bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma
Authors: Nishikawa Masahiro , Inoue Akihiro , Ohnishi Takanori , Yano Hajime , Kanemura Yonehiro , Kohno Shohei , Ohue Shiro , Ozaki Saya , Matsumoto Shirabe , Suehiro Satoshi , Nakamura Yawara , Shigekawa Seiji , Watanabe Hideaki , Kitazawa Riko , Tanaka Junya , Kunieda Takeharu 
Published: February 2021

AbstractAntiangiogenic therapy with bevacizumab (Bev), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is a common treatment for recurrent glioblastoma (GBM), but its survival benefit is limited. Resistance to Bev is thought to be a major cause of ineffectiveness on Bev therapy. To optimize Bev therapy, identification of a predictive biomarker for responsiveness to Bev is required. Based on our previous study, we focused on the expression and functions of CD44 and VEGF in the Bev therapy. Here, we analyze a relationship between CD44 expression and responsiveness to Bev and elucidate the role of CD44 in anti‐VEGF therapy. CD44 and VEGF expression in the tumor core and periphery of 22 GBMs was examined, and the relationship between expression of these molecules and progression‐free time on Bev therapy was analyzed. The degree of CD44 expression in the tumor periphery was evaluated by the ratio of the mRNA expression in the tumor periphery to that in the tumor core (P/C ratio). VEGF expression was evaluated by the amount of the mRNA expression in the tumor periphery. To elucidate the roles of CD44 in the Bev therapy, in vitro and in vivo studies were performed using glioma stem‐like cells (GSCs) and a GSC‐transplanted mouse xenograft model, respectively. GBMs expressing high P/C ratio of CD44 were much more refractory to Bev than those expressing low P/C ratio of CD44, and the survival time of the former was much shorter than that of the latter. In vitro inhibition of VEGF with siRNA or Bev‐activated CD44 expression and increased invasion of GSCs. Bev showed no antitumor effects in mice transplanted with CD44‐overexpressing GSCs. The P/C ratio of CD44 expression may become a useful biomarker predicting responsiveness to Bev in GBM. CD44 reduces the antitumor effect of Bev, resulting in much more highly invasive tumors.
Evaluating a combined intervention targeting at‐risk post‐secondary students: When it comes to graduating, mental health matters
Authors: Antunes‐Alves Sara , Langmuir Tori 
Published: February 2021

AbstractAmid reports of the surging mental health crisis among students, a related area of concern for many post‐secondary institutions is retention rates. Mental distress has been shown to impact academic functioning, leading to decreased academic performance and dropout. This quantitative study evaluated a 12‐week combined counselling intervention programme designed to improve both the mental health and academics of 244 self‐referred, at‐risk students at a Canadian university. Differences pre‐ and post‐programme were examined among the following groups: those who were struggling academically, those who were mentally distressed and those who were experiencing both issues. Mental health, academic functioning and academic performance were measured pre‐ and post‐programme by means of Likert‐style questionnaires and overall grade point average (GPA). Results of paired‐samples t tests demonstrated that all groups experienced significant improvement in academic performance, academic functioning and mental health. Almost all students who presented to the programme on academic warning were able to increase their grades in order to remain in their programmes, avoiding suspension. Findings demonstrate the programme's potential to provide support for university students who are struggling both academically and mentally, as well as increasing student retention rates. Discussion of these results highlights the implications for the implementation of holistic, combined intervention approaches within university policy to increase student retention rates and answer student calls for increased mental health support.
Hirschsprung Disease in an Infant with L1 syndrome: Report of a New Case and a novel L1CAM variant
Authors: Gauntner Timothy D. , Karumuri Manasa , Guzman Miguel A. , Starnes Sara E. , Besmer Sherri , Pinz Hailey , Braddock Stephen R. , Andreone Teresa L. 
Published: February 2021

AbstractL1syndrome is an X‐linked disorder manifesting with congenital hydrocephalus, adducted thumbs and spasticity. There are rare cases of L1 syndrome and coincident Hirschsprung disease, with mutations in the L1CAM gene thought to underlie both. We present a novel pathogenic L1CAM variant in someone with L1 syndrome and Hirschsprung disease.
Phenotypic overlap between pyruvate dehydrogenase complex deficiency and FOXG1 syndrome
Authors: Akaba Yuichi , Takahashi Satoru , Takeguchi Ryo , Tanaka Ryosuke , Nabatame Shin , Saitsu Hirotomo , Matsumoto Naomichi 
Published: February 2021

