bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilingualism Effects on the Cognitive Flexibility of Autistic Children: Evidence From Verbal Dual-Task Paradigms
Authors: Peristeri Eleni , Vogelzang Margreet , Tsimpli Ianthi Maria 
Published: September 2021

Abstract
The deficit in cognitive flexibility (i.e., the ability to adapt cognitive behavior to changing contexts) is one of the most prominent characteristics of autistic individuals. Inflexibility may manifest in restricted interests and increased susceptibility to the effects of misinformation either through inefficient inhibition of non-target information or deficient recall of correct information. Bilingualism has been shown to enhance executive functions in both typically developing children and autistic children; yet, the effect of bilingualism on cognitive flexibility in autism remains underexplored. In this study, we used verbal dual-tasks to compare cognitive flexibility across 50 monolingual autistic and 50 bilingual autistic children, and 50 monolingual and 50 bilingual typically developing children. The children were also administered language ability tests and a nonverbal global-local cognitive flexibility task, in order to investigate whether performance in the dual-tasks would be modulated by the children’s language and executive function skills. The bilingual autistic children outperformed their monolingual autistic peers in the dual-tasks. The strength of the bilingualism effect, however, was modulated by the type of language processing that interfered with the target information in each dual-task, which suggests that the bilingual autistic children calibrated their processing resources and efficiently adapted them to the changing demands of the dual-task only to the extent that the task did not exceed their language abilities. Bilingual autistic children relied on their executive functions rather than on their language abilities while performing in the dual-tasks. The overall results show that bilingualism compensates for the reduced cognitive flexibility in autism.
The Intensity- and Size-Dependent Response of Tropical Cyclones to Increasing Vertical Wind Shear
Authors: Finocchio Peter M. , Rios-Berrios Rosimar 
Published: September 2021

AbstractThis study describes a set of idealized simulations in which westerly vertical wind shear increases from 3 to 15 m s−1 at different stages in the lifecycle of an intensifying tropical cyclone (TC). The TC response to increasing shear depends on the intensity and size of the TC’s tangential wind field when shear starts to increase. For a weak tropical storm, increasing shear decouples the vortex and prevents intensification. For Category 1 and stronger storms, increasing shear causes a period of weakening during which vortex tilt increases by 10–30 km before the TCs reach a near-steady Category 1–3 intensity at the end of the simulations. TCs exposed to increasing shear during or just after rapid intensification tend to weaken the most. Backward trajectories reveal a lateral ventilation pathway between 8–11 km altitude that is capable of reducing equivalent potential temperature in the inner core of these TCs by nearly 2°C. In addition, these TCs exhibit large reductions in diabatic heating inside the radius of maximum winds (RMW) and lower-entropy air parcels entering downshear updrafts from the boundary layer, which further contributes to their substantial weakening. The TCs exposed to increasing shear after rapid intensification and an expansion of the outer wind field reach the strongest near-steady intensity long after the shear increases because of strong vertical coupling that prevents the development of large vortex tilt, resistance to lateral ventilation through a deep layer of the middle troposphere, and robust diabatic heating within the RMW.
A Kilometer-Scale Coupled Atmosphere-Wave Forecasting System for the European Arctic
Authors: Thomas Erin E. , Müller Malte , Bohlinger Patrik , Batrak Yurii , Szapiro Nicholas 
Published: September 2021

