bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Earphone Use with Tinnitus and Anxiety/Depression
Authors: Choi Jay Hyug , Park Sung Su , Kim So Young 
Published: December 2021

Objective:
This study aimed to investigate the association of earphone use with audiologic and psychologic factors.

Materials and methods:
Korea National Health and Nutrition Examination Survey 2010–2012 data were collected for participants aged ≥12 years old with earphone use ≥1 hour/day. They were matched to a control group for age, sex, income, and education level. The relationship between earphone use and the hearing thresholds of pure-tone audiometry, tinnitus, and psychologic factors such as depression and anxiety, and other quality of life variables was analyzed using multiple logistic regression tests with complex sampling.

Results:
Among the participants, 22.9% (449/1955) of earphone users and 18.1% (355/1600) of control participants had tinnitus (P < 0.001). Earphone users showed 1.27-times higher odds for tinnitus (95% confidence interval [CI] = 1.09–1.50, P = 0.003). Moreover, 6.5% (128/1955) of earphone users and 5.0% (97/1600) of control participants had anxiety and depressive symptoms (P = 0.033). Earphone users showed 1.32-times higher odds for anxiety and depressive symptoms (95% CI = 1.14–1.52, P = 0.040). Nevertheless, the hearing thresholds were comparable between earphone users and control participants.

Conclusion:
Earphone use was associated with tinnitus and anxiety or depressive symptoms.
Analysis of Studies in Tinnitus-Related Gene Research
Authors: Li Zhi-cheng , Fang Bi-xing , Yuan Lian-xiong , Zheng Ke , Wu Shi-xin , Zhong Nanbert , Zeng Xiang-li 
Published: December 2021

Objective:
Summarize and analyze the current research results of tinnitus-related genes, explore the potential links between the results of each study, and provide reference for subsequent studies.

Methods:
Collect and sort out the research literature related to tinnitus genes included in PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang Data Knowledge Service Platform before December 31, 2019. Then the relevant contents of the literature were sorted out and summarized.

Results:
Fifty-one articles were finally selected for analysis: 31 articles (60.8%) were classified as researches on animal models of tinnitus, and 20 (39.2%) as researches on tinnitus patients. Existing studies have shown that genes related to oxidative stress, inflammatory response, nerve excitation/inhibition, and nerve growth are differentially expressed in tinnitus patients or animal models, and have presented the potential links between genes or proteins in the occurrence and development of tinnitus.

Conclusion:
The research on tinnitus-related genes is still in the exploratory stage, and further high-quality research evidence is needed.
Evaluation of musculoskeletal adverse effects in patients on systemic isotretinoin treatment: A cross-sectional study
Authors: Müge Acar Emine , Şaş Senem , Aybala Koçak Fatmanur 
Published: December 2021

Objectives: This study aims to investigate the frequency of musculoskeletal adverse effects in acne vulgaris patients receiving systemic isotretinoin treatment.
Patients and methods: Between January 2016 and December 2017, a total of 200 severe acne patients (22 males, 178 females; mean age: 21.8±0.4 years; range, 15 to 53 years) who were on isotretinoin treatment were retrospectively analyzed. Data including age, sex, body mass index (BMI), duration of disease, diagnosis, and comorbidities were recorded. Back pain severity was evaluated with the Visual Analog Scale (VAS).
Results: The treatment period was mean 8.5±0.1 (range, 6 to 12) months. The dose of isotretinoin was mean 0.6±0.1 (range, 0.5 and 1) mg/kg. Musculoskeletal side effects were seen in 99 (49.5%) patients. Back pain was reported during the treatment period in 78 (78.7%) patients. The diagnosis was mechanical back pain in 31 (39.7%) and inflammatory back pain in 47 (60.3%) patients. The moderate-severe back pain group received higher cumulative isotretinoin doses than the mild back pain group (p=0.003). The BMI values did not show a significant difference between the patients with and without back pain (p=0.55). There was no significant correlation between the BMI and VAS scores (p=0.06). The VAS scores were found to be correlated with age (p=0.04). Sacroiliitis was diagnosed in four (4%) patients. One (1%) patient was diagnosed with enthesitis. Creatine kinase elevation was reported in 18 (18.1%) patients, while three (3%) patients described myalgia of mild severity.
Conclusion: Low back pain is one of the most common musculoskeletal side effects of isotretinoin treatment that usually resolves with dose reduction. The cumulative dose of isotretinoin does not seem to play a role in the development of back pain, but can determine pain severity. Pain severity is directly correlated with the increasing age. Evaluation of the patients for musculoskeletal side effects during isotretinoin use is important in clinical practice, as it is a common occurrence.
Antioxidant glutathione inhibits inflammation in synovial fibroblasts via PTEN/PI3K/AKT pathway: An in vitro study
Authors: Ting Hao Wen , Huang Lu , Pan Wei , Ren Yi Le 
Published: December 2021

