bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of non-COVID-19 critically ill patients during the COVID-19 pandemic
Authors: Bologheanu Răzvan , Maleczek Mathias , Laxar Daniel , Kimberger Oliver 
Published: April 2021

Summary
Background
Coronavirus disease 2019 (COVID-19) disrupts routine care and alters treatment pathways in every medical specialty, including intensive care medicine, which has been at the core of the pandemic response. The impact of the pandemic is inevitably not limited to patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their outcomes; however, the impact of COVID-19 on intensive care has not yet been analyzed.

Methods
The objective of this propensity score-matched study was to compare the clinical outcomes of non-COVID-19 critically ill patients with the outcomes of prepandemic patients. Critically ill, non-COVID-19 patients admitted to the intensive care unit (ICU) during the first wave of the pandemic were matched with patients admitted in the previous year. Mortality, length of stay, and rate of readmission were compared between the two groups after matching.

Results
A total of 211 critically ill SARS-CoV‑2 negative patients admitted between 13 March 2020 and 16 May 2020 were matched to 211 controls, selected from a matching pool of 1421 eligible patients admitted to the ICU in 2019. After matching, the outcomes were not significantly different between the two groups: ICU mortality was 5.2% in 2019 and 8.5% in 2020, p = 0.248, while intrahospital mortality was 10.9% in 2019 and 14.2% in 2020, p = 0.378. The median ICU length of stay was similar in 2019: 4 days (IQR 2–6) compared to 2020: 4 days (IQR 2–7), p = 0.196. The rate of ICU readmission was 15.6% in 2019 and 10.9% in 2020, p = 0.344.

Conclusion
In this retrospective single center study, mortality, ICU length of stay, and rate of ICU readmission did not differ significantly between patients admitted to the ICU during the implementation of hospital-wide COVID-19 contingency planning and patients admitted to the ICU before the pandemic.
Toward a fully resolved volume of fluid simulation of the phase inversion problem
Authors: Saeedipour Mahdi , Vincent Stéphane , Estivalezes Jean-Luc 
Published: April 2021

AbstractThis paper presents an enstrophy-resolved simulation of the phase inversion problem using the volume of fluid (VOF) method. This well-known benchmark for modeling multiphase flows features a buoyancy-driven unsteady motion of a light fluid into a heavy one followed by several large- and small-scale interfacial processes such as deformation, ligament formation, interface breakup, and coalescence. A fully resolved description of such flow is advantageous for a priori and a posteriori evaluations when developing new subgrid-scale closure models for large eddy simulation of two-phase flows. However, most of the previous attempts in performing the direct numerical simulation of this problem have been unsuccessful to reach grid-independent high-order flow statistics such as enstrophy. The key contribution of this paper lies in proposing a new converging configuration for this problem by reducing the Reynolds and Weber numbers. The new setup reaches grid convergence for all the flow characteristics on a $$512^3$$

512
3

grid. Particularly, the enstrophy which has always revealed a grid-dependent behavior in all the previous studies converges for the proposed setup. Also, we analyze the temporal evolution of interfacial structures including the statistics of the total interfacial area during the process on different grid resolutions. First, no convergence on the interfacial area is observed and the possible reasons for lack of convergence are discussed. The potential remedies are investigated through a comprehensive parameter study. The findings highlight that (i) the enstrophy always converges for these moderate Re and We numbers, and (ii) the convergence of the total interfacial area is sensitive to the choice of initial and wall boundary conditions. Then, a new setup based on this sensitivity analysis is proposed that succeeded in full convergence for enstrophy and a partial convergence for the total interfacial area. The numerical simulations were carried out using the VOF solvers of OpenFOAM with a comparison between the algebraic and geometric schemes. Besides, the convergence of size distribution of dispersed structures is investigated. The present study provides insight into the possible directions toward a DNS of phase inversion problem with all the flow and interfacial structures resolved, which is essential for the future development of multiphase flow models.
Dental injuries in paediatric mandibular fracture patients
Authors: Kannari Leena , Marttila Emilia , Thorén Hanna , Snäll Johanna 
Published: April 2021

Abstract
Purpose
Dental injuries (DIs) are associated with facial fractures, particularly mandibular fractures. As paediatric mandibular fractures have special features, we sought to clarify the occurrence and types of DIs among this patient group. We assessed how age, injury type, and fracture location affects the occurrence of DIs and thereby defined which patients are most susceptible.

