bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-rated resilience and mobility limitations as predictors of change in active aging during COVID-19 restrictions in Finland: a longitudinal study
Authors: Siltanen Sini , Portegijs Erja , Saajanaho Milla , Pynnönen Katja , Kokko Katja , Rantanen Taina 
Published: August 2021

AbstractSocial distancing during the COVID-19 pandemic decreased older people’s opportunities to lead an active life. The purpose of this study was to investigate whether walking difficulties predict changes in leading an active life during the COVID-19 social distancing recommendation compared to 2 years before, and whether self-rated resilience moderates this association among older people. Data were collected during social distancing recommendation in May and June 2020 and 2 years before (2017–18) among community-living AGNES study participants initially aged 75, 80, or 85 years (n = 809). Leading an active life was assessed with the University of Jyväskylä Active Aging Scale (UJACAS; total score range 0–272) and resilience with the 10-item Connor-Davidson Resilience Scale (0–40). Self-reported walking difficulties over a 2 km distance were categorized into no difficulty, difficulty, and unable to walk. The total UJACAS score declined 24.9 points (SD 23.5) among those without walking difficulty, 27.0 (SD 25.0) among those reporting walking difficulty and 19.5 (SD 31.2) among those unable to walk 2 km. When adjusted for baseline UJACAS score, those unable to walk 2 km demonstrated the greatest decline. Baseline resilience moderated this association: Higher resilience was associated with less declines in UJACAS scores among persons with or without walking difficulty, and with more declines among persons unable to walk 2 km. When opportunities for leading an active life are compromised, those with less physical and psychological resources become particularly vulnerable to further declines in activity.
Introduced populations of the garden lupine are adapted to local generalist snails but have lost alkaloid diversity
Authors: Kalske Aino , Luntamo Niko , Salminen Juha-Pekka , Ramula Satu 
Published: August 2021

AbstractIntraspecific variation in growth and defence among plant populations can be driven by differences in (a)biotic conditions, such as herbivory and resources. Introduction of species to novel environments affects simultaneously herbivory encountered by a plant and resource availability both directly and via altered competitive environment. Here, we address the question of how growth (leaf mass per area (LMA), plant size) and resistance traits (leaf alkaloids, leaf trichomes, resistance to a generalist snail) vary and covary between native and introduced populations of the garden lupine, Lupinus polyphyllus. We focused specifically on evolved differences among populations by measuring traits from plants grown from seed in a common environment. Plants from the introduced populations were more resistant against the generalist snail, Arianta arbustorum, and they had more leaf trichomes and higher LMA than plants from the native populations. The composition of alkaloids differed between native and introduced populations, with the native populations having more diversity in alkaloids among them. Resistance was positively associated with plant size and LMA across all populations. Other trait associations differed between native and introduced areas, implying that certain trade-offs may be fundamentally different between native and introduced populations. Our results suggest that, for the introduced populations, the loss of native herbivores and the alterations in resource availability have led to a lower diversity in leaf alkaloids among populations and may facilitate the evolution of novel trait optima without compensatory trade-offs. Such phytochemical similarity among introduced populations provides novel insights into mechanisms promoting successful plant invasions.
Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer
Authors: Althobiti Maryam , El-sharawy Khloud A. , Joseph Chitra , Aleskandarany Mohammed , Toss Michael S. , Green Andrew R. , Rakha Emad A. 
Published: August 2021

Abstract
Purpose
The outcome of the luminal oestrogen receptor-positive (ER +) subtype of breast cancer (BC) is highly variable and patient stratification needs to be refined. We assessed the prognostic significance of oestrogen-regulated solute carrier family 39 member 6 (SLC39A6) in BC, with emphasis on ER + tumours.

Materials and methods
SLC39A6 mRNA expression and copy number alterations were assessed using the METABRIC cohort (n = 1980). SLC39A6 protein expression was evaluated in a large (n = 670) and annotated series of early-stage (I–III) operable BC using tissue microarrays and immunohistochemistry. The associations between SLC39A6 expression and clinicopathological parameters, patient outcomes and other ER-related markers were evaluated using Chi-square tests and Kaplan–Meier curves.

