bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal healthcare at a Swiss university hospital chiropractic medicine outpatient clinic in 2019: a health services research study
Authors: Hofstetter Léonie , Häusler Melanie , Mühlemann Malin , Nyirö Luana , Mühlemann Daniel , Hincapié Cesar 
Published: September 2021

Abstract
Background
The Balgrist University Hospital in Zurich, Switzerland, is an academic hospital focused on musculoskeletal (MSK) disorders. An integrated chiropractic medicine clinic provides chiropractic care to a broad patient population. Our health services research study aims to advance understanding of chiropractic health care service for quality assurance and health care quality improvement.
Methods
An observational clinical cohort study at the Balgrist chiropractic medicine clinic in 2019 was performed. The records of all patients with initial visits or returning initial visits (> 3 months since last visit) and their subsequent visits from January 1, 2019 to December 31, 2019, were used to create the study dataset. Data collected included demographic characteristics, diagnoses, imaging data, conservative treatments, surgeries, and other clinical care data. Descriptive statistics were used to summarize data.
Results
1844 distinct patients (52% female, mean age 48 ± 17 years) were eligible and included in the study. 1742 patients had a single initial visit, 101 had 2 initial visits, and 1 patient had 3 initial visits during the study period. The most common main diagnoses were: low back pain (41%; 95% CI, 39–43%), neck pain (21%; 19–23%), and thoracic pain (8%; 7–9%). 29% had an acute (< 4 weeks) symptom duration, 10% subacute (4 to 12 weeks), and 52% chronic (> 12 weeks). Patients had a median number of 5 chiropractic visits during their episode of care, with a median care episode duration of 28 days. Only 49% (95% CI, 47–52%) of patient records had a clinical outcome that was extractable from routine clinical practice documentation retrievable from the hospital system.
Conclusion
Our health services research study provides an initial understanding of the patient characteristics and MSK clinical care delivered in a Swiss outpatient hospital setting and areas for clinical data quality assurance. Deeper insights into health care services and outcomes will help to facilitate a health quality improvement initiative by identifying clinical data and health care quality gaps, and establishing overall aims and targets for improvement.
Electron-Phonon Decoupling in Two Dimensions
Authors: McArdle George , Lerner Igor V. 
Published: September 2021

Abstract
In order to observe many-body localisation in electronic systems, decoupling from the lattice phonons is required, which is possible only in out-of-equilibrium systems. We show that such an electron-phonon decoupling may happen in suspended films and it manifests itself via a bistability in the electron temperature. By studying the electron-phonon cooling rate in disordered, suspended films with two-dimensional phonons, we derive the conditions needed for such a bistability, which can be observed experimentally through hysteretic jumps of several orders of magnitude in the nonlinear current-voltage characteristics. We demonstrate that such a regime is achievable in systems with an Arrhenius form of the equilibrium conductivity, while practically unreachable in materials with Mott or Efros-Shklovskii hopping.
Amyloid-beta peptide (25-35) triggers a reorganization of lipid membranes driven by temperature changes
Authors: Ivankov Oleksandr , Murugova Tatiana N. , Ermakova Elena V. , Kondela Tomáš , Badreeva Dina R. , Hrubovčák Pavol , Soloviov Dmitry , Tsarenko Alexey , Rogachev Andrey , Kuklin Alexander I. , Kučerka Norbert 
Published: September 2021

Abstract
The amyloid-beta peptide (Aβ) is considered a key factor in Alzheimer's disease (AD) ever since the discovery of the disease. The understanding of its damaging influence has however shifted recently from large fibrils observed in the inter-cellular environment to the small oligomers interacting with a cell membrane. We studied the effect of temperature on the latter interactions by evaluating the structural characteristics of zwitterionic phosphatidylcholine (PC) membranes with incorporated Aβ25-35 peptide. By means of small angle neutron scattering (SANS), we have observed for the first time a spontaneous reformation of extruded unilamellar vesicles (EULVs) to discoidal bicelle-like structures (BLSs) and small unilamellar vesicles (SULVs). These changes in the membrane self-organization happen during the thermodynamic phase transitions of lipids and only in the presence of the peptide. We interpret the dramatic changes in the membrane's overall shape with parallel changes in its thickness as the Aβ25-35 triggered membrane damage and a consequent reorganization of its structure. The suggested process is consistent with an action of separate peptides or a small number of peptide oligomers rather than the result of a large Aβ fibril.
Silver coated textile for versatile personal thermal management via multi-order reflections
Authors: Xie Xiaoyu , Liu Yang , Xu Zhao , Ge Dengteng , Yang Lili 
Published: September 2021

