bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examination of Retinal and Choroidal Structural Changes in Children With Attention Deficit/Hyperactivity Disorder
Authors: Tosun Zeynep Sena , Ozec Ayse Vural , Erdogan Haydar , Bozali Erman , Yeter Duygu Yalınbas , Cıcek Ayla Uzun , Sarı Seda Aybuke 
Published: April 2021

Abstract
Objective

Examination of retinal nerve, ganglion cell layer thickness and choroidal thickness in patients with Attention Deficit Hyperactivity Disorder by optical coherence tomography (OCT).
Method

: 30 individuals with Attention Deficit Hyperactivity Disorder and 30 healthy individuals compatible in terms of age and gender who applied to the Ophthalmology outpatient clinic for control were included in the study. The right and left eye data of the participants were used in statistical analysis. In addition to full ophthalmological examination (best corrected visual acuity, biomicroscopy, fundus examination), retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and macular choroidal thickness (MCT) were measured by OCT. RNFL, GCL and MCT measurements were compared between the groups.
Conclusion

There was no significant difference between the RNFL and GCL thickness values of the individuals in both groups (p > 0.05). When compared in terms of choroidal thickness, left eye su bfoveal choroidal thickness (p = 0.036, p < 0.05) and 2 mm temporal choroidal thickness were significantly higher in the ADHD group than in the control group (p = 0.034, p < 0.05).
Discussion

The aim of this study was to determine the clinical features of the eyes of children with ADHD. Cross-sectional studies with larger participation are needed to determine RNFL, GCL and choroidal changes.
Steel slag quality control for road construction aggregates and its environmental impact: Case study of Vietnamese steel industry – Leaching of heavy metals from steel making slag
Authors: Nguyen Lan Huong , Nguyen Tien Dung , Tran Thi Viet Nga , Nguyen Duc Luong , Tran Hoai Son , Nguyen Thuy Lien , Nguyen Thi Huong , Nguyen Hoang Giang , Nguyen Tan Phong , Nguyen Ngoc Tuan , Isawa Tomoo , Ta Yasutaka , Sato Ryoichi 
Published: April 2021

Abstract
Steel slag is an industrial by product of steel manufacturing processes and has been widely used in countries like Japan, United States, and European Union nations. However, the current utilization of steel slag in Vietnam is very low mainly because of lack of quality control of slag treatment and chances for reuse of treated steel slag. This paper presents the current steel slag production status and its potential to use as road construction aggregates in consideration of environmental and quality control issues. The basic oxygen furnace (BOF) and electric arc furnace (EAF) slag samples were collected from the seven large steel making factories of Vietnam and brought back to evaluate leaching amount from the slags. The batch leaching test methods were performed at laboratory using the leaching test of steel slag roadbed material in Japan (JIS K 0058 − 1) and Toxicity Characteristic Leaching Procedure (EPA method 1311) widely adopted in Vietnam. The results show that pH level and parameters such as T-Cr, Ni, Cu, Pb, As, Mn differ from the two test methods. The EPA 1311 seems too harsh to evaluate the environmental impacts because in the operation condition of the road, acidic liquid is absent. It is concluded that JIS test, which uses fresh water with gentle mixing not to degradation in size while leaching, is suitable for the evaluation, for the environmental assessment in service of the slag aggregate for roadbed.
Analysis Model of the Value of Information Flow for Decision Making and Performance Improvement in Shop Floor of Developing Countries Using Machine Learning Algorithms
Authors: MBAKOP André Marie , Voufo Joseph , Biyeme Florent , Djomi Rolland , Nanfack Pélagie Flore Temgoua , Meva'a Lucien 
Published: April 2021

Abstract
Performance improvement is a daily activity for Small and Medium Size companies in the manufacturing sector, which always depends on the good management of information flow for a better decision making to facilitate shop floor operations that will have a major impact on quality and timely product delivery to customers. The management of information flow is also conditioned by the characterization of the information flow. In this paper we used the characteristics of information flow to determine and predict an analysis model of the value of information flow that will facilitate decision making in shop floor operations by operators (machine, humans and computers ) through the means of machine learning. The outcome of our work proposes the Decision Trees Model as the better one to predict the value of information flow as long as the characteristics are binary data or scale data, it shows that a digital information can always has a good value of information flow if there is no disruptions and finally we can still have a good value of information flow if using papers, visual, electronic real-time information which are accessible, timely, none volatile, and that has a major concern which the shop floor operations.
Rare chondroblastoma of the 6th left rib, video-assisted thoracoscopy resected: one case report and literature review
Authors: Wu Yonghui , Guan Jiexia , Zhang Kai , Chen Huiguo , Wu Weibin , Zhang Jian 
Published: April 2021

