bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental murine non-alcoholic steatohepatitis is associated with behavioural, cognitive, and peripheral neuronal dysfunction
Authors: Prikhodko V. A. , Orlyakhina D. A. , Petrova V. D. , Karev V. E. , Ivkin D. Yu. , Napalkova S. M. , Okovityi S. V. 
Published: December 2024

Introduction. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), the leading causes of chronic liver disease worldwide, are associated with a wide range of psychoneurological complications and conditions. However, the causal relationship between liver and nervous system disease remains poorly understood, which warrants the development of clinically relevant and valid animal models thereof.Aim. The objective of this work was to characterize the short- and long-term psychoneurological and peripheral neuronal deficits that complicate different stages of NAFLD/NASH in mice.Materials and methods. 68 adult male C57Bl/6 mice were randomized into Control or NASH groups. NASH was induced over 3 (Experiment 1) or 6 (Experiment 2) mo using a combined model including a high-fat diet and low doses of carbon tetrachloride. Control group received standard chow, drinking water, and equivolume normal saline. Animal behaviour was assessed by the Open field (OF), Elevated plus maze (EPM), and Light/dark box (LDB) tests at 1, 2, 3, and 6 mo of NASH induction. Visuospatial memory was assessed by the Spontaneous alternation in the T-maze and Novel object recognition tests at 1, 2, and 3 mo of NASH modelling, and using the Barnes maze at 6 mo of NASH induction. Following 3 mo of NASH induction, needle electroneuromyography (ENMG) was performed on the gastrocnemius and biceps muscles with the electrical stimulation of the sciatic and musculocutaneous nerves, respectively. Liver pathology was confirmed by histomorphology. Statistical analysis was performed using Prism 10.2.3 and R 4.2.3 with RStudio 2024.09.0.Results and discussion. Experimental modelling was associated with poorer overall survival (p < 0.05, p < 0.01) and substantial evidence of liver injury, i.e. cholestatic hepatitis, medio- and macrovesicular steatosis, focal necrosis and fibrosis of varying severity (p < 0.05, p < 0.01). Mice with NASH exhibited markers of elevated anxiety in the OF, EPM, and LDB tests (p < 0.05, p < 0.01), which were mostly specific to the very onset of liver disease (1 mo) as well as its later stages (6 mo). NASH was also associated with a significant decrease in spontaneous alternation at 3 mo (p < 0.01), negative object disrimination at 2 mo (p < 0.05), and poorer memory retention in the Barnes maze (p < 0.05, p < 0.01) compared with Control. ENMG data analysis revealed significantly lower peak M-wave amplitudes (p < 0.01) and threshold currents (p < 0.05) in the gastrocnemius, and increased peak latency in the biceps in the NASH group (p < 0.05).Сonclusion. Experimental alimentary/toxic NASH in male C57Bl/6 mice is associated with increased anxiety-like behaviour, visuospatial memory acquisition and retention impairment, and evidence of axonal and demyelinating peripheral motor neuropathy.
Comparative efficacy study of experimental chronic heart failure
Authors: Ivkin D. Yu. , Zelentsova A. B. , Krasnova M. V. , Karpov A. A. , Pazheltsev V. V. , Napalkova S. M. , Terninko I. I. , Titovich I. A. , Okovitiy S. V. 
Published: December 2024

Introduction. Combination therapy of chronic heart failure (CHF) is an urgent and important treatment strategy, as it allows to achieve an improvement in the prognosis, optimal control of the symptoms of the disease and an increase in the quality of life of patients.Aim. Comparison of the effectiveness of the malonic acid derivative ethmaben, the sodium-glucose cotransporter inhibitor empagliflozin and their combinations with the variability of the starting drug in experimental post-infarction chronic heart failure in rats.Materials and methods. In a model of post-infarction chronic heart failure, reproduced by permanent ligation of the left coronary artery in rats, an echocardiographic study was used to compare etmaben and empagliflozin monotherapy with a combined regimen of these drugs. The concentration of etmaben in the myocardium was assessed by HPLC.Results and discussion. Antagonism between etmaben and empagliflozin was revealed, manifested by a decrease in the effect of combination therapy in relation to any of the components, a decrease in the concentration of malonic acid derivative in the myocardium under the action of a type 2 sodium-glucose cotransporter inhibitor was shown.Conclusion. Based on the data obtained, additional studies of pharmacokinetics and pharmacodynamics of etmaben were planned.
Development of the suspension system and their potential in improving the tactical and technical characteristics of armored combat vehicles
Authors: Duschenko Vladyslav , Nanivskyi Roman 
Published: December 2024

