bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization
Authors: Wang Chong , Leong Merrin Manlong , Ding Weiyue , Narita Yohei , Liu Xiang , Wang Hongbo , Yiu Stefanie P T , Lee Jessica , Zhao Katelyn R S , Cui Amy , Gewurz Benjamin , Hammerschmidt Wolfgang , Teng Mingxiang , Zhao Bo 
Published: January 2025

Abstract
The Epstein–Barr virus (EBV) nuclear antigen leader protein (EBNALP) is essential for the immortalization of naive B lymphocytes (NBLs). However, the mechanisms remain elusive. To understand EBNALP’s role in B-cell transformation, we compare NBLs infected with wild-type EBV and an EBNALP-null mutant EBV using multi-omics techniques. EBNALP inactivation alters enhancer–promoter interactions, resulting in decreased CCND2 and increased CASP1 and BCL2L11 expression. Mechanistically, EBNALP interacts with and colocalizes with the looping factor YY1. Depletion of EBNALP reduces YY1 DNA-binding and enhancer–promoter interactions, similar to effects observed with YY1 depletion. Furthermore, EBNALP colocalizes with DPF2, a protein that binds to H3K14ac and H4K16ac. CRISPR depletion of DPF2 reduces both EBNALP and YY1 DNA binding, suggesting that the DPF2/EBNALP complex may tether YY1 to DNA to increase enhancer–promoter interactions. EBNALP inactivation also increases enhancer–promoter interactions at the CASP1 and BCL2L11 loci, along with elevated DPF2 and YY1 binding and DNA accessibility. Our data suggest that EBNALP regulates YY1 to rewire the host genome, which might facilitate naive B-cell transformation.
A therapeutic regimen using neoantigen-specific TCR-T cells for HLA-A*2402-positive solid tumors
Authors: Bei Yuncheng , Huang Ying , Wu Nandie , Li Yishan , Xu Ruihan , Liu Baorui , Li Rutian 
Published: January 2025

Abstract
The adoptive transfer of TCR-T cells specific to neoantigens preferentially exhibits potent cytotoxicity to tumor cells and has shown promising efficacy in various preclinical human cancers. In this study, we first identified a functional TCR, Tcr-1, which selectively recognized the SYT-SSX fusion neoantigen shared by most synovial sarcomas. Engineered T-cell expressing Tcr-1 (Tcr-T1) demonstrated HLA-A*2402-restricted, antigen-specific anti-tumoral efficacy against synovial sarcoma cells, both in vitro and in vivo. Furthermore, to extend its application, we developed a cooperative therapeutic modality, in which exogenous SYT-SSX fusion neoantigen was loaded into stimuli-responsive nanoparticles (NPs) formed by mPEG-PVGLIG-PCL copolymers (Neo-AgNPs) for tumor targeting delivery. As expected, Neo-AgNPs were proven to have great tumor penetration and local release. In situ, the modification was able to direct engineered Tcr-T1 against other HLA-A*2402-positive malignant cancer cell lines with significant antigen-specific cytotoxicity despite their inherent mutation profiles. With these favorable data, our established cooperative therapeutic modality has great potential for further clinical investigation and provides new insight for future TCR-T cell therapy development.
Spherical bias in the 3D reconstruction of the ICM density profile in galaxy clusters
Authors: Veronesi I. , Bartalucci I. , Rasia E. , Molendi S. , Balboni M. , De Grandi S. , Gastaldello F. , Grillo C. , Ghizzardi S. , Lovisari L. , Riva G. , Rossetti M. 
Published: January 2025

