bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault Diagnosis of Rolling Bearing based on an Improved Denoising Technique using Complete Ensemble Empirical Mode Decomposition and Adaptive Thresholding Method
Authors: Sahu Prashant Kumar , Rai Rajiv Nandan 
Published: February 2021

Abstract
The vibration signals for rotating machines are generally polluted by excessive noise and can lose the fault information at the early development phase. In this paper, an improved denoising technique is proposed for early faults diagnosis of rolling bearing based on the complete ensemble empirical mode decomposition (CEEMD) and adaptive thresholding (ATD) method. Firstly, the bearing vibration signals are decomposed into a set of various intrinsic mode functions (IMFs) using CEEMD algorithm. The IMFs grouping and selection are formed based upon the correlation coefficient value. The noise-predominant IMFs are subjected to adaptive thresholding for denoising and then added to the low-frequency IMFs for signal reconstruction. The effectiveness of the proposed method denoised signals are measured based on kurtosis value and the envelope spectrum analysis. The presented method results on experimental datasets illustrate that the proposed approach is an effective denoising technique for early fault detection in the rolling bearing.
Plant Biomass and Soil Nutrients Mainly Explain the Variation of Soil Microbial Communities during Secondary Succession on the Loess Plateau
Authors: Xu Miao-Ping , Wang Jia-Yi , Han Xin-Hui , Ren Cheng-Jie , Yang Gai-He 
Published: February 2021

Abstract
Soil microorganisms play an important role in the circulation of materials and nutrients between plants and soil ecosystems, but the drivers of microbial community composition and diversity remain uncertain in different vegetation restoration patterns. We studied soil physicochemical properties (i.e., soil moisture, bulk density, pH, soil nutrients, available nutrients), plant characteristics (i.e., Shannon index [HPlant] and Richness index [SPlant], litter biomass [LB], and fine root biomass [FRB]), and microbial variables (biomass, enzyme activity, diversity and composition of bacterial and fungal communities) in different plant succession patterns (Robinia pseudoacacia [MF], Caragana korshinskii [SF] and grassland [GL]) on the Loess Plateau. The herb communities, soil microbial biomass and enzyme activities were strongly affected by vegetation restoration. And soil bacterial and fungal communities were significantly different from each other at the sites. Furthermore, LB and FRB were significantly positively correlated with SBacteria, soil microbial biomass, enzyme activities, Proteobacteria, Zygomycota and Cercozoa, while negatively correlated with Actinobacteria and Basidiomycota. In addition, soil water content (SW), pH and nutrients have important effects on the bacterial and fungal diversities, Acidobacteria, Proteobacteria, Nitrospirae, Zygomycota and microbial biomass. Furthermore, plant characteristics and soil properties modulated the composition and diversity of soil microorganisms, respectively. Overall, the relative contribution of vegetation and soil to the diversity and composition of soil bacterial and fungal communities illustrated that plant characteristics and soil properties may synergistically modulate soil microbial communities. And soil bacterial and fungal communities mainly depend on plant biomass and soil nutrients.
Effectiveness of Naloxegol in Patients With Cancer Pain Suffering From Opioid-Induced Constipation
Authors: Lemaire Antoine , Pointreau Yoann , Narciso Bérengère , Piloquet François-Xavier , Braniste Viorica , Sabaté Jean-Marc 
Published: February 2021

Abstract
Purpose

Naloxegol, an oral once-daily peripherally acting mu-opioid receptor antagonist, is indicated for the treatment of opioid-induced constipation (OIC) with inadequate response to laxative(s), in cancer and non-cancer patients. This study mainly aimed to assess in real-life conditions the efficacy and safety of naloxegol in cancer pain patients, and the evolution of their quality of life.
Methods

A non-interventional, 4-week follow-up study was conducted in 24 French oncology and pain centers between 2018 and 2019. Eligible patients were aged ≥ 18 years, treated with opioids for cancer-pain, and started naloxegol for OIC with inadequate response to laxatives. The rate of the response to naloxegol (primary criterion) was assessed at W4. The evolution of quality of life was measured using the Patient Assessment of Constipation Quality of Life (PAC-QOL).
Results

A total of 124 patients were included (mean age: 62 ± 12 years; ECOG ≤ 2: 79%; primary cancer: lung 18%, breast 16%, prostate 11%, head and neck 9%, digestive 9%...; metastatic stage: 80%). At inclusion, the median opioid dosage was 60 mg of oral-morphine or equivalent. At W4, the response rate was 73.4% (95% CI [63.7%-83.2%]) and 62.9% (95% CI [51.5%-74.2%]) of patients had a clinically relevant change in quality of life (decrease in PAC-QOL score ≥ 0.5 point). Adverse events related to naloxegol were reported in 8% of patients (7% with gastrointestinal events; one serious diarrhea).
Conclusion

