bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival outcomes among periviable infants: a systematic review and meta-analysis comparing different income countries and time periods
Authors: Li Ying Xin , Hu Yan Ling , Huang Xi , Li Jie , Li Xia , Shi Ze Yao , Yang Ru , Zhang Xiujuan , Li Yuan , Chen Qiong 
Published: December 2024

BackgroundPeriviable infants are a highly vulnerable neonatal group, and their survival rates are considerably affected by patient-, caregiver-, and institution-level factors, exhibiting wide variability across different income countries and time periods. This study aims to systematically review the literature on the survival rates of periviable infants and compare rates among countries with varied income levels and across different time periods.MethodsComprehensive searches were conducted across MEDLINE, Embase, CENTRAL, and Web of Science. Cohort studies reporting survival outcomes by gestational age (GA) for periviable infants born between 22 + 0 and 25 + 6 weeks of gestation were considered. Paired reviewers independently extracted data and assessed the risk of bias and quality of evidence. Data pooling was achieved using random-effects meta-analyses.ResultsSixty-nine studies from 25 countries were included, covering 56,526 live births and 59,104 neonatal intensive care unit (NICU) admissions. Survival rates for infants born between 22 and 25 weeks of GA ranged from 7% (95% CI 5–10; 22 studies, n = 5,658; low certainty) to 68% (95% CI 63–72; 35 studies, n = 21,897; low certainty) when calculated using live births as the denominator, and from 30% (95% CI 25–36; 31 studies, n = 3,991; very low certainty) to 74% (95% CI 70–77; 48 studies, n = 17,664, very low certainty) for those admitted to NICUs. The survival rates improved over the two decades studied; however, stark contrasts were evident across countries with varying income levels.ConclusionAlthough the survival rates for periviable infants have improved over the past two decades, substantial disparities persist across different economic settings, highlighting global inequalities in perinatal health. Continued research and collaborative efforts are imperative to further improve the global survival and long-term outcomes of periviable infants, especially those in Low- and Middle-Income Countries.Systematic review registrationPROSPERO, CRD42022376367, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022376367.
Suspensão
Authors: Koiky Vanessa , Silva Jofre 
Published: December 2024

Este ensaio propõe a compreensão do design visual como uma disciplina expandida, que dialoga com outros campos do conhecimento para dar espaço a diferentes processos de criação, por meio da abordagem interdisciplinar. A partir dessa premissa, apresenta um recorte e os desdobramentos poéticos iniciais de uma investigação teórico-prática ainda em desenvolvimento no programa de Pós-Graduação em Design da Escola de Belas Artes, da UFRJ. Com base em uma metodologia exploratória, a pesquisa investiga o potencial imagético da fotografia na criação de universos que estimulam a coragem para tentar modos outros de existência, conforme defendido por Michel Foucault. A partir de hibridizações entre produção analógica — fotogramas produzidos em ampliador — e manipulação digital, busca explorar como a combinação de diferentes registros fotográficos, com seus mais diversos significados, podem dar origem a esses registros utópicos. Se pretende, por meio da fotografia, propor um modo outro de viver. Aprofundar a discussão e contribuir para a ampliação das correlações entre os campos da fotografia, design, arte e tecnologia.
Câncer de reto em paciente com síndrome de Lynch submetido a colectomia total prévia - relato de caso impactado pela pandemia por COVID-19
Authors: Cardoso Lucas Alves Bessa , Amaral Hélida Aline Tomacheski , Lacerda Filho Antônio , Santos Marco Antônio Miranda dos , Paiva Rodrigo de Almeida , Silva Pedro Henrique Teodoro 
Published: December 2024

