bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordination of Hospitals in the Corona Pandemic
Authors: Neidel Tobias , Heins Jakob , Herrmann Katharina , Martignoni André , Zinsmeister Thomas , Dettmar Roland , Pukelsheim Markus , Brunner Jens O. , Heller Axel R. 
Published: October 2021

Abstract
BackgroundThe second wave of Corona-Pandemic posed the German Healthcare system to a major challenge. Due to the fast and wide spreading of SARS-CoV-2 in November 2020, the number of COVID-19-patients needing intensive care treatment was rapidly growing. Transferring patients between hospitals was necessary to prevent an overflow of treatment capacities within the ambulance district of Augsburg. This project aimed to create a coordination structure that ensures an efficient guiding of all hospitals within the ambulance district Augsburg.Material and methodsAn executive order of the Bavarian ministries of health and internal affairs1 lead to the appointment of a Medical Director of Hospital Coordination (MDHC) within each ambulance district. Each hospital had to nominate a pandemic officer (PO). Based on the executive order and the “disaster management manual 100”2 we established a hospital coordination structure for the ambulance district Augsburg.ResultsBetween October 18th 2020, and February 14th 2021, the staff of the MDHC coordinated 407 transfers of patients. 223 patients were treated on a general ward, 184 on intensive care units. The transfers prevented several impending triage situations. Using the coordination structure, the urgent reduction of a COVID-19 intensive care unit of a level 1 hospital from 7 to 2 beds was managed within 4 hours after alarm. ConclusionsBased on the “disaster management manual 100”2 we were able to establish a hospital coordination structure that can withstand high pressure and ensured that impending triage situations were prevented. Urgent shortages of treatment capacities were balanced through the transfer of patients. The major problem was the lack of intensive care personnel.
Electrocoagulation-Intensified Peroxidation of Poultry Slaughterhouse Wastewater: A Parametric Study and Process Optimization
Authors: Toh Yoke Peng , Bashir Mohammed JK , Guo Xinxin , Wong Lai Peng , Ozturk Dilara , Amr Salem S. Abu , Lim Jun Wei 
Published: October 2021

Abstract
In this research, electrocoagulation intensified peroxidation (ECP) using Aluminium electrode was studied as a post-treatment method for poultry slaughterhouse wastewater (SWW) with 4 operational variables (pH, current density, contact time and H2O2 dosage). Optimization was carried out using Response Surface Methodology (RSM). The experimental data were analyzed via analysis of variance and a second order model was developed to test the effects of process parameters on the treatment performance. The optimum conditions were chosen as; pH 5.83, 0.18 g/L H2O2 dosage, 58.60 min. contact time and current density 4.21 mA/cm2. The compatibility of the predicted optimum conditions has been verified by experimental data. As a result of the experiments performed under optimum conditions, COD, TSS and color removals were found to be 97.89%, 99.31% and 98.56%, respectively. The difference between experimental and predicted values ​​was found to be less than 0.86%. The final treated effluent met the discharge standards determined by the World Bank, EU, US and Malaysian Department of Environment for SWWs. Under optimum conditions to treat 1 cubic meter of SWW was calculated as 2.52 MYR ($ 0.58).
The Comparative Effectiveness of Adult Mosquito Sampling Methods Dealing With Odor-baited Resting Box Traps in a Malaria-endemic Area in Southern Iran
Authors: Kazemi Seyed Hassan Moosa , Salari Yousef , Shahosseini Nariman , Fekri Sajad , Raeisi Ahmad , Khosravani Mousa , Safari Reza , Rafatpanah Azam , Asgarian Tahereh Sadat , Sedaghat Mohammad Mehdi 
Published: October 2021

