bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
Authors: Kim Joonghee , Park Sang Jun , Choi Sangbum , Seo Won-woo , Lee Yeon Joo 
Published: May 2021

AbstractIt is well established that the risk of acute coronary syndrome (ACS) increases after respiratory infection. However, the reverse association has not been evaluated. We tested the hypothesis that the long-term risk of pneumonia is increased after a new ACS event. A matched-cohort study was conducted using a nationally representative dataset. We identified patients with admission for ACS between 2004 and 2014, without a previous history of ACS or pneumonia. Incidence density sampling was used to match patients, on the basis of age and sex, to 3 controls who were also free from both ACS and pneumonia. We examined the incidence of pneumonia after ACS until the end of the cohort observation (Dec 31, 2014). The analysis cohort consisted of 5469 ACS cases and 16,392 controls (median age, 64 years; 68.3% men). The incidence rate ratios of the first and the total pneumonia episodes in the ACS group relative to the control group was 1.25 (95% confidence interval [CI], 1.11–1.41) and 1.23(95% CI 1.11–1.36), respectively. A significant ACS-related increase in the incidence of pneumonia was observed in the Cox-regression, shared frailty, and joint frailty model analyses, with hazard ratios of 1.25 (95% CI 1.09–1.42), 1.35 (95% CI 1.15–1.58), and 1.24 (95% CI 1.10–1.39), respectively. In this population-based cohort of patients who were initially free from both ACS and pneumonia, we found that hospitalization for ACS substantially increased the long term risk of pneumonia. This should be considered when formulating post-discharge care plans and preventive vaccination strategies in patients with ACS.
An integrative network analysis framework for identifying molecular functions in complex disorders examining major depressive disorder as a test case
Authors: Oommen Anup Mammen , Cunningham Stephen , O’Súilleabháin Páraic S. , Hughes Brian M. , Joshi Lokesh 
Published: May 2021

AbstractIn addition to the psychological depressive phenotype, major depressive disorder (MDD) patients are also associated with underlying immune dysregulation that correlates with metabolic syndrome prevalent in depressive patients. A robust integrative analysis of biological pathways underlying the dysregulated neural connectivity and systemic inflammatory response will provide implications in the development of effective strategies for the diagnosis, management and the alleviation of associated comorbidities. In the current study, focusing on MDD, we explored an integrative network analysis methodology to analyze transcriptomic data combined with the meta-analysis of biomarker data available throughout public databases and published scientific peer-reviewed articles. Detailed gene set enrichment analysis and complex protein–protein, gene regulatory and biochemical pathway analysis has been undertaken to identify the functional significance and potential biomarker utility of differentially regulated genes, proteins and metabolite markers. This integrative analysis method provides insights into the molecular mechanisms along with key glycosylation dysregulation underlying altered neutrophil-platelet activation and dysregulated neuronal survival maintenance and synaptic functioning. Highlighting the significant gap that exists in the current literature, the network analysis framework proposed reduces the impact of data gaps and permits the identification of key molecular signatures underlying complex disorders with multiple etiologies such as within MDD and presents multiple treatment options to address their molecular dysfunction.
The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats
Authors: Rahmati Masoud , Taherabadi Seyed Jalal 
Published: May 2021

AbstractKinesin-1 and Growth Associated Protein 43 (GAP-43) localization in muscle fiber are crucial for proper skeletal muscle hypertrophy. To evaluate this assumption, we investigated the beneficial effects of endurance training on GAP-43 and Kinesin Family Member 5B (KIF5B) expression in gastrocnemius muscle of streptozotocin (STZ)-induced diabetic rats. Fifty-two male rats were randomly divided into four groups: healthy control (C), healthy trained (T), diabetic control (DC) and diabetic trained (DT). Diabetes was induced by a single intraperitoneal injection of STZ (45 mg/kg). The rats in DT and T groups were subjected to treadmill running for 5 days a week over 6 weeks. The results indicated that the GAP-43 and KIF5B protein levels in the DC group were significantly lower than those in the C group. Additionally, chronic treadmill running in diabetic rats was accompanied by significant increase of GAP-43 and KIF5B protein expression, compared to DC group. Furthermore, the endurance training in healthy rats was associated with a significant increase of GAP-43 and KIF5B protein levels. In addition, we found positive correlation between GAP-43 and KIF5B protein levels and myonuclear number per fiber and average gastrocnemius cross-sectional area (CSA). GAP43 and KIF5B protein levels were decreased in skeletal muscles of diabetic rats, and exercise training had beneficial effects and could restore their abnormal expression. Moreover, there is a strong relationship between muscle hypertrophy and GAP-43 and KIF5B protein levels.
Effect of transcranial direct current stimulation on the psychomotor, cognitive, and motor performances of power athletes
Authors: Grosprêtre Sidney , Grandperrin Yohan , Nicolier Magali , Gimenez Philippe , Vidal Chrystelle , Tio Gregory , Haffen Emmanuel , Bennabi Djamila 
Published: May 2021