Methods
This retrospective study included patients < 18 years with a recent mandibular fracture. Predictor variables were gender, age group, mechanism of injury, type of mandibular fracture, and other associated facial fracture(s). Types and locations of DIs and tooth loss due to injury were also reported.

Results
DIs were detected in 34.7% (n = 41) out of 118 patients. Patients with tooth injury had on average 3.5 injured teeth. A total of 16.2% of injured teeth were lost, typically at the time of the injury. Loss of at least one tooth was seen in approximately 10% of patients. Avulsion was the most common cause of tooth loss (52.2%). Non-complicated crown fracture (50.7%) was the most common DI type. Statistically significant associations between studied variables and DIs were not detected.

Conclusion
DIs are common and often multiple in paediatric mandibular fracture patients regardless of background factors. DIs often lead to tooth loss. Prompt replantation of an avulsed tooth, early detection of DIs, and prevention of tooth loss whenever possible are important to avoid permanent tooth defects.
Eigenspannungsorientiertes Fügen von hybriden Bauteilen mittels Radial-Walzen
Authors: Guilleaume Christina , Kühne David , Kästner Markus , Brosius Alexander 
Published: April 2021

ZusammenfassungFlexible Fertigungsprozesse in der Umformtechnik ermöglichen es, schnell und effizient auf veränderliche Rahmenbedingungen beispielsweise durch Kundenwünsche und rechtliche Anforderungen reagieren zu können. Besonders die inkrementellen Umformverfahren der Massivumformung zeichnen sich durch eine hohe Flexibilität aus, da die Prozesse gut anpassbar sind und die verwendeten Anlagen und Werkzeuge in einem geringeren Maße auf ein spezifisches Bauteil hin ausgelegt werden.Der hier vorgestellte Fügeprozess mittels Radial-Walzen ist geeignet, hybride Bauteile form- und kraftschlüssig miteinander zu verbinden. So lassen sich die spezifischen Vorteile verschiedener Werkstoffe kombinieren und Nutzungs- sowie Leichtbaupotenziale können gezielt genutzt werden. Die in diesem Prozess entstehende charakteristische umlaufende Kerbe in der Wellenkomponente bildet eine Schwachstelle der gefügten Bauteile, da es dort unter Last zu einer Spannungskonzentration kommt, welche die Bildung eines Risses begünstigt. Dieser Herausforderung wird mit einer Kombination der Ausnutzung der Kaltverfestigung des gewählten Werkstoffs (1.7225) und gezielt eingebrachter Druckeigenspannungen in der Kerbe begegnet. Hier liegt der Fokus auf den Druckeigenspannungen, die das Potenzial aufweisen, sich verlängernd auf die Lebensdauer auszuwirken. Sie lassen sich gezielt über eine günstige Wahl des Walzpfads zur Herstellung der Fügeverbindung beeinflussen, wie sowohl in numerischen Analysen als auch durch Eigenspannungsmessungen an Realbauteilen gezeigt wird. Es können sehr hohe Eigenspannungen in der kritischen Zone des Kerbgrunds eingebracht werden, die einen deutlichen Einfluss auf die Lebensdauer haben, wie auch die Lebensdauerberechnungen mittels des Örtlichen Konzepts deutlich zeigen.
Spatio-temporal movement patterns and habitat choice of red foxes (Vulpes vulpes) and racoon dogs (Nyctereutes procyonoides) along the Wadden Sea coast
Authors: Schwemmer Philipp , Weiel Stefan , Garthe Stefan 
Published: April 2021

