bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromatin accessibility combined with enhancer clusters activation mediates heterogeneous response to dexamethasone in myeloma cells
Authors: Gaborit Victor , Cruard Jonathan , Guerin-Charbonnel Catherine , Derrien Jennifer , Alberge Jean-Baptiste , Douillard Elise , Roi Nathalie , Devic Magali , Campion Loïc , Westermann Frank , Moreau Phillipe , Herrmann Carl , Bourdon Jérémie , Magrangeas Florence , Minvielle Stéphane 
Published: September 2021

AbstractGlucocorticoids (GC) effects occur through binding to the GC receptor (GR) which, once translocated to the nucleus, binds to GC response elements (GREs) to activate or repress target genes. Among GCs, dexamethasone (Dex) is widely used in treatment of multiple myeloma (MM), mainly in combination regimens. However, despite a definite benefit, all patients relapse. Moreover, while GC efficacy can be largely attributed to lymphocyte-specific apoptosis, its molecular basis remains elusive.To determine the functional role of GR binding in myeloma cells, we generated bulk and single cell multi-omic data and high-resolution contact maps of active enhancers and target genes. We show that a minority (6%) of GR binding sites are associated with enhancer activity gains and increased interaction loops. We find that enhancers contribute to regulate gene activity through combinatorial assembly of large stretches of enhancers and/or enhancer cliques. Furthermore, one enhancer, proximal to GR-responsive genes, is predominantly associated with increased chromatin accessibility and higher H3K27ac occupancy. Finally, we show that Dex exposure leads to co-accessibility changes between predominant enhancer and other regulatory regions of the interaction network. Notably, these epigenomic changes are associated with cell-to-cell transcriptional heterogeneity. As consequences, BIM critical for GR-induced apoptosis and CXCR4 protective from chemotherapy-induced apoptosis are rather upregulated in different cells.In summary, our work provides new insights into the molecular mechanisms involved in Dex escape.
The Import of Skin Tissue Dynamics in Tactile Sensing
Authors: Rongala Udaya B. , Seyfarth Andre , Hayward Vincent , Jörntell Henrik 
Published: September 2021

AbstractThe mammalian skin is a densely innervated soft tissue where embedded neural mechanoreceptors report to the brain the mechanical events arising at its surface. Up to now, models of the transformations of these events into neural signals relied on quasistatic or viscoelastic mechanical models of the skin. Here, we employed a model which, in addition to elasticity and viscosity, accounted for mass to accurately reproduce the propagation of mechanical waves observed in vivo. Skin dynamics converted sensory inputs into rapidly evolving spatiotemporal patterns that magnified the information made available to a population of mechanoreceptors. Accounting for dynamics greatly enhanced the separability of tactile inputs and was efficient for a large range of mechanical parameter values. This advantage vanished when these parameters were set to approximate the quasistatic or viscoelastic cases.
Molecular organization and mechanics of single vimentin filaments revealed by super-resolution imaging
Authors: Vicente Filipe Nunes , Lelek Mickael , Tinevez Jean-Yves , Tran Quang D. , Pehau-Arnaudet Gerard , Zimmer Christophe , Etienne-Manneville Sandrine , Giannone Gregory , Leduc Cécile 
Published: September 2021

AbstractIntermediate filaments (IF) are involved in key cellular functions including polarization, migration, and protection against large deformations. These functions are related to their remarkable ability to extend without breaking, a capacity that should be determined by the molecular organization of subunits within filaments. However, this structure-mechanics relationship remains poorly understood at the molecular level. Here, using super-resolution microscopy (SRM), we show that vimentin filaments exhibit a ~49 nm axial repeat both in cells and in vitro. As unit-length-filaments (ULFs) were measured at ~59 nm, this demonstrates a partial overlap of ULFs during filament assembly. Using an SRM-compatible stretching device, we also provide evidence that the extensibility of vimentin is due to the unfolding of its subunits and not to their sliding, thus establishing a direct link between the structural organization and its mechanical properties. Overall, our results pave the way for future studies of IF assembly, mechanical and structural properties in cells.
Accurate grasp detection learning using oriented regression loss
Authors: Zhao Xuan , Yu Hancheng , Feng Mingkui , Sun Gang 
Published: September 2021

Purpose
Robot automatic grasping has important application value in industrial applications. Recent works have explored on the performance of deep learning for robotic grasp detection. They usually use oriented anchor boxes (OABs) as detection prior and achieve better performance than previous works. However, the parameters of their loss belong to different coordinates, this may affect the regression accuracy. This paper aims to propose an oriented regression loss to solve the problem of inconsistency among the loss parameters.

