bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do stock markets play a role in determining COVID‐19 economic stimulus? A cross‐country analysis
Authors: Shafiullah Muhammad , Khalid Usman , Chaudhry Sajid M. 
Published: April 2021

AbstractThis paper makes an innovative contribution to the extant literature by analysing the determinants of economic stimulus packages implemented by governments in response to the COVID‐19 pandemic. In particular, we explore whether stock market declines observed in many countries can predict the size of COVID‐19 stimulus packages. Moreover, we explore whether a country's level of income can augment the underlying relationship between stock market declines and stimulus packages. The findings reveal that a larger stock market decline results in a larger stimulus package; however, this effect is only observed in countries that have an income level greater than the mean and/or median per capita gross domestic product (GDP). Moreover, our results show that monetary policy is more responsive to a stock market decline than fiscal policy. Thus, our results underscore the importance of international donor agencies such as the World Bank and International Monetary Fund (IMF) in supporting less affluent countries in coping with the adverse impacts of the COVID‐19 pandemic on their economies.
Mechanical Properties of Additively Manufactured Periodic Cellular Structures and Design Variations
Authors: Spear Derek G. , Palazotto Anthony N. , Kemnitz Ryan A. 
Published: April 2021

Abstract
Advances in manufacturing technologies have led to the development of a new approach to material selection, in which architectured designs can be created to achieve a specific mechanical objective. Cellular lattice structures have been at the forefront of this movement due to the ability to tailor their mechanical response through tuning of the topology, surface thickness, cell size, and cell density. In this work, the mechanical properties of additively manufactured periodic cellular lattices are evaluated and compared, primarily through the topology and surface thickness parameters. The evaluated lattices were based upon triply periodic minimal surfaces (TPMS), including novel variations on the base TPMS designs, which have not been tested previously. These lattices were fabricated out of Inconel 718 (IN718) through the selective laser melting (SLM) process. Specimens were tested under uniaxial compression, and the resultant mechanical properties were determined. Further discussion of the fabrication quality and deformation behavior of the lattices is provided. Results of this work indicate that the Diamond TPMS lattice has superior mechanical properties to the other lattices tested. Additionally, with the exception of the primitive TPMS lattice, the base TPMS designs exhibited superior mechanical performance to their derivative lattice designs.
Computation of Hydrodynamic and Capillary Phenomena in Binder Jet Three-Dimensional Printing
Authors: Wagner Joshua J. , Fred Higgs C. 
Published: April 2021

Abstract
The fundamental operation in binder jet three-dimensional printing is the deposition of liquid binder into a powder layer to selectively bond particles together. Upon droplet impact, the binder spreads into the powder bed forming a bound network of wetted particles called a primitive. A computational fluid dynamics framework is proposed to directly simulate the capillary and hydrodynamic effects of the interfacial flow that is responsible for primitive formation. The computational model uses the volume-of-fluid method for capturing dynamic binder-air interfaces, and the immersed boundary method is adopted to include particle geometries on numerical Cartesian grids. Three-phase contact angles are prescribed through an interface extension algorithm. Binder droplet impact on powder beds of varying contact angle are simulated. Furthermore, the numerical model is used to simulate liquid bridges connecting binary and ternary particle systems, and the resulting capillary and hydrodynamic forces are validated by comparison with published experimental and theoretical model results.
Obesity and Natural Spaces in Adults and Older People: A Systematic Review
Authors: Teixeira Andreia , Gabriel Ronaldo , Quaresma Luis , Alencoão Ana , Martinho José , Moreira Helena 
Published: April 2021

