bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notable Papers and New Directions in Sensors, Signals, and Imaging Informatics
Authors: Hsu William , Baumgartner Christian , Deserno Thomas M. ,   Section Editors of the IMIA Yearbook Section on Sensors, Signals, and Imaging Informatics
Published: September 2021

Summary
Objective: To identify and highlight research papers representing noteworthy developments in signals, sensors, and imaging informatics in 2020.
Method: A broad literature search was conducted on PubMed and Scopus databases. We combined Medical Subject Heading (MeSH) terms and keywords to construct particular queries for sensors, signals, and image informatics. We only considered papers that have been published in journals providing at least three articles in the query response. Section editors then independently reviewed the titles and abstracts of preselected papers assessed on a three-point Likert scale. Papers were rated from 1 (do not include) to 3 (should be included) for each topical area (sensors, signals, and imaging informatics) and those with an average score of 2 or above were subsequently read and assessed again by two of the three co-editors. Finally, the top 14 papers with the highest combined scores were considered based on consensus.
Results: The search for papers was executed in January 2021. After removing duplicates and conference proceedings, the query returned a set of 101, 193, and 529 papers for sensors, signals, and imaging informatics, respectively. We filtered out journals that had less than three papers in the query results, reducing the number of papers to 41, 117, and 333, respectively. From these, the co-editors identified 22 candidate papers with more than 2 Likert points on average, from which 14 candidate best papers were nominated after intensive discussion. At least five external reviewers then rated the remaining papers. The four finalist papers were found using the composite rating of all external reviewers. These best papers were approved by consensus of the International Medical Informatics Association (IMIA) Yearbook editorial board.
Conclusions. Sensors, signals, and imaging informatics is a dynamic field of intense research. The four best papers represent advanced approaches for combining, processing, modeling, and analyzing heterogeneous sensor and imaging data. The selected papers demonstrate the combination and fusion of multiple sensors and sensor networks using electrocardiogram (ECG), electroencephalogram (EEG), or photoplethysmogram (PPG) with advanced data processing, deep and machine learning techniques, and present image processing modalities beyond state-of-the-art that significantly support and further improve medical decision making.
Year 2020 (with COVID): Observation of Scientific Literature on Clinical Natural Language Processing
Authors: Grabar Natalia , Grouin Cyril ,   Section Editors of the IMIA Yearbook Section on Clinical Natural Language Processing
Published: September 2021

SummaryObjectives: To analyze the content of publications within the medical NLP domain in 2020.Methods: Automatic and manual preselection of publications to be reviewed, and selection of the best NLP papers of the year. Analysis of the important issues.Results: Three best papers have been selected in 2020. We also propose an analysis of the content of the NLP publications in 2020, all topics included.Conclusion: The two main issues addressed in 2020 are related to the investigation of COVID-related questions and to the further adaptation and use of transformer models. Besides, the trends from the past years continue, such as diversification of languages processed and use of information from social networks
Psychological Status and Attitude of Breast Cancer Patients Post-COVID-19 Outbreak in Chennai: A Observational Survey Study
Authors: Krishnan Chandralekha , Subramani Latha K.Vivek 
Published: September 2021

