bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-17-related signature genes linked to human necrotizing enterocolitis
Authors: Tremblay Éric , Ferretti Emanuela , Babakissa Corentin , Burghardt Karolina Maria , Levy Emile , Beaulieu Jean-François 
Published: March 2021

Abstract
Objective
Necrotizing enterocolitis (NEC) is the most frequent life-threatening gastrointestinal disease experienced by premature infants in neonatal intensive care units all over the world. The objective of the present study was to take advantage of RNA-Seq data from the analysis of intestinal specimens of preterm infants diagnosed with NEC. Function enrichments with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes were used to analyse previous data in order to identify biological and functional processes, which could provide more insight into the pathogenesis of NEC in infants.

Results
Gene set enrichment analysis indicated that the most significant biological pathways over-represented in NEC neonates were closely associated with innate immune functions. One of the striking observations was the highly modulated expression of inflammatory genes related to the IL-17 pathway including such as pro-inflammatory cytokines (CXCL8), chemokines (CXCL5 and CXCL10) and antimicrobials (DEF5A, DEF6A, LCN2, NOS2) in the intestine of neonates diagnosed with NEC. Interestingly, the increase in IL-17 expression appeared to be under the IL-17F form, as reported in Crohn's disease, another inflammatory bowel disease. Further investigation is thus still needed to determine the precise role of IL-17F and its downstream targets in NEC.
Organoids in domestic animals: with which stem cells?
Authors: Pain Bertrand 
Published: March 2021

AbstractOrganoids are three-dimensional structures that are derived from the self-organization of stem cells as they differentiate in vitro. The plasticity of stem cells is one of the major criteria for generating organoids most similar to the tissue structures they intend to mimic. Stem cells are cells with unique properties of self-renewal and differentiation. Depending on their origin, a distinction is made between pluripotent (embryonic) stem cells (PSCs), adult (or tissue) stem cells (ASCs), and those obtained by somatic reprogramming, so-called induced pluripotent stem cells (iPSCs). While most data since the 1980s have been acquired in the mouse model, and then from the late 1990s in humans, the process of somatic reprogammation has revolutionized the field of stem cell research. For domestic animals, numerous attempts have been made to obtain PSCs and iPSCs, an approach that makes it possible to omit the use of embryos to derive the cells. Even if the plasticity of the cells obtained is not always optimal, the recent progress in obtaining reprogrammed cells is encouraging. Along with PSCs and iPSCs, many organoid derivations in animal species are currently obtained from ASCs. In this study, we present state-of-the-art stem cell research according to their origins in the various animal models developed.
Zinc is an important inter-kingdom signal between the host and microbe
Authors: Xia Pengpeng , Lian Siqi , Wu Yunping , Yan Li , Quan Guomei , Zhu Guoqiang 
Published: March 2021

AbstractZinc (Zn) is an essential trace element in living organisms and plays a vital role in the regulation of both microbial virulence and host immune responses. A growing number of studies have shown that zinc deficiency or the internal Zn concentration does not meet the needs of animals and microbes, leading to an imbalance in zinc homeostasis and intracellular signalling pathway dysregulation. Competition for zinc ions (Zn2+) between microbes and the host exists in the use of Zn2+ to maintain cell structure and physiological functions. It also affects the interplay between microbial virulence factors and their specific receptors in the host. This review will focus on the role of Zn in the crosstalk between the host and microbe, especially for changes in microbial pathogenesis and nociceptive neuron-immune interactions, as it may lead to new ways to prevent or treat microbial infections.
n-Expansively super-homogeneous and $(n,k)$-contractively sub-homogeneous fuzzy control functions and stability results with numerical examples
Authors: Saadati Reza , Park Choonkil , O’Regan Donal , Nadaban Sorin 
Published: March 2021

AbstractWe consider fuzzy sets and generalized triangular norms on positive elements of order commutative $C^{*}$

C
∗

-algebras to study the concept of $C^{*}$

C
∗

-algebra valued normed algebras with uncertainty. Using n-expansively super-homogeneous and $(n,k)$
(
n
,
k
)
-contractively sub-homogeneous control functions, we make stochastic $(\Theta,\Upsilon,\Xi )$
(
Θ
,
ϒ
,
Ξ
)
-derivations stable and get a better estimated error. We present some numerical examples of control functions and approximations to illustrate the applicability of the main results.
Existence of positive solutions for a class of fractional differential equations with the derivative term via a new fixed point theorem
Authors: Sang Yanbin , He Luxuan , Wang Yanling , Ren Yaqi , Shi Na 
Published: March 2021

