bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational methods for parametric evaluation of the biventricular mechanics of direct cardiac compression
Authors: Aranda‐Michel Edgar , Waldman Lewis K. , Trumble Dennis R. 
Published: April 2021

AbstractDespite the increasing incidence of heart failure, advancements in mechanical circulatory support have become minimal. A new type of mechanical circulatory support, direct cardiac compression, is a novel support paradigm that involves a soft deformable cup around the ventricles, compressing it during systole. No group has yet investigated the biomechanical consequences of such an approach. This article uses a multiscale cardiac simulation software to create a patient‐specific beating heart dilated cardiomyopathy model. Left and right ventricle (LV and RV) forces are applied parametrically, to a maximum of 2.9 and 0.46 kPa on each ventricle, respectively. Compression increased the ejection fraction in the left and right ventricles from 15.3% and 27.4% to 24.8% and 38.7%, respectively. During applied compression, the LV freewall thickening increased while the RV decreased; this was found to be due to a change in the balance of the preload and afterload in the freewalls. Principal strain renderings demonstrated strain concentrations on the anterior and posterior LV freewall. Strains in these regions were found to exponentially increase after 0.75 normalized LV force was applied. Component analysis of these strains illuminated a shift in the dominating strain from transmural to cross fiber once 0.75 normalized LV force is exceeded. An optimization plot was created by nondimensionalizing the stroke volume and maximum principal strain for each compression profile, selecting five potential compression schemes. This work demonstrates not only the importance of a computational approach to direct cardiac compression but a framework for tailoring compression profiles to patients.
Successful laparoscopic resection of gastric lymphangioma under the intraoperative guidance of indocyanine green fluorescence imaging: A case report
Authors: Umino Ryosuke , Urabe Masayuki , Ohkura Yu , Haruta Shusuke , Ueno Masaki , Udagawa Harushi 
Published: April 2021

AbstractGastric lymphangioma (GLA) is an extremely rare tumor without an established therapeutic strategy. Surgical resection is considered the mainstay of treatment, although there is a high risk of local recurrence if negative margins are not achieved. A 51‐year‐old man underwent routine abdominal ultrasonography, which incidentally detected a 20‐mm tumor adjacent to the lesser curvature of the stomach. GLA was suspected based on its polycystic appearance. After a 16‐month monitoring period, laparoscopic resection was performed because of tumor growth and involvement of the left gastric artery. Intraoperative indocyanine green (ICG) navigation system revealed lymphatic drainage from the tumor, which we used to help determine the optimal excision line and minimize the loss of gastric volume. Pathological examination confirmed complete resection with negative margins and supported a diagnosis of lymphangioma. We performed laparoscopic radical resection of GLA under guidance from intraoperative ICG fluorescence imaging, which allowed us to maximize residual gastric volume.
Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential
Authors: Batta Gyula , Kárpáti Levente , Henrique Gabriela Fulaneto , Tóth Gabriella , Tarapcsák Szabolcs , Kovacs Tamas , Zakany Florina , Mándity István M. , Nagy Peter 
Published: April 2021

Background and PurposeCell penetrating peptides are promising tools for delivery of cargo into cells, but factors limiting or facilitating their cellular uptake are largely unknown. We set out to study the effect of the biophysical properties of the cell membrane on the uptake of penetratin, a cell penetrating peptide.Experimental ApproachUsing labelling with pH‐insensitive and pH‐sensitive dyes, the kinetics of cellular uptake and endo‐lysosomal escape of penetratin were studied by flow cytometry.Key ResultsWe report that escape of penetratin from acidic endo‐lysosomal compartments is retarded compared with its total cellular uptake. The membrane dipole potential, known to alter transmembrane transport of charged molecules, is shown to be negatively correlated with the concentration of penetratin in the cytoplasmic compartment. Treatment of cells with therapeutically relevant concentrations of atorvastatin, an inhibitor of HMG‐CoA reductase and cholesterol synthesis, significantly increased endosomal escape of penetratin in two different cell types. This effect of atorvastatin correlated with its ability to decrease the membrane dipole potential.Conclusion and ImplicationsThese results highlight the importance of the dipole potential in regulating cellular uptake of cell penetrating peptides and suggest a clinically relevant way of boosting this process.
Re‐examining the implications of COVID‐19 on the Canadian dairy and poultry sectors
Authors: Weersink Alfons , von Massow Michael , McDougall Brendan , Bannon Nicholas 
Published: April 2021

