bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-top final states as a probe of top-flavoured dark matter models at the LHC
Authors: Blanke Monika , Pani Priscilla , Polesello Giacomo , Rovelli Giulia 
Published: January 2021

Abstract
Models incorporating flavoured dark matter provide an elegant solution to the dark matter problem, evading the tight LHC and direct direction constraints on simple WIMP models. In Dark Minimal Flavour Violation, a simple framework of flavoured dark matter with new sources of flavour violation, the constraints from thermal freeze-out, direct detection experiments, and flavour physics create well-defined benchmark scenarios for these models. We study the LHC phenomenology of four such scenarios, focusing on final states where a single top quark is produced accompanied by no jets, one jet from the fragmentation of light quarks or a b-tagged jet. For each of these signatures we develop a realistic LHC analysis, and we show that the proposed analyses would increase the parameter space coverage for the four benchmarks, compared to existing flavour-conserving LHC analyses. Finally we show the projected discovery potential of the considered signatures for the full LHC statistics at 14 TeV, and for the High Luminosity LHC.
T
3-invariant heterotic Hull-Strominger solutions
Authors: Acharya Bobby Samir , Kinsella Alex , Svanes Eirik Eik 
Published: January 2021

Abstract
We consider the heterotic string on Calabi-Yau manifolds admitting a Strominger-Yau-Zaslow fibration. Upon reducing the system in the T3-directions, the Hermitian Yang-Mills conditions can then be reinterpreted as a complex flat connection on ℝ3 satisfying a certain co-closure condition. We give a number of abelian and non-abelian examples, and also compute the back-reaction on the geometry through the non-trivial α′-corrected heterotic Bianchi identity, which includes an important correction to the equations for the complex flat connection. These are all new local solutions to the Hull-Strominger system on T3× ℝ3. We also propose a method for computing the spectrum of certain non-abelian models, in close analogy with the Morse-Witten complex of the abelian models.
Moderate hypofractionation remains the standard of care for whole-breast radiotherapy in breast cancer: Considerations regarding FAST and FAST-Forward
Authors:   Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO), Krug David , Baumann René , Combs Stephanie E. , Duma Marciana Nona , Dunst Jürgen , Feyer Petra , Fietkau Rainer , Haase Wulf , Harms Wolfgang , Hehr Thomas , Piroth Marc D. , Sedlmayer Felix , Souchon Rainer , Strnad Vratislav , Budach Wilfried 
Published: January 2021

AbstractModerate hypofractionation is the standard of care for adjuvant whole-breast radiotherapy after breast-conserving surgery for breast cancer. Recently, 10-year results from the FAST and 5‑year results from the FAST-Forward trial evaluating adjuvant whole-breast radiotherapy in 5 fractions over 5 weeks or 1 week have been published. This article summarizes recent data for moderate hypofractionation and results from the FAST and FAST-Forward trial on ultra-hypofractionation. While the FAST trial was not powered for comparison of local recurrence rates, FAST-Forward demonstrated non-inferiority for two ultra-hypofractionated regimens in terms of local control. In both trials, the higher-dose experimental arms resulted in elevated rates of late toxicity. For the lower dose experimental arms of 28.5 Gy over 5 weeks and 26 Gy over 1 week, moderate or marked late effects were similar in the majority of documented items compared to the respective standard arms, but significantly worse in some subdomains. The difference between the standard arm and the 26 Gy of the FAST-Forward trial concerning moderate or marked late effects increased with longer follow-up in disadvantage of the experimental arm for most items. For now, moderate hypofractionation with 40–42.5 Gy over 15–16 fractions remains the standard of care for the majority of patients with breast cancer who undergo whole-breast radiotherapy without regional nodal irradiation after breast-conserving surgery.
Künstliche Intelligenz in der Mammadiagnostik
Authors: Baltzer Pascal A. T. 
Published: January 2021

