bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy Complications and Risk of Uterine Rupture: a Study Based on More Than 9 Million Singleton Pregnant Women
Authors: Tao Jing , Mu Yi , Chen Peiran , Xie Yanxia , Liang Juan , Zhu Jun 
Published: April 2021

Abstract
To investigate whether pregnancy complications are associated with increased risk of UR and how that risk changes with gestational age. We obtained all data from China’s National Maternal Near Miss Surveillance System (NMNMSS) between 2012 and 2018. Poisson regression analysis was used to assess the risk of UR with pregnancy complications (preeclampsia, gestational diabetes mellitus, placental abruption, placenta previa and placenta accreta) among 9,502,250 pregnant women. Furthermore, we analyzed the risks of UR with pregnancy complications in different gestational age groups. Compared to women without pregnancy complications, those with different complications (except for preeclampsia) had a 1- to 3-fold greater risk of UR. These associations also persisted in women without previous cesarean delivery. Women with placental abruption or placenta accreta had an increased risk of UR in all gestational age groups, while the increased risk of UR among women with placenta previa was only observed at term. Moreover, an increased risk of UR among women with gestational diabetes mellitus was only observed at 32 to 36 weeks gestation and increased with the offspring’s birth weight. Better quality antenatal care and early intervention for women with these pregnancy complications are needed to minimize the incidence of UR.
Study on the Law of Earth’s Surface Movement on Ultra-long Working Face
Authors: Peng Rui , Meiling Fang , Ruile Ren , Jianming Zhu , Zhao Qifeng , Zhenhua Ouyang 
Published: April 2021

Abstract
The problem of stoping on ultra-long working face is one of challenges for making coal mining safe and efficient. The strong mining effect of surrounding rock induced by long working face mining causes a number of coal or rock dynamic disasters to safe and efficient coal mining. For the purpose of in-depth study of the law of earth’s surface movement on ultra-long working face, this paper, with FLAC3D (numerical simulation software) used to build a numerical model of ultra-long working face, analyzes the law of roof-to-floor strata behaviors in coal bed during mining, and studies the weakening of roof-to-floor parameters in coal bed, bearing pressure and the law of roof caving and rock strata movement; Analyzes the face length effect resulted from the difference in face lengths. It has been recognized that the sphere of influence of bearing pressure changes from small to large and then to small, and changes in distribution of arch bottom and arch height at the plastic failure zone are further intensified over advancing of the working face, moreover, the movement of rock strata is subject to the cumulative influence of the advancing direction of the working face and the face length effect. The above-mentioned research results can serve as a theoretical basis for practical engineering.
Predominance of canine parvovirus 2b in Japan: An epidemiological study during 2014-2019.
Authors: Takano Tomomi , Hamaguchi Shun , Hasegawa Nobuhisa , Doki Tomoyoshi , Soma Takehisa 
Published: April 2021

Abstract
Canine parvovirus-2 (CPV-2) is an important pathogen of domestic dogs and wild canids. In Japan, CPV-2 infection remains one of the most common infection diseases among dogs. We analyzed samples collected between 2014 and 2019 to determine the antigenic variants of CPV-2 among dogs in Japan. Our results demonstrated that the CPV-2b variant was predominant. The CPV-2c variant was not found among our samples. Our findings demonstrate that the distribution of CPV-2 antigenic variants in Japan was more similar to the distribution in Australia compared with that of neighboring countries in Asia.
Neuromorphic Computation With a Single Magnetic Domain Wall
Authors: Ababei Razvan V. , Ellis Matthew O. A. , Vidamour Ian T. , Devadasan Dhilan S. , Allwood Dan A. , Vasilaki Eleni , Hayward Thomas J. 
Published: April 2021

