bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relasi Self-Esteem dan Body Image dalam Terpaan Media Sosial Instagram
Authors: Martanatasha Michelia , Primadini Intan 
Published: June 2021

Penelitian ini dilatarbelakangi oleh fenomena ‘detoks media sosial’ yang sedang dilakukan oleh masyarakat untuk menghindari dampak negatif dari media sosial. Tingginya pengguna aktif Instagram di Indonesia, yaitu 80 % dari total 150 juta pengguna aktif media sosial, menyebabkan masyarakat rentan terkena gangguan kesehatan mental yang ditimbulkan dari penggunaan media sosial Instagram secara berlebih. Gangguan yang ditimbulkan adalah gangguan pada citra tubuh dan pada kepercayaan diri. Tujuan dari penelitian ini adalah untuk mengetahui apakah terdapat pengaruh antara tingkat terpaan media sosial Instagram terhadap tingkat self-esteem melalui tingkat persepsi mengenai body image. Penelitian ini menggunakan teori perbandingan sosial dengan konsep terpaan media, body image, dan self-esteem. Metodologi penelitian ini adalah kuantitatif dengan sifat penelitian eksplanatif. Responden penelitian ini adalah 400 responden dengan menggunakan teknik non probability purposive sampling dengan penyebaran kuesioner secara online. Teknik analisis data yang digunakan adalah uji analisis jalur untuk mengetahui pengaruh tidak langsung antara tiga variabel. Hasil penelitian menunjukkan bahwa terdapat pengaruh tidak langsung antara ketiga variabel yang digunakan. Selain itu, terdapat pengaruh yang signifikan antara tingkat terpaan media sosial Instagram terhadap tingkat persepsi mengenai body image sebesar 7,6% dan tingkat persepsi mengenai body image terhadap tingkat self-esteem sebesar 68,3%. Akan tetapi, antara terpaan media sosial Instagram dengan tingkat self-esteem tidak memiliki pengaruh yang signifikan. Hasil ini membuktikan bahwa penggunaan media sosial Instagram dapat memengaruhi citra tubuh yang dimiliki oleh seseorang yang juga memengaruhi self-esteem.
Kata Kunci: Body image, Instagram, Media Sosial, Self-esteem, Teori Perbandingan Sosial
Antibacterial properties in-vitro of Mexican serviceberry extracts against dental biofilm species
Authors: Salinas-Peña Erika-Alejandra , Mendoza-Rodríguez Martha , Velázquez-González Claudia , Medina-Solis Carlo Eduardo , Pontigo-Loyola América Patricia , Márquez-Corona María de Lourdes , Rodríguez-Hernández Adriana-Patricia , Ximénez-Fyvie Laurie-Ann 
Published: June 2021

BACKGROUND: The Mexican serviceberry, Malacomeles denticulata, have been used as a successful oral therapy by Mexican communities without enough scientific support. OBJECTIVE: To evaluate the M. denticulata extracts with selective antibacterial properties over dental biofilm bacteria. METHODS: Fruit, Leaf, and Stem of M. denticulata extracts were evaluated with micro-broth dilution method using ATCC bacteria. OD600 values had compared against each positive control ( T-student-test). Anaerobically viability had confirmed by Colony-Forming-Units. Thin-Layer-Chromatography was used to identify the number of compounds and phytochemicals to identify secondary metabolites of the selected extracts. RESULTS: Streptococcus mutans showed Minimum-Bactericidal-Concentrations_(MBC) at 30 mg/mL to Fruit, Leaf, and Stem extracts. Periodontal-pathogens Aggregatibacter actinomycetemcomitans serotype b_(MBC = 30 mg/mL_NS); Fusobacterium nucleatum subsp. nucleatum_(MBC = 30 mg/mL_ p<0.05); Parvimonas micra_(MBC = 15 mg/mL_NS); Porphyromonas gingivalis_(MBC = 30 mg/mL_NS); and Prevotella intermedia_(MBC = 3.75 mg/mL_NS) presented higher sensitivity to Leaf-Methanol, than the primary colonizers. Phytochemicals showed positive results to anthraquinones, coumarins, flavonoids, saponins, saponins steroids/triterpenoids, steroids/triterpenes, and tannins/phenols. CONCLUSION: We suggest the natural extracts of fruit and leaf of the Mexican serviceberry for the preventive use over the oral cariogenic or periodontal biofilm species, by their selective antibacterial properties against pathogenic species evaluated in-vitro, and due to the presence of antibacterial secondary metabolites identified as flavonoids and saponins of M. denticulata leaf extracts.
IncobotulinumtoxinA for the treatment of lower-limb spasticity in children and adolescents with cerebral palsy: A phase 3 study1
Authors: Heinen Florian , Kanovský Petr , Schroeder A. Sebastian , Chambers Henry G. , Dabrowski Edward , Geister Thorin L. , Hanschmann Angelika , Martinez-Torres Francisco J. , Pulte Irena , Banach Marta , Gaebler-Spira Deborah 
Published: June 2021

