bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responses of Biogenic Sulfur Compound Concentrations to Dust Aerosol Enrichment and Ocean Acidification in the Western Pacific Ocean
Authors: Gao Xu‐Xu , Zhang Hong‐Hai , Mao Shi‐Hai , Yang Gui‐Peng 
Published: November 2021

AbstractDeck incubation experiments were conducted to investigate how the addition of atmospheric dust aerosols and ocean acidification (OA) affects phytoplankton growth and the production of dimethylsulfide (DMS), its precursor dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO) in the oligotrophic western Pacific Ocean. The incubation experiment showed that the deposition of simulated dust aerosols greatly influenced phytoplankton growth and the release of biogenic sulfur compounds (BSCs). Furthermore, it altered the N:P ratios in seawater and phytoplankton community composition, elevating the proportions of strong DMSP and DMSO producers (mainly haptophytes). The average Chl‐a and DMS/P/O concentrations in the acidified treatment (pH 7.9) were 86.76%, 82.53%, 84.17%, and 231.06% higher than in the control. The results indicated that lower pH promoted the growth of diatoms and to a certain extent, the release of the three BSCs.
Stratospheric Temperature and Ozone Anomalies Associated With the 2020 Australian New Year Fires
Authors: Rieger L. A. , Randel W. J. , Bourassa A. E. , Solomon S. 
Published: November 2021

AbstractStratospheric aerosol, temperature, and ozone anomalies after the 2020 Australian bushfires are documented from satellite observations. Aerosol extinction is enhanced in the Southern Hemisphere (SH) lower stratosphere (LS) in early 2020, comparable in magnitude to the Calbuco eruption in 2015. Warm temperature anomalies of 1–2 K occur in the SH LS during January‐April 2020 and are coincident with enhanced aerosols. Radiative heating is indicated through anomalous temperature correlations between lower and higher latitudes. LS ozone shows midlatitude decreases several months after the aerosol maximum and before the polar vortex breakup, reaching extreme minima over the available OMPS record since 2011. Antarctic ozone depletion in the LS in 2020 reached a decadal low for both magnitude and persistence during November‐December, along with record low polar temperatures and a strong polar vortex. Overall, the polar ozone depletion, temperature, and polar vortex evolution broadly resembled the effects of the Calbuco eruption in 2015.
Midlatitude Error Growth in Atmospheric GCMs: The Role of Eddy Growth Rate
Authors: Sheshadri Aditi , Borrus Marshall , Yoder Mark , Robinson Thomas 
Published: November 2021

AbstractSeveral studies have established that atmospheric flows have a finite range of predictability, which may be reasonably considered a consequence of the underlying dynamics. In the midlatitudes, error growth is predominantly associated with baroclinic disturbances. We consider midlatitude error growth in two models: an idealized dry dynamical core and a comprehensive atmospheric general circulation model (GCM). By systematically varying equator to pole temperature gradients in the dynamical core, we show that with increasing Eady growth rates, the time elapsed before errors saturate decreases, shortening the window in which weather predictions may be useful. We also consider the limits of midlatitude predictability in the comprehensive moist GCM in a range of climates. Our results show that the times to error saturation are shorter in warmer climates than colder climates, suggesting that warmer climates are inherently less predictable.
Potential Seasonal Predictability of the Risk of Local Rainfall Extremes Estimated Using High‐Resolution Large Ensemble Simulations
Authors: Imada Y. , Kawase H. 
Published: November 2021

AbstractSignificant progress has been made in seasonal climate predictions based on general circulation models (GCMs). However, seasonal prediction of local heavy rain remains challenging due to limited resolution. A small signal‐to‐noise ratio also prevents meaningful predictions. In this study, 100‐member large‐ensemble sets of GCM simulations and high‐resolution downscaled products with a regional climate model were used to identify the unknown source of seasonal predictability for the risk of local heavy rainfall around Japan and Taiwan. The detected predictable signals depended on the location and the season. Highly predictable signals were found for events caused by typhoons and the stationary front. Further analyses of the large‐scale backgrounds simulated by the parent‐GCM revealed that each source of predictability comes from various flavors of El Niño/Southern Oscillation and anomalies in the Indian Ocean. The approach of this study potentially provides an opportunity to identify unknown predictable regional signals all over the world.
Improving Ground Heat Flux Estimation: Considering the Effect of Freeze/Thaw Process on the Seasonally Frozen Ground
Authors: Wang Jingyuan , Luo Siqiong , Lv Zhibang , Li Wenjing , Tan Xiaoqing , Dong Qingxue , Chen Zihang 
Published: November 2021

