bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal abstinence syndrome is a potential cause of low TREC copy number
Authors: Adatia Adil , Ling Ling , Chakraborty Pranesh , Brick Lauren , Brager Rae 
Published: November 2021

AbstractSevere combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.
Chronic gastrointestinal bleeding caused by a Dieulafoy’s lesion in the small intestine: a case report
Authors: Salimi Javad , Behzadi Mohamad , Ramandi Alireza , Jafarinia Mehdi , Zand Hamid , Pirouzian Mohammad 
Published: November 2021

Abstract
Introduction
Dieulafoy’s lesion, first found by Paul Georges Dieulafoy, is an infrequent but important cause of recurrent upper gastrointestinal bleeding. The bleeding is usually severe, but patients rarely present with chronic, occult gastrointestinal bleeding.

Case presentation
In this article, we discuss the case of a 68-year-old caucasian man with a history of recurrent hematemesis and chronic anemia with evidence of extravasation of contrast in the lumen of the bowel loop on computed tomography angiography. The patient was taken to the operating room, and a laparotomy procedure was performed.

Conclusion
Due to the infrequency of Dieulafoy’s lesion compared with other causes of gastrointestinal bleeding, it is often missed in the process of differential diagnosis. In this article, we have demonstrated the importance of this disease and different approaches to the treatment of this lesion, considering the location of the lesion among other factors.
Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice
Authors: Li Chenghai , Zhao Hua , Cheng Linna , Wang Bin 
Published: November 2021

AbstractMesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from self or donors have their own advantages and disadvantages in their medical practice. Therapeutic benefits of using autologous vs. allogeneic MSCs are inconclusive. Transplanted MSCs within the body interact with their physical microenvironment or niche, physiologically or pathologically, and such cells in a newly established tissue microenvironment may be impacted by the pathological harmful environmental factors to alter their unique biological behaviors. Meanwhile, a temporary microenvironment/niche may be also altered by the resident or niche-surrounding MSCs. Therefore, the functional plasticity and heterogeneity of MSCs caused by different donors and subpopulations of MSCs may result in potential uncertainty in their safe and efficacious medical practice. Acknowledging a connection between MSCs’ biology and their existing microenvironment, donor-controlled clinical practice for the long-term therapeutic benefit is suggested to further consider minimizing MSCs potential harm for MSC-based individual therapies. In this review, we summarize the advantages and disadvantages of autologous vs. allogeneic MSCs in their therapeutic applications. Among other issues, we highlight the importance of better understanding of the various microenvironments that may affect the properties of niche-surrounding MSCs and discuss the clinical applications of MSCs within different contexts for treatment of different diseases including cardiomyopathy, lupus and lupus nephritis, diabetes and diabetic complications, bone and cartilage repair, cancer and tissue fibrosis.
Fatigue driving detection based on electrooculography: a review
Authors: Tian Yuanyuan , Cao Jingyu 
Published: November 2021

AbstractTo accurately identify fatigued driving, establishing a monitoring system is one of the important guarantees of improving traffic safety and reducing traffic accidents. Among many research methods, electrooculogram signal (EOG) has unique advantages. This paper presents a systematic literature review of these technologies and summarizes a basic framework of fatigue driving monitoring system based on EOGs. Then we summarize the advantages and disadvantages of existing technologies. In addition, 80 primary references published during the last decade were identified. The multi-feature fusion technique based on EOGs performs better than other traditional methods due to its low cost, low power consumption and low intrusion, while its application is still limited which needs more efforts to obtain good and generalizable results. And then, an overview of the literature on technology is given, revealing a premier and unbiased survey of the existing empirical research of classification techniques that have been applied to fatigue driving analysis. Finally, this paper adds value to the current literature by investigating the application of EOG signals in fatigued driving and the design of related systems, future guidelines have been provided to practitioners and researchers to grasp the major contributions and challenges in the state-of-the-art research.
Quantitative analysis of galactose using LDI-TOF MS based on a TiO2 nanowire chip
Authors: Noh Joo-Yoon , Kim Moon-Ju , Kim Mira , Kim Jo-Il , Park Jong-Min , Yun Tae Gyeong , Kang Min-Jung , Pyun Jae-Chul 
Published: November 2021

