bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Value and Function of HOXB5 in Acute Myeloid Leukemia
Authors: Chen Miao , Qu Yi , Yue Pengjie , Yan Xiaojing 
Published: August 2021

BackgroundCurrently, cytogenetic and genetic markers are the most important for risk stratification and treatment of patients with acute myeloid leukemia (AML). Despite the identification of many prognostic factors, relatively few have made their way into clinical practice. Therefore, the identification of new AML biomarkers is useful in the prognosis and monitoring of AML and contributes to a better understanding of the molecular basis of the disease. Homeobox (HOX) genes are transcription factors that lead to cell differentiation blockade and malignant self-renewal. However, the roles of HOX genes in AML are still not fully understood and need further exploration, which may provide new strategies for the prognosis and monitoring of AML.MethodsWe analyzed the RNA sequencing and clinical data from The Cancer Genome Atlas (TCGA), VIZOME, GSE13159, and GSE9476 cohorts. Analyses were performed with GraphPad 7, the R language, and several online databases. We applied quantitative polymerase chain reaction, Western Blotting, CCK8 cell proliferation assays, and flow cytometry to verify the conclusions of the bioinformatics analysis.ResultsWe identified HOXB5 as the only gene among the HOX family that was not only elevated in AML but also a significant prognostic marker in AML patients. HOXB5 was highly expressed in AML patients with NPM1, FLT3, or DNMT3A mutations and was expressed at the highest level in patients with NPM1-FLT3-DNMT3A triple-mutant AML. Gene Ontology analysis and gene set enrichment analysis revealed that HOXB5 showed a negative correlation with the myeloid cell differentiation signature and that the tumor necrosis factor/nuclear factor κB signaling pathway was involved in the molecular mechanism. Moreover, we performed in silico protein–protein interaction analysis and 450K TCGA DNA methylation data analysis and found that HOXB5 interacted with two HOX genes (HOXA7 and HOXB4) that were commonly regulated by DNA methylation levels.ConclusionHOXB5 is associated with the malignant development of AML and may be a treatment target and biomarker for AML prognosis prediction.
Sensitivities of Porous Beds and Plates to Ignition by Firebrands
Authors: Bean Derek , Blunck David L. 
Published: August 2021

The increasing occurrence of severe wildfires, coupled with the expansion of the wildland urban interface has increased the number of structures in danger of being destroyed by wildfires. Ignition by firebrands is a significant avenue for fire spread and structure loss; thus, understanding processes and parameters that control the ignition of fuel beds by firebrands is important for reducing these losses. In this study the effect of fuel bed characteristics (i.e., particle size and porous or solid fuel bed) on ignition behavior was considered. Modelling and analysis was conducted to better understand parameters that are dominant in controlling ignition. The fuel beds, made from Douglas-fir shavings, Douglas-fir plates, or cardboard plates, were heated with a cartridge heater (i.e., surrogate firebrand) to observe ignition. Smaller particles were observed to ignite more readily in porous beds than larger particles when heat transfer from the heater is primarily through conduction. This occurs in large part due to differences in contact area between the fuel bed and the heater coupled with thermal properties of the fuel bed. As particle sizes increased, ignition was more likely to occur at extended times (&gt;100 s) due to the increased importance of radiation heat transfer. Douglas-fir plates were primarily observed to ignite at times where conduction was the dominant mode of heat transfer (&lt;10 s). Heat flux delivered to the fuel bed was observed to be a more accurate predictor of ignition likelihood and ignition time than heater temperatures. The characteristic ratio of transport and chemical timescales can be used, in conjunction with the measured heat flux and thermal diffusivity of the fuel beds, as a first approximation to predict ignition for the porous fuel beds. This suggests that future work focusing on these parameters may produce a general characterization of fuel bed ignition probability across fuel beds materials and morphologies.
An Epidemiological Meta-Analysis on the Worldwide Prevalence, Resistance, and Outcomes of Spontaneous Bacterial Peritonitis in Cirrhosis
Authors: Tay Phoebe Wen Lin , Xiao Jieling , Tan Darren Jun Hao , Ng Cheng , Lye Yan Nerng , Lim Wen Hui , Teo Vanessa Xin Yi , Heng Ryan Rui Yang , Yeow Marcus Wei Xuan , Lum Lionel Hon Wai , Tan Eunice Xiang Xuan , Kew Guan Sen , Lee Guan Huei , Muthiah Mark D. 
Published: August 2021

