bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatores que influenciam para transferência do cuidado intra-hospitalar efetiva: Revisão integrativa
Authors: Mello Thailini Silva de , Miorin Jeanini Dalcol , Camponogara Silviamar , Paula Cristiane Cardoso de , Pinno Camila , Freitas Etiane de Oliveira 
Published: July 2021

Objetivo: identificar na literatura os fatores que influenciam para realização da transferência do cuidado intra-hospitalar efetiva pela equipe de enfermagem. Metodologia: trata-se de uma revisão integrativa de literatura, realizada em três bases de dados: Web of Science, Medical Literature Analysis and Retrieval System Online (MEDLINE) e Sci Verse Scopus (SCOPUS). Foram incluídos estudos primários, em português, espanhol ou inglês, publicados entre os anos de 2015 a 2021. Resultados: a análise criteriosa dos 39 estudos internacionais possibilitou identificar que a realização de transferências relacionadas a pacientes adultos e pediátricos e realizadas por meio do deslocamento ou não do paciente no ambiente intra-hospitalar sofrem influência de fatores como a comunicação, transporte, trabalho em equipe e educação em saúde e estes repercutem na efetividade da transferência do cuidado intra-hospitalar. Conclusão: diante da análise dos estudos encontrados nota-se a comunicação como um fator predominante, embora os fatores transporte, trabalho em equipe e educação em saúde também apresentam características significativas que influenciam na realização da transferência do cuidado intra-hospitalar efetiva.
Hypomethylation of Rnase6 Promoter Enhances Proliferation and Migration of Murine Aortic Vascular Smooth Muscle Cells and Aggravates Atherosclerosis in Mice
Authors: Fang YongPeng , Li JinShuang , Niu XuDong , Ma NingShun , Zhao Jia 
Published: July 2021

Background: Accumulating evidence has implicated DNA methylation in the progression of atherosclerosis (AS). Rnase6 has been reported to be upregulated in AS development, but the specific regulatory mechanism remains unclear.Material/Methods: Peripheral blood and sclerotic plaque tissues from 25 AS patients were collected to detect Rnase6 expression. Methylation-specific polymerase chain reaction (MSP) was used to detected Rnase6 methylation levels in the peripheral blood of AS patients. Rnase6 expression was knocked down or DNA methyltransferase 1 (DNMT1) was overexpressed in OX-LDL-treated mouse aortic smooth muscle cells (MOVAS), and cell proliferation, migration, ROS content, and inflammatory factor secretion levels were detected. 740 Y-P, a PI3K specific agonist, was introduced to verify the effect of Rnase6 promoter hypomethylation on the PI3K/Akt signaling pathway. We knocked down Rnase6 expression in ApoE−/− mice fed with a high-fat diet to examine Rnase6 promoter methylation levels. Plaque areas and inflammatory factor secretion were examined in AS mice overexpressing DNMT1.Results: Rnase6 expression was upregulated in the peripheral blood and plaque tissues of AS patients, accompanied by decreased methylation levels of the Rnase6 promoter. Interfering with Rnase6 expression or overexpressing DNMT1 in OX-LDL stimulated MOVAS inhibited cell proliferation and migration, decreased ROS content and inflammatory factor secretion, and inhibited PI3K pathway protein expression. Rnase6 expression was decreased in the peripheral blood and plaque tissues of si-Rnase6-injected mice, and Rnase6 promoter methylation was increased. Mice overexpressing DNMT1 showed less plaque areas in the aortic root and lower secretion levels of inflammatory factors.Conclusion: Hypomethylation of the promoter of Rnase6 enhanced the proliferation and migration of OX-LDL treated MOVAS, upregulated ROS content and inflammatory factor secretion levels in the cells, and activated the PI3K/Akt signaling pathway.
Differential Evaluating Effect on Exercise Capacity of Cardiopulmonary Exercise Testing and Treadmill Exercise Testing in Post-percutaneous Coronary Intervention Patients
Authors: Gao Yifan , Feng Bin , Hu Rong , Zhang YingYue , Shi Yajun , Xu Yong , Ma Jing 
Published: July 2021

