bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Data Analysis and Structural Reliability of Foundation Pit During Construction: A Case Study
Authors: Meng Guowang , Qiu Hongbin , ZHao Yajie , Wu Bo , Gao Da , Huang Wei , Liu Guixiang 
Published: September 2021

Abstract
In order to solve the problem that only considering the deformation of the side wall or the ground settlement of a single factor of the reliability evaluation may lead to insecurity, a deformation reliability evaluation method considering both the deformation of the side wall and the ground settlement is proposed. This evaluation method is used to evaluate the reliability of foundation pit structure deformation of Jinan metro in Shandong Province, China. Through the study of the deformation of the side wall and ground settlement loss on six profiles, the influence of the coefficient (λ、α and β) on the reliability is considered, and the recommended value of the coefficient (λ、α and β) is given. The reliability of six profiles is evaluated and the reliability level is obtained successfully. The reliability evaluation method can solve the problem that considering a single failure mode may lead to insecurity, and can provide an effective solution to the reliability evaluation of foundation pit retaining structure deformation.
Ellagic Acid Cytotoxic and Metalloproteinases Inhibitory Effects Against Oral Squamous Cell Carcinoma: An in Vitro Study
Authors: Zago Patricia Maria Wiziack , Hellmeister Luiza Rodrigues , Teixeira Lucas Novaes , Junior Rui Barbosa de Brito , Martinez Elizabeth Ferreira 
Published: September 2021

Abstract
ObjectivesThis study aimed to evaluate the in vitro antitumoral potential of different concentrations of EA against two OSCC cell lines with distinct tissue invasiveness profiles. Material and methodsNormal keratinocytes (NOK) and OSCC´s cells CAL-27 and SCC-9 were treated with concentrations of EA varying from 5 to 662 µM during 24, 48 or 72h. After each time of treatment, cells were submitted to viability analysis using MTT and the secretion of metalloproteinases (MMP-2 and MMP-9) and tissue metalloproteinases inhibitors (TIMP-1 and TIMP-2) were performed by Enzyme-Linked Immunoassay (ELISA). Data were submitted to ANOVA, followed by Bonferroni´s test, considering 5% as significance level. ResultsEA was cytotoxic to OSCC cells in all exposure times, rarely affecting normal cell viability, except for concentrations higher than 82 µM and after 72h treatment. For OSCC cells, EA decreased MMPs and increased TIMPs´s expression without effect on those enzymes for normal cell lines during all times of exposure. ConclusionEA is a promising therapeutic adjuvant to treat oral cancer, however, further in vivo studies are required to clinically validate its potential. Clinical RelevanceThe in vitro anticancer properties showed by Ellagic acid, a phenolic compound that could easily be accessed by oral cancer patients, provides data to base future clinical studies intended to develop a safe topical oral anticancer product.
Rutin Reverses Abnormal Autophagy in Hypoxic Pulmonary Arterial Hypertension via Regulation of Mitofusin 1
Authors: Huang Ming-xue , Wang Man , Song Yu-wei , Song Yan , Jing Ling 
Published: September 2021