Background: Obesity is an important public health issue that has increased globally in the last decade and continues to be one of the main causes of morbidity and premature mortality. An accumulating body of evidence suggests that contact with nature is a valuable resource for the promotion of a more active lifestyle and seems to have a central role in maintaining a healthy weight. The authors conducted a systematic review to summarize the findings of studies that investigated the relationship between natural spaces and obesity. Methods: Following Primary Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a literature search was conducted using 11 databases for studies fully available in English and published between 2010 and 2020, with adults (18–64 y) and/or older people (≥65 y). Results: Fifty studies were found that met all the inclusion criteria. The majority (68%) of papers found that higher availability and less distance to green and blue spaces are associated with lower levels of adiposity. These associations were positive, even after adjusting for the demographic and socioeconomic factors. Conclusions: Exploring the characteristics of green and blue spaces seems to be a promising tool for urban planning and health policies. The authors suggest the implementation of exercise programs in contact with nature for future interventions.
Subduction initiation of the western Proto-Tethys Ocean: New evidence from the Cambrian intra-oceanic forearc ophiolitic mélange in the western Kunlun Orogen, NW Tibetan Plateau
Authors: Zhang Qichao , Li Zhong-Hai , Wu Zhenhan , Chen Xuanhua , Zhang Ji'en , Yang Yan 
Published: April 2021

Abstract
The supra-subduction zone ophiolite or ophiolitic mélange formed in the forearc setting is generally considered to be a key geological record for subduction initiation (SI) with petrological characteristics comparable to the SI-related rock sequence from forearc basalt (FAB) to boninite in the Izu-Bonin-Mariana subduction zone. Nevertheless, the standard FAB and boninite are generally difficult to observe in the forearc rocks generated during SI. Yet, a typical rock sequence indicating the SI of the western Proto-Tethys Ocean is reported for the first time in the Qimanyute intra-oceanic forearc system in the western Kunlun Orogen, Northwest Tibetan Plateau. The magmatic compositions, which range from less to more high field strength element (HFSE)-depleted and large ion lithophile element (LILE)-enriched, are changing from oceanic plagiogranites (ca. 494 Ma) to forearc basalt-like gabbros (FAB-Gs, ca. 487 Ma), boninites, and subsequent Nb-enriched gabbros (NEGs, ca. 485 Ma), which are thus consistent with the Izu-Bonin-Mariana forearc rocks as well as the Troodos and Semail supra-subduction zone-type ophiolites. The geochemical data from the chemostratigraphic succession indicate a subduction initiation process from a depleted mid-oceanic-ridge (MORB)-type mantle source with no detectable subduction input to gradual increasing involvement of subduction-derived materials (fluid/melts and sediments). The new petrological, geochemical, and geochronological data, combined with the regional geology, indicate that the well-sustained FAB-like intrusive magmas with associated boninites could provide crucial evidence for SI and further reveal that the SI of the western Proto-Tethys Ocean occurred in the Late Cambrian (494–485 Ma).
Associations between continuous glucose monitoring-derived metrics and diabetic retinopathy and albuminuria in patients with type 2 diabetes
Authors: Wakasugi Satomi , Mita Tomoya , Katakami Naoto , Okada Yosuke , Yoshii Hidenori , Osonoi Takeshi , Nishida Keiko , Shiraiwa Toshihiko , Torimoto Keiichi , Kurozumi Akira , Gosho Masahiko , Shimomura Iichiro , Watada Hirotaka 
Published: April 2021

IntroductionPreventing the development and progression of diabetic microvascular complications through optimal blood glucose control remains an important challenge. Whether metrics based on continuous glucose monitoring are useful for the management of diabetic microvascular complications is not entirely clear.Research design and methodsThis is an exploratory analysis of an ongoing prospective, multicenter, 5-year follow-up observational study. Study participants included 999 outpatients with type 2 diabetes who underwent continuous glucose monitoring at baseline. Associations between continuous glucose monitoring-derived metrics and the severity of diabetic retinopathy or albuminuria were investigated using multivariable proportional odds models.ResultsThe overall prevalence of diabetic retinopathy was 22.2%. Multivariate analysis with proportional odds models demonstrated that continuous glucose monitoring-derived metrics related to intraday and interday glucose variability are significantly associated with the severity of diabetic retinopathy, even after adjusting for various possible risk factors. However, significant relationships were not observed after adjusting for hemoglobin A1c (HbA1c) levels. The prevalence of microalbuminuria and macroalbuminuria was 20.3% and 6.7%, respectively. Similarly, multivariate analysis demonstrated that those metrics are significantly associated with the severity of albuminuria. These relationships remained significant even after further adjusting for HbA1c levels.ConclusionsContinuous glucose monitoring-derived metrics related to intraday and interday glucose variability are significantly associated with the severity of diabetic retinopathy or albuminuria in patients with type 2 diabetes. Thus, evaluating these metrics might possibly be useful for risk assessment of diabetic microvascular complications.Trial registration numberUMIN000032325.
Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study
Authors: Takeda Kohei , Mizutani Koji , Minami Isao , Kido Daisuke , Mikami Risako , Konuma Kuniha , Saito Natsumi , Kominato Hiromi , Takemura Shu , Nakagawa Keita , Izumi Yuichi , Ogawa Yoshihiro , Iwata Takanori 
Published: April 2021

