bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin
Authors: Burke Ryan M. , Dirkx Ronald A. , Quijada Pearl , Lighthouse Janet K. , Mohan Amy , O’Brien Meghann , Wojciechowski Wojciech , Woeller Collynn F. , Phipps Richard P. , Alexis Jeffrey D. , Ashton John M. , Small Eric M. 
Published: April 2021

Rationale:
Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts called myofibroblasts. There are currently no therapeutic approaches to blunt the development of pathological fibrosis and ventricle chamber stiffening that ultimately leads to heart failure.

Objective:
We undertook a high-throughput screen to identify small molecule inhibitors of myofibroblast activation that might limit the progression of heart failure. We evaluated the therapeutic efficacy of the polyether ionophore salinomycin in patient-derived cardiac fibroblasts and preclinical mouse models of ischemic and nonischemic heart failure.

Methods and Results:
Here, we demonstrate that salinomycin displays potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In preclinical studies, salinomycin prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease. Remarkably, interventional treatment with salinomycin attenuates preestablished pathological cardiac remodeling secondary to hypertension and limits scar expansion when administered after a severe myocardial infarction. Mechanistically, salinomycin inhibits cardiac fibroblast activation by preventing p38/MAPK (mitogen activated protein kinase) and Rho signaling. Salinomycin also promotes cardiomyocyte survival and improves coronary vessel density, suggesting that cardioprotection conferred by salinomycin occurs via the integration of multiple mechanisms in multiple relevant cardiac cell types.

Conclusions:
These data establish salinomycin as an antifibrotic agent that targets multiple cardioprotection pathways, thereby holding promise for the treatment of heart failure patients.
Morphological and molecular characteristics of Bastiania sinensis sp. n., Tripyla aquatica Brzeski & Winiszewska-Ślipińska, 1993 and T. setifera Bütschli, 1873 (Nematoda: Triplonchida) from Shanxi Province, North China
Authors: Liu Mei Na , Xu Yu Mei , Zhao Zeng Qi , Wang Jian Ming 
Published: April 2021

Summary
This paper describes a new species of Bastiania, presents a new record and redescribes a known species of Tripyla. These nematodes are all in the order Triplonchida and were collected from Shanxi Province, North China. Bastiania sinensis sp. n. is characterised by having the female with a relatively slender body 1049-1295 μm long, dorsally arcuate after heat relaxation, with outer labial setae and cephalic setae in a single circle, an oval amphid, 7-8 laterodorsal cervical setae scattered in the pharyngeal region, orthometamenes and pseudocoelomocytes present, tail conoid with a mucron 1-2 μm long, two pairs of caudal setae present, a = 58.1-75.5, b = 4.0-4.6, c = 12.7-19.7, c′ = 4.1-7.8 and V = 61.1-67.7. Males were not found. Tripyla aquatica is recorded for the first time from China, and is redescribed. Tripyla setifera has been reported from China but without a detailed description – now provided. In addition, phylogenetic relationships among the species were analysed using data from the near full length small subunit (SSU) and D2-D3 segments of large subunit (LSU) of rRNA genes. Bastiania sinensis sp. n. is monophyletic with the Bastiania sequences available in GenBank, but is on an independent branch supporting its status as a separate species; T. aquatica and T. setifera are monophyletically clustered with known Tripyla species and grouped together with sequences from their respective species.
Is Computational Oceanography Coming of Age?
Authors: Haine Thomas W. N. , Gelderloos Renske , Jimenez-Urias Miguel A. , Siddiqui Ali H. , Lemson Gerard , Medvedev Dimitri , Szalay Alex , Abernathey Ryan P. , Almansi Mattia , Hill Christopher N. 
Published: April 2021

