bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferulic Acid – A Versatile Molecule
Authors: Drăgan Maria , Tătărîngă Gabriela , Mircea Cornelia , Cioancă Oana , Dragostin Oana , Iacob Andreea Teodora , Profire Lenuţa , Stan Cătălina Daniela 
Published: April 2021

Abstract
The review summarizes the main roles of ferulic acid (4-hydroxy-3-methoxy-cinnamic acid), a phenolic compound widespread in the vegetable world, being present in cereals (rice, wheat, oats), coffee, tomatoes, nuts or corn, but also in a range of plants used in Traditional Chinese Medicine. It plays a vital role in ensuring cell wall rigidity and also in the formation of other important organic compounds for plants. Ferulic acid has a wide variety of biological activities such as: antioxidant, anti-inflammatory, antimicrobial, antiallergic, anticancer, antithrombotic, antiviral activities, vasodilator, hepatoprotective and metal chelation actions, enzymatic activity modulation, and wound healing activity. The most important action is the antioxidant one, being studies that demonstrate that ferulic acid acts synergistically with other antioxidants. Also, the antioxidant effect of ferulic acid is enhanced by skin exposure to ultraviolet light, making it a good ingredient for sunscreen cosmetics. It is one of the most powerful natural antioxidant that has the potential to neutralize free radicals, to slow down the aging process of the skin, to accelerate skin regeneration, to heal the skin wounds and also to preserve the health and beauty of the skin.
Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
Authors: Habala L. , Pašková L. , Bilková A. , Bilka F. , Oboňová B. , Valentová J. 
Published: April 2021

Abstract
Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against S. aureus (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes.
The effects of COVID-19 on the labour market
Authors: Kádár Beáta , Nagy Szeréna 
Published: April 2021

Abstract
COVID-19 is currently a pandemic of such a magnitude that it affects economy, labour market, society and all aspects of life. Many researchers are currently engaged in examining the issues, challenges and impacts caused by COVID-19. It causes changes of such nature and degree in the economy and labour market that have been unprecedented. In fact, as a result of the pandemic, the operation and composition of the economy and the structure of the labour market will change. The present study examines how Romanian respondents see the impact of COVID-19 on the labour market, employment and on the different sectors of the economy.
Effect of Replacing Maize Grain by Hybrid Rye Grain in the TMR on Performance of Mid-Lactating Dairy Cows
Authors: Rajtar Patrycja , Sady Marek , Górka Paweł , Kehoe Sylvia , Micek Piotr 
Published: April 2021

Abstract
Grain from traditional varieties of rye is not commonly used in dairy cattle nutrition. However, new hybrid varieties of rye currently available are characterized by some nutritional and agrotechnical benefits. This paper deals with the hypothesis that rye grain derived from a hybrid variety may be an alternative for maize grain in diets for dairy cattle. Sixteen lactating Polish Holstein- Friesian cows were divided into two groups according to their parity (8 primi- and 8 multiparous), stage of lactation (106 ± 30 days after calving) and milk yield (34 ± 4 kg/day). Cows were fed a total mixed ration (TMR) containing grass silage and whole crop maize silage and 29.2% of the concentrate (in dry matter). The latter contained approximately 48% (as fed) of either maize grain (M) or hybrid rye grain (HR) as a main source of cereal grain. Experimental diets were fed for 9 weeks. The use of HR as a substitute for M did not affect (P>0.05) dry matter intake and milk yield. There were no differences between treatments in the content of milk solids, amino acids, and fatty acid profile. However, substituting M by HR positively influenced composition of milk protein fractions by increasing the proportion of α-casein (37.0 vs 39.7%; P<0.01) and к-casein (6.5 vs 7.3%; P=0.02) as well as decreasing the proportion of β-casein (28.8 vs 27.8%; P=0.02) and sensory characteristics of the milk (body and texture, and taste; P<0.05). In turn, the composition of the diet did not affect the technological suitability for processing of milk fat (acid and peroxide number, melting and solidification temperature), rennet coagulation time, heat stability or titratable acidity. This study has shown that hybrid rye grain may be an alternative for maize grain in a TMR based on grass and whole maize silage for mid-lactation dairy cows. Further studies are needed with higher proportion of hybrid rye grain in TMR or with other roughages used in a basal diet to fully determine efficiency of hybrid rye grain use in diets for dairy cows.
Dynamic plasma biochemical profile changes of weaning piglets fed diets containing different levels of Bacillus spp. as a probiotic product
Authors: Lavinia Idriceanu , Mihaela Dumitru , Aurelia Lefter Nicoleta , Anca Gheorghe , Mihaela Habeanu 
Published: April 2021

