bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Hypoxia on Growth and Differentiation of Human Adipose Derived Stem Cells Grown on Silk Fibroin Scaffold Induced by Platelet Rich Plasma
Authors: Barlian Anggraini , Tan Marselina Irasonia , Sarjana Ergha Widya , Vanawati Noviana 
Published: December 2021

Previous research has proven that 10% platelet-rich plasma (PRP) can enhance growth and differentiation of human adipose derived stem cells (hADSC) grown on silk fibroin scaffold into chondrocytes. A low oxygen concentration (hypoxia) condition is an important factor that potentially affects the ability of hADSC to grow and differentiate. The objective of this research was to analyze the difference in growth and differentiation capacity of hADSC grown on salt leached silk fibroin scaffold supplemented by 10% PRP under normoxic and hypoxic conditions. The growth capacity of the hADSC was determined by MTT assay and differentiation was tested using glycosaminoglycan (GAG) content analysis, while chondrocyte markers were visualized with the immunocytochemistry (ICC) method. This research observed hADSC proliferation under normoxic and hypoxic conditions for 21 days. Visualization of type 2 collagen showed that it was more abundant under hypoxia compared to normoxia. HIF-1α was only detected in the hADSC cultured in hypoxic conditions. In conclusion, culture under hypoxic conditions increases the capacity of hADSC to grow and differentiate into chondrocytes. This is the first study that has shown that hypoxia is able to enhance the proliferation and differentiation of hADSC grown on 3D salt leached silk fibroin scaffold supplemented by 10% PRP.
Association of Genetic Polymorphism of Tumor Necrosis Factor-α in the Development of Coronary Heart Disease in Elderly Patients
Authors: Mezhidov Bekkhan Saidmagomedovich , Bekova Khava Idrisovna , Edieva Aishat Alikovna , Madalova Khava Ismailovna , Malakhova Victoria Alekseevna , Uspaeva Zama Arbievna , Tachaeva Markha Sharipovna , Tsinaeva Amina Magomedovna , Maslova Alina Yurievna , Khodisov Shamil Vakhaevich 
Published: December 2021

The research project outlines a new look at the concept of "inflammaging" and the role of the subclinical inflammatory process in various age-associated pathology, in particular coronary heart disease. Particular attention is paid to the tumor necrosis factor-α -cytokine, which plays an important role in the pathogenesis of chronic inflammatory processes and in the aging process. The increased content of tumor necrosis factor-α leads to the emergence and accumulation of various diseases, disability and mortality of elderly and senile people.
Tumor necrosis factor-α influences various risk factors for cardiovascular pathology. This substance aggravates various breakdowns in metabolism, primarily causing insulin resistance. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (osteoporosis) and sarcopenia. Currently available data prove the important role of tumor necrosis factor-α in various age-associated pathologies.
Health Benefits, Utilization and Characterization of Rhododendron arboreum (Ericaceae)
Authors: Nitika . , Kumar Shubham , Singh Jasdeep 
Published: December 2021

Rhododendron arboreum is a small tree, mostly found in the mountain areas with pale pink or deep pink flowers, widely spread throughout the world. It is a member of the Ericaceae family, and it is well-known for its lovely flowers. R. arboreum species is distributed widely among the 80°N and 20°S latitudes and is designated as ‘State flower’ of Himachal Pradesh (India) and ‘National flower’ of Nepal. Due to its many inherent phytochemical properties, it is used as a treatment for various diseases such as bacterial infection, diarrhoea, and headache, infamy, and fungal infections. The people living in the mountainous area historically use the flowers of this plant to make variety of products viz. juice, squash, jelly, syrup, pickle, honey. R. arboreum have several important polyphenolic and bioactive compounds such as saponins, flavonoids and steroids. This review highlights Rhododendron's nutritional properties, potential properties and medicinal properties and various products developed, which boost livelihoods of the rural tribal community for sustainable growth and treatment of various diseases.
Micro‐/Nanorobots in Antimicrobial Applications: Recent Progress, Challenges, and Opportunities
Authors: Zhang Zifeng , Wang Lu , Chan Tony K. F. , Chen Zigui , Ip Margaret , Chan Paul K. S. , Sung Joseph J. Y. , Zhang Li 
Published: December 2021