AbstractPyruvate dehydrogenase complex (PDHC) deficiency is a mitochondrial disorder. We report two cases of PDHC deficiency with clinical symptoms and brain imaging findings reminiscent of FOXG1 syndrome, suggesting a phenotypic overlap of these disorders.
Management considerations for a critically ill 26‐gestational week patient with COVID‐19: A case report
Authors: Khatib Mohamad Y. , Olagundoye Victor O. , Elshafei Moustafa S. , El Khatib Fadi M. , Mohamed Ahmed S. , Nashwan Abdulqadir J. 
Published: February 2021

AbstractPregnant women are potentially more susceptible to respiratory tract infections making them a high‐risk group. We describe the successful management of a 35‐year‐old pregnant woman, G3, P1, with a history of a cesarean section who tested positive for COVID‐19 at 26 weeks and required critical care support.
Industrie 4.0 in der Filtertechnik
Authors: Hensel Heiko 
Published: February 2021

AbstractZur Überwachung des Filtrationsprozesses ist ein modernes, effizientes und umweltfreundliches Filterkonzept entstanden, das reale Bedingungen gläsern darstellt. Die neue Generation der Steuerung /überwachung hilft, Abfälle zu reduzieren und Ausfallzeiten von Anlagen zu minimieren.
Nonparametric manifold learning approach for improved process monitoring
Authors: Cui Ping , Wang Xuhong , Yang Yupu 
Published: February 2021

AbstractA novel nonparametric method based on manifold learning is proposed for industrial process monitoring. In conventional algorithms, to preserve the global and local structure information of data, heat kernels containing two auxiliary parameters are introduced to define the global and local weight matrices, respectively. However, it is difficult to identify and choose these two parameters empirically. The inadequate selection of parameters can lead to one‐sided and inappropriate global and local feature extractions, resulting in an inadequate fault detection performance. To resolve the above problems, a nonparametric strategy is used in this study to generate two nonparametric weight matrices to replace the heat kernel‐based weight matrices. Consequently, the proposed method requires no auxiliary parameters in defining the weight matrices, making it more practical. Moreover, it automatically determines a good trade‐off between global and local feature extractions. A process monitoring model based on the proposed method was developed. The feasibility and effectiveness of the new nonparametric method are evaluated using a synthetic example and the Tennessee Eastman chemical process.
Design, Synthesis and Ring‐Opening Properties of a New Bipyridine Fused Rhodamine‐Like Chelating Ligand and the Related Transition Metal Complexes†
Authors: Qian Zhiyuan , Cheng Yukun , Zhao Shunan , Wong Keith Man‐Chung 
Published: February 2021

Main observation and conclusionA new bipyridine fused rhodamine‐like chelating ligand and the corresponding transition metal complexes of platinum(II) and iridium(III) have been designed, synthesized and structurally characterized by X‐ray crystallography. Their photophysical properties and acid‐ or metal ion‐promoted spirocarbon ring‐opening properties have been investigated. The platinum(II) and iridium(III) complexes show a drastic color change in solution with Hg2+ ions and emergency of an absorption band at around 450—600 nm, assignable to the absorption band of the ring‐opened rhodamine‐like ligand. The platinum(II) complex was suggested to undergo dissociation with Hg2+ ion, based on the corresponding absorption titration study. Emission titration studies of iridium(III) complexes were found to suffer from the quenching process, probably due to the presence of a lower‐lying non‐emissive excited state from the ring‐opened form of ligand.
The effect of smoking, obesity and diabetes on recurrence‐free and overall survival in patients with stage III colon cancer receiving adjuvant chemotherapy
Authors: Croese Alex , Gartrell Richard , Hiscock Richard , Lee Margaret , Gibbs Peter , Faragher Ian , Yeung Justin 
Published: February 2021

