bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Wound Nursing Assessment and Clinical Outcomes in Patients with Cardiac Implantable Electronic Devices
Authors: Do Carmo J , Maria Joao Ferreira MJF , Ana Filipa Carvalho AFC , Catarina Oliveira CO , Antonio Pinto AP , Pedro Silva Cunha PSC , Rui Ferreira RF , Mario Oliveira MO 
Published: July 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public hospital(s). Main funding source(s): Centro Hospitalar Universitário Lisboa Central / Hospital Santa Marta
With the gains in life expectancy of patients (P) with heart disease, population with cardiac implantable electronic devices (CIED) therapy for the treatment of heart failure and life-threatening arrhythmias has increasingly became a challenge, regarding the number of complications following an implantation. Aim: To analyze clinical outcomes of P with CIED participating in an integrated nursing approach in an outpatient clinic of a tertiary center. Methods: Systematic review of clinical follow-up data of P undergoing CIED implantation who were observed by a specialized nursing team after discharge. Data regarding complications related to the surgical wound, treatment, timings and outcomes were collected. Results: In 2020, out of 927 P treated with CIED in our center, 157 were referred to the nursing outpatient clinic due high risk features such as anticoagulation and frailty, previously identified surgical wound related complications or advanced hearth failure. The CIED observed were replaced devices (17%), cardioverter defibrillator (41%), cardiac resynchronization therapy with defibrillator (27%), pacemakers (11%), and event recorders (4%). In average, the first appointment took place 16 days after the procedure. In 73 cases, presenting with pocket complaints (hematoma - 34%, local edema or pain - 10%, wound scab - 36%, exteriorized suture or staple - 20%), the average number of days until medical discharge was 36 days, with an average of 5 appointments per patient. In this group, 42% were under oral coagulants, 38% under antiaggregant drugs and 11% under both. Treatment options included antibiotic prescription in 25% of the cases, cryotherapy in 22%, dressing of the surgical wound in 10% and absorbable suture or staple removal in 10%. Four P (0.43%) were submitted to complete system removal due to CIED infection. Conclusions: Surgical wound related complaints in CIED P are relatively common and represent a factor of morbidity and increase in public health spending. An integrated trained team may aid in the prompt identification and management of these complications.
Symptomatic arterial hypertension in extrasystolic arrythmia
Authors: Germanova O , Germanov AV , Galati G , Shchukin YV 
Published: July 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.
Within the main causes of the secondary arterial hypertensions the main roles play renal, endocrine and hemodynamic. In the list of reasons of the secondary hemodynamic arterial hypertension there’re no extrasystoles.
Purpose. To determine the relationship between different types of extrasystoles and the the secondary hemodynamic arterial hypertension.
Materials and methods. We observed 132 patients with supraventricular and ventricular extrasystoles. Extrasystoles were divided into groups due to the moment of their appearance in cardiocycle:
1. Extrasystoles before the mitral valve opening.
2,3. Exstrasystoles in phase of fast ventricules filling before and after the peak of transmitral blood flow.
4. Extrasystoles in slow ventricules filling phase.
5. Other extrasystoles (allorrhythmias and group extrasystoles).
The reason for that dividing was the different contribution of each type into the hemodynamics and heart output. We analyzed the regular, extraordinary and first post-extrasystolic contractions. Intra-arterial blood flow was estimated by ultrasound-doppler. The moment of extrasystoles appearance was determined by echocardiography, electrocardiography and 24-hours ECG monitoring. The kinetics of vessel wall was calculated by sphygmograms and included speed, acceleration, power and work parameters.
The BP measuring was made by Korotkov method that the moment of measuring was in the first post-extrasystolic wave on sphygmogram. We duplicated it after the normalization and calibration of carotid arteries sphygmograms.
Results. The main importance to the hemodynamic changes has the moment of extrasystole appearance in cardio cycle and the ability of the first post-extrasystolic contraction to reestablish an adequate resulting blood flow. It is characterized by: stroke volume rising from 5 to 40%; systolic BP increase up to 30% (with formation of the secondary hemodynamic AH) compared with the systolic BP with normal heart rate; rising of arterial walls kinetic parameters (speed, acceleration, power, work); blood flow velocity rising; grown arterial wall deformation. The maximum of these parameters was in first post-extrasystolic contraction with extrasystoles before the mitral valve opening and extrasystoles before the transmitral peak blood outflow.
The special hemodynamic situation appears when there’re allorrhythmias when, for example, in case of constant bigeminia, BP is increased in 50% of time, and in case of trigimenia – in 1/3 of time.
Conclusion. We believe it’s necessary to include extrasystoles into the list of the reasons of the secondary hemodynamic arterial hypertension. The main features of this type of AH are: unstable BP rising, prevalence growth of systolic BP, direct relationship with extrasystoles’ appearance moment. The risen blood flow of first post-extrasystolic contraction can be the reason of additional arterial walls deformation and complications that may cause the any AH.
A prospective longitudinal study of health-related quality of life and psychological wellbeing after an implantable cardioverter defibrillator in patients with genetic heart diseases
Authors: Van Den Heuvel LM , Sarina T , Sweeting J , Yeates L , Bates K , Spinks C , O"donnell C , Sears SF , Mcgeechan K , Semsarian C , Ingles J 
Published: July 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): NHMRC Project Grant National Heart Foundation Future Leader Fellowship

