in adulthood from a consumer psychology perspective.
The role of emerging technologies in implementing green practices to achieve sustainable operations
Authors: Umar Muhammad , Khan Syed Abdul Rehman , Zia-ul-haq Hafiz Muhammad , Yusliza Mohd Yusoff , Farooq Khalid 
Published: November 2021

PurposeThe current study investigates the effect of industry 4.0 on green practices, including green manufacturing and green logistics, in the context of emerging economies.Design/methodology/approachA cross-sectional data were collected from 234 manufacturing firms in Pakistan, and PLS-SEM was employed to test hypotheses.FindingsWith the advent of industry 4.0 in the current era, more emphasis is being given to the adoption of digital technologies in every field. The adoption of the green approach in supply chain management provides firms with socioeconomic and environmental benefits. The study results indicate that industry 4.0 positively affects green practices, including green manufacturing and green logistics. Moreover, the results also illustrate that these green practices have a substantial effect on the sustainability performance of the firms.Research limitations/implicationsThis study provides an amplified understanding of the industry 4.0 technologies in the adoption of green practices. The outcomes also offer a policy framework for managers, legislators and manufacturers to promote green practices (i.e. green manufacturing and green logistics) in businesses.Originality/valueAlthough several recent studies have tried to investigate the effect of green practices on sustainability performance. However, as per the author's best knowledge, very few studies have analyzed the influence of industry 4.0 on green practices (i.e. green manufacturing and green logistics) in the context of emerging economies.
Age‐dependent timing and routes demonstrate developmental plasticity in a long‐distance migratory bird
Authors: Verhoeven Mo A. , Loonstra A. H. Jelle , McBride Alice D. , Kaspersma Wiebe , Hooijmeijer Jos C. E. W. , Both Christiaan , Senner Nathan R. , Piersma Theunis 
Published: November 2021

Abstract

Longitudinal tracking studies have revealed consistent differences in the migration patterns of individuals from the same populations. The sources or processes causing this individual variation are largely unresolved. As a result, it is mostly unknown how much, how fast and when animals can adjust their migrations to changing environments.

We studied the ontogeny of migration in a long‐distance migratory shorebird, the black‐tailed godwit Limosa limosa limosa, a species known to exhibit marked individuality in the migratory routines of adults. By observing how and when these individual differences arise, we aimed to elucidate whether individual differences in migratory behaviour are inherited or emerge as a result of developmental plasticity.

We simultaneously tracked juvenile and adult godwits from the same breeding area on their south‐ and northward migrations. To determine how and when individual differences begin to arise, we related juvenile migration routes, timing and mortality rates to hatch date and hatch year. Then, we compared adult and juvenile migration patterns to identify potential age‐dependent differences.

In juveniles, the timing of their first southward departure was related to hatch date. However, their subsequent migration routes, orientation, destination, migratory duration and likelihood of mortality were unrelated to the year or timing of migration, or their sex. Juveniles left the Netherlands after all tracked adults. They then flew non‐stop to West Africa more often and incurred higher mortality rates than adults. Some juveniles also took routes and visited stopover sites far outside the well‐documented adult migratory corridor. Such juveniles, however, were not more likely to die.

We found that juveniles exhibited different migratory patterns than adults, but no evidence that these behaviours are under natural selection. We thus eliminate the possibility that the individual differences observed among adult godwits are present at hatch or during their first migration. This adds to the mounting evidence that animals possess the developmental plasticity to change their migration later in life in response to environmental conditions as those conditions are experienced.
Modelling management strategies for chronic disease in wildlife: Predictions for the control of respiratory disease in bighorn sheep
Authors: Almberg Emily S. , Manlove Kezia R. , Cassirer E. Frances , Ramsey Jennifer , Carson Keri , Gude Justin , Plowright Raina K. 
Published: November 2021

Abstract

Controlling persistent infectious disease in wildlife populations is an ongoing challenge for wildlife managers and conservationists worldwide, and chronic diseases in particular remain a pernicious problem.

