bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postpartum Depression: A Closer Look at Treatment with Zuranolone
Authors: Brudniak Katarzyna , Garbino Karolina , Czyczerska Magdalena , Szuścik Antoni , Gadżała Katarzyna , Przygodzka Sabina , Mach Maciej , Rutkiewicz Maciej 
Published: February 2025

Postpartum depression (PPD) is a severe mood disorder that affects approximately 1 in 7 women and 1 in 10 men, often occurring in the first year after childbirth. Its etiology is multifactorial, including hormonal changes, genetic predisposition, and environmental stressors, though its true prevalence is likely underestimated due to stigma and underreporting. Untreated PPD can have long-term consequences for maternal-child relationships, child development, and maternal health, including increased suicide risk. The condition remains underdiagnosed and undertreated due to stigma and systemic barriers to care. Zuranolone, an oral neuroactive steroid and positive allosteric modulator of GABA-A receptors, has recently garnered attention as a novel therapeutic option with the potential to target these underlying pathophysiological mechanisms.
Aim of the study: The aim of this study is to provide a comprehensive review of the therapeutic efficacy, safety, and pharmacological characteristics of Zuranolone in the treatment of postpartum depression (PPD), with focusing particularly on its mechanism of action, pharmacokinetics and clinical trial outcomes.
Materials and methods: A systematic literature review was conducted using PubMed and other medical databases. Keywords included "postpartum depression," "zuranolone," "GABA-A modulators,". Data from clinical trials, reviews, and pharmacological studies were analyzed.
Conclusions: Zuranolone has provided significant efficacy with a very rapid onset of action in the reduction of symptoms in postpartum depression and long-term improvements observed over several weeks. Its mechanism of action, targeting GABAergic dysregulation, offers a novel therapeutic pathway for addressing postpartum psychiatric disorders. Future longitudinal studies are required to explore its long-term impact on maternal mental health.
A LITERATURA INFANTIL COMO NORTEADORA DE PRÁTICAS PEDAGÓGICAS ANTIRRACISTAS NA EDUCAÇÃO INFANTIL
Authors: ALEXANDRE MOTA JULIA GABRIELLA , Reis Darianny Araújo dos 
Published: February 2025

O presente relato versa sobre uma prática pedagógica realizada em um Centro Municipal de Educação Infantil pertencente à rede pública municipal informação temporariamente suprimida para garantir o anonimato da autoria. Entrelaça os pressupostos da pedagogia antirracista com a literatura infantil no processo educativo desenvolvido com crianças pequenas, no contexto do Programa de Iniciação à Docência (PIBID), subprojeto Pedagogia, vinculado à Faculdade de Educação da informação temporariamente suprimida para garantir o anonimato da autoria. A partir desta experiência, buscamos discutir a necessidade de descolonizar as práticas educativas, ao tomarmos como base a implementação da Lei 10.639/2003, que tornou obrigatório o ensino da história e cultura afro-brasileira e africana em todas as escolas do país. A literatura infantil com protagonismo de personagens negros constituiu-se em principal material linguístico e simbólico de mediação para a conversa com crianças. A partir da obra “O pequeno príncipe preto”, de Rodrigo França (2020), problematizamos a questão da inferioridade racial ao colocarmos luz sobre o combate à ideologias racialistas e pseudocientíficas. Além disso, buscamos incentivar a formação do leitor literário numa perspectiva antirracista e descolonizadora, colaborando para a formação da identidade de crianças negras. Dos saberes construídos nesta experiência, pela qual permitiu-nos explicitar o papel da literatura infantil como aliada à luta antirracista, depreendemos a necessidade de ampliar as discussões sobre identidades, culturas e subjetividades nas práticas educativas, a partir de uma pedagogia crítica que possibilite experiências literárias antirracistas nas instituições de educação infantil.