AbstractComputational oceanography is the study of ocean phenomena by numerical simulation, especially dynamical and physical phenomena. Progress in information technology has driven exponential growth in the number of global ocean observations and the fidelity of numerical simulations of the ocean in the past few decades. The growth has been exponentially faster for ocean simulations, however. We argue that this faster growth is shifting the importance of field measurements and numerical simulations for oceanographic research. It is leading to the maturation of computational oceanography as a branch of marine science on par with observational oceanography. One implication is that ultraresolved ocean simulations are only loosely constrained by observations. Another implication is that barriers to analyzing the output of such simulations should be removed. Although some specific limits and challenges exist, many opportunities are identified for the future of computational oceanography. Most important is the prospect of hybrid computational and observational approaches to advance understanding of the ocean.
AMOC stability and diverging response to Arctic sea ice decline in two climate models
Authors: Li Hui , Fedorov Alexey , Liu Wei 
Published: April 2021

AbstractThis study compares the impacts of Arctic sea ice decline on the Atlantic Meridional Overturning Circulation (AMOC) in two configurations of the Community Earth System Model (CESM) with different horizontal resolution. In a suite of model experiments we impose radiative imbalance at the ice surface, replicating a loss of sea ice cover comparable to the observed during 1979-2014, and find dramatic differences in the AMOC response between the two models. In the lower-resolution configuration, the AMOC weakens by about one third over the first 100 years, approaching a new quasi-equilibrium. By contrast, in the higher-resolution configuration, the AMOC weakens by ~10% during the first 20-30 years followed by a full recovery driven by invigorated deep water formation in the Labrador Sea and adjacent regions. We investigate these differences using a diagnostic AMOC stability indicator, which reflects the AMOC freshwater transport in and out of the basin and hence the strength of the basin-scale salt-advection feedback. This indicator suggests that the AMOC in the lower-resolution model is less stable and more sensitive to surface perturbations, as confirmed by hosing experiments mimicking Arctic freshening due to sea ice decline. Differences between the models’ mean states, including the Atlantic mean surface freshwater fluxes, control the differences in AMOC stability. Our results demonstrate that the AMOC stability indicator is indeed useful for evaluating AMOC sensitivity to perturbations. Finally, we emphasize that, despite the differences in the long-term adjustment, both models simulate a multi-decadal AMOC weakening caused by Arctic sea ice decline, relevant to climate change.
Endaural Over-Underlay Cartilage Tympanoplasty for Repair of Dry Subtotal Perforations
Authors: Çetin Yaser Said , Erdem Mehmet Zeki 
Published: April 2021

Objectives: We explored the auditory and anatomical success of grafting when the cartilage perichondrium (CP) was prepared using two different methods. Methods: Patients with subtotal or total perforation underwent tympanoplasty with a CP graft. A V-shaped groove for the handle of the malleus was prepared for CP grafts in patients in group 1. Patients in group 2 did not have a groove on the graft. The anatomical success of the graft was evaluated as success, partial success, or failure. Results of auditory evaluations were compared between the two groups. Results: A total of 195 patients were included in the study. The total CP graft integration rate was 96% for both groups. Significant changes were detected in all hearing criteria evaluated 12 months after surgery compared to the preoperative period ( P < .05). There were no significant differences between the groups in terms of the relationship between graft technique and postoperative hearing results. However, rates of partial success were significantly higher for group 1 than group 2 ( P = .033). Conclusion: Cartilage slice support offers an extremely reliable method for reconstruction of tympanic membrane in cases of high-risk perforation. Partial failures are rare, but when they occur, they most often involved anterior graft medialization. When a piece of cartilage is removed at the malleus interface there may be a higher rate of partial failure.
Positioning Practices of Orientation and Mobility Specialists When Teaching Street Crossings: Is There a Standard Approach?
Authors: Zebehazy Kim T. , Renshaw Rebecca L. , Zimmerman George J. 
Published: April 2021

