bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of applied voltage waveform on the uniformity of a microplasma array confined inside polydimethylsiloxane microchannels
Authors: Wu Shuqun , Liu Xuhui , Ouyang Fan , Luo Yunxiang , Guo Yue , Zhang Chaohai 
Published: November 2021

AbstractThe uniformity of the microplasma array is essential to modify the hydrophilicity of the inner surface of polydimethylsiloxane (PDMS) microchannels by plasma treatment. In this study, the effects of applied voltage waveforms on the uniformity of the microplasma array are investigated. Interestingly, the microplasma array excited by AC (alternate current) voltage looks more “uniform” by a digital camera and has higher gas temperature and electron density than that excited by unipolar and bipolar pulse voltage. Imaging the microplasma array by a fast intensified charge‐coupled device camera shows that the ignition of microplasma inside each microchannel has strong randomness in spatial distribution, and the opportunity of each microchannel being ignited is almost equal. Detailed analysis reveals that the low density of surface charges and the small overvoltage in the case of AC voltage are expected to play crucial roles in the stochastic behavior of microplasma ignition inside PDMS microchannels. This study is useful for understanding the uniformity of the microplasma array for surface modification of PDMS microchannels.
Synthesis, Biological Evaluation and Docking Studies of Quinoline Pyrazolyl‐Chalcone Hybrids as Anticancer and Antimicrobial Agents
Authors: Kamra Nisha , Rani Suman , Kumar Devinder , Singh Ajeet , Sangwan Payare L. , Singh Shashank K. , Thakral Samridhi , Singh Vikramjeet 
Published: November 2021

AbstractA series of new quinoline pyrazolyl‐chalcone hybrids (4 a–4 s) was obtained from 4‐acetyl‐5‐methylquinolylpyrazole and aromatic aldehydes and the structure of these hybrids were established with the help of FTIR, 1D NMR (1H and13C), 2D NMR and HRMS data. The anticancer potential of selected quinoline pyrazolyl‐chalcone hybrids was evaluated against colon cancer (HT‐29, HCT‐116), lung cancer (A549), and prostate cancer (PC‐3) cell lines. (E)‐1‐(5‐Methyl‐1‐(4‐methylquinolin‐2‐yl)‐1H‐pyrazol‐4‐yl)‐3‐(2,4,6‐trimethoxyphenyl)prop‐2‐en‐1‐one (4 j) displayed good cytotoxicity with IC50values of 5.4, 3.2 and 2.8 μM against HT‐29, A549, and PC‐3 cancer cell lines, respectively. The antimicrobial potential of quinoline pyrazolyl‐chalcone hybrids was tested against three bacterial strains (B. subtilis,S. aureusandE. coli) and two fungal strains (A. nigerandC. albicans). (E)‐1‐(5‐Methyl‐1‐(4‐methylquinolin‐2‐yl)‐1H‐pyrazol‐4‐yl)‐3‐(3‐nitrophenyl)prop‐2‐en‐1‐one (4 r) exhibited significant activity against Gram positive bacteria (B. subtilisandS. aureus)and fungal strains with MIC value of 15.6 μM. Molecular docking analysis was conducted to determine the binding interactions of quinoline pyrazolyl‐chalcone hybrids with their respective biochemical targetsviz. Epidermal growth factor receptor tyrosine kinase (EGFR), Thymidylate kinase (TMK) andC. albicansN‐myristoyltransferase.
A meshless collocation method on nonlinear analysis of functionally graded hyperelastic plates using radial basis function
Authors: Hosseini Shahram , Rahimi Gholamhossein , Shahgholian‐Ghahfarokhi Davoud 
Published: November 2021

AbstractIn the present work, the nonlinear static analysis of functionally graded hyperelastic thin plate is investigated. The neo‐Hookean strain energy function and right Cauchy‐Green tensor are utilized to formulate the potential energy function. Also, the first‐order shear deformation theory of the plate is used to form the strain‐displacement relations. The strong form of the governing equations is derived using Euler‐Lagrange relations, and these relations are discretized using the meshless collocation method (MCM). The thin‐plate spline (TPS) radial basis function (RBF) is utilized to discretize the nonlinear governing equations, and the arc‐length continuation algorithm is used to solve the nonlinear algebraic system of equations. Square and circular plates with clamped and simply supported boundary conditions and various power‐law indexes are investigated using the MCM. The results are compared to those of the finite element method (FEM). The results show that the MCM is an accurate and efficient method in comparison to FEM for circular and square functionally graded (FG) hyperelastic thin plates.
The Trend of Deep Regional Integration
Authors: Jinji Naoto , Zhang Xingyuan , Haruna Shoji 
Published: November 2021

