bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural changes in the oral microbiome of the adolescent patients with moderate or severe dental fluorosis
Authors: Wang Qian , Chen Xuelan , Hu Huan , Wei Xiaoyuan , Wang Xiaofan , Peng Zehui , Ma Rui , Zhao Qian , Zhao Jiangchao , Liu Jianguo , Deng Feilong 
Published: February 2021

AbstractDental fluorosis is a very prevalent endemic disease. Although oral microbiome has been reported to correlate with different oral diseases, there appears to be an absence of research recognizing any relationship between the severity of dental fluorosis and the oral microbiome. To this end, we investigated the changes in oral microbial community structure and identified bacterial species associated with moderate and severe dental fluorosis. Salivary samples of 42 individuals, assigned into Healthy (N = 9), Mild (N = 14) and Moderate/Severe (M&S, N = 19), were investigated using the V4 region of 16S rRNA gene. The oral microbial community structure based on Bray Curtis and Weighted Unifrac were significantly changed in the M&S group compared with both of Healthy and Mild. As the predominant phyla, Firmicutes and Bacteroidetes showed variation in the relative abundance among groups. The Firmicutes/Bacteroidetes (F/B) ratio was significantly higher in the M&S group. LEfSe analysis was used to identify differentially represented taxa at the species level. Several genera such as Streptococcus mitis, Gemella parahaemolysans, Lactococcus lactis, and Fusobacterium nucleatum, were significantly more abundant in patients with moderate/severe dental fluorosis, while Prevotella melaninogenica and Schaalia odontolytica were enriched in the Healthy group. In conclusion, our study indicates oral microbiome shift in patients with moderate/severe dental fluorosis. We identified several differentially represented bacterial species enriched in moderate and severe fluorosis. Findings from this study suggests that the roles of these bacteria in oral health and related diseases warrant more consideration in patients with moderate and severe fluorosis.
Measurement of the hydrogen bond acceptance of ionic liquids and green solvents by the 19F solvatomagnetic comparison method
Authors: Laurence Christian , Mansour Sergui , Vuluga Daniela , Legros Julien 
Published: February 2021

A 19F solvatomagnetic comparison of 4-fluorophenol and 4-fluoroanisole yields a more reliable measurement of the hydrogen-bond acceptance of ionic liquids and green solvents than the solvatochromic comparison method.
RETRACTED: Prediction of energy consumption of numerical control machine tools and analysis of key energy‐saving technologies
Authors: Qiang Han , Ikbal Mohammad Asif , Khanna Shaweta 
Published: February 2021

AbstractThe objective of this study is to ensure the sustainable development of traditional machinery manufacturing industry under limited conditions of non‐renewable energy, and reduce the environmental pollution caused by high energy consumption of machine tools. Here the energy consumption of numerical control machine tools is analysed, and the relevant energy‐saving model is established. The energy consumption system of the numerical control machinery tools, including the cutting parameters, is classified. The relevant energy consumption prediction model is built to evaluate the influence of different cutting parameters, feed per tooth, and the back cutting depth on the energy consumption of numerical control machine tools. The results show that classifying the energy consumption system of numerical control machine tools can effectively predict the energy consumption of machine tools, which provides theoretical support for the subsequent energy‐saving experiments. Larger cutting parameters will increase the energy consumption of numerical control machine tools, improve the energy efficiency of machine tools at the same time. Thus, reducing the feed per tooth and the back cutting depth can effectively decrease its energy consumption. The results of this study provide data support and guidance for the energy‐saving experiments and practical applications of numerical control machine tools.
Collaborative transmit resource scheduling and waveform selection for target tracking in multistatic radar system
Authors: Wang Yijie , Shi Chenguang , Wang Fei , Zhou Jianjiang 
Published: February 2021

AbstractThis paper proposes a collaborative transmit resource scheduling and waveform selection (CTRSWS) strategy for target tracking in multistatic radar system which consists of one transmitter and an arbitrary number of receivers. The main mechanism of the proposed CTRSWS strategy is to exploit the optimisation technique to jointly optimise the illumination power, dwell time, waveform bandwidth, and pulse length under the constraints of several resource budgets and the predefined waveform library, aiming at improving the low probability of intercept (LPI) performance and target tracking accuracy of multistatic radar system simultaneously. The analytical expressions for the probability of intercept and the trace of the predicted error covariance matrix corresponding to the target state estimation are derived and adopted to evaluate the LPI performance and target tracking accuracy, respectively. Subsequently, the resulting non‐convex and non‐linear optimisation problem is resolved by an efficient and fast four‐stage solution methodology. Several numerical results are provided to verify the effectiveness and superiority of the proposed CTRSWS scheme in terms of the achievable LPI performance and target tracking accuracy of multistatic radar system.
Underwater source localization in the presence of strong interference
Authors: Li Haipeng , Jakobsson Andreas , Sun Dajun , Zheng Cuie 
Published: February 2021

