bluuebunny/crossref_metadata_2025_split huggingface dataset:
A compact wideband high-gain circularly polarized array antenna based on SIGW-SRP
Authors: Chen Pengpeng , Wang Wenjian , Wang Lihui , Lin Qiuhua , Hou Da , Luo Zhiyong 
Published: December 2024

Abstract
A compact, wideband, and high-gain circularly polarized array antenna is proposed based on substrate integrated gap waveguide (SIGW) using sequential rotational phase (SRP). The array antenna consists of four

$2\times2$

corner-cutting corner patches and an SIGW-SRP feeding network. The SIGW-SRP feeding network is achieved by utilizing the spatial vector addition property to compensate for phase, aiming to improve the bandwidth and gain. Unlike the traditional SRP feeding network, the proposed feeding scheme is simpler and easier to fabricate, and each port can achieve more stable phase and bandwidth. In addition, benefiting from the surface wave suppression and in-phase reflection property of SIGW, the proposed array antenna has a stable radiation pattern and low cross-polarization covering wideband frequencies. The measured results indicate that the −10-dB impedance bandwidth ranges from 12.2 to 17.3 GHz (34.6%), the 3-dB axial ratio bandwidth ranges from 13.5 to 16.7 GHz (21.2%), and the peak gain is 16 dBic.
Entwicklung einer web-basierten Plattform zur formativen und feedback-gestützten Evaluation der ambulanten Routineversorgung Systemischer Psychotherapie (SysDok)
Authors: Hunger-Schoppe Christina , Evers Oliver , Baumeister Harald , Braus Niels , Eiler Sandro , Fendel Johannes C. , Hermans Björn Enno , Meßner Eva-Maria , Ochs Matthias , Portenhauser Alexandra , Terhorst Yannik , Schmidt Stefan 
Published: December 2024

Zusammenfassung: Theoretischer Hintergrund: Die Systemische Therapie ist Teil der psychotherapeutischen Routineversorgung für Erwachsene, Kinder und Jugendliche in Deutschland. Jedoch existiert kein standardisiertes Instrumentarium zu ihrer Qualitätssicherung. Fragestellung: Wie kann eine regelmäßige, niedrigschwellige und ökonomische Befragung (Routine Outcome Monitoring, ROM) konzipiert und in die systemtherapeutische Versorgungslandschaft implementiert werden? Methode: Die webbasierte Plattform SysDok nutzt klassische und computeradaptive Testverfahren. Erhoben werden Daten von Klient_innen, wichtigen Bezugspersonen und Therapeut_innen in systemtherapeutischen Ambulanzen. Ergebnisse: Ein altersspannenübergreifendes Messinventar dient der Informationssammlung im Erwachsenen-‍, Kinder- und Jugendlichenbereich ab dem 12. Lebensjahr und erfasst das psychische (PROMIS), systembezogene (EXIS, EVOS) und allgemeine Funktionsniveau (ERI, EQ-5D-5L), negative Erfahrungen durch Psychotherapien (INEP) sowie die therapeutische Allianz (WAI). Schlussfolgerung: SysDok zeigt sich vielversprechend in der zukünftigen Sicherstellung einer qualitativ hochwertigen Routineversorgung und mit Blick auf eine zukünftig personalisierte systemtherapeutische Versorgung („Precision Medicine“).
Breast cancer brain metastases genomic profiling identifies alterations targetable by immune-checkpoint and PARP inhibitors
Authors: Giannoudis A. , Sokol E. S. , Bhogal T. , Ramkissoon S. H. , Razis E. D. , Bartsch R. , Shaw J. A. , McGregor K. , Clark Alison , Huang R.S.P. , Palmieri C. 
Published: December 2024