AbstractThe last quarter century until around 2016 has witnessed “unprecedented trade integration” (Baier et al. 2019) in the world. There has been a rapid proliferation of regional trade agreements (RTAs). Figure 2.1 shows the evolution of RTAs in the world since the World War II.
Conformal quantum mechanics & the integrable spinning Fishnet
Authors: Derkachov Sergey , Olivucci Enrico 
Published: November 2021

Abstract
In this paper we consider systems of quantum particles in the 4d Euclidean space which enjoy conformal symmetry. The algebraic relations for conformal-invariant combinations of positions and momenta are used to construct a solution of the Yang-Baxter equation in the unitary irreducibile representations of the principal series ∆ = 2 + iν for any left/right spins ℓ,$$ \dot{\ell} $$

ℓ
̇

of the particles. Such relations are interpreted in the language of Feynman diagrams as integral star-triangle identites between propagators of a conformal field theory. We prove the quantum integrability of a spin chain whose k-th site hosts a particle in the representation (∆k, ℓk,$$ \dot{\ell} $$

ℓ
̇

k) of the conformal group, realizing a spinning and inhomogeneous version of the quantum magnet used to describe the spectrum of the bi-scalar Fishnet theories [1]. For the special choice of particles in the scalar (1, 0, 0) and fermionic (3/2, 1, 0) representation the transfer matrices of the model are Bethe-Salpeter kernels for the double-scaling limit of specific two-point correlators in the γ-deformed $$ \mathcal{N} $$
N
= 4 and $$ \mathcal{N} $$
N
= 2 supersymmetric theories.
p-form surface charges on AdS: renormalization and conservation
Authors: Esmaeili Erfan , Hosseinzadeh Vahid 
Published: November 2021

Abstract
Surface charges of a p-form theory on the boundary of an AdSd+1 spacetime are computed. Counter-terms on the boundary produce divergent corner-terms which holographically renormalize the symplectic form. Different choices of boundary conditions lead to various expressions for the charges and the associated fluxes. With the usual standard AdS boundary conditions, there are conserved zero-mode charges. Moreover, we explore two leaky boundary conditions which admit an infinite number of charges forming an Abelian algebra and non-vanishing flux. Finally, we discuss magnetic p-form charges and electric/magnetic duality.
Multi-omics prediction of oat agronomic and seed nutritional traits across environments and in distantly related populations
Authors: Hu Haixiao , Campbell Malachy T. , Yeats Trevor H. , Zheng Xuying , Runcie Daniel E. , Covarrubias-Pazaran Giovanny , Broeckling Corey , Yao Linxing , Caffe-Treml Melanie , Gutiérrez Lucı́a , Smith Kevin P. , Tanaka James , Hoekenga Owen A. , Sorrells Mark E. , Gore Michael A. , Jannink Jean-Luc 
Published: November 2021

Abstract
Key message
Integration of multi-omics data improved prediction accuracies of oat agronomic and seed nutritional traits in multi-environment trials and distantly related populations in addition to the single-environment prediction.

Abstract
Multi-omics prediction has been shown to be superior to genomic prediction with genome-wide DNA-based genetic markers (G) for predicting phenotypes. However, most of the existing studies were based on historical datasets from one environment; therefore, they were unable to evaluate the efficiency of multi-omics prediction in multi-environment trials and distantly related populations. To fill those gaps, we designed a systematic experiment to collect omics data and evaluate 17 traits in two oat breeding populations planted in single and multiple environments. In the single-environment trial, transcriptomic BLUP (T), metabolomic BLUP (M), G + T, G + M, and G + T + M models showed greater prediction accuracy than GBLUP for 5, 10, 11, 17, and 17 traits, respectively, and metabolites generally performed better than transcripts when combined with SNPs. In the multi-environment trial, multi-trait models with omics data outperformed both counterpart multi-trait GBLUP models and single-environment omics models, and the highest prediction accuracy was achieved when modeling genetic covariance as an unstructured covariance model. We also demonstrated that omics data can be used to prioritize loci from one population with omics data to improve genomic prediction in a distantly related population using a two-kernel linear model that accommodated both likely casual loci with large-effect and loci that explain little or no phenotypic variance. We propose that the two-kernel linear model is superior to most genomic prediction models that assume each variant is equally likely to affect the trait and can be used to improve prediction accuracy for any trait with prior knowledge of genetic architecture.
Using structural break inference for forecasting time series
Authors: Altansukh Gantungalag , Osborn Denise R. 
Published: November 2021

