bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patiromer for the management of hyperkalaemia in patients receiving renin–angiotensin–aldosterone system inhibitors for heart failure: design and rationale of the DIAMOND trial
Authors: Butler Javed , Anker Stefan D. , Siddiqi Tariq Jamal , Coats Andrew J.S. , Dorigotti Fabio , Filippatos Gerasimos , Friede Tim , Göhring Udo‐Michael , Kosiborod Mikhail N. , Lund Lars H. , Metra Marco , Moreno Quinn Carol , Piña Ileana L. , Pinto Fausto J. , Rossignol Patrick , Szecsödy Peter , Van Der Meer Peter , Weir Matthew , Pitt Bertram 
Published: November 2021

AimsIn patients with current or a history of hyperkalaemia, treatment with renin–angiotensin–aldosterone system inhibitors (RAASi) is often compromised. Patiromer, a novel potassium (K+) binder, may improve serum K+ levels and adherence to RAASi.MethodsThe DIAMOND trial will enroll ∼820 patients with heart failure with reduced ejection fraction (HFrEF; ejection fraction ≤40%). Patients meeting the screening criteria will enter a single‐blinded run‐in phase where they will be started or continued on a mineralocorticoid receptor antagonist (MRA) titrated to 50 mg/day and other RAASi therapy to ≥50% target dose, and patiromer. Patiromer will be titrated up to a maximum three packs/day (8.4 g/pack) to achieve optimal doses of RAASi without hyperkalaemia. The run‐in phase will last up to 12 weeks, following which patients will undergo double‐blind randomization in a 1:1 ratio to receive either continued patiromer or placebo (patiromer withdrawal). The primary endpoint is the mean difference in serum K+ from randomization between patiromer and placebo arms. Secondary endpoints will include hyperkalaemia events with K+ value >5.5 mEq/L, durable enablement of MRA at target dose, investigator‐reported adverse events of hyperkalaemia, hyperkalaemia‐related clinical endpoints and an overall RAASi use score (using a 0–8‐point scale) comprising all‐cause death, occurrence of cardiovascular hospitalization or usage of comprehensive heart failure medication.ConclusionThe DIAMOND trial is designed to determine if patiromer can favourably impact K+ control in patients with HFrEF with hyperkalaemia or a history of hyperkalaemia leading to RAASi therapy compromise, and in turn improve RAASi use.
Human Papilloma Virus‐11 DNA Detection by Graphene‐PAMAM Modified Impedimetric CRISPR‐dCas9 Biosensor
Authors: Mumcu Mehmet Utku , Ertuğrul Uygun Hilmiye Deniz , Uygun Zihni Onur 
Published: November 2021

AbstractHuman Papilloma Virus‐11 (HPV‐11) is leads to condylomata acuminata (CA), which has commonly known as genital wards that global widespread incidence of 160 to 289 cases per year. In the first‐time literature, we detect HPV‐11 DNA by using dCas9 modified graphene oxide‐PAMAM modified electrodes, impedimetrically. Chronoimpedimetric detection was facilitated the biosensor response time optimization of HPV‐11 DNA in 5 minutes. The biosensor has ability to analyze HPV‐11 DNA between 50 pM and 1000 pM with good linearity, sensitivity and selectivity. Moreover, we tested our biosensor in real samples matrix by considering recovery of the samples.
3D printable solid and quasi‐solid electrolytes for advanced batteries
Authors: Ben‐Barak Ido , Ragones Heftsi , Golodnitsky Diana 
Published: November 2021

AbstractCompared with traditional lithium‐ion systems, solid‐state batteries could achieve significantly higher energy density and improved safety. The design and method of synthesis of solid electrolytes are known to affect the electrochemical performance and mechanical integrity of a battery upon charge/discharge. 3D printing, while being the most advanced method for the fabrication of solid electrolytes, remains a bottleneck in the all‐printed batteries and, hitherto, has not been systematically investigated. In this mini‐review, an attempt has been made to address the issue of 3D printing of ceramic and polymer electrolytes by utilizing different approaches, in order to compare the conductivity of printed electrolytes and the electrolytes prepared by standard methods, and to propose investigation and development directions in this rapidly growing field.
Theoretical and experimental determination of proppant‐crushing ratio and fracture conductivity with different particle sizes
Authors: Guo Zixi , Zhao Jinzhou , Li Yongming , Zhao Yunxiang , Hu Haoran 
Published: November 2021

