bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Experience With a Shape Memory Polymer Peripheral Vascular Embolisation Plug: A Case Series
Authors: Morgan Robert A. , Loftus Ian , Ratnam Lakshmi , Das Raj , Mailli Leto , Hamady Mohamad , Lobotesis Kyriakos 
Published: February 2021

Abstract
Background: Shape memory polymers are materials that are manufactured in a certain shape, can be stored in a temporary deformed shape, and then return to – or remember – their original shape upon exposure to external stimuli such as temperature and moisture. This property lends itself to application in endovascular medical devices. Peripheral vasculature embolisation devices incorporating this novel technology have become commercially available and this case series, where the data were collected as part of a post market registry, outlines initial clinical experience with these novel devices.Results: Eight cases are described in this series. The disease state/conditions for which embolisation was indicated were right common iliac artery aneurysms (n = 3), a type II endoleak into the thoracic aorta following thoracic endovascular aneurysm repair (n = 1), a left inferior gluteal artery aneurysm (n = 1), left internal iliac artery aneurysms (n = 2), and a case of splenomegaly, where splenectomy was planned after the embolisation procedure (n = 1). Target arteries were 5-10 mm in diameter. In each case, at least one IMPEDE Embolization Plug of an appropriate diameter was used. All procedures were technically successful and target vessel thrombosis was achieved in all cases. Follow-up imaging available during the 45-90-day data collection timeframe showed sustained vessel occlusion. This case series includes examples of situations commonly encountered when embolising the peripheral vasculature, namely, the use of one or multiple devices in a single vessel and in combination with the use of other embolic devices (e.g., microcoils, gelatin sponge, and PVA particles) in the same case. There were no adverse events related to the specific use of the device.Conclusions: This small series illustrates the safety and efficacy of this novel sponge-based embolic device for the embolisation of small and medium sized arteries and further experience will demonstrate the utility of the shape memory polymer devices.
An Alternative Electrochemical Approach to Detect 4-Nitrophenylhydrazine With ZnO/SnO2 Nanoparticles Decorated Glassy Carbon Electrode
Authors: Alam Md Mahmud , Uddin M.T. , Rahman Mohammed M. , Asiri Abdullah M. , Islam M.A. 
Published: February 2021

Abstract
The 4-NPHyd (4-nitrophenylhydrazine) electrochemical sensor assembled using wet-chemically prepared ZnO/SnO2 nanoparticle (NPs) decorated a glassy carbon electrode (GCE) with conductive Nafion binder. The synthesized NPs characterized by XPS, ESEM, EDS, and XRD analysis. The calibration of the proposed sensor obtained from current versus concentration of 4-NPHyd found linear over a concentration (0.1nM~0.01mM) of 4-NPHyd, which denoted as the dynamic range (LDR) for detection of 4-NPHyd. The 4-NPHyd sensor sensitivity calculated using the LDR slope considering the active surface of GCE (0.0316 cm2), which is equal to be 7.6930 µAµM-1cm-2, an appreciable value. The detection limit (LOD) at signal/noise (S/N=3) estimated, and outstanding lower value at 94.63±4.73 pM perceived. The analytical parameters such as reproducibility, long-term performing ability and response time are found as appreciable. Finally, the projected sensor shows exceptional performances in the detection of 4-NPHyd in environmental samples.
A Histopathological Scoring and Grading System for Renal Non-aa Amyloidosis: Prediction of Clinical Manifestations and Outcomes&nbsp;
Authors: Celtik Aygul , Sen Sait , Karadag Fatma Keklik , Saydam Guray , Asci Gulay , Sarsik Banu , Ozkahya Mehmet , Toz Huseyin 
Published: February 2021

