bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Outcomes of Microfracture for Treatment of Osteochondral Lesions of the Talus
Authors: Corr Daniel , Raikin Jared , O’Neil Joseph , Raikin Steven 
Published: March 2021

Background: Microfracture is the most common reparative surgery for osteochondral lesions of the talus (OLTs). While shown to be effective in short- to midterm outcomes, the fibrocartilage that microfracture produces is both biomechanically and biologically inferior to that of native hyaline cartilage and is susceptible to possible deterioration over time following repair. With orthobiologics being proposed to augment repair, there exists a clear gap in the study of long-term clinical outcomes of microfracture to determine if this added expense is necessary. Methods: A retrospective review of patients undergoing microfracture of an OLT with a single fellowship-trained orthopedic surgeon from 2007 to 2009 was performed. Patients meeting the inclusion criteria were contacted to complete the Foot and Ankle Ability Measure (FAAM) Activities of Daily Living (ADL) and Sports subscales and visual analog scale (VAS) for pain, as well as surveyed regarding their satisfaction with the outcome of the procedure and their likelihood to recommend the procedure to a friend with the same problem using 5-point Likert scales. Patient demographics were reviewed and included for statistical analysis. Results: Of 45 respondents, 3 patients required additional surgery on their ankle for the osteochondral defect, yielding a 10-year survival rate of 93.3%. Of surviving cases, 90.4% (38/42) reported being “extremely satisfied” or “satisfied” with the outcome of the procedure. The VAS score at follow-up averaged 14 out of 100 (range, 0-75), while the FAAM-ADL and FAAM-Sports scores averaged 90.29 out of 100 and 82 out of 100, respectively. Thirty-six patients (85.7%) stated that their ankle did not prevent them from participating in the sports of their choice. Conclusion: The current study represents a minimum 10-year follow-up of patients undergoing isolated arthroscopic microfracture for talar osteochondral defects, with a 93.3% survival rate and 85.7% return to sport. While biological adjuvants may play a role in improving the long-term outcomes of microfracture procedures, larger and longer-term follow-up studies are required for procedures using orthobiologics before their cost can be justified for routine use. Level of Evidence: Level IV, retrospective cohort case series study.
Photodynamic therapy for macular choroidal osteoma
Authors: Scupola Andrea , Ruggeri Maria Ludovica , Sammarco Maria Grazia , Pagliara Monica Maria , Blasi Maria Antonietta 
Published: March 2021

Purpose: To report a case of macular choroidal osteoma treated with photodynamic therapy. Observations: A 34-years old woman with decreased visual acuity in her left eye came to our observation for assessment of an amelanotic choroidal tumor in the left eye. On the basis of ophthalmoscopic and echographic features the tumor was diagnosed as choroidal osteoma. Imaging examination revealed subretinal fluid involving the foveal area associated with alterations of outer neuroepithelial layers and photoreceptors without evidence of choroidal neovascularization. Foveal sparing standard fluence rate photodynamic therapy was performed. After treatment, subretinal fluid reabsorption and visual acuity recovery was noted with progressive restoration of foveal architecture. Due to the relapse of fluid and visual impairment, 1 year after treatment, a second PDT session was made using the same parameters and protocol of treatment. Despite a complete subretinal fluid reabsorption and visual acuity recovery the second treatment was complicated by the development of subretinal fibrosis. Conclusions: PDT is effective to induce subretinal fluid reabsorption and visual recovery in choroidal osteoma located in the macular area. However, the risk of possible complications related to the treatment have to be considered.
Treaties and re-setting the colonial relationship: Lessons for Australia from the Treaty of Waitangi
Authors: O'Sullivan Dominic 
Published: March 2021

