bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of non-Newtonian rheology in the upper mantle on relative sea level change and geodetic observables induced by glacial isostatic adjustment process
Authors: Kang Kaixuan , Zhong Shijie , Geruo A , Mao Wei 
Published: October 2021

SUMMARY
Studies of glacial isostatic adjustment (GIA) provide important constraints on the Earth's mantle viscosity. Most GIA models assume Newtonian viscosity through the mantle, but laboratory experimental studies of rock deformation, observational studies of seismic anisotropy, and modelling studies of mantle dynamics show that in the upper mantle non-Newtonian viscosity may be important. This study explores the non-Newtonian effects on the GIA induced variations in mantle stress and viscosity and on surface observables including vertical displacement, relative sea level (RSL) and gravity change. The recently updated and fully benchmarked software package CitcomSVE is used for GIA simulations. We adopt the ICE-6G ice deglaciation history, VM5a lower mantle and lithospheric viscosities, and a composite rheology that combines Newtonian and non-Newtonian viscosities for the upper mantle. Our results show that: (1) The mantle stress beneath glaciated regions increases significantly during deglaciation, leading to regionally reduced upper mantle viscosity by more than an order of magnitude. Such effects can be rather localized at the periphery of glaciated regions. However, non-Newtonian effects on far-field mantle viscosity are negligibly small. GIA induced stress is also significant in the lithosphere (∼30 MPa) and lower mantle (∼2 MPa). (2) The predicted RSL changes from non-Newtonian models display distinct features in comparison with the Newtonian model, including more rapid sea level falls associated with the rapid deglaciation at ∼14 000 yr ago followed by a more gradual sea level variation for sites near the centres of formerly glaciated regions, and an additional phase of sea level falls for the last ∼8000 yr for sites at the ice margins. Similar time-dependence associated with the deglaciation is also seen for rate of vertical displacement, suggesting a relatively slow present-day rates of vertical displacement and gravity change. These features can be explained by the non-Newtonian effects associated with a loading event which manifest a fast relaxation stage followed by a relative slow relaxation stage. Our results may provide GIA diagnoses for distinguishing non-Newtonian and Newtonian rheology.
The cost-effectiveness of community health workers delivering free diarrhoea treatment: evidence from Uganda
Authors: Wagner Zachary , Zutshi Rushil , Asiimwe John Bosco , Levine David 
Published: October 2021

Abstract
Community health workers (CHWs) are a vital part of the health infrastructure in Uganda and in many other low- and middle-income countries. While the need for CHWs is clear, it is less clear how they should dispense health products to maximize the health benefits to their community. In this study, we assess the cost-effectiveness of several competing CHW distribution strategies in the context of treatment for child diarrhoea. We used data from a four-armed cluster-randomized controlled trial to assess the cost-effectiveness of (1) free distribution of oral rehydration salts (ORS) via home deliveries prior to diarrhoea onset (free delivery arm), (2) free distribution via vouchers where households retrieved the treatment from a central location (voucher arm), (3) a door-to-door sales model (home sales arm) and (4) a control arm where CHWs carried out their activities as normal. We assessed the cost-effectiveness from the implementor’s perspective and a societal perspective in terms of cost per case treated with ORS and cost per disability-adjusted life year (DALY) averted. Free delivery was the most effective strategy and the cheapest from a societal perspective. Although implementor costs were highest in this arm, cost savings comes from households using fewer resources to seek treatment outside the home (transport, doctor fees and treatment costs). From the implementors’ perspective, free delivery costs $2.19 per additional case treated and $56 per DALY averted relative to the control. Free delivery was also extremely cost-effective relative to home sales and vouchers, but there was a large degree of uncertainty around the comparison with vouchers. Free distribution of ORS by CHWs prior to diarrhoea onset is extremely cost-effective compared to other CHW distribution models. Implementers of CHW programmes should consider free home delivery of ORS.
eHEALS as a predictive factor of digital health information seeking behavior among Brazilian undergraduate students
Authors: Lotto Matheus , Maschio Kaiane Fátima , Silva Kimberly Kamila , Ayala Aguirre Patricia Estefania , Cruvinel Agnes , Cruvinel Thiago 
Published: October 2021

