bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interacting quintessence in light of generalized uncertainty principle: cosmological perturbations and dynamics
Authors: Paliathanasis Andronikos , Leon Genly , Khyllep Wompherdeiki , Dutta Jibitesh , Pan Supriya 
Published: July 2021

AbstractWe consider a cosmological scenario endowed with an interaction between the universe’s dark components – dark matter and dark energy. Specifically, we assume the dark matter component to be a pressure-less fluid, while the dark energy component is a quintessence scalar field with Lagrangian function modified by the quadratic Generalized Uncertainty Principle. The latter modification introduces new higher-order terms of fourth-derivative due to quantum corrections in the scalar field’s equation of motion. Then, we investigate asymptotic dynamics and general behaviour of solutions of the field equations for some interacting models of special interests in the literature. At the background level, the present interacting model exhibits the matter-dominated and de Sitter solutions which are absent in the corresponding quintessence model. Furthermore, to boost the background analysis, we study cosmological linear perturbations in the Newtonian gauge where we show how perturbations are modified by quantum corrected terms from the quadratic Generalized Uncertainty Principle. Depending on the coupling parameters, scalar perturbations show a wide range of behavior.
Manifest form of the spin-local higher-spin vertex $$\varUpsilon ^{\eta \eta }_{\omega CCC}$$
Authors: Gelfond O. A. , Korybut A. V. 
Published: July 2021

AbstractVasiliev generating system of higher-spin equations allowing to reconstruct nonlinear vertices of field equations for higher-spin gauge fields contains a free complex parameter $$\eta $$
η
. Solving the generating system order by order one obtains physical vertices proportional to various powers of $$\eta $$
η
and $${\bar{\eta }}$$

η

¯

. Recently $$\eta ^2$$

η
2

and $${\bar{\eta }}^2$$

η

¯

2

vertices in the zero-form sector were presented in Didenko et al. (JHEP 2012:184, 2020) in the Z-dominated form implying their spin-locality by virtue of Z-dominance Lemma of Gelfond and Vasiliev (Phys. Lett. B 786:180, 2018). However the vertex of Didenko et al. (2020) had the form of a sum of spin-local terms dependent on the auxiliary spinor variable Z in the theory modulo so-called Z-dominated terms, providing a sort of existence theorem rather than explicit form of the vertex. The aim of this paper is to elaborate an approach allowing to systematically account for the effect of Z-dominated terms on the final Z-independent form of the vertex needed for any practical analysis. Namely, in this paper we obtain explicit Z-independent spin-local form for the vertex $$\varUpsilon ^{\eta \eta }_{\omega CCC}$$

Υ

ω
C
C
C

η
η

for its $$\omega CCC$$

ω
C
C
C

-ordered part where $$\omega $$
ω
and C denote gauge one-form and field strength zero-form higher-spin fields valued in an arbitrary associative algebra in which case the order of product factors in the vertex matters. The developed formalism is based on the Generalized Triangle identity derived in the paper and is applicable to all other orderings of the fields in the vertex.
Estimation of temperature of cosmological apparent horizons: a new approach
Authors: Chatterjee Bhramar , Banerjee Narayan 
Published: July 2021

AbstractWe consider radiation from cosmological apparent horizon in Friedmann–Lemaitre–Robertson–Walker (FLRW) model in a double-null coordinate setting. As the spacetime is dynamic, there is no timelike Killing vector, instead we have Kodama vector which acts as dynamical time. We construct the positive frequency modes of the Kodama vector across the horizon. The conditional probability that a signal reaches the central observer when it is crossing from the outside gives the temperature associated with the horizon.
Flavored axion in the UV-complete Froggatt–Nielsen models
Authors: de la Vega Leon M. G. , Nath Newton , Nellen Stefan , Peinado Eduardo 
Published: July 2021

AbstractWe propose UV-completions of Froggatt–Nielsen–Peccei–Quinn models of fermion masses and mixings with flavored axions, by incorporating heavy fields. Here, the U(1) Froggatt–Nielsen symmetry is identified with the Peccei–Quinn symmetry to solve the strong CP problem along with the mass hierarchies of the Standard Model fermions. We take into account leading order contributions to the fermion mass matrices giving rise to Nearest-Neighbour-Interaction structure in the quark sector and $$A_2$$

