bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards general scalar-Yukawa renormalisation group equations at three-loop order
Authors: Steudtner Tom 
Published: May 2021

AbstractFor arbitrary four-dimensional quantum field theories with scalars and fermions, renormalisation group equations in the$$ \overline{\mathrm{MS}} $$MS¯scheme are investigated at three-loop order in perturbation theory. Collecting literature results, general expressions are obtained for field anomalous dimensions, Yukawa interactions, as well as fermion masses. The renormalisation group evolution of scalar quartic, cubic and mass terms is determined up to a few unknown coefficients. The combined results are applied to compute the renormalisation group evolution of the gaugeless Litim-Sannino model.
Paternal outcrossing success differs among faba bean genotypes and impacts breeding of synthetic cultivars
Authors: Brünjes Lisa , Link Wolfgang 
Published: May 2021

Abstract
Key message
Faba bean genotypes showed significant and marked genetic differences in their success as pollen donors to cross-fertilized seeds. The findings may improve exploitation of heterosis in synthetic cultivars.

Abstract
In partially allogamous crops such as faba bean (Vicia faba L.), increasing the share of heterosis in a synthetic cultivar can improve yield and yield stability. The share of heterosis in such synthetic cultivars is increased by higher degrees of cross-fertilization. This trait is defined as percentage of cross-fertilized seeds among all seeds and is a crucial parameter in breeders’ yield predictions. Current approaches use degree of cross-fertilization to predict inbreeding and share of heterosis, they even consider genotype-specific degrees; yet, all genotypes are assumed to contribute equally to the cross-fertilized seeds. Here, we expect faba bean genotypes to differ in their success rates as pollen donors, i.e. in paternal outcrossing success. To quantify the variation of both, the degree of cross-fertilization and the paternal outcrossing success, we assessed these parameters in inbred lines and F1 hybrids, grown in four polycrosses composed of eight genotypes each. We identified the paternal genotype of 500 to 800 seeds per genotype and polycross using SNP markers. In both traits, we found marked and significant variation among inbred lines and among F1 hybrids, as well as between inbred lines and F1. Based on our findings, we discuss how differential paternal outcrossing success influences the amount of inbreeding in synthetic cultivars. Our findings offer the potential for a better management and exploitation of heterotic yield increase in faba bean.
Estimating the cumulative risk of postnatal depressive symptoms: the role of insomnia symptoms across pregnancy
Authors: Pietikäinen Johanna T. , Härkänen Tommi , Polo-Kantola Päivi , Karlsson Hasse , Paunio Tiina , Karlsson Linnea , Paavonen E. Juulia 
Published: May 2021

Abstract
Purpose
Insomnia symptoms during late pregnancy are a known risk for postnatal depressive symptoms (PDS). However, the cumulative effect of various risk factors throughout pregnancy has not been explored. Our aim was to test how various insomnia symptoms (sleep latency, duration, quality, frequent night awakenings, early morning awakenings) and other risk factors (e.g., history of depression, symptoms of depression and anxiety, as well as sociodemographic factors) in early, mid-, and late pregnancy predict PDS.

Methods
Using data from the FinnBrain Birth Cohort Study and logistic regression analyses, we investigated the associations of distinct insomnia symptoms at gw 14, 24, and 34 with depressive symptoms (Edinburgh Postnatal Depression Scale score ≥ 11) 3 months postnatally. We also calculated separate and combined predictive models of PDS for each pregnancy time point and reported the odds ratios for each risk group.

Results
Of the 2224 women included in the study, 7.1% scored EPDS ≥ 11 3 months postnatally. Our predictive models indicated that sleep latency of ≥ 20 min, anxiety in early pregnancy, and insufficient sleep during late pregnancy predicted the risk of PDS. Furthermore, we found highly elevated odds ratios in early, mid-, and late pregnancy for women with multiple PDS risk factors.