AbstractThe dairy and poultry sectors responded quickly to the initial adjustments in the quantity and nature of food products forced by the shuttering of the hospitality sector and the subsequent switch to buying food from grocery stores. In addition, these sectors were less affected by the labor availability and health issues from COVID‐19 (coronavirus disease‐2019) that plagued others, such as red meat processors. While the overall impacts were less than most other parts of the agri‐food system, some elements of supply managed products, particularly poultry processors, have experienced a reduction in returns and are still adjusting to the new demand and supply situation. The extent of the impact is correlated with the degree to which the supply chain further upstream was connected to the downstream hospitality sector.
Prognostic value of nerve ultrasonography: A prospective multicenter study on the natural history of chronic inflammatory neuropathies
Authors: Telleman Johan A. , Herraets Ingrid J. T. , Goedee Hendrik Stephan , van Eijk Ruben P. A. , Verhamme Camiel , Eftimov Filip , Lieba‐Samal Doris , Asseldonk Jan Thies van , van den Berg Leonard H. , van der Pol Willem Ludo , Visser Leo H. 
Published: April 2021

AbstractBackground and objectiveNerve ultrasound is a promising new tool in chronic inflammatory neuropathies. The aim of this study was to determine its prognostic value in a prospective multicenter cohort study including incident and prevalent patients with CIDP and MMN.MethodsWe enrolled 126 patients with CIDP, and 72 with MMN; 71 were treatment‐naive. Patients with chronic idiopathic axonal polyneuropathy (CIAP; n = 35) were considered as disease controls. Standardized neurological examination, questionnaires, and nerve ultrasonography were obtained at time of inclusion and 1‐year follow‐up. Nerve size development over time and correlation between nerve size and clinical outcome measures were determined using linear mixed effects models.ResultsNerve size development over time was heterogeneous. Only in MMN was there a correlation between C5 nerve root size and deterioration of grip strength (−1.3 kPa/mm2 (95% confidence interval [CI] −2.3 to −0.2). No other significant correlations between nerve size and clinical outcome measures were found. In MMN, presence of nerve enlargement at inclusion predicted deterioration of grip strength, and MMN patients with enlargement confined to the brachial plexus seemed to have more favorable outcomes. No other predictive effects of sonographic nerve size were found.ConclusionsThe present study indicates that the natural course of nerve size development in CIDP and MMN is heterogeneous, and that the prognostic value of sonographic nerve enlargement is limited. It had some predictive effect in patients with MMN. Further research in specific subgroups of chronic inflammatory neuropathy is necessary to determine the usefulness of nerve ultrasonography after the diagnostic phase.
Motion‐triggered laser photography reveals fine‐scale activity patterns for burrowing crayfish
Authors: Bearden Rebecca A. , Tompkins Emily M. , Huryn Alexander D. 
Published: April 2021

Abstract

Burrowing crayfish represent 15% of total crayfish species and 32% of imperilled species. Few life history studies exist for these species and more information is needed regarding their ecology, population status, distribution, and biogeography for effective conservation efforts. Challenges to gaining such information include sampling difficulty and small sample sizes. Collection efforts may be more efficient if activity patterns can be identified for species of interest. The goal of our study was to assess specific environmental indicators of burrowing crayfish activity patterns.

We evaluated activity patterns of two primary burrowing crayfish species, Lacunicambarus erythrodactylus (Simon & Morris, Proc. Biol. Soc. Wash., 127, 2014, 572) and Procambarus holifieldi (Schuster, Taylor, & Adams, Zootaxa, 4021, 2015, 1) using laser‐triggered digital photography for one‐year periods in the Bogue Chitto Creek floodplain, Dallas County, Alabama, U.S.A. We predicted that activity would be related to time of day, season, groundwater depth, and precipitation.

Activity by L. erythrodactylus covaried significantly with time of day, daylength, groundwater temperature, and relative air temperature, while activity by P. holifieldi covaried with time of day, season, groundwater temperature, and relative air temperature. Additionally, burrow chimney construction by P. holifieldi covaried with daylength, groundwater temperature, relative air temperature, and precipitation.