This article analyzes the improvement of the main indicators of mobility and reduction of energy losses in the damping devices of armored fighting vehicles, and also presents the use of friction shock absorbers instead of hydro shock absorbers. Increasing the protection indicators with the help of traditional measures leads to an increase in the weight of the AFV, which reduces the average speed of the vehicle on the ground and increases the likelihood of its defeat on the battlefield. The issues of ensuring compliance and coordination of the characteristics of the recuperation system with the characteristics of the required damping in the suspension system, which exerts an impact, reducing the probability of hitting the striking elements by ensuring high mobility, maneuverability and evasion of the hull, are considered.
The functional relationship between the improvement of the suspension system, the mutual agreement of its characteristics with the characteristics of the weapon complexes, power plant and transmission and the improvement of the indicators of the main groups of tactical and technical characteristics of armored fighting vehicles has been established. Based on the analysis of development trends, the potential was assessed and the main directions of the development of the suspension system were formulated, which will fundamentally affect the fulfillment of modern and promising operational and tactical requirements and will lead to a significant increase in the tactical and technical characteristics of armored fighting vehicles. These are: the use of hydropneumatic suspensions, the introduction of non-traditional control systems for the characteristics of suspension nodes based on the use of "intelligent" materials, in particular magnetorheological elastomers, the use of friction shock absorbers and new kinematic suspension schemes with significantly increased dynamic travel, as well as the use of energy recovery systems of suspension damping devices.
Follicular fluid and plasma lipidome profiling and associations towards embryonic development outcomes during ART treatment
Authors: Jiang Yingxin Celia , Che Qi , Lu Xinmei , Liu Miao , Ye Yao , Cao Xiang , Li Xushuo , Zhan Yanxia , Dong Xi , Cheng Yunfeng , O’Neill Christopher 
Published: December 2024

IntroductionIt is well acknowledged that lipids assume a critical role in oocyte maturation and early embryonic metabolism, this study aimed to evaluate the relationship between the lipid composition of plasma and follicular fluid (FF), and the consequences of embryonic development. This study compared the lipidomic profiles of paired plasma and FF samples obtained from sixty-five Chinese women who underwent assisted reproductive technology (ART) treatments.MethodsNon-targeted lipidomics analysis.ResultResults not only indicated similarities in lipid composition between these biofluids, but also revealed a number of unique differences. The biomatrix distinction was found to be primarily driven by lipids belonging to the lysophosphatidylcholines (LPC), phosphatidylethanolamines (PE), ether PE, and triglyceride (TG) classes. In addition, specific species from these subclasses were discovered to be correlated with embryo development outcomes during ART. Notably, the composition of the fatty acyl chains appeared to play a crucial role in these associations. Furthermore, thirteen plasma lipid variables were identified, represented by Phosphatidylcholine 18:014:0 and PE P-18:020:1, which correlated with successful blastocyst formation (BF).DiscussionThe present study demonstrated that FF has a distinctive lipid composition, setting it apart from plasma; and the association observed with embryonic development underscored an important role of lipid composition in the healthy development of oocytes.
Growth, Development and Reproduction of Meadow Moth Loxostege sticticalis Fed on Pea Seedlings Grown Under Elevated CO2
Authors: Zhou Jingxian , Xu Zun , Yu Zuoheng , Mai Huirong , Huang Jiacheng , Chang Xiaoli , Chen Fajun 
Published: December 2024

