bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Public Speaking Pemimpin Terhadap Kinerja Awak Kapal
Authors: Kuncowati Kuncowati , Wiyono S. Teguh 
Published: August 2021

Kemampuan pemimpin (Nakhoda, Kepala Kamar Mesin, Perwira deck dan Perwira mesin) pada saat dinas jaga di kapal tidak hanya memerlukan pengetahuan dan skill tetapi juga berbagai teori, teknik, metode dalam public speaking sehingga mampu berbicara, menyampaikan pesan, informasi maupun perintah ke anak buah dalam regu kerja dinas jaga di kapal dengan baik sehingga komunikasi berjalan lancar dan menghilangkan kesalahpahaman supaya kinerja di kapal yang telah ditargetkan tercapai. Penelitian ini bertujuan untuk menganalis pengaruh public speaking pemimpin terhadap kinerja awak kapal. Penelitian ini menggunakan metode kuantitatif dengan analisis regresi linier dengan uji – t. Respondent dalam penelitian ini adalah awak kapal niaga yang sedang berada di Pelabuhan Tanjung Perak Surabaya dengan jumlah 80 (delapan puluh) responden. Hasil dari penelitian berdasar regresi linier dan uji t adalah bahwa faktor public speaking pemimpin berpengaruh positif dan signifikan sebesar 0,610 satuan terhadap kinerja awak kapal dan berdasar uji determinasi diperoleh faktor public speaking pemimpin berpengaruh sebesar 37,1 % terhadap kinerja awak kapal.
Особливості соціально-економічного становища Волинської губернії під час Першої світової війни
Authors: Kovshun Nataliia , Mazur Nataliia , Tsetsyk Jaroslav 
Published: August 2021

У розвідці досліджено особливості соціально-економічного становища Волинської губернії під час Першої світової війни. Проаналізовано ключові фактори, які вплинули на погіршення рівня життя населення регіону, насамперед незаможних верств. Встановлено, що в результаті відступу російських військ у 1915 р. на Волині було проведено не лише евакуацію державних установ, підприємств, середніх навчальних закладів, а й примусово виселялося місцеве населення з прифронтових повітів. Така діяльність імперської влади призвела до зубожіння величезної кількості жителів регіону. Окрема увага приділена ролі органів міського самоуправління та земств у регулюванні цін на товари першої необхідності та наданні допомоги біженцям.
Епідеміологічна ситуація в Одесі у добу Гетьманату (по матеріалам одеських газет 1918 р.)
Authors: Kiazymova Halyna 
Published: August 2021

На основі аналізу одеської періодичної преси 1918 року розкрита санітарно-епідеміологічна ситуація в місті доби Гетьманату та спалах епідемії холери й «іспанки» у 1918 р. В умовах ще слабкої державної влади, війни та німецько-австрійської окупації центральний уряд не залишається осторонь, мобілізуючи організаційні та матеріальні можливості. Одеська міська влада та медичний персонал стають головною силою опору небезпеці, активно використовуючи усі доступні медичні, профілактичні та санітарні заходи.
Роль закарпатської політичної та духовної еліти у проголошенні «Карпатської України»
Authors: Sinitskyi Andrii 
Published: August 2021

У статті досліджено участь закарпатської політичної та духовної еліти у процесі проголошення, розбудови й захисту Карпатської України. Спираючись на принципи історизму, а також комплексності та наукової об’єктивності, автор статті здійснив осмислення конкретно-історичних передумов формування закарпатської політичної та духовної еліти у геополітичних процесах початку ХХ ст. Окреслено детермінуючі фактори, що спричинили особливості політичної диференціації та суспільної сегментації політичної еліти Закарпаття досліджуваного періоду, на основі чого здійснено характеристику сегментного складу та функціональних особливостей політичної й духовної еліти Закарпаття у період між двома світовими війнами.
Міністри-мусульмани у французьких урядах (2012-2017)
Authors: Sypko Bohdana 
Published: August 2021

