bluuebunny/crossref_metadata_2025_split huggingface dataset:
Based on bioinformatics analysis, NF1, BTRC and MAPK14 are the potential biomarkers in the progression of osteoarthritis synovitis
Authors: Yang Mingyi , Su Yani , Ma Yao , Aihaiti Yirixiati , Xu Peng 
Published: March 2021

Abstract
Objective: To study the potential biomarkers and related pathways in osteoarthritis (OA) synovial lesions, and to provide theoretical basis and research directions for the pathogenesis and treatment of OA. Methods: Download the microarray data sets GSE12021 and GSE82107 from Gene Expression Omnibus. GEO2R recognizes differentially expressed genes. Perform functional enrichment analysis of differentially expressed genes and construct protein-protein interaction network. Cytoscape performs module analysis and enrichment analysis of top-level modules. Further identify the Hub gene and perform functional enrichment analysis. TargetScan, miRDB and miRWalk three databases predict the target miRNAs of Hub gene and identify key miRNAs. Results: Finally, 10 Hub genes and 17 key miRNAs related to the progression of OA synovitis were identified. NF1, BTRC and MAPK14 may play a vital role in OA synovial disease. Conclusion: The Hub genes and key miRNAs discovered in this study may be potential biomarkers in the development of OA synovitis, and provide research methods and target basis for the pathogenesis and treatment of OA.
Factors influencing Research Engagement among Medical students in the United Kingdom (REMED-UK): protocol for a prospective, observational, national, multi-centre questionnaire - study
Authors: Osunronbi Temidayo , Adeboye William , Faluyi David , George Jasmine , Sofela Agbolahan 
Published: March 2021

Abstract
Introduction: There has been a decline in the number of academic clinicians in the UK. Also, there are gender and ethnic inequalities in research opportunities amongst UK clinicians. The decision to get involved in research as a clinician is usually made as a medical student. Hence, this study aims to investigate the factors affecting UK medical students’ involvement in research, and to understand their perceptions of research, motivation for and the barriers to their engagement in research.Methods: This study is a prospective, observational, national, multi-centre study that will utilise an online questionnaire using the QualtricsTM survey tool. Medical students that are at least 18 years old and enrolled in a UK medical school in the 2020/21 academic year are eligible to partake in this study. The following data will be collected: demographic, research experience, research perception, research self-efficacy, motivation, and barriers to engaging in research. The outcome measures are: number of research projects, publications, presentations, and successful grant applications.Conclusion: This study will produce evidence-based reports that will guide UK medical schools and relevant organisations in developing resources and programmes that will increase the number of future academic clinicians and resolve inequalities in research opportunities and engagement amongst future clinicians.
In Silico Characterization of Mate Genes in Wheat
Authors: Mohanta Deepika , Debnath Sandip 
Published: March 2021

Abstract
Background: Multidrug and toxic compound extrusion (MATE) genes are a group of multidrug efflux transporters that widely exists in all living organisms and play a major role in the detoxification of heavy metals, metalloids, exogenous xenobiotics and endogenous secondary metabolites out of the cells. However, insilico analysis of MATE gene family in plant species is very limited and thus such analysis need to be elucidated in wheat.Results: We have identified forty-four MATE genes in wheat and categorized into seven families based on their phylogenetic analysis. Further, 43 genes were found to exhibit protein-protein interaction at the protein level by using STRING software. We observed that the maximum number of exons i.e., 14 was identified in genes TraesCS6A02G418800.1 and TraesCS6D02G407900.1. We employed MEME software to find protein motifs associated with the MATE genes where maximum number of motifs were set to 22. Here, the protein motifs among the families 1,2 and 3 were significantly different from the rest. We found that the majority of MATE genes were showing expressions during biotic stress conditions due to disease infestations and the highest level of expression was shown by the gene TraesCS5B02G326600.1 belonging to family 1 which got expressed during Fusarium head blight infestation by Fusarium graminearum after 4 days of inoculation by using Wheat expression browser tool. A total of 39 ternary plots consisting of homoeologous genes for 39 MATE genes, showing different level of expressions during biotic and abiotic stress conditions were composed, where we found 44 % of the triads tend to show non balanced expressions (extreme values) due to their higher tissue- specificity and greater intensity.Conclusion: The results obtained from this study indicated that total 44 MATE genes were found to be directly involved in the metabolism of wheat and were expressed during different biotic and abiotic stress conditions. So such genes can be further evaluated for their interaction with heavy toxic metal elements and sequestration from the cells.
Protocol for a Process Evaluation of an External Pilot Cluster Randomised Controlled Trial of a Theory-Based Intervention to Improve Appropriate Polypharmacy in Older People in Primary Care: The PolyPrime Study
Authors: Rankin Audrey , Molloy Gerard J. , Cadogan Cathal A. , Barry Heather E. , Gorman Ashleigh , Ryan Cristín , Ferrett Alan , McCarthy Pat , Gormley Gerard J. , Fahey Tom , Hughes Carmel 
Published: March 2021

