bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphisms 677C > T and 1298A > C in the MTHFR gene and homocysteine levels in patients with non-alcoholic fatty liver disease as a component of the ontological model
Authors: Nosko N. A. , Rud O. M. 
Published: December 2021

Objective — to systematize literature data on the presence of 677C > T and 1298A > C polymorphisms in the MTHFR gene and homocysteine levels in patients with non‑alcoholic fatty liver disease (NAFLD); to calculate the frequencies 677C > T and 1298A > C polymorphisms combinations in the MTHFR gene and their impact on NAFLD development; to compare homocysteine levels in patients with and without NAFLD.
Materials and methods. The analysis has been performed for the results of investigation of 49 patients, from them 17 subjects with NAFLD and 32 without it. Clinical, laboratory, statistical and ontological methods were used in the study. The MTHFR 677C > T and MTHFR 1298A > C polymorphisms in the MTHFR gene were investigated with the use of real time polymerase chain reaction (RT‑PCR) technique. Homocysteine levels were determined with chemiluminescent immunoassay with reference values 3.7 — 13.9 µmol/L. Multiple logistic regression method was used to evaluate the effects 677C > T and 1298A > C polymorphisms in the MTHFR gene on NAFLD development.
Results. The variant of combination of 667С/С/1298А/А polymorphisms in the MTHFR gene (absence of mutation) was reveled in 6 (12 %) persons, that showed a widespread prevalence of variants with the presence of mutations. The correlation between variants of 677C > T and 1298A > C polymorphism in the MTHFR gene has been established (r = 0.429; p < 0.05). The results of multiple logistic regression demonstrated absence of the significant effects of 677C > T and 1298A > C polymorphisms in the MTHFR gen on NAFLD development (p > 0.05). Comparison of the homocysteine levels in patients with and without NAFLD didn’t reveal significant difference (р > 0.05), as well as comparison in the groups with combinations of 677C > T and 1298А > С polymorphisms in the MTHFR gen (р > 0.05). This can be explained by the fact that NAFLD group consisted of manly young patients without hypertension, type 2 diabetes mellitus and severe liver fibrosis.
Conclusions. Ontological systematization of the scientific data on NAFLD revealed that 677C > T and 1298A > C polymorphisms in the MTHFR gen are pathogenetically associated with the significant increase in homocysteine levels as a marker of cardiovascular pathology. Giving the multifactorial nature of hyperhomocysteinemia and wide spread of 677C > T and 1298A > C polymorphisms in the MTHFR gen in population, it seems to be impractical to use genetic investigations for MTHFR gen polymorphism in NAFLD patients routinely, but only for the purpose of differential diagnosis of hyperhomocysteinemia.
Strategi Employer Branding Perusahaan X dalam Membentuk Brand Associations (Studi Kasus pada Program Internship ‘X Star’ dan ‘X Center’ dalam Membentuk Brand Associations)
Authors: Yulianna Rica 
Published: December 2021

X Company is one of the financial companies in Indonesia that has strategy of external employer branding in the form of internship program. The internship of X Company targets students also campuses as potential employees. This strategy done to shaping and establishing corporate brand associations through several tactis that described deeper in the following research. This research is a descriptive qualitative research with a case study method. Methods for data collection was carried out through participatory observation, digital literature studies, and interviews with four resources as the implementer of internship program. The results of this study indicate that the internship of X Company has several tactics in the implementation. Those tactics such as the concept of Career Development, activity of introduction, the concept of Career Partner, and economic value factors. Finally, strategy of internship in X Company shape and establish brand associations by involving cognitive, conative, affective aspects as well as functional associations and emotional associations. Keywords: strategy, employer branding, internship, brand associations
MECHANICAL CHARACTERISTICS OF REINFORCED AND THREE-LAYER SHELLS BASED ON METAMATERIALS, TAKING INTO ACCOUNT OPERATIONAL DAMAGE
Authors: Lomakin E. V. , Yurgenson S. A. , Fedulov B. N. , Fedorenko A. N. 
Published: December 2021

Abstract—
The conventional design in aeronautical engineering is reinforced shell, which for most structures is a thin shell with a stringer set. This article compares the behavior of a conventional reinforced shell and a spaced shell metamaterial structure with a reinforced set using the example of a main airplane pressure bulkhead. The evaluation criterion is to ensure the required level of residual strength when the limiting state is reached.
Complete posterior cranial vault distraction osteogenesis to correct Chiari malformation type I associated with craniosynostosis
Authors: Park Hojin , Oh Somin , Choi Jong Woo , Ra Young Shin 
Published: December 2021

OBJECTIVE
Posterior vault distraction osteogenesis (PVDO) is an effective tool to increase intracranial volume and expand the posterior cranial fossa. During PVDO, the authors extended osteotomy posterior to the foramen magnum to fully expand the posterior cranial fossa. The aim of this study was to investigate the efficacy of complete PVDO in posterior fossa expansion and treatment of Chiari malformation type I (CM-I) in patients with craniosynostosis.

