bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice
Authors: Greiten Lawrence E. , Zhang Bin , Roos Carolyn M. , Hagler Michael , Jahns Fritz-Patrick , Miller Jordan D. 
Published: October 2021

Objective: Sirtuin deacetylases are major regulators of organismal aging, and while depletion of sirtuin 6 (SIRT6) in mice results in a profound progeroid phenotype, the role of SIRT6 in the regulation of vasomotor function is unknown. Thus, our objective was to test the hypothesis that reductions in SIRT6 elicit endothelial dysfunction in young, genetically altered mice.Results and Approach: We used young (3 month old), littermate-matched, SIRT6 wild-type (WT), and SIRT6 heterozygous (HET) mice. SIRT6 expression (qRT-PCR) was reduced by 50% in HET mice. Carotid vessel responses to acetylcholine, sodium nitroprusside, U46619, and serotonin were examined in isolated organ chamber baths. Relaxation in response to acetylcholine (ACH) was impaired in HET mice compared to littermate-matched WT controls (67 ± 3% versus 76 ± 3%, respectively; p &lt; 0.05), while responses to sodium nitroprusside were unchanged. Short-term incubation of carotid rings with the NAD(P)H oxidase inhibitor, apocynin, significantly improved in vessels from HET mice but not their WT littermates. Peak tension generated in response to either U46619 or serotonin was significantly blunted in HET mice compared to their WT littermates.Conclusion: These data suggest that SIRT6 is a key regulator of vasomotor function in conduit vessels. More specifically, we propose that SIRT6 serves as a tonic suppressor of NAD(P)H oxidase expression and activation, as inhibition of NAD(P)H oxidase improved endothelial function in SIRT6 haploinsufficient mice. Collectively, SIRT6 activation and/or histone acetyltransferase inhibition may be useful therapeutic approaches to reduce endothelial dysfunction and combat age-associated cardiovascular disease.
The Role of Mitochondria in Acute Kidney Injury and Chronic Kidney Disease and Its Therapeutic Potential
Authors: Zhang Xiaoqin , Agborbesong Ewud , Li Xiaogang 
Published: October 2021

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species (ROS) generation, and cell differentiation and death. Mitochondrial dysfunction has been recognized as a contributor in many diseases. The kidney is an organ enriched in mitochondria and with high energy demand in the human body. Recent studies have been focusing on how mitochondrial dysfunction contributes to the pathogenesis of different forms of kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD). AKI has been linked to an increased risk of developing CKD. AKI and CKD have a broad clinical syndrome and a substantial impact on morbidity and mortality, encompassing various etiologies and representing important challenges for global public health. Renal mitochondrial disorders are a common feature of diverse forms of AKI and CKD, which result from defects in mitochondrial structure, dynamics, and biogenesis as well as crosstalk of mitochondria with other organelles. Persistent dysregulation of mitochondrial homeostasis in AKI and CKD affects diverse cellular pathways, leading to an increase in renal microvascular loss, oxidative stress, apoptosis, and eventually renal failure. It is important to understand the cellular and molecular events that govern mitochondria functions and pathophysiology in AKI and CKD, which should facilitate the development of novel therapeutic strategies. This review provides an overview of the molecular insights of the mitochondria and the specific pathogenic mechanisms of mitochondrial dysfunction in the progression of AKI, CKD, and AKI to CKD transition. We also discuss the possible beneficial effects of mitochondrial-targeted therapeutic agents for the treatment of mitochondrial dysfunction-mediated AKI and CKD, which may translate into therapeutic options to ameliorate renal injury and delay the progression of these kidney diseases.
Generation of coaxial vortex beams with doubled topological charges using a stacked liquid crystal structure
Authors: Tsukamoto Yuji , Yoshida Hiroyuki , Ozaki Masanori 
Published: October 2021

Abstract
Optical vortices (OVs), which carry orbital angular momenta are attractive for many optical applications. A facile means of generating OVs is through the use of q-plates, which are patterned liquid crystal (LC) waveplates. However, they are limited to generating beams with topological charge ±

ℓ
.

In this work, we propose a stacked LC structure consisting of patterned nematic LC with 1/4-wave retardation and planar cholesteric LC, and demonstrate its capability to generate coaxial OVs with topological charges

ℓ

and

2
ℓ

.