Abstract
Machine learning techniques are commonly used to model complex relationships but implementations on digital hardware are relatively inefficient due to poor matching between conventional computer architectures and the structures of the algorithms they are required to simulate. Neuromorphic devices, and in particular reservoir computing architectures, utilize the inherent properties of physical systems to implement machine learning algorithms and so have the potential to be much more efficient. In this work, we demonstrate that the dynamics of individual domain walls in magnetic nanowires are suitable for implementing the reservoir computing paradigm in hardware. We modelled the dynamics of a domain wall placed between two anti-notches in a nickel nanowire using both a 1d collective coordinates model and micromagnetic simulations. When driven by an oscillating magnetic field, the domain exhibits non-linear dynamics within the potential well created by the anti-notches that are analogous to those of the Duffing oscillator. We exploit the domain wall dynamics for reservoir computing by modulating the amplitude of the applied magnetic field to inject time-multiplexed input signals into the reservoir, and show how this allows us to perform machine learning tasks including: the classification of (1) sine and square waves; (2) spoken digits and (3) non-temporal 2D toy data and hand written digits. Our work lays the foundation for the creation of nanoscale neuromorphic devices in which individual magnetic domain walls are used to perform complex data analysis tasks.
Protocol for Light-Dark and Activity Rhythm Therapy for sleep: Feasibility and acceptability in Schizophrenia spectrum disorders (L-DART FitSz)
Authors: Faulkner Sophie , Bee Penny E. , Drake Richard J. 
Published: April 2021

Abstract
BackgroundSleep problems are common in people with diagnoses of schizophrenia spectrum disorders (> 50%), even during periods of relative stability of psychotic symptoms. Evidence suggests that people living with schizophrenia spectrum disorders are often keen to improve their sleep, but few non-pharmacological sleep treatments are available to patients in specialist mental health services. It has been proposed that occupational therapists may have the relevant skills for the delivery of behavioural sleep interventions. This mixed method, proof-of-concept study aims to assess the feasibility and acceptability of a new intervention, Light-Dark and Activity Rhythm Therapy (L-DART), to improve sleep in people with schizophrenia spectrum disorder diagnoses.MethodsA single group of 10 service users with schizophrenia spectrum diagnoses and self-reported problems with sleep onset, maintenance, timing or quality will be offered L-DART. L-DART will be delivered over 6–9 in person sessions and 3–6 phonecalls by an occupational therapist. Feasibility measures will comprise recruitment and retention logs, fidelity based on session records, adverse effects, and study attrition. Intervention uptake, engagement and adherence will be measured, and barriers to adherence explored. Acceptability will be assessed though quantitative satisfaction ratings and qualitative interviews. Activity patterns and dynamic light exposure will be measured, as well as self-reported sleep, wellbeing and functioning, to inform outcome selection in a larger trial.DiscussionThe findings will inform any necessary modifications to the intervention and its materials, enabling the development of a stage 2 manual and a therapist training package. The results will support the design of a randomised multi-therapist feasibility trial.Trial registrationISRCTN11998005, assigned registration on 17.02.2020
Temperature and Risk of Infectious Diarrhea: A Systematic Review and Meta-analysis
Authors: Liang Mingming , Ding Xiuxiu , Wu Yile , Sun Yehuan 
Published: April 2021

Abstract
There are many studies that have explored the relationship between temperature and the spread of infectious diarrhea (ID), but the results obtained are inconsistent. It is necessary to systematically evaluate the impact of temperature on the incidence of ID. ID is an intestinal infectious disease including cholera, typhoid and paratyphoid fever, bacterial and amebic dysentery, and other infectious diarrhea. This study is based on the PRISMA statement to report this systematic review. We conduct literature searches from CNKI, VIP databases, CBM, PubMed, Web of Science, Cochrane Library and other databases. The number registered in PROSPERO is CRD42021225472. Finally, after searching a total of 4,915 articles in the database and references, a total of 27 studies were included. The number of people involved exceeded 7.07 million. The overall result demonstrated when the temperature rises, there is a significant increase in infectious diarrhea (RRcumulative=1.42, 95%CI:1.07–1.88, RRsingle−day=1.08, 95%CI:1.03–1.14). Subgroup analysis found that the cumulative effect of temperature on the bacillary dysentery group and other diarrhea groups. The result of the single-day effect subgroup analysis was similar to the result of the cumulative effect. And the sensitivity analysis proves that the above results were robust. This systematic review and meta-analysis support that temperature will increase the risk of ID, which is helpful for ID prediction and early warning in the future.
Using Patient Feedback to Adapt Intervention Materials Based on Acceptance and Commitment Therapy for People Receiving Renal Dialysis
Authors: Elander James , Kapadi Romaana , Coyne Emma , Taal Maarten , Selby Nick , Stalker Carol , Mitchell Kathryn 
Published: April 2021

