bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prohibition to approach a certain distance and / or to certain persons, to be in a certain place as a measure of a criminal nature (on the example of the Penal Code of the Republic of Poland)
Authors: Cheban Olesia Mykhailivna 
Published: December 2021

The article analyzes the provisions of the Polish Penal Code in terms of establishing a ban on being in certain environments or places, contact with certain people, approaching certain persons or leaving a special place of residence without the consent of the court, as a kind of criminal measure. Sais about prohibitions to hold a specific position, engage in a certain profession or carry out certain types of economic activity. In the Polish Penal Code, the analyzed prohibitions apply to the perpetrator in the case of an intentional crime combined with violence, and are binding from the entry into force of the court decision in the criminal case.
It is known that in Ukraine there are special measures to combat domestic violence in the form of an urgent injunction against the offender and a restrictive injunction against the offender. In its legal positions, the Supreme Court revealed the essence (legal nature) of the restrictive order as a temporary measure of restraint, which is not a measure of punishment for a person. The Supreme Court also justified the legitimacy of the restraining order in the form of a temporary prohibition on the offender to stay and approach real estate, even if he is its co-owner, because he committed domestic violence against relatives.
Measures in the restrictive order in relation to the offender are taken to decide on the qualification of his actions and the decision on him in criminal proceedings. However, the danger of continuing or re-committing domestic violence, the occurrence of serious consequences for the victim remains after the case in court. Therefore, prohibitions to approach the victim at a certain distance, to be in a place of residence should not lose their force and relevance, and in turn, begin to play a preventive role as a measure of criminal law.
The author proved the importance of expanding the list of «other measures of a criminal nature» by including a ban on approaching a certain distance and / or to certain persons, a ban on being in a certain place in Section XIV of the General Part of the Criminal Code of Ukraine.
Sistem Pendukung Keputusan menggunakan Simple Additive Weighting dalam Pemberian Reward Karyawan
Authors: Marfuah Marfuah , Adam Steffi 
Published: December 2021

Reward dapat meningkatkan semangat kerja bagi para karyawan untuk terus memberikan kinerja yang lebih baik. Sehingga para karyawan yang memiliki kinerja yang baik dapat di kategorikan sebagai karyawan teladan. Pada PT. XYZ yang berada di kota Batam, selama ini dalam pengambilan keputusan terkait pemberian reword belum didukung dengan suatu sistem yang terkomputerisasi. Sedangkan dalam proses penilaian tersebut terdapat beberapa kriteria yang digunakan untuk pemberian reword kepada karyawan. Sehingga, untuk mendukung penilain yang subjektif dari perusahaan terhadap karyawan maka, sangat penting menggunakan sistem pendukung keputusan dengan menggunakan metode simple additive weigting (SAW). Penggunaan metode tersebut dengan memberikan pembobotan terhadap kriteria yang digunakan. Adapun kriteria yang digunakan yaitu target transaksi, absen dan pengambilan cuti. Berdasarkan kriteria dan alternatif yang ada, setelah dilakukan pembobotan dan perhitungan didapatkan 3 rengking teratas dalam pemberian reword yaitu v7 nilai 5,5,, v1 nilai 5,3 dan v8 dengan nilai 5.
In situ treatment technologies for pit latrines to mitigate groundwater contamination by fecal pathogens: a review of recent technical advances
Authors: Saxena Shray , Den Walter 
Published: December 2021

Abstract
On-site sanitation systems such as pit latrines are extensively used around the world, while there is a growing number of evidence documenting the impact of pit latrines on groundwater quality that may affect human health. Hence, this paper summarizes the various safe-sanitation technologies by broadly categorizing them into fecal pathogen disinfection methods (anaerobic digestion, chemical disinfection, biological additives, solar pasteurization and vermicomposting) and capturing methods (pit lining and permeable reactive barriers, the latter of which simultaneously capture and sanitize fecal sludge in pit latrines). While some of the reviewed technologies have been widely practiced for mitigating microbial contamination of the groundwater, others are still in the early stage of commercialization and field validation. Though there are challenges to the selection and adoption of the most appropriate technology, this paper discusses the readiness of each technology as a stand-alone fecal sludge management solution.
Acceptability of reclaimed municipal wastewater in cities: evidence from India's National Capital Region
Authors: Neha  , Kansal Arun 
Published: December 2021

