bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and clinical applicability of a novel tear film imaging tool
Authors: Tóth Noémi , Szalai Eszter , Rák Tibor , Lillik Veronika , Nagy Attila , Csutak Adrienne 
Published: March 2021

Abstract
Purpose
The aim of our research was to investigate the reliability and clinical applicability of a modern tear film imaging tool by comparing the inter- and intragrader difference. The further goal was to compare the non-invasive tear break-up time (NIBUT) measured with the LacryDiag® device with traditional tear film break-up time (TBUT).

Methods
Comprehensive ophthalmological examination was performed, including LacryDiag® (Quantel Medical, France) (lower tear meniscus height measuring (LTMH), superior and inferior eyelid meibography (MeibS MeibI), interferometry (INT), NIBUT), slit lamp examination, and TBUT. Two independent, well-trained graders selected and analyzed the LTMH, MeibI, MeibS, and INT. The second grader reanalyzed the data 1 month later. Intra- and inter-examiner reliabilities were evaluated using intraclass correlation coefficients (ICC), while for categorical variable, Cohen’s kappa statistics were provided. The Bland-Altman plot was used for visualization of the agreement between measurements.

Results
Fifty healthy volunteers were examined. For LTMH both the inter- and intragrader variabilities were excellent. Between two graders, the ICC of MeibI was poor; however, between two graders, the ICC of MeibS was good, and the intragrader variability in MeibI and MeibS was excellent. For the INT, both intra- and intergrading were in fair and moderate agreement, although the intragrader agreement was higher. Comparing the NIBUT and TBUT, the agreement was slight.

Conclusion
Based on our results, examination of a patient during follow-up should be performed by the same examiner, because of the slight agreement. The LacryDiag® is a non-invasive, easy-to-use device, which can examine the tear film and save the recordings for easier follow-up.
Gender composition in occupations and branches and medically certified sick leave: a prospective population study
Authors: Lidwall Ulrik 
Published: March 2021

Abstract
Objective
To investigate whether gender-segregated occupations and branches are associated with future medically certified sick leave for women and men.

Methods
All gainfully employed residents in Sweden in December 31st 2014 aged 16–69 years (n = 4 473 964) were identified in national registers. Subjects working in segregated (61–90%) and extremely segregated (> 90%) occupations and branches were evaluated v/s subjects in gender-integrated occupations and branches (40–60%). Combinations of segregation by occupation and branch were also investigated. Two-year prospective medically certified sick leaves (> 14 days) were evaluated using logistic regression with odds ratios recalculated to relative risks (RR), adjusted for work, demographic and health related factors.

Results
The sick leave risk was higher for those working in extremely female-dominated occupations (women RR 1.06 and men RR 1.13), and in extremely female-dominated branches (women RR 1.09 and men RR 1.12), and for men in extremely male-dominated branches (RR 1.04). The sick leave risk was also higher for both women and men in female-dominated occupations regardless of the gender segregation in the branch they were working in. However, the differences in sick leave risks associated with gender segregation were considerably smaller than the differences between occupations and branches in general.

Conclusions
Gender segregation in occupations and branches play a role for sick leave among women and men, especially within extremely female-dominated occupations and branches. However, gender segregation appears to be subordinate to particular occupational hazards faced in diverse occupations and branches.
From dyad to triad: a survey on fathers’ knowledge and attitudes toward breastfeeding
Authors: Crippa Beatrice Letizia , Consales Alessandra , Morniroli Daniela , Lunetto Flavia , Bettinelli Maria Enrica , Sannino Patrizio , Rampini Serena , Zanotta Lidia , Marchisio Paola , Plevani Laura , Giannì Maria Lorella , Mosca Fabio , Colombo Lorenzo 
Published: March 2021

