bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal 3D-Ultrasound Diagnosis of “Tessier 3” Lateral Facial Cleft
Authors: Krishnan Vivek , Thomas Mathew , Sharma Mohit , Elayedatt Rinshi Abid 
Published: December 2021

AbstractAtypical facial clefts are rare and result from partial or total non-fusion of embryonal craniofacial tissue. Tessier classified facial clefts and numbered them from 0 to 14, using the orbit as the primary structure of reference. The Tessier three cleft which extends through the upper lip, alar groove, and medial canthus is one of the most destructive of all facial clefts albeit one of the rarest. We report a case of isolated Tessier 3 facial cleft diagnosed on prenatal three-dimensional (3D) ultrasound examination. Two-dimensional sonography revealed a normally growing fetus with an absence of left alae nasi and normal appearing lips, palate, and alveolar ridges. However, a 3D imaging in surface rendering mode showed a large Tessier 3 lateral facial cleft, thus confirming the utility of 3D sonography in the prenatal diagnosis of such rare lateral facial clefts.
Continuous self-adaptive optimization to learn multi-task multi-agent
Authors: Liang Wenqian , Wang Ji , Bao Weidong , Zhu Xiaomin , Wang Qingyong , Han Beibei 
Published: December 2021

AbstractMulti-agent reinforcement learning (MARL) methods have shown superior performance to solve a variety of real-world problems focusing on learning distinct policies for individual tasks. These approaches face problems when applied to the non-stationary real-world: agents trained in specialized tasks cannot achieve satisfied generalization performance across multiple tasks; agents have to learn and store specialized policies for individual task and reliable identities of tasks are hardly observable in practice. To address the challenge continuously adapting to multiple tasks in MARL, we formalize the problem into a two-stage curriculum. Single-task policies are learned with MARL approaches, after that we develop a gradient-based Self-Adaptive Meta-Learning algorithm, SAML, that cannot only distill single-task policies into a unified policy but also can facilitate the unified policy to continuously adapt to new incoming tasks. In addition, to validate the continuous adaptation performance on complex task, we extend the widely adopted StarCraft benchmark SMAC and develop a new multi-task multi-agent StarCraft environment, Meta-SMAC, for testing various aspects of continuous adaptation method. Our experiments with a population of agents show that our method enables significantly more efficient adaptation than reactive baselines across different scenarios.
Disaggregating democracy aid to explain peaceful democratisation after civil wars
Authors: Mross Karina 
Published: December 2021

AbstractDemocratisation is hailed as a pathway to peace by some, yet, blamed for provoking renewed violence by others. Can democracy aid explain the effect of democratisation after civil war? Building upon findings that transitions to democracy are prone to violence, this article shows that external democracy aid can mitigate such negative effects. It is the first to disaggregate democracy aid and analyse its effect on peace after civil war. To this end, it uses a configurational approach and focuses on support for competition (for example, promoting free and fair elections), institutional constraints (for example, strengthening the judiciary), and cooperation (for example, facilitating reconciliation). Combining Qualitative Comparative Analysis (QCA) with an illustrative case study on Liberia, it demonstrates that democracy aid can help to prevent recurrence during postconflict democratisation. Two pathways can explain peaceful democratisation: first, fostering ‘cooperative democratisation’ characterised by substantial support for cooperation in lower-risk contexts; and second, fostering ‘controlled competition’ by combining substantial support for institutional constraints and competition. Importantly, democracy support does not trigger renewed violence. These findings speak to the academic debate on the destabilising potential of democratisation processes after civil wars and inform policymakers designing postconflict support strategies.
Expansion of the Low-Risk Substances in the Framework of the European Pesticide Regulation (EC) No 1107/2009
Authors: Robin Diane C. , Marchand Patrice A. 
Published: December 2021

