bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Land Surface Dry/Wet Conditions Mining Based on Spatial‐Temporal Association Rules
Authors: Zheng Kun , Qin Wei , Du Xiaoping 
Published: July 2021

AbstractSevere drought and wetness would have serious impacts on human society and natural environment. Discovering the implicit relationships among severely dry/wet conditions is of great significance for meteorological disaster early warning and risk management strategy formulation. In this study, we propose an improved spatial‐temporal association rule mining algorithm to mine the global dry/wet associations. A modified time‐lagged association rule mining algorithm is first developed to mine unit‐to‐unit dry/wet association rules. Then, a density‐based clustering algorithm is employed to identify associated dry/wet zones. The gridded Standardized Precipitation Evapotranspiration Index (SPEI) data sets at 12‐ and 3‐month time scales were used to characterize annual and seasonal dry/wet conditions. Analysis results show that there are strong dry/wet associations between many regions. Some of the discovered association rules reflect similar associations with known phenomena, indicating the effectiveness and feasibility of the method. Other rules were previously unknown and can provide new knowledge for this research field. Several predictions can be made according to the discovered rules that western Oman and southeastern Saudi Arabia would suffer severe or extreme drought in 2021 and northwestern China would suffer severe or extreme drought in 2025 with probabilities exceeding 77%; northwestern China, northern Argentina, and western Australia would experience severe or extreme wetness in 2021, 2022, and 2023, respectively, with probabilities exceeding 85%. The algorithm provides a new perspective for analyzing dry/wet associations and the discovered associations can be used as theoretical bases for local governments to take precautions to mitigate the potential impacts of severe drought or wetness.
Biogeochemical Gradients in a Serpentinization‐Influenced Aquifer: Implications for Gas Exchange Between the Subsurface and Atmosphere
Authors: Sabuda Mary C. , Putman Lindsay I. , Hoehler Tori M. , Kubo Michael D. , Brazelton William J. , Cardace Dawn , Schrenk Matthew O. 
Published: July 2021

AbstractSerpentinization involves the hydration and alteration of ultramafic rocks, which produces hydrogen (H2) and methane (CH4) and results in distinctive groundwater chemistries. As reacted fluids mix with recharging surface water, gradients in chemistry and microbiology develop in the subsurface. We present a comprehensive analysis of biogeochemical gradients in the water column of a serpentinite‐hosted well, CSW1.1, at the Coast Range Ophiolite Microbial Observatory (CROMO) in California, USA. Samples for geochemistry, 16S rRNA gene sequencing, and metagenomics were collected at four discrete depths from the top of the well corresponding to 100%, 50%, 15%, and 0% of atmospheric oxygen (O2) levels, and from the well base at 19.5 m depth. Gibbs energy calculations assessed the energy available for a suite of reactions coupled to O2, sulfate (SO42−), and nitrate (NO3−). Metagenomic data from the profile was used to construct metagenome assembled genomes (MAGs) to evaluate the completeness of biochemical pathways and compare the relative abundance of key diagnostic genes. Bioenergetic data point to the favorability of CH4 oxidation reactions despite little genetic evidence for this. Amplicon sequencing results highlight the abundance of key taxa affiliated with the genera Truepera, Serpentinomonas, and Dethiobacter. Although concentrations of NO3− and H2 are low, genes for NO3− reduction and oxidation of H2 and carbon monoxide (CO) were found in high abundance. Conceptual modeling results demonstrate the net depletion of H2 and CO in the groundwater, the consumption of CO2 and O2, and the potential for CH4 emission into the atmosphere at this terrestrial site of serpentinization.
Nutrient Budgets Calculated in Floodwaters Using a Whole‐Ecosystem Reservoir Creation and Flooding Experiment
Authors: Talbot Ceara J. , Paterson Michael J. , Beaty Kenneth G. , Bodaly Richard A. (Drew) , Xenopoulos Marguerite A. 
Published: July 2021

