bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Apatinib Treatment for Advanced Cholangiocarcinoma After Failed Gemcitabine-Based Chemotherapy: An Open-Label Phase II Prospective Study
Authors: Zhang Ge , Gong Shuai , Pang Lina , Hou Lixia , He Wei 
Published: May 2021

PurposeAs a novel small-molecule vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor (VEGFR2-TKI), Methylsulfonic apatinib (apatinib) exhibits a specific antitumor effect in various solid tumors via inhibition of angiogenesis. The present study was performed to evaluate the clinical efficacy and safety of apatinib in the treatment of advanced cholangiocarcinoma after failed gemcitabine-based chemotherapy.Patients and MethodsThis was a prospective open-label phase II trial (NCT03521219). A total of 32 patients, in whom gemcitabine-based first-line chemotherapy for advanced intrahepatic cholangiocarcinoma had failed, were consecutively enrolled in a prospective, open, exploratory, and single-center clinical trial from November 2017 to November 2018. They were treated with apatinib mesylate second-line monotherapy (orally, 500 mg per day for a cycle of 28 days) until progressive disease or unacceptable toxicity. Using Response Evaluation Criteria in Solid Tumor version 1.1 (RECIST 1.1) and the Common Terminology Criteria for Adverse Events version 4.0 (NCI-CTCAE 4.0), the efficacy and adverse were evaluated, respectively. Kaplan-Meier method was used for survival analysis.ResultsTwenty-six patients were enrolled in full analysis set. At the end of follow-up, two patients were lost to follow-up, 24 of 26 patients in FAS were included in efficacy analyses. For the efficacy analysis set, the objective response rate (ORR) was 20.8% [95% confidence interval (CI): 9.24–40.47%] and the disease control rate (DCR) was 62.5% (95% CI: 112.86–387.14 days). One patient (4%) showed complete response (CR), 4 patients (17%) showed partial response (PR), 10 patients (41.7%) stable disease (SD), and 9 patients (37.5%) had progressive disease (PD). Meanwhile, apatinib therapy achieved the median progression-free survival PFS was 95 days (95% CI: 79.70–154.34 days), and the median OS was 250 days (95% CI: 112.86–387.14 days). Furthermore, univariate analysis revealed that age and tumor’s anatomic location significantly affected PFS (P &lt; 0.05). The most common clinically adverse events (AEs) included myelosuppression (69.2%), hypertension (57.7%), proteinuria (46.2%). The AEs were mild, mainly in grade 1 or 2, and no toxicity-induced death occurred.ConclusionApatinib monotherapy is an effective and promising regimen for treating patients with advanced cholangiocarcinoma who experienced failure of gemcitabine-based chemotherapy.
Religious work of the Nayanmars who volunteered for the sacred offering of Food
Authors: P Sasireha 
Published: May 2021

Food is one of the basic elements needed to live a healthy life in the world. The body needs food to survive and food to survive. Only a healthy body can function with energy. The body also acts as a bridge to help the living reach the Lord. Sixty-three of the Nayans expressed their love for the Lord through their charities. It is noteworthy that the work done by a large number of ten Nayans was done by a large number of Nayans, although the Nayans practiced as many religious activities as they wished, providing foods, such as lighting, plowing, supplying, and providing clothing. Although there are many ways to practice religion, the Nayans amused the devotees who realized that the energy capacity of food was essential for the functioning of the body. This article sets out to explore the religious work of the Nayans who volunteered for such an amulet.
KECERNAAN BAHAN KERING, RETENSI NITROGEN DAN ENERGI METABOLIS RANSUM AYAM PEDAGING YANG MENGGUNAKAN TEPUNG LIMBAH LABU KUNING (Cucurbita moschata)
Authors: Herryanto Ryan Hendrik , Mandey Jet S. , Untu Ivonne M. , Rahasia Cathrien A. 
Published: May 2021