PURPOSE: Investigate the efficacy and safety of multipattern incobotulinumtoxinA injections in children/adolescents with lower-limb cerebral palsy (CP)-related spasticity. METHODS: Phase 3 double-blind study in children/adolescents (Gross Motor Function Classification System – Expanded and Revised I–V) with unilateral or bilateral spastic CP and Ashworth Scale (AS) plantar flexor (PF) scores ? 2 randomized (1:1:2) to incobotulinumtoxinA (4, 12, 16 U/kg, maximum 100, 300, 400 U, respectively) for two 12- to 36-week injection cycles. Two clinical patterns were treated. Pes equinus (bilateral or unilateral) was mandatory; if unilateral, treatment included flexed knee or adducted thigh. Endpoints: Primary: AS-PF change from baseline to 4 weeks; Coprimary: investigator-rated Global Impression of Change Scale (GICS)-PF at 4 weeks; Secondary: investigator’s, patient’s, and parent’s/caregiver’s GICS, Gross Motor Function Measure-66 (GMFM-66). RESULTS: Among 311 patients, AS-PF and AS scores in all treated clinical patterns improved from baseline to 4-weeks post-injection and cumulatively across injection cycles. GICS-PF and GICS scores confirmed global spasticity improvements. GMFM-66 scores indicated better motor function. No significant differences between doses were evident. Treatment was well-tolerated, with no unexpected treatment-related adverse events or neutralising antibody development. CONCLUSION: Children/adolescents with lower-limb spasticity experienced multipattern benefits from incobotulinumtoxinA, which was safe and well-tolerated in doses up to 16 U/kg, maximum 400 U.
Docencia universitaria del siglo XXI
Authors: Reyes Castro María Aída 
Published: June 2021

En el siglo XXI, las funciones de docencia, investigación científica y difusión de la cultura; así como la tutoría, la administración y la extensión de los servicios, desafían a los académicos universitarios en cuanto que, demandan formas de actuación responsables, equitativas, flexibles, eficientes, eficaces, pertinentes, actualizadas permanentemente, y alta-mente especializadas.
Educación en valores, ética y moral
Authors: Pacheco González MCSyH María de Lourdes 
Published: June 2021

La educación moral es algo que se lleva a cabo desde el hogar, ya que en toda sociedad se busca conformar en sus miembros un cierto tipo de conducta que permita no solamente la convivencia entre éstos sino que tal convivencia sea lo más sana posible y que permita que todos construyan “el modo como se quiere ser y el modo como se quiere vivir” y entonces alcancen la felicidad. Esta práctica lleva implícitos los valores, es la educación informal, que no tiene nombre ni apellido.
Aprendizaje situado,una alternativa para responder a los retos educativos de hoy
Authors: Gómez Márquez Luis Gerardo 
Published: June 2021

