bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutamatergic Medications for Obsessive-Compulsive and Related Disorders
Authors: Coelho David R. A. , Yang Chen , Suriaga Armiel , Manasa Justen , Bain Paul A. , Vieira Willians Fernando , Papatheodorou Stefania , Salvi Joshua D. 
Published: January 2025

ImportanceObsessive-compulsive and related disorders (OCRDs) encompass various neuropsychiatric conditions that cause significant distress and impair daily functioning. Although standard treatments are often effective, approximately 60% of patients may not respond adequately, underscoring the need for novel therapeutic approaches.ObjectiveTo evaluate improvement in OCRD symptoms associated with glutamatergic medications as monotherapy or as augmentation to selective serotonin reuptake inhibitors, with a focus on double-blind, placebo-controlled randomized clinical trials (RCTs).Data SourcesElectronic searches were conducted in PubMed, Embase, PsycINFO, Web of Science, and Cochrane Central Register of Controlled Trials on October 16, 2024, without date limits.Study SelectionTwo investigators independently screened records to identify double-blind RCTs comparing glutamatergic medications with placebo for patients with OCRDs regardless of age, sex, gender, or refractoriness. Abstracts, study protocols, non-English studies, and trials involving augmentation to psychotherapy were excluded.Data Extraction and SynthesisData were extracted and synthesized using random-effects meta-analyses. Subgroup analysis was conducted based on type of OCRD, population, refractoriness of OCRD, augmentation strategy, risk of bias, and type of glutamatergic medication. Sensitivity analysis was performed using a leave-one-out approach.Main Outcomes and MeasuresImprovement in OCRD symptoms was measured by standardized mean difference (Cohen d). Improvement in obsessive-compulsive disorder (OCD) symptoms was measured by mean difference (reduction in Yale-Brown Obsessive Compulsive Scale [Y-BOCS] scores).ResultsA total of 27 RCTs (1369 participants; mean [SD] age, 31.5 [7.8] years; 65.6% female) were included. Glutamatergic medications showed a large effect size in improving OCRD symptoms (Cohen d = −0.80 [95% CI, −1.13 to −0.47]; low certainty of evidence). In the 23 OCD-specific RCTs, glutamatergic medications demonstrated a significant mean reduction in Y-BOCS scores (mean difference, −4.17 [95% CI, −5.82 to −2.52]; moderate certainty of evidence).Conclusions and RelevanceThese findings indicate that glutamatergic medications may be effective in treating OCRDs, particularly OCD. However, high heterogeneity and potential publication bias necessitate cautious interpretation. Further research with larger sample sizes is needed to explore dose-dependent effects, additional OCRD subtypes, and other promising glutamatergic medications.
Requests for Medical Assistance in Dying by Young Dutch People With Psychiatric Disorders
Authors: Schweren Lizanne J.S. , Rasing Sanne P.A. , Kammeraat Monique , Middelkoop Leah A. , Werner Ruthie , Mérelle Saskia Y.M. , Garcia Julian M. , Creemers Daan H.M. , van Veen Sisco M.P. 
Published: January 2025

ImportanceIn the Netherlands, a growing group of young people request medical assistance in dying based on psychiatric suffering (MAID-PS). Little is known about this group, their characteristics, and outcomes.ObjectiveTo assess the proportion of requests for and deaths by MAID-PS among young patients, outcomes of their application and assessment procedures, and characteristics of those patients who died by either MAID or suicide.Design, Setting, and ParticipantsThis retrospective cohort study included Dutch individuals younger than 24 years requesting MAID-PS between January 1, 2012, and June 30, 2021, whose patient file had been closed by December 1, 2022, at the Expertisecentrum Euthanasie, a specialized health care facility providing MAID consultation and care.Main Outcomes and MeasuresOutcomes of the MAID-PS assessment procedure (discontinued, rejected, or MAID-PS) and clinical characteristics of patients who died by MAID or suicide.ResultsThe study included 397 processed applications submitted by 353 individuals (73.4% female; mean [SD] age, 20.84 [1.90] years). Between 2012 and the first half of 2021, the number of MAID-PS applications by young patients increased from 10 to 39. The most likely outcome was application retracted by the patient (188 [47.3%]) followed by application rejected (178 [44.8%]). For 12 applications (3.0%), patients died by MAID. Seventeen applications (4.3%) were stopped because the patient died by suicide during the application process and 2 (0.5%) because the patient died after they voluntarily stopped eating and drinking. All patients who died by suicide or MAID (n = 29) had multiple psychiatric diagnoses (most frequently major depression, autism spectrum disorder, personality disorders, eating disorder, and/or trauma-related disorder) and extensive treatment histories. Twenty-eight of these patients (96.5%) had a history of suicidality that included multiple suicide attempts prior to the MAID application. Among 17 patients who died by suicide, 13 of 14 (92.9%) had a history of crisis-related hospital admission, and 9 of 12 patients who died by MAID (75.0%) had a history of self-harm.Conclusions and RelevanceThis cohort study found that the number of young psychiatric patients in the Netherlands who requested MAID-PS increased between 2012 and 2021 and that applications were retracted or rejected for most. Those who died by MAID or suicide were mostly female and had long treatment histories and prominent suicidality. These findings suggest that there is an urgent need for more knowledge about persistent death wishes and effective suicide prevention strategies for this high-risk group.
Psoriasis and dementia: A population‐based matched cohort study of adults in England
Authors: Matthewman Julian , Mansfield Kathryn E. , Cadogan Sharon L. , Abuabara Katrina , Smith Catherine , Bhaskaran Krishnan , Langan Sinéad M. , Warren‐Gash Charlotte 
Published: January 2025

