bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conservative management of first-time traumatic anterior shoulder dislocation
Authors: Schliemann Benedikt , Minkus Marvin , Seybold Dominik , Scheibel Markus 
Published: February 2021

AbstractTraumatic anterior shoulder dislocation is a common injury in young and active patients and the proper treatment is still a matter of debate. The recurrence rate after conservative management remains high and, therefore, primary surgical intervention is sometimes recommended in very young patients whose risk of recurrences is highest. Immobilization in external rotation, first described by Itoi, is a promising conservative option as it provides adequate labral reduction and low recurrence rates. Recent meta-analyzes could not unequivocally demonstrate its superiority over internal rotation immobilization. However, biomechanical and early clinical results show a better effect on reduction of the labrum and lower recurrence rates for immobilization in a combination of abduction/external rotation than for external rotation alone. The present article aims to provide an overview of the conservative management of first-time traumatic shoulder dislocation in order to provide the treating physician or surgeon with the best current evidence as a basis for developing the appropriate treatment strategy for the patient.
Labral lesions in first-time traumatic anterior shoulder dislocation: it’s more than just Bankart …
Authors: Schliemann B. , Dyrna F. , Kravchenko V. , Raschke M. J. , Katthagen J. C. 
Published: February 2021

AbstractIntroductionTraumatic anterior shoulder dislocation occurs frequently and usually affects young, active male patients. Detachment of the anteroinferior labrum, known as the Bankart lesion, is a common result. However, more extensive entities including bony lesions and disruptions of the labral ring can also be found. The aim of the present work was to analyze all cases of first-time traumatic anterior shoulder dislocation at a level‑1 trauma center with regard to the type of labral lesion. Focus was placed on the frequency and distribution of complex lesions and the extent of the surgical repair.Patients and methodsThe clinical database of a level‑1 trauma center with a specialized shoulder unit was searched to identify all patients with first-time anterior shoulder dislocation treated between 2015 and 2019. Of 224 patients, 110 underwent primary surgical repair after first-time dislocation (mean age 40 years).ResultsA total of 62% of patients had only a soft tissue injury, while 38% (n = 40) showed a bony Bankart lesion/fracture of the glenoid fossa with a mean defect size of 26%. In only 31% of patients (n = 34), a classicBankart repair was performed, whereas the remaining 69% underwent additional procedures.ConclusionIn this series of surgically treated first-time traumatic anterior shoulder dislocations, the majority of cases presented with more complex lesions than an isolated classic Bankart lesion. The risk for bony involvement and associated pathologies, such as cuff tears and greater tuberosity fracture, increases with age and requires a more extensive surgical approach. Disruption of the labral ring was frequently found in both soft tissue and bony lesions and directly affected the surgical procedure.
A column-and-constraint generation algorithm for two-stage stochastic programming problems
Authors: Tönissen Denise D. , Arts Joachim J. , Shen Zuo-Jun Max 
Published: February 2021

AbstractThis paper presents a column-and-constraint generation algorithm for two-stage stochastic programming problems. A distinctive feature of the algorithm is that it does not assume fixed recourse and as a consequence the values and dimensions of the recourse matrix can be uncertain. The proposed algorithm contains multi-cut (partial) Benders decomposition and the deterministic equivalent model as special cases and can be used to trade-off computational speed and memory requirements. The algorithm outperforms multi-cut (partial) Benders decomposition in computational time and the deterministic equivalent model in memory requirements for a maintenance location routing problem. In addition, for instances with a large number of scenarios, the algorithm outperforms the deterministic equivalent model in both computational time and memory requirements. Furthermore, we present an adaptive relative tolerance for instances for which the solution time of the master problem is the bottleneck and the slave problems can be solved relatively efficiently. The adaptive relative tolerance is large in early iterations and converges to zero for the final iteration(s) of the algorithm. The combination of this relative adaptive tolerance with the proposed algorithm decreases the computational time of our instances even further.
Buckling Properties of a Subsea Function Chamber for Oil/Gas Processing in Deep Waters
Authors: Al-Hamati Amer Ali , Duan Menglan , An Chen , Guedes Soares C. , Estefen Segen 
Published: February 2021