Abstract
Background: Theory-based intervention materials must be carefully adapted to meet the needs of users with specific physical conditions. Acceptance and Commitment Therapy (ACT) has been adapted successfully for cancer, chronic pain, diabetes, irritable bowel syndrome, multiple sclerosis, and a range of other conditions, but not so far for people receiving renal haemodialysis. This paper presents findings from a study to adapt ACT-based intervention materials specifically for renal dialysis. Methods: Draft written materials consisting of four stories depicting fictitious individuals who used ACT-related techniques to help overcome different challenges and difficulties related to dialysis were adapted using a systematic patient consultation process. The participants were 18 people aged 19 to 80 years, with chronic kidney disease and receiving renal dialysis. Individual, semi-structured interviews were conducted to elicit participants’ views about how the content of the draft materials should be adapted to make them more realistic and relevant for people receiving renal dialysis and how the materials should be presented and delivered to people receiving renal dialysis. The interview transcripts were analysed using a qualitative adaptation of the Delphi method in which themes are used as a framework for translating feedback into proposals for modifications.Results: The analysis of patient feedback supported the use of patient stories but suggested they should be presented by video and narrated by real dialysis patients. They also indicated specific adaptations to make the stories more credible and realistic. Participant feedback was translated into proposals for change that were considered along with clinical, ethical and theoretical factors. The outcome was a design for a video-based intervention that separated the stories about individuals from the explanations of the specific ACT techniques and provided greater structure, with material organised into smaller chunks. This intervention is adapted specifically for people receiving renal dialysis while retaining the distinctive theoretical principles of ACT.Conclusions: The study shows the value of consulting patients in the development of intervention materials and illustrates a process for integrating patient feedback with theoretical, clinical and practical considerations in intervention design.
Pectin from Mangifera indica L. cv. Haden residues: Kinetic, thermodynamic, physicochemical, and economical characterization
Authors: Valdivia-Rivera Sergio , Herrrera-Pool Emanuel , Ayora-Talavera Teresa Del Rosario , Lizardi-Jiménez Manuel Alejandro , García-Cruz Ulises , Cuevas-Bernardino Juan Carlos , Cervantez-Uc José Manuel , Pacheco Neith 
Published: April 2021

Abstract

The effect of temperature (60, 70, 80 and 90 ºC) and time (30, 45, 60, 75 and 90 min) on citric acid extraction of Haden mango ( Mangifera indica L . cv. Haden) peel pectin was evaluated in the present study. In order to obtain a better understanding of both the extraction process and the characteristics of the pectin (obtained from an agro-industrial waste) for a future scaling process, the following characterizations were performed: 1) Kinetic, with the maximum extraction times and yields at all evaluated temperatures; 2) thermodynamic, obtaining activation energies, enthalpies, entropies and Gibbs free energies for each stage of the process; 3) physicochemical (chemical analysis, monosaccharide composition, degree of esterification, galacturonic acid content, free acidity, Fourier-transform infrared spectroscopy, thermogravimetric and derivative thermogravimetric analyses) and; 4) economical, of the pectin with the highest yield. The mango Haden peel pectin was found to be characterized by a high-esterified degree (81.81 ± 0.00 %), regular galacturonic acid content (71.57 ± 1.26 %), low protein (0.83 ± 0.05 %) and high ash (3.53 ± 0.02 %) content, low mean viscometric molecular weight (55.91 kDa) and high equivalent weight (3657.55 ± 8.41), which makes it potentially useful for food, pharmaceutical and environmental applications such as delivery system, gelling agent or as an emulsifier.Statement of NoveltyThe novelty of this work lies in the valorization of an agro-industrial waste (Haden mango peel) through the kinetic, thermodynamic, physicochemical, and economic characterization of a product obtained (pectin). This work contributes to laying the groundwork for an industrial scale-up for pectin production in a mango processing industry.
Identification Of Exosomal LncRNAs From Peripheral Blood In Spinal Cord Injury Mouse Model
Authors: Li Jian-an , Shi Ming-peng , Cong Lin , Gu Ming-yu , Chen Yi-heng , Wang Si-yi , Li Zhen-hua , Wei Wan-fu 
Published: April 2021