Abstract
Background: Kidney involvement is a common manifestation that contributes to morbidity and mortality in systemic amyloidosis. Amyloid load can be predicted by histopathological grading of amyloid deposits in kidney biopsy specimens. Our aim was to determine the relationship of renal amyloid deposition grade with clinical manifestations and outcomes in patients with biopsy proven renal non-AA amyloidosis. Methods: This retrospective cohort study included 74 subjects with renal non-AA amyloidosis (52 AL amyloidosis and 22 unclassified amyloidosis). Baseline characteristics and follow-up data were recorded. Pattern and quantity of amyloid deposition in glomeruli, interstitium, vessels and tubulointerstitial changes were scored. Renal Amyloid Prognostic Score (RAPS) was obtained by addition of all scores and divided into three grades (RAPS grade I, II, III). Results: In AL amyloidosis group, median follow-up was 11 (4-45 months). Among 52 patients, 17 received autologous stem cell transplantation and 29 received bortezomib based chemotherapy. Baseline eGFR was significantly lower among patients with RAPS grade III. Renal survival was significantly lower among patients with RAPS grade III. Patient survival was not significantly different according to RAPS grade. Type of amyloid could not be determined in 22 patients. In this group, baseline eGFR was significantly lower in patients with RAPS grade III. Conclusions: In patients with AL amyloidosis, baseline kidney functions are associated with RAPS grade. Renal survival is significantly lower in patients with highest RAPS grade. However, patient survival is not significantly different according to RAPS grade.
Differential expression of related molecules after acute injury of rabbits’ anterior cruciate ligament and medial collateral ligament
Authors: Wen Yu , Han Yin-he , Gu Huining , Zhang Mingzheng , Li Bin 
Published: February 2021

Abstract
Objective: This study aimed to assay expression of the mRNA and proteins for injuring- and angiogenesis-associated molecules at 3 days, 1week, 2weeks, 4weeks and 6 weeks after anterior cruciate ligament or medial collateral ligament injury in male New Zealand White rabbits.Methods: Models similar to those of clinical patients were used to establish acute partial injuries of the anterior cruciate ligament and medial collateral ligament at 3 days, 1 week, 2 weeks, 4 weeks and 6 weeks and normal control groups. Molecular biological changes in male rabbits were detected at different time points after anterior cruciate ligament and medial collateral ligament injury by H&E staining, reverse transcriptase chain reaction and westren blotting.Results: Marked differences were found in the postinjury changes in gene levels and proteins in the anterior cruciate ligament compared to the medial collateral ligament. There was no increase in mRNA expression of TIMP3, TGF-βand PRG4 in the injured anterior cruciate ligament at any time point. However, the levels of these genes tended to increase in the injured medial collateral ligament. In contrast, MMP-13 mRNA levels were significantly increased in the injured anterior cruciate ligament, but not in the medial collateral ligament. Furthermore, vascular endothelial growth factor decreased following injury to both the anterior cruciate ligament and medial collateral ligament, with the difference being a slight decrease in the medial collateral ligament and a significant decrease in the anterior cruciate ligament. Similarly, protein blots showed higher protein expression of type I and type III collagen in the injured medial collateral ligament than in the anterior cruciate ligament.Conclusion: The results show that there were drastic differences in angiogenesis, collagen and Matrix metalloproteinases after anterior cruciate ligament and medial collateral ligament injury. It can be found that the repair ability of the anterior cruciate ligament and medial collateral ligament after injury may be related to the differences in molecular expression.
A Novel FLT3 Y842D Mutation Carriers a Potentially Highly Sensitivity to Midostaurin? Case Report and Literature Review
Authors: Shujiao He , minjie Zhang , jieying Li , weiqiang Zhao , li Yu , yanbin Pang 
Published: February 2021

Abstract
Background: Y842D mutation in the activation loop of FLT3 caused a strong resistance to Sorafenib in vitro, whether this kind of mutation would exert clinical significance on acute myeloid leukemia (AML) patients remain to be clarified.Case presentation: Here, we described a novel type of activating mutation (Y842D) within the kinase domain of FLT3 in a pregnancy with de novo acute myeloid leukemia. Following induction failure with standard dose of idarubicin and cytarabine (IA), the patient received a re-induction combined with midostaurin, a promising agent targeting mutant-FLT3, and IA regimen. Fortunately, morphological remission was achieved. During the period of midostaurin treatment, the patient exhibited a symptom which was quite similar to the differentiation syndrome which disappeared following the treatment with methylprednisolone. Conclusions: Clinically, we showed for the first time that Y842D, a novel activating mutation in the activation loop of FLT3, tend to be a sensitive mutation form to midostaurin in acute myeloid leukemia patients.
Taxonomic Revision of the Genus Lactifluus (Russulales, Basidiomycota) of South Korea
Authors: Lee Hyun , Wissitrassameewong Komsit , Park Myung Soo , Fong Jonathan J. , Verbeken Annemieke , Kim Changmu , Lim Young Woon 
Published: February 2021

