bluuebunny/crossref_metadata_2025_split huggingface dataset:
The physiological and proteomic characteristics of oilseed rape stem affect seed yield and lodging resistance under different planting densities and row spacing
Authors: Kuai Jie , Li Xiaoyong , Ji Jianli , Li Zhen , Xie Yan , Wang Bo , Zhou Guangsheng 
Published: August 2021

AbstractLodging is an important factor that restricts the yield of rapeseed and the mechanical harvesting. To explore agricultural practise and mechanisms that can synergistically improve the rapeseed yield and lodging resistance, a conventional plant type HZ 62 was selected in 2016–2017, and HZ 62 and an erect‐leaf type 1,301 were grown in 2017–2018. The planting density was set as main plots at 15 × 104 plants ha1 (D1), 30 × 104 plants ha‐1 (D2) and 45 × 104 plants ha−1 (D3), with the row spacing as sub‐plots of 15 cm (R15), 25 cm (R25) and 35 cm (R35). The results showed that with increased density and narrowed row spacing, the radiation utilisation efficiency (RUE) of the population and seed yield were greatly increased. Compared with that at D1R25, the yield of HZ 62 at D3R15 was increased by 19.00% and 22.53%, respectively, in 2016–2017 and 2017–2018, whereas the yield of 1,301 rose by 31.98%. The influence of the RUE on the seed yield reached the peak at flowering stage. With increased planting density and narrowed row spacing, the lodging index of HZ 62 declined. The lodging index of 1,301 was increased with higher density and declined with narrowed row spacing. Compared with D1R25, the averaged lodging index across different parts of HZ 62 at D3R15 declined by 15.03% and 10.80%, respectively, in 2016–2017 and 2017–2018, and that of 1,301 was increased by 25.47%. Compared with D1R25, the stem proteomics during the flowering stage showed the expression of photosynthesis‐related proteins (A0A078FHG9, A0A078JZM9 and A0A078JQI2) up‐regulated, that consistent with Rubisco, SPS and FBPase activities; proteins related to phenylpropanes metabolism, A0A078IWR4 of HZ 62 and A0A078JWZ9 of 1,301 increased that consistent with POD activity, which resulted in more sucrose, starch and lignin in the stem at D3R15. Moreover, the protein related to cellulose synthesis (A0A078I4D9), the activity of β‐1,3‐glucanase and content of cellulose in the stem were up‐regulated in HZ 62 but down‐regulated in 1,301, contrary to the variation in the stem lodging index. The cellulose synthesis differed between the varieties in different treatment combinations of planting density and row spacing. This was the key process by which planting density and row spacing influence the lodging of rapeseed varieties with varied plant architecture.
Clinical impact of medication adherence on 10‐year cardio‐cerebrovascular mortality in newly diagnosed hypertensive patients
Authors: Kim Cho‐Long , Do Yoon‐Sung , Kim Byung‐Jun , Lee Kyeong‐Soo , Nah Min‐Ah , Kim Ung , Lee Jung‐Hee , Hwang Tae‐Yoon 
Published: August 2021

AbstractThe purpose of this study is to evaluate the impact of medication adherence on cardio‐cerebrovascular (CCV) mortality in newly diagnosed hypertensive patients. The authors retrospectively reviewed data from 20,836 patients who newly diagnosed hypertension from January 1, 2003 to December 31, 2005. Medication adherence was calculated from the compliance ratio (CR) during the first year after the diagnosis of hypertension. CCV mortality for 10 years was assessed according to the presence or absence of complications of hypertension. The risk of CCV death was significantly reduced in the CR ≥ 70% group than in the CR < 70% group (hazard ratio, 0.70; p = .004) for 10 years. In the patients without complications, the risk of CCV death was significantly lower in the CR ≥ 70% group than in the CR < 70% group (hazard ratio, 0.56; p = .014). However, in patients with complications, there was no significant difference in risk of CCV death between the CR ≥ 70% group and the CR < 70% group (hazard ratio, 0.79; p = .100). Only the CR ≥ 90% group had a significantly lower risk of CCV death (hazard ratio, 0.56; p < .001) for those with complications. Medication adherence is significantly associated with CCV mortality during 10 years in newly diagnosed hypertensives patients. Patients with complications of hypertension have to continue a high adherence rate (CR ≥ 90) for better long‐term clinical outcomes.
Patterns of delay in early gross motor and expressive language milestone attainment in probands with genetic conditions versus idiopathic ASD from SFARI registries
Authors: Wickstrom Jordan , Farmer Cristan , Green Snyder LeeAnne , Mitz Andrew R. , Sanders Stephan J. , Bishop Somer , Thurm Audrey 
Published: August 2021

