bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary insights into the effects of spinal manipulation therapy of different force magnitudes on blood biomarkers of oxidative stress and pro-resolution of inflammation mediators
Authors: Duarte Felipe C. K. , Funabashi Martha , Starmer David , Partata Wania A. 
Published: February 2025

Abstract

Background
Evidence has been reported that spinal manipulation therapy (SMT) leads to spine segmental hypoalgesia through neurophysiological and peripheral mechanisms related to regulating inflammatory biomarker function. However, these studies also showed substantial inter-individual variability in the biomarker responses. Such variability may be due to the incomplete understanding of the fundamental effects of force-based manipulations (e.g., patient-specific force-time characteristics) on a person’s physiology in health and disease. This study investigated the short-term effects of distinct SMT force-time characteristics on blood oxidative stress and pro-resolution of inflammation biomarkers.

Methods
Nineteen healthy adults between 18 and 45 years old were recruited between February and March 2020 before the COVID-19 pandemic and clustered into three groups: control (preload only), target total peak force of 400 N, and 800 N. A validated force-sensing table technology (FSTT®) determined the SMT force-time characteristics. Blood samples were collected at pre-intervention, immediately after SMT, and 20 min post-intervention. Parameters of the oxidant system (total oxidant status, lipid peroxidation and lipid hydroperoxide), the antioxidant system (total antioxidant capacity and bilirubin), and lipid-derived resolvin D1 were evaluated in plasma and erythrocytes through enzyme-linked immunosorbent assay and colorimetric assays.

Results
The COVID-19 global pandemic impacted recruitment, and our pre-established target sample size could not be reached. As a result, there was a small sample size, which decreased the robustness of the statistical analysis. Despite the limitations, we observed that 400 N seemed to decrease systemic total oxidant status and lipid peroxidation biomarkers. However, 800 N appeared to transitorily increase these pro-oxidant parameters with a further transitory reduction in plasma total antioxidant capacity and resolvin D1 mediator.

Conclusion
Despite the small sample size, which elevates the risk of type II error (false negatives), and the interruption of recruitment caused by the pandemic, our findings appeared to indicate that different single SMT force-time characteristics presented contrasting effects on the systemic redox signalling biomarkers and pro-resolution of inflammation mediators in healthy participants. The findings need to be confirmed by further research; however, they provide baseline information and guidance for future studies in a clinical population.
Multiple forms of discrimination and obsessive-compulsive disorder: a prospective cohort study
Authors: Nagata Jason M. , Talebloo Jonanne , Diep Thang , Shim Joan , Al-Shoaibi Abubakr A. A. , Ganson Kyle T. , Testa Alexander , He Jinbo , Lavender Jason M. , Baker Fiona C. 
Published: February 2025

Abstract

Background
Discrimination increases the risk for adverse mental health in minority populations, with studies showing elevated rates of obsessive-compulsive disorder (OCD) in Black adults facing racial discrimination. Yet, there is a lack of longitudinal research on the different forms of discrimination in relation to OCD risk in early adolescence. The objective of this study was to examine the prospective associations between multiple forms of discrimination and OCD in a national sample of U.S. early adolescents.

Methods
We examined prospective cohort data from Year 2 (2018–2020, ages 10–13) and Year 3 (2019–2021) of the Adolescent Brain Cognitive Development Study (N = 7,983). Multiple logistic regression models were used to analyze associations between Year 2 past 12-month experiences of discrimination (based on race and ethnicity, country of origin, sexual orientation, weight, and combined multi-discrimination) and Year 3 probable OCD (Child Behavior Checklist; based on dichotomized t-score indicating high risk), adjusting for theoretically relevant covariates including age, sex, sexual orientation, race and ethnicity, country of origin, household income, parent education, depression, body mass index category, study site, and Year 2 probable OCD.

