bluuebunny/crossref_metadata_2025_split huggingface dataset:
An advanced hybrid algorithm for nonlinear function optimization with real world applications
Authors: Verma Pooja , Parouha Raghav Prasad 
Published: August 2021

SummaryThis article presents an advanced hybrid algorithm (haDEPSO) for nonlinear constrained function optimization problem. It consists of the advised advanced differential evolution, that is, aDE (wherein a novel mutation, crossover, and selection strategy is introduced, to avoid premature convergence) and particle swarm optimization, namely, aPSO (in which novel gradually varying parameters is utilized, to escape stagnation). The proposedhaDEPSO achieve better results as aDE and aPSO provides diverse convergence characteristic to the solution space. Moreover, inhaDEPSO distinct population is merged with other in a predefined way, to balance between exploration and exploitation. Efficiency of the proposed hybridhaDEPSO along with its integrating component aDE and aPSO are inspected on IEEE CEC'2006 constrained benchmark functions and IEEE CEC'2011 real world problems. According to the comparison results, the proposed methods achieved better results than traditional DE and PSO with their hybrids as well as over many state‐of‐the‐art algorithms.
Investigation of Factors Associated With Immunogenicity Labeling Updates and Characteristics of Biologics License Applications
Authors: Jiang Ai‐Lei , Breder Christopher D. , Chang Lin‐Chau 
Published: August 2021

Immunogenicity, the potential to elicit an antidrug immune response, is a critical concern in developing biological products, but its consequences are difficult to predict with animal studies. The aims of the present study are to investigate the evolution of immunogenicity information in labeling and to identify attributes associated with immunogenicity labeling updates. Biologics License Applications (BLAs) approved by the Center for Drug Evaluation and Research, US Food and Drug Administration between 2008 and 2017 were studied. A majority of BLAs described the incidence/prevalence of antidrug antibodies (ADAs) (94.9%) and neutralizing antibodies (NAbs) (68.4%) in their original labeling documents. However, less than one third of the BLAs mentioned the impact of ADAs/NAbs in the original (20.3%) and most recent (29.1%) labeling documents. BLAs with a priority review status (57.4% vs. 33.3%), orphan designation (61.5% vs. 34.2%), or a mention of ADA impact in the latest label (69.6% vs. 38.9%) had higher percentages of applications with postmarketing requirements (PMRs) directly related to immunogenicity concerns in comparison with applications without those characteristics. Among the BLAs with updated immunogenicity information, the mean time to the first update was 1,077 days, while that for BLAs with accelerated approval was shorter (709.1 ± 492.2 days vs. 1173.8 ± 661.8 days). The results suggest that there is a substantial amount of critical information lacking in the original labeling documents and an overdependence on PMRs for more evidence. Additional efforts should be made to investigate the impact of ADAs to provide timely information for improved patient care.
Effect of Intralipid infusion on peripheral blood T cells and plasma cytokines in women undergoing assisted reproduction treatment
Authors: Foyle Kerrie L , Sharkey David J , Moldenhauer Lachlan M , Green Ella S , Wilson Jasmine J , Roccisano Cassandra J , Hull M Louise , Tremellen Kelton P , Robertson Sarah A 
Published: August 2021

