bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of Cerebellar Neural Circuits in Active Avoidance Conditioning in Zebrafish
Authors: Koyama Wataru , Hosomi Ryo , Matsuda Koji , Kawakami Koichi , Hibi Masahiko , Shimizu Takashi 
Published: May 2021

AbstractWhen animals repeatedly receive a combination of neutral conditional stimulus (CS) and aversive unconditional stimulus (US), they learn the relationship between CS and US, and show conditioned fear responses after CS. They show passive responses such as freezing or panic movements (classical or Pavlovian fear conditioning), or active behavioral responses to avoid aversive stimuli (active avoidance). Previous studies suggested the roles of the cerebellum in classical fear conditioning but it remains elusive whether the cerebellum is involved in active avoidance conditioning. In this study, we analyzed the roles of cerebellar neural circuits during active avoidance in adult zebrafish. When pairs of CS (light) and US (electric shock) were administered to wild-type zebrafish, about half of them displayed active avoidance. The expression of botulinum toxin, which inhibits the release of neurotransmitters, in cerebellar granule cells (GCs) or Purkinje cells (PCs) did not affect conditioning-independent swimming behaviors, but did inhibit active avoidance conditioning. Nitroreductase (NTR)-mediated ablation of PCs in adult zebrafish also impaired active avoidance. Furthermore, the inhibited transmission of GCs or PCs resulted in reduced fear-conditioned Pavlovian fear responses. Our findings suggest that the zebrafish cerebellum plays an active role in active avoidance conditioning.
Intramuscular fatty infiltration and physical function in controlled acromegaly
Authors: Martel-Duguech Luciana , Alonso-Pérez Jorge , Bascuñana Helena , Díaz-Manera Jordi , Llauger Jaume , Nuñez-Peralta Claudia , Montesinos Paula , Webb Susan M , Valassi Elena 
Published: May 2021

Introduction
Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders.

Objective
To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients and its relationship with muscle dysfunction.

Methods
In a cross-sectional study, we included 36 patients with controlled acromegaly and 36 matched controls. We assessed the percentage of fat fraction in each thigh muscle, using MRI 2-point Dixon sequence, and muscle performance and strength using the gait speed, timed up and go, 30-s chair stand, and hand grip strength tests. We evaluated joint symptoms using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC).

Results
Intramuscular fat fraction was greater in patients than controls (P < 0.05 for muscle compartments, rectus femoris (RF), vastus intermedius (VI), adductor magnus (AM) and semimembranosus). Patients had slower gait speed and poorer performance on the 30-s chair stand and timed up and go tests than controls (P < 0.05). The greater fat fraction in the combined anterior–posterior compartment and in each muscle was associated with worse performance on timed up and go (P < 0.05). The fat fraction in the anterior–posterior compartment predicted performance on timed up and go after adjusting for muscle area, IGF-I and WOMAC functional and pain scores (β = 0.737 P < 0.001).

Conclusions
Patients with controlled acromegaly have greater thigh i.m. fatty infiltration, which is associated with muscle dysfunction. Futures studies are needed to elucidate the mechanisms underlying this relationship.
Pendampingan Keterampilan Mengenali dan Mencegah Thalassemia Pada Masyarakat
Authors: Safyudin Safyudin , Sinulingga Sadakata , Fatmawati Fatmawati , Subandrate Subandrate , Haryadi Kusumo , Yana Rini , Romadhon M Fitra , Monanda M Dias Athallah 
Published: May 2021

