bluuebunny/crossref_metadata_2025_split huggingface dataset:
The environmental geochemical baseline, background and sources of metal and metalloids present in urban, peri-urban and rural soils in the O´Higgins region, Chile
Authors: Valdés Durán Ana , Aliaga Guillermo , Deckart Katja , Karas Cyrus , Cáceres Dante , Nario Adriana 
Published: October 2021

AbstractThe importance of environmental geochemistry baseline in soils of O´Higgins Region, Chile, since it hosts in its eastern area one of the major Cu-Mo producing mines in the country, is to establish and explain relationships between the chemical compositions of the Earth’s surface and potential contaminants sources such as mining industry, agriculture and urban activity. A total of 109 samples of urban, peri-urban and rural soils were analyzed with X-ray fluorescence to determine most of the elemental concentrations analyzed. The C and S analyses were performed with the high-temperature combustion method, and a MERCUR mercury analyzer was used for Hg. The study shows that the distribution patterns for most major elements and some trace elements are controlled by the lithologic substrate. This study identified areas with metals and metalloids in high concentrations, which are a risk to the environment and health according to established international regulations. Some of these components correspond to Cu (2500 ppm), Mo (26,5 ppm), As (134,6 ppm), Cr (206.6 ppm), Hg (0.2 ppm), Ni (26.4 ppm), Pb (61.7 ppm), V (227,2 ppm) and Zn (180.3 ppm). Through an elementary association analysis, most of these elements resulted from extractive activities of Cu, metal alloys and oil combustion. It was also possible to trace the use of fertilizers and pesticides in agricultural soils, as well as the combustion of oil related to vehicles in the study area. This information is relevant to implement environmental management strategies to control possible exposure to toxic compounds to human health.
Cultural Differences in the Association of Harsh Parenting with Internalizing and Externalizing Symptoms: A Meta-Analysis
Authors: Pinquart Martin 
Published: October 2021

AbstractThe goal of the present meta-analysis was to compare associations of harsh parenting with internalizing and externalizing symptoms across regions of the globe and ethnic groups, and to search for moderator effects of indicators of cultural normativeness of harsh parenting. The systematic search in electronic databases and cross-referencing identified 971 studies. Random-effects meta-analyses were computed on bivariate and cross-lagged associations. Harsh parenting was associated with more internalizing and externalizing symptoms in all assessed regions of the globe and in all compared ethnic groups within western countries. Cross-lagged statistical effects of harsh parenting on change in child symptoms were found in North America, Western Europe, Latin America, East Asia, South-East Asia, and North Africa/the Arabian Peninsula, while there were no data from Eastern Europe. In line with the cultural normativeness hypothesis, a few moderating effects of the legal ban of physical punishment of children, acceptance and prevalence of physical punishment, and individualism-collectivism were identified. Externalizing symptoms predicted a stronger increase in harsh parenting if physical punishment was more accepted in the individual country. However, national levels of acceptance of physical punishment did not affect associations of harsh parenting with change in child outcomes. Although most associations of harsh parenting with child symptoms were statistically small (bivariate associations) or very small (cross-lagged associations), it is concluded that parents across the globe should be recommended to avoid harsh parenting. More longitudinal studies are needed for analyzing regional differences in parent and child effects.
On the global Hadamard parametrix in QFT and the signed squared geodesic distance defined in domains larger than convex normal neighbourhoods
Authors: Moretti Valter 
Published: October 2021

AbstractWe consider the global Hadamard condition and the notion of Hadamard parametrix whose use is pervasive in algebraic QFT in curved spacetime (see references in the main text). We point out the existence of a technical problem in the literature concerning well-definedness of the global Hadamard parametrix in normal neighbourhoods of Cauchy surfaces. We discuss in particular the definition of the (signed) geodesic distance $$\sigma $$
σ
and related structures in an open neighbourhood of the diagonal of $$M\times M$$