Design/methodology/approach
In the oriented loss, the center coordinates errors between the ground truth grasp rectangle and the predicted grasp rectangle rotate to the vertical and horizontal of the OAB. And then the direction error is used as an orientation factor, combining with the errors of the rotated center coordinates, width and height of the predicted grasp rectangle.

Findings
The proposed oriented regression loss is evaluated on the YOLO-v3 framework to the grasp detection task. It yields state-of-the-art performance with an accuracy of 98.8% and a speed of 71 frames per second with GTX 1080Ti on Cornell datasets.

Originality/value
This paper proposes an oriented loss to improve the regression accuracy of deep learning for grasp detection. The authors apply the proposed deep grasp network to the visual servo intelligent crane. The experimental result indicates that the approach is accurate and robust enough for real-time grasping applications.
Obstacle avoidance and path planning of humanoid robot using fuzzy logic controller aided owl search algorithm in complicated workspaces
Authors: Kashyap Abhishek Kumar , Parhi Dayal R. 
Published: September 2021

Purpose
This paper aims to outline and implement a novel hybrid controller in humanoid robots to map an optimal path. The hybrid controller is designed using the Owl search algorithm (OSA) and Fuzzy logic.

Design/methodology/approach
The optimum steering angle (OS) is used to deal with the obstacle located in the workspace, which is the output of the hybrid OSA Fuzzy controller. It is obtained by feeding OSA's output, i.e. intermediate steering angle (IS), in fuzzy logic. It is obtained by supplying the distance of obstacles from all directions and target distance from the robot's present location.

Findings
The present research is based on the navigation of humanoid NAO in complicated workspaces. Therefore, various simulations are performed in a 3D simulator in different complicated workspaces. The validation of their outcomes is done using the various experiments in similar workspaces using the proposed controller. The comparison between their outcomes demonstrates an acceptable correlation. Ultimately, evaluating the proposed controller with another existing navigation approach indicates a significant improvement in performance.

Originality/value
A new framework is developed to guide humanoid NAO in complicated workspaces, which is hardly seen in the available literature. Inspection in simulation and experimental workspaces verifies the robustness of the designed navigational controller. Considering minimum error ranges and near collaboration, the findings from both frameworks are evaluated against each other in respect of specified navigational variables. Finally, concerning other present approaches, the designed controller is also examined, and major modifications in efficiency have been reported.
New Zealand’s ANZAC nurses: marketizing the great war for a 21st-century fit
Authors: Krisjanous Jayne , Hallett Christine 
Published: September 2021

PurposeThe aim of this paper is to demonstrate how a historical event packaged as an iconic heritage cultural brand can be marketized and modified over time to ensure brand longevity and continued emotional commitment and loyalty through the leverage of stories and associations more closely aligned with modern-day audiences. The authors do this through examining the marketization of the New Zealand World War 1 (WWI) nurse to today’s audiences. The periods of study are WWI (1914–1918) and then the modern day. The New Zealand Army Nursing Service (NZANS) during WWI has previously had little attention as a key actor in the Australia and New Zealand Army Corp (ANZAC), Today ANZAC is held as pivotal in the birth of New Zealand’s perception of nationhood and as an iconic heritage cultural brand. The history and legend of the ANZAC plays an important role in New Zealand culture and is fundamental to the “Anzac Spirit”, a signifier of what it means to be a New Zealander.Design/methodology/approachA historical case study method is used. The primary source of data is 1914–1918, and includes contemporaneous articles, and personal writings: diaries, letters and published memoirs. More contemporary works form the basis for discussion of marketization as it relates to the NZANS. The article first presents conceptual framing, then the development of the Anzac brand and the history of the NZANS and its role in WWI before turning to discussion on the marketization of this nursing service to today’s audiences and as part of the ANZAC/Anzac brand.FindingsToday the story of the WWI NZANS nurse, previously seldom heard, has been co-opted and is becoming increasingly merged as an integral part of the Anzac story. The history of the NZANS during WWI has a great deal of agency today as part of that story, serving many functions within it and providing a valuable lever for marketization.Originality/valueTo date, there is a scarcity of marketing analysis that examines the marketization of history. By focusing on New Zealand WWI nursing as a contributor to the Anzac story, the authors contribute to the understanding of how marketers package and contemporize history for appeal to audiences through both sustaining and reworking cultural branding.
An empirical examination of Green Star certification uptake and its relationship with BIM adoption in New Zealand
Authors: Doan Dat Tien , GhaffarianHoseini Ali , Naismith Nicola , Ghaffarianhoseini Amirhosein , Zhang Tongrui , Tookey John 
Published: September 2021

