bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome
Authors: Zhao Yan , Wang Qibin , Yan Shan , Zhou Jun , Huang Liangyong , Zhu Haitao , Ye Fang , Zhang Yonghong , Chen Lin , Chen Li , Zheng Tao 
Published: April 2021

The aim of this study was to evaluate the therapeutic effects of Bletilla striata polysaccharide (BSP) on wound healing in diabetes mellitus (DM) and to explore the underlying mechanisms. DM mouse models were induced by high fat-diet feeding combined with low-dose streptozocin injection. To establish diabetic foot ulcer (DFU) models, DM mice were wounded on the dorsal surface. Subsequently, mice were treated with vehicle or BSP for 12 days and wound healing was monitored. The effects of BSP on the production of interleukin-1β (IL-1β), tumor necrosis factor-α, macrophages infiltration, angiogenesis, the activation of nucleotide-binding and oligomerization (NACHT) domain, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome, and insulin sensitivity in wound tissues were subsequently evaluated. Separated- and cultured- bone marrow-derived macrophages (BMDMs) and cardiac microvascular endothelial cells (CMECs) were isolated from mice and used to investigate the effects of BSP on cell viability, reactive oxygen species (ROS) generation, NLRP3 inflammasome activation and insulin sensitivity in vitro following exposure to high glucose (HG). BSP administration accelerated diabetic wound healing, suppressed macrophage infiltration, promoted angiogenesis, suppressed NLRP3 inflammasome activation, decreased IL-1β secretion, and improved insulin sensitivity in wound tissues in DM mice. In vitro, co-treatment with BSP protected against HG-induced ROS generation, NLRP3 inflammasome activation, and IL-1β secretion in BMDMs, and improved cell viability and decreased ROS levels in CMECs. Moreover, in HG exposed BMDMs-CMECs cultures, BSP treatment suppressed NLRP3 inflammasome activation and IL-1β secretion in BMDMs, and improved cell viability and insulin sensitivity in CMECs. Furthermore, treatment with IL-1β almost completely suppressed the beneficial effects of BSP on the NLRP3 inflammasome, IL-1β secretion, and insulin sensitivity in HG-treated BMDMs-CMECs. BSP promotes DFU healing through inhibition of the HG-activated NLRP3 inflammasome.
Breaching the Delivery Barrier: Chemical and Physical Airway Epithelium Disruption Strategies for Enhancing Lentiviral-Mediated Gene Therapy
Authors: McCarron Alexandra , Farrow Nigel , Cmielewski Patricia , Knight Emma , Donnelley Martin , Parsons David 
Published: April 2021

The lungs have evolved complex physical, biological and immunological defences to prevent foreign material from entering the airway epithelial cells. These mechanisms can also affect both viral and non-viral gene transfer agents, and significantly diminish the effectiveness of airway gene-addition therapies. One strategy to overcome the physical barrier properties of the airway is to transiently disturb the integrity of the epithelium prior to delivery of the gene transfer vector. In this study, chemical (lysophosphatidylcholine, LPC) and physical epithelium disruption using wire abrasion were compared for their ability to improve airway-based lentiviral (LV) vector mediated transduction and reporter gene expression in rats. When luciferase expression was assessed at 1-week post LV delivery, LPC airway conditioning significantly enhanced gene expression levels in rat lungs, while a long-term assessment in a separate cohort of rats at 12 months revealed that LPC conditioning did not improve gene expression longevity. In rats receiving physical perturbation to the trachea prior to gene delivery, significantly higher LacZ gene expression levels were found when compared to LPC-conditioned or LV-only control rats when evaluated 1-week post gene transfer. This proof-of-principle study has shown that airway epithelial disruption strategies based on physical perturbation substantially enhanced LV-mediated airway gene transfer in the trachea.
Improving Care for Deinstitutionalized People With Mental Disorders: Experiences of the Use of Knowledge Translation Tools
Authors: Fulone Izabela , Barreto Jorge Otavio Maia , Barberato-Filho Silvio , Bergamaschi Cristiane de Cássia , Silva Marcus Tolentino , Lopes Luciane Cruz 
Published: April 2021