ZusammenfassungKlinisches/methodisches ProblemBei der Mammadiagnostik gilt es, klinische sowie multimodal bildgebende Informationen mit perkutanen und operativen Eingriffen zu koordinieren. Aus dieser Komplexität entsteht eine Reihe von Problemen: übersehene Karzinome, Überdiagnose, falsch-positive Befunde, unnötige weiterführende Bildgebung, Biopsien und Operationen.Radiologische StandardverfahrenFolgende Untersuchungsverfahren werden in der Mammadiagnostik eingesetzt: Röntgenmammographie, Tomosynthese, kontrastangehobene Mammographie, (multiparametrischer) Ultraschall, Magnetresonanztomographie, Computertomographie, nuklearmedizinische Verfahren sowie deren Hybridvarianten.Methodische InnovationenKünstliche Intelligenz (KI) verspricht Abhilfe bei praktisch allen Problemen der Mammadiagnostik. Potenziell lassen sich Fehlbefunde vermeiden, bildgebende Verfahren effizienter einsetzen und möglicherweise auch biologische Phänotypen von Mammakarzinomen definieren.LeistungsfähigkeitAuf KI basierende Software wird für zahlreiche Anwendungen entwickelt. Am weitesten fortgeschritten sind Systeme für das Screening mittels Mammographie. Probleme sind monozentrische sowie kurzfristig am finanziellen Erfolg orientierte Ansätze.BewertungKünstliche Intelligenz (KI) verspricht eine Verbesserung der Mammadiagnostik. Durch die Vereinfachung von Abläufen, die Reduktion monotoner und ergebnisloser Tätigkeiten und den Hinweis auf mögliche Fehler ist eine Beschleunigung von dann weitgehend fehlerfreien Abläufen denkbar.Empfehlung für die PraxisIn diesem Beitrag werden die Anforderungen der Mammadiagnostik und mögliche Einsatzgebiete der der KI beleuchtet. Je nach Definition gibt es bereits praktisch anwendbare Softwaretools für die Mammadiagnostik. Globale Lösungen stehen allerdings noch aus.
The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals
Authors: Marchetti Francesco , Zhou Gu , LeBlanc Danielle , White Paul A. , Williams Andrew , Yauk Carole L. , Douglas George R. 
Published: January 2021

AbstractThe Organisation for Economic Co-Operation and Development Test Guideline 488 (TG 488) uses transgenic rodent models to generate in vivo mutagenesis data for regulatory submission. The recommended design in TG 488, 28 consecutive daily exposures with tissue sampling three days later (28 + 3d), is optimized for rapidly proliferating tissues such as bone marrow (BM). A sampling time of 28 days (28 + 28d) is considered more appropriate for slowly proliferating tissues (e.g., liver) and male germ cells. We evaluated the impact of the sampling time on mutant frequencies (MF) in the BM of MutaMouse males exposed for 28 days to benzo[a]pyrene (BaP), procarbazine (PRC), isopropyl methanesulfonate (iPMS), or triethylenemelamine (TEM) in dose–response studies. BM samples were collected + 3d, + 28d, + 42d or + 70d post exposure and MF quantified using the lacZ assay. All chemicals significantly increased MF with maximum fold increases at 28 + 3d of 162.9, 6.6, 4.7 and 2.8 for BaP, PRC, iPMS and TEM, respectively. MF were relatively stable over the time period investigated, although they were significantly increased only at 28 + 3d and 28 + 28d for TEM. Benchmark dose (BMD) modelling generated overlapping BMD confidence intervals among the four sampling times for each chemical. These results demonstrate that the sampling time does not affect the detection of mutations for strong mutagens. However, for mutagens that produce small increases in MF, sampling times greater than 28 days may produce false-negative results. Thus, the 28 + 28d protocol represents a unifying protocol for simultaneously assessing mutations in rapidly and slowly proliferating somatic tissues and male germ cells.
Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis
Authors: Traxel Sabrina , Lehmann Julia , Richard Stefanie , Sidorov Semjon , Niggli Felix , Berger Christoph , Nadal David , Bürgler Simone 
Published: January 2021

AbstractB-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy. The two-step BCP-ALL pathogenesis requires in utero-induced chromosomal aberrations and additional mutagenic events for overt leukemia. In mouse models, activation-induced cytidine deaminase (AID/AICDA) was suggested to contribute to BCP-ALL pathogenesis by off-target mutagenic activity. The role of AID in patients, however, remains unclear. Moreover, AID is usually not expressed in precursor B-cells but in germinal center B-cells, where it is induced upon T-helper (Th) cell stimulation. We have previously demonstrated that autologous Th-cells supportively interacted with BCP-ALL-cells. Here, we hypothesize that this interaction additionally induces AID expression in BCP-ALL-cells, leading to off-target mutagenic activity. We show that co-culture with autologous bone marrow Th-cells induced high AICDA expression in primary BCP-ALL-cells. This induction was mediated by a mechanism similar to the induction in mature B-cells involving IL-13/Stat6, CD40L/NF-κB and TGFβ/Smad2/3 signaling. Even though Th-cell-induced AID seemed to be active in vitro in a BCP-ALL reporter cell line, extensive mutational signature analysis revealed no major contribution of AID activity to the mutational landscape in BCP-ALL patients. AID activity was neither detected in mutation clusters nor in known AID targets. Moreover, no recurrently mutated gene showed a relevant enrichment of mutations in the AID motif. Together, the lack of AID-induced mutational consequences argues towards a Th-cell-promoted yet AID-independent BCP-ALL pathogenesis and favors therapeutic research focusing on Th-cell-derived support of BCP-ALL-cells rather than AID-induced effects.
Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden
Authors: Salehi-Rad Ramin , Li Rui , Tran Linh M. , Lim Raymond J. , Abascal Jensen , Momcilovic Milica , Park Stacy J. , Ong Stephanie L. , Shabihkhani Maryam , Huang Zi Ling , Paul Manash , Shackelford David B. , Krysan Kostyantyn , Liu Bin , Dubinett Steven M. 
Published: January 2021

