bluuebunny/crossref_metadata_2025_split huggingface dataset:
iProMix: A decomposition model for studying the function of ACE2 based on bulk proteogenomic data for coronavirus pathogenesis
Authors: Song Xiaoyu , Ji Jiayi , Wang Pei 
Published: May 2021

AbstractBoth SARS-CoV and SARS-CoV-2 use ACE2 receptors to enter epithelial cells in lung and many other tissues to cause human diseases. Genes and pathways that regulate ACE2 may facilitate/inhibit viral entry and replication, and genes and pathways that are controlled by ACE2 may be perturbed during infection, both affecting disease severity and outcomes. It is critical to understand how genes and pathways are associated with ACE2 in epithelial cells by leveraging proteomic data, but an accurate large-scale proteomic profiling at cellular resolution is not feasible at current stage. Therefore, we propose iProMix, a novel framework that decomposes bulk tissue proteomic data to identify epithelial cell component specific associations between ACE2 and other proteins. Unlike existing decomposition based association analyses, iProMix allows both predictors and outcomes to be impacted by cell type composition of the tissue and accounts for the impacts of decomposition variations and errors on hypothesis tests. It also builds in the functions to improve cell type estimation if estimates from existing literature are unsatisfactory. Simulations demonstrated that iProMix has well-controlled false discovery rate and large power in non-asymptotic settings with both correctly and mis-specified cell-type composition. We applied iProMix to the 110 adjacent normal tissue samples of patients with lung adenocarcinoma from Clinical Proteomic Tumor Analysis Consortium, and identified that interferon α and γ pathways were most significantly associated with ACE2 protein abundances in epithelial cells. Interestingly, the associations were sex-specific that the positive associations were only observed in men, while in women the associations were negative.
A hybrid PDE–ABM model for viral dynamics with application to SARS–CoV–2 and influenza
Authors: Marzban Sadegh , Han Renji , Juhász Nóra , Röst Gergely 
Published: May 2021

AbstractWe propose a hybrid partial differential equation – agent-based (PDE–ABM) model to describe the spatio-temporal viral dynamics in a cell population. The virus concentration is considered as a continuous variable and virus movement is modelled by diffusion, while changes in the states of cells (i.e. healthy, infected, dead) are represented by a stochastic agent-based model. The two subsystems are intertwined: the probability of an agent getting infected in the ABM depends on the local viral concentration, and the source term of viral production in the PDE is determined by the cells that are infected.We develop a computational tool that allows us to study the hybrid system and the generated spatial patterns in detail. We systematically compare the outputs with a classical ODE system of viral dynamics, and find that the ODE model is a good approximation only if the diffusion coefficient is large.We demonstrate that the model is able to predict SARS–CoV–2 infection dynamics, and replicate the output ofin vitroexperiments. Applying the model to influenza as well, we can gain insight into why the outcomes of these two infections are different.
Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques
Authors: Munster Vincent J. , Flagg Meaghan , Singh Manmeet , Williamson Brandi N. , Feldmann Friederike , Pérez-Pérez Lizzette , Brumbaugh Beniah , Holbrook Myndi G. , Adney Danielle R. , Okumura Atsushi , Hanley Patrick W. , Smith Brian J. , Lovaglio Jamie , Anzick Sarah L. , Martens Craig , van Doremalen Neeltje , Saturday Greg , de Wit Emmie 
Published: May 2021

AbstractThe emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogenicity, and decreased efficacy of medical countermeasures. Animal models can be used to assess phenotypical changes in the absence of confounding factors that affect observed pathogenicity and transmissibility data in the human population. Here, we studied the pathogenicity of variants of concern (VOC) B.1.1.7 and B.1.351 in rhesus macaques and compared it to a recent clade B.1 SARS-CoV-2 isolate containing the D614G substitution in the spike protein. The B.1.1.7 VOC behaved similarly to the D614G with respect to clinical disease, virus shedding and virus replication in the respiratory tract. Inoculation with the B.1.351 isolate resulted in lower clinical scores in rhesus macaques that correlated with lower virus titers in the lungs, less severe histologic lung lesions and less viral antigen detected in the lungs. We observed differences in the local innate immune response to infection. In bronchoalveolar lavages, cytokines and chemokines were upregulated on day 4 in animals inoculated with D614G and B.1.1.7 but not in those inoculated with B.1.351. In nasal samples, we did not detect upregulation of cytokines and chemokines in D614G or B.1.351-inoculated animals. However, cytokines and chemokines were upregulated in the noses of B.1.1.7-inoculated animals. Taken together, our comparative pathogenicity study suggests that ongoing circulation under diverse evolutionary pressure favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
Electrochemical behaviour of some commercial stainless steel alloys in simulated body fluid electrolytes
Authors: Bahrawy A. , El-Rabiei Mohamed , Elfiky Hesham , Elsayed Nady , Arafa Mohammed , Negem Mosaad 
Published: May 2021

Purpose
The commercial stainless steels have been used extensively in the biomedicine application and their electrochemical behaviour in the simulated body fluid (SBF) are not uncovered obviously. In this research, the corrosion resistance of the commercial stainless steel of Fe–17Cr–xNi alloys (x = 4, 8, 10 and 14) has been studied. This study aims to evaluate the rate of corrosion and corrosion resistance of some Fe–Cr–Ni alloys in SBF at 37°C.