AbstractAn inadequate understanding of the changes in water and heat of the soil is likely a potential reason for the nonclosure of the surface energy balance. During the freeze/thaw period, the large volumetric heat capacity of ice and the latent heat of soil ice phase change had a specific influence on the estimation of ground heat flux (G0). However, the effects of the freeze/thaw process on G0 estimation were not well quantified using field observations. The improvements of G0 estimation by adding the soil ice heat storage (Δsice) and the latent heat of soil ice phase change (ΔsLH) were evaluated during the freeze/thaw period at two sites (Madoi and Maqu) on the eastern Tibetan Plateau. During the freeze/thaw period, both Δsice and ΔsLH had important influences on the reasonable determination of G0. Adding ΔsLH increased G0 at the daytime peak by 34.4 W/m2 (Madoi) and 9.3 W/m2 (Maqu). During the completely frozen stage, the contributions of Δsice to G0 ice + LH (adding both Δsice and ΔsLH) were higher than those during other freeze/thaw stages at both sites, and ΔsLH also made a significant contribution to G0 ice + LH. Therefore, the daily freeze/thaw cycles cannot be ignored during the completely frozen stage in the estimation of G0. The G0 ice + LH approach improved the G0 estimation more than G0 ice (adding Δsice) approach during the freezing and thawing stages. The improvements of G0 estimations increased the energy closure status and reduced the daily average of imbalance.
Trans-tail regulation-mediated suppression of cryptic transcription
Authors: Choi Jungmin , Ryoo Zae Young , Cho Dong-Hyung , Lee Hyun-Shik , Ryu Hong-Yeoul 
Published: November 2021

AbstractCrosstalk between post-translational modifications of histone proteins influences the regulation of chromatin structure and gene expression. Among such crosstalk pathways, the best-characterized example is H2B monoubiquitination-mediated H3K4 and H3K79 methylation, which is referred to as trans-tail regulation. Although many studies have investigated the fragmentary effects of this pathway on silencing and transcription, its ultimate contribution to transcriptional control has remained unclear. Recent advances in molecular techniques and genomics have, however, revealed that the trans-tail crosstalk is linked to a more diverse cascade of histone modifications and has various functions in cotranscriptional processes. Furthermore, H2B monoubiquitination sequentially facilitates H3K4 dimethylation and histone sumoylation, thereby providing a binding platform for recruiting Set3 complex proteins, including two histone deacetylases, to restrict cryptic transcription from gene bodies. The removal of both ubiquitin and SUMO, small ubiquitin-like modifier, modifications from histones also facilitates a change in the phosphorylation pattern of the RNA polymerase II C-terminal domain that is required for subsequent transcriptional elongation. Therefore, this review describes recent findings regarding trans-tail regulation-driven processes to elaborate on their contribution to maintaining transcriptional fidelity.
LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer
Authors: Zhu Bowen , Finch-Edmondson Megan , Leong Kim Whye , Zhang Xiaoqian , V. Mitheera , Lin Quy Xiao Xuan , Lee Yaelim , Ng Wei Ting , Guo Huili , Wan Yue , Sudol Marius , DasGupta Ramanuj 
Published: November 2021

