bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a sustainable development assessment framework to bridge supply chain practices and technologies
Authors: Centobelli Piera , Cerchione Roberto , Oropallo Eugenio , El‐Garaihy Wael Hassan , Farag Tamer , Al Shehri Khalid Hassan 
Published: November 2021

AbstractManaging sustainable practices has received increasing attention in the field of supply chain management to tackle environmental, financial and social issues in an integrated way. However, extant research still lacks a systemic framework explaining how sustainable practices can support individual companies to promote orchestration, collaboration, and coordination in the entire supply chain. This paper aims to provide a systemic framework including a taxonomy of sustainable development practices supporting individual firms in managing supply chain relationships. The proposed framework seeks to connect the supply chain practices and the technological systems that support them. Specifically, the findings highlight the relationship between technology capabilities and supply chain practices, focusing on the benefits their interaction brings to the complex dyadic relationships of supply networks. Finally, this study outlines promising future research directions for scholars and practitioners operating in the field of sustainable supply chain design and supply chain relationship management.
RCRdiff: A fully integrated Bayesian method for differential expression analysis using raw NanoString nCounter data
Authors: Xu Can , Wang Xinlei , Lim Johan , Xiao Guanghua , Xie Yang 
Published: November 2021

AbstractThe medium‐throughput mRNA abundance platform NanoString nCounter has gained great popularity in the past decade, due to its high sensitivity and technical reproducibility as well as remarkable applicability to ubiquitous formalin fixed paraffin embedded (FFPE) tissue samples. Based on RCRnorm developed for normalizing NanoString nCounter data and Bayesian LASSO for variable selection, we propose a fully integrated Bayesian method, called RCRdiff, to detect differentially expressed (DE) genes between different groups of tissue samples (eg, normal and cancer). Unlike existing methods that often require normalization performed beforehand, RCRdiff directly handles raw read counts and jointly models the behaviors of different types of internal controls along with DE and non‐DE gene patterns. Doing so would avoid efficiency loss caused by ignoring estimation uncertainty from the normalization step in a sequential approach and thus can offer more reliable statistical inference. We also propose clustering‐based strategies for DE gene selection, which do not require any external dataset and are free of any arbitrary cutoff. Empirical evidence of the attractiveness of RCRdiff is demonstrated via extensive simulation and data examples.
In Situ Electrochemical Activation Derived LixMoOy Nanorods as the Multifunctional Interlayer for Fast Kinetics Li‐S batteries
Authors: Li Tengyu , Li Yanan , Yang Jinlin , Deng Yirui , Wu Mengwei , Wang Qi , Liu Ruiping , Ge Ben , Xie Xiaokun , Ma Jianmin 
Published: November 2021

AbstractLi‐S batteries (LSBs) have attracted worldwide attention owing to their characteristics of high theoretical energy density and low cost. However, the commercial promotion of LSBs is hindered by the irreversible capacity decay and short cycling life caused by the shuttle effect of lithium‐polysulfides (LiPSs). Herein, a hybrid interlayer consisting of MoO3, conductive Ni foam, and Super P is prepared to prevent the shuttle effect and catalyze the LiPSs conversion. MoO3 with a reversible lithiation/delithiation behavior between Li0.042MoO3 and Li2MoO4 within 1.7–2.8 V versus Li/Li+ combines the Li+ insertion and LiPSs immobilization and efficiently improve the LSBs redox kinetics. Benefiting from the reversible Li+ insertion/extraction in lithium molybdate (LixMoOy) and the highly conductive Ni foam substrate, the sulfur cathode coupled with such electrochemical activation derived catalytic interlayer exhibits a high initial discharge capacity of 1100.1 mAh g−1 at a current density of 1 C with a low decay rate of 0.09% cycle−1. Good capacity retention can still be obtained even the areal sulfur loading is increased to 13.28 mg cm−2.
Temporospatial distribution and country of origin of canine transmissible venereal tumours in the UK
Authors: Gibson Danielle N. , Singleton David A. , Brant Beth , Radford Alan D. , Killick David R. 
Published: November 2021

