bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability Issues, Probable Approaches for Stabilization and Associated
Patents in the Pharmaceutical Field for Oleosome, A Novel Carrier for
Drug Delivery
Authors: Ashique Sumel , Singh Ajmer , Sandhu Navjot K. 
Published: March 2021

Abstract:
Oleosomes are oil-containing micro-carriers of natural origin that are comprised of
special oleosin proteins embedded with a monolayer of phospholipids having a triacylglycerol
core. Due to their unique structure and non-toxicity in the biological system, these oil carriers are
becoming very eye-catching for formulation development in the field of pharmacy. Consequently,
oleosome offers emoliency, occlusivity, self-emulsification, anti-oxidant, and film-forming
properties, which leads to controlled and sustained release of encapsulated bio-actives. It is also
feasible to load oil-soluble ingredients, such as fragrance, vitamins (retinol), and lipophilic drug
moieties inside the core. Being a natural carrier, it shows some stability issues (leakage of oil
from the core, oxidation of the loaded oil, aggregation of oil droplets), which are controllable. In
this review, we have focused on the various stability issues, the techniques (coating, surface
modification, solvents) and how to overcome those problems, and how to load any lipophilic
drug into the oil core, and we have also linked patent research works in the field of formulation
development.
Measurement of the Hygric Resistance of Concrete Blocks with Perfect Contact Interface: Influence of the Contact Area
Authors: Azevedo António C. , Delgado João M.P.Q. , Silva Klayne.K.S. , Leal André L.M.S. , Guimarães Ana S. , Ribeiro Isabel 
Published: March 2021

Introduction:
Concrete sealing blocks are not only used in Brazil but worldwide. T he knowledge of the material properties in the presence of moisture becomes necessary to study the durability of buildings.

Methods:
An experimental study was carried out in order to analyse the effect of contact area on the capillary absorption coefficient of concrete samples used in sealing blocks, according to several standards: NBR 9779 (2012), EN 1015-18 (2002), ISO 15148 (2002) and ASTM C1794 (2015). Two types of specimens were analysed; monolithic samples and samples with a perfect contact interface. The monolithic samples were also subjected to axial and radial compression in order to enhance the capacity of masonry.

Results:
The experimental results for the samples with perfect contact interface indicate that the water absorption before the interface presents similar behaviour to the monolithic samples. However, it is possible to observe a reduction of the absorption rate when water reaches the interface due to the hygric resistance. In other words, the moisture transport is significantly retarded by the existence of an interface, i.e., the discontinuity of moisture content across the interface indicated that there was a difference in capillary pressure across the interface. Also, the interface contact area does not greatly influence the water-resistance values.

Conclusion:
Finally, the Hygric Resistance values (HR), in multilayer building components, with perfect contact interface are calculated using the “knee point” methodology.
Middle East Preferred Practice Patterns for Dry Eye Disease: A Modified Delphi Consensus
Authors: Al-Maskari Ahmed Z. , Alarfaj Khalid , Shaheen Mohamed S. , Al-Yousuf Nada , Giledi Osama , Algehedan Saeed , Navon Sam , Lazreg Sihem 
Published: March 2021

Background: Dry Eye Disease (DED) is a common ophthalmic condition resulting from dysfunction in the ocular surface, main lacrimal gland, meibomian glands, or connecting nerves.

Objective: A group of local experts met to discuss local challenges and establish consensus in DED management across the Middle East.

Methods: A modified Delphi method was used to reach consensus, comprising two rounds of the survey and a face-to-face meeting. An expert panel of 8 ophthalmologists voted on 23 statements, with consensus reached if ≥75% responded “strongly agree” or “agree” to a statement.

Results: The expert panel reached consensus on 23 statements relating to the pathophysiology, diagnosis, treatment, and management of DED. Diagnosis begins with recording a detailed patient history and assessing subjective symptoms such as redness, burning, stinging, foreign body sensation, and/or photophobia. Tear Break-up Time (TBUT; <10 s), corneal spots (>5), and fluorescein staining are essential for diagnosing DED, assessing disease severity and ocular surface condition, and differentiating between types of DED. Ocular surface lubricants are the mainstay of treatment for DED. Treatment approaches should be categorized by etiology (if known). An improvement in symptoms can be observed objectively via an increase in TBUT, reduction in corneal and conjunctival spots, and restoration of normal tear production, or subjectively via less dependence on ocular surface lubricants, improved vision quality, and symptom amelioration.

