bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling the corporate entrepreneurship construct: conceptualizing through co-words
Authors: Castriotta Manuel , Loi Michela , Marku Elona , Moi Ludovica 
Published: February 2021

AbstractThis study defines the conceptual structure of corporate entrepreneurship (CE) by looking at the terms scholars have used over the last 26 years of research. With the use of a co-word analysis, five distinctive dimensions of CE and the evolution of related key terms are identified: sustained regeneration, competitive advantage, external entrepreneurship, organizational rejuvenation, and domain redefinition. Over time scholars’ attention has shifted from strategy to entrepreneurship by highlighting the relevance of the terms ‘intrapreneurship’ and ‘entrepreneurial orientation’. Surprisingly, concepts related to strategic entrepreneurship and strategic renewal are less relevant than expected. Besides laying the ground for a shared conceptualization of CE, this study highlights how bibliomeitrics can contribute to decreasing conceptual ambiguity in emergent research fields, such as entrepreneurship. Implications for managers on how to strategically create and develop CE within different organizational settings are also discussed.
Precious Metal Distributions Between Copper Matte and Slag at High $$ P_{{{\text{SO}}_{ 2} }} $$ in WEEE Reprocessing
Authors: Chen Min , Avarmaa Katri , Klemettinen Lassi , O’Brien Hugh , Shi Junjie , Taskinen Pekka , Lindberg Daniel , Jokilaakso Ari 
Published: February 2021

Abstract
The distributions of precious metals (gold, silver, platinum, and palladium) between copper matte and silica-saturated FeO
x
-SiO2/FeO
x
-SiO2-Al2O3/FeO
x
-SiO2-Al2O3-CaO slags were investigated at 1300 °C and

$$ P_{{{\text{SO}}_{ 2} }} $$

P

SO
2

= 0.5 atm. The experiments were carried out in silica crucibles under flowing CO-CO2-SO2-Ar gas atmosphere. The concentrations of precious metals in matte and slag were analyzed by Electron Probe X-ray Microanalysis and Laser Ablation-High-Resolution Inductively Coupled Plasma-Mass Spectrometry, respectively. The precious metal concentrations in matte and slag, as well as the distribution coefficients of precious metals between matte and slag, were displayed as a function of matte grade. The present results obtained at

$$ P_{{{\text{SO}}_{ 2} }} $$

P

SO
2

of 0.5 atm were compared with previous results at

$$ P_{{{\text{SO}}_{ 2} }} $$

P

SO
2

of 0.1 atm for revealing the effects of

$$ P_{{{\text{SO}}_{ 2} }} $$

P

SO
2

and selected slag modifiers (CaO and Al2O3) on precious metal distributions at copper matte smelting conditions. The present results also contribute experimental thermodynamic data of precious metal distributions in pyrometallurgical reprocessing of electronic waste via copper smelting processes.
Single-Cell RNA Sequencing of the Adult Mammalian Heart—State-of-the-Art and Future Perspectives
Authors: Gladka Monika M. 
Published: February 2021

Abstract
Purpose of the Review
Cardiovascular disease remains the leading cause of death worldwide, resulting in cardiac dysfunction and, subsequently, heart failure (HF). Single-cell RNA sequencing (scRNA-seq) is a rapidly developing tool for studying the transcriptional heterogeneity in both healthy and diseased hearts. Wide applications of techniques like scRNA-seq could significantly contribute to uncovering the molecular mechanisms involved in the onset and progression to HF and contribute to the development of new, improved therapies. This review discusses several studies that successfully applied scRNA-seq to the mouse and human heart using various methods of tissue processing and downstream analysis.

Recent Findings
The application of scRNA-seq in the cardiovascular field is continuously expanding, providing new detailed insights into cardiac pathophysiology.

