bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duality-invariant extensions of Einstein-Maxwell theory
Authors: Cano Pablo A. , Murcia Ángel 
Published: August 2021

Abstract
We investigate higher-derivative extensions of Einstein-Maxwell theory that are invariant under electromagnetic duality rotations, allowing for non-minimal couplings between gravity and the gauge field. Working in a derivative expansion of the action, we characterize the Lagrangians giving rise to duality-invariant theories up to the eight-derivative level, providing the complete list of operators that one needs to include in the action. We also characterize the set of duality-invariant theories whose action is quadratic in the Maxwell field strength but which are non-minimally coupled to the curvature. Then we explore the effect of field redefinitions and we show that, to six derivatives, the most general duality-preserving theory can be mapped to Maxwell theory minimally coupled to a higher-derivative gravity containing only four non-topological higher-order operators. We conjecture that this is a general phenomenon at all orders, i.e., that any duality-invariant extension of Einstein-Maxwell theory is perturbatively equivalent to a higher-derivative gravity minimally coupled to Maxwell theory. Finally, we study charged black hole solutions in the six-derivative theory and we investigate additional constraints on the couplings motivated by the weak gravity conjecture.
Target space entanglement in quantum mechanics of fermions and matrices
Authors: Sugishita Sotaro 
Published: August 2021

Abstract
We consider entanglement of first-quantized identical particles by adopting an algebraic approach. In particular, we investigate fermions whose wave functions are given by the Slater determinants, as for singlet sectors of one-matrix models. We show that the upper bounds of the general Rényi entropies are N log 2 for N particles or an N × N matrix. We compute the target space entanglement entropy and the mutual information in a free one-matrix model. We confirm the area law: the single-interval entropy for the ground state scales as $$ \frac{1}{3} $$

1
3

log N in the large N model. We obtain an analytical $$ \mathcal{O}\left({N}^0\right) $$
O

N
0

expression of the mutual information for two intervals in the large N expansion.
Transcriptome programs involved in the development and structure of the cerebellum
Authors: Farini Donatella , Marazziti Daniela , Geloso Maria Concetta , Sette Claudio 
Published: August 2021

AbstractIn the past two decades, mounting evidence has modified the classical view of the cerebellum as a brain region specifically involved in the modulation of motor functions. Indeed, clinical studies and engineered mouse models have highlighted cerebellar circuits implicated in cognitive functions and behavior. Furthermore, it is now clear that insults occurring in specific time windows of cerebellar development can affect cognitive performance later in life and are associated with neurological syndromes, such as Autism Spectrum Disorder. Despite its almost homogenous cytoarchitecture, how cerebellar circuits form and function is not completely elucidated yet. Notably, the apparently simple neuronal organization of the cerebellum, in which Purkinje cells represent the only output, hides an elevated functional diversity even within the same neuronal population. Such complexity is the result of the integration of intrinsic morphogenetic programs and extracellular cues from the surrounding environment, which impact on the regulation of the transcriptome of cerebellar neurons. In this review, we briefly summarize key features of the development and structure of the cerebellum before focusing on the pathways involved in the acquisition of the cerebellar neuron identity. We focus on gene expression and mRNA processing programs, including mRNA methylation, trafficking and splicing, that are set in motion during cerebellar development and participate to its physiology. These programs are likely to add new layers of complexity and versatility that are fundamental for the adaptability of cerebellar neurons.
Semicontinuity of Gauss maps and the Schottky problem
Authors: Codogni Giulio , Krämer Thomas 
Published: August 2021

AbstractWe show that the degree of Gauss maps on abelian varieties is semicontinuous in families, and we study its jump loci. As an application we obtain that in the case of theta divisors this degree answers the Schottky problem. Our proof computes the degree of Gauss maps by specialization of Lagrangian cycles on the cotangent bundle. We also get similar results for the intersection cohomology of varieties with a finite morphism to an abelian variety; it follows that many components of Andreotti–Mayer loci, including the Schottky locus, are part of the stratification of the moduli space of ppav’s defined by the topological type of the theta divisor.
Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971
Authors: Ramakrishnan Nisha K. , Hird Matthew , Thompson Stephen , Williamson David J. , Qiao Luxi , Owen David R. , Brooks Allen F. , Scott Peter J. H. , Bacallado Sergio , O’Brien John T. , Aigbirhio Franklin I. 
Published: August 2021

