bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary care-based models of care for osteoarthritis: a scoping review protocol
Authors: Cunningham Joice , Doyle Frank , Ryan Jennifer M. , Clyne Barbara , Cadogan Cathal , Cottrell Elizabeth , Smith Susan M. , French Helen P. 
Published: October 2021

Background: The burden of osteoarthritis (OA) to individuals and health systems is substantial and is expected to increase due to population ageing and rising prevalence of obesity and multimorbidity. Primary care-based models of care (MoCs) are being increasingly developed in response to this growing burden. However, these MoCs have yet to be formally reviewed. A MoC can be defined as an ‘evidence-informed strategy, framework or pathway that outlines the optimal manner in which condition-specific care should be delivered to consumers within a local health system’. Objective: To identify and describe the available research regarding the extent, nature and characteristics of MoCs for OA that have been developed or evaluated in primary care. Methods: A scoping review will be conducted in accordance with the Arksey and O’Malley scoping review framework and the PRISMA-ScR guidelines. Systematic literature searches of MEDLINE, EMBASE, CINAHL, PsychINFO, Web of Science and LILACs will be conducted from 2010 to present, aligning with publication dates of recent clinical guidelines. A structured iterative search of grey literature will be conducted. Full-text original quantitative or mixed method studies which describe the development or evaluation of MoCs for OA in primary care will be considered. Data will be charted and synthesised and a narrative synthesis will be conducted. Conclusions: This scoping review will provide a broad overview regarding the extent, nature and characteristics of the available literature on primary care based MoCs for OA. Findings will be used to identify gaps in the current evidence to identify areas for future research.
A national cross-sectional survey of constipation in patients attending cancer centres in Ireland
Authors: Ryan Karen , Johnston Bridget M. , McAleer Clare , O'Connor Laserina , Larkin Philip 
Published: October 2021

Background: The prevalence of constipation in patients with cancer is estimated at 50-90%. It is often associated with pain, anorexia, nausea and vomiting and impacts negatively on quality of life. Despite its common occurrence, it is often poorly recognised and treated by healthcare professionals. Methods: A national cross-sectional survey was conducted in Ireland to describe constipation prevalence and severity in patients attending cancer centres and to evaluate management efficacy. In-patients or patients attending day oncology wards in any of the country’s eight designated cancer centres were eligible to participate. Participants were shown the Bristol Stool Chart and answered questions regarding stool appearance and sensation of incomplete defecation; they completed the Constipation Assessment Scale. Data on pain character and intensity, opioid use, and prescribed and over-the-counter laxative use were collected. Data were summarised using descriptive statistics. Significance of variations for continuous data were determined using t-tests. Conditional ordered logistic regression was undertaken to determine factors associated with constipation. Results: The dataset comprised 491 patients. 24.8% had been reviewed by specialist palliative care; 14.5% by the anaesthetic pain team. In total, 42.2% of respondents were taking step 2 or step 3 opioids. Constipation prevalence was 67.6%; 19.4% of patients had Constipation Assessment Scale scores indicating severe constipation. A total of 46% of the respondents were not taking any laxatives. Of those who were taking laxatives, 54.8% reported constipation symptoms. While opioid use was strongly associated with participants reporting higher scores, this association was not seen in those patients receiving specialist palliative care. Conclusions: Constipation remains a clinical problem in Irish cancer centres. Despite increased opioid use, patients receiving specialist palliative care were more likely to take laxatives and reported less constipation. Specialist palliative care practice should be studied in order to identify what are the transferable ‘ingredients’ of effective constipation management.
Concordance between PCR-based extraction-free saliva and nasopharyngeal swabs for SARS-CoV-2 testing
Authors: De Santi Chiara , Jacob Benson , Kroich Patricia , Doyle Sean , Ward Rebecca , Li Brian , Donnelly Owain , Dykes Amy , Neelakant Trisha , Neary David , McGuinness Ross , Cafferkey Jacqueline , Ryan Kieran , Quadu Veronica , McGrogan Killian , Garcia Leon Alejandro , Mallon Patrick , Fitzpatrick Fidelma , Humphreys Hilary , De Barra Eoghan , Kerrigan Steve W. , Cavalleri Gianpiero L. 
Published: October 2021