У статті, на основі офіційного державного друкованого органу «Journal officiel de la République Française», звітів Сенату та Національної Асамблеї, матеріалів виступів, інтерв’ю та мемуарів проаналізовано склади французьких урядів періоду президентства Ф. Олланда та простежено, яку роль у них відігравали мусульмани. З’ясовано, що концептуальною для Ф. Олланда була злагодженість уряду, тому більшість міністрів-мусульман були членами Соціалістичної партії. Троє з чотирьох політиків народилися не у Франції, половина зберегла подвійне громадянство. Тому у риториці апелювали до культурного, релігійного й етнічного різноманіття Республіки, а питання історії, політики пам’яті, світськості, боротьби проти усіх форм дискримінації були ключовими.
«Епоха вікінгів»: сутність та основні підходи до вивчення
Authors: Zhyriakov Kostiantyn 
Published: August 2021

У статті розглянуто сутність дефініції «Епоха вікінгів» в історичній науці. Проаналізовано способи генезису та інтерпретації дефініції в історіографії.
Виявлено взаємозв’язок між методом інтерпретації дефініції та науковим підходом до проблематики «Епохи вікінгів». На основі аналізу історіографічних джерел встановлена хронологія вивчення «Епохи вікінгів». Виявлено характерні та загальні риси підходів у межах проблематики «Епохи вікінгів».
Писанкарство Поділля у рукописній спадщині 20-х років ХХ ст.
Authors: Tkachenko Viktor 
Published: August 2021

У статті розглянуто й оприлюднено архівні матеріали Інституту археології та Інституту мистецтвознавства, фольклористики та етнології імені М.Т. Рильського НАН України пов’язані з писанками. Зокрема, це листування Г.Т. Танцюри з Н.А. Коцюбинською, його записи, що стосуються великодньої обрядовості на Поділлі, а також рукописні матеріали фонду «Етнографічна комісія» ВУАН.
Невідомі широкому загалу, розглянуті джерела засвідчують існування писанок та їх використання під час великодніх звичаєво-обрядових традицій, у віруваннях українців 1920-х рр., збирання колекцій тощо.
Водночас епістолярна спадщина є цікавим і малодослідженим історичним джерелом.
Woman Existence in the Rural Population of Turkey
Authors: Şahin Güven 
Published: August 2021

The level of development throughout the world is explained on the basis of various criteria population are some of these development indicators. For many countries, the rural population and the characteristics of this population are accepted as an important indicator of development. Also, in Turkey, focusing the rural population particularly on the issue of rehabilitation since the founding of the Republic remained on the agenda. Indeed, the rural population in Turkey since the first years of the Republic showed a great change and transformation in terms of both quantitative and qualitative. The continuous contraction of the share of the rural population in the face of the urban population, the change in the rural labor force and finally some changes in the administrative sense, led to the situation of addressing the rural population and especially the female population from a significantly different perspective. Finally, in 2012, in accordance with Law No. 6360, Metropolitan Municipality 30 Metropolitan Municipalities organized in Turkey, rural population in these cities was adopted as 0 (zero). In addition to the many disadvantages of this situation, there are drawbacks to criticism in terms of ignoring the presence of women, which constitutes the largest part of the informal labor force in rural areas. It is debatable that rural women, who are deprived of their social rights and have a low level of awareness and quality of life, are inaccessible with the relevant law in comparison with the relatively urban women. In this study, the state of the overall presence of women in rural areas as a result of administrative arrangements with the relevant distribution in Turkey explained the outlines of the female population in the metropolitan municipalities in rural areas was discussed.
Etin Cinsel Politikası
Authors: Karabulut Müzeyyen 
Published: August 2021

Etin Cinsel Politikası, et yeme pratiği ile erkek egemenliği arasındaki ilişkiyi ve bu ilişkinin kadın ile insan olmayan diğer canlılar arasında kurduğu bağını zengin örneklerle sunan bir kitap. İddiası, et yeme pratiğinin beslediği erkek egemen kültürde tüm ezme biçimlerinin kayıp göndergelerle biribirini desteklediği yönünde. Kadınların kadın olmaları ile ilgili sömürülmelerinin ve hayvanların da dişi olduklarından dolayı çifte bir sömürüye, önce dişileştirilmiş protein, sonra ise hayvanlaştırılmış protein olarak iki kademeli bir zulme maruz bırakılmalarının göz ardı edilmesine yol açan ataerkil et yeme kültürü, savaşları da başlatan bir sebep olarak görülür. Etin Cinsel Politikası'nın tespitleri ve kavramsallaştırmalarının ele alınacağı bu yazıda, et yiyici egemen kültürlerin kadına ve hayvana yönelik baskısını çözümleyecek örnekler incelenecektir.
MCM5 Aggravates the HDAC1-Mediated Malignant Progression of Lung Cancer
Authors: Zhang Lin-lin , Li Qi , Zhong Dian-sheng , Zhang Wei-jian , Sun Xiao-jie , Zhu Yu 
Published: August 2021

