bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Data-Driven Framework for Automated Detection of Aircraft-Generated Signals in Seismic Array Data Using Machine Learning
Authors: Zhang Xinxiang , Arrowsmith Stephen , Tsongas Sotirios , Hayward Chris , Meng Haoran , Ben-Zion Yehuda 
Published: November 2021

Abstract
Ground motions associated with aircraft overflights can cover a significant portion of the seismic data collected by shallowly emplaced seismometers, such as new nodal and Distributed Acoustic Sensing systems. This article describes the first published framework for automated detection of aircraft on single channel and multichannel seismic data. The seismic data are converted to spectrograms in a sliding time window and classified as aircraft or nonaircraft in each window using a deep convolutional neural network trained with analyst-labeled data. A majority voting scheme is used to convert the output from the sequence of sliding time windows onto a decision time sequence for each channel and to combine the binary classifications on the decision time sequences across multiple channels. Precision, recall, and F-score are used to quantify the detection performance of the algorithm on nodal data using fourfold time-series cross validation. By applying our framework to data from the Sage Brush Flats nodal array in Southern California, we provide a benchmark performance and demonstrate the advantage of using an array of sensors.
Heated Tobacco Products Impair Cell Viability, Osteoblastic Differentiation, and Bone Fracture-Healing
Authors: Nishino Kazuya , Tamai Koji , Orita Kumi , Hashimoto Yusuke , Nakamura Hiroaki 
Published: November 2021

Background:
The negative impact of cigarette smoking on bone union has been well documented. However, the impact of heated tobacco product (HTP) use on bone fracture-healing remains unclear. The present study investigated the effect of HTPs on preosteoblast viability, osteoblastic differentiation, and fracture-healing and compared the effects with those of conventional combustible cigarettes.

Methods:
Cigarette smoke extracts (CSEs) were generated from combustible cigarettes (cCSE) and HTPs (hCSE). CSE concentrations were standardized by assessing optical density. Preosteoblast (MC3T3-E1) cells were incubated with normal medium, cCSE, or hCSE. The cell viability was assessed via MTT assay. After osteoblastic differentiation of CSE-exposed cells, alkaline phosphatase (ALP) activity was assessed. To assess the in vivo effects of CSEs, a femoral midshaft osteotomy was performed in a rat model; thereafter, saline solution, cCSE, or hCSE was injected intraperitoneally, and bone union was assessed on the basis of micro-computed tomography (μCT) and biomechanical analysis 4 weeks later.

Results:
MC3T3-E1 cell viability was reduced in a time and concentration-dependent manner when treated with either cCSE or hCSE. ALP activity after osteoblastic differentiation of cCSE-treated cells was significantly lower than that of both untreated and hCSE-treated cells (mean and standard deviation, 452.4 ± 48.8 [untreated], 326.2 ± 26.2 [cCSE-treated], and 389.9 ± 26.6 [hCSE-treated] mol/L/min; p = 0.002). Moreover, the levels of osteoblastic differentiation in untreated and hCSE-treated cells differed significantly (p < 0.05). In vivo assessment of the femoral midshaft cortical region revealed that both cCSE and hCSE administration significantly decreased bone mineral content 4 weeks after surgery compared with levels observed in untreated animals (107.0 ± 11.9 [untreated], 94.5 ± 13.0 [cCSE-treated], and 89.0 ± 10.1 mg/cm3 [hCSE-treated]; p = 0.049). Additionally, cCSE and hCSE-exposed femora had significantly lower bone volumes than unexposed femora. Biomechanical analyses showed that both cCSE and hCSE administration significantly decreased femoral maximum load and elastic modulus (p = 0.015 and 0.019).

Conclusions:
HTP use impairs cell viability, osteoblastic differentiation, and bone fracture-healing at levels comparable with those associated with combustible cigarette use.

