bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polygenic heterogeneity across obsessive-compulsive disorder subgroups defined by a comorbid diagnosis
Authors: Strom Nora I. , Grove Jakob , Meier Sandra M. , Bækvad-Hansen Marie , Nissen Judith Becker , Als Thomas Damm , Halvorsen Matthew , Nordentoft Merete , Mortensen Preben B. , Hougaard David M. , Werge Thomas , Mors Ole , Børglum Anders D. , Crowley James J. , Bybjerg-Grauholm Jonas , Mattheisen Manuel 
Published: May 2021

ABSTRACTAmong patients with obsessive-compulsive disorder (OCD), 65-85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible genetic heterogeneity of OCD in relation to its comorbid conditions, however, has not yet been exhaustively explored. We used a framework of different approaches to study the genetic relationship of OCD with three commonly observed comorbidities, namely major depressive disorder (MDD), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). First, using publicly available summary statistics from large-scale genome-wide association studies, we compared genetic correlation patterns for OCD, MDD, ADHD, and ASD with 861 somatic and mental health phenotypes. Secondly, we examined how polygenic risk scores (PRS) of eight traits that showed heterogeneous correlation patterns with OCD, MDD, ADHD, and ASD partitioned across comorbid subgroups in OCD using independent unpublished data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH). The comorbid subgroups comprised of patients with only OCD (N = 366), OCD and MDD (N = 1052), OCD and ADHD (N = 443), OCD and ASD (N = 388), and OCD with more than 1 comorbidity (N = 429). We found that PRS of all traits but BMI were significantly associated with OCD across all subgroups (neuroticism: p = 1.19⨯10−32, bipolar disorder: p = 7.51⨯10−8, anorexia nervosa: p = 3.52⨯10−20, age at first birth: p = 9.38⨯10−5, educational attainment: p = 1.56⨯10−4, OCD: p = 1.87⨯10−6, insomnia: p = 2.61⨯10−5, BMI: p = 0.15). For age at first birth, educational attainment, and insomnia PRS estimates significantly differed across comorbid subgroups (p = 2.29⨯10−4, p = 1.63⨯10−4, and p = 0.045 respectively). Especially for anorexia nervosa, age at first birth, educational attainment, insomnia, and neuroticism the correlation patterns that emerged from genetic correlation analysis of OCD, MDD, ADHD, and ASD were mirrored in the PRS associations with the respective comorbid OCD groups. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across OCD comorbid subgroups.
The Neural Determinants of Beauty
Authors: Yang Taoxi , Formuli Arusu , Paolini Marco , Zeki Semir 
Published: May 2021

AbstractWhat are the conditions that determine whether the medial orbito-frontal cortex (mOFC), in which activity correlates with the experience of beauty derived from different sources, becomes co-active with sensory areas of the brain during the experience of sensory beauty? We addressed this question by studying the neural determinants of facial beauty. The perception of faces correlates with activity in a number of brain areas, but only when a face is perceived as beautiful is the mOFC also engaged. The enquiry thus revolved around the question of whether a particular pattern of activity, within or between areas implicated in face perception, emerges when a face is perceived as beautiful, and which determines that there is, as a correlate, activity in mOFC. 17 subjects of both genders viewed and rated facial stimuli according to how beautiful they perceived them to be while the activity in their brains was imaged with functional magnetic resonance imaging. A univariate analysis revealed parametrically scaled activity within several areas in which the strength of activity correlated with the declared intensity of the aesthetic experience of faces; the list included the mOFC and two core areas strongly implicated in the perception of faces - the occipital face area (OFA), fusiform face area (FFA)- and, additionally, the cuneus. Multivariate analyses showed strong patterns of activation in the FFA and the cuneus and weaker patterns in the OFA and the pSTS. It is only when specific patterns emerged in these areas that there was co-activation of the mOFC, in which a strong pattern also emerged during the experience of facial beauty. A psychophysiological interaction analysis with mOFC as the seed area revealed the involvement of the right FFA and the right OFA. We conjecture that these collective patterns of activity constitute the neural basis for the experience of facial beauty, bringing us a step closer to understanding the neural determinants of aesthetic experience.
Developing an integrated framework for optimization of spatial requirements of construction equipment
Authors: Hemalattha S. , Vidjeapriya R. 
Published: May 2021