Objectives: In this study, we aimed to investigate whether glutathione (GSH) could decrease the secretion of reactive oxygen species (ROS), reduce inflammation, and modulate the phosphatase and tensin homolog deleted on chromosome 10/phosphatidylinositol 3-kinase/AKT (PTEN/PI3K/AKT) in synovial fibroblasts (SFs).
Patients and methods: A total of 30 DBA/1J female mice were used in this study. The release of ROS in MH7A cells was examined using a ROS assay kit. The effects of GSH on the messenger ribonucleic acid (mRNA) expression and protein levels of inflammatory cytokines were determined via reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) in mouse SFs and MH7A cells, respectively. The PTEN/PI3K/AKT pathway was investigated via Western blotting. The effects of buthionine-sulfoximine (BSO), as an inhibitor of GSH, on these molecules were examined.
Results: The ROS were decreased after GSH treatment, and the mRNA levels of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, matrix metalloproteinase (MMP)-1, MMP-3, were also significantly inhibited after GSH stimulation. However, the IL-10 levels were enhanced, and GSH increased the expression of PTEN. The GSH suppressed the activation of phosphorylated (p)-PI3K and p-AKT. The supplementation of the BSO restored the activation of PI3K/AKT pathway with a high production of ROS. The levels of TNF-α, IL-1β and IL-6 were also elevated, when the BSO was added.
Conclusion: These findings suggest that GSH can act as an inflammatory suppressor by downregulating the PTEN/PI3K/AKT pathway in MH7A cells. These data indicated a novel function of GSH for improving the inflammation of RA SFs and may help to alleviate the pathological process of RA.
IMPLEMENTASI PELAYANAN KESEHATAN MASYARAKAT MELALUI PROGRAM BPJS KESEHATAN
Authors: Hasrillah  
Published: December 2021

Penelitian ini merupakan hasil penelitian yang menggambarkan pelaksanaan BPJS Kesehatan di Puskesmas Kedungkandang Kota Malang. Adapun tujuan dari penelitian ini adalah ingin mengetahui faktor-faktor yang menghambat dan pendukung pengimplementasian program BPJS kesehatan di Puskesmas Kedungkandang, serta ingin mengetahui bagaimana implementasi program BPJS Kesehatan di Puskesmas Kedungkandang.Penelitian ini menggunakan beberapa teori, yaitu Kebijakan Publik, , Kebijakan Pelayanan Kesehatan, Implementasi . Peneliti menemukan 4 faktor yang menghabat proses implementasi program BPJS Kesehatan di Puskesmas Kedungkandang,yaitu pertama, faktor komunikasi atau sosialisasi, sedangkan yang kedua, Faktor Sumber daya baik dari sumber daya manusia sampai sumber daya lainya seperti fasilitas, informasi, kemudian yang ketiga, faktor dispotition atau sikap aparatur birokrasi, dan yang keempat, faktor struktur birokrasi. Metode penelitian yang digunakan adalah kualitatif. Penelitian dilakukan di wilayah Kota Malang, tempatnya di Puskesmas Kedungkandang, Dinas Kesehatan. Teknik pengumpulan data pada penelitian ini adalah dengan observasi, wawancara, dan dokumentasi.
Dari penelitian yang dilakukan bedasarkan studi lapangan dalam bentuk observasi dan wawancara, peneliti menemukan bahwa proses implementasi di Puskesmas Kedungkandang sudah berjalan cukup baik, walau masih ada beberapa kendala yang dihadipi, namun pihak Puskesmas Kedungkandang dan Dinas kesehatan terus membenahi kekurangan-kekurangan yang ada dalam proses implementasi program BPJS dapat berjalan dengan baik.Program BPJS merupakan bentuk reformasi birokrasi di bidang kesehatan, sebab dengan adanya program BPJS masyarakat dapat lebih mudah berobat dan tidak sulit dalam pemberkasan dokumen seperti sistem Kesehatan sebelumnya. Dengan adanya program BPJS diharapkan dapat meningkatkan kualitas dan mutu pelayan kesehatan terhadap masyarakat di Kota Malang.
The PERBANDINGAN METODE ARIMA DAN SARIMA DALAM PERAMALAN PENJUALAN KELAPA
Authors: ARUAN SARA SEPTIANA 
Published: December 2021