Abstract
BackgroundIran is under threat of a potential outbreak of mosquito-borne diseases, such as malaria, Dengue fever, Chikungunya, and Zika. The study aimed to determine the efficiency and sustainability of some adult mosquito sampling methods for designing effective entomological surveillance systems in a malaria endemic area.MethodsDifferent rates of tap water, sugar, and yeast (Saccharomyces cerevisiae) were mixed to provide CO2. Anopheles stephensi and Culex pipiens Bandar Abbas strains were reared in the insectary and used for tests. On a lab scale, CO2 orientation experiments were performed using a Y-tube olfactometer on the insectary mosquito strains. In the field trial, human landing catches (HLC), artificial pit shelter (APS), CO2-baited trap (CO2-BT), human and cow odor baited resting boxes (HOBT, COBT), cow urine baited trap (CUBT), and colored un-baited box (UB) were studied in Bandar Abbas, Hormozgan Province, south of Iran. Mean densities of An. stephensi and Cx. pipiens insectary strains, which oriented to CO2 as flowrate of 170, and 300 mL/minute was significantly higher compared to the control group (P < 0.05). The black un-baited inbox resting traps significantly more collected wild mosquito species compared to others colored UB (P ˂ 0.05). ResultsA total of 2722 collected mosquitoes comprises Culex pipiens (48.56%), Anopheles fluviatilis s.l.(14.21%), An. stephensi (11.68%), Cx. theileri (9.95%), Aedes caspius (7.01%), An. dthali (6.79%) An. culicifacies s.l. , An. pulcherrimus, An. sergentii,An. superpictus s.l., Cx. sitiens and, Ae.caspius less than 1%. Anopheles stephensi and, An.sergenti were most collected in CUBT. Anopheles fluviatilis s.l. and Ae. caspius were most found in HLC. Anopheles dthali, Cx. pipiens and, Cx. theileri were most abundant in APS. ConclusionsBlack CUBT and APS methods can be suggested as a perfect sampling strategy for malaria vectors surveillance. APS, and HLC methods were found useful to entomological surveillance systems for arboviral and filarial vector-borne diseases. Further modified sampling methods should be devoted to identify more effective sampling methods.
Multi-scale Oscillation Characteristics and Stability Analysis of Pumped-Storage Unit Under Primary Frequency Governing Condition with Low Water Head Grid-Connected
Authors: Xu Yanhe , Zhao Kunjie , Zhou Jianzhong , Zhang Yongchuan , Liu Wei , Sun Weipeng 
Published: October 2021

Abstract
This paper aims to study the stability of low water head grid-connected primary frequency governing condition (PFGC) of pumped-storage unit (PSU). Firstly, a nonlinear mathematical model of the pumped-storage unit governing system (PSUGS) considering the nonlinear characteristics of water head loss and fifth-order synchronous generator is proposed, and the nonlinear state equation in power control mode is derived. On this basis, the PFGC bifurcation characteristics of the governing system coupled with the first-order and third-order synchronous generator models are explored, and the action mechanism of the excitation characteristics in the nonlinear PSUGS model is proposed in this paper on the nonlinear dynamic response of the system is revealed. Furthermore, the transient characteristics of the nonlinear PSUGS considering the fifth-order synchronous generator model under different water head conditions are studied, the multi-scale oscillation characteristics and stability of the PSUGS under low water head PFGC are analyzed, and the influence laws of hydraulic factors, mechanical factors and electrical factors on the stability of the nonlinear PSUGS are revealed. The results show that under the PFGC, the nonlinear PSUGS meets the supercritical Hopf bifurcation. The high frequency wavelet is excited by the generator excitation system in the PFGC oscillation of the governing system. At the same time, the low-frequency wavelet in the PFGC transient oscillation is mainly caused by the power grid stability and maps with the water hammer effect in the dynamic process. The results of this paper provide a theoretical basis for the stability analysis and optimal governing of low water head PFGC of PSU.
Long-term Drought Reconstruction for Beijing since the Ming Dynasty (1368 - 2019)
Authors: Tang Lingyun , Sangster Heather , Macdonald Neil 
Published: October 2021

