bluuebunny/crossref_metadata_2025_split huggingface dataset:
A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Authors: Gross Sean M. , Dane Mark A. , Smith Rebecca L. , Devlin Kaylyn , McLean Ian , Derrick Daniel , Mills Caitlin , Subramanian Kartik , London Alexandra B. , Torre Denis , Erdem Cemal , Lyons Nicholas , Natoli Ted , Pessa Sarah , Lu Xiaodong , Mullahoo James , Li Jonathan , Adam Miriam , Wassie Brook , Liu Moqing , Kilburn David , Liby Tiera A. , Bucher Elmar , Sanchez-Aguila Crystal , Daily Kenneth , Omberg Larsson , Wang Yunguan , Jacobson Connor , Yapp Clarence , Chung Mirra , Vidovic Dusica , Lu Yiling , Schurer Stephan , Lee Albert , Pillai Ajay , Subramanian Aravind , Papanastasiou Malvina , Fraenkel Ernest , Feiler Heidi S. , Mills Gordon B. , Jaffe Jake , Ma’ayan Avi , Birtwistle Marc R. , Sorger Peter K. , Korkola James E. , Gray Joe W. , Heiser Laura M. 
Published: August 2021

SUMMARYThe phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic changes, we generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and development of novel computational methods (synapse.org/LINCS_MCF10A). In illustrative analyses, we demonstrate how this dataset can be used to discover functionally related molecular features linked to specific cellular phenotypes.
Rapid Lifestyle Prototyping: Assessment of Infrared Spectroscopic Blood Responses for Short-term Lifestyle Interventions
Authors: Rouholiman Dara , Andries Erik , Dobrota Sylvie D , Macaulay Hershel , Messerschmidt Robert G. , Quertermous Thomas 
Published: August 2021

AbstractBackgroundAt the present time, optimization of dietary and fitness practices are inadequately addressed in the clinical setting, and poorly documented through research studies investigating response to surrogate disease markers. Identifying and quantifying the personal response to lifestyle interventions requires a new tool and a new measurement metric.MethodsIn this prospective observational study, COR.RELATE study, we investigated the effect of four lifestyle interventions, each spanning 21 days and consisting of seven validated practices, in a healthy population. We used a novel at-home near-infrared spectrometer (wavelength 1600-2450 nm), COR console, to measure the spectral blood changes in a cohort of 178 healthy males and females who participated in four 21-day cycles of lifestyle programs. In the first round, study participants also completed dried blood spot cards, provided by omega quant, at the start and end of their program.ResultsWe analyzed 1,870 infrared spectroscopy samples from 178 participants (131 males and 47 females) who participated in the first four programs of COR.RELATE. We found on average 79.75% of the participants are responsive to one or more of the COR programs. We describe an algorithmic approach, ranking personal responses to different nutrition and fitness interventions.ConclusionThe COR console and data analytics enables the use of a novel near-infrared based metric--which we call the COR Blood Response Pattern (BRP)--to measure individual response to lifestyle change, and has the sensitivity to discern, classify, and rank the success of rapid lifestyle interventions in terms of the correlated spectroscopic response they produce. Rapid Lifestyle Prototyping is a new concept in consumer life optimization and improvement - the ability to know in no more than 21 days whether a particular single, or set of, lifestyle practices is going to evoke a strong response for an individual and therefore if it is worth continuing that practice in their quest for deep optimization and life improvement.
Anti-CD38 therapy impairs SARS-CoV-2 vaccine response in multiple myeloma patients
Authors: Henriquez S. , Zerbit J. , Bruel T. , Ouedrani A. , Planas D. , Deschamps P. , Staropoli I. , Hadjadj J. , Varet B. , Suarez F. , Ermark N. , Bouscary D. , Willems L. , Fouquet G. , Decroocq J. , Franchi P. , Deau-Fischer B. , Terrier B. , Tamburini J. , Chatenoud L. , Schwartz O. , Vignon M. 
Published: August 2021

AbstractMultiple myeloma (MM) patients are at risk of fatal outcome after SARS-CoV-2 infection. Preliminary data suggest that MM patients have an impaired response to vaccination. This prospective study analyzed the humoral and cellular immune responses to two doses of BNT162b2 in 72 MM patients, including 48 receiving anti-CD38 immunotherapy. Results evidenced that MM patients display lower levels of SARS-CoV-2 specific IgG and IgA antibodies and decreased neutralization of alpha and delta variants when compared to healthy controls. They also showed decreased numbers of circulating IFNγ-producing Spike SARS-CoV-2 specific T lymphocytes. This defective immune response was particularly marked in patients receiving anti-CD38 immunotherapy. Furthermore, a retrospective investigation of MM patients among COVID-19-related death in the Paris area suggested a limited efficacy of BNT162b2 in patients treated with anti-CD38. Overall, these results show a decreased immunogenicity of BNT162b2 in MM patients and stress the need for novel strategies to improve SARS-CoV-2 prophylaxis in immunocompromised individuals.
Multi-UAV cooperative target tracking via consensus-based guidance vector fields and fuzzy MRAC
Authors: Muslimov Tagir Z. , Munasypov Rustem A. 
Published: August 2021

