bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort profile: the Women’s Health Accelerometry Collaboration
Authors: Evenson Kelly R , Bellettiere John , Cuthbertson Carmen C , Di Chongzhi , Dushkes Rimma , Howard Annie Green , Parada Jr. Humberto , Schumacher Benjamin T , Shiroma Eric J , Wang Guangxing , Lee I-Min , LaCroix Andrea Z 
Published: November 2021

PurposeThis paper describes the Women’s Health Accelerometry Collaboration, a consortium of two prospective cohort studies of women age 62 years or older, harmonised to explore the association of accelerometer-assessed physical activity and sedentary behaviour with cancer incidence and mortality.ParticipantsA total of 23 443 women (age mean 73.4, SD 6.8) living in the USA and participating in an observational study were included; 17 061 from the Women’s Health Study (WHS) and 6382 from the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health (WHI/OPACH) Study.Findings to dateAccelerometry, cancer outcomes and covariate harmonisation was conducted to align the two cohort studies. Physical activity and sedentary behaviour were measured using similar procedures with an ActiGraph GT3X+ accelerometer, worn at the hip for 1 week, during 2011–2014 for WHS and 2012–2014 for WHI/OPACH. Cancer outcomes were ascertained via ongoing surveillance using physician adjudicated cancer diagnosis. Relevant covariates were measured using questionnaire or physical assessments. Among 23 443 women who wore the accelerometer for at least 10 hours on a single day, 22 868 women wore the accelerometer at least 10 hours/day on ≥4 of 7 days. The analytical sample (n=22 852) averaged 4976 (SD 2669) steps/day and engaged in an average of 80.8 (SD 46.5) min/day of moderate-to-vigorous, 105.5 (SD 33.3) min/day of light high and 182.1 (SD 46.1) min/day of light low physical activity. A mean of 8.7 (SD 1.7) hours/day were spent in sedentary behaviour. Overall, 11.8% of the cohort had a cancer diagnosis (other than non-melanoma skin cancer) at the time of accelerometry measurement. During an average of 5.9 (SD 1.6) years of follow-up, 1378 cancer events among which 414 were fatal have occurred.Future plansUsing the harmonised cohort, we will access ongoing cancer surveillance to quantify the associations of physical activity and sedentary behaviour with cancer incidence and mortality.
Characteristics of low-acuity paediatric emergency department consultations in two tertiary hospitals in Switzerland: a retrospective observational study
Authors: Jaboyedoff Manon , Starvaggi Carl , Suris Joan-Carles , Kuehni Claudia E , Gehri Mario , Keitel Kristina , Pellaton Rachel 
Published: November 2021

BackgroundLow-acuity paediatric emergency department (PED) visits are common in high-income countries and are an increasing burden for the healthcare system and quality of care. Little is known about low-acuity PED visits in Switzerland. This study shows frequency and characteristics of such visits in two large PEDs in German-speaking and French-speaking regions of Switzerland.MethodsWe conducted a retrospective observational study in the PED of two Swiss tertiary care hospitals, Bern and Lausanne. We extracted standardised administrative and medical data from the clinic information system for all PED visits of children aged 0–17 years from January to December 2018. We defined low-acuity visits as those meeting all of the following criteria: (1) triage category 4 or 5 on the Australasian Triage Scale, (2) no imaging or laboratory test performed and (3) discharge home. We used a binary multiple logistic regression model to identify factors associated with low-acuity visits.ResultsWe analysed 53 089 PED visits. The proportion of low-acuity visits was 54% (95% CI 53% to 54%, 28 556 visits). Low-acuity visits were associated with age younger than 5 years (adjusted OR, aOR 1.87, 95% CI 1.81 to 1.94), living within a 5 km radius of PED (aOR 1.27, 95% CI 1.22 to 1.32), and after hour presentations (weekends: aOR 1.14, 95% CI 1.10 to 1.18, nights: aOR 1.10, 95% CI 1.23 to 1.36).ConclusionLow-acuity visits are frequent in our PEDs and associated with younger age and convenience factors (proximity of residency and after hour presentation), pointing to a high demand for paediatric urgent care services in Switzerland not currently covered by the primary healthcare system.
Immune checkpoint blocking impact and nomogram prediction of COVID-19 inactivated vaccine seroconversion in patients with cancer: a propensity-score matched analysis
Authors: Ma Yifei , Liu Nianqi , Wang Youlong , Zeng Jiling , Hu Ying-Ying , Hao Wu , Shi Huazheng , Zhu Pengfei , Lv Jun , Fan Wei , Wang Xinjia 
Published: November 2021

