bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connecting different heart diseases through intercellular communication
Authors: Martins-Marques Tania 
Published: September 2021

ABSTRACT
Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell–extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example.
This Review has an associated Future Leader to Watch interview with the author.
Time-varying motor control strategy for proximal-to-distal sequential energy distribution: insights from baseball pitching
Authors: Naito Kozo 
Published: September 2021

ABSTRACT
The importance of a proximal-to-distal (P–D) sequential motion in baseball pitching is generally accepted; however, the mechanisms behind this sequential motion and motor control theories that explain which factor transfers mechanical energy between the trunk and arm segments are not completely understood. This study aimed to identify the energy distribution mechanisms among the segments and determine the effect of the P–D sequence on the mechanical efficiency of the throwing movement, focusing on the time-varying motor control. The throwing motions of 16 male collegiate baseball pitchers were measured by a motion capture system. An induced power analysis was used to decompose the system mechanical energy into its muscular and interactive torque-dependent components. The results showed that the P–D sequential energy flow during the movement was mainly attributed to three different joint controls of the energy generation and muscular torque- and centrifugal force-induced energy transfer. The trunk muscular torques provided the primary energy sources of the system mechanical energy, and the shoulder and elbow joints played the roles of the energy-transfer effect. The mechanical energy expenditure on the throwing hand and ball accounted for 72.7% of the total muscle work generated by the trunk and arm joints (329.2 J). In conclusion, the P–D sequence of the throwing motion is an effective way to utilize the proximal joints as the energy source and reduce muscular work production of the distal joints. This movement control assists in efficient throwing, and is consistent with the theory of the leading joint hypothesis.
The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1
Authors: Kusmardi Kusmardi , Wiyarta Elvan , Rusdi Numlil Khaira , Maulana Andi Muh. , Estuningtyas Ari , Sunaryo Hadi 
Published: September 2021

Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE) on the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and epithelial cadherins (E-Cadherin) in breast cancer. Methods: In this true-experimental in vivo study, 24 Sprague-Dawley rats that were induced by 7,12-Dimethylbenz[a]anthracene (DMBA), were used. Based on the therapy given, the groups were divided into, normal, positive control (PC), negative control (NC), adjuvant, curative, and preventive. Lunasin was extracted from soybean seeds of the Grobogan variety in Indonesia. Tissue samples were obtained, processed, stained with anti-ICAM-1 and anti-E-Cadherin antibodies, examined under a microscope, and quantified using H-score. The data were analyzed using ANOVA, which was then followed by Duncan's test. Results: Statistically significant difference in ICAM-1 expression was observed between the following groups: adjuvant and NC, normal and NC, PC and NC, adjuvant and preventive, normal and preventive, PC and preventive, adjuvant and curative, normal and curative, PC and curative. E-Cadherin expression was significantly different between preventive and NC, adjuvant and NC, PC and NC, normal and NC, adjuvant and curative, PC and curative, normal and curative, normal and preventive. Significant negative correlation was found between ICAM-1 and E-Cadherin [-0.616 (-0.8165; -0.283)] with p = 0.001. Conclusion: Preventive dose of LE was able to reduce ICAM-1 expression while increasing E-Cadherin expression.
Assessment of personality disorder in the ICD-11 diagnostic system: Polish validation of the Personality Inventory for ICD-11
Authors: Cieciuch Jan , Łakuta Patryk , Strus Włodzimierz , Oltmanns Joshua R. , Widiger Thomas 
Published: September 2021

Cel pracyArtykuł prezentuje wyniki badania, którego celem była polska adaptacja Inwentarza Osobowości PiCD, skonstruowanego do pomiaru patologicznych cech w ramach nowego dymensjonalnego modelu zaburzeń osobowości, zaproponowanego w ICD-11.MetodaBadanie zostało przeprowadzone w nieklinicznej grupie N = 597 dorosłych (51,4% kobiet, M = 30,24 lat, SD = 12,07 lat). W celu oszacowania trafności zbieżnej i różnicowej wykorzystano Inwentarz Osobowości PID-5 (Personality Inventory for DSM-5; Krueger et al., 2012) oraz Inwentarz BFI2 (Big Five Inventory-2; Soto & John, 2017).WynikiWyniki wskazują na to, że polska adaptacja PiCD jest rzetelna i trafna. Alfa Cronbacha dla skal PiCD waha się od 0,77 do 0,87 (M⍺ = 0,82). Została potwierdzona czteroczynnikowa struktura PiCD z trzema jednobiegunowymi czynnikami (Negatywny Afekt, Izolacja i Dyssocjalność) i jednym dwubiegunowym czynnikiem (Anankastyczność vs Rozhamowanie). Wszystkie cechy osobowości, mierzone za pomocą PiCD, wiążą się w teoretycznie oczekiwany sposób z dysfunkcjonalnymi cechami mierzonymi przez PID-5 oraz cechami osobowości zdrowej, mierzonymi przez BFI-2, zarówno w analizie korelacji, jak i w analizie czynnikowej.WnioskiUzyskane dane potwierdzają satysfakcjonującą spójność wewnętrzną, trafność czynnikową oraz trafność zbieżną i różnicową polskiej adaptacji PiCD w grupie nieklinicznej.
Investment Strategies for Sourcing a New Technology in the Presence of a Mature Technology
Authors: Zhang Wei , Lee Hsiao-Hui 
Published: September 2021

