bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperhomocysteinemia Is Associated With Lipid Profiles and Lipid Ratio in Patients With Coronary Artery Disease
Authors: Wu Dong-Feng , Liao Qin-Chen , Lu Feng , Wang Zhou , Yu Kun , Deng Jin-Long 
Published: September 2021

Abstract
Objective: This study aimed to investigate the correlation of Hyperhomocysteinemia (HHcy) or serum homocysteine (Hcy) levels with lipid levels and lipid ratios in individuals with coronary artery disease(CAD).Methods: A total of 1646 subjects with suspected CAD were divided into CAD or control groups. Serum Hcy, total cholesterol(TC), triglycerides(TGs), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), apolipoprotein(Apo)AI and ApoB concentrations were detected.Results: Serum TC, LDL-C and ApoB in control subjects with HHcy were lower than those in individuals with normal Hcy, and serum HDL-C and ApoAI in CAD subjects with HHcy were lower than those in individuals with normal Hcy(P < 0.05). The correlation analysis showed that serum TGs, LDL-C, ApoAI and HDL-C were correlated with Hcy(P <0.05). There are different HHcy trends affecting the ratios of TC/HDL-C and LDL/HDL-C between the CAD and controls(Pinteraction for TC/HDL-C=0.025; Pinteraction for LDL/HDL-C=0.033). CAD patients with HHcy had a higher ratio of TC/HDL-C(P=0.022) and LDL/HDL-C(P=0.045) than those with normal Hcy, but in the controls, the subjects with HHcy exhibited a trend toward a decreased ratio of TC/HDL-C(P=0.481) and LDL/HDL-C(P=0.303).Conclusion: HHcy was related to the atherogenic lipid profile in patients with CAD. The lipid ratio is more suitable for assessing the effect of HHcy on CAD.
Reduced Regime of Glucocorticoids and Cyclophosphamide for Mild ANCA-Associated Renal Vasculitis May Delay Deterioration of Renal Function
Authors: Li Ziyang , Bao Jiwen , Yao Huanzhen , Wang Qin , Zhang Minfang , Gu Leyi , Ni Zhaohui , Wang Ling 
Published: September 2021

Abstract
ObjectivesTo compare the efficacy and safety of initial reduced-dose glucocorticoids combined with reduced-frequency cyclophosphamide and to determine risk predictors of end-stage renal disease in ANCA-associated vasculitis（AAV）patients with renal involvement which BVAS was less than 20.MethodsThis is a single-center retrospective cohort study that involved 58 patients who were newly diagnosed with ANCA-associated renal vasculitis. The efficacy and safety of reduced-frequency cyclophosphamide combined with initial reduced-dose glucocorticoids were compared using chi-square test. The cumulative probability to ESRD were estimated using the Kaplan–Meier method and compared using the log rank test. Potential variates were examined using multivariate Cox proportional hazard models to determine the risk predictors of end-stage renal disease.ResultsA total of 35 patients in the standard-dose glucocorticoids group and 23 in the reduced-dose glucocorticoids group were included. The average age of the included patients was 62.45±12.70 years, and the baseline serum creatinine was 251.35[155.53, 445] μmol/L. Nine patients (15.52%) developed ESRD within 24 months (7 Standard vs. 2 Reduced, P=0.035). Multivariate Cox regression model analysis proved that baseline serum creatinine (HR: 0.007, 95%CI: 2.48-39.48, P=0.014), infection rate within first 3 months (HR: 2.28, 95% CI: 2.14 45.27, P=0.003), persistent hematuria for more than 6 months (HR: 1.723, 95%CI: 0.043-0.738, P=0.017) were risk predictors of end-stage renal disease in ANCA-associated renal vasculitis.ConclusionThe regime of initial reduced-dose glucocorticoids combined with reduced-frequency cyclophosphamide is not inferior to the standard regimen in AAV patients with renal involvement which BVAS score was less than 20，and meantime the incidence of infection was significantly lowered. Patients had infection within first 3 months were at higher risk in development of ESRD. To reduce the incidence of infection and thus delay deterioration of renal function, the reduced-dose regime may be more appropriate than standard-dose regimen and can be used as an option in mild patients.
A semi-analytical elastic stress solution for circular rock stratum based on the theory of curved beam
Authors: BU wankui , XU Hui 
Published: September 2021