Background:Treadmill exercise testing (TET) is commonly used to measure exercise capacity. Studies have shown that cardiopulmonary exercise testing (CPET) is more accurate than TET and is, therefore, regarded as the “gold standard” for testing maximum exercise capacity and prescribing exercise plans. To date, no studies have reported the differences in exercise capacity after percutaneous coronary intervention (PCI) using the two methods or how to more accurately measure exercise capacity based on the results of TET.Aims:This study aims to measure maximum exercise capacity in post-PCI patients and to recommend exercise intensities that ensure safe levels of exercise.Methods:We enrolled 41 post-PCI patients who were admitted to the Cardiac Rehabilitation Clinic at the First Medical Center, the Chinese PLA General Hospital, from July 2015 to June 2016. They completed CPET and TET. The paired samplet-test was used to compare differences in measured exercise capacity, and multiple linear regression was applied to analyze the factors that affected the difference.Results:The mean maximum exercise capacity measured by TET was 8.89 ± 1.53 metabolic equivalents (METs), and that measured by CPET was 5.19 ± 1.23 METs. The difference between them was statistically significant (p= 0.000) according to the paired samplet-test. The difference averaged 40.15% ± 2.61% of the exercise capacity measured by TET multiple linear regression analysis showed that the difference negatively correlated with waist-hip ratio (WHR).Conclusion:For the purpose of formulating more accurate exercise prescription, the results of TET should be appropriately adjusted when applied to exercise capacity assessment.Clinical Trial Registration:http://www.chictr.org.cn/number, ChiCTR2000031543.
Orbital Influence on Precipitation, Fire, and Grass Community Composition From 1.87 to 1.38 Ma in the Turkana Basin, Kenya
Authors: Yost Chad L. , Lupien Rachel L. , Beck Catherine , Feibel Craig S. , Archer Steven R. , Cohen Andrew S. 
Published: July 2021

The Turkana Basin in northern Kenya and southern Ethiopia has yielded hundreds of hominin fossils and is among the most important localities in the world for studying human origins. High resolution climate and vegetation reconstructions from this region can elucidate potential linkages between hominin evolution and environmental change. Microcharcoal and phytoliths were examined from a 216 m (1.87–1.38 Ma) drill core (WTK13), which targeted paleo-Lake Lorenyang sediments from the Nachukui Formation of the Turkana Basin. A total of 287 samples were analyzed at ∼32–96 cm intervals, providing millennial-scale temporal resolution. To better understand how basin sediments record fire and vegetation from the watershed, the paleorecord was compared with nine modern sediment samples collected from Lake Turkana along a transect of increasing distance from the 1978 to 1979 shoreline. This included vegetation surveys and phytolith production data for species from areas proximal to the basin. We found that phytolith and microcharcoal concentrations decreased predictably moving off shore. However, phytoliths from plants sourced in the Ethiopian Highlands increased moving off shore, likely the result of increased exposure to the Omo River sediment plume. In our down-core study, microcharcoal was well-preserved but phytolith preservation was poor below ∼60 m (∼1.50 Ma). Spectral analysis revealed that microcharcoal often varied at precessional (∼21 kyr) periodicities, and through a correlation with δDwax, linked orbitally forced peaks in precipitation with elevated fire on the landscape. Phytoliths revealed that alternating mesic C4 versus xeric C4 grass dominance likely varied at precessional periodicities as well, but that grass community composition was also mediated by basin geometry. Two high eccentricity intervals of particularly high amplitude and abrupt environmental change were centered at ∼1.72 and 1.50 Ma, with the intervening period experiencing high fire variability. With the switch from lacustrine to fluvial-deltaic deposition at the core site by 1.5 Ma, mesic C4 grasses dominated and fire activity was high. This upper interval correlated to the time interval from which Nariokotome Boy (Homo erectus/ergaster) was discovered 3 km east of our drill site. Phytoliths indicated a seasonally wet and open landscape dominated by xeric C4 grasses, sedges, and other herbaceous plants.
The Protective Effect of Metformin on Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis
Authors: Yuan Zhen , Heng Zhijian , Lu Yi , Wei Jia , Cai Zhejun 
Published: July 2021