AbstractLong non-coding RNAs (lncRNAs) regulate numerous biological processes involved in both development and carcinogenesis. Hippo-YAP/TAZ signaling, a critical pathway responsible for organ size control, is often dysregulated in a variety of cancers. However, the nature and function of YAP/TAZ-regulated lncRNAs during tumorigenesis remain largely unexplored. By profiling YAP/TAZ-regulated lncRNAs, we identified SFTA1P as a novel transcriptional target and a positive feedback regulator of YAP/TAZ signaling. Using non-small cell lung cancer (NSCLC) cell lines, we show that SFTA1P is transcriptionally activated by YAP/TAZ in a TEAD-dependent manner. Functionally, knockdown of SFTA1P in NSCLC cell lines inhibited proliferation, induced programmed cell death, and compromised their tumorigenic potential. Mechanistically, SFTA1P knockdown decreased TAZ protein abundance and consequently, the expression of YAP/TAZ transcriptional targets. We provide evidence that this phenomenon could potentially be mediated via its interaction with TAZ mRNA to regulate TAZ translation. Our results reveal SFTA1P as a positive feedback regulator of Hippo-YAP/TAZ signaling, which may serve as the molecular basis for lncRNA-based therapies against YAP/TAZ-driven cancers.
Recurrent de novo pathogenic variant of WASF1 in a Japanese patient with neurodevelopmental disorder with absent language and variable seizures
Authors: Shimojima Yamamoto Keiko , Yanagishita Tomoe , Yamamoto Hisako , Miyamoto Yusaku , Nagata Miho , Ishihara Yasuki , Miyashita Yohei , Asano Yoshihiro , Sakata Yasushi , Yamamoto Toshiyuki 
Published: November 2021

AbstractA recurrent de novo pathogenic variant of WASF1, NM_003931:c.1516C>T [p.Arg506*], was identified in a 6-year-old female Japanese patient with severe developmental delay, hypotonia, hyperkinetic behavior, and distinctive facial features. The initial report of five adult patients with WASF1 variants was the only previous report regarding variants of this gene; this is the second such report, reaffirming that rare but recurrent truncating variants of WASF1 are associated with severe neurodevelopmental disorders.
Representation and participation across 20 years of plant genome sequencing
Authors: Marks Rose A. , Hotaling Scott , Frandsen Paul B. , VanBuren Robert 
Published: November 2021

AbstractThe field of plant genome sequencing has grown rapidly in the past 20 years, leading to increases in the quantity and quality of publicly available genomic resources. The growing wealth of genomic data from an increasingly diverse set of taxa provides unprecedented potential to better understand the genome biology and evolution of land plants. Here we provide a contemporary view of land plant genomics, including analyses on assembly quality, taxonomic distribution of sequenced species and national participation. We show that assembly quality has increased dramatically in recent years, that substantial taxonomic gaps exist and that the field has been dominated by affluent nations in the Global North and China, despite a wide geographic distribution of study species. We identify numerous disconnects between the native range of focal species and the national affiliation of the researchers studying them, which we argue are rooted in colonialism—both past and present. Luckily, falling sequencing costs, widening availability of analytical tools and an increasingly connected scientific community provide key opportunities to improve existing assemblies, fill sampling gaps and empower a more global plant genomics community.
Unraveling energy and charge transfer in type-II van der Waals heterostructures
Authors: Liu Junyi , Li Zi , Zhang Xu , Lu Gang 
Published: November 2021

AbstractRecent experiments observed significant energy transfer in type-II van der Waals (vdW) heterostructures, such as WS2/MoSe2, which is surprising due to their staggered band alignment and weak spectral overlap. In this work, we carry out first-principles calculations to shed light on energy and charge transfer in WS2/MoSe2 heterostructure. Incorporating excitonic effect in nonadiabatic electronic dynamics, our first-principles calculations uncover a two-step process in competing energy and charge transfer, unravel their relative efficiencies and explore the means to control their competition. While both Dexter and Förster mechanisms can be responsible for energy transfer, they are shown to operate at different conditions. The excitonic effect is revealed to drive ultrafast energy and charge transfer in type-II WS2/MoSe2 heterostructure. Our work provides a comprehensive picture of exciton dynamics in vdW heterostructures and paves the way for rational design of novel vdW heterostructures for optoelectronic and photovoltaic applications.
Electrochemical tomography as a nondestructive technique to study localized corrosion of metals
Authors: van Ede M. C. , Earls C. J. , Fichtner A. , Angst U. 
Published: November 2021