A
2

texture in the neutrino sector. A comprehensive numerical analysis has been performed for the fermion mass matrices. Subsequently, we investigate the resulting axion flavor violating couplings and the axion-photon coupling arising from the model.
A Guideline on Pseudorandom Number Generation (PRNG) in the IoT
Authors: Kietzmann Peter , Schmidt Thomas C. , Wählisch Matthias 
Published: July 2021

Random numbers are an essential input to many functions on the Internet of Things (IoT). Common use cases of randomness range from low-level packet transmission to advanced algorithms of artificial intelligence as well as security and trust, which heavily rely on unpredictable random sources. In the constrained IoT, though, unpredictable random sources are a challenging desire due to limited resources, deterministic real-time operations, and frequent lack of a user interface.
In this article, we revisit the generation of randomness from the perspective of an IoT operating system (OS) that needs to support general purpose or crypto-secure random numbers. We analyze the potential attack surface, derive common requirements, and discuss the potentials and shortcomings of current IoT OSs. A systematic evaluation of current IoT hardware components and popular software generators based on well-established test suits and on experiments for measuring performance give rise to a set of clear recommendations on how to build such a random subsystem and which generators to use.
Applying Machine Learning for Sensor Data Analysis in Interactive Systems
Authors: PlÖtz Thomas 
Published: July 2021

With the widespread proliferation of (miniaturized) sensing facilities and the massive growth and popularity of the field of machine learning (ML) research, new frontiers in automated sensor data analysis have been explored that lead to paradigm shifts in many application domains. In fact, many practitioners now employ and rely more and more on ML methods as integral part of their sensor data analysis workflows—thereby not necessarily being ML experts or having an interest in becoming one. The availability of toolkits that can readily be used by practitioners has led to immense popularity and widespread adoption and, in essence, pragmatic use of ML methods. ML having become mainstream helps pushing the core agenda of practitioners, yet it comes with the danger of misusing methods and as such running the risk of leading to misguiding if not flawed results.
Based on years of observations in the ubiquitous and interactive computing domain that extensively relies on sensors and automated sensor data analysis, and on having taught and worked with numerous students in the field, in this article I advocate a considerate use of ML methods by practitioners, i.e., non-ML experts, and elaborate on pitfalls of an overly pragmatic use of ML techniques. The article not only identifies and illustrates the most common issues, it also offers ways and practical guidelines to avoid these, which shall help practitioners to benefit from employing ML in their core research domains and applications.
MicroRNA-324-5p–CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness
Authors: Ghatak Dishari , Datta Arindam , Roychowdhury Tanaya , Chattopadhyay Samit , Roychoudhury Susanta 
Published: July 2021

Abstract

Regulation of cancer stemness has recently emerged as a new gain-of-function (GOF) property of mutant p53. In this study, we identify miR-324-5p as a critical epigenetic regulator of cancer stemness and demonstrate its role in mediating GOF-mutant p53-driven stemness phenotypes. We report that miR-324–5p is upregulated in human cancer cell lines and non–small cell lung carcinoma (NSCLC) tumors carrying TP53 GOF mutations. Mechanistically, we show that GOF mutant p53 upregulates miR-324–5p expression via c-Myc, an oncogenic transcription factor in cancer cells. Our experimental results suggest that miR-324–5p–induced CSC phenotypes stem from the downregulation of CUEDC2, a downstream target gene of miR-324–5p. Accordingly, CUEDC2 complementation diminishes elevated CSC marker expression in miR-324–5p–overexpressing cancer cells. We further demonstrate that mutant p53 cancer cells maintain a low level of CUEDC2 that is rescued upon miR-324–5p inhibition. Importantly, we identify CUEDC2 downregulation as a novel characteristic feature of TP53-mutated human cancers. We show that activation of NF-κB due to downregulation of CUEDC2 by miR-324–5p imparts stemness in GOF mutant p53 cancer cells. Finally, we provide evidence that TP53 mutations coupled with high miR-324–5p expression predict poor prognosis in patients with lung adenocarcinoma. Thus, our study delineates an altered miR-324–5p-CUEDC2-NF-κB pathway as a novel regulator of GOF mutant p53-driven cancer stemness.

