bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast Arterial Calcifications on Mammography: A Survey of Practicing Radiologists
Authors: Collado-Mesa Fernando , Yepes Monica M , Arheart Kristopher 
Published: April 2021

Abstract

Objective
To explore current practice patterns of reporting and issuing recommendations based on the presence of breast arterial calcifications on mammography and existing knowledge of their prevalence and associated factors.

Methods
An online anonymous 19-question survey was distributed to 2583 practicing radiologists who were members of the Society of Breast Imaging. Questions covered demographics, breast imaging training, practice type, and knowledge regarding the epidemiology and potential clinical significance of breast arterial calcifications detected on mammograms. Differences between groups were calculated using the chi-square test or Fisher exact test. An α level of 0.05 was used to determine statistical significance.

Results
Response rate was 22% (364/1662). The median age of respondents was 51 years (range: 29–76) and most were female (248/323, 77%). The most prevalent characteristics among respondents were as follows: 69% (223/323) had completed a breast imaging fellowship, 55% (179/323) were in private practice, 49% (158/323) practiced dedicated breast imaging, and 38% (124/323) had been in practice for more than 20 years. The prevalence of breast arterial calcifications was correctly estimated to be 1%–30% by 39% (125/323) of respondents. Most respondents correctly recognized the growing evidence of an association between breast arterial calcifications and coronary artery disease (275/323, 85%). However, only 15% (48/323) always reported the presence of these calcifications, and of those who report them at any time, only 0.7% (2/274) always issued recommendations.

Conclusion
There are differences in both knowledge of the epidemiology of breast arterial calcifications and practices around their reporting amongst breast radiologists.
Association of Health-Care System With Prostate Cancer-Specific Mortality in African American and Non-Hispanic White Men
Authors: Klebaner Daniella , Courtney P Travis , Garraway Isla P , Einck John , Kumar Abhishek , Martinez Maria Elena , McKay Rana , Murphy James D , Parada Humberto , Sandhu Ajay , Stewart Tyler , Yamoah Kosj , Rose Brent S 
Published: April 2021

Abstract

Background
Disparities in prostate cancer-specific mortality (PCSM) between African American and non-Hispanic White (White) patients have been attributed to biological and systemic factors. We evaluated drivers of these disparities in the Surveillance, Epidemiology, and End Results (SEER) national registry and an equal-access system, the Veterans Health Administration (VHA).

Methods
We identified African American and White patients diagnosed with prostate cancer between 2004 and 2015 in SEER (n = 311 691) and the VHA (n = 90 749). We analyzed the association between race and metastatic disease at presentation using multivariable logistic regression adjusting for sociodemographic factors and PCSM using sequential competing-risks regression adjusting for disease and sociodemographic factors.

Results
The median follow-up was 5.3 years in SEER and 4.7 years in the VHA. African American men were more likely than White men to present with metastatic disease in SEER (adjusted odds ratio = 1.23, 95% confidence interval [CI] = 1.17 to 1.30) but not in the VHA (adjusted odds ratio = 1.07, 95% CI = 0.98 to 1.17). African American vs White race was associated with an increased risk of PCSM in SEER (subdistribution hazard ratio [SHR] = 1.32, 95% CI = 1.10 to 1.60) but not in the VHA (SHR = 1.00, 95% CI = 0.93 to 1.08). Adjusting for disease extent, prostate-specific antigen, and Gleason score eliminated the association between race and PCSM in SEER (aSHR = 1.04, 95% CI = 0.93 to 1.16).

