bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal echocardiographic assessment of myocardial dysfunction for arrhythmic risk stratification in phospholamban mutation carriers
Authors: Taha Karim , Verstraelen Tom E , de Brouwer Remco , de Bruin-Bon Rianne H A C M , Cramer Maarten J , Te Rijdt Wouter P , Bouma Berto J , de Boer Rudolf A , Doevendans Pieter A , Asselbergs Folkert W , Wilde Arthur A M , van den Berg Maarten P , Teske Arco J 
Published: August 2021

Abstract

Aims
Phospholamban (PLN) p.Arg14del mutation carriers are at risk of developing malignant ventricular arrhythmias (VAs) and/or heart failure. Currently, left ventricular ejection fraction (LVEF) plays an important role in risk assessment for VA in these individuals. We aimed to study the incremental prognostic value of left ventricular mechanical dispersion (LVMD) by echocardiographic deformation imaging for prediction of sustained VA in PLN p.Arg14del mutation carriers.

Methods and results
We included 243 PLN p.Arg14del mutation carriers, which were classified into three groups according to the ‘45/45’ rule: (i) normal left ventricular (LV) function, defined as preserved LVEF ≥45% with normal LVMD ≤45 ms (n = 139), (ii) mechanical LV dysfunction, defined as preserved LVEF ≥45% with abnormal LVMD &gt;45 ms (n = 63), and (iii) overt LV dysfunction, defined as reduced LVEF &lt;45% (n = 41). During a median follow-up of 3.3 (interquartile range 1.8–6.0) years, sustained VA occurred in 35 individuals. The negative predictive value of having normal LV function at baseline was 99% [95% confidence interval (CI): 92–100%] for developing sustained VA. The positive predictive value of mechanical LV dysfunction was 20% (95% CI: 15–27%). Mechanical LV dysfunction was an independent predictor of sustained VA in multivariable analysis [hazard ratio adjusted for VA history: 20.48 (95% CI: 2.57–162.84)].

Conclusion
LVMD has incremental prognostic value on top of LVEF in PLN p.Arg14del mutation carriers, particularly in those with preserved LVEF. The ‘45/45’ rule is a practical approach to echocardiographic risk stratification in this challenging group of patients. This approach may also have added value in other diseases where LVEF deterioration is a relative late marker of myocardial dysfunction.
Endovascular entry closure of a late type A aortic dissection after implantation of a self-expanding transcatheter heart valve (Evolut R): a case report
Authors: Brinkmann Christina , Koeppel Thomas , Schofer Joachim 
Published: August 2021

Abstract

Background
Late Stanford type A aortic dissections (TAADs) are a very rare complication after transcatheter aortic valve implantation (TAVI). Surgery is the treatment of choice, but perioperative mortality (25%) and neurological complications (18%) remain high.

Case summary
An 85-year-old male patient presented with acute chest pain 5 months after a transfemoral Evolut R 34 mm transcatheter heart valve (THV) implantation. On multi-slice computed tomography (MSCT) a TAAD was found with a 7 mm primary entry at the supra-annular aortic edge of the THV expanding to the innominate artery without re-entry. Due to extensive comorbidities including two bypass operations in the history, the Heart Team declined surgery. Within 6 months of watchful waiting the maximal aortic diameter (MAD) increased from 57 to 62 mm. The decision was made to perform an endovascular closure of the inflow to the false lumen by implanting a 25 mm Amplatzer™ Cribriform Septal Occluder. MSCT 4 weeks after occlusion showed the false lumen almost completely filled with thrombus, MSCT 3 months later showed a MAD reduction to 55 mm with shrinkage of the false lumen.

