bluuebunny/crossref_metadata_2025_split huggingface dataset:
“If I’ve got latent TB, I would like to get rid of it”: Derivation of the CARD (Constraints, Actions, Risks, and Desires) Framework informed by South African healthcare worker perspectives on latent tuberculosis treatment
Authors: Nathavitharana Ruvandhi R. , van der Westhuizen Ananja , van der Westhuizen Helene-Mari , Mishra Hridesh , Sampson Annalean , Meintjes Jack , Nardell Edward , McDowell Andrew , Theron Grant 
Published: August 2021

Background
Healthcare workers (HWs) have at least twice the risk of tuberculosis (TB) compared to the general population. There is growing emphasis on latent TB infection (LTBI) in high-risk populations. Yet we know little about HWs’ perspectives of LTBI testing and treatment to inform implementation in high-incidence settings. We developed a qualitative networked approach to analyze HWs’ perspectives on LTBI testing and treatment.

Methods
We conducted 22 in-depth interviews with nurse and physician stakeholders, who had been recruited as part of a larger study evaluating TB transmission risk in HWs at Tygerberg Hospital, Cape Town, South Africa. We performed open coding to identify emergent themes and selective coding to identify relevant text citations. We used thematic analysis to inductively derive the CARD (Constraints, Actions, Risks, Desires) framework.

Results
All HWs desired to avoid developing TB but few felt this was actionable. Despite LTBI knowledge gaps, safety and cost concerns, most HWs reported hypothetical willingness to take LTBI treatment. The CARD framework showed that desire and action related to LTBI testing and treatment was clearly framed by the interactions between constraints, administrative action, and risk. The surprise HWs described on receiving a negative LTBI (Quantiferon-Plus) result suggests LTBI testing may recalibrate HWs’ perceptions regarding the futility of actions to reduce their TB risk.

Conclusions
LTBI testing and treatment are acceptable to HWs and could counteract the perceived inevitability of occupational TB infection that currently may limit risk reduction action. This should be coupled with administrative leadership and infrastructural support. The CARD analytic framework is a helpful tool for implementation scientists to understand current practices within complex health systems. Application of CARD could facilitate the development of contextually-relevant interventions to address important public health problems such as occupational TB.
Enlarged extracellular vesicles are a negative prognostic factor in patients undergoing TACE for primary or secondary liver cancer–a case series
Authors: Schöler David , Castoldi Mirco , Jördens Markus S. , Schulze-Hagen Max , Kuhl Christiane , Keitel Verena , Luedde Tom , Roderburg Christoph , Loosen Sven H. 
Published: August 2021

Background
Transarterial chemoembolization (TACE) has evolved as a standard treatment option in patients with intermediate stage, unresectable HCC [Barcelona Clinic Liver Cancer (BCLC) stage B] as well as in patients with liver metastases, when surgery or systemic therapy is considered not appropriate. Concentration and sizes of extracellular vesicles (EVs) recently emerged as novel diagnostic and prognostic biomarkers in patients with liver cancer, but no data on its prognostic relevance in the context of TACE exists. Here, we evaluate pre-interventional EVs as a potential biomarker in patients undergoing TACE for primary and secondary hepatic malignancies.

Methods
Vesicle size distribution and concentration were measured by nanoparticle tracking analysis (NTA) in patient sera before and after TACE in 38 patients.

Results
Extracellular vesicle size distribution measured before TACE is of prognostic significance with respect to overall survival in patients after TACE. Overall survival is significantly reduced when initial vesicle size (X50) is in the upper quartile (>145.65nm). Median overall survival in patients in the upper quartile was only 314 days, compared to 799 days in patients with vesicle size in the first to third quartile (<145.65nm; p = 0.007). Vesicle size was also shown to be a significant prognostic marker for overall survival in Cox regression analysis [HR 1.089, 95% CI: 1.021–1.162, p = 0.010]. In addition, a significant correlation was observed between initial EVs concentration/BMI (rS = 0.358, p = 0.029), X50/IL-8-concentration (rS = 0.409, p = 0.011) and X50/CRP-concentration (rS = 0.404, p = 0.016). In contrast, with regard to immediate tumor response after TACE, EVs concentration and size did not differ.

