bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practicing Money Management Makes Things Better: Healthy Financial Behaviors Attenuates Associations among Insecure Attachment, Economic Abuse Victimization, and Hopelessness
Authors: Li Xiaomin , Khan Muhammad Aamir , Kuelz Ashley , Zhao Zuyi 
Published: January 2025

AbstractEconomic abuse, a form of intimate partner violence (IPV), is prevalent and harmful but often difficult to detect. Chinese young adults (ages 18–35) in cohabiting relationships represent a substantial yet under-researched group at a relatively high risk of economic abuse. To enhance understanding of the potential predictors and outcomes of economic abuse in this population, we examined young adults' developmental tasks of exploring finances and romance while planning their ideal future lives. Guided by attachment theory, economic empowerment, and the Vulnerability-Stress-Adaptation (VSA) model, we investigated (1) how romantic attachment orientations and financial behaviors interact in their association with economic abuse and (2) how economic abuse is associated with hopelessness among a sample of Chinese young adults in cohabiting relationships. We used cross-sectional survey data from 445 young adults in Mainland China and employed structural equation modeling to assess our research questions. We found that young adults with avoidant or anxious attachment styles were more likely to experience economic abuse, which was, in turn, associated with higher levels of hopelessness. Additionally, healthy financial behaviors mitigated the association between attachment anxiety and avoidance, economic abuse, and hopelessness. Collectively, our findings advance the understanding of the potential predictors and consequences of economic abuse. They also underscore the importance of financial education in reducing economic abuse and its negative outcomes among Chinese young adults in cohabiting relationships.
Characteristics and survival outcomes in pediatric patients with spinal chordomas: insights from the National Cancer Database and review of the literature
Authors: El-Hajj Victor Gabriel , Ranganathan Sruthi , Rajjoub Rami , Ghaith Abdul Karim , Theodore Nicholas , Elmi-Terander Adrian , Lubelski Daniel 
Published: January 2025

Abstract
Purpose
Spinal chordomas are aggressive tumors that rarely occur in the pediatric population. Demographics and post-treatment outcomes in this select group of patients is poorly studied. We hence aimed to analyze the clinical characteristics, demographics, and survival outcomes of pediatric patients with spinal chordomas, in contrast to the adult population. To address this, the literature was reviewed to evaluate the coverage on spinal chordomas of the pediatric population, and the National Cancer Database (NCDB) was analyzed to provide insights into the US experience over the past two decades.

Methods
A search of the literature was performed leveraging the MEDLINE and Web of Science electronic databases from inception until March 2024, using the keywords “spinal,” “chordoma,” and “pediatric”. Additionally, the NCDB was queried for pediatric patients (≤ 21 years) with chordoma treated between 2004 and 2017. Baseline characteristics, tumor specifics, treatment details, and survival outcomes were collected and analyzed.

Results
From the literature, 45 pediatric chordoma patients were identified, with a median age of 7 years. Most chordomas were in the cervical spine (40%), and 93% of the patients received surgical treatment. Gross total resection was achieved in 59% of cases, and 49% received adjuvant radiotherapy. Recurrence, metastasis, and mortality rates were 7%, 18%, and 24%, respectively at a median follow-up of 12 months. In the NCDB cohort, 53 pediatric patients (≤ 21 years) and 980 adults (> 21 years) were compared. Despite having smaller tumors in size, pediatric patients presented with more advanced tumors with a higher proportion of stage 4 tumors. They had more mobile spine chordomas (83% vs. 51%) and traveled further for treatment (57 vs. 27 miles). Pediatric patients also received higher radiation doses (5420 vs. 5049 cGy). Surgical resection and adjuvant radiotherapy were common treatments in both groups. After matching, outcomes, including survival rates and early mortality, were similar between age groups. Kaplan-Meier analysis showed no difference in overall survival probabilities between the age groups both prior to and after matching.

