bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEITO ANTIOXIDANTE DO ÁCIDO LIPÓICO EM LESÕES CUTÂNEAS DE RATOS DIABETICOS INDUZIDOS POR ALOXANO
Authors: Sampaio Luis Rafael Leite , Feitosa Emanuel Messias Silva , Rodrigues Vithória Régia Teixeira , Sousa Francisca Clarisse de , Rolim Karla Maria Carneiro , Silva Cláudio Gleidiston Lima da 
Published: February 2021

Objetivo: averiguar os efeitos antioxidantes do ácido lipóico (ALA) no tratamento de lesões cutâneas em ratos diabéticos induzidos por aloxano. Método: Utilizou-se um teste experimental pré-clínico, constituído pelas seguintes etapas: Definição dos animais com as características necessárias para o experimento; indução do diabetes experimental; tricotomia e produção da ferida cutânea após confirmação do Diabetes Mellitus; protocolo de tratamento: G1 (grupo controle), G2 (100 mg/kg de ALA) e G3 (200mg/kg de ALA) durante 1, 7 ou 14 dias; análise do efeito antioxidante e finalmente a análise estatística dos dados coletados. Resultados: Através da análise estatística, observou-se que o ALA reduziu a concentração de malonildialdeido (MDA) e elevou a concentração de glutationa peroxidase (GSH) no tratamento agudo ou em doses repetidas por 7 ou 14 dias. Conclusão: O ALA é um dermoprotetor sistêmico capaz de tratar alterações causadas pelo aloxano nos parâmetros de MDA, de nitrito/nitrato e GSH em lesões de ratos.
Un avance contra la impunidad
Authors: Tojeira José M 
Published: February 2021

El auto de procesamiento del juez español de la Audiencia Nacional, Eloy Velasco, cuya lectura recomendamos, ha conmocionado a la sociedad salvadoreña. Nunca un grupo tan numeroso de miembros de la Fuerza Armada, y con una representación tan elevada de generales y coroneles, había sido llevado a juicio por delitos cometidos en la guerra civil de los ochenta. Más que el grito, la condena o el aplauso, lo importante es extraer lecciones que sirvan a todos los salvadoreños para construir un país reconciliado con su pasado, con reconciliación real entre sus propios conciudadanos y más unido en la construcción de un futuro sin violencia e impunidad ante el crimen. Para colaborar en esta tarea, desarrollamos una breve reflexión, que puede servir como marco para la lectura inteligente del auto de procesamiento del juez Velasco y para relacionarlo adecuadamente con nuestra propia realidad nacional. Dividimos el presente artículo en cuatro partes. Comenzamos con una somera descripción del marco histórico que enmarca y ayuda a comprender la apertura del juicio en España. Seguimos con un segundo apartado en el que evaluamos los aportes que el juez Velasco ofrece frente a la historia de impunidad del caso jesuitas, y pasamos a continuación al análisis del modo de proceder de la Corte Suprema ante la solicitud de cooperación con el caso abierto en España. Consideramos esta tercera parte de gran importancia, aunque en algunos aspectos parezca accidental o que roza superficialmente el caso, porque en realidad nos muestra a una Corte muy cerrada, con serias deficiencias jurídicas y con muy poca imaginación ante la problemática que ofrecen crímenes del pasado que la gran tendencia actual del derecho considera imprescriptibles. Terminamos el artículo mencionando superficialmente algunas posibilidades que ya han sido exploradas con mayor hondura en otras publicaciones y artículos. Convertir el limón en limonada siempre ha sido más inteligente que rechazar compulsivamente lo que nos desagrada o molesta. Ayudar a que leamos el auto de procesamiento del juez Velasco desde la necesidad de encontrar caminos de verdad, justicia y reconciliación sería el mejor premio para quien escribe estas líneas.
ECA Estudios Centroamericanos, Vol. 66, No. 725, 2011: 179-188.
FİRMA VE YÖNETİCİ ÖZELLİKLERİNE GÖRE İHRACAT PERFORMANS DÜZEYLERİNİN İNCELENMESİ: İSTANBUL İLİ İHRACATÇI FİRMALAR ÜZERİNE BİR ARAŞTIRMA
Authors: SAĞLAM Mehmet 
Published: February 2021

Uluslararası
pazarda başarılı olmayı amaçlayan firmaların, sahip oldukları yetkinlik, bilgi birikimi
ve tecrübelerini rekabet avantajı sağlama açısından kullanmaları önemlidir.
Bilgi çağına geçişle birlikte firmalar için önemi artan entelektüel sermaye
boyutlarından yapısal sermaye, insan sermayesi ve müşteri sermayesinin başarıya
ulaşmada payı büyük olacaktır.

