bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of scalp hair selenium concentrations in Algerian psoriatic individuals usingk0-standardization based on neutron activation analysis method
Authors: Mansouri Ammar , Hamidatou Alghem Lylia , Mokhtari Oum El-Kheir , Benamar Mohammed El-Amine 
Published: May 2021

AbstractPsoriasis is a dermatological disease that affects 2–3% of the Algerian population. Selenium has a positive impact on psoriasis. Selenium plays an important role in protecting free radical damage as a component of the glutathione peroxidase enzyme. The objective of this investigation was to assess the status of selenium in the hair of Algerian patients suffering from psoriasis. Fifty-eight scalp hair samples were collected from Algerian patients with psoriasis, classified by gender and four age groups: 36 females and 22 males, aged between 9 and 79 years. Thirty healthy subjects aged 9–74 years were also surveyed for control purposes. Selenium content was measured for all scalp hair samples using thek0-standardization of neutron activation analysis. The average selenium concentration for controls and patients were 0.39 ± 0.18 and 0.28 ± 0.13 μg/g respectively. Selenium concentration for female and male controls and patients, were 0.35 ± 0.17, 0.47 ± 0.19, 0.28 ± 0.14, and 0.28 ± 0.11 μg/g, respectively. There is a significant difference (p < 0.05) between selenium level in patients and in controls. Selenium concentrations in psoriatics’ scalp hair can be affected by both gender and age. Measured selenium contents have been approved by the quality assurance and quality control procedure (QA/QC).
Predictive Factors of Chemotherapy Initiation after Biliary Drainage for Advanced Biliary Tract Cancer: A Retrospective Multicenter Study
Authors: Azarfane Miloud , Lievre Astrid , Senellart Helene , Desomme Beatrice , Guillouche Pauline , Meyer Jeremy , Bennounna Jaafar , Wallenhorst Timothee , Salimon Maeva , Gournay Jerome , Matysiak-Budnik Tamara , Lim Annie , Edeline Julien , Touchefeu Yann 
Published: May 2021

Background and Aims: In unresectable biliary tract cancers, the management of biliary obstruction is often the first step before introduction of chemotherapy. Our aim was to study the predictive factors of chemotherapy initiation after biliary drainage in a series of patients presenting with advanced biliary tract cancer and obstructive jaundice.
Methods: Data of all patients treated for unresectable biliary tract cancer with initial biliary obstruction requiring a drainage in six institutions, from January 2009 to January 2019, were retrospectively collected.
Results: Among 82 patients included in this study (median age 68 years, men 61%), 48 (59%) received chemotherapy. Median overall survival was 4.9 months (0.2-38.7) in the group of patients who did not receive chemotherapy and 12.2 months (1.9-61.0) in chemotherapy group (HR=2.93; 95%CI: 1.6-5.3; p<0.0001). In univariate analysis, younger age, male gender, Eastern Cooperative Oncology Group (ECOG) score ≤2, high albumin level, low C-reactive protein level, and endoscopic drainage were significantly associated with introduction of chemotherapy. In multivariate analysis, only ECOG score ≤2 at diagnosis (HR=70.4; 95%CI: 4.6-1097.6; p=0.002) and male gender (HR=5; 95%CI: 1.5-16.5; p=0.009), were significant independent predictive factors of chemotherapy introduction. Age and bilirubin level at diagnosis were not significant factors in multivariate analysis.
Conclusions: ECOG score ≤ 2 and male gender were the only independent predictive factors of chemotherapy introduction in unresectable biliary tract cancers. Age or initial bilirubin level were not predictors for chemotherapy introduction. These results might help defining the initial therapeutic strategy.
Alteraciones musculoesqueléticas y adaptaciones biomecánicas durante los trimestres de embarazo: una revisión sistemática
Authors: Quesada Salazar Natalia 
Published: May 2021