Conclusion: This consensus will serve to provide a framework for clinical decisions relating to the management of DED across the region.
Role of Age and Sex on Simple and Complex Carbohydrates Rich Foods Consumption and Thyroid Cancer Risk: Hospital Based Case - Control Study
Authors: Fiore Maria , Cristaldi Antonio , Okatyeva Valeria , Lo Bianco Salvatore , Conti Gea Oliveri , Zuccarello Pietro , Copat Chiara , Caltabiano Rosario , Cannizzaro Matteo , Ferrante Margherita 
Published: March 2021

Background:
The risk of thyroid cancer has already been related to diet/carbohydrates rich foods, but the association has not been investigated in terms of age and sex implications.

Objective:
We studied the relationship between thyroid cancer and the consumption of simply and complex carbohydrates rich foods, mainly investigating the possible predictive role of age and sex.

Methods:
We analyzed data from a hospital case-control study conducted in Italy from 2015 to 2018, including 106 cases of thyroid cancer and 121 controls. The consumption of simple and complex carbohydrates rich foods was investigated through the validated Lifestyles Questionnaire using a 4-level scale (never, 1 time per week, 2–3 times a week, 6 times a week). Statistical data analysis was conducted using the IBM SPSS Statistics 21.0 program.

Results:
We found a moderate negative correlation between simple carbohydrates rich foods consumption and age (rho= -0.364, p:0.00), particularly in females (females: rho= -0.374, p:0.00; males: rho=-0.266, p=0.036). A weak positive correlation was found between age and complex carbohydrates-rich foods only in males (rho= 0.244, p=0.054). The Two-Way Analysis of Variance confirmed that, overall, simple carbohydrates rich foods consumption decreased with age categories (Case: F=2.59, p=0.032; Control: F=3.14, p=0.011), although it remains higher for female than male cases at all age categories (≤38, 39-52, 53+years). Conversely the complex carbohydrates rich foods intake had interaction with age categories only in controls group (Control: F=1.95, p=0.09; Case: F=0.744, p=0.592), where based on sex, it remains higher for female than male at ≤38 and 39-52 age categories. It should be emphasized that in category ≤38 we had only one male cases.

Conclusion:
Our study adds new and relevant information to support the hypothesis that age and sex could impact the thyroid cancer risk by their involvement in simple carbohydrates rich foods consumption. Therefore, future interventions are needed for an understanding of the pathophysiological associations between only carbohydrates rich foods intake and thyroid cancer, mainly for older and female populations, and also for the improvement of preventive public health policies and “Gender Medicine”.
Online Tool for the Assessment of the Burden of COVID-19 in Patients: Development Study
Authors: van Noort Esther M J , Claessens Danny , Moor Catharina C , Berg Carlijn A L Van Den , Kasteleyn Marise J , in 't Veen Johannes C C M , Van Schayck Onno C P , Chavannes Niels H 
Published: March 2021

Background
The impact of COVID-19 has been felt worldwide, yet we are still unsure about its full impact. One of the gaps in our current knowledge relates to the long-term mental and physical impact of the infection on affected individuals. The COVID-19 pandemic hit the Netherlands at the end of February 2020, resulting in over 900,000 people testing positive for the virus, over 24,000 hospitalizations, and over 13,000 deaths by the end of January 2021. Although many patients recover from the acute phase of the disease, experience with other virus outbreaks has raised concerns regarding possible late sequelae of the infection.

Objective
This study aims to develop an online tool to assess the long-term burden of COVID-19 in patients.

Methods
In this paper, we describe the process of development, assessment, programming, implementation, and use of this new tool: the assessment of burden of COVID-19 (ABCoV) tool. This new tool is based on the well-validated assessment of burden of chronic obstructive pulmonary disease tool.