AbstractIn sports science, transcranial direct current stimulation (tDCS) has many unknown effects on neuromuscular, psychomotor and cognitive aspects. Particularly, its impact on power performances remains poorly investigated. Eighteen healthy young males, all trained in a jumping sport (parkour) performed three experimental sessions: anodal tDCS applied either on the left dorsolateral prefrontal cortex (dlPFC, cathode in supraorbital area) or on the primary motor cortex (M1, cathode on contralateral shoulder), and a placebo condition (SHAM), each applied for 20 min at 2 mA. Pre and post, maximal vertical and horizontal jumps were performed, associated to leg neuromuscular assessment through electromyography and peripheral nerve stimulations. Actual and imagined pointing tasks were also performed to evaluate fine motor skills, and a full battery of cognitive and psychomotor tests was administered. M1 tDCS improved jump performance accompanied by an increase in supraspinal and spinal excitabilities. dlPFC stimulation only impacted the pointing tasks. No effect on cognitive tests was found for any of the tDCS conditions. To conclude, the type of performance (maximal versus accurate) affected depended upon the tDCS montage. Finally, athletes responded well to tDCS for motor performance while results to cognitive tests seemed unaffected, at least when implemented with the present rationale.
Sensory gene identification in the transcriptome of the ectoparasitoid Quadrastichus mendeli
Authors: Huang Zong-You , Wang Xiao-Yun , Lu Wen , Zheng Xia-Lin 
Published: May 2021

AbstractSensory genes play a key role in the host location of parasitoids. To date, the sensory genes that regulate parasitoids to locate gall-inducing insects have not been uncovered. An obligate ectoparasitoid, Quadrastichus mendeli Kim & La Salle (Hymenoptera: Eulophidae: Tetrastichinae), is one of the most important parasitoids of Leptocybe invasa, which is a global gall-making pest in eucalyptus plantations. Interestingly, Q. mendeli can precisely locate the larva of L. invasa, which induces tumor-like growth on the eucalyptus leaves and stems. Therefore, Q. mendeli–L. invasa provides an ideal system to study the way that parasitoids use sensory genes in gall-making pests. In this study, we present the transcriptome of Q. mendeli using high-throughput sequencing. In total, 31,820 transcripts were obtained and assembled into 26,925 unigenes in Q. mendeli. Then, the major sensory genes were identified, and phylogenetic analyses were performed with these genes from Q. mendeli and other model insect species. Three chemosensory proteins (CSPs), 10 gustatory receptors (GRs), 21 ionotropic receptors (IRs), 58 odorant binding proteins (OBPs), 30 odorant receptors (ORs) and 2 sensory neuron membrane proteins (SNMPs) were identified in Q. mendeli by bioinformatics analysis. Our report is the first to obtain abundant biological information on the transcriptome of Q. mendeli that provided valuable information regarding the molecular basis of Q. mendeli perception, and it may help to understand the host location of parasitoids of gall-making pests.
Expression of therapy-induced senescence markers in breast cancer samples upon incomplete response to neoadjuvant chemotherapy
Authors: Saleh Tareq , Alhesa Ahmad , Al-Balas Mahmoud , Abuelaish Omar , Mansour Ahmad , Awad Heyam , El-Sadoni Mohammed , Carpenter Valerie J. , Azab Bilal 
Published: May 2021

