bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real‐Time Tumor‐Tracking and Photothermal‐Enhanced Chemotherapy
Authors: Sun Tao , Zhang Guangping , Ning Tingting , Chen Qinjun , Chu Yongchao , Luo Yifan , You Haoyu , Su Boyu , Li Chao , Guo Qin , Jiang Chen 
Published: August 2021

AbstractA versatile tumor‐targeting stimuli‐responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal‐enhanced chemotherapy. A quenched photosensitizer (“off” state) is developed and escorted into a tumor‐targeting oxaliplatin‐embedded micelle. Once reaching the tumor cell, the micelle is clasped to release free oxaliplatin, as well as the “off” photosensitizer, which is further activated (“turned‐on”) in the tumor reducing microenvironment to provide optical imaging and photothermal effect. The combined results from hyperthermia‐enhanced chemotherapy, deep penetration, perfused O2, and the leveraged GSH‐ROS imbalance in tumor cells are achieved for improved antitumor efficacy and reduced systematic toxicity.
Measurement errors in index trader positions data: Is the price pressure hypothesis still invalid?
Authors: Bohl Martin T. , Branger Nicole , Trede Mark 
Published: August 2021

AbstractIn this paper, we examine whether the repeated rejection of Masters's price pressure hypothesis is robust with respect to measurement errors in index trader positions data. We allow for autocorrelated errors and a potential impact of index trader positions on both the level and volatility of commodity returns. The resulting state‐space model is estimated via particle Markov chain Monte Carlo (PMCMC). The empirical investigation relies on weekly data for 12 commodities listed in the SCoT and DCoT reports from 2006 to 2020. Our empirical findings show that the rejection of the price pressure hypothesis is robust concerning the inclusion of measurement errors in index trader positions data.
Nγ‐Hydroxyasparagine: A Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases
Authors: Xia Yiyin , To Janet , Chan Ning‐Yu , Hu Side , Liew Heng Tai , Balamkundu Seetharamsing , Zhang Xiaohong , Lescar Julien , Bhattacharjya Surajit , Tam James P. , Liu Chuan‐Fa 
Published: August 2021

AbstractPeptidyl asparaginyl ligases (PALs) are powerful tools for peptide macrocyclization. Herein, we report that a derivative of Asn, namely Nγ‐hydroxyasparagine or Asn(OH), is an unnatural P1 substrate of PALs. By Asn(OH)‐mediated cyclization, we prepared cyclic peptides as new matrix metalloproteinase 2 (MMP2) inhibitors displaying the hydroxamic acid moiety of Asn(OH) as the key pharmacophore. The most potent cyclic peptide (Ki=2.8±0.5 nM) was built on the hyperstable tetracyclic scaffold of rhesus theta defensin‐1. The Asn(OH) residue in the cyclized peptides can also be readily oxidized to Asp. By this approach, we synthesized several bioactive Asp‐containing cyclic peptides (MCoTI‐II, kB2, SFTI, and integrin‐targeting RGD peptides) that are otherwise difficult targets for PAL‐catalyzed cyclization owing to unfavorable kinetics of the P1‐Asp substrates. This study demonstrates that substrate engineering is a useful strategy to expand the application of PAL ligation in the synthesis of therapeutic cyclic peptides.
Elasmobranch fishing and trade in Sarawak, Malaysia, with implications for management
Authors: Booth Hollie , Chaya Faith , Ng Sylvia , Tan Veni , Rao Madhu , Teepol Batrisyia , Matthews Elizabeth , Lim Annie , Gumal Melvin 
Published: August 2021

