bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Intensif Danintegratif : Strategi Pengembangan Industri Kecil Menengah Produk Herbal di Kabupaten Badung
Authors: Wiagustini Ni Luh Putu 
Published: September 2021

Penelitianinibertujuanuntukmenganalisislingkungan internal dan lingkunganeksternalsertastrategi pengembangan Industri Kecil Menengah (IKM). Populasipenelitianiniadalahseluruh IKM Produk Herbal di KabupatenBadungyang merupakanProdukUnggulan di KabupatenBadung.jumlahIKM Produk Herbal di KabupatenBadungsebanyak 110 unit. Sampeldiambilsecarasensusatausampeljenuhyaituseluruhpopulasidijadikansampel. Data dianalisismenggunakanmetodeAnalisis SWOT (strenght, weakness, opportunity, treats) yang dituangkan dalam MatrikEksternal Factor Analysis Summary (EFAS) danMatrikInternal Factor Analysis Summary (IFAS). Penelitianinimenemukanbahwapengembangan IKM Produk Herbal di KabupatenBadungmelaluiStrategiIntensif dan Strategi Integratif yaitustrategi yang memerlukanusahaintensifuntukmeningkatkanposisidayasaing dan dayatarikproduk herbal KabupatenBadung yang meliputi : Strategipenetrasi pasar, Strategipengembanganproduk dan Strategi integratif.
Turnover Intention Karyawan: Pengaruh Budaya Organisasi, Organizational Justice dan Kepuasan Kerja
Authors: Noerchoidah Noerchoidah 
Published: September 2021

Tujuan dari penelitian ini adalah untuk menganalisis penerapan konsep turnover intention pada karyawan hotel di Surabaya-Indonesia, dengan difokuskan pada peran dari konstruk kepuasan kerja sebagai variabel mediatornya. Riset ini juga bertujuan untuk menganalisis pengaruh variabel budaya organisasi dan organizational justice pada kepuasan kerja, serta menganalisis pengaruh kepuasan kerja terhadap turnover intention. Penelitian ini dilakukan pada 152 karyawan hotel di Surabaya dengan purposive sampling. Hasil penyebaran kuesioner diolah dengan teknik analisis Partial Least Square (PLS). Terdapat 7 hipotesis yang diajukan dalam penelitian ini, sebanyak 6 hipotesis yang terdukung, yaitu H1, H2, H4, H5, H6, dan H7. Sementara H3 tidak terdukung. Hasil penelitian ini mendukung social exchange theory. Adapun kesimpulan holistik penelitian ini bahwa model penelitian ini didukung secara empiris.
The Role of Perceived Usefulness, Customer Satisfaction, and Emotional Stability, to Continuance Intention of C2c Online Shop in Surabaya
Authors: Danurwindo Muhammad Al Hakim , Anwar Muhadjir , Handayani Wiwik 
Published: September 2021

Fenomenon of C2C online shop which is currently in high demand by customers, has effect to the increasing with the amount an level of competition between companies. The purpose of this study is to examine the factors that can influence continuance intention of C2C online shop. The population in this study is consumer of C2C online shop in Surabaya city, and the research sample being C2C online consumers who have bought at least 1 transaction in a minimum period of 1 year purchased by 100 people. The method used in this study is a quantitative method, with PLS (Partial Least Square) analysis technique. The results showed that perceived usefulness and customer satisfaction has effect to the continuance shop intention. Perceived usefulness has effect to the customer satisfaction. Emotional stability has not effect in moderating perceived usefulness into the customer satisfaction. Customer satisfaction has effect tn mediating of the perceived usefulness into the continuance shop intention . The research implications show that continuance shop intention can increase customer purchase transactions at C2C online Shop.
Keyword: Continuance shop intention, Customer satisfaction, Perceived usefulness, Emotional stability, C2C Online shop
Nonobstructive azoospermia, when we can find spermatozoa, is FSH as a marker of succes?
Authors: Khelaia A. 
Published: September 2021

