bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk and protective factors for acute mountain sickness: a meta-analysis
Authors: Recalde Sergio , Alargunsoro Leire , Milagro Fermin I. , Ibañez Ricardo , Villegas Andrea , Sáez Victor J. , Cires Manuel , Garcia-Garcia Laura 
Published: August 2021

Abstract
BackgroundCurrently, many people reach 3000-meter summits or greater. Some of these climbers suffer from acute mountain sickness (AMS), while others remain symptom-free. Some risk factors for AMS are well defined, such as lack of pre-acclimatization, rapid ascent, maximum altitude, and resilience at low altitude. However, there are other poorly described associated factors, such as sex, age, smoking, body mass index, medication use, and awareness or history of AMS. The objective of this meta-analysis was to establish the risk and protective factors associated with AMS. MethodsPubMed, UNIKA, and Scopus databases were searched in July 2020 for articles to include in the analysis. AMS was separately evaluated by the Lake Louise Score (LLS) and Hackett’s Score (HS). After screening and application of eligibility criteria, 14 articles were included in the meta-analysis (LLS = 12 and HS = 2). ResultsA total of 18,938 participants were included in the study with 17,450 in the LLS group and 1,488 in the HS group. In the LLS group, smoking (odds ratio [OR] 0.76 [0.63-0.92]; χ2 = 10.3; I2 = 61.2%), history of AMS (OR 1.16 [1.03-1.32]; χ2 = 12.2; I2 = 67%), altitude preexposure (OR 0.68 [0.5-0.91]; χ2 = 22.21; I2 = 82%; τ2 = 0.06), and maximum altitude (OR 2.01 (1.07-3.77) (χ2 = 19.15. I2 = 89.6%. τ2 = 0.26) were statistically significant. In the HS group, age >35 years (OR 0.72 [0.52-0.99]; χ2 = 2.14; I2 = 6.7%) and a history of AMS (OR 8.2 [3.28-20.54]; χ2 = 3.7; I2 = 73%; τ2 = 0.32) were found to be statistically significant. ConclusionsThis study suggests that younger age, non-smoking, history of AMS, nonacclimatization, and hiking to a high maximum altitude (>2500m) increases the possibility of suffering from AMS.
An efficient inverse method for structural identification considering modeling and response uncertainties
Authors: Cao Lixiong , Liu Jie , Lu Cheng , Wang Wei 
Published: August 2021

Abstract
The inverse problem analysis method provides an effective way for the structural parameter identification. Due to the coupling of multi-source uncertainties in the measured responses and the modeling parameters, the inverse of unknown structural parameter will face the challenges in the solving mechanism and the computational cost. In this paper, an uncertain inverse method based on convex model and dimension reduction decomposition is proposed to realize the interval identification of unknown structural parameter according to the uncertain measured responses and modeling parameters. Firstly, the polygonal convex set model is established to quantify the uncertainties of modeling parameters. Afterwards, a space collocation method based on dimension reduction decomposition is proposed to transform the inverse problem considering multi-source uncertainties into a few interval inverse problems considering response uncertainty. The transformed interval inverse problem involves the two-layer solving process including interval propagation and optimization updating. In order to solve the interval inverse problems considering response uncertainty, an efficient interval inverse method based on the high dimensional model representation and affine algorithm is further developed. Through the coupling of the above two methods, the proposed uncertain inverse method avoids the time-consuming multi-layer nested calculation procedure, and then effectively realize the inverse uncertainty quantification of unknown structural parameters. Finally, two engineering examples are provided to verify the effectiveness of the proposed uncertain inverse method.
Risk Factors for Postoperative Ileus after Diverting Loop Ileostomy Closure following Rectal Cancer Surgery: A Retrospective Study
Authors: Nakao Toshihiro , Shimada Mitsuo , Yoshikawa Kozo , Tokunaga Takuya , Nishi Masaaki , Kashihara Hideya , Takasu Chie , Wada Yuma , Yoshimoto Toshiaki , Yamashita Syoko , Iwakawa Yosuke 
Published: August 2021

