bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA supercoiling modulates eukaryotic transcription in a gene-orientation dependent manner
Authors: Morao Ana Karina , Chervova Almira , Zhao Yuya , Ercan Sevinc , Cecere Germano 
Published: January 2025

SummaryTranscription introduces torsional stress in the DNA fiber causing it to transition from a relaxed to a supercoiled state that can propagate across several kilobases and modulate the binding and activity of DNA-associated proteins. As a result, transcription at one locus has the potential to impact nearby transcription events. In this study, we asked how DNA supercoiling affects histone modifications and transcription of neighboring genes in the multicellular eukaryoteCaenorhabditis elegans. We acutely depleted the two major topoisomerases and measured nascent transcription by Global Run-on sequencing (GRO-seq), RNA Polymerase II occupancy by ChIP-seq, gene expression by RNA-seq and four transcription-associated histone modifications by Cut & Tag. Depletion of topoisomerases I and II led to genome-wide changes in transcription dynamics, with minor disruptions to the histone modification landscape. Our results showed thatC. eleganstopoisomerase I is required for transcription elongation and is partially redundant with topoisomerase II. Analysis of transcription changes with respect to neighboring genes suggest that negative supercoiling promotes the transcription of genes with a divergent neighbor and positive supercoiling suppresses transcription of convergent genes. Additionally, topoisomerase depletion caused coordinated changes in the expression of divergent gene pairs, suggesting that negative supercoiling drives their synchronized expression. Conversely, the coordinated expression of convergent genes was disrupted, suggesting that excessive positive supercoiling inhibits transcription. Overall, our data supports a model in which DNA supercoiling generated by transcription at one site propagates along the eukaryotic chromatin fiber, influencing nearby transcription in an orientation-dependent manner.
Structural basis of directionality control in large serine integrases
Authors: Shin Heewhan , Pigli Ying , Peña Reyes Tania , Fuller James R. , Olorunniji Femi J. , Rice Phoebe A. 
Published: January 2025

AbstractLarge serine integrases (LSIs) catalyze unidirectional site-specific DNA recombination reactions, yet those reactions are reversed by the presence of a cognate recombination directionality factor (RDF). Mechanistic understanding of directionality control has been hampered by a lack of structural information. Here, we use cryo-electron microscopy (cryo-EM) to determine the structures of six SPbeta integrase—DNA complexes along the integrative (-RDF) and excisive (+RDF) reaction pathways, at 4.16-7.18Å resolution. Our findings reveal how RDF-mediated repositioning of an integrase subdomain (1) dictates which pairs of DNA sites can be assembled into a synaptic complex to initiate recombination and (2) dictates which product complexes will be conformationally locked, preventing the back reaction. These mechanistic insights provide a conceptual framework for engineering efficient and versatile genome editing tools.
Linking job crafting and self-leadership to productivity: a moderated-mediation of personal initiative, person-job fit and person-organization fit
Authors: Kidron Aviv , Rispler Clara 
Published: January 2025

PurposeThis study aimed to analyze the effect of job crafting and self-leadership on human capital productivity with the moderated-mediation effect of personal initiative as a mediator and person-job fit and person-organization fit as moderators.Design/methodology/approachAn online two-wave survey targeted 253 science, technology, engineering and mathematics (STEM) and social science graduates.FindingsThe research model was confirmed mainly in that personal initiative fully mediated the relationship between self-leadership, job crafting and perceived employee productivity. In addition, the moderated-mediation effect of the person-job fit on this relationship was partially confirmed, while that of the person-organization fit was not.Originality/valueBy interweaving the conservation of resources theory with the self-determination theory, this study’s results provide a novel theoretical justification for the dynamic process of human capital, personal resources and personal initiative as a type of intrinsic motivation. The variance between the effects of person-job fit and person-organization fit provides new insights regarding the changes in the work environment where individuals feel more connected to their careers and jobs than their organizations.
Evaluating the progress and impact of Shodhganga: enhancements, challenges and future directions for India’s centralized ETD repository
Authors: Panda Saroja Kumar , Dey Somyajeet , Bhatt Atul , Satapathy Aparna 
Published: January 2025

Purpose
This paper critically evaluates Shodhganga, India’s centralized digital repository for electronic theses and dissertations (ETDs). It explores the repository’s impact, open access policy and the roles of participating universities and the implementing agency.

