bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural anticoagulants: A missing link in mild to moderate bleeding tendencies
Authors: Mehic Dino , Colling Meaghan , Pabinger Ingrid , Gebhart Johanna 
Published: June 2021

AbstractIntroductionThere is a growing interest in natural anticoagulants as a cause of mild to moderate bleeding disorders (MBDs), particularly in patients with bleeding of unknown cause (BUC), which is defined as having a mild to moderate bleeding phenotype without a definite diagnosis despite exhaustive and repeated laboratory investigations. Recently, abnormalities in two natural anticoagulant pathways, thrombomodulin (TM), and tissue factor pathway inhibitor (TFPI), were identified in single patients or families as the underlying cause for a bleeding tendency.AimThe objective of this review is to discuss the current understanding of the role of natural anticoagulants in MBDs using available clinical and translational data.MethodsA Cochrane Library and PubMed (MEDLINE) search focusing on selected natural anticoagulants and their role in MBDs was conducted.ResultsData on the influence of natural anticoagulants including protein C, protein S, antithrombin, TM, and TFPI or factors with anticoagulant properties like fibrinogen gamma prime (γ’) on MBDs are scarce. Observations from sepsis treatment and from translational research highlight their importance as regulators of the haemostatic balance, especially via the activated protein C‐related pathway, and suggest a role in some MBDs.ConclusionSimilar to the distinct genetic variants of natural anticoagulants linked to thrombosis, we hypothesize that novel variants may be associated with a bleeding tendency and could be identified using next generation sequencing.
Immunoglobulin G4 (IgG4)‐related autoimmune hepatitis and IgG4‐hepatopathy: A histopathological and clinical perspective
Authors: Tanaka Atsushi , Notohara Kenji 
Published: June 2021

AbstractImmunoglobulin G4 (IgG4)‐related disease (IgG4‐RD) is a chronic inflammatory disease that simultaneously or consecutively involves multiple organs of the body. It is characterized by elevated serum IgG4 levels and massive infiltration of IgG4+ plasma cells in the damaged tissues. IgG4‐related autoimmune hepatitis (IgG4‐AIH) and IgG4‐hepatopathy are relatively new entities that have been proposed as a phenotype of IgG4‐RD in the liver. Immunoglobulin G4‐AIH is defined as a disorder with serological, histopathological, and clinical features of both IgG4‐RD and AIH, simultaneously satisfying the diagnostic criteria of both classical AIH and IgG4‐RD. Although there are several case reports and studies of IgG4‐AIH among the published works, no consensus regarding the histopathological characteristics of IgG4‐AIH has been established, and its clinical implications remain obscure. Immunoglobulin G4‐hepatopathy is defined as a comorbidity of IgG4‐RD in the liver, and patients not meeting the diagnostic criteria of classical AIH could be diagnosed with IgG4‐hepatopathy. Numerous issues regarding these diseases, especially their epidemiology, histopathological and clinical characteristics, and treatment response to corticosteroids, remain unsolved, and need to be determined to establish the disease concepts of IgG4‐AIH and IgG4‐hepathopathy.
Organizational justice among registered nurses: A scoping review
Authors: Lönnqvist Katri , Flinkman Mervi , Vehviläinen‐Julkunen Katri , Elovainio Marko 
Published: June 2021

AbstractAimsThis study aimed to describe and summarize research concerning organizational justice among registered nurses.BackgroundOver the recent decades, a number of studies have explored organizational justice. Perceived high organizational justice among employees has been found to correlate with multiple beneficial outcomes, such as job satisfaction, commitment and improved physical and mental health. By contrast, low organizational justice is related to poor productivity, atmosphere at work, health and well‐being.DesignThis study is a scoping review.DataSeven databases were used to search for peer‐reviewed publications published between January 2015 and August 2019.Review methodThis scoping review utilized Arksey and O'Malley's methodological framework.ResultsHigh organizational justice has been found to improve registered nurses' work‐related outcomes, health and well‐being. Low organizational justice has been linked to undesired work‐related outcomes and health problems.ConclusionNurse managers play a key role in promoting organizational justice. Further research is needed to study the relationship between organizational justice and the quality of patient care and safety. There is need for longitudinal studies to understand the effects and nature of organizational justice in the nursing workforce.
Oral mucositis in paediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: Incidence and risk factors
Authors: Miranda‐Silva Wanessa , da Fonseca Felipe Paiva , Gomes Alessandra Araujo , Mafra Ana Beatriz Bechara , Rocha Vanderson , Fregnani Eduardo Rodrigues 
Published: June 2021