Out‐of‐burrow activity for both species was greatest at night and during periods of relatively cool groundwater temperatures and relatively warm air temperatures, which may be linked to thermal regulation behaviour. The probability of chimney construction by P. holifieldi increased with increasing daylength and decreasing precipitation and was highest during periods of cool groundwater temperatures and air temperatures. A distinct lull in activity from October through March for both species was likely to be the result of reproductive behaviours such as period of egg production and incubation within burrows.

Identifying peak out‐of‐burrow activity periods for burrowing crayfish will allow collection efforts to be focused on periods of greatest activity, thereby facilitating the study of burrowing crayfish behaviour.
Adjustable iron‐containing SiBCN ceramics with high‐temperature microwave absorption and anti‐oxidation properties
Authors: Song Yan , Jin Shuo , Hu Ketao , Du Yuzhang , Liang Jin , Kong Jie 
Published: April 2021

AbstractQuaternary siliconboron carbonitride (SiBCN) ceramics show excellent high‐temperature stability and oxidation resistance, indicating great potential as high‐temperature electromagnetic (EM) wave absorbing materials. In this contribution, an efficient and facile method was developed to prepare bulk iron‐containing SiBCN (Fe–SiBCN) ceramics with remarkable EM wave absorption at high temperature by pyrolyzing boron and iron containing precursors (PSZV‐B–Fe). The introduction of boron and iron not only improves the high‐temperature stability but also influences the complex permittivity and EM wave absorption. The minimum reflection coefficient (RCmin) is −61.05 dB, and the effective bandwidth absorption (EAB) is 3.35 GHz (9.05–12.4 GHz). The RCmin will be decreased to −52.3 dB at 600°C as well as the EAB covers more than 67% of the X band (2.8 GHz). The high‐temperature stable Fe–SiBCN ceramics with adjustable dielectric properties can be utilized as high‐performance EM wave‐absorbing materials in high‐temperature and harsh environments.
Negative pressure wound therapy for surgical site infections: A systematic review and meta‐analysis
Authors: Gao Junru , Wang Yunyun , Song Jingyu , Li Ze , Ren Jianan , Wang Peige 
Published: April 2021

AbstractObjectiveNegative pressure wound therapy is one of the most common treatments for infected wounds. The aim of this meta‐analysis was to compare the efficacy of negative pressure wound therapy with conventional treatment methods in the treatment of surgical site infection.DesignThis study is registered with International Prospective Register of Systematic Reviews.Data SourcesThe Pubmed, Embase and the Cochrane Central Register of Controlled Trials databases were searched.MethodsThe systematic review was searched by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses method. All trials reporting the use of negative pressure wound therapy for surgical site infection treatment were included regardless of surgery type. The primary outcome measure was wound healing. Secondary outcomes were length of hospital stay, medical costs, adverse events, and reoperation rates. Results are presented with 95% confidence intervals and report estimates as odds ratios. Heterogeneity was determined through theI2test, withI2 > 50% indicating substantial heterogeneity andp < .10 significance. The search was performed on 10 March 2020.ResultsWe identified 13 eligible trial comparisons, of which 2 were randomized controlled trials and 11 cohort study. Negative pressure wound therapy in surgical site infection (SSI) patients significantly increased wound healing rate, accelerated wound healing time, increased daily wound healing area, reduced hospital stay, and reduced adverse events. However, negative pressure wound therapy was associated with increased medical costs.ConclusionNegative pressure wound therapy may be more effective for the treatment of surgical site infection relative to conventional debridement, dressings and other treatments. However, further high‐quality randomized controlled trials are needed to determine the most optimal application of negative pressure wound therapy.Impact.Negative pressure wound therapy is the best treatment strategy for surgical site infection. This study can improve medical practitioners’ awareness of negative pressure wound therapy for surgical site infection, promoting the development of relevant randomized controlled trials.
Multidimensional family development theory: A reconceptualization of family development
Authors: Scott Crapo J. , Bradford Kay 
Published: April 2021