A síndrome de Lynch é uma condição hereditária associada a maior risco de câncer colorretal (CCR) e outros tumores, sendo fundamental o acompanhamento regular para prevenção e diagnóstico precoce. Este relato apresenta o caso de uma paciente de 60 anos com síndrome de Lynch, portadora de mutação no gene MSH-6, previamente submetida a colectomia total por neoplasia sincrônica de cólons, seguida de quimioterapia adjuvante. Durante a pandemia de COVID-19, a paciente interrompeu o seguimento médico devido às restrições impostas, retornando apenas em 2021, quando foi diagnosticada com adenocarcinoma invasivo de reto médio/superior, estádio T3N0. O tratamento consistiu em proctectomia com bolsa ileoanal e ileostomia protetora, além de histerectomia total, sem necessidade de quimioterapia adjuvante. O caso ilustra o impacto negativo da pandemia na vigilância e no tratamento de pacientes com síndromes hereditárias, como a síndrome de Lynch, destacando o atraso no diagnóstico de CCR e suas implicações no prognóstico. Durante a pandemia, houve redução significativa na realização de colonoscopias e no diagnóstico de CCR, associado a aumento de casos emergenciais. Esse relato reforça a necessidade de manter estratégias de vigilância mesmo em cenários adversos para minimizar os efeitos de atrasos no diagnóstico e tratamento oncológico.
Abordaje efectivo de la mastitis granulomatosa idiopática mediante corticoides intralesionales: análisis de casos y revisión bibliográfica
Authors: Elena Zamora Villavicencio María , Francisco Llerena Freire Luis , Izamar Llerena Freire Giannella , Naranjo Juan Luis Acuña , Hidalgo Alisson Mikaela Méndez , Calderón Astrid Janneth Jaramillo , Hidalgo Markos Miguel Yachimba , Franco Erick Hugo Zambrano 
Published: December 2024

Introducción: La mastitis granulomatosa idiopática (MGI) es una enfermedad inflamatoria crónica de la mama que puede resultar debilitante para quienes la padecen. En los últimos años, se han evaluado diversas estrategias terapéuticas, incluyendo la inyección intralesional de esteroides (ILS) y la administración tópica de esteroides. Sin embargo, aún persiste una notable falta de consensos internacionales sobre el manejo óptimo de esta condición. Por ello, se realizó un estudio retrospectivo para analizar la efectividad de la ILS en el tratamiento de la MGI. Método: Se incluyeron en el estudio un total de 61 pacientes diagnosticadas con mastitis granulomatosa idiopática (MGI). Todo el grupo recibió tratamiento únicamente con inyección local de esteroides (ILS). El protocolo para la ILS consistió en administrar inyecciones intralesionales de acetónido de triamcinolonaa una dosis de 25 mg en lesiones identificadas por ecografía cada 15 días. Resultados: Este estudio evaluó la efectividad de las infiltraciones intralesionales de triamcinolona en pacientes con mastitis granulomatosa idiopática (MGI) en un lapso de 2 años. Los resultados post-tratamiento fueron clasificados según el sistema BI-RADS, encontrándose que el 49.18% de las pacientes presentaron resultados benignos BI-RADS 2, lo que indica una alta efectividad del tratamiento. Un 40.98% de las pacientes fueron clasificadas como BI-RADS 3, sugiriendo una respuesta favorable con mínima posibilidad de malignidad. Solo un 9.84% de las pacientes tuvieron resultados de BI-RADS 4A, atribuidos a la presencia de hallazgos de patología mamaria en otros cuadrantes o en la mama contralateral. La edad media de las pacientes fue de 36.3 años, con un promedio de 4.5 infiltraciones por paciente. Se observó una correlación positiva moderada (r = 0.65, p = 0.02) entre el número de infiltraciones y la mejora de los resultados, lo que sugiere que un mayor número de infiltraciones podría estar asociado con mejores resultados post-tratamiento. En cuanto a las complicaciones y recurrencias reportaron porcentajes extremadamente bajos. Conclusión: Los hallazgos sugieren que la inyección intralesional de esteroides es un tratamiento eficaz para la mastitis granulomatosa idiopática, con altas tasas de respuesta completa y un tiempo de respuesta relativamente corto. Asimismo, presenta una menor incidencia de complicaciones y recurrencias en comparación con otros enfoques terapéuticos. No obstante, se requiere de estudios adicionales que incluyan protocolos estandarizados para establecer las mejores prácticas en cuanto a tipo, dosis y frecuencia de las ILS.
Изменения терапии инфекции, вызванной Neisseria gonorrhoeae, за последние 50 лет
Authors: Иштиряков А.В. , Горбунова Т.С. , Платонова П.Я. , Новикова М.Ф. , Тумас А.С. , Сергеева И.Г. 
Published: December 2024

