bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of GSTT1 and GSTP1 polymorphisms on type 2 diabetes mellitus and diabetic retinopathy risk in the Chinese population: a case control study
Authors: Geng Xinqian , Zha Ling , Xiong Yuxin , Xu Fan , Xu Bo , Wang Feiying , Wang Xiaoling , Yang Ke , Tao Wenyu , Li Yiping , Zhou Taicheng , Yang Ying 
Published: February 2021

Abstract
Background: Studies have revealed the association of glutathione S-transferases (GSTM1 and GSTT1) deletion (null) polymorphism with the risks of developing type 2 diabetes mellitus (T2DM) and its complications. The present study aimed to investigate the relationship between GSTT1/ GSTP1 gene polymorphisms and the risks of T2DM and diabetic retinopathy (DR) in a Chinese population.Methods: In this case-control study, a total of 336 subjects with T2DM and a defined ophthalmologic status were recruited from the Second People’s Hospital of Yunnan Province between June 2014 and October 2016. Seventy-two age-matched healthy controls were also enrolled. Physical examinations and laboratory tests were performed. The frequencies of GSTT1 genotypes in all participants were determined by polymerase chain reaction (PCR) followed by agarose gel electrophoresis. Genotyping of GSTP1 gene was identified by PCR amplification followed by sequencing.Results: Compared with healthy controls, the GSTT1-null genotype was significantly more common in diabetic patients with or without DR (all P < 0.05). However, there was no difference in the frequencies of the GSTP1 genotype (AA, GA, GG) between diabetic patients with or without DR and healthy controls. Furthermore, neither the GSTP1 nor GSTT1 genetic polymorphism was associated with the development of DR. In the present study, the risk of developing T2DM was significantly higher in subjects carrying the combined heterozygous GSTP1 (AG) and null GSTT1 genotypes (OR = 0.40, 95% CI = 0.21-0.74, P = 0.02).Conclusions: The deletion of the GSTT1 genotype was associated with a higher risk of developing T2DM, whether alone or in combination with GSTP1, indicating that the null genotype of GSTT1 may serve as a potential biomarker for T2DM in the Chinese population, which is helpful for clinicians to make more effective risk-based decisions.
Factors Influencing Depression and Mental Distress Related to COVID-19 Among University Students in China: Online Cross-sectional Mediation Study
Authors: Yu Yanqiu , She Rui , Luo Sitong , Xin Meiqi , Li Lijuan , Wang Suhua , Ma Le , Tao Fangbiao , Zhang Jianxin , Zhao Junfeng , Li Liping , Hu Dongsheng , Zhang Guohua , Gu Jing , Lin Danhua , Wang Hongmei , Cai Yong , Wang Zhaofen , You Hua , Hu Guoqing , Lau Joseph Tak-Fai 
Published: February 2021

Background
The COVID-19 epidemic may elevate mental distress and depressive symptoms in various populations in China.

Objective
This study investigates the levels of depression and mental distress due to COVID-19, and the associations between cognitive, behavioral, and psychosocial factors, and depression and mental distress due to COVID-19 among university students in China.

Methods
A large-scale online cross-sectional study (16 cities in 13 provinces) was conducted among university students from February 1 to 10, 2020, in China; 23,863 valid questionnaires were returned. The Patient Health Questionnaire-9 was used to assess depression. Structural equation modeling was performed to test mediation and suppression effects.

Results
Of the 23,863 participants, 47.1% (n=11,235) reported high or very high levels of one or more types of mental distress due to COVID-19; 39.1% (n=9326) showed mild to severe depression. Mental distress due to COVID-19 was positively associated with depression. All but one factor (perceived infection risks, perceived chance of controlling the epidemic, staying at home, contacted people from Wuhan, and perceived discrimination) were significantly associated with mental distress due to COVID-19 and depression. Mental distress due to COVID-19 partially mediated and suppressed the associations between some of the studied factors and depression (effect size of 6.0%-79.5%).

