bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Hydrate Exploitation On Stability of Submarine Slopes
Authors: Zhao Yapeng , Kong Liang , Liu Lele , Liu Jiaqi 
Published: December 2021

Abstract
The decomposition of natural gas hydrate will reduce the cementation effect of hydrate and produce ultra-static pore pressure, which will change the mechanical characteristics of the reservoir. Eventually, a series of geological disasters could be triggered, of which the submarine landslide is a typical example. In order to analyze the stability of hydrate-bearing submarine slopes and to explore the internal relationship between hydrate decomposition and submarine landslides, a “two-step reduction method” was described in this paper. This method was based on a strength reduction approach, which can be used to assess the effects of the initial geostress balance and hydrate decomposition on substrate strength reduction. This method was used to reveal the essence of hydrate decomposition and then a joint operation mode of multi-well was proposed. The internal relationship between hydrate decomposition and submarine landslides were analyzed in detail. And the development process and mechanism of submarine landslide were deeply discussed. The results showed that hydrate decomposition is a dynamic process of stress release and displacement, where the “stress inhomogeneity” distributed along the slope is transformed into “displacement inhomogeneity”. We concluded that hydrate decomposition could trigger a submarine landslide, especially along a sliding surface. The formation of submarine landslide is a gradual development process, and presents the dual characteristics of time and space.
Focus group findings on clinicians’ perceived barriers and facilitators to giving rights information to involuntary psychiatrics patients in British Columbia, Canada
Authors: Cheung Iva W. , Silva Diego S. , Miller Kimberly J. , Michalak Erin E. , Goldsmith Charles H. 
Published: December 2021

Abstract

Background

In British Columbia, Canada, clinicians are responsible for giving information about rights to patients involuntarily hospitalized under the Mental Health Act. But a survey commissioned by the Ministry of Health and an investigation by the BC Office of the Ombudsperson found that patients were not consistently receiving rights information.
Methods

Focus groups were used to probe clinicians’ perceived barriers and facilitators to giving patients rights information. Focus group transcripts were thematically analyzed, and the themes were coded using the Theoretical Domains Framework to identify interventions that could encourage clinicians to consistently give patients complete rights information.
Results

Eighty-one psychiatric clinicians participated. Analysis identified these barriers: (a) clinicians receive inadequate training on the Mental Health Act and rights notification; (b) newly admitted patients might not be receptive to new information; (c) the tool used to communicate rights to patients is inadequate; (d) many patients don’t speak English; (e) clinicians have competing priorities during the admission process; (f) clinicians face pressure from other staff to give incomplete information; (g) the clinical workflow doesn’t facilitate follow-up and accountability; and (h) staff don’t receive enough support from their employer. The following facilitators were identified: (a) a team approach allows clinicians to share knowledge about the Mental Health Act and rights notification, (b) having one person take responsibility for rights information clarifies roles and increases accountability, (c) accreditation reminds clinicians of the importance of giving patients rights information, and (d) checklists remind clinicians of their rights-notification responsibilities.
Conclusions

These interventions may help clinicians give rights information more consistently: (a) training about the Mental Health Act and rights notification, (b) an accessible legal resource for clinicians and patients, (c) regular group sessions about rights for patients, (d) an improved rights-communication tool, in multiple languages, and (e) checklists, reminders, and accountability and feedback systems.
Spin-Thermoelectric Effects in a Quantum Dot Hybrid System With Magnetic Insulator
Authors: Trocha Piotr , Siuda Emil 
Published: December 2021

Abstract
We investigate spin thermoelectric properties of a hybrid system consisting of a single-level quantum dot attached to magnetic insulator and metal electrodes. Magnetic insulator is assumed to be of ferromagnetic type and is a source of magnons, whereas metallic lead is reservoir of electrons. The temperature gradient set between the magnetic insulator and metallic electrodes induces the spin current flowing through the system. The generated spin current of magnonic (electric) type is converted to electric (magnonic) spin current by means of quantum dot. Expanding spin and heat currents flowing through the system, up to linear order, we introduce basic spin thermoelectric coefficients including spin conductance, spin Seebeck and spin Peltier coefficients and heat conductance. We analyse the spin thermoelectric properties of the system in two cases: in the large ondot Coulomb repulsion limit and when these interactions are finite.
Taxonomic Dependency of Beta Diversity for Bacteria, Archaea and Fungi in a Semi-Arid Lake
Authors: Yuan Haijun , Zhang Weizhen , Yin Huaqun , Zhang Runyu , Wang Jianjun 
Published: December 2021