This real-world study shows that naloxegol is effective and well tolerated in cancer pain patients with OIC and that their quality of life improves under treatment.
Multifunctional Molecule, JM-20, Reverses Aluminum Chloride-Induced Memory Impairment and Neuronal Damage in Rats
Authors: Wong-Guerra Maylin , Montano-Peguero Yanay , Ramírez-Sánchez Jeney , Jiménez-Martin Javier , Fonseca-Fonseca Luis Arturo , Hernández-Enseñat Daniela , Nonose Yasmine , Valdés Odalys , Mondelo-Rodriguez Abel , Ortiz-Miranda Yaquelin , Bergado Gretchen , Carmenate Tania , Valle Roberto Menéndez Soto del , Pardo-Andreu Gilberto , Outeiro Tiago Fleming , Padrón-Yaquis Alejandro Saúl , Assis Adriano Martimbianco de , Souza Diogo O , Nunez-Figueredo Yanier 
Published: February 2021

Abstract
Alzheimer's disease (AD) is a neurodegenerative disease that worsens with aging. Today, there is a worldwide effort to find new drugs that could delay the onset, slow the progression, or improve symptoms of AD. Oral administration of aluminum to rodents recapitulates some pathological alterations observed in AD, being considered a convenient tool for modeling and testing the efficacy of new therapeutics. Our previous studies have shown that JM-20, a dihydropyridine and benzodiazepine hybrid molecule protected memory in an environment with cholinergic dysfunction, high oxidative stress, hyperactivation of acetylcholinesterase (AChE) enzyme, and mitochondrial damage produced by scopolamine. In order to gain further insight into the effects on JM-20 on AD pathology, we evaluated the protective effects of JM-20 after chronic AlCl3 administration to rats, and assessed several types of episodic memory alterations and associated-pathological mechanisms, including mitochondrial dysfunction, AChE hyperactivity, inflammation, and apoptosis-related proteins. We used behavioral tasks to test spatial, working an emotional- associative memory, as well as molecular, enzymatic and histological assays to evaluate selected biochemical parameters. Our study showed that JM-20 prevented memory decline alongside with the inhibition of aluminum-induced alterations of oxidative parameters, and increase of AChE activity and of tumor necrosis factor alpha (TNF-α) levels. JM-20 also preserved anti-apoptotic proteins and protected against axonal and neuronal damaged in the hippocampus and prefrontal cortex. Altogether, our findings expanded our understanding of the ability of JM-20 to preserve essential types of memory in rats under neurotoxic conditions, and suggest its potential capacity to counteract etiological factors of AD by breaking the progression of key neurodegeneration-associated steps in a rat model of the disease.
Impact of Green Entrepreneurship Orientation on Environmental Performance: The Natural Resource-Based View Perspective
Authors: Makhloufi Lahcene , Meirun Tang , Belaid Fateh , Yaacob Noorulsadiqin Azbiya 
Published: February 2021

Abstract
Environmental sustainability is the primary task of environmental entrepreneurship by critically handling increased institutional, customer, and environmental pressures. Green entrepreneurship orientation (GEO) seeks to harmonize their relationships with the external environment to foster the impact of green innovation performance (GIP) on environmental performance (EP). Drawing upon the natural resource-based view, the study examines the effect of green entrepreneurship orientation on GIP and EP. Additionally, the moderating effect of managerial environmental concerns (MEC) on this relationship is also inspected. The results revealed that green absorptive capacity (GAC), environmental cooperation (EC), and MEC significantly affect GEO. Furthermore, GEO positively influenced GIP and EP. Indeed, GEO partially mediates GAC, EC, and managerial concern’s relationship on green innovation and EP. Additionally, MEC significantly moderates the relationship between GEO and EP. Firms GEO should adequately enhance green practices performance and environmental performance to accommodate their external environment relationships. Theoretical and practical implications were also presented.
Preparation and Dielectric Properties of the Amorphous Basaltic Glass
Authors: Liu Changjiang , Tong Xiaocong , Yang Chuncheng , Jiang Letao , Li Yan , Zhang Lei , Ding Baoming , Liu Zhong , Huang Heyu , Li Hongchao 
Published: February 2021