Discussion
Presumably, the late TAAD was caused by the supra-annular edge of the Evolut-stent. Because of the extreme risk surgical repair was not an option and a stent graft would have occluded the vein grafts. This case shows that in absence of any other treatment options endovascular closure of the entry to the false lumen can be successfully performed in a TAAD after TAVI.
The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study
Authors: Newcombe Roberto T F , Gosling Rebecca C , Rammohan Vignesh , Lawford Patricia V , Hose D Rodney , Gunn Julian P , Morris Paul D 
Published: August 2021

Abstract

Aims
International guidelines mandate the use of fractional flow reserve (FFR) and/or non-hyperaemic pressure ratios to assess the physiological significance of moderate coronary artery lesions to guide revascularization decisions. However, they remain underused such that visual estimation of lesion severity continues to be the predominant decision-making tool. It would be pragmatic to have an improved understanding of the relationship between lesion morphology and haemodynamics. The aim of this study was to compute virtual FFR (vFFR) in idealized coronary artery geometries with a variety of stenosis and vessel characteristics.

Methods and results
Coronary artery geometries were modelled, based upon physiologically realistic branched arteries. Common stenosis characteristics were studied, including % narrowing, length, eccentricity, shape, number, position relative to branch, and distal (myocardial) resistance. Computational fluid dynamics modelling was used to calculate vFFRs using the VIRTUheart™ system. Percentage lesion severity had the greatest effect upon FFR. Any ≥80% diameter stenosis in two views (i.e. concentric) was physiologically significant (FFR ≤ 0.80), irrespective of length, shape, or vessel diameter. Almost all eccentric stenoses and all 50% concentric stenoses were physiologically non-significant, whilst 70% uniform concentric stenoses about 10 mm long straddled the ischaemic threshold (FFR 0.80). A low microvascular resistance (MVR) reduced FFR on average by 0.05, and a high MVR increased it by 0.03.

Conclusion
Using computational modelling, we have produced an analysis of vFFR that relates stenosis characteristics to haemodynamic significance. The strongest predictor of a positive vFFR was a concentric, ≥80% diameter stenosis. The importance of MVR was quantified. Other lesion characteristics have a limited impact.
Impact of Relative Muscle Power on Hospitalization and All-Cause Mortality in Older Adults
Authors: Losa-Reyna Jose , Alcazar Julian , Carnicero Jose , Alfaro-Acha Ana , Castillo-Gallego Carmen , Rosado-Artalejo Cristina , Rodríguez-Mañas Leocadio , Ara Ignacio , García-García Francisco José 
Published: August 2021

Abstract

Background
The purpose of this study was to evaluate the relationship of lower-limb muscle power with mortality and hospitalization.

Methods
A total of 1 928 participants from the Toledo Study for Healthy Aging were included. Muscle power was assessed with the 5-repetition sit-to-stand test and participants were classified into different groups of relative power (ie, normalized to body mass) according to sex-specific tertiles and their inability to perform the test. Mean follow-up periods for hospitalization and all-cause mortality were 3.3 and 6.3 years, respectively.

Results
Compared to the high relative muscle power group, men with low (HR [95% CI] = 2.1 [1.2–3.6]) and women with very low and low (HR [95% CI] = 4.7 [3.0–7.4] and 1.8 [1.2–2.7]) relative power had an increased age-adjusted risk of hospitalization. After adjusting for several covariates (age, physical activity, body mass index education, depression, comorbidities, disability, and handgrip strength), these effects were attenuated (men and women with very low relative power: HR [95% CI] = 1.6 [0.9–2.9] and 2.8 [1.6–4.9]). The very low relative muscle power group had also an increased all-cause mortality risk (age-adjusted) in both men and women (HR [95% CI] = 2.3 [1.4–3.9] and 2.9 [1.6–5.3]). After adjusting for all the covariates, a significantly increased mortality risk was observed only in men (HR [95% CI] = 2.1 [1.1–3.8]; women HR [95% CI] = 1.6 [0.8–3.2]), with very low levels of relative power.

