bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacto en la comunidad del sector no estatal. Caso de estudio restaurante Nirvana
Authors: Espinosa Manugás Julia Ma. , Romaní Bendig Beatriz , Angulo García Leonardo 
Published: February 2021

El posicionamiento que ha ido adquiriendo en los últimos años el sector no estatal en la capital, con énfasis en la actividad gastronómica, tanto en la estructura de la competencia como en su capacidad generadora de valor, justifica la realización de la presente investigación, que tiene como objetivo, valorar el impacto del restaurante “Nirvana” en la comunidad, para lo cual se empleó un cuestionario en forma de encuesta elaborada a los fines del presente estudio y validada por el coeficiente Alfa de Crombach. La cantidad de encuestados se definió a partir del total de núcleos familiares que habitan en las cuadras más cercanas al restaurante, empleando para ello el programa Sample size carculator. Los resultados se procesaron a través de la estadística paramétrica, el análisis factorial y la prueba de contingencias de Chi cuadrado, empleando el programa SPSS versión 22. Se constató que el restaurante impacta positivamente en la comunidad, básicamente por su contribución a la actividad económica, variable altamente correlacionada con la generación de empleo, condiciones de vida e ingresos personales de los pobladores: De igual modo se observó que la percepción del impacto del restaurante por los encuestados presenta diferencia significativa (p<0,05), siendo valorada de mejor manera por los nacidos en la localidad, los que residen en esta por un mayor periodo de tiempo, los adultos mayores de 60 años, las femeninas y los que habitan más próximo a esta.
La evaluación de la sostenibilidad de los destinos turísticos en su relación con el enfoque a procesos.
Authors: Robert Beatón Martha Omara , Echarri Chávez Maite , Acevedo Suárez José Antonio 
Published: February 2021

El rápido desarrollo de los destinos turísticos y la complejidad de los procesos que en el concurren, exige la búsqueda de herramientas, métodos y modelos para la evaluación de su sostenibilidad. En este sentido el presente trabajo tiene como objetivo valorar la validez de los basamentos del enfoque a procesos para evaluar la sostenibilidad de los destinos turísticos, tomando como base las experiencias en el sector empresarial que refiere la literatura científica consultada. Utilizando fundamentalmente los métodos de síntesis de la bibliografía sobre el tema objeto de estudio, y el análisis comparativo. Los resultados de este análisis demostraron que las herramientas modelos y métodos que se utilizan en la actualidad no permiten evaluar la sostenibilidad de los destinos desde un enfoque interdimensional, intradimensional y multidimensional que integre las dinámicas complejas que se producen en los mismos, sentando las bases para realizar investigaciones desde otras áreas del conocimiento en la búsqueda de instrumentos dirigidos a reconocer y a comprender la visión holística de la sostenibilidad en los destinos turísticos.
Enhancement of natural convection heat transfer in concentric annular space using inclined elliptical cylinder
Authors: Laidoudi Houssem 
Published: February 2021

The governing equations of continuity, momentum and energy are numerically solved to study the laminar natural convection heat transfer of Newtonian fluid confined within two concentric cylinders. The inner cylinder is elliptical cross-section with different aspect ratio E = 0.1 to 0.5 and it is considered to be hot, whereas the outer cylinder is circular and it is supposed to be cold. The annular spacing between the cylinders is defined based on radii ratio (RR = 2.5). Also, the inner cylinder is inclined with an inclination angle (θ = 0 to 90). The main purpose of this study is to determine the effects of inclination angle (θ = 0° to 90°), aspect ratio of inner cylinder (E = 0.1 to 0.5), Prandtl number (Pr = 0.71 and 7.01) and Rayleigh number (Ra = 103 to 105) on fluid flow and heat transfer rate. The flow patterns and temperature distributions are potted in terms of streamlines and isotherms respectively. The obtained results showed that increase in inclination angle enhances the heat transfer rate of inner cylinder for all values of aspect ratio. Also, for the inclination angle (θ = 90°), the decrease in aspect ratio (E) improves the heat transfer rate of inner cylinder.
Tenda do abraço: Uma metodologia de cuidado guiada pelo afeto
Authors: Costa Jackeline de Freitas , Nelson Isabel Cristina Amaral de Sousa Rosso , Couto Gleiber , França Raiane Caroline da Silva 
Published: February 2021

