bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of myocardial hemorrhage and persistent microvascular obstruction with circulating inflammatory biomarkers in STEMI patients
Authors: Bochaton Thomas , Lassus Jules , Paccalet Alexandre , Derimay François , Rioufol Gilles , Prieur Cyril , Bonnefoy-Cudraz Eric , Crola Da Silva Claire , Bernelin Hugo , Amaz Camille , Espanet Sylvie , de Bourguignon Charles , Dufay Nathalie , Cartier Régine , Croisille Pierre , Ovize Michel , Mewton Nathan 
Published: January 2021

Introduction
Myocardial hemorrhage (IMH) and persistent microvascular obstruction (MVO) are associated with impaired myocardial recovery and adverse clinical outcomes in STEMI patients. However, their relationship with circulating inflammatory biomarkers is unclear in human patients.

Methods and results
Twenty consecutive patients referred for primary percutaneous coronary intervention of first STEMI were included in a prospective study. Blood sampling was performed at admission, 4, 12, 24, 48 hours, 7 and 30 days after reperfusion for inflammatory biomarker (C reactive protein, fibrinogen, interleukin-6 (IL-6) and neutrophils count) assessment. At seven days, cardiovascular magnetic resonance (CMR) was performed for infarct size, MVO and IMH assessment. Median infarct size was 24.6% Interquartile range (IQR) [12.0–43.5] of LV mass and edema was 13.2% IQR [7.7–36.1] of LV mass. IL-6 reached a peak at H24 (5.6 pg/mL interquartile range (IQR) [2.5–17.5]), CRP at H48 (11.7 mg/L IQR [7.1–69.2]), fibrinogen one week after admission (4.4 g/L IQR [3.8–6.7]) and neutrophils at H12 (9.0 G/L IQR [6.5–12.7]). MVO was present in 11 patients (55% of the study population) and hemorrhage in 7 patients (35%). Patients with IMH had significantly higher IL-6, CRP, fibrinogen, and neutrophils levels compared to patients without IMH. Patients with persistent MVO had significantly higher CRP, fibrinogen and neutrophils level compared to patients without MVO, but identical IL-6 kinetics.

Conclusion
In human patients with acute myocardial infarction, intramyocardial hemorrhage appears to have a stronger relationship with inflammatory biomarker release compared to persistent MVO. Attenuating myocardial hemorrhage may be a novel target in future adjunctive STEMI treatments.
Fine-scale distribution of malaria mosquitoes biting or resting outside human dwellings in three low-altitude Tanzanian villages
Authors: Mmbando Arnold S. , Kaindoa Emmanuel W. , Ngowo Halfan S. , Swai Johnson K. , Matowo Nancy S. , Kilalangongono Masoud , Lingamba Godfrey P. , Mgando Joseph P. , Namango Isaac H. , Okumu Fredros O. , Nelli Luca 
Published: January 2021

Background
While malaria transmission in Africa still happens primarily inside houses, there is a substantial proportion of Anopheles mosquitoes that bite or rest outdoors. This situation may compromise the performance of indoor insecticidal interventions such as insecticide-treated nets (ITNs). This study investigated the distribution of malaria mosquitoes biting or resting outside dwellings in three low-altitude villages in south-eastern Tanzania. The likelihood of malaria infections outdoors was also assessed.

Methods
Nightly trapping was done outdoors for 12 months to collect resting mosquitoes (using resting bucket traps) and host-seeking mosquitoes (using odour-baited Suna® traps). The mosquitoes were sorted by species and physiological states. Pooled samples of Anopheles were tested to estimate proportions infected with Plasmodium falciparum parasites, estimate proportions carrying human blood as opposed to other vertebrate blood and identify sibling species in the Anopheles gambiae complex and An. funestus group. Environmental and anthropogenic factors were observed and recorded within 100 meters from each trapping positions. Generalised additive models were used to investigate relationships between these variables and vector densities, produce predictive maps of expected abundance and compare outcomes within and between villages.

