bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying the shape of cells - from Minkowski tensors to p-atic order
Authors: Happel Lea , Oberschelp Griseldis , Grudtsyna Valeriia , Jain Harish P. , Sknepnek Rastko , Doostmohammadi Amin , Voigt Axel 
Published: January 2025

AbstractP-atic liquid crystal theories offer new perspectives on how cells self-organize and respond to mechanical cues. Understanding and quantifying the underlying orientational orders is therefore essential for unraveling the physical mechanisms that govern tissue dynamics. Due to the deformability of cells this requires quantifying their shape. We introduce rigorous mathematical tools and a reliable framework for such shape analysis. Applying this to segmented cells in MDCK monolayers and computational approaches for active vertex models and multiphase field models challenges previous findings and opens new pathways for understanding the role of orientational symmetries andp-atic liquid crystal theories in tissue mechanics and development.
Elucidating the molecular landscape of centronuclear myopathies in mouse models: an integrative multi-omics and network analysis
Authors: Simon Alix , Gineste Charlotte , Reiss David , Thompson Julie , Laporte Jocelyn 
Published: January 2025

AbstractCentronuclear myopathies (CNM) are rare inherited muscle disorders characterized by muscle atrophy, weakness, and altered muscle fiber structure, primarily due to mutations in genes like MTM1, DNM2, and BIN1. The pathomechanisms implicated in CNM are only partially understood, and no curative therapies are available for patients. This study exploits a unique multi-omics dataset and network-based analyses to elucidate the molecular pathways involved in CNM. First, we performed Weighted Gene Co-expression Network Analysis (WGCNA) to identify gene modules correlated with CNM phenotypes. We find that modules correlated to a positive muscular phenotype were enriched for genes involved in muscle contraction, RNA processes and oxidative phosphorylation, while modules associated with impaired muscle structure and function were enriched in immune response, innervation, vascularization processes, and fatty acid oxidation. Next, we integrated transcriptomic, proteomic, and metabolomic data from theMtm1-/ymouse model with public knowledge bases using a multilayer network approach and explored the network using a random walk with restart approach. This study revealed novel metabolites that could be targeted through dietary supplementation as potential therapeutic strategies. Our findings demonstrate how multi-omics network analyses can reveal new aspects of CNM pathomechanisms and identify avenues for intervention.
Crystal structure of MutYX: A novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-Oxoguanine recognition sphere
Authors: Trasviña-Arenas C.H. , Hashemian Mohammad , Malek Melody , Merrill Steven , Fisher Andrew J. , David Sheila S. 
Published: January 2025

AbstractThe [4Fe-4S] cluster is an important cofactor of the base excision repair (BER) adenine DNA glycosylase MutY to prevent mutations associated with 8-oxoguanine (OG). Several MutYs lacking the [4Fe-4S] cofactor have been identified. Phylogenetic analysis shows that clusterless MutYs are distributed in two clades suggesting cofactor loss in two independent evolutionary events. Herein, we determined the first crystal structure of a clusterless MutY complexed with DNA. On the basis of the dramatic structural divergence from canonical MutYs, we refer to this as representative of a clusterless MutY subgroup “MutYX”. Interestingly, MutYX compensates for the missing [4Fe-4S] cofactor to maintain positioning of catalytic residues by expanding a pre-existing α-helix and acquisition of the new α-helix. Surprisingly, MutYX also acquired a new C-terminal domain that uniquely recognizes OG using residue Gln201 and Arg209. Adenine glycosylase assays and binding affinity measurements indicate that Arg209 is the primary residue responsible to specificity for OG:A lesions, while Gln201 bridges OG and Arg209. Surprisingly, replacement of Arg209 and Gln201 with Ala increases activity toward G:A mismatches. The MutYX structure serves as an example of devolution, capturing structural features required to retain function in the absence of a metal cofactor considered indispensable.
Zymoseptoria triticishow local differences in within-field diversity and effector variation
Authors: Herreno Andrea Tobian , Huang Pu , Siepe Isabella , Stam Remco 
Published: January 2025

