bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Questionnaire Survey Method in Medicine on the Example of Treatment Adherence Scales
Authors: Lukina Yu. V. , Kutishenko N. P. , Martsevich S. Yu. , Drapkina O. M. 
Published: September 2021

Aim. Development, testing and validation of the original questionnaire “Adherence Scale” (AS) in the PRIORITY and ANTEY observational studies (OS).Materials and methods. The OS PRIORITY assessed adherence to statins in 298 patients with high and very high cardiovascular risk for 3 months. The OS ANTEY assessed adherence to oral anticoagulants in 201 patients with non-valvular atrial fibrillation for 1 year. Adherence was assessed using the original AS questionnaire, for which external validation was performed (with the calculation of the Cohen's Kappa coefficient). The reference methods were the validated questionnaire and direct medical interview. And internal validation was performed (consistency of questions on the AS using Spearman's correlation analysis). The sensitivity, specificity (ROC analysis) and retest reliability of the adherence scale (Cronbach's alpha) were also determined.Results. In the OS PRIORITY Cohen's kappa for the AS and the reference method of direct medical survey was 0.76 (high consistency), and for the AS and the reference method of the validated questionnaire=0.28 (low consistency). High internal consistency of the questionnaire questions (correlation coefficient=0.78, p<0.0001) confirms the internal validity of the adherence scale. Evaluation of the main characteristics of the modified AS in the OS ANTEY showed high consistency between the results of the AS and the validated questionnaire: Cohen's kappa=0.94 (high external validity of the AS). The retest reliability of the AS was 0.76 (Cronbach's alpha). The internal consistency of the questionnaire was confirmed by a strong and statistically significant correlation between the test questions: Spearman's correlation coefficient=0.80, p<0.0001. The sensitivity of the test, determined using the ROC analysis, was 89%, and the specificity was 62%.Conclusion. The developed and tested new original questionnaire (modified version) – the AS – showed high indicators of reliability, validity and sensitivity. This ensures its reliability and ease of use for assessing various types of adherence and determining the leading factors of non-adherence, and also allows its use in scientific studies and clinical practice.
Association of smoking with indicators of the structure and function of left ventricle of the heart in middle-aged men
Authors: Isaykina O. Yu. , Rozanov V. B. , Aleksandrov A. A. , Kotova M. B. , Isaykina M. A. , Drapkina O. M. 
Published: September 2021

Aim. Evaluation of the association of smoking (status, intensity and duration) with indicators of the structure and function of the left ventricle of the heart in a sample of middle-aged men.Material and methods. This study is part of a 32-year prospective cohort observation of men from childhood (11-12 years). 301 (30.0%) representatives of the original population sample aged 41-44 years were included in the study. The examination included a survey on intensity of smoking, anthropometry, measuring blood pressure, pulse rate, echocardiography, and blood lipid analysis.Results. 301 men aged 41-44 included 92 (30.6%) men who had never smoked, 73 (24.3%) men smoked in the past and 136 (45.2%) men currently smoke. 75% of current smokers started smoking before age 19, of which 32.3% started smoking before age 15. The duration of smoking cessation among former smokers was 14.4 (12.5; 16.2) years. The average duration of smoking [average (95% confidence interval)] among former smokers was 14.4 (12.5; 16.2), for current smokers – 25.3 (24.6; 26.0) years. Current smoking was statistically significantly associated with higher mean values of the left ventricular myocardium mass (LVMM), the left ventricular myocardial mass index (LVMMI), the end-systolic and end-diastolic interventricular septum thickness (IVSTs/IVSTd), the end-systolic left ventricular posterior wall thickness (LVPWs), and the intensity and duration of current smoking were associated with higher values of the relative wall thickness of the left ventricle, the end-diastolic interventricular septum thickness, the end-systolic interventricular septum thickness, and with low values of the left ventricular stroke volume index (LV SVI). Multiple regression analysis showed that current smoking has an independent effect on the left ventricular myocardium mass, the left ventricular myocardial mass index and the end-diastolic interventricular septum thickness, and the duration and intensity of smoking has an effect on the index of the left ventricular stroke volume index.Conclusion. Current smoking, duration and intensity in middle-aged men is associated with unfavorable changes in indicators of the structure and function of the left ventricle of the heart. Efforts for primary prevention of smoking should begin as early as childhood and continue into adolescence and young adulthood.
Evaluation of the Influence of <i>CYP2C9* 2, CYP2C9*3</i> Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery
Authors: Morozova T. E. , Shatsky D. A. , Shikh N. V. , Shikh E. V. , Andrushchyshina T. B. , Lukina M. V. , Kachanova A. A. , Sozaeva Zh. A. , Shuev G. N. , Denisenko N. P. , Grishina E. A. , Sychev D. A. 
Published: September 2021