AbstractAs one of the first true family theories, family development theory helps explain competing and complimentary development among family members. However, assumptions of universality and other limitations have reduced its usefulness. We propose multidimensional family development theory, a reconceptualization that includes modifications to increase utility and usability for researchers and practitioners alike. From previously composite stages, we derive four dimensions of development: personal, vocational, couple, and generative. We discuss each dimension, the relationship of dimensions within individuals, and how the dimensions exert reciprocal influence individually and across the entire family. Mechanisms for the development of the individual and family are put forth. Roles and stages are discussed within the context of the developmental dimensions. The role and influence of culture is explicated. Links between process and diversity in terms of development are posited. We discuss how the theory can be applied in research and clinical settings.
Inventory Management, Dealers' Connections, and Prices in Over‐the‐Counter Markets
Authors: COLLIARD JEAN‐EDOUARD , FOUCAULT THIERRY , HOFFMANN PETER 
Published: April 2021

ABSTRACTWe propose a new model of trading in over‐the‐counter markets. Dealers accumulate inventories by trading with end‐investors and trade among each other to reduce their inventory holding costs. Core dealers use a more efficient trading technology than peripheral dealers, who are heterogeneously connected to core dealers and trade with each other bilaterally. Connectedness affects prices and allocations if and only if the peripheral dealers' aggregate inventory position differs from zero. Price dispersion increases in the size of this position. The model generates new predictions about the effects of dealers' connectedness and dealers' aggregate inventories on prices.
A survey of Japanese interns to prepare for mandatory clinical training in obstetrics and gynecology
Authors: Onodera Yohei , Matoba Yusuke , Suemitsu Tokumasa , Shinagawa Manaka , Sugita Yosuke , Mayama Michinori , Banno Kouji , Yanaihara Nozomu , Komatsu Hiroaki , Shozu Makio , Watari Hidemichi 
Published: April 2021

AbstractAimObstetrics and gynecology (Ob/Gyn) training became compulsory for Japanese physician interns from April 2020 to improve medical competence in treating women's diseases. This study aims to understand the Ob/Gyn training needs of postgraduate year 1–2 physicians (interns) and thereby improve training efficiency.MethodsThis study was administered to interns at Ob/Gyn training facilities from December 2019 to February 2020. An original questionnaire was used to evaluate their assessment of training needs. In analyses, interns were categorized according to whether they were willing to major in Ob/Gyn.ResultsOf the 1154 participants, 163 (14.1%) would major in Ob/Gyn (Ob/Gyn applicants) and 967 (83.8%) would not (non‐Ob/Gyn applicants). At the time of the survey, 634 (54.9%) had rotated in Ob/Gyn, 253 (21.9%) planned to rotate, and 267 (23.1%) chose not to rotate. The two most favorable training experiences were “experience in surgical procedures” (81/141, 57.4%) and “wide treatment areas covered by Ob/Gyn” (78/141, 55.3%) among the Ob/Gyn applicants, and “specificity of women's treatment” (308/488, 63.1%) among the non‐Ob/Gyn applicants.ConclusionsOb/Gyn applicants and non‐Ob/Gyn applicants differed in their assessment of Ob/Gyn rotations. It is crucial to provide medical training based on interns' needs to improve their skills for treating female patients.
Stakeholder Management & The Value of Human‐Centred Corporate Objectives
Authors: Parmar Bidhan (Bobby) L. , Wicks Andrew C. , Freeman R. Edward 
Published: April 2021

AbstractWe appreciate the opportunity to revisit the conversation about corporate objectives by responding to Goranvoa and Ryan’s (2021) paper, which focuses on the trends that impact shareholders and their relationship with firms. We structure our response to the authors in the following way: First, we argue that the governance challenges raised by Goranova and Ryan, in so far as they impact firms, make a case for stakeholder management. Second, we point out two shareholder‐centric trends the authors fail to describe, which also support stakeholder management. In the third section, we respond directly to the authors’ claim that competitive advantage is a more useful focus for the corporate objective by 1) noting that the authors utilize a strawman conceptualization of stakeholder theory in their argument, 2) detailing the existing strategy literature that connects competitive advantage and stakeholder relationships, and 3) arguing that competitive advantage is not sufficient, it needs to be augmented with a stakeholder focused cooperative advantage. Together, our response to the authors and the larger stakeholder perspective on corporate objectives offer a much‐needed human‐centric lens on how people coordinate their actions to create and trade value.
Effect of Air‐Particle Abrasion Protocol and Primer on The Topography and Bond Strength of a High‐Translucent Zirconia Ceramic
Authors: Khanlar Leila Nasiry , Takagaki Tomohiro , Abdou Ahmed , Inokoshi Masanao , Ikeda Masaomi , Takahashi Akifumi , Yoshihara Kumiko , Nagaoka Noriyuki , Nikaido Toru , Blatz Markus B. , Tagami Junji 
Published: April 2021