Palavras-chave: Pedagogia antirracista; Literatura infantil; PIBID.
INIQUIDADES NO ACESSO ÀS CIRURGIAS CARDÍACAS NO BRASIL: UMA REVISÃO INTEGRATIVA
Authors: Lima Jaqueline Maria de Oliveira , Rosaneli Caroline Filla , Marcucci Fernando Cesar Iwamoto , Corradi-Perini Carla 
Published: February 2025

Essa pesquisa busca discutir as iniquidades no acesso às cirurgias cardíacas no Brasil e sua relação com os fatores sociodemográficos, econômicos e regionais. Trata-se de uma revisão integrativa da literatura que teve como pergunta norteadora “Quais os fatores relacionados às iniquidades no acesso à cirurgia cardíaca no Brasil?”. Para respondê-la, foi realizada em fevereiro de 2024, uma busca na base de dados da Biblioteca Virtual em Saúde (BVS), utilizando-se os descritores DeCS/MeSH combinados a partir do operador boleano “AND”: “cardiac surgery” and “inequality” and “Brazil” e “cardiac surgery” and “access” and “Brazil”. Dos 32 artigos encontrados, 13 foram selecionados após leitura dos resumos e textos completos. Diversas barreiras foram encontradas como questões relacionadas a desigualdades regionais e fatores sociais ao acesso às cirurgias cardiovasculares; desigualdades socioeconômicas; tempo de espera para cirurgias cardiovasculares; abordagens relacionadas a orientações pré e pós-cirurgias e recuperação hospitalar/domiciliar; problemas com acesso à cirurgia pediátrica; questões relacionadas ao acesso da informação pela classe médica; e fatores relacionados à formação de cirurgiões cardiovasculares. Diante dos desafios e das desigualdades como barreiras ao acesso às cirurgias cardíacas, faz-se necessário estruturar estratégias eficazes para garantir que todos os brasileiros tenham acesso igualitário e cuidados de saúde integral.
Differential diagnosis of non-traumatic knee hemarthrosis (case report)
Authors: Roskidaylo A. A. 
Published: February 2025

Hemarthrosis (HA) of the knee of non-traumatic origin is rarely encountered in the practice of a traumatologist-orthopedic surgeon. The differential diagnosis of this pathology requires a thorough medical history tacking and clinical examination of the patient, and a knee joint aspiration can only confirm the presence of blood in the joint. A diagnostic arthroscopy with a synovial biopsy helps to clarify the diagnosis. The most common causes of non-traumatic HA are tumors of vascular or synovial origin, tumor metastases and the use of high-dose anticoagulants in combination with a vascular malformation.A clinical observation of the development of symptoms of non-traumatic HA on the background of anticoagulant use is presented, where the task of the orthopedic surgeon was to identify the true cause of the disease.
F-stability, entropy and energy gap for supercritical Fujita equation
Authors: Wang Kelei , Wei Juncheng , Wu Ke 
Published: February 2025

Abstract
We study some problems on self-similar solutions to the Fujita equation when

p
>

(

n
+
2

)

/

(

n
−
2

)

p>(n+2)/(n-2)

, especially, the characterization of constant solutions by its energy.
Motivated by recent advances in mean curvature flows, we introduce the notion of 𝐹-functional, 𝐹-stability and entropy for solutions of supercritical Fujita equation.
Using these tools, we prove that, among bounded nonzero self-similar solutions, the constant solutions have the lowest entropy.
Furthermore, there is also a gap between the entropy of constant and non-constant solutions.
As an application of these results, we prove that if

p
>

(

n
+
2

)

/

(

n
−
2

)

p>(n+2)/(n-2)

, then the blow-up set of type I blow-up solutions is the union of an

(

n
−
1

)

(n-1)

-rectifiable set and a set of Hausdorff dimension at most

n
−
3

n-3

.
On the Laguerre polynomial approximation errors and lower type of entire functions of irregular growth
Authors: Kumar Devendra , Alghamdi Azza M. 
Published: February 2025

Abstract
It has been noted that lower type of an entire function completely ignores the value of lower order. The question arises for entire functions of irregular growth that what happens when we replace order by an arbitrary nonzero finite number. Here in this article our aim is to solve this problem by defining new lower

(

p
,
q

)

\left(p,q)

-type by using a

(

p
,
q

)

\left(p,q)

-scale,

(

p
≥
q
≥
1

)

\left(p\ge q\ge 1)

for an entire function. Moreover, a relationship has been established between lower

(

p
,
q

)

\left(p,q)

-type of entire function solutions of linear homogeneous partial differential equation of second order with coefficients occurring in series expansion and Laguerre polynomial approximation errors in sup norm.
An open-label, single dose, safety and pharmacokinetic study of Withania somnifera root extract in healthy volunteers
Authors: Sharma Eshita , Ganu Gayatri , Kshirsagar Ketan , Shah Ashwin , Mahale Umakant , Mehta Anirudh , Nair Sujit 
Published: February 2025

Abstract

Objectives

Withania somnifera (WS), also known as Ashwagandha, is a health-beneficial Ayurvedic medicinal plant with great potential as an adaptogen with rejuvenating and anti-aging effects. However, studies investigating pharmacokinetics (PK), safety, and tolerability of WS on humans are limited. The present study evaluated PK, safety, and tolerability of WS root extract (2.5 % total withanolides) capsules upon oral administration of two capsules of 200 mg each (total 400 mg) in healthy male and female volunteers.