AbstractWetlands such as the World Heritage Site in the Wadden Sea include important habitats for breeding waterbirds. Its saltmarshes and adjacent conservation polders are used by thousands of breeding birds. However, some alarming population declines have been recorded during recent decades and previous studies found indications that predation pressure from red foxes (Vulpes vulpes) and more recently from invasive racoon dogs (Nyctereutes procyonoides) played an important role. The current study aimed to assess habitat utilisation by foxes and racoon dogs along the coast of the Wadden Sea. We equipped 21 foxes and seven racoon dogs with GPS collars and recorded a total of 37,586 (mean: 2,088) GPS fixes during a total of 2,617 (mean: 145) equipment days for red foxes and 3,440 (mean: 573) GPS fixes during a total of 272 (mean: 45) equipment days for racoon dogs. Foxes showed high individual variability in Kernel 95% home range sizes, with a mean of 172.2 ha (range: 3 to 824 ha) and little overlap among territories. Males had significantly larger home ranges than females, and there were no differences in home range sizes between adults (n = 14) and young (n = 4). Racoon dogs had smaller home ranges than foxes (mean: 52.8 ha). The preferred habitat type of both predators during daytime was the conservation polders along the Wadden Sea, while foxes also selected saltmarshes during the night. In contrast, both species avoided farmland areas. Foxes showed 20% of their activity during daylight hours and spent this time largely in areas with dense vegetation cover. None of the tagged individuals entered areas with particularly high bird densities (i.e. Wadden Sea islands or Halligen). However, our data suggest that foxes and racoon dogs frequently make use of linear structures such as dykes and dams and patrol along the tide line for carcasses. This suggests that at least single individuals of both species are prone to enter islands that are connected by dams to the mainland.
Neratinib + capecitabine sustains health-related quality of life in patients with HER2-positive metastatic breast cancer and ≥ 2 prior HER2-directed regimens
Authors: Moy Beverly , Oliveira Mafalda , Saura Cristina , Gradishar William , Kim Sung-Bae , Brufsky Adam , Hurvitz Sara A. , Ryvo Larisa , Fagnani Daniele , Kalmadi Sujith , Silverman Paula , Delaloge Suzette , Alarcon Jesus , Kwong Ava , Lee Keun Seok , Ang Peter Cher Siang , Ow Samuel Guan Wei , Chu Sung-Chao , Bryce Richard , Keyvanjah Kiana , Bebchuk Judith , Zhang Bo , Oestreicher Nina , Bose Ron , Chan Nancy 
Published: April 2021

Abstract
Purpose
To characterize health-related quality of life (HRQoL) in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) from the NALA phase 3 study.

Methods
In NALA (NCT01808573), patients were randomized 1:1 to neratinib + capecitabine (N + C) or lapatinib + capecitabine (L + C). HRQoL was assessed using seven prespecified scores from the European Organisation for Research and Treatment of Cancer Quality Of Life Questionnaire core module (QLQ-C30) and breast cancer-specific questionnaire (QLQ-BR23) at baseline and every 6 weeks. Descriptive statistics summarized scores over time, mixed models evaluated differences between treatment arms, and Kaplan–Meier methods were used to assess time to deterioration in HRQoL scores of ≥ 10 points.

Results
Of the 621 patients randomized in NALA, patients were included in the HRQoL analysis if they completed baseline and at least one follow-up questionnaire. The summary, global health status, physical functioning, fatigue, constipation, and systemic therapy side effects scores were stable over time with no persistent differences between treatment groups. There were no differences in time to deterioration (TTD) for the QLQ-C30 summary score between treatment arms; the hazard ratio (HR) for N + C vs. L + C was 0.94 (95% CI 0.63–1.40). Only the diarrhea score worsened significantly more in the N + C arm as compared to the L + C arm, and this remained over time (HR for TTD for N + C vs. L + C was 1.71 [95% CI 1.32–2.23]).

Conclusion
In NALA, patients treated with N + C maintained their global HRQoL over time, despite a worsening of the diarrhea-related scores. These results may help guide optimal treatment selection for HER2-positive MBC.
Symposium report: breast cancer in India—trends, environmental exposures and clinical implications
Authors: McDonald Jasmine A. , Rao Roshni , Gibbons Marley , Janardhanan Rajiv , Jaswal Surinder , Mehrotra Ravi , Pandey Manoj , Radhakrishnan Venkatraman , Ramakant Pooja , Verma Nandini , Terry Mary Beth 
Published: April 2021

Abstract
Purpose
Incidence of breast cancer (BC), particularly in young women, are rising in India. Without population-based mammography screening, rising rates cannot be attributed to screening. Investigations are needed to understand the potential drivers of this trend.

