bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017
Authors: SAHİN Orhan , GÖKALP Gamze , HOCAOGLU Nil , YILDIZTEPE Engin , KALKAN Şule 
Published: May 2021

Purpose: The purpose of our study is to reveal the demographic features, exposure routes and reasons for exposure, clinical effects and outcomes of cardiovascular drug poisonings reported to the Dokuz Eylul University Drug and Poison Information Center (DEUDPIC) between January 2014 and December 2017.
Methods: This retrospective, descriptive, and cross-sectional study was approved by the Noninvasive Research Ethics Committee of Dokuz Eylül University School of Medicine. All data were recorded on standard data forms and then transferred to a software (Ruber, written by Engin Yildiztepe, 2007) for data analysis.
Results: There were 43 poisonings cases were reported with cardiovascular drugs. Female cases were common (60.47%). Half of the poisoning cases were toxic (51.16%). The most common reason of poisonings was intentional (81.40%). All of cases between 13-49 age group were intentional exposures. Only single substance intakes were responsible for the most of the drug exposures (62.79%). The most common agents were beta-blockers (29.85%), medicines that affect the renin-angiotensin system (23.88 %), calcium channel blockers (11.94%) and cardiac therapy drugs such as digoxin (11.94%). Clinical signs and symptoms were classified as asymptomatic (37.21%), mild (23.26%), moderate (23.26%), and severe (4.65%). Recommended treatments were observation and supportive care (46.67%), decontamination methods (44.00%) and antidote therapy (2.67%). One fatality was reported.
Conclusions: We suggest that determination of the epidemiological characteristics of cardiovascular drug exposures in our country through prospectively multi-centered studies may provide significant contributions to prevent poisonings and decrease the mortality and morbidity of the cases.
EMERGENCY MANAGEMENT OF THE PRE-HOSPITAL PHASE IN COVID 19 PATIENT: LITERATURE REVIEW
Authors: Mohtar M Sobirin , Rahma Mahmuddin 
Published: May 2021

The addition of Covid-19 cases took place quite quickly and has spread between countries. The high incidence is important to improve health services, especially the pre-hospital phase services. In this phase, good emergency management will reduce the number of disability to death by up to 50% by starting from activating calls prior to the incident location, health workers who understand first aid and transportation using an ambulance and being observed until they arrive at the hospital. Knowing the Pre-Hospital Phase Emergency Management in Covid-19 Patient: Literature Review.Â The research method used is a literature review. In this method, online searches for articles, journals and books are carried out using accessible databases, namely Google Scholar, PubMed,Â and Biomed Central. It is known from 10 Literature Articles, journals and books in the emergency management of Covid-19 in the Pre-Hospital phase must be done as much as possible to minimize the number of deaths and transmission that occurs. Handling of emergency Covid-19 in the Pre-Hospital phase includes: Basic and Advanced Life Support (BLS), Oxygen Therapy, Personal Protective Equipment (PPE),Â and Patient Transport. It is important for medical personnel to pay attention to many things in providing emergency nursing care to Covid-19 patient.Â Pre-Hospital emergency measures for patient with Covid-19 can be carried out in various ways to improve the patient condition while at the Pre-Hospital, besides that, it can also prevent transmission to medical personnel and people around Covid-19 patient.
IDENTIFICATION OF CYCLAMATE ON BRANDED AND UNBRANDED BUBLE DRINK IN DENPASAR CITY
Authors: Laksmita W Ayu Saka , Widayanti Ni Putu , Risky VA Desak Putu 
Published: May 2021

