bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporating patient-centered quality-of-life measures for outcome assessment after Chiari malformation type I decompression in a pediatric population: a pilot study
Authors: Savchuk Solomiia , Jin Michael C. , Choi Stephanie , Kim Lily H. , Quon Jennifer L. , Bet Anthony , Prolo Laura M. , Hong David S. , Mahaney Kelly B. , Grant Gerald A. 
Published: November 2021

OBJECTIVE
Optimal management of pediatric Chiari malformation type I (CM-I) is much debated, chiefly due to the lack of validated tools for outcome assessment, with very few tools incorporating patient-centered measures of health-related quality of life (HRQOL). Although posterior fossa decompression (PFD) benefits a subset of patients, prediction of its impact across patients is challenging. The primary aim of this study was to investigate the role of patient-centered HRQOL measures in the assessment and prediction of outcomes after PFD.

METHODS
The authors collected HRQOL data from a cohort of 20 pediatric CM-I patients before and after PFD. The surveys included assessments of selected Patient-Reported Outcomes Measurement Information System (PROMIS) health domains and were used to generate the PROMIS preference (PROPr) score, which is a measure of HRQOL. PROMIS is a reliable standardized measure of HRQOL domains such as pain, fatigue, depression, and physical function, which are all relevant to CM-I. The authors then compared the PROPr scores with Chicago Chiari Outcome Scale (CCOS) scores derived from time-matched clinical documentation. Finally, the authors used the PROPr scores as an outcome measure to predict postsurgical HRQOL improvement at 1 year on the basis of patient demographic characteristics, comorbidities, and radiological and physical findings. The Wilcoxon signed-rank test, Mann-Whitney U-test, and Kendall’s correlation were used for statistical analysis.

RESULTS
Aggregate analysis revealed improvement of pain severity after PFD (p = 0.007) in anatomical patterns characteristic of CM-I. Most PROMIS domain scores trended toward improvement after surgery, with anxiety and pain interference reaching statistical significance (p < 0.002 and p < 0.03, respectively). PROPr scores also significantly improved after PFD (p < 0.008). Of the baseline patient characteristics, preexisting scoliosis was the most accurate negative predictor of HRQOL improvement after PFD (median −0.095 vs 0.106, p < 0.001). A correlation with modest magnitude (Kendall’s tau range 0.19–0.47) was detected between the patient-centered measures and CCOS score.

CONCLUSIONS
The authors observed moderate improvement of HRQOL, when measured using a modified panel of PROMIS question banks, in this pilot cohort of pediatric CM-I patients after PFD. Further investigations are necessary to validate this tool for children with CM-I and to determine whether these scores correlate with clinical and radiographic findings.
Electromagnetic performance and thermal analysis of a novel permanent magnet fluxed-switching coupler
Authors: Ye Lezhi , Zhang Yulong , Cao Mingguang 
Published: November 2021

To solve the problem of complex operating device and permanent magnets (PMs) demagnetization at high temperature, a new type of permanent magnet fluxed-switching coupler (PMC) with synchronous rotating adjuster is proposed. Its torque can be adjusted by rotating a switched flux angle between the adjuster and PMs along the circumferential direction. The structural feature and working principle of the PMC are introduced. The analytical model of the novel PMC was established. The torque curves are calculated in transient field by using the three-dimensional finite element method (3-D FEM). The temperature distribution of the novel PMC under rated condition is calculated by 3-D FEM, and the temperature distribution of the PM is compared with that of the conventional PMC. The simulation and test results show that the maximum temperature of copper disc and PM of the novel PMC are 100 °C and 48 °C respectively. The novel PMC can work stably for a long time under the maximum load condition.
A novel gateway node reconfiguration method of IOT based on hierarchical coding particle swarm optimization
Authors: Shu Wei , He Dajiang , Shu Jun 
Published: November 2021

In order to overcome the problems of low channel utilization, low transmission success rate and high data transmission delay in current gateway node reconfiguration methods of IOT, this paper proposes a novel gateway node reconfiguration method of IOT based on hierarchical coding particle swarm optimization. Based on the IOT network model, this paper analyzes the delay characteristics of the IOT, and constructs the object function of the gateway node reconfiguration of IOT. By monotone decreasing inertia weight strategy, the coding particle swarm optimization is optimized, and the reconfiguration objective function of the gateway node of IOT by using the optimized particle swarm optimization algorithm is solved. Experimental results show that the channel utilization ratio of the proposed method is higher than 90%, the success rate of information transmission is more than 80%, and the data transmission delay is less than 0.5 s, which indicates that the proposed method has high channel utilization, high transmission success rate and low data transmission delay.
AMPİRİZM: İNGİLİZ EKONOMİ POLİTİK VE HUKUKİ DÜZENİNİN KURUCU EPİSTEMOLOJİSİNİN FELSEFİ KÖKENLERİ VE GELİŞİMİ
Authors: AKMAN Şefik Taylan 
Published: November 2021

