bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging HEOR Services for Drug Development and Market Access in the GCC
Authors: Sabbagh Dit Hawasli Racha 
Published: December 2024

Abstract
Health economics and outcomes research (HEOR) services play a pivotal role in optimizing research capabilities across healthcare economics, patient outcomes, and policy development. In the Gulf Cooperation Council (GCC) region, applying HEOR principles is essential for driving the pharmaceutical industry toward cost-effective, patient-centered healthcare solutions. The objectives of this commentary are to describe the current trends in HEOR initiatives within the GCC and to highlight related gaps requiring resolution. By supporting drug development and market access, HEOR aids both pharmaceutical companies and payers in crafting sustainable healthcare models that enhance patient access to innovative treatments and contribute to the formulation of resilient healthcare policies. HEOR is also instrumental in assessing advancements in genetics and precision medicine, enabling personalized treatment strategies that optimize therapeutic efficacy based on individual genetic profiles. Additionally, by supporting public and private initiatives, HEOR is committed to promoting equitable access to medical innovations, ensuring that all population segments benefit from novel treatments, irrespective of socioeconomic status. The ultimate goal of HEOR is to drive the adoption of value-based healthcare, a transition that health systems across the Middle East and North Africa region are navigating at different stages, often hindered by barriers requiring resolution at the national level. The core gaps include a shortage of local data and evidence, a low HEOR publication rate, insufficient expertise, and paucity of collaboration.
Juvenile trabecular ossifying fibroma of maxilla
Authors: Abbas Rezhat , Latoo Suheel Hamid , Dar Mohammad Shafi , Gowhar Owais 
Published: December 2024

Abstract
Ossifying fibroma is a rare tumor formed by abnormal cells in the ligament. There are two types of ossifying fibroma: central and peripheral. A 20-year-old female patient experienced pain and swelling on the right side of her face for one year. On intraoral examination, there was diffuse, ill-defined swelling on the right maxillary alveolus, which also involved the cheek. An excisional biopsy was carried out and histopathological findings indicated juvenile trabecular ossifying fibroma. Juvenile ossifying fibroma is a rare, benign childhood tumor known for its rapid and sporadic growth, which can cause morphologic abnormalities and, in some cases, functional deterioration. Regular and long-term follow-up is essential because of its recurrence.
Revolutionizing oral health care: The promise of terahertz radiation for oral oncological lesions
Authors: AlSabbag Alice , Al-Raeei Marwan 
Published: December 2024

Abstract
Terahertz (THz) radiation offers nondestructive, nonionizing treatment for medical conditions like tumors and dental diseases. With recent technological advances, it shows promise in accurate imaging, diagnosis, and treatment, especially in oral and dental oncology. Its potential in oral health care is vast and groundbreaking. In the field of oral medicine and oncology, oral lesions present a significant challenge in diagnosis and treatment. Common types of lesions include fibromas, mucoceles, periodontal cysts, dentigerous cysts, root cysts, and osteonecrosis of the jaws. Conventional treatments for these lesions often involve invasive procedures with potential side effects. However, the use of THz waves as a diagnostic and treatment approach shows promise in providing safer and more effective solutions. By leveraging the unique properties of THz photons and developing advanced amplification techniques, THz waves can target specific lesions with precision, minimizing damage to surrounding healthy tissues. Continued research and technological advancements in this area have the potential to revolutionize the management of oral lesions and tumors. Utilizing THz radiation for lesion therapy, we can target lesions with precision based on their unique dissociation energy. This approach minimizes harm to surrounding tissues, making it a safer alternative to ionizing radiation like X-rays. The nonionizing nature of THz radiation reduces the risk of side effects such as cell damage and cancer development. Further research is needed to fully understand the effectiveness and safety of THz therapy for various tumors. Safety precautions, proper training, and ethical considerations are essential when working with THz radiation. By approaching this technology with caution and ethical awareness, we can maximize its benefits while ensuring safety and responsible use.
Acute dental pain and the different management methods among adults in Taif, Saudi Arabia: A cross-sectional study
Authors: Shukr Bandar S. , Mandorah Ayman , Altalhi Faisal K. , Alqurashi Yousef A. , Shawli Hassan T. , Alqarni Ali A. , Alzubaidi Mohammed A. 
Published: December 2024

Abstract

Introduction:
One of the most common reasons for visiting dental clinics is dental pain. Seeking timely and professional dental care is a crucial step to maintain good oral health.

