bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimated Economic Burden of Cancer Associated with Suboptimal Diet in the United States
Authors: Khushalani Jaya Shankar , Cudhea Frederick , Ekwueme Donatus , Ruan Mengyuan , Shan Zhilei , Harris Diane , Mozaffarian Dariush , Zhang Fang Fang 
Published: May 2021

Abstract
Purpose: Suboptimal diet is a preventable cause of cancer. We aimed to estimate the economic burden of diet-associated cancer among US adults. Methods: We used a Comparative Risk Assessment model to quantify the number of new cancer cases attributable to seven dietary factors among US adults ages 20+ years. A Markov cohort model estimated the 5-year medical costs for 15 diet-associated cancers diagnosed in 2015. We obtained dietary intake from 2013-2016 National Health and Nutrition Examination Survey, cancer incidence and survival from 2008-2014 Surveillance, Epidemiology, and End Results (SEER) program, and medical costs from 2007-2013 linked SEER-Medicare data. Results: The estimated 5-year medical costs of new diet-associated cancer cases diagnosed in 2015 were $7.44 (2018 US$). Colorectal cancer had the largest diet-related 5-year medical costs of $5.32B. Suboptimal consumption of whole grains ($2.76B), dairy ($1.82B) and high consumption of processed meats ($1.5B) accounted for the highest medical costs. Per-person medical costs attributable to suboptimal diet vary by gender, race and age group.Conclusions: Suboptimal diet contributes substantially to the economic burden of diet-associated cancers among US adults. This study highlights the need to implement population-based strategies to improve diet and reduce cancer burden in the US.
Association Between Weight Gain, Psychological, Sociodemographic Factors, and Physical Activity in Bariatric Patients: A Network Perspective
Authors: Vieira Nélio Barreto , Bandeira Paulo Felipe Ribeiro , Delmondes Gyllyandeson , Bertoldi Rafaela , Cunha Glacithane Lins da , Soares Nayara da Silva , Bottcher Lara Belmudes , de Almeida Roberto Lopes , Vieira Maria Eveline , Salami Sedigheh , Kerntopf Marta Regina , Martins Clarice , Zaia Victor 
Published: May 2021

Abstract
Background Weight gain affects about 10-20% of patients after bariatric surgery (BS). It’s a phenomenon that’s difficult to understand and to intervene due to its complexity and etiological heterogeneity. In the present study, we investigated, from a network analysis perspective, the associations between weight regain, psychological, sociodemographic factors and physical activity in patients undergoing BS. Methods The sample consisted of 124 patients, of both sexes, aged 39 ± 9.1 years, who had undergone surgical intervention for more than 18 months. After voluntary consent, respondents answered questionnaires and instruments directly on the Google Forms platform. Results The weight gain was negatively associated with the items of depression, anxiety and stress, binge eating and with the dimensions of the personality questionnaire (negative affectivity -0.182; detachment -0.078; antagonism -0.107; disinterest - 0.198 and psychoticism -0.158). Conclusion Characteristics of disinterest and negative affectivity and most of the items on the depression, anxiety and stress scale had a greater expected influence, indicating that these are the most sensitive variables to intervention and who need more attention from health professionals.Level of evidence: Level III, evidence obtained from well-designed case-control analytic studies.
In-Silico Evaluation and Selection of the Best 16S rRNA Gene Primers for Use in Next-Generation Sequencing to Detect Oral Bacteria and Archaea.
Authors: A Regueira-Iglesias , L Vázquez-González , C Balsa-Castro , N Vila-Blanco , T Blanco-Pintos , J Tamames , MJ Carreira , I Tomás 
Published: May 2021

