bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of the low-medium temperature hot springs around Nanjing, China
Authors: Ma Jun , Zhou Zhifang 
Published: July 2021

Abstract
The exploration of the origin of hot spring is the basis of its development and utilization. There are many low-medium temperature hot springs in Nanjing and its surrounding karst landform areas, such as the Tangshan, Tangquan, Lunshan, and Xiangquan hot springs. This article discusses the origin characters of the Lunshan hot spring with geological condition analysis, hydrogeochemical data, and isotope data. The results show that the hot water is SO4–Ca type in Lunshan area, and the cation content of SO4 is high, which are related to the deep hydrogeological conditions of the circulation in the limestone. Carbonate and anhydrite dissolutions occur in the groundwater circulation process, and they also dominate the water–rock interaction processes in the geothermal reservoir of Lunshan. The hot water rising channels are deeply affected by the NW and SN faults. Schematic diagrams of the conceptual model of the geothermal water circulation in Lunshan are plotted. The origin of Tangshan, Tangquan, and Xiangquan hot springs are similar to the Lunshan hot spring. In general, the geothermal water in karst landforms around Nanjing mainly runs through the carbonate rock area and is exposed near the core of the anticlinal structure of karst strata, forming SO4–Ca/SO4–Ca–Mg type hot spring with the water temperature less than 60°C. The characters of the hot springs around Nanjing are similar, which are helpful for the further research, development, and management of the geothermal water resources in this region.
Insulin-like Growth Factor Axis Genetic Score and Sports Excellence
Authors: Ben-Zaken Sigal , Meckel Yoav , Nemet Dan , Eliakim Alon 
Published: July 2021

Abstract
Ben-Zaken, S, Meckel, Y, Nemet, D, and Eliakim, A. Insulin-like growth factor axis genetic score and sports excellence. J Strength Cond Res 35(9): 2421–2426, 2021—It has been suggested that IGF1 polymorphisms associated with circulating IGF1 levels may be linked to elite short-distance running performance. This study assessed genetic score based on 6 polymorphisms related to the Insulin-like growth factor axis (rs7136446, rs35767, rs6220, rs680, rs2854744, and rs1805086) among elite Israeli runners and swimmers. One hundred sixty-one track and field athletes (123 men and 38 women, age 17–50 years) and 94 swimmers (61 men and 33 women, age 16–49 years) participated in the study. Athletes were divided into short-distance runners (SDRs, major event: 100–200-m sprints and jumps, n = 63) and long-distance runners (LDRs, major event: 5,000 m and marathon, n = 98). Swimmers were divided into short-distance swimmers (SDSs, major event: 50–100 m, n = 44) and long-distance swimmers (LDSs, major event: 400–1,500 m, n = 50). Groups were subdivided into top-level and national-level athletes. We calculated the IGF genetic score (IGF-GS) of all the subjects on a 0–100 scale. Top-level SDRs' mean IGF-GS (30.8 ± 11.7) was significantly higher (p < 0.006) compared with national-level SDRs' (20.5 ± 11.3) and top-level SDSs' (19.9 ± 8.5). Subjects with IGF-GS >25 had an increased odds ratio (OR) of being elite-level SDRs (OR: 4.2; 95% confidence interval: 0.68–26.09; p < 0.001). In summary, a combined assessment of 6 single-nucleotide polymorphisms, all known to modulate circulation IGF1 levels, was associated with a higher genetic score among SDRs, emphasizing the importance of the IGF system to land speed sports events but not to swimming events. Whether the IGF-GS may be used for selection of elite-level sprinters in early stages of their athletic career needs to be further investigated.
Los niveles argumentativos y su relación con los modelos explicativos del concepto de circuitos eléctricos
Authors: Rodríguez Oviedo Edwin , Patiño Franco Yoany Andrés 
Published: July 2021

El propósito central de la investigación que se presenta en este artículo fue promover los procesos argumentativos a partir de los modelos explicativos que existen sobre el concepto de circuitos eléctricos e identificar las relaciones que se pueden establecer entre los procesos argumentativos, entendidos a partir de los niveles de argumentación, y los modelos explicativos de dicho concepto en los estudiantes de grado 11. La investigación es descriptiva-comprensiva, realizada en tres momentos: en el momento 1, de ubicación o diagnóstico, se identificaron los modelos explicativos iniciales de los estudiantes que hicieron parte de este estudio y se determinó su nivel de argumentación; en el momento 2, de desubicación o intervención, se aplicó una unidad didáctica diseñada para intervenir los niveles argumentativos y los modelos explicativos del concepto de circuitos eléctricos de los estudiantes; finalmente en el tercer momento de reenfoque o cierre, se realizó un análisis de los cambios en los modelos explicativos y de los niveles argumentativos que utilizan para explicar el concepto sobre circuitos eléctricos después de la aplicación de la unidad didáctica. Se concluye que promover las prácticas argumentativas en el aula de ciencias, implica reconocer que la argumentación además de ser una actividad social, puede cualificar los procesos de aprendizaje de los conceptos.
Factors Influencing the Software Development Process in Small Scale Industries
Authors: Dr. Dipti Kumari Irfan Ahmad Khan, 
Published: July 2021