Abstract
Background: Postoperative ileus is one of the most common complications after diverting loop ileostomy closure. Some reports have investigated the risk factors for postoperative complications or ileus after ileostomy closure; however, these studies did not evaluate the index surgery sufficiently. In this study, we evaluated the risk factors, including the details of the index surgery, for ileus after diverting ileostomy closure.Methods: This was a retrospective study of patients who underwent ileostomy closure following index surgery for rectal cancer. Patients who developed postoperative ileus (POI (+)) and patients who did not (POI (−)) after ileostomy closure were compared.Results: Fifty-nine patients were evaluated and were divided into two groups: POI (+) (n=9) and POI (−) (n=50), and the groups were compared. There were no significant differences in the details of the index surgery, operative procedure, transanal total mesorectal excision, lateral lymph node dissection, operating time, or blood loss. The incidence of Clavien–Dindo grade ≥ III complications after the index surgery was significantly higher in the POI (+) group. Conclusions: The incidence of Clavien–Dindo grade ≥ III complications after the index surgery may increase the risk of postoperative ileus after ileostomy closure.
Clinical Benefits of Early Concurrent use of Cryoprecipitate and Plasma Compared with Plasma only in Bleeding Trauma Patients: Analysis of the Trauma Quality Improvement Program Database
Authors: Endo Akira , Senda Atsushi , Otomo Yasuhiro , Coimbra Raul 
Published: August 2021

Abstract
Background:The effectiveness of cryoprecipitate in trauma has not been well-established. In addition, the benefits of cryoprecipitate might have been overestimated in previous studies since the difference in the total amount of administered clotting factors was not considered. This study aimed to evaluate the benefits of the concurrent use of cryoprecipitate in combination with fresh frozen plasma (FFP) during the resuscitation of bleeding trauma patients.Methods: A retrospective cohort study using the American College of Surgeons Trauma Quality Improvement Program database was conducted. Patients who received ≥4 units of packed red blood cells within the first 4 hours after arrival to the emergency department (ED) were dichotomized according to whether cryoprecipitate was used. The outcomes (primary: in-hospital mortality; secondary: 24-h mortality and incidence of complications) were compared using propensity score-matching analysis, in which the amount of total administered clotting factors was balanced.Results: A total of 19,008 patients (Cryo+FFP group: 3825; FFP only group: 15,183) were eligible for analysis, of whom 3103 propensity score-matched pairs were generated. Significantly lower in-hospital mortality (1217 [39.2%] patients in the Cryo+FFP group vs. 1295 [41.7%] in the FFP only group; odds ratio [OR], 0.90; 95% CI, 0.81-1.00) and 24-h mortality (735 [23.7%] vs. 886 [28.6%]; OR, 0.78; 95% CI, 0.69-0.87) were observed in the Cryo+FFP group than in the FFP only group; no significant difference was observed in the incidence of complications. Conclusions: Cryoprecipitate use combined with FFP was significantly associated with reduced mortality in bleeding trauma patients after adjustments were made for the dose of administered clotting factors. Future randomized controlled trials are warranted to confirm our results.
Efficacy and Safety of Radiofrequency Ablation Versus Video-assisted Thoracoscopic Sympathectomy in Palmar Hyperhidrosis: A Multicenter Cohort Study
Authors: Zhong Yiyue , Zhu Yanwen , Li Jiayan , Yang Xiaowei , Feng Zhiying , Liu Haipeng , Liang Zhu , Lin Baoquan , Liu Zhifeng , Wang Xin , Luo Weibin , Zhu Jian , Li Bin , Lai Shangdao , Jiang Weize , Wu Jiayuan , Li Daheng , Zhang Liangqing , Huang Bing , Tang Jing 
Published: August 2021

Abstract
Background: Radiofrequency ablation (RFA) was adopted as an alternative to surgical options for sympathectomy in patients with palmar hyperhidrosis (PHH), but the RFA comparative efficacy of treatments by video-assisted thoracoscopic sympathectomy (VATS) on long-term remains uncertain.Methods: We recruited patients aged ≥14 years with diagnosed PHH from 14 centers in China. The treatment options of RFA or VATS were recruited in patient with informed consent. The primary outcome was the clinical efficacy in 1-year. Propensity scoring and multivariable models respectively were used to evaluate the clinical efficacy and inefficacy risk of treatment options.Results: A total of 807 patients were enrolled, 351 patients underwent RFA, and 456 were VATS. After propensity score matching, the rate of complete remission was lower in RFA than in VATS (79.2% [247/312] versus 91.3% [285/312], 95% confidence intervals [CI] 0.21 to 0.57, p<0.001). However, the rate of palmar dryness (95% CI 0.38 to 0.92, p=0.020), of postoperative pain (95% CI 0.13 to 0.33, p<0.001), and of surgical-related complication (95% CI 0.19 to 0.85, p=0.020) is lower in RFA group than in VATS group, and radiofrequency ablation group of skin temperature rise is more common (95% CI 1.84 to 3.58, p<0.001).Conclusion: Performing RFA had a lower success rate than VATS for the complete remission of palmar hyperhidrosis. However, RFA may be better reasonable treatment option for palmar hyperhidrosis before surgical sympathectomy, because it more possibly accepted and generalized due to lower symptomatic burden and costs than surgical sympathectomy in patients.Trial RegistrationChiCTR2000039576, URL: http://www.chictr.org.cn/index.aspx
The Correlation Between Nutrition and Frailty and the Predictive Value of Different Nutritional Indexes for Frailty
Authors: Liang Hong , Li Xiaoping , Lin Xiaoye , Ju Yanmin , Leng Jiyan 
Published: August 2021