AbstractRather than relying on a potentially poor point estimate of a coefficient break date when forecasting, this paper proposes averaging forecasts over sub-samples indicated by a confidence interval or set for the break date. Further, we examine whether explicit consideration of a possible variance break and the use of a two-step methodology improves forecast accuracy compared with using heteroskedasticity robust inference. Our Monte Carlo results and empirical application to US productivity growth show that averaging using the likelihood ratio-based confidence set typically performs well in comparison with other methods, while two-step inference is particularly useful when a variance break occurs concurrently with or after any coefficient break.
Initial Angiotensin Receptor Blocker Response in Young Marfan Patients Decreases After 3 Years of Treatment
Authors: Pees Christiane , Heno Julian , Michel-Behnke Ina 
Published: November 2021

AbstractMarfan syndrome is caused by mutations of the fibrillin-1 gene, which weakens the connective tissue integrity. Since 2003, bioavailability regulations of TGF-ß through fibrillin alterations have been presumed of being the culprit mechanisms for aortic aneurysm development. We present the analysis of our single-center Marfan children and adolescents cohort to assess the influence of age, sex, degree of cardiovascular involvement and dosage on losartan effectivity. This prospective longitudinal registered echocardiographical investigation (EudraCT 2009-016139-36) of 49 patients with an average follow-up of 72 months focused on aortic root z-scores, elasticity, and yearly progression rates. The 33 patients under medication with losartan showed an aortic root z-score reduction during the first 36 months compared to 22 patients without medication presenting constant mild progression. Yet, results diminished under losartan thereafter, adding up to similar progressions over 72 months in both groups (0.07 ± 0.10/year versus 0.04 ± 0.11/year). Although male patients exhibited higher root z-scores, progression with and without medication was comparable to females and not age-dependent. In conclusion, losartan evoked a significant aortic root z-score regression in young Marfan patients over the first 3 years, but this effect mitigated thereafter. The initial improvement concurred with ameliorated elasticity; lower stiffness levels predicted better clinical outcome, but likewise only up to 36 months. Sex differences in dilatation severity were observed but neither age nor sex had significant influence on progression rates. Losartan dosages were gradually increased in more severely affected patients and provided an equal rate of root progression over 72 months in comparison to patients under losartan treatment with lesser baseline dilatation severity.
On the Diurnal Cycle of Heavy Rainfall over the Sichuan Basin during 10–18 August 2020
Authors: Xia Rudi , Luo Yali , Zhang Da-Lin , Li Mingxin , Bao Xinghua , Sun Jisong 
Published: November 2021

AbstractA sustained heavy rainfall event occurred over the Sichuan basin in southwest China during 10–18 August 2020, showing pronounced diurnal rainfall variations with nighttime peak and afternoon minimum values, except on the first day. Results show that the westward extension of the anomalously strong western Pacific subtropical high was conducive to the maintenance of a southerly low-level jet (LLJ) in and to the southeast of the basin, which favored continuous water vapor transport and abnormally high precipitable water in the basin. The diurnal cycle of rainfall over the basin was closely related to the periodic oscillation of the LLJ in both wind speed and direction that was caused by the combination of inertial oscillation and terrain thermal forcing. The nocturnally enhanced rainfall was produced by moist convection mostly initiated during the evening hours over the southwest part of the basin where high convective available potential energy with moister near-surface moist air was present. The convective initiation took place as cold air from either previous precipitating clouds from the western Sichuan Plateau or a larger-scale northerly flow met a warm and humid current from the south. It was the slantwise lifting of the warm, moist airflow above the cold air, often facilitated by southwest vortices and quasi-geostrophic ascent, that released the convective instability and produced heavy rainfall.
Long-lasting olfactory dysfunction in COVID-19 patients
Authors: Prem Bernhard , Liu David T. , Besser Gerold , Sharma Gunjan , Dultinger Laura E. , Hofer Sissy V. , Matiasczyk Martina M. , Renner Bertold , Mueller Christian A. 
Published: November 2021