Abstract
Introduction The global threat caused by COVID-19 pandemic and the unprecedented lockdown imposed had created emotional stress among the breast cancer patients with dilemma regarding risk of progression of cancer due to interruptions of standard medical care and panic about acquiring the COVID-infection during their frequent visits to the hospital.
Objectives We conducted a questionnaire-based study to assess the psychological impact in this situation affecting their quality of life and their perspective in this current situation.
Materials and Methods Breast cancer patients who had been recently diagnosed, those who were on chemotherapy and visited our OPD in the month of July during the COVID-19 pandemic were assessed for their treatment-related perspectives with a questionnaire. Psychological status was analyzed with GAD-7 (generalized anxiety disorder questionnaire) and PHQ-9 (patient health questionnaire).
Results A total of 202 breast cancer patients were included when lockdown was relaxed after a period of 3 months and COVID-19 status was still up trending. The clinical profile and patient-related information were collected from the medical records. Of them, 55.4% (112 patients) were within the city, 35.1% (71 patients) were from suburban areas of the city, and 9.4% (19 patients) were from adjacent districts/rural areas. Also, 56% were educated. Of these, 87% wanted to continue treatment and did not bother about the spread of the infection, while remaining patients’ main concern was to avoid infection than to get oncological management. Also, 76% were aware about the COVID-19 infection and sequelae. A total of 80% patients were aware of the consequences due to delay in cancer treatment. Of these patients, 51%, 42% and 7% had mild, moderate, and severe anxiety respectively and 69%, 25% and 6% had mild, moderate, and severe depression respectively. The severe anxiety and depression correlated with metastatic breast cancer and educated patients.
Conclusion This study reflected that the breast cancer patients were more bothered to continue the treatment in spite of the existing pandemic.
Comparison of Various Radiotherapy Dose Fractionation Schedules in Palliation of Bone Metastasis
Authors: Fernandes Donald J. , Athiyamaan Mariappan Senthiappan , Rao Sandesh , Shankar Sharaschandra , Krishna Abhishek 
Published: September 2021

Abstract
Introduction Bone metastasis is a common manifestation of malignancy. Bone metastases causes various morbidities and affect the quality of life. External beam radiotherapy is the mainstay of treatment of uncomplicated painful bone metastases. Different radiotherapy fractionation schedules are in practice for palliation of painful bone metastases.
Objectives This study was aimed to compare and report the outcomes of various fractionation schedules of radiation therapy (RT) in terms of pain relief and quality of life in patients with painful bone metastases.
Materials and Methods Eighty patients were randomized into four treatment arms with different RT fractionation schedules, namely, 8 Gy in 1 fraction, 20 Gy in 5 fractions, 24 Gy in 6 fractions, and 30 Gy in 10 fractions. Patients were assessed for pain by visual analog scale (VAS), performance status and quality of life before initiating the treatment, on the day of completion of treatment, and 1 week, 1 month, and 3 months of treatment completion.
Results Majority of the metastases constituted from breast followed by lung cancer. Of these, 27.5% had metastases to the thoracic vertebra, 26.25% to the lumbar vertebra, 22.5% to the pelvis, 8.75% to the sternum, 6.25% each to cervical vertebra and femur, and 1.25% each to humerus and ribs. The mean VAS score prior to start of RT was 5.31, 5.21, 5.54, and 4.87 in arms A, B, C, and D, respectively. At the end of treatment, the scores were 3.0, 3.29, 2.77, and 2.47, respectively. At the end of 3 months, the scores were 1.54, 0.57, 0.54, and 0.60, respectively. The pain reduction was significant in all the four arms (p < 0.05). Also, 25% of the patients’ arm A had complete pain relief, whereas 45% of patients in arms B, C, and D had complete pain relief. In arm A, the performance status failed to improve at 3 months when compared with 1-week post-RT but the improvement was significant in the remaining three arms. There was improvement in the quality of life in all the arms, both in terms of function and symptoms. The mean score of symptomatic quality of life based on the EORTC BM22 module prior to start of RT was 38.14, 34.91, 28.85, and 29.17 in arms A, B, C, and D, respectively. There was a significant drop to 9.29, 6.55, 5.13, and 6.11 at 1-month posttreatment in the four arms, respectively. The outcomes in terms of functional quality of life showed a similar trend.
Conclusion This study demonstrated that pain reduction by various RT fractionation schedules were similar, and no statistically significant difference was noted. Performance status and quality of life improved in all the four treatment arms post-RT.
Evaluation of Telomerase Reverse Transcriptase Expression in Squamous Cell Carcinoma of the Skin
Authors: Kant Nimita , Jayaraj Perumal Senthiappan 
Published: September 2021