Here, we develop a dynamic pathogen transmission model capturing key features of Mycoplasma ovipneumoniae infection, a major cause of population declines in North American bighorn sheep Ovis canadensis. We explore the effects of model assumptions and parameter values on disease dynamics, including density‐ versus frequency‐dependent transmission, the inclusion of a carrier class versus a longer infectious period, host survival rates, disease‐induced mortality and recovery rates and the epidemic growth rate. Along the way, we estimate the basic reproductive ratio, R0, for M. ovipneumoniae in bighorn sheep to fall between approximately 1.36 and 1.74.

We apply the model to compare efficacies across a suite of management actions following an epidemic, including test‐and‐remove, depopulation‐and‐reintroduction, range expansion, herd augmentation and density reduction.

Our results suggest that test‐and‐remove, depopulation‐and‐reintroduction and range expansion could help persistently infected bighorn sheep herds recovery following an epidemic. By contrast, augmentation could lead to worse outcomes than those expected in the absence of management. Other management actions that improve host survival or reduce disease‐induced mortality are also likely to improve population size and persistence of chronically infected herds.

Synthesis and applications. Dynamic transmission models like the one employed here offer a structured, logical approach for exploring hypotheses, planning field experiments and designing adaptive management. We find that management strategies that removed infected animals or isolated them within a structured metapopulation were most successful at facilitating herd recovery from a low‐prevalence, chronic pathogen. Ideally, models like ours should operate iteratively with field experiments to triangulate on better approaches for managing wildlife diseases.
Quantitative evaluation of the Achilles tendon and supraspinatus tendon in end‐stage kidney disease patients: A potential tool for predicting spontaneous tendon rupture
Authors: Tang Xinyi , Wang Jing , Guo Ruiqian , Huang Songya , Qiu Li 
Published: November 2021

AbstractMany cases of spontaneous tendon rupture in end‐stage kidney disease (ESKD) patients have been reported worldwide. Quantitative assessment of tendon has become an important way to improve the prognosis of patients. In the recruited healthy volunteers and ESKD patients, the thickness and shear wave velocity (SWV) of supraspinatus tendons and Achilles tendons were measured and compared among groups. Potential factors related to the tendon SWV of ESKD patients were screened in multiple linear regression. There was no significant difference in the tendon thickness and supraspinatus tendon SWV among groups. SWV of Achilles tendons in long‐term dialysis ESKD patients were significantly lower than those in healthy volunteers (5.1 vs. 5.6 m/s, p < 0.01). Ca2+, creatinine, body mass index, and genders are the significant factors related to the tendon SWV. Shear wave elastography can be used as a potential tool for predicting spontaneous tendon rupture in ESKD patients.
Minimally invasive treatments for benign prostatic hyperplasia: a Cochrane network meta‐analysis
Authors: Franco Juan Victor Ariel , Jung Jae Hung , Imamura Mari , Borofsky Michael , Omar Muhammad Imran , Escobar Liquitay Camila Micaela , Young Shamar , Golzarian Jafar , Veroniki Areti Angeliki , Garegnani Luis , Dahm Philipp 
Published: November 2021

