bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral therapies for glioblastoma and high-grade gliomas in adults: a systematic review
Authors: Wang Joshua L. , Scheitler Kristen M. , Wenger Nicole M. , Elder J. Bradley 
Published: February 2021

OBJECTIVEHigh-grade gliomas (HGGs) inevitably recur and progress despite resection and standard chemotherapies and radiation. Viral therapies have emerged as a theoretically favorable adjuvant modality that might overcome intrinsic factors of HGGs that confer treatment resistance.METHODSThe authors present the results of systematic searches of the MEDLINE and ClinicalTrials.gov databases that were performed for clinical trials published or registered up to July 15, 2020.RESULTSFifty-one completed clinical trials were identified that made use of a virus-based therapeutic strategy to treat HGG. The two main types of viral therapies were oncolytic viruses and viral vectors for gene therapy. Among clinical trials that met inclusion criteria, 20 related to oncolytic viruses and 31 to gene therapy trials. No oncolytic viruses have progressed to phase III clinical trial testing, although there have been many promising early-phase results and no reported cases of encephalitis or death due to viral therapy. Three phase III trials in which viral gene therapy was used have been completed but have not resulted in any FDA-approved therapy. Recent efforts in this area have been focused on the delivery of suicide genes such as herpes simplex virus thymidine kinase and cytosine deaminase.CONCLUSIONSDecades of research efforts and an improving understanding of the immunomodulatory effects of viral therapies for gliomas are informing ongoing clinical efforts aimed at improving outcomes in patients with HGG. The available clinical data reveal varied efficacy among different virus-based treatment strategies.
Асоціація поліморфізму генів BCL-2, CTLA-4, APO-1/Fas з активністю проліферації й апоптозу в тиреоїдній тканині хворих із вузловими формами зоба на тлі автоімунного тиреоїдиту та аденоми щитоподібдної залози
Authors: Sheremet M.I. , Sydorchuk L.P. , Shidlovskyi V.O. , Shidlovskyi O.V. , Bedenyuk A.D. , Kurochkin G.S. , Tkachuk N.P. , Gyrla Yu.V. 
Published: February 2021

Мета — вивчення показників апоптозу та проліферативної активності в тканині щитоподібної залози (ЩЗ) у хворих на вузловий зоб на тлі автоімунного тиреоїдиту (ВЗАІТ) та аденому ЩЗ (АЩЗ) порівняно з морфологічно незміненою тканиною, підрахунок кількості імунореактивних клітин, які експресують зазначені маркери. Матеріал і методи. Проводили порівняльний аналіз процесів апоптозу та проліферації в тканині ЩЗ у хворих на ВЗАІТ та АЩЗ і в морфологічно незміненій тканині ЩЗ шляхом дослідження експресії/щільності маркерів Fas/FasL, Bcl‑2, p53 і Ki‑67 на тиреоцитах у ділянках лімфоїдної інфільтрації та їх деструкції, а також у морфологічно незмінених ділянках тиреоїдної тканини (контроль). Підраховували кількість імунореактивних клітин, які експресують зазначені маркери, з використанням імуногістохімічного методу з урахуванням поліморфізму генів BCL‑2 (rs17759659), CTLA‑4 (rs231775) і APO‑1/Fas (rs2234767). Результати. Встановлено, що у хворих на ВЗАІТ та АЩЗ активуються декілька ланок програмованого кілінгу тиреоцитів із перевагою Fas-індукованого апоптозу, який асоціюється з промотором гена BCL‑2 (rs17759659) (F=25,33; p<0,001) і майже у 6 разів слабше — з промотором гена CTLA‑4 (rs231775) (F=4,23; p=0,017) через виражену експресію Fas і FasL на поверхні клітин у ділянках лімфоїдної інфільтрації та деструкції тиреоцитів (сильніше в носіїв GG-генотипу гена BCL‑2 — на 18,54% і 36,18% відповідно), що свідчить про ініціацію зовнішнього шляху апоптозу через каспазний механізм (ефекторну каспазу 8).
Корекція функціонального статусу ендотелію як потенційної мішені у хворих із серцево-судинними захворюваннями та метаболічними розладами
Authors: Kuryata A.V. , Grechanyk M.M. 
Published: February 2021