Aims:
The aim of the present study was to explore the prevalence of acute dental pain, the different management methods, and the use and practicality of teledentistry and online dental consultations among the population of Taif, Saudi Arabia.

Materials and Methods:
A total of 556 adults were enrolled in the study by answering an online survey that was distributed through different social media websites. Data were collected on the type of dental pain, pain-related characteristics using the Modified Dental Pain Screening Questionnaire, self-and formal care methods for pain relief, and the utilization of teledentistry services. Data analysis was performed using descriptive statistics, the Chi-square test, and the logistic regression model.

Results and Discussion:
Of the 556 participants, approximately 68% reported having dental pain, and almost 39% reported that the pain originated from a tooth. In addition, 73.2% reported that the pain was exacerbated after eating/drinking something cold. Regarding self-care methods, prescribed drugs were found to be mostly taken by those aged 41–50 years (adjusted odds ratio [AOR] = 3.38, P = 0.01), whereas nonprescribed drugs and home remedies were mostly taken by those aged 51 years or older (AOR = 2.25, P = 0.02; AOR = 2.65, P = 0.007; respectively). For formal-care methods, those who obtained professional help to control their pain were more likely to be dentists/dental students (AOR = 6.17, P = 0.02). Furthermore, a borderline effect was observed regarding teledentistry usage, with most users who were connected to a dentist being 31–40 years old (P = 0.09) and less likely to be men (P = 0.08).

Conclusion:
The prevalence of acute dental pain and self-medication practices was notably high among the study population. Therefore, it is imperative to educate the general public on appropriate management strategies for this type of pain. In addition, the utilization of teledentistry services was minimal within this population.
Perception of Student-Facilitated Problem-Based Learning in Integrated Basic Medical Sciences: A Retrospective Qualitative Analysis of Academic Records
Authors: Joshi Dr. Lok Raj , Nembang Penchha , Hamal Deependra , Thakur Chandan , Anu Anuraj , Bist Binamra 
Published: December 2024

Background
Problem-based learning (PBL) fosters critical thinking, problem solving and social skills Experienced faculty tutors for PBL are difficult to manage in resource-limited settings. This study aimed to assess the effectiveness and shortcomings of student-facilitated PBL in such a setting in Nepal.
Methods
Medical students of the MBBS first year and the second year carried out student-facilitated PBL modules in Karnali Academy of Health Science, Jumla during March and April of 2024. Our observational study adopted retrospective analysis using both quantitative and qualitative tools. This report presents the qualitative component including the analysis of the perceptions or experiences of the students and faculty. The data comprised of the presentation slides of the student teams during wrap-up seminars and notes taken during group discussions of the students and faculty members after the PBL modules. Reflexive thematic analysis of reports of subjective experience of students and faculty members were carried out and narrative accounts were prepared.
Results
Most of the students and faculty valued the student-facilitated PBL modules positively. More self-directed nature, in-depth study, hesitation-free discussions and development of problem-solving and leadership skills were among the perceived advantages of the PBL modules. Major challenges were related to inadequacy of the PBL process skills, team management and time management issues.
Conclusions
The student-facilitated PBL module was effective for acquiring content knowledge as well as problem solving and leadership skills. Both students and faculty members felt the need of further training to the students regarding the PBL process.
SINERGITAS TNI AD DENGAN PEMERINTAH KOTA DALAM IMPLEMENTASI PROGRAM TENTARA MANUNGGAL MASUK DESA (TMMD) DI KOTA PEKANBARU
Authors: Hutagalung Parlindungan , Yuliani Febri 
Published: December 2024

