bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrinsic neural network dynamics in catatonia
Authors: Sambataro Fabio , Hirjak Dusan , Fritze Stefan , Kubera Katharina M. , Northoff Georg , Calhoun Vince D. , Meyer‐Lindenberg Andreas , Wolf Robert C. 
Published: September 2021

AbstractCatatonia is a transnosologic psychomotor syndrome with high prevalence in schizophrenia spectrum disorders (SSD). There is mounting neuroimaging evidence that catatonia is associated with aberrant frontoparietal, thalamic and cerebellar regions. Large‐scale brain network dynamics in catatonia have not been investigated so far. In this study, resting‐state fMRI data from 58 right‐handed SSD patients were considered. Catatonic symptoms were examined on the Northoff Catatonia Rating Scale (NCRS). Group spatial independent component analysis was carried out with a multiple analysis of covariance (MANCOVA) approach to estimate and test the underlying intrinsic components (ICs) in SSD patients with (NCRS total score ≥ 3; n = 30) and without (NCRS total score = 0; n = 28) catatonia. Functional network connectivity (FNC) during rest was calculated between pairs of ICs and transient changes in connectivity were estimated using sliding windowing and clustering (to capture both static and dynamic FNC). Catatonic patients showed increased static FNC in cerebellar networks along with decreased low frequency oscillations in basal ganglia (BG) networks. Catatonic patients had reduced state changes and dwelled more in a state characterized by high within‐network correlation of the sensorimotor, visual, and default‐mode network with respect to noncatatonic patients. Finally, in catatonic patients according to DSM‐IV‐TR (n = 44), there was a significant correlation between increased within FNC in cortico‐striatal state and NCRS motor scores. The data support a neuromechanistic model of catatonia that emphasizes a key role of disrupted sensorimotor network control during distinct functional states.
Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver
Authors: Urabe Makiko , Hikita Hayato , Saito Yoshinobu , Kudo Shinnosuke , Fukumoto Kenji , Mizutani Naoki , Myojin Yuta , Doi Akira , Sato Katsuhiko , Sakane Sadatsugu , Makino Yuki , Kodama Takahiro , Sakamori Ryotaro , Tatsumi Tomohide , Takehara Tetsuo 
Published: September 2021

Radiation therapy is one of the treatment methods for hepatocellular carcinoma. However, radiation tolerance of the liver is low, and the detailed effect of radiation on liver regeneration has not been clarified. C57BL/6J mice or hepatocyte‐specific p53 knockout (KO) mice (albumin [Alb]‐Cre Trp53flox/flox
) were irradiated with a single fraction of 10 Gy localized to the upper abdomen. We performed 70% partial hepatectomy (PHx) 24 hours after irradiation. Liver regeneration was assessed by proliferation cell nuclear antigen (PCNA)‐ and Ki‐67‐positive hepatocyte ratios and liver‐to‐body weight ratio after PHx. To establish a fibrosis model, CCl4 was orally administered for 8 weeks. The murine hepatocyte cell line BNL CL.2 (CL2) was irradiated with 10 Gy. Irradiation activated p53, induced downstream p21 in the liver, and delayed liver regeneration after PHx. While PHx increased hepatocyte growth factor (HGF) levels and activated Met with or without irradiation in the regenerative liver, it activated Akt and extracellular kinase 1 and 2 (Erk 1/2) less in irradiated mice than in nonirradiated mice. In CL2 cells cultured with HGF, irradiation suppressed cell growth by decreasing phosphorylated Akt and Erk 1/2 levels, which was abolished by small interfering RNA‐mediated p53 knockdown but not by p21 knockdown. Hepatocyte‐specific knockout of p53 in mice abolished the irradiation‐induced suppression of both liver regeneration and Akt and Erk 1/2 activation after PHx. In the fibrotic mouse model, the survival rate after PHx of irradiated p53 KO mice was higher than that of wild‐type mice. Conclusion: p53 but not p21 is involved in the impaired regenerative ability of the irradiated liver.
The need for management education of healthcare management employees
Authors: Jankelová Nadežda , Joniaková Zuzana , Romanová Anita 
Published: September 2021

