bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC01278 Sponges miR‐500b‐5p to Regulate the Expression of ACTG2 to Control Phenotypic Switching in Human Vascular Smooth Muscle Cells During Aortic Dissection
Authors: Wang Weitie , Liu Qing , Wang Yong , Piao Hulin , Zhu Zhicheng , Li Dan , Wang Tiance , Liu Kexiang 
Published: April 2021

Background
Phenotypic switching in vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of aortic dissection (AD). This study aims to explore the potential mechanisms of linc01278 during VSMC phenotypic switching.

Methods and Results

Twelve samples (6 AD and 6 control) were used for lncRNA, microRNA, and mRNA microarray analysis. We integrated the mRNA microarray data set with
GSE52093
to determine the differentially expressed genes. Bioinformatic analysis, including Gene Expression Omnibus 2R, Venn diagram analysis, gene ontology, pathway enrichment, and protein–protein interaction networks were used to identify the target lncRNA, microRNA, and mRNA involved in AD. Subsequently, we validated the bioinformatics data using techniques in molecular biology in human tissues and VSMCs. Linc01278, microRNA‐500b‐5p, and ACTG2 played an important role in the vascular smooth muscle contraction pathway. Linc01278 and ACTG2 were downregulated and miR‐500b‐5p was upregulated in AD tissues. Molecular markers of VSMC phenotypic switching, including SM22α, SMA, calponin, and MYH11, were downregulated in AD tissues. Plasmid‐based overexpression and RNA interference‐mediated downregulation of linc01278 weakened and enhanced VSMC proliferation and phenotypic switching, respectively. Dual‐luciferase reporter assays confirmed that linc01278 regulated miR‐500b‐5p that directly targeted ACTG2 in HEK293T cells.

Conclusions
These data demonstrate that linc01278 regulates ACTG2 to control the phenotypic switch in VSMCs by sponging miR‐500b‐5p. This linc01278‐miR‐500b‐5p‐ACTG2 axis has a potential role in developing diagnostic markers and therapeutic targets for AD.
Watching the Brain as It (Un)Binds: Beta Synchronization Relates to Distractor–Response Binding
Authors: Pastötter Bernhard , Moeller Birte , Frings Christian 
Published: April 2021

Abstract
Human action control relies on event files, that is, short-term stimulus–response bindings that result from the integration of perception and action. The present EEG study examined oscillatory brain activities related to the integration and disintegration of event files in the distractor–response binding (DRB) task, which relies on a sequential prime–probe structure with orthogonal variation of distractor and response relations between prime and probe. Behavioral results indicated a DRB effect in RTs, which was moderated by the duration of the response-stimulus interval (RSI) between prime response and probe stimulus onset. Indeed, a DRB effect was observed for a short RSI of 500 msec but not for a longer RSI of 2000 msec, indicating disintegration of event files over time. EEG results revealed a positive correlation between individual DRB in the RSI-2000 condition and postmovement beta synchronization after both prime and probe responses. Beamformer analysis localized this correlation effect to the middle occipital gyrus, which also showed highest coherency with precentral and inferior parietal brain regions. Together, these findings suggest that postmovement beta synchronization is a marker of event file disintegration, with the left middle occipital gyrus being a hub region for stimulus–response bindings in the visual DRB task.
The Challenge of Forging Consent to UN Mediation in Internationalized Civil Wars: The Case of Syria
Authors: Hellmüller Sara 
Published: April 2021

Abstract
This article analyzes how the internationalization of civil wars influences conflict parties’ consent to UN mediation processes. Illustrated by the UN mediation in Syria, I argue that internationalization influences consent directly by obstructing the advent of a costly stalemate and the parties’ perception of mediation as a ‘way out,’ and indirectly by reducing mediators’ leverage and perceived impartiality thereby limiting their tools to foster consent. The article makes three contributions. First, it presents a novel conceptual framework to understand the impact of internationalization on conflict parties’ consent. Second, it provides a long-term analysis of UN mediation in Syria from 2012–2020. Third, it contributes to a broader discussion about how civil wars end. This is of particular relevance as the prioritization of a political over a military end to civil wars, which was dominant in the early post-Cold War period, is no longer unquestioned.
Spatiotemporal Analysis of Extreme Precipitation in the Missouri River Basin from 1950 – 2019
Authors: Flanagan Paul , Mahmood Rezaul 
Published: April 2021