AbstractThe underwater localization of a broadband target in the presence of strong interference and noise has been widely investigated. A novel clutter suppression approach based on oblique projections is proposed, exploiting the prior information of the expected target response. The method uses a generalised likelihood ratio formulation to select the oblique projection best matching the measured data. The performance of the proposed method is verified through numerical examples and measured sonar data. The results indicate that the method provides good performance for time difference of arrival estimation and target localization under low signal to clutter ratio as compared to existing methods.
MiRNA‐145‐5p expression and prospective molecular mechanisms in the metastasis of prostate cancer
Authors: Huang Zhi‐Guang , Sun Yu , Chen Gang , Dang Yi‐Wu , Lu Hui‐Ping , He Juan , Cheng Ji‐Wen , He Mao‐Lin , Li Sheng‐Hua 
Published: February 2021

AbstractThe clinicopathological implication and prospective molecular mechanisms of miRNA‐145‐5p in the metastasis of prostate cancer (PCa) stand unclear. Herein, it is found that miRNA‐145‐5p expression was remarkably reduced in 131 cases of metastatic PCa than 1371 cases of localised ones, as the standardised mean differences (SMD) was −1.26 and the area under the curve (AUC) was 0.86, based on miRNA‐chip and miRNA‐sequencing datasets. The potential targets of miRNA‐145‐5p in metastatic PCa (n = 414) was achieved from the intersection of miRNA‐145‐5p transfected metastatic PCa cell line data, differential expression of metastatic PCa upregulated genes and online prediction databases. TOP2A was screened as one of the target hub genes by PPI network analysis, which was adversely related to miRNA‐145‐5p expression in both metastatic PCa (r = −0.504) and primary PCa (r = −0.281). Gene‐chip and RNA‐sequencing datasets, as well as IHC performed on clinical PCa samples, showed consistent upregulated expression of TOP2A mRNA and protein in PCa compared with non‐PCa. The expression of TOP2A mRNA was also significantly higher in metastatic than localised PCa with the SMD being 1.72 and the AUC of sROC being 0.91. In summary, miRNA‐145‐5p may participate in PCa metastasis by binding TOP2A and be useful as a biomarker for the detection of metastatic PCa.
Spatially resolved properties of galaxies with a kinematically distinct core
Authors: Omori Kiyoaki Christopher , Takeuchi Tsutomu T. 
Published: February 2021

Aims. Interacting galaxies show unique irregularities in their kinematic structures. By investigating the spatially resolved kinematics and stellar population properties of galaxies that demonstrate irregularities, we can paint a detailed picture of the formation and evolutionary processes that took place during their lifetimes.
Methods. In this work, we focused on galaxies with a specific kinematic irregularity: a kinematically distinct stellar core (KDC). In particular, we considered counter-rotating galaxies in which the core and main body of are rotating in opposite directions. We visually identified 11 MaNGA galaxies with a KDC from their stellar kinematics, and we investigated their spatially resolved stellar and gaseous kinematic properties, namely the two-dimensional stellar and gaseous velocity and velocity-dispersion (σ) maps. Additionally, we examined the stellar population properties, as well as spatially resolved recent star formation histories, using the Dn4000 and Hδ gradients.
Results. The galaxies display multiple off-centred symmetrical peaks in the stellar σ maps. The gaseous velocity and σ maps display regular properties. The stellar population properties and their respective gradients show differing properties depending on the results of the spatially resolved emission line diagnostics of the galaxies, with some but not all galaxies showing inside-out quenching. The star formation histories also largely differ based on the spatially resolved emission line diagnostics, but most galaxies show indications of recent star formation either in their outskirts or core.
Conclusions. We find a distinct difference in kinematic and stellar population properties in galaxies with a counter-rotating stellar core, which depends on its classification using spatially resolved emission line diagnostics.
COVID-19 und Plastische Chirurgie – Schönheitschirurgie oder wichtiger Bestandteil der medizinischen Versorgung?
Authors: Popp Daniel , Smolle Christian , Nischwitz Sebastian P. , Sawetz Isabelle , Schaunig Caroline , Winter Raimund , Spendel Stephan , Kamolz Lars-Peter 
Published: February 2021