Серцево-судинні (ССЗ) та обмінні захворювання (такі як ожиріння та цукровий діабет) наразі є основними проблемами зі здоров’ям у всьому світі. Одним із найважливіших патофізіологічних зв’язків між цими станами є наявність оксиду азоту (NO), який постійно виробляється з умовно незамінної амінокислоти L-аргініну. NO є важливою паракринною речовиною, яка продукується ендотелієм для регуляції судинного тонусу. Розвиток і прогресування атеросклерозу пов’язано з дисфункцією ендотелію та зниженням біодоступності NO. Встановлено, що ожиріння також пов’язано зі зменшенням продукції NO, викликаної порушенням біодоступності його субстрату — аргініну, а збільшенню вмісту аргініну в ендотелії запобігає гіпертензія, яка часто поєднується з ожирінням. L-аргінін є амінокислотою, необхідною ферменту ендотеліальній NO-синтазі (eNOS) для продукції NO. Мета — бібліографічний огляд наукових публікацій. Результати. У даному огляді розглянуто фізіологічну роль NO у функціонуванні різних системорганізму. Наведено дані щодо метаболізму L-аргініну, його біодоступності та механізмів дії. Проаналізовано літературні дані про ефективність і безпечність застосування різних доз L-аргініну в пацієнтів з ожирінням, цукровим діабетом, інсулінорезистентністю (ІР) та артеріальною гіпертензією. Висновки. Питання дози та тривалості застосування аргініну сьогодні вимагають подальшого вивчення. Результати багатьох досліджень, в яких оцінювали використання аргініну в дорослих з ожирінням, дозволяють припустити, що аргінін може бути безпечним, недорогим і ефективним терапевтичним засобом за ожиріння та позитивно впливає на корекцію метаболічних процесів, а саме на ІР. Ефективність застосування L-аргініну як додаткової терапії до основної схеми лікування отримала підтвердження за артеріальної гіпертензії, цукрового діабету та ІР. Аналіз літератури свідчить, що застосування L-аргініну є безпечним у діапазоні до 30 г на добу, хоча в більшості досліджень використовували дози від 6 до 12 г на добу.
RUANG PROYEKTIF KOMPLEKS 〖CP〗^n ADALAH MANIFOLD KOMPLEKS
Authors: Agustito Denik , Taufiq Irham , Setiana Dafid Slamet , Purwoko Riawan Yudi 
Published: February 2021

<p>The purpose of this paper to determine the complex projective space as a complex manifold is to calculate the cohomology of the coherent sheaves of . The research method in this paper is to construct an -dimensional complex projective space, namely and then the n-dimensional complex projective space, namely , is a complex manifold. The result of this research is the -dimensional complex projective space, namely is a complex and compact manifold.</p>
A crítica de Heidegger à estética em A origem da obra de arte (Der Ursprung des kunstwerkes, 1936)
Authors: Alves dos Santos Ribeiro Luan 
Published: February 2021

O seguinte artigo tem por objeto apresentar e desenvolver a crítica de Martin Heidegger à estética a partir do ensaio A Origem da Obra de Arte (Der Ursprung des Kunstwerkes, 1936). Para o pensamento heideggeriano a estética, enquanto herdeira dos paradigmas metafísicos, mata o que há de essencial na arte (a sua verdade ontológica) ao tomá-la fundamentalmente como um objeto capaz de provocar e impactar a sensibilidade do sujeito contemplador. Conforme acompanharemos em nosso percurso, Heidegger traça a origem (Ur-sprung) de tal concepção nos primeiros sistemas filosóficos ocidentais com Platão e Aristóteles e o seu desenvolvimento nos momentos iniciais da modernidade com Descartes e os demais herdeiros de seu pensamento. Uma vez que ao concebermos as obras de artes já nos encontramos no cerne de sedimentações históricas, faz-se necessário mergulhar em tais sedimentações em vista de desenvolver as potencialidades ali adormecidas. É esse o convite que Heidegger nos faz e que aqui também fazemos ao leitor.
Teaching Descriptive Text Using Pictures to Improve Students’ Reading Comprehension
Authors: Nggolaon Desriani , Sari Puput Eka 
Published: February 2021