AbstractConditional genetically engineered mouse models (GEMMs) of non-small cell lung cancer (NSCLC) harbor common oncogenic driver mutations of the disease, but in contrast to human NSCLC these models possess low tumor mutational burden (TMB). As a result, these models often lack tumor antigens that can elicit host adaptive immune responses, which limits their utility in immunotherapy studies. Here, we establish Kras-mutant murine models of NSCLC bearing the common driver mutations associated with the disease and increased TMB, by in vitro exposure of cell lines derived from GEMMs of NSCLC [KrasG12D (K), KrasG12DTp53−/−(KP), KrasG12DTp53+/−Lkb1−/− (KPL)] to the alkylating agent N-methyl-N-nitrosourea (MNU). Increasing the TMB enhanced host anti-tumor T cell responses and improved anti-PD-1 efficacy in syngeneic models across all genetic backgrounds. However, limited anti-PD-1 efficacy was observed in the KPL cell lines with increased TMB, which possessed a distinct immunosuppressed tumor microenvironment (TME) primarily composed of granulocytic myeloid-derived suppressor cells (G-MDSCs). This KPL phenotype is consistent with findings in human KRAS-mutant NSCLC where LKB1 loss is a driver of primary resistance to PD-1 blockade. In summary, these novel Kras-mutant NSCLC murine models with known driver mutations and increased TMB have distinct TMEs and recapitulate the therapeutic vulnerabilities of human NSCLC. We anticipate that these immunogenic models will facilitate the development of innovative immunotherapies in NSCLC.
Automatic opportunistic osteoporosis screening in routine CT: improved prediction of patients with prevalent vertebral fractures compared to DXA
Authors: Löffler Maximilian T. , Jacob Alina , Scharr Andreas , Sollmann Nico , Burian Egon , El Husseini Malek , Sekuboyina Anjany , Tetteh Giles , Zimmer Claus , Gempt Jens , Baum Thomas , Kirschke Jan S. 
Published: January 2021

Abstract
Objectives
To compare spinal bone measures derived from automatic and manual assessment in routine CT with dual energy X-ray absorptiometry (DXA) in their association with prevalent osteoporotic vertebral fractures using our fully automated framework (https://anduin.bonescreen.de) to assess various bone measures in clinical CT.

Methods
We included 192 patients (141 women, 51 men; age 70.2 ± 9.7 years) who had lumbar DXA and CT available (within 1 year). Automatic assessment of spinal bone measures in CT included segmentation of vertebrae using a convolutional neural network (CNN), reduction to the vertebral body, and extraction of bone mineral content (BMC), trabecular and integral volumetric bone mineral density (vBMD), and CT-based areal BMD (aBMD) using asynchronous calibration. Moreover, trabecular bone was manually sampled (manual vBMD).

Results
A total of 148 patients (77%) had vertebral fractures and significantly lower values in all bone measures compared to patients without fractures (p ≤ 0.001). Except for BMC, all CT-based measures performed significantly better as predictors for vertebral fractures compared to DXA (e.g., AUC = 0.885 for trabecular vBMD and AUC = 0.86 for integral vBMD vs. AUC = 0.668 for DXA aBMD, respectively; both p < 0.001). Age- and sex-adjusted associations with fracture status were strongest for manual vBMD (OR = 7.3, [95%] CI 3.8–14.3) followed by automatically assessed trabecular vBMD (OR = 6.9, CI 3.5–13.4) and integral vBMD (OR = 4.3, CI 2.5–7.6). Diagnostic cutoffs of integral vBMD for osteoporosis (< 160 mg/cm3) or low bone mass (160 ≤ BMD < 190 mg/cm3) had sensitivity (84%/41%) and specificity (78%/95%) similar to trabecular vBMD.