Abstract
Background: Frailty is a kind of geriatric syndrome, which is very common in the elderly. Patients with malnutrition are at higher risk of frailty. This study analyzes the risk factors of frailty and the predictive value of different indicators for the occurrence of frailty through a cross-sectional study.Results: The study included 179 hospitalized patients aged 65 years and over. Patients were divided into non-frailty group and frailty group according to Fried Frailty Phenotype. Compared with the non-frailty group, the upper arm circumference, calf circumference, hemoglobin, albumin, prealbumin, cholesterol and low density lipoprotein in the frailty group were lower (P < 0.05). Comprehensive nutritional assessment, whether as a categorical variable or a continuous variable, was significantly correlated with frailty (P < 0.05). Model1 showed that the risk of frailty in malnourished patients was 3.381 times higher than that in well nourished patients (P = 0.036). Model2 showed that the risk of frailty decreased by 13.8% for every 1 point increase in MNA score (P = 0.009). The area under the curves of albumin, prealbumin and hemoglobin was larger (AUC > 0.65), AUC was 0.718, 0.693 and 0.743, respectively.Conclusions: Malnutrition is closely related to frailty. Albumin, prealbumin and hemoglobin have predictive value for frailty. Further cohort studies are needed to verify their ability to screen for frailty.
Proof of Space Transactions: A Novel Blockchain Protocol for Secure Authentication of Satellite Transactions
Authors: Hassanien Aboul Ella , Torky Mohamed , Goda Essam , Snasel Vaclav , Gaber Tarek 
Published: August 2021

Abstract
Blockchain technology can play a vital role in the space industry and satellite communication. This disruptive technology can build decentralized and secure protocols for processing and manipulating space transactions in the form of space digital tokens (SDTs). Tokenizing space transactions in the form of SDTs will enable various blockchain-based applications in the space industry. Moreover, blockchain protocols based on smart contracts can be utilized to authenticate many space transactions and P2P communications in a transparent, verifiable, and secure manner. This paper proposes a new blockchain-based solution for managing and securing satellite transactions using a novel concept called SDT. SDT is then used to develop a new blockchain protocol called proof of space transactions (PoST), which is then used in proposing a new blockchain-based protocol for authenticating satellite transactions. The proposed PoST protocol is implemented and simulated using the Ethereum blockchain. Five metrics are used to evaluate the protocol's performance: Ethereum GAZ, read latency, transaction latency, read throughput, and transaction throughput. The performance evaluation results proved the efficiency and reliability of PoST in managing and securing satellite transactions.
Fibular osteotomy is helpful for talar reduction in the treatment of varus ankle osteoarthritis with supramalleolar osteotomy
Authors: Liang Jing-Qi , Wang Jun-Hu , Zhang Yan , Wen Xiao-Dong , Liu Pei-Long , Liang Xiao-Jun , Lu Jun , Li Yi , Zhao Hong-Mou 
Published: August 2021

Abstract
Background

There have been debates on the necessity of fibular osteotomy (FO) in supramalleolar osteotomy (SMOT) for the treatment of varus ankle osteoarthritis. The purpose of the current study was to compare the clinical and radiological outcomes between SMOT with and without FO in the treatment of varus ankle osteoarthritis.
Methods

The SMOT group included 39 patients, and the SMOT with FO group included 24 patients. The basic information reached no significant difference between groups. The American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, Ankle Osteoarthritis Scale (AOS), modified Takakura stage and range of motion (ROM) were used for the functional evaluation. The radiologic parameters were assessed at the last follow-up to compare the degree of talar reduction between the two groups.
Results