BackgroundHistone deacetylase 1 (HDAC1) is essential in the malignant progression of tumors. However, there is no obvious relationship between the expression of HDAC1 and the survival of lung cancer patients. Herein, we explored the involvement of minichromosome maintenance complex component 5 (MCM5) and HDAC1 interaction in the epithelial-to-mesenchymal transition (EMT)-dependent malignant progression of lung cancer.MethodsWe analyzed the expression of MCM5 and HDAC1 in The Cancer Genome Atlas database and clinical samples, as well as their impact on patient survival. Cell and animal experiments were performed to verify the promotion of EMT in lung cancer cells mediated by MCM5 and HDAC1.ResultsWe found that lung adenocarcinoma patients with high expression of MCM5 and HDAC1 had poor survival time. Overexpression of MCM5 and HDAC1 in A549 and H1975 cells can promote proliferation and invasion in vitro and tumor growth and metastasis in vivo. Moreover, astragaloside IV can block the interaction between HDAC1 and MCM5, which can then inhibit the malignant progression of lung cancer in vivo and in vitro.ConclusionThe interaction between MCM5 and HDAC1 aggravated the EMT-dependent malignant progression of lung cancer. Astragaloside IV can block the interaction between MCM5 and HDAC1 to inhibit the progression of lung cancer.
Efficacy and Safety of High-Density Lipoprotein/Apolipoprotein A1 Replacement Therapy in Humans and Mice With Atherosclerosis: A Systematic Review and Meta-Analysis
Authors: Abudukeremu Ayiguli , Huang Canxia , Li Hongwei , Sun Runlu , Liu Xiao , Wu Xiaoying , Xie Xiangkun , Huang Jingjing , Zhang Jie , Bao Jinlan , Zhang Yuling 
Published: August 2021

Background: Although elevation of HDL-C levels by pharmaceutical drugs have no benefit of cardiovascular endpoint, the effect of high-density lipoprotein/apolipoprotein A1 (HDL/apoA-1) replacement therapy on atherosclerosis is controversial. The current meta-analysis analyzed the effects of HDL/apoA-1 replacement therapies on atherosclerotic lesions both in humans and mice.Methods: The PubMed, Cochrane Library, Web of Science, and EMBASE databases were searched through June 6, 2020. The methodological quality of the human studies was assessed using Review Manager (RevMan, version 5.3.). The methodological quality of the mouse studies was assessed using a stair list. STATA (version 14.0) was used to perform all statistical analyses.Results: Fifteen randomized controlled human trials and 17 animal studies were included. The pooled results showed that HDL/apoA-1 replacement therapy use did not significantly decrease the percent atheroma volume (p = 0.766) or total atheroma volume (p = 0.510) in acute coronary syndrome (ACS) patients (N = 754). However, HDL/apoA-1 replacement therapies were significantly associated with the final percent lesion area, final lesion area, and changes in lesion area (SMD, −1.75; 95% CI: −2.21~-1.29, p = 0.000; SMD, −0.78; 95% CI: −1.18~-0.38, p = 0.000; SMD: −2.06; 95% CI, −3.92~-0.2, p = 0.03, respectively) in mice.Conclusions: HDL/apoA-1 replacement therapies are safe but do not significantly improve arterial atheroma volume in humans. The results in animals suggest that HDL/apoA-1 replacement therapies decrease the lesion area. Additional studies are needed to investigate and explain the differences in HDL/apoA-1 replacement therapy efficacies between humans and animals.Trial registration number: Human pooled analysis: PROSPERO, CRD42020210772. prospectively registered.
Diminishing Opportunities for Sustainability of Coastal Cities in the Anthropocene: A Review
Authors: Day John W. , Gunn Joel D. , Burger Joseph Robert 
Published: August 2021