Colonial hegemony distinguishes relationships between the Australian state and Indigenous nations. British government was violently established and there was no accommodation with the Indigenous populations to allow settlement to proceed, as occurred through treaties in Canada and New Zealand. Indigenous arguments for treaties in Australia are, however, well established. Notwithstanding some Commonwealth and state and territory governments considering such agreements over the past 40 years, none have been concluded, and more modest forms of recognition have been alternatively proposed. In 2015, following extensive Indigenous advocacy, the Prime Minister and Leader of the Opposition appointed a Referendum Council to consult on an amendment to the Commonwealth Constitution to recognise Australia’s first peoples. The recommendation of a Voice to Parliament and a Makarrata Commission to oversee truth telling and agreements to allow ‘coming together after a struggle’ suggested a transformative ambition beyond the Prime Minister and Leader of the Opposition’s expectations. Makarrata does not stipulate treaties as an ideal form of agreement, but in raising the possibility, the Council added to the concept’s political momentum. This article discusses the place of treaties in contemporary Australian discourse, including treaty negotiations that are in progress in Victoria, Queensland and the Northern Territory. It uses examples from New Zealand’s Treaty of Waitangi to discuss their possibilities and limits in Australia. From these examples, two overarching arguments are made. Firstly, that treaties are potentially transformative, not because they may settle historical grievances, but because their required mutual recognition of each party’s enduring political standing means that they define ongoing, just terms of association. Secondly, the substantively different political arrangements that they presume mean that they are not merely instruments of egalitarian justice and are instead concerned with the distribution of political authority – Indigenous authority over their affairs and through a distinctive and culturally contextualised state citizenship.
Severe and critical COVID-19 in pregnancy: A case series from Montreal
Authors: Trahan Marie-Julie , Malhamé Isabelle , Mitric Cristina , Simard Camille , Lipes Jed , Abenhaim Haim A 
Published: March 2021

Background Optimal obstetric management for women with coronavirus disease (COVID-19) is not known. We describe the management of six pregnant women requiring in-hospital care for severe COVID-19. Methods A retrospective chart review was conducted to identify pregnant women who tested positive for Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) between 15 March and 30 June 2020. A subset of women meeting criteria for severe COVID-19 was included. Results Four women required non-invasive supplemental oxygen therapy and two required mechanical ventilation. Four women were discharged from hospital undelivered and two required preterm delivery. One woman had a pulmonary embolism, and two required re-admission for worsening symptoms. Conclusion Management of pregnant women with severe COVID-19 is complex and should involve multidisciplinary expertise. Avoiding early delivery may be a safe option. We recommend an individualized approach to care, including careful consideration of the expected risks and benefits of expectant obstetric management versus delivery.
L-Shaped Arthroscopic Posterior Capsular Release in Frozen Shoulder
Authors: Morsy Mohamed Gamal , Waly Ahmed Hassan , Ashraf Galal Mostafa , Ayman El Hussein Mohamed , Gawish Hisham Mohamed 
Published: March 2021

Background: The inadequate arthroscopic release of the tight posterior capsule in frozen shoulder may result in limited postoperative shoulder internal rotation. Indication: The purpose of this article is to describe an L-shaped arthroscopic posterior capsular release to overcome the limited internal rotation that may be encountered following the standard longitudinal technique. Operative intervention is indicated in patients with refractory shoulder stiffness with limitation of internal rotation of grade 0, +2, +4 (according to the Constant-Murley Score), after failure of conservative measures for 3 to 6 months. The technique is contraindicated if less than 3 months of physical therapy, shoulder stiffness due to osseous deformity, infection, or cuff tear arthropathy. Technique: After performing a standard anterior capsular release, the scope is shifted to the anterior portal to perform posterior capsular release by introducing the radiofrequency ablation device through the posterior portal. Posterior release begins from the glenoid level down to the 6 o’clock position until the back fibers of the infraspinatus muscle appear. Then the hook-tip part of the radiofrequency ablation device is used to perform a transverse release in the posterior capsule, starting from the beginning of the longitudinal limb. The transverse limb is performed in a stepwise manner going step-by-step laterally but ending before reaching the rotator cuff to avoid any damage of the cuff. After that, the shoulder was manipulated according to Codman technique. Results: A comparative study was performed on 43 patients with primary frozen shoulder to compare the standard longitudinal (22 patients) and L-shaped (21 patients) posterior capsular release. At the final follow-up, there was a statistically significant improvement in the internal rotation range of motion in the L-shaped group ( P < .001). There was no loss of function over time. Moreover, there were no infections, instability, or axillary nerve injury in either group. Discussion/Conclusion: Restriction of internal rotation in frozen shoulder has been attributed to posterior capsular tightness. The L-shaped arthroscopic posterior capsular release in patients with primary frozen shoulder significantly improves the postoperative internal rotation range of motion.
Post-COVID-19 travel behaviour patterns: impact on the willingness to pay of users of public transport and shared mobility services in Spain
Authors: Awad-Núñez Samir , Julio Raky , Gomez Juan , Moya-Gómez Borja , González Julián Sastre 
Published: March 2021