Results
A high degree of fine-scale heterogeneity in Anopheles densities was observed between and within villages. Water bodies covered with vegetation were associated with 22% higher densities of An. arabiensis and 51% lower densities of An. funestus. Increasing densities of houses and people outdoors were both associated with reduced densities of An. arabiensis and An. funestus. Vector densities were highest around the end of the rainy season and beginning of the dry seasons. More than half (14) 58.3% of blood-fed An. arabiensis had bovine blood, (6) 25% had human blood. None of the Anopheles mosquitoes caught outdoors was found infected with malaria parasites.

Conclusion
Outdoor densities of both host-seeking and resting Anopheles mosquitoes had significant heterogeneities between and within villages, and were influenced by multiple environmental and anthropogenic factors. Despite the high Anopheles densities outside dwellings, the substantial proportion of non-human blood-meals and absence of malaria-infected mosquitoes after 12 months of nightly trapping suggests very low-levels of outdoor malaria transmission in these villages.
Which indoor residual spraying insecticide best complements standard pyrethroid long-lasting insecticidal nets for improved control of pyrethroid resistant malaria vectors?
Authors: Syme Thomas , Fongnikin Augustin , Todjinou Damien , Govoetchan Renaud , Gbegbo Martial , Rowland Mark , Akogbeto Martin , Ngufor Corine 
Published: January 2021

Background
Where resources are available, non-pyrethroid IRS can be deployed to complement standard pyrethroid LLINs with the aim of achieving improved vector control and managing insecticide resistance. The impact of the combination may however depend on the type of IRS insecticide deployed. Studies comparing combinations of pyrethroid LLINs with different types of non-pyrethroid IRS products will be necessary for decision making.

Methods
The efficacy of combining a standard pyrethroid LLIN (DuraNet®) with IRS insecticides from three chemical classes (bendiocarb, chlorfenapyr and pirimiphos-methyl CS) was evaluated in an experimental hut trial against wild pyrethroid-resistant Anopheles gambiae s.l. in Cové, Benin. The combinations were also compared to each intervention alone. WHO cylinder and CDC bottle bioassays were performed to assess susceptibility of the local An. gambiae s.l. vector population at the Cové hut site to insecticides used in the combinations.

Results
Susceptibility bioassays revealed that the vector population at Cové, was resistant to pyrethroids (<20% mortality) but susceptible to carbamates, chlorfenapyr and organophosphates (≥98% mortality). Mortality of wild free-flying pyrethroid resistant An. gambiae s.l. entering the hut with the untreated net control (4%) did not differ significantly from DuraNet® alone (8%, p = 0.169). Pirimiphos-methyl CS IRS induced the highest mortality both on its own (85%) and in combination with DuraNet® (81%). Mortality with the DuraNet® + chlorfenapyr IRS combination was significantly higher than each intervention alone (46% vs. 33% and 8%, p<0.05) demonstrating an additive effect. The DuraNet® + bendiocarb IRS combination induced significantly lower mortality compared to the other combinations (32%, p<0.05). Blood-feeding inhibition was very low with the IRS treatments alone (3–5%) but increased significantly when they were combined with DuraNet® (61% - 71%, p<0.05). Blood-feeding rates in the combinations were similar to the net alone. Adding bendiocarb IRS to DuraNet® induced significantly lower levels of mosquito feeding compared to adding chlorfenapyr IRS (28% vs. 37%, p = 0.015).

