bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCO 20 years: key achievements and the role of China
Authors: Shkvarya Lyudmila V. 
Published: October 2021

The article analyzes the process of development of the Shanghai Cooperation Organization (SCO) in the historical aspect and its current state. SCO was created as a regional association to maintain stability and security. Today, China is stepping up its efforts to boost regional economic cooperation.
Based on the analysis of UNCTAD statistics for 2001-2019, the authors justified the conclusion that the economic potential of the SCO has significantly increased. However, this growth is not related to the economic interaction in SCO, but with the expansion, and with the growth of the individual countries’ economies, primarily the PRC.
The analysis confirms, that the share of bilateral trade and the volume of mutual (especially Chinese) investments in the SCO are growing. International cooperation in certain areas has little real support at the level of the Organization as a whole. At the same time, the existing successes of the SCO countries in the economic sphere, the attraction of significant foreign investment and modern technologies, the gradual diversification of national economies, as well as new initiatives of the People&apos;s Republic of China, determine the deepening of economic cooperation, the mechanisms of which are of scientific interest.
The relevance of the study is determined by the need to study the peculiarities of the SCO evolution and the positions of individual countries in SCO. The study makes a significant contribution to the understanding of the nature and features of the processes of economic cooperation and development in the region and the positions of individual countries.
Clinical correlation between coagulation disorders and sepsis in patients with liver failure
Authors: Li Lei , Chen Ling , Wang Han , Li Peiran , Wang Dan , Zhang Wei , Mi Lai , Lin Fang , Qin Yuling , Zhou Yuesu 
Published: October 2021

OBJECTIVE: This study aimed to explore the clinical detection and prognosis of coagulation function in patients with liver failure and sepsis. METHODS: The plasma fibrinogen (FIB), factor II, factor VII, factor V, factor IV, antithrombin III (ATIII), platelet (PLT), mean PLT volume (MPV), D-dimer, prothrombin activity (PTA), and fibrin degradation product (FDP) levels and thromboelastogram values were detected in patients with liver failure complicated with sepsis and compared with those in the liver failure and liver cirrhosis groups. The patients with liver failure complicated with sepsis were analyzed by univariate and multivariate logistic regression, and the regression equation was established. RESULTS: The levels of FIB, factor II, factor VII, factor V, ATIII, PLT, MPV, D-dimer, and FDP in the patients with liver failure complicated with sepsis were compared with those in the control group patients, and the differences were statistically significant ( p < 0.05). Among the thromboelastography parameters in the patients with liver failure and sepsis, the differences in the K-value, R-value, angle, maximum amplitude, and coagulation index values compared with those of the control group were statistically significant ( p < 0.05). The logistic regression model obtained was as follows: p = 1/(1 + e [–0.128×X1–0.058×X2 + 0.211×X3 + 0.2×X4 + 0.25]). The specificity, sensitivity, and accuracy values of the regression equation in determining the prognosis were 92%, 93.9%, and 92.8%, respectively. Among the 11 factors, factor VII, PLT, FDP, and D-dimer were included in the regression equation. CONCLUSION: Coagulation disorder is exacerbated in patients with liver failure and sepsis. Among the 11 coagulation-related factors, factor VII, PLT, FDP, and D-dimer may be the independent factors influencing the prognosis of patients with acute liver failure and sepsis.
Adaptação de Estudantes Universitários Estrangeiros no Brasil: Revisão de Escopo
Authors: Possa Zembrzuski Letícia Janaina , Maria Reis Capellani dos Santos Clenise , Kenji Nihei Oscar 
Published: October 2021