Abstract
Lactifluus (Pers.) Roussel is an ectomycorrhizal genus that was recently recognized to be distinct from the genus Lactarius. To date, 216 Lactifluus species have been reported worldwide. Misidentification of Lactifluus species is common because of intraspecific morphological variation, cryptic diversity, and the limited number of taxonomic keys available. Molecular data are indispensable for species delimitation; a multilocus phylogenetic analysis showed that most Asian Lactifluus species are not conspecific with morphologically similar species present on other continents. In particular, Korea has misused European and North American Lactifluus names. In this study, we evaluated the taxonomy of Lactifluus in Korea using both morphological and multilocus molecular (ITS, nrLSU, rpb1, and rpb2) data. We examined 199 Lactifluus specimens collected between 1980 and 2016, and a total of 24 species across the four Lactifluus subgenera were identified. All Korean species are distinct and clearly separated from European and North American species. Five taxa corresponded to previously described species from Asia and the remaining 19 taxa are confirmed as new species. Herein, we provide keys to the Korean Lactifluus species within their subgenera, molecular phylogenies, a summary of diversity, and detailed description of the new species.
Evaluation of Antioxidant Extraction by Microwave Treatment from Japanese Indigo Plant
Authors: Suzuki Akihiro , Nakamura Yoshitoshi , Asada Chikako 
Published: February 2021

Abstract
Tadeai (Awa-ai) is an indigo plant that is produced in large quantities in Tokushima prefecture, Japan. The leaves of Tadeai are used for dyeing (Ai-zome), but there is no use for the other parts, i.e. flowers, stems, leaves, and roots, most of which are discarded. In this study, we search for new ways to use Tadeai including parts other than the leaves and examined the antioxidant activity of water soluble extract from Tadeai. To extract antioxidants efficiently, processing was undertaken using a microwave irradiation device. The evaluation of Tadeai extract and its antioxidant activity was performed by measuring the amount of phenolic compounds by the Folin–Ciocalteu method and the DPPH radical scavenging activity test. Compared to the sample that was not subjected to microwave treatment, the amount of phenolic compounds was observed to be double, and the antioxidant activity eight times higher. The microwave treatment conditions that showed the best results are 200 ℃ and 1 min, and the evaluation indicated that the part that exhibits the best results is the root. Furthermore, the differences among Tadeai varieties were also examined. The best result was for the “Kojoko Akahana;” the root of the “Kojoko Akahana” exhibited the highest antioxidant effect. Its amount of phenolic compounds and EC50 value were 44.1 mg-catechin equiv./g-dry sample and 0.018 g/L, respectively. In this study, it was shown that the antioxidant activity of the parts other than the leaves is high, so it is expected that Tadeai waste will be effectively utilized as a raw material for producing antioxidants in the future.
Multiple-Mode Bowtie Cavities for Refractive Index and Glucose Sensors Working in Visible and Near-Infrared Wavelength Range
Authors: Chau Yuan-Fong Chou 
Published: February 2021

Abstract
A multiple-mode metal-insulator-metal plasmonic sensor with four coupled bowtie resonators containing two pair of silver baffles is numerically investigated using the finite element method and verified by the temporal coupled-mode theory. The proposed structure can function as the plasmonic refractive index and glucose sensors working in visible and near-infrared wavelength range. Simulation results show that introducing the silver baffles in bowtie cavities can modify the plasmon resonance modes and give a tunable way to enhance the sensitivity and figure of merit. The highest sensitivity (S) can reach S=1500.00, 1400.00, and 1100.00 nm/RIU and the high figure of merit (FOM) of 50.00, 46.67, and 36.67 RIU-1 from mode 1 to mode 3. The sensitivity obtained from three modes with operating wavelengths in visible and near-infrared simultaneously exceeds 1100.00 nm/RIU along with remarkably high FOM, which are not attainable from other reported literature. The proposed structure can realize multi-mode and shows impressive practical prospects that can be applied for integrated optics circuits (IOCs) and other nanophotonics devices.
Valorization of Date Syrup by the Production of Lipopeptide Biosurfactants by a Bacillus mojavensis BI2 strain: Bioprocess Optimization by Response Surface Methodology and Study of Surface Activities
Authors: Inès Mnif , Bouallegue Amir , Mekki Salwa , Ghribi Dhouha 
Published: February 2021

