bluuebunny/crossref_metadata_2025_split huggingface dataset:
De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors
Authors: Anazawa Yuzu , Kita Tomoki , Iguchi Rei , Hayashi Kumiko , Niwa Shinsuke 
Published: July 2021

AbstractKIF1A is a kinesin superfamily molecular motor that transports synaptic vesicle precursors in axons. Mutations in Kif1a lead to a group of neuronal diseases called KIF1A-associated neuronal disorder (KAND). KIF1A forms a homodimer and KAND mutations are mostly de novo and autosomal dominant; however, it is not known whether the function of wild-type KIF1A is inhibited by disease-associated KIF1A when they are dimerized. No reliable in vivo model systems to analyze the molecular and cellular biology of KAND caused by loss of function mutations have been developed; therefore, here, we established Caenorhabditis elegans models for KAND using CRISPR/cas9 technology and analyzed defects in axonal transport. In the C. elegans models, heterozygotes and homozygotes exhibited reduced axonal transport phenotypes. Suppressor screening using the disease model worm identified a mutation that recovers the motor activity of disease-associated human KIF1A. In addition, we developed in vitro assays to analyze the motility of single heterodimers composed of wild-type KIF1A and disease-associated KIF1A. Disease-associated KIF1A significantly inhibited the motility of wild-type KIF1A when heterodimers were formed. These data indicate the molecular mechanism underlying the dominant nature of de novo KAND mutations.Significance StatementKIF1A is a molecular motor that transports synaptic vesicle precursors in axons. Recent studies have identified many KIF1A mutations in congenital neuropathy patients; however, the molecular mechanism of pathogenesis remains largely elusive. This study established loss of function models for KIF1A-associated neuronal disorder (KAND) in Caenorhabditis elegans to analyze the molecular and cell biology of the disease in vivo. Genetic screening using the disease model could find a mutation that recovers the motor activity of disease-associated KIF1A. This study also established in vitro single-molecule assays to quantitatively analyze the effect of KAND mutations when mutant KIF1A forms heterodimers with wild-type KIF1A. Our findings provide a foundation for future genetic screening and for drug screening to search for KAND treatments.
The on-orbit mission analysis of OTV based on DoDAF
Authors: Zheng Hongxing , Liu Xin , Wu Junhui , Man Yiyun , Xu Xibao , Guo Jifeng 
Published: July 2021

Purpose
The purpose of this paper is to improve the efficiency of on-orbit operations through the top-level task design based on DoDAF. Based on the existing upper stage rocket technology, orbit transfer vehicles (OTVs) have developed rapidly in recent years. However, the lack of decision guidance based on overall task analysis requires integrating top-level analysis and bottom-level execution to achieve the smooth development of full-process tasks.

Design/methodology/approach
Using the Department of Defense Architecture Framework (DoDAF) as a reference, this paper performs the top-level mission analysis modeling of the on-orbit rendezvous and capture of the OTV. Moreover, the typical operational view products are obtained, and the cooperative relations among the mission requirements, the system requirements, and the functional requirements are also analyzed.

Findings
The results show that the attitude of the OTV changes violently during the maneuver and rendezvous phases. In addition, the view products can be optimized based on the results.

Originality/value
The proposed DoDAF-based on-orbit task integration analysis method achieves the effective fusion of high-level analysis and bottom-level execution of OTV on-orbit rendezvous and capture task through the top-level task modeling, operation view generation and task relationship analysis. According to the requirements and constraints of the on-orbit rendezvous and capture task, the control instructions of the vehicle are efficiently generated under the DoDAF framework.
Predefined-time control for a horizontal takeoff and horizontal landing reusable launch vehicle
Authors: Zhang Liang , Jing Liang , Ye Liheng , Gao Xing 
Published: July 2021

Purpose
This paper aims to investigate the problem of attitude control for a horizontal takeoff and horizontal landing reusable launch vehicle.

Design/methodology/approach
In this paper, a predefined-time attitude tracking controller is presented for a horizontal takeoff and horizontal landing reusable launch vehicle (HTHLRLV). Firstly, the attitude tracking error dynamics model of the HTHLRLV is developed. Subsequently, a novel sliding mode surface is designed with predefined-time stability. Furthermore, by using the proposed sliding mode surface, a predefined-time controller is derived. To compensate the external disturbances or model uncertainties, a fixed-time disturbance observer is developed, and its convergence time can be defined as a prior control parameter. Finally, the stability of the proposed sliding mode surface and the controller can be proved by the Lyapunov theory.