Aim. The aim of the study was to evaluate the efficacy and safety of ketoprofen as an analgesic therapy in patients with CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910 gene polymorphisms after cardiac surgery.Material and methods. The study included 90 patients. Postoperative analgesia was perfomed by ketoprofen 100 mg intramuscularly twice daily. The evaluation of pain was determined daily by Numeric Rating Scale for 5 days after cardiac surgery. The safety of ketoprofen was determined by assessing the severity of gastroenterological symptoms using the Gastrointestinal Symptom Rating Scale questionnaire and determining the frequency of episodes of acute kidney injury. The material for DNA was venous blood. To determine the single nucleotide genetic polymorphisms CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910, the real-time polymerase chain reaction was used.Results. In patients with the AA genotype of CYP2C9*3 polymorphism, the intensity of pain on the numeric rating scale scale (points) was significantly higher than in patients with the AC genotype: 7 [6; 8] vs 6 [5; 6] (р=0,003), 7 [6; 8] vs 6 [5; 6] (р=0,04), 6 [5; 7] vs 5 [4; 5] (р=0,04), 5 [3; 6] vs 3 [3; 4] points (р=0,02) on days 1, 2, 3 and 5 of the postoperative period, respectively. The severity of gastroenterological symptoms was higher in patients with a heterozygous CT genotype for the allelic variant CYP2C9*2 than in patients with a wild CС genotype and amounted to 19 [19; 22] vs 18 [16; 20] points, respectively, (p=0,04). The distribution of genotypes for CYP2C9*2 polymorphisms and CYP2C9*3 polymorphisms between the groups of acute renal injury did not differ significantly.Conclusion. Associations of polymorphisms CYP2C9*3 with a lower intensity of pain syndrome and CYP2C9*2 with a greater severity of gastroenterological symptoms were revealed.
Effect of Direct Oral Anticoagulants for Ulcer Epithelization and Laser Doppler Flowmetry Parameters In Patients with Diabetic Foot Syndrome and Atrial Fibrillation
Authors: Petrov V. I. , Rogova N. V. , Кuzmina T. N. , Lishuta A. S. 
Published: September 2021

Aim. To study changes in epithelialization of diabetic foot ulcers and parameters of laser Doppler flowmetry (LDF) in patients with diabetic foot syndrome (DFS) and atrial fibrillation (AF) during complex therapy with the addition of direct oral anticoagulants (DOAC).Material and methods. An open-label comparative randomized study in parallel groups was performed. Patients with neuroischemic DFS and persistent FA without previous anticoagulant therapy were randomized into two groups: combination therapy for DFS and rivaroxaban (group 1; n=24) or combination therapy for DFS and dabigatran (group 2; n=22). Changes in local status in diabetic foot ulcers, coagulogram parameters and LDF were studied at 4 and 12 weeks.Results. Complete epithelialization of diabetic foot ulcers after 12 weeks was found in 14 (58.3%) patients in group 1, and in 10 (45.4%) patients in group 2. Statistically significant improvements in LDF parameters were found in both groups in both groups: an increase in the microcirculation index by 53.5% (p=0.02), pulse wave by 124.0% (p=0.003), respiratory wave by 59.4% (p=0.007) was found in group 1. An increase in the microcirculation index by 48.5% (p=0.02), pulse wave by 73.1% (p=0.003), respiratory wave by 47.1% (p=0.03) were found in group 2.Conclusion. Positive statistically significant changes in epithelialization of diabetic foot ulcers and LDF parameters were found in patients with DFS and AF during 12 weeks of complex therapy with the addition of DOACs (rivaroxaban and dabigatran). Further research for DOACs in DFS patients is needed.
Association of SCN5A gene polymorphism with dilated cardiomyopathy
Authors: Nikulina S. Yu. , Kuznetsova O. O. , Chernova A. A. , Matyushin G. V. , Gurazheva A. A. , Maksimov V. N. 
Published: September 2021

