bluuebunny/crossref_metadata_2025_split huggingface dataset:
Segen Interaktiv: die Interdisziplinäre Entwicklung Eines Außerschulischen Lernortes zu Interreligiösen Segensräumen
Authors: Nord Ilona , Wolf Sara , Luthe Simon , Hurtienne Jörn , Schleier Leon 
Published: December 2024

ZusammenfassungReligionskulturen nehmen zunehmend Designformate von Digital Religion an. Dabei zeigt sich als religionspädagogisch nahezu unerforscht die didaktisch reflektierte User Experience und das Design von digitalen Lehr- und Lernszenarien. AP6 geht aus der Perspektive der interdisziplinären Zusammenarbeit von Human–Computer Interaction und Ev. Religionspädagogik davon aus, dass Religionen und mit ihnen Glaubenspraxen am gesellschaftlichen Wandel zu einer Kultur der Digitalität teilhaben. Es wird auf vorangehende Studien aufgebaut, die zeigen, dass die Erwartung von Lehrpersonen, guten Unterricht mit digitalen Medien gestalten zu können, von positiven Vorerfahrungen mit diesen abhängt. Das Projekt greift hierfür exemplarisch die innerhalb von digitalen Kommunikationen verbreitete religiöse Urgeste des Segens und Segnens auf. In einem iterativen Prozess entstanden interaktive Exponate, sogenannte Blessing Machines. Sie wurden entlang psychologischer Bedürfnisse mit dem Ziel gestaltet, für Schüler:innen und ihre Lehrpersonen religionserschließende Erfahrungen mit digitalem Lernen zu ermöglichen. 200 Personen testeten die dreizehn Blessing Machines (Schulklasse, Konfirmandengruppen) in the wild. Religionslehrpersonen wurden hierbei von der „Logistik“ des Einsatzes digitaler Medien im Unterricht entlastet. Der außerschulische Lernort erfüllte die wichtige Funktion, Schüler:innen und Lehrpersonen gelingende Erfahrungen mit Digital Religion zu ermöglichen. Die Gestaltung der Blessing Machines hat sich als wirksam herausgestellt, besonders Aspekte von Autonomie, Stimulation, Verbundenheit, Gemeinschaft und Provokation wurden positiv hervorgehoben.
Empathiesteuerung in Musikvideos
Authors: Haase Volker 
Published: December 2024

ZusammenfassungZu den wichtigen Themen in der Arbeit Bettina Bussmanns zählen, neben dem konsequenten Einbezug empirischer Wissenschaften in das Philosophieren im Allgemeinen, auch konkrete Fragestellungen zur Verbindung von Philosophie und Psychologie, die im österreichischen Schulwesen traditionell sehr eng ist. Eines ihrer Interessengebiete stellt in diesem Zusammenhang die Philosophie der Gefühle dar, wobei es ihr u. a. um das fachdidaktische Verständnis und um die Rolle von Empathie in persönlichkeitsbildenden Prozessen im Philosophie- und Ethikunterricht geht. Der nachfolgende Artikel setzt hier an und widmet sich dem Thema eines Philosophierens mit Musikvideos unter besonderer Berücksichtigung der Empathiesteuerung bei den Zuschauenden im Zusammenspiel von Liedtexten und filmischen Darstellungsmitteln.
Die Beförderung intellektueller Autonomie und der angemessene Umgang mit wissenschaftlicher Expertise
Authors: Balg Dominik 
Published: December 2024

ZusammenfassungBettina Bussmann hat bereits in ihrer Dissertationsschrift mit Überlegungen zu Möglichkeiten der angemessenen Identifizierung wissenschaftlicher Expertise und deren Bedeutung für den Philosophie- und Ethikunterricht ein wichtiges Problemfeld für die philosophiedidaktische Forschung zu einem Zeitpunkt eröffnet, zu dem die entsprechende fachphilosophische Forschung noch in ihren Kinderschuhen steckte. Da dieses Problemfeld bis heute nichts an Relevanz eingebüßt hat und die erkenntnistheoretische Literatur zu diesem Thema in den letzten Jahren ein hohes Maß an Ausdifferenzierung erfahren hat, erscheint eine intensivere philosophiedidaktische Debatte dringend erforderlich. In diesem Beitrag arbeite ich anhand einer Rekonstruktion von Bussmanns Überlegungen und eines exemplarischen Abgleichs der diesen Überlegungen zugrundeliegenden fachphilosophischen Literatur mit aktuellen erkenntnistheoretischen Diskursen verschiedene Desiderate und Anknüpfungspunkte für eine solche Debatte heraus.
Philosophische Bildung als Aufklärung
Authors: Rohbeck Johannes 
Published: December 2024

