bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoparticle mediated RNA delivery for wound healing
Authors: Kolanthai Elayaraja , Fu Yifei , Kumar Udit , Babu Balaashwin , Venkatesan Architha Krishnammal , Liechty Kenneth W. , Seal Sudipta 
Published: August 2021

AbstractWound healing is a complicated physiological process that comprises various steps, including hemostasis, inflammation, proliferation, and remodeling. The wound healing process is significantly affected by coexisting disease states such as diabetes, immunosuppression, or vascular disease. It can also be impacted by age, repeated injury, or hypertrophic scarring. These comorbidities can affect the rate of wound closure, the quality of wound closure, and tissues' function at the affected sites. There are limited options to improve the rate or quality of wound healing, creating a significant unmet need. Advances in nucleic acid research and the human genome project have developed potential novel approaches to address these outstanding requirements. In particular, the use of microRNA, short hairpin RNA, and silencing RNA is unique in their abilities as key regulators within the physiologic machinery of the cell. Although this innovative therapeutic approach using ribonucleic acid (RNA) is an attractive approach, the application as a therapeutic remains a challenge due to site‐specific delivery, off‐target effects, and RNA degradation obstacles. An ideal delivery system is essential for successful gene delivery. An ideal delivery system should result in high bioactivity, inhibit rapid dilution, controlled release, allow specific activation timings facilitating physiological stability, and minimize multiple dosages. Currently, these goals can be achieved by inorganic nanoparticle (NP) (e.g., cerium oxide, gold, silica, etc.) based delivery systems. This review focuses on providing insight into the preeminent research carried out on various RNAs and their delivery through NPs for effective wound healing.This article is categorized under:
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures
Fragmentation and defragmentation of strings in type IIA and their holographic duals
Authors: Roychowdhury Dibakar 
Published: August 2021

Abstract
We probe type IIA geometries with folded semiclassical strings those encode the strong coupling dynamics associated with long operators in a class of SCFTs pertaining to spacetimes whose dimension vary from 6d down to 2d. We particularly focus on folded string configurations those are extended through stack of flavor Dp (p = 6, 8) branes localized along the internal manifold. Considering some specific examples within the realm of $$ \mathcal{N} $$
N
= 2 linear quivers, we show that the associated string spectrum exhibits a pole as the string approaches flavor D6 branes. We identify this as a fragmentation of long operators in the dual $$ \mathcal{N} $$
N
= 2 SCFTs. On the other hand, a similar analysis for $$ \mathcal{N} $$
N
= (1, 0) SCFTs in 6d as well as $$ \mathcal{N} $$
N
= (0, 4) SCFTs in 4d reveals a set of new dispersion relations at strong coupling. Based on semiclassical calculations, we set an argument that explains either of these cases.
Dissociated face- and word-selective intracerebral responses in the human ventral occipito-temporal cortex
Authors: Hagen Simen , Lochy Aliette , Jacques Corentin , Maillard Louis , Colnat-Coulbois Sophie , Jonas Jacques , Rossion Bruno 
Published: August 2021

AbstractThe extent to which faces and written words share neural circuitry in the human brain is actively debated. Here, we compare face-selective and word-selective responses in a large group of patients (N = 37) implanted with intracerebral electrodes in the ventral occipito-temporal cortex (VOTC). Both face-selective (i.e., significantly different responses to faces vs. non-face visual objects) and word-selective (i.e., significantly different responses to words vs. pseudofonts) neural activity is isolated with frequency-tagging. Critically, this sensitive approach allows to objectively quantify category-selective neural responses and disentangle them from general visual responses. About 70% of significant electrode contacts show either face-selectivity or word-selectivity only, with the expected right and left hemispheric dominance, respectively. Spatial dissociations are also found within core regions of face and word processing, with a medio-lateral dissociation in the fusiform gyrus (FG) and surrounding sulci, respectively. In the 30% of overlapping face- and word-selective contacts across the VOTC or in the FG and surrounding sulci, between-category-selective amplitudes (faces vs. words) show no-to-weak correlations, despite strong correlations in both the within-category-selective amplitudes (face–face, word–word) and the general visual responses to words and faces. Overall, these observations support the view that category-selective circuitry for faces and written words is largely dissociated in the human adult VOTC.
The VC Dimension of Metric Balls under Fréchet and Hausdorff Distances
Authors: Driemel Anne , Nusser André , Phillips Jeff M. , Psarros Ioannis 
Published: August 2021