Methods
An international team of experts convened to discuss the trends, environmental exposures, and clinical implications associated with BC in India and outlined recommendations for its management.

Results
Panels were structured across three major BC themes (n = 10 presentations). The symposium concluded with a semi-structured Think Tank designed to elicit short-term and long-term goals that could address the challenges of BC in India.

Conclusion
There was consensus that the prevalence of late-stage BC and the high BC mortality rates are associated with the practice of detection, which is primarily through clinical and self-breast exams, as opposed to mammography. Triple-Negative BC (TNBC) was extensively discussed, including TNBC etiology and potential risk factors, the limited treatment options, and if reported TNBC rates are supported by rigorous scientific evidence. The Think Tank session yielded long-term and short-term goals to further BC reduction in India and included more regional etiological studies on environmental exposures using existing India-based cohorts and case–control studies, standardization for molecular subtyping of BC cases, and improving the public’s awareness of breast health.
A global reconnaissance of particulates and metals/metalloids in untreated drinking water sources
Authors: Peterson Jonathan W. , Fry Benjamin M. , Wade Daniel R. , Fishman Ford J. , Stid Jacob T. , Peterson Jonas M. , Tarp Cleveland E. , Wade Randall D. , Brokus Sarah A. , Pikaart Michael J. , Krueger Brent P. , Best Aaron A. 
Published: April 2021

AbstractMetal and metalloid contamination in drinking water sources is a global concern, particularly in developing countries. This study used hollow membrane water filters and metal-capturing polyurethane foams to sample 71 drinking water sources in 22 different countries. Field sampling was performed with sampling kits prepared in the lab at Hope College in Holland, MI, USA. Filters and foams were sent back to the lab after sampling, and subsequent analysis of flushates and rinsates allowed the estimation of suspended solids and metal and other analayte concentrations in source waters. Estimated particulate concentrations were 0–92 mg/L, and consisted of quartz, feldspar, and clay, with some samples containing metal oxides or sulfide phases. As and Cu were the only analytes which occurred above the World Health Organization (WHO) guidelines of 10 μg/L and 2000 μg/L, respectively, with As exceeding the guideline in 45% of the sources and Cu in 3%. Except for one value of ~ 285 μg/L, As concentrations were 45–200 μg/L (river), 65–179 μg/L (well), and 112–178 μg/L (tap). Other metals (Ce, Fe, Mg, Mn, Zn) with no WHO guideline were also detected, with Mn the most common. This study demonstrated that filters and foams can be used for reconnaissance characterization of untreated drinking water. However, estimated metal and other analyte concentrations could only be reported as minimum values due to potential incomplete retrieval of foam-bound analytes. A qualitative reporting methodology was used to report analytes as “present” if the concentration was below the WHO guideline, and “present-recommend retesting” if the concentration was quantifiable and above the WHO guideline.
Belief adjustment: a double hurdle model and experimental evidence
Authors: Henckel Timo , Menzies Gordon D. , Moffatt Peter G. , Zizzo Daniel J. 
Published: April 2021

AbstractWe present an experiment where subjects sequentially receive signals about the true state of the world and need to form beliefs about which one is true, with payoffs related to reported beliefs. We attempt to control for risk aversion using the Offerman et al. (Rev Econ Stud 76(4):1461–1489, 2009) technique. Against the baseline of Bayesian updating, we test for belief adjustment underreaction and overreaction and model the decision making process of the agent as a double hurdle model where agents with inferential expectations first decide whether to adjust their beliefs and then, if so, decide by how much. We also test the effects of increased inattention and complexity on belief updating. We find evidence for periods of belief inertia interspersed with belief adjustment. This is due to a combination of random belief adjustment; state-dependent belief adjustment, with many subjects requiring considerable evidence to change their beliefs; and quasi-Bayesian belief adjustment, with aggregate insufficient belief adjustment when a belief change does occur. Inattention, like complexity, makes subjects less likely to adjust their stated beliefs, while inattention additionally discourages full adjustment.
Qualitative Differences in Attribution of Mental States to Other People in Autism and Schizophrenia: What are the Tools for Differential Diagnosis?
Authors: Mazza Monica , Pino Maria Chiara , Keller Roberto , Vagnetti Roberto , Attanasio Margherita , Filocamo Angela , Le Donne Ilenia , Masedu Francesco , Valenti Marco 
Published: April 2021