Abstract
A greater appreciation of historical sources documenting the weather has been achieved during recent decades, recognising their value in understanding and interpreting long-term climate change, their application and utility for improving climate models and the opportunities they offer for a deeper consideration of societal responses to past climatic events. Using a variety of historical archives, the drought history of Beijing is extended back to 1368, and a new reconstructed instrumental monthly precipitation series presented from 1724-present (2019). This combined instrumental and documentary analysis permits an opportunity to explore past droughts and the inter-relationships between physical, social, and cultural drought impacts. The Standardised Precipitation Index (1724-2019) is augmented with a long-term historical drought classification (1368-2000) based on drought impacts (using a 5-class drought index). Long precipitation reconstruction enables both short- (monthly) and long-term (decadal) drought variability to be robustly assessed for Beijing since the Ming Dynasty, identifying a series of historically severe droughts of comparable severity to recent events, but with a range of varying social and cultural impacts.
Municipal Waste in the European Union: A Data Envelopment Analysis and a Convergence Analysis at the Regional Level
Authors: Chioatto Elisa , Fedele Alberto , Sospiro Paolo 
Published: October 2021

Abstract
Sustainable Waste Management (SWM) is key to achieving a full Circular Economy (CE). Monitoring the transformation path that the European Union (EU) Member States (MSs) are undertaking is, in fact, critical to assessing the impact and effectiveness of recent European waste legislation. Despite several studies have demonstrated positive performance and convergence in the treatement of waste at EU-MS level, efficiency evaluation analysis at regional level is still scant. This research attempts to benchmark Municipal Solid Waste (MSW) management performance of 167 NUTS-2 regions in 20 EU-MSs between 2008-2013, and assess whether is there any positive convergence between EU regions. The efficiency assessment is done with 4 different models of Data Envelopment Analysis (DEA) - Benefit-of-Doubt (BoD), a non-parametric approach. The measurement is presented by the Composite Indicators (CI) which considers the multi-criteria of the main waste treatments. Our results reveal that despite a progressive convergence, still substantial differences in MSW management performances exist between EU-20 regions, even within the same country. Particularly, the analysis demonstrates that best performers are registered in Central and Northern EU NUTS-2 regions, while Eastern and Southern EU NUTS-2 regions performed generally worse.
Occurrence of Eimeria Species (Apicomplexa: Eimeriidae) in Domestic Rabbits (Oryctolagus Cuniculus) in Qena Governorate, Upper Egypt, with a Special Key
Authors: Hussein Nermean Moamen , Rabie Soheir Ahmed , Abuelwafa Wafaa Ade-Eldaiem 
Published: October 2021

Abstract
A total of 200 domestic rabbits were collected from Qena Governorate, Egypt, from October 2018 to October 2020. Their fecal samples were tested for the presence of Eimeria species oocysts using the standard flotation technique, which revealed oocysts in 100 rabbits (50%). The following 11 species of Eimeria were examined morphologically and morphometrically from different parts of the rabbits’ intestine (duodenum, ileum, cecum, colon and rectum): Eimeria coecicola, E. exigua, E. flavescens, E. irresidua, E. magna, E. media, E. perforans, E. intestinalis, E. stiedae, E. vejdovskyi, and E. piriformis. Moreover, the endogenous stages of E. intestinalis were examined by light and transmission electron microscopy. Macrogametogenesis and microgametogenesis were clearly observed. The development of microgamonts, macrogametes, and oocysts with their fine structural characteristics was detected. Additionally, a detailed key for each species is provided according to the common morphological characters such as the presence or absence of oocyst and sporocyst residua as well as conspicuous or inconspicuous micropyle. E. stiedae, E. irresidua, and E. vejdovskyi are reported for the first time in Qena Governorate, Upper Egypt.
Inflammatory Pseudotumor of Omentum Containing Gas Misdiagnosed as Perforation of Hollow Organs
Authors: Nie Shiwen , He Yadong , Zhang Shuo , Cao Fenghong 
Published: October 2021

