bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart Rate Variability Analysis in Episodic Migraine: A Cross-Sectional Study
Authors: Zhang Lvming , Qiu Shi , Zhao Chunxia , Wang Peifu , Yu Shengyuan 
Published: March 2021

Objective: It has been reported that autonomic nervous dysfunction is more prevalent in migraineurs. Heart rate variability (HRV) is a commonly used method to evaluate the cardiac autonomic nervous function modulation. However, HRV changes in migraine are still contradictory. The main objective of this study was to explore the potential HRV change patterns in episodic migraine (EM) and whether there were differences in HRV between EM ictal period and the interictal period.Patients and Methods: We conducted a cross-sectional study including 18 patients with EM and 18 age- and sex-matched controls. The characteristics of demographics, some lifestyle factors, and psychological conditions were assessed at baseline. HRVs including time-domain analysis and frequency-domain analysis were performed in all participants. HRV analyses in migraine were recorded not only in the interictal period but also in the ictal period.Results: All the HRV parameters showed a decreased trend in migraine than controls. Time-domain parameters standard deviation of all NN intervals in 24 h (SDNN) and triangular index were significantly lower in the migraine ictal period than controls separately (SDNN, 56.94 ± 22.09 ± 7.76 vs. 135.78 ± 35.16, p &lt; 0.001; triangular index, 12.61 ± 3.20 vs. 22.11 ± 6.90, p &lt; 0.001). Frequency-domain parameter low-frequency power was also lower in the migraine ictal period than controls (351.28 ± 206.71 vs. 559.61 ± 281.24, p = 0.02). SDNN was much lower in the migraine ictal period than migraine interictal period (56.94 ± 22.09 vs. 115.94 ± 46.88, p &lt; 0.001). HRV changes during migraine interictal period did not differ from the control group. The correlation analysis revealed a negative correlation between visual analog scale and HRV parameters in the migraine ictal period (p = 0.04).Conclusions: The present cross-sectional study indicates that HRV was significantly decreased in EM population especially during the migraine ictal period, which means unbalance of autonomic system in EM. Perhaps larger prospective cohort studies are wanted to validate these findings.
Morphological Changes in Cortical and Subcortical Structures in Multiple System Atrophy Patients With Mild Cognitive Impairment
Authors: Cao Chenghao , Wang Qi , Yu Hongmei , Yang Huaguang , Li Yingmei , Guo Miaoran , Huo Huaibi , Fan Guoguang 
Published: March 2021

ObjectiveThis study aimed to investigate the morphometric alterations in the cortical and subcortical structures in multiple system atrophy (MSA) patients with mild cognitive impairment (MCI), and to explore the association with cognitive deficits.MethodsA total of 45 MSA patients (25 MSA-only, 20 MSA-MCI) and 29 healthy controls were recruited. FreeSurfer software was used to analyze cortical thickness, and voxel-based morphometry was used to analyze the gray matter volumes. Cortical thickness and gray matter volume changes were correlated with cognitive scores.ResultsCompared to healthy controls, both MSA subgroups exhibited widespread morphology alterations of brain structures in the fronto-temporal regions. Direct comparison of MSA-MCI and MSA-only patients showed volume reduction in the left superior and middle temporal gyrus, while cortical thinning was found in the left middle and inferior temporal gyrus in MSA-MCI patients. Cortical thinning in the left middle temporal gyrus correlated with cognitive assessment and disease duration.ConclusionStructural changes in the brain occur in MSA-MCI patients. The alteration of brain structure in the left temporal regions might be a biomarker of cognitive decline in MSA-MCI patients.
Demethylated miR-216a Regulates High Mobility Group Box 3 Promoting Growth of Esophageal Cancer Cells Through Wnt/β-Catenin Pathway
Authors: Sun Cheng-Xi , Zhu Feng , Qi Lei 
Published: March 2021