Findings
In contrast to other fixed-time methods, this controller only requires three control parameters, and the convergence time can be predefined instead of being estimated. The simulation results also demonstrate the effectiveness of the proposed controller.

Originality/value
A novel predefined-time attitude tracking controller is developed based on the predefined-time sliding mode surface (SMS) and fixed-time disturbance observer (FxTDO). The convergence time of the system can be selected as a prior control parameter for SMS and FxTDO.
Variables predicting the association between autistic traits and externalizing symptoms among young adults
Authors: Álvarez-Couto María , García-Villamisar Domingo , Sáez-Suanes Gema P. , d'Orey Roquete María 
Published: July 2021

Purpose
Considering the high comorbidity of autism spectrum disorder (ASD) with externalizing disorders and that ASD is considered as a continuum, which implies the identification of it features in the whole population, the purpose of this paper is to know the characteristics of the association of externalizing symptoms in the population with ASD traits.

Design/methodology/approach
One hundred and seventeen postsecondary students participated in the study, providing responses to a battery of self-reported tests.

Findings
The existence of a significant association between ASD and attention deficit hyperactivity disorder (ADHD) (0.519; p < 0.01) was proved. Regression analyses showed that problems in executive functioning, working memory deficits and difficulties in the use of emotion regulation strategies predicted the presence of ADHD traits (F = 36.757, R2 = 62.3%, p < 0. 01) and impulsivity behavior (F = 18.249, R2 = 45.1%, p < 0.01).

Research limitations/implications
Externalizing symptomatology in people with higher ASD traits is extended to the general population. Future research should study other problematic behaviors, such as aggression or self-harm, to continue generating appropriate interventions.

Originality/value
The results reported reinforce the study of ASD as a dimensional disorder, in line with the latest advances in the classification of psychopathology. Considering which variables are behind the problematic behaviors allows interventions to be focused on these factors, contributing to their reduction and to the improvement of professional practices.
Work-related identity discrepancy and employee innovation behavior: the role of intrinsic motivation and self-construal
Authors: Chen Yahui , Zhang Jianmin , Liu Chang-E , Liu Tingting , He Wei 
Published: July 2021

PurposeThe purpose of this paper is to investigate the role of intrinsic motivation and self-construal in explaining the relationship between work-related identity discrepancy and employee innovation behavior.Design/methodology/approachBased on a survey of 637 respondents from 15 organizations in southern China, this study examines four hypotheses with regard to the relationship between work-related identity discrepancy and employee innovation behavior through hierarchical regression analysis.FindingsThe research results indicate that work-related identity discrepancy is negatively related to employee innovation behavior, but intrinsic motivation mediates their negative relationship, and self-construal moderates this mediating effect further. Specifically, the results demonstrate that perceiving work-related identity discrepancy can lower intrinsic motivation among employees with interdependent self-construal and subsequently reduce their innovation behavior.Originality/valueDrawn on social cognitive theory, this study reveals the negative effect of work-related identity discrepancy on employee innovation behavior and the moderated mediation effect of intrinsic motivation and self-construal on the negative relationship. The finding expands existing literature on work-related identity discrepancy and employee innovation behavior.
Pareto-optimal front for multi-objective optimization of the suspension of a full-vehicle model in the frequency domain
Authors: Fossati Giovani Gaiardo , Miguel Letícia Fleck Fadel , Paucar Casas Walter Jesus 
Published: July 2021

PurposeThis study aims to propose a complete and powerful methodology that allows the optimization of the passive suspension system of vehicles, which simultaneously takes comfort and safety into account and provides a set of optimal solutions through a Pareto-optimal front, in a low computational time.Design/methodology/approachUnlike papers that consider simple vehicle models (quarter vehicle model or half car model) and/or simplified road profiles (harmonic excitation, for example) and/or perform a single-objective optimization and/or execute the dynamic analysis in the time domain, this paper presents an effective and fast methodology for the multi-objective optimization of the suspension system of a full-car model (including the driver seat) traveling on an irregular road profile, whose dynamic response is determined in the frequency domain, considerably reducing computational time.FindingsThe results showed that there was a reduction of 28% in the driver seat vertical acceleration weighted root mean square (RMS) value of the proposed model, which is directly related to comfort, and, simultaneously, an improvement or constancy concerning safety, with low computational cost. Hence, the proposed methodology can be indicated as a successful tool for the optimal design of the suspension systems, considering, simultaneously, comfort and safety.Originality/valueDespite the extensive literature on optimizing vehicle passive suspension systems, papers combining multi-objective optimization presenting a Pareto-optimal front as a set of optimal results, a full-vehicle model (including the driver seat), an irregular road profile and the determination of the dynamic response in the frequency domain are not found.
Entrepreneurial crowdfunding backer motivations: a latent Dirichlet allocation approach
Authors: St John Jeremy , St John Karen , Han Bo 
Published: July 2021