Summary
Increased understanding of cardiac pathophysiology on the single-cell level will contribute to the development of novel, more effective therapeutic strategies. Here, we summarise the possible application of scRNA-seq to the adult mammalian heart.
Not all homeowners are alike: a segmentation model based on a quantitative analysis of Dutch adopters of residential photovoltaics
Authors: Broers Wendy , Vasseur Veronique , Kemp René , Abujidi Nurhan , Vroon Zeger 
Published: February 2021

AbstractThe implementation of residential photovoltaics must increase more rapidly to combat climate change and its impacts. This challenge is addressed in this study by introducing a segmentation model in order to develop a theoretical and empirical foundation for understanding the heterogeneity of potential adopters. Data were collected by means of a survey among Dutch adopters (n = 1395) and the data is analysed with statistical descriptive analyses and nonparametric tests. The five segmentation groups are divided by the homeowners’ educational background or profession (technical, financial-economic or other) and level of environmental concern. The results demonstrate that the groups are substantial in size and that there are significant differences between these groups on personal characteristics such as homeowners’ level of environmental concern and the level of influence of their social network on their decision to adopt. In addition, significant differences are found between the groups on the perceived characteristics of the residential photovoltaics such as perceived complexity and aesthetics, and the amount of previous practice with other energy measures in their home. Accordingly, these insights can be used by policymakers and the public and private sectors to promote residential photovoltaics more effectively by targeting the segmentation groups more adequately. The different groups will be drawn to different aspects and therefore, a broader pallet of benefits must be presented; a mix of different communication channels must be used; objective and non-technical assistance in the decision-making must be offered; and different kind of products must be provided.
Checkpoint inhibitor induced hepatitis and the relation with liver metastasis and outcome in advanced melanoma patients
Authors: Biewenga Maaike , van der Kooij Monique K. , Wouters Michel W. J. M. , Aarts Maureen J. B. , van den Berkmortel Franchette W. P. J. , de Groot Jan Willem B. , Boers-Sonderen Marye J. , Hospers Geke A. P. , Piersma Djura , van Rijn Rozemarijn S. , Suijkerbuijk Karijn P. M. , ten Tije Albert J. , van der Veldt Astrid A. M. , Vreugdenhil Gerard , Haanen John B. A. G. , van der Eertwegh Alfons J. M. , van Hoek Bart , Kapiteijn Ellen 
Published: February 2021

Abstract
Background
Checkpoint inhibitor-induced hepatitis is an immune-related adverse event of programmed cell death protein 1 (PD-1) inhibition, cytotoxic T-lymphocyte associated 4 (CTLA-4) inhibition or the combination of both. Aim of this study was to assess whether checkpoint inhibitor-induced hepatitis is related to liver metastasis and outcome in a real-world nationwide cohort.

Methods
Data from the prospective nationwide Dutch Melanoma Treatment Registry (DMTR) was used to analyze incidence, risk factors of checkpoint inhibitor-induced grade 3–4 hepatitis and outcome.

Results
2561 advanced cutaneous melanoma patients received 3111 treatments with checkpoint inhibitors between May 2012 and January 2019. Severe hepatitis occurred in 30/1620 (1.8%) patients treated with PD-1 inhibitors, in 29/1105 (2.6%) patients treated with ipilimumab and in 80/386 (20.7%) patients treated with combination therapy. Patients with hepatitis had a similar prevalence of liver metastasis compared to patients without hepatitis (32% vs. 27%; p = 0.58 for PD-1 inhibitors; 42% vs. 29%; p = 0.16 for ipilimumab; 38% vs. 43%; p = 0.50 for combination therapy). There was no difference in median progression free and overall survival between patients with and without hepatitis (6.0 months vs. 5.4 months progression-free survival; p = 0.61; 17.0 vs. 16.2 months overall survival; p = 0.44).

Conclusion
Incidence of hepatitis in a real-world cohort is 1.8% for PD-1 inhibitor, 2.6% for ipilimumab and 20.7% for combination therapy. Checkpoint inhibitor-induced hepatitis had no relation with liver metastasis and had no negative effect on the outcome.
On Finite Energy Solutions of 4-harmonic and ES-4-harmonic Maps
Authors: Branding Volker 
Published: February 2021

Abstract4-harmonic and ES-4-harmonic maps are two generalizations of the well-studied harmonic map equation which are both given by a nonlinear elliptic partial differential equation of order eight. Due to the large number of derivatives it is very difficult to find any difference in the qualitative behavior of these two variational problems. In this article we prove that finite energy solutions of both 4-harmonic and ES-4-harmonic maps from Euclidean space must be trivial. However, the energy that we require to be finite is different for 4-harmonic and ES-4-harmonic maps pointing out a first difference between these two variational problems.
Translational Science for Climate Services: Mapping and Understanding Users’ Climate Service Needs in CSSP China
Authors: Opitz-Stapleton Sarah , Street Roger , Ye Qian , Han Jiarui , Hewitt Chris D. 
Published: February 2021