To stay competitive, high-technology manufacturers not only frequently source new technologies from their suppliers, but also financially support the development of these new technologies into component products or production tools. We consider a manufacturer that can either source a new but immature technology from a financially constrained supplier, or source a mature technology from an existing supplier if and only if the development of the new technology fails. To support the new technology, the manufacturer can choose to inject capital in the form of an equity or loan. The investment strategy not only affects the new supplier’s development effort and the probability of technical success (PTS), but also affects the existing supplier’s effort to improve the mature technology, which presents the manufacturer with a trade-off. Following the debt financing literature, we find that a loan contract is associated with a cost-shifting effect and often leads to a higher PTS. However, because the manufacturer not only maintains an investment but also a procurement relationship with the new supplier, we find a profit-sharing effect associated with an equity investment, which does not exist in the traditional equity issuance literature. In particular, we show that the profit-sharing effect can dominate the cost-shifting effect and lead to a higher PTS when the new supplier’s technological capability is sufficiently high. Nonetheless, we also show that the strategy that derives a higher PTS does not necessarily generate a higher payoff for the manufacturer. On the one hand, a loan can be preferred even when it leads to a lower PTS because the cost-shifting effect allows the manufacturer to offer a sufficiently low procurement payment while maintaining a sufficiently high PTS. On the other hand, when the existing supplier is very capable of reducing its costs, a loan can over-incentivize the new supplier to exert excessive effort and backfire. This paper was accepted by Charles Corbett, operations management.
Spillovers from Online Engagement: How a Newspaper Subscriber’s Activation of Digital Paywall Access Affects Her Retention and Subscription Revenue
Authors: Pattabhiramaiah Adithya , Overby Eric , Xu Lizhen 
Published: September 2021

Newspapers are increasingly reliant on subscription revenue as advertising spend shifts to online platforms. Many newspapers have implemented paywalls in an attempt to boost subscription revenue. We study whether and how paywalls can help newspapers boost subscription revenue by retaining existing subscribers. Most major newspapers offer free access to paywalled content to subscribers to the print edition, which may help the newspaper retain subscribers by making their subscriptions more valuable. We leverage variation in whether and when existing subscribers activated access to the paywall of a top 30 North American newspaper. Our identification strategy accounts for self-selection in subscribers’ decisions to activate paywall access. We find that a subscriber’s activation of digital access decreases the risk of her canceling her subscription by about 31% and increases her subscription revenue by 7%–12%. In other words, digital activation improves subscriber retention and the associated subscription revenue. This suggests a crosschannel spillover in which the online product (the paywalled website) increases customers’ valuation for the offline product (the printed newspaper). Our results have implications not only for the newspaper industry but also for firms in other industries that offer subscribers to one product free or subsidized access to a complementary product. This paper was accepted by Kartik Hosanagar, information systems.
Non-medical prescribing in primary care in the United Kingdom: an overview of the current literature
Authors: Armstrong Amanda , Manfrin Andrea , Gibson Josephine 
Published: September 2021

Background: Non-medical prescribers (NMPs) are perceived as a complement to busy general practice in primary care. Aim: To conduct an overview of the literature available on the role and impact of non-medical prescribing (NMP) on primary care patients. Method: The search was conducted using multiple databases to find articles published between January 2015-January 2021. Inclusion criteria: NMPs in primary care in the United Kingdom, written in English language. Exclusion criteria: research conducted in secondary care or outside the UK. Findings: 285 studies were identified; 15 were eligible for critical appraisal. Key themes were: NMP's positive perceptions were autonomy, job satisfaction and colleague support; negative perceptions included risk, lack of continuous professional development (CPD), organisational support. Conclusion: By reviewing the perceptions of NMPs in primary care, organisations can ensure when employing new NMPs that the adequate CPD and support is in place. Thereby reducing NMPs concerns about the ligation risk of prescribing.
Spectral shaping of fiber Bragg gratings based on non-rigid origami
Authors: Xu Zhu-Long , Wang Yu-Han , Chuang Kuo-Chih 
Published: September 2021

