bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional Reconstruction of Weak-lensing Mass Maps with a Sparsity Prior. I. Cluster Detection
Authors: Li Xiangchong , Yoshida Naoki , Oguri Masamune , Ikeda Shiro , Luo Wentao 
Published: July 2021

Abstract
We propose a novel method to reconstruct high-resolution three-dimensional mass maps using data from photometric weak-lensing surveys. We apply an adaptive LASSO algorithm to perform a sparsity-based reconstruction on the assumption that the underlying cosmic density field is represented by a sum of Navarro–Frenk–White halos. We generate realistic mock galaxy shear catalogs by considering the shear distortions from isolated halos for the configurations matched to the Subaru Hyper Suprime-Cam Survey with its photometric redshift estimates. We show that the adaptive method significantly reduces line-of-sight smearing that is caused by the correlation between the lensing kernels at different redshifts. Lensing clusters with lower mass limits of 1014.0 h−1
M
⊙, 1014.7 h−1
M
⊙, 1015.0 h−1
M
⊙ can be detected with 1.5σ confidence at the low (z < 0.3), median (0.3 ≤ z < 0.6), and high (0.6 ≤ z < 0.85) redshifts, respectively, with an average false detection rate of 0.022 deg−2. The estimated redshifts of the detected clusters are systematically lower than the true values by Δz ∼ 0.03 for halos at z ≤ 0.4, but the relative redshift bias is below 0.5% for clusters at 0.4 < z ≤ 0.85. The standard deviation of the redshift estimation is 0.092. Our method enables direct three-dimensional cluster detection with accurate redshift estimates.
Characteristics of Interplanetary Discontinuities in the Inner Heliosphere Revealed by Parker Solar Probe
Authors: Liu Y. Y. , Fu H. S. , Cao J. B. , Liu C. M. , Wang Z. , Guo Z. Z. , Xu Y. , Bale S. D. , Kasper J. C. 
Published: July 2021

Abstract
We present a statistical analysis for the characteristics and spatial evolution of the interplanetary discontinuities (IDs) in the solar wind, from 0.13–0.9 au, by using the Parker Solar Probe measurements on Orbits 4 and 5. We collected 3948 IDs, including 2511 rotational discontinuities (RDs) and 557 tangential discontinuities (TDs), with the remnant unidentified. The statistical results show that (1) the ID occurrence rate decreases from 200 events per day at 0.13 au to 1 event per day at 0.9 au, following a spatial scaling of r
−2.00, (2) the RD to TD ratio decreases quickly with the heliocentric distance, from 8 at r < 0.3 au to 1 at r > 0.4 au, (3) the magnetic field tends to rotate across the IDs, 45° for TDs and 30° for RDs, in the pristine solar wind within 0.3 au, (4) a special subgroup of RDs exists within 0.3 au, characterized by small field rotation angles and parallel or antiparallel propagations to the background magnetic fields, (5) the TD thicknesses normalized by local ion inertial lengths (d

i
) show no clear spatial scaling and generally range from 5–35 d
i and the normalized RD thicknesses follow an r
−1.09 spatial scaling, and (6) the outward (antisunward) propagating RDs predominate in all RDs, with the propagation speeds in the plasma rest frame proportional to r
−1.03. This work could improve our understanding of the ID characteristics and evolution and shed light on the study of the turbulent environment in the pristine solar wind.
Alfvénicity-related Long Recovery Phases of Geomagnetic Storms: A Space Weather Perspective
Authors: Telloni Daniele , D’Amicis Raffaella , Bruno Roberto , Perrone Denise , Sorriso-Valvo Luca , Raghav Anil N. , Choraghe Komal 
Published: July 2021

Abstract
This paper reports, for the first time on a statistical basis, on the key role played by the Alfvénic fluctuations in modulating the recovery phase of the geomagnetic storms, slowing down the restoration of the magnetosphere toward its pre-storm equilibrium state. Using interplanetary and geomagnetic measurements collected over more than one solar cycle, a high correlation between the durations of Alfvénic streams and concurrent recovery phases is found, pointing to a clear coupling between Alfvénic turbulence and magnetospheric ring current dynamics. By exploiting current solar wind models, these observations also provide space weather opportunities of predicting the total duration of any geomagnetic storm induced by any solar driver provided that it is followed by an Alfvénic stream, a crucial piece of information for ground technologies and infrastructures that are affected by time-integrated effects throughout the duration of the storm.
An Observational Signature of Sub-equipartition Magnetic Fields in the Spectra of Black Hole Binaries
Authors: Wallace John , Pe’er Asaf 
Published: July 2021

