bluuebunny/crossref_metadata_2025_split huggingface dataset:
El arte de la palabra en el aula
Authors: Parra Mabel 
Published: August 2021

El objetivo de este trabajo es rescatar la retórica clásica y destacarsu importancia en el aula. Este arte de la palabra, que se remonta ala Grecia clásica, se constituye en discurso epistémico que busca la«verdad» con el fin de «enseñar». Los actuales estudios lingüísticos:la teoría de la enunciación, de los actos de habla, de la argumentación,del discurso desde una perspectiva crítica y muchos otros que se relacionancon la retórica, permiten considerar el discurso persuasivoque desarrolla estrategias argumentativas y establece relaciones entreenunciador/enunciatario/os.Desde esta perspectiva, la inclusión de la retórica en el aula es casiobligatoria e impostergable, porque el docente, con una adecuada preparación,puede generar las estrategias para canalizar e incentivar lapráctica retórica desde una perspectiva crítica.

ARK: http://id.caicyt.gov.ar/ark:/s22507132/jek0dva6q
Didáctica y juego en la educación superior: configuraciones en la formación docente inicial
Authors: Jorge Navarro Marcelo Gastón 
Published: August 2021

La didáctica no puede entenderse como un campo acabado de estudioque brinda recetas o fórmulas para enseñar, sino como un espacio dedebate y diálogo en constante construcción de nuevos conocimientos.Partiendo de esta idea reflexionamos sobre la importancia de la didácticay el juego en la formación docente de grado en la educación superiorcomo forma de trabajo que interpela a la interacción constanteentre docente y alumnos, y donde el papel de estos últimos es la principalfuente de construcción de aprendizajes individuales y colectivos.El objetivo del siguiente ensayo es presentar una variedad de perspectivaspara entender y analizar los procesos didácticos enfocados enaspectos lúdicos desde una visión crítica y reflexiva, que dé una miradaholística a la formación docente para así permitir nuevos debates yampliar el panorama de aplicación de diferentes estrategias y técnicasde enseñanza.

ARK: http://id.caicyt.gov.ar/ark:/s22507132/8n1sak4st
n. 32 - POLÍTICAS PÚBLICAS DA EDUCAÇÃO DE JOVENS E ADULTOS E DA EDUCAÇÃO ESPECIAL NO BRASIL: BREVE CONTEXTUALIZAÇÃO
Authors: Trentin Valéria Becher 
Published: August 2021

Este artigo traz uma abordagem da trajetória de escolarização de Jovens e Adultos com deficiência na educação brasileira, onde objetiva-se analisar historicamente a articulação entre as políticas públicas das modalidades de ensino EJA e Educação Especial. Assim, caracteriza-se por uma análise documental sobre o movimento das modalidades de ensino e as políticas públicas que as regem. Foram utilizadas fontes primárias e secundárias de pesquisa a qual abarca o período de 1990 até 2016. Mediante a breve análise constatou-se que a busca por soluções para o analfabetismo e para a inclusão caracteriza-se como um processo de tensões, conflitos e influências. Observou-se também a ausência de articulação entre as modalidades da EJA e a Educação Especial nas políticas públicas, o que aponta o longo caminho a ser percorrido para que jovens e adultos com deficiência tenham garantido efetivamente o direito a uma educação de qualidade.
Assessment of Clonotypic Rearrangements and Minimal Residual Disease in Lymphoid Malignancies
Authors: Hussaini Mohammad O. , Srivastava Jaya , Lee Lik Wee , Nishihori Taiga , Shah Bijal D. , Alsina Melissa , Pinilla-Ibarz Javier , Shain Kenneth H. 
Published: August 2021

Context.—
Measurable (minimal) residual disease (MRD) is an independent prognostic factor for survival outcomes in patients with lymphoid and plasma cell malignancies and has been incorporated into consensus criteria regarding treatment response, strategy, and clinical trial endpoints. clonoSEQ (a next-generation sequencing [NGS]-MRD assay) uses multiplex polymerase chain reaction and NGS to identify clonotypic rearrangements at the immunoglobulin (Ig) H, IgK, IgL, T-cell receptor (TCR)-β, and TCR-γ loci, as well as translocated B-cell lymphoma 1/IgH and 2/IgH sequences for MRD assessment. Additionally, it can be used to confirm diagnoses of cutaneous T-cell lymphoma (CTCL).