Conclusion
Screening of long sleep latency and anxiety during early pregnancy, in addition to depression screening, could be advisable. Odds ratios of risk factor combinations demonstrate the magnitude of cumulating risk of PDS when multiple risk factors are present.
First-time anterior cruciate ligament injury in adolescent female elite athletes: a prospective cohort study to identify modifiable risk factors
Authors: Zebis M. K. , Aagaard P. , Andersen L. L. , Hölmich P. , Clausen M. B. , Brandt M. , Husted R. S. , Lauridsen H. B. , Curtis D. J. , Bencke J. 
Published: May 2021

Abstract
Purpose
To identify modifiable biomechanical and neuromuscular anterior cruciate ligament (ACL) injury risk factors for first-time ACL injury in adolescent female elite football and team handball players.

Methods
Adolescent female elite football and handball players with no previous ACL injury participated in the present study. At baseline, players were tested during side-cutting manoeuvres performed in a 3-dimensional motion analysis laboratory with concomitant electromyography (EMG) measurements. Maximal isometric lower limb muscle strength was assessed by handheld dynamometry. Players were prospectively followed for 2 years after baseline testing, and all magnetic resonance imaging (MRI) verified ACL injuries were registered. The effect of 16 risk factor candidates on the relative risk (RR) of ACL injury was estimated using Poisson regression analysis.

Results
Ninety players (age 16.9 ± 1.2 years) were included in the analyses. Nine first-time ACL injuries (injury incidence 10.0% (95% confidence interval (CI) 5.4–18.6%)) were registered during the 2-year follow-up period. Four risk factor candidates were significantly associated with the risk of ACL injury: (1) hip flexion angle at initial contact (IC) [RR 0.56, 95% confidence interval (CI) 0.34–0.92], (2) internal knee rotation angle at IC [RR 1.13, 95% CI 1.08–1.19], (3) semitendinosus EMG activity 50 ms prior to IC [RR: 0.62, 95% CI 0.43–0.89], and (4) external hip rotator strength [RR: 0.77, 95% CI 0.66–0.89].

Conclusion
Four distinct ACL injury risk factors related to the side-cutting manoeuvre were identified in a population of adolescent female elite football and team handball players with no previous ACL injury. As ACL injury typically occur during side-cutting, intervention programmes to modify these risk factors pose a promising strategy for ACL injury prevention in adolescent female elite football and team handball.

Level of evidence
II.
Electric properties of olive oil under pressure
Authors: Pawlicki L. T. , Siegoczyński R. M. , Ptasznik S. , Marszałek K. 
Published: May 2021

AbstractThe main purpose of the experiment was a thermodynamic research with use of the electric methods chosen. The substance examined was olive oil. The paper presents the resistance, capacitive reactance, relative permittivity and resistivity of olive. Compression was applied with two mean velocities up to 450 MPa. The results were shown as functions of pressure and time and depicted on the impedance phase diagram. The three first order phase transitions have been detected. All the changes in material parameters were observed during phase transitions. The material parameters measured turned out to be the much more sensitive long-time phase transition factors than temperature. The values of material parameters and their dependence on pressure and time were compared with the molecular structure, arrangement of molecules and interactions between them. Knowledge about olive oil parameters change with pressure and its phase transitions is very important for olive oil production and conservation.
Compatibility Complex for Black Hole Spacetimes
Authors: Aksteiner Steffen , Andersson Lars , Bäckdahl Thomas , Khavkine Igor , Whiting Bernard 
Published: May 2021

AbstractThe set of local gauge invariant quantities for linearized gravity on the Kerr spacetime presented by two of the authors (Aksteiner and Bäckdahl in Phys Rev Lett 121:051104, 2018) is shown to be complete. In particular, any gauge invariant quantity for linearized gravity on Kerr that is local and of finite order in derivatives can be expressed in terms of these gauge invariants and derivatives thereof. The proof is carried out by constructing a complete compatibility complex for the Killing operator, and demonstrating the equivalence of the gauge invariants from Aksteiner and Bäckdahl (Phys Rev Lett 121:051104, 2018) with the first compatibility operator from that complex.
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain–based vaccine candidate, RBD219-N1C1
Authors: Lee Jungsoon , Liu Zhuyun , Chen Wen-Hsiang , Wei Junfei , Kundu Rakhi , Adhikari Rakesh , Rivera Joanne Altieri , Gillespie Portia M. , Strych Ulrich , Zhan Bin , Hotez Peter J. , Bottazzi Maria Elena 
Published: May 2021