Появление резистентных штаммов N. gonorrhoeae является ключевой проблемой подбора терапии гонококковой инфекции на протяжении многих лет. В статье прослеживается изменение подходов в терапии за последние 50 лет. В качестве основного препарата в 1970-х гг. использовали прокаин-пенициллин G, который уже к 1985 г. был исключен из рекомендаций, с того же момента стали использовать цефалоспорины, дозы которых вплоть до 2024 г. постоянно увеличиваются. На протяжении всего этого времени в качестве альтернативной терапии применяли спектиномицин. Период с середины 1980-х до 2006 г. называют хинолоновым. К концу ХХ в. было известно о штаммах, устойчивых ко многим препаратам, в том числе к ципрофлоксацину, использование которого в 2006 г. было рекомендовано ограничить. Поэтому в «постхинолоновый» период поиск новых схем лечения и применение комбинированной терапии стали вариантами решения проблемы резистентности возбудителя. Кроме того, в настоящее время во многих странах рекомендована двойная терапия – однократное применение цефтриаксона и азитромицина. За последнее десятилетие рассматривается возможность использования препаратов, ранее не рекомендованных для лечения гонококковой инфекции, и разработки новых лекарственных средств.
The emergence of resistant strains of N. Gonorrhoeae, one of the most common sexually transmitted diseases, has been a key problem in the selection of therapy for many years. The article traces the constant change in the treatment of gonorrhea over the last fifty years. Procaine penicillin G was used as the main drug in the 1970s, and by 1985 it was excluded from the recommendations, from the same moment cephalosporins began to be used more actively, the doses of which increased until 2024. Throughout this time, spectinomycin has been used as an alternative therapy. The period from the mid-1980s to 2006 was called quinolone. By the end of the 20th century, it was known about strains resistant to many drugs, including ciprofloxacin, the use of which was recommended to be limited in 2006. Therefore, in the post-quinolone era, the search for new treatment regimens and the use of combination therapy became the right solution to the problem. In addition, dual therapy is currently recommended in many countries – single use of ceftriaxone and azithromycin. Over the past decade, the possibility of using drugs that were not previously recommended for the treatment of gonorrhea and the development of new medicines have been noted.
Прогностическое значение экспрессии CD28 при первичной меланоме хориоидеи
Authors: Жерко И.Ю. , Давыдов Д.А. , Шупилова Е.П. , Могилянчик А.Ф. , Лаврович М.Г. , Портянко А.С. 
Published: December 2024

Цель. Охарактеризовать экспрессию CD28 в иммунном инфильтрате первичной меланомы хориоидеи и определить ее прогностическое значение в отношении выживаемости без прогрессирования и скорректированной выживаемости. Материалы и методы. В исследование включено 67 пациентов с первичной меланомой хориоидеи. Иммуногистохимическим методом изучены уровни и паттерны экспрессии CD28 в тканях опухоли. Проведен регрессионный анализ для выявления независимых факторов прогноза течения заболевания. Результаты. Экспрессия CD28 регистрировалась на мембранах клеток иммунного инфильтрата в 36 (53,7%) случаях. Опухоли с наличием CD28-позитивного иммунного инфильтрата чаще характеризовались неблагоприятными признаками: отсутствием пигмента, фракцией Foxp3-позитивных клеток >0,5, наличием сосудистых арок, соотношением CD3/СD68 более 1. В случае когда содержание CD28-позитивных клеток превышало 1 в поле зрения, риск прогрессирования был выше в 4,9 раза (95% ДИ 1,9–12,5, р<0,001), риск смерти – в 3,1 раза (95% ДИ 1,3–7,2, р=0,008). Заключение. Установлено, что наличие мембранной экспрессии СD28 ассоциировано с увеличением риска прогрессирования заболевания в 4,9 раза, смерти – в 3,1 раза.
Purpose. To examine CD28 expression in the immune infiltrate of primary choroidal melanoma and determine its prognostic value for progression-free survival and adjusted survival. Materials and methods. 67 patients with primary choroidal melanoma were included. The levels and patterns of CD28 expression in tumor tissues were studied using immunohistochemical method. Regression analysis was performed to identify independent factors predicting the course of the disease. Results. CD28 expression was recorded on the membranes of immune infiltrate cells in 36 (53.7%) cases. Tumors with the presence of a CD28-positive immune infiltrate were more often characterized by unfavorable signs: absence of pigment, fraction of Foxp3- positive cells >0.5, presence of vascular arches, CD3/CD68 ratio more than 1. In the case when the content of CD28-positive cells exceeded 1 in the field of view, the risk of progression was 4.9 times higher (95% CI 1.9–12.5, p<0.001), the risk of death was 3.1 times higher (95% CI 1.3–7.2, p=0.008). Conclusion. It was found that the presence of membrane expression of CD28 is associated with an increase in the risk of disease progression by 4.9 times, and death by 3.1 times.
MANAJEMEN SARANA DAN PRASARANA DI SMAQ DARUL FATTAH
Authors: Ngali Zainul , Fisman Bedi  , A. Fauzan  
Published: December 2024