As an extension of the function of conventional q-plate, this structure provides large degree of freedom in the generating OVs.
The MOSDEF-LRIS Survey: Probing the ISM/CGM Structure of Star-forming Galaxies at z ∼ 2 Using Rest-UV Spectroscopy
Authors: Du 杜 Xinnan 辛楠 , Shapley Alice E. , Topping Michael W. , Reddy Naveen A. , Sanders Ryan L. , Coil Alison L. , Kriek Mariska , Mobasher Bahram , Siana Brian 
Published: October 2021

Abstract
The complex structure of gas, metals, and dust in the interstellar and circumgalactic medium (ISM and CGM, respectively) in star-forming galaxies can be probed by Lyα emission and absorption, low-ionization interstellar (LIS) metal absorption, and dust reddening E(B − V). We present a statistical analysis of the mutual correlations among Lyα equivalent width (EWLyα
), LIS equivalent width (EWLIS), and E(B − V) in a sample of 157 star-forming galaxies at z ∼ 2.3. With measurements obtained from individual deep rest-UV spectra and spectral energy distribution modeling, we find that the tightest correlation exists between EWLIS and E(B − V), although correlations among all three parameters are statistically significant. These results signal a direct connection between dust and metal-enriched H i gas and that they are likely cospatial. By comparing our results with the predictions of different ISM/CGM models, we favor a dusty ISM/CGM model where dust resides in H i gas clumps and Lyα photons escape through the low H i covering fraction/column density intraclump medium. Finally, we investigate the factors that potentially contribute to the intrinsic scatter in the correlations studied in this work, including metallicity, outflow kinematics, Lyα production efficiency, and slit loss. Specifically, we find evidence that scatter in the relationship between EWLyα
and E(B − V) reflects the variation in the metal–to–H i covering fraction ratio as a function of metallicity and the effects of outflows on the porosity of the ISM/CGM. Future simulations incorporating star formation feedback and the radiative transfer of Lyα photons will provide key constraints on the spatial distributions of neutral hydrogen gas and dust in the ISM/CGM structure.
New Light Curves of LP133-373 Reveal Flaring, A Refined Period and an Initial Epoch
Authors: Terracciano N. , Vaccaro T. 
Published: October 2021

Abstract
We present new CCD Johnson V and Cousins R photometric data on the eclipsing binary LP133-373. Analysis includes the detection of a flare event, eclipse timings and a refined period and initial epoch for the system. The new ephemeris for this system is T = 2452760.70523 ± 0.00045 + 1.6279850 ± 4.3805144 × 10−7 × e. Previous studies by others have mentioned period changes and radial velocity changes over time, so we continue to monitor LP133-373.
The Dark Side of Pluto
Authors: Lauer Tod R. , Spencer John R. , Bertrand Tanguy , Beyer Ross A. , Runyon Kirby D, , L White Oliver , Young Leslie A. , Ennico Kimberly , McKinnon William B. , Moore Jeffrey M. , Olkin Catherine B. , Stern S. Alan , Weaver Harold A. 
Published: October 2021

Abstract
During its departure from Pluto, New Horizons used its LORRI camera to image a portion of Pluto’s southern hemisphere that was in a decades-long seasonal winter darkness, but still very faintly illuminated by sunlight reflected by Charon. Recovery of this faint signal was technically challenging. The bright ring of sunlight forward-scattered by haze in the Plutonian atmosphere encircling the nightside hemisphere was severely overexposed, defeating the standard smeared-charge removal required for LORRI images. Reconstruction of the overexposed portions of the raw images, however, allowed adequate corrections to be accomplished. The small solar elongation of Pluto during the departure phase also generated a complex scattered-sunlight background in the images that was three orders of magnitude stronger than the estimated Charon-light flux (the Charon-light flux is similar to the flux of moonlight on Earth a few days before first quarter). A model background image was constructed for each Pluto image based on principal component analysis applied to an ensemble of scattered-sunlight images taken at identical Sun−spacecraft geometry to the Pluto images. The recovered Charon-light image revealed a high-albedo region in the southern hemisphere. We argue that this may be a regional deposit of N2 or CH4 ice. The Charon-light image also shows that the south polar region currently has markedly lower albedo than the north polar region of Pluto, which may reflect the sublimation of N2 ice or the deposition of haze particulates during the recent southern summer.
New Spain’s Cartography within Global Geography: José Antonio de Alzate’s Maps of North America
Authors: García Redondo José María 
Published: October 2021

