bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems of qualification of the Georgian-Ossetian conflict in the context of the process of federalization of the Russian Republic of 1917-1922.
Authors: Бежанов А.В. 
Published: September 2021

Автор статьи выявляет неверную квалификацию так называемого грузино-осетинского конфликта, вызванную ошибочной исторической интерпретацией международной правосубъектности сторон конфликта. На основании метода исторко-правового анализа документов и норм национального и международного права в настоящей статье описывается факт вхождения единой Осетии в состав РСФСР в 1921 году. На основании этого факта в статье рассматривается правосубъектность двух суверенных государств (ГССР и РСФСР) в контексте правомочности их юрисдикции на территории Осетии, для политико-правового анализа ответственности каждого из них за нарушение целостности Осетии и этнического суверенитета осетин. В силу неделимого качества этнического суверенитета осетин, она путем самоопределения могла быть передана только одному федеративному государству – Российской Федерации. Автор статьи квалифицирует конфликт как грузино-российский, что открывает совершенно новый подход к урегулированию конфликта посредством переноса его на открытый равносторонний международный уровень.
Investigating the problems of the so-called Georgian-South Ossetian confl ict, the author of the article revealed an incorrect qualifi cation of the confl ict caused by an erroneous historical interpretation of the international legal personality of the parties to the confl ict.Based on the method of historical and legal analysis of documents and norms of national and international law, this article reveals the fact of the entry of united Ossetia into the RSFSR in 1921. Based on this fact, the article examines the legal personality of two sovereign states (the SSR of Georgia and the RSFSR) in the context of the legitimacy of their jurisdiction on the territory of Ossetia, for a political and legal analysis of the responsibility of each of them for violating the integrity of Ossetia and the ethnic sovereignty of the Ossetians. Due to the indivisible quality of the ethnic sovereignty of the Ossetians, it could be transferred by self – determination to only one federal state-the Russian Federation. Due to this fact, and the impeccable international legal personality of Georgia and Russia as actual members of the UN, the author of the article qualifi es the confl ict as Georgian-Russian, which opens up a completely new approach to resolving the confl ict by transferring it to an open equilateral international level.
Guarantees of men's rights in family law
Authors: Галазова З.В. 
Published: September 2021

В настоящей статье рассматриваются вопросы гендерного равенства в семейных правоотношениях и отдельные вопросы правового регулирования института отцовства в Российской Федерации. В статье проведен анализ конституционных норм, норм семейного законодательства, а также международных актов, демонстрирующих проблемы в механизмах, обеспечивающих равную реализацию прав мужчине и женщине в вопросах семьи.
This article examines the issues of gender equality in family legal relations and certain issues of legal regulation of the institution of fatherhood in the Russian Federation. The article analyzes constitutional norms, norms of family legislation, as well as international acts that demonstrate problems in mechanisms that ensure equal realization of rights for men and women in family matters.
Biochemical indicators of sports achievements in highly qualified wrestlers
Authors: Alpatov S. P. , Konovalov I. V. , Dibirova G. O. , Kalinina E. V. , Mileshina S. E. , Tsitsuashvili M. D. , Zhirova I. A. , Kochetov A. G. , Parastaev S. A. 
Published: September 2021

Objective: to conduct comparative analysis of blood biochemical parameters (urea, ALT, AST, creatinkinase, cortisol, testosterone and testosterone / cortisol ratio) in groups of high­class wrestlers with different levels of sports achievements.Materials and methods: male athletes (n = 78), members of the Russian national team in one of the types of wrestling (the average age is 25.2 (21.5–28.9) years, the average weight is 76.9 (68.4–83.4) kg) were recruited to this study. The examined athletes were divided into two groups according to their sporting achievements. The first one — SHA group (super­high achievements) which included athletes (n = 19) who had victories and prizes at the largest international competitions (European, World, Olympic Games), and the second group — MNT group (members of the national team) which included athletes that did not have similar achievements (n = 59). The following biochemical parameters were studied: urea, creatine kinase, ALT, AST, testosterone, cortisol, anabolic index (AI).Results: the absolute values of all metabolites in the examined athletes were within the reference intervals. Statistically significant differences in most of the biochemical parameters were revealed between the compared groups in terms of the level of sports achievements. The SHA group showed a statistically significant shift in relation to MNT group, in direction of increasing the level of metabolites that characterize the predominance of anabolic processes — ALT, testosterone, AI. Metabolite levels, increase which reflects catabolic processes activity and inadequate or insufficient adaptation processes, in the SHA group were significantly lower than in the MNT group. The above changes of the absolute values of biochemical parameters were confirmed by correlation analysis.Conclusions: the obtained results allow us to state the optimal adaptation of this sport, the adequacy of metabolic processes in the group of highly qualified athletes.
Psychophysiological processes, ensuring the achievement of sports results
Authors: Vaguine Yu. E. 
Published: September 2021

