bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sadness regulation strategies and measurement: A scoping review
Authors: Zaid Sumaia Mohammed , Hutagalung Fonny Dameaty , Bin Abd Hamid Harris Shah , Taresh Sahar Mohammed 
Published: August 2021

BackgroundsAccurate measurement and suitable strategies facilitate people regulate their sadness in an effective manner. Regulating or mitigating negative emotions, particularly sadness, is crucial mainly because constant negative emotions may lead to psychological disorders, such as depression and anxiety. This paper presents an overview of sadness regulation strategies and related measurement.MethodUpon adhering to five-step scoping review, this study combed through articles that looked into sadness regulation retrieved from eight databases.ResultsAs a result of reviewing 40 selected articles, 110 strategies were identified to regulate emotions, particularly sadness. Some of the most commonly reported strategies include expressive suppression, cognitive reappraisal, distraction, seeking social or emotional support, and rumination. The four types of measures emerged from the review are self-reported, informant report (parents or peers), open-ended questions, and emotion regulation instructions. Notably, most studies had tested psychometric properties using Cronbach’s alpha alone, while only a handful had assessed validity (construct and factorial validity) and reliability (Cronbach’s alpha or test-retest) based on responses captured from questionnaire survey.ConclusionSeveral sadness regulation strategies appeared to vary based on gender, age, and use of strategy. Despite the general measurement of emotion regulation, only one measure was developed to measure sadness regulation exclusively for children. Future studies may develop a comprehensive battery of measures to assess sadness regulation using multi-component method.
Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country
Authors: Ddungu Ahmed , Semitala Fred C. , Castelnuovo Barbara , Sekaggya-Wiltshire Christine , Worodria William , Kirenga Bruce J. 
Published: August 2021

Introduction
In the last decade, survival of people living with HIV (PLHIV) has dramatically increased due wide availability of effective antiretroviral therapy. However, PLHIV remain at a comparatively higher risk of non-communicable comorbidities. We sought to determine the burden of COPD and its associations in an urban tertiary HIV clinic in Uganda.

Methods and findings
HIV-infected adults attending the Makerere University Joint AIDS program; aged ≥30 years without acute ailments were screened for COPD using study questionnaires and spirometry (post-bronchodilator FEV1/FVC<0.7). We determined its prevalence and association with demographic characteristics, body mass index (BMI) and known risk factors.
Of 288 participants enrolled, 177 (61%) were female; 253 (88%) were from urban residences, median age was 45 years (IQR: 39–51), 71(25%) were ‘ever’ smokers, 284(99%) reported biomass fuel use and 72(25%) had a history of tuberculosis. All except 1 participant were on antiretroviral therapy, median current CD4 (cells/mm3) was 558 (IQR 402–753) and 275(96%) were virologically suppressed. Nearly half (130/288, 45%) had recurrent respiratory symptoms. The prevalence of COPD was 3.1% (9/288) [95% CI: 1.63–5.92]. COPD was associated with: previous tuberculosis, (adjusted odds ratio (AOR): 6.36, [95% CI 1.64–35.84], P = 0.036), self-reported chronic shortness of breath (AOR: 9.06, [95% CI 1.34–61.10], P = 0.024) and a BMI <21 Kg/m2 (AOR: 10.42 [95% CI: 1.61–100.00], P = 0.013).

Conclusion
In this HIV population, COPD prevalence was low and was associated with previous tuberculosis, self-reported chronic shortness of breath and BMI <21 Kg/m2.
Public perceptions and knowledge of cholesterol management in a multi-ethnic Asian population: A population-based survey
Authors: Lim Chiw Yeh , Ho Jien Sze , Huang Zijuan , Gao Fei , Tan Swee Yaw , Koh Woon Puay , Chua Terrance , Low Lip Ping , Tan Huay Cheem , Yoon Sungwon 
Published: August 2021

Introduction
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Hyperlipidemia is one of the important modifiable risk factors for CVDs. Raising public awareness of CVD risks is an important step in reducing CVD burdens. In this study, we aimed to assess public awareness and knowledge of cholesterol and its management in a multiethnic Asian population.

Methods
We recruited 1000 participants from three major ethnic groups for this nationwide population-based survey. A structured questionnaire was used to collect socio-demographics, knowledge of cholesterol and cholesterol-lowering medications. Univariate and multivariate analyses were conducted to identify factors associated with good knowledge on cholesterol and its management.