Abstract
The circular rock stratum are inevitably encountered in underground mining engineering, which causes waste of resources and dynamic instability. Based on the elastic theory of curved beam and finite-difference computation, a displacement function is presented in polar coordinates for solving two partial differential equations with the boundary conditions in mixed type in elastic, isotropic and homogeneous rock. A semi-analytical elastic stress solution for circular rock stratum is obtained according to the governing equation and stress components in terms of displacement function. The variations of stress distribution with different influencing factors are analyzed, which may lead to a better understanding of the stability of circular rock stratum after coal extractions. Finally, this semi-analytical elastic stress solution is applied to the fold structure in No.2502 mining area and points out the dangerous sites during coal extractions, which provides the basis of construction and safety in coal mine engineering.
Characterization of The Physicochemical Properties, Antioxidant Activity, And Antiproliferative Activity of Natural Melanin From S. Reiliana
Authors: Lu Ming , Xie Mengxi , Fu Xin , Yu Miao , Shi Taiyuan 
Published: September 2021

Abstract
This study aimed to characterize the physicochemical properties and stability of L-25 melanin extracted from Sporisorium reilianum (S. reiliana). The results showed that the maximum absorption wavelength of melanin was 215 nm. Reducing agents, heat, light, microwaving, oxidants, and common food additives did not affect the melanin. Additionally, it has a good metal stability except Mn2+. The IR spectra revealed the presence of O-H, N-H, C=O, and C=C bonds as well as carboxyl, alcohol hydroxyl, and phenolic hydroxyl groups and a pyran ring. L-25 melanin could be defined as DL-hydroxy phenylalanine (DOPA)-melanin. The antioxidant and antiproliferative were also measured. The melanin has a specific stability and high antioxidant activity, including a strong DPPH free radical scavenging ability, and protected damaged HepG2 cells by reducing reactive oxygen species, malondialdehyde, and lactate dehydrogenase content. In conclusion, S. reilianum represents a novel source of melanin, that could be applied to health food or food additives. Our results show that melanin from S. reilianum is a natural pigment with good stability that has a great prospect of development and application, providing a theoretical basis and methods for its further processing and development as a functional food.
Glecaprevir/ Pibrentasvir in the Treatment of Chronic Hepatitis C Patients – A Real-World Nationwide HCV Registry Program (TACR) in Taiwan
Authors: Huang Chung-Feng , Kuo Hsing-Tao , Chang Te-Sheng , Lo Ching-Chu , Hung Chao-Hung , Huang Chien-Wei , Chong Lee-Won , Cheng Pin-Nan , Yeh Ming-Lun , Peng Cheng-Yuan , Cheng Chien-Yu , Huang Jee-Fu , Bair Ming-Jong , Lin Chih-Lang , Yang Chi-Chieh , Wang Szu-Jen , Hsieh Tsai-Yuan , Lee Tzong-Hsi , Lee Pei-Lun , Wu Wen-Chih , Lin Chih-Lin , Su Wei-Wen , Yang Sheng-Shun , Wang Chia-Chi , Hu Jui-Ting , Mo Lein-Ray , Chen Chun-Ting , Huang Yi-Hsiang , Chang Chun-Chao , Huang Chia-Sheng , Chen Guei-Ying , Kao Chien-Neng , Tai Chi-Ming , Liu Chun-Jen , Lee Mei-Hsuan , Tsai Pei-Chien , Dai Chia-Yen , Kao Jia-Horng , Lin Han-Chieh , Chuang Wang-Long , Chen Chi-Yi , Tseng Kuo-Chih , Yu Ming-Lung 
Published: September 2021

Abstract
Background/AimsThe study evaluated the real-world treatment outcomes of Glecaprevir/pibrentasvir (GLE/PIB) including effectiveness, safety and healthcare resource utilization based on a nation-wide registry in Taiwan.MethodsThe Taiwan HCV Registry (TACR) is a nation-wide platform organized and supervised by the Taiwan Association for the Study of the Liver. Data were analyzed for patients treated with GLE/PIB, including 3,144 patients who had treatment outcome available. The primary endpoint was sustained virological response (SVR12, undetectable HCV RNA throughout 12 weeks of end-of-treatment). ResultsThe overall SVR12 rate was 98.9% (3110/3144), with 98.8%, 99.4% and 100% in patients receiving 8 weeks, 12 weeks, and 16 weeks of GLE/PIB respectively. The SVR12 rate in the treatment-naïve cirrhotic patients receiving 8 weeks of GLE/PIB was 98.2% (108/110). The most common AEs were fatigue (7.5%), pruritus (6.7%) and dizziness (1.5%). The mean number of outpatient visits during the GLE/PIB was 5.94 visits for patients treated with 8 weeks, significantly different from the patients treated with 12 weeks of GLE/PIB (6.90 visits). ConclusionsThe results support the effectiveness and safety of GLE/PIB treatment in real-world clinical practice, and provide further evidence that the shorter, 8-week GLE/PIB regimen is effective and cost-saving.
Risk Factor Analysis of Intravesical Recurrence After Laparoscopic Nephroureterectomy for Upper Tract Urothelial Carcinoma
Authors: Yanagi Masato , Hamasaki Tsutomu , Akatsuka JunJun , Endo Yuki , Takeda Hayato , Kondo Yukihiro 
Published: September 2021

