bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venous thrombosis related to duplicated inferior vena cava: A case report and systematic review
Authors: Chen Chun , Huang Di-Sheng , Chang Kuo-Song , Lai Yen-Chun , Su Yu-Jang 
Published: February 2025

Rationale:
Swollen legs are commonly observed in clinical practice, and deep vein thrombosis (DVT) is 1 of the causes. Duplicated IVC (DIVC) is a relatively rare anomaly that results in DVT.

Patient concerns:
A 52-year-old male patient presented to the emergency department because of right leg swelling, pain, and redness for 3 days. His right leg was swollen from the sole to the thigh, with mild tenderness and local heat, without pitting edema.

Diagnoses:
Laboratory tests showed mild elevated C-reactive protein (CRP) 3.82 mg/dL (reference value: 0–0.79 mg/dL), and notably high levels of D-dimer (25,700 ng/mL; reference value: 0–653). Lower limb computed tomography angiography showed duplication of the IVC (DIVC) and was highly suspicious for venous thrombosis involving the right popliteal vein, superficial femoral vein, common femoral vein, external iliac vein, internal iliac vein, common iliac vein, and inferior vena cava (IVC).

Interventions:
Enoxaparin (80 mg) was administered subcutaneously, twice daily. After admission, catheter-directed thrombolysis and thrombectomy via the right superficial femoral and popliteal veins were performed.

Outcomes:
The congestion in the right lower leg improved, and the patient was discharged with rivaroxaban 15 mg twice daily 3 days later.

Lessons:
A systematic review using the keywords “duplication IVC,” “thrombosis” and “case report” was performed on PubMed until May 2023. Males accounted for 55.2% (16 of 29) of the cohort. The mean ± standard deviation age of the patients was 48.9 ± 17.9 years old. Pulmonary embolism was documented in 27.6% (8 29) of the cases. Regarding treatments, we found that 21 patients (72.4%) used anticoagulants, 20 patients (69.0%) received IVC filter placement, and 7 cases (24.1%) were treated by catheter-directed thrombolysis. Women had a higher proportion of popliteal vein and calf vein thrombosis, with a statistically significant difference (25% vs 61.5%, P = .047 < .05), (12.5% vs 53.8%, P = .017 < .05). The incidence of DIVC is around 0.3% to 0.7% with male predominance. A DIVC is a risk factor for DVT, especially in young people.
Current surgical management of malignant parotid tumors
Authors: Di Santo Davide , Deretti Alessandra , Vander Poorten Vincent 
Published: February 2025

Purpose of review
Surgical treatment of parotid cancer presents challenges due to the rarity of the disease, the histologic heterogeneity, and the complex regional anatomy. Recently published international guidelines contain recommendations for surgical management of the primary tumor and the neck lymph nodes, but still allow both T and N to be managed in different ways. This review summarizes the remaining areas of discussion.

Recent findings
The reference treatment for parotid cancer is total parotidectomy; however, for low-grade, low-stage tumors a superficial parotidectomy may be sufficient. The cN+ neck requires a comprehensive neck dissection; for cN0 multiple valuable options remain. Frozen section analysis on level II nodes can guide the extent of neck dissection. The definition of ‘clear margins’ remains debated; close margins in low-grade tumors appear to be acceptable, positive margins always require additional treatment.

Summary
A thorough understanding of the guidelines, fine-tuned if needed based on accurate preoperative workup and intraoperative surgeon's decision-making will provide the best outcome for the patient with parotid cancer.
Coupled Plasma Filtration and Adsorption in Eliminating Inflammatory Mediators and Enhancing Sublingual Microcirculation in Severe Acute Pancreatitis
Authors: Zhou# Hongli , Ma Chunjian , Zhong ShengNian 
Published: February 2025

Objective:
This study aims to assess the effectiveness of coupled plasma filtration and adsorption (CPFA) in patients with SAP through its effect on inflammatory mediators and sublingual circulating blood volume. The hypothesis put to test is that CPFA can achieve a satisfactory reduction in inflammatory mediators and enhance sublingual microcirculation in SAP with a very good clinical outcome.