Abstract
A common assumption used in the study of accretion disks is that the magnetic energy density and the kinetic energy density should be in equipartition. This assumption relies on the faster growth rate of the magnetic field strength against the kinetic energy of the particles in the flow, for decreasing radius, combined with a dissipation mechanism that tends toward equipartition. In this paper, we examine this assumption by modeling the radio, millimeter, and optical spectra of several black hole binaries in their quiescent state. We use a standard two-component disk model, consisting of an inner geometrically thick and optically thin disk, emitting thermal synchrotron radiation, along with an outer, thin disk, which radiates as a multicolor blackbody. We find that at the low accretion rates typical of the quiescent state, the spectral shape is qualitatively reproduced using magnetic fields that are between 0.1% and 1% of the equipartition value, considerably smaller than previously thought. We discuss our findings in view of (1) the launching of jets in these objects, which is commonly believed to rely on the presence of a strong magnetic field in the central region of the disk, and (2) the role of magnetic dissipation in the structure of the inflow.
A Magnetic Disk-outflow Model for Changing Look Active Galactic Nuclei
Authors: Feng Junjie , Cao Xinwu , Li Jia-wen , Gu Wei-Min 
Published: July 2021

Abstract
The timescales of the variabilities in changing look (CL) active galactic nuclei (AGNs) are usually on the order of years to tens of years (some of them are even shorter than one year), which is much shorter than the viscous timescale of a standard thin accretion disk. This implies that the variabilities of CL AGNs cannot be reproduced by varying the mass accretion rate of the thin disk. In this work, we employ a magnetic accretion disk-outflow model to calculate the inflow time of the disk predominantly driven by magnetic outflows. In this model, most angular momentum of the gas in the disk is carried away by the outflows, and therefore its radial velocity can be substantially higher than that of a conventional viscous disk. Our calculations show that the inflow time of such a disk with outflows can be around several years to tens of years. The calculated spectra of the disk with outflows can fit the observed spectra of a CL AGN Mrk 1018 quite well both in the low and high states. The derived inflow time of such a disk with outflows is around 5 yr in the high state, while it becomes ∼20 yr in the low state, which is roughly consistent with the observations of the variabilities in Mrk 1018.
Deuterated Polycyclic Aromatic Hydrocarbons in the Interstellar Medium: The C–D Band Strengths of Multideuterated Species
Authors: Yang X. J. , Li Aigen , He C. Y. , Glaser R. 
Published: July 2021

Abstract
Observationally, the interstellar gas-phase abundance of deuterium (D) is considerably depleted and the missing D atoms are often postulated to have been locked up into carbonaceous solids and polycyclic aromatic hydrocarbon (PAH) molecules. An accurate knowledge of the fractional amount of D (relative to H) tied up in carbon dust and PAHs has important cosmological implications since D originated exclusively from the Big Bang and the present-day D abundance, after accounting for the astration it has experienced during Galactic evolution, provides essential clues to the primordial nucleosynthesis and the cosmological parameters. To quantitatively explore the extent to which PAHs could possibly accommodate the observed D depletion, we have previously quantum-chemically computed the infrared vibrational spectra of monodeuterated PAHs and derived the mean intrinsic band strengths of the 3.3 μm C–H stretch (A
3.3) and the 4.4 μm C–D stretch (A
4.4). Here we extend our previous work to multideuterated PAH species of different deuterations, sizes, and structures. We find that both the intrinsic band strengths A
3.3 and A
4.4 (on a per-unit-bond basis) and their ratios A
4.4/A
3.3 not only show little variation among PAHs of different deuterations, sizes, and structures, they are also closely similar to that of monodeuterated PAHs. Therefore, a PAH deuteration level (i.e., the fraction of peripheral atoms attached to C atoms in the form of D) of ∼2.4% previously estimated from the observed 4.4 to 3.3 μm band ratio based on the A
4.4/A
3.3 ratio of monodeuterated PAHs is robust.
The Augmentation Effect of N-Acetyl Cysteine Antioxidant on Superoxide Dismutase Levels in Schizophrenic Patients Treated with Risperidone
Authors: Camellia Vita , Khairunnisa Khairunnisa , Ichwan Muhammad , Husada Muhammad Surya , Effendy Elmeida , Rusdiana Rusdiana , Hendriaty Deasy 
Published: July 2021