ZusammenfassungIm Zentrum der Philosophiedidaktik von Bettina Bussmann steht die Vermittlung von Philosophie, Lebenswelt und Wissenschaft. Um dieses Spannungsverhältnis zu verdeutlichen, entwirft Bussmann ein „Philosophiedidaktisches Dreieck“, an dessen Spitze die Philosophie steht (Bussmann 2014, 2015). Auf der einen Seite bezieht sich die Philosophie auf die Lebenswelt, deren Probleme sie reflektiert. Wichtig ist dabei, dass sich die Lebenswelt nicht auf das individuelle und subjektive Erleben der Menschen beschränkt, sondern jetzt die gesellschaftliche Dimension mit einschließt, zu der wesentlich der Umgang mit den Wissenschaften gehört.
Vaccine Recommendations and Epistemic Competence
Authors: Werndl Charlotte 
Published: December 2024

AbstractIn this contribution I will start in Sect. 2 by introducing epistemic competence. I will stress that like Bussmann, I regard it as fundamental that people in a democratic society possess epistemic competence and that it would be important to teach epistemic competence at school. In Sect. 3 I show that even for countries where the epidemiological situation is roughly the same or very similar such as Austria, Germany and Switzerland, there are often very different recommendations concerning vaccinations. In Sect. 4 I will identify and discuss five rational reasons that can alone or in combination lead to different vaccine recommendations. Finally, Sect. 5 will reflect on epistemic competence and vaccine recommendations. In particular, I will point out that different vaccine recommendations are an example where students can develop epistemic competence. Further, I will stress that different vaccine recommendations are an example where epistemic competence among the general population is desirable; if it is not present, this can lead to science scepticism and mistrust about science.
Effiziente Therapie des leichten Morbus Crohn und der leichten Colitis ulcerosa
Authors: Rogler Gerhard 
Published: December 2024

Zusammenfassung
Grundstein der Behandlung der leichten Colitis ulcerosa ist nach wie vor die perorale oder topische (rektale) Anwendung von 5‑Aminosalicylaten (5-ASA). Häufig werden bei der leichten Colitis ulcerosa 5‑ASA-Präparate nur peroral verabreicht. Dabei zeigen Studiendaten, dass bei der Proctitis ulcerosa und der linksseitigen Kolitis rektale 5‑ASA-Applikationen sogar wirksamer sind als die orale Verabreichung. In einem nächsten Schritt sollten steroidhaltige topische Therapien eingesetzt werden. Beim leichten Morbus Crohn kommen primär topische Steroide wie Budesonid zum Einsatz. Bei symptomfreien Patienten ist aber umstritten, ob eine Therapie notwendig ist. Es fehlt nach wie vor die Evidenz, die nachweisen würde, dass die aggressivere Behandlung (mit Immunsuppressiva, Biologika oder „small molecules“) bei diesen Patienten einen Vorteil für den Langzeitverlauf hat. In den meisten Leitlinien wird der Einsatz von 5‑ASA bei leichtem Morbus Crohn kritisch gesehen. Dennoch existiert eine gewisse Evidenz für eine ausreichend hoch dosierte Therapie mit 5‑ASA, wobei man sich der limitierten Wirksamkeit bewusst sein muss. Für den postoperativen Einsatz von 5‑ASA bei einem leichten Rezidiv gibt es dagegen klare Evidenz.
Bilateral septic acromioclavicular arthritis in a farm worker with high suspicion of zoonotic disease: a case report
Authors: Barlow K. A. , Gütler J. 
Published: December 2024

Abstract

Introduction
We report the case of a 54-year-old male with the rare entity of bilateral septic acromioclavicular (AC) arthritis with osteomyelitis of the lateral clavicle with methicillin-susceptible Staphylococcus aureus (MSSA). The glenohumeral joint was affected as well. The patient was immunocompetent with no history of diabetes or intravenous drug abuse. There is a high possibility of a transmission from farm animals.

Material and methods
The case files including laboratory measurements, imaging and documentation were used to reassess the case and complete the case report. Regular clinical follow-up was done in our outpatient clinic. We compared our case with the literature and existing guidelines.