The purpose of this research is to know whether the pictures in descriptive text can improve students’ reading comprehension or not at the Tenth Grade Students in SMA Negeri 1 Luwuk. The research design in this research was quasi-experimental using non-equivalent control group design. The Independent variable of this research was pictures and the dependent variable was students’ reading comprehension. The Population of this research all students of IPA in SMA Negeri 1 Luwuk of the Tenth Grade were about 216 students, each class consisted of 36 students and the sample of this research were X MIPA 1 and X MIPA 2. The instrument used of this research was test. This research has two classes, experimental class and was control class. The data were taken by giving pre-test and post-test both of classes. The data indicated that, there was a significant difference between students’ pre-test and post-test in the experimental class. The mean score of students’ pre-test of experimental class was (57.02) and the mean score of post-test was (77.97). In experimental class, mean score of post-test was higher than mean score of pre-test. The result of the calculation statistical hypothesis test showed tvalue was higher than ttable (6.618 1.667) where the formula of significance level df = 005. Therefore, it was concluded that there was a significance effect of using pictures to improve student’ reading comprehension in teaching descriptive text at the Tenth Grade of SMA Negeri 1 Luwuk.Keywords: Pictures; Students’ Reading Comprehension; Descriptive text.
Gambaran Pelaksanaan Serah Terima Antar Shift di Rumah Sakit X Jakarta
Authors: Cahyaningtyas Amalia , Handayani Hanny , Yatnikasari Aat 
Published: February 2021

A description of handover processes in hospital: A survey from Jakarta, IndonesiaBackground: Handover at the change of nurse shift is one of an important role in patient safety and continuiting quality of care.Purpose: To optimization of implementation of handover processes in hospital: A survey from Jakarta, IndonesiaMethod: An analysis study with approach fishbone diagram, start with filling in questionnaires, observations and interviews and then analyzed using fishbone diagrams. Based on fishbone diagrams, the problem was obtained that the implementation of handover of patient patients was not optimal.Results: To optimize the implementation of handover, implementation was carried out in the form of improving SPO, improving nurses' effective communication with SBAR and making role play video handover.Conclusion: The result is the handover can be optimal with the role and function of management of the head nurse especially a directing role. Recommendations given by follow up and revising the hand over standars, make a pilot project nursing ward and evaluate the implementation of the patient's handover through regular supervision.Keywords: Fishbone Diagram; Handover; Head Nurse; Optimization; DirectingPendahuluan: Serah terima perawat antar shift jaga merupakan salah satu komponen penting dalam mencapai keselamatan pasien dan mempertahankan kualitas asuhan.Tujuan: Meningkatkan optimalisasi fungsi pengarahan kepala ruang dalam pelaksanaan serah tertima antar shift di RS X Jakarta.Metode: Menggunakan study analysis situasi dengan pendekatan diagram tulang ikan, dimulai dengan mengisi kuesioner, observasi dan wawancara dan kemudian dianalisis menggunakan diagram tulang ikan. Berdasarkan diagram tulang ikan, masalah diperoleh bahwa pelaksanaan serah terima pasien pasien belum optimal.Hasil: Untuk mengoptimalkan pelaksanaan serah terima, implementasi dilakukan dalam bentuk meningkatkan SPO, meningkatkan komunikasi efektif perawat dengan SBAR dan membuat role play video serah terima.Simpulan: Hasilnya adalah serah terima dapat dioptimalkan dengan peran dan fungsi manajemen kepala ruang khususnya fungsi pengarahan. Rekomendasi yang diberikan dengan menindaklanjuti dan merevisi SOP serah terima, membuat ruang percontohan dan mengevaluasi pelaksanaan serah terima pasien melalui pengawasan rutin.
Pengetahuan dan Perilaku Safety Riding Siswa SMA
Authors: Wahyuningsih Indri , Ramdana Syahra 
Published: February 2021

