bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Digital Patient-Reported Outcome Platform (Noona) for Clinical Use in Patients With Cancer: Pilot Study Assessing Suitability
Authors: Peltola Maria Kristiina , Poikonen-Saksela Paula , Mattson Johanna , Parkkari Timo 
Published: May 2021

Background
As the incidence of cancer is on the rise, there is a need to develop modern communication tools between patients and the medical personnel. Electronic patient-reported outcome (ePRO) measures increase the safety of cancer treatments and may have an impact on treatment outcome as well. ePRO may also provide a cost-efficient way to organize follow-up for patients with cancer. Noona is an internet-based system for patients to self-report symptoms and adverse events of cancer treatments from home via a computer or a smart device (eg, smartphone, tablet).

Objective
In this pilot study, we assessed the suitability of a novel ePRO application (Noona) for patients with cancer, nurses, and doctors at the Helsinki University Hospital, Finland.

Methods
The study included 44 patients with cancer (different solid tumor types) and 17 health care professionals (nurses or medical doctors). Patients were either operated or received systemic treatment or radiotherapy. Patients reported their symptoms to the medical staff via Noona. In addition, patients and clinicians answered a questionnaire, based on which Noona’s suitability for clinical use was evaluated in terms of usability (ease of use, operability, and learnability), reliability (subjective opinion of the participant), and incidence of harmful events reported by the participants.

Results
A total of 41/44 (93%) patients and 15/17 (88%) professionals reported that the program was easy or quite easy to use; 38/44 (86%) patients and 11/17 (65%) professionals found Noona reliable, and 38/44 (86%) patients and 10/17 (59%) professionals would recommend Noona to other patients or their colleagues. No harmful incidences caused by the use of Noona were reported by the patients; however, 1 harmful incidence was reported by one of the professionals.

Conclusions
The majority of the participants felt that Noona appeared reliable and it was easy to use. Noona seems to be a useful tool for monitoring patient’s symptoms during cancer therapy. Future studies will determine the impact of this ePRO platform in routine clinical practice.
Digital Technology Use and BMI: Evidence From a Cross-sectional Analysis of an Adolescent Cohort Study
Authors: Shen Chen , Dumontheil Iroise , Thomas Michael , Röösli Martin , Elliott Paul , Toledano Mireille 
Published: May 2021

Background
The use of digital technology such as mobile phones is ubiquitous in adolescents. However, excessive use may have adverse health effects, possibly partially mediated by disruptions to sleep.

Objective
This study aims to assess the social predictors of digital technology use and their cross-sectional association with BMI z scores and being overweight in a large sample of adolescents.

Methods
We used baseline data from a subset of a large adolescent cohort from 39 schools across Greater London who participated in the Study of Cognition, Adolescents and Mobile Phones (n=1473). Digital technology use included phone calls, internet use on mobile phones, and video gaming on any device. Multilevel regression was used to assess the associations between digital technology use and age-specific and sex-specific BMI z scores and being overweight (including obesity). Measurements were derived from height and weight, obtained by the Tanita BC-418 Body Composition Analyzer. We examined whether these associations were mediated by insufficient sleep.

Results
Generally, participants with lower socioeconomic status reported more use of digital technology. Controlling for socioeconomic status, internet use on mobile phones for more than 3 hours per day was associated with higher BMI z scores (adjusted β=.30, 95% CI 0.11-0.48) and greater odds of being overweight (adjusted odds ratio 1.60, 95% CI 1.09-2.34), compared with low use (≤30 minutes). Similar associations were found between video gaming and BMI z scores and being overweight. The BMI z score was more strongly related to weekday digital technology use (internet use on mobile phones and video gaming) than weekend use. Insufficient sleep partly mediated the associations between digital technology use and BMI z scores (proportion of mediation from 8.6% to 17.8%) by an indirect effect.

Conclusions
We found an association between digital technology use and BMI in adolescents, partly mediated by insufficient sleep, suggesting that the underlying mechanisms may be multifactorial. Further research with longitudinal data is essential to explore the direction of the relationships.
An Ostomy Self-management Telehealth Intervention for Cancer Survivors: Technology-Related Findings From a Randomized Controlled Trial
Authors: Weinstein Ronald S , Holcomb Michael J , Mo Julia , Yonsetto Peter , Bojorquez Octavio , Grant Marcia , Wendel Christopher S , Tallman Nancy J , Ercolano Elizabeth , Cidav Zuleyha , Hornbrook Mark C , Sun Virginia , McCorkle Ruth , Krouse Robert S 
Published: May 2021

Background
An Ostomy Self-management Telehealth (OSMT) intervention by nurse educators and peer ostomates can equip new ostomates with critical knowledge regarding ostomy care. A telehealth technology assessment aim was to measure telehealth engineer support requirements for telehealth technology–related (TTR) incidents encountered during OSMT intervention sessions held via a secure cloud-based videoconferencing service, Zoom for Healthcare.