AbstractThe evolution of drug‐resistant pathogenic bacteria remains one of the most urgent threats to public health worldwide. Even worse, the bacterial cells commonly form biofilms through aggregation and adhesion, preventing antibiotic penetration and resisting environmental stress. Moreover, biofilms tend to grow in some hard‐to‐reach regions, bringing difficulty for antibiotic delivery at the infected site. The drug‐resistant pathogenic bacteria and intractable biofilm give rise to chronic and recurrent infections, exacerbating the challenge in combating bacterial infections. Micro/nanorobots (MNRs) are capable of active cargo delivery, targeted treatment with high precision, and motion‐assisted mechanical force, which enable transport and enhance penetration of antibacterial agents into the targeted site, thus showing great promise in emerging as an attractive alternative to conventional antibacterial therapies. This review summarizes the recent advances in micro‐/nanorobots for antibacterial applications, with emphasis on those novel strategies for drug‐resistance bacterium and stubborn biofilm infections. Insights on the future development of MNRs with good functionality and biosafety offer promising approaches to address infections in the clinic setting.
Charge Carrier Lifetime Fluctuations and Performance Evaluation of Cu(In,Ga)Se2 Absorbers via Time‐Resolved‐Photoluminescence Microscopy
Authors: Ochoa Mario , Yang Shih‐Chi , Nishiwaki Shiro , Tiwari Ayodhya N. , Carron Romain 
Published: December 2021

AbstractThe open‐circuit voltage (VOC) is the main limitation to higher efficiencies of Cu(In,Ga)Se2 solar cells. One of the most critical parameters directly affecting VOC is the charge carrier lifetime. Therefore, it is essential to evaluate the extent to which inhomogeneities in material properties limit the carrier lifetime and how postdeposition treatments (PDTs) and growth conditions affect material properties. Time‐resolved photoluminescence (TRPL) microscopy is employed at conditions similar to one sun to study carrier lifetime fluctuations in Cu(In,Ga)Se2 with light (Na) and heavy (Rb) alkalis, different substrates, and grown at different temperatures. PDT lowers the amplitude of minority carrier lifetime fluctuations, especially for Rb‐treated samples. Upon PDT, the grains’ carrier lifetime increases, and the analysis suggests a reduction in grain boundary recombination. Furthermore, lifetime fluctuations have a small impact on device performance, whereas VOC calculated from TRPL (and continuous‐wave PL) agrees with device values within the limits of investigated PDT samples. Finally, up to about half a per cent external radiative efficiencies are experimentally determined from TRPL metrics, and internal radiative efficiencies are approximated. The findings demonstrate that the highest absorber material quality investigated is still limited by nonradiative recombination (grain or grain boundary) and is comparable to state‐of‐the‐art absorbers.
Graphite–Silicon Diffusion‐Dependent Electrode with Short Effective Diffusion Length for High‐Performance All‐Solid‐State Batteries
Authors: Kim Ju Young , Jung Seungwon , Kang Seok Hun , Park Joonam , Lee Myeong Ju , Jin Dahee , Shin Dong Ok , Lee Young‐Gi , Lee Yong Min 
Published: December 2021

AbstractElectrode design, which is closely related to electronic and ionic transport, is an essential factor that influences the performance of all‐solid‐state batteries. An in‐depth understanding of the movement of the charge carriers and its relationship to the electrode structure are urgently needed for the realization of advanced energy storage devices. Herein, a simple electrode configuration, which consists mostly of blended active materials of graphite and silicon, is presented to simultaneously satisfy the high power and high energy density of all‐solid‐state batteries. This electrode efficiently utilizes interdiffusion between the active material particles for charge/discharge. Mechanically compliant graphite accommodates the volume change of silicon and continuously provides abundant electrons to silicon, which enables a stable electrochemical reaction. Silicon with its higher volumetric capacity compared to graphite, shortens the effective diffusion pathway in the electrode. In particular, the use of the nanometer‐scale silicon leads to its uniform distribution throughout the electrode, which increases the contact area capable of interdiffusion between the graphite and silicon and reduces the diffusion in the agglomerated silicon with relatively low diffusivity. This morphology‐induced electrochemical change dramatically increases the achievable capacities at higher current densities (93.8% capacity retention (2.76 mAh cm−2) at 0.5 C‐rate (1.77 mA cm−2) relative to the capacity at 0.1 C‐rate).
Electrochemical Catalytic Hydrocarbonylation of Arylacetylenes
Authors: Zhao Jiaoyan , Yuan Hongyan , Chen Ruonan , Chen Hongyu , Zhang Yanhua 
Published: December 2021