Abstract
Personal thermal management (PTM) is of paramount importance for reducing energy consumption and improving the thermal comfort of individuals. However, wearable textile via facile methods for indoor/outdoor PTM is still challenging. Here we present a novel simple yet effective method for versatile PTM via silver coated textile. Infrared transmittance of coated fabric is greatly enhanced by 150% due to the multi-order reflection of silver coating. Based on their IR radiative cooling, in indoor and outdoor, the skin surface temperature is lower by 1.1˚C and 0.9˚C than normal cloth, allowing the textile to be used in multiple environments. Moreover, the coated fabric is capable of active warming up under low voltage, which can be used in low-temperature conditions. These promising results exemplify the practicability of using silver coated textile as a personal thermal management cloth in versatile environments.
Title: Association of XRCC3, XRCC4, BAX and BCL-2 Polymorphisms with the Risk of Breast Cancer
Authors: Ozoran Emre , Trabulus Fadime Didem Can , Erhan Duygu , Batar Bahadir , Guven Mehmet 
Published: September 2021

Abstract
Background
Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified.
Aims
The aim of this study was to determine the association of XRCC3 Thr241Met (rs861539), XRCC4 G(-1394)T (rs6869366) DNA repair and BAX G(-248)A (rs4645878), BCL2 C(-938)A (rs2279115) apoptotic gene polymorphisms with breast cancer.
Materials and Methods
Genetic analysis was performed using peripheral blood samples. Gene polymorphisms were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. 175 patients and 158 healthy controls were enrolled in the study.
Results
Breast cancer risk was 5.43 times more in individuals with AA genotype of Bax G(-248)A (rs4645878) (p = 0.002). The risk of metastasis was 11 times with this genotype. It was associated with 6 times more risk of having a tumor larger than 2 cm. The risk of breast cancer was 2.77 times more in individuals carrying the Met/Met genotype of XRCC3 Thr241Met (rs861539) (p = 0.009). The risk of having advanced clinical stage (stage III + IV) with the Met/Met genotype was 4 times more increased. No relationship with breast cancer was found with XRCC4 G(-1394)T (rs6869366) and BCL2 C(− 938)A(rs2279115) gene polymorphisms.
Conclusion
Multi-center trials using subjects with genetic variations are needed to establish the relationship between breast cancer and single gene polymorphism.
The COVID-19 Hospitalization Metric in the Pre- and Post-vaccination Eras as a Measure of Pandemic Severity: A Retrospective, Nationwide Cohort Study
Authors: Fillmore Nathanael , La Jennifer , Zheng Chunlei , Doron Shira , Do Nhan , Monach Paul , Branch-Elliman Westyn 
Published: September 2021

Abstract

Importance: Since the early days of the pandemic, COVID-19 hospitalizations have been used as a measure of pandemic severity. However, case definitions do not include assessments of disease severity, which may be impacted by prior vaccination.Objective: To measure how the severity of respiratory disease changed among inpatients with documented SARS-CoV-2 infection and to measure the impact of vaccination status on these trends, in order to evaluate the accuracy of the metric of “hospitalization plus a positive SARS-CoV-2 test” for tracking pandemic severity.Design: Retrospective cohort of inpatients with laboratory-confirmed SARS-CoV-2. All data were obtained from electronic health records.Setting: Multi-center, nationwide study conducted in the healthcare system of the US Department of Veterans Affairs (VA) from March 1, 2020, through June 30, 2021.Participants: All VA patients admitted to a VA hospital with a laboratory-confirmed SARS-CoV-2 infection within the 14-days prior to admission or during the hospital admission.Main Outcome: Moderate-to-severe COVID-19 disease, defined by use of any supplemental oxygen or documented SpO2 <94%, during an inpatient hospitalization between one day before and two weeks after a positive SARS-CoV-2 test.Exposure: SARS-CoV-2 vaccination status at the time of hospitalization. Patients were regarded as fully vaccinated starting 14 days after receiving the second of a 2-dose regimen or 14 days after receipt of a single-dose vaccine.Results: Among 47,742 admissions in 38,508 unique patients with laboratory-confirmed SARS-CoV-2, N=28,731 met the criteria for moderate-to-severe COVID-19. The proportion with moderate-to-severe disease prior to widespread vaccine availability was 64.0% (95% CI, 63.1-64.9%) versus 52.0% in the later period (95% CI, 50.9-53.2%), p-value for non-constant effect, <0.001. Disease severity in the vaccine era among hospitalized patients was lower among both unvaccinated (55.0%, 95% CI, 53.7-56.4%) and vaccinated patients (42.6%, 95% CI, 40.6-44.8%).Conclusions and Relevance: The proportion of hospitalizations that are due to severe COVID-19 has changed with vaccine availability, thus, increasing proportions of mild and asymptomatic cases are included in hospitalization reporting metrics. The addition of simple measures of disease severity to the case definition of a SARS-CoV-2 hospitalization is a straightforward and objective change that should improve the value of the metric for tracking SARS-CoV-2 disease burden.
PARÂMETROS PARA ESTABELECIMENTO DE POLÍTICA DE GESTÃO DE ESTOQUE EM HOSPITAIS PÚBLICOS UNIVERSITÁRIOS
Authors: Lopes de Souza Claudia , Gerardin Poirot Land Marcelo 
Published: September 2021

