bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Right to Liberty
Authors: Lester Eve 
Published: June 2021

Abstract
Often arbitrary, the use of immigration detention as a border control measure may impede not only the right to liberty, but also an individual’s right to seek asylum, arguably a principle of customary international law, and may expose them to the risk of refoulement. As such, alongside the catalogue of human rights issues to which the practice commonly gives rise, immigration detention can jeopardize some of international refugee law’s most fundamental principles. This chapter considers how and why immigration detention has become such an intractable problem, international standards notwithstanding. The chapter focuses on the right to liberty, first situating the use of immigration detention in global and historical context. It then provides an overview of key aspects of the international legal architecture. Recognizing that other socio-political dynamics shape State practice, the chapter then considers the role of criminalizing and securitizing discourses that are used to rationalize (and even normalize) immigration detention. It suggests that these discourses are crucial to contemporary understandings of, and justifications for, the use and extraterritorial procurement of immigration detention as a border control measure. It argues that paying attention to the history and context of immigration detention and how it is rationalized will reveal more about what law is and does and the mischiefs of which it is capable than doctrinal analysis can do alone. Finally, it suggests the Global Compact on Migration to be a useful lens through which future research might usefully tackle the problem of immigration detention.
Association of semi-quantitative cryptococcal antigen results in plasma with subclinical cryptococcal meningitis and mortality among patients with advanced HIV disease
Authors: Blasich Nozuko P , Wake Rachel M , Rukasha Ivy , Prince Yvonne , Govender Nelesh P 
Published: June 2021

Abstract

Blood cryptococcal antigen (CrAg) titers &gt;160 are associated with concurrent subclinical cryptococcal meningitis (CM). When lumbar puncture (LP) is not immediately available in a CrAg screening program, semi-quantitative CrAg assays may provide risk stratification for CM. Two semi-quantitative assays (SQ [Immuno-Mycologics, Norman, OK, USA] and CryptoPS [Biosynex, Strasbourg, France]) were evaluated against a qualitative lateral flow assay (LFA) using 194 plasma samples from a cohort of HIV-seropositive individuals with CD4 counts &lt;100 cells/μl. We compared SQ and CryptoPS results to titers for LFA-positive samples. Among patients with LP, we examined the association between semi-quantitative CrAg results and CM. We used a Cox proportional hazards model to determine the association between SQ score and mortality. Of 194 participants, 60 (31%) had positive LFA results, of whom 41 (68%) had a titer of ≤160 and 19 (32%) a titer &gt;160. Fifty individuals with antigenemia had an LP; a clinically useful SQ score that identified all ten cases of subclinical CM was ≥3 (100% sensitivity, 55% specificity). Patients with an SQ score of 3 or 4 also had a 2.2-fold increased adjusted hazards of 6-month mortality (95% CI: 0.79–6.34; p = 0.13) versus those with score of &lt;3. Nine of ten patients with subclinical CM had a strong-positive CryptoPS result versus 10/40 without subclinical CM (p &lt; 0.001). Semi-quantitative assays offered a sensitive though not specific means of gauging the risk of concurrent CM in this patient population.

Lay summary
We evaluated two single-step laboratory tests that can quantify the amount of cryptococcal antigen in plasma of patients with advanced HIV disease and could thus gauge the risk of concurrent cryptococcal meningitis and subsequent mortality. These tests are not a substitute for a lumbar puncture.
In situ measurements and neural network analysis of the profiles of optical turbulence over the Tibetan Plateau
Authors: Su Changdong , Wu Xiaoqing , Wu Su , Yang Qike , Han Yajuan , Qing Chun , Luo Tao , Liu Yi 
Published: June 2021

