bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tislelizumab for Relapsed/Refractory Classical Hodgkin Lymphoma: 3-Year Follow-up and Correlative Biomarker Analysis
Authors: Song Yuqin , Gao Quanli , Zhang Huilai , Fan Lei , Zhou Jianfeng , Zou Dehui , Li Wei , Yang Haiyan , Liu Ting , Wang Quanshun , Lv Fangfang , Guo Haiyi , Zhao Xia , Wang Dan , Zhang Pei , Wang Yidi , Wang Lei , Liu Tengfei , Zhang Yun , Shen Zhirong , Huang Jane , Zhu Jun 
Published: October 2021

Abstract

Purpose:
Tislelizumab is an anti–programmed cell death protein 1 (anti–PD-1) monoclonal antibody specifically designed to minimize binding to Fcγ receptors (FcγR).

Patients and Methods:
Here, we present the extended 3-year follow-up of a phase II study of tislelizumab in 70 patients with relapsed/refractory classical Hodgkin lymphoma (cHL) who failed or were ineligible for autologous stem cell transplantation.

Results:
With a median follow-up of 33.8 months, the overall response rate by the independent review committee was 87.1%, and the complete response (CR) rate was 67.1%. Responses were durable as shown by a median duration of response of 31.3 months, and median progression-free survival (PFS) of 31.5 months. The 3-year PFS and overall survival rates were 40.8% and 84.8%, respectively. Treatment-related adverse events (TRAEs) of any grade occurred in 97.1% of patients; the grade ≥3 TRAE rate was low (31.4%), and only 8.6% of patients experienced adverse events leading to treatment discontinuation. Correlative biomarker analysis showed that FcγRΙ-expressing macrophages had no observed impact on either the CR rate or PFS achieved with tislelizumab, which may be potentially related to its engineered Fc region.

Conclusions:
With extended follow-up, tislelizumab yielded long-term benefits and demonstrated a favorable safety profile for patients with relapsed/refractory cHL. This trial was registered at clinicaltrials.gov as NCT03209973.
Sex-Specific Clinical Outcomes of the PACT-HF Randomized Trial
Authors: Van Spall Harriette G.C. , DeFilippis Ersilia M. , Lee Shun Fu , Oz Urun Erbas , Perez Richard , Healey Jeff S. , Allen Larry A. , Voors Adriaan A. , Ko Dennis T. , Thabane Lehana , Connolly Stuart J. 
Published: October 2021

Background:
Transitional care may have different effects in males and females hospitalized for heart failure. We assessed the sex-specific effects of a transitional care model on clinical outcomes following hospitalization for heart failure.

Methods:
In this stepped-wedge cluster randomized trial of adults hospitalized for heart failure in Ontario, Canada, 10 hospitals were randomized to a group of transitional care services or usual care. Outcomes in this exploratory analysis were composite all-cause readmission, emergency department visit, or death at 6 months; and composite all-cause readmission or emergency department visit at 6 months. Models were adjusted for stepped-wedge design and patient age.

Results:

Among 2494 adults, mean (SD) age was 77.7 (12.1) years, and 1258 (50.4%) were female. The first composite outcome occurred in 371 (66.3%) versus 433 (64.1%) males (hazard ratio [HR], 1.04 [95% CI, 0.86–1.26];
P
=0.67) and in 326 (59.9%) versus 463 (64.8%) females (HR, 0.83 [95% CI, 0.69–1.01];
P
=0.06) in the intervention and usual care groups, respectively (
P
=0.012 for sex interaction). The second composite outcome occurred in 357 (63.8%) versus 417 (61.7%) males (HR, 1.03 [95% CI, 0.85–1.24];
P
=0.76) and 314 (57.7%) versus 450 (63.0%) females (HR, 0.81 [95% CI, 0.67–0.99];
P
=0.037) in the intervention and usual care groups, respectively (
P
=0.024 for sex interaction). The sex differences were driven by a reduction in all-cause emergency department visits among females (HR, 0.66 [95% CI, 0.51–0.87];
P
=0.003), but not males (HR, 1.10 [95% CI, 0.85–1.43];
P
=0.46), receiving the intervention (
P
<0.001 for sex interaction).

