bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Performa Website Universitas Teuku Umar Dan Universitas Samudera Menggunakan Pingdom Tools Dan Gtmetrix
Authors: Suliman  
Published: January 2021

Waktu loading dan kecepatan akses sebuah website memang perlu untuk diperhatikan, web developer sebisa mungkin harus berupaya untuk selalu meningkatkan kecepatan websitenya demi kenyamanan pengunjung. Terlebih dalam dunia pendidikan, website perguruan tinggi menjadi sangat penting mengingat kebutuhan mahasiswa dalam bertransaksi akademik. Maka dari itu performa website pada perguruan tinggi harus menjadi perhatian masing-masing perguruan tinggi dikarenakan salah satu peranan penting website dalam menunjang kegiatan akademiknya di perguruan tinggi. Evaluasi kualitas website dilakukan untuk mengetahui kualitas kecepatan performance website menggunakan Gtmetrix dan Pingdom Tools. Tujuan penelitian ini untuk mengetahui dan menyajikan perbandingan performa website Universitas Teuku Umar dan Universitas Samudera. Berdasarkan hasil pengujian website menggunakan Gtmatrix pada Universitas Teuku Umar diperoleh rata-rata Page Speed Score 27% atau di grade E. dan rata-rata YSlow Score 60% atau di grade D. Sedangkan hasil pengujian website Universitas Samudera diperoleh rata-rata Page Speed Score 54% atau di grade E. dan rata-rata YSlow Score 65% atau di grade D. Perbandingan pengukuran menggunakan Pingdom tools pada Universitas Teuku Umar hasil performance grade 69 atau di grade D dengan page size 29.0 MB sedangkan pada Universitas Samudera performance grade 67 atau di grade D dengan page size 5.0 MB.
PENGARUH PENGGUNAAN LISTRIK PASCABAYAR DAN TINGKAT PENJUALAN TERHADAP PIUTANG USAHA PADA PT. PLN (PERSERO) RAYON TANJUNG BATU
Authors: Ferawati Ferawati , Febri Susanto  , Fauzan Haqiqi  
Published: February 2021

Penelitian ini bertujuan untuk mengetahui pengaruh antara penggunaan listrik pascabayar dan tingkat penjualan terhadap piutang usaha secara parsial dan simultan pada PT. PLN (Persero) Rayon Tanjung Batu. Jenis penelitian ini bersifat kuantitatif dengan menggunakan data sekunder yang diperoleh dari laporan internal perusahaan. Teknik sampling yang digunakan adalah non-probability sampling yaitu teknik sampling dengan menggunakan pertimbangan khusus atau (purposive sampling) dengan menggunakan laporan yang diambil dari tahun 2014-2018. Dari pertimbangan dan kriteria yang disesuaikan untuk tujuan penelitian didapat sampel 24 sampel penelitian dengan rentang waktu 2 tahun (2016-2017).
Teknik analisa data yang digunakan dalam penelitian ini menggunakan metode verifikatif dengan pendekatan kuantitatif. Hasil uji t menunjukkan bahwa pascabayar berpengaruh terhadap piutang usaha dibuktikan dengan nilai t hitung sebesar 3.1088 lebih besar daripada t Tabel sebesar 2,07961 dan dengan tingkat sig 0.00 < (α) 0.05 (tingkat signifikan yang disyaratkan), hasil uji t menunjukkan bahwa tingkat penjualan tidak berpengaruh terhadap piutang usaha hal ini dibuktikan dengan nilai t hitung sebesar -1,10254 lebih kecil daripada t Tabel sebesar 2,07961 dan dengan tingkat sig 0.283 sig > (α) 0.05 (tingkat signifikan yang disyaratkan). Secara simultan pascabayar dan tingkat penjualan berpengaruh terhadap piutang usaha dibuktikan dengan nilai F hitung sebesar 5,858 lebih besar daripada F Tabel sebesar 3,47 dan dengan tingkat sig 0.00 yang berarti nilai sig < (α) 0.05 (tingkat signifikan yang disyaratkan).
Kata kunci : Penjualan, Listrik Pascabayar, dan Piutang usaha.
$d$-Minimal Surfaces in Three-Dimensional Singular Semi-Euclidean Space $\mathbb{R}^{0,2,1}$
Authors: Sato Yuichiro 
Published: January 2021