Clinical Relevance:
HTP use negatively affects bone fracture-healing to a degree similar to that of combustible cigarettes. Orthopaedic surgeons should recommend HTP smoking cessation to improve bone union.
The AOA: A Comprehensive House with Compassionate Leaders. Presidential Address to the AOA, June 15, 2020
Authors: Parsons Theodore W. 
Published: November 2021

Abstract:
The American Orthopaedic Association (AOA) is the world’s oldest orthopaedic association and it has been responsible for the founding of many prominent organizations as well as The Journal of Bone & Joint Surgery. While the AOA has traditionally focused on academic orthopaedic leadership, the time has come to expand our horizons and look to include all orthopaedic leaders from the wide variety of leadership roles in which they currently serve.
Orthopaedic surgeons who demonstrate compassionate leadership will find that they create stronger, more successful teams. Compassionate leadership is a skill that can be learned, and investing the energy to develop this skill will have a profound impact on our success as orthopaedic surgeons and leaders.
Well Test Analysis for a Well in a Constant Pressure Square
Authors: Kumar Anil , Ramey H. J. 
Published: November 2021

Abstract
Very little information exists for analyzing well tests wherein a part of the drainage boundary is under pressure support from water influx or fluid injection. An idealization is the behavior of a well in the center of a square whose outer boundary remains at constant pressure. A study of this system indicated important differences from the behavior of a well in a closed outer boundary square, the conventional system. At infinite shut in, the constant- pressure boundary case well will reach the initial pressure of the system, rather than a mean pressure resulting from depletion. But it is possible to compute the mean pressure in the constant-pressure case at any time during shut in. Interpretative graphs for analyzing drawdown and buildup pressures are presented and discussed. This case is also of interest in analysis of well tests obtained from developed five-spot fluid injection patterns.

Introduction
Well-test analysis has become a widely used tool for reservoir engineers in the last twenty years. The initial theory was reported by Horner1 for unsteady flow of single phase fluids of small but constant compressibility to a well producing at a constant rate in -infinite and closed boundary reservoirs. Extension of the theory to the finite reservoir case involves specification of the outer boundary condition. The two most commonly observed conditions are: (1) no flow at the outer boundary corresponding to a closed or depletion reservoir, and (2) constant pressure at the outer boundary corresponding to complete water-drive.
Reconstitution of circularized nanodiscs using SpyCatcher-SpyTag
Authors: Zhang Shangwen , Ren Qian , Bao Huan 
Published: November 2021

Abstract
Circularized nanodiscs (cNDs) with diameters over 20 nm are useful tools for biochemical reconstitutions of membrane protein complexes1. However, the application of these large cNDs is limited by low yields and time-consuming procedures. To address this challenge, we herein present a protocol to ease the reconstitution of large cNDs using the SpyCatcher-SpyTag technology.
Collateral Predictors of Neovascularization After Indirect Revascularization in Adult Patients with Moyamoya Disease: A Single-Center Retrospective Study
Authors: Dai Kefang , Shi Zhiyong , Liu Xingju , Wang Rong , Zhang Yan , Zhang Dong 
Published: November 2021

Abstract
Objective.

The underlying factors of neovascularization after indirect bypass in the adult patients with moyamoya disease (MMD) remained unknow. The aim of this study was to explore potential predictors based on collateral characteristics for neovascularization after indirect bypass in adult MMD patients.
Methods.

The adult MMD patients treated by indirect bypass in a single-institution from August 2012 and January 2018 were retrospectively selected into our research. The collaterals based on cerebral angiography were classified into the following subtypes: intracerebral anastomosis, duro-cortical anastomosis, and leptomeningeal anastomosis. Neovascularization evaluation was based on Matsushima classification, with “good” collateral formation in level 2 and 3, and poor formation in level 0 and 1. Univariate and multivariate analyses were performed to identify neovascularization predictors after indirect bypass.
Results.

A total of 86 patients (97 hemispheres) (mean ± SD age 35.06 ± 15.09 years, range 18–61 years) were retrospectively included. Preoperative collateral circulation included intracerebral anastomosis in 49 (50.5%) cases, duro-cortical anastomosis in 19 (19.6%) cases, and leptomeningeal anastomosis in 29 (29.9%) cases, respectively. Postoperative good neovascularization was observed in 56 (57.7%) hemispheres. Multivariate analysis showed that intracerebral anastomosis (P<0.001, OR [95% CI] 2.984 [2.031-5.437]) was associated with favorable neovascularization, whereas older age (P<0.001, OR [95% CI] 0.827 [0.793-0.916]) and hemorrhagic onset (P<0.001, OR [95% CI] 0.138 [0.054–0.353]) were significantly associated with poor neovascularization. Hemispheres in the good neovascularization had lower modified Rankin scale score, and better long-term improvement than those in the poor neovascularization.
Conclusions.