Azoospermia is the absence of spermatozoa in ejaculate even after semen centrifugation at least two times. Azoospermia due to spermatogenic failure – non-obstructive azoospermia (NOA) observed in 1% of population and in 10–15% of infertile men. Predictive factors for the presence of spermatozoa in testis are still under debate. The development of ICSI revolutionized management of azoospermia. In our practice we advised TESA as a first step and FSH can predict the success. According serum FSH levels we divided our men in three groups: FSH < 10 mU/ml, 10–15 mU/ml and > 15 mU/ml. We tried to evaluated SRR in accordance serum FSH level and find significant difference. In 117 men with FSH < 10 mU/ml SRR was 66% (in 77 cases), in 89 men which FSH was 10–15 mU/ml SRR was 27 % and finally SRR was 35% when FSH was > 15 mU/ml (45 cases from 131). At the same time, we make embryologist personal assessment (EPA) and try to show embryologist crucial role in tissue assessment after TESA. Another crucial point of discussion – histomorphology within the testis in NOA and indications for re – TESA after 3–6 months.
АКТУАЛЬНЫЕ АСПЕКТЫ СТАНДАРТИЗАЦИИ КОРНЕВИЩ И КОРНЕЙ РОДИОЛЫ РОЗОВОЙ
Authors: Куркин Владимир Александрович , Рязанова Татьяна Константиновна 
Published: September 2021

В работе обосновываются методологические подходы к анализу биологически активных соединений в корневищах и корнях родиолы розовой (Rhodiola rosea L.). С использованием метода ВЭЖХ разработана методика количественного определения розавина и салидрозида, являющихся доминирующими и диагностически значимыми биологически активными соединениями сырья данного растения.Определено, что содержание розавина в корневищах и корнях родиолы розовой варьирует от 1,17 % ±0,04 % до 1,41 % ±0,06 % и салидрозида - от 1,63 % ±0,05 % до 2,88 % ±0,12 % соответственно.Результаты статистической обработки свидетельствуют о том, что относительная ошибка среднего результата определения розавина и салидрозида с доверительной вероятностью 95 % не превышает ±5,0 %.
Teaching quality in neurosurgery: quantitating outcomes over time
Authors: Yong Raymund L. , Cheung William , Shrivastava Raj K. , Bederson Joshua B. 
Published: September 2021

OBJECTIVE
High-quality neurosurgery resident training is essential to developing competent neurosurgeons. Validated formative tools to assess faculty teaching performance exist, but are not used widely among Accreditation Council for Graduate Medical Education (ACGME) residency programs in the United States. Furthermore, their longer-term impact on teaching performance improvement and educational outcomes remains unclear. The goal of this study was to assess the impact of implementing an evaluation system to provide faculty with feedback on teaching performance in a neurosurgery residency training program over a 4-year period.

METHODS
The authors performed a prospective cohort study in which a modified version of the System for Evaluation of Teaching Qualities (SETQ) instrument was administered to neurosurgical trainees in their department regularly every 6 months. The authors analyzed subscale score dynamics to identify the strongest correlates of faculty teaching performance improvement. ACGME program survey results and trainee performance on written board examinations were compared for the 3 years before and after SETQ implementation.

RESULTS
The overall response rate among trainees was 91.8%, with 1044 surveys completed for 41 faculty. Performance scores improved progressively from cycle 1 to cycle 6. The strongest correlate of overall performance was providing positive feedback to trainees. Compared to the 3 years prior, the 3 years following SETQ implementation saw significant increases in written board examination and ACGME resident survey scores compared to the national mean.