Conclusions:
A transitional care model offered a reduction in all-cause emergency department visits among females but not males following hospitalization for heart failure.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02112227.
Successful Reduction of Postoperative Chest Tube Duration and Length of Stay After Congenital Heart Surgery: A Multicenter Collaborative Improvement Project
Authors: Bates Katherine E. , Connelly Chloe , Khadr Lara , Graupe Margaret , Hlavacek Anthony M. , Morell Evonne , Pasquali Sara K. , Russell Jennifer L. , Schachtner Susan K. , Strohacker Courtney , Tanel Ronn E. , Ware Adam L. , Wooton Sharyl , Madsen Nicolas L. , Kipps Alaina K. 
Published: October 2021

Background
Congenital heart disease practices and outcomes vary significantly across centers, including postoperative chest tube (CT) management, which may impact postoperative length of stay (LOS). We used collaborative learning methods to determine whether centers could adapt and safely implement best practices for CT management, resulting in reduced postoperative CT duration and LOS.

Methods and Results

Nine pediatric heart centers partnered together through 2 learning networks. Patients undergoing 1 of 9 benchmark congenital heart operations were included. Baseline data were collected from June 2017 to June 2018, and intervention‐phase data were collected from July 2018 to December 2019. Collaborative learning methods included review of best practices from a model center, regular data feedback, and quality improvement coaching. Center teams adapted CT removal practices (eg, timing, volume criteria) from the model center to their local resources, practices, and setting. Postoperative CT duration in hours and LOS in days were analyzed using statistical process control methodology. Overall, 2309 patients were included. Patient characteristics did not differ between the study and intervention phases. Statistical process control analysis showed an aggregate 15.6% decrease in geometric mean CT duration (72.6 hours at baseline to 61.3 hours during intervention) and a 9.8% reduction in geometric mean LOS (9.2 days at baseline to 8.3 days during intervention). Adverse events did not increase when comparing the baseline and intervention phases: CT replacement (1.8% versus 2.0%,
P
=0.56) and readmission for pleural effusion (0.4% versus 0.5%,
P
=0.29).

Conclusions
We successfully lowered postoperative CT duration and observed an associated reduction in LOS across 9 centers using collaborative learning methodology.
Differences in Left Atrial Size and Function and Supraventricular Ectopy Between Black and White Participants in the ARIC Study
Authors: Wang Wendy , Norby Faye L. , Zhang Michael J. , Reyes Jorge L. , Shah Amil M. , Soliman Elsayed Z. , Lutsey Pamela L. , Alonso Alvaro , Solomon Scott D. , Inciardi Riccardo M. , Chen Lin Y. 
Published: October 2021

Background
Black Americans have more atrial fibrillation risk factors but lower atrial fibrillation risk than White Americans. Left atrial (LA) enlargement and/or dysfunction, frequent atrial tachycardia (AT), and premature atrial contractions (PAC) are associated with increased atrial fibrillation risk. Racial differences in these factors may exist that could explain the difference in atrial fibrillation risk.

Methods and Results
We included 2133 ARIC (Atherosclerosis Risk in Communities) study participants (aged 74±4.5 years[mean±SD], 59% women, 27% Black participants) who had echocardiograms in 2011 to 2013 and wore the Zio XT Patch (a 2‐week continuous heart monitor) in 2016 to 2017. Linear regression was used to analyze (1) differences in AT/day or PAC/hour between Black and White participants, (2) differences in LA measures between Black and White participants, and (3) racial differences in the association of LA measures with AT or PAC frequency. Compared with White participants, Black participants had a higher prevalence of cardiovascular risk factors and disease, lower AT frequency, greater LA size, and lower LA function. After multivariable adjustments, Black participants had 37% (95% CI, 24%–47%) fewer AT runs/day than White participants. No difference in PAC between races was noted. Greater LA size and reduced LA function are associated with more AT and PAC runs; however, no race interaction was present.