Context. X-ray observations of galaxy clusters are routinely used to derive radial distributions of intracluster medium (ICM) thermodynamical properties, such as density and temperature. However, observations only allow access to quantities projected on the celestial sphere, so an assumption on the three-dimensional distribution of the ICM is necessary. Usually, spherical geometry is assumed.
Aims. The aim of this paper is to determine the bias due to this approximation on the reconstruction of the ICM density radial profile of a cluster sample and on the intrinsic scatter of the density profiles’ distribution, particularly when the substructures of clusters are not masked.
Methods. We used simulated clusters for which we can access the three-dimensional ICM distribution. In particular, we considered a sample of 98 simulated clusters drawn from THE THREE HUNDRED project. For each cluster, we simulated 40 different observations by projecting the cluster along 40 different lines of sight. We extracted the ICM density profile from each observation, assuming the ICM to be spherically distributed. For each line of sight, we then considered the mean density profile over the sample and compared it with the three-dimensional density profile given by the simulations. We thus derived the spherical bias in the density profile by considering the ratio between the observed and the input quantities. We also studied the bias in the intrinsic scatter of the density profile distribution by performing the same procedure.
Results. We find a bias in the density profile, bn, smaller than 10% for R ≲ R500, and it increases up to ≈50% for larger radii. The bias in the intrinsic scatter profile, bs, is higher, reaching a value of ≈100% for R ≈ R500. We find that the bias for both of the analyzed quantities strongly depends on the morphology composition of the objects in the sample. For clusters that do not show large-scale substructures, both bn and bs are reduced by a factor of two. Conversely, for systems that do show large-scale substructures, both bn and bs increase significantly.
Correlation between Humpback Deformity and Presence or Absence of Avascular Necrosis and Nonunion in Patients with Scaphoid Waist Fractures
Authors: Abidi Syed , Shepel Michael , Sauder David , Mondal Prosanta , Obaid Haron 
Published: January 2025

Abstract
Background Scaphoid fractures often lead to nonunion and avascular necrosis (AVN). This study investigates the association between humpback deformity (volar angulation malalignment in scaphoid waist fractures) and these complications.
Materials and Methods A retrospective review of radiographs/computed tomography scans from patients with acute scaphoid waist fractures was performed. Union/nonunion status and AVN presence or absence were evaluated based on follow-up radiographs. Humpback deformity was identified using a height-to-length ratio (H/L) > 0.65. Images were assessed by consensus by two musculoskeletal radiologists. Statistical analysis included chi-square/Fisher's exact tests, t-tests, and logistic regression.
Results A total of 84 patients (mean age: 30.4 years) with a mean follow-up for 447.7 days were included. Nonunion occurred in 31%, AVN in 9.5%, and humpback deformity in 54.8%. The nonunion cohort (26 patients) had a higher prevalence of humpback deformity (45.7%). In the AVN cohort (8 patients), 15.2% had a humpback deformity. The humpback cohort (54 patients) showed 46.3% nonunion and 15.2% AVN. Significant association was found between humpback deformity and nonunion (p = 0.001), but not between humpback deformity and AVN (p = 0.067). Logistic regression indicated humpback deformity as a significant predictor of nonunion (p = 0.002).
Conclusion The study revealed a significant association between humpback deformity and nonunion in scaphoid fractures. Although no significant association was found between humpback deformity and AVN, the AVN cohort showed a trend toward higher rates of humpback deformity suggesting that humpback deformity may occur in the context of scaphoid AVN.
Light-Induced Metal-Free Catalyzed C–H Alkylation of (Iso)Quinolines
Authors: Weng Jianquan , Zhang Guofu , Wang Qing , Mei Guangyao , Luo Zi Jin , Sun Xiaotong 
Published: January 2025

AbstractA new method for preparing alkylated (iso)quinolines with substituted (iso)quinolines and alkanes as substrates, PIFA as an oxidant, and Rose bengal as a photosensitizer under 50 W light irradiation is proposed. Diverse structures were shown to be tolerated under optimal conditions, and a series of alkylated products were obtained in the desired yields. Compared with previous reactions using aldehydes and carboxylic acids as carbon sources, this method uses simple alkanes as carbon sources, offering good chemical stability and high atom economy.
Does Artificial Intelligence (AI) enhance green economy efficiency? The role of green finance, trade openness, and R&D investment
Authors: Wang Qiang , Sun Tingting , Li Rongrong 
Published: January 2025