Results
Of the participants, 65% thought that high cholesterol produces symptoms and that lifestyle modification would be as effective as medication at lowering cholesterol. Nearly 70% believed that long term statin could lead to kidney or liver damage, and 56% thought that statin was associated with higher risk of cancer. A third saw herbal medicine or supplements as healthier and safer. About 45% believed that statin therapy should not be taken long term and that one could stop taking cholesterol medication when cholesterol is under control. Malays were more likely to have poor knowledge (adjusted OR 0.68; 95% CI 0.47–0.98; P = 0.039) compared to Chinese. Participants with intermediate education were more likely to have good knowledge of cholesterol and its management (adjusted OR 1.67; 95% CI 1.11–2.51; P = 0.013) compared to those with primary education.

Conclusion
Public knowledge and awareness of high cholesterol and its management remains poor in Asian multi-ethnic population. Understanding gaps in public knowledge can inform the implementation of health promotion programs to effectively raise awareness of cholesterol and its management.
Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART
Authors: Corley Michael J. , Sacdalan Carlo , Pang Alina P. S. , Chomchey Nitiya , Ratnaratorn Nisakorn , Valcour Victor , Kroon Eugene , Cho Kyu S. , Belden Andrew C. , Colby Donn , Robb Merlin , Hsu Denise , Spudich Serena , Paul Robert , Vasan Sandhya , Ndhlovu Lishomwa C. ,   the SEARCH010/RV254 and SEARCH013/RV304 study groups
Published: August 2021

HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis, viral persistence, and HIV-associated comorbidities. Here, we examined how soon after infection HIV-associated epigenetic changes may occur in blood and whether early initiation of antiretroviral therapy (ART) impacts epigenetic modifications. We profiled longitudinal genome-wide DNA methylation in monocytes and CD4+T lymphocytes from 22 participants in the RV254/SEARCH010 acute HIV infection (AHI) cohort that diagnoses infection within weeks after estimated exposure and immediately initiates ART. We identified monocytes harbored 22,697 differentially methylated CpGs associated with AHI compared to 294 in CD4+T lymphocytes. ART minimally restored less than 1% of these changes in monocytes and had no effect upon T cells. Monocyte DNA methylation patterns associated with viral load, CD4 count, CD4/CD8 ratio, and longitudinal clinical phenotypes. Our findings suggest HIV-1 rapidly embeds an epigenetic memory not mitigated by ART and support determining epigenetic signatures in precision HIV medicine.Trial Registration:NCT00782808andNCT00796146.
Prospective Evaluation of Endoscopic and Histologic Indices in Pediatric Ulcerative Colitis Using Centralized Review
Authors: Ricciuto Amanda , Carman Nicholas , Benchimol Eric I. , Siddiqui Iram , Putra Juan , Khanna Reena , Griffiths Anne M. , Walters Thomas D. , Church Peter C. 
Published: August 2021

INTRODUCTION:
We aimed to evaluate the reliability and validity of the Ulcerative Colitis (UC) Endoscopic Index of Severity (UCEIS) and Mayo Endoscopy Score (MES) and to validate the Robarts Histopathology Index (RHI) and Nancy Index (NI) in pediatric UC. We examined rectosigmoid and pancolonic versions of each instrument.

METHODS:
Single-center cross-sectional study of 60 prospectively enrolled participants. Through central endoscopy review, 4 pediatric gastroenterologists assigned rectosigmoid and pancolonic (mean of 5 colonic segments) UCEIS and MES scores. Two blinded pathologists assigned rectosigmoid and pancolonic RHI and NI scores. We assessed reliability with intraclass correlation coefficients and weighted kappa statistics and explored construct validity with correlations, boxplots, and receiver operator characteristic curves.

RESULTS:
The UCEIS and MES displayed almost perfect intra-rater and inter-rater reliability (intraclass correlation coefficient and weighted kappa ≥0.85), moderate-to-strong correlation with histologic/clinical activity and fecal calprotectin (FC), and very strong correlation with global endoscopic severity (r > 0.9). Rectosigmoid UCEIS and MES scores of 0 were highly specific (≥95%) for endoscopic and histologic remission throughout the colon. Pancolonic endoscopy scores correlated more strongly with histologic activity, clinical activity, and systemic inflammatory markers and better discriminated between degrees of active disease. RHI and NI showed moderate-to-strong correlation (r = 0.5–0.83) with endoscopic/clinical activity and FC.