Abstract
Background: One of the major concerns of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy is intravesical recurrence (IVR). The purpose of the present study was to investigate the predictive risk factors for IVR after laparoscopic nephroureterectomy (LNU) for UTUC.Methods: Clinicopathological and surgical information were collected from the medical records of 73 patients treated with LNU for non-metastatic UTUC, without a history of or concomitant bladder cancer. The association between IVR after LNU and clinicopathological and surgery-related factors, including preoperative urine cytology and pneumoperitoneum time, was analyzed using Cox proportional hazards regression models and the Kaplan–Meier method with log-rank test.Results: During the median follow-up time of 39.1 months, 18 (24.7%) patients had subsequent IVR after LNU. The 3- and 5-year IVR-free survival rates were 76.5% and 74.3%, respectively. In the multivariate Cox regression analysis, positive preoperative urine cytology (hazard ratio [HR]: 3.55; 95% confidence interval [CI]: 1.326–11.327; p=0.011) and prolonged pneumoperitoneum time of ≥ 210 min (HR: 3.40; 95% CI: 1.271–10.692; p=0.014) were independent prognostic factors for IVR-free survival. In patients with positive urine cytology, the Kaplan–Meier method with log-rank test revealed that the 3-year and 5-years IVR free survival rates were 46.3% and 39.7%, respectively, in patients with a prolonged pneumoperitoneum time of ≥ 210 min, which was significantly lower than that in their counterparts (76% and 76%, respectively, p=0.041).Conclusions: In UTUC patients with positive urine cytology, the occurrence of IVR is highly probable when the pneumoperitoneum time of LNU is prolonged (≥ 210 min). Strict follow-up after LNU is highly recommended for these patients.
Financial Burden and Health-seeking Behaviors Related to Chronic Diseases Under the National Health Insurance Scheme in Bolikhamxay Province, Lao PDR: a Cross-sectional Study
Authors: Ito Tomoo , Miyoshi Chiaki , Kounnavong Sengchanh 
Published: September 2021

Abstract
Background: Financial protection is a key dimension of universal health coverage. In 2016, Lao PDR implemented the National Health Insurance system covering the entire population of certain provinces. This cross-sectional study investigated households’ health-seeking behavior and their financial burden with chronic patients, post coverage. Method: The study was conducted in Bolikhamxay province from January 15 to February 13, 2019. In total, 487 households, selected via stratified random sampling, were surveyed, and questionnaire-based interviews conducted. Health care service utilization and financial burden were examined.Results: Totally, 370 households had at least one member with some type of self-reported health problem within the last 3 months prior to the interview, while 170 had at least one member with a chronic condition. More than 75% of the households accessed a health facility when a member experienced health problems. We observed that the prevalence of catastrophic health expenditure (health expenditure/income between 20% and 40%) was 25.1% (threshold of 20%) and 16.2% (threshold of 40%). Through logistic regression, we found that the major factors determining financial catastrophes owing to health problems were household members with chronic illness, hospitalization, household poverty status, family size (both 20% and 40% thresholds), visiting a private facility (20% threshold), and distance from provincial top referral hospital (40% threshold).Conclusions: The National Health Insurance system has positively impacted households’ access to health facilities. However, catastrophic health expenditure remains high, especially among chronic patients. Facilities under National Health Insurance should be strengthened to provide more services, including care for chronic conditions.
Optimizing Hybrid Metaheuristic Algorithm with Cluster Head to Improve Performance Metrics on the IoT
Authors: alazzam Malik bader , Alassery Fawaz 
Published: September 2021

