bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid halide perovskite neutron detectors
Authors: Andričević Pavao , Náfrádi Gábor , Kollár Márton , Náfrádi Bálint , Lilley Steven , Kinane Christy , Frajtag Pavel , Sienkiewicz Andrzej , Pautz Andreas , Horváth Endre , Forró László 
Published: August 2021

AbstractInterest in fast and easy detection of high-energy radiation (x-, γ-rays and neutrons) is closely related to numerous practical applications ranging from biomedicine and industry to homeland security issues. In this regard, crystals of hybrid halide perovskite have proven to be excellent detectors of x- and γ-rays, offering exceptionally high sensitivities in parallel to the ease of design and handling. Here, we demonstrate that by assembling a methylammonium lead tri-bromide perovskite single crystal (CH3NH3PbBr3 SC) with a Gadolinium (Gd) foil, one can very efficiently detect a flux of thermal neutrons. The neutrons absorbed by the Gd foil turn into γ-rays, which photo-generate charge carriers in the CH3NH3PbBr3 SC. The induced photo-carriers contribute to the electric current, which can easily be measured, providing information on the radiation intensity of thermal neutrons. The dependence on the beam size, bias voltage and the converting distance is investigated. To ensure stable and efficient charge extraction, the perovskite SCs were equipped with carbon electrodes. Furthermore, other types of conversion layers were also tested, including borated polyethylene sheets as well as Gd grains and Gd2O3 pellets directly engulfed into the SCs. Monte Carlo N-Particle (MCNP) radiation transport code calculations quantitatively confirmed the detection mechanism herein proposed.
Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
Authors: Schauer Paul A. , Rauh Jonas , Biedermann Sarah V. , Haaf Moritz , Steinmann Saskia , Leicht Gregor , Mulert Christoph 
Published: August 2021

AbstractPrevious studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced oscillatory activity in the theta frequency range in the EEG and altered activations in frontal and striatal regions in fMRI studies. The aim of the present study is to integrate these results using a coupling of simultaneously recorded EEG and fMRI. Simultaneous EEG (64-channel) and fMRI (3-Tesla Siemens Prisma) was recorded whilst participants (19 BPD patients and 18 controls) performed a gambling task. Data was analysed for the two imaging techniques separately as well as in a single-trial coupling of both modalities. Evoked theta oscillatory power as a response to loss feedback was reduced in BPD patients. EEG-fMRI coupling revealed an interaction between feedback valence and group in prefrontal regions centering in the dorsolateral prefrontal cortex (dlPFC), with healthy controls showing stronger modulation by theta responses during loss when compared to gain feedback and the opposite effect in BPD patients. Our results show multiple alterations in the processing of feedback in BPD, which were partly linked to impulsivity. The dlPFC was identified as the seed of theta-associated activation differences.
The importance of the UGT1A1 variants in the development of osteopenia and osteoporosis in postmenopausal women
Authors: Bogacz Anna , Kamiński Adam , Łochyńska Małgorzata , Uzar Izabela , Gorący Jarosław , Kotrych Daniel , Seremak-Mrozikiewicz Agnieszka , Czerny Bogusław 
Published: August 2021

AbstractThe UDP-glucuronosyltransferase 1A1 (UGT1A1) is involved in the process of estrogen conjugation and elimination. The aim of the study was to analyze whether the UGT1A1 genetic variants are associated with the development of osteopenia and osteoporosis in postmenopausal women. The analysis of the rs4148323 (UGT1A1*6) and rs3064744 (UGT1A1*28) variants in the UGT1A1 gene was conducted using real-time PCR. A significant correlation was observed between the genotypes of the rs3064744 (UGT1A1*28) sequence variant and body mass in women with osteoporosis. The analysis of the Z-score values revealed that women with osteoporosis and carrying the 6/6 variant had the lowest Z-score values as compared to women with the 6/7 and the 7/7 variants (− 1.966 ± 0.242 vs. − 1.577 ± 0.125 and − 1.839 ± 0.233). In addition, the odds ratio for the investigated genotypes (6/6, 6/7, 7/7) indicated an increased risk for osteopenia and osteoporosis in women with the 7/7 homozygous genotype. The analysis of the frequencies of the GG, GA and AA genotypes of the rs4148323 UGT1A1 gene showed no statistically significant differences between the groups. Our analysis revealed that the UGT1A1 rs3064744 variant may affect the risk of developing osteoporosis in postmenopausal Polish women. The UGT1A1 rs4148323 variant is not directly associated with the development of osteopenia and osteoporosis.
The impact of face masks on interpersonal trust in times of COVID-19
Authors: Malik Samreen , Mihm Benedikt , Reichelt Malte 
Published: August 2021

