bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging thewater‐energynexus to derive benefits for the electric grid throughdemand‐sidemanagement in the water supply and wastewater sectors
Authors: Zohrabian Angineh , Plata Sophia L. , Kim Dong Min , Childress Amy E. , Sanders Kelly T. 
Published: March 2021

AbstractLeveraging the potential flexibility of large electrical loads has become an attractive option for maintaining grid reliability, especially in electric grids with high penetrations of variable renewable energy. The water sector is a particularly attractive option for demand‐side flexibility due to its vast water storage infrastructure, large interruptible pumping loads, and energy generation opportunities. Shifting the timing of water supply and wastewater utility operations can reduce peak load and temporally align energy‐consuming activities with periods of cheap electricity prices and/or high renewable energy generation. This paper presents a general overview of demand‐side management strategies in water and wastewater systems, focusing primarily on demand‐response measures. We find that while there is consensus in the literature about the potential for water systems to provide flexible demand‐side management services, there is a need for developing comprehensive water‐energy models to examine the value of load management as a source of revenue for water utilities and as a source of flexibility for the electric grid. More experimental studies and simulation efforts are also needed to address the technical complexities and water quality concerns associated with interrupting water and wastewater utility operations.This article is categorized under:Engineering Water > Sustainable Engineering of WaterEngineering Water > Planning Water
Point‐of‐critical‐care diagnostics for sepsis enabled by multiplexed micro and nanosensing technologies
Authors: Ashley Brandon K. , Hassan Umer 
Published: March 2021

AbstractSepsis is responsible for the highest economic and mortality burden in critical care settings around the world, prompting the World Health Organization in 2018 to designate it as a global health priority. Despite its high universal prevalence and mortality rate, a disproportionately low amount of sponsored research funding is directed toward diagnosis and treatment of sepsis, when early treatment has been shown to significantly improve survival. Additionally, current technologies and methods are inadequate to provide an accurate and timely diagnosis of septic patients in multiple clinical environments. For improved patient outcomes, a comprehensive immunological evaluation is critical which is comprised of both traditional testing and quantifying recently proposed biomarkers for sepsis. There is an urgent need to develop novel point‐of‐care, low‐cost systems which can accurately stratify patients. These point‐of‐critical‐care sensors should adopt a multiplexed approach utilizing multimodal sensing for heterogenous biomarker detection. For effective multiplexing, the sensors must satisfy criteria including rapid sample to result delivery, low sample volumes for clinical sample sparring, and reduced costs per test. A compendium of currently developed multiplexed micro and nano (M/N)‐based diagnostic technologies for potential applications toward sepsis are presented. We have also explored the various biomarkers targeted for sepsis including immune cell morphology changes, circulating proteins, small molecules, and presence of infectious pathogens. An overview of different M/N detection mechanisms are also provided, along with recent advances in related nanotechnologies which have shown improved patient outcomes and perspectives on what future successful technologies may encompass.This article is categorized under:
Diagnostic Tools > Biosensing
Non-local approximation of the Griffith functional
Authors: Scilla Giovanni , Solombrino Francesco 
Published: March 2021

AbstractAn approximation, in the sense of$$\Gamma $$Γ-convergence and in any dimension$$d\ge 1$$d≥1, of Griffith-type functionals, withp-growth ($$p>1$$p>1) in the symmetrized gradient, is provided by means of a sequence of non-local integral functionals depending on the average of the symmetrized gradients on small balls.
Stationary characters on lattices of semisimple Lie groups
Authors: Boutonnet Rémi , Houdayer Cyril 
Published: March 2021

