bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective Medicine Treatment for Corona Patients at Home in COVID 19 Pandemic - and Roles of Nurses and Doctors for Heart Failures Treatment Attached
Authors: Binh Vu Thanh , Huy Dinh Tran Ngoc , Ngoc Pham Thi Bich , Nhung Pham Thi Hong , Hien Dinh Tran Ngoc , Hoang Ngo Huy 
Published: October 2021

In the case of developing countries such as Vietnam, we will have a new approach of attacking corona virus and help patients at home with effective medicine treatment solutions as presented in this paper, it will help other nations as well and they can use it as reference.
Authors will use qualitative analysis and experience and expertise from experts to explore this solution.
Our study results show that there are several methods to treat corona patients at home effectively and that are tested in some countries including Vietnam. Currently Vietnam is testing Molnupiravir and other methods of treatment which will be presented, while WHO and Japan also have other approaches as presented in the study. Last but not least, authors suggest treatment of heart failures attached for patients and self-care knowledge for these patients.
A Estranha Liberdade de Odiar: uma análise do processo de Ação Civil Pública contra a resolução 01/2018 do Conselho Federal de Psicologia
Authors: Cavalcanti Céu , Carvalho Marina Wanderley Vilar , Bicalho Pedro Paulo Gastalho 
Published: October 2021

Em janeiro de 2018 o Conselho Federal de Psicologia publica a resolução CFP 01/2018, que “estabelece normas de atuação para as psicólogas e os psicólogos em relação às pessoas transexuais e travestis”. Tal resolução prevê entre outras coisas, a necessidade de perspectivas despatologizantes no atendimento com pessoas trans, o fundamental respeito às autodeterminações de gênero e a perspectiva analítica de pensar em termos de cisnormatividade sobre as relações de poder que atravessam as constituições de corpos trans e corpos não trans. Sendo um documento construído em diálogo com pesquisadoras, com profissionais de psicologia e com ativistas dos movimentos trans, ela rapidamente foi entendida como um avanço imenso em termos de legislação protetiva para a população trans. Apenas dois dias seguintes a publicação, o Ministério Público Federal em sua 4ª seção prepara uma Ação Civil Pública (ACP) contrária à resolução, alegando que esta configurar-se-ia uma grave ameaça à liberdade de expressão e de pensamento dos profissionais de psicologia no Brasil. Temos como objetivo nesse texto colocar em análise o processo da ACP entendendo este como um dispositivo que faz ver e falar racionalidades que atravessam as diferentes relações institucionais e profissionais com pessoas trans. A inconsistência argumentativa revela movimentos que podemos entender como relações entre a produção de verdade em processos jurídicos e a disseminação de discursos de ódio. O ódio às diferenças, aqui entendido como ódio transfóbico, mobiliza aparatos os mais diversos que vão desde o enfrentamento direto que culmina em assassinatos brutais, quanto o apagamento de pautas e tentativas de boicote a pequenos avanços em medidas de proteção e garantia, como parece ser o caso desta ACP. Após uma breve disputa discursiva, o processo foi extinto sem julgamento de mérito, porém, ele nos sinaliza que nessa senda, outros ataques certamente virão. E de fato já veio, em forma de insistência jurídica. Enquanto se faz necessária a construção de proteções às diferenças em diferentes campos, entendemos a grande importância de estarmos atentas a uma estranha organização de discursos, que a uma só vez se compõe como discursos de verdade, que as vezes nos fazem rir, mas que tem o poder institucional de matar.
High‐Harmonic Optical Vortex Generation from Photonic Bound States in the Continuum
Authors: Kang Lei , Wu Yuhao , Ma Xuezhi , Lan Shoufeng , Werner Douglas H. 
Published: October 2021