Background and Aims: Spontaneous bacterial peritonitis (SBP) is a common and potentially fatal complication of liver cirrhosis. This study aims to analyze the prevalence of SBP among liver cirrhotic patients according to geographical location and income level, and risk factors and outcomes of SBP.Methods: A systematic search for articles describing prevalence, risk factors and outcomes of SBP was conducted. A single-arm meta-analysis was performed using generalized linear mix model (GLMM) with Clopper-Pearson intervals.Results: Ninety-Nine articles, comprising a total of 5,861,142 individuals with cirrhosis were included. Pooled prevalence of SBP was found to be 17.12% globally (CI: 13.63–21.30%), highest in Africa (68.20%; CI: 12.17–97.08%), and lowest in North America (10.81%; CI: 5.32–20.73%). Prevalence of community-acquired SBP was 6.05% (CI: 4.32–8.40%), and 11.11% (CI: 5.84–20.11%,) for healthcare-associated SBP. Antibiotic-resistant microorganisms were found in 11.77% (CI: 7.63–17.73%) of SBP patients. Of which, methicillin-resistant Staphylococcus aureus was most common (6.23%; CI: 3.83–9.97%), followed by extended-spectrum beta-lactamase producing organisms (6.19%; CI: 3.32–11.26%), and lastly vancomycin-resistant enterococci (1.91%; CI: 0.41–8.46%). Subgroup analysis comparing prevalence, antibiotic resistance, and outcomes between income groups was conducted to explore a link between socioeconomic status and SBP, which revealed decreased risk of SBP and negative outcomes in high-income countries.Conclusion: SBP remains a frequent complication of liver cirrhosis worldwide. The drawn link between income level and SBP in liver cirrhosis may enable further insight on actions necessary to tackle the disease on a global scale.
Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion Management
Authors: Carrick Frederick R. , Pagnacco Guido , Azzolino Sergio F. , Hunfalvay Melissa , Oggero Elena , Frizzell Tory , Smith Christopher J. , Pawlowski Gabriela , Campbell Natasha K. J. , Fickling Shaun D. , Lakhani Bimal , D’Arcy Ryan C. N. 
Published: August 2021

Background:Prior concussion studies have shown that objective neurophysiological measures are sensitive to detecting concussive and subconcussive impairments in youth ice-hockey. These studies monitored brain vital signs at rink-side using a within-subjects design to demonstrate significant changes from pre-season baseline scans. However, practical clinical implementation must overcome inherent challenges related to any dependence on a baseline. This requires establishing the start of normative reference data sets.Methods:The current study collected specific reference data forN= 58 elite, youth, male ice-hockey players and compared these with a general reference dataset fromN= 135 of males and females across the lifespan. The elite hockey players were recruited to a select training camp through CAA Hockey, a management agency for players drafted to leagues such as the National Hockey League (NHL). The statistical analysis included a test-retest comparison to establish reliability, and a multivariate analysis of covariance to evaluate differences in brain vital signs between groups with age as a covariate.Findings:Test-retest assessments for brain vital signs evoked potentials showed moderate-to-good reliability (Cronbach’s Alpha &gt; 0.7, Intraclass correlation coefficient &gt; 0.5) in five out of six measures. The multivariate analysis of covariance showed no overall effect for group (p= 0.105), and a significant effect of age as a covariate was observed (p&lt; 0.001). Adjusting for the effect of age, a significant difference was observed in the measure of N100 latency (p= 0.022) between elite hockey players and the heterogeneous control group.Interpretation:The findings support the concept that normative physiological data can be used in brain vital signs evaluation in athletes, and should additionally be stratified for age, skill level, and experience. These can be combined with general norms and/or individual baseline assessments where appropriate and/or possible. The current results allow for brain vital sign evaluation independent of baseline assessment, therefore enabling objective neurophysiological evaluation of concussion management and cognitive performance optimization in ice-hockey.
Abnormal Functional Connectivity Between the Left Medial Superior Frontal Gyrus and Amygdala Underlying Abnormal Emotion and Premature Ejaculation: A Resting State fMRI Study
Authors: Xu Yan , Zhang Xing , Xiang Ziliang , Wang Qing , Huang Xinfei , Liu Tao , Yang Zhaoxu , Chen Yun , Xue Jianguo , Chen Jianhuai , Yang Jie 
Published: August 2021