AbstractWe show that stationary characters on irreducible lattices$\Gamma < G$Γ<Gof higher-rank connected semisimple Lie groups are conjugation invariant, that is, they are genuine characters. This result has several applications in representation theory, operator algebras, ergodic theory and topological dynamics. In particular, we show that for any such irreducible lattice$\Gamma < G$Γ<G, the left regular representation$\lambda _{\Gamma }$λΓis weakly contained in any weakly mixing representation$\pi $π. We prove that for any such irreducible lattice$\Gamma < G$Γ<G, any Uniformly Recurrent Subgroup (URS) of$\Gamma $Γis finite, answering a question of Glasner–Weiss. We also obtain a new proof of Peterson’s character rigidity result for irreducible lattices$\Gamma < G$Γ<G. The main novelty of our paper is a structure theorem for stationary actions of lattices on von Neumann algebras.
Mechanical model of steel frames with reinforced concrete infill walls
Authors: Morelli Francesco , Panzera Ivan , Salvatore Walter 
Published: March 2021

AbstractThis paper presents a mechanical model developed for the simulation of the monotonic behaviour of Steel frames with Reinforced Concrete infill Walls (SRCW). In particular, it deals with a specific typology of SRCW, obtained from the classical one through the interposition of dissipative elements in the columns and by stiffening and shaping the steel frame’s corners in a way to prevent the brittle failure of the concrete in compression. This system has demonstrated in past researches to be able to overcome the typical problems of SRCWs and to assure, through a capacity design approach, a global ductile behavior. The selection of the main components to be included in the model is carried out on the base of the analysis of the available experimental tests and of the results of accurate 3D Finite Element model analyses. The behaviour of each component is represented though consolidated models present in the current state-of-the-art and, where necessary, calibrated using the results of the experimental and numerical analyses. The capacity of the proposed mechanical model in representing the global behaviour of the SRCWs is finally demonstrated comparing the results in terms of force–displacement curves with the ones obtained through the refined 3D Finite Element models.
Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery
Authors: Almeida Carlos A. , Torres-Espin Abel , Huie J. Russell , Sun Dongming , Noble-Haeusslein Linda J. , Young Wise , Beattie Michael S. , Bresnahan Jacqueline C. , Nielson Jessica L. , Ferguson Adam R. 
Published: March 2021

AbstractMeta-analyses suggest that the published literature represents only a small minority of the total data collected in biomedical research, with most becoming ‘dark data’ unreported in the literature. Dark data is due to publication bias toward novel results that confirm investigator hypotheses and omission of data that do not. Publication bias contributes to scientific irreproducibility and failures in bench-to-bedside translation. Sharing dark data by making it Findable, Accessible, Interoperable, and Reusable (FAIR) may reduce the burden of irreproducible science by increasing transparency and support data-driven discoveries beyond the lifecycle of the original study. We illustrate feasibility of dark data sharing by recovering original raw data from the Multicenter Animal Spinal Cord Injury Study (MASCIS), an NIH-funded multi-site preclinical drug trial conducted in the 1990s that tested efficacy of several therapies after a spinal cord injury (SCI). The original drug treatments did not produce clear positive results and MASCIS data were stored in boxes for more than two decades. The goal of the present study was to independently confirm published machine learning findings that perioperative blood pressure is a major predictor of SCI neuromotor outcome (Nielson et al., 2015). We recovered, digitized, and curated the data from 1125 rats from MASCIS. Analyses indicated that high perioperative blood pressure at the time of SCI is associated with poorer health and worse neuromotor outcomes in more severe SCI, whereas low perioperative blood pressure is associated with poorer health and worse neuromotor outcome in moderate SCI. These findings confirm and expand prior results that a narrow window of blood-pressure control optimizes outcome, and demonstrate the value of recovering dark data for assessing reproducibility of findings with implications for precision therapeutic approaches.
Estimation of thermal time model parameters for seed germination in 15 species: the importance of distribution function
Authors: Chen Dali , Chen Xianglai , Wang Jingjing , Zhang Zuxin , Wang Yan , Jia Cunzhi , Hu Xiaowen 
Published: March 2021