OnBehalf
Cardio Genomics Program

Introduction
Genetic heart diseases, often affecting young people, can be clinically heterogeneous and pose an increased risk of sudden cardiac death (SCD). The implantable cardioverter defibrillator (ICD) is a lifesaving therapy. Impact on prospective and long-term psychological and health-related quality of life (HR-QoL) after ICD implant in patients with genetic heart diseases is unknown.

Purpose
We aimed to investigate the psychological functioning and HR-QoL over time in patients with genetic heart diseases who receive an ICD and to identify risk factors for poor psychological functioning and HR-QoL.

Methods
A prospective longitudinal design was used. Patients diagnosed with a genetic heart disease for which they received an ICD, were eligible. Anxiety, depression, health-related quality of life and device acceptance were measured using validated questionnaires. Baseline surveys were completed prior to ICD implantation with five-year follow-up after ICD implant.

Results
Forty patients with an inherited cardiomyopathy or arrhythmia syndrome (mean age 46.3 ± 14.2 years; 65.0% males) were included. Mean psychological and HR-QoL measures were within normative ranges during follow-up. We observed significant overall improvements from baseline to first follow-up with variability increasing after 36 months. The presence of comorbidities predicted worse physical HR-QoL (p = 0.014). Other predictors were not statistically significant, although lower education and female gender seemed to be an interesting predictor for higher anxiety and less mental HR-QoL, and the presence of comorbidities for less physical HR-QoL.

Conclusion
While the majority of patients with a genetic heart disease adjust well to their ICD implant, a subset of patients experiences poor psychological and HR-QoL outcomes.
Reducing Resistance: The Impact of Nonfollowers’ and Followers’ Parasocial Relationships with Social Media Influencers on Persuasive Resistance and Advertising Effectiveness
Authors: Breves Priska , Liebers Nicole , Motschenbacher Bernadette , Reus Leonie 
Published: July 2021

AbstractAlthough social media influencers have become popular brand endorsers, previous research on this new form of advertising has neglected to analyze how the followers of these influencers are persuaded. Based on a key mechanism proposed by the entertainment overcoming resistance model, long-term parasocial relationships (PSRs) should reduce the amount of persuasive resistance in the forms of reactance and counterarguing. Consequently, the persuasive effects should be enhanced. To empirically test these assumptions, two online studies were conducted. The first experimental study (N = 151) confirmed that followers experienced stronger PSRs than did nonfollowers, which resulted in higher perceived source trustworthiness and reduced levels of both perceived freedom threat and counterarguing after exposure to a sponsored Instagram post. The second study (N = 225) further confirmed the enhanced persuasive impact of PSRs in terms of brand evaluations and behavioral intentions. The theoretical and practical implications for advertisers, consumer advocates, and future research are discussed.
Variation in hospital performance measures from the Turkey Ministry of Health
Authors: Saluvan Mehmet , Milliren Carly E , Graham Dionne A , Simsekler Mecit Can Emre , Babacan Akin Merve , Koçatakan Pinar , Gören Mustafa , Ozonoff Al 
Published: July 2021

Abstract

Background
The Turkish healthcare system has seen broad population-based improvements in expanded health insurance coverage and access to healthcare services. Hospital performance in this national system is understudied. We aimed to identify trends in hospital performance over time following implementation of the Health Transformation Program and describe how regional outcomes correlate with regional vital statistics.

