bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal dynamic and regional differences of public attention to vaccination: An empirical study in China
Authors: Zhang Yaming , Guo Xiaoyu , Su Yanyuan 
Published: December 2024

Background
Internet searches offer an indicator of public attention and possible demand for certain things. Studying the spatiotemporal characteristics of the public’s concern for vaccination can determine the spatiotemporal distribution of demand for vaccines in China, and capture the changes in the health awareness of the Chinese population, thus informing future vaccination strategies.

Methods
Based on the collection of Baidu search indices for vaccination-related keywords in 363 cities in China, This paper seeks to explore the spatiotemporal changes and regional differences in public attention toward vaccination in China by using the seasonal index, seasonal concentration index, Herfindahl index, Moran index, and Dagum Gini coefficient.

Results
The following findings are presented. First, there are significant seasonal fluctuations and unbalanced monthly distributions of vaccination-related public attention in China. Second, the public attention in Chinese cities shows the spatial characteristics of "leading in the east, followed by the central, western and northeastern regions". The spatial correlation of attention has been strengthened, and the high-high clusters are mainly distributed in the Beijing-Tianjin-Hebei (BTH), Yangtze River Delta (YRD), and Greater Bay Area (GBA) urban agglomerations. Third, regional differences in overall public attention narrowed in China, with intra-regional differences narrowing in seven regions (Northwest China, Central China, and so on), and intra-regional differences increasing in East China. The dominant role in the Gini coefficient changes from transvariation intensity to inter-regional differences.

Conclusion
Major public health emergencies stimulate the public’s attention to health topics. Although the short-term increase in vaccination-related public attention was not observed to translate into a long-term increase in public vaccine literacy, the seasonal and regional differences in vaccination-related public attention in China have significantly narrowed before and after COVID-19, suggesting that the imbalance between public health literacy levels has improved.
Identifying potential drug targets for myocardial infarction through Mendelian randomization
Authors: Yu Xiangyou , Liu Shasha 
Published: December 2024

Background
This study explored the associations between plasma and cerebrospinal fluid (CSF) proteins and myocardial infarction (MI) risk. Identifying specific proteins as biomarkers for MI could enhance our understanding of disease mechanisms and inform clinical practice.

Methods
We combined protein quantitative trait loci (pQTL) data for plasma and CSF proteins with genome-wide association study (GWAS) summary statistics for MI. Mendelian Randomization (MR) analyses were conducted to establish causal relationships, supported by Bayesian colocalization and Spearman correlation analyses. For plasma proteins, we used pQTL data from Cheng et al. to select 738 cis-acting SNPs associated with 734 proteins. The "TwoSampleMR" method and inverse-variance weighted MR were applied for evaluations.

Results
In plasma, CD8A and HDHD2 were identified as protective factors against MI, while DPEP1 was linked to increased risk. In CSF, CD30 Ligand was associated with MI risk. Bayesian colocalization supported the association for CD8A in plasma. No significant correlation was found between plasma and CSF results, suggesting distinct mechanisms for these biomarkers.

Conclusion
Our study identified several plasma and CSF proteins linked to MI risk, offering new insights into the disease’s biological underpinnings. These findings could guide future research on MI biomarkers and contribute to improved prevention and treatment strategies.
Health-related quality of life in a large cohort of patients with cardiac implantable electronic devices A registry-based study
Authors: Gatti Paolo , Nymark Carolin , Gadler Fredrik 
Published: December 2024

Aim
The association of cardiac implantable electronic devices (CIED), namely pacemaker (PM), implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy with (CRT-D) or without defibrillator (CRT-P) with health-related quality of life (HRQoL) is lacking.

Methods and results
Data from the Swedish Pacemaker and ICD Registry collected from January 2019 to February 2022 was used to analyze the responses to the European Quality of Life-5 Dimension questionnaire (EQ-5D) before and after one year of the CIED implant. Descriptive analysis was performed using Pearson’s chi-square test, the analysis of variance ANOVA, the Kruskal-Wallis test and Wilcoxon signed-rank test when appropriate. A multivariable regression analysis was used to compare the EQ-5D index and EQ-VAS variation after 1 year. Of 1,479 who completed the EQ-5D, 80% had a PM, 10% an ICD, 5% a CRT-P and 6% a CRT-D. The median age was 77 years with females constituting 38% of the PM group and 17% of the ICD group. The EQ-VAS and the EQ-5D index significantly increased after one year from the PM and CRT-P implant (EQ-VAS +2.8, standard deviations (SD) 23 and +5.8, SD 24.9; EQ-5D index +0.019, SD 0.114 and +0.051, SD 0.125) while only the EQ-5D index increased after one year from the ICD implant (+0.002, SD 0.104). After adjusting for age, sex and HRQoL at baseline, the presence of defibrillator was associated with lower EQ-VAS (ICD EQ-VAS variation: -3.4, 95% confidence intervals (CI) -6.7; -0.1 and CRT-D EQ-VAS variation -4.8, 95% CI -8.8;-0.7) and EQ-5D index (ICD EQ-5D index variation: -0.018, 95% CI -0.035; -0.0003 and CRT-D EQ-5D index variation -0.025 95% CI 0.046;0.004) after one year compared to PM.