Objective.—
To review the technical aspects of our experience using the clonoSEQ Assay in routine clinical practice.

Design.—
In this single-center experience, 390 patients with lymphoid and plasma cell malignancies were assessed with the NGS-MRD Assay at a central laboratory.

Results.—
Median time from arrival of the shipment to initiation of the assay (defined as captured in Adaptive's secure tracking system) was 2.1 hours. Overall, 317 patients had 1 or more samples submitted for sequence identification. Of these, 290 (91.5%) had trackable sequences identified. The median calibration rate of samples by malignancy (where n ≥ 10 samples, excluding CTCL samples) was 88.1%, across a variety of fresh and archived sample sources (177 of 201 samples). TCR-β and/or TCR-γ clonotypes were identified in 40 of 95 samples (42.1%) from 66 patients with suspected CTCL.

Conclusions.—
This NGS-MRD Assay is a valuable and sensitive tool for monitoring MRD in patients with plasma cell and lymphoid malignancies and assisting in the diagnosis of CTCL.
En la lucha final, la arficiosa y fallida novela de Rafael Chirbes
Authors: Llamas Martínez Jacobo 
Published: August 2021

Rafael Chirbes se negó a reeditar su novela En la lucha finalpor considerarla fallida, y la editorial Anagrama ha respetado por ahora esa voluntad, de manera que únicamente se ha publicado una edición en 1991. En este artículo se estudian las razones literarias por las que el autor pudo haber tomado esta decisión; muchas de las cuales justifican las convicciones y la trayectoria posterior de Chirbes como escritor.
Rafael Chirbes refused to reissue his novel En la lucha final, considering it failed, and the publishing house Anagrama has so far respected that will. There was only one edition published in 1991. This article studies the literary reasons why the author may have made this decision. Many of them also explain Chirbes’s convictions and career as a writer.
Da etimologia à harmonização neo-latina: motivações gráficas na escritura de a mais encantadora mulher (1903) do romancista brasileiro Gonzaga Filho
Authors: Lima Hozanete 
Published: August 2021

Neste trabalho, refletimos sobre a natureza das motivações defendidas pelo romancista brasileiro Gonzaga Filho em sua obra “A Mais Encantadora Mulher”, publicada em 1903. Além das proposições etimológicas, fonéticas e prosódicas, o autor faz uso de uma proposição muito particular, que ele nomeia de harmonia neo-natina. Para o autor, não havia, até a data de publicação de seu romance, no mundo lusófono, nenhum léxico que se impusesse como autoridade a ser seguida. Através da obra de Gonzaga Filho, observamos o comportamento do movimento metaortográfico que se desvelou, no início do século XX, para a constituição ortográfica da língua portuguesa em sincronias passadas e sua importância no processo de estandardização da grafia.
In this work, we reflect on the nature of the motivations defended by the Brazilian novelist Gonzaga Filho in his work “A Mais Encantadora Mulher”, published in 1903. In addition to the etymological, phonetic and prosodic propositions, the author makes use of a very particular proposition, which he names neo-natin harmonization. For the author, there was not, until the date of publication of his novel, in the Portuguese-speaking world, no single lexicon that would impose itself as an authority to be followed. Through the work of Gonzaga Filho, we observe the behavior of the metaorthographic movement that was unveiled, at the beginning of the 20th century, for the orthographic constitution of the Portuguese language in past synchronisms and its importance in the standardization process of spelling
viaje narrativo y el libro de viaje medievales
Authors: Carmona Fernández Fernando 
Published: August 2021

El artículo señala la importancia del viaje en el relato literario medieval que responde al despertar sociocultural del siglo xii y caracteriza la llamada novela realista de los siglos xiii y xiv. En particular, al Escoufle de Jehan Renart, a la Manekine de Philippe de Remy y al Roman du comte d’Anjou de Jean Maillart. Novelas coetáneas a la expansión de los libros de viaje y ligadas a estos en la concepción del viaje.
This article points out the importance of travel books in the medieval literary story that responds to the sociocultural awakening of the 12th century and characterizes the realist novel of the 13th and 14th centuries. Particularly noteworthy are Jehan Renart's Escoufle, Philippe de Beaumanoir's Manekine and Jean Maillart's Roman du comte d'Anjou. These novels are contemporary to the expansion of travel books and are connected to the concept of travel.
intensificación en controversias en líneas en español
Authors: Aulit Laetitia 
Published: August 2021