Design/methodology/approach
In this research, the corrosion resistance of the commercial stainless steel of Fe–17Cr–xNi alloys has been studied using open circuit potential, electrochemical impedance spectroscopy and potentiodynamic polarization in the SBF at 37°C and pH 7.4 for a week. Also, the surface morphology of the four alloys was investigated using scanning electron microscopy, elemental composition was obtained via energy dispersive spectroscopy and the crystal lattice structure of Fe–17Cr–xNi alloys was obtained using X-ray diffraction technique. The chemical structure of the protective oxide film has been examined by X-ray photoelectron spectroscopy (XPS) and metals ions released into the solution have been detected after different immersion time using atomic absorption spectroscopy.

Findings
The results revealed that the increase of the Ni content leads to the formation of the stable protective film on the alloys such as the Fe–17Cr–10Ni and Fe–17Cr–14Ni alloys which possess solid solution properties. The Fe–17Cr–14Ni alloy displayed highest resistance of corrosion, notable resistance for localized corrosion and the low corrosion rate in SBF because of the formation of a homogenously protective oxide film on the surface. The XPS analysis showed that the elemental Fe, Cr and Ni react with the electrolyte medium and the passive film is mainly composed of Cr2O3 with some amounts of Fe(II) hydroxide at pH 7.4.

Originality/value
This work includes important investigation to use commercial stainless steel alloys for biomedical application.
The impact of hedonic dining experiences on word of mouth, switching intentions and willingness to pay
Authors: Sukhu Anupama , Bilgihan Anil 
Published: May 2021

PurposeWhen customers decide to dine out, they choose a restaurant for both physiological and psychological reasons. The psychological reasons include the hedonic/enjoyment goal of the consumer. The purpose of this paper is to investigate whether dining experiences that provide a positive or negative hedonic value will influence positive word of mouth (PWOM), switching intentions (SI) and willingness to pay (WTP).Design/methodology/approachTwo survey-based experiments using student (N = 112) and general restaurant consumer samples (N = 270) were conducted to test the proposed theoretical model. The student sample provided internal validity, whereas the general consumer sample provided external validity for the study. Two types of manipulations were used to manipulate positive and negative restaurant service encounters. The second study randomly assigned participants into positive or negative scenarios.FindingsThe results suggest that positive (negative) service encounters lead to higher (lower) hedonic value. Higher hedonic value leads to PWOM, WTP and reduced SI. The findings of this study would assist restaurant managers and service scholars by bridging the gap between experiential and relationship marketing.Originality/valueThe current research investigates the dining out experience with a holistic lens.
Determination of the time-dependent convection coefficient in two-dimensional free boundary problems
Authors: Huntul Mousa , Lesnic Daniel 
Published: May 2021

PurposeThe purpose of the study is to solve numerically the inverse problem of determining the time-dependent convection coefficient and the free boundary, along with the temperature in the two-dimensional convection-diffusion equation with initial and boundary conditions supplemented by non-local integral observations. From the literature, there is already known that this inverse problem has a unique solution. However, the problem is still ill-posed by being unstable to noise in the input data.Design/methodologyFor the numerical discretization, this paper applies the alternating direction explicit finite-difference method along with the Tikhonov regularization to find a stable and accurate numerical solution. The resulting nonlinear minimization problem is solved computationally using the MATLAB routine lsqnonlin. Both exact and numerically simulated noisy input data are inverted.FindingsThe numerical results demonstrate that accurate and stable solutions are obtained.Originality/valueThe inverse problem presented in this paper was already showed to be locally uniquely solvable, but no numerical solution has been realized so far; hence, the main originality of this work is to attempt this task.
Dhanashree Agro: transforming a “Farmer First” model
Authors: Pingali Srinivas Rao , Korem Jyothi Rani 
Published: May 2021

Learning outcomes
The learning outcomes are as follows: to understand the management styles and motivations of SME founders; to understand how SMEs innovate with limited resources; to develop and evaluate technology and platform options to solve operational and business model issues; to build a transforming strategy by leveraging technology; and to understand the agricultural industry and its significance to emerging economies.

