bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Messaging Best Promotes a 20-year-old Women’s Intention to have Cervical Cancer Screening?
Authors: Miyoshi Ai , UEDA Yutaka , YAGI Asami , KIMURA Toshihiro , KOBAYASHI Eiji , HIRAMATSU Kosuke , NAKAGAWA Satoshi , KIMURA Tadashi 
Published: May 2021

Abstract
Background: Because they have not been HPV-vaccinated, the vast majority of women in Japan are defenseless against HPV-caused cervical cancer. Cervical cancer screening has become their only means for intervention early enough to save their uterus and often, their lives. Unfortunately, the cervical cancer screening rate in Japan has dropped recently to 10.2% for 20-25-year-olds. We need to recommend earlier, more frequent, and more effective screening for them. We have assessed several factors that could promote the intention of Japanese women toward having cervical cancer screening. Method: We conducted an online survey of 412 Japanese women. Half of the respondents were given an information sheet concerning cervical cancer, the remaining half wasn’t. After this educational intervention, we quizzed them about their knowledge concerning cervical cancer, about their and their family’s cervical cancer screening practices, about having talks with their family about cervical cancer, and their intentions for having cervical cancer screening. Among the 127 women who admitted having had a sexual relationship, we evaluated their intention toward having cervical cancer screening. We assessed several factors that were likely to influence their intention to have cervical cancer screening. Results: We determined that an education with an information sheet, whether or not they had ever talked with their family about cervical cancer, and whether members of their family had ever had cervical cancer screening, were associated with an effective impact on the women's positive intention to have cervical cancer screening. Knowing that cervical cancer is becoming more common among young women, that cervical cancer could influence their fertility, and that cervical cancer screening could prevent any lesions from advancing to become invasive cancer, 3 were also associated with an effective impact on the women's positive intention. Conclusion: Personal educational intervention, talking with their family about cervical cancer, and the general health consciousness of their family, were all associated with an effective impact on the women's positive intentions toward cervical cancer screening. It is likely that the messaging for the need for cervical cancer screening for 20-year-olds targeting their innate desire to preserve their fertility would most effectively resonate with these young women.
Regional Air Quality: Forest Fires Impacts of SO2 Emissions on Air Pollutants in the Himalayan Region of Uttarakhand, India
Authors: GAUTAM ALOK SAGAR , Kumar Sanjeev , Gautam Sneha , Ram Kirpa , Siingh Devendraa , Ambade Balram , Sharma Manish 
Published: May 2021

Abstract
Sulfur dioxide (SO2) is a toxic with adverse health effects on respiratory tract, eyes, mucous membranes and skin. In the present study, the continuous ground-based SO2 monitoring has planned over Srinagar Garhwal Valley of Uttarakhand. In the monsoon (M-2018), Post-monsoon (PoM-2018), Winter (W-2019) & Pre-monsoon (PrM-2019) & & M-2019 have high SO2 concentrations (3.66 ± 2.05 µg/m3, 5.54 ± 2.23 µg/m3, 6.42 ± 1.79 µg/m3, 7.56 ± 3.53 µg/m3 6.45 ± 3.49 µ g/m3) at1900 LT, 2000 LT, 1800 LT, 1900 LT &1900 LT attributed mainly due to biomass burning and long-range transportation of pollutants. A drastic change in the SO2 concentration has been observed from 4.81 to 17.39 µg/m3 during May 2019 with a strong correlation of 0.61 with fire-counts during extensive forest fire. Whereas Jul 2018 (1.07 ± 0.82 µg/m3) showed the lowest SO2 concentration due to wet scavenging process. Temperature, humidity and wind speed have significant correlation with SO2 in different season. Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model trajectories and cluster analysis indicate the transportation of air mass from the Gulf region, Sahara Desert, Pakistan, Afghanistan to Srinagar with a significant contribution of 40.43–72.29% air mass. We have also observed weekend effects (reduction in the pollutant concentration) in Jul 2018, Sep 2018, Feb 2019, Apr 2019 and May 2019.
Analysis of Pressure Response at an Observation Well against Pressure Build-Up by Early Stage of CO2 Geological Storage Project
Authors: Qiang Sun , Sasaki Kyuro , Sugai Yuichi , Nguele Ronald , Zhang Xiaoming 
Published: May 2021