AbstractIn this paper, we firstly establish the existence and uniqueness of solutions of the operator equation $A(x,x)+ B(x,x)+C(x)+e = x$
A
(
x
,
x
)
+
B
(
x
,
x
)
+
C
(
x
)
+
e
=
x
, where A and B are two mixed monotone operators, C is a decreasing operator, and $e\in P$
e
∈
P
with $\theta \leq e \leq h$
θ
≤
e
≤
h
. Then, using our abstract theorem, we prove a class of fractional boundary value problems with the derivative term to have a unique solution and construct the corresponding iterative sequences to approximate the unique solution.
Diversity roles of CHD1L in normal cell function and tumorigenesis
Authors: Xiong Xifeng , Lai Xudong , Li Aiguo , Liu Zhihe , Ma Ningfang 
Published: March 2021

AbstractChromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and development. CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcriptional regulation through its bindings to DNA. By regulating kinds of complex networks, CHD1L has been identified as a potent anti-apoptotic and pro-proliferative factor. CHD1L is also an oncoprotein since its overexpression leads to dysregulation of related downstream targets in various cancers. The latest advances in the functional molecular basis of CHD1L in normal cells will be described in this review. As the same time, we will describe the current understanding of CHD1L in terms of structure, characteristics, function and the molecular mechanisms underlying CHD1L in tumorigenesis. We inference that the role of CHD1L which involve in multiple cellular processes and oncogenesis is well worth further studying in basic biology and clinical relevance.
Heterologous immunoassay strategy for enhancing detection sensitivity of banned dye rhodamine B in fraudulent food
Authors: Wang Jin , Shen Xing , Zhong Peng , Li Zhaodong , Tang Qiushi , Huang Xinan , Zherdev Anatoly V. , Dzantiev Boris B. , Eremin Sergei A. , Xiao Zhili , Lei Hongtao , Li Xiangmei 
Published: March 2021

Abstract
Background
The high quality of antibody (Ab) is critical for an immunoassay; usually, an Ab with low affinity is often regarded as a “bad” one in the immunoassay development. How to use a “bad” Ab to develop a highly sensitive immunoassay is still a huge challenge.

Methods
In this study, a heterologous immunoassay strategy was designed to enhance the sensitivity for the detection of banned dye, rhodamine B (RB), in fraudulent food. The RB Ab could not recognize RB by pairing with homologous coating antigen (Ag). However, the Ab showed unexpected high specificity and sensitivity recognition after being replaced by heterologous coating Ag. Indirect competitive enzyme-linked immunosorbent assay (icELISA) was developed based on the heterologous strategy.

Results
The detection limit of icELISA for chilli powder, Chinese prickly ash, hot-pot seasoning, and chilli sauce was 0.002 μg/kg, and the recoveries of the four samples ranged from 76.0 to 102.0%, with the coefficient of variation between 3.9 and 18.8%. Parallel experiment for 20 market samples with high-performance liquid chromatography (HPLC) was performed on to confirm the performance of the practical application of the developed icELISA, and the results of the two methods had good correlation. Molecular modeling inferred that the carboxyl group of hapten and its exposure level played an important role in the hapten-Ab recognition.

Conclusions
The proposed icELISA can be used for the surveillance screening of RB in a range of seasoning foods, and the heterologous strategy is an effective approach to enhance the sensitivity in an immunoassay.
Factors associated with 1-year visual response following intravitreal bevacizumab treatment for diabetic macular edema: a retrospective single center study
Authors: Choovuthayakorn Janejit , Tantraworasin Apichat , Phinyo Phichayut , Patumanond Jayanton , Kunavisarut Paradee , Srisomboon Titipol , Winaikosol Pawara , Patikulsila Direk , Chaikitmongkol Voraporn , Watanachai Nawat , Pathanapitoon Kessara 
Published: March 2021