Conclusions
Both mental distress due to COVID-19 and depression were prevalent among university students in China; the former may have increased the prevalence of the latter. The studied cognitive, behavioral, and psychosocial factors related to COVID-19 may directly or indirectly (via mental distress due to COVID-19) affect depression. Interventions to modify such factors may reduce mental distress and depressive symptoms during the COVID-19 epidemic.
State of the Art in Adoption of Contact Tracing Apps and Recommendations Regarding Privacy Protection and Public Health: Systematic Review
Authors: Kolasa Katarzyna , Mazzi Francesca , Leszczuk-Czubkowska Ewa , Zrubka Zsombor , Péntek Márta 
Published: February 2021

Background
During the COVID-19 pandemic, contact tracing apps have received a lot of public attention. The ongoing debate highlights the challenges of the adoption of data-driven innovation. We reflect on how to ensure an appropriate level of protection of individual data and how to maximize public health benefits that can be derived from the collected data.

Objective
The aim of the study was to analyze available COVID-19 contact tracing apps and verify to what extent public health interests and data privacy standards can be fulfilled simultaneously in the process of the adoption of digital health technologies.

Methods
A systematic review of PubMed and MEDLINE databases, as well as grey literature, was performed to identify available contact tracing apps. Two checklists were developed to evaluate (1) the apps’ compliance with data privacy standards and (2) their fulfillment of public health interests. Based on both checklists, a scorecard with a selected set of minimum requirements was created with the goal of estimating whether the balance between the objective of data privacy and public health interests can be achieved in order to ensure the broad adoption of digital technologies.

Results
Overall, 21 contact tracing apps were reviewed. In total, 11 criteria were defined to assess the usefulness of each digital technology for public health interests. The most frequently installed features related to contact alerting and governmental accountability. The least frequently installed feature was the availability of a system of medical or organizational support. Only 1 app out of 21 (5%) provided a threshold for the population coverage needed for the digital solution to be effective. In total, 12 criteria were used to assess the compliance of contact tracing apps with data privacy regulations. Explicit user consent, voluntary use, and anonymization techniques were among the most frequently fulfilled criteria. The least often implemented criteria were provisions of information about personal data breaches and data gathered from children. The balance between standards of data protection and public health benefits was achieved best by the COVIDSafe app and worst by the Alipay Health Code app.

Conclusions
Contact tracing apps with high levels of compliance with standards of data privacy tend to fulfill public health interests to a limited extent. Simultaneously, digital technologies with a lower level of data privacy protection allow for the collection of more data. Overall, this review shows that a consistent number of apps appear to comply with standards of data privacy, while their usefulness from a public health perspective can still be maximized.
Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial
Authors: Hood Anna M , Strong Heather , Nwankwo Cara , Johnson Yolanda , Peugh James , Mara Constance A , Shook Lisa M , Brinkman William B , Real Francis J , Klein Melissa D , Hackworth Rogelle , Badawy Sherif M , Thompson Alexis A , Raphael Jean L , Yates Amber M , Smith-Whitley Kim , King Allison A , Calhoun Cecelia , Creary Susan E , Piccone Connie M , Hildenbrand Aimee K , Reader Steven K , Neumayr Lynne , Meier Emily R , Sobota Amy E , Rana Sohail , Britto Maria , Saving Kay L , Treadwell Marsha , Quinn Charles T , Ware Russell E , Crosby Lori E 
Published: February 2021

Background
Sickle cell anemia (SCA) is a genetic blood disorder that puts children at a risk of serious medical complications, early morbidity and mortality, and high health care utilization. Until recently, hydroxyurea was the only disease-modifying treatment for this life-threatening disease and has remained the only option for children younger than 5 years. Evidence-based guidelines recommend using a shared decision-making (SDM) approach for offering hydroxyurea to children with SCA (HbSS or HbS/β0 thalassemia) aged as early as 9 months. However, the uptake remains suboptimal, likely because caregivers lack information about hydroxyurea and have concerns about its safety and potential long-term side effects. Moreover, clinicians do not routinely receive training or tools, especially those that provide medical evidence and consider caregivers’ preferences and values, to facilitate a shared discussion with caregivers.