Abstract
To ensure a safe and stable CO2 storage, pressure responses at an observation well is expected to be an important and useful field monitoring items to estimate the CO2 storage behaviors and the aquifer parameters during and after injecting CO2, because it can detect whether the injected CO2 leaks to the ground surface or the bottom of the sea. In this study, pressure responses were simulated to present design factors such as well location and pressure transmitter of the observation well. Numerical simulations on the pressure response and the time-delay from pressure build-up after CO2 injection were conducted by considering aquifer parameters and distance from the CO2 injection well to an observation well. The measurement resolution of a pressure transmitter installed in the observation well was presented based on numerical simulation results of the pressure response against pressure build-up at the injection well and CO2 plume front propagations. Furthermore, the pressure response at an observation well was estimated by comparing the numerical simulation results with the curve of CO2 saturation and relative permeability. It was also suggested that the analytical solution can be used for the analysis of the pressure response tendency using pressure build-up and dimensionless parameters of hydraulic diffusivity. Thus, a criterion was established for selecting a pressure transducer installed at an observation well to monitor the pressure responses with sufficient accuracy and resolution, considering the distance from the injection well and the pressure build-up at the injection well, for future CCS projects.
Is Financial Globalization Polluting? – Symmetric and Asymmetric Effects of External Liabilities on CO2 Emissions in the MENA Region
Authors: Gaies Brahim , Nakhli Mohamed Sahbi , SAHUT Jean-Michel 
Published: May 2021

Abstract
This paper aims to study the symmetric and asymmetric effects of financial globalization on CO2 emissions in the MENA region. Using a panel dataset of seven non-OPEC MENA countries over the period 1980-2014, we perform a comprehensive econometric analysis based on the panel ARDL and non-linear panel ARDL (NARDL) models and a battery of tests, including cross-sectional dependence tests, second-generation unit root tests and cointegration tests. The findings reveal a significant long-term impact of financial globalization on CO2 emissions that can be symmetric or asymmetric depending on the nature of financial globalization. While external debt liabilities appear to be polluting because they increase CO2 emissions significantly and linearly, the long-term impact of FDI and portfolio investment liabilities on CO2 emissions is asymmetric, with only negative shocks of FDI and portfolio investment decreasing CO2 emissions. This suggests that financial globalization through foreign investment (FDI and portfolio investment) is more environmentally friendly than financial globalization through debt, which provides interesting insights for policy makers.
Using The Reasoned Action Approach To Analyze Differences In Physical Activity Behaviors of College Student Athletes During The Early COVID-19 Shutdown.
Authors: Branscum Paul W. , Geller Karly S. , Branson Olivia A. 
Published: May 2021

Abstract
Background: The purpose of this study was to utilize the Reasoned Action Approach (RAA) to evaluate the impact of COVID-19 on the physical activity (PA) behaviors of college student athletes, including aerobic, muscle strengthening, and sport-specific conditioning PA. Theory-based determinants of intentions to all three PA behaviors were assessed using multiple regression analyses.Results: Outcomes demonstrated that perceived norms, perceived behavioral control, and attitudes predicted a significant amount of the variance of intentions for muscle strengthening PA (44.8%) and a moderate amount for aerobic PA (28.5%) and conditioning PA (35.2%). Additionally, intentions, attitudes, perceived norms, and perceived behavioral control were compared between PA type using a repeated measures ANOVA, and results showed there were significant differences. Conclusion: These findings can assist public health practitioners, coaches, and trainers to develop and implement more effective interventions and training sessions for all types of PA with college athletes.
National And Subnational Incidence of Bladder Cancer In Iran: Results of The Iranian National Population-Based Cancer Registry Over A 12-Year Period
Authors: Nowroozi Mohammad Reza , Amini Erfan , Farkhani Ehsan Mosa , Nowroozi Ali , Ayati Mohsen , Rezazadeh Shahin , Momeni Seyed Ali , Bokaie Saied , Sharifi Laleh 
Published: May 2021

