bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Value of Preoperative Hematology Makers in the Classification and Molecular Subtypes of Newly Diagnosed High-Grade Gliomas
Authors: Jia Xin , Zhai Yixuan , Yang Fengdong , Wang Yiming , Wei Shuxin , Wei Xinting 
Published: June 2021

Abstract
Purpose: The purpose of our study is to explore the diagnostic value of the single and combined hematological maker for the classification and isocitrate dehydrogenase (IDH)-1/2 mutations (IDH) molecular subtypes of high-grade gliomas (HGGs).Methods: A total of 354 newly diagnosed HGGs patients were included in this study. Firstly, we compared the levels of hematology indicators in the classification and molecular subtypes of HGGs. Next, the correlation between the levels of hematology indicators with basic clinical features was analyzed. Finally, the diagnostic value of the single and combined hematology indicator for identifying the classification and molecular subtypes from HGGs was performed.Results: The level of fibrinogen (FIB) was higher in higher grade gliomas and glioblastoma multiforme IDH wild type (GBM IDH-wt). Nutrition-related indicators such as serum albumin (ALB), albumin/globulin ratio (AGR), and prognostic nutrition index (PNI) were negatively correlated with age, whereas FIB was positively associated with age. Compared with women, men with GBM had significantly higher AGR and lower serum globulin (GLOB). We found that the best single and combined indicator for identifying GBM and GBM IDH-wt from HGGs were FIB [0.595 (0.519-0.672) and 0.615 (0.546-0.684)] and age+FIB [0.712 (0.642-0.783) and 0.726 (0.662-0.791)], respectively.Conclusions: Preoperative hematological indicators have high diagnostic value for GBM and GBM IDH-wt from HGGs, especially FIB combined age.
Magnitude and Associated Factors of Depression Among People With Hypertension in Addis Ababa, Ethiopia: A Hospital Based Cross-Sectional Study
Authors: Asmare Yonatan , Ali Ahmed , Belachew Ayele 
Published: June 2021

Abstract
Background:The burden of depression is higher among people with chronic illnesses like hypertension and this comorbid condition leads to poor adherence to treatment and failure of compliance to lifestyle modifications, which in turn, increases risk of cardiovascular complications and mortalities. Low income countries, Ethiopia included, suffer from paucity of information describing the burden of hypertension comorbid with depression, which demands studies to narrow this knowledge gap, such as this one.Methods:Institution based cross-sectional study was conducted in three randomly selected public hospitals in Addis Ababa. Through a systematic random sampling method, a total of 416 known hypertensive patients with follow up in hypertension clinics with in the study period enrolled in the study. Data were collected through structured questionnaire administered by trained interviewer, which latter cleaned, edited and entered in to epi-data version 3.1. Descriptive and bi-variable and binary logistic regression analysis were done using the statistical software, SPSS version 25. Depression was assessed through Hospital Anxiety and Depression Scale (HADs).ResultsThe prevalence of depression among hypertensive patients was found to be 37.8%. The binary logistic regression model revealed that, female sex [AOR = 5.37, 95% CI (3.089–9.35)], being married [AOR = 0.25, 95% CI (0.08–0.78)], presence of chronic comorbid illnesses [AOR = 3.03, 95% CI (1.78–5.16)], uncontrolled blood pressure [AOR = 2.80, 95% CI (1.65–4.75)], duration of hypertension of 5–10 years [AOR = 3.17, 95% CI (1.61–6.23)] and more than 10 years [AOR = 5.81, 95% CI (2.90-11.65)], family history of depression [AOR = 4.53, 95% CI (2.37–8.66)] and current alcohol consumption [AOR = 1.77, 95% CI (1.02–3.07)] were significantly associated with depression among hypertensive patients.ConclusionHigher proportion of depression was observed among hypertensive patients, and socio-demographic, clinical and behavioral characteristics were found to significantly influence the likelihood of occurrence. Health care providers should consider mental health status of hypertensive patients, and counsel for these factors.
Eupafolin Induces Apoptosis and Autophagy of Breast Cancer Cells Through PI3K/AKT, MAPKs and NF-κB Signaling Pathways
Authors: Wei Jiahui , Ding Yu , Liu Xinmiao , Liu Qing , Lu Yiran , He Song , Yuan Bao , Zhang Jiabao 
Published: June 2021