ABSTRACT
The vertical profile of $C_n^2$ is the main factor for accurate astronomical observation and laser communication, however, hardware-based instruments and associated data are not widely available due to logistical and financial issues. In this article, we developed an indirect method, a hybrid network structure which is a combination of the backpropagation neural network and the simulated annealing algorithm, to fit the vertical profile of $C_n^2$. Radiosonde measurements from a field campaign over the Tibetan Plateau at Dachaidan (37.7○N, 95.3○E, 3180 m ASL) were performed in 2020 August to estimate the accuracy of our model, during which a balloon-borne portable turbulence meteorological radiosonde was used to measure the atmospheric optical profiles. Besides, the integrated astronomical parameters (the coherence length r0, seeing ε0, isoplanatic angle θ0, and the wavefront coherence time τ0), derived from $C_n^2$ and wind-speed vertical profiles, are investigated for astronomical applications using the proposed model. In addition, quantitative evaluations such as the correlation coefficient, the root mean squared error, and the systematic bias are used to quantify the performance of our model. More interesting, this model is found to outperform a widely used external scale model for the prevalent atmospheric conditions and shows better correlation and reliable estimates.
A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
Authors: Halatsch Marc-Eric , Kast Richard E , Karpel-Massler Georg , Mayer Benjamin , Zolk Oliver , Schmitz Bernd , Scheuerle Angelika , Maier Ludwig , Bullinger Lars , Mayer-Steinacker Regine , Schmidt Carl , Zeiler Katharina , Elshaer Ziad , Panther Patricia , Schmelzle Birgit , Hallmen Anke , Dwucet Annika , Siegelin Markus D , Westhoff Mike-Andrew , Beckers Kristine , Bouche Gauthier , Heiland Tim 
Published: June 2021

AbstractBackgroundThe dismal prognosis of glioblastoma (GBM) may be related to the ability of GBM cells to develop mechanisms of treatment resistance. We designed a protocol called Coordinated Undermining of Survival Paths combining 9 repurposed non-oncological drugs with metronomic temozolomide—version 3—(CUSP9v3) to address this issue. The aim of this phase Ib/IIa trial was to assess the safety of CUSP9v3.MethodsTen adults with histologically confirmed GBM and recurrent or progressive disease were included. Treatment consisted of aprepitant, auranofin, celecoxib, captopril, disulfiram, itraconazole, minocycline, ritonavir, and sertraline added to metronomic low-dose temozolomide. Treatment was continued until toxicity or progression. Primary endpoint was dose-limiting toxicity defined as either any unmanageable grade 3–4 toxicity or inability to receive at least 7 of the 10 drugs at ≥ 50% of the per-protocol doses at the end of the second treatment cycle.ResultsOne patient was not evaluable for the primary endpoint (safety). All 9 evaluable patients met the primary endpoint. Ritonavir, temozolomide, captopril, and itraconazole were the drugs most frequently requiring dose modification or pausing. The most common adverse events were nausea, headache, fatigue, diarrhea, and ataxia. Progression-free survival at 12 months was 50%.ConclusionsCUSP9v3 can be safely administered in patients with recurrent GBM under careful monitoring. A randomized phase II trial is in preparation to assess the efficacy of the CUSP9v3 regimen in GBM.
Impact of postoperative dexamethasone on survival, steroid dependency, and infections in newly diagnosed glioblastoma patients
Authors: Mistry Akshitkumar M , Jonathan Sumeeth V , Monsour Meredith A , Mobley Bret C , Clark Stephen W , Moots Paul L 
Published: June 2021

AbstractBackgroundWe examined the effect of dexamethasone prescribed in the initial 3 postoperative weeks on survival, steroid dependency, and infection in glioblastoma patients.MethodsIn this single-center retrospective cohort analysis, we electronically retrieved inpatient administration and outpatient prescriptions of dexamethasone and laboratory values from the medical record of 360 glioblastoma patients. We correlated total dexamethasone prescribed from postoperative day (POD) 0 to 21 with survival, dexamethasone prescription from POD30 to POD90, and diagnosis of an infection by POD90. These analyses were adjusted for age, Karnofsky performance status score, tumor volume, extent of resection, IDH1/2 tumor mutation, tumor MGMT promoter methylation, temozolomide and radiotherapy initiation, and maximum blood glucose level.ResultsPatients were prescribed a median of 159 mg [109-190] of dexamethasone cumulatively by POD21. Every 16-mg increment (4 mg every 6 hours/day) of total dexamethasone associated with a 4% increase in mortality (95% confidence interval [CI] 1%-7%, P &lt; .01), 12% increase in the odds of being prescribed dexamethasone from POD30 to POD90 (95% CI 6%-19%, P &lt; .01), and 10% increase in the odds of being diagnosed with an infection (95% CI, 4%-17%, P &lt; .01). Of the 175 patients who had their absolute lymphocyte count measured in the preoperative week, 80 (45.7%) had a value indicative of lymphopenia. In the POD1-POD28 period, this proportion was 82/167 (49.1%).ConclusionsLower survival, steroid dependency, and higher infection rate in glioblastoma patients associated with higher dexamethasone administration in the initial 3 postoperative weeks. Nearly half of the glioblastoma patients are lymphopenic preoperatively and up to 1 month postoperatively.
Understanding human influence on climate change in China
Authors: Sun Ying , Zhang Xuebin , Ding Yihui , Chen Deliang , Qin Dahe , Zhai Panmao 
Published: June 2021

