bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dispensing patterns of drugs used for neuropathic pain and adherence to NeuPSIG guideline: an observational study
Authors: Chahine Bahia , Al Souheil Farah 
Published: October 2021

Abstract
Background
Neuropathic pain is a common chronic ailment that can be challenging to treat because of the heterogeneity of its etiologies, symptoms, and underlying mechanisms. Drugs to treat neuropathic pain are highly prescribed; however, limited data exist on the rates and patterns of dispensing in Lebanon. This study was conducted to assess the patterns of dispensing neuropathic pain drugs and adherence to NeuPSIG guideline in the Lebanese adult population. An observational study was conducted at 30 community pharmacies over 10 months. Adults presenting to the community pharmacy with a prescription of at least one pain medication and diagnosed with a neuropathic pain disorder were interviewed using a questionnaire that included demographic characteristics of patients, comorbidities, neuropathic pain disorder type, physicians’ specialty, and the class and number of prescribed medications.

Results
A total of 360 patients diagnosed with painful neuropathy were enrolled in our study. The mean patients’ age was 50.2 years. Guideline-recommended first-line agents (serotonin–norepinephrine reuptake inhibitors, tricyclic antidepressants, and gabapentinoids) were prescribed to 278 patients (77.2%), with pregabalin being the most used drug (60.5%), nonsteroidal anti‐inflammatory drugs (46.8%), opioids (15.8%), and topical agents (5.5%). Combination treatment for neuropathic pain was prescribed to 78.3% of patients.

Conclusions
In Lebanon, neuropathic pain management comply with the international NeuPSIG guideline. Pregabalin is the most commonly used drug, and combination treatments are usually needed to alleviate neuropathic pain.
A systematic review of in-patients’ antimicrobial prescriptions and status of antimicrobial stewardship programmes in Nigerian hospitals
Authors: Iheanacho Chinonyerem O. , Eze Uchenna I. H. 
Published: October 2021

Abstract
Background
Antimicrobial resistance is a major consequence of irrational antimicrobial prescriptions and consumptions, but this can be prevented by antimicrobial stewardship. The study systematically reviewed available evidence on antimicrobial prescriptions and antimicrobial stewardship (AMS) programmes in Nigerian hospitals. This will provide insight to the extent of required interventions, for improved healthcare.

Main body
Published research from January 1 2010 to March 31 2021 from PubMed, Scopus, Web of Science, African Journals Online and Google scholar databases was reviewed using Preferred Regulatory Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines 2009. Studies that reported antimicrobial use and antimicrobial stewardship programmes in Nigerian hospitals within the period in focus were assessed for eligibility. The National Heart, Lung and Blood Institute (NHLBI) quality assessment tool was used to assess quality of included studies. Among 15 studies included based on inclusion criteria, 12 reported on antimicrobial prescriptions and 3 reported on status of antimicrobial stewardship programmes in Nigerian hospitals. Most studies reported high prevalence of antimicrobials prescriptions with broad spectrum antimicrobials, majority of which were inappropriate. Empirical antimicrobial prescribing was common, and this was mostly done with less cognisance to existing guidelines. Only few hospitals were observed to have formal AMS teams in Nigeria.

Conclusion
Inappropriate prescribing of antimicrobials was common among prescribers in Nigeria. Although there was paucity of studies on status of AMS, the available few showed very low prevalence of AMS teams in hospitals. There is urgent need for implementation of AMS in Nigerian hospitals, to enhance rational antimicrobial use. Meanwhile more research on AMS in Nigerian hospitals is needed.
Correlation between sit-to-stand ability, dynamic balance, gait speed, and quality of life in stroke population: a non-randomized pilot study
Authors: Azharuddin Muhammad , Zia Nayeem U. 
Published: October 2021

Abstract
Background
“Sit to stand” being a prerequisite for walking, the inability of patients to perform it can result in institutionalization, impaired functioning and mobility in activities of daily living. There was a need to find out whether “sit to stand” ability correlates with gait speed, dynamic balance, and quality of life in stroke patients. It is a pilot study in which sixteen sub-acute and chronic stroke (˃ 6 months) patients aged 45 to 65 years with the ability to walk at least 10 m, Mini Mental State Examination (MMSE) score ˃ 27 were included. Patients with musculoskeletal impairments of lower extremity which would affect walking were excluded from the study. Each patient performed five times sit to stand (5TSTS) from a standard chair and time taken was recorded. Timed up and go (TUG) test and 10-m walk test (10MWT) were used to measure the dynamic balance and gait speed respectively. Stroke Adapted Sickness Impact Profile-30 (SASIP-30) scale was used to determine the quality of life of the patients.