Design/methodology/approach
The study uses a comprehensive analysis of Shodhganga’s features, including advancements in its user interface, participation rates and infrastructure. It reviews the repository’s progress and contributions from various institutions and compares Shodhganga with prominent international ETD repositories.

Findings
Significant enhancements have been observed in Shodhganga’s user interface and infrastructure. The repository has experienced increased contributions from universities, Centrally Funded Technical Institutes and Institutions of National Importance, with the highest number of theses submitted in 2023. Social science theses constitute a substantial portion of these submissions.

Research limitations/implications
The research underscores the necessity for improvements in Shodhganga’s software and hardware infrastructure. It offers recommendations to address identified issues and suggests technological advancements to align with modern user needs and sustainable development goals.

Originality/value
This paper provides unique insights into Shodhganga’s current challenges and offers actionable recommendations for future enhancements. It contributes to the understanding of digital repository management and its impact on academic research accessibility.
Examination of the effects of technology orientation, technology innovation strategy and strategic orientation on information technology companies in technoparks
Authors: Adiguzel Zafer , Sonmez Cakir Fatma , Karaaslan Nimet 
Published: January 2025

Purpose
The purpose of the research is to examine the effects of technology orientation (TO) on information technology companies, not as a dimension of strategic orientation (SO), but as an independent variable and together with technology innovation strategy (TIS).

Design/methodology/approach
In the research, technoparks operating in the province of Istanbul were determined as the main population. The questionnaire used was applied to the participants working in senior and middle management positions in the companies in these technoparks. Questionnaires were sent via e-mail to the participants (by random sampling method) after obtaining the necessary permissions. In total, the data of 665 participants were included in the analysis. SmartPLS program was used for analysis.

Findings
As a result of the analysis, it is supported by hypotheses that TO, TIS and SO have positive effects on performance variables.

Research limitations/implications
However, when looking at the situation that researchers should consider in terms of the limitations of the research, the data were collected only from information technology companies located in technoparks in Istanbul. Therefore, it may not be correct to make a general judgment.

Practical implications
Because future technology investments among information technology companies are important, it can be argued according to the results of the analysis that TO and technology innovation strategies are important in terms of gaining competitive advantage. At the same time, it is supported by hypotheses that SO is important to be successful in the field of technology against competitors.

Social implications
The research emphasizes how companies that are proactive in adopting and integrating new technologies can achieve superior performance results. A detailed perspective is presented on how companies can benefit from SO to maximize the return they receive from their technological investments. Additionally, focusing on technoparks as unique environments that facilitate the integration of industrial and technological resources, the research emphasizes the importance of such ecosystems in promoting innovation and economic development.

Originality/value
The research is important research that will contribute to the literature in terms of collecting and examining data from information technology companies in technoparks and examining the effects of TO and TIS of information technology companies in technoparks.
Cultivating green pioneers: examining the antecedents of sustainable entrepreneurial intent in higher education
Authors: Alimehmeti Genc , Ndoka Ervisa , Paletta Angelo 
Published: January 2025

Purpose
This study aims to explore the various factors influencing students’ intentions toward sustainable entrepreneurship by investigating the case of Albania. Specifically, among the intention antecedents, it explores the role of environmental awareness and green consumption commitment.

Design/methodology/approach
A conceptual model is created to integrate the theory of planned behavior with additional sustainability-oriented factors, providing a comprehensive examination of the factors influencing higher education students’ intentions to embark on sustainable entrepreneurial ventures. A questionnaire was designed and administered to a sample of 411 third-year bachelor students at the University of Tirana, Albania, during the 2023–2024 academic year. This study posits nine hypotheses and uses structural equation modeling to evaluate the direct and indirect effects of self-efficacy, environmental awareness, education, entrepreneurial knowledge and green consumption commitment on sustainable entrepreneurship intentions.

Findings
The findings confirm that self-efficacy, personal attitude and subjective norms directly impact students’ intentions to engage in sustainable entrepreneurial activities. In addition, the paper finds that environmental awareness influences commitment to green consumption and indirectly affects sustainable entrepreneurship intentions among students. Entrepreneurial education and knowledge have a significant indirect effect as well, highlighting the crucial role of higher education institutions in fostering an environment conducive to sustainable entrepreneurial initiatives through curriculum reorientation toward Sustainable Development Goals (SDGs) and promoting environmental stewardship.