Abstract:Thalassemia is a genetic disease that is inherited through marriage. At present, the incidence of thalassemia can only be reduced by reducing the birth of thalassemia children. Giving a correct understanding to the community is the right way to prevent the increase in new thalassemia sufferers. This community service activity is carried out in Lubuklinggau City, South Sumatra by involving lecturers who focus on the prevention of thalassemia. Activities carried out in the form of counseling and demonstration about thalassemia to 56 participants. In this activity, the demonstration was carried out using tools such as brochures / leaflets. An evaluation of the success of the activity is carried out using random questions to the participants before and after the activity. After counseling, most participants understood the simple way to recognize and prevent thalassemia. From these community service activities, it can be concluded that counseling and demonstration, can be used to improve people's knowledge and simple skills in recognizing and preventing thalassemia. Keywords: Counseling, prevent, recognize, thalassemia Abstrak: Thalassemia merupakan penyakit genetik yang diturunkan melalui perkawinan. Saat ini, angka kejadian penyakit thalassemia hanya dapat turunkan dengan cara mengurangi kelahiran anak thalassemia. Pemberian pemahaman yang benar kepada masyarakat merupakan cara yang tepat guna mencegah peningkatan penderita thalassemia baru. Kegiatan pengabdian masyarakat ini dilakukan di Kota Lubuklinggau, Sumatera Selatan dengan melibatkan dosen yang fokus pada usaha pencegahan thalassemia. Kegiatan yang dilakukan berupa penyuluhan dan demonstrasi tentang thalassemia terhadap 56 orang peserta. Dalam kegiatan ini, demontrasi dilakukan dengan menggunakan alat bantu berupa brosur/leaflet. Evaluasi terhadap keberhasilan kegiatan dilakukan dengan menggunakan pertanyaan acak kepada peserta sebelum dan sesudah kegiatan. Setelah penyuluhan, sebagian besar peserta memahami cara sederhana mengenali dan mencegah thalassemia. Dari kegiatan pengabdian masyarakat ini, dapat simpulkan bahwa penyuluhan dan demonstrasi, dapat digunakan untuk meningkatkan pengetahuan dan keterampilan sederhana masyarakat dalam mengenali dan mencegah thalassemia. MIOS. Kata Kunci: Mencegah, mengenali, penyuluhan, thalassemia
Model Pembelajaran Predict, Observe, Explain (POE) Terhadap Keterampilan Proses Sains Siswa Pada Materi Larutan Elektrolit dan Nonelektrolit
Authors: Mutiyah Citra , Irawan Dedi , Bahriah Evi Sapinatul 
Published: May 2021

Abstract:This study aims to determine the effect of Predict, Observe, Explain (POE) learning models on students' science process skills on electrolyte and non-electrolyte solution materials. The subjects in this study were students of class X at SMA Negeri 89 East Jakarta in the academic year 2013/2014. The research method applied was a quasi-experimental design with nonequivalent control group design. Samples were taken by purposive sampling and divided into 2 groups, namely the experimental group and the control group. The instruments used in this study were essay test instruments and observation sheets. Data analysis techniques were obtained using the "t" test. The results showed that the use of Predict, Observe, Explain (POE) learning models had an influence on students' science process skills in electrolyte and non-electrolyte solution materials. Keywords: learning model of Predict, Observe, Explain (POE); Science process skills; Electrolyte and Non-electrolytes solution Abstrak:Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Predict, Observe, Explain (POE) terhadap keterampilan proses sains siswa pada materi larutan elektrolit dan nonelektrolit. Subyek dalam penelitian ini adalah siswa kelas X di SMA Negeri 89 Jakarta Timur tahun ajaran 2013/2014. Metode penelitian yang diterapkan adalah kuasi eksperimen dengan desain nonequivalent control group design. Sampel diambil secara purposive sampling dan dibagi 2 kelompok, yaitu kelompok eksperimen dan kelompok kontrol. Instrumen yang digunakan dalam penelitian ini adalah instrumen tes essay dan lembar observasi. Teknik analisis data diperoleh menggunakan uji “t”. Hasil penelitian menunjukkan bahwa penggunaan model pembelajaran Predict, Observe, Explain (POE) memberikan pengaruh terhadap keterampilan proses sains siswa pada materi larutan elektrolit dan nonelektrolit. Kata Kunci: Keterampilan proses sains; Larutan elektrolit dan nonelektrolit; Model pembelajaran Predict, Observe, Explain (POE).
Dakwah Tuan Guru Baba Abdulkarim bin Hasbullah Naknawa
Authors: Salaeh Miss Yamilah , Shodiqin Asep 
Published: May 2021