AbstractExtreme precipitation events are challenging to local and regional stakeholders across the United States. The Missouri River Basin (MoRB), covering an area over 1.29 million km2, is prone to extreme precipitation events. These events are exacerbated by the complex terrain in the west and the numerous weather and climate features which impact the region on a seasonal/annual basis (low-level jets, mesoscale convective systems, extreme cold air intrusions, etc.). Without an in-depth analysis of extreme precipitation in the MoRB, the evolving nature of extreme precipitation is not known. This warrants an analysis of extreme precipitation, especially relating to sub-annual variations when extreme precipitation is more impactful. To this end, data from 131 United States Historical Climatology Network (USHCN) stations were used to determine the nature of extreme precipitation from 1950 – 2019. Annual 99th percentile and annual station maximum precipitation events occur more frequently in the eastern MoRB than in the western MoRB, in line with the annual precipitation climatology. Results show that 99th percentile events and annual station maximum precipitation events are becoming more frequent across the MoRB. Through analysis of 3-month extreme precipitation trends, areas in the eastern and southern MoRB are shown to have an increasing event frequency and intensity. Frequency shifts in the 99th percentile events, however, have occurred across the entire region. The increasing frequency of extreme events in the western MoRB represent a significant change for the hydroclimate of the region. Overall, the results from this work show that MORB extreme precipitation has increased in frequency and intensity during the 1950 – 2019 period.
Extreme Surface Winds During Landfalling Atmospheric Rivers: The Modulating Role of Near-Surface Stability
Authors: Pagano Terence J. , Waliser Duane E. , Guan Bin , Ye Hengchun , Ralph F. Martin , Kim Jinwon 
Published: April 2021

AbstractAtmospheric rivers (ARs) are long and narrow regions of strong horizontal water vapor transport. Upon landfall, ARs are typically associated with heavy precipitation and strong surface winds. A quantitative understanding of the atmospheric conditions that favor extreme surface winds during ARs has implications for anticipating and managing various impacts associated with these potentially hazardous events. Here, a global AR database (1999–2014) with relevant information from MERRA-2 reanalysis, QuikSCAT and AIRS satellite observations are used to better understand and quantify the role of near-surface static stability in modulating surface winds during landfalling ARs. The temperature difference between the surface and 1 km MSL (ΔT; used here as a proxy for near-surface static stability), and integrated water vapor transport (IVT) are analyzed to quantify their relationships to surface winds using bivariate linear regression. In four regions where AR landfalls are common, the MERRA-2-based results indicate that IVT accounts for 22-38% of the variance in surface wind speed. Combining ΔT with IVT increases the explained variance to 36-52%. Substitution of QuikSCAT surface winds and AIRS ΔT in place of the MERRA-2 data largely preserves this relationship (e.g., 44% compared to 52% explained variance for USA West Coast). Use of an alternate static stability measure–the bulk Richardson number–yields a similar explained variance (47%). Lastly, AR cases within the top and bottom 25% of near-surface static stability indicate that extreme surface winds (gale or higher) are more likely to occur in unstable conditions (5.3%/14.7% during weak/strong IVT) than in stable conditions (0.58%/6.15%).
Parental health literacy and nutrition literacy affect child feeding practices: A cross-sectional study
Authors: Costarelli Vassiliki , Michou Maria , Panagiotakos Demosthenes B. , Lionis Christos 
Published: April 2021