Esta investigación presenta un análisis de la intensificación en un corpus de comentarios en español a artículos de prensa digitales sobre la fiesta de Moros y Cristianos, una tradición controvertida en España por el tratamiento de ciertos grupos sociales. Basándose en Albelda y Briz (2020), definimos la intensificación como una estrategia retórico-pragmática de argumentación por la que el hablante refuerza lo dicho y/o su intención para lograr más eficazmente sus metas conversacionales en el discurso. Por eso, este artículo se interesa por las estrategias lingüísticas de intensificación empleadas para posicionarse en estas controversias, tomando en cuenta los contextos comunicativos en los que aparecen, así como las funciones que desempeñan respecto a la argumentación y la imagen. A partir de una metodología adaptada de la metodología desarrollada por Albelda et al. (2014), los resultados muestran que la intensificación aparece principalmente en intervenciones que reaccionan a lo dicho anteriormente de forma general para reforzar la expresión de la postura personal del hablante.
This article presents an analysis of intensification in a corpus of comments in Spanish to digital press articles about the Moors and Christians festival, a tradition that led to controversies in Spain due to its treatment of certain social groups. Based on Albelda and Briz (2020), intensification is defined as a rhetorical and pragmatic strategy of argumentation whereby the speaker strengthens what he says and/or his intention to achieve more efficiently his conversational goals. Therefore, this paper looks into the linguistic strategies of intensification, taking into consideration the specific interactional contexts in which they appear and the functions they carry out regarding argumentation and face. Based on the methodology developed by Albelda and al. (2014), the results show that intensification appears mainly in moves that respond to the entire discussion in order to strengthen the expression of the personal perspective of the speaker.
arte entremesil de Jerónimo de Cáncer y Velasco
Authors: González Maya Juan Carlos 
Published: August 2021

Don Jerónimo de Cáncer y Velasco, comediante de la primera mitad del siglo xvii, es uno de esos ingenios que en las monografías, antologías o tratados de teatro breve siempre se destaca por sus habilidades, pero, en cambio, ha sufrido escasa fortuna en las prensas modernas. Motivo por el cual nos ha llegado solo parcial e insuficientemente editado. En el presente artículo se intenta, precisamente por ello, un acercamiento a su arte entremesil a través de una mirada crítica a sus piezas más recónditas o inéditas en honor a sus merecimientos, a partir de la publicación de la primera antología de su teatro breve.
Jerónimo de Cáncer y Velasco, a comedian from the first half of the seventeenth century, is one those witty geniuses that in monographs, anthologies or short theatrical treatises shine for their abilities, though on the contrary he has had little fortune in modern publications. For this reason, he has only reached the public partially or has been insufficiently published. The present article tries, precisely for this reason, to bring to light his work in theatre interlude performances by taking a critical look at his most unexplored or unpublished works, starting with the publication of his first anthology of theatrical pieces.
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma
Authors: Ju Gaoda , Zhou Tianhao , Zhang Rui , Pan Xiaozao , Xue Bing , Miao Sen 
Published: August 2021

Background
Dual specificity protein phosphatase (DUSP)12 is an atypical member of the protein tyrosine phosphatase family, which are overexpressed in multiple types of malignant tumors. This protein family protect cells from apoptosis and promotes the proliferation and motility of cells. However, the pathological role of DUSP12 in hepatocellular carcinoma (HCC) is incompletely understood.

Methods
We analyzed mRNA expression of DUSP12 between HCC and normal liver tissues using multiple online databases, and explored the status of DUSP12 mutants using the cBioPortal database. The correlation between DUSP12 expression and tumor-infiltrating immune cells was demonstrated using the Tumor Immune Estimation Resource database and the Tumor and Immune System Interaction Database. Loss of function assay was utilized to evaluate the role of DUSP12 in HCC progression.

Results
DUSP12 had higher expression along with mRNA amplification in HCC tissues compared with those in normal liver tissues, which suggested that higher DUSP12 expression predicted shorter overall survival. Analyses of functional enrichment of differentially expressed genes suggested that DUSP12 regulated HCC tumorigenesis, and that knockdown of DUSP12 expression by short hairpin (sh)RNA decreased the proliferation and migration of HCC cells. Besides, DUSP12 expression was positively associated with the infiltration of cluster of differentiation (CD)4+ T cells (especially CD4+ regulatory T cells), macrophages, neutrophils and dendritic cells. DUSP12 expression was positively associated with immune-checkpoint moieties, and was downregulated in a C3 immune-subgroup of HCC (which had the longest survival).

