bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiology and Outcome of Peritoneal Dialysis-related Peritonitis in Elderly Patients: a Retrospective Study in Hunan Province, China
Authors: Song Panai , Yang Dong , Li Jine , Zhuo Ning , Fu Xiao , Zhang Lei , Liu Hong , Sun Lin , Liu Yinghong 
Published: April 2021

Abstract
The microbiology and outcomes of peritoneal dialysis (PD) related peritonitis in elderly patients have not been thoroughly investigated. We aimed to investigate the microbiological distribution and clinical outcome in elderly patients with PD-associated peritonitis to guide clinical practice. We conducted a prospective, one center cohort study in Hunan province, China from September 1, 2014 to December 31, 2020. Among incident patients (n =279), basic clinical characteristics, pathogen distribution and prognosis of elderly PD patients (up to 65 years, n = 64) were compared with those of PD patients aged under 65 years (n = 215). The survival rate and technical survival rate were analyzed by Kaplan-Meier method. Among the 279 patients there were 394 peritonitis episodes, including 88 in elderly group, and 306 in younger groups. G+ bacteria were the main pathogenic bacteria in both groups (43.2% and 38.0%, respectively). Staphylococcus was the most common G+ bacteria. Peritonitis caused by fungal infection was significantly higher in elderly patients (P = 0.01), however, there is no significant difference in the proportions of G + bacteria and G- bacteria between the two groups. The most common G- bacteria was Escherichia coli. Interestingly, we found that Acinetobacter baumannii, polymicrobial infection and culture negative peritonitis in the elderly patients was significantly higher than that in other patients. Additionally, elderly PD patients had higher peritonitis-related mortality (HR=7.27, P = 0.01). However, the technical survival rate was similar (P = 0.67) in both elderly and other patients. Taken together, this retrospective cohort study found that elderly patients had a higher probability of peritonitis caused by of Acinetobacter baumannii, fungi and polymicrobial infections. In addition, the elderly peritonitis patients had a higher risk of mortality. Understanding the characteristics of microbiology and clinical outcome in elderly patients will help us to take effective measures to reduce the incidence of elderly PD-associated peritonitis.
Bound in the continuum modes in indirectly-patterned hyperbolic media
Authors: Koppens Frank , Herzig-Sheinfux Hanan , Orsini Lorenzo , Jung Minwoo , Torre Iacopo , Ceccanti Matteo , Maniyara Rinu , Barcons-Ruiz David , Castilla Sebastian , Hesp Niels , Janzen Eli , Pruneri Valerio , Edgar James , Shvets Gennady 
Published: April 2021

Abstract
A conventional optical cavity supports one or more modes, which are confined since they are unable to leak out of the cavity. Bound state in continuum (BIC) cavities are an unconventional alternative, based on confinement by destructive interference, even though optical leakage channels are available. BICs are a general wave phenomenon, of particular interest to optics, but BICs have never been demonstrated at the nanoscale level. Nanoscale BIC cavities are more challenging to realize, however, as they require destructive interference at the nanometer scale. Here, we demonstrate the first nanophotonic cavities based on BIC and find an unprecedented combination of quality factors and ultrasmall mode volume. In particular, we exploit hyperbolic media, HyM, as they can support large (in principle unlimited) momentum excitations, which propagate as ultra-confined rays, so that HyM cavities can in principle be extremely small. However, building a hyperbolic BIC (hBIC) cavity presents a fundamental challenge: an hBIC has an infinite number of modes, which would all need to interfere simultaneously. Here, we bring the BIC concept to the nanoscale by introducing and demonstrating a novel multimodal reflection mechanism of the ray-like optical excitations in hyperbolic materials. Using near-field microscopy, we demonstrate mid-IR confinement in BIC-based nanocavities with volumes down to 23x23x3〖nm〗^3 and quality factors above 100 – a dramatic improvement in several metrics of confinement. This alliance of HyM with BICs yields a radically novel way to confine light and is expected to have far reaching consequences wherever strong optical confinement is utilized, from ultra-strong light-matter interactions, to mid-IR nonlinear optics and a range of sensing applications.
Impact of Super Heavy Load Vehicles on Transportation Infrastructure: Economic Aspects
Authors: Nguyen Thach , Morovatdar Ali , Ashtiani Reza , Kosheleva Olga 
Published: April 2021