AbstractAccurately simulating the interactions between the components of a coupled Earth modelling system (atmosphere, sea-ice, and wave) on a kilometer-scale resolution is a new challenge in operational numerical weather prediction. It is difficult due to the complexity of interactive mechanisms, the limited accuracy of model components and scarcity of observations available for assessing relevant coupled processes. This study presents a newly developed convective-scale atmosphere-wave coupled forecasting system for the European Arctic. The HARMONIE-AROME configuration of the ALADIN-HIRLAM numerical weather prediction system is coupled to the spectral wave model WAVEWATCH III using the OASIS3 model coupling toolkit. We analyze the impact of representing the kilometer-scale atmosphere-wave interactions through coupled and uncoupled forecasts on a model domain with 2.5 km spatial resolution. In order to assess the coupled model’s accuracy and uncertainties we compare 48-hour model forecasts against satellite observational products such as Advanced Scatterometer 10 m wind speed, and altimeter based significant wave height. The fully coupled atmosphere-wave model results closely match both satellite-based wind speed and significant wave height observations as well as surface pressure and wind speed measurements from selected coastal station observation sites. Furthermore, the coupled model contains smaller standard deviation of errors in both 10m wind speed and significant wave height parameters when compared to the uncoupled model forecasts. Atmosphere and wave coupling reduces the short term forecast error variability of 10 m wind speed and significant wave height with the greatest benefit occurring for high wind and wave conditions.
Cochlear Implantation Outcomes in Observed Vestibular Schwannoma: A Preliminary Report
Authors: Longino Elizabeth S. , Manzoor Nauman F. , Cass Nathan D. , Tawfik Kareem O. , Bennett Marc L. , O’Malley Matthew R. , Haynes David S. , Perkins Elizabeth L. 
Published: September 2021

ObjectiveOver the last decade there has been a trend toward observation for small nongrowing vestibular schwannoma (VS). Even without tumor growth, patients commonly experience ipsilateral hearing decline, and hearing rehabilitation remains challenging. This study analyzes hearing and speech performance outcomes after cochlear implantation (CI) in observed VS.Study DesignRetrospective review.SettingTertiary referral center.MethodsChart review was used to include patients with observed VS who had undergone ipsilateral CI, pre‐ and postimplantation audiometry, and speech performance. Tumor size pre‐ and postimplantation was measured with volumetric analysis.ResultsSeven patients with ipsilateral VS and CI were identified. Preimplantation tumor volume was 0.11 to 1.02 cm3. Five subjects were implanted with a straight electrode and two with a perimodiolar electrode. The average preimplant pure tone average was 91.3 dB (range, 80‐117 dB) and 61.2 dB (range, 12‐118 dB) for the implanted and nonimplanted ears, respectively. In all subjects with at least 1 year of listening experience (n = 6), consonant‐nucleus‐consonant word scores improved at 6 months and 1 year in the CI‐alone and bimodal listening conditions. AzBio scores in quiet also improved at 6 months and 1 year. Of subjects with serial pre‐ and postoperative magnetic resonance imaging, volumetric analysis demonstrated no tumor growth.ConclusionOur results demonstrate that CI is a successful option for subjects with small nongrowing VS. All subjects had improved performance postimplantation. VS may continue to be observed with serial magnetic resonance imaging given increasing conditionality among CI manufacturers and ability to assess cerebellopontine angle extension despite implant artifact.
HGAL inhibits lymphoma dissemination by interacting with multiple cytoskeletal proteins
Authors: Jiang Xiaoyu , Lu XiaoQing , Gentles Andrew J. , Zhao Dekuang , Wander Seth A. , Zhang Yu , Natkunam Yasodha , Slingerland Joyce , Reis Isildinha M. , Rabinovich Brian , Abdulreda Midhat H. , Moy Vincent T. , Lossos Izidore S. 
Published: September 2021

Abstract
Human germinal center–associated lymphoma (HGAL) is an adaptor protein specifically expressed in germinal center lymphocytes. High expression of HGAL is a predictor of prolonged survival of diffuse large B-cell lymphoma (DLBCL) and classic Hodgkin lymphoma. Furthermore, HGAL expression is associated with early-stage DLBCL, thus potentially limiting lymphoma dissemination. In our previous studies, we demonstrated that HGAL regulates B-cell receptor signaling and cell motility in vitro and deciphered some molecular mechanisms underlying these effects. By using novel animal models for in vivo DLBCL dispersion, we demonstrate here that HGAL decreases lymphoma dissemination and prolongs survival. Furthermore, by using an unbiased proteomic approach, we demonstrate that HGAL may interact with multiple cytoskeletal proteins thereby implicating a multiplicity of effects in regulating lymphoma motility and spread. Specifically, we show that HGAL interacts with tubulin, and this interaction may also contribute to HGAL effects on cell motility. These findings recapitulate previous observations in humans, establish the role of HGAL in dissemination of lymphoma in vivo, and explain improved survival of patients with HGAL-expressing lymphomas.
CombiFlow: combinatorial AML-specific plasma membrane expression profiles allow longitudinal tracking of clones
Authors: Houtsma Roos , van der Meer Nisha K. , Meijer Kees , Morsink Linde M. , Hogeling Shanna M. , Woolthuis Carolien M. , Ammatuna Emanuele , Nijk Marije T. , de Boer Bauke , Huls Gerwin , Mulder André B. , Schuringa Jan Jacob 
Published: September 2021