Abstract
In this study, an experiment was conducted to investigate the effects of two levels of Bacillus subtilis ATCC 6051a (BS), respectively Bacillus licheniformis ATCC 21424 (BL) administered as direct-fed microbial DFM probiotic bacteria on plasma biochemical profile of weaning piglets fed diets. A total of 100 piglets, 30±3 day-old, with initial average body weight (BW) of 8.53±0.17 kg were randomly distributed to 5 homogeneous groups (C, E1-BS 1%, E2-BS 3%, E3-BL 1%, E4-BL 3%,), 2 replicates/group with 10 piglets/pens, for 16 days of biological trial. The doses used were: 1% low dose in a concentration of 1.6 x 109 CFU spores g-1 feed, and 3% high dose in a concentration of 4.8 x 109 CFU spores g-1 feed. Results showed that BS supplementation affected plasma concentration of GGT (P<0.017), TG (P<0.048) and Mg (P<0.0001). No effect (P>0.05) as diet*day interaction on plasma metabolic profile was observed. In conclusion, administration of Bacillus spp. maintains the concentration of blood plasma parameters within the physiological ranges, without affecting the piglet’s health status.
Classic sports massage vs. Chinese self-massage. Which one is more effective in warm-up?
Authors: Boguszewski Dariusz , Adamczyk Jakub Grzegorz , Hanc Aleksandra , Szymańska Agata , Chełchowska Sylwia , Białoszewski Dariusz 
Published: April 2021

Abstract

Study aim: Warm-up is an indispensable element of sports training. The aim of the study was to determine the effect of warm-up exercises with Swedish, classic sports massage and Chinese self-massage on functional limitations of the locomotive system.

Materials and methods: The study included 42 women and 13 men aged 19 to 22. They all performed the Functional Movement Screen (FMS) test, without a warm-up, and then (after a week) performed it again after either a standard warm-up with sports massage (Group 1) or a warm-up with Chinese self-massage (Group 2).

Results: Both groups obtained significantly higher results in the second measurement (FMS test), preceded by a standard warm-up with sports massage (Group 1, p = 0.003) and warm-up with Chinese self-massage (Group 2, p = 0.000). In Group 1, statistically significant differences were observed in the results of the exercises: hurdle step and push-ups. In Group 2, the difference was significant in the attempts to sit down deep, walk over the fence and pump.

Conclusion: There were no significant differences between the groups that used massage and self-massage. Both methods can improve movement functionality.
The Environment, A Bipartisan Issue?: Partisanship Polarization and Climate Change Policies in the United States
Authors: Dotto Valentina , Oakes Anne Richardson 
Published: April 2021

Abstract
Responding to climate change presents significant challenges on both international and domestic fronts. The current U.S. federal government disclaims a connection between climate change, and human activity, and embraces an environmental program that includes withdrawal from the Paris Climate Change Agreement at international level and retrenchment from regulation domestically. This Article comments on the rollback of Obama-era environmental regulations now taking place at federal level and locates these policies in the context of the domestic polarization and partisanship that now characterizes U.S. politics. It notes that environmental regulation divides the Republican and Democratic Parties but that the response of individual party members may be more nuanced, particularly amongst younger voters. The Article comments on state level initiatives to counteract the effects of climate change that have gathered bipartisan support but are now subject to partisan actions by the federal government designed to limit their effectiveness. The Article concludes with the observation that as the combination of an aging demographic and alignment with a declining fossil fuel industry shrinks the GOP traditional constituency, it is to be hoped that far-sighted politicians from both parties will embrace credibility on this issue as a key component of enhancing their own as well as the planet’s survival.
Property Tax Reform and Urban Housing Production and Consumption in Nigeria
Authors: Daniel Maren Mallo , Nkup Joseph Tanko , Wuyokwe Nenrot Gombwer 
Published: April 2021