Conclusion
While pediatric patients with spinal chordomas present with more advanced stage tumors, they demonstrate similar overall survival outcomes when compared to adults. The current literature is mainly composed of single cases and other reports of low evidence levels.
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Authors: Helal Mohamed Mohsen , Ibrahim Arwa Amer , Beddor Ahmad , Kashbour Muataz 
Published: January 2025

Abstract
Huntington’s disease (HD) is a progressive neurodegenerative disease resulting from a mutation in the huntingtin (HTT) gene and characterized by progressive motor dysfunction, cognitive decline, and psychiatric disturbances. Currently, no disease-modifying treatments are available. Recent research has developed therapeutic agents that may have the potential to directly target the disease pathology, such as gene silencing or clearing the mutant protein. However, these agents are limited by their inability to cross the blood-brain barrier (BBB), preventing optimal therapeutic effects. Although various techniques have been explored to overcome the BBB, focused ultrasound (FUS) has emerged as a promising non-invasive therapeutic modality offering the potential for targeted intervention in neurodegenerative diseases, including HD. Preclinical studies demonstrated the safety and efficacy of FUS in delivering therapeutic agents, such as siRNAs and AAV vector-based gene therapy, resulting in significant reductions in mutant HTT expression and improvements in motor function in HD mouse models. Furthermore, the safety profile of FUS-induced BBB opening has been established in clinical trials on human patients of neurodegenerative diseases other than HD, showing no adverse effects on brain structure or function. This review provides a comprehensive overview of the current state of FUS research in HD and connects existing evidence from neurodegenerative disease studies with its promise in establishing disease-modifying therapies for HD.

Graphical Abstract
Scaffolded Affective Harm: What Is It and (How) Can We Do Something About It?
Authors: Mossner Carmen , Walter Sven 
Published: January 2025

AbstractSituated affectivity investigates how natural, material, and social environmental structures, so-called ‘scaffolds,’ influence our affective life. Initially, the debate focused on user-resource-interactions, i.e., on cases where individuals (‘users’) actively structure the environment (‘resource’) in beneficial ways, setting up scaffolds that allow them to solve routine problems, modify their means of coping with challenges, or avail themselves of new affective competences. More recently, cases of mind invasion have captured philosophers’ attention where the ways others structure the environment affect, or invade, people’s minds, typically without their awareness and with harmful consequences. This paper contributes to recent discussions about the variety of phenomena that can count as ‘scaffolded affectivity’ in general and ‘scaffolded affective harm’ in particular. It also addresses the emerging question of how harmful affective scaffolds can come to have a grip on people’s minds, despite their detrimental consequences. We first disentangle some misconceptions and illustrate how diverse (harmful) affective scaffolds can be. In contrast to recent approaches that have characterized scaffolds in largely descriptive terms, we then identify factors that can help explain why a given scaffold is effective in modifying people’s minds. We also try to shed light on why some agents and some social structures are especially likely to experience or cause scaffolded affective harm, respectively, by arguing that user-resource-interactions and mind invasions are not independent, but intimately intertwined and mutually reinforcing, especially in the digital domain. We conclude with a speculative suggestion for further research.
Matrix-Wigner global wave front sets in ultradifferentiable classes
Authors: Asensio Vicente 
Published: January 2025

AbstractWe study global wave front sets given by matrices of Wigner type and defined in spaces of globally $$\omega $$
ω
-tempered ultradistributions of Beurling type, extending and completing the results in Asensio (J Pseudo-Differ Oper Appl 14(2):27, 2023). In fact, this approach permits to unify previous analyses in the literature of this field and to include other quadratic time-frequency analysis representations that had not been considered there. Moreover, we prove that the range of matrices is optimal, in the sense that no further matrix-Wigner transform could describe the spaces of globally $$\omega $$
ω
-rapidly decreasing functions in terms of seminorms. Finally, wave front sets for concrete distributions are calculated.
Balancing landscape values and tourism choices: Integrating participatory mapping and the IPBES Values Typology
Authors: Solé Liliana , Hearn Kyle P. , Witra Tahjudil , Lechner Alex M. , Fagerholm Nora 
Published: January 2025

