bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of ceramic counter electrode on the properties of dye sensitized solar cell
Authors: Szindler M , Szindler M M , Drygala A , Borylo P , Domanski M 
Published: September 2021

Abstract
Dye sensitized solar cells consisting of a sandwich structure have been a topic outspread in the science for above twenty years and they start a new development trend in obtaining energy from the sun. One the examined aspects of their application is building-integrated photovoltaics. Despite the fact that the higher efficiency of energy conversion was obtained with this type of substrate, glass, due to the cost of production and energy consumption, is disadvantageous in the case of production on an industrial scale. The article presents the possibility of replacing a classic glass substrate with an counter electrode based on a building ceramic tile material. A dye sensitized solar cell was built layer by layer on the tile. A method of atomization was used to deposit fluorine doped tin oxide. After that, a thin layer of platinum was printed. It does not require the use of high temperatures, complicated devices and high costs. Scanning electron microscope, atomic force microscope and Raman spectroscopy were used to evaluate the influence of the transparent conductive oxide layer on the photovoltaic properties of counter electrode tile. Electrical parameters of as prepared DSSCs with and without ceramic tile were characterized by measurements of current-voltage characteristics under standard AM 1.5 radiation. A dye sensitized solar cell integrated with building ceramic tile material was prepared successfully, which efficiency was over 4%.
Effects of bone-plate materials on the healing process of fractured tibia bone under time-varying conditions: a finite element analysis
Authors: Tan JoonHoe , Natarajan Elango , Lim WeiHong , Ramesh S , Ang ChunKit , Parasuraman S , Singh D Kingsly Jeba 
Published: September 2021

Abstract
Stress shielding is known to cause bone refracture or cause low healing rate in fractured bones. The numerical study of bone healing process of a transverse fractured tibia was conducted in this research to reduce the stress shielding. The stress and strain on the callus were evaluated when bone plates of different metallic and non-metallic biomaterials were used. Time varying material properties of the callus were applied, and loading conditions were coupled with material properties of the callus. The strain distribution on the callus, and the maximum stress on the callus and bone plate were analysed. The analysis results shows that Polyether ether ketone/Nano-Hydroxyapatite/Short Carbon Fibre (PEEK/nano-HA/SCF) is most suitable for bone plating application for tibia. PEEK/nano-HA/SCF is chosen as it provides the optimum strain in the callus to promote bone healing. It has the closest stiffness to the cortical bone and hence stress shielding is minimized extensively. It has a uniform strain distribution at the fractured site for early bone healing process.
Convergence problem of Schrödinger equation in Fourier-Lebesgue spaces with rough data and random data
Authors: Yan Xiangqian , Zhao Yajuan , Yan Wei 
Published: September 2021

In this paper, we consider the convergence problem of Schrödinger equation. Firstly, we show the almost everywhere pointwise convergence of Schrödinger equation in Fourier-Lebesgue spaces

H
^

1
p

,

p
2

(

R

)
(
4
≤
p
>
∞
)
,

\hat {H}^{\frac {1}{p},\frac {p}{2}}(\mathbf {R})(4\leq p>\infty ),

H
^

3

s

1

p

,

2
p

3

(

R

2

)
(

s

1

>

1
3

,
3
≤
p
>
∞
)
,

\hat {H}^{\frac {3 s_{1}}{p},\frac {2p}{3}}(\mathbf {R}^{2})(s_{1}>\frac {1}{3},3\leq p>\infty ),

H
^

2

s

2

p

,
p

(

R

n

)
(

s

2

>

n

2
(
n
+
1
)

,
2
≤
p
>
∞
,
n
≥
3
)

\hat {H}^{\frac {2 s_{2}}{p},p}(\mathbf {R}^{n})(s_{2}>\frac {n}{2(n+1)},2\leq p>\infty ,n\geq 3)

with rough data. Secondly, we show that the maximal function estimate related to one dimensional Schrödinger equation can fail with data in

H
^

s
,

p
2

(

R

)
(
s
>

1
p

)

\hat {H}^{s,\frac {p}{2}}(\mathbf {R})(s>\frac {1}{p})

. Finally, we show the stochastic continuity of Schrödinger equation with random data in

L
^

r

(

R

n

)
(
2
≤
r
>
∞
)