AbstractBackgroundOral mucositis (OM) is an important side effect related to allogeneic hematopoietic stem cell transplantation (allo‐HSCT), and it has been associated with a significative reduction of quality of life. A negative impact of OM in paediatric patients could result in increased use of parenteral feeding and opioids, longer periods of hospitalization, and a higher risk of systemic infection.AimTo investigate the clinical features and clinical outcomes associated with OM development and severity in hematological cancer paediatric patients undergoing allo‐HSCT who underwent professional dental care (PDC) and photobiomodulation (PBM) as prophylactic treatment.DesignMedical data and OM presentation were retrieved retrospectively from all patients younger than 18 years who received allo‐HSCT between 2013 and 2016. The incidence of OM was assessed and graded by two oral medicine specialists following the WHO guidelines, and it was correlated with clinical parameters.ResultsForty‐nine consecutive paediatric patients were included. OM was diagnosed in 73.5% of patients, and in 36.1% of patients, OM was classified as severe. Acute lymphoblastic leukemia as a primary diagnosis and the use of a myeloablative regimen were associated with OM development. The primary diagnosis and use of total body irradiation (TBI) were associated with aggressive OM. Neither the incidence nor the severity of OM affected the overall survival, whereas only the use of a myeloablative regimen and a high body mass index (BMI) were determinants of lower OM‐free survival rates.ConclusionsA myeloablative conditioning and a high BMI were observed to be independent prognostic determinants of a lower OMFS rate. The cluster analysis allowed us to outline patient profiles with greater susceptibility to the development and severity of oral mucositis, which seems to be a useful tool to determine the risk of OM in paediatric patients.
Effect of training programmes on nurses' ability to care for subjects with pressure injuries: A meta‐analysis
Authors: Yan Bao , Dandan Huang , Xiangli Meng 
Published: June 2021

AbstractWe performed a meta‐analysis to evaluate the education effects on nurses' ability to care for subjects with pressure injuries. A systematic literature search up to April 2021 was carried out, and 29 studies included 5704 nurses at the start of the study; 3800 of them were experiment or post‐training and 3804 were control or per‐training. They were reporting relationships between the education effects on nurses' ability to care for subjects with pressure injuries. We calculated the odds ratio (OR) or the mean difference (MD) with 95% confidence intervals (CIs) to assess the education effects on nurses' ability to care for subjects with pressure injuries using the dichotomous or continuous method with a random or fixed‐effect model. Experiment or post‐trained nurses had significantly higher knowledge score (MD, 10.00; 95% CI, 7.61‐12.39, P < .001), number of nurses with proper knowledge (OR, 20.70; 95% CI, 10.80‐39.67, P < .001), practice score (MD, 12.39; 95% CI, 5.37‐19.42, P < .001), and number of nurses with proper practice (OR, 3.56; 95% CI, 1.75‐7.25, P < .001), attitudes score (MD, 7.46; 95% CI, 2.94‐11.99, P < .001) compared with control or pertained nurses. Training may have a beneficial effect on improving the nurses' ability to care for subjects with pressure injuries, which was obvious in improving knowledge, practice, and attitudes post‐training. Further studies are required to validate these findings.
Halloysite nanotube‐based superhydrophobic foam for highly efficient oil/water separation
Authors: Zeng Li , Wang Faguo , Han Sumei , Li Moying , Tu Siyang , Lu Qipeng , Cao Wenbin 
Published: June 2021