AbstractMany shark and ray (elasmobranch) species are threatened with extinction, due to overfishing and commercial tradeSarawak is situated in Malaysian Borneo in the Coral Triangle: a global priority region for elasmobranch conservation. Malaysia is the world’s eighth largest elasmobranch fishing nation, and Sarawak is one of Malaysia’s largest fishing states, yet there are limited species‐specific data on catch and trade of elasmobranchs to support conservation and fisheries management decisions.This study presents landing site and market survey data, collected in Sarawak from January 2017 to December 2019. Geographical, temporal and operational trends in volumes of catch and trade are explored; the total volume, value and species composition of Sarawak's local elasmobranch markets is estimated; and simple size‐based indicators are used to assess the sustainability of elasmobranch utilization for several conservation‐priority and frequently traded species, including Critically Endangered and CITES‐listed scalloped hammerhead sharks (Sphyrna lewini) and bottlenose wedgefish (Rhynchobatus australiae).The results conservatively estimate that >26,500 elasmobranchs (~90,000 kg) are locally traded in Sarawak annually, worth ~US$125,000 per year at the market level.Trade is dominated by small to medium‐sized coastal requiem sharks (Carcharhinidae) and stingrays (Dasyatidae), with endangered and CITES‐listed species making up 26% and 32% of total landings and trade, respectively.High proportions of immature individuals were recorded, with evidence of overfishing for several species, based on simple size‐based indicators.Several options are outlined for improving management of elasmobranch fishing and trade in the future, including spatio‐temporal closures and live release protocols, which could help to reduce the mortality of critically endangered species and implement CITES. Such measures could have large conservation impacts with limited socio‐economic cost, since these species make up <5% of the total value of the elasmobranch market. However, management plans need to be co‐designed with full participation of affected coastal communities in order to be ethical and effective.
Activation of Hypothalamic AMP‐Activated Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis
Authors: Seoane‐Collazo Patricia , Rial‐Pensado Eva , Estévez‐Salguero Ánxela , Milbank Edward , García‐Caballero Lucía , Ríos Marcos , Liñares‐Pose Laura , Scotece Morena , Gallego Rosalía , Fernández‐Real José Manuel , Nogueiras Rubén , Diéguez Carlos , Gualillo Oreste , López Miguel 
Published: August 2021

ObjectiveTo investigate whether thermogenesis and the hypothalamus may be involved in the physiopathology of experimental arthritis (EA).MethodsEA was induced in male Lewis rats by intradermal injection of Freund's complete adjuvant (CFA). Food intake, body weight, plasma cytokines, thermographic analysis, gene and protein expression of thermogenic markers in brown adipose tissue (BAT) and white adipose tissue (WAT), and hypothalamic AMP‐activated protein kinase (AMPK) were analyzed. Virogenetic activation of hypothalamic AMPK was performed.ResultsWe first demonstrated that EA was associated with increased BAT thermogenesis and browning of subcutaneous WAT leading to elevated energy expenditure. Moreover, rats experiencing EA showed inhibition of hypothalamic AMPK, a canonical energy sensor modulating energy homeostasis at the central level. Notably, specific genetic activation of AMPK in the ventromedial nucleus of the hypothalamus (a key site modulating energy metabolism) reversed the effect of EA on energy balance, brown fat, and browning, as well as promoting amelioration of synovial inflammation in experimental arthritis.ConclusionOverall, these data indicate that EA promotes a central catabolic state that can be targeted and reversed by the activation of hypothalamic AMPK. This might provide new therapeutic alternatives to treat rheumatoid arthritis (RA)–associated metabolic comorbidities, improving the overall prognosis in patients with RA.
Flipped spotters learning model: An innovative student activity‐based strategy. A preparation tool for anatomy practical examinations in medical education
Authors: Łopińska Marcelina , Gielecki Jerzy Stanisław , Żurada Anna 
Published: August 2021

AbstractThe flipped spotters learning model is a modern student activity‐based and learner‐centered method in medical education. The aim of the study was to determine if the flipped spotters learning model improves students' learning. Participants were 1214 medical students of Polish (PD) and English (ED) divisions between 2013 and 2019 academic years at the University of Warmia and Mazury in Olsztyn, Poland. They were divided into a traditional group (control group) and a flipped spotters learning group (treatment group). Each flipped spotters learning group was asked to label anatomical structures on various specimens according to the structures name list prepared by the teacher on the multiple stations. The flipped spotters learning group leaders were instructed to take pictures with the appropriately marked structures on each of the human body prosections. After completion of the class, each flipped spotters team received photos for evaluation. In the flipped spotters learning model, the students strengthened their skills and knowledge by matching specimens independently as a form of practical laboratory activities. Students' performance in gross anatomy practical examinations between the group utilizing the flipped spotters learning model, and the group with the traditional teaching model was compared. Students participating in the treatment group achieved, on average 9.9 percentage points higher among PD students, and 13.0 percentage points higher among ED students than the control group in all nine practical examinations (the effect size ranging from 0.47 to 0.95). The results suggest the positive impact of flipped spotters model on improving student's performance in the practical examinations.
Production of cello‐oligosaccharides through the biorefinery concept: A technical‐economic and life‐cycle assessment
Authors: Barbosa Fernando C. , Nogueira Guilherme P. , Kendrick Emanuele , Franco Telma T. , Leak David , Dias Marina O. S. , Cavaliero Carla K. N. , Goldbeck Rosana 
Published: August 2021