Conclusions
Fully automatic osteoporosis screening in routine CT of the spine is feasible. CT-based measures can better identify individuals with reduced bone mass who suffered from vertebral fractures than DXA.

Key Points
• Opportunistic osteoporosis screening of spinal bone measures derived from clinical routine CT is feasible in a fully automatic fashion using a deep learning-driven framework (https://anduin.bonescreen.de).
• Manually sampled volumetric BMD (vBMD) and automatically assessed trabecular and integral vBMD were the best predictors for prevalent vertebral fractures.
• Except for bone mineral content, all CT-based bone measures performed significantly better than DXA-based measures.
• We introduce diagnostic thresholds of integral vBMD for osteoporosis (< 160 mg/cm3) and low bone mass (160 ≤ BMD < 190 mg/cm3) with almost equal sensitivity and specificity compared to conventional thresholds of quantitative CT as proposed by the American College of Radiology (osteoporosis < 80 mg/cm3).
Lumbar hemivertebra resection in congenital scoliosis utilizing cone-beam navigation: less radiation, more accuracy—proof of concept
Authors: Fisahn Christian , Lindemann Chris , Burgess Brittni , Strube Patrick , Zippelius Timo 
Published: January 2021

Abstract
Purpose
To present the first known pediatric utilization of cone-beam navigation system (CBNS) for hemivertebra resection and spondylodesis

Case presentation
A 14-year-old female with congenital scoliosis, diagnosed at 8 years of age, presenting with progressive symptoms, a Cobb angle (L3-5) of 38° at time of surgery, treated historically with conservative measures. Presence of spinal intramedullary disease was excluded prior to operation via whole spine MRI.

Results
Patient successfully underwent surgical correction utilizing the CBNS (O-arm™, Medtronic®). Post-operative Cobb angle (L3-5) was restored to 8°. Following four different pediatric patient’s radiation exposures (two receiving correction via the O-arm platform and two via the traditional method employing fluoroscopy), we show a reduction in radiation exposure using the CBNS system.

Conclusion
We present the first known pediatric case of the utilization of the CBNS system for hemivertebra correction. We demonstrate that utilizing the CBNS platform can not only increase surgical accuracy but also decrease pediatric patient’s radiation exposure as a preoperative CT scan is not needed. Future studies should continue to explore additional benefits of implementing the system into surgical practice.
The impact of snow loss and soil moisture on convective precipitation over the Rocky Mountains under climate warming
Authors: Wallace Brendan , Minder Justin R. 
Published: January 2021

AbstractWarm season moist diurnal convection can be particularly sensitive to changes in land surface characteristics such as snow cover and soil moisture. Over regions of mountainous terrain, climate change is expected to reduce snow cover along the low-elevation seasonal snowpack margin. These snow reductions alter surface albedo and soil moisture content, leading to changes in surface fluxes and alterations in mesoscale orographic circulations that act to transport moisture and provide ascent. A set of convection-permitting regional climate simulations centered on the Rocky Mountains of Colorado are conducted from April through July across a period of 12 years (2002–2013). These include a reanalysis forced control run (CTR), a pseudo global warming run (PGW), and an additional altered land surface run (DSURF) used to isolate the effects of the snow albedo and soil moisture changes on orographic convection. Over the mountains, daytime hourly precipitation accumulation (0900–1800 MST) decreased in PGW by an average of 4.2% while precipitation in DSURF increased by 12.5%. On days with weak synoptic forcing, the PGW response more closely follow the DSURF response with daytime hourly increases averaging 29.7% for PGW and 28.7% for DSURF. For PGW, hourly daytime precipitation intensity increases of up to 82% overcome reductions in precipitation frequency to produce higher accumulations. DSURF shows smaller increases in intensity of up to 23% and broad increases in daytime frequency indicating that surface changes act to moderate reductions in the frequency of convective precipitation. Reduced snow cover contributes to this convective response by increasing convective instability and boundary layer moisture and decreasing lifting condensation level over the high terrain. Alterations in orographic thermal circulations contribute to this response by converging moisture over the high terrain and enhancing mesoscale ascent.
The challenging diagnosis and follow-up of skull base osteomyelitis in clinical practice
Authors: Auinger Alice B. , Dahm Valerie , Stanisz Isabella , Schwarz-Nemec Ursula , Arnoldner Christoph 
Published: January 2021

Abstract
Purpose
The disease activity of skull base osteomyelitis can be challenging to assess by means of conventional imaging methods and renders monitoring of the disease difficult, especially in areas with restricted access to nuclear medicine imaging. Here, we provide clinically relevant data on the management of skull base osteomyelitis including assessment, treatment, and follow-up strategies with regards to the role of imaging.