Abstract
Sometimes, there is a need to transport very heavy equipment, so heavy that
the resulting load is several times larger than the maximal load that the
corresponding road segment was designed to withstand. Such super heavy load vehicles
decrease the remaining service life of the road segment, and sometimes even make the
segment unusable and needing repairs. In both cases, the need for earlier-than-expected repairs
means additional costs. It is therefore desirable to estimate the expected value of this additional cost. In locations where the owner of the super heavy load vehicle pays for the vehicle passage, this is necessary to decide how much to charge the owner. In other locations, where the agreement is that the cost of additional repairs comes from the additional taxes that the vehicle owners pay, such an estimate is needed to the road owners -- e.g., to the county or to the state -- so as to select the route for which the expected additional cost of repairs is the smallest.
Three-dimensional Semi-Automated Volumetric Assessment of the Pulp Space of Teeth with Regenerative Dental Procedures
Authors: Shetty Heeresh , Shetty Shishir , Kakade Adesh , Shetty Aditya , Karobari Mohmed Isaqali , Pawar Ajinkya M. , Marya Anand , Heboyan Artak , Venugopal Adith , Nguyen The Hanh , Rokaya Dinesh 
Published: April 2021

Abstract
Volumetric change of the pulp space over time is a critical measure to determine the outcome of regenerative endodontic procedures (REP). There is a paucity in the literature on the accuracy of domain specialized medical imaging tools for three dimensional (3D) volumetric assessment. Thus, the aim of this study was to compare two different medical image computing platforms (OsiriX MD and 3D Slicer) to estimate the volume of pulp space post REP. Pre and post CBCT Scans of 35 immature permanent teeth (n = 35) with necrotic pulp and periradicular pathosis treated with a cell-homing concept-based REP were processed using two biomedical DICOM software programs: OsiriX MD (commercially available, FDA approved) 2) and 3D Slicer (open source). Volumetric changes in the pulp space were assessed using semi-automated techniques in both the programmes. The data were statistically analyzed using t-test and paired t-test (P = 0.05). The pulp space volume measured with both the programmes showed a statistically significant decrease in pulp space volume post REP (P < 0.05), with no significant difference between the two programmes (P > 0.05). The mean decrease in pulp space volume with OsiriX MD and 3D Slicer were 25.06% ± 19.45% and 26.10.% ± 18.90% respectively. The open-source software (3D Slicer) was as accurate as the commercially available software for the volumetric assessment of the pulp space post REP. This study demonstrates the step-by-step application of 3D Slicer, a user-friendly, easily accessible, open-source multiplatform software for the segmentation and volume estimation of the pulp-space of teeth treated with REP.
Characteristic and Expression of Hsp70 and Hsp90 Genes from Tyrophagus Putrescentiae and Their Response to Thermal Stress
Authors: Wang Jing , Que Sheng-quan , Jin Meng-ru , Liu Xin-yu , Xin Tian-rong , Zou Zhi-wen , Xia Bin 
Published: April 2021