Conclusions
Relative muscle power was independently and negatively associated with mortality and hospitalization in older adults. An augmented all-cause mortality risk was noted in the lowest group of relative muscle power.
Awareness of Age-Related Gains and Losses and Their Associations With Psychological Well-Being: A Longitudinal Examination
Authors: Wilton-Harding Bethany , Windsor Tim D 
Published: August 2021

Abstract

Objectives
How people experience their own aging is more strongly linked to well-being than chronological age. This study examined associations of awareness of age-related change (AARC) with between-person differences and longitudinal changes in psychological well-being (PWB). We expected that higher AARC gains would be associated with higher PWB and increases in PWB over time. Conversely, we expected higher AARC losses would be associated with lower PWB and a steeper decline in PWB over time. Furthermore, we tested the interaction of AARC gains and AARC losses to examine whether negative associations between AARC losses and PWB would be weaker among those reporting higher AARC gains.

Methods
Data were collected in 3 waves from a 12-month longitudinal study of 408 community-dwelling older adults (aged 60 and older). Multilevel growth models were used to analyze associations between AARC and a composite measure of PWB which included key components of PWB identified in self-determination theory (satisfaction and frustration of basic psychological needs), as well as vitality, and life engagement.

Results
At the between-person level, higher AARC gains and lower AARC losses was consistently associated with higher PWB. Furthermore, associations between AARC losses and lower PWB were weaker among those with higher AARC gains. There was no evidence to suggest the interplay of AARC gains and AARC losses had implications for change in PWB over time.

Discussion
Appreciation of age-related gains may buffer the impact of AARC losses on PWB. However, longitudinal studies conducted over varying macro- and micro-time scales are needed to better understand the developmental significance of AARC for later life.
0s and 1s in marine molecular research: a regional HPC perspective
Authors: Zafeiropoulos Haris , Gioti Anastasia , Ninidakis Stelios , Potirakis Antonis , Paragkamian Savvas , Angelova Nelina , Antoniou Aglaia , Danis Theodoros , Kaitetzidou Eliza , Kasapidis Panagiotis , Kristoffersen Jon Bent , Papadogiannis Vasileios , Pavloudi Christina , Ha Quoc Viet , Lagnel Jacques , Pattakos Nikos , Perantinos Giorgos , Sidirokastritis Dimitris , Vavilis Panagiotis , Kotoulas Georgios , Manousaki Tereza , Sarropoulou Elena , Tsigenopoulos Costas S , Arvanitidis Christos , Magoulas Antonios , Pafilis Evangelos 
Published: August 2021

Abstract
High-performance computing (HPC) systems have become indispensable for modern marine research, providing support to an increasing number and diversity of users. Pairing with the impetus offered by high-throughput methods to key areas such as non-model organism studies, their operation continuously evolves to meet the corresponding computational challenges. Here, we present a Tier 2 (regional) HPC facility, operating for over a decade at the Institute of Marine Biology, Biotechnology, and Aquaculture of the Hellenic Centre for Marine Research in Greece. Strategic choices made in design and upgrades aimed to strike a balance between depth (the need for a few high-memory nodes) and breadth (a number of slimmer nodes), as dictated by the idiosyncrasy of the supported research. Qualitative computational requirement analysis of the latter revealed the diversity of marine fields, methods, and approaches adopted to translate data into knowledge. In addition, hardware and software architectures, usage statistics, policy, and user management aspects of the facility are presented. Drawing upon the last decade’s experience from the different levels of operation of the Institute of Marine Biology, Biotechnology, and Aquaculture HPC facility, a number of lessons are presented; these have contributed to the facility’s future directions in light of emerging distribution technologies (e.g., containers) and Research Infrastructure evolution. In combination with detailed knowledge of the facility usage and its upcoming upgrade, future collaborations in marine research and beyond are envisioned.
Exploring the views of community pharmacists on patient feedback on their consultations
Authors: Al-Jabr Hiyam , Katangwe-Chigamba Thando , Green Juliana , Desborough James A 
Published: August 2021

Abstract

Objectives
To explore community pharmacists’ (CPs) views on patient feedback on their consultations.

Methods
The study was conducted at community pharmacies in the East of England. Pharmacists employed at a large multiple pharmacy were invited to a telephone/face-to-face interview. Interviews were audio-recorded and thematically analysed.