PurposeThis study aims to develop a framework for optimizing the spatial requirements of the equipment in a construction site using a geographic information system (GIS).Design/methodology/approachAn ongoing construction project, an existing thermal powerplant in India, is considered to be the case study, and the corresponding construction activities were scheduled. The equipment spaces were defined for the scheduled activities in building information modelling (BIM), which was further imported to GIS to define the topology rules, validate and optimize the spatial requirements. The BIM simulates the indoor environment, which includes the actual structure being constructed, and the GIS helps in modelling the outdoor environment, which includes the existing structures, temporary facilitates, topography of the site, etc.; thus, this study incorporates the knowledge of BIM in a geospatial environment to obtain optimized equipment spaces for various activities.FindingsSpace in construction projects is to be considered as a resource as well as a constraint, which is to be modelled and planned according to the requirements. The integration of BIM and GIS for equipment space planning will enable precise identification of the errors in the equipment spaces defined and also result in fewer errors as possible. The integration has also eased the process of assigning the topology rules and validating the same, which otherwise is a tedious process.Originality/valueThe workspace for each activity will include the space of the equipment. But, in most of the previous works of workspace planning, only the labour space is considered, and the conflicts and congestions occurring due to the equipment were neglected. The planning of equipment spaces cannot be done based only on the indoor environment; it has to be carried out by considering the surroundings and topography of the site, which have not been researched extensively despite its importance.
Identification, analysis and improvement of red meat supply chain strategies considering the impact of COVID-19 pandemic: a hybrid SWOT-QSPM approach in an emerging economy
Authors: Riahi Dorcheh Farshid , Razavi Hajiagha Seyed Hossein , Rahbari Misagh , Jafari-Sadeghi Vahid , Amoozad Mahdiraji Hannan 
Published: May 2021

PurposeIn recent years, and especially during the coronavirus disease 2019 (COVID-19) pandemic, the significant role of agriculture, specifically red meat, in household consumption has been increased. On the other hand, the lack of proper policymaking in the production and pricing of red meat and the lack of a comprehensive study on the beef supply chain has led to a reduction in the role of this protein product in the household food basket. Thus, in this research, comprehensive strategic planning considering the effect of the COVID-19 pandemic has been illustrated to overcome the aforementioned problems.Design/methodology/approachTo study the intended objectives, first, using qualitative methods, the strengths, weaknesses, opportunities and threats (SWOT) to the studied company's supply chain in Iran were identified and then using the SWOT-Quantitative Strategic Planning Matrix (QSPM) technique, the surrounding strategies have been analysed.FindingsThe results indicate that the most important strength of the studied company is the “access to the red meat market of the retirement plan”; the most important weakness is the “lack of required and on-time funding, especially in the condition of the COVID-19 pandemic”; the highest-ranked opportunity is the “access to banking facilities” and the main threat to the company is the “COVID-19 pandemic limitations and health protocols”. In the same vein, by examining the attractiveness score of internal and external factors, it was observed that diversity and competitive strategies would have a higher priority. Finally, the QSPM illustrated that activating the full capacity of existing infrastructure has the highest priority.Originality/valueAccording to the red meat supply chain and the link amongst different market levels, identifying, analysing and improving the beef supply chain is of particular importance. One of the threats facing the international community is the emergence of events such as the COVID-19 pandemic, which requires businesses to choose the right strategy to deal with the issue. Therefore, the main distinction of this study is to identify, analyse and improve the red meat supply chain of a real case due to the condition of the COVID-19 pandemic.
An inverse problem of determining the time-dependent potential in a higher-order Boussinesq-Love equation from boundary data
Authors: Huntul M.J. , Tamsir Mohammad , Ahmadini Abdullah 
Published: May 2021

PurposeThe paper aims to numerically solve the inverse problem of determining the time-dependent potential coefficient along with the temperature in a higher-order Boussinesq-Love equation (BLE) with initial and Neumann boundary conditions supplemented by boundary data, for the first time.Design/methodology/approachFrom the literature, the authors already know that this inverse problem has a unique solution. However, the problem is still ill-posed by being unstable to noise in the input data. For the numerical realization, the authors apply the generalized finite difference method (GFDM) for solving the BLE along with the Tikhonov regularization to find stable and accurate numerical solutions. The regularized nonlinear minimization is performed using the MATLAB subroutine lsqnonlin. The stability analysis of solution of the BLE is proved using the von Neumann method.FindingsThe present numerical results demonstrate that obtained solutions are stable and accurate.Practical implicationsSince noisy data are inverted, the study models real situations in which practical measurements are inherently contaminated with noise.Originality/valueThe knowledge of this physical property coefficient is very important in various areas of human activity such as seismology, mineral exploration, biology, medicine, quality control of industrial products, etc. The originality lies in the insight gained by performing the numerical simulations of inversion to find the potential co-efficient on time in the BLE from noisy measurement.
Macro autonomous traffic flow model with traffic jerk and downstream vehicle information
Authors: Cong Zhai , Wu Weitiao 
Published: May 2021

