bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling Musical Production: Strauss, Mahler and Commodity Fetishism in the Late Nineteenth Century
Authors: Gentry Jonathan 
Published: November 2021

This article locates social relationships within late-nineteenth-century German orchestral music by examining orchestration practices and aesthetics. Wagner's innovations in tone colour, Liszt's use of programmes, and Hanslick's formalism all took attention away from orchestra performers and forged a more direct relationship between audience and composer. This article argues that commercial exchange of serious music displaced social relationships between composer, performer and audience into aesthetic dictums. In particular, the widely agreed upon subordination of orchestration and colour to compositional ‘content’ was a manifestation of the social subordination of performers to composers and resulted in the decreased visibility of performers to consumers.In ultimately breaking from both New German and formalist conventions, Strauss's Don Juan and Mahler's First Symphony brought unwanted attention to orchestration and a renewed focus on performance and performers. In contrast to Wagner's use of doublings, which created timbres without clear instrumental provenance, the orchestration choices of Strauss and Mahler emphasize distinctions between instruments and themes, further highlighting the virtuosic demands they place on performers. Strauss and Mahler made performers into co-producers of their music and raised orchestral colour to the status of content. By employing Marx's concept of commodity fetishism, which Adorno himself largely obscures, this article goes beyond Adorno's and Dahlhaus's analysis of the ‘emancipation of colour’ to show how concert consumption objectified social relations and hierarchies as issues of mere aesthetic form, while compositions themselves became imbued with life-like subjectivity.
Impact of Decelerating India‐Asia Convergence on the Crustal Flow Kinematics in Tibet: An Insight From Scaled Laboratory Modeling
Authors: Maiti Giridas , Roy Arnab , Sen Joyjeet , Mandal Nibir 
Published: November 2021

AbstractThe factors controlling the spatiotemporally varying deformation patterns in Tibet, a prolonged period (∼50 to 19 ± 3 Ma) of NNE‐SSW shortening, accompanied by eastward flow and orogen‐parallel extension in a later stage (19 ± 3 Ma to present‐day), are still poorly constrained. Using viscous models, we performed scaled laboratory experiments with steady and unsteady state collision kinematics to address this issue. Our model Tibet under steady‐state collision, irrespective of high (5.5 cm/yr) or low (3.5 cm/yr) indentation rates fails to produce the present‐day crustal velocity fields and the deformation patterns, reported from GPS observations. An unsteady‐state collision with decelerating convergence rates (5.5–3.5 cm/yr) is found to be a necessary condition for the initiation of eastward flow and ESE‐WNW extensional deformations. The model results also suggest that the mechanical resistance offered by the rigid Tarim block resulted in crustal uplift at faster rates in western Tibet, setting a west to east topographic gradient, existing till present‐day. This topographic gradient eventually polarized the gravity‐controlled flow in the east direction when the convergence velocity decelerated to ∼3.5 cm/yr at around 19 ± 3 Ma. Our model shows the present‐day eastward flow in central Tibet follows nearly a Poiseuille type velocity profile, bounded by the Himalaya in the south and the Tarim basin in northern Tibet. This flow kinematics allows us to explain the preferential locations of crustal‐scale dextral and sinistral faults in southern and northern Tibet, respectively. Finally, the present‐day model crustal‐flow velocity, strain‐rates, and topographic variations are validated with GPS and geological field data.
Comparison of a Neutral Density Model With the SET HASDM Density Database
Authors: Weimer Daniel R. , Tobiska W. Kent , Mehta Piyush M. , Licata R. J. , Drob Douglas P. , Yoshii Jean 
Published: November 2021

