bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaboration Networks of the Implementation Science Centers for Cancer Control (ISC3): A Social Network Analysis
Authors: Jacob Rebekah R , Korn Ariella R , Huang Grace C , Easterling Douglas , Gundersen Daniel A , Ramanadhan Shoba , Vu Thuy , Angier Heather , Brownson Ross C , Haire-Joshu Debra , Oh April , Schnoll Robert 
Published: December 2021

Abstract
Background: Multi-center research initiatives offer opportunities to develop and strengthen connections among researchers. These initiatives often have goals of increased scientific collaboration which can be examined using social network analysis.Methods: The National Cancer Institute (NCI)-funded Implementation Science Centers in Cancer Control (ISC3) initiative conducted an online social network survey in its first year of funding (2020) to examine early scientific linkages among members (faculty, staff, trainees) and recognize areas for network growth. Members of the seven funded centers and NCI program staff identified collaborations in: planning/conducting research, capacity building, product development, scientific dissemination, practice/policy dissemination.Results: Of the 192 invitees, 182 network members completed the survey (95%). The most prevalent roles were faculty (60%) and research staff (24%). Almost one-quarter (23%) of members reported advanced expertise in implementation science (IS), 42% intermediate, and 35% beginner. Most members were female (69%) and white (79%). Across all collaboration activities, the network had a density of 14%, suggesting high cohesion for its first year. One-third (33%) of collaboration ties were between members from different centers. Degree centralization (0.33) and betweenness centralization (0.07) measures suggest a fairly saturated network (no one or few central member(s) holding all connections). The most prevalent and densely connected collaboration network was for planning/conducting research (1470 ties; 8% density). Practice/policy dissemination had the fewest collaboration ties (284), lowest density (3%), and largest number of non-connected members (n=43). Median degree (number of collaborations) varied across member characteristics and collaboration activities. Members with advanced IS expertise were more connected than intermediate/beginner groups for most activities (e.g., advanced IS members had a median of 24 capacity building collaborations (range: 4-58) vs. intermediate (median 9; range 2-53) and beginner (median 7; range 1-49) members. The number of practice/policy dissemination collaborations were similarly low across IS expertise levels (median degree 3 for advanced, 2 intermediate, 2 beginner). Conclusions: Results provide important directions for interventions within the ISC3 network to increase scientific collaboration and capacity, with a focus on growing cross-center collaborations and increasing engagement of under-represented groups. Findings will be used to capture infrastructure development as part of the initiative’s evaluation.
Freeze-thaw Assessment of Plants Based on Envelope Analysis of Stem Volume Water Content Sequence
Authors: Tian Hao , Gao Chao , Zhang Xin , Xiao Hongbing , Yu Chongchong 
Published: December 2021

Abstract
Background: Frost stress is an abiotic stressor for plant growth that impacts the health and the regional distribution of plants. The freeze-thaw characteristics of plants during the overwintering period help to understand relevant issues in plant physiology, including plant cold resistance and cold acclimation. Therefore, we aimed to develop a non-invasive instrument and method for accurate in situ detection of changes in stem freeze-thaw characteristics during the overwintering period. Results: A sensor was designed based on standing wave ratio method (SWR) to measure stem volume water content (StVWC). We were able to measure stem volume ice content (StVIC) and stem freeze-thaw rate of ice (StFTRI) during the overwintering period. The resolution of the StVWC sensor is less than 0.05 %, the mean absolute error and root mean square error are less than 1 %, and the dynamic response time is 0.296 s. The peak point of the daily change rate of the lower envelope of the StVWC sequence occurs when the plant enters and exits the overwintering period. The peak point can be used to determine the moment of freeze-thaw occurrence, whereas the time point corresponding to the moment of freeze-thaw coincides with the rapid transition between high and low ambient temperatures. In the field, the StVIC and StFTRI of Juniperus virginiana L., Lagerstroemia indica L. and Populus alba L. gradually increased at the beginning, fluctuated steadily during, and then gradually decreased by the end of the overwintering period. The StVIC and StFTRI also showed significant variability due to differences among the tree species and latitude.Conclusions: The StVWC sensor has good resolution, accuracy, stability, and sensitivity. The envelope changes of the StVWC sequence and the correspondence between the freeze-thaw moment and the ambient temperature indicate that the determination of the freeze-thaw moment based on the peak point of the daily change rate of the lower envelope is reliable. The results show that the sensor is able to monitor changes in the freeze-thaw characteristics of plants and effectively characterize freeze-thaw differences and cold resistance of different tree species. Furthermore, this is a cost-effective tool for monitoring freeze-thaw conditions during the overwintering period.
Global pattern of ecosystem respiration tendencies and its implications on terrestrial carbon sink potential
Authors: Yu Peixin , Zhou Tao , Luo Hui , Liu Xia , Shi Peijun , Zhang Jingzhou , Zhang Yajie , Zhou Peifang , Xu Yixin 
Published: December 2021