AbstractThe Climate Science for Service Partnership China (CSSP China) is a joint program between China and the United Kingdom to build the basis for climate services to support the weather and climate resilient economic development and welfare in China. Work Package 5 (WP5) provides the translational science on identification of: different users and providers, and their mandates; factors contributing to communication gaps and capacities between various users and providers; and mechanisms to work through such issues to develop and/or evolve a range of climate services. Key findings to emerge include that users from different sectors have varying capacities, requirements, and needs for information in their decision contexts, with a current strong preference for weather information. Separating climate and weather services when engaging users is often not constructive. Furthermore, there is a need to move to a service delivery model that is more user-driven and science informed; having sound climate science is not enough to develop services that are credible, salient, reliable, or timely for diverse user groups. Greater investment in building the capacity of the research community supporting and providing climate services to conduct translational sciences and develop regular user engagement processes is much needed. Such a move would help support the China Meteorological Administration’s (CMA) ongoing efforts to improve climate services. It would also assist in potentially linking a broader group of “super” users who currently act as providers and purveyors of climate services because they find the existing offerings are not relevant to their needs or cannot access CMA’s services.
Von Gallup zu Big Data. Rekonstruktion und Neujustierung der Debatte über Meinungsforschung und Demokratie
Authors: Dormal Michel 
Published: February 2021

ZusammenfassungAusgangspunkt des Beitrags ist die Feststellung, dass im Zuge aktueller Debatten über Big Data, wie sie etwa der Skandal rund um Cambridge Analytica und Facebook provozierte, eine Reihe von weiterhin unbeantworteten Fragen wieder auftauchen, die bereits in der älteren Kontroverse rund um das Verhältnis von Demoskopie und Demokratie verhandelt wurden. Auf diese Kontroverse wird daher entlang der vier Punkte Aufklärung, Gleichheit, Teilhabe und gutes Regieren ein neuer Blick geworfen. Im Ergebnis wird ein demoskopischer und ein konfigurativer Modus der Verdopplung von Gesellschaft idealtypisch unterschieden. Beide haben an einer modernen Entwicklung teil, in der von Einheit auf Pluralität umgestellt wird. Im Sinne eines demokratietheoretischen Pluralismus wird versucht, Minimalbedingungen einer komplexen Balance zu benennen und mögliche Herausforderungen derselben durch neue Technologien herauszuarbeiten. Diese zugleich offene und auf einer gewissen Abstraktionshöhe angesiedelte Perspektive vermag nicht nur, die Kontinuität in der Diskontinuität und die Herausforderungen durch Big-Data-gestützte Formen der Demoskopie neu zu beschreiben, sondern eignet sich auch als Heuristik für konkrete Problemfelder.
Review and Development of Electric Motor Systems and Electric Powertrains for New Energy Vehicles
Authors: Cai William , Wu Xiaogang , Zhou Minghao , Liang Yafei , Wang Yujin 
Published: February 2021

AbstractThis paper presents a review on the recent research and technical progress of electric motor systems and electric powertrains for new energy vehicles. Through the analysis and comparison of direct current motor, induction motor, and synchronous motor, it is found that permanent magnet synchronous motor has better overall performance; by comparison with converters with Si-based IGBTs, it is found converters with SiC MOSFETs show significantly higher efficiency and increase driving mileage per charge. In addition, the pros and cons of different control strategies and algorithms are demonstrated. Next, by comparing series, parallel, and power split hybrid powertrains, the series–parallel compound hybrid powertrains are found to provide better fuel economy. Different electric powertrains, hybrid powertrains, and range-extended electric systems are also detailed, and their advantages and disadvantages are described. Finally, the technology roadmap over the next 15 years is proposed regarding traction motor, power electronic converter and electric powertrain as well as the key materials and components at each time frame.
Weight loss monitoring reduces the occurrence of neonatal hypernatremic dehydration in breastfeeding neonates
Authors: Zia Muhammad TK. , Golombek Sergio , Nitkowski-Keever Sabrina , Paudel Umesh 
Published: February 2021

Background:
Excessive weight loss enhances the incidence of neonatal hypernatremic dehydration (NHD). We compared the effect of a new breastfeeding policy against an old breastfeeding policy on neonatal weight change and the incidence of NHD.