We present a spectrum-tunable fiber Bragg grating (FBG) based on a unique compress-twist deformation mode of non-rigid origami. By applying axial displacement on the FBG-bonded Kresling-ori, a non-uniform strain field emerges. The mechanics-induced non-uniform strain can shift the wavelength of an apodized unchirped FBG and/or transform an apodized unchirped FBG to a chirped one. For the spectrum-shaping mode, the bandwidth of the FBG was tuned from 0.32 nm up to 2.9 nm, measured at the−6dBlevel. For the wavelength-shift mode, a maximum wavelength shift of 0.6 nm can be achieved.
Using machine learning and big data to explore the drug resistance landscape in HIV
Authors: Blassel Luc , Tostevin Anna , Villabona-Arenas Christian Julian , Peeters Martine , Hué Stéphane , Gascuel Olivier ,   On behalf of the UK HIV Drug Resistance Database
Published: September 2021

Drug resistance mutations (DRMs) appear in HIV under treatment pressure. DRMs are commonly transmitted to naive patients. The standard approach to reveal new DRMs is to test for significant frequency differences of mutations between treated and naive patients. However, we then consider each mutation individually and cannot hope to study interactions between several mutations. Here, we aim to leverage the ever-growing quantity of high-quality sequence data and machine learning methods to study such interactions (i.e. epistasis), as well as try to find new DRMs.We trained classifiers to discriminate between Reverse Transcriptase Inhibitor (RTI)-experienced and RTI-naive samples on a large HIV-1 reverse transcriptase (RT) sequence dataset from the UK (n≈ 55, 000), using all observed mutations as binary representation features. To assess the robustness of our findings, our classifiers were evaluated on independent data sets, both from the UK and Africa. Important representation features for each classifier were then extracted as potential DRMs. To find novel DRMs, we repeated this process by removing either features or samples associated to known DRMs.When keeping all known resistance signal, we detected sufficiently prevalent known DRMs, thus validating the approach. When removing features corresponding to known DRMs, our classifiers retained some prediction accuracy, and six new mutations significantly associated with resistance were identified. These six mutations have a low genetic barrier, are correlated to known DRMs, and are spatially close to either the RT active site or the regulatory binding pocket. When removing both known DRM features and sequences containing at least one known DRM, our classifiers lose all prediction accuracy. These results likely indicate that all mutations directly conferring resistance have been found, and that our newly discovered DRMs are accessory or compensatory mutations. Moreover, apart from the accessory nature of the relationships we found, we did not find any significant signal of further, more subtle epistasis combining several mutations which individually do not seem to confer any resistance.
Resultados 2013-2019 en las saber-pro: revisión para consolidar estrategias en la formación tecnológica
Authors: Rodríguez-Montaña Fery Patricia , Romero-Mestre Henry Alfonso , Burgos-Díaz Jaime Alfredo 
Published: September 2021

En el siguiente documento se realiza un análisis de resultados de las pruebas Saber T y T en el ciclo tecnológico y Saber Pro en el ciclo de Ingeniería, con datos emanados por el Instituto Colombiano Para la Evaluación de la Educación (Icfes), de los estudiantes de Tecnología en Electrónica, Ingeniería en Control e Ingeniería en Telecomunicaciones de la Universidad Distrital Francisco José de Caldas, durante el periodo de 2013-2019. Inicialmente se extrae la información de resultados publicada para cada cohorte de Estudiantes durante el intervalo de tiempo descrito anteriormente. Posteriormente con la ayuda de herramientas estadísticas se realiza un balance en cuanto al desempeño en las diferentes competencias genéricas y específicas, que permite comparar los desempeños en el tiempo respecto al programa, a los programas afines que constituyen un grupo de referencia, a los programas de la Institución y a la población nacional. En la parte final se hace un análisis de las tendencias obtenidas, con el cual se resaltan los desempeños altos, identifican las oportunidades de mejora y se proponen estrategias que buscan incrementar la calidad de la formación desde el nivel tecnológico de los estudiantes de estas carreras.
Universal scanning-free initiation of eukaryote protein translation–a new normal
Authors: Auparakkitanon Saranya , Wilairat Prapon 
Published: September 2021