Introduction: An important skill for orientation and mobility (O&M) specialists to have is to monitor clients appropriately when they are learning to cross intersections. Techniques books provide some suggestions for positioning during street crossings, but no research has been conducted about consensus or priorities for making appropriate decisions on positioning. The purpose of this study was to investigate general positioning decisions using visual monitoring techniques. Method: A total of 234 participants (practicing O&M specialists, preservice O&M students, and O&M university personnel) completed a 40-question survey. The survey included demographic questions, diagrams of intersections that participants used to select positioning locations, questions about lanes of threat, and questions about important factors to consider when positioning to monitor safety. Commonality of selections were analyzed and compared with demographic information. Results: The greatest consensus was found for all intersection types when the client is positioned on the corner waiting to cross and for identification of the first lane of threat. More variable position selections were made for monitoring during the crossings, and the second and third lane of threat selections were also more variable. Factors respondents indicated as most important to consider when positioning aligned with their positioning choices overall. Discussion: Personnel preparation programs may want to consider to what extent they teach considerations for positioning before and during crossings, and whether the predominant tendency to put oneself between the client and traffic warrants additional conversation. Future research should look at more complex intersections and the additional nuances used to make positioning choices. Implications for practitioners: Practitioners should reflect on whether they actively change their positioning decisions based on the situation and type of intersection versus tending to use a standard strategy.
Assessing the Longitudinal Change in Low Vision: A Test of Competing Hypotheses
Authors: Liew Hui-Peng 
Published: April 2021

Introduction: Visual impairment among older adults has increasingly become one of the biggest challenges to public health and personal well-being in the United States. This study aims to examine whether the intersectionality hypothesis can be used in conjunction with the cumulative advantage (disadvantage), persistent inequality, or age-as-leveler to explain heterogeneity in low vision trajectories across birth cohorts, race or ethnicity, gender, and the level of education. Methods: Growth curve modeling was used to analyze data from the 2002–2014 Health and Retirement Study. Results: The type of trajectory (i.e., cumulative advantage or disadvantage, the persistent inequality, and the age-as-leveler) that characterize low vision is largely dependent upon the characteristics of an individual (i.e., race or ethnicity, gender, and education). Discussion: Trajectories of low vision are higher among females and those from ethnic minority groups with low levels of education. Implications for practitioners: Targeted interventions and attempts to close interethnic disparities in vision functioning should begin early on in life and should focus on racial ethnic minorities, females, and those with low education.
Stimulus Generalization Using Nonvisual Stimuli with a Student Who Has Autism Spectrum Disorder and Visual Impairment
Authors: Arnall Robin , Garcia Yors , Griffith Annette K. , Spear Jack 
Published: April 2021

Introduction: The main objective of this study was to determine whether stimulus symmetry, or untaught generalized relations among stimuli, could be demonstrated using audio and tactile stimuli (i.e., nonvisual). Methods: A modified alternating treatment within a concurrent multiple baseline design across nonvisual stimulus sets (i.e., tactile and audio) was implemented with Zach, an 11-year-old male diagnosed with autism and visual impairment, to teach two relations (sound–touch and sound–label) among stimuli. Following training, the researcher tested whether Zach could identify stimuli through an untaught relation (touch–label). The study presented here required a week to complete and was conducted at a private school for individuals with behavioral concerns. Results: During baseline, Zach demonstrated low levels of correct responses (average of 7% across all relations) for all skills. In the training phase (for only two of the three targeted skills, sound–touch and sound–label relations), Zach demonstrated proficiency for most stimuli used in the sets (average of 61% across relations). Finally, in the testing phase (the untaught touch–label relation), Zach demonstrated high levels of generalized acquisition (89%). Discussion: Results indicated that the procedure used in this study could be generalized to novel populations, including those with visual impairments, and that different forms of sensory input could be used, including auditory and tactile-based teaching. Implications for practitioners: Individuals working with learners with differing levels of visual impairment could utilize the demonstrated procedure to associate types of stimuli, using methods other than visual input. The procedure outlined would benefit a population that may require assistance with developing language skills but who also may have difficulties using common visual stimuli.
Coronary endarterectomy in coronary artery disease: Factors affecting graft patency and survival
Authors: Chow Simon CY , Ho Jacky YK , Kwok Micky WT , Fujikawa Takuya , Lim Kevin , Wan Song , Wong Randolph HL 
Published: April 2021

