bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcatheter aortic valve replacement for structural degeneration of previously implanted transcatheter valves (TAVR-in-TAVR): a systematic review
Authors: Gallo Michele , Fovino Luca Nai , Blitzer David , Doulamis Ilias P , Guariento Alvise , Salvador Loris , Tagliari Ana Paula , Ferrari Enrico 
Published: October 2021

Abstract

OBJECTIVES
Transcatheter aortic valve replacement (TAVR) represents a valid treatment for patients with aortic valve stenosis and high or intermediate surgical risk. However, biological transcatheter valves can also experience a structural degeneration after years, and a redo-TAVR procedure (TAVR-in-TAVR) can be a valid option. We revised the current available literature for indications, procedural and technical details and outcome on TAVR-in-TAVR procedures for degenerated TAVR valves.

METHODS
A systematic search was conducted in the public medical database for scientific articles on TAVR-in-TAVR procedures for degenerated transcatheter valves. Data on demographics, indications, first and second transcatheter valve type and size, mortality, complications and follow-up were extracted and analysed.

RESULTS
A total of 13 studies (1 multicentre, 3 case series, 9 case reports) were included in this review, with a total amount of 160 patients treated with TAVR-in-TAVR procedures for transcatheter valve failure. The mean age was 74.8 ± 7.8 with 84 males (52.8%). The mean elapsed time from the first TAVR procedure was 58.1 ± 23.4 months. Main indication for TAVR-in-TAVR was pure stenosis (38.4%, with mean gradient of 44.5 ± 18.5 mmHg), regurgitation (31.4%), mixed stenosis and regurgitation (29.5%) and leaflet thrombosis (8.8%). Procedural success rate was 86.8%, with second TAVR valve malposition occurred in 4 cases (2.5%). The hospital mortality rate was 1.25% (2/160). Post-procedural echocardiographic control showed moderate regurgitation in 5.6% of patients (9/160) and residual transvalvular mean gradient ≥20 mmHg in 5% of cases. Postoperative complications included major vascular complications (8.7%), new pacemaker implantation (8.7%), acute kidney failure (3.7%), stroke (0.6%) and coronary obstruction (0.6%). The mean follow-up time was 6 ± 5.6 months with 1 non-cardiovascular death reported.

CONCLUSIONS
TAVR-in-TAVR represents a valid alternative to standard surgery for the treatment of degenerated transcatheter valves in high-risk patients. Despite these promising results, further studies are required to assess durability and haemodynamic performances of the second TAVR valve.
Clinical Characteristics, Laboratory Profiles, And Treatment Modalities for Familial Hypercholesterolemia in Egypt
Authors: Reda Ashraf , Bendary Ahmed , Elserafy Ahmed Shawky , Ashraf Mohamed , Dawood Ehab , Emil Sameh , Elbahry Atef , Sanad Osama , Bendary Mohamed , Elhadidy Amro , Rafla Samir , Tabl Mohamed Abdelshafy , Khamis Hazem , Kazamel Ghada , Kamal Seif , Naguib Tarek , Sobhy Mohamed 
Published: October 2021

Abstract

Aims
The aim of the Familial Hypercholesterolemia Research Collaboration (FHRC) is to collect date about the clinical, laboratory phenotypes, and treatment strategies of patients with FH all over the world. We present the Egyptian data of this international registry.

Methods and Results
An online electronic case report form (e-CRF) was prepared to collect data matching the protocol of the FHSC of the European Atherosclerosis Soci- ety (EAS). From August 2017 to March 2021, a total of 228 cases with FH (46% males, mean age 48 ± 14 years) were enrolled. About 71% of whom came from urban areas. The mean Body Mass Index (BMI) was 30 ± 4.9 kg/m2. The most commonly reported concomitant risk factor was hypertension (39%), followed by smoking (22%), and then DM (18%). Median time from diagnosis to enrolment was 7 (range 0.5-20) years. The vast majority (99.1%) were diagnosed based on the Dutch Lipid Clinic criteria, with 14%, 11% and 75% in the definite, probable, and possible categories respectively. Genetic test was performed in only 1 patient, in which the defect was heterozygous FH (defective ApoB). Mean baseline levels for total cholesterol was 316±86 mg/dl, median (ranges) for triglycerides was 190 (38-1400) mg/dl, for LDL-C was 237±77 mg/dl and for HDL-C was 47±14 mg/dl. Importantly, the mean Lp(a) was 42±12 mg/dl. All but one patient received lipid lowering therapy. Statins were prescribed in 226 out of 228 patients enrolled (99.1%). Statin prescriptions were equally distributed between Atorvastatin and Rosuvastatin (41% for each). Forty five percent received monotherapy and 56% received combination therapy (most commonly with Ezetimibe [55.7%], then with Fibrates [7.9%], then with proprotein con- vertase subtilisin/kexin type 9 (PCSK-9 inhibitors) [2.6%], and finally with Omega-3 fatty acids [0.9%]). Only one patient received lipoprotein apheresis.