BackgroundPatients with cancer on active immune checkpoint inhibitors therapy were recommended to seek prophylaxis from COVID-19 by vaccination. There have been few reports to date to discuss the impact of progression cell death-1 blockers (PD-1B) on immune or vaccine-related outcomes, and what risk factors that contribute to the serological status remains to be elucidated. The study aims to find the impact of PD-1B on vaccination outcome and investigate other potential risk factors associated with the risk of seroconversion failure.MethodsPatients with active cancer treatment were retrospectively enrolled to investigate the interaction effects between PD-1B and vaccination. Through propensity score matching of demographic and clinical features, the seroconversion rates and immune/vaccination-related adverse events (irAE and vrAE) were compared in a head-to-head manner. Then, a nomogram predicting the failure risk was developed with variables significant in multivariate regression analysis and validated in an independent cohort.ResultsPatients (n=454) receiving either PD-1B or COVID-19 vaccination, or both, were matched into three cohorts (vac+/PD-1B+, vac+/PD-1B-, and vac-/PD-1B+, respectively), with a non-concer control group of 206 participants. 68.1% (94/138), 71.3% (117/164), and 80.5% (166/206) were seropositive in vac+/PD-1B+cohort, vac+/PD-1B- cohort, and non-cancer control group, respectively. None of irAE or vrAE was observed to be escalated in PD-1B treatment except for low-grade rash.The vaccinated patients with cancer had a significantly lower rate of seroconversion rates than healthy control. A nomogram was thus built that encompassed age, pathology, and chemotherapy status to predict the seroconversion failure risk, which was validated in an independent cancer cohort of 196 patients.ConclusionAlthough patients with cancer had a generally decreased rate of seroconversion as compared with the healthy population, the COVID-19 vaccine was generally well tolerated, and seroconversion was not affected in patients receiving PD-1B. A nomogram predicting failure risk was developed, including age, chemotherapy status, pathology types, and rheumatic comorbidity.
Adsorption of helium on a charged propeller molecule: hexaphenylbenzene
Authors: Kollotzek Siegfried , Calvo Florent , Krasnokutski Serge , Zappa Fabio , Scheier Paul , Echt Olof 
Published: November 2021

Abstract
Physisorption on planar or curved graphitic surfaces or aromatic rings has been investigated by various research groups, but in these studies, the substrate was usually strictly rigid. Here, we report a combined experimental and theoretical study of helium adsorption on cationic hexaphenylbenzene (HPB), a propeller-shaped molecule. The orientation of its propeller blades is known to be sensitive to the environment, with substantial differences between the molecule in the gas phase and in the crystalline solid. Mass spectra of He$$_{n}$$

n

HPB$$^{+}$$

+

, synthesized in helium nanodroplets, indicate enhanced stability for ions containing $$n = 2, 4, 14, 28, 42, 44$$

n
=
2
,
4
,
14
,
28
,
42
,
44

, or 46 helium atoms. Path-integral molecular dynamics simulations reveal a significant dependence of the dissociation energy on the details of the HPB geometry. Good agreement between the experimental data and calculated dissociation energies is obtained, provided that the symmetry of HPB$$^{+}$$

+

is reduced from $$D_{6}$$

D
6

to $$D_{2}$$

D
2

, such a lower symmetry being suggested from quantum chemical calculations as arising upon electron removal.

Graphic Abstract
New species of fermions and bosons, cosmological constant problem and a farewell to spin–statistics theorem
Authors: Ahluwalia Dharam Vir 
Published: November 2021

