bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic analysis of integrated vegetable–poultry production systems in the Babati District of Tanzania
Authors: Habiyaremye Naphtal , Ochieng Justus , Heckelei Thomas 
Published: January 2021

AbstractBackgroundIntegrated vegetable–poultry production system has recently attracted attention both from the scientific and policy making communities for its potential contribution to food security as well as the opportunities it offers in improving the livelihoods of smallholder farmers in Tanzania. Despite the efforts made, its benefits and costs in heterogeneous and real-world settings are not fully understood. Despite the promising design of the vegetable–poultry production system, rather little is known of its profitability and its contribution to better living conditions of rural households in different real-world settings. The same applies regarding the knowledge on factors influencing the decision to adopt such an integrated system.MethodsUsing cross-sectional data collected from 250 households in Babati district of Tanzania, we employ a gross margin analysis and a logit model to evaluate the profitability and to investigate the factors influencing the decision to integrate vegetable and poultry production systems.ResultsWe find that the integrated vegetable–poultry production system is more profitable than vegetable farming alone and the profitability increases as the poultry flock size increases. An integrating household should keep 18 birds to get significant higher profit than non-integrator. Furthermore, gender and education level of the household head, awareness of integration benefits, land owned, household size, off-farm income, and total income received by the household influence the decision to integrate vegetable and poultry.ConclusionThe study strongly promotes the integration of vegetable–poultry production system and highlights the influence of gender and awareness of integration benefits on the decision to integrate vegetable and poultry. Hence, the policy implication is to empower women and provide capacity building through training and extension services such as provision of affordable and improved vegetable seeds and poultry breeds.
Experimental Investigation of the Mechanical Behaviour of Wall–Beam–Strut Joints for Prefabricated Underground Construction
Authors: Liu Tingjin , Lu Jiandong , Wang Di , Liu Hongyuan 
Published: January 2021

AbstractPrefabricated construction is becoming increasingly prevalent, however, it is rarely applied in underground constructions, except for tunnel linings, due to the difficulties that arise in jointing various prefabricated components in underground conditions. To solve the vertical location problem of embedded mechanical couplers during the construction of wall–beam–strut joints for a prefabricated metro station, a new connection using welded steel plates is proposed. In this paper, four full-scale specimens of wall–beam–strut joints connected using welded steel plates and mechanical couplers were experimentally tested under monotonic and low-reversed cyclic loading conditions. The testing results were analysed in terms of the ultimate bearing capacity, failure mode, hysteresis, skeleton curve, stiffness degradation, energy dissipation and strain of the reinforcement bars. Notably, the two kinds of joints had similar ultimate bearing capacities and failure modes, but the crack distributions on the tops of the waler beams were different. For the specimens with the welded steel plate connection, tensile horizontal cracks first appeared on the top surface of the beam, where the welded steel plate was located, and then coalesced gradually; however, this cracking pattern was not observed during the experimental test of the specimens connected with the mechanical couplers. Furthermore, it was determined that the energy dissipation and ductility of the welded steel plate connection were better than those of the mechanical coupler connected joint, because the steel plate could redistribute the internal force in the joint and increase the stiffness. It was concluded that the proposed welded steel plate connection could be more favourable than the mechanical coupler connection in the construction of a prefabricated metro station in Guangzhou. Moreover, the results obtained from these experiments could provide guidelines for the corresponding connections employed in underground-prefabricated structures.
Batch effects account for the main findings of an in utero human intestinal bacterial colonization study
Authors: de Goffau Marcus C. , Charnock-Jones D. Stephen , Smith Gordon C. S. , Parkhill Julian 
Published: January 2021