Results
We report this rare entity of bilateral septic AC arthritis to ensure early diagnosis and proper treatment in the future. In comparison to the existing guidelines, we followed similar treatment concepts. The outcome of our patient was satisfactory despite a pre-existing rotary cuff tear, which might need further treatment in the future.

Conclusion
This report of a rare case can help to understand this infectious disease in the future and help establish treatment guidelines. In farm workers, one should be highly suspicious of transmission through animals and establish a quick and effective treatment as we did in this case.
Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism
Authors: Ott Fritzi , Körner Christiane , Krohn Knut , Fischer Janett , Damm Georg , Seehofer Daniel , Berg Thomas , Matz-Soja Madlen 
Published: December 2024

Abstract
The Hedgehog (Hh) signaling pathway is essential for maintaining homeostasis during embryogenesis and in adult tissues. In the liver, dysregulation of this pathway often leads to liver cancer development. Recent studies also suggest that disturbances in the Hh pathway can affect liver metabolism in healthy livers through interactions with other signaling pathways, such as the Wnt/β-catenin pathway. As a result, the Hh pathway has emerged as a promising target for therapeutic intervention. However, little is known about the effects of Hh modulators on healthy hepatocytes. In our study, we investigated the effects of the Hh agonists SAG (300 nM) and triamcinolone acetonide (40 µM), as well as the antagonists RU-SKI 43 (100 nM), cyclopamine (5 µM), budesonide (25 µM), GANT61 (0.5 µM), and vismodegib (1 µM) on healthy mouse and human primary hepatocytes in vitro. We employed toxicological, transcriptomic, proteomic, and functional assays, including proliferation and Seahorse assays. Our results show that these compounds significantly impact metabolic pathways such as lipid and glucose metabolism at both transcriptional and protein levels. Mechanistically, our data suggest the involvement of both canonical and non-canonical Hedgehog pathways, a phenomenon not previously described in hepatocytes. These findings highlight the diverse effects of these compounds on signaling and key metabolic functions in the liver, which emphasizes the need to investigate the hepatic Hh cascade and its metabolic control in depth. As the compounds regulate different aspects of metabolism, they need to be carefully studied in appropriate model systems for specific therapeutic use.
On proper intersections on a singular analytic space
Authors: Andersson Mats , Samuelsson Kalm Håkan 
Published: December 2024

Abstract
Given a reduced analytic space Y we introduce a class of nice cycles, including all effective

$${\mathbb {Q}}$$

Q

-Cartier divisors. Equidimensional nice cycles that intersect properly allow for a natural intersection product. Using

$$\bar{\partial }$$

∂

¯

-potentials and residue calculus we provide an intrinsic way of defining this product. The intrinsic definition makes it possible to prove global formulas. In case Y is smooth all cycles are differences of nice cycles, and so we get a new way to define classical proper intersections.
Influence of CYP2C8*3 and ABCG2 C421A genetic polymorphisms on trough concentration and molecular response of imatinib in Egyptian patients with chronic myeloid leukemia
Authors: Mangoura Safwat A. , Abdel-Raheem Mahmoud H. , Eltyb Hanan A. , Molla Mohammed S. , Hussein Abeer M. R. 
Published: December 2024

Abstract
Purpose
The treatment landscape for chronic myeloid leukemia (CML) has been revolutionized by the introduction of imatinib, a tyrosine kinase inhibitor, which has transformed the disease from a fatal condition into a manageable chronic illness for a substantial number of patients. Despite this, some individuals do not respond adequately to the treatment, and others may experience disease progression even with continued therapy. This study examined how CYP2C8*3 (G416A; rs11572080) and ABCG2 C421A (rs2231142) single nucleotide polymorphisms (SNPs) affect the plasma trough concentration and therapeutic response of imatinib in Egyptian CML patients.

Methods
The study included fifty patients with chronic-phase CML, who were categorized into two groups: responders (n = 26) and non-responders (n = 24), according to their BCR-ABL1 transcription levels after 12 months of imatinib treatment. Genotyping of the CYP2C8*3 and ABCG2 C421A polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while plasma trough concentrations were determined through high-performance liquid chromatography with ultraviolet-diode array detection (HPLC-UV/DAD).

Results
Patients with the CA genotype of ABCG2 C421A showed significantly higher mean plasma trough concentrations of imatinib (CA: 1731 ± 424.7 ng/mL; CC: 1294 ± 381.3 ng/mL; p = 0.0132) and demonstrated a better molecular response compared to those with the CC genotype (p = 0.0395).