AbstractProducers look for co‐products to increase the value chain and production flexibility. With a high market aggregate value, the production of cello‐oligosaccharides (COS) as functional oligosaccharides from cellulosic substrates has been investigated. As COS/cellopentaose production process are rarely described in the literature, this study estimated the cellopentaose production cost and performed a life‐cycle assessment of the cellopentaose production process previously developed using sugarcane straw as a substrate. The results demonstrated that, through the six scenarios studied, it was possible to obtain a cellopentaose unit production cost varying between USD 0.40 and 1.15/mg, and that optimization in the upstream sector can reduce the total plant direct cost and the overall life‐cycle impact. The results also suggested that a better understanding of the hydrolysis solid/liquid proportion is necessary to reduce the bulk material cost. An environmental impact reduction of between 16.2% and 19.9% was also observed. In terms of the integrated biorefinery concept, sugarcane straw fermentation represents a prospective technology for the production of COS. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Market prospects for biochar production and application in California
Authors: Thengane Sonal K. , Kung Kevin , Hunt Josiah , Gilani Haris R. , Lim C. Jim , Sokhansanj Shahabaddine , Sanchez Daniel L. 
Published: August 2021

AbstractThe state of California could play an important role in emerging markets for biochar, due in part to the availability of low‐value biomass resources and their potential for use in agriculture sector. In this study, we assess the scale of production and use, and comment on potential markets for biochar in California. We explore various sectors for the application of biochar produced from local biomass using surveys and a market‐sizing approach. A market‐oriented approach for biochar innovation and the ecosystem around a biochar producer is also discussed. Next, we identify barriers to biochar market success in the present and the near future based on a survey of local producers. Among the barriers analyzed, access to capital investment for scale‐up is the biggest barrier experienced by a majority of producers, followed by market and demand. When grouped under different categories, the extent of barriers decreased in the order: market > scale‐up > technical > socio‐political > environmental. Most producers anticipate that revenues from carbon offset credits would help them scale up their facilities and expand the biochar market. In the near future, soil‐based applications of biochar could be the most likely market for biochar, followed by filtration, livestock feed, and manure management. As the industry evolves, rewarding carbon credits, increasing awareness and improving production processes are expected to help commercialize biochar. Finally, we offer recommendations to promote the growth of biochar in California. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art
Authors: Molinari Romina , Merendino Nicolò , Costantini Lara 
Published: August 2021

AbstractThe human intestine contains an intricate ecological community of bacteria, referred as the gut microbiota, which plays a pivotal role in the host homeostasis. Multiple factors could interfere with this delicate balance, thus causing a disruption of the microbiota equilibrium, the so called dysbiosis. Gut microbiota dysbiosis is involved in gastrointestinal and extra‐intestinal metabolic diseases, as obesity and diabetes. Polyphenols, present in a broad range of plant foods, are known to have numerous health benefits; however, their beneficial effect on pre‐existing dysbiosis is less clear. Indeed, in most of the conducted animal studies the administration of polyphenols or foods rich in polyphenols occurred simultaneously with the induction of the pathology to be examined, then analyzing the preventive action of the polyphenols on the onset of dysbiosis, while very low studies analyzed the modulatory activity of polyphenols on the pre‐existing dysbiosis. For this reason, the present review aims to update the current information about the modulation of the pre‐established gut microbiota dysbiosis by dietary phenolic compounds in a broad range of disorders in both animal studies and human trials, distinguishing the preventive or treatment approaches in animal studies. The described studies highlight that dietary polyphenols, exerting prebiotic‐like effects, can modulate the pre‐existing dysbiosis stimulating the growth of beneficial bacteria and inhibiting pathogenic bacteria in both animal models and humans. Anyway, most of the conducted studies are related to obesity and metabolic syndrome, and so further studies are needed to understand this polyphenols' ability in relation to other pathologies.
Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives
Authors: Mahomoodally Mohamad Fawzi , Zengin Gokhan , Sinan Kouadio Ibrahime , Ak Gunes , Sadeer Nabeelah Bibi , Angeloni Simone , Mustafa Ahmed M. , Caprioli Giovanni , Maggi Filippo , Cakilcioglu Ugur , Kaplan Alevcan , Babacan Ebru Yuce , Bouyahya Abdelhakim , Darendelioglu Ekrem 
Published: August 2021

