bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Prevalence of Chemotherapy-induced Peripheral Neuropathy in Onco-hematological Patients
Authors: Frigotto Katia Gleicielly , Garcia Giovana Salviano Braga , Valviesse Vitor Ribeiro Gomes de Almeida , Pires Karina Lebeis 
Published: December 2021

Abstract
Background
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a side effect common to many drugs in cancer treatment. CIPN symptoms are mainly sensory, as paresthesia and pain, especially in body extremities. It can affect the patient's life, requiring a dose reduction or interruption of therapy, which can impact patient's survival.
Method
Twenty-one hematology outpatients who were treated by neurotoxic potential drugs were selected. The Douleur neuropathique 4 questionnaire was applied, a patient form was made for data collection, and the data obtained was analyzed.
Results
The prevalence of CIPN was 47,62%. Five patients (23,81%) did not had signs of neurotoxicity, four (19,05%) patients were classified as Grade 1, seven (33,33% ) as Grade 2, and four (19,05%) as Grade 3, and one (4,76%) patient as Grade 4. Patients who had symptoms of CIPN had already received an average of 55,42% of the scheduled treatment. Three patients (14,29%) had to reduce the dose or change the drugs, and one patient (4,76%) had to discontinue it.
Conclusions
This study support the hypothesis that CIPN is an important side effect in cancer treatments. Being a cause of reducing the dose or temporarily suspending it, which can affect the success of the treatment and patient’s survival.
Universal synthesis of conductive liquid network in polymers enabling elastic printed circuit board technology
Authors: Kang Jiheong , Lee Wonbeom , Kim Hyunjun , Kang Inho , Park Hongjun , Jung Jiyoung , Lee Haeseung , Park Hyunchnag , Ryu Seunghwa , Jeong Jae-Woong 
Published: December 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
The Effects of Administration of Exogenous Albumin Early after Non-cardiac Surgery on Postoperative AKI in Patients with Preoperative Hypoalbuminemia: A Prospective Propensity-score Matching Analysis
Authors: Yan Miao , Zhou Wei-Jie , Xie Min , Zhu Sai-Nan , Li Nan , Li Shuang-Ling 
Published: December 2021

Abstract
BackgroundEvidence have shown that preoperative hypoalbuminemia is independently associated with acute kidney injury (AKI) after non-cardiac surgery. However, little study has investigated the effects of administration of exogenous albumin early after non-cardiac surgery on postoperative AKI in patients with preoperative hypoalbuminemia.MethodsThis study was a secondary analysis of the database of a previously conducted prospective cohort study. Data of 661 adult patients who underwent non-cardiac surgery and were admitted to Surgical Intensive Care Unit (SICU) after surgery from May 1, 2019 to November 30, 2020 were collected. 267 patients with preoperative hypoalbuminemia were screened, and divided into two groups according to whether they were administrated with exogenous albumin on the day of SICU admission. The demographic and perioperative data of the two groups were propensity-matched. ResultsAfter propensity score matching, 64 pairs of patients were included in the final analysis. The patients of albumin group showed relatively higher serum albumin level on postoperative day 1 than that in patients of control group (31.3±3.4 vs. 29.7±3.8, P=0.008), however, no difference was observed in postoperative AKI incidence in patients of the two groups (59.4% vs. 62.5%, P=0.717). Furthermore, there was no difference in other prognostic factors, such as the use of mechanical ventilation, occurrence of other postoperative complications, in-hospital mortality, length of SICU stay and postoperative hospital stay.ConclusionsFor patients with preoperative hypoalbuminemia following non-cardiac surgery, administration of exogenous albumin early after surgery had no beneficial effect on the incidence of postoperative AKI and other clinical outcomes.
Genetic Mapping and Genomic Prediction of Sclerotinia Stem Rot Resistance to Rapeseed/Canola (Brassica Napus L.) at Seedling Stage
Authors: Roy Jayanta , Mendoza Luis E. del Río , Bandillo Nonoy , McClean Phillip E. , Rahman Mukhlesur 
Published: December 2021