Objective: to investigate the role of psychophysiological processes in achieving sports results.Materials and methods: the driving force of sports behavior was measured in free­divers, basketball players and athletes, which consisted of motivation to achieve sports results, emotional stress, situational information, hypoxic stability, and physical endurance. Then the sportsmen rotated the pedals of the bicycle ergometer with simultaneous intermittent breath holdings from 20 to 60 s.Results: it has been established that all components of the driving force of behavior are necessary for the sports activity of all groups of sportsmen. For the driving force of free­divers’ behavior, hypoxic stability is of greatest importance (r = 0.59), for basketball players — emotional stress (r = 0.6) and for athletes — emotional stress and situational information (r = 0.71 and 0.58). In addition, hypoxic stability and physical endurance directly affect the final sports result (r = 0.7 and 0.65) in conjunction with the driving force of behavior (r = 0.53).Conclusion: sports result is provided by the driving force behind the behavior of sportsmen. For free­divers, hypoxic stability is of primary importance, for basketball players — physical endurance and emotional stress, and for athletes — the totality of all components of the driving force of behavior.
Study of the association of gene polymorphism with the risk of non-communicable diseases in martial artists
Authors: Sorokina E. Yu. , Pogozheva A. V. , Nikityuk D. B. 
Published: September 2021

Objective: to study the effect of genetic polymorphisms: rs rs9939609 (FTO gene), rs4994 (ADRB3 gene), rs1042713 (ADRB2 gene), rs2228570 (VDR gene), rs1801133 (MTHFR gene) on anthropometric and lipid metabolism indicators in athletes representing martial arts.Materials and methods: studies of anthropometric and biochemical parameters, genetic polymorphisms were carried out in 120 athletes (101 men and 19 women) who are engaged in martial arts. Anthropometric studies were performed by measuring height (cm), body weight (kg), followed by calculating body mass index (BMI, kg / m2). Biochemical nutritional status markers were determined using the ABX Pentra 400 analyzer (HORIBA ABX SAS, France) in an automatic mode. Genotyping was performed using allele­specific amplification using TaqMan probes complementary to polymorphic DNA regions and real­time detection of the results using reagent kits from Syntol, Russia. Studies were performed on the device CFX96 Real Time System (Bio­Rad, USA). Statistical processing of the results was performed using the PASW Statistics 20 system.Results: as a result of generic Diovan athletes martial artists on the risk of non­communicable diseases, discovered that the frequency of allele A of rs9939609 polymorphism of the FTO gene they have is 43.9 %, allele polymorphism rs4994 ADRB3 gene — 10.9 %, G allele of rs1042713 ADRB2 gene polymorphism — 52.6 %, G allele of the polymorphism rs2228570 VDR gene with 44.9 % and allele t of rs1801133 in the MTHFR gene to 36.7 %. An association was found between the value of anthropometric indicators in male martial artists and the presence of polymorphisms rs9939609 (FTO), rs1042713 (ADRB2) and rs2228570 (VDR).Conclusions: the reason for the identified dyslipidemia in martial artists may be not only the previously detected violations of the structure of their nutrition, but also the presence of certain genetic polymorphisms, in particular, rs4994 of the ADRB3 gene and rs1042713 of the ADRB2 gene.
Pilot study on the evaluation of the effectiveness of psychocorrection methods that include EEG-training and VR headset in athletes involved in extreme kinds of sports
Authors: Pustovoit V. I. , Nazaryan S. E. , Adoeva E. Ya. , Klyuchnikov M. S. , Kirichenco N. A. , Samoilov A. S. 
Published: September 2021

