bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjoint-based aerodynamic drag minimisation with trim penalty
Authors: Shitrit S. 
Published: September 2021

AbstractThe aerodynamic performance of conventional aircraft configurations are mainly affected by the wing and horizontal tail. Drag reduction by shape optimisation of the wing, while taking into account the aircraft trimmed constraint, has more benefit than focusing solely on the wing. So in order to evaluate this approach, the following study presents results of a single and multipoint aerodynamic shape optimisation of the wing-body-tail configuration, defined by the Aerodynamic Design Discussion Group (ADODG). Most of the aerodynamic shape optimisation problems published in the last years are focused mainly on the wing as the main driver for performance improvement, with no trim constraint and/or excess drag obtained from the fuselage, fins or other parts. This work partially fills this gap by an investigation of RANS-based aerodynamic optimisation for transonic trimmed flight. Mesh warping and geometry parametrisation is accomplished by fitting the multi-block structured grid to a B-spline volumes and performing the mesh movement by using surface control points embedded within the free-form deformation (FFD) volumes. A gradient-based optimisation algorithm is used with an adjoint method in order to compute the derivatives of the objective and constraint functions with respect to the design variables. In this work the aerodynamic shape optimisation of the CRM wing-body-tail configuration is investigated, including a trim constraint that is satisfied by rotating the horizontal tail. The shape optimisation is driven by 432 design variables that envelope the wing surface, and 120 shape variables for the tail, as well as the angle of attack and tail rotation angles. The constraints are the lift coefficient, wing’s thickness controlled by 1,000 control points, and the wing’s volume. For the untrimmed configuration the drag coefficient is reduced by 5.76%. Optimising the wing with a trim condition by tail rotation results in shock-free design with a considerably improved drag, even better than the untrimmed-optimised case. The second optimisation problem studied is a single and multi-point lift constraint drag minimisation of a gliding configuration wing in transonic viscous flow. The shock is eliminated, reducing the drag of the untrimmed configuration by more than 60%, using 192 design variables. Further robustness is achieved through a multi-point optimisation with more than 45% drag reduction.
Carbon sequestration: counterintuitive feedback of plant growth
Authors: Alonso-Serra Juan 
Published: September 2021

Abstract
Interaction between the atmosphere, plants and soils plays an important role in the carbon cycle. Soils contain vast amounts of carbon, but their capacity to keep it belowground depends on the long-term ecosystem dynamics. Plant growth has the potential of adding or releasing carbon from soil stocks. Since plant growth is also stimulated by higher CO2 levels, understanding its impact on soils becomes crucial for estimating carbon sequestration at the ecosystem level. A recent meta-analysis explored the effect CO2 levels have in plant versus soil carbon sequestration. The integration of 108 experiments performed across different environments revealed that the magnitude of plant growth and the nutrient acquisition strategy result in counterintuitive feedback for soil carbon sequestration.
Novel dual-fluorescent flow cytometric approach for quantification of macrophages infected with Leishmania infantum parasites
Authors: Islek Zeynep , Ucisik Mehmet Hikmet , Sahin Fikrettin 
Published: September 2021

AbstractFlow cytometry analysis emerges as an alternative methodology to microscopy for determination of the Leishmania-infection rates of macrophages. Various flow cytometric approaches have been established for the quantification of Leishmania parasites within host cells, labelled either directly fluorescent dyes or indirectly with fluorescently conjugated antibodies. Although these techniques allow accurate quantification of infection, they fail at detection of non-infected macrophages specifically. This study introduces a new flow cytometric approach for the determination of infection rates of macrophages infected by Leishmania infantum parasites. Prior to infection, J774A.1 macrophages and L. infantum promastigotes were stained separately with PKH26 and PKH67 dyes, respectively. Dual staining enabled detection of each cell type, where non-infected macrophages were also recorded for the quantification. Dual-PKH staining achieved high success in selective staining of promastigotes (99.71%) and macrophages (99.57%). The percentages of parasite-infected macrophages were determined for initial 1:2.5 and 1:10 infection ratios as 15.68 and 61.70%, respectively; indicating significant increase in infection rate parallel to the initial treatment ratio. These results demonstrated that the introduced dual-fluorescence flow cytometric approach can be successfully used as an accurate and rapid quantification method for L. infantum-infected macrophages and strengthens the hypothesis that flow cytometric approaches could replace conventional microscopic methodologies.
Life expectancy, mortality risks and cause of death in patients with serious mental illness in South East London: a comparison between 2008–2012 and 2013–2017
Authors: Chang Chi-Kang , Chesney Edward , Teng Wei-Nung , Hollandt Sam , Pritchard Megan , Shetty Hitesh , Stewart Robert , McGuire Philip , Patel Rashmi 
Published: September 2021

