bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Factors of the Sustainable Supply Chain in the Post-COVID-19 Pandemic: SWARA Approach
Authors: HAYAT KHIZAR , JIANJUN ZHU , Ali Sharafat , Khan Muhammad Adeel 
Published: June 2021

Abstract
The present research aimed to provide a mechanism for enhancing sustainable supply chain survivability during and after the COVID-19 outbreak. The working system for firms and employees has been restricted worldwide due to the COVID-19 pandemic, including working on-sites, different areas, and working hours. Therefore, the system changed into a network economy to reduce unemployment and increase the work opportunities for workers. As a result, businesses are now attempting to improve the system for sustainable supply chains. The Stepwise Weight Assessment Ratio Analysis (SWARA) approach is used in this research to classify dynamic aspects for improving the survival of sustainable supply chains in an epidemic condition. The results reveal that the viability of the supply chain network is the essential criteria for managing the relationships of suppliers and buyers and maximizing sustainable supply chain survivability during and after COVID-19. This research will help businesses, manufacturers, and other stakeholders to concentrate on the described factors to achieve a brighter environment.
Traditional Husbandry Practices of Goats in Selected Districts of Sidama Zone, Southern Ethiopia
Authors: Woldeyohannes Tariku , Hankamo Amsale , Banerjee Sandip 
Published: June 2021

Abstract
The aim of this study was to describe goat production system in two districts of Sidama zone of southern Ethiopia using two production systems. Semi-structured questionnaire was developed and employed to gather information regarding the management activities, purpose of keeping goats and selection criteria of farmers to select breeding animals. A total of 240 households were interviewed to collect relevant information for the study. Data collected from questionnaire was statistically analyzed and summarized into descriptive statistics. Indexes was calculated to clarify rankings by using indexes formula. The number goat population is more in Loka Abaya than Aroresa. The primary purpose of keeping goats study area are mainly for their milk, meat and income generation. The reproductive potential of Does reared in the Aroresa district was lower. Broad shoulders, compact frame and short and thick necks of the Bucks were considered as the most important characteristics for selection. Communal grazing and crop aftermath were the most common feed sources reported by farmers in the study area. River was the major water source for goats in the study districts. The major factors limiting the productivity of goats are feed shortage, diseases, labour shortage and lack of improved goat breeds.
Investigating the Natural History and Prognostic Nature of NTRK Gene Fusions in Solid Tumors
Authors: Zhu Limin , Hobbs Brian , Roszik Jason , Holla Vijaykumar , Hong David S. 
Published: June 2021

Abstract
BackgroundSeveral TRK inhibitors have demonstrated clinical efficacy in patients with solid tumors harboring NTRK gene fusions. However, the natural history and prognostic implications of NTRK fusions in solid tumors remain unknown.MethodsA cohort of 77 MD Anderson Cancer Center patients (MDACC) with NTRK gene fusions was identified and retrospectively compared to a second cohort from the Cancer Genome Atlas (TCGA) database. Due to paucity of events in early stage cancers and lack of TCGA data in rare tumors, 25 randomly selected MDACC patients were matched to 122 TCGA patients without NTRK gene fusion. Next we assessed the associations between NTRK gene fusion and overall (OS) and progression-free survivals (PFS).ResultsAmong the 77 MDACC patients with NTRK gene fusions, 18 NTRK fusion partners were identified. There were insufficient OS events for analysis in the matched cohort. PFS was not significantly different (p=0.49) between the NTRK-fusion positive MDACC patients (median PFS 786 weeks, 95% CI 317-NE) and the NTRK-fusion negative TCGA patients (median PFS NE). The adjusted hazard ratio comparing TCGA patients to MDACC patients was HR=0.72 (95% CI: 0.23-2.33), which trended towards a reduced rate of progression or death experienced by TCGA patients.ConclusionsThis study did not identify statistically significant associations between NTRK fusion and PFS. Nonsignificant trends estimated increases in the risk of progression or death events for patients with NTRK fusions when compared to matched controls. Our findings help illuminate the influence of NTRK fusions on the natural history of a variety of solid tumors.
Resource Allocation Strategy for D2D-Assisted Edge Computing System Using Weighted Genetic and Ant Colony Optimization Algorithms
Authors: Teja Devireddy Pranav Krishna , Nikhileswar Kuppachi , Abhiram Adusumili Lalith Peri Abhiram Peri , S Nandakumar 
Published: June 2021