Este artigo aborda a adaptação dos estudantes universitários estrangeiros no Brasil dentro da perspectiva da internacionalização do Ensino Superior e foi motivado pela necessidade de compreender a realidade desses estudantes que buscam capacitação fora de seu país de origem. Procurou-se analisar os avanços sobre o tema nos últimos anos e que necessitam ser esclarecidos através de análises que induzem a medidas de balizamentos teóricos e empíricos estabelecidos para entender os fluxos estudantis e os fatores facilitadores e dificultadores envolvidos. Assim, objetivou-se analisar o processo de adaptação de estudantes universitários estrangeiros nas universidades brasileiras. O método adotado foi a da revisão de escopo que compreende o emprego de buscas em bases bibliográficas online de publicações entre 2009 a 2019, utilizando como pergunta norteadora: “Quais os fatores que incidem na adaptação dos estudantes estrangeiros imigrantes ao buscar uma formação universitária no Brasil? ”. Como resultado da pesquisa, foram selecionados 11 estudos que atenderam aos critérios de inclusão. Esses estudos apontaram que há elementos facilitadores como à rede de amizades e relações sociais, a assistência estudantil, o idioma e aspectos culturais e afetivos, mas também há dificultadores da adaptação relacionados às dificuldades da vida cotidiana (adaptação alimentar, moradia, saúde, custo de vida, clima e segurança), assim como, de natureza social e também afetiva representado pelo preconceito e discriminação que sofrem e a ausência familiar, levando a sofrimento psíquico, ao mesmo tempo que indicam que as políticas públicas de acolhimento e assistência estudantil nas universidades necessitam ser aprimoradas, para assim atuarem na redução da evasão nas universidades.

Palavras-chaves: Internacionalização. Adaptação de estudantes estrangeiros. Acolhimento.
Clinical Efficacy Test of Polyester Dressing Containing Herbal Extracts and Silver Sulfadiazine Cream Compared with Silver Sulfadiazine Cream in Healing Burn Wounds: A Prospective Randomized Controlled Trial
Authors: Tianwattanatada Suttipong , Namviriyachote Nantaporn , Chinaroonchai Kusuma , Owattanapanich Natthida , Nair Harikrishna K.R. , Muangman Pornprom 
Published: October 2021

The standard burn wound treatment is the application of silver zinc sulfadiazine cream, covered with sterilized gauze dressing. This method has been used for decades because of its reasonable costs and applicability for larger wound sizes. However, gauze with a large pore size may stick to the wound bed and cause wound trauma, leading to delayed healing. The patient may also experience additional pain during changing the dressing. The non-adherent property of a hydrocolloid dressing coated with herbal extract (SIHERB) can promote wound healing as well as reduce pain.
This study compared the two methods of burn wound treatment in the same patients, who were split into a “treatment group”, who were applied both silver sulfadiazine cream and hydrocolloid dressing, and “control group”, who were applied only silver sulfadiazine cream. The studied outcomes were the number of days for wound closure, the percentage epithelialization, and the pain score (evaluated every three days until epithelialization was completed). In total, 24 patients at the Burn Clinic, Siriraj Hospital were enrolled on this study. The starting wound areas were ranged from 210–220 cm2. The treatment group exhibited significant results regarding faster wound healing, referring to the number of days taken for wound closure (18 days in the control group vs. 15 days in the experimental group) and the percentage epithelialization compared to the control group. The average pain score in the experimental group was also lower on days 9, 12, and 15 after treatment (p < 0.05). No adverse effects were observed during the study.
In conclusion, the combination of hydrocolloid dressing and silver sulfadiazine cream could reduce the wound shearing force and wound bed injury, accelerating the rate of wound closure and decreasing the pain during changing the dressing. This technique could improve upon the standard burn wound treatment.
Copyright and fundamental rights to freedom of the information, the press: EU judicial practice
Authors: Trotska Valentyna 
Published: October 2021