Para realizar acciones en el área de educación es imprescindible conocer la realidad en la que ésta se desarrolla, o habrá de desarrollarse. El aprendizaje situado es aquella metodología que pretende unir la educación con la realidad, ya que permite al estudiante aprehender de esta realidad en su entorno para entender y afirmar sus conocimientos. Por tanto, a partir de esta afirmación, la mayor parte de los planes y programas de estudio suelen estar descontextualizados, pues son realizados en su mayoría por individuos que no conocen las realidades en las que se pretende llevar a cabo su aplicación.
Quality and shelf-life extension of refrigerated (4°C) Spotted snakehead (Channa punctata) using γ-radiation and food-grade preservative
Authors: Mou Efat Ara , Haque Md Enamul , Hossain Arzina , Islam Mahfuza , Munshi Md Kamruzzaman , Asaduzzaman Khandoker , Huque Roksana 
Published: June 2021

Investigations were carried out to evaluate the effect of gamma radiation (1.0 and 1.5 kGy) and food-grade preservative (2% potassium sorbate) on the shelf-life of refrigerated (4°C) Spotted snakehead, Channa punctata (Bloch, 1793). Quality assessments were evaluated by sensory (OS), chemical (TV), microbial (TBC and TCC) analyses. Based on control panel, OS was shown to be gradually decreased with the storage time. Irradiated and potassium sorbate treated samples were found acceptable (edible) up to 28 and 21 days, respectively of storage period. TV were lower in irradiated samples with dose of 1.5 kGy compared to other samples. Though microbial load of each of the irradiated samples were within the acceptable limits up to 28 days but 1.5 kGy dose was found more effective. Gamma radiation in combination with good refrigeration could be most effective treatment for the shelf-life extension and microbiological quality improvement for snakehead preservation. Moreover, this preservation technique may be applicable for other fish species to enhance food safety for public health issues.
Jahangirnagar University J. Biol. Sci. 9(1 & 2): 1-12, 2020 (June & December)
Agronomic biofortification of rice and wheat with zinc: A metanalytical study
Authors: Sordi Elisangela , Novakowiski Jaqueline Huzar , Rebesquini Renata , Benedetti Tatiana , Carvalho Ivan Ricardo , Lautenchleger Francine , Bortoluzzi Edson Campanhola 
Published: June 2021

A diet based on cereals may lack essential mineral elements, among them zinc. The provision of this element in diets can be via supplements, food fortifiers or agronomic biofortification (AB), a practice adopted on a farmer scale. It was carried out different studies in countries with specific local conditions. The meta-analysis allows combining quantitative results from different studies, providing a synthesis of results with high reliability. The objective of this work was to analyze the response of rice (Oryza spp.) and wheat (Triticum spp.) to fertilization with zinc in terms of grain yield and accumulation of this nutrient in the grain. We carried out a systematic review where 16 scientific articles from the last five years were selected, and 179 studies fitted the established criteria. The effect size for Zn application via leaf or soil in rice and wheat compared to the control was calculated using the natural logarithm (lnR) between the ratio of the treatment group and the control group for both variables. Agronomic biofortification with Zn increases grain yield (7%) and zinc content in grains (53%). These results depend on plant species and the fertilization way (via the soil or foliar spray). Agronomic Biofortification may be a valuable strategy to combat malnutrition and guarantee food sovereignty.
Nogueira-pecã em sistema agroflorestal
Authors: Bilharva Maurício Gonçalves , Souza Rafaela Schmidt de , De Marco Rudinei , Lúcio Priscila da Silva , Martins Carlos Roberto , Cardoso Joel Henrique , Malgarim Marcelo Barbosa 
Published: June 2021