Abstract
Microbial beta diversity has been recently studied along the water depth in aquatic ecosystems, however its turnover and nestedness components remain elusive especially for multiple taxonomic groups. Based on the beta diversity partitioning developed by Baselga and Local Contributions to Beta Diversity (LCBD) partitioning by Legendre, we examined the water-depth variations in beta diversity components of bacteria, archaea and fungi in surface sediments of Hulun Lake, a semi-arid lake in northern China, and further explored the relative importance of environmental drivers underlying their patterns. We found that the relative abundances of Proteobacteria, Chloroflexi, Euryarchaeota and Rozellomycota increased towards deep water, while Acidobacteria, Parvarchaeota and Chytridiomycota decreased. For bacteria and archaea, there were significant (P < 0.05) decreasing water-depth patterns for LCBD and LCBDRepl (i.e., species replacement), while increasing patterns for total beta diversity and turnover, implying that total beta diversity and LCBD were dominated by species turnover or LCBDRepl. Further, bacteria showed a strong correlation with archaea regarding LCBD, total beta diversity and turnover. Such parallel patterns among bacteria and archaea were underpinned by similar ecological processes like environmental selection. Total beta diversity and turnover were largely affected by sediment total nitrogen, while LCBD and LCBDRepl were mainly constrained by water NO2−-N and NO3−-N. For fungal community variation, no significant patterns were observed, which may be due to different drivers like water nitrogen or phosphorus. Taken together, our findings provide compelling evidences for disentangling the underlying mechanisms of community variation in multiple aquatic microbial taxonomic groups.
African-specific prostate cancer molecular taxonomy
Authors: Hayes Vanessa , Jaratlerdsiri Weerachai , Jiang Jue , Gong Tingting , Patrick Sean , Willet Cali , Chew Tracy , Lyons Ruth , Haynes Anne-Maree , Pasqualim Gabriela , Louw Melanie , Kench James , Campbell Raymond , Chan Eva , Wedge David , Sadsad Rosemarie , Brum Ilma , Mutambirwa Shingai , Stricker Phillip , Bornman Riana , Horvath Lisa 
Published: December 2021

Abstract
Prostate cancer is characterised by significant global disparity; mortality rates in Sub-Saharan Africa are double to quadruple those in Eurasia1. Hypothesising unknown interplay between genetic and non-genetic factors, tumour genome profiling envisages contributing mutational processes2,3. Through whole-genome sequencing of treatment-naïve prostate cancer from 183 ethnically/globally distinct patients (African versus European), we generate the largest cancer genomics resource for Sub-Saharan Africa. Identifying ~2 million somatic variants, Africans carried the greatest burden. We describe a new molecular taxonomy using all mutational types and ethno-geographic identifiers, including Asian. Defined as Global Mutational Subtypes (GMS) A–D, although Africans presented within all subtypes, we found GMS-B to be ‘African-specific’ and GMS-D ‘African-predominant’, including Admixed and European Africans. Conversely, Europeans from Australia, Africa and Brazil predominated within ‘mutationally-quiet’ and ethnically/globally ‘universal’ GMS-A, while European Australians shared a higher mutational burden with Africans in GMS-C. GMS predicts clinical outcomes; reconstructing cancer timelines suggests four evolutionary trajectories with different mutation rates (GMS-A, low 0.968/year versus D, highest 1.315/year). Our data suggest both common genetic factors across extant populations and regional environmental factors contributing to carcinogenesis, analogous to gene-environment interaction defined here as a different effect of an environmental surrounding in persons with different ancestries or vice versa. We anticipate GMS acting as a proxy to intrinsic and extrinsic mutational processes in cancers, promoting global inclusion in landmark studies.
Nonlinear suboptimal attitude control law for near-space hypersonic vehicle: Eigenvalue analysis and weight matrices design
Authors: Mi Peichao , Wu Qingxian , Wang Yuhui 
Published: December 2021

