bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inadvertent, intraoperative, non- to minimally displaced periprosthetic humeral shaft fractures in RTSA do not affect the clinical and radiographic short-term outcome
Authors: Hasler Anita , Kriechling Philipp , Passaplan Caroline , Wieser Karl 
Published: June 2021

Abstract
Introduction
Little information is available on the clinical and radiographic outcome of intraoperative, non- to minimally displaced humeral fractures that occur during implantation of a stemmed, reverse shoulder prosthesis but are only recognized on routine postoperative radiographs. The goal of this study is to report the clinical and radiographic outcome for this rarely reported fracture type.

Materials and methods
39 conservatively treated non- to minimally displaced intraoperative periprosthetic humeral fractures after stemmed RTSA were detected from our radiographic database between 1.1.2006 and 31.1.2018. Exclusion criteria were lack of patient consent, preoperative humeral fracture, and revision arthroplasties. Clinical (absolute and relative Constant score, the Subjective Shoulder Value) and radiographic (conventional radiographs) assessment was performed preoperatively, at 6 weeks (only radiographically) and at latest follow-up with a minimum follow-up of 2 years.

Results
35 patient’s with a mean age of 72 years (range 32–88, SD ± 11 years) and a mean follow-up of 53 months (range 24–124, SD ± 31) were included in the study. At latest follow-up, all clinical outcome parameters except external rotation improved significantly. A complication rate of 17% (n:6) was recorded. At 6 weeks after the index surgery, none of the radiographs showed a fracture displacement or a sintering of the stem. At latest follow-up, all fractures were healed and no stem loosening was observed in any of the shoulders.

Conclusions
Non- to minimally displaced intraoperative periprosthetic humeral fractures in RTSA have an incidence of about 5% in this series of mainly uncemented press-fit stems. They generally heal without any further treatment and are not associated with stem loosening or compromise the clinical outcome after primary RTSA. Except slight restriction in the postoperative rehabilitation protocol, no further attention or action is needed.
Sex differences in temperature-related all-cause mortality in the Netherlands
Authors: Folkerts Mireille A. , Bröde Peter , Botzen W. J. Wouter , Martinius Mike L. , Gerrett Nicola , Harmsen Carel N. , Daanen Hein A. M. 
Published: June 2021

Abstract
Purpose
Over the last few decades, a global increase in both cold and heat extremes has been observed with significant impacts on human mortality. Although it is well-identified that older individuals (> 65 years) are most prone to temperature-related mortality, there is no consensus on the effect of sex. The current study investigated if sex differences in temperature-related mortality exist in the Netherlands.

Methods
Twenty-three-year ambient temperature data of the Netherlands were combined with daily mortality data which were subdivided into sex and three age classes (< 65 years, 65–80 years,  ≥ 80 years). Distributed lag non-linear models were used to analyze the effect of ambient temperature on mortality and determine sex differences in mortality attributable to the cold and heat, which is defined as mean daily temperatures below and above the Minimum Mortality Temperature, respectively.

Results
Attributable fractions in the heat were higher in females, especially in the oldest group under extreme heat (≥ 97.5th percentile), whilst no sex differences were found in the cold. Cold- and heat-related mortality was most prominent in the oldest age group (≥ 80 years) and to a smaller extent in the age group between 65–80 years. In the age group < 65 years temperature-related mortality was only significant for males in the heat.

Conclusion
Mortality in the Netherlands represents the typical V- or hockey-stick shaped curve with a higher daily mortality in the cold and heat than at milder temperatures in both males and females, especially in the age group ≥ 80 years. Heat-related mortality was higher in females than in males, especially in the oldest age group (≥ 80 years) under extreme heat, whilst in the cold no sex differences were found. The underlying cause may be of physiological or behavioral nature, but more research is necessary.
Anxiety is associated with unfulfilled information needs and pain at the informed consent consultation of spine surgery patients: a longitudinal study
Authors: Fischbeck Sabine , Petrowski Katja , Renovanz Mirjam , Nesbigall Rebecca , Haaf Julian , Ringel Florian 
Published: June 2021

Abstract
Purpose
Meeting the information needs of patients adequately is of high importance in informed consent consultations in surgery. However, information needs often remain unmet in the informed consent consultation. The aim of this study was to assess anxiety and pain in relation to the patients’ information needs fulfillment perioperatively.

