bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing the sensitivity of surface‐enhanced Raman scattering detection for s‐triazine pesticides by taking advantage of interactions with soil humic substances
Authors: Rubira Rafael J. G. , Camacho Sabrina A. , Constantino Carlos J. L. , Sanchez‐Cortes Santiago 
Published: October 2021

AbstractSurface‐enhanced Raman scattering (SERS) is a technique which has been well explored for detecting contaminating substances, such as pesticides. Of particular interest has been the use of SERS for quantifying trace levels of the s‐triazine compounds, unraveling the adsorption mechanisms on metallic nanoparticles. Herein, we applied silver nanoparticles (AgNP) as SERS substrates for detecting commercial samples of the pesticides prometryn (PRM) and atrazine (ATZ) and their purified samples in the presence of soil humic substances (SHS). The degrading effect of SHS was assessed through the similarities between the SERS spectra of the purchased pesticides and purified pesticides in the presence of SHS. We also evaluated the mechanisms of interaction between the purified pesticide molecules and SHS. Strong interactions of the amino groups (s‐triazine molecules) with the oxygenated groups (SHS) were confirmed via SERS spectra. Such interaction, which is favorable for purified pesticides, allowed to increase the sensitivity of SERS detection, reaching low limits of detection (LOD): 5.5 ppb and 4.0 ppb for unpurified PRM and ATZ (as purchased), respectively, against 1.3 ppb and 21 ppt for purified PRM and ATZ in the presence of the SHS, respectively.
Characterization of a recombinant 10‐linoleic acid hydratase from Lactiplantibacillus plantarumZS2058 and biosynthesis of 10‐ hydroxy‐cis‐12‐octadecenoic acid
Authors: Peng Shuyue , Zhang Yanzhen , Guo Qianwan , Wang Chenchen , Gaenzle Michael G , Zhao Meng 
Published: October 2021

AbstractBACKGROUND10‐Hydroxy‐cis‐12‐octadecenoic acid (10‐HOE, 10‐OH C18:1), an emerging functional fatty acid, has anti‐fungal and anti‐inflammatory effects. 10‐HOE is synthesized by bacterial 10‐linoleic acid hydratase (10‐LHT) with linoleic acid as the substate. However, the characterization of 10‐LHT and its targeted synthesis of 10‐HOE have been rarely reported. In this study, the recombinant 10‐LHT from Lactiplantibacillus plantarum ZS2058 was characterized, and the biocatalysis of 10‐HOE using crude enzyme was optimized.RESULTSThe recombinant 10‐LHT catalyzed the conversion of linoleic acid (C18:2) to 10‐HOE as identified using gas chromatography‐mass spectrometry (GC–MS). It showed a molecular weight of about 70 kDa on sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS‐PAGE), and was a flavin adenine dinucleotide (FAD)‐dependent enzyme. The activity of 10‐LHT was optimal at pH 6.5 and 25 °C, and it was pH‐stable but thermo‐sensitive. The optimal condition for the 10‐HOE biosynthesis using crude enzyme was 5 g L−1 linoleic acid (C18:2), 148.0 U mL−1 10‐LHT, 0.05 mmol L−1 FAD, 2% methanol and 100 mmol L−1 sodium chloride at 25 °C and pH 6.5. A conversion yield of 47.8 ± 1.5% and the corresponding 10‐HOE concentration of 2.4 ± 0.1 g L−1 were achieved at 48 h under the optimal reaction conditions.CONCLUSIONThis work achieved the highest conversion yield of 10‐HOE with the highest substrate concentration, and provides some useful information for the industrial production of 10‐HOE. © 2021 Society of Chemical Industry.
Redefining Success After Liver Transplantation: From Mortality Toward Function and Fulfillment
Authors: Serper Marina , Asrani Sumeet , VanWagner Lisa , Reese Peter P. , Kim Minjee , Wolf Michael S. 
Published: October 2021