AbstractBackgroundPeople with serious mental illness (SMI) have a significantly shorter life expectancy than the general population. This study investigates whether the mortality rate in this group has changed over the last decade.MethodsUsing Clinical Record Interactive Search software, we extracted data from a large electronic database of patients in South East London. All patients with schizophrenia, schizoaffective disorder or bipolar disorder from 2008 to 2012 and/or 2013 to 2017 were included. Estimates of life expectancy at birth, standardised mortality ratios and causes of death were obtained for each cohort according to diagnosis and gender. Comparisons were made between cohorts and with the general population using data obtained from the UK Office of National Statistics.ResultsIn total, 26 005 patients were included. In men, life expectancy was greater in 2013–2017 (64.9 years; 95% CI 63.6–66.3) than in 2008–2012 (63.2 years; 95% CI 61.5–64.9). Similarly, in women, life expectancy was greater in 2013–2017 (69.1 years; 95% CI 67.5–70.7) than in 2008–2012 (68.1 years; 95% CI 66.2–69.9). The difference with general population life expectancy fell by 0.9 years between cohorts in men, and 0.5 years in women. In the 2013–2017 cohorts, cancer accounted for a similar proportion of deaths as cardiovascular disease.ConclusionsRelative to the general population, life expectancy for people with SMI is still much worse, though it appears to be improving. The increased cancer-related mortality suggests that physical health monitoring should consider including cancer as well.
Self-processing in relation to emotion and reward processing in depression
Authors: Hobbs Catherine , Sui Jie , Kessler David , Munafò Marcus R. , Button Katherine S. 
Published: September 2021

AbstractBackgroundDepression is characterised by a heightened self-focus, which is believed to be associated with differences in emotion and reward processing. However, the precise relationship between these cognitive domains is not well understood. We examined the role of self-reference in emotion and reward processing, separately and in combination, in relation to depression.MethodsAdults experiencing varying levels of depression (n = 144) completed self-report depression measures (PHQ-9, BDI-II). We measured self, emotion and reward processing, separately and in combination, using three cognitive tasks.ResultsWhen self-processing was measured independently of emotion and reward, in a simple associative learning task, there was little association with depression. However, when self and emotion processing occurred in combination in a self-esteem go/no-go task, depression was associated with an increased positive other bias [b = 3.51, 95% confidence interval (CI) 1.24–5.79]. When the self was processed in relation to emotion and reward, in a social evaluation learning task, depression was associated with reduced positive self-biases (b = 0.11, 95% CI 0.05–0.17).ConclusionsDepression was associated with enhanced positive implicit associations with others, and reduced positive learning about the self, culminating in reduced self-favouring biases. However, when self, emotion and reward processing occurred independently there was little evidence of an association with depression. Treatments targeting reduced positive self-biases may provide more sensitive targets for therapeutic intervention and potential biomarkers of treatment responses, allowing the development of more effective interventions.
‘International Shanghai’ (1863–1931): Imperialism and private authority in the Global City
Authors: Cong Wanshu , Mégret Frédéric 
Published: September 2021

