bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway
Authors: Zhang Lili , Qu Sihao , Wang Lu , Wang Chunguo , Yu Qinghe , Zhang Zhimin , Diao Yirui , Zhang Binbin , Li Yadong , Shi Yuanyuan , Wang Peng 
Published: April 2021

Background: Pulmonary Fibrosis (PF) is an interstitial lung disease characterized by excessive accumulation of extracellular matrix in the lungs, which disrupts the structure and gas exchange of the alveoli. There are only two approved therapies for PF, nintedanib (Nib) and pirfenidone. Therefore, the use of Chinese medicine for PF is attracting attention. Tianlongkechuanling (TL) is an effective Chinese formula that has been applied clinically to alleviate PF, which can enhance lung function and quality of life.Purpose: The potential effects and specific mechanisms of TL have not been fully explored, yet. In the present study, proteomics was performed to explore the therapeutic protein targets of TL on Bleomycin (BLM)-induced Pulmonary Fibrosis.Method: BLM-induced PF mice models were established. Hematoxylineosin staining and Masson staining were used to analyze histopathological changes and collagen deposition. To screen the differential proteins expression between the Control, BLM, BLM + TL and BLM + Nib (BLM + nintedanib) groups, quantitative proteomics was performed using tandem mass tag (TMT) labeling with nanoLC-MS/MS [nano liquid chromatographymass spectrometry]). Changes in the profiles of the expressed proteins were analyzed using the bioinformatics tools Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). The protein–protein interactions (PPI) were established by STRING. Expressions of α-smooth muscle actin (α-SMA), Collagen I (Col1a1), Fibronectin (Fn1) and enzymes in arginase-ornithine pathway were detected by Western blot or RT-PCR.Result: TL treatments significantly ameliorated BLM-induced collagen deposition in lung tissues. Moreover, TL can inhibit the protein expressions of α-SMA and the mRNA expressions of Col1a1 and Fn1. Using TMT technology, we observed 253 differentially expressed proteins related to PPI networks and involved different KEGG pathways. Arginase-ornithine pathway is highly significant. The expression of arginase1 (Arg1), carbamoyltransferase (OTC), carbamoy-phosphate synthase (CPS1), argininosuccinate synthase (ASS1), ornithine aminotransferase (OAT) argininosuccinate lyase (ASL) and inducible nitric oxide synthase (iNOS) was significantly decreased after TL treatments.Conclusion: Administration of TL in BLM-induced mice resulted in decreasing pulmonary fibrosis. Our findings propose that the down regulation of arginase-ornithine pathway expression with the reduction of arginase biosynthesis is a central mechanism and potential treatment for pulmonary fibrosis with the prevention of TL.
Beneficial Effect of Lenalidomide-Dexamethason Treatment in Relapsed/Refractory Multiple Myeloma Patients: Results of Real-Life Data From 11 Hungarian Centers
Authors: Varga Gergely , Dávid Tóth András , Réka Szita Virág , Csukly Zoltán , Hardi Apor , Gaál-Weisinger Júlia , Nagy Zsolt , Altai Elvira , Rencsik Annamária , Plander Márk , Szendrei Tamás , Kórád Krisztina , Radványi Gáspár , Rottek János , Deák Beáta , Szaleczky Erika , Schneider Tamás , Kohl Zoltán , Kosztolányi Szabolcs , Alizadeh Hussain , Lengyel Zsuzsanna , Modok Szabolcs , Borbényi Zita , Lovas Szilvia , Váróczy László , Illés Árpád , Rajnics Péter , Masszi Tamás , Mikala Gábor 
Published: April 2021

