bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and first‐year mortality, by lesion level, among infants with spina bifida in the New York State Birth Defects Registry, 2008–2017
Authors: Sullivan Anaclare M. , Herdt Michele 
Published: December 2021

AbstractBackgroundSpina bifida is the most common neural tube defect. It has been associated with increased mortality, disability, and may require lifelong medical care. Higher‐level lesions have been shown to be associated with increased mortality in infants with spina bifida.MethodsA study was conducted using data from infants with myelomeningocele and related spina bifida reported to the New York State Birth Defects Registry for birth years 2008 through 2017. Descriptive statistics were conducted. Cox regression was used to calculate adjusted hazard ratios for mortality by age one, by lesion level. Hazard ratios were adjusted for birthweight and maternal race/ethnicity.ResultsOverall survival at age one was 90.7%. Cervical‐level lesions had an increased risk of mortality compared to lumbar‐level lesions (HR 8.32; 95% CI: 2.56, 27.05). No statistically significant associations were found for sacral‐level lesions compared to lumbar‐level lesions.ConclusionThese results suggest that infants with cervical‐level spina bifida have a higher risk of death by age one than those with other lesion levels.
Investigating and modeling the effect of light intensity on Rhodopseudomonas palustris growth
Authors: Ross Brandon S. , Pott Robert W. M. 
Published: December 2021

AbstractPhotosynthetic bacteria can be useful biotechnological tools—they produce a variety of valuable products, including high purity hydrogen, and can simultaneously treat recalcitrant wastewaters. However, while photobioreactors have been designed and modeled for photosynthetic algae and cyanobacteria, there has been less work on understanding the effect of light in photosynthetic bacterial fermentations. To design photobioreactors, and processes using these organisms, robust models of light penetration, utilization, and conversion are needed. This stydy uses experimental data from a tubular photobioreactor designed to focus in on light intensity effects, to model the effect of light intensity on the growth of Rhodopseudomonas palustris, a model photosynthetic bacterium. The work demonstrates that growth is controlled by light intensity, and that this organism does experience photolimitation below 200 W/m2 and photoinhibition above 600 W/m2. This has implications for outdoor applications, as there will be low growth during the periods of limited light, and growth may be inhibited during the light intensive hours of mid‐day. Further, the work presents a model for light penetration in cylindrical photobioreactors, which tends to be the most common geometry. The model developed showed good fit to the experimental data for each light intensity investigated, with high R2 values and NRMSE values all below 20%. The work extends the modeling tools for these organisms, and will allow for better photobioreactor design, and the integration of modeling tools in designing processes which use photosynthetic bacteria.
The added value of multi‐state modelling in a randomized controlled trial: The HOVON 102 study re‐analyzed
Authors: Bakunina Katerina , Putter Hein , Versluis Jurjen , Koster Eva A. S. , van der Holt Bronno , Manz Markus G. , Breems Dimitri A. , Gjertsen Bjorn T. , Cloos Jacqueline , Valk Peter J. M. , Passweg Jakob , Pabst Thomas , Ossenkoppele Gert J. , Löwenberg Bob , Cornelissen Jan J. , de Wreede Liesbeth C. 
Published: December 2021

AbstractClofarabine is an active antileukemic drug for subgroups of patients with acute myeloid leukemia (AML). Multi‐state models can provide additional insights to supplement the original intention‐to‐treat analysis of randomized controlled trials (RCT). We re‐analyzed the HOVON102/SAKK30/09 phase III RCT for newly diagnosed AML patients, which randomized between standard induction chemotherapy with or without clofarabine. Using multi‐state models, we evaluated the effects of induction chemotherapy outcomes (complete remission [CR], measurable residual disease [MRD]), and post‐remission therapy with allogeneic stem cell transplantation [alloSCT] on relapse and death. Through the latter a consistent reduction in the hazard of relapse in the clofarabine arm compared to the standard arm was found, which occurred irrespective of MRD status or post‐remission treatment with alloSCT, demonstrating a strong and persistent antileukemic effect of clofarabine. During the time period between achieving CR and possible post‐remission treatment with alloSCT, non‐relapse mortality was higher in patients receiving clofarabine. An overall net benefit of treatment with clofarabine was identified using the composite endpoint current leukemia‐free survival (CLFS). In conclusion, these results enforce and extend the earlier reported beneficial effect of clofarabine in AML and show that multi‐state models further detail the effect of treatment on competing and series of events.
Neurobiology of cancer: Definition, historical overview, and clinical implications
Authors: Mravec Boris 
Published: December 2021