Abstract
Background
The PolyPrime intervention is a theory-based intervention aimed at improving appropriate polypharmacy in older people (aged ≥ 65 years) in primary care. The intervention consists of an online video which demonstrates how general practitioners (GPs) can prescribe appropriate polypharmacy during a consultation with an older patient and a patient recall process, whereby patients are invited to scheduled medication review consultations with GPs. The aim of the process evaluation is to further examine the implementation of the PolyPrime intervention in primary care. This will involve investigating whether the PolyPrime intervention can be delivered as intended across two healthcare systems, how acceptable the intervention is to GPs, practice staff and patients, and to identify the intervention’s likely mechanisms of action.
Methods
The PolyPrime study is an external pilot cluster randomised controlled trial (cRCT) which aims to recruit 12 GP practices across Northern Ireland [NI] (n = 6) and the six counties in the Republic of Ireland (ROI) that border NI (n = 6). Practices have been randomised to intervention or usual care. An embedded process evaluation will assess intervention fidelity (i.e. was the intervention delivered as intended), acceptability of the intervention to GPs, practice staff and patients, and potential mechanisms of action (i.e. what components of the intervention were perceived to be effective). Quantitative data will be collected from data collection forms completed by GPs and practice staff and a feedback questionnaire completed by patients from intervention arm practices, which will be analysed using descriptive statistics. Qualitative data will be collected through semi-structured interviews with GPs and practice staff and audio-recordings of medication review appointments from the intervention arm practices which will be transcribed and analysed using the framework method. Quantitative and qualitative data will be triangulated to provide an overall assessment of intervention fidelity, intervention acceptability and mechanisms of action.
Discussion
This process evaluation will add to feasibility data from the pilot cRCT by providing evidence on the fidelity of implementing the intervention package across two healthcare systems, the acceptability of the intervention and potential mechanisms of action.
Trial registration:
ISRCTN, ISRCTN41009897. Registered 19 November 2019, https://doi.org/10.1186/ISRCTN41009897. Clinicaltrials.gov, NCT04181879. Registered 02 December 2019, https://clinicaltrials.gov/ct2/show/NCT04181879.
Differential effect of statin use on coagulation markers: an active comparative analysis in the NEO study
Authors: Bordbar Mohammadreza , Mutsert Renée de , Cevval Melike , Rosendaal Frits R. , Jukema J. Wouter , Lijfering Willem M. 
Published: March 2021

Abstract
Background: Statins are a potential treatment for venous thromboembolism (VTE) prophylaxis complementary to conventional anticoagulants without associated bleeding complications. The aim of this study was to compare prothrombotic activities of different classes of lipid-lowering drugs in an active comparator design, and determine whether there is a relation between statin versus fibrate/niacin use and procoagulant factor outcomes.Methods: This is a cross-sectional analysis of participants from the Netherlands Epidemiology of Obesity study who were using any class of lipid-lowering drugs, including any types of statins, niacin, and fibrates. We performed linear regression analyses to determine the activity of fibrinogen, factor (F)VIII, FIX, and FXI in statins versus fibrate/niacin users and adjusted for age, sex, tobacco smoking, body mass index (BMI), hypertension, diabetes, and prevalent cardiovascular disease.Results: Among 1043 participants, the mean age was 58.39± 5.19 years, 61% were men, and mean BMI was 31.3± 4.5 kg/m2. Clinical characteristics were balanced between statin and fibrate/niacin users. Statin users had lower mean FVIII (15.8 IU/dL, 95% confidence interval (CI) -0.003 to 31.6), FIX (11.3 IU/dL, 95% CI -0.4 to 23.2) and FXI (18.3 IU/dL, 95% CI 9.4 to 27.3) levels, and higher mean fibrinogen levels (19.1 mg/dL, 95% CI -10.0 to 48.2) compared to fibrate/niacin users.Conclusion: Current statin use was associated with lower plasma levels of FVIII, FIX, FXI, and higher fibrinogen levels compared to fibrate/niacin use. These effects on coagulation factors may, in part, explain the benefit of statin therapy rendered in primary and secondary prevention of VTE.
Hanseatic merchant Heinrijc Hoep (†1466) and his precious book of sermons
Authors: Zwart Cora 
Published: March 2021

