bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Implementation of a Multipurpose Information System for Hematopoietic Stem-Cell Transplantation on the Basis of the Biomedical Research Integrated Domain Group Model
Authors: Bi Xia , Beadle Dania , Xu Alexander , Neff Joseph , DeGregorio Nicholas , Odeh Mouneer , McNair Christopher , Grosso Dolores , Porcu Pierluigi , Gergis Usama , Flomenberg Neal , Klumpp Thomas R. 
Published: November 2021

PURPOSE An important obstacle to cancer research is that nearly all academic cancer centers maintain substantial collections of highly duplicative, poorly quality-assured, nonintercommunicating, difficult-to-access data repositories. It is inherently clear that this state of affairs increases costs and reduces quality and productivity of both research and nonresearch activities. We hypothesized that designing and implementing a multipurpose cancer information system on the basis of the Biomedical Research Integrated Domain (BRIDG) model developed by the National Cancer Institute and its collaborators might lessen the duplication of effort inherent in capturing, quality-assuring, and accessing data located in multiple single-purpose systems, and thereby increases productivity while reducing costs. METHODS We designed and implemented a core data structure on the basis of the BRIDG model and incorporated multiple entities, attributes, and functionalities to support the multipurpose functionality of the system. We used the resultant model as a foundation upon which to design and implement modules for importing preexisting data, capturing data prospectively, quality-assuring data, exporting data to analytic files, and analyzing the quality-assured data to support multiple functionalities simultaneously. To our knowledge, our system, which we refer to as the Cancer Informatics Data System, is the first multipurpose, BRIDG-harmonized cancer research information system implemented at an academic cancer center. RESULTS We describe the BRIDG-harmonized system that simultaneously supports patient care, teaching, research, clinical decision making, administrative decision making, mandated volume-and-outcomes reporting, clinical quality assurance, data quality assurance, and many other functionalities. CONCLUSION Implementation of a highly quality-assured, multipurpose cancer information system on the basis of the BRIDG model at an academic center is feasible and can increase access to accurate data to support research integrity and productivity as well as nonresearch activities.
Developing, Implementing, and Validating a Social Toxicity Assessment Tool of Cancer
Authors: Jazieh Abdul-Rahman , Jradi Hoda , Da'ar Omar B. , Alkaiyat Mohammad , Zafar Yousuf , Alolayan Ashwaq 
Published: November 2021

PURPOSEThe social impact of cancer on patients and their family is well known. Yet, unlike with physical and financial toxicities, no validated tools are available to measure this impact. This study aimed at developing, validating, and implementing a novel social toxicity assessment tool for patients with cancer diagnosis (STAT-C).METHODSQuestions were generated through multiple steps including focus groups of patients, their families, and oncology care professionals. These steps along with relevant literature resulted in the development of an initial 20-item questionnaire. Content validity and relevance of the tool were assessed using Content Validity Index for individual items and Content Validity Index for the entire scale. Following expert examination, the constructed STAT-C tool consisted of 14 items grouped into three domains—social relations, social activities, and economic impact. Based on the total possible score for the survey in 150 patients for all the items, three levels of a socioeconomic toxicity were determined—severe social toxicity, mild social toxicity, and no social toxicity.RESULTSThe 14 items were marked as relevant, and the Content Validity Index for individual items ranged between 0.80 and 1.00. An overall average Content Validity Index for the entire scale of 0.87 showed high content validity of the constructed tool. Exploratory factor analysis revealed retention of 13 items of the constructed STAT-C Tool, which loaded across three factors that mapped groupings into measures of social relations, social activities, and economic impact domains.CONCLUSIONOur study revealed that STAT-C is a valid, reliable tool, and well captures and measures unique and pertinent social toxicity constructs for Arabic-speaking patients. The tool should enable oncology professionals to deliver better patient-centered care as a component of a comprehensive approach.
Archival Play
Authors: Carey Craig 
Published: November 2021