PurposeGreen building information modelling (BIM) has been highlighted as an essential topic owing to its potential benefits. However, both Green Star and BIM are still in their earlier stages in New Zealand. This paper aims to examine and evaluate the benefits, barriers/challenges and solutions for the integration of Green Star and BIM in New Zealand.Design/methodology/approachIn this paper, a total of 77 responses collected from construction professionals in New Zealand using questionnaires were analysed through descriptive and statistical tests.FindingsBuilding performance modelling used for Green Star assessment can be implemented using BIM; this was highlighted as the most significant benefit of the integration. Whereas, the most significant barrier preventing the integration of Green Star and BIM was the fact they are two completely separate processes. Regarding the solutions for the integration, showcasing BIM-Green Star benchmark projects was considered as the most effective solution amongst a range of eight provided.Originality/valueThe research provided insights into Green Star–BIM integration in New Zealand. By evaluating the significance of the benefits, barriers/challenges and solutions for the integration, this research could be used as a guideline for Green Star and BIM development by New Zealand Green Building Council (NZGBC), the Government and construction practitioners in New Zealand. Specifically, the results here could be valuable inputs for Green Star manuals and the New Zealand BIM handbook.
Mediat(iz)ing Catholicism: saint, spectacle, and theopolitics in Lima, Peru
Authors: Norget Kristin 
Published: September 2021

AbstractThis article examines the annual public procession in Lima, Peru, of the Señor de los Milagros (Lord of Miracles) in relation to issues at the intersection of Catholic Christianity, media, and political authority. Through a theopolitical lens alert to the intermeshing of political sovereignty and authority with theological (Catholic) worldviews, I inquire into media and the Señor de los Milagros procession along three key intersecting themes that link scales of local and global Catholicism: performance, identity/belonging, and control. Key to my argument is the idea of the miraculous (lo milagroso), a culturally resonant register of embodied affective experience with compelling power, which points to how senses of belonging, authority, and ‘proper’ Catholic subjecthoods are intensified by Catholicism's diffusion through new mediatic forms, especially in church‐generated productions. A consideration of media technologies, mediation, and Catholicism nuances theoretical assumptions within the anthropology of Christianity, and also suggests that the anthropology of religion should attend more closely to mediation and mediatization as newer media infrastructures – channelling flows of information, images, and affects – extend ‘the religious’ into other social spheres.
A 10‐year retrospective review of management and outcomes of pseudoaneurysms at a tertiary referral centre
Authors: Schlegel Richard N , Clements Warren , Koukounaras Jim , Goh Gerard S , Joseph Tim , Phan Tuan , Moriarty Heather K 
Published: September 2021

