bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the adoption and deployment of secure and privacy-preserving IIoT in smart manufacturing: a comprehensive guide with recent advances
Authors: Abdullahi Sani M. , Lazarova-Molnar Sanja 
Published: January 2025

Abstract
The adoption of the Internet of Things (IoT) in smart manufacturing has recently seen a boost in economic and technological advancement. This is attributed to improved operational efficiency resulting from streamlined interoperability, decreased downtime, and real-time processing as compared to conventional manufacturing industries. It also brings with it a massive deployment of intelligent systems and devices from both the Information Technology (IT) and Operational Technology (OT) realms within the Industrial IoT (IIoT) infrastructure, thus creating a heterogeneous interconnectivity. However, such inherent interconnectivity introduces significant security and privacy challenges. To mitigate these challenges, researchers and cybersecurity experts have recently proposed different defense mechanisms for the different facets of the cyber landscape within the IIoT infrastructure. Nevertheless, most of these techniques require major technical expertise to be implemented. Also, there is a lack of specific follow-through guides on how to adopt and implement such mechanisms. This paper aims to fill that gap by providing in-depth guidance on adopting and deploying different defense mechanisms designed to mitigate various cyber threats while ensuring secure and privacy-preserving IIoT infrastructure. The article first emphasizes the implications of cyber threats targeting IIoT tools and infrastructure as well as vulnerabilities emerging due to IT and OT convergence. It then delves into recent state-of-the-art protection mechanisms designed to mitigate these attacks based on a robust framework that includes all defenses. In addition, comprehensive guides to be adopted for a secure and privacy-preserving IIoT are provided. Finally, other challenges and open research questions are presented to pave the way towards efficient deployment of secure and privacy-preserving schemes for the IIoT in smart manufacturing.
In the era of responsible artificial intelligence and digitalization: business group digitalization, operations and subsidiary performance
Authors: Sun Wei , Ren Shuang , Tang Guiyao 
Published: January 2025

AbstractWith the rapid development of digital technologies, responsible AI has become a critical focus for ensuring ethical and socially conscious advancements in business and operations management. The integration of responsible AI practices in business groups’ digital transformations is essential to mitigate potential risks and maximize the positive impact on operational efficiency, supply chain performance, and subsidiary performance. This study aims to examine the consequences and mechanisms through which responsible group digitalization influences business group’s operation management, as manifested in subsidiary performance within the context of the digital economy. Analyzing data from 202 affiliated subsidiaries, we examine the role of HRM collaboration and technological turbulence in facilitating group digitalization. This study enriches the operations management literature and expands the application of ethical and responsible AI practices in digitalization by investigating the relationship between business group digitalization and business operations. Furthermore, this study provides practical implications pertaining to how ethical and responsible practices can guide group digital transformations, business operations and enhance the performance of subsidiaries.
First record of the invasive springtail Hypogastrura viatica occurring synanthropically in East Antarctica
Authors: Onley I. R. , Houghton M. J. , Liu W. P. A. , Shaw J. 
Published: January 2025

Abstract
Antarctica is increasingly vulnerable to invasive species, some of which have already established on the Antarctic Peninsula. The East Antarctic environment is currently recorded to be free from established non-native invertebrates. Here we report the first record of a highly invasive springtail species, Hypogastrura viatica (Collembola: Hypogastruridae), in East Antarctica in 2020. The animals were detected live in the unpacking of imported fresh produce at an Antarctic research station. This is the first record of the transfer of H. viatica to Antarctica via fresh food. Fresh produce is an uncommon pathway for H. viatica, as the species is typically associated with coastal or wet inland environments. Extensive management and surveillance were undertaken following detection, however, taxonomic identification of specimens did not occur until May 2024. We highlight the importance of mandatory reporting and prompt identification of non-native species detections to ensure appropriate responses to future incidents. A lack of species identification may lead to more serious consequences for the environment and ecosystems of East Antarctica.
The Impact of Ethical Leadership on Black Employees’ Workplace Experiences: Echoes from Black Culture and History
Authors: Rice Darryl B. , Maxie Jamila , Massey MaQueba , Edevbie Nero , Day Steven 
Published: January 2025