El embarazo es un proceso progresivo que involucra cambios de tipo hormonal, mecánico, fisiológico y emocional en la mujer, y que causa que el sistema musculoesquelético se adapte constantemente. Estos cambios, suelen identificarse a través de la postura y la biomecánica de los movimientos en la vida diaria. En esta investigación se realizó una revisión sistemática para encontrar las principales alteraciones y adaptaciones durante el embarazo, incluyendo artículos del 2008 al 2018, con mujeres gestantes sanas, con un solo feto, sin alteraciones musculoesqueléticas previas, de Índice de Masa Corporal (IMC) normal y cualquier metodología de investigación excepto estudios de caso. Se identificaron 13 estudios que refieren evaluar las tres etapas de gestación, edades desde los 20 a los 35 años, así como con diversos objetivos de investigación. La postura de la mujer gestante presenta un aumento de la lordosis lumbar, la curvatura torácica y el ángulo de inclinación anterior de la pelvis. La tarea de sentarse y levantarse de una silla requiere de mayor control del movimiento así como de tiempo de ejecución. La oscilación y las fuerzas de reacción del suelo del Centro de Presión corporal aumentan al estar de pie, lo que resulta en una mayor distancia entre los pies como estrategia de control del equilibrio. Finalmente, la biomecánica de la marcha se adapta a una menor velocidad, longitud de paso y etapa de despegue de los pies del piso, con un aumento del ancho de paso y una mayor base de apoyo. En la gestación, la mujer desarrolla adaptaciones de tipo anatómicas y mecánicas como respuesta a los cambios progresivos experimentados.
Peran Manajemen Krisis Sebagai upaya mempertahankan citra
Authors: Triastuti Ririn Riyani , Ma'arif Abdul Aziz , Ruhiyat Ruhiyat 
Published: May 2021

ABSTRAK
Manajemen krisis sangat dibutuhkan oleh perusahaan yang sedang mengalami krisis khususnya di PT Dirgantara Indonesia (Persero). Manajemen krisis ini jika perusahaan mengalami krisis maka pihak manajemen harus mengembalikan kondisi perusahaan dengan menggunakan proses manajemen krisis ini. Tujuan dari penelitian ini adalah untuk mengetahui beberapa proses manajemen krisis yang telah dilakukan oleh Humas yaitu proses mengidentifikasi, mengisolasi dan mengendalikan krisis di PT Dirgantara Indonesia (Persero). Proses ini merupakan rangkaian dari strategi 3P yaitu strategi pencegahan, strategi persiapan dan strategi penanggulangan. Peneliti menggunakan konsep dari tahap strategi penanggulangan krisis dalam kondisi akut yaitu proses mengidentifikasi, mengisolasi, dan mengendalikan krisis. Penelitian ini menggunakan paradigma konstruktivisme dan metode kualitatif. Peneliti juga menggunakan pendekatan studi kasus yaitu mengenai suatu lembaga atau organisasi dengan berupa fenomena yang ada dan terjadi nyata di suatu lembaga atau organisasi. Hasil dari penelitian ini menerangkan bahwa proses mengidentifikasi yaitu mencari akar permasalahan, proses mengisolasi ini bagaimana cara memberi pemahaman kepada internal dan eksternal, dan proses mengendalikan untuk memulihkan perusahaan yang mengalami krisi dan agar tidak terulang kembali krisis kepada perusahaan
Crisis management is needed by companies that are experiencing a crisis, especially in Indonesian Aerospace (IAe).The management of this crisis if the company's crisis management it must restore the company to use the crisis management process. The purpose of this research is to know some crisis management process that has been done by Public Relations is the process of identifying, isolating and controlling the crisis in Indonesian Aerospace (IAe). This process is a series of strategies 3P such as prevention strategies, preparation strategies and coping strategies. Researchers use the concept of crisis coping strategies in acute conditions that is the process of identifying, isolating, and controlling the crises. This research uses constructivism paradigm and qualitative method. Researchers also use a case study approach that is about an institution or organization with a phenomenon that exists and occurs manifestly in an institution or organization. The results of this research explain that the process of identifying is to find the root of the problems, the process of isolating this how to give understanding to the internal and external, and the process of controlling to restore the company that suffered the crisis and so as not to repeat the crisis.
Implementasi Corporate Social Responsibility Melalui Program Bantuan Solar Tree Light
Authors: Novia Ghina Dwi , Wibawa Darajat , Dulwahab Encep 
Published: May 2021