AbstractSummaryGiven the wide professional discussion on the dominating professional focus of healthcare managers at the expense of management knowledge, the main goal of this paper is to verify the extent, to which management education of healthcare workers affects the level of their management skills.MethodologyThe Descriptive statistics methods have been used to answer research questions regarding the differences in the perception of the managerial skills and their disposition importance between managers with a completed management education and without it. Emphasis was placed on people management skills and communication skills. The research sample consisted of 253 healthcare managers.ResultsManagers with a completed specialized management study are characterized by higher values of entrepreneurial competences and communication skills. They also have exceptional skills in the area of initiator of change. Another significant difference is the higher adaptation of roles and low critique of their subordinates. They are oriented at workers and relationships with them.ConclusionOur results show that management education of healthcare managers significantly contributes to the implementation of newer approaches to people management and the use of the necessary management skills, which are a source of higher efficiency in the context of the present world of work and its challenges.
Internet of Things adoption barriers in the Indian healthcare supply chain: An ISM‐fuzzy MICMAC approach
Authors: Desingh Videsh , R Baskaran 
Published: September 2021

AbstractInternet of things (IoT) plays a significant role in offering a wide range of benefits to the healthcare supply chain. It improves the quality of patient care, reduces the cost of medical procedures, maintaining flawless operations and supports clinical decisions. Despite strong policy interest and vast potential benefits of IoT in the healthcare supply chain, the actual adoption rate is relatively low and it's in the nascent stage in developing countries like India. The objective of this paper is to identify and analyze the potential barriers which would restrain the healthcare industry from adopting IoT. Based on the review of the literature and brainstorming with experts from industry and academia, 14 barriers were identified for IoT adoption. The contextual relationship between the identified barriers was developed using interpretive structural modeling and the obtained results were used as input to fuzzy MICMAC analysis to determine the driving and dependence power of the IoT adoption barriers. From the result, Legal and regulatory standards, Lack of IT Infrastructure are major barriers influencing the adoption of IoT in the healthcare supply chain. The findings will support the decision‐makers to understand the contextual relationship between the IoT adoption barriers in the Indian healthcare supply chain.
A study on heat transfer in three‐dimensional nonlinear convective boundary layer flow of nanomaterial considering the aggregation of nanoparticles
Authors: Mahanthesh B. , Srikantha N. , Mackolil Joby 
Published: September 2021

AbstractThermal systems of solar collectors, electronic cooling, nuclear reactors, and combustion operate at high thermal conditions, and in such circumstances, the density relation of the working fluids with the thermal field may not be linear. The working fluid features are significantly affected by nonlinear density temperature fluctuations. Therefore, a theoretical study of the quadratic Boussinesq approximation (with quadratic density temperature [QDT] variation) and quadratic Rosseland radiation on the three‐dimensional boundary layer dynamics and heat transport of ethylene glycol‐based titania nanomaterial is carried out. The phenomenon of the kinematics of nanoparticle aggregation is also analyzed by considering modified models proposed by Maxwell–Bruggeman and Krieger–Dougherty for thermal conductivity and dynamic viscosity. The flow is induced by the elongation of a flexible flat plate in two directions. A comparison of heat transfer features of linear elongation of the plate and nonlinear elongation of the plate is conducted. The Rosseland radiative heat flux is studied in three different forms. The governing nonlinear equations are treated using apt nondimensionalization, stretching transformation, and then by using the Richardson extrapolation method. The results are presented via plots to analyze the impact of key parameters involved in the model. The magnitude of the nanomaterial temperature is enhanced due to the kinematics of nanoparticle aggregation. Among linear, quadratic, and nonlinear forms of Rosseland radiative heat flux, the quadratic radiative heat is more suitable when QDT is considered. A positive relationship is found between heat transfer and volume fraction and a positive relationship is observed between heat transfer and the QDT factor. The magnitude of the velocities and thermal field is higher for flow driven due to the linear elongation of the plate than the nonlinear case.
TNF-Polarized Macrophages Produce Insulin-like 6 Peptide to Stimulate Bone Formation in Rheumatoid Arthritis in Mice
Authors: Yi Xiangjiao , Liu Xin , Kenney H Mark , Duan Rong , Lin Xi , Schwarz Edward , Yao Zhenqiang 
Published: September 2021