AbstractZymoseptoria triticiis a cosmopolitan hemibiotrophic wheat pathogen with a high mutation rate and a mixed reproduction system, leading to challenges in traditional farming management. For successful integration of pest management, especially for early diagnostics of new aggressive or fungicide-resistant lineages, it is critical to understand population diversity in the field. We look at whole-genome sequence data for three datasets to differentiate within field diversity in fields of similar size: one dataset from a newly sampled field population from the United Kingdom and two publicly available datasets from fields from the United States and Switzerland.Inspection of population structure and diversity features, such as minor allele frequency distribution and clonality, show no within-field structure, the most abundant SNPs are present in low frequency, and European fields have higher clonality. Knowing that effectors play particularly important roles in (a)virulence, we specifically assess effector diversity characteristics. Whereas on a whole-genome scale, we can see separation of the populations at the regional scale, we do not find such separation for the effectors. Moreover, we find that multiple effector haplotypes can be found interspersed within the field and even occur within what has been considered clonal isolates or isolates from a single lesion.Our analyses highlight that within-fieldZ. triticidiversity is higher than previously reported. Our finding that multiple effector haplotypes can be found within a single lesion might explain the large resistance gene-breaking potential ofZ. tritici.
Visual field specializations in mouse dLGN
Authors: Cha Kuwook , Rangel Olguin Aline Giselle , Sharif-Naini Reza , Cook Erik P. , Krishnaswamy Arjun 
Published: January 2025

AbstractNeural circuits throughout the visual system process features differently depending on where they appear in the visual field. While such location-specific processing exists in retina and in superior colliculus, the dorsal lateral geniculate nucleus (dLGN) is thought to lack this specialization. Here, we show systematic visual field biases in dLGN’s representation of spatial frequency, orientation, direction, and temporal frequency. Using axon-localized calcium indicators and widefield imaging, we discovered that dLGN boutons show systematic gradients in feature selectivity across the visual cortex (V1), while its retinal inputs lack such gradients for these features. Selective disruption of V1 feedback to dLGN perturbed gradient structure and magnitude. These results suggest that dLGN circuits transform uniformly distributed retinal feature inputs into spatially-biased representations along with cortical feedback. dLGN feature biases would allow a functional stream to detect ethologically salient visual inputs.
The role of personal values in the relationship between job demands and well-being among entrepreneurs
Authors: Bui Huy Nhuong , Le Mai Thi Thu , Nguyen Ngoc Lan , Cox Susie , Pham Thuy Thi Thanh , Bui Mai Thi Thanh 
Published: January 2025

Purpose
This study aims to investigate whether personal values can moderate the relationship between entrepreneurs’ job demands and their well-being.

Design/methodology/approach
The data from an email survey involving 307 entrepreneurs in the two largest cities in Vietnam were analysed.

Findings
The analysis results indicated that the values of self-transcendence, openness to change and self-enhancement, which were identified as personal resources in this study, can help entrepreneurs maintain positive well-being even when they face challenging job demands in their business ventures. In contrast, conservation values reinforce the negative influence of job demands on their well-being.

Practical implications
Practically, entrepreneurs are encouraged to develop certain personal values, and policymakers should endorse these values through policy proposals and amendments that facilitate entrepreneurship through education and reduced bureaucracy.

Originality/value
This study further extends Conservation of Resources theory based on the mechanism that entrepreneurs use their personal values as resources to mitigate the negative impacts of the job demands of entrepreneurship on their well-being.
Exploring weight inclusive vs. weight-normative approaches in high school nutrition education
Authors: Hinchey Deb , Garnett Bernice , Gamble Janet , Pope Lizzy 
Published: January 2025

PurposeTeaching about nutrition is a crucial component of high school health education, with the potential to shape students' perceptions about food, weight and bodies and improve health outcomes. Weight-inclusive approaches have demonstrated success in improving body acceptance, decreasing dieting behaviors and anti-fat attitudes and improving health outcomes and may decrease weight-based bullying. However, little is known about nutrition education in high school settings. This study sought to understand how high school health teachers in Vermont are teaching about the connections between nutrition, weight and bodies and what influences their nutrition-focused curricular decisions. The goal is to inform the development of a novel weight-inclusive curriculum for high school health teachers in Vermont and beyond.Design/methodology/approachThis study used case study methodology: qualitative interviews with eight teachers and document analysis of curricular materials.FindingsFindings indicate that weight-normative activities and values dominate curriculum and that multiple levels exert influence on teacher curricular decisions. Findings confirm a need for the development and implementation of a weight-inclusive nutrition curriculum, professional development for health teachers and policy-level interventions as strategies to improve health outcomes.Research limitations/implicationsLimitations of the data collection include a small within-case sample size and limited availability of documents to review. However, the triangulation of gathered and publicly available data ultimately supported an in-depth case study.Originality/valueThe findings from this study inform future directions for both curriculum and professional development for high school health teachers, which is essential for improving health outcomes, reducing stigma and moving toward justice. This is original work.
Stock market development and foreign direct investment: the moderating role of government effectiveness
Authors: Mapendo Joseph James , Senadjki Abdelhak , Choong Yuen Onn 
Published: January 2025