BackgroundRecent large‐scale initiatives have led to systematically collected phenotypic data for several rare genetic conditions implicated in autism spectrum disorder (ASD). The onset of developmentally expected skills (e.g. walking, talking) serve as readily quantifiable aspects of the behavioral phenotype. This study's aims were: (a) describe the distribution of ages of attainment of gross motor and expressive language milestones in several rare genetic conditions, and (b) characterize the likelihood of delays in these conditions compared with idiopathic ASD.MethodsParticipants aged 3 years and older were drawn from two Simons Foundation Autism Research Initiative registries that employed consistent phenotyping protocols. Inclusion criteria were a confirmed genetic diagnosis of one of 16 genetic conditions (Simons Searchlight) or absence of known pathogenic genetic findings in individuals with ASD (SPARK). Parent‐reported age of acquisition of three gross motor and two expressive language milestones was described and categorized as on‐time or delayed, relative to normative expectations.ResultsDevelopmental milestone profiles of probands with genetic conditions were marked by extensive delays (including nonattainment), with highest severity in single gene conditions and more delays than idiopathic ASD in motor skills. Compared with idiopathic ASD, the median odds of delay among the genetic groups were higher by 8.3 times (IQR 5.8–16.3) for sitting, 12.4 times (IQR 5.3–19.5) for crawling, 26.8 times (IQR 7.7–41.1) for walking, 2.7 times (IQR 1.7–5.5) for single words, and 5.7 times (IQR 2.7–18.3) for combined words.ConclusionsDelays in developmental milestones, particularly in gross motor skills, are frequent and may be among the earliest indicators of differentially affected developmental processes in specific genetically defined conditions associated with ASD, as compared with those with clinical diagnoses of idiopathic ASD. The possibility of different developmental pathways leading to ASD‐associated phenotypes should be considered when deciding how to employ specific genetic conditions as models for ASD.
A Japanese patient with a 2p25.3 terminal deletion presented with early‐onset obesity, intellectual disability and diabetes mellitus: A case report
Authors: Sakaue Taka‐aki , Obata Yoshinari , Fujishima Yuya , Kozawa Junji , Otsuki Michio , Yamamoto Toshiyuki , Maeda Norikazu , Nishizawa Hitoshi , Shimomura Iichiro 
Published: August 2021

ABSTRACT2p25.3 deletion syndrome is a rare genetic disorder that accompanies various phenotypic features, including early‐onset obesity and intellectual disability. Here, we report the first Japanese case of this deletion associated with severe obesity and diabetes mellitus. Microarray‐based comparative genomic hybridization analysis identified a 3.1‐Mb deletion of distal chromosome band 2p25.3, which was suspected as de novo. The patient also presented bilateral cataracts and adolescent‐onset muscular weakness of the upper limbs, both of which were uncommon in previously reported cases. It is possible that these symptoms are also important clinical features suggestive of this syndrome.
Using recombinase‐mediated cassette exchange to engineer MIN6 insulin‐secreting cells based on a newly identified safe harbor locus
Authors: Furukawa Asami , Tanaka Aya , Yamaguchi Suguru , Kosuda Minami , Yamana Midori , Nagasawa Akiko , Kohno Genta , Ishihara Hisamitsu 
Published: August 2021