Abstract
Background:Recently, rutin, a citrus flavonoid occurring in many plants, has been found to be beneficial in preventing hypoxia-induced pulmonary arterial smooth muscle cells (PASMCs) from proliferating via scavenged reactive oxygen species (ROS). However, rutin’s underlying mechanism of action against PASMCs in the context of hypoxia is still unclear. Autophagy, the main intracellular degradation and recycling process, exerts a critical adaptive effect on the pathological angiogenesis associated with hypoxic pulmonary arterial hypertension (HPAH) by removing damaged mitochondria and regulating ROS production and cell proliferation. It would be useful to identify the role of rutin and its interaction with autophagy in exerting protective effects against HPAH.Methods:We chose 21 SD rats and randomly and equally divided them into three groups of normoxia, hypoxia, and hypoxia + rutin. At the end of the exposure period, we measured the right ventricular systolic pressure (RVSP), the weight of right ventricle (RV), and the ratio of RV weight to left ventricular (LV) weight plus septum (RV/LV+S) of each rat. PASMCs of the three groups of rats were isolated and cultured, and the effect of rutin on autophagy-related protein expression under hypoxia was analyzed using immunofluorescence analysis, transmission electron microscopy, western blot (WB) analysis, and siRNA design and transfection.Results:We found RVSP, RV/LV+S, and pulmonary artery wall thickness were reduced by rutin in the pulmonary arterial hypertension (PAH) animal model. WB results showed that rutin regulated expression of autophagy-related proteins. Moreover, rutin downregulated Mitofusin 1 (Mfn1) over-expression induced by hypoxia. But when Mfn1 was silenced, there was little difference in the expressions of beclin-1 (BECN-1), and other marker proteins with or without rutin.Conclusions:Rutin suppressed the abnormal autophagy of hypoxia-induced PASMCs via the regulation of the target, Mfn1. This revealed the protective effect of rutin on vascular remodeling caused by hypoxia and demonstrated how rutin could slow down the development of HPAH.
Crack Detection in Folded Plates With Back-Propagated Artificial Neural Network
Authors: Gonenli Can , Das Oguzhan , Das Duygu Bagci 
Published: September 2021

Abstract
Engineering structures may face various damages such as crack, delamination, and fatigue in several circumstances. Localizing such damages becomes essential to understand the health of the structures since they may not be able to operate anymore. Among the damage detection techniques, non-destructive methods are considerably more preferred than destructive methods since damage can be located without affecting the structural integrity. However, these methods have several drawbacks in terms of detecting abilities, time consumption, cost, and hardware or software requirements. Employing artificial intelligence techniques could overcome such issues and could provide a powerful damage detection model if the technique is utilized correctly. In this study, the crack localization in flat and folded plate structures has been conducted by employing a Back-propagated Artificial Neural Network (BPANN). For this purpose, cracks with 18 different dimensions have been modeled in flat and four different folded structures by utilizing the Finite Element Method. The dataset required to perform the crack localization procedure includes the first ten natural frequencies of all structures as input variables. As output variables, the dataset contains a total of 500 crack locations for five structures. It is concluded that the BPANN can localize all cracks with an average accuracy of 95.12%.
A Clinical Predictive Model of Progesterone Elevation on the Day of HCG Administration Was Establish Based on the Basal P, BMI and Ovarian Induction Regimen
Authors: yu chunmei , zhou chao , dai xiuliang , zhou jianmei , yang haiyan , wang yufeng , Chen li 
Published: September 2021

Abstract
Background The progesterone elevation (PE) on the day of human chorionic gonadotrophin (hCG) is associated with a significant decrease in the probability of clinical pregnancy after fresh embryo transfer. The goal of this study was to develop a nomogram to explore the baseline indexes to predict the occurrence of PE (0.9ng/ml) on the day of HCG administration before IVF/ICSI treatment.Methods The patients who were performed a GnRH agonist or antagonist pituitary suppression protocol during controlled ovulation stimulation(COS) in reproductive center of Changzhou maternal and child health care hospital from 2017-2019 were included. The nomogram was built from all participants.Results Three variates significantly associated with the PE occurrence on the HCG administration of infertility women were the type ovulation regiment, basal P and BMI. This predictive model showed good calibration and discriminatory abilities, with an area under the curve (AUC) of 0.639（95%CI 0.596~0.681）. Hosmer and Leme show test were performed for evaluating both calibration and discrimination and confirmed our nomogram is a user-friendly graphical representation of the model (χ2= 4.750，P=0.784)Conclusion The nomogram presents graphically association factors (type ovulation regiment, basal P and BMI) and prediction models which can offer simple and useful guidance to avoid the PE occurrence on the HCG administration for clinicians and infertility patients.
The Colonization of Vancomycin-Resistant Enterococcus (VRE): Prevalence, Molecular Epidemiology, and Risk Factors in Patients Admitted to Intensive Care Units in Beijing.
Authors: Yan Mengyao , He Yuanhui , Ruan Genjie , Xue Feng , Zheng Bo , Lv Yuan 
Published: September 2021