AbstractDespite the widespread use of face masks to combat COVID-19, little is known about their social and behavioral consequences. To understand the impact of face masks on interpersonal trust, we designed a novel experiment to assess the causal impact of face mask use on whether individuals follow economically relevant advice from a stranger. From a survey of more than 2000 US citizens, conducted during July and August 2020, we find that almost 5% fewer individuals trust advice when it is given by someone wearing a mask than when it is given by someone not wearing a mask. While, surprisingly, health-related risks do not seem to alter the way masks affect trust, the effects of masks are particularly large among individuals whose households face economic risks due to COVID-19 and those with below-average normative beliefs about mask wearing. Our results highlight the non-health-related meaning that face masks have developed during COVID-19 and suggest that mask use undermines trust in others among a substantial share of the US population.
Weakly supervised underwater fish segmentation using affinity LCFCN
Authors: Laradji Issam H. , Saleh Alzayat , Rodriguez Pau , Nowrouzezahrai Derek , Azghadi Mostafa Rahimi , Vazquez David 
Published: August 2021

AbstractEstimating fish body measurements like length, width, and mass has received considerable research due to its potential in boosting productivity in marine and aquaculture applications. Some methods are based on manual collection of these measurements using tools like a ruler which is time consuming and labour intensive. Others rely on fully-supervised segmentation models to automatically acquire these measurements but require collecting per-pixel labels which are also time consuming. It can take up to 2 minutes per fish to acquire accurate segmentation labels. To address this problem, we propose a segmentation model that can efficiently train on images labeled with point-level supervision, where each fish is annotated with a single click. This labeling scheme takes an average of only 1 second per fish. Our model uses a fully convolutional neural network with one branch that outputs per-pixel scores and another that outputs an affinity matrix. These two outputs are aggregated using a random walk to get the final, refined per-pixel output. The whole model is trained end-to-end using the localization-based counting fully convolutional neural network (LCFCN) loss and thus we call our method Affinity-LCFCN (A-LCFCN). We conduct experiments on the DeepFish dataset, which contains several fish habitats from north-eastern Australia. The results show that A-LCFCN outperforms a fully-supervised segmentation model when the annotation budget is fixed. They also show that A-LCFCN achieves better segmentation results than LCFCN and a standard baseline.
A comparative recombination analysis of human coronaviruses and implications for the SARS-CoV-2 pandemic
Authors: Pollett Simon , Conte Matthew A. , Sanborn Mark , Jarman Richard G. , Lidl Grace M. , Modjarrad Kayvon , Maljkovic Berry Irina 
Published: August 2021

AbstractThe SARS-CoV-2 pandemic prompts evaluation of recombination in human coronavirus (hCoV) evolution. We undertook recombination analyses of 158,118 public seasonal hCoV, SARS-CoV-1, SARS-CoV-2 and MERS-CoV genome sequences using the RDP4 software. We found moderate evidence for 8 SARS-CoV-2 recombination events, two of which involved the spike gene, and low evidence for one SARS-CoV-1 recombination event. Within MERS-CoV, 229E, OC43, NL63 and HKU1 datasets, we noted 7, 1, 9, 14, and 1 high-confidence recombination events, respectively. There was propensity for recombination breakpoints in the non-ORF1 region of the genome containing structural genes, and recombination severely skewed the temporal structure of these data, especially for NL63 and OC43. Bayesian time-scaled analyses on recombinant-free data indicated the sampled diversity of seasonal CoVs emerged in the last 70 years, with 229E displaying continuous lineage replacements. These findings emphasize the importance of genomic based surveillance to detect recombination in SARS-CoV-2, particularly if recombination may lead to immune evasion.
N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21
Authors: Toshikawa Hiromitsu , Ikenaka Akihiro , Li Li , Nishinaka-Arai Yoko , Niwa Akira , Ashida Akira , Kazuki Yasuhiro , Nakahata Tatsutoshi , Tamai Hiroshi , Russell David W. , Saito Megumu K. 
Published: August 2021