Trotska V. Copyright and fundamental rights to freedom of the information, the press: EU judicial practice. The author in the article explores the issue of practical application of legal norms that cross two rights: copyright and the right to freedom of information, and press. The court decisions were analyzed in detail:«Spiegel Online GmbH v. Volker Bec» and others. Disputes were heard by German courts as well as by the Court of Justice of the EU (decision of July 29, 2019). The court's explanation of the application of European and German copyright law in the context of exceptions and limitations to these rights for informational purposes has been researched.The main questions were answered by the Court of Justice of the EU and the German Court has been considered:Was the use of the work a notification of current events?What is a citation of the work?Is a hyperlink to his work considered as citation?
How to find a balance between copyright and fundamental rights to freedom of the information and the press?Attention is drawn to the recommendations of the Court of Justice of the EU to the national court in finding a balance between the exclusive rights of the copyright subject, on the one hand, and the rights of users, on the other hand; taking into account all the circumstances of the case, based on fundamental rights are provided in the Charter of Fundamental Rights of the European Union, and the norms of copyright law.Resolving such disputes requires: take into account the character of the information; to decide whether the information is a notification of current events, even in cases where the event occurred much earlier, but at the time of the dispute considered as public interest; establish the purpose and scope of citation of the work, whether the citation goes beyond what is necessary to achieve the information goal; consider thatcitations can be made, via hyperlinking to the work.A comparison is made between the norms of the legislation of Ukraine on copyright about the free use of works and the corresponding the norms of the European and German legislation.Judicial decisions are interesting, and their consideration is useful, for several reasons.Firstly, the court provided detailed explanations on the conditions of free use of the works of the Media for information purposes.Secondly, recommendations are provided to ensure the balance of these rights.Third, the conditions under which the use of the works (their fragments) will be considered a citation by means of a hyperlink, are determined.Fourth, explanations of the norms of Directive 2001/29/EU of the European Parliament and of the Council on the harmonization of certain aspects of copyright and related rights in the information society, are provided.Therefore, familiarization with these cases and their analysis conducted by the author in the article will be useful for judges, lawyers, jurists, scholars and other stakeholders.
Application of Extreme Learning Machine in the Survival Analysis of Chronic Heart Failure Patients With High Percentage of Censored Survival Time
Authors: Yang Hong , Tian Jing , Meng Bingxia , Wang Ke , Zheng Chu , Liu Yanling , Yan Jingjing , Han Qinghua , Zhang Yanbo 
Published: October 2021

Objective: To explore the application of the Cox model based on extreme learning machine in the survival analysis of patients with chronic heart failure.Methods: The medical records of 5,279 inpatients diagnosed with chronic heart failure in two grade 3 and first-class hospitals in Taiyuan from 2014 to 2019 were collected; with death as the outcome and after the feature selection, the Lasso Cox, random survival forest (RSF), and the Cox model based on extreme learning machine (ELM Cox) were constructed for survival analysis and prediction; the prediction performance of the three models was explored based on simulated data with three censoring ratios of 25, 50, and 75%.Results: Simulation results showed that the prediction performance of the three models decreased with increasing censoring proportion, and the ELM Cox model performed best overall; the ELM Cox model constructed with 21 highly influential survival predictors screened from actual chronic heart failure data showed the best performance with C-index and Integrated Brier Score (IBS) of 0.775(0.755, 0.802) and 0.166(0.150, 0.182), respectively.Conclusion: The ELM Cox model showed good discrimination performance in the survival analysis of patients with chronic heart failure; it performs consistently for data with a high proportion of censored survival time; therefore, the model could help physicians identify patients at high risk of poor prognosis and target therapeutic measures to patients as early as possible.
Anthropogenic Inputs of Terrestrial Organic Matter Influence Carbon Loading and Methanogenesis in Coastal Baltic Sea Sediments
Authors: Jilbert Tom , Cowie Greg , Lintumäki Luukas , Jokinen Sami , Asmala Eero , Sun Xiaole , Mörth Carl-Magnus , Norkko Alf , Humborg Christoph 
Published: October 2021