BackgroundType 2 diabetes mellitus (T2DM) patients have a lower risk of abdominal aortic aneurysm (AAA) and its comorbidities, which might be associated with the usage of metformin. The objective of the study was to evaluate the role of metformin in the process of AAA development.MethodPubMed, Embase and Cochrane Library were searched up to May 15th, 2021. We implemented several methods including the risk of bias graph, GRADE system and funnel plot to assess the quality and possible bias of this study. Subgroup analysis and sensitivity analysis were applied to address quality differences and validate the robustness of the final results.ResultTen articles were enrolled after screening 151 articles searched from databases. The pooled results showed that, compared with T2DM patients without metformin, metformin prescription was associated with a slower annual growth rate of the aneurysm (mean difference (MD) -0.67 cm [95% confidence interval (CI) -1.20 ~ -0.15 cm]). Besides, metformin exposure was associated with a lower frequency of AAA events (odds ratio (OR) 0.61 [95% CI 0.41-0.92]).ConclusionMetformin alleviated both annual expansion rate and aneurysm rupture frequency in AAA patients with T2DM.Systematic Review RegistrationPROSPERO, identifier https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=217859 (CRD42020217859).
A High-Precision and Wideband Fundamental Frequency Measurement Method for Synchronous Sampling Used in the Power Analyzer
Authors: Wang Yifan , Chen Kai , Gou Xuan , He Renjun , Zhou Wenjian , Yang Sheng , Qiu Gen 
Published: July 2021

In the dedicated high-precision power quality analyzer, synchronous sampling is required to reduce the effect of spectrum leakage produced by the discrete Fourier transform process. Thus, accurate fundamental frequency measurement is urgently needed. However, due to the harmonics and noise in the power signal, it is difficult to achieve the accurate fundamental frequency measurement. Moreover, with the wide application of high-frequency programmable power supply, the fundamental frequency is gradually increasing, which requires power analyzers to have the abilities of both high precision and a wide range of the fundamental frequency measurement. To solve these issues, a new fundamental frequency measurement architecture used in synchronous sampling is proposed. This architecture consists of a small-point fast Fourier transform module, spectrum refinement algorithm, and a multimodal optimization method to calculate the accurate fundamental frequency under large harmonic conditions. In the practical hardware platform results, this architecture has a large fundamental frequency measurement range from 20 Hz to 200 kHz with a relative error which is &lt;0.004%. The wideband fundamental frequency measurement structure proposed in this article achieves high measurement accuracy.
Torrefied Biomass and Where Is the Sector Currently Standing in Terms of Research, Technology Development, and Implementation
Authors: Wild Michael , Calderón Cristina 
Published: July 2021

Torrefaction is a thermal conversion method of biomass used to produce a high-quality solid biofuel that can be used for combustion, gasification, and additional non–energy-related applications. Torrefied biomass has numerous advantages above today’s standard biomass fuels like log wood, wood chips, and white wood pellets (WWPs). This is known and promoted for long, and has been proven in numerous research and demonstration projects; however, large-scale industrial proof is still underway only in these days. First, project implementations with name plate capacity of 100 kmt/a or higher are in construction or hot commissioning. In this review, the main advantages of torrefaction are shortly described, and the latest industry developments and future opportunities for the products as well as areas of need for further R&amp;D are presented.
Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection
Authors: Zhang Wen , Fu Zhendong , Yin Hongyan , Han Qingbing , Fan Wenhui , Wang Fangkun , Shang Yingli 
Published: July 2021

Polarization of macrophages to different functional states is important for mounting responses against pathogen infections. Macrophages are the major target cells of porcine circovirus type 2 (PCV2), which is the primary causative agent of porcine circovirus–associated disease (PCVAD) leading to immense economic losses in the global swine industry. Clinically, PCV2 is often found to increase risk of other pathogenic infections yet the underlying mechanisms remain to be elusive. Here we found that PCV2 infection skewed macrophages toward a M1 status through reprogramming expression of a subset of M1-associated genes and M2-associated genes. Mechanistically, induction of M1-associated genes by PCV2 infection is dependent on activation of nuclear factor kappa B (NF-κB) and c-jun N-terminal kinase (JNK) signaling pathways whereas suppression of M2-associated genes by PCV2 is via inhibiting expression of jumonji domain containing-3 (JMJD3), a histone 3 Lys27 (H3K27) demethylase that regulates M2 activation of macrophages. Finally, we identified that PCV2 capsid protein (Cap) directly inhibits JMJD3 transcription to restrain expression of interferon regulatory factor (IRF4) that controls M2 macrophage polarization. Consequently, sustained infection of PCV2 facilitates bacterial infection in vitro. In summary, these findings showed that PCV2 infection functionally modulated M1 macrophage polarization via targeting canonical signals and epigenetic histone modification, which contributes to bacterial coinfection and virial pathogenesis.
High Frequency Occult Hepatitis B Virus Infection Detected in Non-Resolved Donations Suggests the Requirement of Anti-HBc Test in Blood Donors in Southern China
Authors: Ye Xianlin , Zhao Yu , Li Ran , Li Tong , Zheng Xin , Xiong Wen , Zeng Jinfeng , Xu Min , Chen Limin 
Published: July 2021

