bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of TNFRSF7 and TNFRSF9 receptors in the development of systemic inflammation in patients with viral pneumonia
Authors: Малярчиков А.В. , Шаповалов К.Г. 
Published: November 2021

Актуальность. Системный про- и противовоспалительный каскад реакций является одним из патофизиологических компонентов развития критического состояния различного генеза. Поиск биологических маркёров и патогенетических механизмов влияния на макроорганизм систем рецепторов, участвующих в реализации реакций врожденного и адаптивного иммунитета, вследствие повреждения или инфекции, остается актуальным научным направлением. Цель исследования. Оценить активность системы рецепторов TNFRSF7 и TNFRSF9, определив их плазменную концентрацию у больных пневмониями на фоне гриппа A/H1N1. Материалы и методы. Обследовали 85 больных пневмонией на фоне гриппа A/H1N1. Из них 30 пациентов с тяжёлой пневмонией, 55 - с нетяжёлой пневмонией. Методом проточной цитофлуометрии определяли плазменную концентрацию молекул TNFRSF7 и TNFRSF9. Результаты. Установили, что что у больных тяжёлой пневмонией на фоне гриппа A/H1N1 плазменная концентрация рецепторов TNFRSF7 и TNFRSF9 увеличивалась в 1,8 и в 2,3 раза соответственно. Заключение. Увеличение концентрации TNFRSF7 и TNFRSF9 у больных пневмониями на фоне гриппа A/H1N1 свидетельствует о вовлечении в реализацию реакций врожденного и адаптивного иммунитета суперсемейства рецепторов TNF и ассоциировано с тяжестью состояния.
Background. Systemic pro- and anti-inflammatory cascades of reactions are pathophysiological components of various critical states. It remains relevant to search for biological markers and pathogenetic mechanisms of effects on the macro-organism of receptor systems involved in innate and adaptive immunity induced by damage or infection. Aim of the study. To evaluate the activity of the TNFRSF7 and TNFRSF9 receptor systems by determining their plasma concentrations in pneumonia patients with influenza A (H1N1). Materials and methods. 85 patients with pneumonia associated with influenza A (H1N1) were examined. Among them, 30 patients had severe pneumonia, and 55 patients had non-severe pneumonia. Plasma levels of TNFRSF7 and TNFRSF9 were measured by flow cytometry. Results. In patients with severe pneumonia and underlying influenza A (H1N1), the plasma concentrations of TNFRSF7 and TNFRSF9 receptors increased 1.8-fold and 2.3-fold, respectively. Conclusion. The significant increase in plasma TNFRSF7 and TNFRSF9 receptors in patients with pneumonia associated with influenza A (H1N1) indicates the involvement of the TNF receptor superfamily in innate and adaptive immunity reactions and is related with severity of the disease.
USE OF PROTEIN-CONTAINING GELLING AGENT FOR THE PRODUCTION OF JELLY PRODUCTS OF A FUNCTIONAL ORIENTATION
Authors: КРЫЛОВА Э.Н. , КОНДРАТЬЕВ Н.Б. , СВЯТОСЛАВОВА И.М. , МАВРИНА E.Н. 
Published: November 2021