AbstractDue to the complexity of installations and connections of subsea production equipment and the massive structures involved in a challenging environment, the failure of subsea production equipment could induce enormous loss to the safety and reliability of structures in addition to the cost of the oilfield development. One of the challenges that the subsea production structures face, as it moves to ultra-deep water and polar underwater equipment, is to design subsea shell structures capable of withstanding high external pressures. Hence, a subsea function chamber (SFC) has been lately proposed as a viable solution, which has a high level of safety and reliability, and a technique for the subsea production system. This paper presents a general and efficient buckling and collapse analysis strategy. In this work, the SFC is composed of cylindrical and hemispherical shaped steel material. Initial imperfection-based nonlinear buckling analysis has been carried out to investigate the buckling and risks associated with different thicknesses of the structure. Linear and nonlinear static buckling analyses have been carried out using ABAQUS software. By introducing the nonlinear properties of materials, the nonlinear numerical model of SFC is established. The effects of the thickness of different models and the number of stiffeners on the buckling modes are discussed. The wall thickness is calculated by the Donnell equation and Timoshenko’s classical method. It has been found that the classical solutions given by the Donnell and Timoshenko equations are more accurate for structures with larger lengths and diam. The thickness and number of stiffeners have a great influence on the ultimate buckling external pressure load of SFC structure
Contextualizing Security Innovation: Responsible Research and Innovation at the Smart Border?
Authors: Klimburg-Witjes Nina , Huettenrauch Frederik C. 
Published: February 2021

AbstractCurrent European innovation and security policies are increasingly channeled into efforts to address the assumed challenges that threaten European societies. A field in which this has become particularly salient is digitized EU border management. Here, the framework of responsible research and innovation (RRI) has recently been used to point to the alleged sensitivity of political actors towards the contingent dimensions of emerging security technologies. RRI, in general, is concerned with societal needs and the engagement and inclusion of various stakeholder groups in the research and innovation processes, aiming to anticipate undesired consequences of and identifying socially acceptable alternatives for emerging technologies. However, RRI has also been criticized as an industry-driven attempt to gain societal legitimacy for new technologies. In this article, we argue that while RRI evokes a space where different actors enter co-creative dialogues, it lays bare the specific challenges of governing security innovation in socially responsible ways. Empirically, we draw on the case study of BODEGA, the first EU funded research project to apply the RRI framework to the field of border security. We show how stakeholders involved in the project represent their work in relation to RRI and the resulting benefits and challenges they face. The paper argues that applying the framework to the field of (border) security lays bare its limitations, namely that RRI itself embodies a political agenda, conceals alternative experiences by those on whom security is enacted upon and that its key propositions of openness and transparency are hardly met in practice due to confidentiality agreements. Our hope is to contribute to work on RRI and emerging debates about how the concept can (or cannot) be contextualized for the field of security—a field that might be more in need than any other to consider the ethical dimension of its activities.
Pathways of Neutrophil Granulocyte Activation in Hereditary Angioedema with C1 Inhibitor Deficiency
Authors: Kajdácsi Erika , Veszeli Nóra , Mező Blanka , Jandrasics Zsófia , Kőhalmi Kinga Viktória , Ferrara Anne Lise , Cervenak László , Varga Lilian , Farkas Henriette 
Published: February 2021