Both groups achieved significant improvements in AOFAS scores, modified Takakura stage as well as AOS pain and functional scores (P༜0.001). The ROM of the ankle joint in the SMOT group was significantly decreased (P = 0.022). In both groups, all of the radiological parameters were significantly improved (P༜0.01). The tibiofibular clear space (TFCS) was significantly widened in the SMOT group (P༜0.001). No significant difference was found between the two groups according to the functional outcomes. However, the talar tilt angle (TT) and hindfoot alignment angle (HFA) in the SMOT with FO group were significantly smaller than those in the SMOT group (P༜0.05). The TFCS was significantly widened in the SMOT group (P = 0.001). The medial displacement of the talus (MDT) was better reduced in the SMOT with FO group (P = 0.006).
Conclusion

SMOT is a promising procedure for functional improvement and malalignment correction in varus ankle osteoarthritis but reduces ankle range of motion. If SMOT is combined with FO, talar tilt and medial displacement will be better reduced.
Discovering Biomarkers in Gastric Cancer by Urine Metabolomics
Authors: Kong Yuan , Zhang Hongya , Li Shuang , Suo Jian , Zhang Shaopeng , Li Jian , Yang Shaokang , Liu Zhifeng , Yang Peng , Li Qian , Wang Daguang 
Published: August 2021

Abstract
IntroductionGastric cancer is one of the most common gastrointestinal tumors, ranking forth in incidence and second in mortality worldwide. Discovering molecular biomarkers for early gastric cancer diagnosis is of great importance. MethodsUrine and related clinical data of 40 patients with gastric cancer (20 in advanced stage and 20 in early stage) and 20 healthy volunteers from Jilin University First Hospital were collected. Liquid chromatography-mass spectrometry (LC-MS) was used to detect urine samples and the metabolic differences between the three groups of urine samples were analyzed. The principal component analysis was performed after data processing, and different metabolites were found using analysis of variance. Partial least square discriminant analysis was performed to further narrow the range of different metabolites. The precise mass to charge ratios of different metabolites were imported into the Human Metabolomics Database (HMDB). Finally, the identified different metabolites were further screened by cluster analysis and ROC curve. ResultsUrine samples of the healthy group (NOR), the early gastric cancer group (EGC), and the advanced gastric cancer group (AGC) were different metabolites. 324 statistically significant metabolites are screened out. The cluster analysis showed 7-Methylguanine, vinylacetylglycine, butyric acid, 4-Vinylphenol sulf, 5`-biotinyl-AMP, and 3-Amino-2-piperido in EGC, AGC and NGO were similar. 7-Methylguanine, vinylacetylglycine and 4-Vinylphenolsulfate had good diagnostic ability in EGC and NOR (p<0.05), and gastric cancer and NOR (p<0.05). ConclusionDifferences in the metabolites in urine between the early gastric cancer group and the healthy group were found. 7-Methylguanine, Vinylacetylglycine, and 4-Vinylphenolsulfate have good diagnostic ability and may be potential biomarkers of early gastric cancer.
Study on Forming Characteristics of Natural Bulging Area of Metal Thin-walled Tube Under Liquid Impact Forming
Authors: Fan Xiangwen , Liu Jianwei , Xiao Zhu , Liang Huiping , Sun Changying , Tian Fengshou 
Published: August 2021

Abstract
Liquid Impact Forming (LIF) is a new composite forming technology based on Tube Hydroforming (THF) technology, which changes the volume of mould cavity through impact load and rapidly generates internal pressure to realize tube forming. It does not need external pressure supply source, and it is low cost and high efficiency. In order to study the forming characteristics of the natural bulging area of thin-walled metal tubes under different model side lengths and different model closing velocities, the change of the cavity volume of thin-walled metal tubes under impact hydraulic bulging was firstly analyzed theoretically, and a mathematical model of internal pressure was established. Then the effects of different loading parameters on the internal pressure, bulging height and wall thickness distribution in the natural bulging area of thin-walled metal tube were studied. Finally, through the comparison of finite element simulation analysis and experiment, it was found that the deviation between the experimental results and the numerical simulation was within 5%, which verified the accuracy and reliability of LIF. It also provides a certain theoretical research and application basis for the development of LIF of metal thin-walled tube.
An Atlas to Support the Progressive Control of Tsetse-transmitted Animal Trypanosomosis in Burkina Faso
Authors: Lassané Percoma , Rayaissé Jean Baptiste , Gimonneau Geoffrey , Bengaly Zakaria , Pooda Sié Hermann , Pagabeleguem Soumaila , Ganaba Rasmané , Sow Adama , Argilés Rafael , Bouyer Jérémy , Ouedraogo Moussa , Zhao Weining , Paone Massimo , Sidibé Issa , Gisele O/Sanon , Cecchi Giuliano 
Published: August 2021