AbstractOil/water separation is a worldwide concern because of the emissions of oil contaminated wastewater and increasing number of oil spill accidents in recent years. Materials with superhydrophobicity and superoleophilicity provide a new strategy to solve such problems, which allow organic solvents to pass through freely while repelling water. Herein, the porous foams with superhydrophobicity and superoleophilicity were prepared successfully through a facile low‐temperature sintering method, in which the halloysite nanotubes (HNTs), polyvinylidene fluoride (PVDF) and sodium chloride were used as the raw materials. Among them, HNTs constructed the rough surface in micro‐/nano‐scale and sodium chloride served as the sacrifice template. The superhydrophobic surface was achieved via the synergistic effect between the rough surface and PVDF with the low surface energy. The foam showed good water repellency (water contact angle, CA: 156.0 ± 0.1°) and superoleophilic properties, which could selectively absorb organic solvents from the mixture solution with water. Moreover, the foam exhibited high separation efficiencies for a variety of oil/water mixed solutions with excellent cycling stability, which make it a promising material for practical oil/water separation.
CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia‐reperfusion injury
Authors: Sui Mingxing , Xu Da , Zhao Wenyu , Lu Hanlan , Chen Rui , Duan Yazhe , Li Yanhua , Zhu Youhua , Zhang Lei , Zeng Li 
Published: June 2021

AbstractRenal ischaemia‐reperfusion (IR) is a major cause of acute kidney injury (AKI). Cold‐inducible RNA‐binding protein (CIRBP) may contribute to AKI because its deficiency protects against renal IR injury in a mechanism believed to involve ferroptosis. We aimed to investigate whether ferroptosis is associated with CIRBP‐mediated renal damage. The differential expression of CIRBP was examined in tubular epithelial (HK2) cells during hypoxia‐reoxygenation (HR) or in response to erastin, an inducer of ferroptosis. CIRBP expression was increased in response to HR or erastin in HK2 cells but the silencing of CIRBP inhibited HR and erastin‐induced ferroptosis together with ferritinophagy. We discovered an interaction between CIRBP and ELAVL1 using STRING software, which was verified through co‐immunoprecipitation and fluorescence colocalization assays. We found that ELAVL1 is a critical regulator in the activation of ferritinophagy and the promotion of ferroptosis. HR or erastin also induced the expression of ELAVL1. An autophagy inhibitor (hydroxychloroquine) or si‐ELAVL1 transfection reversed CIRBP‐enhanced ferritinophagy activation and ferroptosis in HK2 cells under HR. Injection of anti‐CIRBP antibody into a mouse model of IR inhibited ferroptosis and decreased renal IR injury in vivo. In summary, our results provide evidence that ferritinophagy‐mediated ferroptosis could be responsible for CIRBP‐enhanced renal IR injury.
Pro‐inflammatory signals induce 20α‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal
Authors: Nadeem Lubna , Balendran Rathesh , Dorogin Anna , Mesiano Sam , Shynlova Oksana , Lye Stephen J. 
Published: June 2021

AbstractMetabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α‐HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic or infection‐induced) and associated activation of transcription factors: NF‐кB and AP‐1, common to term and preterm labour. We found that 20α‐HSD protein is significantly increased in human myometrium during term labour, and in mouse uterus during term and preterm labour. Treatment of human myometrial cells with the pro‐inflammatory mediators, lipopolysaccharide (LPS, mimicking infection) and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA, mimicking inflammation), induced 20α‐HSD gene expression and increased 20α‐HSD protein abundance. LPS treatment decreased P4 release into the culture medium and resulted in up‐regulation of GJA1 in the hTERT‐HM cells. The NF‐кB /AP‐1 transcription factors mediated effects of LPS and TPA on 20α‐HSD gene transcription. Both pro‐inflammatory stimuli induced 20α‐HSD promoter activity in LPS/TPA‐treated cells which was significantly attenuated by inhibition of NF‐кB (JSH: 20 µM) or AP‐1 signalling (T5224: 10 µM). Deletion of NF‐кB consensus sites abrogated LPS‐mediated promoter induction, while removal of AP‐1 sites reversed the TPA‐mediated induction of 20α‐HSD promoter. We conclude that inflammatory stimuli (physiologic or pathologic) that activate NF‐кB or AP‐1 induce 20α‐HSD transcription and subsequent local P4 withdrawal resulting in up‐regulation of GJA1 and activation of myometrium that precedes labour.
Predictable 3D guided adhesive bonding of porcelain veneers using 3D printed trays
Authors: Silva Bruno Pereira , Mahn Arteaga Gustavo , Mahn Eduardo 
Published: June 2021