\hat {L}^{r}(\mathbf {R}^{n})(2\leq r>\infty )

almost surely. The main ingredients are maximal function estimates and density theorem in Fourier-Lebesgue spaces as well as some large deviation estimates.
Bronchoalveolar Lavage in a Pediatric Population
Authors: Gami Abhishek , Rinaldi Kristina , Degefe Yordanos T , Vosoughi Arghavan Seyed , Lee Dongwoo , Maleki Zahra 
Published: September 2021

Abstract

Objectives
The cytomorphologic findings of bronchoalveolar lavage (BAL) in pediatrics were correlated with clinical symptoms.

Methods
Patient demographics, clinical symptoms/history, cytomorphologic findings, and oil red O (ORO) staining of 100 pediatric patients who underwent BAL between 2014 and 2016 were reviewed at a large academic institution.

Results
Of the 100 patients (males/females, 62:38), the most common conditions for BAL included cough (46/100), reflux (39/100), pneumonia (30/100), dysphagia (22/100), asthma (19/100), and cystic fibrosis (15/100). Sixteen of 100 patients were admitted with pulmonary symptoms from the emergency department. Cytomorphologic findings showed acute inflammation in 37 BALs and chronic inflammation in 9. Abundant thick mucin was present in 3 cytology cases from patients with cystic fibrosis. Fungal elements were detected in 3 cases (Candida, Aspergillus, and Pneumocystis jirovecii) and viral effects (rhinovirus) in one. Thirty-seven of 100 had rare ORO-positive lipid-laden macrophages (LLMs), 7 of 100 had moderate LLMs, 11 of 100 had numerous LLMs, 18 of 100 had positive staining without the degree of staining, 25 of 100 had negative ORO staining, and 2 of 100 had noncontributory ORO staining. An iron stain was done on 15 BALs (2 positive, 9 negative, and 4 noncontributory).

Conclusions
BAL cytology is a useful tool in pediatrics to discriminate underlying causes of aerodigestive system conditions, while ORO staining may occasionally help.
ATPdock: a template-based method for ATP-specific protein–ligand docking
Authors: Rao Liang , Jia Ning-Xin , Hu Jun , Yu Dong-Jun , Zhang Gui-Jun 
Published: September 2021

AbstractMotivationAccurately identifying protein–ATP binding poses is significantly valuable for both basic structure biology and drug discovery. Although many docking methods have been designed, most of them require a user-defined binding site and are difficult to achieve a high-quality protein–ATP docking result. It is critical to develop a protein–ATP-specific blind docking method without user-defined binding sites.ResultsHere, we present ATPdock, a template-based method for docking ATP into protein. For each query protein, if no pocket site is given, ATPdock first identifies its most potential pocket using ATPbind, an ATP-binding site predictor; then, the template pocket, which is most similar to the given or identified pocket, is searched from the database of pocket–ligand structures using APoc, a pocket structural alignment tool; thirdly, the rough docking pose of ATP (rdATP) is generated using LS-align, a ligand structural alignment tool, to align the initial ATP pose to the template ligand corresponding to template pocket; finally, the Metropolis Monte Carlo simulation is used to fine-tune the rdATP under the guidance of AutoDock Vina energy function. Benchmark tests show that ATPdock significantly outperforms other state-of-the-art methods in docking accuracy.Availability and implementationhttps://jun-csbio.github.io/atpdock/.Supplementary informationSupplementary data are available at Bioinformatics online.
Testing microbiome association using integrated quantile regression models
Authors: Wang Tianying , Ling Wodan , Plantinga Anna M , Wu Michael C , Zhan Xiang 
Published: September 2021