Subjects and methods. The study included patients with IDC (group 1; n=111, 89.2% men, average age 51.7±9.7 years) and ICM (group 2; n=110, 91.5% men, average age 58.7±8.4 years). All patients (IDC and ICM) underwent coronary angiography. Based on the anamnesis data and instrumental studies, those patients who could be said to have no risk factors for the development of dilatation of the heart cavities were identified in the group 1. And those patients who were reliably diagnosed with coronary artery disease were in the group 2, that is, dilatation of the heart cavities is due to a previous myocardial infarction, existing angina pectoris. The control group (n=121, average age 53.6±4.8 years) included patients who had no manifestations of cardiovascular diseases. The patients underwent laboratory and instrumental studies, as well as molecular and genetic studies of the A/G polymorphism of the SCN5A gene (rs1805124).Results. In the group with IDC 51.4% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype-40.5%, and the rare homozygous GG genotype-8.1%. In the control group 63.3% of patients were identified as carriers of a homozygous genotype by a common allele, and 33.5% were carriers heterozygous genotype, and homozygous genotype for a rare allele – 3.2%. The analysis revealed a statistically significant decrease in the frequency of carrying the homozygous AA genotype in patients with IDC compared to the control group of the rs1805124 polymorphism of the SCN5A gene. In the group of patients with ICM, the А allele (69.5% vs. 80.1%, p=0.003) and the AA genotype (50.9% vs. 63.3%, p=0.030) were significantly less common than in the control group. The rare homozygous GG genotype was statically more common in patients with ICM compared to the control group (11.8% vs. 3.2%, p=0.004). Also, the G allele in the group of patients with ICM was detected statically significantly more often than in the control group (30.5% vs. 19.9%, p= 0.003).Conclusion. The polymorphic locus rs1805124 of the SCN5A gene is associated with both IDC and ICM. Homozygous genotype AA and allele A are conditionally protective factors for the development of these conditions in men.
How Significantly to Emerging Economies Benefit From Board Attributes and Risk Management in Enhancing Firm Profitability?
Authors: Tariq Tawfeeq Yousif Alabdullah  , Essia Ries Ahmed  , Mohammed Almashhadani  , Sara Kadhim Yousif  , Hasan Ahmed Almashhadani  , Raghad Almashhadani  , Eskasari Putri  
Published: September 2021

Recently, the literature review represented by its previous studies have witnessed obvious development that has been become the reason to create different trends. This paper aims to considerably contribute to the area of corporate governance to be then involved in the new trends testing the role of board attributes as mechanisms of corporate governance to know whether non-financial companies in the developing economies will benefit from these mechanisms in their impact of firm profitability. Thus, the present study tested 100 non-financial companies based on their annual reports in the year of 2020 as a cross sectional study. The results of testing the variables of the current study revealed that there is a negative link between board of directors size and profitability. On the other hand, the results showed that the managers independency has no relationship with profitability. Likewise, the results revealed that risk management has no effect on profitability. This study probably could be considered as a unique study due to its new contribution that fills the gap of what have been done in the previous studies in the area of corporate governance (CG) and profitability because it tested the link between risk management and growth. Hence, according to the researchers’ knowledge, there is no research that has been dealt with the two variables that were dealt by the current study. The current study introduces evidence to many parties, such as shareholders, scholar, executives and policy makers.
E-Learning during COVID-19 Pandemic: Turning a Crisis into Opportunity
Authors: Hani Amjad Bani , Hijazein Yazan , Hadadin Hiba , Jarkas Alma , Al-Tamimi Zahraa , Amarin Marzouq , Shatarat Amjad , Abeeleh Mahmoud Abu , Al-Taher Raed 
Published: September 2021