AbstractA novel method for quantifying galactose was developed to serve as a newborn screening test for galactosemia using laser desorption/ionization time-of-flight (LDI-TOF) mass spectrometry (MS) with a TiO2 nanowire chip. Herein, phosphate citrate buffer, serum, and dried blood spot (DBS) were employed for the quantitative analysis of galactose. To quantitatively analyze galactose, its reduction potential was used to oxidize o-phenylene diamine (OPD) into 2,3-diaminophenazine (DA), which were both detected using LDI-TOF MS with a TiO2 nanowire chip according to the concentration of galactose. The reproducibility and the interference of glucose were determined to demonstrate the applicability of this method. Moreover, mixtures of galactose, phenylalanine, and 17 α-OHP were analyzed to determine the interference induced by other biomarkers of metabolic disorders. The OPD oxidation of galactose was found to be selectively achieved under high-glucose conditions, similar to human blood, thereby showing good reproducibility. The intensities of the mass peaks of OPD and DA based on LDI-TOF MS with a TiO2 nanowire chip were linearly correlated in the galactose concentration range of 57.2–220.0 μg/mL (r2 = 0.999 and 0.950, respectively) for serum samples and 52.5–220.0 μg/mL (r2 = 0.993 and 0.985, respectively) for DBS after methanol precipitation/extraction. The enzyme immunoassay and LDI-TOF MS analysis results were statistically analyzed, and a mixture of phenylalanine, 17 α-OHP, and galactose was simultaneously investigated quantitatively at the cutoff level.
Authentic STEM research, practices of science, and interest development in an informal science education program
Authors: Habig Bobby , Gupta Preeti 
Published: November 2021

Abstract
Background
Two critical challenges in science education are how to engage students in the practices of science and how to develop and sustain interest. The goal of this study was to examine the extent to which high school youth, the majority of whom are members of racial and ethnic groups historically underrepresented in STEM, learn the skills and practices of science and in turn develop interest in conducting scientific research as part of their career pursuits. To accomplish this goal, we applied Hidi and Renninger’s well-tested theoretical framework for studying interest development in the context of a museum-based, informal science education (ISE) program. We used a mixed methods approach, incorporating both survey and interview data, to address three research questions: (1) As youth engage in authentic science research, do they develop perceived competence in mastering the skills and practices of science? (2) Do participants increase, maintain, or decrease interest in science research as a result of this experience? (3) How does participation in scientific practices manifest in non-program contexts?

Results
Our study yielded three main results. First, we found that participants developed competence in mastering several of the skills and practices of science. Strikingly, there was significant improvement in self-reported level of competency for 15 specific research skills. Second, we found that participants maintained their interest in scientific research over time. Our post-survey results revealed that one hundred percent of students were either excited about or expressed deep interest in scientific research. Based on a Phases of Interest Development Rubric developed for this study, most participants exhibited emerging individual interest. Finally, participants exhibited significant increases in the frequency in which they engaged in scientific practices outside of the program.

Conclusions
Our findings suggest that participation in authentic research in an ISE context affords youth critical opportunities for gaining mastery of several of the skills and practices of science, which in turn reinforces, and in some cases increases participants’ interest in scientific research beyond the span of the program.
Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
Authors: Serizawa Kenichi , Tomizawa-Shinohara Haruna , Miyake Shota , Yogo Kenji , Matsumoto Yoshihiro 
Published: November 2021

Abstract
Background
Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS and NMOSD are autoimmune disorders of the central nervous system, and ≥ 50% of patients with these disorders experience chronic neuropathic pain. The currently available medications for the management of neuropathic pain have limited effectiveness in patients with MS and NMOSD, and there is an unmet medical need to identify novel therapies for the management of chronic neuropathic pain in these patients. In this review article, we summarize the role of interleukin-6 (IL-6) in the pathogenesis of MS and NMOSD and the ameliorative effects of anti–IL-6 therapies in mouse models of experimental autoimmune encephalomyelitis (EAE).

Main body
Intraperitoneal injection of MR16-1, an anti–IL-6 receptor (IL-6R) antibody, reduced mechanical allodynia and spontaneous pain in EAE mice, which was attributed to a reduction in microglial activation and inhibition of the descending pain inhibitory system. The effect of anti–IL-6 therapies in ameliorating neuropathic pain in the clinical setting is controversial; a reduction in pain intensity has been reported with an anti–IL-6 antibody in four studies, namely a case report, a pilot study, a retrospective observational study, and a case series. Pain intensity was evaluated using a numerical rating scale (NRS), with a lower score indicating lesser pain. A reduction in the NRS score was reported in all four studies. However, in two randomized controlled trials of another anti–IL-6R antibody, the change in the visual analog scale pain score was not statistically significantly different when compared with placebo. This was attributed to the low mean pain score at baseline in both the trials and the concomitant use of medications for pain in one of the trials, which may have masked the effects of the anti–IL-6R antibody on neuropathic pain.