Objective
The aim of this study is to understand how best to help parents of young children with sickle cell disease and their clinicians have a shared discussion about hydroxyurea (one that considers medical evidence and parent values and preferences).

Methods
We designed our study to compare the effectiveness of two methods for disseminating hydroxyurea guidelines to facilitate SDM: a clinician pocket guide (ie, usual care) and a clinician hydroxyurea SDM toolkit (H-SDM toolkit). Our primary outcomes are caregiver reports of decisional uncertainty and knowledge of hydroxyurea. The study also assesses the number of children (aged 0-5 years) who were offered and prescribed hydroxyurea and the resultant health outcomes.

Results
The Ethics Committee of the Cincinnati Children’s Hospital Medical Center approved this study in November 2017. As of February 2021, we have enrolled 120 caregiver participants.

Conclusions
The long-term objective of this study is to improve the quality of care for children with SCA. Using multicomponent dissemination methods developed in partnership with key stakeholders and designed to address barriers to high-quality care, caregivers of patients with SCA can make informed and shared decisions about their health.

Trial Registration
ClinicalTrials.gov NCT03442114; https://clinicaltrials.gov/ct2/show/NCT03442114

International Registered Report Identifier (IRRID)
DERR1-10.2196/27650
PENGARUH BERMAIN GAME ONLINE TERHADAP PRESTASI BELAJAR MATEMATIKA SISWA
Authors: Ramadhan Iqbal 
Published: February 2021

AbstrakPerkembangan dunia game online saat ini sudah sangat pesat. Fenomena kecanduan bermain game online diperkirakan sangat mempengaruhi prestasi belajar siswa. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh bermain game online terhadap prestasi belajar siswa. Penelitian menggunakan metode deskriptif kuantitatif yang menggunakan teknik puppossive sampling kriteria inklusi. Penelitian ini dilakukan di SMPN 3 Plered Cirebon dengan jumlah sampel 32 responden. Hasil penelitian menunjukkan bahwa tingkat kecanduan siswa terhadap bermain game online adalah kategori sedang, nilai prestasi belajar matematika siswa paling dominan dengan interval nilai 81-85 adalah kategori baik atau predikat B. Selain itu, mayoritas pemain adalah laki-laki, penggunaan bermain game online dalam seminggu adalah 3 sampai 4 kali, alasan bermain adalah menghilangkan stress dan jenis game online yang dominan dimainkan adalah mobile legends. Berdasarkan data empirik yang digunakan dalam penelitian ini menunjukkan bahwa bermain game online berpengaruh negatif terhadap prestasi belajar matematika siswa, namun tidak signifikan, pada taraf signifikansi 5%. Kata kunci: Kecanduan Bermain, Game Online, Prestasi Belajar. AbstractNowdays the proliferation of the online gaming was phenomenal. The phenomenon of addiction to playing online games is estimated to greatly affect student achievement. This study aims to determine how much influence playing game online has on student achievement. This research was conducted using quantitative descriptive methode with puppossive sampling inclusion criteria. This research was conducted at SMPN 3 Plered Cirebon with 32 respondents. The results showed that the level of student addiction in a middle category, the most dominant value of students' mathematical feat with intervals of 81-85 was a good category or predicate B. In addition, the majority of players were male, playing game online in a week is 3 to 4 times, caused by stress relief and the game is mobile legends in general. Based on empirical data used in this study shows that playing game online has a negative effect on students' mathematical feat, but not significantly, at a significance level of 5%. Keywords: Addiction to Play, Game Online, Learning Achievement.
Aliansi Negara Komunis dan Fundamentalis Agama dalam Melindungi Posisi Nicolas Maduro dari Tekanan Politik Internasional Negara Barat
Authors: Nuswantoro Bagus Subekti 
Published: February 2021