AbstractBackgroundTransmissable venereal tumour (TVT) is a tumour transplanted by physical contact between dogs. Lesions typically affect the genitalia. TVT is not considered enzootic in the United Kingdom (UK), with cases seen in imported dogs. We sought to determine the patient characteristics, temporal and spatial distribution and country of origin of affected dogs in the UK.MethodsElectronic pathology records (EPRs) from four UK veterinary diagnostic laboratories collected between 2010 and 2019 were searched for the terms ‘venereal’ or ‘TVT’. Reports were reviewed for statements confirming a TVT and descriptive statistics collated.ResultsOf 182 EPRs matching the search terms, a diagnosis of TVT was confirmed in 71. Country of origin was noted in 36 cases (50.7%) with Romania being the most common (n = 29). Cases were reported in each UK constituent country, with the majority being in England (64, 90.1%). The incidence of TVT diagnosis increased over the last decade (z = 2.78, p = 0.005).ConclusionThe incidence of TVT diagnosed in the UK is increasing. The majority of cases were known to have been imported. Autochthonous transmission cannot be excluded due to study design. Vets are encouraged to carefully examine the genitalia of dogs imported to the UK from countries with enzootic TVT.
Pituitary dwarfism, patent duct arteriosus and Cushing's syndrome in a dog
Authors: Federica Alessandrini , Giovanni Romito , Federico Fracassi 
Published: November 2021

AbstractA 3‐month‐old, intact female Czechoslovakian wolfdog was referred for growth retardation. General physical examination revealed an IV/VI left basilar continuous murmur, a body condition score of 3/9, body weight 2.2 kg, and dermatological alterations. Transthoracic echocardiography diagnosed patent duct arteriosus. Genetic testing revealed that the dog had a LHX3 mutation, and the low concentration of insulin‐like growth factor 1 confirmed the diagnosis of pituitary dwarfism. The endocrine disorder was treated with levothyroxine, and the congenital heart disease was corrected interventionally, leading to a net improvement in the clinical condition. After 3 years, the dog was referred for polyuria, polydipsia, polyphagia and alopecia. Diagnostic workup revealed pituitary‐dependent hypercortisolism due to a pituitary macroadenoma. In addition to levothyroxine, the dog was treated with trilostane with resolution of the clinical signs.
Fat attenuating nasopharyngeal foreign body in an adult dog
Authors: Mukhina Anna , Zoto Alyssa , Cronin Kimberly , Cridge Harry 
Published: November 2021

AbstractA 10‐year‐old male neutered silky terrier presented for a 3‐day history of acute onset stertor and hyporexia. Physical examination revealed inspiratory and expiratory stertor, which resolved when the mouth was open and there was absent airflow through the right nostril. Computed tomography revealed a noncontrast‐enhancing fat attenuating structure (−33 Hounsfield units) occluding the right rostral nasopharyngeal lumen with a strong gas–fat interface rostrally and caudally. Anterior and retrograde rhinoscopy was performed. Retrograde rhinoscopy revealed the presence of brown/tan foreign material within the right nasopharynx, which was removed via flushing and manual retrieval. Anterior rhinoscopy was unremarkable. The foreign body was determined to be a pecan nut (∼72% fat), and removal resulted in resolution of clinical signs. This case report demonstrates the clinical utility of computed tomography in identifying the material of origin of unusual foreign bodies utilising Hounsfield units.
Presumptive and reversible left ventricular systolic dysfunction secondary to chloramphenicol administration in a dog
Authors: Hoff Sarah E. , Masters Allison K. , Tropf Melissa A. , Noxon James O. , Berger Darren J. 
Published: November 2021