Results
High SLC39A6 mRNA and protein expression was associated with features characteristic of less aggressive tumours in the entire BC cohort and ER + subgroup. SLC39A6 protein expression was detected in the cytoplasm and nuclei of the tumour cells. High SLC39A6 nuclear expression and mRNA levels were positively associated with ER + tumours and expression of ER-related markers, including the progesterone receptor, forkhead box protein A1 and GATA binding protein 3. In the ER + luminal BC, high SLC39A6 expression was independently associated with longer BC-specific survival (BCSS) (P = 0.015, HR 0.678, 95% CI 0.472‒0.972) even in those who did not receive endocrine therapy (P = 0.001, HR 0.701, 95% CI 0.463‒1.062).

Conclusion
SLC39A6 may be prognostic for a better outcome in ER + luminal BC. Further functional studies to investigate the role of SLC39A6 in ER + luminal BC are warranted.
Biomimetic mineralisation systems for in situ enamel restoration inspired by amelogenesis
Authors: Wang Jue , Liu Zhihui , Ren Bingyu , Wang Qian , Wu Jia , Yang Nan , Sui Xin , Li Lingfeng , Li Meihui , Zhang Xiao , Li Xinyue , Wang Bowei 
Published: August 2021

AbstractCaries and dental erosion are common oral diseases. Traditional treatments involve the mechanical removal of decay and filling but these methods are not suitable for cases involving large-scale enamel erosion, such as hypoplasia. To develop a noninvasive treatment, promoting remineralisation in the early stage of caries is of considerable clinical significance. Therefore, biomimetic mineralisation is an ideal approach for restoring enamel. Biomimetic mineralisation forms a new mineral layer that is tightly attached to the surface of the enamel. This review details the state-of-art achievements on the application of amelogenin and non-amelogenin, amorphous calcium phosphate, ions flow and other techniques in the biomimetic mineralisation of enamel. The ultimate goal of this review was to shed light on the requirements for enamel biomineralisation. Hence, herein, we summarise two strategies of biological minimisation systems for in situ enamel restoration inspired by amelogenesis that have been developed in recent years and compare their advantages and disadvantages.
Assessment of novel surgical procedures using decellularised muscle and bioactive ceramic: a histological analysis
Authors: Alfotawi Randa , Ahmed Raeesa , Atteya Muhammad , Mahmood Amer , Siyal Abdulazize , AlHindi Marium , El-Ghannam Ahmad 
Published: August 2021

AbstractTissue regeneration and neovascularisation in cases of major bone loss is a challenge in maxillofacial surgery. The hypothesis of the present study is that the addition of resorbable bioactive ceramic Silica Calcium Phosphate Cement (SCPC) to Declluraized Muscle Scaffold (DSM) can expedite bone formation and maturation. Two surgical defect models were created in 18 nude transgenic mice. Group 1(n = 6), with a 2-mm decortication calvarial defect, was treated with a DSM/SCPC sheet over the corticated bone as an onlay then seeded with human Mesenchymal Stromal Cells hMSC in situ. In Group 2 (n = 6), a critical size (4 mm) calvarial defect was made and grafted with DSM/SCPC/in situ human bone marrow stromal cells (hMSCs). The control groups included Group 3 (n = 3) animals, with a 2-mm decortication defect treated with an onlay DSM sheet, and Group 4 (n = 3) animals, treated with critical size defect grafted with plain DSM. After 8 weeks, bone regeneration in various groups was evaluated using histology, immunohistochemistry and histomorphometry. New bone formation and maturation was superior in groups treated with DSM/SCPC/hMSC. The DMS/SCPC scaffold has the ability to augment and induce bone regeneration and neovascularisation in cases of major bone resorption and critical size defects.
Superfast Second-Order Methods for Unconstrained Convex Optimization
Authors: Nesterov Yurii 
Published: August 2021

AbstractIn this paper, we present new second-order methods with convergence rate $$O\left( k^{-4}\right) $$

O

k

-
4

, where k is the iteration counter. This is faster than the existing lower bound for this type of schemes (Agarwal and Hazan in Proceedings of the 31st conference on learning theory, PMLR, pp. 774–792, 2018; Arjevani and Shiff in Math Program 178(1–2):327–360, 2019), which is $$O\left( k^{-7/2} \right) $$