BackgroundEsophageal cancer (EC) is the eighth most common cause of cancer-associated mortality in humans. Recent studies have revealed the important roles of microRNAs (miRs) in mediating tumor initiation and progression. miR-216a has been found to be involved in the progression of EC, but the underlying mechanisms remain largely unknown. The aim of this study is to explore the mechanism of miR-216a and the downstream molecules in esophageal cancer.Materials and MethodsThe degree of methylation of miR-216a promoter in EC tissues and cell lines was determined with methylation specific polymerase chain reaction (MSP). The levels of miR-216a and HMGB3 in EC cells were quantified by quantitative PCR (qPCR) and Western blot (WB). EC cell lines were treated with DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-AZ), miR-216a mimics, and HMGB3 siRNA to explore the effects of miR-216a and HMGB3 on the proliferation, migration, invasion, and apoptosis of cells. Dual-luciferase reporter assay was employed to verify the binding of miR-216a to the 3’UTR of HMGB2 mRNA.ResultsThe promoter of MiR-216a was hypermethylated and the expression of miR-216a was down-regulated in EC, while HMGB3 was up-regulated. Dual luciferase reporter assay confirmed the binding of miR-216a to the 3’UTR of HMGB3 mRNA. Demethylated miR-216a and miR-216a mimics elevated miR-216a expression and down-regulated HMGB3, as well as inhibited cell proliferation, migration, and invasion. Inhibiting the expression of HMGB3 played an important role in inducing apoptosis, suppressing cell expansion, and down-regulating the activity of Wnt/β-catenin pathway.ConclusionsHypermethylation in the promoter of miR-216a upregulated HMGB3 and the Wnt/β-catenin pathway, resulting in enhanced EC progression.
Individualized 3D-Printed Tissue Retraction Devices for Head and Neck Radiotherapy
Authors: Herpel Christopher , Schwindling Franz Sebastian , Held Thomas , Christ Leo , Lang Kristin , Schwindling Martha , Moratin Julius , Zaoui Karim , Moutsis Tracy , Plinkert Peter , Herfarth Klaus , Freudlsperger Christian , Rammelsberg Peter , Debus Jürgen , Adeberg Sebastian 
Published: March 2021

BackgroundRadiotherapy for head and neck cancer may cause various oral sequelae, such as radiation-induced mucositis. To protect healthy tissue from irradiation, intraoral devices can be used. Current tissue retraction devices (TRDs) have to be either individually manufactured at considerable cost and time expenditure or they are limited in their variability. In this context, a 3D-printed, tooth-borne TRD might further facilitate clinical use.MethodsA novel approach for the manufacturing of TRDs is described and its clinical application is analysed retrospectively. The devices were virtually designed for fabrication by 3D-printing technology, enabling—in only a single printing design—caudal or bi-lateral tongue displacement, as well as stabilization of a tongue-out position. For a total of 10 patients undergoing radiotherapy of head and neck tumors, the devices were individually adapted after pre-fabrication. Technical and clinical feasibility was assessed along with patient adherence. Tissue spacing was calculated by volumetric analysis of tongue retraction. In one exemplary case, radiotherapy treatment plans before and after tissue displacement were generated and compared. The reproducibility of maxillomandibular relation at device re-positioning was quantified by repeated intraoral optical scanning in a voluntary participant.Results3D-printing was useful for the simplification of TRD manufacture, resulting in a total patient treatment time of less than 30 min. The devices were tolerated well by all tested patients over the entire radiation treatment period. No technical complications occurred with the devices. The TRDs caused an effective spacing of the healthy adjacent tissue, e.g., the tongue. Position changes of maxillomandibular relation were limited to a mean value of 98.1 µm ± 29.4 µm root mean square deviation between initial reference and follow-up positions.ConclusionsThe presented method allows a resource-efficient fabrication of individualized, tooth-bourne TRDs. A high reproducibility of maxillomandibular relation was found and the first clinical experiences underline the high potential of such devices for radiotherapy in the head and neck area.
Gastrointestinal Metastases From Primary Renal Cell Cancer: A Single Center Review
Authors: Rony Maelle , Ratone Jean-Philippe , Walz Jochen , Pignot Geraldine , Caillol Fabrice , Pesenti Christian , Guerin Mathilde , Dermeche Slimane , Brunelle Serge , Salem Naji , Vicier Cecile , Rybikowski Stanislas , Maubon Thomas , Fakhfakh Sami , Tejeda Manuel , Giovannini Marc , Gravis Gwenaelle 
Published: March 2021