AbstractFathers are known to impact breastfeeding outcomes. We aimed to explore paternal knowledge and attitude toward breastfeeding, and possible association with breastfeeding rates at discharge. In this cross-sectional study, we enrolled 200 fathers of healthy term neonates. At discharge, fathers were asked to rate their degree of agreement to 12 items on a 5-point Likert scale. A total score was obtained from their answers. Univariate binary logistic regression analysis was used to verify if the total score was predictive of exclusive breastfeeding at discharge. A multivariable logistic regression model was then used to adjust for possible confounders. ROC analysis was performed, and a Youden’s total score cut-off value was determined to define total score’s performance in predicting exclusive breastfeeding at discharge. Fathers showed a solid knowledge of maternal (87%) and neonatal (98%) benefits of breastfeeding, skin-to-skin (99.5%), rooming-in (79%), and responsive feeding (67.5%); conversely, only 51% knew about the recommended use of pacifiers. Fathers felt personally involved in babies’ feeding in 79% of cases. An association was found between total score and exclusive breastfeeding at discharge at univariate (OR: 1.07, p = 0.04) but not at multivariable analysis (OR: 1.07, p = 0.067). ROC analysis was not statistically significant (AUC 0.58, p = 0.083).Conclusion: By using a novel instrument aimed at quantifying fathers’ knowledge and overall attitude toward breastfeeding, this study underlines the importance of including fathers in the promotion of breastfeeding. Expanding the classic mother-baby dyad to a more modern mother-father-baby triad may impact breastfeeding outcomes at discharge.

What is known:• Social support plays a major role in improving breastfeeding outcomes.• Fathers may greatly influence initiation and duration of breastfeeding; the more they know, the more helpful they can be.What is new:• A multidisciplinary team created a structured questionnaire aimed at quantifying fathers’ knowledge and attitude toward breastfeeding.• The association between a higher questionnaire total score and exclusive breastfeeding rates at discharge highlights the importance of including fathers in the promotion of breastfeeding, as part of the breastfeeding team.
Mapping and anatomo-surgical techniques for SMA-cingulum-corpus callosum gliomas; how I do it
Authors: Klitsinikos Dimitris , Ekert Justyna O. , Carels Annefloor , Samandouras George 
Published: March 2021

Abstract
Background
Awake brain mapping paradigms are variable, particularly in SMA, and not personalised to each patient. In addition, subpial resections do not offer full protection to vascular injury, as the pia can be easily violated.

Methods
Mapping paradigms developed by a multidisciplinary brain mapping team. During resection, a combined subpial/interhemispheric approach allowed early identification and arterial skeletonization. Precise anatomo-surgical dissection of the affected cingulum and corpus callosum was achieved.

Conclusions
In SMA-cingulum-CC tumours, a combined subpial/interhemispheric approach reduces risk of vascular injury allowing precise anatomo-surgical dissections. Knowledge of cognitive functions of affected parcels is likely to offer best outcomes.
How is neck dissection performed in Oral and Maxillofacial Surgery? Results of a representative nationwide survey among university and non-university hospitals in Germany
Authors: Pabst Andreas , Thiem Daniel G. E. , Goetze Elisabeth , Bartella Alexander K. , Neuhaus Michael T. , Hoffmann Jürgen , Zeller Alexander-N. 
Published: March 2021

Abstract
Introduction
Neck dissection (ND) is a surgical procedure addressing cervical lymph nodes and metastases in patients with oral squamous cell carcinoma (OSCC). The aim of this study was to analyze clinical decisions regarding indications and variations of ND in Oral and Maxillofacial Surgery (OMFS) in Germany.

Material and methods
A nationwide survey of the German Association of Oral and Maxillofacial Surgery was performed using dynamic online questionnaires including 38 questions. Data about oncological centers, case numbers, and staging procedures were collected. Relevant aspects, such as inclusion of level IIb and levels IV and V to ND, uni- vs. bilateral ND, and the influence of extra-nodal extension (ENE) of metastases on extension of ND were evaluated.

Results
Eighty-four OMFS of university and non-university hospitals participated in the study (responding rate 21.4%). Sixty-six (78.57%) stated to work at certified cancer centers and 53.57% of the hospitals treated between 50 and 100 OSCC cases per year. CT and/or MRI of the head and neck was performed in most of the staging procedures. Level IIb was included by 71 (93.42%) of the participants in selective ND. Levels IV and V were included by 53 (69.74%) in node-positive neck. In solitary ipsilateral metastases (ENE−), 49 participants (62.82%) stated to perform exclusively an ipsilateral ND and 40 (51.95%) stated to perform only an ipsilateral ND in ENE+.

Conclusion
This study demonstrated a high rate of certified cancer centers in Germany showing differences regarding staging procedures, indications, and extension of ND, especially in increasingly complex cases.

