bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between early thiamine administration and clinical outcomes in critically ill patients with acute kidney injury
Authors: Li Xunliang , Luan Hong , Zhang Hui , Li Chenyu , Bu Quandong , Zhou Bin , Tang Nina , Zhou Haiyan , Xu Yan , Jiang Wei , Zhao Long , Man Xiaofei , Che Lin , Wang Yanfei , Luo Congjuan , Sun Jianping 
Published: August 2021

AbstractThe effects of early thiamine use on clinical outcomes in critically ill patients with acute kidney injury (AKI) are unclear. The purpose of this study was to investigate the associations between early thiamine administration and clinical outcomes in critically ill patients with AKI. The data of critically ill patients with AKI within 48 h after ICU admission were extracted from the Medical Information Mart for Intensive Care III (MIMIC III) database. PSM was used to match patients early receiving thiamine treatment to those not early receiving thiamine treatment. The association between early thiamine use and in-hospital mortality due to AKI was determined using a logistic regression model. A total of 15 066 AKI patients were eligible for study inclusion. After propensity score matching (PSM), 734 pairs of patients who did and did not receive thiamine treatment in the early stage were established. Early thiamine use was associated with lower in-hospital mortality (OR 0·65; 95 % CI 0·49, 0·87; P < 0·001) and 90-d mortality (OR 0·58; 95 % CI 0·45, 0·74; P < 0·001), and it was also associated with the recovery of renal function (OR 1·26; 95 % CI 1·17, 1·36; P < 0·001). In the subgroup analysis, early thiamine administration was associated with lower in-hospital mortality in patients with stages 1 to 2 AKI. Early thiamine use was associated with improved short-term survival in critically ill patients with AKI. It was possible beneficial role in patients with stages 1 to 2 AKI according to the Kidney Disease: Improving Global Outcomes criteria.
Dietary acid load and mortality from all causes, CVD and cancer: results from the Golestan Cohort Study
Authors: Hejazi Ehsan , Emamat Hadi , Sharafkhah Maryam , Saidpour Atoosa , Poustchi Hossein , Sepanlou Sadaf , Sotoudeh Masoud , Dawsey Sanford , Boffetta Paolo , Abnet Christian C , Kamangar Farin , Etemadi Arash , Pourshams Akram , Malekshah Akbar Fazeltabar , Berennan Paul , Malekzadeh Reza , Hekmatdoost Azita 
Published: August 2021

AbstractGiven the limited studies and controversial results on association between dietary acid load and mortality from CVD and cancers, we aimed to investigate this association in a large population cohort study in Middle East, with a wide range of dietary acid load. The study was conducted on the platform of the Golestan Cohort Study (GCS), which enrolled 50 045 participants in 2004–2008. Dietary intake was assessed using a validated FFQ. Dietary potential renal acid load (PRAL) score was calculated from nutrient intake. Death and its causes were identified and confirmed by two or three physicians. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95 % CI for total and cause-specific mortalities. Then, the associations were modelled using restricted cubic splines. PRAL range was −57·36 to +53·81 mEq/d for men and −76·70 to +49·08 for women. During 555 142 person-years of follow-up, we documented 6830 deaths, including 3070 cardiovascular deaths, 1502 cancer deaths and 2258 deaths from other causes. For overall deaths, in final model after adjustment for confounders, participants in the first and fifth quintiles of PRAL had a higher risk of mortality compared with the second quintile of PRAL (HR: 1·08; 95 % CI1·01, 1·16 and HR: 1·07; 95 % CI 1·01, 1·15, respectively); Pfor trend < 0·05). Participants in the first and fifth quintiles of PRAL had a 12 % higher risk of CVD mortality compared with the Q2 of PRAL (HR: 1·12; 95 % CI 1·01–1·25 and HR: 1·12; 95 % CI 1·01, 1·26, respectively; Pfor trend < 0·05). We found that all-cause and CVD mortality rates were higher in the lowest and highest PRAL values, in an approximately U-shaped relation (P-values for the overall association and the non-linear association of energy-adjusted PRAL with total mortality were < 0·001 and < 0·001, and with CVD mortality were 0·008 and 0·003, respectively). Our results highlight unfavourable associations of high acidity and alkalinity of diet with the increased total and CVD mortality risk. It may be important to consider a balanced acid–base diet as a protective strategy to prevent pre-mature death, especially from CVD.
Motivations and attitudes of Brazilian dairy farmers regarding the use of automated behaviour recording and analysis systems
Authors: Vieira Aline C. , Fischer Vivian , Canozzi Maria Eugênia A. , Garcia Lisiane S. , Morales-Piñeyrúa Jessica Tatiana 
Published: August 2021