Conclusion
Thus, anti–IL-6 therapies might have a potential to reduce neuropathic pain, but further investigations are warranted to clarify the effect of inhibition of IL-6 signaling on neuropathic pain associated with MS and NMOSD.
The ‘New Urban Science’: towards the interdisciplinary and transdisciplinary pursuit of sustainable transformations
Authors: Karvonen Andrew , Cvetkovic Vladimir , Herman Pawel , Johansson Karl , Kjellström Hedvig , Molinari Marco , Skoglund Mikael 
Published: November 2021

AbstractDigitalisation is an increasingly important driver of urban development. The ‘New Urban Science’ is one particular approach to urban digitalisation that promises new ways of knowing and managing cities more effectively. Proponents of the New Urban Science emphasise urban data analytics and modelling as a means to develop novel insights on how cities function. However, there are multiple opportunities to broaden and deepen these practices through collaborations between the natural and social sciences as well as with public authorities, private companies, and civil society. In this article, we summarise the history and critiques of urban science and then call for a New Urban Science that embraces interdisciplinary and transdisciplinary approaches to scientific knowledge production and application. We argue that such an expanded version of the New Urban Science can be used to develop urban transformative capacity and achieve ecologically resilient, economically prosperous, and socially robust cities of the twenty-first century.
Disentangling capacity and the First-tier Tribunal: bringing case law into clinical practice
Authors: Jawaid Zumer Arif , Brindle Nick , Kennedy Michael 
Published: November 2021

SUMMARYIt has been common clinical practice for staff members to make an application to a mental health tribunal (the First-tier Tribunal (Mental Health) in England or the Mental Health Review Tribunal in Wales) on behalf of a patient detained in hospital for psychiatric treatment who may lack capacity to make that application, for example in dementia in-patient settings. Following a series of cases in the Upper Tribunal, such practice may not be appropriate and there is now a risk that the application will be struck out. It is important that clinicians are aware of developments in case law and therefore we provide guidance on how clinicians should approach applications to the tribunal and the assessments of capacity that may be required.
From the Margins to the Center
Authors: Braun Jolie 
Published: November 2021

AbstractSelf-publishing is a topic not typically discussed in the literature classroom, yet it can provide an opportunity to highlight voices and works from the margins, think critically about the publishing methods, and promote the study of the book as a cultural artifact. This article provides a case study on using special collections materials to teach undergraduates about self-published American literature. It includes suggestions about how to find and select materials, details about facilitating a discussion and a hands-on activity on the topic, and recommendations for adapting these ideas for other teaching contexts.
What Does a Good Teacher Do Now?
Authors: Day Jathan , Hughes Sarah , Zanders Crystal , Van Zanen Kathryn , Moos Andrew 
Published: November 2021

Abstract
Five graduate students reflect on their experiences in multiple roles to address the question, What does a good teacher do now?—during a pandemic, in a moment of reckoning with white supremacy, in the face of uncounted griefs and challenges. We contend that good teachers craft communities of care for students, colleagues, and themselves. We advance trauma, accessibility, surveillance, and labor as particular sites for that project.
Radiation and Environmental Aspects of Advanced Nuclear Energy
Authors: Linge I. , Utkin S. 
Published: November 2021

The article focuses on the role of radiation criteria and its evolution in the structure of arguments underlying the establishment, operation and development of nuclear energy. It demonstrates that the dominant role of radiation criteria should be reconsidered to allow broader consideration of environmental and other factors associated with sustainable development.
Based on in-depth analysis of certain aspects relevant for the mutual development of nuclear energy and radiation and environmental safety requirements, the paper shows that fully-fledged regulatory and technological systems have been deployed to date to ensure the radiation safety of workers and the public: these systems cover all the tasks required to be addressed to limit the technogenic exposure under normal operation. At the same time, an unprecedented gap was noticed between the actual role of radiation factor across human health risks and its perception by the overwhelming part of society.
In the near future (some hundred years), urgent tasks in the field of radiation safety will be driven, on the one hand, by the need to ensure the internal consistency of the national security system addressing health risks in general, and on the other, by global processes in the world economy associated with slow growth in energy demand, rapid reduction in the share of fossil fuels in almost all sectors of the economy among the developed countries, including transport, growing general environmental trends towards material recycling and decarbonization. The study shows what should be the attitude to radiation risks so that the nuclear energy could successfully meet the requirements arising from these trends. In this regard, the paper also provides some rational interpretation of the principle suggesting that no undue burden should be imposed on future generations.
Measurement of the refractive index at cryogenic temperature of absorptive silver thin films used as reflectors in a Fabry–Perot cavity
Authors: Rosenziveig Kevin , Soumann Valérie , Abbé Philippe , Dubois Benoît , Cohadon Pierre-François , Passilly Nicolas , Galliou Serge 
Published: November 2021

Data on the refractive index of silver thin films are scarce in the literature, and largely dependent on both the deposition method and thickness. We measure the refractive index of silver films at cryogenic temperature with a technique that takes advantage of the absorption of the films and the corresponding peculiar properties of Fabry–Perot cavities: a frequency shift between the reflection and transmission peaks, together with a modified cavity bandwidth. We demonstrate a decrease in the real value of the refractive index, together with a decrease in its imaginary value at 4 K.
Wideband full double-pass serial hybrid fiber amplifier utilizing L-shape configuration
Authors: Khudhair Aseel A. , Ali M. H. , Abass A. K. 
Published: November 2021