Abstract
The lack of complete host resistance and a complex resistance inheritance nature between rapeseed/canola and Sclerotinia sclerotiorum often limits the development of functional molecular markers that enable breeding for sclerotinia stem rot (SSR) resistance. However, genomics-assisted selection has the potential to accelerate the breeding for SSR resistance. Therefore, genome-wide association (GWA) mapping and genomic prediction (GP) was performed using a diverse panel of 337 rapeseed/canola genotypes. Three-weeks old seedlings were screened using the petiole inoculation technique (PIT). Days to wilt (DW) up to 2 weeks and lesion phenotypes (LP) at 3, 4, and 7 days post inoculation (dpi) were recorded. A strong correlation (r = -0.94) between DW and LP_4dpi implied that a single time point scoring at four days could be used as a proxy trait. GWA analyses using single-locus (SL) and multi-locus (ML) models identified a total of 35, and 219 significantly associated SNPs, respectively. Out of these, seventy-one SNPs were identified by a combination of the SL model and any of the ML models, at least two ML models, or two traits. These SNPs explained 1.4-13.3% of the phenotypic variance, and considered as significant, could be associated with SSR resistance. Eighty-one candidate genes with a function in disease resistance were associated with the significant SNPs. Six GP models resulted in moderate to high (0.45-0.68) predictive ability depending on SSR resistance traits. The resistant genotypes and significant SNPs will serve as valuable resources for future SSR resistance breeding. Our results also highlight the potential of genomic selection to improve rapeseed/canola breeding for SSR resistance.
Local Interactions Affect Spread of Resource in a Consumer-resource System With Group Defense
Authors: Arroyo-Esqu Jorge , Hastings Alan , Baskett Marissa L. 
Published: December 2021

Abstract
Integrodifference equations are a discrete time spatially explicit model that describes dispersal of ecological populations through space. This framework is useful to study spread dynamics of organisms and how ecological interactions can affect their spread. When studying interactions such as consumption, dispersal rates might vary with life cycle stage, such as cases with dispersive juveniles and sessile adults. In the non-dispersive stage, resources may engage in group defense to protect themselves from consumption. These local nondispersive interactions may limit the number of dispersing recruits that are produced and therefore affect how fast populations can spread. We present a spatial consumer-resource system using an integrodifference framework with limited movement of their adult stages and group defense mechanisms in the resource population. We model group defense using a Type IV Holling functional response, which limits survival of adult resource population and enhances juvenile consumers production. We find that high mortality levels for sessile adults can destabilize resource at carrying capacity. Furthermore, we find that at high resource densities, group defense leads to a slower local growth of resource in newly invaded regions due to intraspecific competition outweighing the effect of consumption on resource growth.
Soil Microbes Alter the Diversity-Invasibility Relationship by Promoting a Complementarity Effect on Community Invasion Resistance
Authors: Wang Xiao-Yan , Gao Song , Chen Tong , Wang Jiang , Yu Fei-Hai 
Published: December 2021

Abstract
Background Soil microbes can affect both the invasiveness of exotic plants and the invasibility of native plant communities, but it still remains unclear whether soil microbes can influence the relationship between native plant diversity and community invasibility.Methods We constructed native plant communities with three levels of species richness (one, three, or six species) in unsterilized or sterilized soil (i.e., with or without soil microbes) and either prevented their invasion by exotic plants or allowed them to be invaded by each of three exotic species (Solidago canadensis, Erigeron canadensis or Symphyotrichum subulatum), which are highly invasive in China. The soils conditioned by the native plant communities that were not invaded by the exotic species were used as soil microbe inocula to test whether species richness-induced differences in soil microbes affected the growth of each of the three invasive species.Results Compared with soils containing microbes, the absence of soil microbes weakened the negative species richness-invasibility relationship, indicating that soil microbes can contribute to higher invasion resistance in more diverse native plant communities. In the presence of soil microbes, the higher invasion resistance of more diverse communities was mainly ascribed to the complementarity effect. However, soil microbes from communities with a higher species richness did not have a stronger negative effect on the growth of any of the three invasive species. Conclusion Soil microbes can alter the diversity-invasibility relationship by promoting the complementarity effect on community invasion resistance. Our results highlight the importance of integrating the role of soil microbes when testing the diversity-invasibility hypothesis.
Sensory prediction errors increase coding efficiency in mouse visual cortex through gain amplification
Authors: Tang Matthew , Kheradpezhouh Ehsan , Lee Conrad , Dickinson J , Mattingley Jason , Arabzadeh Ehsan 
Published: December 2021