Conclusions
Racial disparities in PCSM were present in a nationally representative registry but not in an equal-access health-care system, because of differences in advanced disease at presentation. Strategies to increase health-care access may bridge the racial disparity in outcomes. Longer follow-up is needed to fully assess mortality outcomes.
Video-assisted thoracoscopic surgery lobectomy and en bloc resection of the chest wall with incision of the costovertebral joints for non-small cell lung cancer
Authors: Yamamoto Shinichi , Sogabe Masaya , Endo Shunsuke 
Published: April 2021

Abstract
We describe a case of lung lobectomy and resection of the rib neck and head in a lung cancer patient with an invasion of the chest wall. The tumor was located in the upper lobe, adjacent to the neck of the third rib. We performed a right upper lobectomy and en bloc resection of the third rib, including the rib neck and head, by video-assisted thoracoscopic surgery with an additional 6 cm posterior incision along the right paravertebral line. The costovertebral joint incision procedure is a useful technique to ensure tumor-free margins in cases where the tumor is located close to the rib’s neck and head.
An analysis of the writing of ‘suicide cult’ members
Authors: Hodges Duncan , Paxton-Fear Katie 
Published: April 2021

Abstract
The infamous ‘Heaven’s Gate cult’ committed a mass suicide in 1995 believing members of the group would achieve salvation through bodily transformation and departure aboard UFOs. The group left a large volume of writing available as a book and a website which outlined their belief structure. This writing, largely by the group’s leaders Ti and Do, is supplemented by ‘exit statements’ written by the group members. We analysed these writings and demonstrated how the texts evolve from accessible texts for recruiting individuals into the group through more complex texts for cementing the belief structure and reinforcing the ingroup. We also identify differences in the ‘exit statements’ that demonstrate the ideas and concepts that gained traction with the group members.
X-ray binary accretion states in active galactic nuclei? Sensing the accretion disc of supermassive black holes with mid-infrared nebular lines
Authors: Fernández-Ontiveros Juan A , Muñoz-Darias Teo 
Published: April 2021

ABSTRACT
Accretion states, which are universally observed in stellar mass black holes in X-ray binaries, might be expected in active galactic nuclei (AGN). This is the case at low luminosities, when the jet–corona coupling dominates the energy output in both populations. Previous attempts to extend this framework to a wider AGN population have been extremely challenging due to heavy hydrogen absorption of the accretion disc continuum and starlight contamination from the host galaxies. We present the luminosity–excitation diagram (LED), based on the [O iv]25.9 μm and [Ne ii]12.8 μm mid-infrared nebular line fluxes. This tool enables to probe the accretion disc contribution to the ionizing continuum. When applied to a sample of 167 nearby AGN, the LED recovers the characteristic q-shaped morphology outlined by individual X-ray binaries during a typical accretion episode, allowing us to tentatively identify the main accretion states. The soft state would include broad-line Seyferts and about half of the Seyfert 2 population, showing highly excited gas and radio-quiet cores consistent with disc-dominated nuclei, in agreement with previous studies. The hard state mostly includes low-luminosity AGN ($\lesssim 10^{-3}\, \rm {L_{Edd}}$) characterized by low-excitation radio-loud nuclei and a negligible disc contribution. The remaining half of Seyfert 2 nuclei and the bright LINERs show low excitation at high accretion luminosities and could be identified with the bright hard and intermediate states. Their hosts show ongoing star formation in the central kiloparsecs. We discuss the above scenario, its potential links with the galaxy evolution picture, and the possible presence of accretion state transitions in AGN, as suggested by the growing population of changing-look quasars.
FACT interacts with Set3 HDAC and fine-tunesGAL1transcription in response to environmental stimulation
Authors: Leng He , Liu Shaofeng , Lei Yang , Tang Yuantao , Gu Shijia , Hu Jiazhi , Chen She , Feng Jianxun , Li Qing 
Published: April 2021