Abstract
The Internet of Things (IoT) has subsequently been applied to a variety of sectors, including smart grids, farming, weather prediction, power generation, wastewater treatment, and so on. So if the Internet of Things has enormous promise in a wide range of applications, there still are certain areas where it may be improved. Designers had focused our present research on reducing the energy consumption of devices in IoT networks, which will result in a longer network lifetime. The far more suitable Cluster Head (CH) throughout the IoT system is determined in this study to optimize energy consumption. Whale Optimization Algorithm (WOA) with Evolutionary Algorithm (EA) is indeed a mixed meta-heuristic algorithm used during the suggested study. Various quantifiable metrics, including the variety of adult nodes, workload, temperatures, remaining energy, and a target value, were utilized IoT network groups. The suggested method then is contrasted to several cutting-edge optimization techniques, including the Artificial Bee Colony method, Neural Network, Adapted Gravity Simulated annealing. The findings show that the suggested hybrid method outperforms conventional methods.
Identification and characterization of a novel potyvirus infecting Paris yunnanensis
Authors: Lan Pingxiu , He Peng , Cao Mengji , Zhou Guohua , Chenrong Li , Tan Guanlin , Chen Xiaojiao , Yang Jie , Wei Taiyun , Li Fan 
Published: September 2021

Abstract
The complete genomic sequence of a novel potyvirus from Paris yunnanensis was determined by high-throughput sequencing then confirmed by Sanger sequencing. Its genomic RNA consists 9600 nucleotides (nt) excluding the 3’-terminal poly (A) tail, containing a typical large open reading frame (ORF) of potyviruses and encoding a putative polyprotein of 3098 amino acids (aa). Pairwise comparison analysis showed the virus shares sequence identity with other members of Potyvirus was 53.0–57.8% at genome sequence level, and 39.3–51.2% at polyprotein sequence level. Phylogenetic analysis indicated that the virus was clustered as a single clade within the genus Potyvirus both using nt and aa level. These results suggest that the virus should be considered as a distinct species within the genus Potyvirus, and it was tentatively named as “Paris mottle virus” (PaMoV).
Influence of CNTs, ZnO, Gd2O3 and SiO2 on Calcium Silicate Hydrate: A Raman spectroscopic study
Authors: Azeem Muhammad 
Published: September 2021

Abstract
Raman spectra are collated from the cement paste matrices of CNTs, ZnO, Gd2O3, and SiO2. The spectra show that CNTs do not take part in hydration process and therefore concentration of calcium silicate hydrate (CSH) is unchanged in CNT-OPC matrix. The metal oxides, on the other hand, have shown significant effects on the CSH concentration. The CSH concentration increases with the increase of ZnO weight percent in the matrix whereas spectra collected from Gd2O3 matrix shows the strongest CSH vibrational bands. Moreover, vibrational bands of CaCO3 also become weak in the matrices with Gd2O3. The addition of SiO2 however had opposite effects that is by increasing the weight percent of SiO2 in the matrix, the CSH concentration is decreased. Since CSH acts a glue in a binder, the study shows that its concentration can be controlled by adding foreign elements. Such binders are expected to show improved strength and durability.
Utilization of Radiation Therapy and Predictors of Noncompliance Among Syrian Refugees in Turkey
Authors: Sayan Mutlay , Eren Mehmet Fuat , Kotek Ayse , Kaplan Sedenay Oskeroglu , Duran Ozge , Cukurcayır Funda , Babalıoglu Ibrahim , Or Ozlem Derinalp , Ozturk Gul Aysen , Eroglu Celalettin , Teke Fatma , Kurtul Neslihan , Kutuk Tugce , Bicakci Beyhan Ceylaner , Senyurek Sukran , Aktan Meryem , Mamidanna Swati , Ohri Nisha , Haffty Bruce , Atalar Banu 
Published: September 2021

