bluuebunny/crossref_metadata_2025_split huggingface dataset:
G-Protein coupled Purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodelling in microglia
Authors: Chidambaram Hariharakrishnan , Das Rashmi , Chinnathambi Subashchandrabose 
Published: May 2021

ABSTRACTIn Alzheimer’s disease, the microtubule-associated protein, Tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. Microglial cells are the resident brain macrophage cells that are involved in constant surveillance and are activated by the extracellular deposits. Purinergic receptors are involved in chemotactic migration of microglial cells towards the site of inflammation. In our recent study, we found that microglial P2Y12 receptor has been involved in phagocytosis of full-length Tau species such as monomers, oligomers and aggregates by actin-driven chemotaxis. In this study, we have showed the interaction of repeat-domain of Tau (TauRD) with microglial P2Y12 receptor and analysed the corresponding residues for interaction by variousin-silicoapproaches. In cellular studies, TauRDwas found to interact with microglial P2Y12R and induces its cellular expression as confirmed by coimmunoprecipitation and western blot analysis respectively. Similarly, immunofluorescence microscopic studies emphasized that TauRDwere phagocytosed by microglial P2Y12Rviathe membrane-associated actin remodelling as filopodia extension. Furthermore, the P2Yl2R-mediated TauRDinternalization has activated the microglia with an increase in the Iba1 level and TauRDbecome accumulated at peri-nuclear region as localized with Iba1. Altogether, microglial P2Y12R interacts with TauRDand mediates directed migration and activation for its internalization.
How shareholder resources impact on the allocation of control power: example of China Vanke
Authors: Gao Li , Song Jinnan , Liang Jiajuan , Guo Jianxiao 
Published: May 2021

Purpose
This paper aims to explore the influence of founder shareholders’ resources on the allocation of control rights from the perspective of incomplete contract theory and resource-based theory.

Design/methodology/approach
This paper analyzes newspaper materials with NVivo11on a case of battle for corporate control in Chinese top-listed company-Vanke Group.

Findings
The research shows that human capital is the key resource and the holding proportion of financial resources directly affects the allocation of control rights. At the same time, social capital is unstable and easily broken. At last, institutional environment also affects the degree between the relationship of founder shareholders’ resources and the allocation of control rights. The influence of founder-shareholder resources on the allocation of control rights follows the path of “crisis – founder-shareholder’s resources – founder’s ability - allocation of control rights.”

Research limitations/implications
This study only selects the financial capital, human capital and social capital of Shi Wang, the founder of Vanke, as the analysis object. The study can expand the types of founder shareholder resources to verify and enrich the conclusions.

Originality/value
The current theoretical research in the literature focuses on the necessity of equity and shareholder’s resources versus the control rights. Some key factors and mechanism on the relationship have not been fully clarified. The results of this paper not only extend the combination research of social network and corporate governance, but also provide enterprise founders with references for making reasonable decisions during control battle.
“My only solution is to work later and sleep less”: exploring the perspectives of parenting in academia in Ontario, Canada
Authors: Smith-Carrier Tracy A. , Benbow Sarah , Lawlor Andrea , O'Reilly Andrea 
Published: May 2021

PurposeThe purpose of this study is to explore the experiences of parents who have full professorial positions (in faculties of engineering and nursing) in universities in Ontario, Canada, with a particular focus on the ways in which gender shapes professors' parenting experiences.Design/methodology/approachWe employ a case study methodology involving quantitative and qualitative data collected from a survey emailed to full professors in Ontario.FindingsData from the study reveal that numerous strategies, resources (e.g. informal social support networks, supportive partners) and institutional supports (i.e. pausing the tenure clock after child birth) are required to assist academics to meet the extensive demands of their positions, while they perform caregiving responsibilities for their children.Research limitations/implicationsThe protected ground of family status is inconsistently applied in Canadian human rights policy, considerably reducing its transformative potential. Yet, while family status gains greater recognition in rights-based practice, we argue that it be added to forthcoming institutional equity, diversity and inclusion (EDI) action plans across post-secondary institutions to better ensure equity for mothers who shoulder significant paid and unpaid work responsibilities.Originality/valueWhile there is literature on parenting in academia, family status is rarely featured as an intersection of interest in EDI research. This article aims to fill this gap.
Explaining different types of undeclared work: lessons from a 2019 Eurobarometer survey
Authors: Williams Colin , Oz-Yalaman Gamze 
Published: May 2021