AbstractAt the intersection of imperial rule and private power, Shanghai rose to international prominence in the second half of the nineteenth and first half of the twentieth century. It did so by taking advantage of the extraterritorial status and the dynamic, cosmopolitan population of the International Settlement. In evaluating the fate of the Shanghai Municipal Council, we seek to ascertain how private authority could have been constituted on a transnational basis within the framework of a treaty port. The rise of Shanghai was linked to some of the ambiguities of overlapping imperial rule and the possibilities it created for legal and governance experimentation. This is particularly clear in realms most associated with sovereign power, namely the International Settlement’s attempts to claim some taxation power and maintain law and order. That power, however, was interstitial at best and the product of fragile balances, as shown by the Council’s ultimate failure to secure a full international legal status for Shanghai. Nonetheless, the rise and fall of the International Settlement at Shanghai are worth reflecting upon, not only in relation to the history of China, imperialism and international law, but also as a way of thinking how the authority of large metropolitan centres might be constituted.
Retour surLes sons du français:la modernité de Passy
Authors: Durand Jacques , Lyche Chantal 
Published: September 2021

RésuméAu sein de l’enseignement de l’oral, il est souvent difficile de convaincre les didacticiens du français qu’un recours à la phonologie et à la phonétique faisant place à la variation et la diversité des usages est possible et souhaitable. Pourtant, dès la fin du 19èmesiècle, une autre pratique était défendue par des jeunes phonéticiens dont Paul Passy, auteur desSons du français(1887) et coordinateur de la mise en place de l’API. Passy, à cause de ses engagements socio-politiques et religieux, de sa défense souvent mal comprise de l’API et de son combat pour la réforme de l’orthographe, est fréquemment relégué à une place relativement mineure dans l’histoire de la phonétique du français. Nous démontrons ici que les nombreuses révisions desSons du françaisfourmillent de descriptions fines et de remarques sur des changements en cours qui, dans bien des cas, seront redécouverts dans la deuxième partie du 20èmesiècle sans mention de son travail. Nous abordons alors la question de la norme et l’attachement de Passy à la variation et montrons sa modernité à travers son traitement de la prosodie, des unités distinctives, des réalisations allophoniques et de la transcription phonétique.
FREEDOM FROM THINGS: A DEFENSE OF THE DISJUNCTIVE OBLIGATION IN CONTRACT LAW
Authors: Nadler Jennifer 
Published: September 2021

AbstractThis article argues that the disjunctive obligation in contract law can be justified on moral grounds. It argues that from a perspective that regards human beings as free agents capable of choice and therefore independent of material objects, the contracting parties must be understood as agreeing to mutually guarantee one another's ownership of a certain value. This guarantee can be fulfilled either by handing over what was promised or by making up the difference between the market value and the contract value of what was promised. The plaintiff's contractual right is therefore a right that the defendant perform or pay. This makes expectation damages intelligible as a vindication of the plaintiff's contractual right. Moreover, the disjunctive obligation can be reconciled with all the doctrines that others take to be decisive arguments against it—with the doctrines of specific performance, inducing breach, impossibility, preexisting duty consideration, and nominal damages.
The contribution of cognitive behavioural factors to social anxiety in Parkinson’s disease
Authors: Nash Kirsty , Dysch Leon , Todd Jones Jenna , MacQueen Ruth , Marks Elizabeth 
Published: September 2021

AbstractBackground:Social anxiety is prevalent in idiopathic Parkinson’s disease but why this is, is not yet well understood. Social cognitions, safety-seeking behaviours and internally focused attention are all known to predict social anxiety in the general population. These associated factors have not yet been explored in idiopathic Parkinson’s disease, where disease severity and motor symptoms might also influence the experience of social anxiety.Aims:This study aimed to explore the relationship between cognitive behavioural factors and social anxiety in Parkinson’s disease.Method:Using a cross-sectional design, 124 people with Parkinson’s disease completed self-report questionnaires including measures of Parkinson’s disease severity, social anxiety, negative social cognitions, safety-seeking behaviours, internally focused attention, anxiety and depression.Results:The final regression model accounted for 71.6% of variance in social anxiety. Cognitive behavioural variables accounted for the largest magnitude of unique variance (43.5%). Sex, anxiety and depression accounted for 23.4%, and Parkinson non-motor symptom severity for 4.7%. Negative social cognitions and safety-seeking behaviours were statistically significant predictors, while an internal focus of attention was not.Conclusions:Social anxiety in Parkinson’s disease is associated with negative social cognitions and safety-seeking behaviours. Findings indicate the need for further research into cognitive behavioural approaches to social anxiety in Parkinson’s disease.
Atom Probe Study of 1-Octadecanethiol Self-Assembled Monolayers on Platinum (111) and (200) Surfaces
Authors: Solodenko Helena , Stender Patrick , Schmitz Guido 
Published: September 2021