Summary
This study aimed to perform the cross-cultural adaptation and validation of the eHealth Literacy Scale (eHEALS) for Brazilian Portuguese. The cross-cultural adaptation was conducted through conceptual equivalence, verbatim translation, semantic, item and operational equivalence, and back-translation. Subsequently, 521 undergraduate students answered the adapted version of the eHEALS, the General Perceived Self-Efficacy Scale (GSES), the Oral Health Impact Profile-14 (OHIP-14) and sociodemographic and health-related questions. Statistical analysis was performed to determine the dimensionality, internal consistency, stability and concurrent/convergent/discriminant/predictive validities of the eHEALS (p &lt; 0.05). The adequacy of sample size was confirmed by a non-identity correlation matrix (Bartlett’s test of sphericity, p &lt; 0.001), without influence of multicollinearity (determinant = 0.026). The confirmatory factor analysis identified four factors in agreement to the constructs namely as online searching self-efficacy, awareness of available sources, information usage ability, and critical analysis of useful information. The eHEALS displayed an excellent internal consistency (Cronbach’s alpha = 0.88), a good stability (ICC = 0.71, 95% CI: 0.49–0.84), and it was significantly correlated with GSES (concurrent validity). Higher eHEALS scores were identified among (i) white and (ii) younger students, (iii) from health sciences courses, (iv) with more years of graduation, (v) who their fathers were working in specialized functions (discriminant validity), and (vi) among those who were frequently interested in digital health information (convergent validity). The students with higher eHealth literacy levels were more likely to seek health information in the last 24 h (predictive validity). In conclusion, the eHEALS demonstrated adequate psychometric properties to be applied for the Brazilian population.
Dexamethasone is a dose-dependent perpetrator of drug–drug interactions: implications for use in people living with HIV
Authors: Jacobs Tom G , Marzolini Catia , Back David J , Burger David M 
Published: October 2021

Abstract
Global use of dexamethasone in COVID-19 patients has revealed a poor understanding of the drug–drug interaction (DDI) potential of dexamethasone, particularly with antiretroviral agents (ARVs). Dexamethasone is both a substrate and a dose-dependent inducer of cytochrome P450 3A4 (CYP3A4). As many ARVs are substrates and/or inhibitors or inducers of CYP3A4, there is concern about DDIs with dexamethasone either as a perpetrator or a victim. Assessment of DDIs that involve dexamethasone is complex as dexamethasone is used at a range of daily doses (generally 0.5 up to 40 mg) and a treatment course can be short, long, or intermittent. Moreover, DDIs with dexamethasone have been evaluated only for a limited number of drugs. Here, we summarize the available in vitro and in vivo data on the interaction potential of dexamethasone and provide recommendations for the management of DDIs with ARVs, considering various dexamethasone dosages and treatment durations.
Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis
Authors: Gastine Silke , Obiero Christina , Kane Zoe , Williams Phoebe , Readman John , Murunga Sheila , Thitiri Johnstone , Ellis Sally , Correia Erika , Nyaoke Borna , Kipper Karin , van den Anker John , Sharland Mike , Berkley James A. , Standing Joseph F. 
Published: October 2021

Abstract

Objectives
This study aimed to simultaneously investigate the pharmacokinetics of ampicillin and gentamicin, currently the WHO standard of care for treating neonatal sepsis.

Methods
Pharmacokinetic data were collected in 59 neonates receiving ampicillin and gentamicin for suspected or proven sepsis in the NeoFosfo trial (NCT03453177). A panel of 23 clinical Escherichia coli isolates from neonates with sepsis, resistant to either ampicillin, gentamicin or both, were tested for susceptibility using chequerboards. Pharmacokinetic/pharmacodynamic (PKPD) modelling and simulations were used to compare single-agent (EUCAST MIC) and combination (chequerboard MIC) target attainment with standard dosing regimens.