Bubble drink is a drink that is on the rise at this time. This drink is liked by many people Bubble drink is a drink that is on the rise at this time.Â This drink is liked by many people because it has a sweet taste.Â To create a sweet taste, there are usually 2 kinds, namely natural and artificial sweeteners.Â Cyclamate is a type of artificial sweetener that is 30 times sweeter than sucrose.Â The side effects of artificial sweeteners if consumed in excessive amounts can pose a danger to human health.Â Among other things, it can cause urinary tract cancer and migraines.Â This study aims to qualitatively identify cyclamate content in bubble drinks circulating in the city of Denpasar.Â The total number of samples was 30 samples of bubble drinks.Â This research method is a descriptive study with purposive sampling, the results of the data analysis are presented in tabular form without data processing. Sample identification is done by qualitative test.Â The test results showed that 20 of the samples of bubble branded drinks and 10 of the samples of unbranded bubble drinks were safe from cyclamate sweetener content.
PERCEPTION OF CANCER PATIENTS ON CHEMOTHERAPY SIDE EFFECTS
Authors: Indra Rani Lisa , Saputra Bayu 
Published: May 2021

Chemotherapy causesÂ various side effects that can affect the patient's physical or non-physical condition. Patients' perceptions or ratings of these side effects vary. This study aimedÂ to identify cancer patients' perceptions of the side effects of chemotherapy they are undergoing. The descriptive study was conducted on 84 samples, namely cancer patients aged more than 20 years who had undergone chemotherapy at least once before. Data collectionÂ using a questionnaire that has been tested for validity and reliability. Data analysis was carried out descriptively with frequency distribution.Â The results showed that the perception of the physical side effects of chemotherapy that was considered very disturbing by the patient (severe symptoms) was nausea (59.5%), feeling of weakness (36.9%), hair loss (35.7%), vomiting. (29.8%), loss of appetite (28.6%). %), weight loss (27.4%), insomnia and skin discoloration (19% each), headache (16.7%) and fever (15.5%). When the perception of non-physical side effects was fear of death, affecting work/household dutiesÂ and feeling fear (15.5% each), feeling anxiousÂ about my life, and the presence of family members I have to take careÂ (14.3% each). The most disturbing side effects of chemotherapy are physical problems. The health service is expected to increaseÂ interventions to minimize the side effects of chemotherapy.Â
Pulmonary involvement in connective tissue disease due to Coronavirus 19: a case report
Authors: TOPALOĞLU Ömer Faruk , ÖZER Halil , KILINÇER Abidin , UYSAL Emine 
Published: May 2021

Coronavirus disease (COVID-19) is a disease caused by the new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging in Wuhan, China's Hubei province. The epidemic spread exponentially across the world and became a pandemic [1-3]. Fever, dry cough, headache, and shortness of breath all typical symptoms, and can lead to death with acute respiratory distress syndrome. Diabetes mellitus, hypertension, coronary heart disease, chronic obstructive pulmonary disease and chronic kidney disease tend to be major risk factors for mortality [4]. Real-time fluorescence reverse transcription- polymerase chain reaction (RT-PCR) is the preferred initial and reference diagnostic test for COVID-19. Chest computed tomography (CT) has gained importance due to the long result time and false negativity of the RT-PCR test [5, 6]. Typical imaging findings for COVID-19 pneumonia are peripheral, bilateral, ground glass opacities with or without consolidation, and the differential diagnosis comprises influenza pneumonia, organizing pneumonia, drug toxicity, and connective tissue disease [7].
Due to immune dysfunction, steroid usage and immunotherapy, connective tissue diseases are vulnerable to viral infections. Few studies have identified the presence of concurrent COVID-19 in patients with connective tissue diseases [8, 9]. In this article, we aimed to present the chest CT findings of a patient with connective tissue diseases who received immunosuppressed therapy
Does the fibromyalgia affect the quality of life in the patients with inflammatory bowel disease
Authors: DİLEKÇİ Erdal , CAN Güray , GÜRLER Müjgan , ADEMOĞLU DİLEKÇİ Esra Nur , AKDOĞAN KAYHAN Meral 
Published: May 2021