AbstractThe Vapnik–Chervonenkis dimension provides a notion of complexity for systems of sets. If the VC dimension is small, then knowing this can drastically simplify fundamental computational tasks such as classification, range counting, and density estimation through the use of sampling bounds. We analyze set systems where the ground set X is a set of polygonal curves in $$\mathbb {R}^d$$

R

d

and the sets $$\mathcal {R}$$
R
are metric balls defined by curve similarity metrics, such as the Fréchet distance and the Hausdorff distance, as well as their discrete counterparts. We derive upper and lower bounds on the VC dimension that imply useful sampling bounds in the setting that the number of curves is large, but the complexity of the individual curves is small. Our upper and lower bounds are either near-quadratic or near-linear in the complexity of the curves that define the ranges and they are logarithmic in the complexity of the curves that define the ground set.
Advanced backward planning with custom-milled individual allogeneic block augmentation for maxillary full-arch osteoplasty and dental implantation:a 3-year follow-up
Authors: Nilius Manfred , Mueller Charlotte , Nilius Minou Helene , Haim Dominik , Weiland Bernhard , Lauer Guenter 
Published: August 2021

AbstractIn the case of maxillary involution, augmentation is necessary for implant-supported prosthetics. The use of bone grafts is standard; customized allogeneic bone blocks may be a predictable alternative before dental implantation. For maxillary full-arch reconstruction, this case shows a horse-shoe augmentation by four allogeneic blocks, followed by guided dental implantation and fixed prosthetics after 6 months of healing. Using allogeneic blocks is an option for full-arch maxillary augmentation and comparable with autologous bone grafts. There is no donor site comorbidity. Bone height is stable for a minimum of 3 years after loading with resorption less than 10% in vertical, buccolingual, and mesiodistal directions. Short-implants allow for the long-term stability of prosthetic fixtures. Prefabricated customized allogeneic blocks for augmentation may increase the fitting accuracy of the graft, decrease morbidity, and lower operation time in maxillary full-arch reconstruction. The percentage of resorption after 3 years is comparable to the commonly used iliac crest.
“They say this is a home”: the challenge of “home” in residential care settings for old and young
Authors: Börjesson Ulrika , Torgé Cristina Joy 
Published: August 2021

AbstractIn this article, we want to bolster a critical discussion of how the “home” is used in research on residential care, and additionally make sense of young and old residents’ feelings of resistance, through the lens of a critical geography of home. We illustrate how the home ideal might be provocative and frustrating for the residents, although previous studies point out that the ideal is used by staff and in policy to reassure residents of a sense of belonging and mastery. Examples from interviews with young unaccompanied boys as well as older residents living in residential care have been used and the analysis resulted in two themes: “Residents’ conflicting experiences of space” (shared space, restricted space and regulated space, and “Residents’ feelings of homelessness” (transitional space and encroached space). How the residents themselves understand the space that is called their home and why their home can stir ambivalent or negative feelings of isolation, exclusion, and homelessness, is relevant in order to avoid romanticizing home. Residents’ understanding of home can be different from the staff, a reminder that home is a much more complex notion than the rosy ideal.
Pots as alternative and sustainable fishing gears in the Mediterranean Sea: an overview
Authors: Petetta Andrea , Virgili Massimo , Guicciardi Stefano , Lucchetti Alessandro 
Published: August 2021