Conclusion
The Egyptian part of the FHRC, to the best of our knowledge, is the first FH registry in Egypt. Our data show that the e-CRF system is feasible and reliable. The phenotype of enrolled FH cases showed higher female preponderance, very high lipoprotein levels, and unfortunately inadequate therapeutic interventions (with un- derutilization of PCSK-9 inhibitors). This is a call to action in order to mitigate these management gaps for this high-risk group.
A Multi-Agent Platform to Explore Strategies for Age-Friendly Community Projects in Urban China
Authors: Xiang Liqun , Shen Geoffrey Q P , Li Dandan , Tan Yongtao , Jin Xin 
Published: October 2021

Abstract

Background and Objectives
Although numerous efforts have been made to promote age-friendly communities (AFCs) in urban China, challenges such as the engagement and management of stakeholders, budget constraints, and policy issues remain. This article describes the work of designing a multi-agent platform (MAP) for the briefing stage of AFC projects.

Research Design and Methods
The process to design the MAP is first described, and the components and variables are identified. Then, a case study of a stakeholder consensus formation process is conducted using an agent-based simulation. Next, according to the simulation results, strategies to handle the conflicts arising among the stakeholders of AFC projects are proposed.

Results
According to the agent-based simulation conducted, both the initial approval rate and the outside connection rate will affect the stakeholder consensus formation process. Although a higher initial approval rate and a lower outside connection rate may reduce the average convergence time, the results show that 3–5 rounds of information exchange are still needed before a consensus or dissent is formed.

Discussion and Implications
Investors are suggested to communicate with residents and alleviate their concerns regarding AFC projects to facilitate the consensus formation process during the briefing stage of AFC projects; they can also organize activities for residents to exchange information and ideas. The simulation conducted, together with the MAP built in this research, will serve as a reference to help researchers and practitioners further understand the briefing stage and explore efficient strategies for the successful implementation of AFC projects in urban China.
Blowing-up Solutions for 2nd-Order Critical Elliptic Equations: The Impact of the Scalar Curvature
Authors: Robert Frédéric , Vétois Jérôme 
Published: October 2021

Abstract
Given a closed manifold $(M^n,g)$, $n\geq 3$, Druet [5, 7] proved that a necessary condition for the existence of energy-bounded blowing-up solutions to perturbations of the equation $$ \begin{align*} &\Delta_gu+h_0u=u^{\frac{n+2}{n-2}},\ u&gt;0 \ \textrm{in }M\end{align*}$$is that $h_0\in C^1(M)$ touches the Yamabe potential somewhere when $n\geq 4$ (the condition is different for $n=6$). In this paper, we prove that Druet’s condition is also sufficient provided we add its natural differentiable version. For $n\geq 6$, our arguments are local. For the low dimensions $n\in \{4,5\}$, our proof requires to introduce a suitable mass that is defined only where Druet’s condition holds. This mass carries global information both on $h_0$ and $(M,g)$.
Swarming Behavior in Anopheles gambiae (sensu lato): Current Knowledge and Future Outlook
Authors: Baeshen Rowida 
Published: October 2021

Abstract
Effective management of insect disease vectors requires a detailed understanding of their ecology and behavior. In Anopheles gambiae sensu lato (s.l.) (Diptera: Culicidae) mating occurs during swarming, but knowledge of their mating behavior under natural conditions is limited. Mosquitoes mate in flight over specific landmarks, known as swarm markers, at particular locations. Swarms consist of males; the females usually approach the swarm and depart following copulation. The number of mating pairs per swarm is closely associated with swarm size. The shape and height of swarm markers vary and may depend on the environmental conditions at the swarm’s location. Male–male interactions in mosquito swarms with similar levels of attractive flight activity can offer a mating advantage to some individuals. Flight tone is used by mosquitoes to recognize the other sex and choose a desirable mate. Clarifying these and other aspects of mosquito reproductive behavior can facilitate the development of population control measures that target swarming sites. This review describes what is currently known about swarming behavior in Anopheles gambiae s.l., including swarm characteristics; mating within and outside of swarms, insemination in females, and factors affecting and stimulating swarming.
Detection and Establishment of Aedes notoscriptus (Diptera: Culicidae) Mosquitoes in Southern California, United States
Authors: Metzger Marco E , Wekesa J Wakoli , Kluh Susanne , Fujioka Kenn K , Saviskas Robert , Arugay Aaron , McConnell Nathan , Nguyen Kiet , Krueger Laura , Hacker Gregory M , Hu Renjie , Kramer Vicki L 
Published: October 2021