Разработана технология желейных изделий (ЖИ) с использованием белоксодержащего студнеобразователя – желатина для повышения их пищевой ценности и снижения содержания сахара. Был использован желатин марки П-11 с прочностью студня 1100 Н. Определены оптимальные соотношения рецептурных компонентов – патоки и желатина, который вносили в желейные массы в количестве 4, 6 и 8% по массе выхода желейной массы, и параметры технологического процесса получения ЖИ на желатине. Установлено, что оптимальным является добавление 20–25% патоки. Содержание редуцирующих веществ при этом составляет 12%. Определено, что пластическая прочность корпусов ЖИ, необходимая для их дальнейшей обработки, составляет 16 кПа. Она достигается при добавлении 8% желатина по массе выхода желейной массы в массу влажностью (23 ± 1)% и температуре формования 65–70°С за 45–50 мин выстаивания при температуре 8–10°С. Определены показатели пищевой, г на 100 г продукта: белки 6,6; жиры 8,7; углеводы 52,2 и энергетической ценности 100 г продукта – 1391,9/333 кДж/ккал разработанных ЖИ. Пищевая ценность желейных изделий на желатине, полученных по разработанной технологии, повысилась в пять раз за счет увеличения количества белка до 6,6%, а их сахароемкость снижена более чем на 16,0% по сравнению с аналогичными показателями ЖИ на агаре. Технология разработана с учетом использования действующих поточно-механизированных линий.
The technology of jelly products (JP) using a protein-containing gelling agent – gelatin to increase their nutritional value and reduce sugar content is developed. P-11 grade gelatin with jelly strength of 1100 H has been used. The optimal ratio of the formulation components-molasses and gelatin, which was introduced into the jelly mass in an amount of 4, 6 and 8% by weight of the jelly mass yield, and the parameters of the technological process of producing JP on gelatin are determined. It is established that the addition of 20–25% molasses is optimal. The content of reducing substances in this case is 12%. It is determined that the plastic strength of cases of confectionery, necessary for their further processing, is 16 kPa. It is achieved by adding 8% gelatin by weight of the jelly mass in the mass of moisture (23 ± 1)% and molding temperature 65–70°C for 45–50 min of standing at a temperature of 8–10°C. Indicators of food, g per 100 g of product: proteins 6,6; fats 8,7; carbohydrates 52,2 and energy value of 100 g of product – 1391,9/333 kJ / kcal of the developed products are defined. The nutritional value of jelly products on gelatin obtained by the developed technology increased five times due to an increase in the amount of protein to 6,6%, and their sugar content was reduced by more than 16,0% compared to similar indicators of JP on agar. The technology is developed taking into account the use of operating flow-mechanized lines.
Estudio del sistema de refrigeración en la conservación de la leche en el valle del Mantaro
Authors: Morales Quispe Hugo 
Published: November 2021

El presente trabajo, viene a ser una preocupación mayoritaria sobre un producto de consumo masivo y una actividad preponderante en el valle del Mantaro, siendo la agricultura y la ganadería, en el sector rural, la más visible.
La leche es un producto lácteo, para este caso, derivado de la vaca, requiere de un tratamiento riguroso en todas sus etapas, debido a la presencia de microorganismos que se encuentran en el medio ambiente.
La conservación está orientada desde el primer momento en la obtención de la leche, mediante un proceso en la que llega a temperaturas mayores de 30 °C, luego es enfriado por distintos métodos hasta 15 °C y 13 °C. La temperatura debe llegar a 4 °C o 5 °C para su transporte y comercialización adecuada. Desde el punto de vista de la conservación de temperaturas menores al medio ambiente, son necesarios herramientas, como la refrigeración, para resolver el problema de llegar a temperaturas menores.
En la primera parte del trabajo, se presenta el marco teórico referencial, el cual permitió tener una visión panorámica del trabajo, planteándose luego el problema, para luego abarcar, con el desarrollo del tema, estudios de la cadena productiva de la leche y el estudio estadístico del comportamiento poblacional, especialmente en los centros de producción lechera del área de estudio. En la parte central, se tomó el estudio especializado sobre ingeniería de refrigeración, llegando a determinar las características del equipamiento básico necesario de una planta de frío para conservar la leche en óptimas condiciones. La metodología utilizada es de análisis y síntesis con el soporte de estudios estadísticos a fin de tener una posición más cercana a la realidad. Se consolida el trabajo con los aportes, conclusiones y recomendaciones necesarios
Traditional and digital cyberbulling prevention
Authors: Vikhman A. A. , Volkova E. N. , Skitnevskaya L. V. 
Published: November 2021

