bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLC39A5 dysfunction impairs extracellular matrix synthesis in high myopia pathogenesis
Authors: Dong Shanshan , Tian Qi , Zhu Tengfei , Wang Kangli , Lei Ganting , Liu Yanling , Xiong Haofeng , Shen Lu , Wang Meng , Zhao Rongjuan , Wu Huidan , Li Bin , Zhang Qiumeng , Yao Yujun , Guo Hui , Xia Kun , Xia Lu , Hu Zhengmao 
Published: July 2021

AbstractHigh myopia is one of the leading causes of visual impairment worldwide with high heritability. We have previously identified the genetic contribution of SLC39A5 to nonsyndromic high myopia and demonstrated that disease‐related mutations of SLC39A5 dysregulate the TGF‐β pathway. In this study, the mechanisms underlying SLC39A5 involvement in the pathogenesis of high myopia are determined. We observed the morphogenesis and migration abnormalities of the SLC39A5 knockout (KO) human embryonic kidney cells (HEK293) and found a significant injury of ECM constituents. RNA‐seq and qRT‐PCR revealed the transcription decrease in COL1A1, COL2A1, COL4A1, FN1 and LAMA1 in the KO cells. Further, we demonstrated that TGF‐β signalling, the regulator of ECM, was inhibited in SLC39A5 depletion situation, wherein the activation of receptor Smads (R‐Smads) via phosphorylation was greatly blocked. SLC39A5 re‐expression reversed the phenotype of TGF‐β signalling and ECM synthesis in the KO cells. The fact that TGF‐β signalling was zinc‐regulated and that SLC39A5 was identified as a zinc transporter urged us to check the involvement of intracellular zinc in TGF‐β signalling impairment. Finally, we determined that insufficient zinc chelation destabilized Smad proteins, which naturally inhibited TGF‐β signalling. Overall, the SLC39A5 depletion–induced zinc deficiency destabilized Smad proteins, which inhibited the TGF‐β signalling and downstream ECM synthesis, thus contributing to the pathogenesis of high myopia. This discovery provides a deep insight into myopic development.
Assessing trophic interactions between pelagic predatory fish by gut content and stable isotopes analysis around Fernando de Noronha Archipelago (Brazil), Equatorial West Atlantic
Authors: Martins Karla , Pelage Latifa , Justino Anne K. S. , Frédou Flavia Lucena , Júnior Teodoro Vaske , Le Loc'h François , Travassos Paulo 
Published: July 2021

AbstractThe objective of this study was to analyse the feeding habits and trophic interactions between four oceanic predatory fish around the Fernando de Noronha Archipelago (FNA), Brazil, in the western equatorial Atlantic (3.86°S/32.42°W), internationally recognized as an environment of high economic and ecological value. For this purpose, biological samples of yellowfin tuna (Thunnus albacares), wahoo (Acanthocybium solandri), barracuda (Sphyraena barracuda) and dolphinfish (Coryphaena hippurus) were collected for stomach content and stable isotope analysis. Values of the index of relative importance revealed varied diets, with a strong presence of teleost fishes (Diodontidae and Exocoetidae) for all species, with yellowfin tuna having a greater diversity of food items. Despite being generalists/opportunists, the feeding strategy of these predators showed a tendency towards a specialized diet in the use of the available resources around the FNA. They presented a narrow trophic niche width (Levin's index, Bi < 0.6) and low overlap between species, except between barracuda and wahoo (MacArthur and Levin's,R0 = 0.72). Isotopic compositions had broad values of δ13C and δ15N, and were significantly different between species. Our results provide information about the four species' trophic organization and suggest that the predators avoid competition by preying on different prey, thus allowing their coexistence.
Poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) with zinc oxide nanoparticles for food packaging
Authors: Díez‐Pascual Ana M. 
Published: July 2021

