bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis
Authors: Nee Kevin , Ma Dennis , Nguyen Quy H. , Pervolarakis Nicholas , Insua-Rodríguez Jacob , Pein Maren , Gong Yanwen , Hernandez Grace , Alshetaiwi Hamad , Williams Justice , Rauf Maha , Dave Kushal Rajiv , Boyapati Keerti , Calderon Christian , Markaryan Anush , Edwards Robert , Lin Erin , Parajuli Ritesh , Zhou Peijie , Nie Qing , Shalabi Sundus , LaBarge Mark A. , Kessenbrock Kai 
Published: October 2021

SummaryWomen with germline mutations in BRCA1 (BRCA1+/mut) have increased risk for developing hereditary breast cancer1, 2. Cancer initiation in BRCA1+/mut is associated with pre-malignant changes in the breast epithelium including altered differentiation3–5, proliferative stress6 and genomic instability7. However, the role of the epithelium- associated stromal niche during BRCA1-driven tumor initiation remains unclear. Here, we show that the pre-malignant stromal niche promotes epithelial proliferation and BRCA1- driven cancer initiation in trans. Using single-cell RNAseq (scRNAseq) analysis of human pre-neoplastic BRCA1+/mut and control breast tissues, we show that stromal cells provide numerous pro-proliferative paracrine signals inducing epithelial proliferation. We identify a subpopulation of pre-cancer associated fibroblasts (pre-CAFs) that produces copious amounts of pro-tumorigenic factors including matrix metalloproteinase 3 (MMP3)8, 9, and promotes BRCA1-driven tumorigenesis in vivo. Our gene-signature analysis and mathematical modeling of epithelial differentiation reveals that stromal-induced proliferation leads to the accumulation of luminal progenitor cells with altered differentiation, and thus contributes to increased breast cancer risk in BRCA1+/mut. Our results demonstrate how alterations in cell-cell communication can induce imbalances in epithelial homeostasis ultimately leading to cancer initiation. We anticipate our results to form the foundation for novel disease monitoring and therapeutic strategies to improve patient management in hereditary breast cancer. For example, pre-CAF specific proteins may serve as biomarkers for pre-cancerous disease initiation to inform whether radical bilateral mastectomy is needed. In addition, MMP inhibitors could be re-indicated for primary cancer prevention treatment in women with high-risk BRCA1 mutations.
A bibliometric overview of the journal of historical research in marketing between 2009 and 2021
Authors: Akpınar Ayhan , Çetin Canberk , Tiltay Muhammet Ali 
Published: October 2021

Purpose
The purpose of this paper is to reveal the contributions of the Journal of Historical Research in Marketing (JHRM) to the academic body of knowledge. Pursuant to this objective, the study classifies the publications and citation structure of the JHRM, the nature of the publications’ authorship, the most cited articles and authors and the themes that have been covered from the first day until now (2009–2021).

Design/methodology/approach
This paper uses bibliometric methodologies to analyze several aspects of the JHRM.

Findings
The average number of citations per paper is 4.54. The number of articles studying marketing history/practice (163) and the history of thought (158) is almost equal, consistent with the journal’s primary orientation. Compared with other journals, it could be said that JHRM achieved close ranks, especially with those of other historical journals of similar age. The most prolific authors whose articles have been published in the JHRM are used in universities located in the USA. The JHRM is closely connected to top-tier journals in the field.

Research limitations/implications
This study is limited to one journal (JHRM) only. However, the authors assert that the articles analyzed are representative samples of the entire school of marketing history. Another important consideration is that the value of many critical studies in the social sciences cannot be determined using only bibliometric measurements.

Originality/value
This paper contributes to the marketing literature from several perspectives. First, evaluating the JHRM in terms of its unique standing shows the scope of the field of marketing history. Second, it serves as a guide for existing and future authors regarding the JHRM and the history of marketing. Third, the JHRM’s contributions provide insights into emerging trends and new opportunities for the entire marketing community.
An exploration of the motivating factors for the preparation of an integrated report in contextual settings
Authors: Sciulli Nick , Adhariani Desi 
Published: October 2021

Purpose
It is 10 years since the International Integrated Reporting Council (IIRC) was founded and the development of the IIRC Framework has been adopted by thousands of organisations. This paper aims to provide empirical evidence on the motivation for the preparation of integrated reports from a diffusion of innovation (DOI) perspective.

Design/methodology/approach
Three case study organisations operating in distinct industry sectors are investigated to ascertain the motivation for the adoption of integrated reporting. DOI theory was adopted as the theoretical lens to guide the research design. An interpretative approach is used to ascertain common themes from an analysis of semi-structured interview transcripts of senior managers and directors.