Introduction: Digestive metastases (DMs) from renal cell cancer (RCC) are rare. Over the past decade, the overall survival of metastatic RCC (mRCC) has been improved by tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors. The main objective of this study was to assess the incidence of metastases of the digestive tract in this new field of treatment. The secondary objectives were to evaluate the clinical characteristics, prognosis, treatments used for DMs, and median time between the diagnosis of RCC or mRCC and DMs.Materials and Methods: A retrospective analysis of data collected from all patients with mRCC between 2007 (the time of TKI was a standard of care) and 2019 was carried out at the Paoli-Calmettes Institute (Marseille, France). Computer research software using artificial intelligence (ConSoRe®) was used to identify patients and assess their characteristics.Results: Between January 2007 and December 2019, 11 out of 660 (1.6%) mRCC patients had metastases of the gastrointestinal tract. The median age was 62 years. Of the 11 patients, 81.8% experienced digestive bleeding or anemia. Only 2 patients were asymptomatic. The metastases were mainly duodenal (50%) and gastric (41.6%). The median time from cancer diagnosis and from metastatic disease to gastrointestinal metastasis was 4.3 years (3 months−19.2 years) and 2.25 years (0 days−10.2 years), respectively. Local treatment was performed in 38.5% of cases by endoscopy (60%), surgery (20%) and radiotherapy (40%) with success rates of 33, 100, and 50%, respectively. Etiological treatment was modified following the discovery of DM in 84.6% of the cases. The median survival was 1 year from the diagnosis of DM (13 days−9.4 years). Two patients were still alive 2.9 and 9.4 years after the diagnosis of DM.Conclusion: This is the largest monocentric retrospective analysis of DM in patients with RCC. It seems to be a rare and late event in the course of the disease. Local treatment combined with systemic treatment could improve survival. In the context of prolonged survival with the new based immunotherapy treatments in mRCC, we suggest that unexplained anemia or persistent digestive symptoms could be explored by endoscopy.
A Multi-Faceted Strategy for Evidence Translation Reduces Healthcare Waiting Time: A Mixed Methods Study Using the RE-AIM Framework
Authors: Harding Katherine E. , Lewis Annie K. , Snowdon David A. , Kent Bridie , Taylor Nicholas F. 
Published: March 2021

Background: Waiting lists are often thought to be inevitable in healthcare, but strategies that address patient flow by reducing complexity, combining triage with initial management, and/or actively managing the relationship between supply and demand can work. One such model, Specific Timely Appointments for Triage (STAT), brings these elements together and has been found in multiple trials to reduce waiting times by 30–40%. The next challenge is to translate this knowledge into practice.Method: A multi-faceted knowledge translation strategy, including workshops, resources, dissemination of research findings and a community of practice (CoP) was implemented. A mixed methods evaluation of the strategy was conducted based on the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, drawing on an internal database and a survey of workshop and CoP participants.Results: Demonstrating reach, at July 2020 an internal database held details of 342 clinicians and managers from 64 health services who had participated in the workshop program (n = 308) and/or elected to join an online CoP (n = 227). 40 of 69 (58%) respondents to a survey of this population reported they had adopted the model, with some providing data demonstrating that the STAT model had been efficacious in reducing waiting time. Perceived barriers to implementation included an overwhelming existing waiting list, an imbalance between supply and demand and lack of resources.Conclusion: There is high quality evidence from trials that STAT reduces waiting time. Using the RE-AIM framework, this evaluation of a translation strategy demonstrates uptake of evidence to reduce waiting time in health services.
La Alhambra interpretada: entre la poscolonialidad y la descolonización del imaginario
Authors: González Alcantud José Antonio 
Published: March 2021

La Alhambra, antiguo monumento islámico levantado entre los siglos xiii y xv en la ciudad andaluza de Granada para albergar a la corte real nazarí, ha sido privilegiado objeto de reflexión desde finales del siglo xviii para los orientalistas. Este artículo propone una lectura poscolonial y posmoderna consecuente de la Alhambra con el fin de superar precisamente el horizonte orientalista fijado de manera estereotípica sobre todo por los viajeros románticos. Para ello introduce al lector en qué significa el discurso poscolonial, y cómo la obra del arabista británico Robert Irwin, responde a esa lógica posmoderna. Se finaliza criticando la posición de éste por inconsecuentemente poscolonial al sostenerse en una jerarquía lingüística, donde la lengua inglesa tiene un lugar privilegiado, al haberse abandonado las fuentes del conocimiento locales simplemente por no expresarse en los circuitos académicos anglosajones.
L’imaginaire du Phénix dans La Pente, Les Crépuscules de Z. Morsy. En attente de la révolution solaire
Authors: Fintz Claude 
Published: March 2021