Abstract
Eupafolin is a flavonoid that can be extracted from common sage. Previous studies have reported that Eupafolin has antioxidant, anti-inflammatory and anti-tumor properties. However, no studies have investigated the role of Eupafolin in breast cancer. Herein, we investigated the effect of Eupafolin on two human breast cancer cell lines, as well as its potential mechanism of action. Next, the data showed that proliferation, migration and invasion ability of breast cancer cells that were treated with Eupafolin was significantly reduced, while the apoptosis rate was significantly increased. In addition, Eupafolin treatment caused breast cancer cell proliferation to be blocked in the S phase. Moreover, Eupafolin significantly induced autophagy in breast cancer cells, with an increase in the expression of LC3B-II/I. PI3K/AKT, MAPKs and NF-κB pathways were significantly inhibited by Eupafolin treatment. Additionally, 3-MA (a blocker of autophagosome formation) significantly reduced Eupafolin-induced activation of LC3B-II/I in breast cancer cells. Furthermore, Eupafolin displayed good in vitro anti-angiogenic activity. Additionally, anti-breast cancer activity of Eupafolin was found to be partially mediated by Cav-1. Moreover, Eupafolin treatment significantly weakened carcinogenesis of MCF-7 cells in nude mice. Therefore, this data provides novel directions on the use of Eupafolin for treatment of breast cancer.
27 Al(d,alpha) and 27 Al(d,p) Nuclear Reaction Cross Sections at Ed&lt;2MeV Measured at Three Backward Scattering Angles Related to NRA
Authors: Salimi M. , Kakuee O. , Masoudi S. F. , kheiri H. R. , Briand E. , Ganem J-J. , Vickridge I. 
Published: June 2021

Abstract
The cross-sections of deuteron-induced nuclear reactions suitable for ion beam analysis, measured in different laboratories, are often significantly different. In the present work, differential cross-sections of 27 Al(d,p) and 27 Al(d,α) reactions were measured, and the cross sections benchmarked with thick target spectra obtained from pure aluminium for the first time in two independent laboratories. The 27 Al(d,p) and (d,alpha) differential cross-sections were measured between 1.4 and 2 MeV at scattering angles of 165°, 150°, and 135° in the VDGT laboratory in Tehran (Iran), and the same measurements for detector angle of 150° were repeated from scratch, including target making, with independent equipment on the SAFIR platform at INSP in Paris (France). The results of these two measurements at 150° are in good agreement, and for the first time a fitted function is proposed to describe the Al-cross sections for which no suitable theoretical expression exists. The obtained differential cross-sections were validated through benchmarking, by fitting with SIMNRA deuteron-induced particle spectra obtained from a high purity bulk Al target at both labs for deuteron incident energies between 1.6 and 2 MeV. The thick target spectra are well-reproduced. The evaluated and benchmarked cross sections have been uploaded to the ion beam analysis nuclear data library database (www-nds.iaea.org/ibandl/).
Tandem mass spectrometry-based identification of protein profiles in the cerebrospinal fluid of Alzheimer’s dementia patients
Authors: Misra Anamika , Chakrabarti Sankha Shubhra , Gambhir Indrajeet Singh , Baghel Meghraj Singh , Patil Yugendra Ramchandra 
Published: June 2021