In this work, a new, to the best of our knowledge, full double-pass serial hybrid fiber amplifier is simulated on OptiSystem 7.0 software. A wideband flat gain spectrum covered both conventional and long communication bandwidth (C+L) from 1530 to 1590 nm, which is approximately 60 nm with high average gain of 23.6 dB; acceptable noise figure of 7 dB is achieved via the L-shape configuration. The main innovative step in the proposed design is decreasing the cascading amplification effect between the combined amplifiers, by making the individual full double-pass for the input signal in each amplifier stage.
The Art of 6G (TAO 6G): how to wire Society 5.0 [Invited]
Authors: Maier Martin , Ebrahimzadeh Amin , Beniiche Abdeljalil , Rostami Sajjad 
Published: November 2021

The opening Optical Fiber Communication Conference and Exhibition 2021 plenary talk on how technologies and applications drive the evolution of networking concluded by presenting the equation Networking = Art + Science + Engineering. Due to their growing complexity, modern networks may be better viewed as techno-social systems that resemble biological superorganisms. In this paper, we expand on the aforementioned equation in the context of future 6G mobile networks, putting a focus on its first part, the Art of 6G (TAO 6G). To set the stage, we first elaborate on the 6G vision from an optical fiber fixed networks perspective, taking into account the respective viewpoints of the International Telecommunication Union-Telecommunication Standardization Sector and the FTTH Council Europe as well as the European Telecommunications Standards Institute’s recently launched fifth-generation fixed network initiative of bringing fiber to everywhere and everything, which is supposed to be the foundation of the new digital age and is a prerequisite for the digital transformation of the whole society. Towards this end, we present our ideas on what the digital society of the future will or potentially could look like. After briefly reviewing our work on tactile immersive use cases of so-called cyber-physical-social systems (CPSS), we inquire into the emerging human-centric Industry 5.0 and its mutually beneficial underlying principles of digitalization and, more interestingly, biologization. Specifically, we borrow ideas from biological superorganisms with brain-like cognitive capabilities found in natural societies for a stigmergy-enhanced Society 5.0, using tokenized digital twins for advancing collective intelligence in CPSS via indirect communication. Finally, we present our CPSS-based bottom-up token engineering framework designed for Society 5.0.
Long range dynamic displacement: precision PGC with sub-nanometer resolution in an LWSM interferometer
Authors: Dong Yisi , Hu Peng-Cheng , Fu Haijin , Yang Hongxing , Yang Ruitao , Tan Jiubin 
Published: November 2021

We propose a precision phase-generated-carrier (PGC) demodulation method with sub-nanometer resolution that avoids nonlinear errors in a laser wavelength sinusoidal modulation fiber-optic interferometer for long range dynamic displacement sensing. Using orthogonal detection and an AC-DC component extraction scheme, the PGC carrier phase delay (CPD) and laser intensity modulation phase delay can be obtained simultaneously to eliminate the nonlinear error from accompanied optical intensity modulation and CPD. Further, to realize long range displacement sensing, PGC phase modulation depth (PMD), determined by the laser wavelength modulation amplitude and the working distance of the interferometer, is required to maintain an optimal value during measurement, including initial position and dynamic movement. By combining frequency sweeping interference and modified PGC-arctan demodulation to measure real-time working distance, adaptive PMD technology is realized based on proportion control. We construct a fiber-optic Michelson and SIOS commercial interferometer for comparison and perform experiments to verify the feasibility of the proposed method. Experimental results demonstrate that an interferometer with sub-nanometer resolution and nanometer precision over a large range of 400 mm can be realized.
Digitales Lernen und Lehren: Führt Corona zu einer zeitgemäßen Bildung?
Authors: Grogorick Linda , Robra-Bissantz Susanne 
Published: November 2021

ZusammenfassungZum Schutz vor Corona musste das Lernen und Lehren an Hochschulen, Schulen sowie anderen Aus- und Weiterbildungseinrichtungen zeitweise nahezu vollständig ins Digitale überführt werden. Doch auch schon vor Corona hat kaum noch jemand ausschließlich analog, also ohne digitale Unterstützung, gelernt. Das (digitale) Lernen befindet sich bereits seit längerem im Wandel. Deswegen widmet sich dieser Beitrag einerseits der Thematik, wie sich das Lernen im Allgemeinen sowie mögliche Lernformate gewandelt haben und andererseits, wie Corona das Lernen an Schulen, Hochschulen sowie anderen Aus- und Weiterbildungseinrichtungen verändert hat.