AbstractWillingness to reuse reclaimed municipal wastewater was ascertained through a questionnaire completed by 424 respondents, opinions of 17 experts, and interviews with 15 farmers. Information was collected to assess their knowledge of water scarcity and to determine the influence of demographics, correlation to perceived risk, willingness, challenges, and barriers related to the acceptance of reclaimed water. Most respondents were receptive to the idea of using it for purposes other than drinking, and ‘water conservative’ individuals were inclined towards using it even for drinking. Farmers were concerned about its quality and implications for the health of using it for irrigation. Effective communication between authorities and end-users can promote the idea of reusing greywater and reclaimed water for domestic use, and, eventually, for drinking. These findings will be useful in developing an integrated, practical, and strategic framework for treating wastewater for reuse in other cities not only in India but also in other developing countries.
Comparison of commercial disinfectants and an in loco-produced solution: free residual chlorine decay in human supply waters
Authors: Belmino da Silva George Antonio , dos Santos Whelton Brito , de Almeida Lopes Thiago Santos , Ferreira Weruska Brasileiro , Lima Rodrigues Andréa Carla 
Published: December 2021

Abstract
The disinfection process is used in the treatment of water for human supply to promote sanitary safety and provide users with drinking water that meets potability standards. Thus, it is necessary to sustain a minimal concentration of free residual chlorine (FRC) throughout the entire distribution system. The present study investigated the decay process of FRC concentration in water destined for human supply. The decay was evaluated in bench-scale testing, using sodium hypochlorite, calcium hypochlorite, sodium dichloroisocyanurate (organic chlorine) as disinfectant agents, and also an alternative disinfectant solution (ADS) produced in loco, with oxidizing and disinfectant properties, which is being used in Brazilian sanitation industry. To evaluate the decay, four models were fitted: first-order, nth-order, limited first-order and parallel first-order, hence determining the corresponding parameters which describe the decay speed of the FRC concentration in water. Achieved results demonstrated that all models were statistically significant and predictive. However, the parallel first-order model produced the best fit. Regarding the evaluated disinfectants, there was preeminence of the ADS solution when compared to the others, since it imparted a higher FRC over time, a behavior indicated by lower values for reaction rate constant in all models and when compared to other disinfectants used in this study.
Discovery of Novel Small Molecule HDAC1, 2, 3 Inhibitors -- Combined Receptor-Based and Ligand-Based Virtual Screening Strategy
Authors: Wu Yi , Zhang Bo , Dong Xiaowu , Ma Shenglin , Hu Shengquan 
Published: December 2021

Aims:This study aims to investigate and validate the potential drug target to HDAC1.Background:Human histone deacetylase 1 (HDAC1) can catalyze the deacetylation of histones belonging to the family of human histone deacetylases (HDACs). Amide hydrolase HDAC1 plays a key role in the development of many serious cancers such as prostate cancer, gastric cancer, lung cancer, esophageal cancer, colon cancer, and breast cancer. Therefore, HDAC1 inhibitors, promoting the transcription of a series of key genes such as the p53 gene and inhibiting the development of cancer through various downstream mechanisms, have great potential for the treatment of cancer.Objective:The objective of this study is to discover new skeleton HDAC1 inhibitors efficiently and conveniently with therapeutic potential for cancer.Method:Based on the crystal structure of HDAC1, through the combination of receptor-based and ligand- based virtual screening from the commercial compound library, the top-ranked compounds are selected for purchase through binding modes analysis, and their activities were verified through in vitro HDAC1 inhibitory biological experiments.Results:Based on LeDock, 5ICN showed good distinguishing ability and was used as the receptor. According to the results of the LeDock docking scoring from receptor-based virtual screening, 69 compounds with binding energy less than -7.5 kcal/mol were obtained and used for ligand-based virtual screening. A total of 21 novel compounds with high potential HDAC1 inhibitory activity were collected by combining the similarity searching (NN) and the multinomial Naive Bayes machine learning model (NB) methods. Through binding modes analysis, 10 compounds with different structures with potential HDAC1 inhibitory activity were selected and screened HDAC1 inhibitory in vitro. May267 showed moderate HDAC1 inhibitory activity, and the inhibition rate was 48% at a concentration of 20 μM.Conclusion:This study discovers novel small molecule HDAC1 inhibitors by combined receptor-based and ligand-based virtual screening strategy, which provides an efficient method for the discovery of other small molecule drugs. May267 shows moderate HDAC1 inhibitory activity, which can be further optimized as a lead compound. However, it still has the problem of poor kinase selectivity to be solved.
Synthesis and Evaluation of Bis-Schiff Bases of Carbohydrazide as Antioxidant and Cytotoxic Agents
Authors: Iqbal Sarosh , Kiran Shumaila , Perveen Shahida , Malik Rizwana , Taha Muhammad , Khan Khalid Mohammed , Perveen Shahnaz , Choudhary M. Iqbal 
Published: December 2021