Methods
We applied a question prompt list (QPL) for patients undergoing spine surgery (SN-QPL) before (t1) and a question answering list (SN-QAL) after (t2) the informed consent consultation. The patients additionally completed the “State-Trait Anxiety Operation Inventory” (STOA, cognitive and affective scale) at t1, as well as a pain numerical rating scale (NRS) at t2 and postoperative (t3). We analyzed (1) the association between anxiety, information needs and pain and (2) anxiety and pain scores regarding information needs fulfillment after the consent consultation.

Results
A total of n = 118 patients was included. Affective and cognitive state anxiety was only reduced postoperatively (affective p < .001, cognitive p < .05). The higher trait anxiety was, the more patients longed for information at t1–t3 (t1: r = .58/r = .74, each p < .001), (t2: r = .38/r = .49, each p < .001) and (t3: r = .29, p < .01/r = 34, p < .001). Higher grades of trait anxiety resulted in lower information needs fulfilment. Higher state anxiety levels were associated with higher pain levels. Information needs more often remained unfulfilled in high trait and state anxiety patients.

Conclusion
Patients’ anxiety was associated with (un)fulfilled information needs. Meeting information needs should be optimized in the process of surgeon–patient communication. Adapting the information to the patients’ anxiety levels seem to be an effective way to reduce anxiety.
Thiamine and diabetes: back to the future?
Authors: Beltramo Elena , Mazzeo Aurora , Porta Massimo 
Published: June 2021

AbstractThe first reports of a link between thiamine and diabetes date back to the 1940s. Some years later, a role for thiamine deficiency in diabetic neuropathy became evident, and some pilot studies evaluated the putative effects of thiamine supplementation. However, the administration of thiamine and its lipophilic derivative benfotiamine for the treatment of this complication gained consensus only at the end of the ‘90 s. The first evidence of the beneficial effects of thiamine on microvascular cells involved in diabetic complications dates to 1996: from then on, several papers based on in vitro and animal models have addressed the potential use of this vitamin in counteracting diabetic microangiopathy. A few pilot studies in humans reported beneficial effects of thiamine administration on diabetic nephropathy, but, despite all promising proofs-of-concept, the possible role of thiamine in counteracting development or progression of retinopathy has not been addressed until now. Thiamine is a water-soluble vitamin, rapidly expelled from the body, with no issues of over-dosage or accumulation; unfortunately, it is non-patentable, and neither industry nor independent donors are interested in investing in large-scale randomized controlled clinical trials to investigate its potential in diabetes and its complications. Consequently, science will not be able to disprove a promising hypothesis and, more importantly, diabetic people remain deprived of a possible way to ameliorate their condition.
$$\hbox {CDBTune}^{+}$$: An efficient deep reinforcement learning-based automatic cloud database tuning system
Authors: Zhang Ji , Zhou Ke , Li Guoliang , Liu Yu , Xie Ming , Cheng Bin , Xing Jiashu 
Published: June 2021