Background Coronary endarterectomy aims to improve completeness of revascularization in patients with occluded coronary vessels. The benefits of coronary endarterectomy remain uncertain. The aim of this study was to evaluate short-term surgical outcomes and factors affecting graft patency post-coronary endarterectomy. Methods Between 2009 and 2019, 81 consecutive patients who had coronary endarterectomy done were evaluated for their perioperative and early results. A total of 36 patients with follow-up coronary studies were included in patency analysis. Mortality rates, major adverse cardiac and cerebrovascular events, and graft patency were outcomes of interest. Survival and risk factor analysis were performed with Kaplan–Meier and logistic regression analysis. Results The average age of the cohort was 61.9 ± 9.29 years. Complete revascularization rate was 95.4% post-coronary endarterectomy. The 30-day and 1-year mortality was 2.5 and 6.2%, respectively. One-year major adverse cardiac and cerebrovascular events rate was 11.1%. Periprocedural myocardial infarction rate was 7.4%. Three patients required repeat revascularization within a mean follow-up duration of 49.6 ± 36.5 months. Overall graft patency was 89.2% at 20.2 months and graft patency post-coronary endarterectomy was 85.4%. Arterial grafts showed 100% patency. Vein grafts to endarterectomized obtuse marginal branch had patency rates of 33.3%. Multiple endarterectomies were associated with worse one-year major adverse cardiac and cerebrovascular events (OR: 28.6 ± 1.16; P = 0.003). Conclusions Coronary endarterectomy facilitates completeness of revascularization and does not increase early mortality. Graft patency post-coronary endarterectomy on obtuse marginal artery was suboptimal. Judicious use of coronary endarterectomy should be practiced to balance the need of completeness of revascularization against the risk of myocardial infarction.
Built Environment and HIV Linkage to Care in Rural South Africa
Authors: Shangase Nosipho , Pence Brian , Lippman Sheri A. , Dufour Mi-Suk Kang , Kabudula Chodziwadziwa Whiteson , Gómez-Olivé F. Xavier , Kahn Kathleen , Pettifor Audrey 
Published: April 2021

Background We assessed built environment (residential density, landuse mix and aesthetics) and HIV linkage to care (LTC) among 1,681 (18–49 years-old) residents of 15 Mpumalanga villages, South Africa. Methods Multilevel models (linear-binomial) were used for the association between built environment, measured using NEWS for Africa, and LTC from a clinical database of 9 facilities (2015–2018). Additionally, we assessed effect-measure modification by universal test-and-treat policy (UTT). Results We observed, a significant association in the adjusted 3-month probability of LTC for residential density (risk difference (RD)%: 5.6, 95%CI: 1.2–10.1), however, no association for land-use mix (RD%: 2.4, 95%CI: −0.4, 5.2) and aesthetics (RD%: −1.2, 95%CI: −4.5–2.2). Among those diagnosed after UTT, residents of high land-use villages were more likely to link-to-care than those of low land-use villages at 12 months (RD%: 4.6, 95%CI: 1.1–8.1, p < 0.04), however, not at 3 months (RD%: 3.0, 95%CI: −2.1–8.0, p > 0.10). Conclusion Findings suggest, better built environment conditions (adequate infrastructure, proximity to services etc.) help facilitate LTC. Moreover, UTT appears to have a protective effect on LTC.
Prognosis of C4 dislocation with spinal cord injury following psychological intervention
Authors: Zhao Min-Chao , Yang Kai , Yang Bao-Hui , Guo Shuai , Wang Ya-Ping , Zhang Xiao-Wei , Li Hao-Peng 
Published: April 2021

Objective To investigate the effect of psychological intervention on the prognosis of patients with C4 dislocation and spinal cord injury. Methods We investigated target patients admitted between 2010 and 2018. Patients’ mental state, quality of life and neurological function at different time points were evaluated to examine the relationship between psychological intervention and recovery and prognosis of acute and critical spinal cord injury. Results All patients showed improvements in clinical symptoms, neurological function and quality of life. Psychological intervention significantly improved Zung Self-Rating Anxiety Scale score, Zung Self-Rating Depression Scale score and SF-36 Mental Component Summary score within 3 months. Japanese Orthopaedic Association neurological function score and SF-36 Physical Component Summary score were significantly improved after 1-year follow-up. Psychological intervention did not improve 2-year survival. Conclusion Timely and professional psychological intervention can eliminate the psychological disorders of C4 dislocation patients with spinal cord injury. This has a positive effect on their quality of life and prognosis.
Clinical importance of the distribution of pulmonary artery embolism in acute pulmonary embolism
Authors: Nie Yunqiang , Sun Li , Long Wei , LV Xin , Li Cuiyun , Wang Hui , Li Xing , Han Ping , Guo Miao 
Published: April 2021