Objective: to evaluate the effectiveness of psychocorrection based on the methods of self­regulation in athletes.Materials and methods: the effectiveness was evaluated on 104 male athletes who had an optimal level of psychoemotional state of the body during a background examination by electroencephalography (EEG). The subjects were randomly assigned to three groups of psychocorrection: control, EEGtraining, and VR­therapy. Mathematical and statistical processing was carried out in Statistica 7.Results: the average values of the wave intensity index (WII) after psychological correction using the following methods: EEG­training and VRtherapy showed positive EEG dynamics in athletes of the second group (EEG­training) 65,6 % (21) and the third group (Vr­therapy) 73,8 % (31) of the subjects, respectively. Whereas in the control group, self­healing was recorded in 9 (30 %) athletes without psychocorrection procedures.Conclusion: the quantitative criterion of WII is a universal informative indicator of the functional activity of the brain for evaluating the effectiveness of psychocorrection aimed at optimizing the psychoemotional state. Psychocorrection of athletes using EEG­training and VR­therapy provides efficiency in 73.8 and 65.6 % of cases, which significantly softens pre­start tension as a result of reducing anxiety and restoring the psychoemotional state of the body to an optimal level by involving the psychological reserve.
The Impact of Sleep Deprivation on Work Performance towards Night-shift Healthcare Workers: An Evidence-based Case Report
Authors: Habiburrahman Muhammad , Lesmana Elvira , Harmen Fadhilah , Gratia Nadya , Mirtha Listya Tresnanti 
Published: September 2021

Background. Poor sleep and excessive fatigue among workers can reduce well-being and physical fitness. However, not many studies have mentioned how sleeping deprivation among night-shift healthcare workers impacted their work performance in multiple aspects.
Method. We conducted an evidence-based case report (EBCR) of a night shift nurse who was worried about the impact of her sleep deprivation on her work performance in the future due to prior history of needle-stick injuries. We aimed to determine whether sleeping deprivation caused by regular night shifts leads to decreased work performance among night-shift healthcare workers by formulating a clinical question. Evidence was searched systematically using five major journal databases (Proquest, EBSCO-Host, PubMed, ScienceDirect, and Cochrane) and was assessed thoroughly using inclusion and exclusion criteria.
Results. Eleven eligible studies were obtained with a medium level of evidence (III-IV), three systematic reviews with meta-analyses (SR-MA), three SR without MA, and five observational studies. All of them were analyzed and critically appraised using Oxford Evidence-Based Medicine and Joanna Briggs Institute tools. We found that reduced quantity and quality of sleep impacted all dimensions of work performance among healthcare professionals, be it in task performance (e.g., skill proficiency), contextual performance (e.g., communication skill and mental health issues), and patient and health worker safety (accident and medication error). It could also encourage counterproductive work behavior, such as absenteeism. Furthermore, sleep deprivation changes circadian rhythms, causing decreased information processing and affective recognition functions in some vital brain areas, ultimately affecting several work dimensions.
Conclusion. In conclusion, stakeholders need to adjust proper shift scheduling for health care workers, practice sleep hygiene, maintain physical fitness, and consume nutritional food, positively correlated to health and productivity.
Exploring the Role of Occupational Therapy With Mothers Who Breastfeed
Authors: Sponseller Lauren , Silverman Fern , Roberts Pamela 
Published: September 2021

