bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Knowledge Affect the Attitude of Fertile Aged Women in Visual Inspection with Acetic Acid Examination? A cross-sectional study
Authors: Hanudji Christy , Suparman Eddy , Sondakh Joice M. M. 
Published: April 2021

Objective: To find out the relationship between knowledge and attitudes of fertile aged women with IVA examination behaviour at Bitung Barat Public Health Center in Bitung City.Method: This was a cross-sectional study. Samples of 145 fertile aged women in area Bitung Barat Public Health Center Bitung city.Results: Of the 145 respondents, the highest group had sufficient and good knowledge. The highest percentage is respondents who have sufficient knowledge with a percentage of 44.14%. The attitude towards the IVA examination was assessed as good as 122 people (84.14%). The number of respondents who did not do an IVA examination is 94 people (64.83%) more than respondents who did not do an IVA examination that is 51 people (35.17%). Based on the results of statistical tests it is known that the significance value of p = 0.000. The attitude of women of childbearing age is good then the behaviour of IVA examination is also good with the results of statistical tests known that the significance value p = 0.001.Conclusions: Respondents with good IVA examination behaviour have good knowledge and attitude.Keywords: attitude, behaviour, IVA examination, knowledge.
Abstrak
Tujuan: Mengetahui hubungan antara pengetahuan dan sikap perempuan usia subur dengan perilaku pemeriksaan IVA di Puskesmas Bitung Barat Kota Bitung.Metode: Metode penelitian berupa analitik observasional dengan rencangan potong lintang. Sampel sebesar 145 perempuan usia subur di wilayah Puskemas Bitung Barat Kota Bitung.Hasil: Dari 145 responden, kelompok tertinggi memiliki pengetahuan yang cukup dan baik. Persentase tertinggi yaitu responden yang memiliki pengetahuan cukup dengan persentase 44,14%. Sikap terhadap pemeriksaan IVA dinilai baik yaitu sebanyak 122 orang (84,14%). Jumlah responden yang tidak melakukan pemeriksaan IVA yaitu 94 orang (64,83%) lebih banyak dari responden yang tidak melakukan pemeriksaan IVA yaitu 51 orang(35,17%). Berdasarkan hasil uji statistik diketahui bahwa nilai signifikansi p= 0,000. Sikap perempuan usia subur yang baik maka perilaku pemeriksaan IVA juga baik dengan hasil uji statistik diketahui bahwa nilai signifikansi p= 0,001.Kesimpulan: Responden dangan perilaku pemeriksaan IVA yang baik memiliki pengetahuan dan sikap yang baik.Kata kunci: pengetahuan, pemeriksaan IVA, perilaku, sikap..
Anemia in Pregnancy as a Predisposing Factor of Severe Preeclampsia
Authors: Nugraha Gagah B.A. , Prasetyo Prakosa J. , Daliman  
Published: April 2021

Abstract
Objective: This case may partly explain that anaemia can be a predisposing factor for the development of many women with preeclampsia were have a low level of haemoglobin during their pregnancy.Methods: A case reportCase: We present a case 23-year-old pregnant woman who has had moderate anaemia with severe preeclampsia at 38-week pregnant. As the evidence, there were elevated blood pressure, decreasing haemoglobin obtained by routine blood analysis, and presence of urine protein by urinalysis examination.Conclusion: In terms of anaemia as one of a predisposing factor of preeclampsia it is important to care provider, pregnant women, and families to prevent anaemia in pregnancy through routine ANC.Keywords: anaemia, pregnancy, severe preeclampsia.

