bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal
Authors: Tanimoto Keiji , Hirota Kiichi , Fukazawa Takahiro , Matsuo Yoshiyuki , Nomura Toshihito , Tanuza Nazmul , Hirohashi Nobuyuki , Bono Hidemasa , Sakaguchi Takemasa 
Published: August 2021

AbstractSince understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2. Although cigarette smoke is generally believed to be harmful to the pathogenesis of COVID-19, cigarette smoke extract (CSE) treatments were surprisingly found to suppress the expression of ACE2 in HepG2 cells. We thus tried to clarify the mechanism of CSE effects on expression of ACE2 in mammalian cells. Because RNA-seq analysis suggested that suppressive effects on ACE2 might be inversely correlated with induction of the genes regulated by aryl hydrocarbon receptor (AHR), the AHR agonists 6-formylindolo(3,2-b)carbazole (FICZ) and omeprazole (OMP) were tested to assess whether those treatments affected ACE2 expression. Both FICZ and OMP clearly suppressed ACE2 expression in a dose-dependent manner along with inducing CYP1A1. Knock-down experiments indicated a reduction of ACE2 by FICZ treatment in an AHR-dependent manner. Finally, treatments of AHR agonists inhibited SARS-CoV-2 infection into Vero E6 cells as determined with immunoblotting analyses detecting SARS-CoV-2 specific nucleocapsid protein. We here demonstrate that treatment with AHR agonists, including FICZ, and OMP, decreases expression of ACE2 via AHR activation, resulting in suppression of SARS-CoV-2 infection in mammalian cells.
SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells
Authors: Kumar Parameet , Soni Dharmendra Kumar , Sen Chaitali , Larsen Mads B. , Mazan-Mamczarz Krystyna , Piao Yulan , De Supriyo , Gorospe Myriam , Frizzell Raymond A. , Biswas Roopa 
Published: August 2021

AbstractCystic fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking. Here, we investigated the role of SFPQ in the regulation of the expression and function of F508del-CFTR in CF lung epithelial cells. We find that the expression of SFPQ is reduced in F508del-CFTR CF epithelial cells compared to WT-CFTR control cells. Interestingly, the overexpression of SFPQ in CF cells increases the expression as well as rescues the function of F508del-CFTR. Further, comprehensive transcriptome analyses indicate that SFPQ plays a key role in activating the mutant F508del-CFTR by modulating several cellular signaling pathways. This is the first report on the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung disease. Our findings provide new insights into SFPQ-mediated molecular mechanisms and point to possible novel epigenetic therapeutic targets for CF and related pulmonary diseases.
Transcriptomic analysis of the mouse retina after acute and chronic normobaric and hypobaric hypoxia
Authors: Ebner L. J. A. , Samardzija M. , Storti F. , Todorova V. , Karademir D. , Behr J. , Simpson F. , Thiersch M. , Grimm C. 
Published: August 2021

AbstractOxygen delivery to the retinal pigment epithelium and the outer retina is essential for metabolism, function, and survival of photoreceptors. Chronically reduced oxygen supply leads to retinal pathologies in patients and causes age-dependent retinal degeneration in mice. Hypoxia can result from decreased levels of inspired oxygen (normobaric hypoxia) or reduced barometric pressure (hypobaric hypoxia). Since the response of retinal cells to chronic normobaric or hypobaric hypoxia is mostly unknown, we examined the effect of six hypoxic conditions on the retinal transcriptome and photoreceptor morphology. Mice were exposed to short- and long-term normobaric hypoxia at 400 m or hypobaric hypoxia at 3450 m above sea level. Longitudinal studies over 11 weeks in normobaric hypoxia revealed four classes of genes that adapted differentially to the hypoxic condition. Seventeen genes were specifically regulated in hypobaric hypoxia and may affect the structural integrity of the retina, resulting in the shortening of photoreceptor segment length detected in various hypoxic groups. This study shows that retinal cells have the capacity to adapt to long-term hypoxia and that consequences of hypobaric hypoxia differ from those of normobaric hypoxia. Our datasets can be used as references to validate and compare retinal disease models associated with hypoxia.
Predation risk is a function of seasonality rather than habitat complexity in a tropical semiarid forest
Authors: Ferreira Anthony Santana , Faria Renato Gomes 
Published: August 2021