Abstract
Objectives
Olfactory dysfunction (OD) is a common symptom of Coronavirus Disease 2019 (COVID-19). Although many patients have been reported to regain olfactory function within the first month, long-term observation reports vary. Therefore, we aimed to assess the course of chemosensory function in patients diagnosed with COVID-19 within 3–15 months after the infection.

Methods
One hundred and two patients (71 females and 31 males; mean age 38.8 years) diagnosed with laboratory-confirmed COVID-19 and subjective OD participated in this single-center study 111–457 days after onset of OD. Patients first performed chemosensory tests at home, followed by psychophysical testing (Sniffin’ Sticks (TDI), 27-item Candy Smell Test (CST), Taste Strips Test (TST)) in the clinic. Questionnaires regarding importance of olfaction (IOQ) and olfactory-specific quality of life (QOD) were applied at both timepoints.

Results
After a mean 216 days (SD 73; range 111–457) between OD onset and follow-up testing, the mean Sniffin’ Sticks (TDI) score was 27.1 points (SD 5.8; range 4.25–38.5): 4.0% were anosmic, 72.5% hyposmic, and 23.5% normosmic. At follow-up testing, 73.5% of patients reported improvement, 5.9% deterioration, and 20.6% no change in OD. Moreover, full recovery of self-perceived smell, flavor, and taste was not observed. According to questionnaires, the individual importance of smell did not change, but participants showed improvement in OD-related quality of life (p < 0.001) and had increased parosmia scores (p = 0.014) at follow-up.

Conclusion
Our results show that long-lasting OD after SARS-CoV-2 infection is a common symptom. The majority of patients had OD in the range of hyposmia, which was confirmed by comprehensive smell tests.
Mammalian animal models for dengue virus infection: a recent overview
Authors: Kayesh Mohammad Enamul Hoque , Tsukiyama-Kohara Kyoko 
Published: November 2021

AbstractDengue, a rapidly spreading mosquito-borne human viral disease caused by dengue virus (DENV), is a public health concern in tropical and subtropical areas due to its expanding geographical range. DENV can cause a wide spectrum of illnesses in humans, ranging from asymptomatic infection or mild dengue fever (DF) to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Dengue is caused by four DENV serotypes; however, dengue pathogenesis is complex and poorly understood. Establishing a useful animal model that can exhibit dengue-fever-like signs similar to those in humans is essential to improve our understanding of the host response and pathogenesis of DENV. Although several animal models, including mouse models, non-human primate models, and a recently reported tree shrew model, have been investigated for DENV infection, animal models with clinical signs that are similar to those of DF in humans have not yet been established. Although animal models are essential for understanding the pathogenesis of DENV infection and for drug and vaccine development, each animal model has its own strengths and limitations. Therefore, in this review, we provide a recent overview of animal models for DENV infection and pathogenesis, focusing on studies of the antibody-dependent enhancement (ADE) effect in animal models.
Sexual Consent Perceptions of a Fictional Vignette: A Latent Growth Curve Model
Authors: Willis Malachi , Jozkowski Kristen N. 
Published: November 2021

AbstractSexual consent can be conceptualized as a process of accumulating cues that build toward and continue throughout a consensual sexual encounter. How people perceive the cues of others during this process is an important aspect of consent. However, previous research has not investigated the trajectories of people’s consent perceptions throughout such a process. Using a novel staggered vignette protocol, we examined participants’ (N = 1218; 64.4% female) perceptions of fictional targets’ sexual consent at 11 time points. We tested latent growth curve models using multilevel structural equation modeling to examine trajectories in consent perceptions over the course of the vignette. We hypothesized that mean differences and rates of change would be associated with several constructs relevant to sexual consent. We found that initial consent perceptions and trends over the course of the vignette varied by whether the participant was a university student, by an alcohol manipulation in the vignette, by the fictional target’s sex, and by type of sexual behavior. Researchers should examine whether our findings on consent perceptions of a fictional vignette extend to people’s actual sexual encounters, including potential associations between the three primary aspects of sexual consent: perceptions, feelings, and communication.
The Duty of Violence
Authors: Chouraqui Frank 
Published: November 2021