Abstract
Introduction: Chondroblastoma is a rare, benign locally but aggressive bone tumor. It accounts for < 1% of primary bony tumors, and mostly arises from long bones; the rib chondroblastoma is especial rare. Due to its rarity, there are no definitive or standard treatment guidelines. Case presentation: A case of a 24-year-old male with a chondroblastoma located on the 6th posterior left rib. Computed tomography (CT) demonstrated a rib tumor that was a well-defined oval lesion of 20 mm × 18 mm, with lytic bone destruction. The imaging first diagnosis was Langerhans cell histiocytosis (LCH), a giant cell tumor, or other type of neoplasm. The whole tumor and a part of the rib were resected by video-assisted thoracoscopy surgery (VATS). Pathological and immunohistochemical (IHC) examination made a diagnosis of chondroblastoma. Compared with traditional open thoracic surgery, VATS can achieve the same effects and cause less injury to patient. No postoperative adjuvant therapy was given, and had followed 23 months after surgery, there was no recurrence or metastasis.Conclusion: Chondroblastoma has a risk of recurrence and metastasis, surgery plays a role in the treatment of chondroblastoma, and VATS can achieve the same outcome as open thoracic surgery with less pain and lung function. Close follow-up is needed postoperative.
Evaluation of Analgesic and Anti-inflammatory Effects of 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione in Mice
Authors: Athar Junaid , Niazi Zahid Rasul , Niazi Hamid Rasul , Irfan Hafiz Muhammad , Ahmad Taseer , Shah Kiffayat Ullah , Khan kamran Ahmad , Khattak Humayun , yuchi alamgeer , Ali Gowhar , Khan Rasool , Khan Muhammad Javid 
Published: April 2021

Abstract
Purpose: The purpose of the study is to evaluate the analgesic and anti-inflammatory activity of new synthetic compound: 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione and to compare its effects with the available standard drug, diclofenac sodium in mice. Methods: This test compound was evaluated for its anti-nociceptive activity using hot plate and writhing models, while for antiinflammatory activity evaluation, carrageenan and histamine-induced paw edema models were used. Results: In hotplate test, the latency time (in seconds), at 90 minutes of the administered doses (60 and 120 mg/kg) of 5-amino-3- phenyl -1.3.5-thiadiazine-2-thione were 19.5 seconds (p < 0.05) (Mean latency time) and 21.5 seconds (p < 0.01) (Mean latency time) respectively. In writhing test maximum inhibitory effect was demonstrated at a dose of 120 mg/kg with an average of 1.4 (p < 0.001) wriths (this inhibition was more significant) followed by 60 mg/kg (Mean number of wriths = 1.6) (p < 0.001) . The anti-inflammatory effect of the compound for 60 and 120 mg/kg doses was found to be significant and was more significant for 120 mg/kg in both histamine and carrageenan-induced paw edema models. Conclusion: It has been concluded that 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione represents, dose-dependent antinociceptive and anti-inflammatory properties, which are statistically significant. The test compound showed a significant in-vivo peripheral analgesic effect in the writhing test, in comparison to the diclofenac sodium.
Chromosomes Identification based Differential Evolution (CIDE): A New Bio-inspired Variant for Network Intrusion Detection
Authors: Nayer Md. , Pandey Subhash 
Published: April 2021

