bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entzündliche Veränderungen des Hüftgelenks
Authors: Weidekamm Claudia , Teh James 
Published: February 2021

ZusammenfassungDie Osteoarthrose ist die häufigste Ursache für den Hüftschmerz des Erwachsenen. Daher wird anderen Ursachen wie z. B. Entzündungen weniger Beachtung für den Gelenkschmerz in der Erstdiagnose geschenkt. Dieser Artikel gibt eine Übersicht von unterschiedlichen rheumatologischen Erkrankungen der Hüfte und deren Interpretation in der Bildgebung. Die Vor- und Nachteile der einzelnen bildgebenden Verfahren werden anhand der pathologischen Befunde für die rheumatologischen Erkrankungen erläutert.
Evaluating Non-Market Values of Agroecological and Socio-Cultural Benefits of Diversified Cropping Systems
Authors: Latvala Terhi , Regina Kristiina , Lehtonen Heikki 
Published: February 2021

AbstractWe explored how consumers value the ecological and socio-cultural benefits of diversified food production systems in Finland. We used a stated preference method and contingent valuation to quantify consumers’ willingness to pay (WTP) for the benefits of increased farm and regional scale diversity of cultivation practices and crop rotations. Three valuation scenarios were presented to a representative sample of consumers: the first one focused on agroecosystem services on cropland, the second on wider socio-cultural effects and the third was a combination of them. The results suggest that consumers are willing to pay on the average €228 per household annually for the suggested diversification. This is equal to €245 per hectare of cultivated cropland. The results also indicate that 21% of consumers were not willing to pay anything to support more diverse cropping systems. The relatively high WTP for both agroecological and socio-cultural benefits provide important messages for actors in the food chain and for policy makers on future targeting of economic resources within agri-environmental schemes.
Studying Enhanced Recovery After Surgery (ERAS®) Core Items in Colorectal Surgery: A Causal Model with Latent Variables
Authors: Gemma Marco , Pennoni Fulvia , Braga Marco 
Published: February 2021

AbstractBackgroundPrevious Enhanced Recovery After Surgery (ERAS®) studies have not always taken into account that ERAS interventions depend on baseline covariates and that several confounding variables affect the composite outcomes.MethodA causal latent variable model is proposed to analyze data obtained prospectively concerning 1261 patients undergoing elective colorectal surgery within the ERAS protocol. Primary outcomes (composite of any complication, surgical site infection, medical complications, early ready for discharge (TRD), early actual discharge) and secondary outcomes (composite of late bowel function recovery, IV fluid resumption, nasogastric tube replacement, postoperative nausea and vomiting, re‐intervention, re‐admission, death) are considered along with their multiple dimensions.ResultsConcerning the primary outcomes, our results evidence three subpopulations of patients: one with probable good outcome, one with possibly prolonged TRD and discharge without complications, and the other one with probable complications and prolonged TRD and discharge. Epidural anesthesia, waiving surgical drainage, and early ambulation, IV fluid stop and urinary catheter removal act favorably, while preoperative hospital stay and blood transfusion act negatively. Concerning the secondary outcomes our results evidence two subpopulations of patients: one with high probability of good outcome and one with high probability of complications. Epidural anesthesia, waiving surgical drainage, early ambulation and IV fluid stop act favorably, while blood transfusion acts negatively also with respect to these secondary outcomes.ConclusionThe multivariate causal latent class two‐parameter logistic model, a modern statistical method overcoming drawbacks of traditional models to estimate the average causal effects on the treated, allows us to disentangle subpopulations of patients and to evaluate ERAS interventions.
Klima – Daten – Kunst
Authors: Schneider Birgit 
Published: February 2021