Background: The deinstitutionalization process is complex, long-term and many countries fail to achieve progress and consolidation. Informing decision-makers about appropriate strategies and changes in mental health policies can be a key factor for it. This study aimed to develop an evidence brief to summarize the best available evidence to improve care for deinstitutionalized patients with severe mental disorders in the community.Methods: We used the SUPPORT (Supporting Policy Relevant Reviews and Trials) tools to elaborate the evidence brief and to organize a policy dialogue with 24 stakeholders. A systematic search was performed in 10 electronic databases and the methodological quality of systematic reviews (SRs) was assessed by AMSTAR 2.Results: Fifteen SRs were included (comprising 378 studies and 69,736 participants), of varying methodological quality (3 high-quality SRs, 2 moderate-quality SRs, 7 low-quality SRs, 3 critically low SRs). Six strategies were identified: (i). Psychoeducation; (ii). Anti-stigma programs, (iii). Intensive case management; (iv). Community mental health teams; (v). Assisted living; and (vi). Interventions for acute psychiatric episodes. They were associated with improvements on a global status, satisfaction with the service, reduction on relapse, and hospitalization. Challenges to implementation of any of them included: stigma, the shortage of specialized human resources, limited political and budgetary support.Conclusions: These strategies could guide future actions and policymaking to improve mental health outcomes.
Problematic Use of the Internet in Subjects With Bipolar Disorder: Relationship With Posttraumatic Stress Symptoms
Authors: Carmassi Claudia , Bertelloni Carlo Antonio , Cordone Annalisa , Dell'Oste Valerio , Pedrinelli Virginia , Barberi Filippo Maria , Massimetti Enrico , Bui Eric , Dell'Osso Lliliana 
Published: April 2021

Background: Literature shows a high risk for problematic use of the Internet (PUI) in mood disorders, especially in bipolar disorder (BD). In subjects with BD, traumatic events and posttraumatic stress disorder (PTSD) are related to alcohol or substance use disorder, as well as to gambling disorder. However, little is known about the possible association between traumatic exposure and PUI. The present study was aimed at examining the relationship between PUI and trauma exposure, besides PTSD symptoms, in subjects with BD.Methods: A sample of 113 subjects with BD was screened to putative PUI. Furthermore, they completed the Trauma and Loss Spectrum Self-Report (TALS-SR) to assess traumatic events and posttraumatic stress symptoms.Results: Twenty-four subjects (21.2%) reported putative PUI. Subjects with putative PUI presented significantly higher scores in the TALS-SR domains Potentially Traumatic Events, Re-experiencing, Maladaptive coping, and Arousal, as well as in the TALS-SR total score. In a logistic regression model, a positive association emerged between Potentially Traumatic Events and Arousal TALS-SR domains and putative PUI.Conclusion: One in five patients with BD screened positive for PUI. A significant association between PUI and lifetime traumatic events as well as PTSD symptoms emerged, highlighting the relevance of the comorbidity between PTSD and PUI in subjects with BD.
The Effect of Footwear, Running Speed, and Location on the Validity of Two Commercially Available Inertial Measurement Units During Running
Authors: Napier Christopher , Willy Richard W. , Hannigan Brett C. , McCann Ryan , Menon Carlo 
Published: April 2021

Introduction: Most running-related injuries are believed to be caused by abrupt changes in training load, compounded by biomechanical movement patterns. Wearable technology has made it possible for runners to quantify biomechanical loads (e.g., peak positive acceleration; PPA) using commercially available inertial measurement units (IMUs). However, few devices have established criterion validity. The aim of this study was to assess the validity of two commercially available IMUs during running. Secondary aims were to determine the effect of footwear, running speed, and IMU location on PPA.Materials and Methods: Healthy runners underwent a biomechanical running analysis on an instrumented treadmill. Participants ran at their preferred speed in three footwear conditions (neutral, minimalist, and maximalist), and at three speeds (preferred, +10%, −10%) in the neutral running shoes. Four IMUs were affixed at the distal tibia (IMeasureU-Tibia), shoelaces (RunScribe and IMeasureU-Shoe), and insole (Plantiga) of the right shoe. Pearson correlations were calculated for average vertical loading rate (AVLR) and PPA at each IMU location.Results: The AVLR had a high positive association with PPA (IMeasureU-Tibia) in the neutral and maximalist (r = 0.70–0.72; p ≤ 0.001) shoes and in all running speed conditions (r = 0.71–0.83; p ≤ 0.001), but low positive association in the minimalist (r = 0.47; p &lt; 0.05) footwear condition. Conversely, the relationship between AVLR and PPA (Plantiga) was high in the minimalist (r = 0.75; p ≤ 0.001) condition and moderate in the neutral (r = 0.50; p &lt; 0.05) and maximalist (r = 0.57; p &lt; 0.01) footwear. The RunScribe metrics demonstrated low to moderate positive associations (r = 0.40–0.62; p &lt; 0.05) with AVLR across most footwear and speed conditions.Discussion: Our findings indicate that the commercially available Plantiga IMU is comparable to a tibia-mounted IMU when acting as a surrogate for AVLR. However, these results vary between different levels of footwear and running speeds. The shoe-mounted RunScribe IMU exhibited slightly lower positive associations with AVLR. In general, the relationship with AVLR improved for the RunScribe sensor at slower speeds and improved for the Plantiga and tibia-mounted IMeasureU sensors at faster speeds.
Horizontes temporales para pensar la emancipación. Leer en clave feminista y desde el sur
Authors: Ciriza Alejandra 
Published: April 2021