Abstract
Introduction Squamous cell carcinoma (SCC) is highly invasive malignant tumor showing keratinocytic differentiation and is often associated with chronic exposure to UV light. Telomerase is RNA dependent DNA polymerase that causes addition of telomeric repeat DNA sequences to chromosomal ends. Recently, UV signature mutations have been identified in core promoter region of TERT gene, which encodes the main catalytic subunit leading to overexpression in cutaneous melanoma. However, its role and expression pattern have not been studied in eyelid skin SCC.
Objectives Present study aimed to analyze the presence of telomerase reverse transcriptase (TERT) in eyelid SCC, as its expression pattern and mutational status have not been studied in SCC.
Materials and Methods Nineteen cases of eyelid SCC were evaluated for the presence of TERT protein using monoclonal antibody against TERT, and its mutational status was verified using PCR and DNA sequencing. Bioedit software was used for analyzes and primers were vindicated using NCBI Primer Blast. Results were correlated with clinicopathological features of SCC.
Results A C to T mutation was observed in 6 of 19 SCC cases. Positive expression of TERT was found in 57% of the cases analyzed and it showed a significant association with keratinocytic differentiation (p = 0.04).
Conclusion Relation between TERT promoter mutation and TERT immunohistochemistry is studied for the first time in eyelid skin SCC. Our results suggested that overexpression of TERT may contribute to the aggressive behavior associated with SCC and such patients may warrant aggressive treatment.
An Analysis of Acute Adverse Drug Reactions Occurring in Day Care Chemotherapy Setting in a Tertiary Care Cancer Centre
Authors: R. Senthil J. , A. Santa , KB Pavan , P. Rakesh , G. Pravanika , G. Pravanika , Ch Narander , MMVT Krishna ,   Sekhar
Published: September 2021

Abstract
Introduction Acute adverse drug reactions (ADRs) in day care chemotherapy are not uncommon and easily manageable many a time. However, sometimes they may lead to untoward events. It is of paramount importance to document and analyze such events in contemporary medical oncology practice for the best utilization and planning of available personnel and resources.
Objectives This study was aimed to analyze the acute ADRs occurring in day care cancer chemotherapy setting.
Materials and Methods All acute ADRs reported in day care cancer chemotherapy setting, during the administration of chemotherapy, at Basavatarakam Indo American Cancer Hospital, Hyderabad, Telangana, India, were included in the study from June 15, 2020 to September 30, 2020. The ADRs were classified in to anaphylactic, allergic, and gastrointestinal (nausea/vomiting/heart burns/chest tightness). All ADRs were graded according to CTCAE version 5.0. Suspected drugs, time to reaction, and corrective measures were analyzed.
Results During the study period, a total of 8,600 sessions of day care chemotherapy were administered. ADRs were noticed in 83 cases (~1%). Among the reported ADRs, anaphylactic reactions were noted in 20 patients (24%); allergic reactions of grades 1 and 2 were noted in 41 patients (49%). Gastrointestinal ADRs were noted in 30 patients (36%). Adverse reactions are mostly seen in oxaliplatin (22.8%), rituximab (14.4%), paclitaxel (15.6%), carboplatin (13.2%), and docetaxel (7.2%). In grade-I (10%) and grade-II (63%) resections, supportive treatment was provided and chemotherapy was continued. Grade-III ADRs were noted in 21 patients (25%) out of whom, 3 patients required short-term intensive care, chemotherapy was withheld until the next cycle in one patient, and chemotherapy regimen was changed in 3 patients. No patient died of ADR.
Conclusion Serious ADRs are rare in contemporary medical oncology practice during day care chemotherapy administration. Most acute ADRs were easily managed.
A fast, low-energy multi-state phase-change artificial synapse based on uniform partial-state transitions
Authors: Go Shao Xiang , Lee Tae Hoon , Elliott Stephen R. , Bajalovic Natasa , Loke Desmond K. 
Published: September 2021

