bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells
Authors: Nema Rajeev , Kumar Ashok 
Published: June 2021

Background: Triple-negative breast cancer (TNBC) is associated with a poor prognosis. Sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes that are important for breast cancer (BC). S1P signaling regulates tumorigenesis, and response to chemotherapy and immunotherapy by affecting the trafficking, differentiation or effector function of tumor-infiltrating immune cells (TIICs).Objective: In this study, using bioinformatics tools and publicly available databases, we have analyzed the prognostic value of S1P metabolizing genes and their correlation with TIICs in BC patients.Methods: The expression of S1P metabolizing genes and receptors was evaluated by the UALCAN cancer database. The correlation between mRNA expression of S1P metabolizing genes and receptors and survival outcome of breast cancer patients was analyzed by the Kaplan-Meier plotter database. The association between the gene expression and infiltration of immune cells in the tumors was analyzed by “Tumor-Infiltrating Immune Estimation Resource (TIMER). In silico protein expression analysis was done using the Human Protein Atlas” database.Results: TNBC patients with lower expression of S1P phosphatase 1 (SGPP1) or lipid phosphate phosphatase 3 (PLPP3) have much shorter relapse-free survival than the patients with a higher expression of these genes. SGPP1 and PLPP3 expression show a strong positive correlation with tumor-infiltrating dendritic cells (DCs), CD4+ and CD8+ T cells, neutrophils, and macrophages in the TNBC subtypes. In addition, S1P receptor 4 (S1PR4), an S1P receptor exhibit a strong positive correlation with DCs, CD4+ and CD8+ T cells and neutrophils in TNBC. We, therefore, conclude that low expression of SGPP1 and PLPP3 may hinder the recruitment of immune cells to the tumor environment, resulting in the blockage of cancer cell clearance and a subsequent poor prognosis.
Ki67 Index Changes and Tumor-Infiltrating Lymphocyte Levels Impact the Prognosis of Triple-Negative Breast Cancer Patients With Residual Disease After Neoadjuvant Chemotherapy
Authors: Wang Yihua , Zong Beige , Yu Yu , Wang Yu , Tang Zhenrong , Chen Rui , Huang Man , Liu Shengchun 
Published: June 2021

PurposeThe aim of this study was to assess the prognostic influence of Ki67 index changes in patients with primary triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC), and to evaluate whether the combination of Ki67 index changes and residual disease (RD) tumor-infiltrating lymphocytes (TILs) provides additional prognostic information for this group.Materials and MethodsData from 109 patients with primary TNBC and RD after NAC were analyzed retrospectively. Ki67 changes and RD TIL levels were investigated for associations with recurrence-free survival (RFS) and overall survival (OS) using Kaplan–Meier and Cox analyses.ResultsKi67 index decreased after NAC in 53 patients (48.6%) and high RD TIL levels (≥30%) were observed in 54 patients (49.5%). In multivariate Cox analyses, no Ki67 decrease status and low RD TIL levels were significantly associated with reduced RFS (hazard ratio (HR): 2.038, 95% confidence interval (CI): 1.135–3.658, P = 0.017; HR: 2.493, 95% CI: 1.335–4.653, P = 0.004), and OS (HR: 2.187, 95% CI: 1.173–4.077, P = 0.014; HR: 2.499, 95% CI: 1.285–4.858, P = 0.007), respectively. Notably, low RD TIL levels were significantly associated with reduced RFS (HR: 3.567, 95% CI: 1.475–8.624, P = 0.005) and reduced OS (HR: 3.873, 95% CI: 1.512–9.918, P = 0.005) in only the no Ki67 decrease group. The differences in 3-year RFS and OS between patients with no Ki67 decrease and low or high RD TIL levels were 24.4% vs 79.1% (P = 0.0001) and 33.1% vs 87.5% (P = 0.0001), respectively.ConclusionKi67 index changes and RD TIL levels were associated with the prognosis of patients with primary TNBC with RD after NAC. RD TIL levels had greater prognostic significance in the no Ki67 decrease group.
Extrauterine Growth Restriction in Very Low Birth Weight Infants: Concordance Between Fenton 2013 and INTERGROWTH-21st Growth Charts
Authors: González-García Lara , García-López Enrique , Fernández-Colomer Belén , Mantecón-Fernández Laura , Lareu-Vidal Sonia , Suárez-Rodríguez Marta , Arias-Llorente Rosa Patricia , Solís-Sánchez Gonzalo 
Published: June 2021