Conclusion
These data suggest that DUSP12 may have a critical role in the tumorigenesis, infiltration of immune cells, and prognosis of HCC.
Biological Control by Microorganisms
Authors: Harper David R 
Published: July 2021

Abstract

Biological control is the use of natural enemies to reduce the numbers of a damaging organism, which can be anything from a bacterium to a rabbit. Such natural enemies include pathogenic and competitor microorganisms. Biological control agents can be both less toxic and more flexible than chemical pesticides, although given the complexities of biological systems a relatively high level of understanding is required. Although they may be more sympathetically regulated, their high specificity and relative fragility can impose limitations on commercial development. Biological control includes a wide range of approaches, from natural predators to biologically produced molecules. The focus of this article is on microorganisms, including viruses, bacteria, fungi and protozoans. Though many of these cause disease in or poison their target through toxin production, others may act by a different route, for example, by outcompeting the target organism or by excluding it from an ecological niche.

Key Concepts

Biological control is use of material of biological origin to control the numbers or effects of a target organism.

Biological control includes the use of predators, competitors, pathogens and compounds of biological origin.

Microorganisms used include viruses, bacteria, fungi and protozoans. These may cause disease or may compete with or otherwise limit the target organism.

Biological controls tend to be highly specific. Although this generally makes them environmentally benign, it also means that they need to be used in a highly informed way.

Both specificity and the cost and nature of the agents used have limited the use of biological control. All approaches combined account for only around 6% of the global pesticides market, although this figure is rising.
A Highly Ordered, Nanostructured Fluorinated CaP‐Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration
Authors: Daghrery Arwa , Ferreira Jessica A. , de Souza Araújo Isaac J. , Clarkson Brian H. , Eckert George J. , Bhaduri Sarit B. , Malda Jos , Bottino Marco C. 
Published: August 2021

AbstractPeriodontitis is a chronic inflammatory, bacteria‐triggered disorder affecting nearly half of American adults. Although some level of tissue regeneration is realized, its low success in complex cases demands superior strategies to amplify regenerative capacity. Herein, highly ordered scaffolds are engineered via Melt ElectroWriting (MEW), and the effects of strand spacing, as well as the presence of a nanostructured fluorinated calcium phosphate (F/CaP) coating on the adhesion/proliferation, and osteogenic differentiation of human‐derived periodontal ligament stem cells, are investigated. Upon initial cell‐scaffold interaction screening aimed at defining the most suitable design, MEW poly(ε‐caprolactone) scaffolds with 500 µm strand spacing are chosen. Following an alkali treatment, scaffolds are immersed in a pre‐established solution to allow for coating formation. The presence of a nanostructured F/CaP coating leads to a marked upregulation of osteogenic genes and attenuated bacterial growth. In vivo findings confirm that the F/CaP‐coated scaffolds are biocompatible and lead to periodontal regeneration when implanted in a rat mandibular periodontal fenestration defect model. In aggregate, it is considered that this work can contribute to the development of personalized scaffolds capable of enabling tissue‐specific differentiation of progenitor cells, and thus guide simultaneous and coordinated regeneration of soft and hard periodontal tissues, while providing antimicrobial protection.
Double‐Sided Graphene‐Enhanced Raman Scattering and Fluorescence Quenching in Hybrid Biological Structures
Authors: Sarau George , Daniel Christoph , Heilmann Martin , Leuchs Gerd , Amann Kerstin , Christiansen Silke H. 
Published: July 2021

AbstractDue to their large contact and loading surfaces as well as high sensitivities to chemical changes, graphene‐based materials (GBMs) are increasingly being employed into novel nanomedicine technologies. Here biomolecule—monolayer graphene—kidney tissue hybrid structures are studied using mapping micro‐Raman and fluorescence spectroscopies. Because in this configuration graphene interacts with molecules on both sides, a double‐sided graphene‐enhanced Raman scattering (GERS) effect up to ≈10.1 is found for biomolecules adsorbed on graphene and amino acids in the kidney tissue below graphene. Moreover, graphene causes an efficient autofluorescence quenching (FLQ) up to ≈20% emitted by the kidney tissue. Despite the complexity of such layered materials, the intriguing simultaneous occurrence of double‐sided GERS (a new development of GERS) and FLQ phenomena can be well explained by suitable molecular structure and energy level alignment between molecules and graphene. These result in effective charge transfer mediated by non‐covalent interactions as indicated by correlative strain, doping, and defect analyses in graphene based on the Raman data and energy level calculations. Last, the advantages of using graphene over standard photobleaching are demonstrated. This work can be extended to other macromolecular entities toward integrating GBMs in versatile drug delivery, imaging, and sensing devices.
Genesis of Nanogratings in Silica Bulk via Multipulse Interplay of Ultrafast Photo‐Excitation and Hydrodynamics
Authors: Rudenko Anton , Colombier Jean‐Philippe , Itina Tatiana E. , Stoian Razvan 
Published: August 2021