Abstract
Senescence is a cell stress response induced by replicative, oxidative, oncogenic, and genotoxic stresses. Tumor cells undergo senescence in response to several cancer therapeutics in vitro (Therapy-Induced Senescence, TIS), including agents utilized as neoadjuvant chemotherapy (NAC) in the treatment of invasive breast cancer. TIS has been proposed to contribute to adverse therapy outcomes including relapse. However, there is limited evidence on the induction of senescence in response to NAC in clinical cancer and its contribution to disease outcomes. In this work, the expression of three senescence-associated markers (p21CIP1, H3K9Me3 (histone H3 lysine 9 trimethylation), and Lamin B1) was investigated in breast cancer samples that developed partial or incomplete pathological response to NAC (n=37). Accordingly, 40.54% of all samples showed marker expression consistent with a senescence-like phenotype, while the remainders were either negative or inconclusive for senescence (2.70 and 56.8%, respectively). Moreover, analysis of core-needle biopsies revealed minimal changes in p21CIP1 and H3K9Me3, but significant changes in Lamin B1 expression levels following NAC, highlighting a more predictive role of Lamin B1 in senescence detection. However, our analysis did not establish an association between TIS and cancer relapse as only three patients (8.1%) with a senescence-like profile developed short-term recurrent disease. Our analysis indicates that identification of TIS in tumor samples requires large-scale transcriptomic and protein marker analyses and extended clinical follow-up. Better understanding of in vivo senescence should elucidate its contribution to therapy outcomes and pave the way for the utilization of senolytic approaches as potential adjuvant cancer therapy.
Survey of Clinician Perspectives and Practices Regarding Swallowing-Related Fatigue
Authors: Brates Danielle , Namasivayam-MacDonald Ashwini , Molfenter Sonja M. 
Published: May 2021

IntroductionFatigue is commonly identified by clinicians who evaluate and treat swallowing impairment despite a lack of research in this area. The purpose of this study was to understand the current role of swallowing-related fatigue in dysphagia evaluation with respect to (a) clinician practices, (b) perspectives, and (c) desire for resources regarding swallowing-related fatigue.MethodA survey was conducted by licensed speech-language pathologists who evaluate and treat adult dysphagia. The survey was distributed via dysphagia-focused groups on Facebook and Special Interest Group 13. Data were analyzed descriptively and by thematic analysis for free-text response questions.ResultsOut of 426 prospective respondents, 311 completed the survey (response rate = 73.0%). While 86% of respondents agreed that fatigue may be a concern for individuals with swallowing impairment, there was wide variability in how clinicians define and evaluate swallowing-related fatigue, and the majority (62%) define fatigue in two or more ways. Explicit evaluation of fatigue was reportedly conducted by 45% of respondents during the Clinical Swallowing Evaluation, by 38% during videofluoroscopic swallowing study, and by 53% during Flexible Endoscopic Evaluation of Swallowing. The most common methods for identifying fatigue were general declines in performance over the course of the assessment. Respondents reported much more reliance on patient report during Clinical Swallowing Evaluation (41%) compared to videofluoroscopic swallowing study (7%) and fiberoptic endoscopic evaluation of swallowing (5%). Only 7% of respondents reported being aware of any standardized methods for assessing fatigue, while 97% of respondents affirmed interest in incorporating standardized methods for assessing swallow-related fatigue.ConclusionsOur results demonstrated wide variability in how currently practicing clinicians define and evaluate swallowing-related fatigue, despite the vast majority considering fatigue to be an important factor in dysphagia evaluation. This study highlights a critical gap in the clinical evaluation of swallowing and requires significant further study to guide clinical practice.
Empirical Study on the relationship between freight volume and economic development of provinces and cities in China
Authors: Shanshan Chu 
Published: May 2021

The transportation industry is the basic and leading industry of the national economy, and it is an important pillar of the national economy. The freight transportation is an important part of the transportation and plays an important role in the economic development. At the same time, the development of freight transport itself is also affected by the economy. Therefore, this paper studies the relationship between cargo transportation and economic growth, and explores the internal relationship and law between them, so as to provide reference for the development of cargo transportation and the growth of national economy.
This paper selects the freight volume and GDP indicators of 31 provinces and cities in China from 1993 to 2018, and discusses the development trend of GDP and freight volume from the perspective of provinces and cities. The results are as follows: 1. Freight volume and GDP showed an upward trend from 1993 to 2018, but the growth of freight volume was slower than that of GDP. 2. There is a co integration relationship between GDP and freight volume, and the national GDP increases by 0.954% for every 1% increase in freight turnover. 3. There are differences in the driving effect of freight volume in typical regions and provinces.
Selbsthilfeverbände: Bundesselbsthilfeverband für Osteoporose e. V.
Authors: Klatt Gisela , Freikamp Thorsten 
Published: May 2021