Abstract
China's climate has been warming since the 1950s, with surface air temperature increasing at a rate higher than the global average. Changes in climate have exerted substantial impacts on water resources, agriculture, ecosystems and human health. Attributing past changes to causes provides a scientific foundation for national and international climate policies. Here, we review recent progress in attributing the observed climate changes over past decades in China. Anthropogenic forcings, dominated by greenhouse gas emissions, are the main drivers for observed increases in mean and extreme temperatures. Evidence of the effect of anthropogenic forcings on precipitation is emerging. Human influence has increased the probability of extreme heat events, and has likely changed the occurrence probabilities for some heavy precipitation events. The way a specific attribution question is posed and the conditions under which the question is addressed present persistent challenges for appropriately communicating attribution results to non-specialists.
Smoking Cessation and Preterm Birth in Second Pregnancy Among Women who Smoked in Their First
Authors: Pereira Gavin , Dunne Jennifer , Regan Annette K , Tessema Gizachew A 
Published: June 2021

Abstract

Introduction
The benefit of smoking cessation in reducing the risk of preterm birth is well established. Relatively less well understood is the prevalence of smoking cessation maintenance at the next pregnancy and the associated preterm risk reduction. The aim of this study was to estimate the prevalence of maintenance of smoking cessation at second pregnancy and the associated relative risk of preterm birth.

Methods
This was a longitudinal study with retrospectively obtained records of births to multiparous women who smoked in the pregnancy of their first birth in New South Wales, 1994–2016 (N = 63 195 mothers). Relative risks (RR) of preterm birth of the second child were estimated for smoking cessation with adjustment for final gestational age of the first birth, maternal age at the first birth, change in socioeconomic disadvantage between the first and second pregnancy, interpregnancy interval, and calendar time.

Results
Approximately 34% (N = 21 540) of women who smoked during their first pregnancy did not smoke in the second pregnancy. Smoking cessation among women who smoked at first pregnancy was associated with a 26% (95% CI: 21%, 31%) decrease in risk of preterm birth at a second pregnancy.

Conclusion
Despite smoking during the first pregnancy, smoking cessation was achieved and maintained by more than one-third of women in their second pregnancy with encouraging levels of preterm risk reduction. It is well-established that the period after birth provides an opportunity to reduce smoking-related morbidity for both the mother and neonate. Our results indicate that this period also offers an opportunity to prevent morbidity of future pregnancy.

Implications
A considerable amount of research has been undertaken on the effects of smoking during pregnancy on birth outcomes, the influence of postpartum smoking on the health of the mother and newborn child, and postpartum smoking cessation. However, follow-up of women after giving birth does not tend to be long enough to observe smoking and outcomes of subsequent pregnancies. We show that smoking cessation in the subsequent pregnancy is achievable by a large proportion of women despite smoking in their first pregnancy, which translates to clear reductions in risk of preterm birth in the subsequent pregnancy.
Acute Immune Thrombocytopenia (ITP) Following COVID-19 Vaccination in a Patient With Previously Stable ITP
Authors: Jawed Muzamil , Khalid Amna , Rubin Mayer , Shafiq Ramsha , Cemalovic Nail 
Published: June 2021

Abstract
Immune thrombocytopenia (ITP) is an autoimmune condition associated with multiple risk factors including viral infections (hepatitis B virus/hepatitis C virus/cytomegalovirus, HIV, and recently severe acute respiratory syndrome coronavirus 2) and vaccines. Though immune mechanisms have been proposed to explain the pathogenesis of acute ITP, autoimmunity with the coronavirus disease 2019 (COVID-19) vaccine is still unclear and needs further research. We report a case of acute ITP after administration of the Pfizer-BioNTech mRNA COVID-19 vaccine in a patient with previously stable ITP.
Cavernous Sinus Meningioma: Tumor Decompression for Trigeminal Neuralgia and Anterior Tibial Artery Graft High-Flow Bypass for Brain Ischemia: 2-Dimensional Operative Video
Authors: Qazi Zeeshan , Balasubramanian Sneha Chitra , Abecassis Josh , Hernandez Juan P Carrasco , Shenoy Varadaraya S , Sekhar Laligam N 
Published: June 2021