Objective
This paper examines technology-related challenges, issues, and opportunities encountered in the use of telehealth in a randomized controlled trial intervention for cancer survivors living with a permanent ostomy.

Methods
The Arizona Telemedicine Program provided telehealth engineering support for 105 OSMT sessions, scheduled for 90 to 120 minutes each, over a 2-year period. The OSMT groups included up to 15 participants, comprising 4-6 ostomates, 4-6 peer ostomates, 2 nurse educators, and 1 telehealth engineer. OSMT-session TTR incidents were recorded contemporaneously in detailed notes by the research staff. TTR incidents were categorized and tallied.

Results
A total of 97.1% (102/105) OSMT sessions were completed as scheduled. In total, 3 OSMT sessions were not held owing to non–technology-related reasons. Of the 93 ostomates who participated in OSMT sessions, 80 (86%) completed their OSMT curriculum. TTR incidents occurred in 36.3% (37/102) of the completed sessions with varying disruptive impacts. No sessions were canceled or rescheduled because of TTR incidents. Disruptions from TTR incidents were minimized by following the TTR incident prevention and incident response plans.

Conclusions
Telehealth videoconferencing technology can enable ostomates to participate in ostomy self-management education by incorporating dedicated telehealth engineering support. Potentially, OSMT greatly expands the availability of ostomy self-management education for new ostomates.

Trial Registration
ClinicalTrials.gov NCT02974634; https://clinicaltrials.gov/ct2/show/NCT02974634
Audiovisual Content for a Radiology Fellowship Selection Process During the COVID-19 Pandemic: Pilot Web-Based Questionnaire Study
Authors: Godoy Ivan Rodrigues Barros , Neto Luís Pecci , Skaf Abdalla , Leão-Filho Hilton Muniz , Freddi Tomás De Andrade Lourenço , Jasinowodolinski Dany , Yamada André Fukunishi 
Published: May 2021

Background
Traditional radiology fellowships are usually 1- or 2-year clinical training programs in a specific area after completion of a 4-year residency program.

Objective
This study aimed to investigate the experience of fellowship applicants in answering radiology questions in an audiovisual format using their own smartphones after answering radiology questions in a traditional printed text format as part of the application process during the COVID-19 pandemic. We hypothesized that fellowship applicants would find that recorded audiovisual radiology content adds value to the conventional selection process, may increase engagement by using their own smartphone device, and facilitate the understanding of imaging findings of radiology-based questions, while maintaining social distancing.

Methods
One senior staff radiologist of each subspecialty prepared 4 audiovisual radiology questions for each subspecialty. We conducted a survey using web-based questionnaires for 123 fellowship applications for musculoskeletal (n=39), internal medicine (n=61), and neuroradiology (n=23) programs to evaluate the experience of using audiovisual radiology content as a substitute for the conventional text evaluation.

Results
Most of the applicants (n=122, 99%) answered positively (with responses of “agree” or “strongly agree”) that images in digital forms are of superior quality to those printed on paper. In total, 101 (82%) applicants agreed with the statement that the presentation of cases in audiovisual format facilitates the understanding of the findings. Furthermore, 81 (65%) candidates agreed or strongly agreed that answering digital forms is more practical than conventional paper forms.