AbstractConfiguration tuning is vital to optimize the performance of a database management system (DBMS). It becomes more tedious and urgent for cloud databases (CDB) due to diverse database instances and query workloads, which make the job of a database administrator (DBA) very difficult. Existing solutions for automatic DBMS configuration tuning have several limitations. Firstly, they adopt a pipelined learning model but cannot optimize the overall performance in an end-to-end manner. Secondly, they rely on large-scale high-quality training samples which are hard to obtain. Thirdly, existing approaches cannot recommend reasonable configurations for a large number of knobs to tune whose potential values live in such high-dimensional continuous space. Lastly, in cloud environments, existing approaches can hardly cope with the changes of hardware configurations and workloads, and have poor adaptability. To address these challenges, we design an end-to-end automatic CDB tuning system,$${\texttt {CDBTune}}^{+}$$CDBTune+, using deep reinforcement learning (RL).$${\texttt {CDBTune}}^{+}$$CDBTune+utilizes the deep deterministic policy gradient method to find the optimal configurations in a high-dimensional continuous space.$${\texttt {CDBTune}}^{+}$$CDBTune+adopts a trial-and-error strategy to learn knob settings with a limited number of samples to accomplish the initial training, which alleviates the necessity of collecting a massive amount of high-quality samples.$${\texttt {CDBTune}}^{+}$$CDBTune+adopts the reward-feedback mechanism in RL instead of traditional regression, which enables end-to-end learning and accelerates the convergence speed of our model and improves the efficiency of online tuning. Besides, we propose effective techniques to improve the training and tuning efficiency of$${\texttt {CDBTune}}^{+}$$CDBTune+for practical usage in a cloud environment. We conducted extensive experiments under 7 different workloads on real cloud databases to evaluate$${\texttt {CDBTune}}^{+}$$CDBTune+. Experimental results showed that$${\texttt {CDBTune}}^{+}$$CDBTune+adapts well to a new hardware environment or workload, and significantly outperformed the state-of-the-art tuning tools and DBA experts.
User involvement in adolescents’ mental healthcare: a systematic review
Authors: Viksveen Petter , Bjønness Stig Erlend , Cardenas Nicole Elizabeth , Game Julia Rose , Berg Siv Hilde , Salamonsen Anita , Storm Marianne , Aase Karina 
Published: June 2021

AbstractMore than one out of ten adolescents suffer from mental illness at any given time. Still, there is limited knowledge about their involvement in mental healthcare. Adolescents have the right to be involved in decisions affecting their healthcare, but limited research focuses on their engagement and decision-making. Therefore, this systematic review aims to explore the existing experiences with, the effectiveness of, and safety issues associated with user involvement for adolescents’ mental healthcare at the individual and organizational level. A systematic literature review on user involvement in adolescents’ mental healthcare was carried out. A protocol pre-determined the eligibility criteria and search strategies, and established guidelines were used for data extraction, critical appraisal, and reporting of results. Quantitative studies were analysed individually due to heterogeneity of the studies, while qualitative studies were analysed using thematic synthesis. A total of 31 studies were included in the review. The experiences with user involvement were reported in 24 studies with three themes at the individual level: unilateral clinician control versus collaborative relationship, capacity and support for active involvement, the right to be involved; and two themes at the organizational level: involvement outcomes relevant to adolescents’ needs, conditions for optimal involvement. The effectiveness of user involvement was reported in seven studies documenting fragmented evidence related to different support structures to facilitate adolescents’ involvement. The safety associated with user involvement was not reported in any studies, yet a few examples related to potential risks associated with involvement of adolescents in decision-making and as consultants were mentioned.
On the Negativity of Moduli Spaces for Polarized Manifolds
Authors: Zuo Kang 
Published: June 2021

AbstractGiven a log base space (Y, S), parameterizing a smooth family of complex projective varieties with semi-ample canonical line bundle, we briefly recall the construction of the deformation Higgs sheaf and the comparison map on (Y, S) made in the work by Viehweg–Zuo. While almost all hyperbolicities in the sense of complex analysis such as Brody, Kobayashi, big Picard and Viehweg hyperbolicities of the base U = Y ∖ S (under some technical assumptions) follow from the negativity of the kernel of the deformation Higgs bundle we pose a conjecture on the topological hyperbolicity on U. In order to study the rigidity problem we then introduce the notions of the length and characteristic varieties of a family f : X → Y, which provide an infinitesimal characterization of products of sub log pairs in (Y, S) and an upper bound for the number of subvarieties appearing as factors in such a product. We formulate a conjecture on a characterization of non-rigid families of canonically polarized varieties.
Revisiting the pathogenic mechanism of the GJB1 5’ UTR c.-103C > T mutation causing CMTX1
Authors: Grosz Bianca R. , Svaren John , Perez-Siles Gonzalo , Nicholson Garth A. , Kennerson Marina L. 
Published: June 2021