PurposeUntil now, most scholars have used one of four competing theories to explain undeclared work. Political economy theories explain undeclared work as resulting from the exclusion of workers from formal work and welfare, neo-liberal theories explain such work as a voluntarily chosen rational economic decision and neo-institutionalist and post-structuralist theories explain those engaging as social actors who disagree with the formal rules or seek to help others out respectively. Recognising that each theory focuses upon different employment relationships, this paper evaluates the proposition that these different theories are more explanations of different types of undeclared work.Design/methodology/approachTo evaluate this, data reported is collected in 2019 across 28 European countries (the 27 member states of the European Union and the United Kingdom) in special Eurobarometer survey 92.1 involving 27,565 interviews.FindingsOf the 3.6% of citizens participating in undeclared work, 10% engage in undeclared waged employment, 42% in undeclared self-employment and 48% in undeclared paid favours. Reporting their rationales, 7% state purely political economy exclusion-driven reasons, 19% solely neo-liberal rational economic actor reasons, 20% purely social actor reasons and 54% mixed motives. A logistic regression analysis finds those engaging in undeclared waged employment significantly more likely to state purely exclusion-driven rationales, those engaging in undeclared self-employment significantly more likely to state neo-liberal rational economic actor and neo-institutionalist social actor rationales and those engaging in undeclared paid favours post-structuralist social actor motives.Practical implicationsThis finding suggests that the policy initiatives required to tackle undeclared work will vary according to the type of undeclared work addressed. These are outlined.Originality/valueEvidence is provided that a different weighting needs to be given to different theories when explaining each type of undeclared work.
Validating an information privacy governance questionnaire to measure the perception of employees
Authors: Swartz Paulus , Da Veiga Adele , Martins Nico 
Published: May 2021

PurposeThis study aims to conduct a survey in a bank to measure the perception of employees towards the effective governance of information privacy and at the same time validating the information privacy governance questionnaire (IPGQ) used in this study.Design/methodology/approachA quantitative research approach was followed using an online survey questionnaire to collect data in a bank in South Africa.FindingsThe survey results showed that employees perceived the governance of privacy in the organisation in a positive way. Three significant differences were identified, namely, Generation-Y being significantly more positive than Generation-X regarding privacy control assessment. Also, that the contractor/vendor group was significantly more positive than permanent employees regarding organisational commitment and privacy control assessment. Exploratory factor analysis was used to validate the IPGQ and four factors were identified: privacy control assessment, personal information awareness assessment, privacy governance reporting and organisational commitment towards privacy. Cronbach’s alpha was used to establish the internal reliability of the factors and indicated good internal consistency.Research limitations/implicationsOne of the potential empirical research limitations for this study is that the study was conducted in a single organisation; therefore, when generalising the results, caution must be taken.Practical implicationsOrganisations, academics and the industry may find the questionnaire useful to determine employee perception towards privacy governance and to identify recommendations that could be used to improve their privacy policies, privacy programme controls and organisational commitment towards privacy. In this study, it was identified that for Generation-X employees to be more accepting towards the privacy controls, the organisation needs to implement focussed awareness training for them. To ensure permanent employees’ commitment and accountability, internal audits, monitoring and risk assessment measures need to be implemented. These can be directed through the outcomes of the survey.Originality/valueThe IPGQ can aid organisations in determining if they are governing privacy effectively, and thus assist them in meeting the accountability condition of data protection regulation.
Strategic supplier management in nascent firms: an examination of how nascent firms improve customer attractiveness to obtain strategic supplier collaboration
Authors: Jenkins Matthew , Holcomb Mary 
Published: May 2021

PurposeThe purpose of this paper is to empirically investigate the activities that nascent firms undertake to improve customer attractiveness and gain collaborative commitment from strategic suppliers.Design/methodology/approachData from a grounded theory study consisting of 26 participants from 15 firms and a review of extant literature were used to develop a theoretical model that explains how a nascent firm increases its customer attractiveness to elicit commitment and collaboration from strategic suppliers.FindingsThe authors find that social capital, born of close social ties and social history, enhances the effectiveness of a nascent firm's relationship-building practices. This counteracts a supplier's collaborative risk and consequently increases the nascent firm's customer attractiveness, thus enabling it to obtain strategic supplier collaborative commitment.Practical implicationsThis research helps managers by providing direction on what practices nascent firms pursue to gain strategic supplier resources and collaboration. Given the reality of resource constraints in nascent firms, it is suggested that this insight is essential to obtaining crucial external resources needed to survive and grow.Originality/valueExtant research on buyer–supplier collaboration is mostly confined to the context of mature firms and does not account for the unique inter-organizational relational challenges faced by nascent firms. This research uncovers the idiosyncrasies of supplier management in nascent firms, and elucidates on the actions that nascent firm managers take to gain supplier collaborative commitment.
Understanding the relationship between university characteristics and prestige
Authors: Topaler Başak , Ayvaz-Çavdaroğlu Nur 
Published: May 2021