Abstract
The efficiency of sensory coding is affected both by past events (adaptation) and by expectation of future events (prediction). Here we employed a novel visual stimulus paradigm to determine whether expectation influences orientation selectivity in the primary visual cortex. We used two-photon calcium imaging (GCaMP6f) in awake mice viewing visual stimuli with different levels of predictability. The stimuli consisted of sequences of grating stimuli that randomly shifted in orientation or systematically rotated with occasionally unexpected rotations. At the single neuron and population level, there was significantly enhanced orientation-selective response to unexpected visual stimuli through a boost in gain, which was prominent in awake mice but also present to a lesser extent under anesthesia. We implemented a computational model to demonstrate how neuronal responses were best characterized when adaptation and expectation parameters were combined. Our results demonstrated that adaptation and prediction have unique signatures on activity of V1 neurons.
Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding
Authors: Wang Liang , Wen Xin , Wang Zhengmao , Lin Zaisheng , Li Chunhong , Zhou Huilin , Yu Huimin , Li Yuhan , Cheng Yifei , Lou Geer , Pan Junmin , Cao Muqing 
Published: December 2021

Abstract
The transition zone (TZ) of the cilium/flagellum serves as a diffusion barrier that controls the entry/exit of ciliary proteins. Mutations of the TZ proteins disrupt barrier function and lead to multiple human diseases. However, the systematic regulation of ciliary composition and signaling-related processes by different TZ proteins is not completely understood. Here, we reveal that loss of TCTN1 in Chlamydomonas reinhardtii disrupts the assembly of Y-links in the TZ. Proteomic analysis of cilia from WT and three TZ mutants, tctn1, cep290, and nphp4, showed a unique role of each TZ subunit in the regulation of ciliary composition, explaining the phenotypic diversity of different TZ mutants. Interestingly, we found that defects in the TZ impair the formation and biological activity of ciliary ectosomes. Collectively, our findings provide systematic insights into the regulation of ciliary composition by TZ proteins and reveal a link between the TZ and ciliary ectosomes.
Preparation of Polyethylene Glycol Monomethyl Ether Chitosan-diethylenetriamine Pentaacetic Acid and Its Effect on 89SrCl2 Excretion and Radiation Protection in the Digestive Tract of Rats
Authors: Zeng Feng , Xiao Yao , Fu Weilin , Chen Xiangyu , Zeng Hao , Zhang Yi , Liu Chuanchuan , Cai Linghu , Liu Minghua 
Published: December 2021

Abstract
In this study, hydrophilic polymer polyethylene glycol monomethyl ether chitosan-diethylenetriamine pentaacetic acid (mPEGCS-DTPA) was synthesized via chemical synthesis and cross-linking, and its cytotoxicity and radiation protective effect in vivo were studied. The results revealed that mPEGCS-DTPA exhibits good cytocompatibility and increases the excretion of radionuclides through the digestiveand urinary tracts. The pathological results of the small intestine revealed that mPEGCS-DTPA exerts a good radiation-protective effect and could reduce the α and β-emitting radiation-induced damage of the intestinal mucosa. MPEGCS-DTPA can increase the excretion of radionuclides in the digestive tract and exhibits effective protection against radiation.
Acute Stress Induces Cerumen Secretion: Case series of Four Medical Students during Exams
Authors: Sameh Rahma Mohamed , Afify Mohamed , Kamal Manar Ahmed 
Published: December 2021

Abstract
Background and Objectives: Cerumen is a common physiological condition; it only becomes a problem if it causes a hearing impairment or other ear-related symptoms. There is increasing evidence for a relationship between stress and hearing problems. The study aims to understand the association between acute stress and increasing cerumen secretion among medical students during exams. Materials and Methods: The study is a retrospective, single-center, and consecutive case series conducted in Benha University Hospitals in Egypt We defined four cases of medical students who complained of earwax accumulation during their final exams from the 15th to the 13th of July 2021. Results: Four medical students participated in the study. Younger Females and males’ percentages were equal, and the mean age was 19.625 years old. Headache, ear discomfort, and ear pruritus are most common, followed by tinnitus, ear debris, and otitis media with effusion, while hearing loss, fever, and ear pain are slightly rare. The bilateral accumulation of earwax is typical than unilateral accumulation. Remowax was used in almost of cases and then ear wash. Males had high perceived stress, while females had moderate stress. Conclusions: This retrospective case series showed an association between acute stress and excessive cerumen secretion among small medical students during their final exams.
Analysis of Risk Factors for Postoperative Complications in Non-Small Cell Lung Cancer: Comparison With The Japanese National Clinical Database Risk Calculator
Authors: Motono Nozomu , Ishikawa Masahito , Iwai Shun , Yamagata Aika , Iijima Yoshihito , Uramoto Hidetaka 
Published: December 2021