AbstractThe goal of our work is to explore and highlight factors that contribute to positive experiences of Black employees. To accomplish this, we integrate behavioral ethics research into the Black scholarship literature. Specifically, we focus on the role of ethical leadership. We leverage signaling theory to explain the Black cultural implications associated with ethical leadership and how ethical leaders create racially just workplaces. Across three studies (i.e., one cross-sectional field study and two experimental vignettes), we demonstrate that ethical leadership operates as a welcoming signal for Black employees, which positively impacts Black employees’ evaluations of psychological diversity climate. By cultivating Black employees’ evaluations of psychological diversity climate, Black employees are more likely to be engaged and are less likely to be ostracized in the workplace, which are key indicators of a racially just workplace. Theoretical and practical implications are discussed. We conclude with limitations and future research ideas.
In Their Words: Effective Strategies for Supporting Newly Resettled Refugee Background Adolescents in a Community-Based Program
Authors: Huang Grace H. C. , Marsh Monica Miller , Paul Naila Asad 
Published: January 2025

Abstract
Background
Amidst rapid developmental changes, refugee-background adolescents (RBAs) face unique challenges during resettlement, including adapting to new cultures, languages, and educational systems, while often dealing with pre-migration trauma. These youth need support to navigate educational and career pathways in their host countries. Using asset-based approaches, Teen Response (TR), a community-based program, aims to help newly resettled refugee youth reach their educational and career goals.

Objective
This study examines the strategies used by Teen Response (TR) to support RBAs in their educational and career pathways, as perceived by the participants.

Method
This research is part of a larger study exploring RBAs’ experiences in a community-based program. This paper focuses on the findings from focus group data collected from fifteen RBAs, offering in-depth insights into their experiences and perspectives within a community-based program.

Results
Analysis reveals three pivotal themes that significantly shaped the participants’ experiences: the learning environment, language competency support, cultural knowledge and skills enhancement in career pathways, and the need for extended support. Additionally, RBAs requested extended time in the program and advocated for all schools in the district to have access to TR.

Conclusion
Our findings underscore the importance of community-based support programs responsive to the distinct needs of RBAs and highlight the value of strategies that incorporate youths’ voices and perspectives.
Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study
Authors: Büschges Julia Charlotte , Beyer Ann-Kristin , Schmidt-Trucksäss Arno , Berger Klaus , Neuhauser Hannelore 
Published: January 2025

Abstract
An association of mental health and in particular depression with cardiovascular disease has been shown in adults and to a lesser extent in the young. Recently improved measurement methods of carotid-intima media thickness (CIMT) and carotid stiffness (CS) allow more differentiated analyses of this link. We examined 4,361 participants of the nationwide KiGGS cohort aged 3–17 years at baseline and 14–28 years at follow-up. Using linear and logistic regressions, we analyzed cross-sectional and longitudinal associations of mental health with systolic blood pressure (SBP), body mass index (BMI) and total cholesterol (TC) as well as CIMT and CS from high-resolution carotid sonography at follow-up. Mental health in children was measured with the Strength and Difficulties Questionnaire (SDQ) and in adults with the Mental Health Inventory (MHI-5) and the Patient Health Questionnaire (PHQ-9). Childhood SDQ scores were associated longitudinally with SBP, BMI and TC (-0.03≤ ß≥ 0.02) but not with CIMT or CS one decade later. Similarly, SDQ at follow-up was associated cross-sectionally with SBP, BMI and TC, but not CIMT or CS. MHI-5 scores were not linked to any outcome. PHQ-9 scores in young adults were associated cross-sectionally with SBP and BMI (-0.26≤ ß≥ 0.01), but not with CIMT or CS. Our study shows that children, adolescents and young adults with impaired mental health also have an increased long-term cardiovascular risk through higher BMI and TC. However, in this sample with predominantly mild mental health impairments carotid remodeling was not evident.
Prevalence and incidence of mastocytosis in adults: a Danish nationwide register study
Authors: Jørgensen Maren Poulsgaard , Øvlisen Andreas Kiesbye , Jensen Jonas Faartoft , El-Galaly Tarec Christoffer , Dalager Maiken Glud , Vestergaard Hanne , Broesby-Olsen Sigurd , Severinsen Marianne Tang 
Published: January 2025