IntroductionPremature ejaculation (PE) is a common sexual dysfunction and is found to be associated with abnormal emotion. The amygdala plays an important role in the processing of emotion. The process of ejaculation is found to be mediated by the frontal-limbic neural circuits. However, the correlations between PE and emotion are still unclear.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) data were acquired in 27 PE patients with stable emotion (SPE), 27 PE patients with abnormal emotion (NPE), and 30 healthy controls (HC). We used rs-fMRI to explore the underlying neural mechanisms in SPE, NPE, and HC by measuring the functional connectivity (FC). Differences of FC values among the three groups were compared when choosing bilateral amygdala as the regions of interest (ROIs). We also explored the correlations between the brain regions showing altered FC values and scores of the premature ejaculation diagnostic tool (PEDT)/Eysenck Personality Inventory about neuroticism (EPQ-N) in the PE group.ResultsWhen the left amygdala was chosen as the ROI, the SPE group exhibited an increased FC between the left medial superior frontal gyrus (SFGmed) and amygdala compared with the NPE or HC group. When the right amygdala was chosen as the ROI, the NPE group exhibited a decreased FC between the left SFGmed and right amygdala compared with the HC group. In addition, FC values of the left SFGmed had positive correlations with PEDT and negative correlations with EPQ-N scores in the PE group. Moreover, FC values of the left superior temporal gyrus had positive correlations with EPQ-N scores in the PE group.ConclusionThe increased FC values between the left SFGmed and amygdala could reflect a compensatory cortical control mechanism with the effect of stabilized emotion in the limbic regions of PE patients. Abnormal FC between these brain regions could play a critical role in the physiopathology of PE and could help us in dividing PE into more subtypes.
Association Between Preoperative Factors and In-hospital Mortality in Neonates After Cardiac Surgery in China
Authors: Hu Renjie , Zhu Hongbin , Qiu Lisheng , Hong Haifa , Xu Zhiwei , Zhang Haibo , Chen Hao 
Published: August 2021

Background: Little is known about preoperative factors affecting cardiac surgery outcomes of neonates in China. We sought to examine the association between characteristics of neonates with congenital heart disease (CHD) and early postoperative outcomes after cardiac repair in a tertiary care paediatric hospital.Methods: A single-centre retrospective cohort study of neonates who underwent cardiac surgery between January 2006 and December 2019 was performed. Demographic, institutional, and surgical characteristics of neonates were examined and their association with in-hospital mortality was analysed using multivariable logistic regression models.Results: During the study period, we analysed the outcomes of 1,078 neonates. In-hospital mortality decreased to 13.8% in the era 2017–2019. The overall in-hospital mortality rate was 16.3%. Normal weight at surgery [odds ratio (OR), 0.63; 95% confidence interval (CI), 0.47–0.85; P = 0.003] was associated with lower mortality risk. Poor health status (emergent: OR, 3.11; 95% CI, 1.96–4.94; P &lt; 0.001; elective: OR, 1.63; 95% CI, 1.11–2.40; P = 0.013), higher Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) categories (STAT 5 category: OR, 2.58; 95% CI, 1.04–6.43; P = 0.042), and limited individual surgeon experience (surgeon with 5–10 operations per year: OR, 1.43; 95% CI, 1.06–1.95; P = 0.021) were associated with higher odds of early death.Conclusion: In-hospital mortality after neonatal cardiac surgery remained high in our centre over the past 10 years. Some preoperative aspects, including low-weight at surgery, poor health status, increased surgical complexity, and limited surgeon experience were significantly associated with higher mortality. Based on the observed associations, the necessary practises to be modified, especially in preoperative care, should be identified and assessed in future research.
A Novel Thoracic Ultrasound Measurement After Congenital Diaphragmatic Hernia Repair Identifies Decreased Diaphragmatic Excursion Associated With Adverse Respiratory and Surgical Outcomes
Authors: Ross James T. , Liang Norah E. , Phelps Andrew S. , Squillaro Anthony I. , Vu Lan T. 
Published: August 2021