Key findings
Six pharmacists participated and interviews yielded four main themes. Pharmacists shared views on benefits of collecting feedback (e.g. improving their consultations), potential barriers (e.g. bias) and associated resolutions (e.g. using anonymous questionnaires). Peer feedback was also suggested.

Conclusions
Patient feedback is welcomed by CPs and perceived useful for improving their consultations.
Validation of QuEChERS Method for Estimation of Imidacloprid and its Metabolites in Cotton Flower, Pollen, Nectariferous Tissue, and Honey
Authors: Brar Pushpinder Kaur , Kang Balpreet Kaur , Rasool Rozy , Sahoo Sanjay Kumar 
Published: August 2021

Abstract

Background
Exposure of Apis mellifera to neonicotinoid insecticides is one of the factors attributed to the recent decline in A. mellifera populations resulting in economic and ecological losses due to loss of pollination services. Honeybees can get exposed to neonicotinoids like imidacloprid directly in the field at the time of application as well as during consumption of pollen and nectar from treated plants. In addition, some metabolites of imidacloprid are more toxic than the parent compound. So, the fate of imidacloprid and its metabolites in commodities to which honeybees get exposed needs to be overhauled.

Objective
To validate QuEChERS method for estimation of imidacloprid and its metabolites in cotton flower, pollen, nectariferous tissue, and honey using HPLC.

Methods
The QuEChERS method was validated in terms of selectivity, linearity, LOD, LOQ, matrix match, accuracy, and precision. The estimation of residues was done by HPLC.

Results
Recoveries of imidacloprid and its metabolites for cotton flowers, nectariferous tissue, pollen and honey samples were in the range of 80.42–99. 83%. LOQ for imidacloprid and its metabolites was 0.01 µg/g. Acceptable precision (RSD &lt; 20%) was obtained.

Conclusion
The method allows simple and fast extraction of imidacloprid and its metabolites from cotton flower, pollen, nectariferous tissue, and honey.

Highlights
An accurate, simple, and sensitive analytical method was validated for imidacloprid and its metabolites. The method was validated according to the SANTE/12682/2019 guidelines.
Testing for Trenbolone, an Anabolic Steroid, in Biological Fluids and Head Hair in a Postmortem Case
Authors: Gheddar Laurie , Pélissier Anne-Laure , Desfeux Jacques , Niort Fabrice , Raul Jean-Sébastien , Kintz Pascal 
Published: August 2021

Abstract
A 60-year-old man was found dead at home by his wife. The man was known to be a regular trainer in a fitness center and was described as a long-term user of anabolic steroids. The autopsy revealed heart failure with cardiomegaly, visceral congestion, and pulmonary edema. The local prosecutor ordered toxicological analyses but no anatomic pathology test. Initial analyses by the liquid chromatography coupled to quadrupole time-of-flight mass spectrometry system (UPLC--q-TOF-MS) system indicated the presence in femoral blood of trenbolone, an anabolic steroid. Trenbolone was quantified with a liquid chromatography system coupled with a tandem mass spectrometer in various autopsy specimens, including hair. Concentrations of trenbolone were 3.9, 3.2, 231, and lower than 0.5 ng/mL in femoral blood, cardiac blood, bile, and vitreous humor, respectively. Moreover, in head hair, the concentration was 9 pg/mg. The presence of trenbolone in hair can be interpreted as repetitive exposures when compared to the limited literature data. Repetitive misuse of trenbolone can explain advanced heart failure. This paper highlights the importance of testing biological specimens for anabolic steroids in case of heart failure.
Patient-specific template and electromagnetic navigation assisted bilateral periacetabular osteotomy for staged correction of bilateral injury-induced hip dysplasia: a case report
Authors: Brumat Peter , Mihalič Rene , Benulič Črt , Kristan Anže , Trebše Rihard 
Published: August 2021

