bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follicular Fluid Perfluoroalkyl and Polyfluoroalkyl Substances Are Associated With Adverse ART Outcomes in Women With Poor Ovarian Reserve
Authors: Cai Yunying , Zhong LanPing , Wu Ze , Wang Min , Su Heng 
Published: August 2021

Abstract
BackgroundPrevious evidence suggests that perfluoroalkyl and polyfluoroalkyl substances (PFASs) adversely affect ovarian function and female fecundity. However, the evidence remains insufficient to infer a direct relationship between PFAS exposure and adverse assisted reproductive technology (ART) outcomes. To fill this gap, we examined follicular fluid PFAS exposure and ART outcomes in patients with poor ovarian reserve (POR) in a prospective study.MethodsIn total, 147 women with POR were included. Eight PFASs were measured in follicular fluid (n=104) samples using simultaneous analysis by ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. The PFAS contamination status of the patients’ follicular fluid and the association between characteristics and ART outcomes were investigated by logistic regression.ResultsAfter adjustment for age and BMI, PFOA, PFNA, PFHxS and ∑PFAS were strongly associated with a decreased probability of pregnancy (PFOA highest vs. lowest tertile: OR=1.95, 95% CI: 1.61, 2.38; PFNA highest vs. lowest tertile: OR= 3.0, 95% CI: 2.46, 3.68; PFHxS highest vs. lowest tertile: OR= 1.95, 95% CI: 1.61, 2.35; ∑PFAS second vs. lowest tertile: OR=3.31, 95% CI: 2.74, 3.89). PFOS and PFUnDA were inversely associated with failed implantation. No relationships were noted between failed implantation and other PFAS analytes. The same result was obtained when using live birth as an outcome measure.ConclusionsIn women with POR, follicular fluid PFAS exposure may decrease the probability of clinical pregnancy and live birth.
Functionalized lignin-based-adsorbent derived from black liquor in the paper industry for superior adsorption characteristics.
Authors: Hamad Hesham , Elhafez Sara Abd , Sorour Mariam , Amin Nevin , Abdelwahab Ola , El-Ashtoukhy Elsayed 
Published: August 2021

Abstract
Lignin's availability in large amounts from industrial black liquor as waste from the paper industry is still a problem. On the other hand, its utilization potentials as a green low-cost adsorbent for the effective removal of toxic organic dye from industrial wastewater has become a topic of great interest but remains quite challenging. In this sense, this work aimed to evaluate the feasibility of removing the reactive green dye (RGD) onto the functionalized lignin-based adsorbent (FLA) by the acidic method. The kinetic study suggested the adsorption process confirmed to a pseudo-second-order-kinetic and intra-particle diffusion models. Also, the isotherm results showed that the FLA exhibited multi-layer adsorption. Meanwhile, the results of FTIR and SEM showed that the RG-19 adsorption mechanisms were electrostatic interaction, hydrogen bonding, π-π stacking, and physical adsorption. Thermodynamic parameters were also evaluated and their values indicated that adsorption of RG-19 onto FLA is an exothermic process and spontaneous in nature. As a renewable, low-cost, and natural biomass material, FLA has the potential to be used as a promising sustainable and economic application of biomass and will inspire more scholars to investigate solutions to the problem of contaminated water resources.
A Phenomenological Experience of Trainer with COVID-19 Training: A Tertiary Level Institution Experience with Simulation
Authors: Rohilla Kusum K , Varghese Arun , Kalyani C Vasantha , Singh Neha , Rao Shalinee 
Published: August 2021