Abstract
Aedes notoscriptus (Skuse), the Australian backyard mosquito, is a pestiferous daytime-biting species native to Australia and the surrounding southwestern Pacific region. It is suspected to play a role in the transmission of several arboviruses and is considered a competent vector of dog heartworm, Dirofilaria immitis (Leidy). This highly adaptable mosquito thrives in natural and artificial water-holding containers in both forested and urbanized areas, from tropical to temperate climates, and has benefitted from a close association with humans, increasing in abundance within its native range. It invaded and successfully established in New Zealand as well as in previously unoccupied temperate and arid regions of Australia. Ae. notoscriptus was discovered in Los Angeles County, CA, in 2014, marking the first time this species had been found outside the southwestern Pacific region. By the end of 2019, immature and adult mosquitoes had been collected from 364 unique locations within 44 cities spanning three southern California counties. The discovery, establishment, and rapid spread of this species in urban areas may signal the global movement and advent of a new invasive container-inhabiting species. The biting nuisance, public health, and veterinary health implications associated with the invasion of southern California by this mosquito are discussed.
Diverticulitis of the appendix—case report and literature review
Authors: Bujold-Pitre Kristopher , Mailloux Olivier 
Published: October 2021

ABSTRACT
Appendiceal diverticulitis is a rare diagnostic most often mistaken for an acute appendicitis.
A 72-year-old man presented with a transfixing abdominal pain for 48 hours. Appendicitis was diagnosed on computed tomography scan, but a neoplasm could not be excluded. A laparoscopic hemicolectomy was performed after a surgical consensus considering the neoplastic appearance of the lesion and anatomical feature. Histopathology finally revealed an appendiceal diverticulitis.
Appendiceal diverticulum is a rare condition. Most will lead to an appendiceal diverticulitis, which present similarly to an appendicitis. Perforation rate and mortality rate are much higher in appendiceal diverticulitis than in appendicitis. Furthermore, appendiceal diverticular disease is strongly associated with neoplasms, especially mucinous neoplasms and thus pseudomyxoma peritonei.
Considering the high complication rate and malignant association, an appendicectomy in case of an appendiceal diverticulitis or of an incidental finding of appendiceal diverticulosis should be recommended to the patient.
Effectiveness and safety of subcutaneous abatacept in biologic-naïve RA patients at Week 52: A Japanese multicentre investigational study (ORIGAMI study)
Authors: Tamura Naoto , Azuma Takanori , Misaki Kenta , Yamaguchi Rei , Hirano Fuminori , Sugiyama Eiji , Kanai Daisuke , Murakawa Yohko , Oribe Motohiro , Kimata Takahito , Aoki Kazutoshi , Sugiura Tomoko , Takasugi Koji , Takakubo Yuya , Tomita Yasuyuki , Isozaki Takeo , Nanki Toshihiro , Katsuyama Naooki , Kuroiwa Takanori , Oshikawa Hideto , Kaneko Motohide , Fujinaga Hiroshi , Saito Kiwamu , Tanaka Eiichi , Inoue Eisuke , Yoshizawa Yuri , Matsumoto Shigeru , Yamanaka Hisashi , Harigai Masayoshi 
Published: October 2021

ABSTRACT

Objectives
To evaluate the effectiveness and safety of abatacept over 52 weeks in biologic-naïve rheumatoid arthritis (RA) patients with moderate disease activity in the prospective, 5-year, observational study (ORIGAMI study) in Japan.

Methods
Abatacept (125 mg) was administered subcutaneously once a week. Clinical outcomes included Simplified Disease Activity Index (SDAI) remission at Week 52 (primary endpoint), Japanese Health Assessment Questionnaire (J-HAQ), EuroQol 5-Dimension Questionnaire (EQ-5D), treatment retention, and safety. The results were compared with those of conventional synthetic disease-modifying antirheumatic drug (csDMARD) controls from the ongoing Institute of Rheumatology, Rheumatoid Arthritis (IORRA) registry.