AbstractA recent study by Rackaityte et al. reported evidence for a low level of bacterial colonization, specifically of Micrococcus luteus, in the intestine of second trimester human fetuses. We have re-analyzed their sequence data and identified a batch effect which violates the underlying assumptions of the bioinformatic method used for contamination removal. This batch effect resulted in Micrococcus not being identified as a contaminant in the original work and being falsely assigned to the fetal samples. We further provide evidence that the micrographs presented by Rackaityte et al. are unlikely to show Micrococci or other bacteria as the size of the particles shown exceeds that of related bacterial cells. Finally, phylogenetic analysis showed that the microbes cultured from the fetal samples differed significantly from those detected by sequencing. Overall, our findings show that the presence of Micrococcus in the fetal gut is not supported by the primary sequence data. Our findings underline important aspects of the nature of contamination for both sequencing and culture approaches in microbiome studies and the appropriate use of automated contamination identification tools.
Fertility education: what’s trending on Instagram
Authors: Peyser Alexandra , Goldstein Liat , Mullin Christine , Goldman Randi H. 
Published: January 2021

Abstract
Objective
To determine the prevalence, authorship, and types of fertility-related information shared on Instagram targeted toward a new patient interested in fertility options using hashtag and content analysis. Secondary outcomes included comparison of post content stratified by author type (physicians versus patients).

Methods
A list of ten hashtags consisting of fertility terms for the new patient was derived. Content analysis was performed in April 2019 on the top 50 and most recent 50 posts for each hashtag to determine authorship and content type. The distribution of fertility terms in posts made by physicians was compared to that of patients and differences in use of terms were analyzed.

Results
Our search yielded 3,393,636 posts. The two most popular hashtags were IVF (N = 912,049), and Infertility (N = 852,939). Authorship of the top posts for each hashtag (N = 1000) were as follows: patients (67 %), physicians (10 %), for-profit commercial groups (6.0 %), allied health professional (4.5 %), professional societies (1 %), and other (11 %). Of these posts, 60 % related to patient experiences, 10 % advertisements, 10 % outreach, and 8 % educational. Physicians were more likely to author posts related to oocyte cryopreservation compared to IVF, while patients were more likely to author posts about IVF (p < 0.0001).

Conclusions
Over 3 million posts related to fertility were authored on Instagram. A majority of fertility posts are being mobilized by patients to publicly display and share their personal experiences. Concurrent with the rising utilization of planned oocyte cryopreservation, there is a trend toward physicians educating their patients about the process using social media as a platform. Physician participation on social media may offer a low-cost platform for networking and connecting with patients. Future studies examining the educational quality of posts by author type should be explored.
Single-incision laparoscopic antrectomy for type I gastric neuroendocrine tumor: a case report
Authors: Kitadani Junya , Ojima Toshiyasu , Hayata Keiji , Katsuda Masahiro , Tominaga Shinta , Fukuda Naoki , Motobayashi Hideki , Nagano Shotaro , Nakamura Masaki , Yamaue Hiroki 
Published: January 2021

Abstract
Background
Type I gastric neuroendocrine tumors (GNETs) originate from hyperplasia of enterochromaffin­like (ECL) cells and are commonly detected in patients with chronic atrophic gastritis, including autoimmune gastritis. Typical treatment for type I GNETs comprises simple surveillance and/or endoscopic resection. For alleviation of hypergastrinemia resulting in ECL cell hypertrophy, antrectomy is a treatment option. Type I GNETs mostly have excellent prognosis, and if a surgical approach is chosen, the procedure must be minimally invasive. One such technique for multiple type I GNETs, minimally invasive single-incision laparoscopic antrectomy (SILA), is reported here for the first time.

Case presentation
We performed SILA on a 46-year-old woman who developed type I GNETs caused by hypergastrinemia due to autoimmune gastritis. A Lap-Protector was inserted in a 3 cm incision at the umbilicus, and set an EZ Access equipped with two 5 mm trocars and one 12 mm trocar. Antrectomy without lymph node dissection was performed using a 5 mm forward-oblique viewing endoscope, a vessel sealing device, and linear staplers, while reconstruction was by Billroth I reconstruction. Side-to-side anastomosis was performed using a 45 mm linear stapler. The stapler entry hole was sutured intracorporeally using barbed suture material. The operation time was 140 min and blood loss was 5 ml. The patient was discharged ten days after surgery without complications. Serum gastrin level decreased to within the normal range on the day after the operation. One year after surgery, esophagogastroduodenoscopy showed pathological disappearance of all lesions of the remnant stomach.