Abstract
Background: Highly infectious diseases like COVID-19, which are rapidly disseminating and exceedingly contagious, require vital safety skills to be followed by all health professionals. These safety skills need to be taught to all individuals working in the health care sector, by qualified trainers. The present study describes the experiences of COVID-19 trainers who were involved in providing this intensive training to health workers, in a tertiary level institution. The hospital was providing services to COVID positive patients, as well as emergency and tertiary care services during the COVID-19 pandemic. Most of the participants in the study were high risk groups who were in direct interaction with COVID positive patients.Methods: The COVID-19 training program was conducted for more than three months, with the aim of training all the health care workers at a tertiary care institute, during the Corona virus pandemic. Twenty trainers, who had completed at least 30 or more sessions of training more than 2700 health workers, were included in this study. These trainers were interviewed for an average of thirty minutes per participant and were asked 30 open ended questions each. Results: The mean age of the trainers was 28.9 years, and 75% of them were females. The interview of the COVID-19 trainers highlighted four important factors, which according to them were the pillars of this successful and effective training program. These factors included: The use of video demonstration and simulation for the training; Regular updating of the skill of the trainers in this program; Ease of communication to address the challenges faced by the trainers; and strong administrative support for the training. Conclusion: The results of this study reveal that if health workers are provided a conducive environment for training, as well as full support for updating their knowledge and skills, they can provide optimal health care services to their patients and fellow healthcare workers, even during a challenging time like the COVID-19 pandemic. The trainers in this study provided training to all the health care workers of the hospital, who were posted in COVID wards, even at a time when everyone had the fear of contracting the infection.
The objective need for legal regulation of territorial planning  and its implementation in the Republic of Lithuania
Authors: Mikalauskaitė-Šostakienė Kristina 
Published: August 2021

The article analyzes the social and legal assumptions that determine the need for the legal regulation of territorial planning. The extent to which the appropriate legal regulation of territorial planning is related to the protection of the environment, ensuring sustainable development and the protection of human rights is assessed. It is concluded that the process of territorial planning is complex and complicated, has different needs and interests of natural and legal persons regarding the use of the respective territories are constantly encountered. Although the reform of the legal regulation of territorial planning has been carried out three times in Lithuania, gaps in the legal regulation of territorial planning have been identified so far.
Peles Pretas Importam
Authors: Dantas Mariana , Laís dos Santos Júlia , Aires Araújo Paloma , Regina Vieira Beatriz , Teixeira de Oliveira Addonai 
Published: August 2021

O presente trabalho corresponde a um relato de experiência da atividade “Peles Pretas Importam”, desenvolvida por estudantes de medicina filiados à International Federation of Medical Students’ Associations of Brazil (IFMSA Brazil) – uma organização estudantil cuja missão consiste em contribuir para a formação de profissionais de saúde mais humanizados, empáticos e socialmente responsáveis através da extensão universitária. A intervenção, ambientada em moldes remotos devido à pandemia de COVID-19, objetivou abordar com maior profundidade as particularidades dermatológicas referentes à pele negra, uma vez que praticamente todas as referências da literatura dão enfoque apenas a peles mais claras.
Palavras-chave: extensão; dermatologia; saúde da população negra.
Scutellaria baicalensis Extract-phospholipid Complex: Preparation and Initial
Pharmacodynamics Research in Rats
Authors: Chen Shibin , Xie Qiujie , Yang Ming , Shi Yajun , Shi Junhui , Zeng Xiaobin 
Published: August 2021

Background:
Baicalin, a flavonoid glycoside compound present in Scutellaria baicalensis,
has shown a wide spectrum of biological activities, but its liposolubility, water-solubility and
mucosal permeability are all very poor, which leads to the low concentration in brain and poor
bioavailability by oral or intravenous injective administration.

Objective:
The primary objective of this study was to formulate the Scutellaria baicalensis extract
(SBE) with phospholipid to yield Scutellaria baicalensis extract-phospholipid complex (SBEPC) ,
and to evaluate its pharmacodynamics in the middle cerebral artery occlusion (MCAO).

Methods:
The optimal preparation technology of SBEPC was obtained through single-factor test
and central composite design-response surface methodology (CCD-RSM), and was characterized
with various analytical techniques including SEM, FT-IR and NMR. The storage conditions of
SBEPC were established through stability study and the MCAO rat model was investigated
through conducting pharmacodynamic studies to screen the appropriate administration and dose of
SBEPC as well as to verify the neuroprotective effect of SBEPC on cerebral ischemia-reperfusion
injury.