This study aims to obtain a factual description in the form of an explanation of the mission of Mr. Guru Baba Abdulkarim. This research was conducted at Pondok Dala Islamic Boarding School in Pattani. Data collected through involed observations, in-depth interview and literature. Data analysisi is carried out inductively through interpretation of information related to social context. In this study explained that the master of the Baba theacher has a variety of methods and matrials in delivering his message. Among the tabligh methods used by maters Baba is the lecture method, the question and answer method, discussion method, halaqah method and exemplary method. The result of this study that the teacher has a different tabligh method and have different material depending on how the condition of the community, so that the theme delivered can also be in accordance with the circunstances at that time. Jema’ah tabligh a good response to tabligh Mr. Baba, so that every time there is a recitation of the Mr. Baba, the pilgrims come in droves from all over the region.
Tulisan ini bertujuan untuk memperoleh gambaran factual berupa penjelasan tentang dakwah Tuan Guru Baba Abdul Karim Bin Hasbullah Naknawa, penelitian ini dilakukan di Pesantren Pondok Dala di Pattani, penelitian ini menjelaskan tentang bagaimana proses dan cara dakwah Tuan Guru Baba. Tulisan ini dilakukan dengan cara metode kualitatif dan data diambil secara purposif. Data dikumpulkan melalui observasi terlibat, wawancara mendalam dan kepustakaan. Analisis data dilakukan secara induktif melalui interpretasi informasi dihubungkan dengan konteks social. Dalam tulisan ini dijelaskan bahwa Tuan Guru Baba memiliki berbagai macam metode dan materi dalam menyampaikan dakwahnya, diantara metode tabligh yang digunakan oleh Tuan Guru Baba adalah metode ceramah, metode tanya jawab, metode diskusi, metode halaqah dan metode keteladanan. Hasil penelitian ini bahwa Tuan Guru Baba memiliki metode tabligh yang berbeda – beda dan memiliki materi tabligh yang berbeda pula tergantung bagaimana kondisi masyarakat sehingga tema yang disampaikan bisa sesuai dengan keadaan pada waktu itu. Jema’ah tabligh juga memberikan respon yang baik terhadap tabligh Tuan Guru Baba, sehingga setiap kali ada pengajian Tuan Guru Baba maka para jema’ah datang berbondong – bondong dari seluruh wilayah.
Pola Tabligh Ustadz Cinta Pemuda di Kalangan Remaja Masjid Agung Kota Sukabumi
Authors: Angelia Rima , Muhyiddin Asep , Sukayat Tata 
Published: May 2021

This study aims to find out and describe the Tabligh Pattern of Ustadz Cinta, which includes concepts, methods, media, and the content of the messages discussed in the Mahbbah Assembly study in the Great Mosque of Sukabumi City. The method used is descriptive method, the type of data used in this study is a type of qualitative data, data collection techniques using observation techniques, interview techniques, and using documentation techniques. The results can be seen that the tabligh pattern used by the religious teacher in the Mahabbah Assembly study is four, namely: concepts, media, message content, and methods used. the concept can provide new innovations in conveying tabligh khitobah, in terms of the content of the message which has the theme of love, the methods used include lectures, discussion / question and answer, and muhasabah, the media uses modern tools that is using laptops, infokus, pulpit, and mic.
Penelitian ini bertujuan untuk mengetahui dan menggambarkan Pola Tabligh Ustadz Cinta, yang meliputi konsep, metode, media, dan isi pesan yang di bahas dalam kajian Majelis Mahbbah di Masjid Agung Kota Sukabumi. Metode yang dipakai adalah metode deskriptif, Jenis data yang digunakan dalam penelitian ini adalah jenis data kualitatif, teknik pengumpulan data menggunakan teknik observasi, teknik wawancara, dan menggunakan teknik dokumentasi. Hasilnya dapat diketahui bahwa pola tabligh yang dipakai oleh ustadz cinta dalam kajian Majelis Mahabbah ada empat, yaitu: konsep, media, isi pesan, dan metode yang digunakan. konsep dapat memberikan inovasi baru dalam menyampaikan tabligh khitobah, dari segi isi pesannya yang meimiliki tema tentang cinta, metode yang digunakan diantaranya ceramah, diskusi/tanya jawab, dan muhasabah, medianya menggunakan alat yang modern yaitu dengan menggunakan laptop, infokus, mimbar, dan mic.
Strategi Komunikasi Dakwah Da’i Hidayatullah dalam Pembinaan Masyarakat Pedesaan
Authors: Arifin Bustanol 
Published: May 2021

This paper aims to determine the da'i Hidayatullah da'wah communication strategy in fostering rural communities which are formulated into three questions as follows: the role of da'i Hidayatullah in raising awareness of rural communities. The diffusion of da'i Hidayatullah's da'wah communication in fostering rural communities and the innovation of da'i Hidayatullah's da'wah communication in fostering rural communities in Cimenyan district, Bandung regency. The research method uses descriptive methods by making the da'i Hidayatullah Bandung district that fosters rural communities as the main source of this research. This type of research is qualitative. The results showed that the Hidayatullah preacher had a role as a change agent by conducting persuasive-informative communication in raising and fostering rural communities in the Cimenyan sub-district, Bandung regency. The diffusion of da'wah communication carried out by Hidayatullah in developing rural communities in the Cimenyan district of Bandung district through activities in the form of majelis ta'lim, grand MBA, training of bina aqidah, qur'an education park (TPA) and mosque youth in which da'wah messages in the form of aqeedah, shari'ah, and morals. Da'i Hidayatullah's innovation in da'wah communication was in the form of implementing an empowerment program which included empowering human resources (HR) and the community economy which was formed through training and recitation activities.