Abstract
As the largest component of carbon export from terrestrial ecosystems, ecosystem respiration (RECO) determines the carbon stock changes in terrestrial ecosystems. It is essential to accurately simulate the response of RECO to climate change. In this study, by constructing an optimal deep learning model for simulating global-scale RECO, we found that there is a 1–2 years' lagged response of RECO to changes in water conditions and an inconsistency in carbon input (NPP) and output (RECO) trends. The NPP growth trend in global terrestrial ecosystems is greater than that of RECO, with a trend showing increasing carbon sinks, particularly in the northern extra-tropics; while the carbon sink capacity of tropical regions has gradually saturated, showing that the changing trend of RECO is close to that of NPP, which poses a potential risk to the sustainable carbon sink capacity of global ecosystems in the future.
Inhibitory Activity and Mechanism of Silver Nanoparticles Against Herpes Simplex Virus Type 1
Authors: Pan Xuanhe , Zhang Yapeng , Zhao Yiming , Yao Siqi , Guan Chaxiang , Wang Linqian , Chen Liyu 
Published: December 2021

Abstract
Herpes simplex virus type 1 (HSV-1) is a common pathogen that infects 50-90% of the world's population and causes a variety of diseases, some of which can be life-threatening. Silver nanoparticles (AgNPs) have been proven to have broad spectrum antiviral activity. In this study, we investigated the activity of AgNPs against HSV-1 by means of some antiviral tests and transmission electron microscopy (TEM). The results of antiviral tests demonstrated that AgNPs effectively inhibited the plaque formation and progeny production of HSV-1, reduced the genomic load and interfered with the mRNA expression and the protein synthesis of HSV-1. TEM observed that AgNPs could interact with HSV-1 and deform the HSV-1 particles. Furthermore, AgNPs could affect HSV-1’s entry into cells, HSV-1’s release and cell-to-cell spread. AgNPs could also down-regulate the expression of pro-inflammatory cytokines upon HSV-1 infection. In addition, the combined treatment of AgNPs and Acyclovir (ACV) confirmed that AgNPs could significantly enhance the inhibitory effect of ACV against HSV-1. Our findings offer a new insight into clarifying the mechanism of AgNPs against HSV-1, thus providing a theoretical basis for its clinical application.
A Shift From Competition To Facilitation With Abiotic Stress is Limited For Two Codominant Grass Species
Authors: Gray Jesse E. , Smith Melinda D. 
Published: December 2021