In Hungary, the cost of lenalidomide-based therapy is covered only for relapsed multiple myeloma (MM) patients, therefore lenalidomide is typically used in the second-line either as part of a triplet with proteasome inhibitors or as a doublet. Lenalidomide-dexamethasone is a standard treatment approach for relapsed/refractory MM, and according to recent large randomized clinical trials (RCT, the standard arm of POLLUX, ASPIRE, TOURMALINE), the progression-free survival (PFS) is expected to be approximately 18 months. We surveyed ten Hungarian centers treating MM and collected data of 278 patients treated predominantly after 2016. The median age was 65 years, and patients were distributed roughly equally over the 3 international staging system groups, but patients with high risk cytogenetics were underrepresented. 15.8% of the patients reached complete response, 21.6% very good partial response, 40.6% partial response, 10.8% stable disease, and 2.5% progressed on treatment. The median PFS was unexpectedly long, 24 months, however only 9 months in those with high risk cytogenetics. We found interesting differences between centers regarding corticosteroid type (prednisolone, methylprednisolone or dexamethasone) and dosing, and also regarding the choice of anticoagulation, but the outcome of the various centers were not different. Although the higher equivalent steroid dose resulted in more complete responses, the median PFS of those having lower corticosteroid dose and methylprednisolone were not inferior compared to the ones with higher dose dexamethasone. On multivariate analysis high risk cytogenetics and the number of prior lines remained significant independent prognostic factors regarding PFS (p &lt; 0.001 and p = 0.005). Our results show that in well-selected patients Lenalidomide-dexamethasone can be a very effective treatment with real-world results that may even outperform those reported in the recent RCTs. This real world information may be more valuable than outdated RCT data when treatment options are discussed with patients.
Estrategia metodológica para el aprendizaje de la lectura comprensiva
Authors: Mendoza Machado Judith Marlene 
Published: April 2021

El presente artículo da cuenta de los resultados hallados en el estudio realizado respecto a las limitaciones que presentan en el proceso de aprendizaje de la lectura comprensiva los estudiantes de 4º y 5º grado del nivel primario de la Unidad Educativa “Beatriz Hartmann de Bedregal”, quienes en las primeras pesquisas realizadas previas a la investigación mostraron una lectura lineal y silábica correspondiente al primer nivel de comprensión, se muestra los resultados de la aplicación de diferentes métodos con sus respectivos instrumentos, elaborados a partir de indicadores relacionados con elementos que tienen que ver con las dimensiones afectivo, metodológico, meta-cognitivo, semántico conceptual, resultados que confirmaron la existencia del problema identificado inicialmente. Describe la propuesta expresada en la estrategia metodológica como una respuesta a la problemática identificada inicialmente y tiene el propósito de potenciar el aprendizaje de esa habilidad además de ofrecer una guía de lectura a partir de una selección de variedad de textos con acciones concretas aplicadas antes, durante y después del proceso lector, pero principalmente sobre la base de los niveles de comprensión, elemento base de la temática de estudio.
Accelerated ferroelectric phase transformation in HfO2/ZrO2 nanolaminates
Authors: Migita Shinji , Ota Hiroyuki , Asanuma Shutaro , Morita Yukinori , Toriumi Akira 
Published: April 2021

Abstract
Ferroelectric phase transformation was compared between the Hf0.5Zr0.5O2 solid solution films and the HfO2/ZrO2 nanolaminate films, prepared by sputter deposition without heat treatment and crystallized by following cap annealing. Physical analyses showed that nanolaminate structures and their interfaces were robust even after high-temperature annealing. Ferroelectricity appeared largely in the nanolaminate films than in the solid solution film, and the best performance was attained in the nanolaminate film with the cycle thickness of monolayer oxide (0.25 nm). Long period annealing cleared that the ferroelectric phase transformation is greatly accelerated in the nanolaminate films than in the solid solution films.
Anesthesiologists’ occupational wellbeing and support during COVID-19 pandemic
Authors: Khan Fauzia A. 
Published: April 2021

Anesthesiologists have been at the forefront of COVID-19 pandemic and are particularly at risk of suffering both physical and emotional effects. There have been several individual and organizational strategies that can be put in place to tackle their well-being. Self-strategies that are recommended are adequate rest and sleep, consistent work breaks, help seeking behavior, emotional control and acceptance of limitations of their own competence and healthcare systems. Several online training programs are available for individual guidance. Organizations can also support their staff in different ways. It is important to recognize those who are more vulnerable physically and emotionally. Institution should implement stress reduction strategies, provide adequate PPE, should be able to communicate with their employees in a clear and honest manner and enforce infection control policies. In addition, institutions must take other physical measures where resources permit, like provision of negative pressure rooms and to provide updated and accurate information. Both personal and psychological support is needed. Several different models have been suggested for emotional support. One particularly vulnerable group that requires additional assistance are those in quarantine. Last but not least, in addition to the implementation of all these measures it is imperative to sustain these activities.
Key words: Anesthesiology; Anesthesiologists; COVID-19; Stress, Psychological
Citation: Khan FA. Anesthesiologists’ occupational wellbeing and support during COVID-19 pandemic. Anaesth. pain intensive care 2021;25(2):122-125. DOI: 10.35975/apic.v25i2.1459
Received: 21 February 2021, Accepted: 25 February 2021
Premedication with gabapentin for laryngoscopy: a double-blind randomized control trial in hypertensive patients
Authors: Riasat Muhammad Imran , Chohan Haris Tariq , Kumar Arun , Sultan Syed Farjad , Javaid Hanya , Siddiqui Safia Zafar 
Published: April 2021