Conclusions
Adding non-pyrethroid IRS to standard pyrethroid-only LLINs against a pyrethroid-resistant vector population which is susceptible to the IRS insecticide, can provide higher levels of vector mosquito control compared to the pyrethroid net alone or IRS alone. Adding pirimiphos-methyl CS IRS may provide substantial improvements in vector control while adding chlorfenapyr IRS can demonstrate an additive effect relative to both interventions alone. Adding bendiocarb IRS may show limited enhancements in vector control owing to its short residual effect.
Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia
Authors: Getaneh Dawit Kassaye , Hordofa Lemessa Oljira , Ayana Desalegn Admassu , Tessema Tesfaye Sisay , Regassa Lemma Demissie 
Published: January 2021

Background
Escherichia coli O157:H7 (E. coli O157:H7) is one of the most potent zoonotic pathogens that causes mild diarrhea and leads to hemolytic uremic syndrome or death. This study was aimed to assess the prevalence and determinants of E. coli O157:H7 related to diarrhea among under-five children with acute diarrhea.

Methods
A cross-sectional study design was carried out in 2018 on 378 under-five-year children recruited randomly from hospitals in Eastern Ethiopia. Stool specimens were collected and processed using enrichment, differential and selective medium. Among isolates, E. coli O157:H7 was confirmed using latex test (Oxoid, Basingstoke, Hants, England). Factors associated with E. coli O157:H7 infection were identified using binary and multivariable logistic regression. Associations were reported by odds ratio with 95% confidence interval.

Results
The prevalence of E. coli O157:H7 related diarrhea was 15.3% (95%CI: 11.8–19.5). The E. coli O157:H7 infection was positively associated with rural residence (AOR;3.75, 95%CI:1.26–11.20), consumption of undercooked meat (AOR;3.95, 95%CI: 1.23–12.67), raw vegetables and/or fruit juice (AOR;3.37, 95%CI:1.32–8.62), presence of bloody diarrhea (AOR;4.42, 95% CI:1.78–10.94), number of under-five children in a household (AOR;7.16, 95%CI: 2.90–17.70), presence of person with diarrhea in a household (AOR;4.22, 95% CI: 1.84–12.69), owning domestic animal (AOR;3.87, 95% CI: 1.48–10.12) and uneducated mother (AOR;3.14, 95%CI: 1.05–9.42).

Conclusion
The Prevalence of E. coli O157:H7 related diarrhea among under-five children is relatively high in Eastern Ethiopia. The E. coli infection was associated with sanitation and hygiene in a household. Thus, education focused on food cooking and handling, child care, and household sanitation associated with animal manure in rural resident children are helpful in.
Dementia and the risk of short-term readmission and mortality after a pneumonia admission
Authors: Graversen Susanne Boel , Pedersen Henrik Schou , Sandbaek Annelli , Foss Catherine Hauerslev , Palmer Victoria Jane , Ribe Anette Riisgaard 
Published: January 2021

Background
At time of discharge after a pneumonia admission, care planning for older persons with dementia is essential. However, care planning is limited by lack of knowledge on the short-term prognosis.

Aim
To investigate 30-day mortality and readmission after hospital discharge for pneumonia in persons with versus without dementia, and to investigate how these associations vary with age, time since discharge, and medication use.

Methods
Using the Danish registries, we investigated 30-day mortality and readmission in persons (+65 years) discharged after pneumonia in 2000–2016 (N = 298,872). Adjusted mortality rate ratios (aMRRs) and incidence rate ratios (aIRRs) were calculated for persons with versus without dementia, and we investigated if these associations varied with use of benzodiazepines, opioids, and antipsychotics, and with age and time since discharge.

Results
Among 25,948 persons with dementia, 4,524 died and 5,694 were readmitted within 30 days. The risk of 30-day mortality was 129% higher (95% CI 2.21–2.37) in persons with versus without dementia after adjustment for sociodemographic characteristics, admission-related factors, and comorbidities. Further, the highest mortality risk was found in persons with both dementia and use of antipsychotics (aMRR: 3.39, 95% CI 3.19–3.59); 16% of deaths in this group could not be explained by the independent effect of each exposure. In those with dementia, the highest aMRRs were found for the youngest and for the first days after discharge. The risk of 30-day readmission was 7% higher (95% CI 1.04–1.10) in persons with versus without dementia. In those with dementia, the highest aIRRs were found for the first days after discharge.