DISCUSSION:
Our findings support the reliability and construct validity of the UCEIS and MES and the construct validity of the RHI and NI in pediatric UC. Normal rectosigmoid findings predicted pancolonic healing, but, given active disease, pancolonic endoscopic assessment more accurately captured global disease burden.
Prediction of Esophageal Retention: A Study Comparing High-Resolution Manometry and Functional Luminal Imaging Probe Panometry
Authors: Carlson Dustin A. , Baumann Alexandra J. , Prescott Jacqueline E. , Schauer Jacob M. , Krause Amanda , Donnan Erica N. , Kou Wenjun , Kahrilas Peter J. , Pandolfino John E. 
Published: August 2021

INTRODUCTION:
High-resolution manometry (HRM) is generally considered the primary method to evaluate esophageal motility; functional luminal imaging probe (FLIP) panometry represents a novel method to do so and is completed during sedated endoscopy. This study aimed to compare HRM and FLIP panometry in predicting esophageal retention on timed barium esophagram (TBE).

METHODS:
A total of 329 adult patients who completed FLIP, HRM, and TBE for primary esophageal motility evaluation were included. An abnormal TBE was defined by a 1-minute column height >5 cm or impaction of a 12.5-mm barium tablet. The integrated relaxation pressure (IRP) on HRM was assessed in the supine and upright patient positions. Esophagogastric junction (EGJ) opening was evaluated with 16-cm FLIP performed during sedated endoscopy through EGJ-distensibility index and maximum EGJ diameter.

RESULTS:
Receiver operating characteristic curves to identify an abnormal TBE demonstrated AUC (95% confidence interval) of 0.79 (0.75–0.84) for supine IRP, 0.79 (0.76–0.86) for upright IRP, 0.84 (0.79–0.88) for EGJ-distensibility index, and 0.88 (0.85–0.92) for maximum EGJ diameter. Logistic regression to predict abnormal TBE showed odds ratios (95% confidence interval) of 1.8 (0.84–3.7) for consistent IRP elevation and 39.7 (16.4–96.2) for reduced EGJ opening on FLIP panometry. Of 40 patients with HRM-FLIP panometry discordance, HRM-IRP was consistent with TBE in 23% while FLIP panometry was consistent with TBE in 78%.

DISCUSSION:
FLIP panometry provided superior detection of esophageal retention over IRP on HRM. However, application of a complementary evaluation involving FLIP panometry, HRM, and TBE may be necessary to accurately diagnose esophageal motility disorders.
Evaluating the Impact of Cost on the Treatment Algorithm for Chronic Idiopathic Constipation: Cost-Effectiveness Analysis
Authors: Shah Eric D. , Staller Kyle , Nee Judy , Ahuja Nitin K. , Chan Walter W. , Lembo Anthony , Brenner Darren M. , Siegel Corey A. , Chey William D. 
Published: August 2021

INTRODUCTION:
Chronic idiopathic constipation (CIC) is a common and burdensome illness. We performed a cost-effectiveness analysis of the US Food and Drug Administration–approved CIC drugs to evaluate and quantify treatment preferences compared with usual care from insurer and patient perspectives.

METHODS:
We evaluated the subset of patients with CIC and documented failure of over-the-counter (OTC) osmotic or bulk-forming laxatives. A RAND/UCLA consensus panel of 8 neurogastroenterologists informed model design. Treatment outcomes and costs were defined using integrated analyses of registered clinical trials and the US Centers for Medicare and Medicaid Services–supported cost databases. Quality-adjusted life years (QALYs) were calculated using health utilities derived from clinical trials. A 12-week time horizon was used.

RESULTS:
With continued OTC laxatives, CIC-related costs were $569 from an insurer perspective compared with $3,154 from a patient perspective (considering lost wages and out-of-pocket expenses). CIC prescription drugs increased insurer costs by $618–$1,015 but decreased patient costs by $327–$1,117. Effectiveness of CIC drugs was similar (0.02 QALY gained/12 weeks or ∼7 healthy days gained/year). From an insurer perspective, prescription drugs (linaclotide, prucalopride, and plecanatide) seemed less cost-effective than continued OTC laxatives (incremental cost-effectiveness ratio >$150,000/QALY gained). From a patient perspective, the cost-effective algorithm started with plecanatide, followed by choosing between prucalopride and linaclotide starting at the 145-μg dose (favoring prucalopride among patients whose disease affects their work productivity). The patient perspective was driven by drug tolerability and treatment effects on quality of life.