Background & Objective: Laryngoscopy and intubation (L&I) are strong stimulus for cardiovascular system. Hypertensive patients have a greater incidence of coexisting coronary artery disease and cerebrovascular insufficiency. Several methods have been in practice to prevent or alter the hemodynamic response to L&I. Although the main use of gabapentin has been as an antiepileptic, but its effect on the hemodynamic reflexes is still under evaluation. We compared the effectiveness of a single dose of gabapentin 800 mg on the mean arterial pressure (MAP) in response to L&I in hypertensive patients undergoing day care surgery.
Methodology: This randomized, control trial was conducted in operating rooms, Dr Ruth K M Pfau Civil Hospital Karachi, from May 2017 to November 2017. A total of 150 patients undergoing elective surgery requiring general anesthesia with tracheal intubation were included in this study. Patients were randomly allocated equally into two group; Group G (gabapentin group) and Group P (placebo group). Patients in Group G received gabapentin 800 mg and Group P received placebo, 2 h prior to induction of anesthesia. MAP was measured at baseline (before induction), before intubation (after induction), at time 0 (immediately after intubation), and at 1 min, 3 min, 5 min, and 10 min after intubation. Effectiveness was defined as all the MAP reading to be within 30% of the baseline reading.
Results: There were 72(48%) males and 78(52%) females. Effectiveness was significantly higher in patients of Group G, as compared to placebo group (Group P) [94.7% vs. 65.3%; p = 0.0005].
Conclusion: Gabapentin effectively suppresses the increase in MAP in response to laryngoscopy and tracheal intubation as compared to the placebo.
Abbreviations: L&I: Laryngoscopy and intubation; MAP: Mean arterial pressure; ECG: Electrocardiography; ASA: American Society of Anesthesiologists; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure
Key words: Laryngoscopy; Intubation; Hypertension; Gabapentin; Stress response
Citation: Riasat MI, Chohan HT, Kumar A, Sultan SF, Javaid H, Siddiqui SZ. Premedication with gabapentin for laryngoscopy: a double-blind randomized control trial in hypertensive patients. Anaesth. pain intensive care 2021;25(2):163-169. DOI: 10.35975/apic.v25i2.1464
Assessment of perceived stress among resident trainees of a tertiary care hospital in Saudi Arabia during COVID–19 pandemic – a cross-sectional study
Authors: Ul Huda Anwar , Yasir Mohammad , Saulat Swaid Raza , AlShaqha Mohammad Waleed 
Published: April 2021

Background & Objective: The massive burden of COVID-19 disease is believed to be associated with significant psychological disturbances on healthcare professionals. Increasing levels of stress may lead to anxiety, depression, burnout syndrome, and in severe cases, post-traumatic stress disorder. The objective of this study was to examine the presence of stress among resident trainee doctors working in a tertiary care hospital in Saudi Arabia in the context of the corona pandemic.
Methodology: This was a cross-sectional study conducted in Security Forces Hospital, Riyadh, Saudi Arabia. We included the resident trainee doctors from different specialties of our hospital including medical, surgical, anesthesia, emergency room (ER), and critical care units. We used convenience sampling to select study respondents. Perceived Stress Scale (PSS) was used for assessing the stress levels among trainees. Trainees were requested to fill the questionnaire either online survey monkey or in paper form. All data were entered and analyzed using SPSS version 26. We calculated mean, standard deviation, frequency count, and percentages for the perceived stress.
Results: A total of 60 trainees were included in this study. Mean PSS-10 score was 20 ± 5.51, with a range between 6 and 34. Four (6.7 %) trainees had low stress and 50 (83.3 %) trainees had moderate stress while 6 (10 %) trainees had high stress
Conclusion: The majority of resident trainees in our study experienced a moderate level of anxiety during this COVID pandemic.
Key words: Stress, Resident trainees, COVID-19, pandemic
Citation: ul Huda A, Yasir M, Saulat SA, AlShaqha MW. Assessment of perceived stress among resident trainees of a tertiary care hospital in Saudi Arabia during COVID–19 pandemic – a cross-sectional study. Anaesth. pain intensive care 2021;25(2):185-188. DOI: 10.35975/apic.v25i2.1471
High flow nasal cannula to prevent intubation in obese patient with COVID-19 induced ARDS: a case report
Authors: Mariati Ni Made Ayu Suria , Sugiarto Adhrie , Endriani Elya , Lestari Rina , Anindita Karina 
Published: April 2021