AbstractThis essay argues that the deontological view of morality is connected to extreme and massive forms of violence through a kind of phenomenological necessity. In the first main section, I examine one family of such violence, which usually comes under the label of “religious violence”. I argue that it is not the religious element but the disqualification of context from the realm of justification which characterizes such violence. In the second main section, I examine the phenomenology of duty to conclude that duty, by definition, denies any normative relevance to context. In the third main section, I use this sketch of a phenomenology of duty to propose a hypothesis about the underpinnings of the connection between mass violence and duty, namely, that the notion of duty carries with it the exclusion of moderation, and places the agent before an impossible situation that can only be resolved by violence.
Modelling Robust Delivery Scenarios for a Fleet of Unmanned Aerial Vehicles in Disaster Relief Missions
Authors: Radzki G. , Golinska-Dawson P. , Bocewicz G. , Banaszak Z. 
Published: November 2021

AbstractBesides commercial and military applications, unmanned aerial vehicles (UAVs) are now used more commonly in disaster relief operations. This study proposes a novel model for proactive and reactive planning (different scenarios) that allow for a higher degree of realism, thus a higher likelihood for a mission of being executed according to the plan even when weather forecasts are changing. The novelty of this study results from the addition of a function of resistance of UAVs mission to changes in weather conditions. We link the influence of weather conditions on the UAV’s energy consumption. The goal is to ensure the completion of planned deliveries by a fleet of UAVs under changing weather conditions before their batteries discharge and to identify the emergency route for returned if the mission cannot be completed. An approach based on constraint programming is proposed, as it has proven to be effective in various contexts, especially related to the nonlinearity of the system’s characteristics. The proposed approach has been tested on several instances, which have allowed for analyzing how the plan of mission is robust to the changing weather conditions with different parameters, such as the fleet size, battery capacity, and distribution network layout.
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats
Authors: Dumbrava Danut-Adrian , Surugiu Roxana , Börger Verena , Ruscu Mihai , Tertel Tobias , Giebel Bernd , Hermann Dirk M. , Popa-Wagner Aurel 
Published: November 2021

AbstractSmall extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) promote neurological recovery after middle cerebral artery occlusion (MCAO) in young rodents. Ischemic stroke mainly affects aged humans. MSC-sEV effects on stroke recovery in aged rodents had not been assessed. In a head-to-head comparison, we exposed young (4–5 months) and aged (19–20 months) male Sprague–Dawley rats to permanent distal MCAO. At 24 h, 3 and 7 days post-stroke, vehicle or MSC-sEVs (2 × 106 or 2 × 107 MSC equivalents/kg) were intravenously administered. Neurological deficits, ischemic injury, brain inflammatory responses, post-ischemic angiogenesis, and endogenous neurogenesis were evaluated over 28 days. Post-MCAO, aged vehicle-treated rats exhibited more severe motor-coordination deficits evaluated by rotating pole and cylinder tests and larger brain infarcts than young vehicle-treated rats. Although infarct volume was not influenced by MSC-sEVs, sEVs at both doses effectively reduced motor-coordination deficits in young and aged rats. Brain macrophage infiltrates in periinfarct tissue, which were evaluated as marker of a recovery-aversive inflammatory environment, were significantly stronger in aged than young vehicle-treated rats. sEVs reduced brain macrophage infiltrates in aged, but not young rats. The tolerogenic shift in immune balance paved the way for structural brain tissue remodeling. Hence, sEVs at both doses increased periinfarct angiogenesis evaluated by CD31/BrdU immunohistochemistry in young and aged rats, and low-dose sEVs increased neurogenesis in the subventricular zone examined by DCX/BrdU immunohistochemistry. Our study provides robust evidence that MSC-sEVs promote functional neurological recovery and brain tissue remodeling in aged rats post-stroke. This study encourages further proof-of-concept studies in clinic-relevant stroke settings.