Several printed versions of José Antonio de Alzate’s Nuevo Mapa Geográphico de la América Septentrional (1768) are known to exist. Despite his progressive changes to the map, the Mexican polymath saw it as a single “cartographic model” that he perfected over time. This article analyses his sources and working methods, as well as his contacts with other authors in New Spain and Europe. By distinguishing between mechanisms of passive and active circulation of both resources and cartographic methods, we can note an apparent change in Alzate’s practice, one which was stimulated by his interaction with, adaptation to and integration into a global geographical context.
Juarez and Maximilian. Stories and interpretations in film and literature
Authors: Morales Zea María del Sol 
Published: October 2021

This paper approaches the relations between history and fiction through analysis of two works: the Franz Werfel drama’s Juarez und Maximilian (1924), and the Miguel Contreras Torres movie’s, Juárez y Maximiliano (1934). Both works intend to tell us the happened during the Second Mexican Empire, Werfel with the Austrian gaze and Contreras with the Mexican gaze. We go inside to biography and context of authors, as well as the reception of the drama and movie in the local press, to understanding the political implications of the representations of the past. Finally, we analyze the philosophy of history implied in both Werfel and Contreras, and your relations with creation’s context.
Amaravati, une capitale pour l’Andhra Pradesh : construction et déconstruction d’un « projet de ville »
Authors: Jammet Louise 
Published: October 2021

Comment planifier et construire une nouvelle capitale d’État fédéré lorsque les mandats électoraux ne dépassent pas cinq années ? C’est l’équation que pose le cas du nouvel État d’Andhra Pradesh redessiné après une partition territoriale en 2013 qui a vu naître le Telangana et qui lui ampute Hyderabad, sa capitale et fleuron économique. Le premier Ministre en chef élu de l’Andhra Pradesh résiduel, N. C. Naidu, entreprend la construction d’Amaravati, une ville ex nihilo, dès 2014 pour combler le besoin de capitale mais l’alternance politique survenue en 2019 déstabilise l’ambition initiale du « projet de ville » au risque de la réduire en cendres. Ce cas d’étude éclaire les liens tissés entre aménagement du territoire et programmes politiques et les implications de leurs échecs.
L’Aventure olympique. Les architectures des Jeux d’hiver d’Albertville 1992 : des projets inaboutis ?
Authors: Beauvalet-Boutouyrie Marie 
Published: October 2021

Les architectures olympiques, du fait de leur complexité, constituent un cas d’étude intéressant pour étudier les échecs et les déréalisations de projets. C’est le cas à Albertville 1992 où les enjeux politiques, économiques et territoriaux l’ont emporté sur l’architecture. Bien que cet événement ait représenté une réelle occasion de produire des architectures marquantes et de qualité, cette opportunité semble avoir été « négligée » dès la candidature. Que ce soit par un manque de considération ou par des décisions contestables de la part de la maîtrise d’ouvrage (comité d’organisation des Jeux et communes) sur les sites des épreuves, les projets ont été malmenés pour aboutir à des architectures olympiques parfois mutilées et souvent oubliées. L’exemple du projet central que constitue la Halle de Glace d’Albertville est à ce titre le plus évocateur.
Preoperative Psychosocial Factors and Short-term Pain and Functional Recovery After Hip Arthroscopy for Femoroacetabular Impingement Syndrome
Authors: Jochimsen Kate N. , Noehren Brian , Mattacola Carl G. , Di Stasi Stephanie , Duncan Stephen T. , Jacobs Cale 
Published: October 2021

Context
Low mental health scores, depression, and anxiety are associated with worse pain and functional outcomes after hip arthroscopy for patients with femoroacetabular impingement syndrome (FAIS). Preoperative screening of psychosocial factors such as self-efficacy, kinesiophobia, and pain catastrophizing may further aid in identifying patients at risk for poorer outcomes.

Objective
To compare preoperative function and psychosocial factors between patients with and those without elevated postoperative pain 3 months after hip arthroscopy for FAIS.

Design
Prospective cohort study.

Setting
University health center.