METHODS
Patients with craniosynostosis who had undergone complete PVDO between January 2012 and May 2020 were reviewed retrospectively. A coronal osteotomy extending to the foramen magnum was performed and the foramen magnum was decompressed by removing its posterior rim with a 1-mm Kerrison rongeur. Four distractor devices were placed and the vector of distraction was controlled from the posterior to the inferior-posterior direction, depending on the deformity. Changes in the intracranial volume, posterior cranial fossa area, and cerebellar tonsillar descent were measured after complete PVDO by using CT and MRI.

RESULTS
A total of 11 patients with craniosynostosis and concurrent CM-I were included in the study. The mean age was 34.6 ± 24.0 months (continuous variables are expressed as the mean ± SD throughout). One patient had sleep apnea, which was consistent with CM-I, and another patient had a headache, which was nonspecific. The intracranial volume increased from 1179.6 ± 180.2 cm3 to 1440.6 ± 251.5 cm3 (p = 0.003; 24.5% increase compared to the preoperative volume). The posterior skull base area increased from 44.9 ± 19.3 cm2 to 72.7 ± 18.1 cm2 (p = 0.004). Cerebellar tonsillar descent decreased in all 11 patients after complete PVDO (preoperative: 10.8 ± 3.7 mm, postoperative: 2.7 ± 3.0 mm; p = 0.003). Among the 11 patients, 5 showed complete resolution of cerebellar tonsillar herniation.

CONCLUSIONS
Complete PVDO can more efficiently expand the posterior cranial fossa, unlike conventional methods. Moreover, it helps to relieve cerebellar tonsillar herniation. Complete PVDO is a powerful tool to increase the intracranial and posterior fossa volumes in patients with craniosynostosis and concurrent CM-I.
Early posttraumatic seizures in pediatric traumatic brain injury: a multicenter analysis
Authors: Chong Shu-Ling , Qian Suyun , Yao Sarah Hui Wen , Allen John Carson , Dang Hongxing , Chan Lawrence C. N. , Ming Meixiu , Gan Chin Seng , Ong Jacqueline S. M. , Kurosawa Hiroshi , Lee Jan Hau 
Published: December 2021

OBJECTIVE
Early posttraumatic seizures (EPTSs) in children after traumatic brain injury (TBI) increase metabolic stress on the injured brain. The authors sought to study the demographic and radiographic predictors for EPTS, and to investigate the association between EPTS and death, and between EPTS and poor functional outcomes among children with moderate to severe TBI in Asia.

METHODS
A secondary analysis of a retrospective TBI cohort among participating centers of the Pediatric Acute & Critical Care Medicine Asian Network was performed. Children < 16 years of age with a Glasgow Coma Scale (GCS) score ≤ 13 who were admitted to pediatric intensive care units between January 2014 and October 2017 were included. Logistic regression analysis was performed to study risk factors for EPTS and to investigate the association between EPTS and death, and between EPTS and poor functional outcomes. Poor functional outcomes were defined as moderate disability, severe disability, and coma as defined by the Pediatric Cerebral Performance Category scale.

RESULTS
Overall, 313 children were analyzed, with a median age of 4.3 years (IQR 1.8–8.9 years); 162 children (51.8%) had severe TBI (GCS score < 8), and 76 children (24.3%) had EPTS. After adjusting for age, sex, and the presence of nonaccidental trauma (NAT), only younger age was significantly associated with EPTS (adjusted odds ratio [aOR] 0.85, 95% CI 0.78–0.92; p < 0.001). Forty-nine children (15.6%) in the cohort died, and 87 (32.9%) of the 264 surviving patients had poor functional outcomes. EPTS did not increase the risk of death. After adjusting for age, sex, TBI due to NAT, multiple traumas, and a GCS score < 8, the presence of EPTS was associated with poor functional outcomes (aOR 2.08, 95% CI 1.05–4.10; p = 0.036).