AbstractStock overexploitation, bycatch, discards and gear impacts on the environment are outstanding issues for Mediterranean fisheries. The adoption of alternative fishing gears is an appealing solution to ensure a more sustainable exploitation of resources. We discuss the pros and cons of pots as alternative gears by reviewing their main designs, spatial distribution and target species in the Mediterranean basin. We assessed the technical factors affecting the catch efficiency of the different pot designs for four target species: spiny lobster, Palinurus elephas; Norway lobster, Nephrops norvegicus; common octopus, Octopus vulgaris and pandalid shrimps, Plesionika spp. We found that pot volume is important to catch Octopus; mesh size to catch Nephrops and Plesionika; entrance surface to catch Octopus, Nephrops and Plesionika; pot shape/colour and entrance shape/position to catch Octopus and Plesionika; and bait type to catch Octopus and Nephrops. The literature review shows that pot fisheries have several considerable advantages over conventional gears, especially in terms of discards, bycatch, seabed impacts (particularly compared with bottom trawls and passive set nets), size and species selectivity, gear depredation, catch quality and gear cost, besides saving time and labour. Disadvantages hampering their wider diffusion include ghost fishing, a low catch of finfish species, the narrow range of species targeted by each pot design and the current early stage of research. These data make a clear case for using pots as alternative gears to traditional ones in the Mediterranean Sea in some areas and seasons to catch certain target species.
Translational Development of a Zr-89-Labeled Inhibitor of Prostate-specific Membrane Antigen for PET Imaging in Prostate Cancer
Authors: Vázquez Sergio Muñoz , Endepols Heike , Fischer Thomas , Tawadros Samir-Ghali , Hohberg Melanie , Zimmermanns Beate , Dietlein Felix , Neumaier Bernd , Drzezga Alexander , Dietlein Markus , Schomäcker Klaus 
Published: August 2021

AbstractPurposeWe present here a Zr-89-labeled inhibitor of prostate-specific membrane antigen (PSMA) as a complement to the already established F-18- or Ga-68-ligands.ProceduresThe precursor PSMA-DFO (ABX) was used for Zr-89-labeling. This is not an antibody, but a peptide analogue of the precursor for the production of [177Lu]Lu-PSMA-617. The ligand [89Zr]Zr-PSMA-DFO was compared with [68Ga]Ga-PSMA-11 and [18F]F-JK-PSMA-7in vitroby determination of theKdvalue, cellular uptake, internalization in LNCaP cells, biodistribution studies with LNCaP prostate tumor xenografts in mice, andin vivoby small-animal PET imaging in LNCaP tumor mouse models. A first-in-human PET was performed with [89Zr]Zr-PSMA-DFO on a patient presenting with a biochemical recurrence after brachytherapy and an ambiguous intraprostatic finding with [18F]F-JK-PSMA-7 but histologically benign cells in a prostate biopsy 7 months previously.Results[89Zr]Zr-PSMA-DFO was prepared with a radiochemical purity ≥ 99.9% and a very highin vitrostability for up to 7 days at 37 °C. All radiotracers showed similar specific cellular binding and internalization,in vitroand comparable tumor uptake in biodistribution experiments during the first 5 h. The [89Zr]Zr-PSMA-DFO achieved significantly higher tumor/background ratios in LNCaP tumor xenografts (tumor/blood: 309 ± 89, tumor/muscle: 450 ± 38) after 24 h than [68Ga]Ga-PSMA-11 (tumor/blood: 112 ± 57, tumor/muscle: 58 ± 36) or [18F]F-JK-PSMA-7 (tumor/blood: 175 ± 30, tumor/muscle: 114 ± 14) after 4 h (p < 0.01). Small-animal PET imaging demonstratedin vivothat tumor visualization with [89Zr]Zr-PSMA-DFO is comparable to [68Ga]Ga-PSMA-11 or [18F]F-JK-PSMA-7 at early time points (1 h p.i.) and that PET scans up to 48 h p.i. clearly visualized the tumor at late time points. A late [89Zr]Zr-PSMA-DFO PET scan on a patient with biochemical recurrence (BCR) had demonstrated intensive tracer accumulation in the right (SUVmax13.25, 48 h p.i.) and in the left prostate lobe (SUV max 9.47), a repeat biopsy revealed cancer cells on both sides.Conclusion[89Zr]Zr-PSMA-DFO is a promising PSMA PET tracer for detection of tumor areas with lower PSMA expression and thus warrants further clinical evaluation.
Theoretical solution for drained cylindrical cavity expansion in clays with fabric anisotropy and structure
Authors: Castro Jorge , Sivasithamparam Nallathamby 
Published: August 2021