AbstractDown syndrome (DS) is caused by the trisomy of chromosome 21. Among the many disabilities found in individuals with DS is an increased risk of early-onset Alzheimer's disease (AD). Although higher oxidative stress and an upregulation of amyloid β (Aβ) peptides from an extra copy of the APP gene are attributed to the AD susceptibility, the relationship between the two factors is unclear. To address this issue, we established an in vitro cellular model using neurons differentiated from DS patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs. Neurons differentiated from DS patient-derived iPSCs secreted more Aβ compared to those differentiated from the euploid iPSCs. Treatment of the neurons with an antioxidant, N-acetylcysteine, significantly suppressed the Aβ secretion. These findings suggest that oxidative stress has an important role in controlling the Aβ level in neurons differentiated from DS patient-derived iPSCs and that N-acetylcysteine can be a potential therapeutic option to ameliorate the Aβ secretion.
Tropical cyclones shape mangrove productivity gradients in the Indian subcontinent
Authors: Rasquinha Dina Nethisa , Mishra Deepak R. 
Published: August 2021

AbstractRecent literature on the impact of cyclones on mangrove forest productivity indicates that nutrient fertilizations aided by tropical cyclones enhance the productivity of mangrove forests. We probe the implications of these predictions in the context of Indian mangroves to propose potential future directions for mangrove research in the subcontinent. First, we look at the time series trend (2000–2020) in satellite-derived gross primary productivity (GPP) datasets for seven mangrove forests across the country’s coastline. Second, we compare seasonal changes in soil nutrient levels for a specific site to further the arguments proposed in the literature and investigate the role of potential drivers of mangrove productivity. We find overall increasing trends for GPP over the past two decades for all seven mangrove sites with seasonal fluctuations closely connected to the tropical storm activities for three sites (Bhitarkanika, Pichavaram, and Charao). Additionally, organic carbon and nitrogen levels showed no significant trend, but phosphorus levels were higher during the post-monsoon-winter period for Bhitarkanika. Our findings expand the predictions of previous studies that emphasized the role of storm-induced nutrient fluxes and freshwater supply as primary drivers of productivity gradients in mangroves. Our study provides insights on how mangrove productivity may change with fluctuating frequency and magnitude of cyclones under a changing climate, implying the need for more mechanistic studies in understanding the long-term impact on mangrove productivity in the region.
Holiday gatherings, mobility and SARS-CoV-2 transmission: results from 10 US states following Thanksgiving
Authors: Mehta Shruti H. , Clipman Steven J. , Wesolowski Amy , Solomon Sunil S. 
Published: August 2021

AbstractPublic health officials discouraged travel and non-household gatherings for Thanksgiving, but data suggests that travel increased over the holidays. The objective of this analysis was to assess associations between holiday gatherings and SARS-CoV-2 positivity in the weeks following Thanksgiving. Using an online survey, we sampled 7770 individuals across 10 US states from December 4–18, 2020, about 8–22 days post-Thanksgiving. Participants were asked about Thanksgiving, COVID-19 symptoms, and SARS-CoV-2 testing and positivity in the prior 2 weeks. Logistic regression was used to identify factors associated with SARS-CoV-2 positivity and COVID-19 symptoms in the weeks following Thanksgiving. An activity score measured the total number of non-essential activities an individual participated in the prior 2 weeks. The probability of community transmission was estimated using Markov Chain Monte Carlo (MCMC) methods. While 47.2% had Thanksgiving at home with household members, 26.9% had guests and 25.9% traveled. There was a statistically significant interaction between how people spent Thanksgiving, the frequency of activities, and SARS-CoV-2 test positivity in the prior 2 weeks (p < 0.05). Those who had guests for Thanksgiving or traveled were only more likely to test positive for SARS-CoV-2 if they also had high activity (e.g., participated in > one non-essential activity/day in the prior 2 weeks). Had individuals limited the number and frequency of activities post-Thanksgiving, cases in surveyed individuals would be reduced by > 50%. As travel continues to increase and the more contagious Delta variant starts to dominate transmission, it is critical to promote how to gather in a “low-risk” manner (e.g., minimize other non-essential activities) to mitigate the need for nationwide shelter-at-home orders.
Photobiomodulation as an antioxidant substitute in post-thawing trauma of human stem cells from the apical papilla
Authors: Choi Woori , Baik Ku Youn , Jeong Seung , Park Sangbae , Kim Jae Eun , Kim Hong Bae , Chung Jong Hoon 
Published: August 2021