ZusammenfassungVorstellung des Bundesselbsthilfeverbandes für Osteoporose e. V. (BfO) als größte Patientenorganisation zum Krankheitsbild Osteoporose weltweit mit 15000 Patienten. Der BfO vertritt die Interessen der Betroffenen in der Öffentlichkeit und setzt sich für die Verbesserung der Versorgungssituation der Osteoporose-Patienten ein. Als originäre ehrenamtlich geführte Selbsthilfeorganisation ist der BfO dem Prinzip der gegenseitigen Unterstützung von Personen gleicher Betroffenheit verpflichtet. Neben psychosozialer Unterstützung und praktischer Lebenshilfe bietet der Verband qualitätsgesicherte Osteoporose-Gymnastik (Funktionstraining) an, die von der GKV finanziell gefördert wird. Wissenschaftliche Untersuchungen haben gezeigt, dass die Mitgliedschaft in einer Selbsthilfegruppe und die regelmäßige Teilnahme an den angebotenen Bewegungsprogrammen einen positiven Einfluss auf den Therapieverlauf haben.
Correlation Between Diagnostic Imaging Findings of Sacroiliitis and
Inflammation Parameters
Authors: Şan Hüseyin , Şan Ayça Uran 
Published: May 2021

Abstract
Objectives Sacroiliitis is an inflammation of the sacroiliac joints.
Diagnostic imaging has a very important role in the diagnosis of sacroiliac
involvement in the disease process. In addition, laboratory parameters can also
be useful for the detection of inflammation. This study aims to investigate the
relationship between active sacroiliitis and subclinical inflammation parameters
in patients who underwent MRI and 99mTc-methylene diphosphonate (MDP) bone
scintigraphy.
Material and Methods This study includes 65 patients with suspected
spondyloarthritis (SpA). Patients who had a sacroiliac MRI, a 99mTc-MDP bone
scintigraphy and a complete blood count (CBC) within 3 months were reviewed
retrospectively. Sacroiliac joints were evaluated bilaterally by using bone
scintigraphy and MRI. Blood inflammation parameters were further assessed
regarding evidence of probable sacroiliitis.
Results Significant differences were reported between MRI groups for
sacroiliac indices (SII) (p=0.003), neutrophil-to-lymphocyte ratio (NLR)
(p=0.008), C-reactive protein (CRP) (p = 0.037), and
white blood cell (WBC) count (p=0.031). A significant correlation was
found between active sacroiliitis and SII (p=0.001), CRP
(p=0.000), erythrocyte sedimentation rate (ESR) (p=0.000), and
NLR (p=0.001). Based on the ROC curve analysis, SII was found to have a
sensitivity of 64.3% and specificity of 69.8%; NLR was found to
have a sensitivity of 64.3% and specificity of 73.3% for
diagnosing active sacroiliitis.
Conclusions Subclinical inflammation indices obtained from CBC and,
particularly, NLR may contribute to disease activity assessment like acute-phase
reactants. However, this needs to be confirmed in further studies.
Digitale Verfahren zur Behandlung psychischer Störungen in der COVID-19-Pandemie
Authors: Stricker Johannes , Lukies Rabea 
Published: May 2021

ZusammenfassungDie COVID-19-Pandemie und ihre Folgen (z. B. Kontaktbeschränkungen) stellen die psychiatrisch-psychotherapeutische Versorgung national und international vor neue Herausforderungen. Dieser Beitrag gibt einen Überblick über digitale Verfahren zur Behandlung psychischer Störungen unter Pandemiebedingungen und zur Reduktion pandemiebedingter psychischer Belastung (z. B. aufgrund sozialer Isolation). Diskutiert werden außerdem aktuelle Herausforderungen und Grenzen beim Einsatz digitaler Behandlungsformen sowie Perspektiven für deren langfristigen Einsatz in der psychiatrisch-psychotherapeutischen Versorgung.
The Functional Outcomes of Delayed Surgical Reconstruction in Nonsport-Induced Multiligament Knee Injuries: A Retrospective Cohort Study
Authors: Mortazavi S. M. Javad , Kaseb M. H. , Maleki R. G. , Razzaghof M. , Noori A. , Rezaee R. 
Published: May 2021