Abstract
Due to the continuous basalt fiber is a kind of amorphous material, only the basaltic glass without crystallization can represent its dielectric properties. To explore the dielectric properties of the continuous basalt fiber, amorphous basaltic glass must be prepared. The present research focuses on the influence of chemical component on the preparation process of the amorphous basaltic glass and its dielectric properties. The basaltic rocks from different places of China were melted at 1500℃, then the melt was poured into the mould, at last glass sample was annealed at 650℃ for 2h. Ten groups of basaltic rocks were studied, and the results showed that the melt viscosity of basaltic rocks with 55-58% SiO2 was poor at 1500℃. The high-content of Fe2O3 and TiO2 in basaltic rocks was found to enhance the formation of magnetite (Fe3O4) crystal during the annealing process. The other five groups of basaltic rocks were suit to the amorphous basaltic glass. At 1MHz, the best dielectric constant of amorphous basaltic glass is 6.55, the dielectric loss is 4.034×10-3.
Adipose-Derived Stromal Vascular Fraction and Fat Grafts Versus Medical Treatment for Treating the Hands of Patients With Systemic Sclerosis. A Randomized Crontolled Trial
Authors: Iglesias Martin , Torre-Villalvazo Ivan , Butrón-Gandarillas Patricia , Rodríguez-Reyna Tatiana S , Torre-Anaya Erik A , Tovar-Palacio Armando R , Zentella-Dehesa Alejandro , Guevara-Cruz Martha , Hernandez-Campos Alan M 
Published: February 2021

Abstract
Background. In the hand, the Systemic Sclerosis (SS) is characteristically evidenced by Raynaud's phenomenon (RP) and fibrosis of the skin, tendons, ligaments, and joints as well as digital ulcers with prolonged healing. Current medical treatment not always cure these complications. Local adipose-derived stromal vascular fraction (ADSVF) administration into the hands has been proposed as an emerging treatment for these complications, due to its proangiogenic, antifibrotic, and immunoregulatory activities. The objective of this controlled trial was to evaluate the safety and clinical effects of fat micrografts plus ADSVF administration into the hands of patients with SS.Methods. This was an open-label, monocentric, randomized controlled study. Twenty patients diagnosed with SS were enrolled and assigned to the experimental or control group. Fat micrografts plus the ADSVF were injected into the right hand of experimental group patients. The control group continued to receive only medical treatment. Demographic, serologic data and disease severity were recorded. Digital oximetry, pain, Raynaud phenomenon (RP), digital ulcer healing (DUH), mobility, thumb opposition, vascular density of the nail bed, skin affection of the hand, Serologic antibodies, hand function, and quality of life scores were evaluated in both groups. The mean follow-up period was 168 days. The differences between before and after the intervention were analyzed with the Wilcoxon range test, and the differences between the control and experimental groups at 0 days and 168 days were analyzed with the Mann–Whitney U test.Results. Adverse events were not observed in both groups. There were no changes in disease severity, serologic antibodies, nailfold capillaroscopy patterns, mobility, and hand function in both groups. There were significant improvements in pain, DUH and quality of life scores in the experimental group. RP improved significantly in both groups. However, on statistically comparing the results at 168 days between the groups, significant improvements were only observed in pain levels (p = 0.02) and DUH (p=0.003).Conclusions. The injection of ADSVF plus fat micrografts is a reproducible, and safe technique. Pain and digital ulcers in the hands of patients with SS can be treated with this treatment. Trial Registration: Retrospectively registered in ClinicalTrials.gov with identifier NCT04387825
Sustainable Approaches Towards Aquaculture: Microalgal Circular Economy Perspectives
Authors: Mishra Bharti , Tiwari Archana , Mahmoud Alaa El Din 
Published: February 2021

Abstract
Microalgae have higher nutritional value as they are abundant in protein, carbohydrates, lipids, and vitamins. Hence, they play several important roles in aquaculture and are known as a major source of the food chain for aquaculture organisms. Furthermore, they are also used indirectly or directly by humans as food supplements and medicines to improve health by strengthening the immune system. Microalgae are used as biocontrol agents because they have biocidal properties, produce biomolecules (beta carotene, PUFA, and astaxanthin), wastewater, are a renewable resource of biofuel, and are used in wastewater treatment. Due to the overexploitation of wild fish and pollution, aquaculture faces serious issues. Eco- friendly methods are required to overcome this problem, so, microalgae are in practicing, that control the water pollution. Fishmeal is a rich source of protein in aquaculture but it is decreasing over time and has become cost-effective, so, to solve the problem, microalgae are used to replace the fishmeal which (microalgae as aquafeed) is cheap and not required large area to grow. Microalgae are seemed to be very useful in the growth enhancement of aquatic organisms.
Antenatal Care Visits of Child-Bearing Mothers Having a Child Five Years Preceding in the Survey and Associated Factors in Benchi-Sheko Zone, Southwestern Ethiopia: Cross-Sectional Study
Authors: Gelaw Assaye Belay , Andargie Solomon Abebaw , Terefe Abiyot Negsh 
Published: February 2021