CONCLUSIONS
Implementation of SETQ was associated with significant improvements in faculty teaching performance as judged by trainees over a 4-year period, and guided curricular changes in the authors’ training program that resulted in improved educational outcomes.
Stereotactic radiosurgery for secretory pituitary adenomas: systematic review and International Stereotactic Radiosurgery Society practice recommendations
Authors: Mathieu David , Kotecha Rupesh , Sahgal Arjun , De Salles Antonio , Fariselli Laura , Pollock Bruce E. , Levivier Marc , Ma Lijun , Paddick Ian , Regis Jean , Yomo Shoji , Suh John H. , Rubens Muni , Sheehan Jason P. 
Published: September 2021

OBJECTIVE
A systematic review was performed to provide objective evidence on the use of stereotactic radiosurgery (SRS) in the management of secretory pituitary adenomas and develop consensus recommendations.

METHODS
The authors performed a systematic review of the English-language literature up until June 2018 using the PRISMA guidelines. The PubMed (Medline), Embase, and Cochrane databases were searched. A total of 45 articles reporting single-institution outcomes of SRS for acromegaly, Cushing’s disease, and prolactinomas were selected and included in the analysis.

RESULTS
For acromegaly, random effects meta-analysis estimates for crude tumor control rate, crude endocrine remission rate, and any new hypopituitarism rates were 97.0% (95% CI 96.0%–98.0%), 44.0% (95% CI 35.0%–53.0%), and 17.0% (95% CI 13.0%–23.0%), respectively. For Cushing’s disease, random effects estimates for crude tumor control rate, crude endocrine remission rate, and any new hypopituitarism rate were 92.0% (95% CI 87.0%–95.0%), 48.0% (95% CI 35.0%–61.0%), and 21.0% (95% CI 13.0%–31.0%), respectively. For prolactinomas, random effects estimates for crude tumor control rate, crude endocrine remission rate, and any new hypopituitarism rate were 93.0% (95% CI 90.0%–95.0%), 28.0% (95% CI 19.0%–39.0%), and 12.0% (95% CI 6.0%–24.0%), respectively. Meta-regression analysis did not show a statistically significant association between mean margin dose with crude endocrine remission rate or mean margin dose with development of any new hypopituitarism rate for any of the secretory subtypes.

CONCLUSIONS
SRS offers effective tumor control of hormone-producing pituitary adenomas in the majority of patients but a lower rate of endocrine improvement or remission.
Depth of vertebral screw insertion using a cortical bone trajectory technique in lumbar spinal fusion: radiological significance of a long cortical bone trajectory
Authors: Matsukawa Keitaro , Yanai Yoshihide , Fujiyoshi Kanehiro , Kato Takashi , Yato Yoshiyuki 
Published: September 2021

OBJECTIVE
Contrary to original cortical bone trajectory (CBT), “long CBT” directed more anteriorly in the vertebral body has recently been recommended because of improved screw fixation and load sharing within the vertebra. However, to the authors’ knowledge there has been no report on the clinical significance of the screw length and screw insertion depth used with the long CBT technique. The aim of the present study was to investigate the influence of the screw insertion depth in the vertebra on lumbar spinal fusion using the CBT technique.

METHODS
A total of 101 consecutive patients with L4 degenerative spondylolisthesis who underwent single-level posterior lumbar interbody fusion at L4–5 using the CBT technique were included (mean follow-up 32.9 months). Screw loosening and bone fusion were radiologically assessed to clarify the factors contributing to these outcomes. Investigated factors were as follows: 1) age, 2) sex, 3) body mass index, 4) bone mineral density, 5) intervertebral mobility, 6) screw diameter, 7) screw length, 8) depth of the screw in the vertebral body (%depth), 9) facetectomy, 10) crosslink connector, and 11) cage material.

RESULTS
The incidence of screw loosening was 3.1% and bone fusion was achieved in 91.7% of patients. There was no significant factor affecting screw loosening. The %depth in the group with bone fusion [fusion (+)] was significantly higher than that in the group without bone fusion [fusion (−)] (50.3% ± 8.2% vs 37.0% ± 9.5%, respectively; p = 0.001), and multivariate logistic regression analysis revealed that %depth was a significant independent predictor of bone fusion. Receiver operating characteristic curve analysis identified %depth > 39.2% as a predictor of bone fusion (sensitivity 90.9%, specificity 75.0%).