O

k

-
7
/
2

. Our progress can be explained by a finer specification of the problem class. The main idea of this approach consists in implementation of the third-order scheme from Nesterov (Math Program 186:157–183, 2021) using the second-order oracle. At each iteration of our method, we solve a nontrivial auxiliary problem by a linearly convergent scheme based on the relative non-degeneracy condition (Bauschke et al. in Math Oper Res 42:330–348, 2016; Lu et al. in SIOPT 28(1):333–354, 2018). During this process, the Hessian of the objective function is computed once, and the gradient is computed $$O\left( \ln {1 \over \epsilon }\right) $$

O

ln

1
ϵ

times, where $$\epsilon $$
ϵ
is the desired accuracy of the solution for our problem.
Development of MA separation process with TEHDGA/SiO2-P for an advanced reprocessing
Authors: Horiuchi Yusuke , Watanabe Sou , Sano Yuichi , Takeuchi Masayuki , Kida Fukuka , Arai Tsuyoshi 
Published: August 2021

AbstractApplicability of tetra2-ehylhexyl diglycolamide (TEHDGA) impregnated adsorbent for minor actinide (MA) recovery from high level liquid waste (HLLW) in extraction chromatography technology was investigated through batch-wise adsorption and column separation experiments. Distribution ratio of representative fission product elements were obtained by the batch-wise experiments, and TEHDGA adsorbent was shown to be preferable to TODGA adsorbent for decontamination of several species. All Ln(III) supplied into the TEHDGA adsorbent packed column was properly eluted from the column, and the applicability of the adsorbent was successfully showed by this study.
Stabilization of a cantilever pipe conveying fluid using electromagnetic actuators of the transformer type
Authors: Szmidt Tomasz , Konowrocki Robert , Pisarski Dominik 
Published: August 2021

AbstractThe article presents an investigation of the stabilization of a cantilever pipe discharging fluid using electromagnetic actuators of the transformer type. With the flow velocity reaching a critical value, the straight equilibrium position of the pipe becomes unstable, and self-excited lateral vibrations arise. Supplying voltage to the actuators yields two opposite effects. First, each of the actuators attracts the pipe, thus introduces the effect of negative stiffness which destabilizes the middle equilibrium. Second, lateral vibrations change the gap in magnetic circuits of the actuators, which leads to oscillations of magnetic field in the cores and the electromagnetic phenomena of induction and hysteresis that impede the motion of the pipe. The combination of these two non-linear effects is ambiguous, so the problem is explored both theoretically and experimentally. First, a mathematical model of the system in form of a partial differential equation governing the dynamics of the pipe coupled with two ordinary differential equations of electro-magnetodynamics of the actuators is presented. Then, the equation of the pipe’s dynamics is discretized using the Galerkin procedure, and the resultant set of ordinary equations is solved numerically. It has been shown that the overall effect of actuators action is positive: the critical flow velocity has been increased and the amplitude of post-critical vibrations reduced. These results have been validated experimentally on a test stand.
An audio enhancement system to improve intelligibility for social-awareness in HRI
Authors: Martínez-Colón Antonio , Viciana-Abad Raquel , Perez-Lorenzo Jose Manuel , Evers Christine , Naylor Patrick A. 
Published: August 2021

AbstractImproving the ability to interact through voice with a robot is still a challenge especially in real environments where multiple speakers coexist. This work has evaluated a proposal based on improving the intelligibility of the voice information that feeds an existing ASR service in the network and in conditions similar to those that could occur in a care centre for the elderly. The results indicate the feasibility and improvement of a proposal based on the use of an embedded microphone array and the use of a simple beamforming and masking technique. The system has been evaluated with 12 people and results obtained for time responsiveness indicate that the system would allow natural interaction with voice. It is shown to be necessary to incorporate a system to properly employ the masking algorithm, through the intelligent and stable estimation of the interfering signals. In addition, this approach allows to fix as sources of interest other speakers not located in the vicinity of the robot.
Drivers, pressures, and state responses to inform long-term oil sands wetland monitoring program objectives
Authors: Ficken Cari D. , Connor Stephanie J. , Rooney Rebecca , Cobbaert Danielle 
Published: August 2021