Zusammenfassung
Einleitung Im Frühjahr 2020 machte die COVID-19-Pandemie weitreichende Veränderungen und Maßnahmen in bisher nie dagewesenem Ausmaß notwendig. Diese Maßnahmen zielten einerseits darauf ab die Ausbreitung der Virusinfektion einzudämmen, und andererseits die landesweite Krankenversorgung weiterhin zu gewährleisten, insbesondere um im Falle einer größeren Anzahl an mit COVID-19 infizierten Patienten ausreichend Intensivkapazitäten zur Verfügung zu haben. In Bezug auf operative Fächer bedeutete dies das temporäre Aussetzen des Elektivprogramms auf unbestimmte Zeit. Ziel dieser Studie war es die Auswirkung dieser Maßnahmen auf das Behandlungsspektrum eines plastisch-chirurgischen Zentrums zu evaluieren.
Methode Die Operationszahlen der klinischen Abteilung für Plastische, Ästhetische und Rekonstruktive Chirurgie der medizinischen Universität Graz während des sog. Lockdowns von 16.3.2020 bis 26.4.2020 (6 Wochen) sowie 2 Wochen davor wurden retrospektiv erhoben. Die Daten wurden zum korrespondierende Vorjahreszeitraum verglichen. Untersucht wurden u. a. Operationsspektrum, Dringlichkeit, Indikation und Komplikationsraten.
Ergebnisse Durch den Wegfall des Elektivprogramms kam es während des Lockdowns im Jahresvergleich zu einem signifikanten Rückgang der OP-Zahlen um 57,5 % (2019: 353, 2020 150 Fälle). Während des Lockdowns wurden im Jahresvergleich signifikant mehr Notfall- und Akuteingriffe durchgeführt (2019: 41, 2020: 58 Fälle, p < 0,001). Außerdem wurde eine signifikante Häufung von Selbstverletzungen bzw. Suizidversuchen beobachtet (2019: 0, 2020: 16 Fälle, p > 0,001). Hinsichtlich Privat- und Arbeitsunfällen gab es keine signifikanten Unterschiede. Es zeigte sich auch kein signifikanter Unterschied bezüglich der Komplikationsrate (2019: 6,8, 2020: 10 %, p = 0,219).
Zusammenfassung Ein signifikanter Anteil plastisch-chirurgischer Operationen an einem Universitätsklinikum mit überregionalem Versorgungsauftrag besteht aus Notfalloperationen, akuten und dringenden medizinisch notwendigen Operationen. Während des Lockdowns wurden Operationen ohne signifikanten Anstieg der Komplikationsrate durchgeführt. Trotz sämtlicher Herausforderungen während der Pandemie konnte eine qualitativ konstante Patientenversorgung auf höchstem Niveau gewährleistet werden. Um die während des Lockdowns angehäuften weniger dringenden, jedoch ebenso wichtigen Fälle zeitgerecht und in entsprechend hoher Qualität abzuarbeiten, wird eine Erweiterung der Operationskapazitäten mit Steigerung der Bettenanzahl und der Ambulanzkapazität notwendig sein. Die vorliegenden Ergebnisse zeigen, wie wichtig die Plastische Chirurgie für die medizinische Versorgung insbesondere in Krisenzeiten ist.
Latest Trends in the Current Treatment of Proximal Humeral Fractures – an Analysis of 1162 Cases at a Level-1 Trauma Centre with a Special Focus on Shoulder
Surgery
Authors: Dey Hazra Rony-Orijit , Blach Robert Maximilian , Ellwein Alexander , Katthagen Jan Christoph , Lill Helmut , Jensen Gunnar 
Published: February 2021