Background and Aim: Congenital diaphragmatic hernia (CDH) is a rare defect often associated with pulmonary hypoplasia and abnormal pulmonary vascular development. Even after successful hernia repair, pulmonary disease may persist into adulthood. Impaired diaphragmatic motility may lead to compromised respiratory function long after index repair. This study investigates whether a novel ultrasound measurement, the diaphragmatic excursion ratio, can be a simple and non-invasive method to evaluate routine diaphragmatic motion after CDH repair, and whether it correlates with adverse surgical and respiratory outcomes.Materials and Methods: A cross-sectional study was conducted in consecutive patients who presented at medium-term follow-up visit between December 2017 and December 2018 after CDH repair at single pediatric hospital. Transthoracic ultrasound was performed with craniocaudal diaphragmatic excursion measured bilaterally during routine breathing. Diaphragmatic excursion ratios (diaphragmatic excursion of repaired vs. unrepaired side) were calculated and retrospectively compared with clinical data including demographics, length of stay, respiratory adjuncts, oral feeding, and need for gastrostomy.Results: Thirty-eight patients (median age at ultrasound, 24 months, interquartile range 11–60) were evaluated. Nine patients underwent primary repair, 29 had non-primary repair (internal oblique muscle flap or mesh patch). Patients with a diaphragmatic excursion ratio below the median (0.54) had longer hospital stays (median 77 vs. 28 days, p = 0.0007) more ventilator days (median 16 vs. 9 days, p =0.004), and were more likely to have been discharged on oxygen (68 vs. 16%, p = 0.001). They were also less likely to be exclusively taking oral feeds at 1-year post-surgery (37 vs. 74%, p = 0.02) and more likely to require a gastrostomy tube in the first year of life (74 vs. 21%, p = 0.003).Conclusions: Transthoracic ultrasound after CDH repair is practical method to assess diaphragm motion, and decreased diaphragm excursion ratio is associated with worse respiratory outcomes, a longer length of stay, and dependence on gastrostomy tube feeding within 1 year. Further prospective studies may help validate this novel ultrasound measurement and offer prognostic value.
Targeting Soluble Epoxide Hydrolase and Cyclooxygenases Enhance Joint Pain Control, Stimulate Collagen Synthesis, and Protect Chondrocytes From Cytokine-Induced Apoptosis
Authors: Tucker Laura , Trumble Troy N. , Groschen Donna , Dobbs Erica , Baldo Caroline F. , Wendt-Hornickle Erin , Guedes Alonso G. P. 
Published: August 2021

Objective:To determine the symptomatic and disease-modifying capabilities of sEH and COX inhibitors during joint inflammation.Methods:Using a blinded, randomized, crossover experimental design, 6 adult healthy horses were injected with lipopolysaccharide (LPS; 3 μg) fromE. coliin a radiocarpal joint and concurrently received the non-selective cyclooxygenase (COX) inhibitor phenylbutazone (2 mg/kg), the sEH inhibitort-TUCB (1 mg/kg) or both (2 mg/kg phenylbutazone and 0.1, 0.3, and 1 mg/kgt-TUCB) intravenously. There were at least 30 days washout between treatments. Joint pain (assessedviainertial sensors and peak vertical forces), synovial fluid concentrations of prostanoids (PGE2, TxB2), cytokines (IL-1β, IL-6, TNF-α) and biomarkers of collagen synthesis (CPII) and degradation (C2C) were measured at pre-determined intervals over a 48-h period. The anti-apoptotic effect of COX and sEH inhibitors was determinedviaELISA technique in primary equine chondrocytes incubated with TNF-α (10 ng/ml) for 24 h. Apoptosis was also determined in chondrocytes incubated with sEH-generated metabolites.Results:Combined COX and sEH inhibition produced significantly better control of joint pain, prostanoid responses, and collagen synthesis-degradation balance compared to each compound separately. When administered separately, pain control was superior with COXvs. sEH inhibition. Cytokine responses were not different during COX and/or sEH inhibition. In cultured chondrocytes, sEH inhibition alone or combined with COX inhibition, but not COX inhibition alone had significant anti-apoptotic effects. However, sEH-generated metabolites caused concentration-dependent apoptosis.Conclusions:Combined COX and sEH inhibition optimize pain control, attenuate loss of articular cartilage matrix during joint inflammation and cytokine-induced chondrocyte apoptosis.
Impacto de los derivados de la caña de azúcar sobre las propiedades físico-mecánicas del hormigón
Authors: Muñoz-Pérez Sócrates Pedro , Coronel-Camino Ramiro Stalin , Vargas Villafuerte Julio César 
Published: August 2021