Methods:
This was a QA project between two sets of breastfeeding (BF) protocols for exclusively BF newborns. Under our old BF policy, a number of neonates had a significant loss of weight after birth and were admitted to the NICU due to NHD. We implemented a new BF policy that was used when a newborn loses>5% of previously recorded weight within a 24-h interval. Two groups were compared: the preintervention group (old BF policy) and postintervention group (new BF policy). Additionally, characteristics of newborns admitted to NICU were separately compared with the subgroup of pre- and post intervention dehydration groups.

Results:
Preintervention = 1320 and postintervention = 1450. Neonates with weight loss of > 5% within the first 24-h time interval were higher in the postintervention group (19.7%) as compared to the pre-intervention group (10.2%) (P < .05). However, the number of infants diagnosed to have NHD was lower in the postintervention group (0.68%) than in the preintervention group (1.66%), (P < .03). Neonatal characteristics were comparable between subgroups of dehydration.

Conclusion:
An intervention at ≥ 5% neonatal weight loss markedly reduces the incidence of NHD- associated NICU admissions.
Guidelines for Patient-Centered Opioid Prescribing and Optimal FDA-Compliant Disposal of Excess Pills after Inpatient Operation: Prospective Clinical Trial
Authors: Porter Eleah D. , Bessen Sarah Y. , Molloy Ilda B. , Kelly Julia L. , Ramkumar Niveditta , Phillips Joseph D. , Loehrer Andrew P. , Wilson Matthew Z. , Hasson Rian M. , Ivatury Srinivas J. , Henkin Jessica R. , Barth Richard J. 
Published: February 2021

BACKGROUND:
To optimize responsible opioid prescribing after inpatient operation, we implemented a clinical trial with the following objectives: prospectively validate patient-centered opioid prescription guidelines and increase the FDA-compliant disposal rate of leftover opioid pills to higher than currently reported rates of 20% to 30%.

STUDY DESIGN:
We prospectively enrolled 229 patients admitted for 48 hours or longer after elective general, colorectal, urologic, gynecologic, or thoracic operation. At discharge, patients received a prescription for both nonopioid analgesics and opioids based on their opioid usage the day before discharge: if 0 oral morphine milligram equivalents (MME) were used, then five 5-mg oxycodone pill-equivalents were prescribed; if 1 to 29 MME were used, then fifteen 5-mg oxycodone pill-equivalents were prescribed; if 30 or more MME were used, then thirty 5-mg oxycodone pill-equivalents were prescribed. We considered patients' opioid pain medication needs to be satisfied if no opioid refills were obtained. To improve FDA-compliant disposal of leftover pills, we implemented patient education, convenient drop-box, reminder phone call, and questionnaire.

RESULTS:
Our opioid guideline satisfied 93% (213 of 229) of patients. Satisfaction was significantly higher in lower opioid usage groups (p = 0.001): 99% (99 of 100) in the 0 MME group, 90% (91 of 101) in the 1 to 29 MME group, and 82% (23 of 28) in the 30 or more MME group. Overall, 95% (217 of 229) of patients used nonopioid analgesics. Sixty percent (138 of 229) had leftover pills; 83% (114 of 138) disposed of them using an FDA-compliant method and 51% (58 of 114) used the convenient drop-box. Of 2,604 prescribed pills, only 187 (7%) were kept by patients.

CONCLUSIONS:
This clinical trial prospectively validated a patient-centered opioid discharge prescription guideline that satisfied 93% of patients. FDA-compliant disposal of excess pills was achieved in 83% of patients with easily actionable interventions.
ICD-11 Paraphilic Disorders: A South African Analysis of Its Utility in the Medico-Legal Context
Authors: Artz Lillian , Swanepoel Magdaleen , Nagdee Mohammed , Combrinck Helene , Kaliski Sean , Stein Dan J. , Butterworth J. 
Published: February 2021