Abstract
Atom probe tomography measurements of self-assembled monolayers of 1-octadecanethiol on platinum tips were performed and their fragmentation behavior under the influence of different laser powers was investigated. The carbon backbone evaporates in the form of small hydrocarbon fragments consisting of one to four carbon atoms, while sulfur evaporates exclusively as single ions. The carbon molecules evaporate at very low fields of 5.9 V/nm, while S requires a considerably higher evaporation field of 23.4 V/nm. With increasing laser power, a weak, but noticeable trend toward larger fragment sizes is observed. No hydrocarbon fragments containing S are detected, indicating that a strong S–Pt bond has formed. The observed surface coverage of S fits well with literature values and is higher for (111)-oriented samples than for (200).
FURTHER DEFENSE OF THE RACIALIZATION CONCEPT
Authors: Hochman Adam 
Published: September 2021

AbstractIn my article, Racialization: A Defense of the Concept, I argue that ‘race’ fails as an analytic category and that we should think in terms of ‘racialization’ and ‘racialized groups’ instead. I define these concepts and defend them against a range of criticisms. In Rethinking Racialization: The Analytical Limits of Racialization, Deniz Uyan critiques my “theory of racialization”. However, I do not defend a theory of racialization; I defend the concept of racialization. I argue that racialization is a useful idea, but I do not advance a theory to explain or predict the phenomena it describes. While Uyan’s critique therefore misses its mark, it raises important questions about the explanatory scope of the racialization concept. Ironically, I may be even more skeptical of the prospects of any general theory of racialization than Uyan. I argue that while we ought to develop theories to explain particular instances of racialization, we should not develop a general theory of racialization, because it is simply too varied in its agents and their intents, the mechanisms through which it operates, and the outcomes it produces. While hope for any general theory of racialisation should be abandoned, I argue that the racialisation concept is still extremely useful. It offers a necessary alternative to race realist concepts, allowing us to point to the wide-ranging effects of belief in race without falsely implying that race itself is real. Uyan does not focus on my arguments against racial realism. However, the theoretical failures and normative risks of racial realism motivate my defense of the racialization concept. In this paper, I reiterate my arguments against racial realism and offer further defense of the concepts of ‘racialization’ and ‘racialized group’.
Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons
Authors: Kelly Jamie M. , Ivatt Peter D. , Evans Mathew J. , Kroll Jesse H. , Hrdina Amy I. H. , Kohale Ishwar N. , White Forest M. , Engelward Bevin P. , Selin Noelle E. 
Published: September 2021

AbstractIn assessments of cancer risk from atmospheric polycyclic aromatic hydrocarbons (PAHs), scientists and regulators rarely consider the complex mixture of emitted compounds and degradation products, and they often represent the entire mixture using a single emitted compound—benzo[a]pyrene. Here, we show that benzo[a]pyrene is a poor indicator of PAH risk distribution and management: nearly 90% of cancer risk worldwide results from other PAHs, including unregulated degradation products of emitted PAHs. We develop and apply a global‐scale atmospheric model and conduct health impact analyses to estimate human cancer risk from 16 PAHs and several of their N‐PAH degradation products. We find that benzo[a]pyrene is a minor contributor to the total cancer risks of PAHs (11%); the remaining risk comes from other directly emitted PAHs (72%) and N‐PAHs (17%). We show that assessment and policy‐making that relies solely on benzo[a]pyrene exposure provides misleading estimates of risk distribution, the importance of chemical processes, and the prospects for risk mitigation. We conclude that researchers and decision‐makers should consider additional PAHs as well as degradation products.
Diversity in the Persistence of El Niño Events Over the Last Millennium
Authors: Sanchez Sara C. , Karnauskas Kristopher B. 
Published: September 2021