Os sistemas agroflorestais biodiversos são uma estratégia de manejo do solo que busca promover interações benéficas entre componentes bióticos e abióticos. A nogueira-pecã é uma espécie arbórea de ciclo longo e de grande porte, que influenciará de maneira decisiva os sistemas que ela integra. O objetivo deste trabalho é estabelecer padrões de comportamento das cultivares de nogueira-pecã dentro do sistema agroflorestal. Neste experimento realizado entre 2015 e 2017, a cultivar foi o fator de variação avaliado, sendo considerados quatro tratamentos: ‘Barton’, ‘Cape Fear’, ‘Desirable’ e ‘Shawnee’. As variáveis analisadas foram: altura e diâmetro das plantas; número de gemas por ramo; número de ramos; diâmetro e comprimento de ramo e números de folhas por ramo; área foliar; número de folíolos, peso fresco e seco; número de racimos e flores; inflorescências e ataque de formiga. Com relação ao comportamento reprodutivo, a cultivar Barton apresentou uma dicogamia do tipo protândrica, ‘Cape Fear’ oscilou o comportamento, demonstrando-se protogínica na primeira safra e protândrica na seguinte. ‘Barton’ e ‘Cape Fear’ demonstraram melhor desempenho reprodutivo do que ‘Desirable’ e ‘Shawnee’ em sistemas agroflorestais, porém, requer-se estudos que incluam a fase reprodutiva e considere outras cultivares.
The Vaginal Microbial Signatures of Preterm Birth Delivery in Indian Women
Authors: Kumar Shakti , Kumari Naina , Talukdar Daizee , Kothidar Akansha , Sarkar Mousumi , Mehta Ojasvi , Kshetrapal Pallavi , Wadhwa Nitya , Thiruvengadam Ramachandran , Desiraju Bapu Koundinya , Nair G. Balakrish , Bhatnagar Shinjini , Mukherjee Souvik , Das Bhabatosh ,   GARBH-Ini Study Group
Published: June 2021

BackgroundThe incidence of preterm birth (PTB) in India is around 13%. Specific bacterial communities or individual taxon living in the vaginal milieu of pregnant women is a potential risk factor for PTB and may play an important role in its pathophysiology. Besides, bacterial taxa associated with PTB vary across populations.ObjectiveConduct a comparative analysis of vaginal microbiome composition and microbial genomic repertoires of women who enrolled in the Interdisciplinary Group for Advanced Research on Birth Outcomes – A DBT India Initiative (GARBH-Ini) pregnancy cohort to identify bacterial taxa associated with term birth (TB) and PTB in Indian women.MethodsVaginal swabs were collected during all three trimesters from 38 pregnant Indian women who delivered spontaneous term (n=20) and preterm (n=18) neonates. Paired-end sequencing of V3-V4 region of 16S rRNA gene was performed using the metagenomic DNA isolated from vaginal swabs (n=115). Whole genome sequencing of bacterial species associated with birth outcomes was carried out by shotgun method. Lactobacillus species were grown anaerobically in the De Man, Rogosa and Sharpe (MRS) agar culture medium for isolation of genomic DNA and whole genome sequencing.ResultsVaginal microbiome of both term and preterm samples reveals similar alpha diversity indices. However, significantly higher abundance of Lactobacillus iners (p-value All_Trimesters&lt;0.02), Megasphaera sp (p-value1st_Trimester &lt;0.05), Gardnerella vaginalis (p-value2nd_Trimester= 0.01) and Sneathia sanguinegens (p-value2nd_Trimester &lt;0.0001) were identified in preterm samples whereas higher abundance of L. gasseri (p-value3rd_Trimester =0.010) was observed in term samples by Wilcoxon rank-sum test. The relative abundance of L. iners, and Megasphaera sp. were found to be significantly different over time between term and preterm mothers. Analyses of the representative genomes of L. crispatus and L. gasseri indicate presence of secretory transcriptional regulator and several ribosomally synthesized antimicrobial peptides correlated with anti-inflammatory condition in the vagina. These findings indicate protective role of L. crispatus and L. gasseri in reducing the risk of PTB.ConclusionOur findings indicate that the dominance of specific Lactobacillus species and few other facultative anaerobes are associated with birth outcomes.
Case Report: Disappearance of Coronary Anastomotic Aneurysm by Steroid Therapy in Takayasu Arteritis: Pseudorepair of Pseudoaneurysm?
Authors: Naraoka Shuichi , Uchiyama Hiroki , Yano Toshiyuki , Mikami Takuma , Harada Ryo , Kuroda Yosuke , Toda Yuki , Muranaka Atsuko , Sugawara Taro , Hasegawa Tadashi , Miura Tetsuji , Kawaharada Nobuyoshi 
Published: June 2021