ZusammenfassungDer Klimawandel, verstanden als ein statistisches Objekt aus Zahlen, ist unsichtbar. Auch Temperaturen, Luftdruck oder CO2 lassen sich nicht mit bloßem Auge sehen. Der Beitrag thematisiert Arbeiten von KünstlerInnen wie Eve Mosher, HeHe, Robin Price und Nathalie Miebach, die atmosphärische Daten zur Grundlage haben. Das Potential der Kunst ist es, abstrakte Daten begreifbar zu machen und in ästhetische Situationen zu überführen. Die Künstlerinnen und Künstler verwandeln die wissenschaftlichen Daten in alternative Wahrnehmungsformen wie Lichtinstallationen oder Datenskulpturen, so dass die unsichtbaren oder nur schwer greifbaren Phänomene Klimawandel oder Luftverschmutzung auf neue Weise erfahrbar und vorstellbar werden. Derartige Ansätze sind Teil einer ökologisch motivierten Ästhetik. Sie nutzen das Potential der Kunst, das Wahrnehmungsproblem des Klimawandels zu überwinden. Gleichzeitig stehen die Werke in der kunsthistorischen Tradition einer programmierten Ästhetik und in der Geschichte der Datenvisualisierung, worauf der Artikel ebenfalls eingeht.
Reaktionsmuster der lokoregionären Lymphknoten im Abflussgebiet von COVID-19-Lungen
Authors: Haslbauer Jasmin D. , Matter Matthias S. , Stalder Anna K. , Tzankov Alexandar 
Published: February 2021

Zusammenfassung
Hintergrund
Eine dysregulierte Immunantwort, z. B. in der Form eines Zytokinsturmes, einer Störung des Immunglobulinklassenwechsels, eines sog. antikörpervermitteltem Enhancements oder einer aberranten Antigenpräsentation wurde bereits in schweren Krankheitsverläufen von COVID-19 beschrieben.

Ziel der Arbeit
Zur Charakterisierung der COVID-19-Immunantwort wurde die Histomorphologie der Lymphknoten des pulmonalen Abflussgebietes untersucht.

Material und Methoden
Regionale Lymphknoten des pulmonalen Abflussgebiets wurden bei COVID-19-Autopsien asserviert (n = 20). Deren Histomorphologie, SARS-CoV-2-qRT-PCR sowie Genexpressionsanalysen von gängigen Genen der Immunantwort wurden berücksichtigt.

Ergebnisse
Histologisch zeigten sich ein mäßig- bis schwergradiges Ödem mit Kapillarostase, eine erhöhte Anzahl von extrafollikulären Plasmablasten, milde bis mäßige Plasmazytose, vermehrte CD8+-T-Zellen und CD11c/CD68+-Histiozyten mit Hämophagozytoseaktivität. Von 20 Fällen wiesen 18 hypoplastische oder fehlende Keimzentren sowie eine Verminderung der follikulären dendritischen Zellen und follikulären T‑Helferzellen auf. In 14 von 20 Fällen war der qRT-PCR-Nachweis von SARS-CoV‑2 positiv, jedoch zeigte sich nur bei einem einzigen Fall eine immunhistochemische Positivität für SARS-CoV-2-N-Antigene in Sinushistiozyten. In Genexpressionsanalysen war eine erhöhte Expression von STAT1, CD163, Granzym B, CD8A, MZB1 und PAK1, neben CXCL9 zu beobachten.

Diskussion
Die Befunde in den Lymphknoten deuten auf eine dysregulierte Immunantwort bei schweren COVID-19-Krankheitsverläufen hin. Insbesondere impliziert das Ausbleiben der Keimzentrumsreaktion und die vermehrte Präsenz von Plasmablasten eine nur transiente B‑Zellreaktion, welche die Entwicklung einer Langzeitimmunität infrage stellt.
Antarctic krill (Euphausia superba) exhibit positive phototaxis to white LED light
Authors: Krafft Bjørn A. , Krag Ludvig A. 
Published: February 2021

AbstractThe use of light-emitting diodes (LEDs) is increasingly used in fishing gears and its application is known to trigger negative or positive phototaxis (i.e., swimming away or toward the light source, respectively) for some marine species. However, our understanding of how artificial light influences behavior is poorly understood for many species and most studies can be characterized as trial and error experiments. In this study, we tested whether exposure to white LED light could initiate a phototactic response in Antarctic krill (Euphausia superba). Trawl-caught krill were used in a controlled artificial light exposure experiment conducted onboard a vessel in the Southern Ocean. The experiment was conducted in chambers with dark and light zones in which krill could move freely. Results showed that krill displayed a significant positive phototaxis. Understanding this behavioral response is relevant to development of krill fishing technology to improve scientific sampling gear, improve harvest efficiency, and reduce potential unwanted bycatch.
Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter
Authors: Picon Carmen , Jayaraman Anusha , James Rachel , Beck Catriona , Gallego Patricia , Witte Maarten E. , van Horssen Jack , Mazarakis Nicholas D. , Reynolds Richard 
Published: February 2021