Patients or Other Participants
Fifty-one individuals with FAIS (41 women, 10 men; age = 37.6 ± 12.3 years, body mass index = 27.1 ± 4.1 kg/m2).

Main Outcome Measure(s)
Preoperatively, participants completed the Pain Self-Efficacy Questionnaire (PSEQ), Tampa Scale for Kinesiophobia (TSK), Pain Catastrophizing Scale (PCS), 12-Item International Hip Outcome Tool (iHOT-12), and a 10-point visual analog scale (VAS) for hip pain at rest and during activity. Three months postoperatively, they completed the PSEQ, TSK, PCS, iHOT-12, and VAS. Preoperative scores were compared between those with (VAS ≥ 3) and those without (VAS &lt; 3) elevated postoperative pain using Mann-Whitney U tests, and odds ratios were calculated to determine the odds of having elevated postoperative pain and lower postoperative function.

Results
Participants with elevated postoperative pain at rest and during activity had worse preoperative psychosocial health (P ≤ .04). Those with elevated postoperative pain at rest had worse preoperative function (P &lt; .001). The odds of having elevated postoperative pain at rest were 45 times and 4.5 times higher for those with low self-efficacy and high pain catastrophizing, respectively (P values ≤ .03). The odds of having elevated postoperative pain during activity were 7.1, 6.2, and 3.5 times higher for those with low self-efficacy, high kinesiophobia, and high pain catastrophizing, respectively (P values ≤ .04). The odds of having lower postoperative iHOT-12 scores were 7.5 and 14.0 times higher for those with high kinesiophobia and pain catastrophizing, respectively (P values ≤ .03).

Conclusions
Poor preoperative psychosocial health increased the odds of elevated pain and worse function 3 months after hip arthroscopy for FAIS. This is a first step in identifying the psychosocial factors that may contribute to poorer long-term hip arthroscopy outcomes.
Alimento Funcional: Uma Nova Abordagem Terapêutica das Dislipidemias como Prevenção da Doença Aterosclerótica
Authors: Braga Adriana D‘Auria Aparecida , Barleta Valéria Calmeto Noronha 
Published: October 2021

A nutrição é uma das ciências mais antigas que visa estudar o alimento e as modificações que este sofre ao passar pelo organismo. No Japão na década de 80, estudos comprovaram que certos alimentos além de suas funções básicas nutricionais demonstraram benefícios fisiológicos e reduziram o risco de doenças; foram denominados alimentos funcionais, que podem potencialmente reduzir a ocorrência de doenças cardiovasculares, cânceres, osteoporose, problemas intestinais. A associação Americana do Coração já indica o uso de alimentos funcionais como parte da dieta para dislipidemias, o principal fator desencadeador da aterosclerose. As doenças cardiovasculares lideram o índice de mortalidade no Brasil, e são responsáveis por 50% das mortes nos EUA. Os principais compostos ativos responsáveis pelas ações preventivas das doenças cardiovasculares pertencem ao grupo dos polifenóis (flavonóides e isoflavonas), carotenóides e ômega–3; encontrados em alimentos usuais como: alho, tomate, berinjela, chocolate amargo, uva - vinho tinto, peixe, oleaginosas, chá verde, soja, especiarias, leguminosas, cogumelos e maçã. Hoje os alimentos com atividade funcional fazem parte da nutrição aplicada no dia-a-dia de muitos nutricionistas, nas mais diversas atividades,exigindo do profissional um aprofundamento na ciência dos compostos funcionais.
Influência da Precipitação da Fase ω na Dureza das Ligas Ti-10Mo-20Nb E Ti-12Mo-13Nb
Authors: Mansur Laiz Silva , Torres Juliana , Almeida Luiz Henrique de , Nunes Carlos Angelo , Santos Iranildes dos , Gabriel Sinara Borborema 
Published: October 2021