AbstractCryopreservation, the most common method of preserving stem cells, requires post-processing because it produces trauma to the cells. Post-thawing trauma typically induces cell death, elevates reactive oxygen species (ROS) concentration, and lowers mitochondrial membrane potential (MMP). Although this trauma has been solved using antioxidants, we attempted to use photobiomodulation (PBM) instead of chemical treatment. We used a 950-nm near-infrared LED to create a PBM device and chose a pulsed-wave mode of 30 Hz and a 30% duty cycle. Near-infrared radiation (NIR) at 950 nm was effective in reducing cell death caused by hydrogen peroxide induced-oxidative stress. Cryodamage also leads to apoptosis of cells, which can be avoided by irradiation at 950 nm NIR. Irradiation as post-processing for cryopreservation had an antioxidant effect that reduced both cellular and mitochondrial ROS. It also increased mitochondrial mass and activated mitochondrial activity, resulting in increased MMP, ATP generation, and increased cytochrome c oxidase activity. In addition, NIR increased alkaline phosphatase (ALP) activity, a biomarker of differentiation. As a result, we identified that 950 nm NIR PBM solves cryodamage in human stem cells from the apical papilla, indicating its potential as an alternative to antioxidants for treatment of post-thawing trauma, and further estimated its mechanism.
The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity
Authors: Carruthers Nicholas J. , Strieder-Barboza Clarissa , Caruso Joseph A. , Flesher Carmen G. , Baker Nicki A. , Kerk Samuel A. , Ky Alexander , Ehlers Anne P. , Varban Oliver A. , Lyssiotis Costas A. , Lumeng Carey N. , Stemmer Paul M. , O’Rourke Robert W. 
Published: August 2021

AbstractDysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis was to identify genes and proteins regulated by DM to elucidate aberrant cellular metabolic and signaling mediators. We performed label-free proteomics and RNA-sequencing analysis of VAT from female bariatric surgery subjects with DM and without DM (NDM). We quantified 1965 protein groups, 23 proteins, and 372 genes that were differently abundant in DM vs. NDM VAT. Proteins downregulated in DM were related to fatty acid synthesis and mitochondrial function (fatty acid synthase, FASN; dihydrolipoyl dehydrogenase, mitochondrial, E3 component, DLD; succinate dehydrogenase-α, SDHA) while proteins upregulated in DM were associated with innate immunity and transcriptional regulation (vitronectin, VTN; endothelial protein C receptor, EPCR; signal transducer and activator of transcription 5B, STAT5B). Transcriptome indicated defects in innate inflammation, lipid metabolism, and extracellular matrix (ECM) function, and components of complement classical and alternative cascades. The VAT proteome and transcriptome shared 13 biological processes impacted by DM, related to complement activation, cell proliferation and migration, ECM organization, lipid metabolism, and gluconeogenesis. Our data revealed a marked effect of DM in downregulating FASN. We also demonstrate enrichment of complement factor B (CFB), coagulation factor XIII A chain (F13A1), thrombospondin 1 (THBS1), and integrins at mRNA and protein levels, albeit with lower q-values and lack of Western blot or PCR confirmation. Our findings suggest putative mechanisms of VAT dysfunction in DM.
Electrical and optical properties of transition metal dichalcogenides on talc dielectrics
Authors: Nutting Darren , Prando Gabriela A. , Severijnen Marion , Barcelos Ingrid D. , Guo Shi , Christianen Peter C. M. , Zeitler Uli , Galvão Gobato Yara , Withers Freddie 
Published: August 2021