AbstractObjectivesIntravenous infusion of Intralipid is an adjunct therapy in assisted reproduction treatment (ART) when immune‐associated infertility is suspected. Here, we evaluated the effect of Intralipid infusion on regulatory T cells (Treg cells), effector T cells and plasma cytokines in peripheral blood of women undertaking IVF.MethodsThis prospective, observational pilot study assessed Intralipid infusion in 14 women exhibiting recurrent implantation failure, a clinical sign of immune‐associated infertility. Peripheral blood was collected immediately prior to and 7 days after intravenous administration of Intralipid. Plasma cytokines were measured by Luminex, and T‐cell subsets were analysed by flow cytometry.ResultsA small increase in conventional CD8+ T cells occurred after Intralipid infusion, but no change was seen in CD4+ Treg cells, or naïve, memory or effector memory T cells. Proliferation marker Ki67, transcription factors Tbet and RORγt, and markers of suppressive capacity CTLA4 and HLA‐DR were unchanged. Dimensionality‐reduction analysis using the tSNE algorithm confirmed no phenotype shift within Treg cells or other T cells. Intralipid infusion increased plasma CCL2, CCL3, CXCL8, GM‐CSF, G‐CSF, IL‐6, IL‐21, TNF and VEGF.ConclusionIntralipid infusion elicited elevated pro‐inflammatory cytokines, and a minor increase in CD8+ T cells, but no change in pro‐tolerogenic Treg cells. Notwithstanding the limitation of no placebo control, the results do not support Intralipid as a candidate intervention to attenuate the Treg cell response in women undergoing ART. Future placebo‐controlled studies are needed to confirm the potential efficacy and clinical significance of Intralipid in attenuating cytokine induction and circulating CD8+ T cells.
Environmental DNA as a detection and quantitative tool for stream‐dwelling salamanders: A comparison with the traditional active search method
Authors: Plante Félix , Bourgault Patrice , Dubois Yohann , Bernatchez Louis 
Published: August 2021

AbstractAs amphibians are showing significant signs of decline, adequate information and understanding of target species are essential for taking appropriate conservation measures. In recent years, environmental DNA has seen notable growth as a monitoring tool and testing this emergent method with various species has become an important step toward a better understanding of its benefits and limits for studying specific taxa. This study focused on using species‐specific qPCR assays developed in our research group to test the eDNA method for three stream‐dwelling salamander species of the Plethodontidae family: the Spring salamander (Gyrinophilus porphyriticus), the Northern dusky salamander (Desmognathus fuscus), and the Northern two‐lined salamander (Eurycea bislineata). The traditional active search method and the eDNA method were compared for both their ability to detect species as well as to provide a quantitative assessment of populations in 24 headwater streams in Québec, eastern Canada. For all three species, eDNA was detected in every stream where the target species was observed during the active search method. Moreover, eDNA was detected in nine streams where the target species was not identified with the active search. A marginally significant association was found between eDNA concentration and salamander density for D. fuscus only. All species showed high variability for eDNA concentration between qPCR technical replicates and between samples of a given stream. The results of this study lead us to conclude that eDNA can be an excellent method for detection of stream‐dwelling salamanders. Given the inconsistent quantitative aspect of eDNA with the studied species, the future of these stream‐dwelling salamander monitoring most likely lies in the combined use of both eDNA and active search methods. Hence, active search could continue to offer useful small‐scale detection and reliable quantitative data while eDNA could be implemented as an efficient and promising tool for large‐scale detection.
Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective
Authors: Ahmed Fozia Z. , Taylor Joanne K. , John Anju V. , Khan Muhammad A. , Zaidi Amir M. , Mamas Mamas A. , Motwani Manish , Cunnington Colin 
Published: August 2021

AbstractAimsThis study aims to establish the feasibility, safety, and efficacy of outpatient intravenous (IV) diuretic treatment for the management of decompensated heart failure (HF) for patients enrolled in the HeartFailure@Home service.Methods and resultsWe retrospectively analysed the clinical episodes of decompensated HF for patients enrolled in the HeartFailure@Home service, managed by ambulatory IV diuretic treatment either at home or on a day‐case unit. A control group consisting of HF patients admitted to hospital for IV diuretics (standard‐of‐care) was also evaluated. In total, 203 episodes of decompensated HF (n = 154 patients) were evaluated. One hundred and fourteen episodes in 79 patients were managed exclusively by the ambulatory IV diuretic service—78 (68.4%) on a day‐case unit and 36 (31.6%) domiciliary; 84.1% of patient episodes under the HF@Home service were successfully managed entirely in an out‐patient setting without hospitalization. Eleven patients required admission in order to administer higher doses of IV diuretics than could be provided in the ambulatory setting. During follow‐up, there were 20 (17.5%) 30 day re‐admissions with HF or death in the ambulatory IV group and 29 (32.6%) in the standard‐of‐care arm (P = 0.02). There was no difference in 30 day HF readmissions between the two groups (14.9% ambulatory vs. 13.5% inpatients, P = 0.8), but 30 day mortality was significantly lower in the ambulatory group (3.5% vs. 21.3% inpatients, P < 0.001).ConclusionsOutpatient ambulatory management of decompensated HF with IV diuretics given either on a day case unit or in a domiciliary setting is feasible, safe, and effective in selected patients with decompensated HF. This should be explored further as a model in delivering HF services in the outpatient setting during COVID‐19.
When NO. Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO. and HNO Donors for Old and Current Medical Issues
Authors: Muniz Carvalho Edinilton , Silva Sousa Eduardo Henrique , Bernardes‐Génisson Vania , Gonzaga de França Lopes Luiz 
Published: August 2021