In this paper, we investigate surfaces in singular semi-Euclidean space $\mathbb{R}^{0,2,1}$ endowed with a degenerate metric. We define $d$-minimal surfaces, and give a representation formula of Weierstrass type. Moreover, we prove that $d$-minimal surfaces in $\mathbb{R}^{0,2,1}$ and spacelike flat zero mean curvature (ZMC) surfaces in four-dimensional Minkowski space $\mathbb{R}^{4}_{1}$ are in one-to-one correspondence.
Serum BDNF levels and the antidepressant effects of electroconvulsive therapy with ketamine anaesthesia: a preliminary study
Authors: Zheng Wei , Cen Qiaomei , Nie Sha , Li Minyi , Zeng Rong , Zhou Sumiao , Cai Dongbin , Jiang Miaoling , Huang Xiong 
Published: February 2021

Objective
To firstly examine the relationship between serum brain-derived neurotrophic factor (BDNF) levels and antidepressant response to ketamine as an anaesthesia in electroconvulsive therapy (ECT) in Chinese patients with treatment-refractory depression (TRD).

Methods
Thirty patients with TRD were enrolled and underwent eight ECT sessions with ketamine anaesthesia (0.8 mg/kg) alone. Depression severity, response and remission were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17). Enzyme-linked immunosorbent assay (ELISA) was applied to examine serum BDNF levels in patients with TRD at baseline and after the second, fourth and eighth ECT sessions. Baseline serum samples were also collected for 30 healthy controls.

Results
No significant differences were observed in serum BDNF levels between patients with TRD and healthy controls at baseline (p > 0.05). The remission rate was 76.7% (23/30) after the last ECT treatment, although all patients with TRD obtained antidepressant response criteria. Serum BDNF levels were not altered compared to baseline, even between remitters and nonremitters (all p > 0.05), despite the significant reduction in HAMD-17 and Brief Psychiatric Rating Scale (BPRS) scores after ECT with ketamine anaesthesia (all p < 0.05). The antidepressant effects of ECT with ketamine anaesthesia were not correlated with changes in serum BDNF levels (all p > 0.05).

Conclusion
This preliminary study indicated that serum BDNF levels do not appear to be a reliable biomarker to determine the antidepressant effects of ketamine as an anaesthesia in ECT for patients with TRD. Further studies with larger sample sizes are warranted to confirm these findings.
The fauna fights back: invasive Cane Toads killed by native centipedes in tropical Australia
Authors: Pomeroy John , Brown Gregory P. , Webb Grahame J. W. , Shine Richard 
Published: February 2021

ABSTRACT
We report two cases of Cane Toads Rhinella marina being killed by Australasian Giant Centipedes Ethmostigmus rubripes in the Northern Territory. At 1730 h on 12 November 2020, a centipede was found attacking a subadult Cane Toad near Larrimah, Northern Territory. At 2015 h on 26 April 2005, near Humpty Doo, a centipede that was seized by a subadult Cane Toad retaliated and killed its attacker (but did not consume it). These observations reinforce the fact that, contrary to popular opinion, Cane Toads are vulnerable to many species of native predators in Australia.
Health and Nutritional Qualities of Drinks Produced in the Beninese Brewery Company and Those Sold on the Benin Market
Authors: Tchekessi Célestin K. C. , Banon Jultesse S. B. , Fagbohoun Arthur , Aguenou Tchouaib , Bouraima Akim , Sachi Pivot S. A. , Bleoussi Roseline T. M. , Djogbe Anayce A. M. , Assogba Karl T. , Azokpota Paulin , Yaou Innocent P. Bokossa 
Published: February 2021

Aims: This study aims to evaluate the microbiological, physicochemical and sensory qualities of beverages sold on the market in Benin.
Study Design: The biological material used consisted mainly of beverage samples (126) collected at random from three wholesalers at the points of sale on two different occasions (regular period of 15 days) at the Dantokpa international market in Cotonou (Benin) in between April and September 2019.
Place and Duration of Study: This study was conducted between April and December 2019 at the Food Safety Research, Laboratory of Microbiology and Food Technologies, Department of Plant Biology, Faculty of Science and Technology, University of Abomey-Calavi, Benin.
Methodology: Microbiological, physicochemical and sensory qualities of samples were evaluated.
Results: The results of the microbiological analyzes revealed that all the drinks analyzed contained neither the total mesophilic aerobic flora, nor wild yeast, saccharomyces nor lactic bacteria. Therefore, the drinks are free from all pathogenic microorganisms that may harm the health of consumers. These products sold on the market complied with the criteria set by the standards and were therefore of satisfactory hygienic quality. However, the physicochemical parameters of the various drinks analyzed varied significantly from one brand to another. Results showed that the Nigerian Guinness produced contained more foam (287 s at 20 °C) and was rich in Diacetyl (0.119 mg / l) than the Benin Guinness (0.050 mg / l). As for the beer "La Béninoise", it produced more foam (220 s at 20 °C) than the Goldberg (209 s at 20 °C) but less than the Satzenbrau (250 s at 20 °C). The beer "La Béninoise" was less rich in Diacetyl (0.026 mg / l) and shown more than Goldberg (0.047 mg/l) and Satzenbrau (0.034 mg/l). As for the types of mixed drinks, it is the star Radler of Nigeria which presented a beautiful foam (235 s at 19.9 °C) with a cloudy aspect compared to the variegated one of Benin (227 s at 20.1 °C). Sensory analysis revealed that Beninese Brewery Company drinks were more appreciated by tasters.
Conclusion: In view of these results, all the beverages analyzed can be recommended to consumers because most of these drinks are of satisfactory quality and consistent with the standards.
Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge‐Associated Actinomycete Streptomyces diacarniLHW51701
Authors: Cheng Yijia , Chen Nannan , Li Jing , Su Jun‐Cheng , Yang Jingya , Zhang Cui‐Xian , Lin Hou‐Wen , Zhou Yongjun 
Published: January 2021