AbstractUnderstanding the genomic landscape of breast cancer brain metastases (BCBMs) is key to developing targeted treatments. In this study, targetable genomic profiling was performed on 822 BCBMs, 11,988 local breast cancer (BC) biopsies and 15,516 non-central nervous system (N-CNS) metastases (all unpaired samples) collected during the course of routine clinical care by Foundation Medicine Inc (Boston, MA). Clinically relevant genomic alterations were significantly enriched in BCBMs compared to local BCs and N-CNS metastases. Homologous recombination deficiency as measured by BRCA1/2 alteration prevalence and loss-of-heterozygosity and immune checkpoint inhibitor (ICI) biomarkers [Tumor mutation burden (TMB)-High, Microsatellite instability (MSI)-High, PD-L1/L2)] were significantly more prevalent in BCBM than local BC and N-CNS. High PD-L1 protein expression was observed in ER-negative/HER2-negative BCBMs (48.3% vs 50.0% in local BCs, 21.4% in N-CNS). Our data highlights that a high proportion of BCBMs are potentially amenable to treatment with targeted therapeutic agents including PARP inhibitors and ICIs.
ACSL3 is an unfavorable prognostic marker in cholangiocarcinoma patients and confers ferroptosis resistance in cholangiocarcinoma cells
Authors: Sae-Fung Apiwit , Vinayavekhin Nawaporn , Fadeel Bengt , Jitkaew Siriporn 
Published: December 2024

AbstractCholangiocarcinoma (CCA) is a bile duct malignancy. Our previous comprehensive analysis showed that ferroptosis-related genes can stratify CCA patients into low-risk and high-risk groups based on survival time. Here, we explored the role of ferroptosis in CCA by analyzing mRNA expression in CCA patients from public databases. We identified acyl-CoA synthetase long chain family member 3 (ACSL3) as a potential ferroptosis suppressor in high-risk CCA patients. Using a panel of CCA cell lines, we confirmed ACSL3 upregulation in CCA cell lines associated with high-risk CCA, correlating this with resistance to the ferroptosis inducer RSL3. Lipidomic analysis revealed increased monounsaturated fatty acid (MUFA)-containing phospholipids in resistant cell lines. ACSL3 silencing sensitized these cells to RSL3. Resistance to ferroptosis was also dependent on exogenous MUFAs and was enhanced by lipid droplet biogenesis inhibition. These findings highlight ACSL3 as a promising target for therapeutic strategies aimed at overcoming ferroptosis resistance in CCA.
Skin layer-specific spatiotemporal assessment of micrometabolism during wound angiogenesis
Authors: Li Weiye , Liu Yu-Hang , Kubo Fumimasa , Werner Sabine , Razansky Daniel 
Published: December 2024

AbstractProper oxygen delivery through the microvasculature to injury site is essential to ensure the metabolic cascade during wound healing. Adaptation of vascular structure and oxygenation is key to unravel the regulation of blood perfusion, oxygen distribution and new tissue formation. Yet, visualizing micrometabolic responses at large scale in unperturbed living tissue remains challenging. We studied full-thickness excisional wounds in the mouse dorsal skin in vivo using ultrasound-aided spectroscopic large-scale optoacoustic microscopy. Skin layer-specific vascularization is visualized at capillary resolution over centimeter-scale field-of-view in a non-invasive, label-free manner. Different vascular parameters, including oxygenation, diameter and its irregularity, tortuosity and angular alignment, show distinct spatial and temporal variations. Elevated oxygenation is manifested close to the wound at day 4 with the trend accompanied by reduction in diameter over time. Angular alignment increases over time, indicating a more directed blood supply towards the wound. Our observations indicate that wound angiogenesis initiates as capillary sprouting with enlarged newborn vessels and elevated oxygenation around the wound, with the vessels normalizing in size and oxygenation during remodeling. Our study provides insight into micrometabolic profiles surrounding the healing wound, setting the stage for preclinical studies on oxygen delivery mechanisms in pathological skin conditions and during pharmacological interventions.
Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism
Authors: Bordes Joeri , Bajaj Thomas , Miranda Lucas , van Doeselaar Lotte , Brix Lea Maria , Narayan Sowmya , Yang Huanqing , Mitra Shiladitya , Kovarova Veronika , Springer Margherita , Kleigrewe Karin , Müller-Myhsok Bertram , Gassen Nils C. , Schmidt Mathias V. 
Published: December 2024