AbstractWe present an approach, termed electrochemical tomography (ECT), for the in-situ study of corrosion phenomena in general, and for the quantification of the instantaneous rate of localized corrosion in particular. Traditional electrochemical techniques have limited accuracy in determining the corrosion rate when applied to localized corrosion, especially for metals embedded in opaque, porous media. One major limitation is the generally unknown anodic surface area. ECT overcomes these limitations by combining a numerical forward model, describing the electrical potential field in the porous medium, with electrochemical measurements taken at the surface, and using a stochastic inverse method to determine the corrosion rate, and the location and size of the anodic site. Additionally, ECT yields insight into parameters such as the exchange current densities, and it enables the quantification of the uncertainty of the obtained solution. We illustrate the application of ECT for the example of localized corrosion of steel in concrete.
Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
Authors: Keleta Yacob , Ramelow Julian , Cui Liwang , Li Jun 
Published: November 2021

AbstractDespite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages has been challenging. Therefore, malaria elimination strategies advocate integrated measures, including transmission-blocking approaches. Designing an effective transmission-blocking strategy relies on a sophisticated understanding of the molecular mechanisms governing the interactions between the mosquito midgut molecules and the malaria parasite. Here we review recent advances in the biology of malaria transmission, focusing on molecular interactions between Plasmodium and Anopheles mosquito midgut proteins. We provide an overview of parasite and mosquito proteins that are either targets for drugs currently in clinical trials or candidates of promising transmission-blocking vaccines.
Noncentral forces mediated between two inclusions in a bath of active Brownian rods
Authors: Sebtosheikh Mahmoud , Naji Ali 
Published: November 2021

AbstractUsing Brownian Dynamics simulations, we study effective interactions mediated between two identical and impermeable disks (inclusions) immersed in a bath of identical, active (self-propelled), Brownian rods in two spatial dimensions, by assuming that the self-propulsion axis of the rods may generally deviate from their longitudinal axis. When the self-propulsion is transverse (perpendicular to the rod axis), the accumulation of active rods around the inclusions is significantly enhanced, causing a more expansive steric layering (ring formation) of the rods around the inclusions, as compared with the reference case of longitudinally self-propelling rods. As a result, the transversally self-propelling rods also mediate a significantly longer ranged effective interaction between the inclusions. The bath-mediated interaction arises due to the overlaps between the active-rod rings formed around the inclusions, as they are brought into small separations. When the self-propulsion axis is tilted relative to the rod axis, we find an asymmetric imbalance of active-rod accumulation around the inclusion dimer. This leads to a noncentral interaction, featuring an anti-parallel pair of transverse force components and, hence, a bath-mediated torque on the dimer.
Multi-physics coupling simulation of electrode induction melting gas atomization for advanced titanium alloys powder preparation
Authors: Li Hailin , Shen Yongpeng , Liu Pu , Liang Weihua , Wang Mingjie , Wang Shuhong 
Published: November 2021

AbstractA numerical modeling method is proposed for the melting process of Titanium metals of Titanium alloys powder preparation used for 3D printing. The melting process simulation, which involves the tight coupling between electromagnetic field, thermal field and fluid flow as well as deformation associated during the melting process, is conducted by adopting the finite element method. A two-way coupling strategy is used to include the interactions between these fields by incorporating the material properties dependent on temperature and the coupling terms. In addition, heat radiation and phase change are also considered in this paper. The arbitrary Lagrangian–Eulerian formulation is exploited to model the deformation of Titanium metal during the melting process. The distribution of electromagnetic flux density, eddy current density, temperature, and fluid flow velocity at different time can be determined by utilizing this numerical method. In a word, the method proposed in this paper provides a general way to predict the melting process of electrode induction melting gas atomization (EIGA) dynamically, and it also could be used as a reference for the design and optimization of EIGA.
Tracking induced forgetting across both strong and weak memory representations to test competing theories of forgetting
Authors: Maxcey Ashleigh M. , Joykutty Zara , Megla Emma 
Published: November 2021