Komponen infrastruktur merupakan bagian dari sistem sekolah dan bagian dari akreditasi sekolah. Kehadiran pengelolaan sarana prasarana membantu dalam terlaksananya pembelajaran di sekolah secara efektif dan efisien. Jenis penelitian yang digunakan adalah deskriptif dan kualitatif, dengan tujuan untuk menyelidiki data informasi terkait prasarana dan ketersediaan serta pemeliharaan prasarana di Sekolah Menengah Atas Quran (SMAQ) Darul Fattah. Subyek yang digunakan dalam penelitian adalah kepala sekolah, pengelola sarana prasarana, pendidik, dan siswa. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Selain itu, peneliti menganalisis data menggunakan prosedur seperti reduksi data, penyajian data, dan inferensi. Analisis kebutuhan dan penilaian mandiri Sekolah Menengah Atas Quran (SMAQ) Darul Fattah menghasilkan fasilitas sebagai berikut: LCD Proyektor di Setiap kelas, papan tulis (whiteboard), AC, Rak/lemari penyimpanan yang luas. Buku, buku teks, bahan ajar. Sarana dan prasarana Sekolah Menengah Atas Quran (SMAQ) Darul Fattah, juga sangat baik karena proses analisis dan evaluasi sarana dan prasarana dipikirkan dengan matang. Seluruh warga sekolah wajib melakukan pekerjaan pemeliharaan untuk menjaga sarana dan prasarana yang tersedia bagi guru dan siswa dalam kondisi baik.
SHAKESPEAREAN PROJECTS IN THE THEATRE HISTORY OF ZHYTOMYR
Authors: Kanchura E. , Vlasyuk K. 
Published: December 2024

The article presents the results of the search, identification, and systematization of Shakespearean projects in the history of Zhytomyr theatre, including original works by Zhytomyr theatres, touring performances, and translations of dramatic texts. This investigation was conducted as part of the large-scale activity of the Ukrainian Shakespeare Centre, which aims to collect and systematize information about the stage representation of William Shakespeare's works in Ukrainian theatres. The research aimed to create a detailed list of Shakespearean performances in Zhytomyr, explore postmodern interpretations related to them, and organize the information for an all-Ukrainian ongoing catalogue of Shakespearean performances.
The authors undertook the following tasks: identifying and comparing sources regarding the theatre history of Zhytomyr, conducting archival and historiographic searches, and interviewing contemporary theatre professionals. These tasks were combined with a deductive method based on the study of facts, particularly to determine the language of the performances.
The research demonstrates that from the very beginning of the history of stationary theatres in Zhytomyr, performances based on Shakespeare’s works have taken place on the city stage. Among the prominent theatre figures who contributed to the formation of Shakespearean discourse in Zhytomyr are A. Żmijowski, J. I. Kraszewski, I. Hołowiński, A. F. Aldridge, I. Kocherga, Boris Ten, V. Humenyuk, V. Martens and P. Avramenko. Plays presented on the Zhytomyr stage include "Hamlet", "Othello", "Titus Andronicus", "The Merchant of Venice", "Romeo and Juliet", "The Winter's Tale", and "A Midsummer Night's Dream". Shakespeare's texts were performed (in chronological order) in Polish, Russian, English, and Ukrainian.
The investigation highlights the role of Shakespeare's texts in introducing the Zhytomyr audience to the context of world classics, reveals the challenges of staging performances during the ideological dictates of the Soviet era, and demonstrates the prospects for modern interpretations of the classics.
Common mistakes in capillaroscopy
Authors: Doncheva-Dilova Jaklin , Stoilov Nikolay , Emin Soner , Boyadzhieva Vladimira 
Published: December 2024