Clinical relevance
Clinical decisions regarding ND are dependent on case-individual aspects and must be decided individually.
Relationship of the vascular territory affected by delayed cerebral ischemia and the location of the ruptured aneurysm in patients with aneurysmal subarachnoid hemorrhage
Authors: Hurth Helene , Steiner Jochen , Birkenhauer Ulrich , Roder Constantin , Hauser Till-Karsten , Ernemann Ulrike , Tatagiba Marcos , Ebner Florian Heinrich 
Published: March 2021

Abstract
Objective
To determine the area most at risk of delayed cerebral ischemia (DCI) in relation to the location of the ruptured aneurysm in patients with aneurysmal subarachnoid hemorrhage (aSAH) and, therefore, help to choose the site for focal multimodal neuromonitoring.

Methods
We retrospectively analyzed angiographic findings, CCT scans, and patient charts of patients who were admitted with aSAH to our neurosurgical intensive care unit between 2009 and 2017. DCI was defined as infarction on CCT 2–6 weeks after aSAH.

Results
DCI occurred in 17.9% out of 357 included patients. A DCI occurring in the vascular territory of the artery carrying the ruptured aneurysm was found in 81.0% of patients with anterior circulation aneurysms but only in 16.7% with posterior circulation aneurysms (Fisher’s exact, p=0.003). The vascular territory most frequently showing a DCI was the ipsilateral MCA territory (86.7%) in ICA aneurysms, the contra- (71.4%) and the ipsilateral (64.3%) ACA territory in ACA aneurysms, the right (93.8%) and the left (81.3%) ACA territory in AcomA aneurysms, and the ipsilateral MCA territory in MCA aneurysms (69.2%) as well as in VA/PICA/SCA aneurysms (100.0%). DCI after the rupture of a BA aneurysm occurred with 33.3% in 6 out of 8 vascular territories, respectively. DCI of multiple vascular territories occurred in 100.0% of BA aneurysms, 87.5% of AcomA aneurysms, 71.4% of ACA aneurysms, 40.0% of ICA aneurysms, 38.5% of MCA aneurysms, and 33.3% of VA/PICA/SCA aneurysms.

Discussion
Few studies exist that could determine the area most at risk of a DCI after an aSAH. Our data could identify the territory most at risk for DCI with a probability of > 60% except for BA aneurysms, which showed DCI in various areas and patients suffering from multiple DCIs. Either the ipsilateral ACA or MCA were affected by the DCI in about 80% of ACA and more than 90% of AcomA, ICA, MCA, and VA/PICA/SCA aneurysms. Therefore, local intraparenchymal neuromonitoring in the ACA/MCA watershed area might detect the vast majority of DCIs for all aneurysm locations, except for BA aneurysms. In ACA and AcomA aneurysms, bilateral DCI of the ACA territory was common, and bilateral probe positioning might be considered for monitoring high-risk patients. Non-focal monitoring methods might be preferably used after BA aneurysm rupture.
Rationale and Design of the ADIDAS Study: Association Between Dapagliflozin-Induced Improvement and Anemia in Heart Failure Patients
Authors: Zeng Jianping , Zhu Yunlong , Zhao Wenjiao , Wu Mingxing , Huang Haobo , Huang He , Wu ChunFeng , Zhou XiaoLin , Zhou ShengHua , Wang ChengMing , Yin Kai , Xu FangHua , Cai ZhiQiang , Li Xinyang , Cheng Huiheng , Xie Youwen , Tan Zhuqing , Hu Xiaoyong , Liao Dexiang , Wang Yingchun 
Published: March 2021

Abstract
Background
Heart failure (HF) is one of the most serious health concerns worldwide. Anemia is a highly prevalent comorbidity and outcome predictor in HF patients. Sodium glucose co-transport 2 (SGLT2) inhibitors have been demonstrated to reduce the risk of cardiovascular death and HF hospitalization in HF patients.

Purpose
This investigator-initiated, interventional, prospective, double-blind, multicenter study is designed to investigate whether anemia correction is one of the prerequisites and determinants related to the beneficial effects of dapagliflozin in HF patients.