Abstract
Objectives: To assess the medical students' satisfaction and knowledge attainment through distant learning during the COVID-19 pandemic.Methods: This is a cross-sectional, self-reported, questionnaire-based study that was conducted at the School of Medicine at the University of Jordan in April 2020. The targeted population was the students at the school of medicine. An online questionnaire was created using Google Forms. Satisfaction and knowledge attainment among students were assessed using independent-samples t-test.Results: A total of 1000 medical students completed the survey, 506 (50.6%) basic science students and 494 (49.4%) were clinical science students. 655 (65.5%) of all students were either satisfied, or neutral with e-learning and 63.6% of basic science students and 59.5% of clinical students stated that they gained and understood knowledge the same or better than they did before initiation of exclusive e-learning. Satisfaction and knowledge gain were significantly affected by student preparedness (p<0.000), teacher performance (p<0.000), and website accessibility (p<0.000).Conclusion: Transition from traditional in-class teaching to distant learning, whether full or blended, is an inevitable step., In our sample, students were generally satisfied with e-learning and the knowledge attained using it. There was a significant relation between satisfaction and attainment and preparedness of students, teachers, and the medical school.
Effectiveness of the toxin-degrading strain screening strategy: Deficiency and improvement in screening the gossypol-degrading microorganism Aspergillus niger
Authors: Zhang Chen , Shu Gangqin , Wang Hui , Li Daojie , Xü Yuan , Zhang Yunhua , Cheng Maoji Cheng , Chen Lijuan 
Published: September 2021

Abstract
The effectiveness of the classic screening strategy was verified, by duplicating and verifying the degradation of gossypol by the Aspergillus niger. It can reduce the free gossypol content through biosorption but has no effect on the total gossypol content and cannot effectively degrade gossypol. And the most interesting thing we found the strain can secrete agarase, utilise agar as carbon source. In this case, that will mislead researchers and lead them to make wrong judgments. That turns out the usual methods of previous screening strategies are not rigorous enough, the classic screening method has defect in screening toxin-degrading strain, so agar control group should be added. In this study, some suggestions are put forward to optimise the same type of experiments and broaden the idea of detoxification by microorganisms and provide reference for screening effective toxin-degrading microorganisms.
A generalised approach on kerf geometry prediction during CO2 laser cut of PMMA thin plates using neural networks
Authors: Kechagias John Dimitrios , Ninikas Konstantinos , Stavropoulos Panagiotis , Salonitis Konstantinos 
Published: September 2021

Abstract
This study presents an application of feedforward and backpropagation neural network (FFBP-NN) for predicting the kerf characteristics, i.e. the kerf width in three different distances from the surface (upper, middle and down) and kerf angle during laser cutting of 4 mm PMMA (polymethyl methacrylate) thin plates. Stand-off distance (SoD: 7, 8 and 9 mm), cutting speed (CS: 8, 13 and 18 mm/sec) and laser power (LP: 82.5, 90 and 97.5 W) are the studied parameters for low power CO2 laser cutting. A three-parameter three-level full factorial array has been used, and twenty-seven (33) cuts are performed. Subsequently, the upper, middle and down kerf widths (Wu, Wm and Wd) and the kerf angle (KA) were measured and analysed through ANOM (analysis of means), ANOVA (analysis of variances) and interaction plots. The statistical analysis highlighted that linear modelling is insufficient for the precise prediction of kerf characteristics. An FFBP-NN was developed, trained, validated and generalised for the accurate prediction of the kerf geometry. The FFBP-NN achieved an R-all value of 0.98, in contrast to the ANOVA linear models, which achieved Rsq values of about 0.86. According to the ANOM plots, the parameter values which optimize the KA resulting in positive values close to zero degrees were the 7 mm SoD, 8 mm/s CS and 97.5 W LP.
Dirac Equation Redux by Direct Quantization of the 4-Momentum Vector
Authors: Andoni S. 
Published: September 2021