AbstractEarly life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation. Employing innovative unsupervised behavioral classification, the current study reveals distinct behavioral patterns associated with fear acquisition and retrieval in male and female mice following ELS. Females exposed to LBN display heightened active fear responses, contrasting with males. Furthermore, the study examined the crucial link between behavioral regulation and cellular metabolism in key brain regions involved in fear and stress processing. Sex-specific and stress-dependent alterations were observed in purine, pyrimidine, and glutamate metabolism within the basolateral amygdala, the dorsal hippocampus, and the ventral hippocampus. These findings provide crucial insights into the complex interplay between metabolic pathways, the neurobiological underpinnings of fear memory, and stress responses. Importantly, they emphasize the significance of considering sex-specific metabolic alterations when investigating stress-related disorders, opening potential avenues for the development of targeted interventions.
Indian Ocean Dipole intensifies Benguela Niño through Congo River discharge
Authors: McPhaden Michael J. , Jarugula Sreelekha , Aroucha Léo C. , Lübbecke Joke F. 
Published: December 2024

AbstractBenguela Niños are episodes of unusual El Niño-like warming in the upwelling zone off the coast of southwest Africa, with consequential impacts on marine ecosystems, coastal fisheries and regional weather. The strongest Benguela Niño in the past 40 years occurred in February–April 1995 with local sea surface temperature anomalies up to 4 °C off the coast of Angola and Namibia. Here, we show that a strong Indian Ocean Dipole in September–November 1994 helped boost the amplitude of the 1995 Benguela Niño through a land bridge involving Congo River discharge. We use atmospheric, oceanic, and hydrological data to demonstrate the sequential linkage between Indian Ocean Dipole development, unusually high rainfall in the Congo River basin, high Congo River discharge, low salinity near the Congo River mouth, and southward advection of this low salinity water into the Benguela upwelling region. The low salinity water isolated the surface mixed layer from the thermocline, which limited vertical mixing with colder subsurface waters and led to enhanced sea surface temperature warming. We also discuss how other Indian Ocean Dipole events may have similarly affected subsequent Benguela Niños and the possibility that Indian Ocean Dipole impacts on Benguela Niños may become more prominent in the future.
A spatiotemporal style transfer algorithm for dynamic visual stimulus generation
Authors: Greco Antonino , Siegel Markus 
Published: December 2024

Abstract
Understanding how visual information is encoded in biological and artificial systems often requires the generation of appropriate stimuli to test specific hypotheses, but available methods for video generation are scarce. Here we introduce the spatiotemporal style transfer (STST) algorithm, a dynamic visual stimulus generation framework that allows the manipulation and synthesis of video stimuli for vision research. We show how stimuli can be generated that match the low-level spatiotemporal features of their natural counterparts, but lack their high-level semantic features, providing a useful tool to study object recognition. We used these stimuli to probe PredNet, a predictive coding deep network, and found that its next-frame predictions were not disrupted by the omission of high-level information, with human observers also confirming the preservation of low-level features and lack of high-level information in the generated stimuli. We also introduce a procedure for the independent spatiotemporal factorization of dynamic stimuli. Testing such factorized stimuli on humans and deep vision models suggests a spatial bias in how humans and deep vision models encode dynamic visual information. These results showcase potential applications of the STST algorithm as a versatile tool for dynamic stimulus generation in vision science.
Causal effects of sedentary breaks on affective and cognitive parameters in daily life: a within-person encouragement design
Authors: Giurgiu Marco , Timm Irina , Ebner-Priemer Ulrich W. , Schmiedek Florian , Neubauer Andreas B. 
Published: December 2024

AbstractUnderstanding the complex relationship between sedentary breaks, affective well-being and cognition in daily life is critical as modern lifestyles are increasingly characterized by sedentary behavior. Consequently, the World Health Organization, with its slogan “every move counts”, emphasizes a central public health goal: reducing daily time spent in sedentary behavior. Previous studies have provided evidence that short sedentary breaks are feasible to integrate into daily life and can improve affective and cognitive parameters. However, observational studies do not allow for causal interpretation. To overcome this limitation, we conducted the first empirical study that integrated the within-person encouragement approach to test the causal effects of short 3-min sedentary breaks on affective and cognitive parameters in daily life. The results suggest that brief sedentary breaks may have a beneficial impact on valence and energetic arousal. Moreover, our methodological approach powerfully demonstrated the possibility of moving towards causal effects in everyday life.
Retour sur la constitution du concept d’épigénétique
Authors: Loison Laurent 
Published: December 2024