Methods and Results
Up to 2030 HF participants receiving standard care will be randomly assigned to either oral dapagliflozin 10 mg once daily or placebo 10 mg once daily for 12 months. The primary outcome is the composite incidence of hospital admission for HF and all-cause death. Secondary outcomes include change in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score and change in 6-min walk distance and hemoglobin level. Patients will be followed for 12 months after randomization.

Conclusions
The ADIDAS trial offers an opportunity to assess the hemoglobin change and association between hemoglobin change and readmissions due to heart failure and all-cause death in patients with heart failure treated with dapagliflozin or placebo. This study could highlight if dynamic hemoglobin change is related to the outcome for HF patients.

Trial Registration
ClinicalTrials.gov; NCT04707261. Registration date, 2020/12/01, “retrospectively registered”
Revisiting the VCCFinder approach for the identification of vulnerability-contributing commits
Authors: Riom Timothé , Sawadogo Arthur , Allix Kevin , Bissyandé Tegawendé F. , Moha Naouel , Klein Jacques 
Published: March 2021

AbstractDetecting vulnerabilities in software is a constant race between development teams and potential attackers. While many static and dynamic approaches have focused on regularly analyzing the software in its entirety, a recent research direction has focused on the analysis of changes that are applied to the code. VCCFinder is a seminal approach in the literature that builds on machine learning to automatically detect whether an incoming commit will introduce some vulnerabilities. Given the influence of VCCFinder in the literature, we undertake an investigation into its performance as a state-of-the-art system. To that end, we propose to attempt a replication study on the VCCFinder supervised learning approach. The insights of our failure to replicate the results reported in the original publication informed the design of a new approach to identify vulnerability-contributing commits based on a semi-supervised learning technique with an alternate feature set. We provide all artefacts and a clear description of this approach as a new reproducible baseline for advancing research on machine learning-based identification of vulnerability-introducing commits.
Evolutionary trends of the genus Ancyrogondolella (Conodonta) and related taxa in the Norian (Late Triassic)
Authors: Karádi Viktor 
Published: March 2021

AbstractThe Norian represents the longest stage of the Triassic, nevertheless, its precise subdivision is an unresolved matter. Conodonts might be useful in the establishment of an accurate biozonation to avoid common scientific misinterpretations. Understanding the Norian evolutionary trends and morphological changes of theAncyrogondolellalineage (genusAncyrogondolellaand descendant generaEpigondolella, OrchardellaandMockina) is of key importance in this issue. The forward shifting of the pit and the posterior prolongation of the keel and the carina characterize the main trend that corresponds to the faunal turnover around the Lacian-Alaunian transition. A gradual decrease in overall element width and length can be observed from that time on, which couples with a decrease in the length of the free blade and an increase in the height of the anterior platform denticles. The presence of secondary carinae is characteristic for the mid-Lacian 1 to Alaunian 1, but their development shows no trends and has no taxonomic value. Adult specimens of the Lacian generally have an arched lower profile, whereas in the Alaunian and Sevatian the lower profile is dominantly stepped or straight. The thorough documentation of the Tethyan assemblages is needed for any detailed taxonomic and paleobiogeographic comparisons with other regions.
Combined cervicosternotomy and cervicotomy for true retrosternal goiters: a surgical cohort study
Authors: Van Slycke S. , Simons A.-S. , Van Den Heede K. , Van Crombrugge P. , Tournoy K. , Simons P. , Vermeersch H. , Brusselaers N. 
Published: March 2021

Abstract
Objective
Intrathoracic goiters are a heterogeneous group characterized by limited or extensive substernal extension. Whereas the former can be treated through cervicotomy, the latter sometimes requires a cervicosternotomy. Whether cervicosternotomy leads to more morbidity remains unclear.
This study aimed to compare intra- and postoperative morbidity in patients treated by cervicotomy or cervicosternotomy for intrathoracic goiters and standard thyroidectomy.

Methods
In a prospectively gathered cohort undergoing thyroid surgery (2010–2019) intra- and postoperative morbidity of cervicotomy (N = 80) and cervicosternotomy (N = 15) for intrathoracic goiters was compared to each other and to a ‘standard’ thyroidectomy (N = 1500).