Abstract
Background

Spinal Cord Injury ( SCI ) is a disease leading to permanent neurological dysfunction. In recent years, exosomes and non-coding RNAs have been considered as potential therapeutic agents for spinal cord injury. Based on ceRNA regulatory network, the role of non-coding RNAs has been paid attention to, and some genes related to the pathological process after spinal cord injury have been found. However, most gene studies only focus on exosomes and non-coding RNAs in spinal cord injury sites, and few genes related to spinal cord injury repair have been found.
Objective

We aimed to identify exosomes and non-coding RNA in peripheral blood after spinal cord injury, and to predict its role in spinal cord injury according to gene expression profiles.
Materials and methods

After successful modeling of spinal cord injury, rat exosomes were extracted from peripheral blood.Western-Blot was used to identify exosomes. After RNA was extracted from exosomes, total transcriptome sequencing and differential gene GO and KEGG Pathway analysis were performed. We selected potential genes for quantitative Real-Time PCR (qRT-PCR) assays and predicted their potential regulatory networks.
Results

The successful establishment of spinal cord injury model was confirmed by Tarlov’s scores, and the extracted exosomes were confirmed by Western-Blot and electron microscopy. Among the significantly differentially expressed lncRNAs, XR_351404, XR_353833, XR_590719, XR_590076, and XR_591455 were associated with miRNA related to repair after spinal cord injury.
Conclusions

The regulatory effect of this network may play a key role in the repair process of SCI. The differential lncRNAs we found may serve as therapeutic targets and diagnostic biomarkers for SCI.
Model Test and Theoretical Analysis of New and Old Embankments Differential Settlement Considering Lateral Deformation
Authors: Lv Gao-hang , Cui Wei , Wang Shu Jian 
Published: April 2021

Abstract
In the embankment widening project, the new embankment will produce large deformation due to the low degree of consolidation, which will affect the stability of the embankment. Obtaining the settlement law of embankment is the premise to ensure the stability of the embankment. In this paper, the deformation law of the new embankment is studied through the embankment model test, and the settlement calculation method of the new embankment is proposed. The model test results show that the new and old embankments have a large settlement difference during the loading process, and the maximum settlement of the new embankment is twice that of the old embankment. The lateral deformation of the new embankment is directly proportional to the vertical deformation, sliding occurs under the ultimate load, and the bearing capacity is lost. Based on the one-dimensional calculation method, the lateral deformation coefficient is introduced, and the two-dimensional embankment settlement formula is obtained. The new embankment is meshed, and the deformation of each node is calculated by the formula, and the difference between the settlement and the model test data is 6.2%, which proves the feasibility and accuracy of the calculation method.
Selectively Targeting Tumor Hypoxia with the Hypoxia-Activated Prodrug CP-506
Authors: Wiel Alexander M.A. van der , Jackson-Patel Victoria , Niemans Raymon , Yaromina Ala , Liu Emily , Marcus Damiënne , Mowday Alexandra , Lieuwes Natasja , Biemans Rianne , Lin Xiaojing , Fu Zhe , Kumara Sisira , Jochems Arthur , Ashoorzadeh Amir , Anderson Robert , Hicks Kevin , Bull Matthew , Abbattista Maria , Guise Christopher , Deschoemaeker Sofie , Thiolloy Sophie , Heyerick Arne , Solivio Morwena , Balbo Silvia , Smaill Jeff , Theys Jan , Dubois Ludwig , Patterson Adam , Lambin Philippe 
Published: April 2021

Abstract
Background

Hypoxia-activated prodrugs (HAPs) are a promising class of antineoplastic agents that can selectively eliminate hypoxic tumor cells. The present study evaluates the hypoxia-selectivity and antitumor activity of CP-506, a DNA alkylating HAP with favorable pharmacological properties.
Methods

Stoichiometry of reduction, one-electron affinity, and back-oxidation rate of CP-506 were characterized by fast-reaction radiolytic methods. In vitro, 2D monolayer and 3D spheroid and multicellular layer cultures were used to investigate the hypoxia-selectivity of CP-506. In vivo, the causal relationship between tumor oxygenation and antitumor effects of CP-506 was assessed. Mice bearing a range of human tumor xenografts were exposed to CP-506 and tumor growth was monitored. A multivariate linear regression model was used to identify factors associated with CP-506 treatment outcome.
Results