AbstractSustained exposure to pro-inflammatory cytokines in the leptomeninges is thought to play a major role in the pathogenetic mechanisms leading to cortical pathology in multiple sclerosis (MS). Although the molecular mechanisms underlying neurodegeneration in the grey matter remain unclear, several lines of evidence suggest a prominent role for tumour necrosis factor (TNF). Using cortical grey matter tissue blocks from post-mortem brains from 28 secondary progressive MS subjects and ten non-neurological controls, we describe an increase in expression of multiple steps in the TNF/TNF receptor 1 signaling pathway leading to necroptosis, including the key proteins TNFR1, FADD, RIPK1, RIPK3 and MLKL. Activation of this pathway was indicated by the phosphorylation of RIPK3 and MLKL and the formation of protein oligomers characteristic of necrosomes. In contrast, caspase-8 dependent apoptotic signaling was decreased. Upregulation of necroptotic signaling occurred predominantly in macroneurons in cortical layers II–III, with little expression in other cell types. The presence of activated necroptotic proteins in neurons was increased in MS cases with prominent meningeal inflammation, with a 30-fold increase in phosphoMLKL+ neurons in layers I–III. The density of phosphoMLKL+ neurons correlated inversely with age at death, age at progression and disease duration. In vivo induction of chronically elevated TNF and INFγ levels in the CSF in a rat model via lentiviral transduction in the meninges, triggered inflammation and neurodegeneration in the underlying cortical grey matter that was associated with increased neuronal expression of TNFR1 and activated necroptotic signaling proteins. Exposure of cultured primary rat cortical neurons to TNF induced necroptosis when apoptosis was inhibited. Our data suggest that neurons in the MS cortex are dying via TNF/TNFR1 stimulated necroptosis rather than apoptosis, possibly initiated in part by chronic meningeal inflammation. Neuronal necroptosis represents a pathogenetic mechanism that is amenable to therapeutic intervention at several points in the signaling pathway.
Does the osteon morphology depend on the body mass? A scaling study on macroscopic and histomorphometric differences between cow (Bos taurus) and sheep (Ovis aries)
Authors: Zedda Marco , Babosova Ramona 
Published: February 2021

AbstractThe structure and geometry of bone depend on many biological and environmental factors. These factors affect the bone tissue's microstructure differently, and their interaction has not yet been fully elucidated. Our research investigated the effect of body mass on the macro- and microstructure of the compact bone. Therefore we analyzed the humerus and femur bones from females of 11 cows and 11 sheep at the age of 4–10 years. Both species have very similar dietary and locomotion patterns, but their body size and weight are very different. Within macroscopical analyzes of bones were observed ascending order of robustness index and bone diaphysis index. In both animals, plexiform and irregular Haversian bone tissues were identified in humerus and femur. Conversely, the dense Haversian tissue present only in cow above all in the femur. The most considerable interspecific osteonal difference between sheep and cow was in the osteon density, whose average value is 37% higher in the cow. The osteons of sheep humerus are almost circular, and osteons of cow femur are more elliptical. Within both species, the femoral osteons are elliptical than those of humerus. Despite the cow weighing more than 10 times the sheep, the measurements of osteons and Haversian canals, are very similar (the values of the ratio cow/sheep for these types are comprised from 1.04 to 1.86). Our findings indicate that the body mass does not affect the size of bone microstructure, probably more sensitive to other factors as a lifestyle and locomotor ability.
Genetic analysis of medfly populations in an area of sterile insect technique applications
Authors: Sancho Rubén , Guillem-Amat Ana , López-Errasquín Elena , Sánchez Lucas , Ortego Félix , Hernández-Crespo Pedro 
Published: February 2021

AbstractThe sterile insect technique (SIT) is widely used in integrated pest management programs for the control of the Mediterranean fruit fly (medfly),Ceratitis capitata. The genetic interactions between the released individuals from the genetic sexing strains (GSS), used for SIT applications worldwide, and wild individuals have not been studied. Under the hypothesis that a number of Vienna GSS individuals released to the field might not be completely sterile and may produce viable offspring, we have analyzed medfly Spanish field populations to evaluate the presence of Vienna strain genetic markers. To this goal, we have used contrasted nuclear and mitochondrial genetic markers, and two novel sets of nuclear polymorphisms with the potential to be markers to discriminate between Vienna and wild individuals. Nuclear Vienna markers located on the 5th chromosome of Vienna males have been found in 2.2% (19 from 875) of the Spanish wild medfly females captured at the area where SIT is applied. In addition, a female-inherited mitochondrial Vienna marker has been found in two from the 19 females showing nuclear Vienna markers. The detection of several of these markers in single individuals represents evidence of the introgression of Vienna strain into natural populations. However, alternative explanations as their presence at low frequency in wild populations in the studied areas cannot be fully discarded. The undesired release of non-fully sterile irradiated GSS individuals into the field and their interactions with wild flies, and the potential environmental implications should be taken into account in the application of the SIT.
The use of health apps in primary care—results from a survey amongst general practitioners in Germany
Authors: Wangler Julian , Jansky Michael 
Published: February 2021