Abstract
Background: Alzheimer’s disease (AD) is the most common form of dementia and about two thirds cases are diagnosed late due to a long asymptomatic phase. There exists the need for newer biomarkers which can add accuracy to AD diagnosis, detect AD at an early stage, as also lend new pathogenic insights into AD. Recent AD biomarker discovery has focused on proteomic approaches, especially in the cerebrospinal fluid. Methods: We used a bottom-up proteomic approach. Cerebrospinal fluid (CSF) samples from 6 patients with AD and 6 controls were digested with trypsin and analyzed by using LC-MS/MS (tandem mass spectrometry). The peptide data from CSF samples of both AD and control groups was then subjected to bioinformatics analysis with STRING version 11.0. Protein-protein interaction networks were constructed, and enrichment analysis performed.Results: Significant up-regulation of 13 proteins in the CSF was observed in AD cases in comparison to controls, while 30 proteins were down-regulated. APOE and LGALS3BP were the upregulated proteins involved in closed network and the downregulated proteins were F2, PENK, IGF2, APOH, SAA1, AHSG, SPP1 and CD44. APOE, APOH, F2 and PENK shared common involvement in multiple biological processes as evident on enrichment. Regulation of insulin like growth factor involving IGF2, F2, APOE and AHSG and glycosaminoglycan binding involving APOE, APOH, F2, SAA1, and CD44 were major pathways of interest determined on bioinformatic analysis.Conclusion: Our study identified novel tentative biomarkers of AD which included F2, PENK and SAA1, as well as reinforced earlier described biomarkers such as APOE and AHSG. These findings need to be validated in larger sample sizes to evaluate their utility as true biomarkers. Further, the pathways of interest- insulin like growth factor regulation and glycosaminoglycan binding need to be studied further in the context of AD.
Projections and management of the COVID-19 emergency in India
Authors: Michael Edwin , Newcomb Ken 
Published: June 2021

Abstract
The unfolding COVID-19 emergency in India not only points to the explosive speed with which SARS-CoV-2 can spread in populations if unchecked, but also to the gross misreading of the status of the pandemic when decisions to reopen the economy were made in March this year. In this modelling analysis, we isolate the population and policy-related factors underlying the current viral resurgence, and project the growth and magnitude of the health impact and demand for hospital care that may arise if immediate measures to contain the pandemic are not implemented. We indicate that only by re-introducing some measure of social mitigation alongside a swift ramping up of vaccinations will the country be able to contain and ultimately end the pandemic safely. Our results together with the scale of the virus resurgence reported in India also highlight the need for national decision-making that is driven primarily by scientific analysis and data.
The Impact of SARS-COV-2 Variants on Vaccine Efficacy Amongst Healthcare Workers During India’s Second Wave
Authors: Khawaja Tasveer , Jaswaney Rahul , Arora Nirav , Arora Shilpkumar , Gupta Anjan 
Published: June 2021

Abstract
Despite a growing sense of normalcy in many Western nations, another wave of the COVID-19 pandemic has spread rapidly through the Indian subcontinent.To improve our understanding of the crisis in India and the impact it is having on healthcare workers, we administered an electronic poll to healthcare workers in India.A total of 199 healthcare workers responded to the survey, the majority of whom were physicians. Of all respondents, 177 had received at least one dose of a COVID-19 vaccine. Of those vaccinated, 14 respondents (7.9%) received the Covaxin® (Bharat Biotech) vaccine, while the remaining 163 respondents (92.1%) received the Covishield® (Oxford-AstraZeneca) vaccine. Of the 177 respondents who received a dose of a COVID-19 vaccine, 76 (43%) acquired COVID-19 after vaccination, of which 88% had symptomatic infections. The protection offered by vaccination against new strains of SARS-CoV2 is a central question to which there remains an unclear answer.No external sources of funding were used.
A Novel 2D Graphene Oxide Modified α-AgVO3 Nanorods: Design, Fabrication and Enhanced Visible-Light Photocatalytic Performance
Authors: Xing Yan , WU Jian , MIN Xin , LI Xingao 
Published: June 2021

Abstract
Silver vanadates are promising visible-light-responded photocatalysts with suitable bandgap for solar absorption. However, the easy recombination of photogenerated carriers limits their performance. To overcome this obstacle, a novel 2D graphene oxide (GO) modified α-AgVO3 nanorods (GO/α-AgVO3) photocatalyst was designed herein to improve the separation of photocarriers. The GO/α-AgVO3 was fabricated through a facile in-suit coprecipitation method at room temperature. It was found that the as-prepared 0.5 wt.% GO/α-AgVO3 exhibited the most excellent performance for Rhodamine B (RhB) decomposition, with an apparent reaction rate constant 18 times higher than that of pure α-AgVO3 under visible-light irradiation. In light of the first-principles calculations and the heterojunction analysis, the mechanism underpinned the enhanced photocatalytic performance was proposed. The enhanced photocatalytic performance was ascribed to the appropriate bandgap of α-AgVO3 nanorods for visible light response and efficient separation of photocarriers through GO nanosheets. This work demonstrates the feasibility of overcoming the easy recombination of photogenerated carriers and provides a valuable GO/α-AgVO3 photocatalyst for pollutant degradation.
A Method for Quantifying Cervical Sagittal Morphology Using the Cervical Sagittal Triangle Area Coefficient
Authors: Guo Yingjun , Wang Han , Liu Hao , Wang Beiyu , Ding Chen , Meng Yang , Yang Yi 
Published: June 2021