AbstractBackgroundTo explore the association of clinical characteristics and retinal microstructural features on optical coherence tomography in predicting 1-year visual response following intravitreal bevacizumab injections in eyes with visual impairment from center-involved diabetic macular edema (CI-DME).MethodsMedical records of patients with visual impairment from CI-DME, who initiated intravitreal bevacizumab injections between Jan 2012 and Dec 2016 and were followed for a minimum of 12 months were retrospectively reviewed.ResultsThe study included 226 eyes with a mean (SD) baseline visual acuity (VA) of 51.8 (19.1) letters. At week 12, following the three initial treatments, a mean (SD) VA improved to 61.7 (17.8) letters. Visual gain ≥ 10 letters was observed in 109 eyes (48.2%), while a limited early visual gain < 5 letters was noted in 80 eyes (35.4%). At one year, 110 eyes (48.7%) achieved a good VA gain ≥ 10 letters. In addition, eyes with poor baseline VA had a higher proportion of eyes that obtained limited early VA gained at week 12 (< 5 letters) and maintained in this visual response category at moth 12 compared to eyes with better baseline VA (74.1% versus 59.1%). In the multivariable logistic regression, the following factors reduced the probability of 1-year visual gain ≥ 10 letters: elderly (p = 0.040), better baseline vision (p = 0.001), and limited early visual gain < 5 letters at week 12 (p < 0.001). In multivariable linear regression, male (p = 0.010) and eyes with the presence of hyperreflective foci on baseline OCT (p = 0.010) were likely to have higher VA improvement. However, eyes with better baseline VA (p = 0.002), limited early VA gain at week 12 (p < 0.001), and a presence of EZ disruption at week 12 (p = 0.002) were likely to have less VA improvement.ConclusionsAlthough bevacizumab is considered as effective management for CI-DME, variability in treatment responses is expected. This study revealed that baseline characteristics and visual responses at week 12 might help predict the long-term treatment response. Eyes with characteristics at risk of limited long-term visual outcome may require attention in optimizing their individual treatment strategies.
Clinical management of an outbreak of nutritionally variant streptococcus endophthalmitis following intravitreal bevacizumab injection
Authors: Barnes Alexander C. , Rathbun Stephen L. , Kuthyar Sanjana , Hubbard G. Baker , Bergstrom Chris , Yeh Steven , Iyer Mohan N. 
Published: March 2021

Abstract
Background
The management of an outbreak of endophthalmitis associated with intravitreal bevacizumab represents a challenging real-time process involving identification of cases, treatment and mitigation measures during the outbreak. We summarize the clinical presentation and management of a cluster of endophthalmitis cases from contaminated bevacizumab, in addition to mathematical probabilistic assessment of the number of cases that define an outbreak.

Methods
A retrospective study was conducted to assess the management of an endophthalmitis outbreak after intravitreal bevacizumab (IVB) administration. Demographic data, clinical information, individual patient management and public health reporting measures were reviewed. Outcomes of patients who received prophylactic antibiotics for endophthalmitis prevention were also reviewed. Binomial tail probability calculations were performed to determine the likelihood of clusters of endophthalmitis that could inform when an outbreak was evolving that would warrant more public health notification measures and communication.

Results
Forty-five eyes of 42 patients who received IVB from a single batch were reviewed. Four cases of endophthalmitis from Granulicatella adiacens, a nutritionally-variant Streptococcus species, were treated successfully with intravitreal antibiotics ± vitrectomy. Thirty-four of the remaining 41 eyes were treated with prophylactic intravitreal vancomycin with no additional cases of endophthalmitis. Outbreak management also included CDC, ASRS and public health authority notification. Binominal tail probabilities demonstrated the rarity of clusters from a single batch (i.e. ~ 1/10,000 for 2 cases; 1/2 million for 3 cases). However, given the U.S. scale of IVB administration, there is an 87% chance of a cluster ≧ 2 and a 1% chance of a cluster ≧ 3 cases annually, which may guide outbreak management. A process diagram was developed to incorporate patient management and public health measures when an outbreak is suspected.

Conclusion
Intravitreal antibiotics and vitrectomy were effective in the individual management of cases of endophthalmitis, and no serious adverse events occurred with prophylactic intravitreal vancomycin for at-risk eyes. Best practices for outbreaks should be evaluated, given their likelihood within the U.S. and the sight-threatening consequences of endophthalmitis.
Spectrum of atypical pulmonary manifestations of COVID-19 on computed tomography
Authors: Gurumurthy Balasubramanian , Das Sudha Kiran , Hiremath Rudresh , Shetty Sachin , Hiremath Aniketh , Gowda Thasmai 
Published: March 2021

Abstract
Background
The typical CT manifestations of COVID-19 pneumonia include ground-glass opacity (GGO) with or without consolidation and superimposed interlobular septal thickening. These are often rounded in morphology and frequently bilateral, multilobar, posterior, peripheral, and basilar in distribution. The various atypical CT features of COVID-19 are seldom described in the literature. The study aims to enumerate the atypical pulmonary CT features in patients with COVID-19 pneumonia in correlation with the disease severity.