AbstractHereditary angioedema (HAE) with C1-inhibitor deficiency belongs to bradykinin-mediated angioedemas. It is characterized by recurrent subcutaneous and/or submucosal swelling episodes (HAE attacks) and erythema marginatum skin rash as a pre-attack (prodromal) phase. HAE attacks were shown to be accompanied by peripheral blood neutrophilia. We aimed to find molecular mechanisms that may explain the distinct role of neutrophil granulocytes in HAE. Plasma levels of blood cells and factors related to neutrophil activation (cytokines, chemokines, chemotactic factors, enzymes, and neutrophil extracellular trap) were measured in plasma samples obtained from patients during symptom-free periods (n = 77), during prodromal phase (n = 8) and attacks (n = 14), during a spontaneously resolved attack (n = 1), and in healthy controls (n = 79). Higher counts of white blood cells, lymphocytes, and neutrophil granulocytes were found in symptom-free patients compared with controls; these cell counts were elevated further during HAE attacks. The level of chemokine (C–C motif) ligand 5, monocyte chemoattractant protein-1, and myeloperoxidase were also higher in the symptom-free patients than in the controls. Levels of monocyte chemoattractant protein-1, leukotriene B4, neutrophil elastase, and myeloperoxidase were elevated during attacks. During erythema marginatum, white blood cells and monocyte count and levels of interleukin 8 were elevated compared with symptom-free period. Similar changes were detected during the attack follow-up. We conclude that the activation of NGs in symptom-free periods and a further increase observed during attacks suggests that NGs may be involved in the pathomechanism of HAE with C1-INH deficiency.
Sternectomy for Candida albicans sternal osteomyelitis after left ventricular assist device implantation
Authors: Van Hemelrijck Mathias , Frank Michelle , Zinkernagel Annelies S. , Buechel Ronny , Sromicki Juri , Wilhelm Markus J. , Klein Holger , Hasse Barbara , Mestres Carlos A. 
Published: February 2021

AbstractFungal osteomyelitis is an uncommon complication after cardiac surgery and associated with high mortality. A case of Candida albicans and Staphylococcus epidermidis osteomyelitis with device infection after implantation of a left ventricular assist device in a 60-year-old male patient is presented here. After clinical identification and confirmation with microbiological examinations and fluorodeoxyglucose positron emission tomography (FDG-PET) scan, debridement was performed. Surgical specimens grew C. albicans and S. epidermidis. Fluconazole, daptomycin, and negative pressure wound therapy were initiated, but failed to achieve healing. Total sternectomy and pectoralis flap reconstruction were performed. There was no recurrent infection for C. albicans on a prolonged antifungal regime. The combination of antifungal therapy and aggressive surgical debridement may be useful to control fungal osteomyelitis.
Glucose-limiting conditions induce an invasive population of MDA-MB-231 breast cancer cells with increased connexin 43 expression and membrane localization
Authors: Jones Jennifer C. , Miceli Amanda M. , Chaudhry Mary M. , Kaunitz Chloe S. , Jai Mallika A. , Pancho Romel N. , Lazzar Alan , Taylor Bradley S. , Bodempudi Vishnupriya , Jain Prarthana P. , Hanjra Sheeri , Urban Alexander E. , Zanotti Brian , Kohlmeir Ellen K. , Bodenstine Thomas M. 
Published: February 2021

AbstractGap junctional intercellular communication (GJIC) is a homeostatic process mediated by membrane channels composed of a protein family known as connexins. Alterations to channel activity can modulate suppression or facilitation of cancer progression. These varying roles are influenced by the cancer cell genetic profile and the context-dependent mechanisms of a dynamic extracellular environment that encompasses fluctuations to nutrient availability. To better explore the effects of altered cellular metabolism on GJIC in breast cancer, we generated a derivative of the triple-negative breast cancer cell line MDA-MB-231 optimized for growth in low-glucose. Reduced availability of glucose is commonly encountered during tumor development and leads to metabolic reprogramming in cancer cells. MDA-MB-231 low-glucose adapted cells exhibited a larger size with improved cell–cell contact and upregulation of cadherin-11. Additionally, increased protein levels of connexin 43 and greater plasma membrane localization were observed with a corresponding improvement in GJIC activity compared to the parental cell line. Since GJIC has been shown to affect cellular invasion in multiple cancer cell types, we evaluated the invasive qualities of these cells using multiple three-dimensional Matrigel growth models. Results of these experiments demonstrated a significantly more invasive phenotype. Moreover, a decrease in invasion was noted when GJIC was inhibited. Our results indicate a potential response of triple-negative breast cancer cells to reduced glucose availability that results in changes to GJIC and invasiveness. Delineation of this relationship may help elucidate mechanisms by which altered cancer cell metabolism affects GJIC and how cancer cells respond to nutrient availability in this regard.
Can Animals Refer? Meta-Positioning Studies of Animal Semantics
Authors: Ongstad Sigmund 
Published: February 2021