AbstractSigned in 2009, the plant protection Commission Regulation EC No 1107/2009 created a new category of active substances, the low-risk substances, with specific status defined in Article 22. The initial and specific criteria, not suitable for microorganisms and natural substances, were modified in 2018, and the first low-risk substance, allocating Part D of Regulation EC No 540/2011, was granted in the same year. Since then, thirty-three low-risk substances have been granted with this specific status through approvals and renewals, while a larger list of potential low-risk substances from already-approved active substances was published. This list is only exploited during renewals, and this process would take another five years to complete. After four years of the implementation of this status, the number of such substances is still low, but is intended to increase slowly. Two more low-risk substances are already pending in 2021, which will bring the number of low-risk substances to thirty-five, while the initial list of potential low-risk substances (only renewals) included fifty-seven substances.
“Revolution is the Equality of Children and Adults”: Yaşar Kemal Interviews Street Children, 1975
Authors: Maksudyan Nazan 
Published: December 2021

AbstractIn 1975, the world-famous novelist Yaşar Kemal (1923–2015) undertook a series of journalistic interviews with street children in Istanbul. The series, entitled “Children Are Human” (Çocuklar İnsandır), reflects the author's rebellious attitude as well as the revolutionary spirit of hope in the 1970s in Turkey. Kemal's ethnographic fieldwork with street children criticized the demotion of children to a less-than-human status when present among adults. He approached children's rights from a human rights angle, stressing the humanity of children and that children's rights are human rights. The methodological contribution of this research to the history of children and youth is its engagement with ethnography as historical source. His research provided children the opportunity to express their political subjectivities and their understanding of the major political questions of the time, specifically those of social justice, (in)equality, poverty, and ethnic violence encountered in their everyday interactions with politics in the country. Yaşar Kemal's fieldwork notes and transcribed interviews also bring to light immense injustices within an intersectional framework of age, class, ethnicity, and gender. The author emphasizes that children's political agency and their political protest is deeply rooted in their subordination and misery, but also in their dreams and hopes. Situating Yaşar Kemal's “Children Are Human” in the context of the 1970s in Turkey, I hope to contribute to childhood studies with regard to the political agency of children as well as to the history of public intellectuals and newspapers in Turkey and to progressive representations of urban marginalization.
Molecular evidence of a putative new Atractolytocestus Anthony, 1958 (Cestoda: Caryophyllidea) species parasitic on common carp (Cyprinus carpio) in the People's Republic of China
Authors: Fu P.P. , Li W.X. , Cheng Y.Y. , Zou H. , Wu S.G. , Li M. , Wang G.T. 
Published: December 2021

Abstract
Three tapeworm species belonging to the genus Atractolytocestus Anthony, 1958 (Cestoda: Caryophyllidea) were reported from the common carp, Cyprinus carpio L., 1758 in the People's Republic of China so far: Atractolytocestus sagittatus; Atractolytocestus tenuicollis; and Atractolytocestus huronensis. In this study, we identified a putatively new tapeworm species in common carp from the Danjiangkou Reservoir in Central China (Hubei Province). The species is morphologically similar to A. sagittatus, but it differed conspicuously in sequences of three molecular markers. Ribosomal internal transcribed spacers 2 sequence identity of the new species was 94.7–95.5%, 91.8–92.7% and 80.0–83.9% with A. huronensis, A. tenuicollis and A. sagittatus, respectively. cytochrome c oxidase and NADH dehydrogenase subunit 3 sequence identity with these three species was lower than 92%. We conclude that this is a new tapeworm species, and we named it after the locality: Atractolytocestus danjiangkouensis n. sp.
The use of Passeriformes in the eastern Amazonia of Brazil: culture encourages hunting and profit encourages trade
Authors: Silva Samantha , Braga Brenda , Brasil Leandro , Baía-Júnior Pedro , Guimarães Diva 
Published: December 2021