Abstract
Background: A series of methods, which use angle to quantitatively evaluate cervical sagittal morphology cannot objectively reflect the advantages and disadvantages in some cases. In this study, we try to use the area methods to supplement it in above cases. Methods: The Cobb angle, range of motion (ROM) of C2-7, and antero-posterior diameter of atlas (C1-APD) were measured at neutral, flexion, and extension X-ray radiographs of the cervical spine in all 191 patients. Patients were divided into Group A and Group B according to whether their cervical sagittal morphology can be objectively quantified with Cobb angle. Pearson correlation analysis was used to compare the consistency of the results, paired t-test was used to compare the dispersion coefficient, receiver operator characteristic (ROC) curve was used to evaluate the diagnostic value.Results: The C5 vertebra was used as the vertex to construct the cervical sagittal triangle, and according to the different selection of the other two points, the triangle was further divided into four types. The Area Coefficient (AC) was defined as "B". In Group A, whose cervical sagittal morphology could be objectively quantified with Cobb angle, the AC showed greatly consistency, while in Group B, it was less consistent. AC results have stronger predictive value for clinical symptoms in Group B. The dispersion coefficients of the results measured by the four area methods are significantly smaller than the Cobb angle. The results of quantifying cervical ROM by area methods were also in good agreement with Cobb angle. Conclusion: Compared with Cobb angle, AC has better objectivity, stability, and clinical significance.
Indigenous Research Methodologies in Water Management: Learning From Australia and New Zealand for Application on Kamilaroi Country
Authors: Moggridge Bradley J , Thompson Ross M. , Radoll Peter 
Published: June 2021

Abstract
Indigenous Research Methodologies (IRMs) for considering cultural values of water are a missing component of water management in Australia. On this dry, flat and ancient continent Traditional Knowledge has been passed on from generation to generation for millennia. The profound knowledge of surface and groundwater has been critical to ensuring the survival of Indigenous peoples in a dry landscape, through finding, re-finding and protecting water. Indigenous Research Methodologies can provide a basis for the exploration of this knowledge in a way that that is culturally appropriate, and which generates a culturally safe space for Indigenous researchers and communities. The development of IRMs has occurred slowly in Australia over the past decades with the intention of shifting the research paradigm away from studying Indigenous peoples through non-Indigenous research methodologies, to partnering in developing methods appropriate to Indigenous knowledge systems. Indigenous Research Methodologies are rooted in Indigenous epistemologies and ontologies and represent a radical departure from more positivist forms of research (Wilson 2001). This allows the Indigenous researcher to derive the terms, questions and priorities of what is being researched, how the community is engaged, and how the research is delivered. Here, a brief overview is provided of Indigenous engagement in water management in Australia and Aotearoa or New Zealand, with reference to local case studies. These more general models are used as the basis for developing an IRM appropriate to the Kamilaroi people in the Gwydir Wetlands of northern NSW, Australia.
Over-expression of inositol 1,4,5-trisphosphate receptor type 3 in human endometrial cancer.
Authors: Mamoor Shahan 
Published: June 2021

Abstract
Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified inositol 1,4,5-trisphosphate receptor type 3, encoded by ITPR3, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ITPR3 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of ITPR3 was correlated with overall survival in white patients with low mutational burden. ITPR3 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.
Association between Adiponectin and Insulin Resistance among Sudanese Males with Type 2 Diabetes Mellitus
Authors: Almakey Eman Ahamed , Makeen Ahmed Mohamed , Saeed Osman Khalafalla , Mohamedahmed Khalid Abdelsamea 
Published: June 2021