AbstractObjectiveEvidence for an association between psoriasis and dementia is limited and conflicting. We aimed to investigate the association using large and representative population‐based data and describe risk by dementia subtype and over time.MethodsWe compared dementia risk between people with and without psoriasis using an age‐, sex‐ and primary care practice‐matched cohort of adults aged ≥40 years from the Clinical Practice Research Datalink Aurum in England (1997–2021) linked to hospital admissions data, analysed with stratified Cox regression.ResultsAmong 360,014 individuals with psoriasis and 1,799,617 without, psoriasis was associated with a small increased risk of all‐cause dementia (adjusted hazard ratio [aHR] 1.06, 95% CI 1.04–1.08; absolute rate difference 24 per 100,000 person‐years). Strength of association increased with time since psoriasis diagnosis (e.g. aHR 0.99, 0.96–1.03 within 0 to 5 years; 1.20, 1.05–1.37 within 20 to 25 years). The association was stronger for vascular dementia (aHR 1.10, 1.06–1.14) than Alzheimer's dementia (aHR 1.03, 1.00–1.06). Hazard ratios were larger for severe psoriasis (all‐cause aHR 1.32, 1.25–1.39; vascular aHR 1.58, 1.44–1.74; Alzheimer's aHR 1.11, 1.02–1.21).InterpretationLong‐term risk of all‐cause dementia and vascular dementia, but not Alzheimer's dementia, was slightly higher in people with psoriasis, but absolute risk differences were small. Risks were more substantially raised with time since psoriasis diagnosis and in severe psoriasis compared to mild to moderate psoriasis, suggesting a potential dose–response relationship.
Unlocking Zero Liquid Discharge: A Parallel Water Supply Strategy to Realize Selective Salt Crystallization for Long‐Term Interfacial Solar Evaporation
Authors: Xiong Qianqian , Wang Deyu , Shao Bo , Yu Huimin , Wu Xuan , Lu Yi , Yang Xiaofei , Xu Haolan 
Published: January 2025

AbstractInterfacial solar evaporation offers a green and sustainable solution to solve clean water shortages via solar‐driven desalination. However, salt crystallization and accumulation on solar evaporators have become the primary hindrances to the long‐term practical application of interfacial solar evaporation technology. To tackle this challenge, a photothermal evaporator with a novel parallel two‐water paths strategy is developed in this study. Unlike the conventional one‐way water path, which generally leads to salt accumulation at the water supply end on the evaporation surfaces, thereby limiting the lifespan of the evaporator and compromising solar evaporation performance, here, with the second parallel water supply path, the ion diffusion and distribution within the solar evaporator is reconfigured and optimized. No salt accumulation occurs on either the evaporation surfaces or the water paths, eliminating the impact of salt crystallization on evaporation performance and enabling convenient salt collection. A high and stable evaporation rate of 3.09–3.26 kg m−2 h−1 is recorded over 84 h continuous evaporation of NaCl solution (3.5 wt.%) without salt accumulation on the evaporator, making it an ideal strategy for zero liquid discharge solar evaporation.
One‐Step, Mask‐Free, Rapid Laser Writing Fabrication of Electroluminescent Perovskite@Oxide Pixels for Ultra‐High PPI, Efficient Micro‐QLEDs
Authors: Ma Teng , Wang Yifei , Chen Jun , Wang Run , Lv Rongqiu , Chen Ziyi , Guo Weishu , Guo Tingting , Ji Yucong , Song Xiufeng , Fan Zhiyong , Xiang Hengyang , Li Zhenhua , Zeng Haibo 
Published: January 2025