We find significant optical and electronic enhancements of transition metal dichalcogenides on talc dielectrics compared to SiO2 substrates, making talc dielectrics promising for future van der Waals optoelectronics.
On the secrecy outage analysis of underlay cognitive radio systems with buffer‐aided relaying under Nakagami‐m channels
Authors: Saber Mohammad Javad , Naseri Mohsen , Sadough Seyed Mohammad Sajad 
Published: August 2021

AbstractIn this work, the physical layer security performance of an underlay cognitive buffer‐aided relay network over the general Nakagami‐m fading channel model is addressed, where a primary source communicates with a destination via a decode‐and‐forward relay node in the presence of an eavesdropper and a secondary communication system. The relay is equipped with a finite‐size storage equipment or buffer which can store the sequence of received data packets from source and forward it immediately or subsequently in an adequate time‐slot. In this way, the buffer relay enables to adopt a link selection scheme in order to detect the best available link, (i.e. the one with higher secrecy rate) among the available data at source or at the relay buffer. The closed‐form expression for the secrecy outage probability (SOP), which is a widely adopted performance metric in the considered scenario, is also derived. Numerical results confirm the accuracy of the derived closed‐form analytic expression for SOP and indicates the interaction between secrecy performance and the Nakagami channel parameter m. In particular, it is shown that the SOP experiences a significant drop as the Nakagami channel parameter increases for a predefined target secrecy rate.
Broich, Fränkel und Harke: Geschichte des deutschen rhinologischen Beitrags zur Nasenspülung
Authors: Loennecken Iver Christian 
Published: August 2021

ZusammenfassungAnhand der frei verfügbaren Literatur wird die Entwicklung der Nasenspüler nach Broich, Fränkel und Harke dargestellt. Es wird dabei auf die Nasenspülung als Therapiemaßnahme, die dabei verwendeten Therapeutika und die persönliche Geschichte der jeweiligen Entwickler eingegangen.
Psychophysiologie der Körperhaltung
Authors: Behrens Nicolas 
Published: August 2021

SummaryDie Psyche drückt sich in der Körperhaltung aus– und ist umgekehrt vom Körper zu beeinflussen. Die Muskeln dienen nicht nur der Bewegung und der dynamischen Stabilisation von Rumpf und Extremitäten, sondern sind mit ihren Rezeptoren auch die Basis unserer Eigenwahrnehmung, der Propriozeption. Sie speichern zudem Emotionen, mit denen wir nicht umgehen konnten, und dienen der Kommunikation.Auffälligkeiten der Haltung und von Bewegungsabläufen können Therapeuten somato-psychisch verstehen und analysieren. Das System der Akupunktur mit den durch zugehörige Räume und Themen erweiterten Leitbahnachsen ist eine sinnvolle Übersetzungshilfe. Mögliche Therapieoptionen, die den Menschen in seiner inneren Entwicklung und Aufrichtung zu unterstützen, wie zum Beispiel die Akupunktur, aber auch das Kinesio-Taping, bis hin zu körperorientierten Therapieverfahren werden angesprochen.
Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature
Authors: Silva Patrícia Isabel Pereira , Perez Miriam 
Published: August 2021

AbstractFetal growth restriction (FGR) occurs when the fetus does not reach its intrauterine potential for growth and development as a result of compromise in placental function. It is a condition that affects 5 to 10% of pregnancies and is the second most common cause of perinatal morbidity and mortality. Children born with FGR are at risk of impaired neurological and cognitive development and cardiovascular or endocrine diseases in adulthood. The purpose of the present revision is to perform a literature search for evidence on the detection and assessment by ultrasound of brain injury linked to FGR during fetal life. Using a systematic approach and quantitative evaluation as study methodology, we reviewed ultrasound studies of the fetal brain structure of growth-restricted fetuses with objective quality measures. A total of eight studies were identified. High quality studies were identified for measurement of brain volumes; corpus callosum; brain fissure depth measurements, and cavum septi pellucidi width measurement. A low-quality study was available for transverse cerebellar diameter measurement in FGR. Further prospective randomized studies are needed to understand the changes that occur in the brain of fetuses with restricted growth, as well as their correlation with the changes in cognitive development observed.