To comprehensively investigate the impacts of increased atmospheric CO2 concentrations on the growth, development and reproduction of the meadow moth Loxostege sticticalis when fed on pea plants (Pisum sativum), in this experiment, we simulated the two CO2 conditions: ambient CO2 (i.e., 400 μL/L designated as aCO2) and elevated CO2 (i.e., 800 μL/L designated as eCO2) by using light-CO2 climate chambers. Subsequently, the changes in several key nutrients and defensive compounds present in pea seedlings were assessed. Moreover, we assessed the growth, development, reproduction and changes in the nutritional components and enzyme activities of L. sticticalis as they fed on pea seedlings grown under aCO2 and eCO2. The results showed that the CO2 level significantly affected the measured indexes of pea seedlings and L. sticticalis. Host pea seedlings grown under eCO2 exhibited significant increases in soluble sugar (SS), soluble protein (SP) and total amino acid (TAA) contents by 42.52%, 77.06% and 62.50%, respectively, relative to those grown under aCO2. In addition, total phenol (TP), ethylene (ET) and jasmonic acid (JA) contents grown under eCO2 increased significantly by 20.60%, 71.72% and 36.22%, respectively, under eCO2 compared to aCO2. Furthermore, the duration of egg, larva and pupa of L. sticticalis was significantly shortened by 16.63%, 10.66% and 10.12%, respectively, while the adult longevity was significantly prolonged by 19.07% after feeding on pea seedlings grown under eCO2 in contrast to aCO2. Furthermore, for L. sticticalis, the content of SS, SP, TAA and free fatty acid was significantly increased, by 60.02%, 77.06%, 91.67% and 27.19%, respectively. Moreover, the enzyme activity of CAT, POD, CarE and GST was also enhanced by 56.70%, 63.89%, 128.08% and 93.45%, respectively, as they fed on pea seedlings grown under eCO2 in contrast to aCO2. The findings of our study revealed that eCO2 not only improved the nutritional quality but also altered the defensive compounds in the seedlings, which in turn affected the growth, development, reproduction and changes in the physiology of L. sticticalis.
Determination of Stable Reference Genes for Gene Expression Analysis in Black Rockfish (Sebastes schlegeli) Under Hypoxia Stress
Authors: Chen Xiatian , Yu Yujie , Gao Tao , Liu Zhifei , Chen Shuaiyu , Jia Yudong 
Published: December 2024

Background: Hypoxia triggers stress, leading to significant alterations in gene expression patterns, which in turn affect fish’s growth and development. Real-time quantitative PCR (RT-qPCR) is a pivotal technique for assessing changes in gene expression. However, its accuracy is highly contingent upon the stable expression of reference genes. Ribosomal RNA (18s), β-actin (actb), elongation factor 1-α (ef1a), α tubulin (tuba), and ribosomal protein L17 (rpl17) are the widely used reference genes, but their expression stability in the tissues of black rockfish under hypoxic conditions remains unclear. Methods: The expression of genes was detected by RT-qPCR and the stability was assessed by Delta Ct, geNorm, NormFinder, and BestKeeper algorithms. Results: Results showed that tuba exhibited stable expression in liver, heart, gill tissues under normoxic conditions, and in the liver and head kidney under hypoxic conditions. Ef1a was identified as the most stably expressed gene in gill tissue under hypoxia. For hypoxic heart studies, rpl17 and tuba were recommended as reference genes. 18s showed high stability in spleen tissue under hypoxic conditions. Actb was the most stably expressed gene in spleen and head kidney tissues under normoxic conditions. Conclusions: The identified reference genes exhibited tissue-specific stability, and it was necessary to select appropriate reference genes based on the specific tissue type for gene expression studies under hypoxic conditions. These findings help in enhancing the accuracy of gene expression analysis in the mechanism of hypoxia for black rockfish.
A SEMIOTIC ANALYSIS IN WARDAH COSMETIC ADVERTISEMENT STRATEGY
Authors: Riska Alvira , Adha Ruly , Suheri Dedy 
Published: December 2024