If dark matter exists in the form of ultralight fermionic and bosonic species, then (a) it can accelerate evaporation of astrophysical black holes to the extent that their lifetimes can be reduced to astronomical time scales, a and (b) if there are extremely large number of such species it has the potential to solve the hierarchy problem [H. Davoudiasl, P. B. Denton and D. A. McGady, Phys. Rev. D 103 (2021) 055014; G. Dvali, Fortschr. Phys. 58 (2010) 528]. Here, we put forward a proposal that darkness of many of these new particles is natural, and in addition, the net zero point energy of the fermions exactly cancels that coming from the new bosons. The needed fermion–boson equality, and matching the fermion–boson degrees of freedom, comes about naturally. A very direct argument that allows the departure from the spin–statistics theorem is presented. a This happens in two steps: first, the relatively rapid evaporation of the ultralight particles, and the second slower one associated with a hundred or so ‘heavier’ particles of the standard model.
Computer-aided diagnosis of retinopathy based on vision transformer
Authors: Jiang Zhencun , Wang Lingyang , Wu Qixin , Shao Yilei , Shen Meixiao , Jiang Wenping , Dai Cuixia 
Published: November 2021

Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME) are two common retinal diseases for elder people that may ultimately cause irreversible blindness. Timely and accurate diagnosis is essential for the treatment of these diseases. In recent years, computer-aided diagnosis (CAD) has been deeply investigated and effectively used for rapid and early diagnosis. In this paper, we proposed a method of CAD using vision transformer to analyze optical coherence tomography (OCT) images and to automatically discriminate AMD, DME, and normal eyes. A classification accuracy of 99.69% was achieved. After the model pruning, the recognition time reached 0.010 s and the classification accuracy did not drop. Compared with the Convolutional Neural Network (CNN) image classification models (VGG16, Resnet50, Densenet121, and EfficientNet), vision transformer after pruning exhibited better recognition ability. Results show that vision transformer is an improved alternative to diagnose retinal diseases more accurately.
Classi-Fly: Inferring Aircraft Categories from Open Data
Authors: Strohmeier Martin , Smith Matthew , Lenders Vincent , Martinovic Ivan 
Published: November 2021

In recent years, air traffic communication data has become easy to access, enabling novel research in many fields. Exploiting this new data source, a wide range of applications have emerged, from weather forecasting to stock market prediction, or the collection of intelligence about military and government movements. Typically, these applications require knowledge about the metadata of the aircraft, specifically its operator and the aircraft category.armasuisse Science + Technology, the R&D agency for the Swiss Armed Forces, has been developing Classi-Fly, a novel approach to obtain metadata about aircraft based on their movement patterns. We validate Classi-Fly using several hundred thousand flights collected through open source means, in conjunction with ground truth from publicly available aircraft registries containing more than 2 million aircraft. We show that we can obtain the correct aircraft category with an accuracy of greater than 88%. In cases, where no metadata is available, this approach can be used to create the data necessary for applications working with air traffic communication. Finally, we show that it is feasible to automatically detect particular sensitive aircraft such as police and surveillance aircraft using this method.
A Phase 1a/b Open-Label, Dose-Escalation Study of Etigilimab Alone or in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors
Authors: Mettu Niharika B. , Ulahannan Susanna V. , Bendell Johanna C. , Garrido-Laguna Ignacio , Strickler John H. , Moore Kathleen N. , Stagg Robert , Kapoun Ann M. , Faoro Leonardo , Sharma Sunil 
Published: November 2021

AbstractPurpose:TIGIT (T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain) is a co-inhibitory receptor of T-cell and natural killer cell activity. Targeting TIGIT with or without PD-1/PD-L1 checkpoint inhibition may enhance antitumor immunity.Patients and Methods:This Phase 1a/b trial was a first-in-human, open-label, multicenter, dose-escalation and -expansion study in patients with locally advanced or metastatic solid tumors. Using 3 + 3 design, patients underwent 14-day treatment cycles with anti-TIGIT antibody etigilimab alone (Phase 1a; 0.3, 1.0, 3.0, 10.0, 20.0 mg/kg intravenously) or in combination with anti–PD-1 antibody nivolumab (Phase 1b; 3.0, 10.0, 20.0 mg/kg etigilimab and 240 mg nivolumab). Primary objective was safety and tolerability.Results:Thirty-three patients were enrolled (Phase 1a, n = 23; Phase 1b, n = 10). There were no dose-limiting toxicities (DLT). MTD for single and combination therapy was not determined; maximum administered dose was 20 mg/kg. The most commonly reported adverse events (AE) were rash (43.5%), nausea (34.8%), and fatigue (30.4%) in Phase 1a and decreased appetite (50.0%), nausea (50.0%), and rash (40%) in Phase 1b. Six patients experienced Grade ≥3 treatment-related AEs. In Phase 1a, 7 patients (30.0%) had stable disease. In Phase 1b, 1 patient had a partial response; 1 patient had prolonged stable disease of nearly 8 months. Median progression-free survival was 56.0 days (Phase 1a) and 57.5 days (Phase 1b). Biomarker correlative analyses demonstrated evidence of clear dose-dependent target engagement by etigilimab.Conclusions:Etigilimab had an acceptable safety profile with preliminary evidence of clinical benefit alone and in combination with nivolumab and warrants further investigation in clinical trials.
A Randomized Trial of Fulvestrant, Everolimus, and Anastrozole for the Front-line Treatment of Patients with Advanced Hormone Receptor–positive Breast Cancer, SWOG S1222
Authors: Moore Halle C.F. , Barlow William E. , Somlo George , Gralow Julie R. , Schott Anne F. , Hayes Daniel F. , Kuhn Peter , Hicks James B. , Welter Lisa , Dy Philip A. , Yeon Christina H. , Conlin Alison K. , Balcueva Ernie , Lew Danika L. , Tripathy Debasish , Pusztai Lajos , Hortobagyi Gabriel N. 
Published: November 2021