Coastal regions globally have experienced widespread anthropogenic eutrophication in recent decades. Loading of autochthonous carbon to coastal sediments enhances the demand for electron acceptors for microbial remineralization, often leading to rearrangement of the sediment diagenetic zonation and potentially enhancing fluxes of methane and hydrogen sulfide from the seafloor. However, the role of anthropogenic inputs of terrestrial organic matter (OMterr.) in modulating diagenesis in coastal sediments is often overlooked, despite being of potential importance in regions of land-use and industrial change. Here we present a dated 4-m sediment and porewater geochemistry record from a eutrophic coastal location in the northern Baltic Sea, to investigate sources of recent carbon loading and their impact on modern diagenetic processes. Based on an end-member mixing model of sediment N/C ratios, we observe that a significant fraction of the late-20th century carbon loading at this location was contributed by OMterr.. Furthermore, analysis of lignin in this material shows depleted ratios of syringyl/vanillyl (S/V) and cinnamyl/vanillyl (C/V) phenols, indicative of enhanced inputs of woody gymnosperm tissue likely from forest industries. The rapid loading of organic matter from combined terrestrial and autochthonous sources during the late 20th century has stimulated methanogenesis in the sediment column, and shoaled the sulfate-methane transition zone (SMTZ) to a depth of 5–20 cm. Optical parameters of colored dissolved organic matter confirm that OMterr. is actively degrading in the methanogenic layer, implying a role for this material in diagenetic processes. Porewater CH4, SO42− δ13C-DIC, and ∑S2− data suggest that the modern SMTZ is a broad zone in which organoclastic sulfate reduction, methanogenesis and anaerobic oxidation of methane (AOM) co-occur. However, fluxes of CH4 and SO42− show that rates of these processes are similar to other marine locations with a comparably shallow SMTZ. We suggest that the shallow depth of the modern SMTZ is the principal reason for high observed diffusive and ebullitive methane fluxes from sediments in this area. Our results highlight that anthropogenic activities lead to multiple pathways of carbon loading to coastal sediments, and that forest industry impacts on sedimentation in the northern Baltic Sea may be more widespread than previously acknowledged.
Sustainability of Developed Self-Regulation by Means of Formative Assessment Among Young Adolescents: A Longitudinal Study
Authors: Beekman Kelly , Joosten-Ten Brinke Desirée , Boshuizen Els 
Published: October 2021

The present study examined the long-term impact of a formative assessment intervention in primary education on the development of students’ levels of self-regulation, motivation, and self-efficacy after their transition to secondary education. Participants in the study included 695 Dutch sixth graders from 17 schools. A longitudinal design with measurements on three time points was adopted. The first part of the study, consisting of a pretest, the intervention, and posttest, was conducted during the students’ last 7 months in primary education using two experimental conditions, with peer- and self-assessment, and a control condition. A follow-up took place 10 weeks later, after the summer break and at the commencement of the participants’ secondary education. Longitudinal multilevel analyses showed that the development of self-regulation and motivation is significantly positively associated with the formative self- and peer-assessment interventions and continues after the transition to secondary education. Results are discussed with regard to theoretical and practical consequences.
Clinical Characteristics and Management of Patients With McCune-Albright Syndrome With GH Excess and Precocious Puberty: A Case Series and Literature Review
Authors: Zhai Xiao , Duan Lian , Yao Yong , Xing Bing , Deng Kan , Wang Linjie , Feng Feng , Liang Zhiyong , You Hui , Yang Hongbo , Lu Lin , Chen Shi , Wang Renzhi , Pan Hui , Zhu Huijuan 
Published: October 2021

BackgroundMcCune-Albright syndrome is a rare disorder characterized by fibrous dysplasia, café au lait skin spots, and hyperfunctioning endocrinopathies. The coexistence of precocious puberty and growth hormone excess in McCune-Albright syndrome is rare. Both conditions can manifest as accelerated growth, and treatments can be more challenging for such patients. This study aimed to describe the clinical manifestations of combined GH excess and PP in the context of McCune-Albright syndrome and analyze the clinical features and treatments of these patients.MethodClinical data from 60 McCune-Albright syndrome patients from Peking Union Medical College Hospital were obtained. The demographic characteristics, growth hormone, insulin-like growth factor-1, prolactin, alkaline phosphatase, and sex hormone levels; growth velocity; and bone age data were obtained. The growth velocity Z-score, bone age over chronological age ratio, and predicted adult height Z-score were calculated before and after treatment. Published studies and case reports were systemically searched, and data on demographic, clinical, and biochemical characteristics and treatment outcomes were obtained.ResultsWe reviewed seven patients among 60 McCune-Albright syndrome patients at Peking Union Medical College Hospital (5 female) and 39 patients (25 female) from the published literature. Six of the seven patients from Peking Union Medical College Hospital and half of the patients from the published studies were pediatric patients. These patients had increased growth velocity Z-scores and bone age over chronological age ratios. After good control of both conditions, the growth velocity Z-score and bone age over chronological age ratio decreased significantly, and the predicted adult height Z-score increased. The final heights and predicted adult height Z-scores were not impaired in patients with gigantism. All the patients had craniofacial fibrous dysplasia associated with optic and otologic complications.ConclusionMcCune-Albright syndrome with growth hormone excess and precocious puberty is more common in girls. Patients have accelerated linear growth and advanced skeletal age, and early and good control of both conditions leads to a reduced growth velocity and stabilized bone age. The predicted adult and final heights are not negatively affected when growth hormone excess is diagnosed in pediatric patients.
Spatial Analysis of Incidence of Diagnosed Type 2 Diabetes Mellitus and Its Association With Obesity and Physical Inactivity
Authors: Wu Jinrong , Wang Yang , Xiao Xin , Shang Xianwen , He Mingguang , Zhang Lei 
Published: October 2021