Abstract
Background African animal trypanosomosis (AAT), transmitted by tsetse flies, is arguably the main disease constraint to integrated crop-livestock agriculture in sub-Saharan Africa, and African Heads of State and Government have adopted a resolution to rid the continent of this scourge. In order to sustainably reduce or eliminate the burden of AAT, a progressive and evidence-based approach is need, which must hinge on harmonized, spatially-explicit information on the occurrence of AAT and its vectors.MethodsA digital repository containing tsetse and AAT data collected in Burkina Faso between 1990 and 2019 was assembled. Data were collected either in the framework of control activities or for research purposes. Data were systematically verified, harmonized, georeferenced and integrated into a database (PostgreSQL). Entomological data on tsetse were mapped at the level of individual monitoring trap. When this was not possible, mapping done was at the level of site or location. Epidemiological data on AAT were mapped at the level of location/village.ResultsEntomological data showed that presence of four tsetse species in Burkina Faso. Glossina tachinoides was the most widespread and abundant species (56.35% of the catches), present from the eastern to the western part of the country. Glossina palpalis gambiensis was the second most abundant species (35.56%), and it was mainly found in the West. Glossina morsitans submorsitans was found at lower densities (6.11%), with a patchy distribution in the southern parts of the country. One only cluster of G. medicorum was detected (less than 0.1%), located in the Southwest. For the AAT component, data for 54,948 animal blood samples were assembled from 218 geographic locations. The samples were tested with a variety of diagnostic methods. AAT was found in all surveyed departments, including the tsetse-free areas in the North. Trypanosoma vivax and T. congolense infections were the dominant species 6.11±21.56% and 5.19±18.97% respectively), and to a lesser extend T. brucei infections (0.00±0.10%).Conclusions The atlas provides a synoptic view of the available information on tsetse and AAT distribution in Burkina Faso. Data are very scanty for most of the tsetse-free areas in the northern part of the country. Despite this limitation, this study generated a robust tool to aid the targeting of future surveillance and control activities. The development of the atlas also strengthened the collaboration between the different institutions involved in tsetse and AAT research and control in Burkina Faso, which will be crucial for future updates and the sustainability of the initiative.
Comparison of the Pregnancy and Neonatal Outcomes of ICSI Performed With Frozen Versus Fresh TESA Sperm in Patients With Obstructive Azoospermia: a Retrospective Study
Authors: Wu Shenghao , Xia Weiting , Xu Xin-Xin , Wu Yanhong , Hu Yangyang , Fang Lizi , Zhao Junzhao 
Published: August 2021

Abstract
BackgroundIt is commonly believed that using frozen sperms after TESA was effective for OA patients. Nevertheless, scholars are worried about the prognosis of ICSI with frozen testicular sperm. In this study, we aim to compare the pregnancy and neonatal outcomes of ICSI using cryopreserved versus fresh spermatozoa collected by TESA.MethodsA total of 317 cases of OA patients treated with ICSI in a university affiliated hospital from January 2016 to December 2020 were included in this retrospective study, and they were divided into two groups according to the sperm used for ICSI: Frozen sperm group (N=154) and Fresh sperm group(N=163). The outcomes were measured by the following indicators: Two pronucleus (2PN) fertilization rate, 2PN cleavage rate, high-quality blastocyst rate, average number of embryos transferred, implantation rate, clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, preterm birth rate, live birth rate (LBR) , sex ratio at birth (male) and average newborn birth weight.ResultsThe present data showed no statistically significant difference in 2PN fertilization rates, 2PN cleavage rates, high-quality blastocyst rates and the average number of embryos transferred in the two groups. Similarly, no difference was found in implantation rate, clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, premature delivery rate, LBR and sex ratio at birth (P>0.05). The average newborn birth weight was similar in the two groups (2932.61±728.40 vs 3100.32±515.64) (P>0.05), but there was a higher incidence of Low-Birth-Weight newborn in the frozen group (20.91% vs 8.49%)(P<0.05). ConclusionsAs for men with obstructive azoospermia, the use of frozen testicular sperm by TESA was efficient. There was a similar pregnancy outcome of ICSI using frozen or fresh spermatozoa collected by TESA. However, it may lead to higher incidence of newborns of low birth weight, which needs further research based on larger samples.