Abstract
Background: Although the risk calculator of the National Clinical Database (RC-NCD) has been widely used to predict the occurrence of mortality and major morbidity in Japan, it has not been demonstrated whether a correlation between the calculated RC-NCD risk score and the actual occurrence of mortality and severe morbidity exists.Methods: The clinical data of 739 patients who underwent pulmonary resection for non-small cell lung cancer were collected, and the risk factors for postoperative morbidity were analyzed to verify the validity of the RC-NCD.Results: The coexistence of asthma (p=0.02), smoking status (p=0.04), forced expiratory volume % in one second (p=0.02), pulmonary lobe (p<0.01), and type of operative procedure (p<0.01) were significant risk factors for postoperative morbidity in the present study, and the body mass index (BMI) (p<0.01) and type of operative procedure (p<0.01) were significant risk factors for severe postoperative morbidity. Furthermore, in patients received lobectomy, coexistence of asthma (p=0.01) and pulmonary lobe (p<0.01) were identified as significant risk factors for postoperative morbidity. Meanwhile, male sex (p=0.01), high BMI (p<0.01),　low vital capacity (p=0.04), and pulmonary lobe (p=0.03) were identified as significant risk factors for severe postoperative morbidity.Conclusions: Given that the pulmonary lobe was a significant risk factor for postoperative morbidity in patients received pulmonary resection and for severe postoperative morbidity in patients received lobectomy, the RC-NCD for postoperative morbidity needs to be modified according to high-risk lobes.Trial registration: The Institutional Review Board of Kanazawa Medical University approved the protocol of this retrospective study (approval number: I392), and written informed consent was obtained from all patients.
Oridonin Attenuates Diabetes‑Induced Renal Fibrosis via Inhibition of the TXNIP/NLRP3 and NF‑κB Pathway in Rats
Authors: Huang Gengzhen , Zhang Yaodan , Zhang Yingying , Zhou Xiaotao , Xu Yuan , Wei Huiting , Ma Yuerong 
Published: December 2021

Abstract
Background: Oxidative stress and its induced inflammation are important pathological processes of diabetic nephropathy (DN). Oridonin, a component isolated from Rabdosia rubescens, possesses remarkable anti-inflammatory, immunoregulatory properties, it is also a newly reported NLRP3 inhibitor. However, the renoprotective effects of Oridonin and the underlying molecular mechanisms have not been explored in DN. We hypothesized that Oridonin could reduce NLRP3 pathway and ameliorate diabetes‑induced renal fibrosis.Methods: We used STZ-induced diabetic rats combined high-fat diet to establish a T2DM animal model, and then treated with Oridonin (10, 20 mg/kg/day) for two weeks. Kidney function and renal fibrosis were assessed. In addition, the expression of inflammatory factors and fibrotic markers were analyzed by western blot.Results: Oridonin treatment preserved kidney function and markedly limited the renal fibrosis size in diabetic rats. The renal fibrotic markers were inhibited in the 10 mg/kg/day group and 20 mg/kg/day group compared to the T2DM group. Moreover, the expression levels of TXNIP/NLRP3 and NF‑κB pathway were decreased in the Oridonin treatment group compared to non-treated group. Conclusions: The NLRP3-inflammasome inhibitor Oridonin reduces renal fibrosis and preserves kidney function in T2DM rat model, which indicates potential therapeutic effect of Oridonin on DN.
Tacit Knowledge Elicitation Process for Industry 4.0
Authors: Fenoglio Enzo , Kazim Emre , Latapie Hugo , Koshiyama Adriano 
Published: December 2021