M
×
M

larger than $$U\times U$$

U
×
U

, for a normal convex neighbourhood U, where (M, g) is a Riemannian or Lorentzian (smooth Hausdorff paracompact) manifold. We eventually propose a quite natural solution which slightly changes the original definition by Kay and Wald and relies upon some non-trivial consequences of the paracompactness property. The proposed re-formulation is in agreement with Radzikowski’s microlocal version of the Hadamard condition.
Modelling trend life cycles in scientific research using the Logistic and Gompertz equations
Authors: Tattershall E. , Nenadic G. , Stevens R. D. 
Published: October 2021

AbstractScientific topics vary in popularity over time. In this paper, we model the life cycles of 200 trending topics by fitting the Logistic and Gompertz models to their frequency over time in published abstracts. Unlike other work, the topics we use are algorithmically extracted from large datasets of abstracts covering computer science, particle physics, cancer research, and mental health. We find that the Gompertz model produces lower median error, leading us to conclude that it is the more appropriate model. Since the Gompertz model is asymmetric, with a steep rise followed a long tail, this implies that scientific topics follow a similar trajectory. We also explore the case of double-peaking curves and find that in some cases, topics will peak multiple times as interest resurges. Finally, when looking at the different scientific disciplines, we find that the lifespan of topics is longer in some disciplines (e.g. cancer research and mental health) than it is others, which may indicate differences in research process and culture between these disciplines.
A modular environmental and economic assessment applied to the production of Hermetia illucens larvae as a protein source for food and feed
Authors: Spykman Raphaela , Hossaini Sayed Mahdi , Peguero Daniela A. , Green Ashley , Heinz Volker , Smetana Sergiy 
Published: October 2021

Abstract
Purpose
The inclusion of insect protein into the food system has been proposed as a promising solution to ensure future food security and mitigate negative environmental impacts related to food production. However, the market volume for edible insects in Europe is still small; consequently, producers need a decision-support system to ensure the sustainable upscaling of the sector. The study analyzed environmental and economic impacts of insect production to identify the most eco-efficient production scenarios.

Methods
A novel modular eco-efficiency assessment approach was developed to analyze the production of dried Hermetia illucens larvae. An exemplary, industrial-scale insect production system was disaggregated into a total of 29 module variants that can be combined into 4608 distinct production scenarios, which are characterized by different feeds, energy efficiencies, and processing technologies. Environmental life cycle and cost assessments were carried out for each module variant, and eco-efficiency assessment was used to jointly assess these two sustainability dimensions. Additionally, the influence of the insect feed on the production system performance and impact was investigated by employing feed-specific scaling factors. These were used to aggregate module results into production scenario results.

Results and discussion
The most eco-efficient production scenarios include energy-efficient rearing facilities that rely on blanching and microwave drying for processing. The insect feed is the largest contributor to the environmental impacts and costs, but from an eco-efficiency standpoint, the choice of feed might not be crucial. Waste-type feeds (e.g., manure, fruit, and vegetable waste) have low environmental impacts and costs, but the production scenarios based on these feeds are less efficient. The low impacts of the feed are offset by higher impacts during the rearing and processing stages. Conversely, scenarios based on higher quality feeds (e.g., by-products like wheat middlings or distiller’s grains) require less resources, but the initial feed impacts and costs are higher. Moreover, of the feed types studied, only highly processed ones, such as compound chicken feed, should be avoided for insect rearing.

Conclusions
The developed modular assessment approach is efficient in assessing multiple potential insect production scenarios. It can be adapted to incorporate additional variations of the production system via additional modules. Limitations include the potential for redundant module combinations and the up-front time investment needed. Finally, the results are sensitive to methodological choices: thus, these should be carefully considered and communicated during the design of the modular assessment system.
Transition to telehealth
Authors: Cheng Chelsea , Humphreys Hilary , Kane Bridget 
Published: October 2021