Abstrak
Tujuan: Kasus ini sebagian dapat menjelaskan bahwa anemia dapat menjadi faktor predisposisi bagi perkembangan banyak perempuan dengan preeklamsia yang memiliki kadar hemoglobin yang rendah selama masa kehamilan mereka.Metode: Laporan kasus.Kasus : Kami melaporan kasus ibu hamil berusia 23 tahun yang mengalami anemia sedang dengan preeklamsia berat di usia 38 minggu, dibuktikan dari peningkatan tekanan darah, penurunan hemoglobin, serta protein uria pada pemeriksaan urinalisis.Kesimpulan : Berkaitan antara anemia sebagai predisposisi preekalmsia, penting bagi petugas kesehatan dan ibu hamil serta keluarga untuk mencegah anemia dalam kehamilan melalui ANC yang rutin.Kata kunci : anemia, kehamilan, preeklamsia berat.
Premature ejaculation among post-coronary artery stenting patients attending cardiology out patient department of tertiary care hospitals
Authors: Faruque Shahriar , Biplob Salahuddin Qusar , Sarkar Mekhala , Farzana Nafia , Rahman Wasima , Zohra Fatima , Sajib Mohammad Waliul Hasnat 
Published: April 2021

Premature ejaculation (PE) is the most frequent sexual complaint of men. It may develop not only due to psychiatric disorders but also due to many chronic organic illnesses. Coronary artery stenting is an invasive procedure to manage coronary artery disease which is one of the leading chronic illnesses all over the world. Patients who survive from coronary artery diseases by getting invasive cardiac procedures, often develop reduced sexual function. The aim of the study was to identify the frequency of premature ejaculation among post coronary artery stenting patients. This was a descriptive, cross sectional study conducted in cardiology outpatient department (OPD) of Bangabandhu Sheikh Mujib Medical University (BSMMU) and cardiology OPD of National Institute of Cardiovascular Diseases (NICVD) from October 2017 to September 2018. 153 patients were selected purposively. After taking written consent a predetermined questionnaire containing 11 socio-demographic variables was filled for each patient through face to face interview. After that PEDT bangle version was applied.37.25% post coronary artery stenting male scored 11 or more and were identified as highly suggestive to have PE. Among the socio-demographic variables, Regular exercise, amount of sleep per day, smoking and history of chronic physical illness were found to be significantly associated with PE among post coronary artery stenting patients. The study showed that the patients who practiced a disciplined and healthy lifestyle were not in risk. The research findings may help us for the early diagnosis and better treatment plan to reduce patient sufferings.
Bang J Psychiatry June 2018; 32(1): 9-13
Uso de métodos não farmacológicos de alívio da dor durante o trabalho de parto e sua relação com a redução de ansiedade puerperal em uma maternidade da Rede SUS de Aracaju
Authors: Souza Luana Rocha de , Faria Felipe Silveira de , Almeida Larissa Wábia Santana de , Santos Letícia Andrade , Barreto Manuela Naiane Lima , Leite Débora Cristina Fontes 
Published: April 2021

Este trabalho objetiva avaliar o impacto entre o uso de métodos não-farmacológicos de alívio da dor durante o parto e ansiedade puerperal na Maternidade de Risco Habitual, em Aracaju, verificando a frequência do uso destas técnicas e o nível de ansiedade das parturientes. Trata-se de estudo prospectivo, transversal, com abordagem quantitativa com 810 puérperas, de todas as idades, advindas dos 75 municípios do estado de Sergipe que buscaram a maternidade da Rede SUS de Aracaju. De set./2019 a fev./2020, os pesquisadores coletaram dados dos prontuários de puérperas nas primeiras 48 horas após o parto, mediante Termo de Consentimento Livre e Esclarecido (TCLE) ou Termo de Assentimento Livre e Esclarecido (TALE). Avaliou-se se as parturientes utilizaram métodos não farmacológicos de alívio da dor e foram aplicados os questionários IDATE-Traço e IDATE-Estado para aferição de ansiedade nas puérperas. Analisou-se os dados coletados estatisticamente pelo programa Jasp versão 0.12.1. O CEP da Universidade Tiradentes aprovou o trabalho (parecer: 3.695.763). O estudo demonstrou correlação positiva (p-value < 0,05) entre métodos não farmacológicos de alívio de dor e IDATE-TRAÇO (SCORE) e IDATE-ESTADO (SCORE), em que mulheres com maior score para ansiedade não usaram métodos não farmacológicos de alívio da dor. Conclui-se haver relação estatística significativa entre métodos não farmacológicos de alívio da dor e ansiedade puerperal.
Hastanelerde Pasif Yangın Güvenlik Önlemlerinin Ulusal ve Uluslararası Mevzuatlara Göre Karşılaştırılması
Authors: ÇELİK Gülendam , YILDIZ Zehra 
Published: April 2021