Abstract
BackgroundInflammatory pseudotumors that grow on the omentum are relatively rare, and inflammatory pseudotumor most often involves the lung. As far as we know, the inflammatory pseudotumor of omentum, which is in the shape of beaded vesicles and contains gas, has never been reported in the literature. Case presentationwe report a 45-year-old Chinese woman who complained of epigastric pain with hematemesis for 9 hours, physical examination showed subxiphoid tenderness, previous history of gastric ulcer and repair of gastric perforation, laboratory examination showed slight increase of white blood cells and decrease of hemoglobin. Computed tomography showed dotted free gas in the abdominal cavity, and the perforation of the hollow organs was considered. The pathological results after emergency operation showed that histiocyte aggregation with multinucleated giant cell reaction could be seen in the omental tissue. Immunohistochemistry :ER (-), PR (-), PAX-8 (-), CK (mesothelial+), MC (mesothelial+), CR (mesothelial+), CD68 (histiocyte+), SMA (smooth muscle+). The abdominal pain was relieved after surgical resection of the tumor, and recovered well after symptomatic treatment.ConclusionInflammatory pseudotumor of omentum containing gas is easily diagnosed as perforation of hollow organs, with few clinical manifestations of acute abdomen, mostly non-specific, and a good prognosis. Understanding its clinicopathological features and pathological examination methods are helpful to diagnose the disease, so as to choose an appropriate treatment plan, and whether surgical treatment is better than conservative treatment remains to be further studied. The disease should be distinguished from perforation of hollow organs, but the source of gas is unknown. It may have something to do with past medical history.
Same Age, Different Patient Generation: Aging With Severe Mental Illness With First Admission Pre- or Post the Deinstitutionalization of Psychiatric Care in Sweden
Authors: Bülow Pia H. , Finkel Deborah , Wilinska Monika , Torgé Cristina Joy , Jegermalm Magnus , Bravell Marie Ernsth , Bülow Per 
Published: October 2021

Abstract
Background: The concept of deinstitutionalization started in the 1960s in the US to describe closing down or reducing the number of beds in mental hospitals. The same process has been going on in many countries but with different names and in various forms. In Europe, countries like Italy prescribed by law an immediate ban on admitting patients to mental hospitals while in some other European countries psychiatric care was reorganized into a sectorized psychiatry characterized by open psychiatric care. This sectorization has not been studied to the same extent as the radical closures of mental hospitals, even though it entailed major changes organization of care. The deinstitutionalization in Sweden is connected to the sectorization of psychiatric care, a protracted process taking years to implement. Methods: Older people, with their first admission to psychiatric care before or after the sectorization process, were followed using three different time metrics: (a) year of first entry into a mental hospital, (b) total accumulated time of inpatient care, and (c) changes resulting from aging. Data from surveys in 1996, 2001, 2006, and 2011 were used, together with National registers. Results: Examination of date of first institutionalization and length of stay indicates a clear break in 1985, the year when the sectorization was completed in the studied municipality. The results show that the two groups, despite belonging to the same age group (birthyears 1910 – 1951, mean birthyear 1937), represented two different patient generations. The pre-sectorization group was institutionalized at an earlier age and accumulated more time in institutions than the post-sectorization group. Compared to the post-sectorization group, the pre-sectorization group were found to be disadvantaged in that their level of functioning was lower, and they had more unmet needs, even when diagnosis was taken into account.Conclusions: Sectorization is an important divide which explains differences in two groups of the same age but with different institutional history: “younger” and “older” patient generations that received radically different types of care. The results indicate that the sectorization of psychiatric care might be as important as the Mental Health Care Reform of 1995, although a relatively quiet revolution.
Roles of Fas/FasL and Complement Activation in Adult Patients With Chronic Active Epstein-Barr Virus Hepatitis
Authors: Lin Jing , Su Miaofang , Zheng Jiaolong , Wu Haicong , Gu Lei , Wu Xia , Lin Haiyan , Liu Bang , Wu Zhixian , Li Dongliang 
Published: October 2021