Originality/value
This research enriches the sustainable entrepreneurship literature by shedding light on the antecedents of sustainable entrepreneurship intention among students, particularly in a developing country like Albania. It offers novel insights into the integral role of HEIs in nurturing future entrepreneurs equipped to tackle environmental challenges through innovative solutions. Furthermore, the study’s findings emphasize the importance of incorporating sustainability-focused values into educational frameworks, presenting a case for policy changes and curriculum development supporting sustainable development.
A qualitative evaluation of the social work curriculum: focusing on sustainable development and ecological justice
Authors: Akinci Merve , Yildirim Filiz , Kocak Selin , Turkoglu Bilge , Demir Busra 
Published: January 2025

Purpose
The extant social work literature reveals the need for transformation in the social work curriculum to strengthen its ecological orientation. Focusing on this orientation, this study aims to evaluate the knowledge, skills and value base of the curriculum from the perspective of social work academics in the context of sustainable development and ecological justice.

Design/methodology/approach
This qualitative case study recruited 11 participants via the criterion-based sampling method using the snowball technique. In-depth interviews were conducted for data collection. A thematic analysis of the data was conducted using MAXQDA 2022.

Findings
The findings revealed that education based on knowledge, skills and values in the human-centered work curriculum, which focuses only on the human component in the social work curriculum, is a significant obstacle to strengthening the curriculum’s ecological orientation. To achieve such an orientation, human-nature interaction should be emphasized under all three pillars, and ecological justice and sustainable development should be integrated into the social work curriculum.

Originality/value
To the best of the authors’ knowledge, this study is the first attempt in the field to focus on “ecological justice” and “sustainable development” as a way to strengthen the ecological orientation within the knowledge, skills and value base of the social work curriculum.
Moderating role of perceived justice between employee incivility and consequences of brand hate
Authors: Mushtaq Fakhra Malik , Hamzah Zalfa Laili Binti , Ghazali Ezlika Binti Mohd 
Published: January 2025

Purpose
During the past decade, marketing literature has focused on investigating the dark side of consumer emotions and their behavior. This demands further research for a more in-depth understanding. Hence, drawing on affective events theory, this study aims to examine employee incivility (rude and poor behavior) and its consequences on brand hate. Furthermore, the authors also introduced perceived justice as a moderator to buffer the impact of brand hate.

Design/methodology/approach
A scenario-based survey was used to collect data from 212 consumers from the airline industry. Structural equation modeling was performed through SmartPLS.

Findings
Findings revealed that employee incivility instigates brand hate. Results further showed that attitudinal brand hate influences brand opposition and detachment, whereas behavioral brand hate only influences brand detachment. Additionally, perceived justice moderates the negative relationship between employee incivility and brand hate. Overall, the results showed that employee incivility can trigger brand hate, and service recovery can reduce the negative impact of employee behavior on brand hate in the aviation sector.

Research limitations/implications
This study contributes to brand hate and service recovery literature.

Practical implications
This study provides deep insights into how employee behavior can cause brand hate and how recovery strategies can help buffer its impact.

Originality/value
In the existing literature, limited studies have focused on organizational factors instigating brand hate. To the best of the authors’ knowledge, this study is the first to associate employee incivility and brand hate.
Exploring postgraduate supervision barriers through interviews with early-career supervisors in the field of accountancy
Authors: Strydom Nicolaas , De Wet Milan 
Published: January 2025

PurposeThis study aims to explore the barriers to successful supervision experienced by early-career supervisors in the field of accountancy through in-depth interviews.Design/methodology/approachIn total, 13 semi-structured interviews were conducted with early-career supervisors in an accounting department at a comprehensive residential university in South Africa. The interviews were transcribed, and themes were identified through thematic analysis.FindingsFour barriers to successful supervision were identified: (1) the tension between work and research responsibilities; (2) the supervisor’s perceived lack of research skills and knowledge; (3) uncertainty about the supervision process and (4) a poorly defined student-supervisor relationship. The barriers are explored from the perspective of adult learning theory.Originality/valueEarly-career supervisors experience specific challenges in providing quality supervision. The existing literature has not adequately addressed these challenges. The study makes a novel contribution to the body of supervision literature by focusing on the challenges experienced by early-career supervisors within the field of accountancy.
Preliminary testing of a mechanism-based gait training device with able-bodied individuals
Authors: Clinton Wilson B.V. , Mohan Varma D.S. 
Published: January 2025