Abstract
Purpose
Positron emission tomography (PET) studies with radioligands for 18-kDa translocator protein (TSPO) have been instrumental in increasing our understanding of the complex role neuroinflammation plays in disorders affecting the brain. However, (R)-[11C]PK11195, the first and most widely used TSPO radioligand has limitations, while the next-generation TSPO radioligands have suffered from high interindividual variability in binding due to a genetic polymorphism in the TSPO gene (rs6971). Herein, we present the biological evaluation of the two enantiomers of [18F]GE387, which we have previously shown to have low sensitivity to this polymorphism.

Methods
Dynamic PET scans were conducted in male Wistar rats and female rhesus macaques to investigate the in vivo behaviour of (S)-[18F]GE387 and (R)-[18F]GE387. The specific binding of (S)-[18F]GE387 to TSPO was investigated by pre-treatment with (R)-PK11195. (S)-[18F]GE387 was further evaluated in a rat model of lipopolysaccharide (LPS)-induced neuroinflammation. Sensitivity to polymorphism of (S)-GE387 was evaluated in genotyped human brain tissue.

Results
(S)-[18F]GE387 and (R)-[18F]GE387 entered the brain in both rats and rhesus macaques. (R)-PK11195 blocked the uptake of (S)-[18F]GE387 in healthy olfactory bulb and peripheral tissues constitutively expressing TSPO. A 2.7-fold higher uptake of (S)-[18F]GE387 was found in the inflamed striatum of LPS-treated rodents. In genotyped human brain tissue, (S)-GE387 was shown to bind similarly in low affinity binders (LABs) and high affinity binders (HABs) with a LAB to HAB ratio of 1.8.

Conclusion
We established that (S)-[18F]GE387 has favourable kinetics in healthy rats and non-human primates and that it can distinguish inflamed from normal brain regions in the LPS model of neuroinflammation. Crucially, we have reconfirmed its low sensitivity to the TSPO polymorphism on genotyped human brain tissue. Based on these factors, we conclude that (S)-[18F]GE387 warrants further evaluation with studies on human subjects to assess its suitability as a TSPO PET radioligand for assessing neuroinflammation.
Further research on the clinical relevance of the ulcerative colitis colonoscopic index of severity for predicting 5-year relapse
Authors: Ishida Natsuki , Onoue Shunya , Miyazu Takahiro , Tamura Satoshi , Tani Shinya , Yamade Mihoko , Iwaizumi Moriya , Hamaya Yasushi , Osawa Satoshi , Furuta Takahisa , Sugimoto Ken 
Published: August 2021

Abstract
Purpose
The ulcerative colitis colonoscopic index of severity (UCCIS) evaluates the state of the entire colonic mucosa in ulcerative colitis. However, no cut-off values of scores for predicting clinical relapse in patients with ulcerative colitis have been established. This study aimed to determine the cut-off values for predicting clinical relapse in patients with ulcerative colitis.

Methods
The endoscopic scores (sum of Mayo endoscopic subscores (S-MES) and UCCIS) of 157 patients with ulcerative colitis experiencing clinical remission and their subsequent clinical course were retrospectively reviewed. The optimal cut-off values for predicting relapse and relapse-free rates were analyzed by receiver operating characteristic analysis.

Results
Forty patients with ulcerative colitis experienced relapse within 24 months. The median UCCIS for these patients at the time of study enrollment was significantly higher than that for patients with clinical remission (P < 0.001). The cut-off value of the UCCIS for predicting relapse was 9.8. The relapse-free rate was significantly lower in patients with UCCIS ≥ 9.8 than in those with UCCIS < 9.8 (log-rank test P < 0.001). For patients who experienced relapse within 5 years, the optimal cut-off values for the UCCIS and S-MES were 10.2 and 1, respectively (P = 0.004).