El trabajo apuesta a complejizar la construcción de genealogías feministas desde el sur a partir de una reflexión que parte del supuesto de que, por decirlo a la manera de Benjamin, una secreta clave liga las tentativas emancipatorias del pasado y las del presente.
La relación entre pasado y presente es un territorio de combate en el cual se han construido tradiciones selectivas que buscan expulsar a los/las sujetos subalternizados. Debido a su significado histórico y político uno de los momentos privilegiados, una suerte de puerta de entrada a esta reflexión, es el ciclo de revueltas y revoluciones que culminó con la ruptura del lazo colonial clásico.
Las historias patrias han borrado a las mujeres transgresoras e insumisas, a las racializadas e incluso a las ilustradas, pues sus relatos están cruzados por los obstáculos del androcentrismo y la mirada clasista, del racismo y el eurocentrismo.
Este trabajo busca no solo reflexionar sobre los sentidos de la emancipación, sino recuperar las complejidades y tensiones de nuestras genealogías como feministas del sur a partir de la revisión de documentos históricos de la independencia hispanoamericana y de las historias patrias, así como también a partir de una reflexión teórica sobre las nociones de emancipación, temporalidad, feminismo(s).
El pasado inconcluso y preñado de promesas de las revoluciones se erige como testigo de nuestras efímeras victorias y nuestras derrotas y se contrapone, a la manera de interrupción y advertencia, al pasado continuo de la clase dominante que se conjuga en masculino, blanco y burgués.
Cultura, sexualidad y censura estatal en el cine de Argentina y Brasil entre los años 1960 y 1980
Authors: D'Antonio Débora , Eidelman Ariel 
Published: April 2021

Este artículo propone un análisis de las principales características de la producción cinematográfica de carácter erótico en la industria cultural de Argentina y Brasil a partir de los años 60 y durante las dos décadas siguientes. Se trata de un tipo de cine que tuvo lugar en el marco de dictaduras de seguridad nacional de marcado carácter conservador y que además representó una porción significativa de la producción local e importantes éxitos de público. Apuntamos a examinar algunas producciones fílmicas marcadas por un fuerte erotismo como las pornochanchadas brasileras y las sexycomedias con vedettes y capos cómicos argentinas. Proponemos establecer ejes transversales para examinar las formas específicas que asumieron las políticas sexuales en relación a la cultura audiovisual bajo los Estados de seguridad nacional de Brasil y Argentina, aportando a la comprensión de aspectos menos conocidos del control estatal, y a su cruce con los discursos familiaristas y tradicionalistas de estos regímenes militares.
Estos regímenes militares ejercieron un control férreo y permanente sobre las producciones intelectuales, culturales y artísticas. Pero en el ámbito de la cinematografía, si bien se practicó la censura por medio de cortes de escenas y, en algunos casos, de prohibiciones plenas de las obras; a la vez desde el Estado se contribuyó con el financiamiento de algunos de este tipo de proyectos y se favoreció su desarrollo con cuotas de producción y/o exhibición en el mercado local. En tal sentido, no solo se toleró, sino que se estimuló la presencia de películas de carácter erótico en el mercado cinematográfico para estimular formas de divertimento controladas ante las fuertes restricciones a la libertad.
Evaluation of political actors (Satirical Shows)
Authors: Nitsch Cordula , Lichtenstein Dennis 
Published: April 2021

The variable “evaluation of political actors” examines which criteria are addressed in satirical shows to evaluate political actors. Evaluations can be based on role-specific criteria of political actors or on jokes that are related to politically irrelevant aspects such as personal traits, self-deprecation, and stereotypes (Emde & Scherer, 2016; Lichtenstein & Nitsch, 2018). The variable is an indicator for a show’s humor conventions as well as for the way the show deals with political content. The unit of analysis is the joke, which targets a political actor.