AbstractStemming from bound states in the continuum (BICs), momentum‐space polarization vortices observed in photonic structures provide an attractive approach to generating optical vortex (OV) beams. On the other hand, dominated by the selection rules, the harmonic generation from nanostructures exhibits a nonlinear geometric phase that depends on both the harmonic orders and the handedness of circularly polarized harmonic signals. Here, the third‐ and fifth‐harmonic optical vortex generation from an amorphous silicon photonic crystal slab, supporting the guided resonance associated with BICs at near infrared wavelengths, is numerically demonstrated. The results show that, determined by the nonlinearity phase, the topological charge (lnω) associated with the nth‐harmonic OV beams follows σ(n∓1)q, where q is the polarization charge of the BIC and the ∓ sign represents the opposite or same polarization of the nth‐harmonic signal relative to the circular polarization state (σ) of the fundamental waves. Exploiting harmonic multiplexing, this approach can significantly improve the channel capacity of OV generators based on topologically protected optical BICs.
Unraveling the Enhanced Kinetics of Sr2Fe1+xMo1‐xO6‐δ Electrocatalysts for High‐Performance Solid Oxide Cells
Authors: Xi Xiuan , Liu Jianwen , Luo Wenzhi , Fan Yun , Zhang Jiujun , Luo Jing‐Li , Fu Xian‐Zhu 
Published: October 2021

AbstractThe performance of Sr2FeMoO6–σ double perovskites can be significantly enhanced by optimizing the ratio of Fe/Mo as a promising electrode material for solid oxide fuel/electrolysis cells. However, the intrinsic origin is still doubt for the improvement of Sr2FeMoO6–σ sluggish electrocatalytic reaction kinetics. Herein, their electronic structures are investigated by partial replacement of Mo with Fe ions. As the Fe content in Sr2Fe1+xMo1–xO6–δ is increased, its oxidation state increases, which enhances the metal–oxygen hybridization and shifts its bulk O p band energy toward the Fermi level. These electronic and structural variations decrease the O‐vacancy formation and migration energy, which, in turn, facilitates the formation of more oxygen vacancy defects and O ion transport, promoting the full contact between analytes and active B‐site transition metals and also the catalytic reaction kinetics. Consequently, the solid oxide cells with optimized Sr2Fe1.5Mo0.5O6–σ electrodes operating at 800 °C demonstrate high power density of 1.24 W cm−2 using H2 as fuel, and large CO2 electrolysis current density of 1.5 A cm−2 at 1.5 V, which are comparable with those of current state‐of‐the‐art Ni‐based catalysts. The findings provide a new understanding for the origin of the enhanced reaction kinetics of Sr2Fe1+xMo1–xO6–δ serial materials by increasing Fe doping.
Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis
Authors: Ito Daisuke 
Published: October 2021

Nucleic acid therapeutics have been attracting attention as novel drug discovery modalities for intractable diseases, including amyotrophic lateral sclerosis. This review provides an overview of the current status and prospects of antisense oligonucleotide treatment for amyotrophic lateral sclerosis. Recently, the results of a phase I/II study using the antisense oligonucleotides Tofersen to treat familial amyotrophic lateral sclerosis with superoxide dismutase 1 mutation have been reported. Intrathecal Tofersen administration resulted in a 36% reduction in superoxide dismutase 1 level in the cerebrospinal fluid. Another report described 2 patients with mutant superoxide dismutase 1 treated with an adeno‐associated virus encoding a microRNA targeting superoxide dismutase 1. The first patient, who possessed the fast progressive mutant A5V, received a single intrathecal infusion. Although the patient died of respiratory arrest 16 months after treatment, autopsy findings showed a reduction of >90% in superoxide dismutase 1 level in the spinal cord. Clinical trials on antisense oligonucleotide therapies targeting other major amyotrophic lateral sclerosis‐causative genes, fused in sarcoma and chromosome 9 open reading frame 72, are ongoing. To attenuate the pathology of TDP‐43, strategies targeting regulators of TDP‐43 (ataxin 2) and proteins downstream of TDP‐43 (stathmin 2) by antisense oligonucleotides are being developed. The advent of nucleic acid therapeutics has enabled to specifically attack the molecules in the amyotrophic lateral sclerosis pathological cascade, expanding the options for therapeutic targets. ANN NEUROL 2022;91:13–20
Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes
Authors: Abdel‐Rahman Laila H. , Basha Maram T. , Al‐Farhan Badriah Saad , Shehata Mohamed R. , Abdalla Ehab M. 
Published: October 2021

