bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender Ideologies and Polish Political Parties
Authors: Gwiazda Anna 
Published: December 2021

AbstractThis article explores the gender dimension of ideology and representation by analysing the political parties that ran in the 2019 Polish parliamentary elections, using a novel analytical framework based on gender claims and gender-related policy pledges. This article demonstrates that a left and liberal ideology largely determines feminist and pro-LGBTQ+ promissory representation. However, the gender ideologies of right-wing political parties vary in their traditional types and can include a populist element. This article contributes to comparative gender and politics scholarship by examining gender ideologies in the Central and Eastern European context, where on the one hand, populism and anti-gender campaigns have taken hold, and, on the other, feminist and progressive movements have challenged traditionalism and illiberalism. This article also differentiates a scholarly meaning of gender ideology from its populist meaning.
Plasma vitamin B12 concentration is positively associated with cognitive development in healthy Danish 3-year-old children: the SKOT cohort studies
Authors: Larnkjær Anni , Christensen Sophie H. , Lind Mads V. , Michaelsen Kim F. , Mølgaard Christian 
Published: December 2021

AbstractAdequate vitamin B12 (B12) and folate concentrations are essential for neural development in early childhood, but studies in well-nourished children are lacking. We investigated the relation between plasma B12 and folate at 9 and 36 months and psychomotor development at 36 months in well-nourished Danish children. Subjects from the SKOT cohorts with B12 measurement and completed Ages and Stages Questionnaire, 3rd edition (ASQ-3) at 36 months were included (n 280). Dietary intake, B12 and folate concentrations were collected at 9 and 36 months, and ASQ-3 was assessed at 36 months. Associations between B12 and folate at 9 and 36 months and ASQ-3 were analysed using regression models. Associations between diet and B12 were also investigated. No children had insufficient B12 (<148 pmol/l) at 36 months. B12 at 36 month was positively associated with total ASQ-3 corresponding to an increase of 100 pmol/l B12 per 1·5 increase in total ASQ-3 score (P = 0·019) which remained significant after adjustment for potential confounders including 9 months values. B12 at 9 months or folate at any time point was not associated with total ASQ-3. Intake of milk products was associated with B12 at 36 months (P = 0·003) and showed a trend at 9 months (P = 0·069). Intake of meat products was not associated with B12. In conclusion, B12 was positively related to psychomotor development at 3 years in well-nourished children, indicating that the impact of having marginally low B12 status on psychomotor development in well-nourished children should be examined further.
Who are the 3 Per Cent? The Connections Among Climate Change Contrarians
Authors: Young Laura D. , Fitz Erin B. 
Published: December 2021

AbstractDespite 97 per cent of scientists agreeing on anthropogenic global warming, the remaining 3 per cent play a critical role in keeping the debate about climate consensus alive. Analysis of climate change contrarians from multi-signatory documents reveals 3 per cent of signees to be climate experts, while the remaining 97 per cent do not meet expert criteria and are also involved with organizations and industries who make up the climate change countermovement. The data also reveal most contrarians to be aged sixty-five or older. As a result, we explore other factors (for example, collective memories and ideological views) that may have also contributed to expert and non-expert views.
Prenatal predictors of childhood anxiety disorders: An exploratory study of the role of attachment organization
Authors: Galbally Megan , Watson Stuart J. , van IJzendoorn Marinus H. , Tharner Anne , Luijk Maartje , de Kloet E. Ron , van Rossum Elisabeth F.C. , Lewis Andrew J. 
Published: December 2021

AbstractChildhood anxiety disorders (CAD) are a common childhood mental disorder and understanding early developmental pathways is key to prevention and early intervention. What is not understood is whether early life stress predictors of CAD might be both mediated by infant cortisol reactivity and moderated by infant attachment status. To address this question, this exploratory study draws on 190 women recruited in early pregnancy and followed together with their children until 4 years of age. Early life stress is operationalized as maternal depression measured using the Structured Clinical Interview for the DSM, Childhood Trauma Questionnaire, Parenting Stress Index, and antenatal maternal hair cortisol concentrations. Infant cortisol reactivity was measured at 12 months together with the Strange Situation Procedure and CAD assessed at 4 years of age using the Preschool Age Psychiatric Assessment. There was no direct association between attachment classification and CAD. Furthermore, infant cortisol reactivity neither mediated nor attachment moderated the association of early life stress predictors and CAD. However, only for infants with organized attachment classifications, higher maternal antenatal depression, and hair cortisol were associated with a higher risk of CAD.
A Demodulation Algorithm for Periodically In-Plane Vibrating MEMS Based on a Stroboscopic Micro-Visual System
Authors: Yu Minhui , Sang Mei , Guo Cheng , Zhang Ruifeng , Zhao Fan , Liu Hongguang , Liu Tiegen 
Published: December 2021