SummaryMass availability and use of health apps raises the question as to how they might be integrated into healthcare systems towards improving prevention and therapy. This study has researched prevailing opinion on health apps amongst primary care physicians, potential application areas physicians have seen in their experience with these apps up to now, and situations suitable for using apps in patient care. A total of 2138 primary care physicians in the state of Baden-Württemberg, Germany, responded to an anonymised written survey between March and June 2020. Physicians with a positive opinion (36%) emphasised motivation and compliance as advantages, whereas sceptical respondents (43%) expressed suspicion regarding data privacy and reliability as well as legal issues and additional workload arising from using the apps. Even so, a clear majority accepted the potential benefit from sensible use of health apps with features providing prevention and lifestyle support (90/76%). With respect to patients using the apps, 54% of respondents saw a positive contribution to healthcare and/or recovery. Despite the perceived benefits of health apps, general practitioners are still reluctant to bring up or recommend health apps in their consultations. Many physicians do not feel capable of giving expert advice to patients on the apps available. Many general practitioners are aware of the potential that health apps may have in improving prevention and treatment. However, there are reservations and uncertainties regarding clarity, transparency, and privacy issues in these apps. More focus should be placed on these concerns to ensure ideal conditions for integrating health apps into primary care.
From micro to nano: polypropylene composites reinforced with TEMPO-oxidised cellulose of different fibre widths
Authors: Gaduan Andre N. , Solhi Laleh , Kontturi Eero , Lee Koon-Yang 
Published: February 2021

AbstractTEMPO-oxidised cellulose fibres are often explored as nano-reinforcement for polymers. However, it is unclear whether micrometre-sized TEMPO-oxidised cellulose fibres also possess similar reinforcing potential. In this work, we report the mechanical response of polypropylene (PP) composites reinforced with TEMPO-oxidised cellulose (TOC) of different fibre widths. Micrometre-sized TOC fibres (TOCF) containing sodium carboxylate (TOCF-Na) and free hydroxyl (TOCF-H) groups, as well as nano-sized TOC nanofibrils (TOCN) were produced from dissolving pulp and incorporated into PP matrix via melt-extrusion. It was found that model PP composites containing micrometre-sized TOCF-Na and TOCF-H possessed the highest tensile modulus of up to 2.5 GPa; 40% improvement over neat PP and 30% increase over PP/TOCN composite. No significant differences in the tensile strength of PP/TOCF-Na and PP/TOCF-H composites were observed when compared to neat PP. The incorporation of nano-sized TOCN into PP however, led to a 6% decrease in tensile strength. Single-edge notched beam fracture toughness test further showed that PP/TOCN composite possessed the lowest fracture toughness of 2.52 MPa m1/2; a decrease of 18% over PP reinforced with micrometre-sized TOCF-Na and TOCF-H. Our study shows that micrometre-sized TOCFs serve as better reinforcement for polymers compared to nano-sized TOCN. This is attributed to the better dispersion of TOCF in the PP matrix. Furthermore, the presence of surface microfibrillation on TOCFs also enhanced the quality of the TOCF-PP interface through mechanical interlocking and local stiffening of the PP matrix.
Updated and outdated reservations about research into stratospheric aerosol injection
Authors: Smith Wake , Henly Claire 
Published: February 2021