Hemorrhagic onset and old age predict poor neovascularization after indirect bypass, while duro-cortical anastomosis and intracerebral anastomosis predict good neovascularization. Good neovascularization was associated with better long-term outcomes. The current study provides a basis for the selection of surgical procedure for MMD candidates.
Optimal Threshold of Urinary Albumin-to-Creatinine Ratio (UACR) for Predicting Long-Term Cardiovascular and Noncardiovascular Mortality
Authors: Yang Zhi-wen , Fu Yan-bin , Wei Xue-biao , Huang Jie-leng , Fu Bing-qi , Zhang Guan-rong , Yu Danqing 
Published: November 2021

Abstract
Background Traditional cutoff values of urinary albumin-to-creatinine ratio (UACR) for predicting mortality have recently been challenged. In this study, we investigated the optimal threshold of UACR for predicting long-term cardiovascular and noncardiovascular mortality in the general population.Methods Data for 25,302 adults were extracted from the National Health and Nutrition Examination Survey (2005–2014), with mortality status obtained by data matching with death certificates in the National Death Index until December 31, 2015. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of UACR for cardiovascular and noncardiovascular mortality. A Cox regression model was established to examine the association between UACR and cardiovascular and noncardiovascular mortality. X-tile was used to estimate the optimal cutoff of UACR.Results The UACR had acceptable predictive value for both cardiovascular (area under the ROC curve [AUC]=0.769, 95% confidence interval [CI]: 0.711–0.828) and noncardiovascular (AUC=0.722, 95% CI: 0.681–0.764) mortality. Excellent linearity was observed between log-transformed UACR and cardiovascular and noncardiovascular mortality. The optimal cutoff values were 16 and 30 mg/g for predicting long-term cardiovascular and noncardiovascular mortality, respectively. The adjusted hazard ratios of cardiovascular and noncardiovascular mortality for the high-risk group were 2.55 (95% CI: 2.03–3.22, P<0.001) and 1.94 (95% CI: 1.72–2.18, P<0.001), respectively.Conclusions Compared to the traditional cutoff value (30 mg/g), a UACR cutoff of 16 mg/g may be more sensitive for identifying patients at high risk for cardiovascular mortality in the general population.
Structural Equation Modeling and Management Role On The Control of Marek’s Disease Outbreaks in Amhara Region Ethiopia
Authors: Birhan Mastewal , Berhane Nega , Bitew Molalegne , Gelaye Esayas , Getachew Belayneh , Abayneh Takele 
Published: November 2021

Abstract
Background

Marek’s disease is a highly contagious and economically important oncogenic or paralytic viral disease of poultry and it is becoming a serious problem in the poultry industry of Ethiopia. A questionnaire was designed based on the framework to confirmed how the farm management is reduced the outback of the mark’s diseases. Each model construct was measured using a set of rating scale items (questions). A sample size of 200 farmers from different production systems were chosen for data collection. From the analysis, Cornbrash’s Alpha (coefficient of reliability) based on the average inter-item correlations were evaluated for each parameter. This structural equation model examines the relationship between risk factors (flock size, litter management, number of staff) and the risk of each farm (numbers of sick, drops in egg production, and the number of death).
Results

When litter management goes up by 1, the number of sick goes down by 37.575, the number of staff goes up by 1, the number of sick goes down by 7.63, litter management goes up by 1, the number of death goes down by 2.505, flock size goes up by 1, and the number of death goes down by 0.007.than the rest of the activities. The result of this structural equation modeling the finding indicates that the data fit the model well (Chi-square =0.201, root mean square error of approximation = 0.000, the comparative fit index = 1.00, the tucker-lewis coefficient = 1.496, Degrees of freedom =2) and the model was appropriated.
Conclusions

Therefore, it can be concluded that the model must give due attention to the risk factors such as flock size, litter management, number of staff which is different from the previous research result and this might be due to the fact that the effects of environmental factors are more on procurement and integration than the other farm risk factors.
En Bloc Resection of Right Renal Cell Carcinoma and Inferior Vena Cava with Tumor Thrombus: Is It Safe to Divide the Left Renal Vein?
Authors: Horodyski Laura , Gonzalez Javier , Tabbara Marina M. , Gaynor Jeffrey J. , Rodriguez-Cabero Maria , Herranz-Amo Felipe , Hernández Carlos , Shah Rushi , Ciancio Gaetano 
Published: November 2021