AbstractA 6‐year‐old neutered male 35 kg Staffordshire terrier dog was presented for evaluation of interdigital furunculosis. Culture from lesions revealed meticillin‐resistant Staphylococcus pseudintermedius, with susceptibility to only amikacin, chloramphenicol and vancomycin. Chloramphenicol was administered at a dose of 1500 mg orally every 8 hours (42 mg/kg) for a total of 52 days. On Day 52 of treatment, a new mid‐systolic click was appreciated on cardiothoracic auscultation that prompted cardiac evaluation. Echocardiogram revealed mild mitral valve prolapse with no mitral valve regurgitation and mild left ventricular systolic dysfunction in multiple indices. Chloramphenicol was discontinued, and a recheck echocardiogram performed 63 days later showed persistent mild mitral valve prolapse and resolution of the left ventricular systolic dysfunction. Reversible left ventricular systolic dysfunction should be considered a potential complication associated with chloramphenicol therapy, and suggests chloramphenicol may need to be used with caution in canine patients with underlying cardiac disease.
Anticipating sea‐level rise and human migration: A review of empirical evidence and avenues for future research
Authors: Duijndam Sem J. , Botzen Wouter J. W. , Hagedoorn Liselotte C. , Aerts Jeroen C. J. H. 
Published: November 2021

AbstractSea‐level rise (SLR) threatens millions of people living in coastal areas through permanent inundation and other SLR‐related hazards. Migration is one way for people to adapt to these coastal changes, but presents an enormous policy challenge given the number of people affected. Knowledge about the relationship between SLR‐related hazards and migration is therefore important to allow for anticipatory policymaking. In recent years, an increasing number of empirical studies have investigated, using survey or census data, how SLR‐related hazards including flooding, salinization, and erosion together with non‐environmental factors influence migration behavior. In this article, we provide a systematic literature review of this empirical work. Our review findings indicate that flooding is not necessarily associated with increased migration. Severe flood events even tend to decrease long‐term migration in developing countries, although more research is needed to better understand the underpinnings of this finding. Salinization and erosion do generally lead to migration, but the number of studies is sparse. Several non‐environmental factors including wealth and place attachment influence migration alongside SLR‐related hazards. Based on the review, we propose a research agenda by outlining knowledge gaps and promising avenues for future research on this topic. Promising research avenues include using behavioral experiments to investigate migration behavior under future SLR scenarios, studying migration among other adaptation strategies, and complementing empirical research with dynamic migration modeling. We conclude that more empirical research on the SLR‐migration nexus is needed to properly understand and anticipate the complex dynamics of migration under SLR, and to design adequate policy responses.This article is categorized under:
Climate Economics < Aggregation Techniques for Impacts and Mitigation Costs
Vulnerability and Adaptation to Climate Change < Learning from Cases and Analogies
Assessing Impacts of Climate Change < Evaluating Future Impacts of Climate Change
Quantum kinetic equation for fluids of spin-1/2 fermions
Authors: Dayi Ömer F. , Kilinçarslan Eda 
Published: November 2021

Abstract
Fluid of spin-1/2 fermions is represented by a complex scalar field and a four-vector field coupled both to the scalar and the Dirac fields. We present the underlying action and show that the resulting equations of motion are identical to the (hydrodynamic) Euler equations in the presence of Coriolis force. As a consequence of the gauge invariances of this action we established the quantum kinetic equation which takes account of noninertial properties of the fluid in the presence of electromagnetic fields. The equations of the field components of Wigner function in Clifford algebra basis are employed to construct new semiclassical covariant kinetic equations of the vector and axial-vector field components for massless as well as massive fermions. Nonrelativistic limit of the chiral kinetic equation is studied and shown that it generates a novel three-dimensional transport theory which does not depend on spatial variables explicitly and possesses a Coriolis force term. We demonstrated that the three-dimensional chiral transport equations are consistent with the chiral anomaly. For massive fermions the three-dimensional kinetic transport theory generated by the new covariant kinetic equations is established in small mass limit. It possesses the Coriolis force and the massless limit can be obtained directly.
Scattering amplitudes for binary systems beyond GR
Authors: González Mariana Carrillo , de Rham Claudia , Tolley Andrew J. 
Published: November 2021