Results
An intrathoracic extension prior to surgery was found in 95 (6%) of all thyroidectomies. Eighty patients (84%) were operated by cervicotomy and 15 (16%) by cervicosternotomy. The risk of temporary recurrent laryngeal nerve palsy was much higher in the cervicosternotomy group (21%) compared to cervicotomy (4%) and standard thyroidectomy (3%). The risk of temporary hypocalcemia after cervicotomy (28%) was comparable to a standard thyroidectomy (32%) but higher after cervicosternotomy (20%). No cases of permanent hypocalcemia or laryngeal nerve palsy were observed in both groups with substernal extension. The need for surgical reintervention was significantly higher in the cervicotomy group (6%) compared to cervicosternotomy (0%) and standard thyroidectomy (3%).

Conclusion
In patients undergoing thyroid surgery for an intrathoracic goiter, cervicosternotomy was associated with more temporary laryngeal nerve palsy, but none of the interventions resulted in higher risks of permanent nerve damage, permanent hypocalcemia, or reintervention for bleeding. Reintervention was even more common after cervicotomy compared to cervicosternotomy.

Level of evidence
IV
Bad projections of the PSD cone
Authors: Jiang Yuhan , Sturmfels Bernd 
Published: March 2021

AbstractThe image of the cone of positive semidefinite matrices under a linear map is a convex cone. Pataki characterized the set of linear maps for which that image is not closed. The Zariski closure of this set is a hypersurface in the Grassmannian. Its components are the coisotropic hypersurfaces of symmetric determinantal varieties. We develop the convex algebraic geometry of such bad projections, with focus on explicit computations.
Autism, Problematic Internet Use and Gaming Disorder: A Systematic Review
Authors: Murray Alayna , Koronczai Beatrix , Király Orsolya , Griffiths Mark D. , Mannion Arlene , Leader Geraldine , Demetrovics Zsolt 
Published: March 2021

AbstractThe present study investigated the association between autism and problematic internet use (PIU) and gaming disorder (GD). A systematic literature search was conducted in accordance with PRISMA guidelines. A total of 2286 publications were screened, and 21 were deemed eligible for inclusion in the review. The majority of the studies found positive associations between PIU and subclinical autistic-like traits with weak and moderate effect sizes and between PIU and Autism Spectrum Disorder (ASD) with varying effect sizes. Additionally, individuals with ASD were more likely to exhibit symptoms of GD with moderate and strong effect sizes. Future research would benefit from high-quality studies examining GD and PIU at a clinical level and their relationship with both clinical and subclinical autism.
Review on ranking and selection: A new perspective
Authors: Hong L. Jeff , Fan Weiwei , Luo Jun 
Published: March 2021

AbstractIn this paper, we briefly review the development of ranking and selection (R&S) in the past 70 years, especially the theoretical achievements and practical applications in the past 20 years. Different from the frequentist and Bayesian classifications adopted by Kim and Nelson (2006b) and Chick (2006) in their review articles, we categorize existing R&S procedures into fixed-precision and fixed-budget procedures, as in Hunter and Nelson (2017). We show that these two categories of procedures essentially differ in the underlying methodological formulations, i.e., they are built on hypothesis testing and dynamic programming, respectively. In light of this variation, we review in detail some well-known procedures in the literature and show how they fit into these two formulations. In addition, we discuss the use of R&S procedures in solving various practical problems and propose what we think are the important research questions in the field.
Cellular Automata-based computational library for development of digital material representation models of heterogenous microstructures
Authors: Boguń Konrad , Sitko Mateusz , Mojżeszko Mateusz , Madej Łukasz 
Published: March 2021

Abstract
The development of an efficient numerical approach for the generation of a wide range of heterogeneous microstructures models with the application of the lean workflow concept is presented in the paper. First, the idea and implementation details of the developed cellular automata-based computational library allowing the development of digital material representation models within a workflow are presented in the paper. Such an approach provides the desired flexibility in the generation of various digital models of heterogenous microstructures. Therefore, the proposed library is mostly implemented within the object-oriented C + + programming language with the assumption of modularity. In this case, the main part of the application consists of classes and methods, which can be treated like base elements to be inherited and extended in other libraries. Each additional dynamic link library implements particular algorithms for the generation of specific microstructure features in the digital model within the unified data structures that allow the application of the workflow concept. The set of developed libraries and their assumptions are described as case studies to show the capabilities of the presented solution. Finally, examples of practical applications of the developed library in the full-field numerical simulations of complex material deformation are presented at the end of the paper.