Results
Correlation between the outcomes of the variables was analyzed using Pearson correlation co-efficient. The 5TSTS scores showed strong positive correlation to TUG (r = 0.823, P < .000) and SASIP-30 (r = 0.841, P < .000). However, moderately strong negative relationship was found between 5TSTS and gait speed (r = −0.639, P < .008).

Conclusion
The study concludes that change in the 5TSTS performance can affect motor functions like dynamic balance and gait as well as quality of life. Exercise training focusing on sit-to-stand ability may also influence activities of daily living (ADLs) after stroke.
Projection hypothesis from the von Neumann-type interaction with a Bose-Einstein condensate
Authors: Konishi Eiji 
Published: October 2021

Abstract
We derive the projection hypothesis in projective quantum measurement by restricting the set of observables. This projection hypothesis accompanies a bipartite system with the von Neumann-type interaction, which consists of a quantum mechanical system, with a meter variable to be measured, and a quantum field theoretically macroscopic extended object, that is, a spatiotemporally inhomogeneous Bose-Einstein condensate in quantum field theory with the quantum coordinate, that is, the zero-energy Goldstone mode(s) of the spontaneously broken global spatial translational symmetry. The key steps in the derivation are the return of the symmetry translation of this quantum coordinate to the inverse translation of the c-number spatial coordinate in quantum field theory and the reduction of quantum fluctuations to classical fluctuations with respect to the Goldstone mode(s) due to a superselection rule.
Variations in Sleep Characteristics and Glucose Regulation in Young Adults With Type 1 Diabetes
Authors: Griggs Stephanie , Grey Margaret , Strohl Kingman P , Crawford Sybil L , Margevicius Seunghee , Kashyap Sangeeta R , Li Chiang-Shan R , Rajagopalan Sanjay , Hickman Ronald L 
Published: October 2021

AbstractContextShort sleep duration and sleep disruptions are associated with impaired glucoregulation in type 1 diabetes (T1D). However, the mechanistic pathways between sleep and glucose variability remain unclear.ObjectiveTo determine within- and between-person associations between objective sleep-wake characteristics and glucose variability indices.MethodsMultilevel models were used to analyze concurrent sleep and glucose patterns over 7 days in 42 young adults with T1D in their natural home environment. Young adults with T1D (mean age 22.2 ± 3.0 years, HbA1c 7.2%, 32.6% male) for at least 6 months with no other medical or major psychiatric comorbidity were included. Sleep-wake characteristics were measured via wrist actigraphy and glucose variability indices via a continuous glucose monitor (CGM).ResultsLower sleep efficiency predicted higher glucose variability (less time in range β = 0.011 and more time in hyperglycemia β = −0.011) within-person. A longer wake after sleep onset and more sleep disruptions were associated with higher glucose variability between persons (β = 0.28 and 0.31). Higher glucose variability predicted poorer sleep within-person (delayed bedtime, waketime, mid-sleep time, and lower sleep efficiency), while higher glucose variability was associated with poorer sleep and more sleep disruptions between persons (lower sleep efficiency, longer wake after sleep onset, and a higher sleep fragmentation index).ConclusionClinicians can address the reciprocal nature of the sleep-glucose relationship by optimizing sleep and targeting efforts toward a euglycemic range overnight. Sleep habits are a modifiable personal target in diabetes care.
Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice
Authors: Téblick Arno , De Bruyn Lauren , Van Oudenhove Tim , Vander Perre Sarah , Pauwels Lies , Derde Sarah , Langouche Lies , Van den Berghe Greet 
Published: October 2021

Abstract

Purpose
Sepsis is hallmarked by high plasma cortisol/corticosterone (CORT), low adrenocorticotropic hormone (ACTH), and high pro-opiomelanocortin (POMC). While corticotropin-releasing hormone-(CRH) and arginine-vasopressin (AVP)-driven pituitary POMC expression remains active, POMC processing into ACTH becomes impaired. Low ACTH is accompanied by loss of adrenocortical structure, although steroidogenic enzymes remain expressed. We hypothesized that treatment of sepsis with hydrocortisone (HC) aggravates this phenotype whereas CRH infusion safeguards ACTH-driven adrenocortical structure.