BackgroundMost Chinese Blood Centers adopted mini pool (MP) nucleic acid testing (NAT) for HBV screening due to high cost of Individual donation (ID) NAT, and different proportions of MP-reactive but ID-non-reactive donations (MP+/ID−, defined as non-resolved donations) have been observed during daily donor screening process. Some of these non-resolved donations are occult HBV infections (OBIs), which pose potential risk of HBV transmission if they are not deferred. This study is aimed to further analyze these non-resolved donations.MethodsThe non-resolved plasma samples were further analyzed by serological tests and various HBV DNA amplification assays including quantitative PCR (qPCR) and nested PCR amplifying the basic core and pre-core promoter regions (BCP/PC; 295 base pairs) and HBsAg (S) region (496 base pairs). Molecular characterizations of HBV DNA+ non-resolved samples were determined by sequencing analysis.ResultsOf 17,226 MPs from 103,356 seronegative blood donations, 98 MPs were detected reactive for HBV. Fifty-six out of these 98 (57.1%) reactive MPs were resolved as HBV DNA+, but the remaining 42 pools (42.9%, 252 donations) were left non-resolved with a high rate (53.2%) of anti-HBc+. Surprisingly, among 42 non-resolved MPs, 17 contained one donation identified as OBIs by alternative NAT assays. Sequence analysis on HBV DNAs extracted from these OBI donations showed some key mutations in the S region that may lead to failure in HBsAg detection and vaccine escape.ConclusionA total of 53.2% of the non-resolved donations were anti-HBc+, and OBIs were identified in 40.5% of these non-resolved pools. Therefore, non-resolved donations with anti-HBc+ might pose potential risk for HBV transmission. Our present analysis indicates that anti-HBc testing in non-resolved donations should be used to identify OBIs in order to further increase blood safety in China.
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses
Authors: Zheng Wenjiang , Wu Hui , Liu Chengxin , Yan Qian , Wang Ting , Wu Peng , Liu Xiaohong , Jiang Yong , Zhan Shaofeng 
Published: July 2021

BackgroundThe outbreak of Coronavirus disease 2019 (COVID-19) has become an international public health crisis, and the number of cases with dengue co-infection has raised concerns. Unfortunately, treatment options are currently limited or even unavailable. Thus, the aim of our study was to explore the underlying mechanisms and identify potential therapeutic targets for co-infection.MethodsTo further understand the mechanisms underlying co-infection, we used a series of bioinformatics analyses to build host factor interaction networks and elucidate biological process and molecular function categories, pathway activity, tissue-specific enrichment, and potential therapeutic agents.ResultsWe explored the pathologic mechanisms of COVID-19 and dengue co-infection, including predisposing genes, significant pathways, biological functions, and possible drugs for intervention. In total, 460 shared host factors were collected; among them, CCL4 and AhR targets were important. To further analyze biological functions, we created a protein-protein interaction (PPI) network and performed Molecular Complex Detection (MCODE) analysis. In addition, common signaling pathways were acquired, and the toll-like receptor and NOD-like receptor signaling pathways exerted a significant effect on the interaction. Upregulated genes were identified based on the activity score of dysregulated genes, such as IL-1, Hippo, and TNF-α. We also conducted tissue-specific enrichment analysis and found ICAM-1 and CCL2 to be highly expressed in the lung. Finally, candidate drugs were screened, including resveratrol, genistein, and dexamethasone.ConclusionsThis study probes host factor interaction networks for COVID-19 and dengue and provides potential drugs for clinical practice. Although the findings need to be verified, they contribute to the treatment of co-infection and the management of respiratory disease.
Liver Stiffness Is a Predictor of Rebleeding in Patients With Hepatitis B-Related Cirrhosis: A Real-World Cohort Study
Authors: Liu Linxiang , Nie Yuan , Zhang Yue , Liu Qi , Zhu Xuan 
Published: July 2021