IntroductionThe aim was to investigate the relationship of full-mouth inflammatory parameters of periodontal disease with diabetes and obesity.Research design and methodsThis cross-sectional study conducted diabetes-related examinations and calculated periodontal inflamed and epithelial surface area (PISA and PESA) of 71 Japanese patients with type 2 diabetes. Multiple linear regression analyses were performed to evaluate associations between PISA or PESA and diabetes and obesity parameters.ResultsMedian value of body mass index (BMI), hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, and visceral fat area (VFA) were 25.7 kg/m2, 9.1%, 151 mg/L, and 93.3 cm2, respectively. PISA and PESA were significantly associated with HbA1c after adjusting for age, sex, BMI, smoking status, and full-mouth plaque control level (PISA: coefficient=38.1, 95% CI 8.85 to 67.29, p=0.001; PESA: coefficient=66.89, 95% CI 21.44 to 112.34, p=0.005). PISA was also significantly associated with the highest FPG tertile (>175 mg/dL) after adjusting for confounders (coefficient=167.0, 95% CI 48.60 to 285.4, p=0.006). PISA and PESA were not significantly associated with BMI or VFA.ConclusionPISA was associated with FPG and HbA1c, but not with obesity parameters, independent from confounders such as full-mouth plaque control level in patients with type 2 diabetes.
Disrespect and abuse as a predictor of postnatal care utilisation and maternal-newborn well-being: a mixed-methods systematic review
Authors: Minckas Nicole , Gram Lu , Smith Colette , Mannell Jenevieve 
Published: April 2021

IntroductionGlobally, a substantial number of women experience abusive and disrespectful care from health providers during childbirth. As evidence mounts on the nature and frequency of disrespect and abuse (D&A), little is known about the consequences of a negative experience of care on health and well-being of women and newborns. This review summarises available evidence on the associations of D&A of mother and newborns during childbirth and the immediate postnatal period (understood as the first 24 hours from birth) with maternal and neonatal postnatal care (PNC) utilisation, newborn feeding practices, newborn weight gain and maternal mental health.MethodsWe conducted a systematic review of all published qualitative, quantitative and mixed-methods studies on D&A and its postnatal consequences across all countries. Pubmed, Embase, Web of Science, LILACS and Scopus were searched using predetermined search terms. Quantitative and qualitative data were analysed and presented separately. Thematic analysis was used to synthesise the qualitative evidence.ResultsA total of 4 quantitative, 1 mixed-methods and 16 qualitative studies were included. Quantitative studies suggested associations between several domains of D&A and use of PNC as well as maternal mental health. Different definitions of exposure meant formal meta-analysis was not possible. Three main themes emerged from the qualitative findings associated with PNC utilisation: (1) women’s direct experiences; (2) women’s expectations and (3) women’s agency.ConclusionThis review is the first to examine the postnatal effect of D&A of women and newborns during childbirth. We highlight gaps in research that could help improve health outcomes and protect women and newborns during childbirth. Understanding the health and access consequences of a negative birth experience can help progress the respectful care agenda.
Twelve-year persistence of inequalities in antenatal care utilisation among women in Tanzania: a decomposition analysis of population-based cross-sectional surveys
Authors: Bintabara Deogratius , Basinda Namanya 
Published: April 2021