Abstract
Tyrophagus putrescentiae (T. putrescentiae) is a worldwide tored grain pest mite which has do great harm to human’s economy and health. Temperature has a great influence on the population dynamics of T. putrescentiae. In this study, the cDNA of T. putrescentiae HSP70 and HSP90 (designated TpHSP70-1, TpHSP70-2 and TpHSP90) were cloned, and their expression were determined by fluorescent real time quantitative PCR. Results indicate that TpHSP70-1, TpHSP70-2 and TpHSP90 contained an open reading frame of 1,998 bp, 1,984 bp and 2,157 bp that encoded 665, 661 and 718 amino acid residues, respectively. Sequences and phylogenetic analyses suggested that TpHSP70 and TpHSP90 showed high homology with other species. The RT-qPCR results indicated the relative expression level of TpHSP90 and TpHSP70 gene at different stages were different. Also thermal stress could increase its expression significantly. This study indicates that TpHSP70 and TpHSP90 are very important genes for T. putrescentiae to defend against thermal stress.
Growth Differentiation Factor-15 and Incident Chronic Kidney Disease: A Population-Based Cohort Study
Authors: Bao Xue , Xu Biao , Borné Yan , Orho-Melander Marju , Melander Olle , Nilsson Jan , Christensson Anders , Engström Gunnar 
Published: April 2021

Abstract
Background

The relationship between growth differentiation factor 15 (GDF-15) and the development of chronic kidney disease (CKD) is still unclear. We sought to examine whether plasma GDF-15 was related to incident CKD and kidney function decline using a large prospective cohort study.
Methods

4,318 participants of the Malmö Diet and Cancer Study-Cardiovascular Cohort were examined in 1991–1994 and followed prospectively until 2013 for incidence of CKD, as detected from national registers. Estimated glomerular filtration rate (eGFR) was available for all participants at baseline, and was re-measured in a subgroup of 2,744 subjects after 16.6 ± 1.49 years. Incidence of CKD was examined in relation to GDF-15 using Cox regression analysis. Logistic regression was used to examine the association of GDF-15 with eGFR change and eGFR-based CKD. Models were carefully corrected for potential confounders including baseline eGFR, N-terminal pro-B-type natriuretic peptide, and competing risk from death.
Results

165 patients developed CKD after 19.2 ± 4.04 years of follow-up. The adjusted hazard ratio (95% confidence interval, CI) for CKD in 4th versus 1st quartile of GDF-15 was 2.37 (1.33, 4.24) (p for trend < 0.01). Each per 1 standard deviation increase in GDF-15 was associated with a decline in eGFR of -0.97 mL/min/1.73 m2 (95% CI, -1.49~-0.45; p < 0.001). GDF-15 was also significantly associated eGFR-based CKD in 2,713 subjects with baseline eGFR ≥ 60 mL/min/1.73 m2.
Conclusions

GDF-15 predicted incidence of CKD and eGFR decline in the general population, independent of a wide range of potential risk factors and competing risk of death.
High parity is associated with increased risk of cervical cancer: Systematic review and meta-analysis of case-control studies
Authors: Tekalegn Yohannes , Sahiledengle Biniyam , Woldeyohannes Demelash , Atlaw Daniel , Desta Fikreab , Bekele Kebebe , Assefa Tesfaye , Gezahegn Habtamu , kene chala 
Published: April 2021

Abstract
Background: Cervical cancer is the fourth most common cancer among women. High parity has long been suspected with an increased risk of cervical cancer. Evidence from the existing epidemiological studies regarding the association between parity and cervical cancer is variable and inconsistent. Therefore, the objective of this systematic review and meta-analysis was to synthesize the best available evidence on the epidemiological association between parity and cervical cancer. Methods: MEDLINE/PubMed, HINARI, Google scholar, Science direct, and Cochrane Libraries were systematically searched. Cochrane Q statistics and I2 tests were performed to assess heterogeneity among included studies. Begg's test and egger's regression analysis were performed to assess publication bias. A random-effect meta-analysis model was used to compute pooled odds ratio of the association between parity and cervical cancer. Results: A total of 6975 participants (1998 patients; 4977 controls) were incorporated in the 13 articles included in the final meta-analysis. The meta-analysis revealed that women with parity greater than or equal to three had 2.4 times higher odds of developing cervical cancer compared to women with parity less than three [pooled odds ratio (POR) = 2.4, 95% CI: 1.9-3.2]. Conclusion: High parity is associated with an increased risk of cervical cancer. Strong epidemiological studies are recommended to further explore the mechanisms and role of parity in the causation of cervical cancer.
Insights into the Generalized Fourier's and Fick's Laws for Simulating Mixed Bioconvective Flows of Radiative-Reactive Walters-B Fluids Conveying Tiny Particles subject to Lorentz Force
Authors: Wakif A. , Animasaun I. L. , Khan Umair , Alshehri Ahmed Mohammed 
Published: April 2021