Abstract

Purpose:
Metastatic hormone receptor (HR)-positive, HER2-negative breast cancer is an important cause of cancer mortality. Endocrine treatment with or without additional targeted therapies has been the mainstay of treatment. This trial was designed to evaluate the combination of fulvestrant plus everolimus versus fulvestrant, everolimus, and anastrozole compared with fulvestrant alone in the first-line treatment of advanced HR-positive, HER2-negative breast cancer.

Patients and Methods:
This randomized placebo-controlled trial included postmenopausal women with HR-positive, HER2-negative advanced breast cancer who had received no prior systemic therapy for metastatic disease. Participants were randomized to one of three treatment arms and the primary outcome was progression-free survival (PFS), comparing combinations of fulvestrant and everolimus with or without anastrozole with fulvestrant alone. Circulating tumor cells (CTC), as measured with two different methods, and circulating tumor DNA (ctDNA) were evaluated serially prior to treatment and the beginning of the second cycle of therapy.

Results:
Due in part to changes in clinical practice, the study was closed after accruing only 37 participants. There was no evidence that everolimus-containing combination treatment improved PFS or overall survival relative to fulvestrant alone. When modeled continuously, an association was observed of baseline CTC and ctDNA with poorer survival.

Conclusions:
Although power of the study was limited, the findings were unable to support the routine use of everolimus combination endocrine therapy in the first-line treatment of advanced hormone-sensitive breast cancer. Prognostic impact of baseline ctDNA and copy-number variations in CTC was demonstrated.
Absurdo! A repetição na obra de Eva Hesse
Authors: Alcântara Luiza , Oliveira Rachel Cecília de 
Published: November 2021

Este artigo analisa a obra de Eva Hesse sem recair nos vícios que parte da crítica de arte e da historiografia reproduzem ao abordar obras de arte feitas por mulheres. Isso é feito mostrando como as obras de Eva Hesse corroboram uma ideia de gesto livre, do gesto como sua intencionalidade, uma forma de vestígio de corpo, de presença. Por meio dos conceitos de índice, repetição e gesto, traçamos diferenças entre a artista e seus contemporâneos, enfatizando os movimentos aos quais sua obra é tradicionalmente associada: o minimalismo e a arte conceitual.
Subject, Object, and Knowledge as First-Person
Authors: Antognazza Maria Rosa 
Published: November 2021

Abstract
This article tries to show that focusing on why and how subject and object are distinct is of key importance for understanding the nature of knowledge itself. It argues that: 1) cognition starts with an aliud which is present to a felt self in a way fundamentally different from one’s own modes of being; 2) individual human knowledge in its paradigmatic form is essentially first-personal, that is, its object-directedness requires a built-in, implicit awareness of a ‘self’ that provides the unifying perspective from which the aliud is apprehended; 3) this is a first-order awareness which is crucially distinct from the second-order awareness which requires a reflexive cognitive act – a distinction which the author proposes to cash out in terms of ‘first-person knowledge’ versus ‘self-knowledge.
Knowing, Knowing Perspicuously, and Knowing How One Knows
Authors: Longworth Guy 
Published: November 2021