Background and aims: Data on the soft tissue rheumatism, especially fibromyalgia syndrome is limited in inflammatory bowel disease. Our aim in our study is to determine the prevalence of fibromyalgia syndrome and to evaluate the impact of it on quality of life in inflammatory bowel disease.
Methods: 60 ulcerative colitis and 34 Crohn's disease patients were included. 2010/2011 and 2016 American College of Rheumatology criteria were used for fibromyalgia syndrome diagnosis. Fibromyalgia impact survey was applied to the all patients.
Results: According to the American Colloge of Rheumatology-2010/2011 criteria, fibromyalgia syndrome frequencies were determined as 29.8% in inflammatory bowel disease, 23.4% in Crohn’s disease and 33.3% in ulcerative colitis (P ˃ 0.05). The frequency of fibromyalgia syndrome was significantly higher in inflammatory bowel disease and especially more in female. There was no significant difference between ulcerative colitis and Crohn’s disease in terms of widespread-pain-index, somatic-symptom-severity and fibromyalgia syndrome scores. Fibromyalgia impact scores were found significantly higher in those with fibromyalgia syndrome in inflammatory bowel disease, ulcerative colitis and Crohn’s disease.
Conclusions: This is the first study to show the frequency of fibromyalgia syndrome in patients with inflammatory bowel disease in Turkish population. Fibromyalgia syndrome has been shown to be increased in inflammatory bowel disease patients and more in ulcerative colitis and female. The quality of life is more affected in inflammatory bowel disease patients with fibromyalgia syndrome.
A Magyar Honvédség csapategészségügyének telemedicinális fejlesztési lehetőségei
Authors: Matusz Márk Péter 
Published: May 2021

A cikkben ismertetem a hazai civil egészségügyi ellátó intézményekben használt főbb telemedicinális eszközöket. Azonosítom és megnevezem a működtetésük során szerzett elsődleges tapasztalatokat. Ezen gyakorlati ismeretek felhasználásával összeállítom és bemutatom a Magyar Honvédség egészségügyi szolgálatánál bevezetésre javasolt telemedicinális koncepciót. Végül a megtervezett telemedicinális rendszer potenciális előnyeit és rizikófaktorait is azonosítom.
Analysis of the Prognostic Value and Potential Molecular Mechanisms of TREM-1 Overexpression in Papillary Thyroid Cancer via Bioinformatics Methods
Authors: Xie Zhenyu , Li Xin , He Yuzhen , Wu Song , Wang Shiyue , Sun Jianjian , He Yuchen , Lun Yu , Xin Shijie , Zhang Jian 
Published: May 2021

BackgroundTriggering receptor expressed on myeloid cells-1 (TREM-1) has been reported as a biomarker in many cancers. However, the biological function of TREM-1 in papillary thyroid carcinoma (PTC) remains unknown.MethodsWe obtained TREM-1 expression data from The Cancer Genome Atlas (TCGA) database. Enrichment analysis of coexpressed genes and TREM-1 methylation analysis were performed via LinkedOmics. The correlations between TREM-1 and immune infiltrates were investigated via ESTIMATE, TIMER and TISIDB. We analyzed the association of TREM-1 expression with pan-cancer overall survival via Gene Expression Profiling Interactive Analysis (GEPIA).ResultsTREM-1 has lower methylation levels and higher expression levels in PTC tissues compared to normal tissues. TREM-1 expression is significantly associated with poor prognosis, advanced T classification, advanced N classification, and an increased incidence of BRCA2 and BRAF mutations. Genes coexpressed with TREM-1 primarily participate in immune-related pathways. TREM-1 expression is positively correlated with immune infiltration, tumor progression and poor overall survival across cancers.ConclusionsTREM-1 is a good prognostic and diagnostic biomarker in PTC. TREM-1 may promote thyroid cancer progression through immune-related pathways. Methylation may act as an upstream regulator of TREM-1 expression and biological function. Additionally, TREM-1 has broad prognostic value in a pan-cancer cohort.
Effect of COVID-19 on Male Reproductive System – A Systematic Review
Authors: He Yanfei , Wang Jie , Ren Junlin , Zhao Yubo , Chen Jing , Chen Xuejiao 
Published: May 2021