Program TMMD secara umum dalam UU TNI diartikan sebagai membantu tugas pemerintahan di daerah, yakni bagian dari komitmen TNI Angkatan Darat untuk ikut membangun bangsa dan negara bersama komponen bangsa lainnya (dalam hal ini TNI bekerja sama dengan Kementerian Desa, Pembangunan Daerah Tertinggal dan Transmigrasi bersama seluruh jajarannya) secara sinergi dan berkesinambungan.Penelitian ini bertujuan untuk menganalisis sinergitas TNI AD dengan Pemerintah Kota dalam implementasi Program Tentara Manunggal Masuk Desa (TMMD) di Kota Pekanbaru.beserta kendala yang dihadapi Ketika pelaksanaan, dengan menggunakan metode penelitian kualitatif dan analisis data miles Huberman untuk menganalisis permasalahan. Sehingga hasil penelitian ini menyebutkan bahwa telah berjalan efektif dengan dukungan yang baik dari masyarakat. Meskipun demikian, terdapat kendala seperti kesulitan dalam mobilisasi partisipasi masyarakat lokal tanpa mengganggu mata pencaharian mereka, serta kurangnya kesadaran dan pengetahuan tentang TMMD di kalangan masyarakat. Pihak TNI AD dan Pemerintah Kota Pekanbaru menunjukkan komitmen untuk mengatasi kendala ini dengan memanfaatkan evaluasi dan umpan balik dari pelaksanaan TMMD, termasuk melalui pendekatan non-fisik seperti penyuluhan untuk meningkatkan pemahaman masyarakat dan menyelesaikan konflik internal yang muncul.
A Comparison Study of Garlic and Propolis Extract as Biological Activity on Staphylococcus aureus Isolated from Diabetic Foot Patients
Authors: Ghazal Sabreen G. , Gihad Zeena Kareem , Saad Hanan 
Published: December 2024

Background: Plant extracts play a crucial role in biological activity in recent years the extraction of some active material from some plants indicates good activity challenging the excess types of bacteria without side effects. Methods: Simple extraction is used to extract garlic using water as a solvent and ethanol for propolis. the Garlic and Propolis extract used on the Staphylococcus aureus which was isolated and identified from diabetic foot patients after culturing the bacteria on Mullar Hinton media the biological activity was measured for the Garlic and Propolis extract. Results: The elevated concentration of the garlic extracts (C) produced elevated inhibition by S. aureus (32 mm); the smallest inhibition zone was detected by Staphylococcus aureus (19 mm) in the minimal concentration of the garlic extracts. While the elevated concentration of the propolis extracts produced the elevated inhibition zone by S. aureus (20mm), the smallest inhibition zone (14mm) was detected by Staphylococcus aureus in the low concentration of propolis extract. The inhibition zone of the garlic extracts (at 5% concentration) was the larger than the propolis extract at 5g\ml against S. aureus (32 vs 20 mm). The MIC method by S. aureus of the garlic extract resulted 12.5 mg/ml, while, the propolis extract resulted 3.2 mg/ml. The MBC recognized by the lack the growth of the tested bacteria that inoculated from the inhibition well initial from the maximum concentration (100 mg/ml) reached to the concentration equivalent the minimal MIC. The garlic extract exhibited an absence growth of bacteria for total inoculation which confirmations potentially bactericidal action to S. aureus have an MBC at 12.5 mg/ml. Conclusion: The elevated concentration of the garlic extracts produced the elevated inhibition towards S. aureus as well as the least inhibition zone detected in the minimal concentration of the garlic extracts towards Staphylococcus aureus. Whatever the concentration of the garlic extracts used in the present study, the inhibition zone was larger as compared with propolis. The results indicate that the garlic extract was more active than the propolis extract. The results prove the efficiency of garlic extract, which makes them suitable for medical treatment used as an ointment form or tablet to treat ulcers suffered by patients with chronic diabetes.
Enhancing the Handling of Digital Evidence in Ukraine's Criminal Justice System
Authors: Varenia Nataliia , Мoskvych Lidiia , Olkhovskyi Oleksandr , Lykhoshapko Dmytro , Aloshyn Oleksandr 
Published: December 2024

Purpose: The article analyses investigative and judicial practice aspects, recognising the admissibility of electronic (digital) evidence in criminal proceedings.

