bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition of large R-charge operators on a conformal manifold
Authors: Sharon Adar , Watanabe Masataka 
Published: January 2021

Abstract
We study the transition between phases at large R-charge on a conformal manifold. These phases are characterized by the behaviour of the lowest operator dimension ∆(QR) for fixed and large R-charge QR. We focus, as an example, on the D = 3, $$ \mathcal{N} $$
N
= 2 Wess-Zumino model with cubic superpotential $$ W= XYZ+\frac{\tau }{6}\left({X}^3+{Y}^3+{Z}^3\right) $$
W
=
XYZ
+

τ
6

X
3

+

Y
3

+

Z
3

, and compute ∆(QR, τ) using the ϵ-expansion in three interesting limits. In two of these limits the (leading order) result turns out to be$$ \Delta \left({Q}_{R,\tau}\right)=\left\{\begin{array}{ll}\left(\mathrm{BPS}\;\mathrm{bound}\right)\left[1+O\left(\epsilon {\left|\tau \right|}^2{Q}_R\right)\right],& {Q}_R\ll \left\{\frac{1}{\epsilon },\kern0.5em \frac{1}{\epsilon {\left|\tau \right|}^2}\right\}\\ {}\frac{9}{8}{\left(\frac{\epsilon {\left|\tau \right|}^2}{2+{\left|\tau \right|}^2}\right)}^{\frac{1}{D-1}}{Q}_R^{\frac{D}{D-1}}\left[1+O\left({\left(\epsilon {\left|\tau \right|}^2{Q}_R\right)}^{-\frac{2}{D-1}}\right)\right],& {Q}_R\gg \left\{\begin{array}{ll}\frac{1}{\epsilon },& \frac{1}{\epsilon {\left|\tau \right|}^2}\end{array}\right\}\end{array}\right. $$
Δ

Q

R
,
τ

=

BPS

bound

1
+
O

ϵ

τ

2

Q
R

,

Q
R

≪

1
ϵ

1

ϵ

τ

2

9
8

ϵ

τ

2

2
+

τ

2

1

D
−
1

Q
R

D

D
−
1

1
+
O

ϵ

τ

2

Q
R

−

2

D
−
1

,

Q
R

≫

1
ϵ

,

1

ϵ

τ

2

which leads us to the double-scaling parameter, ϵ|τ|2QR, which interpolates between the “near-BPS phase” (∆(Q) ∼ Q) and the “superfluid phase” (∆(Q) ∼ QD/(D−1)) at large R-charge. This smooth transition, happening near τ = 0, is a large-R-charge manifestation of the existence of a moduli space and an infinite chiral ring at τ = 0. We also argue that this behavior can be extended to three dimensions with minimal modifications, and so we conclude that ∆(QR, τ) experiences a smooth transition around QR ∼ 1/|τ|2. Additionally, we find a first-order phase transition for ∆(QR, τ) as a function of τ, as a consequence of the duality of the model. We also comment on the applicability of our result down to small R-charge.
Causal representation of multi-loop Feynman integrands within the loop-tree duality
Authors: Aguilera-Verdugo J. Jesús , Hernández-Pinto Roger J. , Rodrigo Germán , Sborlini German F. R. , Torres Bobadilla William J. 
Published: January 2021

AbstractThe numerical evaluation of multi-loop scattering amplitudes in the Feynman representation usually requires to deal with both physical (causal) and unphysical (non-causal) singularities. The loop-tree duality (LTD) offers a powerful framework to easily characterise and distinguish these two types of singularities, and then simplify analytically the underling expressions. In this paper, we work explicitly on the dual representation of multi-loop Feynman integrals generated from three parent topologies, which we refer to as Maximal, Next-to-Maximal and Next-to-Next-to-Maximal loop topologies. In particular, we aim at expressing these dual contributions, independently of the number of loops and internal configurations, in terms of causal propagators only. Thus, providing very compact and causal integrand representations to all orders. In order to do so, we reconstruct their analytic expressions from numerical evaluation over finite fields. This procedure implicitly cancels out all unphysical singularities. We also interpret the result in terms of entangled causal thresholds. In view of the simple structure of the dual expressions, we integrate them numerically up to four loops in integer space-time dimensions, taking advantage of their smooth behaviour at integrand level.
Wilson-’t Hooft lines as transfer matrices
Authors: Maruyoshi Kazunobu , Ota Toshihiro , Yagi Junya 
Published: January 2021