Introduction: Saliva represents a less invasive alternative to nasopharyngeal swab (NPS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. SalivaDirect is a nucleic acid extraction-free method for detecting SARS-CoV2 in saliva specimens. Studies evaluating the concordance of gold standard NPS and newly developed SalivaDirect protocols are limited. The aim of our study was to assess SalivaDirect as an alternative method for COVID-19 testing. Methods: Matching NPS and saliva samples were analysed from a cohort of symptomatic (n=127) and asymptomatic (n=181) participants recruited from hospital and university settings, respectively. RNA was extracted from NPS while saliva samples were subjected to the SalivaDirect protocol before RT-qPCR analysis. The presence of SARS-Cov-2 was assessed using RdRp and N1 gene targets in NPS and saliva, respectively. Results: Overall we observed 94.3% sensitivity (95% CI 87.2-97.5%), and 95.9% specificity (95% CI 92.4-97.8%) in saliva when compared to matching NPS samples. Analysis of concordance demonstrated 95.5% accuracy overall for the saliva test relative to NPS, and a very high level of agreement (κ coefficient = 0.889, 95% CI 0.833–0.946) between the two sets of specimens. Fourteen of 308 samples were discordant, all from symptomatic patients. Ct values were >30 in 13/14 and >35 in 6/14 samples. No significant difference was found in the Ct values of matching NPS and saliva sample (p=0.860). A highly significant correlation (r = 0.475, p<0.0001) was also found between the Ct values of the concordant positive saliva and NPS specimens. Conclusions: Use of saliva processed according to the SalivaDirect protocol represents a valid method to detect SARS-CoV-2. Accurate and less invasive saliva screening is an attractive alternative to current testing methods based on NPS and would afford greater capacity to test asymptomatic populations especially in the context of frequent testing.
BUILDING CHARACTER OF HARDINESS THROUGH RELIGIOUSITY AND LOCAL WISDOM FOR MERCHANT MARINE CADET IN ACEH, INDONESIA
Authors: Subiyantoro Subiyantoro , Budiyanto Mangun , Riyanto Budi , Surahman Buyung 
Published: October 2021

This study aims to describe the model of character building of prospective marine transportation cadets in Malahayati Merchant Marine Polytechnic, Aceh, Indonesia. The research method used in this study was a qualitative method using a phenomenological research design. Through participatory action research, in-depth interviews, observation, and documentation, the data were found, which Miles and Huberman’s model used as data analysis. The data analysis process consisted of data reduction, data display, drawing conclusion/verification. The research result showed that character educational implementation of Merchant Marine Education in Aceh was conducted through (1) the instruction method, education, suggestion, persuasion, trusting, punishment, guidance and counseling, Habituation, group discussion, and organizational activities. The method implementation adjusted to the activities and educational cadet level starting from prospective cadet to senior cadet. (2) Method implementation intervention conducted through the hidden curriculum like moral knowing, moral feeling, moral action, and religiosity that manifests in five diversity dimensions: religious belief, religious practice, religious feeling, religious knowledge, and religious effects. (3) Attitude nurture implementation conducted through local wisdom habituation that includes exemplary figures of leaders/coach/trainers/senior cadets, behavioral standards, and reflection studies. (4) Religious character educational implementation bears a resilient cadet profile who is smart, professional, skilled, and good. This research finding recommended the importance of religiosity and local wisdom in building the character of Hardiness.
Consumer Acceptance and Willingness to Pay for Prebiotic Kuini Juice in Malaysia
Authors: Kasron Norzalila , Baharudin Siti 'Aisyah , Saari Saiful Bahri , Mat Azmin Mohd Nur Hafiz , Saari Nor Azlina 
Published: October 2021