AbstractIn this Research Communication we investigate the motivations of Brazilian dairy farmers to adopt automated behaviour recording and analysis systems (ABRS) and their attitudes towards the alerts that are issued. Thirty-eight farmers participated in the study distributed into two groups, ABRS users (USERS, n = 16) and non-users (NON-USERS, n = 22). In the USERS group 16 farmers accepted being interviewed, answering a semi-structured interview conducted by telephone, and the answers were transcribed and codified. In the NON-USERS group, 22 farmers answered an online questionnaire. Descriptive analysis was applied to coded answers. Most farmers were young individuals under 40 years of age, with undergraduate or graduate degrees and having recently started their productive activities, after a family succession process. Herd size varied with an overall average of approximately 100 cows. Oestrus detection and cow's health monitoring were the main reasons given to invest in this technology, and cost was the most important factor that prevented farmers from purchasing ABRS. All farmers in USERS affirmed that they observed the target cows after receiving a health or an oestrus alert. Farmers believed that they were able to intervene in the evolution of the animals' health status, as the alerts gave a window of three to four days before the onset of clinical signs of diseases, anticipating the start of the treatment.The alerts issued by the monitoring systems helped farmers to reduce the number of cows to be observed and to identify pre-clinically sick and oestrous animals more easily. Difficulties in illness detection and lack of definite protocols impaired the decision making process and early treatment, albeit farmers believed ABRS improved the farm's routine and reproductive rates.
Promoting health economic evaluation studies in the AYUSH system of medicine: the need of the hour
Authors: Muthappan Sendhilkumar , Bagepally Bhavani Shankara , Ponnaiah Manickam 
Published: August 2021

Abstract
The double burden of communicable and noncommunicable diseases is a major threat to the Indian public health system. AYUSH, an acronym for Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa-Rigpa, and Homeopathy, represents the Indian system of medicine recognized by the Government of India. Mainstreaming of AYUSH is one of the key strategies of the Indian government for tackling increasing disease burden through initiatives such as AYUSH wellness centers, telemedicine, and quality control measures for medications in the AYUSH system of medicine. Such investment of resources in health systems may require economic evaluations. However, such evaluations are lacking in the AYUSH system, except for a few in homeopathy and yoga. In the absence of evidence from economic evaluations, researchers and decision makers are guided mostly by clinical efficacy while formulating healthcare strategies. In view of the increasing use of AYUSH across the country, economic evaluations of the AYUSH system are the need of the hour to aid healthcare decision making.
An improved primal-dual approximation algorithm for the k-means problem with penalties
Authors: Ren Chunying , Xu Dachuan , Du Donglei , Li Min 
Published: August 2021

AbstractIn the k-means problem with penalties, we are given a data set $${\cal D} \subseteq \mathbb{R}^\ell $$ of n points where each point $$j \in {\cal D}$$ is associated with a penalty cost pj and an integer k. The goal is to choose a set $${\rm{C}}S \subseteq {{\cal R}^\ell }$$ with |CS| ≤ k and a penalized subset $${{\cal D}_p} \subseteq {\cal D}$$ to minimize the sum of the total squared distance from the points in D / Dp to CS and the total penalty cost of points in Dp, namely $$\sum\nolimits_{j \in {\cal D}\backslash {{\cal D}_p}} {d^2}(j,{\rm{C}}S) + \sum\nolimits_{j \in {{\cal D}_p}} {p_j}$$. We employ the primal-dual technique to give a pseudo-polynomial time algorithm with an approximation ratio of (6.357+ε) for the k-means problem with penalties, improving the previous best approximation ratio 19.849+∊ for this problem given by Feng et al. in Proceedings of FAW (2019).
Combining patient-specific, digital 3D models with tele-education for adolescents with CHD
Authors: Liddle David , Balsara Sheri , Hamann Karin , Christopher Adam , Olivieri Laura , Loke Yue-Hin 
Published: August 2021