Ligas de Ti, do tipo β tem sido desenvolvidas para aplicação biomédica. As vantagens destas ligas incluem seu baixo módulo de elasticidade, boa compatibilidade mecânica e, além disso, as variáveis de processamento podem ser controladas para obter propriedades desejadas. As ligas de Ti-β, na condição metaestável, podem ser fortemente endurecidas por precipitação de fases após envelhecimento. Várias microestruturas podem ser obtidas por diferentes tratamentos de envelhecimento os quais influenciam várias propriedades das ligas Diante do contexto, o objetivo deste trabalho foi estudar a influência da precipitação da fase ω na dureza das ligas Ti-10Mo-20Nb e Ti-12Mo-13Nb. O material nas diferentes condições foi caracterizado por difração de raios X e medida de microdureza. Os resultados mostraram que a precipitação da fase ω durante o envelhecimento acarretou no aumento da dureza das ligas Ti-10Mo-20Nb e Ti-12Mo-13Nb. Observou-se uma tendência da liga Ti-12Mo-13Nb apresentar os maiores valores de dureza. Ligas de Ti, do tipo β tem sido desenvolvidas para aplicação biomédica. As vantagens destas ligas incluem seu baixo módulo de elasticidade, boa compatibilidade mecânica e, além disso, as variáveis de processamento podem ser controladas para obter propriedades desejadas. As ligas de Ti-β, na condição metaestável, podem ser fortemente endurecidas por precipitação de fases após envelhecimento. Várias microestruturas podem ser obtidas por diferentes tratamentos de envelhecimento os quais influenciam várias propriedades das ligas Diante do contexto, o objetivo deste trabalho foi estudar a influência da precipitação da fase ω na dureza das ligas Ti-10Mo-20Nb e Ti-12Mo-13Nb.O material nas diferentes condições foi caracterizado por difração de raios X e medida de microdureza. Os resultados mostraram que a precipitação da fase ω durante o envelhecimento acarretou no aumento da dureza das ligas Ti-10Mo-20Nb e Ti-12Mo-13Nb. Observou-se uma tendência da liga Ti-12Mo-13Nb apresentar os maiores valores de dureza.
Análise do comportamento da força de aderência de um ajuste prensado em rodas de aço ABNT 4340
Authors: Martins Celso Luiz Azevedo , Ribeiro Rosinei Batista , RAymundo Emerson Augusto 
Published: October 2021

Esta pesquisaconfirmou, por meio de resultados experimentais, que nos ajustes prensadosentre peças de aço, a força de aderência aumenta muito nos primeiros dias apósa montagem e segue aumentando lentamente ao longo do tempo. Os conjuntosroda-eixo foram montados e desmontados com a utilização de uma máquinauniversal hidráulica de ensaios mecânicos. As desmontagens foram realizadas emsequência, após períodos que variaram entre a primeira hora até quarenta e um (41) dias após montagem. Destemodo, foi possível verificar o aumento da força necessária para desmontagemdecorrente do tempo entre a montagem e a desmontagem.
Impact of Infrared Atmospheric Sounding Interferometer (IASI) thermal infrared measurements on global ozone reanalyses
Authors: Emili Emanuele , El Aabaribaoune Mohammad 
Published: October 2021

Abstract. The information content of thermal infrared measurements for tropospheric ozone (O3) estimation has already been well demonstrated. However, the impact of such measurements to constrain modelled O3 distributions within global assimilation systems is not yet unequivocal. A new tropospheric O3 reanalysis is computed for the year 2010 by means of assimilating measurements from the Infrared Atmospheric Sounding Interferometer (IASI) within the MOdéle pour la Chimie Á Grande Echelle (MOCAGE) chemical transport model. The objective is to evaluate the impact of recent methodological improvements of the data assimilation scheme on the O3 distribution. The new O3 reanalysis (named IASI-r) and its precursor (IASI-a) have been validated against ozonesondes, and compared to independent estimations of tropospheric O3 and to results from two state-of-the-art products based on detailed tropospheric chemistry (the Goddard Earth Observing System with a coupled chemistry–climate model, GEOS-CCM, and the Copernicus Atmosphere Monitoring Service, CAMS, reanalysis). The main difference between IASI-r and IASI-a concerns the treatment of IASI observations, with radiances being assimilated directly in IASI-r instead of intermediate Level 2 O3 retrievals. IASI-r is found to correct major issues with IASI-a, such as the neutral or negative impact of IASI assimilation in the extra-tropics and the presence of residual biases in the tropics. IASI-r also compares relatively well to the CAMS reanalysis, which is based on a more comprehensive chemical mechanism and the assimilation of several ultraviolet (UV) and microwave measurements.