Objektif. Peramalan dilakukan untuk memprediksi kejadian yang akan terjadi dimasa depan berdasarkan data masa lalu. Dalam hal ini dilakukan peramalan penjualan kelapa di UKM Pak Balen Pasar Kandak Medan untuk membantu UKM tersebut memprediksi penjualan kelapa di tengah pendemi Covid 19. Peramalan dilakukan untuk memprediksi penjualan kelapa pada bulan Januari -Maret 2021. Selanjutnya, hasil peramalan yang diperoleh akan divalidasi dengan data aktual penjualan kelapa. Validasi ini bertujuan untuk mengetahui apakah metode peramalan yang digunakan sesuai untuk meramalkan penjualan di UKM Pak Balen Pasar Kandak Medan. Jika hasil peramalan dan validasi sesuai maka metode peramalan yang dipilih tepat untuk digunakan sebagai metode peramalan penjualan kelapa di UKM Pak Balen Pasar Kandak Medan.
Material and Metode. Metode peramalan yang digunakan untuk meramalkan penjualan kelapa di UKM Pak Balen Pasar Kandak Medan adalah metode ARIMA dan SARIMA. Kemudian dilakukan serangkaian uji untuk memilih metode yang tepat yang terdiri dari uji stasioneritas ragam, uji stasioneritas rata-rata, uji white noise, pemodelan sementara, dan uji signifikansi.
Hasil. Berdasarkan pengolahan data penjualan kelapa di UKM Pak Balen Pasar Kandak Medan diperoleh peramalan dengan metode ARIMA yang sesuai untuk meramalkan penjualan kelapa pada bulan Januari – Maret 2021 masing-masing adalah 520 kelapa, 486 kelapa, dan 459 kelapa. Sedangkan, metode SARIMA berdasarkan pengolahan data tidak memenuhi untuk peramalan, karena pada pengolah data uji signifikansi tidak terdapat model SARIMA yang signifikan.
Kesimpulan. Metode yang paling sesuai untuk meramalkan penjualan kelapa di UKM Pak Balen Pasar Kandak Medan adalah metode ARIMA dengan model (1, 1, 1). Dari validasi peramalan ARIMA dan penjualan aktual maka dapat disimpulkan bahwa metode ARIMA sesuai untuk meramalkan penjualan kelapa di UKM Pak Balen Pasar Kandak Medan. Karena hasil peramalan ARIMA mendekati data penjualan kelapa aktual pada bulan Januari – Maret 2021 yaitu masing-masing 572 kelapa, 490 kelapa, dan 451 kelapa.
Estrategias motivacionales para reforzar habilidades de emprendimiento
Authors: Jiménez Marjorie Magdalena Jara , Anchundia Liliana Isabel Flores , Ramos Victoria María Jiménez , Briones Maira Magdalena Delgado 
Published: December 2021