Abstract
Background
The COVID-19 crisis has meant a significant change in the lifestyle of millions of people worldwide. With a lockdown that lasted almost three months and an impulse to new normality, transport demand has suffered a considerable impact in the Spanish case. It is mandatory to explore the effect of the pandemic on changes in travel behaviour in post-COVID-19 times.

Methodology
A nationwide survey was carried out during the lockdown in Spring 2020 to overview the recent changes. The survey collected both stated preferences (socio-demographic characteristics and mobility-related attributes), and revealed preferences (individuals’ habits, especially in the frequency of the trips according to the trip purpose, and opinions regarding the willingness and acceptability of these changes, and which actors would have to drive them, and how) of individuals. This paper aims to study and understand the willingness to adopt a set of measures to improve the safety conditions of public transport and shared mobility services against possible contagion from COVID-19 and the willingness to pay for them.

Results
The results obtained show that some measures, such as the increase of supply and vehicle disinfection, result in a greater willingness to use public transport in post-COVID-19 times. Similarly, the provision of covers for handlebars and steering wheels also significantly increases individuals’ willingness to use sharing services. However, respondents expect that these measures and improvements would be implemented but maintaining the same pre-COVID-19 prices. The results of this research might help operators deploy strategies to adopt their services and retain users.
Can reference points explain wage rigidity? Experimental evidence
Authors: Koch Christian 
Published: March 2021

AbstractI examine whether reference points can provide an explanation for rigid wages in recessions. Even though a recession provides a good reason to adjust wages downward, workers’ perception of a “fair wage” may depend on their previous wage, their reference point. Using a laboratory experiment, I test this idea by varying whether initially concluded contracts—and their stipulated wages—can serve as reference points. My experimental results show that with initial contracts workers punish wage cuts even in recessions, leading to considerable more rigid wages. Surprisingly, this is even true without an “objective” justification to feel entitled to initial contracts.
Integrative genomic expression analysis reveals stable differences between lung cancer and systemic sclerosis
Authors: Li Heng , Ding Liping , Hong Xiaoping , Chen Yulan , Liao Rui , Wang Tingting , Meng Shuhui , Jiang Zhenyou , Liu Dongzhou 
Published: March 2021

AbstractBackgroundThe incidence and mortality of lung cancer are the highest among all cancers. Patients with systemic sclerosis show a four-fold greater risk of lung cancer than the general population. However, the underlying mechanism remains poorly understood.MethodsThe expression profiles of 355 peripheral blood samples were integratedly analyzed, including 70 cases of lung cancer, 61 cases of systemic sclerosis, and 224 healthy controls. After data normalization and cleaning, differentially expressed genes (DEGs) between disease and control were obtained and deeply analyzed by bioinformatics methods. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed online by DAVID and KOBAS. The protein–protein interaction (PPI) networks were constructed from the STRING database.ResultsFrom a total of 14,191 human genes, 299 and 1644 genes were identified as DEGs in systemic sclerosis and lung cancer, respectively. Among them, 64 DEGs were overlapping, including 36 co-upregulated, 10 co-downregulated, and 18 counter-regulated DEGs. Functional and enrichment analysis showed that the two diseases had common changes in immune-related genes. The expression of innate immune response and response to virus-related genes increased significantly, while the expression of negative regulation of cell cycle-related genes decreased notably. In contrast, the expression of mitophagy regulation, chromatin binding and fatty acid metabolism-related genes showed distinct trends.ConclusionsStable differences and similarities between systemic sclerosis and lung cancer were revealed. In peripheral blood, enhanced innate immunity and weakened negative regulation of cell cycle may be the common mechanisms of the two diseases, which may be associated with the high risk of lung cancer in systemic sclerosis patients. On the other hand, the counter-regulated DEGs can be used as novelbiomarkers of pulmonary diseases. In addition, fat metabolism-related DEGs were consideredto be associated with clinical blood lipid data.
The resilience scale: factorial structure, reliability, validity, and parenting-related factors among disaster-exposed adolescents
Authors: Shi Xuliang , Wang Shuo , Wang Zhen , Fan Fang 
Published: March 2021

Abstract
Background
In this study, we examined psychometric properties of the Chinese version of the Resilience Scale (RS) and parenting-related factors associated with resilience among disaster-exposed adolescents.