Tujuan penelitian ini adalah untuk mengetahui bagaimana Bagian Komunikasi Korporasi PT. Len Industri (Persero) dalam mengimplementasikan kegiatan Corporate Social Responsibility (CSR) melalui Program Bantuan Solar Tree Light mulai dari tahap perencanaan, pelaksanaan, hingga tahap evaluasi. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data melalui wawancara, observasi dan studi dokumentasi. Konsep yang digunakan adalah konsep implementasi dan konsep Corporate Social Responsibility (CSR) dengan memperhatikan aspek “3P” atau Triple Bottom Line : Profit-Planet-People dari Jon Elkingston. Hasil penelitian menunjukkan bahwa Implementasi Corporate Social Responsibility (CSR) melalui Program Bantuan Solar Tree Light dimulai dengan perencanaan yakni melaksanakan rapat internal, menetapkan tujuan Corporate Social Responsibility (CSR), menjalankan operasionalisasi proposal/surat, melakukan sosialisasi, dan melakukan survey. tempat. Pelaksanaan dengan cara melakukan pemasangan Solar Tree Light, melakukan serah terima Solar Tree Light, dan melakukan kegiatan sharing knowledge dan terakhir evaluasi dengan tahapan berupa kegiatan monitoring dan evaluasi internal.
The purpose of this research is to find out how the Corporate Communication Section of PT. Len Industri (Persero) in implementing Corporate Social Responsibility (CSR) activities through the Surya Tree Light Assistance Program starting from the planning, implementation, and evaluation stages. The method used in this study is descriptive qualitative with data collection techniques through interviews, and documentation studies. The concept used is the implementation concept and concept of Corporate Social Responsibility (CSR) by taking into account the "3P" or Triple Bottom Line aspects: Profit-Planet-People from Jon Elkingston. The results showed that the Implementation of Corporate Social Responsibility (CSR) through the Solar Tree Light Assistance Program began with internal internal planning, setting goals for Corporate Social Responsibility (CSR), carrying out the operation of proposals/ letters, conducting socialization, and conducting site surveys. Implementation by installing Solar Tree Light, making handover of Solar Tree Light, and conducting knowledge sharing activities and lastly evaluating with internal monitoring and evaluation activities.
Manajemen Humas dalam Mempertahankan Sponsor
Authors: Sidik Iik Jafar , Setiana Wiryo , Astuti Dyah Rahmi 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui proses yang dilakukan PT. Persib Bandung Bermartabat dalam menjalankan program atau kegiatan Manajemen Humas dalam Mempertahankan Sponsor mulai dari proses defining Public Relations, planning and programming, taking action and communication hingga evaluating the program. Metode penelitian yang digunakan yaitu menggunakan studi kasus dengan pendekatan kualitiatif. Hasil penelitian menunjukan bahwa Manajemen Humas dalam Mempertahankan Sponsor dimulai dengan proses defining Public Relations problem, planning and programming, taking action and communication dan diakhiri dengan evaluating the program,sehingga melalui proses ini dapat ditentukan masalah apa yang akan dijadikan suatu fokus kegiatan melalui analisa data-data yang didapatkan, mampu menjadikan sebuah program atau kegiatan dapat terlaksana dengan efektif, melakukan kinerja serta berkomunikasi didalam sebuah program atau kegiatan dengan tujuan untuk menentukan waktu, kapan, dimana, dan bagaimana program atau kegiatan tersebut dilaksanakan, dan mengevaluasi dari keseluruhan program atau kegiatan yang telah dilaksanakan untuk mengukur sejauh mana pencapaian yang sudah dilakukan.
This study aims to determine the process carried out by PT. Persib Bandung Bermartabat in carrying out Public Relations Management programs or activities in Maintaining Sponsors starting from the defining process of Public Relations, planning and programming, taking action and communication to evaluating the program. The research method is using a case study with a qualitative approach. The results showed that Public Relations Management in Maintaining Sponsors began with the defining process of Public Relations problems, planning and programming, taking action and communication and evaluating the program, so that through this process what problems would be a focus of activities through analysis – the obtained, is able to make a program or activity can be carried out effectively, perform performance and communicate in a program with the aim of determining, and evaluating the entire program has been carried out to measure the extent of the achievements that have been made.
Pengelolaan Corporate Social Responsibility Beasiswa Bank Indonesia
Authors: Afifah Fauziyah Nur , Rosyidi Imron , Dulwahab Encep 
Published: May 2021