Introduction. The prevalence of information technology and the availability of the Internet have led to the emergence of a new form of bullying – cyberbullying. Cyberbullying is harassment that occurs through the use of technology (computer, mobile phones) and the Internet (e-mail, social networks, messengers). Unlike direct, contact forms of bullying, it has a number of specific properties such as: anonymity; distance; a large number of witnesses and uncontrolled dissemination of information provided by the Internet.Materials and Methods. The article presents a theoretical overview of the directions of prevention of cyberbullying. In the process of scientific search, theoretical research methods were used: comparative analysis, generalization, interpretation.Results. Taking into account the discussion about the similarities and differences between traditional bullying and cyberbullying, both traditional forms of joint prevention of aggression offline and online, as well as specific digital opportunities for assistance and support to victims of cyber aggression are highlighted.Anti-bullying programs, taking into account the role structure and complexity of influence, have proven their effectiveness in the situation of cyberbullying. Particular attention is paid to individual personal resources, the development or correction of which reduces the risk of cyber-victimization and cyber-aggression, facilitates coping with cyber-aggression and mitigates its negative consequences. Such personal resources include emotional intelligence and resilience, the ability to empathy, responsibility, moral and moral feelings, a sense of gratitude, emotions of forgiveness, balanced self-esteem, self-esteem, values of friendship and cohesion, controlled anger and temper, openness to new experiences and adaptive coping strategies with difficulties.The specific characteristics (the use of computer technology, anonymity, disinhibition) of cyberbullying allow the use of digital opportunities for its prevention: reducing the computer dependence of cyberbullying participants and redirecting unproductive activity on the Internet to the experience and skills of digital socialization, health-saving digital technologies, coping with online risks, parental control over the use of the Internet and the formation of Internet etiquette.Discussion and Conclusions. Unlike traditional forms of bullying, the digital environment itself can be an effective resource for preventing cyberbullying and mitigating its consequences. Victims of cyber aggression prefer to receive anonymous help via the Internet, and this makes cyberspace an ideal place for prevention and assistance in an online form.In general, the resource direction of prevention is the systematic tactical development of social, emotional, communicative and digital skills, as well as the strategic search and development of individual personal resources.
Children's vision of the covid-19 pandemic: gender-specific views of older preschoolers and younger schoolchildren
Authors: Semenova L. E. , Semenova V. E. , Koneva I. A. , Karpushkina N. V. 
Published: November 2021

Introduction.This article presents the results of the research project "Children's Vision of the COVID-19 pandemic" implemented in 2020. According to many experts, the COVID-19 pandemic has led to negative consequences for the physical (somatic), psychic and psychological and the health of the population. The works of foreign and domestic authors state the facts of a number of negative psychological effects of an emotional, mental and behavioral nature. However, against the background of the available research, a significant gap is found, which concerns the children's version of the perception of the situation of the pandemic and forced isolation, and above all its gender specificity in relation to the stage of early ontogenesis – senior preschool and primary school age.Materials and Methods.To collect the actual data, a projective verbal method of writing a story on the theme "The Tale of the Coronavirus" was used. In total, 138 stories were collected (68 of them were composed by girls and 70 by boys), the content analysis of which was carried out through the open coding procedure. Comparative gender analysis of the texts of the stories was conducted in seven main categories: "characteristics of the coronavirus", "origin of the coronavirus", "current (frustrated) needs", "resources for overcoming difficulties", "emotions", "key events" and "gender of the characters".Results.The data obtained showed the predominantly negative nature of children's views of the coronavirus, pronounced discomfort in most of them caused by frustration of the needs for security, freedom, positive emotions and social contacts, the predominance of a mostly anxious emotional background of the perception of the pandemic situation with a predominance of fear, as well as a special emphasis on such resources for overcoming difficulties as compliance with preventive measures and hygiene rules, medical care and restriction of activity. At the same time, the gender specificity of children's ideas about the COVID-19 pandemic was found, which consists in a more pronounced orientation towards people of their own sex, emphasizing their own role in solving the problem and focusing on active resistance to the threat in boys and focusing on the emotional side of events, emphasizing the role of others and waiting for salvation from outside in girls.Discussion and Conclusions.According to the results of the study, it is concluded that the content of ideas about the COVID-19 pandemic and self-isolation of girls and boys of senior preschool and primary school age, along with general trends, has a gender specificity, which reflects the results of differentiated gender socialization prevailing at the stages of early ontogenesis, based on the tradition of gender polarization.
Analysis of domestic and foreign trends of individualization of the educational process in the university: analytical report
Authors: Arifulina R. U. , Katushenko O. A. 
Published: November 2021