AbstractThermal time models have been widely applied to predict temperature requirements for seed germination. Generally, a log-normal distribution for thermal time [θT(g)] is used in such models at suboptimal temperatures to examine the variation in time to germination arising from variation in θT(g) within a seed population. Recently, additional distribution functions have been used in thermal time models to predict seed germination dynamics. However, the most suitable kind of the distribution function to use in thermal time models, especially at suboptimal temperatures, has not been determined. Five distributions (log-normal, Gumbel, logistic, Weibull and log-logistic) were used in thermal time models over a range of temperatures to fit the germination data for 15 species. The results showed that a more flexible model with the log-logistic distribution, rather than the log-normal distribution, provided the best explanation of θT(g) variation in 13 species at suboptimal temperatures. Thus, at least at suboptimal temperatures, the log-logistic distribution is an appropriate candidate among the five distributions used in this study. Therefore, the distribution of parameters [θT(g)] should be considered when using thermal time models to prevent large deviations; furthermore, an appropriate equation should be selected before using such a model to make predictions.
Left ventricular longitudinal strain and strain rate measurements in paediatric patients in long-term treatment for Chagas disease
Authors: Goldsman Alejandro , Vazquez Haydee , Quilindro Alberto , Sicurello María , Cazalas Mariana , Altcheh Jaime , González Nicolás , Moros Claudio , Grippo María 
Published: March 2021

AbstractIntroduction:Previous echocardiographic studies failed to show residual alterations of heart function in paediatric patients that have received treatment for Chagas disease. While the echocardiogram is the fundamental front-line tool for evaluating heart function, the appearance of new techniques allows a more detailed analysis. We aimed to evaluate systolic and diastolic function with new techniques in a paediatric population with Chagas disease several years after treatment completion.Material and methods:Echocardiograms were obtained from 84 Chagas disease patients (48 female) and 27 healthy controls. All patients had received treatment concluding on average 10 years prior to the study. The prospective analysis considered cardiac dimensions and cardiac function using two-dimensional, M-mode, Doppler and tissue Doppler imaging with emphasis on measuring longitudinal strain in the left ventricle by speckle tracking. Ejection fraction was measured with three-dimensional echocardiography.Results:Patients had an age of 14.2 ± 5.7 years (6–33) at the time of evaluation. Global and segmental motility of the left ventricle was normal in all patients. Ejection fraction was 59.2 ± 6.5 and 57.4 ± 6.5% (p = 0.31) in patients and controls respectively. Left ventricular global longitudinal systolic strain was −19 ± 2.4% in patients and −19 ± 3.6% (p = 0.91) in controls. No significant differences were found in remaining systolic and diastolic function measurements.Conclusions:Paediatric patients that have received treatment for Chagas disease, evaluated with either conventional techniques or new tools, do not show significant long-term alterations of ventricular function.
Navigating the terrain of moral distress: Experiences of pediatric end-of-life care and bereavement during COVID-19
Authors: Wiener Lori , Rosenberg Abby R. , Pennarola Brian , Fry Abigail , Weaver Meaghann 
Published: March 2021

AbstractObjectiveParents of seriously ill children worry about their vulnerable child contracting COVID-19, whether their child's palliative care providers will be able to continue to provide the same quality of care to their child, and who can be with the child to provide comfort. For providers, shifts in healthcare provision, communication formats, and support offerings for families facing distress or loss during the pandemic may promote providers’ moral distress. This study aimed to define the ways that the COVID-19 pandemic has impacted end-of-life care and approach to bereavement care in pediatric palliative care (PPC).MethodThe Palliative Assessment of Needed DEvelopments and Modifications In the Era of Coronavirus (PANDEMIC) survey was developed to learn about the PPC experience during COVID-19 in the United States. The survey was posted with permission on seven nationally focused Listservs.ResultsA total of 207 PPC team members from 80 cities within 39 states and the District of Columbia participated. In the majority of hospitals, admitted pediatric patients were only allowed one parent as a visitor with the exception of both parents or nuclear family at end of life. Creative alternatives to grief support and traditional funeral services were described. The high incidence of respondents’ depicted moral distress was often focused on an inability to provide a desired level of care due to existing rules and policies and bearing witness to patient and family suffering enhanced by the pandemic.Significance of resultsThe COVID-19 pandemic has had a profound impact on the provision of end-of-life care and bereavement for children, family caregivers, and PPC providers. Our results identify tangible limitations of restricted personal contact and the pain of watching families stumble through a stunted grieving process. It is imperative that we find solutions for future global challenges and to foster solidarity in PPC.
Prenatal and pubertal exposure to 17α-ethinylestradiol disrupts folliculogenesis and promotes morphophysiological changes in ovaries of old gerbils (Meriones unguiculatus)
Authors: de Souza Vinícius Gonçalves , Bandeira Laura Borges , Souza Nátaly Caroline Silva e , Taboga Sebastião Roberto , Martins Tracy Martina Marques , Silva Perez Ana Paula 
Published: March 2021