AbstractIntroduction:Adolescents with CHD require transition to specialised adult-centred care. Previous studies have shown that adolescents’ knowledge of their medical condition is correlated with transition readiness. Three-dimensional printed models of CHD have been used to educate medical trainees and patients, although no studies have focused on adolescents with CHD. This study investigates the feasibility of combining patient-specific, digital 3D heart models with tele-education interventions to improve the medical knowledge of adolescents with CHD.Methods:Adolescent patients with CHD, aged between 13 and 18 years old, were enrolled and scheduled for a tele-education session. Patient-specific digital 3D heart models were created using images from clinically indicated cardiac magnetic resonance studies. The tele-education session was performed using commercially available, web-conferencing software (Zoom, Zoom Video Communications Inc.) and a customised software (Cardiac Review 3D, Indicated Inc.) incorporating an interactive display of the digital 3D heart model. Medical knowledge was assessed using pre- and post-session questionnaires that were scored by independent reviewers.Results:Twenty-two adolescents completed the study. The average age of patients was 16 years old (standard deviation 1.5 years) and 56% of patients identified as female. Patients had a variety of cardiac defects, including tetralogy of Fallot, transposition of great arteries, and coarctation of aorta. Post-intervention, adolescents’ medical knowledge of their cardiac defects and cardiac surgeries improved compared to pre-intervention (p < 0.01).Conclusions:Combining patient-specific, digital 3D heart models with tele-education sessions can improve adolescents’ medical knowledge and may assist with transition to adult-centred care.
Upstream and downstream explanations of the harms of ultra-processed foods in national dietary guidelines
Authors: Quinn Madalyn , Jordan Helen , Lacy-Nichols Jennifer 
Published: August 2021

AbstractObjective:Dietary advice about the potential health risks of unhealthy foods or diets has historically been communicated in terms of nutrients. Recent evidence has shown that the processing of food itself is independently attributable to harmful outcomes, particularly a new category of foods described to be ‘ultra-processed’. Dietary guidelines (DG) are a key policy tool to translate and communicate nutrition research; however, there is little research exploring whether and how the harms of food processing are communicated and rationalised in dietary advice.Design:Nineteen publicly available DG were thematically analysed to explore: (1) the diversity of terms used to refer to processed foods and (2) the underlying explanations and rationales provided to reduce consumption of processed foods.Setting:International.Participants:Sample of national dietary guidelines.Results:Seventeen different descriptive terms were used to refer to processed foods, with many countries using a large variation of terms within their DG. Six rationales to reduce consumption of processed foods were identified, which were grouped into four overarching domains: harmful outcomes (disease risk, environmental risk); food quality (food quality, nutrient content); diet quality and food environment.Conclusion:The rationales provided to reduce the consumption of processed foods reflect upstream and downstream determinants of health. However, the persistence of nutrient-based rationales indicate that most DG do not apply an upstream understanding of the issues with ultra-processing. Further, the diversity of terms and foods referenced in DG suggest that the concept of ultra-processing is subject to multiple interpretations.
Henry Allison on Kant’s First Analogy
Authors: Osborne Gregg 
Published: August 2021

AbstractHenry Allison’s interpretation of Kant’s First Analogy is among the most intriguing in the literature. Its virtues are considerable, but no previous discussion has done full justice to them. Nor has any previous discussion systematically explored the most important challenges to which it seems subject. This paper does both. Early sections provide a more thorough exegesis than is otherwise available and provide stronger textual backing than does Allison himself. Later sections turn to problems, most of which have not been raised by others. These problems, while serious, do not necessarily rule out the interpretation of Allison.
Multiband antenna design based on Gosper fractal for implantable biomedical devices
Authors: Kumar Rajeev , Singh Surinder , Singh Chauhan Ajay pal 
Published: August 2021