PurposeThis study examines the influence of the stock market on foreign direct investment in developing countries and how government effectiveness moderates this relationship.Design/methodology/approachThe study involved four East African Community countries and a panel dataset from 1995 to 2020. The study utilized feasible generalized least squares (FGLS) as a primary model and panel-corrected standard errors (PCSE) for a robustness check.FindingsThe impact of the stock market on foreign direct investment (FDI) is mixed. While value traded, market capitalization and the number of listed companies positively affect FDI, stock turnover has a negative impact. Government effectiveness also positively influences FDI and significantly moderates the relationship with the stock market.Research limitations/implicationsThe sample is only limited to stock markets and East African Community countries, and due to the unavailability of data, only four countries were captured.Practical implicationsStock markets and government effectiveness are crucial for attracting FDI by enhancing the attractiveness of host countries for investment. The policymakers should improve institutional quality, support stock market development, bolster investment appeal and provide an alternative capital source.Social implicationsPolicy formulation should encourage institutional quality practices and support the stock market development that serves as an alternative source of capital.Originality/valueThis paper examines how stock markets impact FDI inflows and investigates the moderating role of government effectiveness in this relationship. The findings reveal that both stock market development and government effectiveness enhance a host country’s attractiveness for inward FDI.
The growth of social innovation research in higher education institutions (HEIs)
Authors: Bui L.A. Phuong , Le Hang Nguyen Tue , Hazenberg Richard 
Published: January 2025

Purpose
The purpose of this study is to explore the development of “social innovation (SI)” research within Higher Education Institutions (HEIs) context.

Design/methodology/approach
This paper explores academic databases (Web of Science/Scopus/Sage), to identify relevant papers focused on SI. Using a systematic literature review (SLR) with narrative-assessment approach, the “VOSviewer” tool is used to analyse relationships between themes/subthemes related to SI in HEIs. Additionally, Excel’s polynomial-trendline feature is used to track publication numbers over time.

Findings
This research identified five themes related to HEIs and SI trends, each exposing important aspects of higher education and SI, including “Sustainable Development; Social Entrepreneurship; Digital Transformation; Research; and Innovation Culture.” This research also identifies best practices of global universities and their SI programmes across 19 topics, including changes in publication volume since 1996.

Practical implications
The SLR reveals research gaps related to HEIs and SI trends that require further investigation. Each of these areas gives scholars/practitioners opportunities for in-depth investigation.

Social implications
The findings of this study encourage global HEIs to implement SI, become acquainted with the present themes and the programmes conducted by HEIs, recognise the importance of SI trends and fill HE provision gaps around SI.

Originality/value
This paper contributes to knowledge on the promotion of SI in HEIs and sustainable development, while identifying gaps for further research.
Assessing changes in thinking about troubleshooting in physical computing: a clinical interview protocol with failure artifacts scenarios
Authors: Morales-Navarro Luis , Fields Deborah , Kafai Yasmin B. , Barapatre Deepali 
Published: January 2025

Purpose
The purpose of this paper is to examine how a clinical interview protocol with failure artifact scenarios can capture changes in high school students’ explanations of troubleshooting processes in physical computing activities. The authors focus on physical computing, as finding and fixing hardware and software bugs is a highly contextual practice that involves multiple interconnected domains and skills.

Design/methodology/approach
This paper developed and piloted a “failure artifact scenarios” clinical interview protocol. Youth were presented with buggy physical computing projects over video calls and asked for suggestions on how to fix them without having access to the actual project or its code. Authors applied this clinical interview protocol before and after an eight-week-long physical computing (more specifically, electronic textiles) unit. They analyzed matching pre- and post-interviews from 18 students at four different schools.

Findings
The findings demonstrate how the protocol can capture change in students’ thinking about troubleshooting by eliciting students’ explanations of specificity of domain knowledge of problems, multimodality of physical computing, iterative testing of failure artifact scenarios and concreteness of troubleshooting and problem-solving processes.

Originality/value
Beyond tests and surveys used to assess debugging, which traditionally focus on correctness or student beliefs, the “failure artifact scenarios” clinical interview protocol reveals student troubleshooting-related thinking processes when encountering buggy projects. As an assessment tool, it may be useful to evaluate the change and development of students’ abilities over time.
Exploring the influence of core self-evaluation on students’ academic self-efficacy: a qualitative study considering anxiety and interpersonal responses
Authors: Zeb Irum , Khan Aashiq , Yan Zhang 
Published: January 2025