Obese patients have been identified to have a poor prognosis and a higher risk of death from coronavirus disease-2019 (COVID-19). We present reports of two obese patients infected with COVID-19 with acute respiratory distress syndrome (ARDS) who showed improvement with high flow nasal cannula (HFNC). HFNC is a noninvasive oxygen delivery device which is capable of delivering a high concentration of oxygen that can reduce the requirement for tracheal intubation. HFNC is convenient to use, can reduce dyspnea without effecting the length of stay in ICU in these cases; and has a high merit to be used in selected patients requiring oxygen before attempting intubation and mechanical ventilation.
Key words: ARDS; COVID-19; High flow nasal cannula; HFNC; Obese
Citation: Mariati NMAS, Sugiarto A, Endriani E, Lestari R, Anindita K. High flow nasal cannula to prevent intubation in obese patient with COVID-19 induced ARDS: a case report. Anaesth pain intensive care 2021;25(2):212-216. DOI: 10.35975/apic.v25i2.1473
Received: 18 November 2020, Reviewed: 24 November 2020, Accepted: 7 December 2020
Pathogenesis and management of pain in amyotrophic lateral sclerosis
Authors: Hidayati Hanik Badriyah , Pranata Celine Anindytha 
Published: April 2021

Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease is characterized by deadly progressive motor neuron disease and other neuronal cells death, which is featured by progressive paralysis and leads to advanced disability and mortality due to respiratory failure.1,2 By the year of 2040, ALS is estimated to nearly double due to global population aging.3
Pain is one of the overlooked symptom, but widely complained by patients with ALS. It can arise at any stage of the disease; and the intensity of pain may increase with the course of the disease. The pain characteristic depends upon its pathogenesis in inducing pain such as nociceptive, neuropathic, or painful cramps. Pain intensity can be severe at an advanced stage of ALS thereby increasing the use of pain relievers and sedatives. It has been related to a declined functional status leading to a decreased quality of life and escalating the rate of depression. Management in ALS patients with complaints of pain differs according to the multifactorial character of pain.4,5
The different aspects of pain in ALS has not been much discussed. Therefore, this article will provide an overview about it.
Key word: Pain; Amyotrophic lateral sclerosis; ALS; Pathogenesis; Pain management
Citation: Hidayati HB, Pranata CA. Pathogenesis and management of pain in amyotrophic lateral sclerosis. Anaesth. pain intensive care 2021;25(2):236-243. DOI: 10.35975/apic.v25i2.1478
Received: 26 November 2020, Reviewed: 27 December 2021, Accepted: 21 February 2021
Cancer, cancer pain and the ‘Cancer Pain Initiative’
Authors: Khan Tariq Hayat 
Published: April 2021

The number of cancer patients has been steadily increasing and with it the number of cancer related pain patients is also increasing. Cancer pain (CP) is the most unique and versatile pain, regarding type, intensity, site, variations and the needed management modalities. No one pain specialist or the pain center can be capable of adequately manage every cancer patient. In this background, an idea to confront this menace at a national level with a combined effort is presented. If implemented it is hoped that the CP patients will get rid of at least the worry about their excruciating pain. The idea of the ‘Cancer Pain Initiative’ has been in circulation for quite some time, but needs to be discussed at various levels.
Key words: Cancer; Cancer pain; Pain management
Citation: Khan TH. Cancer, cancer pain and the ‘Cancer Pain Initiative’. Anaesth. pain intensive care 2021;25(2):126–12. DOI: 10.35975/apic.v25i2.1482
ANALISIS KELAYAKAN USAHA DAN STRATEGI PENGEMBANGAN INDUSTRI KECIL TEMPE
Authors: Siadari Martua , Samosir Sherly Sartika J 
Published: April 2021