Software development is a complex process which is divided into many phases. According to the software type and industries the development process is restructured. During the entire development what are the main factors which is influencing the process and affecting the quality. The main objective of this study is to focus on factors influencing the development process and how it affects the small scale industries after coming in to the real practice.
Entire Software development is a layered process in which different factors are responsible to get the best products. This paper is focused on different technical and non-technical influencing factors which give major impact on the software quality. With influencing factors, their applicability in small scale industries also studied.
Three important technical factors i.e. SDLC model and its principles, Cost estimation and Risk parameter whereas two important influencing factors in non-technical.i.e. success factors and environmental factors. Non-technical factors more influencing than technical factors.
All technical and non-technical factors have their own role but to apply all these quality parameters in small scale industries we need to make them more easy for their applicability. If quality development process and its parameters are tuned to easy and affordable level more businessmen will shift from manual working environment to the digital working environment.
Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered?
Authors: Best Eleanor 
Published: July 2021

PICO question
In reducing surgical recovery time in rabbits (Oryctolagus cuniculus), should doses exceeding 0.2 mg/kg of oral meloxicam be given and is twice daily administration more effective than a single daily dose?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Nine papers were critically reviewed, yet no studies were found to directly investigate the effects of twice daily dosing with meloxicam postoperatively in rabbits. There were five descriptive, non-comparative case series; two nonblinded parallel group randomised control trials; one blinded, placebo-controlled parallel group randomised trial and one prospective, randomised crossover trial
Strength of evidence
Weak
Outcomes reported
The current recommended oral dose of meloxicam in rabbits of 0.2–0.3 mg/kg once a day was consistently described as inadequate for postoperative analgesia following surgery (Delk et al., 2014). Instead, higher doses of 1–1.5 mg/kg were required to reach a similar peak plasma concentration as found to be clinically effective in other species, such as canines, and provide a better degree of analgesia in rabbits (Montoya et al., 2004; and Delk et al., 2014). Although no studies were found evaluating twice daily administration of meloxicam, the available evidence suggests a dose exceeding 0.2–0.3 mg/kg daily is required for adequate postoperative analgesia in rabbits. Whether this increased dose could be given twice daily should be investigated, providing scope for future research
Conclusion
Further studies are required to directly assess the benefits of twice daily oral meloxicam. However, it is possible that a dose exceeding 0.2–0.3 mg/kg is required and therefore higher doses should be considered in these studies

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
UJI FITOKIMIA TUMBUHAN JELATANG GAJAH (Dendrocnide stimulans) DI KAWASAN HUTAN DENGAN TUJUAN KHUSUS UNIVERSITAS LAMBUNG MANGKURAT
Authors: Rahman Rahman , Thamrin Gusti Abdul Rahmat , Kurdiansyah Kurdiansyah 
Published: July 2021