Abstract17α-Ethinylestradiol is an endocrine-disrupting chemical that make up most contraceptive pills and can be found in the environment. Exposure to ethinylestradiol in different development periods may promote changes in morphophysiological parameters of reproductive and endocrine organs. Considering that the effects of low doses (15 µg/kg/day) of ethinylestradiol in ovaries from 12-month-old female gerbils (Meriones unguiculatus) were investigated. Four experimental groups used were control (without treatment), EE/PRE (treated from the 18th to the 22nd gestational day), EE/PUB (treated from the 42nd to the 49th day of life), and EE/PRE-PUB (treated in the both periods). The animals were euthanized at 12 months. Testosterone and 17β-estradiol levels were measured. The ovaries were stained with Hematoxylin and Eosin, Periodic Acid Schiff, and Gomori’s Trichome. The follicles, corpus luteum, interstitial gland, lipofuscin, ovarian epithelium, and tunica albuginea were analyzed. Estradiol was higher in EE/PRE and EE/PUB groups, while testosterone was higher only in EE/PUB group. The main changes in follicle count occurred in EE/PUB and EE/PRE-PUB groups, with higher primordial follicle count and lower maturation of follicles. The corpus luteum was more evident in EE/PRE group. No differences were found in atretic follicles count. A higher area occupied by interstitial gland cells and lipofuscin deposit in these cells was noted in EE/PUB and EE/PRE-PUB groups. Higher epithelium height and thicker tunic albuginea were showed in treated groups. These results suggest that exposure to doses of EE2 in prenatal and pubertal periods of the development leads to morphological changes in senile ovaries.
The Effects of Cognitive Load on Strategy Utilization in a	Forced-Choice Recognition Memory Performance Validity Test
Authors: Omer Elad , Braw Yoram 
Published: March 2021

Abstract. Despite the importance of detecting feigned cognitive impairment, we have a limited understanding of the theoretical foundation of the phenomenon and the factors that affect it. Studies regarding the formation and implementation of feigning strategies during neuropsychological assessments are numbered, though there are indications that they tax cognitive resources. The current study assessed the effect of cognitive load manipulation on feigning strategies. To achieve this aim, we utilized a 2 × 2 experimental design; condition (simulators/honest responders) and cognitive load (load/no load) were manipulated while participants ( N = 154) performed a well-established performance validity test (PVT). The cognitive load manipulation reduced the quantity of feigning strategies, while also affecting their composition (i.e., strategies tended to be more intuitive). This suggests that reduced cognitive resources among those feigning cognitive impairment may impact the use of in-vivo feigning strategies. These findings, though preliminary, will hopefully encourage further research that will uncover the cognitive factors involved in the utilization of feigning strategies in neuropsychological assessments.
Clinical significance of increased arterial stiffness associated with atrial fibrillation, according to Framingham risk score
Authors: Chung Goh Eun , Park Hyo Eun , Lee Heesun , Choi Su-Yeon 
Published: March 2021

