bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Antiplatelet agents in ischemic events
Authors: Shreen Sara , Baleeqh Uddin Mohammed , Ali Mir Salman , Sultana Zoha 
Published: August 2021

Antiplatelet treatment could be a key in pharmacological treatment for avoidance of coronary heart disease (CHD) and stroke. Depending on sign, term of antiplatelet monotherapy or double treatment is shifted. Antiplatelet treatment is shown to avoid a repeat of cardiovascular occasion, in any case, expanded term of dual antiplatelet treatment (DAPT) related with expanded hazard of bleeding. Unstable angina happens due to partially or totally block of the blood coronary blood vessel driving to coronary ischaemia. Intense coronary infection happens due to drawn out coronary ischaemia which causes coronary diseases.
Keywords: dual antiplatelet treatment (DAPT), coronary heart disease (CHD) and stroke.
Inhibitory effects of hydroethanolic extracts from three Cameroonian medicinal plants on proteins inflammation and growth of multi-resistant strains of Mycobacterium tuberculosis
Authors: Moni Esther Del florence Ndedi , Betote Patrick Hervé Diboue , Kom Christelle Wayoue , Benga Chimène Félicite Mekoulou , Tchamgoue Armelle Deutou , Nyegue Maximilienne Ascension 
Published: August 2021

The present work aimed to determine the phytochemical components and evaluate the in vitro anti-inflammatory and anti-mycobacterial effects of hydroethanolic extracts of Allium sativum L bulbs, Drypetes gossweileri S. MOORE stem-barks and Pentadiplandra brazzeana Baill roots against several resistant strains of Mycobacterium tuberculosis. The phytochemical screenings of extracts were carried out according the colorimetric and precipitation tests to reveal the presence of phytochemical compounds. The anti-inflammatory effects of extracts were evaluated using in vitro Bovine Serum Albumin denaturation and proteinase inhibitory action assays. The inhibitory parameters of hydro-ethanol extracts were evaluated by the microdilution method agaisnt Mycobacterium tuberculosis. The phytochemical screening of hydro-ethanol extracts revealed the presence of phenols, polyphenols, flavonoids, alkaloids, cathechic tannins, triterpens, steroids, anthocyanins and leucoanthocyanins. The anti-inflammatory activity of hydro-ethanol extracts of D. gossweileri, P. brazzeana and A. sativum have shown the inhibitory concentrations 50 (IC50) values ranging from 356.70, 183.30 and 226.30 mg/mL for BSA denaturation and 31.92, 33.62 and 56.93 mg/mL for proteinase inhibitory action respectively. The hydroethanolic extracts of D. gossweileri, P. brazzeana and A. sativum exhibited moderate and weak anti-mycobacterial activities with the minimum inhibitory concentrations (MICs) ranging from 312.5 to 2500 μg/mL. A. sativum hydro-ethanol extract has shown the highest anti-mycobacterial activity with MIC of 312.5 μg/mL against isoniazid resistant of M. tuberculosis and extremely resistant drug strain of M. tuberculosis. These results suggest that hydro-ethanol extracts of A. sativum, D. gossweileri and P. brazzeana are efficient against tuberculosis caused by multi-resistant Mycobacterium tuberculosis strains and are able to resorb the inflammation induced during infection.
Keywords: Anti-inflammatory activity, Anti-mycobacterial effect, Hydroethanolic extracts, Medicinal plants, Phytochemical screening.
A Case Study on the Effectiveness of Kabat Rehabilitation in a Patient with Bell’s Palsy
Authors: Dwivedi Bhawna , Chatterjee Apurva , Gujral Tanya 
Published: August 2021

One of the most prevalent neurological illnesses affecting the VII cranial nerve is paralysis of facial nerve. The loss of sophisticated and multidimensional capabilities such as expression of emotions via facial mimicry, face identification, and communication is caused by nerve paralysis. Through stimulation of the proprioceptors, the Kabat rehabilitation therapy for facial paralysis can trigger or restore the neuromuscular circuit, restoring the normal functionality of nerve terminals in the muscles.This study aims to show how a patient can gain functional & aesthetic benefits through detailed clinical evaluation followed by kabat rehabilitation. Functionality evaluation of the facial nerve was based on the SFGS,FDI and H- B scales Patients who were treated with kabat rehabilitation method restored motor capacities of the paralysed hemifacia.
Keywords: Kabat rehabilitation, facial nerve, facial palsy, proprioceptive facilitation, rehabilitation.
Proton pump inhibitors and peptic ulcer management: Antioxidant mechanisms
Authors: Alfahad Mohanad , Jasim Mahmood H M , Qazzaz Mohannad E , Alassaf Fawaz A , Abed Mohammed N 
Published: August 2021