Abstract
This paper considers a nonlinear suboptimal control problem for a near-space hypersonic vehicle's (NSHV's) attitude dynamics. The least-square and stable manifold methods first solve an unconstrained approximately optimal control law corresponding to the nonlinear attitude model. Then, to further meet the dynamic performance requirement of the attitude control system, a novel strategy based on the Koopman operator, symplectic geometric theory, and the stable manifold theorem is proposed to approximate the eigenvalues of the closed-loop nonlinear unconstrained approximated optimal control system. The weight matrices in the optimal performance index, which directly determine the output responses of the nonlinear attitude dynamics, can be appropriately designed according to the eigenvalues. The final control law considers the actuator constraints. The NSHV's closed-loop attitude control system is proved to be locally exponentially stable, and the suboptimality of the control law is analyzed. Numerical simulation demonstrates the effectiveness of the proposed scheme.
Equilibrium Optimizer with Generalized Opposition-based Learning for Multiple Unmanned Aerial Vehicles Path Planning
Authors: Chen Yang , Pi Dechang , Wang Bi , Mohamed Ali Wagdy , Chen Junfu 
Published: December 2021

Abstract
Multiple Unmanned Aerial Vehicles (UAVs) path planning is the benchmark problem of multiple UAVs application, which belongs to the non-deterministic polynomial problem. Its objective is to require multiple UAVs flying safely to the goal position according to their specific start position in three-dimensional space. This issue can be defined as a high-dimensional optimization problem, the solution of which requires optimization techniques with global optimization capabilities. Equilibrium optimizer (EO) is a population-based meta-heuristic algorithm. In order to improve the optimization ability of EO to solve high dimensional problems, this paper proposes a modified equilibrium optimizer with generalized opposition-based learning (MGOEO), which improves the population activity by increasing the internal mutation and cross of the population. In addition, the generalized opposition-based learning is used to construct the population, which can effectively ensure that the algorithm has ability to jump out of the limitation of local optimal. Firstly, numerical experiments show that MGOEO has better optimization precision than EO and several other swarm intelligent algorithms. Then, the paths of UAVs are simulated in three different obstacle environments. The simulation results show that MGOEO can obtain safe and smooth paths, which are better than EO and other eight state-of-the-art optimization algorithms.
Exosomal tRF-Leu-AAG-001 Derived from Mast Cell as a Potential Non-Invasive Diagnostic Biomarker for Endometriosis
Authors: Li Yingxue , Cui Shuling , Xu Zemin , Zhang Yanping , Wu Tao , Zhang Jing , Chen Yichen 
Published: December 2021