Conclusion
These findings, showing the HRQoL associated with CIED, are important to support physicians’ and pacemaker nurses’ care after device implantation by embracing the patients’ perspectives.
Left ventricle remodeling by CMR in treated patients with primary aldosteronism and primary systemic arterial hypertension
Authors: Reiser Carolina S. , Assuncao Antonildes N. , Araujo-Filho Jose A. B. , Dantas Roberto N. , Bortolotto Luiz A. , Parga-Filho Jose R. 
Published: December 2024

Background
Increased cardiac after load and multiple non-hemodynamic stimuli implicate in adverse left ventricular remodeling (LVR). This is particularly identifiable in treatment-resistant and secondary hypertension contexts, like primary hyperaldosteronism (PA), however little data exists on post-treatment residual LVR in these individuals.

Methods
Cardiac magnetic resonance (CMR) with T1 mapping were performed in 14 patients with treated PA matched with 15 treated patients with primary hypertension (PH) and 15 healthy individuals. Blood pressure (BP) control was defined as < 140 x 90mmHg.

Results
Treated PA and PH patients had similar indexed left ventricular, extracellular matrix and intracellular masses (respectively 68 ± 12g/m2, 17 ± 3g/m2 and 52 ± 10g/m2 for PA vs 63 ± 18g/m2, 16 ± 5g/m2 and 47 ± 14g/m2 for PH, p > 0.05 for all), that were significantly higher than normal individuals (47 ± 8g/m2, 11 ± 2g/m2 and 36 ± 6g/m2, respectively, p < 0.05 for all). Patients with uncontrolled BP exhibited greater cardiomyocyte hypertrophy than those controlled (55 ± 11 g/m2 vs 43 ± 11 g/m2, p = 0.01), regardless of the cause of hypertension. PH individuals had strong correlations between BP measurements and LVR parameters of the CMR, while in PA correlations were weaker.

Conclusions
In treated patients with PA and PH, CMR detected similar residual tissue LVR in both groups. Uncontrolled BP was more related to the observed LVR than to the etiology of hypertension. BP levels were more strongly correlated to CMR LVR parameters in PH than PA patients.
MODEL REGRESI LOGISTIK PENCIPTAAN PROTOTIPE SEBAGAI LUARAN AKTIVITAS LITBANG INDUSTRI
Authors: Sugiono Shiddiq , Purnomo Dimas Hardy , Dinati Dindha Fadhilah 
Published: December 2024

Persaingan ketat di sektor Industri telah memaksa setiap perusahaan untuk berinovasi pada produknya. Sebagai salah satu hasil penelitian dan pengembangan di sektor industri, prototipe memainkan peran untuk mendukung terciptanya inovasi produk. Tujuan penelitian ini adalah untuk memodelkan dampak belanja, jumlah personil, skema jenis kerjasama litbang dan skala industri terhadap status penciptaan prototipe dalam lingkup industri. Analisis dilakukan pada data hasil Survei Litbang Industri Indonesia tahun 2021 melalui regresi logistik. Adapun regresi yang dilakukan menggunakan stepwise untuk menghasilkan model dengan variabel yang memiliki tingkat signifikansi terbaik. Hasil penelitian menyebutkan bahwa jumlah personil litbang, skala industri, kerjasama SDM dengan institusi asing dan kerjasama pendanaan dengan pemerintah pusat menjadi faktor yang signifikan dalam menghasilkan luaran prototipe. Industri skala menengah cenderung lebih banyak menghasilkan prototipe jika dibandingkan skala besar. Adapun kerjasama pendanaan dari Pemerintah Pusat merupakan aspek yang memiliki signifikansi paling tinggi dalam mempengaruhi luaran prototipe. Investasi SDM litbang yang kompeten bisa menjadi solusi untuk mengantisipasi kecilnya nilai odds ratio pada variabel jumlah SDM litbang. Selain itu, otoritas yang berwenang perlu terus meningkatkan ekosistem pendanaan riset industri yang lebih baik. [Logistic Regression Model of Prototype Creation as an Output of Industrial R&D Activities] Intense competition has forced every company to innovate its products. As one of the research and development outputs in the industrial sector, prototypes play a role to support the creation of product innovation. The purpose of this study is to model the impact of expenditure, number of personnel, type of R&D cooperation scheme and industry scale on the status of prototype creation in the industrial scope. The analysis was carried out on the data from the Indonesian Industrial R&D Survey 2021 through logistic regression. The regression was carried out using stepwise to produce the best model. The results stated that the number of R&D personnel, industry scale, HR cooperation with foreign institutions and funding cooperation with the central government were significant factors in producing prototype output. Medium-scale industries tend to produce more prototypes than large-scale ones. Funding cooperation from the central government is the aspect that has the highest significance in influencing prototype output. Investment in competent R&D human resources can be a solution to anticipate the small value of the odds ratio on the variable number of R&D human resources. In addition, the competent authority needs to continue to improve a better industrial research funding ecosystem.Keywords: industrial R&D; prototypes; R&D expenditure; R&D personnel; R&D cooperation; R&D resources
Industrial high saline water desalination by activated carbon in a packed column- an experimental and CFD study
Authors: Mahmoodabadi Hamideh , Goharrizi Ataallah Soltani 
Published: December 2024