Abstract
In the past decade, the Nigerian government has witnessed dwindling revenues owing to fluctuating oil prices. This has necessitated the search for alternative revenue sources. For the authorities in Jos, the administrative city of Plateau State in north-central Nigeria, taxes within housing production and consumption loop were thought to be the easiest catch. Accordingly, the authorities intensified the generation of land titling fee, capital gains tax, value added tax, land use charge, ground rent, development permits, probate fee, withholding tax among others. These efforts came with some implication for urban housing. The paper aims to provide an understanding of this and it employed a wide range of secondary data of quantitative and qualitative forms in pursuits of two objectives. The first objective examined how property taxes were administered and found that multiple agencies were involved in tax administration and, as a result, double taxation occurred in land titling, seeking of development permits and probate. Furthermore, sporadic land and property registration impeded the development of a cadastre, thereby allowing the government to arbitrarily and outrageously apply taxes, which tax payers tried to evade through informal house building and property transactions. The second objective analysed the impact of property taxation and found that taxes accounted for a high cost of new housing and residential rentals but also had the potentials of stimulating housing production and consumption. Recommendations that could help the government generate revenue from taxing properties while also incentivising housing production and consumption were offered.
The Analysis of Urban Planning Aspects and Development of Residential Real Estate in Tallinn, Estonia
Authors: Köse İstemi Alp , Kauškale Linda 
Published: April 2021

Abstract
At the present time, the world’s population is rapidly increasing, and the existing resources, which are limited, are being significantly consumed. Due to this fact, in order to use these resources more efficiently, the concept of planning day by day gains importance in the framework of sustainable development. Although Estonia is one of the countries that has the fewest number of people in Europe, owing to its economic reliability, high development level and worldwide awareness of the field of software, Estonia has become one of the less affected countries by the crisis. At the same time, Estonia is one of European countries that executes planning for long-term economic development. The aim of the research is to analyse the interrelation aspects between urban planning and residential real estate development on different levels in Tallinn, capital of Estonia, in the context of sustainable development. Analysis and synthesis, comparison, observation, and logical deduction methods are used within the research. According to the research conducted, the price ranges of real estate objects are closer to each other in the condition towards homogeneity in residential settlements which have similar residential and planning features. It can be recommended to build a contemporary system regarding interrelation of urban decisions and tendencies within development of the real estate market, which can help investors and other market participants in sustainable, efficient, and long-term decision making.
Evaluating housing in urban planning using TOPSIS technique: cities of Isfahan province
Authors: Izadi Maliheh , Vardanjani Mehdi Jafari , Varesi Hamidreza 
Published: April 2021

Abstract
The indices of housing serve as an important tool in planning for housing, in that they allow the parameters affecting housing to be recognised and any planning process to be facilitated. The purpose of the study is to investigate and to evaluate the housing situation in cities of Isfahan province. The study is applied and descriptive-analytic in terms of method. Thirty-nine indices were collected in the housing sector. Then the rate of prosperity and ranking of the cities were evaluated by TOPSIS method. Prosperity is defined here as an important index of housing that reflects the welfare of residents. The cities were then categorised into six levels of prosperity: Very important, Important, Partially important, Moderate, Poor and Very poor. The results from the study indicate an imbalance in the studied indices between the cities, and a clear disparity between the levels of prosperity in the cities, and the only city in the very prosperous group is Isfahan, with a rate of 0.813.
Chemical constituents of Algerian mandarin (Citrus reticulata) essential oil by GC-MS and FT-IR analysis
Authors: Boughendjioua Hicham , Mezedjeri Nour El Houda , Idjouadiene Ilhem 
Published: April 2021