Conclusions
The data from this study indicate that the USSIC is a more relevant score than the S-MES for predicting the time to relapse in patients with ulcerative colitis in remission.
Fixation stability and implant-associated complications in periacetabular osteotomy: a comparison of screw and K-wire fixation
Authors: Leopold Vincent Justus , Conrad Juana , Zahn Robert Karl , Hipfl Christian , Perka Carsten , Hardt Sebastian 
Published: August 2021

Abstract
Aims
The aim of this study was to compare the fixation stability and complications in patients undergoing periacetabular osteotomy (PAO) with either K-wire or screw fixation.

Patients and methods
We performed a retrospective study to analyze a consecutive series of patients who underwent PAO with either screw or K-wire fixation. Patients who were treated for acetabular retroversion or had previous surgery on the ipsilateral hip joint were excluded. 172 patients (191 hips: 99 K-wire/92 screw fixation) were included. The mean age at the time of PAO was 29.3 years (16–48) in the K-wire group and 27.3 (15–45) in the screw group and 83.9% were female. Clinical parameters including duration of surgery, minor complications (soft tissue irritation and implant migration) and major complications (implant failure and non-union) were evaluated. Radiological parameters including LCE, TA and FHEI were measured preoperatively, postoperatively and at 3-months follow-up.

Results
Duration of surgery was significantly reduced in the K-wire group with 88.2 min (53–202) compared to the screw group with 119.7 min (50–261) (p < 0.001). Soft tissue irritation occurred significantly more often in the K-wire group (72/99) than in the screw group (36/92) (p < 0.001). No group showed significantly more implant migration than the other. No major complications were observed in either group. Postoperative LCE, TA and FHEI were improved significantly in both groups for all parameters (p = < 0.0001). There was no significant difference for initial or final correction for the respective parameters between the two groups. Furthermore, no significant difference in loss of correction was observed between the two groups for the respective parameters.

Conclusion
K-wire fixation is a viable and safe option for fragment fixation in PAO with similar stability and complication rates as screw fixation. An advantage of the method is the significantly reduced operative time. A disadvantage is the significantly higher rate of implant-associated soft tissue irritation, necessitating implant removal.

Level of evidence
III, retrospective trial.
Awareness of obstetricians for long-term risks in women with a history of preeclampsia or HELLP syndrome
Authors: Palmrich Pilar , Binder Carina , Zeisler Harald , Kroyer Bettina , Pateisky Petra , Binder Julia 
Published: August 2021

Abstract
Purpose
Hypertensive disorders of pregnancy are still a leading cause of maternal and neonatal morbidity and mortality worldwide. Women with a history of preeclampsia have an increased risk for future cardiovascular and cerebrovascular disease, renal disease as well as diabetes mellitus. There is little knowledge on postpartum risk management. The aim of this study was to assess follow-up care for patients after pre-eclampsia or HELLP syndrome.

Methods
This questionnaire-based cross-sectional study aimed to evaluate the current recommendations of obstetricians in Austria regarding follow-up care, long-term risk counselling and risk of recurrence in future pregnancies after preeclampsia or HELLP syndrome. Data were collected using a survey, based on recommendations given by three substantial guidelines on hypertensive disorders of pregnancy, which was distributed via e-mail to 69 public obstetric departments in Austria. Each obstetric department was required to answer one questionnaire per local protocol.

Results
Our results revealed that of the 48 participating hospitals most obstetricians are aware of the importance of follow-up care for women after a pregnancy complicated by preeclampsia. Our data show that most physicians counselled patients about the future cardiovascular health risks associated with preeclampsia or HELLP syndrome (79.2%). Most obstetricians recommended lifestyle modification (77.1%) and continued blood pressure measurements (97.9%). All centers stated to counsel about the risk of recurrence (100%). However, counselling regarding follow-up care to exclude kidney damage (37.5%) and underlying diseases like thrombophilia (39.6%) were less prioritized.