Methods
An open label, single dose, clinical design comprising healthy volunteers was employed. The study evaluated PK parameters of the four bioactive constituents viz. withanoside IV, withaferin A, 12-deoxy-withastramonolide, and withanolide A in WS root extract after analysis of plasma using a validated UHPLC-MS/MS method. Further, safety and tolerability assessment for vital signs, testing for organ function, urine examination, X-ray, ECG, as well as adverse events profile were also investigated.

Results
After oral administration of 2 WS capsules (200 mg each), the participants reported normal physical, hematological, and biochemical parameters with no abnormalities in safety metrics. For the four bioactives, the exposure parameters range between 0.472 and 4.468 ng/mL (Cmax), 1.000–1.416 h (Tmax), and 2.051–13.319 ng/mL*h (AUC 0-t). Further, t1/2 (1.696–4.377 h), lambda_z (0.141–0.282 L/h), Cl/F (0.065–0.954 mg/(ng/ml)/h), AUMC 0-inf_obs (21.720–80.485 ng/mL*hˆ2) and MRT 0-inf_obs (3.680–7.516 h) also differed for each bioactive.

Conclusions
The present study elucidated the PK of WS and showed that healthy male and female volunteers may safely consume WS capsules at a dose of 400 mg (2 capsules of 200 mg) without any harmful effects.
Use of modeling, BIM technology, and virtual reality in nondestructive testing and inventory, using the example of the Trzonolinowiec
Authors: Napiórkowski Mateusz , Szóstak Mariusz , Schabowicz Krzysztof , Klimek Adam 
Published: February 2025

Abstract
This article presents the use of the building information modeling (BIM) methodology during the inventory of a residential building called “Trzonolinowiec” located in Wroclaw, Poland. The use of BIM methodology makes it possible to obtain more accurate two-dimensional (2D) documentation based on the three-dimensional (3D) model of the surveyed object. The article additionally discusses the possibility of extending the conducted inventory with new technologies (including laser scanners, unmanned aerial vehicles, and virtual reality [VR]). Laser scanners make it possible to take fast and accurate measurements in the form of point clouds, based on which it is possible to make accurate 3D models and then 2D projections. Unmanned aerial vehicles make it possible to inspect in hard-to-reach places and to make a point cloud (once the scanner is connected) of the facade and roof. VR was presented as a technology that allows immersive viewing of a virtual environment – a 3D model. The article discusses the scope prepared for the expertise and possible future directions during subsequent inventories. A 3D model of the inventoried building was prepared, mapping the building’s geometry and its location in the local geodetic system as an example of the capabilities of the proposed technologies. The paper discusses the scope prepared for the expertise, possible future directions during subsequent inventories, and the current limitations of the proposed solutions.
Financial Stability and Monetary Policy Autonomy in Japan. Should Japan Peg the Yen to the Dollar?
Authors: Schnabl Gunther , Schürmann Christof 
Published: February 2025

Abstract
Given rising inflation the Bank of Japan has come under pressure to tighten monetary policy. The paper examines the risks of an interest rate hike for the sustainability of Japanese government debt, the Bank of Japan and the Japanese financial sector and derives possible repercussions for national and international financial stability. It finds significant valuation and currency risks in the private financial sector that limit the Bank of Japan’s room for manoeuvre. Pegging the yen to the dollar would eliminate appreciation expectations and reduce inflation risk. The loss of freedom in monetary policy making would be small.
Numerical study of catalytic converter geometries and their impact on exhaust back pressure and energy conversion in engine exhaust systems using parametric simulation: insights into non-equilibrium thermodynamics
Authors: Thakur Arpit , Sharma Ashish , Kumar Rajeev , Sharma Shubham , Patil Nagaraj , Kanchan Sumit , Raja V.K. Bupesh , Mahapatro Abinash , Gupta Deepak , El Sayed Massoud Ehab 
Published: February 2025