AbstractFlooding in forested areas can release nutrients via organic matter flushing and organic matter decomposition and contribute to nutrient loading in aquatic ecosystems. Organic matter content may set an upper limit for nutrient release during flooding, but variation in timing, depth, duration of inundation, and site organic matter substrate inhibit comparison across sites and events. We used data collected during a whole‐ecosystem flooding experiment conducted at the IISD‐Experimental Lakes Area (ELA) in northwestern Ontario to examine the relationship between site organic matter content and nutrient release on both a short‐term (first 3 weeks) and annual scale (open‐water season). Three upland forest sites with differing amounts of organic matter stored in soil and vegetation were flooded to create experimental reservoirs. We hypothesized that the magnitude of nutrient release would be related to the organic matter content in each site. We found that nutrient concentrations increased relative to low‐nutrient water pumped into each reservoir at both scales, but there was no relationship between site organic matter content and short‐term total nitrogen (TN) and total phosphorus (TP) concentrations or annual TN and TP fluxes. Additionally, N and P release rates differed, decreasing TN:TP ratios in reservoirs and outflows relative to inflows. Nutrient concentrations increased immediately after inundation each year and continued for 5 years of repeated flooding. Predicted increases in flooding due to changing precipitation patterns and reservoir creation may cause forested areas to be a long‐term nutrient source to aquatic ecosystems. Over time, nutrient accumulation may affect water quality, shift biological communities, and influence ecosystem functioning.
Influence of Invasive Submerged Aquatic Vegetation (E. densa) on Currents and Sediment Transport in a Freshwater Tidal System
Authors: Lacy Jessica R. , Foster‐Martinez Madeline R. , Allen Rachel M. , Drexler Judith Z. 
Published: July 2021

AbstractWe present a field study combining measurements of vegetation density, vegetative drag, and reduction of suspended‐sediment concentration (SSC) within patches of the invasive submerged aquatic plant Egeria densa. Our study was motivated by concern that sediment trapping by E. densa, which has proliferated in the Sacramento–San Joaquin Delta, is impacting marsh accretion and reducing turbidity. In the freshwater tidal Delta, E. densa occupies shallow regions frequently along channel margins. We investigated two sites: Lindsey Slough, a muddy low‐energy backwater, and the lower Mokelumne River, with stronger currents and sandy bed sediments. At the two sites, biomass density, frontal area, and areal density of the submerged aquatic vegetation (SAV) were similar. Current attenuation within E. densa exceeded 90% and the vegetative drag coefficient followed , where is stem Reynolds number. The SAV reduced SSC by an average of 18% in Lindsey Slough. At the Mokelumne River the reduction ranged 0%–40%, with greatest trapping when discharge and SSC were elevated. This depletion of SSC decreases the transport of sediment to marshes by the same percentage, as the rising tide must pass through fringing SAV before reaching marshes. Sediment trapping in E. densa in the Delta is limited by low flux through the canopy and low settling velocity of suspended sediment (mostly flocculated mud). Sediment trapping by SAV has the potential to reduce channel SSC, but the magnitude and sign of the effect can vary with local factors including vegetative coverage and the depositional or erosional nature of the setting.
Variations in the Near‐Infrared Spectral Properties of Ferrous Mineral Mixtures With Different Relative Abundances
Authors: Zhang Xunyu , Cloutis Edward 
Published: July 2021

AbstractIn near‐infrared spectral studies, the relationship between the 1‐μm absorption (Band I) center and the band area ratio (BAR, the area ratio of 2–1‐μm absorption features) is useful in compositional and mineralogical analyses of ferrous mineral‐bearing mixtures. Zhang and Cloutis (2020), https://doi.org/10.1029/2020ea001153, investigated various lunar ferrous iron‐bearing rocks and minerals and found that pyroxene‐bearing materials rich in ilmenite (Ilm), plagioclase (Pl), or glass are offset from the lunar olivine‐clinopyroxene‐orthopyroxene (Ol‐Cpx‐Opx) mixing line in the plot of the BAR versus the Band I center. To analyze the variation trends of the spectral properties of these mixtures with different components, this study presents a systematic evaluation of laboratory spectra of terrestrial and synthetic ferrous iron‐bearing mineral mixtures based on published databases. In general, the mixing trends of the Pl‐pyroxene mixtures, the glass‐pyroxene mixtures, and the Ilm‐basalt mixtures are consistent with the findings of Zhang and Cloutis (2020), https://doi.org/10.1029/2020ea001153. Moreover, this study also finds that the BAR of the Pl‐pyroxene mixtures varies nonlinearly with different relative abundances and that the BAR is generally not sensitive to Pl abundances below 60%. For glass‐pyroxene mixtures, the corresponding data points are usually appreciably offset from the Ol‐Cpx‐Opx mixing line at glass abundances above 20%. The BAR of the Ilm‐basalt mixtures increases with increasing Ilm content, mainly due to the weakening of 1‐μm absorption generally being greater than that of 2‐μm absorption.
Stable ≠ Sustainable: Delta Dynamics Versus the Human Need for Stability
Authors: Passalacqua P. , Giosan L. , Goodbred S. , Overeem I. 
Published: July 2021