AbstractNitric oxide (NO.) has been widely studied as an active agent of many physiological and pathological processes. Currently, NO. divides attention with its sibling molecule, nitroxyl (HNO), mainly due to their differences in physiological responses broadening their applications. In order for NO. and HNO to have their multiple biological effects, they must reach quite specific concentrations in the body. This key issue makes it essential to develop strategies for delivering these molecules in a controlled and selective manner. The wide range of activities of these compounds along with smart strategies in the development of NO./HNO donors have made them a hot spot. There are some NO. donor strategies in clinical use and also others in clinical trial, while HNO donors are further behind, illustrating the opportunities to come. Along these lines, we reviewed some current exciting NO. and HNO donor species, including organic‐ and inorganic‐based compounds, as well as nanomaterial platforms and NO. donor devices. This update may provide an overview of the systems currently available and how far we have come to meet multiple pharmacological needs.
Copper(II)‐Assisted Ammonia Borane Dehydrogenation: An Insight
Authors: Mounika Siripurapu , Krishnaveni Valle , Dmello Marilyn Esclance , Kalidindi Suresh Babu 
Published: August 2021

AbstractAmine boranes are in limelight in recent times as they have been considered as one of the potential candidates for on‐board hydrogen storage. Among various amine boranes, Ammonia borane (AB, 19.6 wt % H) with hydridic (B−H) and protic (N−H) hydrogens on adjacent atoms is the most studied molecule. From the past decade, as the chemists try to develop effective catalysts for the release of hydrogen from AB, simultaneously new interesting chemistry of AB has been evolved. These studies increased the scope of AB for other applications such as in the synthesis of nanoparticles, as transfer hydrogenation agent, in organic synthesis, etc. Here we focus on Cu2+‐AB system in water and organic solvents (THF/diglyme) to unveil new chemistry. CuCl2 readily reacted with AB in both media to generate H2 and Cu2+ was reduced to Cu(0) when AB is present in excess. We got an insight into these reactions by carrying out reactions for various Cu2+/AB mole ratios and characterizing the reaction mixtures with 11B NMR spectroscopy. The copper products were identified by powder X‐ray diffraction technique. We noticed the formation of CuH and CuCl intermediates upon B−H bond scission by Cu2+.
Electrochemical Direct Thiolation of Lactams with Mercaptans: An Efficient Access to N‐Acylsulfenamides
Authors: Wei Zhaoxin , Wang Renjie , Zhang Yonghong , Wang Bin , Xia Yu , Abdukader Ablimit , Xue Fei , Jin Weiwei , Liu Chenjiang 
Published: August 2021

AbstractAn efficient and eco‐friendly electrochemical methodology for the oxidative cross coupling hydrogen evolution (CCHE) reactions of lactams with thiols is presented. Various electron deficient N‐acylsulfenamides are smoothly produced in modest to excellent yields without using any external oxidant. Elementary mechanistic insight supports a possible free radical process and hydrogen is the only side product. This approach provides a safe, convenient, and economical preparation of synthetically important N‐thiophthalimides on a gram scale.
Ferroic alternation in methylammonium lead triiodide perovskite
Authors: Qin Shengjian , Yi Shenghui , Xu Yanqing , Mi Zhou , Zhao Jinjin , Tian Xiaobao , Guo Huajun , Jiao Yinan , Zhang Guanglei , Lu Jian 
Published: August 2021