This paper seeks to provide a view that international relations after the Cold War remains dominated by the interests of superpowers such as the United States, China and Russia. This can be seen from the behavior of these countries in influencing Venezuela. On the other hand, Turkey as a country with an Islamic Fundamentalist character under Erdogan's leadership was involved in the struggle for influence in Venezuela. What's interesting is that in this condition Turkey was in the ranks of China and Russia to support the Nicolas Maduro Government. The aim of this study is to look at the efforts of the Communist ideology (Russian) and Islamic Fundamentalism (Turkey) state in defending Nicolas Maduro's position as president of Venezuela from Western pressure.
Aplikasi Berbasis Blockchain dalam Dunia Pendidikan dengan Metode Systematics Review
Authors: Aini Qurotul , Rahardja Untung , Santoso Nuke Puji Lestari , Oktariyani Anggun 
Published: February 2021

Penemuan teknologi baru serta koneksi yang meluas berperan penting pada aspek kehidupan sehari-hari. Dengan perkembangan teknologi saat ini sistem pendidikan yang terbaru telah dikembangkan namun mengalami kendala terkait proses pembelajaran, pembayaran, kepercayaan siswa, serta sertifikasi sertifikat. Dengan begitu, teknologi blockchain hadir memperoleh sorotan yang besar dari para periset serta praktisi. Perihal ini atensi yang paling utama disebabkan oleh fitur unik yang dimiliki teknologi blockchain yaitu terkait sistem desentralisasi, keamanan, serta dalam berbagi data. Penyelesaian dalam permasalahan pembelajaran bersumber pada teknologi blockchain. Dengan metode terpercaya serta terdistribusi dalam menyimpan catatan pendidikan pada teknologi blockchain, terciptanya sistem berbagi dalam sumber pembelajaran, berbagi sertifikat digital yang kredibel, serta mengamankan intelektual lewat enkripsi informasi. Riset menampilkan bahwa integrasi pertumbuhan teknologi blockchain merupakan tren yang sangat efektif dalam dunia pendidikan. Penyimpanan informasi blockchain menggunakan database terdistribusi, dan sebagai pencatat blok data. Dalam tahapan penyusunan bersumber pada stempel waktu. Pada bok informasi yang baru tidak bisa dihilangkan. Meminimalisir penghancuran informasi serta menurunkan tingkat penipuan adalah fungsi dari algoritma kriptografi. Dalam perkembangan, hampir seluruh pembelajaran sentralisasi memberikan kursus mutu yang monoton. serta kurangnya pengakuan publik atas sistem sertifikasi yang efisien. Pencatatan informasi penyusunan teknologi blockchain memberikan metode yang efektif dalam pencatatan informasi pembelajaran Ulasan ini merupakan Tinjauan sistematis studi menyelidiki aplikasi pembelajaran berbasis blockchain. Dalam Suatu analisis hasil rinci dari tiap tema dicoba dan juga dialog intensif berdasarkan penemuan. Tinjauan ini juga menawarkan wawasan ke wilayah pembelajaran yang lain yang bisa mengambil faedah dari teknologi blockchain.
ANALYSIS OF FACTORS AFFECTING POVERTY IN NORTH SUMATERA PROVINCE (CASE STUDY IN 33 DISTRICT / CITY)
Authors: Avandi Yudistira 
Published: February 2021

The equitable poverty reduction in North Sumatera became one of the unresolved issues until now. The decreasing of poverty percentage in the last five years in North Sumatera can not represent the level of public welfare. In fact , in 2013, there were 22 out of 33 districts in North Sumatera which have the poverty percentage more than ten percent and known as hardcore poverty. The highest poverty percentage was found in North Nias and Gunung Sitoli by 30.94 %, while the lowest was found in Deli Serdang by 4.71 %. This research stated the problem “How is the influence of the economic growth, level of education, and the minimum regional wages toward the level of poverty in North Sumatera Province? The objective is to analyze the influence of economic growth, the level of education and the minimum wages toward the poor population in North Sumatera Province. This research used 165 samples that spread in 33 districts in North Sumatera from 2009 until 2013 with panel data and using Fixed Effect Model Method. The result of the Ordinary Least Square Method (LOS) through the multiple linear regretion estimated model showed that the economic growth and the minimum regional wages had negative influence, while the level of education had positive influence toward poverty in North Sumatera. The coefficient of determination (R2) is 0.948157 which means the variable of economic growth, minimum regional wages and level of education can define the poverty in North Sumatera by 94.82 %, and 5.18 % defined by other economic variables outside the model.
Puiggrós A. (2019). El pensamiento de Paulo Freire en tiempo presente. Conferencia de inauguración de la Cátedra Libre Paulo Freire de la UNLP
Authors: Aprigliano María , Larroca Sabrina 
Published: February 2021