Method
A chart review was performed including 30 patients treated for SBO from 1993 to 2015. Clinical findings, treatment procedures, and complication rates were assessed. Special attention was paid to imaging procedures.

Results
The overall mortality rate was 36.7% and increased to 45% when cranial nerve palsies were present. An initial computed tomography (CT) scan was performed in all patients, MRI in 60% and nuclear imaging in 33%. CT scans failed to detect progression or regression in up to 80% after four to nine months. MRI examinations could reveal changes at a higher rate compared to CT. Nuclear medicine functional imaging was most likely to assess disease activity.

Conclusion
A combination of different imaging modalities is recommended for diagnosing SBO. For the follow-up, MRI is preferable to CT as changes can be detected more readily with MRI. If available, nuclear medicine imaging should guide the decision of treatment discontinuation.
FOXO1 gene involvement in a non-rhabdomyosarcomatous neoplasm
Authors: Haefliger Simon , Genevay Muriel , Bihl Michel , Marone Romina , Baumhoer Daniel , Papaloizos Michael , Matter Matthias S. , Bode-Lesniewska Beata 
Published: January 2021

AbstractMyoepithelial neoplasms of soft tissue are rare tumors with clinical, morphological, immunohistochemical, and genetic heterogeneity. The morphological spectrum of these tumors is broad, and the diagnosis often requires immunostaining to confirm myoepithelial differentiation. Rarely, tumors show a morphology that is typical for myoepithelial neoplasms, while the immunophenotype fails to confirm myoepithelial differentiation. For such lesions, the term “myoepithelioma-like” tumor was introduced. Recently, two cases of myoepithelioma-like tumors of the hands and one case of the foot were described with previously never reportedOGT-FOXOgene fusions. Here, we report a 50-year-old woman, with a myoepithelial-like tumor localized in the soft tissue of the forearm and carrying aOGT-FOXO1fusion gene. Our findings extend the spectrum of mesenchymal tumors involving members of the FOXO family of transcription factors and point to the existence of a family of soft tissue tumors that carry the gene fusion of the OGT-FOXO family.
Ethnic disparities in postpartum hemorrhage after cesarean delivery: a retrospective case–control study
Authors: Wang Yu , Gao Hexin , Bao Tuvshin , Yang Lijuan , Ding Guifeng , Ba Demu , Sun Shujun , Lin Yun , Yao Shanglong 
Published: January 2021

Abstract
Purpose
To explore the relationship of ethnicity and postpartum hemorrhage (PPH) for women who underwent cesarean delivery (CD) and examine the risk factors for PPH in distinct ethnic groups in China.

Methods
We conducted case–control studies with the maternity data from the 11,778 CD cases, in Xinjiang Uygur Autonomous Region. Initially, multivariable logistic regression was used to estimate the disparity of race-ethnicity on the risk of PPH in ethnic Han, Uygur, Hui and Kazakh. Then, we performed case–control studies within two major ethnic groups, identifying the specific risk factors for PPH.

Results
Ethnic Uygur were associated with a statistically significant increased odds [adjusted odds ratios (aOR) 2.05; 95% confidence interval (CI) 1.26–3.33] of PPH compared with ethnic Han. For subgroup analyses, in Uygur subgroup, general anesthesia (aOR 7.78; 95% CI 2.31–26.20); placenta previa (aOR 11.18; 95% CI 3.09–40.45); prenatal anemia (aOR 4.84; 95% CI 2.44–9.60); emergency surgery (aOR 4.22; 95% CI 1.95–9.13) were independently associated with PPH. In Han subgroup, general anesthesia (aOR 5.70; 95% CI 1.89–17.26); placenta previa (aOR 20.08; 95% CI 6.35–63.46); multiple pregnancy (aOR 7.21; 95% CI 1.61–32.37); body mass index (aOR 1.19; 95% CI 1.07–1.31) were the risk factors to PPH.

Conclusion
Uygur have more tendency to PPH compared to Han, and risk factors for PPH in Uygur and Han groups may differ. Knowing these differences may be meaningful when planning interventions and resources for high-risk patients undergoing cesarean delivery, and we need more research aimed at risk factors for PPH.