AbstractThis paper presents a novel, exact, semi-analytical solution for the quasi-static drained expansion of a cylindrical cavity in soft soils with fabric anisotropy and structure. The assumed constitutive model is the S-CLAY1S model, which is a Cam clay-type model that considers fabric anisotropy that evolves with plastic strains, structure and gradual degradation of bonding (destructuration) due to plastic straining. The solution involves the numerical integration of a system of eight first-order ordinary differential equations, three of them corresponding to the effective stresses in cylindrical coordinates, other three corresponding to the components of the fabric tensor and one corresponding to the amount of bonding and another corresponding to the specific volume. The solution is validated against finite element analyses. When destructuration is considered, the solution provides slightly lower values of the effective radial and mean stresses near the cavity wall. Besides, the specific volume is further reduced due to loss of bonding. Parametric analyses and discussion of the influence of soil overconsolidation, expansion of the cavity and initial amount of bonding are presented.
Coffee and Arterial Hypertension
Authors: Surma Stanisław , Oparil Suzanne 
Published: August 2021

Abstract
Purpose of Review
Coffee is a very popular drink and an estimated 2.25 billion cups worldwide are consumed daily. Such popularity of coffee makes it the most consumed drink next to water. Numerous studies have shown a beneficial effect of habitual and moderate coffee consumption on the functioning of the nervous, digestive, and cardiovascular systems, as well as on kidney function. Taking into account the very high prevalence of arterial hypertension in the world (31.1% of adults), much controversy has been raised about the influence of coffee consumption on blood pressure and the risk of arterial hypertension. Moreover, there have been extensive discussions about the safety of coffee consumption for hypertensive persons.

Recent Findings
There are over 1000 chemical compounds in coffee. The best characterized of these are caffeine, chlorogenic acid, trigonelline, kahweol, cafestol, ferulic acid, and melanoidins. These compounds have bidirectional influences on blood pressure regulation. The results of numerous studies and meta-analyses indicate that moderate and habitual coffee consumption does not increase and may even reduce the risk of developing arterial hypertension. Conversely, occasional coffee consumption has hypertensinogenic effects. Moderate habitual coffee consumption in hypertensive persons does not appear to increase the risk of uncontrolled blood pressure and may even reduce the risk of death from any cause.

Summary
Moderate and habitual consumption of coffee (1-–3 cups / day) does not adversely affect blood pressure in most people, including those with arterial hypertension.
Cryptocurrencies activity as a complex network: Analysis of transactions graphs
Authors: Serena Luca , Ferretti Stefano , D’Angelo Gabriele 
Published: August 2021

AbstractThe number of users approaching the world of cryptocurrencies exploded in the last years, and consequently the daily interactions on their underlying distributed ledgers have intensified. In this paper, we analyze the flow of these digital transactions in a certain period of time, trying to discover important insights on the typical use of these technologies by studying, through complex network theory, the patterns of interactions in four prominent and different Distributed Ledger Technologies (DLTs), namely Bitcoin, DogeCoin, Ethereum, Ripple. In particular, we describe the Distributed Ledger Network Analyzer (DiLeNA), a software tool for the investigation of the transactions network recorded in DLTs. We show that studying the network characteristics and peculiarities is of paramount importance, in order to understand how users interact in the DLT. For instance, our analyses reveal that all transaction graphs exhibit small world properties.
When your favorites disappoint: Self-construal influences response to disappointing brand experiences
Authors: Zafrani Oded , White Tiffany B. , Riemer Hila 
Published: August 2021

AbstractThis research examined the effect of self-construal (independent vs. interdependent) on people’s responses to disappointing brand experiences. We propose that following a disappointing brand experience, independents are more likely than interdependents to express intentions for negative behavior. This effect is due to differences in the importance ascribed to various goals: independents are focused on their own personal goals and expectations, whereas interdependents are focused on maintaining pleasant and harmonious relationships. Consequently, when independents experience disappointment (i.e., their expectations are not met), they appraise the situation as less pleasant than do interdependents. Independents are thus more likely to experience negative emotions, which in turn lead to negative behavioral intentions. Three studies, in which self-construal was primed, supported this prediction. In experiment 1 participants imagined a sports event where their favorite team played carelessly and lost. Participants in the independent (vs. interdependent) prime condition were more likely to express intentions of negative behavior toward the sports team; negative emotions partially mediated this effect. Experiment 2 provides evidence for the mediating role of emotional appraisal in the extent to which the disappointing experience (sports event) is perceived as unpleasant. Experiment 3 replicates these findings in the context of service failure at a restaurant. It also provides evidence for the role of prior expectations in this effect, demonstrating that the effect occurs only when participants have prior expectations, and does not occur in their absence. This research sheds light on the effects of self-construal on emotional and behavioral responses to negative brand experiences, and highlights the processes underlying these effects.
Stressincontinentie bij mannen: prospectieve dataregistratie en studies dringend nodig
Authors: Martens Frank M. J. , Cornel Erik B. 
Published: August 2021