Nail fold capillaroscopy (NFC) is a non-invasive examination and the "gold standard" in rheumatology practice to evaluate the microcirculation and distinguish primary from secondary Raynaud's phenomenon (RP). Alternatives to videocapillaroscopy are USB microscopy, dermatoscopy and ophthalmoscopy. Before the capillaroscopy examination, a detailed general history (including concomitant diseases) and occupational history (including a history of recent trauma to the fingers or onychophagia), a history regarding the patient's hobbies, practicing sports and physical activity, history of taking medications (beta-blockers, vasodilators, anticoagulants, antihypertensives), as well as the use of other vasoactive substances (tobacco, caffeine, cannabis, cocaine, amphetamines) should be taken. A detailed history regarding discoloration of the fingers is necessary to confirm the diagnosis of Raynaud's phenomenon (RP). Capillaroscopic examination should be carried out under certain conditions (not during an attack of RP, after acclimatization, in a certain position of the patient, without consumption of coffee and smoking before the examination, without manicure procedures in the last 15-30 days, examination of all 8 fingers, excluding those with recent trauma and/or infection). Correctly following all these steps will avoid technical errors that can change the interpretation of the result. It is necessary for the examiner to have a good knowledge of the normal capillaroscopic pattern, the variations of the norm in adults, the differences that might be found between children and adults, as well as the different pathological findings and specific patterns ("scleroderma" and "scleroderma-like" type) in diseases occurring with secondary RP. While in rheumatology practice there are defined criteria for "scleroderma" and "scleroderma-like" capillaroscopic finding, the changes in some paraneoplastic, socially significant (AH and DM), occupational (VD) and infectious diseases (Covid-19) occurring with microangiopathy, which can lead to misinterpretation of the finding. The “scleroderma-like” pattern also differs in different rheumatic diseases and the findings can also be misleading. The results of the study must be carefully interpreted with a view to the correct assessment of the patients' condition.
“Treat-to-Target” in Systemic Lupus Erythematosus: Novel Definitions of Remission and Low Disease Activity
Authors: Pencheva Daliya Tsvetanova , Bakalov D. , Boyadzhieva Vladimira , Ivanova Mariana , Stoilov Nikolay 
Published: December 2024

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with alternating periods of activity and remission, where an accurate assessment of disease activity remains crucial for optimal treatment. For this purpose, various instruments and composite measures have been developed to enable objective evaluation and effective patient monitoring. In recent years, the SLE Disease Activity Score (SLE-DAS), validated in 2019, has emerged as a reliable and precise method. It combines 17 clinical and laboratory parameters, offering a more accurate assessment of disease activity. Furthermore, SLE-DAS defines clear criteria for remission and low disease activity, supporting the “treat-to-target” approach. Despite the significance of SLE-DAS, other scales such as the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and its modified versions, Systemic Lupus Activity Measure (SLAM), SLAQ (Systemic Lupus Activity Questionnaire), and the British Isles Lupus Assessment Group (BILAG) Index—continue to be used in clinical practice. Of these, SLEDAI-2K remains the most frequently employed tool in daily rheumatological practice. Despite the variety of tools available, SLE-DAS stands out for its precision, practicality, and wide applicability, both in routine clinical practice and clinical trials, emphasizing its broad utility in managing SLE.
Factor V Leiden mutation in patients with polyarthralgia – case reports and review of literature
Authors: Tanev Dobromir , Robeva R. , Andonova S. , Savov A. 
Published: December 2024

Patients with rheumatological diseases might be at increased risk of venous thromboembolism (VTE) because of inflammation, autoimmune disturbances, prolonged immobilization, and corticosteroid (CS) use. Therefore, more efforts are needed to identify additional prothrombotic factors and provide preventive strategies.
Herein, we presented two cases of young men with polyarthralgia who have undergone unprovoked VTE. The first patient underwent VTE after several intra-articular CS applications, while the other had no concomitant risk factors. The hereditary thrombophilia testing revealed a heterozygous Factor V Leiden (FVL) state in the first patient and homozygous FVL carrier status in the second patient.
Both cases suggest a possible benefit of thrombophilia testing in men under the age of 50 years with polyarthralgia, unprovoked VTE, and impending CS therapy. Estimating the complex thrombotic risk in rheumatological patients before CS use is crucial for preventing thromboses.