Methods
Eighteen months after the earthquake, a total of 1266 adolescents (43.4% male, mean age = 15.98; SD = 1.28) were assessed using the RS, the Post-traumatic Stress Disorder Self-Rating Scale, the Depression Self-rating Scale for Children, the Screen for Child Anxiety Related Emotional Disorders, and Parental Bonding Instrument.

Results
Through exploratory factor analyses (EFAs) and parallel analysis, responses were characterized into a 3-factor structure: personal competence, meaningfulness, and acceptance of self and life. Cronbach’s alpha coefficient for the RS was 0.89 and the test-retest reliability coefficient was 0.72. In terms of predictive validity, resilience was found to be a significant predictor for PTSD, depression, and anxiety. Multiple regression analysis showed that maternal parenting styles were significant predictors of resilience after adjusting for gender, age, sibling number, and earthquake experiences.

Conclusions
The Chinese version of RS is a reliable and valid tool for assessing resilience among adolescent survivors after disasters. The implications for research and resilience-oriented interventions were also discussed.
Genetic diversity and antifungal susceptibility of Candida albicans isolates from Iranian HIV-infected patients with oral candidiasis
Authors: Tamai Iradj Ashrafi , Pakbin Babak , Fasaei Bahar Nayeri 
Published: March 2021

AbstractObjectiveThe objectives of this study were to investigate the antifungal susceptibility and genetic diversity ofCandida albicansisolated from HIV+patients with oropharyngeal candidiasis. A total of 50C. albicansisolates were cultured on Sabouraud glucose agar containing chloramophenicol. The antifungal susceptibility of the isolates against fluconazole, clotrimazole, nystatin, amphotericin B, ketoconazole and flucytosine was assessed using disc diffusion method. The genetic diversity ofC. albicansisolates was determined using random amplified polymorphic DNA marker.ResultsThe inhibition zones ranged from 4 ± 1.8 to 40 ± 3.8 mm for fluconazole, 7 ± 1.0 to 37 ± 1.8 mm for ketoconazole, 14 ± 0.8 to24 ± 0.8 mm for amphotericin B, 25 ± 0.0 to 33 ± 0.0 mm for nystatin and 7 ± 4.2 to 40 ± 0.0 mm for clotrimazole. At 90% similarity, three distinct groups were observed. The smallest cluster composed of 3 isolates, whereas the largest one composed of 17 isolates. 32% (16/50), 28% (14/50) and 14% (7/50) were resistant to fluconazole, ketoconazole and clotrimazole, respectively.
Migration of pre-induced human peripheral blood mononuclear cells from the transplanted to contralateral eye in mice
Authors: Huang Jianfa , Xian Bikun , Peng Yuting , Zeng Baozhu , Li Weihua , Li Zhiquan , Xie Yaojue , Zhao Minglei , Zhang Hening , Zhou Minyi , Yu Huan , Wu Peixin , Liu Xing , Huang Bing 
Published: March 2021