Hastaneler, çalışan, öğrenci, hasta ve ziyaretçi sayısından dolayı kullanıcı yükü ve yangın yükü fazla olan kurumlardır. Hastanelerde, poliklinikler, derslikler, laboratuarlar, yemekhane, ofisler, mutfak, kazan dairesi, çatı katı, arşiv, elektrik tesisatı ve oksijen sistemleri gibi birçok mekân tek çatı altında toplandığı için çok tehlikeli işyerleri arasındadır. Bu yüzden hastanelerde yangın büyük bir risk olup, bina tasarımında önemli rol oynayan pasif sistemlere uygun dizayn edilmesi ile yangın riski ortadan kaldırılabilir ya da minimuma indirilebilir. Bu çalışmada, hastanelerde alınan pasif yangın güvenlik önlemleri hem ulusal hem uluslararası yangın güvenlik mevzuatlarına göre değerlendirilmiştir. Bu çalışmada, Türkiye yangından korunma yönetmeliği ile Amerika Bileşik Devletleri Standardı ve İngiliz Yapı Standardı gibi uluslararası yangın güvenlik mevzuatlarına göre hastanelerdeki pasif yangın güvenlik önlemleri 14 madde üzerinden karşılaştırılmıştır. Amerika Bileşik Devletleri Standardı olan NFPA yangın güvenlik önlemlerinde tüm maddeler detaylı olarak açıklanmıştır. Ancak diğer iki yönetmelik 14 maddeden sadece dört maddeye yer vermiştir. Hastanelerin alt bölümlerine ait özel hükümler bulunduğu için NFPA uluslararası standardından faydalanılarak ulusal mevzuatımızdaki pasif yangın güvenlik önlemlerindeki eksiklikler giderilirse hastane binalarındaki yangın riski en aza indirilebilecektir.
Pupillary Response to Postural Demand in Parkinson’s Disease
Authors: Kahya Melike , Lyons Kelly E. , Pahwa Rajesh , Akinwuntan Abiodun E. , He Jianghua , Devos Hannes 
Published: April 2021

Background:Individuals with Parkinson’s disease (PD) may need to spend more mental and physical effort (i.e., cognitive workload) to maintain postural control. Pupillary response reflects cognitive workload during postural control tasks in healthy controls but has not been investigated as a measure of postural demand in PD.Objectives:To compare pupillary response during increased postural demand using vision occlusion and dual tasking between individuals with PD and healthy controls.Methods:Thirty-three individuals with PD and thirty-five healthy controls were recruited. The four conditions lasted 60 s and involved single balance task with eyes open; single balance task with eyes occluded; dual task with eyes open; dual task with eyes occluded. The dual task comprised the Auditory Stroop test. Pupillary response was recorded using an eye tracker. The balance was assessed by using a force plate. Two-way Repeated Measures ANOVA and LSDpost-hoctests were employed to compare pupillary response and Center of Pressure (CoP) displacement across the four conditions and between individuals with PD and healthy controls.Results:Pupillary response was higher in individuals with PD compared to healthy controls (p= 0.009) and increased with more challenging postural conditions in both groups (p&lt; 0.001). Thepost-hocanalysis demonstrated increased pupillary response in the single balance eyes occluded (p&lt; 0.001), dual task eyes open (p= 0.01), and dual task eyes occluded (p&lt; 0.001) conditions compared to single task eyes open condition.Conclusion:Overall, the PD group had increased pupillary response with increased postural demand compared to the healthy controls. In the future, pupillary response can be a potential tool to understand the neurophysiological underpinnings of falls risk in the PD population.
Outcome of Patients With Metastatic Lung Neuroendocrine Tumors Submitted to First Line Monotherapy With Somatostatin Analogs
Authors: Lenotti Elisa , Alberti Andrea , Spada Francesca , Amoroso Vito , Maisonneuve Patrick , Grisanti Salvatore , Baggi Alice , Bianchi Susanna , Fazio Nicola , Berruti Alfredo 
Published: April 2021