AbstractThis study characterized the ethnoornithological knowledge of passerine bird keepers, known locally ascriadoresorpassarinheiros, who capture, train, breed and sell wild species in the eastern Amazonia of Brazil. The data were collected from 62 bird keepers through informal, semi-structured interviews and participant observation. The family Thraupidae was the most captured group, with 23 species used, predominantly of the genusSporophila.Sporophila angolensishad the highest use value and price. Our findings suggest that conservation strategies should be a priority forSporophila maximiliani,S. angolensesandSaltator maximus. The Passeriformes are obtained by capturing them from the wild, by captive breeding or in trade. They are trapped and sold locally, in nearby municipalities, and also in more distant locations as far as the border with Suriname, French Guiana and Guyana. On the international market, sale prices can reach USD 5,400 per individual bird. Species with both significant economic value and regional cultural significance are of the greatest importance to the bird keepers. To mitigate the negative effects of this activity, we recommend implementation of environmental education programmes for bird keepers, to improve their capacity to raise awareness about wildlife, and to inform them of the legal processes for bird keeping and for breeding birds in captivity for legal trade. Long-term strategies for bird conservation should also be considered, such as the implementation of ecotourism in protected areas to encourage the practice of birdwatching.
Perform hand hygiene and the doors will open – the effectiveness of new system implementation on paediatric intensive care unit visitors’ handwashing compliance
Authors: Shapiro Eli , Mahlab-Guri Keren , Scheier Eric , Ciobotaro Pnina , Guri Alex 
Published: December 2021

Abstract
Hand hygiene (HH) performance on entering intensive care units (ICUs) is commonly accepted but often inadequately performed. We developed a simple, inexpensive module that connects touchless dispensers of alcohol sanitiser (TDAS) to the automatic doors of a paediatric ICU, and assessed the impact of this intervention on HH compliance of hospital staff and visitors. A prospective observational study was conducted over a 3-week period prior to the intervention, followed by a 4-week period post intervention. HH performance was monitored by a research assistant whose office location enabled direct and video-assisted observation of the ICU entrance. A total of 609 entries to the ICU was recorded. Overall HH performance was 46.9% (92/196) before and 98.5% (406/413) after the intervention. Our findings suggest that HH performance on entering an ICU can be improved via a mechanism that makes operation of an automatic door dependent on use of a TDAS system, and thus contribute to infection control.
Pelvic lymph node recurrence in high-risk prostate cancer following prostate-only radiotherapy
Authors: Hussain Sameed , Imran Wajid Muhammad , Omer Muhammad , Yousuf Khan Muhammad , Maqsood Talha , Zeb Adnan 
Published: December 2021

Abstract

Introduction:
High-risk prostate cancer is the most common presentation at our institute among patients with non-metastatic prostate cancer. Traditionally, pelvic lymph nodes were given a prophylactic dose of radiotherapy while the prostate was given a curative dose of radiation. This study aims to evaluate patterns of failure in patients who had prostate-only radiation at our centre.

Materials and Methods:
All high-risk prostate cancer patients who underwent radical radiotherapy to prostate only since 2014 were retrospectively analysed. Local T stage, baseline prostate-specific antigen (PSA) and Gleason score were recorded. Bone scan and staging CT scan data were collected. Various dose levels prescribed to prostate were analysed. The follow-up records of these patients were assessed. Patients who failed in pelvic lymph nodes were recorded separately. Overall survival and failure-free survival were calculated using Kaplan–Meier curve.

Results:
One-hundred five patients fulfilling the inclusion criteria were analysed. Only three patients developed recurrence in pelvic lymph node following prostate-only radiotherapy (PORT). Five year overall survival was 77% while failure-free survival was 64%. Forty patients had a PSA failure after a median follow-up of 62 months.

Conclusions:
Most high-risk prostate cancer patients who progress following hormone therapy and PORT have metastases outside pelvis. Till further conclusive evidence is available PORT can be considered as a safe option.
Data Localization and the National Treatment Obligation in International Investment Treaties
Authors: Zhang Qianwen , Mitchell Andrew 
Published: December 2021

AbstractData localization hurts foreign investment and brings potential economic advantages to domestic corporations relative to foreign corporations. This leads to the argument that data localization violates the national treatment principle in international investment treaties. By applying the ‘three-step’ approach to assess the legality of data localization with respect to the national treatment principle, this article finds that the legality of data localization depends on certain circumstances, including the domestic catalogues of foreign investment, the definition of data localization in domestic legislation, and whether international investment treaties explicitly or implicitly incorporate data protection through exceptions for the protection of the state's essential security interests, public order, or public morals. China's acceleration of its legislation processes to regulate cross-border data transfer has significant implications for the negotiations and modifications of Chinese international investment treaties.
Anthropogenic Aerosols Modulated 20th‐Century Sahel Rainfall Variability Via Their Impacts on North Atlantic Sea Surface Temperature
Authors: Zhang Shipeng , Stier Philip , Dagan Guy , Wang Minghuai 
Published: December 2021