ObjectiveTo assess the comparative effectiveness and ranking of minimally invasive treatments (MITs) for lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH).Materials and MethodsWe searched multiple databases up to 24 February 2021. We included randomized controlled trials assessing the following treatments: convective radiofrequency water vapour thermal therapy (WVTT; or Rezūm); prostatic arterial embolization (PAE); prostatic urethral lift (PUL; or Urolift); temporary implantable nitinol device (TIND); and transurethral microwave thermotherapy (TUMT) compared to transurethral resection of the prostate (TURP) or sham surgery. We performed a frequentist network meta‐analysis.ResultsWe included 27 trials involving 3017 men. The overall certainty of the evidence of most outcomes according to GRADE was low to very low. Compared to TURP, we found that PUL and PAE may result in little to no difference in urological symptoms, while WVTT, TUMT and TIND may result in worse urological symptoms. MITs may result in little to no difference in quality of life, compared to TURP. MITs may result in a large reduction in major adverse events compared to TURP. We were uncertain about the effects of PAE and PUL on retreatment compared to TURP, however, TUMT may result in higher retreatment rates. We were very uncertain of the effects of MITs on erectile function and ejaculatory function. Among MITs, PUL and PAE had the highest likelihood of being the most efficacious for urinary symptoms and quality of life, TUMT for major adverse events, WVTT and TIND for erectile function and PUL for ejaculatory function. Excluding WVTT and TIND, for which there were only studies with short‐term (3‐month) follow‐up, PUL had the highest likelihood of being the most efficacious for retreatment.ConclusionsMinimally invasive treatments may result in similar or worse effects concerning urinary symptoms and quality of life compared to TURP at short‐term follow‐up.
Endothelial TRPV4–eNOS coupling as a vital therapy target for treatment of hypertension
Authors: Mao Aiqin , Zhang Peng , Zhang Ka , Kan Hao , He Dongxu , Han Xiping , Wang Zhiwei , Tang Chunlei , Ma Xin 
Published: November 2021

Background and PurposeReduced NO levels and activity are signs of endothelial dysfunction, which is important in mediating BP changes. Previously, we demonstrated that transient receptor potential channel V4 (TRPV4) could form a functional complex with other proteins to mediate vasodilation in endothelial cells (ECs). But how TRPV4 interacts with the NO pathway in larger arteries requires further exploration.Experimental ApproachWe used single‐cell RNA‐sequencing to find the CD106+ TRPV4highNOS3high ECs. The TRPV4–eNOS interaction was verified by co‐immunoprecipitation and immuno‐FRET, and their binding site was found by site‐directed mutagenesis. Endothelium‐specific TRPV4 knockout (TRPV4EC−/−) mice were used to study the effect of the TRPV4–eNOS interaction on BP. A small molecule, JNc‐463, was designed through molecular docking technology.Key ResultsWe uncovered CD106+ TRPV4highNOS3high ECs in the mouse aorta, which could regulate vasodilation via a TRPV4–eNOS interaction, and were essential to regulate BP. The TRPV4–eNOS interaction markedly decreased during the process of hypertension. We further attempted to identify molecules involved in the TRPV4–eNOS interaction and developed a small‐molecule drug, JNc‐463, which could increase the TRPV4–eNOS interaction to enhance vasodilation and exert antihypertensive effects in mice.Conclusion and ImplicationsThis is the first study integrating single‐cell RNA‐Seq, single‐cell functional study and drug screening in aorta. We identified a subpopulation of CD106+ TRPV4highNOS3high ECs, in which an impaired TRPV4–eNOS interaction was important in the progress of hypertension, and we designed a small molecule, JNc‐463, to improve the impaired TRPV4–eNOS interaction in hypertension.
A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody‐antigen system
Authors: Wu Jinyu , Wang Peng , Han Zhuo , Li Tiandong , Yi Chuncheng , Qiu Cuipeng , Yang Qian , Sun Guiying , Dai Liping , Shi Jianxiang , Wang Keyan , Ye Hua 
Published: November 2021