AbstractThe United Nations Educational, Scientific and Cultural Organization (UNESCO) Biosphere Reserves aim to balance nature and human coexistence, but increasing tourism challenges landscape management. The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) stresses the importance of understanding stakeholder values for effective management of natural spaces through a typology of intrinsic, instrumental, and relational values. This study applies this IPBES typology to tourism preferences in the Archipelago Sea Biosphere Reserve (ABR) using Public Participation Geographic Information Systems (PPGIS). A 2022 survey gathered data from 690 locals, recreationists, and tourists revealing intrinsic values as the most significant. Locals prioritized intrinsic and relational values, while recreationists and tourists emphasized relational and instrumental values. The study highlights a preference for small-scale tourism that preserves landscapes and heritage, illustrating the complexity of aligning stakeholder values in tourism and conservation. Insights from this research guide policymaking to better accommodate diverse values in protected areas.
Computer vision-based video signal fusion using deep learning architectures
Authors: Ghyabi Mehrdad , Lattanzi David 
Published: January 2025

AbstractStructural health monitoring (SHM) is one of the most important solutions to the ongoing problem of deteriorating infrastructure. A crucial type of data needed for SHM is the displacement response of structures under loading, as these can be directly related to integrity and system performance, or can be used indirectly in analysis of the infrastructure. Video-based displacement measurement has become an increasingly accessible and viable approach to SHM. There is now an array of computer vision methods that extract displacement measurements using different components of the underlying video signal. However, all of these approaches are known to suffer from high levels of noise relative to conventional sensor installations. This study considers how to employ deep learning-based data fusion that combines measurements from several video analysis approaches to enhance the signal to noise ratio (SNR), resulting in an ensemble measurement approach. The emphasis of the study is on a convolutional neural network (CNN) architecture. A generative adversarial network (GAN) approach was also evaluated but was not able to reliably converge during model training. The CNN approach was evaluated using an experimental dataset of vibrations from a lab-scaled structural system with varying dynamic properties. The results show that the CNN fusion approach improves the loss function significantly and serves to effectively denoise the individual signals extracted from the video.
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
Authors: Gu Xiaoxia , Zhang Xiaotian , Zhang Xueke , Wang Xinyu , Sun Weiguang , Zhang Yonghui , Hu Zhengxi 
Published: January 2025

AbstractIn the twenty-first century, we have witnessed multiple coronavirus pandemics. Despite declining SARS-CoV-2 cases, continued research remains vital. We report the discovery of sydowiol B, a natural product, as a dual inhibitor of SARS-CoV-2 main protease (Mpro) and papain-like protease (PLpro). Sydowiol B interacts with the nano-channel at the Mpro dimer interface and the PLpro active site. Molecular dynamics simulations suggest that sydowiol B inhibits Mpro by limiting active site expansion rather than inducing collapse. Furthermore, sydowiol B binding may amplify the fluctuation of two loops coordinating with the structural Zn2+ in PLpro, displacing Zn2+ from the zinc finger domain to the S2 helix. Sydowiol B and its analogue, violaceol I, exhibit broad-spectrum antiviral activity against homologous coronaviruses. Given the conservation of Mpro and PLpro, sydowiol B and violaceol I are promising leads for designing and developing anti-coronavirus therapies.
Graphical Abstract
The Role of Diet, Glycaemic Index and Glucose Control in Polycystic Ovary Syndrome (PCOS) Management and Mechanisms of Progression
Authors: Johnson Claire , Garipoğlu Gökçen , Jeanes Yvonne , Frontino Giada , Costabile Adele 
Published: January 2025

Abstract
Purpose of Review
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder with several causal pathways including impaired glucose tolerance, insulin resistance (IR), compensatory hyperinsulinemia and excess androgens (hyperandrogenism). This heterogeneous condition causes a range of reproductive, metabolic and psychological implications, the severity of which can differ between individuals depending on factors such as age, diet, ethnicity, genetics, medication, contraceptive use, adiposity, and Body Mass Index (BMI).