AbstractCrushing ratio and fracture conductivity are two key indicators for proppant evaluation. The most common way to evaluate these two indicators is physical testing, but physical testing is costly and time‐consuming, and the results are unstable. Therefore, a method for calculating proppant‐crushing ratio and fracture conductivity is proposed to replace repetitive physical experiments. However, in past attempts, only mathematical models using the same particle size have been established, while the particle‐size distribution in actual proppant arrangement is within a certain numerical range. Therefore, in order to establish a mathematical model more consistent with the actual situation of proppant arrangement, firstly, the Monte Carlo method was used to simulate proppant particles arranged with different particle sizes, and then a mathematical model was established describing the force of proppant particles. Secondly, according to the sparse, ill‐conditioned, and asymmetric characteristics of the coefficient matrix, an improved singular value decomposition method is proposed to improve the accuracy and efficiency of calculation. Finally, the crushing ratio and fracture conductivity of proppant were calculated through the new model in this paper. It was found that the results calculated by the new model in this paper are closer to actual test results.
Combined foliar application of zinc sulphate and selenite affects the magnitude of selenium biofortification in wheat (Triticum aestivum L.)
Authors: Ning Peng , Fei Peiwen , Wu Tianqi , Li Yafei , Qu Chunyan , Li Yunuo , Shi Jianglan , Tian Xiaohong 
Published: November 2021

AbstractCombined foliar application of zinc sulphate (ZnSO4) and selenium (Se) has been practiced in wheat biofortification. However, it remains elusive that whether the combined application affects Zn and Se distribution to grain, the efficacy of biofortification and bioavailability in wheat, due to the accompanying sulphate sources. Selenite and ZnSO4 were applied either alone or simultaneously to foliage of wheat in field, and their impacts on Zn and Se partitioning in plants, enrichment and bioavailability in whole grain, bran and flour, as well as amino acid profile in flour, were closely investigated. Grain yield was not influenced by any of the foliar Zn and Se applications. Grain Zn and Se concentrations reached 58.3–77.9 and 0.30–0.74 mg kg−1 in Zn‐ and Se‐sprayed plants, respectively, and the estimated daily‐absorbed Zn by a reference adult from grain and flour were enhanced by 1.2‐ to 2.4‐fold than the control, as well as 16.8‐fold increase on average for daily Se intake. Combined Zn and Se application led to a 32%–37% reduction in Se concentrations and daily Se intake of whole grain and flour in one of the two seasons when compared with the foliar Se spray alone, which was partly associated with the reduced Se distribution to grains. Alternatively, similar responsive patterns of methionine and cysteine with grain and flour Se concentrations further suggested that zinc sulphate and selenium interactions in Se accumulation act through the metabolism of sulphur‐containing amino acids in wheat plants. Further, the substantial Zn enrichment in flour paralleled to the increase of amino acid profiles such as aspartate, glutamate, glycine and lysine, but not to the total amino acid content. Overall, wheat was successfully biofortified with Zn and Se through combined foliar applications, although an antagonistic impact of ZnSO4 spray on the magnitude of Se biofortification occurred in some cases.
Soil chemical changes in ancient irrigated fields of Udhruḥ, southern Jordan
Authors: Velasco‐Sánchez Ángel , Driessen Mark J. , Abudanah Fawzi , Nobels Peter R. , Comans Rob N. J. , Hoosbeek Marcel R. 
Published: November 2021