AbstractArising from the non‐uniform dispersal of sediment and water that build deltaic landscapes, morphological change is a fundamental characteristic of river delta behavior. Thus, sustainable deltas require mobility of their channel networks and attendant shifts in landforms. Both behaviors can be misrepresented as degradation, particularly in context of the “stability” that is generally necessitated by human infrastructure and economies. Taking the Ganges‐Brahmaputra‐Meghna Delta as an example, contrary to public perception, this delta system appears to be sustainable at a system scale with high sediment delivery and long‐term net gain in land area. However, many areas of the delta exhibit local dynamics and instability at the scale at which households and communities experience environmental change. Such local landscape “instability” is often cited as evidence that the delta is in decline, whereas much of this change simply reflects the morphodynamics typical of an energetic fluvial‐delta system and do not provide an accurate reflection of overall system health. Here we argue that this disparity between unit‐scale sustainability and local morphodynamic change may be typical of deltaic systems with well‐developed distributary networks and strong spatial gradients in sediment supply and transport energy. Such non‐uniformity and the important connections between network sub‐units (i.e., fluvial, tidal, shelf) suggest that delta risk assessments must integrate local dynamics and sub‐unit connections with unit‐scale behaviors. Structure and dynamics of an integrated deltaic network control the dispersal of water, solids, and solutes to the delta sub‐environment and thus the local to unit‐scale sustainability of the system over time.
Investigating Atmospheric Inputs of Dissolved Black Carbon to the Santa Barbara Channel During the Thomas Fire (California, USA)
Authors: Wagner Sasha , Harvey Elizabeth , Baetge Nicholas , McNair Heather , Arrington Eleanor , Stubbins Aron 
Published: July 2021

AbstractThe Thomas Fire ignited on December 4, 2017 and burned for over one month. As the Thomas Fire burned, Santa Ana winds carried a thick plume of smoke and ash over the Santa Barbara Channel. We sought to determine whether the deposition of Thomas Fire ash to the Santa Barbara Channel had a measurable effect on the concentration and stable carbon isotopic composition (δ13C) of dissolved black carbon (DBC) in coastal waters. DBC is the condensed aromatic fraction of thermally altered organic carbon quantified using the benzenepolycarboxylic acid (BPCA) method. DBC δ13C signatures were determined via BPCA‐specific stable carbon isotopic analysis. Surface water DBC concentrations beneath the smoke plume were up to 13% higher than other sampling stations. Via controlled leaching experiments, we found that Thomas Fire ash released a considerable amount of DBC in seawater (1.4 g‐DBC per kg of ash organic carbon), which was further enhanced by photodissolution. By combining in situ and experimental data, we constructed an isotopic mixing model to estimate inputs of ash‐derived DBC to marine surface waters. Although we were able to detect slight elevations in DBC concentrations beneath the smoke plume, the ash‐derived contributions were too small to meaningfully shift the δ13C signature, which resulted in an observed mismatch between modeled and measured DBC δ13C values. Few studies have investigated the immediate impacts of wildfire on coastal biogeochemistry. Therefore, our work provides an important foundation for understanding atmospheric contributions of fire‐derived DBC to coastal margins.
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome
Authors: Lleó Alberto , Zetterberg Henrik , Pegueroles Jordi , Karikari Thomas K. , Carmona-Iragui María , Ashton Nicholas J. , Montal Victor , Barroeta Isabel , Lantero-Rodríguez Juan , Videla Laura , Altuna Miren , Benejam Bessy , Fernandez Susana , Valldeneu Silvia , Garzón Diana , Bejanin Alexandre , Iulita Maria Florencia , Camacho Valle , Medrano-Martorell Santiago , Belbin Olivia , Clarimon Jordi , Lehmann Sylvain , Alcolea Daniel , Blesa Rafael , Blennow Kaj , Fortea Juan 
Published: July 2021

AbstractPlasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic, 43 prodromal AD, 83 AD dementia) and 44 euploid cognitively normal controls. We measured plasma p-tau181 with a Single molecule array (Simoa) assay. We examined the diagnostic performance of p-tau181 for the detection of AD and the relationship with other fluid and imaging biomarkers. Plasma p-tau181 concentration showed an area under the curve of 0.80 [95% CI 0.73–0.87] and 0.92 [95% CI 0.89–0.95] for the discrimination between asymptomatic individuals versus those in the prodromal and dementia groups, respectively. Plasma p-tau181 correlated with atrophy and hypometabolism in temporoparietal regions. Our findings indicate that plasma p-tau181 concentration can be useful to detect AD in DS.
A multi-responsive healable supercapacitor
Authors: Qin Haili , Liu Ping , Chen Chuanrui , Cong Huai-Ping , Yu Shu-Hong 
Published: July 2021

AbstractSelf-healability is essential for supercapacitors to improve their reliability and lifespan when powering the electronics. However, the lack of a universal healing mechanism leads to low capacitive performance and unsatisfactory intelligence. Here, we demonstrate a multi-responsive healable supercapacitor with integrated configuration assembled from magnetic Fe3O4@Au/polyacrylamide (MFP) hydrogel-based electrodes and electrolyte and Ag nanowire films as current collectors. Beside a high mechanical strength, MFP hydrogel exhibits fast optical and magnetic healing properties arising from distinct photothermal and magneto-thermal triggered interfacial reconstructions. By growing electroactive polypyrrole nanoparticles into MFP framework as electrodes, the assembled supercapacitor exhibits triply-responsive healing performance under optical, electrical and magnetic stimuli. Notably, the device delivers a highest areal capacitance of 1264 mF cm−2 among the reported healable supercapacitors and restores ~ 90% of initial capacitances over ten healing cycles. These prominent performance advantages along with the facile device-assembly method make this emerging supercapacitor highly potential in the next-generation electronics.
Extensive standing genetic variation from a small number of founders enables rapid adaptation in Daphnia
Authors: Chaturvedi Anurag , Zhou Jiarui , Raeymaekers Joost A. M. , Czypionka Till , Orsini Luisa , Jackson Craig E. , Spanier Katina I. , Shaw Joseph R. , Colbourne John K. , De Meester Luc 
Published: July 2021

AbstractWe lack a thorough understanding of the origin and maintenance of standing genetic variation that enables rapid evolutionary responses of natural populations. Whole genome sequencing of a resurrected Daphnia population shows that standing genetic variation in over 500 genes follows an evolutionary trajectory that parallels the pronounced and rapid adaptive evolution of multiple traits in response to predator-driven natural selection and its subsequent relaxation. Genetic variation carried by only five founding individuals from the regional genotype pool is shown to suffice at enabling the observed evolution. Our results provide insight on how natural populations can acquire the genomic variation, through colonization by a few regional genotypes, that fuels rapid evolution in response to strong selection pressures. While these evolutionary responses in our study population involved hundreds of genes, we observed no evidence of genetic erosion.
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization
Authors: Zhang Lijuan , Zhang Kai , Zhang Jieyou , Zhu Jinrong , Xi Qing , Wang Huafeng , Zhang Zimu , Cheng Yingnan , Yang Guangze , Liu Hongkun , Guo Xiangdong , Zhou Dongmei , Xue Zhenyi , Li Yan , Zhang Qi , Da Yurong , Liu Li , Yin Zhinan , Yao Zhi , Zhang Rongxin 
Published: July 2021

AbstractCommon fragile sites (CFSs) are specific breakage-prone genomic regions and are present frequently in cancer cells. The (E2-independent) E3 ubiquitin-conjugating enzyme FATS (fragile site-associated tumor suppressor) has antitumor activity in cancer cells, but the function of FATS in immune cells is unknown. Here, we report a function of FATS in tumor development via regulation of tumor immunity. Fats−/− mice show reduced subcutaneous B16 melanoma and H7 pancreatic tumor growth compared with WT controls. The reduced tumor growth in Fats−/− mice is macrophage dependent and is associated with a phenotypic shift of macrophages within the tumor from tumor-promoting M2-like to antitumor M1-like macrophages. In addition, FATS deficiency promotes M1 polarization by stimulating and prolonging NF-κB activation by disrupting NF-κB/IκBα negative feedback loops and indirectly enhances both CD4+ T helper type 1 (Th1) and cytotoxic T lymphocyte (CTL) adaptive immune responses to promote tumor regression. Notably, transfer of Fats−/− macrophages protects mice against B16 melanoma. Together, these data suggest that FATS functions as an immune regulator and is a potential target in cancer immunotherapy.
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
Authors: Romero Octavio A. , Vilarrubi Andrea , Alburquerque-Bejar Juan J. , Gomez Antonio , Andrades Alvaro , Trastulli Deborah , Pros Eva , Setien Fernando , Verdura Sara , Farré Lourdes , Martín-Tejera Juan F. , Llabata Paula , Oaknin Ana , Saigi Maria , Piulats Josep M. , Matias-Guiu Xavier , Medina Pedro P. , Vidal August , Villanueva Alberto , Sanchez-Cespedes Montse 
Published: July 2021