AbstractThis meta-study applies a socio-semiotic framework combining five basic communicational aspects, form, content, act, time, and space, developed to help answering the questionCan animals refer?It further operates with four levels, sign, utterance, genre, and lifeworld, studying relations between utterance and genre in particular. Semantic key terms found in an excerpted ‘resource collection’ consisting of three anthologies, two academic journals, and a monography, studying content in animal communication, are inspected, and discussed, especially information, functional reference, and reference. Since a temporary inspection concluded that the field seems unable to give convincing joint answers, the scope of the meta-study was extended to include critical investigations of implicit communicational epistemologies applied in the sources. Two major challenges were brought to surface. Firstly, the problem of conflicting interrelatedness in animal utterances (parts versus whole). Positioning analyses revealed that theories and project-designs were mostly dyadic, prioritising form/content, content/function, or function/form, and rarely form/content/function, as a whole. The second concerned the issue of functional openness of animal communication systems. The meta-study found that more recent studies tend to reduce an essentialist search for ‘clear’ categories in favor of more complex designs, where focus is less on references in utterances as such and more on a species’ communicational system. This shift in turn leads to a problematisation of the role of context, kinds of communication (life-genres) and semantic levels in animal utterances, in other words, on animal communication for particular species as a whole.
Infantile Hämangiome
Authors: Volc-Platzer Beatrix 
Published: February 2021

ZusammenfassungDie Prävalenz des infantilen Hämangioms beträgt 4,5 %. Am häufigsten finden sich Hämangiome am Stamm und an den Extremitäten. Risikolokalisationen sind der Kopf-Hals- und der Anogenitalbereich. Charakteristisch ist ein rasches Wachstum bis zum Erreichen von ca. 80 % der maximalen Größe bis zum Ende des dritten Lebensmonats. Auf die Wachstumsphase folgt eine spontane Regression bis zum Ende des 4. Lebensjahres. Die meisten Hämangiome sind unkompliziert, klein und erfordern keine Therapie. Dennoch sind engmaschige Kontrollen in den ersten Lebenswochen erforderlich, um IH mit erhöhtem Risiko rechtzeitig zu identifizieren und zu behandeln. Zu den Indikationen für eine Behandlung zählen Einschränkung der Atmung durch paraglottische oder -tracheale Lokalisation, eine drohende Herzinsuffizienz bei großen Hämangiomen, funktionelle Einschränkungen bis zur Amblyopie bei periokulärer Lokalisation, Behinderung der Nasenatmung durch IH am Naseneingang, Ulzeration von IH im Lippen- oder Genitalbereich, und – last but not least – kosmetische Beeinträchtigungen. Die Entdeckung des therapeutischen Potenzials von oralem Propranolol hat nicht nur das Therapiekonzept revolutioniert, sondern auch neue Erkenntnisse für die vaskuläre Biologie ermöglicht. Trotz raschen Ansprechens auf den systemischen Betablocker sollte eine Therapiedauer von 6 Monaten nicht unterschritten werden. Dermatologen und Dermatologinnen, Pädiater und Pädiaterinnen sowie Allgemeinmediziner sind gefordert, Hämangiome so früh wie möglich zu erkennen, um Risiko-Hämangiome im frühen Stadium der Proliferation zu erkennen und eine adäquate Therapie zu ermöglichen. Klinische Studien zur Evaluierung der Langzeitsicherheit von Propranolol sind erforderlich.
Was kommt dort durch die Luft geflogen …?
Authors: Maier Harald 
Published: February 2021