Methods
In a fluid-resuscitated, antibiotics-treated mouse model of prolonged sepsis, we compared the effects of HC and CRH infusion with placebo on plasma ACTH, POMC, and CORT; on markers of hypothalamic CRH and AVP signaling and pituitary POMC processing; and on the adrenocortical structure and markers of steroidogenesis. In adrenal explants, we studied the steroidogenic capacity of POMC.

Results
During sepsis, HC further suppressed plasma ACTH, but not POMC, predominantly by suppressing sepsis-activated CRH/AVP-signaling pathways. In contrast, in CRH-treated sepsis, plasma ACTH was normalized following restoration of pituitary POMC processing. The sepsis-induced rise in markers of adrenocortical steroidogenesis was unaltered by CRH and suppressed partially by HC, which also increased adrenal markers of inflammation. Ex vivo stimulation of adrenal explants with POMC increased CORT as effectively as an equimolar dose of ACTH.

Conclusions
Treatment of sepsis with HC impaired integrity and function of the hypothalamic-pituitary-adrenal axis at the level of the pituitary and the adrenal cortex while CRH restored pituitary POMC processing without affecting the adrenal cortex. Sepsis-induced high-circulating POMC may be responsible for ongoing adrenocortical steroidogenesis despite low ACTH.
Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy
Authors: Angelidi Angeliki M , Belanger Matthew J , Kokkinos Alexander , Koliaki Chrysi C , Mantzoros Christos S 
Published: October 2021

Abstract
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the discovery of several promising drug targets and novel therapeutic strategies to address the global obesity epidemic and its comorbidities. Current pharmacologic options for obesity management are largely limited in number and of modest efficacy/safety profile. Therefore, the need for safe and more efficacious new agents is urgent. Drugs that are currently under investigation modulate targets across a broad range of systems and tissues, including the central nervous system, gastrointestinal hormones, adipose tissue, kidney, liver, and skeletal muscle. Beyond pharmacotherapeutics, other potential antiobesity strategies are being explored, including novel drug delivery systems, vaccines, modulation of the gut microbiome, and gene therapy. The present review summarizes the pathophysiology of energy homeostasis and highlights pathways being explored in the effort to develop novel antiobesity medications and interventions but does not cover devices and bariatric methods. Emerging pharmacologic agents and alternative approaches targeting these pathways and relevant research in both animals and humans are presented in detail. Special emphasis is given to treatment options at the end of the development pipeline and closer to the clinic (ie, compounds that have a higher chance to be added to our therapeutic armamentarium in the near future). Ultimately, advancements in our understanding of the pathophysiology and interindividual variation of obesity may lead to multimodal and personalized approaches to obesity treatment that will result in safe, effective, and sustainable weight loss until the root causes of the problem are identified and addressed.
Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening
Authors: Spead Olivia , Weaver Cory J. , Moreland Trevor , Poulain Fabienne E. 
Published: October 2021

ABSTRACT
Organization of neuronal connections into topographic maps is essential for processing information. Yet, our understanding of topographic mapping has remained limited by our inability to observe maps forming and refining directly in vivo. Here, we used Cre-mediated recombination of a new colorswitch reporter in zebrafish to generate the first transgenic model allowing the dynamic analysis of retinotectal mapping in vivo. We found that the antero-posterior retinotopic map forms early but remains dynamic, with nasal and temporal retinal axons expanding their projection domains over time. Nasal projections initially arborize in the anterior tectum but progressively refine their projection domain to the posterior tectum, leading to the sharpening of the retinotopic map along the antero-posterior axis. Finally, using a CRISPR-mediated mutagenesis approach, we demonstrate that the refinement of nasal retinal projections requires the adhesion molecule Contactin 2. Altogether, our study provides the first analysis of a topographic map maturing in real time in a live animal and opens new strategies for dissecting the molecular mechanisms underlying precise topographic mapping in vertebrates.
Singing and music making: physiological responses across early to later stages of dementia
Authors: Walker Nina , Crutch Sebastian J. , West Julian , Jones Fergal W. , Brotherhood Emilie V. , Harding Emma , Camic Paul M. 
Published: October 2021