Abstract
Manufacturers migrate their processes to Industry 4.0 that includes new technologies for improving productivity and efficiency of operations. One of the issues is capturing, recreating, and documenting the tacit knowledge of the aging workers. However, there are no systematic procedures to incorporate this knowledge into Enterprise Resource Planning systems for maintaining a competitive advantage. This paper describes a solution proposal for a tacit knowledge elici-tation process for capturing operational best practices of experienced workers in industrial domains for on-site training. We use Concept Maps mining and domain ontologies to discover and integrate information into a Knowledge Graph in a role game played by human and virtual agents. Ethical and societal concerns are discussed as well.
First draft Genome of Loach (Orenectus shuilongensis; Cypriniformes: Nemacheilidae) provide insights into the Evolution of Cavefish
Authors: Liu Zhi-Jin , Zhang Xiong-Fei , Wen Hua-Mei , Han Ling , Zhou Jiang 
Published: December 2021

Abstract
BackgroundLoaches from the superfamily Cobitoidea (Cypriniformes, Nemacheilidae) are small elongated bottom-dwelling freshwater fishes with several barbels near the mouth, and some species of loach inhabit the underground drainage. The genus Oreonectes with 18 currently recognized loach species represent the three key stages of the evolutionary process (a surface-dwelling lifestyle, facultative cave persistence, and permanent cave dwelling). Some Oreonectes species show typical cave dwelling-related traits, such as partial or complete leucism and regression of the eyes, rendering them as suitable study objects of micro-evolution. Genome information of Oreonectes species is therefore an indispensable research resource of the evolution of cavefishes.ResultWe assembled the genome sequence of O. shuilongensis, a surface-dwelling species, using an integrated approach that combined PacBio single-molecule real-time sequencing and Illumina X-ten paired-end sequencing. The genome assembly contains 803 contigs with N50 values of 5.58 Mb. 25,247 protein-coding genes were predicted, of which 95.65% have been functionally annotated. Meanwhile,we found that dozens of genes related to eye development and melanogenesis were pseudogenised during the evolutionary process in cave environment, providing novel insights into complex phenotypic adaptations of animals in specific environment. ConclusionHere we report the first draft genome assembly of Oreonectes fishes, which is also the first genome reference for Cobitidea fishes. This genome assembly will contribute to the study of the evolution and adaptation of cavefishes within Oreonectes and beyond (Cobitidea) and provid valuable genomic resources for studies on the evolutionary history of the rapid speciation processes of family Nemacheilidae.
Does M-Health Based Exercise (Guidance Plus Education) Improve Efficacy in Patients with Chronic Low-Back Pain？A Preliminary Report on The Intervention’s Significance
Authors: Zheng Fu-ming , Liu Shu-feng , Zhang Shanshan , Yu Qiu-hua , Lo Wai Leung Ambrose , Li Ting-ni , Wang Chuhuai 
Published: December 2021

Abstract
Background: : The utilization of mobile health (m-health) has rapidly expanded during the COVID-19 pandemic, and there is still a lack of relevant clinical data pertaining to chronic low-back pain（CLBP）management. This study was designed to compare the effectiveness of m-health based exercise (via guidance plus education) versus exercise (via guidance) during CLBP management.Methods: Participants (n = 40) were randomly assigned to intervention and control groups. The intervention group received m-health based exercise (via guidance plus education), whereas the control group received m-health based exercise (via guidance). The exercise prescription video and educational content were sent to participants by the application (app), Ding Talk. Repeated-measures analysis of variance was used to test the baseline’s intervention effects, 6-week follow-up, and 18-week follow-up. We selected function（Roland and Morris Disability Questionnaire）and pain intensity (current, mean, and most severe Numeric Rating Scale in the last 2 weeks）as the primary outcomes, changes of negative emotion (depression, anxious), and quality of life as the secondary outcomes.Results: Time’s significant effect was found in pain, function, and health-related quality of life in both groups, but time did not show significant interaction effects. Participants were able to use m-based education with their anxiety and depression after treatment, but the relief only lasted until Week 6. No differences were found on the aspect of mental health-related quality of life.Conclusion: M-health based exercise (via guidance) is a convenient and effective method to treat CLBP. Additionally, plus education is more helpful in improving treatment adherence than guidance only. However, at the last follow-up（18-week）, no significant differences were found between the intervention and control groups.Trial registration:The trial was prospectively registered with the Chinese Clinical Trials Registry Number: ChiCTR2000041459（12/26/2020）.