CONCLUSIONS
EPTSs were common among children with moderate to severe TBI in Asia and were associated with poor functional outcomes among children who survived TBI.
Leader humility and employee voice behavior: The mediating effects of work engagement and cognitive emotion regulation strategies
Authors: Tu Chiang-Kuo , Huang Shan 
Published: December 2021

BACKGROUND: Employee’s expression of voice needs cognitive and emotional resources to express the constructive challenge. Leader humility, with the characteristics of openness to new ideas and feedback, may provide employees with psychological resources to express their voice. This study considers work engagement and cognitive emotion regulation strategies as psychological resources and examines their mediating effects. OBJECTIVE: Referring to the conservation of resources theory and affective events theory, this study aims to examine the mediating effects of work engagement and cognitive emotion regulation strategies on the relationships between leader humility and employees voice behaviors. METHODS: This study conducted a questionnaire survey on managers and employees at travel enterprises in China. Based on a survey of 837 valid questionnaires, participants provided their perception for the proposed research model. RESULTS: The results show that enhancing work engagement and controlled emotion regulation strategies and reducing automatic emotion regulation strategies partially mediate the relationships between leader humility and employee’s prohibitive voice. CONCLUSIONS: Enhancing work engagement and reducing automatic emotion regulation strategies have the mediating effects. However, controlled emotion regulation strategies and promotive voice need much psychological resources, employee adopting controlled emotion regulation doesn’t affect promotive voice and have mediating effects significantly.
The Implementation of Online Accent Reduction Software to Improve Pronunciation of English and Arabic Department Students
Authors: Asmawati Nur , Fitriningsih Fitriningsih 
Published: December 2021

The objective of this study is to implement accent reduction software in English pronunciation teaching. This study employed an experimental approach. There were forty students recruited from the English and Arabic departments. The students were split into two classes, with one class being treated as an experimental class and another class as a controlled class. Each class consisted of twenty students, ten English department students, and the other ten Arabic department students. We administered an experimental class with twelve meeting treatments using the Elsa accent reduction software to teach English pronunciation. Meanwhile, the controlled class was not given any treatments. The results show that there was a significant difference between the result of the pre-test and post-test of the students' pronunciations that were taught with the accent reduction software. It was found that the mean score of the experimental class was significantly improved from 53.12 to 85.44 after they were given the treatment. Meanwhile, the control group's mean score was also improved, but it was not significant from 49.33 to 59.11. Our study highlighted that the use of accent reduction software in teaching English pronunciations could help students to improve their English pronunciations. The students were able to imitate an English sound from the software. The limitation of this study is that we did not compare the results of English and Arabic students’ ability in pronunciations after the use of the software. Future studies are recommended to compare pronunciations between English and Arabic students through the use of the software to understand language background might affect the treatment.
Типологія систем кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) призначення
Authors: Живило Євген , Шевченко Дмитро , Черноног Олександр 
Published: December 2021

В статті розглянуте актуальне питання щодо підходів визначення типології систем кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) призначення. Проаналізовані останні дослідження і публікації з цього питання. Проведений аналіз та досвід провідних країн світу, свідчить про те, що в умовах сучасних бойових дій ефективне функціонування системи кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) призначення буде в умовах постійного впливу противника. За цих умов трансформація поглядів на питання створення систем кібербезпеки і кібероборони та, відповідно, розвиток їх структур та типологій в провідних країнах світу відбувається під впливом розвитку технологій, змін у безпековому середовищі, формах, способах та технологіях ведення війн і нових досягнень в цьому. В статті запропоновано підхід типологізації систем кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) призначення.
В статті визначені об’єкти кібервпливу: технічні системи, соціум протиборчої сторони, соціотехнічні системи і когнітивний простір. Розглянуті сфери і галузі що підлягають кіберзахисту та кіберобороні та надана їх коротка характеристика. Запропонована типологія систем кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) призначення за її функціональним призначенням і складовим. Проаналізована система кібербезпеки в ІТС військового (спеціального) призначення провідних країн світу та країн-членів НАТО розкриті її функціональні підсистеми.
В статті розглянуто методичний підхід для вирішення прикладної задачі, яка полягає у визначенні підходів для створення типології зазначених систем.
Запропонована типологія систем кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) призначення враховує об’єкти кібервпливу, які обумовлені особливостями кібердій у кіберпросторі в сучасних умовах. Це дає можливість втілити типологію системи кібербезпеки в інформаційно-телекомунікаційних системах військового (спеціального) в цілому, окремих елементів та її складових. Запропоновано найбільш раціональний варіант створення типології систем кібербезпеки, якій відповідно до сучасних тенденцій розвитку, з урахуванням військово-політичної обстановки, національних інтересів та законодавства, забезпечить інформаційну, кібернетичну та когнітивну перевагу над противником та буде сприяти практичній реалізації прийнятої в країнах членах НАТО концепції “смарт-оборони”.
Geologi Pegunungan Mendoke, Lengan Tenggara Pulau Sulawesi, Indonesia
Authors: Hasria Hasria , Idrus Arifudin , Warmada I Wayan 
Published: December 2021