AbstractPoly(3‐hydroxybutyrate) (PHB) is a biodegradable biopolyester synthesized via bacterial fermentation from renewable resources that has received great attention over the last years for medicine and food packaging applications. However, it shows several shortcomings such as narrow processing window and a high crystallinity (>50%), which leads to brittleness and low impact resistance. To solve these drawbacks, the hydroxybutyrate units can be copolymerized with other monomers like 3‐hydroxyhexanoate to yield poly(3‐hydroxybutyrate‐co‐3‐hydroxy‐hexanoate) (PHBHHx), a copolymer with higher ductility, improved impact strength, and lower melting point. However, PHBHHx displays lower crystallinity than PHB, hence reduced stiffness, and poorer barrier properties against moisture and gases, which is a disadvantage for its use as food packaging material. In this regard, (PHBHHx)‐based bionanocomposites incorporating 0.5, 1.0, 2.0, and 5.0 wt% zinc oxide (ZnO) nanoparticles were synthesized via solution casting technique. Their morphology, mechanical, thermal, barrier, and antibacterial properties were investigated via transmission electron microscopy, tensile and impact strength tests, thermogravimetric analysis, water vapor, and oxygen permeability measurements as well as antibacterial tests. In terms of gas permeability, the optimum performance was attained at 5.0 wt% ZnO loading, with reductions in the water vapor and oxygen permeability of 45 and 33%, respectively. Conversely, the impact strength decreased with increasing ZnO concentration, leading to 25% reduction for the highest ZnO loading tested. The bionanocomposite with 5.0 wt% ZnO is a promising alternative to synthetic plastics, with an optimal balance of toughness, barrier, and antibacterial properties to be used in packaging and disposable applications such as beverage and food containers.Practical applicationsThis study analyzes the morphology, thermal, mechanical, barrier, and antibacterial properties of biodegradable nanocomposites based on PHBHHx copolymer and ZnO nanoparticles. These safe and environmentally friendly nanomaterials can be used as a sustainable alternative to synthetic plastics for food and beverage containers.
Divergent metamorphism within the Namche Barwa Complex, the Eastern Himalaya, Southeast Tibet, China: Insights from in situ U–Th–Pb dating of metamorphic monazite
Authors: Peng Tao , Gerdes Axel , Zeng Ling‐Sen , Millonig Leo J. , Albert Richard , Marko Linda , Wang Hao Y. C. , Wu Chun‐Ming 
Published: July 2021

AbstractGeothermobarometry shows that metapelite samples from Namche Barwa Complex (NBC) reached upper amphibolite to near‐granulite facies during the peak metamorphic stage, with similar conditions of ~700–750°C/8–10 kbar, and then experienced retrograde metamorphism at ~630–700°C/4–7 kbar. In situ monazite laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS) U–Th–Pb dating suggests divergent metamorphism in the NBC: metapelite on the hanging wall of Namu–La thrust preserved a continuous metamorphic record of >19–3 Ma, whereas metapelite on the footwall yielded age ranges of >18–14 and 8–3 Ma, with a gap in recorded ages between 14 and 8 Ma. Monazite grains in the garnet porphyroblasts, more depleted in the heavy rare earth elements (HREE), yielded the youngest age of ~14 Ma. This is interpreted as the timing of upper amphibolite facies peak metamorphism in the metapelite from the NBC, with the NBC being exhumed coherently thereafter. Furthermore, the discrepancy between reported peak metamorphic ages of high‐pressure granulite (~40–30 Ma, ~25–20 Ma) and mid‐pressure metapelite (~14 Ma, this study) indicate asynchronous subduction–exhumation processes in the NBC. We suggest that crustal flow has played an essential role in exhumation since ~40 Ma, and recent surficial erosion (<8 Ma) intensified the exhumation of the NBC, with young leucogranite (<10 Ma) resulting from decompression melting. From ~3 Ma to the present, the interplay of erosion and tectonic movement caused ubiquitous rapid uplift, resulting in the concomitant exhumation of various types of rocks and the formation of the spectacular high relief between Yarlung Tsangpo Gorge and Namche Barwa Peak.
Scaling of axial muscle architecture in juvenile Alligator mississippiensis reveals an enhanced performance capacity of accessory breathing mechanisms
Authors: Rose Kayleigh A. R. , Tickle Peter G. , Elsey Ruth M. , Sellers William I. , Crossley Dane A. , Codd Jonathan R. 
Published: July 2021