Conclusions
The use of audiovisual content as part of the selection process for radiology fellowships is a new approach to evaluate the potential to enhance the applicant’s experience during this process. This technology also allows for the evaluation of candidates without the need for in-person interaction. Further studies could streamline these methods to minimize work redundancy with traditional text assessments or even evaluate the acceptance of using only audiovisual content on smartphones.
Hubungan Status ASI Eksklusif dan Pemberian Kolostrum dengan Kejadian Autisme pada Anak di Bawah 10 tahun
Authors: Khaerina Umi , Herini Siti , Ismail Djauhar 
Published: May 2021

Background: The cause of autism until now is still not exactly known. One of the efforts in preventing the occurrence of autism is intervention early with giving colostrum and exclusive breastfeeding. The number of autism in Indonesia according to data released by the Central Bureau of Statistics in 2010 was estimated at 2.4 million people. Based on data from autism special school Bina Anggita Yogyakarta, recorded increase in the number of students from the beginning of the school in 2001 were 15 students, in 2009 the number increased to 32 students and in 2013 were 45 students.Objective: To determine the relationship between the status of exclusive breastfeeding and giving colostrum to the incidence of autism in children under 10 years.Methods: This research is a quantitative study with a matched case control study design. Subjects were children aged under 10 years who consisted of children with autism were 19 cases and 19 controls for normal children in Yogyakarta. The independent variable in this study in the provision of colostrum and exclusive breastfeeding, and dependent variable was autism. The counfounding variables are gastrointestinal infections, low birth weight and maternal age. Retrieval of data collected using a questionnaire. Univariable data analysis using frequency distribution, bivariate statistics using the McNemar test, multivariable analysis was not performed because the bivariate analysis, all variables are not significantly.Results: Of the five variables that were related to the occurrence of autism, five variables are not statistically significant and two variables that increase the risk of autism gastrointestinal infection (p=0,09 OR 3,5 CI 95%; 0,66-34,53) and low birth weight (p=0,17 OR 4 CI 95%; 0,39-196,9).Conclusions: There was no significant relationship between the giving of colostrum, exclusive breastfeeding and maternal age, but clinical gastrointestinal infection and low birth weight were risk factor of autism. Keywords: Colostrum, exclusive breastfeeding, autism.
Pengaruh Sapa Orangtua Remaja Terhadap Pengetahuan, Sikap dan Perilaku Oangtua tentang Pendidikan Kesehatan Reproduksi
Authors: Widiyastuti Dyah , Nurcahyani Lia 
Published: May 2021

ABSTRAK Latar belakang : Seks pranikah merupakan masalah yang rentan terjadi pada remaja. Salah satu penyebabnya adalah kurangnya pengetahuan tentang kesehatan reproduksi. Pendidikan kesehatan reproduksi sangat penting, tetapi mayoritas orangtua memiliki pengetahuan kurang serta persepsi negatif terhadap kesehatan reproduksi remaja.Tujuan : Menganalisis perbedaan pengetahuan, sikap dan perilaku orangtua sebelum dan setelah diberikan intervensi Sapa Orangtua Remaja.Metode : Rancangan penelitian quasi experimental non randomized pre test and post test one group design. Subjek penelitian ini adalah 35 orangtua siswa Sekolah Dasar Pamitran Kota Cirebon dengan kriteria inklusi dan eksklusi. Instrumen penelitian meliputi kuesioner dan modul Sapa Orang Tua Remaja . Analisis data menggunakan uji wilcoxon dan paired t-test.Hasil dan pembahasan : Terdapat perbedaan yang bermakna pengetahuan sikap dan perilaku orang tua sebelum dan setelah intervensi (p value 0,003 ; 0,000 dan 0,013).Kesimpulan : Sapa orangtua remaja dapat meningkatkan pengetahuan, sikap dan perilaku orangtua tentang kesehatan reproduksi remaja.
Perbandingan Angka Ketahanan Hidup Penderita Kanker Ovarium yang Mendapat Terapi Regimen Kemoterapi Paclitaxel-Carboplatin dan Vyclophosphamide-Adriamycin-Cisplatin di RSUP Dr. Sardjito: Studi retrospektif Januari 2014-Desember 2018
Authors: Novitasari Choery , Attamimi Ahsanuddin , Pradjatmo Heru 
Published: May 2021