AbstractThe El Niño Southern Oscillation (ENSO) is a mode of internal climate variability with far‐reaching impacts. Here, we consider an important aspect of ENSO behavior: the diversity in the persistence of El Niño events. We examine the occurrence of multi‐year El Niño events in instrumental observations, a suite of global climate model simulations of the last millennium, and paleoclimate archives. We find evidence of multi‐year El Niño events in all data sources considered, with a wide range of variability in the frequency of such events across and within the individual sources. Although scarce over the relatively brief satellite era, multi‐year El Niño events are often associated with the warmest El Niño events in observations and most models. Furthermore, we show that multi‐year El Niño events augment the persistence of associated hydroclimate anomalies, which may compound the impacts on vulnerable economies and ecosystems within and beyond the tropical Pacific sector.
120 Years of AMOC Variability Reconstructed From Observations Using the Bernoulli Inverse
Authors: Fraser Neil J. , Cunningham Stuart A. 
Published: September 2021

AbstractDetermining the long‐term nature of the Atlantic Meridional Overturning Circulation (AMOC) presents a major step in understanding ocean temperature forcing, and is crucial both for placing the recently observed AMOC slowdown in the context of climate change and for predicting future climate. We present a time series for AMOC strength over the last 120 years which is derived solely from observations. Application of the Bernoulli inverse to hydrography yields the general geostrophic circulation in the North Atlantic without requiring additional sea surface height information, allowing AMOC evaluation in the pre‐satellite era. AMOC varies on a multidecadal timescale, leading the Atlantic Multidecadal Variability (AMV) in sea surface temperature by 2.5 years. We consider the dynamics of the implied AMOC/AMV coupling, and hypothesize that the low‐frequency variability in both parameters is driven by large‐scale density anomalies circulating in the AMOC.
Surface Deformation and Seismicity Induced by Poroelastic Stress at the Raft River Geothermal Field, Idaho, USA
Authors: Li Bing Q. , Khoshmanesh Mostafa , Avouac Jean‐Philippe 
Published: September 2021

AbstractWe investigate the relative importance of injection and production on the spatial‐temporal distribution of induced seismicity at the Raft River geothermal field. We use time‐series of InSAR measurements to document surface deformation and calibrate a hydro‐mechanical model to estimate effective stress changes imparted by injection and production. Seismicity, located predominantly in the basement, is induced primarily by poroelastic stresses from cold water reinjection into a shallower reservoir. The poroelastic effect of production from a deeper reservoir is minimal and inconsistent with observed seismicity, as is pore‐pressure‐diffusion in the basement and along reactivated faults. We estimate an initial strength excess of ∼20 kPa in the basement and sedimentary cover, but the seismicity rate in the sedimentary cover is four times lower, reflecting lower density of seed‐points for earthquake nucleation. Our modeling workflow could be used to assess the impact of fluid extraction or injection on seismicity and help design or guide operations.
TRIM22 inhibits the proliferation of gastric cancer cells through the Smad2 protein
Authors: Zhou Zhuqing , Gao Wei , Yuan Biao , Zhang Shun , Wang Kaijing , Du Tao 
Published: September 2021

AbstractTRIM22 is involved in tumorigenesis and development, but its mechanism is not clear. In this study, we investigated the expression and biological role of TRIM22 in gastric cancer. We found that TRIM22 mRNA and protein expression was abnormally low in gastric cancer tissues and cells and correlated with tumor size and depth of invasion. Overexpression of TRIM22 significantly inhibited the proliferation, colony formation, and migration of gastric cancer cells and downregulated the expression of HSPA6. However, the HSPA6-siRNA complementation test showed that TRIM22 did not regulate cell proliferation through HSPA6. Furthermore, overexpression of TRIM22 downregulated the phosphorylation of Smad2 and Smad3. In addition, TRIM22 directly binds to Smad2, and overexpression of Smad2 can reverse the inhibition of cell proliferation and migration induced by TRIM22. In vivo, overexpression of TRIM22 significantly inhibited the growth of subcutaneous xenografts in nude mice. Our study indicates that TRIM22 has an important role in the development of gastric cancer and may inhibit the proliferation of gastric cancer cells through Smad2.