Abstract
Background The management of proximal humeral fracture (PHF) is not only complex but ever changing. Published epidemiological data are often dated and do not factor in demographic
changes or the latest developments in implant material and surgical techniques.
Aims The primary aim of this study was to evaluate changes in the epidemiology and actual treatment of PHF at a level-1 trauma centre, with a special focus on shoulder surgery.
Hypotheses 1. Between 2009 to 2012 and 2014 to 2017, an increase in complex PHF entities can be observed. 2. In correlation with fracture complexity, an increasing number of
comorbidities, especially osteoporosis, can be observed.
Methods Between 2014 and 2017, a total of 589 patients (73% female; mean age: 68.96 ± 14.9 years) with 593 PHFs were treated. Patient records and imaging (XRs and CTs) of all
patients were analysed. Fractures with ad latus displacement of a maximum of 0,5 cm and/or humeral head angulation of less than 20° were classified as non-displaced. Patients with displaced
fractures were included in the analysis of the therapeutic algorithm. These results were compared to those of a cohort 2009 to 2012 (566 patients, 569 PHFs), which used the same inclusion
criteria.
Results The two cohorts showed comparable patient numbers, as well as gender and age distributions. Between 2009 to 2012 and 2014 to 2017, a decrease in 2-part fractures (13.9 to
8.6%) and a simultaneous increase in 4-part fractures (20.4 to 30%), and thus fracture complexity was observed. Further decreases were observed in conservative therapy (27.8 to 20.6%), nail
osteosynthesis (10.7 to 2.7%) and anatomic shoulder arthroplasty (5,4 to 1%). Furthermore, there was an increase in the use of locking plate osteosynthesis (43.2 to 56.7%) and reverse
shoulder arthroplasty (9 to 18.4%). The general trend shows an increase in surgical therapy between the years (72.2 to 79.4%), as well as an increase in osteoporosis incidence (13 to 20.6%).
The greatest numbers of comorbidities were found in 3- and 4-part fractures.
Conclusion There is an increase in both the complexity of fractures and the number of surgically treated fractures between 2009 and 2012. Furthermore, an increase in osteoporosis
numbers can be observed. New implants (PEEK, fenestrated screws for cement augmentation) and new surgical techniques (double plating osteosynthesis) were used as a result of increasing
fracture complexity. Moreover, reverse total shoulder arthroplasty was used more commonly.
Atypical Manifestations of Dengue Fever in Children
Authors: Ramanan Padmasani Venkat , Shruti T. K , Rajakumar P. S. , Sankaranarayanan Shuba 
Published: February 2021

Abstract
Objective The burden of dengue fever (DF) is increasing rapidly worldwide. Several atypical manifestations of DF are being increasingly reported but there are no clear guidelines on their definition and management. Their timely detection and appropriate management might improve outcomes. We describe here our experience in managing atypical manifestations of DF in children and their outcomes in a teaching hospital in South India.
Methods A retrospective chart review of children (1 month–18 years) hospitalized, between August 2017 and March 2018 with a diagnosis of DF (NS1 antigen or immunoglobulin M antibodies positivity), was done. The clinical details of the atypical manifestations are described.
Results During the study period, 925 children were hospitalized with DF, of which 94 (10.16%) had severe dengue and 2 (0.21%) died. Among the 925 children, 7 (0.75%) had cardiac, 5 (0.54%) had neurological, 5 (0.54%) had hepatic, and 31 (3.3%) had immunological (infection-associated immune dysregulation) manifestations.
Conclusion Most children with atypical manifestations of DF recover with supportive management. There is a need for a clear definition of atypical manifestations so that large prospective multicenter studies on incidence, optimum management, and outcomes can be done.
Medical Management in Focal versus Generalized Epilepsy
Authors: Sannagowdara Kumar , Khan Nadir 
Published: February 2021

AbstractAbout 70% of children with new-onset epilepsy have the potential to become seizure-free on antiepileptic drug (AED) monotherapy with appropriately selected first-line medication. In ideal world, physician is expected to achieve best possible seizure control without impacting the quality of life. There is rapid increase in number of AEDs available over last couple of decades. Although not necessarily all of them are superior to old generation drugs in terms of seizure control, certainly there is change in landscape from perspective of tolerability and side-effect profile. Physicians must therefore be familiar with safety, tolerability, therapeutic effects, synergistic combinations as well as AEDs to avoid in specific circumstances. The article attempts to give general overview of available AEDs under broad umbrella of effectiveness against focal and generalized seizures as well as drugs with “broad spectrum.” The emergence of newer AEDs with broad spectrum and favorable side-effect profile is welcome. However, the future lies in better understanding of underlying diverse pathophysiology of clinical symptom “epilepsy” and developing new compounds acting on molecular targets as well as individualizing therapy. Technological advances in molecular genetics research are bringing precision medicine to the fore.
Ramsay Hunt's Syndrome in Pediatric Age
Authors: Silva Marta Ribeiro , Leite Lídia , Sousa Filipa Peixoto , Maré Ricardo , Pontes Teresa 
Published: February 2021