AbstractBackgroundThe association between smoking, diabetes and obesity and oncological outcomes in patients with stage III colon cancer treated with surgery and adjuvant chemotherapy is unclear.AimTo evaluate whether smoking, obesity and diabetes are associated with the disease‐free survival and overall survival rates of patients with stage III colon cancer who have received adjuvant chemotherapy.MethodsPatients were selected from the prospectively maintained Australian Cancer Outcomes and Research Database (ACCORD). All stage III colon cancer patients who received adjuvant chemotherapy between January 2003 to December 2015 were retrospectively analyzed. The three primary exposures of interest were smoking status, body mass index (BMI) and diabetic (DM) status. The primary outcomes of interest were disease‐free survival (DFS) and overall survival (OS).ResultsA total of 785 patients between 2003 and 2015 were included for analysis. Using Kaplan‐Meier survivorship curves, there was no association between OS and smoking (P = .71), BMI (P = .3) or DM (P = .72). Similarly, DFS did not reveal an association with smoking (P = .34), BMI (P = .2) and DM (P = .34). Controlling for other covariates the results did not reach statistical significance in adjusted multiple regression models.ConclusionSmoking, obesity and DM were not shown to influence DFS or OS for patients with stage III colon cancer who have received adjuvant chemotherapy.
Trusted data collection for Internet of Things
Authors: Ning Zhenhu , Gong Bei , Xu Meng , Zhou Caiqiu 
Published: February 2021

SummaryTrusted date collection is the precondition of the security of Internet of Things (IOT). Recently, compressed sensing technology, which can enable the reduction of the energy consumption and time delay of data collection, has been extensively studied in IOT; However, the security of compressed sensing technology in IOT has not been sufficiently considered. Since compressed sensing depends the cooperation between IOT nodes and then sensing data is transparent for all IOT nodes, which is subjected to malicious nodes attack. Therefore, we propose a trusted data collection scheme based on compressed sensing oriented to the IOT. When data collection is tampered with, the scheme can detect malicious nodes. Experiments demonstrate that the proposed scheme can ensure data security with a low energy consumption.
Evaluation of Meropenem‐Ciprofloxacin Combination Dosage Regimens for the Pharmacokinetics of Critically Ill Patients With Augmented Renal Clearance
Authors: Agyeman Akosua A. , Rogers Kate E. , Tait Jessica R. , Bergen Phillip J. , Kirkpatrick Carl M. , Wallis Steven C. , Bulitta Jürgen B. , Paterson David L. , Lipman Jeffrey , Nation Roger L. , Roberts Jason A. , Landersdorfer Cornelia B. 
Published: February 2021

Augmented renal clearance (ARC, creatinine clearance > 130 mL/minute) makes difficult achievement of effective concentrations of renally cleared antibiotics in critically ill patients. This study examined the synergistic killing and resistance suppression for meropenem‐ciprofloxacin combination dosage regimens against Pseudomonas aeruginosa isolates within the context of ARC. Clinically relevant meropenem and ciprofloxacin concentrations, alone and in combinations, were studied against three clinical isolates with a range of susceptibilities to each of the antibiotics. Isolate Pa1280 was susceptible to both meropenem and ciprofloxacin, Pa1284 had intermediate susceptibility to meropenem and was susceptible to ciprofloxacin, and CR380 was resistant to meropenem and had intermediate susceptibility to ciprofloxacin. Initially, isolates were studied in 72‐hour static‐concentration time‐kill (SCTK) studies. Subsequently, the pharmacokinetic profiles expected in patients with ARC receiving dosage regimens, including at the highest approved daily doses (meropenem 6 g daily divided and administered as 0.5‐hour infusions every 8 hours, or as a continuous infusion; ciprofloxacin 0.4 g as 1‐hour infusions every 8 hours), were examined in a dynamic hollow‐fiber infection model (HFIM) over 7–10 days. In both SCTK and HFIM, combination regimens were generally synergistic and suppressed growth of less‐susceptible subpopulations, these effects being smaller for isolate CR380. The time‐courses of total and less‐susceptible bacterial populations in the HFIM were well‐described by mechanism‐based models, which enabled conduct of Monte Carlo simulations to predict likely effectiveness of approved dosage regimens at different creatinine clearances. Optimized meropenem‐ciprofloxacin combination dosage regimens may be a viable consideration for P. aeruginosa infections in critically ill patients with ARC.
Self‐Assembly Method for Insensitive DAAF/FOX‐7 Composite Crystals with Microspheres Structure
Authors: Liu Shujie , Wu Bidong , Xie Jiani , Li Zhimin , An Chongwei , Wang Jingyu , Li Xiaodong 
Published: February 2021