AbstractStudies published in the last two decades have clearly demonstrated that the nervous system plays a significant role in carcinogenesis, the progression of cancer, and the development of metastases. These studies, combining oncological and neuroscientific approaches, created the basis for the emergence of a new field in oncology research, the so‐called “neurobiology of cancer.” The concept of the neurobiology of cancer is based on several facts: (a) psychosocial factors influence the incidence and progression of cancer diseases; (b) the nervous system affects DNA mutations and oncogene‐related signaling; (c) the nervous system modulates tumor‐related immune responses; (d) tumor tissues are innervated; (e) neurotransmitters released from nerves innervating tumor tissues affect tumor growth and metastasis; (f) alterations or modulation of nervous system activity affects the incidence and progression of cancers; (g) tumor tissue affects the nervous system. The aim of this review is to characterize the pillars that create the basis of cancer neurobiology, to describe recent research advances of the nervous system's role in cancer diseases, and to depict potential clinical implications for oncology.
Assessing fatigue in childhood cancer survivors: Psychometric properties of the Checklist Individual Strength and the Short Fatigue Questionnaire––a DCCSS LATER study
Authors: Penson Adriaan , Walraven Iris , Bronkhorst Ewald , Grootenhuis Martha A. , Tissing Wim J. E. , van der Pal Helena J. H. , de Vries Andrica C. H. , van den Heuvel‐Eibrink Marry M. , Neggers Sebastian , Versluys Birgitta A. B. , Louwerens Marloes , Pluijm Saskia M. F. , Blijlevens Nicole , van der Heiden‐van der Loo Margriet , Kremer Leontien C. M. , van Dulmen‐den Broeder Eline , Knoop Hans , Loonen Jacqueline 
Published: December 2021

AbstractBackgroundFatigue is often reported by patients with childhood cancer both during and after cancer treatment. Several instruments to measure fatigue exist, although none are specifically validated for use in childhood cancer survivors (CCS). The aim of the current study was to present norm values and psychometric properties of the Checklist Individual Strength (CIS) and Short Fatigue Questionnaire (SFQ) in a nationwide cohort of CCS.MethodsIn total, 2073 participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort. Normative data, construct validity, structural validity, and internal consistency were calculated for the CIS and SFQ. In addition, reliability and a cutoff score to indicate severe fatigue were determined for the SFQ.ResultsCorrelations between CIS/SFQ and vitality measures asking about fatigue were high (>0.8). Correlations between CIS/SFQ and measures of different constructs (sleep, depressive emotions, and role functioning emotional) were moderate (0.4–0.6). Confirmatory factor analysis resulted in a four‐factor solution for the CIS and a one‐factor solution for the SFQ with Cronbach's alpha for each (sub)scale showing good to excellent values (>0.8). Test–retest reliability of the SFQ was adequate (Pearson's correlation = 0.88; ICC = 0.946; weighted Cohen's kappa item scores ranged 0.31–0.50) and a cut‐off score of 18 showed good sensitivity and specificity scores (92.6% and 91.3%, respectively).ConclusionThe current study shows that the SFQ is a good instrument to screen for severe fatigue in CCS. The CIS can be used as a tool to assess the multiple fatigue dimensions in CCS.
Modified FOLFIRINOX versus sequential chemotherapy (FOLFIRI/FOLFOX) as a second‐line treatment regimen for unresectable pancreatic cancer: A real‐world analysis
Authors: Tezuka Shun , Ueno Makoto , Oishi Ritsuko , Nagashima Shuhei , Sano Yusuke , Kawano Kuniyuki , Tanaka Satoshi , Fukushima Taito , Asama Hiroyuki , Konno Naoki , Kobayashi Satoshi , Morimoto Manabu , Maeda Shin 
Published: December 2021