Background: Health literacy (HL) and nutrition literacy (NL) are important issues to consider, in the provision of health care to children and the establishment of healthy eating behaviors. Aim: The study investigates the possible role of HL and NL levels of Greek parents, in parental Feeding Practices (PFP). Methods: This is a cross-sectional study which was conducted in the urban area of the Attica region, Greece. The sample consisted of 402 parents (68.4% mothers). Parents completed the Greek version of Comprehensive Parental Feeding Questionnaire, the European Health Literacy Questionnaire 47 and the Greek version of the Nutrition Literacy Scale. Sociodemographic and anthropometric characteristics were also assessed. The non-parametric tests Mann-Whitney and Kruskal Wallis, the chi-square test and linear regression models were applied. Results: The median for HL and NL were 33.69 and 24.00, respectively. Mothers applied the “child control” practice more frequently than fathers ( p = 0.015). Linear regression analysis revealed that HL was associated positively with “healthy eating guidance” and “monitoring” ( p = 0.009 and p < 0.0001, respectively) and negatively with “emotion regulation/food as reward” and “child control” ( p = 0.037 and p = 0.015, respectively). NL was associated positively only with “healthy eating guidance” ( p = 0.009), positively but marginally with “monitoring” ( p = 0.051) and negatively with “emotion regulation/food as reward” ( p = 0.020). Conclusions: Higher parental levels of HL and NL are significantly positively associated with better parental feeding practices in Greece.
Governing information technology (IT) investment: A contingency perspective on organization’s IT investment goals
Authors: Ali Syaiful , Green Peter , Robb Alastair , Masli Adi 
Published: April 2021

Using contingency theory, we argue that there is not a uniform approach for companies to govern information technology (IT) investments. Rather, the level of governance over IT investments is contingent upon the organization’s goals for its IT investments. We find that Australian organizations with both operation- and market-focused IT investment goals (i.e. dual-focused IT goals) demonstrate higher IT investment governance (ITIG) levels than those with less focused IT goals. We also document that dual-IT-focused firms that do not implement high levels of ITIG underperform. Our study informs business executives, boards of directors, and other practitioners interested in governance implementations over IT investments. JEL Classification: M1
Age Is More Predictive of Safe Movement Patterns Than Are Physical Activity or Sports Specialization: A Prospective Motion Analysis Study of Young Athletes
Authors: Heath Madison R. , Janosky Joseph J. , Pegno Angelo , Schachne Jonathan M. , Fabricant Peter D. 
Published: April 2021

Background: Movement quality and neuromuscular balance are noted predictors of acute injury. Early sports specialization and extremely high activity levels have been linked to elevated risk of injury. Purpose: To investigate for any relationships among quality of physical movement, quantity of physical activity, and degree of sports specialization in a healthy cohort of active children and adolescents. Study Design: Cross-sectional study with prospectively collected data. Methods: Healthy children between the ages of 10 and 18 years were recruited and completed the Hospital for Special Surgery Pediatric Functional Activity Brief Scale to assess quantity of physical activity and the Jayanthi scale to assess degree of sports specialization (high, score of 2 or 3; low, score of 0 or 1). Movement quality was assessed using motion analysis sensors during 5 repetitions of 4 different jumping and squatting motions, with a maximum score of 100 per participant. Independent-samples t tests were used to compare participants with high versus low specialization on physical activity and movement quality. A Spearman correlation was used to determine the relationship between quantity of physical activity and movement quality, and linear regression was used to assess for the effect of participant age on relevant covariables. Results: Final analyses included 147 participants (72% male) with a mean ± SD age of 13.4 ± 2.2 years. Participants who were highly specialized displayed better movement quality than did participants with low sports specialization (27.6 ± 14.0 vs 19.8 ± 10.1; P < .01). Participants who were highly specialized had significantly higher activity levels (24.6 ± 5.9 vs 18.1 ± 6.9; P < .001). Movement quality was moderately correlated with physical activity level ( r = 0.335; P < .001). Physical activity; hours of organized sports activity; hours of free, unorganized physical activity; and specialization level were not significant predictors of movement quality when controlling for age. Age alone predicted 24.2% of the variance in the overall movement quality score ( R2 = 0.242; B = 3.0; P < .001). Conclusion: This study found that sports specialization and physical activity levels were not associated with movement quality when controlling for age, which was the most important variable predicting athletic movement quality. Although all participants displayed movement patterns that were associated with high risk for injury, overall movement quality improved with advancing chronological age. Clinical Relevance: All young athletes should ensure that neuromuscular training accompanies sport-specific training to reduce risk of injury.
Hearing Loss Diagnosis and Early Hearing-Related Interventions in Infants With or at High Risk for Cerebral Palsy: A Systematic Review
Authors: Richard Céline , Kjeldsen Caitlin , Findlen Ursula , Gehred Alison , Maitre Nathalie L. 
Published: April 2021