BackgroundAngiotensin-converting enzyme II (ACE2), a receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to enter host cells, is widely expressed in testes and prostate tissues. The testis and prostate produce semen. At present, there are contradictory reports about whether SARS-CoV-2 can exist in the semen of infected men.ObjectiveTo provide a comprehensive overview of the topic of whether COVID-19 can impact on male reproductive system.MethodsWe reviewed the relevant publications on the possible impact of Coronavirus Disease 2019 (COVID-19) on male reproductive system and summarized the latest and most important research results so far. Literature published in English from December 2019 to January 31, 2021 regarding the existence of SARS-CoV-2 in semen, testis, and prostatic fluid and the effects of COVID-19 on male reproductive were included.ResultsWe identified 28 related studies, only one of which reported the presence of SARS-CoV-2 in semen. The study found that the semen quality of patients with moderate infection was lower than that of patients with mild infection and healthy controls. The impaired semen quality may be related to fever and inflammation. Pathological analysis of the testis/epididymis showed that SARS-CoV-2 viral particles were positive in 10 testicular samples, and the spermatogenic function of the testis was impaired. All 94 expressed prostatic secretion (EPS) samples were negative for SARS-CoV-2 RNA.ConclusionThe likelihood of SARS-CoV-2 in the semen of COVID-19 patients is very small, and semen should rarely be regarded as a carrier of SARS-CoV-2 genetic material. However, COVID-19 may cause testicular spermatogenic dysfunction via immune or inflammatory reactions. Long-term follow-up is needed for COVID-19 male patients and fetuses conceived during the father’s infection period.
Association of Preoperative NANOG-Positive Circulating Tumor Cell Levels With Recurrence of Hepatocellular Carcinoma
Authors: Lei Yongrong , Wang Xishu , Sun Heng , Fu Yuna , Tian Yichen , Yang Ludi , Wang Jianhua , Xia Feng 
Published: May 2021

BackgroundCancer stem cells (CSCs) and Circulating tumor cells (CTCs) have been proposed as fundamental causes for the recurrence of hepatocellular carcinoma (HCC). CTCs isolated from patients with HCC illustrate a unique Nanog expression profile analysis. The aim of this study was to enhance the prediction of recurrence and prognosis of the CTC phenotype in patients with HCC by combining Nanog expression into a combined forecasting model.Subjects, Materials, and MethodsWe collected 320 blood samples from 160 patients with HCC cancer before surgery and used CanPatrol™ CTC enrichment technology and in situ hybridization (ISH) to enrich and detect CTCs and CSCs. Nanog expression in all CTCs was also determined. In addition, RT-PCR and immunohistochemistry were used to study the expression of Nanog, E-Cadherin, and N-Cadherin in liver cancer tissues and to conduct clinical correlation studies.ResultsThe numbers of EpCAM mRNA+ CTCs and Nanog mRNA+ CTCs were strongly correlated with postoperative HCC recurrence (CTC number (P = 0.03), the total number of mixed CTCS (P = 0.02), and Nanog&gt; 6.7 (P = 0.001), with Nanog &gt; 6.7 (P = 0.0003, HR = 2.33) being the most crucial marker. There are significant differences in the expression of Nanog on different types of CTC: most Epithelial CTCs do not express Nanog, while most of Mixed CTC and Mesenchymal CTC express Nanog, and their positive rates are 38.7%, 66.7%, and 88.7%, respectively, (P=0.0001). Moreover, both CTC (≤/&gt; 13.3) and Nanog (≤/&gt;6.7) expression were significantly correlated with BCLC stage, vascular invasion, tumor size, and Hbv-DNA (all P &lt; 0.05). In the young group and the old group, patients with higher Nanog expression had a higher recurrence rate. (P &lt; 0.001).ConclusionsThe number of Nanog-positive cells showed positive correlation with the poor prognosis of HCC patients. The detection and analysis of CTC markers (EpCAM and CK8, 18, CD45 Vimentin,Twist and 19) and CSCs markers (NANOG) are of great value in the evaluation of tumor progression.
Wavelength Selection Method Based on Absorbance Value Optimization to Near-Infrared Spectroscopic Analysis
Authors: Yao Lijun , Shi Xiaowen , Pan Tao , Chen Jiemei 
Published: May 2021