Methods:
A cohort of 112 SAP patients admitted to the ICU of our institution between January 2018 and December 2022 was consecutively recruited. Participants were randomized to the CPFA or the control group (standard treatment) using a random number table for assignment. Post-treatment alterations in inflammatory mediators and sublingual microcirculation were analyzed and compared.

Results:
Following treatment, the study group showed significantly reduced levels of IL-1β, TNF-α, and IL-6 versus the control group. Additionally, the study group witnessed lower serum and urinary amylase levels and APACHE II and SOFA scores. Parameters related to sublingual microcirculation, including Total Vessel Density (TVDs), Small Vessel Perfusion Ratio (PPVs), Perfusion Small Vessel Density (PVDs), and Microvascular Flow Index (MFIs), were significantly improved in the study group. Moreover, the study group observed lower rates of Systemic Inflammatory Response Syndrome (SIRS) and 30-day mortality versus the control group.

Conclusion:
The application of CPFA in SAP patients effectively eliminates inflammatory mediators and enhances microcirculation, leading to improved clinical outcomes and reduced mortality rates.
Knowledge of breast cancer among nurses in a tertiary care center-a descriptive cross-sectional study
Authors: Shrestha Simangainda Deependra Man , Barma Aachal , Rawal Gunjana , Karn Mitesh , Bk Jeevan , Adhikari Jayaj 
Published: February 2025

Objective:
This study aims to assess the knowledge and awareness of breast cancer among nurses, a critical component of the healthcare workforce. While many previous studies have focused on female participants and students, this study specifically targets nurses working in a tertiary care center, given their crucial role in patient education, early cancer detection, and facilitating timely medical intervention.

Methods:
A descriptive cross-sectional study was conducted among 235 nurses working in the various departments of a tertiary care center from August to September 2021. Data on breast cancer knowledge were collected using structured questionnaires with knowledge levels categorized as “good” or “poor” using the median score as a cut-off. The validity and reliability of the questionnaire were ensured through expert review and pilot testing. Descriptive statistics were used to present the findings.

Results:
Our study revealed overall good knowledge (64.7% correct answers) about breast cancer among the study participants. Most participants (93.2%) were aged 18–29, and 72.3% held a PCL nursing qualification. Only half of the respondents recognized obesity and smoking as risk factors, with common misconceptions including the belief that nulliparity and alcohol consumption are not risks. While over 90% identified breast lumps and enlargement as symptoms, only half recognized non-lump symptoms like nipple discharge and skin changes. Participants were highly aware of breast cancer detection tools, with nearly all recognizing clinical breast exams, mammography, and breast ultrasound. About 75.7% knew of biopsy, and 74.5% mentioned MRI. Mammography was the most commonly recognized screening tool (95.7%).

Conclusion:
While general awareness of breast cancer is high among nurses, specific gaps remain regarding certain risk factors and symptoms, including obesity, smoking, and non-lump breast cancer indicators. Targeted education through workshops or continuous medical education programs could enhance nurses’ ability to effectively educate and screen patients.
A Breath of Fresh Air: Pilot Testing Electronic Case Reporting for Public Health Surveillance of Occupational Lung Diseases in Wisconsin
Authors: Creswell Paul D. , Mader Sara , Modji Komi K.S. , McCoy Katherine E. 
Published: February 2025

Context:
Public health surveillance plays a crucial role in evaluating disease risk and providing timely evidence to policymakers and the public. However, surveillance of many occupational diseases is limited by existing surveillance infrastructure, which is heavily dependent on laboratory tests.

Objective:
The present pilot study compared case data for 3 occupational lung diseases (ie, silicosis, asbestosis, and farmer’s lung disease) from electronic case reports (eCR) with existing hospital discharge data in the state of Wisconsin to see if eCR—which sends health records directly from clinics when specific criteria are met—provided previously undetected cases of these reportable diseases.