Abstract

Introduction
Mastocytosis is a group of rare heterogeneous diseases with a prevalence previously found to be 10–23 per 100,000 persons. More awareness and improvements in the diagnostic methods in later years have led to more patients being diagnosed. Here, we set out to present the prevalence and incidence rate of mastocytosis among the adult Danish population. By merging data from the Danish National Patient Register, the Danish Pathology Register and the Danish Cancer Register we included all adult patients (≥ 18 years) diagnosed with mastocytosis in Denmark prior to 2022. A cohort of 1,594 patients with mastocytosis was identified. The prevalence of mastocytosis was 27.43 per 100,000 persons (95% confidence interval [CI]: 25.95–28.96) as of January 1, 2022, and the 25-year average incidence rate between 1997 and 2021 was 1.21 per 100,000 persons (95%CI: 1.02–1.40) with an increasing incidence rate since 2002. We found a higher prevalence of mastocytosis among adults in the Danish population than previously reported, and an increasing incidence rate during the last 20 years. Increased awareness of the disease and better diagnostic methods most likely contributed to this.
Fault detection and diagnosis of the wastewater nitrate and nitrite sensors using PCA and FDA combined with assessment of the economic and environmental impact of the faults
Authors: Luca Alexandra-Veronica , Simon-Várhelyi Melinda , Mihály Norbert-Botond , Cristea Vasile-Mircea 
Published: January 2025

Abstract
One of the leading challenges in Water Resource Recovery Facility monitoring and control is the poor data quality and sensor consistency due to the tough and complex circumstances of the process operation. This paper presents a new principal component analysis fault detection approach for the nitrate and nitrite concentration sensor based on Water Resource Recovery Facility measurements, together with the Fisher Discriminant Analysis identification of fault types. Five malfunction cases were considered: constant additive error, ramp changing error in time, incorrect amplification error, random additive error, and unchanging sensor value error. The faults’ implementation, fault detection, and identification methods are presented and evaluated in terms of accuracy and promptitude. The models are originating from a municipal plant. The amount of required electrical energy and greenhouse gas released during the Water Resource Recovery Facility operation were assessed for the cases of nitrates and nitrites NO sensor normal and malfunctioning regimes. The environmental and economic evaluations show the benefits of detecting and identifying nitrates and nitrites NO sensor defects aimed at providing efficient and environmentally friendly operation of the Water Resource Recovery Facility. The fault-affected operation cases showed increased values, up to 10% for the total energy demand and 4% for the total greenhouse gas emissions, when they are compared to the normal operation case.
Limits of Empathy, Limits of Alterity ? The Challenges and Shortcomings of Empathy with respect to Children and in Child Abuse Situations
Authors: Serban Claudia 
Published: January 2025

AbstractThe alterity of children seems to raise some peculiar problems for empathy: the child is an alter ego whose difference is often regarded as abnormality or deficiency, and whose relation to adults is ineluctably asymmetric. Accordingly, two related threats endanger the respect and the acknowledgment of the child’s particular otherness: the denial of her subjectivity, as well as domination and violence. The paroxystic expression of these interconnected threats can be found in child abuse situations, which deserve special consideration from the standpoint of a phenomenology of intersubjectivity, embodiment and intercorporeality. At the same time, questions can be raised not only about the child abuse perpetrator’s lack of empathy for the child victim, but also about his or her own call for empathy. Combining a phenomenological approach inspired mostly by Husserl and a feminist approach that makes use of Foucault, the paper first attempts to show that the specific alterity of children and their subjectivity can and must be acknowledged in spite of the variations in embodiment between adults and children. The second moment of the inquiry defines the response of adults to the children’s peculiar otherness in terms of responsibility and care, and analyzes the potentialities for domination and abuse implied by the power of adults over children. Finally, the third and last part of the paper deals with the limits of empathy in front of the moral alterity of child abuse perpetrators, relying on Neige Sinno’s reflexive endeavor in Triste Tigre.
Drugs repurposing in the experimental models of Alzheimer’s disease
Authors: Joodi Sheer A. , Ibrahim Weam W. , Khattab Mahmoud M. 
Published: January 2025