Yapısal
sermaye açısından firma özelliklerinin, insan sermayesi açısından yönetici
özelliklerinin ele alındığı bu çalışmada ihracat performansının firma ve
yönetici özelliklerine göre farklılığı incelenmiştir. Kolayda örneklem
yöntemiyle ulaşılabilen İstanbul’daki 249 ihracatçı firma yöneticisi çalışmanın
örneklemini oluşturmaktadır. Veri analizinde SPSS 21 kullanılmıştır. Verilerin
normal dağılıma uyması sonucu farklılık testleri için Anova ve t testlerine yer
verilmiştir. Analiz sonucunda ihracat performans düzeylerinin firma büyüklüğü,
deneyimi ve faaliyet gösterilen sektör ile yönetici eğitim durumu, yönetici
kademesi ve yönetici deneyimine göre farklılaştığı belirlenmiştir.
Henrique Mindlin e seu escritório: a inserção da arquitetura na cadeia produtiva moderna
Authors: Sena Batista Antonio José de 
Published: February 2021

A historiografia da Arquitetura Moderna Brasileira tende a privilegiar a construção de uma coerência ficcional que determina grupos aos quais todos arquitetos atuantes naquele período são anexados. No entanto, uma análise mais detalhada traz à tona a existência de múltiplas formas de ação que não concorrem para tal unidade fictícia. Dentre elas estão os arquitetos que trabalham prioritariamente para o mercado da construção civil, que lhes impõe regras, meios, relações econômicas, que contaminam seu modo de operação projetual. Este artigo busca, através de uma breve análise da arquitetura do escritório Henrique Mindlin Arquitetos Associados, destacar certas características de concepção de projeto que os tornam distintos de outros escritórios atuantes no mesmo período e mostrar como sua arquitetura estabelece uma relação especifica com o espaço urbano.
A matemática da villa ideal
Authors: Rowe Colin 
Published: February 2021

A seção Arquivo neste número traz a tradução do clássico texto de Colin Rowe - The mathematics of the ideal Villa – publicado originalmente em Março de 1947 na revista Architectural Review, depois abre a coletânea de textos intitulada The mathematics of the ideal Villa and other essays, publicada pela MIT Press, em 1982, e, republicado em 1999, pela mesma MIT Press, em um dos três volumes que formam As I Was Saying: Recollections and Miscellaneous Essays, Collected essays, letters, and papers. O artigo talvez seja dos mais importantes documentos críticos publicados no século XX, cuja acurada comparação entre as ordens compositivas da Villa Malcontenda, de Palladio, e da Villa Garches, de Le Corbusier, estendeu os limites da reflexão acerca do objeto arquitetônico moderno logo após o término da Segunda Guerra Mundial. O direito de reprodução nos foi obtido junto ao MIT Press. A atualidade dos argumentos do texto original e a pertinência da tradução feita por Aurora Neiva, revisada de Rachel Coutinho M. da Silva, nos parece notória.
Ciclo 0-4: Concepção, criação, divulgação e consolidação (ou da Thésis à antithesis)
Authors: Amorim Luiz , Cotrim Marcio , Coutinho Rachel , Costa Xico 
Published: February 2021

Sem que houvesse consciência, o título do editorial da edição número 1 faz referência a ideia de ciclo – Da hipothésis à Thésis, ou seja, da concepção sobre como deveria e qual o papel do periódico de uma associação como a ANPARQ até a Thésis 4 que, orgulhosamente, entregamos agora aos leitores. Os quatro números são resultado de um profícuo processo de criação, divulgação e consolidação. Este é o último número sob nossa batuta. Trata-se, portanto, do encerramento de uma etapa inicial, que pretendeu ser coletivo em todos as instâncias da Associação e atender à diversidade e especificidade da nossa área.
Development of a MetUM (v 11.1) and NEMO (v 3.6) coupled operational forecast model for the Maritime Continent – Part 1: Evaluation of ocean forecasts
Authors: Thompson Bijoy , Sanchez Claudio , Heng Boon Chong Peter , Kumar Rajesh , Liu Jianyu , Huang Xiang-Yu , Tkalich Pavel 
Published: February 2021