Conclusion
The ABCG2 C421A polymorphism significantly influenced imatinib plasma trough concentrations and molecular responses in Egyptian chronic-phase CML patients. Genotyping of this polymorphism in these patients could assist in optimizing imatinib therapy, predicting more favorable treatment outcomes, and enabling the development of more personalized treatment plans.
Lower extremity lymphedema in patients with gynecologic cancer: Validation of the Gynecologic Cancer Lymphedema Questionnaire (GCLQ) in German language and investigation of lymphedema real-world treatment
Authors: Meyer Henrike , Hinz Andreas , Weisgerber Christiane , Pilny Adrian , Dornhöfer Nadja , Mehnert-Theuerkauf Anja , Aktas Bahriye , Wolf Benjamin 
Published: December 2024

Abstract
Purpose
The Gynecologic Cancer Lymphedema Questionnaire (GCLQ) is an established patient-reported outcome measure for lower extremity lymphedema (LEL) in gynecologic oncology. We aimed to validate the GCLQ in German language (GCLQ-GER) for lymphedema detection in German-speaking patients and also investigated real-world patterns of lymphedema treatment.

Methods
The GCLQ was translated from English into German in accordance with the standards of a professional translation process. Subsequently, the questionnaire was administered in a prospective observational study including 102 patients who had undergone lymph node dissection (LND) within gynecologic cancer surgery. Various test quality criteria were calculated for the GCLQ-GER. As gold standard of testing methods, patients were clinically evaluated for LEL, and limb volume measurements were taken. Further data for lymphedema treatment were collected in patients with lymphedema diagnosis.

Results
Patients with LEL had increased GCLQ-GER total scores (mean 7.27) compared to patients without LEL (mean 1.81), p < 0.001. High diagnostic accuracy was indicated by the large area under the receiver operating characteristics curve (AUC) of 0.874 (95% CI 0.802–0.946). Based on sensitivity and specificity values ≥ 79.0%, the GCLQ total score ≥ 4 was determined as the optimal cut-off value to identify LEL. Excellent internal consistency was demonstrated by Cronbach’s alpha of 0.876. The clinical examination revealed a LEL prevalence of 48.0% (n = 49), and 85.7% (n = 42) of these patients received treatment.

Conclusion
The GCLQ-GER is a valid and feasible patient-reported outcome measure for lymphedema detection in German-speaking gynecologic cancer survivors. Its clinical introduction could improve secondary prevention of lymphedema and real-world treatment.
Enhancing waste sorting and recycling efficiency: robust deep learning-based approach for classification and detection
Authors: Sayem Faizul Rakib , Islam Md. Sakib Bin , Naznine Mansura , Nashbat Mohammad , Hasan-Zia Mazhar , Kunju Ali K Ansaruddin , Khandakar Amith , Ashraf Azad , Majid Molla Ehsanul , Kashem Saad Bin Abul , Chowdhury Muhammad E. H. 
Published: December 2024

Abstract
Given the severity of waste pollution as a major environmental concern, intelligent and sustainable waste management is becoming increasingly crucial in both developed and developing countries. The material composition and volume of urban solid waste are key considerations in processing, managing, and utilizing city waste. Deep learning technologies have emerged as viable solutions to address waste management issues by reducing labor costs and automating complex tasks. However, the limited number of trash image categories and the inadequacy of existing datasets have constrained the proper evaluation of machine learning model performance across a large number of waste classes. In this paper, we present robust waste image classification and object detection studies using deep learning models, utilizing 28 distinct recyclable categories of waste images comprising a total of 10,406 images. For the waste classification task, we proposed a novel dual-stream network that outperformed several state-of-the-art models, achieving an overall classification accuracy of 83.11%. Additionally, we introduced the GELAN-E (generalized efficient layer aggregation network) model for waste object detection tasks, obtaining a mean average precision (mAP50) of 63%, surpassing other state-of-the-art detection models. These advancements demonstrate significant progress in the field of intelligent waste management, paving the way for more efficient and effective solutions.
SWOOP: top-k similarity joins over set streams
Authors: Mann Willi , Augsten Nikolaus , Jensen Christian S. , Pawlik Mateusz 
Published: December 2024