Industri kecil tempe di Kelurahan Tomuan menghadapi permasalahan seperti permodalan, teknologi dan akses informasi pasar. Dengan berbagai permasalahan dan kelemahan itu industri kecil tempe di Kelurahan Tomuan dapat mengalami resiko kegagalan. Penelitian ini untuk mengetahui kelayakan industri kecil tempe dan untuk mengetahui strategi pengembangan sektor industri kecil tempe di Kelurahan Tomuan Kota Pematangsiantar. Analisis kelayakan menggunakan analisis Net Present Value, Internal Rate of Return, dan Net Benefit Cost Ratio, untuk mengetahui suatu usaha layak atau tidaknya. Matriks SWOT untuk menciptakan strategi pengembangan industri kecil tempe.
Hasil penelitian menunjukkan bahwa industri kecil tempe di Kelurahan Tomuan berjumlah 18 unit usaha. Analisis Kelayakan dari industri kecil tempe di Kelurahan Tomuan Kota Pematangsiantar dengan nilai NPV adalah sebesar Rp 1.053.326.238 layak dilakukan. Nilai BCR adalah sebesar 1,49 layak dilakukan. Nilai IRR adalah sebesar 25,22%, layak dilakukan. Berdasarkan hasil analisis SWOT industri tempe di Kelurahan Tomuan mempunyai keunggulan membuat tempe menjadi tradisi, dan kelemahan dalam hal kurang memahami manajemen. Industri tempe memiliki peluang permintaan produk tinggi dan ancaman dalam banyak pesaing industri tempe lain dan tempe yang mudah busuk.
Pythium huanghuaiense sp. nov. isolated from soybean: morphology, molecular phylogeny and pathogenicity
Authors: Chen Jia-Jia , Feng Hui , Yu Jian , Ye Wenwu , Zheng Xiaobo 
Published: April 2021

Soybean (Glycine max) is a major source of edible oil and protein. A novel species of the genus Pythium, Pythium huanghuaiense, isolated from soybean seedlings in China, is described and illustrated on the basis of morphological characters and molecular evidence.
Pythium huanghuaiense sp. nov. is closely related to species of the genus Pythium in clade F, as evidenced by the presence of hyphal swellings and its relatively rapid morphological growth. However, it differs by having relatively small sporangia and plerotic or nearly plerotic and thin-walled oospores. A pathogenicity test confirmed the newly-identified species as a pathogen of soybean.
Teaching a New Approach to Quality Improvement
Authors: Green Ellie 
Published: April 2021

ABSTRACT
Whatever the educator's role in teaching quality methods, rapid, industry-wide changes in quality practices are having a profound impact on the education department Familiar, comfortable teaching methods for monitoring and evaluation have disappeared. Clinical practice models, long the mainstay of nursing education, have become obsolete in today's multidisciplined environment. This article describes a new approach to quality improvement that utilizes a model expanded beyond clinical practice: a tri-focus of patient, staff, and system, integrated with the four broad-based categories of standards (structure, outcome, process, and evaluation) to achieve quality improvement within the organization.
Generic Orientation for Agency Nurses
Authors: Bliss Julie Beshore , Alsdort Phyllis 
Published: April 2021

ABSTRACT
The nurse shortage in hospitals has brought increased entry routes to RNs. One is the employment agency. This pool of nurses has facilitated staffing, but concerned administrators struggle to meet accreditation criteria for orientation of these employees while containing costs. One method is a generic orientation program. The result is a cost savings for hospital administrators, a successful continuing education program, and an assurance of the education/training of employees hired through outside agencies.
A Collaborative Effort in Using Telecommunications to Enhance Learning
Authors: Phillips Carol Y , Hagenbuch Elaine Gallaspy , Baldwin Patricia J 
Published: April 2021

ABSTRACT
A consortium of three educational institutions was developed to respond to a possible need for educational programs in the workplace through teleconferencing technology. Based on survey findings, a pilot project of three educational programs was presented. Evaluation of the adequacy of such programming indicated its success in the use of such technology. The effort was unique because there was unprecedented collaboration among nurse executives, nurse educators, the Pennsylvania Nurses Association, the Hospital Association of Pennsylvania, and WITF, the publicly owned telecommunications center.
Nurses and Adult Educational Philosophy: A Comparison of Nurses and Non-Nurses in a Graduate Adult Education Program
Authors: Rachal John R , Pierce W Lee , Leonard Rex , DeCoux Valerie 
Published: April 2021

ABSTRACT
A sample of 90 students enrolled in a graduate program in adult education completed three instruments examining adult education philosophies during a related course. There were no significant differences between the nurse educators and the non-nurses on any of the three instruments or on any of their components. This finding contradicts previous research suggesting that nurse educators do not generally incorporate adult learning methods into their courses. Intercorrelations were computed among all the variables. One unanticipated finding was the significant relationship between age and congruence with adult learning principles.