Introduction:
Antioxidants are known to prevent oxidative stress-induced damage to the
biomolecules and thus, delay the onset of cancers and many age-related diseases. Therefore, the development
of novel and potent antioxidants is justified.

Method:
During this study, we synthesized symmetrical Bis-Schiff bases of carbohydrazide 1-27,
and evaluated their in vitro antioxidative activity and cytotoxic activity.

Results:
Among synthesized compounds, six compounds 20 (IC50 = 12.89 ± 0.02 μM), 16 (IC50 =
14.32 ± 0.43 μM), 17 (IC50 = 18.52 ± 0.83 μM), 19 (IC50 = 22.84 ± 0.62 μM), 24 (IC50 = 35.1 ± 0.82
μM) and 15 (IC50 = 40.03 ± 1.06 μM) showed an excellent 2,2-diphenyl-1-picrylhydrazyl (DPPH)
radical scavenging activity, better than the standard butylatedhydroxyanisole (BHA) (IC50 = 44.6 ±
0.6 μM). Likewise, two compounds 16 (IC50 = 4.3 ± 1.3 μM) and 20 (IC50 = 6.6 ± 1.6 μM) showed
oxidative burst scavenging activity better than the standard drug ibuprofen (IC50 = 11.2 ± 1.9 μM).
Some synthesized compounds showed good to moderate toxicity against prostate cancer (PC-3) cell
lines.

Conclusion:
This study has identified potent antioxidants and good cytotoxic agents with the potential
to further investigate.
Mannich Bases: Centrality in Cytotoxic Drug Design
Authors: Bhilare Neha V. , Marulkar Vinayak S. , Shirote Pramodkumar J. , Dombe Shailaja A. , Pise Vilas J. , Salve Pallavi L. , Biradar Shantakumar M. , Yadav Vishal D. , Jadhav Prakash D. , Bodhe Anjali A. , Borkar Smita P. , Ghadge Prachi M. , Shelar Pournima A. , Jadhav Apurva V. , Godse Kirti C. 
Published: December 2021

:
Mannich bases identified by Professor Carl Mannich have been the most extensively explored
scaffolds for more than 100 years now. The versatile biological roles that they play have promoted
their applications in many clinical conditions. The present review highlights the application of
Mannich bases as cytotoxic agents, categorizing them into synthetic, semisynthetic, and prodrugs
classes, and gives an exhaustive account of the work reported in the last two decades. The methods
of synthesis of these cytotoxic agents, their anti-cancer potential in various cell lines, and promising
leads for future drug development have also been discussed. Structure-activity relationships, along
with the targets on which these cytotoxic Mannich bases act, have been included as well.
TP-MV: Therapeutic Peptides Prediction by Multi-view Learning
Authors: Yan Ke , Lv Hongwu , Wen Jie , Guo Yichen , Liu Bin 
Published: December 2021

Background:
Therapeutic peptide prediction is critical for drug development and therapy. Researchers have been studying this essential task, developing several computational methods to identify different therapeutic peptide types.

Objective:
Most predictors are the specific methods for certain peptides. Currently, developing methods to predict the presence of multiple peptides remains a challenging problem. Moreover, it is still challenging to combine different features to make the therapeutic prediction.

Method:
In this paper, we proposed a new ensemble method TP-MV for general therapeutic peptide recognition. TP-MV is developed using the stacking framework in conjunction with the KNN, SVM, ET, RF, and XGB. Then TP-MV constructs a multi-view learning model as meta-classifiers to extract the discriminative feature for different peptides.