Abstract
Amplitude methods have proven to be a promising technique to perform Post-Minkowskian calculations used as inputs to construct gravitational waveforms. In this paper, we show how these methods can be extended beyond the standard calculations in General Relativity with a minimal coupling to matter. As proof of principle, we consider spinless particles conformally coupled to a gravitational helicity-0 mode. We clarify the subtleties in the matching procedure that lead to the potential for conformally coupled matter. We show that in the probe particle limit, we can reproduce well known results for the field profile. With the scattering amplitudes at hand, we compute the conservative potential and scattering angle for the binary system. We find that the result is a non trivial expansion that involves not only the coupling strengths, but also a non trivial dependence on the energy/momentum of the scattered particles.
The barley mutant multiflorus2.b reveals quantitative genetic variation for new spikelet architecture
Authors: Koppolu Ravi , Jiang Guojing , Milner Sara G. , Muqaddasi Quddoos H. , Rutten Twan , Himmelbach Axel , Guo Yu , Stein Nils , Mascher Martin , Schnurbusch Thorsten 
Published: November 2021

Abstract
Key message
Spikelet indeterminacy and supernumerary spikelet phenotypes in barley multiflorus2.b mutant show polygenic inheritance. Genetic analysis of multiflorus2.b revealed major QTLs for spikelet determinacy and supernumerary spikelet phenotypes on 2H and 6H chromosomes.

Abstract
Understanding the genetic basis of yield forming factors in small grain cereals is of extreme importance, especially in the wake of stagnation of further yield gains in these crops. One such yield forming factor in these cereals is the number of grain-bearing florets produced per spikelet. Wild-type barley (Hordeum vulgare L.) spikelets are determinate structures, and the spikelet axis (rachilla) degenerates after producing single floret. In contrast, the rachilla of wheat (Triticum ssp.) spikelets, which are indeterminate, elongates to produce up to 12 florets. In our study, we characterized the barley spikelet determinacy mutant multiflorus2.b (mul2.b) that produced up to three fertile florets on elongated rachillae of lateral spikelets. Apart from the lateral spikelet indeterminacy (LS-IN), we also characterized the supernumerary spikelet phenotype in the central spikelets (CS-SS) of mul2.b. Through our phenotypic and genetic analyses, we identified two major QTLs on chromosomes 2H and 6H, and two minor QTLs on 3H for the LS-IN phenotype. For, the CS-SS phenotype, we identified one major QTL on 6H, and a minor QTL on 5H chromosomes. Notably, the 6H QTLs for CS-SS and LS-IN phenotypes co-located with each other, potentially indicating that a single genetic factor might regulate both phenotypes. Thus, our in-depth phenotyping combined with genetic analyses revealed the quantitative nature of the LS-IN and CS-SS phenotypes in mul2.b, paving the way for cloning the genes underlying these QTLs in the future.
AFM investigation of APAC (antiplatelet and anticoagulant heparin proteoglycan)
Authors: Winzely Maximilian , Jouppila Annukka , Ramer Georg , Lux Laurin , Lendl Bernhard , Barreiro Karina , Lassila Riitta , Friedbacher Gernot 
Published: November 2021

Abstract
Antiplatelet and anticoagulant drugs are classified antithrombotic agents with the purpose to reduce blood clot formation. For a successful treatment of many known complex cardiovascular diseases driven by platelet and/or coagulation activity, the need of more than one antithrombotic agent is inevitable. However, combining drugs with different mechanisms of action enhances risk of bleeding. Dual anticoagulant and antiplatelet (APAC), a novel semisynthetic antithrombotic molecule, provides both anticoagulant and antiplatelet properties in preclinical studies. APAC is entering clinical studies with this new exciting approach to manage cardiovascular diseases. For a better understanding of the biological function of APAC, comprehensive knowledge of its structure is essential. In this study, atomic force microscopy (AFM) was used to characterize APAC according to its structure and to investigate the molecular interaction of APAC with von Willebrand factor (VWF), since specific binding of APAC to VWF could reduce platelet accumulation at vascular injury sites. By the optimization of drop-casting experiments, we were able to determine the volume of an individual APAC molecule at around 600 nm3, and confirm that APAC forms multimers, especially dimers and trimers under the experimental conditions. By studying the drop-casting behavior of APAC and VWF individually, we depictured their interaction by using an indirect approach. Moreover, in vitro and in vivo conducted experiments in pigs supported the AFM results further. Finally, the successful adsorption of APAC to a flat gold surface was confirmed by using photothermal-induced resonance, whereby attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) served as a reference method.
Graphical abstract
Sorption and diffusion properties of untreated and thermally modified beech wood dust
Authors: Majka Jerzy , Rogoziński Tomasz , Olek Wiesław 
Published: November 2021