Postnatal growth restriction has high prevalence in very low birth weight (VLBW) preterm neonates, and this could affect their long-term prognosis. Nowadays, there is no consensus on how to monitor growth in these neonates.Objective:This study aimed to compare prevalence of intra- and extrauterine growth restriction (IUGR and EUGR) in a sample of VLBW infants according to the Fenton 2013 charts and INTERGROWTH-21st (IW-21) standards and to analyze concordance between both in the different EUGR definitions criteria (cross-sectional, dynamic, and true).Patients and Methods:An observational retrospective study of 635 VLBW preterm was performed. The study was carried out in Central University Hospital of Asturias. Body measurements (weight, length, and head circumference) were collected at birth and at hospital discharge and expressed in z-scores for the two references (Fenton 2010 and IW-21). Kappa concordance was calculated.Results:Kappa concordance between Fenton and IW-21 was 0.887 for IUGR and 0.580 for static EUGR. Prevalence was higher according to Fenton in IUGR (36.5 vs. 35.1%), in static EUGR (73.8 vs. 59.3%), and in dynamic EUGR (44.3 vs. 29.3%). Despite observing low prevalence of EUGR when IW-21 was used to define EUGR, a statistical association between neonatal morbidity and diagnosis of EUGR was observed.Conclusion:The Fenton and IW-21 concordance for IUGR is good. IW-21 is more restrictive than Fenton in EUGR. Patients diagnosed by IW-21 as EUGR are more likely to have neonatal morbidity, especially if we use EUGR dynamic definition. In our study, we cannot conclude that one graph is better than the other.
Participant Experiences of Transcranial Direct Current Stimulation (tDCS) as a Treatment for Antipsychotic Medication Induced Weight Gain
Authors: Grycuk Luiza , Moruzzi Francesca , Bardjesteh Elena , Gaughran Fiona , Campbell Iain C. , Schmidt Ulrike 
Published: June 2021

Background: Despite the growing number of studies on the use of non-invasive brain stimulation in people with schizophrenia, there is limited research on participant views of such treatment methods.Aim: Explore participant experiences and perceptions of transcranial direct current stimulation (tDCS).Methods: Twelve people with schizophrenia took part in semi-structured interviews after having completed 5 sessions of tDCS. Thematic analysis was used to identify codes and themes.Results: Five themes were identified: (1) motivation for study enrolment; (2) concerns about tDCS; (3) factors reducing the fear of tDCS; (4) experience of tDCS; (5) perceived effects of tDCS.Conclusions: The study provides insight into the perceptions and experiences of each individual. Participants were concerned about the safety of tDCS and associated it with invasive procedures such as electroconvulsive therapy and lobotomy. Educational materials and a good relationship with the researcher played an important role in reducing the fear of brain stimulation. All participants described tDCS as uncomfortable, however, agreed that unpleasant sensations only lasted for a short while (20 s−5 min). After the first session, participants no longer felt anxious about the remaining ones. Strategies to improve treatment experience and study recruitment have been identified.
Pills, PrEP, and Pals: Adherence, Stigma, Resilience, Faith and the Need to Connect Among Minority Women With HIV/AIDS in a US HIV Epicenter
Authors: Duthely Lunthita M. , Sanchez-Covarrubias Alex P. , Brown Megan R. , Thomas Tanya E. , Montgomerie Emily K. , Dale Sannisha , Safren Steven A. , Potter JoNell E. 
Published: June 2021