Abstract
Lipopeptides Biosurfactants are natural surface-active compounds produced by a variety of microorganisms. They have great interest in environmental, biomedical and agro-industrial fields. However, the high cost of culture media and the low yield of production limit their large-scale production and application. The development of efficient and cost-effective bioprocess became of a great interest for the improvement of the yield of biosurfactants and the decrease of production cost. In this aim, we applied the response surface method to optimize an economic biosurfactant production by a newly isolated strain B. mojavensis BI2 on date syrup called “Luegmi” as unique carbon and nitrogen source. Using a Box-Bhenken design, we studied the effect of three independent variables on lipopeptide production; Leugmi concentration, Na 2 HPO 4 and incubation time. The results of this study showed that Leugmi concentration at 25%, Na 2 HPO 4 at 0.1% and incubation time of 24 hours were optimal conditions for biosurfactant production, with a maximum surface tension decreasing capacity of 55% corresponding to 27 mN/m and oil dispersing of 30 cm 2 corresponding to a diameter of 6 cm. Preliminary characterization of the biosurfactant produced on Luegmi by UV-Spectra and Thin Layer Chromatography showed its lipopeptide characters. Physic-chemical characterization of the produced lipopepetide on Leugmi showed its great surface activities and stabilities at different pH, temperature and salts concentration. The results of this study suggested that Leugmi, an agricultural byproducts can be used as a low-cost substrate to enhance the yield of lipopeptide biosurfactants with great surface activities for potential environmental application.
Facile Synthesis Mn2O3 Nanorod Arrays: A Significant Material for Supercapacitor Electrode Application
Authors: Amirtharaj S Nelson , Mariappan M. 
Published: February 2021

Abstract
Mn2O3 is a significant candidate for various applications. In the present work, the Mn2O3 nanorod arrays have been successfully prepared through facile sonochemical method with the aid of cetyl trimethyl ammonium bromide (CTAB) template. The crystalline phase and bonding properties have ben confirmed through X-ray diffraction analysis (XRD) and Fourier transform infrared (FTIR) spectroscopic analysis. The electrochemical properties were analysed through various techniques such as cyclic voltammetric and galvanostatic charge/discharge analysis. Interestingly, cyclic voltammetric (CV) curves confirms the electric double layer capacitor-based charge storage mechanism and it render the maximum specific capacitance of 647 Fg-1 at a scan rate 5 mVs-1 whereas the galvanostatic charge/discharge studies offer the specific capacitance of 656 Fg-1 at a current density of 1 Ag-1. The Mn2O3 nanorod arrays provide the maximum energy and power densities of 91.1 Wh Kg-1 and 14985 Wkg-1 respectively. In addition, the cyclic stability analysis exhibit only 12 % initial capacitance degradation over 3000 CV cycles at a scan rate of 100 mVs-1. The hopeful outcomes demonstrate the significant of the Mn2O3 nanorod arrays as electrode material for supercapacitor devices.
Senecio pseudoarnica Less. (Asteraceae) – a new non-native species invading coastal areas in arctic and subarctic Europe
Authors: Wasowicz Pawel , Alm Torbjørn 
Published: February 2021

Abstract
We report the human-assisted spread of Senecio pseudoarnica, native to the northern coasts of North America and the Far East, to arctic and subarctic regions of Europe. Our findings indicate that the species, imported as a decorative plant, is currently rapidly spreading along coastal areas of Iceland and Norway. An exponential model comprehensively explained the increase in the number of known localities. Close climate matching between the native and non-native ranges (shown by our preliminary analyses), as well as practically exact environmental matching, are the main factors that facilitate the process of naturalisation and invasion. S. pesudoarnica is one of the very few species invading these arctic and subarctic regions.
Precise detection of the germinomatous component of intracranial germ cell tumors of the basal ganglia and thalamus using placental alkaline phosphatase in cerebrospinal fluid
Authors: Chiba Kentaro , Aihara Yasuo , Kawamata Takakazu 
Published: February 2021