Importance: Occupational therapy practitioners can play a pivotal role in supporting breastfeeding mothers as they transition to and form new routines for this occupation.
Objective: To explore whether occupational therapy programming can assist breastfeeding mothers in reaching their personal occupation-based wellness goals.
Design: Mixed-methods design that involved development of an occupational profile and a goal attainment scale (GAS). After the intervention, participants rescored their GAS goals and completed a semistructured exit interview.
Setting: Nonprofit lactation center located in the suburbs of a large mid-Atlantic U.S. city.
Participants: Women recruited through convenience sampling who had been breastfeeding an infant for &lt;6 mo, who were not currently weaning, and who had met with a lactation consultant at least once since giving birth were eligible (N = 17).
Intervention: Group occupational therapy that consisted of 10 weekly 1-hr sessions. Topics were based on occupational profiles, GAS scores, and lactation consultant input.
Outcomes and Measures: Each participant created and scored three goals using the GAS before and after the intervention.
Results: Data from 14 of the 17 participants were analyzed. The average postintervention GAS score was 56.50 (M = 50), indicating that most personal wellness goals were reached. Thematic analysis revealed that occupational therapy programming helped mothers persevere with breastfeeding, feel more confident as new parents, and value both themselves and their baby.
Conclusions and Relevance: There is an increasing role for occupational therapy practitioners in helping new mothers reach their personal wellness goals in ways that support their ability to continue breastfeeding.
What This Article Adds: Maternal wellness and breastfeeding represent an emerging area of practice in which occupational therapy practitioners can provide new mothers with physical, social, and psychological supports that help them maintain self-efficacy related to breastfeeding and other meaningful occupations. This study provides foundational evidence in support of this collaboration.
Effect of progressive resisted exercises and aerobic exercises in the management of polycystic ovarian syndrome among young women- A pilot randomized controlled trial
Authors: Kirthika S. Veena , Paul Jibi , Selvam P. Senthil , Priya V. Sathya 
Published: September 2021

Introduction and Aim: Polycystic ovarian syndrome (PCOS) is a heterogenous, multisystem endocrinopathy in women of reproductive age also called as Stein Leventhal syndrome. PCOS is a common female endocrine disorder with prevalence ranging from 2.2% to 26%. Prevalence of PCOS in Indian adolescents is 9.13%. This draws attention to the issue of early diagnosis in adolescent girls. The aim of this study was to determine the effect of progressive resisted exercises (PRE) and aerobic exercises in the management of subjects with PCOS.
Materials and Methods: This was an experimental comparative pre and post-test type study. The subjects in the age group of 18-25 years with the diagnosis of PCOS were selected based on Rotterdam criteria and with the BMI ranging between 25-29. Twenty four subjects were recruited and were randomly divided into two groups. group A was treated with PRE +aerobic exercises + diet and group B with aerobic exercises + diet. The duration of the study was 24 weeks and the outcome measures used were BMI, PCOSQ and hormonal levels (SHBG, Free testosterone, HOMA IR, Hs CRP)
Results: The result of the study showed that group A treated with PRE + aerobic exercises + diet had significant improvement in BMI at P?0.05 and PCOSQ and specific hormonal levels at P?0.001 when compared to group B.
Conclusion: A 24 weeks exercise intervention with a combined PRE +aerobic exercises +diet was superior to aerobic exercises +diet among young subjects with PCOS.
Keywords: BMI; quality of life; PRE; PCOSQ; Hormones.
Fedratinib (Inrebic)
Authors: Reimbursement Team  
Published: September 2021

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses fedratinib (Inrebic), 100 mg capsules.
Indication: For the treatment of splenomegaly and/or disease-related symptoms in adult patients with intermediate-2 or high-risk primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis, including patients who have been previously exposed to ruxolitinib.
Venetoclax (Venclexta)
Authors: Team Reimbursement 
Published: September 2021

CADTH recommends that Venclexta in combination with azacitidine should be reimbursed for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) who are 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy, only if certain conditions are met.
Venclexta plus azacitidine should only be reimbursed if prescribed by clinicians who have expertise in managing patients with AML and are familiar with the toxicity profile of this regimen, and if the costs of Venclexta and azacitidine are reduced.
Venclexta plus azacitidine should only be covered to treat adult patients who are considered ineligible for standard intensive induction chemotherapy and have not been treated with venetoclax or chemotherapy for myelodysplastic syndrome.
Upadacitinib (Rinvoq)
Authors: Team Reimbursement 
Published: September 2021