Results:
In the experiment, the proposed method outperforms the other existing methods on the benchmark datasets, indicating that the proposed method has the ability to predict multiple therapeutic peptides simultaneously.

Conclusion:
The TP-MV is a useful tool for predicting therapeutic peptides.
Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model
Authors: Yamazaki Hiroshi , Kamiya Yusuke , Miura Tomonori , Kato Airi , Murayama Norie , Shimizu Makiko 
Published: December 2021

Aim:The main aim of the current study was to obtain forward dosimetry assessments of pyrrolizidine alkaloid senkirkine plasma and liver concentrations by setting up a human physiologically based pharmacokinetic (PBPK) model based on the limited information available.Background:The risks associated with plant-derived pyrrolizidine alkaloids as natural toxins have been assessed.Objective:The pyrrolizidine alkaloid senkirkine was investigated because it was analyzed in a European transcriptomics study of natural hepatotoxins and in a study of the alkaloidal constituents of traditional Japanese food plants Petasites japonicus. The in silico human plasma and liver concentrations of senkirkine were modeled using doses reported for acute-term toxicity in humans.Methods:Using a simplified PBPK model established using rat pharmacokinetic data, forward dosimetry was conducted. Since in vitro rat and human intrinsic hepatic clearances were similar; an allometric scaling approach was applied to rat parameters to create a human PBPK model.Results:After oral administration of 1.0 mg/kg in rats in vivo, water-soluble senkirkine was absorbed and cleared from plasma to two orders of magnitude below the maximum concentration in 8 h. Human in silico senkirkine plasma concentration curves were generated after virtual daily oral administrations of 3.0 mg/kg senkirkine (the dose involved in an acute fatal hepatotoxicity case). A high concentration of senkirkine in the culture medium caused in vitro hepatotoxicity as evidenced by lactate dehydrogenase leakage from human hepatocyte-like HepaRG cells.Conclusion:Higher virtual concentrations of senkirkine in human liver and plasma than those in rat plasma were estimated using the current rat and human PBPK models. Current simulations suggest that if P. japonicus (a water-soluble pyrrolizidine alkaloid-producing plant) is ingested daily as food, hepatotoxic senkirkine could be continuously present in human plasma and liver.
A Narrative Review on Dialectical Behavior Therapy for Patients
with Depressive Difficulties
Authors: Saini Aryendu Kumar , Wal Pranay , Wal Ankita , Pal Rashmi Saxena , Verma Om Prakash 
Published: December 2021

Background:
Dialectical behavior therapy (DBT) is a type of cognitive
behavioral therapy (CBT) that was earlier intended to treat only patients
with borderline personality disorder (BPD), but researchers have found DBT to
treat several psychological disorders, including depression.

Aim:
The article aims to review the clinical shreds of evidence regarding the use
of DBT to treat depression.

Methods:
PubMed literature search was done by applying the year filter range,
2010 to 2021. Another filter applied was “Randomized controlled trial”, so that
the strength of evidence could be enhanced. The keywords used were “Dialectical
Behavior Therapy” AND “Depression”.

Results:
33 articles were found, out of which only 20 relevant articles were reviewed.
DBT was found to alleviate depressive symptoms associated with different
psychological disorders like bipolar disorder and BPD but the number of
studies that validated the aforementioned were less than those studies which
showed that DBT had no significant effect on the patients with depressive difficulties.
The long-term effect of DBT for treating depression is under suspect, as
studies showed that DBT got ineffective during the follow-ups.

Conclusion:
DBT shows benefits in depression, but further studies are still required
to validate this concretely as DBT did not show a significant effect when
compared to its control counterparts. There is much need for future studies which
can evaluate the long-term efficacy of DBT in depression, which is another challenging
area because follow-up data did not favor DBT.
Effect of Anger Management Education on Aggression in Bipolar
Disorder Hospitalized Patients: A Pilot Study
Authors: Sadeghian Efat , Rezai Hossein , Shamsaei Farshid , Ghafari Mohammad Ebrahim 
Published: December 2021

Background:
Aggression is one of the symptoms of bipolar disorder.
This expression can be associated with negative personal and social effects.

Objective:
This study aimed to determine the effect of anger management education
on aggression in bipolar disorder.