Abstract
In this investigation, the principles of non-equilibrium thermodynamics are employed to investigate the implications of geometric parameters on engine performance and exhaust back pressure in catalytic converters. The effects of components utilized for engine exhaust management on exhaust back pressure and anomalous engine operation have been extensively studied. This study explores how the geometric parameters of catalytic converters influence back pressure in the exhaust manifold through a detailed numerical analysis. Five models of catalytic converter with different geometric parameters at the inlet section, outlet section, inlet cone angle, outlet cone angle, and porous zone were tested to determine the variations in back pressure. For the monolith, a porous region is used where inertia and viscosity are defined by Darcy’s law, and discrete channel simulation is performed using the “Reynolds-average Naiver-Stokes (RANS) equations”, k-ω turbulence model, and a pressure-based solver. The numerical findings revealed that back pressure increased by up to 15 % with the rise in exhaust gas velocity from 0 to 25 m/s. Among the five models, the optimal configuration reduced back pressure by approximately 20 % compared to the baseline model, primarily due to adjustments in the length of the porous zone and conical sections. The outcomes demonstrate that the back pressure rises as the velocity of exhaust gas rises, and the optimization of configurations is determined by the design of the porous zone and conical sections. The findings prove that the efficiency of catalytic converters is considerably enhanced through the role of transport processes of mass, momentum, and energy, as variations in geometric configurations have a substantial effect on back pressure. Ultimately, this research offers valuable insights that could lead to the development of more efficient catalytic converters, thereby enhancing the control of automotive emissions and sustainable environmental practices. Key contributions of this study include a systematic evaluation of back pressure variations across multiple geometries, offering a pathway for enhanced engine performance and reduced environmental impact. The results have practical implications in improving design methodologies for catalytic converters, with potential applications in real-world automotive manufacturing.
Numerical investigation on fluid-thermal-electric performance of a thermoelectric-integrated helically coiled tube heat exchanger for coal mine air cooling
Authors: Lu Xing , Dai Renkun , Deng Jun , Ma Ting 
Published: February 2025

Abstract
Mine cooling and refrigeration system to deal with the heat hazard is well developed, but the mine air cooler which serves as the most important terminal equipment is relatively backward. The severe heat hazard and urgent cooling demand in deep underground mines necessitate further improvement of cooling capacity and effectiveness under strict requirements such as being compact, portable, nontoxic, and no-pollution. The thermoelectric (TE) energy conversion technology has great potential in cooling and miniaturization applications, which can meet the strict requirements of the underground mine cooling devices. Yet, a research gap exists in integrating TE energy conversion technology with the traditional air-cooling heat exchanger to the best of our knowledge. In this work, a hybrid utilization of TE and the helically coiled tube heat exchanger (HCEX) is proposed for air cooling at the working face of underground mine. The advantage of the TE-integrated HCEX lies in the combination of the heat transfer enhancement effect by secondary flow induced inside the helically coiled tube and the solid-state Peltier cooling effect by the TE module positioned on the external shell wall of the heat exchanger, which can potentially improve the air-cooling capacity without occupying large space. A numerical simulation of the fluid-thermal-electric multiphysics field is performed to investigate the cooling rate and the effectiveness of the TE-integrated HCEX. Results show that additional cooling power can be effectively provided by TE. As the filling ratio (FR) of TE module on the external shell wall increases from 50 to 100%, the air-cooling capacity continuously increases, performing better than that of the conventional HCEX. The effect of air inlet temperature and inlet velocity on the cooling performance is investigated for the best design of the TE-integrated HCEX with FR of 100%. When the inlet temperature of air increases from 303.15 to 313.15 K under constant inlet velocity, the cooling rate increases and cooling effectiveness decreases. Also, the cooling rate increases and the cooling effectiveness decreases when the inlet velocity of air increases from 10 to 25 m s−1 under constant inlet temperature. Within the simulated range of air inlet conditions in this work, the maximum total cooling rate Q
c,total at optimal current of 6 A for the TE-integrated HCEX results in an enhancement of 49.8 to 35.0% compared to the conventional HCEX. The maximum cooling effectiveness at optimal current of 6 A is 21.73–26.49% for the TE-integrated HCEX, which is higher than the effectiveness of the conventional HCEX of 15.74–18.24%.
Zu ausgewählten Amuletten der Römischen Kaiserzeit und Völkerwanderungszeit in der westlichen
Germania magna
Authors: Schulte Lothar 
Published: February 2025