AbstractHighly efficient design for the formulation of explosives is desired for accelerating the development of energetic materials. These investigations are focused on the preparation of the compounds 3,3′‐diamino‐4,4′‐azoxyfurazan (DAAF) and 1,1‐diamino‐2,2‐dinitroethylene (FOX‐7). DAAF/FOX‐7 microspheres are prepared via the self‐assembly method using different mass ratios of DAAF and FOX‐7. Materials Studio is used to analyze the intermolecular binding energy (Ebind) of the composite system. DAAF/FOX‐7 with a mass ratio of 90:10 shows a higher Ebind (183.24 kJ mol−1) and peak temperature at the heating rate of 0 °C min−1 (266.2 °C) than DAAF/FOX‐7 with a mass ratio of 70:30 and DAAF/FOX‐7 with a mass ratio of 80:20; this indicates that DAAF/FOX‐7 (90:10) shows better thermal stability. EXPLO5 is used to analyze the detonation velocity of the composite system, and the detonation velocity of DAAF/FOX‐7 microspheres increase by 0.5 km s−1 compared to that of DAAF. The characteristic drop height of impact sensitivity is more than 100 cm, and this demonstrates that the microspheres exhibit good safety performance. The morphology, crystal structure, thermal decomposition property, and impact sensitivity of the microspheres are investigated and compared. X‐ray diffraction and Fourier transform infrared spectroscopy results indicate that the structure of the DAAF/FOX‐7 composite is not changed compared to that of the raw material.
A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression
Authors: He Yuan , Kan Weiqiong , Li Yunqi , Hao Yun , Huang Anling , Gu Haijun , Wang Minna , Wang Qingqing , Chen Jinlian , Sun Zhenliang , Liu Mingyao , Chen Yihua , Yi Zhengfang 
Published: February 2021

AbstractAs a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored. In the present study, we provided the first functional evidence that MYOF promoted the cell invasion of colorectal cancer. Furthermore, we identified a novel small molecule inhibitor of MYOF (named YQ456) that showed high binding affinity to MYOF (KD = 37 nM) and excellent anti‐invasion capability (IC50 = 110 nM). YQ456 was reported for the first time to interfere with the interactions between MYOF and Ras‐associated binding (Rab) proteins at low nanomolar levels. This interference disrupted several vesicle trafficking processes, including lysosomal degradation, exosome secretion, and mitochondrial dynamics. Further, YQ456 exhibited excellent inhibitory effects on the growth and invasiveness of colorectal cancer. As the first attempt, the anticancer efficacy of YQ456 in the patient‐derived xenograft (PDX) mouse model indicated that targeting MYOF may serve as a novel and practical therapeutic approach for colorectal cancer.
Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy
Authors: Casagrande Viviana , Iuliani Giulia , Menini Stefano , Pugliese Giuseppe , Federici Massimo , Menghini Rossella 
Published: February 2021

AbstractBackgroundDiabetic nephropathy (DN), one of the major complications of diabetes, is characterized by albuminuria, glomerulosclerosis, and progressive loss of renal function. Loss of TIMP3, an Extracellular Matrix bound protein affecting both inflammation and fibrosis, is a hallmark of DN in human subjects and mouse models.MethodsThis study was designed to provide evidences that the modulation of the system involving TIMP3 and its target A Disintegrin And Metalloproteinase 17 (ADAM17), may rescue kidney pathology in diabetic mice. Mice with cell‐targeted overexpression of TIMP3 in myeloid cells (MacT3), podocyte‐specific ADAM17 knockout mice (∆PodA17), and DBA/2J mice, were rendered diabetic at 8 weeks of age with a low‐dose streptozotocin protocol. DBA/2J mice were administered new peptides based on the human TIMP3 N‐terminal domain, specifically conjugated with G3C12, a carrier peptide highly selective and efficient for transport to the kidney. Twelve weeks after Streptozotocin injections, 24‐hour albuminuria was determined by ELISA, kidney morphometry was analyzed by periodic acid‐shift staining, and Real Time‐PCR and western blot analysis were performed on mRNA and protein extracted from kidney cortex.ResultsOur results showed that both genetic modifications and peptides treatment positively affect renal function and structure in diabetic mice, as indicated by a significant and consistent decline in albuminuria along with reduction in glomerular lesions, as indicated by reduced mesangial expansion and glomerular hypertrophy, decreased deposition of extracellular matrix in the mesangium, diminished protein expression of the NADPH oxidases 4 (NOX4), and the improvement of podocyte structural markers such as WT1, nephrin, and podocin. Moreover, the positive effects were exerted through a mechanism independent from glycemic control.ConclusionsIn diabetic mice the targeting of TIMP3 system improved kidney structure and function, representing a valid approach to develop new avenues to treat this severe complication of diabetes.
Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays
Authors: Keshavan Ashvini , Wellington Henrietta , Chen Zhongbo , Khatun Ayesha , Chapman Miles , Hart Melanie , Cash David M. , Coath William , Parker Thomas D. , Buchanan Sarah M. , Keuss Sarah E. , Harris Matthew J. , Murray‐Smith Heidi , Heslegrave Amanda , Fox Nick C. , Zetterberg Henrik , Schott Jonathan M 
Published: February 2021