Abstract
A SARS-CoV-2 RBD219-N1C1 (RBD219-N1C1) recombinant protein antigen formulated on Alhydrogel® has recently been shown to elicit a robust neutralizing antibody response against SARS-CoV-2 pseudovirus in mice. The antigen has been produced under current good manufacturing practices (cGMPs) and is now in clinical testing. Here, we report on process development and scale-up optimization for upstream fermentation and downstream purification of the antigen. This includes production at the 1-L and 5-L scales in the yeast, Pichia pastoris, and the comparison of three different chromatographic purification methods. This culminated in the selection of a process to produce RBD219-N1C1 with a yield of >400 mg per liter of fermentation with >92% purity and >39% target product recovery after purification. In addition, we show the results from analytical studies, including SEC-HPLC, DLS, and an ACE2 receptor binding assay that were performed to characterize the purified proteins to select the best purification process. Finally, we propose an optimized upstream fermentation and downstream purification process that generates quality RBD219-N1C1 protein antigen and is fully scalable at a low cost.

Key points
• Yeast fermentation conditions for a recombinant COVID-19 vaccine were determined.
• Three purification protocols for a COVID-19 vaccine antigen were compared.
• Reproducibility of a scalable, low-cost process for a COVID-19 vaccine was shown.
Graphical abstract
Radiomics and gene expression profile to characterise the disease and predict outcome in patients with lung cancer
Authors: Kirienko Margarita , Sollini Martina , Corbetta Marinella , Voulaz Emanuele , Gozzi Noemi , Interlenghi Matteo , Gallivanone Francesca , Castiglioni Isabella , Asselta Rosanna , Duga Stefano , Soldà Giulia , Chiti Arturo 
Published: May 2021

Abstract
Objective
The objectives of our study were to assess the association of radiomic and genomic data with histology and patient outcome in non-small cell lung cancer (NSCLC).

Methods
In this retrospective single-centre observational study, we selected 151 surgically treated patients with adenocarcinoma or squamous cell carcinoma who performed baseline [18F] FDG PET/CT. A subgroup of patients with cancer tissue samples at the Institutional Biobank (n = 74/151) was included in the genomic analysis. Features were extracted from both PET and CT images using an in-house tool. The genomic analysis included detection of genetic variants, fusion transcripts, and gene expression. Generalised linear model (GLM) and machine learning (ML) algorithms were used to predict histology and tumour recurrence.

Results
Standardised uptake value (SUV) and kurtosis (among the PET and CT radiomic features, respectively), and the expression of TP63, EPHA10, FBN2, and IL1RAP were associated with the histotype. No correlation was found between radiomic features/genomic data and relapse using GLM. The ML approach identified several radiomic/genomic rules to predict the histotype successfully. The ML approach showed a modest ability of PET radiomic features to predict relapse, while it identified a robust gene expression signature able to predict patient relapse correctly. The best-performing ML radiogenomic rule predicting the outcome resulted in an area under the curve (AUC) of 0.87.

Conclusions
Radiogenomic data may provide clinically relevant information in NSCLC patients regarding the histotype, aggressiveness, and progression. Gene expression analysis showed potential new biomarkers and targets valuable for patient management and treatment. The application of ML allows to increase the efficacy of radiogenomic analysis and provides novel insights into cancer biology.
CAS FGOALS-f3-L Large-ensemble Simulations for the CMIP6 Polar Amplification Model Intercomparison Project
Authors: He Bian , Zhang Xiaoqi , Duan Anmin , Bao Qing , Liu Yimin , Hu Wenting , Li Jinxiao , Wu Guoxiong 
Published: May 2021