Abstract
Acute myeloid leukemia (AML) often presents as an oligoclonal disease whereby multiple genetically distinct subclones can coexist within patients. Differences in signaling and drug sensitivity of such subclones complicate treatment and warrant tools to identify them and track disease progression. We previously identified &gt;50 AML-specific plasma membrane (PM) proteins, and 7 of these (CD82, CD97, FLT3, IL1RAP, TIM3, CD25, and CD123) were implemented in routine diagnostics in patients with AML (n = 256) and myelodysplastic syndrome (n = 33). We developed a pipeline termed CombiFlow in which expression data of multiple PM markers is merged, allowing a principal component–based analysis to identify distinctive marker expression profiles and to generate single-cell t-distributed stochastic neighbor embedding landscapes to longitudinally track clonal evolution. Positivity for one or more of the markers after 2 courses of intensive chemotherapy predicted a shorter relapse-free survival, supporting a role for these markers in measurable residual disease (MRD) detection. CombiFlow also allowed the tracking of clonal evolution in paired diagnosis and relapse samples. Extending the panel to 36 AML-specific markers further refined the CombiFlow pipeline. In conclusion, CombiFlow provides a valuable tool in the diagnosis, MRD detection, clonal tracking, and understanding of clonal heterogeneity in AML.
Investigation into the Independent Metering Control Performance of a Twin Spools Valve with Switching Technology-controlled Pilot Stage
Authors: Zhong Qi , Bao Huiming , Li Yanbiao , Hong Haocen , Zhang Bin , Yang Huayong 
Published: September 2021

AbstractIn hydraulic area, independent metering control (IMC) technology is an effective approach to improve system efficiency and control flexibility. In addition, digital hydraulic technology (DHT) has been verified as a reasonable method to optimize system dynamic performance. Integrating these two technologies into one component can combine their advantages together. However, few works focused on it. In this paper, a twin spools valve with switching technology-controlled pilot stage (TSVSP) is presented, which applied DHT into its pilot stage while appending IMC into its main stage. Based on this prototype valve, a series of numerical and experiment analysis of its IMC performance with both simulated load and excavator boom cylinder are carried out. Results showed fast and robust performance of pressure and flow compound control with acceptable fluctuation phenomenon caused by switching technology. Rising time of flow response in excavator cylinder can be controlled within 200 ms, meanwhile, the recovery time of rod chamber pressure under suddenly changed condition is optimized within 250 ms. IMC system based on TSVSP can improve both dynamic performance and robust characteristics of the target actuator so it is practical in valve-cylinder system and can be applied in mobile machineries.
Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing
Authors: Zhang Tongtong , Li Qian , Li Xiaoqing , Kang Li , Jiang Yunliang , Sun Yi 
Published: September 2021

Abstract
Background
As one of “γδ-high” species, chicken is an excellent model for the study of γδ T cells in non-mammalian animals. However, a comprehensive characterization of the TCRγδ repertoire is still missing in chicken. The objective of this study was to characterize the expressed TCRγ repertoire in chicken thymus using high-throughput sequencing.

Methods
In this study, we first obtained the detailed genomic organization of the TCRγ locus of chicken based on the latest assembly of the red jungle fowl genome sequences (GRCg6a) and then characterized the TCRγ repertoire in the thymus of four chickens by using 5′ Rapid Amplification of cDNA Ends (5′ RACE) along with high-throughput sequencing (HTS).