AbstractThis article offers a critical and personal reflection on the role of curiosity, fragments, and play in creating meaningful encounters with archives in the college classroom. Drawing on play theory, poetics, media studies, and pedagogical theory, the essay reimagines archival collections as formal and material playgrounds open to spontaneous experimentation. Through reflections on the finding aid, logistical media, Curious George, and other subjects, the essay finds in the archive an elemental play that can be harnessed to create a radically spontaneous pedagogy organized around student curiosity. By cultivating the curiosity inherent to archival play, teachers can actively shape the playful dividend that arrives when students enter the archive and begin to search, find, and discover meaningful patterns in the fragments of history.
Topical Issues of Radiopharmaceuticals Appliance in PET Studies
Authors: Khmelev A. 
Published: November 2021

CONTENT

Introduction
1. Requirements to radiopharmaceuticals
2. Factors affecting the biodistribution in organism
3. Uptake and localization mechanisms
4. Appliance in PET studies of biological processes and diagnostics
5. Aspects of regulation of radiopharmaceuticals circulation
Conclusion
Tert-butylhydroquinone attenuates osteoarthritis by protecting chondrocytes and inhibiting macrophage polarization
Authors: Zhang Hua , Li Jie , Xiang Xiaobing , Zhou Bengen , Zhao Changqing , Wei Qiushi , Sun Youqiang , Chen Jianfa , Lai Boyong , Luo Zequan , Li Aihua 
Published: November 2021

Aims Tert-butylhydroquinone (tBHQ) has been identified as an inhibitor of oxidative stress-induced injury and apoptosis in human neural stem cells. However, the role of tBHQ in osteoarthritis (OA) is unclear. This study was carried out to investigate the role of tBHQ in OA. Methods OA animal model was induced by destabilization of the medial meniscus (DMM). Different concentrations of tBHQ (25 and 50 mg/kg) were intraperitoneally injected in ten-week-old female mice. Chondrocytes were isolated from articular cartilage of mice and treated with 5 ng/ml lipopolysaccharide (LPS) or 10 ng/ml interleukin 1 beta (IL-1β) for 24 hours, and then treated with different concentrations of tBHQ (10, 20, and 40 μM) for 12 hours. The expression levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in blood were measured. The expression levels of interleukin 6 (IL-6), IL-1β, and tumour necrosis factor alpha (TNF-α) leptin in plasma were measured using enzyme-linked immunoabsorbent assay (ELISA) kits. The expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathway proteins, and macrophage repolarization-related markers, were detected by western blot. Results Tert-butylhydroquinone significantly attenuated cartilage destruction in DMM-induced mice in vivo. It demonstrated clear evidence of inhibiting IL-1β-induced chondrocyte apoptosis, inflammation, and differentiation defect in vitro. Meanwhile, tBHQ inhibited LPS-induced activation of NF-κB and MAPK signalling pathways, and also inhibited LPS-induced reactive oxygen species production and macrophages repolarization in vitro. Conclusion Taken together, tBHQ might be a potential therapeutic strategy for protecting against OA development. Cite this article: Bone Joint Res 2021;10(11):704–713.
Subcontracted racial capitalism: the interrelationship of race and production in meat processing plants
Authors: Piro Valeria , Sacchetto Devi 
Published: November 2021

The aim of this paper is to extend discussion on subcontracted labour by focussing on the labour process and on the role of race and racialization within it. The existing literature has so far analysed the factors that have encouraged employer decisions to outsource labour, together with its effects on labour conditions and on industrial relations. Missing, however, has been any detailed analysis of the role of race and racialization processes, pivotal elements in the facilitation of subcontracting thereby accelerating the worsening of labour conditions.
Based on qualitative empirical research on the meat industry in Northern Italy, this article highlights how the processes of outsourcing and racialization intersect to support the segmentation of labour within the workplace. In particular, we argue that, through contracting out work to racialized groups of migrant workers, outsourcing has been both facilitated and legitimized. Furthermore, the presence of in-plant contractors has fostered the implementation of racializing practices, which in turn have bolstered workforce fragmentation on racial lines.
Notwithstanding this, our findings show that race can be a factor in the mobilization of subcontracted migrant labour through the production of pragmatic (racial) solidarities. These informal ties are a key component in the development of the everyday struggles and alliances that emerge within grass roots worker organisations as well as beyond their boundaries through hybrid forms of collective organisation.
Low cross talk homogeneous seven-core five-LP mode fiber based on a high and low refractive index double ring
Authors: Wang Luyao , Li Shuguang , Meng Xiaojian , Guo Ying , Li Zenghui 
Published: November 2021