Abstract
Background: Bladder cancer is one of the most common cancers worldwide and its incidence and mortality rates vary globally due to genetic variation, population age and exposure to risk factors. In the present study we aim to report national and subnational incidence of bladder cancer in Iran between 2003 and 2015.Methods: This population-based study investigate the age-standardized incidence rates (ASRs) of bladder cancer between 2003 and 2015 in Iran and its 32 provinces using last updated data from national cancer registry system of non-communicable disease center of Iran Ministry of Health, and Medical Education. Results: ASR of bladder cancer increased from 8.35 in 2003 to 13.57 in 2015 in men. ASR of bladder cancer also showed a mild increase in females, 2.12 in 2003 versus 2.86 in 2015.Conclusion: In conclusion, we observed an increasing trend of bladder cancer incidence in Iran, highlighting the disease as a potentially major health problem in the future. Therefore, it is necessary for health organizations to implement effective educational, preventive and therapeutic programs in the country to prevent further increase of disease burden.
High Rates of Treatment Stage Migration For Early Hepatocellular Carcinoma and Its Association With Adverse Impact On Outcomes: A Multicenter Study
Authors: Loo Kee Fong , Woodman Richard , Bogatic Damjana , Muller Kate , Chandran Vidyaleha , Chinnaratha Mohamed Asif , Bate John , Campbell Kirsty , Maddison Matthew , Narayana Sumudu , Le Hien , Pryor David , Wigg Alan 
Published: May 2021

Abstract
Background & Aims:The rate of contraindications to percutaneous ablation (PA) for inoperable early HCC, and subsequent outcomes is not well described. We investigated the prevalence and outcomes of inoperable early HCC patients with contraindications to PA, resulting in treatment stage migration (TSM). Methods:BCLC 0/A patients diagnosed between September 2013 and September 2019 across five hospitals were identified. Primary endpoint was proportion of BCLC 0/A HCCs with contraindications to PA. Secondary endpoints included overall survival (OS), local tumour control (LTC) and recurrence-free survival (RFS). The causal effects of PA versus TSM were assessed using a potential outcome means (POM) framework in which the average treatment effects (ATE) of PA were estimated after accounting for potential selection bias and confounding.Results:245 patients with inoperable BCLC 0/A HCC were identified. 140 (57%) had contraindications to PA and received TSM therapy, 105 (43%) received PA. The main contraindication to PA was difficult tumour location (47%). Patients who received TSM therapy had lower median OS (2.1 versus 5.3years), LTC (1.0 versus 4.8years), and RFS (0.8 versus 2.7years); p<0.001 respectively, compared to PA. The ATE for PA versus TSM yielded an additional 1.02years (p=0.048), 2.87years (p<0.001) and 1.77years (p<0.001) for OS, LTC and RFS respectively. 3-year LTC after PA was suboptimal (63%).Conclusions:Our study highlights high rates of contraindication to PA in early HCCs, resulting in TSM and poorer outcomes. The local recurrence rate after PA was also high. Both findings support exploration of alternative ablative options for early HCCs.
Optimization of Cutting Parameters for Improving Machining Quality Andproduction Rate in Drilling of CFRP Composites
Authors: Wang Qian , Jia Xiaoliang 
Published: May 2021

Abstract
Carbon fiber reinforced polymer (CFRP) composites need to be machined by operations like trimming, reaming and drilling for the dimensional tolerance and final assembly. This paper presents a cutting parameters optimization method for drilling of CFRP composites to improve hole quality and production efficiency. Hole quality indicators including exit delamination and average surface roughness are expressed as functions of cutting parameters based on the regression analysis of experimental data. Multi-objective optimization of cutting parameters for decreasing exit delamination and surface roughness, increasing material removal rate is accomplished with non-dominated sorting genetic algorithm Ⅱ (NSGA-Ⅱ). Optimization results are large numbers of Pareto optimal solutions widely distributed in the objective space, the reliability of Pareto optimal solutions is checked with the global convergence and spacing distance. Moreover, posterior analysis is implemented to identify key solutions of better performance from the Pareto optimal solutions to facilitate the decision-making. Results show that the identified key solutions are capable of achieving satisfactory drilling performances with different preferences for exit delamination, surface roughness and material removal rate. This study provides a feasible way to determine the appropriate cutting parameters, with which demands for multiple responses could be satisfied simultaneously in practical machining operations.
Emotional Regulation and Affects in Patients With Borderline Personality Disorder
Authors: Ortiz Geovanny Genaro Reivan , Álvarez Daniel Orlando Icaza 
Published: May 2021