Results
The chicken TCRγ locus contains a single Cγ gene, three functional Jγ segments and 44 Vγ segments that could be classified into six subgroups, each containing six, nineteen, nine, four, three and three members. Dot-plot analysis of the chicken TCRγ locus against itself showed that almost all the entire zone containing Vγ segments had arisen through tandem duplication events, and the main homology unit, containing 9 or 10 Vγ gene segments, has tandemly duplicated for four times. For the analysis of chicken TCRγ repertoire, more than 100,000 unique Vγ-region nucleotide sequences were obtained from the thymus of each chicken. After alignment to the germline Vγ and Jγ segments identified above, we found that the four chickens had similar repertoire profile of TCRγ. In brief, four Vγ segments (including Vγ3.7, Vγ2.13, Vγ1.6 and Vγ1.3) and six Vγ-Jγ pairs (including Vγ3.7-Jγ3, Vγ2.13-Jγ1, Vγ2.13-Jγ3, Vγ1.6-Jγ3, Vγ3.7-Jγ1 and Vγ1.6-Jγ1) were preferentially utilized by all four individuals, and vast majority of the unique CDR3γ sequences encoded 4 to 22 amino acids with mean 12.90 amino acids, which exhibits a wider length distribution and/or a longer mean length than CDR3γ of human, mice and other animal species.

Conclusions
In this study, we present the first in-depth characterization of the TCRγ repertoire in chicken thymus. We believe that these data will facilitate the studies of adaptive immunology in birds.
The burden of neck pain in Brazil: estimates from the global burden of disease study 2019
Authors: de Melo Castro Deligne Lucas , Rocha Maria Clara Brant , Malta Deborah Carvalho , Naghavi Mohsen , de Azeredo Passos Valéria Maria 
Published: September 2021

Abstract
Background
This study analyzed neck pain estimates in Brazil and its states between 2000 and 2019, in view of the country’s lacking epidemiological data.

Methods
An analysis was performed of the GBD 2019 estimates by location, sex, and age, per 100,000 population, with uncertainty intervals (95% UI). Brazilian estimates were compared to global, Mexican, English, and American rates.

Results
Global, Brazilian, and Mexican prevalence numbers were statistically homogeneous and stable in the period. Throughout the period analyzed in the study, Brazilian neck pain prevalence (2241.9; 95%UI 1770.5–2870.6) did not show statistical differences when compared to global (2696.5; 95%UI 2177.0–3375.2) or Mexican (1595.9; 95%UI 1258.9–2058.8) estimates. Estimates observed in the USA (5123.29; 95%UI 4268.35–6170.35) and England (4612.5; 95%UI 3668.8–5830.3) were significantly higher. In 2019, when compared to the USA and England, age-standardized prevalences were lower globally, in Brazil, and in Mexico. Prevalences in Brazilian states were similar, being that Roraima (1915.9; 95%UI 1506.5–2443.1) and the Federal District (1932.05; 95%UI 1515.1–2462.7) presented the lowest and highest values respectively. The exception was the state of São Paulo (3326.5; 95%UI 2609.6–4275.5). There was no statistical difference by sex, but the prevalence tended to increase with aging. In 2019, the Brazilian prevalence was 2478.6 (95% UI 1791.0–3503.8), 5017.2 (95%UI 3257.26–7483.8), and 4293.4 (95% UI 2898,8–6343.9), for those aged 15 to 49, 50 to 69, and 70+ years. There was no statistical difference among the YLDs in all locations and times.