Background: Takayasu arteritis (TA) is a large vessel vasculitis of unknown etiology characterized by chronic inflammatory changes of the aorta and its major branches. Complications such as anastomotic aneurysm and valve detachment have been reported in active TA patients who received aortic valve replacement and graft replacement of aorta.Case Summary:A 61-year-old man with a history of emergency aortic valve replacement and patch closure of the noncoronary sinus of Valsalva due to acute heart failure induced by acute aortic regurgitation and ruptured sinus of Valsalva 4 years ago was referred for exertional dyspnea. Dilatation of the sinus of Valsalva together with protrusion of the right sinus of Valsalva and ostial stenosis of the left coronary artery were newly found by computed tomography (CT). A Bentall operation with concomitant coronary artery bypass grafting was successfully performed with a composite graft. Diagnosis of TA was made on the basis of histological analyses of the resected sinus of Valsalva, though other arterial manifestations were not detected by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography. Three months later, a follow-up study revealed left coronary ostial pseudoaneurysm at the anastomotic site together with strong 18F-FDG uptake, leading to commencement of steroid therapy. Eight months later, disappearance of left coronary ostial pseudoaneurysm was found by a follow-up CT scan.Conclusion: This is a rare TA case in whom spontaneous resolution of coronary anastomotic aneurysm by steroid therapy was found without reconstructive surgery.
Serum Anti-Müllerian Hormone Levels Were Negatively Associated With Body Fat Percentage in PCOS Patients
Authors: Luo Er , Zhang Jinxiao , Song Jiahui , Feng Di , Meng Yaxin , Jiang Hongyu , Li Da , Fang Yuanyuan 
Published: June 2021

BackgroundObesity is a state of excess body fat accumulation, and appears to be closely associated with polycystic ovary syndrome (PCOS). Notably, plausible biological pathways through which obesity can regulate anti-Müllerian hormone (AMH) production have been proposed, and women with PCOS characteristically have an increased AMH level. Body fat accumulation can be described by body fat percentage (BFP). However, the relationship between BFP and AMH still remains unclear.Materials and MethodsA total of 87 controls and 156 PCOS patients were divided into lean and overweight/obese groups, and the PCOS patients were further divided into hyper-AMH and normal-AMH subgroups. Univariate regression was used to assess the unadjusted relationship between AMH and outcome variables, multivariable regression analysis was performed to test whether and how serum AMH levels were associated with BFP after adjusting for other co-variables. Receiver-operating characteristic (ROC) curve analyses were used to test the utility of BFP for the diagnosis of PCOS.ResultsBFP was higher in PCOS patients compared with controls, regardless of obesity. Serum AMH levels were negatively associated with BFP in the PCOS group (r = -0.371; P &lt; 0.001) but not in the control group (r = -0.095; P = 0.385). Multivariable logistic regression analysis showed that elevated BFP was associated with a high risk of PCOS (odds ratio, 1.290; 95% confidence interval, 1.084–1.534, P = 0.004). Furthermore, the combination of BFP and serum AMH into a multivariate model gave an improved area under the curve (AUC) of 88.5%, with a sensitivity of 72.4% and specificity of 87.4%; the positive and negative predictive values were 91.2% and 63.9%, respectively. One limitation of this study is all the conclusion reported was based on small sample size.ConclusionsHerein, we described the negative correlation between BFP and serum AMH levels for the first time, and the present results highlight the importance of further investigation into the role of BFP, especially in body fat-related AMH change as it relates to the underlying pathogenesis of PCOS.
Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway
Authors: Zhao Lei , Wu Qiong , Wang Xiaoli , Wang Shiqi , Shi Xiaoguang , Shan Zhongyan , Teng Weiping 
Published: June 2021