AbstractThe aim of the present study was to quantify selected phenolic compounds, determine antioxidant activity and enzyme inhibitory effects of the aerial parts of Alkanna trichophylla Hub.‐Mor. (A. trichophylla) and Convolvulus galaticus Rost.ex Choisy (C. galaticus) extracts prepared by homogenizer‐assisted extraction (HAE), maceration (MAC) and infusion techniques. This is the first time such study has been designed to validate the phytochemical composition and bioactivity of these plants. Multivariate analysis was conducted on collected data. Rutin and caffeoylquinic acid derivatives were the most significant compounds in A. trichophylla and C. galaticus, respectively. The highest antioxidant activity of A. trichophylla was mostly exhibited by HAE/methanolic extracts as determined by DPPH, ABTS, FRAP (51.39, 112.70 and 145.73 mg TE/g, respectively) and phosphomolybdenum (2.05 mmol TE/g) assays. However, significant antioxidant activities varied within the extracts of C. galaticus. HAE/methanolic extract of A. trichophylla significantly depressed AChE (2.70 mg GALAE/g), BChE (5.53 mg GALAE/g) and tyrosinase (26.34 mg KAE/g) activities and that of C. galaticus inhibited AChE (2.04 mg GALAE/g), tyrosinase (31.25 mg KAE/g) and α‐amylase (0.53 mmol ACAE/g) activities significantly. We concluded that HAE was the most efficient extraction technique as high yield of compounds and promising bioactivities were recorded from extracts prepared. Multivariate analysis showed that types of solvents influenced recovery of compounds and biological activities. This research study can be used as one methodological starting point for further investigation on these plants as all results are clearly promising and open the door to further research challenges such as cytotoxicity evaluation, molecular docking analysis, and more screening of pharmacological actions.
Devastating iatrogenic internal carotid artery rupture in endoscopic endonasal surgery rescued by a covered stent
Authors: Fu Xiaojie , Quan Tao , Yuan Yongjie , Xu Haowen , Guan Sheng 
Published: August 2021

AbstractIatrogenic ICA injury is a life‐threatening and underreported complication of EES. For selected patients, covered stent implantation is the best and only way to block the rupture spot immediately and maintain ICA blood flow.
Is it just an obstructive pyelonephritis?
Authors: Teixeira Mariana , Ferreira Filipa Coroado , Naia Leonor , Pinheiro Inês , Rabadão Tiago , Aveiro Marcelo , Ferreira Erica , Silva Fernando 
Published: August 2021

AbstractPyelocaliceal obstruction is a diagnostic challenge, and it is important to identify the obstruction cause. Some patients present extra‐renal compressive masses that need further imagiologic investigation and a biopsy, to establish the diagnosis.
Focal eosinophilic infiltration of the liver, benign or malignant?
Authors: Claeys Wouter , Delie Anke , Smeets Peter , De Scheerder Marie‐Angelique , Degroote Helena , Verhelst Xavier , Van Vlierberghe Hans , Geerts Anja 
Published: August 2021

AbstractFocal eosinophilic infiltration (FEI) of the liver shares imaging characteristics with malignant hepatic lesions but should be suspected when concomitantly observing eosinophilia. While in itself benign, the cause of FEI should be sought and treated.
Concomitant occurrence of genetically distinct Hodgkin lymphoma and primary mediastinal lymphoma
Authors: Dubois Sydney , Ruminy Philippe , Bohers Elodie , Viailly Pierre‐Julien , Veresezan Liana , Picquenot Jean‐Michel , Bobée Victor , Viennot Mathieu , Penther Dominique , Camus Vincent , Thieblemont Catherine , Pouaty Camille , Tilly Hervé , Jardin Fabrice 
Published: August 2021

AbstractSynchronous Hodgkin Lymphoma and Primary Mediastinal B‐cell Lymphoma is possible, with molecular analyses proving the absence of clonal filiation between both entities. This suggests a common etiology but the existence of two divergent clones.
Psychogenic fever due to worry about COVID‐19: A case report
Authors: Imataki Osamu , Uemura Makiko 
Published: August 2021