Summary
Sizes (but not concentrations) of EVs represent a novel prognostic marker in patients receiving TACE for primary and secondary hepatic malignancies since patients with enlarged EVs display a significantly impaired prognosis after TACE.
One-year outcome and survival analysis of deferred ventricular septal repair in cardiogenic shock supported with mechanical circulatory support
Authors: Malik Jahanzeb , Younus Faizan , Malik Asmara , Farooq Muhammad Umar , Kamal Ahmed , Shoaib Muhammad , Naeem Hesham , Rana Ghazanfar , Rana Abdul Sattar , Usman Muhammad , Khalil Shahid 
Published: August 2021

Background and objective
The effectiveness of deferred surgical repair of ventricular septal rupture (VSR) post-myocardial infarction (MI) with cardiogenic shock remains limited to case reports. Our study aimed to investigate the outcomes and survival analysis following mechanical circulatory support (MCS) in patients after VSR who develop cardiogenic shock.

Methods
We analyzed 27 patients with post-MI VSR and cardiogenic shock who received deferred surgical repair while stabilized on MCS between January 2018 and March 2020. After normality test adjustments, continuous variables were expressed as mean ± standard deviation (SD). These were compared using the Mann-Whitney U test and Student’s t-test. Categorical variables were compared using chi-square or Fisher’s exact test. To identify predictors of operative mortality, univariate analysis of clinical characteristics and interventions followed by logistic regression was carried out. P-value of < 0.05 was considered significant.

Results
All patients had preoperative MCS. Emergency repair was avoided in all the patients. The mean age of the participants was 64.96 with the majority being males (74.1%). On average, the mean time from MI to VSR repair was 18.85 days. Delayed revascularization was associated with increased mortality (OR 17.500, 95% CI 2.365–129.506, P = 0.005). Other factors associated with increased mortality were ejection fraction (EF), three-vessel disease, Killip class, early surgery, and prolonged use of inotropes. The operative mortality was 11% with an overall mortality of 33.3%. The one-year survival rate was 66.7%.

Conclusion
The use of MCS in adjunct to a deferred surgical approach shows an improved survival outcome of patients with VSR complicated by cardiogenic shock. Further investigations are required regarding the optimal time for MCS and surgical repair.
The closure of the Vardar ocean (the western domain of the northern Neotethys) from early Middle Jurassic to Paleocene time, based on surface geology of eastern Pelagonia and the Vardar zone, biostratigraphy, and seismic-tomographic images of the mantle below the Central Hellenides
Authors: Scherreiks Rudolph , Boudagher-Fadel Marcelle 
Published: August 2021

Seismic tomographic images of the mantle below the Hellenides indicate that the Vardar ocean probably had a composite width of over 3000 kilometres. From surface geology we know that this ocean was initially located between two passive margins: Pelagonian Adria in the west and Serbo-Macedonian-Eurasia in the east. Pelagonia was covered by a carbonate platform that accumulated, during Late Triassic to Early Cretaceous time, where highly diversified carbonate sedimentary environments evolved and reacted to the adjacent, converging Vardar ocean plate. We conceive that on the east side of the Vardar ocean, a Cretaceous carbonate platform evolved from Aptian to Maastrichtian time in the forearc basin of the Vardar supra-subduction volcanic arc complex.
The closure of the Vardar ocean occurred in one episode of ophiolite obduction and in two episodes of intra-oceanic subduction.
Association of SNP g.232 G>T Calpain Gene with Growth and Live Meat Quality Prediction using Ultrasound Images in Bali Cattle
Authors: Dairoh Dairoh , Jakaria Jakaria , Ulum Mokhamad Fakhrul , Ishak Andi Baso Lompengeng , Sumantri Cece 
Published: August 2021