Latar Belakang: Kanker merupakan penyebab kematian kedua terbanyak setelah penyakit kardiovaskular dan lebih dari 70% kematian yang disebabkan oleh kanker terjadi di negara berkembang. Kanker ovarium merupakan kanker terbanyak kesembilan pada wanita dan menjadi kanker dengan mortalitas ke-5 terbanyak, yaitu 8,6 per 100.000.Tujuan: Menilai angka ketahanan hidup penderita kanker ovarium yang diberikan kemoterapi dengan regimen Paclitaxel- Carboplatin dibandingkan dengan regimen Cyclophospamide-Adriamicyn-Cisplatin di RSUP Sardjito.Metode: Penelitian ini merupakan penelitian observasional dengan rancangan studi analisis angka ketahanan hidup (survival rate) dari penderita kanker ovarium. Data akan diambil secara retrospektif dari rekam medis pasien kanker ovarium yang berobat ke RSUP dr. Sardjito kemudian ditelusuri riwayat kematiannya.Hasil dan Pembahasan: Terdapat 353 penderita kanker ovarium yang dilakukan kemoterapi, terdiri dari 265 subjek yang diterapi PC dan 88 subjek yang diterapi dengan CAP. Dari analisis bivariat didapatkan bahwa regimen kemoterapi PC dan CAP tidak memengaruhi angka ketahanan hidup (HR=1,15, p=0,64, CI95%=0,64-2,05).Usia <50 tahun (HR=0,42, p=0,01, CI95%=0,23-0,77), stadium klinis awal (HR=0,27, p=0,00, CI95%=0,14-0,49), dan CA125 pasca kemoterapi <70 U/mL (HR=0,21, p=0,00, CI95%=0,11-0,41) merupakan faktor protektif terhadap angka ketahanan hidup penderita kanker ovarium. Analisis multivariat dengan angka ketahanan hidup (cox’s regression) menunjukkan bahwa faktor yang dapat meningkatkan angka ketahanan hidup adalah stadium klinis awal (HR=0,45, p=0,04, CI95%=0,18-0,91) dan CA125 pasca kemoterapi (HR=0,33, p=0,01, CI95%=0,15-0,74).Kesimpulan: Tidak ada perbedaan bermakna antara regimen kemoterapi PC dan CAP dengan angka ketahanan hidup penderita kanker ovarium yang dirawat di RSUP dr. Sardjito selama tahun 2014-2018. Faktor- faktor yang dapat meningkatkan angka ketahanan hidup pasien kanker ovarium adalah stadium klinis awal dan CA125 pasca kemoterapi <70 U/mL. Kata Kunci: Angka ketahanan hidup; kanker ovarium; regimen paclitaxel dan carboplatin; regimen cyclophosphamide, adriamycin, cisplatin
Analisis Rugi-Rugi (Losses) Transformator Daya 150/20 KV di PT. PLN (Persero) Gardu Induk Sutami ULTG Tarahan
Authors: Elnizar Hendri , Gusmedi Herri , Zebua Osea 
Published: May 2021

In general, in the distribution of electrical energy, there will always be losses. In a transformer, there are two types of losses, namely technical losses and non-technical losses. Non-technical losses are caused by things outside of system performance, such as accidents, natural disasters, human negligence, and so on. Meanwhile, technical losses are caused by two things, namely copper losses and core losses. Technical losses in the transformer cause the efficiency of the electricity supply to be low. Therefore the author will make a thesis entitled "Analysis of Losses Power Transformer 150/20 KV in PT PLN (PERSERO) Substation Sutami ULTG Tarahan" The analysis was carried out in July 2019, which aims to determine the amount of losses - losses on the transformer every day within a month, as well as calculating the percentage increase in losses due to changes in normal load current to peak load current. The calculation results show that the highest Losses on Transformer 1 falls on July 23, 2019, amounting to 4,588,204 kw. The highest loss on Transformer 2 falls on July 11, 2019, amounting to 16,246,884 kw. Then the magnitude of the change in the increase in current from normal load current to peak load current on Transformer 1, will cause losses to increase by 3.66%, and the amount of change in the increase in current from normal load current to peak load current on Transformer 2, will cause losses to increase by 2,38%.
Keywords: Transformer, losses, copper losses, core losses
GIS-Based Area Suitability Analysis for Development Planning Purposes Campus: Case Study Banyuwangi State Polytechnic
Authors: Farisqi Panduardi Endi Sailul Haq, 
Published: May 2021