Implications:
Our findings implicate miRNA-324–5p as a novel epigenetic modifier of human cancer stemness.
Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53–Mdm2 Axis
Authors: Mohibi Shakur , Zhang Jin , Chen Mingyi , Chen Xinbin 
Published: July 2021

Abstract

p53 transcription factor is activated upon exposure to various cellular stresses, leading to growth suppression. However, aberrant activation of p53 can lead to defects in embryonic development and other abnormalities. Here, we identified zinc finger protein Zfp871 as a p53 target gene. We showed that as an RNA-binding protein, Zfp871 binds to Mdm2 3′UTR and stabilizes Mdm2 mRNA, which in turn suppresses p53 expression through increased expression of Mdm2 E3 ubiquitin ligase. Consistently, Zfp871 deficiency increases p53 expression, leading to growth suppression in a p53-dependent manner. To determine the role of Zfp871 in the p53 pathway, we used Zfp871-deficient mouse model and found that Zfp871-null mice were prone to embryonic/pre-weaning lethality, which can be partially rescued by simultaneous deletion of Trp53. We also found that mice heterozygous for Zfp871 had a short lifespan and were susceptible to steatohepatitis but not to spontaneous tumors. To determine the underlying mechanism, RNA-seq analysis was performed and showed that an array of genes involved in development, lipid metabolism, and inflammation is regulated by Zfp871 in conjunction with p53. Taken together, we conclude that the Zfp871–Mdm2–p53 pathway plays a critical role in tumor-free survival and development.

Implications:
A fine equilibrium of p53 is required for preventing damaging effects of aberrant p53 expression. We identify the Zfp871–Mdm2–p53 pathway that plays a critical role in development of mice and steatohepatitis.
Ankle-Brachial Index for Risk Stratification in Patients With Symptomatic Peripheral Artery Disease With and Without Prior Lower Extremity Revascularization: Observations From the EUCLID Trial
Authors: Hiatt William R. , Hess Connie N. , Bonaca Marc P. , Kavanagh Sarah , Patel Manesh R. , Baumgartner Iris , Berger Jeffrey S. , Blomster Juuso I. , Jones W. Schuyler , Katona Brian G. , Mahaffey Kenneth W. , Norgren Lars , Rockhold Frank W. , Fowkes F. Gerry R. 
Published: July 2021

Background:
A reduced ankle-brachial index (ABI) is a measure of atherosclerosis and is associated with ischemic risk in the general population. Whether this relationship is maintained in peripheral artery disease after lower extremity revascularization (LER), which can modify ABI, is unknown.

Methods:
The EUCLID (Examining Use of Ticagrelor in Peripheral Artery Disease) enrolled 13 885 patients with symptomatic peripheral artery disease; 57% with prior LER, and 43% with ABI ≤0.80. The primary major adverse cardiovascular events (MACE) outcome was a composite of cardiovascular death, myocardial infarction, or ischemic stroke. Major adverse limb events (MALE) included acute limb ischemia and major amputation. An adjusted Cox proportional hazards model demonstrated a nonlinear relationship between ABI and outcomes. A restricted cubic spline model with 4 knots was developed to identify the best fitting model to describe the relationship between ABI and MACE and MALE risk.

Results:

Baseline ABI (mean±SD) was 0.77±0.21 in participants with prior LER and 0.63±0.14 in those without prior LER (
P
<0.0001). There was no statistical interaction between prior LER and ABI, meaning the shapes of the cubic spline models were similar between groups. In those with prior LER, for every 0.10 unit lower ABI below an ABI of 1.00, the hazard ratio for MACE was 1.08 (95% CI, 1.04–1.12;
P
<0.0001), below an ABI of 0.80 the hazard ratio for MALE was 1.32 (95% CI, 1.21–1.43;
P
<0.0001). In patients without prior LER, every 0.10 unit lower ABI below an ABI of 0.70 was associated with increased risk for MACE (hazard ratio, 1.14 [95% CI, 1.06–1.23];
P
=0.0004) and MALE (hazard ratio, 1.27 [95% CI, 1.08–1.49];
P
=0.003).