Liver transplantation (LT), the only cure for end‐stage liver disease, is a lifesaving, costly, and limited resource. LT recipients (LTRs) are aging with an increasing burden of medical comorbidities. Patient and graft survival rates exceed 70% at 5 years; however, patient‐centered health outcomes beyond survival have received relatively little attention. LTRs must have strong self‐management skills to navigate health systems, adhere to clinical monitoring, and take complex, multidrug regimens. All of these tasks require formidable cognitive abilities for active learning and problem solving. Yet, LTRs are at higher risk for impaired cognition as a result of the high prevalence of pretransplant hepatic encephalopathy, multiple chronic conditions, alcohol use, physical frailty, sarcopenia, and older age. Cognitive impairment after transplant may persist and has been causally linked to poor self‐management skills, worse physical function, and inferior health outcomes in other health care settings, yet its impact after LT is largely unknown. There is a need to study potentially modifiable, posttransplant targets including caregiver support, physical activity, sleep, and treatment adherence to inform future health system responses to promote the long‐term health and well‐being of LTRs. Prospective, longitudinal data collection that encompasses key sociodemographic, cognitive–behavioral, psychosocial, and medical factors is needed to improve risk prediction and better inform patient and caregiver expectations. Interventions with proactive monitoring, reducing medical complexity, and improved care coordination can be tailored to optimize posttransplant care. We propose a research agenda focused on understudied, potentially modifiable risk factors to improve the long‐term health of LTRs. Our conceptual model accounts for cognitive function, caregiver and patient self‐management skills, health behaviors, and patient‐centered outcomes beyond mortality. We propose actionable health‐system, patient, and caregiver‐directed interventions to fill knowledge gaps and improve outcomes.
Osteogenic Capability of Vaterite‐Coated Nonwoven Polycaprolactone Scaffolds for In Vivo Bone Tissue Regeneration
Authors: Saveleva Mariia S. , Ivanov Alexey N. , Chibrikova Julia A. , Abalymov Anatolii A. , Surmeneva Maria A. , Surmenev Roman A. , Parakhonskiy Bogdan V. , Lomova Maria V. , Skirtach Andre G. , Norkin Igor A. 
Published: October 2021

AbstractIn current orthopedic practice, bone implants used to‐date often exhibit poor osteointegration, impaired osteogenesis, and, eventually, implant failure. Actively pursued strategies for tissue engineering could overcome these shortcomings by developing new hybrid materials with bioinspired structure and enhanced regenerative potential. In this study, the osteogenic and therapeutic potential of bioactive vaterite is investigated as a functional component of a fibrous polymeric scaffold for bone regeneration. Hybrid two‐layered polycaprolactone scaffolds coated with vaterite (PCL/CaCO3) are studied during their 28‐days implantation period in a rat femur defect. After this period, the study of tissue formation in the defected area is performed by the histological study of femur cross‐sections. Immobilization of alkaline phosphatase (ALP) into PCL/CaCO3 scaffolds accelerates new bone tissue formation and defect repair. PCL/CaCO3 and PCL/CaCO3/ALP scaffolds reveal 37.3% and 62.9% areas, respectively, filled with newly formed bone tissue in cross‐sections compared to unmineralized PCL scaffold (17.5%). Bone turnover markers are monitored on the 7th and 28th days after implantation and reveal an increase of osteocalcin level for both PCL/CaCO3 and PCL/CaCO3/ALP compared with PCL indicating the activation of osteogenesis. These findings indicate that vaterite, as an osteoconductive component of polymeric scaffolds, promotes osteogenesis, supports angiogenesis, and facilitates bone defect repair.
Effect of the chemical structure of a tetradentate equatorial ligand on the spin‐crossover properties of the Fe (III) complexes chain structures: Electron paramagnetic resonance study
Authors: Turanova Olga A. , Frolova Elena N. , Gafiyatullin Linar G. , Bazan Leah V. , Turanov Alexander N. , Ovchinnikov Igor V. 
Published: October 2021