Abstract
Background: The diagnosis of endometriosis (EMs) is still based on laparoscopic observation. This study tries to verify whether exosomal tRNA-derived fragments (tRFs) in leucorrhea can be used as non-invasive diagnostic markers.Methods: Endometrial tissues and leucorrhea were sampled from women hospitalized in Ningbo University Affiliated Hospital from January 2021 to July 2021 with (n=26) and without endometriosis (n=25). Exosomes were isolated from samples by differential centrifugation. The small RNA sequencing was performed to detect the exosomal tRNA halves (tiRNAs)&tRFs. RNA probe and immunofluorescence antibody were used to localize the origin of tRFs. From mast cell lines infected with tRF-Leu-AAG-001 siRNA, we observed the change in vascular capacity and expression of inflammatory factors. The specificity and sensitivity tRF were determined by receiver operating characteristic analyses.Results: 63 up-regulated and 45 down-regulated tRFs&tiRNAs were identified in ectopic exosomes. We selected tRF-Leu-AAG-001 as a candidate marker through KEGG pathway enrichment and PCR verification. We found that mast cells highly expressed tRF-Leu-AAG-001 in ectopic foci by immunofluorescence staining. We used siRNA to silenced tRF-Leu-AAG-001 expression in luva, qPCR analysis showed IL-6, IL-10, IL-1β, and TNF-α were significantly decreased. Meanwhile, tRF-Leu-AAG-001 siRNA dramatically reduced the angiogenic ability of luva. Finally, we examined the expression of exosomal tRF-Leu-AAG-001 in the leucorrhea. It was found exosomal tRF-Leu-AAG-001 had high specificity and sensitivity for predicting the occurrence of ectopic disease. Conclusions: Exosomal tRF-Leu-AAG-001 derived from mast cells in ectopic foci might promote inflammation and angiogenesis. Meanwhile，leucorrhea exosomal tRF-Leu-AAG-001 could be a potential diagnostic biomarker for endometriosis.
Effect of Time Restricted Feeding on Anthropometric Measures, Body Composition, Eating Behavior, Stress, Brain Derived Neurotrophic Factor (BDNF) and Lipopolysaccharide Binding Protein (LBP) Levels in Food Addicted Over Weight and Obese Women: A Study Protocol for a RRandomized Clinical Trial
Authors: Irani Hanieh , Khodami Banafsheh , Abiri Behnaz , Saidpour Atoosa 
Published: December 2021

Abstract
Background: Food addiction, the desire to eat compulsively and excessively palatable foods, is one of the behavioral factors that plays an important role in pathogenesis of obesity. Food addiction, like drug addiction, changes the dopaminergic system in rewards region of brain, but at lower levels. There are evidence suggesting brain-derived neurotrophic factor (BDNF) is synthesized in dopaminergic pathways in the reward regions of the brain and is involved in regulating food intake and body weight. BDNF is also associated with eating disorders in humans and hyperphagia in mice. On the other hand, it has been shown that the intestinal microbiome is effective in eating behavior through the production of neuronal and hormonal mediators, including BDNF. Intestinal microbiome changes greatly under the influence of diet. It has been shown that a time-restricted feeding (TRF) has been able to maintain fluctuations in the intestinal microbiome in response to the body's circadian rhythm. Furthermore, increased pathogens in the gut are associated with increased release of polysaccharides from the bacterial wall, resulting in increased levels of lipopolysaccharide binding protein (LBP). This study will aim to evaluate the effect of TRF on anthropometric measures, body composition, eating behavior, stress level, BDNF and LBP levels in over weight and obese women with food addiction.Methods/design: we will carry on a randomized clinical trial for 8 weeks to evaluate the effect of a TRF on anthropometric measures, body composition, eating behavior, stress level, BDNF and LBP levels in obese and overweight women with food addiction.Discussion: Given the effect of BDNF on regulating eating behavior and body weight and the effect of dietary restrictions on BDNF and the gut microbiome, the TRF diet could possibly be a new way to successfully manage weight through modifying BDNF in people with eating disorders, including food addiction.Trial Registration: Iranian Registry of Clinical Trials. IRCT20131228015968N7. Registered on 2020-10-25.
Spatiotemporal Parameters And Gait Variability In People With Psoriatic Arthritis (Psa) : A Cross-Sectional Study.
Authors: Walha Roua , Gaudreault Nathaly , Dagenais Pierre , Boissy Patrick 
Published: December 2021

