bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring data quality and use of the routine health information system in Ethiopia: a mixed-methods study
Authors:   The Operational Research and Coaching for Analysts (ORCA)- participants & team, Adane Abyot , Adege Tewabe M , Ahmed Mesoud M , Anteneh Habtamu A , Ayalew Emiamrew S , Berhanu Della , Berhanu Netsanet , Getnet Misrak , Bishaw Tesfahun , Busza Joanna , Cherinet Eshetu , Dereje Mamo , Desta Tsega H , Dibabe Abera , Firew Heven S , Gebrehiwot Freweini , Gebreyohannes Etenesh , Gella Zenebech , Girma Addis , Halefom Zuriash , Jama Sorsa F , Janson Annika , Kemal Binyam , Kiflom Abiy , Mazengiya Yidnekachew D , Mekete Kalkidan , Mengesha Magdelawit , Nega Meresha W , Otoro Israel A , Schellenberg Joanna , Taddele Tefera , Tefera Gulilat , Teketel Admasu , Tesfaye Miraf , Tsegaye Tsion , Woldesenbet Kidist , Wondarad Yakob , Yusuf Zemzem M , Zealiyas Kidist , Zeweli Mebratom H , Persson Lars Åke , Lemma Seblewengel 
Published: December 2021

ObjectiveA routine health information system (RHIS) enables decision making in the healthcare system. We aimed to analyse data quality at the district and regional level and explore factors and perceptions affecting the quality and use of routine data.DesignThis was a mixed-methods study. We used the WHO toolkit for analysing data quality and interviewed staff at the point of data generation and along with the flow of data. Data were analysed using the Performance of Routine Information System Management framework.SettingThis study was performed in eight districts in four regions of Ethiopia. The study was nested within a 2-year programme of the Operational Research and Coaching for government Analysts.ParticipantsWe visited 45 health posts, 1 district hospital, 16 health centres and 8 district offices for analysis of routine RHIS data and interviewed 117 staff members for the qualitative assessment.Outcome measuresWe assessed availability of source documents, completeness, timeliness and accuracy of reporting of routine data, and explored data quality and use perceptions.ResultsThere was variable quality of both indicator and data element. Data on maternal health and immunisation were of higher quality than data on child nutrition. Issues ranged from simple organisational factors, such as availability of register books, to intricate technical issues, like complexity of indicators and choice of denominators based on population estimates. Respondents showed knowledge of the reporting procedures, but also demonstrated limited skills, lack of supportive supervision and reporting to please the next level. We saw limited examples of the use of data by the staff who were responsible for data reporting.ConclusionWe identified important organisational, technical, behavioural and process factors that need further attention to improve the quality and use of RHIS data in Ethiopia.
Evaluation of the quality of contracted family doctor services based on patient perceptions and expectations: a follow-up analysis from the elderly with chronic diseases in rural Jiangsu, China
Authors: Jin Shengxuan , Wang Zhonghua , Tian Lanlan , Sun Zhenyu , Lin Zhenping , Qian Dongfu 
Published: December 2021

IntroductionThe policy focus of contracted family doctor services (CFDS) has been shifting to improve quality and efficiency in China. The study’s objective was to establish a quality evaluation scale for CFDS based on the perceived service quality model and to assess the service quality from the perspective of patient perceptions and expectations.MethodsData were obtained from a 2-year follow-up survey of CFDS in Jiangsu, China. A total of 1264 elderly people with chronic diseases were tracked. The self-developed scale was designed based on the perceived service quality model. The product scale method was used to assign weighted values, the Wilcoxon signed-rank test was used to compare the differences over the 2 years, and pooled cross-sectional regression was conducted to evaluate the associated factors with the gap scores of service quality.ResultsThere were significant differences between perceptions and expectations in each dimension in the 2 years (p<0.05), and the service quality gaps existed. Over the 2 years, Accessibility and Horizontal continuity were the first-ranked and second-ranked in expectations; the top three scores in perception were Horizontal continuity, Comprehensive service and Accessibility dimensions. The service quality gap in 2020 was smaller than that in 2019 (p<0.05). There were differences in the perception scores in the Vertical continuity, Technical and Economic dimensions and in the expectation scores in the Horizontal continuity, Vertical continuity and Technical dimensions between the 2 years (p<0.05). The factors that were significantly associated with each dimension score included the Jiangsu region, gender, age and education levels (p<0.05).ConclusionThe quality evaluation scale of CFDS has good reliability and validity. Policy efforts should be focused on accelerating the development of medical alliances, optimising medical insurance policies and improving the capacity of family doctor services to meet the needs of the elderly with chronic diseases.
Clinical decision-making for spinal manipulation for persistent spinal pain following lumbar surgery: a protocol for a systematic review and meta-analysis of individual participant data
Authors: Trager Robert James , Daniels Clinton J , Meyer Kevin W , Stout Amber C , Dusek Jeffery A 
Published: December 2021