AbstractThe Sahel rainfall has a close teleconnection with North Atlantic sea surface temperature (NASST) variability, which has separately been shown to be affected by aerosols. Therefore, changes in regional aerosols emission could potentially drive multidecadal Sahel rainfall variability. Here we combine ensembles of state‐of‐the‐art global climate models (the CESM and CanESM large ensemble simulations and CMIP6 models) with observational data sets to demonstrate that anthropogenic aerosols have significantly impacted 20th‐century detrended Sahel rainfall multidecadal variability through modifying NASST. We show that aerosol‐induced multidecadal variations of downward solar radiative fluxes over the North Atlantic cause NASST variability during the 20th century, altering the ITCZ position and dynamically linking aerosol effects to Sahel rainfall variability. This process chain is caused by aerosol‐induced changes in radiative surface fluxes rather than changes in ocean circulations. CMIP6 models further suggest that aerosol‐cloud interactions modulate the inter‐model uncertainty of simulated NASST and potentially the Sahel rainfall variability.
Data‐Driven Prediction of Turbulent Flow Statistics Past Bridge Piers in Large‐Scale Rivers Using Convolutional Neural Networks
Authors: Zhang Zexia , Flora Kevin , Kang Seokkoo , Limaye Ajay B. , Khosronejad Ali 
Published: December 2021

AbstractPrediction of statistical properties of the turbulent flow in large‐scale rivers is essential for river flow analysis. The large‐eddy simulation (LES) provides a powerful tool for such predictions; however, it requires a very long sampling time and demands significant computing power to calculate the turbulence statistics of riverine flows. In this study, we developed encoder‐decoder convolutional neural networks (CNNs) to predict the first‐ and second‐order turbulence statistics of the turbulent flow of large‐scale meandering rivers using instantaneous LES results. We train the CNNs using a data set obtained from LES of the flood flow in a large‐scale river with three bridge piers—a training testbed. Subsequently, we employed the trained CNNs to predict the turbulence statistics of the flood flow in two different meandering rivers and bridge pier arrangements—validation testbed rivers. The CNN predictions for the validation testbed river flow were compared with the simulation results of a separately done LES to evaluate the performance of the developed CNNs. We show that the trained CNNs can successfully produce turbulence statistics of the flood flow in the large‐scale rivers, that is, the validation testbeds.
An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity
Authors: Wei Yanping , Tang Xuewu , Ren Yibin , Yang Yun , Song Fengliang , Fu Jingbo , Liu Shuowu , Yu Miao , Chen Jing , Wang Suyang , Zhang Kecheng , Tan Yexiong , Han Zhipeng , Wei Lixin , Zhang Baohua , Cheng Zhangjun , Li Liang , Wang Hongyang 
Published: December 2021

AbstractHepatocellular carcinoma (HCC) is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy. A new modality of epigenetic regulation has emerged involving RNA–RNA crosstalk networks where two or more competing endogenous RNAs (ceRNAs) bind to the same microRNAs. However, the contribution of such mechanisms in HCC has not been well studied. Herein, potential HMGB1-driven RNA–RNA crosstalk networks were evaluated at different HCC stages, identifying the mTORC2 component RICTOR as a potential HMGB1 ceRNA in HBV+ early stage HCC. Indeed, elevated HMGB1 mRNA was found to promote the expression of RICTOR mRNA through competitively binding with the miR-200 family, especially miR-429. Functional assays employing overexpression or interference strategies demonstrated that the HMGB1 and RICTOR 3′untranslated regions (UTR) epigenetically promoted the malignant proliferation, self-renewal, and tumorigenesis in HCC cells. Intriguingly, interference against HMGB1 and RICTOR in HCC cells promoted a stronger anti-PD-L1 immunotherapy response, which appeared to associate with the production of PD-L1+ exosomes. Mechanistically, the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms, activating a positive feedback loop involving mTORC2-AKT-C-MYC to upregulate glutamine synthetase (GS) expression, and inducing mTORC1 signaling to derepress SIRT4 on glutamate dehydrogenase (GDH). Meanwhile, this crosstalk network could impede the efficacy of immunotherapy through mTORC1-P70S6K dependent PD-L1 production and PD-L1+ exosomes activity. In conclusion, our study highlights the non-coding regulatory role of HMGB1 with implications for RNA-based therapeutic targeting together with a prediction of anti-PD-L1 immunotherapy in HCC.
Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database
Authors: McDowell Ronald , Perrott Sarah , Murchie Peter , Cardwell Christopher , Hughes Carmel , Samuel Leslie 
Published: December 2021