AbstractSince ancient times, irrigation has been fundamental for achieving large agricultural yields, especially in the more arid areas of the world. An example of this practice is represented by the vast water infrastructures found near Udhruḥ (southern Jordan). These engineering works were constructed, maintained and restored from the Nabataean to early Islamic periods (first century BCE to eighth century CE). It still remains unknown why the ancient agricultural landscape of the region shifted towards an unproductive desert. In this study, we analysed the soil chemical and physical properties of an ancient irrigated field to assess whether ancient agricultural practices have altered soil properties that are still noticeable today, and might have contributed to the abandonment of the area. Soil samples were taken randomly from within an ancient qanat‐irrigated agricultural field and from adjacent surfaces believed never to have been irrigated. Our results indicate that the effects of irrigation are still detectable today; electrical conductivity and total Na, B, Li and Sr in the soil of the ancient fields were significantly lower than those in the undisturbed control soils, which suggests leaching of soluble elements due to irrigation. Our results provide evidence of the mastery of ancient civilizations in their agricultural practices. Engineers and farmers apparently managed to conduct irrigation in the area of Udhruḥ for long periods of time without causing soil degradation.
Estimating variations in the use of antibiotics in primary care: Insights from the Tuscany region, Italy
Authors: Willmington Claire , Vainieri Milena , Seghieri Chiara 
Published: November 2021

AbstractBackgroundPractice variation is a well‐known phenomenon that affects all aspects of healthcare delivery and leads to suboptimal health outcomes as well as poor resource allocation. Given the global rise of antimicrobial resistance, practice variation is of particular concern when it comes to the prescription of antibiotics. A growing number of healthcare systems are tackling this issue at all levels of healthcare governance.Aims and objectivesThis study sought to estimate the variation in antibiotic use across different levels of Tuscany's primary care, and assess the extent to which the organization of primary care delivery is responsible for this variation.MethodsWe analysed the performance and variation for seven indicators related to the use of antibiotics at three levels of healthcare governance: (i) the clinician level (2619 general practitioners [GPs]); (ii) the peer‐group level (all 116 GP group practices) and (iii) the institutional level (all 26 health districts). For the statistical analysis, we built three‐level mixed effects models that were fitted with 2619 GPs, 116 GP group practices and 26 health districts.ResultsThe multi‐level models suggested that the grand majority of the variation in antibiotic use was located at the GP level (75% to 97%). However, the percentage of variation associated with GP group practices and health districts ranged from 3% to 25%, depending on the type of indicator analysed.ConclusionWhile the variation was found to be in large part due to differences between GPs themselves, the influence exerted by peer groups and institutional mechanisms does have a significant impact as well. Further research needs to be conducted regarding the institutional and contextual factors that prompt GPs to harmonize their prescribing behaviour in line with best practices and lead to not only improved patient outcomes but also large cost‐savings.
The relationship between emergent drawing, emergent writing, and visual‐motor integration in preschool children
Authors: Pinto Giuliana , Incognito Oriana 
Published: November 2021

AbstractDrawing and writing are two major representational systems with many common aspects. Each also has its own system of rules, characterized by different degrees of visual realism and conventionality. The relationship between them at their emergence and the contribution of perceptual and motor skills to their development have been under‐investigated, leading to discordant study results. This study investigated the emergence of the ability to draw and write and the association between these two processes in 3‐ to 5‐year‐old preschoolers, controlling for the role played by visual‐motor integration ability. A total of 115 preschoolers were tested for drawing and writing tasks and visual‐motor integration. Variance analysis, correlation analysis, and covariance analysis were performed. The results illustrated a stable association between drawing and writing in the age range considered, which can be traced to their common representational core. Moreover, the weight of visual‐motor coordination is differentiated for the two notational systems.
The development of “automated visual evaluation” for cervical cancer screening: The promise and challenges in adapting deep‐learning for clinical testing
Authors: Desai Kanan T. , Befano Brian , Xue Zhiyun , Kelly Helen , Campos Nicole G. , Egemen Didem , Gage Julia C. , Rodriguez Ana‐Cecilia , Sahasrabuddhe Vikrant , Levitz David , Pearlman Paul , Jeronimo Jose , Antani Sameer , Schiffman Mark , de Sanjosé Silvia 
Published: November 2021