ABSTRAK
Tujuan penelitian ini menghasilkan data kualitatif dalam studi kasus Pengelolaan Corporate Sosial Responsibility Bank Indonesia melalui Pemberian Beasiswa. Tujuannya untuk mengetahui proses Mendefinisikan Masalah, proses perumusan Perencanaan, Mengambil Tindakan, dan Mengevaluasi dari program beasiswa Bank Indonesia. Penelitian ini menggunakan konsep Four Steps PR Process. Metode yang digunakan yaitu metode studi kasus dengan pendekatan kualitatif. Teknik pengumpulan data skripsi ini observasi, wawancara mendalam dan dokumentasi. Hasil penelitian: 1) Mendefinisikan masalah yaitu menentukan siapa saja yang berhak mendapatkan beasiswa. 2) Merencanakan sasaran dan informasi, pengelolaan GenBI. 3) Menenentukan penerima menerima beasiswa, menentukan peran GenBI dalam keikutsertaanya dalam setiap kegiatan BI, dan struktur kepengurusan organisasi GenBI. 4) Evaluasi program beasiswa BI.
Kata Kunci : Pengelolaan, Corporate Sosial Responsibility, Beasiswa.
ABSTRACT
The purpose of this study was to produce qualitative data in a case study of the Management of Corporate Social Responsibility at Bank Indonesia through the Granting of Scholarships. The aim is to find out the process of defining the problem, the process of formulating planning, taking action, and evaluating from the Bank Indonesia scholarship program. This study uses the concept of the Four Steps PR Process. The method used is the case study method with a qualitative approach. This thesis data collection technique is observation, in-depth interviews and documentation. Research results: 1)Defining the problem is to determine who is entitled to a scholarship. 2)Planning goals and information, managing GenBI. 3)Determine the recipient to receive a scholarship, determine the role of GenBI in its participation in every BI activity, and the management structure of the GenBI organization. 4)Evaluation of the BI scholarship program.
Keywords : Management, Corporate Social Responsibility, Scholarship
Marketing Public Relations Radio Ardan dalam Mempertahankan Minat Pendengar
Authors: Affiyandi Muhamad Fakhri , Setiana Wiryo , Cholidah Lida Imelda 
Published: May 2021

Tujuan penelitian ini adalah untuk mengetahui bagaimana Radio Ardan dalam melakukan kegiatan Marketing Public Relations berupa Pull Strategy, Push Strategy, Pass Startegy dalam mempertahankan minat pendengar. Metode yang digunakan dalam penelitian ini adalah studi kasus, untuk mengetahui aspek “how” dan “why” pada Marketing Public Relations yang dilakukan Radio Ardan dalam mempertahankan minat pendengar. Teknik pengumpulan data yang digunakan adalah wawancara mendalam dan observasi partisipatori pasif. Hasil penelitian menunjukkan bahwa Marketing Public Relations yang dilakukan oleh Radio Ardan dalam mempertahankan minat pendengar dimulai dengan Pull Strategy dimana pada strategi tahapannya terdiri dari menggunakan media sosial, umbul-umbul, pemilihan cerita, dan penyajian cerita, selanjutnya pada Push Strategy dengan tahapan menjalin kerjasama, nightmare school, mengadakan kuis, dan merilis buku, dan terakhir adalah Pass Strategy, dimana hasil dari pada tahap ini dimulai dengan ritual, ekspedisi life, menjalin kerjasama dengan jurnalisa, dan sponsorship.