Abstract
In Knowing and Seeing, Michael Ayers presents a view of what he calls primary knowledge according to which one who knows in that way both knows perspicuously and knows how they know. Here, I use some general considerations about seeing, knowing, and knowing how one knows in order to raise some questions about this view. More specifically, I consider some putative limits on one’s capacity to know how one knows. The main question I pursue concerns whether perspicuity should be thought of either (i) as a condition of sensory experience, (ii) as a condition of sense-based cognition, or (iii) as an interface condition, involving interrelations between sensory experience and sense-based cognition.
« Le mal ne s’enracine pas dans l’instauration ». La question du mal dans le shiʿisme ismaélien
Authors: De Smet Daniel 
Published: November 2021

Abstract
As is the case with other Shiʿi traditions, Ismailism developed a dualistic worldview ruled by the opposition between good and evil, light and darkness. However, it is a rather moderate form of dualism, as the principle of evil is not coexistent with the Creator or has not been created by Him. Evil only appears at a lower level of the cosmic hierarchy. This doctrine has been elaborated in four different ways in the history of Ismailism. We first meet a gnostic thesis where evil is the result of a rebellion in the intelligible world; second, there is a Neoplatonic thesis where evil and imperfection are caused by the process of emanation itself; and third, we distinguish a philosophical thesis where the generation of evil by “second intention” belongs to the rule of divine providence. Finally, Ṭayyibī authors in the 12th century made a synthesis of the three positions.
L’ismaélisme, à l’instar d’autres courants shiʿites, prône une vision dualiste du monde marquée par l’opposition éternelle entre le bien et le mal, la lumière et les ténèbres. Cependant, il s’agit d’un dualisme mitigé, où le mal n’est ni coexistant avec le Créateur, ni instauré par Lui, mais apparaît à un degré inférieur de la hiérarchie cosmique. Cette thèse a été développée de quatre manières différentes au cours de l’histoire doctrinale de l’ismaélisme. Nous distinguons successivement une thèse gnostique où le mal est le résultat d’une révolte dans le monde intelligible, une thèse néoplatonicienne où le mal et l’imperfection sont générés par le processus de l’émanation, et une thèse philosophique où le mal est causé par « seconde intention » par la Providence divine. Une synthèse de ces trois thèses a été élaborée dans le Ṭayyibisme à partir du 12e siècle.
Attribution of Dry and Wet Climatic Changes over Central Asia
Authors: Ren Yu , Yu Haipeng , Liu Chenxi , He Yongli , Huang Jianping , Zhang Lixia , Hu Huancui , Zhang Qiang , Chen Siyu , Liu Xiaoyue , Zhang Meng , Wei Yun , Yan Yaoxian , Fan Weiwei , Zhou Jie 
Published: November 2021

AbstractCentral Asia (CA; 35°–55°N, 55°–90°E) has been experiencing a significant warming trend during the past five decades, which has been accompanied by intensified local hydrological changes. Accurate identification of variations in hydroclimatic conditions and understanding the driving mechanisms are of great importance for water resource management. Here, we attempted to quantify dry/wet variations by using precipitation minus evapotranspiration (P − E) and attributed the variations based on the atmosphere and surface water balances. Our results indicated that the dry season became drier while the wet season became wetter in CA for 1982–2019. The land surface water budget revealed precipitation (96.84%) and vapor pressure deficit (2.26%) as the primary contributing factors for the wet season. For the dry season, precipitation (95.43%), net radiation (3.51%), and vapor pressure deficit (−2.64%) were dominant factors. From the perspective of the atmospheric water budget, net inflow moisture flux was enhanced by a rate of 72.85 kg m−1s−1in the wet season, which was mainly transported from midwestern Eurasia. The increase in precipitation induced by the external cycle was 11.93 mm (6 months)−1. In contrast, the drying trend during the dry season was measured by a decrease in the net inflow moisture flux (74.41 kg m−1s−1) and reduced external moisture from midwestern Eurasia. An increase in precipitation during the dry season can be attributed to an enhancement in local evapotranspiration, accompanied by a 4.69% increase in the recycling ratio. The compounding enhancements between wet and dry seasons ultimately contribute to an increasing frequency of both droughts and floods.