Abstract
Due to the constrained battery ability and computing functionality of cellularcustomers, the Resource allocation approach in D2D-assisted edge computingsystem with hybrid electricityharvesting is investigated on thisdocument.By using magnetic induction-primarily based on wireless reverse charging technology, cellular consumer can complement more electricity from nearby users whilst the electricity gathered from the surrounding radio frequency is set to be exhausted. Due to the constrained computing resource of MEC server the MEC server reaches the limit of its computing capability the adjacent Base station’s user can act as a relay node and by setting up the D2D relay links the computing responsibilities of the users which are left under previous base station can now be transferred to new base station’s MEC server which has enough resources. The goal of the resource allocation approach is to improvise the energy efficiency under computation delayconstraint and energy harvestingconstraints.An optimal answer is produced by adopting the Quantum behaved Particle Swarm Optimization (QPSO) algorithm, weighted genetic algorithm (WGA/GA) and Ant-colony optimization (ACO) algorithm, Simulation outcomes display that overall performance of theapproach that is proposed is superior than different benchmark strategies, and weighted genetic algorithm (WGA), Ant-colony optimization (ACO) algorithmcan attain better energy efficiency than the quantum behaved particle swarm optimization and standard particle swarm optimization algorithm also Simulation studiesshows that the self-learning nature of these methods(i.e WGA and ACO) gives better results even for higher complexity problems.
Beneficial Effect of Dimethyl Fumarate on Experimental Autoimmune Uveitis is Dependent of Pro-Inflammatory Markers Immunomodulation
Authors: TOUIL-BOUKOFFA Chafia , Labsi Moussa , Soufli Imene , Belguendouz Houda , Djebbara Sara , Hannachi Leila , Amir Zine-Charaf 
Published: June 2021

Abstract
Autoimmune uveitis is an inflammatory disease of the eye and is one of the major causes of blindness worldwide. Experimental autoimmune uveoretinitis (EAU) constitutes an animal disease model of human endogenous uveitis. In our study, we investigated the immunomodulatory effect of Dimethylfumarate (DMF) using bovine retinal extract-induced uveitis in a Female Wistar rats. To evaluate the in vivo efficacy, Female Wistar rats were divided into 7 experimental groups: control group (n = 5), consisting of non-immunized animals; Uveoretinitis (n = 5), and DMF/Uveoretinitis groups (n = 15), which received a subcutaneous injection of bovine retinal extract emulsified in complete Freund’s adjuvant; MC group (n = 5), treated by daily intragastric administration of methylcellulose 0.08% in tap water; DMF group, consisting of control positive group, rats received daily oral gavage administration of 500 µL of Dimethylfumarate at 100mg/Kg dissolved in 0.08% methylcellulose in tap water (n = 5). On days 14 post immunization, the rats were then euthanized and associated indications were investigated to evaluate the therapeutic efficacy. Nitric oxide (NO) and TNF-α were assessed in plasma. Meanwhile, eyes were collected for histological and immunohistochemical studies. The retinal expression of iNOS, CD68, CD20, CD25, CD4, and CD8 was examined. Interestingly, DMF enhanced a significant reduction of NO and TNF-α production in the treated group. This effect was strongly related to the histological structure of eyes improvement. In the same context, a significant decrease of iNOS, CD68, and CD20 expression and CD25 increase expression were reported in retinal tissue of DMF/Uveoretinitis group in comparison to the immunized group. Collectively, our results indicate that DMF treatment has a beneficial effect in experimental autoimmune uveoretinitis and could constitute a good candidate for monitoring an ocular inflammatory diseases.
The Associations of Urinary DEHP Metabolites Levels, Serum Thyroid Hormones and Thyroid Related Genes Among the Adolescent Students from China – A Cross-Sectional Study
Authors: Zhao Yaming , Song Xinyue , Ding Shuang , Qi Wen , Zhang Yuezhu , Xu Qi , Zhao Tianyang , Zhang Xueting , Li Xu , Wu Fuju , Ye Lin 
Published: June 2021