AbstractAims/IntroductionRecent studies have identified genomic and transcript level changes along with alterations in insulin secretion in patients with diabetes and in rodent models of diabetes. It is important to establish an efficient system for testing functional consequences of these changes. We aimed to generate such a system using insulin‐secreting MIN6 cells.Materials and MethodsMIN6 cells were first engineered to have a tetracycline‐regulated expression system. Then, we used the recombination‐mediated cassette exchange strategy to explore the silencing‐resistant site in the genome and generated a master cell line based on this site.ResultsWe identified a site 10.5 kbps upstream from the Zxdb gene as a locus that allows homogenous transgene expression from a tetracycline responsible promoter. Placing the Flip/Frt‐based platform on this locus using CRISPR/Cas9 technology generated modified MIN6 cells applicable to achieving cassette exchange on the genome. Using this cell line, we generated MIN6 subclones with over‐ or underexpression of glucokinase. By analyzing a mixed population of these cells, we obtained an initial estimate of effects on insulin secretion within 6 weeks. Furthermore, we generated six MIN6 cell sublines simultaneously harboring genes of inducible overexpression with unknown functions in insulin secretion, and found that Cited4 and Arhgef3 overexpressions increased and decreased insulin secretion, respectively.ConclusionsWe engineered MIN6 cells, which can serve as a powerful tool for testing genetic alterations associated with diabetes, and studied the molecular mechanisms of insulin secretion.
Photovoice as a tool to improve patient—Provider communication in inflammatory bowel disease clinic: A feasibility study
Authors: Gorbenko Ksenia O , Riggs Alexa Rae , Koeppel Brooke , Phlegar Sydney , Dubinsky Marla C , Ungaro Ryan , Keefer Laurie 
Published: August 2021

AbstractBackgroundThe emotional health of patients with inflammatory bowel disease (IBD) is critical to self‐management, but has been difficult to elucidate in routine care. Patients are often unsure how to communicate their preferences and concerns to their providers in ways that could directly inform shared decision making. Photovoice is an established research methodology used to give vulnerable patients a voice through photographic expression, but has not been previously used in gastroenterology or in IBD.ObjectiveTo determine the acceptability and feasibility of using Photovoice in an IBD clinic.Patient involvementPatients with IBD took photos in response to open‐ended prompts, participated in a focus group, and brainstormed ways to share their experience with clinicians.MethodsEnrolled IBD patients received a digital camera, training on basic usage and 10 open‐ended prompts related to management of their IBD. Participants completed one‐hour in‐depth interviews about their photos, which were audio‐recorded and professionally transcribed. Three analysts coded transcripts for themes using qualitative analysis software QSR NVivo 11. A subset of patients participated in a focus group about their Photovoice experience. Gastroenterologists were interviewed, using patient photos as prompts, to evaluate feasibility of using Photovoice in the clinic.ResultsEleven patients completed the interviews, with five participating in the focus group. Patients shared and discussed a total of 118 photographs. We identified two major themes: disease burden and patient ‐ provider communication. Five IBD physicians reviewed select patient photos and suggested ways to incorporate Photovoice into clinical practice.DiscussionPhotovoice may be a feasible methodology for patients with IBD and acceptable for providers to use in a clinical setting.Practical valuePhotovoice may help providers identify patient concerns and make their communication more patient‐centred.
Method for acquiring accurate coordinates of the source point in electron backscatter diffraction
Authors: Zhang Yongsheng , Shen Yitian , Peng Fan , Jiang Caifen , Li Wei , Miao Hong , Huang Fuqiang , Zeng Yi 
Published: August 2021

AbstractAn electron backscatter diffraction device is an important accessory for a scanning electron microscope and can provide crystal structure orientation and phase content data through analysis of electron backscatter diffraction patterns. The acquisition of these data depends on pattern indexing, including interplanar angle calculation and crystal plane indexation. The coordinates of the source point are key points for interplanar angle calculation, and they vary with the movement of the incident beam. In this study, we first combined the grey gradient calculation with screen moving method to achieve accurate positioning of source point and obtained coordinates of source point with sub‐pixel precision. The errors of three coordinates were 0.07%, 0.06% and 0.04%, respectively. By using this coordinate of source point to conduct interplanar angle calculation the maximum error was 0.53°, which was a good proof of the accuracy of source point positioning. Then we established the relationship between source point coordinates variation and incident beam movement. Coordinates can be given out based on the displacement of beam directly. And to illustrate the accuracy, interplanar angle calculation was performed and the maximum error was 0.81°. This means that the relationship between variation of source point coordinates and beam movement is highly accurate.
Self‐cosmetic care during the COVID‐19 pandemic and its psychological impacts: Facts behind the closed doors
Authors: Marahatta Suchana , Singh Aditi , Pyakurel Prajjwal 
Published: August 2021