The purpose of this study was to qualitatively identify active chemical compounds, namely the content of alkaloids, flavonoids, steroids, triterpenoids, tannins, saponins, and quinones, in the roots, bark and leaves of Jelatang Gajah. The method used is phytochemical screening by identifying using various active compounds in the simplicia of the Jelatang Gajah plant. Flavonoid chemical compounds in this test were not detected, because the solution did not change color. Steroid chemical compounds from 3 (three) times the repetition of the section show a strong / sharp indication value (++) which is indicated by a dark red color change in the phytrate. Triterpenoids were not detected in the three simplicia, the phytrate that had been made did not change color, indicating the presence of triterpenoid compounds. The result of the (+) value in triterpenoid compounds was indicated by a change in green color. Tests for tannin compounds in the elephant nettle plant study found a weak indication (+) in leaf and bark simplicia, while in the simplicia of tannin roots it was not detected (-). Tujuan dari penelitian ini untuk mengidentifikasi secara kualitatif kandungan alkaloid, flavonoid, steroid, triterpenoid, tanin, saponin, dan quinon, pada bagian akar, kulit, dan daun jelatang gajah. Metode yang digunakan yaitu skrining fitokimia dengan mengidentifikasi menggunakan berbagai senyawa aktif pada simplisia tumbuhan Jelatang Gajah. Senyawa kimia flavonoid pada pengujian ini tidak terdeteksi, karena larutan tersebut tidak terjadi perubahan warna. Senyawa kimia steroid dari 3 (tiga) kali ulangan bagian tersebut menunjukkan nilai indikasi kuat/tajam (++) yang ditunjukkan dengan adanya perubahan berwana merah pekat pada fitrat tersebut. Triterpenoid tidak terdektesi pada ketiga simplisia, fitrat yang telah dibuat tidak terjadi perubahan warna yang menunjukkan adanya senyawa triterpenoid. Hasil nilai (+) pada senyawa triterpenoid ditandai dengan terjadinya perubahan warna hijau.Pengujian senyawa tanin pada penelitian tumbuhan jelatang gajah ini ditemukannya indikasi lemah (+) pada simplisia daun dan kulit, sedangkan pada simplisia akar tanin tidak terdeteksi (-).
Evaluation of Breast Vascular Calcifications as a Predictor for Coronary Artery Calcification
Authors: Bazhenova D. A. , Puchkova O. S. , Mershina E. A. , Sinitsyn V. E. 
Published: July 2021

Background. Cardiovascular diseases are one of the main causes of death among women, and current prevention paradigms may not be sufficient in this group. In this context, it has been suggested that the detection of breast vascular calcifications can improve the screening and assessment of the risk of cardiovascular diseases in apparently healthy women.Objective: to study the role of breast vascular calcifications as a potential predictor for coronary artery calcification. Material and methods. Examinations were made in 123 patients who underwent digital mammography and cardiac computed tomography to estimate a coronary artery calcium score.Results. The use of the Wilcoxon-Mann-Whitney W-test for abnormal distribution showed a relationship between the presence of breast vascular calcifications and calcium score (p< 0.001), and that between aortic wall calcification and calcium score (p< 0.001).Conclusion. Breast vascular calcifications detected by mammography are an indicator of a higher frequency of coronary artery calcification and, apparently, a predictor for the increased risk of cardiovascular disease.
The effect of paternalist leadership style of principals on the professional burnout of special education teachers
Authors: Küçükgöz Mehmet 
Published: July 2021

This study was applied to determine whether the paternalist leadership of school principals affected the burnout levels of special education teachers. The research was carried out with mixed method. 192 teachers participated in the quantitative dimension and 25 teachers and 25 principals participated in the qualitative dimension. Paternalist Leadership Scale, Maslach Burnout Scale and Semi-Structured Question Set were used. In the research, it was determined that teachers' perception of paternalist leadership is high and their burnout levels are low. It was determined that variables of gender, age and working year did not make a significant difference on teachers' paternalist leadership perception. However, these variables cause a significant difference on teachers' professional burnout. It was determined that there was a moderately negative relationship between teachers' paternalist leadership perceptions and their burnout. As the paternalist leadership levels of the principals’ increase, the burnout of the teachers decreases. It was revealed in qualitative findings that teachers define their principals just like a paternalist leader using father and boss metaphors, and the benevolent attitudes of the principals reduce teachers' burnout. A supportive result in qualitative findings is this; it was determined that the paternalist leadership style of principals prevented insensitivity from burnout dimensions in teachers.
Comparative Analysis of the Immunogenic Activity of the Plague Vaccine Depending on the Growing Medium
Authors: Gostishcheva S. E. , Abzaeva N. V. , Rakitina E. L. , Ponomarenko D. G. , Kostyuchenko M. V. , Katunina L. S. , Logvinenko O. V. , Ivanova G. F. , Kurilova A. A. 
Published: July 2021

The aim was to carry out a comparative analysis of the immunogenic activity of the live plague vaccine obtained on various nutrient media.Materials and methods. The subject of the study was the blood of outbred white mice immunized with a series of live plague vaccine based on Yersinia pestis EV NIIEG strain, produced using experimental and regulated nutrient media. The immunogenic activity of vaccines was studied through flow cytometry. The intensity of antigen-reactivity of lymphocytes was determined in cell tests in vitro, analyzing the early activation marker CD25+ . For the specific activation of lymphocytes, a complex of water-soluble antigens of the plague microbe was used. To identify the interdependence between the presence of protective anti-plague immunity and the level of CD 25+ expression intensity, the ED50 of the series under study was determined by the standard method.Results and discussion. A comparative analysis of the immunogenic activity of the live plague vaccine obtained on the experimental nutrient medium with the vaccine produced on Hottinger’s agar has been performed. When animals were immunized with doses of 4·103 , 2·104 and 1·105 live microbial cells (regulated doses), the highest level of expression of CD25 marker by lymphocytes was on the day 14, with a subsequent decrease on the day 21 after vaccination. When determining immunogenicity using the conventional method, a high degree of direct correlation between the number of surviving animals and an increase in the level of lymphocytes expressing markers of early activation has been established. Comparison has revealed the general pattern: when the lowest immunizing dose (8·102 ) was administered, activation of early immunity markers was not observed. In case of immunization with higher doses on days 7, 14 and 21, a proportional increase in the number of CD25-positive lymphocytes after stimulation with a specific antigen under in vitro conditions is detected in the blood of biomodels.
Giardia lamblia Reactive Arthritis Mimicking Acute Periprosthetic Knee Infection
Authors: Turner Rachael A. , Duke Justin N. , Foran Jared R.H. 
Published: July 2021