Abstract
A 62-yr-old man with left cavernous sinus tumor presented with atypical trigeminal neuralgia refractory to medical treatment. He received Gamma Knife (Elekta) radiation for the tumor. However, the facial pain worsened after radiation. Neuropsychological testing done for memory problems had revealed mild neurocognitive disorder. Neurological examination showed trigeminal distribution numbness and partial abducens nerve paralysis. Imaging revealed an enhancing left cavernous sinus and supra-cavernous mass. Angiography revealed severe stenosis of the left cavernous internal carotid artery (ICA). Computed tomography (CT) perfusion study showed diminished blood flow on the left side, and ischemic changes were seen in fluid-attenuated inversion-recovery (FLAIR) magnetic resonance imaging (MRI).
Surgical resection of the tumor was preferred over ablative treatment for trigeminal neuralgia because of its effectiveness in improving cranial nerve (CN) function.
1
The patient underwent staged surgeries. In the first stage, the tumor was partially excised with decompression of the trigeminal ganglion and nerve root in the lateral cavernous sinus wall, Meckel's cave. Postoperatively, MR angiography revealed worsening of the left ICA caliber. Therefore, a high-flow bypass from the external carotid artery to the middle cerebral artery (MCA) was performed with an anterior tibial artery graft. The patient recovered initially but developed enterococcus meningitis postoperatively, which was promptly identified and treated with antibiotics. At 1-yr follow-up, the graft was patent, and the patient had significant relief of his facial pain and cognitively improved.
This 2-dimensional video demonstrates the technique of partial excision of cavernous sinus meningioma with CN decompression, and the technique of a high-flow bypass from the external carotid artery to M2 MCA segment using an anterior tibial artery graft.
The patient gave informed consent for surgery and video recording. All relevant patient identifiers have been removed from the video and accompanying radiology slides.
Lateral Suboccipital Craniotomy With C1-C2 Hemilaminectomies and C1-C3 Fusion for the Treatment of a C1-C2 Synovial Cyst Causing Spinal Cord Compression: 2-Dimensional Operative Video
Authors: Croci Davide Marco , Fredrickson Vance L , Hollon Todd C , Dailey Andrew T , Couldwell William T 
Published: June 2021

Abstract
Atlantoaxial synovial cysts are a rare cause of cervical myelopathy. Here we describe a case of a 26-yr-old woman who presented with progressively decreasing right arm and leg strength and associated gait imbalance. On examination, she had diffuse weakness in the right upper and lower extremities, a positive right-sided Hoffman sign, and clonus in the right lower extremity. Computed tomography demonstrated an os odontoideum and a retro-odontoid cyst. Magnetic resonance imaging demonstrated a T1 hypointense, T2 hyperintense, slightly rim-enhancing retro-odontoid cyst causing a marked narrowing of the spinal canal, with resultant flattening and leftward deviation of the spinal cord. The patient consented to undergo cyst fenestration via a right suboccipital craniotomy and right C1-C2 hemilaminectomies, along with a C1-C3 instrumented posterior spinal fusion. This approach was chosen because it allows for cyst fenestration and instrumentation of the hypermobile cervical spine within the same incision. After the dura was opened and the arachnoid was dissected, the cyst was visualized compressing the spinal cord. The cyst was fenestrated just inferior to the C1 nerve rootlets, resulting in immediate egress of a gelatinous content; thereafter, all accessible cyst wall portions were removed. Fusion was performed with lateral mass screws at C1 and C3 and pars screws at C2. Pathological analysis described the cyst content as reactive fibrovascular tissue with cholesterol deposition. There were no complications associated with the procedure, and the patient's right-sided weakness had nearly resolved by postoperative day 1. Patient consent was granted for publication.
The Effect of Reducing Intravenous Push Opioid Use on Hospital Medicine Patients’ Pain Experience During Hospitalization
Authors: Smith G Randy , Ramalingam Sridevi , Zhou Shuhan , Yeh Chen , Lee Jungwha , O’Leary Kevin J 
Published: June 2021

Abstract

Objective
To determine the efficacy of a program to limit the use of the intravenous (IV) push route for opioids on the experience of pain by inpatients and on associated safety events.