AbstractWide color gamut and high resolution are becoming key features of the new generation of displays, and hence quantum dots pixels with high luminescence purity have been placed great expectations. However, how to facilely and rapidly fabricate electroluminescent pixels with both high pixels per inch (PPI) and high quantum efficiency has been a great challenge. Here, a one‐step, mask‐free, rapid laser writing strategy to fabricate ultra‐high resolution perovskite quantum dots (PQDs) pixels is presented. It is found that the laser‐induced reaction can convert PQDs into oxide, forming perovskite@oxide pixel arrays, replacing the complex etching and deposition processes previously used. Benefiting from the formation of the oxide layer, electrons transport can be effectively blocked in the non‐emitting region, thus reducing the charge leakage in micro quantum dots light emitting diodes (Micro‐QLED) arrays. Finally, red, green, blue Micro‐QLEDs are achieved with PPIs ranging from 2000 to 5000 and the highest external quantum efficiency of 17.24%, 21%, and 6.6% respectively. These results are record‐breaking in perovskite Micro‐QLEDs, providing the strategy for active‐matrix electroluminescent high‐resolution pixel arrays for next‐generation monochromatic displays.
Antagonistic Two‐Color Control of Polymer Network Formation
Authors: Marco Arnau , Villabona Marc , Eren Tugce Nur , Feist Florian , Guirado Gonzalo , Sebastián Rosa M. , Hernando Jordi , Barner‐Kowollik Christopher 
Published: January 2025

AbstractOffering high spatiotemporal resolution, dual wavelength‐controlled soft matter network formation paves the way to advanced printing techniques with optimized performance. One of the most promising approaches is the antagonistic control of covalent bond‐forming reactions with two colors of light, where photoexcitation with one wavelength induces a photochemical reaction, while irradiation with the other ceases it in the presence of the first color. Herein, we combine a photoactivatable diene precursor and a photoswitchable dienophile, establishing a dual‐wavelength‐gated cycloaddition reaction capable of controlling polymer crosslinking. Upon incorporation of the diene precursor into a methacrylate copolymer and the synthesis of a difunctional dienophile cross‐linker, selective polymer network formation is promoted under sole UV illumination, while it can be efficiently suppressed with simultaneous redlight irradiation. Critically, the methodology is used for the preparation of solid polymer materials with antagonistic two‐color control of their cross‐linking status, ultimately allowing the fabrication of spatially patterned polymer films.
Microenvironment‐Regulated Dual‐Layer Microneedle Patch for Promoting Periodontal Soft and Hard Tissue Regeneration in Diabetic Periodontitis
Authors: Qu Yaning , Zeng Huajing , Wang Lei , Ge Zhenlin , Liu Bin , Fan Zengjie 
Published: January 2025

AbstractChronic periodontitis in individuals with diabetes can exacerbate the destruction of local periodontal soft tissues and accelerate the resorption of hard tissue. Currently, effective strategies to simultaneously restore both soft and hard periodontal tissues remain insufficient. To address this challenge, a multifunctional dual‐layer microneedles (d‐MNs) design is proposed to regenerate both periodontal soft and hard tissues in diabetic patients. The d‐MNs substrate is composed of gelatin methacryloyl (GelMA) infused with nano‐hydroxyapatite (nHA), which facilitates the differentiation of osteogenic cells into osteoblasts, thereby promoting alveolar bone regeneration. The tips of the d‐MNs, on the other hand, are primarily made of hyaluronic acid (HA) combined with a magnesium‐based metal‐organic framework (Mg‐MOF) loaded with glucose oxidase (GOX). This composition creates a hypoglycemic, angiogenic, and anti‐inflammatory microenvironment, which supports soft tissue repair. When implanted at the site of periodontitis, the synergistic interaction between the d‐MNs substrate and tips effectively promotes the regeneration of both soft and hard tissues, as demonstrated in diabetic rat models of periodontitis. These innovative d‐MNs have the potential to revolutionize traditional approaches to treating diabetic periodontitis and can see broad application in dental clinics.
Halogenated Ethylamine Hydrochloride Modulation Facilitating a VOC of 1.19 V in Perovskite Solar Cells
Authors: Wang Ying , Wu Jihuai , Deng Chunyan , Liu Fengli , Guo Mengyao , Xu Jingwei , Gao Lin , Huang Miaoliang , Lan Zhang , Gao Peng 
Published: January 2025