Abstract
Background: Vancomycin-resistant Enterococcus (VRE), as an important nosocomial pathogens, can be carried in gut for a long period and its colonization status associated with the subsequent infections. The aim of this study was to investigate the frequency of intestinal VRE colonization and identify the risk factors associated with VRE carriage in intensive care patients.Methods: We conducted a 4-week cross-sectional study at six hospitals in Beijing, China. Patients admitted to Intensive Care Units (ICUs) were screened for intestinal colonization of VRE every Tuesday morning. Rectal swabs were selectively cultured for VRE, then the identified strains were analyzed by PCR to detect the glycopeptide resistance gene and were characterized by MLST. Risk factors were recorded to assess their effect on VRE acquisition during ICUs stay.Results: Of 148 patients recruited, 46 (31.1%) were colonized with VRE, with the majority (n=42) being Enterococcus faecium. In total, 78.3% of the VRE were vanA positive and 15.2% vanM positive, while 6.5% undetected glycopeptide resistance gene. The predominant ST was ST78 (47.6%) followed by ST192 (14.3%), ST555 (9.5%), ST789 (9.5%), ST547 (4.8%), and ST922 (4.8%). Risk factors associated with VRE carriage were age of >65 years, a longer length of ICU stay, use of an endotracheal tube, and prior glycopeptides use.Conclusions: The overall incidence proportion of VRE colonization at ICUs was relatively high in Beijing, and clonal expansion and horizontal transmission of resistant genes were both found here. Routine screening is necessary to prevent the dissemination of VRE.
Long-term Metal Fume Exposure Assessment of Workers in a Shipbuilding Factory
Authors: Wang Ying-Fang , Kuo Yu-Chieh , Wang Lin-Chi 
Published: September 2021

Abstract
This study aims to assess the metal fume exposure of welders and to determine exposure rates for similar exposure groups in a shipyard through the use of Near-field/Far-field (NF/FF) mathematical models and Bayesian decision analysis (BDA) technique. Emission rates of various metal fumes (i.e., total chromium (Cr), iron (Fe), lead (Pb), manganese (Mn), and nickel (Ni)) were experimentally determined for the gas metal arc welding and flux cored arc welding processes, which are commonly used in shipyards. Then the NF/FF field model which used the emission rates were further validated by welding simulation experiment, and together with long-term operation condition data obtained from the investigated shipyard, the predicted long-term exposure concentrations of workers was established and used as the prior distribution in the BDA. Along with the field monitoring metal fume concentrations which served as the likelihood distribution, the posterior decision distributions in the BDA were determined and used to assess workers’ long-term metal exposures. Results show that welders’ Fe, Mn and Pb exposures were found to exceed their corresponding action levels with a high probability, indicating preventive measures should be taken immediately. The proposed approach provides a universal solution for conducting exposure assessment with usual limited number of personal exposure data.
Effect of Cleft Lip With or Without Palate on Pediatric General and Dental Growth in Korea: a Nationwide Population-based Cohort Study
Authors: Ryu Jeong Yeop , Park Tae Hyun , Lee Joon Seok , Yang Jung Dug , Chung Ho Yun , Cho Byung Chae , Choi Kang Young 
Published: September 2021

Abstract
There are very few nationwide studies discussing the height, weight, head circumference, and dental screening of children with cleft lip with or without palate (CL/P), with most reports on this subject based on a 1900s cohort. This study aimed to characterize CL/P children in the 2000s in terms of height, weight, head circumference, and dental screening. This nationwide population-based study evaluated the National Health Insurance Service-Infants and Children’s Health Screening (NHIS-INCHS), specifically the height, weight, and head circumference of millions of children. Dental screening data, including the status of each tooth and comprehensive dental judgment, were also evaluated. Syndromic and nonsyndromic CL/P children had lower height, weight, and head circumference than no CL/P children until the age of 66–71 months. Children with cleft palate only or both cleft lip and palate showed similar results. Regarding dental screening, the primary teeth of CL/P children erupted later and fell out faster than no CL/P children. Dental caries was also more common in CL/P children. Children with CL/P had inferior general growth, regardless of palatoplasty surgery. More aggressive dental treatment was required for CL/P children due to the instability of primary teeth and tendency for caries.
Simulation of the Thermal Aberration of Fused Silica Reflective Optics Under High-power Laser Irradiation
Authors: Li Yuan , Yu HongMing , Yin XinQi , Wu Juan , Wang Feng , Zou Kai , Yan Hong , Li JianMin , Luo Jia 
Published: September 2021