Changing consumers' lifestyles and food consumption patterns provide an excellent opportunity to develop the prebiotics market in Malaysia. Therefore, Malaysia is trying to improve products based on local ingredients such as kuini juice developed by the Malaysian Agricultural Research and Development Institute (MARDI). The high fibre content found in kuini makes it suitable to be used as one of the essential ingredients in prebiotic drinks. This research attempted to analyse consumer acceptance and willingness to pay for prebiotic kuini juice. A survey was conducted in Peninsular Malaysia, where 400 respondents were interviewed using a structured questionnaire. Exploratory factor analysis, Kaiser-Meyer-Olkin test and Bartlett's Test of Sphericity were utilised for objective analysis 1, while the Contingent Valuation Method was utilised for objective analysis 2. The result showed that 73% of respondents had taken prebiotic juice in the past. The tendency to choose prebiotic kuini juice by MARDI was 52% compared to existing products in the market. Significant findings determined consumers' preference factors, including product marketing and promotion, which influenced the purchasing of prebiotic kuini juice. The willingness to pay by respondents was lower at RM4.10/300ml bottle than the actual price bid at RM5.70/300ml bottle. As consumer awareness of health increases, it was an opportunity for the health food industry to expand the functional food market. However, some improvements should be adjusted to ensure prebiotic kuini juice can compete with other similar products in the market. Government support is needed to encourage indigenous fruits cultivation and to produce value-added products.
Spatial resolution enhancement of coherent Doppler wind lidar using differential correlation pair technique
Authors: Zhang Yunpeng , Wu Yunbin , Xia Haiyun 
Published: October 2021

A high spatial resolution coherent Doppler wind lidar (CDWL) incorporating the differential correlation pair (DCP) technique is proposed and demonstrated. By employing pulse pair with appropriate window functions, the spatial resolution can be enhanced, as the common parts of the correlation pair can be eliminated in the differential data processing. The performance of the new method is validated in the comparison experiment with the CDWLs adopting conventional schemes. Under a given peak power, the DCP technique provides higher wind velocity accuracy compared with a conventional pulsed CDWL where the laser spectral broadening caused by short pulses can be avoided and the carrier-to-noise ratio is improved. At a laser peak power of 250 W, with a spatial and temporal resolution of 3.3 m and 1 s, continuous radial wind profiling over 700 m is realized with a maximum error of 0.1 m/s.
Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients
Authors: Li Ying , Ju Shuai , Li Xin , Zhou Yan Li , Qiang Jin Wei 
Published: October 2021

ObjectiveTo construct an MR-radiomics nomogram to predict minimal hepatic encephalopathy (MHE) in patients with chronic hepatic schistosomiasis (CHS).MethodsFrom July 2017 to July 2020, 236 CHS patients with non-HE (n = 140) and MHE (n = 96) were retrospective collected and randomly divided into training group and testing group. Radiomics features were extracted from substantia nigra-striatum system of a brain diffusion weighted images (DWI) and combined with clinical predictors to build a radiomics nomogram for predicting MHE in CHS patients. The ROC curve was used to evaluate the predicting performance in training group and testing group. The clinical decisive curve (CDC) was used to assess the clinical net benefit of using radiomics nomogram in predicting MHE.ResultsLow seralbumin (P < 0.05), low platelet count (P < 0.05) and high plasma ammonia (P < 0.05) was the significant clinical predictors for MHE in CHS patients. The AUC, specificity and sensitivity of the radiomics nomogram were 0.89, 0.90 and 0.86 in the training group, and were 0.83, 0.85 and 0.75 in the training group. The CDC analysis showed clinical net benefits for the radiomics nomogram in predicting MHE.ConclusionsThe radiomics nomogram combining DWI radiomics features and clinical predictors could be useful tool to predict MHE in CHS patients.
Association of abnormal pulmonary vasculature on CT scan for COVID-19 infection with decreased diffusion capacity in follow up: A retrospective cohort study
Authors: Salerno Daniel , Oriaku Ifeoma , Darnell Melinda , Lanclus Maarten , De Backer Jan , Lavon Ben , Gupta Rohit , Jaffe Fredric , Vega Sanchez Maria Elena , Kim Victor ,   on behalf of the Temple University Covid-19 Research Group
Published: October 2021