Results
Adjusting for all covariates, multi-discrimination (OR = 1.67; 95% CI 1.23, 2.27), racial discrimination (OR = 2.77; 95% CI 1.32, 5.80), sexual orientation discrimination (OR = 2.51; 95% CI 1.11, 5.64), and weight discrimination (OR = 2.51; 95% CI 1.13, 5.59) at Year 2 were prospectively associated with developing probable OCD at Year 3. There were no significant findings for discrimination based on country of origin.

Conclusions
Early adolescents who have experienced several forms of discrimination have higher odds of developing probable OCD, suggesting the utility of screening for OCD in even younger adolescents who have encountered discrimination. Educators can play a role in guiding adolescents experiencing discrimination to appropriate resources for accessing mental healthcare.
Highlighting recent achievements to advance more effective cancer immunotherapy
Authors: Belmonte Beatrice , Spada Sheila , Allavena Paola , Benelli Matteo , Bronte Vincenzo , Casorati Giulia , D’Ambrosio Lorenzo , Ferrara Roberto , Mondino Anna , Nisticò Paola , Sommaggio Roberta , Tazzari Marcella , Tripodo Claudio , Sica Antonio , Ferrucci Pier Francesco 
Published: February 2025

Abstract
From 17 to 19th October 2024, the XXI Italian Network for Bio-Immunotherapy of Tumors Meeting (NIBIT) took place in Palermo, in the marvelous historical location of Teatro Politeama, under the auspices of the Italian Association of Medical Oncology (AIOM), Italian Association of Cancer Research (AIRC), Fondazione Pezcoller, Italian Alliance against Cancer (ACC), Italian Lymphoma Foundation (FIL), Grazia Focacci Foundation and Melagioco Foundation. The conference covered a spectrum of topics ranging from target discovery to therapeutic advances in immuno-oncology, bringing world-renowned experts to present groundbreaking innovations in basic, translational, and clinical cancer research. Six sessions focused on cellular therapies, digital pathology, vaccines, tertiary lymphoid structures, and microenvironment in order to get deep insights on how to personalize diagnosis and therapies in the clinical setting. Young investigators had the opportunity to meet and greet their mentors, promoting the synergy of the academic and industrial sectors within the national and international panorama, discussing the application of artificial intelligence on multi-specific antibodies, drug conjugates, and antibody fusion proteins that are advancing the efficacy of precision medicine and minimizing off-target effects.
Application of fatty acid-based eutectic mixture as a phase change material in microencapsulation of drugs: preparation, characterization and release behavior
Authors: Ghaffari Fariba , Shekaari Hemayat 
Published: February 2025

Abstract
Recently, microencapsulation has developed in various industries with its versatile applications. Its profound impact is particularly notable in the chemical, food, and pharmaceutical sectors. Among its research areas, the microencapsulation of drugs using phase change materials (PCMs) stands out as a groundbreaking advancement in drug delivery systems. This innovative approach involves encasing drugs within a PCM shell, significantly enhancing their stability and delivery regulation. The focus of our study is the microencapsulation of certain drugs with poor water solubility namely, cyclosporine, baclofen, and biotin within a bio-based PCM. It has identified PCMs with phase transition temperatures near human body temperature ( 310 K) as ideal candidates for this purpose. A eutectic mixture of stearic-lauric acid in a 1:3 mole ratio was selected for its optimal phase change properties to create microcapsules with core–shell morphology in spherical form. Our comprehensive characterization of the microcapsules, validated by FT-IR and SEM techniques, confirms their proper formation. All studied drugs microencapsulated with the PCM exhibited an excellent thermal stability at working temperature from thermal stability analysis based on TGA results. Furthermore, differential scanning calorimetry (DSC) tests conducted on the microencapsulated drugs obtained the melting point of all three microencapsulated drugs near the melting point of PCM. Also, the release behavior of drugs from drug delivery method was investigated in PBS (pH 7.4) and two temperatures (310.15 and 318.15) K. Drug release occurred sustainably, such that 50% and about 60% of the total of each drug was released from the microcapsules at mentioned temperatures respectively during 24 h.
The influence of constellation virtual community atmosphere on blogger trust and constellation infatuation behavior
Authors: Li Qingxia , Li Shuang , Li Qiang , Li Yingji 
Published: February 2025