CONCLUSIONS
This study is, to the authors’ knowledge, the first to investigate the significance of the screw insertion depth using the CBT technique. The cutoff value of the screw insertion depth in the vertebral body for achieving bone fusion was 39.2%.
External ventricular drainage for posthemorrhagic ventricular dilatation in preterm infants: insights on efficacy and failure
Authors: De Angelis Laura C. , Parodi Alessandro , Sebastiani Marianna , Consales Alessandro , Ravegnani Giuseppe M , Severino Mariasavina , Tortora Domenico , Rossi Andrea , Malova Mariya , Minghetti Diego , Cama Armando , Piatelli Gianluca , Ramenghi Luca A 
Published: September 2021

OBJECTIVE
The objective of this study was to describe the clinical and neuroradiological characteristics of a cohort of preterm infants who had undergone external ventricular drain insertion as a temporary measure to treat posthemorrhagic ventricular dilatation. In addition, the authors investigated the factors predicting permanent shunt dependency.

METHODS
The authors retrospectively reviewed the medical records of a cohort of preterm infants who had undergone external ventricular drain insertion at Gaslini Children’s Hospital (Genoa, Italy) between March 2012 and February 2018. They also analyzed clinical characteristics and magnetic resonance imaging data, including diffusion- and susceptibility-weighted imaging studies, which were obtained before both catheter insertion and removal.

RESULTS
Twenty-eight infants were included in the study. The mean gestational age was 28.2 ± 2.7 weeks, and the mean birth weight was 1209 ± 476 g. A permanent ventriculoperitoneal shunt was inserted in 15/28 (53.6%) infants because of the failure of external ventricular drainage as a temporary treatment option. Compared with the shunt-free group, the shunt-dependent group had a significantly lower gestational age (29.3 ± 2.3 vs 27.2 ± 2.7 weeks, p = 0.035) and tended toward a lower birth weight (p = 0.056). None of the clinical and neuroradiological characteristics significantly differed between the shunt-free and shunt-dependent groups at the time of catheter insertion. As expected, ventricular parameters as well as the intraventricular extension of intracerebral hemorrhage, as assessed using the intraventricular hemorrhage score, were reportedly higher in the shunt-dependent group than in the shunt-free group before catheter removal.

CONCLUSIONS
External ventricular drainage is a reliable first-line treatment for posthemorrhagic hydrocephalus. However, predicting its efficacy as a unique treatment remains challenging. A lower gestational age is associated with a higher risk of posthemorrhagic hydrocephalus progression, suggesting that the more undeveloped the mechanisms for the clearance of blood degradation products, the greater the risk of requiring permanent cerebrospinal fluid diversion, although sophisticated MRI investigations are currently unable to corroborate this hypothesis.
E Eksistensi Penganut Hindu Kaharingan Dalam Menjaga Kerukunan Umat Beragama di Kota Palangka Raya
Authors: Susi Susi 
Published: September 2021