El presente trabajo de investigación se desarrolló teniendo como objetivo general proponer un manual de estrategias motivacionales para el fortalecimiento de las habilidades de emprendimiento de los estudiantes de bachillerato del Distrito 12D03 Mocache-Quevedo. La metodología se basó en un enfoque cuantitativo de tipo descriptivo proyectivo, con diseño de tipo no experimental, en donde se utilizó como técnica la entrevista, siendo el instrumento de recolección de datos el cuestionario, este estuvo dirigido a un grupo de estudio, integrado por 76 estudiantes, el mismo que estuvo constituido por 41 ítems, fue validado a través del juicio de expertos y la confiabilidad se realizó a través del coeficiente del Alfa de Cronbach, que arrojó un nivel de fiabilidad de 0,842. Los resultados permitieron conocer que los aspectos que debe contener un manual para reforzar las habilidades de emprendimiento deben estar relacionados con el auto concepto personal, auto estima y valoración a su capacidad, empatía ante situaciones adversas de sus pares y de ellos mismos, práctica de relaciones interpersonales, comunicación con sus pares, control de emociones ante discusiones y peleas entre compañeros, importancia del emprendimiento como alternativa laboral. En conclusión, se evidenció que es necesario el empleo de un manual de técnicas que permita el desarrollo de estrategias motivacionales para el fortalecimiento de las habilidades de emprendimiento de los estudiantes.
Assessment of Public Relations’ Practice of Edo State University Uzairue, Edo State, Nigeria
Authors: Chukwu Obinna Johnkennedy 
Published: December 2021

The study was carried out to assess public relations’ practice of Edo State University Uzairue. The study was predicated on Systems Theory (ST). The objectives were to determine the extent whether or not the Institution has a functional public relations department and to evaluate the extent of its public relations activities’ effectiveness, amongst others. Interview schedule was used to elicit information from the public relations office headed by the public relations officer. Findings indicates, amongst others, that the University has a public relations office, but does not have public relations department, and that the extent of her public relations activities’ effectiveness is average, amongst others. Given the above and the enormity of the importance of public relations to the educational institutions, the study, thus, recommend that Edo State University Uzairue should set-up a PR department with its ancillary compliments; step-up, and also, utilise effective public relations strategies in order to achieve effectiveness in its public relations’ campaigns or activities.
Integrating Indigenous Knowledge Systems in Entrepreneurship: A Case of Horticulture Farmers in Mutoko District of Zimbabwe
Authors: Mugambiwa Shingirai S. 
Published: December 2021

Entrepreneurship plays a significant role in eradicating poverty and providing sustainable livelihoods for communities. Governments, non-governmental organizations, and community development agencies are on the trail to consider rural entrepreneurship as an economic empowerment strategy in the developing world. Given the shortcomings of the Western entrepreneurship skills widely employed in many communities, this study assesses the role and significance of an approach that is place-based and rooted in local cultures that are associated with long-settled communities with strong ties to their natural environments. Nevertheless, a plethora of entrepreneurial strategies employed is foreign to local communities, which makes it difficult to produce the anticipated outcome vis-à-vis sustainable development. The study employs a qualitative method and an exploratory design. The findings of this research are based on in-depth interviews conducted among horticulture farmers in the Mutoko district. The significance of embracing Indigenous Knowledge Systems (IKS) in entrepreneurship among horticulture farmers in the Mutoko district was examined. Horticulture is a popular kind of farming in the region, with farmers specializing in tomatoes, cucumbers, leafy vegetables, onions, and butternut.
Investigation of the presence of OXA 48 and mcr-1 genes in carbapenem-resistant Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa strains by in house-PCR method
Authors: TARHAN Gülnur , ŞAHİN Funda , CESUR Salih 
Published: December 2021