DIGESTIBILITY OF DRY MATTER, NITROGEN RETENTION AND METABOLIC ENERGY IN RATION OF BROILERS USING YELLOW PUMPKIN MEAL (Cucurbita moschata). Research was conducted to evaluate digestibility of dry matter, nitrogen retention and metabolic energy corrected to nitrogen in ration of broilers using yellow pumpkin meal (Cucurbita moschata). The total of 20 unsexed broilers of CP 707 strain at age of 5 weeks old with the average body weight of 1073 grams were used in this study. The completely randomized design involving 4 treatments and 5 replications in each treatment was applied at the experimental unit. The significant treatments were tested using honestly significant difference test. The treatments were including 100% basal ration without yellow pumpkin meal (R0), 95% basal ration added with 5% yellow pumpkin meal (R1), 90% basal ration added with 10% yellow pumpkin meal (R2), and 85% basal ration added with 15% yellow pumpkin meal (R3). Results of analysis of variance showed that treatments significantly affected (P<0,05) nitrogen retention value, but did not significantly affected (P>0,05) dry matter digestibility and metabolic energy corrected to nitrogen in ration. Based on honestly significant difference test, treatments of R0, R1 and R2 were higher compared with R3. Among treatments of R0, R1 and R2 were not significantly different. Therefore, it can be concluded that yellow pumpkin meal (Cucurbita moschata) was potential to be the alternative material ingredient up to 15 percents in ration of broilers based on digestibility of dry matter, nitrogen retention and metabolic energy. Key Words: Broiler, Dry matter, Metabolic energy, Nitrogen retention, Yellow pumpkin meal.
KARATERISTIK ORGAN BAGIAN DALAM AYAM BURAS YANG DIBERI PAKAN MINYAK KELAPA (Cocos nucifera) DALAM RANSUM
Authors: Leke Jein Rinny , Sompie F.N. , Wantasen E. , Widyastuti T. , Sondakh E.H.B. 
Published: May 2021

INTERNAL ORGANS CHAR ACTERISTICS OF NATIVE CHICKEN FED BY COCONUT OIL (Cocos nucifera) ON DIET. The research was carried to determine the internal organs characteristics of buras chickens fed coconut (Cocos mucifera) oil in diet. A total 100 unsexed buras chickens was used in this experiment. The design used in this study was a completely randomized design (CRD) consisting of 5 treatments and 5 replications (4 hens each). The data were subjected to analysis of variance, when the treatments indicated significant effect it was continued Duncan’s Multiple Range Test. Five dietary treatments containing 0, 0.5%, 1 %, 1,5%, and 2% levels of coconut oil (CO) with five replicates were applied to chickens. Parameters measured were body weight, heart, liver, pancreas and gizzard weight. Result showed that CO in the ration significantly increased the body weight (P<0.01) but did not affect to heart weight, liver weight, pancreas weight and gizzard weight.(P>0.05) It can be concluded that coconut oil in the diet can’t increase the internal organ characteristics. We can gave the 2% CO in the diet for the best results. Key words: Internal Organs, Coconut Oil, Buras Chickens
KUALITAS INTERNAL TELUR AYAM MB 402 YANG DIBERI RANSUM DENGAN IMBANGAN PROTEIN DAN ENERGI BERBEDA
Authors: Arunde Jerlania M. , Leke Jein Rinny , Rimbing S. , Tangkau L. 
Published: May 2021