AbstractBoreal peatlands provide numerous ecosystem services ranging from carbon sequestration to the provisioning of habitat for species integral to Indigenous communities. In the Oil Sands Region of Alberta, Canada, human development related to oil and gas extraction occurs in a wetland-dominated landscape. Wetland monitoring programs can determine the extent to which development impacts wetlands, but existing monitoring programs focus on characterizing biodiversity across the region and on compliance and regulatory monitoring that assumes impacts from oil sands development do not extend past lease boundaries. This is unlikely to be true since some impacts, such as particulate deposition, can extend over large areas contingent on local weather and topography. To inform the development of a new regional wetland monitoring program to assess the cumulative effects of oil sands development on wetlands, we synthesized information on the scope of wetland research across the Oil Sands Region, including the anthropogenic stressors that impact wetlands and the wetland characteristics sensitive to different disturbances. We developed a conceptual model linking human development with wetland ecology in the region to make explicit the relationships among oil sands development stressors and different components of wetland ecosystems. By highlighting testable relationships, this conceptual model can be used as a collection of hypotheses to identify knowledge gaps and to guide future research priorities. relationships among We found that the majority of studies are short-term (77% were ≤ 5 years) and are conducted over a limited spatial extent (82% were sub-regional). Studies of reclaimed wetlands were relatively common (18% of all tests); disproportionate to the occurrence of this wetland type. Results from these studies likely cannot be extrapolated to other wetlands in the region. Nevertheless, the impacts of tailings contaminants, wetland reclamation activities, and surface water chemistry are well-represented in the literature. Research on other types of land disturbance is lacking. A coordinated, regional monitoring program is needed to gain a complete understanding of the direct and indirect impacts of human development in the region and to address remaining knowledge gaps.
Challenges in LC–MS-based metabolomics for Alzheimer’s disease early detection: targeted approaches versus untargeted approaches
Authors: Reveglia Pierluigi , Paolillo Carmela , Ferretti Gabriella , De Carlo Armando , Angiolillo Antonella , Nasso Rosarita , Caputo Mafalda , Matrone Carmela , Di Costanzo Alfonso , Corso Gaetano 
Published: August 2021

Abstract
Background
Alzheimer's disease (AD) is one of the most common causes of dementia in old people. Neuronal deficits such as loss of memory, language and problem-solving are severely compromised in affected patients. The molecular features of AD are Aβ deposits in plaques or in oligomeric structures and neurofibrillary tau tangles in brain. However, the challenge is that Aβ is only one piece of the puzzle, and recent findings continue to support the hypothesis that their presence is not sufficient to predict decline along the AD outcome. In this regard, metabolomic-based techniques are acquiring a growing interest for either the early diagnosis of diseases or the therapy monitoring. Mass spectrometry is one the most common analytical platforms used for detection, quantification, and characterization of metabolic biomarkers. In the past years, both targeted and untargeted strategies have been applied to identify possible interesting compounds.

Aim of review
The overall goal of this review is to guide the reader through the most recent studies in which LC–MS-based metabolomics has been proposed as a powerful tool for the identification of new diagnostic biomarkers in AD. To this aim, herein studies spanning the period 2009–2020 have been reported. Advantages and disadvantages of targeted vs untargeted metabolomic approaches have been outlined and critically discussed.
Tenebrio molitor in the circular economy: a novel approach for plastic valorisation and PHA biological recovery
Authors: Sangiorgio Paola , Verardi Alessandra , Dimatteo Salvatore , Spagnoletta Anna , Moliterni Stefania , Errico Simona 
Published: August 2021