PurposeThis study furthers one’s understanding of the motivations of the crowdfunding crowd by empirically examining critical factors that influence the crowd's decision to support a crowdfunding project.Design/methodology/approachBacker's comments from a sample of the top 100 most funded technology product projects on KickStarter were collected. A latent Dirichlet allocation (LDA) analysis strategy was adopted to investigate critical motivational factors. Three experts mapped those factors to the known theoretical constructs of social exchange theory (SET).FindingsAlthough backers are motivated by value, they are also motivated by far less tangible social factors including trust and a feeling of psychological ownership. Findings suggest that the crowd is far more than a passive group of investors or customers and should be viewed as participatory stakeholders. This study serves as guidance for project owners hoping to motivate the crowd and for future investigators examining backer motivations in other types of crowdsourcing projects.Research limitations/implicationsOnline chatter in the form of user-generated comments is an excellent data source for researchers to mine for value and meaning.Practical implicationsGiven strong feelings of psychological ownership, project owners should actively engage the crowd and solicit the crowd for advice and help in order to motivate them.Originality/valueThe study presents the first empirical exploration of backer motivations using LDA guided by theory and the knowledge of experts. A framework of latent motivational factors is proposed.
Experiential learning model: improving entrepreneurial values through internship program at start-ups
Authors: Lantu Donald Crestofel , Suharto Yulianto , Fachira Ira , Permatasari Anggraeni , Anggadwita Grisna 
Published: July 2021

PurposeThe development of teaching methods in the field of entrepreneurship education is a challenge for academics to achieve “real active learning.” This paper aims to investigate the effectiveness of learning experience through internship program at start-ups. This paper examines the benefits and challenges from stakeholders' experiences and perspectives (business students, start-ups and universities). The authors focus on the entrepreneurial values obtained by exploring start-up processes, culture and work environments.Design/methodology/approachThis study uses qualitative research with a case study approach by applying experiential learning. The objects of this research are students of the School of Business and Management and start-ups in Indonesia. This study divides the pilot program of internship at start-ups into three stages, designing process, execution and evaluation. The analysis technique uses an interpretive approach from interviews and observations of internships based on experiential learning.FindingsThe results showed that the internship program at start-ups in this study has benefits for all major stakeholders, especially students. The results of student learning experiences show that start-ups' characteristics such as a creative work environment, egalitarian work culture and dynamic workflow flexibility can increase their professional and moral values.Research limitations/implicationsThis study has several limitations, including the internship program designed in this study, which is still raw and has several shortcomings. Time series in testing experiential learning is another limitation. For further study, it is necessary to conduct longitudinal research to measure the effectiveness of the start-ups' internship program.Originality/valueThis study provides new insights on experiential learning in developing an internship program at a start-up as an effort to increase entrepreneurial value for business students. This study highlights the possibility that an internship program at a start-up will have an impact on students' entrepreneurial values and competencies.
Analysis of construction delay for delivering quality project in Bangladesh
Authors: Hoque Md. Ikramul , Safayet Md. Abu , Rana Md. Jewel , Bhuiyan Abu Yousuf , Quraishy Golam Sadmani 
Published: July 2021

PurposeConstruction delay is the most common issue and creates many adverse effects in any construction industry. This study has investigated the views of engineers, project managers and contractors on the causes of delay during a construction phase to identify potential delay factors, negative effects on project delivery and prioritize the delay factors.Design/methodology/approachAn extensive literature review and interview with construction stakeholders have been conducted to identify potential causes of construction delays and design a questionnaire survey. The final questionnaire was designed with 40 potential delay factors, and a total of 102 valid Bangladeshi construction stakeholders responded to it. The result was analyzed by the relative importance index.FindingsAmong the 40 delay factors, the top five most influencing delay factors are “delay in progress payments,” “rework due to mistakes during construction,” “lack of skilled labor,” “poor monitoring and control of activities” and “delays in the making of a decision.” The top five most damaging effects of delay are “time overrun,” “cost overrun,” “disputes,” “arbitration” and “litigation,” among ten negative effects of construction delay. All construction stakeholders believe that the owner-related, consultant-related and contractor-related groups are the first, second and third most important groups of delay factors.Originality/valueThe outcome of this study would enable the Bangladeshi construction industry to develop strategies to overcome delay factors and their harmful effects. By focusing on the outcome of this research and prioritizing the critical factors, the construction industry of Bangladesh will be able to minimize construction delay significantly and propagate the progress of the construction industry by delivering quality projects timely.
Cost and environmental performance of forced air and hot water heating systems in post-Soviet countries
Authors: Kulmedov Begmyrat , Durdyev Serdar 
Published: July 2021