El presente artículo tiene como objetivo evaluar el comportamiento físico mecánico del hormigón con productos derivados de la caña de azúcar tales como (1) la ceniza de bagazo de caña de azúcar (CBCA) como reemplazo porcentual y gradual del cemento; y (2) la fibra de bagazo de caña de azúcar (FBCA) como reemplazo porcentual respecto al peso del agregado. Se revisó 46 artículos científicos referidos al tema entre la base de datos SCOPUS y SciELO, cuyos resultados encontrados fueron que al incorporar entre el 20% al 30% de CBCA incinerada entre 600ºC y 800 ºC mejora sustancialmente la trabajabilidad, resistencia a la compresión y flexión; por otra parte la incorporación de FBCA tratada (lavada y sumergida en hidróxido de calcio) en porcentajes que van del 0.5% al 1.5% respecto al peso del agregado, mejora también las propiedades de resistencia principalmente.
Pendampingan Kelas Ibu Hamil Dimasa Pandemi Covid
Authors: Siti Cholifah  , Paramitha Amelia Kusumawardani  , Lely Ika Mariyati  , Syndy Syeny Yuana  
Published: August 2021

Upaya peningkatan derajat kesehatan Ibu hamil terus dilakukan, meningat masiht ingginya Angka kematian Ibu (AKI) di Indonesia, Di masa pandemic mengakibatkan berbagai permasalahan kesehatan termasuk kesehatan ibu hamil. Kebijakan pemerintah untuk menerapkan menjaga jarak sosial, menjaga jarak fisik dan bekerja dari rumah sebagai upaya untuk pencegahan penularan covid-19, menyebabkan kegiatan kelas ibu hamil tidak bisa dilaksanakan. Sehingga tujuan dari kelas ibu hamil sebagai salah satu upaya pemerintah untuk menurunkan angka kesakitan dan kematian ibu dan bayi melalui kelas ibu hamil yang merupakan bagian dari antenatal berkualitas tidak tedapat terlaksana. Permasalahan yang dihadapi oleh mitra berdasarkan hasil observasi dan dikusi antara lain kecemasan ibu hamil bersalin dimasa pandemi dan kurangnya pengetahuan tentang cara mengatasi stress selama kehamilan, kebutuhan senam hamil belum terpenuhi, kurangnya pemberdayaan ibu hamil untuk meningkatkan status kesehatan. Solusi permasalahan mitra dengan melakukan pendampingan kelas ibu hamil di masa pandemi. Program pengabdian masyarakat ini dilakukan pada tanggal 29 Desember 2020 sampai 12 Januari 2021 pada kelas ibu hamil desa Ketimang Kecamatan Wonoayu Kabupaten Sidoarjo. Metode yang dilakukan adalah pendampingan kelas ibu hamil, kegiatan pendidikan kesehatan dan pelatihan pada ibu hamil. Hasilnya ada peningkatan pengetahuan ibu hamil tentang manajemen stres, senam hamil dan akupresur untuk meningkatkan status kesehatan ibu hamil
Kecemasan Pegawai Perjanjian Kerja Waktu Tertentu (PKWT) terhadap Job Performance
Authors: Dian Bagus Mitreka Satata  
Published: August 2021

Work is the physical and mental process of an individual in achieving his goals, but uncertainty in the work will cause anxiety. Anxiety is a state of worry that complains that something bad will happen soon so that job performance becomes an indicator in continuing work in accordance with the applicable abilities and conditions. The subjects in this study were 36 contract employees in one of the regional secretariat agencies in Malang with a purposive sampling technique. Data were collected using the Hamilton Anxiety Rating Scale (HAM-A) instrument and the Individual Work Performance Scale (IWP). The results of the analysis show that there is no effect of anxiety on job performance, so that active PKWT employees can still carry out their work in accordance with the job descriptions and the provisions of the applicable work agreement without the pressure of anxiety.
Keywords: Anxiety, job performance, employment contract
Fintech Based Peer-too-peer (P2P) Lending : A Perspective of MSMEs In the New Normal Era of Pandemic Covid-19
Authors: Zakiyah Tuti 
Published: August 2021

The purpose of this research is to find out the role of Fintech Peer to Peer (P2P) lending based on the perception in the new normal era of Covid-19 as a financial inclusion for the recovery of the MSME financial sector. The population of this research is MSMEs in Central Java and East Java Provinces. The survey method was carried out by collecting data using a questionnaire as a data collection tool. In addition, researchers also use purposive sampling method to determine the sample. The analysis hypothesis is used the outer model and EViews 10 for the evaluation of the inner model. The results of this study are that peer to peer lending together has a significant effect on the interests of MSME actors in East Java in The New Normal Era of the Covid-19, this is also supported by the Adjevtive R value which shows the number 87%.