O objetivo deste trabalho foi estabelecer parâmetros para política de compras eficiente e adequada à realidade de uma organização pública de saúde. Para tal, foram explorados os principais tópicos inerentes ao bom planejamento de estoque e suas peculiaridades ao adaptá-los ao sistema público brasileiro. Demonstra-se que o custo total da operação vai variar consideravelmente, tanto com a variação do tempo de resposta quanto com o intervalo entre as revisões de estoque. Ao menos para itens de alto custo, assumir revisões frequentes e menores tempos de resposta é essencial para economia hospitalar. A sazonalidade e variação de demanda, também têm seu impacto quantificado no artigo. Ao abordar nível de serviço, lida com o desafio de diminuir a super estocagem sem incorrer em falta de insumos. A estratificação é artifício apropriado para minimizar custos enquanto que a definição de limites orçamentários possibilita racionalizar pedidos. Ajustar o planejamento de estoque à realidade da gestão pública é um desafio e a simulação de cenários permite antever gargalos e deficiências.
Palavras-chave: logística hospitalar, gestão estoque, planejamento de compras.
Methane production from food waste using a feedback control strategy in a sequencing batch reactor
Authors: Jiménez-Ocampo U. E. , Vargas A. , Moreno-Andrade I. 
Published: September 2021

AbstractThe performance of a feedback control strategy in the operation of a sequencing batch reactor was evaluated. This strategy uses the online biogas flow measurements to define the duration of the reaction phase of each operating cycle, thereby increasing the energy production of the system and maximizing the methane production rate. The reaction phase is ended when the biogas flow rate reaches a sustained value significantly lower value than the maximum flow rate achieved, as a consequence of the depletion of the soluble chemical oxygen demand. The implementation of the depletion-time control was successful and reached a maximum methane production rate of 1.22 L CH4/d, showing an average productivity of 0.73 ± 0.3 L CH4/d. The reaction phase varied from 1.2 to 6 days with hydraulic retention times from 6 to 30 days. The use of this feedback control strategy increased the methane production and the energy production in 80% of the evaluated cycles (from 10.4 to 43.8%) compared to the operation of conventional AD without a control strategy. Furthermore, the strategy is easy to implement since it does not require complex calculations and uses a readily available biogas flow rate sensor.
INTERSETORIALIDADE NA PROMOÇÃO DA SAÚDE DA CRIANÇA E DO ADOLESCENTE: UMA EXPERIÊNCIA DA INTEGRAÇÃO ENSINO-SERVIÇO
Authors: De Azevedo Machado Flávia Christiane , Dantas de Oliveira Nayara Priscila , Maia Morais Gabriel , Peres dos Santos Gabriel , Pelogio de Macedo Yasmin 
Published: September 2021