AbstractThe EXospheric TEMperatures on a PoLyhedrAl gRid (EXTEMPLAR) method predicts the neutral densities in the thermosphere. The performance of this model has been evaluated through a comparison with the Air Force High Accuracy Satellite Drag Model (HASDM). The Space Environment Technologies (SET) HASDM database that was used for this test spans the 20 years 2000 through 2019, containing densities at 3 hr time intervals at 25 km altitude steps, and a spatial resolution of 10° latitude by 15° longitude. The upgraded EXTEMPLAR that was tested uses the newer Naval Research Laboratory MSIS 2.0 model to convert global exospheric temperature values to neutral density as a function of altitude. The revision also incorporated time delays that varied as a function of location, between the total Poynting flux in the polar regions and the exospheric temperature response. The density values from both models were integrated on spherical shells at altitudes ranging from 200 to 800 km. These sums were compared as a function of time. The results show an excellent agreement at temporal scales ranging from hours to years. The EXTEMPLAR model performs best at altitudes of 400 km and above, where geomagnetic storms produce the largest relative changes in neutral density. In addition to providing an effective method to compare models that have very different spatial resolutions, the use of density totals at various altitudes presents a useful illustration of how the thermosphere behaves at different altitudes, on time scales ranging from hours to complete solar cycles.
Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
Authors: Zhou Kuangguo , Zhou Mi , Cheng Ling , Chen Xing , Wang Xiaomin , Chu Yajing , Yu Qilin , Zhang Shu , Wang Na , Zhao Lei , Wang Di , Huang Liang , Wang Congyi , Yuan Weiping , Zhou Jianfeng 
Published: November 2021

AbstractAcute myeloid leukemia (AML) is a deadly cancer characterized by an expanded self-renewal capacity that is associated with the accumulation of immature myeloid cells. Emerging evidence shows that methyl-CpG-binding domain protein 2 (MBD2), a DNA methylation reader, often participates in the transcriptional silencing of hypermethylated genes in cancer cells. Nevertheless, the role of MBD2 in AML remains unclear. Herein, by using an MLL-AF9 murine model and a human AML cell line, we observed that loss of MBD2 could delay the initiation and progression of leukemia. MBD2 depletion significantly reduced the leukemia burden by decreasing the proportion of leukemic stem cells (LSCs) and inhibiting leukemia cell proliferation in serial transplantation experiments, thereby allowing leukemic blasts to transition to a more mature state reflecting normal myelopoiesis. Both gene expression analyses and bioinformatic studies revealed that MBD2 negatively modulated genes related to myeloid differentiation, and was necessary to sustain the MLL-AF9 oncogene-induced gene program. We further demonstrated that MBD2 could promote LSC cell cycle progression through epigenetic regulation of CDKN1C transcription probably by binding to its promoter region. Taken together, our data suggest that MBD2 promotes AML development and could be a therapeutic target for myeloid malignancies.
Plasma concentrations of branched-chain amino acids differ with Holstein genetic strain in pasture-based dairy systems
Authors: Jorge-Smeding Ezequiel , Carriquiry Mariana , Cantalapiedra-Hijar Gonzalo , Mendoza Alejandro , Astessiano Ana Laura 
Published: November 2021

AbstractIn pasture-based systems, there are nutritional and climatic challenges exacerbated across lactation; thus, dairy cows require an enhanced adaptive capacity compared with cows in confined systems. We aimed to evaluate the effect of lactation stage (21 vs. 180 days in milk,DIM) and Holstein genetic strain (North American Holstein,NAH, n = 8; New Zealand Holstein,NZH, n = 8) on metabolic adaptations of grazing dairy cows through plasma metabolomic profiling and its association with classical metabolites. Although 67 metabolites were affected (FDR< 0.05) by DIM, no metabolite was observed to differ between genetic strains while only alanine was affected (FDR= 0.02) by the interaction between genetic strain and DIM. However, complementary tools for time-series analysis (ASCA analysis, MEBA ranking) indicated that alanine and the branched-chain amino acids (BCAA) differed between genetic strains in a lactation-stage dependent manner. Indeed, NZH cows had lower (P-Tukey < 0.05) plasma concentrations of leucine, isoleucine and valine than NAH cows at 21 DIM, probably signaling for greater insulin sensitivity. Metabolic pathway analysis also revealed that, independently of genetic strains, AA metabolism might be structurally involved in homeorhetic changes as 40% (19/46) of metabolic pathways differentially expressed (FDR< 0.05) between 21 and 180 DIM belonged to AA metabolism.
Development of computer-controlled atmospheric pressure plasma structuring for 2D/3D pattern on fused silica
Authors: Li Duo , Ji Peng , Xu Yang , Wang Bo , Qiao Zheng , Ding Fei 
Published: November 2021