Conclusions
Dementia was associated with higher short-term mortality after pneumonia, especially in users of antipsychotics, and with slightly higher readmission, especially in the first days after discharge. This is essential knowledge in the care planning for persons with dementia who are discharged after a pneumonia admission.
A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models
Authors: Boyda Heidi N. , Procyshyn Ric M. , Tse Lurdes , Yuen Jessica W. Y. , Honer William G. , Barr Alasdair M. 
Published: January 2021

Background
The second generation antipsychotic drugs represent the most common form of pharmacotherapy for schizophrenia disorders. It is now well established that most of the second generation drugs cause metabolic side-effects. Risperidone and its active metabolite paliperidone (9-hydroxyrisperidone) are two commonly used antipsychotic drugs with moderate metabolic liability. However, there is a dearth of preclinical data that directly compares the metabolic effects of these two drugs, using sophisticated experimental procedures. The goal of the present study was to compare metabolic effects for each drug versus control animals.

Methods
Adult female rats were acutely treated with either risperidone (0.1, 0.5, 1, 2, 6 mg/kg), paliperidone (0.1, 0.5, 1, 2, 6 mg/kg) or vehicle and subjected to the glucose tolerance test; plasma was collected to measure insulin levels to measure insulin resistance with HOMA-IR. Separate groups of rats were treated with either risperidone (1, 6 mg/kg), paliperidone (1, 6 mg/kg) or vehicle, and subjected to the hyperinsulinemic euglycemic clamp.

Results
Fasting glucose levels were increased by all but the lowest dose of risperidone, but only with the highest dose of paliperidone. HOMA-IR increased for both drugs with all but the lowest dose, while the three highest doses decreased glucose tolerance for both drugs. Risperidone and paliperidone both exhibited dose-dependent decreases in the glucose infusion rate in the clamp, reflecting pronounced insulin resistance.

Conclusions
In preclinical models, both risperidone and paliperidone exhibited notable metabolic side-effects that were dose-dependent. Differences between the two were modest, and most notable as effects on fasting glucose.
¿Quién tiene derecho a recordar? Las disputas por la memoria durante los gobiernos kirchneristas (Argentina, 2003-2015)
Authors: Bale Cinthia 
Published: January 2021

El artículo se propone abordar las principales disputas que tuvieron lugar en Argentina frente al involucramiento del Estado en la formulación de “políticas de memoria” durante los gobiernos de Néstor Kirchner y Cristina Fernández de Kirchner (2003-2015). Para ello, nos detendremos en las discusiones que tuvieron lugar en el Congreso Nacional en ocasión de la construcción de un Museo en el ex Centro Clandestino de Detención ESMA. Analizaremos las principales críticas formuladas por la oposición partidaria en clave de “ilegitimidad”, “apropiación” y “banalización” de la memoria. La reconstrucción de estos argumentos y las respuestas esgrimidas por el oficialismo nos permitirán dar cuenta de los términos en que se desarrolló la disputa política por el pasado e introducir algunas consideraciones en torno del papel otorgado al “consenso” como modo de legitimación de la acción estatal en la materia.¿Who is entitled to remember? Memory conflicts during Kirchner and Fernández de Kirchner’s administrations in Argentina (2003-2015).The articleanalyses the main memory conflicts that took place in Argentina vis- à-vis the State involvement in memory politics during Néstor Kirchner and Fernández de Kirchner’s administrations (2003-2015). To this effect, it examines some of the debates held in the national parliament concerning the construction of a museum at the ex- clandestine detention center ESMA. It goes over the main critiques made by the political opposition (expressed in terms of “illegitimacy”, “appropriation” and “trivialization of memories”) and the responses held by the government. Altogether, this analysis will show the way in which the political arena dealt with the past in contemporary Argentina and will allow us to introduce some consideration Key words: Memory politics, Kirchnerism, State, ESMA
Evaluation of Rock Abrasiveness Based on a Digital Drilling Test
Authors: Wang Yujie , Cao Ruilang , She Lei , Zhao Yufei , Pi Jin 
Published: January 2021