AbstractMethylammonium lead triiodide (MAPbI3) perovskite has attracted broad interest for solar cells, light‐emitting diodes, and so forth. Experiments have captured that the alternative coexistence of polar and nonpolar domains in MAPbI3 can be switched by photons and phonons. Therefore, it is urgent to clarify the interplay among the crystal space group, polarity, ferroic properties, and switching mechanisms for MAPbI3. Herein, we perform a statistical synthesis on ferroelectric and anti‐ferroelectric features for tetragonal MAPbI3 perovskite. The polar and nonpolar domains are ferroelectric with the I4cm space group and anti‐ferroelectric with the I4/mcm space group, respectively. The domain wall (DW) separating nonpolar and polar regions is charged. Combining the effects of the electric properties of ferroic domains and the charged DWs, novel switching mechanisms are proposed in which photons and phonons drive alternations between ferroelectric and anti‐ferroelectric domains, which provide a reasonable approach to clarify the ambiguous understanding of ferroic behavior for MAPbI3 perovskite.image
In‐depth exploration into China's industrial park air monitoring market
Authors: Zhang Weimin , Zhang Mengying 
Published: August 2021

AbstractIn different regions of China that can range from 5 to 100 km2, various production plants and facilities such as petrochemicals, pesticides, pharmaceuticals, paper mills, thermal power plants, hazardous waste disposal sites makes chemical industrial parks with Chinese characteristics. At the same time, these chemical industry parks in various places are in urgent need of advanced monitoring, prewarning, and tracing technologies, in order to strengthen monitoring of atmospheric emissions in chemical industrial parks, and timely prevention of the leakage of exhaust gas and explosion accidents in the production process of these enterprises. Most of the Chinese chemical industry parks still use traditional air monitoring technologies that requires setting up passive air monitoring collection points at the boundary of enterprises and industrial parks and use the “point” sensor and pollution factors collected by air stations. However, the operation of traditional air monitoring equipment is affected by the prevailing wind conditions, thus the traditional air monitoring equipment and technology is of limited use to conduct monitoring. One of the authors of this manuscript, Weimin Zhang with Jiangsu China‐U.S. Environmental Monitoring Co. Ltd. (hereinafter referred to as EMCUS), with 10 years of has been testing and observing air diffusion law in chemical industrial parks for 10 years and has achieved fruitful success. The best way to truly achieve tracing and prewarning about the air pollution is to conduct timely three‐dimensional dynamic collection of chemical factors and then perform qualitative and quantitative analysis. Based on this theory, EMCUS has abandoned the traditional “point” passive monitoring theories. After a comprehensive analysis and comparison of air quality monitoring technology and equipment around the world, especially several investigations of advanced Fourier transform infrared spectroscopy (FTIR) equipment and software in the United States, EMCUS initiated the three‐dimensional monitoring technology for exhaust gas emissions which fully combined with the current situations of chemical industry parks. During the EcoPartnership project, the stepwise vertical and radial air monitoring technology was fully promoted in Chinese chemical industry parks to generate key emission data.
Model updating method for hybrid simulation based on global sensitivity analysis
Authors: Zhong Weipeng , Chen Zaixian 
Published: August 2021

AbstractThe hybrid simulation (HS) is a cost‐effective and promising method for investigating the seismic performance of structures. This paper proposes a model updating method for HS to improve incomplete boundary conditions and model error, and develops criteria to select the updated parameters. First, an actual HS model updating is conducted to verify the effectiveness of uniform design as a parameter estimation method. This experiment shows that parameter sensitivity has a significant relationship with the update effect. Then, the Sobol global sensitivity analysis (GSA) method is applied to the HS model updating to obtain the sensitivity indices of parameters that change with time, which provides a sound basis for parameter selection and the determination of the search range. Following this, a whole‐structure module for dynamic time history analysis is proposed to improve the boundary conditions, simplify the implementation, and refine the numerical models. The errors in six boundary conditions of the traditional HS are then analyzed. The proposed method of model updating based on GSA is then obtained by integrating the above ideas. In the case of multiple inputs of ground motion, four strategies are developed to verify the effectiveness of the method. The results of a total of 216 numerical cases under different working conditions show that the proposed method can improve the accuracy of HSs and the identified parameters.
Effects of using phase change material and non‐Newtonian power law nanofluid on different sides of a double pipe heat exchanger for phase change dynamics and energy performance improvements
Authors: Selimefendigil Fatih , Öztop Hakan F. 
Published: August 2021