Case overview/synopsis
The case is about a Small and Medium Enterprise in India that focussed on the agricultural sector. The company was owner operated and highly successful. As a result, the owner decided to maintain status quo till the COVID-19 crisis forced the company to relook at its strategy and innovate for the second time in its history.

Complexity academic level
MBA.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
Imaging Goa’s B2B sales dilemma: provoke or justify
Authors: Kar Pravat Surya , Dasgupta Meeta 
Published: May 2021

Learning outcomes
Appreciate changing contours of business to business (B2B) purchase and how sellers should adapt their selling style and promotions.

Case overview/synopsis
In the past two decades, imaging Goa (IG) and Azim Shaikh had weathered many business crises. However, as the COVID 19 pandemic unfolded, he became aware of critical fault lines in his B2B selling model. IG offered customised digital display solutions, but its primary source of revenue was B2B selling of interactive flat panel display (IFPD) devices. It, respectively, controlled about 35% and 3% of the market share of IFPD sales, respectively, in Goa and western India. IG’s success in the B2B segment was because of Shaikh’s ability to build strong relationships and customised solutions in an emerging market context. To deal with the COVID pandemic, the Indian Government had imposed a country-wide lockdown, which forced organisations to adopt work from home. This, in turn, created a pull for IFPDs. Yet, very soon Shaikh realised, in the new normal, there was a growing mismatch between his selling efforts and outcomes. Though overall revenue had not fallen much, but the veteran seller had started doubting his tried and tested relational solution selling model. Case dilemma involves the selection of appropriate selling approaches e.g. solution, insight or tiebreaker selling for different situations. This case also offers an opportunity to discuss, how to use online channels to complement B2B selling.

Complexity Academic Level
This teaching case study is suitable for the graduate-level programme in marketing management.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 8: Marketing
Intern to employee conversion via person–organization fit
Authors: Rose Philip S. , Teo Stephen T.T. , Nguyen Diep , Nguyen Nguyen Phong 
Published: May 2021

PurposeInternships are utilized globally to recruit graduate employees. However, there is a limited understanding of the process by which interns convert into regular employees, particularly in non-Western research contexts. Integrating attraction–selection–attrition (ASA) theory and proactive career behaviors, this study identifies the mechanisms influencing interns' intentions to convert into regular employment in host organizations in Vietnam.Design/methodology/approachTime lagged, questionnaire data were collected from 669 final-year undergraduate business and economics students who participated in internship programs in a large metropolitan city in Vietnam.FindingsThe results indicate that the interns who exhibit proactive career behaviors are more likely to foster high-quality reciprocal relationships with their supervisors and work colleagues during internships. These positive relations magnify interns' intentions to become regular employees via their perceived person–organization fit.Practical implicationsThis study has implications for higher education institutions and host organizations when designing internship programs to maximize employment outcomes via conversion of interns into regular employees.Originality/valuePrevious studies have not tested the critical aspect of ASA theory regarding the personalities of the interns when building work-related relationships that result in the person–organization fit before accepting job offers from host organizations.
Design and construction of a sensor analytic system for the monitoring of the parameters of a plastic injection mould
Authors: Babalola Akinloluwa Samuel 
Published: May 2021

PurposeValues of parameters such as temperature, humidity, number of plastic products and the location of plastic injection moulds are required to determine the efficiency of plastic injection moulds with a view to improving the quality of the outputs. This article determined the appropriate sensors for the measurement of these essential parameters in the most suitable form of representation of the data to aid a proficient analysis of the data.Design/methodology/approachThe outputs of these sensors were obtained by connecting the sensors to the general-purpose input/output (GPIO) pins of a Raspberry Pi and writing a Python programme for the connected GPIO pins. The values of the outputs of these sensors were represented in a graphical form. The connection of the Raspberry Pi and the sensors were done with a full-sized breadboard and jumper wires. A computer-aided design (CAD) of the connections was produced using Fritzing software.FindingsThe appropriate sensors determined are MLX90614 infrared thermometer sensor, DHT11 humidity sensor, pixy2 vision sensor and Neo-6m GPS sensor. This study proposed that the sensors analytic system be applied on an industrial plastic injection mould to measure and display the various parameters of the injection moulds for the purpose of understanding and improving the performance of the injection mouldOriginality/valueAn electronic system that provides the continuous values of essential parameters of a plastic injection mould in operation.
Impact of perceived brand authenticity on consumer behavior: an evidence from generation Y in Asian perspective
Authors: Safeer Asif Ali , He Yuanqiong , Lin Yuanyuan , Abrar Muhammad , Nawaz Zubair 
Published: May 2021