AbstractLarge-ensemble simulations of the atmosphere-only time-slice experiments for the Polar Amplification Model Intercomparison Project (PAMIP) were carried out by the model group of the Chinese Academy of Sciences (CAS) Flexible Global Ocean-Atmosphere-Land System (FGOALS-f3-L). Eight groups of experiments forced by different combinations of the sea surface temperature (SST) and sea ice concentration (SIC) for pre-industrial, present-day, and future conditions were performed and published. The time-lag method was used to generate the 100 ensemble members, with each member integrating from 1 April 2000 to 30 June 2001 and the first two months as the spin-up period. The basic model responses of the surface air temperature (SAT) and precipitation were documented. The results indicate that Arctic amplification is mainly caused by Arctic SIC forcing changes. The SAT responses to the Arctic SIC decrease alone show an obvious increase over high latitudes, which is similar to the results from the combined forcing of SST and SIC. However, the change in global precipitation is dominated by the changes in the global SST rather than SIC, partly because tropical precipitation is mainly driven by local SST changes. The uncertainty of the model responses was also investigated through the analysis of the large-ensemble members. The relative roles of SST and SIC, together with their combined influence on Arctic amplification, are also discussed. All of these model datasets will contribute to PAMIP multi-model analysis and improve the understanding of polar amplification.
Impact of bioprosthetic valve type on peri-procedural myocardial injury and mortality after transcatheter aortic valve replacement
Authors: De Marzo Vincenzo , Crimi Gabriele , Vercellino Matteo , Benenati Stefano , Pescetelli Fabio , Della Bona Roberta , Sarocchi Matteo , Canepa Marco , Balbi Manrico , Porto Italo 
Published: May 2021

AbstractPeri-procedural myocardial injury (PPMI) is a common complication after transcatheter valve replacement (TAVR), often remaining clinically silent. The role of valve type on PPMI and the association between PPMI and mortality are still unclear. We sought to evaluate predictors and outcome of PPMI after TAVR, and the impact of self-expandable valve (SEV) vs. balloon-expandable valve (BEV) deployment on PPMI. Consecutive patients who underwent successful TAVR in a single-center from January 2014 to December 2019 were included. PPMI was defined according to a modified Valve Academic Research Consortium (VARC)-2 definition as a post-procedure elevation of troponin (with a peak value ≥ 15-times the upper-reference limit) < 72 h after TAVR. We included 596 patients, of whom 258 (43.3%) were men. Mean age was 83.4 ± 5.5 years. We deployed 368 (61.7%) BEV and 228 (38.3%) SEV. PPMI was observed in 471 (79.0%) patients. At multivariable analysis, SEV (OR 2.70, 95% CI 1.64–4.55, p < 0.001), creatinine clearance (OR 0.98, 95% CI 0.97–1.00, p = 0.011), and baseline ejection fraction (OR 1.05, 95% CI 1.02–1.07, p < 0.001) were independent predictors of PPMI; these findings were also confirmed using a propensity-weighted analysis. Thirty-day and 1-year all-cause mortality rates were 2.5% and 8.1%, respectively. No associations between PPMI and 30-day (p = 0.488) or 1-year (p = 0.139) all-cause mortality were found. Independent predictors of 30-day mortality were increasing EUROSCORE II (HR 1.16 per score point, 95% CI 1.08–1.19, p < 0.001) and life-threatening/major bleeding complications (HR 5.87, 95% CI 1.28–26.58, p = 0.019), whereas EUROSCORE II (HR 1.08, 95% CI 1.04–1.13, p = 0.031) and acute kidney injury (HR 2.59, 95% CI 1.20–5.35, p = 0.020) were related to 1-year mortality. PPMI is frequent after TAVR, but it does not affect 30-day or 1-year all-cause mortality. SEV implantation is associated with an increased frequency of PPMI.
Dietary patterns associated with renal impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)
Authors: Paterson Euan N. , Neville Charlotte E. , Wallace Sara M. , Woodside Jayne V. , Kee Frank , Young Ian S. , Cruise Sharon , McGuinness Bernadette , Maxwell Alexander P. , McKay Gareth J. 
Published: May 2021

Abstract
Background
Dietary-based primary prevention guidelines for chronic kidney disease (CKD) treatment are lacking due to limited evidence. Single nutrient intake studies do not account for complex dietary interactions. We assessed associations between dietary patterns and renal function in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA).