PurposeIn the era of connected and autonomous vehicles, a large amount of surrounding vehicular information can be acquired by the focal vehicle in real time using vehicle-to-vehicle communication technology, such as the core variable of electronic throttle opening angle. Meanwhile, the traffic jerk, such as the non-compliance of drivers and pedestrians, worsens the chaos of the surrounding traffic environment. To reflect the future traffic environment, the authors simultaneously incorporate the electronic throttle (ET) and traffic jerk into the traditional continuum model. The authors derive the stability criterion of the enhanced continuum model via the perturbation method.Design/methodology/approachTo facilitate insight into the propagation and evolution mechanism of traffic jam near the stability condition, the authors use the nonlinear stability analysis method to derive the KdV-Burgers equation of proposed continuum model.FindingsThe new item of ET opening angle and traffic jerk have a positive impact on suppressing traffic congestion and improving road robustness.Originality/valueThe research on autonomous continuum models is rare. This model can better reflect the actual traffic, which can also provide a theoretical reference for the future traffic governance.
An IoT device for striking of vertical concrete formwork
Authors: John Shemin T. , Mohan Athul , Philip Merin Susan , Sarkar Pradip , Davis Robin 
Published: May 2021

PurposeTimely removal of formwork is one of the crucial aspects of construction management that directly influences the safety and quality of the structure as well as the economy of the project. Code recommendations in this regard are not widely practiced because of the difficulties in their implementations. Also, such code recommendations are not robust for all the possible construction conditions. The present paper proposes an IoT-enabled system that notifies the minimum striking time of vertical formwork based on a specified target compressive strength.Design/methodology/approachAn IoT device is proposed for the timely removal of vertical formwork by monitoring of early age concrete compressive strength in real-time. The maturity method is utilized for this purpose. The implementation of the proposed system is demonstrated on three concrete columns. The proposed system is found to be suitable for any construction condition.FindingsThe proposed system is a novel, cost-effective, IoT-enabled real-time monitoring system which includes features like cloud connectivity and remote monitoring. This system can be easily implemented at the site without any human intervention.Practical implicationsThe study explores the development of an IoT device for the timely removal of vertical formwork which will ensure quality, safety and productivity in concrete construction.Originality/valueThis paper is the first attempt to determine the minimum striking time of vertical formwork using IoT-based technology.
Culture and financial reporting quality in GCC countries: what do we know about tribal culture?
Authors: Baatwah Saeed Rabea , Aljaaidi Khaled Salmen , Almoataz Ehsan Saleh , Salleh Zalailah 
Published: May 2021

PurposeAlthough the effect of culture on financial reporting practices has been addressed in earlier studies, the existing empirical evidence totally neglects an important dimension in Gulf Cooperation Council (GCC) markets: tribal culture. The authors fill this gap in the literature using Oman as the setting.Design/methodology/approachThe authors collect data for 583 company-year observations for companies listed on the Omani capital market, 2007–2014. The authors run a two-way fixed effects panel data regression to test their hypothesis.FindingsTribal culture has a negative effect on financial reporting quality (FRQ), measured by both accrual-based and real earnings management. The findings are robust under a variety of sensitivity analyses. In additional analysis, the findings confirm that tribal culture negatively moderates the effectiveness of internal monitoring mechanisms and is associated with low-quality auditing. Further, the authors find tribal culture associated with delayed financial information.Originality/valueTo the authors' knowledge, the study makes several contributions to the literature because it is the first archival evidence linking tribal culture with FRQ. It is the first to show that the effect of corporate governance mechanisms on FRQ is moderated by tribal culture. The study has valuable implications for policymakers, regulators, boards of directors and auditors in GCC countries as well as in countries with similar cultures.
Idiosyncratic volatility and interruption mechanisms in South Korean stock markets
Authors: Shin Seungho , Naka Atsuyuki , Alsunbul Saad 
Published: May 2021

PurposeThe purpose of this study is to examine how the volatility interruption (VI) mechanisms affect idiosyncratic volatilities in Korean stock markets.Design/methodology/approachCollecting the South Korea Stock Market (KOSPI) data from June 15, 2015 to March 31, 2019, we collect each residual, εi,t, from three different estimated models: capital asset pricing model (CAPM), FF3 and FF5. To estimate the conditional idiosyncratic volatility, the authors employ two conditional time-varying measurements: GARCH and TGARCH.FindingsThe results show that the conditional idiosyncratic volatility increases when stock prices reach the upper and lower static limits, indicating the implementation of adopting static VI mechanism neither stabilize market conditions nor reduce excess volatility along with the existence of price limits.Originality/valueAlthough market regulators and policymakers improve market conditions with the advanced VI mechanism, the empirical results show the adverse effect of the mechanism. Not allowing investors to earn above average returns without accepting above average risks makes Korean stock markets inefficient along with advanced VI mechanisms.
Beyond workaholism: differences between heavy work investment (HWI) subtypes in well-being and health-related outcomes
Authors: Snir Raphael , Harpaz Itzhak 
Published: May 2021