Background: Ending HIV/AIDS in the United States requires tailored interventions. This study is part of a larger investigation to design mCARES, a mobile technology-based, adherence intervention for ethnic minority women with HIV (MWH).Objective: To understand barriers and facilitators of care adherence (treatment and appointment) for ethnic MWH; examine the relationship between these factors across three ethnic groups; and, explore the role of mobile technologies in care adherence.Methods: Cross-sectional, mixed-methods data were collected from a cohort of African-American, Hispanic-American and Haitian-American participants. Qualitative data were collected through a focus group (n = 8) to assess barriers and facilitators to care adherence. Quantitative data (n = 48) surveyed women on depressive symptomology (PHQ-9), HIV-related stigma (HSS) and resiliency (CD-RISC25). We examined the relationships between these factors and adherence to treatment and care and across groups.Findings: Qualitative analyses revealed that barriers to treatment and appointment adherence were caregiver-related stressors (25%) and structural issues (25%); routinization (30%) and religion/spirituality (30%) promoted adherence to treatment and care. Caregiver role was both a hindrance (25%) and promoter (20%) of adherence to treatment and appointments. Quantitatively, HIV-related stigma differed by ethnic group; Haitian-Americans endorsed the highest levels while African-Americans endorsed the lowest. Depression correlated to stigma (R = 0.534; p &lt; 0.001) and resiliency (R = −0.486; p &lt; 0.001). Across ethnic groups, higher depressive symptomology and stigma were related to viral non-suppression (p &lt; 0.05)—a treatment adherence marker; higher resiliency was related to viral suppression. Among Hispanic-Americans, viral non-suppression was related to depression (p &lt; 0.05), and among African-Americans, viral suppression was related to increased resiliency (p &lt; 0.04).Conclusion: Multiple interrelated barriers to adherence were identified. These findings on ethnic group-specific differences underscore the importance of implementing culturally-competent interventions. While privacy and confidentiality were of concern, participants suggested additional intervention features and endorsed the use of mCARES as a strategy to improve adherence to treatment and appointments.
Logically Inferred Tuberculosis Transmission (LITT): A Data Integration Algorithm to Rank Potential Source Cases
Authors: Winglee Kathryn , McDaniel Clinton J. , Linde Lauren , Kammerer Steve , Cilnis Martin , Raz Kala M. , Noboa Wendy , Knorr Jillian , Cowan Lauren , Reynolds Sue , Posey James , Sullivan Meissner Jeanne , Poonja Shameer , Shaw Tambi , Talarico Sarah , Silk Benjamin J. 
Published: June 2021

Understanding tuberculosis (TB) transmission chains can help public health staff target their resources to prevent further transmission, but currently there are few tools to automate this process. We have developed the Logically Inferred Tuberculosis Transmission (LITT) algorithm to systematize the integration and analysis of whole-genome sequencing, clinical, and epidemiological data. Based on the work typically performed by hand during a cluster investigation, LITT identifies and ranks potential source cases for each case in a TB cluster. We evaluated LITT using a diverse dataset of 534 cases in 56 clusters (size range: 2–69 cases), which were investigated locally in three different U.S. jurisdictions. Investigators and LITT agreed on the most likely source case for 145 (80%) of 181 cases. By reviewing discrepancies, we found that many of the remaining differences resulted from errors in the dataset used for the LITT algorithm. In addition, we developed a graphical user interface, user's manual, and training resources to improve LITT accessibility for frontline staff. While LITT cannot replace thorough field investigation, the algorithm can help investigators systematically analyze and interpret complex data over the course of a TB cluster investigation.Code available at:https://github.com/CDCgov/TB_molecular_epidemiology/tree/1.0; https://zenodo.org/badge/latestdoi/166261171.
Two Lysine Sites That Can Be Malonylated Are Important for LuxS Regulatory Roles in Bacillus velezensis
Authors: Cao Xianming , Li Yulong , Fan Jialu , Zhao Yinjuan , Borriss Rainer , Fan Ben 
Published: June 2021

S-ribosylhomocysteine lyase (LuxS) has been shown to regulate bacterial multicellular behaviors, typically biofilm formation. However, the mechanisms for the regulation are still mysterious. We previously identified a malonylation modification on K124 and K130 of the LuxS in the plant growth-promoting rhizobacterium B. velezensis (FZB42). In this work, we investigated the effects of the two malonylation sites on biofilm formation and other biological characteristics of FZB42. The results showed that the K124R mutation could severely impair biofilm formation, swarming, and sporulation but promote AI-2 production, suggesting inhibitory effects of high-level AI-2 on the features. All mutations (K124R, K124E, K130R, and K130E) suppressed FZB42 sporulation but increased its antibiotic production. The double mutations generally had a synergistic effect or at least equal to the effects of the single mutations. The mutation of K130 but not of K124 decreased the in vitro enzymatic activity of LuxS, corresponding to the conservation of K130 among various Bacillus LuxS proteins. From the results, we deduce that an alternative regulatory circuit may exist to compensate for the roles of LuxS upon its disruption. This study broadens the understanding of the biological function of LuxS in bacilli and underlines the importance of the two post-translational modification sites.
DETERMINATION OF THE DEVELOPMENT ROLL BY ELECTRONIC MEANS OF GEODESIC MEASUREMENTS
Authors: Гайрабеков И.Г. , Пимшин И.Ю. , Мишиева А.Т. , Шамсудинова К.C. 
Published: June 2021

