bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-appropriate feeding practices and their association with undernutrition among children aged 6–23 months in aspirational districts of India: a multinomial analysis
Authors: Pradhan Itishree , Kandapan Binayak , Pradhan Jalandhar 
Published: November 2021

Abstract‘Health and nutrition’ is one among the five areas covered by the Aspirational District Programme in India, which aims to achieve the Sustainable Development Goals (SDGs). The reduction of undernutrition in under-five children has remained a major focus of the SDGs, especially at the ages of 6–23 months as this affects child development. This study used National Family Health Survey 2015–16 data to examine appropriate feeding practices and their associations with undernutrition among children aged 6–23 months in the 124 aspirational districts of India. Multinomial logistic regression analysis was used to analyse the association between feeding practices and undernutrition, adjusting for covariates. A total of 13,851 children aged 6–23 months were included in the analysis. Child nutritional outcomes, and children receiving the recommended minimum dietary diversity (MDD), minimum meal frequency (MMF) and minimum acceptable diet (MAD), were poorer in the aspirational compared with non-aspirational districts. However, the proportions of children who continued to breastfed, i.e. currently breastfeeding and the proportion of children who were receiving appropriate breastfeeding, i.e. receiving complementary feeding, in addition to breast milk, were higher in the aspirational districts. Appropriate breastfeeding and MDD were found to be associated negatively with undernutrition. While the continuation of breastfeeding increased the odds of children being undernourished, appropriate breastfeeding lowered the odds. The significant predictors of undernourishment among the study children were the child being male, of higher birth order, older and of smaller than average birth size; mother’s lower educational level, mother’s lower BMI of mothers and being a teenage mother; and poor household drinking water, sanitation facilities and lower economic status. This study suggests that educating mothers, especially illiterate and poor mothers, about appropriate breastfeeding and dietary diversity could help prevent and reduce child undernutrition in the aspirational districts of India.
Phytohormone dynamics impact fatty acid and oil accumulation during soybean seed maturation
Authors: Nguyen Thien Q. , Kisiala Anna B. , Hai Nguyen Ngoc , Narine Suresh , Emery R. J. Neil 
Published: November 2021

AbstractFatty acid (FA) levels and profiles are vital for soybean oil quality, while cytokinins (CKs) and abscisic acid (ABA) are potent regulators of plant growth and development. Previous research suggested associations between FA biosynthesis and hormonal signalling networks; however, hormonal regulation of FA accumulation during soybean (Glycine max) seed maturation has never been measured. We analysed hormone and FA profiles obtained from HPLC-(ESI)-MS/MS and GC-FID screening during soybean seed maturation. A multilayered data processing approach, involving heat-maps, principal component analysis (PCA), correlation and multiregression models, suggested a strong relationship between hormone metabolism and FA/oil accumulation during seed maturation. Most strikingly, positive correlations were found between the levels of CK ribosides [transZeatin riboside (tZR), N6-isopentenyladenosine (iPR)] at the early stages of SM (R5-R6) and C18:0, C18:2 and oil content at the R8 stage. Moreover, multiple regression models revealed functional linkages between several CK derivatives and FA and oil content in mature seeds. To further test the significance of hormone regulation in FA metabolism, plants of two soybean accessions with contrasting hormone and FA profiles were sprayed with exogenous ABA and transZeatin (tZ) during the seed-filling period (R5-R6). Depending on the hormone type and concentration, these treatments distinctly modified biosynthesis of all tested FAs, except for C18:0. Most remarkably, tZ (50 nM) promoted production of C16:0, C18:1, C18:2, C18:3, and oil accumulation in maturing seeds. Overall, the results indicate impactful roles for ABA and CKs in FA accumulation during SM and represent a further step towards understanding FA biosynthesis, and potential improvements of soybean oil profiles.
Moses or Noah? A case of ‘potato-potahto’ when using a foreign language
Authors: Dhaene Sara , Dirix Nicolas , Marcke Hélène Van , Woumans Evy 
Published: November 2021

AbstractResearch among bilinguals suggests a foreign language effect for various tasks requiring a more systematic processing style. For instance, bilinguals seem less prone to heuristic reasoning when solving problem statements in their foreign (FL) as opposed to their native (NL) language. The present study aimed to determine whether such an effect might also be observed in the detection of semantic anomalies. Participants were presented NL and FL questions with and without anomalies while their eye movements were recorded. Overall, they failed to detect the anomaly in more than half of the trials. Furthermore, more illusions occurred for questions presented in the FL, indicating an FL disadvantage. Additionally, eye movement analyses suggested that reading patterns for anomalies are predominantly similar across languages. Our results therefore substantiate theories suggesting that FL use induces cognitive load, causing increased susceptibility to illusions due to partial semantic processing.
A MESHLESS LOCAL GALERKIN INTEGRAL EQUATION METHOD FOR SOLVING A TYPE OF DARBOUX PROBLEMS BASED ON RADIAL BASIS FUNCTIONS
Authors: ASSARI P. , ASADI-MEHREGAN F. , DEHGHAN M. 
Published: November 2021