Karbapenem dirençli Enterobacteriaceae (KRE)’nin neden olduğu enfeksiyonlar, küresel sağlık için ciddi bir sorundur. Karbapenemler, kapsamlı uygulamaları nedeniyle günümüzde direnç mekanizmaları gelişmiştir. Karbapenemaz sentezleyen izolatların saptanması, dağılımlarının takip edilmesi ve uygun tedavinin sağlanabilmesi açısından oldukça önemlidir. Günümüz ilaç direncinin saptanmasında Real-time-polimeraz zincir reaksiyonu (RT-PZR), başta olmak üzere çeşitli ticari moleküler tanı yöntemleri kullanılmaktadır. Ancak testlerin yapılabilmesi için pahalı ekipmanlara ihtiyaç duyulması nedeni ile, rutin bakteriyoloji laboratuvarlarında uygulanabilecek güvenilir, pratik ve düşük maliyetli testlere ihtiyaç duyulmaktadır.
Bu çalışma, Etlik İhtisas Eğitim ve Araştırma Hastanesi’nde çeşitli servislerde yatan hastalardan izole edilen genişlemiş spektrumlu beta-laktamaz (GSBL) pozitif, karbapenemlere dirençli dirençli, kolistine duyarlı toplam 60 Gram-negatif bakteri (39 suş Acinetobacter baumannii (A. baumannii), 11 suş Klebsiella pneumoniae (K. pneumoniae ve 10 suş Pseudomonas aeruginosa (P. aeruginosa))’de izolatın mcr-1 ve blaOXA-48 gen bölgelerinin varlığını belirlemek amacıyla yapılmıştır. Klinik örnekler konvansiyonel yöntemler ile izole edildikten sonra kesin tanımlama ve antibiyotik duyarlılık testleri otomatize sistemle çalışılmıştır. GSBL ve kolistin direncinin doğrulanması disk difüzyon testi ve gradyen testleri ile yapıldı. PZR sonuçlarına göre A. baumannii suşunun 10 tanesinde, K. pneumoniae suşunun bir tanesinde ve P. aeruginosa suşunun bir tanesinde mcr-1 geni saptandı. A. baumannii suşunun 5 tanesinde, K. pneumoniae suşunun 2 tanesinde blaOXA-48 geni saptandı. A. baumannii suşunun bir tanesinde her iki genin varlığı tespit edilmiştir. Sonuç olarak, karbapenemaz enzimi üretimi ve gen bölgesinin belirlenmesinde hızlı, tekrarlanabilir ve yüksek doğrulukta yeni tanı yöntemlerine ihtiyaç duyulmaktadır.
Sinovitli osteoartrit hastalarında herpes virüsler ve parvovirüs B19’a karşı oluşan antikor yanıtının serum ve sinoviyal sıvıda araştırılması
Authors: YILMAZ Neziha , ÖZTÜRK Reyhan , KORKMAZ Murat , KADER Çiğdem , BALCI Mehmet , KIZILKAYA Hafize , CESUR Salih , SABAH ÖZCAN Seda 
Published: December 2021