Main observation and conclusionFour new chlorinated carbazole alkaloids, chlocarbazomycins (CCBs) A—D, were isolated from sponge associated bacterium Streptomyces diacarni LHW51701. Their structures were elucidated via spectroscopic techniques (including HRESIMS, 1D & 2D NMR), and X‐ray crystallographic analysis. Structurally, the 4‐chloro coupled with 3‐methoxyl substituents in the tricycle nucleus of CCBs A—D and the N‐methoxyl group of CCB‐D are rare in naturally occurred tricyclic carbazole alkaloids. Moreover, CCBs A—D do not bear the typical C1 para‐alkyl and C2 meta‐methyl side chains of bacterial tricycle carbazoles, suggesting a novel mechanism of aromatic ring formation in biosynthesis. The biological evaluation showed that CCB‐C possessed inhibitory activities against pathogenic microorganisms including methicillin‐resistant Staphylococcus aureus (MRSA), Mycobacterium smegmatis, Bacillus mycoides, and Candida albicans.
A modified backward integration method for optimal control problems with degenerate equilibrium points
Authors: Fortuny Ayuso Pedro , Bayón Luis , Grau José María , Ruiz Maria del Mar , Suárez Pedro Maria 
Published: January 2021

AbstractWe present a new numerical indirect method to solve optimal control problems with degenerate equilibrium points. When the optimal control problem is autonomous, the corresponding canonical system becomes an autonomous system of ordinary differential equations. Combining the well‐known blow‐up technique of vector fields with the classic backward integration method, and focusing on a specific type of degenerate singular points, we develop a new method that is both easy to implement and able to deal with complex problems.
Exosome therapeutics for COVID‐19 and respiratory viruses
Authors: Popowski Kristen D. , Dinh Phuong‐Uyen C. , George Arianna , Lutz Halle , Cheng Ke 
Published: January 2021

AbstractRespiratory viral diseases are a leading cause of mortality in humans. They have proven to drive pandemic risk due to their complex transmission factors and viral evolution. However, the slow production of effective antiviral drugs and vaccines allows for outbreaks of these diseases, emphasizing a critical need for refined antiviral therapeutics. The delivery of exosomes, a naturally secreted extracellular vesicle, yields therapeutic effects for a variety of diseases, including viral infection. Exosomes and viruses utilize similar endosomal sorting pathways and mechanisms, providing exosomes with the potential to serve as a therapeutic that can target, bind, and suppress cellular uptake of various viruses including the novel severe acute respiratory syndrome coronavirus 2. Here, we review the relationship between exosomes and respiratory viruses, describe potential exosome therapeutics for viral infections, and summarize progress toward clinical translation for lung‐derived exosome therapeutics.
Respect for the journey: a survivor-led investigation of undergoing psychotherapy assessment
Authors: Faulkner Alison , Kelly Katie , Gibson Sarah , Gillard Steve , Samuels Lana , Sweeney Angela 
Published: January 2021

Abstract
Purpose
Psychotherapy assessments are key decision points for both clients and services, carrying considerable weight on both sides. Limited research indicates that assessments have immediate and long-term impacts on clients, particularly where trauma has been experienced, affecting engagement with therapy. Understanding assessments from clients’ perspectives can inform service development and improve client experience.

Methods
This is a survivor-led exploration of clients’ experiences of undergoing assessment for talking therapies. Interviews were conducted with seven people who had undergone assessment for psychological therapies in third sector and NHS services. Interviews were recorded, transcribed and analysed thematically.