Objective
We examine hospital performance data collected by the PHA from 2013 to 2015. We aim to identify the temporal variation in hospital performance for nearly 30 individual measures and to describe the relationship between hospital-level performance measures and regional vital statistics.

Methods
We conducted a retrospective cohort study of 674 public hospitals in Turkey using baseline data from 2013 and follow-up data from 2014–15 collected by the Turkish Statistical Institution and the Public Hospital Agency. We report demographic and socioeconomic data across 12 geographic regions and analyze 29 hospital-level performance measures across four domains: (i) health services; (ii) administrative services; (iii) financial services and (iv) quality measures. We examine temporal variation, and study correlation between performance measures and regional vital statistics. We fit mixed-effects linear regression models to estimate linear trend over time accounting for within-hospital residual correlation. We prepared our manuscript in accordance with guidelines set by the STROBE statement for cohort studies.

Results
During the 3 years of study period, 21 of 29 measures improved and 8 measures worsened. All but three measures demonstrated significant differences across regions of the country. Several measures, including inpatient efficiency, patient satisfaction and audit score, are associated with regional infant mortality and life expectancy.

Conclusions
Evidence of temporal improvement in hospital-level performance may suggest some positive changes within the Turkish national healthcare system. Correlation of some measures with regional level health outcomes suggests a quality measurement strategy to monitor performance changes in the future. Although hospital-level functions have improved performance, the results of our study may help achieve further improvement for the health of the country’s citizens.
A cross-species comparison of antiretroviral penetration into lymph nodes using novel physiologically based pharmacokinetic models
Authors: Scholz Erin M B , Cao Yanguang , Kashuba Angela D M 
Published: July 2021

Abstract

Background
Investigating antiretroviral (ARV) penetration and pharmacology in lymph nodes is crucial to understanding mechanisms of HIV persistence in tissue, but sampling these tissues in humans is invasive and costly. Physiologically based pharmacokinetic (PBPK) modelling is a non-invasive solution for understanding lymph node penetration of ARVs across multiple species.

Objectives
To develop customized PBPK models with a novel lymph node compartment, and use these models to describe the distribution of three ARVs—tenofovir, emtricitabine and efavirenz—into the plasma and lymph nodes of non-human primates (NHPs) and humans.

Materials and methods
In this analysis, we utilized standard monkey and human PBPK models in PK-Sim, and added a novel lymph node compartment using MoBi. We used these models to describe the distribution of tenofovir, emtricitabine and efavirenz into NHP and human plasma and lymph nodes, and compared model-predicted versus observed AUC and Cmax.

Results
For all three ARVs, population simulations using the base and final models reasonably characterized observed plasma and tissue data in NHPs and humans, with predicted/observed AUC and Cmax ratios within 0.7–2.0.

Conclusions
Overall, our novel PBPK model provides a framework for understanding lymph node penetration of ARVs or future HIV cure therapies.
An Exploratory Study Demonstrating That Salivary Cytokine Profiles Are Altered in Children With Small Area Thermal Injury
Authors: Carlton Morgan , Voisey Joanne , Jones Lee , Parker Tony J , Punyadeera Chamindie , Cuttle Leila 
Published: July 2021