Conclusions
Differences in LA measures are unlikely to explain the difference in atrial fibrillation risk between Black and White individuals. Despite more cardiovascular risk factors and greater atrial remodeling, Black participants have lower AT frequency than White participants. Future research is needed to elucidate the protective mechanisms that confer resilience to atrial arrhythmias in Black individuals.
Role of Renal Sympathetic Nerves in GLP‐1 (Glucagon‐Like Peptide‐1) Receptor Agonist Exendin‐4‐Mediated Diuresis and Natriuresis in Diet‐Induced Obese Rats
Authors: Liu Xuefei , Patel Kaushik P. , Zheng Hong 
Published: October 2021

Background
The gut‐derived hormone GLP‐1 (glucagon‐like peptide‐1) exerts beneficial effects against established risk factors for chronic kidney disease. GLP‐1 influences renal function by stimulating diuresis and natriuresis and thus lowering arterial blood pressure. The role of the sympathetic nervous system has been implicated as an important link between obesity with elevated arterial pressure and chronic kidney disease. The primary aim of this study was to determine the contribution of renal sympathetic nerves on intrapelvic GLP‐1‐mediated diuresis and natriuresis in high‐fat diet (HFD)‐induced obese rats.

Methods and Results

Obesity was induced in rats by HFD for 12 weeks, followed by either surgical bilateral renal denervation or chronic subcutaneous endopeptidase neprilysin inhibition by sacubitril for a week. Diuretic and natriuretic responses to intrapelvic administration of the GLP‐1R (GLP‐1 receptor) agonist exendin‐4 were monitored in anesthetized control and HFD rats. Renal GLP‐1R expression and neprilysin expression and activity were measured. The effects of norepinephrine on the expression of GLP‐1R and neprilysin in kidney epithelial LLC‐PK1 cells were also examined. We found that diuretic and natriuretic responses to exendin‐4 were significantly reduced in the HFD obese rats compared with the control rats (cumulative urine flow at 40 minutes, 387±32 versus 650±65 µL/gkw; cumulative sodium excretion at 40 minutes, 42±5 versus 75±10 µEq/gkw,
P
<0.05). These responses in the HFD rats were restored after ablation of renal nerves (cumulative urine flow at 40 minutes, 625±62 versus 387±32 µL/gkw; cumulative sodium excretion at 40 minutes, 70±9 versus 42±5 µEq/gkw,
P
<0.05). Renal denervation induced significant reductions in arterial pressure and heart rate responses to intrapelvic GLP‐1 in the HFD rats. Renal denervation also significantly increased the GLP‐1R expression and reduced neprilysin expression and activity in renal tissues from the HFD rats. Chronic subcutaneous neprilysin inhibition by sacubitril increased GLP‐1–induced diuretic and natriuretic effects in the HFD rats. Finally, exposure of the renal epithelial cells to norepinephrine in vitro led to downregulation of GLP‐1R expression but upregulation of neprilysin expression and activity.

Conclusions
These results suggest that renal sympathetic nerve activation contributes to the blunted diuretic and natriuretic effects of GLP‐1 in HFD obese rats. This study provides significant novel insight into the potential renal nerve–neprilysin–GLP‐1 pathway involved in renal dysfunction during obesity that leads to hypertension.
Impact of Transcatheter Aortic Valve Replacement on Hospitalization Rates: Insights From Nationwide Readmission Database
Authors: Elkaryoni Ahmed , Chhatriwalla Adnan K. , Kennedy Kevin F. , Saxon John T. , Lopez John J. , Cohen David J. , Arnold Suzanne V. 
Published: October 2021

Background
Hospitalization rates after transcatheter aortic valve replacement (TAVR) remain high, given the age and comorbidities of patients undergoing TAVR. To better understand the impact of TAVR on hospitalization, we sought to compare hospitalization rates before and after TAVR and to examine if underlying patient comorbidities are associated with a differential effect of TAVR on hospitalizations.

Methods and Results

We used the Nationwide Readmissions Database to identify patients who underwent TAVR. As Nationwide Readmissions Database data do not cross over calendar years, we limited our index admission to hospitalizations during April to September of each calendar year to allow 90 days of observation before and after TAVRs. We calculated the daily risk of all‐cause hospitalization and used a mixed‐effects logistic regression model to explore interactions between patient characteristics, TAVR, and hospitalization risk. Among 39 249 patients who underwent TAVR in 2014 to 2017 (median age, 82 years [interquartile range, 76–87 years]; 45.7% women), 32.0% had at least one hospitalization in the 90 days before TAVR compared with 23.2% in the 90 days post‐TAVR (relative reduction, 27.5%;
P
<0.001). In the mixed‐effects logistic regression model, TAVR was associated with decreased all‐cause hospitalization rate after TAVR in all comorbidity subgroups. However, younger patients and those with heart failure and reduced ejection fraction appeared to have more robust reduction in hospitalizations.