Complementary metal–oxide–semiconductor (CMOS)-based neural architectures and memristive devices containing many artificial synapses are promising technologies that are being developed for pattern recognition and machine learning. However, the volatility and design complexity of traditional CMOS architectures, and the trade-off between the operating time and power consumption of conventional memristive devices, have tended to impede the path to achieve the interconnectivity/compactness and information density of the brain using either approach. Here, by developing a nanoscale deposit-only-metal-electrode-fabrication-based uniform-partial-state-transition-facilitated approach, we demonstrate a fast artificial synapse with a Rapid-operating-time, Intermediate-bias-range, Multiple-states, and Several-synaptic-functions (RIMS) synapse, implemented using deposit-only, nanopillar-based Ge2Sb2Te5-type memristive devices. A previously unconsidered, fast, paired-pulse facilitation/depression using ∼50 ns spikes with an ∼1 µs inter-spike interval within an ∼1 V range and with a low-energy consumption of ∼1.8 pJ per paired-spike as well as a previously inaccessible multi-state, rapid long-term potentiation/depression with ∼15 distinct states using ∼50 ns spikes within a 0.7/1.4 V range was achieved. Fast spike-timing-dependent plasticity using ∼50 ns spikes with an ∼1 µs inter-spike interval within a 1.3 V range was also achieved. Electro-thermal simulations reveal a uniform-partial-state-transition-facilitated variation in conductance states. This artificial synapse, equipped with a nanoscale deposit-only-metal-electrode-fabrication-based uniform-partial-state-transition-facilitated framework, shows the potential for a substantial overall performance improvement in artificial-intelligence tasks.
Stress analysis and lifetime prediction for Ti–6Al–4V welding joint under fatigue loading
Authors: Liu Yang , Xia Shangzhou , Song Jianan , Qi Hongyu , Li Shaolin , Yang Xiaoguang , Shi Duoqi 
Published: September 2021

A welded joint has a complex gradient microstructure. The effects of local deformation in the fusion zone, heat-affected zone (HAZ), and other areas, on the macroscopic fatigue properties of an inhomogeneous welded joint, are not fully understood. Thus, it is necessary to correlate the microstructural features and their related local deformation mechanisms with macroscopic fatigue properties. In this study, cyclic stress–strain curves and lifetime model parameters of materials in different HAZs were determined by hardness distribution and base–metal material properties. A user element subroutine was developed in the elastic–plastic finite element analysis to obtain the local stress and strain in the joint. ‘Danger points’ were selected to predict fatigue lifetime with the Manson–Coffin damage equation. The prediction results agreed closely with experimental observations within the low-cycle fatigue lifetime regime. Highlights A new LCF life analysis method, for coated specimens, was developed based on the fracture mechanics. Life prediction method for coated specimens was proposed and verified by LCF tests. Coating-induced lifetime degradation was analysed quantitatively at different temperatures. Effects of stress amplitude on the surface crack initiation were investigated.
Reinforcement learning-enhanced protocols for coherent population-transfer in three-level quantum systems
Authors: Brown Jonathon , Sgroi Sofia , Giannelli Luigi , Paraoanu Gheorghe Sorin , Paladino Elisabetta , Falci Giuseppe , Paternostro Mauro , Ferraro Alessandro 
Published: September 2021

Abstract
We deploy a combination of reinforcement learning-based approaches and more traditional optimization techniques to identify optimal protocols for population transfer in a multi-level system. We constrain our strategy to the case of fixed coupling rates but time-varying detunings, a situation that would simplify considerably the implementation of population transfer in relevant experimental platforms, such as semiconducting and superconducting ones. Our approach is able to explore the space of possible control protocols to reveal the existence of efficient protocols that, remarkably, differ from (and can be superior to) standard Raman, stimulated Raman adiabatic passage or other adiabatic schemes. The new protocols that we identify are robust against both energy losses and dephasing.
Semi-inclusive lepto-production of hidden-charm exotic hadrons *
Authors: Yang Zhi , Guo Feng-Kun 
Published: September 2021

Abstract
We investigate the semi-inclusive production of hidden-charm exotic states, including the

,

,

and pentaquark

states, in lepton-proton scattering processes. These hadrons are close to the thresholds of a pair of charm and anticharm hadrons and are assumed to possess a hadronic molecular structure as their main feature. To provide order-of-magnitude estimates of the cross sections, we use Pythia to simulate the short-distance productions of the constituent hadrons, which then rescatter to form exotic hadrons. The estimates for the

and

states are not in conflict with the upper limits measured in the COMPASS experiment for the exclusive photoproduction process. The results indicate that the considered hidden-charm states can be copiously produced at the proposed electron-ion colliders EicC and US-EIC.
Monitoring of optical properties of deep lake water
Authors: Ryabov E. , Tarashansky B. 
Published: September 2021