Bali cattle (<em>Bos javanicus</em>) are native Indonesian cattle, domesticated from banteng (<em>Bibos banteng</em>). Genes that have an important role in meat quality are calcium-activated neutral protease genes, known as calpains (CAPN). The objective of this study was to evaluate the polymophisms of calpain gene SNP g.232 G&gt;T by PCR-RFLP technique and its influence on growth trait and meat quality of Bali cattle detected by ultrasound imaging of <em>longissimus dorsi</em> thickness (LDT), back fat thickness (BFT), marbling score (MS), and intramuscular fat percentage (PIMF). The polymorphisms of CAPN1 gene were analyzed by PCR-RFLP using BglII restriction enzyme (n=52 cattle). The ultrasound images of longissimus dorsi muscle were carried out transversally and longitudinal between 12<sup>th</sup> -13<sup>th </sup>thoracic vertebrae then analyzed by Image-J NIH software. Result showed that SNP g.232 G&gt;T of CAPN1 gene was polymorphic in Bali cattle. SNP g.232 G&gt;T of CAPN1 gene in Bali cattle has higher diversity which was showed of 0.48 heterozygosity value and was in Hardy-Weinberg equilibrium. The polymorphisms of SNP g.232 G&gt;T was associated significantly (P&lt;0.05) with bodyweight at 730 days, marbling score (MS), and intramuscular fat percentage (PIMF). It suggests that the CAPN1 gene in Bali cattle is a candidate for Marker Assisted Selection (MAS), which influences body weight at 730 days, marbling score, and percentage of intramuscular fat.
Monitoring the M-protein of multiple myeloma patients treated with a combination of monoclonal antibodies: the laboratory solution to eliminate interference
Authors: Noori Somayya , Verkleij Christie P. M. , Zajec Marina , Langerhorst Pieter , Bosman Patricia W. C. , de Rijke Yolanda B. , Zweegman Sonja , VanDuijn Martijn , Luider Theo , van de Donk Niels W. C. J. , Jacobs Joannes F. M. 
Published: August 2021

Abstract

Objectives
The therapeutic monoclonal antibody (t-mAb) daratumumab, used to treat multiple myeloma (MM) patients, interferes with routine, electrophoretic based M-protein diagnostics. Electrophoretic response assessment becomes increasingly difficult when multiple t-mAbs are combined for use in a single patient. This is the first study to address the analytical challenges of M-protein monitoring when multiple t-mAbs are combined.

Methods
In this proof-of-principle study we evaluate two different methods to monitor M-protein responses in three MM patients, who receive both daratumumab and nivolumab. The double hydrashift assay aims to resolve t-mAb interference on immunofixation. The MS-MRD (mass spectrometry minimal residual disease) assay measures clonotypic peptides to quantitate both M-protein and t-mAb concentrations.

Results
After exposure to daratumumab and nivolumab, both t-mAbs become visible on immunofixation electrophoresis (IFE) as two IgG-kappa bands that migrate close to each other at the cathodal end of the γ-region. In case the M-protein co-migrates with these t-mAbs, the observed interference was completely abolished with the double IFE hydrashift assay. In all three patients the MS-MRD assay was also able to distinguish the M-protein from the t-mAbs. Additional advantage of the MS-MRD assay is that this multiplex assay is more sensitive and allows quantitative M-protein-, daratumumab- and nivolumab-monitoring.

Conclusions
Daratumumab and nivolumab interfere with electrophoretic M-protein diagnostics. However, the M-protein can be distinguished from both t-mAbs by use of a double hydrashift assay. The MS-MRD assay provides an alternative method that allows sensitive and simultaneous quantitative monitoring of both the M-protein and t-mAbs.
Comparison of corrosion behavior of 2205 and 2507 duplex stainless steel in simulated flue gas condensate of a waste incineration power plant
Authors: Ge Fang , Wang Xiaojie , Meng Xinjing , Huang Xin , Zhang Yi , Song Yanfang , Ge Honghua , Zhao Yuzeng 
Published: August 2021

Abstract
The corrosion behavior of duplex stainless steel 2205 DSS and 2507 DSS in simulated flue gas condensate of a waste incineration power plant at 180 °C was compared by micro-area electrochemical testing, surface and weight loss analysis. The results showed that the corrosion resistance of the two stainless steels decreased with the increase of Cl− concentration. After 48 h of corrosion, when the Cl− concentration was not less than 6 g·L−1, active sites where current density increased suddenly appeared on the surface of 2205 DSS, accompanied by the obvious increase of surface roughness and the weight loss. The lowest Cl− concentration that caused the appearance of active sites on the surface of 2507 DSS was 20 g·L−1, with less surface corrosion products and lower degree of general corrosion.
On a Chomskyan postulation in conceptual metaphor theory
Authors: Jiang Yicun 
Published: August 2021