AbstractPredator–prey dynamics are some of the most important species’ interactions in the natural structuring of communities, and are among the more complex ecological processes studied by ecologists. We measured predation risk using artificial lizard replicas to test two competing hypotheses regarding predation pressure in semi-arid environments: (1) predation risk is dependent on the habitat structural complexity; and (2) predation risk is dependent on seasonality. We placed 960 lizard replicas along three sites with different physical structures and in both dry and rainy seasons for seven consecutive days in a caatinga area in northeastern Brazil at Grota do Angico Natural Monument (GANM). Birds were responsible for the majority of attacks and more frequently on artificial lizards placed in trees. Attacks focused on the most vulnerable areas of the body (head and torso), proving that were perceived by predators as true prey items. We found that predation risk is not dependent on the habitat structural complexity, but rather dependent on the caatinga seasonality, with the overall attack rate being 19% higher in the dry season. Our study suggests that potential predation risk is highly context-dependent and that seasonality consistently drives of trophic interactions strength in the caatinga, an important ecological finding that could contribute to better understanding the complex evolution of predator–prey interactions within communities of animals living in different habitats.
The detection of Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and their application to live-cell imaging
Authors: Song In-ho , Torawane Pritam , Lee Jung-Seop , Warkad Shrikant Dashrath , Borase Amulrao , Sahoo Suban K. , Nimse Satish Balasaheb , Kuwar Anil 
Published: August 2021

The quick response, easy-synthesis, and high sensitivity make receptor 3 an ideal sensor for detecting Al3+ ions in a semi-aqueous medium and living cells.
FeCO3 as a novel precursor for controllable synthesis of monodisperse iron oxide nanoparticles via solution thermal decomposition
Authors: Wang Guorong , Cui Mengyao , Qiu Ying , Miao Yuqing , Ma Huijun , Zhang Huan , Zhang Yifan , Liu Xiaoli , Yi Jiabao , Peng Mingli , Fan Haiming 
Published: August 2021

AbstractThermal decomposition in solution is the most effective approach for achieving highly monodisperse iron oxide nanoparticles (IONPs). However, a simple, economical, and environment‐friendly iron precursor with high iron content remains in great demand. Although siderite (FeCO3) has been reported to produce iron oxide particles via calcination, it is difficult to control the shapes of the obtained particles compared to those obtained by solution methods. Herein, FeCO3 was employed as a precursor in solution thermal decomposition to prepare monodisperse IONPs and investigated the influence of reaction conditions on the particle size, including the concentration of oleic acid, concentration of the precursor, and the reaction temperature. The seed‐mediated growth method with FeCO3 as a precursor was also studied to extend the scope of particle size. The experimental results demonstrate that high‐quality IONPs can be synthesized in solution via FeCO3 thermal decomposition. The particle diameter was tuned between 3 and 20 nm by varying the reaction conditions, and by seed‐mediated growth. FeCO3 is thus a readily available, economical, environment‐friendly precursor with high iron content, which is a novel candidate for the synthesis of IONPs.
Its Not about the Destination, Its about the Journey—Plotting 50 Years of Changing Clinical Trends in Plastic Surgery in a Public Sector Teaching Hospital
Authors: Rajan Sheeja , Menedal Akshata , Pereira Carlsen , Chandran Aswathy , Bhaskaran Deepak , Mohammad Najeeb , Thomas Bestin , Sulochana Aabha Das 
Published: August 2021

AbstractBackground The year 2019 marked the 50th anniversary of plastic surgery department of our institution. We present an audit to plot the changing clinical trends in our work in the past five decades.Methods A single-center retrospective cohort study based on the department demographics was performed and compared across the decades from 1969 to 2019.Results In 1969, the relative proportion of reconstructive versus cosmetic surgery procedures was 94.32% versus 5.68%; in 2019 this was 76.25% and 23.75%, respectively. An increase of 22 times increase in outpatient registrations, 13.1 times in total surgeries, 642 times in trauma reconstruction, 290 times for hand surgeries, and 323 times for skin tumor surgeries was noted. Male patients (64.9%) increased every decade more than females (35.1%), mostly for trauma surgery and gynecomastia correction. Proportion of pediatric cleft patients have markedly decreased. Spectrum of surgical procedures have widened. Top five reconstructive surgeries in 2019 were limb trauma reconstruction, skin tumor surgeries, hand surgeries, arterio-venous fistula (AV) creation, and oculoplasty. The most common surgery performed was cleft lip surgery in 1969 and hand surgery in 2019. The top five cosmetic surgeries performed in 2019 were scar revisions, nevus excision, liposuction and gynecomastia correction, rhinoplasty, and otoplasty.Conclusions Data collection and archiving and periodic audits help us study changing trends in our field compared with the global trends. Knowing societal demands will help to improve the resident training in teaching hospitals.
Use of the Vertical Profunda Artery Perforator Flap to Capture the Dominant Perforator: A Cadaver Dissection and Imaging Study
Authors: Artz Jourdain D. , Atamian Elisa K. , Mulloy Clairissa , Stalder Mark W. , Zampell Jamie , Hilaire Hugo St. 
Published: August 2021