Abstract
Background: Sequencing has been widely used to study the composition of the oral microbiome present in various health conditions. The extent of the coverage of the 16S rRNA gene primers employed for this purpose has not, however, been evaluated in silico using oral-specific databases. This paper analyses these primers using two databases containing 16S rRNA sequences from bacteria and archaea found in the human mouth and describes some of the best primers for each domain. Results: A total of 369 distinct individual primers were identified from sequencing studies of the oral microbiome and other ecosystems. These were evaluated against a database reported in the literature of 16S rRNA sequences obtained from oral bacteria, which was modified by our group, and a self-created oral-archaea database . Both databases contained the genomic variants detected for each included species. Primers were evaluated at the variant and species levels, and those with a species coverage (SC) ≥75.00% were selected for the pair analyses. All possible combinations of the forward and reverse primers were identified, with the resulting 4638 primer pairs also evaluated using the two databases. The best bacteria-specific pairs targeted the 3-4, 4-7 and 3-7 16S rRNA gene regions, with SC levels of 97.14-98.83%; meanwhile, the optimum archaea-specific primer pairs amplified regions 5-6, 3-5 and 3-6, with SC estimates of 95.88%. Finally, the best pairs for detecting both domains targeted regions 4-5, 3-5 and 5-9, and produced SC values of 94.54-95.71% and 96.91-99.48% for bacteria and archaea, respectively. Conclusions: Given the three amplicon length categories (100-300, 301-600 and >600 bps), the primer pairs with the best coverage values for detecting oral bacteria were: KP_F048-OP_R043 (region 3-4; primer pair position for Escherichia coli J01859.1: 342-529), KP_F051-OP_R030 (4-7; 514-1079), and KP_F048-OP_R030 (3-7; 342-1079). For detecting oral archaea, these were: OP_F066-KP_R013 (5-6; 784-undefined), KP_F020-KP_R013 (3-6; 518-undefined) and OP_F114-KP_R013 (3-6; 340-undefined). Lastly, for detecting both domains jointly they were KP_F020-KP_R032 (4-5; 518-801), OP_F114-KP_R031 (3-5; 340-801) and OP_F066-OP_R121 (5-9; 784-1405). The primer pairs with the best coverage identified herein are not among those described most widely in the oral microbiome literature.
Failure of Internal Fixation of The Anterior Ring For Unstable Pelvic Fractures, The Experience of A Single Institute
Authors: Zhang Sheng , Mo Huagui , Liu Yucheng , Zhu Guohua , Yu Bin 
Published: May 2021

Abstract
Background: This study aimed to share our experience of anterior ring fixation failure for unstable pelvic fractures and propose corresponding treatment strategies. Materials: From January 2009 to December 2018, 93 patients with pelvic fractures were retrospectively reviewed. Patients with failure of the anterior ring internal fixation within 3 months after initial surgery were analyzed. Quality of reduction was evaluated using the Majeed scoring system.Results: According to the Tile classification of fracture, there were 23 cases of type B1, 17 cases of type B2, 11 cases of type B3, 28 cases of type C1, 6 cases of type C2, and 8 cases of type C3. The duration from injury to pelvic internal fixation ranged from 5-28 days. Seven out of 93 patients experienced failure of internal fixation of the anterior pelvic ring within 3 months, including 2 patients fixed with an external fixator and 5 patients were fixed with a plate. Five patients undergoing revision surgery were followed up for 6-36 months with an average of 18 months. According to Majeedscore at the last follow-up, there were 2 cases of excellent, 2 cases of good, 1 case of fair, and the excellent and good rate reached 80%.Conclusion: The treatment of complicated unstable pelvic fractures requires early multidisciplinary cooperation, proper management of hemodynamic stability and other comorbidities, and performing internal fixation surgery within 2 weeks. It is necessary to make a preoperative plan and stabilize the posterior ring first, avoiding a single steel plate crossing the pubic symphysis.
Disc Measurement and Nucleus Calibration in a Smoothened Lumbar Model Increases the Accuracy and Efficiency of in-silico Study
Authors: Li Jingchi , Xu Chen , Zhang Xiaoyu , Xi Zhipeng , Sun Shenglu , Zhang Ke , Fang Xiaoyang , Xie Lin , Liu Yang , Song Yueming 
Published: May 2021