AbstractBackgroundCoronavirus disease (COVID‐19) pandemic has resulted in significant negative psychological impacts in our life. Not doing adequate cosmetic care of skin, hair, and nails might be one of the underexplored but preventable reasons for the same.AimsTo identify the change in cosmetic care habits of female undergraduate medical students during the coronavirus disease pandemic and to identify its psychological impacts on them.MethodsA total of 218 individuals participated in this online study. Data were collected using a preset pro forma as a Google questionnaire to fulfill the objectives. Data were analyzed using SPSS version 11.5 and presented as percentage, mean, SD, median, IQR in tables and graphs.ResultsMean age of the participants was 21.56 ± 1.95 years. Maximum respondents (66.0%) are not taking cosmetic care of skin, hair, and nail during the pandemic as before. More than two‐thirds (68.8%) are feeling bad, 31.2% are neutral, whereas none are feeling good because of this change. Second‐year students and the participants from rural locations are taking least cosmetic care (p < 0.05). However, coronavirus disease infection and major life events in the family did not affect it. Nail care was prioritized by the maximum (64.2%). Of all participants who are not doing cosmetic care as before, a maximum (50.0%) had lost self‐satisfaction followed by increased irritability (43.8%).ConclusionsA huge number of female medical students are not doing cosmetic care of their skin, hair, and nail during the coronavirus disease lockdown; they also perceive significant negative psychological impact because of this change.
Dividend decisions in family businesses: A systematic review and research agenda
Authors: Molly Vincent , Michiels Anneleen 
Published: August 2021

AbstractDividend policy in family businesses has been studied in multiple disciplines within the past two decades. Despite strong growth in this research, both contradictory findings and research gaps were found. This study systematically reviews 47 articles on dividend decisions in family businesses, published between 2001 and 2020 in a wide variety of finance, economics, and management journals. Based on a comprehensive analysis, we provide an overview of the current state in family business literature structuring theoretical thinking on dividend decisions. In addition, we offer a research agenda for the future, containing specific suggestions on research questions, theoretical integration, sampling, and study design. This way, we articulate and spotlight areas where family business and finance scholars may most fruitfully direct their attention, which will in turn advance our knowledge of dividend decisions in family businesses.
Fracture Resistance of Single‐Unit Implant‐Supported Crowns: Effects of Prosthetic Design and Restorative Material
Authors: Donmez Mustafa Borga , Diken Turksayar Almira Ada , Olcay Emin Orkun , Sahmali Sevil Meral 
Published: August 2021

AbstractPurposeTo evaluate the fracture resistance and fracture patterns of single implant‐supported crowns with different prosthetic designs and materials.Materials and MethodsOne hundred and forty‐four identical crowns were fabricated from zirconia‐reinforced lithium silicate (ZLS), leucite‐based (LGC), and lithium disilicate (LDS) glass‐ceramics, reinforced composite (RC), translucent zirconia (ZR), and ceramic‐reinforced polyetheretherketone (P). These crowns were divided into 3 subgroups according to restoration design: cementable crowns on a prefabricated titanium abutment, cement‐retained crown on a zirconia‐titanium base abutment, and screw‐cement crown (n = 8). After adhesive cementation, restorations were subjected to thermal‐cycling and loaded until fracture. The fracture patterns were evaluated under a stereomicroscope. Statistical analysis was performed by using 2‐way ANOVA/Bonferroni multiple comparison post hoc test (α = 0.05).ResultsFor each prosthetic design, ZR presented the highest fracture resistance (p ≤ 0.005). Other than the differences with ZLS and RC for screw‐cement crowns (p > 0.05) and RC for crowns on zirconia‐titanium base abutments (p > 0.05), LGC showed the lowest fracture resistance. P endured higher loads than LDS (p < 0.001), except for the crowns on zirconia‐titanium base abutments (p > 0.05). Cementable crowns presented the highest fracture resistance (p < 0.001), other than LGC and LDS. The differences between LGC crowns (p > 0.05) or LDS crowns on prefabricated titanium and zirconia‐titanium abutments were nonsignificant (p = 0.133). Fragmented crown fracture was predominant in most of the restorations. Screw and abutment fractures were observed in ZR screw‐cement crowns, and all P crowns were separated from the abutments.ConclusionsRestorative material and restoration design affect the fracture resistance and fracture pattern of implant‐supported single‐unit restorations. Clinicians may restore single‐unit implants in premolar sites with the materials and prosthetic designs tested in the present study.
Local job multipliers revisited
Authors: Osman Taner , Kemeny Tom 
Published: August 2021