Wardah Cosmetics, a leading halal cosmetics brand in Indonesia, has captivated audiences through its advertisements that extend beyond product promotion to convey a complex network of meanings and symbols. This study delves into the semiotic usage of color within Wardah's advertisements, exploring how color choices contribute to brand identity, resonate with Muslim consumers, and reflect Islamic values. Employing a descriptive qualitative approach, this study analyzes a selected Wardah advertisement using Barthes' semiotic theory. The advertisement is examined to identify prominent visual symbols, particularly color choices, and their associated meanings. The analysis considers the relationship between the visual form (signifier) and the meaning it conveys (signified). The analysis revealed a strategic use of color that aligns with Wardah's brand identity and resonates with its Muslim target audience. Green symbolizes nature, life, and Islamic values, while blue evokes calmness, trust, and professionalism. These colors create a harmonious and appealing visual environment. Additionally, the use of white signifies purity and simplicity, while yellow represents cheerfulness, optimism, and energy. The semiotic analysis of Wardah's advertisement demonstrates the brand's effective use of color to convey a cohesive message that resonates with its target audience. The color choices not only enhance the visual appeal but also reinforce the brand's commitment to Islamic values and its positioning as a choice for modern Muslim women. This study contributes to the understanding of semiotic applications in advertising analysis, particularly within the context of cosmetic advertisements in Indonesia.

Keywords: Islamic marketing, color symbolism, cosmetic advertising, semiotics, Wardah Cosmetics
الحماية القانونية للبيانات ذات الطابع الشخصي للمستهلك في إطار معاملاته المصرفية الرقمية
Authors: عواطف زرارة  , بن حملة سامي  
Published: December 2024

شكّل موضوع الحماية القانونية للبيانات ذات الطابع الشخصي للمستهلك في إطار معاملاته المصرفية الرقمية موضوعا في غاية الأهمية بالنظر إلى التحول الرقمي الذي عرفته الحياة المصرفية الحديثة والتي أفرزت نمطا جديدا للتعاقد تمثل في المعاملات المصرفية الرقمية، وهذا ما شكّل تحدّ جديد بالنسبة للتشريعات المصرفية وكذلك تشريعات حماية المستهلك، فضلا عن تشريعات حماية البيانات الشخصية للمستهلك. تحاول هذه الدراسة بيان مدى إقرار التشريعات المصرفية الحديثة على غرار المشرع الاماراتي لحماية قانونية فعّالة للبيانات ذات الطابع الشخصي للمستهلك تعزيزا لمركزه القانوني وحماية لخصوصيته في إطار تعاملاته المصرفية الرقمية، بما يخدم تطور هذه المعاملات وحماية المستهلك.
وبالنظر لإخضاع المشرع الاماراتي حماية البيانات ذات الطابع الشخصي للمستهلك في إطار معاملاته المصرفية الرقمية للتشريعات المصرفية باعتبارها أحكاما خاصة، تعالج هذه الدراسة أسباب انتهاج المشرع الاماراتي لهذا المسلك ومُبررات ذلك في ظل وجود الأحكام المتعلقة بحماية البيانات الشخصية .
وتتناول هذه الدراسة نطاق حماية البيانات ذات الطابع الشخصي للمستهلك في إطار معاملاته المصرفية الرقمية وضوابط استخدامها من جهة، ومن جهة أخرى بيان حقوق المستهلك في مجال استخدام بياناته المصرفية والقيود والإنتهاكات المقترنة بها.
الحماية المدنية للمستهلك من الإعلانات التجارية المضللة لخدمات الإنترنت في ضوء القواعد الخاصة المستحدثة
Authors: عبد الله سعيد الكتبي  , محمود ابراهيم محمود فياض  
Published: December 2024