Objective To explore the clinical importance of the distribution of pulmonary artery embolism in acute pulmonary embolism (APE). Methods Sixty-four patients with APE were classified into mixed-type and distal-type pulmonary embolism groups. Their right ventricular systolic pressure (RVSP) and disease duration were recorded, and the diameter of their right ventricles was measured by ultrasound. The computed tomography angiographic clot load was determined as a Mastora score. Results Patients with distal-type pulmonary embolisms had significantly lower RVSPs (44.92 ± 17.04 vs 55.69 ± 17.66 mmHg), and significantly smaller right ventricular diameters (21.08 ± 3.06 vs 23.37 ± 3.48 mm) than those with mixed-type pulmonary embolisms. Additionally, disease duration was significantly longer in patients with distal-type pulmonary embolisms (14.33 ± 11.57 vs 8.10 ± 7.10 days), and they had significantly lower Mastora scores (20.91% ± 18.92% vs 43.96% ± 18.30%) than patients with mixed-type pulmonary embolisms. After treatment, RVSPs decreased significantly in patients with both distal-type and mixed-type pulmonary embolisms. Right ventricle diameters also decreased significantly in patients with mixed-type pulmonary embolisms after treatment. Conclusion Patients with mixed-type pulmonary embolisms are significantly more susceptible to pulmonary hypertension, enlarged right ventricular diameters, and shorter durations of disease than those with distal-type pulmonary embolisms. The distribution of pulmonary artery embolism in APE can provide a clinical reference.
Unleashing the potential of relational research: A meta-analysis of network studies in human geography
Authors: Glückler Johannes , Panitz Robert 
Published: April 2021

Social network analysis has become a popular methodology in human geography. This article develops three propositions – connectivity, contextuality, and reflexivity – for relational analysis to overcome the dualism between universalist network science on the one hand and idiosyncratic network stories on the other. Building on a detailed meta-analysis of over 300 network studies published between 1990 and 2018, we offer a sympathetic critique of the actual use of network methods in human geography. To unleash further potential of network research, we propose several research strategies for more inclusive relational analysis, including informed pre-specification, triangulation, and communicative validation.
A novel phenomenological constitutive model for Ti-6Al-4V at high temperature conditions and quasi-static strain rates
Authors: Ashrafian Mohammad Mahdi , Hosseini Kordkheili Seyed Ali 
Published: April 2021

Phenomenological constitutive modeling of Ti-6Al-4V at temperatures between 923 and 1023 K under 0.0005–0.05 s−1 quasi-static rates is studied based on a phenomenological approach. For this purpose, the Johnson–Cook constitutive model is revisited. At low temperature conditions under moderate to high strain rates, the material’s stress–strain curves are the most similar to power-law function. Contrary to this, at high temperature conditions under low to moderate strain rates, the saturation-type function well describes the stress–strain curves. On the other hand, it is illustrated that the Johnson–Cook constitutive model is feeble to predict the material’s behavior correctly. Accordingly, in this study, a viscoplastic temperature-dependent constitutive model is developed. The strain rate hardening as well as thermal softening of the developed model is the same as the Johnson–Cook model. But a temperature-dependent strain hardening function is proposed in which both the saturation-type and power-law hardening behaviors of the material are implemented. In comparison with the Johnson–Cook model, the new constitutive model’s fidelity in capturing the titanium behavior is depicted. At last, by considering an Arrhenius-type phenomenological constitutive model, it is noted that the developed constitutive model has the best correctness in predicting the Ti-6Al-4V stress–strain behavior at high temperature conditions under quasi-static rates.