Knowledge and Safety Riding Behavior Among High School StudentsBackground: Young people are the most involved in traffic accidents in Indonesia, because of the risky driving style. High school students belong to one of the young age groups with an average age of 15-18 years. To ensure traffic safety, a safety riding program was established which includes disciplinary behavior in driving rules and procedures. Own behavior is influenced by factors, one of which is knowledge. Knowledge as a stimulus or stimulus and becomes the basis for action.Purpose: To find the relationship between knowledge and safety riding behavior among high school students.Method: This study used an analytical observational method with a cross sectional approach, and a simple radom sampling technique. The sample was obtained as many as 164 respondents. Then the data were analyzed using spearman rank correlation with a significance level of 5%.Results: Most of the respondents have good knowledge (67.1%), as well as behavior, the majority of respondents have safe driving behavior (82.9%). The results of the spearman rank correlation analysis showed a p-value of 0.120 or greater than a significance of 5% (p> 0.05).Conclusion: There is no significant relationship between knowledge and safety riding behavior.Keywords: Knowledge; Safety riding behavior; High school studentsPendahuluan: Kalangan usia muda merupakan yang paling banyak terlibat kasus kecelakaan lalu lintas di Indonesia, diakibatkan gaya berkendara yang beresiko. Siswa SMA termasuk salah satu kelompok usia muda dengan usia rata-rata 15-18 tahun. Untuk menjamin keselamatan lalu lintas, dibentuk program safety riding yang mencakup perilaku disiplin dalam aturan dan tatacara berkendara. Perilaku sendiri dipengaruhi faktor pembentuk salah satunya pengetahuan. Pengetahuan sebagai ransangan atau stimulus dan menjadi dasar dalam bertindak. Tujuan: penelitian ini ingin mencari hubungan pengetahuan dengan perilaku safety riding pada siswa SMA.Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional, dan teknik sampling simple radom sampling. Sampel diperoleh sebanyak 164 responden. Kemudian data dianalisis menggunakan korelasi spearman rank dengan tingkat kemaknaan 5%.Hasil: Sebagian besar responden memiliki pengetahuan dengan kategori baik (67,1%), begitupun dengan perilaku, mayoritas responden memiliki perilaku berkendara aman (82,9%). Hasil analisis korelasi spearman rank didapatkan p-value 0,120 atau lebih besar dari kemaknaan 5% (p>0,05).Simpulan: Tidak terdapat hubungan signifikan antara pengetahuan dengan perilaku safety riding.
قواعد أصول الحديث في رسالة الإمام الشافعي محمد بن إدريس رحمه الله تعالى
Authors: Yasser Mohammad Nouri Aldeirshawi  
Published: February 2021

This research is an inductive analytical study on the fundamentals of the science of Hadith extrapolated by Imam Al-Shāfi’ī (May Allah have mercy on him) in his book Ar-Risālah (The Epistle) along with the discussion of later scholars. In this research, I identified all these principles and theories that are related to the science of Hadith that were discussed in the book. In addition, I made a thorough study on the scholars’ position with their views, opinions and understandings to them. In the end, I came across some findings, most important among them is that, Imam Al-Shāfi’ī was the first to establish the fundamentals theories of the science of Hadith, as he was the first to coined its terminologies, and discussed the theories in such a way never preceded by any scholar. These were later, the subsequent scholars relied upon them in their writings.
Studying the Effect of Potassium Amyl Xanthate Surfactant on Fe, Cu and U Ions for the Pretreatment of Abu Zeneima Sulphate Leach Liquor
Authors: Ahmed Sherien Hussein , El Gammal Entesar Mohamed , Amin Mostafa Ibrahim , Yousef Walid Mohamed 
Published: February 2021