AbstractIn this study, the effects of using phase change material (PCM) and non‐Newtonian power law (PL) fluid on the performance features of a double pipe heat exchanger were numerically assessed with finite element technique. PCM and PL fluid were used in different sides of the heat exchanger while impacts of cold side fluid Re number, nanoparticles loading amount, and PL index of fluid on the dynamics characteristics of phase change process, and thermal performance were examined. There is a reduction of 71.5% in the full phase transition time (td) when cases with Re = 100 and Re = 300 are compared while cold fluid exit temperature rises by about 5.8 K with PCM‐installed heat exchanger as compared to non‐PCM configuration at Re = 300. As cases with different PL indices (n) between n = 0.8 and n = 1.2 are compared, the value of td rises by about 34%. For different nanoparticle loading, variation of td depends upon the PL index and its value rises with higher n at the highest solid volume fraction. The particle size has also impacts on the variation of td and exit temperatures which is more pronounced for power n values. A polynomial regression model is used for the estimation of td.
Myricetin: A comprehensive review on its biological potentials
Authors: Imran Muhammad , Saeed Farhan , Hussain Ghulam , Imran Ali , Mehmood Zaffar , Gondal Tanweer Aslam , El‐Ghorab Ahmed , Ahmad Ishtiaque , Pezzani Raffaele , Arshad Muhammad Umair , Bacha Umar , Shariarti Mohammad Ali , Rauf Abdur , Muhammad Naveed , Shah Zafar Ali , Zengin Gokhan , Islam Saiful 
Published: August 2021

AbstractMyricetin is a critical nutritive component of diet providing immunological protection and beneficial for maintaining good health. It is found in fruits, vegetables, tea, and wine. The families Myricaceae, Polygonaceae, Primulaceae, Pinaceae, and Anacardiaceae are the richest sources of myricetin. Different researchers explored the therapeutic potential of this valuable constituent such as anticancer, antidiabetic, antiobesity, cardiovascular protection, osteoporosis protection, anti‐inflammatory, and hepatoprotective. In addition to these, the compound has been tested for cancer and diabetic mellitus during clinical trials. Health benefits of myricetin are related to its impact on different cell processes, such as apoptosis, glycolysis, cell cycle, energy balance, lipid level, serum protein concentrations, and osteoclastogenesis. This review explored the potential health benefits of myricetin with a specific emphasis on its mechanism of action, considering the most updated and novel findings in the field.
Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID‐19: A retrospective cohort study
Authors: Chen Shanquan , Jones Peter B. , Underwood Benjamin R. , Fernandez‐Egea Emilio , Qin Pei , Lewis Jonathan R. , Cardinal Rudolf N. 
Published: August 2021

AbstractObjectiveTo investigate factors contributing to excess deaths of older patients during the initial 2020 lockdown beyond those attributable to confirmed COVID‐19.MethodsRetrospective cohort study comparing patients treated between 23 March 2020 and 14 June 2020, deemed exposed to the pandemic/lockdown, to patients treated between 18 December 2019 and 10 March 2020, deemed to be unexposed. Data came from electronic clinical records from secondary care mental health services in Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), UK (catchment area population ∼0.86 million). Eligible patients were aged 65 years or over at baseline with at least 14 days' follow‐up, excluding patients diagnosed with confirmed or suspected SARS‐CoV‐2 infection. The primary outcome was all‐cause mortality.FindingsIn the two cohorts, 3,073 subjects were exposed to lockdown and 4,372 subjects were unexposed; the cohorts were followed up for an average of 74 and 78 days, respectively. After controlling for confounding by sociodemographic factors, smoking status, mental comorbidities, and physical comorbidities, patients with dementia suffered an additional 53% risk of death (HR = 1.53, 95% CI = 1.02–2.31), and patients with severe mental illness suffered an additional 123% risk of death (HR = 2.23, 95% CI = 1.42–3.49). No significant additional mortality risks were identified from physical comorbidities, potentially due to low statistical power in that respect.ConclusionDuring lockdown people with dementia or severe mental illness had a higher risk of death without confirmed COVID‐19. These data could inform future health service responses and policymaking to help prevent avoidable excess death during future outbreaks of this or a similar infectious disease.