AbstractThe Ramsay Hunt's syndrome (RHS), caused by the reactivation of the varicella-zoster virus (VZV), is an infrequent cause of peripheral facial palsy in the pediatric patients. A 16-year-old adolescent boy presented with headache, right earache, and signs of lower motor neuron type facial palsy. He was medicated with deflazacort. Four days later, he developed blurry vision in the right eye, gait imbalance, and vesicular lesions in the right ear with decreased ipsilateral hearing acuity. A diagnosis of RHS was considered. Cerebrospinal fluid (CSF) analysis showed pleocytosis, as well as VZV DNA. Magnetic resonance imaging of the brain identified abnormal uptake of gadolinium contrast in the right seventh cranial nerve, reinforcing the diagnosis. The patient was treated with acyclovir (14 days) and prednisone, with progressive clinical improvement. We emphasize the importance of recognizing this syndrome in patients with facial palsy, since the early antiviral treatment significantly improves the prognosis.
Wire Myography for Continuous Estimation of the Optimal Concentration of Topical Lidocaine as a Vasodilator in Microsurgery
Authors: Ogawa Haruo , Kusumoto Junya , Nomura Tadashi , Hashikawa Kazunobu , Terashi Hiroto , Sakakibara Shunsuke 
Published: January 2021

Abstract
Background Intraoperative vasospasm during reconstructive microvascular surgery is often unpredictable and may lead to devastating flap loss. Therefore, various vasodilators are used in reconstructive microsurgery to prevent and relieve vasospasm. Lidocaine is a vasodilator commonly used in microvascular surgery. Although many reports have described its in vitro and in vivo concentration-dependent vasodilatory effects, limited studies have examined the pharmacological effects of lidocaine on blood vessels in terms of persistence and titer.
Methods In this study, the vasodilatory effect of lidocaine was examined by using the wire myograph system. Abdominal aortas were harvested from female rats, sliced into rings of 1-mm thickness, and mounted in the wire myograph system. Next, 10, 5, 2, and 1% lidocaine solutions were applied to the artery, and the change in vasodilation force, persistence of the force, and time required to reach equilibrium were measured.
Results The vasodilatory effect was confirmed in all groups following lidocaine treatment. Although strong vasodilation was observed in the 10% lidocaine group, it was accompanied by irreversible degeneration of the artery. Vasodilation in the 1% lidocaine group was weaker than that in the other groups 500 seconds after lidocaine addition (p < 0.05). Between the 5 and 2% lidocaine groups, 5% lidocaine showed a stronger vasodilatory effect 400 to 600 seconds after lidocaine addition (p < 0.01); however, there was no significant difference in these groups after 700 seconds. Additionally, there was no difference in the time required for the relaxation force to reach equilibrium among the 5, 2, and 1% lidocaine groups.
Conclusion Although our study confirmed the dose-dependent vasodilatory effect of lidocaine, 5% lidocaine showed the best vasodilatory effect and continuity with minimal irreversible changes in the arterial tissue.
Laryngeal Mask Airway for Surfactant Administration Versus Standard Treatment Methods in Preterm Neonates with Respiratory Distress Syndrome: A Systematic Review and Meta-analysis
Authors: Al Ali Roqaia Ayesh , Gautam Bishal , Miller Michael R. , Coulson Sherry , Yuen Doris 
Published: January 2021

Objective Laryngeal mask airway (LMA) has emerged as an alternative surfactant delivery method. The effectiveness of this method for the delivery of surfactant is uncertain. A meta-analysis of randomized control trials (RCTs) comparing LMA with standard methods of surfactant delivery for the outcomes of surfactant dose repetition, oxygen requirement, mechanical ventilation, intubation, mortality, bronchopulmonary dysplasia (BPD), and pneumothorax.
Study Design Systematic review and meta-analysis of RCTs. Homogeneity between studies was analyzed by using I2 statistics. Risk ratio or mean difference of outcomes was assessed from random effects models. Subgroup analyses were conducted when necessary. Data sources are as follows: Ovid Medline, Embase, and the Cochrane Central Register of Controlled trials from inception till December 2018, bibliographies of identified reviews and trial registries for ongoing studies. RCTs comparing short-term respiratory outcomes in neonates with respiratory distress syndrome who were administered surfactant through an LMA versus standard method of care.
Results Six RCTs were identified, enrolling a total of 357 infants. Administering surfactant via LMA was associated with decreased FiO2 requirement (mean difference = 1.82 (95% confidence interval [CI]: −6.01–9.66), decreased intubation (risk ratio [RR] = 0.17; 95% CI: 0.05–0.57), and decreased mechanical ventilation (RR = 0.44; 95% CI: 0.31–0.61). There were no significant differences between groups for death, BPD, or pneumothorax.
Conclusion LMA might be an effective alternative method of surfactant delivery; however, further high-quality RCTs with larger sample size and including extreme preterm infants are needed to establish LMA as an alternative technique for surfactant delivery.
Key Points