AbstractQuantitative functional anatomy of amniote thoracic and abdominal regions is crucial to understanding constraints on and adaptations for facilitating simultaneous breathing and locomotion. Crocodilians have diverse locomotor modes and variable breathing mechanics facilitated by basal and derived (accessory) muscles. However, the inherent flexibility of these systems is not well studied, and the functional specialisation of the crocodilian trunk is yet to be investigated. Increases in body size and trunk stiffness would be expected to cause a disproportionate increase in muscle force demands and therefore constrain the basal costal aspiration mechanism, necessitating changes in respiratory mechanics. Here, we describe the anatomy of the trunk muscles, their properties that determine muscle performance (mass, length and physiological cross‐sectional area [PCSA]) and investigate their scaling in juvenile Alligator mississippiensis spanning an order of magnitude in body mass (359 g–5.5 kg). Comparatively, the expiratory muscles (transversus abdominis, rectus abdominis, iliocostalis), which compress the trunk, have greater relative PCSA being specialised for greater force‐generating capacity, while the inspiratory muscles (diaphragmaticus, truncocaudalis ischiotruncus, ischiopubis), which create negative internal pressure, have greater relative fascicle lengths, being adapted for greater working range and contraction velocity. Fascicle lengths of the accessory diaphragmaticus scaled with positive allometry in the alligators examined, enhancing contractile capacity, in line with this muscle's ability to modulate both tidal volume and breathing frequency in response to energetic demand during terrestrial locomotion. The iliocostalis, an accessory expiratory muscle, also demonstrated positive allometry in fascicle lengths and mass. All accessory muscles of the infrapubic abdominal wall demonstrated positive allometry in PCSA, which would enhance their force‐generating capacity. Conversely, the basal tetrapod expiratory pump (transversus abdominis) scaled isometrically, which may indicate a decreased reliance on this muscle with ontogeny. Collectively, these findings would support existing anecdotal evidence that crocodilians shift their breathing mechanics as they increase in size. Furthermore, the functional specialisation of the diaphragmaticus and compliance of the body wall in the lumbar region against which it works may contribute to low‐cost breathing in crocodilians.
Evaluation of the effectiveness of delirium prevention care protocol for the patients with hip fracture: A randomised controlled study
Authors: Unal Nursemin , Guvenc Gulten , Naharci Mehmet 
Published: July 2021

AbstractAims and objectivesThis study aimed to investigate the effectiveness of a delirium prevention care protocol on pain, functional status, sleep quality and delirium prevention in patients with hip fractures.BackgroundThe development of delirium following hip fracture is common among older patients. According to the National Institute for Health and Care Excellence, 30% of delirium cases are preventable. The prevention of delirium, a multifactorial syndrome, can be achieved through a multicomponent care protocol that targets specific risk factors for delirium.DesignA randomised controlled study was conducted according to the CONSORT 2010 guidelines. The Clinical Trial Registry number is NCT04188795.MethodsA total of 84 patients were assigned to two groups by block randomisation. The intervention group (n = 41) received nursing care according to a protocol and the control group (n = 43) received standard nursing care. Study data were collected using the demographic information form, the Confusion Assessment Method‐Intensive Care Unit (CAM‐ICU), the Barthel Index, the Mini Nutritional Assessment–short form and the Richards–Campbell Sleep Questionnaire (RCSQ). The pain of the patients was assessed by using a Visual Analog Scale (VAS).ResultsThe mean age of the patients was 80.6 years (standard deviation 8.0; range 65.0– 97.5 years), and the percentage of the male patients were 36.3%. No statistically significant differences were found between the groups in terms of pain and functional status in the preoperative period, on the first postoperative day, or in the predischarge period (p > 0.05 for each). The sleep quality of patients in the intervention group was significantly better than in the control group for all three time measurements (p < 0.05 for each). While 15% of patients in the control group developed delirium, no patient in the intervention group developed delirium (x2=6.486, p = 0.026).ConclusionThis study demonstrated that a delirium prevention care protocol may reduce the incidence of delirium and improve sleep quality.Relevance to practiceThe study highlighted that nurses can contribute to preventing patients’ delirium using nonpharmacologic and independent nursing interventions.
Economic integration among mainland Chinese immigrants during and after the period of Hong Kong's handover: The disparity between higher‐educated and lower‐educated groups
Authors: Tong Yuying , Chen Dan , Su Wenyang , Jiang Niantao 
Published: July 2021