Background: Schizophrenia affects approximately 1% of the population and in Indonesia the prevalence is about 400.000 people or as many as 1.7 per 10000 individuals of the population. Schizophrenia is characterized by positive symptoms, negative symptoms and also cognitive, aggressive, and affective symptoms, where negative symptoms reflect loss of function.
One important factor that plays a role in the pathophysiology of schizophrenia is the excessive production of free radical substances and the failure of the anti-oxidant defense process.
The aim of this study is to see how levels of superoxide dismutase change after N-acetylcystein augmentation in schizophrenic patients treated with risperidone. This study is a pre-post experimental test design, where schizophrenic patients meet inclusion and exclusion criteria. At baseline, and after 8 weeks of N-acetyl cysteine administration, patients were assessed at each of the time points using PANSS, and SOD was measured in blood at both time points.
The average negative PANSS score in the Risperidone + NAC baseline group was 29.93 (±1.83); in the Risperidone group was 29.83 (±1.19) (p = 0.87). The average negative PANSS score at the end of week 8 was statistically significantly different (p = 0.001) in the Risperidone + NAC group (17.40 ±1.84) and in the Riseridone group (21.00±0.74). The average baseline SOD levels in the Risperidone + NAC group were 63.57 (±22.44), and in the Risperidone group was 85.79 (±101.05). SOD levels at week 8 in the Risperidone + NAC group were 71.72 (±31.20) and in the Risperidone group 128.27 (±117.67). ∆ SOD in the Risperidone + NAC group was 8.15 (19.54) and ∆ SOD in the Risperidone group was 42.48± (54.30). p value of 0.028Research data shows that NAC augmentation can improve the negative symptoms of schizophrenia through reducing SOD levels in the blood.
Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells
Authors: Man Stephen , Redman James E , Cross Deborah L , Cole David K , Can Ilona , Davies Bethan , Hashimdeen Shaikh Shimaz , Reid Reiss , Llewellyn-Lacey Sian , Miners Kelly L , Ladell Kristin , Lissina Anya , Brown Paul E , Wooldridge Linda , Price David A , Rizkallah Pierre J 
Published: July 2021

Abstract
The human CD8+ T cell clone 6C5 has previously been shown to recognize the tert-butyl-modified Bax161–170 peptide LLSY(3-tBu)FGTPT presented by HLA-A*02:01. This nonnatural epitope was likely created as a by-product of fluorenylmethoxycarbonyl protecting group peptide synthesis and bound poorly to HLA-A*02:01. In this study, we used a systematic approach to identify and characterize natural ligands for the 6C5 TCR. Functional analyses revealed that 6C5 T cells only recognized the LLSYFGTPT peptide when tBu was added to the tyrosine residue and did not recognize the LLSYFGTPT peptide modified with larger (di-tBu) or smaller chemical groups (Me). Combinatorial peptide library screening further showed that 6C5 T cells recognized a series of self-derived peptides with dissimilar amino acid sequences to LLSY(3-tBu)FGTPT. Structural studies of LLSY(3-tBu)FGTPT and two other activating nonamers (IIGWMWIPV and LLGWVFAQV) in complex with HLA-A*02:01 demonstrated similar overall peptide conformations and highlighted the importance of the position (P) 4 residue for T cell recognition, particularly the capacity of the bulky amino acid tryptophan to substitute for the tBu-modified tyrosine residue in conjunction with other changes at P5 and P6. Collectively, these results indicated that chemical modifications directly altered the immunogenicity of a synthetic peptide via molecular mimicry, leading to the inadvertent activation of a T cell clone with unexpected and potentially autoreactive specificities.
Tyr192 Regulates Lymphocyte-Specific Tyrosine Kinase Activity in T Cells
Authors: Borowicz Paweł , Sundvold Vibeke , Chan Hanna , Abrahamsen Greger , Kjelstrup Hanna , Nyman Tuula A , Spurkland Anne 
Published: July 2021