In the context of the ecological relationship between humans and the academic environment, success in obtaining high-quality graduations influenced by the quality of the building's space system and other supporting facilities as a place for students to study. So the construction site's design becomes an essential factor to consider in the educational environment. Banyuwangi state polytechnic has not implemented and developed SIG to determine the construction site. Hence, it causes campus spatial planning problems for the future, like puddles, floods, noisy classrooms, and difficult access to each building. Banyuwangi State Polytechnic, as a twelve-year-old college in Banyuwangi, is in desperate need of regional development planning as one of the efforts to ensure the continuity of academic activities that are adequate and comfortable for students. This study aims to ?nd out the area suitability for determining Banyuwangi State Polytechnic development's best location choice. Banyuwangi State Polytechnic, located in the middle of the public road on the east side and the railway in the west to the north, causes noise levels to be a critical issue to consider to achieve a fair learning process. Area suitability assessment is a critical determinant in campus planning development. The suitability assessment is carried out through the AHP (analytical hierarchy process) model covering all land, buildings, noise levels, soil slope, road access, and availability of irrigation channels. The data obtained mapped into the Geographic Information System using Quantum GIS (QGIS) software. Land-use suitability is calculated based on criteria in the form of noise level (NL), land elevation (EL), ease of access (RA), and irrigation channel (ICA). There are 4 points obtained after discussions with the development planning unit management for alternative locations for development sites. The highest weight of the best criteria for determining location is the NL criteria of 0.566 and PSI of 0.283. The best location for development is in the second alternative location with a weight of 0,20176, followed by the third alternative location with a weight of 0,12028.
The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
Authors: Nocheva H. , Sabit Z. , Grigorov E. 
Published: May 2021

Abstract
Stress-induced analgesia (SIA) is a well-known phenomenon, in which mechanisms of development opioid and non-opioid components take part. The endogenous cannabinoid system (ECS) takes part in the non-opioid pathways and modulates nociception. Nitric oxide (NO) is also proverbial to interfere with pain perception. The present study was performed to investigate the effects from interaction between the ECS and NO after heat (heat stress) or cold (cold stress) exposure. Male Wistar rats subjected to one hour of heat or cold stress were injected with different combinations of cannabinoid receptor type 1 (CB1) agonist anandamide (AEA) or antagonist (AM251) along with NO-donor, NO-precursor or inhibitor of the NO-synthase (NOS). Nociception was evaluated using Paw pressure (Randall-Selitto) test. The results showed that AEA-administration immediately after the end of stress let to a tendency to increase cold-SIA, but decreased heat-SIA. AEA along with NO-donor increased both cold- and heat-SIA but to a different degree. AM251 and NOS-inhibitor decreased SIA. Our experiments confirmed that the endogenous cannabinoid and the nitricoxidergic systems interact between them in the modulation of SIA. The ECS exerts a more prominent influence on cold rather than heat SIA. Differences in modulation probably depend on the type of stress, due to the different participation of ECS in the mechanisms of SIA development.
Physicochemical Research of Clinically Retrieved CU-NI-TI Orthodontic Archwires
Authors: Stoyanova-Ivanova A. , Petrov V. , Petrova V. , Andreeva L. , Ilievska I. , Zaleski A. , Mikli V. 
Published: May 2021

Abstract
In modern orthodontics, thermally activated archwires are used more widely in clinical practice, because they have unique properties like superelasticity and bio-compatibility. The aim of the present study was to characterize commercial 35° C Cu-NiTi archwires in terms of their phase transition behavior, chemical composition, surface topography properties after clinical usage, as well as the influence of the autoclaving process. Materials and methods. 35° C Thermo-Active Copper NiTi (CuNiTi) of ORMCO, Glendora, CA, USA (as-received, as-received autoclaved and clinically retrieved) with rectangular cross-section and dimension 0.016x0.022 inch, were investigated. The physicochemical research was conducted via Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDX) and X-ray Diffraction Analysis (XRD). The autoclaving was done in Runyes model B autoclave. Results. The DSC results revealed the austenite start (9.8° C; 26.47° C) and austenite finish (28° C; 31.74° C) temperatures for the as-received and autoclaved archwires respectively. For clinically retrieved samples the austenite finish temperature (Af) is around 27° C. The XRD patterns of the as-received and clinically retrieved samples show almost identical diffraction patterns. Rough surface of the CuNiTi alloy was revealed by the SEM analysis. Autoclaving process seems to have no effects on archwires’ structure and chemical composition. Chemical content of the investigated as-received CuNiTi are Ni, Ti and Cu: 47.07 wt% and 46.81 wt% and 6.11 wt%, respectively. The autoclaving process seems to have little influence on the transition temperature. The results from our study showed little difference (~7 °C) in the finish transition temperatures (Af), compared to the manufacturer’s claim. No intermediate R phase was detected by DSC. Conclusion. A good knowledge of the structural changes that occur in CuNiTi alloys in the oral cavity is useful for the orthodontists in order to optimize orthodontic treatment.