Field of application/theoretical foundation:
This variable is used to analyze the extent of substantial political information in satirical shows. It is also used to compare different types of satirical shows (e.g., Late Night Comedy news satire) or to assess the depiction of different political actors and whether or not they are embedded into different types of jokes.

References/combination with other methods of data collection
–

Example study:
Lichtenstein & Nitsch (2018)

Information on Lichtenstein & Nitsch, 2018
Authors: Dennis Lichtenstein, Cordula Nitsch
Research question/research interest: Depiction of politics in satirical shows
Object of analysis: Three popular German satirical TV-shows (Die Anstalt, heute show, Neo Magazin Royale)
Timeframe of analysis: 2014-2016

Information about variable
Variable name/definition: Criticism

V29 KRITIK
Kritik am Akteur
Hier wird codiert, auf welche Weise der Akteur in dem angesprochenen Themenkontext bewertet wird. Es wird festgehalten, ob die Bewertung positiv oder negativ ausfällt und ob sie sich auf Sachaspekte oder Persönlichkeitsmerkmale bezieht.

It is coded, in which way the actor is evaluated in the addressed topic context. It is coded whether the evaluation is positive or negative and whether it refers to role specific criteria or personality traits.

Nur Personen-aspekte

V.a. Personen-aspekte

Gleichermaßen Sach- und Personen-aspekte

V.a. Sachaspekte

Nur Sachaspekte

Weder Sach- noch Personen-aspekte

1x

2x

3x

4x

5x

9x

Nur positive Bewertung

x1

V.a. positive Bewertung

x2

Ambivalent

x3

V.a. negativ Bewertung

x4

Nur negative Bewertung

x5

Keine Bewertung

x0

References
Lichtenstein, D. & Nitsch, C. (2018). Informativ und kritisch? Die Politikdarstellung in deutschen Satiresendungen. [Informative and critical? The presentation of politics in German satirical programmes.] Medien und Kommunikationswissenschaft, 66(1), 5-21.
Different IOP, different diseases?
Authors: Iester Michele , D’Alessandro Elisa 
Published: April 2021

Glaucoma is a chronic, progressive disease characterized by typical optic nerve head changes and visual field defects. These alterations are caused by an intraocular pressure (IOP) being too high for the wellbeing of the specific optic disc. Typical clinical findings in glaucoma patients include thinning of the optic disc rim (Fig. 1), loss of retinal nerve fibers in the inferior sector with subsequent visual field defects in the superior sector.
A model for tear film dynamics during a realistic blink
Authors: Maki Kara Lee , Henshaw William , McManus Alex , Braun Richard , Chapp Dylan , Driscoll Tobin 
Published: April 2021

Each time one blinks, a stable tear film (TF) must reestablish itself on the ocular surface to ensure the function and health of the eye. Although the formation of the TF has been extensively studied both experimentally and theoretically, the influence of the lid dynamics on the TF formation is still not fully understood. Experimental instrumentation does not yet have the capability to estimate the TF thickness in vivo over the entire front of the eye, especially near the lids during a blink, where the eyelashes obstruct the view of the ocular surface. Additionally, a realistic blinking eyeshaped domain presents challenges in approximating themotion of the TF in theoretical studies. In thiswork,we overcome these theoretical challenges by implementing a moving overset grid method to study the influence of the lid motion on the formation of TF.
PAMSWAKARSA DALAM KONFLIK AGRARIA DI LAMPUNG: ANTARA KEPENTINGAN PERUSAHAAN, NEGARA, DAN MASYARAKAT
Authors: Karisma Gita 
Published: April 2021

This research aims to explore pamswakarsa which was created by corporation and its position on on agrarian conflict in Lampung Province, Indonesia. By using qualitative approach through the methods of interviews and utilizing several related documents, this research finds that pamswakarsa is assumed as paramilitary. Pamswakarsa itself emerged while conflict is existing. It is not relavant enough to support the effort in achieving order and peaceful, as was legally mandated by the regulation from The Indonesian National Police through government regulation Number 43 the Year of 2012. Pamswakarsa tends to be involved in conflict and even has been the new actor/perpretrator against society.