PurposeThe aim of the present study is to assess the selected heating systems (furnace and boiler) commonly used in the dwellings of seven post-USSR (the Union of Soviet Socialist Republics) countries. The systems were assessed in terms of their cost and environmental performance, with natural gas and electricity used as the main source of energy.Design/methodology/approachThe cost-effectiveness and environmental performance of the selected heating systems that have been commonly used in the selected post-USSR countries was assessed. Current energy (natural gas and electricity) prices that are applied in those countries were used.FindingsResults show that the furnace is the cheapest option, while natural gas is the cheapest source of energy, despite its high price in Tajikistan and Kyrgyzstan. Both heating systems could be considered eco-friendly options, although their efficiencies need to be considered at the design stage. Turkmenistan, Uzbekistan and Kazakhstan, which are the top natural gas producers, offer natural gas for the selected heating systems as both cost-effective and eco-friendly options.Practical implicationsA considerable reduction in electricity consumption and less harm to our environment can be achieved through the systems used in residential buildings in the region.Originality/valueThe outcomes of the present study offer value (in terms of cost-effective and eco-friendly options) for the end-users in the region.
Determinants of credit risk of Indonesian Sharīʿah rural banks
Authors: Priyadi Unggul , Utami Kurnia Dwi Sari , Muhammad Rifqi , Nugraheni Peni 
Published: July 2021

PurposeThis study aims to examine the influence of internal and external factors on the credit risk (represented by nonperforming financing [NPF]) of Indonesian Sharīʿah rural banks (SRBs) – a type of Islamic bank that provides Islamic financial services especially to small and medium businesses in Indonesia. Internal variables comprise capital adequacy ratio (CAR), financing to deposit ratio (FDR), return on assets (ROA), operating expense ratio (OER), financing to value (FTV) and profit and loss sharing (PLS) financing ratio. External variables comprise inflation, economic growth and interest rate.Design/methodology/approachThe study uses the annual reports of SRBs in Indonesia as secondary data for the years 2010–2019. Auto regressive distributed lag (ARDL) is used as the analysis method to examine the short-run and long-run relationships between the variables.FindingsThe findings indicate that four variables experienced a lag in the short run, namely, NPF, inflation, CAR and PLS, with different results recorded for each of the variables. Furthermore, the long-run results show that CAR and ROA influence the NPF of SRBs positively, whereas inflation and PLS have a negative influence on NPF. The rest of the variables – notably economic growth, interest rate, FDR, FTV and OER – do not have an influence on NPF in SRBs.Research limitations/implicationsThe level of NPF in SRBs exceeds the provision of the Central Bank of Indonesia. The findings are expected to have implications for SRBs and the regulator to consider and to manage the factors related to NPF properly due to the important role of SRBs in small and medium businesses’ development.Originality/valueThis study measures the determinants of NPF using internal and external variables, including the addition of a dummy variable, notably FTV. This study also uses ARDL to analyze the financial policies involving data at the present time and lagged time.
Board independence and private information-based trading: evidence from Malaysia
Authors: Khong Jiunn-Shyan , Hooy Chee-Wooi , Lye Chun-Teck 
Published: July 2021

PurposeThis study investigates the effect of board independence on private information-based trading (PIBT) events. This study also examines the interaction effects of firm's disclosure quality and the statutory and demographic roles of independent directors and board diversity attributes, respectively, on the relationship between board independence and PIBT.Design/methodology/approachThis study uses panel data of 811 non-financial public listed companies in Bursa Malaysia for the sample period 2009–2017. The dynamic general method of moments (DGMM) is used for the dynamic panel data estimation and to address the potential endogeneity problem.FindingsThe results show that board independence has a negative effect on PIBT and the effect could be strengthened by firm's disclosure quality, women independent directors and board gender diversity, but attenuated by CEO duality. The overall result suggests that apart from independent audit committee, the statutory and demographic attributes of independent directors and board diversity, and firm's disclosure quality are complementary to board independence in preventing persistent PIBT.Originality/valueThis study augments the existing corporate governance and information-based trading literature from the perspectives of firm's disclosure quality, and the statutory and demographic roles of independent directors and board diversity attributes, by examining their effects on the relationship between board independence and PIBT.