Results
As of January 2021, the new ABCoV tool has been used in an online patient platform by more than 2100 self-registered patients and another 400 patients in a hospital setting, resulting in over 2500 patients. These patients have submitted the ABCoV questionnaire 3926 times. Among the self-registered patients who agreed to have their data analyzed (n=1898), the number of females was high (n=1153, 60.7%), many were medically diagnosed with COVID-19 (n=892, 47.0%), and many were relatively young with only 7.4% (n=141) being older than 60 years. Of all patients that actually used the tool (n=1517), almost one-quarter (n=356, 23.5%) used the tool twice, and only a small group (n=76, 5.0%) used the tool 6 times.

Conclusions
This new ABCoV tool has been broadly and repeatedly used, and may provide insight into the perceived burden of disease, provide direction for personalized aftercare for people post COVID-19, and help us to be prepared for possible future recurrences.
Blockchain Personal Health Records: Systematic Review
Authors: Fang Hao Sen Andrew , Tan Teng Hwee , Tan Yan Fang Cheryl , Tan Chun Jin Marcus 
Published: March 2021

Background
Blockchain technology has the potential to enable more secure, transparent, and equitable data management. In the health care domain, it has been applied most frequently to electronic health records. In addition to securely managing data, blockchain has significant advantages in distributing data access, control, and ownership to end users. Due to this attribute, among others, the use of blockchain to power personal health records (PHRs) is especially appealing.

Objective
This review aims to examine the current landscape, design choices, limitations, and future directions of blockchain-based PHRs.

Methods
Adopting the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines, a cross-disciplinary systematic review was performed in July 2020 on all eligible articles, including gray literature, from the following 8 databases: ACM, IEEE Xplore, MEDLINE, ScienceDirect, Scopus, SpringerLink, Web of Science, and Google Scholar. Three reviewers independently performed a full-text review and data abstraction using a standardized data collection form.

Results
A total of 58 articles met the inclusion criteria. In the review, we found that the blockchain PHR space has matured over the past 5 years, from purely conceptual ideas initially to an increasing trend of publications describing prototypes and even implementations. Although the eventual application of blockchain in PHRs is intended for the health care industry, the majority of the articles were found in engineering or computer science publications. Among the blockchain PHRs described, permissioned blockchains and off-chain storage were the most common design choices. Although 18 articles described a tethered blockchain PHR, all of them were at the conceptual stage.

Conclusions
This review revealed that although research interest in blockchain PHRs is increasing and that the space is maturing, this technology is still largely in the conceptual stage. Being the first systematic review on blockchain PHRs, this review should serve as a basis for future reviews to track the development of the space.
Enhancing Obstructive Sleep Apnea Diagnosis With Screening Through Disease Phenotypes: Algorithm Development and Validation
Authors: Ferreira-Santos Daniela , Rodrigues Pedro Pereira 
Published: March 2021

Background
The American Academy of Sleep Medicine guidelines suggest that clinical prediction algorithms can be used in patients with obstructive sleep apnea (OSA) without replacing polysomnography, which is the gold standard.

Objective
This study aims to develop a clinical decision support system for OSA diagnosis according to its standard definition (apnea-hypopnea index plus symptoms), identifying individuals with high pretest probability based on risk and diagnostic factors.

Methods
A total of 47 predictive variables were extracted from a cohort of patients who underwent polysomnography. A total of 14 variables that were univariately significant were then used to compute the distance between patients with OSA, defining a hierarchical clustering structure from which patient phenotypes were derived and described. Affinity from individuals at risk of OSA phenotypes was later computed, and cluster membership was used as an additional predictor in a Bayesian network classifier (model B).

Results
A total of 318 patients at risk were included, of whom 207 (65.1%) individuals were diagnosed with OSA (111, 53.6% with mild; 50, 24.2% with moderate; and 46, 22.2% with severe). On the basis of predictive variables, 3 phenotypes were defined (74/207, 35.7% low; 104/207, 50.2% medium; and 29/207, 14.1% high), with an increasing prevalence of symptoms and comorbidities, the latter describing older and obese patients, and a substantial increase in some comorbidities, suggesting their beneficial use as combined predictors (median apnea-hypopnea indices of 10, 14, and 31, respectively). Cross-validation results demonstrated that the inclusion of OSA phenotypes as an adjusting predictor in a Bayesian classifier improved screening specificity (26%, 95% CI 24-29, to 38%, 95% CI 35-40) while maintaining a high sensitivity (93%, 95% CI 91-95), with model B doubling the diagnostic model effectiveness (diagnostic odds ratio of 8.14).