Abstract
The currently approved drugs for Alzheimer’s disease (AD) are only for symptomatic treatment in the early stages of the disease but they could not halt the neurodegeneration, additionally, the safety profile of the recently developed immunotherapy is a big issue. This review aims to explain the importance of the drugs repurposing technique and strategy to develop therapy for AD. We illustrated the biological alterations in the pathophysiology of AD including the amyloid pathology, the Tau pathology, oxidative stress, mitochondrial dysfunction, neuroinflammation, glutamate-mediated excitotoxicity, insulin signaling impairment, wingless-related integration site/β-catenin signaling, and autophagy. Additionally, we demonstrated the different repurposed drugs in the experimental models of AD including the anti-inflammatory, anti-hypertensive, anti-diabetic, antiepileptic, antidepressant and anticancer drugs. Further, we showed the pipeline and FDA approved drugs for AD. The repurposed drugs have a promising therapeutic activity against AD, confirming the value of the drugs repurposing technique to elucidate curative therapy for AD.

Graphical abstract
Religious Fundamentalism, but Not Centrality of Religiosity, is Related to Online Conformity: A Study Based on Asch’s Paradigm
Authors: Misiak Magdalena , Paruzel-Czachura Mariola 
Published: January 2025

AbstractHumans are inherently social beings and are often subject to social influence, a phenomenon known as conformity. But what traits characterize individuals who conform to group opinions? We aimed to examine the potential impact of religiosity and religious fundamentalism on conformity. With the growth of technology, many decisions are now made online, such as during video meetings. This shift prompted us to investigate online conformity in a pre-registered study. To measure conformity, we adapted Asch’s paradigm, using actors in an online video meeting to perform a simple perceptual task based on the classic line-length procedure. Our study focused on two constructs: (1) centrality of religiosity across its dimensions and (2) religious fundamentalism. We hypothesized that higher religiosity and higher levels of religious fundamentalism would be associated with greater online conformity. Consistent with our hypothesis, we found that religious fundamentalism positively correlated with online conformity, whereas centrality of religiosity showed no relationship with conformity in the online setting.
Modelling the Impact of HIF on Metabolism and the Extracellular Matrix: Consequences for Tumour Growth and Invasion
Authors: Spinicci Kévin , Powathil Gibin , Stéphanou Angélique 
Published: January 2025

Abstract
The extracellular matrix (ECM) is a complex structure involved in many biological processes with collagen being the most abundant protein. Density of collagen fibers in the matrix is a factor influencing cell motility and migration speed. In cancer, this affects the ability of cells to migrate and invade distant tissues which is relevant for designing new therapies. Furthermore, increased cancer cell migration and invasion have been observed in hypoxic conditions. Interestingly, it has been revealed that the Hypoxia Inducible Factor (HIF) can not only impact the levels of metabolic genes but several collagen remodeling genes as well. The goal of this paper is to explore the impact of the HIF protein on both the tumour metabolism and the cancer cell migration with a focus on the Warburg effect and collagen remodelling processes. Therefore, we present an agent-based model (ABM) of tumour growth combining genetic regulations with metabolic and collagen-related processes involved in HIF pathways. Cancer cell migration is influenced by the extra-cellular collagen through a biphasic response dependant on collagen density. Results of the model showed that extra-cellular collagen within the tumour was mainly influenced by the local cellular density while collagen also influenced the shape of the tumour. In our simulations, proliferation was reduced with higher extra-cellular collagen levels or with lower oxygen levels but reached a maximum in the absence of cell-cell adhesion. Interestingly, combining lower levels of oxygen with higher levels of collagen further reduced the proliferation of the tumour. Since HIF impacts the metabolism and may affect the appearance of the Warburg Effect, we investigated whether different collagen conditions could lead to the adoption of the Warburg phenotype. We found that this was not the case, results suggested that adoption of the Warburg phenotype seemed mainly controlled by inhibition of oxidative metabolism by HIF combined with oscillations of oxygen.
Prevalence Estimation Methods for Time-Dependent Antibody Kinetics of Infected and Vaccinated Individuals: A Markov Chain Approach
Authors: Bedekar Prajakta , Luke Rayanne A. , Kearsley Anthony J. 
Published: January 2025