Findings
The findings from these case studies support the main tenets of DOIs theory. The evidence suggests that senior executive leadership plays a significant role in commencing the integrated reporting “journey”. This study finds evidence of DOI characteristics, such as relative advantage, compatibility and observability with respect to the objectives of senior managers. The main motivations for the production of the integrated report were to demonstrate leadership and innovation to stakeholders, overcome the perceived inadequacies of the disclosures required for traditional annual reports, to enhance transparency and to satisfy the changing demands of investors and other stakeholders.

Research limitations/implications
This project captures the perceptions and views of preparers of the integrated report rather than its users. In addition, only three case study sites were investigated, therefore, generalisations would be spurious.

Practical implications
Other organisations yet to consider the production of integrated reports or to re-assess their stakeholder relationships, could use these findings to plan for their own future reporting obligations.

Originality/value
The organisations investigated were a superannuation fund, a multinational company and a charity. All are recognised leaders in their respective industries.
Hydroxyapatite composite scaffold for bone regeneration via rapid prototyping technique: a review
Authors: Sun Fangfang , Wang Tianze , Yang Yong 
Published: October 2021

Purpose
Rapid prototyping (RP) technology is widely used in many fields in recent years. Bone tissue engineering (TE) is an interdisciplinary field involving life sciences, engineering and materials science. Hydroxyapatite (HAp) are similar to natural bone and it has been extensively studied due to its excellent biocompatibility and osteoconductivity. This paper aims to review nanoscaled HAp-based scaffolds with high porosity fabricated by various RP methods for bone regeneration.

Design/methodology/approach
The review focused on the fabrication methods of HAp composite scaffolds through RP techniques. The paper summarized the evaluation of these scaffolds on the basis of their biocompatibility and biodegradability through in vitro and in vivo tests. Finally, a summary and perspectives on this active area of research are provided.

Findings
HAp composite scaffold fabricated by RP methods has been widely used in bone TE and it has been deeply studied by researchers during the past two decades. However, its brittleness and difficulty in processing have largely limited its wide application in TE. Therefore, the formability of HAp combined with biocompatible organic materials and fabrication techniques could be effectively enhanced, and it can be used in bone TE applications finally.

Originality/value
This review paper presented a comprehensive study of the various types of HAp composite scaffold fabricated by RP technologies and introduced their potential application in bone TE, as well as future roadmap and perspective.
Deconstructingahimsaat the workplace: its relevance and significance
Authors: Sarkar Ayatakshee 
Published: October 2021

PurposeThis paper aims to conceptualize ahimsa at the workplace as an alternate coping response to negative workplace behaviours. The response strategy aims to impede conflict escalation and transform a hostile situation into a collaborative one.Design/methodology/approachThe conceptualization of the indigenous construct bases upon Bhawuk's methodological suggestion on building psychological models from the scriptures (Bhawuk, 2010, 2017, 2019). The construct ahimsa explicates by synthesizing the micro-world (Bhagawad Gita, BG and Patanjali Yoga Sutras, PYS) and through the lifeworld of Gandhiji.FindingsThe conceptual analysis illustrates the efficacy of ahimsa as an alternate response to negative workplace behaviours. The definition delineates its three core characteristics, i.e. conscious non-violent action, self-empowerment and rehumanizing the perpetrator. Besides, it proposes to enhance metacognition, creativity and individual learning at the workplace.Originality/valueThe conceptual paper gives a new direction to management researchers on coping and responding to stress.
Central and Northern European caterpillar assemblages show strong phylogenetic structure
Authors: Strutzenberger Patrick , Fiedler Konrad 
Published: October 2021

AbstractPhylogenetic diversity metrics have been used to tackle an increasing number of questions in ecology and evolutionary biology. Here we present a novel use of phylogenetic diversity metrics namely the investigation of insect herbivore assemblages on select plant species in order to investigate possible drivers shaping the phylogenetic structure of those assemblages.We investigated the phylogenetic structure of lepidopteran herbivore assemblages on 208 species of central European vascular plants. A dataset of 2,553 species of Lepidoptera from 68 families, comprising 8,584 individual herbivore‐host associations, was analysed for patterns of phylogenetic α‐ and β‐diversity in relation to plant growth form, plant phylogeny and the accumulation of some characteristic major classes of secondary plant metabolites.Distinct patterns of phylogenetic β‐diversity were detected when plants were partitioned into three growth form categories (graminoid, herbaceous and woody). In contrast, groupings of plants according to higher taxa or key secondary metabolites did not yield similarly clear patterns. Notable exceptions were assemblages on graminoid plants, especially those containing silica, which could be distinguished by both plant phylogeny and their phytochemical characteristics. Additionally plants containing highly toxic glucosinolates (all of the family Brassicaceae) harbour highly distinct lepidopteran assemblages. Phylogenetic α‐diversity of associated caterpillars differed greatly between graminoid, herbaceous and woody plants. Assemblages on graminoid plants were found to be the most phylogenetically clustered, followed by herbs and woody plants which showed the least degree of phylogenetic clustering. In conclusion, our results indicate that the phylogenetic structure of the investigated herbivore assemblages in the nemoral and boreal zones of the Western Palaearctic region is most heavily influenced by plant growth form while categories derived from higher plant systematics or classifications reflecting secondary metabolites leave far less signal at this macroecological scale.The approach taken in this study proved to be very successful in identifying patterns in the phylogenetic structure of herbivore assemblages. Our findings are in line with the ‘classical’ plant apparency hypothesis. Plant secondary compounds were found to have only limited explanatory power on our scale of analysis.A freePlain Language Summarycan be found within the Supporting Information of this article.
POLYCENTRIC DEVELOPMENT AND THE FORMATION OF EDGE URBAN AREAS IN CHINA'S MEGA CITY REGIONS: Case Study of Nansha, Guangzhou
Authors: Cheng Hui , Shaw David 
Published: October 2021