AbstractThe main goal of this paper is to solve a class of Darboux problems by converting them into the two-dimensional nonlinear Volterra integral equation of the second kind. The scheme approximates the solution of these integral equations using the discrete Galerkin method together with local radial basis functions, which use a small set of data instead of all points in the solution domain. We also employ the Gauss–Legendre integration rule on the influence domains of shape functions to compute the local integrals appearing in the method. Since the scheme is constructed on a set of scattered points and does not require any background meshes, it is meshless. The error bound and the convergence rate of the presented method are provided. Some illustrative examples are included to show the validity and efficiency of the new technique. Furthermore, the results obtained demonstrate that this method uses much less computer memory than the method established using global radial basis functions.
Reply to Comment by Rigolot on “Narratives Behind Livestock Methane Mitigation Studies Matter”
Authors: Chang Jinfeng , Peng Shushi , Yin Yi , Ciais Philippe , Havlik Petr , Herrero Mario 
Published: November 2021

AbstractA comment by Dr. Rigolot acknowledged the scientific value of our recent study on livestock methane emissions and mitigation potentials, while highlighting that our study should better “cultivate synergies between production and more ambitious demand‐side efforts.” The author's comment questioned our narrative to be inadvertently (not intentionally) contributing to a “climate delay discourse” in several ways that might hinder ambitious mitigation efforts. This is indeed a welcome perspective that merits further comment.
Migration of Fluid‐Induced Seismicity Reveals the Seismogenic State of Faults
Authors: De Barros Louis , Wynants‐Morel Nicolas , Cappa Frédéric , Danré Philippe 
Published: November 2021

AbstractSeismic swarms, in natural contexts or induced by anthropogenic fluid injections, commonly show migrations of earthquake hypocenters. Classically, such migrations are interpreted as the diffusion of the fluid pressure. However, recent studies show that the seismic front maps the stress concentration at the tips of propagating aseismic slip that is primarily induced by the fluid pressure increase. In this case, seismic migration might depend on the hydromechanical properties that control the dynamics of aseismic slip propagation rather than the hydraulic diffusivity. Here, we use synthetic seismic catalogs obtained from the hydromechanical modeling of a slip‐weakening, permeable fault response to a fluid injection. By varying the fault permeability and the stress state, we show that the shape of the seismic front in a distance‐time plot depends on the initial fault criticality to failure, and not on the hydraulic properties. We then extrapolate this numerical result to seven observed injection‐induced earthquake swarms by showing that the shape of the migration front directly depends on the seismogenic index. The seismic front has a diffusive behavior when the aseismic slip is directly driven by the pressure increase, either at the swarm beginning or later if the faults are not initially critically stressed. On the contrary, an accelerating seismic front indicates a high‐criticality stressed fault, on which the aseismic slip runs away from the fluid pressurized area. Therefore, this study highlights that the seismic front shape may prove a useful indicator to characterize the initial stress state of faults over which the swarms occur.
What Causes the Unobserved Early‐Spring Snowpack Ablation in Convection‐Permitting WRF Modeling Over Utah Mountains?
Authors: He Cenlin , Chen Fei , Abolafia‐Rosenzweig Ronnie , Ikeda Kyoko , Liu Changhai , Rasmussen Roy 
Published: November 2021

AbstractAccurate prediction of snowpack evolution and ablation is critical to supporting weather and hydrological applications. Convection‐permitting modeling has been shown to well capture observed snowpack evolution over many western United States (U.S.) mountain ranges, but some significant ablation biases still remain. In this study, we conduct process‐level snowpack analyses of a widely used convection‐permitting (4‐km) weather research and forecasting (WRF) modeling product (WRF4km) for the contiguous U.S. to understand the mechanisms causing its unobserved early‐spring snow ablation over Utah mountains. Analyses across Utah Snowpack Telemetry (SNOTEL) sites show that the unobserved snowpack ablation during mid‐February to late‐March in WRF4km is driven by multiple strong melting events. The melting results from the enhanced downward sensible heat flux to snowpack and enhanced ground solar radiation absorption, with generally larger contributions from the former before early March and from the latter after early March. The enhanced downward sensible heat flux to snowpack is mainly due to the enhanced surface heat exchange coefficient induced by high surface wind speeds. The enhanced ground solar radiation absorption is driven by both enhanced surface downward solar radiation and strong melting‐induced snow cover reduction that is caused by deficiencies in Noah‐MP snow‐related parameterizations used in WRF4km. The substantial snow cover reduction during melting decreases surface albedo and hence triggers a positive albedo feedback that further accelerates melting. Our analyses reveal possible deficiencies in WRF and Noah‐MP (e.g., canopy processes and snow albedo) and shed light on future directions for model improvements.
Global‐Scale Ionospheric Tomography During the March 17, 2015 Geomagnetic Storm
Authors: Prol F. S. , Kodikara T. , Hoque M. M. , Borries C. 
Published: November 2021