Abstract
Salt adsorption from water onto the activated carbon was studied by a set of batch adsorption tests. Isotherms (Langmuir, Freundlich, Halsey and Redlich-Peterson) were used to study the experimental data for the adsorption isotherm analyzed. For magnesium, R
2 is equal to 0.98 for all isotherms, and for calcium, the Langmuir value is 0.97, while for sodium, the Langmuir value is 0.98, which is more suitable than the other isotherms. The experimental data were examined using three kinetic models, including first-second-order and intra-diffusion ones with R

2
value of 0.96, 0.67 and 0.93 respectively. According to the kinetic models, the first -order isotherm model better fit adsorption on the surface of activated carbon, as compared to other models. Similarly, the results of the experiment were provided via the computational fluid dynamics evaluation. Moreover, the results obtained by CFD were compared with the experimental data, and their accuracy was proved. Subsequently, the effects of changing the design and operating parameters, including flow rate (6, 12, 30 L min−1) and bed height (5, 10, 20 cm), on the performance of this tower were studied. The results showed that by reducing the adsorbent, the adsorbed metals increased and a longer bed was required for adsorption, which was not cost-effective. The amount of adsorption decreased as the flow rate increased, indicating that there was little contact between the metals and the adsorbent.
Hypnosis, Aesthetics, and Sociality: On How Images Can Create Experiences
Authors: Arlandis Castro Jaime 
Published: December 2024

Abstract
In this article, I use Object Oriented Ontology’s (OOO) account of metaphor as a perspective on the topic of hypnosis and some related phenomena. This analysis shows the potential of OOO’s theory of aesthetics to be informative outside of the usual realm of aesthetics, while simultaneously highlighting some of its shortcomings. Understanding hypnosis from this aesthetic point of view can be illustrative of the ways in which our experience is more generally mediated by factors outside of our conscious awareness. In particular, I will take advantage of this understanding to convey a message of caution regarding how we carry out psychological experiments and scientific research at large. At the same time, the connections drawn in this work highlight the central role played by social dimensions in aesthetic situations and should serve to highlight the need to bring forth such dimensions when thinking about aesthetics in OOO.
Museen, Objekte und Praktiken
Authors: Wagner Bernd , Zehbe Klaus-Christian 
Published: December 2024

Abstract
Immaterielles Kulturerbe im Rahmen des 2003er Übereinkommens der United Nations Educational, Scientific and Cultural Organization (UNESCO) ist eine Kategorie von Kulturerbe, die oft nur von bestimmten Personen an bestimmten Orten und zu bestimmten Zeiten ausoder aufgeführt wird. Viele Menschen kommen weder in Institutionen noch in ihrem Alltag in Berührung mit diesem Erbe; dies betrifft besonders Kinder. Der an Sachlernprozessen mit Sammlungsobjekten orientierte, didaktische Beitrag setzt hier an. Am Beispiel von Kontaktzonen für Grundschulkinder in historischen Sammlungen wird der Frage nachgegangen, ob und wie sich Kinder aus der Bedeutungsvielfalt von materiellem Kulturerbe (Hahn 2016) immaterielles Kulturerbe erschließen können und wie das Immaterielle Kulturerbe für Perspektiven von Kindern und eine Gestaltung von Zukunft geöffnet werden kann.
Bildung durch immaterielles kulturelles Erbe
Authors: Wulf Christoph 
Published: December 2024