SamenvattingIn dit opiniestuk proberen de auteurs de volgende vraag te beantwoorden: ‘stressincontinentie bij mannen: waarom we prospectieve studies nodig hebben’. We leggen uit dat een jarenlang bestaande gouden standaard als operatieve oplossing, namelijk de sfincterprothese, en overhaaste introductie van allerlei andere chirurgische oplossingen zoals de verschillende male slings en de verschillende indicaties voor deze ingrepen, randomized controlled trials bemoeilijken. We benadrukken dat naar onze mening anamnese en resultaten op een gestandaardiseerde manier moeten plaatsvinden. Alleen op die manier zal het in de toekomst mogelijk worden onderzoeksresultaten te vergelijken en een uitspraak te doen over wanneer welke incontinentieoperatie geïndiceerd is en wellicht ook nog door wie in welk centrum. Het is niet de bedoeling een klinkklare oplossing voor de toekomst te geven, maar wel om de discussie te verlevendigen.
Imposter Syndrome in Surgical Trainees: Clance Imposter Phenomenon Scale Assessment in General Surgery Residents
Authors: Bhama Anuradha R. , Ritz Ethan M. , Anand Rahul J. , Auyang Edward D. , Lipman Jeremy , Greenberg Jacob A. , Kapadia Muneera R. 
Published: August 2021

BACKGROUND:
Imposter syndrome occurs when high-achieving individuals have a pervasive sense of self-doubt combined with fear of being exposed as a fraud, despite objective measures of success. This threatens mental health and well-being. The prevalence and severity of imposter syndrome has not been studied among general surgery residents on a large scale. The primary outcomes of this study were the prevalence and severity of imposter syndrome.

STUDY DESIGN:
The Clance Impostor Phenomenon Scale was administered to residents at 6 academic general surgery residency programs. Multivariable analysis was performed to identify significant differences among groups and predictive characteristics of imposter syndrome.

RESULTS:
One hundred and forty-four residents completed the assessment (response rate 46.6%; 47.2% were male). Only 22.9% had “none to mild” or “moderate” imposter syndrome. A majority (76%) had “significant” or “severe” imposter syndrome. There were no significant differences in mean scores among male and female residents (p = 0.69). White residents had a mean score of 71.3 and non-White residents had a mean score of 68.3 (p = 0.24). There was no significant difference between PGY1 to PGY5 or research residents (p = 0.72). There were no significant differences based on US Medical Licensing Examination or American Board of Surgery In-Service Training Examination scores (p = 0.18 and p = 0.37, respectively).

CONCLUSIONS:
Imposter syndrome is prevalent among general surgery residents, with 76% of residents reporting either significant or severe imposter syndrome. There were no predictive characteristics based on demographics or academic achievement, suggesting that there is something either inherent to those choosing general surgery training or the general surgery training culture that leads to such substantive levels of imposter syndrome.
Relationships between vaccinations, herd introductions, and livestock losses in Northern Tanzania
Authors: Ahmed Haseeb , Yoder Jonathan , de Glanville William , Davis Alicia , Kibona Tito J. , Cleaveland Sarah 
Published: August 2021

AbstractThis article examines the relationships between livestock vaccinations, herd introduction decisions, and livestock disease–related outcomes. We develop a theoretical model and derive testable hypotheses about the relationships between these outcomes and practices and test them using two-stage least squares regression analysis. We find that vaccinations reduce disease-related livestock deaths, implying that vaccine availability and use may improve herd and household welfare. We do not find robust evidence of increase in disease-related illness due to herd introductions. Our results highlight the role of livestock vaccinations in safeguarding herd value, which is connected to broader household welfare for livestock keepers of Eastern Africa.