Conclusions
SILA is a minimally-invasive and tolerable technique for treatment of multiple type I GNETs. In this reported case there was good cohesiveness and effectiveness in normalizing gastrin levels and in elimination of remnant gastric lesions.
Does curve magnitude in adolescent idiopathic scoliosis (AIS) affect frequency and quality of sport participation? A feasibility study
Authors: Youssef Michael , Soliman John , Burrow Sarah , Kishta Waleed , Simunovic Nicole , Duong Andrew , Ayeni Olufemi R. , Peterson Devin 
Published: January 2021

AbstractBackgroundThis pilot study explores whether large adolescent idiopathic scoliosis (AIS) curves (≥ 45°) lead to decreased frequency and quality of sport participation, lower health-related quality of life (HRQL), and more pronounced shortness of breath (SOB) as compared to smaller curvatures (< 45°).MethodsPatients were divided into two groups based on their spinal curvature: Cobb angle < 45° (n= 31) and ≥ 45° (n= 21). We assessed feasibility outcomes including agreement to be approached, participation, recruitment rates and missing data. All participants completed five questionnaires to assess the frequency and quality of sport participation, HRQL and SOB outcomes. Estimates of effects 95% confidence intervals (CIs) were reported.ResultsThis study enrolled 52 surgically untreated AIS patients between the ages of 10 and 18 (44 females, 8 males, mean age = 14.60). All feasibility threshold criteria were successfully met (100% agreement to be approached, 100% participation withn≥ 12 in each group, and 94.2% of patients without missing data). AIS patients with large curvatures (≥ 45°) trended towards decreased frequency and quality of sport participation, more pronounced SOB and worse HRQL outcomes, as compared to patients with smaller curve sizes.ConclusionThe study findings show that a study addressing sport participation in the setting of AIS is feasible. The size of curvature in AIS may have an impact on sport participation, HRQL and SOB, but larger studies are required.
The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis
Authors: Salari Nader , Mansouri Kamran , Hosseinian-Far Amin , Ghasemi Hooman , Mohammadi Masoud , Jalali Rostam , Vaisi-Raygani Aliakbar 
Published: January 2021

Abstract
Background
Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary artery disease, Due to the short half-life and high variability of Interleukin-6 (IL-6), limited studies have been performed on the association of serum levels of interleukin-6 with coronary artery disease. The aim of this study is to investigate the relationship between IL-6 gene polymorphisms and coronary artery disease.

Methods
This study was conducted as a meta-analysis of selected articles with no lower time limit and upto March 2020. Articles related to the subject were obtained by searching several data sources,such as the SID, IranDoc, Scopus, Embase, Web of Science (ISI), PubMed, Science Direct, and Google Scholar databases. The heterogeneity of the studies was assessed using the I2 index in the Comprehensive Meta-Analysis software.

Results
The GG genotype of the IL-6174 G> C polymorphism with a 0.8 odds ratio tended to reduce the risk of CAD by 20%. The odds ratio of CAD in CG and GG genotypes were found to be 1.16 and 1.48 times respectively, indicating the increasing effect of these two genotypes. In the IL-6-572 C>G polymorphism, CG and GG genotypes increased the risk of CAD by 1.21 and 1.27 times respectively, and the CC genotype tended to reduce the risk of CAD by 15%, considering the odds ratio of 0.85.