BackgroundHashimoto’s thyroiditis (HT) is an autoimmune disease that features activation of thyroid antigen-specific helper T cells. HT patients have increased Th1 and Th17 T cell subsets. Glycolysis supports chronic activation of Th1 and Th17 T cells, but how this contributes to HT remains unknown.MethodsThe metabolism of CD4+ T cells from 30 HT patients and 30 healthy controls was evaluated by determining the extracellular acidification rate (ECAR) and the oxygen consumption rate (OCR). Mice in a subacute thyroiditis (SAT) model were treated with 2DG, metformin, or combination. Metrics of mTOR/HIF-1α/HK2/glycolysis were measured by western blot and Seahorse assay methods. The severity of SAT was measured by flow cytometry and HE staining.ResultsCD4+ T cells from HT patients had enhanced ECAR and OCR. Levels of Glut1, HK2, PKM2, and LDHA in cultured HT CD4+ T cells were elevated. The expression of HK2 and PKM2 in cultured SAT CD4+ T cells was elevated compared with the control group. Activation of the mTOR and HIF-1α pathways was significant in SAT mice, and expression of HIF-1α in the 2DG treated group was reduced. Treatment with 2DG and/or metformin significantly decreased the ratio of Th17 and Th1 T cells.ConclusionsThyroiditis results in elevation of the mTOR/HIF-1α/HK2/glycolysis pathway in CD4+ T cells. The activation of this pathway is reduced by treatment with 2DG and metformin, which also reverted imbalances in CD4+ T cell differentiation.
Low Energy Electron Irradiation Is a Potent Alternative to Gamma Irradiation for the Inactivation of (CAR-)NK-92 Cells in ATMP Manufacturing
Authors: Walcher Lia , Kistenmacher Ann-Kathrin , Sommer Charline , Böhlen Sebastian , Ziemann Christina , Dehmel Susann , Braun Armin , Tretbar Uta Sandy , Klöß Stephan , Schambach Axel , Morgan Michael , Löffler Dennis , Kämpf Christoph , Blumert Conny , Reiche Kristin , Beckmann Jana , König Ulla , Standfest Bastian , Thoma Martin , Makert Gustavo R. , Ulbert Sebastian , Kossatz-Böhlert Uta , Köhl Ulrike , Dünkel Anna , Fricke Stephan 
Published: June 2021

BackgroundWith increasing clinical use of NK-92 cells and their CAR-modified derivatives in cancer immunotherapy, there is a growing demand for efficient production processes of these “off-the-shelf” therapeutics. In order to ensure safety and prevent the occurrence of secondary tumors, (CAR-)NK-92 cell proliferation has to be inactivated before transfusion. This is commonly achieved by gamma irradiation. Recently, we showed proof of concept that low energy electron irradiation (LEEI) is a new method for NK-92 inactivation. LEEI has several advantages over gamma irradiation, including a faster reaction time, a more reproducible dose rate and much less requirements on radiation shielding. Here, LEEI was further evaluated as a promising alternative to gamma irradiation yielding cells with highly maintained cytotoxic effector function.MethodsEffectiveness and efficiency of LEEI and gamma irradiation were analyzed using NK-92 and CD123-directed CAR-NK-92 cells. LEE-irradiated cells were extensively characterized and compared to gamma-irradiated cells via flow cytometry, cytotoxicity assays, and comet assays, amongst others.ResultsOur results show that both irradiation methods caused a progressive decrease in cell viability and are, therefore, suitable for inhibition of cell proliferation. Notably, the NK-mediated specific lysis of tumor cells was maintained at stable levels for three days post-irradiation, with a trend towards higher activities after LEEI treatment as compared to gamma irradiation. Both gamma irradiation as well as LEEI led to substantial DNA damage and an accumulation of irradiated cells in the G2/M cell cycle phases. In addition, transcriptomic analysis of irradiated cells revealed approximately 12-fold more differentially expressed genes two hours after gamma irradiation, compared to LEEI. Analysis of surface molecules revealed an irradiation-induced decrease in surface expression of CD56, but no changes in the levels of the activating receptors NKp46, NKG2D, or NKp30.ConclusionsThe presented data show that LEEI inactivates (CAR-)NK-92 cells as efficiently as gamma irradiation, but with less impact on the overall gene expression. Due to logistic advantages, LEEI might provide a superior alternative for the manufacture of (CAR-)NK-92 cells for clinical application.