Design:
Case data for 3 reportable occupational lung diseases were pulled from eCR records within the Wisconsin Electronic Disease Surveillance System. In this retrospective cross-sectional study, a unique identifier was used to match eCR cases to hospital discharge data.

Setting and Participants:
This study was conducted using administrative data at a state health department to compare data systems and assess the utility of eCR for occupational health surveillance.

Main Outcome Measures:
The number and percentage of matched and unmatched cases were calculated to assess the overlap of the 2 data systems. For eCR cases, the median number of years since diagnosis was also assessed.

Results:
The percentage of eCR cases that could not be matched to hospital discharge data ranged from 55% to 81.2%, depending on the disease of interest. The median length of time since diagnoses for eCR cases was multiple years, suggesting that most had long been missing from existing surveillance.

Conclusions:
This study suggests that eCR creates new potential in occupational health surveillance. eCR was found to provide previously undetected cases of occupational lung disease at a state health department and stands to improve the timeliness of case reporting as well.
Catatonia in a Patient With Lissencephaly Treated With ECT
Authors: Mahgoub Yassir , Khalid Moyyed , Sosal Wafa , Pathare Aum 
Published: February 2025

Abstract
Catatonia is a neuropsychiatric syndrome that occurs with several psychiatric and systemic medical conditions. Central nervous system abnormalities are believed to increase the risk of catatonia, with several cases reported in patients with neurodevelopmental and neurodegenerative disorders. Lissencephaly is a spectrum of neuronal migration disorders characterized by poorly defined or absent gyri and sulci, abnormally thick cortex, and a broad array of histopathological changes. Lissencephaly has a range of etiologies, clinical signs, symptoms, and degrees of severity. It is associated with comorbidities, such as epilepsy, visual, cardiac, and skeletal problems, as well as premature mortality.
In this article, we describe the case of a patient with lissencephaly who developed catatonia at 20 years of age. He was minimally responsive to treatment with a high dose of lorazepam, and catatonia subsided with the use of electroconvulsive therapy. This is the first case in our knowledge to describe the occurrence of catatonia among patients with lissencephaly and its treatment with electroconvulsive therapy.
Trait-environment interactions influence tree planting success in Peruvian tropical dry forests
Authors: Goossens W. , Fremout T. , Muys B. , Soto Quispe J.C. , Van Meerbeek K. , Maes S.L. 
Published: February 2025

AbstractTropical dry forests are among the most endangered ecosystems globally, despite their critical socio-ecological importance. In recent decades, various tree-planting initiatives have been undertaken to restore these forests, yielding mixed results. To enhance restoration effectiveness, it is imperative to adopt a predictive approach, focussing on the drivers of seedling performance and their interactions. This study explores how tree species traits and environmental conditions interact to influence survival and growth rates in the Tumbes-Piura tropical dry forests of northwestern Peru. Our findings support the widely acceptedgrowth-mortalityhypothesis, indicating that acquisitive species characterised by a high specific leaf area and low wood density achieve faster growth but experience higher mortality compared to conservative species. According to the general resource-use theory, these acquisitive species are also more sensitive to variations in water and nutrient availability, showing steep declines in growth and survival rates as site conditions become less favourable. Interestingly, we found that thegrowth-mortalityhypothesis holds along environmental gradients, with acquisitive species maintaining their high growth rates even under resource-poor conditions, but at the cost of greater vulnerability to mortality. In contrast, the growth rates of conservative species increase markedly when water and nutrients become less limiting. These insights underscore the importance of considering trait-environment interactions in planning tree-planting projects and adapting the management strategy to overall restoration objectives. By doing so, we can improve the outcomes and sustainability of restoration efforts in tropical dry forests.Implications for practice-Thegrowth-mortalityhypothesis holds along resource gradients in tropical dry forest restoration.-Acquisitive species can exhibit high growth rates even in resource-poor sites, which comes at the cost of higher mortality. Increasing successful establishment through irrigation and fertilization will likely accelerate forest recovery in these restoration sites.-Planting conservative species in less favourable sites is a more viable option when economic resources are limited, offering a more certain, albeit slower, forest establishment without the need for intensive management.-Our findings highlight the importance of accounting for trait-environment interactions when evaluating restoration success in future studies.
A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy
Authors: Liu Rui , Weng Xun , Li Xinjing , Cao Yongheng , Li Qiyun , Luan Lin , Tong Danqing , Kong Zhaosheng , Wang Hao , Wang Taotao , Gong Qingqiu 
Published: February 2025