Background
Coronavirus Disease 2019 (COVID-19) is a respiratory viral illness causing pneumonia and systemic disease. Abnormalities in pulmonary function tests (PFT) after COVID-19 infection have been described. The determinants of these abnormalities are unclear. We hypothesized that inflammatory biomarkers and CT scan parameters at the time of infection would be associated with abnormal gas transfer at short term follow-up.

Methods
We retrospectively studied subjects who were hospitalized for COVID-19 pneumonia and discharged. Serum inflammatory biomarkers, CT scan and clinical characteristics were assessed. CT images were evaluated by Functional Respiratory Imaging with automated tissue segmentation algorithms of the lungs and pulmonary vasculature. Volumes of the pulmonary vessels that were ≤5mm (BV5), 5-10mm (BV5_10), and ≥10mm (BV10) in cross sectional area were analyzed. Also the amount of opacification on CT (ground glass opacities). PFT were performed 2–3 months after discharge. The diffusion capacity of carbon monoxide (DLCO) was obtained. We divided subjects into those with a DLCO <80% predicted (Low DLCO) and those with a DLCO ≥80% predicted (Normal DLCO).

Results
38 subjects were included in our cohort. 31 out of 38 (81.6%) subjects had a DLCO<80% predicted. The groups were similar in terms of demographics, body mass index, comorbidities, and smoking status. Hemoglobin, inflammatory biomarkers, spirometry and lung volumes were similar between groups. CT opacification and BV5 were not different between groups, but both Low and Normal DLCO groups had lower BV5 measures compared to healthy controls. BV5_10 and BV10 measures were higher in the Low DLCO group compared to the normal DLCO group. Both BV5_10 and BV10 in the Low DLCO group were greater compared to healthy controls. BV5_10 was independently associated with DLCO<80% in multivariable logistic regression (OR 1.29, 95% CI 1.01, 1.64). BV10 negatively correlated with DLCO% predicted (r = -0.343, p = 0.035).

Conclusions
Abnormalities in pulmonary vascular volumes at the time of hospitalization are independently associated with a low DLCO at follow-up. There was no relationship between inflammatory biomarkers during hospitalization and DLCO. Pulmonary vascular abnormalities during hospitalization for COVID-19 may serve as a biomarker for abnormal gas transfer after COVID-19 pneumonia.
Ventricular outflow tract obstruction: An in-silico model to relate the obstruction to hemodynamic quantities in cardiac paediatric patients
Authors: Comunale Giulia , Padalino Massimo , Maiorana Carmelo , Di Salvo Giovanni , Susin Francesca M. 
Published: October 2021

Background
Right (R) or left (L) ventricular outflow tract (VOT) obstruction can be either a dynamic phenomenon or a congenital anatomic lesion, which requires a prompt and optimal timing of treatment to avoid a pathological ventricular remodelling.

Objective
To develop a simple and reliable numerical tool able to relate the R/L obstruction size with the pressure gradient and the cardiac output. To provide indication of the obstruction severity and be of help in the clinical management of patients and designing the surgical treatment for obstruction mitigation.

Methods
Blood flow across the obstruction is described according to the classical theory of one-dimensional flow, with the obstruction uniquely characterized by its size. Hemodynamics of complete circulation is simulated according to the lumped parameter approach. The case of a 2 years-old baby is reproduced, with the occlusion placed in either the R/ or the L/VOT. Conditions from wide open to almost complete obstruction are reproduced.

Results
Both R/LVOT obstruction in the in-silico model resulted in an increased pressure gradient and a decreased cardiac output, proportional to the severity of the VOT obstruction and dependent on the R/L location of the obstruction itself, as it is clinically observed.

