bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2: is there neuroinvasion?
Authors: McQuaid Conor , Brady Molly , Deane Rashid 
Published: July 2021

Abstract
Background
SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory distress syndrome, and a number of non-respiratory complications, particularly in older male patients with prior health conditions, such as obesity, diabetes and hypertension. These prior health conditions are associated with vascular dysfunction, and the CoV disease 2019 (COVID-19) complications include multiorgan failure and neurological problems. While the main route of entry into the body is inhalation, this virus has been found in many tissues, including the choroid plexus and meningeal vessels, and in neurons and CSF.

Main body
We reviewed SARS-CoV-2/COVID-19, ACE2 distribution and beneficial effects, the CNS vascular barriers, possible mechanisms by which the virus enters the brain, outlined prior health conditions (obesity, hypertension and diabetes), neurological COVID-19 manifestation and the aging cerebrovascualture. The overall aim is to provide the general reader with a breadth of information on this type of virus and the wide distribution of its main receptor so as to better understand the significance of neurological complications, uniqueness of the brain, and the pre-existing medical conditions that affect brain. The main issue is that there is no sound evidence for large flux of SARS-CoV-2 into brain, at present, compared to its invasion of the inhalation pathways.

Conclusions
While SARS-CoV-2 is detected in brains from severely infected patients, it is unclear on how it gets there. There is no sound evidence of SARS-CoV-2 flux into brain to significantly contribute to the overall outcomes once the respiratory system is invaded by the virus. The consensus, based on the normal route of infection and presence of SARS-CoV-2 in severely infected patients, is that the olfactory mucosa is a possible route into brain. Studies are needed to demonstrate flux of SARS-CoV-2 into brain, and its replication in the parenchyma to demonstrate neuroinvasion. It is possible that the neurological manifestations of COVID-19 are a consequence of mainly cardio-respiratory distress and multiorgan failure. Understanding potential SARS-CoV-2 neuroinvasion pathways could help to better define the non-respiratory neurological manifestation of COVID-19.
Expression of SOX2 and OCT4 in odontogenic cysts and tumors
Authors: Phattarataratip Ekarat , Panitkul Tarit , Khodkaew Watunyoo , Anupuntanun Pattarapong , Jaroonvechatam Jirapat , Pitarangsikul Sirawit 
Published: July 2021

Abstract
Background
Aberrant expression of stem cell markers has been observed in several types of neoplasms. This trait attributes to the acquired stem-like property of tumor cells and can impact patient prognosis. The objective of this study was to comparatively analyze the expression and significance of SOX2 and OCT4 in various types of odontogenic cysts and tumors.

Methods
Fifty-five cases of odontogenic cysts and tumors, including 15 ameloblastomas (AM), 5 adenomatoid odontogenic tumors (AOT), 5 ameloblastic fibromas (AF), 5 calcifying odontogenic cysts (COC), 10 dentigerous cysts (DC) and 15 odontogenic keratocysts (OKC) were investigated for the expression of SOX2 and OCT4 immunohistochemically.

Results
Most OKCs (86.7 %) and all AFs expressed SOX2 in more than 50 % of epithelial cells. Its immunoreactivity was moderate-to-strong in all epithelial cell types in both lesions. In contrast, SOX2 expression was undetectable in AOTs and limited to the ameloblast-like cells in a minority of AM and COC cases. Most DCs showed positive staining in less than 25 % of cystic epithelium. Significantly greater SOX2 expression was noted in OKC compared with DC or AM, and in AF compared with COC or AOT. OCT4 rarely expressed in odontogenic lesions with the immunoreactivity being mild and present exclusively in OKCs.

Conclusions
SOX2 is differentially expressed in odontogenic cysts and tumors. This could be related to their diverse cells of origin or stages of histogenesis. The overexpression of SOX2 and OCT4 in OKC indicates the acquired stem-like property. Future studies should investigate whether the overexpression of OCT4 and SOX2 contributes to the aggressive behaviors of the tumors.
Predictors of osteoradionecrosis following irradiated tooth extraction
Authors: Khoo Szu Ching , Nabil Syed , Fauzi Azizah Ahmad , Yunus Siti Salmiah Mohd , Ngeow Wei Cheong , Ramli Roszalina 
Published: July 2021

Abstract
Background
Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which were associated with a dental extraction post radiotherapy.