Conclusions
Although patients who are treated with TAVR have high rates of rehospitalization, TAVR is associated with an overall reduction in all‐cause hospitalizations regardless of underlying patient comorbidities.
The Corporeality of the Self
Authors: Lilly Ingrid E. 
Published: October 2021

Abstract
A contribution to Western genealogies of the self, the corporeality of the Hebrew soul (nefeš) is explored through the lens of ancient medical discourses. Using the example of bitterness as an ethnomedical syndrome, this essay shows how the Hebrew idiom “bitter nefeš” acts as an embodied channel of flux in illness narratives about bodily suffering and healing.
Biblical Narrative as Ethics?
Authors: Lambert David 
Published: October 2021

Abstract
This paper considers whether biblical narrative was used as part of a technology of the self in Jewish antiquity. Many have seen the assumption that Israel’s ancestors were perfect and, hence, worthy of imitation as essential to the Bible’s identity as Scripture around the turn of the Common Era. Recently several scholars have detailed the specific dynamics of exemplarity among certain readers of the Bible, such as Philo, particularly in light of Hellenistic and Roman models. Such work draws attention to the relative lack of explicit attestation for such a practice in much of ancient Jewish literature. As a next step, we need to further delineate what constitutes a literary practice of exemplarity and explore alternatives or additions to it, such as memorialization. To do so, this paper examines a range of texts, including the Genesis Apocryphon, the Book of Jubilees, Ben Sira, Philo, Josephus, and the rabbinic collection, Genesis Rabbah.
Opportunism in Foreign Affairs in First Century BCE China: Chen Tang, His Fellows, and Their Patrons
Authors: Tse Wicky W.K. 
Published: October 2021

Abstract
By examining the career of a contingent of action-prone mid-level military officers and diplomats, this article aims to explore how opportunism functioned in foreign affairs during the last decades of the Former Han dynasty (202 BCE–9 CE). To safeguard and advance the empire’s interests, especially in Central Asia, these characters would carry out their missions with expediency, usually by the means of assassination and surprise attacks, and sometimes without formal authorization. Yet their successful operations always earned, if retrospectively, the endorsement of the imperial court, which in turn encouraged further ventures. The investigation of the front-line opportunists and their patrons presents a lively picture of the politics and political culture of the time.
Solomon’s Throne in Its Ancient Near Eastern Context
Authors: Eichler Raanan 
Published: October 2021

Abstract
The throne of Solomon, described in 1 Kgs 10:18–20 and almost identically in 2 Chr 9:17–19, is the main object relating to the visual representation of royalty in the Hebrew Bible. This paper offers a close commentary on the description and considers what type of ancient Near Eastern throne the described object exemplifies, concluding that Solomon’s throne is a “biblicized” variant of the Canaanite-Phoenician sphinx throne.
Meadow voles differentiate between scents of different sources
Authors: Garris Sarah S. , Pierson Lyndsey M. , Ferkin Michael H. 
Published: October 2021

Abstract
Scent marks are an important means of transmitting information between rodents, and they can be produced from several body sources. Previous studies have shown that scents from multiple sources can convey the same information; female meadow voles, for example, have three scent sources that communicate sex. However, possessing three separate sources that convey the same information is likely costly due to the metabolic energy required to produce these signals and the increased chance that eavesdropping individuals may intercept information present in these signals. In this study, we investigated if these scent sources could communicate other information, in addition to scent donor sex, by determining if male meadow voles could distinguish scent marks taken from different sources of a single female scent donor. This was accomplished with a habituation-test method, that allowed us to compare how male meadow voles differently investigate scent from a familiar and novel source of a female scent donor. Male meadow voles could distinguish between faeces and urine scent marks of a female, but could only distinguish mouth from urine and faeces scent marks when first familiarized with mouth scent marks. Our findings suggest that mouth, urine, and faeces scent marks of female meadow voles produce both redundant and distinct information. The overlap in information between scent marks produced from separate sources may be needed to provide social context, which allows receiving individuals to accurately weigh the tradeoffs associated with responding to an olfactory cue. While this overlap in information remains costly, this cost may be minimized by the different fade-out times of scent marks from distinct body sources, which may limit the amount of time information in a scent mark is available to a time period where this information is socially relevant.
An anecdotal observation of anti-predatory tool use in a New Zealand parrot
Authors: Burns K.C. 
Published: October 2021