Abstract
It remains unclear how competitive exclusion is avoided between two ecologically, economically, and culturally important codominant grass species in the tallgrass prairie of the Great Plains, Andropogon gerardii and Sorghastrum nutans. These functionally similar C4 grasses appear to coexist despite considerable niche overlap, and asymmetric competition and drought tolerance in favor of A. gerardii. According to the stress gradient hypothesis, it may be that the sum of interactions between these species, which is typically negative (competitive) due to similar resource requirements, shifts to positive (facilitative) as abiotic stress increases. For instance, if the canopy cover of the stronger competitor reduces losses of subcanopy humidity or shallow soil moisture, recruitment of S. nutans tillers may be extended further into the drought event than would occur in the absence of A. gerardii. As later months of the growing season are drier on average where these species are codominant, such a mechanism may enable S. nutans to recover from early season asymmetric competition and stabilize their codominance. We tested this hypothesis in a greenhouse experiment in which we manipulated community composition and water availability in the latter half of the growing season. We found no evidence that a shift from a negative to positive interaction occurs, with each species performing similarly in mixed communities and monocultures. The similarities of the two species in their functional traits and responses to water limitations may limit such a shift in interaction net effects and suggests that other mechanisms are determining coexistence of these co-occuring C4 grasses.
Comparing The Efficacy of Sevoflurane To Propofol For Inflammatory Response During Venovenous Extracorporeal Membrane Oxygenation
Authors: Zhang Rongzhi , Huang Jian , Yang Jianbao , Cheng Xingdong , Zhai Kerong , Wei Shilin , Li Jian , Li Yongnan , Gao Bingren 
Published: December 2021

Abstract
Background: Acute respiratory distress syndrome (ARDS), a clinical syndrome resulting from intrapulmonary and/or extrapulmonary causes, is characterized by refractory hypoxemia. Currently, venovenous extracorporeal membrane oxygenation (VV ECMO) is considered as a reasonable alternative to salvage ARDS, but it requires sedation of the patient. Several studies suggest that anesthetics, such as sevoflurane and propofol, have lung protective and immunomodulatory functions. The aim of this study was to explore the effects of sevoflurane and propofol on ARDS in VV ECMO rat models.Methods: To establish the ARDS model, male Sprague-Dawley (SD) rats were injected with 100mg/kg oleic acid (OA). Twenty-four SD rats were randomly divided into two groups: sevoflurane group (Sevo group) and propofol group (Pro group). The basic vital signs of rats in each group were continuously monitored using a life monitor, and arterial blood gas tests were performed at the following three time points: T0 (baseline), T1 (the time to ARDS), and T2 (after weaning from ECMO for 1 h). Bicinchoninic acid assay (BCA) method was used to determine protein concentration in bronchial alveolar lavage fluid (BALF), whereas hemotaxylin and eosin (HE) staining was used to evaluate the lung pathological scores in each group. In addition, inflammatory factors (IL-1b, TNF-a, and MPO) in BALF, serum, and lung were determined using enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC).Results: With regard to the blood gas index, the Sevo group exhibited a better effect in improving the oxygenation function than the Pro group (P<0.05). However, there was no significant difference in mean arterial pressure (MAP) between the two groups (P>0.05). After VV ECMO assistance, the degree of lung injury and inflammatory changes in the Sevo group were significantly reduced compared to the Pro group.Conclusion: This study shows that sedation with sevoflurane during VV ECMO assisted ARDS in rats improved lung injury and inflammation, and was better than propofol in improving the oxygenation function.
Novel Gene Rearrangement in the Mitochondrial Genome of Anastatus Fulloi (Hymenoptera Chalcidoidea) and Phylogenetic Implications for Chalcidoidea
Authors: Yi Jiequn , Wu Han , Liu Jianbai , Li Jihu , Lu Yinglin , Zhang Yifei , Cheng Yinjie , Guo Yi , Li Dunsong , An Yuxing 
Published: December 2021