Reseña de la Tesis "La enseñanza de la Matemática en aulas plurigrado. Un estudio de caso sobre un Instituto Superior de Formación Docente de la provincia de Buenos Aires" por M. Escobar
Sosialisasi Bencana Geologi dan Mitigasinya di Sekolah Dasar Islam Terpadu (SDIT) Ar-Rahmah Makassar
Authors: Farida Meutia , Alimuddin Ilham , Maulana Adi , Irfan Ulva Ria , Jaya Asri , - Sultan , - Kaharuddin , - Agustinus 
Published: February 2021

Kondisi Indonesia yang rawan bencana menyebabkan besarnya dampak yang dialami baik karena jatuhnya korban jiwa, kerugian materil antara lain rusaknya/hancurnya infrastruktur dan fasilitas vital lainnya. Mengingat dampak tersebut, maka pengetahuan dan pemahaman masyarakat mengenai bencana alam dan bagaimana upaya yang harus dilakukan bila terjadi bencana alam perlu dilakukan edukasi sejak dini. Peristiwa bencana alam geologi memerlukan manajemen resiko penanggulangan bencana baik sebelum, pada saat bencana maupun pasca bencana. Mitigasi adalah serangkaian kegiatan yang dilakukan untuk mengurangi resiko bencana dan termasuk dalam tahap awal manajemen bencana alam. Tentu saja kegiatan memberikan informasi bencana geologi dan mitigasinya menjadi salah satu tanggung jawab kami sebagai ahli geologi dalam lingkup akademisi untuk memberikan pengetahuan dan pemahaman kepada masyarakat yang awam, salah satu sasarannya adalah anak usia dini atau siswa sekolah dasar. Luaran dari kegiatan ini adalah peningkatan kapasitas masyarakat khususnya siswa sekolah dasar untuk memahami sejak dini pentingnya mitigasi bencana dalam upaya mengurangi atau meminimalisir kerugian akibat bencana geologi. Kegiatan ini dilaksanakan dengan metode ceramah dan simulasi beberapa kejadian bencana geologi, pengenalan tas siaga bencana termasuk pengenalan mengenai K3 (Keselamatan dan Kesehatan Kerja) baik di rumah, jalan dan di sekolah.
Sosialisasi Sistem Keselamatan Penumpang Angkutan Penyeberangan Bira-Pamatata
Authors: Rahman Sabaruddin 
Published: February 2021