Design/Methodology/Approach: During the work, a comprehensive study of electronic evidence's theoretical and applied aspects in criminal proceedings was conducted, highlighting their features and place in the procedural sources of evidence.

Research Limitation/Implications: It has been established that the electronic format of evidence creates specific difficulties in the context of their establishment as evidence. Special attention in the research is given to proving based on electronic evidence. It is substantiated that information obtained from digital carriers can be used to construct investigative versions, identify criminal connections, and, in some cases, confirm the facts of a crime. It has been proven that information significant for criminal proceedings can be in electronic documents, photos, audio or video recordings, and arrays of informative data regarding databases, registry operations, telecommunication networks, etc.

Social Implication: The process of proving forms the basis of pre-trial investigation, starting from entering information into the Unified Register of Pre-trial Investigations and up to the decision-making in criminal proceedings.

Practical Implication: The article summarises contemporary scientific developments regarding the definition and essence of electronic evidence and examines the phenomenon of “electronic (digital) evidence” in criminal proceedings. It substantiates the norms of legal and legislative regulation of the process of using electronic evidence in criminal proceedings.

Originality/Value: The research is dedicated to analysing the prospects for improving the work with evidence in electronic form in the criminal process of Ukraine.
Achieving Sustainable Development Goals: Exploring the Influence of Live Shopping Behavior on Purchase Intentions in “Tiktok” Shop
Authors: Herlina  , Haryanto Budhi , Wahyudi Lilik , Sugiarto Catur 
Published: December 2024

Objectives: This study explores the influence of live shopping behavior on consumer purchase intentions within the TikTok Shop, emphasizing its relevance to achieving Sustainable Development Goals (SDGs). Understanding the dynamics of live shopping behavior on platforms like TikTok is vital for businesses aiming to leverage this innovative marketing strategy.

Theoretical framework: The research is grounded with a behavioral predictor in understanding shopping decisions using the Stimulus-Organism-Response (S-O-R) theory psychological model. SOR here, the stimulus uses store and brand image; the organism sees from quality and trust, and the response is based on purchase intention.

Methods: Sample data was obtained from 419 respondents from an online survey using the snowball technique. Data were analyzed using partial least squares structural equation modeling (PLS-SEM) to test the proposed hypotheses

Results and discussion: Brand image affects perceived quality, and brand image affects trust. Store image affects perceived quality, and store image affects trust. Perceived quality and trust affect purchase intention.

Research Implications: The findings can be used as an evaluation for a marketing platform tool for the purchasing decision-making process. The development of the live shopping research model framework with Stimulus-Organism-Response (S-O-R) theory effectively for evaluating consumer and online shopping behavior. Meanwhile, this research also provides managerial strategies related to insights to managers of online shopping services, especially for e-commerce to be able to develop business networks by paying attention to factors that influence consumer behavior in online shopping, which will impact consumer buying interest

Originality/Value: This research gives insight to behavior literature which focus on the Stimuli-Organism-Response (SOR) theory as a review tool for the purchase decision-making process and consumer behavior. In addition, evaluating consumers' online shopping behavior (TikTok Shop) developed a robust online consumer behavior concept on the influence of variables used to measure live shopping behavior in making decisions on consumer purchase intention.
Public-Private Partnerships as a Catalyst for Sustainable Development
Authors: Budnyk Viktoriia , Vasylieva Nadiia , Artemenko Anton , Shcherbak Viktor , Kapelista Iryna 
Published: December 2024

Objective: The aim of the article is to analyze the role of public-private partnerships (PPPs) in the context of promoting sustainable development, social inclusion, economic growth, and environmental protection.

Theoretical Framework: The relevance of the synergy between public and private resources is intensified by the potential of public-private partnerships to promote sustainable development. By combining the functional advantages of public authorities with the capabilities of private business structures, PPPs allow for the most efficient allocation of resource potential. They help solve a range of problems through the integration of innovative approaches, leading to the successful implementation of strategic, socially significant projects.