DISCUSSION:
Addressing costs at a policy level has the potential to enable patients and clinicians to move from navigating barriers in treatment access toward truly optimizing treatment choice.
Commentary—Extending the Boundaries of Systematic Case Study Research: Conceptual and Methodological Issues
Authors: Elliott Robert , Stephen Susan , Robinson Anna 
Published: August 2021

In this commentary we discuss the two examples of systematic case study research in this issue: Miller et al., (2021), who continue the development of the quasi-judicial Panels of Psychological Inquiry method by applying it to a child client with an autistic spectrum condition; and Bohart et al. (2021), who apply their research jury approach to a video recorded case of Emotionally-Focused Therapy for couples. We open by briefly summarizing the main issues addressed in our previous commentary (Stephen & Elliott, 2011), which involved the same authors; we also note some key developments in systematic case study research over the past ten years. The rest of our commentary is divided into three parts. First, we look at more general conceptual issues in systematic case study research, including situations in which systematic case studies are likely to be most useful; the problem of overly broad research questions; the definition and assessment of outcome; and the thorny issue of causality. In the second part, we turn our attention to methodological issues raised by the two articles, returning to the questions of what counts as evidence in systematic case study research (here the use of observational methods for assessing client change and change processes), but also to the processes by which research judges or jurors make decisions about knowledge claims and methods for generalizing from one case to other cases. In the final main section, we offer more substantive commentary on Miller et al. (2021), from the point of view of autism research. We start by putting the DIR/Floortime intervention in context before raising key diagnostic issues that we think circumscribe the case and spelling out uncertainties about the nature of the intervention used. We round off this section with a set of proposals for future systematic single case research on interventions for autism. We close our commentary with a brief set of recommendations.
Alternative detection of SARS-CoV-2 RNA by a new assay based on mass spectrometry
Authors: Stelzl Evelyn , Kessler Harald H. , Mustafa Hans G. , Mustafa Maria E. , Santner Brigitte I. , Seier Josef , La Torre Marco , Haushofer Alexander C. 
Published: August 2021

Abstract

Objectives
Accurate detection of SARS-CoV-2 RNA is essential to stopping the spread of SARS-CoV-2. The aim of this study was to evaluate the performance of the recently introduced MassARRAY® SARS-CoV-2 Panel and to compare it to the cobas® SARS-CoV-2 Test.

Methods
The MassARRAY® SARS-CoV-2 Panel consists of five assays targeting different sequences of the SARS-CoV-2 genome. Accuracy was determined using national and international proficiency panels including 27 samples. For clinical evaluation, 101 residual clinical samples were analyzed and results compared. Samples had been tested for SARS-CoV-2 RNA with the cobas® SARS-CoV-2 Test.

Results
When accuracy was tested with the MassARRAY® SARS-CoV-2 Panel, 25 of 27 (92.6%) samples revealed correct results. When clinical samples were analyzed with the MassARRAY® SARS-CoV-2 Panel and compared to the cobas® SARS-CoV-2 Test, 100 samples showed concordant results. One sample was found to be inconclusive with the MassARRAY® SARS-CoV-2 Panel. When time-to-results were compared, the new assay showed longer total and hands-on times.

Conclusions
The MassARRAY® SARS-CoV-2 Panel showed a good performance and proved to be suitable for use in the routine diagnostic laboratory. Especially during phases of shortage of reagents and/or disposables, the new test system appears as beneficial alternative to standard assays used for detection of SARS-CoV-2 RNA.
Consideration should be given to smoking, endometriosis, renal function (eGFR) and age when interpreting CA125 and HE4 in ovarian tumor diagnostics
Authors: Lycke Maria , Ulfenborg Benjamin , Malchau Lauesgaard Jacob , Kristjansdottir Björg , Sundfeldt Karin 
Published: August 2021

Abstract

Objectives
To evaluate the impact of different biologic, histopathologic and lifestyle factors on serum levels of human epididymis protein 4 (HE4) and Cancer antigen 125 (CA125) in the diagnostic work up of women with an ovarian cyst or pelvic tumor.

Methods
The statistical evaluation was performed on a population of 445 women diagnosed with a benign ovarian disease, included in a large Swedish multicenter trial (ClinicalTrials.gov NCT03193671). Multivariable logistic regression analyses were performed to distinguish between the true negatives and false positives through adjusting for biologic, histopathologic and lifestyle factors on serum samples of CA125 and HE4 separately. The likelihood ratio test was used to determine statistical significance and Benjamini-Hochberg correction to adjust for multiple testing.