AbstractAn efficient and environmentally‐friendly synthesis of aryl ketones through the electrochemical catalytic hydrocarbonylation of arylacetylene is demonstrated. The reaction conditions are mild without transition metal catalysts, extra oxidants, or strong acids involved. By using Selectfluor as the additive, this electrochemical transformation exhibits good functional‐group tolerance. The aryl ketone product is obtained with up to 90% isolated yield in the mixed electrolytes of acetonitrile and water. This method may open a new window for the green synthesis of aryl ketones from arylacetylenes.
Tailored highly porous, templated polyurethane for sand consolidation
Authors: Li Wenwen , Chang Fakuen Frank , Eichmann Shannon L. , Liang Feng 
Published: December 2021

AbstractA novel polymeric resin formulation is developed to mitigate sand production from subterranean formations composed of unconsolidated or weakly consolidated sands via a chemical sand consolidation approach. The developed formulation aims to minimize the formation permeability loss commonly observed in a chemical sand consolidation treatment. The new formulation is a water‐in‐oil high internal phase emulsion with poly(ε‐caprolactone) polyol and isophorone diisocyanate monomer incorporated in the external oil phase. Highly porous, emulsion templated polyurethane forms through the reaction between polyol and isocyanate under elevated temperature. Additionally, CO2 generated through the reaction between excess isocyanate monomer and water leads to the formation of more pores in the cross‐linked polymeric network. When the developed formulation is applied for sand consolidation treatment, the interconnected pores formed after resin curing act as “channels” in the consolidated products and allow the produced fluid such as oil, water, or gas to easily flow through, thereby limiting permeability reduction. The effectiveness of using porous polyurethane material for sand consolidation is evaluated through a compressive strength and permeability study of the consolidated sandpacks prepared with this chemistry.
Combined detection of urinary biomarkers noninvasively predicts extent of renal injury in patients with early diabetic kidney disease with kidney qi deficiency syndrome: A retrospective investigation
Authors: Wu Wei , Meng Xian‐Jie , Wan Bing‐Ying , Fang Qi‐Jun , Liu Ying‐Lu , Wang Jie , Fu Yan , Yuan Can‐Can , Wang Mei‐Zi , Chong Fee‐Lan , Wan Yi‐Gang , Shen Shan‐Mei 
Published: December 2021

AbstractIncipient diagnosis and noninvasive forecasts using urinary biomarkers are important for preventing diabetic kidney disease (DKD) progression, but they are also controversial. Previous studies have shown a potential relationship between urinary tubular biomarkers (UTBs) and traditional Chinese medicine (TCM) syndrome in patients with DKD. Thus, we further evaluated the clinical significance of combined detection of urinary biomarkers in noninvasively predicting the extent of renal damage in patients with early DKD with kidney qi deficiency syndrome, and preliminarily explored the potential biological link between UTBs and TCM syndrome in DKD. We categorized 92 patients with Type 2 diabetes mellitus into three groups as follows: 20 patients with normoalbuminuria, 50 patients with microalbuminuria, and 22 patients with macroalbuminuria. We found that, in all groups, 24 hr urinary albumin (24hUAlb) and urinary albumin‐to‐creatinine ratio (UACR) showed stepwise and significant increases. Urinary cystatin C (UCysC), urinary N‐acetyl‐β‐d‐glucosaminidase (UNAG), and urinary retinol‐binding protein (URBP) synchronously increased gradually, consistent with the degree of albuminuria in all groups. Moreover, 24hUAlb and UACR were positively correlated with UCysC, UNAG, and URBP, respectively. In 72 patients with Type 2 DKD with albuminuria, a positive correlation was observed between UNAG and URBP, UCysC was also positively correlated with UNAG and URBP, respectively. Additionally, TCM syndrome distributional characteristics in all patients were consistent with clinical manifestations of kidney qi deficiency syndrome. Therefore, the combined detection of UCysC, UNAG, URBP, and UAlb may be used as a practical clinical technique to noninvasively forecast the extent of renal injury in patients with early Type 2 DKD with kidney qi deficiency syndrome. UTBs may be one of the biological bases of the specific TCM syndromes in DKD.
B Cell Reconstitution Is Strongly Associated With COVID‐19 Vaccine Responsiveness in Rheumatic Disease Patients Who Received Treatment With Rituximab
Authors: Jinich Sarah , Schultz Kaitlin , Jannat‐Khah Deanna , Spiera Robert 
Published: December 2021