AbstractIntroductionPseudoaneurysms are uncommon but potentially life‐threatening. Treatment may involve a variety of interventions including observation, manual compression, ultrasound‐guided thrombin injection and a variety of endovascular and surgical techniques. Current treatments are largely based on observational data and there is no consensus on management. This study aimed to provide evidence for guiding clinical decisions regarding visceral artery pseudoaneurysm and peripheral artery pseudoaneurysm management.MethodsRetrospective single‐centre review of patients diagnosed with visceral and peripheral artery pseudoaneurysms at a tertiary hospital (2010–2020).ResultsThere were 285 patients included in this study. A total of 86 patients were diagnosed with a visceral artery pseudoaneurysm, and 49 of these (57%) were caused by trauma. A total of 199 patients were identified with a peripheral pseudoaneurysm; 76 of these (38%) were caused by trauma and 69 (35%) were due to access site complication during an endovascular procedure. Initial technical success was achieved in 266 patients (93.3%) with 19 requiring an additional treatment to achieve success. Conservative treatment (100% success), endovascular treatment (98.1%) and surgery (100%) were more successful than ultrasound‐guided compression (63.6%) and thrombin injection (83.8%). The median time from diagnosis to intervention was <9 h for visceral artery pseudoaneurysms and 24 h for peripheral artery pseudoaneurysms. There was no change in survival outcomes with respect to time from diagnosis and intervention.ConclusionIn this study, pseudoaneurysms were treated with a high degree of success by observation or by using an endovascular approach, and those requiring endovascular intervention did not need to be treated immediately in an emergent setting.
Comprehensive analysis of treatment modes and clinical outcomes of small cell lung cancer transformed from epidermal growth factor receptor mutant lung adenocarcinoma
Authors: Wang Shouzheng , Xie Tongji , Hao Xuezhi , Wang Yan , Hu Xingsheng , Wang Lin , Li Yan , Li Junling , Xing Puyuan 
Published: September 2021

AbstractBackgroundTransformation to small cell lung cancer (SCLC) is a resistance mechanism of epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma (LADC) patients treated with EGFR tyrosine kinase inhibitors (TKIs). Here, we describe the clinical characteristics and prognosis of these patients and explore the treatment modes after transformation.MethodsEGFR‐mutant LADC patients with SCLC transformation were retrospectively included in the study. Demographic and clinical data were collected. Survival outcomes and corresponding influential factors were analyzed.ResultsTwenty‐nine patients were included in the study. The median progression‐free survival (PFS) of patients who received first‐line EGFR‐TKIs was 13.1 months. The median time to SCLC transformation was 27.5 months. After transformation, the objective response rates of patients who received first‐line chemotherapy with or without EGFR‐TKIs were 43.8% and 37.5%, respectively. The median PFS of patients reveiving chemotherapy with EGFR‐TKIs was significantly longer than that of patients receiving chemotherapy without EGFR‐TKIs (5.2 vs. 3.0 months; HR, 0.19; 95% CI: 0.05–0.72; p = 0.014). However, there was no significant difference in median overall survival (OS) between patients who received chemotherapy with or without EGFR‐TKIs (14.8 vs. 13.0 months; p = 0.474). In the multivariate Cox proportional hazards regression analysis, both anti‐angiogenic treatment (HR, 0.04; 95% CI: 0.01–0.29; p = 0.001) and local radiotherapy (HR, 0.28; 95% CI: 0.08–0.97; p = 0.044) were significantly associated with better patient OS after transformation.ConclusionsCompared with chemotherapy alone, the combination of chemotherapy and EGFR‐TKIs as first‐line treatment after SCLC transformation can benefit patients in PFS but not in OS. However, anti‐angiogenic therapies and local radiotherapy can significantly prolong OS after transformation.
At‐Most‐Hexa Meshes
Authors: Bukenberger Dennis R. , Tarini Marco , Lensch Hendrik P. A. 
Published: September 2021