Abstract
With the rapid development of social media, astrology-related virtual communities have gained significant popularity in China. However, the mechanisms behind the formation of astrological addiction behaviors within virtual communities remain largely unexplored. This study, based on the Stimulus-Organism-Response (S-O-R) theory, investigates how community environmental characteristics and user traits influence astrological addiction through the mediation of blogger trust. The results show that both community atmosphere (CA) and community expertise (PK) significantly influence constellation infatuation (CI) through the mediation of blogger trust (BT). Specifically, community atmosphere and community expertise positively affect constellation infatuation through blogger trust, supporting the proposed hypotheses. However, online participation (NI) does not have a significant indirect effect on constellation infatuation via blogger trust. The findings suggest that blogger trust plays a critical role in shaping astrological addiction behaviors within virtual communities. This study offers theoretical insights into community management and contributes to understanding the dynamics of addictive behaviors in online environments.
Sepsis-induced cardiac dysfunction: mitochondria and energy metabolism
Authors: Yu Xueting , Gao Jie , Zhang Chunxiang 
Published: February 2025

Abstract
Sepsis is a life-threatening multi-organ dysfunction syndrome caused by dysregulated host response to infection, posing a significant global healthcare challenge. Sepsis-induced myocardial dysfunction (SIMD) is a common complication of sepsis, significantly increasing mortality due to its high energy demands and low compensatory reserves. The substantial mitochondrial damage rather than cell apoptosis in SIMD suggests disrupted cardiac energy metabolism as a crucial pathophysiological mechanism. Therefore, we systematically reviewed the mechanisms underlying energy metabolism dysfunction in SIMD, including alterations in myocardial cell energy metabolism substrates, excitation–contraction coupling processes, mitochondrial dysfunction, and mitochondrial autophagy and biogenesis, summarizing potential therapeutic targets within them.
A summer in the greater Paris: trophic status of peri-urban lakes shapes prokaryotic community structure and functional potential
Authors: Foucault Pierre , Halary Sébastien , Duval Charlotte , Goto Midoli , Marie Benjamin , Hamlaoui Sahima , Jardillier Ludwig , Lamy Dominique , Lance Emilie , Raimbault Emmanuelle , Allouti Fayçal , Troussellier Marc , Bernard Cécile , Leloup Julie , Duperron Sébastien 
Published: February 2025

Abstract
With more than 12 million inhabitants, the Greater Paris offers a “natural laboratory” to explore the effects of eutrophication on freshwater lake’s microbiomes within a relative restricted area (~ 70 km radius). Here, a 4-months survey was carried out during summertime to monitor planktonic microbial communities of nine lakes located around Paris (Île-de-France, France) of comparable morphologies, yet distinct trophic statuses from mesotrophic to hypereutrophic. By thus minimizing the confounding factors, we investigated how trophic status could influence prokaryotic community structures (16S rRNA gene sequencing) and functions (shotgun metagenomics). These freshwater lakes harbored highly distinct and diverse prokaryotic communities, and their trophic status appears as the main driver explaining both differences in community structure and functional potential. Although their gene pool was quite stable and shared among lakes, taxonomical and functional changes were correlated. According to trophic status, differences in phosphorus metabolism-related genes were highlighted among the relevant functions involved in the biogeochemical cycles. Overall, hypereutrophic lakes microbiomes displayed the highest contrast and heterogeneity over time, suggesting a specific microbial regime shift compared to eutrophic and mesotrophic lakes.
Migration aspirations and their realisation: a configurational driver analysis of 26 African and Asian research areas
Authors: Czaika Mathias , Weisner Zina 
Published: February 2025

