bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of neoadjuvant denosumab in giant cell tumor of the bone depending of the tumor location and the surgical grade
Authors: Tararykova A. A. , Fedenko A. A. , Musaev E. R. , Sushentcov E. A. , Sofronov D. I. , Valiev A. K. , Borzov K. A. , Kabardaev R. M. , Sokolovskii A. V. 
Published: November 2021

Background. The standard treatment for giant-cell tumors of the bone includes radical surgery. However, specific anatomical location of the tumor and/or its spread may hinder its complete excision or result in poor functional outcomes. Currently, combination treatment that includes preoperative denosumab and surgery is preferable. It saves patients’ lives and improves their quality of life. Reduction of local recurrence rate by combination therapy for giant-cell tumors of the bone is being actively studied now.Objective – to analyze treatment outcomes of patients with giant-cell tumors of the bone, including those who received combination treatment that included preoperative therapy with denosumab followed by surgery.Materials and methods. This study included 277 patients with giant-cell tumors treated in N.N. Blokhin National Cancer Research Center between 2005 and 2020. The mean duration of follow-up was 56 months. Study participants were divided into two groups. Group 1 included patients who received surgical treatment alone (n = 212), whereas Group 2 comprised patients who received combination treatment (n = 65). Neoadjuvant therapy included subcutaneous denosumab 120 mg on days 1, 8, 15, and 28, then every 4 weeks until stable effect. There were two variants of surgical treatment: radical (removal by a single block or segmental resection with defect replacement, with or without fixation) and non-radical (excochleation or marginal resection with defect replacement, with or without fixation).Results. During treatment, patients in Group 2 had a significantly milder pain syndrome (assessed both using the visual analog scale for pain and Watkins scale) compared to Group 1. In case of radical surgery, the incidence of local recurrence was 12 % and 0 % in Groups 1 and 2, respectively; the difference was significant (р <0.05). Tumor location and volume of surgery played an important role in disease recurrence (р <0.05). The incidence of complications after radical surgery was 36.9 % and 12.5 % in Groups 1 and 2, respectively; the difference was significant (р <0.05). In addition to that, neoadjuvant therapy with denosumab substantially reduced the duration of surgery and blood loss in patients with challenging anatomical location of the tumor (р <0.05).Conclusion. Combination treatment for giant-cell tumors that includes neoadjuvant therapy with denosumab reduces the risk of recurrence, duration of surgery, blood loss, and the risk of postoperative complications. However, it is important to consider tumor location and the volume of surgery. Since the disease is quite rare, further study of long-term efficacy and safety of combination treatment for giant-cell tumors, including rare ones and those with challenging anatomical location, is necessary.
Neonatal septicemia and current scenario of antibiotic sensitivity pattern – A study of blood culture isolates in a tertiary care hospital, Rajkot
Authors: Mistry Madhulika , Bhattacharya Arpita , Parmar Twinkle Kumar 
Published: November 2021

Neonatal sepsis is one of the leading causes of neonatal mortality in developing countries. Neonatal sepsis can be classified into two subtypes depending upon onset of symptoms- before 72 hours of life (early-onset neonatal sepsis—EONS) or later (late-onset neonatal sepsis—LONS). Bacteriological profile and antibiotic susceptibility pattern in neonatal septicemia are changing time-to-time and place-to-place. This study is aimed to know the current scenario of neonatal septicemia and antibiotic susceptibility pattern for determining effective treatment, hence reducing burden of antibiotic resistance.This is a Retrospective study. Data was collected from Bacteriology lab, PDUMC Rajkot (May 2020 – May 2021). Blood cultures were performed on suspected neonates. Both BACTEC and conventional methods were used. Organisms were isolated by standard microbiological protocols and antibiotic sensitivity was performed by Kirby-Bauer disc diffusion method as per CLSI- 2020/2021 guidelines. Total 1402 samples were screened. 326 were positive (23.25%). 214(65.64%) were male and 112(34.36%) were female. CONS (32.21%) was found to be the predominant pathogen followed by Klebsiella (19.63%), Staphylococcus aureus (18.10%), E. coli (15.95%), Acinetobacter (12.27%) and Enterococcus spp. (1.84%). EONS was seen in 195(59.82%) cases and LONS was seen in 131(40.18%) cases. Gram-negative bacteria are predominant in EONS (76.28%) and gram-positive bacteria is predominant in LONS (64.12%). Gram negative isolates are mostly susceptible to Meropenem, Piperacillin-tazobactam, Cefepime, Ceftazidime. Gram positive isolates mostly showed sensitivity to Vancomycin, Linezolid.Multi-drug resistant organism are emerging in neonatal septicemia. Strict antibiotic stewardship should be practiced to avoid the upcoming treatment difficulties.
Study of viral markers (human immunodeficiency virus, HBsAg and anti-HCV) among pregnant women attending the antenatal clinic
Authors: Singh Sudhir , Lalman  , Najam Rehana , Farooq Umar , Sharma Shweta R , Sharma Vasundhara , Ahamad Imran 
Published: November 2021