Introduction. The individualization of the education process is today one of the priority directions of the transformation of the higher education system, which involves the creation of conditions for the implementation of the educational opportunities of students, their academic mobility, the design of an individual educational trajectory, i.e. on the one hand, it serves as a tool for fulfilling the state order in the formation of a competitive specialist, and on the other hand, it allows you to maximally orient education to the personality of the student.Materials and Methods. The article considers domestic and foreign research materials aimed at organizing and implementing the individualization of the learning process. The work uses methods of analysis of scientific literature, questionnaires, analysis, generalization and systematization of data.Results. The authors identified and described the main trends in the development of individualization of the educational process, the relationship between the concepts of "individual educational route" and "individual educational trajectory". A comparative analysis of the results of a questionnaire survey of teachers and students on the problem of individualization of education is carried out, and the main models of individualization of the educational process are highlighted.Discussion and Conclusions. As challenges for the individualization of the educational process of higher pedagogical education, the authors see the bridging of the "digital divide" arising from the inequality in access to digital tools between the subjects of the educational space of the university, as well as regions and countries; updating the goals and content of education, as well as forms, methods and technologies of organizing the educational process; changing approaches and tools to assessing the competencies and educational results of students in the course of mastering an individual educational route; changing the roles of the subjects of the educational process.
Studying the importance of the sense of coherence in the formation of mindfulness and assessment of its changes in persons with different health levels
Authors: Mikhalchi E. V. 
Published: November 2021

Introduction. The article presents the results of studying the meaning of a sense of coherence in the formation of mindfulness, as a personality trait, aimed at full perception and retention of attention on changes in the environment in persons with different levels of health. The objectives of the study were to study the significance of the sense of coherence in the formation of mindfulness and the levels of development of its components in individuals with different levels of health.Materials and Methods. To study the peculiarities of the manifestation of a sense of coherence and the levels of development of its components, a survey was conducted in face-to-face and electronic forms and the questionnaire "Sense of coherence" was applied among respondents with health disorders and from a conditionally healthy group.Results. Analysis of the research results showed that the level of a sense of coherence has connections with the type and degree of health disorders, the period of their appearance and the person's age, but does not have a pronounced relationship with gender. People with physical and somatic health disorders have more developed cognitive functions such as comprehensibility and meaningfulness. Individuals with emotional and mental disorders have a higher level of controllability. In persons from the conditionally healthy group, the feeling of coherence is expressed in a moderate degree; they have a higher level of comprehensibility and controllability, and their meaningfulness is reduced.Discussion and Conclusion. The obtained information on the levels of development of a sense of coherence in persons with health disorders and from a conditionally healthy group allows us to compare the development of their cognitive perception and the possibilities of cognition of the world around them. The research results can be used in psychological support and pedagogical work with persons with health disorders, including disabilities and disabilities.
DETERMINAN YANG BERHUBUNGAN DENGAN TINDAKAN SADARI PADA MAHASISWI DI FAKULTAS KESEHATAN MASYARAKAT UNIVERSITAS MULAWARMAN
Authors: Rozkiah Hilda Marfu'ah , Gunawan Ike Anggraeni , Nurrachmawati Annisa 
Published: November 2021

ABSTRACT
World Health Organization (WHO) estimates that 8 until 9 percent women suffering from breast cancer and 84 million people died from cancer between 2005-2015. The high incidence and fatality rate of cancer could be minimized with prevention especially implemented by adolescents with health educational backgrounds. This study aims to determine association between knowledge, attitude, information exposure and health workers support with breast self-examination (BSE) as an early detection of breast cancer in students at the Faculty of Public Health, Mulawarman University. This was an observational study with cross-sectional approach. The subjects were 114 female students chosen by purposive sampling. Data collected by online questionnaire and analyzed using chi-square test. The study showed that there were significant association between information exposure with BSE (p value
KAJIAN ERGONOMI SARANA PENDUKUNG PROSES BELAJAR TERHADAP KELUHAN GOTRAK MAHASISWA INSTITUSI PENDIDIKAN X
Authors: Aryadi Valyaty Frisa , Susilowati Indri Hapsari 
Published: November 2021

ABSTRACT
Quality of learning is determined by a classroom, where a classroom must have facilities to support the learning process, at least chairs, tables, blackboards, and LCD projectors. The design of supporting facilities for the learning process that is not following ergonomic principles can cause the risk of muscle and skeletal disorders. This study aims to examine and provide an overview related to ergonomic support facilities for the learning process contained in the classrooms of Educational Institution X. the learning process is not following the principles of ergonomics and causes complaints of skeletal muscle disorders in students. Complaints of muscle disorders felt by 97.61% of students in their body parts and related to choices when they study in the classroom, it is necessary to take corrective steps by redesigning to support the existing learning process and for students to have a comfortable seat so as not to display skeletal muscle disorders.