ObjectiveAntiproliferative activity of somatostatin analogs (SSAs) has been demonstrated in digestive neuroendocrine tumors (NETs), but few data have been published in patients with pulmonary NETs. We therefore conducted a retrospective study to provide additional data on the outcome of patients with metastatic lung NETs submitted to front line SSAs.Research Design and MethodsPatients with metastatic lung NET treated with first line SSA-monotherapy (octreotide or lanreotide) in two different reference Institutions were reviewed. Outcome measures were progression-free survival (PFS) overall survival (OS), overall response rate and safety. We also explored prognostic factors associated with PFS.MethodsThe outcome of consecutive patients (pts) with metastatic lung NETs, who underwent first-line treatment with SSAs, recruited from 2014 on 2019 in two Italian reference Institutions, was retrospectively evaluated.ResultsThirty-one patients entered the study: 14 (45.2%) with typical and 17 (54.8%) atypical carcinoid. Six patients (19.4%) had a carcinoid syndrome. 60.0% of patients had Ki-67 ≤ 10%. Two (6.5%) patients obtained a partial response, 24 (77.4%) disease stabilization while 5 (16.1%) had progressive disease. Median progression free survival (PFS) was 28.6 months, median overall survival (OS) was not attained. Ki-67 ≤ 10%, typical carcinoid histotype and non-functioning disease, were associated with a non-significant PFS prolongation. PFS in patients with atypical carcinoids and in those with Ki-67 &gt;10% was greater than 19 months.ConclusionsThe long PFS and OS obtained in this case series suggest that SSAs could be effective as first line approach in the management of patients with progressive, metastatic pulmonary NET.
hsa-miR-33-5p as a Therapeutic Target Promotes Apoptosis of Breast Cancer Cells via Selenoprotein T
Authors: Zhuang Wei , Liu Jianhui , Li Wenjin 
Published: April 2021

Objective: Increasing evidence suggests that microRNA (miRNA) participates in regulating tumor cell apoptosis. We aimed to observe the effect of hsa-miR-33-5p on the apoptosis of breast cancer cells and to explore its regulatory relationship with selenoprotein T (SelT).Methods: RT-qPCR was used to examine the expression of hsa-miR-33-5p and SelT both in breast cancer tissues and cells. MCF-7 and MDA-MB-231 cells were transfected with hsa-miR-33-5p mimics or si-SelT. Then, a flow cytometry assay was carried out to examine the apoptosis of cells. Furthermore, SelT and apoptosis-related proteins including caspase-3, caspase-8, caspase-9, Bax, and Bcl-2 were detected via RT-qPCR and western blot. A luciferase reporter assay was utilized for assessing whether SelT was targeted by hsa-miR-33-5p.Results: Downregulated hsa-miR-33-5p was found both in breast cancer tissues and cells. After its overexpression, MCF-7 cell apoptosis was significantly promoted. Furthermore, our data showed that miR-33-5p elevated apoptosis-related protein expression in MCF-7 cells. Contrary to hsa-miR-33-5p, SelT was upregulated both in breast cancer tissues and cells. SelT expression was significantly inhibited by hsa-miR-33-5p overexpression. The luciferase reporter assay confirmed that SelT was a direct target of hsa-miR-33-5p. SelT overexpression could ameliorate the increase in apoptosis induced by hsa-miR-33-5p mimics.Conclusion: Our findings revealed that hsa-miR-33-5p, as a potential therapeutic target, could accelerate breast cancer cell apoptosis.
Lack of Opsonic Antibody Responses to Invasive Infections With Streptococcus dysgalactiae
Authors: Bläckberg Anna , de Neergaard Therese , Frick Inga-Maria , Nordenfelt Pontus , Lood Rolf , Rasmussen Magnus 
Published: April 2021