Recent Findings
Dietary interventions that focus on a low glycaemic index and glucose control are an efficient first-line dietary solution for the management of impaired glucose tolerance and IR, which subsequently improves weight management, quality of life and PCOS-related symptoms in individuals with this condition.

Summary
This review aims to explore the relevance of nutrition and more specifically, the association of glycaemic index and glycaemic load with PCOS, as well as to assess the potential benefits of manipulating those indexes in the dietary approach for this syndrome.
Understanding the influence of data characteristics on the performance of point-of-interest recommendation algorithms
Authors: Dietz Linus W. , Sánchez Pablo , Bellogín Alejandro 
Published: January 2025

AbstractPoint-of-interest (POI) recommendations are essential for travelers and the e-tourism business. They assist in decision-making regarding what venues to visit and where to dine and stay. While it is known that traditional recommendation algorithms’ performance depends on data characteristics like sparsity, popularity bias, and preference distributions, the impact of these data characteristics has not been systematically studied in the POI recommendation domain. To fill this gap, we extend a previously proposed explanatory framework by introducing new explanatory variables specifically relevant to POI recommendation. At its core, the framework relies on having subsamples with different data characteristics to compute a regression model, which reveals the dependencies between data characteristics and performance metrics of recommendation models. To obtain these subsamples, we subdivide a POI recommendation data set on New York City and measure the effect of these characteristics on different classical POI recommendation algorithms in terms of accuracy, novelty, and item exposure. Our findings confirm the crucial role of key data features like density, popularity bias, and the distribution of check-ins in POI recommendation. Additionally, we identify the significance of novel factors, such as user mobility and the duration of user activity. In summary, our work presents a generic method to quantify the influence of data characteristics on recommendation performance. The results not only show why certain POI recommendation algorithms excel in specific recommendation problems derived from a LBSN check-in data set in New York City, but also offer practical insights into which data characteristics need to be addressed to achieve better recommendation performance.
The role of the circadian timing system in sarcopenia in old age: a scoping review
Authors: Palmese Francesco , Druda Ylenia , Del Toro Rossella , Bedogni Giorgio , Domenicali Marco , Silvani Alessandro 
Published: January 2025

Abstract
Purpose
Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.

Methods
We developed a scoping review protocol following the PRISMA-ScR guidelines. Searches were conducted on PubMed, Scopus, Web of Science,

Results
We identified 373 papers from three online databases, screened 97 for full-text analysis. and selected 37 papers for inclusion. These papers included 17 primary research studies on human persons, focusing on cortisol and melatonin secretion, rest-activity rhythms, chrono-exercise, and chrono-dietary regimens, 9 primary research studies on animal models (mice, rats, fruit flies) focusing on direct expression measurement or mutations of core clock genes, and 11 narrative reviews.

Conclusion
While several reports supported the role of the circadian timing system in sarcopenia, specifically related to the aging process, the available evidence is fragmented and limited. The field is thus open to preclinical and clinical research that addresses the wide knowledge gaps in the available evidence, taking advantage of what has already been published to optimize and refine experimental and clinical protocols.
Microbial methanogenesis fueled by freshwater infiltration and oil biodegradation in the Siljan impact structure, Sweden
Authors: van Dam Femke , Kietäväinen Riikka , Westmeijer George , Reinhardt Manuel , Ono Shuhei , Dopson Mark , Ketzer Marcelo , McIntosh Jennifer C. , Drake Henrik 
Published: January 2025