The purpose of this study was to find out how Radio Ardan in conducting Public Relations Marketing activities in the form of Pull Strategy, Push Strategy, Startegy Pass in maintaining the interest of listeners. The method used in this study is a case study, to find out the aspects of "how" and "why" in Marketing Public Relations conducted by Radio Ardan in maintaining the interest of listeners. Data collection techniques used were in-depth interviews and passive participatory observation. The results showed that Marketing Public Relations carried out by Radio Ardan in maintaining listeners' interest began with Pull Strategy where the stage strategy consisted of using social media, banners, story selection, and story presentation, then on Push Strategy with the stages of collaborating, nightmare school, holding quizzes, and releasing books, and finally the Pass Strategy, where the results at this stage begin with rituals, life expeditions, collaborating with journalism, and sponsorship.
Keywords : Marketing Public Relations; Listener Interest; Radio
Expression and Role of Parathyroid Hormone-Related Protein in Human Renal Proximal Tubule Cells during Recovery from ATP Depletion
Authors: GARCÍA-OCAN[Combining Tilde]A ADOLFO , GALBRAITH SUSAN C. , VAN WHY SCOTT K. , YANG KAI , GOLOVYAN LINA , DANN PAMELA , ZAGER RICHARD A. , STEWART ANDREW F. , SIEGEL NORMAN J. , ORLOFF JOHN J. 
Published: May 2021

Abstract.
Parathyroid hormone (PTH)-related protein (PTHrP) is widely expressed in normal fetal and adult tissues and regulates growth and differentiation in a number of organ systems. Although various renal cell types produce PTHrP, and PTHrP expression in rat proximal renal tubules is upregulated in response to ischemic injury in vivo, the role of PTHrP in the kidney is unknown. To study the effects of injury on PTHrP expression and its consequences in more detail, the immortalized human proximal tubule cell line HK-2 was used in an in vitro model of ATP depletion to mimic in vivo renal ischemic injury. These cells secrete PTHrP into conditioned medium and express the type I PTH/PTHrP receptor. Treatment of confluent HK-2 cells for 2 h with substrate-free, glucose-free medium containing the mitochondrial inhibitor antimycin A (1 μM) resulted in 75% depletion of cellular ATP. After an additional 2 h in glucose-containing medium, cellular ATP levels recovered to approximately 75% of baseline levels. PTHrP mRNA levels, as measured in RNase protection assays, peaked at 2 h into the recovery period (at four times baseline expression). The increase in PTHrP mRNA expression was correlated with an increase in PTHrP protein content in HK-2 cells at 2 to 6 h into the recovery period. Heat shock protein-70 mRNA expression was not detectable under baseline conditions but likewise peaked at 2 h into the recovery period. Treatment of HK-2 cells during the recovery period after injury with an anti-PTHrP(1-36) antibody (at a dilution of 1:250) resulted in significant reductions in cell number and uptake of [3H]thymidine, compared with nonimmune serum at the same titer. Similar results were observed in uninjured HK-2 cells. It is concluded that this in vitro model of ATP depletion in a human proximal tubule cell line reproduces the pattern of gene expression previously observed in vivo in rat kidney after ischemic injury and that PTHrP plays a mitogenic role in the proliferative response after energy depletion.
IgA Interaction with Carboxy-Terminal 43-kD Fragment of Fibronectin in IgA Nephropathy
Authors: WAGA SHINOBU , SUGIMOTO KAZUHIKO , TANAKA HIROSHI , ITO TATSUO , NAKAHATA TOHRU , TATEYAMA TAKASHI , KAKIZAKI YOSHIKI , YOKOYAMA MASARU 
Published: May 2021