Methods
A retrospective analysis of medical records and dental panoramic tomogram (DPT) of patients with a history of head and neck radiotherapy who underwent dental extraction between August 2005 to October 2019 was conducted.

Results
Seventy-three patients fulfilled the inclusion criteria. 16 (21.9%) had ORN post dental extraction and 389 teeth were extracted. 33 sockets (8.5%) developed ORN. Univariate analyses showed significant associations with ORN for the following factors: tooth type, tooth pathology, surgical procedure, primary closure, target volume, total dose, timing of extraction post radiotherapy, bony changes at extraction site and visibility of lower and upper cortical line of mandibular canal. Using multivariate analysis, the odds of developing an ORN from a surgical procedure was 6.50 (CI 1.37–30.91, p = 0.02). Dental extraction of more than 5 years after radiotherapy and invisible upper cortical line of mandibular canal on the DPT have the odds of 0.06 (CI 0.01–0.25, p < 0.001) and 9.47 (CI 1.61–55.88, p = 0.01), respectively.

Conclusion
Extraction more than 5 years after radiotherapy, surgical removal procedure and invisible upper cortical line of mandibular canal on the DPT were the predictors of ORN.
Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis
Authors: Ling Ryan Ruiyang , Ramanathan Kollengode , Poon Wynne Hsing , Tan Chuen Seng , Brechot Nicolas , Brodie Daniel , Combes Alain , MacLaren Graeme 
Published: July 2021

Abstract
Background
While recommended by international societal guidelines in the paediatric population, the use of venoarterial extracorporeal membrane oxygenation (VA ECMO) as mechanical circulatory support for refractory septic shock in adults is controversial. We aimed to characterise the outcomes of adults with septic shock requiring VA ECMO, and identify factors associated with survival.

Methods
We searched Pubmed, Embase, Scopus and Cochrane databases from inception until 1st June 2021, and included all relevant publications reporting on > 5 adult patients requiring VA ECMO for septic shock. Study quality and certainty in evidence were assessed using the appropriate Joanna Briggs Institute checklist, and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach, respectively. The primary outcome was survival to hospital discharge, and secondary outcomes included intensive care unit length of stay, duration of ECMO support, complications while on ECMO, and sources of sepsis. Random-effects meta-analysis (DerSimonian and Laird) were conducted.

Data synthesis
We included 14 observational studies with 468 patients in the meta-analysis. Pooled survival was 36.4% (95% confidence interval [CI]: 23.6%–50.1%). Survival among patients with left ventricular ejection fraction (LVEF) < 20% (62.0%, 95%-CI: 51.6%–72.0%) was significantly higher than those with LVEF > 35% (32.1%, 95%-CI: 8.69%–60.7%, p = 0.05). Survival reported in studies from Asia (19.5%, 95%-CI: 13.0%–26.8%) was notably lower than those from Europe (61.0%, 95%-CI: 48.4%–73.0%) and North America (45.5%, 95%-CI: 16.7%–75.8%). GRADE assessment indicated high certainty of evidence for pooled survival.

Conclusions
When treated with VA ECMO, the majority of patients with septic shock and severe sepsis-induced myocardial depression survive. However, VA ECMO has poor outcomes in adults with septic shock without severe left ventricular depression. VA ECMO may be a viable treatment option in carefully selected adult patients with refractory septic shock.
Magnetic COFs as satisfactory support for lipase immobilization and recovery to effectively achieve the production of biodiesel by maintenance of enzyme activity
Authors: Zhou Zi-Wen , Cai Chun-Xian , Xing Xiu , Li Jun , Hu Zu-E. , Xie Zong-Bo , Wang Na , Yu Xiao-Qi 
Published: July 2021

Abstract
Background
Production of biodiesel from renewable sources such as inedible vegetable oils by enzymatic catalysis has been a hotspot but remains a challenge on the efficient use of an enzyme. COFs (Covalent Organic Frameworks) with large surface area and porosity can be applied as ideal support to avoid aggregation of lipase and methanol. However, the naturally low density limits its application. In this work, we reported a facile synthesis of core–shell magnetic COF composite (Fe3O4@COF-OMe) to immobilize RML (Rhizomucor miehei lipase), to achieve its utilization in biodiesel production.