Aim: To synthesize published evidence regarding hearing impairment diagnosis and interventions in infants with or at high risk for cerebral palsy in the first year after birth. Method: Nine databases were searched for MeSH terms up to February 2020. Included studies were published in English, enrolled infants with or at high risk for cerebral palsy, and addressed hearing evaluation/rehabilitation within the first year after birth. Quality of evidence was evaluated using RTI Item Bank and QUADAS-2. Results: Eighteen articles met inclusion criteria. Quality of the evidence ranged from low to high, revealing variability in diagnostic assessment methodologies and adherence to diagnostic schedules. Concerns for bias included lack of recognition of cerebral palsy effects and etiologies on functional hearing assessment methods and results. Two interventions (hearing aid and cochlear implantation) were identified; however, reported use was inconsistent. Interpretation: Hearing screening in infants with or at high risk for cerebral palsy requires evaluation of the entire auditory pathway preferentially using comprehensive electrophysiological panels of assessments. For infants with perinatal neural insults, pediatric neurologists are uniquely positioned to recommend adherence to systematic surveillance and comprehensive audiology assessments, regardless of comorbidities and motor impairments.
The effect of Covid-19 on ethical sensitivity
Authors: Mert Selda , Sayilan Aylin Aydin , Karatoprak Ayfer Peker , Baydemir Canan 
Published: April 2021

Background: In the midst of the Covid-19 pandemic, healthcare workers increasingly encounter serious ethical issues that negatively affect their professionalism. Purpose: The study aims to examine the ethical sensitivity levels of physicians and nurses working in surgical units during the Covid-19 pandemic and the associating factors. Method: The sample of this cross-sectional online questionnaire–based study consists of 161 healthcare workers working at the surgical units in Turkish hospitals. The data were collected using the “Nurse Descriptive Information Form” developed by the researchers and the “Ethical Sensitivity Questionnaire.” Ethical considerations: Approval was granted by the ethics committee. Verbal and written consent was received from the healthcare workers. Results: Ethical sensitivity in the dimension of conflict was found to be higher in healthcare workers who had ethical issues during the Covid-19 pandemic, who were married, who were nurses, who worked more than 45 h, and who had a work experience of 7–10 years (p < 0.05). Healthcare workers with a family member diagnosed with Covid-19 had high ethical sensitivity in the dimension of conflict (p = 0.008), while those who reported being fully competent and ready (p = 0.038) about Covid-19 were found to have low ethical sensitivity. Besides, those who experienced inadequate supplies (p = 0.045), long working hours (p = 0.038), and problems in asepsis–sterilization (p = 0.046) during the Covid-19 pandemic were found to have low sensitivity in the holistic approach dimension. Conclusion: The study revealed that ethical issues during the Covid-19 pandemic, sociodemographic characteristics, knowledge-skills about Covid-19, and the problems encountered in the work environment during the pandemic affect the ethical sensitivity of healthcare workers in the dimensions of conflict and holistic approach. Therefore, it is recommended that governments and all healthcare workers, and stakeholders in the health system in our country and other countries take action to promote ethical sensitivity in response to the rapidly increasing epidemic by considering the factors that adversely affect ethical sensitivity.
India–Vietnam Defence and Security Cooperation
Authors: Solanki Viraj 
Published: April 2021