ObjectiveThis study was undertaken to assess the trend and contributors of socioeconomic inequalities in antenatal care (ANC) utilisation among women of reproductive age in Tanzania from 2004 to 2016.DesignPopulation-based cross-sectional surveys.SettingThis study analysed nationally representative data for women of reproductive age obtained from the 2004–2016 Tanzania Demographic Health Surveys.Primary outcome measureThe outcome variables analysed in this study are: (1) attendance of ANC and (2) accessing adequate antenatal care.Analytical methodsThe concentration curve and the concentration index were used to measure socioeconomic inequality in attending and accessing adequate ANC. The concentration index was decomposed to identify the factors explaining the observed socioeconomic inequality of these two outcomes.ResultsThe concentration index for attending at least four ANC visits increased from 0.169 in 2004 to 0.243 in 2016 (p<0.01). Similarly, for accessing adequate care, the index increased from 0.147 in 2004 to 0.355 in 2016 (p<0.01). This indicates the significant increase in socioeconomic inequalities (favouring wealthier women) for these two outcomes over time. Furthermore, the results show that wealth status was the largest contributor to inequality in both attending at least four visits (71%, 50% and 70%) and accessing adequate ANC (50%, 42% and 51%) in 2004, 2010 and 2016, respectively, in favour of wealthier women (p<0.05). The other contributors to socioeconomic inequalities in ANC utilisation were maternal education and type of residence.ConclusionOver the 12 years of surveys, there was no reduction in socioeconomic inequalities in ANC utilisation in Tanzania. Therefore, the efforts of achieving universal health coverage should focus on reducing wealth-related inequality and improving women’s education from poor households.
Frailty degree and illness trajectories in older people towards the end-of-life: a prospective observational study
Authors: Amblàs-Novellas Jordi , Murray Scott A , Oller Ramon , Torné Anna , Martori Joan Carles , Moine Sébastien , Latorre-Vallbona Nadina , Espaulella Joan , Santaeugènia Sebastià J , Gómez-Batiste Xavier 
Published: April 2021

ObjectivesTo assess the degree of frailty in older people with different advanced diseases and its relationship with end-of-life illness trajectories and survival.MethodsProspective, observational study, including all patients admitted to the Acute Geriatric Unit of the University Hospital of Vic (Spain) during 12 consecutive months (2014–2015), followed for up to 2 years. Participants were identified as end-of-life people (EOLp) using the NECPAL (NECesidades PALiativas, palliative care needs) tool and were classified according to their dominant illness trajectory. The Frail-VIG index (Valoración Integral Geriátrica, Comprehensive Geriatric Assessment) was used to quantify frailty degree, to calculate the relationship between frailty and mortality (Receiver Operating Characteristic (ROC) curves), and to assess the combined effect of frailty degree and illness trajectories on survival (Cox proportional hazards model). Survival curves were plotted using the Kaplan-Meier estimator with participants classified into four groups (ie, no frailty, mild frailty, moderate frailty and advanced frailty) and were compared using the log-rank test.ResultsOf the 590 persons with a mean (SD) age of 86.4 (5.6) years recruited, 260 (44.1%) were identified as EOLp, distributed into cancer (n=31, 11.9%), organ failure (n=79, 30.4%), dementia (n=86, 33.1%) and multimorbidity (n=64, 24.6%) trajectories. All 260 EOLp had some degree of frailty, mostly advanced frailty (n=184, 70.8%), regardless of the illness trajectory, and 220 (84.6%) died within 2 years. The area under the ROC curve (95% CI) after 2 years of follow-up for EOLp was 0.87 (0.84 to 0.92) with different patterns of survival decline in the different end-of-life trajectories (p<0.0001). Cox regression analyses showed that each additional deficit of the Frail-VIG index increased the risk of death by 61.5%, 30.1%, 29.6% and 12.9% in people with dementia, organ failure, multimorbidity and cancer, respectively (p<0.01 for all the coefficients).ConclusionsAll older people towards the end-of-life in this study were frail, mostly with advanced frailty. The degree of frailty is related to survival across the different illness trajectories despite the differing survival patterns among trajectories. Frailty indexes may be useful to assess end-of-life older people, regardless of their trajectory.
Excess costs of type 2 diabetes and their sociodemographic and clinical determinants: a cross-sectional study using data from the German Health Interview and Examination Survey for Adults (DEGS1)
Authors: König Hannah , Rommel A , Baumert Jens , Schmidt Christian , König Hans-Helmut , Brettschneider Christian , Konnopka Alexander 
Published: April 2021