Case:
A healthy 49-year-old man with a well-functioning total knee replacement developed a painful swollen knee. The erythrocyte sedimentation rate was 12 mm/hour, and C-reactive protein was 20.3 mg/L. Aspiration revealed 24,440 white blood cells and 5% neutrophils. His 2018 International Consensus Meeting (ICM) definition score of 5 met criteria for “possibly infected.” He was diagnosed with reactive arthritis (ReA) secondary to Giardia lamblia, mimicking acute periprosthetic infection. He was successfully treated with a 10-week course of multiple oral antiparasitic medications.

Conclusion:
Systemic parasitic infectious ReA can mimic acute infection in the presence of total knee arthroplasty. Careful application of the 2018 ICM criteria can be critical for workup and the treatment of suspected periprosthetic infection.
Analysis of clinical characteristics, radiological predictors, pathological features and perioperative outcomes associated with perinephric fat adhesion degree
Authors: Liu Junqiang , Huang Hongwei , Cao Tianyu , Liu Dikuan , Zhu Zheng , Chen Jing , Wang Lina , Zong Huafeng , Song Xishuang , Wang Xuejian , Zhu Xinqing , Chen Qiwei , Nahayo Sony , Wang Jianbo , Yang Deyong 
Published: July 2021

Abstract
Background
To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes.
Methods
84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analysis were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data was compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels.
Results
20, 28, 18 and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF) and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender (p < 0.001), age (p = 0.003) and hypertension (p = 0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding (p = 0.001), posterior perinephric fat thickness (p = 0.009) and perinephric fat density (p = 0.02). APF was associated with drain output (P = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels.
Conclusions
Clinical characteristics and radiological predictors can evaluate PFAD and may assist guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.
GaInP/GaAs three-terminal heterojunction bipolar transistor solar cell
Authors: Zehender Marius , Svatek Simon , Steiner Myles , Garcia Ivan , Garcia-Linares Pablo , Warren Emily , Tamboli Adele , Martí Antonio , Antolín Elisa 
Published: July 2021

Abstract
We demonstrate a heterojunction bipolar transistor solar cell (HBTSC), a device that exhibits the performance of a double-junction solar cell in a more compact npn (or pnp) semiconductor structure. The HBTSC concept has the advantages of being a three-terminal device, such as low spectral sensitivity and high tolerance to non-optimal band-gap energies, while it has a lower fabrication and operation complexity than other multi-terminal architectures: it can produce independent power extraction from the two junctions without the need for extra isolating or interconnecting layers between them. The two junctions in our proof-of-concept HBTSC prototype, which is made of epitaxial GaInP/GaAs, exhibit independent current-voltage characteristics under AM1.5G illumination, with respective open-circuit voltages of 1.33 and 0.95 V. The HBTSC opens a new perspective in the understanding of multi-junction devices, and it is an excellent candidate for the application of low-cost fabrication techniques, and for the implementation of III-V-on-silicon tandems.
NPBS database: a chemical data resource with relational data between natural products and biological sources
Authors: Xu Tingjun , Chen Weiming , Zhou Junhong , Dai Jingfang , Li Yingyong , Zhao Yingli 
Published: July 2021

Abstract
NPBS (Natural Products & Biological Sources) database is a chemical data resource with relational data between natural products and biological sources, manually curated from literatures of natural product research. The relational data links a specific species and all the natural products derived from it, contrarily, links a specific natural product and all the biological sources. The biological sources cover diverse species of plant, bacterial, fungal and marine organism, the natural molecules have proper chemical structure data and computable molecular properties, and all the relational data have corresponding references. NPBS database provides a wider choice of biological sources, and can be used for dereplication to prevent re-isolation and re-characterization of already known natural products.