O presente trabalho tem como principal objetivo apresentar a Tenda do Abraço como uma metodologia de cuidado sistematizada no âmbito das Práticas Integrativas e Complementares em Saúde, dentro uma abordagem das Vivências Lúdicas Integrativas. É uma pesquisa de método qualitativo, foi realizada uma pesquisa-ação existencial. O público-alvo foram 48 estudantes da Faculdade de Enfermagem – FAEN da Universidade Estadual do Rio Grande do Norte - UERN. A tenda do abraço é uma metodologia itinerante de cuidado que evidencia a necessidade de cultivar novos olhares para si e para o outro, oportunizando momentos de cuidado, escuta, fala e toques. Por meio de um roteiro não engessado em que os sujeitos têm a possibilidade de cuidar de si e perceber a necessidade do cuidado com o outro, com o aparato das PICS. A Tenda do Abraço perpassa quatro etapas principais: acolhimento afetivo; tecendo saberes; conexões e reflexões; cooperação e autocuidado. A Tenda do Abraço apresentou-se como uma metodologia de cuidado humanescente, sistematizada e potente para conexão consigo e com o outro, melhorando a qualidade das interações interpessoais dos universitários.
Duration of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome Treated With New Generation Stents: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhang Wen-Jiao , Qiao Xuan , Guo Wen-Fen , Liang Xi-Ying , Li Yan , Wang Zhi-Lu 
Published: February 2021

Background and Objective: The optimum duration of dual antiplatelet therapy (DAPT) remains uncertain in patients with acute coronary syndrome treated with new generation stents. This meta-analysis was performed to investigate ischemia and bleeding outcomes with different DAPT strategies.Methods: PubMed, Embase, Cochrane and Web of science from inception to May 27, 2020, were systematically searched. Randomized controlled trials were included to compare short-term (6 months or less) with standard (12 months) DAPT in patients with acute coronary syndrome treated with new generation stents. The primary endpoints were myocardial infarction, definite or probable stent thrombosis and major bleeding. The secondary endpoints included all-cause death, cardiovascular death, stroke, target vessel revascularization and net adverse clinical events. Random effect model and fixed effect model were used to calculate the odds ratio (OR) and 95% confidence interval (CI) of each endpoint.Results: Four randomized controlled trials and seven subgroup analyses of larger randomized controlled trials, including a total of 21,344 patients with acute coronary syndrome, met our inclusion criteria. The shorter DAPT was associated with significantly lower major bleeding compared with the standard DAPT (OR 0.71, 95% CI 0.56–0.90, P = 0.005, I2 = 25%), while without increasing the risk of myocardial infarction (OR 1.18, 0.88–1.58, P = 0.28, I2 = 20%), definite or probable stent thrombosis (OR 1.60, 0.98–2.59, P = 0.06, I2 = 0%). No significantly difference was observed in the risk of all-cause death (OR 0.96, 0.72–1.27, P = 0.76, I2 = 2%), cardiovascular death (OR 0.91, 0.62–1.33, P = 0.62, I2 = 0%), stroke (OR 0.84, 0.54–1.30, P = 0.43, I2 = 0%), target vessel revascularization (OR 1.14, 0.84–1.55, P = 0.41, I2 = 8%), and net adverse clinical events (OR 0.93, 0.80–1.07, P = 0.3, I2 = 18%) between the two groups.Conclusions: In patients with acute coronary syndrome treated with new generation stents, the shorter DAPT leads to a marked reduction in the risk of major bleeding compared with the standard DAPT. This benefit is achieved without increasing the risk of mortality or ischemic outcomes. The study protocol was registered in PROSPERO (CRD42020189871).
Association Between Lipoprotein(a) and Peri-procedural Myocardial Infarction in Patients With Diabetes Mellitus Who Underwent Percutaneous Coronary Intervention
Authors: Liu Yupeng , Wang Wenyao , Song Jingjing , Zhang Kuo , Xu Bo , Li Ping , Shao Chunli , Yang Min , Chen Jing , Tang Yi-Da 
Published: February 2021