AbstractChloroplasts are major photosynthetic and protein-containing organelles in green plants and algae. Unwanted chloroplast proteins and entire chloroplasts are cleared through various degradation pathways including autophagy. Nevertheless, canonical chlorophagy receptors remain unidentified, and whether and to what extent chlorophagy can be enhanced to benefect the plants remain unknown. Here we designed and validated a synthetic chloroplast autophagy receptor using biochemical, genetical, and imaging approaches. This synthetic receptor, LIR-SNT-BFP, was constructed by fusing a fragment containing the LC3-interacting region (LIR) of the selective autophagy receptor NBR1 and the N-terminal amphipathic α-helix of the chloroplast outer envelope protein SFR2. The fusion protein LIR-SNT-BFP coated the chloroplast and attracted ATG8ain planta. Upon induction, the synthetic receptor elicited vacuole-mediated microautophagy of entire chloroplasts independent of the ATG8 conjugation machinery proteins ATG5 or ATG7. Meanwhile, it induced chloroplast division; however the induced chlorophagy was independent of PDV2. Notably, moderate chlorophagy improves rosette growth, but excessive levels are detrimental. Furthermore, induced chlorophagy partially protects against herbicide-induced leaf chlorosis. This study demonstrates controlled chloroplast degradation using a synthetic chlorophagy receptor.
The pgp1 Mutant Locus of Arabidopsis Encodes a Phosphatidylglycerolphosphate Synthase with Impaired Activity
Authors: Xu Changcheng , Härtel Heiko , Wada Hajime , Hagio Miki , Yu Bin , Eakin Chris , Benning Christoph 
Published: July 2002

Abstract
Phosphatidylglycerol is a ubiquitous phospholipid that is also present in the photosynthetic membranes of plants. Multiple independent lines of evidence suggest that this lipid plays a critical role for the proper function of photosynthetic membranes and cold acclimation. In eukaryotes, different subcellular compartments are competent for the biosynthesis of phosphatidylglycerol. Details on the plant-specific pathways in different organelles are scarce. Here, we describe a phosphatidylglycerol biosynthesis-deficient mutant of Arabidopsis, pgp1. The overall content of phosphatidylglycerol is reduced by 30%. This mutant carries a point mutation in the CDP-alcohol phosphotransferase motif of the phosphatidylglycerolphosphate synthase (EC 2.7.8.5) isoform encoded by a gene on chromosome 2. The mutant shows an 80% reduction in plastidic phosphatidylglycerolphosphate synthase activity consistent with the plastidic location of this particular isoform. Mutant plants are pale green, and their photosynthesis is impaired. This mutant provides a promising new tool to elucidate the biosynthesis and function of plastidic phosphatidylglycerol in seed plants.
An adaptive notch filtering approach with frequency holder for attitude control of flexible launch vehicles
Authors: He Xiao , Yang Jinzhao , Liu Yuxi , Hu Cunming , Tan Shujun 
Published: February 2025

Purpose
This study aims to investigate an adaptive notch filtering approach to suppress the effects of elastic vibration on the attitude control of flexible launch vehicles.

Design/methodology/approach
First, the dynamics model of the flexible launch vehicle and baseline PID controller are presented. Furthermore, the frequency identification algorithm based on a second-order notch filter is developed to identify the elastic vibration frequency. Finally, a frequency holder is developed to update the notch frequency of the adaptive notch filter.

Findings
The proposed adaptive notch filter with a frequency holder can identify the vibration frequency accurately, update the notch frequency appropriately and suppress the effects of the elastic vibration on the attitude control of flexible launch vehicles effectively.