Results
The core theme was ‘respect for the journey’ reflecting the need expressed by participants for their life experiences prior to the assessment to be given full respect and consideration. Six sub-themes were identified: trauma and desperation, fear of judgement, search for trust and safety, sharing and withholding (a balancing act), feeling deconstructed, and finding hope.

Conclusions
The findings highlight the heightened emotional power surrounding psychotherapy assessments, reflecting the journey participants had undertaken to reach this point. The dilemma facing clients at the heart of an assessment—how much to share and how much to withhold—demonstrates the importance for services and assessors of treating the journey a client has made to the assessment with care and respect. Findings indicate the value of services and practitioners undertaking a trauma-informed approach to assessment encounters.
A high tibial slope, allograft use, and poor patient-reported outcome scores are associated with multiple ACL graft failures
Authors: Winkler Philipp W. , Wagala Nyaluma N. , Hughes Jonathan D. , Lesniak Bryson P. , Musahl Volker 
Published: January 2021

Abstract
Purpose
To compare clinical outcomes, radiographic characteristics, and surgical factors between patients with single and multiple anterior cruciate ligament (ACL) graft failures. It was hypothesized that patients experiencing multiple ACL graft failures exhibit lower patient-reported outcome scores (PROs) and a higher (steeper) posterior tibial slope (PTS) than patients with single ACL graft failure.

Methods
Patients undergoing revision ACL reconstruction with a minimum follow-up of 12 months were included in this retrospective cohort study. Based on the number of ACL graft failures, patients were assigned either to the group “single ACL graft failure “or” multiple ACL graft failures “. The PTS was measured on strict lateral radiographs. Validated PROs including the International Knee Documentation Committee (IKDC) subjective knee form, Knee Injury and Osteoarthritis Outcome Score, Lysholm Score, Tegner Activity Scale, ACL-Return to Sport after Injury Scale, and Visual Analogue Scale for pain were collected.

Results
Overall, 102 patients were included with 58 patients assigned to the single ACL graft failure group and 44 patients to the multiple ACL graft failures group. Quadriceps tendon autograft was used significantly more often (55% vs. 11%, p < 0.001) and allografts were used significantly less often (31% vs. 66%, p < 0.001) as the graft for first revision ACL reconstruction in patients with single versus multiple ACL graft failures. Patients with multiple ACL graft failures were associated with statistically significantly worse PROs (IKDC: 61.7 ± 19.3 vs. 77.4 ± 16.8, p < 0.05; Tegner Activity Scale: 4 (range, 0–7) vs. 6 (range 2–10), p < 0.05), higher PTS (12 ± 3° vs. 9 ± 3°, p < 0.001), and higher rates of subsequent surgery (73% vs. 14%, p < 0.001) and complications (45% vs. 17%, p < 0.05) than patients with single ACL graft failure.

Conclusion
Compared to single ACL graft failure in this study multiple ACL graft failures were associated with worse PROs, higher PTS, and allograft use. During the first revision ACL reconstruction, it is recommended to avoid the use of allografts and to consider slope-reducing osteotomies to avoid multiple ACL graft failures and improve PROs.

Level of evidence
Level 3.
Harmonisation of PET/CT contrast recovery performance for brain studies
Authors: Verwer E. E. , Golla S. S. V. , Kaalep A. , Lubberink M. , van Velden F. H. P. , Bettinardi V. , Yaqub M. , Sera T. , Rijnsdorp S. , Lammertsma A. A. , Boellaard R. 
Published: January 2021

Abstract
Purpose
In order to achieve comparability of image quality, harmonisation of PET system performance is imperative. In this study, prototype harmonisation criteria for PET brain studies were developed.

Methods
Twelve clinical PET/CT systems (4 GE, 4 Philips, 4 Siemens, including SiPM-based “digital” systems) were used to acquire 30-min PET scans of a Hoffman 3D Brain phantom filled with ~ 33 kBq·mL−1 [18F]FDG. Scan data were reconstructed using various reconstruction settings. The images were rigidly coregistered to a template (voxel size 1.17 × 1.17 × 2.00 mm3) onto which several volumes of interest (VOIs) were defined. Recovery coefficients (RC) and grey matter to white matter ratios (GMWMr) were derived for eroded (denoted in the text by subscript e) and non-eroded grey (GM) and white (WM) matter VOIs as well as a mid-phantom cold spot (VOIcold) and VOIs from the Hammers atlas. In addition, left-right hemisphere differences and voxel-by-voxel differences compared to a reference image were assessed.