İngiltere’de ampirizm, feodalizmden kapitalizme geçiş sürecinde doğa bilimleri ve felsefede yeni bir epistemolojik anlayış ve yöntem olarak ortaya çıkmıştır. Ampiristlere göre insanın sahip olduğu bütün bilgi duyumsal algılamadan kaynaklanmaktadır. Gözlem ve deneyime dayanmayan doğuştan hiçbir bilgi yoktur. Onlar bilginin edinilmesinde algılayan ve deneyimleyen özneyi merkezileştirerek felsefeyi dünyevileştirme eğilimindedirler. Kapitalizmin gelişimine koşut olarak bu dünyevileşme, burjuvazinin ekonomi politik ve hukuki ideolojisinin temellerini biçimlendirmiştir. Üretim kapasitesinin ve verimliliğin artırılması için yeni tekniklerin kullanılması zorunluluğu bilimsel araştırmaları teşvik etmiştir. Ampirizm bu aşamada deney ve gözleme verdiği önem ile bilimsel bir metodoloji olarak ön plana çıkmıştır. Aynı dönemde İngiltere’de ampirizm, felsefinin de bir konusu haline gelmiştir. Epistemolojik bir hüviyet kazanan felsefi ampirizm bilginin kaynağı, nasıl edinildiği, sınırları ve insanın bilme kapasitesi gibi sorunlarla ilgilenmiştir.
Bu çalışmada ampirizmin ortaya çıkışı ve gelişimi öncelikle doğa bilimlerinin bir yöntemi olarak benimsenmesi ekseninde ele alınacaktır. Ardından ampirist felsefe Bacon, Hobbes, Locke, Berkeley ve Hume gibi en önemli temsilcilerinin epistemolojik görüşleri çerçevesinde değerlendirilecektir. 16. yüzyıldan 18. yüzyıla uzanan süreçte, ampirist filozofların epistemolojik yaklaşımlarındaki değişimler İngiliz ekonomi politik ve hukuki düzenindeki dönüşümler göz önüne alınarak ayrıntılı bir biçimde incelenecektir.
COGNITIVE RESEARCH OF MILITARY METAPHOR IN POLITICAL COMMUNICATIO
Authors: Хазиева Рушана 
Published: November 2021

The article discusses the use of metaphors when covering armed conflicts in media. The ambiguous nature of the conflict and the subjectivity of perception of this phenomenon determine the specific usе of metaphor as an evaluative tool capable to change the addressee’s picture of the world. Metaphors are easily activated in the mind of a person, produce an automatic perception of a country's policy, which predetermines their high functionality for propaganda purposes. Ag- gressive rhetoric in political media discourse serves as a means of language manifestation of the goals of ideological suggestion and the creation of suggestive semantic effects. Ideological beliefs and values in the form of political metaphors are manifested and contribute to the implementation of the strategy of discredit in political discourse, influencing the addressee.
Human Sperm Remain Motile After a Temporary Energy Restriction but do Not Undergo Capacitation-Related Events
Authors: Marín-Briggiler Clara I. , Luque Guillermina M. , Gervasi María G. , Oscoz-Susino Natalia , Sierra Jessica M. , Mondillo Carolina , Salicioni Ana M. , Krapf Darío , Visconti Pablo E. , Buffone Mariano G. 
Published: November 2021