Abstract
Background
It has been suggested that IVC reconstruction of retroperitoneal tumors is not required when adequate collateral circulation is present, though transient rise in creatinine may occur post-operatively. There are no reports evaluating mid- and long-term effect on renal function in these patients. The purpose of this study is to assess whether resection of a right renal cell carcinoma and inferior vena cava with obstructing tumor thrombus is safe to perform without reconstructing the inferior vena cava with regard to long-term renal function.
Materials and Methods
A bi-institutional retrospective review was performed over an 18 year period, assessing patients with right renal cell carcinoma and obstructing level II-IV tumor thrombus.
Results
Twenty-two patients were included in the study. Median age was 62.5 (range 45-79) years old and 19 (86%) of the patients were male. One patient (5%) had a level II thrombus, 14 patients (64%) had a level III thrombus (IIIa n=3, IIIb n=6, IIIc n= 3, IIId n=2), and seven patients (32%) had a level IV thrombus. Intra-operatively, median estimated blood loss was 1.35 (range 0.2 – 25) L. The median length of hospital stay was 11 (range 5 – 50) days. Median preoperative creatinine was 1.20 (range 0.40 – 2.70) mg/dL and postoperatively, median creatinine was 1.3 (range 0.86 – 2.20) mg/dL. Median creatinine at 6 month and 12 months follow-up was 1.10 (range 0.5 – 1.6) and mg/dL 1.34 (range 0.6 – 2.0), respectively. Eight patients were lost to follow-up, and two died (one in the hospital, and the other three months post-operatively).
Conclusions
Resection of right renal cell carcinoma with inferior vena cava in the presence of an obstructing level II- IV tumor thrombus without reconstruction of the inferior vena cava appears not to have a significant adverse effect on long-term renal function.
Efficacy Evaluation and Prognosis Analysis of CT-Guided Radiofrequency Ablation for Non-Small Cell Lung Cancer
Authors: Pan Min , Xu Yufei , Jiang Xueqin , Ke Zhangyan , Ning Yajing , Han Xiaoyan , Jiang Zifeng , Zhu Yingying , Fang Lei , Zhang Yanbei , Fan Xiaoyun 
Published: November 2021

Abstract
Background: Lung cancer has a high morbidity and mortality, and has the highest incidence of all malignancies in men in China. In recent years, radiofrequency ablation (RFA) has become the fourth promising treatment for lung cancer.Method: We followed up patients with non-small cell lung cancer in the First Affiliated Hospital of Anhui Medical University to investigate the survival, complications and prognosis of RFA.Results: Among 34 patients, there were 25 men and nine women (age range 22–84 years; 64% aged 60–80 years. The mean diameter of lung lesions was 2.46±0.89 cm. The pathological types were adenocarcinoma (27/34, 79.41%) and squamous cell carcinoma (7/34, 20.59%). Half of the patients had reached stage IV at the time of the study. Sixteen patients had elevated carcinoembryonic antigen (CEA). Six patients did not receive any further treatment after RFA and nine received chemotherapy combined with targeted therapy. The median follow-up period was 18 (7.0–33.5) months. Complications of RFA were reported in 15 patients (44.12%) and the most common were pneumothorax and pleural effusion. The risk of complications was higher in smokers than in non-smokers (P<0.05). The median overall survival was 22 (2.58–41.42) months, and the overall survival rate was 69.78% (1 year), 59.10% (18 months) and 48.85% (2 years). The survival rate of patients with lung lesions diameter ≤2 cm was significantly higher than that of patients with lesion diameter >2 cm (P<0.05). The annual survival rate of patients with elevated serum CEA before RFA was significantly lower than that of patients with normal serum CEA (P<0.05). Patients with chemotherapy combined with tyrosine kinase inhibitors (TKIs) had significantly higher survival rates compared with patients with only chemotherapy or TKI/no treatment (P<0.05). Conclusion: CT-guided RFA is a safe and effective treatment for lung cancer. Small lesions and combined therapy can result in longer survival. Patients with serum increased CEA have poor survival.
DPEP1 Increases Drug Resistance in an ASCL2-Dependent Manner in Colon Cancer Cells and Correlates with Immune Cell Infiltration
Authors: Zeng Cheng , Shen Ying , Zhu Qi , Yang Chunxia , Wang Yue , Li Wenjing , Liu Jingsong , Dai Yuyang , Qi Guoping , Jin Jianhua , Liu Qian 
Published: November 2021