Tulisan ini bertujuan untuk mengetahui strategi komunikasi dakwah da’i Hidayatullah dalam membina masyarakat pedesaan yang dirumuskan menjadi tiga pertanyaan sebagai berikut: peran da’i Hidayatullah dalam menyadarkan masyarakat pedesaan. Difusi komunikasi dakwah da’i Hidayatullah dalam membina masyarakat pedesaan dan inovasi komunikasi dakwah da’i Hidayatullah dalam membina masyarakat pedesaan di kecamatan Cimenyan kabupaten Bandung. Metode penelitian menggunakan metode deskriptif dengan menjadikan da’i Hidayatullah kabupaten Bandung yang membina masyarakat pedesaan sebagai sumber utama dalam penelitian ini. Jenis penelitian adalah kualitatif. Hasil penelitian menunjukkan bahwa da’i Hidayatullah berperan sebagai agen perubah dengan melakukan komunikasi persuasif-informatif dalam menyadarkan dan membina masyarakat pedesaan di kecamatan Cimenyan kabupaten Bandung. Difusi komunikasi dakwah yang dilakukan oleh da’i Hidayatullah dalam membina masyarakat pedesaan di kecamatan Cimenyan kabupaten Bandung melalui kegiatan berupa majelis ta’lim, grand MBA, training bina aqidah, taman pendidikan al-qur’an (TPA) dan remaja masjid yang didalamnya disampaikan pesan-pesan dakwah berupa pesan aqidah, syari’ah, dan akhlak. Inovasi komunikasi dakwah yang dilakukan oleh da’i Hidayatullah berupa penyelenggaraan program pemberdayaan yang meliputi pemberdayaan sumber daya manusia (SDM) dan ekonomi masyarakat yang dibentuk melalui kegiatan pelatihan dan pengajian.
Pesan Dakwah dalam Program Televisi Muslim Travelers NET.
Authors: Wijaya Muhammad Deni , Sumijaty Siti , Fatoni Uwes 
Published: May 2021

This research discusses the da'wah messages that exist in the Muslim Traveler NET television program. the messages conveyed are adapted to media functions that are informative, persuasive and entertaining. The method used in this study is a qualitative content analysis using a coding sheet, then analyzed together with the resulting data collection made in a descriptive qualitative form. The results of this study found 31 da'wah messages that fit the categories in the study, namely 15 informative da'wah messages, 13 persuasive da'wah messages and 3 entertainment da'wah messages from 5 episodes of Muslim travelers airing in 2018 namely 3 South Korean episodes, 1 South American episode and 1 episode of Spain. informative da'wah messages that discuss a lot about the arrival of Islam, Islamic symbols and information about halal food, persuasive da'wah messages motivate and encouragement to uphold Islamic Shari'a, worship also da'wah and the last, entertainment da'wah message of that displays culture, panorama and artwork.
Penelitian ini membahas tentang pesan dakwah yang ada pada program televisi muslim travelers NET. pesan yang dibahas disesuaikan dengan fungsi media yaitu informatif, persuasif dan hiburan. Metode yang digunakan dalam penelitian ini ialah analisis isi kualitatif dengan menggunakan coding sheet, lalu dianalisis bersamaan dengan pengumpulan data yang hasilnya dibuat dalam bentuk deskriptif kualitatif. Hasil dari penelitian ini ditemukan 31 pesan dakwah yang sesuai dengan kategori dalam penelitian, yaitu 15 pesan dakwah informatif, 13 pesan dakwah persuasif dan 3 pesan dakwah hiburan dari 5 episode muslim travelers yang ditayangkan tahun 2018 yaitu 3 episode Korea Selatan, 1 episode Amerika dan 1 episode Spanyol. Pesan dakwah informatif banyak membahas tentang kedatangan Islam, syiar Islam dan informasi tentang makanan halal, pesan dakwah persuasif meliputi ajakan dan motivasi untuk menegakan syariat Islam, beribadah juga berdakwah dan pesan dakwah hiburan yang menampilkan pemandangan, kebudayaan alam dan karya seni.
Pesan Dakwah dalam Produk Anak Muslim Afrakids
Authors: Nurjamilatunnisa Septi , Sarbini Ahmad , Fakhruroji Moch. 
Published: May 2021