PurposeMillions of people throughout the world have walking disabilities. Gait training is essential for helping people with locomotor disabilities regain their ability to walk and to improve their quality of life.Design/methodology/approachThis study assesses the viability of a novel gait training device with able-bodied individuals and gauges the alterations that need to be made in the device for conducting trials with patients. It is a preliminary, single-gender, viability study with able-bodied individuals.FindingsAboutten able-bodied participants (all male, age: 28 ± 4 years old) completed the study. Almost all participants were able to complete the test. Participants undertook the training on the gait training device, and data were collected through subjective questionnaires based on safety, comfort, efficiency and satisfaction.Research limitations/implicationsThe device requires additional cushioning and support as disabled patients are heavier than able-bodied individuals. The duration of the trial is kept short and can be prolonged when comfort-related issues are addressed. Gait issues are most observed in the older population. However, the device was primarily tested on a younger population to avoid risks.Practical implicationsThe feedback from the participants will be used to make the required design changes for further clinical testing.Social implicationsOur work aims at developing a low-cost alternative for the expensive robotic gait training devices, as most clinics in the developing world are in need of affordable solutions for treating disabled patients.Originality/valueThe preliminary testing of the gait training device was successful and showed promise for further development of the device for training spinal injury and/or stroke patients.
Beyond complexity: do alms tax (zakat) law intricacies justify non-compliance behaviour?
Authors: Bin-Nashwan Saeed Awadh 
Published: January 2025

Purpose
While the foundations of alms tax (zakat) regulations remain firmly rooted in solid Islamic law (Shariah), the landscape of zakat laws has recently witnessed the emergence of nuanced issues and complexities that warrant careful consideration and scholarly investigation. Such intricacies might lead to a lack of compliance with the regulatory and legal framework many Muslim countries have implemented. Thus, this paper aims to empirically delve into the role of zakat law intricacies in compliance behaviour and how it can strengthen the impact of crucial socio-economic motivations, including perceived zakat governance and institutional credibility.

Design/methodology/approach
Drawn from a validated socio-economic model, this study used a quantitative approach, using a self-administered survey distributed among SME entrepreneurs. SmartPLS was used to yield meaningful results.

Findings
Results indicate that the more intricate the zakat law and regulations, the lower zakat compliance tends to be. However, socio-economic motivations (zakat governance and institutional credibility) positively drive the compliance behaviour of zakat payers. Interestingly, socio-economic factors lose their positive effect on zakat compliance in the face of zakat law intricacies.

Practical implications
As the contemporary world grapples with dynamic social and economic challenges and evolving legal frameworks, the landscape of zakat laws and regulations finds itself at a crossroads. While the essence of zakat remains unchanged, modern contexts have introduced new dimensions that require the re-valuation of existing regulatory frameworks. From the intricacies of cross-border zakat to digital assets and emerging financial instruments, zakat governance is undergoing a profound transformation. Therefore, the outcomes that emerged from this study provide deeper insights for policymakers and practitioners in the Islamic world into how some potential interventions can enhance the zakat legal framework. Simplification initiatives, educational campaigns and an effective zakat governance structure aligned strictly with Islamic law can offer a nuanced understanding of zakat payers’ compliance behaviour.

Originality/value
The novelty of this research lies in its focused analysis of zakat law intricacies – a topic that has been overlooked in the literature despite its critical importance.
How financially literate are Indian Muslims? An investigation
Authors: Molla Samim Aktar , Maji Sumit Kumar 
Published: January 2025

Purpose
This study aims to assess the financial literacy (FL) level among Indian Muslims. Moreover, the effort was also directed towards determining the various factors affecting such FL.

Design/methodology/approach
Secondary data on 5,247 respondents from the Financial Inclusion Insight 2017 database was used. FL was measured based on the Standard and Poor’s Global FinLit survey questions. The study used the generalised structural equation model along with relevant statistical and econometric methods.

Findings
The level of FL amongst the Muslims in India was noticed to be poor and highly heterogeneous. Age, marital status, gender, occupation, educational attainment, location, family size, financial inclusion and economic status emerged as the determinants of such FL.

Originality/value
The exploration of FL and the underlying determinants amongst the Indian Muslims has received limited attention in the extant scholarship considering their socio-economic backwardness. In addressing this research gap, to the best of the authors’ knowledge, the study attempts to provide a comprehensive insight into such aspects using a large sample of Indian Muslims for the first time.