AbstractBackgroundAlthough second‐line treatment for pancreatic cancer has been proven to have survival benefit, it is not clear which is the most preferred regimen. This study compared the efficacy and safety of modified FOLFIRINOX (mFOLFIRINOX) and sequential chemotherapy (FOLFIRI/FOLFOX) as a second‐line treatment regimen for unresectable pancreatic cancer.MethodThis was a retrospective single‐center analysis of all patients who initiated treatment with mFOLFIRINOX or sequential chemotherapy from December 2014 to May 2019 as a second‐line treatment for unresectable pancreatic cancer. The sequential chemotherapy group included all patients who initiated sequential chemotherapy. For efficacy analysis, the primary endpoint was overall survival (OS) of all patients, excluding those with locally advanced pancreatic cancer. For safety analysis, we assessed the incidence of grade ≥3 adverse events in all patients.ResultsSeventy‐four patients (mFOLFIRINOX group, n = 44; sequential chemotherapy group, n = 30) were included. OS tended to be slightly prolonged in the mFOLFIRINOX group than in the sequential chemotherapy group (median 10.6 [95% confidence interval {CI} 5.9–13.8] vs. 8.5 [95% CI 5.0–12.2] months; hazard ratio 1.40 [95% CI 0.71–2.71]). The objective response rate and disease control rate were 8.1% and 64.9%, respectively, in the mFOLFIRINOX group and 3.8% and 42.3%, respectively, in the sequential chemotherapy group. In safety analysis, the grade ≥3 rates of neutropenia, febrile neutropenia, and anorexia were 40.9%, 6.8%, and 18.2%, respectively, in the mFOLFIRINOX group and 3.3%, 0%, and 3.3%, respectively, in the sequential chemotherapy group.ConclusionsWhereas efficacy tended to be slightly better in the mFOLFIRINOX group than in the sequential chemotherapy group, given the higher incidence of grade ≥3 adverse events with mFOLFIRINOX than with sequential chemotherapy, sequential chemotherapy is a regimen with better risk–benefit balance than mFOLFIRINOX, and can be considered a second‐line treatment option for patients with unresectable pancreatic cancer.
Development and prospective validation of a risk score model in guiding individualized concurrent chemoradiotherapy in stage II nasopharyngeal carcinoma in intensity‐modulated radiotherapy era
Authors: Yang Shan‐Shan , Pang Ya‐Jun , Wang Zhi‐Qiang , Zhang Bao‐Yu , Liu Zhi‐Qiao , Chen En‐Ni , OuYang Pu‐Yun , Xie Fang‐Yun 
Published: December 2021

AbstractPurposeWe aimed to develop and prospectively validate a risk score model to guide individualized concurrent chemoradiotherapy (CCRT) for patients with stage II nasopharyngeal carcinoma (NPC) in intensity‐modulated radiotherapy (IMRT) era.Materials and MethodsIn total, 1220 patients who received CCRT or IMRT alone were enrolled in this study, including a training cohort (n = 719), a validation cohort (n = 307), and a prospective test cohort (n = 194). Patients were stratified into different risk groups by a risk score model based on independent prognostic factors, which were developed in the training cohort. Survival rates were compared by the log‐rank test. The validation and prospective test cohorts were used for validation.ResultsTotal tumor volume, Epstein–Barr virus DNA, and lactate dehydrogenase were independent risk factors for failure‐free survival (FFS, all p < 0.05). A risk score model based on these three risk factors was developed to classify patients into low‐risk group (no risk factor, n = 337) and high‐risk group (one or more factors, n = 382) in the training cohort. In the high‐risk group, CCRT had better survival rates than IMRT alone (5‐year FFS: 82.6% vs. 74.0%, p = 0.028). However, there was no survival difference between CCRT and IMRT alone either in the whole training cohort (p = 0.15) or in the low‐risk group (p = 0.15). The results were verified in the validation and prospective test cohorts.ConclusionA risk score model was developed and prospectively validated to precisely select high‐risk stage II NPC patients who can benefit from CCRT, and thus guided individualized treatment in IMRT era.
A randomized controlled clinical trial of cardiac telerehabilitation with a prolonged mobile care monitoring strategy after an acute coronary syndrome
Authors: Dalli Peydró Ernesto , Sanz Sevilla Nuria , Tuzón Segarra María T. , Miró Palau Vicente , Sánchez Torrijos Jorge , Cosín Sales Juan 
Published: December 2021