AbstractThe accurate evaluation of rock abrasiveness is the basis for the cutting tool design of tunnel boring machines and efficient tunneling. However, the conventional test method is complicated and costly, and in situ measurement cannot be obtained easily. A new digital drilling test system was developed to assess rock abrasiveness in which drilling parameters, including the thrust on bit, rotational speed, torque, and drilling displacement, can be simultaneously collected. Based on the force analysis of the drill bit and the energy conservation law, the energy dissipation per unit volume of drilling or modified specific energy was proposed as an evaluation index, and the quantitative relationship between the index and rock abrasiveness was explored and verified. The results showed that the average difference rate between the Cerchar abrasiveness indexes obtained from the digital drilling test and Cerchar test was less than 15 %, thus proving the effectiveness and feasibility of this method for evaluating rock abrasiveness. The method is easy to implement and has few requirements for sample preparation. It can also be used for the in situ testing of rock abrasiveness in engineering sites.
Early Motor Function of Children With Autism Spectrum Disorder: A Systematic Review
Authors: Lim Yi Huey , Licari Melissa , Spittle Alicia J. , Watkins Rochelle E. , Zwicker Jill G. , Downs Jenny , Finlay-Jones Amy 
Published: January 2021

CONTEXT:Early motor impairments have been reported in children with neurodevelopmental disorders (NDD), but it is not clear if early detection of motor impairments can identify children at risk for NDD or how early such impairments might be detected.OBJECTIVE:To characterize early motor function in children later diagnosed with NDD relative to typically developing children or normative data.DATA SOURCES:The Cumulative Index to Nursing and Allied Health Literature, Embase, Medline, PsycINFO, and Scopus electronic databases were searched.STUDY SELECTION:Eligible studies were required to include an examination of motor function in children (0–24 months) with later diagnosis of NDD by using standardized assessment tools.DATA EXTRACTION:Data were extracted by 4 independent researchers. The quality of the studies was assessed by using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields checklist.RESULTS:Twenty-five studies were included in this review; in most of the studies, the authors examined children with later autism spectrum disorder (ASD). Early motor impairments were detected in children later diagnosed with ASD. The meta-analysis results indicated that differences in fine, gross, and generalized motor functions between the later ASD and typically developing groups increased with age. Motor function across different NDD groups was found to be mixed.LIMITATIONS:Results may not be applicable to children with different types of NDD not reported in this review.CONCLUSIONS:Early motor impairments are evident in children later diagnosed with ASD. More research is needed to ascertain the clinical utility of motor impairment detection as an early transdiagnostic marker of NDD risk.
HAK ASUH ANAK AKIBAT CERAI GUGAT DALAM PERKARA NOMOR 0915/Pdft.G/2017/PA.Bgr
Authors: Arnengsih A , Sururie Ramdani Wahyu 
Published: January 2021

ABSTRACT This research is motivated by the existence of an Application for Divorce Claims in Bogor Religious Court ruling as an Applicant filing for Claims Divorce and Child Custody. The Plaintiff as a mother filed a lawsuit to the Bogor Religious Court so that Child Custody fell on the Plaintiff. But the Defendant as the father is suing back, that the child custody holder is his father because his mother does not reflect as a good mother. Then the Board of Judges of the Bogor Religious Court rejected the Plaintiff's claim and granted the Defendant's claim to establish custody of the child at the Defendant until the child is 14 years old provided that the plaintiff is given access to meet the child. This study aims to determine the legal basis of the Panel of Judges, the method of finding the Panel of Judges in child custody cases. The results of this study are: 1. The consideration of the panel of judges granted the Defendant's lawsuit because he saw from the facts in the trial and based on the evidence submitted by the parties and looked at the benefit of the child. 2. Judges use the method of legal construction in legal discovery, namely the method of law enforcement (rechtsvervjnings). In this method, the judge can rule out articles that are deemed incompatible with the facts at this time.