ZusammenfassungDie Larven des 4. bis 6. Stadiums des Eichenprozessionspinners sind mit Brennhärchen (Setae) bewehrt, welche bei Mensch und Tier heftige entzündliche Haut- und Schleimhautreaktionen (Lepidopterismus) hervorrufen. Die Übertragung erfolgt sehr häufig aerogen, oder durch direkten Kontakt. Durch den Befall von Bäumen im urbanen Grünbereich ist die Fallzahl – vor allem in Jahren mit Massenvermehrung des Forstparasiten – sehr groß. Da die Dunkelziffer sehr hoch ist, sollten Ärzte und Ärztinnen bei Patienten mit juckenden, asymmetrisch verteilten papulösen oder urtikariellen Exanthemen an die Möglichkeit des Vorliegens einer Raupendermatitis denken. Meiden der Befallsgebiete bzw. Tragen von persönlicher Schutzkleidung bei Außenarbeitern, stellen die besten präventiven Maßnahmen dar.
Moral Uncanny Valley: A Robot’s Appearance Moderates How its Decisions are Judged
Authors: Laakasuo Michael , Palomäki Jussi , Köbis Nils 
Published: February 2021

AbstractArtificial intelligence and robotics are rapidly advancing. Humans are increasingly often affected by autonomous machines making choices with moral repercussions. At the same time, classical research in robotics shows that people are adverse to robots that appear eerily human—a phenomenon commonly referred to as the uncanny valley effect. Yet, little is known about how machines’ appearances influence how human evaluate their moral choices. Here we integrate the uncanny valley effect into moral psychology. In two experiments we test whether humans evaluate identical moral choices made by robots differently depending on the robots’ appearance. Participants evaluated either deontological (“rule based”) or utilitarian (“consequence based”) moral decisions made by different robots. The results provide first indication that people evaluate moral choices by robots that resemble humans as less moral compared to the same moral choices made by humans or non-human robots: a moral uncanny valley effect. We discuss the implications of our findings for moral psychology, social robotics and AI-safety policy.
The role of social trust in reward crowdfunding campaigns’ design and success
Authors: Shneor Rotem , Mrzygłód Urszula , Adamska-Mieruszewska Joanna , Fornalska-Skurczyńska Anna 
Published: February 2021

AbstractTrust is critical for successful participation in online marketplaces. In crowdfunding, fundraisers seek to win the trust of potential supporters towards contributing to their projects despite risks of non-delivery or deviations from campaign promises. This study explores how cultural differences in social trust proclivities influence reward crowdfunding campaign design and success. Specifically, we analyze data about 700 campaigns from a relatively high social trust society (HTS) – Finland, and 700 campaigns from a relatively low social trust society (LTS) – Poland. We find that sharing campaign information via social media is positively associated with campaign success in both contexts. Building on the Elaboration Likelihood Model, we show that central route cues to persuasion are more prevalent in campaigns from LTS vs. HTS, and that some peripheral cues are more prevalent in campaigns from HTS than LTS. Finally, we find partial support that central route cues are more important for campaign success in LTS.
Understanding continued smartwatch usage: the role of emotional as well as health and fitness factors
Authors: Siepmann Carolin , Kowalczuk Pascal 
Published: February 2021

AbstractSmartwatches are the most popular wearable device and increasingly subject to empirical research. In recent years, the focus has shifted from revealing determinants of smartwatch adoption to understanding factors that cause long-term usage. Despite their importance for personal fitness, health monitoring, and for achieving health and fitness goals, extant research on the continuous use intention of smartwatches mostly disregards health and fitness factors. Grounding on self-determination theory, this study addresses this gap and investigates the impact of health and fitness as well as positive and negative emotional factors encouraging or impeding consumers to continuously use smartwatches. We build upon the expectation-confirmation model (ECM) and extend it with emotional (device annoyance and enjoyment) as well as health and fitness factors (goal pursuit motivation and self-quantification behavior). We use structural equation modeling to validate our model based on 335 responses from actual smartwatch users. Results prove the applicability of the ECM to the smartwatch context and highlight the importance of self-quantification as a focal construct for explaining goal pursuit motivation, perceived usefulness, confirmation and device annoyance. Further, we identify device annoyance as an important barrier to continuous smartwatch use. Based on our results, we finally derive implications for researchers and practitioners alike.