AbstractThere has been a recent surge in papers estimating local multiplier effects. However, existing studies rely on arbitrary periods of observation, limit samples to more populous regions, and commonly use relatively aggregated industrial categories. When we address these and other methodological issues, we find that, in the United States, each new traded sector job adds half a nontraded job to a local economy, and that the addition of each high‐tech job adds less than one job to the local nontraded sector. Furthermore, we find that the multiplier effect of the manufacturing sector is no higher than the multiplier effect of the average traded sector. We provide robust evidence that higher‐paying traded sectors yield more nontraded jobs than lower paying sectors, and that multiplier effects are higher in larger cities. Furthermore, we generate IV estimates that remedy weak instrument problems in the existing multipliers literature. These findings offer needed clarity on the likely employment impacts of incentive policies aimed at attracting industries in the traded sector of the economy.
Action Research on Meaning‐Making at Residents' Meetings for Local Disability Policy1
Authors: Tagaki Masakuni 
Published: August 2021

AbstractThis is the third in a series on residents' meetings (RMs) for municipal disability policymaking in Japan; members included people with disabilities (PWDs). I focused on members' meaning‐making process for three community organizational goals: task, process, and relationship. Action research was employed in all three studies during my participation in RMs, which began in 2002. The present study is a follow‐up on the meetings' development and covers 2013 to 2019. Meetings were divided into three phases: (a) use of the annual symposium to inform a broader audience about disability policies; (b) appreciation that PWDs can play active roles as supporters of others, especially other PWDs; and (c) recognition that contradiction and dilemma are present in attempts to provide “universal” social equipment for social minorities. The three goals were interrelated through uncertainty and vagueness of RMs; however, it enabled the members to interpret their multifaceted disability‐related experiences. PWDs realized their power to help others and developed disability identities through intensive discussions, while they realized the difficulty of social acceptance of their power and the limited solidarity among PWDs.
Test of the Serotonin Transporter Gene × Early Life Stress Interaction Effect on Subjective Well‐Being and Loneliness Among Japanese Young Adults
Authors: Ohtsubo Yohsuke , Matsunaga Masahiro , Masuda Takahiko , Noguchi Yasuki , Yamasue Hidenori , Ishii Keiko 
Published: August 2021

AbstractThis study investigated whether aspects of early life environment (quality of parental relationship, frequency of parental violence including disciplinary violence, amount of parental attention, and family income during childhood) would affect one's subjective well‐being and loneliness later in life (i.e., during young adulthood). This study also investigated whether the negative influence of early life stress is greater among individuals with the SS genotype of the serotonin transporter‐linked polymorphic region (5‐HTTLPR) in the serotonin transporter gene. Participants were 568 university students whose genotypes were identified using nail samples. They reported their current levels of subjective well‐being and loneliness as well as their recollections of their early family environments. The results showed that less stressful early life environments, such as high levels of parents' relationship quality and parental attention, were positively (negatively) associated with subjective well‐being (loneliness), while frequent parental violence was negatively (positively) associated with subjective well‐being (loneliness). Nevertheless, the gene × environment interaction effects were consistently non‐significant—the SS genotype did not accentuate the effects of early life stress.
Sartre’s phenomenology and drama: The case of Dirty Hands
Authors: Duran Jane 
Published: August 2021

AbstractIn this paper, a number of lines of argument buttress and support the contention that Dirty Hands is a comparatively undervalued part of the Sartrean oeuvre. Using commentary from Bell and Pellauer, and employing categories relevant also to the work of Beauvoir and Camus, the paper comes to the conclusion that Hugo, as the central character of the play, is an exemplary Sartrean protagonist, and that the play is worthy of more attention than it has received. An important part of the central assertion is that the play is as critical a part of the Sartrean dramatic canon as The Flies and No Exit.