To acquire fertilization competence, mammalian sperm must undergo several biochemical and physiological modifications known as capacitation. Despite its relevance, the metabolic pathways that regulate the capacitation-related events, including the development of hyperactivated motility, are still poorly described. Previous studies from our group have shown that temporary energy restriction in mouse sperm enhanced hyperactivation, in vitro fertilization, early embryo development and pregnancy rates after embryo transfer, and it improved intracytoplasmic sperm injection results in the bovine model. However, the effects of starvation and energy recovery protocols on human sperm function have not yet been established. In the present work, human sperm were incubated for different periods of time in medium containing glucose, pyruvate and lactate (NUTR) or devoid of nutrients for the starving condition (STRV). Sperm maintained in STRV displayed reduced percentages of motility and kinematic parameters compared to cells incubated in NUTR medium. Moreover, they did not undergo hyperactivation and showed reduced levels of ATP, cAMP and protein tyrosine phosphorylation. Similar to our results with mouse sperm, starvation induced increased intracellular Ca2+ concentrations. Starved human sperm were capable to continue moving for more than 27 h, but the incubation with a mitochondrial uncoupler or inhibitors of oxidative phosphorylation led to a complete motility loss. When exogenous nutrients were added back (sperm energy recovery (SER) treatment), hyperactivated motility was rescued and there was a rise in sperm ATP and cAMP levels in 1 min, with a decrease in intracellular Ca2+ concentration and no changes in sperm protein tyrosine phosphorylation. The finding that human sperm can remain motile for several hours under starvation due to mitochondrial use of endogenous metabolites implies that other metabolic pathways may play a role in sperm energy production. In addition, full recovery of motility and other capacitation parameters of human sperm after SER suggests that this treatment might be used to modulate human sperm fertilizing ability in vitro.
Case Report: Area of Focus of Myocardial Infarction With Non-obstructive Coronary Arteries in Eosinophilic Granulomatosis With Polyangiitis
Authors: Cui Xiaoxian , Peng Yang , Liu Jun , Dong Yugang , Wu Zexuan , Chen Yili 
Published: November 2021

Background: Eosinophilic granulomatosis with polyangitis manifested as myocardial infarction with non-obstructed coronary arteries (MINOCA) is rarely reported.Case: We report a 43-year-old male patient without any cardiovascular risk factors presenting with acute chest pain. Electrocardiogram was suggestive of acute anterior and inferior myocardial infarction. MINOCA was confirmed based on significant elevated cardiac troponin and normal coronary arteries. Cardiac magnetic resonance (CMR) imaging revealed extended late gadolinium enhancement (LGE). Further diagnosis of eosinophilic granulomatosis with polyangitis (EGPA) was based on clinical manifestations and auxiliary examination. Subsequent immunosuppressive therapy led to regression of symptoms and significant resolution of LGE on CMR.Conclusion: Our case highlights that EGPA can be a rare cause of MINOCA. CMR is useful for differentiation diagnosis and evaluation of cardiac involvement.
The Retina in Patients With Triple A Syndrome: A Window Into Neurodegeneration?
Authors: Ulgiati Fiorenza , Lhoir Sophie , Balikova Irina , Tenoutasse Sylvie , Boros Emese , Vilain Catheline , Heinrichs Claudine , Brachet Cécile 
Published: November 2021

ObjectiveExperimental evidence suggests that the clinical manifestations of Triple A syndrome result from oxidative stress. Several conditions caused by oxidative stress display retinal involvement. Our objective was to assess the retina and optic nerve involvement in children with Triple A syndrome.MethodsEleven patients with genetically proven Triple A syndrome followed-up in our centre were approached for study participation. The main outcome was the measurement of the thicknesses of the different retinal layers by Optical Coherence Tomography (OCT).Results9 patients with triple A syndrome had OCT measurements. 7 patients were children and 2 were adults; 4 were females and 5 were males. The 7 paediatric patients had at least two OCT measured at a mean interval of 7.9 months after the first one. The average Retinal Nerve Fibre Layer thickness was 74 ± 10 µm in patients compared to the paediatric reference range of 100 ± 2 µm (p&lt;0.05).Conclusions and RelevanceThis is the first study to document retinal layer thicknesses in a series of patients with Triple A syndrome. Nearly all retinal thickness and peripapillary RNFL measurements were very significantly inferior to the reference range in Triple A patients, whatever their age. RNFL thinning was more marked at the temporal part of the optic nerve. OCT being non-invasive, it represents a promising tool to assess the severity of neurodegeneration in patients with Triple A syndrome.
Influence of Particle Composition and Size on the Accuracy of Low Cost PM Sensors: Findings From Field Campaigns
Authors: Gramsch E. , Oyola P. , Reyes F. , Vásquez Y. , Rubio M. A. , Soto C. , Pérez P. , Moreno F. , Gutiérrez N. 
Published: November 2021