Abstract.
IgA deposition in the glomerular mesangial matrix is a prerequisite for the diagnosis of IgA nephropathy, and circulating IgA-containing complex has been implicated in this process. Since fibronectin is known to be involved in the assembly of extracellular matrix, this study was conducted to investigate whether fibronectin and its fragments are present in sera of patients and are capable of binding IgA1. Sera from patients with IgA nephropathy were purified by heparin-affinity chromatography, and column eluate were analyzed for the presence of fibronectin using Western blot and a set of anti-fibronectin monoclonal antibodies. Native fibronectin was digested with cathepsin D to obtain fragments similar to those of serum fibronectin. The capacity of fibronectin to bind IgA was examined with a mixture of purified IgA1 and cathepsin D-digested fibronectin fragments. A 43-kD carboxy-terminal fragment of fibronectin was detected in samples derived from sera of patients with IgA nephropathy but not in healthy control subjects. A similar-sized fragment was generated by cathepsin D digestion of the native molecule and was shown to bind to IgA1 in vitro. Since the carboxy-terminal domain is known to be critical in assembling exogenous fibronectin into the extracellular matrix, the affinity to IgA1 to a fragment found in patients may have pathogenic potential to mediate extracellular IgA deposition in IgA nephropathy.
The Leukotriene B4 Receptor Antagonist ONO-4057 Inhibits Nephrotoxic Serum Nephritis in WKY Rats
Authors: SUZUKI SATORU , KURODA TAKESHI , KAZAMA JUN-ICHIROU , IMAI NAOFUMI , KIMURA HIDEKI , ARAKAWA MASAAKI , GEJYO FUMITAKE 
Published: May 2021

Abstract.
To evaluate the role of leukotriene B4 (LTB4) in glomerulonephritis, this study was conducted to examine whether ONO-4057, an LTB4 receptor antagonist, moderated nephritis caused by the injection of nephrotoxic serum (NTS) into Wistar-Kyoto rats. Rats were given intraperitoneal injections of ONO-4057 or phosphate-buffered saline 24 h before the injection of NTS. These rats subsequently received equal doses of ONO-4057 or phosphate-buffered saline 3 h and 1, 2, 3, 4, 5, and 6 d later. Compared with the control groups, ONO-4057 treatment significantly reduced proteinuria and hematuria, suppressed the glomerular accumulation of monocytes/macrophages, and reduced the formation of crescentic glomeruli in a dose-dependent manner. These results suggest that LTB4 is responsible for the crescentic formations and renal dysfunction associated with NTS nephritis. The LTB4 receptor antagonist ONO-4057 may thus be beneficial in the treatment of crescentic glomerulonephritis.
Adoptively Transferable Tolerance Induced by CD45RB Monoclonal Antibody
Authors: GAO ZUHUA , ZHONG ROBERT , JIANG JIFU , GARCIA BERTHA , XING JING JING , WHITE MARTIN J. , LAZAROVITS ANDREW I. 
Published: May 2021

Abstract.
The phenomenon of rejection remains the most serious problem in transplantation. The ultimate goal in transplant immunology is to develop therapeutic strategies that lead to tolerance. It has been shown that two injections of a monoclonal antibody to CD45RB leads to indefinite acceptance of renal allografts in mice. Moreover, the CD45RB monoclonal antibody reverses acute rejection and still induces tolerance. The purpose of this study was to assess mechanisms that could underlie this therapeutic benefit. It was shown that splenic lymphocytes from tolerant animals augmented proliferation in allogeneic mixed lymphocyte reactions against donor alloantigens, and the serum of tolerant mice contained donor-specific antibodies, mainly of the IgG1 isotype, suggesting the presence of TH2 cytokines. Tolerance could not be broken by interleukin-2 infusion, but tolerance could be adoptively transferred by transfusion of tolerant mouse CD4+ splenic lymphocytes into naive allografted animals. These data suggest that an active immunoregulatory mechanism is partly responsible for the therapeutic effect. CD45RB-directed therapy may find clinical application in organ transplantation in human patients.