Purpose
This paper aims to propose a multi-agent approach to adaptive control of fixed-wing unmanned aerial vehicles (UAVs) tracking a moving ground target. The approach implies that the UAVs in a single group must maintain preset phase shift angles while rotating around the target so as to evaluate the target’s movement more accurately. Thus, the controls should ensure that the UAV swarm follows a moving circular path whose center is the target while also attaining and maintaining a circular formation of a specific geometric shape; and the formation control system is capable of self-tuning because the UAV dynamics is uncertain.

Design/methodology/approach
This paper considers two interaction architectures: an open-chain where each UAV only interacts with its neighbors; and a cooperative leader, where the leading UAV is involved in attaining the formation. The cooperative controllers are self-tuned by fuzzy model reference adaptive control (MRAC).

Findings
Using open-chain decentralized architecture allows to have an unlimited number of aircraft in a formation, which is in line with the swarm behavior concept. The approach was tested for efficiency and performance in various scenarios using complete nonlinear flying-wing UAV models equipped with configured standard autopilot models.

Research limitations/implications
Assume the target follows a rectilinear trajectory at a constant speed. The speed is supposed to be known in advance. Another assumption is that the weather is windless.

Originality/value
In contrast to known studies, this one uses Lyapunov guidance vector fields that are direction- and magnitude-nonuniform. The overall cooperative controller structure is based on a decentralized and centralized consensus.
Potential measures towards the reduction of cooling loads of office buildings in Ghana
Authors: Koranteng Christian , Simons Barbara , Gyimah Kwabena Abrokwa 
Published: August 2021

PurposeGiven the climatic context and economic challenge of Ghana in its developmental strides, energy use of office buildings continues to be a task on the economy. Therefore, the study was about finding measures that could reduce cooling loads in 10 office buildings. The paper presents the outcome of a long-term study of the thermal conditions in a selected number of office buildings in Accra and Kumasi, Ghana.Design/methodology/approachThrough long-term monitoring of environmental data, the buildings were consequently modelled in a simulation application. Thereafter, a validation of the simulation models (using regression coefficients, r2 of 0.53–0.90) was undertaken towards finding measures to reduce cooling loads.FindingsThe results showed various potentials of efficient lighting, thermal mass, night ventilation, insulation to attic floors, efficient glazing, blind deployments, etc. in reducing cooling loads in the range of 2–17.5%. By combining the potential measures to study their synergistic effects on the loads, 35, 39 and 38% improvements were achieved for the low-rise, multi-storey and fully glazed office buildings.Originality/valueThese potential measures ought to be incorporated in the design, specification, construction and operation of Ghanaian office buildings to reduce the burden on the economy and the environment. Now more than ever, there is the need for climatic regions to come up with empirical data that could help relieve the world's economies from the post-pandemic stress.
Making more research count: a blockchain enabled one-stop shop for immutable behavioral research
Authors: Hoffmann Christian Hugo 
Published: August 2021

Purpose
The purpose of this paper is to offer a panoramic view at the credibility issues that exist within social sciences research.

Design/methodology/approach
The central argument of this paper is that a joint effort between blockchain and other technologies such as artificial intelligence (AI) and deep learning and how they can prevent scientific data manipulation or data forgery as a way to make science more decentralized and anti-fragile, without losing data integrity or reputation as a trade-off. The authors address it by proposing an online research platform for use in social and behavioral science that guarantees data integrity through a combination of modern institutional economics and blockchain technology.

Findings
The benefits are mainly twofold: On the one hand, social science scholars get paired with the right target audience for their studies. On the other hand, a snapshot of the gathered data at the time of creation is taken so that researchers can prove that they used the original data set to peers in the future while maintaining full control of their data.

Originality/value
The proposed combination of behavioral economics with new technologies such as blockchain and AI is novel and translated into a cutting-edge tool to be implemented.
Legal syncretism or the theory of unity in diversity as an alternative to legal pluralism in Indonesia
Authors: Isra Saldi , Tegnan Hilaire 
Published: August 2021

Purpose
Legal syncretism seeks to provide a rather different account of how laws interact with one another as the people deal with them. The purpose of this study is to provide a rather different account of how laws interact with one another as the people deal with them in the society.

