bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Closer Examination of Relational Outcomes from a Pilot Study of Abbreviated, Intensive, Multi‐Couple Group Cognitive‐Behavioral Conjoint Therapy for PTSD with Military Dyads
Authors: Fredman Steffany J. , Le Yunying , Macdonald Alexandra , Monson Candice M. , Rhoades Galena K. , Dondanville Katherine A. , Blount Tabatha H. , Hall‐Clark Brittany N. , Fina Brooke A. , Mintz Jim , Litz Brett T. , Young‐McCaughan Stacey , Jenkins August I. C. , Yarvis Jeffrey S. , Keane Terence M. , Peterson Alan L. ,   for the Consortium to Alleviate PTSD
Published: April 2021

Cognitive‐behavioral conjoint therapy for posttraumatic stress disorder (CBCT for PTSD) is associated with improvements in patients’ PTSD symptoms, partners’ psychological distress, and relationship satisfaction. However, little is known about whether CBCT for PTSD is associated with changes in other relationship domains that have theoretical and clinical relevance to the relational context of PTSD. The current study is a secondary analysis of relational outcomes from an uncontrolled, within‐group trial designed to examine whether an abbreviated, intensive, multi‐couple group version of CBCT for PTSD (AIM‐CBCT for PTSD) delivered in a retreat during a single weekend was associated with improvements in PTSD symptoms and relationship satisfaction. In this investigation, we examined whether AIM‐CBCT for PTSD is also associated with improvements in ineffective arguing, supportive dyadic coping by partner, joint dyadic coping, and partners’ accommodation of patients’ PTSD symptoms. Participants were 24 couples who included a post‐9/11 U.S. service member or veteran with PTSD. At 1‐ and 3‐month follow‐up, patients reported significant reductions in couples’ ineffective arguing (ds = −.71 and −.78, respectively) and increases in supportive dyadic coping by partners relative to baseline (ds = .50 and .44, respectively). By 3‐month follow‐up, patients also reported significant increases in couples’ joint dyadic coping (d = .57), and partners reported significant reductions in their accommodation of patients’ PTSD symptoms (d = −.44). Findings suggest that AIM‐CBCT for PTSD is associated with improvements in multiple relationship domains beyond relationship satisfaction but that these may be differentially salient for patients and partners.
Increased targeted HIV testing and reduced undiagnosed HIV infections among gay and bisexual men
Authors: Patel PG , Keen P , McManus H , Duck T , Callander D , Selvey C , Power C , Gray RT , Knight V , Asselin J , Read P , Johnson K , Bavinton BR , Bowden VJ , Grulich AE , Guy R ,   the NSW HIV Prevention Partnership Project
Published: April 2021

ObjectivesTo evaluate the impact of government HIV strategies that aimed to increase HIV testing uptake and frequency among gay and bisexual men (GBM) in New South Wales (NSW), Australia.DesignWe analysed HIV testing data from existing passive and sentinel surveillance systems between 2010 and 2018.MethodsSix indicators were measured: (1) state‐wide total HIV laboratory tests; (2) number of GBM attending publicly‐funded clinics; (3) 12‐monthly testing uptake; (4) annual testing frequency; (5) HIV testing with a STI diagnosis; and (6) HIV positivity. Mathematical modelling was used to estimate (7) the proportion of men with undiagnosed HIV. Indicators were stratified by Australian vs. overseas‐born.ResultsOverall, 43,560 GBM attended participating clinics (22,662 Australian‐born, 20,834 overseas‐born) from 2010‐2018. Attendees increased from 5,186 in 2010 to 16,507 in 2018. There were increasing trends (p<0.001 for all) in testing uptake (83.9% to 95.1%); testing with a STI diagnosis (68.7% to 94.0%); annual HIV testing frequency (1.4 to 2.7); and a decreasing trend (p<0.01) in HIV positivity (1.7% to 0.9%).Increases in testing were similar in Australian‐born and overseas‐born GBM. However, there were decreasing trends in the estimated undiagnosed HIV proportion overall (9.5% to 7.7%) and in Australian‐born GBM (7.1% to 2.8%), but an increasing trend in overseas‐born GBM (15.3% to 16.9%) (p<0.001 for all).
International Council for Standardization in Haematology (ICSH) laboratory guidance for the verification of haemostasis analyser‐reagent test systems. Part 2: Specialist tests and calibrated assays
Authors: Gardiner Chris , Coleman Robyn , de Maat Moniek P. M. , Dorgalaleh Akbar , Echenagucia Marión , Gosselin Robert C. , Ieko Masahiro , Kitchen Steve 
Published: April 2021