Abstract
Background: Chronic active Epstein-Barr virus hepatitis (CAEBVH) in adult patients is a rare and highly lethal disease characterized by hepatitis and hepatomegaly.Aims: To investigate the clinicopathological features and pathogenic mechanisms in patients with CAEBVH.Methods:10 adult patients confirmed CAEBVH infection were collected. The clinicopathological characteristics were summarized and analyzed by clinical data. Flow cytometry to detect peripheral blood immune cell phenotypes, second-generation sequencing methods to explore pathogenic mechanisms, and immunohistochemical methods to verify pathogenic mechanisms.Results: The clinical features included splenomegaly, hepatomegaly, abnormal liver function, and CD8+T lymphopenia. HE also showed lymphocytic infiltration in liver tissue. EBER-ISH in lymphocytes of liver tissues were positive. Whole exon sequencing showed mutant genes were primarily enriched in 'T cell activation' and 'Complement and coagulation cascades'. The expression of CD8 in the CAEBVH group was higher than the controls in liver tissue (p<0.05). The same as the expression of Fas, FasL, Caspase-8, and TUNEL assay (p<0.05). Complement 1q (C1q) of liver sinusoidal endothelial cells (LSECs) and Glisson's capsule (GC), as well as Complement 3d (C3d) of LSECs, were a higher expression in CAEBV infection than controls (p<0.05).Conclusion: Fas/FasL and complement activation were involved in adult patients with chronic active Epstein-Barr virus hepatitis.
Droplet Motion on Sonically Excited Hydrophobic Meshes
Authors: Abubakar Abba Abdulhamid , Yilbas Bekir Sami , Al-Qahtani Hussain , Alzaydi Ammar 
Published: October 2021

Abstract
The sonic excitation of the liquid droplet on a hydrophobic mesh surface gives rise to a different oscillation behavior than that of the flat hydrophobic surface having the same contact angle. To assess the droplet oscillatory behavior over the hydrophobic mesh, the droplet motion is examined under the external sonic excitations for various mesh screen aperture ratios. An experiment is carried out and the droplet motion is recorded by a high-speed facility. The findings revealed that increasing sonic excitation frequencies enhance the droplet maximum displacement in vertical and horizontal planes; however, the vertical displacements remain larger than those of the horizontal displacements. The resonance frequency measured agrees well with the predictions and the excitation frequency at 105 Hz results in a droplet oscillation mode (n) of 4. The maximum displacement of the droplet surface remains larger for the flat hydrophobic surface than that of the mesh surface with the same contact angle. In addition, the damping factor is considerably influenced by the sonic excitation frequencies; hence, increasing sonic frequency enhances the damping factor, which becomes more apparent for the large mesh screen aperture ratios. The small-amplitude surface tension waves create ripples on the droplet surface.
MESP2 Binds Competitively To TCF4 to Suppress Gastric Cancer Progression By Regulating The SKP2/p27 Axis
Authors: Ge Lingjun , Zhao Gaichao , Lan Chao , Tan Ruoyue , Geng Shengjun , Wang Feng , Huang Pan , Tang Houyi , Lü Muhan , Cui Hongjuan 
Published: October 2021

Abstract
Background: Gastric cancer (GC) is a major cause of human deaths worldwide, and is notorious for its high incidence and mortality rates. Mesoderm Posterior Basic Helix-loop-helix (bHLH) transcription factor 2 (MESP2) acts as a transcription factor with a conserved bHLH domain. However, whether MESP2 contributes to tumorigenesis and its potential molecular mechanisms, remain unexplored.Methods: Immunohistochemistry was used to examine MESP2 expression in clinical gastric tissues. In vitro cell proliferation, migration, and invasion assays were used to investigate the effects of MESP2 on gastric cells progress. Expression microarray profiling，co-immunoprecipitation and chromatin immunoprecipitation were used to explore the potential molecular mechanisms of MESP2 on tumorigenesis. Subcutaneous tumor formation and orthotopic implantation assays were performed in NOD/SCID mice to confirm the effects of MESP2 on gastric growth and metastasis in vivo. Results: Noticeably, MESP2 expression levels are decreased in GC tissues and cell lines compared to those in normal tissue. Further, in vitro and in vivo experiments have confirmed that MESP2 overexpression suppresses GC cell growth, migration, and invasion, whereas MESP2 knockdown results in the exact opposite. In addition, MESP2 binds to transcription factor 7-like 2 (TCF7L2/TCF4) to inhibit the activation of the TCF4/beta-catenin transcriptional complex, decrease the occupancy of the complex on the S-phase kinase Associated Protein 2 (SKP2) promoter, and promote p27 accumulation. MESP2 knockdown facilitated tumorigenesis, which was partially suppressed by SKP2 knockdown. Conclusions: Our findings demonstrate that MESP2 binds competitively to TCF4 to suppress GC progression by regulating the SKP2/p27 axis, thus offering a potential therapeutic strategy for future treatment.