bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arterial Stiffness Assessment in Children with Familial Hypercholesterolemia
Authors: Sadykova Dinara , Galimova Liliia , Slastnikova Evgeniia , Khabibrakhmanova Zulfiia , Guseva Natalya 
Published: February 2021

Familial hypercholesterolemia (FH) is the genetic disease which characterized by an increase of level total cholesterol and low density lipoproteins since childhood. The aim of the study was to assess arterial stiffness in children with heterozygous FH by measuring the pulse wave velocity (PWV) in the aorta. The study involved 118 children, 60 healthy children in the control group and 58 children with heterozygous FH in the main group. Both groups were divided into 3 age subgroups: 5–7 years old, 8–12 years old and 13–17 years old. The diagnosis of FH was made using British criteria by Simon Broome. The lipid profile was determined for all children, blood pressure was monitored daily with an estimate of the minimum, mean and maximum PWV (PWVmin, mean PWV, PWVmax) in aorta using oscillometric method. Correlation analysis in patients with FH revealed direct correlation between PWVmin, mean PWV and PWVmax with total cholesterol (r = 0.46, r = 0.46 and r = 0.464, respectively, p < 0.001). The study demonstrates an increase in the PWV in the aorta in children with FH compared with healthy peers from 8–12 years of age and a progression of arterial stiffness most significant in the group of 13–17 years.
Numerical Investigation of Heat Transfer and Fluid Flow Characteristics in a Rectangular Channel with Presence of Perforated Concave Rectangular Winglet Vortex Generators
Authors: Syaiful  , Kurnia Lutfi M. 
Published: February 2021

The high thermal resistance of the airside of the compact heat exchanger results in a low heat transfer rate. Vortex generator (VG) is one of the effective passive methods to increase convection heat transfer by generating longitudinal vortex (LV), which results in an increase in fluid mixing. Therefore, this study aims to analyze the convection heat transfer characteristics and the pressure drop of airflow in a rectangular channel in the presence of a concave rectangular winglet VG on a heated plate. Numerical calculations were performed on rectangular winglet pairs vortex generators (RWP VGs) and concave rectangular winglet pairs vortex generators (CRWP VGs) with a 45° angle of attack and one, two, and three pairs of VGs with and without holes. The simulation results show that the decrease in the value of convection heat transfer coefficient and pressure drop on CRWP with three perforated VG configuration is 4.63% and 3.28%, respectively, of the three pairs of CRWP VG without holes at an airflow velocity of 2 m/s.
Control of an Epidemic of SARS-CoV-2 by Assessing Transmissibility of Its Infected Cases in Absence of a Suitable Vaccine
Authors: Sarkar Bidisa , Sarkar Kamalesh 
Published: February 2021

SARS-CoV-2 or Covid 19 and it’s pandemicity has been wreaking havoc in many countries worldwide. It is important to counter and contain the spread of Covid-19 using some effective infection control policies as we await an effective protection such as vaccine. Ahmedabad Model of Covid-19 Control could be used as an established epidemic management protocol for COVID 19 infection. It relies on the Cycle Threshold (Ct) Value, which was used as a proxy marker for assessing initial viral load. It was evident that cases with higher viral load spread the disease at much higher rate as compared to that of low viral load apart from population mobility and/or population density. Therefore, Ct value based segregation of infected cases with higher viral load along with contact tracing of them of previous 5 days is an effective epidemic control policy. It needs to be remembered that a section of infected cases is asymptomatic and capable of spreading infection in the community unknowingly. Hence, infection control practices must be accompanied with standard precautionary measures such as physical distancing, hand hygiene and wearing face mask. Community awareness is an integral part of it. Newer biotechnology based researches may be encouraged based on felt needs.
Evaluation of Corneal Optic Quality in Amblyopia
Authors: ÖNCÜL Hasan 
Published: February 2021

Objective: To compare corneal aberrations and densitometry values in children with amblyopia due to anisometropic hyperopia with those of healthy children.
Methods: This study included 173 children with amblyopia due to hyperopic anisometropia in one eye and 173 children with both healthy eyes. The amblyopic eye (Group 1) and the fellow normal eye (Group 2) of the amblyopic patients and the right eye of the healthy control group (Group 3) were evaluated. Of the corneal aberration and corneal densitometry (CD)measured using Scheimpflug corneal topography values were noted.
Results: While there was a significant difference in total root mean square (RMS), higher-order aberration (HOA) RMS, coma horizontal, trefoil horizontal and spherical aberration values between the groups (p
Apoptotic and Anti-inflammatory Effects of Hypericum Perforatum Extract in Human Basal Cell Carcinoma TE 354.T Cell Line
Authors: CELİK Ebru 
Published: February 2021