ABSTRACTBackgroundIn an effort to improve the clinical utility of the ICD-10, the WHO Working Group on the Classification of Sexual Disorders and Sexual Health recommended a new classification of Paraphilic Disorders in the ICD-11 to replace the ICD-10 section on Disorders of Sexual Preference. The proposed classification may have different implications for different countries. AIM: To examine South African national laws and policies, within which Paraphilic Disorders are encountered, and to assess the implications of the new classification.MethodA South African working group - representing experts within the disciplines of criminal law, psychiatry, psychology, public health, and criminology - reviewed: (i) national laws affected by reclassification, (ii) current practices in the psycho-legal assessment of sexual offenders, (iii) the implications of the reclassification for assessment and decision-making in forensic practice and other health settings, (iv) specific implications of the reclassification for diagnosis, and (v) implications of the reclassification as it relates to the demographic and sociocultural context of South Africa.OutcomesAs a rule, South African courts do not accept the existence of a Paraphilic Disorder on its own to be sufficient grounds to absolve any defendant from criminal responsibility though defence. Nevertheless, a diagnosis such as coercive sexual sadism disorder runs the risk of medicalization of criminal behavior with inappropriate use to mitigate sentences.Clinical ImplicationsThe ICD-11 approach is clinically useful in emphasizing that a broad range of sexual behavior fall under the rubric of healthy sexual behavior, but also that compulsive sexual behavior can be pathological.Strengths and LimitationsThis analysis was conducted by an interdisciplinary expert group, aligning international forensic mental health and national legal constructs in a low-middle income country (LMIC). The analysis is limited by its reliance on expert opinion rather than empirical data.CONCLUSIONSIt is recommended that the ICD-11 includes a cautionary statement for forensic use, highlighting the fact that the mere inclusion of a diagnosis in the ICD-11 does not necessarily have forensic relevance.
Access to Endovascular Thrombectomy for Stroke in Rural Versus Urban Regions
Authors: Yan Yi , Hu Kai , Alcock Susan , Ghrooda Esseddeeg , Trivedi Anurag , McEachern James , Kaderali Zul , Shankar Jai 
Published: February 2021

ABSTRACT:Purpose:Endovascular thrombectomy (EVT) significantly improves outcomes for acute ischemic stroke patients with large vessel occlusion (LVO) who present in a time sensitive manner. Prolonged EVT access times may reduce benefits for eligible patients. We evaluated the efficiency of EVT services including EVT rates, onset-to-CTA time and onset-to-groin puncture time in our province.Materials and methods:Three areas were defined: zone I- urban region, zone II-areas within 1 h drive distance from the Comprehensive Stroke Center (CSC); and zone III-areas more than 1hr drive distance from the CSC. In this retrospective cohort study, EVT rate, onset-to-groin puncture time and onset-to-CTA time were compared among the three groups using Krustal–Wallis and Wilcoxon tests.Results:The EVT rate per 100,000 inhabitants for urban zone I was 8.6 as compared to 5.1 in zone II, and 7.5 in zone III. Compared to zone I (114 min; 95% CI (96, 132); n = 128), mean onset-to-CTA time was 19 min longer in zone II (133 min; 95% CI (77, 189); n = 23; p = 0.0459) and 103 min longer in zone III (217 min, 95% CI (162, 272); n = 44; p < 0.0001). Compared to zone I (209 min, 95% CI (181, 238)), mean onset-to-groin puncture time was 22 min longer in zone II (231 min, 95% CI (174, 288); p = 0.046) but 163 min longer in zone III (372 min, 95% CI (312, 432); p < 0.0001).Conclusion:EVT access in rural areas is considerably reduced with significantly longer onset-to-groin puncture times and onset-to-CTA times when compared to our urban area. This may help in modifying the patient transfer policy for EVT referral.
Converging Luminosity in Column‐Sprite Filaments
Authors: Gomez Kuri Z. , Soula S. , Neubert T. , Mlynarczyk J. , Köhn C. 
Published: February 2021

AbstractSprites are electrical discharges in the mesosphere powered by the quasi‐electrostatic field following a cloud‐to‐ground lightning stroke. They are luminous structures with tendrils formed by a space charge wave with high electric fields that ionizes the atmosphere, excites optical emissions and leaves a trail of enhanced densities of electrons, and negative and positive ions. The duration of the luminous streamers in sprites is usually ∼1–10 ms. In this study, we present observations of sprite streamer filaments where the upper and lower ends continue to glow for more than 80 ms while the two ends slowly converge and fade. Simultaneous magnetic observations suggest that the field in the mesosphere is maintained at a high value by the long‐lasting continuing current of the causative stroke. We propose that the observation is a signature of currents in the filaments fed by electrons detached from negative ions at the lower origin.