AbstractInterface engineering has emerged as an effective strategy for optimizing the charge carrier dynamics in perovskite solar cells, and the design of modulators plays a crucial role in improving interface effects. Here, halogenated ethylamine hydrochloride (XEA), such as 2‐fluoroethylamine hydrochloride (FEA), 2‐chloroethylamine hydrochloride (CEA), or ethylamine hydrochloride (EA), is incorporated into the buried interface between perovskite layer (PVK) and SnO2 electron transport layer (ETL) to assist crystal growth, tune the energy level and passivate defects. Pre‐embedded XEA interacts with PbI2 to form a 2D mesophase. The mesophase assists the growth dynamics and orientation of the epitaxial perovskite, resulting in uniform perovskite films with larger grains and higher densification, effectively reducing the defects caused by excess PbI2 at the buried interface. NH3+ cation and X− anion ions on XEA fill and coordinate the vacancies, passivating the defects in SnO2 and perovskite. Meanwhile, the introduction of XEA adjusts the energy match between PVK/ETL, compensating the energy loss at the buried interface. Consequently, the FEA‐modified devices exhibited a power conversion efficiency of 24.7%, featuring an exceptionally high open‐circuit voltage of 1.19 V and remarkable stability.
A Flexible Impact Sensor of Interpenetrating‐Phase Composite Architecture with High Mechanical Stability and Energy‐Absorbing Capability
Authors: Guo Shu , Qi Jiawei , Wang Yixiao , Liu Zhanli , Li Jing 
Published: January 2025

AbstractFlexible electromechanical sensors frequently suffer from unexpected impact loadings caused by slipping, collisions and falling objects, to name a few. Without sufficient protection, these undesired impacts would lead to critical mechanical instability even damage to flexible sensors, resulting in restricted measurement range and imprecise sensing. Thus, it is of significance, but still is a fresh challenge to enhance the mechanical stability and energy‐absorption capacity of flexible sensors under impacts. Here, a multi‐design strategy is proposed to construct an interpenetrating‐phase cellulose‐acetate composite (IPC2) architecture for flexible sensors in impact‐intensive sensing applications. The external structure mimics bellows‐morphology of beverage‐straws that deform in programmed loading direction to enhance the mechanical stability, while the internal conductive core has a co‐continuous interpenetrating‐phase architecture that can efficiently absorb impact energy. Systematic numerical analysis and experimental tests demonstrate that IPC2 architecture presents excellent structural stability, cyclic performance and a unique combination of exceptional specific energy absorption (SEA = 2.66±1.2 kJ kg−1), low density (ρ = 720±10 kg m−3), electromechanical properties (GF≈39.6). Remarkably, the recovery behaviors in terms of shape and electrical signals show good repeatability and reliability. This study offers a new composite framework to exploit the potentialities of flexible sensors with protective functions and commercial values.
An Urchin‐Inspired Broadband and Ultralight Microwave Absorber
Authors: Zhang You , Gong Xiaofeng , Zeng Yanan , Dong Xingjun , Guo Hui , Jiang Zhenhua , Hu Tianjiao , Wang Jing , Zou Yanhong , Chu Zengyong 
Published: January 2025

AbstractThe incompatibility between low and high frequencies, and the constraints of thickness and absorption bandwidth, are great challenges for electromagnetic wave (EMW) absorbers. The combination of microscopic wrinkled morphology and macroscopic stacking structure offers the possibility of constructing lightweight and broadband EMW‐absorbing materials. Herein an artificial periodic unit is demonstrated, wCNT@PS/R, which consists of the urchin‐inspired wrinkled‐carbon nanotube (CNT)‐coated polystyrene (PS) spheres and the organosilicon rubber matrix. The unit thickness and the unit geometry are studied and optimized. Due to the good impedance matching, excellent macrostructural reflections, and strong dielectric loss, the pentagon unit achieves a promising effect absorption band (EAB) of 12.61 GHz, covering both the low‐frequency (S‐ and C‐band) and the high‐frequency (X‐ and Ku‐band) bands. The thickness is 4.0 mm and the total density is as low as 0.194 g cm−3, which provides a new idea for the cost‐effective preparation of thin, ultralight, and broadband EMW absorbers.
Type‐Transformational BioHJzyme Enabled by Composition Modulation‐Mediated Energy Band Engineering for Diabetic Infectious Wound Healing
Authors: He Miaomiao , Wang Zuyao , Sun Dan , Deng Yi , Yang Weizhong , Yin Guangfu 
Published: January 2025