Results
A total of 298 confirmed cases of COVID-19 pneumonia with positive reverse transcription polymerase chain reaction (RT-PCR) who underwent chest CT scans were retrospectively evaluated. The cohort included 234 (78.5%) men and 64 (21.5%) women and the mean age was 53.48 ± 15.74 years. The most common presenting symptoms were fever [n = 197 (66.1%)] and cough [n = 139 (46.6%)]. Out of 298 cases of COVID-19 pneumonia, 218 cases (73.1%) showed typical CT features while 63 cases (21.1%) showed atypical CT features with concurrent classical findings and the remaining 17 cases (5.8%) were normal. Among the atypical CT features, the most common was pulmonary cysts [n = 27 (9%)]. The other features in the order of frequency included pleural effusion [n = 17 (5.7%)], nodules [n = 13 (4.3%)], bull’s eye/target sign[n = 4 (1.3%)], cavitation [n = 3 (1.0%)], spontaneous pneumothorax [n = 2 (0.6%)], hilar lymphadenopathy [n = 2 (0.6%)], spontaneous pneumo-mediastinum with subcutaneous emphysema [n = 1 (0.3%)], Halo sign [n = 1 (0.3%)], empyema [n = 1 (0.3%)] and necrotizing pneumonia with abscess [n = 1 (0.3%)].

Conclusion
CT imaging features of COVID-19 pneumonia while in a vast majority of cases is classical, atypical diverse patterns are also encountered. A comprehensive knowledge of various atypical presentations on imaging plays an important role in the early diagnosis and management of COVID-19.
Cold-atmospheric-plasma–induced skin wrinkle
Authors: Zheng Hui , Chen Peijian , Chen Zhitong 
Published: March 2021

Abstract
The biomedical applications of cold atmospheric plasma (CAP) involve diverse multidisciplinary approaches and are based on the plasma interactions with tissues/cells and other biomaterials. Recently, we have implemented experiments for plasma-tissue interactions and first observe CAP-induced skin wrinkling behavior. The plasma-induced wrinkling behavior during the CAP interaction with a mouse's skin is explored through theoretical modeling and numerical simulation. It is found that the critical strain decreases with the increase of the elastic modulus ratio of the equivalent film-substrate model. The change of the elastic modulus ratio will lead to different surface morphology, which infers a suitable way to diagnose skin diseases. In addition, surface morphologies with similar wavelength but larger amplitude can be observed for a larger radius of curvature. These results might help the plasma community to understand the CAP-induced wrinkling phenomenon and stimulate extensive discussions on studies on plasma-tissue/biomaterials interactions.
ЦИФРОВАЯ ТРАНСФОРМАЦИЯ БИЗНЕС-ПРОЦЕССОВ КОММЕРЧЕСКИХ БАНКОВ ПОД ВЛИЯНИЕМ ТЕХНОЛОГИЙ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА
Authors: Tereshchenko Sergei Nikolaevich 
Published: March 2021

Технологии искусственного интеллекта сегодня являются сквозными технологиями цифровой трансформации субъектов экономической деятельности, в том числе и банковского сектора. Коммерческие банки, за последнее десятилетие, прошли существенный путь трансформации от классических банков с филиальной сетью с менеджерско-кассирским обслуживанием до практически полного превращения банка в онлайн-сервис с обработкой многих функций интеллектуальным агентом без участия человека. Банковский сектор стал одним из драйверов внедрения систем искусственного интеллекта. Для оценки ключевых этапов цифровой трансформации банковского сектора в мире можно использовать анализ крупнейших мировых соревнований по программированию и прикладному применению технологий искусственного интеллекта для задач банковской отрасли.В статье рассматриваются технологические подходы по решению ключевых задач банковского дела в международных соревнованиях по программированию. Результаты соревнований анализируются как срез текущего запроса на технологии от банковского сектора и показатели уровня развития технологий искусственного интеллекта.Цель – исследование хода проведения и результатов международных соревнований по применению технологий искусственного интеллекта в задачах банковского дела как метрики цифровой трансформации бизнес-процессов банковского сектора.Метод или методология проведения работы: в статье использовались приемы и инструменты системного анализа и обобщения.Результаты: выявлены ключевые этапы цифровой трансформации бизнес-процессов банковского сектора за период 2010–2020 гг. и определен вектор развития технологий банковского дела.Область применения результатов: полученные результаты целесообразно применять субъектами банковского сектора для выстраивания стратегии цифровой трансформации бизнес-процессов.
Net-Metered Distributed Renewable Energy: A Peril for Utilities?
Authors: Sunar Nur , Swaminathan Jayashankar M. 
Published: March 2021