Results:
The optimized preparation conditions of SBEPC were summarized as follows: the ratio of
phospholipids to drug was 2:1, the drug concentration was 3.5 mg/ml, the reaction temperature was
50 °C, and the entrapment efficiency was over 93.00%. Stability studies have demonstrated that
SBEPC should be stored under 40 °C in a dry and ventilated place away from light and below 37%
humidity. Furthermore, pharmacodynamic studies have found that, compared with SBE, SBEPC
could introduce drugs into the brain and better exert the neuroprotective effect on MCAO rats, and
the optimal administration and dose concentration of SBEPC were nasal administration and 40
mg/ml, respectively.

Conclusion:
These findings demonstrate that SBEPC is successfully prepared by CCD-RSM.
SBEPC can enhance drugs' ability to enter the brain and improve the bioavailability of drugs in
brain, and can effectively exert the neuroprotective effect on cerebral ischemia-reperfusion injury
as compared with SBE.
Ubiquitin Mediated Degradation of EGFR by 17 β-estradiol in Triple
Negative MDA-MB-231 (TNBC) Breast Cancer Cells Line
Authors: Khode Vitthal , Patil Sumangala , Kaveeshwar Vishwas , Ruikar Komal , Bargale Anil , E. Sarathkumar , Patil Satish 
Published: August 2021

Background:
Triple Negative Breast Cancer (TNBC) commonly displays
Epidermal growth factor receptor (EGFR). Effective EGFR degradation results in the
suppression of tumor in various models. Studies have addressed the relevance of this
strategy in the treatment of TNBC. In the present study, we examined the effect of 17 β-
estradiol on EGFR expression in MDA-MB-231 (TNBC) cell line and assessed whether
17 β-estradiol degrades EGFR by ubiquitination pathway.

Objectives:
The objectives of this study are to treat MDA-MB-231 cell lines with
Cycloheximide with or without 17β-estrdiol to observe whether 17β-estradiol leads to
EGFR degradation and to treat with MG-132 to assess whether degradation occurs
through ubiquitination pathway.

Methods:
MDA-MB-231 cells were treated with 17β-estradiol (E2) and EGFR
expression was studied by western blotting at different intervals by using Cycloheximide
chase. To assess ubiquitination pathway of degradation of EGFR in MDA-MB-231 cell
line, MG-132 was used.

Results:
EGFR expression was reduced with β-estradiol treatment in MDA-MB-231 cell
line with Cycloheximide chase. Upon Treatment with MG-132 and E2, EGFR expression
did not reduce, suggesting that Estrogen degrades EGFR by ubiquitination pathway.

Conclusion:
Estrogen degrades EGFR in MDA-MB-231 cells and this degradation
occurs by ubiquitination.
Role of Glycogen Synthase Kinase-3 in the Etiology of Type 2 Diabetes Mellitus: A Review
Authors: Bala Asis , Roy Susmita , Das Debanjana , Marturi Venkatesh , Mondal Chaitali , Patra Susmita , Haldar Pallab Kanti , Samajdar Gourav 
Published: August 2021