Results
A total of 31% of the women had false positive CA125 but only 9% had false positive results of HE4. Smoking (OR 6.62 95% CI 2.93–15.12) and impaired renal function, measured by eGFR (OR 0.18 95% CI 0.08–0.39), were independently predictive of falsely elevated serum levels of HE4. Endometriosis was the only variable predictive of falsely elevated serum levels of CA125 (OR 7.96 95% CI 4.53–14.39). Age correlated with increased serum levels of HE4.

Conclusions
Smoking, renal failure, age and endometriosis are factors that independently should be considered when assessing serum levels of HE4 and CA125 in women with an ovarian cyst or pelvic mass to avoid false indications of malignant disease.
Singularity analysis of a 7-DOF spatial hybrid manipulator for medical surgery
Authors: Gupta Sameer , Singla Ekta , Soni Sanjeev , Singla Ashish 
Published: August 2021

Abstract
This paper presents the singularity analysis of a 7-degrees of freedom (DOF) hybrid manipulator consisting of a closed-loop within it. From the past studies, it is well-known that the kinematic singularities play a significant role in the design and control of robotic manipulators. Kinematic singularities pose two-fold effects – first, they can induce the loss of one or more DOF of the manipulator and cause infinite joint rates at that particular joint, and second, they help to determine the trajectory or zone with high mechanical advantage. In current work, a 7-DOF hybrid manipulator is considered which is being developed at Council Of Scientific And Industrial Research–Central Scientific Instruments Organisation (CSIR–CSIO) Chandigarh to assist a surgeon during a medical-surgical task. To emulate the natural motion of a surgeon, the challenging configuration with redundant DOF is utilized. Jacobian has been computed analytically and analyzed at each instantaneous configuration with the evaluation of manipulability. Effect of a closed loop in the hybrid configurations is focused at, and utilizing the contour plots, good and worst working zones are identified in the workspace of the manipulator. The verification and validation of best and worst manipulability points (singularities) are done with the help of genetic algorithms, to determine locally and globally optimal configurations. Finally, on the basis of the singularity analysis, the present work concludes with few guidelines to the surgeon about the best and worst working zones for surgical tasks.
Playful Curation: A Case Study of Doki-Doki Station Museum’s Role in Preserving Digital Game History in Indonesia
Authors: Jiwandono Haryo Pambuko , Purwandi Edeliya Relanika 
Published: August 2021

Abstract
Digital game preservation is a key element in framing the historical importance of digital game culture. Digital game preservation processes in the global north, particularly in countries such as the United States and the United Kingdom, is well documented because of a well-established game culture. By contrast, digital game preservation in the global south is not as well documented because of the peripheral nature of game culture in those societies. This article seeks to correct this imbalance by asserting the importance of digital game preservation in two ways. First, digital game culture is situated in local practices and culture while acknowledging its near-global presence. Second, we argue that digital games need to be understood as localized formative elements of culture. Our discussion focuses on the Doki-Doki Station Museum located in Bandung, West Java, Indonesia.
Potential predators of Dolichotis patagonum in the surroundings of its burrows, in Sierra de las Quijadas National Park, San Luis, Argentina
Authors: Gatica Ailin , Ochoa Ana C. , Mangione Antonio M. 
Published: August 2021

Abstract

Dolichotis patagonum (common name: mara) is a large sized rodent, endemic of Argentina, which raises its juveniles in burrows. It has recently been categorized as vulnerable. This is the first study to evaluate D. patagonum interactions with potential predators in the surroundings of the dens. We monitored 20 burrows, using camera-traps, with a total of 5644 camera-days, obtained over two years (2015 and 2016). Five potential predator species were detected (Lycalopex griseus, Puma concolor, Leopardus geoffroyi, Salvator sp. and Chaetophractus villosus). L. griseus and L. geoffroyi were the species with the highest frequency of visits. Both species were photographed attacking the juveniles. Four out of five potential predator species registered presented agonistic interactions with adults of mara. Overlap between all species analyzed and mara was low to moderate, and potential predator visits to the surrounding of the burrows did not vary according to the presence of juveniles. Our results suggest that in this system, predators behave as opportunistic predators of mara’s juveniles. Mara’s social and reproductive behavior varies along the distribution range of the species, therefore it is of great ecological value to analyze and understand the variations of its interactions with predators in different regions and environments.