AbstractStructuring below diffraction limit is key to developing new laser processing technologies as well as to understanding light‐induced processes on mesoscopic scales, notably self‐organization. Here, an advanced numerical perspective on the generation of embedded self‐arranged sub‐wavelength periodic patterns is developed, describing multipulse ultrafast laser interaction with bulk silica glass. Combining light and material dynamics, the approach couples self‐consistently nonlinear propagation, electronic excitation, and fluid dynamics resulting in irreversible phase transitions and localized damage. With increasing the number of applied pulses, the modification changes from localized nanovoids and elongated random nanopatterns toward regular void nanogratings dominantly covering the spot of the focused laser beam. Driven by local and collective scattering events, the order imposed by electric field patterns is then amplified and stabilized by the material response. The model predicts the gradual evolution of the optical properties considering the complex interplay between material arrangement and the electromagnetic field distribution. It allows thus to define light transport optical functions optimizing losses and anisotropic effects.
Carbon dioxide enrichment promoted the growth, yield, and light‐use efficiency of lettuce in a plant factory with artificial lighting
Authors: Chen Danyan , Mei Yanhao , Liu Qi , Wu Yongjun , Yang Zhenchao 
Published: August 2021

AbstractLettuce (Latuca sativa L.) is a commercially important crop and a good candidate for production in a plant factory with artificial lighting (PFAL). To explore the influence of CO2 enrichment (eCO2) on lettuce growth, light‐use efficiency (LUE) and various aspects of the growth indicators were specifically assessed. Three CO2 concentrations ([CO2]): ambient CO2 (as the control, approximately 400 μmol mol−1), approximately double the ambient (DA‐CO2, 800 ± 50 μmol mol−1), and approximately quadruple the ambient (QA‐CO2, 1600 ± 50 μmol mol−1) were applied for 30 d. The results indicated that plant height, stem diameter, number of leaves, root length, leaf width, and maximum leaf area were all positively related to [CO2], which illustrated that growth was greater in the treatments with eCO2 than under ambient CO2. The daily average assimilation rate (DAAR), the average dry weight growth rate (GRdw), and yield were also greater for plants grown under DA‐CO2 and QA‐CO2 than under ambient CO2 (DAAR increased by 25.45% and 42.27%, GRdw increased by 28.76 and 37.55%, and yield increased by 33.65 and 44.16%, respectively). Light‐use efficiency increased by 28.51 and 41.12% for DA‐CO2 and QA‐CO2 compared with ambient CO2, respectively. We concluded that eCO2 has the potential to enhance production as well as light utilization in PFAL.
Resilience‐aware design of interconnected supply chain networks with application to water‐energy nexus
Authors: Tsolas Spyridon D. , Hasan M. M. Faruque 
Published: July 2021

AbstractThe effects of natural disasters, pandemic‐induced lockdowns, and other disruptions often cascade across networks. In this work, we use minimum cost of resilience (MCOR) and operation‐based resilience metrics to quantify network performance against single‐connectivity failures and identify critical connections in interconnected networks. MCOR corresponds to the minimum additional infrastructure investment that is required to achieve a certain level of resilience. To guarantee MCOR, we incorporate the metrics in a multi‐scenario mixed‐integer linear program (MILP) that accounts for resilience in the design phase of interconnected networks. The goal is to obtain optimal generation and transportation capacities with flexible operation under all single‐connectivity disruption scenarios. We demonstrate the applicability of our resilience‐aware framework on a water‐energy nexus (WEN) example focusing on grass‐root design and retrofitting. We further apply the framework to analyze a regional WEN and observe that it is possible to achieve “full” resilience in the expense of additional regional investments.