AbstractA high-frequency short-pulsed stroboscopic micro-visual system was employed to capture the transient image sequences of a periodically in-plane working micro-electro-mechanical system (MEMS) devices. To demodulate the motion parameters of the devices from the images, we developed the feature point matching (FPM) algorithm based on Speeded-Up Robust Features (SURF). A MEMS gyroscope, vibrating at a frequency of 8.189 kHz, was used as a testing sample to evaluate the performance of the proposed algorithm. Within the same processing time, the SURF-based FPM method demodulated the velocity of the in-plane motion with a precision of 10−5 pixels of the image, which was two orders of magnitude higher than the template-matching and frame-difference algorithms.
Multilayer metallic filters for Q/V band IMUX
Authors: Steffè Walter , Vitulli Francesco 
Published: December 2021

AbstractCurrent designs of space IMUX filters are based on dual-mode circular waveguide cavities, on dielectric resonators or, at the lower end of the frequency spectrum, on coaxial resonators. This paper presents a new kind of IMUX filter aimed at high operating frequencies (Ka, Q, and V bands) which was developed in the frame of an ESA funded study named KALOS-DEVAQ. The new filter implements a quasi-elliptic frequency response and is characterized by simple geometry. The mechanical structure is composed of stacked metallic plates and it is well suited to be manufactured, at a low cost, with high accuracy. Despite the lower unloaded Q factor, the new configuration allows achieving a comparable flatness of insertion loss and group delay, thanks to the application of the pre-distortion technique. The increased insertion loss does not affect the system performances because it can be compensated by the amplification stages in the RF chain.
Tropical Cirrus in Global Storm‐Resolving Models: 2. Cirrus Life Cycle and Top‐of‐Atmosphere Radiative Fluxes
Authors: Turbeville S. M. , Nugent J. M. , Ackerman T. P. , Bretherton C. S. , Blossey P. N. 
Published: December 2021

AbstractCirrus clouds of various thicknesses and radiative characteristics extend over much of the tropics, especially around deep convection. They are difficult to observe due to their high altitude and sometimes small optical depths. They are also difficult to simulate in conventional global climate models, which have coarse grid spacings and simplified parameterizations of deep convection and cirrus formation. We investigate the representation of tropical cirrus in global storm‐resolving models (GSRMs), which have higher spatial resolution and explicit convection and could more accurately represent cirrus cloud processes. This study uses GSRMs from the DYnamics of the Atmospheric general circulation Modeled On Non‐hydrostatic Domains (DYAMOND) project. The aggregate life cycle of tropical cirrus is analyzed using joint albedo and outgoing longwave radiation (OLR) histograms to assess the fidelity of models in capturing the observed cirrus cloud populations over representative tropical ocean and land regions. The proportions of optically thick deep convection, anvils, and cirrus vary across models and are portrayed in the vertical distribution of cloud cover and top‐of‐atmosphere radiative fluxes. Model differences in cirrus populations, likely driven by subgrid processes such as ice microphysics, dominate over regional differences between convectively active tropical land and ocean locations.
Lithium Storage and Release From Lacustrine Sediments: Implications for Lithium Enrichment and Sustainability in Continental Brines
Authors: Coffey D. M. , Munk L. A. , Ibarra D. E. , Butler K. L. , Boutt D. F. , Jenckes J. 
Published: December 2021

AbstractDespite current and projected future reliance on lithium (Li) as a resource, deficiencies remain in genesis models of closed‐basin Li brines. Subsurface geochemical interactions between water and bulk solid phases from lacustrine sediments, are shown here to be the most important process for brine genesis and sustainability of the Clayton Valley, NV brine deposit. A new subsurface basin model was developed and used to select Li‐bearing solids to test the release mechanisms for Li. Ash (20–350 ppm Li) and bulk sediments (1,000–1,700 ppm Li) samples across depths in the basin represent the majority of the subsurface Li‐bearing materials. Temperature dependent (25°C–95°C) batch reaction experiments using low‐salinity groundwater from the basin indicate a positive relationship between the amount of Li released and temperature. Four‐step sequential extractions on a subset of bulk sediments indicate most Li is released from water and weak acid‐soluble portions with approximately 30% of the total Li contained in the sediments released overall. We conceptualize that Li is released from these samples via three mechanisms: (a) release of adsorbed Li; (b) cation exchange of Li and Mg and; (c) possible minor release from the silicate structure at elevated temperatures. Based on these results and the abundance of Li‐bearing sediments in the subsurface we estimate the mean Li mass in the basin materials to be between 24.4 and 58.0 Mt which provides a continuous supply from water‐rock interactions. This is now the largest known accumulation of Li in a basin‐fill continental setting on a global scale.
Heat Flow Distribution in the Chukchi Borderland and Surrounding Regions, Arctic Ocean
Authors: Zhang T. , Shen Z. Y. , Zhang F. , Ding M. 
Published: December 2021