AbstractSerum can be used to investigate changes in cytokine concentration following burn injury in children; however, for children receiving treatment in an outpatient setting, blood is not routinely collected and therefore cannot be used for monitoring. The aim of this study was to investigate the use of saliva as a noninvasive tool for predicting burn outcomes by measuring the concentration of salivary cytokines in children with small area burns. A multiplex cytokine assay was used to measure 17 cytokines in the saliva of pediatric patients with burns (n = 20) and healthy controls (n = 20). After the removal of cytokines that had &gt;30% of samples below the assay lower detection limit, six cytokines including IL-1β, IL-4, IL-7, IL-8, MCP-1, and TNFα were analyzed for association with burns. IL-1β and IL-4 were found to be significantly elevated in the pediatric burn patients compared to healthy controls. Interestingly, IL-1β was also significantly elevated in scald burns, compared to contact burns. In addition, biologically meaningful differences in cytokine concentration were identified in patients with different burn characteristics, which warrant further investigation. This exploratory study provides evidence that cytokines can be detected in the saliva of children and that salivary cytokine profiles differ between healthy controls and children with burns. Overall, this study demonstrates the value of saliva for the investigation of cytokines and its potential application in pediatric diagnostics, specifically in situations where blood collection is not appropriate.
miR825-5p targets the TIR-NBS-LRR geneMIST1and down-regulates basal immunity againstPseudomonas syringaein Arabidopsis
Authors: López-Márquez Diego , Del-Espino Ángel , López-Pagán Nieves , Rodríguez-Negrete Edgar A , Rubio-Somoza Ignacio , Ruiz-Albert Javier , Bejarano Eduardo R , Beuzón Carmen R 
Published: July 2021

AbstractPlants encode numerous intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) that recognize pathogen-derived effectors or their activity to activate defenses. miRNAs regulate NLR genes in many species, often triggering the production of phased siRNAs (phasiRNAs). Most such examples involve genes encoding NLRs carrying coiled-coil domains, although a few include genes encoding NLRs carrying a Toll/interleukin-1 domain (TNL). Here, we characterize the role of miR825-5p in Arabidopsis, using a combination of bioinformatics, transgenic plants with altered miRNA levels and/or reporters, small RNAs, and virulence assays. We demonstrate that miR825-5p down-regulates the TNL MIST1 by targeting for endonucleolytic cleavage the sequence coding for TIR2, a highly conserved amino acid motif, linked to a catalytic residue essential for immune function. miR825-5p acts as a negative regulator of basal resistance against Pseudomonas syringae. miR825-5p triggers the production from MIST1 of a large number of phasiRNAs that can mediate cleavage of both MIST1 and additional TNL gene transcripts, potentially acting as a regulatory hub. miR825-5p is expressed in unchallenged leaves and transcriptionally down-regulated in response to pathogen-associated molecular patterns (PAMPs). Our results show that miR825-5p, which is required for full expression of PAMP-triggered immunity, establishes a link between PAMP perception and expression of uncharacterized TNL genes.
The proline cycle as an eukaryotic redox valve
Authors: Zheng Yao , Cabassa-Hourton Cécile , Planchais Séverine , Lebreton Sandrine , Savouré Arnould 
Published: July 2021

Abstract
The amino acid proline has been known for many years to be a component of proteins as well as an osmolyte. Many recent studies have demonstrated that proline has other roles such as regulating redox balance and energy status. In animals and plants, the well-described proline cycle is concomitantly responsible for the preferential accumulation of proline and shuttling of redox equivalents from the cytosol to mitochondria. The impact of the proline cycle goes beyond regulating proline levels. In this review, we focus on recent evidence of how the proline cycle regulates redox status in relation to other redox shuttles. We discuss how the interconversion of proline and glutamate shuttles reducing power between cellular compartments. Spatial aspects of the proline cycle in the entire plant are considered in terms of proline transport between organs with different metabolic regimes (photosynthesis versus respiration). Furthermore, we highlight the importance of this shuttle in the regulation of energy and redox power in plants, through a particularly intricate coordination, notably between mitochondria and cytosol.
Modelling of ionizing feedback with smoothed particle hydrodynamics and Monte Carlo radiative transfer on a Voronoi grid
Authors: Petkova Maya A , Vandenbroucke Bert , Bonnell Ian A , Kruijssen J M Diederik 
Published: July 2021