Abstract
Backgrounds: Finite element analysis (FEA) is an important tool during the spinal biomechanical study. Irregular surfaces in FEA models directly reconstructed based on imaging data may increase the computational burden and decrease the computational credibility. Definitions of the relative nucleus position and its cross-sectional area ratio do not conform to a uniform standard in FEA. Methods: To increase the accuracy and efficiency of FEA, nucleus position and cross-sectional area ratio were measured from imaging data. A FEA model with smoothened surfaces was constructed using measured values, nucleus position was calibrated by estimating the differences in the range of motion (RoM) between the FEA model and that of an in-vitro study. Then, the differences was re-estimated by comparing the RoM, the intradiscal pressure, the facet contact force and the disc compression to validate the measured and calibrated indicators. The computational time in different models was also recorded to evaluate the efficiency. Results: Computational results indicated that 99% of accuracy was attained when measured and calibrated indicators were set in the FEA model, with a model validation of greater than 90% attained under almost all of the loading conditions. Computational time decreased by around 70% in the fitted model with smoothened surfaces compared with that of the reconstructed model. Conclusions: The computational accuracy and efficiency of in-silico study can be guaranteed in the lumbar FEA model constructed using smoothened surfaces with measured and calibrated relative nucleus position and its cross-sectional area ratio.
Nonlinear Vibrations of Rotating Pretwisted Composite Blade Reinforced by Functionally Graded Graphene Platelets Under Combined Aerodynamic Load and Air Flow in Tip Clearance
Authors: Gu X. J. , Zhang W. , Zhang Y. F. 
Published: May 2021

Abstract
The primary resonance and nonlinear vibrations of the functionally graded graphene platelet (FGGP) reinforced rotating pretwisted composite blade under combined the external and multiple parametric excitations are investigated with three different distribution patterns. The FGGP reinforced rotating pretwisted composite blade is simplified to the rotating pretwisted composite cantilever plate reinforced by the functionally graded graphene platelet. It is novel to simplify the leakage of the air flow in the tip clearance to the non-uniform axial excitation. The rotating speed of the steady-state adding a small periodic perturbation is considered. The aerodynamic load subjecting to the surface of the plate is simulated as the transverse excitation. Utilizing the first-order shear deformation theory, von-Karman nonlinear geometric relationship, Lagrange equation and mode functions satisfying the boundary conditions, three-degree-of-freedom nonlinear ordinary differential equations of motion are derived for the FGGP reinforced rotating pretwisted composite cantilever plate under combined the external and multiple parametric excitations. The primary resonance and nonlinear dynamic behaviors of the FGGP reinforced rotating pretwisted composite cantilever plate are analyzed by Runge-Kutta method. The amplitude-frequency response curves，force-frequency response curves, bifurcation diagrams, maximum Lyapunov exponent, phase portraits, waveforms and Poincare map are obtained to investigate the nonlinear dynamic responses of the FGGP reinforced rotating pretwisted composite cantilever plate under combined the external and multiple parametric excitations.
Temperament-Based Treatment for Young Adults with Eating Disorders: Acceptability and Initial Efficacy of an Intensive, Multi-Family, Parent-Involved Treatment.
Authors: Peck Stephanie Knatz , Towne Terra , Wierenga Christina , Hill Laura , Eisler Ivan , Brown Tiffany , Han Emily , Miller McKenzie , Perry Taylor , Kaye Walter 
Published: May 2021

Abstract
Background: Adult eating disorder treatments are hampered by lack of access and limited efficacy. This open-trial study evaluated the acceptability and preliminary efficacy of a novel intervention for adults with eating disorders delivered to young adults and parent-supports in an intensive, multi-family format (Young Adult Temperament-Based Treatment with Supports; YA-TBT-S). Methods: 38 YA-TBT-S participants (m age = 19.58; SD 2.13) with anorexia nervosa (AN)-spectrum disorders, bulimia nervosa (BN)-spectrum disorders, and avoidant/restrictive food intake disorder (ARFID) completed self-report assessments at admission, discharge, and 12-month follow-up. Assessments measured program satisfaction, eating disorder psychopathology and impairment, body mass index (BMI), and trait anxiety. Outcomes were analyzed using linear mixed effects models to examine changes in outcome variables across diagnoses over time. Results: Treatment was rated as highly satisfactory. 53.33% were in partial or full remission at 12-month follow-up. Participants reported reductions in ED symptomatology (AN and BN), increases in BMI (AN and ARFID), and reductions in clinical impairment (AN and ARFID) at 12-month follow-up. Conclusions: YA-TBT-S is a feasible and acceptable treatment that may improve ED outcomes in young adults with a broad range of diagnoses. Further evaluation of efficacy is needed in larger samples, and to compare YA-TBT-S to other ED treatment approaches.
Integrating WaTEM/SEDEM model and GIS-based FAHP Method for Identifying Ecological Rainwater Harvesting Sites in Ziz upper watershed, SE Morocco
Authors: Manaouch Mohamed , Mohamed Sadiki , Imad Fenjiro 
Published: May 2021