AbstractWe establish a correspondence between a class of Wilson-’t Hooft lines in four-dimensional$$ \mathcal{N} $$N= 2 supersymmetric gauge theories described by circular quivers and transfer matrices constructed from dynamical L-operators for trigonometric quantum integrable systems. We compute the vacuum expectation values of the Wilson-’t Hooft lines in a twisted product spaceS1×ϵℝ2× ℝ by supersymmetric localization and show that they are equal to the Wigner transforms of the transfer matrices. A variant of the AGT correspondence implies an identification of the transfer matrices with Verlinde operators in Toda theory, which we also verify. We explain how these field theory setups are related to four-dimensional Chern-Simons theory via embedding into string theory and dualities.
BMS symmetry via AdS/CFT
Authors: Lowe David A. , Ramirez David M. 
Published: January 2021

Abstract
With a view to understanding extended-BMS symmetries in the framework of the AdS4/CFT3 correspondence, asymptotically AdS geometries are constructed with null impulsive shockwaves involving a discontinuity in superrotation parameters. The holographic dual is proposed to be a two-dimensional Euclidean defect conformal field localized on a particular timeslice in a three-dimensional conformal field theory on de Sitter spacetime. The defect conformal field theory generates a natural action of the Virasoro algebra. The large radius of curvature limit ℓ → ∞ yields spacetimes with nontrivial extended-BMS charges corresponding to a single set of Virasoro charges.
Socio-demographic factors associated with self-protecting behavior during the Covid-19 pandemic
Authors: Papageorge Nicholas W. , Zahn Matthew V. , Belot Michèle , van den Broek-Altenburg Eline , Choi Syngjoo , Jamison Julian C. , Tripodi Egon 
Published: January 2021

AbstractGiven the role of human behavior in the spread of disease, it is vital to understand what drives people to engage in or refrain from health-related behaviors during a pandemic. This paper examines factors associated with the adoption of self-protective health behaviors, such as social distancing and mask wearing, at the start of the Covid-19 pandemic in the USA. These behaviors not only reduce an individual’s own risk of infection but also limit the spread of disease to others. Despite these dual benefits, universal adoption of these behaviors is not assured. We focus on the role of socioeconomic differences in explaining behavior, relying on data collected in April 2020 during the early stages of the Covid-19 pandemic. The data include information on income, gender and race along with unique variables relevant to the current pandemic, such as work arrangements and housing quality. We find that higher income is associated with larger changes in self-protective behaviors. These gradients are partially explained by the fact that people with less income are more likely to report circumstances that make adopting self-protective behaviors more difficult, such as an inability to tele-work. Both in the USA and elsewhere, policies that assume universal compliance with self-protective measures—or that otherwise do not account for socioeconomic differences in the costs of doing so—are unlikely to be effective or sustainable.
A teaching tool about the fickle p value and other statistical principles based on real-life data
Authors: Alawbathani Salem , Batool Mehreen , Fleckhaus Jan , Hamad Sarkawt , Hassenrück Floyd , Hou Yanhong , Li Xia , Salmanton-García Jon , Ullah Sami , Wieters Frederique , Michel Martin C. 
Published: January 2021

AbstractA poor understanding of statistical analysis has been proposed as a key reason for lack of replicability of many studies in experimental biomedicine. While several authors have demonstrated the fickleness of calculated p values based on simulations, we have experienced that such simulations are difficult to understand for many biomedical scientists and often do not lead to a sound understanding of the role of variability between random samples in statistical analysis. Therefore, we as trainees and trainers in a course of statistics for biomedical scientists have used real data from a large published study to develop a tool that allows scientists to directly experience the fickleness of p values. A tool based on a commonly used software package was developed that allows using random samples from real data. The tool is described and together with the underlying database is made available. The tool has been tested successfully in multiple other groups of biomedical scientists. It can also let trainees experience the impact of randomness, sample sizes and choice of specific statistical test on measured p values. We propose that live exercises based on real data will be more impactful in the training of biomedical scientists on statistical concepts.
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
Authors: Lea Dordi , Watson Martin , Skaland Ivar , Hagland Hanne R. , Lillesand Melinda , Gudlaugsson Einar , Søreide Kjetil 
Published: January 2021

Abstract
Background
In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, the incurred expenses and copyrights may prevent universal use. The aim of this study was to develop a robust and objective quantification method of TILs in colon cancer.