AbstractDespite the genetic inactivation of SMARCA4, a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient tumours. Here, we show that, unlike the cells with activated MYC oncogene, cells with SMARCA4 inactivation are refractory to the histone deacetylase inhibitor, SAHA, leading to the aberrant accumulation of H3K27me3. SMARCA4-mutant cells also show an impaired transactivation and significantly reduced levels of the histone demethylases KDM6A/UTX and KDM6B/JMJD3, and a strong dependency on these histone demethylases, so that its inhibition compromises cell viability. Administering the KDM6 inhibitor GSK-J4 to mice orthotopically implanted with SMARCA4-mutant lung cancer cells or primary small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT), had strong anti-tumour effects. In this work we highlight the vulnerability of KDM6 inhibitors as a characteristic that could be exploited for treating SMARCA4-mutant cancer patients.
Two end-member earthquake preparations illuminated by foreshock activity on a meter-scale laboratory fault
Authors: Yamashita Futoshi , Fukuyama Eiichi , Xu Shiqing , Kawakata Hironori , Mizoguchi Kazuo , Takizawa Shigeru 
Published: July 2021

AbstractThe preparation process of natural earthquakes is still difficult to quantify and remains a subject of debate even with modern observational techniques. Here, we show that foreshock activity can shed light on understanding the earthquake preparation process based on results of meter-scale rock friction experiments. Experiments were conducted under two different fault surface conditions before each run: less heterogeneous fault without pre-existing gouge and more heterogeneous fault with pre-existing gouge. The results show that fewer foreshocks occurred along the less heterogeneous fault and were driven by preslip; in contrast, more foreshocks with a lower b value occurred along the more heterogeneous fault and showed features of cascade-up. We suggest that the fault surface condition and the stress redistribution caused by the ongoing fault slip mode control the earthquake preparation process, including the behavior of foreshock activity. Our findings imply that foreshock activity can be a key indicator for probing the fault conditions at present and in the future, and therefore useful for assessing earthquake hazard.
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination
Authors: Barros-Martins Joana , Hammerschmidt Swantje I. , Cossmann Anne , Odak Ivan , Stankov Metodi V. , Morillas Ramos Gema , Dopfer-Jablonka Alexandra , Heidemann Annika , Ritter Christiane , Friedrichsen Michaela , Schultze-Florey Christian , Ravens Inga , Willenzon Stefanie , Bubke Anja , Ristenpart Jasmin , Janssen Anika , Ssebyatika George , Bernhardt Günter , Münch Jan , Hoffmann Markus , Pöhlmann Stefan , Krey Thomas , Bošnjak Berislav , Förster Reinhold , Behrens Georg M. N. 
Published: July 2021

AbstractCurrently approved viral vector-based and mRNA-based vaccine approaches against coronavirus disease 2019 (COVID-19) consider only homologous prime-boost vaccination. After reports of thromboembolic events, several European governments recommended using AstraZeneca’s ChAdOx1-nCov-19 (ChAd) only in individuals older than 60 years, leaving millions of already ChAd-primed individuals with the decision to receive either a second shot of ChAd or a heterologous boost with mRNA-based vaccines. However, such combinations have not been tested so far. We used Hannover Medical School’s COVID-19 Contact Study cohort of healthcare professionals to monitor ChAd-primed immune responses before and 3 weeks after booster with ChAd (n = 32) or BioNTech/Pfizer’s BNT162b2 (n = 55). Although both vaccines boosted prime-induced immunity, BNT162b2 induced significantly higher frequencies of spike-specific CD4+ and CD8+ T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and P.1 variants of concern of severe acute respiratory syndrome coronavirus 2.