Introdução: Para instituir a intersetorialidade como prática cotidiana deve-se viabilizar uma formação profissional coerente. Neste sentido, experiências ensino-serviço são importantes meios para esta formação. Objetivo: Relatar a experiência das ações voltadas a adolescentes e crianças desenvolvidas em equipamentos sociais adscritos a uma Unidade Saúde da Família de Natal-RN em 2018.2 no contexto da disciplina Saúde e Cidadania. Metodologia: A partir do conhecimento geral do território e compreensão de sua dinâmica, sob o referencial da problematização, foram desenvolvidos planos operativos, articulando lideranças locais e comunidade, para contribuir com o desenvolvimento local. Desta forma, foram realizadas três intervenções: estações temáticas para abordar programas do governo de acesso à educação superior e técnica, carreira militar; Infecção Sexualmente Transmissível, hábitos alimentares saudáveis e iniquidades utilizando dinâmica interativa (escola estadual); gincana com as crianças e uma palestra com os pais sobre os desafios para a educação dos filhos (Centro de convivência) e teatro de fantoches sobre higiene pessoal; musicalização com as crianças; dinâmica com massinhas e pintura; instrução sobre lavagem das mãos e escovação dos dentes; momento literário (Centro Municipal de Educação Infantil). Resultados: As intervenções tiveram um caráter intersetorial e obtiveram um balanço positivo tanto pelo público-alvo, como pelos membros do grupo tutorial. As atividades realizadas propiciaram produtos de extensão (paródia; jogo; dinâmica) que viabilizaram trabalhar habilidades cognitivas, artísticas e relacionais do grupo, favorecendo a transformação do grupo em uma equipe. O grupo tutorial buscou estimular os equipamentos sociais a atuarem em conjunto, buscando a prática vivencial da intersetorialidade. Além disso, buscou difundir informações sobre determinantes sociais da educação e alimentação, objetivando maior empoderamento da comunidade. Conclusões: Os produtos gerados na experiência podem ser utilizados em outros contextos conferindo uma maior amplitude de alcance deste relato como um referencial de ações a serem desenvolvidas.
The Role of Celecoxib as a Potential Inhibitor in the Treatment of
Inflammatory Diseases - A Review
Authors: Cruz Josiane Viana , Rosa Joaquín María Campos , Kimani Njogu Mark , Giuliatti Silvana , dos Santos Cleydson Breno Rodrigues 
Published: September 2021

Abstract:
This article aims at reviewing celecoxib as a potential inhibitor in the treatment
of inflammatory diseases. The enzyme cyclooxygenase (COX) predominantly has
two isoforms called cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2). The
former plays a constitutive role related to homeostatic effects in renal and platelets, while
the latter is mainly responsible for the induction of inflammatory effects. Since COX-2
plays an important role in the pathogenesis of inflammatory diseases, it has been signaled
as a target for the planning of anti-inflammatory intermediates. Many inhibitors developed
and planned for COX-2 inhibition have presented side effects to humans, mainly in
the gastrointestinal and/or cardiovascular tract. Therefore, it is necessary to design new
potential COX-2 inhibitors, which are relatively safe and have no side effects. In this
sense, celecoxib is the only potent, selective COX-2 inhibitor that is still commercially
available (within the “coxib” family). Thus, celecoxib became a commercial prototype inhibitor
for the development of anti-inflammatory agents for the COX-2 enzyme. This review
provides inhibition highlights that should provide a structural basis for the design of
promising new non-steroidal anti-inflammatory drugs (NSAIDs), which act as COX-2 inhibitors
with lesser side effects on the human body.
Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic
Relationship
Authors: Rezaee Mohammad Ahangarzadeh , Nouri Roghayeh , Hasani Alka , Shirazi Kourosh Masnadi , Alivand Mohammad Reza , Sepehri Bita , Sotoodeh Simin , Hemmati Fatemeh 
Published: September 2021

Abstract:
Colorectal cancer (CRC) is one of the deadliest cancers in the world. Specific strains of intestinal Escherichia coli (E. coli) may influence the initiation and development of CRC by exploiting virulence factors and inflammatory pathways. Mucosa-associated E. coli strains are more prevalent in CRC biopsies in comparison to healthy controls. Moreover, these strains can survive and replicate within macrophages and induce a pro-inflammatory response. Chronic exposure to inflammatory mediators can lead to increased cell proliferation and cancer. Production of colobactin toxin by the majority of mucosa-associated E. coli isolated from CRC patients is another notable finding. Colibactin-producing E. coli strains, in particular, induce double-strand DNA breaks, stop the cell cycle, involve in chromosomal rearrangements of mammalian cells and are implicated in carcinogenic effects in animal models. Moreover, some enteropathogenic E. coli (EPEC) strains are able to survive and replicate in colon cells as chronic intracellular pathogens and may promote susceptibility to CRC by downregulation of DNA Mismatch Repair (MMR) proteins. In this review, we discuss current evidence and focus on the mechanisms by which E. coli can influence the development of CRC.
Recent Advancement in the One-pot Synthesis of the Tri-substituted
Methanes (TRSMs) and their Biological Applications
Authors: Verma Monika , Thakur Ajay , Sharma Renu , Bharti Ruchi 
Published: September 2021