AbstractMotivationMost existing microbiome association analyses focus on the association between microbiome and conditional mean of health or disease-related outcomes, and within this vein, vast computational tools and methods have been devised for standard binary or continuous outcomes. However, these methods tend to be limited either when the underlying microbiome-outcome association occurs somewhere other than the mean level, or when distribution of the outcome variable is irregular (e.g. zero-inflated or mixtures) such that conditional outcome mean is less meaningful. We address this gap by investigating association analysis between microbiome compositions and conditional outcome quantiles.ResultsWe introduce a new association analysis tool named MiRKAT-IQ within the Microbiome Regression-based Kernel Association Test framework using Integrated Quantile regression models to examine the association between microbiome and the distribution of outcome. For an individual quantile, we utilize the existing kernel machine regression framework to examine the association between that conditional outcome quantile and a group of microbial features (e.g. microbiome community compositions). Then, the goal of examining microbiome association with the whole outcome distribution is achieved by integrating all outcome conditional quantiles over a process, and thus our new MiRKAT-IQ test is robust to both the location of association signals (e.g. mean, variance, median) and the heterogeneous distribution of the outcome. Extensive numerical simulation studies have been conducted to show the validity of the new MiRKAT-IQ test. We demonstrate the potential usefulness of MiRKAT-IQ with applications to actual biological data collected from a previous microbiome study.Availability and implementationR codes to implement the proposed methodology is provided in the MiRKAT package, which is available on CRAN.Supplementary informationSupplementary data are available at Bioinformatics online.
Surgical treatment of anorectal melanoma: a systematic review and meta-analysis
Authors: Jutten Esther , Kruijff Schelto , Francken Anne Brecht , Lutke Holzik Martijn F , van Leeuwen Barbara L , van Westreenen Henderik L , Wevers Kevin P 
Published: September 2021

AbstractBackgroundAnorectal melanoma is a rare neoplasm with a poor prognosis. The surgical approaches for anorectal melanoma can be categorized into local excision (procedures without lymph node removal and preservation of the rectum) and extensive resection (procedures with rectum and pararectal lymph node removal). The aim of this systematic review and meta-analysis was to compare the survival of patients who underwent extensive resection with that of patients who underwent local excision, stratifying patients according to tumour stage.MethodsA literature review was performed according to PRISMA guidelines by searching MEDLINE/PubMed for manuscripts published until March 2021. Studies comparing survival outcomes in patients with anorectal melanoma who underwent local excision versus extensive resection were screened for eligibility. Meta-analysis was performed for overall survival after the different surgical approaches, stratified by tumour stage.ResultsThere were 347 studiesidentified of which 34 were included for meta-analysis with a total of 1858 patients. There was no significant difference in overall survival between the surgical approaches in patients per stage (stage I odds ratio 1.30 (95 per cent c.i. 0.62 to 2.72, P = 0.49); stage II odds ratio 1.61 (95 per cent c.i. 0.62 to 4.18, P = 0.33); stage I–III odds ratio 1.19 (95 per cent c.i. 0.83 to 1.70, P = 0.35). Subgroup analyses were conducted for the time intervals (&lt;2000, 2001–2010 and 2011–2021) and for continent of study origin. Subgroup analysis for time interval and continent of origin also showed no statistically significant differences in overall survival.ConclusionNo significant survival benefit exists for patients with anorectal melanoma treated with local excision or extensive resection, independent of tumour stage.
Longitudinal Effects of Physical Activity Change on Hippocampal Volumes over up to 12 Years in Middle and Older Age Community-Dwelling Individuals
Authors: Fraser Mark A , Walsh Erin I , Shaw Marnie E , Anstey Kaarin J , Cherbuin Nicolas 
Published: September 2021

AbstractThe objectives of this study were to investigate the long-term associations between changes in physical activity levels and hippocampal volumes over time, while considering the influence of age, sex, and APOE-ε4 genotype. We investigated the effects of change in physical activity on hippocampal volumes in 411 middle age (mean age = 47.2 years) and 375 older age (mean age = 63.1 years) adults followed up to 12 years. An annual volume decrease was observed in the left (middle age: 0.46%; older age: 0.51%) but not in the right hippocampus. Each additional 10 metabolic equivalents (METs, ~2 h of moderate exercise) increase in weekly physical activity was associated with 0.33% larger hippocampal volume in middle age (equivalent to ~1 year of typical aging). In older age, each additional MET was associated with 0.05% larger hippocampal volume; however, the effects declined with time by 0.005% per year. For older age APOE-ε4 carriers, each additional MET was associated with a 0.10% increase in hippocampal volume. No sex effects of physical activity change were found. Increasing physical activity has long-term positive effects on hippocampal volumes and appears especially beneficial for older APOE-ε4 carriers. To optimize healthy brain aging, physical activity programs should focus on creating long-term exercise habits.
Opinion evolution in society with stubborn agents using Temporal Model for Opinion and Triad Network Formation (TMOTNF)
Authors: Jain Eeti , Singh Anurag 
Published: September 2021