IntroductionThere are limited available research and guidance regarding the use of spinal manipulative therapy (SMT) in patients with low back-related symptoms following lumbar spine surgery, a condition called persistent spinal pain syndrome type 2 (PSPS-2). This publication outlines a review protocol to identify and synthesise individual participant data (IPD) to examine associations between patient, clinical and surgical variables and SMT application in adults with PSPS-2.Methods and analysisPubMed, OVID, Web of Science, Scopus, PEDro, Index to Chiropractic Literature and KoreaMed will be searched from inception to 1 January 2022 without language restrictions. Case reports, series, observational studies and cases from grey literature of adults receiving SMT for PSPS-2 will be included. Two investigators will independently screen citations, abstracts and full-text articles. A risk-of-bias assessment will be performed in duplicate to rate cases according to exposure and outcome ascertainment and data completeness. Data extraction will be performed in duplicate and missing IPD will be requested from corresponding authors. Multiple binary logistic regression will be used to identify independent predictors of the use of lumbar–SMT, lumbar–manual-thrust SMT and SMT within 1-year postsurgery. Patient, clinical and surgical variables will be summarised using descriptive statistics, while SMT-related outcomes (lumbar–SMT, lumbar–manual-thrust SMT and 1-year surgery-to-SMT interval) will be described using adjusted ORs with 95% CIs.Ethics and disseminationThis study was deemed not human subjects research by the University Hospitals’ institutional review board. The results of this review will be disseminated at conferences and/or published in a peer-reviewed journal.PROSPERO registration numberCRD42021250039.
Parents’ attitudes as mediators between knowledge and behaviours in unintentional injuries at home of children aged 0–3 in Shanghai, Eastern China: a cross-sectional study
Authors: Ma Xueqi , Zhang Qi , Jiang Ruo , Lu Jun , Wang Huiping , Xia Qinghua , Zheng Jicui , Deng Wei , Chang Fengshui , Li Xiaohong 
Published: December 2021

ObjectiveParental behaviours are important in preventing unintentional injury at home among young children. Previous research showed an inconsistent relationship between knowledge and behaviours, indicating that the mechanisms may vary for different behaviours. This study aimed to examine the mediating roles of different attitudes in the mechanism of knowledge acting on different behaviours.DesignCross-sectional study.SettingEastern China.ParticipantsParticipants were recruited using stratified community-based sampling. A total of 488 parents of children aged 0–3 years participated in the study and 476 (97.5%) valid questionnaires were recovered.Primary outcome measuresParents’ knowledge, attitudes (including injury attribution, preventability and responsibility) and behaviours (including supervision behaviours, risky behaviours and providing a safe home environment).ResultsThe results of mediation analysis showed that the mediator variables were different for different behaviours and that all associations were positive. Parents’ knowledge (β 0.19, 95% CI 0.13 to 0.24) and attitude of injury attribution (β 0.37, 95% CI 0.21 to 0.46) were directly associated with risky behaviours. Attitude of preventability was directly associated with parents’ supervision behaviour (β 0.27, 95% CI 0.14 to 0.40). Parents’ attitude of preventability mediated the positive association between knowledge, attitudes of injury attribution and responsibility, and supervision behaviours, as well as providing a safe home environment. In addition, the occurrence of child injuries at home was directly associated with home environment (β −0.41, 95% CI −0.82 to −0.01).ConclusionsThe current findings confirm that attitudes play varying mediating roles between knowledge and different behaviours. An important recommendation is that parents’ attitudes, especially towards preventability and responsibility, need to be considered when health providers develop health education programmes targeted at improving parental supervision behaviours and providing a safe home environment.
Allogeneic haematopoietic stem cell transplantation—clinical outcomes: impact of leg muscle strength
Authors: Kondo Shin , Kagawa Kumiko , Saito Takashi , Oura Masahiro , Sogabe Kimiko , Harada Takeshi , Fujii Shiro , Nakamura Shingen , Miki Hirokazu , Sato Nori , Ono Rei , Abe Masahiro , Katoh Shinsuke 
Published: December 2021