AbstractINTRODUCTIONWe assessed the concordance of cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau measured on the fully automated Lumipulse platform with pre‐symptomatic Alzheimer's disease (AD) pathology on amyloid positron emission tomography (PET).METHODSIn 72 individuals from the Insight 46 study, CSF Aβ40, Aβ42, total tau (t‐tau), and phosphorylated tau at site 181 (p‐tau181) were measured using Lumipulse, INNOTEST, and Meso Scale Discovery (MSD) assays and inter‐platform Pearson correlations derived. Lumipulse Aβ42 measures were adjusted to incorporate standardization to certified reference materials. Logistic regressions and receiver operating characteristics analysis generated CSF cut‐points optimizing concordance with 18F‐florbetapir amyloid PET status (n = 63).RESULTSMeasurements of CSF Aβ, p‐tau181, and their ratios correlated well across platforms (r 0.84 to 0.94, P < .0001); those of t‐tau and t‐tau/Aβ42 correlated moderately (r 0.57 to 0.79, P < .0001). The best concordance with amyloid PET (100% sensitivity and 94% specificity) was afforded by cut‐points of 0.075 for Lumipulse Aβ42/Aβ40, 0.087 for MSD Aβ42/Aβ40 and 17.3 for Lumipulse Aβ42/p‐tau181.DISCUSSIONThe Lumipulse platform provides comparable sensitivity and specificity to established CSF immunoassays in identifying pre‐symptomatic AD pathology.
Cervical cancer: Automation of Pap test screening
Authors: Rezende Mariana T. , Bianchi Andrea G. C. , Carneiro Cláudia M. 
Published: February 2021

AbstractBackgroundCervical cancer progresses slowly, increasing the chance of early detection of pre‐neoplastic lesions via Pap exam test and subsequently preventing deaths. However, the exam presents both false‐negatives and false‐positives results. Therefore, automatic methods (AMs) of reading the Pap test have been used to improve the quality control of the exam. We performed a literature review to evaluate the feasibility of implementing AMs in laboratories.MethodsThis work reviewed scientific publications regarding automated cytology from the last 15 years. The terms used were “Papanicolaou test” and “Automated cytology screening” in Portuguese, English, and Spanish, in the three scientific databases (SCIELO, PUBMED, MEDLINE).ResultsOf the resulting 787 articles, 34 were selected for a complete review, including three AMs: ThinPrep Imaging System, FocalPoint GS Imaging System and CytoProcessor. In total, 1 317 148 cytopathological slides were evaluated automatically, with 1 308 028 (99.3%) liquid‐based cytology slides and 9120 (0.7%) conventional cytology smears. The AM diagnostic performances were statistically equal to or better than those of the manual method. AM use increased the detection of cellular abnormalities and reduced false‐negatives. The average sample rejection rate was ≤3.5%.ConclusionAMs are relevant in quality control during the analytical phase of cervical cancer screening. This technology eliminates slide‐handling steps and reduces the sample space, allowing professionals to focus on diagnostic interpretation while maintaining high‐level care, which can reduce false‐negatives. Further studies with conventional cytology are needed. The use of AM is still not so widespread in cytopathology laboratories.