The world is urbanizing most rapidly in tropical to sub-temperate areas and in coastal zones. Climate change along with other global change forcings will diminish the opportunities for sustainability of cities, especially in coastal areas in low-income countries. Climate forcings include global temperature and heatwave increases that are expanding the equatorial tropical belt, sea-level rise, an increase in the frequency of the most intense tropical cyclones, both increases and decreases in freshwater inputs to coastal zones, and increasingly severe extreme precipitation events, droughts, freshwater shortages, heat waves, and wildfires. Current climate impacts are already strongly influencing natural and human systems. Because of proximity to several key warming variables such as sea-level rise and increasing frequency and intensity of heatwaves, coastal cities are a leading indicator of what may occur worldwide. Climate change alone will diminish the sustainability and resilience of coastal cities, especially in the tropical-subtropical belt, but combined with other global changes, this suite of forcings represents an existential threat, especially for coastal cities. Urbanization has coincided with orders of magnitude increases in per capita GDP, energy use and greenhouse gas emissions, which in turn has led to unprecedented demand for natural resources and degradation of natural systems and more expensive infrastructure to sustain the flows of these resources. Most resources to fuel cities are extracted from ex-urban areas far away from their point of final use. The urban transition over the last 200 years is a hallmark of the Anthropocene coinciding with large surges in use of energy, principally fossil fuels, population, consumption and economic growth, and environmental impacts such as natural system degradation and climate change. Fossil energy enabled and underwrote Anthropocene origins and fueled the dramatic expansion of modern urban systems. It will be difficult for renewable energy and other non-fossil energy sources to ramp up fast enough to fuel further urban growth and maintenance and reverse climate change all the while minimizing further environmental degradation. Given these trajectories, the future sustainability of cities and urbanization trends, especially in threatened areas like coastal zones in low-income countries in the tropical to sub-tropical belt, will likely diminish. Adaptation to climate change may be limited and challenging to implement, especially for low-income countries.
Long Noncoding RNAs as Emerging Regulators of COVID-19
Authors: Yang Qinzhi , Lin Fang , Wang Yanan , Zeng Min , Luo Mao 
Published: August 2021

Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical treatment of COVID-19, such as antivirals (radecivir, baritinib), monoclonal antibodies (tocilizumab), and glucocorticoids (dexamethasone). Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are essential regulators of virus infections and antiviral immune responses including biological processes that are involved in the regulation of COVID-19 and subsequent disease states. Upon viral infections, cellular lncRNAs directly regulate viral genes and influence viral replication and pathology through virus-mediated changes in the host transcriptome. Additionally, several host lncRNAs could help the occurrence of viral immune escape by inhibiting type I interferons (IFN-1), while others could up-regulate IFN-1 production to play an antiviral role. Consequently, understanding the expression and function of lncRNAs during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection will provide insights into the development of lncRNA-based methods. In this review, we summarized the current findings of lncRNAs in the regulation of the strong inflammatory response, immune dysfunction and thrombosis induced by SARS-CoV-2 infection, discussed the underlying mechanisms, and highlighted the therapeutic challenges of COVID-19 treatment and its future research directions.
Stormorken Syndrome Caused by a Novel STIM1 Mutation: A Case Report
Authors: Jiang Li-Jun , Zhao Xue , Dou Zhi-Yan , Su Qing-Xiao , Rong Zan-Hua 
Published: August 2021

Objective: To identify the gene mutation of Stormorken syndrome and review the published Stromal Interaction Molecule 1 (STIM1) mutation phenotype.Methods: We described the clinical and molecular aspects of a Chinese female with Stormorken syndrome by laboratory tests, muscle biopsies, and genetic analysis. We used this information to summarize all the mutation sites reported in the literature. We also reviewed the clinical features of published cases with a gain of function mutations of STIM1.Results: A 12-year-old Chinese female presented with skin purpura in the lower limbs and stroke-like episodes. Muscle biopsy and microscopic examination revealed atrophy in her skeletal muscle. Genetic analysis identified a novel heterozygous missense mutation, a c.1095G&gt;C transition (NM_003156.3), which caused a p.K365N amino acid substitution in the protein and affected a STIM1-orai1-activation region (SOAR).Conclusions: The novel variant c.1095G&gt;C transition (NM_003156.3) was located in the SOAR, which expands the phenotypic spectrum of STIM1 variants in human disorders and may define the molecular basis of Stormorken syndrome.
Using Base-ml to Learn Classification of Common Vestibular Disorders on DizzyReg Registry Data
Authors: Vivar Gerome , Strobl Ralf , Grill Eva , Navab Nassir , Zwergal Andreas , Ahmadi Seyed-Ahmad 
Published: August 2021