AbstractObjectiveThis clinical report describes a novel digital technique to facilitate and improve the porcelain laminate veneers adhesive bonding procedure using a customized 3D printed guide.Clinical considerationsPorcelain veneers can be stabilized in their fully seated position with a digitally design 3D printed guide before the resin cement is polymerized. The excess cement can be carefully and predictably removed without the risk of dislodgement, rotation or misfit, allowing the clinician to light cure them under controlled pressure in the correct seating position without the risk of fracturing the ceramic material.ConclusionsFabricating a custom 3D printed guide for veneer bonding provides significant assistance to an otherwise cumbersome and daunting clinical procedure.Clinical significanceAdhesive bonding of multiple ceramic veneers is a challenging and technique sensitive procedure. The use of a custom 3D printed guide presented in this article offers a practical aid to achieve a more predictable and precise outcome.
Identification of soybean varieties based on hyperspectral imaging technology and one‐dimensional convolutional neural network
Authors: Li Hao , Zhang Liu , Sun Heng , Rao Zhenhong , Ji Haiyan 
Published: June 2021

AbstractVariety identification of seeds is essential to ensure the purity and yield of the variety. A model based on hyperspectral imaging technology and one‐dimensional convolutional neural network (1D CNN) was proposed to distinguish soybean seed varieties in this article. A total of 3,600 soybean seeds (900 seeds per variety) of hyperspectral images in the spectral range of 866.4–1,701.0 nm were collected. Traditional machine learning models (k‐nearest neighbor, support vector machines, partial least squares discriminant analysis) and 1D CNN model were established based on different numbers of sample sets. The 1D CNN model was the most stable and had the highest classification accuracy, higher than 98%. Fivefold cross validation was used to evaluate the model, and the model achieved an accuracy of more than 95% in both the training set and the validation set. Finally, the t‐distributed stochastic neighbor embedding was used to visualize the feature values extracted by 1D CNN. The research results demonstrated that the 1D CNN model maintained good classification performance in soybean seed classification and had good application prospects in hyperspectral imaging technology.Practical ApplicationsVariety identification of soybean seeds is essential to ensure the purity and yield of the variety. Different soybean varieties have different genetic purity, physical purity, germination ability and vigor, which are related to quality attributes, such as nutritional value, stress resistance, and final yield. In the past, most soybeans were identified using traditional machine learning algorithms combined with near‐infrared hyperspectral imaging technology to build models. This requires a series of operations, such as smoothing preprocessing and dimensionality reduction on hyperspectral data. These steps are too cumbersome and are not conducive to online hyperspectral monitoring systems. The results of this study show that it is feasible to use one‐dimensional convolutional neural network combined with hyperspectral technology to identify soybean seeds, and it also provides a new idea for building an online detection system in the future.
¡Qué mamada! (What a Joke!): Humor, Hostility, and Hospitality along the Central American Migrant Trail
Authors: Doering‐White John 
Published: June 2021

AbstractAlong the Central American migrant trail through Mexico, jokes and teasing offer a window into a transnational border regime defined by both migrant hospitality and xenophobic hostility. Based on ethnographic fieldwork in a welding workshop in Monterrey, a city in Northern Mexico where Central Americans are increasingly waylaid on journeys to the US‐Mexico border, this article examines playfully derisive and sexually charged jokes, enacted materially through everyday objects like pickup trucks, coke bottles, and welding torches, as rhetorical strategies that migrant guests rely on to negotiate the contradictions of welcome and trespass that anthropologists have largely discussed through the lens of humanitarianism. These dynamics illuminate how intersecting migrant communities reify and reconfigure ambiguities of solidarity and suspicion that surround transit migration as ethical‐moral border regimes increasingly push migrant communities toward informal hospitality spaces at the margins of the West.
Workplace bullying, personality traits and health among hospital nurses: The mediating effect of social support
Authors: Fang Li , Hsiao Li‐Ping , Fang Shu‐Hui , Chen Bao‐Chen 
Published: June 2021