Abstract
The current improvement in nanoscience and nanotechnology areas has attracted researchers' attention to biofuel, bioengineering, and biomedical and mechanical engineering applications. However, there is no report on the extension of Buongiorno's model incorporating the Cattaneo-Christov theory and the generalized Fick's law to reflect the significant impacts of Brownian motion, thermophoresis diffusion, thermal radiation, and activation energy. The governing partial differential equations (PDEs) suitable to model the case as mentioned above were converted into a unified set of ordinary differential equations (ODEs) by applying appropriate similarity transformations and solved numerically by using the Spectral Local Linearization Method (SLLM) and MATLAB in-built package. The SLLM numerical method provides robustness results with a higher level of exactness and low‐computational cost. It is worthy to conclude that the nanoparticles concentration distribution can be heightened considerably either by diminishing the Prandtl number and concentration relaxation parameter or increasing the values of nanoparticles concentration Biot number and activation energy parameter. An attractive reduction in the surface drag force coefficient is achievable via the intensifying values of the non-Newtonian parameter.
Development And Research Of The Press Operating Mechanism, Made In The Form Of The Wedge-Joint Mechanism With A Curving Wedge For Separation Operations
Authors: Karnaukh Sergii G. , Chosta Nataly V. , Markov Oleg E. , Kukhar Volodymyr V. 
Published: April 2021

Abstract
The applicability of a wedge-joint mechanism with a curving wedge in presses for the implementation of metal forming separation processes was substantiated. The paper states the fact, that the wedge-joint mechanism graph of the deformation force change is the closest to the technological typical graph of the force change during separation. At the same time, the wedge-joint mechanism with a curving wedge has a lower height of the parts in comparison with the traditional crank mechanisms, which provides less elastic deformation and press dynamics. The use of the additional wedge mechanism in a press with the wedge-joint mechanism with a curving wedge to ensure the approximation motion is proved. This makes it possible to reduce the energy consumption for elastic deformation and further reduce the dynamic force. The mathematical models of the wedge-joint mechanism with a curving wedge, presented in the form of a two-slide link mechanism, were developed, allowing to perform its structural, kinematic and dynamic analysis. Based on the analysis of the proposed mathematical models, dependencies were identified and a procedure for calculating the geometric, kinematic and power parameters of wedge-joint mechanisms with a curving wedge for separation processes was developed. Comparison of the kinematic and dynamic analyzes results carried out by analytical and graphic-analytical methods confirms the reliability of estimates, since their discrepancy is not more than 2.5%. Experimental studies have confirmed the adequacy of mathematical models. The error between the calculated and measured values ​​of the forces on the slide does not exceed 10%.
Autonomous 3D geometry reconstruction through robot-manipulated optical sensors
Authors: Mineo Carmelo , Cerniglia Donatella , Ricotta Vito , Reitinger Bernhard 
Published: April 2021