AbstractPurposeTo evaluate effect of air‐particle abrasion protocol and primer on surface topography and bond strength of resin cement to high‐translucent zirconia ceramics.Materials and MethodsTwo hundred disk‐shaped high‐translucent zirconia specimens of 5Y‐PSZ were prepared. The specimens were assigned to 5 groups in terms of particle type and air‐particle abrasion pressure: (1) control, (2) alumina with 0.2 MPa‐air pressure [AB‐0.2], (3) alumina with 0.4 MPa‐air pressure [AB‐0.4], (4) glass beads with 0.2 MPa‐air pressure [GB‐0.2], and (5) glass beads with 0.4 MPa‐air pressure [GB‐0.4]. Two different primers 1% MDP (Experimental) and MDP‐silane primer (Clearfil Ceramic Primer Plus) was also tested. Stainless steel rods were bonded to the 5Y‐PSZ specimens with PANAVIA V5. For each group, the tensile bond strength (TBS) was measured after 24‐hour water storage (n = 10) and after 5000 thermal‐cycling (n = 10) at crosshead speed of 2 mm/min. The data were statistically analyzed using Weibull analysis. Surface roughness (Sa) was measured using a 3D‐Laser Scanning Confocal Microscope (n = 5) and analyzed by t‐test with Bonferroni correction. Surface topography using scanning electron microscopy (SEM) and surface elemental analysis using energy dispersion spectroscopy (EDX), and cross‐section SEM at the interface with composite cement were also investigated.ResultsIn MDP‐silane groups, the highest TBS was observed in AB‐0.4 after 24 hours and GB‐0.4 after thermal‐cycling (p < 0.05). In MDP groups, AB groups resulted in the significantly higher TBS than GB groups (p < 0.05). AB‐0.4 group showed the highest Sa value compared to all groups (p < 0.005), meanwhile GB groups did not show different Sa compared to control (p > 0.005).ConclusionAir‐abrasion with different particle and blasting pressure can improve bonding to zirconia with proper primer selection. Particularly, glass beads abrasion followed by MDP‐silane primer and alumina abrasion followed by MDP primer alone provided stable bond strength of resin cement to high‐translucent zirconia after aging. High‐translucent zirconia abraded with glass beads achieves a desirable bonding performance without creating surface microcracks which may hinder zirconia's mechanical properties.
Xylem vessel‐specific SND5 and its homologs regulate secondary wall biosynthesis through activating secondary wall NAC binding elements
Authors: Zhong Ruiqin , Lee Chanhui , Haghighat Marziyeh , Ye Zheng‐Hua 
Published: April 2021

Summary

Secondary cell wall biosynthesis has been shown to be regulated by a suite of transcription factors. Here, we identified a new xylem vessel‐specific NAC domain transcription factor, secondary wall‐associated NAC domain protein5 (SND5), in Arabidopsis thaliana and studied its role in regulating secondary wall biosynthesis.

We showed that the expression of SND5 and its close homolog, SND4/ANAC075, was specifically associated with secondary wall‐containing cells and dominant repression of their functions severely reduced secondary wall thickening in these cells. Overexpression of SND4/5 as well as their homologs SND2/3 fused with the activation domain of the viral protein VP16 led to ectopic secondary wall deposition in cells that are normally parenchymatous. SND2/3/4/5 regulated the expression of the same downstream target genes as do the secondary wall NAC master switches (SWNs) by binding to and activating the secondary wall NAC binding elements (SNBEs).

Furthermore, we demonstrated that the poplar (Populus trichocarpa) orthologs of SND2/3/4/5 also activated SNBEs and regulated secondary wall biosynthesis during wood formation.

Together, these findings indicate that SND2/3/4/5 and their poplar orthologs regulate the expression of secondary wall‐associated genes through activating SNBEs and they are positioned at an upper level in the SWN‐mediated transcriptional network.