Electricity end-users have been increasingly generating their own electricity via rooftop solar panels. We study the impact of such distributed renewable energy (DRE) on utility profits and social welfare under net metering, which is a widespread policy in the United States. Utilities have been lobbying against net-metered distributed solar based on the common belief that it harms utility profits. We find that when wholesale market dynamics are considered, net-metered DRE may be a positive for utilities. That is, net-metered DRE strictly improves the expected utility profit when the utility’s self-supply is below a threshold and the wholesale electricity price is sufficiently responsive to wholesale demand fluctuations. Our paper distinctively considers both downstream and upstream impacts of net-metered DRE on utilities and analyzes the tradeoff between these impacts. Net-metered DRE can increase utilities’ expenses because of their required buyback from generating customers, and reduces their retail sales revenues. In addition, it can either reduce utilities’ wholesale procurement costs or affect their wholesale market revenues. Our results suggest that utilities might benefit from emerging business strategies that motivate their customers to install solar panels. Our numerical study uses data on the distributed solar in California and the wholesale electricity market operated by the California Independent System Operator, and demonstrates that our findings hold under realistic parameters. This paper was accepted by David Simchi-Levi, operations management.
PENGARUH PENDIDIKAN ANAK USIA DINI TERHADAP PERKEMBANGAN KONDISI SOSIAL-EMOSI ANAK USIA PRASEKOLAH
Authors: Asmarita Asmarita , Hamid Abdurrahman , Utami Agnita 
Published: March 2021

The social and emotional development of young children is affected by many stimulating factors, and one of those factors is early childhood education. However, not all pre-school children have the opportunity to attend early childhood education. This study was aimed at comparing children’s social and emotional development of those who attend and do not attend early childhood education. This comparative study was carried out using a cross-sectional approach among 72 participants divided into 2 groups: 36 participants who attend early childhood education and 36 participants who do not attend early childhood education. Accidental sampling technique was applied to select samples, Non-parametric statistical test employed was the Mann Whitney test. Comparison value of children attending and not attending early childhood education was P-value 0.000; the emotional comparison value was P-value 0.040. It means there were differences in social and emotional development between children who attend early childhood education and those who do not attend early childhood education. It can be concluded that early childhood education can help stimulate the development of children. Parents should pay more attention to their children’s social and emotional development, whereas if parents cannot be the medium to support children’s social and emotional development, they should engage their children to early childhood education.
Experimental and theoretical study of adsorption of L-cysteine on the passivation and corrosion inhibition of aluminum alloy in alkaline environment
Authors: Kharacha Said , Belkhaouda M’hamed , Bammou Lahcen , Batah Ahmed , Bazzi Ilyasse , Salghi Rachid , El Issami Souad , Hilali Mustapha 
Published: March 2021

<p class="Default">L-Cysteine (L-Cyst) was tested as a corrosion inhibitor of 3003 aluminum alloy (AA3003) in Na<sub>2</sub>CO<sub>3</sub> 0.1M + NaCl 1M solution. The inhibition action of this inhibitor was studied by using electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP), and cyclic voltammetry (CV) techniques. The temperature effect on the inhibition efficiency was studied in the range from 298 to 328K, and the values of activation thermodynamic parameters were calculated and explained. Experiment results show that inhibition efficiency increases with the increase of L-Cysteine concentration, and its inhibition efﬁciency reaches 92% at 10<sup>−3</sup>M. The inhibition efficiency decreases slightly with the elevation of a corrosive medium temperature. Analysis of the polarization curves revealed that L-Cyst is considered a mixed inhibitor. The results from electrochemical measurements and theoretical calculations are in good agreement. The morphological changes of the surface during corrosion, in the presence and absence of the inhibitor, were studied by scanning electron microscopy (SEM).</p>