AbstractDynamic water vapor sorption experiments were carried out using beech wood dust (from untreated and thermally modified wood) of two-particle sizes, (< 25 and 80–250 µm), obtained from abrasive sanding. Sorption isotherms were parameterized with the GAB and GDW models. Dust from thermally modified wood had significantly lower equilibrium moisture content compared to dust from untreated material, due to the reduction in primary sorption sites in treated material. The observed changes were quantified by the coefficients of the GAB and GDW models. Thermal modification and size of wood dust particles had no influence on binding energy of water molecules being linked to the secondary sorption sites. Water diffusivity decreased significantly with increasing moisture content, but only for monolayer sorption. For higher moisture content values, water diffusivity was practically independent of moisture content. These results were found for untreated and thermally modified material as well as for both dust size fractions. The influence of thermal modification on water diffusivity was unclear, which is attributed to the diffusion model, which represents dust particles as spheres and assumes instant hygroscopic equilibrium. Overall, this study indicates that the effectiveness of filtration processes likely depends strongly on sorption and diffusion properties of wood dust only at low moisture contents within the hygroscopic range.
Interleukin-6 as surrogate marker for imaging-based hypoxia dynamics in patients with head-and-neck cancers undergoing definitive chemoradiation—results from a prospective pilot trial
Authors: Rühle Alexander , Wiedenmann Nicole , Fennell Jamina T. , Mix Michael , Ruf Juri , Stoian Raluca , Thomsen Andreas R. , Vaupel Peter , Baltas Dimos , Grosu Anca-L. , Nicolay Nils H. 
Published: November 2021

Abstract
Purpose
Intratumoral hypoxia increases resistance of head-and-neck squamous cell carcinoma (HNSCC) to radiotherapy. [18F]FMISO PET imaging enables noninvasive hypoxia monitoring, though requiring complex logistical efforts. We investigated the role of plasma interleukin-6 (IL-6) as potential surrogate parameter for intratumoral hypoxia in HNSCC using [18F]FMISO PET/CT as reference.

Methods
Within a prospective trial, serial blood samples of 27 HNSCC patients undergoing definitive chemoradiation were collected to analyze plasma IL-6 levels. Intratumoral hypoxia was assessed in treatment weeks 0, 2, and 5 using [18F]FMISO PET/CT imaging. The association between PET-based hypoxia and IL-6 was examined using Pearson’s correlation and multiple regression analyses, and the diagnostic power of IL-6 for tumor hypoxia response prediction was determined with receiver-operating characteristic analyses.

Results
Mean IL-6 concentrations were 15.1, 19.6, and 31.0 pg/mL at baseline, week 2 and week 5, respectively. Smoking (p=0.050) and reduced performance status (p=0.011) resulted in higher IL-6 levels, whereas tumor (p=0.427) and nodal stages (p=0.334), tumor localization (p=0.439), and HPV status (p=0.294) had no influence. IL-6 levels strongly correlated with the intratumoral hypoxic subvolume during treatment (baseline: r=0.775, p<0.001; week 2: r=0.553, p=0.007; week 5: r=0.734, p<0.001). IL-6 levels in week 2 were higher in patients with absent early tumor hypoxia response (p=0.016) and predicted early hypoxia response (AUC=0.822, p=0.031). Increased IL-6 levels at week 5 resulted in a trend towards reduced progression-free survival (p=0.078) and overall survival (p=0.013).

Conclusion
Plasma IL-6 is a promising surrogate marker for tumor hypoxia dynamics in HNSCC patients and may facilitate hypoxia-directed personalized radiotherapy concepts.

Trial registration
The prospective trial was registered in the German Clinical Trial Register (DRKS00003830). Registered 20 August 2015