Methods: The study analyses the existing model of public-private partnerships in the European environment, with a focus on the main problems and bottlenecks in the traditional system of partnership between the business sector and government. A comparative analysis is carried out between the priority trends in PPP development in Europe and the national realities in Ukraine.
Results: The study confirms that involving the private business sector provides projects with necessary resource support, innovative efficiency, and technical expertise, which accelerates the implementation of key public initiatives. PPPs contribute to the sustainable development of critical infrastructure, facilitating economic diversification and sustainable human development.

Contribution: The research demonstrates that public-private partnerships create a favourable environment for investment and entrepreneurship, offering a stable management framework for successful projects.

Originality/Value: This article provides valuable insights into the role of PPPs in enhancing socio-economic security and promoting sustainable development, particularly within European and Ukrainian contexts.
Rugby inclusivo con personas con discapacidad intelectual: la opinión de los representantes de los clubes en España
Authors: Fernández-Zamarro Irene , Pérez-Rodriguez Marta , Redondo-Fernández Aurea , Archilla-Prat César , Perez Tejero Javier 
Published: December 2024

Introducción: el rugby inclusivo con personas con discapacidad intelectual es uno de los deportes más innovadores y en auge en España. En 2019, la Federación Española de Rugby (FER) aprobó el Plan Nacional de Rugby Inclusivo, diseñando estructuras y regulaciones para dar lugar a las personas con discapacidad intelectual que quisieran practicar rugby.
Objetivo: este estudio tuvo como objetivo conocer la situación de las personas con DI en los clubes de rugby españoles que cuentan con actividades para este colectivo, a través de la opinión de los representantes de dichos clubes.
Metodología: para esto, todos representantes de los clubes y asociaciones de rugby españoles fueron invitados a un encuentro estatal para discutir sobre estos dos temas, debiendo rellenar una encuesta sobre el proceso de inclusión de estas personas en los clubes. Finalmente, fueron 34 clubes los que completaron el formulario a través de sus representantes.
Resultados: tras su análisis, las temáticas emergentes principales fueron la importancia de la visibilidad y la promoción del rugby inclusivo.
Discusión: en línea con otros estudios de este ámbito, se hace patente la necesidad de disponer de diferentes herramientas (económicas y sociales) para poder generar contextos de inclusión en los clubes de rugby españoles.
Conclusiones: se concluyó que la participación de las personas con discapacidad intelectual en los juegos o actividades de rugby es limitada debido a los impedimentos detectados (como lo es la formación de los profesionales sobre rugby para incluir a personas con discapacidad intelectual), destacando la importancia de promover esta modalidad en España.
Estudio mixto sobre la gamificación y su efecto en la motivación: Metodologías participativas en el contexto universitario
Authors: Edo Esther 
Published: December 2024

La inclusión de metodologías participativas en el aula que favorezcan la interacción entre diferentes agentes educativos y, por consiguiente, el enriquecimiento mutuo entre estudiantes es uno de los ejes pedagógicos impulsados desde la actual legislación educativa, como también lo es la adaptación de los procesos de enseñanza-aprendizaje a las necesidades e intereses del alumnado. La motivación es un factor vinculado a estas demandas educativas que a su vez ha sido, y continúa siendo, objeto de estudio en la investigación educativa. El presente trabajo tiene como objetivo analizar el efecto de la metodología de la Gamificación sobre la motivación del alumnado universitario en su formación inicial docente (N=95). Se trata de un estudio mixto cuasi-experimental, cuyos resultados, derivados de los análisis cuantitativos y cualitativos, demuestran que la motivación experimenta mejora significativa en el alumnado universitario. El valor añadido de esta investigación radica en los factores asociados a dicho incremento como por ejemplo las mecánicas lúdicas como las tablas de clasificación, las dinámicas como la competición, las interacciones entre iguales, la introducción semanal de nuevas estrategias didácticas y los cambios de agrupamiento del alumnado, entre otros. Además, especial interés aporta el estudio por tratarse de un ejemplo de Gamificación de estructura desarrollado en una asignatura del plan de estudios de magisterio que aporta evidencia de carácter no solo cualitativo, si no también cuantitativo sobre los beneficios de la Gamificación aplicada en el contexto universitario.