ABSTRACT
The ionizing feedback of young massive stars is well known to influence the dynamics of the birth environment and hence plays an important role in regulating the star formation process in molecular clouds. For this reason, modern hydrodynamics codes adopt a variety of techniques accounting for these radiative effects. A key problem hampering these efforts is that the hydrodynamics are often solved using smoothed particle hydrodynamics (SPH), whereas radiative transfer is typically solved on a grid. Here we present a radiation-hydrodynamics (RHD) scheme combining the SPH code phantom and the Monte Carlo radiative transfer (MCRT) code cmacionize, using the particle distribution to construct a Voronoi grid on which the MCRT is performed. We demonstrate that the scheme successfully reproduces the well-studied problem of D-type H ii region expansion in a uniform density medium. Furthermore, we use this simulation setup to study the robustness of the RHD code with varying choice of grid structure, density mapping method, and mass and temporal resolution. To test the scheme under more realistic conditions, we apply it to a simulated star-forming cloud reminiscing those in the Central Molecular Zone of our Galaxy in order to estimate the amount of ionized material that a single source could create. We find that a stellar population of several $10^3~\rm {M_{\odot }}$ is needed to noticeably ionize the cloud. Based on our results, we formulate a set of recommendations to guide the numerical setup of future and more complex simulations of star forming clouds.
Towards realistic modelling of the astrometric capabilities of MCAO systems: detecting an intermediate-mass black hole with MAVIS
Authors: Monty Stephanie , Rigaut François , McDermid Richard , Baumgardt Holger , Cranney Jesse , Agapito Guido , Mendel J Trevor , Plantet Cédric , Greggio Davide , Stetson Peter B , Fiorentino Giuliana , Haynes Dionne 
Published: July 2021

ABSTRACT
Accurate astrometry is a key deliverable for the next generation of multiconjugate adaptive optics (MCAO) systems. The MCAO-Assisted Visible Imager and Spectrograph (MAVIS) is being designed for the Very Large Telescope Adaptive Optics Facility and must achieve 150 $\mu$as astrometric precision (50 $\mu$as goal). To test this before going on-sky, we have created MAVIS Image Simulator (mavisim), a tool to simulate MAVIS images. mavisim accounts for three major sources of astrometric error: high- and low-order point spread function (PSF) spatial variability, tip–tilt residual error, and static field distortion. When exploring the impact of these three error terms alone, we recover an astrometric accuracy of 50 $\mu$as for all stars brighter than m = 19 in a 30 s integration using PSF-fitting photometry. We also assess the feasibility of MAVIS detecting an intermediate-mass black hole (IMBH) in a Milky Way globular cluster. We use an N-body simulation of an NGC 3201-like cluster with a central 1500 M⊙ IMBH as input to mavisim and recover the velocity dispersion profile from proper motion measurements. Under favourable astrometric conditions, the dynamical signature of the IMBH is detected with a precision of ∼0.20 km s−1 in the inner ∼4 arcsec of the cluster where Hubble Space Telescope (HST) is confusion limited. This precision is comparable to measurements made by Gaia, HST, and Multi Unit Spectroscopic Explorer (MUSE) in the outer ∼60 arcsec of the cluster. This study is the first step towards building a science-driven astrometric error budget for an MCAO system and a prediction of what MAVIS could do once on sky.
Context-sensitivity of isosteric substitutions of non-Watson–Crick basepairs in recurrent RNA 3D motifs
Authors: Khisamutdinov Emil F , Sweeney Blake A , Leontis Neocles B 
Published: July 2021

Abstract
Sequence variation in a widespread, recurrent, structured RNA 3D motif, the Sarcin/Ricin (S/R), was studied to address three related questions: First, how do the stabilities of structured RNA 3D motifs, composed of non-Watson–Crick (non-WC) basepairs, compare to WC-paired helices of similar length and sequence? Second, what are the effects on the stabilities of such motifs of isosteric and non-isosteric base substitutions in the non-WC pairs? And third, is there selection for particular base combinations in non-WC basepairs, depending on the temperature regime to which an organism adapts? A survey of large and small subunit rRNAs from organisms adapted to different temperatures revealed the presence of systematic sequence variations at many non-WC paired sites of S/R motifs. UV melting analysis and enzymatic digestion assays of oligonucleotides containing the motif suggest that more stable motifs tend to be more rigid. We further found that the base substitutions at non-Watson–Crick pairing sites can significantly affect the thermodynamic stabilities of S/R motifs and these effects are highly context specific indicating the importance of base-stacking and base-phosphate interactions on motif stability. This study highlights the significance of non-canonical base pairs and their contributions to modulating the stability and flexibility of RNA molecules.