Abstract
In Deutschland schaffen Millionen Menschen vielfältige Formen des immateriellen kulturellen Erbes und mit ihnen wertvolle Praktiken lebendiger Kultur. Mit der Erweiterung des Kulturbegriffs in den achtziger Jahren des letzten Jahrhunderts wurde diese kulturelle Produktivität immer mehr Menschen bewusst. Seither lassen sich unterscheiden ein Kulturbegriff im engeren Sinne, der der UNESCO-Konvention von 1972 zugrunde liegt, und ein Kulturbegriff im weiteren Sinne, der die Grundlage der UNESCO-Konvention von 2003 bildet. Heute wird betont, dass beide Kulturbegriffe mit ihren Formen ineinander verwoben sind. Daher ist es eher richtig, ihre Gemeinsamkeiten als ihre Unterschiede zu betonen. Beide Formen der Kultur schaffen eine gesellschaftliche und soziale Identität. Besonders der weitere Kulturbegriff hat eine erhebliche Bedeutung für die Erziehungs- und Bildungsprozesse der nachwachsenden Generation. Sein Bildungswert wird bislang im Erziehungsund Bildungssystem kaum gesehen. Ihn zu verdeutlichen, ist Ziel dieses Artikels.
Patient characteristics in relation to opioid exposure in a chronic non-cancer pain population
Authors: Grelz Henrik , Jakobsson Ulf , Midlöv Patrik , Fischer Marcelo Rivano , Ringqvist Åsa 
Published: December 2024

Abstract

Objectives
The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioid use disorder or overdose in relation to opioid dosage.

Method
A cross-sectional study was conducted at a Swedish tertiary pain rehabilitation clinic serving CnCP patients. The study population comprised 1,604 patients ≥18 years old registered in the Swedish Quality Registry for Pain Rehabilitation between 2018 and 2020. Data on dispensed opioids were extracted from the Swedish Prescribed Drug Register. Dependent variables were as follows: LTOT vs non-LTOT and exposed opioid dosage <50 mg morphine equivalent/day (MME/day) vs ≥50 MME/day.

Results
Of the included patients, 681 (42.5%) had at least one dispensation of opioids 180 days prior to assessment, 601 with a calculated opioid dosage ≥1 MME/day, and 424 (26.4%) were exposed to LTOT. The type of opioid prescribed was, in descending order, oxycodone (42.3% of all dispensations), codeine in combination with paracetamol (17.6%), tramadol (13.8%), and morphine (8.1%). A total of 89 cases had dosages of ≥50 MME/day and 430 patient dosages <50 MME/day. Patients exposed to LTOT exhibited an increased odds ratio (OR) of 2.685 (95% CI, 1.942–3.711) for concomitant use of benzodiazepines and male sex (OR, 1.694; 95% CI, 1.227–2.337). Patients receiving doses ≥50 MME/day were all, except one, exposed to LTOT. The concomitant use of benzodiazepines (OR 1.814, 95% CI 1.264–3.331) and male sex (OR, 1.777; 95% CI, 1.178–3.102) indicated a higher OR for opioid doses ≥50 MME/day.

Conclusions
LTOT strongly influenced the opioid dose. Furthermore, concomitant benzodiazepine dispensation and male sex were over-represented in patients exposed to LTOT as well as those exposed to opioid doses ≥50 MME/day.
The significance of taurine for patients with Crimean-Congo hemorrhagic fever and COVID-19 diseases: a cross-sectional study
Authors: Çelik Şimşek , Aydın Hüseyin , Tekin Yusuf Kenan , Ertemur Zeynep , Korkmaz İlhan , Yurtbay Sefa , Engin Aynur 
Published: December 2024

Abstract

Objectives
In this study, we aimed to evaluate the change in taurine levels in two diseases [Crimean-Congo hemorrhagic fever (CCHF) and novel coronavirus disease (COVID-19)], which have a significant impact on public health as they frequently cause mortality and morbidity.

Methods
This observational, cross-sectional study was conducted between September 15, 2023, and November 30, 2023, at the Emergency Department, Sivas Cumhuriyet University Faculty of Medicine. There were three groups in our study. These groups were 35 COVID-19 patients with confirmed diagnosis, 35 CCHF patients, and a control group consisting of 35 healthy volunteers who were similar to these patient groups in terms of age and gender. Plasma amino acid levels of taurine, β-alanine, arginine, carnosine, cystine, histidine, lysine, and methionine were measured and compared in these three groups.