Purpose
Being a prestigious institution depends on gaining respect in the eyes of various stakeholders with diverse expectations. Existing research is silent on how university characteristics affect judgments of prestige and, therefore, presents an incomplete picture of prestige dynamics in higher education. This paper aims to fill this gap in the literature by empirically examining the stakeholders’ evaluation of university characteristics in terms of prestige value.

Design/methodology/approach
The entire population of universities (public and private) in Turkish higher education constitutes the sample of the study. The analytic hierarchy process technique is applied to ascertain how stakeholders prioritize university characteristics in terms of prestige value, and regression analysis is used to determine the effects of these characteristics on university selectivity.

Findings
The findings suggest a novel conceptual model of university prestige, which establishes its multilayered and fragmented nature. Accordingly, universities may be subject to multiple prestige hierarchies based on universal or context-specific criteria, in the eyes of various stakeholders, and based on different markers of success.

Research limitations/implications
The empirical analyses are limited to the stakeholder groups that are key to university outcomes in Turkish higher education, and to selectivity in admissions as the only visible marker of success in this context.

Originality/value
The study enhances existing literature that posits that universities are subject to a single prestige hierarchy based on common metrics of performance. It illustrates the uneven landscape in which university prestige evolves by developing a wider and deeper focus on university characteristics.
Examining the effect of training and employee creativity on organizational innovation: a moderated mediation analysis
Authors: Chaubey Akriti , Sahoo Chandan Kumar , Das Kishore Chandra 
Published: May 2021

Purpose
The purpose of this study to understand the effects of training and creativity on organizational innovation under the moderating influence of the organizational climate.

Design/methodology/approach
The theoretical model is grounded in the contingent resource-based view. To test the research hypotheses, this paper has gathered the cross-sectional data using a single informant pre-tested questionnaire. The data were collected from respondents working in Indian automotive manufacturing organizations. The data were further tested for the normality criteria followed by hypotheses testing using co-variance-based structural equation modelling Statistical Package for Social Sciences (SPSS), 2010.

Findings
The relationship between training and organizational innovation was leveraged by employee creativity, which acts as a mediator between the two. Moreover, the organizational climate augments the mediation process by coherently creating a positive moderating influence.

Practical implications
This study provides prospective insights to management leaders and practitioners by establishing how training can bring about positive change in the innovative front of the organization. It also offers keys to the organizations for an active engagement of the employees through a supporting climate conducive for harnessing of individual creativity and innovative potential.

Originality/value
This is the first endeavour made to examine the moderated mediation influence of organizational climate on training and employee creativity, by studying the mediating effect of employee creativity between training and organizational innovation.
The effect of HRIS implementation success on job involvement, job satisfaction and work engagement in SMEs
Authors: Maamari Bassem E. , Osta Alfred 
Published: May 2021

PurposeThe purpose of the study is to highlight the effect of human resources information systems (HRISs) implementation success on the job involvement, job satisfaction and work engagement of the employees in small and medium enterprises (SMEs).Design/methodology/approachFollowing an investigative study, a quantitative research is done with a positivist approach. A sample of 1,082 responses from 163 SMEs in different economic sectors is analyzed using statistical package for social sciences and structural equation modelling.FindingsThe results show that HRIS successful implementation explains the variation in job involvement and work engagement to a limited extent while it does highly affect employees’ job satisfaction. Moreover, the correlation between job involvement and both HRIS implementation success and job satisfaction is negative.Research limitations/implicationsThe researchers were not able to conduct intersector analysis for differences among economic sectors. Existing gender differences in job involvement, work engagement and job satisfaction are hinted to and need further analysis.Practical implicationsThe HRIS users with higher educational background tend to display a more open approach toward using the system and seeing the system’s implementation succeed. Tenured managers display low enthusiasm toward HRIS success, although being highly involved and engaged in the SME’s life. This provides for not only a steady work-flow but also fosters resistance to change. The successful implementation of the HRIS is a new dimension in the hands of managers at work, facilitating their supervisor work routines and affecting employees’ satisfaction, involvement and engagement.Social implicationsThe HRIS success allows more flexibility at the supervisor level of daily work, opening a window toward flexible working hours and indirect supervision. It allows users some freedom and flexibility and the application of their own ethical beliefs when self-reporting.Originality/valueAlthough most research looks at corporations and the factors leading to HRIS implementation success, this study goes beyond the implementation to dwell into Small and Medium Enterprises (SMEs), looking at HRIS after its implementation success, as a potential tool for motivating, involving and engaging employees.
Determinants and consequences of brand credibility: a case study in the pharmaceutical industry
Authors: Maia Bairrada Cristela , Fontes da Costa João , Santos Rui Manuel , Coelho Arnaldo 
Published: May 2021