This study aims to determine the categorization of da'wah messages including the message of faith, moral messages and sharia messages contained in the catalog of shirts. The method used in this study is to use analytical methods using symbol coding, reporting and interpretation techniques. Using data reporting techniques, literature study and categorization. In this study it can be concluded that Afrakids Muslim children's products have a message category with a total of 2 messages or a percentage of 7.7%, has a message categorization with a total of 18 messages or a percentage of 69.2%, and has a sharia message categorization with a total of 6 messages or percentage of 23.1%. Of the three categorization messages of da'wah, do more using messages for children in instilling the values ​​of Islamic teachings in daily life. Followed by the Sharia message and the least message of faith.
Penelitian ini bertujuan untuk mengetahui kategorisasi pesan dakwah meliputi pesan akidah, pesan akhlak serta pesan syariah yang ada pada katalog kaos tersebut. Adapun metode yang dilakukan dalam penelitian ini adalah menggunakan metode analisis isi dengan menggunakan teknik symbol coding, mencatat lambang atau pesan secara sistematis kemudian diberi interpretasi. Adapun teknik pengumpulan datanya melalui dokumentasi, studi pustaka dan kategorisasi. Dalam penelitian ini dapat disimpulkan bahwa produk anak muslim Afrakids memiliki kategori pesan akidah dengan jumlah 2 pesan atau persentase sebanyak 7,7%, memiliki kategorisasi pesan akhlak dengan jumlah 18 pesan atau persentase sebanyak 69,2%, dan memiliki kategorisasi pesan syariah dengan jumlah 6 pesan atau persentase sebanyak 23,1%. Dari ketiga kategorisasi pesan dakwah tersebut, cenderung lebih banyak menggunakan pesan akhlak untuk anak dalam menanamkan nilai-nilai ajaran Islam dalam kehidupan sehari-hari. Disusul dengan pesan syariah dan pesan akidah yang paling sedikit.
Differential Effects of Endothelin-1 Antagonists on Erythropoietin-Induced Hypertension in Renal Failure
Authors: BROCHU EDITH , LACASSE-M SONIA , LARIVIÈRE RICHARD , KINGMA IRIS , GROSE JOHN H. , LEBEL MARCEL 
Published: May 2021

Abstract.
Recently, it was reported that blood vessel immuno-reactive endothelin-1 (irET-1) content is increased in hypertensive uremic rats treated with recombinant human erythropoietin (rhEPO). The present study was designed to evaluate whether ET-1 receptor blockade can prevent the progression of hypertension in renal failure rats receiving rhEPO and, if so, whether selective ETA and nonselective ETA/ETB receptor antagonists are equally effective. Renal failure was induced by a two-stage 5/6 nephrectomy; the animals developed uremia, anemia, and hypertension. After a 4-wk stabilization period, the animals received either rhEPO (100 U/kg, subcutaneously, three times per week) or the vehicle for 4 wk. In protocol A, half of the rats in each group were simultaneously treated with the ETA/ETB receptor antagonist bosentan (100 mg/kg per d). In protocol B, half of the rats in each group received the selective ETA receptor antagonist LU135252 (50 mg/kg per d). Systolic BP was recorded before and at 2 and 4 wk after the onset of treatment. Serum creatinine levels and hematocrit were measured before treatment and at the end of the study. Creatinine clearance rates and plasma irET-1 concentrations were determined at the end of the study. rhEPO corrected the anemia, but aggravated the hypertension. There was a slight and similar increase in serum creatinine throughout the treatment period in all groups of rats. Both ET-1 receptor antagonists bosentan and LU135252 were effective in attenuating the progression of hypertension in uremic rats receiving the vehicle (P < 0.05). Treatment with LU135252 corrected the increase in BP in rhEPO-treated rats (160 ± 7 mmHg versus 187 ± 9 mmHg, P < 0.05). In contrast, bosentan did not attenuate the progression of hypertension in rhEPO-treated rats (172 ± 10 mmHg versus 168 ± 9 mmHg, NS). In summary, selective ETA but not ETA/ETB receptor blockade can prevent the aggravation of hypertension in renal failure rats treated with rhEPO. These results suggest that the endothelin system may be involved in the pathogenesis of rhEPO-induced hypertension in uremic rats with a differential role for ETA and ETB receptors.