Abstract
The output beam quality of high-power laser systems is limited by laser-induced thermal aberration of fused silica reflective optics. A numerical model for the simulation of thermal aberration was proposed and verified by the experimental results. Simulations on the thermal aberration of fused silica optics under 3~10 kW laser irradiation with laser beam diameters of 5 mm ~ 45 mm were carried out with the verified model. The simulation results showed that the peak-valley (PV) value of thermal aberration increases with increasing incident laser power under the same incident laser spot size and reduces with increasing incident laser spot size under the same incident laser power. There are the same PV values of thermal aberration under different incident power or power densities. An analytic formula of thermal aberration PV as a function of incident laser power and beam spot size was proposed. The analytic results are in good agreement with the simulations. With these conclusions, the thermal aberration of fused silica optics under high incident power and power density can be evaluated by that under low incident power and power density. It is helpful for the design of high-power laser systems to obtain reasonable output beam quality.
Performance comparison and in-silico harmonization of commercial platforms for DNA methylome analysis by targeted bisulfite sequencing
Authors: Tanic Miljana , Moghul Ismail , Rodney Simon , Dhami Pawan , Vaikkinen Heli , Ambrose John , Barrett James , Feber Andrew , Beck Stephan 
Published: September 2021

Abstract
DNA methylation is a key epigenetic modification in the regulation of cell fate and differentiation, and its analysis is gaining increasing importance in both basic and clinical research. Targeted Bisulfite Sequencing (TBS) has become the method of choice for the cost-effective, targeted analysis of the human methylome at base-pair resolution. Here we benchmarked five commercially available TBS platforms, including three hybridization capture-based (Agilent, Roche, and Illumina) and two RRBS-based (Diagenode and NuGen), across 11 samples. A subset of these were also compared to whole-genome DNA methylation sequencing with the Illumina and Oxford Nanopore platforms. We assessed performance with respect to workflow complexity, on/off-target performance, coverage, accuracy, and reproducibility. We find all platforms able to produce usable data but with major differences for some performance criteria, especially in the number and identity of the CpG sites covered, which affects the interoperability of datasets generated on these different platforms. To overcome this limitation, we used imputation and show that it improves the interoperability from an average of 10.35% (0.8M CpG sites) to 97% (7.6M CpG sites). Our study provides cross-validated guidance on which TBS platform to use for different features of the methylome and offers an imputation-based harmonization solution for improved interoperability between platforms, allowing comparative and integrative analysis.
An analysis of the risk factors for falls, recurrent falls, and fall-related injuries among the elderly in senior Chinese apartments: a cross-sectional study
Authors: Su Qingqing , Song Mi , Zhang Jie , Mao Yazhan , Song Jie , Pi Hongying 
Published: September 2021

Abstract
Objective
Falls, recurrent falls, and fall-related injuries among the elderly are severe problems that seriously threaten the quality of life and health in old age. However, there are few studies on fall risks among the elderly living in senior apartments in China. Our study aims to investigate the factors and differences in falls, recurrent falls, and fall-related injuries among these elderly residents, providing a reference for screening those with high fall risks.
Method
Face-to-face structured interviews were conducted on 331 older adults over 65 years of age living in four senior apartments. We performed comparative analyses on the results of fall events with two separate criteria (falls vs. no falls; number of falls ≤ 1 and without injury vs. fall-related injuries or number of falls ≥ 2). Several significant variables were involved in a logistic model for regression analysis.
Results
Falls, recurrent falls, and fall-related injuries among the elderly in senior apartments were independently associated with gender (female), urinary incontinence/frequency, and conscious unsteady gait. Furthermore, fall risks increased with age and the number of risk factors. The AUC, sensitivity, and specificity of the fall risk prediction model were 0.749, 82.4%, and 57.1%, respectively.
Conclusions
Falls among the elderly in senior apartments are affected by several factors. Female elderly with urinary incontinence/frequency and conscious unsteady gait should be prioritized for fall prevention interventions.
Drug Resistance in NSCLC is Associated with Tumor Micro-environment
Authors: Ke Yizhong , Huang Pinzheng , Li Lixi , Jin Mingming , Huang Gang 
Published: September 2021