In the last decade, many low-cost monitoring sensors and sensor-networks have been used as an alternative air quality assessment method. It is also well known that these low cost monitors have calibration, accuracy and long term variation problems which require various calibration techniques. In this work PM2.5and PM10low cost sensors (Plantower and Nova Fitness) have been tested in five cities under different environmental conditions and compared with collocated standard instruments. Simultaneously, particle composition (organic and black carbon, sulfate, nitrate, chloride, ammonium, and chemical elements) has been measured in the same places to study its influence on the accuracy. The results show a very large variability in the correlation between the low cost sensors and collocated standard instruments depending on the composition and size of particles present in the site. The PM10correlation coefficient (R2) between the low cost sensor and a collocated regulatory instrument varied from to 0.95 in Temuco to 0.04 in Los Caleos. PM2.5correlation varied from 0.97 to 0.68 in the same places. It was found that sites that had higher proportion of large particles had lower correlation between the low cost sensor and the regulatory instrument. Sites that had higher relative concentration of organic and black carbon had better correlation because these species are mostly below the 1 μm size range. Sites that had higher sulfate, nitrate or SiO2concentrations in PM2.5or PM10had low correlation most likely because these particles have a scattering coefficients that depends on its size or composition, thus they can be classified incorrectly.
Southern Ocean Food Web Modelling: Progress, Prognoses, and Future Priorities for Research and Policy Makers
Authors: McCormack Stacey A. , Melbourne-Thomas Jessica , Trebilco Rowan , Griffith Gary , Hill Simeon L. , Hoover Carie , Johnston Nadine M. , Marina Tomás I. , Murphy Eugene J. , Pakhomov Evgeny A. , Pinkerton Matt , Plagányi Éva , Saravia Leonardo A. , Subramaniam Roshni C. , Van de Putte Anton P. , Constable Andrew J. 
Published: November 2021

Graphical AbstractGraphical summary of multiple aspects of Southern Ocean food web structure and function including alternative energy pathways through pelagic food webs, climate change and fisheries impacts and the importance of microbial networks and benthic systems.
Identification of lncRNA–miRNA–mRNA Networks Linked to Non-small Lung Cancer Resistance to Inhibitors of Epidermal Growth Factor Receptor
Authors: Wang Ting , Yang Chengliang , Li Bing , Xing Ying , Huang Jian , Zhang Yangping , Bu Shanshan , Ge Hong 
Published: November 2021

Background: Tyrosine kinase inhibitors that act against epidermal growth factor receptor (EGFR) show strong efficacy against non-small cell lung cancer (NSCLC) involving mutated EGFRs. However, most such patients eventually develop resistance to EGFR-TKIs. Numerous researches have reported that messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) may be involved in EGFR-TKI resistance, but the comprehensive expression profile and competitive endogenous RNA (ceRNA) regulatory network between mRNAs and ncRNAs in EGFR-TKI resistance of NSCLC are incompletely known. We aimed to define a ceRNA regulatory network linking mRNAs and non-coding RNAs that may mediate this resistance.Methods: Using datasets GSE83666, GSE75309 and GSE103352 from the Gene Expression Omnibus, we identified long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and mRNAs differentially expressed between NSCLC cells that were sensitive or resistant to EGFR-TKIs. The potential biological functions of the corresponding differentially expressed genes were analyzed based KEGG pathways. We combined interactions among lncRNAs, miRNAs and mRNAs in the RNAInter database with KEGG pathways to generate transcriptional regulatory ceRNA networks associated with NSCLC resistance to EGFR-TKIs. Kaplan-Meier analysis was used to assess the ability of core ceRNA regulatory sub-networks to predict the progression-free interval and overall survival of NSCLC. The expression of two core ceRNA regulatory sub-networks in NSCLC was validated by quantitative real-time PCR.Results: We identified 8,989 lncRNAs, 1,083 miRNAs and 3,191 mRNAs that were differentially expressed between patients who were sensitive or resistant to the inhibitors. These DEGs were linked to 968 biological processes and 31 KEGG pathways. Pearson analysis of correlations among the DEGs of lncRNAs, miRNAs and mRNAs identified 12 core ceRNA regulatory sub-networks associated with resistance to EGFR-TKIs. The two lncRNAs ABTB1 and NPTN with the hsa-miR-150–5p and mRNA SERPINE1 were significantly associated with resistance to EGFR-TKIs and survival in NSCLC. These lncRNAs and the miRNA were found to be down-regulated, and the mRNA up-regulated, in a resistant NSCLC cell line relative to the corresponding sensitive cells.Conclusion: In this study, we provide new insights into the pathogenesis of NSCLC and the emergence of resistance to EGFR-TKIs, based on a lncRNA-miRNA-mRNA network.
The Significance of RHD Genotyping and Characteristic Analysis in Chinese RhD Variant Individuals
Authors: Ying Yanling , Zhang Jingjing , Hong Xiaozhen , Xu Xianguo , He Ji , Zhu Faming 
Published: November 2021