AbstractThe histone chaperone facilitates chromatin transactions (FACT) functions in various DNA transactions. How FACT performs these multiple functions remains largely unknown. Here, we found, for the first time, that the N-terminal domain of its Spt16 subunit interacts with the Set3 histone deacetylase complex (Set3C) and that FACT and Set3C function in the same pathway to regulate gene expression in some settings. We observed that Spt16-G132D mutant proteins show defects in binding to Set3C but not other reported FACT interactors. At the permissive temperature, induction of the GAL1 and GAL10 genes is reduced in both spt16-G132D and set3Δ cells, whereas transient upregulation of GAL10 noncoding RNA (ncRNA), which is transcribed from the 3′ end of the GAL10 gene, is elevated. Mutations that inhibit GAL10 ncRNA transcription reverse the GAL1 and GAL10 induction defects in spt16-G132D and set3Δ mutant cells. Mechanistically, set3Δ and FACT (spt16-G132D) mutants show reduced histone acetylation and increased nucleosome occupancy at the GAL1 promoter under inducing conditions and inhibition of GAL10 ncRNA transcription also partially reverses these chromatin changes. These results indicate that FACT interacts with Set3C, which in turn prevents uncontrolled GAL10 ncRNA expression and fine-tunes the expression of GAL genes upon a change in carbon source.
A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)
Authors: Rose Louise , Burry Lisa , Agar Meera , Campbell Noll L. , Clarke Mike , Lee Jacques , Marshall John C. , Devlin John W. , Blackwood Bronagh , Needham Dale M. , Siddiqi Najma , Page Valerie ,   for the Del-COrS Group
Published: April 2021

OBJECTIVES:
Delirium in critically ill adults is highly prevalent and has multiple negative consequences. To-date, trials of interventions to prevent or treat delirium report heterogenous outcomes. To develop international consensus among key stakeholders for a core outcome set for future trials of interventions to prevent and/or treat delirium in critically ill adults.

DESIGN:
Core outcome set development, as recommended by the Core Outcome Measures in Effectiveness Trials Handbook. Methods of generating items for the core outcome set included a systematic review and qualitative interviews with ICU survivors and family members. Consensus methods include a two-round web-based Delphi process and a face-to-face meeting using nominal group technique methods.

SUBJECTS:
International representatives from three stakeholder groups: 1) clinical researchers, 2) ICU interprofessional clinicians, and 3) ICU survivors and family members.

SETTING:
Telephone interviews, web-based surveys, and a face-to-face consensus meeting held at the 2019 European Delirium Association’s annual meeting in Edinburgh, Scotland.

INTERVENTION:
None.

MEASUREMENTS AND MAIN RESULTS:
Qualitative interviews with 24 ICU survivors and family members identified 36 potential outcomes; six were additional to the 97 identified from the systematic review. After item reduction, 32 outcomes were presented in Delphi Round 1; 179 experts participated, 38 ICU survivors/family members (21%), 100 clinicians (56%), 41 researchers (23%). Three additional outcomes were added to Round 2; 134 Round 1 participants (75%) completed it. Upon conclusion of the consensus building processes, the final core outcome set comprised seven outcomes: delirium occurrence (including prevalence or incidence); delirium severity; time to delirium resolution; health-related quality of life; emotional distress (i.e., anxiety, depression, acute and posttraumatic stress); cognition (including memory); and mortality.

CONCLUSIONS:
This core outcome set, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in critically ill adults.
Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial*
Authors: Bennett-Guerrero Elliott , Romeiser Jamie L. , Talbot Lillian R. , Ahmed Tahmeena , Mamone Linda J. , Singh Sunitha M. , Hearing Janet C. , Salman Huda , Holiprosad Dishaw D. , Freedenberg Alex T. , Carter Jason A. , Browne Nicholas J. , Cosgrove Megan E. , Shevik Margaret E. , Generale Laura M. , Andrew Margaret A. , Nachman Sharon , Fries Bettina C. 
Published: April 2021

OBJECTIVES:
Four peer-reviewed publications have reported results from randomized controlled trials of convalescent plasma for coronavirus disease 2019 infection; none were conducted in the United States nor used standard plasma as a comparator. To determine if administration of convalescent plasma to patients with coronavirus disease 2019 increases antibodies to severe acute respiratory syndrome coronavirus 2 and improves outcome.

DESIGN:
Double-blind randomized controlled trial.

SETTING:
Hospital in New York.

PATIENTS:
Patients with polymerase chain reaction documented coronavirus disease 2019 infection.

INTERVENTIONS:
Patients were randomized (4:1) to receive 2 U of convalescent plasma versus standard plasma. Antibodies to severe acute respiratory syndrome coronavirus 2 were measured in plasma units and in trial recipients.