Conclusion
The in-silico model of ventricular obstruction which simulates pressure gradient and/or cardiac output agrees with clinical data, and is a first step towards the creation of a tool that can support the clinical management of patients from diagnosis to surgical treatments.
Why we habitually engage in null-hypothesis significance testing: A qualitative study
Authors: Stunt Jonah , van Grootel Leonie , Bouter Lex , Trafimow David , Hoekstra Trynke , de Boer Michiel 
Published: October 2021

Background
Null Hypothesis Significance Testing (NHST) is the most familiar statistical procedure for making inferences about population effects. Important problems associated with this method have been addressed and various alternatives that overcome these problems have been developed. Despite its many well-documented drawbacks, NHST remains the prevailing method for drawing conclusions from data. Reasons for this have been insufficiently investigated. Therefore, the aim of our study was to explore the perceived barriers and facilitators related to the use of NHST and alternative statistical procedures among relevant stakeholders in the scientific system.

Methods
Individual semi-structured interviews and focus groups were conducted with junior and senior researchers, lecturers in statistics, editors of scientific journals and program leaders of funding agencies. During the focus groups, important themes that emerged from the interviews were discussed. Data analysis was performed using the constant comparison method, allowing emerging (sub)themes to be fully explored. A theory substantiating the prevailing use of NHST was developed based on the main themes and subthemes we identified.

Results
Twenty-nine interviews and six focus groups were conducted. Several interrelated facilitators and barriers associated with the use of NHST and alternative statistical procedures were identified. These factors were subsumed under three main themes: the scientific climate, scientific duty, and reactivity. As a result of the factors, most participants feel dependent in their actions upon others, have become reactive, and await action and initiatives from others. This may explain why NHST is still the standard and ubiquitously used by almost everyone involved.

Conclusion
Our findings demonstrate how perceived barriers to shift away from NHST set a high threshold for actual behavioral change and create a circle of interdependency between stakeholders. By taking small steps it should be possible to decrease the scientific community’s strong dependence on NHST and p-values.
Determinants of quality of life in women immediately following the completion of primary treatment of breast cancer: A cross-sectional study
Authors: Park Jin-Hee , Jung Yong Sik , Kim Ji Young , Bae Sun Hyoung 
Published: October 2021

BackgroundsMany breast cancer patients experience significant distress immediately following the completion of primary treatment. Women who report low levels of quality of life (QOL) early in this phase of transitional survivorship tend to experience diminished long-term adjustment. However, since most of the prior studies on survivors were conducted on patients at various times, studies on QOL of women during the end of primary treatment have been insufficient. This study aimed to identify determinants of QOL in women with breast cancer immediately following the completion of treatment.MethodsA cross-sectional study was conducted on 140 disease-free breast cancer patients who had completed therapy in the past 1 month at university hospitals. Functional Assessment of Cancer Therapy-Breast (FACT-B), Memorial Symptom Assessment Scale-Short Form (MSAS-SF), Self-Efficacy Scale for Self-Management of Breast Cancer (SESSM-B), and Interpersonal Support Evaluation List-12 (ISEL-12) scales were used to assess predictors and QOL. The data were analyzed using the Pearson correlation, t-test, ANOVA, and hierarchical multiple regression.ResultsThe mean score of QOL for breast cancer survivors was 97.23 (±20.01). Chemotherapy and perceived economic status were significantly associated with QOL in terms of sociodemographic and disease/treatment-related characteristics. Physical and psychological symptoms and social support had a significant association with QOL. The regression analyses showed that physical and psychological symptoms and belonging support were statistically significant in predicting the QOL of breast cancer survivors.ConclusionsThe variables of symptom experience and social support must be acknowledged when improving women’s QOL immediately after their completion of primary breast cancer treatment. Greater focus on the reduction of symptom distress and increasing a sense of belonging could improve QOL among breast cancer survivors.