AbstractBackgroundAntibiotic-induced gut dysbiosis has been associated with colorectal cancer (CRC) in older adults. This study will investigate whether an association exists between antibiotic usage and early-onset colorectal cancer (CRC), and also evaluate this in later-onset CRC for comparison.MethodsA case-control study was conducted using primary care data from 1999–2011. Analysis were conducted separately in early-onset CRC cases (diagnosed < 50 years) and later-onset cases (diagnosed ≥ 50 years). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (CI) for the associations between antibiotic exposure and CRC by tumour location, adjusting for comorbidities.ResultsSeven thousands nine hundred and three CRC cases (445 aged <50 years) and 30,418 controls were identified. Antibiotic consumption was associated with colon cancer in both age-groups, particularly in the early-onset CRC cohort (<50 years: adjusted Odds Ratio (ORadj) 1.49 (95% CI 1.07, 2.07),p = 0·018; ≥50 years (ORadj(95% CI) 1.09 (1.01, 1.18),p = 0·029). Antibiotics were not associated with rectal cancer (<50 years: ORadj(95% CI) 1.17 (0.75, 1.84),p = 0.493; ≥50 years: ORadj(95% CI) 1.07 (0.96, 1.19),p = 0.238).ConclusionOur findings suggest antibiotics may have a role in colon tumour formation across all age-groups.
Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation
Authors: Ring Nadja Anneliese Ruth , Volpe Maria Concetta , Stepišnik Tomaž , Mamolo Maria Grazia , Panov Panče , Kocev Dragi , Vodret Simone , Fortuna Sara , Calabretti Antonella , Rehman Michael , Colliva Andrea , Marchesan Pietro , Camparini Luca , Marcuzzo Thomas , Bussani Rossana , Scarabellotto Sara , Confalonieri Marco , Pham Tho X. , Ligresti Giovanni , Caporarello Nunzia , Loffredo Francesco S. , Zampieri Daniele , Džeroski Sašo , Zacchigna Serena 
Published: December 2021

SummaryTherapies halting the progression of fibrosis are ineffective and limited. Activated myofibroblasts are emerging as important targets in the progression of fibrotic diseases. Previously, we performed a high-throughput screen on lung fibroblasts and subsequently demonstrated that the inhibition of myofibroblast activation is able to prevent lung fibrosis in bleomycin-treated mice. High-throughput screens are an ideal method of repurposing drugs, yet they contain an intrinsic limitation, which is the size of the library itself. Here, we exploited the data from our “wet” screen and used “dry” machine learning analysis to virtually screen millions of compounds, identifying novel anti-fibrotic hits which target myofibroblast differentiation, many of which were structurally related to dopamine. We synthesized and validated several compounds ex vivo (“wet”) and confirmed that both dopamine and its derivative TS1 are powerful inhibitors of myofibroblast activation. We further used RNAi-mediated knock-down and demonstrated that both molecules act through the dopamine receptor 3 and exert their anti-fibrotic effect by inhibiting the canonical transforming growth factor β pathway. Furthermore, molecular modelling confirmed the capability of TS1 to bind both human and mouse dopamine receptor 3. The anti-fibrotic effect on human cells was confirmed using primary fibroblasts from idiopathic pulmonary fibrosis patients. Finally, TS1 prevented and reversed disease progression in a murine model of lung fibrosis. Both our interdisciplinary approach and our novel compound TS1 are promising tools for understanding and combating lung fibrosis.