AbstractBackgroundRetina diseases may lead to blindness as they often afflict both eyes. Stem cell transplantation into the affected eye(s) is a promising therapeutic strategy for certain retinal diseases. Human peripheral blood mononuclear cells (hPBMCs) are a good source of stem cells, but it is unclear whether pre-induced hPBMCs can migrate from the injected eye to the contralateral eye for bilateral treatment. We examine the possibility of bilateral cell transplantation from unilateral cell injection.MethodsOne hundred and sixty-one 3-month-old retinal degeneration 1 (rd1) mice were divided randomly into 3 groups: an untreated group (n = 45), a control group receiving serum-free Dulbecco’s modified Eagle’s medium (DMEM) injection into the right subretina (n = 45), and a treatment group receiving injection of pre-induced hPBMCs into the right subretina (n = 71). Both eyes were examined by full-field electroretinogram (ERG), immunofluorescence, flow cytometry, and quantitative real-time polymerase chain reaction (qRT-PCR) at 1 and 3 months post-injection.ResultsAt both 1 and 3 months post-injection, labeled pre-induced hPBMCs were observed in the retinal inner nuclear layer of the contralateral (left untreated) eye as well as the treated eye as evidenced by immunofluorescence staining for a human antigen. Flow cytometry of fluorescently label cells and qRT-PCR of hPBMCs genes confirmed that transplanted hPBMCs migrated from the treated to the contralateral untreated eye and remained viable for up to 3 months. Further, full-field ERG showed clear light-evoked a and b waves in both treated and untreated eyes at 3 months post-transplantation. Labeled pre-induced hPBMCs were also observed in the contralateral optic nerve but not in the blood circulation, suggesting migration via the optic chiasm.ConclusionIt may be possible to treat binocular eye diseases by unilateral stem cell injection.Graphical abstract
mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
Authors: Li Yi , Xu Yujun , Liu Xinghan , Yan Xin , Lin Yue , Tan Qian , Hou Yayi 
Published: March 2021

Abstract
Background
Skin wounds in diabetic patients hardly recover. Accumulating evidence has shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived suppressor cells (MDSCs) are involved in inflammatory-related response. INK128 is a novel mTOR kinase inhibitor in clinical development. However, the exact roles of MDSCs and INK128 in healing wound of diabetic patients are unclear.

Methods
Mice models of normal, diabetic, and diabetic+INK128 were constructed. Bone marrow (BM)-derived macrophages and RAW264.7 cell line co-cultured with MDSCs, which were induced at different conditions. Flow cytometry, western blot, quantitative real-time PCR, and immunohistochemical analysis were performed.

Results
Diabetic mice (DM) had a slower recovery rate, thinner epidermis and dermis, and less blood vessels than those of normal mice. MDSCs were abnormally accumulated in DM, mTOR was activated in MDSCs of DM, and the cells were treated with high glucose. Moreover, mTOR signaling inhibitor INK128 could promote wound healing through reducing the MDSCs. MDSC function was disordered in DM and high-glucose environments, while INK128 could help retrieve their function. Furthermore, high glucose and other factors in DM could promote M-MDSC differentiation to M1 pro-inflammatory macrophage cells, thus inhibiting wound healing. The differentiation, which was dependent on mTOR signaling, could be reversed by INK128.

Conclusion
INK128 is potential to be developed as a clinical strategy to promote wound healing of diabetic patients.
Sex differences in fetal Doppler parameters during gestation
Authors: Jagota Dakshita , George Hannah , Walker Melissa , Ravi Chandran Anjana , Milligan Natasha , Shinar Shiri , Whitehead Clare L. , Hobson Sebastian R. , Serghides Lena , Parks W. Tony , Baschat Ahmet A. , Macgowan Christopher K. , Sled John G. , Kingdom John C. , Cahill Lindsay S. 
Published: March 2021

Abstract
Background
Fetal sex is known to affect pregnancy outcomes. In current clinical practice, monitoring of fetal well-being is based on Doppler ultrasound measurements of major placental and fetal vessels. The objective of this study was to investigate the effect of fetal sex on Doppler parameters throughout gestation in healthy pregnancy.

Methods
A prospective study was conducted in 240 pregnant women with ultrasound examinations at a 4-weekly interval between 12 and 38 weeks of gestation. Pulsed Doppler spectra were collected for the umbilical arteries (UAs), middle cerebral artery (MCA), descending abdominal aorta (DAo), and ductus venosus (DV). Linear mixed effects models were used to determine if the pulsatility indices (PIs) of these vessels depended on gestational age and fetal sex.

Results
While there were no differences in the MCA PI and DV PIV over gestation between female and male fetuses, the trajectory of the UA and DAo PIs differed by fetal sex (p = 0.02 and p = 0.01, respectively).

Conclusions
Doppler ultrasound parameters were found to be dependent on fetal sex for some vessels and not for others in healthy pregnancies. Further investigations are needed to understand the physiological mechanisms for these sex differences and the relevance for disease processes in pregnancy.