Abstract
Many industrial sectors face increasing production demands and need to reduce costs, without compromising the quality. Whereas mass production relies on well-established protocols, small production facilities with small lot sizes struggle to update their highly changeable production at reasonable costs. The use of robotics and automation has grown significantly in recent years, but extremely versatile robotic manipulators are still not commonly used in small factories. Beside of the investments required to enable efficient and profitable use of robot technology, the efforts needed to program robots are only economically viable in case of large lot sizes. Generating robot programs for specific manufacturing tasks still relies on programming trajectory waypoints by hand. The use of virtual simulation software and the availability of the specimen digital models can facilitate robot programming. Nevertheless, in many cases, the virtual models are not available or there are unavoidable differences between virtual and real setups, leading to inaccurate robot programs and time-consuming manual corrections. This could be avoided by measuring the real-geometry and the position of the specimen, which creates the paradox of having to plan robot paths for surface mapping purposes, before the originally intended robot task can be approached. Previous works have demonstrated the use of robotically manipulated optical sensors to map the geometry of samples. However, the use of simple user-defined robot paths, which are not optimized to the part geometry, typically causes some areas of the samples to not be mapped with the required level of accuracy or to not be sampled at all by the optical sensor. This work presents an autonomous framework to enable adaptive surface mapping, without any previous knowledge of the part geometry being transferred to the system. The article gives an overview of the related work in the field, a detailed description of the proposed framework and a proof of its functionality through both simulated and experimental evidences.
A multicenter prospective study on the efficacy and safety of denosumab in gastrointestinal cancer patients receiving short-term periodic steroid premedication for prevention of chemotherapy-induced nausea and vomiting (ESPRESSO-02/HGCSG1602).
Authors: Nakamura Michio , Muranaka Tetsuhito , Yagisawa Masataka , Kawamoto Yasuyuki , Yuki Satoshi , Ishiguro Atsushi , Dazai Masayoshi , Kobayashi Yoshimitsu , Sogabe Susumu , Harada Kazuaki , Sawada Kentaro , Miyagishima Takuto , Tsuji Yasushi , Kikuchi Yasuka , Komatsu Yoshito 
Published: April 2021

Abstract
Purpose
We previously reported that the periodic premedication of glucocorticoids during chemotherapy for gastrointestinal cancer (GIC) caused the reduction of bone mineral densities (BMD) (ESPRESSO-01). We conducted this study to evaluate the efficacy and safety of denosumab in the prevention of chemotherapy-induced decreased BMD.
Methods
Forty-two Japanese patients were studied. Denosumab was administered as a single 60 mg subcutaneous injection before the start of chemotherapy. The primary endpoint was BMD change in the lumbar spine from baseline to 16 weeks. Secondary endpoints were changes in serum cross-linked N-telopeptides of type I collagen (sNTX) and bone alkaline phosphatase (sBAP), complications including hypocalcemia and osteonecrosis of the jaw, new bone fractures, changes in the Japanese Osteoporosis Quality of Life Questionnaire.
Results
Lumbar spine BMD significantly increased in 71.4% of cases: 2.772% (95% CI, 1.350–4.195%: P < 0.0001). There were also significant decreases in sNTX (P = 0.034) and sBAP levels (P < 0.001). Although one case (2.4%) of jaw osteonecrosis was diagnosed, no fractures occurred. In a cross-trial comparison with ESPRESSO-01, there was no significant difference in the incidence of National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) grade 3 or higher adverse events. However, inclusion of grade ≤ 2 showed significantly higher incidence of hypocalcemia with any CTCAE grade in ESPRESSO-02 (28.4% in ESPRESSO-01, 54.8% in ESPRESSO-02, P = 0.006)
Conclusion
Denosumab administration prevented secondary BMD reduction in GIC patients undergoing chemotherapy, and was associated with decreased serum levels of the bone turnover markers BAP and NTX.
Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China
Authors: Wang Xinye , Wang Dawei , Umar Sajid , Qin Sheng , Lin Qiong , Gray Gregory C. , Liu Yuntao 
Published: April 2021

Abstract
Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). Methods To understand the epidemiology and type distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV virus types. Results HAdV was detected in 99 (2.4%) of the 4,129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%) and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer. Conclusion All ages suffer adenovirus infections, but young children are at greatest risk. These study data demonstrate that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.