AbstractBefore a new method is used for clinical testing, it is essential that it is evaluated for suitability for its intended purpose. This document gives guidance for the performance, verification and implementation processes required by regulatory and accreditation bodies. It covers the planning and verification of specialist haemostatic tests, including factor assays, D‐dimers, direct anticoagulants and thrombophilia testing.
The life history fitness of F1 hybrids of the microcrustaceans Daphnia pulex and Daphnia pulicaria (Crustacea, Anomopoda)
Authors: Moy Irene , Green Makayla , Pham Thinh Phu , Luu Dustin Huy‐Khang , Xu Sen 
Published: April 2021

AbstractNegative interaction between alleles that arise independently in diverging populations (i.e., Dobzhansky–Muller incompatibilities) can cause reduction of fitness in their hybrids. However, heterosis in hybrids can emerge if hybridization breaks down detrimental epistatic interaction within parental lineages. In this study, we examined the life history fitness of the interspecific F1s of two recently diverged microcrustacean species, Daphnia pulex and D. pulicaria, as well as intraspecific crosses of D. pulex. We identified heterosis in two of five life history traits in the interspecific F1s. According to theories that heterosis can transiently emerge in early speciation, the observation of heterosis in these life history traits suggests that there are no major genetic incompatibilities between these two species affecting these traits and that D. pulex and D. pulicaria are at an early stage of speciation.
Efficiency of whole‐exome sequencing in old world and new world primates using human capture reagents
Authors: Chan Jeannie , Yao Wen , Howard Timothy D. , Hawkins Gregory A. , Olivier Michael , Jorgensen Matthew J. , Cheeseman Ian H. , Cole Shelley A. , Cox Laura A. 
Published: April 2021

AbstractBackgroundWhole‐exome sequencing (WES) can expedite research on genetic variation in non‐human primate (NHP) models of human diseases. However, NHP‐specific reagents for exome capture are not available. This study reports the use of human‐specific capture reagents in WES for olive baboons, marmosets, and vervet monkeys.MethodsExome capture was carried out using the SureSelect Human All Exon V6 panel from Agilent Technologies, followed by high‐throughput sequencing. Capture of protein‐coding genes and detection of single nucleotide variants were evaluated.ResultsExome capture and sequencing results showed that more than 97% of old world and 93% of new world monkey protein coding genes were detected. Single nucleotide variants were detected across the genomes and missense variants were found in genes associated with human diseases.ConclusionsA cost‐effective approach based on commercial, human‐specific reagents can be used to perform WES for the discovery of genetic variants in these NHP species.
Subcutaneous emphysema after intralesional cryotherapy: An unusual complication
Authors: Falay Gür Tuğba , Savaş Erdoğan Sevil , Kara Cüneyt , Ertekin Sümeyre Seda 
Published: April 2021

AbstractBackgroundIntralesional cryotherapy (ILC) is a safe and well tolerated by the patient. Subcutaneous emphysema (SE) cases after spray and contact cryotherapy have been described; however, this complication has not been previously reported after ILC.AimOur aim is to discuss the possible causes of SE development after ILC.MethodWe present a young patient that developed SE after ILC applying by insertion of an open‐ended needle to the tip of the cryotherapy gun.ResultsThe development of SE following ILC may have been caused by inward clefting from the ear hole, the usage of an open‐ended needle and a lack of safety system.ConclusionIt will be safer to apply special methods involving the usage of sealed distal type to prevent SE development.
Stranger than a scorpion: a reassessment of Parioscorpio venator, a problematic arthropod from the Llandoverian Waukesha Lagerstätte
Authors: Anderson Evan P. , Schiffbauer James D. , Jacquet Sarah M. , Lamsdell James C. , Kluessendorf Joanne , Mikulic Donald G. 
Published: April 2021