Abstract
Our study aimed to investigate the associations between DEHP exposure and serum thyroid hormone levels in 347 adolescents and young adults. We measured DEHP metabolites including mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) and mono(2-carboxmethyl)hexyl phthalate (MCMHP) in their urine. Total thyroxine (TT4), total triiodothyronine, free triiodothyronine, free thyroxine (FT4), thyroid-stimulating hormone and the mRNA levels of thyroid peroxidase (TPO), thyroglobulin (TG), sodium iodide symporter (NIS), thyroid transcription factor 1 (TTF-1) and paired box gene 8 (PAX-8) in serum were measured. The results of statistical analysis showed that urinary DEHP metabolites were generally negatively associated with TT4 levels in serum. In the males, the FT4 levels showed positive associations with urinary MEHP, MECPP, MCMHP, and ∑DEHP. The mRNA level of TG was significantly positively correlated with the levels of MECPP, MCMHP and ∑DEHP, while the level of NIS mRNA was significantly positively correlated with the levels of MEOHP. There was a significant positive correlation between TTF-1 mRNA level and urinary MEOHP, MECPP, MCMHP and ∑DEHP.
Mesquite Pod (Prosopis Juliflora) meal on Meat Quality of Pasture-Finishing Lambs
Authors: Junior Mário Sergio Fernandes Soares , de Souza Kennyson Alves , Almeida Bruna de Jesus , de Araújo Fabiana Lana , Silva Cristiane Simplício da , de Oliveira Ana Patricia David , Cardoso Claudia Andrea Lima , de Goes Rafael Henrique De Tonissi e Buschinelli , Bagaldo Adriana Regina 
Published: June 2021

Abstract
This study was carried out to evaluate the best inclusion level and the effects of mesquite pod (Prosopis juliflora) meal on carcass characteristics and meat quality for lambs finished in pasture. Forty male, non-castrated, crossbred Santa Inês lambs, with an initial body weight (24.2 ± 3.1 kg), and approximately 120-days old. The animals were kept in a total area of ​​4 ha, divided in 4 paddocks of 0.62 ha each (10 animals/paddocks), on pastures of Massai (Panicum maximum cv. massai) with drinkers and feeders during the finishing phase. Dietary treatments based on levels of corn ground replacement for mesquite pod meal included: CON – Without mesquite pod meal; MPM25 – 250 g/kg of mesquite pod meal; MPM50 – 500 g/kg of mesquite pod meal; and MPM75 – 750 g/kg of mesquite pod meal. No treatment effects were detected (P> 0.05) for carcass measures, carcass characteristics, chemical composition of longissimus thoracis muscle, tissue composition, and lipid oxidation. Lamb meat color values, such as lightness (L*) and yellowness (b*) were not affected (P> 0.05) by mesquite pod meal replacement on the diets, whereas for redness (a*), HUE, and crhoma were influenced (P< 0.05). Palmitic acid had a quadratic effect, while oleic acid, eicosatrienoic acid, saturated fatty acids, monounsaturated fatty acids, and PUFA:SFA had a linear course (P< 0.05). In conclusion the mesquite pod meal can be used as an energy feed source up to 750 g/kg of dry matter in the diet, without changing the carcass characteristics and meat quality of lambs finished in pasture.
The Influence of Saturated Steam on Moso Bamboo Quasi-static Micromechanical Properties: Nano-Scale Evaluation
Authors: Yuan Tiancheng , Wang Zhaoshun , Han Xin , Yuan ZhuRun , Wang XinZhou , Li yanjun 
Published: June 2021

Abstract
In this paper, in order to analyze the quasi-static properties of Moso bamboo, a new, environmentally friendly and eco-friendly method was used for bamboo thermal modification under the effect of saturated steam. Under saturated steam heat treatment, the chemical composition in bamboo decreased, and the bamboo cell wall shrunk slightly. The increased crystallinity index of cellulose and decreased intensity of peaks belong to hemicellulose were confirmed by XRD and Fourier transform infrared (FTIR) spectroscopy. In addition, the highest modulus of elastic and hardness of treated bamboo were 22.5GPa and 1.1GPa at 180℃/10 min. These conclusions confirmed the micro-mechanical properties of the bamboo cell wall were enhanced by saturated steam heat treatment. The E'r of differently treated bamboo increased with increasing temperature and time, while the E''r and tan δ negatively as a function of increasing frequency. Furthermore, this thermal modification can be regarded as a useful, environmental-friendly and eco-friendly treatment to outdoor use of bamboo-based materials.
Genome-wide Analysis of Circular RNAs and Validation of hsa_circ_0086354 As a Promising Biomarker for Early Diagnosis of Cerebral Palsy
Authors: Hu Yuanyuan , Bian Xuzhao , Wu Chao , Wang Yan , Wu Yang , Sun Shiquan 
Published: June 2021