Peptic ulcer (P.U.) is the gastrointestinal tract's most frequent disorder affecting mainly the stomach and duodenum. Surgical intervention, ingested materials and microbial infections may trigger inflammation that further predispose to oxidative stress. Proton pump inhibitors (PPIs) are group of compounds established for suppressions of gastric acid secretions profoundly and permanently over a reasonably long period of time. Oxidative stress has been shown to be involved in the pathophysiology of various diseases and disorders, including P.U. Particularly when H. pylori infection accompanies it. In addition to the colonization of this microorganism, gastric mucosa may be subjected to extreme oxidative stress with large levels of inflammatory cell aggregation, which may eventually predispose to the disorder. PPIs exert several effects other than gastric acid suppression that can be used to treat Helicobacter pylori infections, disorders of the respiratory tract, viral infections, and other conditions related to dysfunction of endothelium by activating endogenous antioxidant protection and reducing the release of cytokine. Recent therapeutic protocols have recommended PPIs as gastro-protective compounds not only because of their acid suppression properties, but also because of their potent antioxidant and anti-inflammatory properties.
Keywords: Proton Pump Inhibitors, Peptic Ulcer, Oxidative Stress, H. pylori
GCMS Profile of Bioactive Secondary Metabolites with Therapeutic Potential in the Ethanolic Leaf Extracts of Azadirachta indica¬: A Sacred Traditional Medicinal Plant of INDIA
Authors: Loganathan T. , Barathinivas A. , Soorya C. , Balamurugan S. , Nagajothi T. G. , Jayakumararaj R. 
Published: August 2021

Neem (Azadirachta indica) a member of Meliaceae plays an immense role in human health and disease which is attributed to its composition of Bioactive Secondary Metabolites (BASM). It has been widely used in Indian Traditional Systems of Medicine that includes Ayurveda, Siddha, Unani, Homeopathy and other Folklore Systems of Medicine practiced in the Indian Subcontinent for the treatment and prevention of various diseases. Current global health perspectives and medical practice in the post COVID era has no other way but to seek to merge alternative systems of medicine with evidence-based therapeutic aspects for a better understanding of the metabolic process and its effects in the human body. The studies based on animal model established that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular pathways including p53, pTEN, NF-κB, PI3K/Akt, Bcl-2, and VEGF. Besides, NEEM plays a vital role in the management of diabetics and its associated long term complication through ROS scavenging and ameliorative potentials to restore oxidative injury/ inhibit enzymes linked to. Overall NEEM is considered as GRAS medicinal plant that modulates metabolic inflammations without side effects. Though it has been confirmed that neem and its constituents play role in the scavenging of free radical and prevention of disease pathogenesis, a clear scientific basis of its pharmacoinformatics is still lacking. Gas Chromatography–Mass Spectroscopy (GC–MS) analysis of the fractions revealed the presence of 62 metabolites.
Keywords: Azadirachta indica; NEEM; GCMS; Bioactive Secondary Metabolites; GRAS; Medicinal Plants
A Case Report of Fungicial Poisoning
Authors: Rapolu Uma Malaika , Tarannum Nabeela , Bawani Enara , Danish Mohd 
Published: August 2021

Myclobutanil may be a conazole class fungicide. Mostly employed in food crops(like apple, banana, asparagus, beans, cranberry, grape, plum, soybean, tomato, strawberry) and in other commercial landscape. Moreover it’s lower acute toxicity is seen. In animal study, it can effect reproductive ability. Workers in fields are mostly affected. Common symptoms include headache, eye irritation, itching, nausea, vomiting, abdominal pain, nose bleeding. A 39 year old male patient was brought to emergency department with chief complaints nausea, vomiting, seizures, loss of consciousness, and nose bleeding. Patient was provided with treatment upon admission.
Keywords: Myclobutanil, conazole, fungicide.
Recent Patents on Modified Release Oral Dosage Forms
Authors: Pund Atul , Mundada Atishkumar , Magar Manoj , Kadam Abhijeet 
Published: August 2021

Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders.
Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong the release and hence action of the drug in the body.
Methods: Through this review, we throw the light on recent patents and patent applications on modified release systems pertaining to oral dosage forms. The various free patent search databases were used to collect and analyze the information on modified release delivery systems.
Results: Modified release systems such as extended release and delayed release delivery systems have been found to be of great significance due to their advantages over immediate release dosage forms. These systems are formulated using various approaches, different types of release controlling polymers such as natural, semisynthetic and synthetic polymers and found to avoid the limitations of conventional oral dosage forms.
Conclusion: Modified drug release systems have potential especially, in case of the chronic diseases, mental health disorders and lifestyle diseases and disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies.
Keywords: Modified release systems, extended release systems, controlled release systems, sustained release systems, delayed release systems, oral dosage forms, multilayer dosage form, multilayered tablets
Novel Application of Mixed Solvency Concept to Develop and Formulate Dry Powder Injection for Reconstitution of a Poorly Water Soluble Drug, Amlodipine Besylate and their Evaluations
Authors: Thakur Yashi , Maheshwari R.K. 
Published: August 2021

In the recent generation of pharmaceutical research, it has been observed that many newly designed and discovered drug products have less water solubility. Thus, leading to difficulties in several developmental, manufacturing and administrative processes. Furthermore, the clinical trials of these drugs have witnessed a great failure due to their poor pharmacokinetics. The lineup of our research work was promotion of mixed solvency concept by formulating the dry powder injection for reconstitution of poorly water-soluble drug amlodipine besylate by decreasing the solubilisers concentration in small proportion for expected synergistic enhancement of drug solubility in water. Solubilisers used are sodium benzoate, sodium caprylate, PVPK-25, sodium citrate, niacinamide, poloxamer 407, sodium acetate, L-arginine, benzoic acid, β-cyclodextrin and lysine hydrochloride to developed the dry powder injection for reconstitution of amlodipine besylate. The reconstitution time of amlodipine besylate injections were found 58 sec, 36 sec and 1 min 10 sec in selected blends. This drug is slightly soluble in water, and it comes in various forms, including tablets and other oral dosage forms. However, no amlodipine besylate dry powder injection or ready-made injections are currently available in the market. Dry powder injection for reconstitution of amlodipine besylate was formulated successfully and mixed solvency concept has been successfully employed.
Keywords: Mixed solvency concept, Amlodipine besylate, Dry powder injection for reconstitution, Solubilisers, Solubility.
Aplikasi Metode Simpleks Pada Optimalisasi Biaya Bahan Baku (Studi Kasus: Ukm Najmah Klappertart)
Authors: Damayanti D , Jaya A I , Resnawati  
Published: August 2021

ABSTRACT
The purpose of this research is to obtain an the optimal production costs of Klappertart based on the basic ingredients comparing the production cost of Klappertart in Najmah Klappertart with production costs using the simplex method. The result showed that the optimal costs is ,-. This result is equal to the total cost of klappertart by SMEs Najmah Klappertart, so it can be concluded that the cost of production klappertart based on the basic ingredients on SMEs Najmah Klappertart were optimal.
Keywords : Optimal Cost, Basic Ingredients, Production Costs. (A-Z), Simplex Method
Optimalisasi Biaya Transportasi Pendistribusian Pupuk Bersubsidi Menggunakan Model Transportasi Metode Modified Distribusition (MODI)
Authors: Pertiwi N , Jaya A I , Hajar  
Published: August 2021

ABSTRACT
This study was conducted to obtain the optimal transport costs in the distribution of subsidized fertilizer in PT. GCS and PT.PPI. This research was done in two steps is to create a transport model of the data obtained and determine its solution initially with Least Cost method, and determine the optimal solution with ModifiedDistribution (MODI) method. Based on research that obtained the initial solution is Rp. 65.040.000 and optimal solution is Rp. 64.950.000. While the cost of transportation from the company is RP. 70.500.000. This shows that both distributors can optimize the total cost of transport for the distribution of subsidized fertilizer in January 2017 with the distribution cost savings of Rp. 5.550.000.
Keywords : Least Cost Method, Modified Method of Distribution, Optimization, Transportation
Kendali Optimal Model LCS Pada Populasi Tanaman Padi Sawah Dari Serangan Hama Tikus Sawah Dan WBC Menggunakan Prinsip Minimum Pontryagin
Authors: Triwidodo G , Ratianingsih R , Nacong N 
Published: August 2021