Abstract
Immune events such as infection, vaccination, and a combination of the two result in distinct time-dependent antibody responses in affected individuals. These responses and event prevalence combine non-trivially to govern antibody levels sampled from a population. Time-dependence and disease prevalence pose considerable modeling challenges that need to be addressed to provide a rigorous mathematical underpinning of the underlying biology. We propose a time-inhomogeneous Markov chain model for event-to-event transitions coupled with a probabilistic framework for antibody kinetics and demonstrate its use in a setting in which individuals can be infected or vaccinated but not both. We conduct prevalence estimation via transition probability matrices using synthetic data. This approach is ideal to model sequences of infections and vaccinations, or personal trajectories in a population, making it an important first step towards a mathematical characterization of reinfection, vaccination boosting, and cross-events of infection after vaccination or vice versa.
Short-term application of melatonin can partially restore the mineral balance in heavy-metal treated Amaranthus cruentus var. ‘Pribina’
Authors: Hunková Júlia , Lancíková Veronika , Hricová Andrea , Tomka Marián , Kačírová Jana 
Published: January 2025

Abstract
An excess amount of particular metal ions can cause nutrient imbalance and inhibit plant growth and development. In this preliminary study, the short-term (2 weeks) and long-term (6 weeks) application was carried out to investigate the potential ameliorative effect of foliar application of melatonin and reveal the changes in ion profiles of grain amaranth Amaranthus cruentus var. ‘Pribina’ treated with Cd, Zn, and Mn. Nine elements (Ca, K, Mg, Na, Cu, Fe, Cd, Zn, Mn) were examined using inductively coupled plasma optical emission spectrophotometry. Different ionomic responses were observed in root and shoot tissues. The results showed that Cu, K, Mn and Na were the most affected elements, which significantly changed after heavy metal applications. Application of Zn had the most prominent effect on the alternations in ion concentrations. In addition, short-term melatonin supplementation reduced Cd and Mn root-to-shoot translocation. No marked changes were recorded between short-term and long-term applications, indicating that short-term use is sufficient for restoring the mineral balance, albeit not for all elements.
The Role of Radiotherapy in the Management of Melanoma Brain Metastases: An Overview
Authors: Lens Marko , Schachter Jacob 
Published: January 2025

Opinion statement
Clinical management of melanoma brain metastases is complex and requires multidisciplinary approach. With close collaboration between neurosurgeons, radiation oncologists and medical oncologists, melanoma patients with brain are offered different treatment modalities: surgery, radiation therapy, systemic therapy or combined treatments. Radiation therapy (whole brain radiotherapy- WBRT and stereotactic radiosurgery- SRS) is an integral part of treating melanoma brain metastases. Use of immunotherapy (checkpoint inhibitors) and targeted therapy (BRAF/MEK inhibitors) significantly changed the outcome in patients with melanoma metastases. Currently, ipilimumab and nivolumab (COMBO) is the preferred first-line systemic therapy for all patients with asymptomatic brain metastases, regardless of BRAF status (BRAF wild-type and BRAF-mutated). Although at the moment there is no consensus on the concomitant use of SRS and COMBO, results from clinical trials suggest that this combined treatment modality should be considered the standard of care for melanoma patients with brain metastases. However, further clinical research is required to define optimal treatment modalities for routine management of melanoma brain lesions.