Method:
This semi-experimental study with a repeated measures design was
conducted in Hamadan, Iran, 2018. Fifty-two bipolar type-1 disorder patients
were randomly selected from the Psychiatric Ward of Farshian Hospital through
the convenience sampling method. The anger management education intervention
included four sessions. Also, the State-Trait Anger Expression Inventory-2
(STAXI-2) was completed by the subjects before, immediately, and two weeks
after the educational intervention. Data analysis was performed in SPSS16, using
Mauchly’s sphericity test and the least significant difference.

Results:
The mean aggression score was 61.38±11.59 before the intervention,
which reduced to 27.18±8.61 and 18.86±6.45 immediately and two weeks after
the intervention, respectively. The repeated measures test showed that the decreasing
trend of scores was statistically significant (P<0.001). Moreover, pairwise
comparison of study stages demonstrated a significant difference between
the first and second stages (P<0.001) and the second and third stages (P<0.001).

Conclusion:
Anger management education reduced the level of aggression in
bipolar type-1 disorder. Therefore, it can be incorporated into nursing care programs.

Clinical Trial Registration number:
The study is registered in Iranian Registry
of Clinical Trials (IRCT2017052133378N2).
Pengaruh Penerapan Pembelajaran Blended Learning terhadap Hasil Belajar Siswa
Authors: Hendra Zulma , Yunita Alfi , Mardiyah Ainil 
Published: December 2021

ABSTRACT This study aims to determine the effect of the application of blended learning on the learning outcomes of class X MIA students at SMA PGRI 2 Padang. This study used a pre-experimental design in the form of a One-Shot Case Study by taking research subjects by Purposive Sampling. The sample of this research was the students of class X MIA. This study used descriptive questions as a final test instrument. The data analysis technique used in this research was a t-test. Based on the data collection techniques and data analysis carried out, it was obtained that tcount = 1.81 and ttable = 1.68, because tcount > ttable, then reject H0 at a significant level of 0.05 so it can be concluded that there is an effect of applying blended learning on studensts’ learning outcomes of class X MIA at SMA PGRI 2 Padang. Keywords: Blended Learning, Learning Outcomes
Peranan Guru Sejarah dalam Pemahaman Wawasan Kebangsaan pada Siswa Kelas XI IPS 1 SMA Negeri 12 Sijunjung
Authors: Klismen Juli Adek , Kaksim Kaksim , Meldawati Meldawati 
Published: December 2021

Instilling national values in schools is one of the efforts to shape student into citizens with character, because education can prepare the youger generation to play a role in the life of the nation in the future. However, in reality, students are still found in schools who do not understand ther country and nation. Thmselves and lack discipline. Phenomena that occur in schools, are still found by students who are late for the ceremony. National insight becomes important to be delevoped, because the sense of nationality as a manifestation of a sense of love for the homeland, in turn raises our awareness of the value and value of a sense of unity and nationality. So the conclusion that the researcher can convey is that the role of the history teache understanding national insightis very important and the history teacher can explain to students in clas XI IPS 1, and the role of the teacher is clearly visible after the researcher conducted interviews with students with a lot of knowledge about it, so the final conclusion that researchers got was that the role of history teachers was important in understanding national insight
Caracterización energética y determinación del potencial de generación eléctrica con tecnologías termoquímicas a partir de residuos degradables en Santiago de los Caballeros (República Dominicana)
Authors: Cuervo Julián , Betances Margarita , Peréz Esclaudys 
Published: December 2021

Este artículo presenta resultados donde se caracteriza energéticamente la fracción degradable de los residuos domésticos mediante la prueba de poder calorífico, además se determinó el potencial de generación eléctrica de esta fracción con tecnologías termoquímicas en un caso de estudio para la ciudad de Santiago de los Caballeros, República Dominicana. De acuerdo con los resultados, el poder calorífico promedio arrojó un valor de 9.337,6 kJ·kg-1. El valor más alto fue obtenido por los residuos de jardinería 10.560,6 kJ·kg-1. Seguido por los residuos de alimentos 10.385,4 kJ·kg-1. Los desechos de madera, cartón y papel arrojaron 9.875,0 kJ·kg-1, 9.227,4 kJ·kg-1 y 6.639,7 kJ·kg-1, respectivamente. El potencial de generación bruta de electricidad por día con respecto a los desechos orgánicos alcanzó un máximo de 308,8 MWh por día a través de la Gasificación de Ciclo Combinado (GCC).