AbstractThe dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating the hyperglycemia. The pivotal anti‐pathogenic efficiency is focused on the confined and gradually weaken reactive oxygen species (ROS) yield in the peculiar micromilieu owing to the materials transformation/dissolution. There, the type‐transformational bio‐heterojunction enzyme (BioHJzyme) with operando composition‐modulation is proposed, which is consisted by glucose oxidase (GOx) decorated type‐I FeSe2/Cu2O heterojunction. It exhibits robust catalytic efficiency to produce ROS. Followed, the type‐I heterojunction can be transformed into dual Z‐scheme heterojunction with a composition of FeSe2/CuSe/Cu2O primed by the infectious acid micromilieu with a meliorative energy band. It is conducive to the NIR‐induced capabilities to improve ROS yield. The GOx can consume glucose to produce H2O2 as an amplifier. The combined catalytic efficiency of type‐I heterojunction and the followed enhanced NIR‐induced capabilities of dual Z‐scheme heterojunction can powerfully remove the pathogenic colonization. On top of that, the sample can downgrade the Forkhead box O (FoxO) signaling pathway to regulate cell cycle, facilitate cell proliferation, and further promote wound repairment. This work provides an effective and feasible antibacterial strategy and way of thinking for the diabetic infectious wound healing.
Prognosis of Cardiovascular Conditions Noninvasively Using Printable Elastomeric Electronic Skin
Authors: Selvan T Muthamil , Mondal Titash 
Published: January 2025

AbstractLack of timely prognosis of cardiovascular condition (CVC) is resulting in increased mortality across the globe. Currently, available techniques are confined to medical facilities and need the intervention of specialists. Frequently, this impedes timely treatment, driven by socioeconomic factors. Consequently, the disease transcends toward incurable complications. In such a scenario, point‐of‐care diagnostic tools can help with prognosis at an early stage. Albeit there are such tools available, it is imperative to develop affordably in uncomplicated manufacturing techniques and should have simple readout and analysis modules for monitoring CVC. Accordingly, the solvent‐free manufacturing of stencil printable liquid elastomer‐carbon nanotube electronic skin‐based strain sensor, capable of accurately detecting pulse (at different positions) and other parameters like augmentation index and stiffness index of artery related to the CVC, is reported. The Poincare plot, derived from the recorded data, measures heart rate variability, a key indicator linked to mortality. Thanks to the staggering linearity, gauge factor of 234.26, fast response time of 85 ms (measured from pulse data), and cyclic stability (over 500 cycles), assist in the ease of detection of vital parameters. Furthermore, the sensor patch demonstrates its capability to acquire pulse waves under different real‐time artery conditions using cuff‐based pressure applications.
Permanent Electride Magnets Induced by Quasi‐Atomic Non‐Nucleus‐Bound Electrons
Authors: Hwang Jeong Yun , Lee Seung Yong , Lee Kimoon , Regmi Binod , Lee Nahyun , Lim Dong Cheol , Koo Heejeong , Lee Wooyoung , Kim Seong‐Gon , Kim Sung Wng , Lee Kyu Hyoung 
Published: January 2025

AbstractInterstitial quasi‐atomic electrons (IQEs) in the quantized energy levels of positively charged cavities possess a substantial own magnetic moment and control the magnetism of crystalline electrides depending on the interaction with surrounding cations. However, weak spin‐orbit coupling and gentle exchange interaction restricted by the IQEs preclude a large magnetic anisotropic, remaining a challenge for a hard magnetism. It is reported that 2D [Re2C]2+·2e− electrides (Re = Er, Ho, Dy, and Tb) show the permanent magnetism in a ferrimagnetic ground state, mimicking the ferrites composed of magnetic sublattices with different spin polarizations. Magnetic interaction between Re‐spin lattice and IQE‐spin lattice in the [Re2C]2+·2e− electrides results in a large magnetocrystalline anisotropy and high coercivity, giving a maximum energy product of 15 MGOe. It is demonstrated that the spontaneous breaking of magnetic IQE‐sublattice through substitution with paramagnetic elements produces a crossover into an antiferromagnetic spin ordering of Re‐sublattice, implying that the magnetic sublattice of IQEs drives the permanent magnetism.