AbstractHepatocellular carcinoma (HCC) is a malignancy with a dismal survival rate. The novel autoantibodies panel may provide new insights for the diagnosis of HCC. Biomarkers screened by two methods (bioinformatics and the antigen‐antibody system) were taken as candidate tumor‐associated antigens (TAAs). Enzyme‐linked immunosorbent assay was used to detect the corresponding autoantibodies in 888 samples of verification and validation cohorts. The verification cohort was used to verify the autoantibodies. Samples in the validation cohort were randomly divided into a train set and a test set with the ratio of 6:4. A diagnostic model was established by support vector machines within the train set. The test set further verified the model. Eleven TAAs were selected (AAGAB, C17orf75, CDC37L1, DUSP6, EID3, PDIA2, RGS20, PCNA, TAF7L, TBC1D13, and ZIC2). The titer of six autoantibodies (PCNA, AAGAB, CDC37L1, TAF7L, DUSP6, and ZIC2) had a significant difference in any of the pairwise comparisons among the HCC, liver cirrhosis, and normal control groups. The titer of these autoantibodies had an increasing tendency. Finally, an optimum diagnostic model was constructed with the six autoantibodies. The AUCs were 0.826 in the train set and 0.773 in the test set. The area under the curve (AUC) of this panel for diagnosing early HCC was 0.889. The diagnostic ability of the panel reduced with the progress of HCC. The positive rate of the panel in diagnosing alpha‐fetoprotein (AFP)‐negative patients was 75.6%. For early HCC, the sensitivity of the combination of AFP with the panel was 90.9% and superior to 53.2% of AFP alone. The novel immunodiagnosis panel combining AFP may be a new approach for the diagnosis of HCC, especially for early‐HCC cases.
Real‐world experience with the Sydney System on 1458 cases of lymph node fine needle aspiration cytology
Authors: Caputo Alessandro , Ciliberti Valeria , D'Antonio Antonio , D'Ardia Angela , Fumo Rosalba , Giudice Valentina , Pezzullo Luca , Sabbatino Francesco , Zeppa Pio 
Published: November 2021

AbstractIntroductionLymph node (LN) fine needle aspiration cytology (FNAC) is a safe, quick, inexpensive, reliable, and minimally invasive technique for the diagnosis of lymphadenopathies. Recently, an international committee of experts proposed guidelines for the performance, classification, and reporting of LN‐FNAC: the Sydney System. We set out to analyse the diagnostic performance of the Sydney System in a retrospective study.MethodsWe retrieved 1458 LN‐FNACs, reformulated the diagnoses according to the Sydney System, and compared them to the histological control where available (n = 551, 37.8%).ResultsThe risk of malignancy for each of the five categories was 66.7% for inadequate/insufficient, 9.38% for benign (overall: 0.84%), 28.6% for atypical, 100% for suspicious and 99.8% for malignant. LN‐FNAC showed a sensitivity of 97.94%, a specificity of 96.92%, a positive predictive value of 99.58%, and a negative predictive value of 86.30%.ConclusionsThese data support the usage of LN‐FNAC as an agile first‐level technique in the diagnosis of lymphadenopathies. The Sydney System supports and enhances this role of LN‐FNAC, and its adoption is encouraged. In negative cases, coupled with ancillary techniques, LN‐FNAC can reassure the clinician regarding the benignity of a lymphadenopathy and indicate the need for clinical follow‐up, which will catch possible false negatives. In positive cases, LN‐FNAC can provide sufficient information, including predictive biomarkers, to initiate management and obviate the need for subsequent, more invasive procedures. Given its speed, minimal invasiveness, and low cost, LN‐FNAC can be performed in most cases, even when more invasive techniques are not feasible.
Psychological morbidity in pemphigus patients in clinical remission and its relation with clinico‐demographic parameters
Authors: De Dipankar , Kumar Sheetanshu , Handa Sanjeev , Mahajan Rahul , Singh Shubh Mohan 
Published: November 2021

SummaryBackground and objectivesSignificant psychological morbidity exists in patients with active pemphigus. Pemphigus being a chronic disease, psychological morbidity may exist in pemphigus patients in remission as well. The objectives of the study were to assess the psychological morbidity in pemphigus patients in clinical remission and to correlate it with clinico‐demographic parameters.Patients and methodsPemphigus patients in clinical remission were consecutively included and were asked to respond to the Hindi/English version of Patient Health Questionnaire (PHQ‐9), Generalized Anxiety Disorder (GAD‐7) and panic disorder module of PHQ.ResultsOf 107 patients recruited, 41 (38.3 %, 95 % CI: 29.1–48.2 %) patients were found to have either depression (33 [30.8 %, 95 % CI: 22.2–40.5 %]) or anxiety (38 [35.5 %, 95 % CI: 26.5–45.4 %] syndrome based on cut‐offs of PHQ‐9 score and GAD‐7 score, respectively. Number of patients with mild, moderate and moderately severe/severe depression syndrome were 26 (24.3 %, 95 % CI: 17.2–33.2 %), 7 (6.5 %, 95 % CI: 0.3–12.9 %) and 0 respectively and patients with mild, moderate, severe anxiety syndrome were 29 (27.1 %, 95 % CI: 19.6–36.2 %), 9 (8.4 %, 95 % CI: 4.5–15.2 %) and 0 respectively. Patients with anxiety or depression syndrome had significantly higher clinical disease activity in the past, number of days spent in dermatology inpatient and significantly shorter clinical remission at the time of assessment as compared to those without these symptoms.ConclusionsSignificant burden of mild/moderate depression or anxiety syndrome associated with past severity of disease and shorter duration of clinical remission was found.
The role of social signals in segmenting observed actions in 18‐month‐old children
Authors: Kliesch Christian , Parise Eugenio , Reid Vincent , Hoehl Stefanie 
Published: November 2021