Methods
A consecutive, unselected series of specimens from patients with colon cancer were available for immunohistochemistry and assessment of TILs by automated digital pathology. CD3 + and CD8 + cells at the invasive margin and in tumor center were assessed on consecutive sections using automated digital pathology and image analysis software (Visiopharm®). An algorithm template for whole slide assessment, generated cell counts per square millimeters (cells/mm2), from which the immune score was calculated using distribution volumes. Furthermore, immune score was compared with clinical and histopathological characteristics to confirm its relevance.

Results
Based on the quantified TILs numbers by digital image analyses, patients were classified into low (n = 83, 69.7%), intermediate (n = 14, 11.8%) and high (n = 22, 18.5%) immune score groups. High immune score was associated with stage I–II tumors (p = 0.017) and a higher prevalence of microsatellite instable (MSI) tumors (p = 0.030). MSI tumors had a significantly higher numbers of CD3 + TILs in the invasive margin and CD8 + TILs in both tumor center and invasive margin, compared to microsatellite stable (MSS) tumors.

Conclusion
A digital template to quantify an easy-to-use immune score corresponds with clinicopathological features and MSI in colon cancer.
Robot-Assisted Carotid Artery Stenting: A Safety and Feasibility Study
Authors: Jones Ben , Riga Celia , Bicknell Colin , Hamady Mohamad 
Published: January 2021

Abstract
Purpose
Endovascular robotics is an emerging technology within the developing field of medical robotics. This was a prospective evaluation to assess safety and feasibility of robotic-assisted carotid artery stenting.

Materials and Methods
Consecutive cases of carotid artery stenting cases performed over period of 24 months, from May 2015 to October 2016, using the Magellan Robotic System (Hansen, Mountain View, CA) were included. All cases utilised the robotic system to navigate the arch, obtain a stable position in the common carotid artery, followed by manual manipulation of Embolic Protection Devices and self-expandable stents through the robotic catheter. Patients demographics, clinical indications, anatomical features, technical and clinical success, complication rate and hospital stay were prospectively recorded.

Results
Thirteen patients, 10 males (78.5%), with an average age of 68.7 years were treated. Mean follow up time was 30 months. Ten patients (91%) were symptomatic at presentation. Anatomical indications for endovascular stent insertion were previous open surgery to the neck ± radiotherapy (87.5%) and hostile anatomy for open surgery (12.5%). Technical success was 100% and the robotic system demonstrates enhanced stability during arch and lesion crossing. There were no neurological complications post-operatively. Average hospital stay was 3 days (range 2–6 days) and a change in serum creatinine of −7.8 μmol/L. There was no documented case of in stent restenosis, new or worsening neurology during follow-up.

Conclusion
These results illustrate safety and feasibility of robotic endovascular revascularisation for carotid disease and demonstrates potential to enhance peri-procedural safety through improved control and stability.
Volumetric assessment of the periablational safety margin after thermal ablation of colorectal liver metastases
Authors: Laimer Gregor , Jaschke Nikolai , Schullian Peter , Putzer Daniel , Eberle Gernot , Solbiati Marco , Solbiati Luigi , Goldberg S. Nahum , Bale Reto 
Published: January 2021

Abstract
Objectives
To retrospectively assess the periablational 3D safety margin in patients with colorectal liver metastases (CRLM) referred for stereotactic radiofrequency ablation (RFA) and to evaluate its influence on local treatment success.

Methods
Forty-five patients (31 males; mean age 64.5 [range 31–87 years]) with 76 CRLM were treated with stereotactic RFA and retrospectively analyzed. Image fusion of pre- and post-interventional contrast-enhanced CT scans using a non-rigid registration software enabled a retrospective assessment of the percentage of predetermined periablational 3D safety margin and CRLM successfully ablated. Periablational safety zones (1–10 mm) and percentage of periablational zone ablated were calculated, analyzed, and compared with subsequent tumor growth to determine an optimal safety margin predictive of local treatment success.