AbstractThe second most common form of Charcot-Marie-Tooth neuropathy (CMT), X-linked CMT type X1 (CMTX1), is caused by coding and non-coding mutations in the gap junction beta 1 (GJB1) gene. The non-coding GJB1 c.-103C > T mutation (NM_000166.5) has been reported to cause CMTX1 in multiple families. This study assessed the internal ribosomal entry site (IRES) activity previously reported for the rat Gjb1 P2 5’ untranslated region (UTR). Using a bicistronic assay and transfecting RT4 Schwann cells, IRES activity of the human GJB1 P2 5’ UTR was compared to the GJB1 P2 5’ UTR containing either the c.-103C > T mutation or the non-pathogenic c.-102G > A variant. No differences in GJB1 P2 5’ UTR IRES activity were observed between the negative control, the wild-type P2 5’ UTR, the c.-103C > T 5’ UTR or the c.-102G > A 5’ UTR, irrespective of the GJB1 intron being present (p = .429 with intron, and p = .865 without). A theoretical c.-131A > G variant was predicted to result in the same RNA secondary structure as the GJB1 c.-103C > T P2 5’ UTR. However, no significant difference was observed between expression from the wild-type GJB1 P2 5’ UTR and the GJB1 c.-131A > G variant (p = .688). Deletion of the conserved region surrounding the c.-103C > T mutation (c.-108_-103del) resulted in significantly higher expression than the c.-103C > T mutation alone (p = .019), suggesting that the conserved c.-108_-103 region was not essential for translation. The reporter assays in this study do not recapitulate the previously reported GJB1 IRES activity and suggest an alternate pathogenic mechanism for the c.-103C > T CMTX1 non-coding mutation.
Identification of potential rockfall sources using UAV-derived point cloud
Authors: Albarelli D. S. N. A. , Mavrouli O. C. , Nyktas P. 
Published: June 2021

AbstractRecent advances in remote sensing techniques and computer algorithms allow accurate, abundant, and high-resolution geometric information retrieval for rock mass characterization from 3D point clouds. The automatic application of the extracted information for local scale rockfall susceptibility assessment, where discontinuities characteristics play a major role in rocky slope stability, requires step by step logical procedures. This paper presents a novel methodology to use the extracted discontinuity set characteristics for a local scale rockfall susceptibility assessment, tailored for Uncrewed Aerial Vehicle (UAV) data acquisition. The method consists of 4 steps: (i) 3D slope model reconstruction using UAV digital photogrammetry, (ii) automatic characterization of discontinuity sets, (iii) slope stability analysis, and (iv) susceptibility assessment using a new Rockfall Susceptibility Index. The proposed method was applied to a road cut rocky slope in a mountainous area of the Samaria National Park, in Crete Island, Greece. Visual validation indicates that the areas of higher and moderate rockfall susceptibility on the 3D model of the rocky slope are adjacent to rockfall source areas marked by the presence of fallen blocks on the foot of the slope. The proposed methodological workflow presents novelties related to the use of point clouds for the estimation of the Rock Quality Designation (RQD) index, the visualization of discontinuity set spacing, the evaluation of the persistence and the Slope Mass Rating (SMR) index, as well as the incorporation of the persistence of overhangs into the rockfall susceptibility assessment and visualization.
Resistance and the Radical Imagination: A Reflection on the Role of the Critical Criminologist in Social Movements
Authors: Naegler Laura 
Published: June 2021