AbstractMarine fisheries constitute a crucial component of global green development, where artificial intelligence (AI) plays an essential role in enhancing green economic efficiency associated with marine fisheries. This study utilizes panel data from 11 coastal provinces and municipalities in China from 2009 to 2020, employing the entropy method and the super-efficiency EBM model to calculate the AI index and the green economic efficiency of marine fisheries. Based on these calculations, we utilize fixed effects models, moderation effect models, and panel threshold models to examine the impact of AI on the green economic efficiency of marine fisheries. The study reveals that: (i) From 2009 to 2020, AI has significantly improved overall, while the green economic efficiency of marine fisheries has shown a fluctuating trend, with substantial regional disparities. (ii) AI significantly enhances the green economic efficiency of marine fisheries. (iii) Green finance, trade openness, and R&D investment act as crucial moderating variables, accelerating AI development and further improving the green economic efficiency of marine fisheries. (iv) The impact of AI on green economic efficiency varies across different intervals of green finance, trade openness, and R&D investment. These findings are crucial for understanding and advancing the informatization strategy of marine fisheries and hold significant implications for the sustainable development of global marine fisheries.
Ultrawide bandgap semiconductor h-BN for direct detection of fast neutrons
Authors: Li J. , Tingsuwatit A. , Alemoush Z. , Lin J. Y. , Jiang H. X. 
Published: January 2025

III-nitride wide bandgap semiconductors have contributed on the grandest scale to many technological advances in lighting, displays, and power electronics. Among III-nitrides, BN has another unique application as a solid-state neutron detector material because the isotope B-10 is among a few elements that have an unusually large interaction cross section with thermal neutrons. A record high thermal neutron detection efficiency of 60% has been achieved by B-10 enriched h-BN detectors of 100 μm in thickness in our group. However, direct detection of fast neutrons with energies above 1 MeV is highly challenging due to the extremely low interaction cross section of fast neutrons with matter. We report the successful attainment of 0.4 mm thick freestanding h-BN 4″-diameter wafers, which enabled the demonstration of h-BN fast neutron detectors capable of delivering a detection efficiency of 2.2% in response to a bare AmBe neutron source. Furthermore, it was shown that the energy information of incoming fast neutrons is retained in the neutron pulse-height spectra. A comparison of characteristics between h-BN fast and thermal neutron detectors is summarized. Neutron detectors are vital diagnostic instruments for nuclear and fusion reactor power and safety monitoring, oil field exploration, neutron imaging and therapy, as well as for plasma and material science research. With the outstanding attributes resulting from its ultrawide bandgap (UWBG), including the ability to operate at extreme conditions of high power, voltage, and temperature, the availability of h-BN UWBG semiconductor detectors with the capability of simultaneously detecting thermal and fast neutrons with high efficiencies is expected to open unprecedented applications that are not possible to attain by any other types of neutron detectors.
Maple leaf-based triboelectric nanogenerator for efficient energy harvesting and precision monitoring in ping-pong training
Authors: Yu He , Li Zheng 
Published: January 2025

Triboelectric technology, with its renewable, low-cost, and eco-friendly advantages, offers new possibilities for intelligent motion-sensing equipment and sports monitoring. We propose a maple leaf-based triboelectric nanogenerator (ML-TENG) for green mechanical energy harvesting and detecting table tennis corner kicks. The ML-TENG operates in contact-separation mode and achieves a peak power output of 63.38 W/m3 at an optimal load of 50 MΩ. The experimental results show a transfer charge (Qsc) of 35 nC, a short-circuit current (Isc) of 9 μA, and an open-circuit voltage (Voc) of 50 V. Tested with a ping-pong paddle, the ML-TENG generates consistent voltage even under high-frequency impacts, demonstrating its sensitivity to both strong and weak forces. This ready-to-use design requires minimal preparation, highlighting triboelectric technology’s potential for improving sports monitoring accuracy and enabling real-time athletic performance analysis.
Effects of intra-tumoral cellular heterogeneity of oxygen partial pressure on biological effectiveness of hydrogen-, helium-, carbon-, oxygen-, and neon-ion beams
Authors: Inaniwa Taku , Masuda Takamitsu , Kanematsu Nobuyuki 
Published: January 2025

Abstract

Objective. The tumor microenvironment characterized by heterogeneously organized vasculatures causes intra-tumoral heterogeneity of oxygen partial pressure

p

at the cellular level, which cannot be measured by current imaging techniques. The intra-tumoral cellular

p

heterogeneity may lead to a reduction of therapeutic effects of radiation. The purpose of this study was to investigate the effects of the heterogeneity on biological effectiveness of H-, He-, C-, O-, and Ne-ion beams for different oxygenation levels, prescribed dose levels, and cell types. Approach. The intra-tumoral cellular

p

distributions were simulated with a numerical tumor model for average oxygen pressures