AbstractThe effect of the chemical structure of the equatorial ligand on the spin state of the Fe (III) ion in a series of 1‐D chain complexes of the general formula [Fe(L)(tvp)]BPh4·nCH3OH, where L = dianions of Schiff base containing a different number of aromatic groups: N,N′‐ethylenebis (salicylaldimine) (salen) 1, N,N′‐ethylenebis (acetylacetone)2,2′‐imine (acen) 2, N,N′‐ethylenebis (benzoylacetylacetone)2,2′‐imine (bzacen) 3, and tvp = 1,2‐di(4‐pyridyl)ethylene, was studied by ultraviolet–visible (UV–vis) and electron paramagnetic resonance (EPR) methods. The values of exchange interactions, thermodynamic parameters of spin‐crossover, and electronic structure features of the Fe (III) complexes were estimated from the EPR data. The substitution of a fragment of the equatorial ligand L in the series salen–acen–bzacen changes the local symmetry of the complex in the 1‐D chain, thereby affecting the spin variable properties.
Video‐urodynamic characteristics of lower urinary tract dysfunctions in patients with chronic brain disorders
Authors: Chiang Ching‐Hsiang , Chen Sen‐Fu , Kuo Hann‐Chorng 
Published: October 2021

AbstractAimsLower urinary tract dysfunction (LUTD) is common in patients with chronic brain disorders. This study investigated the video‐urodynamic study (VUDS) findings of LUTD in patients with chronic brain disorders, including cerebrovascular accident (CVA), Parkinson's disease (PD), and early dementia.MethodsA total of 169 patients with a history of chronic brain disorders, including 84 with CVA, 55 with PD, and 30 with early dementia were enrolled. All patients had a comprehensive chart review, including brain disorder subtype, the period from diagnosis to VUDS, the VUDS parameters, and final LUTD.ResultsThe mean age of patients was 69.2 ± 10.5 years, and the interval from brain insult to VUDS was 61.3 ± 49.7 months. Urodynamic detrusor overactivity (DO) was noted in 73.4% of patients, detrusor underactivity in 10.1%, and detrusor overactivity with detrusor underactivity in 16.6%. Bladder outlet obstruction (BOO) was noted in 60.9% of patients, including bladder neck dysfunction in 21.3%, urethral sphincter dysfunction in 42%, and prostatic obstruction in 10.1% of male patients. Urethral sphincter dysfunction was noted in 60% of patients with PD, 32.1% with CVA, and 36.7% with dementia (p = 0.004). A low mean maximum flow rate increased post‐void residual volume, and poor voiding efficiency was common in these patients, without significant differences among the subgroups.ConclusionsReal‐world VUDSs revealed that patients with chronic brain disorders not only had a high prevalence of DO but also impaired bladder contractility and a high rate of BOO at the level above the bladder neck and urethral sphincter.
Body composition of patients with neuroblastoma using computed tomography
Authors: IJpma Irene , Lequin Maarten H. , Nievelstein Rutger A. J. , Fiocco Marta , Tissing Wim J. E. 
Published: October 2021

AbstractBackgroundComputed tomography (CT) is often used to investigate muscle and fat mass in adult patients with cancer. However, this method has rarely been used in the pediatric cancer population. The present retrospective study aimed to investigate changes in body composition using CT during treatment in children with neuroblastoma.ProcedureCT images of 29 patients with high‐risk neuroblastoma were retrospectively analyzed at diagnosis and longitudinally during treatment. The cross‐sectional area of skeletal muscle, intermuscular adipose tissue (IMAT), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) and skeletal muscle density at the level of the third lumbar vertebra were examined. To correct for height, cross‐sectional areas were divided by height in meters squared. A linear mixed model was estimated to investigate changes in body composition over time.ResultsA small increase in skeletal muscle (p = .029), skeletal muscle density (p = .002), and IMAT (p < .001) was found. Furthermore, a rapid increase in VAT (p < .001) and SAT (p = .001) was seen early during treatment with the highest volumes after six cycles of chemotherapy.ConclusionsCT scans obtained during standard care provide insight into the direction and timing of changes in skeletal muscle and different types of adipose tissue in childhood cancer patients. Future research is needed regarding the consequences of the rapid increase of VAT and SAT early during treatment.
Kaposiform hemangioendothelioma of the bone in children and adolescents
Authors: Kuo Christopher , Warren Mikako , Malvar Jemily , Miller Joseph M. , Shah Rachana , Navid Fariba , Luu Minnelly , Anselmo Dean M. , Mascarenhas Leo 
Published: October 2021

AbstractKaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that mainly occurs during infancy or early childhood. Approximately 70% of cases are complicated by Kasabach‐Merritt phenomenon. Although osseous extension of the primary lesion is relatively common, primary bone involvement by KHE is rare. Given the paucity of literature on primary KHE of the bone, we report a case series of primary KHE of the bone treated at our institution and describe the clinical presentation, radiologic and pathologic findings, management and outcomes.
Physical activity and exercise in the management of type 2 diabetes: where to start?
Authors: Harrington Deirdre , Henson Joe 
Published: October 2021

Abstract
Physical activity is a fundamental therapeutic aid in the management of type 2 diabetes (T2D). Regular engagement elicits a plethora of adaptations which leads to improvements in clinical outcomes, such as HbA1c, lipids and blood pressure as well as whole body health and physical function benefits. Those with T2D are encouraged to engage in a minimum of 150 minutes/week of moderate‐intensity physical activity (or 75 minutes/week of vigorous activity). Current recommendations also suggest that this should be supplemented with two‐to‐three resistance, flexibility and/or balance training sessions/week. The latter is particularly encouraged for older individuals or those with limited mobility/poor physical function. Those with T2D are also encouraged to break up prolonged bouts of sitting.However, a large proportion of the general population do not meet current physical activity guidelines, with the figure even lower in those with T2D. Getting started and sustaining a physically active lifestyle is challenging. Therefore, this article aims to provide health care professionals with the information required to tailor guidance to individuals with T2D by: presenting an overview of current guidelines, terminology and benefits; discussing the risk of adverse events; precautions when exercising with complications; practical options for getting started and how to tailor advice in primary care.Where appropriate, individual preferences and motivations should inform decision making regarding exercise modality in order to maximise compliance. That said, the overarching message is that any physical activity is better that none, but more is better especially when combined with a reduction in sitting. Copyright © 2021 John Wiley & Sons.
Half and full solar cell efficiency binning by deep learning on electroluminescence images
Authors: Buratti Yoann , Sowmya Arcot , Evans Rhett , Trupke Thorsten , Hameiri Ziv 
Published: October 2021

AbstractEnd‐of‐line characterization of solar cells is necessary to filter out defective cells and bin cells to avoid power mismatch loss in photovoltaic modules. Current–voltage testers, used by almost any photovoltaic company and research laboratory, are costly to maintain and to adapt to recent and predicted morphological changes in solar cells: larger and thinner wafers, half or shingled cells, a wide range of busbar layouts, and more. In this study, we challenge this fundamental technique and propose to bin solar cells and detect defective cells based on a deep learning analysis of their electroluminescence images. The use of electroluminescence imaging addresses the above‐mentioned limitations of the current–voltage technique, as well as allowing faster measurements as it avoids any capacitance effects. By introducing LumiNet, a convolutional neural network end‐to‐end framework, solar cell efficiency bins can be accurately predicted from electroluminescence imaging with a mean error similar to that obtained by current–voltage measurements. The proposed framework is validated on several state‐of‐the‐art mono‐crystalline silicon solar cell structures. We show that photovoltaic modules fabricated using the proposed method would have similar mismatch loss as the traditional current–voltage binning. We then demonstrate the method on half‐cut silicon solar cells. Predicting the half‐cut cell efficiencies, from the deep learning framework, enables manufacturers to assess post‐cutting damages and reassess their binning strategy before module assembly. Furthermore, the deep learning framework is shown to work well even on datasets that have not been previously seen. The trained deep learning LumiNet models' structure and weight are shared with the community to accelerate the adaptation of deep learning for luminescence image analysis in the photovoltaic industry.
Interaction of maternal asthma history and plasma folate levels on child asthma risk in the Boston Birth Cohort
Authors: Wang You , Hong Xiumei , Yao Tsung‐Chieh , Tsai Hui‐Ju , Wang Xiaobin 
Published: October 2021