Abstract
BackgroundAccess to cancer care is a problem that continues to plague refugees displaced from their home countries. The turbulent political crisis in Syria, which has led to millions of refugees seeking asylum in Turkey, merits further attention. We aimed to study the rate of utilization of radiation therapy among Syrian refugees with cancer living in Turkey in an attempt to identify the contributing factors predictive of non-compliance with prescribed RT.MethodsIn this retrospective review of 14 institutional databases, Syrian refugee patients in Turkey with a cancer diagnosis from January 2015 to December 2018 who were treated with RT were identified. The demographic data, treatment compliance rates, and toxicity outcomes in these patients were surveyed. Variable predictors of noncompliance such as age, gender, diagnosis, geographic location, treatment length, and toxicity were studied. The association between these variables and patient noncompliance was determined.ResultsWe identified 10,537 patients who were diagnosed with cancer during the study period, of whom 1010 (9.6%) patients were treated with RT. Breast cancer (30%) and lung cancer (14%) were the most common diagnoses with up to 68% of patients diagnosed at an advanced stage (Stage III, IV). 20% of the patients were deemed noncompliant. Treatment with concurrent chemoradiotherapy (OR 1.61, 95% CI 1.06 – 2.46, p = 0.023) and living in a refugee camp (OR 3.62, 95% CI 2.43 – 5.19, p < 0.001) were associated with noncompliance. Age, gender and treatment length were not significantly associated with noncompliance.ConclusionsNoncompliance with radiotherapy among Syrian refugees in Turkey remains an area of concern with a multitude of factors contributing to these alarming numbers. Further studies to better ascertain the finer nuances of this intricately complex problem and a global combination of efforts can pave the way to providing a solution.
Lack of miRNA-17 family mediates high glucose-induced PAR-1 up-regulation in glomerular mesangial cells
Authors: Tang Zhuang-Zhuang , Gu Pan-Pan , An Xiao-Fei , Gou Ling-Shan , Liu Yao-Wu 
Published: September 2021

Abstract
Up-regulation of thrombin receptor protease-activated receptor 1 (PAR-1) is verified to contribute to chronic kidney diseases, including diabetic nephropathy, however, the mechanisms are still unclear. In this study, we investigated the effect of PAR-1 on high glucose-induced proliferation of human glomerular mesangial cells (HMCs), and explored the mechanism of PAR-1 up-regulation from alteration of microRNAs. We found that high glucose stimulated proliferation of the mesangial cells whereas PAR-1 inhibition with vorapaxar attenuated the cell proliferation. Moreover, high glucose up-regulated PAR-1 in mRNA level and protein expression while did not affect the enzymatic activity of thrombin in HMCs after 48 h culture. Then high glucose induced PAR-1 elevation was likely due to the alteration of the transcription or post-transcriptional processing. It was found that miR-17 family members including miR-17-5p, -20a-5p, and − 93-5p were markedly decreased among the eight detected microRNAs only in high glucose-cultured HMCs, but miR-129-5p, miR-181a-5p, and miR-181b-5p were markedly decreased in both high glucose-cultured HMCs and osmotic press control compared with normal glucose culture. So miR-20a was selected to confirm the role of miR-17 family on PAR-1 up-regulation, finding that miR-20a-5p overexpression reversed the up-regulation of PAR-1 in mRNA and protein levels induced by high glucose in HMCs. In summary, our finding indicated that PAR-1 up-regulation mediated proliferation of glomerular mesangial cells induced by high glucose, and deficiency of miR-17 family resulted in PAR-1 up-regulation.
Impact of covid19 lockdown on sleep quality and acute psychiatric morbidity in medical students in Sudan.
Authors: Altayeb Albashir A. , altayeb Batool A. , Ibrahim Mohammed E. , Abdalgalil Amira Siddig 
Published: September 2021

Abstract
Introduction: The severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) is an emerging infection causing a widely spread pandemic of Coronavirus disease 2019 (COVID-19). The current COVID-19 pandemic is promoting fear of falling sick, dying, helplessness, and stigma. Urgent and timely understanding of sleep quality and mental health status is needed to help the community. Our investigation designed to assess the degree of sleep disturbance and psychological impact of the lockdown among medical students at university of Khartoum.Objectives: this study conducted to assess the impact of covid-19 lockdown on sleep quality and acute psychiatric morbidities among medical students at university of Khartoum.Method: Institutional based cross sectional study was conducted among 326 participants from Khartoum university, faculty of medicine. Study participants were determined by two steps, stratified sampling followed by systematic sampling techniques. Data was collected using standardized questionnaire, entered and analyzed using Statistical Package for Social Science (SPSS) software version 25.Results: out of the total 326 participants 211(64.7%0 were females, and 115(35.35) were males. 92 (28.2%) form the participants were good sleepers and 234 (71.8%) were poor sleepers, the prevalence of moderate to severe anxiety and depression in the participants was found 19.4%, 35.9% respectively. There was correlation between having poor sleep quality and depression among the participants.Conclusion: This study found that there is negative impact of the covid-19 lockdown on medical students, which we found that two thirds of the participants are poor sleepers with a predominance of the female gender among them, One third of the participants had moderate to severe depression which also affects the female more than the males and the junior students more than the seniors, Fifth of the participants had moderate to severe anxiety which affect both gender equally but it did affect the junior students more than the seniors.