We propose a what we believe is a novel, to the best of our knowledge, high and low refractive index double-ring (HL-DR) structure in few-mode multicore fibers (FM-MCFs) to simultaneously suppress intercore cross talk (XT) and intermodal cross talk. The fabrication methods of HL-DR seven-core fiber are introduced. A series of intercore XT values are calculated by the average power coupling coefficient, which shows that the HL-DR structure has a great contribution to meet the intercore XT target of less than

−

30

d
B

/

100

k
m

in FM-MCFs. Intermodal XT is mainly measured by the effective refractive index difference (

Δ

n

e
f
f

) between modes, and the

Δ

n

e
f
f

between any two adjacent modes is larger than

2

×

1

0

−
3

. Other main fiber properties, including bending loss and dispersion, are also simulated by the finite-element method. The results imply that the bending loss can satisfy the requirement of five-LP mode operation over the C

+

L band. In addition, the dispersion comparison of

L
P

01

mode illustrates that the fiber dispersion performance is not significantly influenced by the addition of the HL-DR structure. Through numerical analyses, an optimal HL-DR seven-core five-LP mode fiber with low XT is obtained, and it has a relative core multiplicity factor (RCMF) of 62.17. The proposed structure targets the design and application of space division multiplexing fibers with high capacity and independent channels.
Parents’ perceived knowledge and beliefs on congenital malformations and their causes in the Amhara region, Ethiopia. A qualitative study
Authors: Taye Molla 
Published: November 2021

Introduction
Knowledge and beliefs of people on congenital malformations and their causes differ from society to society. As a result, there is a paucity of understanding community perceived knowledge and beliefs towards congenital malformations and their risk factors among children’s parents. Therefore, I sought to identify perceived knowledge and beliefs of parents on congenital malformations and their causes.

Methods
An in-depth discussion and interview were carried out on purposively selected forty participants (women and men) in the Amhara region, Ethiopia. The data were collected from June to July, 2015. Semi-structured guiding topics/questions were used during the discussions and in-depth interviews. Note and audio records were taken while the participants discussed the topics. After the discussions and in-depth interviews were completed, the transcripts were read repeatedly to understand the participant’s words, phrases, ideas, and concepts. Then notes were taken to combine pieces of similar transcripts. I have employed thematic framework analysis. The relevant transcripts were scrutinized, labeled and coded manually based on their relevance to the objective of the study. Then the coded transcripts were determined and categorized according to the type of thematic variables.

Results
The participants responded on three aspects of lived experience, perceived knowledge and beliefs on congenital malformations and their causes. Nearly half of the participants’ beliefs on the causes of congenital malformations were related to sin, contraceptive pills, un-prescribed drugs/medication use, and fertilizers (that is eating crops grown by using fertilizers). Almost all said that raising a child with a major congenital malformation was very difficult. About half of the participants’ belief on congenital malformations were traditional and resulted from poor awareness.