In this study, batch experiments were performed to study the behavior of potassium amyl xanthate surfactant on Fe, Cu and U ions for the pretreatment of Abu Zeneima sulphate leach liquor. Various parameters, such as amount of potassium amyl xanthate, pH, stirring time, sample volume to potassium amyl xanthate mass (v/m ratio) and temperature were tested to determine the optimum conditions. The numerical results obtained support the experimental data on decreasing the iron and copper values where 0.1 g potassium amyl xanthate could remove 86.8 mg Fe and 0.98 mg Cu from the studied sulphate solution with no effect on uranium content. FTIR spectroscopy and XRF analysis were used for investigation.
Factors Influencing Low Enrollment in a Community Based Health Insurance Scheme, Karachi, Pakistan: a Mixed Methods Case Study
Authors: Khuwaja Hussain Maqbool Ahmed , Karmaliani Rozina , Mistry Rozina , Malik Muhammad Ashar , Sikandar Rozina 
Published: February 2021

Background: There is strong evidence on the potential of the Community Based Health Insurance (CBHI) schemes to facilitate access to healthcare and offer financial protection against the cost of illness for people excluded from formal insurance systems. However, enrollment in the Family Health Insurance scheme has remained low and there has been substantial dropout from the initial enrollment of the scheme’s insured members.
Aim:This research aimed at exploring factors influencing enrollment of community members in a CBHI scheme.
Methods:A mixed methods case studycomprisingqualitative phase of 10 Key Informant Interviews and 18 In-depth Interviews, and quantitative phase of 190 households: 96 insured and 94 uninsured were involved. Qualitative analysis was done using open coding while descriptive analysis was done for quantitative data.
Results:Lack of awareness regarding insurance, lack of trust in management, unaffordability of insurance premiums, limited coverage of services in insurance plans, ambiguity regarding pre-existing conditions, negative marketing by drop-outs, and exclusion of vulnerable groups were some of the common reasons among uninsured group. Insured members of the scheme also had little knowledge about the scheme.
Conclusions:The major reason for enrollment was the influence of community leader’s guidance. Stakeholders believed in modification of marketing strategies and innovations in increasing community awareness.
Bangladesh Journal of Medical Science Vol.20(2) 2021 p.293-301
Facial golden ratio and facial appearance among medical students of Jouf University
Authors: Basri Rehana , Salman Alaa Nemer , Aldoghmany Sabha Ali , Bagi Wurud Saud , Alrwaili WedadMotarrad , Almazyad Abdul rahman Bader A , Almndil Nawaf Abdal Wahab , Alam Mohammad Khursheed 
Published: February 2021

Background: All human faces are unique and contribute to individual identity. The face is oneof the most fundamental parts of the body for self-recognition. Objectives: To measure the facialgolden ratio (FGR) and facial appearance (FA) of medical students of Jouf University, SaudiArabia.
Methodology: This is a cross sectional study, facial height (FH) and facial width (FW)of each participant were measured by digital verniercalliper. All measurements were done bytwo researchers, if the measurements are equal or nearby, then mean value are considered andassessment of facial awareness are done by a validated structured questionnaire. Data analysiswas carried out using the Statistical Package for Social Sciences version 23 (SPSS Inc., Chicago,IL, USA).
Results: Mean FGR value of the males and females are 1.64 and 1.55 respectively.This study revealed highly significant disparities among genders. The male participant has closeresembles with FGR in comparison to females. There was no significant difference betweenupper FH (57.74), Middle FH (55.16) and Lower FH (56.65) among Saudi, Jordan and Syrianparticipant. The females were significantly more satisfied with their eyelids and eyes than males,and their significant different was p=0.014 and 0.002, respectively.
Conclusions: Majoritypopulation, both male and female having a normal face and satisfied with their face’s variables.The male participant has close resembles with the FGR.
Bangladesh Journal of Medical Science Vol.20(2) 2021 p.334-341
Gender-based differences in the effectiveness of antihypertensive therapy with losartan compared with enalapril
Authors: Cam Truong Dinh , Berestova Anna , Lopatina Natalia , Pashanova Olga 
Published: February 2021