MEASUREMENTS AND MAIN RESULTS:
Enrollment was terminated after emergency use authorization was granted for convalescent plasma. Seventy-four patients were randomized. At baseline, mean (sd) Acute Physiology and Chronic Health Evaluation II score (23.4 [5.6] and 22.5 [6.6]), percent of patients intubated (19% and 20%), and median (interquartile range) days from symptom onset to randomization of 9 (6–18) and 9 (6–15), were similar in the convalescent plasma versus standard plasma arms, respectively. Convalescent plasma had high neutralizing activity (median [interquartile range] titer 1:526 [1:359–1:786]) and its administration increased antibodies to severe acute respiratory syndrome coronavirus 2 by 14.4%, whereas standard plasma administration led to an 8.6% decrease (p = 0.005). No difference was observed for ventilator-free days through 28 days (primary study endpoint): median (interquartile range) of 28 (2–28) versus 28 (0–28; p = 0.86) for the convalescent plasma and standard plasma groups, respectively. A greater than or equal to 2 point improvement in the World Health Organization scale was achieved by 20% of subjects in both arms (p = 0.99). All-cause mortality through 90 days was numerically lower in the convalescent plasma versus standard plasma groups (27% vs 33%; p = 0.63) but did not achieve statistical significance. A key prespecified subgroup analysis of time to death in patients who were intubated at baseline was statistically significant; however, sample size numbers were small.

CONCLUSIONS:
Administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated with improved outcome.
Anterior chamber depth variability between 2 hydrophobic acrylic 1-piece intraocular lenses: randomized trial
Authors: Ullrich Marlies , Ruiss Manuel , Hienert Julius , Pilwachs Caroline , Fisus Andreea Dana , Georgiev Stefan , Hirnschall Nino , Findl Oliver 
Published: April 2021

Purpose:
To analyze the difference in anterior chamber depth (ACD) after uneventful cataract surgery between 2 hydrophobic acrylic 1-piece intraocular lenses (IOLs) with different material properties.

Setting:
Hanusch Hospital, Vienna, Austria.

Design:
Single-center, bilateral randomized paired-eye controlled study.

Methods:
Patients scheduled for bilateral cataract surgery were randomized to receive the Clareon IOL in 1 eye and the AcrySof IQ IOL (both Alcon Laboratories, Inc.) in the contralateral eye. Preoperatively, a slitlamp examination, optical biometry (IOLMaster 700, Carl Zeiss Meditec AG), refraction, and visual acuity measurements were performed. ACD was assessed 1 hour and 1 week postoperatively and with additional measurement of uncorrected (UDVA) and corrected distance visual acuity (CDVA) 6 months postoperatively.

Results:
80 eyes of 40 patients were analyzed in this study. ACD at the 6-month follow-up was 3.94 ± 0.30 mm for the Clareon IOL and 3.91 ± 0.32 mm for the AcrySof IQ IOL (P = .08). Statistically significant differences in the ACD shift between both IOLs were detected between 1 week and 6 months (P = .04) and 1 hour and 6 months (P = .04). There were no statistically significant differences between both IOLs in UDVA (P = .78), CDVA (P = .59), and spherical equivalent (SE, P = .39) at the 6-month visit. The mean absolute error between the measured and the aimed SE was not significant (P = .97).

Conclusions:
There was no clinically relevant difference in ACD between the Clareon IOL and the AcrySof IQ IOL in patients after uneventful cataract surgery. Both IOLs yielded good refraction and visual acuity outcomes.
Experience of resources management on coronavirus disease 2019 epidemic at a tertiary medical center in Northern Taiwan
Authors: Lan Kai-Ping , Hsu Yueh-Shuang , Chang Ching-I , Wei Pi-Ching , Guo Ti-Gen , Yen David Hung-Tsang , Hsu Teh-Fu , Tzeng Yuann-Meei , Ming Jin-Lain 
Published: April 2021

Background:
Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes infectious symptoms including fever, cough, respiratory and gastrointestinal symptoms, and even loss of smell/taste and to date had caused 489 000 people to be infected with 32 000 deaths. This article aims to develop some strategies in dealing with the COVID-19 epidemic to prevent nosocomial infection and ensure the safety of healthcare workforce and employees.