AbstractIn this paper, a novel multiband implantable planar inverted-F antenna (PIFA) antenna based on Gosper curve fractal geometry is designed for biomedical telemetry applications. The antenna has covered four dedicated frequency bands; medical implant communication system band (MICS 402–405 MHz), industrial, scientific, and medical bands (ISM 902–928 MHz and 2.4–2.5 GHz), and wireless medical telemetry services (WMTS 1395–1400 and 1429–1432 MHz). The proposed antenna is designed on Rogers RO 3010 substrate of thickness 25 mil and volume equal to 153.67 mm3. The reflection coefficient and the radiation pattern are measured inside muscle-mimicking liquid tissue phantom. The antenna has achieved the impedance bandwidth of 126, 406, 168, and 175 MHz at MICS (403 MHz), ISM (915 MHz), WMTS (1400 MHz), and ISM (2.45 GHz) with maximum gain value −33.6, −21.04, −15.48, and −10.25 dBi, respectively. The data link range between the implantable antenna and off body antenna has been performed with −16 dBm input power. Additionally, the obtained specific absorption rate with the input of 25 μW power has also been obtained within the safety limit and hence ensures the reliability of the proposed antenna.
Liquid Containing Clouds at the North Slope of Alaska Demonstrate Sensitivity to Local Industrial Aerosol Emissions
Authors: Maahn Maximilian , Goren Tom , Shupe Matthew D. , de Boer Gijs 
Published: August 2021

AbstractCloud condensation nucleus control alter cloud solar albedo through cloud droplet size. Here, we leverage anthropogenic emissions at the North Slope of Alaska as a natural laboratory to study relationships between aerosols and Arctic liquid‐containing clouds. Averaging 14 years of MODIS observations, we found a reduction in temporally averaged cloud effective radius () of up to 1.0 μm related to localized pollution. Pronounced regional gradients in cloud frequency of occurrence and liquid water path prohibit the detection of potential changes of these variables. Observed changes of alter radiative fluxes and increase cloud‐reflected shortwave radiation by up to 0.8 W m−2 in the Prudhoe Bay area for the period covered by observations (April–September). Due to the frequent occurrence of liquid‐containing clouds, this implies that enhanced local emissions in Arctic regions can impact climate processes.
Receiver Function Imaging of the Amphibious NE Japan Subduction Zone—Effects of Low‐Velocity Sediment Layer
Authors: Kim HyeJeong , Kawakatsu Hitoshi , Akuhara Takeshi , Shinohara Masanao , Shiobara Hajime , Sugioka Hiroko , Takagi Ryota 
Published: August 2021

AbstractThis study presents reflectivity images of the northeast (NE) Japan subduction zone continuous across the ocean and land. As nearly half of its forearc region is under the ocean, data from ocean bottom seismometers (OBSs) must be utilized to fully image the region by passive seismic analysis. The use of OBS data has been a challenge due to inherent characters of the ocean bottom observations: high noise level and effects of seafloor sediment. Now, decent imaging is possible in NE Japan overcoming the high level noise due to the accumulated data set of the OBSs. The low‐velocity of seafloor sediment significantly delays and amplifies S waves passing through them, and thus complicates teleseismic waveforms. We identify and correct these effects to produce coherent receiver function images throughout the amphibious subduction zone. Our images provide a potential for discussing new structural features and will help better understanding of the dynamics of the NE Japan subduction zone.
Melatonin as an immunomodulator in children with Down syndrome
Authors: Huggard Dean , Kelly Lynne , Worrall Amy , Gallagher Eleanor , Fallah Lida , Yoo Lucas Lu , McGrane Fiona , Lagan Niamh , Roche Edna , Balfe Joanne , Doherty Derek G. , Molloy Eleanor J. 
Published: August 2021

AbstractBackgroundDown syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, increased oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin has a myriad of immune functions, and we hypothesised that this therapeutic agent could modulate the innate immune system in this cohort.MethodsWe investigated neutrophil and monocyte function (CD11b, TLR4 expression by flow cytometry), genes involved in TLR signalling (MyD88, IRAK4, TRIF), the inflammasome (NLRP3, IL-1β), and circadian rhythm (BMAL, CLOCK, CRY) by qPCR, and inflammatory cytokines (IL-2, IL-6, IL-8, IL-18, IL-1β, TNF-α, IFN-γ, IL-10, IL-1ra, VEGF, Epo, GM-CSF) by enzyme-linked immunosorbent assay (ELISA) following immunomodulation with LPS endotoxin and melatonin. 47 children with DS and 23 age- and sex-matched controls were recruited.ResultsWe demonstrated that melatonin has several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signalling, genes involved in the inflammasome and has the potential to reduce LPS-induced inflammatory responses.ConclusionsImmunomodulatory effects of melatonin were found in both paediatric cohorts with more marked effects in the children with DS. Melatonin mediates immune response through a wide array of mechanisms and this immunomodulator may buffer the inflammatory response by regulating pro and anti-inflammatory signalling.ImpactWe highlight that melatonin mediates its immune response through a wide array of mechanisms, its effects appear to be dose dependant and children with Down syndrome may be more receptive to treatment with it.Immunomodulatory effects of melatonin were demonstrated with marked effects in the children with Down syndrome with a reduction of MyD88, IL-1ß and NLRP3 expression in whole-blood samples.Melatonin is a proposed anti-inflammatory agent with a well-established safety profile, that has the potential for mitigation of pro- and anti-inflammatory cytokines in paediatric Down syndrome cohorts, though further clinical trials are warranted.
Directed synthesis of a hybrid improper magnetoelectric multiferroic material
Authors: Zhu Tong , Orlandi Fabio , Manuel Pascal , Gibbs Alexandra S. , Zhang Weiguo , Halasyamani P. Shiv. , Hayward Michael A. 
Published: August 2021