AbstractBackgroundPrevious studies on maternal folate status during pregnancy and child asthma risk yielded mixed results, and few considered maternal asthma history, a known risk factor of childhood asthma. This study examined whether the role of maternal folate in childhood asthma differs by maternal asthma history and whether there is an interaction between the two factors.MethodsThis study included 1948 mother–child dyads from the Boston Birth Cohort. Childhood asthma was defined based on physician diagnosis documented in electronic medical records, and maternal asthma was based on standard questionnaire interview. Maternal plasma folate level within a few days of delivery was measured by chemiluminescent immunoassay. Logistic regression models were applied to examine individual and joint associations of maternal asthma history and plasma folate level with childhood asthma, adjusting for other covariables.ResultsWhen stratified by maternal asthma history, an L‐shaped relationship between maternal folate level and child asthma was observed in children born to mothers with asthma history (pinteraction = 0.03). The highest risk was found in children having maternal asthma history and low maternal folate level (odds ratio = 5.93; 95% confidence interval: 2.86–12.3) compared with children without maternal asthma history and with sufficient maternal folate levels. Sensitivity analyses using different definitions of asthma and stratified by major covariables yielded similar findings.ConclusionIn this US prospective high‐risk birth cohort, maternal asthma history and low folate level interactively increased the risk of child asthma. If further confirmed, optimizing maternal folate levels during pregnancy may mitigate child asthma risk in the setting of maternal asthma history.
A high‐efficient nano pesticide‐fertilizer combination fabricated by amino acid‐modified cellulose based carriers
Authors: Zhao Ming , Zhou Hongjun , Hao Li , Chen Huayao , Zhou Xinhua 
Published: October 2021

AbstractBACKGROUNDAs the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers. Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.RESULTSIn this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC‐PGMA‐GLY. A nanopesticide EB@CMC‐PGMA‐GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion. The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release. Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination. The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.CONCLUSIONSThis environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture. © 2021 Society of Chemical Industry.
The triple exponentially weighted moving average control chart for monitoring Poisson processes
Authors: Alevizakos Vasileios , Chatterjee Kashinath , Koukouvinos Christos 
Published: October 2021

AbstractIn many real applications, the quality characteristics of interest, such as the number of nonconformities in a production unit or the annual incidence rate, may follow the Poisson distribution. In the present article, we propose a triple exponentially weighted moving average control chart for monitoring Poisson processes (regarded as PTEWMA chart). One‐ and two‐sided schemes of the proposed chart are designed and are compared with the existing PEWMA and PDEWMA charts in terms of the average run‐length (ARL). The results show that for small values of the smoothing parameter , the PTEWMA chart is more effective than its competitors in detecting small shifts while its superiority increases as the value of increases. Moreover, the two‐sided PTEWMA chart is less ARL‐biased for small downward shifts than the other two charts. Two illustrative examples are provided to demonstrate the application of the proposed chart.
A novel trophectoderm biopsy technique for all blastocyst stages
Authors: Mizobe Yamato , Kuwatsuru Yukari , Kuroki Yuko , Fukumoto Yumiko , Tokudome Mari , Moewaki Harue , Watanabe Mia , Iwakawa Tokiko , Takeuchi Kazuhiro 
Published: October 2021

AbstractPurposeThis study was conducted to assess the effectiveness of a new trophectoderm (TE) biopsy method that does not require prior opening of the zona pellucida at the blastocyst stage.MethodsTE biopsy was conducted using a modified extrusion method for embryos during the cleavage stage. In this method, culture medium was injected into the perivitelline space to help extrude TE cells from the zona pellucida before TE biopsy.ResultsOur extrusion method preserves the embryo culture environment until immediately before biopsy because it does not require opening of the zona pellucida prior to TE biopsy. Furthermore, this method does not require a waiting time for blastocyst hatching after laser irradiation, thereby minimizing damage to the embryos and maintaining the time schedule of culture operations.ConclusionsTE biopsy using this novel extrusion method may be useful in various applications, including the collection of TE cells for next‐generation sequencing analysis.