Abstract
Purpose: The disadvantages of biopsy for lesions in the basal ganglia and thalamus include a risk of various complications, difficulty in selecting the target tissue in some cases due to indistinct neuroimaging findings and limited availability of sample tissue. Placental alkaline phosphatase (PLAP) plays a decisive role in the diagnosis and management of intracranial germ cell tumors (IGCTs) in the basal ganglia and thalamus. The present study aimed to demonstrate the ability, specificity, and optimal use of PLAP values obtained from cerebrospinal fluid (CSF).Methods: Twenty patients with lesions in the basal ganglia and thalamus were enrolled in this study: 11 had IGCTs and 9 had non-IGCTs. The values of PLAP and other established tumor markers in the CSF were measured in all patients before treatment.Results: The mean follow-up period was 76.0 months (range, 3–168) for all lesions. PLAP was elevated in all 11 patients with IGCTs in the basal ganglia or thalamus, whereas none of the patients with non-IGCT exhibited elevated PLAP. Thus, the sensitivity and specificity of PLAP were both 100%.Conclusion: Our data demonstrated that the PLAP value can specifically identify the germinomatous component even in cases of IGCTs in the basal ganglia or thalamus with high sensitivity and specificity. PLAP is undoubtedly beneficial for the safe and timely detection of the germinomatous component of IGCTs in the basal ganglia and thalamus, because reliance on PLAP measurement enables us to avoid invasive surgical procedures and facilitates the prompt initiation of chemoradiation therapy.
Model-based Design and Simulation of a Soft Robotic Gripper for Fabric Material Handling
Authors: Wang Bowen , Urbanic Ruth Jill 
Published: February 2021

Abstract
Fabric and textile materials are widely used in many industrial applications, especially in automotive, aviation, and consumer goods. Currently, there is a lack of automatic solutions for rapid and effective fabric handling operations that can be expanded to various applications, causing economic loss, workplace safety issues, and process bottlenecks. As a bio-inspired novel technology, soft robotic grippers provide new opportunities for the automation of fabric handling tasks. In this research, an elastomer-based tendon-actuated soft gripper for fabric pick and place tasks is developed through a model-based design approach. Based on finite element analysis, the gripper design is simulated, modified, and validated. Multiple design variables and their impacts are studied. Detailed motion patterns of the underactuated structure are obtained. After the design is established, a prototype is fabricated trough additive manufacturing and overmolding processes to physically test the functionality of the gripper and further validate the simulation results.
Knowledge Regarding Drug Abuse among School Students
Authors: Yadav Poonam Kumari , Parajuli Rejina 
Published: February 2021

Abstract
Objectives: The aim of this study was to assess the level of knowledge regarding drug abuse among the school students. Materials and Methods: A descriptive cross sectional study design was used. 106 samples were selected randomly from grade IX and X of Shree Janak Secondary School. Self-administered structured knowledge questionnaire was used for data collection. Descriptive statistics was used to calculate percentage and frequency. The chi square test was used to find association between selected demographic variable and level of knowledge. P value of 0.05 was considered significant. Results: 99.1% of the respondents heard about drug abuse, 97.9% said drug abuse is bad for health, 96.2% said Gaja is commonly available, 51.9% said high chance of getting HIV with drug abuse, 67% said financial burden as cause, 60.4% said drug abuser performed poorly at school work, 71.7% said awareness program as the way to prevent from drug abuse and 26.4% said counselling. Similarly, 52.8% said rehabilitation is the way to treat drug abuse, 88.7% said dependence to drug as the long term complication of drug abuse. Majority 57.5% had poor, 41.5% have adequate and 0.9% had good level of knowledge regarding drug abuse. Conclusion: Half of the respondents had poor knowledge regarding drug abuse and level of knowledge is significantly higher for Brahmin/Chhetri and poor for Janajati, Dalit and Madhesi.