PurposeIn the modern era, brand authenticity is one of the most powerful positioning strategies for sustainable business growth. This study investigated the impacts of perceived brand authenticity dimensions (i.e., quality commitment, heritage, sincerity) on brand love to predict Generation Y's behavior from the Asian context.Design/methodology/approachThis is new empirical research that tested the proposed hypotheses through PLS-SEM, as PLS is the most robust technique for predicting consumer behavior. Importantly, consumers (of Generation Y) from five Asian countries contributed to this study, and data collected from 427 Asian millennials on global brands.FindingsThe results analysis revealed that perceived brand authenticity dimensions significantly impacted brand love, which positively affected Asian millennials' behavioral outcomes (i.e., continuous purchase intention and price premium).Research limitations/implicationsThis study investigated dimensions of perceived brand authenticity to predict Asian millennials' behavioral outcomes in a broader perspective. Future researchers may investigate a specific culture with a larger sample size to predict millennials behavior.Practical implicationsThis study has several implications that guide the global managers of several service and manufacturing industries to develop various positioning and relationship strategies for global brands to target Asian markets effectively.Originality/valueUsing attribution theory, this is the first novel research study that empirically discussed the dimensions of perceived brand authenticity, brand love, and Asian millennials' behavior toward global brands.
Shaping bricolage behaviour: the role of personality traits among female entrepreneurs in an emerging economy
Authors: Rahman Syed Abidur , Alam Mirza Mohammad Didarul , Khan Golam Mostafa , Kennedy Rowan Elodie 
Published: May 2021

PurposeThis paper examines the predictive role of personality traits on the entrepreneurial bricolage behaviour of female entrepreneurs in a resource-constrained setting.Design/methodology/approachData were collected using a structured survey questionnaire from female entrepreneurs owning and operating micro-small firms. The analysis and hypotheses testing were performed adopting SEM-PLS3.0 software.FindingsThe results showed that all dimensions of the Big Five personality traits significantly influence entrepreneurial bricolage. In addition, agreeableness, conscientiousness, and intellect were found to be the most important traits in female entrepreneurs for bricolage behaviour.Practical implicationsThe results can help provide a better understanding of the linkages between entrepreneurial traits and bricolage. Development agencies may take up this result to ensure the appropriate social inclusion by supporting female entrepreneurs.Originality/valueTo the authors' best knowledge, this paper is the first empirical study that has investigated the relationship between personality traits and entrepreneurial bricolage.
Understanding the influence of servitization on global value chains: a conceptual framework
Authors: Gölgeci Ismail , Gligor David Marius , Lacka Ewelina , Raja Jawwad Z. 
Published: May 2021

PurposeThis paper examines the servitization phenomenon in the context of global value chains (GVCs) and presents a conceptual framework by connecting the two literature streams—servitization and GVCs—to depict the interconnected multilevel processes by which the influence of servitization on GVC structure and governance is manifested.Design/methodology/approachDrawing on cross-disciplinary literature, the authors develop a multilevel conceptual framework. The theoretically informed framework advances research on servitization and GVCs and provides a line of inquiry to be explored as avenues for future research opportunities.FindingsThe authors argue that servitization instigates the formation of new ecosystems and collaborative structures within GVCs, reduces the fragmentation of the overall network structure and increases embeddedness within the subclusters of GVCs. These changes are expected to be reflected in the increase in the complexity of firms' GVC governance tasks, a greater reliance on relational governance, and an increase in the dependency on local partners in terms of the governance of GVCs.Originality/valueThis conceptual paper establishes the link between servitization and GVCs, anchors the servitization phenomenon in GVCs, explains how servitizing firms can engage in and shape GVCs and offers insights into the servitization-driven changes in GVCs. The conceptual framework is intended to lay the foundation for future empirical research on the link between servitization and GVCs.
Boundary negotiations: a paradox theoretical approach for efficient and flexible modular systems
Authors: Davies Philip , Parry Glenn , Phillips Laura Anne , Ng Irene C.L. 
Published: May 2021

PurposeThe purpose of this paper is to explore the interplay between firm boundary decisions and the management of both efficiency and flexibility and the implications this has for modular design in the provision of advanced services.Design/methodology/approachA single case study in the defence industry employs semi-structured interviews supplemented by secondary data. Data are analysed using thematic analysis.FindingsThe findings provide a process model of boundary negotiations for the design of efficient and flexible modular systems consisting of three phases; boundary ambiguity, boundary defences and boundary alignment.Practical implicationsThe study provides a process framework for boundary negotiations to help organisations navigate the management of both-and efficiency and flexibility in the provision of advanced services.Originality/valueDrawing upon modularity, paradox and systems theory, this article provides novel theoretical insight into the relationship between firm boundary decisions and the management of both-and efficiency vs. flexibility in the provision of product upgrade services.