Conclusions:
Patients with established peripheral artery disease, particularly those with prior LER, have an increased risk of MACE and MALE. The ABI remains a strong predictor of MACE and MALE ischemic events with an inverse relationship below an ABI threshold for patients with and without prior LER.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01732822.
Industrial Designs Protection in Qatar: An Analytical Study of Industrial Designs and Models Law No. 10 of 2020
Authors: El-Farag Mohamed Salem Abou , Al-Muraikhi Shaikha Jaber S.H. 
Published: July 2021

Abstract
For the industrial development of national economic industries in any given country, designs for products and goods need to be created and developed. In 2020, Qatar issued a new law on Industrial Designs and Models (Law No. 10 of 2020) as a means of enhancing and strengthening Intellectual Property Rights and their protection, which is regarded as a part of Qatar’s National Vision 2030. In this article, the provisions of the new law will be critically examined. The discussion starts by highlighting the definition of, and the requirements for, protection. The rights granted to the owner of the design will also be explored. A comparison between the Qatari provisions and those from a number of other countries will be made throughout. The main purpose of this paper is to provide a comprehensive analysis of the new law on industrial designs, taking into consideration the legal development of those jurisdictions.
Ubuntu Apologetics in Faith Formation
Authors: Ndereba Kevin Muriithi 
Published: July 2021

Abstract
Faith formation is a crucial area in youth ministry. Although the area of apologetics may be a helpful bridge, the theory and praxis of apologetics in the African context is scanty. The work of apologists such as William Lane Craig, John Frame, Ravi Zacharias, and John Lennox has responded to the post-Christian context of Europe and North America. Much needs to be done in light of the African contextual realities. Using a practical theological methodology, this paper considers how ubuntu apologetics – which honors both the cognitive and affective development of adolescents – can lead to holistic faith formation of African youth. This research paper will 1) consider youth ministry contextual realities in Kenya and Africa; 2) analyze foundational methods of apologetics; 3) utilize an ethnographic methodology in analyzing the data and 4) offer recommendations for youth ministry education and practice in Nairobi and Africa at large.
Controversies about Religious Organisations within an Evolving Taiwan Civil Society
Authors: Madsen Richard 
Published: July 2021

Abstract
A staple of political theory is that democracy depends on a vibrant civil society. What are the indicators of such a society? Is it the number of voluntary associations, their relative independence from government, the content of their activities, their systemic relationships with one another—and/or the way the relationships among these variables are evolving over time? In this paper, I place special emphasis on the systemic relationships among civil society organisations and their evolution over time, and I revisit some of the findings from the book Democracy’s Dharma to show how this emphasis might offer a new perspective on the development of Taiwan’s civil society today.
Diurnal variability of frontal dynamics, instability, and turbulence in a submesoscale upwelling filament
Authors: Peng Jen-Ping , Umlauf Lars , Dräger-Dietel Julia , North Ryan P. 
Published: July 2021

AbstractRecent high-resolution numerical simulations have shown that the diurnal variability in the atmospheric forcing strongly affects the dynamics, stability, and turbulence of submesoscale structures in the surface boundary layer (SBL). Field observations supporting the real-ocean relevance of these studies are, however, largely lacking at the moment. Here, the impact of large diurnal variations in the surface heat flux on a dense submesoscale upwelling filament in the Benguela upwelling system is investigated, based on a combination of densely-spaced turbulence microstructure observations and surface drifter data. Our data show that during nighttime and early-morning conditions, when solar radiation is still weak, frontal turbulence is generated by a mix of symmetric and shear instability. In this situation, turbulent diapycnal mixing is approximately balanced by frontal restratification associated with the cross-front secondary circulation. During daytime, when solar radiation is close to its peak value, the SBL quickly restratifies, the conditions for frontal instability are no longer fulfilled, and SBL turbulence collapses except for a thin wind-driven layer near the surface. The drifter data suggest that inertial oscillations periodically modulate the stability characteristics and energetics of the submesoscale fronts bounding the filament.
Modeling Users’ Trust in Drought Forecasts
Authors: Shafiee-Jood Majid , Deryugina Tatyana , Cai Ximing 
Published: July 2021