This study aims to study the internal quality of chicken eggs MB 402 feed with different protein and energy balance. A total of 80 MB 402 chicken aged 38 weeks with the treatment given (P1 15% protein, 2800 kkcal/kg energy metabolisme), (P2: 16% protein, 2800 kcal/kg energy metabolisme), (P3: 17% protein, 2700 kcal/kg energy metabolisme) dan (P4: 18%, protein 2700 kcal/kg energy metabolisme). The design used is a complete random design (RAL) with 4 treatment 5 replications in each treatment there were 4 MB 402 laying hens. Research variabeles include : egg yolk index, egg yolk colour, and egg white index. The results showed that the protein and energy balance in the ration had no real effect (P > 0,05) to the color of the yolk, the index of the index of the yolk, and theo0 index of the egg whites. Conclusions the use of protein and energy balance in ration with level 15% protein and 2800 kcal/kg energy metabolise. Keywords: laying hens MB 402, Protein and energy balance, Egg quality
PENGARUH PENGGANTIAN SEBAGIAN RANSUM DENGAN TEPUNG LIMBAH LABU KUNING (Cucurbita moschata) TERHADAP PERFORMANS AYAM PEDAGING
Authors: Salauhiang Julin , Najoan Marie , Pontoh Cherly J. , Imbar Meity R. 
Published: May 2021

EFFECT OF REPLACEMENT SOME RATIONS WITH FLOUR YELLOW PUMPKIN WASTE (CUCURBITA MOSCHATA) AGAINST PERFORMANCE BROILER. This study aims to determine the extent of the partial replacement of rations with pumpkin waste flour (Cucurbita moschata) as measured by broiler performance. Using 100 unsexed broiler Cobb 707 aged 1 day with average body weight ± 45.32 g. The design used was a Completely Randomized Design (CRD) consisting of 4 treatments and 5 replications. The treatment composition is as follows: R0 = 100% basal ration (RB) + 0% pumpkin waste flour (TLLK), R1 = 95% RB + 5% TLLK, R2 = 90% RB + 10% TLLK, R3 = 85% RB + 15% TLLK. Results of analysis of variance showed that the dissecting treatment was not significant (P>0.05) for the consumption, weight and conversion of ration The use of pumpkin waste flour can replace a portion of the ration up to 15%.Key words: Performance, waste pumpkin, broiler.
PENGARUH FALSE MOUNTING TERHADAP KUALITAS SEMEN SAPI LIMOUSIN DAN SIMMENTAL DI BALAI INSEMINASI BUATAN LEMBANG
Authors: Kafiar Yuli Siska , Adiani Sri , Lomboan Agustinus , Lapian H.F.N. 
Published: May 2021

THE EFFECT OF FALSE MOUNTING ON SEMEN QUALITY OF LIMOUSIN AND SIMMENTAL BULL IN LEMBANG ARTIFICAL INSEMINATION CENTER. The purpose of this study was to determine the effect of false mounting on the quality of Limosin and Simental bull semen at the Lembang Artificial Insemination Center. The 55 individu of Limousin and 55 Simmental bull aging 5-9 years old have been used in thos study. The data have been collected directly in the Artificial Insemination Center Lembang - West Java Province. The data obtained in the form of macroscopic and microscopic observations on Limousin and Simmental bull include volume, pH, mass movement, spermatozoa motility and spermatozoa concentration. Data were analyzed descriptively by calculating the standard deviations, correlations coefficients and the T test. The variables measured in this study were macroscopic and microscopic quality of semen. The results of this study indicate that the effect of false mounting on the average semen volume of Limousin and Simmental bull is maximum at 3, 4, and 5 times false mounting but there was not significantly difference between the amount of false mounting, as well as the average volume, pH, mass movement, motility of spemetozoa and concentration spermatozoa are not significantly different. It was concluded that false mounting in Limousin and Simmental bulls in Lembang Artificial Insemination Center had no significantly effect on the quality of macroscopic and microscopic semen. Keywords: False Mounting, Cement Quality, Limousin Cattle, Simmental Cows.
PENGARUH PEMANFAATAN BONGGOL PISANG SEPATU (Musa paradisiaca L) DALAM RANSUM TERHADAP PERSENTASE KARKAS DAN LEMAK ABDOMINAL AYAM BROILER
Authors: Pontoh Sulastri G. , Mandey J. , Wolayan F.R. , Kowel Y. 
Published: May 2021