AbstractThe correct representation of global‐scale electron density is crucial for monitoring and exploring the space weather. This study investigates whether the ground‐based Global Navigation Satellite System (GNSS) tomography can be used to reflect the global spatial and temporal responses of the ionosphere under storm conditions. A global tomography of the ionosphere electron density is constructed based on data from over 2,700 GNSS stations. In comparison to previous techniques, advances are made in spatial and temporal resolution, and in the assessment of results. To demonstrate the capabilities of the approach, the developed method is applied to the March 17, 2015 geomagnetic storm. The tomographic reconstructions show good agreement with electron density observations from worldwide ionosondes, Millstone Hill incoherent scatter radar and in‐situ measurements from satellite missions. Also, the results show that the tomographic technique is capable of reproducing plasma variabilities during geomagnetically disturbed periods including features such as equatorial ionization anomaly enhancements and depletion. Validation results of this brief study period show that the accuracy of our tomography is better than the Neustrelitz Electron Density Model, which is the model used as background, and physics‐based thermosphere‐ionosphere‐electrodynamics general circulation model. The results show that our tomography approach allows us to specify the global electron density from ground to ∼900 km accurately. Given the demonstrated quality, this global electron density reconstruction has potential for improving applications such as assessment of the effects of the electron density on radio signals, GNSS positioning, computation of ray tracing for radio‐signal transmission, and space weather monitoring.
Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
Authors: Sripada Chandra , Angstadt Mike , Taxali Aman , Kessler Daniel , Greathouse Tristan , Rutherford Saige , Clark D. Angus , Hyde Luke W. , Weigard Alex , Brislin Sarah J. , Hicks Brian , Heitzeg Mary 
Published: November 2021

AbstractConvergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks);pPERMUTATIONvalues < 0.05 FDR-corrected for multiple comparisons. Higher P factor scores were associated with hypoconnectivity within default network and hyperconnectivity between default network and multiple control networks. Among connections within these 28 significant cells, the P factor was predominantly associated with “attenuating” effects (67%;pPERMUTATION < 0.0002), i.e., reduced connectivity at neurotypically positive connections and increased connectivity at neurotypically negative connections. These results demonstrate that the general factor of psychopathology produces attenuating changes across multiple networks including default network, involved in spontaneous responses, and control networks involved in cognitive control. Moreover, they clarify mechanisms of transdiagnostic risk for psychopathology and invite further research into developmental causes of distributed attenuated connectivity.
Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells
Authors: Zhang Guoxi , Zou Junrong , Shi Jinglin , Qian Biao , Qiu Kaiyang , Liu Quanliang , Xie Tianpeng , He Zhihua , Xu Hui , Liao Yunfeng , Wu Yuting , Li Yanmin , Xiao Guancheng , Yuan Yuanhu , Xiao Rihai , Wu Gengqing , Zou Xiaofeng 
Published: November 2021

AbstractSmall ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinoma (ccRCC) is unclear. Therefore, we investigated the expression and function of UBA2 in ccRCC. Both mRNA and protein expression levels of UBA2 were found to be higher in ccRCC than in normal renal tissues and significantly related to the tumor size, Fuhrman grade, and tumor stage. UBA2 knockdown inhibited ccRCC cell growth, promoted apoptosis in vitro and in vivo, and decreased the abundance of a p53 mutant, c-Myc, and key enzymes of the SUMO modification system. Meanwhile, overexpression of UBA2 had the opposite effects. Overexpression of the p53 mutant or c-Myc alleviated the effects of UBA2 knockdown on ccRCC cell proliferation and apoptosis. In conclusion, targeting UBA2 may have a therapeutic potential against ccRCC.
PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer
Authors: Zhang Xin , Wang Kexin , Feng Xingbo , Wang Jian , Chu Yali , Jia Chunmeng , He Qingsi , Chen Cheng 
Published: November 2021

AbstractAbnormal angiogenesis occurs during the growth of solid tumors resulting in increased vascular permeability to fluids and metastatic cancer cells. Anti-angiogenesis therapy for solid tumors is effective in the treatment of cancer patients. However, the efficacy of anti-angiogenesis therapy is limited by drug resistance. The findings of the current study showed that HIF1α R282 is methylated by PRMT3, which is necessary for its stabilization and oncogene function. Analysis showed that PRMT3-mediated tumorigenesis is HIF1α methylation-dependent. A novel therapeutic molecule (MPG-peptide) was used to inhibit HIF1α expression. These findings provided information on PRMT3 signaling pathway and HIF1/VEGFA signaling pathway and offer a novel therapeutic strategy for colorectal cancer, mainly for treatment of anti-angiogenesis resistance patients.
Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway
Authors: Zhang Lin , Wei Wei , Ai Xiaoyu , Kilic Ertugrul , Hermann Dirk M. , Venkataramani Vivek , Bähr Mathias , Doeppner Thorsten R. 
Published: November 2021