Abstract
IntroductionTumor cell resistance to chemotherapy is the most critical factor that influences the prognosis of cancer patients. It is generally believed that drug resistance is caused by genetic alterations in tumor cells; however, the relationship between drug resistance and the tumor microenvironment (TME) has not been adequately studied.MethodsHerein, we successfully identified drug resistance and sensitivity clusters using single-cell transcriptome sequencing data from GSE149383 and established a proportional hazards model to find genes that affected prognosis.ResultsThe results showed that marker genes between resistant and sensitive clusters were significantly associated with the TME; additionally, the model showed good reliability. Furthermore, we used bulk RNA-seq data to analyze the expression of CD24 and CYP1B1, which revealed little difference in the levels of the two genes in normal and tumor tissues but a significant difference in their expression between drug-resistant and -sensitive cells.ConclusionIn conclusion, our study demonstrated a link between drug resistance and the TME, and we found that CD24 and CYP1B1 may be key regulators of drug resistance development in tumor cells via altering the TME.
Fretting Wear Mechanical Analysis of Double Rough Surfaces Based on Energy Method
Authors: Li Ling , Li Ganghua , Wang JingJjing , Shi Xiaohui , Cai Anjiang 
Published: September 2021

Abstract
A fretting wear model of rough surface that conforms to the actual situation is established to accurately reveal the wear mechanism of the connection structure. In the ABAQUS software, the UMESHMOTION subroutine and the energy dissipation model are used to simulate the fretting wear of double rough surfaces. The new model, a single rough surface model, and a smooth model are compared to analyze the differences between them. In addition, the influence of surface roughness, material, and friction coefficient on the fretting wear of rough surfaces is systematically explored through finite element simulation. The results show that the reliability of the model has been verified through Hertz’s theory and experiments. The stress and wear of the contact surface are more realistically reflected by the double roughness model. Besides, with the increase of surface roughness and material rigidity and the decrease of friction coefficient, the wear of the double rough surface model becomes more severe. The research work provides a theoretical basis for the design and performance prediction of the connection structure.
How deep is your thought? The relations between intolerance of uncertainty, worry and weight and shape concerns in adolescent girls with anorexia nervosa
Authors: Bijsterbosch Jojanneke , Keizer Anouk , Boelen Paul , Danner Unna , Sternheim Lot 
Published: September 2021

Abstract
Background
Inherent to anorexia nervosa (AN) are repetitive thoughts about weight and shape. Growing research suggests the relevance of intolerance of uncertainty (IU) and worry in maintaining these types of repetitive thoughts. The relation between these cognitive processes and weight and shape concerns in adolescents with AN is understudied. This study aims to investigate associations between prospective and inhibitory IU, worry, and weight and shape concerns.
Methods
In a cross-sectional study, 93 adolescent girls with AN completed three questionnaires, measuring prospective and inhibitory IU, worry, and weight and shape concerns, respectively. A mediation model with worry as a mediator between inhibitory IU and prospective IU and weight and shape concerns was tested.
Results
A direct and total effect of inhibitory IU on weight and shape concerns was found. Worry did not mediate the relation between inhibitory or prospective IU and weight and shape concerns.
Conclusions
These results confirm the importance of inhibitory IU in adolescents with AN, more specifically to weight and shape concerns. This group may benefit from intervention strategies targeting IU. Worry seems less relevant to weight and shape concerns in adolescents.