Abstract
Information diffusion is an important part of the social network. Information flows between the individuals in the social networks to shape and update their opinions about various topics. The updated opinion values of them further spread the information in the network. The social network is always evolving by nature, leading to the dynamics of the network. Connections keep on changing among the individuals based on the various characteristics of the networks and individuals. Opinions of individuals may again be affected by the changes in the network which leads to dynamics on the network. Therefore, the co-evolving nature of dynamics on/of the network is proposed. Co-evolving Temporal Model for Opinion and Triad Network Formation is modelled to evaluate the opinion convergence. Some fully stubborn agents are chosen in the network to affect opinion evolution, framing society’s opinion. It is also analysed how these agents can divert the whole network towards their opinion values. When temporal modelling is done using all the three conditions, Triadic Closure, Opinion Threshold value and the Page Rank value over the network, the network does not reach consensus at the convergence point. Various individuals with different opinion values still exist.
Natural variation in reproductive timing and X-chromosome nondisjunction inCaenorhabditis elegans
Authors: Lim Jiseon , Kim Jun , Lee Junho 
Published: September 2021

AbstractCaenorhabditis elegans hermaphrodites first produce a limited number of sperm cells, before their germline switches to oogenesis. Production of progeny then ensues until sperm is depleted. Male production in the self-progeny of hermaphrodites occurs following X-chromosome nondisjunction during gametogenesis, and in the reference strain increases with age of the hermaphrodite parent. To enhance our understanding of the reproductive timecourse in C. elegans, we measured and compared progeny production and male proportion during the early and late reproductive periods of hermaphrodites for 96 wild C. elegans strains. We found that the two traits exhibited natural phenotypic variation with few outliers and a similar reproductive timing pattern as previous reports. Progeny number and male proportion were not correlated in the wild strains, implying that wild strains with a large brood size did not produce males at a higher rate. We also identified loci and candidate genetic variants significantly associated with male-production rate in the late and total reproductive periods. Our results provide an insight into life-history traits in wild C. elegans strains.
A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers
Authors: Zhou Lin , Zheng Siqi , Rosas Bringas Fernando R , Bakker Bjorn , Simon Judith E , Bakker Petra L , Kazemier Hinke G , Schubert Michael , Roorda Maurits , van Vugt Marcel A T M , Chang Michael , Foijer Floris 
Published: September 2021

AbstractMaternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy resistance, and tumor recurrence. To determine whether the frequent overexpression of MELK can be exploited in therapy, we performed a high-throughput screen using a library of Saccharomyces cerevisiae mutants to identify genes whose functions become essential when MELK is overexpressed. We identified two such genes: LAG2 and HDA3. LAG2 encodes an inhibitor of the Skp, Cullin, F-box containing (SCF) ubiquitin-ligase complex, while HDA3 encodes a subunit of the HDA1 histone deacetylase complex. We find that one of these synthetic lethal interactions is conserved in mammalian cells, as inhibition of a human homolog of HDA3 (Histone Deacetylase 4, HDAC4) is synthetically toxic in MELK overexpression cells. Altogether, our work identified a novel potential drug target for tumors that overexpress MELK.
The Experience of Alzheimer’s Disease Family Caregivers in a Latino Community: Expectations and Incongruences in Support Services
Authors: Martinez Iveris L , Acosta Gonzalez Elaine , Quintero Caroline , Vania Marsha Jenakovich 
Published: September 2021

Abstract

Objectives
Current theoretical constructs on the utilization of formal support for Latino caregivers focus on familism and exclude the cultural values represented in the service system. The purpose of this paper is to highlight the experience of care for Latino family caregivers to persons with Alzheimer’s disease and related dementias (ADRD). We also examine the cultural congruence between provider perspectives with the expectations of Latino ADRD caregivers.

Method
We conducted extended interviews with 24 Latino ADRD caregivers and 10 service providers. Interview transcripts were coded and analyzed using a grounded theory approach.