Conclusions
Defined OSA phenotypes are a sensitive tool that enhances our understanding of the disease and allows the derivation of a predictive algorithm that can clearly outperform symptom-based guideline recommendations as a rule-out approach for screening.
Information and Communication Technology Use in Suicide Prevention: Scoping Review
Authors: Rassy Jessica , Bardon Cécile , Dargis Luc , Côté Louis-Philippe , Corthésy-Blondin Laurent , Mörch Carl-Maria , Labelle Réal 
Published: March 2021

Background
The use of information and communication technology (ICT) in suicide prevention has progressed rapidly over the past decade. ICT plays a major role in suicide prevention, but research on best and promising practices has been slow.

Objective
This paper aims to explore the existing literature on ICT use in suicide prevention to answer the following question: what are the best and most promising ICT practices for suicide prevention?

Methods
A scoping search was conducted using the following databases: PubMed, PsycINFO, Sociological Abstracts, and IEEE Xplore. These databases were searched for articles published between January 1, 2013, and December 31, 2018. The five stages of the scoping review process were as follows: identifying research questions; targeting relevant studies; selecting studies; charting data; and collating, summarizing, and reporting the results. The World Health Organization suicide prevention model was used according to the continuum of universal, selective, and indicated prevention.

Results
Of the 3848 studies identified, 115 (2.99%) were selected. Of these, 10 regarded the use of ICT in universal suicide prevention, 53 referred to the use of ICT in selective suicide prevention, and 52 dealt with the use of ICT in indicated suicide prevention.

Conclusions
The use of ICT plays a major role in suicide prevention, and many promising programs were identified through this scoping review. However, large-scale evaluation studies are needed to further examine the effectiveness of these programs and strategies. In addition, safety and ethics protocols for ICT-based interventions are recommended.
Kielihäiriöisten lasten korjausaloitteet tarkastelussa
Authors: Haakana Markku , Lilja Niina 
Published: March 2021

Arvioitu teos:
Inkeri Salmenlinna: Kielihäiriöisten lasten korjausaloitteet puheterapia- ja leikkivuorovaikutuksessa.Helsinki: Helsingin yliopisto 2020. 208 s. isbn 978-951-51-6428-5. Saatavilla verkossa osoitteessa http://urn.fi/URN:ISBN:978-951-51-6429-2.
Analisis Kualitas Geometri Mesin Bubut Maximat Super 11
Authors: Indrawan Eko , A Yufrizal , Aziz Abdul , Rifelino Rifelino , Tawakal Muhammad Iqbal 
Published: March 2021

Penelitian ini bertujuan sejauh mana tingkat kepresisian dari mesin bubut maximat super 11 di Laboratorium Teknologi Produksi. Pengumpulan data dilakukan pengujian putaran (run out) spindle nose, pengujian ketirusan lubang spindle nose, pengujian kelurusan tailstock guideways terhadap gerakan eretan dan pengujian kebulatan terhadap benda kerja dalam pembubutan rata. Hasil penelitian pengujian putaran (run out) spindle nose masih dalam batas toleransi yang ditetapkan schlesinger standart (0.01 mm), pengujian ketirusan lubang spindle nose hampir secara keselurahan mesin sudah melewati batas penyimpangan yang diizinkan (posisi A = 0.01 mm, posisi B = 0.02 mm per 30 mm), pengujian kelurusan lintasan semua mesin sudah melewati batas penyimpangan (0.01 mm per 500 mm) dan dicobakan untuk pembubutan rata pada benda kerja (spesimen) ditentukan untuk 2 mesin dengan penyimpangan terkecil (M17) dan terbesar (M20) dari keseluruhan mesin dan setelah diuji tingkat kebulatan dari kedua benda disimpulkan masih dalam batas toleransi yang diizinkan (0.015 mm per 120 mm).
Analisis Pemetaan Kemampuan Numerik Siswa SMK Model Teori Respon Butir
Authors: Matondang Panyahuti , Jalinus Nizwardi , Ambiyar Ambiyar 
Published: March 2021