AbstractThe differential diagnosis between schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD) remains an important clinical question, because they have overlap in clinical diagnosis. This study explored the differences between ASD (n = 44) and SSD patients (n = 59), compared to typically developing peers (n = 63), in completing an advanced Theory of Mind (ToM) task. The outcome found several differences between groups. The SSD patients showed greater difficulty in understanding social scenarios, while ASD individuals understood the stories, but did not correctly identify the protagonist’s intention. The interesting aspect of the results is that some ToM stories are more informative about the mentalistic reasoning of the two clinical groups, namely, the stories that investigate pretend, persuasion, double bluff and ironic joke constructs.
The Role of Emotional Regulation in Anxiety and Depression Symptom Interplay and Expression among Adolescent Females
Authors: McGlinchey Emily , Kirby Karen , McElroy Eoin , Murphy Jamie 
Published: April 2021

AbstractDepression and anxiety are highly comorbid constructs. However little is known about the mechanisms that underpin this comorbidity/connectivity or the divergence between constructs that seems to occur in adolescence. The current study targeted emotion regulation (ER) as a potential plausible mechanism for explaining how anxiety and depression symptoms in adolescence might begin to connect, perpetuate, and ultimately diverge from one another. Using data from a cross-sectional school-based study, of adolescent females (age 11–18 years; N = 615; majority were white (97.7%)), we modelled variation in ER using latent profile analysis. Then, using network analysis (NA), we generated separate depression-anxiety symptom networks for adolescents at varying levels of ER. Three latent classes of ER were identified (low ER 15%, intermediate ER 34%, high ER 51%). The results of the network comparison test found no significant differences in global strength between the ‘low ER’ and the ‘intermediate ER’ ability network. This study is among the first to attempt to model change in depression-anxiety symptom connectivity in adolescence in relation to a common contextual/risk factor. The current study therefore offers a unique contribution to the examination of the role of transdiagnostic factors in the study of adolescent depression and anxiety from a network perspective, and provides a promising framework for the study of ER among anxiety and depression symptomatology in adolescence.
Convolution-based time-domain simulation for fluidelastic instability in tube arrays
Authors: Zhang Mingjie , Øiseth Ole 
Published: April 2021

AbstractA convolution-based numerical algorithm is presented for the time-domain analysis of fluidelastic instability in tube arrays, emphasizing in detail some key numerical issues involved in the time-domain simulation. The unit-step and unit-impulse response functions, as two elementary building blocks for the time-domain analysis, are interpreted systematically. An amplitude-dependent unit-step or unit-impulse response function is introduced to capture the main features of the nonlinear fluidelastic (FE) forces. Connections of these elementary functions with conventional frequency-domain unsteady FE force coefficients are discussed to facilitate the identification of model parameters. Due to the lack of a reliable method to directly identify the unit-step or unit-impulse response function, the response function is indirectly identified based on the unsteady FE force coefficients. However, the transient feature captured by the indirectly identified response function may not be consistent with the physical fluid-memory effects. A recursive function is derived for FE force simulation to reduce the computational cost of the convolution operation. Numerical examples of two tube arrays, containing both a single flexible tube and multiple flexible tubes, are provided to validate the fidelity of the time-domain simulation. It is proven that the present time-domain simulation can achieve the same level of accuracy as the frequency-domain simulation based on the unsteady FE force coefficients. The convolution-based time-domain simulation can be used to more accurately evaluate the integrity of tube arrays by considering various nonlinear effects and non-uniform flow conditions. However, the indirectly identified unit-step or unit-impulse response function may fail to capture the underlying discontinuity in the stability curve due to the prespecified expression for fluid-memory effects.