Abstract:The risk of type 2 diabetes mellitus (T2DM) is increasing abundantly due to lifestyle-related obesity and associated cardiovascular problems. Presently, Glycogen synthase kinase-3 (GSK-3) has gained considerable attention from biomedical scientists to treat diabetes. Phosphorylation of GSK-3 permits a number of cellular activities like regulation of cell signaling, cellular metabolism, cell proliferation and cellular transport. Inhibiting GSK-3 activity by pharmacological intervention has become an important strategy for the management of T2DM. This review focuses on the schematic representation of fundamental GSK-3 enzymology and encompasses the GSK-3 inhibitors as a future therapeutic lead target for the management of T2DM that may significantly regulate insulin sensitivity to insulin receptor, glycogen synthesis and glucose metabolism. The various signaling mechanisms of inhibiting the GSK-3 by describing insulin signaling through Insulin Receptor Substrate (IRS-1), Phosphatidylinositol-3 Kinase (PI3K) and Protein Kinase B (PKB/ AKT) pathways that may hopefully facilitate the pharmacologist to design for antidiabetic drug evaluation model in near future have also been highlighted.
Current Strategies to Minimize Ischemia-Reperfusion Injury in Liver
Transplantation: A Systematic Review
Authors: Gazia Carlo , Lenci Ilaria , Manzia Tommaso M , Martina Milana , Tisone Giuseppe , Angelico Roberta , Abenavoli Ludovico , Grassi Giuseppe , Signorello Alessandro , Baiocchi Leonardo 
Published: August 2021

Background:
Hepatic Ischemia Reperfusion Injury (IRI) is a serious threat that characterizes
the liver but also other transplantable organs. The worst effect of long-term IRI on an impaired
graft could lead to irreversible damage and organ failure. Several events characterize the cascade
that ultimately leads to organ failure. Among all, multiple strategies have been attempted to
identify early phenomena of IRI with divergent results, and biomarkers might represent a novel approach
to early detect ischemic damage.

Methods:
A literature review of the current state-of-the-art on IRI was conducted in the present
manuscript. Information was collected from worldwide clinical trials conducted in highly specialized
institutions. Experiments conducted on IRI animal models and clinical studies were screened.
The final outcomes were analyzed and reported in the present review.

Results:
Matrix Metalloproteinases (MMPs) represent an interesting example of the early detector
of neutrophil invasion after acute and chronic hepatic IRI. Neutrophil Gelatinase-associated Lipocalin
(NGAL) is another biomarker which seems more predictable of the IRI gravity phase. Mitochondrial
flavin mononucleotide (FMN) was recently discovered and might become a reliable biomarker
of hepatic IRI during Hypothermic Oxygenation Machine Perfusion (HOPE).

Conclusion:
The available strategies to avoid IRI, despite constantly improving, are still lacking a
gold standard method. Further studies are still needed to explore new options in the IRI diagnosis
and treatment, and to this purpose, regenerative medicine and tissue engineering surely can play a
pivotal role in the transplantation field.
View and Experiences of Unwanted Pregnancy Among Malays Teenage Mother
Authors: Sham Fatimah , Ismail Afiqah , Tuan Him Tuan Nor Ashikin , Razali Salmi 
Published: August 2021

Ex-nuptial pregnancy among teenagers in Malaysia associates with negative consequences. However, perspective from them is lacking. To explore their experiences and perspective in addressing this phenomenon. In-depth face-to-face interviews were conducted with informed consent among 10 young women who experienced becoming unwed mothers during adolescents. Data were encoded and analyse using Qualitative Data Analysis Miner Program and interpretative phenomenological analysis. Four themes emerged; sexual activity trajectory, motherhood struggles to them, formula of resilience teenage mothers and life after misery. Perspectives from them are vital. Great support strategies could assist them for a better life.
Keywords: teenage, motherhood, pregnant, sexuality, Malaysia
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6iSI4.2896
The Malaysian Garden Concept Design Branding: Whose Role is it Anyway?
Authors: Zakaria Ahmad Zamil , Md Dali Melasutra , Hussein Hazreena 
Published: August 2021