Results
Our study provides a deeper understanding of Latino caregiving experiences and highlights some of the structural and systematic issues in current systems of caregiver support. While Latino families have very specific notions of care, by upholding notions of familism, there is a tendency to not look deeper into how they may be better supported in caregiving and fall into the “culture trap.” The assumption that family should be the natural support network for older adults may lead to health and social systems of care to ignore the specific needs of the Latino population.

Discussion
Services are being provided under a model that was established four decades ago and may not reflect current realities. The concept of “an ethics of care” allows us to move beyond familism and explain that underutilization of services may also be due in part to the cultural incongruence between what service providers offer and the perceived needs of Latino caregivers.
Viral Etiology of Acute Gastroenteritis Among Forcibly Displaced Myanmar Nationals and Adjacent Host Population in Bangladesh
Authors: Hossain Mohammad Enayet , Islam Md Muzahidul , Miah Mojnu , Haque Warda , Vinjé Jan , Rahman Mohammed Ziaur , Faruque Abu Syed Golam , Khan Azharul Islam , Ahmed Tahmeed , Rahman Mustafizur 
Published: September 2021

Abstract

Background
Since August 2017, Myanmar nationals from Rakhine state have crossed the border into Bangladesh and settled in Cox’s Bazar, the World’s largest refugee camp. Due to overcrowding, poor sanitation, and hygienic practices they have been under significant health risks including diarrheal diseases. The objective of this study is to determine the viral etiology of acute gastroenteritis (AGE) among forcibly displaced Myanmar nationals (FDMN) and adjacent Bangladeshi local host population (AHP).

Methods
From April 2018 to April 2019, we collected stool specimens from 764 FDMN and 1159 AHP of all ages. We tested 100 randomly selected specimens from each group for the most common AGE viruses.

Results
Among 200 diarrhea patients, 55% and 64% of FDMN and AHP patients, respectively, had viral infections; the most common viruses were rotavirus (29% vs 44%), adenovirus (24% vs 31%), and norovirus (14% vs 10%). In both populations, viral infections were significantly higher in children less than 5 years of age, compared with bacterial infections that were higher in patients older than 5 years of age (P ≤ .05).

Conclusions
Disparities in viral and bacterial prevalence among various age groups warrant careful antibiotic usage, especially in children less than 5 years of age.
Nonadherence to Ledipasvir/Sofosbuvir Did Not Predict Sustained Virologic Response in a Randomized Controlled Trial of Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Persons Who Use Drugs
Authors: Ward Kathleen M , Falade-Nwulia Oluwaseun , Moon Juhi , Sutcliffe Catherine G , Brinkley Sherilyn , Haselhuhn Taryn , Katz Stephanie , Herne Kayla , Arteaga Lilian , Mehta Shruti H , Latkin Carl , Brooner Robert K , Sulkowski Mark S 
Published: September 2021

Abstract

Background
Eliminating hepatitis C virus (HCV) will require effective treatment delivery to persons with substance use disorders (SUDs). We evaluated the relationship between ledipasvir/sofosbuvir treatment persistence (receiving 84 tablets), adherence, and sustained virologic response (SVR) in persons with human immunodeficiency virus (HIV)/HCV coinfection.

Methods
Of the 144 participants with HIV/HCV and SUDs, 110 initiated a 12-week treatment course under 1 of 3 conditions (usual care, peer mentors, and cash incentives). We used self-report, pharmacy pill counts, and expected date of refill to examine adherence. Persistent participants were categorized as high adherence (taking ≥90% of doses) or low adherence (taking &lt;90% of doses).

Results
Most participants persisted on treatment after initiation (n = 105), with 95% (n = 100) achieving SVR. One third (34%) of participants had moderate/heavy alcohol use by the biomarker phosphatidylethanol ([Peth] ≥50 ng/mL), and 44% had urine toxicology positive for cocaine or heroin at enrollment. The proportion of persons with high adherence was 72% (n = 76), and the proportion of persons with low adherence was 28%. Although low adherence was associated with moderate/heavy alcohol use by PEth (relative risk = 2.77; 95% confidence interval, 1.50–5.12), SVR did not vary according to adherence (P = .702), and most participants (97%) with low adherence achieved SVR.

Conclusions
Treatment persistence led to high SVR rates among persons with HIV/HCV, despite imperfect adherence and SUDs.