Conclusion
This study showed a relationship between IL-6174G> C and Interleukin-6 (IL-6) 572 C>G genes and coronary artery disease. Moreover, the protective effects of GG genotype in IL-6 gene 174 G> C and CC genotype in IL-6 gene 572 C>G gene were reported. The study also confirmed that the CG and CC genotypes of the G>C IL-6174 gene have an increasing effect on coronary artery disease. Moreover, CG and GG genotypes in the IL-6 gene 572 C>G increased the risk of developing CAD. It should be noted that the increased risk of developing CAD was limited to meta-analytic studies in reported literatures.
Implementing the transvaginal ultrasound simulation training (TRUSST) programme for obstetric registrars
Authors: Byford Sally , Janssens Sarah , Cook Rachel 
Published: January 2021

Abstract
Background
Transvaginal ultrasound (TVUS) training opportunities are limited due to its intimate nature; however, TVUS is an important component of early pregnancy assessment. Simulation can bridge this learning gap.

Aim
To describe and measure the effect of a transvaginal ultrasound simulation programme for obstetric registrars.

Materials and methods
The transvaginal ultrasound simulation training (TRUSST) curriculum consisted of supported practice using virtual reality transvaginal simulators (ScanTrainer, Medaphor) and communication skills training to assist obstetric registrars in obtaining required competencies to accurately and holistically care for women with early pregnancy complications.
Trainee experience of live transvaginal scanning was evaluated with a questionnaire. Programme evaluation was by pre-post self-reported confidence level and objective pre-post training assessment using Objective Structured Assessment of Ultrasound Skills (OSAUS) and modified Royal Australian and New Zealand College of Obstetrics and Gynaecology assessment scores. Quantitative data was compared using paired t tests.

Results
Fifteen obstetric registrars completed the programme. Numbers of performed live transvaginal ultrasound by trainees were low. Participants reported an increase in confidence level in performing a TVUS following training: mean pre score 1.6/5, mean post score 3/5. Objective assessments improved significantly across both OSAUS and RANZCOG scores following training; mean improvement scores 7.6 points (95% CI 6.2–8.9, p < 0.05) and 32.5 (95% CI 26.4–38.6, p < 0.05) respectively. It was noted that scores for a systematic approach and documentation were most improved: 1.9 (95% CI 1.4–2.5, p < 0.05) and 2.1 (95% CI 1.5–2.7, p < 0.05) respectively.

Conclusion
The implementation of a simulation-based training curriculum resulted in improved confidence and ability in TVUS scanning, especially with regard to a systematic approach and documentation.
Acceptability of the e-authentication in higher education studies: views of students with special educational needs and disabilities
Authors: Laamanen Merja , Ladonlahti Tarja , Uotinen Sanna , Okada Alexandra , Bañeres David , Koçdar Serpil 
Published: January 2021

AbstractTrust-based e-assessment systems are increasingly important in the digital age for both academic institutions and students, including students with special educational needs and disabilities (SEND). Recent literature indicates a growing number of studies about e-authentication and authorship verification for quality assurance with more flexible modes of assessment. Yet understanding the acceptability of e-authentication systems among SEND students is underexplored. This study examines SEND students’ views about the use of e-authentication systems, including perceived advantages and disadvantages of new technology-enhanced assessment. This study aims to shed light on this area by examining the attitudes of 267 SEND students who used, or were aware of, an authentication system known as adaptive trust-based e-assessment system for learning (TeSLA). The results suggest a broadly positive acceptability of these e-authentication technologies by SEND students. In the view of these students, the key advantages are the ability of proving the originality of their work, and trust-based e-assessment results; the key disadvantages are the possibility that the technology might not work or present wrong outputs in terms of cheating.
Rising trends towards the development of oral herbal male contraceptive: an insight review
Authors: Verma Surender , Yadav Akash 
Published: January 2021