AbstractFused silica with structured and continuous patterns is increasingly demanded in advanced imaging and illumination fields because of its excellent properties and functional performance. Atmospheric pressure plasma, based on pure chemical etching under atmospheric pressure, is developed as a promising fabrication technique for fused silica due to its deterministic high material removal rate, controllable removal imprint and no mechanical load. The stable and controllable Gaussian-shape removal function makes computer-controlled plasma tool potential to generate complex structures with high accuracy, efficiency and flexibility. In the paper, computer-controlled atmospheric pressure plasma structuring (APPS) is proposed to fabricate 2D/3D patterns on fused silica optics. The capacitively coupled APPS system with a double-layer plasma torch and its discharge characteristics are firstly developed. By means of multi-physics simulation and process investigation, the stable and controllable Gaussian-shape removal function can be achieved. Two different structuring modes, including discrete and continuous APPS, are explored for 2D/3D patterns. A series of structuring experiments show that different kinds of 2D patterns (including square lens array, hexagon lens array and groove array) as well as complex 3D phase plate patterns have been successfully fabricated, which validates the effectiveness of the proposed APPS of 2D/3D patterns on fused silica optics.
Increment in the volcanic unrest and number of eruptions after the 2012 large earthquakes sequence in Central America
Authors: González Gino , Fujita Eisuke , Shibazaki Bunichiro , Hayashida Takumi , Chiodini Giovanni , Lucchi Federico , Yokoyama Izumi , Nemeth Karoly , Mora-Amador Raúl , Moya Aaron , Chigna Gustavo , Martí Joan , Rouwet Dmitri 
Published: November 2021

AbstractUnderstanding the relationship cause/effect between tectonic earthquakes and volcanic eruptions is a striking topic in Earth Sciences. Volcanoes erupt with variable reaction times as a consequence of the impact of seismic waves (i.e. dynamic stress) and changes in the stress field (i.e. static stress). In 2012, three large (Mw ≥ 7.3) subduction earthquakes struck Central America within a period of 10 weeks; subsequently, some volcanoes in the region erupted a few days after, while others took months or even years to erupt. Here, we show that these three earthquakes contributed to the increase in the number of volcanic eruptions during the 7 years that followed these seismic events. We found that only those volcanoes that were already in a critical state of unrest eventually erupted, which indicates that the earthquakes only prompted the eruptions. Therefore, we recommend the permanent monitoring of active volcanoes to reveal which are more susceptible to culminate into eruption in the aftermath of the next large-magnitude earthquake hits a region.
Conformation and membrane interaction studies of the potent antimicrobial and anticancer peptide palustrin-Ca
Authors: Timmons Patrick B. , Hewage Chandralal M. 
Published: November 2021

AbstractPalustrin-Ca (GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP) is a host defence peptide with potent antimicrobial and anticancer activities, first isolated from the skin of the American bullfrogLithobates catesbeianus. The peptide is 31 amino acid residues long, cationic and amphipathic. Two-dimensional NMR spectroscopy was employed to characterise its three-dimensional structure in a 50/50% water/2,2,2-trifluoroethanol-$$d_{3}$$d3mixture. The structure is defined by an$$\alpha$$α-helix that spans between Ile$$^{6}$$6-Ala$$^{26}$$26, and a cyclic disulfide-bridged domain at the C-terminal end of the peptide sequence, between residues 23 and 29. A molecular dynamics simulation was employed to model the peptide’s interactions with sodium dodecyl sulfate micelles, a widely used bacterial membrane-mimicking environment. Throughout the simulation, the peptide was found to maintain its$$\alpha$$α-helical conformation between residues Ile$$^{6}$$6-Ala$$^{26}$$26, while adopting a position parallel to the surface to micelle, which is energetically-favourable due to many hydrophobic and electrostatic contacts with the micelle.
Field metabolic rates of giant pandas reveal energetic adaptations
Authors: Bi Wenlei , Hou Rong , Owens Jacob R. , Spotila James R. , Valitutto Marc , Yin Guan , Paladino Frank V. , Wu Fanqi , Qi Dunwu , Zhang Zhihe 
Published: November 2021