Net reduction, metabolism, and cytotoxicity of CP-506 were maximally inhibited at oxygen concentrations above 1 µM (0.1% O2). CP-506 demonstrated cytotoxicity selectively in hypoxic 2D and 3D cell cultures with normoxic/anoxic IC50 ratios up to 203. In vivo, the antitumor effects of CP-506 were selective for hypoxic tumor cells and causally related to tumor oxygenation. CP-506 effectively decreased the hypoxic fraction and inhibited growth of a wide range of hypoxic xenografts. Two well-oxygenated models were refractory to treatment despite intrinsic anoxic sensitivity in vitro. A multivariate regression analysis revealed baseline tumor hypoxia and in vitro sensitivity to CP-506 to significantly correlate with treatment response.
Conclusions

Our results demonstrate that CP-506 selectively sterilizes hypoxic tumor cells and has broad antitumor activity. Our data also indicate that tumor hypoxia and cellular sensitivity to CP-506 are strong determinants of the antitumor effects of CP-506.
Mitigation of the effects of climate change in the agricultural sector of Cyprus, through optimization of benefit
Authors: Economidou Y. , Doula M. K. , Zorpas A. A. 
Published: April 2021

Abstract
Water scarcity has a significant impact on agricultural productivity, and it usually constitutes the main criterion for the continuation of agricultural activity. The Cyprus agri-sector faces increasing challenges since water resources are very limited and particularly susceptible to climate change. As total profit highly depends on cultivation patterns, the present study aims to define the optimal pattern of agricultural crops in Cyprus. A linear programming model is set up to maximize the net profit of annual and permanent crops. As for the constraints, these include limitations on land and water availability under four different scenarios, provided that production secures current consumption of (1) domestic products, (2) domestic and imported products, (3) domestic products but under a 40% decrease in water availability and (4) domestic products but limited to only traditional, tropical and subtropical crops, under a 40% decrease in water availability. The results indicate that when using an optimal cultivation pattern, economic benefit increases by 120%, 62%, 20%, and 48%, based on Scenarios 1, 2, 3 and 4, respectively. Furthermore, the results are considered useful and directly applicable for policy makers to redesign their strategy in light of water scarcity.
Association Between Biofilm Formation Gene Bla exoU and Metallo and
Extend Spectrum Beta-lactamase Production of Multidrug Resistance
Pseudomonas aeruginosa in Clinical Samples
Authors: Ali Fattma Abodi 
Published: April 2021

Background:
The presence of biofilm formation exoU gene is significant challenge to infection control management in hospitals and exposure by Pseudomonas aeruginosa may lead to further spread and development of antimicrobial resistance.

Methods:
Out of 227 samples 40 clinical isolates of P. aeruginosa were collected from patients attending public hospitals ( Rizgary, Teaching hospital, Laboratory center, Raparin, Nanakaly hospitals)in Erbil city/Iraq over a period during 2018 to march 2019 and fully characterized by standard bacteriological procedures and antimicrobial susceptibility test and ESBL has been carried out by Vitek 2 compact system and. by Vitek 2 compact system. The identification has been verified by all isolates as P. aeruginosa by using 16S rDNA with product size (956pb).

Results:
A high rate of resistance was seen against Penicillin and lincomycin and Piperacillin and chloramphenicol and rifampicin (100 %), whereas Imipenem (5%) were found to be the most effective antimicrobial drugs. Of all P. aeruginosa isolates, 30 (75% %) were identified as MDR, approximately 9(22.5%) of isolates were resistant to 9 drugs in burn samples. Quantitative biofilm determination using the Congo red method revealed that 28 isolates (70%) produced biofilm, biofilm production was significantly higher among MDR P. aeruginosa isolates while coproduction of Extended Spectrum β-lactamase (ESBL) together with Metallo β-lactamase (MBL) ESBLs MBLs recorded in (52.5%) of the isolates. Altogether 40 isolates were processed for analysis by PCR assays and showed that 26(70%) of P. aeruginosa isolates harboured the exoU encoding gene with product size (204) pb was more commonly seen in isolates obtained from burn isolates. In addition, exo U gene was significantly associated with the higher MDR (80%), 8 isolates (76.9%)had exoU gene with ESBL and( 65%) had MBL and the same for MDR (80.8%) in samples for burning.

Conclusion:
Our results showed surveillance of P. aeruginosa resistance against antimicrobial and ESBL and MBL is fundamental to monitor trends in susceptibility patterns and appropriately guide clinicians in choosing empirical or directed therapy.