Originality/value
A novel adaptive notch filter with a frequency holder is proposed to address the adaptive filtering problem of elastic vibrations under nonelastic interference and elastic frequency uncertainty. Compared with the conventional filter for attitude control of flexible launch vehicles, an adaptive filter with a proposed frequency holder is developed to solve the problem of the frequency real-time update during the vibration suppression and frequency keeping after the vibration suppression.
The physical geometries of sacred spaces: methodological challenges in applying practice-based approaches to study sacred shrines
Authors: Flint Ashery Shlomit , Stadler Nurit 
Published: February 2025

PurposeWhile the praxeological turn in social research has resulted in many empirical studies, there are few works utilizing this concept as a framework to analyze complex architectural–anthropological phenomena, in particular in sacred geographies. This study addresses this gap by integrating architectural and anthropological approaches to explore interactions between humans, non-humans and what are considered sacred environments.Design/methodology/approachIt presents case studies of the womb–tomb archetypes of Rabbi Zechariah and Rabbi Avdimi in northern Israel to demonstrate how ritualistic practices shape and are shaped by these structures that are deeply connected to human anatomy, lifecycles and territoriality.FindingsOur analysis uses isovist analysis to examine the spatial dynamics of sacred architectures, which is then applied to Navisworks Roamer 3D Viewer to estimate the materials from a sacred architectural–anthropological perspective that better reflects body movements and ritualistic performances.Research limitations/implicationsBased on our findings from interviews, observations and architectural measures, we reveal how these practices simultaneously articulate land as property—an exclusive, territorial claim rooted in religious and political narratives—and as connectivity, emphasizing relational ties that foster a sense of belonging and interdependence with the land.Practical implicationsThis duality is represented by the embodied gestures of bending, crawling and touching in these spaces, which establish both symbolic ownership and deep relationships with the environment.Social implicationsThe findings emphasize the importance of bodily engagements and narrative constructions in reimagining human–environment relationships and contribute to the broader discourse on practice-based boundary making approaches in architectural studies.Originality/valueThey also demonstrate how body-environment practices shape ongoing negotiations of land, belonging and totemic relationships within complex cultural landscapes.
Establishing smart system for building operation and maintenance using SOMCM algorithm
Authors: Chen Jieh-Haur , Su Mu-Chun , Lin Wei-Jen , Yu Tzuyang , Wu Kai-Yuan 
Published: February 2025

PurposeThe research objective is to establish a smart system for building operation and maintenance using self-organizing map-based cluster merging (SOMCM) algorithm.Design/methodology/approachThe process begins with a thorough literature review to establish the interface framework, followed by its design. An empirical study in Taoyuan City’s industrial park, involving 46 buildings and 3,526 maintenance records, informed development. By integrating the “Shared Facility Management System Equipment Repair Module” and the “Maintenance Management System for Existing Facilities,” 21 enhanced interface components were created. All work orders are stored in a database for aggregation, statistical analysis and clustering using the algorithm SOMCM, aiding repair decision-making.FindingsThe outcomes stemming from the proposed methodology culminate in the identification of seven patterns that can significantly enhance the efficiency of maintenance operations: (1) simplify current self-repair to outsourcing; (2) modify the current traditional contract type to open contract type; (3) adopt massive procurement for major facilities (e.g. air conditioning); (4) schedule power supply systems in a systematic and efficient way; (5) establish maintenance patterns as suggested to eliminate warehouse for spares; (6) reallocate maintenance resources in a seasonal cycle; (7) set up a standby team to resolve emergency repairs. The findings can reduce a significant amount of time and cost for the investigated industrial park.Originality/valueMaintenance work has faced delays, aging equipment has caused component damage, and park structures no longer meet operational needs. Addressing these challenges, the study introduces a novel SOMCM approach for smart building operation and maintenance. This approach emphasizes creating a user-friendly, practical system pivotal to platform success. By integrating demand-driven strategies, it enhances traditional maintenance processes and offers innovative solutions to operational and management issues, ensuring alignment with modern requirements and improved efficiency.