Abstract
Background
Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increasing mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide.
Objectives
The aim of this study was to correlate serum levels of adiponectin with insulin resistance in Sudanese males' type 2 diabetes mellitus.
Methodology:
A case-control community-based study carried out among 126 patients with T2DM as cases group (mean ages 45.2 ± 5.4 years); and 126 normal healthy individuals as controls group (mean ages 44.7 ± 5.4 years as) in Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL of fasting venous blood was obtained from all participants. HbA1c, FPG, FPI, serum Adiponectin, and (HOMA)-IR were analyzed. SPSS (v 20.0) was used for data analysis.
Results
The mean of serum adiponectin in the cases group (3.03 ± 0.90µg/ml) was lower than the control group (6.02 ± 4.24µg/ml) giving highly significant differences -between them (P = value ≤ 0.000). HbA1c and Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) differed significantly between the two groups (P-value ≤ 0.000). Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002).
Conclusion
We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males.
The Messenger Matters:
Religious Leaders and Overcoming COVID-19 Vaccine Hesitancy
Authors: Viskupic Filip , Wiltse David 
Published: June 2021

Abstract
Experts agree that vaccination is the most effective way to bring the COVID-19 pandemic under control. Nevertheless, vaccination rates have slowed nationwide and large segments of the population report an unwillingness to get vaccinated. We conducted an online survey experiment to investigate if endorsement from various types of leaders can encourage the unvaccinated population to receive the vaccine. We surveyed 709 unvaccinated registered voters in South Dakota in April, 2021 and presented them with identical messages endorsing vaccination from a political, religious, or medical leader. Our results show that messaging from a religious leader has a positive and statistically significant effect on interest in getting vaccinated, while messages from a political or medical leader have no statistically significant effect. These results strongly suggest that religious leaders are more effective messengers than other potential messengers and that public health officials would be well served to coordinate their efforts with leaders in faith communities.
Translation of a circulating microRNA signature of melanoma into a solid tissue assay to improve diagnostic accuracy and precision.
Authors: Laar Ryan Van , King Samuel , McCoy Richard , Saad Mirette , Fereday Sian , Winship Ingrid , Uzzell Catherine , Landgren Anthony 
Published: June 2021

Abstract
Background: Successful treatment of cutaneous melanoma depends on early and accurate diagnosis of clinically suspicious melanocytic skin lesions. Multiple international studies have described the challenge of providing accurate and reproducible histopathological assessments of melanocytic lesions, highlighting the need for new diagnostic tools including disease-specific biomarkers. Previously, a 38-microRNA signature (“MEL38”) was identified in melanoma patient plasma and validated as a novel biomarker. In this study, MEL38 expression in solid tissue biopsies representing the benign naevi to metastatic melanoma spectrum is examined. Methods: Nanostring digital gene expression assessment of the MEL38 signature was performed on 308 formalin fixed paraffin embedded biopsies of naevi, melanoma in-situ and invasive melanoma. Genomic data were interrogated using hierarchical clustering, univariate, and multivariate statistical approaches. Classification scores computed from the MEL38 signature were analysed for their association with demographic data and histopathology results, including MPATH-DX class, AJCC disease stage and tissue subtype. Results: The MEL38 score can stratify higher-risk melanomas (MPATH-Dx Class V or more advanced) from lower-risk skin lesions (Class I-IV) with an area-under-the curve of 0.97 (P<0.001). The genomic score ranges from 0 to 10 and is positively correlated with melanoma progression, with an intraclass correlation coefficient of 0.85 with stage 0 to IV disease. Using an optimised classification threshold of ≥2.7 accurately identifies higher-risk melanomas, associated with poorer outcomes and more intensive suggested clinical actions with 89% sensitivity and 94% specificity. Multivariate analysis showed the score to be a significant predictor of malignancy, independent of technical and clinical covariates. Application of the MEL38 signature to spitz naevi reveal an intra-subtype profile, with elements of the profile in common to both naevi and melanoma. Conclusion: Melanoma-specific circulating microRNAs maintain their association with malignancy when measured in the hypothesized tissue of origin. The MEL38 signature is an accurate and reproducible metric of melanoma status, based on changes in microRNA expression that occur as the disease develops and spreads. Inclusion of the MEL38 score into routine practice would provide physicians with previously unavailable, personalised genomic information about their patient’s skin lesions. Combining molecular biomarker data with conventional histopathology data may improve diagnostic accuracy, healthcare resource utilisation, and patient outcomes.