Abstract
‘Tackling the root causes’ of migration has emerged as a central strategy for the European Union to manage the movements of people from middle- or low-income countries. While the effectiveness of this approach remains a subject of debate, the field of migration studies has highlighted the interplay of multiple migration drivers, or driver complexes, rather than singled out'root causes'. However, empirical research has yet to assess the specific configurations and interactions of these driver complexes across diverse emigration contexts, and also, whether policy interventions have any impact in reducing migration aspirations and actual emigration. This paper employs Qualitative Comparative Analysis (QCA) to assess the complexities surrounding migration aspirations and realizations in 26 research areas spanning ten African and Asian countries. Following the two-step model of migration, the study identifies necessary and sufficient conditions explaining regional disparities in emigration aspirations and intensity. The analysis explores how structural hardships such as poverty, poor livelihoods, insecurity, conflict, weak governance, and environmental stress interact with socio-cultural factors such as transnational ties and cultures of migration. We find that such hardships alone are not necessary or sufficient for driving migration aspirations or actual out-migration. Migration aspirations are influenced by a complex interplay of socio-cultural and political-economic factors. Within this dynamic, both migration networks and international ties as well as the relative absence of migration-discouraging policies play central roles. At the same time, even a deeply rooted culture of migration and strong migration aspirations are per se not sufficient in generating high levels of out-migration.
Caliper verification and gap measurements of kinematic alignment total knee arthroplasty utilizing an imageless, accelerometer-based navigation system
Authors: Sikes James H. , Melancon Drew P. , Spears Isaac J. , Powers Evan H. , Montgomery Spencer J. 
Published: February 2025

Abstract

Purpose
Kinematic alignment (KA) in total knee arthroplasty (TKA) aims to restore the patient’s knee to the prearthritic state. The purpose of this study was to investigate the accuracy of using an implant-agnostic, imageless, accelerometer-based navigation system to perform KA TKA on the basis of caliper verification and quantification of the flexion and extension gaps.

Materials and methods
Seven cadaveric lower extremities underwent primary TKA utilizing a kinematic alignment workflow with the imageless navigation system. Accuracy of the technique was confirmed through caliper verification of bone cuts.

Results
All cuts were within 1 mm of anticipated measurements, except for the lateral tibial fragment, which averaged 1 mm (standard deviation [SD] 0.9 mm) thicker than anticipated. In extension, medial and lateral gaps were symmetric and averaged within 0.6 mm of expectation. In flexion, the medial gap averaged within 0.5 mm of expectation, while the lateral gap averaged 2.6 mm larger than the symmetric expectation, consistently producing a trapezoidal space.

Conclusions
The implementation of an accelerometer-based navigation system in KA TKA allows for highly accurate results, which was confirmed with caliper verification. This workflow produced a symmetric extension gap and a trapezoidal flexion gap with an average increased lateral flexion gap of 2.6 mm compared with the medial side.
War for talent or even enemy at the gate? Investigating the role of employer brand experience in talent retention
Authors: Azimi Mohammad , Sadeghvaziri Faraz , Ebrahimi Elham , Mozafari Amin 
Published: February 2025

Abstract
Employer Branding is a crucial strategy for attracting and retaining talent within an organization. This concept has garnered significant attention from scholars and practitioners, resulting in various conceptualizations of employer branding elements. Despite this interest, the field remains relatively underdeveloped, and aspects such as employer brand experience require further exploration. This study contributes to the growing body of employer branding research by clarifying the role of employer brand experience and its relationship with concepts such as employer brand personality, employer brand identification, and talent retention. Data were collected from the Special Forces officers of the Iranian National Army and analyzed using the partial least squares method. The results indicate that employer brand experience and employer brand personality have a direct, significant impact on talent retention. However, while employer brand identification's effect on talent retention is positive, it was not found to be significant. The findings provide practical implications for organizations, suggesting they can better position their employer brand by focusing on employer brand experience and aligning their employer brand personality with talent management strategies.
Inhibition of TSH receptor expression by a cyclotriazadisulfonamide as a potential treatment of Graves’ Hyperthyroidism
Authors: Krieger Christine C , Neumann Susanne , Sui Xiangliang , Templin Jay Scott , Kapri Topprasad , Demillo Violeta G , Olsen Ryan K , Intasiri Amarawan , Gershengorn Marvin C , Bell Thomas W 
Published: February 2025