AbstractMultiligament knee injuries (MLKIs) are among the most detrimental injuries, which can cause significant compromise of joint stability and function. Our aim was to investigate the functional outcomes of nonsport-induced MLKIs who presented late after injury and underwent delayed arthroscopic reconstruction. In a retrospective cohort of 18 MLKI patients (19 knees, January 2012–2018) who had undergone arthroscopic reconstruction, we assessed the knee range of motion, return to work/sport, International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score, Western Ontario and McMaster Universities Arthritis Index, Lysholm, and Tegner scores. The preoperative scores were retrieved from the patients' registry database. We reviewed their surgical notes and extracted the operation data, including the damaged ligaments, stages of the surgery, and associated meniscal injury. There were 14 males and 4 females with a mean age of 30.57 ± 10.31 years. The mean time from injury to surgery was 17.31 ± 11.98 months. The most common injury was anterior cruciate ligament/posterior cruciate ligament (31.6%). The mechanisms of injury were motor vehicle accidents (72.2%), falls (22.2%), and sports (5.6%). The reconstruction was either single (61.2%) or multiple stage (38.8%). The pre- and postoperative scores were 45.31 ± 7.30 versus 79.16 ± 11.86 IKDC, 3.84 ± 1.26 versus 8.37 ± 1.16 Tegner, and 60.42 ± 7.68 versus 89.42 ± 8.81 Lysholm, respectively. All the scores showed significant improvement at mean follow-up of 24.05 ± 9.55 months (p < 0.001). In conclusion, delayed arthroscopic reconstruction of MLKIs significantly improved the functional outcomes and return to work in patients presenting late to the orthopaedic clinic. There was no relationship between the demographic variables, mechanism of injury, number of injured ligaments, and the stages of surgery and the functional outcomes in this group of patients.
What Parents of Adolescents in Residential Substance Use Treatment Want from Continuing Care: A Content Analysis of Online Forum Posts
Authors: Helseth Sarah A. , Scott Kelli , Escobar Katherine I. , Jimenez Frances , Becker Sara J. 
Published: May 2021

Background Parents of adolescents in residential substance use (SU) treatment face a myriad of barriers to continuing care services. Growing research suggests that mobile health (mHealth) technologies can overcome common barriers to continuing care services, yet no work has addressed parents’ needs. To gain insight into parents’ continuing care needs, we analyzed online forum posts made by parents who received a novel mHealth intervention. Methods Thirty parents received access to an online networking forum where they could connect with our adolescent SU expert or the community of parents also navigating their adolescent's post-discharge transition. In real-time, participants could ask questions and share information, experiences, and emotional support. Results Twenty-one parents (70%) posted at least once; 12 parents made 15 posts to our expert, while 18 parents made 50 posts to the parent community. Thematic analysis uncovered five major themes: parenting skills; parent support; managing the post-discharge transition; adolescent SU; and family functioning. Conclusions Parents discussed a range of topics directly and indirectly related to their adolescent's treatment. Incorporating networking forums into mHealth continuing care interventions offers parents a secure space to ask questions, share concerns, and gather information needed to support their adolescent's transition home.
Experimental Study on Impact Failure Characteristics of Large-size Boulder Specimen by SHPB
Authors: Cheng Jinguo , Jiang Hua , Jiao Xingfei , Jiang Yusheng , Zhu Jiachen 
Published: May 2021

Abstract
The issue of rock breaking is inevitable when shield excavating the strata rich in boulders with large size. Based on the one-dimensional elastic stress wave theory, the dynamic stress-strain relationship of rock specimens under single impact and cyclic impact load is obtained by using split Hopkinson pressure bar test system, and the variation law of absorbed energy with the changes of impact pressure or impact frequency is analyzed. The experiment results indicate that under single impact, when the impact pressure is added, the peak value of strain and stress increase; the dynamic elastic modulus of the specimen increases in the elastic stage, while increases at first and then decreases in the non-linear elastic loading stage. Also, the optimal impact energy exists corresponding to the maximum absorbed energy. Under the cyclic impact, the rock failure needs to meet the requirement of lowest impact energy. With the increase of impact pressure, the peak strain and single absorbed energy decrease at first and then increase, and the cumulative absorbed energy increases gradually. When the impact energy exceeds the energy required for rock failure, the rock is subject to primary impact failure. The research results can provide reference for the design of rock breaking cutters and the control of shield tunnelling parameters.