BackgroundHigh lipoprotein(a) (Lp[a]) levels are associated with increased risks of cardiovascular events in Percutaneous Coronary Intervention (PCI) patients with diabetes mellitus (DM). Peri-procedural myocardial infarction (PMI) occurs commonly during the PCI, whereas the relationship between Lp(a) and PMI remains unclear. Our study aimed to evaluate the association between Lp(a) value and the incidence of PMI in a larger-scale diabetic cohort undergoing PCI throughout 2013.MethodsA total of 2,190 consecutive patients with DM were divided into two groups according to the median Lp(a) level of 175 mg/L: Low Lp(a) group (N = 1095) and high Lp(a) group (N = 1095). PMI was defined based on the 2018 universal definition of myocardial infarction.ResultsPatients with high Lp(a) levels exhibited higher rates of PMI compared to those with low Lp(a) levels (2.3% versus 0.8%, P = 0.006). The multivariable logistic analysis showed that PMI was independently predicted by Lp(a) as a dichotomous variable (OR 2.64, 95%CI 1.22–5.70) and as a continuous variable (OR 1.57, 95% CI 1.12–2.20). However, further investigation found that this association was only maintained in men, whose Lp(a) levels were significantly associated with the frequency of PMI, both as a dichotomous variable (OR 3.66, 95%CI 1.34–10.01) and as a continuous variable (OR 1.81, 95%CI 1.18–2.78). Lp(a) wasn’t a risk factor of PMI in women.ConclusionsHigh Lp(a) levels had forceful correlations with the increased frequency of PMI in male diabetic patients undergoing PCI. Lp(a) might act as a marker of risk stratification and a therapeutic target to reduce PCI-related ischemic events.
Efficacy and Tolerability of Nintedanib in Idiopathic-Inflammatory-Myopathy-Related Interstitial Lung Disease: A Pilot Study
Authors: Liang Junyu , Cao Heng , Yang Yang , Ke Yini , Yu Ye , Sun Chuanyin , Yue Lihuan , Lin Jin 
Published: February 2021

Objectives: To initially clarify the efficacy and tolerability of nintedanib in patients with idiopathic-inflammatory-myopathy-related interstitial lung disease (IIM-ILD).Methods: A retrospective, real-world analysis was conducted in IIM-ILD patients who regularly received outpatient visit or hospitalization from January 2018 to March 2020 in three centers. And the patients were divided into two groups depending on presence or absence of nintedanib therapy. Comparisons, Kaplan-Meier survival analysis and propensity score matching were made to identify difference in time to death from any cause, incidence of rapidly progressive interstitial lung disease (RP-ILD) and comorbidity of pulmonary infection between the two groups. The following logistic regression analyses and Cox proportional-hazard regression analyses were used to verify the therapeutic value of nintedanib as well as clinical significance of other factors. Adverse events were descriptively recorded.Results: Thirty-six patients receiving nintedanib therapy and 115 patients without use of nintedanib were included. Before and after propensity score matching, the primary comparisons revealed better survival (P = 0.015, P = 0016, respectively) and lower incidence of RP-ILD (P = 0.017, P = 0.014, respectively) in patients with nintedanib therapy. Logistic regression analysis identified that disease activity (P &lt; 0.001), percent-predicted diffusing capacity of the lung for carbon monoxide (DLCO%, P = 0.036), nintedanib therapy (P = 0.004, OR value = 0.072) and amyopathic dermatomyositis (ADM, P = 0.012) were significantly correlated with RP-ILD. Cox proportional hazards regression analysis suggested that disease activity (P &lt; 0.001), anti-MDA5 antibody (P &lt; 0.001) and nintedanib therapy (P = 0.013, HR value=0.268) were significantly associated with survival of IIM-ILD patients. Similar results can also be seen in analyses after propensity score matching. In the 36 patients with nintedanib therapy, diarrhea was the most common adverse event (44.4%) and hepatic insufficiency contributed to most dosage reduction (44.4% of nine patients) or therapy discontinuation (60.0% of five patients).Conclusions: Nintedanib was found to reduce incidence of RP-ILD and improve survival in IIM-ILD patients in a real-world setting. Anti-MDA5 antibody could be taken as a risk factor for unfavorable outcome. ADM was significantly correlated with occurrence of RP-ILD. In addition to the most frequent diarrhea, hepatic insufficiency was closely related to dosage reduction or therapy discontinuation.
Cerebral Metabolite Concentrations Are Associated With Cortical and Subcortical Volumes and Cognition in Older Adults
Authors: Williamson John B. , Lamb Damon G. , Porges Eric C. , Bottari Sarah , Woods Adam J. , Datta Somnath , Langer Kailey , Cohen Ronald A. 
Published: February 2021