Abstract
Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Citrus oils are a complex mixture of more than a hundred components of differing chemical natures. Qualitative and quantitative analysis by gas chromatography coupled with mass spectrometry (GCMS) of the Citrus reticulata essential oil collected from El Hadaïk, Skikda City (Algeria), identified 28 compounds representing a total of 99.41%. The essential oil is constituted mainly of: D-Limonene (85.10%), Sabinene (2.49%), Linalyl acetate (2.00%), Copaene (1.80%) et α-Pinene (1.75%) totaling approximately 93.14%. The essential oil was also analyzed by Fourier transform infrared spectroscopy analysis (FTIR). FTIR spectroscopy allowed us to identify 10 volatile compounds and indicated that the functional groups of the essential oils are C-H (Alkene), C-H (aromatic) and C=C. The obtained results have shown that the essential oil can be fully utilized for pharmacy, cosmetology and industry.
Different molecular targets, one purpose – treatment of depression
Authors: Burat Magdalena , Gibula-Tarlowska Ewa , Kedzierska Ewa 
Published: April 2021

Abstract
Although vast scientific progress has been made, the current pharmacotherapy of depression is still not fully effective. In adults, depressive disorders are among the most common diseases in industrialized countries, impact upon all aspects of family and working life and significantly disturb social functioning. Moreover, increasingly, they affect children and teenagers.
Depressive disorders have a complex etiology. This includes a number of mechanisms that are not yet fully understood. Therefore, the current review concentrates on bringing to the foreground the many molecular areas involved in occurrence of this disease. The work highlights the notion that depression has a complex pharmacology and inevitably requires the adoption of individual pharmacotherapy. This manuscript concentrates on currently used drugs drawn from diverse therapeutic groups and presents new promising targets for the treatment of depression. This is a particularly important issue due to the continuous lack of effective therapy and the constant search for new drugs and molecular targets for its treatment.
The impact of functional food on the prevention and treatment of respiratory diseases
Authors: Widelska Gabriela , Kasprzak-Drozd Kamila , Wojtunik-Kulesza Karolina , Krajewska Anna , Oniszczuk Anna 
Published: April 2021

Abstract
Globally, diseases of the lung are one of the main causes of death, and conventional therapies are often ineffective in dealing with this serious medical and sociological problem. Since ancient times, medicinal plants have been used in the treatment of respiratory tract diseases. Such plants show antitussive, muscle relaxing, bronchi dilation or cillary movement effects. Their usefulness has been confirmed by modern and current research. A medicinal plant that is also a functional food can open new areas in the prevention and treatment of respiratory tract diseases. In this review, information about the influence of functional food on preventing and treating asthma, chronic obstructive pulmonary disorder (COPD) and high-altitude sickness are presented.
Influence of ketotifen and conventional antiepileptic drugs on the exploratory and spontaneous locomotor activity in mice
Authors: Zakrocka Izabela , Swiader Katarzyna , Swiader Mariusz 
Published: April 2021

Abstract
Drug interactions are major problems in polytherapy, especially in epilepsy, and inappropriate drug selection may result in increased frequency of seizures.
In this study, the influence of histamine type 1 (H1) receptor antagonist ketotifen and four chosen antiepileptic drugs (AEDs) on mice activity was examined. We evaluated three parameters of locomotor activity in mice: horizontal total activity with total distance and vertical activity, as well as animal spontaneous activity. Experiments were divided into two 15-minutes studies. During the first 15 minutes, we examined exploratory activity in mice; in the second period, spontaneous activity was tested. In the experiment, Ketotifen or vehicle were administered once or for 7 days daily, whereas AEDs were given only once before test performance.
Our results show that ketotifen given alone once or for 7 days significantly increased exploratory locomotor activity in mice without affecting their spontaneous activity. However, in combination with AEDs, ketotifen given once or for 7 days differently affected spontaneous and locomotor activity in mice. Our study indicates that the combination of ketotifen with AEDs needs special attention in pharmacotherapy of epilepsy.
Antimicrobial efficacy of Colgate Plax Cool Mint® mouthwash – in vivo studies
Authors: Szymanska Jolanta , Olejnik Ewa , Biernasiuk Anna , Malm Anna 
Published: April 2021