Abstract
Dirac equation (DE) is a cornerstone of quantum physics. We prove that direct quantization of the 4-momentum vector p with modulus 𝑚𝑐 (𝑚 is rest mass) yields a coordinate-free and manifestly covariant equation. In coordinate representation, this is equivalent to DE with spacetime frame vectors xμ replacing Dirac’s γμ -matrices. Remember that standard DE is not manifestly covariant. The two sets {xμ}, {γμ} obey to the same Clifford algebra. Adding an independent Hermitian vector x5 to the spacetime basis {xμ} allows to accommodate the momentum operator in a real vector space with a complex structure generated alone by vectors and multivectors. The real vector space arising from the action of the Clifford product onto the quintet {xμ , x5 } has dimension 32, the same as the equivalent real dimension for the space of Dirac matrices. x5 proves defining for the combined CPT symmetry, axial vs. polar vectors, left and right handed rotors & spinors, etc.; therefore, we name it reflector and {xμ , x5 } – a basis for spacetime-reflection (STR). The pentavector 𝐼 ≡ x05123 in STR substitutes the imaginary unit i. We develop the formalism by deriving all the essential results from the novel STR DE: conserved probability currents, symmetries, nonrelativistic approximation and spin 1/2 magnetic angular momentum. It will become clear that key symmetries follow more directly and with clearer geometric interpretation in STR than in the standard approach. In simple terms, we demonstrate how Dirac matrices are a redundant representation of spacetime-reflection directors.
Variations of the Precipitation Extremes over the Guangdong-Hong Kong-Macao Greater Bay Area in China
Authors: Li Xianru , Wei Zhigang , Wang Huan , Ma Li , Guo Shitong 
Published: September 2021

Abstract
By using the gridded 0.25°×0.25° observation dataset of CN05.1 provided by the China Meteorological Administration, this study investigates the variations of the nine precipitation extreme indices over the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) in China in the period from 1961 to 2018. Based on trends and inter-annual variations, the nine kinds of extreme precipitation are classified into four categories: the category 1 is the very wet days (R95P), the extremely wet days (R99P), the maximum 1-day precipitation amount (RX1day) and the maximum 5-day precipitation amount (RX5day). The category 2 is the number of heavy precipitation days (R10day), the number of very heavy precipitation days (R20day) and the simple daily intensity index (SDII). The category 3 and 4 is the consecutive wet days (CWDday) and the consecutive dry days (CDDday), respectively. For the extreme precipitations in the category 1, the abrupt change point from less to more values occurs in 1991 in summer. Three abrupt change points, from less to more in 1972 and 2009, and from more to less in 1994 occur in spring. For the extreme precipitations in the category 2, the abrupt change point from less to more values occurs in 1993 in summer. Three abrupt change points, from less to more in 1965 and 2010, and from more to less in 1990 occur in spring. Annually and seasonally, the abrupt changes occur in early 2010s for CWDday which has clearly been more and for CDDday which has clearly been less. In addition, CWDday occurs abrupt change points from less to more in 1966 and from more to less in1983 in spring. The variations of these extreme precipitations have significant periodic oscillations of 3–5 years, quasi-8 years or 8–14 years. During 1961–1994, 1995–2009 and 2010–2018 three stages, the changes of the annual and most seasonal R95P, R99P, R10day, R20day and SDII are consistent with those of precipitation. The values in the latter stage are increasing compared with those in the former stage. The changes of RX1day, RX5day, CWDday and CDDday have their own characteristics.
R-spondin 3 deletion favors Erk phosphorylation to enhance Wnt signaling and bone formation
Authors: Nagano Kenichi , Yamana Kei , Saito Hiroaki , Kiviranta Riku , Pedroni Ana Clara , Raval Dhairya , Niehrs Christof , Gori Francesca , Baron Roland 
Published: September 2021

Abstract
Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly associated with bone density, but how RSPO3 affects skeletal homeostasis is not fully understood. Here we show that in mice Rspo3 haplo-insufficiency or its targeted deletion in osteoprogenitors lead to an increase in bone formation and bone mass. Contrary to expectations, Rspo3 haplo-insufficiency results in canonical Wnt signaling activation. Using mouse embryonic fibroblasts we show that Rspo3 deficiency leads to activation of Erk signaling, stabilizing β-catenin. Furthermore, Rspo3 haplo-insufficiency impairs Dkk1 efficacy in blocking canonical Wnt signaling and prevents the in vivo inhibition of bone formation and bone mass induced by osteoblast-targeted expression of Dkk1. We conclude that Rspo3 haplo-insufficiency/deficiency boosts canonical Wnt signaling by activating Erk signaling and impairing Dkk1’s inhibitory activity, which in turn lead to increased bone formation and bone mass.