Results
In the pairwise comparison of the groups, the increase in taurine plasma levels in CCHF (p<0.001) and COVID-19 (p=0.002) patients compared to the control group was statistically significant, whereas the difference between CCHF and COVID-19 patient groups was not significant (p=0.303). Multinomial logistic regression analysis revealed that taurine, β-alanine, arginine, and lysine levels were significant predictors in differentiating patients with CCHF and COVID-19 from healthy individuals.

Conclusions
We concluded that it may be important to determine taurine levels during the treatment and observation processes of these two diseases, which seriously affect public health. This study will contribute to a better understanding of the pathogenesis of the CCHF and COVID-19 diseases.
RESENHA DO LIVRO CONSERVATION PRATICES ON ARCHAEOLOGICAL EXCAVATION: PRINCIPLES AND METHODS. CORRADO PEDELI E STEFANO PULGA, 2013.
Authors: De Aguiar Silva Azevedo Paula 
Published: December 2024

Resumo: Na busca da conservação de qualquer material é necessário entender as suas particularidades, perceber as suas necessidades e aprender as características do contexto desse material. Quando falamos de remanescentes arqueológicos, nosso entendimento deve alcançar toda a sua trajetória, sendo imprescindível que a conservação desses materias se dê desde a escavação arqueológica. No livro Conservation Pratices on Archaeological Excavation: Principles and Methods de Conrrado Pedeli e Stfano Pulga, temos importantes informações sobre princípios e métodos de conservação in situ, numa visão ampla que abarca diversas tipologias de materiais e sítios arqueológicos. Se constituindo como um guia que direciona as ações do conservador-restaurador. Abstract: In the search for the conservation of any material it is necessary to understand its particularities, perceive its needs and learn the characteristics of the context of this material. When we speak of archaeological remnants, our understanding must reach all its trajectory, being essential that the conservation of these materials is given since the archaeological excavation. In the book Conservation Pratices on Archaeological Excavation: Principles and Methods by Conrrado Pedeli and Stfano Pulga, we have important information on principles and methods of in situ conservation, in a broad vision that encompasses several types of archaeological materials and sites. Constituting itself as a guide that directs the actions of the conservative-restorer.
Uma perspectiva metodológica para o estudo epigráfico: O caso de Sagunto ( I d.C.)
Authors: Campos Carlos Eduardo da Costa 
Published: December 2024

RESUMO: A proposta é de apresentar uma metodologia para análise epigráfica que seja útil aos pesquisadores de História. Afinal, acreditamos que metodologia para epigrafia pode auxiliar a extrair diversas informações preciosas para uma pesquisa que poderiam ser omitidas em uma análise superficial. Assim iremos expor as etapas e categorias de análise com um estudo de caso sobre a cidade romana de Sagunto, no século I d.C..ABSTRACT: The paper is a somewhat indirect part of the 'theme essay' around which the present volume is organized. The proposal is to present a methodology for epigraphic analysis that is useful to researchers of history. We focus on segmenting the methodology. Therefore, it has the interest to provide a more thorough analysis and more details about the information contained in the epigraphs.
The Enduring Legacy of the First Nesvizh Radziwill Ordination Library in Lithuania: Results of Recent Research
Authors: Misiūnienė Jadvyga 
Published: December 2024

The year 1749 is considered the beginning of the Nesvizh Radziwill Ordination Library. It was in this year that, by order of Michał Kazimierz Radziwiłł ‘Rybeńko’ (1702–1762), the Grand Hetman of Lithuania and Voivode of Vilnius, a new building was erected in Nesvizh specifically for the castle’s library. The Grand Ducal Library established there accumulated three collections of books: the old Nesvizh collection, the Biały Palace collection, and the collection of Jacob Heinrich von Flemming (1667–1728), the former Prime Minister of Augustus II and brother-in-law of Radziwiłł ‘Rybeńko’. In 1772, the Radziwiłł Ordination Library – the largest private book collection in the entire Polish-Lithuanian Commonwealth at the time – was taken away from Nesvizh by the Russian army as a war trophy. This article discusses the legacy of the First Nesvizh Radziwiłł Ordination Library that has survived in the libraries of Lithuanian memory institutions and private collections. It examines the provenance marks of the books, compiles a bibliographic list of books (manuscripts), and supplements it with new findings. Based on the results of historical and provenance research, some erroneous statements that have persisted in Lithuanian historiography have been corrected.