Abstract
The genus Anastatus comprises a large group of parasitoids, including several biological control agents in agricultural and forest systems. The taxonomy and phylogeny of these species remain controversial. In this study, the mitogenome of A. fulloi Sheng and Wang was sequenced and characterized. The nearly full-length mitogenome of A. fulloi was 15,692 bp, compromising 13 protein-coding genes (PCGs), 2 rRNA genes, and 22 tRNA genes and a control region (CR). The total A + T contents were 83.83%, 82.18%, 87.58%, 87.27%, and 82.13% in the whole mitogenome, 13 PCGs, 22 tRNA genes, 2 rRNA genes, and CR, respectively. The mitogenome presented negative AT skews and positive GC skews, except for the CR. Most PCGs were encoded on the majority strand, started with ATN codons, and ended with TAA codons. Among the 3736 amino acid-encoding codons, TTA (Leu1), CGA (Arg), TCA (Ser2), and TCT (Ser2) were predominant. Most tRNAs had cloverleaf secondary structures, except trnS1, with the absence of a dihydrouridine (DHU) arm. Compared with mitogenomes of the ancestral insect and another parasitoid within Eupelmidae, large-scale rearrangements were found in the mitogenome of A. fulloi, especially inversions and inverse transpositions of tRNA genes. The gene arrangements of parasitoid mitogenomes within Chalcidoidea were variable. A novel gene arrangement was presented in the mitogenome of A. fulloi. Phylogenetic analyses based on the 13 protein-coding genes of 20 parasitoids indicated that the phylogenetic relationship of 6 superfamilies could be presented as Mymaridae + (Eupelmidae + (Encyrtidae + (Trichogrammatidae + (Pteromalidae + Eulophidae)))). This study presents the first complete mitogenome of the Anastatus genus and offers insights into the identification, taxonomy, and phylogeny of these parasitoids.
Two-Dimensional Biocompatible Plasmonic Lenses for Color Blindness Correction
Authors: Roostaei N. , Hamidi S. M. 
Published: December 2021

Abstract
Color blindness, or color vision deficiency (CVD), is an ocular disease that suppresses the recognition of different colors. Recently, tinted glasses and lenses have been studied as hopeful devices for color blindness correction. In this study, 2D biocompatible and flexible plasmonic lenses were fabricated using polydimethylsiloxane (PDMS) and an innovative, low-cost, and simple design based on the soft nano-lithography method. These lenses were investigated for correction of red-green (deuteranomaly) color blindness. The plasmonic lens proposed herein is based on the plasmonic surface lattice resonance (SLR) phenomenon and offers a good color filter for color blindness correction. The biocompatibility, low cost, and simple fabrication of these contact lenses can offer new insights for applications of color blindness correction.
Dating submarine landslides using the transient response of gas hydrate stability
Authors: Portnov Alexey , You Kehua , Flemings Peter , Cook Ann , Heidari Mahdi , Sawyer Derek 
Published: December 2021

Abstract
Submarine landslides are prevalent on the modern-day seafloor, yet an elusive problem is constraining the timing of slope failure. Herein, we present a novel technique for constraining the age of submarine landslides without sediment core dating. Underneath a submarine landslide in the Orca Basin, Gulf of Mexico, in 3D seismic data we map an irregular bottom simulating reflection (BSR), which mimics the geometry of the pre-slide seafloor rather than the modern bathymetry. Based on the observed BSR, we suggest that the gas hydrate stability zone (GHSZ) is currently adjusting to the post-slide sediment temperature perturbations. We apply transient conductive heat flow modeling to constrain the response of the GHSZ to the slope failure, which yields a most likely age of ~8 ka demonstrating that gas hydrate systems can respond to slope failures even on the millennia timescales. We also provide an analytical approach to rapidly determine the age of submarine slides at any location.
An Investigation of the Mechanism on Interfacial Charge Transformation of the TiB2/Cu Composites Studied by the First Principles
Authors: Shu Yao , Wang Juan , Xiong Yongnan , Luo Xing , He Jiazhen , Yin Cuicui , Gao Fei , Zhang Shaowen , Zheng Kaihong , Yin Fuxing , Pan Fusheng 
Published: December 2021