ObjectiveTo assess the association of a detectable antibody response to COVID‐19 vaccination with factors including B cell depletion in patients who received treatment with rituximab (RTX).MethodsWe conducted a retrospective review of the charts of adult patients who received treatment with RTX and completed messenger RNA vaccination for SARS–CoV‐2. The primary outcome measure was the presence or absence and strength of the serologic antibody response to vaccination. Comparisons between those with and those without a detectable serologic response were calculated using t‐tests, Fisher's exact test, and Wilcoxon's rank sum test. The relationship between the serologic response to COVID‐19 vaccination and B cell reconstitution status was assessed using negative predictive values and positive predictive values with data reported as percentages with 95% confidence intervals (95% CIs).ResultsIn 56 patients being treated with RTX, a significant difference in terms of the level of B cell reconstitution was observed in those with a positive serologic response compared to those with a negative serologic response to vaccination (proportion of B cells reconstituted among total lymphocytes, median 2% [interquartile range (IQR) 0.13–10%] versus median 0% [IQR 0–0%]; P < 0.001).There was also a significant difference in the time since the last RTX infusion between patients with a positive serologic response compared to those with a negative serologic response to vaccination (median time since last infusion 594 days [IQR 262–1,163] versus median 138 days [IQR 68–197]; P < 0.001). There was no serologic response to COVID‐19 vaccination after the last exposure to RTX in 13% of patients (3 of 24) at >12 months after last exposure, 55% of patients (6 of 11) at 6–12 months after last exposure, and 86% of patients (18 of 21) at <6 months after last exposure.ConclusionB cell reconstitution and a longer time since a patient's last exposure to RTX are associated with a positive serologic response to the COVID‐19 vaccine. Strategies for maximizing vaccine responsiveness in patients who receive treatment with RTX should incorporate assessment of B cell reconstitution.
Detection of SiO2 nanoparticles using triple‐quadrupole inductively coupled plasma‐mass spectrometry for semiconductor applications
Authors: Lim Heung Bin 
Published: December 2021

AbstractDetection method for SiO2 nanoparticles with the size of 20–300 nm was developed using triple‐quadrupole inductively coupled plasma‐mass spectrometer (TQ‐ICP‐MS). As 28Si+ ion of SiO2 nanoparticles is a difficult‐to‐determine ion via ICP‐MS due to severe molecular ion interferences, the mass‐to‐charge ratio of 28Si+ was shifted by reacting with O2 gas to form 28Si16O+. In order to confirm peak identification, a time‐resolved spectrum (TRS) of known standard particle was obtained, and the correlation curve of the average peak area per particle (Y) versus particle radius (X) was plotted after optimized blank subtraction. The function Y = aX3 was fitted to the data, demonstrating the validity of the developed method. As a result, the presence of 20 nm SiO2 nanoparticles, much smaller than the size (<80 nm) published in other articles, was confirmed in this work and the correlation curve can be used for on‐line monitoring of nanoparticles present in the process chemicals of the semiconductor industry.
Effectiveness of narrative therapy on adult attachment styles and expressivity in women experiencing low marital satisfaction
Authors: Ghavibazou Effat , Hosseinian Simin , Abdollahi Abbas , Ghamari Kivi Hossein 
Published: December 2021