PurposeThis study explores the influence of core self-evaluation (CSE) on students’ academic self-efficacy, anxiety and interpersonal responses. It investigates how internal beliefs impact academic success among Chinese higher education students.Design/methodology/approachA qualitative research design was employed, using semi-structured interviews with 30 students from various disciplines at H University. The thematic analysis was utilized to interpret the data.FindingsThe findings suggest that students with higher levels of CSE exhibit greater academic confidence and can manage academic-related stress and depression. Positive interpersonal responses enhanced academic self-efficacy, confidence and inner motivation, serving as a buffer against the negative effects of anxiety. Moreover, students’ perceptions of their emotional stability and control contributed significantly to their academic confidence and resilience.Research limitations/implicationsThe study is limited by its qualitative nature and the sample size, which is restricted to one university. These limitations may affect the generalizability of the findings. Future research could employ a mixed-methods approach to corroborate these findings across different cultural settings and educational systems.Practical implicationsThe study highlights the importance of a supportive educational environment that fosters positive self-evaluations and interpersonal responses to enhance students' academic self-efficacy. Educational institutions should consider integrating psychological support mechanisms and opportunities for developing interpersonal skills within their curricula.Originality/valueThis research contributes to the limited literature on the impact of core self-evaluation in Chinese higher education, particularly highlighting the complex relationship between personal beliefs, emotional management and social interactions in shaping academic outcomes.
Exploring renting models for clothing items – resource interaction for value creation
Authors: Andersson Wänström Agnes , Hjelmgren Daniel , Landqvist Maria , Lind Frida 
Published: January 2025

Purpose
The purpose of this paper is to explore renting models for clothing items and their value creation logics with a basis in resource interaction.

Design/methodology/approach
The paper relies on a multiple case study of renting models pursued by start-up companies in the Swedish context. The cases cover fashion wear as well as outdoor clothing. The theoretical frame builds on the industrial marketing and purchasing approach to business markets with a special focus on resource interaction and value creation.

Findings
The multiple case study provides the basis for identifying three categories of renting models: membership, subscription and individual item renting. The three models use different patterns of resource mobilisation, resource utilisation and resource combination to build their value creation logics.

Research limitations/implications
A plethora of different business models for sharing resources will be needed in reaching sustainable development in the fashion context. Renting models is one such model for sharing resources that increase product usage but struggles with economic sustainability.

Practical implications
The paper offers implications for actors in the fashion industry and capital systems by considering renting models not as tech start-ups but as sustainable start-up business models in which investments require longer time frames before showing results.

Originality/value
Few studies have treated the variety of renting models for clothing items. Thereby this paper extends the literature by providing a categorization of such models and how they create value.
Influence of oil price fluctuations on inflation uncertainty
Authors: Aladwani Jassim 
Published: January 2025

Purpose
The purpose of this study is to achieve a comprehensive understanding of how the intricate interconnections between oil price fluctuations, supply chain disruptions and shifting demand patterns collectively shape inflation dynamics within the Chinese economy, especially during critical periods such as the Covid-19 pandemic and geopolitical events like the Russia–Ukraine conflict. The importance of assessing the impact of oil price volatility on China’s inflation becomes particularly pronounced amidst these challenging circumstances.

Design/methodology/approach
This study uses the Markov Regime-Switching generalized autoregressive conditional heteroskedasticity (MRS-GARCH) family of models under student’s t-distributions to measure the uncertainty of oil prices and the inflation rate during the period spanning from 1994 to 2023 in China.

Findings
The results indicate that the MRS-GJR-GARCH-in-mean (MRS-GARCH-M) models, when used under student’s t-distributions, exhibit superior performance in modeling the volatility of both oil prices and the inflation rate. This finding underscores the effectiveness of these models in capturing the intricacies of volatility dynamics in the context of oil prices and inflation. The study has identified compelling evidence of regime-switching behavior within the oil price market. Subsequently, the author conducted an analysis by extracting the forecastable component, which represents the expected variation, from the best-fitted models. This allowed us to isolate the time series of oil price uncertainty, representing the unforecastable component. With this unforecastable component in hand, the author proceeded to estimate the impact of oil price fluctuations on the inflation rate. To accomplish this, the author used an autoregressive distributed lag model, which enables us to explore the dynamic relationships and lags between these crucial economic variables. The study further reveals that fluctuations in oil prices exert a noteworthy and discernible influence on the inflation rate, with distinct patterns observed across different economic regimes. The findings indicate a consistent positive impact of oil prices on inflation rate uncertainty, particularly within export-oriented and import-oriented industries, under both of these economic regimes.

Originality/value
This study offers original value by analyzing the impact of crude oil price volatility on inflation in China. It provides unique insights into the relationship between energy market fluctuations and macroeconomic stability in one of the world’s largest economies. By focusing on crude oil – a critical but often overlooked component – this research enhances understanding of how energy price dynamics influence inflationary trends. The findings can inform policymakers and stakeholders about the significance of energy market stability for maintaining economic stability and guiding inflation control measures in China.