Abstract
Background: Antenatal care (ANC) is the service given by the caregiver for pregnant women to make safe the health of both pregnant women and babies during the pregnancy period. The objective of the current study was to persuade high-quality public health service and plan the mothers and their households expressively and mentally for being motherhood by ever-increasing antenatal care visits from health institutions.Methods: Community-based cross-sectional study design was applied. Cross-sectional survey design mainly used for the collection of information on the Utilization of Antenatal Care Visit of Women During Pregnancy and its Related Factors in Bench-Sheko Zone, South Nation Nationalities Peoples of Region, Southwestern Ethiopia: Cross-sectional study. The study populations are all populations who are living in the study area, South Nation Nationalities peoples of Region, Southwestern Ethiopia.Results: Evidence tells us, one hundred twenty-nine (16.9%) of pregnant women were not visited by the caregiver during pregnancy. Around eighty-three percent of pregnant women were visited in health institutions at least once prior in the five years in the survey. The Poisson regression model was preferred to fit the data. As the output indicated in analysis, the odds ratio of women whose husband education status is illiterate is equal to exp(-0.272)=0.76(95% CI:-0.507,-0.038) (other variables are adjusted), it indicates that the women whose husband education status is 0.76 less likely to ANC visit than women whose husband education status is higher and above. Conclusions: The remark conclusion that the source of information, religion, educational status, birth order, knowledge of danger signs for pregnancy, and service satisfaction were significant at the alpha level of significance on the ANC visit of Women during pregnancy.
Lung Inflammation from Single and Repetitive Exposure to Glyphosate
Authors: Pandher Upkardeep Singh , Kirychuk Shelley , Schneberger David , Thompson Brooke , Aulakh Gurpreet , Sethi RS , Singh Baljit 
Published: February 2021

Abstract
Background: Glyphosate is an active ingredient in herbicides used in agriculture worldwide. Exposure to glyphosate has been associated with respiratory dysfunctions in agricultural workers. However, the ability of glyphosate to induce inflammation in the lung is not well studied. Therefore, we evaluated lung inflammatory response to glyphosate at agricultural relevant dose for single and repetitive exposures. Methods: Male C57BL/6 mice were intranasally exposed to glyphosate (1 μg/40 μl) for 1-day or once daily for 5-days, and 10-days. After the exposure periods, mice were euthanized to collect the bronchoalveolar lavage (BAL) fluid and lung tissue. Results: Repetitive exposure to glyphosate for 5-days and 10-days showed an increase of neutrophils in BAL fluid and eosinophil peroxidase levels in lungs, a marker for eosinophils. Leukocyte infiltration in lungs was further confirmed through lung histology. Th2 cytokines including IL-5 and IL-13 were increased in BAL fluid after 10-days of glyphosate exposure whereas IL-4 was not increased. Lung sections from all glyphosate groups showed higher expression for ICAM-1, VCAM-1, and vWF adhesion molecules. TLR-4 and TLR-2 expression was increased in lungs after repetitive exposure to glyphosate. Conclusions: We conclude that repetitive exposure to glyphosate induces migration of neutrophils and eosinophils and release of Th2 cytokines. This study, for the first time, provides evidence for the role of ICAM-1, VCAM-1 and vWF in lungs of glyphosate-treated animals.
Seasonal Variation and Sources of Carbonaceous Species and Elements in PM2.5 and PM10 Over the Eastern Himalaya
Authors: Sharma Sudhir Kumar , Mukherjee Sauryadeep , Choudhary Nikki , Rai Akansha , Ghosh Abhinandan , Chatterjee Abhijit , Vijayan Narayanswami , Mandal Tuhin Kumar 
Published: February 2021