Objectives: Basal cell carcinoma is the most common malignancy in in the Caucasian race and is a serious health problem with its ever-increasing incidence and high cost. Although the treatment is surgical, some elderly patients do not accept surgical intervention. In this case, non-surgical treatments come into prominence. The Hypericum perforatum (HP) / St. John's Wort plant has been used in the treatment of many diseases for centuries among local people. Here, we aimed to aimed to elucidate the effect and molecular mechanism of the HP plant on BCC cells.
Methods: Human BCC cell lines TE 354.T were acquired from ATCC®, then were cultured in Dulbecco's Modified Eagle's Medium. BCC cells were seeded at a concentration of 2x106cells in each flask (n=12). After incubation, while six of the flasks were applied with a 0.8% HP extract and 99.2% medium for 48 hours, no application was made to the control group. The effects of HP on mitochondrial mediated intrinsic and extrinsic apoptotic pathway agents, cell cycle G2 / M checkpoint kinases and inflammatory mediators were investigated in BCC cancer cells. The expression and activities of these mediators in both groups were evaluated by ELISA test.
Results: It was determined that HP extract treatment increased the expression of apoptotic proteins (AIF, GADD153, GRP78, caspase-3, Bax) and cell cycle G2 / M checkpoint kinase (Wee1), though it reduced antiapoptotic protein (Bcl-2) and inflammatory mediators (iNOS, COX-2, cPLA2, NFkB) in BCC cell lines.
Conclusion: HP extract can support routine chemotherapy on BCC cells with its apoptotic, anti-inflammatory and anti-cancer effect, and may be a beacon of hope in reducing resistance to chemotherapeutic drugs in the treatment of BCC.
Effect of Rhizobium and Phosphate Solubilizing Bacteria Inoculation on Growth and Yield Performance of Lathyrus (Lathyrus sativus L.) in Chhattisgarh Plains
Authors: Sahu Balram , Singh Anup Kumar , Chaubey Anand Kumar , Soni Ravindra 
Published: February 2021

The study was conducted at the College of Agriculture and Research Station, Indira Gandhi Krishi Vishwavidylaya, Janjgir- Champa (Chhattisgarh), during the year 2017-18 Rabi Season to Study the Influence of Rhizobium and phosphate solubilizing bacteria on the performance of field-grown Lathyrus (Lathyrus sativus L) under climatic conditions of Chhattisgarh plains. In the present investigation total of 8 treatments T1 -Control (No inoculum no fertilizer), T2- Recommended Dose of Fertilizer RDF(N:P: K::20:40:20), T3- Rhi.HG-25 (Std.) + PSB-H-27 (Std.), T4 Rhi.HG-25 + Korba PSB-118, T5 - Rhi.L-3 Lathyrus + PSB-H-27, T6 Rhi.L-3 Lathyrus + Korba PSB-118, T7- Rhi.L-11 Lathyrus + PSB-H-27 , T8 Rhi.L-11 Lathyrus + Korba PSB-118. Recommended Dose of Fertilizer (RDF) T2 recorded maximum and significantly higher value of plant height over rest of the treatments at 45, 60 DAS and at maturity except T7 (Rhi.L-11 Lathyrus + PSB-H-27) treatment which was statistically similar at maturity. A general perusal of the data of the fresh plant reveals that T2 (Recommended Dose of Fertilizer, RDF) recorded the maximum and significantly higher value of fresh weight over the rest of the treatments at a later stage of crop growth i.e 60 DAS and at harvest. A critical perusal of the nodule count data revealed that treatment T8 (Rhi.L-11Lathyrus+ KorbaPSB-118) was found superior over all the treatments showing the superiority of combined use of local strains over other strains and RDF. In case of grain yield the maximum grain yield were observed in 1451.39 kg/ha due to application of T8 (Rhi.L-11Lathyrus+ KorbaPSB-118) followed by T2 RDF 1415.28 kg/ha, T4 (Rhi.HG-25 +KorbaPSB-118)1388.89 kg/ha, T7 (Rhi.L-11 Lathyrus+ PSB-H-27)1344.44 kg/ha, T6 (Rhi.L-3 Lathyrus­ + PSB-H-27)706.94 kg/ha, 12.77 kg/ha, T5 (Rhi.L-3 Lathyrus+ PSB-H-27) 1216.67 kg/ha, T3 (Rhi.HG-25 + PSB-H-27) 1219.94kg/ha. Maximum grain yield was observed due to the application of effective local strains of rhizobia and PSB which also enhanced the nodulation activity due to an increase in the available soil phosphorus. The maximum and significantly higher value of grain yield straw yield (1118.06 kg/ha) was observed due to treatment T8 (Rhi.L-11 Lathyrus+ Korba-PSB-118) which was statistically superior over all the treatments except T2 RDF.
New Media and Crime among Adolescents in Anaocha LGA of Anambra Nigeria
Authors: Adogu Chelsea C. , Chineke Henry N. , Adogu Prosper O. U. , Ubajaka Chika F. , Chizoba Amara F. , Nduka Chinelo C. 
Published: February 2021