Penelitian ini dilakukan di Pegunungan Mendoke pada Lengan Tenggara Pulau Sulawesi Indonesia. Tujuan penelitian adalah untuk mengetahui geomorfologi, stratigrafi dan struktur geologi di Pegunungan Mendoke. Metode penelitian yang digunakan adalah studi pustaka, pekerjaan lapangan, analisis laboratorium berupa analisis petrografi, serta interpretasi data labororium danÂ hasil pengamatan lapangan. Hasil penelitian menunjukkan bahwa geomorfologi di daerah penelitian terdiri atas 3 (tiga) satuan, yaitu satuan dataran rendah, satuan perbukitan rendah berlereng sangat landai hingga agak curam danÂ satuan pegunungan berlereng agak curam hingga sangat curam. Adapun stratigrafi daerah penelitian dibagi menjadi 7 (tujuh) satuan, yaitu Satuan Sekis Mengkoka, Satuan Sekis Pompangeo, Satuan Intrusi Diorit, Satuan Serpentinit Harzburgit Ultramafik, Satuan Batupasir Konglomerat Langkowala, Satuan Batupasir Boepinang dan Satuan Endapan Aluvial. Daerah penelitian dikontrol oleh struktur geologi berarah tenggara-baratlaut danÂ timur-barat. Katakunci: Pegunungan Mendoke, geomorfologi, stratigrafi, struktur geologi.
Delineasi Batuan Granit dan Sedimen Daerah Bintan dan Sekitarnya, Kepulauan Riau Berdasarkan Analisis Data Gayaberat
Authors: Setiadi Imam , D. Aryanto Noorcahyo , Nurdin Nazar 
Published: December 2021

Kepulauan Riau merupakan bagian dari jalur granit utama pembawa mineral dan timah, cebakan atau pengkayaan mineral diperkirakan terakumulasi sebagai endapan plaser Kuarter yang menempati lembah purba. Studi mengenai penyebaran batuan granit dan sedimen berdasarkan analisis data gayaberat di daerah ini belum pernah dilakukan. Pada eksplorasi sumberdaya mineral khususnya timah dan unsur tanah jarang, informasi mengenai keberadaan batuan granit penting dilakukan untuk mengetahui batuan sumber mineral tersebut. Penelitian dilakukan dengan tujuan untuk mengetahui pola penyebaran batuan granit dan batuan sedimen yang terdapat pada daerah Pulau Bintan dan sekitarnya. Metode yang dilakukan yaitu dengan cara melakukan analisis data gayaberat menggunakan analisis spektral dan bandpass filter, serta pemodelan 3D inversi. Hasil analisis spektral menunjukkan ketebalan batuan sedimen rata-rata diperkirakan sebesar 1,25 km, sedangkan hasil aplikasi bandpass filter menggunakan panjang gelombang cutoff dengan batas bawah 10.000 m dan batas atas 30.000 m digunakan untuk menentukan anomali regional dan residual. Hasil analisis kualitatif memperlihatkan bahwa batuan sedimen menempati bagian baratlaut, tenggara dan baratdaya daerah penelitian, sedangkan pola penyebaran batuan granit mempunyai arah relatif baratlaut-tenggara dan utara-selatan sesuai dengan penyebaran kecenderungan regional jalur granit. Hasil pemodelan inversi 3D gayaberat menunjukkan bahwa batuan granit mempunyai nilai rapat massa rata-rata sebesar 2,65 gr/cc dan batuan sedimen mempunyai nilai rapat massa sekitar 2,4 gr/cc. Batuan granit yang muncul berdasarkan model merupakan batolit dan pada bagian atas mengalami pelapukan, batuan granit yang tererosi selanjutnya terdendapkan yang mengisi lembah-lembah sebagai batuan sedimen yang kemungkinan membawa mineral-mineral ekonomis di daerah penelitianKatakunci:Â Batuan granit dan sedimen, gayaberat, bandpass filter, pemodelan 3D, Pulau Bintan, Riau.
Fasies Sedimentasi dan Elemen Arsitektur Formasi Citalang di Desa Sidamukti, Majalengka, Provinsi Jawa Barat
Authors: Fathan Al-Hakim Abdul Fauzan , Rizal Yan 
Published: December 2021