Conclusions
We were able to show that counselling concerning the risk of long-term cardiovascular disease and risk of recurrence after a pregnancy complicated by preeclampsia or HELLP syndrome has been established in obstetric departments in public hospitals. Regarding the evaluation of underlying chronic diseases such as thrombophilia or renal disease, as well as counselling on the future risk of renal disease is still improvable according to our data. Further evaluation of follow-up care after hypertensive disorders of pregnancy in the outpatient and private sector and implementation of structured guidelines for follow-up, as well as screening for cardiovascular disease are necessary to ensure adequate risk management and to provide opportunities for prevention.
Risk of pain in the neck and shoulders and job change among hairdressers: a combined questionnaire and register-based Danish prospective cohort study
Authors: Aavang Petersen Jonathan , Brauer Charlotte , Thygesen Lau Caspar , Flachs Esben Meulengracht , Bach Lund Christina , Froelund Thomsen Jane 
Published: August 2021

Abstract
Objective
To investigate whether intensity of work as a hairdresser was associated with treatments for pain, and if musculoskeletal pain was associated with leaving the hairdressing trade.

Methods
We formed two cohorts of hairdressers covered in the PensionDanmark Health Scheme (PDHS). Cohort 1 consisted of 1304 active hairdressers in 2009. Self-reported weekly haircuts were used as work intensity measure and treatments for pain in the neck and shoulders in PDHS were used as outcome. We used a Cox regression model with robust sandwich estimates adjusted for age, sex, employment status and prior treatment < 1 year before July 2009. Cohort 2 consisted of all hairdressers ever covered in the PDHS from 2006 to 2016 (n = 11,162). Exposure were treatments in PDHS within the last year. Outcome was leaving the trade within the following year. Adjustments were made for sex, calendar-year and age in Cox regression models.

Results
The adjusted hazard ratio of treatments in PDHS compared to the lowest work intensity was 0.95 (95% CI 0.58–1.55) and 0.74 (0.43–1.29) for medium and highest intensity, respectively. The risk of leaving the trade was lower, HR 0.80 (0.72–0.90) among hairdressers with treatments in PDHS within the last year, mainly driven by hairdressers aged < 56 years.

Conclusion
We found no association between intensity of work as a hairdresser, measured as self-reported weekly haircuts, and treatments for pain in PDHS. Furthermore, we found a protective effect of treatments in the PDHS within the last year on risk of leaving the trade.
Kidney involvement and histological findings in two pediatric COVID-19 patients
Authors: Serafinelli Jessica , Mastrangelo Antonio , Morello William , Cerioni Valeria Fanny , Salim Adib , Nebuloni Manuela , Montini Giovanni 
Published: August 2021

Abstract
Background
Histological findings of kidney involvement have been rarely reported in pediatric patients with SARS-CoV-2 infection. Here, we describe clinical, laboratory, and histological findings of two pediatric cases with almost exclusive kidney involvement by SARS-CoV-2.

Results
A 10-year-old girl with IgA vasculitis nephritis underwent kidney biopsy, showing diffuse and segmental mesangial-proliferative glomerulonephritis, and steroid therapy was initiated. After the worsening of the clinical picture, including an atypical skin rash, she was diagnosed with SARS-CoV-2. The re-evaluation of initial biopsy showed cytoplasmatic blebs and virus-like particles in tubular cells at electron microscopy. Despite SARS-CoV-2 clearance and the intensification of immunosuppression, no improvement was observed. A second kidney biopsy showed a crescentic glomerulonephritis with sclerosis, while virus-like particles were no longer evident.
The second patient was a 12-year-old girl with a 3-week history of weakness and weight loss. Rhinitis was reported the month before. No medications were being taken. Blood and urine analysis revealed elevated serum creatinine, hypouricemia, low molecular weight proteinuria, and glycosuria. A high SARS-CoV-2-IgG titre was detected. Kidney biopsy showed acute tubular-interstitial nephritis. Steroid therapy was started with a complete resolution of kidney involvement.