Background:Multivariable analyses (MVA) and machine learning (ML) applied on large datasets may have a high potential to provide clinical decision support in neuro-otology and reveal further avenues for vestibular research. To this end, we build base-ml, a comprehensive MVA/ML software tool, and applied it to three increasingly difficult clinical objectives in differentiation of common vestibular disorders, using data from a large prospective clinical patient registry (DizzyReg).Methods:Base-ml features a full MVA/ML pipeline for classification of multimodal patient data, comprising tools for data loading and pre-processing; a stringent scheme for nested and stratified cross-validation including hyper-parameter optimization; a set of 11 classifiers, ranging from commonly used algorithms like logistic regression and random forests, to artificial neural network models, including a graph-based deep learning model which we recently proposed; a multi-faceted evaluation of classification metrics; tools from the domain of “Explainable AI” that illustrate the input distribution and a statistical analysis of the most important features identified by multiple classifiers.Results:In the first clinical task, classification of the bilateral vestibular failure (N= 66) vs. functional dizziness (N= 346) was possible with a classification accuracy ranging up to 92.5% (Random Forest). In the second task, primary functional dizziness (N= 151) vs. secondary functional dizziness (following an organic vestibular syndrome) (N= 204), was classifiable with an accuracy ranging from 56.5 to 64.2% (k-nearest neighbors/logistic regression). The third task compared four episodic disorders, benign paroxysmal positional vertigo (N= 134), vestibular paroxysmia (N= 49), Menière disease (N= 142) and vestibular migraine (N= 215). Classification accuracy ranged between 25.9 and 50.4% (Naïve Bayes/Support Vector Machine). Recent (graph-) deep learning models classified well in all three tasks, but not significantly better than more traditional ML methods. Classifiers reliably identified clinically relevant features as most important toward classification.Conclusion:The three clinical tasks yielded classification results that correlate with the clinical intuition regarding the difficulty of diagnosis. It is favorable to apply an array of MVA/ML algorithms rather than a single one, to avoid under-estimation of classification accuracy. Base-ml provides a systematic benchmarking of classifiers, with a standardized output of MVA/ML performance on clinical tasks. To alleviate re-implementation efforts, we provide base-ml as an open-source tool for the community.
Computational Study of Hemodynamic Changes Induced by Overlapping and Compacting of Stents and Flow Diverter in Cerebral Aneurysms
Authors: Kim Sunghan , Yang Hyeondong , Hong Ineui , Oh Je Hoon , Kim Yong Bae 
Published: August 2021

Purpose: The flow diversion effect of an intracranial stent is closely related to its metal coverage rate (MCR). In this study, the flow diversion effects of Enterprise and low-profile visualized intraluminal support (LVIS) stents are compared with those of a Pipeline flow diverter, focusing on the MCR change. Moreover, the changes in the flow diversion effect caused by the additional manipulations of overlapping and compaction are verified using computational fluid dynamics (CFD) analysis.Methods: CFD analysis was performed using virtually generated stents mounted in an idealized aneurysm model. First, the flow diversion effects of single Enterprise, LVIS, and Pipeline devices were analyzed. The Enterprise and LVIS were sequentially overlapped and compared with a Pipeline, to evaluate the effect of stent overlapping. The effect of compacting a stent was evaluated by comparing the flow diversion effects of a single and two compacted LVIS with those of two overlapped, uncompacted LVIS and uncompacted and compacted Pipeline. Quantitative analysis was performed to evaluate the hemodynamic parameters of energy loss, average velocity, and inflow rate.Results: Statistically significant correlations were observed between the reduction rates of the hemodynamic parameters and MCR. The single LVIS without compaction induced a reduction in all the hemodynamic parameters comparable to those of the three overlapped Enterprise. Moreover, the two overlapped, uncompacted LVIS showed a flow diversion effect as large as that induced by the single uncompacted Pipeline. Compacted stents induced a better flow diversion effect than uncompacted stents. The single compacted LVIS induced a flow diversion effect similar to that induced by the two uncompacted LVIS or single uncompacted Pipeline.Conclusions: The MCR of a stent correlates with its flow diversion effect. Overlapping and compaction can increase the MCR of an intracranial stent and achieve a flow diversion effect as large as that observed with a flow diverter.