Defence and security cooperation between India and Vietnam is an increasingly important area of the India–Vietnam ‘comprehensive strategic partnership’. This wide-ranging cooperation includes government-to-government dialogues, bilateral agreements, defence lines of credit, prospective defence procurements, maritime cooperation and multilateral cooperation. Cooperation has been formalised and expanded through a series of bilateral defence and security agreements to provide a basis for enhancing relations, which have been further developed through regular government-to-government dialogues. The defence and security dialogues and agreements have provided a framework for practical cooperation between the two countries’ militaries, which includes a focus on defence training, military exercises and discussions for the sale of different Indian arms equipment to Vietnam. Maritime cooperation between India and Vietnam has been the most significant element of bilateral defence and security cooperation, and both sides have found mutual convergences on cooperation in the South China Sea and the wider Indo-Pacific region. Relations between the two countries have also strengthened multilaterally on defence and security issues, including through the Association of Southeast Asian Nations. There are opportunities to further strengthen the India–Vietnam defence and security relationship, both bilaterally and with third countries.
Grief in Medical Students: The Short and Long-Term Impacts on Health and Well-Being
Authors: Price Meghan J. , Wachsmuth Lucas P. , Ferguson Kortni A. , Robbins-Welty Gregg A. , Riordan Paul A. , Pieper Carl F. , Galanos Anthony 
Published: April 2021

Context: Healthcare workers often experience grief stemming from the loss of patients under their care. The impact of personal grief on healthcare workers’ wellbeing is less well described, particularly for trainees. To better characterize the prevalence and impact of personal grief on the mental and physical health of medical students, we conducted a survey of medical students at our institution. Methods: An electronic Qualtrics survey was distributed to all currently enrolled medical students at our institution. After an initial question screening for loss before or during medical school, our survey assessed (1) basic demographic data; (2) relationship to the deceased; (3) impact of the loss on trainee health; and (4) utilization of institutional supports for grief. Results: A total of 344 (68.8%) students responded to our survey. Two hundred and 25 (65.4%) students had experienced personal loss prior to or during medical school. 53.7% experienced more than 1 loss, with most of these losses (62.5%) occurring more than 2 years prior to the survey date. Up to 40% of respondents reported at least 1 psychologically distressing symptom that persisted beyond 1 year. Most students (93.8%) relied on family members for support; however, 23.2% of students indicated they would use institutional resources if available. Conclusion: Most medical students have experienced bereavement before or during medical school, which has had significant impact on their well-being. While medical students did not typically utilize institutionally based resources, many students expressed interest in such resources.
Dental Arch Relationship Outcomes Following 2-Stage Palatoplasty for Japanese Patients With Complete Unilateral Cleft Lip and Palate: A 3-Center Study
Authors: Kato Junya , Mikoya Tadashi , Ito Yumi , Sato Yoshiaki , Uematsu Setsuko , Kodama Yasumitsu , Susami Takafumi , Yamanishi Tadashi , Takagi Ritsuo 
Published: April 2021

Objective: To compare dental arch relationship outcomes following 3 different 2-stage palatal repair protocols. Design: Retrospective, cross sectional. Setting: Three cleft palate centers (A, B, C) in Japan. Patients: Ninety (A: 39, B: 26, C: 25) consecutively treated Japanese patients with complete unilateral cleft lip and palate. Interventions: In A, the soft palate and the posterior half of the hard palate were repaired at a mean age of 1 year 7 months. In B, the soft palate and hard palate were closed separately at a mean age of 1 year 6 months and 5 years 8 months, respectively. In C, the soft palate and hard palate were closed at a mean age of 1 year and 1 year 5 months, respectively. Main Outcome Measures: Dental arch relationships were assessed using the 5-Year-Olds’ (5-Y) index by 5 raters and the Huddart/Bodenham (HB) index by 2 raters. Results: Intra- and inter-rater reliabilities showed substantial or almost perfect agreement for the 5-Y and HB ratings. No significant differences in mean values and distributions of 5-Y scores were found among the 3 centers. The mean HB index scores of molars on the minor segment were significantly smaller in C than those in A and B ( P < .05). Conclusions: There were no significant differences in dental arch relationships at 5 years among the times and techniques of hard palate closure. However, further analysis of the possible influence of infant cleft size as a covariable on a larger sample size is needed.