AbstractDeeply fractured rocks of meteorite impact craters are suggested as prime niches for subsurface microbial colonization. Methane can be a product of such microbial communities and seeps of methane from impact craters on Earth are of strong interest as they act as analogs for Mars. Previous studies report signs of ancient microbial methanogenesis in the Devonian Siljan meteorite impact structure in Sweden, but the proportion of microbial methane, metabolic pathways, and potential modern activity remain elusive. In this study, gas composition, hydrochemistry, oil organic geochemistry, and microbial community analyses are reported in 400 m deep fractures of the Siljan impact structure. The results showed a dominantly microbial origin for methane, which was supported by highly negative δ13CCH4 and positive δ13CCO2 values along with multiply substituted isotopologues (Δ13CH3D) that indicated disequilibrium fractionation due to microbial kinetic isotope effects. The presence of C2 to C5 hydrocarbons suggested a minor thermogenic input in the gas mix. Characterization of the microbial community via 16S rRNA gene amplicon sequencing and real-time PCR indicated a low abundance of several methanogenic archaeal populations, which is common for settings with active methanogenesis. Evidence of oil biodegradation suggested that secondary microbial hydrocarbon utilization was involved in the methanogenesis. Low sulfate and high alkalinity in the groundwaters also suggested a dominantly microbial methane formation driven by infiltration of freshwater that was coupled to sulfate reduction and secondary utilization of early mature thermogenic hydrocarbons.
Plant–pathogen interactions and ambient pH dynamics
Authors: Li Zhi , Fan Yanchun , Wu Ronghui , Gao Min , Wang Xiping 
Published: January 2025

AbstractAmbient pH performs a crucial role in plant immunity, abiotic stress response, and plant growth and development. Plant–pathogen interactions influence a dynamic pH environment. Host acidification and alkalinization are under the regulating actions of acidophilic and alkaliphilic pathogens, respectively. Plasma membrane H+-ATPases regulate pH homeostasis, and their activity is modulated during pathogen-associated molecular pattern- (PTI) and effector-triggered immunities (ETI). Recent studies have provided insights into the interplay between pathogens and plants when controlling ambient pH. Here, we review pH dynamics in relation to plant immunity and focus on its relationships with PTI, ETI, stomatal immunity, programmed cell death, calcium ion (Ca2+), and reactive oxygen species. Comprehension of the complexity of ambient pH regulation may provide new strategies for plant disease control and sustainable agriculture.
Nature conservation and poverty alleviation through sustainable ecotourism: the case of Lolab Valley, India
Authors: Majeed Lone Rafiya , Rashid Sumaira , Sharma Deeplata , Majeed Lone Fawad , Bhat Mansoor Ahmad 
Published: January 2025

AbstractEcotourism is an important link between environmental conservation and poverty alleviation, as it generates income, empowers local communities, and provides educational benefits. This study focuses on the Lolab Valley in the remote Himalayan regions, emphasising its potential as one of India's premier sustainable tourism destinations. The primary goal of this study is to look into the future development of ecotourism in the area and to understand local perceptions and awareness of sustainable tourism between 2020 and 2023. To accomplish this, fieldwork was carried out that involved focus groups and semi-structured interviews, enabling a thorough investigation of the viewpoints of locals on sustainable tourism. To create a baseline understanding of the different types of tourism in the area, such as mountain, water, culinary, heritage, ethnographic, and creative tourism, the qualitative data that were gathered were examined. Based on our findings, travellers strongly favour sustainable travel over mass tourism. In particular, the option that participants preferred the most was mountain tourism (44%), followed by heritage tourism (20%), anthropological tourism (14%), water tourism (13%), and creative tourism (9%). This suggests that the community has undergone a substantial change in favour of sustainable tourism practices. This study demonstrates the significance of sustainable tourism over mass tourism and underscores the strong support of the local community for sustainable initiatives. Furthermore, it underscores the role of shared economies in mitigating poverty in the region. The Lolab Valley can make the most of its natural resources and maintain the welfare of its communities by promoting sustainable tourism.