Results
Mean overall follow-up was 36.1 ± 18.5 months. Nine of 76 CRLMs (11.8%) developed local tumor progression (LTP) with mean time to LTP of 18.3 ± 11.9 months. Overall 1-, 2-, and 3-year cumulative LTP-free survival rates were 98.7%, 90.6%, and 88.6%, respectively. The periablational safety margin assessment proved to be the only independent predictor (p < 0.001) of LTP for all calculated safety margins. The smallest safety margin 100% ablated displaying no LTP was 3 mm, and at least 90% of a 6-mm circumscribed 3D safety margin was required to achieve complete ablation.

Conclusions
Volumetric assessment of the periablational safety margin can be used as an intraprocedural tool to evaluate local treatment success in patients with CRLM referred to stereotactic RFA. Ablations achieving 100% 3D safety margin of 3 mm and at least 90% 3D safety margin of 6 mm can predict treatment success.

Key Points
• Volumetric assessment of the periablational safety margin can be used as an intraprocedural tool to evaluate local treatment success following thermal ablation of colorectal liver metastases.
• Ablations with 100% 3D periablational safety margin of 3 mm and ablations with at least 90% 3D safety margin of 6 mm can be considered indications of treatment success.
• Image fusion of pre- and post-interventional CT scans with the software used in this study is feasible and could represent a useful tool in daily clinical practice.
Manual therapy of infants with postural and movement asymmetries and positional preference
Authors: Sacher Robby , Knüdeler Martin , Wuttke Marc , Wüstkamp Nadine , Derlien Steffen , Loudovici-Krug Dana 
Published: January 2021

AbstractBackgroundThere are different therapeutic approaches to persistent positional preference (kinematic imbalance due to suboccipital strain, KISS) in infants. There are no evidence-based or controlled studies investigating the effect of manual medicine treatment in children aged 3–6 months, particularly in combination with a home exercise programme. The presented monocentric study on one-time manual medicine treatment of infants aged 14–24 exhibiting these symptoms aims to close this gap.MethodsThis study comprises a controlled double-blind trial and per-protocol-analysis. Primary outcome was the 4-item symmetry score (4–17 points). The second measurement was performed after 4–6 weeks.ResultsA total of 62 infants were treated and evaluated (mean age 17 weeks). The intervention and control groups started with a symmetry score of 12.9 ± 2.1 and 12.5 ± 1.7 points, respectively. In the intervention group the score improved by 4.9 ± 2.4 to 8.0 ± 2.7 points, in the control group it improved by 2.9 ± 2.9 to 9.6 ± 3.0 points. The difference between the groups was statistically significant (p = 0.03). Both groups had significantly better values over time (p < 0.001). No adverse events or side effects were observed.ConclusionManual medicine treatment of infants with postural and movement asymmetries as well as positional preference in combination with a home exercise programme is superior to a home exercise programme alone. Both treatment concepts achieved significant improvements. However, the manual medicine treatment played an important role in reducing the symmetry score value for the affected children, such they were no longer in need of treatment.
Winter Arctic Amplification at the synoptic timescale, 1979–2018, its regional variation and response to tropical and extratropical variability
Authors: Hall Richard J. , Hanna Edward , Chen Linling 
Published: January 2021

AbstractWe investigate winter Arctic Amplification (AA) on synoptic timescales and at regional scales using a daily version of the Arctic Amplification Index (AAI) and examine causes on a synoptic scale. The persistence, frequency and intensity of high AAI events show significant increases over the Arctic. Similarly, low AAI events are decreasing in frequency, persistence and intensity. In both cases, there are regional variations in these trends, in terms of significance and timing. Significant trends in increasing persistence, frequency and intensity of high AAI events in winter are concentrated in the period 2000–2009, with few significant trends before and after this. There are some decreases in sea-ice concentration in response to synoptic-scale AA events and these AA events can contribute to the decadal trends in AA found in other studies. A sectoral analysis of the Arctic indicates that in the Beaufort–Chukchi and East Siberian–Laptev Seas, synoptic scale high AAI events can be driven by tropical teleconnections while in other Arctic sectors, it is the intrusion of moisture-transporting synoptic cyclones into the Arctic that is most important in synoptic-scale AA. The presence of Rossby wave breaking during high AAI events is indicative of forcing from lower latitudes, modulated by variations in the jet stream. An important conclusion is that the increased persistence, frequency and intensity of synoptic-scale high AAI events make significant contributions to the interannual trend in AA.
Death in the sauna-vitality markers for heat exposure
Authors: Wegner Anja , Doberentz Elke , Madea Burkhard 
Published: January 2021