Abstract
Background: Dipeptidase 1 (DPEP1) is associated with several human cancers. However, its function in colon cancer remains unclear.Methods: DPEP1 expression was analyzed by TCGA and GTEx pancancer data. Survival analysis was performed using the R survival package to assess the prognostic value of the DPEP1 expression level in colon cancer. DPEP1 enrichment analysis was conducted by the clusterProfiler R software package. Correlation analysis, differential expression analysis, and Venn analysis were used to obtain key genes. Correlation of DPEP1 or ASCL2 expression with immune cell infiltration in colon cancer was performed by TIMER and GSCA databases. qRT-PCR, Western blot, Co-immunoprecipitation, dual luciferase reporter experiments, and immunohistochemistry were used to explore the correlation between DPEP1 and ASCL2. MTT was used to evaluate the role of DPEP1 in colon cancer drug resistance.Results: DPEP1 was overexpressed in various cancers, including colon cancer. High DPEP1 expression was negatively correlated with the disease-specific survival (DSS) and progression-free interval (PFI) but not significantly correlated with the overall survival (OS). Enrichment analysis showed that DPEP1 may be related to the Wnt signaling pathway and Hippo signaling pathway. Further analysis showed that DPEP1 and ASCL2 had a strong positive correlation, and both correlated with immune cell infiltration. Moreover, DPEP1 enhanced drug resistance in an ASCL2- dependent manner.Conclusions: Our findings revealed that DPEP1 enhanced drug resistance in an ASCL2-dependent manner and correlated with immune infiltration in colon cancer.
Bacterial Foraging Algorithm With Potential Field Guidance Mechanism
Authors: Li Zhiyuan , Wang Zhicheng 
Published: November 2021

Abstract
To address the problems of weak quorum sensing ability and slow convergence speed in bacterial foraging algorithm, a bacterial foraging algorithm with potential field guidance mechanism is proposed. The algorithm combines the sampling guidance mechanism in the artificial potential field algorithm to provide the optimization direction for each bacterium; The original swimming operation of bacterial foraging algorithm is used to realize the local optimization strategy, and the local dimension update is added after swimming, so that the search range of bacteria in chemotaxis operation is wider; In the elimination and dispersal operation of bacterial foraging algorithm, double Gaussian function is introduced to re initialize the location of bacteria, so as to better avoid the algorithm falling into local extremum and improve the optimization ability of the algorithm. The experimental results show that the improved bacterial foraging algorithm has better optimization ability than the basic bacterial foraging algorithm.
PI3K/AKT/mTOR Signaling Pathway Regulates MMP9 Gene Activation via Transcription Factor NF-κB in Mammary Epithelial Cells of Dairy Cows
Authors: Mao Yongjin , Su Chen , Yang Huilin , Zhao Feng , Qu Bo , Zhao Bing , Cui Yingjun 
Published: November 2021

Abstract
Background

Matrix metalloproteinase 9 (MMP9) plays a pivotal role in mammary ductal morphogenesis, angiogenesis, and glandular tissue architecture remodeling. However, the molecular mechanism of MMP9 expression in mammary epithelial cells of dairy cows remains unclear. The current study aimed to explore the underlying mechanism of MMP9 expression.
Results

In this study, to determine whether the PI3K/AKT/mTOR/NF-κB signaling pathway participates in the regulation of MMP9 expression, we treated mammary epithelial cells with specific pharmacological inhibitors of PI3K (LY294002), mTOR (Rapamycin), or NF-κB (Celastrol), respectively. Western blotting results indicated that LY294002, Rapamycin, and Celastrol markedly decreased MMP9 expression and P65 nuclear translocation. Furthermore, we found that NF-κB (P65) overexpression resulted in elevated expression of MMP9 protein and activation of MMP9 promoter. In addition, we observed that Celastrol markedly decreases P65-overexpression-induced MMP9 promoter activity. Moreover, the results of the promoter assay indicated that the core regulation sequence for MMP9 promoter activation may be located -80bp to -420bp downstream from the transcription start site.
Conclusions

These observations indicated that the PI3K/AKT/mTOR signaling pathway is involved in MMP9 expression by regulating MMP9 promoter activity via NF-κB in the mammary epithelial cells of dairy cows.