ObjectivesMuscle strength decline is reported to predict mortality in many cancers. However, there is little knowledge of the relation between muscle strength decline and clinical outcomes of allogeneic haematopoietic stem cell transplantation (allo-HSCT). This study aimed to determine the impact of pre-transplant lower extremity muscle strength (LEMS) on post-transplant overall survival (OS) and non-relapse mortality (NRM).MethodsIn this retrospective cohort study, 97 adult patients underwent allo-HSCT during 2012–2020. LEMS was defined as knee extension force divided by patient’s body weight. The patients were divided into low and high LEMS groups based on pre-transplant LEMS. OS was measured using the Kaplan-Meier method and the Cox proportional hazards model. The cumulative incidence of NRM was evaluated using the Fine and Gray method, with relapse considered as a competing risk event.ResultsProbability of OS was significantly lower in the low LEMS groups (HR 2.48, 95% CI 1.20 to 5.12, p=0.014) than in the high LEMS group on multivariate analysis. Five-year OS was 25.8% and 66.4% in the low and high LEMS groups, respectively. Risk of NRM was significantly higher in the low LEMS group (HR 4.49, 95% CI 1.28 to 15.68, p=0.019) than in the high LEMS group. The cumulative incidence of NRM was 41.4% and 11.1% in the low and high LEMS groups, respectively.ConclusionsPre-transplant LEMS was a significant factor in predicting OS and NRM.
Patient-reported outcome measures suitable for quality of life/well-being assessment in multisectoral, multinational and multiperson mental health economic evaluations
Authors: Łaszewska Agata , Helter Timea Mariann , Nagel Anna , Perić Nataša , Simon Judit 
Published: December 2021

QuestionThe aim was to systematically collate and synthesise existing, publicly available patient-reported outcome measure (PROM) information suitable for quality of life (QOL)/well-being measurement in mental health economic evaluations, with specific focus on their applicability in multisectoral, multinational, multiperson economic evaluations and to develop an electronic PROM compendium with meta-data.Study selection and analysisA systematic literature search for non-disease-pecific PROMs and their versions suitable for the measurement of QOL/well-being or recovery was conducted from 2008 to February 2020. Six criteria were applied to judge their suitability in multisectoral, multinational, multiperson economic evaluations: (i) availability of separate adult and child/adolescent versions, (ii) availability of a proxy-completion option, (iii) assessing outcomes beyond health, (iv) availability of translations (≥2 language versions), (v) availability of a preference-based valuation, (vi) availability of value sets in more than one country.FindingsThe final ProgrammE in Costing, resource use measurement and outcome valuation for Use in multisectoral National and International health economic evaluAtions (PECUNIA) PROM-MH Compendium includes 204 unique scales, out of which 88 are individual instruments, while the remaining 116 scales belong to 46 PROM families with more than one distinctive version. Out of the total 134 individual PROMs/PROM families, 72% have at least two language versions, 8% measure broader well-being beyond health-related QOL, 11% have preference-based valuation, with multiple country sets available for 60% of these. None of the identified PROMs met all six proposed criteria.ConclusionsThe PECUNIA PROM-MH Compendium provides a unique overview of the relevant PROMs and their linked meta-data, and should be a helpful tool when choosing a suitable instrument for future mental health economic evaluations.
Trends in maternal body mass index in Northern Ireland: a cross-sectional and longitudinal study
Authors: Kent Lisa , Cardwell Christopher , Young Ian , Eastwood Kelly-Ann 
Published: December 2021