В статье изложены методика и результаты геодезических работ, выполненных с использованием современных электронных средств измерений для выявления сверхнормативных кренов 30 и 32метровых металлических дымовых труб. Определялись величины кренов по отдельным осям и абсолютная величина крена. Камеральная обработка результатов геодезических измерений была выполнена в программе CredoDat. Анализ и оформление геометрических параметров объектов выполнены в программном продукте ZWCAD. С точек планового обоснования была выполнена съемка характерных строительных элементов трубы. Контроль геометрических параметров сооружения выполнен координатным методом. Установлено, что полный крен 30метрового металлического сооружения после исправления не превышает предельно допустимую величину. Сделан вывод о пригодности сооружения к дальнейшей эксплуатации. Установлено, что полный крен 32метрового металлического сооружения превышает предельно допустимую величину. Сделан вывод о необходимости проведения повторных геодезических измерений с целью выявления динамики развития кренов. Результаты измерений могут быть использованы для выполнения мероприятий по восстановлению эксплуатационной надежности наблюдаемого объекта.
The article describes the methodology and results of geodetic works performed using modern electronic measuring instruments to identify excess rolls 30 meter metal chimney. The values of rolls on separate axes and the absolute value of the roll were determined. Desk processing of the results of geodetic measurements was performed in the program CredoDat. Analysis and design of geometric parameters of objects is made in the software product ZWCAD. From the points of the planned justification, the characteristic construction elements of the pipe were surveyed. Control of the geometric parameters of the structure is performed by the coordinate method. It is established that the total roll of 30 meter metal structure after correction does not exceed the maximum permissible value. It is concluded that the facility is suitable for further operation. It is established that the total roll of the 32meter metal structure exceeds the maximum permissible value. It is concluded that the need for repeated geodetic measurements in order to identify the dynamics of the rolls. The results of measurements can be used to carry out measures to restore the operational reliability of the observed object.
STUDENT PORTFOLIO AS A MEANS OF CAREER PROMOTION
Authors: Магамадова Т.С. , Намаева М.М. 
Published: June 2021

Данная статья посвящена проблеме формирования профессиональной компетентности будущих специалистов с использованием метода профессионального портфолио. Рассмотрены его педагогические возможности и опыт внедрения этой технологии в образовательную деятельность педагогического вуза. В статье приводится описание различных подходов к определению понятия портфолио , рекомендуется создание и использование портфолио в ходе профессиональной подготовки будущих специалистов. Исследования связаны с разработкой конкретной технологии формирования мобильности выпускника в процессе его профессионального становления и развития. Публикация подтверждает, что профессиональное образование будущих специалистов включает в себя необходимость формирования у студентов профессиональнокоммуникативной компетентности, личностных характеристик, системную подготовку к эффективной профессиональной самопрезентации.
This article is devoted to the problem of the formation of professional competence of future social educators using the professional portfolio method. His pedagogical possibilities and experience of introducing this technology into the educational activities of a pedagogical university are examined. The article describes various approaches to the definition of the concept of portfolio, it is recommended that the creation and use of the portfolio in the training of future social educators. Research is associated with the development of a specific technology for the formation of the mobility of a graduate in the process of his professional formation and development. The publication confirms that the professional education of future social educators includes the need for students to develop professional and communicative competence, personal characteristics, and systematic preparation for effective professional selfpresentation.
POSSIBILITY OF USING VOLCANIC ROCKS IN THE CEMENT INDUSTRY
Authors: Байтиев В.А. , Бисултанов Р.Г. , Саламанова М.Ш. , Муртазаев С-А. Ю. 
Published: June 2021