Abstract
Moroccan southeast areas have limited water ressources, vulnerable to climate change and characterized by a significant spatio-temporal variability. In response, to ensure the availability of water for local comunity, it is advised to develop some alternatives that improve the local water resources management throughout these areas. Rainwater harvesting (RWH) has been used widely as an alternative technique towards water scaricity. However, taking into account socio-economic constraints for identifying ecological sites for RWH remains a complex task for water managers. The present study was conducted using WaTEM/SEDEM model, GIS techniques and Fuzzy Analytical Hierarchy Process (FAHP) method to identify important ecological RWH sites. For this purpose, several data sources were employed to generate needful thematic layers. The soil conservation service curve number (SCS-CN) method was utilized for preparing a yearly runoff potential map. Then, the thematic layers were weighted for generating RWH suitability map. The results show that yearly surface runoff ranges from 136 to 500 mm. Moreover, the spatial distribution map of soil erosion of WaTEM/SEDEM shows that Ziz upper watershed can be classed into four classes: (i) slight (very suitable), (ii) moderate (suitable), (iii) high (less suitable) and (iv) severe (not suitable). Aproximatly 76.1% of the study area falls within slight soil erosion class. The GIS tools were used for generating the important ecological RWH suitability map. The GIS’s intersect tool was used to eliminate insuitable soil erosion classes and the buffer tool was used for integrating the socio-economic factors including the distance from residential areas and agriculltural fields. Prediction accuracy of the resultant map of RWH suitability showed the value of the area under the curve (AUC) equal to 59.6% for FAHP method in this study. Ecological RWH map, mainly, introduced western areas and some central parts of Ziz upper watershed as suitable RWH areas. The present study demonstrated that coupling WaTEM/SEDEM model with FAHP method and GIS tools provide a valuable approach for identifying the ecological RWH sites in large semi-arid areas.
Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series
Authors: Yang Sishu , Lu Jiong , Cai Yulong , Li Bei , Xiong Xianze 
Published: May 2021

Abstract
Background

Mixed adenoneuroendocrine carcinoma is a rare clinical manifestation, especially in the gastric and ampullary. The purpose of this study was to investigate the clinicopathological features and prognosis of mixed adenoneuroendocrine carcinoma in the gastric and ampullary and summarize related treatment suggestions.
Methods

In all, 32 cases of mixed adenoneuroendocrine carcinoma in the gastric and ampullary that were diagnosed from resected specimens were analyzed from 2009–2015. The corresponding demographic, clinicopathological and survival data were retrospectively reviewed.
Results

The 1-year, 3-year and 5-year survival rates were 78.1%, 28.1% and 9.4%, respectively, and the median overall survival was 28.0 months. In all, 75.0% (24/32) had lymph node metastasis at the time of initial diagnosis. A multivariate analysis revealed that TNM stage(HR6.444 95%CI 1.477–28.121 P = 0.013), lymph nodes metastasis (HR10.617 95%CI 1.409–79.997 P = 0.022), vascular invasion (HR 5.855 95%CI 1.719–19.940 P = 0.005),grade of the adenocarcinoma component (HR 3.876 95% CI 1.451–10.357 P = 0.007) and CD56 positivity (HR 0.265 95% CI 0.100-0.705 P = 0.008)were independent predictors of overall survival.
Conclusions

Mixed adenoneuroendocrine carcinoma is an aggressive clinical entity with a poor prognosis. Taking both the neuroendocrine component and the adenocarcinoma component into consideration of optimal treatment is strongly recommended.
WITHDRAWN: Intraarticular Injection of Different Doses of Mesenchymal Stem Cell Derived Exosomes Reduces ATF-3 Expression in the Dorsal Root Ganglion in Monoiodoacetate-Induced Rats of Osteoarthritis
Authors: Zhou Wenwen , Wang Lin , Cao Qilong , LI Xinhe , Hu Yue , Li Juan , Li Tieshan 
Published: May 2021