Result
This strategy gives extrinsic magnetic property, and the magnetic COFs is much heavier and could disperse in water medium well, facilitating the attachment with the enzyme. The resultant biocomposite exhibited an excellent capacity of RML due to its high surface area and fast response to the external magnetic field, as well as good chemical stability. The core–shell magnetic COF-OMe structure not only achieved highly efficient immobilization and recovery processes but also maintained the activity of lipase to a great extent. RML@Fe3O4@COF-OMe performed well in practical applications, while free lipase did not. The biocomposite successfully achieved the production of biodiesel from Jatropha curcas Oil with a yield of about 70% in the optimized conditions.

Conclusion
Magnetic COFs (Fe3O4@COF-OMe) for RML immobilization greatly improved catalytic performance in template reaction and biodiesel preparation. The magneticity makes it easily recovered and separated from the system. This first successful attempt of COFs-based immobilized enzyme broadened the prospect of biodiesel production by COFs with some inspiration.
Repeated intracranial empyema following cranioplasty in a patient with atopic dermatitis: a case report
Authors: Kubota Shuhei , Nemoto Masaaki , Sakaeyama Yuki , Nakada Chie , Mikai Masataka , Fuchinoue Yutaka , Kondo Kosuke , Harada Naoyuki , Sugo Nobuo 
Published: July 2021

Abstract
Background
Atopic dermatitis is a chronic inflammatory skin disease associated with pruritus. Skin affected by atopic dermatitis not only shows a high percentage of Staphylococcus aureus colonization, but corneal barrier dysfunction is also known to occur. It is considered a risk factor for bacterial infections in various areas of the body. However, the relationship between atopic dermatitis and bacterial infection following neurological surgery has not yet been reported. Here, we present a case of atopic dermatitis in which the surgical site became infected twice and finally resolved only after the atopic dermatitis was treated.

Case presentation
A 50-year-old Japanese woman with atopic dermatitis underwent cerebral aneurysm clipping to prevent impending rupture. Postoperatively, she developed repeated epidural empyema following titanium cranioplasty. As a result of atopic dermatitis treatment with oral antiallergy medicines and external heparinoids, postoperative infection was suppressed by using an absorbable plastic plate for cranioplasty. The patient’s postoperative course was uneventful for 16 months.

Conclusions
Atopic dermatitis is likely to cause surgical-site infection in neurosurgical procedures, and the use of a metal implant could promote the development of surgical-site infection in patients with dermatitis.
Klüver–Bucy syndrome secondary to a nondominant middle cerebral artery ischemic stroke: a case report and review of the literature
Authors: Al-Attas Alawi Aqel , Aldayel Abdulrahman Yousef , Aloufi Tareq Hamad , Biary Nabil 
Published: July 2021

AbstractBackgroundKlüver–Bucy syndrome is a rare and complex neurobehavioral cluster that occurs in humans and results from a temporal lobe lesion. It can be associated with a variety of causes. Stroke is a rarely reported cause of this syndrome.Case presentationIn this report, we present the case of a 68-year-old Saudi male who developed Klüver–Bucy syndrome subsequent to a nondominant middle cerebral artery ischemic stroke involving right temporal lobe. The patient manifested most of the Klüver–Bucy syndrome clinical features, including hypersexuality, hyperphagia, hyperorality, and visual hypermetamorphosis (excessive tendency to react to every visual stimulation with a tendency to touch every such stimulus). These neurobehavioral manifestations improved after he was started on treatment.ConclusionsThe clinical course, anatomical association relying on pathophysiology, and potential treatment have all been deliberated in regard to the rare occurrence of Klüver–Bucy syndrome resulting from temporal lobe pathology.
Application of chaotic encryption algorithm based on variable parameters in RFID security
Authors: Guo Yi , Yang Jianfang , Liu Baolong 
Published: July 2021