Results
A model was established that simultaneously estimated parameters of a one-compartment ampicillin model and a two-compartment gentamicin model. A common clearance for both drugs was used (6.89 L/h/70 kg) relating to glomerular filtration (CLGFR), with an additional clearance term added for ampicillin (5.3 L/h/70 kg). Covariate modelling included a priori allometric weight and post-menstrual age scaling of clearance. Further covariate relationships on renal clearance were postnatal age and serum creatinine.
Simulation-based PKPD assessments suggest good Gram-positive (MIC ≤ 0.25 mg/L) cover. However, less than one-quarter of neonates were predicted to receive efficacious coverage against Enterobacterales (MIC ≤ 2 mg/L). The benefit of the ampicillin/gentamicin combination was limited, with only 2/23 E. coli clinical strains showing FIC index &lt; 0.5 (synergy) and most in the range 0.5–1 (suggesting additivity). Simulations showed that feasible dosing strategies would be insufficient to cover resistant strains.

Conclusions
PKPD simulations showed ampicillin and gentamicin combination therapy was insufficient to cover Enterobacterales, suggesting the need for alternative empirical treatment options for neonatal sepsis.
Bringing the Animal QTLdb and CorrDB into the future: meeting new challenges and providing updated services
Authors: Hu Zhi-Liang , Park Carissa A , Reecy James M 
Published: October 2021

Abstract
The Animal QTLdb (https://www.animalgenome.org/QTLdb) and CorrDB (https://www.animalgenome.org/CorrDB) are unique resources for livestock animal genetics and genomics research which have been used extensively by the international livestock genome research community. This is largely due to the active development of the databases over the years to keep up with the rapid advancement of genome sciences. The ongoing development has ensured that these databases provide researchers not only with continually updated data but also with new web tools to disseminate the data. Through our continued efforts, the databases have evolved from the original Pig QTLdb for cross-experiment QTL data comparisons to an Animal QTLdb hosting 220 401 QTL, SNP association and eQTL data linking phenotype to genotype for 2210 traits. In addition, there are 23 552 correlations for 866 traits and 4273 heritability data on 1069 traits in CorrDB. All these data were curated from 3157 publications that cover seven livestock species. Along with the continued data curation, new species, additional genome builds, and new functions and features have been built into the databases as well. Standardized procedures to support data mapping on multiple species/genome builds and the ability to browse data based on linked ontology terms are highlights of the recent developments.
Impact of Streptococcus pneumoniae Urinary Antigen Testing in Patients With Community-Acquired Pneumonia Admitted Within a Large Academic Health System
Authors: Greenfield Adam , Marsh Kassandra , Siegfried Justin , Zacharioudakis Ioannis , Ahmed Nabeela , Decano Arnold , Aguero-Rosenfeld Maria E , Inglima Kenneth , Papadopoulos John , Dubrovskaya Yanina 
Published: October 2021

Abstract

Background
Limited data support use of pneumococcal urinary antigen testing (PUAT) for patients with community-acquired pneumonia (CAP) as an antimicrobial stewardship tool. At our institution, CAP guidelines and admission order set were standardized to include universal PUAT.

Methods
This was a retrospective study of adults hospitalized in 2019 who had PUAT performed. We compared incidence and timing of de-escalation in PUAT- positive vs -negative groups and described patients’ outcomes.

Results
We evaluated 910 patients, 121 (13.3%) of whom were PUAT positive. No difference in baseline characteristics, including severity of illness, was observed between groups. Initial de-escalation occurred in 82.9% and 81.2% of PUAT-positive and -negative patients, respectively (P = .749). Median time to de-escalation was shorter in the PUAT-positive group (1 [interquartile range {IQR}, 0–2] day vs 1 [IQR, 1–2] day, P = .01). Within 24 hours of PUAT, more patients in the PUAT-positive group had atypical coverage discontinued (61.3% vs 47.2%, P = .026) without difference in methicillin-resistant Staphylococcus aureus (MRSA) agent discontinuation (or antipseudomonal de-escalation). Among the PUAT-positive group, unadjusted analysis demonstrated shorter median length of stay in patients who were de-escalated compared to those who were not (6 [IQR, 4–10] vs 8 [IQR, 7–12] days, P = .0005), without difference in the incidence of Clostridioides difficile, in-hospital mortality, or 30-day infection-related readmission.