p
¯

t

ranging from 2.5 to 15 mmHg. The relative biological effectiveness (RBE)-weighted dose distributions of 3–15 Gy prescribed doses were planned for a cuboid target with the five ion species for constant

p
¯

t

values. Radiosensitivities of human salivary gland tumor (HSG) and Chinese hamster ovary (CHO) cells were investigated. The planned dose distributions were then recalculated by taking the

p

heterogeneity into account. Main results. As

p
¯

t

decreased and prescribed dose increased, the biological effectiveness of the ion beams decreased due to the

p

heterogeneity. The reduction in biological effectiveness was pronounced for lighter H- and He-ion beams compared to heavier C-, O-, and Ne-ion beams. The RBE-weighted dose in the target for HSG (CHO) cells decreased by 41.2% (44.3%) for the H-ion beam, while it decreased by 16.7% (14.7%) for the Ne-ion beam at a prescribed dose of 15 Gy under a

p
¯

t

of 2.5 mmHg. Significance. The intra-tumoral cellular

p

heterogeneity causes a significant reduction in biological effectiveness of ion beams. These effects should be considered in estimation of therapeutic outcomes.
Defect related vortex dynamics behaviors in ‘1144’-type iron-based superconductors
Authors: Li Yigang , Liu Cong , Chen Dong , Yi Xiaolei , Wang Lubin , Tang Qingbin , Li Fangtao , Wang Chunlei , Yu Benhai , Ma Yanwei 
Published: January 2025

Abstract
We have synthesized ‘1144’- type (Ca1–x
Pr
x
KFe4As4 and CaKFe4As4) and ‘122’-type (Ba0.6K0.4Fe2As2 and Ba0.6Rb0.4Fe2As2) iron-based superconductors. Based on these crystals, we have investigated the vortex dynamics of the ‘1144’- and ‘122’-type iron-based superconductors. The results indicate that the novel flux dynamics behaviors of the ‘1144’-type iron-based superconductors are closely related to their defect structures. First, the intergrowths in ‘1144’-type superconductors can function as columnar defects under an applied magnetic field H∥ab-plane, which results in a dip structure in the magnetization hysteresis loops (MHLs) near zero field due to the self-field effect. Second, the intergrowths, as strong pinning sites, provide a large pulling force on the flux lines and cause a small magnetization peak at temperatures below 10 K under magnetic fields from about 3–7 T in MHLs for the ‘1144’-type superconductors. Third, there may be vortex entanglement due to the presence of strong pinning centers, which impedes the elastic-to-plastic motion of vortices (E–P phase transition) resulting in a weak second magnetization peak (SMP) effect in the bulk ‘1144’-type superconductors. Fourth, the intergrowths introduce disorder into the superconductors and accelerate the magnetic 3D-to-2D transition, which causes the thickness-dependent J
c and SMP effects due to the rigidity of flux lines with decreasing sample thickness. The current results are significant for our understanding of the relationship between the flux pinning behaviors and the defect structures for a superconductor.
Breakdown conditions of a multi-electrode low temperature atmospheric pressure plasma source
Authors: Gillies R M , Tompkins J , McKay K 
Published: January 2025

Abstract
Low-temperature atmospheric pressure plasma jets are generally small in scale (∼few mm) and often require high-breakdown voltages and high value gases to operate. This study investigates the advantageous properties of a novel multi-electrode jet-like source with separately powered (180° phase-shifted) live electrodes, namely significantly reduced breakdown voltage, increased operating voltage range and higher gas admixture capabilities. Gas breakdown voltage trends are demonstrated across multiple physical parameters, including tube diameter, electrode spacing and frequency. The potential uses of a safer, more practical discharge system are highlighted, as well as the conditions across the 3 kHz–30 kHz range under which plasma parameters are varied. An electrical analysis was also performed to provide a better understanding of the plasma characteristics beyond that of gas breakdown, specifically that of potential mode transitions that have not been taken into account in prior works.
Continuous-variable quantum secure direct communication based on N-APSK with Boltzmann-Maxwell distribution
Authors: Cao Zheng-Wen , Zhang Yu-Jie , Chai Geng , Liang Zhang-Tao , Chen Xin-Lei , Wang Lei , Wang Yu-Jie 
Published: January 2025