AbstractFifty new heat flow measurements from the Chukchi Borderland (CBL) and adjacent regions of the central Arctic Ocean are reported, where heat flow measurements have been very limited. The average heat flow of the CBL (65 mW/m2) is significantly higher than that of the entire Amerasia Basin (53 mW/m2). In the CBL, the heat flow of the Chukchi Plateau (CP), Northwind Basin (NWB), and Northwind Ridge (NWR) are 64 mW/m2, 69 mW/m2, and 60 mW/m2, respectively. With the aid of nearby seismic profiles, the elevated regional heat flow in the CP and NWR was attributed to the enhanced radiogenic heating of the thick crust (25–29 km), while the most prominent heat flow in the relatively thin crust of the NWB is likely due to the residual heat of a major tectonic extension event. Further numerical heat conduction modeling suggests that the initial rifting of the Amerasia Basin during the Jurassic–Early Cretaceous could not induce such high heat flow in the NWB. Together with recent interpretations of seismic profiles, the elevated heat flow in the NWB could be explained by the residual heat of the Late Cretaceous–early Cenozoic extension. This extension event was contemporaneous with the seafloor spreading in the Makarov Basin and had also been associated with the onset of seafloor spreading in the Eurasia Basin.
The Response of the D and E Regions of the Equatorial Ionosphere to Solar Flare Events
Authors: Gopika P. G. , Ambili K. M. , Choudhary R. K. 
Published: December 2021

AbstractUsing measurements from a ground‐based magnetometer and an in‐house developed quasi‐two‐dimensional theoretical ionospheric model (QTD), the differential response of D and E regions of the equatorial ionosphere to the solar flare events which occurred on 20 February 2002 (M1.5 class), and 24 September 2011 (X1.9 class) has been investigated. The ground‐based magnetometer at Tirunelveli (8.71°N, 77.75°E, 2.9°S dip latitude) was used to monitor variations in the magnetic field (ΔH) during the two events. An abrupt increase in ΔH [positive Solar Flare Effect (SFE)] was noted during both the flare events, a signature of the prompt response to the flare. The ΔH, however, was seen to get weakened (reversed SFE) on 20 February 2002 at a time delay of about 10 min post flare peak. The weakening in ΔH happened during local noon (∼11:30 LT), a period when there was no sign of the counter electrojet (CEJ). The QTD model was used to simulate the ratio of field line integrated Hall to Pedersen conductivity and variations in the east–west currents during the flare events. Model simulations show differential response in the conductivity ratio at the D and E‐regions of the ionosphere during the period when the ionospheric current system was undergoing alternations manifesting as ΔH variations in the ground‐based magnetometer observations. We show that in addition to the changes in conductivity during a solar flare, the electric field variations also modulate ionospheric currents to produce differential footprints in ΔH as positive/negative SFE, SFE*, or reversed SFE.
Analyzing Bulk Flow Characteristics of Debris Flows Using Their High Frequency Seismic Signature
Authors: Zhang Zhen , Walter Fabian , McArdell Brian W. , de Haas Tjalling , Wenner Michaela , Chmiel Małgorzata , He Siming 
Published: December 2021

AbstractQuantifying debris‐flow characteristics remains a key challenge in natural hazard research. Recent studies suggest that seismic signals can reveal debris‐flow properties. However, the accuracy and applicability of theoretical models linking bulk flow properties to the seismic signature of a debris flow remain elusive. By extending a previously proposed model of random single‐particle impact forces to multi‐particle force chains acting on the channel bed, we describe the generation of high frequency seismic signals, and thereby estimate the bulk flow dynamics of six debris‐flow events at Illgraben, Switzerland. The theoretically predicted basal force fluctuations agree with in‐situ measurements at a basal force plate and seismic signals recorded adjacent to the channel. According to our model, both random single‐particle impacts and random impacts caused by multi‐particle force chains control basal force fluctuations. The relative contributions of single particles and of multi‐particle force chains may vary significantly for different events and different positions within events. The relative contribution of multi‐particle force chains is expected to be larger in the flow front, where particle concentrations are higher. The ratio between single‐particle and multi‐particle contributions appears to control the non‐linear relation between flow depth and the magnitude of the high frequency seismic signals. Our results suggest that fluctuating basal forces are strongly controlled by particle size and flow depth, and open new perspectives for the understanding of bulk flow characteristics, such as flow depth and weight, and of the high frequency seismic signals generated by debris flows.
The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism
Authors: Deng Yalan , Yang Yingming , Zhang Bin , Chen Hong , Lu Yangyu , Ren Shirui , Lei Lei , Hu Tao 
Published: December 2021