ABSTRACT
The risk of osteoporosis is increased in rheumatoid arthritis (RA). Anti-tumor necrosis factor (TNF) therapy has markedly improved the outcomes of RA patients but does not improve osteoporosis in some reports. This could be a combined result of disease severity and other therapeutic agents, such as glucocorticoids that accelerate osteoporosis progression. We evaluated the effects of anti-TNF therapy on osteoporosis in an animal model of RA and explored the possible mechanisms involved. Six-week-old TNF transgenic (TNF-Tg) mice with early stage erosive arthritis were treated with TNF antibody (Ab) or control immunoglobulin (IgG) weekly for 4 weeks. We found that TNF Ab completely blocked the development of erosive arthritis in TNF-Tg mice, but only slightly increased vertebral bone mass, associated with reduction in parameters of both bone resorption and formation. Similarly, TNF Ab slightly increased trabecular bone mass in tibias of 8-month-old TNF-Tg mice with advanced erosive arthritis. Interestingly, TNFα increased osteoblast differentiation from mouse bone marrow stromal cells (BMSCs) containing large number of macrophages but not from pure mesenchymal progenitor cells (MPCs). TNFα-polarized macrophages (TPMs) did not express iNos and Arginase 1, typical markers of inflammatory and resident macrophages. Interestingly, TPMs stimulated osteoblast differentiation, unlike resident and inflammatory macrophages polarized by IL-4 and interferon-λ, respectively. RNA-seq analysis indicated that TPMs produced several anabolic factors, including Jagged1 and insulin like 6 (INSL6). Importantly, inhibition of either Jagged1 or INSL6 blocked TNFα-induced osteoblast differentiation. Furthermore, INSL6 Ab significantly decreased the expansion of TNF-induced MPCs in BMSCs, and anti-TNF Ab reduced INSL6 expression by macrophages in vitro and in TNF-Tg mice in vivo. We conclude that TPMs produce INSL6 to stimulate bone formation and anti-TNF Ab blocks not only enhanced bone resorption but also the anabolic effect of TPMs on bone, limiting its effect to increase bone mass in this model of RA. © 2021 American Society for Bone and Mineral Research (ASBMR).
Geriatric Nutrition Risk Index: Prognostic factor related to inflammation in elderly patients with cancer cachexia
Authors: Ruan Guo‐Tian , Zhang Qi , Zhang Xi , Tang Meng , Song Meng‐Meng , Zhang Xiao‐Wei , Li Xiang‐Rui , Zhang Kang‐Ping , Ge Yi‐Zhong , Yang Ming , Li Qin‐Qin , Chen Yong‐Bing , Yu Kai‐Ying , Cong Ming‐Hua , Li Wei , Wang Kun‐Hua , Shi Han‐Ping 
Published: September 2021

AbstractBackgroundSystemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The Geriatric Nutritional Risk Index (GNRI) is a simple and useful tool to assess these conditions, but its predictive ability for elderly patients with cancer cachexia (EPCC) is unknown.MethodsThis multicentre cohort study included 746 EPCC with an average age of 72.00 ± 5.24 years, of whom 489 (65.5%) were male. The patients were divided into two groups (high GNRI group ≥91.959 vs. low GNRI group <91.959) according to the optimal cut‐off value of the ROC curve. The calibration curves were performed to analyse the prognostic, predictive ability of GNRI. Comprehensive survival analyses were utilized to explore the relationship between GNRI and the overall survival (OS) of EPCC. Interaction analysis was used to investigate the comprehensive effects of low GNRI and subgroup parameters on the OS of EPCC.ResultsIn this study, a total of 2560 patients were diagnosed with cancer cachexia, including 746 cases of EPCC. During the 3.6 year median follow‐up, we observed 403 deaths. The overall mortality rate for EPCC at 12 months was 34.3% (95% CI: 62.3% to 69.2%), and resulting in rate of 278 events per 1000 patient‐years. The GNRI score of EPCC was significantly lower than those of young patients with cancer cachexia (P < 0.001). The 1, 3, and 5 year calibration curves showed that the GNRI score had good survival prediction in the OS of EPCC. The GNRI could predict the OS of EPCC, whether as a continuous variable or a categorical variable. Particularly, we also found that low GNRI score (<91.959) of EPCC had a worse prognosis than those with a high GNRI score (≥91.959, P = 0.001, HR = 1.728, 95% CI: 1.244–2.401). Consistent results were observed in the tumour subgroups of gastric cancer and colorectal cancer. Notably, similar results were observed in the sensitivity analysis. In the subgroup analysis, the low GNRI has a combined effect with age (<70 years) on poor OS of EPCC. The results of the prognostic risk model found that the lower the GNRI score, the greater the prognostic risk score, and the greater the risk of death in EPCC.ConclusionsFor the first time, this study found that the GNRI score can serve as an independent prognostic factor for the OS of EPCC.
Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
Authors: Rosa‐Caldwell Megan E. , Lim Seongkyun , Haynie Wesley S. , Brown Jacob L. , Lee David E. , Dunlap Kirsten R. , Jansen Lisa T. , Washington Tyrone A. , Wiggs Michael P. , Greene Nicholas P. 
Published: September 2021

AbstractBackgroundDisuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse‐induced muscle atrophy. Little data exist on early mechanisms contributing to onset of these pathologies, nor is it known how they differ between sexes. The purpose of this study was to examine differential and conserved responses to mitochondrial quality control in male and female mice during the development and progression of disuse‐induced atrophy.MethodsOne hundred C57BL/6J mice (50 male and 50 female) were hindlimb unloaded to induce disuse atrophy for 0 (con), 24, 48, 72, or 168 h. At designated time‐points, extensor digitorum longus, gastrocnemius, and soleus muscles were collected for analysis of mitochondrial quality control markers.ResultsOne hundred sixty‐eight hours of disuse resulted in ~25% lower oxidative muscle fibre CSA in both male (P = 0.003) and female (P = 0.02) mice without any differences due to disuse in glycolytic fibres. In male mice, 48 h of unloading was sufficient to result in ~67% greater mitochondrial oxidative stress as assessed by the reporter gene pMitoTimer compared with 0 h (P = 0.002), this mitochondrial stress preceded detectable muscle loss. However in female mice, mitochondrial oxidative stress did not occur until 168 h of disuse (~40% greater mitochondrial oxidative stress in 168 h compared with 0 h of disuse, P < 0.0001). Blunted oxidative stress in female mice appeared to coincide with greater inductions of autophagy and mitophagy in female mice (~3‐fold greater BNIP3 and ~6‐fold greater LC3II/I ratio P < 0.0001 and P = 0.038 respectively). Male mice overall had greater reactive oxygen species (ROS) production compared with female mice. Female mice had a greater induction of ROS within 24 h of disuse (~4‐fold greater compared with 0 h, P < 0.0001); whereas male mice did not have greater ROS production until 168 h of disuse (~2‐fold greater, P < 0.0001). Although all muscle types exhibited some alterations to mitochondrial quality control, such as increased markers of mitophagy and fission, the soleus muscle in both male and female mice exhibited consistent alterations to various markers of mitochondrial quality. Markers of mitochondrial translation were approximately 30–50% lower within 24 h of unloading in both male and female soleus muscle (P value ranges: <0.0001–0.03).ConclusionsDisuse negatively affects mitochondria differentially between sexes during development of muscle wasting. Acutely, female mice may forgo muscle mass to maintain mitochondrial quality compared with male mice. These differences may contribute to divergent clinical manifestations of atrophy.
Polypoid invasive carcinoma of the gallbladder‐Another challenging polypoid neoplasm‐
Authors: Nakanuma Yasuni , Sugino Takashi , Nomura Yoshikatsu , Watanabe Hiroyuki , Terada Takuro 
Published: September 2021