AbstractSystemic transplantation of oxygen−glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. Herein, we analyzed whether or not extracellular vesicles (EVs) derived from such microglia are the biological mediators of these observations and which signaling pathways are involved in the process. Exposing bEnd.3 endothelial cells (ECs) and primary cortical neurons to OGD, the impact of EVs from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed. Under these conditions, EV treatment stimulated both angiogenesis and tube formation in ECs and repressed neuronal cell injury. Characterizing microglia EVs by means of Western blot analysis and other techniques revealed these EVs to be rich in TGF-β1. The latter turned out to be a key compound for the therapeutic potential of microglia EVs, affecting the Smad2/3 pathway in both ECs and neurons. EV infusion in stroke mice confirmed the aforementioned in vitro results, demonstrating an activation of the TGF-β/Smad2/3 signaling pathway within the ischemic brain. Furthermore, enriched TGF-β1 in EVs secreted from OGD-preconditioned microglia stimulated M2 polarization of residing microglia within the ischemic cerebral environment, which may contribute to a regulation of an early inflammatory response in postischemic hemispheres. These observations are not only interesting from the mechanistic point of view but have an immediate therapeutic implication as well, since stroke mice treated with such EVs displayed a better functional recovery in the behavioral test analyses. Hence, the present findings suggest a new way of action of EVs derived from OGD-preconditioned microglia by regulating the TGF-β/Smad2/3 pathway in order to promote tissue regeneration and neurological recovery in stroke mice.
rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
Authors: Yu Hua , Sun Zhen , Tan Tianyu , Pan Hongru , Zhao Jing , Zhang Ling , Chen Jiayu , Lei Anhua , Zhu Yuqing , Chen Lang , Xu Yuyan , Liu Yaxin , Chen Ming , Sheng Jinghao , Xu Zhengping , Qian Pengxu , Li Cheng , Gao Shaorong , Daley George Q. , Zhang Jin 
Published: November 2021

AbstractThe nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA biogenesis can drive the 2-cell stage embryo-like (2C-like) program and induce an expanded 2C-like cell population in mouse embryonic stem (mES) cells. Mechanistically, nucleolar integrity maintains normal liquid-liquid phase separation (LLPS) of the nucleolus and the formation of peri-nucleolar heterochromatin (PNH). Upon defects in rRNA biogenesis, the natural state of nucleolus LLPS is disrupted, causing dissociation of the NCL/TRIM28 complex from PNH and changes in epigenetic state and reorganization of the 3D structure of PNH, which leads to release of Dux, a 2C program transcription factor, from PNH to activate a 2C-like program. Correspondingly, embryos with rRNA biogenesis defect are unable to develop from 2-cell (2C) to 4-cell embryos, with delayed repression of 2C/ERV genes and a transcriptome skewed toward earlier cleavage embryo signatures. Our results highlight that rRNA-mediated nucleolar integrity and 3D structure reshaping of the PNH compartment regulates the fate transition of mES cells to 2C-like cells, and that rRNA biogenesis is a critical regulator during the 2-cell to 4-cell transition of murine pre-implantation embryo development.
Ultrasound-activated ciliary bands for microrobotic systems inspired by starfish
Authors: Dillinger Cornel , Nama Nitesh , Ahmed Daniel 
Published: November 2021

AbstractCilia are short, hair-like appendages ubiquitous in various biological systems, which have evolved to manipulate and gather food in liquids at regimes where viscosity dominates inertia. Inspired by these natural systems, synthetic cilia have been developed and utilized in microfluidics and microrobotics to achieve functionalities such as propulsion, liquid pumping and mixing, and particle manipulation. Here, we demonstrate ultrasound-activated synthetic ciliary bands that mimic the natural arrangements of ciliary bands on the surface of starfish larva. Our system leverages nonlinear acoustics at microscales to drive bulk fluid motion via acoustically actuated small-amplitude oscillations of synthetic cilia. By arranging the planar ciliary bands angled towards (+) or away (−) from each other, we achieve bulk fluid motion akin to a flow source or sink. We further combine these flow characteristics with a physical principle to circumvent the scallop theorem and realize acoustic-based propulsion at microscales. Finally, inspired by the feeding mechanism of a starfish larva, we demonstrate an analogous microparticle trap by arranging + and − ciliary bands adjacent to each other.