Keywords: conflict, corporation, Lampung, pam swakarsa, paramilitary, violent.
Diagnóstico del conocimiento matemático para la enseñanza sobre docentes en proceso de formación
Authors: Gualdrón Pinto Elgar , Ávila Zárate Adriana Inés , Ordóñez Vargas Saúl Adolfo 
Published: April 2021

Se presenta un trabajo de investigación que tiene como objetivo la caracterización del conocimiento matemático disciplinar para la enseñanza de los estudiantes de Licenciatura en Educación Infantil en dos etapas diferentes de su formación profesional, al ingresar y al culminar sus estudios de licenciatura. La muestra consiste de 119 estudiantes del programa de Licenciatura en Educación Infantil de una universidad privada y una universidad pública distribuidos en cuatro grupos, dos de primer y dos de último semestre. Como instrumento de recolección de datos, se elaboró un cuestionario con veintisiete preguntas tipo Pruebas Saber de matemáticas; en el cual se seleccionaron la misma cantidad (nueve preguntas) para valorar las competencias de razonamiento, comunicación y resolución de problemas; cada una con tres componentes: numérico – variacional, aleatorio, y espacial – métrico.
Finalmente, el análisis de los datos sugiere que los estudiantes de Licenciatura en Educación Infantil de ambas universidades, en su proceso de formación profesional, adolecen de nuevo conocimiento matemático disciplinar para la enseñanza.
Narratives bridge the divide between distant events in episodic memory
Authors: Cohn-Sheehy Brendan I. , Delarazan Angelique I. , Crivelli-Decker Jordan E. , Reagh Zachariah M. , Mundada Nidhi S. , Yonelinas Andrew P. , Zacks Jeffrey M. , Ranganath Charan 
Published: April 2021

AbstractMany studies suggest that information about past experience, or episodic memory, is divided into discrete units called “events.” Yet we can often remember experiences that span multiple events. Events that occur in close succession might simply be linked because of their proximity to one another, but we can also build links between events that occur farther apart in time. Intuitively, some kind of organizing principle should enable temporally distant events to become bridged in memory. We tested the hypothesis that episodic memory exhibits a narrative-level organization, enabling temporally distant events to be better remembered if they form a coherent narrative. Furthermore, we tested whether post-encoding memory consolidation is necessary to integrate temporally distant events. In three experiments, participants learned and subsequently recalled events from fictional stories, in which pairs of temporally distant events involving side characters (“sideplots”) either formed one coherent narrative or two unrelated narratives. Across participants, we varied whether recall was assessed immediately after learning, or after a delay: 24 hours, 12 hours between morning and evening (“wake”), or 12 hours between evening and morning (“sleep”). Participants recalled more information about coherent than unrelated narrative events, in most delay conditions, including immediate recall and wake conditions, suggesting that post-encoding consolidation was not necessary to integrate temporally distant events into a larger narrative. Furthermore, post hoc modeling across experiments suggested that narrative coherence facilitated recall over and above any effects of sentence-level semantic similarity. This reliable memory benefit for coherent narrative events supports theoretical accounts which propose that narratives provide a high-level architecture for episodic memory.
Pembinaan Organisasi Sosial Kemasyarakatan Mengenai Dampak Pandemi Covid-19 Terhadap Budaya Organisasi di Kecamatan Tamansari Kabupaten Bogor
Authors: Gendalasari Gen Gen 
Published: April 2021

Covid-19 telah menjadi pandemi yang menyebabkan terjadinya perubahan di berbagai bidang seperti pendidikan, sosial budaya dan perdagangan. Banyak kebiasaan baru yang harus dilakukan setiap orang untuk menghindari penyebaran virus ini, salah satunya social distancing atau menjaga jarak dengan orang lain, sehingga lebih mengedepankan protokol Kesehatan bagi seluruh masyarakat. Begitupun Perusahaan wajib melakukan perubahan kebijakan lingkungan kerja untuk menjaga jarak sosial bagi setiap individu, sehingga akan menjadi budaya organisasi yang baru dalam tatanan organisasi saat ini.
Kata-kata kunci: Pandemi, Protokol Kesehatan, Budaya organisasi