Abstract
Background: This study aims to evaluate the therapeutic effect of intra-articular injection of different doses of exosomes derived from mesenchymal stem cells(MSC) and the effect on nerve and cartilage repair in a monoiodoacetate (MIA) model of knee osteoarthritis(OA) in rats. Methods: The pain rat model was established by injection of sodium monoiodate (MIA) into the knee joint of the rats, the knee joint and dorsal root ganglion (DRG) of rats were collected for histologic analyses. For pain assessment, On 1 day before MIA injection, 7, 14 days after MIA injection and 7, 14,28 days after Exosome injection,paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) was measured. Articular cartilage were assessed on HE by ORASI grade and the expression of ATF-3 and GAP-43 in dorsal root ganglion (DRG) using immunohistochemistry and western blotting in MIA-induced rats. Results: In our study, exosome significantly improved PWT and PWL value with a dose-dependent manner on 7, 14, and 28 days after intra-articular Exosome compared with the MIA group. Exosome injection therapy also has a repairing effect on cartilage on 28 days after intra-articular Exosome compared with the MIA group. Moreover, exosome treatment significantly upregulated GAP-43 protein and downregulated ATF-3 protein in the DRG with a dose-dependent manner of the OA rat. Conclusion: Intraarticular injection of different doses of mesenchymal stem cell derived exosomes in MIA-induced rats osteoarthritis, the analgesic effect of exosome was dose-dependent. Moreover, the repair of nerve by exosomes is earlier than that of cartilage.
Assessing Problematic Facebook Use: Psychometric Properties of the Polish Version of Facebook Intrusion Questionnaire
Authors: Błachnio Agata , Przepiórka Aneta , Cudo Andrzej , Elphinston Rachel A. 
Published: May 2021

Abstract
BackgroundFacebook is used for work, entertainment and communication. However, there is potential for problematic or addictive use which can cause significant mental and physical health problems. The Facebook Intrusion Questionnaire (FIQ; Elphinston & Noller, 2011) is one of the most widely used measures of problematic Facebook use. However, no previous study has validated this measure in a Polish population. MethodsThe study aims to validate the Polish adaptation of FIQ. Five large samples of Polish Facebook users (N = 12,753; M age = 21 years; 66% female) were used to examine the psychometric properties of the Polish version of the FIQ. ResultsAn exploratory and confirmatory factor analysis provided support for a unidimensional factor structure (χ2(16) = 199.53, p< 0.001; RMSEA = 0.042; SRMR = 0.022; CFI = 0.950). Item response theory showed that the adapted FIQ items had adequate discrimination and information levels. ConclusionThe Polish version of the FIQ showed good internal consistency and adequate construct validity. Overall, the findings suggest that the FIQ is a reliable and valid measure for use in the Polish population.
Properties of Humic Acids in Meadow Soils Irrigated With the Slope-And Flooding System
Authors: Banach-Szott Magdalena , Dziamski Andrzej 
Published: May 2021

Abstract
The aim of the research has been to determine the effect of many-year irrigation of unique grasslands on the properties of humic acids defining the quality of organic matter. The research was performed based on the soil (Albic Brunic Arenosol, the A, AE and Bsv horizons) sampled from Europe’s unique complex of permanent grasslands irrigated continuously for 150 years, applying the slope-and-flooding system; the Czerskie Meadows. The soil samples were assayed for the content of total organic carbon (TOC) and the particle size distribution. HAs were extracted with the Schnitzer method and analysed for the elemental composition, spectrometric parameters in the UV-VIS range, hydrophilic and hydrophobic properties and the infrared spectra were produced. The research results have shown that the HAs properties depended on the depth and the distance from the irrigation ditch. The HAs of the A horizon of the soils were identified with a lower “degree of maturity”, as reflected by the values of atomic ratios (H/C, O/C, O/H), absorbance coefficients, and the FT-IR spectra, as compared with the HAs of the Bsv horizon. The HAs molecules of the soils sampled furthest from the irrigation ditch were identified with a higher degree of humification, as compared with the HAs of the soils sampled within the closest distance. The results have demonstrated that many-year grassland irrigation affected the structure and the properties of humic acids.