Design
Retrospective cohort study.

Setting
Two inpatient general medicine floor units at an urban tertiary care academic medical center.

Subjects
4,752 inpatient opioid recipients.

Methods
Patients in one unit were exposed to a multidisciplinary intervention to limit the prescription of opioids via the IV push route, with the other unit used as a control unit. The primary study outcome was the mean numeric pain score per patient during the hospital stay. Secondary measures included the hospital length of stay and postdischarge patient satisfaction. Fidelity measures included the percentage of the patient population exposed to each opioid administration route and the amount of opioid administered per route. Safety measures included patient disposition, transfer to intensive care, and incidence of naloxone administration.

Results
The intervention was successful in decreasing both the percentage of patients exposed to IV push opioids and the amount of opioid administered via the IV push route, but no associated changes in other study outcomes were identified.

Conclusions
For the treatment of acute pain in medical inpatients, no evidence of benefit or harm was identified in relation to an increase or decrease in the use of the IV push opioid route.
Moving on Up? Neighborhood Status and Racism-Related Distress among Black Americans
Authors: DeAngelis Reed T 
Published: June 2021

AbstractAt all levels of socioeconomic status, Black Americans can expect to live shorter and sicker lives than their White counterparts. This study advances the perspective that anti-Black stigma from Whites precludes Blacks from reaping the full health rewards of higher status, particularly within the context of neighborhoods. To test this hypothesis, I merge census data with rich survey and biomarker data from the Nashville Stress and Health Study, a representative sample of Black and White adults from Davidson County, Tennessee (n = 1,252). Initially, I find that Blacks who reside in higher status and mostly White communities exhibit lower levels of neuroendocrine stress hormones, relative to their peers living in disadvantaged Black neighborhoods. But Blacks in higher-status areas also report more perceived discrimination. In turn, perceived discrimination is associated with chronic bodily pain, as well as elevated stress hormones and blood pressure tied to high goal-striving stress, or fears of being blocked from reaching life goals. After accounting for racism-related stressors, Blacks exhibit comparable levels of physiological distress regardless of neighborhood context. The inverse is true for Whites, who report fewer stressors in higher-status neighborhoods, and less physiological distress than Blacks overall. Findings are discussed within the context of social evolutionary theories of the human brain and are dovetailed with broader racial health disparities in the United States.
Polio Vaccine Struggles: FAIR and the Failed Reintroduction of Inactivated Polio Vaccine, 1975–1985
Authors: Baylac-Paouly Baptiste , Hendriks Jan , Blume Stuart 
Published: June 2021

Summary
This article discusses the strategies and trajectories deployed by the Forum for the Advancement of Immunization Research (FAIR) to rehabilitate Salk’s inactivated polio vaccine (IPV), at a time when Sabin’s oral polio vaccine (OPV) had come to dominate the global polio vaccine market. FAIR was an international coalition of scientists and institutions that undertook specific field studies to establish the conditions under which IPV could usefully be introduced in developing countries. Regardless of the evidence it gathered, FAIR failed to convince WHO to integrate IPV into the Expanded Programme on Immunization (EPI). This study of the life of IPV vaccine beyond its initial development and introduction, provides insights in the interplay of evidence and interests in the political decisions made around vaccination.
Building Biofoundry India: challenges and path forward
Authors: Panda Binay , Dhar Pawan K 
Published: June 2021

Abstract
Biofoundry is a place where biomanufacturing meets automation. The highly modular structure of a biofoundry helps accelerate the design–build–test–learn workflow to deliver products fast and in a streamlined fashion. In this perspective, we describe our efforts to build Biofoundry India, where we see the facility add a substantial value in supporting research, innovation and entrepreneurship. We describe three key areas of our focus, harnessing the potential of non-expressing parts of the sequenced genomes, using deep learning in pathway reconstruction and synthesising enzymes and metabolites. Toward the end, we describe specific challenges in building such facility in India and the path to mitigate some of those working with the other biofoundries worldwide.