Abstract. This article describes the development and ocean forecast
evaluation of an atmosphere–ocean coupled prediction system for the Maritime
Continent (MC) domain, which includes the eastern Indian and western Pacific
oceans. The coupled system comprises regional configurations of the
atmospheric model MetUM and ocean model NEMO at a uniform horizontal
resolution of 4.5 km × 4.5 km, coupled using the OASIS3-MCT libraries. The
coupled model is run as a pre-operational forecast system from 1 to 31 October 2019. Hindcast simulations performed for the period 1 January 2014
to 30 September 2019, using the stand-alone ocean configuration, provided
the initial condition to the coupled ocean model. This paper details the
evaluations of ocean-only model hindcast and 6 d
coupled ocean forecast
simulations. Direct comparison of sea surface temperature (SST) and sea
surface height (SSH) with analysis, as well as in situ observations, is
performed for the ocean-only hindcast evaluation. For the evaluation of
coupled ocean model, comparisons of ocean forecast for different forecast
lead times with SST analysis and in situ observations of SSH, temperature,
and salinity have been performed. Overall, the model forecast deviation of
SST, SSH, and subsurface temperature and salinity fields relative to
observation is within acceptable error limits of operational forecast
models. Typical runtimes of the daily forecast simulations are found to be
suitable for the operational forecast applications.
William Empson and C. S. Lewis: The Atonement
Authors: Rumrich John 
Published: February 2021

ABSTRACT
Literary critics, Milton scholars in particular, tend to register C. S. Lewis and William Empson as opposites on account of their sharply contrasting views about Christianity. Although Lewis had been an atheist as a young man, he converted to Christianity around 1930. Empson, too, may be said to have undergone an adult conversion around the same time—from the mere atheism of his youth to an increasingly strident anti-Christianity. His critical writings repeatedly describe belief in hell and atonement through Christ's sacrifice as sadistic. Lewis, for his part, enjoys widespread fame precisely for his popular writings in rational defense of Christian theology. Despite their indeed striking differences, there is more common ground between them as literary critics than is generally recognized, even when it comes to Christian theology and specifically the doctrine of the Atonement.
“Fittest to Choose”: Milton Against Celebrity
Authors: Harper David A. 
Published: February 2021

ABSTRACT
Milton was concerned with the dangers of populism throughout his career, most notably in Eikonoklastes and The Readie and Easie Way as he took on the celebrity king, Charles I. Sometimes charged with being an elitist who disregarded the common man, Milton actually worried about the political backwardness that populism engenders and the threat it poses not only to the political life of the nation, but also to the capacity for human salvation. His solution was a domestic “nation-building” grounded in educational reform. This article highlights the dangers Milton apprehended in the allure of fame and in the difficulties of preparing citizens to choose wisely when faced with the partisan allure of celebrity politicians.
Twenty Five–Year Publication Trends in Foot and Ankle Literature: Improved Methodological Quality and Internationality With Time
Authors: Klavas Derek M. , Liu Jonathan , Holderread Brendan M. , Ahuero Jason S. , Cosculluela Pedro E. , Varner Kevin E. , Harris Joshua D. 
Published: February 2021

Background:
Methodological quality and author internationality are increasing in orthopaedic surgery. The purpose of this study was to evaluate the methodological quality and author geography trends from 1994 to 2019 in high-quality foot and ankle journals.

Methods:
Analyses of 1,242 foot and ankle publications in Foot and Ankle International, American Journal of Bone and Joint Surgery, and American Journal of Sports Medicine were done for 1994, 1999, 2004, 2009, 2014, and 2019. Articles were classified according to study type, level of evidence (LOE), and author's country of publication.

Results:
The most common clinical study was therapeutic (65.4). Significant increases were noted in the proportion of therapeutic (P < 0.01) and prognostic (P < 0.01) articles. The average LOE increased from 3.96 ± 1.01 to 3.19 ± 0.97 (P < 0.01). The proportion of Level I (P = 0.29) and level IV articles (P = 0.21) remained constant, level II (P < 0.01) and level III (P < 0.01) articles increased, and level V (P < 0.01) articles decreased. United States authorship decreased from 78.1% in 1994 to 44.8% in 2009, then remained constant through 2019 (P < 0.01).