Results
Overall, 325 patients were enrolled, with a mean age of 66.9 ± 12.7 years. The proportion of patients achieving SDAI remission (≤3.3) at Week 52 was 18.9% (95% CI: 14.3–23.6) and low disease activity (≤11) was 53.3% (95% CI: 47.4–59.1). A significant improvement was observed in J-HAQ and EQ-5D over 52 weeks in both the abatacept and csDMARD groups. The probability of abatacept treatment retention at Week 52 was 69.9% (95% CI: 64.7–75.5). Adverse events and serious adverse events were reported in 50.0% and 12.1% of patients, respectively.

Conclusions
Abatacept significantly improved disease activity, physical disability, and quality of life for up to 52 weeks in RA patients in a real-world setting.
ESC: a comprehensive resource for SARS-CoV-2 immune escape variants
Authors: Rophina Mercy , Pandhare Kavita , Shamnath Afra , Imran Mohamed , Jolly Bani , Scaria Vinod 
Published: October 2021

Abstract
Ever since the breakout of COVID-19 disease, ceaseless genomic research to inspect the epidemiology and evolution of the pathogen has been undertaken globally. Large scale viral genome sequencing and analysis have uncovered the functional impact of numerous genetic variants in disease pathogenesis and transmission. Emerging evidence of mutations in spike protein domains escaping antibody neutralization is reported. We have built a database with precise collation of manually curated variants in SARS-CoV-2 from literature with potential escape mechanisms from a range of neutralizing antibodies. This comprehensive repository encompasses a total of 5258 variants accounting for 2068 unique variants tested against 230 antibodies, patient convalescent plasma and vaccine breakthrough events. This resource enables the user to gain access to an extensive annotation of SARS-CoV-2 escape variants which would contribute to exploring and understanding the underlying mechanisms of immune response against the pathogen. The resource is available at http://clingen.igib.res.in/esc/.
Case Series: Cystic Brain Metastases Managed With Reservoir Placement and Stereotactic Radiosurgery
Authors: Park David J , Unadkat Prashin , Goenka Anuj , Schulder Michael 
Published: October 2021

Abstract

BACKGROUND
Stereotactic radiosurgery (SRS) has become one of the mainstays of treatment for patients with metastatic brain tumors. However, metastatic tumors with a large cystic component often exceed the size limit for safe and effective SRS. In such cases, surgical resection may not be the preferred first method of treatment, due to tumor location, patient co-morbidities, and patient preference. In these patients, volume reduction by cyst aspiration (CA) followed by SRS may be a viable alternative treatment option.

OBJECTIVE
To present the treatment of patients with cystic metastases using reservoir placement followed by SRS.

METHODS
Nine patients were treated with this method. We performed reservoir insertion for the aspiration of cystic component in each patient and followed that with outpatient SRS.

RESULTS
Mean overall volume reduction from this treatment method was 78.5%. Mean volume reduction from the CA alone was 59.8%, and after SRS, a further 66.6%, accounting for some cyst reaccumulation between the time of surgery and SRS. Repeat reservoir aspiration was done a total of 10 times in 5 patients. Our study showed local tumor control in 7 of 9 patients (77.8%), while 2 patients required later surgical resection of their tumors.

CONCLUSION
CA with reservoir placement followed by SRS is a good option for patients with large cystic brain metastases. The reservoir allows for repeat aspiration if needed. Catheter placement at the center of the cyst, and SRS within 2 to 3 wk of surgery, can maximize the likelihood of a successful outcome.
Feasibility of SARS-CoV-2 Antibody Testing in Remote Outpatient Trials
Authors: Lofgren Sarah M , Okafor Elizabeth C , Colette Alanna A , Pastick Katelyn A , Skipper Caleb P , Pullen Matthew F , Nicol Melanie R , Bold Tyler D , Bangdiwala Ananta S , Engen Nicole W , Collins Lindsey , Williams Darlisha A , Axelrod Margaret L , Thielen Beth K , Hullsiek Kathy H , Boulware David R , Rajasingham Radha 
Published: October 2021

Abstract

Background
During the Covid-19 pandemic, clinical trials necessitated rapid testing to be performed remotely. Dried blood spot (DBS) techniques have enabled remote HIV virologic testing globally and more recently, antibody testing as well. We evaluated DBS testing for SARS-CoV-2 antibody testing in outpatients to assess seropositivity.

Methods
In 2020, we conducted three internet-based randomized clinical trials and offered serologic testing via self-collected DBS as a voluntary sub-study. COVID-19 diagnosis was based on CDC case definition with epidemiological link to cases. A minority reported PCR testing at an outside facility. We tested for anti-SARS-CoV-2 immunoglobulin via Antibody Detection by Agglutination-PCR (ADAP) and compared with ELISA.