Regarding absorption spectrum, high absorption corresponds to low light transmittance and relatively loud noise, whereas low absorption corresponds to low information content, which interferes with the modeling of spectral analysis. Appropriate absorbance level is necessary to improve spectral information content and reduces noise level. In this study, based on the selection of the upper and lower bounds of absorbance, the absorbance value optimization partial least squares (AVO-PLS) method was proposed for appropriate wavelength model selection. Near-infrared spectroscopic analysis of hyperlipidemia indicators, namely, total cholesterol (TC), and triglyceride (TG), was conducted to validate the predicted performance of AVO-PLS. Well-performed wavelength selection methods, namely, moving-window PLS (MW-PLS) of continuous type-and successive projections algorithm (SPA) of discrete type, were also conducted for comparison. The spectra were first corrected using Savitzky–Golay smoothing. Modeling was performed based on the multiple partitioning of calibration and prediction sets to avoid data over-fitting and achieve parameter stability. The selected absorbance ranged from 0.45 to 0.86 for TC and from 0.45 to 0.92 for TG, and the corresponding waveband combinations were 1,376–1,388 and 1,560–1840 nm for TC and 1,376–1,390 and 1,552–1,846 nm for TG. Among them, the waveband combination of TG covers TC’s one, and can be used for the high-precision cooperativity analysis of the two indicators. Using the independent validation samples, the RMSEP and RP of 0.164 mmol l−1 and 0.990 for TC and 0.096 mmol l−1 and 0.997 for TG were obtained by the cooperativity model. And the sensitivity and specificity for hyperlipidemia were 98.0 and 100%, respectively. These values were better than those of MW-PLS and SPA. Importantly, the proposed AVO-PLS is a novel multi-band optimization approach for improving prediction performance and applicability. This method is expected to obtain more applications.
Investigation of Anxiety, Depression, Stress and Related Factors in the Primary Caregivers of Inpatients with Cancer
Authors: Xu Hong Hong , Xue Ruo Tong , Cheng Yi , Zhang Yu Jie , Rao Jie , Liu Mei , Yu Shi Ying , Liu Ling Xiang , Liu Yi Qian , Shu Yong Qian , Yang Liu Qing , Shi Han Ping 
Published: May 2021

Abstract:

Objectives
To explore the anxiety, depression, stress and related factors in the primary caregivers of inpatients with cancer.

Methods
A total of 235 selected caregivers of inpatients with cancer were included as the research subjects, and the Depression-Anxiety-Stress Self-Rating Scale 21 (DASS-21) was used to evaluate their depression, anxiety and stress. The data were statistically analyzed using SPSS 25.0 software.