AbstractIn recent years, telemedicine has been increasingly incorporated into medical practice, a process which has now been accelerated by the COVID-19 pandemic. As telemedicine continues to progress, it is necessary for medical institutions to incorporate telemedicine into their curricula, and to provide students with the necessary skills and experience to effectively carry out telemedicine consultations. The purposes of this study are to review the involvement of medical students with telemedicine and to determine both the benefits and the challenges experienced. A literature review on the MEDLINE; CINAHL Plus; APA PsychInfo; Library, Information Science and Technology Abstracts; and Health Business Elite databases was performed on September 7, 2020, yielding 561 results. 33 manuscripts were analysed, with the main benefits and challenges experienced by medical students summarized. In addition to increasing their understanding of the importance of telemedicine and the acquisition of telemedicine-specific skills, students may use telemedicine to act as a valuable workforce during the COVID-19 pandemic. Challenges that students face, such as discomfort with carrying out telemedicine consults and building rapport with patients, may be addressed through the incorporation of telemedicine teaching into the medical curricula through experiential learning. However, other more systemic challenges, such as technical difficulties and cost, need to be examined for the full benefits of telemedicine to be realized. Telemedicine is here to stay and has proven its worth during the COVID-19 pandemic, with medical students embracing its potential in assisting in medical clinics, simulation of clinical placements, and online classrooms.
Premenstrual Exacerbations of Mood Disorders: Findings and Knowledge Gaps
Authors: Kuehner Christine , Nayman Sibel 
Published: October 2021

Abstract
Purpose of Review
In contrast to premenstrual dysphoric disorder (PMDD), premenstrual exacerbations (PMEs) of ongoing mood disorders are understudied. The aim of this review is to describe diagnostic issues, epidemiology, underlying mechanisms, and treatment for PME in unipolar depression and bipolar disorder, and to discuss clinical and research implications.

Recent Findings
Community-based and clinical studies estimate that in women with mood disorders around 60% report PME, while some women with bipolar disorder also show symptom exacerbations around ovulation. In general, PME predicts a more severe illness course and an increased burden. While heightened sensitivity to fluctuations of sex hormone levels across the menstrual cycle appears to contribute to PME and PMDD, the overlap of their underlying biological mechanisms remains unclear. Beneficial treatments for PMDD show less or no efficacy in PME. Pharmacological treatments for PME in mood disorders predominantly seem to profit from adjustable augmentation of treatment dosages during the luteal phase for the underlying disorder. However, the evidence is sparse and mainly based on earlier small studies and case reports.

Summary
Previous research is mainly limited by the lack of a clear differentiation between PME and PMDD comorbidity with mood disorders. More systematic research with uniformly defined and prospectively assessed subgroups of PME in larger epidemiological and clinical samples is needed to receive reliable prevalence estimates and information on the clinical impact of PME of mood disorders, and to uncover underlying mechanisms. In addition, larger randomized controlled trials are warranted to identify efficacious pharmacological and psychotherapeutic treatments for affected women.
The Ascent of Artificial Intelligence in Endourology: a Systematic Review Over the Last 2 Decades
Authors: Hameed B. M. Zeeshan , Shah Milap , Naik Nithesh , Rai Bhavan Prasad , Karimi Hadis , Rice Patrick , Kronenberg Peter , Somani Bhaskar 
Published: October 2021

Abstract
Purpose of Review
To highlight and review the application of artificial intelligence (AI) in kidney stone disease (KSD) for diagnostics, predicting procedural outcomes, stone passage, and recurrence rates. The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist.

Recent Findings
This review discusses the newer advancements in AI-driven management strategies, which holds great promise to provide an essential step for personalized patient care and improved decision making. AI has been used in all areas of KSD including diagnosis, for predicting treatment suitability and success, basic science, quality of life (QOL), and recurrence of stone disease. However, it is still a research-based tool and is not used universally in clinical practice. This could be due to a lack of data infrastructure needed to train the algorithms, wider applicability in all groups of patients, complexity of its use and cost involved with it.