AbstractIn the development of the Internet of Things technology, RFID technology plays a very important role in the application of the Internet of Things. However, due to the safety problems caused by the non-contact sensing of the RFID system, the further development of RFID technology in the application is largely hindered. In recent years, chaotic encryption has been applied in the field of cryptography by virtue of its unique characteristics, and it has received more and more attention in the security of RFID data transmission. Using the same key for encryption and decryption operations is a lightweight encryption algorithm. However, there are various problems in the application process of chaotic encryption: (1) nonlinear dynamic characteristics degradation and short-cycle cycle problems will occur under the influence of computer limited accuracy; (2) numerical conversion operations are required during application, to a certain extent It will affect the randomness of the iterative sequence; (3) During the iterative process, the iterative sequence cannot be spread over the entire value interval, and the randomness is poor. This paper proposes an improved segmented Logistic mapping encryption algorithm, uses the m-sequence to perturb initial value and sets a fixed step to change the control parameter value to generate a chaotic key stream sequence, and applies it to the RFID system data transmission security mechanism to encrypt the data. Experimental simulation and performance analysis show that the iterated chaotic sequence has good random distribution characteristics, unpredictability, and traversability. Compared to the previous improvement, the key space is increased to reach the size of 1024 space and can meet the security needs, which improve RFID data security and can effectively avoid various security problems.
Spectrum sensing based on adaptive sampling of received signal
Authors: Miao Jiawu , Tan Youheng , Zhang Yangying , Li Yuebo , Mu Junsheng , Jing Xiaojun 
Published: July 2021

AbstractSpectrum sensing (SS) has been heatedly discussed due to its capacity to discover the idle registered spectrum bands, which effectively alleviates the shortage of spectrum by spectrum reuse. Energy detector (ED) is widely accepted for SS as its complexity is very low. In this paper, an adaptive sampling scheme is proposed to improve the sensing performance of ED, where the sampling point of the received signal is adaptively adjusted with the environment signal-to-noise ratio (SNR). When SNR decreases, the sensing performance can be maintained and even improved by the rise of the sampling point. When SNR increases, the improved ED is considered for idle spectrum detection. The SNR is evaluated based on the joint of convolutional neural network (CNN) and long short-term memory (LSTM) network. Both theoretical derivations and simulation experiments validate the effectiveness of the proposed scheme.
Two-sided fractional quaternion Fourier transform and its application
Authors: Li Zunfeng , Shi Haipan , Qiao Yuying 
Published: July 2021

AbstractIn this paper, we introduce the two-sided fractional quaternion Fourier transform (FrQFT) and give some properties of it. The main results of this paper are divided into three parts. Firstly we give a definition of the FrQFT. Secondly based on properties of the two-sided QFT, we study the relationship between the two-sided QFT and the two-sided FrQFT, and give some differential properties of the two-sided FrQFT and the Parseval identity. Finally, we give an example to illustrate the application of the two-sided FrQFT and its inverse transform in solving partial differential equations.
Residual effects of corncob biochar on tropical degraded soil in central Uganda
Authors: Apori Samuel Obeng , Byalebeka John , Muli Gideon Kalii 
Published: July 2021

Abstract
Background
The residual effects of biochar are yet to receive adequate research attention in Sub-Saharan Africa despite the assumption that the positive effect of biochar may last longer on degraded tropical soil. Hence a field experiment was conducted to assess the residual effects of biochar, farmyard compost and NPK fertilizer applications on a Ferralsol in central Uganda. The field used for the study was previously used to conduct experiments for two seasons to assess the contribution of corncob biochar to the chemical properties of this highly degraded tropical soil.

Result
The co-applied biochar with compost and NPK fertilizer significantly (p < 0.05) increased some soil chemical properties such as soil pH, available phosphorus, soil organic carbon, and potassium than the control. The co-applied biochar with compost also significantly (p < 0.05) increased the soil pH and effective cation exchange capacity compared to the solely applied compost and NPK fertilizer. Collard plant height, canopy, stem girth, number of leaves, leaf length, and total biomass were significantly (p < 0.05) higher in the biochar amended soil than the unamended soil.