AbstractWe examined mainland Chinese immigrants’ economic integration by looking at the earnings gap between locals and immigrants (both permanent and newly arrived) during and after the period of the Hong Kong handover from 1991 to 2016. During this period, Hong Kong experienced a further process of deindustrialization and an increased connection with mainland China. Using 5% Hong Kong population census/by‐census data (1991‐2016), we found that although mainland Chinese immigrants with college or above education still earned less than their local counterparts throughout the years, the income gap rapidly narrowed and their income levels converged in the more recent period. Meanwhile, the gap for those with high school degrees or below only slightly narrowed over time. Moreover, for those with high school degrees or below, the income gap between the permanent immigrants and the newly arrived ones remained constant over time, while a converging trend was observed among those with college or above degrees. Our findings suggest that immigrant economic integration may be accelerated when the socioeconomic linkage is closer between the origins and destination of migration, although some groups may benefit more than others.
The effects of mushroom powder and vitamin D2‐enriched mushroom powder supplementation on the growth performance and health of newly weaned pigs
Authors: Conway Eadaoin , Sweeney Torres , Dowley Alison , Maher Shane , Rajauria Gaurav , Yadav Supriya , Wilson Jude , Gabrielli William , O’Doherty John V. 
Published: July 2021

AbstractA complete randomised block design experiment was conducted to examine the effects of mushroom powder (MP) and vitamin D2‐enriched mushroom powder (MPD2) on growth performance, faecal scores, coefficient of apparent total tract digestibility (CATTD) of nutrients and selected microflora in weaned pigs up to day 35 post‐weaning. One hundred and ninety‐two weaned pigs (7.8kg [SD 1.08kg]) were blocked according to live weight, sex and litter of origin and randomly assigned to the following: (T1) control diet; (T2) control diet +MP; (T3) control diet + MPD2; and (T4) control diet +zinc oxide (ZnO) (n = 12 replicates/treatment). Mushroom powders were included at 2 g/kg of feed achieving a β‐glucan content of 200ppm. ZnO was included at 3100 mg/kg feed and halved to 1550 mg/kg after 21 days. Vitamin D content was enhanced in MPD2 using synthetic UVB exposure to obtain a vitamin D2 level of 100 µg/kg of feed. Faecal samples were collected on day 14 for microbial and nutrient digestibility analysis. There was no difference (p > 0.05) in ADG, G:F, faecal scores, microbial populations and CATTD of nutrients in pigs supplemented with MP or MPD2 compared with the control diet. The supplementation of MP and MPD2 caused a reduction (p < 0.05) in feed intake compared with the control and ZnO diet throughout the 35‐day experimental period. ZnO supplementation increased ADG and ADFI (p < 0.05) during the first period (D0‐21) compared with pigs offered MP and MPD2. In conclusion, MP and MPD2 supplementation resulted in similar ADG, G:F, faecal scores compared with the control but were not comparable to ZnO, mainly due to a reduction in feed intake.
Gender‐Based Perspectives on Professional Healthcare Chaplaincy Board Certification
Authors: White Kelsey B. , Combs Ryan M. , Decker Hallie R. , Schmidt Brandon M. 
Published: July 2021

AbstractThis article explores the ways in which gendered processes play out through the professionalization of chaplains in healthcare settings. It describes how gender manifests within organizations, how literature addresses the role of gender in professionalization, and considerations for professional chaplaincy. Fifty interviews with U.S. chaplains were analyzed to explore the relationship between the professionalization of chaplaincy and male and female positionality. Although gender theory moves beyond binary conceptualizations of gender, all participants in this study self‐identified as male or female and our data were analyzed accordingly. The language and professionalization efforts used by male and female chaplains mirror the gendered cultural expectations associated with these groups. This article notes how the patriarchal structures of both religious and healthcare institutions are inextricably embedded in the chaplaincy profession; thus, female chaplains have found it necessary to challenge these systems from the beginning.
Measuring Educational Neuromyths: Lessons for Future Research
Authors: Sullivan Karen A. , Hughes Brenda , Gilmore Linda 
Published: July 2021

ABSTRACTEducational neuromyths are incorrect ideas about the brain and learning. These ideas pose a risk if they impact learner outcomes. The concern about neuromyths has spurred global research, including teacher surveys about their identification. If such research leads to corrective strategies, the potential beneficiaries are teachers, students, and the field of educational neuroscience itself. This research relies on accurate neuromyth measures, and yet the topic of measurement has been largely ignored. In this review, we focus on key measurement issues surrounding the assessment of neuromyths, and we consider measurement improvements. We show that the framing of items, both the fact and neuromyth, must be improved in future research. These changes are vital to realize the potential benefit of educational neuromyth research.
Coping with chronic cardiovascular disease in Iran: A qualitative study
Authors: Kalantarzadeh Mozhgan , Alavi Mousa , Yousefi Hojatollah , Maghsoudi Jahangir , Hungerford Catherine , Cleary Michelle 
Published: July 2021