Conclusion
The findings of the present study highlight the challenges and impacts of congenital malformations on parents who had children with and without congenital malformation. Lived experience, perceived knowledge and beliefs of children parents on congenital malformation and their causes can be helpful information for designing preventive actions. Hence, planning a preventive strategy and providing health education on congenital malformations and their causes for children parents are very necessary.
Self-medication practices to prevent or manage COVID-19: A systematic review
Authors: Quincho-Lopez Alvaro , Benites-Ibarra Christeam A. , Hilario-Gomez Maryori M. , Quijano-Escate Renatta , Taype-Rondan Alvaro 
Published: November 2021

BackgroundPrevious studies have assessed the prevalence and characteristics of self-medication in COVID-19. However, no systematic review has summarized their findings.ObjectiveWe conducted a systematic review to assess the prevalence of self-medication to prevent or manage COVID-19.MethodsWe used different keywords and searched studies published in PubMed, Scopus, Web of Science, Embase, two preprint repositories, Google, and Google Scholar. We included studies that reported original data and assessed self-medication to prevent or manage COVID-19. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS) modified for cross-sectional studies.ResultsWe identified eight studies, all studies were cross-sectional, and only one detailed the question used to assess self-medication. The recall period was heterogeneous across studies. Of the eight studies, seven assessed self-medication without focusing on a specific symptom: four performed in the general population (self-medication prevalence ranged between <4% to 88.3%) and three in specific populations (range: 33.9% to 51.3%). In these seven studies, the most used medications varied widely, including antibiotics, chloroquine or hydroxychloroquine, acetaminophen, vitamins or supplements, ivermectin, and ibuprofen. The last study only assessed self-medication for fever due to COVID-19. Most studies had a risk of bias in the “representativeness of the sample” and “assessment of outcome” items of the NOS.ConclusionsStudies that assessed self-medication for COVID-19 found heterogeneous results regarding self-medication prevalence and medications used. More well-designed and adequately reported studies are warranted to assess this topic.
Dietary acrylamide and physical performance tests: A cross-sectional analysis
Authors: Veronese Nicola , Dominguez Ligia J. , Ragusa Saverio , Solimando Luisa , Smith Lee , Bolzetta Francesco , Maggi Stefania , Barbagallo Mario 
Published: November 2021

Background
Dietary acrylamide is found in certain foods, such as deep frying, baking and roasting, and is associated with higher inflammatory and oxidative stress parameters. The association between dietary acrylamide and physical performance has not yet been explored. The aim of the study was to investigate the relationship between dietary acrylamide intake and physical performance tests in a large cohort of North American individuals affected by knee osteoarthritis or at high risk for this condition.

Methods
Dietary acrylamide intake was obtained through a food frequency questionnaire and reported in quartiles and as an increase in deciles. Physical performance was explored using the 20-meter usual pace test, the 400-meter walking distance, and the chair stands time. The association between dietary acrylamide and physical performance tests was explored using linear regression analysis, adjusted for potential confounders.

Results
4,436 participants (2,578 women, mean age: 61.3) were enrolled. People in the highest quartile of dietary acrylamide reported significantly longer 20-meter walking (15.53±3.32 vs. 15.15±2.91 s), 400-meter walking (312±54 vs. 305±58 s) and chair stands (11.36±4.08 vs. 10.67±3.50 s) times than their counterparts in Q1. In adjusted linear regression analyses, each increase in one decile in dietary acrylamide was associated with a longer time in walking for 20 meters (beta = 0.032; 95%CI: 0.016–0.048; p = 0.04), 400 meters (beta = 0.048; 95%CI: 0.033–0.063; p = 0.002) and chair stands (beta = 0.016; 95%CI: 0.005–0.037; p = 0.04) times.

Conclusion
Higher dietary acrylamide intake was significantly associated with poor physical performance, also after accounting for potential confounders, suggesting a role for this food contaminant as a possible risk factor for sarcopenia.
Music and low-frequency vibrations for the treatment of chronic musculoskeletal pain in elderly: A pilot study
Authors: Eshuis Thom A. H. , Stuijt Peter J. C. , Timmerman Hans , Nielsen Peter Michael L. , Wolff André Paul , Soer Remko 
Published: November 2021

Background
Transcutaneous vagal nerve stimulation has analgesic potential and might be elicited by abdominally administered low-frequency vibrations. The objective was to study the safety and effect of a combination of music and abdominally administered low-frequency vibrations on pain intensity in elderly patients with chronic musculoskeletal pain.