Abstract
Background While the originally described transverse profunda artery perforator (tPAP) flap is designed to capture the first profunda perforator, our group hypothesized the dominant perforator may not always be captured in this configuration. This study maps the location of dominant profunda perforators using imaging and cadaveric dissections to determine the probability of capturing dominant perforators with the transverse flap design versus the vertical PAP (vPAP) variant.
Methods Fifty preoperative magnetic resonance angiogram or computed tomographic angiogram scans (100 total extremities) were examined from autologous breast reconstruction patients between 2015 and 2019. Profunda perforator characteristics that were examined included the distance from the pubic tubercle to the infragluteal fold (IGF), the distance of the perforators from the IGF, distance posterior to the gracilis, the diameter of the perforator at fascial exit, and total number of perforators present. Profunda perforator dissection was performed in 18 cadaveric extremities. Analysis included mean distance from pubic tubercle, distance posterior to the gracilis, diameter at fascial exit, and total number of perforators.
Results In imaging analysis, the mean distance from the IGF to the fascial exit of all dominant perforators was 7.04 cm. The mean diameter of the dominant perforator at the fascial exit was 2.61 mm. Twenty-six thighs (26%) demonstrated dominant perforators that exited the fascia greater than 8 cm below the IGF. In cadaver dissections, the mean distance from the pubic tubercle to the fascial exit of all the dominant perforators was 10.17 cm. Nine cadaver specimens (50%) demonstrated perforators that exited the fascia greater than 8 cm below the estimated IGF.
Conclusion The dominant perforator can often be missed in the traditional tPAP design. The vPAP incorporates multiple perforators with a long pedicle, excellent vessel diameter, and favorable donor-site.
Evaluation of CBC Parameters in Relation to PCR Test Results in Diagnosing Pediatric COVID-19 Disease
Authors: Bagci Zafer , Ugur Ayşe Ruveyda , Ugur Cüneyt 
Published: August 2021

AbstractObjective This study aimed to investigate whether complete blood count parameters have predictive properties in diagnosing coronavirus disease 2019 (COVID-19) in regard to positive polymerase chain reaction (PCR) test in children with a prediagnosis of COVID-19, and whether these parameters are related to the severity of clinical findings in children with COVID-19.Methods This retrospective cross-sectional study included children who were hospitalized with a possible diagnosis of COVID-19 and had undergone PCR testing in the COVID-19 children's clinic. Probable case definition was made according to the COVID-19 diagnostic and therapeutic guidelines of the Ministry of Health of the Republic of Turkey.Results A total of 133 patients were included in the study, of which 46 (34.6%) were negative for the PCR test and 87 (65.4%) were positive for the PCR test. white blood cell (WBC), neutrophil, lymphocyte, and platelet levels were significantly lower in the PCR positive group than in the PCR negative group. The platelet to mean platelet volume ratio (PLT/MPV) was significantly lower in the PCR positive group than the PCR negative group, whereas the platelet distribution width (PDW) of the PCR positive patient group was significantly higher than the PCR negative group. For the multivariable model with PDW and neutrophil to lymphocyte ratio/age factors included, F1 score was 0.864, area under the receiver operating characteristics was 0.804, and area under the precision-recall curve was 0.873. The decision tree had a 72.9% cross-validation accuracy value.Conclusion WBC, neutrophils, lymphocytes, platelets, PLT/MPV, and PDW parameters could be used in conjunction with clinical symptoms and findings to predict the PCR test result.
High amplification laser-pressure optic enables ultra-low uncertainty measurements of optical laser power at kilowatt levels
Authors: Artusio-Glimpse Alexandra B , Rogers Kyle A , Williams Paul A , Lehman John H 
Published: August 2021

Abstract
We present the first measurements of kilowatt laser power with an uncertainty less than 1%. These represent progress toward the most accurate measurements of laser power above 1 kW at 1070 nm wavelength and establish a more precise link between force metrology and laser power metrology. Radiation pressure, or photon momentum, is a relatively new method of non-destructively measuring laser power. We demonstrate how a multiple reflection optical system amplifies the pressure of a kilowatt class laser incoherently to improve the signal to noise ratio in a radiation pressure-based measurement. With 14 incoherent reflections of the laser, we measure a total uncertainty of 0.26% for an input power of 10 kW and 0.46% for an input power of 1 kW at the 95% confidence level. These measurements of absolute power are traceable to the SI kilogram and mark a state-of-the-art improvement in measurement precision by a factor of four.
An efficient hybrid conjugate gradient method with descent properties under strong Wolfe line search
Authors: Sulaiman I M , Mamat M , Hassan Basim A. , Ghazali P L , Ahmad M Z 
Published: August 2021

AbstractThe hybrid conjugate gradient parameters are among the efficient variants of conjugate gradient (CG) methods for solving large-scale unconstrained optimization problems. This is due to their nice convergence properties and low memory requirements. In this paper, we present a new hybrid conjugate gradient method based on famous CG algorithms for large-scale unconstrained optimization. The proposed hybrid CG method can generate a descent search direction at each iteration provided the strong Wolfe line search is employed. Numerical results have been presented which show that the proposed method is efficient and promising.
Modified higher order block backward differentiation formula for third order ordinary differential equations
Authors: Asnor A I , Yatim S A M , Ibrahim Z B 
Published: August 2021