Notre analyse a pour objectif de souligner l’existence d’un rayonnement ombreux du mythe du Phénix, plus puissant que l’actualisation de mythèmes académiquement répertoriés. Nous mettrons en lumière son étonnante vivacité et son impressionnante capacité d’adaptation — mais aussi la profonde originalité de la poétique de Morsy. Mêlant en effet dénonciation et incertitude, révolte et espérance, apocalypse et renaissance, elle indique une aspiration à renverser un ordre établi. Poésie et mythe, à partir d’une réflexion polémique sur l’histoire, ont retrouvé ici leur commune origine. En dépit de ses nombreuses ambiguïtés, le Phénix structure l’imaginaire crépusculaire du recueil : il est avant tout puissance de transgression, source secrète de sa poétique.
Les figures de proue zoomorphes dans l’iconographie médiévale chrétienne : rhétorique de l’Incarnation
Authors: Auger Barbara 
Published: March 2021

S’interroger sur la présence des figures de proue zoomorphes dans l’image chrétienne, c’est poser les questions du discours symbolique mis en place, de la typologie de ses signes et de l’intentionnalité signifiante de l’auteur. Aussi cet article propose-t-il dans un premier temps de dévoiler, par le biais d’un examen terminologique, le processus cognitif déterminant les notions culturelles de « figure » et de « navire », avant d’analyser, dans un second temps, l’iconicité qui leur est rattachée. Est ainsi démontré que, sur la base d’une dialectique latine et du remploi de formes antiques, la figure de proue participe d’une rhétorique fondamentale de la spiritualité chrétienne : la multiplication et démonstration du mystère de l’Incarnation.
Applying Ibn Khaldūn
Authors: Mohamed Yasien 
Published: March 2021

The intellectual legacy of Ibn Khaldūn is unique among Muslim historians, and yet he is not fully appreciated in the East. Many Muslim scholars—including Muhammad Abdullah Enan, Muhsin Mahdi, and Mahmoud Dhaoudi—have written about Ibn Khaldūn in English. Their treatment of him was either comparative or historical, but none presented his theory as a valid framework for sociological analysis today as Syed Farid Alatas does in his Applying Ibn Khaldūn.
Pendapatan Asli Daerah, Pendapatan Transfer, Penerimaan Pembiayaan Dan Realisasi Belanja Modal Provinsi Bengkulu
Authors: Endah Rahmadewi Diana 
Published: March 2021

ABSTRACT
Capital expenditure is very important role in the region, with capital expenditures, the region will be grow and capable increase investment. The purpose of this study to prove that the Regionally Original Income, Funds Transfer consisting of General Allocation Fund, Special Allocation Fund and Revenue fund, Other Income, Receipt Financing influence simultaneously and partially on capital expenditures. The sample used is the Government/City District in Bengkulu of 60 District/City from 2008-2013. The analysis tool to test the hypothesis is multiple linear regression. The results showed that in partial regionally original Income, special allocation fund, other income and receipt financing are positive effect on capital expenditures, variable general allocation fund negative effect on capital expenditures, variable revenue fund no effect on capital expenditures. Simultaneously regionally original Income, general allocation fund, special allocation fund, revenue fund, Other Income and Receipt Financing positive significant effect on capital expenditures.
ABSTRAK
Peran Belanja Modal sangat penting di daerah, dengan belanja modal mampu membuat daerah menjadi berkembang sehingga diharapkan mampu meningkat pertumbuhan investasi di daerah tersebut. Tujuan penelitian ini untuk membuktikan bahwa Pendapatan Asli Daerah, Dana Transfer yang terdiri dari Dana Alokasi Umum, Dana Alokasi Khusus dan Dana Bagi Hasil, Pendapatan Lain Lain yang sah, Penerimaan Pembiayaan berpengaruh secara simultan dan parsial terhadap realisasi belanja modal. Sampel yang digunakan adalah 60 Kabupaten /Kota di Bengkulu dari tahun 2008-2013. Alat analisis untuk menguji hipotesis adalah regresi linier. Hasil penelitian menunjukkan bahwa secara parsial variabel Pendapatan Asli Daerah, Dana Alokasi Khusus, pendapatan lain lain yang sah, penerimaan pembiayaan berpengaruh positif terhadap realisasi belanja modal, variabel Dana Alokasi Umum berpengaruh negative terhadap realisasi belanja modal, variabel Dana Bagi Hasil tidak berpengaruh terhadap realisasi belanja modal. Secara simultan Pendapatan Asli Daerah, Dana Alokasi Umum, Dana Bagi Hasil, Dana Alokasi Khusus, Pendapatan Lain lain yang sah dan Penerimaan Pembiayaan berpengaruh signifikan positif terhadap realisasi belanja modal.
JEL Classification: M41, M42
Determinan Pertumbuhan Laba Perusahaan Manufaktur Di Bursa Efek Indonesia
Authors: Megasari AWS Rinzany , Surtikanti Surtikanti , Darmansyah Darmansyah 
Published: March 2021