Abstract
Chromosomes identification is of the paramount importance. The centromeric location of chromosomes is used to classify different species. Plethora of research has already been done in the domain of Bio-inspired computation. However, a Bio-inspired variant of Differential Evolution (DE) is still not designed. In this work attempt has been made for this pursuit and a new variant named as “Chromosomes Identification based Differential Evolution (CIDE)” has been proposed. This technique is used to extract the knowledge from the databases and it constructs effective and reliable decision rules for the purpose of classification. Further, the testing accuracies of proposed CIDE technique has been compared with nearest neighbour classifier (1-NN) optimized by various existing variants of differential evolution and 1-R classifier using six-real datasets, mainly from medical field. The experimental analysis reveals the fact that proposed technique is superior to 1-NN and 1-R classifier. Over and above, Friedman test has also been conducted to validate the superiority of proposed CIDE technique. Moreover, the proposed CIDE algorithm is also tested on KDDCup’99 dataset and different parameters such as classification accuracy, false alarm rate and precision are computed.
Evaluation of the Formability of AA2198-T3 Al-Li alloy in Warm Sheet Hydroforming
Authors: Wang Hui , Cheng Sijia , Ye Zhuang , Wu Tianli , Jin Kai , Guo Xunzhong 
Published: April 2021

Abstract
This study aims to investigate the formability of the AA2198-T3 Al-Li alloy in hydrodynamic deep drawing (HMDD), through experimentation and finite element simulation. The effects of the most critical factors were studied: die cavity pressure and forming temperature. The Gurson−Tvergaard−Needleman model (GTN model) was employed to analyze the formability of AA2198-T3 Al-Li alloy and predict the fracture in the hydroforming of a cylindrical part. Both the numerical and experimental results showed that the increase of the pressure inside the liquid chamber, within a certain range, contributes to improve the formability of the alloy. Increasing the temperature would reduce the required pressure for sheet hydroforming. Notably, the appropriate chamber pressure was beneficial to form good quality parts with a relatively uniform wall thickness. By analyzing the fracture morphologies, the brittle fracture of AA2198-T3 plays a main role at room temperature, but the ductile fracture was shown at the elevated temperature.
Analysis on Damaging Mechanism of Sand-Mud Interbedded Strata Type Perilous Rock
Authors: Dong Ping , Zhou Yuntao , Liang Dan 
Published: April 2021

Abstract
Aiming at the sand-mud interbedded strata type perilous rock, this paper comprehensively analyzes the reason of formation of perilous rock and its structural characteristics, builds the physical and mechanical mode of the sand-mud interbedded strata type perilous rock, puts forward the base retreat mechanism that the mudstone’s softening, compression and deformation induce the tension damage of thin layer sandstone, explains slip-shear damage mode and dump-fall damage mode of perilous rock, and proposes mechanical criteria of two damage modes. According to the results of case analysis, the base retreat of perilous rock in Leijiagou conforms to the mechanical mechanisms of the tension and damage of thin layer sandstone induced by the softening, compression and deformation. Under current situations, there will be no slip-shear damage or dump-fall damage for the Leijiagou Perilous Rock. According to preliminary projections, the Leijiagou Perilous Rock will lose its stability after 15.2 years, with the damage mode being dump-fall damage and the critical depth of cavity being 4.1m.
Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization
Authors: Brown Anna-Leigh , Wilkins Oscar , Keuss Matthew , Hill Sarah , Zanovello Matteo , Lee Weaverly , Lee Flora , Masino Laura , Qi Yue , Byrce-Smith Sam , Bampton Alexander , Gatt Ariana , Phatnani Hemali , Schiavo Giampietro , Fisher Elizabeth , Raj Towfique , Secrier Maria , Lashley Tammaryn , Ule Jernej , Buratti Emanuele , Humphrey Jack , Ward Michael , Fratta Pietro 
Published: April 2021

Abstract
Variants within the UNC13A gene have long been known to increase risk of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative diseases defined by mislocalization of the RNA-binding protein TDP-43. Here, we show that TDP-43 depletion induces robust inclusion of a cryptic exon (CE) within UNC13A, a critical synaptic gene, resulting in nonsense-mediated decay and protein loss. Strikingly, two common polymorphisms strongly associated with ALS/FTD risk directly alter TDP-43 binding within the CE or downstream intron, increasing CE inclusion in cultured cells and in patient brains. Our findings, which are the first to demonstrate a genetic link specifically between loss of TDP-43 nuclear function and disease, reveal both the mechanism by which UNC13A variants exacerbate the effects of decreased nuclear TDP-43 function, and provide a promising therapeutic target for TDP-43 proteinopathies.
Genetic diversity of Dengue virus serotypes circulating among Aedes mosquitoes in selected regions of Nigeria
Authors: Isa Ibrahim , Ndams Iliya Shehu , Aminu Maryam , Chechet Gloria , Dotzauer Andreas , Simon Ayo Yila 
Published: April 2021