Design/methodology/approach
This paper discusses the current concept of legal pluralism as to whether it really holds as the right theory for building a harmonious and trustworthy legal system in a multi-cultural country such as Indonesia. This study involves socio-legal research drawing on empirical data. It discusses the practice of legal pluralism in Indonesia by analyzing the characteristics of her legal system, especially the roles of customs and religion in it.

Findings
The research, conducted in five Indonesian cities, reveals that the current proposal of legal pluralism is not really helping to solve the difficulties faced by the Indonesian legal system. Therefore, this paper proposes legal syncretism or the theory of unity in diversity (bhineka tunggal ika) as an alternative to help cope with some of the difficulties faced by many legal systems in developing countries, especially Indonesia.

Originality/value
Although legal pluralism sounds promising, wrong and misleading interpretations have been provided by many of its proponents. Legal pluralism has been touted by many socio-legal scholars as a key concept in the analysis of law. Yet, after almost 20 years of such claims, there has been little progress in the development of the concept. Despite these confident pronouncements and the apparent unanimity that underlie them, however, the concept gives rise to complex unresolved problems. Legal syncretism seeks to provide a rather different account of how laws interact with one another as the people deal with them.
Consumer collecting identity and behaviors: underlying motivations and impact on life satisfaction
Authors: Spaid Brian , Matthes Joseph 
Published: August 2021

PurposeThe purpose of this paper is to understand the role that collector identity salience and collecting behaviors have on life satisfaction. The authors also investigate the role that dispositional motivations play in strengthening an individual’s collector identity salience.Design/methodology/approachAn online panel management system was used to recruit and compensate a diverse sample of 215 US consumer collectors. The structural model was tested with partial least squares structural equation modeling.FindingsA partial least squares structural equation model of data collected from a survey of US consumer collectors reveals that creative choice counter conformity and mortality legacy positively enhance collector identity salience, whereas materialism has no effect. Despite not affecting collector identity salience, materialism is found to negatively affect life satisfaction. Crucially, collector identity salience is found to positively affect collector engagement, which, in turn, enhances life satisfaction.Originality/valueThis research contributes to consumer behavior literature in three distinct ways. First, the authors build upon extant literature which has revealed creative choice counter conformity and mortality legacy as underlying dispositional motivations that contribute to collector identity salience. Second, while materialism has been tied to collecting behaviors via conceptual studies, the authors also examine the broader impact of materialism on an individual’s life satisfaction. Finally, the authors explore how collector identity salience and collector engagement contribute to satisfaction with life.
Determinants of online shopping attitudes of households in Turkey
Authors: Çebi Karaaslan Kübranur 
Published: August 2021

Purpose
Online shopping is expected to continue without slowing down because of the advantages that it presents to consumers in the digitalising world. This study aims to determine the factors regarding the social and environmental indicators and the demographical and economical factors that affect the online shopping tendencies of households in Turkey. The results of this research can be used to review the online shopping strategies by the decision-makers.

Design/methodology/approach
In this study, the cross-sectional data acquired from the Household Budget Research survey, which has been conducted by the Turkish Statistical Institute between 2015 and 2018, is used. In this data set consisting of 11,491 in 2015, 12,096 in 2016, 12,166 in 2017 and 11,828 in 2018, a total of 47,581 data from the households that are 15-year-old and older are used. To determine the factors affecting the online shopping behaviour of households, binary logistic regression and binary probit regression analyses are applied. As a result of these analyses, it has been decided that the most suitable model is the binary probit regression model.

Findings
According to the analysis results, it has been detected that factors such as educational status, age, marital status, employment status, income, life assurance ownership, credit card usage, automobile ownership and the year of the survey affect the online shopping behaviour of households.

Practical implications
In this study, factors affecting the tendency to do online shopping, which has gained big importance particularly with the COVID-19 pandemic, are determined. In Turkey, households’ tendency to do online shopping is affected by the demographical and economical factors and by the factors related to the social and environmental indicators. Determination of the effects of these factors has been a guide for the decision-makers and policymakers in explaining the tendency to shop online and creating a competitive advantage.

Originality/value
In this study, data consisting of a total of 47,581 observations, which has acquired from the Household Budget Research survey conducted by the Turkish Statistical Institute between 2015 and 2018, are used by applying a weighting process, and no study that is as comprehensive and inclusive as this study has been found in the literature, e-commerce that has become prevalent with the help of technological progress and changing habits in the past years is continuing to become prevalent more increasingly particularly after COVID-19 pandemic. Therefore, the value of this study underlies its contribution to e-commerce awareness.
Modeling collaborative consumption by extending self-determination theory: an emerging economy perspective
Authors: Garg Aashish , Sachdeva Muskan , Singh Simarjeet , Goel Pooja 
Published: August 2021