Pembinaan kerukunan umat beragama adalah alat pemersatu bangsa dalam kondisi sosial kemasyarakatan yang majemuk dan pluralis. Garis besar penduduk Kota Palangka Raya terdiri dari beraneka ragam suku, agama, ras, antar golongan hidup berdampingan pada suatu wilayah dengan rukun dan ikut menjunjung toleransi antar sesama. Pentingnya menjaga kerukunan di tengah masyarakat yang majemuk maka setiap elemen masyarakat perlu berperan aktif mengelola dan mewujudkan kondisi kehidupan yang damai, harmonis, dan selaras.
Keberadaan penganut Hindu Kaharingan di Kota Palangka Raya salah satunya ikut ambil bagian menjaga kerukunan umat beragama di Kota Palangka Raya sebagai bentuk sikap responsif menghadapi persoalan kritis masyarakat yang majemuk. Konflik yang timbul akibat diferensiasi masyarakat tentu sewaktu-waktu bisa saja terjadi. Oleh karenanya pelaksanaan kerukunan hidup dengan mengamalkan trilogi kerukunan hidup umat beragama adalah strategi yang dilakukan demi mewujudkan rasa persatuan dan kesatuan masyarakat Kota Palangka Raya yang kian dinamis seiring perkembangan zaman.
Kesesuaian Fatwa DSN-MUI No 106 Dengan Praktik Wakaf Polis Di Lembaga Wakaf Al-Azhar Jakarta
Authors: Hendra  Kholid  , Maulida  Rahmawati  
Published: September 2021

Penelitian ini bertujuan untuk menganalisis mekanisme wakaf polis di Lembaga Wakaf Al-Azhar sehingga respon masyarakat begitu baik dan mengalami peningkatan jumlah peserta wakaf polis dengan pesat sehingga mencapai 200 polis. Dan bagaimana kesesuaian mekanisme tersebut dengan Fatwa Dewan Syariah Nasional No l06/DSN-MUI/IXl2016 Tentang Wakaf Manfaat Asuransi dan Manfaat Investasi pada Asuransi Jiwa Syariah (wakaf polis). Mekanisme pelaksanaan wakaf polis yang dilakukan oleh Lembaga Wakaf Al-Azhar memiliki ketentuan umum dan ketentuan khusus yaitu; Ketentuan umum yaitu wakif harus akil baligh, memiliki hak secara penuh atas harta yang akan diwakafkan, mengikuti ketentuan di perusahaan asuransi syariah, melakukan ikrar wakaf yang disaksikan oleh saksi-saksi, dan ikrar wakaf di legalisir notaris; Ketentuan khusus yaitu wakif diberi keleluasaan untuk memilih objek wakaf diantaranya untuk pembangunan masjid, pembangunan pesantren, wakaf produktif, lembaga-lembaga Islam, lembaga-lembaga social charity, badan usaha milik Wakaf Al-Azhar, atau objek wakaf bisa diberikan ke lembaga lain yang berbadan hukum. Hasil penelitian menunjukkan bahwa mekanisme pelaksanaan wakaf polis di Lembaga Wakaf Al-Azhar dianggap telah sesuai dengan fatwa DSN-MUI No.106/DSN-MUI/IX2016 tentang wakaf manfaat asuransi dan manfaat investasi pada asuransi jiwa syariah.
Mechano-Hypoxia Conditioning of Engineered Human Meniscus
Authors: Szojka Alexander R. A. , Li David Xinzheyang , Sopcak Malou E. J. , Ma Zhiyao , Kunze Melanie , Mulet-Sierra Aillette , Adeeb Samer M. , Westover Lindsey , Jomha Nadr M. , Adesida Adetola B. 
Published: September 2021