Daerah Majalengka merupakan satu daerah di Jawa Barat yang sangat menarik untuk dilakukan kajian geologi baik yang berkaitan dengan sedimentologi, tektonik maupun paleontologi. Salah satu objek yang menarik untuk dikaji ulang adalah Formasi Citalang, dimana uraian tentang formasi ini masih banyak terdapat perbedaan tentang satuan batuan penyusunnya, umur dan lingkungan pengendapannya. Disini kajian tentang formasi Citalang ditinjau dari sedimentologinya.Formasi Citalang di daerah penelitian Desa Sidamukti, Kabupaten Majalengka, Provinsi Jawa Barat tersusun atas 6 satuan batuan, yaitu: perselingan batupasir dan konglomerat sisipan tuf, perselingan batupasir dan batulempung, perselingan batupasir dan konglomerat, batupasir sisipan batulanau, perselingan batupasir dan konglomerat dengan sisipan batulanau, serta perselingan batupasir dan batulanau. Dari pengukuran penampang stratigrafi lintasan terpilih didapatkan 10 litofasies yang secara keseluruhan dijumpai dalam masing-masing satuan batuan, berupa: Fine MudÂ (Fm), Fine Silt Mud (Fsm), Massive Sandstone (Sm), Horizontal Sandstone (Sh), Low Angle Cross Lamination Sandstone (Sl), Ripple Cross Lamination Sandstone (Sr), Trough Cross Bed Sandstone (St), Gravel Matrix Supported Graded Bedding (Gmg), Gravel Clast Supported Graded Bedding (Gcg), Gravel Clast Supported Massive (Gcm). Elemen arsitektural yang terbentuk pada sistem pengendapan Formasi Citalang adalahÂ Gravel Bar and Bedforms (GB), Sandy Bedform (SB), dan Sediment Gravity Flow (SG), yang diinterpretasikan terjadi pada lingkungan pengendapan fluvial berupa sungai teranyam.Katakunci: Formasi Citalang, elemen arsitektur, fluvial, litofasies, sungai teranyam.
Penilaian Potensi Bencana Gempabumi dan Tsunami untuk Pelindungan Infrastruktur Migas dan PLTU di Cilacap, Jawa Tengah
Authors: Soehaimi A. , Sinung Baskoro S.R , Soebowo Eko , Ma'mur Ma'mur , Sopyan Yayan 
Published: December 2021

Kilang minyak Pertamina dan PLTU Indonesia Power milik pemerintah di Kota Cilacap berada di wilayah dengan percepatan tanah puncak (PGA) = 0,4-0,5 g, percepatan pseudo spectralÂ (PSA Ss)Â = 0,9-1 g dan (PSA S1) = 0,4-0,5g pada situs batuan SB, 2% probabilitas dalam 50 tahun (SNI 1726:2019). Penilaian potensi bencana gempabumi di kota ini pada kelas situs SC memiliki nilai SDS= 0,67g dan SD1= 0,43 g, sedangkan SDS = 0,73g dan SD1= 0,50 g pada kelas situs SD. Sesuai dengan ketentuan SNI 1726:2019, struktur gedung dan non gedung katagori risiko I, II, III dan IV padaÂ kelas situs SC dan SD tersebut di atas berkatagori desain seismik D. Gaya geser desain seismik pada dasar silos tangki minyak adalah Qd = (0,24~ 0,34)*10496,4 x 103 =(2.309,21~2.519,14) x 103 (N). Potensi landaan tsunami dengan runup high berkisar antara 2,5-6 m. Bangunan gedung dan non gedung yang tidak sesuai dengan katagori desain seismik, dapat dilakukan penguatan atau retrofitting sesuai ketentuan. Untuk memperkecil gaya geser desain seismik pada dasar silos, dapat dilakukan dengan rekayasa keteknikan pada fondasi. Untuk meminimalisir bahaya tsunami dapat dibuat tembok penahan atau ditanam pemecah gelombang tsunami (sea wave tsunami breaker) di sekitar kilang minyak dan PLTU yang berhadapan langsung dengan laut. Jalur evakuasi tsunami berupa jalan lebar dengan arah selatan-utara dan bangunan bertingkat penyelamatan tsunami di sepanjang jalan di kota ini sebaiknya dibuat, khususnya di wilayah sekitar kilang minyak dan PLTU.Katakunci: Katagori risiko, katagori desain seismik, runup high, tsunami.