Abstract
We present the results of the one year monitoring of absorption and scattering lengths of light with wavelengths in the range of 375 nm to 532 nm within the effective volume of the deep underwater neutrino telescope Baikal-GVD, which were measured by a device
named ≪BAIKAL-5D≫. ≪BAIKAL-5D≫ was installed during the 2020 winter expedition at a depth of 1250 m. To carry out the optical measurements, we use a device with a shaded point-like isotropic light source having a spectral resolution of about 3 nm. A wide angle light receiver is moved by a stepper motor so that the distance between the receiver and the light source can vary from 0.9 m to 7.4 m. The absorption and scattering lengths were measured every week in 6 spectral points. The short-time variation of absorption length was estimated.
Experience in application of modern technologies of measuring the structure of currents in the upstream waters of large hydroelectric complexes (on the example of the Kama HPP)
Authors: Ljahin U S , Bogomolov A V , Lepihin A P 
Published: September 2021

Abstract
The creation of reservoirs on watercourses leads to significant changes in the hydrological regime of water bodies: it allows to smooth out the peaks of maximum water discharge during the flood period and to regulate low runoff. The reservoirs with a significant storage capacity enable to solve a wide range of water management problems, among which are: using the falling water energy for hydropower purposes, ensuring uninterrupted water supply and navigation. In view of the fact that dams are generally managed by hydropower companies, the regime for regulating downstream water mass discharges is often determined by the schedule of daily electricity consumption. Intraday changes in the volume of water discharge through the hydroelectric units of hydroelectric power plants form multidirectional flows in the upstream, which can affect the work of other water users. This paper examines the impact of intraday changes in flow rates of downstream water discharges on the dynamic and physical properties of the water mass in the area of the drinking water intake heads of the city of Perm.
A three-dimensional thermohydrodynamic model for Krasnoyarsk Reservoir
Authors: Zinoviev A T , Koshelev K B , Marusin K V 
Published: September 2021

Abstract
The paper presents a 3D model for a deep flowing water body based on the open software package Delft3D to describe and predict thermohydrodynamic (THD) processes in existing and projected reservoirs of Siberia. As an example, a 3D model for non-stationary THD processes of the Krasnoyarsk Reservoir was built and tested. For its construction, we developed a Digital Relief Model (DRM) for the Krasnoyarsk Reservoir basin, generated a finite-difference grid, identified the empirical constants and formulated the initial and boundary conditions. Numerical simulation of current velocity and water temperature of the reservoir for spring/summer of the scenario year was performed.
Climate change impact on the inflow to the reservoirs of the Moscow water supply system
Authors: Korobkina E , Filippova I 
Published: September 2021

Abstract
The dynamics of long-term fluctuations in the inflow to the reservoirs of the Moscow water supply system for different time intervals is analysed. The article deals with part of the Moscow drinking water supply system, namely Moskvoretskaya Water System and Vazuza Hydrotechnical System (MVHS). A significant change in the parameters of the inflow distribution is shown. It is concluded that it is necessary to clarify the rules for the operation of reservoirs system under conditions of hydrological regime changes.
Calculation of the maximum levels of lakes in the north-west Russia in the absence of hydrometric observation data
Authors: Davydenko E V , Sikan A V 
Published: September 2021

Abstract
The methodology for calculation the maximum water levels of unexplored lakes is examined in the article. This methodology is based on the generalization of all available information about the lakes’ regime in the North-West of the Russian Federation. The dependence of the standard deviation of the upper water level on the average long-term upper level is revealed for medium and small lakes with a specific drainage area of less than 100. The recommendations for calculation of the parameters of the probability curve of maximum levels of unexplored lakes of the North-West of Russia and of the Southern part of the Kola Peninsula are developed. It is proposed to determine the probability curve of maximum water levels of an unexplored lake not with accordance to the similar water tank, but on the basis of regional generalizations, which integrates all available information about the lake regime of the studied area.