New media use has been recently understood as an important issue to be looked into among adolescents, parents and others who deal with adolescents. This study sought to examine the new media and crime among adolescents in Anaocha Local Government Area of Anambra State. The study employed the cross-sectional descriptive design method involving a quantitative approach which included a survey of 224 adolescents between the ages of 13-19 years selected by cluster and simple random sampling techniques from five communities in the LGA. The instrument for data collection was interviewer-administered questionnaire while the Statistical Packages for Social Sciences (SPSS) was used in analyzing the data. Findings revealed that phones were the most prevalent new media in use among adolescents particularly the male ones. Also, majority expressed negative view about the influence of the new media on adolescents, with sexting and cyber-bullying as the most common crimes associated with new media. Furthermore, psychological trauma was identified as the major effect of cyber-bullying on adolescent victims. This study recommended enlightenment of adolescents and other stakeholders in order to curtail the level of crimes committed through the new media. Parents and significant others are advised to keep a close watch on their adolescent children and wards while they are browsing the internet, and this will hopefully control criminal activities associated with new media use among adolescents in Anaocha LGA in particular and Nigeria in general.
L-Citrulline Supplementation Enhances Reproductive Functions of Lead Acetate Induced Testicular Toxicity in Male Sprague Dawley Rats
Authors: Kolawole Tolunigba Abisola , Oluwatayo Beatrice Olatundun , Ilochi Ogadinma , Umoren Elizabeth , Dapper Datonye Victor 
Published: February 2021

Introduction: Lead (Pb) is a transition metal and a known male reproductive toxicant that induces its effects mainly through oxidative stress. This study investigated the effects of L-Citrulline (Cit) supplement on reproductive functions and antioxidant activities in Lead acetate treated male rats. Materials and Methods: Twenty male rats (180-200 g) were grouped into four and treated as follows; Group 1 (Control), given distilled water, Group 2 was given Pb acetate (2.25mg/kg), Group 3 was co-treated with Pb acetate (2.25mg/kg) and Cit (900mg/kg) and Group 4 was given Cit (900mg/kg) only. All administrations were done orally for thirty days. Caudal sperm, serum hormone levels and testicular antioxidant activities and Nitric oxide levels were evaluated at the end administrations.
Results: Results showed decrease (p<0.05) in sperm morphology, count, viability, motility, FSH, LH, Testosterone, Catalase, Nitric Oxide and Super oxide dismutase in Group 2(Pb treated rats), when compared to Group 1(Control).However, in Group 3 (Pb acetate co-administered with Cit) the effect was significantly reversed (p<0.05) compared with Group 2 and significant increase was observed in Group 4 (Cit only group) compared with Group 2.
There was an increase (p<0.05) in Malondialdehyde level in Group 2 compared with (Group 1) Control while a significant decrease (p<0.05) was observed in Groups 3 and 4 compared with Group 2.
Conclusion: The results of this study suggest that L- Citrulline supplement has ameliorating capacity on the toxic effect of Lead acetate on sperm parameters.
Neoadjuvant Chemotherapy and Concomitant Boost Radiotherapy in the Treatment of Locally Advanced Rectal Cancer
Authors: Abdelazez Mai AbdAllah , Eteba Soumaya Mohamed , Elzahhaf Eman Hamza , Aziz Sameh Roshdy Abdel , Omar Rehab , Abdallah Eman Awad 
Published: February 2021