Abstract
TCR signaling critically depends on the tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase). Two phosphotyrosines, the activating pTyr394 and the inhibitory pTyr505, control Lck activity. Recently, pTyr192 in the Lck SH2 domain emerged as a third regulator. How pTyr192 may affect Lck function remains unclear. In this study, we explored the role of Lck Tyr192 using CRISPR/Cas9-targeted knock-in mutations in the human Jurkat T cell line. Our data reveal that both Lck pTyr394 and pTyr505 are controlled by Lck Tyr192. Lck with a nonphosphorylated SH2 domain (Lck Phe192) displayed hyperactivity, possibly by promoting Lck Tyr394 transphosphorylation. Lck Glu192 mimicking stable Lck pTyr192 was inhibited by Tyr505 hyperphosphorylation. To overcome this effect, we further mutated Tyr505. The resulting Lck Glu192/Phe505 displayed strongly increased amounts of pTyr394 both in resting and activated T cells. Our results suggest that a fundamental role of Lck pTyr192 may be to protect Lck pTyr394 and/or pTyr505 to maintain a pool of already active Lck in resting T cells. This provides an additional mechanism for fine-tuning of Lck as well as T cell activity.
Knowledge, attitude, and practice toward glaucoma and its management among adult Saudi patients
Authors: Al Rashed Waleed A. , Bin Shihah Abdulelah S. , Alhomoud Abdulrahman S. , Alharbi Muteb M. , Shadid Asem M. , Alghamdi Mushref A. , Alfaris Alanoud , Alrashed Ahmad W. , Osman Essam A. , Khandekar Rajiv 
Published: July 2021

PURPOSE:
To present the level of knowledge, attitude, and practice (KAP) for glaucoma management and their determinants among adult Saudi patients.

METHODS:
The study was conducted between January and June 2017. Glaucoma patients from the ophthalmology clinic were interviewed. Demographics and disease-related information were noted. The questionnaire included four K questions, seven A questions, and six P squestions. The correct response of questions were summed for K, A, and P, and the percentile was calculated. K and P scores were graded as excellent (more than >75%), good (51%–75%), poor (26%–50%), and very poor (≤25%). If A score was >50%, it was termed as positive.

RESULTS:
We interviewed 263 adult glaucoma patients. Their mean age was 61.6 ± 14.2 years. The excellent grade of knowledge about glaucoma and its management was 63 (24% [95% confidence interval (CI) 18.8–29.1]). Poor grade of knowledge was 95 (36.1% [95% CI 30.3–41.9]). The attitude toward glaucoma and its management was positive in 89 (33.8% [95% CI 28.1–39.6]). The practice to manage glaucoma was of excellent grade in 10 (3.8% [95% CI 1.5-6.1]). The overall excellent grade of KAP glaucoma patients was 17.9% (13.2–22.5). Good practice for glaucoma management was associated with a history of glaucoma surgery (P < 0.001), longer duration of glaucoma (P = 0.02), and young age (P = 0.004).

CONCLUSIONS:
Low KAP about glaucoma disease and medication among Saudi glaucoma patients is a matter of concern. Strategies are needed to improve the KAP of glaucoma patients.
Patient preference and pain-reported outcomes for topical versus subtenon anesthetic for cataract surgery
Authors: Ryan Adam , Sadiq Omair , Tolley Suzanne , Wijetilleka Sidath , Williams Gwyn S. 
Published: July 2021

PURPOSE:
Cataract extraction and lens implantation is the most common surgical procedure performed worldwide, with surgeons opting for either a topical or a subtenon anesthetic in majority of cases. While complication rates and pain scores have been previously examined in a bid to determine which modality was better, patients who have had both eyes operated upon under different techniques have never previously been asked which method they prefer. We undertook this study to fill in this crucial gap in our knowledge.

METHODS:
This is a retrospective study of patients who have undergone bilateral cataract surgery with one eye operated on with topical anesthesia and the other eye with subtenon anesthesia. Patients were identified who had had surgery undertaken in the previous 6 months at Singleton Hospital, Swansea, where both eyes had been operated upon using different anesthetic techniques. Telephone interviews with these patients were performed and their pain scores recorded on a scale from 0 (no pain) to 10 (severe pain) for both eyes, with the patients then being asked which the method of anesthetic they preferred. Statistical analysis of pain scores was compared using Wilcoxon rank-sum testing.