Key word: ergonomic, study posture, MSDs

ABSTRAK
Kualitas pembelajaran yang baik dipengaruhi oleh karakteristik ruang kelas, dimana dalam sebuah ruang kelas harus memiliki sarana pendukung proses belajar minimal kursi, meja, papan tulis, dan LCD pyoyektor. Perancangan desain sarana pendukung proses belajar yang tidak sesuai prinsip ergonomi dapat menyebabkan risiko gangguan otot dan tulang rangka Penelitian ini bertujuan untuk mengkaji dan memberi gambaran terkait ergonomic sarana pendukung proses belajar yang terdapat pada ruang kelas Institusi Pendidikan X. Berdasarkan hasil penelitian diketahui bahwa desain sarana pendukung proses belajar tidak sesuai dengan prinsip ergonomi dan menyebabkan keluhan gangguan otot rangka pada mahasiswa. Keluhan gangguan otot rangka dirasakan oleh 97,61% mahasiswa pada bagian-bagian tubuhnya dan berhubungan bermakna dengan postur janggal pada saat mereka belajar di ruang kelas diperlukan adanya langkah perbaikan dengan mendesain ulang sarana pendukung proses belajar yang ada dan atau menyerukan kepada mahasiswa agar memilih tempat duduk yang nyaman agar tidak mengeluhkan gangguan otot rangka.

Kata kunci: ergonomi, postur belajar, gotrak
FAKTOR – FAKTOR YANG MEMPENGARUHI PASIEN FRAKTUR MEMILIH PENGOBATAN TRADISIONAL
Authors: Keytimu Yosephina Maria Hawa 
Published: November 2021

Pendahuluan: Pemilihan pengobatan tradisional masih menjadi salah satu pilihan dalam pengobatan masyarakat di Indonesia. Pelayanan kesehatan tradisional yang cukup populer di masyarakat Indonesia adalah pengobatan fraktur atau sering disebut masyarakat sebagai dukun patah tulang. Pengobatan tradisional masih digunakan oleh sebagian besar masyarakat bukan hanya karena kekurangan fasilitas pelayanan kesehatan formal yang terjangkau, melainkan lebih disebabkan oleh banyak faktor. Tujuan dari Penelitian ini adalah untuk menganalisis faktor-faktor yang mempengaruhi pasien fraktur memilih pengobatan tradisional. Metode: Jenis Penelitian ini adalah Penelitian kuantitatif dengan desain crossectional. Populasi dalam Penelitian ini adalah semua pasien fraktur yang menolak tindakan medis dan memilih untuk berobat ke pengobatan tradisional/dukun patah tulang dengan jumlah sampel 30 orang, yang diperoleh dari total sampling. Data yang digunakan adalah data primer yang diambil dengan menggunakan kuesioner yang dilaksanakan pada bulan Juni-Juli 2021. Analisa data yang digunakan adalah analisa univariat, analisa bivariat dengan menggunakan uji chi square dengan tingkat kemagnaan 75% (α<0,25) dan analisa multivariate dengan uji regresi logistik. Hasil: Hasil Penelitian berdasarkan uji chi square didapatkan nilai variable pendidikan p value 0,01, pengetahuan 0,341, ekonomi 0,126 dan dukungan keluarga 0,850. Hasil analisa multivariate dengan uji regresi logistic didapatkan nilai signifikan pendidikan 0.996>0,25 dan 0,997>0,25 untuk ekonomi. Kesimpulan: dari hasil Penelitian disimpulkan bahwa tidak ada pengaruh pendidikan, pengetahuan, ekonomi dan dukungan keluarga terhadap pemilihan pengobatan tradisional fraktur.