Aims: This study aimed to examine the efficacy and toxicities of concomitant boost three-dimensional conformal radiotherapy along with multidrug chemotherapy (capecitabine and oxaliplatin) in neoadjuvant course for locally advanced rectal cancer (LARC).
Study Design: A phase II interventional nonrandomized study.
Place and Duration of Study: This Study was conducted at Clinical Oncology and nuclear medicine department of Mansoura University Hospitals (Egypt) between November 2016 and October 2019.
Methodology: Thirty patients (18 women, 12 men; age range 18-75 years) with (cT3-T4 and/or cN+) histologically confirmed rectal adenocarcinoma located within 12 cm of the anal verge were included in this study. Patients received three-dimensional conformal radiotherapy (3DCRT) to the pelvis of 45 Gy and a concomitant boost of 10 Gy to the primary tumor in 25 fractions, and concurrent with oxaliplatin (50 mg/m2 d1 weekly) and capecitabine (625 mg/m2 bid d1–5 weekly). Radical surgery was scheduled six to eight weeks after chemoradiation. Acute toxicities were recorded according to Common Terminology Criteria for Adverse Event (CTCAE) v5.0. Potential prognostic factors were evaluated using a binomial logistic regression. Survival curves were estimated using the Kaplan-Meier method and compared with Log-rank test.
Results: All patients received chemoradiation. Twenty-seven patients underwent surgical resection. Twenty-five patients underwent sphincter-sparing surgery (92.6%) and nine patients (33.3%) achieved pathological complete response (pCR). The incidences of grade III neutropenia, diarrhea, and radiation dermatitis were 6.7%, 6.7%, 3.3% respectively. The three-year local recurrence (LR), disease-free survival (DFS) and overall survival (OS) rates were 7.4%, 63% and 74.1%, respectively. We found pre-surgical negative nodal status to be significantly associated with pCR (p=0.009). The pathological nodal stage was an independent prognostic factor to DFS.
Conclusion: The combination of oxaliplatin, capecitabine, and dose escalation using concomitant boost 3DCRT is safely administrated in patients with locally advanced rectal adenocarcinoma and it offers high pCR and sphincter preservation rate.
The Psychological Impact of Educational Process Disturbance upon COVID- 19 Pandemic among Primary School Students and Their Parents in the Gaza Strip
Authors: Saleh Sally , Habib Azzam Abu , Hamam Rawya , Aita Said Abu , Alzir Mohammed , Jourany Heba , Ziada Hassan , Harb Sahar , AbuJamei Yasser 
Published: February 2021

Aims: At this study we aimed at exploring the psychological impact of educational process disturbance upon the COVID-19 pandemic on the parents and primary school students in the Gaza Strip in order to provide the decision-makers with systematic results that can form a base for short- and long-term plans related to improving the mental health of the population of Gaza.
Study Design: This study was an explorative qualitative study.
Place and Duration of Study: The study was conducted in the Gaza Strip between July and September 2020.
Methodology: we conducted 30 individual semi-structured interviews with (18 women, 12 men; age range 27- 50) from the five governorates of the Gaza Strip. The interviews were transcribed and analyzed by the content thematic analysis using MAXQDA software to find out the common themes and codes.
Results: Our findings showed that the mental health of the parents was significantly affected due to the fear of catching the infection, the quarantine, the burden of distance learning, and the social disruption. They reported symptoms of anxiety, stress, depression, fear and loneliness. Moreover, the mental health of the children was impacted negatively as they showed different behavioral, psychological, and social problems that stemmed from the fear of the pandemic, the fear of the protective measures, the closure of schools, the unexpected alternative educational methods, the quarantine and lack of outdoor activities.
Conclusion: The mental health of both parents and children was negatively affected due to the educational process disturbance upon COVID-19 pandemic in the Gaza Strip, as a result, they need systematic programs that are directed towards improving the mental health and enhancing the mature coping mechanisms in order to overcome the negative consequences of the COVID-19 pandemic on top of the combined effects of the Israeli occupation and the siege.
Comparative Assessment of Glomerular Filtration Rate (GFR) Google APPs and CKD Prepare GFR India Google App
Authors: Shah P. B. , Jeyaseelan L. , Soundararajan P. , Sathiyasekaran B. W. C. 
Published: February 2021