Abstract
Background: Cerebral palsy (CP) is a spectrum of non-progressive motor disorders caused by brain injury during fetal or postnatal periods. Current diagnosis of CP mainly relies on neuroimaging and motor assessment. Here, we aimed to explore novel biomarkers for early diagnosis of CP. Methods: Blood plasma from five CP children and their healthy twin brothers/sisters was analyzed by gene microarray to screen out differentially expressed RNAs. Selected differentially expressed circular RNAs (circRNAs) were further validated using quantitative real-time PCR. Receiver operating characteristic (ROC) curve analysis was used to evaluate the value of using hsa_circ_0086354 as a biomarker of CP.Results: 43 up-regulated circRNAs and 2 down-regulated circRNAs were obtained by difference analysis (fold change>2, p<0.05), among which five circRNAs related to neuron differentiation and neurogenesis were chosen for further validation. Additional 30 pairs of CP children and healthy controls were recruited and five selected circRNAs were further detected, showing that hsa_circ_0086354 was significantly down-regulated in CP plasma compared with control, which was highly in accord with microarray analysis. ROC curve analysis showed that the area under curve (AUC) to discriminate CP children and healthy controls using hsa_circ_0086354 was 0.967, the sensitivity was 0.833 and the specificity was 0.966. Moreover, hsa_circ_0086354 was predicted as a competitive endogenous RNA for miR-181a, miR-4741 and miR-4656, and much literature evidence suggested that miR-181a may be a key target of hsa_circ_0086354 to regulate neuronal survival and neuronal differentiation. Conclusion: Hsa_circ_0086354 was significantly down-regulated in blood plasma of CP children, which may be a novel competent biomarker for early diagnosis of CP.
Transferring Cognitive Talent Across Domains: The Case of Finance
Authors: Rotaru Kristian , Kalev Petko S. , Yadav Nitin , Bossaerts Peter 
Published: June 2021

Abstract
We consider Theory of Mind, the ability to correctly predict the intentions of others. The skill requires abstraction from one’s own particular circumstances. Here, we posit that such abstraction can be transferred successfully to other, non-social contexts. We consider the disposition effect, which is a pervasive cognitive bias whereby investors, including professionals, improperly take their personal trading history into account when deciding on investments. We design an intervention policy whereby we attempt to transfer Theory of Mind skills, subconsciously, to personal investment decisions. In a within-subject repeated-intervention laboratory experiment, we record how the disposition effect is reduced by a very significant 85%, but only for those with high Theory of Mind skills. No such transfer is observed in subjects who score well only on the emotional dimension of interpersonal skills. Our findings open up a promising way to exploit cognitive talents in one domain in order to alleviate cognitive deficiencies elsewhere.
Peripheral Lymphocyte Count as a Surrogate Marker of Immune Checkpoint Inhibitor Therapy Outcomes in Patients with Non-Small-Cell Lung Cancer
Authors: Lee Ye Jin , Park Young Sik , Lee Hyun Woo , Park Tae Yun , Lee Jung Kyu , Heo Eun Young 
Published: June 2021

Abstract
BackgroundDegree of expression of programmed death-ligand 1 (PD-L1) is related with Immune check point inhibitors (ICIs) response but is not obligate predictive marker and needs sufficient tissue. Therefore, there is unmet need for easily accessible peripheral blood (PB) biomarkers and evaluation of the prognostic value of this marker is needed. We investigated the application of serum peripheral lymphocyte count (PLC) as a predictive PB biomarker for ICI response in patients with NSCLC. MethodsWe conducted a retrospective study and reviewed the medical charts of patients with NSCLC who were treated with ICIs at Seoul National University Hospital. We evaluated the association between PLC and progression-free survival using a Cox proportional hazard model. The PLC before and after 1 month of immunotherapy was collected. The quartile groups of PLC were compared using the Kruskal-Wallis statistical test.ResultsA total of 231 patients were treated with immunotherapy for NSCLC. The median follow-up period was 4.7 months. During the follow-up period, the disease progressed in 138 patients (59.7%). The post-treatment PLC groups Q2-4 showed significantly lower disease progression than group Q1 in our adjusted model (Q4 hazard ratio: 0.41, 95% confidence interval: 0.25–0.68, p < 0.001). The overall survival also showed similar results. An association between adverse events and PLC was not observed in this study. ConclusionWe revealed that an increased post-treatment PLC was associated with favorable progression-free and overall survival with NSCLC patients treated with ICIs. Therefore, PLC could be a surrogate marker for ICI responses in NSCLC.
The Curcumin Analog Da0324 Inhibits the Proliferation of Gastric Cancer Cells Via HOTAIRM1/miR-29b-1-5p/PHLPP1 Axis
Authors: Xu Fanfan , Chen Mengxia , Chen Hao , Wu Nan , Wang Ying , Dong Buyuan , Feng Qian , Jiang Lei , Jin Rong 
Published: June 2021