Kecelakaan KMP. Lestari Maju yang terjadi pada tanggal 3 Juli 2018 mengakibatkan jatuhnya korban jiwa. Kecelakan tersebut diakibatkan oleh air yang naik ke geladak kendaraan karena gelombang tinggi. Jatuhnya korban jiwa diakibatkan kurangnya pemahaman penumpang terkait prosedur keselamatan di atas kapal saat terjadi kecelakan. Hal ini didasarkan dari hasil penyelidikan KNKT yang menjelaskan bahwa penumpang panik dan terjadi perebutan jaket penolong sehingga beberapa penumpang tidak sempat mengenakan jaket penolong. Padahal berdasarkan data fasilitas keselamatan di atas kapal, jumlah jaket penolong mencukupi untuk jumlah penumpang yang ada saat terjadi kecelakaan. Selain itu, tidak ada instruksi dari awak kapal untuk terjun ke laut sehingga penumpang menyelamatkan diri masing-masing. Bahkan ada yang terjun ke laut tanpa mengenakan jaket penolong. Dari hasil investigasi KNKT tersebut pula ditemukan bahwa awak kapal tidak pernah melakukan pelaksanaan safety drill terutama pelatihan keselamatan orang meninggalkan kapal (abandon ship). Kurangnya penerapan ISM Code dan pengawasan terhadap kinerja awak kapal berimbas pada kurangnya kesigapan awak kapal pada saat terjadi kecelakaan.
Melalui kegiatan ini dilaksanakan sosialisasi prosedur keselamatan di atas sarana angkutan penyeberangan Bira-Pamatata. Sebelum dilakukan sosialisasi, terlebih dahulu dilakukan survey untuk mengetahui kondisi eksisting alat keselamatan di atas kapal dan juga untuk mengetahui informasi yang belum terkomodir dalam prosedur keselamatan di atas kapal.
Berdasarkan hasil survey yang dilaksanakan, diketahui bahwa sekitar 45% responden menggunakan jasa angkutan penyeberangan tidak lebih dari tiga kali dalam dua tahun terakhir. Responden tersebut umumnya memiliki pemahaman yang relatif rendah terhadap prosedur keselamatan di atas kapal. Untuk itu pelaksanaannya harus dilaksanakan setiap kapal akan berangkat. Berdasarkan hasil evaluasi, pemahaman responen cenderung memaik setelah dilakukan pelaksanaan sosialisasi.
Pengembangan UKM Online Bagi Para Pengrajin Kapal Kayu di Kelurahan Tanah Lemo, Kecamatan Bontoharu, Kabupaten Bulukumba
Authors: Hasan Hasna 
Published: February 2021

Masyarakat di Kelurahan Tanah Lemo, Kecamatan. Bontoharu, Kabupaten BulukumbaNamun, kapal ini tidak sukses dipasarkan olehkarena sistem pemasaranya tradisional. Seringkali para pengrajin membutuhkan bantuan pihak ketiga untuk mendapatkan pembeli. Sehingga keuntungan yang mereka dapatkan tidak tinggi, padahal pembuatan kapal ini berat dan lama.
Namun, phinisi merupakan aset yang mampu diekspor, karena adanya pengakuan UNESCO mengenai phinisi sebagai karya seni yang indah.
Prosedur yang digunakan dalam melaksanakan pengabdian ini, terbagi atas beberapa subyek, antara lain :
- pengambilan data dan analisa data. Pengambilan data dilakukan dengan mengadakan wawancara dengan pengrajin
dan observasi proses pembuatan phinisi.
- desain website, dan peluncuran website. .
Output dari subyek ini berupa :
- proses pembuatan phinisi, .
- kendala dalam usaha phinisi.
- potensi kerajinan phinisi dalam menciptakan lapangan kerja dan kesejahteraan.
Kemudian tim pengabdian melakukan analisa atas data tersebut, yang hasilnya antara lain:
- menentukan tujuan pembuatan website yaitu menjadi jembatan bagi produsen dan konsumen
- merangkum beberapa hal penting yang perlu digambarkan dalam website ini.
Hasil analisa tersebut menjadi acuan dalam menyusun format website. Format website dari kerajinan phinisi ini, antara lain :
- menggambarkan phinisi bukan hanya sebagai sebuah karya seni tapi juga memilki ketangguhan berlayar hingga
keliling dunia.
- website ini perlu menggambarkan kredibilitas UKM ini, yang sering menjual phinisi hingga
Mancanegara.
Kemudian, berdasarkan format tersebut, pembuatan website dilakukan dengan teknik hand coding agar fleksibel dan mudah dimodifikasi. Capaian yang diharapkan dalam pengabdian ini adalah, memperkenalkan Phinisi di mancanegara dan memasarkankannya. Sehingga secara tidak langsung berdampak pada peningkatan kesejahteraan masyarakat lokal dan membuka lowongan pekerjaan baru.
Kesimpulannya, karena tingginya minat masyarakat terhadap Phinisi, maka pemutakhiran pemasaran dilakukan dengan perancangan websites. Website diharapkan menjadi jembatan bagi usahawan phinisi dengan konsumennya di segala penjuru dunia.