AbstractAims and objectivesThis study aimed to explore the status of nursing staff's workplace bullying, personality traits, social support and mental health, to find out the predictors of nursing staff's health, and to explore whether social support is a mediator to regulate the impact of workplace bullying on mental health.BackgroundBullying could cause physical and psychological problems, and nursing workplace bullying causes not only health problems of nursing staff but also patient safety problems. "Workplace bullying" is a worthy topic to pay attention to. Only limited studies could be discovered about the mediating effects between workplace bullying and health.MethodsCross‐sectional and correlation designs were used. The STROBE was used as a checklist for this study.ResultsThe results showed that the frequency of poor sleep quality ≥3 days in recent 2 weeks (p < .001), external control personality traits (p = .016), workplace bullying (p < .001) and less social support (p = .001) were the main predictors of the health problems among nurses, and social support was the mediator between workplace bullying and health problems.ConclusionIt is recommended that hospital managers should apply regular sleep–wake schedule by designing a biological clock‐compliant shift in order to promote good sleep hygiene of the nurses. Providing educational programmes and building up policies to decrease workplace bullying and increase social supports are suggested.Relevance to clinical practiceHospital managers should provide education and training related to the prevention of bullying and establish communication and consultation channels for the bullied. Nursing managers should also educate nurses to establish effective social networks with family, friends and colleagues to prevent health problems.
Serum levels of perfluorooctanoic acid and perfluorooctane sulfonic acid in pregnant women: Maternal predictors and associations with birth outcomes in the PIPA Project
Authors: Espindola Santos Aline de Souza , Meyer Armando , Dabkiewicz Vanessa Emídio , Câmara Volney de Magalhães , Asmus Carmen Ildes Rodrigues Froes 
Published: June 2021

AbstractAimPerfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent pollutants associated with adverse birth outcomes. This study aimed to identify predictors of blood PFOA and PFOS concentrations in pregnant women and to estimate their associations with birth outcomes in Brazil.MethodsWe conducted a cross‐sectional study with 139 pregnant women enrolled in the pilot study of the Rio Birth Cohort Study on Environmental Exposure and Childhood Development (PIPA Project). Multiple linear regression was used to estimate associations between PFOA and PFOS with maternal predictors and birth outcomes.ResultsHigher levels of PFOA were observed in women aged 16–19 and 20–39 years, while fish consumption from 0.6 to 2.0 times per week was associated with lower levels of the substance. PFOS levels were higher in women living in houses with up to four rooms but lower in those who reported passive exposure to smoking. Increased newborn length and head circumference were also associated with higher maternal levels of PFOA.ConclusionsIn our study, age, fish consumption, passive smoking, and the number of rooms in the house were predictors of maternal PFAS levels. However, we did not observe significant associations between maternal plasma PFAS concentrations and birth outcomes.
Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications
Authors: Butcher S. C. , Fortuni F. , Dietz M. F. , Prihadi E. A. , van der Bijl P. , Ajmone Marsan N. , Bax J. J. , Delgado V. 
Published: June 2021

AbstractBackgroundThe pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which pathophysiological mechanisms related to TR are independently associated with renal dysfunction and to evaluate the impact of renal impairment on long‐term prognosis in patients with significant (≥ moderate) secondary TR.MethodsA total of 1234 individuals (72 [IQR 63–78] years, 50% male) with significant secondary TR were followed up for the occurrence of all‐cause mortality and the presence of significant renal impairment (eGFR of <60 mL min−1 1.73 m−2) at the time of baseline echocardiography.ResultsMultivariable analysis demonstrated that severe right ventricular (RV) dysfunction (TAPSE < 14 mm) was independently associated with the presence of significant renal impairment (OR 1.49, 95% CI 1.11 to 1.99, P = 0.008). Worse renal function was associated with a significant reduction in survival at 1 and 5 years (85% vs. 87% vs. 68% vs. 58% at 1 year, and 72% vs. 64% vs. 39% vs. 19% at 5 years, for stage 1, 2, 3 and 4–5 CKD groups, respectively, P < 0.001). The presence of severe RV dysfunction was associated with reduced overall survival in stage 1–3 CKD groups, but not in stage 4–5 CKD groups.ConclusionsOf the pathophysiological mechanisms identified by echocardiography that are associated with significant secondary TR, only severe RV dysfunction was independently associated with the presence of significant renal impairment. In addition, worse renal function according to CKD group was associated with a significant reduction in survival.