Results
The study showed that the caregivers of cancer patients had different levels of depression, anxiety and stress, but all rates were above the normal range, with 51.7%, 56.0% and 34.9% of subjects respectively reporting these conditions. In addition, the above indicators were correlated with the caregivers’ gender, age, relationship with the cancer patients, the family’s economic status, religious belief and duration of caregiving: being female (T-Statistic = -2.061, P = 0.040) and having a low income (F = 2.627, P = 0.035) were positively correlated with the caregivers’ stress level. Having a low income (F = 2.804, P = 0.027) was also positively correlated with the depression scores. When the caregivers were the patient’s parents, they had higher levels of anxiety (F = 2.429, P = 0.036) than caregivers in other relationships. The results of a linear correlation analysis showed that the depression of caregivers was negatively correlated with the family’s economic status (r value = -0.244, P < 0.01) and positively correlated with the duration of caregiving (r = 0.138, P < 0.05). The anxiety score was positively correlated with the caregivers’ age (r = 0.141, P < 0.05) and duration of caregiving (R = 0.132, P < 0.05), but negatively correlated with the family’s economic status (r = -0.187, P < 0.01). The stress level was positively correlated with the caregivers’ gender (r = 0.137, P < 0.05), age (r = 0.210, P < 0.01), duration of caregiving (r = 0.171, P < 0.01) and current job status (r = 0.165, P < 0.05), but negatively correlated with the family’s economic status (r = -0.202, P < 0.01). The results of a multiple stepwise regression showed that age and religious belief were significant predictors of stress, while the family’s economic status was a significant predictor of depression, and age was a significant predictor of anxiety.

Conclusion
The caregivers of hospitalized cancer patients showed varying degrees of anxiety, depression and stress, according the psychological assessments; the provision or interventions might be helpful for these individuals.
Проєктування гравітаційно-коловоротних гес для малих річок Прикарпаття
Authors: Ващишак І. Р. 
Published: May 2021

Розглянуто ефективність використання малої гідроенергетики у світі та перспективи її розвитку в Україні. Зазначено, що гідропотенціал великої частини річок Прикарпаття через незначні напори вздовж їх русел для виробництва електроенергії використовують рідко. Для генерації електроенергії малими річками Прикарпаття пропонуємо застосувати гравітаційно-коловоротну ГЕС, яка працює за допомогою водяного виру. Така ГЕС може генерувати електроенергію значної потужності на ділянках річки з незначними напорами. Перевагами гравітаційно-коловоротних ГЕС також є їх мінімальний вплив на живі організми річки через низьку частоту обертів турбін і відсутність замерзання води взимку. Обґрунтовано вибір оптимального способу розміщення гідротурбіни у вирі гравітаційно-коловоротної ГЕС, шляхом встановлення колеса гідротурбіни в нижній частині виру. Електрогенератор і редуктор розміщуються на зовнішній поверхні ГЕС і з'єднуються з гідротурбіною за допомогою валу. Перевагою цього способу встановлення гідротурбіни є те, що вона практично не впливає на формування виру. За таких умов вся енергія виру використовується для обертання гідротурбіни, бо практично весь об'єм води контактує з її лопатками. Запропонований спосіб дає змогу зменшити до мінімуму розміри робочого колеса гідротурбіни та отримати високий ККД. Наведено методику розрахунку гідравлічних характеристик гравітаційно-коловоротної ГЕС для отримання електричних (потужність, частота) параметрів її генератора відповідно до заданих витрати та напору водяного потоку ділянки річки. Наведено умови для утворення виру. Для зменшення негативного впливу на стік річки запропоновано використовувати для роботи малої ГЕС не більше 25 % її середнього багаторічного стоку. За наведеною методикою розраховано каскад з 5-ти малих ГЕС для ділянки річки Бистриця Надвірнянська (м. Івано-Франківськ). Розраховано ступінь редукції редукторів для генераторів ГЕС. Місця для встановлення ГЕС вибирали з найбільшим перепадом висот вздовж русла річки та в місцях зливання русла з меншими річками. Довжина ділянки ріки для розміщення цих ГЕС становить 6 км. Підібрано гідротурбіни з генераторами та системами автоматики для використання їх у складі розрахованих малих гравітаційно-коловоротних ГЕС. Об'єднання гравітаційно-коловоротних ГЕС у загальну енергетичну систему дасть змогу отримати значну електричну генерацію з ділянок річок, гідроенергетичний потенціал яких раніше не використовувався.