В данной статье раскрываются особенности формирования структуры цементных композиций с применением активной минеральной добавки вулканического происхождения. Полученные ре цептуры композиционных цементов позволят получать высококачественные бетоны с классом прочности от В60 до В100, снижать нормальную густоту бетонных смесей на 2530, при этом подвижность смеси остается постоянной. Кроме того, применение данной разработки позволит повышать темпы набора прочностных показателей бетона, что дает вероятность отказа от тепло вой обработки и способствует получению необходимой для распалубки прочности за промежуток времени 1824 часов. Работа выполнена в рамках исследований по реализации научного проекта 1848-200001 Высококачественные бетоны с повышенными эксплуатационными свойствами на основе местного природного и техногенного сырья , получившего поддержку Российского фонда фундаментальных исследований (РФФИ).
The article reveals the features of the formation of the structure of cement compositions using active mineral additives of volcanic origin. The resulting composition of composite cements will make it possible to obtain high-quality concrete with a strength class from B60 to B100, reduce the normal density of concrete mixtures by 2530, while the mobility of the mixture remains constant. In addition, the use of this development will allow increasing the pace of a set of strength indicators of concrete, which gives the probability of refusal from heat treatment and helps to obtain the strength necessary for stripping for a period of 1824 hours.
PENGATURAN HUKUM MENGENAI DOKUMEN PERJALANAN MENURUT UNDANG-UNDANG NOMOR 6 TAHUN 2011 TENTANG KEIMIGRASIAN
Authors: Laluraa Sinji 
Published: June 2021

Penelitian ini dilakukan dengan tujuan untuk mengetahui bagaimana pengaturan hukum mengenai dokumen perjalanan Republik Indonesia dan bagaimana pemberlakuan ketentuan pidana pada orang akibat tidak menggunakaan atau memalsukan dokumen perjalanan Republik Indonesia. Dengan menggunakan metode penelitian yuridis normative, disimpulkan: 1. Pengaturan hukum mengenai dokumen perjalanan Republik Indonesia sesuai Undang-Undang Nomor 6 Tahun 2011 tentang Keimigrasian, meliputi dokumen perjalanan Republik Indonesia terdiri atas paspor dan surat perjalanan laksana paspor. Paspor terdiri atas paspor diplomatik, paspor dinas dan paspor biasa. Surat perjalanan laksana paspor terdiri atas surat perjalanan laksana paspor untuk warga negara Indonesia dan untuk orang asing serta surat perjalanan lintas batas atau pas lintas batas. Dokumen Perjalanan Republik Indonesia merupakan dokumen Negara yang setiap saat dapat ditarik kembali apabila diperlukan untuk kepentingan negara. Dokumen itu bukanlah surat berharga sehingga dokumen perjalanan Republik Indonesia tidak dapat digunakan untuk hal yang bersifat perdata, antara lain dijadikan jaminan utang. 2. Pemberlakuan ketentuan pidana akibat tidak menggunakan atau memalsukan dokumen perjalanan Republik Indonesia, diantaranya setiap orang asing yang masuk dan/atau berada di wilayah Indonesia yang tidak memiliki dokumen perjalanan dan visa yang sah dan masih berlaku atau menggunakan dokumen perjalanan Republik Indonesia untuk masuk atau keluar wilayah Indonesia, tetapi diketahui atau patut diduga bahwa dokumen perjalanan Republik Indonesia itu palsu atau dipalsukan dipidana dengan pidana penjara paling lama 5 (lima) tahun dan pidana denda paling banyak Rp500.000.000,00 (lima ratus juta rupiah).Kata kunci: Pengaturan Hukum, Dokumen Perjalanan, Keimigrasian
Structuri sociale și identități etnice în epoca metalelor în sud-estul Europei
Authors: Lazăr Simona 
Published: June 2021

In the last decades there had been proposed several theoretical models for different types of exchanges, from those that took place among the neighboring communities to the long distances ones, through the help of the intermediaries. The mechanisms of the goods circulation, essentially different from what we understand today through this process, were based on the principles of reciprocity and redistribution. In order to understand them, and also other aspects related to the complex system of the social and power relations, an important role had the ethno-anthropological studies that offered different interpretation models. It was debated a lot in the Anglo-Saxon literature and not only, on the fact that the contemporary archaeologist judges, inevitably, the objects and the concrete situations from the digs, according to some criteria completely different from the studied cultural context, because he belongs to another “world”, with other psych-socio-cultural features than the people from the near past, this socio-social distance that comes between the archaeologist and the artifact, along with the temporal one, determining the opacity of the last one.
The archaeological data mustn’t permanently inter-relate with the theories. It isn’t always sure that these “stylistic” or “aesthetic” criteria that we consider to be significant were considered the same by the potter from the past. The “style” changes had been many times forcedly associated with the replacement of an archaeological culture with another or changes in the ethnic structure of a community. The changes that appeared in certain types of artifacts can be explained only through economic or symbolic mutations, not necessarily through cultural influences understood linearly (as the representation of some chronological relations between the human groups or through the ethnic relation).