AbstractA relatively uncommon arthropod of the Waukesha lagerstätte, Parioscorpio venator, is redescribed as an arthropod bearing a combination of characters that defy ready classification. Diagnostic features include sub‐chelate ‘great appendages’, a lack of antennae, multiramous anterior trunk appendages, filamentous fan‐like rear trunk appendages, and apparently thin and poorly preserved pleural fields. Phylogenetic analysis resolves this organism as basal to crown‐group Mandibulata and Chelicerata, but its exact placement is inconclusive. Thus, we compare its morphology to several stem groups of arthropods in a discussion of its plausible taxonomic affinities. The examined specimens are probably carcasses and preserve a variety of soft‐tissue details, including muscle blocks in the head, eyes and eye facets, likely ventral nerve cords, a central gut tract and trunk legs with multiple filamentous elements organized into stiff bundles. The preservation habits of P. venator are characterized and compared to previous assessments of Waukesha lagerstätte taxa. Four preservation habits are observed: a phosphatized habit showing flattened to partly three‐dimensional mineralization in francolite; a mouldic habit largely left behind by removed francolite that shows no carbon enrichment despite a darkened colour; sheet‐like or speckled carbonaceous compressions; and scattered pyrite crystals. This redescription highlights both the palaeobiological value of ‘small’ lagerstätten typical of the middle Palaeozoic and the caution that must be taken when interpreting their more enigmatic constituents.
Curcumin‐loaded Pluronic® F‐127 Micelles as a Drug Delivery System for Curcumin‐mediated Photodynamic Therapy for Oral Application
Authors: Dantas Lopes dos Santos Diego , Besegato João Felipe , de Melo Priscila Borges Gobbo , Oshiro Junior João Augusto , Chorilli Marlus , Deng Dongmei , Bagnato Vanderlei Salvador , Rastelli Alessandra Nara de Souza 
Published: April 2021

AbstractAntimicrobial photodynamic therapy (aPDT) is promising for oral decontamination. Curcumin has been used as photosensitizer; however, the hydrophobic properties can negatively affect aPDT. This study evaluated the aPDT efficacy using Cur‐loaded Pluronic® F‐127 micelles against Streptococcus mutans and Candida albicans biofilms. Micelles characterization was performed by zeta potential, dynamic light scattering, transmission electron microscopy, absorption and fluorescence spectroscopy. Cur concentrations, cell viability by CFU mL−1 and confocal microscopy were determined. Data were analyzed by parametric and nonparametric tests under 5%. Cur‐loaded Pluronic® F‐127 exhibited spherical shape, suitable particle size (≤100 nm), adequate polydispersity index, best stability, lower photodegradation and autoaggregation compared to unloaded‐Cur. Both microorganisms were sensitive to Cur‐loaded Pluronic® F‐127 micelles aPDT, with minimum inhibitory concentration (MIC) of 270 μm and 2.1093 μm for S. mutans and C. albicans suspended culture, respectively. Cur‐loaded Pluronic® F‐127 aPDT exhibited antibacterial/antifungal effect against the biofilms (~3 log10 reduction; P ≤ 0.05); however, similar to unloaded (P ≥ 0.05). Confocal images confirmed these results. Cur‐loaded Pluronic® F‐127 micelles exhibited good photo‐chemical properties and may be a viable alternative to deliver Cur and to improve aPDT effect during the treatment of dental caries. Moreover, Pluronic® micelles can enhance the solubility, stability, permeability and control the release of Cur.
Cardiorespiratory fitness, fatness, and the acute blood pressure response to exercise in adolescence
Authors: Huang Zhengzheng , Park Chloe , Chaturvedi Nish , Howe Laura D. , Sharman James E. , Hughes Alun D. , Schultz Martin G. 
Published: April 2021

ObjectiveExaggerated exercise blood pressure (BP) is associated with cardiovascular risk factors in adolescence. Cardiorespiratory fitness and adiposity (fatness) are independent contributors to cardiovascular risk, but their interrelated associations with exercise BP are unknown. This study aimed to determine the relationships between fitness, fatness, and the acute BP response to exercise in a large birth cohort of adolescents.Methods2292 adolescents from the Avon Longitudinal Study of Parents and Children (aged 17.8 ± 0.4 years, 38.5% male) completed a sub‐maximal exercise step test that allowed fitness (VO2 max) to be determined from workload and heart rate using a validated equation. Exercise BP was measured immediately on test cessation and fatness calculated as the ratio of total fat mass to total body mass measured by DXA.ResultsPost‐exercise systolic BP decreased stepwise with tertile of fitness (146 (18); 142 (17); 141 (16) mmHg) but increased with tertile of fatness (138 (15); 142 (16); 149 (18) mmHg). In separate models, fitness and fatness were associated with post‐exercise systolic BP adjusted for sex, age, height, smoking, and socioeconomic status (standardized β: −1.80, 95%CI: −2.64, −0.95 mmHg/SD and 4.31, 95%CI: 3.49, 5.13 mmHg/SD). However, when fitness and fatness were included in the same model, only fatness remained associated with exercise BP (4.65, 95%CI: 3.69, 5.61 mmHg/SD).ConclusionBoth fitness and fatness are associated with the acute BP response to exercise in adolescence. The fitness‐exercise BP association was not independent of fatness, implying the cardiovascular protective effects of cardiorespiratory fitness may only be realized with more favorable body composition.
Retracted: Transcription activation of microRNA‐25 by PEA3 augments progression of gastric cancer through suppressing SIK1
Authors: Yu Wei , Li Qingchun , Chen Tong , Zhang Huaiyu , Cui Xiaofeng , Shen Kexin 
Published: April 2021