Abstract
Background: The regulation of emotions and affective strategies have been shown to be relevant in the clinic of borderline personality disorder (BPD), however, the studies carried out are still not conclusive on the influencing role of these two variables on the course of the TLP. The need for empirical evidence on the relationship between the internal components of these manifestations is faced: cognitive reappraisal, expressive suppression, positive affect and negative affect. Result: The results indicate that the psychological variables studied present more dysfunctional values ​​in patients with BPD. The symptomatic of BPD does not moderate the relationship between cognitive reappraisal and negative affect; and cognitive reappraisal together with positive affect are associated with fewer BPD symptoms. Conclusion: The results obtained offer different clinical implications in the affective and emotional context of BPD, however, it would be necessary to use alternative measures of the emotional pattern, such as physiological methodologies to have more defining results.
A meta-analysis of gender differences in e-learning outcomes
Authors: yu zhonggen 
Published: May 2021

Abstract
The new century has been witnessing a rapid development of information technologies, along with which e-learning has been increasingly popularized especially in this special pandemic time. This study, including 20 high-quality publications, meta-analytically examined gender differences in e-learning outcomes, e.g. e-learners’ self-efficacy, satisfaction, motivation, attitude, and performance, across the world. The study concludes that there are generally no significant gender differences in e-learning outcomes except in a few countries. For example, females significantly outperformed males in Spain and the UK. In Austria, India, and mixed countries (Chile and Spain), females hold significantly more positive attitudes towards e-learning than males. In the USA, females present significantly higher self-efficacy than males. Future research into the gender issue in e-learning across the world may adopt cross-disciplinary research methods except for a meta-analysis.
Development and Selective Grain Make Plasticity ‘Take the Lead’ in Adaptive Evolution
Authors: USAN MIGUEL BRUN , Rago Alfredo , Thies Christoph , Uller Tobias , Watson Richard A. 
Published: May 2021

Abstract
Background: Biological evolution exhibits an extraordinary capability to adapt organisms to their environments. The explanation for this often takes for granted that random genetic variation produces at least some beneficial phenotypic variation in which natural selection can act. Such genetic evolvability could itself be a product of evolution, but it is widely acknowledged that the immediate selective gains of evolvability are small on short timescales . So how do biological systems come to exhibit such extraordinary capacity to evolve ? One suggestion is that adaptive phenotypic plasticity makes genetic evolution find adaptations faster. However, the need to explain the origin of adaptive plasticity puts genetic evolution back in the driving seat, and genetic evolvability remains unexplained. Results: To better understand the interaction between plasticity and genetic evolvability , we simulate the evolution of phenotypes produced by gene-regulation network-based models of development. First , we show that the phenotypic variation resulting from genetic and environmental perturbation are highly concordant. This is because phenotypic variation, regardless of its cause, occurs within the relatively specific space of possibilities allowed by development. Second, we show that selection for genetic evolvability results in the evolution of adaptive plasticity and vice versa . This linkage is essentially symmetric but, unlike genetic evolvability, the selective gains of plasticity are often substantial on short, including within-lifetime, timescales. Accordingly, we show that selection for phenotypic plasticity can be effective in promoting the evolution of high genetic evolvability. Conclusions: Without overlooking the fact that adaptive plasticity is itself a product of genetic evolution, we show how past selection for plasticity can exercise a disproportionate effect on genetic evolvability and, in turn, influence the course of adaptive evolution.
A Novel Lossless Encoding Algorithm for Data Compression
Authors: Tbakhi Abdelghani , Al-okaily Anas 
Published: May 2021