Encore aujourd’hui, l’épigénétique demeure un domaine de la biologie difficile à définir. Son essor spectaculaire depuis une vingtaine d’années s’est en effet parfois accompagné de discours radicaux, mettant en avant la fin du « tout génétique », voire l’insuffisance de la théorie darwinienne de l’évolution des espèces. Cet article souhaite revenir sur le moment de constitution du concept moderne d’épigénétique afin de montrer que, loin d’avoir été en rupture avec les savoirs acquis de la biologie, l’épigénétique doit être vue comme en parfaite continuité avec le développement de la génétique moléculaire. La nécessité de mécanismes épigénétiques a en effet été théorisée plusieurs décennies avant leur mise en évidence expérimentale.
Optimizing Irrigation and Fertilization Contributes to Mitigating Nutrients Leaching While Improving Crop Yield: Insights From a Field Experiment and Density Functional Theory Calculation
Authors: He Debo , Wang Yunfeng , Zang Yinlin , Wang Tao , Zhu Bo 
Published: December 2024

AbstractNitrogen (N) and phosphorus (P) losses from farmland pose a significant threat to non-point source pollution in plateau lakes. Reducing nutrient loss from cropland is essential for the sustainable agricultural and ecological development of plateau lakes. The study aimed to investigate the effects of optimizing irrigation and fertilization on N and P losses based on field experiments and density functional theory calculation. The findings showed that ditch irrigation contributes to N and P leaching through their interactions with water and colloids, while drip irrigation reduces the transfer capacity for N and P by decreasing the intensity and volume of leachates. Additionally, changing from conventional fertilization to multiple fertilization based on the nutrient needs of corn significantly improved fertilizer efficiency, resulting in reductions in N and P losses of 25.2–72.4% and 24.2–67.6%, respectively. Additionally, the optimization of irrigation and fertilization led to an 11.3% improvement in crop yield. These results contribute to a better understanding of the mechanisms through which agricultural practices affect nutrient losses and have significant implications for optimizing farmland management in the Erhai Lake basin. Importantly, this research is of great significance in mitigating the threat of agricultural non-point source pollution in ecologically fragile plateau lakes.
Liver Transplant for Nonhepatocellular Carcinoma Tumors: A Review of Expanding Indications in Nontraditional Transplant Oncology
Authors: Wehrle Chase J. , Fares Sami , Shanmugarajah Kumaran , Wakam Glenn , Calderon Esteban , Kusakabe Jiro , Satish Sangeeta , Linganna Maureen Whitsett , Khalil Mazhar , Pita Alejandro , Kim Jae-Keun , Fujiki Masato , Kwon David C.H. , Schlegel Andrea , Miller Charles , Hashimoto Koji , Aucejo Federico 
Published: December 2024

AbstractLiver transplantation (LT) is a life-saving procedure most well-known in the curative treatment of cirrhosis or end-stage liver disease. The approach is also well established for hepatocellular carcinoma (HCC) within Milan or other similar criteria. However, LT is increasingly utilized as the treatment for other primary and secondary liver cancers, including cholangiocarcinoma, colorectal cancer liver metastasis, neuroendocrine tumor, and angiosarcoma. We aim to review indications for LT for non-HCC hepatic malignancies.
Assessing Epilepsy Treatment Adherence and Factors Contributing to Adherence among People with Epilepsy in Paung Township
Authors: Oo San , Shwe Zarni Myint , Lin Htet Htet 
Published: December 2024

Abstract
Objective This study evaluates medication adherence among epilepsy patients at public health facilities in Paung Township, Mon State, Myanmar, using both quantitative and qualitative methods to explore influencing factors.
Methodology This cross-sectional study in Paung Township involved 72 epilepsy patients aged 12 years and older, receiving antiseizure medications for at least 6 months. Quantitative data were collected through questionnaires and the Morisky Medication Adherence Scale (MMAS-8), while qualitative insights were obtained from three focus group discussions involving patients and family members.
Results The study involved 72 people with epilepsy (PWE) in Paung Township, Myanmar, examining baseline characteristics, treatment services, perceptions, and adherence. The majority were young adults, and 87.5% lived in rural areas. Phenobarbital was the primary medication, and 94.4% received free medications. Most reported >50% seizure reduction and 75% attended follow-ups regularly. Overall, 59.7% demonstrated high adherence. Negative attitudes toward missing medication were prevalent among 90.3% of patients, and this was significantly associated with high adherence (p < 0.05). Family support (97.2%) and the convenience of accessing health facilities for medication were widely reported but did not show a significant association with the level of medication adherence. The qualitative findings affirmed satisfaction with health care services, minimal transportation challenges, reduced seizures, manageable side effects, and strong family support. Regular follow-ups significantly predicted adherence.
Conclusion Medication adherence among epilepsy patients in Paung Township was assessed using the MMAS-8, revealing high adherence in nearly 60% of participants. Regular follow-up appointments were significantly correlated with adherence, while negative attitudes toward missed doses and side effects influenced adherence. Patients expressed satisfaction with free medication services, convenience, and reduced seizure frequency.
Some problems involving Proto-Mǐn onsets and new Old Chinese
Authors: Smith Jonathan 
Published: December 2024