Abstract
Hygienic procedures in oral cavity, both teeth brushing and using mouthwashes, have an influence on the composition and quantity of oral microflora. The aim of the work was to evaluate the impact of regular use of selected mouthwash on the titer of Lactobacillus and Streptococcus bacteria and Candida yeast-like fungi in the saliva.
The evaluation of the influence of Colgate Plax Cool Mint® mouthwash on the number of Lactobacillus and Streptococcus bacteria and Candida yeast-like fungi in the saliva was done. The research included 39 persons at the age of 17±3 months, out of whom 30 people constituted a study group using mouthwash and 9 people – a control group not using mouthwash. The persons from the study group used the mouthwash twice a day for 2–3 minutes for the period of 5 months. The material for the microbiological tests constituted 2 ml of saliva collected three times from the participants: at the beginning of the research – before the use of a mouthwash and respectively, after 2.5 and 5 months from the first test.
Colgate Plax Cool Mint®, the most frequently used by the youth in their daily oral hygiene and used in the present study mouthwash, showed effectiveness in reduction of Lactobacillus spp. and S. mutans bacteria, as well as C. albicans yeasts in the saliva of the studied persons, what is undoubtedly connected with inhibition of formation and prevention of oral plaque development.
Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts
Authors: Aissous Imen , Benrebai Mouad , Cacan Ercan , Caglar Berkel , Erenler Ramazan , Ameddah Souad , Benayache Samir , Benayache Fadila , Bensouici Chawki 
Published: April 2021

Abstract
The aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the n-BuOH extract of Centaurea maroccana (BECM). The total phenolic and flavonoid of the butanolic extract of the plant were assessed by using Folin-Ciocalteau and aluminium chloride colorimetric assays, respectively, and the quantitative estimation of total flavonoids and phenols revealed the richness of the extract in these compounds. Antioxidant activity was evaluated using standard lab colorimetric methods, while the anti-proliferative activity was evaluated using sulforhodamine B (SRB) assay against C6 (Rattus norvegicus brain glioma) and HT29 (Homo sapiens colorectal adenocarcinoma) cell lines. The n-butanolic extract of Centaurea maroccana showed a strong antioxidant activity through DPPH, ABTS•+, DMSO alkalin, Reducing power, β-Carotene-linoleic acid and CUPRAC assays. Furthermore, the anti-proliferative activity against C6 and HT29 of Centaurea maroccana exhibited a high effect by the decrease in viability of both cancer cell lines. Our results suggest a possible use of Centaurea maroccana as a source of natural antioxidant and chemo-preventive agents against cancer.
Molecular docking study of the acetylcholinesterase inhibition
Authors: Merzoug Amina , Boucherit Hanane , Khaled Rima , Chefiri Amel , Chikhi Abdelouahab , Bensegueni Abderrahmane 
Published: April 2021

Abstract
While Alzheimer disease is the most common form of dementia, acetylcholinesterase is an interesting therapeutic target for the development of new anti-Alzheimer’s disease drugs. In order to discover potential compounds inhibiting this protein target, a molecular docking study of a similar collection of 1-[[2,4-bis[(E)hydroxyiminomethyl] pyridin-1-ium-1-yl]methoxymethyl] pyridin-1-ium-4-carboxamide (HLO) inhibitor from ZINC database using FlexX program was realized. Before performing the molecular docking, FlexX was validated by Root mean square deviation test to determine the reproducibility of the docking program. The strategy undertaken in this study permitted us to propose products 4-[[2-[(Z)-N’-hydroxycarbamimidoyl]-4-pyridyl]methylamino] benzamide and N-[(E)-[1-(4-nitrophenyl)pyrrol-2-yl]methylene amino]isonicotinamide as potential new inhibitors of humane acetylcholinesterase. The two proposed products may act as strong anti-Alzheimer leads compounds.