Abstract
The DENV mosquito vector is endemic to tropical and subtropical climates, placing ∼40% of the world’s population at direct risk of dengue infection. Currently, in Nigeria the status of DENV serotypes circulating among mosquitoes’ vectors is unknown. Our study was designed to identify and characterize the DENV serotypes circulating in Aedes mosquito populations collected in selected sites in Nigeria. The mosquitoes were collected, identified morphologically to species level using colored identification keys of Rueda. Generally, each species identified was tested in pools of 20 individuals of each Aedes species. RT-PCR and nested PCR were used to detected DENV serotypes in mosquitoes and characterized using Sanger sequencing methods. The results show that DENV serotypes were detected in 58.54% of the pools of mosquitoes screened. This corroborates with our unpublished report on the presence of DENV IgM antibodies in humans in the same study area. All DENV1-4 serotypes were detected in Ae. aegypti, Ae. albopictus and Ae. gaillosi with DENV4 serotype being reported for the first time in Nigeria. DENV2 (37.8%) was the most detected serotypes, while double and triple co-infections of serotypes were detected in 24.4% of the pools. Phylogenetic analysis revealed a strong evolutionary relatedness of DENV serotypes in our study with that of South and Southeast Asia, North America, and other African countries. This is the first reports on the co-infection of natural DENV in Aedes species pools in Nigeria. Thus, our study speculates a possible linkage between DENV serotypes and febrile flu-like disease burden being experienced by host communities in northern Nigeria.
Impedance Characterization of AlGaN/GaN/Si High Electron Mobility Transistors
Authors: MOSBAHI Hana , GASSOUMI Malek , ZAIDI MOhamed Ali 
Published: April 2021

Abstract
AlGaN/GaN HEMTs grown on high resistive silicon (111) substrate grown by molecular beam epitaxy have been investigated using impedance measurements. Passivation of the HEMT devices is made in order to improve the electron transport. As has been found from conductance data, the electron traps are eliminated after passivation. The impedance spectroscopy has been, on the other hand, studied from the electrical transport. As a result, a complex impedance plot was revealed an equivalent circuit models indicating single semicircles and the solid interface.
Experimental Study on the Acoustic Emission Characteristics of Saturated Sandstone Fractures with Different Orientations
Authors: Li Gangwei , Cheng Yunhai , Wang Yifan , Li Fenghui , Wang Xiangqian , Xiong Tenggen 
Published: April 2021

Abstract
In order to investigate the mechanical characteristics of rocks under saturated water conditions, uniaxial loading experiments were conducted on rock specimens using the RMT-150B Rock Mechanics Experiment System based on theoretical analysis of the damage evolution mechanism of rock specimens considering saturation factors. And the damage of the specimens was monitored using the Soft Island DS5-16B acoustic emission system. During the test, the specimens were taken from six rock samples in different directions at the same roadway section location in a coal mine. The combined findings suggest that: The dispersion rate is positively correlated with the bearing capacity of rock specimens taken from different directions, AE ringing counts, amplitude, and energy appear to have a time-limited steady increase influenced by direction. For rock specimens in the same plane, the rock damage instantaneous energy lag amplitude and AE activity is proportional to the direction angle. The AE localization points in different directions are randomly distributed and scattered in various areas, and fracture beams and surface cracks are produced inside the rock corresponding to the AE acoustic emission.
The Effect of High Temperatures on Risk of Hospitalization in Northern Vietnam
Authors: Talukder Mohammad Radwanur , Chu Cordia , Rutherford Shannon , Huang Cunrui , Phung Dung 
Published: April 2021