IntroductionStreptococcus dysgalactiae can cause severe recurrent infections. This study aimed to investigate antibody responses following S. dysgalactiae bacteraemia and possible development of protective immunity.Materials and MethodsPatients with S. dysgalactiae bacteraemia in the county of Skåne between 2017 and 2018 were prospectively included. Acute and convalescent sera were obtained. All isolates were emm typed and enzyme-linked immunosorbent assay (ELISA) was utilised to analyse specific antibody responses to bacteria and antigens. Bactericidal- and phagocytosis assays were applied to further establish antibody function.ResultsSixteen patients with S. dysgalactiae bacteraemia were included of whom one had recurrent episodes of bacteraemia. Using ELISA with S. dysgalactiae isolates and mutants, development of IgG antibodies was demonstrated in few patients. Type-specific antibodies were demonstrated in one patient when recombinant M proteins as antigens, were applied. The type-specific serum mediated a small increase in phagocytosis but did not facilitate increased killing of the S. dysgalactiae isolate, carrying that M protein, in blood or by phagocytic cells.ConclusionS. dysgalactiae bacteraemia sometimes results in increased levels of antibodies to the infecting pathogen. We did not find evidence that these antibodies are effectively opsonising. Apparent failure to produce opsonising antibodies might partially explain why S. dysgalactiae can cause recurrent invasive infections in the same host.
Deep Learning Based on ACR TI-RADS Can Improve the Differential Diagnosis of Thyroid Nodules
Authors: Wu Ge-Ge , Lv Wen-Zhi , Yin Rui , Xu Jian-Wei , Yan Yu-Jing , Chen Rui-Xue , Wang Jia-Yu , Zhang Bo , Cui Xin-Wu , Dietrich Christoph F. 
Published: April 2021

ObjectiveThe purpose of this study was to improve the differentiation between malignant and benign thyroid nodules using deep learning (DL) in category 4 and 5 based on the Thyroid Imaging Reporting and Data System (TI-RADS, TR) from the American College of Radiology (ACR).Design and MethodsFrom June 2, 2017 to April 23, 2019, 2082 thyroid ultrasound images from 1396 consecutive patients with confirmed pathology were retrospectively collected, of which 1289 nodules were category 4 (TR4) and 793 nodules were category 5 (TR5). Ninety percent of the B-mode ultrasound images were applied for training and validation, and the residual 10% and an independent external dataset for testing purpose by three different deep learning algorithms.ResultsIn the independent test set, the DL algorithm of best performance got an AUC of 0.904, 0.845, 0.829 in TR4, TR5, and TR4&amp;5, respectively. The sensitivity and specificity of the optimal model was 0.829, 0.831 on TR4, 0.846, 0.778 on TR5, 0.790, 0.779 on TR4&amp;5, versus the radiologists of 0.686 (P=0.108), 0.766 (P=0.101), 0.677 (P=0.211), 0.750 (P=0.128), and 0.680 (P=0.023), 0.761 (P=0.530), respectively.ConclusionsThe study demonstrated that DL could improve the differentiation of malignant from benign thyroid nodules and had significant potential for clinical application on TR4 and TR5.
MRI-Based Radiomics to Differentiate between Benign and Malignant Parotid Tumors With External Validation
Authors: Piludu Francesca , Marzi Simona , Ravanelli Marco , Pellini Raul , Covello Renato , Terrenato Irene , Farina Davide , Campora Riccardo , Ferrazzoli Valentina , Vidiri Antonello 
Published: April 2021