AbstractBackgroundCenter‐based cardiac rehabilitation (CBCR) improves health outcomes but has some limitations. We designed and validated a telerehabilitation system to overcome these barriers.MethodsWe included 67 low‐risk acute coronary syndrome patients in a randomized controlled trial allocated 1:1 to a 10‐month cardiac telerehabilitation (CTR) program or an 8‐week CBCR program. Patients underwent ergospirometry, blood tests, anthropometric measurements, IPAQ, PREDIMED, HADS, and EQ‐5D questionnaires at baseline and 10 months. Data collectors were blinded to the treatment groups.ResultsThe intention‐to‐treat analysis included 31 patients in the CTR group and 28 patients in the CBCR group. The primary outcome showed increased physical activity according to the IPAQ survey in the CTR group compared to the CBCR group (median increase 1726 METS‐min/week vs. 636, p = .045). Mean VO2max increased 1.62 ml/(kg min) (95% confidence interval [CI]: 0.56–2.69, p < .004) from baseline in the CTR group, and 0.60 mL/(kg min) (p = .40) in the CBCR group. Mean apoB/apoA‐I ratio decreased 0.13 (95% CI: −0.03 to 0.24, p = .017) in the CTR group, with no significant change in the CBCR group (p = .092). The median non‐HDL cholesterol increased by 7.3 mg/dl (IQR: −2.4 to 18.6, p = .021) in the CBCR group, but the increase was not significant in the CTR group (p = .080). Adherence to a Mediterranean diet, psychological distress, and quality of life showed greater improvement in the CTR group than in the CBCR group. Return‐to‐work time was reduced with the telerehabilitation strategy.ConclusionThis system allows minimal in‐hospital training and prolonged follow‐up. This strategy showed better results than CBCR.
NT Pro‐BNP can be used as a risk predictor of clinical atrial fibrillation with or without left atrial enlargement
Authors: Zhao Xiao , Li Hao , Liu Cai , Ren Yuanyuan , Sun Chaofeng 
Published: December 2021

AbstractBackgroundNT Pro‐BNP is a blood marker secreted by cardiomyocytes. Myocardial stretch is the main factor to stimulate NT Pro‐BNP secretion in cardiomyocytes. NT Pro‐BNP is an important risk factor for cardiac dysfunction, stroke, and pulmonary embolism. So does atrial myocyte stretching occur when patients have atrial fibrillation (AF)? Whether atrial muscle stretch induced by AF leads to increased NT Pro‐BNP remains unclear. The purpose of this study is to investigate the relationship between NT Pro‐BNP and AF.HypothesisAF can cause changes in myocardial tension. Changes in myocardial tension may lead to increased secretion of NT Pro‐BNP. We hypothesize that NT Pro‐BNP may increase in AF with or without LAD enlargement.MethodsThis clinical study is an observational study and has been approved by the Ethics Committee of the First Affiliated Hospital of Xi'an Jiaotong University. Ethical approval documents is attached. The study retrospectively reviewed 1345 patients with and without AF. After excluding 102 patients who were not eligible, the final total sample size was 1243 cases: AF group 679 patients (378, 55.7% males) and non‐AF group 564 patients (287, 50.8% males). NT Pro‐BNP was observed in AF group and non‐AF group with or without LAD. After adjusting for age, gender, BMI, left atrial diameter, hypertension, diabetes, coronary heart disease, and cerebral infarction, NT Pro‐BNP remains statistically significant with AF.ConclusionNT Pro‐BNP can be used as a risk predictor of AF with or without left atrial enlargement.
A Systematic Review and Analysis of the Use of Polygenic Scores in Pharmacogenomics
Authors: Johnson Danielle , Wilke MacKenzie A.P. , Lyle Sarah M. , Kowalec Kaarina , Jorgensen Andrea , Wright Galen E.B. , Drögemöller Britt I. 
Published: December 2021

Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction. The application of these scores to pharmacogenomics provides new opportunities to improve the prediction of treatment outcomes. To gain insight into this area of research, we conducted a systematic review and accompanying analysis. This review uncovered 51 papers examining the use of PGSs for drug‐related outcomes, with the majority of these papers focusing on the treatment of psychiatric disorders (n = 30). Due to difficulties in collecting large cohorts of uniformly treated patients, the majority of pharmacogenomic PGSs were derived from large‐scale genome‐wide association studies of disease phenotypes that were related to the pharmacogenomic phenotypes under investigation (e.g., schizophrenia‐derived PGSs for antipsychotic response prediction). Examination of the research participants included in these studies revealed that the majority of cohort participants were of European descent (78.4%). These biases were also reflected in research affiliations, which were heavily weighted towards institutions located in Europe and North America, with no first or last authors originating from institutions in Africa or South Asia. There was also substantial variability in the methods used to develop PGSs, with between 3 and 6.6 million variants included in the PGSs. Finally, we observed significant inconsistencies in the reporting of PGS analyses and results, particularly in terms of risk model development and application, coupled with a lack of data transparency and availability, with only three pharmacogenomics PGSs deposited on the Polygenic Score Catalog. These findings highlight current gaps and key areas for future pharmacogenomic PGS research.
Soehendra stent retriever as a useful delivery device of drainage stent for passing an impacted cystic duct stone in a patient with acute cholecystitis
Authors: Ban Tesshin , Kubota Yoshimasa , Takahama Takuya , Ando Tomoaki , Joh Takashi 
Published: December 2021