AbstractAt times of global unrest and the emergence of a wide range of protest movements, recent intra-disciplinary criminological debates on the potentials and limits of resistance suggest a paradoxical trend. Critical criminologists—in particular, those associated with the ultra-realist perspective—have become increasingly skeptical of the idea of “resistance,” itself. In the context of these discussions, scholars have resorted to dismissing oppositional activities—including social movements and their different forms of protest—that are both intended and recognized as resistance. In my contribution to this debate, and in response to Jeff Ferrell’s (2019) article, “In Defense of Resistance,” I provide a critical reflection on the analysis of social movements in both ultra-realist and cultural criminological scholarship. Drawing from my ethnographic research with the (post-)Occupy movement in the United States, I argue that the dismissive reading of social movements’ resistance and the calls for stronger political leadership are the result of a narrow analytical lens applied to movements, their temporalities, and their historical context(s). In addition, I contend that the harsh criticism of social movements by ultra-realists connects to the aim of developing an intellectual leadership concerned with informing social movement practice and strategy “from above.” Here, as I maintain, the theory and practice of militant research, or militancia de investigación, as per the Colectivo Situaciones, challenges this understanding of intellectual leadership. The insights provided by radical collective knowledge production in social movements, and their critique of the institutional frameworks of the neoliberal university, allow for a critical reflection on the role of academia in resistance. This critical reflection can generate possibilities for social movements’ knowledge and radical imaginations to influence academic theorizing.
“Skam” (shame) as Ethical–Political Education
Authors: Strand Torill 
Published: June 2021

AbstractI here explore the educational potential of cinema and TV-series through the eyes of the French philosopher Alain Badiou. To illustrate, I read the Norwegian web-based TV-seriesSkam(shame), which reached out to millions of Nordic teens by a broad distribution, easy access and speaking a language young people could relate to. The series portrays the many faces and ambiguities of shame and shaming embedded in Nordic youth culture. In bringing the question of the pedagogy of cinema and TV-series to the forefront, I here readSkamon three analytical levels. First, to explore the TV-series capability to captivate the viewers through a doubling of the real. Second, to examine Badiou’s idea of cinema as an ontological art, revolving around the question of the relationship between being and appearing. Third, I readSkamanalytically, to consider Badiou’s claim that cinema is a democratic emblem. In sum, what may be the series’ potential for shaping the viewers’ ethical–political awareness?
Toward an integrated framework of corporate venturing for organizational ambidexterity as a dynamic capability
Authors: Weiss Lysander , K. Kanbach Dominik 
Published: June 2021

AbstractIn times of changing business environments, firms must constantly renew their competitive advantage by establishing dynamic capabilities. While often attempting to employ this in corporate venturing activities, they face the challenge of simultaneously exploring new and exploiting existing business opportunities. Examining possible approaches to mastering this feat of ‘organizational ambidexterity’ reveals an extensive but scattered picture. To better integrate this effort by assessing how corporate venturing is linked with organizational ambidexterity in the literature and identifying possible organizational setups, this systematic literature review builds on a sample of 172 studies. Based on different dimensions of dynamic capabilities, the analysis indicates that corporate venturing may take a solely explorative or an exploitative role, or balance both, to directly enable organizational ambidexterity, following a ‘trade-off’, respectively ‘paradox’, school of thought. As a result, this paper identifies four different setups of corporate venturing in an integrated framework, based on the ability and approach to enabling organizational ambidexterity. Here, the synthesis in the proposed framework of the studies examined allows differentiating between not directly ambidextrous separated or integrated corporate venturing and directly ambidextrous contextual or interlinked corporate venturing. As a novel contribution to the fields of strategic management, organizational change and corporate entrepreneurship, this integrated perspective suggests an often overlooked, potentially more strategic role for corporate venturing in the strategic renewal of a firm’s competitive advantage, thus building the basis for further empirical research on strategic corporate venturing approaches for organizational ambidexterity and their application in practice.