Abstract
The Mǐn languages are crucial for the study of early Chinese, and Baxter and
Sagart’s (2014) new Old Chinese system aims to prioritize Jerry Norman’s Proto-Mǐn of the 1970s. This report describes
three key problems relating to the reconstruction of Proto-Mǐn syllable onsets, observing that, in relation to each problem,
Baxter and Sagart’s new Old Chinese system is affected by serious errors with respect to data and methodology.
Anyway in Irish English
Authors: Hickey Raymond 
Published: December 2024

Abstract
The development of the pragmatic marker anyway in Irish English is of relatively recent date.
From an original adverb of manner there developed a pragmatic meaning when the element shifted to the right periphery (or became
exposed there through deletion of an element to the right of it). A transition period occurred during which varying
interpretations of anyway were possible, facilitating the rise of anyway as a pragmatic marker.
Later it appeared in the prosodically more prominent left periphery where anyway can only have a pragmatic
interpretation. The main theoretical insight of this study is that the discourse function arose from the ambiguous interpretation
of unqualified anyway. Importantly, a prosodic distinction arose between the two functions of
anyway with the discourse use showing considerably less stress on the final syllable [–weɪ] than the
syntactic use.
“Then we’re just two dudes driving around”
Authors: Vásquez Camilla , Akay Melike 
Published: December 2024

Abstract
App-mediated ride sharing services like Uber and Lyft represent a relatively new chronotope that shapes
participants’ identities and relationships through specific space and time configurations. Ridesharing services such as these blur
the boundaries between what is public/private, familiar/unfamiliar, and interactional/transactional, resulting in chronotopically
specific scenarios that are often humorously exploited by stand-up comedians in their routines. In this paper, we analyze several
short video clips of performances posted by comedians on TikTok comprising narratives about Uber/Lyft experiences from the
perspective of the ridesharing passenger. Our findings show that in these comedic performances the ridesharing chronotope is
characterized by various forms of relational ambiguity and that this relational ambiguity structures interactional frames for its
participants. Through their comedic artistry, comedians animate the diverse voices engaged in these types of encounters, shedding
light on variable norms and ideologies underlying ridesharing interactions. This study addresses a novel context and an as-yet
unexplored topic: the language used by stand-up comedians who make their performances available to audiences through their social
media accounts. Methodologically, the affordances of TikTok facilitate the identification of topically similar comedic content,
resulting in a topic-based, rather than a performer-driven, analysis.
Anisotropic mechanical properties and cushioning effectiveness of spruce subjected to different direction loading
Authors: Zhang Zexiong , Zhong Weizhou , Li Jiaxing , Luo Jingrun 
Published: December 2024

Abstract
The arrayed microstructure of wood produced during growth results in anisotropic mechanical behavior at the macroscopic level. In order to assess the cushioning effectiveness of spruce, the microstructural models with regular hexagonal array cells along axial, tangential, radial and 15°, 30°, 45°, 60°, 75° relative to the axial direction in tangential section were established. The mechanical responses of spruce along different loading directions were given by numerical simulations and experiments. The anisotropic mechanical properties and cushioning effectiveness of spruce were analyzed comparatively. Three prediction formulas were proposed to investigate the mechanical properties of spruce along different loading directions. The deformation characteristics, energy dissipation pattern and failure mechanism along different loading directions were given, and the influence of spruce microstructure on anisotropic mechanical behaviour with different direction were discussed.