Abstract
The study represents the seasonal characteristics (carbonaceous aerosols and elements) and contribution of prominent sources PM2.5 and PM10 in the high altitude of the eastern Himalaya (Darjeeling) during August 2018-July 2019. Carbonaceous aerosols [organic carbon (OC), elemental carbon (EC) and water soluble organic carbon (WSOC)] and elements (Al, Fe, Ti, Cu, Zn, Mn, Cr, Ni, Mo, Cl, P, S, K, Zr, Pb, Na, Mg, Ca, and B) in PM2.5 and PM10 were analyzed to estimate their possible sources. The annual average concentration of PM2.5 and PM10 were computed as 37±12 µg m-3 and 58±18 µg m-3, respectively. In the present case, total carbonaceous species in PM2.5 and PM10 were accounted for 20.6% of PM2.5 and 18.6% of PM10, respectively. Whereas, trace elements in PM2.5 and PM10 were estimated as 15% of PM2.5 and 12% of PM10, respectively. Monthly are seasonal variations in concentrations of carbonaceous aerosols and elements in PM2.5 and PM10 were also observed during the observational period. The positive relationship between OC & EC and OC & WSOC of PM2.5 and PM10 during all the seasons (except monsoon in case of PM10) indicate rheir common sources. The enrichment factors (EFs) and significant positive correlation of Al with othe crustal elements (Fe, Ca, Mg and Ti) of fine and coarse mode aerosols indicates the influence of mineral dust at the Darjeeling. Principal component analysis (PCA) resolved the four common sources (biomass burning + fossil fuel combustion (BB+FFC), crustal/soil dust, vehicular emissions (VE) and industrial emissions (IE)) of PM2.5 and PM10 in Darjeeling.
Lipid profile of bovine grade-1 blastocysts produced either in vivo or in vitro before and after slow freezing process
Authors: Idrissi Sarah Janati , Bourhis Daniel Le , Lefevre Antoine , Emond Patrick , Berre Laurene Le , Desnoës Olivier , Joly Thierry , Buff Samuel , Maillard Virginie , Schibler Laurent , Salvetti Pascal , Elis Sebastien 
Published: February 2021

Abstract
Currently, in vitro embryo production (IVP) is successfully commercially applied in cattle. However, the high sensitivity of embryos to cryopreservation in comparison to in vivo (IVD) embryos slows the dissemination of this biotechnology. Reduced cryotolerance is frequently associated with lipid accumulation in the cytoplasm mainly due to in vitro culture conditions. The objective of this study was to evaluate the lipid composition of biopsied and sexed embryos, produced either in vivo or in vitro from the same Holstein heifers before and after a slow freezing protocol. Lipid extracts were analysed by liquid chromatography-high resolution mass spectrometry, which enabled the detection of 496 features. Our results highlighted a lipid enrichment of IVP embryos in triglycerides and oxidised glycerophospholipids and a reduced abundance in glycerophospholipids. The slow freezing process affected the lipid profiles of IVP and IVD embryos similarly. Lysophosphatidylcholine content was reduced when embryos were frozen/thawed. In conclusion, the embryonic lipid profile is impacted by IVP and slow freezing protocols but not by sex. Lysophosphatidylcholine seemed highly sensitive to cryopreservation and might contribute to explain the lower quality of frozen embryos. Further studies are required to improve embryo freezability by modulating the lipidome.
A Field Trial of an Educational Intervention to Promote Safe Behaviors in Pedestrians: Study Protocol
Authors: Harofteh Fateme Zare , Hidarnia Alireza , Morowatisharifabad Mohammad Ali , Eslami Mohammad 
Published: February 2021

Abstract
Background: Pedestrians are vulnerable in traffic, and unsafe behaviors often lead to their injury. The aim of this study is to investigate the effect of a theory-based training package (TBTP) on improving pedestrians’ safe traffic behaviors.Methods: This study is a protocol for a field trial with parallel arms to examine the effect of educational intervention on 204 pedestrians that are selected using multi-stage cluster sampling. In order to prepare a training package, a sequential exploratory mixed study will be performed in 4 phases: 1) A questionnaire will be designed using a qualitative study and constructs of the theory of planned behavior (TPB). 2) A cross-sectional study will be performed to evaluate the psychometrics of the questionnaire and current situation, 3) The training package will be designed based on the previous phase findings, results of related studies, opinions of a panel of experts and effective techniques for behavior and belief change. 4) The effect of training will be measured using pre and posttest to comparing the mean scores of different theory constructs on pedestrians’ behavior between the intervention and control groups before and three months after the intervention. The between-group differences in terms of demographic variables, awareness, risk perception, beliefs, intention and behavior will be examined first. Paired t-test and ANCOVA will be applied to evaluate the effect of the intervention between the two groups.Discussion: The present research provides good information about pedestrians’ needs and evidence-based approach to promoting traffic culture, and reducing pedestrian injuries.Trial registration: Iranian Registry of Clinical Trials ≠ IRCT20180228038896N1