AbstractThere is limited access to effective cervical cancer screening programs in many resource‐limited settings, resulting in continued high cervical cancer burden. Human papillomavirus (HPV) testing is increasingly recognized to be the preferable primary screening approach if affordable due to superior long‐term reassurance when negative and adaptability to self‐sampling. Visual inspection with acetic acid (VIA) is an inexpensive but subjective and inaccurate method widely used in resource‐limited settings, either for primary screening or for triage of HPV‐positive individuals. A deep learning (DL)‐based automated visual evaluation (AVE) of cervical images has been developed to help improve the accuracy and reproducibility of VIA as assistive technology. However, like any new clinical technology, rigorous evaluation and proof of clinical effectiveness are required before AVE is implemented widely. In the current article, we outline essential clinical and technical considerations involved in building a validated DL‐based AVE tool for broad use as a clinical test.
Primary renal leiomyosarcoma with a tumor thrombus in the inferior vena cava
Authors: Konno Mikio , Osawa Takahiro , Hotta Kiyohiko , Shimizu Ai , Abe Takashige , Matsumoto Ryuji , Kikuchi Hiroshi , Shinohara Nobuo 
Published: November 2021

IntroductionWe report a rare case of primary renal leiomyosarcoma with a tumor thrombus in the inferior vena cava.Case presentationA 54‐year‐old woman presented with right flank pain and abdominal distension. Physical examination findings were unremarkable. Abdominal computed tomography revealed a heterogeneously enhancing right solid renal mass with a thrombus in the renal vein extending into the inferior vena cava. Magnetic resonance imaging demonstrated a renal tumor with a thrombus about 4 cm below the hepatic vein. Chest computed tomography and bone scintigraphy were negative. The patient underwent right radical nephrectomy and vena cava thrombectomy. Histophathologic evaluation of the resected tumor confirmed the diagnosis of leiomyosarcoma. She underwent no adjuvant therapy. Seven months after surgery, the patient died following a 2‐month history of multiple pulmonary and hepatic metastases.ConclusionThis report highlights the importance of considering the possibility of renal leiomyosarcoma invasion to the inferior vena cava, similar to renal cell carcinoma.
Testicular metastasis from urothelial carcinoma of the bladder
Authors: Fukagawa Eri , Endo Fumiyasu , Kyono Yoko , Hashimoto Jun , Hattori Kazunori 
Published: November 2021

IntroductionReports of urothelial carcinoma with testicular metastasis are limited and the etiology and prognosis remain unclear. We report a rare case of testicular metastasis derived from bladder urothelial carcinoma.Case presentationA 68‐year‐old man presented with gross hematuria and urinary frequency. Cystoscopy demonstrated an 8‐cm‐sized tumor in the bladder; transurethral resection and magnetic resonance imaging confirmed invasive urothelial carcinoma. Cystoprostatourethrectomy was performed, and the pathological diagnosis was high‐grade muscle‐invasive urothelial carcinoma. Three years later, the patient noticed a left scrotal mass. Left high orchiectomy was performed, and histopathologic examination of the surgical specimen revealed urothelial carcinoma, confirming testicular metastasis derived from bladder cancer. The patient received chemotherapy with gemcitabine and cisplatin and has survived for 7 years since the initial diagnosis without progression.ConclusionAlthough rare, secondary lesions should be considered for the differential diagnosis of testicular tumors in patients with a history of urothelial carcinoma.
Clinical pharmacy initiative to increase naloxone prescribing in patients with opioid use disorder
Authors: Smith Rachel , Tran Sylvia , Stevens Shelley , Powers Jennifer , Gunn Maria , Nguyen Tuong‐My , Bovio Franck Jessica 
Published: November 2021

AbstractIntroductionThe national opioid epidemic has garnered the attention of various health agencies. A leading strategy in mitigating risk from the opioid public health crisis, including opioid use disorder (OUD), is via increased promotion and access to the lifesaving opioid antagonist, naloxone. Pharmacists have been recognized as integral in addressing this emergency; however, literature evaluating outcomes from multifaceted clinical pharmacy specialist (CPS) interventions and involvement is lacking. The purpose of this quality improvement initiative was to evaluate the impact of a CPS initiative to increase naloxone prescribing proportions (number of patients with OUD with an active prescription for naloxone within the past year divided by the number of patients with OUD), patient access to care, and clinical interventions.MethodsPain management CPSs, mental health CPSs, and clinical pharmacy leadership within a Veterans Health System spearheaded a variety of interventions to increase naloxone prescribing in patients with OUD including focused education with prescribers, naloxone informational letters, review of population management tools identifying patients with OUD indicated to receive naloxone, CPS naloxone prescribing, and automated naloxone drug orders integrated into electronic health record progress note templates. The preintervention and postintervention evaluation periods were three‐month time frames. Naloxone prescribing proportions were compared before and after implementation of these interventions. Additional outcomes evaluated were number of encounters, number of patients seen/reviewed, and number of clinical interventions completed by the CPSs.ResultsThere was a significant increase observed in naloxone prescribing proportions from 34.1% to 57.5% postintervention (P < .01). The total number of encounters, patients, and clinical interventions had an absolute increase of 58.0%, 88.4%, and 49.9%, respectively, postintervention.ConclusionThe observed improvement in naloxone prescribing proportions suggests the value of CPS involvement in initiatives for increasing naloxone prescribing to optimize patient safety and justify clinical pharmacy services.
The context of disclosing suicidality: An exploration with attempt survivors
Authors: Sheehan Lindsay , Oexle Nathalie , Armas Silvia A. , Wan Hoi Ting , Bushman Michael , Glover LaToya , Lewy Stanley , Laique Aamir 
Published: November 2021