Die Staatsbibliothek Preußischer Kulturbesitz zu Berlin, ehemalige Deutsche Staatsbibliothek in Ost-Berlin, besitzt seit dem Jahr 1967 die reich illuminierte, aber bislang eher unbekannte Handschrift eines Predigtbuches (Berlin, SBB-PK, Ms. germ. fol. 1612). Vereinzelte anfängliche kunsthistorische und linguistische Untersuchungen des Manuskripts in den 1980er Jahren haben einige spezifische Eigenschaften des Bandes herausgearbeitet, jedoch nicht den Erstbesitzer oder sein ursprüngliches gesellschaftliches Umfeld ermitteln können. Mutmaßlich soll es sich um einen Einwohner von Utrecht, eine Person, die mit den Brüdern der Devotio Moderna in Verbindung stand oder um eine Person aus den nordöstlichen Niederlanden gehandelt haben.
Dieser Beitrag nimmt erstmals die drei distinktiven Eigenschaften des Manuskripts gemeinsam in den Blick: den Besitzvermerk, die Buchmalereien und die spezifische Sprachvariante. Dadurch gelang es, die ersten Besitzer des Bandes zu identifizieren und ihn überraschenderweise im Umfeld von Hansekaufleuten in den südlichen Niederlanden im 15. Jahrhundert zu situieren.
Thanatomicrobiome – State Of The Art And Future Directions
Authors: Wójcik Joanna , Tomsia Marcin , Drzewiecki Artur , Skowronek Rafał 
Published: March 2021

Abstract
Microbiological studies show that there is a possibility of PMI estimation in reference to presence of typical bacteria and fungi on cadaver or in soil beneath. Microbiome after death (thanatomicrobiome) changes and depends on time since death, temperature, seasons and environment-if human remains are covered, buried, placed in ice or left on the surface. To enlarge current knowledge, some of studies are conducted on animal models with further comparison thanatomicrobiome of different animals-pig, rats-to human cadaver thanatomicrobiome. This study collects different branches of thanatomicrobiome studies as a review to summarize current knowledge.
1. Introduction. 2. Living host microbiome and mycobiome. 3. Diseases-related differences. 4. Thanatomicrobiome – human cadavers studies. 5. Fungi presence – thanatomycobiome. 6. Thanatomicrobiome of frozen cadavers. 7. Soil microbial communities changes. 8. Seasons related microbial changes. 9. Thanatomicrobiome and entomology correlation. 10. Conclusions
“Food-Omics” Applications In The Food Metagenom Profiling
Authors: Juszczuk-Kubiak Edyta , Greguła-Kania Monika , Sokołowska Barbara 
Published: March 2021

Abstract
Modern research in food science and nutrition is transferring from classical methodologies to advanced molecular strategies in which next-generation sequencing (NGS) technology plays a crucial role. In this context, Foodomics has been recently defined as a new and global field using advanced “omics” technologies in food analysis. In recent years, “food-omics” technologies are widely applicated in food microbiology to identify, quantify and to track food microbial consortia in the food chain, as well as in the food safety and quality assessment. Metagenomics, referred to as community genomics is a sequence-based analysis of the collective genomes of microorganisms present in a given environment. This rapidly developing technique has provided new knowledge about taxonomic diversity and the dynamics of microbial communities at the genus, species and even strain level. An comprehensive metagenomic approach has proven to be a powerful tool in profiling the microbial ecology of complex ecosystems such as fermented foods. Currently, research focuses on understanding and controlling the fermentation process to ensure the consistent sensory properties of food products, increase safety and reduce food spoilage. The goal of this review is to provide an overview of the latest achievements of the “food-omics” technologies applied to biodiversity and functionality of food microflora, food safety and quality control. Furthermore, we discuss current challenges and future applications of “food-omics” technologies in the food industry.
1. Introduction. 2. Methodologies and technologies in the field of food-omics. 3. Application of “food-omics” technology in food analysis. 3.1. Metagenomics as a tool for monitoring the fermentation process. 3.2. Monitoring food storage conditions. 3.3. Food safety monitoring. 4. Summary
Risk assessment of possible impacts of climate change and irrigation on wheat yield and quality with a modified CERES-Wheat model
Authors: Liu Jianchao , Yao Wenbin , Jiang Meijun 
Published: March 2021