ObjectivesExplore (1) associations between maternal body mass index (BMI), demographic and clinical characteristics, (2) longitudinal trends in BMI, (3) geographical distributions in prevalence of maternal overweight and obesity.DesignRetrospective population-based study.SettingLinked, anonymised, routinely collected healthcare data and official statistics from Northern Ireland.ParticipantsAll pregnancies in Northern Ireland (2011–2017) with BMI measured at ≤16 weeks gestation.MethodsAnalysis of variance and χ2tests were used to explore associations. Multiple linear regression was used to explore longitudinal trends and spatial visualisation illustrated geographical distribution. Main outcomes are prevalence of overweight (BMI ≥25 kg/m2) and obesity (BMI ≥30 kg/m2).Results152 961 singleton and 2362 multiple pregnancies were included. A high prevalence of maternal overweight and obesity in Northern Ireland is apparent (singleton: 52.4%; multiple: 48.3%) and is increasing. Obesity was positively associated with older age, larger numbers of previous pregnancies and unplanned pregnancy (p<0.001). BMI category was also positively associated with unemployment (35% in obese class III vs 22% in normal BMI category) (p<0.001). Higher BMI categories were associated with increased rate of comorbidities, including hypertension (normal BMI: 1.8% vs obese III: 12.4%), diabetes mellitus (normal BMI: 0.04% vs obese III: 1.29%) and mental ill-health (normal BMI: 5.0% vs obese III: 11.8%) (p<0.001). Prevalence of maternal obesity varied with deprivation (most deprived: 22.8% vs least deprived: 15.7%) (p<0.001). Low BMI was associated with age <20 years, nulliparity, unemployment and mental ill-health (p<0.001).ConclusionsThe prevalence of maternal BMI >25 kg/m2is increasing over time in Northern Ireland. Women are entering pregnancy with additional comorbidities likely to impact their life course beyond pregnancy. This highlights the need for prioritisation of preconception and inter-pregnancy support for management of weight and chronic conditions.
Identifying patients with atrial fibrillation recurrences after two pulmonary vein isolation procedures
Authors: Mulder Bart A , Al-Jazairi Meelad I H , Magni Federico T , Groenveld Hessel F , Tieleman Robert G , Wiesfeld Ans C P , Tan Yong E S , Van Gelder Isabelle C , Rienstra Michiel , Blaauw Yuri 
Published: December 2021

IntroductionPulmonary vein isolation (PVI) is an important treatment for atrial fibrillation (AF). However, many patients need more than one procedure to maintain long-term sinus rhythm. Even after two PVIs some may suffer from AF recurrences. We aimed to identify characteristics of patients who fail after two PVI procedures.Methods and resultsWe included 557 consecutive patients undergoing a first PVI procedure with a second-generation 28 mm cryoballoon. Follow-up procedures were performed using radiofrequency ablation targeting reconnected PVs only. Recurrent AF was defined as any episode of AF lasting >30 s on ECG or 24 hour Holter monitoring performed at 3, 6 and 12 months post procedure. Mean age was 59.1±10.2 years, 383 (68.8%) were male, 448 (80.4%) had paroxysmal AF and the most common underlying condition was hypertension (36.6%). A total of 140/557 (25.1%) patients underwent redo procedure with PVI only. Of these patients 45 (32.4%) had recurrence of AF. These patients were comparable regarding age and sex to those in sinus rhythm after one or two procedures. Multivariate logistic regression showed that non-paroxysmal AF (OR 1.08 (95% CI 1.01 to 1.15), estimated glomerular filtration rate (OR 0.96, 95% CI 0.94 to 0.99), bundle branch block (OR 4.17, 95% CI 1.38 to 12.58), heart failure (OR 4.17, 95% CI 1.38 to 12.58) and Left Atrium Volume Index (OR 1.04, 95% CI 1.01 to 1.08) were associated with AF recurrence after two PVIs. The area under the curve for the identified risk factors was 0.74.ConclusionsUsing a PVI-only approach, recurrence of AF after two AF ablation procedures is associated with more advanced underlying disease and persistent types of AF.
Plasma adiponectin and risk of asthma: observational analysis, genetic Mendelian randomisation and meta-analysis
Authors: Nielsen Maria Booth , Nordestgaard Børge G , Benn Marianne , Çolak Yunus 
Published: December 2021