THE INFLUENCE OF THE USE OF BANANA HUMP SHOES (Musa paradisiaca L) IN RATION ON THE PERCENTAGE OF CARCASS AND ABDOMINAL FAT IN BROILER CHICKEN. This study aims to determine the extent of the effect of using banana hump shoes (Musa Paradisiaca) in rations on carcass and abdominal fat in broiler chickens. This study was conducted using 100 unsexed Cobb broiler chickens (PT. Charoen Pokhpand), with an average body weight of 837 grams. The design used was a Completely Randomized Design (CRD) consisting of 4 treatments and 5 replications. Arrangement of the experimental treatment as follows: R₀= 55% corn + 0% banana hump shoes, R₁= 50% corn + 5% banana hump shoes, R₂= 45% corn + 10% banana hump shoes, R₃= 40% corn + 15% banana hump shoes. The results showed that there was no significant difference (P>0,05) on the percentage of carcass and abdominal fat in broiler chickens. Based on the results of this study it can be concluded that the use of banana shoe hump in rations up to 15% produces a good percentage of carcass and abdominal fat. Keywords: broiler chicken, banana hump shoes, percentage of carcass and abdominal fat.
INFESTASI KUTU PADA AYAM KAMPUNG (Gallus gallus domestic) DI DESA TOLOK KECAMATAN TOMPASO KABUPATEN MINAHASA
Authors: Balaira Hartina S. , Assa G.V.J. , Nangoy F.J. , Sarajar C.L.K , Nangoy Meis 
Published: May 2021

LOUSE INFESTATION AT LOCAL LAYING HENS (Gallus gallus domestic) AT TOLOKVILLAGE TOMPASO DISTRICT OF MINAHASA REGENCY. The objective of this study was to count the infestation, preference of this louse on parts of the body and sex of birds, The purposive random sampling method was used in sample collection implemented manually on the birds stated in the morning and in the afternoon by screening all body of birds initiated from head, neck, hip, abdomen, thigh, and tail using all fingers. Samples of louses found were filled into bottle containing alcohol of 70%. Samples of louses were counted. Result showed that the parasite found one type of louse (Menopon gallinae) with preference infestation of 87.5% from 40 local laying hens spreading on the body parts of birds in the average frequencies on hip of birds about 6.23 louses/bird, on neck of bird about 3.43 louse/bird, on abdomen of bird about 5.48 louses/bird, on thigh about 0.83 louses/bird and on tail about 1.28 louses/bird. The preference of parasite was found on female bird with the average of 20.35 louses/female bird and 14.10 louse/male bird. Key words: Infestation, louses, local laying hens.
PERANAN PENYULUH PADA PEMELIHARAAN TERNAK BABI LOKAL DI DESA GUMBO KECAMATAN TIOMNERI KABUPATEN LANNY JAYA
Authors: Jigibalom Turi , Malingkas J A , Oley F S , Lombogia S O.B 
Published: May 2021

ROLE OF CATTLE PIGS COUNSELORS MAINTENANCE OF LOCAL DISTRICT IN THE VILLAGE GUMBO TIOMNERI LANNY JAYA REGENCY. The study aims to determine characteristics and breeders perception toward extension activities in the District Gumbo village Tiomneri Lanny Jaya Regency Research has implemented since December, 1th until January 31th 2018 using survey method. Twenty two of pig breeders in the village pig farmers Gumbo Tiomneri District of Lanny Jaya Regency was selected by census as sample of respondents. Data analysis using scale of likert Study results indicated that breeders perception of the role of agriculture extension agent as a motivator and facilitator in the District Gumbo village Tiomneri Lanny Jaya Regency was already optimal, or in other words the role of extension officers in performing their duties was already good. The process of adoption of technology by pig farmers in the village of the District Gumbo Tiomneri Lanny Jaya Regency was varied from respondents..The role agriculture counselor as a motivator has succeed to change the habits of farmers tradition that used to keep cattle in the house where they live (home honai) but by now farmers have made pig pen outside their house.Keywords: Role of Extension agent, pigs, Gumbo..
ISOLASI SENYAWA SESQUITERPEN DARI FRAKSI AKTIF ANTIBAKTERI ALGA LAUT MERAH Laurencia tronoi
Authors: Dotulong Verly 
Published: May 2021