Conclusion
It was concluded that the addition of biochar with compost and NPK fertilizer had a significant residual effect on degraded tropical soils than solely applied NPK and compost.
Impact of gamma irradiation pretreatment on biochemical and molecular responses of potato growing under salt stress
Authors: Mohamed Elhamahmy Ali , Osama Elsadany , Manal Eid , Samah Abdelazeem , Salah Gerish , Hazem Kalaji M. , Jacek Wróbel , Nabil Elsheery 
Published: July 2021

Abstract
Background
Previous literatures revealed that gamma rays have an increasing effect on salt tolerance in different plants. In vitro experiment was conducted to study the effect of gamma rays (20 Gray) on salt tolerance of four potato cultivars (Lady Rosetta, Diamante, Gold, and Santana).

Results
Gamma-treated Santana plantlets were more tolerant to salinity as compared to other cultivars. It showed a significant increment of fresh weight (250% over the untreated). Gamma-treated plantlets of Lady Rosetta, Diamante, and Gold showed higher activity of peroxidase (POD) and polyphenol oxidase (PPO). Isoenzymes analysis showed an absence of POD 3, 4, and 5 in Gold plantlets. The dye of most PODs and PPOs bands were denser (more active) in gamma-treated plantlets of Santana as compared to other cultivars. Both gamma-treated and untreated plantlets showed the absence of PPO1 in Lady Rosetta and Diamante, and PPO 3, 4, and 5 in Gold plantlets. Genetic marker analysis using ISSR with six different primers showed obvious unique negative and positive bands with different base pairs in mutant plantlets as compared to the control, according to primer sequence and potato genotype. The 14A primer was an efficient genetic marker between mutated and unmutated potato genotypes. Santana had a unique fingerprint in the 1430-pb site, which can be a selectable marker for the cultivar. An increment in genetic distance between Gold cultivar and others proved that the mutation was induced because of gamma rays.

Conclusion
We assume that irradiation of potato callus by 20-Gy gamma rays is an effective process for inducing salt resistance. However, this finding should be verified under field conditions.

Graphic Abstract
Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs
Authors: Yang Yifang , Wu Junshu , Wu Defu , Wei Qi , Zhong Tan , Yang Jun , Yang Xiaowei , Zeng Meizhen , Zhong Xingwu 
Published: July 2021

Abstract
Background
The use of ocular hypotensive drugs has been reported to attenuate myopia progression. This study explores whether brimonidine can slow myopia progression in the guinea pig form-deprivation (FD) model.

Methods
Three-week-old pigmented male guinea pigs (Cavia porcellus) underwent monocular FD and were treated with 3 different methods of brimonidine administration (eye drops, subconjunctival or intravitreal injections). Four different concentrations of brimonidine were tested for intravitreal injection (2 μg/μL, 4 μg/μL, 20 μg/μL, 40 μg/μL). All treatments continued for a period of 21 days. Tonometry, retinoscopy, and A-scan ultrasonography were used to monitor intraocular pressure (IOP), refractive error and axial length (AL), respectively. On day 21, guinea pigs were sacrificed for RNA sequencing (RNA-seq) to screen for associated transcriptomic changes.

Results
The myopia model was successfully established in FD animals (control eye vs. FD eye, respectively: refraction at day 20, 0.97 ± 0.18 D vs. − 0.13 ± 0.38 D, F = 6.921, P = 0.02; AL difference between day 0 and day 21, 0.29 ± 0.04 mm vs. 0.45 ± 0.03 mm, F = 11.655, P = 0.004). Among the 3 different brimonidine administration methods, intravitreal injection was the most effective in slowing myopia progression, and 4 μg/μL was the most effective among the four different concentrations of brimonidine intravitreal injection tested. The AL and the refraction of the brimonidine intravitreal injection group was significantly shorter or more hyperopic than those of other 2 groups. Four μg/μL produced the smallest difference in AL and spherical equivalent difference values. FD treatment significantly increased the IOP. IOP was significantly lower at 1 day after intravitreal injections which was the lowest in FD eye of intravitreal injection of brimonidine. At day 21, gene expression analyses using RNA-seq showed upregulation of Col1a1 and Mmp2 expression levels by intravitreal brimonidine.

Conclusions
Among the 3 different administration methods, intravitreal injection of brimonidine was the most effective in slowing myopia progression in the FD guinea pig model. Intravitreal brimonidine at 4 μg/μL significantly reduced the development of FD myopia in guinea pigs. Expression levels of the Col1a1 and Mmp2 genes were significantly increased in the retinal tissues of the FD-Inj-Br group.