AbstractHere we employ a novel analysis to address the question: what causes induced forgetting of pictures? We use baseline memorability as a measure of initial memory strength to ask whether induced forgetting is due to (1) recognition practice damaging the association between the memory representation and the category cue used to activate the representation, (2) the updating of a memory trace by incorporating information about a memory probe presented during recognition practice to the stored trace, (3) inhibitory mechanisms used to resolve the conflict created when correctly selecting the practiced item activates competing exemplars, (4) a global matching model in which repeating some items will hurt memory for other items, or (5) falling into the zone of destruction, where a moderate amount of activation leads to the highest degree of forgetting. None of the accounts of forgetting tested here can comprehensively account for both the novel analyses reported here and previous data using the induced forgetting paradigm. We discuss aspects of forgetting theories that are consistent with the novel analyses and existing data, a potential solution for existing models, proposals for future directions, and considerations when incorporating memorability into models of memory.
Dynamical efficiency for multimodal time-varying transportation networks
Authors: Bellocchi Leonardo , Latora Vito , Geroliminis Nikolas 
Published: November 2021

AbstractSpatial systems that experience congestion can be modeled as weighted networks whose weights dynamically change over time with the redistribution of flows. This is particularly true for urban transportation networks. The aim of this work is to find appropriate network measures that are able to detect critical zones for traffic congestion and bottlenecks in a transportation system. We propose for both single and multi-layered networks a path-based measure, called dynamical efficiency, which computes the travel time differences under congested and free-flow conditions. The dynamical efficiency quantifies the reachability of a location embedded in the whole urban traffic condition, in lieu of a myopic description based on the average speed of single road segments. In this way, we are able to detect the formation of congestion seeds and visualize their evolution in time as well-defined clusters. Moreover, the extension to multilayer networks allows us to introduce a novel measure of centrality, which estimates the expected usage of inter-modal junctions between two different transportation means. Finally, we define the so-called dilemma factor in terms of number of alternatives that an interconnected transportation system offers to the travelers in exchange for a small increase in travel time. We find macroscopic relations between the percentage of extra-time, number of alternatives and level of congestion, useful to quantify the richness of trip choices that a city offers. As an illustrative example, we show how our methods work to study the real network of a megacity with probe traffic data.
Epicardial adipose tissue radiodensity is associated with all-cause mortality in patients undergoing hemodialysis
Authors: Kwon Seong Soon , Choi Kyoungjin , Da Nam Bo , Lee Haekyung , Cho Nam-Jun , Park Byoung Won , Kim Hyoungnae , Noh Hyunjin , Jeon Jin Seok , Han Dong Cheol , Oh Sujeong , Kwon Soon Hyo 
Published: November 2021

AbstractThe radiodensity and volume of epicardial adipose tissue (EAT) on computed tomography angiography (CTA) may provide information regarding cardiovascular risk and long-term outcomes. EAT volume is associated with mortality in patients undergoing incident hemodialysis. However, the relationship between EAT radiodensity/volume and all-cause mortality in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis remains elusive. In this retrospective study, EAT radiodensity (in Hounsfield units) and volume (in cm3) on coronary CTA were quantified for patients with ESRD using automatic, quantitative measurement software between January 2012 and December 2018. All-cause mortality data (up to December 2019) were obtained from the Korean National Statistical Office. The prognostic values of EAT radiodensity and volume for predicting long-term mortality were assessed using multivariable Cox regression models, which were adjusted for potential confounders. A total of 221 patients (mean age: 64.88 ± 11.09 years; 114 women and 107 men) with ESRD were included. The median follow-up duration (interquartile range) after coronary CTA was 29.63 (range 16.67–44.7) months. During follow-up, 82 (37.1%) deaths occurred. In the multivariable analysis, EAT radiodensity (hazard ratio [HR] 1.055; 95% confidence interval [CI] 1.015–1.095; p = 0.006) was an independent predictor of all-cause mortality in patients with ESRD. However, EAT volume was not associated with mortality. Higher EAT radiodensity on CTA is associated with higher long-term all-cause mortality in patients undergoing prevalent hemodialysis, highlighting its potential as a prognostic imaging biomarker in patients undergoing hemodialysis.