AbstractPreparing materials which simultaneously exhibit spontaneous magnetic and electrical polarisations is challenging as the electronic features which are typically used to stabilise each of these two polarisations in materials are contradictory. Here we show that by performing low-temperature cation-exchange reactions on a hybrid improper ferroelectric material, Li2SrTa2O7, which adopts a polar structure due to a cooperative tilting of its constituent TaO6octahedra rather than an electronically driven atom displacement, a paramagnetic polar phase, MnSrTa2O7, can be prepared. On cooling below 43 K the Mn2+centres in MnSrTa2O7adopt a canted antiferromagnetic state, with a small spontaneous magnetic moment. On further cooling to 38 K there is a further transition in which the size of the ferromagnetic moment increases coincident with a decrease in magnitude of the polar distortion, consistent with a coupling between the two polarisations.
Linear reinforcement learning in planning, grid fields, and cognitive control
Authors: Piray Payam , Daw Nathaniel D. 
Published: August 2021

AbstractIt is thought that the brain’s judicious reuse of previous computation underlies our ability to plan flexibly, but also that inappropriate reuse gives rise to inflexibilities like habits and compulsion. Yet we lack a complete, realistic account of either. Building on control engineering, here we introduce a model for decision making in the brain that reuses a temporally abstracted map of future events to enable biologically-realistic, flexible choice at the expense of specific, quantifiable biases. It replaces the classic nonlinear, model-based optimization with a linear approximation that softly maximizes around (and is weakly biased toward) a default policy. This solution demonstrates connections between seemingly disparate phenomena across behavioral neuroscience, notably flexible replanning with biases and cognitive control. It also provides insight into how the brain can represent maps of long-distance contingencies stably and componentially, as in entorhinal response fields, and exploit them to guide choice even under changing goals.
Pre-meiotic 21-nucleotide reproductive phasiRNAs emerged in seed plants and diversified in flowering plants
Authors: Pokhrel Suresh , Huang Kun , Bélanger Sébastien , Zhan Junpeng , Caplan Jeffrey L. , Kramer Elena M. , Meyers Blake C. 
Published: August 2021

AbstractPlant small RNAs are important regulatory elements that fine-tune gene expression and maintain genome integrity by silencing transposons. Reproductive organs of monocots produce abundant phased, small interfering RNAs (phasiRNAs). The 21-nt reproductive phasiRNAs triggered by miR2118 are highly enriched in pre-meiotic anthers, and have been found in multiple eudicot species, in contrast with prior reports of monocot specificity. The 24-nt reproductive phasiRNAs are triggered by miR2275, and are highly enriched during meiosis in many angiosperms. Here, we report the widespread presence of the 21-nt reproductive phasiRNA pathway in eudicots including canonical and non-canonical microRNA (miRNA) triggers of this pathway. In eudicots, these 21-nt phasiRNAs are enriched in pre-meiotic stages, a spatiotemporal distribution consistent with that of monocots and suggesting a role in anther development. Although this pathway is apparently absent in well-studied eudicot families including the Brassicaceae, Solanaceae and Fabaceae, our work in eudicots supports an earlier singular finding in spruce, a gymnosperm, indicating that the pathway of 21-nt reproductive phasiRNAs emerged in seed plants and was lost in some lineages.