Abstract
Graves’ hyperthyroidism (GH) is a condition in which autoantibodies chronically activate the thyrotropin (thyroid-stimulating hormone) receptor (TSHR). TSHR is one of the few G protein-coupled receptors (GPCRs) predicted to have a signal peptide, making it a potential target for cyclotriazadisulfonamide (CADA) compounds. We sought to determine whether a small-molecule drug that selectively induces nascent protein degradation could decrease TSHR expression in vitro and in vivo at therapeutically relevant levels. We tested several CADA compounds for their ability to reduce TSHR surface expression in HEK 293 cells overexpressing human TSHR (HEK-TSHR cells) using flow cytometry. Inhibition of downstream cAMP production and thyroglobulin (Tg) secretion were measured in HEK-TSHR and human thyrocytes respectively. Follow-up studies in VGD040-treated BALB/c mice assessed plasma levels of free T4 in response to TSH stimulation. Among a number of CADA analogues, VGD040 decreased TSHR at the surface of HEK-TSHR cells. VGD040 was found to be selective towards TSHR compared to similar glycoprotein hormone receptors. In human thyrocytes, reduction of TSHR surface-expression by VGD040 decreased cAMP production and Tg secretion. Most importantly, VGD040 decreased TH secretion in mice without apparent toxicity at the effective dose studied. VGD040 is an important new lead with potential for developing safe drug treatments for GH.
Analgesic Efficacy of Repeated Daily Injections Versus Continuous Adductor Canal Block After Total Knee Arthroplasty: An Open-Label, Randomized Clinical Trial
Authors: Kim Hansol , Yoo Seokha , Kwon Seokmin , Kim Youngwon , Bae Jinyoung , Kim Yoon Jung , Cho Youn Joung , Kim Jin-Tae , Lim Young-Jin 
Published: February 2025

BACKGROUND:
Total knee arthroplasty is frequently associated with postoperative pain. Continuous adductor canal blocks are widely used for postoperative analgesia. However, the high dislocation rate of nerve block catheters often leads to ineffective pain control. This study aimed to compare the analgesic effectiveness of repeated daily injections of adductor canal block up to postoperative day (POD) 2 and continuous adductor canal block in patients who underwent total knee arthroplasty.

METHODS:
Seventy-six patients who underwent total knee arthroplasty under spinal anesthesia were randomized to receive repeated daily adductor canal blocks at the end of surgery and in the morning of POD1 and POD2 (n = 39) or continuous adductor canal block with a patient-controlled bolus (n = 37). All patients received perioperative multimodal analgesia. The primary outcome was the time-weighted average numeric rating scale pain score at rest, measured from the end of surgery to 14:00 on POD2. Pain scores over time were also compared using generalized estimating equations.

RESULTS:
There was no significant difference in the time-weighted average pain score at rest (from POD0 to POD2) between the repeated injection group (2.9 ± 1.9) and the continuous group (3.1 ± 2.1; mean difference 0.09, 95% confidence interval [CI], −0.81 to 0.99; P = .842). Repeated daily injections did not reduce pain at rest or pain during movement after adjusting for time. In the continuous group, the cumulative occurrence of nerve block catheter dislocation was 48.6% (18/37) on POD1 and 62.2% (23/37) on POD2, as assessed using ultrasonography.

CONCLUSIONS:
This study was unable to determine whether repeated daily injections or continuous adductor canal block provided superior analgesia in terms of the average pain score during the first 2 days after total knee arthroplasty. However, considering the high dislocation rate of nerve block catheters, reducing catheter dislodgement may improve the analgesic effectiveness of continuous adductor canal blocks.