PurposeThis paper aims to cognizance consumers' intention to participate in collaborative consumption (CC). Also, the gender difference regarding the above is examined.Design/methodology/approachTo quantify the consumers’ intention to participate in CC cross-sectional survey method has been used. In total, 333 potential consumers selected through convenience sampling participated in the survey. The study used the capabilities of the structured equation modelling technique to validate the proposed research model.FindingsExcept for hedonic motives, all other drivers such as reputation, economic benefits, sustainable motives and trust have a significant influence on the intention to participate in CC. The effect of gender was found on the relationship between Trust and Intentions only.Practical implicationsThis study can be used as a guiding path in the domain of CC for practitioners, marketers, startups and policymakers as the opinion of potential users has been reported. The results of the study highlight that the consumers’ interest in CC participation and social reputation are the most influential drivers of intention to participate in CC. Marketers should design their strategies in such a way that the individual should feel like a social hero rather than just a responsible consumer while participating in CC.Originality/valueThe present study contributes to the literature by examining the intention to participate in CC through the lens of self-determination theory (SDT), specifically in the Indian context. The authors have also extended the SDT by adding a trust factor that is best to their knowledge not integrated till now. The present study integrated cognitive, economic, psychological and relational aspects to understand CC behavior.
Clinical characteristics and treatment status of pustulotic arthro‐osteitis: A single‐center study involving 51 cases
Authors: Kondo Naoki , Sakai Yohei , Kakutani Rika , Netsu Takahiro , Kijima Yasufumi , Kudo Naoko , Endo Naoto , Kawashima Hiroyuki 
Published: August 2021

AbstractPustulotic arthro‐osteitis (PAO) is a major complication of palmoplantar pustulosis (PPP). In orthopedic surgery outpatient clinics, PPP patients with osteoarticular symptoms are seen frequently, but PAO's clinical features remain not well known. To determine Japanese patients’ clinical features and treatment status with PAO, we conducted a single‐center retrospective epidemiologic survey. Clinical features, including gender, age, smoking habit, the onset pattern, interval between skin manifestation and osteoarticular symptoms, and the incidence of sternoclavicular joint lesions, axial and peripheral joint lesions, were examined. The association between physical status and image findings by X‐ray, computed tomography, bone scintigraphy with Technetium99, or magnetic resonance imaging was evaluated. The distribution pattern of peripheral joint lesions and the treatment status were evaluated.We identified 51 patients, 10 men and 41 women, with PAO. The average age was 48 years and 59% were smokers. The frequency of onset patterns was skin‐leading type (63%), simultaneous onset (18%), and osteoarticular leading type (16%). The average interval between skin involvement and osteoarticular involvement in skin‐leading type was significantly longer than that in osteoarticular leading type (7.1 years vs. 2.0 years).A sternoclavicular joint (SCJ) lesion was detected in 65% cases, and the physical findings of SCJ were significantly related to the image findings. Axial and peripheral joint lesions were detected in the same ratio (23 cases, 45%). In the peripheral joints, the finger joint was the most common (26%), followed by the shoulder joint (21%). Patients were treated with nonsteroidal anti‐inflammatory drugs (76%), followed by conventional synthetic disease‐modifying antirheumatic drugs (DMARDs) (29%) and biological DMARDs (9.8%). Tonsillectomy was performed in 11 cases. In conclusion, PAO more frequently involves SCJ in middle‐aged women who smoke. Given that osteoarticular leading type was detected in 16% cases, seronegative oligoarthritis patients should be monitored for PPP, leading to a diagnosis of PAO.
Granulocyte and monocyte adsorptive apheresis for pyoderma gangrenosum
Authors: Higashi Yuko , Ibusuki Atsuko , Baba Naoko , Hatanaka Miho , Tada Ko‐Ichi , Kanekura Takuro 
Published: August 2021

AbstractPyoderma gangrenosum (PG), a chronic aseptic inflammatory skin disease characterized by skin ulcers with elevated and undermined borders, is resistant to conventional therapies. PG is elicited by activated neutrophils and macrophages and is often associated with systemic diseases such as inflammatory bowel disease, rheumatoid arthritis, aortitis syndrome, and hematopoietic disorders. This single‐center study assessed the efficacy and safety of selectively depleting myeloid‐lineage leukocytes in patients with PG. Patients with PG, aged 20 or over, received 5 or 10 treatment sessions of granulocyte and monocyte adsorption apheresis (GMA), once or twice a week. Treatment efficacy was assessed based on the rate of skin ulcer reduction, the visual analog scale of pain, and the physician's global assessment of the skin lesions. A complete response (CR) was obtained in eight patients, a nearly complete response (nCR) in three patients, and a partial response (PR) in two patients. In four of the other six, the disease remained stable (SD) and in two we observed disease progression (PD). No severe adverse events were recorded. Our results suggest that GMA is a useful and safe treatment modality for PG.