Amaç: Bu çalışmada diz ekleminde sinovit tanısı alan hastalarda, serum ve sinoviyal sıvıda sitomegalovirüs (CMV), Epstein-Barr virüsü (EBV), human herpes virüs-6 (HHV-6) ve parvovirüs B19’a karşı oluşan IgG yanıtlarının saptanması ve bu virüslere karşı oluşan spesifik lokal immun yanıtın, sinovit etiyolojisinin belirlenmesindeki rolünün araştırılması amaçlandı.
Gereç ve Yöntem: Çalışmaya Bozok Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Polikliniği’ne müracaat eden Kellgren Lawrence sınıflamasına göre evre 3 ve 4 osteoartrit ve sinoviti mevcut olan yetişkinler, hasta grubu olarak alındı. Benzer yaş grubunda, diz ağrısı nedeniyle veya başka bir nedenle diz grafisi çekilen ancak Kellgren Lawrence sınıflamasına göre diz osteoartriti olmayan hastalar kontrol grubu olarak seçildi. Hasta grubuna 29 sinovitli olan hasta alındı ve kontrol grubu olarak da 31 hasta çalışmamıza dahil edildi. Sinovitli hastalardan sinoviyal sıvı ve serum örnekleri alınırken kontrol grubundan sadece serum örnekleri alındı. Tüm örneklerde anti-CMV, EBV, HHV-6 ve parvovirus B19 IgG antikorları mikro ELISA yöntemiyle araştırıldı. Sinoviyal ya da lokal antikor üretimini belirlemek için hasta grubuna ait tüm örneklerde albumin düzeyi spektrofotometrik yöntemle saptandı ve sinoviyal antikor indeksi (sABI) hesaplandı. Hasta ve kontrol grubuna ait tüm örneklerde anti- CMV, EBV, HHV-6 ve parvovirüs B19 IgG pozitiflik oranı araştırıldı. Hasta grubunda serum ve sinoviyadaki IgG düzeyi ve sinoviyal antikor indeksi (sABI) karşılaştırıldı.
Bulgular: Tüm çalışma grubunda araştırılan virüsler için serumda IgG pozitifliği sırasıyla; CMV için %91, EBV için %85, parvovirus B19 için %36,6, HHV-6 içinse %43 olarak saptandı. Hasta serumlarında IgG poziflik oranı CMV ve EBV için en yüksekti ve sırasıyla; %100 ve 86 olarak saptandı. Kontrol grubunda EBV ve CMV IgG pozitiflik oranı %83 olarak saptandı. Hasta grubunda serumda parvovirus B19 ve HHV-6 IgG pozitiflik oranı ve absorbans değerleri kontrol grubuna göre daha yüksek saptandı. Hasta grubu serum ve sinoviyal antikor pozitifliği açısından karşılaştırıldığında; sinovitli olgularda lokal antikor üretiminin EBV IgG için %72,4 ile en fazla olduğu bunu %34,4 ile CMV IgG; % 27,5 ile parvovirus IgG ‘nin takip ettiği belirlendi.
Sonuç: Sinovitli hastalarda serumda anti- EBV IgG, anti- CMV IgG ve anti-parvovirüs B19 IgG pozitiflik oranları kontrol grubuna göre daha yüksek idi. Sinovitli hastalarda sinoviyal kültür örneklerinde etkenin saptanmadığı durumlarda; CMV, EBV, HHV-6 ve parvovirüs-B19 gibi virüslerin etken olabileceğinin akılda tutulmasının ve hastalarda serum antikorlarına ilaveten sinoviyal sıvıda lokal antikor yanıtlarının araştırılması için antikor indeksinin belirlenmesinin de yararlı olacağı görüşündeyiz.
Retrospective analysis of patients applying to a health board to determine disability rates
Authors: KAHYA Ismet Serhat , UYANER İlhan , KESKİN Abdullah , ŞAHİN Mustafa Engin , KAHYA Ibrahım Serdar , ÖZDİLEKCAN Çiğdem , ÖZDEMİR Tarkan 
Published: December 2021

Introduction: Disabled is defined as a person who loses their physical, mental, spiritual, emotional, and social abilities to various degrees, and who therefore has difficulty in adapting to social life and meeting daily needs. Our aim is to analyze those patients who applied to our hospital’s medical board due to disability and to contribute to the statistics available in this area.
Material and Method: Between 2015 and 2019, variables such as gender, age, disability rate, report duration, and additional diseases were analyzed among those patients who applied to Dr. Abdurrahman Yurtaslan Oncology Education and Research Hospital Health Board due to disability. Statistical Package for the Social Sciences (SPSS) version 21 (SPSS Inc., Chicago, IL, USA) was used for statistical analysis of the study data.
Results: Of the 2237 patients, 41.9% (n=938) were men and 58.1% (n=1299) were women. Patients’ mean age, regardless of gender, was found to be 55.29±16.32 years. Patients’ average disability score was 66.4±21.29; the three most common diseases were found to be cancer (n=1339, 28.19%), endocrinological and metabolic diseases (n=578, 12.16%), and cardiovascular system diseases (n=1056, 22.23%), respectively. Patients with a disability rate of 40% or above comprised 90% (n=2013) of the total number of patients; 5.1% (n=115) of the patients were fully dependent. Among all those who received reports, the rate of patients who received continuous reports was 71.9% (n=1610). The proportion of patients under 65 years of age (n=1598, 71.4%) was found to be higher than the proportion of patients above 65 years of age (n=636, 28.4%).
Conclusion: Hospital health boards play an important role in the detection and rating of disability. When we compared the data we obtained in our study with the literature, several differences could be found. It is thought that these differences may be related to hospital roles or differences in interpretation among the various health boards. For this reason, it is important to follow up whether the standards are applied as much as developing standards that will ensure unity in practice