AbstractThe increase in the world population leads to rising demand and consumption of plastic raw materials; only a small percentage of plastics is recovered and recycled, increasing the quantity of waste released into the environment and losing its economic value. The plastics represent a great opportunity in the circular perspective of their reuse and recycling. Research is moving, on the one hand, to implement sustainable systems for plastic waste management and on the other to find new non-fossil-based plastics such as polyhydroxyalkanoates (PHAs). In this review, we focus our attention on Tenebrio molitor (TM) as a valuable solution for plastic biodegradation and biological recovery of new biopolymers (e.g. PHA) from plastic-producing microorganisms, exploiting its highly diversified gut microbiota. TM’s use for plastic pollution management is controversial. However, TM microbiota is recognised as a source of plastic-degrading microorganisms. TM-based plastic degradation is improved by co-feeding with food loss and waste as a dietary energy source, thus valorising these low-value substrates in a circular economy perspective. TM as a bioreactor is a valid alternative to traditional PHA recovery systems with the advantage of obtaining, in addition to highly pure PHA, protein biomass and rearing waste from which to produce fertilisers, chitin/chitosan, biochar and biodiesel. Finally, we describe the critical aspects of these TM-based approaches, mainly related to TM mass production, eventual food safety problems, possible release of microplastics and lack of dedicated legislation.
A New Method for Landmark-Based Studies of the Dynamic Stability of Growth, with Implications for Evolutionary Analyses
Authors: Bookstein Fred L. 
Published: August 2021

AbstractA matrix manipulation new to the quantitative study of develomental stability reveals unexpected morphometric patterns in a classic data set of landmark-based calvarial growth. There are implications for evolutionary studies. Among organismal biology’s fundamental postulates is the assumption that most aspects of any higher animal’s growth trajectories aredynamically stable,resilient against the types of small but functionally pertinent transient perturbations that may have originated in genotype, morphogenesis, or ecophenotypy. We need an operationalization of this axiom for landmark data sets arising from longitudinal data designs. The present paper introduces a multivariate approach toward that goal: a method for identification and interpretation of patterns of dynamical stability in longitudinally collected landmark data. The new method is based in an application of eigenanalysis unfamiliar to most organismal biologists: analysis of a covariance matrix of Boas coordinates (Procrustes coordinates without the size standardization) against their changes over time. These eigenanalyses may yield complex eigenvalues and eigenvectors (terms involving$$i=\sqrt{-1}$$i=-1); the paper carefully explains how these are to be scattered, gridded, and interpreted by their real and imaginary canonical vectors. For the Vilmann neurocranial octagons, the classic morphometric data set used as the running example here, there result new empirical findings that offer a pattern analysis of the ways perturbations of growth are attenuated or otherwise modified over the course of developmental time. The main finding, dominance of a generalized version of dynamical stability (negative autoregressions, as announced by the negative real parts of their eigenvalues, often combined with shearing and rotation in a helpful canonical plane), is surprising in its strength and consistency. A closing discussion explores some implications of this novel pattern analysis of growth regulation. It differs in many respects from the usual way covariance matrices are wielded in geometric morphometrics, differences relevant to a variety of study designs for comparisons of development across species.
Comparison of Serum, Plasma, and Liver Zinc Measurements by AAS, ICP-OES, and ICP-MS in Diverse Laboratory Settings
Authors: Hall Andrew G. , King Janet C. , McDonald Christine M. 
Published: August 2021

AbstractProgress improving zinc nutrition globally is slowed by limited understanding of population zinc status. This challenge is compounded when small differences in measurement can bias the determination of zinc deficiency rates. Our objective was to evaluate zinc analytical accuracy and precision among different instrument types and sample matrices using a standardized method. Participating laboratories analyzed zinc content of plasma, serum, liver samples, and controls, using a standardized method based on current practice. Instrument calibration and drift were evaluated using a zinc standard. Accuracy was evaluated by percent error vs. reference, and precision by coefficient of variation (CV). Seven laboratories in 4 countries running 9 instruments completed the exercise: 4 atomic absorbance spectrometers (AAS), 1 inductively coupled plasma optical emission spectrometer (ICP-OES), and 4 ICP mass spectrometers (ICP-MS). Calibration differed between individual instruments up to 18.9% (p < 0.001). Geometric mean (95% CI) percent error was 3.5% (2.3%, 5.2%) and CV was 2.1% (1.7%, 2.5%) overall. There were no significant differences in percent error or CV among instrument types (p = 0.91, p = 0.15, respectively). Among sample matrices, serum and plasma zinc measures had the highest CV: 4.8% (3.0%, 7.7%) and 3.9% (2.9%, 5.4%), respectively (p < 0.05). When using standardized materials and methods, similar zinc concentration values, accuracy, and precision were achieved using AAS, ICP-OES, or ICP-MS. However, method development is needed for improvement in serum and plasma zinc measurement precision. Differences in calibration among instruments demonstrate a need for harmonization among laboratories.