Abstract
The evidence on the temperature and morbidity relationship is limited, especially from tropical regions including Vietnam. This study’s objective was to examine the high temperature-hospitalisation relationship in northern Vietnam. To assess ambient temperature hospitalizations associations in seven provinces of northern Vietnam Generalized Linear and Distributed Lag Models were used. Overall risk for all causes, and infectious, cardiovascular, and respiratory admissions in study provinces was estimated using a random-effects meta-analysis. The pooled estimates showed a significant effect of high temperature on same day (Lag 0) hospitalizations. A 1°C increase in temperature was significantly associated with 1.1% (95% Confidence Interval- CI, 0.9–1.4%) increase in risk for all-cause, 2.4% (95% CI, 1.9–2.9%) increase in risk for infectious, 1.3% (95% CI, 0.9–1.6%) increase in risk for respiratory, and 0.5% (95% CI, 0.1–0.9%) increase in risk for cardiovascular disease admissions. However, the province specific temperature-hospitalisation effect was variable and mostly inconsistent for cardiovascular diseases. Our research in northern Vietnam adds to the evidence of high temperatures associated with hospitalisations in a sub-tropical climate. Our findings have important implications for promoting appropriate adaptation strategies to reduce climate change associated health impacts in similar settings.
Predicting Hosts Based on Early SARS-CoV-2 Samples and Analyzing Later World-wide Pandemic in 2020
Authors: Guo Qian , Li Mo , Wang Chunhui , Guo Jinyuan , jiang xiaoqing , Tan Jie , Wu Shufang , Wang Peihong , Xiao Tingting , Zhou Man , Fang Zhencheng , Xiao Yonghong , Zhu Huaiqiu 
Published: April 2021

Abstract
The SARS-CoV-2 pandemic has raised the concern for identifying hosts of the virus since the early-stage outbreak. To address this problem, we proposed a deep learning method, DeepHoF, based on extracting the viral genomic features automatically, to predict host likelihood scores on five host types, including plant, germ, invertebrate, non-human vertebrate and human, for novel viruses. DeepHoF made up for the lack of an accurate tool applicable to any novel virus and overcame the limitation of the sequence similarity-based methods, reaching a satisfactory AUC of 0.987 on the five-classification. Additionally, to fill the gap in the efficient inference of host species for SARS-CoV-2 using existed tools, we conducted a deep analysis on the host likelihood profile calculated by DeepHoF. Using the isolates sequenced in the earliest stage of COVID-19, we inferred minks, bats, dogs and cats were potential hosts of SARS-CoV-2, while minks might be one of the most noteworthy hosts. Several genes of SARS-CoV-2 demonstrated their significance in determining the host range. Furthermore, the large-scale genome analysis, based on DeepHoF’s computation for the later world-wide pandemic in 2020, disclosed the uniformity of host range among SARS-CoV-2 samples and the strong association of SARS-CoV-2 between humans and minks.
Accuracy of Institutional Orthopaedic Trauma Databases: A Retrospective Chart Review
Authors: Chopra Aman , Cortez Abigail , Naga Ashraf El , Ding Anthony , Morshed Saam 
Published: April 2021

Abstract
Introduction: Academic trauma institutions rely on fracture databases as research and quality control tools. Frequently, these databases are populated by trainees, but the completeness and accuracy of such databases has not yet been evaluated. The purpose of this study is to determine the capture rate of a resident-populated database in collecting extremity fractures and to determine the accuracy of assigned Orthopaedic Trauma Association (OTA) classifications.Materials and Methods: A retrospective study was performed at a level one trauma center of all adult patients who underwent treatment for extremity fractures after an emergency department or inpatient consultation. A 20% random sample was taken from these entries and compared to a resident-populated fracture database designed to capture the same patients. For all matching records containing a resident-assigned OTA classification, relevant imaging was blindly reviewed by a trauma fellowship-trained orthopaedic attending surgeon for fracture pattern classification. Resident OTA classifications were compared to this gold standard to determine overall accuracy rate.Results: 318 (80%) out of 400 entries were captured by the resident-populated database. 231 of these 318 entries contained an OTA classification. 153 (66%) of these 231 entries demonstrated concordance between resident and attending assigned OTA classifications. On subgroup analysis, 133 (70%) of the 190 lower extremity classifications were accurately identified as compared to just 20 (49%) of the 41 upper extremity classifications (p = 0.009). 79 (65%) of the 121 end segment fractures showed agreement versus 42 (67%) of the 63 diaphyseal injury patterns (p = 0.85). Accuracy of classification did not significantly vary by resident year of training (p = 0.142). Conclusion: Trainee generated databases at academic institutions may be subject to incomplete data entry and inaccurate fracture classifications. Quality control measures should be instituted to ensure accuracy in such databases if efforts are invested with the expectation of useful information.