Abstract
The effects of climate change on yield and quality in different climate regions have high uncertainty. Risk assessment is an effective measure to assess the seriousness of the projected impacts for decision-makers. A modified quality model was used to simulate integrated impacts of climate change, environment, and management on wheat yield and quality. Then, the Canadian Earth System Model version 5 (CanESM5) was used to forecast the daily meteorological data, and the Statistical Downscaling Model (SDSM V5.2) was used for downscaling. The modified CERES-Wheat was combined with the forecasted meteorological data to simulate the future wheat yield and grain protein concentration (GPC). The risk to wheat yield and quality in three climatic regions in Northwest China under two climate change scenarios of the CanESM5 was assessed. The average temperature increased by 0.22–3.34 °C, and precipitation increased by 10–60 mm from 2018 to 2100. Elevated temperature and precipitation had positive effects on the yields. The risk to yield in most regions with climate change decreased by 3.8–25.1%. The risk to GPC in all regions with climate change decreased by 7.3–27.2%. Irrigation decreased the risk to yield greatly but had different effects in the three climatic regions. The risk to yield with irrigation decreased by 37.7–52.1%. In contrast to previous studies, in this study, the risk to GPC with irrigation substantially increased by 25.8–28.9% in humid regions and 3.9–8.8% in subhumid regions and decreased by 37.7–52.1% in semiarid regions. The irrigation should be discreetly applied for different climatic regions to combat climate change.
Modeling and predicting suspended sediment load under climate change conditions: a new hybridization strategy
Authors: Farzin Saeed , Valikhan Anaraki Mahdi 
Published: March 2021

Abstract
In the present study, for the first time, a new strategy based on a combination of the hybrid least-squares support-vector machine (LS-SVM) and flower pollination algorithm (FPA), average 24 general circulation model (GCM) output, and delta change factor method has been developed to achieve the impacts of climate change on runoff and suspended sediment load (SSL) in the Lighvan Basin in the period (2020–2099). Also, the results of modeling were compared to those of LS-SVM and adaptive neuro-fuzzy inference system (ANFIS) methods. The comparison of runoff and SSL modeling results showed that the LS-SVM-FPA algorithm had the best results and the ANFIS algorithm had the worst results. After the acceptable performance of the LS-SVM-FPA algorithm was proved, the algorithm was used to predict runoff and SSL under climate change conditions based on ensemble GCM outputs for periods (2020–2034, 2035–2049, 2070–2084, and 2085–2099) under three scenarios of RCP2.6, RCP4.5, and RCP8.5. The results showed a decrease in the runoff in all periods and scenarios, except for the two near periods under the RCP2.6 scenario for runoff. The predicted runoff and SSL time series also showed that the SSL values were lower than the average observation period, except for 2036–2039 (up to an 8% increase in 2038).
Spectrum of Initial Computed Tomography Findings in RT-PCR Positive Patients with Novel Coronavirus 2019 Disease – A Systematic Review of 2327 Cases
Authors: Gaurav Mishra , Abhilasha Dass , Khatib Mahalaqua Nazli , Zahiruddin Quazi Syed 
Published: March 2021

Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of April 17, 2020, the total number of cases all over the world read as 2,182,823 positive cases with 145,551 deaths and 547,679 recovered cases. In India, the total number of affected cases has alarmingly increased up to 13,430, crossing the 10 thousand mark with 11,214 active cases and 1768 recovered cases. There have been multiple studies and reviews published regarding the nature of the disease, its clinical symptoms and their progression, as well as findings on chest radiography, computed tomography, and positron emission computed tomography.
A systematic literature search of the PubMed database was performed on April 8, 2020, using the suitable keywords and publications on novel coronavirus infection were also searched for in the WHO database. Only those articles published in the year 2020 were included. Data were collected, extracted, and tabulated for systematic reviewing from 26 original articles and 4 case series. The typical radiological findings on computed tomography for COVD 19 were ground-glass opacity with and without consolidation, isolated consolidation, air bronchogram, crazy paving, and interlobular septal thickening with subpleural lines.
With the progression of the disease, other atypical radiological findings are noted, such as pulmonary atelectasis, peribronchial thickening, pleural effusion, pericardial effusion, mediastinal lymphadenopathy, reverse halo or atoll sign, and tree in bud appearance with bronchiectasis. Computed tomography proved as a useful tool for screening COVID 19 cases to delineate the status and severity of lung pathology.
Public Seminar: The Political Economy of Personal Information
Authors: Chen Sibo 
Published: March 2021