PurposeThe purpose of this paper is to explore well-being and health-related outcomes among all the four basic subtypes of heavy work investment (HWI), as well as a fifth distinct category of full-time workers (i.e. those who work from 35 to 43 weekly hours).Design/methodology/approachThe 510 respondents chosen to be included in the Internet survey were mostly heavy work investors. Based on two dimensions of causal attributions (causal locus and controllability), an elimination mode was used to classify heavy work investors into four main subtypes. Those who reported high financial needs were classified as needy. From the remaining heavy work investors, those who reported high organizational demands were classified as organization-directed. Afterward, those who reported high drive to work were classified as workaholics. Finally, those who reported high passion for work were classified as work-devoted.FindingsAmong the five categories of classified respondents, the work-devoted and the needy emerged as the most distinct categories. The work-devoted had the best outcomes (stronger positive feelings, better current health condition, better body mass index (BMI) and adequate hours of sleep a night), whereas the needy had the worst outcomes (a higher level of stress, bodily pain, aches that interfere with regular activities and weariness throughout the day).Originality/valueThis study addressed both long hours and high effort invested in work, and both dispositional and situational heavy work investors. A possible implication of this study is that when job applicants have similar human capital profiles, organizations should consider recruitment of work-devoted individuals for demanding jobs.
Immersive live streaming experience in satisfying the learners’ need for self-directed learning
Authors: Ho Ree Chan , Song Bee Lian 
Published: May 2021

PurposeThis study aims to examine live streaming experiences of business students’ at the tertiary education level, and how the use of this interactive platform satisfies their affective, cognitive, social and hedonic needs in learning. Likewise, it explored the influence of live streaming class on the learning outcome needed in achieving self-directed learning.Design/methodology/approachDrawing on the uses and gratifications theory, a conceptual framework was developed to discover the impact of interactive live streaming platform in meeting learners’ needs required for self-directed learning. A survey was conducted with a sample of 402 business undergraduate students from 5 universities. Data was analyzed with covariance-based structural equation modeling.FindingsThis study confirmed that learners’ gratifications gained from live streaming encouraged them to collaborate with the instructors in meeting the learning outcomes. The findings also supported that the interactive nature of live streaming offers the opportunity for students to learn independently. Thus, it sheds new light on how a live streaming learning environment can be further developed in promoting self-directed learning.Originality/valueThis study offers a novel understanding of live stream class adoption by examining learners’ needs from a uses and gratification perspective. It also contributed new insight to the existing literature on live streaming technology use in education to promote self-directed learning.
Inhabiting war craters examining geostatistical modeling within landscape heritage recovery in Aleppo
Authors: Elsayed Doaa Salaheldin Ismail 
Published: May 2021

PurposeAleppo city in Syria has witnessed severe bombardment since the 2011 war affecting its landscape heritage, causing explicit geomorphological changes with anthropogenic qualities. The research aims to log observations on the patterns of bombardment craters. It investigates their key role in guiding post-war recovery plans. Currently, the interpretation of war scars is not considered in the reconstruction plans proposed by local administrations and here lies the importance of the research.Design/methodology/approachThe study investigates the geomorphological transformations along the southern citadel perimeter in old Aleppo. Currently, digital tools facilitated data prediction in conflict areas. The research employs an empirical method for inhabiting war craters based on both qualitative and quantitative approaches. The former utilizes satellite images to define the geographical changes of landscape heritage. The latter applies geostatistical data analysis, validation, interpolation and simulation for multi-temporal Google Earth maps. The study exploits Surfer 13 software to localize and measure the preserved craters.FindingsThe research employs the generated models in a landscape design proposal examining the method's applicability. Finally, it offers a methodological toolkit guiding post-war landscape recovery toward the interpretation of conflict geography.Practical implicationsThe paper enables a practical understanding of the contemporaneity of landscape heritage recovery as an action between sustainable development and conservation.Social implicationsThe paper integrates the conflict geographies to the people's commemoration of places and events.Originality/valueThe article offers an insight into the rehabilitation of war landscapes focusing on land craters, exploiting geostatistical data prediction methods.