تبحث هذه الدراسة في تقييم دور القواعد الخاصة الصادرة حديثا عن المشرع الاماراتي في العام2023 في سد النقص الوارد في القواعد العامة، ذات العلاقة بالتعامل مع الإعلانات التجارية المضللة لخدمات الإنترنت. استخدمت الدراسة نماذج عن تلك الإعلانات التجارية، وعرضت عناصرها وصورها، تم انتقلت للبحث في مدى كفاية القواعد العامة والخاصة الواردة تشريعات دولة الامارات العربية المتحدة في حماية المستهلك من هذه الإعلانات المضللة. بحثت الدراسة بداية في ماهية عقود خدمات الإنترنت وخصائصها، ثم انتقلت بالحديث عن عناصر وصور التضليل في الإعلانات التجارية المتعلقة بخدمات الانترنت، وتقييم القواعد العامة والخاصة في التغلب عليها. خلص البحث الي نجاح القواعد الخاصة الواردة في قانون حماية المستهلك والأنظمة الصادرة عن الجهات الحكومية ذات العلاقة في سد النقص الوارد في القواعد العامة بما يحقق الأهداف المرجوة منها. خلص البحث إلى نجاح هذه القواعد الخاصة في الحد من انتشار هذه الإعلانات إما من خلال وجوب الموافقة الإجبارية المسبقة لهيئة تنظيم الاتصالات والحكومة الرقمية الإماراتية لأي إعلان تجاري قبل عرضه في السوق، مرورا بوجوب توافر مواصفات معينة في هذا الإعلان وحظر استخدام عبارات معينة، وانتهاء بسحل الإعلان التجاري الذي لا يراعي هذه الشروط وفرض جزاءات مالية على مروج هذا الإعلان.
Silicon oxide etching mechanism by hydrogen fluoride and methanol vapor mixture
Authors: Ohtake Hiroto , Hattori Takashi , Yamada Masaki 
Published: December 2024

Abstract
We investigate mechanisms of silicon dioxide (SiO2) etching involving hydrogen fluoride (HF) and a methanol (CH3OH) vapor mixture, particularly, the contributions of water (H2O) and CH3OH. H2O might come from the injected gases, chamber wall, and the SiO2 films, but the amount is very small. Instead, during the etching process, two molecules of H2O are generated, which might affect SiO2 etching. Considering no incubation time and stable etching rates by adding CH3OH, CH3OH could be a primary catalyst according to our investigations. Accordingly, we can suggest a SiO2 etching mechanism by HF and CH3OH. The mixture gases of HF and CH3OH are exposed to the SiO2 surface. When the HF and CH3OH pressures are high enough for condensation on the SiO2 surface, a thin condensed layer is generated. Hydrogen fluoride can be easily soluble to the condensed layer, at which it is ionized causing the etching of SiO2. A high enough concentration of byproducts generates vapor silicon terafluoride and H2O, enabling etching to proceed.
Miomectomia uterina: avanços nos procedimentos envolvendo cirurgia robótica
Authors: Pereira de Souza Florentino Janaína , Souza Dias Emanuele , Feuser Furtuoso Heloisa , Souza Rozendo Thairone , Lopes do Vale Janaina , De Melo Correia Gustavo José , Schultz Zago Maria Rita , Escarpini Peruzin Pedro Igor , Comper José Rafael , Alves do Carmo Nayara , Dela Corte de Paula Ferreira Gabriel , Bunjes Moussallem Lara , Bernardes da Silva Dantas Eduarda , De Oliveira Silva Rafael Antonio , Cordeiro Rodrigues João Pedro , Manhães Moreira Matheus , Cavalcante Silva Allyka , Trevisan Magri Beatriz 
Published: December 2024