Conclusion:
This study demonstrated an improvement in LOE of foot and ankle publications across a 25-year period in three high-quality orthopaedic journals. Increasing internationality was also observed.
TRES LUPAS PARA EXAMINAR A PAU CASALS Y ANNE GASTINEL: ANÁLISIS DE LA AGÓGICA EN DOS INTERPRETACIONES DE LA SARABANDE BWV 1011 DE J.S. BACH.
Authors: Saenz Abarzuza Igor 
Published: February 2021

Pau Casals fue el primer violonchelista en grabar la integral de las Suites de Bach, siendo este uno de sus legados musicales más relevantes. Esta grabación concluida en 1939 y la realizada por Anne Gastinel en 2007, presentan una interesante similitud: la duración de la Sarabande de la Suite Nº5, BWV 1011, con una diferencia entre ambas inferior a los 3 segundos. A tenor de este escaso margen temporal, el objetivo del presente artículo es realizar mediciones de las duraciones a diferentes niveles o lupas en la Sarabande: las duraciones de cada grupo de 4 compases, las de cada compás y las de cada pulso, para posteriormente interpretar estos datos. Estas mediciones de la micro-agógica han sido efectuadas con el programa de análisis de audio Sonic Visualiser, y los datos obtenidos han sido analizados y comentados tanto por separado como en la comparación de ambos violonchelistas. Con todo ello, se muestran dos posibilidades distintas de ejecución de la agógica en unas grabaciones que, aunque en macro-agógica duran un tiempo similar, presentan sutiles convergencias y divergencias a medida que se agranda la lupa, dando cuenta del margen del intérprete en la ejecución.
La gestión directiva en la investigación del docente universitario en Lima
Authors: Madueño Ramos Percy 
Published: February 2021

ResumenEl objetivo general del estudio fue determinar la influencia de la gestión directiva en la investigación docente universitaria, en Lima Norte, en el año 2019. La investigación empleó el enfoque cuantitativo, el tipo de investigación fue básica, de nivel explicativo, con la aplicación del diseño no experimental, de corte transversal, para la prueba de hipótesis se utilizó la regresión logística interpretando los resultados del índice del pseudo R cuadrado de Nagelkerke y del nivel de significancia. La población estuvo conformada por 182 docentes universitarios del Programa de Estudios Generales, de una universidad privada societaria, de Lima, Perú, correspondiente al semestre académico 2019-2; y la muestra representativa fue de 124 docentes. Se aplicó la técnica de la encuesta y como instrumentos se utilizaron: la escala de evaluación de la gestión directiva y el cuestionario de investigación docente. Los instrumentos fueron sometidos a la validez de contenido a través del juicio de tres expertos con un resultado de aplicable y el valor de la confiabilidad fue con la prueba Alfa de Cronbach con coeficientes de 0,975 y 0,864 respectivamente, indicándonos una fuerte confiabilidad para ambos instrumentos. Los resultados de la investigación permitieron concluir que: existe influencia de la gestión directiva en la investigación docente universitaria, dado que el nivel de significancia resultó 0,000 y el Pseudo R cuadrado de Nagelkerke fue 0,708 equivalente a un 70,8% de influencia. Palabras claves: Gestión directiva, investigación docente, formación académica, motivación, publicación.
Evaluation of key miRNAs during early pregnancy in Kazakh horse using RNA sequencing
Authors: Liu LingLing , Fang Chao , Sun YinZe , Liu WuJun 
Published: February 2021

Background
miRNA has an important role in cell differentiation, biological development, and physiology. Milk production is an important quantitative trait in livestock and miRNA plays a role in the amount of milk produced.

Methods
The role of regulatory miRNAs involved in equine milk production is not fully understood. We constructed two miRNA libraries for Kazakh horse milk production from higher-producing (H group) and lower-producing (L group) individuals, and used RNA-Seq technology to identify the differentially expressed miRNAs between the two milk phenotypes of Kazakh horses.

Results
A total of 341 known and 333 novel miRNAs were detected from the H and L groups, respectively. Eighty-three differentially expressed miRNAs were identified between the H and L group s, of which 32 were known miRNAs (27 were up-regulated, five were down-regulated) and 51 were novel miRNAs (nine were up-regulated, 42 were down-regulated). A total of 2,415 genes were identified. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that these genes were annotated to mammary gland development, mammary gland morphogenesis, tissue development and PI3K-Akt signaling pathways, insulin signaling pathway and TGF-beta signaling pathway, among others. Five miRNAs (miR-199a-3p, miR143, miR145, miR221, miR486-5p) were identified as affecting horse milk production and these five miRNAs were validated using qRT-PCR.