ABSTRACT
Profit growth is a ratio that indicates a company›s ability to increase net income over the previous year. The higher the profit growth ratio, the better the financial performance of an enterprise. This study aims to examine the influence of current ratio, debt to asset ratio, total asset turnover, and net profit margin on profit growth of consumer goods manufacturing sector in Indonesia Stock Exchange Year 2011-2015. The sample technique used in this research is purposive sampling. There are 21 companies used during the research. The analysis technique used in this research is panel data regression analysis using EViews 10. The sample data is tested by using hypothesis test done by using R², F test, and T test.The results of this study indicate that partially current ratio (CR), and debt to asset ratio (DER) have significant and negative effect, Total Asset Turnover (TAT) has a significant positive effect while Net Profit Margin (NPM) has no significant and positive effect on profit growth Manufacturing of industrial goods sector in Indonesia Stock Exchange Year 2011-2015.
ABSTRAK
Pertumbuhan laba adalah rasio yang menunjukkan kemampuan perusahaan meningkatkan laba bersih dibanding tahun sebelumnya. Semakin tinggi rasio pertumbuhan laba, semakin baik kinerja keuangan suatu perusahaan. Penelitian ini bertujuan untuk menguji pengaruh dari current ratio, debt to asset ratio, total asset turnover, dan net profit margin terhadap pertumbuhan laba perusahaan manufaktur sektor barang konsumsi di Bursa Efek Indonesia Tahun 2011-2015. Teknik sampel yang digunakan dalam penelitian ini adalah purposive sampling. Ada 21 perusahaan yang digunakan selama penelitian. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi data panel dengan menggunakan EViews 10. Sampel data diuji dengan menggunakan uji hipotesis dilakukan dengan menggunakan R², uji F, dan uji T. Hasil penelitian ini menunjukkan bahwa secara parsial current ratio (CR), dan debt to asset ratio (DER) berpengaruh signifikan dan negatif, Total Asset Turnover (TAT) berpengaruh signifikan positif sedangkan Net Profit Margin (NPM) tidak berpengaruh signifikan dan positif terhadap pertumbuhan laba manufaktur sektor barang industri di Bursa Efek Indonesia Tahun 2011-2015.
JEL Classification: M41, O43
Pengaruh Likuiditas, Profitabilitas dan Leverage terhadap Prediksi Financial Distress
Authors: Erayanti Rina 
Published: March 2021

ABSTRACT
The importance of financial management as a vital aspect of the company should be considered and managed properly if the company remains to maintain the sustainable business. Development of an early warning system model is needed to anticipate the financial distress, because this model can identify and improve the condition prior to the crisis. This research aims to examine the liquidity (CR, QR), profitability (ROI, ROE), leverage (DER, DAR), the effect of financial distress. The sample used in this research is the company's transportation, infrastructure and utilities sector in Indonesia Stock Exchange (BEI) for the period year 2012-2016. This research uses purposive sampling, which obtained 171 samples of observations from 39 companies. The hypothesis is examined by using regression logistic. The result shows that the ratio of ROI havesignificant effect on the company’s financial distress. While the CR, QR, ROE DER and DAR have no effect on the company’s financial distress.
ABSTRAK
Pentingnya pengelolaan keuangan sebagai aspek vital perusahaan benar-benar harus diperhatikan dan dikelola dengan baik jika perusahaan tetap untuk dapat menjaga kelangsungan hidup usahanya. Diperlukan pengembangan model sistem peringatan untuk mengantisipasi adanya financial distress, karena model ini dapat digunakan sebagai sarana untuk mengidentifikasikan bahkan untuk memperbaiki kondisi sebelum sampai pada kondisi krisis. Studi ini bertujuan untuk meneliti pengaruh likuiditas (CR, QR), profitabilitas (ROI, ROE), leverage (DER, DAR), terhadap prediksi financial distress pada perusahaan sektor transportasi, infrastruktur dan utilities yang terdaftar di Bursa Efek Indonesia periode tahun 2012-2016. Pengambilan sampel dengan menggunakan purposive sampling dan diperoleh sebanyak 171 sampel observasi dari 39 perusahaan. Pengujian hipotesis dilakukan dengan menggunakan regression logistik. Hasil pengujian hipotesis mununjukkan bahwa variabel ROI berpengaruh signifikan terhadap financial distress perusahaan. Sedangkan variabel CR, QR, ROE, DER dan DAR tidak berpengaruh terhadap financial distress perusahaan.
JEL Classification: M40, G18