O mioma uterino, também conhecido como fibroma uterino ou leiomioma, é o tumor benigno mais comum do trato reprodutivo feminino. A miomectomia uterina é o procedimento cirúrgico indicado para a remoção de miomas uterinos, visando preservar o útero e a fertilidade da paciente. É considerada uma alternativa terapêutica frente a miomas sintomáticos que não respondem a tratamentos clínicos, como medicamentos hormonais. A importância deste artigo reside em seu potencial para contribuir com a atualização e ampliação do conhecimento sobre os avanços nas técnicas cirúrgicas para o tratamento de miomas uterinos. Dada a alta prevalência de miomas entre as mulheres em idade fértil e os desafios relacionados ao tratamento conservador e cirúrgico dessa condição, a compreensão dos benefícios da cirurgia robótica pode auxiliar médicos e profissionais da saúde na escolha do tratamento mais adequado. Trata-se de uma revisão sistemática da literatura, a qual investigou sobre a abordagem robótica da miomectomia uterina, pela coleta de dados nas plataformas PubMed, LILACS, Periódicos CAPES, EMBASE e Scielo. Assim, a análise dos estudos revisados revela que a miomectomia robótica tem se consolidado como uma abordagem eficaz e segura no tratamento de miomas uterinos, com vantagens notáveis, especialmente em termos de redução da perda sanguínea, menor taxa de conversão e maior precisão operatória, em comparação com as técnicas laparoscópica e abdominal. Embora os tempos operatórios tendam a ser mais longos em procedimentos robóticos, esses métodos demonstram resultados similares às abordagens laparoscópicas em termos de taxas de complicações, taxas de gravidez e dores pós-operatórias, com a robótica proporcionando melhor exposição cirúrgica e destreza. Em comparação com a miomectomia abdominal, a robótica apresenta menores taxas de transfusão sanguínea e complicações, além de proporcionar uma
PHYSICOCHEMICAL AND SENSORY PROPERTIES OF FERMENTED PROSOPIS AFRICANA SEEDS
Authors: Sikiru Musbau , R.A Asiru 
Published: December 2024

Background: Fermented Prosopis Africana seeds called Okpehe by the Idoma people of Benue State, Nigeria are a commonly prepared food Condiment added to food so as to improve its aroma and taste
Methods: It was produced in the laboratory using Spontaneous method and preserved for twelve days using different concentration of Clove and Ginger extracts (1.6%, 2.4%, and 3.2%). The aim of the study was to evaluate physicochemical and sensory parameters of fermented Prosopis Africana seeds during preservation.
Results: A total of 100 responses were obtained, out of which 50% of respondents opted for offline purchase of medicines from nearby pharmacies. In conclusion, it was observed that the majority of the population prefers the offline mode of purchase when it comes to the purchase of medicines and other healthcare products, though there are various major advancements in technology and variety of internet services and easy availability of e-medicines.
Conclusion: It can be inferred from this study that the extracts of spices represent an alternative source of natural antimicrobial substances for use in food systems to prevent the growth of food borne microorganisms and extend the shelf-life of the processed food.
The PENDAMPINGAN DAN PENGEMBANGAN DIGITALISASI UMKM ANEKA KERIPIK SINGKONG PUTRI SARI DESA WONOKERTO, KABUPATEN JOMBANG
Authors: Febrianti Dina Ayu , Vitasari Dilla Nur , Simbolon Ella Stevani , Roidah Ida Syamsu 
Published: December 2024

Jumlah panen singkong yang meningkat telah mendorong Putri Sari untuk melihat peluang usaha dengan membentuk UMKM yang memproduksi keripik singkong. Namun, dalam upaya pemasarannya, UMKM ini masih menghadapi kendala besar karena pemasarannya yang masih sangat minim dan terbatas. Oleh karena itu, diperlukan penerapan digitalisasi untuk mengatasi masalah ini. Penerapan teknologi digital juga dapat membantu dalam mengoptimalkan proses produksi dan distribusi, sehingga UMKM dapat beroperasi dengan lebih efisien dan responsif terhadap kebutuhan konsumen. Kegiatan ini membantu UMKM singkong Putri Sari dalam pembuatan logo dan pendampingan dalam pembuatan e-commerce yaitu akun shopee. Metode yang digunakan yaitu Service Learning. Program ini dilakukan melalui 3 tahapan yaitu perencanaan, pelaksanaan dan evaluasi. Sehingga di harapkan melalui pembuatan logo dan akun shopee penjualan keripik singkong Putri Sari dapat meningkat serta lebih berkembang.