In this study, five novel complexes for Co(II), Ni(II), VO(II), Cr(III), and La(III) ions were synthesized from a tridentate NNO monobasic chelating Schiff base ligand, (Z)‐2‐((pyridin‐2‐ylimino)methyl)phenol (HL). Spectral and analytical tools were applied to elucidate the structural compositions of the new compounds. Then, geometry optimization was conducted for all the syntheses by the Gaussian 09 program via the density functional theory method to obtain optimal structures and the most essential parameters. Moreover, the biochemical behaviors of all the syntheses were explored based on the reactivity, which was tested against various cancer cell lines (HepG‐2, MCF‐7, and HCT‐116). The complexes exhibited an interestingly antiproliferative potential against human cancer cell lines, and the cytotoxicities of the new complexes were arranged to follow the order: VOL > CrL > NiL > LaL > CoL > HL. The antioxidant behaviors of the complexes were studied using the DPPH assay, and VOL showed the maximum antioxidant activity, followed by LaL. The antibacterial activities of the HL ligand and its complexes were studied. Moreover, the binding nature of the complexes with calf thymus DNA (CT‐DNA) was investigated based on the spectrophotometric absorption titration, viscosity, and gel electrophoresis methods. The binding ability of the complexes with CT‐DNA was proposed to be just intercalation or replacement mode. The intrinsic binding constant Kb was calculated and arranged based on the following order: VOL (5.2 × 105) > CrL (3.6 × 105) > NiL (3.3 × 105) > LaL (3.0 × 105) > CoL (1.12 × 105) mol−1 dm−3. Docking investigations were performed using the receptors of COVID‐19's main protease viral protein (PDB ID: 6LU7) and Escherichia coli (gram [–ve] bacteria [PDB ID: 1fj4]).
Effect of different cell disruption methods on lipid yield of Schizochytrium sp.
Authors: Hac İsa Mustafa , Metin Cansu , Ercan Ertan , Alparslan Yunus 
Published: October 2021

AbstractIn this study, it was investigated to increase the lipid yield of the microalgae Schizochytrium sp., by applying different cell disruption methods; acid treatment with HCl, osmotic shock, enzyme applications and ultrasonic homogenizer were combined with the Bligh and Dyer or Soxhlet methods. In the Soxhlet method, the lipid and fatty acid yields decreased due to the inability of the method to break down the lipid cells sufficiently and the high temperature application. Enzyme application (hemicellulase treatment at 55°C for 2 days) prior to Bligh and Dyer method (BDE) was found more efficient in terms of lipid and DHA yield compared to other methods. BDE process increased the lipid yield to 21.72 ± 0.74% and DHA content to 19.25 ± 0.09% from lipid yield of 18.87 ± 0.4% and DHA content of 18.41 ± 0.20% by the Bligh and Dyer control (BDC). Major saturated fatty acids were 14:0, 16:0, 18:0, 24:0 and the highest saturated fatty acid was 16:0 (palmitic acid). Lipid health indices such as n‐6/n‐3, PUFA/SFA, atherogenicity index, thrombogenicity index and hypocholesterolemic/hypercholesterolemic ratios were almost favorable. With this study, appropriate lipid extraction methods were studied to provide an economical and environmental friendly suggestion for future studies to be used in areas such as food, feed and cosmetics grade. It was concluded that the most convenient method among the cell disruption methods was BDE owing to lipid and fatty acid yield.
Chemical Composition and Cytotoxic Activity of Eucalyptus torquata Luehm. and Eucalyptus salmonophloia F. Muell. Trunk Bark Essential Oils against Human SW620 and MDA‐MB‐231 Cancer Cell Lines
Authors: Lahmadi Ghofrane , Lahmar Aida , Znati Mansour , Elaieb Mohamed Tahar , Khouja Mohamed Larbi , Ascrizzi Roberta , Flamini Guido , Harrath Abdel Halim , Chekir‐Ghedira Leila , Jannet Hichem Ben 
Published: October 2021

AbstractIn recent years, there has been a growing interest in the screening of natural active ingredients from Eucalyptus essential oils because of their evident importance in practical utility and their undeniable therapeutic properties. Based on this, the aim of the present study was to investigate the chemical profile of the essential oils of the trunk bark of Eucalyptus torquata Luehm. (ETEO), and E. salmonophloia F. Muell. (ESEO), growing in Tunisia. The in vitro cytotoxic properties of the extracted EOs were also evaluated against two human cancer cell lines: breast carcinoma cell lines MDA‐MB‐231 and colorectal cancer cell lines SW620. The analysis by gas chromatography coupled with mass spectrometry (GC/MS) led to the identification of 32 compounds from the ETEO, with the dominant constituents being the monoterpenes trans‐myrtanol (73.4 %) and myrtenol (4.7 %), and the apocarotene (E)‐β‐ionone (3.9 %). In the case of ESEO, 29 compounds were identified with trans‐myrtanol (25.0 %), decanoic acid (22.1 %), nonanoic acid (9.8 %), γ‐elemene (6.5 %), γ‐maaliene (5.5 %), and α‐terpineol (5.3 %) as the main components. The cytotoxicity of EOs against the two chosen cell lines was tested using Crystal Violet Staining (CVS) assay and 5‐fluorouracil as a reference drug. The two EOs exhibited a significant dose‐dependent inhibition against the viability of the used cell lines. Their inhibitory effects were particularly observed towards SW620 colon carcinoma cells with IC50 values of 26.71±1.22 and 22.21±0.85 μg/mL, respectively, indicating that both oils were more cytotoxic for SW620 cells compared to MDA‐MB‐231 one.
An improved secure and efficient group key agreement scheme in VANETs
Authors: Li Xiang , Liu Ping , Zhang Songsong , Xie Yong 
Published: October 2021