Two decades ago, Malaysian leaders had expressed their desire to have a garden design concept that can represent Malaysia. This study explores the Malaysian Garden Concept (MGC) branding from the perspectives of experts recognized by the National Landscape Department (NLD). This study applies a qualitative research method, in which researchers have interviewed respondents using specific effective techniques. The MGC is meant for public parks and designed for all uses but has some significant issues. The finding found that intensive promotion, marketing, and advertising can help implement the concept of Malaysian Garden in the future.
Keywords: Malaysian Garden; National Identity; Landscape Architecture; Concept Branding
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6iSI4.2914
Effect of a Brief Web-Based Educational Intervention on Willingness to Consider Human Papillomavirus Vaccination for Children in Japan: Randomized Controlled Trial
Authors: Suzuki Yukio , Sukegawa Akiko , Ueda Yutaka , Sekine Masayuki , Enomoto Takayuki , Miyagi Etsuko 
Published: August 2021

Background
The human papillomavirus (HPV) vaccination rate in Japan has fallen to nearly zero since the suspension of governmental proactive recommendations in 2013, owing to the development of purported adverse events.

Objective
This study aimed to evaluate the effects of a brief web-based educational intervention using the theory of behavioral insights on the willingness of adults to consider the HPV vaccine for their daughters and sons.

Methods
We recruited 1660 participants aged 20 years or older in March 2018 via a webpage and provided them with a 10-item questionnaire related to the following aspects: awareness regarding HPV infection and vaccination, willingness for immunization, and actions for prevention. We randomly stratified participants based on sex and age with or without a brief educational intervention involving scientific information presented in an easy-to-read format.

Results
Only 484 (29.2%) of the respondents were aware of the benefits of HPV vaccination. Although only 352 (21.2%) of the respondents displayed a willingness for immunization of their daughters, there were 40 (4.8%) more respondents in the intervention group with this willingness (adjusted odds ratio [aOR] 1.32, 95% CI 1.04-1.69). In a subanalysis, the willingness toward vaccination for daughters in men was significantly higher in the intervention group (aOR 1.46, 95% CI 1.05-2.02). However, such a difference was not observed among women (aOR 1.20, 95% CI 0.83-1.73).

Conclusions
This study suggests that a brief web-based educational intervention increases the willingness of adults to consider the HPV vaccine for their children, especially among men. Thus, providing adequate information to men may be a useful strategy to improve the currently low rates of HPV vaccination.

Trial Registration
UMIN Clinical Trials Registry UMIN000049745 (UMIN-CTR); https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049745
Política fiscal y financiera y grupos empresariales en México
Authors: Bernal Soriano Irma I. 
Published: August 2021

<p>El artículo revisa la historia del capital financiero en nuestro país por medio de la historia de los grupos financieros. Dicho fenómeno económico tuvo lugar durante el modelo de la industrialización por sustitución de importaciones, siendo éste el contexto económico. El hilo conductor del análisis versa sobre el cuestionamiento siguiente: ¿Cómo se alcanzaron las estrechas<strong> </strong>vinculaciones financieras de los grupos empresariales con el capital financiero, para integrar a los bancos y/o casas de bolsa en el grupo empresarial, de tal manera que se diera lugar a los grupos financieros? Para tal propósito se analiza el proceso histórico en la formación de los grupos empresariales, y financieros mexicanos; así como la incidencia de la política fiscal y financiera a su favor. La parte final está dedicada a las conclusiones.</p><div><div><p> </p></div><div> </div></div>
Brasil: consecuencias del Covid-19. Crisis multidimensional en tres actos
Authors: Costa Lima Marcos , Fonseca Pedro 
Published: August 2021

<p>Este artículo tiene como objetivo analizar las acciones de gobierno de Bolsonaro en la lucha contra el Covid-19 y debatir cuáles son las consecuencias pospandémicas para Brasil. Nuestro principal argumento es que las acciones del gobierno de Bolsonaro han contribuido a agravar la crisis multidimensional que sufre Brasil desde 2016, cuando se produjo el juicio político (<em>impeachment</em>) a la presidenta Dilma Roussef. Las acciones del gobierno de Bolsonaro están guiadas por un populismo que tiene como principal característica lo anticientífico y que tiene como resultado un promedio de más de 2000 muertes por día con proyecciones de llegar a 3000 muertes.</p><div><div><p> </p></div></div>