Abstract
Background: Foot involvement is a major manifestation of psoriatic arthritis (PsA) and could lead to severe levels of foot pain and disability and impaired functional mobility and quality of life. Gait spatiotemporal parameters (STPs) and gait variability, used as a clinical index of gait stability, have been associated with several adverse health outcomes including risk of falling, functional decline, and mortality in a wide range of populations. Previous studies showed some alterations in STPs in people with PsA. However, gait variability and the relationships between STPs, gait variability and self-reported foot pain and disability have never been studied in this populations. Body-worn inertial measurement units (IMUs) are gaining interest in measuring gait parameters in clinical settings.Objectives: To assess STPs and gait variability in people with PsA using IMUs and, to explore their relationship with self-reported foot pain and function and to investigate the feasibility of using IMUs to discriminate patient groups based on gait speed-critical values.Methods: 21 participants with PsA (Age: 53.9 ± 8.9 yrs; median disease duration: 6 yrs) and 21 age and gender-matched healthy participants (Age 54.23 ± 9.3 yrs) were recruited. All the participants performed three 10-meter walk test trials at their comfortable speed. STPs and gait variability were recorded and calculated using six body-worn IMUs and the Mobility Lab software (APDM®). Foot pain and disability were assessed in participants with PsA using the foot function index (FFI).Results: Cadence, gait speed, stride length, and swing phase, were significantly lower, while double support was significantly higher, in the PsA group (p< 0.006). Strong correlations between STPs and the FFI total score were demonstrated (|r|> 0.57, p< 0.006). Gait variability was significantly increased in the PsA group, but it was not correlated with foot pain and function (p< 0.006). Using the IMUs three subgroups of participants with PsA with clinically meaningful differences in self-reported foot pain and disability were discriminated.Conclusion: STPs were significantly altered in participants with PsA which could be associated with self-reported foot pain and disability. Future studies are required to confirm the increased gait variability highlighted in this study and its potential underlying causes. Using IMUs in clinical settings has been useful to objectively assess foot function in people with PsA. Study registration: ClinicalTrials.gov, NCT05075343, Retrospectively registered on 29 September 2021.
Tailoring Research Evidence and Theory (TREAT) into Allied Health Journal Clubs: A Hybrid Effectiveness-Implementation Study
Authors: Wenke Rachel , Wiseman Jodie , Brandenburg Caitlin , Stehlik Paulina , Hughes Ian , Richards Katherine , Mickan Sharon 
Published: December 2021

Abstract
BackgroundAllied Health Professionals (AHPs) commonly use journal clubs (JCs) to support Evidence-Based Practice (EBP). There is however little research regarding implementing JCs in the long term, and their impact on EBP use and skills in AHPs. This study investigated the impact of implementing a structured JC format, called “TREAT” that was specifically tailored for each club, on EBP skills, confidence, use and resultant changes in clinical practice over 16 sessions for AHPs in a public health service. The study also investigated AHP’s attendance, adherence, satisfaction and barriers and enablers to implementing the format.MethodsA mixed methods hybrid-effectiveness implementation design was employed, guided by the Knowledge-to-Action cycle. EBP skills, confidence, use, and attitudes were assessed (Adapted Fresno Test, EBPQ, tailored journal club culture questionnaire) at baseline, and after 10 and 16-monthly JC sessions. Satisfaction and impact on clinical practice were explored using questionnaires at the latter two time-points, with free-form responses identifying enablers and barriers to EBP culture and implementation. Data on attendance and adherence to the TREAT format were also collected. ResultsSix JCs comprising a total of 132 unique participants from seven Allied Health professions were assessed across three time points. EBP skills significantly improved on the Adapted Fresno Test after 10-monthly (6.6 points: 95% CI, 0.43 to 12.7) and 16-monthly sessions (7.8 points, 95% CI, 0.85 to 14.7), and on self-reported total EBPQ ratings of confidence at 10-months (4.9 points: 95% CI, 2.2 to 7.5) and 16-months (5.7 points: 95% CI 2.7 to 8.7). Across sessions, 88 AHPs reported adopting new treatments/resources and 64 AHPs reported updating clinical procedures. Mean attendance was 5.7 sessions (SD= 3.8), and average adherence to TREAT components each session was 86% (95% CI, 83 to 89). Most participants recommended the format and reported desire to continue TREAT JCs. Enablers to the JC included using clinically relevant topics and active participation, while reported barriers included limited time to prepare. ConclusionsTREAT JCs can be implemented and sustained by AHPs for 16 monthly-sessions. Participation improved EBP skills and confidence and led to changes in clinical practice. Contextual enablers and barriers should be considered when implementing locally.