Abstract
We provide efficient support for applications that aim to continuously find pairs of similar sets in rapid streams, such as Twitter streams that emit tweets as sets of words. Using a sliding window model, the top-k result changes as new sets enter the window or existing ones leave the window. Specifically, when a set arrives, it may form a new top-k result pair with any set already in the window. When a set leaves the window, all its pairings in the top-k result must be replaced with other pairs. It is therefore not sufficient to maintain the k most similar pairs since less similar pairs may become top-k pairs later. We propose SWOOP, a highly scalable stream join algorithm. Novel indexing techniques and sophisticated filters efficiently prune obsolete pairs as new sets enter the window. SWOOP incrementally maintains a provably minimal stock of similar pairs to update the top-k result at any time. Empirical studies confirm that SWOOP is able to support stream rates that are orders of magnitude faster than the rates supported by existing approaches.
Towards LES of Liquid Jet Atomization Using an Eulerian-Lagrangian Multiscale Approach
Authors: Trautner Elias , Hasslberger Josef , Klein Markus 
Published: December 2024

AbstractThis study is concerned with Large Eddy Simulation of liquid jet atomization using a two-way coupled Eulerian-Lagrangian multiscale approach. The proposed framework combines Volume-of-Fluid interface capturing with Lagrangian Particle Tracking. The former is used to compute the core jet and large liquid elements in the near-nozzle region, whereas the latter is used to track the large number of small droplets in the dilute downstream region of the spray. The convective and surface tension sub-grid scale terms arising in the context of two-phase flow LES are closed using suitable models, and secondary atomization is considered by employing a modified version of the Taylor Analogy Breakup model. The introduced framework is used to simulate an oil-in-air atomization as well as the Diesel-like Spray A test case of the Engine Combustion Network. Compared to previous studies based on Eulerian-Lagrangian methods, the present work stands out for the high-fidelity numerical approach, the complex test cases and the detailed comparison of the results to experimental data, which indicates a promising performance.
The Distorting Influence of Primacy Effects on Reporting Cognitive Load in Learning Materials of Varying Complexity
Authors: Krieglstein Felix , Beege Maik , Wesenberg Lukas , Rey Günter Daniel , Schneider Sascha 
Published: December 2024

AbstractIn research practice, it is common to measure cognitive load after learning using self-report scales. This approach can be considered risky because it is unclear on what basis learners assess cognitive load, particularly when the learning material contains varying levels of complexity. This raises questions that have yet to be answered by educational psychology research: Does measuring cognitive load during and after learning lead to comparable assessments of cognitive load depending on the sequence of complexity? Do learners rely on their first or last impression of complexity of a learning material when reporting the cognitive load of the entire learning material after learning? To address these issues, three learning units were created, differing in terms of intrinsic cognitive load (low, medium, or high complexity) as verified by a pre-study (N = 67). In the main-study (N = 100), the three learning units were studied in two sequences (increasing vs. decreasing complexity) and learners were asked to report cognitive load after each learning unit and after learning as an overall assessment. The results demonstrated that the first impression of complexity is the most accurate predictor of the overall cognitive load associated with the learning material, indicating a primacy effect. This finding contrasts with previous studies on problem-solving tasks, which have identified the most complex task as the primary determinant of the overall assessment. This study suggests that, during learning, the assessment of the overall cognitive load is influenced primarily by the timing of measurement.
Harnessing Soft Information to Promote Financial Inclusion: The Case of Business Lending by a Native CDFI
Authors: Dimitrova-Grajzl Valentina , Grajzl Peter , Vogel Lakota , Wheeler Laurel 
Published: December 2024

AbstractNative Community Development Financial Institutions (NCDFIs) promote financial inclusion in financially underserved Native communities by adopting innovative lending strategies, including designing their own soft-information-based measures of borrower risk. Drawing on business loan data from one prominent NCDFI, a nonprofit loan fund, we examine to what extent the NCDFI-generated borrower risk measures help explain the NCDFI's loan performance and pricing above and beyond the effect of the credit score, a conventional credit-bureau-produced, hard-information-based metric. All else equal, both loan delinquency hazard and loan interest rate are robustly predicted by one of the NCDFI's two proprietary soft-information-based measures, the character score, but do not vary with the other one, commitment to business score. The credit score is an important determinant of loan delinquency hazard but, all else equal, does not exhibit a detectable relationship with the loan interest rate. We do not find evidence of noteworthy interactions among the three NCDFI-used borrower risk measures. Our study offers evidence in support of the unique underwriting practices and relationship-based lending operations that characterize the NCDFI industry.