AbstractTowards the end of the twentieth century, polycentricity was introduced into China as a new planning concept. Subsequently, a number of mega city regions applied polycentric spatial planning strategies, designed to facilitate more sustainable and balanced development, by promoting expanded settlements or subcentres at the edge of the central cities. These urban clusters have often been termed edge cities in the West. Although edge urban areas in China bear some resemblance to Western edge cities, we argue that these growing centres need to be understood through the lens of a polycentric development framework specific to China. This article investigates the formation of edge urban areas as part of polycentric development practices, with particular reference to the specificities of the Chinese context. Guangzhou, a mega city region, is selected as the polycentric context within which the embedded edge urban area Nansha is located. After exploring Nansha's spatial features, functional identities and governance arrangements, we suggest that the area has experienced a typical development trajectory associated with different dynamics at each stage of its growth. Nansha's formation as an edge urban area is in line with the delivery of a polycentric spatial structure for the Guangzhou mega city region.
Promoting green performance through green human resource practices and green servant leadership
Authors: Mansoor Adil , Farrukh Muhammad , Jahan Sarwat , Lee Jong‐Keon , Abd Wahab Sazali 
Published: October 2021

Previous studies have analysed the effect of human resource (HR) practices on organisational green performance. However, this study provides a more robust analysis by highlighting the synergetic impact of green HR practices and green organisational strategies (green management initiatives) on firms' environmental performance. Moreover, this research also identifies the role of green servant leadership (SL) in implementing green management initiatives, which has been overlooked previously. Using a sample of 272 employees working in Pakistani manufacturing firms and applying structural equation modelling technique, this research reveals that the combined impact of green HR practices and green strategies promotes green performance through green SL as a mediator. Therefore, the current study emphasises the need to have an integrative mechanism to enhance green performance. Besides, the intervening role of green SL suggests that managers must exhibit this style for the accomplishment of an organisational green agenda.
Metallurgical characterisation and torsional resistance of blue thermomechanically treated nickel titanium instruments after simulated ex vivo retreatment procedure
Authors: Kalyoncuoğlu Elif , Keskin Cangül , Keleş Ali , Aydemir Hikmet 
Published: October 2021

AbstractTo compare used and unused Reciproc Blue and Reciproc after retreatment, the instruments were used in the mesiobuccal canals of maxillary molars with curvature. The torsional resistances were tested and then unused instruments were subjected to XRD, DSC and microhardness tests. Student’s t, ANOVA and Tukey’s tests were performed (α‐level 0.05). The torsional strength of used Reciproc Blue was not significantly different than unused ones (P > .05), while torsional strength of Reciproc decreased significantly (P < .05). DSC and XRD indicated that Reciproc Blue exhibited prominent transformation peaks corresponding austenite to R‐phase. Microhardness of Reciproc was significantly higher (P < .05). A second reuse of Reciproc Blue for retreatment could be considered safe in terms of torsional strength. Blue treatment also decreased surface microhardness of the instrument and changed phase composition by increasing the R‐phase.
“Fests of Vests”: The Politics of Participation in Neoliberal Peacebuilding in Colombia
Authors: Vélez‐Torres Irene , Gough Katherine , Larrea‐Mejía James , Piccolino Giulia , Ruette‐Orihuela Krisna 
Published: October 2021