Background: Music based interventions have been found to improve the wellbeing of people living with dementia. More recently there has been interest in physiological measures to provide additional information about how music and singing impact this population. Methods: This multiple-case study design explored physiological responses (heart rate-HR, electrodermal activity-EDA, movement, and skin temperature-ST) of nine people with mild-to-moderate dementia during a singing group, and six people in the later stages of dementia during an interactive music group. The interactive music group was also video recorded to provide information about engagement. Data were analysed using simulation modelling analysis. Results: The singing group showed an increase in EDA (p < 0.01 for 8/9 participants) and HR (p < 0.01 for 5/9 participants) as the session began. HR (p < 0.0001 for 5/9 participants) and ST (p < 0.0001 for 6/9 participants) increased during faster paced songs. EDA (p < 0.01 all), movement (p < 0.01 for 8/9 participants) and engagement were higher during an interactive music group compared to a control session (music listening). EDA (p < 0.0001 for 14/18 participants) and ST (p < 0.001 for 10/18 participants) increased and in contrast to the responses during singing, HR decreased as the sessions began (p < 0.002 for 9/18 participants). EDA was higher during slower music (p < 0.0001 for 13/18 participants), however this was less consistent in more interactive sessions than the control. There were no consistent changes in HR and movement responses during different styles of music. Conclusions: Physiological measures may provide valuable information about the experiences of people with dementia participating in arts and other activities, particularly for those with verbal communication difficulties. Future research should consider using physiological measures with video-analysis and observational measures to explore further how engagement in specific activities, wellbeing and physiology interact.
ИЗУЧЕНИЕ ЭМОЦИОНАЛЬНОЙ СОСТАВЛЯЮЩЕЙ УДОВЛЕТВОРЕННОСТИ СТУДЕНТАМИ ДИСТАНЦИОННЫМИ ОБРАЗОВАТЕЛЬНЫМИ ТЕХНОЛОГИЯМИ
Authors: Matafonova Svetlana I. , Usheva Tatiana F. 
Published: October 2021

В статье представлен обобщённый анализ обратной связи студентов по вопросам реализации дистанционных образовательных технологий.
Предметом представленной работы является отношение студентов к дистанционным образовательным технологиям.
Цель. Данное исследование показывает эмоциональную составляющую удовлетворенности студентами в отношении к обучению с применением дистанционных образовательных технологий.
Методология проведения работы. В основу исследования положен рефлексивный подход, который позволяет анализировать деятельность и проектировать будущий шаг образовательного процесса. В статье анализируются психологические аспекты эмоциональной составляющей удовлетворенности студентами от использования в высшем образовании дистанционных форм обучения. В ходе исследования использовались психолого-педагогические методы. Для анализа ответов анкетирования были использованы как методы контент-анализа, так и методы частотного анализа.
Результаты. Авторами было проведено исследование на кафедре социальной педагогики и психологии на базе ФГБОУ ВО «Иркутский государственный университет» Педагогического института, в 2020-2021 учебном году. Разработана и проведена в формате онлайн анкета на тему «Удовлетворенность дистанционным обучением». Исследование включало в себя пять разделов: релевантность, мотивированность, оценка рефлексивности, оценка качества преподавания и общая оценка удовлетворенности.
Область применения результатов. Представлен анализ данных, определяющий возможность использования в высшем образовании дистанционных образовательных инструментов для организации эффективного учебного процесса.
Study on the Characteristic Components of Distinguishing Dalbergia cochinchinensis from the Other Three Similar Dalbergia Species
Authors: Zhang Fang-Da , Wang Ji-Lei , Guo Li-jin , Huang An-Min , Wang Wenna 
Published: October 2021