It has been recognized that population-based surveys are needed to assess the prevalence of hepatitis C virus, hepatitis B virus and HIV infection. Pregnant women can be considered as outpost populations because they are relatively unselected populations and their prevalence data may be extended to general population.Study of viral markers (Human immunodeficiency virus, HBsAg and antiHCV among pregnant woman attending the antenatal clinic. Determination of HIV, HBsAg and HCV in the pregnant females. In this age wise distribution of HCV positive cases, five cases were positive in 17-21, age group of 22-26 twelve patients were positive, age group of 27-31 eleven patients were positive, age group of 32-36 four patients were positive and three were positive in the age above 36 years. In table number two, 7 were positive for HBsAg, 35 were positive for HCV and no one was for HIV.In our study, pregnant women had a higher HCV infection rate. Occurrence of HBsAg infection was low in expectant ladies. In our area, people were very careful because they don’t want to spread HIV in their area. The public has complied with HIV/AIDS regulations. They always used condoms and never shared needles. Hence the mother could not spread HIV to the child. In order tounderstand the reasons and inferences of these findings, and provide more guidance, other research is needed.
Detection of SARs CoV-2 during initial phase of pandemic from population of banas kantha district of Gujarat-India with special emphasis on pooled samples
Authors: Patel Hiren , Goswami Parijat N 
Published: November 2021

Corona virus (SARs CoV-2) has caused immense effect on morbidity and mortality of the population globally. We undertook this study as we are a part of one of the network laboratories of ICMR to test the patient’s sample by RT PCR for the ORF 1 ab gene of corona virus. : For a period of one and half months (14 April to 31 May 2020) we tested the nasopharynx and oro-pharynx swab samples sent to us in VTM from the assigned districts of Gujarat. All the samples were subjected to RT PCR method by following standard methods. Total of 9.04%(256/2833) population was positive and 4.73%(139/2833) belonged to age groups 21-40 and 2.33% (66/2833) to 41-60yrs. Above the age of 60yrs there were only 0.95% (22/2833) cases which were positive. It was advantageous to pool the samples. Out of the number of pools prepared, we reported around 80% negative and rest were positive in pools. The study also included association of viral load and infectivity. We found that 12% of the asymptomatic people and 5.1% of symptomatic individuals had high viral load. : It is seen that the incidence of Novel corona virus -19 detection by RT PCR is a reliable method and the establishment of the Ct value and infectivity of the patient to the health care workers and relatives needs to be taken care of. Also, the study presents asymptomatic patients having high viral loads being highly infective.
Competitive Intelligence and Resilience of Small Medium Enterprises (SMEs) in Developing Economies
Authors: Nte Ngboawaji Daniel , Omede Nduka Kenneth 
Published: November 2021