Abstract
Continuous-variable quantum secure direct communication (CVQSDC) with Gaussian-modulation (GM) demands a considerable quantity of random numbers during the preparation process and encodes them separately on the quadrature components of the quantum states. Hence, high-speed random number generators are required to satisfy the demand, which is difficult to implement in practical applications. CVQSDC with discrete-modulation (DM), correspondingly, employs a finite number of quantum states for achieving encoding, which can circumvent the shortcomings existing in the GM scheme. Based on the advantages of DM, the issue of attaining the most optimal secrecy capacity and communication distance remains to be resolved. Here, we propose a CVQSDC protocol based on N-symbol amplitude phase shift keying (N-APSK), which exploits the Boltzmann-Maxwell distribution assisted probability shaping technique. In comparison with the uniform distribution, according to 32-APSK CVQSD, the proposed scheme extends the communication distance by about 38%, while obtaining higher secrecy capacity at the same communication distance. Furthermore, increasing the value of N will concurrently increase the quantity of rings in the constellation, thereby facilitating enhancements in communication distance. This work incorporates the modulation approaches prevalently employed in classical communication into the realm of quantum communication, attaining gratifying advancements in communication distance and secrecy capacity, and concurrently facilitating the integrated development of quantum communication and classical communication.
Effect of spherical Mo metal particles on microstructure and properties of 316L stainless steel during laser powder bed fusion
Authors: Zhang Hao , Yang Lijun , Zhang Zhenmeng , Chen Zhihao , Song Ziliang , Wang Chenyang , Wu Xihui , Zhu Xiebin 
Published: January 2025

Abstract
Aiming at the performance defects of 316L stainless steel (316LSS), such as low surface hardness, low strength, and poor resistance to chloride ion pitting, Mo/316L particle-reinforced metal matrix composites (PRMMCs) were prepared in this paper using the laser powder-bed fusion (L-PBF) process. It was found that the addition of Mo particles significantly affected the solidification behavior and organization of the matrix and formed a unique spherical metal reinforcement in the matrix, which significantly enhanced the strength of the material while avoiding a serious loss of plasticity: compared with PBF-316L, the ultimate tensile strength (UTS) and elongation of 2Mo/316L with 2 wt% Mo particles added were simultaneously increased by 9.7% and 10.4%, which is a good result of improving strength and plasticity at the same time. With the addition of 6 wt% Mo particles, the UTS of 6Mo/316L reaches 952 MPa while still maintaining a good elongation of 21%. In addition, the hardness, wear resistance and corrosion resistance of the Mo/316L material were significantly improved to varying degrees. This overall improvement in the performance defects of 316LSS is difficult to achieve with other types of reinforcing particles, demonstrating the potential application of using such spherical refractory metal particles for the preparation of PRMMCs in the L-PBF process.
A practical case study on effect of moisture ingress in power cables and methods to reduce equipment failure
Authors: Gugulothu Babu Naik , Lakshminarayanan Sanjay , Palati Madhu , Haleyur Lakshmegowda Suresh , Bukya Mahipal 
Published: January 2025

Abstract
Over the past few years, there has been a rise in the quantity of underground cables used in power transmission and distribution networks in many urban areas worldwide. Technological and economic considerations, along with space constraints, are responsible for this increase. As the number of cables increases, utilities face challenges in effectively maintaining and testing their condition. Particularly, the maintenance of medium-voltage cables, such as three-core 33 kV cables, is becoming increasingly challenging. One of the biggest problems with medium-voltage cables is their preference when the load is closer to the substation. Because the cables are closer to the source, the probability of the end termination kit failing is higher, leading to short-line faults (SLF). Short-line faults subject the connected switchgear and transformers to severe electrical, thermal, and mechanical stresses. Cable faults can cause equipment failure, resulting in external flashovers, which in turn raise the temperature and ultimately lead to insulator failure. Low external temperatures can increase moisture content in the environment, leading to equipment failure. This paper investigates switchgear failures in 132/33 KV substations caused by cable faults and ambient temperature and presents methods to mitigate switchgear and instrument transformer failures caused by cable faults. Over time, the proposed methods have led to a decrease in the number of failures. In recent years, protocols such as IEC61850, MODBUS, IEC60870-4, and others have transformed conventional substations into automated substations. We propose a low-cost, practically feasible solution using the GOOSE technique in the IEC61850 protocol to prevent the flashover of the circuit breakers, following a detailed investigation.