Tujuan penelitian ini adalah mendapatkan “senyawa baru yang diisolasi dari fraksi aktif antibakteri yaitu fraksi heksana alga laut merah laurencia tronoi, sehingga alga laut ini dapat dikembangkan sebagai pangan fungsional”. Metode ekstraksi yang digunakan adalah maserasi dengan metanol-air 50%, pada ekstrak metanol air dilakukan fraksinasi berkesinambungan dengan menggunakan pelarut n-heksana, etilasetat dan air. Fraksi n-heksana yang mempunyai aktivitas antibakteri tertinggi selanjutnya dimurnikan untuk mendapatkan isolat murni dengan menggunakan kromatografi kolom sebanyak 3 tahap. Pendeteksian hasil pemisahan pada tiap tahap dilakukan dengan menggunakan kromatografi Lapis tipis. Pemisahan tahap 1 dan 2 menggunakan fasa diam silika gel 60F254 dan fasa gerak heksana-etilasetat, sedangkan pemisahan tahap ke-3 menggunakan fasa diam silika gel 60F254 RP-18 dan fasa gerak air-metanol hingga didapatkan isolat murni. Karakterisasi struktur isolat murni menggunakan metode spektrokopi NMR. Isolat murni yang dihasilkan berupa padatan amorf berwarna putih dengan hasil interpretasi terhadap spectrum H-NMR, C-NMR, DEPT, HMQC, HMBC dan COSY adalah termasuk golongan senyawa sesquiterpen mempunyai rumus molekul C15H26O4 mempunyai nama IUPAC 3,3,9a-trimetil-6-metilen-dekahidro-1H-benzo[7] annulen-1,2,4a,8-tetraol. Isolat murni ini diduga adalah senyawa baru karena berdasarkan penelusuran literatu belum ditemukan struktur yang sama dengan struktur isolat murni yang dihasilkan dalam penelitian ini.
Legal Aspects of Digital Platforms for the Sharing Consumption Economy
Authors: Altukhov A. V. , Gostilovich A. O. , Kashkin S. Yu. 
Published: May 2021

Aim. To consider the features of the shared consumption phenomenon that require specialized legal regulation.Tasks. To highlight the problems of the legislative framework in this area; to give suggestions for solving the identified problems.Methodology. The study was conducted in the context of the economic and legal science theory and methodology, using methods of information synthesis and analysis, expert evaluation; scientific and popular scientific publications of domestic and foreign authors were researched.Results. The concept of the shared consumption economy is revealed. The legal aspects of digital platforms for the shared consumption economy are considered, the experience of the European Union (EU) and the results of the Russian Federation (RF) achieved in this area are analyzed. Based on the analysis, the authors propose to apply the principles and mechanisms of integration law for the regulatory regulation of the new socio-economic model.Conclusions. It is shown that integration law will best use the accumulated practical experience of legal mechanisms’ timely adaptation to the variability of the external environment in the conditions of digital transformation and artificial intelligence. It is concluded that the concept of “good governance” can be successfully used for the legal regulation of the shared consumption economy platforms.
Reformatting the Social Contract in the Context of a Pandemic
Authors: Leontieva A. N. 
Published: May 2021