Objective: Today there is a limited number of gender-based characteristics of the enalapril and losartanadministration in order to correct blood pressure in patients with arterial hypertension.The aim ofthe study was to compare the effectiveness of enalapril and losartan for blood pressure correcting inpatients with arterial hypertension (AH), depending on gender.
Materials and methods: The studywas carried out in 2019 at Military Hospital 175 in Ho Chi Minh city, Vietnam. To achieve this goal,100 people were included in the study (50 females in the menopause and 50 males) with grade I-IIarterial hypertension aged 50 to 60 years. Patients with hypertension were divided into the followinggroups: group 1A – 25 males, who received enalapril 20 mg/d and 12.5 mg/d hydrochlorothiazideonce per day as antihypertensive therapy; group 1B – 25 males, who received losartan 50 mg/d andhydrochlorothiazide 12.5 mg/d once per day; group 2A – 25 females, who received enalapril 20 mg/dand hydrochlorothiazide 12.5 mg/d once per day; group 2B – 25 females, who received losartan 50mg/d and hydrochlorothiazide 12.5 mg/d once per day. The follow-up was 12 weeks.
Results anddiscussion: The study showed that antihypertensive therapy with losartan is more effective in femalescompared with enalapril, as evidenced by a significant SBP decrease by 21.1% (p<0.05) at the endof treatment with losartan in females versus 18.6% (p<0.05) when using enalapril with the presenceof a statistically significant intergroup difference in the indicator (p<0.05).
Conclusion: Our resultsindicate the presence of a gender difference in the antihypertensive effect of losartan and enalapril.
Bangladesh Journal of Medical Science Vol.20(2) 2021 p.348-355
Efficacy of Cyriax Physiotherapy versus Cyriax and low level Laser Therapy on pain and grip strength in Lateral Epicondylitis
Authors: Sharma Sunita , Gupta Nitin , Joshi Sandeep , Bala Rosy , Sharma Ruby 
Published: February 2021

Objective: The study was designed to evaluate the efficacy of Cyriax physiotherapy versus Cyriaxand Low Level Laser Therapy to compare these techniques in reducing pain and improving gripstrength in patients with lateral epicondylitis.
Methodology: The study population included 30patients of lateral epicondylitis (signs and symptoms present for more than 6 weeks) diagnosedin outpatient and indoor facilities of MM Hospital, Mullana. The subjects were selected bymeans of simple random sampling. After fulfilling the inclusion and exclusion criteria, thepatients were randomly allocated in two groups: Group A and Group B. Group A received cyriaxphysiotherapy alone whereas Group B patients were subjected to combined Cyriax and low levelLaser therapy. Baseline measurements of pain and grip strength were taken before treatmentand then at 3 weeks respectively.
Results: Our findings showed that there was significantlyhigher improvement in pain and grip strength in Group B (patients receiving combination ofcyriax therapy with low dose laser therapy) as compared to Group A (p<0.05).
Conclusion:Cyriax physiotherapy and low level laser therapy were effective in reducing pain and improvinggrip strength after the treatment sessions. But benefits of cyriax physiotherapy with low levellaser therapy in lateral epicondylitis patients are significantly higher as compared to cyriaxphysiotherapy alone over a three week period. Hence, cyriax with low level laser therapy isproved to be a better treatment.
Bangladesh Journal of Medical Science Vol.20(2) 2021 p.356-360