Retraction: Yu, W., Li, Q., Chen, T., Zhang, H., Cui, X. and Shen, K. (2021), Transcription activation of microRNA‐25 by PEA3 augments progression of gastric cancer through suppressing SIK1. Exp Physiol. Accepted Author Manuscript. https://doi.org/10.1113/EP089254The above article, published online in Experimental Physiology on April 20, 2021 in Wiley Online Library (https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP089254) has been retracted by agreement between the journal's Editor‐in Chief Mike Tipton, the Authors and John Wiley & Sons Ltd. The authors requested withdrawal after an additional review of the data in the article showed inaccuracies in the data and its analysis.
Correlation Studies Between Laser Ultrasonic Inspection Data and Finite-Element Modeling Results in Evaluation of Solder Joint Quality in Microelectronic Packages
Authors: Reddy Vishnu V. B. , Gupta Saurabh , Williamson Jaimal , Sitaraman Suresh K. 
Published: April 2021

Abstract
Laser ultrasonic inspection (LUI) is a nondestructive and noncontact technique to evaluate the quality of solder ball interconnections in area-array micro-electronic packages. Dual-Fiber Array Laser Ultrasonic Inspection System was demonstrated identifying defects and failures in chip-scale packages, ball grid array packages, and flip-chip ball grid array packages. The location and severity of the defects and failures in packages have been identified accurately using this system. Further, it is important to establish the correlation between LUI results and the severity of the failures for failure mode analysis, which will enable us to eliminate the need for destructive testing and allow the study of failure evolution in a given sample under continued reliability testing. This paper discusses correlation studies between experimental LUI results and finite-element simulation results from the flip-chip ball grid array packages subjected to thermal cycling reliability testing. The correlation equations will help in predicting the severity of the failures at a given number of thermal cycles based on LUI results. Furthermore, the life of the micro-electronic packages can be predicted accurately from LUI results at a fewer number of thermal cycles.
Model-Aided Design of a Rear-Impact Collision Testing System for In Vivo Investigations
Authors: Barrett Jeff M. , Fewster Kayla M. , Callaghan Jack P. 
Published: April 2021

Abstract
A collision testing device used to simulate rear-end impacts on human volunteers was developed and validated. The testing device was designed using impact parameters obtained from real crash-test-derived vehicle-to-vehicle rear-end collisions. Experimental results show the proposed testing device achieves repeatable impact parameters well within the reported ranges of real vehicle-to-vehicle rear-end impact simulations reported in the literature. In particular, the device was able to produce a 7.66 (0.30) km/h delta-v collision with a duration of 111.6 (6.2) ms, and a 4.75 (0.29) g peak acceleration.
A Study on the Mechanisms of Change Propagation in Mechanical Design
Authors: Brahma Arindam , Wynn David C. 
Published: April 2021

Abstract
Design changes and change propagation have been recognized as ubiquitous in the engineering design process. But why are some design changes propagated while others are absorbed? This paper reports on a study to investigate the specific properties of a mechanical design that influence whether a change is either propagated or absorbed. Student participants in the study were asked to complete a well-defined mechanical design task and then to introduce several design changes. Analysis of the recorded design processes reveals new insight into the mechanisms of change propagation in terms of properties of the design. The insights suggest avenues for future research to make designs more tolerant to potential future change and to develop improved methods to predict change propagation.
Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study
Authors: Zghebi Salwa S , Mamas Mamas A , Ashcroft Darren M , Rutter Martin K , VanMarwijk Harm , Salisbury Chris , Mallen Christian D , Chew-Graham Caroline A , Qureshi Nadeem , Weng Stephen F , Holt Tim , Buchan Iain , Peek Niels , Giles Sally , Reeves David , Kontopantelis Evangelos 
Published: April 2021