Abstract
I observed a wild kākā (Nestor meridionalis) excavate a piece of deadwood from the branch it was perched on and carry it to a new position immediately above a perched predatory falcon (Falco novaeseelandiae). It then raised its head upwards, and in a single downward motion with its head, released the piece of wood towards the falcon below. The piece of wood struck the falcon in the back, which immediately took flight and disappeared from view. I conclude my description of this anecdotal observation of anti-predatory tool use with caveats and alternative interpretations.
The Lacuna of Hermeneutics: Notes on the Freedom of Thought
Authors: Schuback Marcia Sá Cavalcante 
Published: October 2021

Abstract
In this article I argue not only for the value of hermeneutics today but also, and especially, how the crucial gesture of hermeneutics is that of changing the subject for the sake of our today. Surveying briefly the main lines of hermeneutical positions along its history and critiques, and connecting these critiques to the discrepancy between theory and practice, between interpretation and the need to change the world, the article proposes that our reality today, reshaped through globalization and the virtual, is performed as a hermeneutics of history. The challenge for today’s hermeneutics is to work out categories for understanding the present as on-going in a world that tends to capture and distort more and more the meaning of freedom of thought. In the final section, I propose a hermeneutics of the on-going, of gerundive time, partially under the inspiration of Paul Celan, as a response that develops the meaning of the freedom of thought. A defense of nearness and how to think in narrow nearness to the on-going is discussed.
Toward the Reconstruction of a Sacred Landscape of the Judean Highlands
Authors: Burke Aaron A. 
Published: October 2021

Abstract
At least a dozen biblical toponyms for sites and landscape features in ancient Judah’s highlands bear divine name elements that were most common during the Middle and Late Bronze Ages. In light of archaeological evidence from many of these sites, it is suggested that they were first settled as part of a settlement influx in the highlands during the Middle Bronze Age (ca. 2000–1550 BCE), following a reemergence of urbanism and a return of economic development that occurred under Amorite aegis. The cultic orientation of these sites may be suggested by reference to ritual traditions at Mari during the Middle Bronze Age but especially Ugarit during the Late Bronze Age. Such evidence may also serve to elucidate the various enduring cultic associations that persisted in connection with these locations during the Iron Age, as preserved in various biblical traditions.
What Does Calvin’s Engagement with Acts Teach Us about God’s Providence?
Authors: Holmes Christopher R.J. 
Published: October 2021

Abstract
Calvin’s commentarial engagement with Acts makes an important contribution to understanding providence. This is, I argue, the case with respect to the important distinction between divine determination and divine permission. In this article, I unfold how the language of divine determination refers to what is true of God in a substantial sense. God’s determination reflects what God is in se. The language of permission, however, pertains only to evil. Such an inquiry advances systematic thinking on providence, encouraging recognition of how determination and permission have different referents. ‘Determination’ refers to what is of God, ‘permission’ to what is evil. The article also contributes to Calvin scholarship by showing how Calvin’s encounter with Acts generates a more expansive account of providential themes than one finds in the Institutes.
The Lord’s Supper and the Resurrection of the Body
Authors: van Eijk Ton 
Published: October 2021

Abstract
The starting point of this article is a text of Irenaeus in defense of the resurrection of the body against the Gnostics. In the very different context of the zweiter Abendmahlsstreit in the 16th century this text was part of a dossier of Patristic texts that was used by both parties, Lutheran and Reformed. One of the issues was whether the body of Christ was eaten by the mouth or by faith. It will be shown how Calvin and Heshusius understood this text. In the end it will appear that for various reasons the issue seems to have lost its relevance. With the Leuenberg Agreement the dispute was laid to rest.