Zusammenfassung
Kaum Beachtung fanden bisher zahlreiche Objekte der Römische Kaiserzeit und Völkerwanderungszeit in der westlichen Germania magna, die als Amulette gedeutet werden können und denen eine Bedeutung im Volksglauben oder der Volksmedizin zukam. Aus einer Vielzahl an infrage kommenden Exemplaren werden Fossilien (Echiniten, Belemniten und weitere), prismatische Knochenanhänger („Donaramulette“), durchbohrte Hartteile von Tieren (Zähne, Krallen und Knochen), Geweihrosenringe, verzierte Ringe und Scheiben aus Bein, Ringbrünnen (Kettengeflechte) sowie gebundene Anhänger untersucht. Im Vordergrund stehen die Fragen nach Gruppenzuordnungen, räumlichen und zeitlichem Vorkommen. Dabei stellt sich heraus, dass all diese Objekte überwiegend in Gräbern von Frauen und subadulten Individuen vorkommen, einzelne Objekttypen bedeutend seltener, aber gesichert auch in Männergräbern. Während eine Reihe von Amuletten, wie Fossilien, durchbohrte Hartteile von Tieren und wohl auch Geweihrosenringe, bereits zu Beginn der älteren Römischen Kaiserzeit vorkommen und in einer längeren Tradition stehen, erscheinen gebundene Anhänger, Cypraea-Schnecken, Kettengeflechte und prismatische Knochenanhänger sukzessive als neue Amulette im Untersuchungszeitraum. Sie alle fanden wenigstens bis ins frühe Mittelalter weiter Verwendung.
Für eine Reihe von Objekten ist anzunehmen, dass ihnen einen Amulettcharakter zugesprochen wurden. Die bislang geringe Fundanzahl von Geweihstangen, Quarzobjekten, durchbohrten Terra sigillata-Scherben, Glas- und Bernsteinanhänger, Archaika sowie unterschiedlichen, als besonders anzusehenden Steinen, wie „Krähensteine“, „Adlersteine“ oder „Hühnergötter“, lässt es allerdings fraglich erscheinen, ob sie regelhaft Verwendung fanden, sie nur lokal oder individuell genutzt wurden oder es sich bei ihnen lediglich um Schmuckstücke handelte.
ТЕРРИТОРИАЛЬНЫЕ СТРУКТУРЫ ХОЗЯЙСТВА В РАЙОНАХ НОВОГО ОСВОЕНИЯ
Authors: БАКЛАНОВ П.Я. , МОШКОВ А.В. 
Published: February 2025

В регионах Тихоокеанской России выделены две меридиональные зоны, состоящие из территорий субъектов РФ: приморская (Чукотский автономный округ, Магаданская область, Камчатский, Хабаровский и Приморский края, Сахалинская область) и континентальная (республики Якутия и Бурятия, Забайкальский край, Амурская область и Еврейская автономная область). Сочетания видов деятельности по субъектам и меридиональным зонам рассматриваются как элементы их территориально-хозяйственных структур. Показаны различия меридиональных зон по их территориальным структурам хозяйства, социально-экономическому потенциалу и уровню освоенности. Отмечено, что наибольший уровень развития характерен для территориально-хозяйственных структур приморской зоны. Для меридиональных зон выделяются благоприятные и неблагоприятные факторы долгосрочного развития. Рациональное использование этих факторов может обеспечить формирование структуры хозяйства регионов в виде взаимосвязанных цепочек добавленной стоимости, представляющих собой эффективные формы территориальной организации производства.
In the regions of Pacific Russia, two meridional zones have been identified, consisting of the following territories (federal subjects of the Far Eastern Federal District): 1) the seaside zone including Chukotka Autonomous Okrug, Magadan Oblast, Kamchatka, Khabarovsk and Primorsky Krais, and Sakhalin Oblast; and 2) the continental zone including the Republics of Yakutia and Buryatia, Zabaikalsky Krai, Amur Oblast and Jewish Autonomous Oblast. Combinations of industries by federal subjects and by meridional zones are considered as elements of their territorial and economic structures. The differences between the meridional zones according to their territorial structures of economy, socio-economic potential and the level of development are shown. It is noted that the highest level of development is typical for the territorial and economic structures of the seaside zone. Favorable and unfavorable factors of the long-term development in the meridional zones are distinguished. Rational use of these factors can ensure the formation of the structure of the regional economy in the form of interconnected chains of added value, which represent effective forms of territorial organization of production.