Purpose
The purpose of this paper is to present a conceptual model that intends to identify the determinants and consequences of brand credibility, specifically in the pharmaceutical industry.

Design/methodology/approach
The hypotheses developed according to the proposed model were tested through an online questionnaire and answered by 225 individuals from Portugal.

Findings
The results show that the credibility of brand communication, perceived quality and brand familiarity are the key components that contribute most to the creation of a credible brand. Regarding consequences, this study confirms that, in the face of a credible brand, consumers are more willing to repeat the purchase, to pay more for it and to promote their opinion among other consumers.

Originality/value
This research innovates by presenting, for the first time, a conceptual model of brand credibility specific to the non-prescription medicines market, thus contributing to a better understanding of this issue by companies and brand managers of the pharmaceutical industry.
Work from home: Indonesian employees' mental well-being and productivity during the COVID-19 pandemic
Authors: Sutarto Auditya Purwandini , Wardaningsih Shanti , Putri Wika Harisa 
Published: May 2021

PurposeThe purpose of this study is to explore to what extent employees' mental well-being affects their productivity while working from home (WFH) during the COVID-19 crisis and whether mental well-being and productivity differ across some socio-demographic factors.Design/methodology/approachA cross-sectional study with online questionnaires was designed with 472 valid responses in Indonesia. Depression, Anxiety and Stress Scale (DASS-21) and Individual Work Performance Questionnaire (IWPQ) were administered. Non-parametric tests and structural equation modeling were employed to analyze the data.FindingsThe prevalence of depression was 18.4%, anxiety 46.4% and stress 13.1%, with relatively good productivity. Gender, age, education level, job experiences, marital status, number of children and nature of the organization were associated with the employees' psychological health but not with their productivity, while the workspace availability influenced both outcomes. The study path model showed the negative correlation between WFH employees' psychological well-being and productivity.Research limitations/implicationsThis study may contribute to the implication of current mandatory WFH on mental well-being and productivity. Further studies need to address the representativeness and generalizability issues as well as incorporating potential stressors.Practical implicationsOrganizations may adopt WFH as a future working arrangement and identify the individual and occupational characteristics that provide the most impacts on productivity. It is also necessary for them to develop proper strategies to mitigate the psychological risks and overcome the WFH challenges.Originality/valueThere is still a lack of studies investigating the relationship between simultaneous effects of WFH on psychological well-being and productivity, and how they affect some socio-demographic variables in the context of COVID-19.
A robust fuzzy optimization approach for reverse logistics network design with buyback offers
Authors: Amirdadi Masoud , Dehghanian Farzad 
Published: May 2021

PurposeIn this paper, the authors aim to investigate the relationship between buyback policy and the potential number of used products that could be collected by developing a robust fuzzy reverse logistics network.Design/methodology/approachIn this approach, the authors seek to determine the amount of buyback based on the condition of used products at the time of return. In this process, the authors also take into account that apart from the condition of used products, other factors exist that the actual return rate could be dependent on them. This matter propelled us to make a novel distinction between the probability of return estimated from appropriate buybacks offered to consumers, and the actual return rate of used products using fuzzy mathematical methods. Besides that, a compatible robust fuzzy optimization method has been implemented on the model to deal with uncertain properties of it and simultaneously fortifying its responses against any possible effect of return rate fluctuation.FindingsTo analyze and evaluate the model performance, the authors decided to apply a series of exhaustive randomly generated experiments onto it. Also, the authors introduced a Lagrangian relaxation solution methodology to facilitate and improve the solving process of the model. Then, the evaluation of the results enabled us to demonstrate the model validity, and underscore its utility to deal with problems with more sophisticated used product collection process that practitioners tend to encounter in the real-world circumstances.Originality/valueThis study suggests a novel way to design the return rate of used products in a reverse logistics network with buyback offers through a complete set of factors affecting it. Furthermore, the procedure of developing the model encompasses several important aspects that significantly decrease its complexity and improve its applicability.