Design
A cross-sectional observational study used NICOLA baseline dietary data collected between February 2014 and March 2016 via a food frequency questionnaire for 2590 participants aged ≥ 50 years. Principal component analysis identified a posteriori dietary patterns. Renal function was characterised by estimated glomerular filtration rate (eGFR) using serum creatinine and cystatin-C. Associations were assessed according to quintiles of dietary pattern adherence and multivariable regression analysis examined associations with eGFR.

Results
Variation in three dietary patterns was significantly associated with eGFR. After adjustment for potential confounders, participants with least adherence to the ‘healthy’ dietary pattern 1 had a mean eGFR 3.4 ml/min/1.73m2 (95% confidence interval, [CI] − 5.0, − 1.7, p < 0.001) lower than the most adherent. Those with lowest adherence to the ‘unhealthy’ dietary pattern 2 had a mean eGFR 1.9 ml/min/1.73m2 (CI 0.2, 3.5, p = 0.03) higher than those with highest adherence. Participants with lowest adherence to dietary pattern 3, characterised by a high consumption of alcohol and coffee, had a mean eGFR 1.8 ml/min/1.73m2 (− 3.5, − 0.01, p = 0.05) lower than those with greatest adherence.

Conclusions
Our findings identify independent associations between dietary patterns and eGFR. These findings can inform the development of diet-related primary prevention advice for CKD.
Differences in single positive formal thought disorder symptoms between closely matched acute patients with schizophrenia and mania
Authors: Kircher Tilo , Stein Frederike , Nagels Arne 
Published: May 2021

AbstractFormal thought disorders (FTD) are a hallmark diagnostic feature of schizophrenia (SZ) and (bipolar) mania (MA). FTD can be separated into positive (pFTD) and negative dimensions. It is unclear whether there are differences in pFTD on a single symptom level between acutely ill patients with SZ and MA, which cannot be attributed to cognitive impairment. We compared single pFTD symptoms in two groups of acutely ill patients with ICD-10 bipolar mania and schizophrenia, closely matched for age, sex, pFTD TALD score, verbal IQ and neuropsychological test performance (executive function, verbal fluency, attention, and working memory). SZ patients had higher severity of the TALD symptoms “perseverations” and “poverty of content of speech” than those with MA (Mann–Whitney U, significant, Bonferroni corrected). Speech in acute SZ patients differs from MA in that it conveys little information and adheres to previously mentioned ideas and topics. Matching for confounding variables, such as IQ and cognition, is important when comparing patients with different diagnoses.
Effects of age on psychosocial working conditions and future labour market marginalisation: a cohort study of 56,867 Swedish twins
Authors: Wang Mo , Svedberg Pia , Narusyte Jurgita , Farrants Kristin , Ropponen Annina 
Published: May 2021

Abstract
Purpose
Previous studies have reported an elevated risk of sickness absence (SA) and disability pension (DP) due to adverse psychosocial working conditions, yet the influence of age and familial factors on the associations have not been examined. We aimed to investigate associations between psychosocial working conditions and labour market marginalisation (LMM) in terms of unemployment, SA and DP adjusting for familial confounding and possible differences in these associations with different age groups and different unemployment and sick leave days.

Methods
All twins living in Sweden in 2001, aged 16–64 years and not on old-age pension or DP were included (n = 56,867). The twins were followed from 2002 to 2016 regarding unemployment, SA and DP. Cox proportional hazards regression models were performed for the whole sample, and for discordant twin pairs, in five age groups.

Results
Each one-unit increase in job demands and job control was associated with a lower risk of unemployment, SA and DP in all age groups. Moreover, each one-unit increase in social support was associated with an increased risk of 1–30 days unemployment in individuals older than 45 years and SA and DP. Social support decreased the risk of unemployment longer than 365 days in age groups 16–25 and 36–45 years. In the discordant twin pair analyses, the estimates attenuated towards statistical non-significance.

Conclusion
Even though familial factors seem to influence the associations between psychosocial working conditions and LMM, improving psychosocial working conditions by for example promoting high job control and social support at workplace may reduce the risk of future short- and long-term LMM in all age groups.