ABSTRACT
Periacetabular osteotomy (PAO) for pelvic fracture sequelae presents a challenge in hip preservation surgery due to a combination of complex conditions involving post-traumatic altered anatomy and technically demanding procedure, with high surgical risk involved. To address these challenging conditions and evade potential devastating complications, a combination of patient-specific template (PST) and electromagnetic navigation (EMN) guidance can be used to increase the safety of the procedure and the accuracy of the acetabular reorientation. Herein we report our experience utilizing a combined PST- and EMN-assisted bilateral PAO for staged correction of bilateral severe, injury-induced hip dysplasia. The presented case report describes a unique method of successful surgical treatment of severe, bilateral injury-induced hip dysplasia with combined 3-D printing technology (PST) and intra-operative electromagnetic computer-assisted navigation (EMN) aided technically demanding surgical procedure (PAO), which emphasizes the benefits of PST and EMN use in hip preservation surgery in patients with complex pathoanatomic circumstances.
Stable Fly (Diptera: Muscidae)—Biology, Management, and Research Needs
Authors: Rochon K , Hogsette J A , Kaufman P E , Olafson P U , Swiger S L , Taylor D B 
Published: August 2021

AbstractStable flies, Stomoxys calcitrans (L.) are global pests of livestock, companion animals, and humans. These flies inflict painful bites and cause significant economic losses to producers by reducing livestock production. In addition, they have been associated with the mechanical transmission of several pathogens causing disease in animals. Management of this species is difficult because: 1) their developmental habitats are often ephemeral accumulations of decomposing vegetation, 2) they can exploit cultural practices in many agricultural and urban environments, and 3) the adults are highly mobile. An integrated pest management (IPM) approach is required to effectively manage stable flies, including integration of cultural, mechanical, physical, biological, and chemical control options. The challenges of stable flies in different animal commodities are discussed, and current and novel technologies for control are presented. Lastly, need for additional research to improve stable fly management methods are discussed.
Computational evaluation of sparse coding on off-axis electron holograms: comparison between charge-coupled device and direct-detection device cameras
Authors: Anada Satoshi , Nomura Yuki , Hirayama Tsukasa , Yamamoto Kazuo 
Published: August 2021

AbstractThe effectiveness of sparse coding for image inpainting and denoising of off-axis electron holograms was examined computationally based on hologram simulations according to considerations of two types of electron detectors, namely charge-coupled device (CCD) and direct-detection device (DDD) cameras. In this simulation, we used a simple-phase object with a phase step such as a semiconductor p–n junction and assumed that the holograms recorded by the CCD camera include shot noise, dark-current noise and read-out noise, while those recorded by the DDD camera include only shot noise. Simulated holograms with various electron doses were sparsely coded. Even though interference fringes cannot be recognized in the simulated CCD and DDD holograms when subjected to electron doses (per pixel) equal to 1 and 0.01, respectively, both the corresponding sparse-coded holograms exhibit meaningful interference fringes. We demonstrate that a combination of the DDD camera and sparse coding reduces the requisite dose used to obtain holograms to values less than one-thousandth compared with the CCD camera without image postprocessing. This combination is expected to generate lower-dose and/or higher-speed electron holography.
Trapped in the Wrong Body? Transgender Identity Claims, Body-Self Dualism, and the False Promise of Gender Reassignment Therapy
Authors: Moschella Melissa 
Published: August 2021

Abstract
In this article, I explore difficult and sensitive questions regarding the nature of transgender identity claims and the appropriate medical treatment for those suffering from gender dysphoria. I first analyze conceptions of transgender identity, highlighting the prominence of the wrong-body narrative and its dualist presuppositions. I then briefly argue that dualism is false because our bodily identity (including our body’s biological organization for sexual reproduction as male or female) is essential and intrinsic to our overall personal identity and explain why a sound, nondualist anthropology implies that gender identity cannot be entirely divorced from sexual identity. Finally, I make the case that arguments in favor of hormonal and surgical treatments for gender dysphoria rest on this mistaken dualist anthropology, and that these treatments therefore give false hope to those suffering from gender dysphoria, while causing irreversible bodily harm and diverting attention from underlying psychological problems that often need to be addressed. I also briefly discuss how these philosophical claims relate to empirical studies on the outcomes of hormonal and surgical treatments for gender dysphoria and to testimonies of transgender individuals who regret having undergone these treatments.