Small and Medium Enterprises SMEs hold the key to economic progress and development in developing economies including Nigeria. This study therefore examined the effect of competitive intelligence on the survival of SMEs in Benin City, Edo State, Nigeria. To achieve these objectives three hypotheses were formulated to establish whether or not there is a relationship existing between the two intervening variable i.e. competitive intelligence and the survival of SMEs in Benin City, Edo State and by extension Nigeria. Survey research design was adopted, while data were obtained from structured questionnaire and analyzed using Pearson’s product-moment coefficient of correlation. From the analysis, the results indicated that there is an existing relationship between the variables. Based on the findings it was concluded that for SMEs to survive and expand its market frontiers in the face of the escalating competition in the business environment, there is the need to take a holistic view of their strategies and offer innovative products that can provide customers with valued and satisfying benefits better than the ones offered by competitors and engaging in superior marketing strategies to enhance performance and productivity. The study recommended among others that SMEs should identify and prune down unwarranted business expenses without necessarily impacting negatively on the operations of the firm.
Keywords: Innovative Products, Performance, Productivity, Satisfying Benefits, SMEs, Survival.
Students’ Awareness of Metacognitive Reading Strategies in Academic Reading
Authors: Dangin Dangin 
Published: November 2021

<p>Being aware of reading strategies becomes the key of readers’ success in reading process, this study began with its purpose to investigate the readers’ awareness of metacognitive reading strategies while facing academic reading texts. Then, the respondents here were whole 50 students of English department, who had completed the questionnaire of Survey of Reading Strategies Awareness (SORS). Those respondents were intended to reveal the type of reading strategies used during reading academic materials in English. The results of study revealed that those respondents were aware of using two of three categories of reading strategies while reading the materials. As the detail, the results showed that the respondents mostly tended to use the strategies categorized in Problem Solving Strategies (PROB) in order to solve their obstacle in reading. Global Reading Strategies (GLOB) as second place, which is mostly used by the respondents. And the last or the lowest strategies in use are Support Strategies (SUP).</p>
The Legal, Ethical, and Scientific Considerations for Returning Explanted Orthopaedic Hardware to the Patient
Authors: Black Natalie R. , Winslade William J. , Lindsey Ronald W. , Gugala Zbigniew 
Published: November 2021

Abstract:
Orthopaedic hardware explantation is a multifaceted topic with complex legal, ethical, and scientific aspects that require thorough exploration. Issues of device ownership, explant-induced disease propagation, and potential device resale pose legal risks to providers and health-care institutions. Ethically, implant removal highlights the potential that performing procedures at the request of the patient will incentivize patient compliance and strengthen the patient-surgeon relationship. However, the return of explanted hardware to patients could hinder scientific study and innovation, ultimately limiting advancement in risk reduction and patient outcomes. Continued research into these topics remains paramount to ensure that clinicians and institutions deliver optimal patient care while abiding with legal and ethical imperatives. This article addresses the legal, ethical, and scientific issues that are pertinent to returning an explanted orthopaedic implant to the patient and the potential ramifications of such practice.
A Novel Branched Polymer Gel System with Delayed Gelation Property for Conformance Control
Authors: Song Tao , Feng Qi , Schuman Thomas , Cao Jie , Bai Baojun 
Published: November 2021

SummaryExcessive water production from oil reservoirs not only affects the economical production of oil, but it also results in serious environmental concerns. Polymer gels have been widely applied to decrease water production and thus improve oil production. However, traditional polymer gels such as partially hydrolyzed polyacrylamide (HPAM)/chromium (III) gel systems usually have a short gelation time and cannot meet the requirement of some conformance control projects. This paper introduces a novel polymer gel system of which crosslinking time can be significantly delayed. A branched polymer grafted from arginine by the surface initiation method is synthesized as the backbone, chromium acetate is used as the crosslinker, and no additional additives are used for the gel system. The results show that the gelation time of this system can be delayed to 61 days at 45°C and 20 days at 65°C because of the rigid structure of the branched polymer and the excellent chromium (III) chelating ability of arginine. The polymer gels have been stable for more than 150 days at 45 and 65°C. Coreflooding and rheology tests have demonstrated that this branched polymer has good injectivity and shear resistance in high-permeability rocks.
Modern Analogues of Sedimentation of Lower Permian Reservoirs in the Dnieper-Donets Depression
Authors: Loktyev Valentyn , Zharkeshov Sanzhar , Gotsynets Oleg , Davydenko Oleksandr , Machuzhak Mikhailo , Pavlo Kuzmenko , Repryntsev Vitalii , Kabatova Oksana 
Published: November 2021