Conclusion
We can speculate that in both cases SARS-CoV-2 played a major role as inflammatory trigger of the kidney damage. Therefore, we suggest investigating the potential kidney damage by SARS-CoV-2 in children. Moreover, SARS-CoV-2 can be included among infectious agents responsible for pediatric acute tubular interstitial nephritis.
A survey on the user acceptance of PV battery storage systems
Authors: Fett Daniel , Dehler-Holland Joris , Schmutz Markus 
Published: August 2021

AbstractThis study presents the results of an analysis of user acceptance of PV battery storage systems. A structural equation model is developed based on Davis’ technology acceptance model (TAM). It is expanded by integrating elements of Ajzen’s theory of planned behavior (TPB). The main factors influencing the acceptance of PV battery storage systems are evaluated and analyzed. Empirical findings indicate that survey participants’ acceptance of PV battery storage systems is mainly influenced by their behavioral beliefs, perceived knowledge about battery storage systems, perceived ease of use, and perceived usefulness of PV battery storage systems. The results indicate a high degree of acceptance for PV battery storage systems.
Adjoint Complement to the Universal Momentum Law of the Wall
Authors: Kühl Niklas , Müller Peter M. , Rung Thomas 
Published: August 2021

AbstractThe paper is devoted to an adjoint complement to the universal Law of the Wall (LoW) for fluid dynamic momentum boundary layers. The latter typically follows from a strongly simplified, unidirectional shear flow under a constant stress assumption. We first derive the adjoint companion of the simplified momentum equation, while distinguishing between two strategies. Using mixing-length arguments, we demonstrate that the frozen turbulence strategy and a LoW-consistent (differentiated) approach provide virtually the same adjoint momentum equations, that differ only in a single scalar coefficient controlling the inclination in the logarithmic region. Moreover, it is seen that an adjoint LoW can be derived which resembles its primal counterpart in many aspects. The strategy is also compatible with wall-function assumptions for prominent RANS-type two-equation turbulence models, which ground on the mixing-length hypothesis. As a direct consequence of the frequently employed assumption that all primal flow properties algebraically scale with the friction velocity, it is demonstrated that a simple algebraic expression provides a consistent closure of the adjoint momentum equation in the logarithmic layer. This algebraic adjoint closure might also serve as an approximation for more general adjoint flow optimization studies using standard one- or two-equation Boussinesq-viscosity models for the primal flow. Results obtained from the suggested algebraic closure are verified against the primal/adjoint LoW formulations for both, low- and high-Re settings. Applications included in this paper refer to two- and three-dimensional shape optimizations of internal and external engineering flows. Related results indicate that the proposed adjoint algebraic turbulence closure accelerates the optimization process and provides improved optima at no computational surplus in comparison to the frozen turbulence approach.
Fragility estimation for global building classes using analysis of the Cambridge earthquake damage database (CEQID)
Authors: Spence Robin , Martínez-Cuevas Sandra , Baker Hannah 
Published: August 2021

AbstractThis paper describes CEQID, a database of earthquake damage and casualty data assembled since the 1980s based on post-earthquake damage surveys conducted by a range of research groups. Following 2017–2019 updates, the database contains damage data for more than five million individual buildings in over 1000 survey locations following 79 severely damaging earthquakes worldwide. The building damage data for five broadly defined masonry and reinforced concrete building classes has been assembled and a uniform set of six damage levels assigned. Using estimated peak ground acceleration (PGA) for each survey location based on USGS Shakemap data, a set of lognormal fragility curves has been developed to estimate the probability of exceedance of each damage level for each class, and separate fragility curves for each of five geographical regions are presented. A revised set of fragility curves has also been prepared in which the bias in the curve resulting from the uncertainty in the ground motion parameter has been removed. The uncertainty in the fragility curves is evaluated and discussed and the curves are compared with those from other studies. A resistance index for each class of building is developed and cross-regional comparisons using this resistance index are presented.