:
The history of tri-substituted methanes (TRSMs) in chemical industries is much older. Tri-substituted methanes were previously used as dyes in the chemical industries. Still, there is a significant surge in researchers' interest in them due to their wide range of bioactivities. Tri-substituted methane derivatives show a wide range of biological activities like anti-tumor, antimicrobial, antibiofilm, antioxidant, anti-inflammatory, anti-arthritic activities. Due to the wide range of medicinal applications shown by tri-substituted methanes, most of the methodologies reported in the literature for the synthesis of TRSMs are focused on the one-pot method. This review explored the recently reported one-pot processes for synthesizing tri-substituted methanes and their various medicinal applications. Based on the substitution attached to the -CH carbon, this review categorizes them into two major classes: (I) symmetrical and (II) unsymmetrical trisubstituted methanes. In addition, this review gives an insight into the growing opportunities for the construction of trisubstituted scaffolds via one-pot methodologies. To the best of our knowledge, no one has yet reported a review on the one-pot synthesis of TRSMs. Therefore, here we present a brief literature review of the synthesis of both symmetrical and unsymmetrical TRSMs covering various one-pot methodologies along with their medicinal applications.
Ag-catalyzed Multicomponent Synthesis of Heterocyclic Compounds: A
Review
Authors: Mamaghani Manouchehr , Nia Roghayeh Hossein , Tavakoli Fatemeh 
Published: September 2021

Abstract:
The investigation of the procedures for the multi-component synthesis of heterocycles has attracted the interest of organic and medicinal chemists. The use of heterogeneous catalysts, especially transition metal catalysts in organic synthesis, can provide a new, improved alternative to traditional methods in modern synthetic chemistry. The main focus is on the utilization of silver as a catalyst for the multi-component synthesis of heterocyclic compounds. The present review describes some important reported studies for the period of 2010 to 2020.

Conclusion:
The present review addresses some of the important reported studies on multi-component synthesis of heterocycles in the period of 2010-2020. These approaches were performed under classical and nonclassical conditions, using Ag salts, Ag NPs, Ag on the support, Ag as co-catalysts with other transition metals, ionic liquids, acidic or basic materials. Most of the reported reactions were performed under solvent-free conditions or in green solvents and the utilized catalysts were mostly recyclable. The main aim of the present review is to provide the organic chemists with the most appropriate procedures in the multi-component synthesis of desired heterocycles using silver catalysts.
Recent Advances in the Green Synthesis of Heterocycles: From Building
Blocks to Biologically Active Compounds
Authors: Schäfer Christian , Cho Hyejin , Vlocskó Bernadett , Xie Guoshu , Török Béla 
Published: September 2021

:
Recent advances in the environmentally benign synthesis of common heterocycles are described. This account features three main parts; the preparation of non-aromatic heterocycles, one-ring aromatic heterocycles and their condensed analogs. Due to the great variety of and high interest in these compounds, this work focuses on providing representative examples of the preparation of the target compounds.
Inactivation of PDH can Reduce Anaplastic Thyroid Cancer Cells’ Sensitivity to Artemisinin
Authors: Li Yitian 
Published: September 2021

Background:
Anaplastic Thyroid Cancer (ATC) is a rare subtype of thyroid tumors with a high mortality
rate. Targeted therapies against ATC are ineffective and mostly transient. Artemisinin has shown excellent anti-tumor
activity in several cancers, but its effects on ATC are still unknown.

Objective:
To evaluate the effects of artemisinin on ATC cells and assess the mechanism underlying drug resistance.

Methods:
The viability and proliferation rates of the artemisinin-treated CAL-62 and BHT-101 cells were analyzed by
MTT and EdU incorporation assays. The protein expression levels were determined by Tandem Mass Tag (TMT)
labeling quantitative proteomics and western blotting.

Results:
Artemisinin treatment significantly decreased the expression levels of COX2 and COX7A2 and increased that
of COX14, YEM1l1, ALAS1, and OAT after 48h. In addition, FTL was upregulated in the CAL-62 cells and downregulated
in BHT-101 cells. The CAL-62 cells showed transient and reversible resistance to artemisinin, which was
correlated to time-dependent changes in HIF1α, PDK1, and PDHA levels.

Conclusion:
Artemisinin targets the mitochondrial respiratory chain proteins in ATC cells. CAL-62 cells show transient
resistance to artemisinin via PDH downregulation, indicating that PDH activation may enhance the cytotoxic
effects of artemisinin on ATC cells