Abstract
The paper considers the problematics of identifying proper analogues for understanding carbonate and clastic reservoir distribution and prediction in the Lower Permian and Upper and Lower Carboniferous within the Dnieper-Donets basin.
The focus of the exploration team was finding meandering rivers. This choice was proven good in mapping reservoirs and finding traps deeper in the Upper and Middle Carboniferous, although for Permian clastic section the approach was not helpful. The second option was desert dunes, but poor sorting of reservoirs suggests a more complex picture. Analogues such as desert environment is quite logical for describing Lower Permian as aridic climate, with red and brown shales and sands.
Lower Permian reservoirs have a moon-like shape in the vertical sections that could be easily mistaken for river channels, but in such a dry climate, it is very likely water flow channels with sporadic hurricane-related activities. Core and logs shows chaotic grain sizes, but more with fine grains with almost no coarse grains. The source of sedimentary material could be mountains of Ukrainian Rock Shield from the South and Voronezh massif from the North.
This conceptual model is proposing not to look for meandering channels, but more for braided channels with poorly sorted material. The current time analogue could be the Oman desert between the mountains and peninsula. From satellite images, braided channels are clearly visible in the direction towards the Indian Ocean. The channels’ internal structure is quite heterogeneous.
This method suggests exploration targets with possible widths of the channels as big as hundreds of meters and their lengths under 10 and between 10-20 kilometres maximum.
NOC Subsurface Organization Transformation to Boost Its Resource Base and Secure Country's Energy Needs
Authors: Zharkeshov Sanzhar , Tleukhabyluly Olzhas , Loktiev Valentin , Atanayev Askar , Maccagni Agostino 
Published: November 2021

Abstract
UkrGasVydobuvannya (UGV) is an E&P organization of the National Oil Company (NOC) of Ukraine – Naftogaz Group. UGV's existing gas fields represent one of the largest reservoir portfolios in the Eastern Europe; however, the current depletion level of the company's fields is also among the highest; the bulk of the fields have depletion levels between 70 and 90%. The E&P Company (UGV) has created a resource base development strategy to plan and deliver exploration activities and reservoir management based on industry best practices to maintain and grow the company's production and bookable reserves for years to come.
The subsurface transformation program (including both exploration and reservoir management domains) addresses the actions taken to ensure success for the Strategy. Actions consider not only increase in exploration acreage or acquiring new fields and prospects, but also the organizational, cultural, technological and process level changes across the subsurface domain in the company. The program is still in the early implementation phase; however, the first material results are confirming the validity of the program:
Organization re-design per industry standards: asset development teams were established and aligned with the portfolio priorities; Digital database of subsurface data is being created and systemic reservoir surveillance is being executed; Growth source secured: Black Sea, new onshore unconventional and conventional licenses; Modern exploration practices, including risk-based probabilistic exploration drilling decisions and launching of Petroleum Systems Analysis and Basin modeling; Reshaping the obsolete rigid structure of the research institute into a modern R&D center; and, Professional development program tailored to build-up the modern skills and competencies of company's subsurface teams.
These and other important steps of the transformation will ultimately help the company to ensure a healthy reserves replacement ratio and increase the production share of greenfields in its portfolio.
This case study can serve as a blueprint for any medium-sized subsurface organization (especially in NOCs) that faces similar resource base challenges and wishes to improve its production performance.
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans
Authors: Wang Xiaoqun , Wang Wei , Wang Mengdi , Yang Meng , Zeng Bo , Qiu Wenying , Ma Qiang , Jing Xiaoxi , Zhang Qianqian , Wang Bosong , Yin Chonghai , Zhang Jiyao , Ge Yuxin , Lu Yufeng , Ji Weizhi , Wu Qian , Ma Chao 
Published: November 2021