ABSTRACT
Rice field plants (Oryza sativa) is one of the main food crop that very essential for common poeple. On the other hand, rice become as the main commodity of the common poeple. According to Badan Pusat Statistik ( BPS ) data, the consumption of it in 2011 reached 139 kg of due to 237 million of Indonesian resident. The cultivation of rice field production obstacle is the pest attack. The able prime pest that caused the rice production damage is field mouse pest (Rattus argintiventer) and rice stem pest (Nilaparvata Lugens). Both types have a very high reproduction rate. This research studies mathematically the damage of rice field plants population control at vegetative phase. That designed to minimize the number of vegetative rice population phase. A logistic Competing Species model is built to describe the interaction between both the pest at the vegetative phase rice growth. The Pontryagin minimum principles is used to determine the optimal control solution. The solution is solved from the state and co-state equation that stationery evaluated using the indexed performance with optimal control and . The research result of indicate that the optimal control just optimalize the vegetative rice phase damage while the pest is not optimalized yet.
Keyword : Stability, Jacoby Matrix, Eigen Value, Pontryagin Minimum, Oryza Sativa, Rattus Argintivente, Nilaparvata Lugens
Merancang Alat Pendeteksi Boraks Pada Bakso Menggunakan Metode Logika Fuzzy Berdasarkan Sensor Warna Dan LED (Light Emitting Diode) Berbasis Android
Authors: Turilah N H , Sudarsana I W , Lusiyanti D 
Published: August 2021

ABSTRACT
Meatballs are foods made from meat, shrimp, fish chopped and crushed together with starch and egg white, usually formed roundly. Meatballs have health benefits for the human body because of the content contained in animal protein, vitamins and fat. However, in the manufacture of meatballs for the benefit of many, sellers often use the wrong way by using borax chemicals on meatballs. Therefore, this study aims to build a design tool in the form of borax detection on meatballs based on android. The tool works by processing the input data obtained from a color sensor coupled with an LED (Light Emitting Diode) to the microcontroller on Arduino Uno R3. The data is processed by implementing the Mamdani fuzzy logic method as a decision to state the output output of borax detector on meatballs. Furthermore, the output output displayed on the device using a sample of 12 meatballs obtained tool accuracy of 75%.
Keywords : Boraks, Color Sensor, Fuzzy Logic, Microcontroller, Meatball.
Penentuan Jalur Terpendek Pendistribusian Barang Jalur Nugraha Ekakurir (JNE) Menggunakan Algoritma Semut (Studi Kasus JNE Dewi Sartika Palu)
Authors: Musdalipa  , Sahari A , Najar A M 
Published: August 2021

Nowasday, it is often done traveling from one place or location to another by considering the path or the shortest route to be traveled. In determining the shortest route by implementing the ant algorithm to determine the shottest route. This case is a case of the traveling salesmen problem (TPS) namely visiting all location points starting from the starting point and ending at the starting point again. Case study in this research is delivery data of JNE courier palu. The sample used is 13 points which are then resolved using the ant algorithm adopts the ant work method to get the shortest route. The use of the ant algorithm in this case is limited to one cycle or one iteration (NC=1) so that the best route for the first cycle is obtained JNE Gudang utama dewi sartika palu( JNE jalan banteng No.8a biromaru palu selatan ( JNE basuki rahmat ( ), JNE jalan anoa No.107 pau selatan ( JNE diponegoro lere palu barat( JNE emysaelan No.20 palu selatan ( JNE sisingamangaraja palu ( JNE jalan kimaja palu barat ( ), JNE krajalemba No.7 sigi biromaru ( JNE jalan tombolotutu palu JNE samratulangi No.66 A palu ( ), JNE tondo kamus mantikulore ( JNE diponegoro lere palu barat ( anddcome back to JNE gudang utama dewi sartika palu ( ) with a distance of 56.4 km.
Perancangan Sistem Kontrol Ketinggian Air Sawah Berdasarkan Usia Tanaman Padi Menggunakan Arduino Mega 2560
Authors: Apriyunike Widia , Sardi Juli 
Published: August 2021