Aim: Glomerular filtration rate (GFR) estimation is an important parameter for assessment of kidney function and management of the patient with suspected kidney function. These mobile applications hence change the way better patient care is managed. In the research project, there is an attempt to perform comparative assessment of GFR Google APPs and CKD PREPARE GFR India Google APP.
Methods: Google app store was searched to identify all the applications which may help in estimation of GFR. All the application were compared except general medical calculators and non-English applications. All important parameters were identified with the guidance of delphi group and comparison chart was made.
Results: The search of Google play store led to 35 mobile applications related to GFR estimation. The majority of the applications were by IT company developers and few were by associations or individuals. There are few companies who have developed multiple mobile applications with different formulas. Many of these aspects of the mobile applications which are considered had important parameters. Few of the applications have multiple page interfaces which may lead to multiple clicks before reaching to GFR estimation which may be at times may be difficult in case of large amounts of use.
Conclusion: All the GFR estimation applications are comparable. Single user interface applications have advantages over others where all the data can be entered and results are available in a single view. The disclaimer of using calculators under medical guidance of a qualified physicians is always required.
Knowledge and Attitude of Dental Students and Interns in Saudi Arabia (Riyadh Region) among Hepatitis C Virus Infection
Authors: Alhedyan Faisal Suliman , Alqhtani Nasser , Alharbi Abdulaziz Rabah , Alasimi Khalid Saud , Alomran Ahmad Ibrahim , Aldibas Ali Othman , Alotibi Abdulrhman Motlaq 
Published: February 2021

Introduction: Hepatitis C virus (HCV) is considered one of the leading causes of chronic liver conditions in the world. The primary route of transmission of HCV can be by exposure of infected blood or sharing a contamination syringe during the injection of drugs. the purpose of this research to evaluate and assess the knowledge and attitude of HCV infection among dental students and interns in Saudi Arabia population specially Riyadh region.
Materials and Methods: This is a cross sectional-based survey, using a questionnaire which was divided into two parts, first covering sociodemographic information of the participant regards gender, demographic variable, academic level of the participant and the University. Second part of the questionnaire was established based on the knowledge and attitude of the participant in regard to HCV.
Results: A total of 218 students participated in this study. The responses of participants differed in various academic levels with a statistically significant difference in only two questions; in question 10 when they were asked whether or not they knew that a vaccine for HCV exists (p = 0.02) and question 20, if they believed that dental staff would be afraid to treat a patient if they found out his/her positive HCV status (p = 0.02).
Conclusions: The present study showed that knowledge, among the dental students and interns in the Riyadh region was not adequate in regard to HCV, and their attitude toward HCV patients was inequitable.
Frequency, Associated Symptoms and Prognosis of Intussusception in Tertiary Care Hospital of Province Sindh
Authors: Shaikh Noor Ahmed , Napar Nabi Bux , Bhatti Zulfiqar Ali , Rahman Hameed Ur , Mahtam Ishrat , Abbas Syed Sohail 
Published: February 2021

Background: Intussusception is an important disease of childhood & has been recognized since ancient time. It commonly involves young infants of 3 ½ months to 10 months of age. Diagnosis is mostly clinical on the basis of classical triad or quarter of pain in abdomen, vomiting palpable abdominal mass and currant red jelly stools. It is confirmed by ultrasound, barium enema which also has a therapeutic potential. The parents in our region lacks awareness regarding the intussusception. They usually bring the child to hospitals after trying various homemade or herbal remedies. The delay in diagnosis always results in severity in symptoms and aggressive mode of treatment.
Objective: The current study was aimed to identify the Frequency, associated symptoms and post-operative complications of intussusception in tertiary care hospital of Province Sindh
Methodology: It was a cross sectional study conducted from July 2017 to June 2020 at department of Pediatric Surgery Ghulam Mohammad Mahar Medical College Teaching Hospital Sukkur. Data regarding symptoms and prognosis was noted on the file of patient and written informed consent was taken from parents. Data was analyzed by using SPSS version 20. Chi square was applied as test of significance at 95%confidance interval and p-value less than 0.05 was considered as significant.
Results: Fourty patients of intussusceptions were reported the mean age was 5.88 ± 1.5 months while 8 (20%) patients were 1to10 years with mean age of 3.88± 3.18 years. Thirteen (32.5%) patients presented within 24 hours of onset of symptoms and 27 (67.5%) presented after 24 hours 19 (47.5%) patients had history of diarrhea while 6 (15%) patients had respiratory tract infection. The most common postoperative complication was gut gangrene.
Conclusion: In three years of study we found only 40 children who came to our hospital with diarrhea and the triad i.e. abdominal pain, abdominal mass and bleeding per rectum. Ultrasound abdomen was found to be best diagnostic modality with impressive accuracy rate at our setup. Gut gangrene was postoperative complication and recurrence was uncommon.