Meniscus fibrochondrocytes (MFCs) experience simultaneous hypoxia and mechanical loading in the knee joint. Experimental conditions based on these aspects of the native MFC environment may have promising applications in human meniscus tissue engineering. We hypothesized that in vitro “mechano-hypoxia conditioning” with mechanical loading such as dynamic compression (DC) and cyclic hydrostatic pressure (CHP) would enhance development of human meniscus fibrocartilage extracellular matrix in vitro. MFCs from inner human meniscus surgical discards were pre-cultured on porous type I collagen scaffolds with TGF-β3 supplementation to form baseline tissues with newly formed matrix that were used in a series of experiments. First, baseline tissues were treated with DC or CHP under hypoxia (HYP, 3% O2) for 5 days. DC was the more effective load regime in inducing gene expression changes, and combined HYP/DC enhanced gene expression of fibrocartilage precursors. The individual treatments of DC and HYP regulated thousands of genes, such as chondrogenic markers SOX5/6, in an overwhelmingly additive rather than synergistic manner. Similar baseline tissues were then treated with a short course of DC (5 vs 60 min, 10–20% vs 30–40% strain) with different pre-culture duration (3 vs 6 weeks). The longer course of loading (60 min) had diminishing returns in regulating mechano-sensitive and inflammatory genes such as c-FOS and PTGS2, suggesting that as few as 5 min of DC was adequate. There was a dose-effect in gene regulation by higher DC strains, whereas outcomes were inconsistent for different MFC donors in pre-culture durations. A final set of baseline tissues was then cultured for 3 weeks with mechano-hypoxia conditioning to assess mechanical and protein-level outcomes. There were 1.8–5.1-fold gains in the dynamic modulus relative to baseline in HYP/DC, but matrix outcomes were equal or inferior to static controls. Long-term mechano-hypoxia conditioning was effective in suppressing hypertrophic markers (e.g., COL10A1 10-fold suppression vs static/normoxia). Taken together, these results indicate that appropriately applied mechano-hypoxia conditioning can support meniscus fibrocartilage development in vitro and may be useful as a strategy for developing non-hypertrophic articular cartilage using mesenchymal stem cells.
A Novel CpG Methylation Risk Indicator for Predicting Prognosis in Bladder Cancer
Authors: Guo Yufeng , Yin Jianjian , Dai Yuanheng , Guan Yudong , Chen Pinjin , Chen Yongqiang , Huang Chenzheng , Lu Yong-Jie , Zhang Lirong , Song Dongkui 
Published: September 2021

PurposeBladder cancer (BLCA) is one of the most common cancers worldwide. In a large proportion of BLCA patients, disease recurs and/or progress after resection, which remains a major clinical issue in BLCA management. Therefore, it is vital to identify prognostic biomarkers for treatment stratification. We investigated the efficiency of CpG methylation for the potential to be a prognostic biomarker for patients with BLCA.Patients and MethodsOverall, 357 BLCA patients from The Cancer Genome Atlas (TCGA) were randomly separated into the training and internal validation cohorts. Least absolute shrinkage and selector operation (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) were used to select candidate CpGs and build the methylation risk score model, which was validated for its prognostic value in the validation cohort by Kaplan–Meier analysis. Hazard curves were generated to reveal the risk nodes throughout the follow-up. Gene Set Enrichment Analysis (GSEA) was used to reveal the potential biological pathways associated with the methylation model. Quantitative real-time polymerase chain reaction (PCR) and western blotting were performed to verify the expression level of the methylated genes.ResultsAfter incorporating the CpGs obtained by the two algorithms, CpG methylation of eight genes corresponding to TNFAIP8L3, KRTDAP, APC, ZC3H3, COL9A2, SLCO4A1, POU3F3, and ADARB2 were prominent candidate predictors in establishing a methylation risk score for BLCA (MRSB), which was used to divide the patients into high- and low-risk progression groups (p &lt; 0.001). The effectiveness of the MRSB was validated in the internal cohort (p &lt; 0.001). In the MRSB high-risk group, the hazard curve exhibited an initial wide, high peak within 10 months after treatment, whereas some gentle peaks around 2 years were noted. Furthermore, a nomogram comprising MRSB, age, sex, and tumor clinical stage was developed to predict the individual progression risk, and it performed well. Survival analysis implicated the effectiveness of MRSB, which remains significant in all the subgroup analysis based on the clinical features. A functional analysis of MRSB and the corresponding genes revealed potential pathways affecting tumor progression. Validation of quantitative real-time PCR and western blotting revealed that TNFAIP8L3 was upregulated in the BLCA tissues.ConclusionWe developed the MRSB, an eight-gene-based methylation signature, which has great potential to be used to predict the post-surgery progression risk of BLCA.