Summary
The constantly evolving literature and future research should focus more on QOL and the cost of KSD treatment and develop evidence-based AI algorithms that can be used universally, to guide urologists in the management of stone disease.
A Recyclable Dipping Strategy to Stabilize Herring (Clupea harengus) Co-products During Ice Storage
Authors: Wu Haizhou , Forghani Bita , Sajib Mursalin , Undeland Ingrid 
Published: October 2021

AbstractApplying value-adding techniques to fish filleting co-products is rendered difficult due to their high susceptibility to lipid oxidation, microbial spoilage, and amine formation. In this study, a recyclable dipping strategy was developed and investigated for its ability to stabilize herring (Clupea harengus) co-products (head, backbone, caudal fin, intestines, belly flap, skin, and in some cases roe) against oxidation and microbial spoilage. From initial screening of seven antioxidative components/formulas in minced herring co-products during ice storage, an oil-soluble rosemary extract (RE-B) and isoascorbic acid (IAA) were identified as most promising candidates. These compounds were then formulated to a recyclable solution to be used for dipping of the herring co-products. The commercial Duralox MANC antioxidant mixture was used as a positive control. Dipping in 0.2% RE-B solution ± 0.5% IAA or in 2% Duralox MANC solutions remarkably increased the oxidation lag phase from < 1 day to > 12 days during subsequent storage on ice (0–1 °C) of minced or intact co-products, respectively, even when the antioxidant solutions were re-used up to 10 times. The dipping also reduced microbiological growth and total volatile basic nitrogen, but the effect became weaker with an increased number of re-using cycles. The presented dipping strategies could hereby facilitate more diversified end use of herring co-products from current fish meal to high-quality minces, protein isolates, or oils for the food industry.
Is it only the university they are satisfied with? – Foreign student satisfaction and its effect on loyalty
Authors: Kéri Anita , Hetesi Erzsébet 
Published: October 2021

AbstractInternationalization has been in the center of research interest in the past decades. With the increasing number of students studying abroad, there has been a growing need for higher education institutions to understand foreign student satisfaction and loyalty. Therefore, the aim of this paper is to distinguish between university- and non-university-related factors accountable for foreign student satisfaction, and to highlight the effect of non-university related factors on overall foreign student satisfaction and loyalty. A clear distinction made between foreign students based on the reason for their loyalty is also studied. The proposed theoretical model is examined with structural equation modeling (SEM) and with the method of partial least squares (PLS). Results show that both university-related and non-university-related satisfaction influence foreign student loyalty. Loyalty of foreign students could be distinguished between. Examined foreign students were proven to be loyal towards either the university, the study abroad experience or none of the above.
Campylobacteriose — eine zoonotische Infektionskrankheit
Authors: Alter Thomas , Bereswill Stefan , Backert Steffen 
Published: October 2021

AbstractCampylobacter jejuni represents an important zoonotic pathogen that is causing foodborne enteric infections. In the human gut, C. jejuni bacteria induce intestinal campylobacteriosis which can develop into systemic post-infectious sequelae such as Guillain-Barré syndrome or rheumatoid arthritis. Here, we review the pathobiology and molecular mechanisms of C. jejuni infections as well as promising strategies to combat campylobacteriosis within the “One World — One Health” approach.
Rotlicht-gesteuerter viraler Gentransfer mit Einzelzellauflösung
Authors: Hörner Maximilian , Weber Wilfried 
Published: October 2021

AbstractAvailable methods for efficient gene transfer into user-selected or even single cells suffer from high invasiveness or the need for complicated equipment. Here, we present a technology for the light-guided transduction of native cell lines and primary cells by adeno-associated viral (AAV) vectors. We demonstrate the spatially resolved transduction of different cells with different genes within one culture and the selective transduction of single cells by local illumination.
Dynamische Peptidvesikel als Vorstufe synthetischer Zellen?
Authors: Pirzer Tobias 
Published: October 2021