AbstractForecast valuation studies play a key role in understanding the determinants of the value of weather and climate forecasts. Such understanding provides opportunities to increase the value that users can obtain from forecasts, which can in turn increase the use of forecasts. One of the most important factors that influences how users process forecast information and incorporate forecasts into their decision-making is trust in forecasts. Despite the evidence from empirical and field-based studies, modeling users’ trust in forecasts has not received much attention in the literature and is therefore the focus of our study. We propose a theoretical model of trust in information, built into a forecast valuation framework, to better understand 1) the role of trust in users’ processing of drought forecast information and 2) the dynamic process of users’ trust formation and evolution. Using a numerical experiment, we show that considering the dynamic nature of trust is critical in more realistic assessment of forecast value. We find that users may not perceive a potentially valuable forecast as such until they trust it enough, implying that exposure to even highly accurate forecasts may not immediately translate into forecast use. Ignoring this dynamic aspect could overestimate the economic gains from forecasts. Furthermore, the model offers hypotheses with regard to targeting strategies that can be tested with empirical and field-based studies and used to guide policy interventions.
Cocreation for Climate Change—Needs for Actions to Vitalize Drivers and Diminish Barriers
Authors: Fagiewicz K. , Churski P. , Herodowicz T. , Kaczmarek P. , Lupa P. , Morawska-Jancelewicz J. , Mizgajski A. 
Published: July 2021

AbstractThis study determines the conditions and provides a recommendation for fostering cocreation for climate change adaptation and mitigation (CCA&M). In postulating that insufficient cocreation by stakeholders in the quadruple helix model is an important factor contributing to the low effectiveness of climate actions in the regions, we have focused our research on identifying real stakeholder engagement in climate action and identifying the needs, barriers, and drivers for strengthening the cocreation process. We identified the needs for action highlighted by stakeholders as having an impact on reducing barriers and stimulating drivers. We treated the identified needs for action as deep leverage points (intent and design) focused on three realms—knowledge, values, and institutions—in which engagement and cocreation can be strengthened and have the potential to increase the effectiveness of climate action taken by stakeholders within our quadruple helix. We recommend knowledge-based cocreation, which puts the importance of climate action in the value system and leads to paradigm reevaluation. The implementation of the identified needs for action requires the support of institutions, whereby they develop standards of cooperation and mechanisms for their implementation as a sustainable framework for stakeholder cooperation. The research has proved how the quadruple helix operates for climate action in the Poznań Agglomeration. We believe that this case study can be a reference point for regions at a similar level of development, and the methods used and results obtained can be applied in similar real contexts to foster local stakeholders in climate action.
Insight in nonpsychotic disorders: A new model of insight and a systematic review of measures
Authors: Halaj Asala , Huppert Jonathan D 
Published: July 2021

Objective: There is substantial research examining insight in psychotic disorders and in some nonpsychotic disorders. However, there has been little attention given to many nonpsychotic disorders. Research on insight in psychosis distinguishes between cognitive and clinical insight. In most studies examining insight in nonpsychotic disorders, definitions and assessments of insight vary significantly. The purpose of this review is to suggest a definition of insight in nonpsychotic disorders such that it can be used across different disorders. Method: We systematically review the extant literature of insight in nonpsychotic disorders and analyze the assessments used in order to determine how well they capture these two types of insight. Then, we discuss how these two constructs can provide better understanding of the phenomenology of insight in nonpsychotic disorders. Results: The systematic search resulted in 99 articles. These articles used 17 different methods of measuring insight, containing 127 questions. Results of the content analysis of items suggested that measures of insight used in nonpsychotic disorders do not distinguish between cognitive and clinical insight, but that most questions (90%) can indeed be reliably differentiated. Conclusion: We provide a multidimensional model of cognitive and clinical insight in nonpsychotic disorders, emphasizing the complexity of assessment and the importance of accurately defining insight. Such definitions have important theoretical and clinical implications, offering a better understanding of the concept of insight in nonpsychotic disorders.