Abstract
Whether adult hippocampal neurogenesis (AHN) persists in adult and aged humans remains extensive debates1-8. Here, to provide a better understanding of AHN of primates, droplet-based single nucleus RNA sequencing (snRNA-seq) is used to investigate the cellular heterogeneity and molecular characteristics of the hippocampi in macaques across the lifespan and in aged humans. We pinpoint the dynamics of the neurogenic lineage, including adult neural stem cells (NSCs) and immature neurons, and the diversity of astrocytes and microglia. In the neurogenic lineage, the regulatory continuum from adult NSCs to immature and mature granule cells is investigated. We identify ETNPPL as a primate-specific NSC marker and verify STMN1 and STMN2 as immature neuron markers in primates. Importantly, we also illustrate a cluster of active astrocytes and microglia exhibiting proinflammatory responses in aged samples. The interaction analysis implies that astrocytes are more important niche cells that provide signals inducing the proliferation, quiescence and inflammation of adult NSCs at different stages and thus are attributed to the decrease and variability of AHN in adult and elderly.
Non-steroidal anti-inflammatory drug use is determined by disease activity in axSpA and decreased by biologicals: a longitudinal analysis
Authors: Ediboglu Elif Durak , Solmaz Dilek , Kabadayı Gökhan , Gücenmez Sercan , Cinaklı Haluk , Akad Eda Otman , Özmen Mustafa , Akar Servet 
Published: November 2021

Abstract
Objective

To evaluate non-steroidal anti-inflammatory drug (NSAID) use and Assessment in Spondyloarthritis International Society (ASAS)-NSAID scores in patients with axial spondyloarhritis (axSpA) in a longitudinal study.
Methods

In total, 429 patients with axSpA (59% male; 63.6% with AS) were included in this study. Data about disease activity, C-reactive protein (CRP) levels, and NSAID use and dosage were collected at 0, 12, 24, and 52 weeks retrospectively. The relationship with NSAID use /NSAID scores and other factors was tested using generalized estimating equations (GEE).
Results

At baseline (0 weeks), 92.8% of patients started biologic disease-modifying anti-rheumatic drugs (bDMARDs) and 82.1% were conventionally treated with NSAIDs. At baseline, the proportion (p=0.03) and the median (IQR) ASAS-NSAID scores were higher in biologic treatment group [100 (50) vs 50 (83.4); p<0.001]. During follow-up, NSAID use and ASAS-NSAID scores decreased significantly in patients treated with bDMARDs (p<0.001) and the reduction remained stable throughout the follow-up However, neither NSAID use (p=0.06) nor ASAS-NSAID scores changed in conventionally treated patients (p=0.15). In bDMARD-treated patients, ASDAS-CRP and BASFI scores were independent determinants for NSAID use, and BASDAI and patient global assessment (PGA) were determinants for NSAID dosage. There was no independent significant predictor for ASAS-NSAID scores; PGA was the only significant predictor for NSAID use in the conventional treatment group.
Conclusion

Concurrent biologic treatment was associated with low NSAID intake in patients with axSpA, and NSAID use was determined mainly by disease activity and partly by function during bDMARD treatment.
C-Reactive Protein Levels do Not Correlate with Body Mass Index in Patients Hospitalized with Infectious Diseases: A Retrospective Study
Authors: chertok elena , Dori Guy , Schwartz Naama , Cheshin Ori , Nitzan Ronit , Ishay Avraham 
Published: November 2021

Abstract
Background.C-reactive protein (CRP) is an acute phase reactant protein synthesized in the liver. Human body proportions, such as body mass index (BMI), may affect CRP levels during infection. This study was carried out to investigate the relationship between CRP and BMI in obese versus non- obese patients hospitalized with common acute infections.MethodsA total of 445 patients admitted with diagnoses of pneumonia, urinary tract infections and cellulitis were included in the statistical analysis. Among them, 287 were diagnosed with pneumonia, 80 with UTIs and 78 with cellulitis. Each group was also divided according to their BMI. (< or ≥ 30 kg/m2). We gathered data for serial CRP measurements performed on day 0-1, 1-3, and 4-6 of hospitalization as well as BMI levels for all patients. Other markers of acute inflammation, including WBC, fibrinogen level, LDH, as well as albumin level and GFR were recorded.ResultsOverall, we found no difference in CRP levels in patients with or without obesity throughout the duration of their hospitalization. There was a trend of elevated CRP level at the beginning of hospitalization in the group with BMI≤30 (p=0.06). No correlation was found between CRP levels and BMI at the points of measurements during hospitalization in the three study groups.ConclusionCRP levels do not correlate with BMI and with other biomarkers of inflammation in patients hospitalized with acute infectious diseases.