AbstractBackgroundAcknowledging population control to be an essential step for global health promotes wide research study in the area of male contraception. Although there are a great number of synthetic contraceptives available in the market, they have plenty of adverse effects. Different potential strategies for male contraception were investigated over a long period time consisting of hormonal, chemical, and immunological interventions, although these methods showed good antifertility results with low failure rates relative to condoms.Main textThis review is based upon the concept of herbal contraceptives which are an effective method for controlling the fertility of animals and humans. This review has highlighted herbal medicinal plants and plant extracts which have been reported to possess significant antifertility action in males. The review considers those plants which are used traditionally for their spermicidal and antispermatogenic activities and imbalance essential hormones for fertility purposes and plants with reported animal studies as well as some with human studies for antifertility effect along with their doses, chemical constituents, and mechanism of action of the antifertility effect of the plants. This review also explains the phases of sperm formation, hormone production, and the mechanism of male contraceptives.ConclusionAs far as the relevance of the current review is discussed, it might be quite useful in generating monographs on plants and recommendations on their use. A lot of the plant species listed here might appear promising as effective alternative oral fertility-regulating agents in males. Therefore, significant research into the chemical and biological properties of such less-explored plants is still needed to determine their contraceptive efficacy and also to possibly define their toxic effects so that these ingredients can be utilized with confidence to regulate male fertility. The new inventions in this field are necessary to concentrate on modern, more potent drugs with less harmful content and that are self-administrable, less costly, and entirely reversible.
Real-World Costs of Azacitidine Treatment in Patients With Higher-Risk Myelodysplastic Syndromes/Low Blast–Count Acute Myeloid Leukemia
Authors: Mozessohn Lee , Cheung Matthew C. , Mittmann Nicole , Earle Craig C. , Liu Ning , Buckstein Rena 
Published: January 2021

PURPOSE: Azacitidine (AZA) is a standard of care for higher-risk myelodysplastic syndrome (MDS)/low blast–count acute myeloid leukemia (AML). Despite this, there is a paucity of data on the real-world health care resource utilization costs of AZA in this population. METHODS: We linked the Ontario AZA MDS registry—higher-risk MDS/low blast–count AML—to population-based health system administrative databases. Patients were observed for 24 months after first AZA and censored at the earliest of 90 days after last AZA, date of death, time of AML induction/stem-cell transplantation, or March 31, 2016. Costs (2015 Canadian dollars) were expressed as standardized mean and median 28-day costs. Univariable quantile regression was used to explore the association of baseline patient and disease characteristics and median cost. Multivariable quantile regression was used to explore predictors of median costs. RESULTS: Among 877 patients in the registry, mean standardized 28-day cost per patient was $17,638 (median, $15,272; interquartile range [IQR], $11,869-$19,580) and $13,450 (median, $11,043; IQR, $7,981-$14,882) excluding the cost of AZA. Major nondrug drivers of cost were cancer clinic visits and inpatient care (mean standardized 28-day cost, $4,631; median, $1,558; IQR, $238-$4,961). Transfusion dependence at AZA initiation ( P = .001) and greater comorbid disease burden ( P = .009) were independently associated with increased cost. CONCLUSION: Our cohort of patients with uniformly higher-risk MDS/low blast–count AML treated with AZA demonstrates substantial costs of care above and beyond the cost of AZA alone. These results provide insight into the costs of AZA in the real world with implications for resource allocation.
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Authors: Ulmke Pauline Antonie , Xie Yuanbin , Sokpor Godwin , Pham Linh , Shomroni Orr , Berulava Tea , Rosenbusch Joachim , Basu Uttiya , Fischer Andre , Nguyen Huu Phuc , Staiger Jochen F. , Tuoc Tran 
Published: January 2021

ABSTRACT
Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels, including RNA decay. N6-methyladenosine (m6A) methylation-mediated degradation of RNA is essential for brain development. However, m6A methylation impacts not only RNA stability, but also other RNA metabolism processes. How RNA decay contributes to brain development is largely unknown. Here, we show that Exosc10, a RNA exonuclease subunit of the RNA exosome complex, is indispensable for forebrain development. We report that cortical cells undergo overt apoptosis, culminating in cortical agenesis upon conditional deletion of Exosc10 in mouse cortex. Mechanistically, Exosc10 directly binds and degrades transcripts of the P53 signaling-related genes, such as Aen and Bbc3. Overall, our findings suggest a crucial role for Exosc10 in suppressing the P53 pathway, in which the rapid turnover of the apoptosis effectors Aen and Bbc3 mRNAs is essential for cell survival and normal cortical histogenesis.