Abstract
A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5′-untranslated region (5′-UTR) by a ribosome initiation complex to enable bound Met-tRNAi access to the initiation codon located further downstream. Here, we propose a universal scanning-free translation initiation model that is independent of 5′-UTR length and applicable to both 5′-m7G (capped) and uncapped mRNAs.
Recent developments in photocatalytic degradation of insecticides and pesticides
Authors: Singh Santosh Kumar , Mishra Pradeep Kumar , Upadhyay Siddh Nath 
Published: September 2021

Abstract
Widespread use of pesticides in agricultural and domestic sectors and their long half-life have led to their accumulation in the environment beyond permissible limits. Advanced chemical oxidation methods including photocatalytic degradation are being widely investigated for their mineralization. Photocatalytic degradation is the most promising method for degrading pesticides as well as other organic pollutants. Titanium dioxide with or without modification has been widely used as the photocatalyst. Some research groups have also tried other photocatalysts. This review presents a critical summary of the research results reported during the past two decades as well as the scope for future research in this area.
Revisiting German two-way prepositions
Authors: Jach Daniel 
Published: September 2021

AbstractGerman two-way prepositions have long troubled grammar writing. Unlike most other German prepositions, they occur with both accusative and dative case. Their case is difficult to predict and has been attributed to different underlying meaning construals. Recent exploratory corpus studies propose that, in addition, their case depends on multiple co-occurring contextual variables. Following this approach, this study uses multivariate regression and collostructional analysis to investigate what determines the case of two-way prepositions in a large sample of authentic language use. Based on the results, this study then attempts to provide a usage-based description of the case of two-way prepositions. Contrary to expectations, none of the proposed variables had much influence on case, suggesting that the effects observed in the literature only hold for specific contexts. Instead, the results indicated associations of accusative and dative with individual prepositions and specific lexical items in the context. Framed in terms of usage-based construction grammar, this is interpreted as item-specific constructional prototypes that emerge from typical usage patterns and, once established, determine case based on form-meaning overlap with the current context of use. In line with recent usage-based research on grammar, a first attempt is made to describe case as part of a network of associative links between constructions and lexical items.
IDENTITY FOCUSED ADAPTATION OF NEWCOMERS IN ORGANIZATIONS: RESOURSE FOR PERSONNEL MANAGEMENT
Authors:   National Research University, Moscow, Russia Higher School of Economics Faculty of Social Science School of Public Administration and Department of Psychology, Ivanova Natalia , Klimova Anna 
Published: September 2021

The report addresses the issue of adaptation of newcomers in organizations. This problem is very important now in business and public organizations according to the problem of labor productivity, staff turnover, corporate culture etc. In spite of obvious importance of the adaptation in organization, the studies of this problem require new approaches and methods. Mechanisms are explored that help to retain the staff in organization and to create a desire to continue its activities in this organization. The research is implemented to the framework of the business-psychological approach (S Benton, N. Ivanova, theory of social identity (H. Tajfel, J.C. Turner), concepts of adaptation (T. Bazarov, N. Volkova etc.). Adaptation of newcomers is considered as a natural stage of professional and social self-determination of the individual, as overcoming the identity crisis and identity forming process. In the course of adaptation, an identity is formed that is adequate in relation to the new social roles and goals of activity. The purpose of the study: to develop the identity focused adaptation model, to test the role of this model in the work with newcomers in organization. Methodology: questionnaire (N= 109), Job Satisfaction Survey (N=15), case study in organizations. Results: The role of information and psychological support of a novice from the manager, mentor and team while including a specialist in joint activities is revealed. The directions of improving the system of adaptation of newcomers in the organization are highlighted. An identity focused adaptation model has been developed, which includes the following components: A)	Preliminary information to newcomers: preparatory briefing about the company; detailed briefing about the company's rules and regulations. B)	Information about newcomers to colleagues: about the new employee, his workplace, the tasks of his adaptation, the appointment of a mentor. C)	Communications of the mentor: checking the workplace, the initial conversation, monitoring the problems and successes, the employee's initiation into the company's affairs. D)	Communications of the manager: aimed at reducing the uncertainty of the newcomer in the first days of work. E)	Communication of newcomers: questions, feedback, ideas, doubts, wishes. Results of this research can be useful for management, counseling and coaching for development of newcomer’s identity, loyalty, and performance. Keywords: business psychology, identity focused adaptation model, personnel management, loyalty, adaptation of personnel, social identity, strategy of communication.