Aim. The presented study aims to identify the most significant changes in the global and national development agenda associated with the impact of the coronavirus pandemic.Tasks. The authors analyze the performance of the financial sector; summarize the assessments of leading consulting companies and the results of public opinion polls regarding the actual and projected state of the global and Russian economy and changes in consumption patterns; determine challenges that national authorities are currently facing.Methods. This study uses general scientific methods of cognition: observation, generalization, comparison, deduction and induction, methods of institutional and structural analysis.Results. Major trends of socio-economic development during the post-crisis period are examined and analyzed; factors affecting changes in the social structure and potential directions of managerial influence are determined.Conclusions. The 2020 coronavirus pandemic has been a huge stress for the established management systems at all levels, generating additional public demands that need to be reflected in the social contract. Changes in the main trends of socio-economic development caused by quarantine measures determine the parameters of a different environment for national and social development. Production and industry are affected by regionalization, while consumption is becoming increasingly globalized. Human capital is undergoing transformation in response to the digitalization of the economy, which creates the prerequisites for increasing inequality.
Factoring as a Method of Funding Commercial Companies
Authors: Vtorygin A. S. 
Published: May 2021

Aim. The presented study aims to examine the essence of factoring and explore potential directions for its development in the current economic environment.Tasks. The authors determine the economic substance of factoring, making allowance for the turbulence of the global market environment and the impact of new challenges for the Russian economy.Methods. This study analyzes legislative and regulatory acts as well as works of Russian and foreign scientists regarding the theoretical and practical problems of funding companies through factoring.Results. The factoring market is actively developing, particularly at the times of macroeconomic instability, which slows the turnover of funds in the economy and increases the need for funding sources among market participants. The stability of the factoring market during the COVID crisis serves to illustrate the heightened interest of business entities in factoring as a tool for solving a number of problems in corporate financial management. Some characteristic trends in the development of the Russian factoring market include its synchronization with the international market, active development of blockchain technologies, growing number of market participants and expanding range of services provided within the framework of factoring transactions.Conclusions. Having summarized the theory and practice of factoring development in Russia and abroad, the author concludes that factoring retains its potential as a tool for funding commercial organizations in the context of the development of digital technologies. The demand for factoring services among business entities will continue to grow in the post-COVID economy, which substantiates the practicability of further developing the factoring market and improving the technology behind factoring transactions.
ANALISA DAN PERANCANGAN WEBSITE SDN KARAWANG KULON
Authors: Noviyanthi Erlina , Suhada Karya 
Published: May 2021

Abstrak
Ilmu pengetahuan dan teknologi informasi berkembang cukup pesat dan menghasilkan inovasi-inovasi baru yang senantiasa terus berubah ke arah yang lebih baik. Informasi menjadi kata kunci dalam berbagai aspek kehidupan. Siapa yang dapat menguasai informasi, baik penguasaan dalam proses penyajian, maupun mendapatkan, ia akan bisa tampil survive di tengah persaingan yang sedemikian ketat. Dengan alasan inilah perhatian terhadap proses informasi menjadi sangat ditekankan. Sistem Informasi Sekolah adalah suatu tatanan yang berhubungan dengan penyampaian informasi akan kebutuhan informasi sekolah dari berbagai pihak. Tujuan dari perancangan ini diharapkan dapat memberikan kemudahan bagi berbagai pihak dalam memperoleh informasi secara lebih cepat dan akurat.Metodologi yang digunakan penulis dalam pembahasan ini adalah metode studi pustaka yang meliputi mengumpulkan, membaca dan mempelajari buku-buku yang menunjang materi pembuatan skripsi melalui buku-buku, serta artikel-artikel internet. Selain itu digunakan juga metode perancangan dan merancangan layar-layar tampilan yang akan dipakai dalam website yang dibangun, mengevaluasi sistem dengan cara di implementasikan. Sebagai rancangannya tool yang digunakanyaitu Macromedia Dreamweaver dan MySQL sebagai databasenya. Dengan demikian penulis berharap dengan adanya website ini, dapat meningkatkan pelayanan akan suatu informasi kepada seluruh pihak, baik saat ini maupun di masa yang akan datang. Dan benar-benar dapat bermanfaat bagi para guru, siswa maupun staf-staf yang bekerja.
Kata Kunci : Sistem Informasi, Sekolah, Website