SummaryVANET is a wireless mobile network that can provide communication for vehicles and roadside units. The security and efficiency of its key agreement scheme are critical. After analyzing the security defects of the VANET key agreement scheme of Liu et al., an improved secure and efficient group key agreement scheme in VANETs is proposed in this paper. We construct a group key agreement scheme replacing the bilinear pair with elliptic curve cryptography, which can achieve a higher level of security. A strict security analysis is given to prove that the scheme meets various security requirements of VANETs. Compared with similar schemes, the performance analysis shows that the computation cost and communication cost of the proposed scheme are significantly reduced.
Untangling multi‐scale habitat relationships of an endangered frog in streams to inform reintroduction programs
Authors: Brown Cathy , Nowakowski A. Justin , Keung Neil C. , Lawler Sharon P. , Todd Brian D. 
Published: October 2021

AbstractSuccessful reintroductions of endangered species rely on comprehensive knowledge of habitat requirements across spatial and temporal scales. To inform designs of reintroduction programs, we studied habitat selection of the federally endangered Sierra Nevada yellow‐legged frog (Rana sierrae) in streams in its northern range. We quantified multi‐scale habitat use across diverse streams, habitat types within streams, and seasonal flows. In one intermittent stream, we compared habitat selection between wild and captive‐reared frogs that were released as a population augmentation. We analyzed habitat selection of seasonal habitat unit types (e.g., pool, riffle, cascades) and dimensions, and microhabitat hydrology and cover.R. sierraeappeared able to meet its ecological requirements in a variety of habitats. Study streams ranged from third‐order perennial streams to first‐order intermittent headwater creeks. Perennial streams retained a variety of habitats across flows whereas intermittent streams dried to just a few pools. Frogs used all seasonal habitat types but selected deeper pools most often relative to available habitats in intermittent streams and selected riffles or showed no preference in perennial streams. Frogs avoided fast deep‐water microhabitats, but, otherwise, preferred flowing water or deeper water without flow. Our results suggest that diverse streams can be considered candidates for reintroductions. Within intermittent streams, deeper perennial pools may provide more stable release sites, whereas non‐pool habitats may be safer in perennial streams with fish. Importantly, captive‐reared frogs selected similar habitats as wild frogs, suggesting that captivity does not alter habitat selection behaviors post‐release and that reintroduction designs for this species can be based on wild frog preferences. By improving our understanding of how habitat use varies among different types of streams and differs seasonally in response to changing habitat conditions, our results inform the design of effective reintroduction programs for frogs in streams.
Association between hypertension requiring medication and 30‐day outcomes in head and neck microvascular surgery
Authors: Brauer Philip R. , Byrne Patrick J. , Prendes Brandon L. , Ku Jamie A. , Ciolek Peter J. , Jia Xuefei , Lamarre Eric D. 
Published: October 2021