Methods:
This is a prospectively registered and retrospective descriptive study investigating the clinical characteristics, results of diagnostic tests, and patients’ disposition from February 1, 2020, to April 30, 2020, at a tertiary medical center in Northern Taiwan.

Results:
There is no nosocomial spreading of SARS-CoV-2 in our facility. The following strategies were followed: information transparency; epidemic prevention resources planning by authorities; multidisciplinary cooperation; informative technologies; immigration quarantine policies; travel restrictions; management of diversion/subdivision; self-health monitoring; social distancing; screening of travel, occupation, contact, and cluster (TOCC) history; traffic control bundling (TCB); training of using personal protective equipment; real-name visiting management; and employee care. The patients’ basic characteristics and diagnostic results were gathered. Of the 3832 cases, about 25.9% had travel history. Most of them were traveling to Asia (419 people/time, 10.9%) and from China (256 people/time, 6.7%). Meanwhile, healthcare personnel accounted for 316 people/time (8.3%) and cleaning personnel, 6 people/time (0.16%). The 36 cases who care or have contact with confirmed cases have negative results from the COVID-19 test. The most frequent symptoms were fever and upper respiratory infection followed by gastrointestinal symptoms.

Conclusion:
The above strategies were followed. Patients were stratified based on the risk of TOCC history assessment to ensure the safety of healthcare personnel and patients’ appropriate and timely medical services.
Lipid effects of sodium-glucose cotransporter 2 inhibitors
Authors: Lazarte Julieta , Kanagalingam Tharsan , Hegele Robert A. 
Published: April 2021

Purpose of review
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used antihyperglycemic drugs that show remarkable cardiorenal protective effects in patients with or without type 2 diabetes. Furthermore, they are effective among patients across a wide range of baseline renal and cardiac function. Numerous mechanisms have been evaluated to understand these remarkable clinical benefits. From an early stage, these agents were noted to affect the plasma lipid profile. Here we review lipid profile alterations attributable to SGLT2 inhibitors and also some mechanisms explored in model systems and human studies.

Recent findings
SGLT2 inhibitors given to patients with diabetes as monotherapy shift substrate utilization from carbohydrates to lipids, and have mild effects on the lipid profile. Increased LDL cholesterol appears to be associated with increased hepatic production and decreased catabolism. Increased HDL cholesterol and decreased triglycerides appear to be associated with improved insulin sensitivity and increased lipolysis. Lipid effects of SGLT2 inhibitors are further modulated by background therapy with other diabetes medications and statins.

Summary
The minor lipid profile alterations observed in patients treated with SGLT2 inhibitors are offset by the staggering range of beneficial pleiotropic mechanisms that likely explain the marked cardiorenal benefits of these agents.
The clinical epidemiology of coronavirus disease 2019 in children and adolescents mirrors the widening gap in healthcare disparities
Authors: Zirinsky Elissa , Paintsil Elijah , Oliveira Carlos R. 
Published: April 2021

Purpose of review
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has exacerbated the longstanding racial/ethnic health disparities in the USA, with a disproportionately negative effect on children of color. This review summarizes recently published studies that describe the clinical epidemiology and racial/ethnic disparities associated with SARS-CoV-2 in children.

Recent findings
Children with SARS-CoV-2 infections manifest with a wide spectrum of disease. Most are either asymptomatic or mildly symptomatic with fever, gastrointestinal, and/or upper respiratory disease. Some children can progress to develop severe lower respiratory disease or a hyper-inflammatory, Kawasaki-like syndrome leading to cardiovascular shock. Although SARS-CoV-2-related deaths in children are rare, more children died within the first nine months of the pandemic than have died during any influenza season over the last decade.
Black and Hispanic children represent less than 41% of the US population but account for three out of every four SARS-CoV-2-related hospitalizations and deaths in the USA. The drivers of these disparities in children are complex and likely a combination of societal, biological, and behavioral influences.

Summary
This pandemic brought to light longstanding health disparities in historically marginalized populations, and minority children have suffered tremendously. It provides an opportunity to understand how a virus hijacked deep-rooted inequities, address these inequities, and work to prevent this outcome in future pandemics/epidemics.