Conclusions
We observed earlier de-escalation in the PUAT-positive group. This seems to be due to discontinuation of atypical rather than anti-MRSA or antipseudomonal coverage. Further antimicrobial stewardship interventions are warranted.
The Big Boom Theory: The Common Nighthawk wing-boom display delineates exclusive nesting territories
Authors: Knight Elly C , Brigham R Mark , Bayne Erin M 
Published: October 2021

Abstract
Understanding the functional significance of bird sounds can provide valuable insight into the behavior and how birds use habitat. We show that the Common Nighthawk (Chordeiles minor) wing-boom display is a territorial signal associated with the nest location that can be used to identify territorial habitat use. In other words, the Common Nighthawk wing-boom display can be considered analogous to song due to its potential function in territoriality. We captured, tagged, and tracked 21 male Common Nighthawks in northeastern Alberta to confirm the functional significance of the wing-boom display and describe Common Nighthawk territoriality. Mean wing-boom use density (hereafter “area”) size was 10.2 ha (SD = 11.7 ha). We found minimal overlap in the wing-boom area (5 of 15 neighboring male pairs, 0.2–4.5% overlap), suggesting the wing-boom display represents an exclusive territory. Comparison of wing-boom locations and random points within the wing-boom area confirmed that male Common Nighthawks select areas near the nest to perform wing-boom displays. There was high wing-boom area overlap for the same individual between years. Differences between years reflected shifts in nest location, suggesting that the wing-boom display is a good indicator of the nest location and territory. Future Common Nighthawk surveys should record the type of acoustic signal observed to differentiate territorial habitat use from other functions. Many taxa that produce non-vocal sounds as part of breeding displays could similarly benefit from a functional understanding to provide insight into habitat use.
Genetic and environmental influences on sleep-wake behaviors in adolescence
Authors: O’Callaghan Victoria S , Hansell Narelle K , Guo Wei , Carpenter Joanne S , Shou Haochang , Strike Lachlan T , Crouse Jacob J , McAloney Kerrie , McMahon Katie L , Byrne Enda M , Burns Jane M , Martin Nicholas G , Hickie Ian B , Merikangas Kathleen R , Wright Margaret J 
Published: October 2021

AbstractStudy ObjectivesTo investigate the influence of genetic and environmental factors on sleep-wake behaviors across adolescence.MethodsFour hundred and ninety-five participants (aged 9–17; 55% females), including 93 monozygotic and 117 dizygotic twin pairs, and 75 unmatched twins, wore an accelerometry device and completed a sleep diary for 2 weeks.ResultsIndividual differences in sleep onset, wake time, and sleep midpoint were influenced by both additive genetic (44%–50% of total variance) and shared environmental (31%–42%) factors, with a predominant genetic influence for sleep duration (62%) and restorative sleep (43%). When stratified into younger (aged 9–14) and older (aged 16–17) subsamples, genetic sources were more prominent in older adolescents. The moderate correlation between sleep duration and midpoint (rP = −.43, rG = .54) was attributable to a common genetic source. Sleep-wake behaviors on school and nonschool nights were correlated (rP = .44–.72) and influenced by the same genetic and unique environmental factors. Genetic sources specific to night-type were also identified, for all behaviors except restorative sleep.ConclusionsThere were strong genetic influences on sleep-wake phenotypes, particularly on sleep timing, in adolescence. Moreover, there may be common genetic influences underlying both sleep and circadian rhythms. The differences in sleep-wake behaviors on school and nonschool nights could be attributable to genetic factors involved in reactivity to environmental context.
Divine Warning or Prelude to Secularization? Religion, Politics, and the COVID-19 Pandemic in Turkey
Authors: Altınordu Ateş 
Published: October 2021

Abstract
Religion was a major pillar in the government’s pandemic management and featured centrally in a string of public controversies in the course of the coronavirus crisis in Turkey. This article analyzes the role of Islam in the political and social responses to the COVID-19 pandemic in Turkey, with a focus on four dimensions: (1) religion as a tool of governance, (2) the regulation of collective religious practices, (3) religious interpretations of the pandemic, and (4) predictions about the future impact of the coronavirus crisis on religion. Based on this analysis, the study concludes that the salience and political function of religion in the course of pandemics are contingent upon the place of religious mobilization in the political repertoire of the ruling party and the balance of power between the government and the religious field, respectively. The government's extensive instrumentalization of religion in pandemic management, on the other hand, is likely to give rise to a political backlash against organized religion.
Language, Publication, and the Advancement of Feminist Praxis
Authors: Wentworth Chelsea , Clark Dessie 
Published: October 2021