AbstractCompartmentalization and spatial control of biochemical reactions are essential for the creation of artificial cellular systems. But it is notoriously difficult to implement reaction networks and membrane building blocks in vitro. In this article, we briefly highlight our work on the formation of peptide-based vesicles as artificial cell precursors with a size of up to 100 µm These cell mimics are able to produce RNA aptamers and proteins at the inside, and are further capable of strong growth.
Automation der Bestimmung von Vitamin D in Serum und Plasma
Authors: Thurow Kerstin , Fleischer Heidi , Bach Anna 
Published: October 2021

AbstractVitamins play an important role in many processes in the human organism. The detection of insufficient supply of vitamins is therefore of particular importance to avoid significant effects for human health. An increasing number of tests is only possible with suitable automated procedures. For the determination of vitamin D3 and vitamin D2 in serum samples, three methods were automated and compared with regard to their performance. All three methods enable reliable detection of 25(OH)D2 and 25(OH)D3 in serum in the ng/ml range.
Eine rekombinante Produktionsplattform für Peptide
Authors: Nguyen Bach-Ngan , Schmitt Lutz , Schwarz Christian 
Published: October 2021

AbstractThe production of peptides as active pharmaceutical ingredients (APIs) by recombinant technologies is of emerging interest. A reliable production platform, however, is still missing due to inherent peptide characteristics such as proteolytic sensitivity, aggregation, and cytotoxicity. We developed a new approach — Numaswitch™. It solves present limitations and provides a cost-efficient production platform for diverse peptides and hard-to-be-expressed proteins.
Synthetische Glykobiotechnologie
Authors: Rexer Thomas , Son Tuan Hoang , Ruhnau Johannes , Reichl Udo 
Published: October 2021

AbstractThe field of synthetic glycobiotechnology encompasses the synthesis and modification of free carbohydrates and carbohydrates linked to biomolecules. Our group develops bio-catalytic processes for the synthesis of carbohydrate building blocks, so-called sugar nucleotides, and cell-free multi-enzyme cascades to tailor carbohydrates linked to proteins. The technology can eventually help to advance our understanding of the roles of specific carbohydrates in nutrition and medicine and contribute to human health and well-being.
6q deletion is frequent but unrelated to patient prognosis in breast cancer
Authors: Lebok Patrick , Bönte Hannah , Kluth Martina , Möller-Koop Christina , Witzel Isabell , Wölber Linn , Paluchowski Peter , Wilke Christian , Heilenkötter Uwe , Müller Volkmar , Schmalfeldt Barbara , Simon Ronald , Sauter Guido , Terracciano Luigi , Krech Rainer Horst , von der Assen Albert , Burandt Eike 
Published: October 2021

Abstract
Background
Deletions involving the long arm of chromosome 6 have been reported to occur in breast cancer, but little is known about the clinical relevance of this alteration.

Methods
We made use of a pre-existing tissue microarray with 2197 breast cancers and employed a 6q15/centromere 6 dual-labeling probe for fluorescence in situ (FISH) analysis

Results
Heterozygous 6q15 deletions were found in 202 (18%) of 1099 interpretable cancers, including 19% of 804 cancers of no special type (NST), 3% of 29 lobular cancers, 7% of 41 cribriform cancers, and 28% of 18 cancers with papillary features. Homozygous deletions were not detected. In the largest subset of NST tumors, 6q15 deletions were significantly linked to advanced tumor stage and high grade (p < 0.0001 each). 6q deletions were also associated with estrogen receptor negativity (p = 0.0182), high Ki67 proliferation index (p < 0.0001), amplifications of HER2 (p = 0.0159), CCND1 (p = 0.0069), and cMYC (p = 0.0411), as well as deletions of PTEN (p = 0.0003), 8p21 (p < 0.0001), and 9p21 (p = 0.0179). However, 6q15 deletion was unrelated to patient survival in all cancers, in NST cancers, or in subsets of cancers defined by the presence or absence of lymph-node metastases.

Conclusion
Our data demonstrate that 6q deletion is a frequent event in breast cancer that is statistically linked to unfavorable tumor phenotype and features of genomic instability. The absence of any prognostic impact argues against a clinical applicability of 6q15 deletion testing in breast cancer patients.