Background: Esophageal vein rebleeding is a life-threatening complication of liver cirrhosis. However, the role of non-invasive methods that were developed to evaluate the severity of chronic liver disease, especially in rebleeding, remains unclear.Aims: To evaluate the performance of liver stiffness and non-invasive fibrosis scores in predicting esophageal vein rebleeding in hepatitis B virus (HBV) cirrhotic patients.Methods: A prospective analysis of 194 HBV patients between 2017 and 2021 was performed. Receiver operating characteristic (ROC) curves and time-dependent ROC curves were used to assess the power for predicting rebleeding with non-invasive fibrosis score and liver stiffness.Results: During the median follow-up time of 68.28 weeks, 55 patients experienced rebleeding. In the entire cohort, the area under the ROC curve for liver stiffness measurement (LSM) predicting for rebleeding was 0.837, with a cut-off value of 17.79 kPa, and the time-dependent ROC curve also showed stable prediction performance of LSM. The predictive ability of the non-invasive fibrosis score was less than that of LSM, and there were statistical differences. Moreover, patients using non-selective beta-blockers and HBV DNA-negative patients experienced significantly reduced rebleeding.Conclusions: Compared with non-invasive fibrosis scores, LSM can more simply and accurately predict rebleeding events of hepatitis B liver cirrhosis.
Systematic Review Estimating the Burden of Dementia in the Latin America and Caribbean Region: A Bayesian Approach
Authors: Xiang Yawen , Vilmenay Kimberly , Poon Adrienne N. , Ayanian Shant , Aitken Christopher F. , Chan Kit Yee 
Published: July 2021

Background: The global burden of dementia has increasingly shifted to low- and middle-income regions that lack essential data for monitoring epidemiological progression, and policy and planning support. Drawing upon data that have emerged since the last known estimates published in 2015, this study aims to update dementia estimates in the Latin America and Caribbean (LAC) region for the years 2020, 2030, and 2050 through the application of a recently validated Bayesian approach for disease estimates useful when data sources are scarce.Methods: A comprehensive parallel systematic review of PubMed, EMBASE, PsycINFO, Global Health, and LILACS was conducted to identify prospective population-based epidemiological studies on dementia published in English from 2013 to 2018 in LAC. English and non-English data cited by a recent review on dementia estimates in LAC were also examined for additional data. A Bayesian normal-normal hierarchical model (NNHM) was developed to estimate age-specific and age-adjusted dementia prevalence in people aged 60+. Using age-specific population projections from the UN, the total number of people affected by dementia for the years 2020, 2030, and 2050 were estimated.Results: 1,414 studies were identified, of which only 7 met the inclusion criteria. The studies had 7,684 participants and 1,191 dementia cases. The age-standardized prevalence of all forms of dementia in LAC was 8% (95% CI: 5–11.5%) in people aged 60+. The estimated prevalence varied with age, increasing from 2.5% (95% CI: 0.08–4.0%) in the 60-69 age group, to 9.4% (95% CI: 5.4–13.2%) in the 70–79 age group and 28.9% (95% CI: 20.3–37.2%) in the ≥80 age group. The number of people age 60 and older living with dementia in LAC in 2020 was estimated at 6.86 (95% CI: 4.3–9.8) million, 9.94 (95% CI: 6.16–14.15) million in 2030, and 19.33 (95% CI: 12.3–13.6) million in 2050.Conclusion: We project an upward disease trajectory for dementia in LAC countries. The projection is likely an underestimation of the true dementia burden given the underrepresentation of rural and socio-economically deprived populations. More research is urgently needed to improve the accuracy of disease estimates, guide clinicians to improve evaluations for earlier recognition of dementia, and support the development of effective policies for improving dementia prevention, diagnosis and clinical management in LAC's diverse and aging communities.