CADTH recommends that Rinvoq should be reimbursed by public drug plans for the treatment of active psoriatic arthritis (PsA) if certain conditions are met.
Rinvoq should only be reimbursed if it is prescribed by a rheumatologist or a clinician who has experience treating adult patients with active PsA and if it does not cost more than other biologic disease-modifying antirheumatic drugs (bDMARDs) or targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs).
Rinvoq should only be covered to treat adult patients with active PsA who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs) in a similar way to other bDMARDs currently reimbursed by public drug plans.
Utilization Patterns of Disease-Modifying Antirheumatic Drugs for the Treatment of Rheumatoid Arthritis: Rationale for Improving the Harmonization of Coverage Criteria
Authors: Tadrous Mina , Lončar Mirhad , Dyrda Peter 
Published: September 2021

Utilization patterns of csDMARDs were highly comparable between drug plans overall (in decreasing order: methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, and azathioprine). The proportion of csDMARDs were comparable (e.g., approximately 30% of csDMARD use for methotrexate), although differences in coverage criteria may have resulted in variances in the use of leflunomide. Differences in adjudication of coverage criteria may have resulted in a modest variance in the number of csDMARDs used prior to initiating bDMARDs (i.e., allowing for an “early escape” to bDMARDs for some jurisdictions such as Manitoba and the Atlantic provinces).
The mean time to initiate bDMARD therapy (range of 664 to 792 days) revealed a divergence between jurisdictions into 2 groupings whereby Manitoba, Saskatchewan, and the Atlantic provinces drug plans (mean time of 664 to 681 days) saw the initiation of bDMARDs approximately 4 months faster versus other jurisdictions (British Columbia, Alberta, and Ontario, with a mean time of 748 to 792 days), possibly due to their coverage criteria not requiring 3 lines of csDMARDs therapy. Despite differences in the time to initiate bDMARDs, there was no notable difference in the persistence of bDMARDs 6 months after the initiation for any drug plan (61% to 76% range for patients 67 years of age and older).
Utilization patterns of bDMARDs was highly comparable between drug plans (i.e., highest use with adalimumab, etanercept, and infliximab), although British Columbia and Manitoba were the only jurisdictions that saw decreasing costs per patient of bDMARDs over time, likely due to a higher uptake of biosimilars or other managed formulary strategies such as tiering.
Risdiplam (Evrysdi)
Authors: Reimbursement Team  
Published: September 2021

CADTH recommends that Evrysdi should be reimbursed by public drug plans for the treatment of spinal muscular atrophy (SMA) in patients aged 2 months and older, if certain conditions are met.
Evrysdi should only be reimbursed if the patient is under the care of a specialist with experience in the diagnosis and management of SMA, it is not used in combination with nusinersen or onasemnogene abeparvovec, and the price is reduced.
Evrysdi should only be reimbursed to treat patients aged 2 months to 7 months with genetic documentation of 2 or 3 copies of the survival motor neuron 2 (SMN2) gene or non-ambulatory patients aged 8 months to 25 years with genetic documentation of 2 or 3 copies of the SMN2 gene. Patients are ineligible if they currently require permanent invasive ventilation. After 12 months of treatment, patients should be assessed to ensure clinical benefit.
Hip Protectors for Community-Dwelling Older Adults
Authors: Farrell Keeley , Walter Melissa 
Published: September 2021

In community-dwelling older adults who wore hip protectors there was no difference in the risk of hip fractures or pelvic fractures, compared to those who did not wear hip protectors.
Three guidelines were identified that include recommendations around the use of hip protectors in older adults. One guideline suggests that hip protectors should be considered in adults at risk for falls and hip fracture. One guideline conditionally recommends hip protectors for frail older adults in the appropriate environment. One guideline suggests that hip protectors should not be considered in older adults in community settings.
Durvalumab (Imfinzi)
Authors: Reimbursement Team  
Published: September 2021

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses Durvalumab (Imfinzi) concentrate for solution for infusion, 50 mg/mL, IV.
Indication: First-line treatment of adult patients with extensive-stage small cell lung cancer, in combination with etoposide and either carboplatin or cisplatin