ObjectivesThe objectives of this study were to estimate the direct and indirect excess costs of type 2 diabetes mellitus (T2D) using data representative for the German adult population and to investigate the association of sociodemographic and clinical determinants with these excess costs.SettingWe calculated mean annual costs for individuals with T2D and a control group without diabetes, using data on healthcare utilisation and productivity losses from the cross-sectional German Health Interview and Examination Survey for Adults. We adjusted for group differences using entropy balancing and estimated excess costs for total, direct, indirect costs and additional cost categories using generalised linear models. We performed subgroup analyses to investigate the association of sociodemographic (age, sex and education) and clinical determinants (diabetes duration, glycaemic index and complications) with excess costs.ParticipantsThe final study sample included n=325 individuals with T2D and n=4490 individuals without diabetes in the age between 18 and 79 years.ResultsTotal excess costs amounted to €927, of which €719 were attributable to direct and €209 to indirect excess costs. Total costs were significantly increased by 28% for T2D compared with controls. Group differences in direct, outpatient and medication costs were statistically significant. Medication costs were 88% higher for T2D and had the highest share in direct excess costs. With respect to specific determinants, direct excess costs ranged from €203 for 4–10 years diabetes duration to €1405 for diabetes complications. Indirect excess costs ranged from €−544 for >10 years diabetes duration to €995 for high education.ConclusionsT2D was associated with high costs, mainly due to direct costs. As pointed out by our results, diabetes complications and comorbidities have a large impact on the costs, leaving medication costs as main contributor of T2D excess costs.
Testing for non-inferior mortality: a systematic review of non-inferiority margin sizes and trial characteristics
Authors: Pong Sandra , Urner Martin , Fowler Robert A , Mitsakakis Nicholas , Seto Winnie , Hutchison James S , Science Michelle , Daneman Nick 
Published: April 2021

ObjectiveTo describe the size and variability of non-inferiority margins used in non-inferiority trials of medications with primary outcomes involving mortality, and to examine the association between trial characteristics and non-inferiority margin size.DesignSystematic review.Data sourcesMedline, Medline In Process, Medline Epub Ahead of Print and Embase Classic+Embase databases from January 1989 to December 2019.Eligibility criteriaProspective non-inferiority randomised controlled trials comparing pharmacological therapies, with primary analyses for non-inferiority and primary outcomes involving mortality alone or as part of a composite outcome. Trials had to prespecify non-inferiority margins as absolute risk differences or relative to risks of outcome and provide a baseline risk of primary outcome in the control intervention.Results3992 records were screened, 195 articles were selected for full text review and 111 articles were included for analyses. 82% of trials were conducted in thrombosis, infectious diseases or oncology. Mortality was the sole primary outcome in 23 (21%) trials, and part of a composite primary outcome in 88 (79%) trials. The overall median non-inferiority margin was an absolute risk difference of 9% (IQR 4.2%–10%). When non-inferiority margins were expressed relative to the baseline risk of primary outcome in control groups, the median relative non-inferiority margin was 1.5 (IQR 1.3–1.7). In multivariable regression analyses examining the association between trial characteristics (medical specialty, inclusion of paediatric patients, mortality as a sole or part of a composite primary outcome, presence of industry funding) and non-inferiority margin size, only medical specialty was significantly associated with non-inferiority margin size.ConclusionAbsolute and relative non-inferiority margins used in published trials comparing medications are large, allowing conclusions of non-inferiority in the context of large differences in mortality. Accepting the potential for large increases in outcomes involving mortality while declaring non-inferiority is a challenging methodological issue in the conduct of non-inferiority trials.