AbstractStreptococcus mutans (S. mutans) is generally regarded as a major contributor to dental caries because of its ability to synthesize extracellular polysaccharides (EPS) that aid in the formation of plaque biofilm. The VicRKX system of S. mutans plays an important role in biofilm formation. The aim of this study was to investigate the effects of vicK gene on specific characteristics of EPS in S. mutans biofilm. We constructed single-species biofilms formed by different mutants of vicK gene. Production and distribution of EPS were detected through atomic force microscopy, scanning electron microscopy and confocal laser scanning microscopy. Microcosmic structures of EPS were analyzed by gel permeation chromatography and gas chromatography-mass spectrometry. Cariogenicity of the vicK mutant was assessed in a specific pathogen-free rat model. Transcriptional levels of cariogenicity-associated genes were confirmed by quantitative real-time polymerase chain reaction. The results showed that deletion of vicK gene suppressed biofilm formation as well as EPS production, and EPS were synthesized mostly around the cells. Molecular weight and monosaccharide components underwent evident alterations. Biofilms formed in vivo were sparse and contributed a decreased degree of caries. Moreover, expressional levels of genes related to EPS synthesis were down-regulated, except for gtfB. Our report demonstrates that vicK gene enhances biofilm formation and subsequent caries development. And this may due to its regulations on EPS metabolism, like synthesis or microcosmic features of EPS. This study suggests that vicK gene and EPS can be considered as promising targets to modulate dental caries.
Targeting PI3K/Akt signal transduction for cancer therapy
Authors: He Yan , Sun Miao Miao , Zhang Guo Geng , Yang Jing , Chen Kui Sheng , Xu Wen Wen , Li Bin 
Published: December 2021

AbstractThe phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors. Examining the upstream and downstream nodes of this pathway could allow full elucidation of its function. Based on accumulating evidence, strategies targeting major components of the pathway might provide new insights for cancer drug discovery. Researchers have explored the use of some inhibitors targeting this pathway to block survival pathways. However, because oncogenic PI3K pathway activation occurs through various mechanisms, the clinical efficacies of these inhibitors are limited. Moreover, pathway activation is accompanied by the development of therapeutic resistance. Therefore, strategies involving pathway inhibitors and other cancer treatments in combination might solve the therapeutic dilemma. In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination therapies consisting of signaling inhibitors and conventional cancer therapies. The information presented herein suggests that cascading inhibitors of the PI3K/Akt signaling pathway, either alone or in combination with other therapies, are the most effective treatment strategy for cancer.
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity
Authors: Cao Huan , Duan Lixia , Zhang Yan , Cao Jun , Zhang Kun 
Published: December 2021

AbstractHydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) and influence cell signaling cascades and fate. In the past few decades, a plethora of pioneering studies have been implemented to explore the cell–hydrogel matrix interactions and figure out the underlying mechanisms, paving the way to the lab-to-clinic translation of hydrogel-based therapies. In this review, we first introduced the physicochemical properties of hydrogels and their fabrication approaches concisely. Subsequently, the comprehensive description and deep discussion were elucidated, wherein the influences of different hydrogels properties on cell behaviors and cellular signaling events were highlighted. These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganization, gene expression, and further cell biology modulation (e.g., spreading, migration, proliferation, lineage commitment, etc.). Based on them, current in vitro and in vivo hydrogel applications that mainly covered diseases models, various cell delivery protocols for tissue regeneration and disease therapy, smart drug carrier, bioimaging, biosensor, and conductive wearable/implantable biodevices, etc. were further summarized and discussed. More significantly, the clinical translation potential and trials of hydrogels were presented, accompanied with which the remaining challenges and future perspectives in this field were emphasized. Collectively, the comprehensive and deep insights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate cellular processes, which are available for providing significant indications for future hydrogel design and serving for a broad range of biomedical applications.
Face detection in untrained deep neural networks
Authors: Baek Seungdae , Song Min , Jang Jaeson , Kim Gwangsu , Paik Se-Bum 
Published: December 2021

AbstractFace-selective neurons are observed in the primate visual pathway and are considered as the basis of face detection in the brain. However, it has been debated as to whether this neuronal selectivity can arise innately or whether it requires training from visual experience. Here, using a hierarchical deep neural network model of the ventral visual stream, we suggest a mechanism in which face-selectivity arises in the complete absence of training. We found that units selective to faces emerge robustly in randomly initialized networks and that these units reproduce many characteristics observed in monkeys. This innate selectivity also enables the untrained network to perform face-detection tasks. Intriguingly, we observed that units selective to various non-face objects can also arise innately in untrained networks. Our results imply that the random feedforward connections in early, untrained deep neural networks may be sufficient for initializing primitive visual selectivity.