Pengaturan ketinggian air merupakan faktor yang sangat penting dalam pertumbuhan dan perkembangan tanaman padi. Salah satu permasalahan yang dihadapi oleh petani saat ini adalah mengalami kesulitan dalam mengatur ketinggian air sawah karena sering kali petani pulang pergi dari rumah kesawah hanya untuk membuka dan menutup saluran air. Penelitian ini bertujuan untuk membuat perancangan sistem kontrol ketinggian air secara otomatis sesuai dengan kebutuhan air berdasarkan usia tanaman padi. penelitian ini membuat prototipe yang terdiri dari software arduino IDE untuk pengkodean sistem dan hardware yang dilengkapi dengan arduino mega 2560, sensor water level, motor servo, real time clock (RTC), tombol push button, driver relay, pompa air, dan LCD. Setelah dilakukan beberapa percobaan, semua bagian dalam sistem ini mampu bekerja sesuai dengan tujuan penelitian. Alat ini bisa menjadi salah satu alternatif yang bisa diterapkan oleh petani untuk mengatur ketinggian air sawah.
Alat Monitoring Beban Trafo Tiga Phasa Menggunakan Arduino Berbasis Web
Authors: Nasution Ali Usman , Sukardi Sukardi 
Published: August 2021

Listrik sudah merupakan menjadi kebutuhan sekunder manusia, yang dimana segala segi kehidupan manusia sudah terkoneksi ke listrik. Maka dari itu pada pendistribusian energy listrikke konsumen harus slalu terjaga ke stabilannya. Padasaat pendistribusian energy listruk, gangguan yang sering terjadi adalah gangguan ketidakstabilan beban pada trafo, gangguan ini akan megakibatkan mangalirnya arus pada penghantar netral, dan lebih parah akan mengkibatkan kerusakan pada transformator itu sendiri. Maka oleh karena itu, perlu dibuat suatu alat monitoring beban trafo berbasis mikrokontroler berbasis web, sehingga jika terjadi ketidak stabilan beban akan bisa dengan cepat dapat dideteksi. Dan ini akan menghemat waktu dalam pemonitoringan beban transformator yang masih dilakukan secara langsung ke tempat transformator tersebut dengan jadwal yang telah ditentukan. Sensor sct013 yang dipasang pada trafo tersebut akan membaca arus dan sensor zmpt101b akan membaca tegangan dari trafo tersebut, dan hasil pembacaan tersebut akan di diolah oleh arduino mega 2560, hasil dari pengolahan tersebut akan di tampilkan dalam lcd berupa tanggal, tegangn, arus, dan daya. Selain itu hasil dari pembacaan sensor yang telah di olah arduino ini dikirim ke database yang telah dibauat. Proses pengiriman data dari arduino ini dilakukan oleh modul esp8266-01 yang telah di konfigurasi dengan arduino. Sehingga pemonitoringan beban trafo bisa di lihat kapan pun di website alinasution.epizy.com.
Sistem Keamanan Sepeda Motor Berbasis Internet of Things
Authors: Ikhsan Ikhsan , Elfizon Elfizon 
Published: August 2021

Seiring dengan perkembangan zaman pada saat ini, maka kebutuhan masyarakat pada alat transportasi sangat meningkat, salah satunya adalah kendaraan sepeda motor. Semakin meningkat nya alat transportaasi pada saat ini juga sangat mempengaruhi kasus pencurian kendaraan sepeda motor yang akan ikut meningkat. Kasus kejahatan pencurian kendaraan seperti ini masih sering terjadi dikarenakan kurangnya alat sistem keamanan pada kendaraan sepeda motor. Tugas Akhir ini membahas Sistem Keamanan Sepeda Motor Berbasis Internet of Things untuk mengirimkan koordinat sepeda motor tersebut dan dapat menampilkan google maps untuk melihat dimana keberadaan sepeda motor tesebut. Pemanfaatan teknologi Internet of Things pada keamanan kendaraan sepeda motor merupakan solusi yang sangat bagus, dikarenakan sistem seperti ini dapat menjadi solusi sebenarnya dari masalah keamanan pada kendaraan. Dengan memanfaatkan Internet of Things, pemilik kendaraan bisa melacak lokasi kendaraan sepeda motornya dimanapun berada. Manfaat nyata adanya teknologi Internet of Things adalah semakin efektif dan efisien tata kelola di berbagai bidang. Selain itu diharapkan di masa mendatang harga teknologi ini semakin terjanngkau oleh masyarakat.