Conclusions
We described a methodology for the transcriptome-wide profiling of miRNAs in milk, which may help the design of new intervention strategies to improve the milk yield of Kazakh horses.
A modularity analysis helps improving the structure of the International Code of Zoological Nomenclature
Authors: Vlachos Evangelos 
Published: February 2021

BackgroundIn a recent work I transformed a complex and integrated text like the International Code of Zoological Nomenclature into a network of interconnected parts of text. This new approach allowed understanding that a continuous body of text cannot accurately reflect the true structure of the Code, and provided a scientific methodology to identifya prioriparts that could be affected by future revisions. In this next step, I investigate further the structure of the Code, seeking to use the network in order to identify the various conceptual communities grouping the various articles and other text items of the Code.MethodsUsing the first version of the network of the Code, I perform a comprehensive modularity analysis in two rounds: the first round aims to identify the fewest and largest communities or modules for the entire network, whereas the second round identifies the sub-modules within each larger module. The potential conflicts between the current structure of the Code and the module composition are evaluated with a parcellation analysis.ResultsThe optimal modularity search identified 10 different modules in the entire network of varying size (ranging from 75 to 200 nodes). Each module can be further divided into smaller modules, that all-together allow describing the 65 conceptual groups of text items in the Code. Parcellation analysis revealed that two-thirds of the current chapters of the Code are in excellent or good accordance with the recovered conceptual modules, whereas the current composition of six chapters is in serious conflict with the conceptual structure of the Code.DiscussionJudging only the composition and not the order of appearance of the Articles in the Chapters of the Code, I show that in many cases the current structure of the Code is found to correspond quite well to the concepts presented therein. The most important conflict is found on the provisions related to the various groups of names governed by the Code: family-, genus-, and species-group names. Currently, these provisions are spread out in different Articles in different Chapters, along the entire length of the Code. The modularity analysis suggests that re-organizing the Code in chapters that will deal with all aspects related to a given group (e.g., chapters including information on name formation, availability, typification, and validity for a given group), could potentially improve reader experience and, consequently, the applicability of the Code.
Laparoscopic colposuspension for total vaginal prolapse
Authors: Ostrzenski A. 
Published: July 2002

AbstractObjective: To present and evaluate a new technique of modified translaparoscopic colpopexy for total vaginal prolapse following hysterectomy as an alternative surgical mode of therapy to abdominal sacral suspension or transvaginal sacrospinous ligament vaginal vault suspension. A modest modification (Group II) of this author's initial surgical technique (Group I) and postoperative observations from 1989 to 1996 are presented. Methods: Twenty‐seven patients with iatrogenic total vaginal prolapse subsequent to hysterectomy enrolled in this clinical study, which was conducted from September 1989 through February 1996. Posteriorly, vaginal apex was suspended to the deep layer of the uterosacral ligaments. The latero‐posteriors vaginal cuff was suspended to the cardinal ligaments. Anteriorly, the vaginal vault was approximated to the pubocervical fascia. These procedures were performed in both groups retroperitoneally. Additionally, and only in Group II, retrpubically, at the mid‐pelvic level, the pubocervical fascia and lateral superior vaginal sulci were suspended to the tendinous arch and to the fascia covering the muscles of the pelvic sidewall. This additional part of the operation constituted a modification of the initial translaparoscopic colpopexy (Group I). Results: In Group I, fifteen patients had good outcome of the operation. However, patient number 16 had a recurrent total vaginal vault prolapse within 6 months following the initial laparoscopic colpopexy. Preceding an initial laparoscopic colpopexy, sacrospinous ligament suspension was performed as one of multiple corrective surgeries. This patient was subjected to the modified laparoscopic colpopexy and has been observed for over three years. The vaginal vault remains well suspended in this particular case as well as in all remaining patients in Group II. There were neither intraoperative, immediate, nor delayed postoperative complications in all 27 patients, in both groups. Conclusions: (1) When Group I results are compared with Group II results, the new, modified translaparoscopic retroperitoneal‐retropubic colpopexy appeared to be a superior technique and very promising, and offers: (a) vaginal cuff suspension by using natural neighbouring genital pelvic structures, (b) reconstruction of pelvic gross/functional anatomy, placement of the vagina adequately in midline position, and alignment of the vagina parallel to the rectum, and re‐constitution of proper relationship between the newly suspended vagina and pelvic viscera. (2) It is a safe operation, simple to learn, and easy to execute; however, retroperitoneal‐retropubic‐mid‐pelvis surgical experience as well as advanced operative laparoscopic skill is needed to meet technical demands of the operation.