Results
Of 2727 participants in the primary studies, 60% (1648/2727) consented for serology testing; 56% (931/1648) returned a usable DBS sample. Of those asymptomatic, 5% (33/707) had positive ADAP serology. Of participants with a positive PCR, 67% (36/54) had positive SARS-CoV-2 antibodies. None of those who were PCR-positive and asymptomatic were seropositive (0/7). Of 77 specimens tested for concordance via ELISA, 83% (64/77) were concordant.
Challenges of completing a remote testing program during a pandemic included sourcing and assembling collection kits, delivery and return of the kits, and troubleshooting testing. Self-collection was successful for &gt;95% of participants. Delays in US mail with possible sample degradation and timing of DBS collection complicated the analysis.

Conclusion
We found remote antibody testing during a global pandemic feasible although challenging. We identified an association between symptomatic COVID-19 and positive antibody results at similar prevalence to other outpatient cohorts.
High-spatial resolution long-mid-infrared observations of massive star-forming regions: Local star formation sequence
Authors: Uchiyama Mizuho , Miyata Takashi , Sako Shigeyuki , Kamizuka Takafumi , Asano Kentaro , Nakamura Tomohiko , Yamashita Takuya , Fujiyoshi Takuya , Yoneda Mizuki , Konishi Masahiro , Koshida Shintaro , Motohara Kentaro , Tanabé Toshihiko , Kitagawa Yutaro , Tateuchi Ken , Yoshii Yuzuru 
Published: October 2021

Abstract
The formation of massive stars in dense and cold molecular clouds is a fundamental problem in star formation. In this work, we studied three compact massive star-forming regions, M8E, RAFGL 6366S, and IRAS 18317−0513, to investigate the environment of massive star formation, specifically the possibility of a local feedback process. Our new mid-infrared observations using miniTAO/MAX38 at 31 and 37 μm resolved individual objects in each region and allowed us to obtain their individual luminosities and masses. Together with existence/absence of ultra-compact H ii regions, it is suggested that less-massive objects are more evolved than the more-massive objects in two out of the three regions. Because the objects that are more massive evolve faster, those that are less massive form earlier. This formation trend of local mass-sequential star was first suggested in 0.1 pc-scale massive star-forming regions. Therefore, feedback, such as outflows, jets, or radiative heating, from previously formed lower-mass young stellar objects might affect the environment of parental clouds and lead to next-generation massive young stellar objects.
O002 Medical therapy for sleep disordered breathing in children: a randomised, double-blind placebo-controlled trial
Authors: Baker A , Grobler A , Davies K , Griffiths A , Hiscock H , Kubba H , Peters R , Ranganathan S , Rimmer J , Rose E , Rowe K , Simpson C , Davidson A , Nixon G , Perrett K 
Published: October 2021

Abstract

Background
Sleep Disordered Breathing (SDB) in children is characterised by snoring and breathing difficulties during sleep. Small clinical trials suggest intranasal corticosteroids reduce SDB severity as defined by polysomnography. We assessed the efficacy of intranasal corticosteroid for improving symptoms and quality of life (QOL) in children with SDB.

Methods
This is a double-blind, randomised, placebo-controlled trial of healthy children 3-12y referred to a specialist with SDB symptoms. Exclusions were previous adenotonsillectomy, obesity or severe SDB. Participants received daily intranasal mometasone furoate 50micrograms or normal saline for 6 weeks. The primary outcome was resolution of symptoms measured by SDB score. Secondary outcomes were SDB symptom scores, QOL, behaviour, parent and surgeon perceived need for surgery, and parent satisfaction with treatment.

Results
276 participants were recruited; 138 in each group. 127 and 123 participants had primary outcome data at 6 weeks in the mometasone and saline groups respectively. Baseline age, atopic history, symptom severity and QOL were similar between groups. Resolution of SDB symptoms occurred in 44% [95%CI 35–53] of the mometasone group and 40% [95%CI 32–49] of the saline group; risk difference 4% [95%CI -0.8–16] p=0.511. Secondary outcomes were not different between groups.

Discussion
This large RCT, using clinical rather than polysomnographic outcomes to investigate the efficacy of mometasone on symptoms of SDB, found substantial rates of symptom resolution after 6 weeks in both groups. However, we found no difference in treatment effect between 6 weeks of intranasal mometasone over saline, for management of SDB symptoms in childhood.