Abstract
This study is aimed to modify higher order block backward differentiation formulae for dealing with the third order stiff ordinary differential equations (ODEs). Two new solutions are acquired at each step by using a few back values in preceding blocks. Apart from that, the differentiation coefficients will be stored, thus, repetitive calculations of the coefficients can be avoided as well as computational cost can also be optimized. A comparative analysis will be presented once the numerical experiments have been conducted to a few considered problems in order to confirm the efficiency of the proposed method with the existing stiff ODE solver. The analysis proves the accuracy and efficiency of the proposed method can be served as another alternative for third order stiff ODEs.
Modeling Fuzzy B-spline Interpolation Series using α-cut operation for spatial earth surface problem
Authors: Abu Bakar N A , Yusoff B , Wahab A F , Mamat M 
Published: August 2021

Abstract
In this paper, the series of α-cut is also known as the α-cut operation used to construct a new model of surface called Fuzzy B-spline Interpolation Series surface. The surface is called Fuzzy B-spline Interpolation Series because of the various values of α chosen in the fuzzification method. Then, the operation is combined into a B-spline surface model. This new proposed model will be used to solve spatial earth surface problems in every collected data points. The spatial earth data have values in latitude, longitude and altitude. All these values are considered as uncertainty data because of the satellite’s measurement errors. Finally, constructed surfaces’ results will be compared between raw data’s surface and Fuzzy B-spline Interpolation Series surface.
First order polarization tensor approximation using multivariate polynomial interpolation method via least square minimization technique
Authors: Sukri Suzarina Ahmed , Hoe Yeak Su , Khairuddin Taufiq Khairi Ahmad 
Published: August 2021

AbstractThis paper proposes a new numerical approach useful in dealing with nearly singular integrals, specifically, the integral of the first order polarization tensor (PT). Polarization tensor represents the integral equations in an asymptotic series, and it can also define the boundary value problem of a partial differential equation (PDE). Since PT has been widely used and implemented in many engineering areas, particularly electric and magnetic field areas, it is crucial to estimate the first order PT solutions accurately. In this regard, the computation of PT for different geometry types is basically from the quadratic interpolation and the multivariate polynomial fitting using the least square method. The numerical calculation of the integral of the singular integral operator, ??∗which is one of the primary integral processes before we obtained the solution of PT uses the multivariate polynomial fitting. This paper aims to provide an accurate numerical solution for first order PT for different geometry types, particularly sphere and ellipsoid geometry. The numerical results of the proposed method are shown together with the comparison of its analytical solutions. From the results obtained, the numerical solution of first order PT shows higher accuracy and higher convergence as the number of surface elements increases. The numerical and the analytical solution of first order PT for a sphere is discussed and represented in graphical form. The utilization of two different software types throughout this study is Netgen Mesh Generator and MATLAB to aid the numerical computation process. The simulation and the numerical examples verify the effectiveness and efficiency of the proposed method.
Determination of trigonometric Fourier’s series by the method of four-dimensional mathematics
Authors: Rakhymova A T , Ahmedov A A , Shapen K M 
Published: August 2021

Abstract
This paper is devoted to the determination of the trigonometric Fourier series by the method of four-dimensional mathematics. In this paper, a new four-dimensional method for evaluation of the sums containing trigonometric function is proposed. Current work provides a first study and finding towards Fourier’s series in four-dimensional space.
Curvelet Based Texture Features for Breast Cancer Classifications
Authors: Yasiran Siti Salmah , Salleh Shaharuddin , Sarmin Norhaniza , Mahmud Rozi , Halim Suhaila Abd 
Published: August 2021

Abstract
One of the sources of death among women is breast cancer. It is well known that Mammogram is the best method for breast cancer detection. Subsequently, there are solid requirements for the improvement of computer aided diagnosis (CAD) systems to assist radiologists in making decision. In this paper, the curvelet changes is proposed to classify the breast cancer. Curvelet refers to multi-level change which have the characteristics of directionality and anisotropy. It splits several characteristic impediments of wavelet to edges of an image. Two component extraction techniques were created associated with curvelet and wavelet coefficients to separate among various classes of breast. Finally, the K-Nearest Neighbor (KNN) classifiers were utilized to decide if the district is unusual or ordinary. The adequacy of the suggested strategies has been implemented with Mammographic Image Analysis Society (MIAS) data images. All the dataset is utilized by the suggested strategies. Then calculations have been applied with both curvelet and wavelet for correlation test were performed. The general outcomes show that curvelet change shows superior compared to the wavelet and the thing that matters is measurably noteworthy.