BackgroundCerebral metabolites are associated with different physiological processes in brain aging. Cortical and limbic structures play important roles in cognitive aging; however, the relationship between these structures and age remains unclear with respect to physiological underpinnings. Regional differences in metabolite levels may be related to different structural and cognitive changes in aging.MethodsMagnetic resonance imaging and spectroscopy were obtained from 117 cognitively healthy older adults. Limbic and other key structural volumes were measured. Concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) were measured in frontal and parietal regions. Neuropsychological testing was performed including measures of crystallized and fluid intelligence and memory.ResultsNAA in the frontal voxel was associated with limbic and cortical volumes, whereas Cho in parietal cortex was negatively associated with hippocampal and other regional volumes. Hippocampal volume was associated with forgetting, independent of age. Further, parietal Cho and hippocampal volume contributed independent variance to age corrected discrepancy between fluid and crystallized abilities.ConclusionThese findings suggest that physiological changes with age in the frontal and parietal cortices may be linked to structural changes in other connected brain regions. These changes are differentially associated with cognitive performance, suggesting potentially divergent mechanisms.
Integrative Analysis of Complement System to Prognosis and Immune Infiltrating in Colon Cancer and Gastric Cancer
Authors: Bao Dandan , Zhang Chenghao , Li Longlong , Wang Haihong , Li Qiuyan , Ni Leilei , Lin Yinfeng , Huang Rong , Yang Zhangwei , Zhang Yan , Hu Yiren 
Published: February 2021

BackgroundThe complement system acts as an integral part of the innate immune response, which acts primarily to remove pathogens and injured cells. Emerging evidence has shown the activation of the immune regulatory function of complements in the tumor microenvironment (TME). We revealed the expression levels of various complements in human cancers and their role in tumor prognosis and immune infiltration.MethodsThe differential expression of complements was exploredviathe Tumor Immune Estimation Resource (TIMER) site and the Oncomine database. To investigate whether these differentially expressed complements have correlation with the prognosis of gastric cancer (GC) and colon cancer, their impact on survival was assessed using the PrognoScan database and Kaplan-Meier plotter. The correlations between complements and tumor immune-infiltrating levels and immune gene markers were statistically explored in TIMER based on Spearman’s correlation coefficients andp-values.ResultsIn two colon cancer cohorts, an increased expression level of DAF (CD55) has statistically significant correlation with poor disease-free survival (DFS). High C3, CR4, and C5aR1 expression levels were significantly related with poor prognosis in GC patients. In addition, C3, CR4, and C5aR1 expression was positively related to the tumor purity and infiltration levels of multiple immune cells in stomach adenocarcinoma (STAD). Moreover, the expression levels of C3, CR4, and C5aR1 were also strongly correlated with various immune marker sets, such as those of tumor-associated macrophages (TAMs), M1 and M2 macrophages, T cell exhaustion, Tregs, and DCs, in STAD. Additionally, CD55 has positive correlation with few immune cell infiltration levels in colon adenocarcinoma (COAD), but its correlation with immune marker sets was not statistically significant.ConclusionThese findings confirm the relationship between various complements and tumor prognosis and immune infiltration in colon cancer and GC. CD55 may serve as an indicator on the survival prognosis of patients with colon cancer. Furthermore, as biomarkers for poor prognosis in GC, complements C3, CR4, and C5aR1 may provide potential biological targets for GC immunotherapy.
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome
Authors: Wei Chengcong , Guo Shenquan , Liu Wenchao , Jin Fa , Wei Boyang , Fan Haiyan , Su Hengxian , Liu Jiahui , Zhang Nan , Fang Dazhao , Li Guangxu , Shu Shixing , Li Xifeng , He Xuying , Zhang Xin , Duan Chuanzhi 
Published: February 2021

Inflammation is typically related to dysfunction of the blood-brain barrier (BBB) that leads to early brain injury (EBI) after subarachnoid hemorrhage (SAH). Resolvin D1 (RVD1), a lipid mediator derived from docosahexaenoic acid, possesses anti-inflammatory and neuroprotective properties. This study investigated the effects and mechanisms of RVD1 in SAH. A Sprague-Dawley rat model of SAH was established through endovascular perforation. RVD1was injected through the femoral vein at 1 and 12 h after SAH induction. To further explore the potential neuroprotective mechanism, a formyl peptide receptor two antagonist (WRW4) was intracerebroventricularly administered 1 h after SAH induction. The expression of endogenous RVD1 was decreased whereas A20 and NLRP3 levels were increased after SAH. An exogenous RVD1 administration increased RVD1 concentration in brain tissue, and improved neurological function, neuroinflammation, BBB disruption, and brain edema. RVD1 treatment upregulated the expression of A20, occludin, claudin-5, and zona occludens-1, as well as downregulated nuclear factor-κBp65, NLRP3, matrix metallopeptidase 9, and intercellular cell adhesion molecule-1 expression. Furthermore, RVD1 inhibited microglial activation and neutrophil infiltration and promoted neutrophil apoptosis. However, the neuroprotective effects of RVD1 were abolished by WRW4. In summary, our findings reveal that RVD1 provides beneficial effects against inflammation-triggered BBB dysfunction after SAH by modulating A20 and NLRP3 inflammasome.
The Interpersonal Mindfulness in Parenting Scale in Mothers of Children and Infants: Factor Structure and Associations With Child Internalizing Problems
Authors: Burgdorf Virginia , Szabó Marianna 
Published: February 2021