AbstractPsychogenic fever is stress‐related hyperthermia that is recognized as a psychosomatic condition. We treated a 46‐year‐old Japanese man who was worrying about the coronavirus infection (COVID‐19) and had a fever with a maximum temperature of 38.1℃. The patient was tested twice for SRAS‐CoV‐2 using polymerase chain reaction (PCR), but both tests were negative. All tests were negative for organic diseases, including infections, allergy/collagen diseases, endocrine disorders, malignancies, and drugs‐induced conditions. The more he doubted the COVID‐19 in him, the more he complained of the already known various symptoms, such as smelling disorder. The patient believed firmly that he had COVID‐19 because PCR can be false negative. Finally, the patient was treated with the anxiolytic, loflazepate, at 4 mg/day. This treatment was highly effective. The patient's serum IL‐6 was 1.1 pg/ml (≤4.0). The patient was diagnosed with psychogenic fever due to irrational worry over coronavirus. Such typical cases should be treated with an anxiolytic.
An unusual case of obstructive uropathy
Authors: Xenou Antigoni , Boulas Konstantinos A. , Nathanailidou Maria , Kyriakidou Eytyxia , Paraskeva Aikaterini , Triantafyllidis Alexandros , Chatzipourganis Konstantinos , Hatzigeorgiadis Anestis 
Published: August 2021

AbstractAlthough inguinal bladder hernia associated with obstructive uropathy is an extremely rare entity, it should be suspected in elderly patients with bladder outlet obstruction presented with inguinal hernia and lower urinary tract symptoms.
Kaposi‐Juliusberg Varicelliform Eruption complicating Darier disease: May cannabinoid abuse be an underestimated risk factor?
Authors: Russo Roberto , Labate Laura , Cozzani Emanuele , Delfino Emanuele , Bassetti Matteo , Parodi Aurora 
Published: August 2021

AbstractCannabinoid abuse may facilitate disseminated skin infection by herpes viruses in predisposed patients. These patients should be counselled about that.
Chemical‐induced aseptic meningitis as a result of intrathecal hydromorphone therapy: Case report
Authors: Willhite Sydney , Juloori Sangeeta 
Published: August 2021

AbstractChemical meningitis, though rare, is a diagnosis of exclusion that must be considered in patients presenting with neurologic symptoms of undetermined cause. It is likely that any substance in contact with CSF can be the culprit.
Iatrogenic diversion of the inferior vena cava into the left atrium diagnosed 43 years after surgical atrial septal defect closure
Authors: Doi Toshio , Nagao Kanetsugu , Higashida Akihiko , Aoki Masaya , Yokoyama Shigeki , Yamashita Shigeyuki , Yamashita Akio , Fukahara Kazuaki , Yoshimura Naoki 
Published: August 2021

AbstractThe diversion of the inferior vena cava into the left atrium after surgical atrial septal defect closure is a fatal complication. Cases of atrial septal defect with no inferior rim should be treated with this complication in mind.
Guiding catheter inner lumen damage during percutaneous coronary intervention
Authors: Osherov Azriel , Jafari Jamal , Yosefy Chaim , Gallego‐Colon Enrique 
Published: August 2021

AbstractGuiding catheter damage and body wire intermingling are uncommon complications of standard operational procedures. Optimal application of this device includes replacing the small guiding catheter upon excessive resistance during stent insertion.
Covered stent grafts for relining of chronically occluded femoro‐popliteal bypasses in frail patients
Authors: van Nistelrooij Anna M. J. , van ’t Sant Hans Pieter , Schouten Olaf 
Published: August 2021

AbstractIn four high‐risk patients with chronically occluded femoro‐popliteal bypass suffering from Rutherford 4‐5 chronic limb threatening ischemia we performed, as an alternative for redo surgery, endovasculair relining with covered stent grafts. During follow‐up (3, 8, 14 and 20 months) one patient had redo percutaneous intervention and eventually below‐the‐knee amputation.
Scintigraphy false‐positive results for cardiac amyloidosis in a patient with Danon disease
Authors: Antukh Dmitry , Shchekochikhin Dmitry , Rosina Teona , Mershina Elena , Larina Olga , Pasha Sergey , Zaklyazminskaya Elena , Sinitsyn Valentin , Moiseev Sergey 
Published: August 2021

AbstractCommon diagnostic approach in patients with suspected cardiac amyloidosis includes cardiac magnetic resonance imaging and scintigraphy. We report the first clinical case of false‐positive results of scintigraphy in a patient with Danon disease.