AbstractSuicide attempt survivors selectively disclose suicidal ideation and suicide attempts. However, little is known about how suicide attempt survivors make these disclosure decisions. To address the dearth of research on the context of suicide disclosure, a community‐based participatory research team analyzed qualitative data from suicide attempt survivors (n = 40) to examine when, how, and to whom they disclose suicidality. We describe findings on three main themes: (1) who to tell, (2) when to tell, and (3) how to tell. Within subthemes, we provide examples of diverse disclosure‐related strategies, including gradual disclosure, adapting disclosure to the audience, and determining the emotional readiness of both discloser and confidant. Counselors can use the study results to aid suicide attempt survivors in making disclosure decisions and crafting disclosure messages that maximize benefits for suicide attempt survivors and those to whom they disclose.
Microarray analysis of circRNAs sequencing profile in exosomes derived from bone marrow mesenchymal stem cells in postmenopausal osteoporosis patients
Authors: Fu Miao , Fang Liping , Xiang Xi , Fan Xijing , Wu Junqi , Wang Jinhua 
Published: November 2021

AbstractIntroductionBone marrow‐derived mesenchymal stem cells (BMSCs)‐derived exosomes are involved in the modulation of tissue repair and regeneration. CircRNAs play important roles in BMSCs exosomes. The current study sought to explore the role of circRNAs in exosomes derived from BMSCs of postmenopausal osteoporosis (PMOP) patients and the underlying mechanisms.MethodsRNA was extracted from BMSCs exosomes of PMOP and a control group. RNA microarray and bioinformatics analyses were used to explore the expression profile and functions circRNAs. Differentially expressed circRNAs from 20 PMOP and 20 controls were analyzed using RT‐qPCR.ResultsA total of 237 upregulated and 279 downregulated circRNAs were identified in the current study. The top‐10 most upregulated circRNAs in the PMOP group were hsa_circ_0069691, hsa_circ_0005678, hsa_circ_0006464, hsa_circ_0015813, hsa_circ_0000511, hsa_circ_0076527, hsa_circ_0009127, hsa_circ_0047285, hsa_circ_0027741, and hsa_circ_0090949. The top‐10 most downregulated circRNAs were hsa_circ_0048669, hsa_circ_0090247, hsa_circ_0070899, hsa_circ_0087557, hsa_circ_0045963, hsa_circ_0090180, hsa_circ_0058392, hsa_circ_0040751, hsa_circ_0067910, and hsa_circ_0049484. RT‐PCR verified dysregulation of 5 circRNAs including hsa_circ_0009127, hsa_circ_0090759, hsa_circ_0058392, hsa_circ_0090247, and hsa_circ_0049484. Moreover, a circRNA‐microRNA‐mRNA interaction network was developed based on differentially expressed circRNAs. Functional analysis showed that pathways involved in the regulation of autophagy, PI3K‐Akt signaling, FoxO signaling, and MAPK signaling were associated with the differentially expressed circRNAs in PMOP patients.ConclusionThe findings of this study show dysregulated circRNAs in BMSCs exosomes of PMOP patients, which may affect the progression of PMOP. These circRNAs can be used as predictive biomarkers and as therapeutic targets for the treatment of PMOP.