AbstractEndoscopic transpapillary gallbladder drainage is an alternative procedure for patients with acute cholecystitis. However, this procedure is technically challenging because the drainage stent is sometimes obstructed by an impacted cystic duct stone, even if the guidewire is advanced into the gallbladder. In this report, the front end of a standard endoscopic retrograde cholangiopancreatography catheter was cut to an appropriate length as a drainage stent for transpapillary gallbladder drainage. However, this modified stent became stuck because of an impacted cystic duct stone. The Soehendra stent retriever was used as a stent delivery device in this setting. A Soehendra stent retriever with clockwise rotation was coupled with the drainage stent. Integrated devices provide a stent tip for pushability and torqueability. The stuck drainage stent at the impacted cystic duct stone resumed advancement into the gallbladder. After stent indwelling, decoupling was easy under counterclockwise rotation of the Soehendra stent retriever.
Drivers of alien species composition in bird markets across the world
Authors: Su Shan , Vall‐llosera Miquel , Cassey Phillip , Blackburn Tim M. , Carrete Martina , Tella José L. 
Published: December 2021

AbstractThe global pet trade is a major pathway for the introduction of invasive alien species. The composition of species selected for transport is driven by market demands, which may be influenced by a combination of both historical and cultural factors. We compared Eastern (Taiwan) and Western (Australia and the Iberian Peninsula) bird markets to explore factors associated with the species composition and geographic origin of the birds for sale. We used a bespoke randomization test to compare species composition, geographic origins, and species overlap at different taxonomic levels among bird markets across countries. Alien species identified in the study accounted for more than 10% of the world's bird species. Parrots and songbirds were the most common alien bird taxa traded across all markets. In both Iberian and Australian markets, there was a strong bias toward parrots, waxbills, gamebirds, and finches. In Taiwan, species traded more than expected were parrots, waxbills, starlings, and leafbirds. Neotropical species were the most traded group in the three markets. Afrotropical species were also traded more than expected in Iberian and Australian markets, while the Taiwanese traded more alien species from neighboring Asian regions. The bird trade focuses on the same few bird groups worldwide. The composition and origin of species preferred in the Western markets may be influenced by colonial histories, cultural similarity, and strict regulations on wildlife importation, while species preferences in Eastern markets are strongly influenced by regional culture and proximity. Propagule pressure is a dominant factor influencing the success of biological invasions; it is important to recognize differences in the composition of bird markets among regions because they can translate into different invasion risks, among other factors.
Acute and lagged fitness consequences for a sagebrush obligate in a post mega‐wildfire landscape
Authors: Anthony Christopher R. , Foster Lee J. , Hagen Christian A. , Dugger Katie M. 
Published: December 2021

AbstractSpecies responses to disturbance influence their extinction risks. Greater sage‐grouse (Centrocercus urophasianus) are bioindicators of sagebrush ecosystem health and the loss of sagebrush (Artemisia spp.) due to wildfire, can cause long‐term declines in sage‐grouse populations and other sagebrush obligate species. We examined the demographic response of a greater sage‐grouse population following a mega‐wildfire using stochastic age‐structured female‐based matrix models over 6 years (2013–2018). Notably, chick survival (range = 0.18–0.38) and female survival (yearling range: 0.20–0.68; adult range: 0.27–0.75) were low compared to values reported for greater sage‐grouse in other parts of their distribution. Greater sage‐grouse displayed variation in demographic tactics after the fire; however, adult female survival explained most of the variation in λ during each year, which reflected a declining population in 3 of 6 years with more uncertainty observed in 2015 when populations may have been increasing, and 2017 and 2018, when populations may have been declining. The continued annual population decline observed since 2016 suggested there were additional strong environmental impacts that may have been compounded by the fire effects, prolonging recovery of greater sage‐grouse. Our results support others that reported negative effects to greater sage‐grouse demographics from broad‐scale fire and provide a baseline for understanding how this species responds to loss of sagebrush cover based on their life history strategy.