(Post on behalf of Dr. Enda Brophy)
There will be a public seminar with Prof. Oscar Gandy before his Smythe lecture on March 24, 2015. The seminar will take place on March 24, 2015 between 3:00 and 5:00 pm at room 2270, Habour Center. Please see the attached poster for details.
PHD Defence: â€œThe Bombing of Air India Flight 182: Demanding Justice, Public Inquiries, and Acts of Citizenshipâ€ by Milan Singh
Authors: Chen Sibo 
Published: March 2021

Our dear colleague, Milan Singh, successfully defended her PHD dissertation on July 30, 2015. Here is the abstract of her dissertation “The Bombing of Air India Flight 182: Demanding Justice, Public Inquiries, and Acts of Citizenship”.
Public Event: David Barsamian on Corporate Media, Alternative media, and Democracy
Authors: Ackerley Christine Rose 
Published: March 2021

(Post on behalf of Prof. Robert Hackett)
There will be a public seminar by David Barsamian, the founder and director of Alternative Radio. The seminar will take place on November 4, 2015, starting at 1.30 p.m. in the CMNS Conference Room K8652 at Burnaby Campus. Please see the attached poster for details.
School of Communication's Graduate Critical Studies Conference
Authors: Ackerley Christine Rose 
Published: March 2021

School of Communication's annual Graduate Critical Studies Conference will take place this Friday, April 29th and Saturday, April 30th at Harbour Centre, Room 2945. The theme this year is "Dialectics of Space: Enclosure and Resistance." The Keynote Lecture will be by David McNally: “Spatial Dialectics: Capital, Enclosure, Emancipation” (Friday April 29th, 2:00-3:15pm, Harbour Centre 2945) To reserve your ticket, register here: https://www.eventbrite.ca/myevent?eid=24942163683 There will also be a Public Lecture by Maurizio Lazzarato, titled “Financialization and War: Race, Class, Gender and Subjectivity” on Friday April 29th, 7:00-9:00pm, Harbour Centre 1800.Faculty, staff, graduate students, undergraduate students, and members of the general public are all encouraged to attend. For more details, please see the program attached.
Reverberations of the Arab Spring: Womenâ€™s Use of Information Technology in Morocco
Authors: Neumark Selena Irene 
Published: March 2021

How are women utilizing the capabilities of Information and Communication Technologies (ICTs) in the service of social and political transformation in the wake of the Arab Spring Uprisings? The structure of information flows on new media platforms have enabled activist groups to gain leverage in political systems and social contexts that otherwise marginalized them and this was never more apparent in the use of ICTs during the Arab Spring. However, Morocco continues to be a largely forgotten hub of revolution as researchers grapple with the systemic shifts observed in countries like Egypt, Libya, and Tunisia. Womenâ€™s rights movements in Morocco exploded in increased action, engagement and influence during the same period, largely by virtue of increased accessibility to and innovative capabilities of ICTs. Moroccoâ€™s movement for womenâ€™s rights and democratisation (gradualist movement) is a lesser-explored context of womenâ€™s heightened engagement since the Arab Spring and hence, the focus of this research. Womenâ€™s use of alternative civic spaces to organize and enact social and political change has resulted in global networks of activism that are changing the climate of the MENA as well as perceptions of it from elsewhere. The region, while often politically turbulent, is also characterized according to a single narrative in the West. The â€œresistance against communal normsâ€ and broadening use of digital media as an extension to existing womenâ€™s voices (Robinson, 2014, p. ii) has helped disseminate critical knowledge on the importance of gender equity to democratic ideals. It has also put an emphasis on womenâ€™s public praxis in Morocco over their religious affiliations or domestic labour.
Keywords: new media, Morocco, activism, communication, technology, social justice