Abstract

Dalbergia cochinchinensis can be distinguished from Dalbergia retusa, Dalbergia bariensis, and Dalbergia oliveri quickly using infrared spectrum characteristic peaks as shown in a previous study. To investigate the components corresponding to the infrared characteristic peaks of Dalbergia cochinchinensis, petroleum ether, ethyl acetate, and butyl alcohol were sequentially used to extract the dispersion liquid of D. cochinchinensis. The petroleum ether extracts were further fractionated by column chromatography, using Fourier-transform infrared spectroscopy (FTIR) to track the characteristic components during separation. FTIR spectra of petroleum ether extractives indicated the presence of aromatic ketones and olefin compounds. The gas chromatography–mass spectrometry research showed some main components and gave possible structure. Furthermore, their detailed structures were characterized thorough a nuclear magnetic resonance approach, and then two possible components (3,5-dihydroxy-7-methoxy-2-phenylchroman-4-one and 3,5,7-trihydroxy-2-phenylchroman-4-one) were identified.
Codeswitching auf einem hochdiversen urbanen Wochenmarkt: Kommerz, Kommunikation und Identität
Authors: Yüksel Serkan , Duman İrem 
Published: October 2021

Today's European cities exhibit a great cultural and linguistic diversity. Highly diverse urban areas bring together people from different sociolinguistic backgrounds and thus facilitate intense language contact, with speakers accessing diverse linguistic resources that they creatively use and mix (cf. e. g. Wiese 2020; Otsuji/Pennycook 2010; Pennycook/Otsuji 2015). Such linguistic practices include code-switching.
In previous research on code-switching the focus was on relatively homogeneous settings, mostly bilingual communities (cf. Poplack 2015; Torres Cacoullos/Travis 2015; Bullock/ Toribio 2009). As a part of a larger project, we collected spontaneous speech data through audio and video recordings from a highly diverse street market in Berlin-Neukölln that is popular among locals and tourists, the “Maybachufer-Markt”.
The analysis of our data reveals new insights with respect to sociolinguistic motivations underlying code-switching. In light of commercial intentions, vendors try to switch to a language according to how they construct the customers’ identity (cf. Bucholtz/Hall 2005; Pfaff-Czarnecka 2011). Besides vendors also commodify specific languages or multilingualism (Heller 2010) based on their and others’ language attitudes or they switch to a language for the purpose of maintaining the communication in sales conversations. Correlating these different factors, we will argue that code-switching is used with a commercial motivation in interactions between vendors and customers.
Urbanicity, Health, and Access to Services for People With Intellectual Disability and Developmental Disabilities
Authors: Fortney Stoni , Tassé Marc J. 
Published: October 2021

Abstract
Previous research suggests that residence in non-metropolitan areas is associated with lower access to preventive care and poorer health. However, this research has been largely restricted to the general population, despite data demonstrating disparities in health status and access to healthcare services for people with intellectual and developmental disabilities (IDD). The current study examined several hypotheses involving the effects of rurality on access to preventive healthcare and services and health status: (1) individuals in non-metropolitan areas will have lower preventive healthcare utilization, (2) individuals in non-metropolitan areas will have poorer health outcomes, and (3) individuals in non-metropolitan areas will have poorer access to services. The current study uses data from the National Core Indicators (NCI) Adult Consumer Survey 2015–2016: Final Report which included Rural-Urban Commuting Area (RUCA) Codes for the first time. Results of logistic regression suggest that, despite connection to disability services, the health status and access to preventive healthcare services of people with IDD generally follow patterns similar to those observed in the general population. Namely, people with IDD in non-metropolitan areas have decreased access to healthcare services, preventive healthcare utilization, and health status. Despite some exceptions, it appears effects of rurality are not completely mitigated by current state and federal efforts.
Millimeter-level resolution through-the-wall radar imaging enabled by an optically injected semiconductor laser
Authors: Sun Guanqun , Zhang Fangzheng , Pan Shilong 
Published: October 2021

Millimeter-level resolution through-the-wall radar (TWR) imaging is demonstrated using a broadband nonlinear frequency-modulated (NLFM) signal that is generated by an optically injected semiconductor laser. The proposed system uses period-one dynamics of a semiconductor laser, together with an optical frequency downconversion technique to generate NLFM signals, which addresses the problem of traditional period-one oscillation not being able to generate broadband signals in the low-frequency region. In the experiment, an NLFM signal having a broad bandwidth of 18.5 GHz (1.5–20 GHz) is generated with a corresponding radar range resolution of 8.1 mm. Using this signal, TWR imaging is demonstrated, in which the use of the NLFM signal achieves good side-lobe suppression during pulse compression, and a modified back projection imaging algorithm with sub-aperture weighting is proposed to improve the imaging quality.