Abstract
This paper is an attempt to make a comparison between Lakoff and Johnson’s conceptual metaphor theory and Chomsky’s transformational generative grammar, and to demonstrate a Chomskyan postulation in the former. Although Lakoff and Johnson regard Chomsky’s linguistics as a modern representative of traditional Western philosophies of language that tend to highlight the a priori assumptions rather than empirical findings, the cognitive theory of metaphor contains a Chomskyan metaphysical assumption as its most important notion, i.e. the assumption of conceptual metaphors. Thus, what the present paper wants to argue with ample evidence is that Lakoff and Johnson’s conceptual metaphor theory resembles Chomsky’s logic and that their notion of conceptual metaphors is very much a Chomskyan postulation. What the present study tries to further demonstrate is that the abovementioned two theories actually have many points in common, which also implies that Lakoff and Johnson have failed to avoid the paradigm that they believe is conflicting with their own.
Constructing online tourist destination images: a visual discourse analysis of the official Beijing Tourism website
Authors: Qi Wenjin , Sorokina Nadezda 
Published: August 2021

Abstract
Having the right image as a tourist destination brings immense benefits for a city’s international recognition in an increasingly competitive tourist industry. Official tourism websites as effective platforms to project a destination image online are able to provide substantial information about the tourist destination and attract a wider potential for inbound tourists from a global market. However, a lack of sufficient research has been noted regarding the integration of tourism studies and the study of website discourse, particularly visual discourse. This study, drawing on the theory of metafunctions in semiotics, conducts a visual discourse analysis by examining the three metafunctional meanings of visual images extracted from the official Beijing Tourism website. The results of both quantitative and qualitative analyses showed that the investigated website constructs an online city destination image through a multiplicity of tourist resources. The study concludes by outlining the practical benefits for tourism website designers and implications for future research.
The social semiotic context of the fashion show
Authors: Günay V. Doğan 
Published: August 2021

Abstract
A fashion show is a form of social activity which is worth examining on several counts, including in terms of the preparation of garments, the space in which they are presented, and the way of presenting them. In this study, the fashion show is evaluated within the boundaries of social semiotics, which is widely accepted as a subfield of semiotics. Single garments are not presented in the show. Instead, a collection of garments created by a fashion designer in the context of a particular theme and style is presented. The collection made by the designer also forms the discourse of the designer. There are fashion models who present the collection of garments in front of clients. Although the models are on the podium, they are, in fact, in the position of the voice of the fashion designer. It is the models who present the elements of discourse on the podium to the recipients. Accordingly, this paper first scrutinizes the theory of social semiotics. In this context, the place of the subject, object, and the discourse are examined. Then the obtained data is used for the analysis of situations in the show.
Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release
Authors: Spiller Sabrina , Clauder Franziska , Bellmann-Sickert Kathrin , Beck-Sickinger Annette G. 
Published: August 2021

Abstract
Implant design has evolved from biochemically inert substrates, minimizing cell and protein interaction, towards sophisticated bioactive substrates, modulating the host response and supporting the regeneration of the injured tissue. Important aspects to consider are the control of cell adhesion, the discrimination of bacteria and non-local cells from the desired tissue cell type, and the stimulation of implant integration and wound healing. Here, the extracellular matrix acts as a role model providing us with inspiration for sophisticated designs. Within this scope, small bioactive peptides have proven to be miscellaneously deployable for the mediation of surface, cell and matrix interactions. Combinations of adhesion ligands, proteoglycans, and modulatory proteins should guide multiple aspects of the regeneration process and cooperativity between the different extracellular matrix components, which bears the chance to maximize the therapeutic efficiency and simultaneously lower the doses. Hence, efforts to include multiple of these factors in biomaterial design are well worth. In the following, multifunctional implant coatings based on bioactive peptides are reviewed and concepts to implement strong surface anchoring for stable cell adhesion and a dynamic delivery of modulator proteins are discussed.
The strategy developed for high conversion and the multiplicity problems of biochemical reaction in a real CSTR with Cholette’s model
Authors: Yang Chane-Yuan , Tsai Ding-Chi , Chien Yu-Shu 
Published: August 2021