AbstractBackgroundInvasive gallbladder carcinoma generally presents as nodular‐sclerosing growth. Recently, “polypoid invasive carcinoma (PICA)” showing grossly visible polypoid neoplasm and histologically invasive carcinoma with no adenomatous components was proposed as a neoplastic polyp of the gallbladder.MethodsWe herein report five cases of PICA collected from 49 cases of invasive gallbladder carcinoma in comparison with another polypoid preinvasive neoplasm of gallbladder, intracholecystic papillary neoplasm (ICPN).ResultsPolypoid invasive carcinomas were composed of four males and one female with an average age of 74 years. Polypoid lesions were sessile (height ranging from 6 to 10 mm and the largest diameter ranging from 12 to 40 mm), and histologically, polypoid neoplasms presented papillary configuration containing tubular and cribriform components with thin inflammatory, fibrotic stroma. Polypoid carcinoma invaded directly and continuously into the gallbladder wall with destruction of the muscle layer. These patterns of PICA were different from ICPN, showing papillary patterns containing tubular components with fine fibrovascular stalks and with occasional focal stromal invasion but with preserved muscle layer. Post‐operative outcome was not favorable in PICA but was favorable in ICPN.ConclusionsPolypoid invasive carcinoma shared several pathological features with ICPN, such as intraluminal polypoid pattern with papillary configurations, but PICAs were invasive adenocarcinoma with destruction of muscle layer while ICPNs were preinvasive neoplasm with occasional focal stromal invasion, thus both should be differentiated from each other.
Ablation versus medication as initial therapy for paroxysmal atrial fibrillation: An updated meta‐analysis of randomized controlled trials
Authors: Kewcharoen Jakrin , Prasitlumkum Narut , Chokesuwattanaskul Ronpichai , Yi Ruiyang , Jongnarangsin Krit , Bunch Thomas J. , Ranjan Ravi , Navaravong Leenhapong 
Published: September 2021

AbstractBackgroundRecent randomized controlled trials (RCTs) suggest that ablation is superior to antiarrhythmic drugs (AADs) as an initial therapy for paroxysmal atrial fibrillation (pAF) to prevent arrhythmia recurrences. We performed an updated meta‐analysis of RCTs, to include recent data from cryoballoon‐based ablation and to compare arrhythmia‐free survival and adverse events between ablation and AADs.MethodsWe searched MEDLINE and EMBASE from inception to December 2020. We included RCT comparing patients with pAF undergoing ablation or receiving AADs as an initial therapy. We combined data using the random‐effects model to calculate hazards ratio (HR) for arrhythmia‐free survival and odds ratio (OR) for adverse events.ResultsFive studies from 2005 to 2020 involving 985 patients were included (495 patients and 490 patients underwent ablation and medication as initial therapy, respectively). Patients who underwent ablation had higher freedom from atrial tachyarrhythmias (ATs) during the 12‐24 months follow‐up period (pooled HR = 0.48, 95% CI: 0.40‐0.59, P < .001). In a subgroup analysis of ablation method used, both cryoablation group (pooled HR = 0.49, 95% CI: 0.38‐0.64, P < .001) and radiofrequency ablation group (pooled HR = 0.47, 95%CI: 0.35‐0.64, P < .001) showed reduction in AT recurrence compared with AAD group. There were no differences in adverse events including cerebrovascular accident, pericardial effusion or tamponade, pulmonary vein stenosis, acute coronary syndrome, deep vein thrombosis and pulmonary embolism, and bradycardia requiring a pacemaker.ConclusionCatheter ablation (both cryoablation and radiofrequency ablation) is superior to AAD as an initial therapy for pAF in efficacy for reducing AT recurrences without a compromise in adverse events.
Calibration of the temporal drift in absolute and relative Raman intensities in large Raman images using a mercury–argon lamp
Authors: Jakubek Ryan S. , Fries Marc D. 
Published: September 2021

AbstractRaman imaging is a powerful tool for the analysis of astromaterials including meteorites, cosmic dust, and samples returned to Earth by spacecraft. Many astromaterials are heterogeneous on mm‐ or cm‐sized scales requiring the collection of large Raman images with long accumulation times of days to weeks. It is known that the wavenumber and bandwidth calibration of a Raman instrument drifts with time and temperature resulting in significant changes in the observed Raman band over the course of Raman image collection. In this work, we examine the temporal and thermal drift of absolute and relative Raman intensities through the collection of a Raman image. We show that the spectrometer throughput and observed Raman intensities change over time and are correlated to small changes in lab temperature. We propose a method of calibrating for the drift in Raman intensities using a Hg–Ar (mercury–argon) calibration lamp integrated into the Raman instrument. We also show that relative Raman intensities drift with time as a function of temperature as a result of changes to the Raman instrument response function. We developed a method to calibrate the drifting instrument response function using only the calibration lines from the Hg–Ar lamp. Overall, our results elucidate the effects of temporal/thermal drift on Raman intensities and we propose calibration techniques to account for these effects.