AbstractBackgroundHypertension has been shown to be both a protective factor and a risk factor for complications in head and neck reconstructive surgery.MethodsRetrospective analysis of microvascular free tissue transfer patients using the National Surgical Quality Improvement Program database.ResultsHypertensive patients (n = 1598; 46.9%) had a significantly higher rate of complications, including pneumonia (p < 0.001), myocardial infarction (p = 0.003), and intra/post‐operative transfusion (p < 0.001). In a multivariable model, hypertension was associated with returning to the operating room (OR = 1.45 [95% CI 1.20, 1.76], p < 0.001), post‐operative medical complications (OR = 1.53 [95% CI 1.24, 1.90], p < 0.001), and surgical complications (OR = 1.17 [95% CI 1.00, 1.37], p = 0.047). However, no difference in 30‐day readmission was found (p > 0.05).ConclusionsHypertension is a modifiable risk factor for post‐operative complications in head and neck free tissue transfer, in which prospective studies are required to establish causation. This study may serve as an impetus for proactive recommendations to manage hypertension before undergoing head and neck microvascular surgery.
Feedback‐regulated transcriptional repression of FBXO31 by c‐Myc triggers ovarian cancer tumorigenesis
Authors: Islam Sehbanul , Dutta Parul , Sahay Osheen , Gopalakrishnan Kesavaperumal , Muhury Sushrita Roy , Parameshwar Parinitha , Shetty Praveenkumar , Santra Manas Kumar 
Published: October 2021

AbstractFBXO31, a member of F‐box protein family, has been shown to play an important role in preventing tumorigenesis by preserving genomic stability during cell proliferation as well as upon genotoxic stress. Inactivation of FBXO31 due to loss of heterozygosity is associated with various cancers, including ovarian cancer, one of the deadliest forms of gynecological cancers. However, the role and regulation of FBXO31 in ovarian cancer remained elusive. Here, using biochemical and molecular biology techniques, we show that c‐Myc suppresses the mRNA levels of FBXO31 in ovarian cancer. Chromatin immunoprecipitation experiment showed that c‐Myc is recruited to the promoter region of FBXO31 and prevents FBXO31 mRNA synthesis. In contrast, FBXO31 maintains the c‐Myc expression at an optimum through proteasome pathway. FBXO31 interacts with and facilitates the polyubiquitination of c‐Myc through the SCF complex and thereby inhibits ovarian cancer growth both in vitro and in vivo. Moreover, FBXO31‐mediated proteasomal degradation of c‐Myc is unique. Unlike other negative regulators, FBXO31 recognizes c‐Myc in phosphorylation independent manner to direct its degradation. Further, expression levels analysis revealed that c‐Myc and FBXO31 share a converse correlation of expression in ovarian cancer cell lines and patient samples. We observed an increase in the expression levels of c‐Myc with a concomitant decrease in the levels of FBXO31 in higher grades of ovarian cancer patient samples. In conclusion, our study demonstrated that oncogene c‐Myc impairs the tumor‐suppressive functions of FBXO31 to promote ovarian cancer progression, and therefore c‐Myc‐FBXO31 axis can be explored to develop better cancer therapy.
Social inequalities in treatment receipt for childhood cancers in Ireland: A population‐based analysis
Authors: Molcho Michal , Thomas Audrey A. , Walsh Paul M. , Skinner Roderick , Sharp Linda 
Published: October 2021

AbstractTreatment advances over the past five decades have resulted in significant improvements in survival from childhood cancer. Although survival rates are relatively high, social disparities in outcomes have been sometimes observed. In a population‐based study, we investigated social inequalities by sex and deprivation in treatment receipt in childhood cancer in Ireland. Cancers incident in people aged 0 to 19 during 1994 to 2012 and treatments received were abstracted from the National Cancer Registry Ireland. Multivariable modified Poisson regression with robust error variance (adjusting for age, and year) was used to assess associations between sex and deprivation category of area of residence at diagnosis and receipt of cancer‐directed surgery, chemotherapy or radiotherapy. Three thousand seven hundred and four childhood cancers were included. Girls were significantly less likely than boys to receive radiotherapy for leukemia overall (relative risk [RR] = 0.70; 95% confidence interval [CI] = 0.50‐0.98), and acute lymphoblastic leukemia specifically (RR = 0.54; 95% CI = 0.36‐0.79), and surgery for central nervous system (CNS) overall (RR = 0.83; 95% CI = 0.74‐0.93) and other CNS (RR = 0.76; 95% CI = 0.60‐0.96). Girls were slightly less likely to receive chemotherapy for non‐Hodgkin lymphoma and surgery for Hodgkin lymphoma (HL), but these results were not statistically significant. Children residing in more deprived areas were significantly less likely to receive chemotherapy for acute myeloid leukemia or surgery for lymphoma overall and HL, but more likely to receive chemotherapy for medulloblastoma. These results may suggest social inequalities in treatment receipt for childhood cancers. Further research is warranted to explore whether similar patterns are evident in other childhood cancer populations and to better understand the reasons for the findings.