AbstractThe Colombian Peace Agreement signed in 2016 was saluted internationally by scholars, policy makers and practitioners for encompassing the concept of territorial peace as a means of ensuring local participation in the strengthening of state institutions. Based on engaged research conducted in the Department of Cauca and Bogotá between 2017 and 2020, we critically analyse territorial peace, exploring its ideation, implementation, and subsequent decline in favour of security and stabilisation. We argue that the government’s peacebuilding rationale and mechanisms sought to reinforce the neoliberal state through a constrained participation model, which marginalised the progressive struggles of local communities living in former conflict affected areas. Without a radical breakdown of pre‐existing power structures of exploitation and domination, community participation in peacebuilding runs the risk of legitimising state‐led initiatives that ensure the political rule of capital, strengthen the bureaucracies of the centralised state, and create new violent disputes without resolving existing ones.
The arrival time of indocyanine green in tissues can be a quantitative index because of its correlation with tissue oxygen saturation: A clinical pilot study
Authors: Egi Hiroyuki , Ohnishi Kazuho , Akita Satoshi , Sugishita Hiroki , Ogi Yusuke , Yoshida Motohira , Koga Shigehiro , Kikuchi Satoshi , Matsumoto Hironori , Kuwabara Jun , Matsui Sayuri , Ishimaru Kei , Hattori Minoru , Watanabe Yuji 
Published: October 2021

AbstractIndocyanine green (ICG) fluorescence angiography has recently been reported useful as a method for predicting intestinal blood flow and may reduce anastomotic leakage. However, the quantification method for ICG fluorescence angiography has not been established. We usually measure the tissue oxygen saturation (StO2) in the intestinal tract via near‐infrared spectroscopy, as it is able to measure the oxygen concentration accurately and immediately shows objective data. In this study, we propose that the time to reach the anastomotic site after intravenous ICG injection is an effective parameter for quantifying ICG fluorescence angiography from the comparison to the data of StO2 in the intestinal tract.
The biomechanical profile of an osseo‐integrated rectangular block implant: A pilot in vivo experimental study
Authors: Gazelakis Efthimios , Judge Roy B. , Palamara Joseph E. A. 
Published: October 2021

AbstractObjectiveA novel implant design, the rectangular block implant (RBI), was investigated as a possible solution to the restoration of the posterior resorbed ridge.AimTo maximally load test the osseo‐integrated RBI in shear and tensile loads and relate these findings to known human masticatory loads as biomechanical proof of the study concept.Materials and methodsTwelve RBIs were design‐manufactured and placed into posterior mandibular saddles in 3 mature greyhound dogs.—2 per left and right. After 12 weeks of healing, osseo‐integration was confirmed using resonance frequency analysis (RFA) and wrench torque tests. Three bone blocks each with two RBIs were dissected and mounted in acrylic. Micro‐computerized tomography (μ‐CT) was performed to assess bone to implant contact (BIC), and load analysis was performed using a Universal Test System. Three force applications were conducted until failure: pull‐out (tensile), buccal push from the lingual (shear) and distal push from the mesial (shear). The osteotomy sites were examined using light magnification and scanning electron microscopy (SEM).ResultsPull‐out, buccal and distal force failures occurred at differing levels. Post‐detachment sites showed complex patterns of bone failure, including trabecular and cortical fracture, as well as shearing at varying distances from the BIC. Interfacial shear strength was calculated at 14.4 MPa.ConclusionThe osseo‐integrated RBIs were able to withstand simulations of the demanding axially, bucco‐lingually and mesio‐distally oriented biomechanical challenges of the posterior saddle, under conditions of reduced bone volume. These values exceeded equivalent force components of maximal masticatory loads in humans.
Clinician and patient attitudes toward use of organs from hepatitis C viremic donors and their impact on acceptance: A contemporary review
Authors: Fleetwood Vidya A. , Maher Kennan , Satish Sangeeta , Varma C. Rathna , Nazzal Mustafa , Randall Henry , Al‐Adra David P. , Caliskan Yasar , Bastani Bahar , Rub Fadee Abu Al , Lentine Krista L. 
Published: October 2021

AbstractBackgroundThe use of Hepatitis C (HCV) NAT positive allografts remains unusual and is clustered at few centers. We conducted a contemporary literature review to assess whether patient and clinician attitudes toward viremic organs impact acceptance.MethodsDatabases including PubMed, MEDLINE, and SCOPUS databases were reviewed to identify studies focused on evaluating patient and provider perceptions of HCV NAT positive organ use within the DAA era (January 2015–April 2021). Search included MeSH terms related to Hepatitis C, transplantation, and patient and clinician attitudes. Two investigators extracted study characteristics including information on willingness to accept viremic organs, HCV‐specific outcomes knowledge, HCV‐specific concerns, and factors that contributed to acceptance or non‐acceptance.ResultsEight studies met all inclusion criteria. These included three pretransplant patient‐directed studies, two post‐transplant patient‐directed studies, one pre‐ and post‐transplant patient‐directed study, and two clinician‐directed studies. Common themes identified were concerns regarding HCV cure rates, viremic organ quality, DAA cost, stigma, and the possibility of HCV transmission to household members. The perception of decreased waitlist time was associated with viremic organ acceptance. Physician trust played a mixed role in acceptance patterns.ConclusionsKnowledge of high cure rates, shorter waitlist times, and higher organ quality appear to have the highest impact on organ acceptance.