Results
Systematic differences were observed for reconstructions with and without point-spread-function modelling (PSFON and PSFOFF, respectively). Normalising to image-derived activity, upper and lower limits ensuring image comparability were as follows: for PSFON, RCGMe = [0.97–1.01] and GMWMre = [3.51–3.91] for eroded VOI and RCGM = [0.78–0.83] and GMWMr = [1.77–2.06] for non-eroded VOI, and for PSFOFF, RCGMe = [0.92–0.99] and GMWMre = [3.14–3.68] for eroded VOI and RCGM = [0.75–0.81] and GMWMr = [1.72–1.95] for non-eroded VOI.

Conclusions
To achieve inter-scanner comparability, we propose selecting reconstruction settings based on RCGMe and GMWMre as specified in “Results”. These proposed standards should be tested prospectively to validate and/or refine the harmonisation criteria.
Assessment of Surgical Care Provided in National Health Services Hospitals in Mozambique: The Importance of Subnational Metrics in Global Surgery
Authors: Cossa Matchecane , Rose John , Berndtson Allison E. , Noormahomed Emilia , Bickler Stephen W. 
Published: January 2021

AbstractIntroductionSurgery plays a critical role in sustainable healthcare systems. Validated metrics exist to guide implementation of surgical services, but low‐income countries (LIC) struggle to report recommended metrics and this poses a critical barrier to addressing unmet need. We present a comprehensive national sample of surgical encounters from a LIC by assessing the National Health Services of Mozambique.Material and methodsA prospective cohort of all surgical encounters from Mozambique's National Health Service was gathered for all provinces between July and December 2015. Primary outcomes were timely access, provider densities for surgery, anesthesiology, and obstetrics (SAO) per 100,000 population, annualized surgical procedure volume per 100,000, and postoperative mortality (POMR). Secondary outcomes include operating room density and efficiency.ResultsFifty‐four hospitals had surgical capacity in 11 provinces with 47,189 surgeries. 44.9% of Mozambique's population lives in Districts without access to surgical services. National SAO density was 1.2/100,000, ranging from 0.4/100,000 in Manica Province to 9.8/100,000 in Maputo City. Annualized national surgical case volume was 367 procedures/100,000 population, ranging from 180/100,000 in Zambezia Province to 1,897/100,000 in Maputo City. National POMR was 0.74% and ranged from 0.23% in Maputo Province to 1.78% in Niassa Province.DiscussionSurgical delivery in Mozambique falls short of international targets. Subnational deficiencies and variations between provinces pose targets for quality improvement in advancing national surgical plans. This serves as a template for LICs to follow in gathering surgical metrics for the WHO and the World Bank and offers short‐ and long‐term targets for surgery as a component of health systems strengthening.
Outcomes of Incisional Hernia Repair Surgery After Multiple Re‐recurrences: A Propensity Score Matched Analysis
Authors: Sneiders Dimitri , de Smet Gijs H. J. , Hartog Floris den , Yurtkap Yagmur , Menon Anand G. , Jeekel Johannes , Kleinrensink Gert‐Jan , Lange Johan F. , Gillion Jean‐François 
Published: January 2021

AbstractBackgroundPatients with a re‐recurrent hernia may account for up to 20% of all incisional hernia (IH) patients. IH repair in this population may be complex due to an altered anatomical and biological situation as a result of previous procedures and outcomes of IH repair in this population have not been thoroughly assessed. This study aims to assess outcomes of IH repair by dedicated hernia surgeons in patients who have already had two or more re‐recurrences.MethodsA propensity score matched analysis was performed using a registry‐based, prospective cohort. Patients who underwent IH repair after ≥ 2 re‐recurrences operated between 2011 and 2018 and who fulfilled 1 year follow‐up visit were included. Patients with similar follow‐up who underwent primary IH repair were propensity score matched (1:3) and served as control group. Patient baseline characteristics, surgical and functional outcomes were analyzed and compared between both groups.ResultsSeventy‐three patients operated on after ≥ 2 IH re‐recurrences were matched to 219 patients undergoing primary IH repair. After propensity score matching, no significant differences in patient baseline characteristics were present between groups. The incidence of re‐recurrence was similar between groups (≥ 2 re‐recurrences: 25% versus control 24%, p = 0.811). The incidence of complications, as well as long‐term pain, was similar between both groups.ConclusionIH repair in patients who have experienced multiple re‐recurrences results in outcomes comparable to patients operated for a primary IH with a similar risk profile. Further surgery in patients who have already experienced multiple hernia re‐recurrences is justifiable when performed by a dedicated hernia surgeon.