Abstract
Background

Our previous study has shown that Da0324, a curcumin analog, has significantly improved stability and antitumor activity. However, the molecular mechanisms of action of Da0324 remains poorly understood. Long non-coding RNA (lncRNA) has been certifed to play a key role in tumor progression. Here, we aim to investigate the molecular mechanisms underlying the anti-cancer activities of Da0324 through regulation of lncRNA HOTAIRM1.
Methods

Gastric cancer cell lines were treated with Da0324 and/or transfected with lentiviral vector expressing HOTAIRM1 shRNA, and/or miR-29b-1-5p mimics and/or small interference RNA (siRNA) against PHLPP1, or HOTAIRM1 siRNA or lentiviral vector expressing HOTAIRM1, as required. The expression of HOTAIRM1, miR-29b-1-5p and PHLPP1 in GC cells were determined by Real-Time PCR. Cell growth was examined by CCK-8 assay and colony formation assay in vitro. The targeted relationship between HOTAIRM1 and miR-29b-1-5p was verifed by luciferase reporter gene assay. Western blot was utilized to investigate PHLPP1 protein expression levels.
Results

Da0324 increased the expression of HOTAIRM1 in GC cells. HOTAIRM1 expression was significantly down-regulated in GC tissues, and the low expression of HOTAIRM1 was associated with the shorter survival rate of GC patients based on TCGA database. Knockdown of HOTAIRM1 promoted GC cell proliferation whereas overexpression of HOTAIRM1 inhibited GC cell proliferation as detected by CCK-8 and colony formation assays. Moreover, knockdown of HOTAIRM1 reversed the Da0324-mediated growth inhibition of GC cells. Furthermore, HOTAIRM1 acted as a sponge for miR-29b-1-5p and PHLPP1 is regulated by the HOTAIRM1/miR-29b-1-5p axis in GC cells. Overexpression of miR-29b-1-5p or knockdown of PHLPP1 reversed the ability of Da0324 to inhibit the growth of GC cells.
Conclusions

Our data suggest that Da0324 exerts antitumor activity by regulating HOTAIRM1/miR-29b-1-5p/PHLPP1 axis in GC cell, and provide new insights into the anti-cancer mechanism of Da0324.
Total Flavones Isolated from Lycium Barbarum L. Inhibit the Proliferation, Migration and Invasion of GlioblastomaU-87MG Cells by Decreasing Formyl Peptide Receptor 1 Expression
Authors: Chu Yuankui , Wang Qing , Li Yuan , Zhu Yating , Pang Baibin , Liao Guoling , Yang Hua 
Published: June 2021

Abstract
Background: To study the role and mechanisms of total flavones from Lycium barbarum L. (TFL) and FPR1 in the growth of glioblastoma U-87MG cells.Main Methods: CCK-8, wound-healing and Transwell were used for investigating proliferation, motility and invasion of U87 cells after treating with total flavones. RT-qPCR and Western blot were used to study the effect of total flavones on proliferating cell nuclear antigen (PCNA), matrix metalloproteinase2 (MMP2) and FPR1. The short hairpin RNA and FPR agonist fMLP were used to delineate the role of FPR1.Results: TFL was successfully isolated, and its concentration was determined to be 6.205 mg/l. TFL inhibited the proliferation, migration and invasion of U-87MG cells in a time and dose-dependent manner compared to controls. Decreasing FPR1 expression using short hairpin RNA significantly inhibited the migration and invasion of U-87MG cells. Notably, increased expression of FPR1 and treatment with FPR-agonist peptides such as N-formylmethionyl-leucyl-phenylalanine induced the migration and invasion of U-87MG cells, which was significantly decreased when the cells were treated with TFL. Conclusion: TFL inhibits the proliferation, migration and invasion of human glioblastoma U-87MG cells through decreasing the expression of FPR1. These findings provide valuable evidence for the development of antitumor drugs.