Abstract
Data compression is a challenging and increasingly important problem. As the amount of data generated daily continues to increase, efficient transmission and storage has never been more critical. In this study, a novel encoding algorithm is proposed, motivated by the compression of DNA data and associated characteristics. The proposed algorithm follows a divide-and-conquer approach by scanning the whole genome, classifying subsequences based on similarity patterns, and binning similar subsequences together. The data are then compressed in each bin independently. This approach is different than the currently known approaches: entropy, dictionary, predictive, or transform based methods. Proof-of-concept performance was evaluated using a benchmark dataset with seventeen genomes ranging in size from kilobytes to gigabytes. The results showed considerable improvement in the compression of each genome, preserving several megabytes compared with state-of-art tools. Moreover, the algorithm can be applied to the compression of other data types include mainly text, numbers, images, audio, and video which are being generated daily and unprecedentedly in massive volumes.
Isoacteoside Attenuates Septic Acute Lung Injury by Inhibiting Inflammation, Oxidative Stress and Endothelial Hyperpermeability in Mice
Authors: Luo Yan-nian , He Nan-nan , Xu Juan , Wang Rui , Cao Wen , Chen Dongdong 
Published: May 2021

Abstract
The present study was aimed to explore the protective role of isoacteoside (ISO) in cecal ligation and puncture (CLP)-induced acute lung injury (ALI) in mice. Mice were divided into the following groups: sham control group, ALI group, and ALI+ISO group, in which mice received 10,50 or 100 mg/kg/day of ISO for 3 days before, 0h and 12h after CLP surgery. In the first experiment, all mice were maintained until 72 h after the CLP operation to calculate the survival rate. In the second experiment, mouse serum and lung and bronchoalveolar lavage fluid (BALF) were collected 24 h after model establishment for detection. The results revealed that ISO significantly improved the ALI associated survival rate, reduced the pathological injury, ALI score, infiltration of inflammatory cells, leakage of cells and proteins into BALF, systemic and local cytokine secretion, and pulmonary oxidative stress. Moreover, ISO significantly inhibited the expression levels of the pro-inflammatory proteins TLR4, MyD88, p-NF-κB p65, p-IKKαβ, and p-IκBα and increased the expression levels of the endothelial permeability related proteins ZO-1, claudin 5 and VE-cadherin. In conclusions, ISO mitigated acute lung injury in mice which was attributed to the capacity of ISO to inhibit inflammation, oxidative stress and endothelial hyperpermeability.
DNASE1L3 Deficiency, New Phenotypes and Evidence for a Transient Type I Interferon Signaling
Authors: Tusseau Maud , Lovšin Ema , Samaille Charlotte , Pescarmona Remi , Maggio Maria Cristina , Selmanovic Velma , Debeljak Marusa , Dachy Angelique , Janin Alexandre , Januel Louis , Mathieu Anne-Laure , Gibier Jean Baptiste , Chopin Emilie , Rouvet Isabelle , Goncalves David , Fabien Nicole , Rice Gillian , Labalme Audrey , Romagnani Paolo , Lesca Gaetan , Walzer Thierry , Viel Sebastien , Perret Magali , Crow Yannick , Avčin Tadej , Cimaz Rolando , Belot Alexandre 
Published: May 2021

Abstract
Deoxyribonuclease 1 like 3 (DNASE1L3) is a secreted enzyme that has been shown to digest the extracellular chromatin derived from apoptotic bodies, and DNASE1L3 pathogenic variants have been associated to a lupus phenotype. It is unclear whether interferon signaling is sustained in DNASE1L3 deficiency in humans. Here we report four new patients carrying biallelic DNASE1L3 pathogenic variations, including two previously unreported mutations. Disease in one patient was characterized by lupus nephritis and skin lesions, while two others exhibited hypocomplementemic urticarial vasculitis syndrome. The fourth patient presented with early-onset inflammatory bowel disease. To explore whether or not the interferon cascade was strongly and sustainably induced, Interferon stimulated genes (ISGs) expression was assessed for each patient. Contrary to canonical type-I interferonopathies, we noticed a transient increase of ISGs in blood, which reverted to normal with disease remission. Reviewing previous reports, DNASE1L3-related disease appears to carry a significant risk of lupus nephritis and a poor outcome together with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). DNASE1L3 deficiency may share the pathogenesis with C1q deficiency by affecting efferocytosis, and this report suggests that interferon production is not directly driven by DNASE1L3 pathogenic variants.