Abstract
The charge communications have been widely existed in the metal materials when they are under the processing, the modeling and the failing. We studied the interfacial charge transformation of the TiB2/Cu composites via the first principles method. The layer thickness was predicted by the interfacial charge communications performed on the regions of the TiB2/Cu interfaces. The layer thickness of the Ti-terminated (TT)TiB2/Cu were predicted longer than those of the B-terminated(BT) TiB2/Cu and contrasting with their average vales as 0.75 (nm) and 0.65 (nm), respectively. The Mulliken population was applied to investigate the bond length, bond population and charge transformation of the six TiB2/Cu models. The Ti-Cu bond was only detected in TT-HCP interfaces among the all TT-TiB2/Cu models, which was further confirmed that the metallic bond of the Ti-Cu with the bond length and population as 2.5 Å and 0.22, respectively. Nevertheless, the B-Cu bond were detected in all BT-TiB2/Cu models, and the bond length and population higher than those of B-Cu bond in chemical complexes. The 5 atomic layers were involved in quantitative analyses of the interfacial charge transformation. The results indicate that the charges lost by interfacial Ti atom were inequivalent obtained by Cu and B atoms which nearby the interfacial Ti atoms of the TT-TiB2/Cu. Comparing with the BT-TiB2/Cu models, the charges acquired by the interfacial B atom were most from the Ti and less from the Cu atoms surrounded the interfacial B atoms.
Knockdown of TRIM66 Suppresses the Proliferation, Migration, Invasion and Glycolysis in Cholangiocarcinoma Cells
Authors: Jiang Lei , Li Yuqiang , Li Yan , Yang Tao , Li Dongsheng , Li Nan , Yang Weiwei 
Published: December 2021

Abstract
Background: The tripartite motif (TRIM) family proteins feature highly conserved order of domains in the RBCC motif and most of them play an essential role in various cellular processes. Recently, increasing evidence has shown association of TRIM proteins with cancer development. In this study, we examined the expression pattern and biological functions of TRIM66 in cholangiocarcinoma (CCA).Methods: Western blot was performed for the protein levels of TRIM66, E-cadherin, α-catenin, N-cadherin, vimentin, p-PI3K, PI3K, p-Akt and Akt. MTT assay, wound healing assay and transwell assay were conducted for cell proliferation, migration and invasion, respectively. Glucose uptake and lactate production were determined using specific kits.Results: TRIM66 was overexpressed in CCA tissues and cell lines. In addition, knockdown of TRIM66 significantly inhibited proliferation, migration, invasion and glycolysis of CCA cells. Moreover, TRIM66 silencing obviously decreased levels of phosphorylated PI3K and Akt in CCA cells.Conclusion: Our study provided a novel insight into the roles of TRIM66 in CCA and suggested TRIM66 as a promising therapeutic target for CCA treatment.
Changes in Ciliate Communities Reveal Modification of Lake Functioning Over the Last Century
Authors: Cécilia Barouillet , Vasselon Valentin , Keck François , Millet Laurent , Etienne David , Galop Didier , Rius Damien , Domaizon Isabelle 
Published: December 2021

Abstract
Ciliates are unicellular heterotrophic organisms that play a key role in the planktonic and benthic food webs of lakes, and represent a great potential as bioindicator. In this study, we used the top-bottom paleolimnological approach to compare the recent and past (i.e. prior to major anthropogenic impacts) ciliate communities of 48 lakes located along an elevation gradient using metabarcoding techniques applied on sedimentary DNA (sed-DNA). Our results show an overall decline in the β-diversity in recent time, especially in lowland lakes which are more strongly expose to local human pressure. Analyses of the functional groups indicate important restructuration of the trophic food web and changes that are consistent with several well documented environmental changes such as the widespread increase in deep water anoxia, changes in thermal stability and nutrient cycling. Our study demonstrates the potential offered by sed-DNA to uncover information about past ciliate communities on a wide variety of lakes and the potential of using ciliates as valuable indicators, integrating information from the pelagic to the benthic profundal (and littoral) zones. Through trait-based functional community approach, the ciliates provide additional valuable information on ecosystem functioning, thus offering more a holistic view on the long-term changes of aquatic ecosystems.