Methods
This trial was an international multicenter, randomized controlled pilot study. Patients at age ≥ 65 years with musculoskeletal pain for ≥ 3 months and a daily pain score ≥ 4 out of 10 were recruited at three centers. They were randomized to receive either a combination of music and low-frequency (20–100 Hz) vibrations administered to the abdomen, or a combination with the same music but with higher frequency (200–300 Hz) vibrations administered to the abdomen. Low-frequency vibrations were expected to result in pain reduction measured with a numeric pain rating scale (NRS). Patients in both groups received eight treatments of the music combined with the vibrations in three weeks. Primary outcomes were safety (Serious Adverse Events) and pain intensity measured at baseline, after the last treatment and at six weeks follow-up. Multilevel linear model analyses were performed to study group and time effects.

Results
A total of 45 patients were analyzed according to intention-to-treat principle. After 344 treatments, 1 Adverse Event was found related to the intervention, while 13 Adverse Events were possibly related. A multilevel linear model showed that the interaction effect of group by time did not predict pain intensity (F[1, 45.93] = 0.002, p = 0.97) when comparing pain intensity at baseline, after the last treatment and at follow-up.

Conclusions
The combination of music and abdominally administered vibrations was found to be safe and well tolerated by the elderly patients. However, over time, neither the low-frequency treatment group nor the high-frequency treatment group provided clinically meaningful pain relief. There is no evidence that the low-frequency treatment elicited vagal nerve stimulation.

Trial registration
The trial was prospectively registered in the Netherlands Trial Register (NTR: NL7606) on 21-03-2019.
Critical reappraisal of neoadjuvant concurrent chemoradiotherapy for treatment of locally advanced colon cancer
Authors: Chen Yen-Cheng , Tsai Hsiang-Lin , Li Ching-Chun , Huang Ching-Wen , Chang Tsung-Kun , Su Wei-Chih , Chen Po-Jung , Yin Tzu-Chieh , Huang Chun-Ming , Wang Jaw-Yuan 
Published: November 2021

Background
Locally advanced colon cancer (LACC) is associated with surgical challenges during R0 resection, increased postoperative complications, and unfavorable treatment outcomes. Neoadjuvant concurrent chemoradiotherapy followed by surgical resection is an effective treatment strategy that can increase the complete surgical resection rate and improve the patient survival rate. This study investigated the efficacy and toxicity of concurrent chemoradiotherapy in patients with LACC as well as the prognosis and long-term clinical outcomes of these patients.

Materials
From January 2012 to July 2020, we retrospectively reviewed the real-world data of 75 patients with LACC who received neoadjuvant concurrent chemoradiotherapy. The chemotherapy regimen consisted of folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX). The following data were obtained from medical records: patients’ characteristics, pathologic results, toxicity, and long-term oncologic outcome.

Results
Of the 75 patients, 13 (17.3%) had pathologic complete responses. Hematologic adverse effects were the most common (grade 1 anemia: 80.0% and leukopenia: 82.7%). Conversely, grade 2 or 3 adverse effects were relatively uncommon (<10%). Pathologic N downstaging, ypT0, and pathologic complete responses were significant prognostic factors for patient survival. Multivariate analysis revealed that pathologic N downstaging was an independent predictor of patients’ overall survival (P = 0.019). The estimated 5-year overall and disease-free survival rates were 68.6% and 50.6%, and the medians of overall and disease-free survival periods were 72.3 and 58.7 months, respectively. Moreover, patients with pathologic complete responses had improved overall survival (P = 0.039) and an improved local recurrence control rate (P = 0.042) but an unfavorable distant metastasis control rate (P = 0.666) in the long-term follow-up.

Conclusion
The long-term oncologic outcome of patients with LACC following concurrent chemoradiotherapy is acceptable, and the adverse effects seem to be tolerable. Pathologic N downstaging was an independent prognostic factor for patients’ overall survival. However, a large prospective, randomized control study is required to confirm the current results.