AbstractIn this paper, we seek to ground discussions of the governance of stratospheric aerosol injection research in recent literature about the field including an updated understanding of the technology’s deployment logistics and scale, pattern of effects, and research pathways. Relying upon this literature, we evaluate several common reservations regarding the governance of pre-deployment research and testing including covert deployment, technological lock-in, weaponization, slippery slope, and the blurry line between research and deployment. We conclude that these reservations are no longer supported by literature. However, we do not argue that there is no reason for concern. Instead, we enumerate alternative bases for caution about research into stratospheric aerosol injection which are supported by an up-to-date understanding of the literature. We conclude that in order to establish the correct degree and type of governance for stratospheric aerosol injection research, the research community must focus its attention on these well-grounded reservations. However, while these reservations are supported and warrant further attention, we conclude that none currently justifies restrictive governance of early-stage stratospheric aerosol injection research.
The political economy of euro area sovereign debt restructuring
Authors: Heinemann Friedrich 
Published: February 2021

AbstractThe establishment of a sovereign debt restructuring mechanism (SDRM) is one of the important issues in the academic debate on a viable constitution for the European Monetary Union (EMU). Yet the topic seems to be taboo in official reform contributions to the debate. Against this backdrop, the article identifies the SDRM interests of key players, including the European Commission, the European Parliament, the European Central Bank and national governments. The empirical section takes advantage of the recently established EMU Positions Database. The findings confirm political economy expectations: Low-debt countries support an EMU constitution that includes an insolvency procedure whereas a coalition of high-debt countries and European institutions oppose it. The analysis points towards a possible political-economic equilibrium for coping with sovereign insolvencies: an institutional set-up without an SDRM and with hidden transfers. Recent European fiscal innovations in response to the Covid-19 solvency shock confirm this prediction.
Genetic loci regulating cadmium content in rice grains
Authors: Norton Gareth J. , Travis Anthony , Ruang-areerate Panthita , Nicol Graeme W. , Adeosun Ayotunde A. , Hossain Mahmud , Islam M. Rafiq , Douglas Alex , Price Adam H. 
Published: February 2021

AbstractIt has been estimated that up to 90% of human exposure to cadmium is through food, and that cadmium within rice grains can be a major contributor to that dietary source. In this study genome wide association mapping was conducted on the Bengal and Assam Aus Panel (BAAP) of rice to identify quantitative trait loci and candidate genes for lowering grain cadmium. Field experiments were conducted over two years under two different irrigation systems: continually flooded and alternate wetting and drying (AWD). There was significant effects of water treatment, genotype, and genotype by water treatment interaction. Importantly, AWD increased grain cadmium, on average, by 49.6% and 108.8% in year 1 and 2 respectively. There was between 4.6 and 28 fold variation in cadmium concentration. A total of 58 QTLs were detected but no loci are clearly specific to one water regime despite approximately 20% of variation attributable to genotype by water regime interaction. A number of QTLs were consistent across most water treatments and years. These included QTLs on chromosome 7 (7.23–7.61, 8.93–9.04, and 29.12–29.14 Mbp), chromosome 5 (8.66–8.72 Mbp), and chromosome 9 (11.46–11.64 Mbp). Further analysis of the loci on chromosome 7 (8.93–9.04 Mbp), identified the candidate geneOsNRAMP1, where cultivars with a deletion upstream of the gene had higher concentrations of cadmium compared to the cultivars that did not have the deletion. The distribution of alleles within the BAAP suggest this QTL is easily detected in this population because it is composed ofauscultivars. Local genome cluster analysis suggest high Cd alleles are uncommon, but should be avoided in breeding.
ORCID-linked labeled data for evaluating author name disambiguation at scale
Authors: Kim Jinseok , Owen-Smith Jason 
Published: February 2021

AbstractHow can we evaluate the performance of a disambiguation method implemented on big bibliographic data? This study suggests that the open researcher profile system, ORCID, can be used as an authority source to label name instances at scale. This study demonstrates the potential by evaluating the disambiguation performances of Author-ity2009 (which algorithmically disambiguates author names in MEDLINE) using 3 million name instances that are automatically labeled through linkage to 5 million ORCID researcher profiles. Results show that although ORCID-linked labeled data do not effectively represent the population of name instances in Author-ity2009, they do effectively capture the ‘high precision over high recall’ performances of Author-ity2009. In addition, ORCID-linked labeled data can provide nuanced details about the Author-ity2009’s performance when name instances are evaluated within and across ethnicity categories. As ORCID continues to be expanded to include more researchers, labeled data via ORCID-linkage can be improved in representing the population of a whole disambiguated data and updated on a regular basis. This can benefit author name disambiguation researchers and practitioners who need large-scale labeled data but lack resources for manual labeling or access to other authority sources for linkage-based labeling. The ORCID-linked labeled data for Author-ity2009 are publicly available for validation and reuse.