BackgroundThe differentiation between benign and malignant parotid lesions is crucial to defining the treatment plan, which highly depends on the tumor histology. We aimed to evaluate the role of MRI-based radiomics using both T2-weighted (T2-w) images and Apparent Diffusion Coefficient (ADC) maps in the differentiation of parotid lesions, in order to develop predictive models with an external validation cohort.Materials and MethodsA sample of 69 untreated parotid lesions was evaluated retrospectively, including 37 benign (of which 13 were Warthin’s tumors) and 32 malignant tumors. The patient population was divided into three groups: benign lesions (24 cases), Warthin’s lesions (13 cases), and malignant lesions (32 cases), which were compared in pairs. First- and second-order features were derived for each lesion. Margins and contrast enhancement patterns (CE) were qualitatively assessed. The model with the final feature set was achieved using the support vector machine binary classification algorithm.ResultsModels for discriminating between Warthin’s and malignant tumors, benign and Warthin’s tumors and benign and malignant tumors had an accuracy of 86.7%, 91.9% and 80.4%, respectively. After the feature selection process, four parameters for each model were used, including histogram-based features from ADC and T2-w images, shape-based features and types of margins and/or CE. Comparable accuracies were obtained after validation with the external cohort.ConclusionsRadiomic analysis of ADC, T2-w images, and qualitative scores evaluating margins and CE allowed us to obtain good to excellent diagnostic accuracies in differentiating parotid lesions, which were confirmed with an external validation cohort.
Preinvasive Colorectal Lesions of African Americans Display an Immunosuppressive Signature Compared to Caucasian Americans
Authors: Wallace Kristin , Nahhas Georges J. , Bookhout Christine , Lewin David N. , Paulos Chrystal M. , Nikolaishvili-Feinberg Nana , Cohen Stephanie M. , Guglietta Silvia , Bakhtiari Ali , Camp E. Ramsay , Hill Elizabeth G. , Baron John A. , Wu Jennifer D. , Alekseyenko Alexander V. 
Published: April 2021

BackgroundAfrican Americans (AAs) have higher colorectal cancer (CRC) incidence and mortality rate than Caucasian Americans (CAs). Recent studies suggest that immune responses within CRCs contribute to the disparities. If racially distinct immune signatures are present in the early phases of carcinogenesis, they could be used to develop interventions to prevent or slow disease.MethodsWe selected a convenience sample of 95 patients (48 CAs, 47 AAs) with preinvasive colorectal adenomas from the surgical pathology laboratory at the Medical University of South Carolina. Using immunofluorescent-conjugated antibodies on tissue slides from the lesions, we quantified specific immune cell populations: mast cells (CD117+), Th17 cells (CD4+RORC+), and NK cell ligand (MICA/B) and inflammatory cytokines, including IL-6, IL-17A, and IFN-γ. We compared the mean density counts (MDCs) and density rate ratios (RR) and 95% CI of immune markers between AAs to CAs using negative binomial regression analysis. We adjusted our models for age, sex, clinicopathologic characteristics (histology, location, dysplasia), and batch.ResultsWe observed no racial differences in age or sex at the baseline endoscopic exam. AAs compared to CAs had a higher prevalence of proximal adenomas (66% vs. 40%) and a lower prevalence of rectal adenomas (11% vs. 23%) (p =0.04) but no other differences in pathologic characteristics. In age, sex, and batch adjusted models, AAs vs. CAs had lower RRs for cells labeled with IFNγ (RR 0.50 (95% CI 0.32-0.81); p=0.004) and NK cell ligand (RR 0.67 (0.43-1.04); p=0.07). In models adjusted for age, sex, and clinicopathologic variables, AAs had reduced RRs relative to CAs for CD4 (p=0.02), NK cell ligands (p=0.01), Th17 (p=0.005), mast cells (p=0.04) and IFN-γ (p&lt; 0.0001).ConclusionsOverall, the lower RRs in AAs vs. CAs suggests reduced effector response capacity and an immunosuppressive (‘cold’) tumor environment. Our results also highlight the importance of colonic location of adenoma in influencing these differences; the reduced immune responses in AAs relative to CAs may indicate impaired immune surveillance in early carcinogenesis. Future studies are needed to understand the role of risk factors (such as obesity) in influencing differences in immune responses by race.