BackgroundAdiponectin, an adipocyte-secreted protein-hormone with inflammatory properties, has a potentially important role in the development and progression of asthma. Unravelling whether adiponectin is a causal risk factor for asthma is an important issue to clarify as adiponectin could be a potential novel drug target for the treatment of asthma.ObjectiveWe tested the hypothesis that plasma adiponectin is associated observationally and causally (using genetic variants as instrumental variables) with risk of asthma.MethodsIn the Copenhagen General Population Study, we did an observational analysis in 28 845 individuals (2278 asthma cases) with plasma adiponectin measurements, and a genetic one-sample Mendelian randomisation analysis in 94 868 individuals (7128 asthma cases) with 4 genetic variants. Furthermore, in the UK Biobank, we did a genetic two-sample Mendelian randomisation analysis in 462 933 individuals (53 598 asthma cases) with 12 genetic variants. Lastly, we meta-analysed the genetic findings.ResultsWhile a 1 unit log-transformed higher plasma adiponectin in the Copenhagen General Population Study was associated with an observational OR of 1.65 (95% CI 1.29 to 2.08) for asthma, the corresponding genetic causal OR was 1.03 (95% CI 0.75 to 1.42). The genetic causal OR for asthma in the UK Biobank was 1.00 (95% CI 0.99 to 1.00). Lastly, genetic meta-analysis confirmed lack of association between genetically high plasma adiponectin and causal OR for asthma.ConclusionObservationally, high plasma adiponectin is associated with increased risk of asthma; however, genetic evidence could not support a causal association between plasma adiponectin and asthma.
Quantum hall effects in two-dimensional electron systems: a global approach
Authors: Hidalgo M. A. 
Published: December 2021

AbstractUp to almost the last two decades all the experimental results concerning the quantum Hall effect (QHE), i.e. the observation of plateaux at integer or fractional (FQHE) values of the constant h/e2, were related to quantum-wells in semiconductor heterostructures. However, more recently, a renewed interest in revisiting these phenomena has arisen thanks to the observation of entirely similar effects in graphene and topological insulators. In this paper we show an approach encompassing all these QHEs using the same theoretical frame, entailing both Hall effect plateaux and Shubnikov-de Haas oscillations. Moreover, the model also enables the analysis of both phenomena as a function not only of the magnetic field but the gate voltage as well. More specifically, in the light of the approach, the FQHE in any two-dimensional electron system appears to be an effect of the breaking of the degeneration of every Landau level, n, as a result of the electrostatic interaction involved, and being characterized by the set of three integer numbers (n, p, q), where p and q have clear physical meanings too.
Pan-Sharpening for Spectral Details Preservation Via Convolutional Sparse Coding in Non-Subsampled Shearlet Space
Authors: Sangani Dhara J. , Thakker Rajesh A. , Panchal S. D. , Gogineni Rajesh 
Published: December 2021

The optical satellite sensors encounter certain constraints on producing high-resolution multispectral (HRMS) images. Pan-sharpening (PS) is a remote sensing image fusion technique, which is an effective mechanism to overcome the limitations of available imaging products. The prevalent issue in PS algorithms is the imbalance between spatial quality and spectral details preservation, thereby producing intensity variations in the fused image. In this paper, a PS method is proposed based on convolutional sparse coding (CSC) implemented in the non-subsampled shearlet transform (NSST) domain. The source images, panchromatic (PAN) and multispectral (MS) images, are decomposed using NSST. The resultant high-frequency bands are fused using adaptive weights determined from chaotic grey wolf optimization (CGWO) algorithm. The CSC-based model is employed to fuse the low-frequency bands. Further, an iterative filtering mechanism is developed to enhance the quality of fused image. Four datasets with different geographical content like urban area, vegetation, etc. and eight existing algorithms are used for evaluation of the proposed PS method. The comprehensive visual and quantitative results approve that the proposed method accomplishes considerable improvement in spatial and spectral details equivalence in the pan-sharpened image.