AbstractThe effects of chronic cardiovascular disease can challenge the achievement of treatment goals and recovery outcomes. This study explores the ways in which patients cope with the effects of chronic cardiovascular disease, from the perspectives of patients, family caregivers, and health professionals. The qualitative study was conducted from May 2019 to September 2020 in Isfahan, Iran. Thirteen people with chronic cardiovascular disease, 6 family caregivers, and 16 healthcare professionals participated in semi‐structured individual interviews. Transcripts were analysed thematically. Findings suggest that people with chronic cardiovascular disease use a range of coping strategies, both positive and negative, to adjust to their conditions. The positive strategies include managing their health‐related symptoms, drawing on religious or spiritual beliefs, and accessing social and relational supports. Negative strategies can include over‐reliance on family members for support, leading to reduced activity and loss of independence. Understanding the nature of the strategies used by patients provides an important means by which health service providers can support patients to further develop positive coping strategies. This, in turn, will enable patients to achieve higher levels of wellbeing.
Successful allogeneic stem cell transplantation with fludarabine‐based reduced intensity conditioning in bone marrow failure syndrome 4
Authors: Barhoom Dima , Mohseni Rashin , Behfar Maryam , Hamidieh Amir Ali 
Published: July 2021

AbstractBackgroundMyb‐like, SWIRM, and MPN domains 1 (MYSM1) is a histone H2A deubiquitinase, has been discovered as one of the transcriptional regulators, and regulates the expression of specific transcription factors, which are essential for immunohematology development. Mutation in MYSM1 in humans leads to a rare autosomal recessive disease that has recently been known as inherited bone marrow failure syndrome 4 (BMFS4) associated with congenital bone marrow failure, immunodeficiency, and developmental aberrations. Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative option for immunohematology defects.MethodsIn this paper, we report a pediatric patient with BMFS4 who suffered from pancytopenia and immunodeficiency affecting B cells and was successfully treated with HSCT from an HLA‐identical father at 6 years old of age. Fludarabine‐based reduced intensity conditioning was used and resulted in full donor chimerism.ResultsAcute graft versus host disease (GVHD) grade II involving skin and gastrointestinal tract was observed, which was controlled with prednisolone.ConclusionShe achieved B‐cell recovery, and no blood or platelet transfusion was reported 1 year after HSCT.
Loneliness may mediate the relationship between depression and the quality of life among elderly with mild cognitive impairment
Authors: Zafar Jawairia , Malik Najma Iqbal , Atta Mohsin , Makhdoom Irsa Fatima , Ullah Irfan , Manzar Md. Dilshad 
Published: July 2021

BackgroundDepression and mild cognitive impairment (MCI) are often comorbid mental health issues in older adults. The current study explored the prospective mediating role of loneliness in the relationship between depression and the quality of life in elderly with MCI. A second aim was to examine differences in depression, loneliness, and the quality of life in the elderly with MCI among gender groups, and type of residence groups.MethodsA cross‐sectional survey with purposive sampling was used. Older adults with MCI (N = 170) from old age homes in Lahore and Rawalpindi (n = 82) and family residences in Sargodha (n = 88) in Pakistan completed UCLA Loneliness Scale, Depression Anxiety Stress Scale, and Mild Cognitive Impairment Scale.ResultsMost of the participants had severe to extreme depression (98.2%), and moderate to moderately high levels of loneliness (85.3%). Depression was significantly associated with loneliness (b = 0.29, P < 0.05) and poor quality of life in MCI (b = 0.49, P < 0.001). The indirect effect of depression on the quality of life in MCI through loneliness was significant (95% confidence interval (CI) [0.002, 0.156]). However, the indirect effect of quality of life in MCI on depression through loneliness was not significant (95% CI [−0.001, 0.043]). The elderly with MCI living in old age homes had higher depression, loneliness, and poor quality of life. Elderly women had higher levels of depression and poor quality of life, whereas older men were lonelier.ConclusionThe relationship between depression and quality of life in the elderly with MCI may be bidirectional, and loneliness partially mediates only one of these relationships.