Abstract
Western voices from publications predominantly in English dominate conversations surrounding knowledge production, consumption, and dissemination, which in turn shapes social policy. To achieve feminist epistemological frameworks that many academic publications espouse, we call for publications that are accessible and equitable not only for academics, but also for community partners and activists. To ensure a role for diverse voices, we must remove language barriers that prioritize Western viewpoints. Feminist scholars are poised to advance the contemporary debates on the politics of the language of academic publishing, and explore ways that a decolonized, inclusive approach could benefit knowledge on a global scale.
I am Chinese: The Politics of Chinese American Lapel Buttons in Los Angeles during World War II
Authors: Gow William 
Published: October 2021

Abstract
This article examines the history of lapel buttons and stickers used by Chinese Americans to identify their ethnicity during World War II. Most of these buttons and stickers were produced by Chinese Consolidated Benevolent Associations (CCBAs) immediately after the attack on Pearl Harbor to differentiate their members from Japanese Americans. In examining this history, this article focuses in particular on Los Angeles, the city with the largest Japanese American population on the West Coast. In Los Angeles, U.S.-born Chinese American and Japanese American youth attended many of the same schools and often formed close friendships with one another. As a result, the questions that the buttons and stickers posed for this generation of Chinese American youth were particularly fraught. Drawing on oral history interviews, sociological studies of the Southern California Chinese American community from the period, and archival newspaper reportage, this article approaches these lapel pins and stickers as items of cultural contestation through which a variety of historical actors—from Chinese consular representatives, to immigrant leaders in the CCBAs, to Chinese American youth—negotiated questions of ethnic and national identity after the U.S. entry into World War II. I argue that rather than reflecting the complex ways that most Chinese American youth understood their own identity, the buttons and stickers represented the official viewpoints of the Chinese consulates in the United States and their allies in the nation’s CCBAs.
CSOG MFM Committee Guideline: Clinical Management Guidelines for Acute Fatty Liver of Pregnancy in China (2021)
Authors: Li Ping , Chen Yaolong , Zhang Weishe , Yang Huixia 
Published: October 2021

Abstract
Acute fatty liver of pregnancy (AFLP) is a rare but critical obstetric-specific disease with a high fatality rate, posing a serious threat to the safety of mothers and infants. These guidelines were specially formulated to standardize AFLP clinical pathways and to improve maternal and infant outcomes. Based on a two-round questionnaire survey, the guideline development team identified the following nine clinical issues that clinicians were most concerned about, and developed recommendations for each of them: prenatal outpatient screening for AFLP, diagnosis, preoperative risk assessment, delivery modes and timing, anesthesia methods, perinatal complications, selecting AFLP patients for artificial liver treatment, prognostic assessment, and monitoring during treatment. The guidelines cover the key issues related to AFLP diagnosis and treatment that concern clinicians.
Psychological distress of healthcare workers in Québec (Canada) during the second and the third pandemic waves
Authors: Carazo Sara , Pelletier Mariève , Talbot Denis , Jauvin Nathalie , De Serres Gaston , Vézina Michel 
Published: October 2021

AbstractObjectiveWe aimed to measure the prevalence of psychological distress among Quebec healthcare workers (HCWs) during the second and third pandemic waves and to assess the effect of psychosocial risk factors (PSRs) on work-related psychological distress among SARS-CoV-2 infected (cases) and non-infected (controls) HCWs.MethodsA self-administered survey was used to measure validated indicators of psychological distress (K6 scale) and PSR (questions based on Karasek and Siegrist models, value conflicts and work-life balance). Adjusted robust Poisson models were used to estimate prevalence ratios.Results4068 cases and 4152 controls completed the survey. Prevalence of high work-related psychological distress was 42%; it was associated with PSRs (mainly work-life balance, value conflicts and high psychological demands) but not with SARS-CoV-2 infection.ConclusionPrimary prevention measures targeting PSRs are needed to reduce mental health risks of HCWs.