Conclusions
Brazil is going through a fast-paced process of populational aging; a higher prevalence of neck pain in middle-aged individuals and the elderly highlights the need for lifelong prevention initiatives. The higher rates observed among higher-income populations and the homogeneity of the Brazilian estimates suggest a lack of robust epidemiological data in lower-income countries.
Femoral neck fracture combined with anterior dislocation of the femoral head: injury mechanism and proposed novel classification
Authors: Liu Jichao , Li Zhengwei , Ding Jie , Huang Bingzhe , Piao Chengdong 
Published: September 2021

AbstractBackgroundFemoral neck fracture combined with anterior dislocation of the femoral head is very rare. To our knowledge, there is no classification system yet for this rare form of injury, and the injury mechanism of femoral neck fracture combined with obturator head dislocation has not been described in the literature. In this study, we systematically reviewed the literature and the cases treated in our hospital, and identified and classified all injury types according to the injury mechanism of femoral neck fracture combined with anterior dislocation of the femoral head. Further, based on the experience of treating a patient with femoral neck fracture and obturator dislocation of the femoral head, a theoretical hypothesis was proposed for the injury mechanism of this rare type of injury.MethodsA comprehensive search was conducted on PubMed, WOS, CNKI database. These fractures were classified according to the dislocation site and injury mechanism (one injury or two injuries).Results1891 articles were initially identified through PubMed and other databases, and after bibliographic research, study screening, and removing duplicates, 1455 articles were selected. After applying the exclusion criteria, a total of 18 full-text articles describing femoral neck fractures combined with anterior dislocation of the femoral head. Different dislocation sites have different injury mechanisms. Our classification system, to the best of the authors’ knowledge, allowed us to include all types of femoral neck fractures combined with anterior dislocation of the femoral head from the literature. According to the proposed classification system, the morphological features of femoral neck fracture combined with anterior dislocation of the femoral head can be accurately conveyed between doctors.ConclusionsAll injury patterns can likely be identified using the proposed classification system. This can help avoid confusion in the nomenclature of femoral neck fractures combined with anterior dislocation of the femoral head and help surgeons to more accurately detect lesions, thereby guiding surgical treatment.
A predictive nomogram: a cross-sectional study on a simple-to-use model for screening 12-year-old children for severe caries in middle schools
Authors: Duan Shaoying , Li Meng , Zhao Jialiang , Yang Huiyu , He Jinfeng , Lei Lei , Cheng Ran , Hu Tao 
Published: September 2021

Abstract
Background
A nomogram is a tool that transforms complex regression equations into simple and visual graphs and enables clinicians and patients to conveniently compute output probabilities without needing medical knowledge and complex formulas. The aim of this study was to develop and validate a predictive nomogram to screen for severe caries among 12-year-old children based on risk factors in Sichuan Province, China.

Methods
A cross-sectional study of 4573 12-year-olds was conducted up to May 2016 in middle schools from three districts and three counties in Sichuan Province, China. All the children underwent oral examinations and completed questionnaires to assess general information, oral impacts on daily performance, dietary habits, subjective health conditions, history of dental trauma, frequency of toothache, dental visits, and knowledge, attitudes, and behaviours toward oral hygiene. Univariate analysis and multivariate logistic regression analysis were used to determine which variables were significantly associated with severe caries (operationalized as DMFT ≥ 3). A nomogram was developed and validated by using the ‘rms’ package and two cross-validation methods.

Results
Severe caries was found in 537 of the 4573 children (11.74%). Multivariate logistic regression analysis revealed that the following variables predicted a higher risk of severe caries: ‘female’ [odds ratio (OR) = 1.985, 95% confidence interval (95% CI): 1.63–2.411], ‘urban’ (OR = 2.389, 95% CI: 1.96–2.91), ‘non-only child’ (OR = 1.317, 95% CI: 1.07–1.625), ‘very poor self-assessment of oral health status’ (OR = 2.157, 95% CI: 1.34–3.467) and ‘visited a dentist less than 6 months’ (OR = 1.861, 95% CI: 1.38–2.505). Multivariate logistic regression analysis also indicated that the following variables predicted a lower risk of severe caries: ‘middle level of urbanization’ (OR = 0.395, 95% CI: 0.32–0.495) and ‘high level of urbanization’ (OR = 0.466, 95% CI: 0.37–0.596). Both the fivefold and leave-one-out cross-validation methods indicated that the nomogram model built by these 6 variables displayed good disease recognition ability.

Conclusions
The nomogram was a simple-to-use model to screen children for severe caries. This model was found to facilitate non-dental professionals in assessing risk values without oral examinations and making referrals to dental professionals.