BackgroundRhD is the most important and complex blood group system because of its highly polymorphic and immunogenic nature. RhD variants can induce immune response by allogeneic transfusion, organ transplantation, and fetal immunity. The transfusion strategies are different for RhD variants formed by various alleles. Therefore, extensive investigation of the molecular mechanism underlying RhD variants is critical for preventing immune-related blood transfusion reactions and fetal immunity.MethodsRhD variants were collected from donors and patients in Zhejiang Province, China. The phenotypes were classified using the serologic method. The full coding regions of RHD gene were analyzed using the PCR-SBT method. The multiplex ligation-dependent probe amplification (MLPA) assay was used to analyze the genotype and gene copy number. SWISS-MODLE and PyMOL software were used to analyze 3D structures of RhD caused by the variant alleles. The effect of non-synonymous substitutions was predicted using Polymorphism Phenotyping algorithm (PolyPhen-2), Sorting Intolerant From Tolerant (SIFT), and Protein Variation Effect Analyzer (PROVEAN) software.ResultsIn the collected RhD variants, 28 distinct RHD variant alleles were identified, including three novel variant alleles. RH-MLPA assay is advantageous for determining the copy number of RHD gene. 3D homology modeling predicted that protein conformation was disrupted and may explain RhD epitope differential expression. A total of 14 non-synonymous mutations were determined to be detrimental to the protein structure.DiscussionWe revealed the diversity of RHD alleles present in eastern Chinese RhD variants. The bioinformatics of these variant alleles extended our knowledge of RhD variants, which was crucial for evaluating their impact to guide transfusion support and avoid immune-related blood transfusion reactions.
Influence of Persistent Inflammation in Follow-Up Biopsies After Antibody-Mediated Rejection in Kidney Transplantation
Authors: Piñeiro Gaston J. , Montagud-Marrahi Enrique , Ríos José , Ventura-Aguiar Pedro , Cucchiari David , Revuelta Ignacio , Lozano Miquel , Cid Joan , Cofan Frederic , Esforzado Nuria , Palou Eduard , Oppenheimer Federico , Campistol Josep M. , Bayés-Genís Beatriu , Rovira Jordi , Diekmann Fritz 
Published: November 2021

Background: Despite recent advances in immunosuppression treatment, antibody-mediated rejection (ABMR) remains the leading cause of kidney graft loss. Information about prognostic markers and the efficacy of treatment is scarce.Methods: Retrospective study with kidney recipients diagnosed an active ABMR from January 1, 2004 to December 31, 2019 to explore the influence of persistent inflammation in follow-up biopsies on graft survival after ABMR treatment.Results: About 116 patients were included. Active ABMR were treated with a combination of plasma exchange (PE), intravenous immunoglobulin (IVIg), rituximab, and steroids. At 6 months of treatment, 63 (54.3%) patients presented a stabilization or improvement in kidney-graft function. The effectiveness varied depending on the timepoint of the presentation between transplantation and rejection, which is lower for those with late ABMR (63 vs. 21% for early vs. late ABMR, respectively). Ninety patients (77%) underwent a control biopsy after ABMR treatment, from which 46 (51%) responded to the treatment. Microvascular inflammation (MVI) persisted in 64 (71%) biopsies, whereas tubulitis persisted in 17 (19%) biopsies. Death-censored graft survival at 1 year was significantly lower in patients with persistent MVI (86% vs. 95% without persistent MVI, P = 0.002), or with persistent tubulitis (44% vs. 66% without tubulitis, P = 0.02). In the Cox Regression analysis, the persistence of MVI [hazard ratio (HR), 4.50 (95%CI, 1.35–14.96), P = 0.01] and tubulitis [HR 2.88 95%CI (1.24–6.69), P = 0.01) in follow-up biopsies significantly increased the risk of graft failure.Conclusion: Persistent inflammation in follow-up biopsies after ABMR treatment was associated with an increased risk of graft loss, even without meeting Banff rejection criteria.Study Registration: Agencia Española de Medicamentos y Productos Sanitarios (AEMPS): 14566/RG 24161. Study code: UTRINM-2017-01.