RESULTS:
One hundred and fifty-two patients in total were identified. One hundred and forty-one of the applicable patients participated in the study. Of these, 78 patients received topical anesthesia for their first operation and 63 had subtenon block for their first operation. The mean pain scores reported for surgery with topical anesthesia and subtenon block were 2.30 and 1.38, respectively. The pain data were analyzed using a Wilcoxon signed-rank test, returning a z-score of 4.038. This result therefore suggests that patients experience statistically significantly less pain from cataract surgery when given a subtenon block. Patients expressed a preference for subtenon anesthesia, with 70% preferring subtenon block, 23% preferring topical anesthesia, and 7% having no preference.

CONCLUSIONS:
Patients report less pain with subtenon anesthesia compared with topical anesthesia in cataract surgery, where both eyes were operated upon with different anesthetic techniques. This is the first study in which patients who have had both anesthetic techniques performed independently for cataract surgery have had their pain scores reported and statistically analyzed.
Patient Awareness of Oral Health and Periodontal Disease as a Potential Risk Factor of Breast Cancer
Authors: Fouad Ahmed , Patel Fatimah , Al-Thagafi Maha , Yahya Mawed , Roshdy Mohamed 
Published: July 2021

Introduction:
Breast cancer (BC) is a public health problem and the most frequent malignancy among women. Oral health is important and directly related to the overall general health of the body; it is dependent and related to oral health knowledge and oral hygiene behavior. Several studies have associated links between BC and periodontal disease (PD). The aim of the study was to assess oral health and periodontal disease awareness and potential risk factors of BC in a sample of Jeddah residents.

Materials and Methods:
A cross-sectional study was conducted on 106 adults with a self-answered questionnaire in the framework of a community service initiative sponsored by the Ministry of Health on the occasion of the world BC month, where the college students participated in.

Results:
In our study population, 68.68% of participants expressed proper oral hygiene awareness, while merely 42.72% identified the correct risk factors of BC. Only 12.3% had awareness of PD as a potential risk factor of BC, and their awareness was measured against their oral hygiene and periodontal health awareness, where 92.3% acknowledged the negative effect of oral hygiene neglect on the overall body health, 76.9% heard of dental plaque biofilm, and only 23.1% identified it as the causative of PD. Finally, 61.5% cleaned their teeth twice a day in accordance with the recommendations of the Saudi Dental Society.

Conclusion:
There is an urgent need for comprehensive educational programs to promote correct oral hygiene practice and educate on its positive impact on the overall body health. The knowledge and awareness on BC and PD can still rise by community services and awareness campaigns throughout the city of Jeddah.
Reducing Intraventricular Hemorrhage in Preterm Babies Less Than 30 Weeks of Gestation in Neonatal Intensive Care Unit, Level III
Authors: El Amouri Souher , Bystricka Alica , Paulose Amrtha , Qadir Maqbool , Khan Junaid Muhib 
Published: July 2021

Intraventricular hemorrhage (IVH) is bleeding into the brain's ventricular system or around the ventricles. The etiology of IVH is multifactorial and is primarily attributed to the fragility of the germinal matrix vasculature and disturbance of cerebral blood flow. IVH is rarely present at birth. Infants born before the 30th week of gestation and weighting <1500 g at birth are at risk for this type of bleeding. The smaller and more premature, unstable infants are at the highest risk for IVH. It occurs more often in the first several days of life. This situation creates immense burden and dilemma for health-care providers mainly when challenged by family choice to withdraw support or do-not-resuscitate incompatible with country law.

Purpose:
To reduce the overall incidence of IVH to <10% among preterm babies born <30 weeks of gestation using a neuro bundle of care.

Methodology:
A quality descriptive improved project was conducted in one government sector hospital in Abu Dhabi, Level III neonatal intensive care unit. It was a retrospective study where the data were collected from 2018 to 2019. A multidisciplinary team was formed to implement the neurobundle. Descriptive statistics were used to describe the demographic and clinical finding of the project.

Results:
Five out of 32 infants and 1 out of 17 infants developed IVH (Grade IV), respectively, in 2018 and 2019.

Conclusion:
The IVH rate in premature neonates has reduced drastically from 19% (preintervention) to 6% (postintervention) due to implementation IVH bundle and staff compliance.