AbstractThe present study investigates the effectiveness of narrative therapy on adult attachment styles and expressivity in women experiencing low marital satisfaction. This study was quasi‐experimental. Participants consist of 30 women experiencing low marital satisfaction. They were selected based on availability and randomly designated to an intervention or waiting list group. Narrative therapy was accomplished individually in six 45‐min sessions for the intervention group. Results based on repeated‐measures analysis of variance showed no significant improvement in the intervention group for expressivity and adult attachment. Still, it revealed a considerable improvement during follow‐up in expressivity. Consequently, results indicate that narrative therapy cannot influence adult attachment and expressivity, but a 2‐month follow‐up questionnaire administered indicates improvement in expressivity with a large effect size.
Reactive Extraction of Gluconic Acid Using Trioctylamine in Different Diluents
Authors: Kakku Sivasankar , Gaikwad Shripal M. , Gaikwad Shashank , Taralkar Suyogkumar V. , Billa Sarath Babu , Chakinala Anand Gupta , Chakinala Nandana 
Published: December 2021

AbstractReactive extraction of gluconic acid (GA) from aqueous solutions was investigated using trioctylamine (TOA) as extractant in the presence of benzyl alcohol (BA) and 1‐decanol (DE) as diluents. Physical extraction of GA with pure diluents in the absence of TOA was found to be poor. Reactive extraction with an amine‐diluent mixture enhanced the separation process. Higher extraction efficiencies and distribution coefficients were achieved in the presence of BA as compared to DE. Further optimization studies were carried out to determine the synergistic effect of amine/diluent ratio. Loading ratios higher than 0.5 suggested 3:1 complex formation of GA with the amine. A reactive extraction mechanism of GA in TOA was proposed, and the equilibrium complexation constant was determined.
Multi‐step wind speed and wind power forecasting using variational momentum factor and deep learning based intelligent neural network models
Authors: Subramaniam Nachimuthu Deepa , Banerjee Abhik , Karuppaiah Jayakumar 
Published: December 2021

AbstractDeep learning based novel intelligent neural network models are developed in this research study and employed for performing multi‐step wind speed and wind power forecasting for the data pertaining to certain wind farms. It has always been tedious to predict wind speed and wind power accurately due the existence of non‐linearity in the wind farm data and as well previous traditional and heuristic techniques has their own merits and demerits in performing the prediction process. This research study intends to handle the prevailing non‐linearity of the wind farm data and as well perform prediction of the parameters in a better manner with increased accuracy rate. The prediction study facilitates the renewable energy community to install the wind mills in the locations with higher accuracy rate and thereby power production gets increased extravagantly. The intelligent neural network developed in this article includes the ELMAN and spiking neuronal models with incorporated deep learning procedure and varying momentum factor criterion to achieve minimal error and better accuracy rate. Multi‐step forecasting is carried for 10‐min ahead and the numerical simulation executed with the proposed intelligent non‐linear forecasting techniques. The attained results confirm the superiority of the developed models over other techniques from previous works.
Curriculum theorizing of self‐other for change: To see, to observe, and to contemplate through I‐Ching (The Book of Change)
Authors: Moon Seungho , Guo Wenjin 
Published: December 2021

AbstractThis study is about the curriculum theorizing of self‐other and transformation. The two authors, both of Asian heritage, share their lived experience and interpretations of Chapter 20 of I‐Ching. This paper revisits a conventional, humanistic division of self‐other as a launching pad to challenge the current discourse on cultural diversity and curriculum change. Mainly, the authors revisit the dichotomous understanding of self‐other and challenge modes of curriculum change that are operated by the logic of meritocracy and individual effort. This investigation of I‐Ching opens up its landscape through a conversation about personal and social change, with an epistemological shift from the self‐other binary, thus imagining curriculum implications for a different society. The process of writing narratives is an epistemological healing process in that writing as inquiry helps revalue indigenous intellectual treasures that have been denigrated by Eurocentric ideologies both historically and politically. This examination of I‐Ching, specifically hexagram 20, will provide educators with an innovative epistemological frame that will allow them to review, rethink, challenge, and possibly advance discourses on seeing, change, and self‐other in curriculum and cultural studies.