AbstractIn sauna-associated deaths, the vitality of heat exposure is of great importance. Two case reports address this. First, we present the case of a 77-year-old man who was found dead in the sauna of his family home. When found, the sauna door was closed, and the sauna indicated a temperature of 78 °C. The body had already begun to decay and was partially mummified when it was found. In the other case, a 73-year-old woman was found dead in the sauna by her husband. In this case, the sauna door was also closed. The sauna was still in operation at a temperature of approximately 70 °C. Epidermal detachments were found. In both autopsies and their follow-up examinations, there were no indications of a cause of death competing with heat shock. The expression of heat shock proteins in kidneys and lungs and the expression of aquaporin 3 in skin were investigated to detect pre-mortal temperature influences.
Subjective and objective demands on different types of differential stress inventory
Authors: Karlsen Håvard R. , Böckelmann Irina , Thielmann Beatrice 
Published: January 2021

Abstract
Purpose
To validate the differential stress inventory (DSI) by evaluating the objective and subjective stress differences in the five DSI types in the occupational setting.

Methods
A total of 119 German participants working as medical assistants (n = 40) or in a bank (n = 79) were recruited. They completed the Maslach Burnout Inventory–General Survey, the DSI, and wore ECG measuring devices for 24 h to measure heart rate variability. The DSI was used to group people into one of five types according to how they perceived and coped with stress: normal, overstressed, stress-resistant, low stress/high coping, or high stress/high coping.

Results
The overstressed type had significantly more burnout symptoms than the other types. The high stress/high coping type also had more symptoms of emotional exhaustion and total burnout compared to the other types, while the low stress/high coping and the stress-resistant types generally had the lowest levels of burnout. There were no differences on the HRV parameters among the DSI types.

Conclusion
Categorising people into types like in the DSI can help make workers aware of unhealthy stress and coping patterns before they turn into more severe pathology. Proper application and targeted preventive measures can save the individual’s health and the company’s budget. While the DSI picked up on differences in burnout symptoms as a long-term consequence of stress, there is evidence that it cannot pick up on short-term stress or physical stress as measured by HRV from the 24 h recording.
The development of mature gait patterns in children during walking and running
Authors: Bach Margit M. , Daffertshofer Andreas , Dominici Nadia 
Published: January 2021

Abstract
Purpose
We sought to identify the developing maturity of walking and running in young children. We assessed gait patterns for the presence of flight and double support phases complemented by mechanical energetics. The corresponding classification outcomes were contrasted via a shotgun approach involving several potentially informative gait characteristics. A subsequent clustering turned out very effective to classify the degree of gait maturity.

Methods
Participants (22 typically developing children aged 2–9 years and 7 young, healthy adults) walked/ran on a treadmill at comfortable speeds. We determined double support and flight phases and the relationship between potential and kinetic energy oscillations of the center-of-mass. Based on the literature, we further incorporated a total of 93 gait characteristics (including the above-mentioned ones) and employed multivariate statistics comprising principal component analysis for data compression and hierarchical clustering for classification.

Results
While the ability to run including a flight phase increased with age, the flight phase did not reach 20% of the gait cycle. It seems that children use a walk-run-strategy when learning to run. Yet, the correlation strength between potential and kinetic energies saturated and so did the amount of recovered mechanical energy. Clustering the set of gait characteristics allowed for classifying gait in more detail. This defines a metric for maturity in terms of deviations from adult gait, which disagrees with chronological age.

Conclusions
The degree of gait maturity estimated statistically using various gait characteristics does not always relate directly to the chronological age of the child.