Objectives: Mindful parenting, measured by the Interpersonal Mindfulness in Parenting scale (IMP), is beneficial for parents and children. However, the IMP has not been validated in English-speaking parents. Further, little is known about whether mindful parenting is similar in parents of children vs. infants, or how it reduces child internalizing problems. We sought to validate the IMP in English-speaking mothers of children and infants, and to examine relationships between the facets of mindful parenting, child internalizing problems and parent variables related to internalizing.Methods: Using confirmatory factor analyses, we examined the fit of various models of mindful parenting in English-speaking community-recruited mothers of children aged 3–18 years (n = 396) and infants aged 0–2 years (n = 320). We used regression analyses to investigate relationships between the facets of mindful parenting, child internalizing problems, and parent variables including parental experiential avoidance, unhelpful beliefs about child anxiety and accommodation of child anxiety.Results: Mindful parenting can be measured in English-speaking mothers, using either a 5- or 6-factor, 29-item version of the IMP. These versions of the IMP operate similarly for mothers of children and infants. Child internalizing problems and related parent variables were best predicted by non-judgmental acceptance of parenting in mothers of children, and emotional self-awareness and non-reactivity in mothers of infants.Conclusions: The IMP is a valid measure of mindful parenting in English-speaking mothers of children and infants. Mindful parenting predicts child internalizing problems and related parent variables, suggesting that mindful parenting programs could benefit families of children with internalizing problems, potentially by reducing parental experiential avoidance, unhelpful beliefs about or accommodation of child anxiety.
Perancangan Sistem Informasi Platform Pencarian Kerja Pada PT.Wira Karya Indonesia
Authors: Haryanto Haryanto , Wahyutama Muhammad Fathurrochman , Damayanti Ullya' Maulida , Natasyah Nabilla , Amelliani Amelliani 
Published: February 2021

Perkembangan teknologi yang sangat berpengaruh besar pada aktifitas kegiatan operasional perusahaan adalah teknologi sistem informasi. Salah satunya adalah kegiatan proses pencarian kerja. PT. WIRA KARYA INDONESIA adalah suatu perusahaan yang bergerak dibidang barang dan jasa yang bersifat penyalur tenaga kerja outsorcing. Sistem yang berjalan saat ini masih bersifat manual, dalam mencari informasi lowongan kerja biasanya pelamar mendatangi perusahaan untuk melihat papan pengumuman. Proses penyimpanan data calon pelamar hingga calon perusahaan yang ingin bekerja sama masih menggunakan kertas-kertas atau software microsoft word, sedangkan dalam pembuatan laporan menggunakan software microsoft excel. Hal ini menyebabkan sering terjadinya kehilangan proses data lamaran dan membutuhkan waktu yang cukup lama, sehingga data yang dihasilkan tidak efektif dan efisien. Metode penelitian yang digunakan adalah pengumpulan data melalui : observasi, wawancara, dan literatur review (studi pustaka). Untuk metode analisis menggunakan metode analisis Business Model Canvas (BMC) dan metode PIECES. Sistem ini dibuat dengan menggunakan perancangan model UML (Unified Modelling Language), menggunakan bahasa pemrograman PHP, menggunakan framework CI, Mysql untuk pembuatan database, Sublime Text 3 untuk membuat desain atau tampilan, Xampp sebagai server atau penghubung bahasa pemrograman dan metode pengujian yang digunakan yaitu metode Black Box Testing. Hasil yang didapat dari penelitian ini adalah sebuah sistem informasi platform pencarian kerja yang membantu PT. WIRA KARYA INDONESIA, calon pelamar dan perusahaan yang bekerja sama dalam mencari dan memberikan informasi perihal ketenagakerjaan.

Kata Kunci: Platform, outsourcing, BMC.