AbstractKnowledge of energy expenditure informs conservation managers for long term plans for endangered species health and habitat suitability. We measured field metabolic rate (FMR) of free-roaming giant pandas in large enclosures in a nature reserve using the doubly labeled water method. Giant pandas in zoo like enclosures had a similar FMR (14,182 kJ/day) to giant pandas in larger field enclosures (13,280 kJ/day). In winter, giant pandas raised their metabolic rates when living at − 2.4 °C (36,108 kJ/day) indicating that they were below their thermal neutral zone. The lower critical temperature for thermoregulation was about 8.0 °C and the upper critical temperature was about 28 °C. Giant panda FMRs were somewhat lower than active metabolic rates of sloth bears, lower than FMRs of grizzly bears and polar bears and 69 and 81% of predicted values based on a regression of FMR versus body mass of mammals. That is probably due to their lower levels of activity since other bears actively forage for food over a larger home range and pandas often sit in a patch of bamboo and eat bamboo for hours at a time. The low metabolic rates of giant pandas in summer, their inability to acquire fat stores to hibernate in winter, and their ability to raise their metabolic rate to thermoregulate in winter are energetic adaptations related to eating a diet composed almost exclusively of bamboo. Differences in FMR of giant pandas between our study and previous studies (one similar and one lower) appear to be due to differences in activity of the giant pandas in those studies.
Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
Authors: Park Soojin , Lee Dal Nim , Jin Young Woo , Cha Eun Shil , Jang Won-Il , Park Sunhoo , Seo Songwon 
Published: November 2021

AbstractRadiation-induced cancer risks have known stochastic effects; however, regarding non-cancer diseases, evidence of risk at low radiation doses remains unclear. We aimed to identify underlying characteristics concerning non-cancer disease prevalence and determine associations with radiation dose among Korean radiation workers. Using a nationwide baseline survey, 20,608 workers were enrolled. Data concerning participant demographics, occupational characteristics, lifestyle, and lifetime prevalence of non-cancer diseases were linked to a national dose registry. We compared non-cancer disease prevalences in the Korean general population with those in this cohort and undertook a dose–response analysis concerning the cumulative dose. Hyperlipidemia (10.6%), circulatory (9.6%), and respiratory (4.1%) system diseases, followed by thyroid diseases (3.5%), had the highest prevalences, with hyperlipidemia, thyroid diseases, and hepatitis prevalence being higher in the cohort than in the general population. Radiation doses were associated with elevated prevalences of most diseases; however, associations were attenuated and not significant after adjusting for confounders, except for musculoskeletal system diseases (prevalence odds ratio [POR]/10 mSv, 1.03; 95% confidence interval [CI] 1.00–1.07) and cataracts (POR/10 mSv, 1.04; 95% CI 1.00–1.07). Further studies are warranted to investigate the causality of those non-cancer diseases involving more varied confounders such as physical and psychosocial stresses and ultraviolet light.
Non-equilibrium phase transition at a critical point of human blood
Authors: Pietruszka Mariusz A. 
Published: November 2021

AbstractBlood is the basic medium in the existence, evolution and physiological balance of animals and represents the biochemical “Internet” of the body; at least human blood exhibit the presence of an emergent phase that is highly unusual. Homeostasis, the state of the optimal functioning of the body, is maintained in living organisms by many chemical and physical conditions, particularly temperature. However, no regulatory mechanism has been identified that has led to a predetermined (molecularly encoded) optimal, individually variable, very specific temperature of around 36 °C. Additionally, the homeostatic temperature range, which is kept within predetermined limits, is merely an empirical fact. In the following, I will show that thereference temperaturethat is necessary to achieve homeostasis can be established, and a presethomeostatic rangecan be determined, using an original experimental method and refined tools of mathematical physics related to the nonlinear measures of the complexity of human blood. Moreover, signatures of a macroscopic coherent state in a non-equilibrium system at a critical temperature are obtained.
Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
Authors: Elam Kit K. , Ha Thao , Neale Zoe , Aliev Fazil , Dick Danielle , Lemery-Chalfant Kathryn 
Published: November 2021

AbstractGenetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of genetic variants identified from EA samples in other racial/ethnic populations, leading to inconclusive findings about genetic effects on alcohol use. The current study examined how genetic influences on alcohol use varied by age across a 15 year period within a diverse ethnic/racial sample of adolescents. Using a multi-ethnic approach, polygenic risk scores were created for African American (AA, n = 192) and EA samples (n = 271) based on racially/ethnically aligned genome wide association studies. Age-varying associations between polygenic scores and alcohol use were examined from age 16 to 30 using time-varying effect models separately for AA and EA samples. Polygenic risk for alcohol use was found to be associated with alcohol use from age 22–27 in the AA sample and from age 24.50 to 29 in the EA sample. Results are discussed relative to the intersection of alcohol use and developmental genetic effects in diverse populations.
Shallow-emerged coral may warn of deep-sea coral response to thermal stress
Authors: Johnstone Julia W. , Waller Rhian G. , Stone Robert P. 
Published: November 2021

AbstractIn the Gulf of Alaska, commercially harvested fish species utilize habitats dominated by red tree corals (Primnoa pacifica) for shelter, feeding, and nurseries, but recent studies hint that environmental conditions may be interrupting the reproductive lifecycle of the corals. The North Pacific has experienced persistent and extreme thermal variability in recent years and this pattern is predicted to continue in coming decades. Recent discovery of deep-water emerged coral populations in Southeast Alaska fjords provided opportunity for detailed life-history studies and comparison to corals in managed habitats on the continental shelf. Here we show that sperm from deep colonies develops completely, but in shallow colonies, sperm development is prematurely halted, likely preventing successful production of larvae. We hypothesize that the divergence is due to differing temperature regimes presently experienced by the corals. Compared to deep populations below the thermocline, shallow populations experience much greater seasonal thermal variability and annual pulses of suspected near-lethal temperatures that appear to interrupt the production of viable gametes. The unique opportunity to comprehensively study emerged populations presently affected by thermal stress provides advance warning of the possible fate of deep corals in the Gulf of Alaska that will soon experience similar ocean conditions.
Tandem Mass Tag labelling quantitative acetylome analysis of differentially modified proteins during mycoparasitism of Clonostachys chloroleuca 67–1
Authors: Jiang Na , Lv Binna , Wu Haixia , Li Shidong , Sun Manhong 
Published: November 2021

AbstractLysine acetylation (Kac) is an important post-translational modification (PTM) of proteins in all organisms, but its functions have not been extensively explored in filamentous fungi. In this study, a Tandem Mass Tag (TMT) labelling lysine acetylome was constructed, and differentially modified Kac proteins were quantified during mycoparasitism and vegetative growth in the biocontrol fungus Clonostachys chloroleuca 67–1, using liquid chromatography-tandem mass spectrometry (LC–MS/MS). A total of 1448 Kac sites were detected on 740 Kac proteins, among which 126 sites on 103 proteins were differentially regulated. Systematic bioinformatics analyses indicate that the modified Kac proteins were from multiple subcellular localizations and involved in diverse functions including chromatin assembly, glycometabolism and redox activities. All Kac sites were characterized by 10 motifs, including the novel CxxKac motif. The results suggest that Kac proteins may have effects of broadly regulating protein interaction networks during C. chloroleuca parasitism to Sclerotinia sclerotiorum sclerotia. This is the first report of a correlation between Kac events and the biocontrol activity of C. chloroleuca. Our findings provide insight into the molecular mechanisms underlying C. chloroleuca control of plant fungal pathogens regulated by Kac proteins.
Missions du futur et nouveaux concepts en propulsion plasma
Authors: Garrigues Laurent , Gaboriau Freddy , Guglielmi Alexandre , Boeuf Jean-Pierre 
Published: November 2021

L’intérêt d’utiliser des particules chargées accélérées à de grandes vitesses pour propulser un engin spatial a germé dans la tête de C. Tsiolkovski (1857-1935), qui a posé les fondements de l’astronautique dans son ouvrage de 1903. Il a fallu néanmoins attendre la course à l’espace durant la guerre froide pour voir émerger les premiers concepts de propulseurs à plasma, puis leur utilisation sur les satellites et les premières sondes d’exploration à la fin du XXe siècle.
Le XXIe siècle ouvre la voie à de nouveaux concepts pour des plateformes de satellites toujours plus massives, des sondes d’exploration envoyées toujours plus loin, ou des vols habités pour l’exploration de la planète Mars.