AbstractVolumetric polyhedral meshes are required in many applications, especially for solving partial differential equations on finite element simulations. Still, their construction bears several additional challenges compared to boundary‐based representations. Tetrahedral meshes and (pure) hex‐meshes are two popular formats in scenarios like CAD applications, offering opposite advantages and disadvantages. Hex‐meshes are more intricate to construct due to the global structure of the meshing, but feature much better regularity, alignment, are more expressive, and offer the same simulation accuracy with fewer elements. Hex‐dominant meshes, where most but not all cell elements have a hexahedral structure, constitute an attractive compromise, potentially unlocking benefits from both structures, but their generality makes their employment in downstream applications difficult. In this work, we introduce a strict subset of general hex‐dominant meshes, which we term ‘at‐most‐hexa meshes’, in which most cells are still hexahedral, but no cell has more than six boundary faces, and no face has more than four sides. We exemplify the ease of construction of at‐most‐hexa meshes by proposing a frugal and straightforward method to generate high‐quality meshes of this kind, starting directly from hulls or point clouds, for example, from a 3D scan. In contrast to existing methods for (pure) hexahedral meshing, ours does not require an intermediate parameterization of other costly pre‐computations and can start directly from surfaces or samples. We leverage a Lloyd relaxation process to exploit the synergistic effects of aligning an orientation field in a modified 3D Voronoi diagram using the norm for cubical cells. The extracted geometry incorporates regularity as well as feature alignment, following sharp edges and curved boundary surfaces. We introduce specialized operations on the three‐dimensional graph structure to enforce consistency during the relaxation. The resulting algorithm allows for an efficient evaluation with parallel algorithms on GPU hardware and completes even large reconstructions within minutes.
Development of mesoporous bioactive glass‐containing macroporous titanium for controlled release of antimicrobial drugs
Authors: Kamarudin Nur Hidayatul Nazirah , D'Haeyer Camille , Thevissen Karin , Braem Annabel 
Published: September 2021

AbstractBiofilm‐associated infections pose a serious threat to the long‐term survival of metal‐based bone implants, which can potentially be resolved by the controlled delivery of antimicrobial agents locally at the implant surface. Mesoporous bioactive glasses (BAGs) are multifunctional materials able to combine bone‐bonding properties with such a drug release functionality. Here, we propose for the first time to modify a macroporous Ti implant material with an antimicrobial‐releasing BAG phase. The feasibility of a sol‐gel synthesis route, including the structure‐directing agent (SDA) Pluronic F127, and its effect on the mesoporous structure and concomitant drug release performance was evaluated. Mesopore sizes ranged from 3.4 nm for SDA‐free to 3.7 nm for SDA‐derived BAG, thereby both enabling configurational diffusion of the antiseptic chlorhexidine (CHX), but the latter showed a more narrow pore size distribution leading to a slower, more controlled release. Adjusting the feed concentration allowed fine‐tuning the daily CHX release through the SDA‐derived Ti/BAG composite to 1.4 μM. Even though just below the biofilm inhibitory concentration, this daily release rate was sufficient to effectively prevent Streptococcus mutans biofilm formation on the surface of the material. This proof‐of‐concept for a temporary antimicrobial‐releasing bioceramic surface modification on Ti can be of interest for orthopedic implants.
Reproductive trade‐offs and phenotypic selection change with body condition, but not with predation regime, across island lizard populations
Authors: Cox Robert M. , Wittman Tyler N. , Calsbeek Ryan 
Published: September 2021

AbstractTrade‐offs between reproduction and survival are central to life‐history theory and are expected to shape patterns of phenotypic selection, but the ecological factors structuring these trade‐offs and resultant patterns of selection are generally unknown. We manipulated reproductive investment and predation regime in island populations of brown anole lizards (Anolis sagrei) to test (1) whether previously documented increases in the survival of experimentally non‐reproductive females (OVX = ovariectomy) reflect the greater susceptibility of reproductive females (SHAM = control) to predation and (2) whether phenotypic selection differs as a function of reproductive investment and predation regime. OVX females exceeded SHAM controls in growth, mass gain and body condition, indicating pronounced energetic costs of reproduction. Although mortality was greatest in the presence of bird and snake predators, differences in survival between OVX and SHAM were unrelated to predation regime, as were patterns of natural selection on body size. Instead, we found that body condition at the conclusion of the experiment differed significantly across populations, suggesting that local environments varied in their ability to support mass gain and positive energy balance. As mean body condition improved across populations, the magnitude of the survival cost of reproduction increased, linear selection on body size shifted from positive to negative, and quadratic selection shifted from stabilizing to weakly disruptive. Our results suggest that reproductive trade‐offs and patterns of phenotypic selection in female brown anoles are more sensitive to inferred variation in environmental quality than to experimentally induced variation in predation.