ObjectivesTo investigate the spatial distribution of 10-year incidence of diagnosed type 2 diabetes mellitus (T2DM) and its association with obesity and physical inactivity at a reginal level breakdown.MethodsDemographic, behavioral, medical and pharmaceutical and diagnosed T2DM incidence data were collected from a cohort of 232,064 participants who were free of diabetes at enrolment in the 45 and Up Study, conducted in the state of New South Wales (NSW), Australia. We examined the geographical trend and correlation between obesity prevalence, physical inactivity rate and age-and-gender-adjusted cumulative incidence of T2DM, aggregated based on geographical regions.ResultThe T2DM incidence, prevalence of obesity and physical inactivity rate at baseline were 6.32%, 20.24%, and 18.7%, respectively. The spatial variation of T2DM incidence was significant (Moran’s I=0.52; p&lt;0.01), with the lowest incidence of 2.76% in Richmond Valley-Coastal and the highest of 12.27% in Mount Druitt. T2DM incidence was significantly correlated with the prevalence of obesity (Spearman r=0.62, p&lt;0.001), percentage of participants having five sessions of physical activities or less per week (r=0.79, p&lt;0.001) and percentage of participants walked to work (r=-0.44, p&lt;0.001). The geographical variations in obesity prevalence and physical inactivity rate resembled the geographical variation in the incidence of T2DM.ConclusionThe spatial distribution of T2DM incidence is significantly associated with the geographical prevalence of obesity and physical inactivity rate. Regional campaigns advocating the importance of physical activities in response to the alarming T2DM epidemic should be promoted.
Identification of Immune-Related Risk Characteristics and Prognostic Value of Immunophenotyping in TNBC
Authors: Yi Jiarong , Shuang Zeyu , Zhong Wenjing , Wu Haoming , Feng Jikun , Zouxu Xiazi , Huang Xinjian , Li Siqi , Wang Xi 
Published: October 2021

Background: Triple-negative breast cancer (TNBC) is not sensitive to targeted therapy with HER-2 monoclonal antibody and endocrine therapy due to lack of ER, PR, and HER-2 receptors. TNBC is a breast cancer subtype with the worst prognosis and the highest mortality rate compared with other subtypes.Materials and Methods: Breast cancer-related data were retrieved from The Cancer Genome Atlas (TCGA) database, and 116 cases of triple-negative breast cancer were identified from the data. GSE31519 dataset was retrieved from Gene Expression Omnibus (GEO) database, comprising a total of 68 cases with TNBC. Survival analysis was performed based on immune score, infiltration score and mutation score to explore differences in prognosis of different immune types. Analysis of differentially expressed genes was conducted and GSEA analysis based on these genes was conducted to explore the potential mechanism.Results: The findings showed that comprehensive immune typing is highly effective and accurate in assessing prognosis of TNBC patients. Analysis showed that MMP9, CXCL9, CXCL10, CXCL11 and CD7 are key genes that may affect immune typing of TNBC patients and play an important role in prediction of prognosis in TNBC patients.Conclusion: The current study presents an evaluation system based on immunophenotyping, which provides a more accurate prognostic evaluation tool for TNBC patients. Differentially expressed genes can be targeted to improve treatment of TNBC.