Abstract
In this paper we used the examples for four kinetic schemes under substrate and product inhibition of a biochemical reaction occurring in a real CSTR with Cholette’s model to demonstrate the strategy for high conversion and the multiplicity problem. In addition, it is found that the non-ideal mixing indeed influences the necessary and sufficient conditions for input multiplicity and output multiplicity. Meanwhile, for each of four kinetic schemes under substrate and product inhibition of a biochemical reaction, the input multiplicity regions are found inside the output multiplicity regions. This fact reveals that when deriving an operating strategy to obtain a high conversion and to avoid the control problem, only the output multiplicity is needed to consider even in the CSTR with the input and output multiplicity occurring simultaneously.
Access and reach of linguistic repertoires in periods of change: a theoretical approach to sociolinguistic inequalities
Authors: Weirich Anna-Christine 
Published: August 2021

Abstract
The two notions of scope and access connect an understanding of societal multilingualism in a socio-economic context (linguistic relations) with the analysis of individual multilingualism (linguistic repertoires and linguistic practice). These notions produce a theoretical framework for discussing sociolinguistic inequalities that links the macro-level of social relations with the micro perspective of specific individuals and practices. Linguistic relations are dynamic and can undergo abrupt changes that urge multilingual speakers to restructure their linguistic repertoires to adapt to altered linguistic relations. With the help of the concepts of access and scope, we can describe which social functions specific linguistic resources have (scope) and how speakers are positioned to acquire these resources (access). This describes the relation of speakers to their linguistic resources as currently (un)available (scope) and potentially (un)learnable (access), depending on the social context in which they are practiced. Using these notions as a theoretical framework, this text discusses two scenarios of change connected to mobility and immobility illustrated with examples from research in the Republic of Moldova. The first case is one of ruptured sociolinguistic relations because of drastic changes in a state’s language policies with which immobile speakers are confronted. A highly qualified Moldovan labor migrant in Italy serves as an example of mobility.
Phraseological complexity and low- and intermediate-level L2 learners’ writing quality
Authors: Jiang Jingyang , Bi Peng , Xie Nana , Liu Haitao 
Published: August 2021

AbstractThis study explores the extent to which phraseological complexity measures can predict second-language (L2) writing quality of low- and intermediate-level learners, especially in comparison with the more traditional syntactic and lexical complexity measures. To measure phraseological complexity, we evaluated phraseological diversity and phraseological sophistication by focusing on two commonly-used phraseological units (adjective-noun and verb-direct-object combinations). Our findings show that phraseological, syntactic, and lexical complexity measures can respectively explain 36.0, 34.4, and 56.5% of variance in writing scores. Although lexical complexity measures are responsible for more variance in writing scores, all three complexity dimensions contribute to the predictive power of writing scores, as evinced by the combined model explaining 63.4% of variance. Most phraseological complexity measures were loaded onto individual factors by the factor analysis, suggesting that phraseological complexity is an independent dimension of L2 complexity.
Optimizing pediatric histrelin implantation to improve success rates in clinic without sedation
Authors: Krishna Vikram , Lee Steven L. , DeUgarte Daniel A. 
Published: August 2021

Abstract

Objectives
The purpose of this study was to review our success rate performing the histrelin implant procedure in clinic without sedation.

Methods
A retrospective study was performed for histrelin implant procedures done at our institution from 2008 to 2020. Wilcoxon rank-sum test or Fisher’s exact test was utilized to identify significant differences (p<0.05).

Results
A total of 73 patients underwent 184 histrelin implant procedures from 2008 to 2020. In the past few years, there has been a decrease in procedures for precocious puberty and an increase for gender dysphoria. The majority of procedures were performed in clinic without sedation (82%). The only risk factor associated with requiring sedation was younger age (median 9 vs. 10 years; p<0.003). Complications (i.e. implant fracture or need for counter-incision) were noted in 10 of the procedures (5%). The only risk factor identified for a procedural complication during implant removal/replacement was interval time from insertion (21 vs. 13 months; p<0.01). The only documented wound problem reported was dermatitis in 1 patient (no suture granuloma, dehiscence, or implant extravasation).

Conclusions
Procedural refinements and distraction therapy have enabled us to perform the majority of procedures in clinic without sedation. In our experience, procedural difficulty and complications appear to increase with prolonged implant duration. Histrelin implantation is increasingly being performed for gender dysphoria.