AbstractLearning about actions requires children to identify the boundaries of an action and its units. Whereas some action units are easily identified, parents can support children's action learning by adjusting the presentation and using social signals. However, currently, little is understood regarding how children use these signals to learn actions.In the current study, we investigate the possibility that communicative signals are a particularly suitable cue for segmenting events. We investigated this hypothesis by presenting 18‐month‐old children (N = 60) with short action sequences consisting of toy animals either hopping or sliding across a board into a house, but interrupting this two‐step sequence either (a) using an ostensive signal as a segmentation cue, (b) using a non‐ostensive segmentation cue and (c) without additional segmentation information between the actions.Marking the boundary using communicative signals increased children's imitation of the less salient sliding action. Imitation of the hopping action remained unaffected. Crucially, marking the boundary of both actions using a non‐communicative control condition did not increase imitation of either action. Communicative signals might be particularly suitable in segmenting non‐salient actions that would otherwise be perceived as part of another action or as non‐intentional. These results provide evidence of the importance of ostensive signals at event boundaries in scaffolding children's learning.
Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus
Authors: Sen Souvik , An Hongyu , Sollman Myriam , Oakes Jonathan , Eron Joseph , Robertson Kevin , Powers William 
Published: November 2021

AbstractBackground and purposeRegional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) in whole brain, white matter, gray matter and lenticular nuclei were studied in people living with human immunodeficiency virus (PLHIV) as well as HIV‐associated neurocognitive disorder (HAND).MethodsTreatment‐naïve PLHIV underwent neurocognitive assessment and magnetic resonance (MR) measurement of rCBF and rCMRO2 with repeat after 12 months of antiretroviral therapy (ART). Age‐ and sex‐matched controls underwent single MR measurements. Regional CBF and rCMRO2 were compared amongst symptomatic, asymptomatic, normal HAND and controls using analysis of variance. Longitudinal analysis of HAND worsening (≥1 category) was assessed after 12 months of ART and correlated with rCBF and rCMRO2 measured by MR imaging using the paired‐sample t test.ResultsThirty PLHIV completed baseline and 12‐month assessments (29 with rCMRO2 measurement). At baseline HAND assessment, 13% had no cognitive impairment, 27% had asymptomatic neurocognitive impairment, 60% had mild neurocognitive disorder and none had HIV‐associated dementia. At 12 months, 13% had no cognitive impairment, 20% had asymptomatic neurocognitive impairment, 50% had mild neurocognitive disorder and 17% had HIV‐associated dementia. In those without HAND worsening (N = 21) rCMRO2 remained stable and in those with HAND worsening (N = 8) rCMRO2 measurement declined from baseline to 12 months in white matter (2.05 ± 0.40 to 1.73 ± 0.51, p = 0.03) and lenticular nuclei (4.32 ± 0.39 to 4.00 ± 0.51, p = 0.05).ConclusionsIn recently diagnosed PLHIV, no association was found between rCBF or rCMRO2 and cognitive impairment at baseline. There was a reduction in rCMRO2 in those with worsening of cognitive function at 12 months on ART. Reduction in rCMRO2 may be a biomarker of cognitive decline in PLHIV.