AbstractAtrial fibrillation (AF) is the most common arrhythmia in the elderly. Arterial stiffness may predict the risk of AF, but this relationship has not been fully evaluated. We assessed the association between arterial stiffness and prevalent AF. All subjects who had electrocardiography performed and a cardio-ankle vascular index (CAVI) calculated during a screening examination between 2010 and 2019 were enrolled. To evaluate the association between increased arterial stiffness and AF, we divided the population according to their Framingham risk score (FRS) into low-, intermediate-, and high-risk groups. A total of 8048 subjects were evaluated. The multivariate analysis revealed that increased arterial stiffness was significantly associated with AF prevalence, even after adjusting cardiovascular risk factors [odds ratio (OR) 1.685, 95% confidence interval (CI) 1.908–2.588, p = 0.017]. When we subcategorized the subjects according to their FRS, increased arterial stiffness was significantly associated with AF in the intermediate- and high-risk groups (OR 3.062, 95% CI 1.39-6.740 and OR3.877, 95% CI 1.142-13.167, respectively, BMI adjusted. High arterial stiffness shows a significant association with AF in those with intermediate or high cardiovascular risk, and can be used for further risk stratification of patients.
Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo
Authors: Ichijo Sadamitsu , Shindo Tomohiko , Eguchi Kumiko , Monma Yuto , Nakata Takashi , Morisue Yoshihiko , Kanai Hiroshi , Osumi Noriko , Yasuda Satoshi , Shimokawa Hiroaki 
Published: March 2021

AbstractSince the treatment window of thrombolytic therapy for stroke is limited, new therapy remains to be developed. We have recently developed low-intensity pulsed ultrasound (LIPUS) therapy to improve cognitive dysfunction in mouse models of vascular dementia and Alzheimer’s disease. Here, we further aimed to examine whether our LIPUS therapy improves neurological recovery from ischemic stroke, and if so, to elucidate the mechanisms involved. In a mouse model of middle cerebral artery occlusion (MCAO), we applied LIPUS (32 cycles, 193 mW/cm2) to the whole brain 3 times in the first week (days 1, 3, and 5) after MCAO. We evaluated neurological functions using behavioral tests and performed histological analyses. Furthermore, to elucidate how LIPUS works within the injured brain, we also tested the effects of LIPUS in endothelial nitric oxide synthase (eNOS)-deficient (eNOS−/−) mice. In wild-type mice, the LIPUS therapy markedly improved neurological functions in the tightrope and rotarod tests at 28 days after MCAO. Histological analyses showed that the LIPUS therapy significantly increased the numbers of CD31-positive blood vessels in the perifocal lesion and doublecortin (DCX)-positive neurons in the ischemic striatum, indicating the angio-neurogenesis effects of the therapy. Importantly, these beneficial effects of the LIPUS therapy were totally absent in eNOS−/− mice. No adverse effects of the LIPUS therapy were noted. These results indicate that the LIPUS therapy improves neurological functions after stroke through enhanced neuro-angiogenesis in mice in vivo in an eNOS-dependent manner, suggesting that it could a novel and non-invasive therapeutic option for stroke.
Socioeconomic inequalities in children’s weight, height and BMI trajectories in Norway
Authors: Mekonnen Teferi , Papadopoulou Eleni , Arah Onyebuchi A. , Brantsæter Anne Lise , Lien Nanna , Gebremariam Mekdes K. 
Published: March 2021

AbstractStudies exploring when social inequalities in body mass index (BMI) and its composites emerge and how these evolve with age are limited. Thus, this study explored parental income and education related inequalities in children’s weight, height, weight velocity and body mass index among Norwegian children from 1 month to 8 years. The study population included 59,927 family/children pairs participating in the Norwegian Mother, Father, and Child Cohort Study. Growth was modelled using the Jenss–Bayley model and linear mixed effects analyses were conducted. Maternal and paternal educational differences in children’s weight and BMI trajectories emerged during infancy, continuing to age 8 years. Parental income-related inequalities in children’s weight were observed from the age of 1 month to 4 years for maternal and up to 1 year for paternal income-related differences but then disappeared. Parental income-related inequalities in child’s BMI were observed from 18 months to 8 years for maternal income, and from 9 months to 8 years for paternal income-related differences. These results suggest that social inequalities in children’s BMI present early in infancy and continue to 8 years of age. The inequalities sometimes differed by indicator of socioeconomic position used. Interventions to combat these inequalities early in life are, thus needed.