ObjectiveMost current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD) and evaluated the association between severity and adverse outcomes.MethodsPrimary and secondary care data for 213 088 people with CHD in 398 practices in England between 2007 and 2017 were used. The cohort was randomly divided into training and validation datasets (80%/20%) for the severity model. Using 20 clinical severity indicators (each assigned a weight=1), baseline and longitudinal CVD severity scores were calculated as the sum of indicators. Adjusted Cox and competing-risk regression models were used to estimate risks for all-cause and cause-specific hospitalisation and mortality.ResultsMean age was 64.5±12.7 years, 46% women, 16% from deprived areas, baseline severity score 1.5±1.2, with higher scores indicating a higher burden of disease. In the training dataset, 138 510 (81%) patients were hospitalised at least once, and 39 944 (23%) patients died. Each 1-unit increase in baseline severity was associated with 41% (95% CI 37% to 45%, area under the receiver operating characteristics (AUROC) curve=0.79) risk for 1 year for all-cause mortality; 59% (95% CI 52% to 67%, AUROC=0.80) for cardiovascular (CV)/diabetes mortality; 27% (95% CI 26% to 28%) for any-cause hospitalisation and 37% (95% CI 36% to 38%) for CV/diabetes hospitalisation. Findings were consistent in the validation dataset.ConclusionsHigher CVD severity score is associated with higher risks for any-cause and cause-specific hospital admissions and mortality in people with CHD. Our reproducible score based on routinely collected data can help practitioners better prioritise management of people with CHD in primary care.
Interplay between Swampland and Bayesian Machine Learning in constraining cosmological models
Authors: Elizalde Emilio , Khurshudyan Martiros 
Published: April 2021

AbstractConstraints on a dark energy dominated Universe are obtained from an interplay Bayesian (Probabilistic) Machine Learning and string Swampland criteria. Unlike in previous studies, here, the field traverse itself has been used to constraint the theory and reveal its connection to the Swampland approach. The field traverse based Bayesian (Probabilistic) Learning approach is applied to two toy models. A parametrization of the Hubble constant is used for the first model, while a parametrization of the deceleration parameter is considered for the second one. The results obtained here allow to estimate how the high-redshift behavior of the Universe will affect the low-redshift one. Moreover, the adopted approach may highlight, in the future, the borders of the Swampland for the low-redshift Universe and help to develop new string-theory motivated dark energy models. The most important message from our study is a hint that the string Swampland criteria might be in tension with recent observations indicating that phantom dark energy cannot be in the Swampland. Finally, another interesting result obtained in our study is a spontaneous sign switch in the dark energy equation of state parameter when the field traverses are in the $$z\in [0,5]$$

z
∈
[
0
,
5
]

redshift range, a remarkable phenomenon requiring further analysis.
THE ESTIMATION OF RESPIRATION RATE BASED ON THE AMPLIFICATION OF RESPIRATION MOTION IN VIDEO
Authors: ZHANG CHI , LIU YUXIN , YUAN LIN , HOU XIAOXU 
Published: April 2021

Standard instrument for the clinical diagnosis of sleep apnea is large and based on invasive method, which is not comfortable and not suitable for daily inspection. A video-based measurement method for the respiration rate (RR) is therefore proposed, which is meaningful to the home diagnosis of sleep apnea. We proposed a novel method for the visualization and calculation of RR from a video containing a sleeping person. The video was decomposed by spatio-temporal Laplacian pyramid method into multiresolution image sequences, which were filtered by an infinite-impulse-response bandpass filter to extract the respiration movement in the video. The respiration movement was amplified, and fused into the original video. On the other hand, the signal intensity of the filtering results was compared between layers of Laplacian pyramid to identify the layer with the strongest movement caused by respiration. A morphological calculation was conducted on the image reshaped from the filtered results in this layer, to find the region of interest (ROI) with most significant movement of respiration. The image intensity in the ROI was spatially averaged into a one-dimensional signal, of which the frequency domain was analyzed to obtain RR. The ROI and the calculation results for RR were visualized on the video with enhanced respiration movement. Ten videos lasting 30–60[Formula: see text]s were recorded by a general webcam. The respiration movement of the subject was successfully extracted and amplified, no matter the posture was supine or side lying. The thoracic and abdominal parts were generally identified as ROI in all postures. RR was calculated by the frequency domain analysis for the averaged image intensity in ROI with the error no more than 1 time per minute, and further, as well as ROI, was fused into the amplified video. The region of respiration movement and RR is calculated by the noncontact method, and well visualized in a video. The method provides a novel screening tool for the population suspected of sleep apnea, and is meaningful to the home diagnosis of sleep illness.