Pada Sekolah Menengah Kejuruan, matematika memainkan peran penting untuk menguasai mata pelajaran yang berhubungan dengan ilmu-ilmu keteknikan dan sains. Salah satu kemampuan terpenting dalam matematika adalah kemampuan berhitung (numerik). Kemampuan numerik yang baik akan mempermudah siswa untuk mempelajari mata pelajaran lainnya disekolah. Penelitian ini dilakakukan berdasarkan rendahnya kemampuan siswa SMK khususnya kemampuan numerik siswa SMK yang mendukung pelajaran keteknikan. Tujuan penelitian ini adalah untuk mengetahui kesahihan alat ukur yang digunakan sekolah untuk menguji kemampuan numerik siswa. Analisis dilakukan terhadap parameter item dari tes kemampuan numerik (kesulitan & daya beda) nilai yang dapat diterima, butir-butir soal-soal numerik yang efektif untuk digunakan untuk pengukuran, tingkat kesesuaian butir soal (item fit), dan indikator validitas uji kemampuan numerik. Penelitian ini adalah penelitian ex post facto, Teknik analisis data yang digunakan adalah analisis data secara kuantitatif pendekatan teori respon butir model logistik dua parameter dengan menggunakan bahasa pemrograman R, eirt dan SPSS. Hasil analisis akan membantu sekolah dalam membuat program-program yang lebih efektif untuk meningkatkan hasil belajar siswa. Butir-butir soal yang ada, efektif untuk digunakan dalam pengukuran, dibuktikan dengan hasil korelasi Item-Total signifikan untuk semua butir soal. Penelitian di masa depan diharapkan sebuah tes dapat memetakan kemampuan siswa secara baik pada dimensi pengetahuan taxonomy bloom dan variable-variabel kemampuan numerik lainnya.
Implementasi Pompa Air Tenaga Surya Menggunakan Inverter Boost Satu Fasa
Authors: Yuhendri Muldi , Aswardi Aswardi , Ahyanuardi Ahyanuardi 
Published: March 2021

Pompa air tenaga surya adalah salah satu alternatif penyediaan air bersih untuk daerah yang belum terjangkau jaringan listrik. Pompa air tenaga surya membutuhkan peralatan yang dapat menaikan tegangan panel surya sesuai dengan rating tegangan motor pompa air dan inverter untuk mengkonversikan tegangan dc panel surya menjadi tegangan ac sesuai dengan tegangan motor pompa air. Paper ini mengusulkan inverter boost satu fasa untuk pompa air tenaga surya yang dapat menaikan sekaligus mengkonversikan tegangan dc menjadi tegangan ac tanpa menggunakan transformator. Modulasi inverter dirancang menggunakan metode Sinusoidal Pulse Width Modulation (SPWM) yang diimplementasikan dengan arduino uno. Pompa air tenaga surya diimplementasikan untuk penyediaan air bersih di Mesjid dengan menggunakan panel surya 300 WP. Hasil pengujian di lapangan menunjukan bahwa pompa air tenaga surya yang diusulkan telah bekerja dengan baik sesuai dengan yang diharapkan. Inverter boost satu fasa yang diusulkan telah dapat mengkonversikan tegangan panel surya sesuai dengan rating tegangan motor pompa air.
PENGARUH PENGGUNAAN MODEL PEMBELAJARAN PROBLEM BASED INSTRUCTION (PBI) TERHADAP HASIL BELAJAR PESERTA DIDIK DALAM PEMBELAJARAN BIOLOGI
Authors: Novianti Ni Kadek Dewi , Santoso Handoko , Lepiyanto Agil 
Published: March 2021

The Effect of using the Problem Based Instruction (PBI) learning model to determine the effect on learning outcomes using the Problem Based Instruction (PBI) learning process. This research is a quasi experimental research which consists of a control class and an experimental class. The control class uses the conventional learning model and the experimental class uses the Problem Based Instruction (PBI) learning model, conducted in the X MIPA 1 and X MIPA 2 in SMA Negeri 1 Rumbia. The research data were obtained from test sheets and observations at the end of each lesson. The average cognitive learning outcomes of the experimental class were 80% and the control class was 63,83%. The average psychomotor learning outcomes of the experimental class were 80,46% and the experimental class was 75%. The results showed that there was an influence of the Problem Based Instruction (PBI) learning model on the learning outcomes of students in learning biology. Kata Kunci : Model Pembelajaran Problem Based Instruction (PBI), Hasil, Belajar peserta didik