bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning: An Advanced Platform for Materials Development and State Prediction in Lithium‐Ion Batteries
Authors: Lv Chade , Zhou Xin , Zhong Lixiang , Yan Chunshuang , Srinivasan Madhavi , Seh Zhi Wei , Liu Chuntai , Pan Hongge , Li Shuzhou , Wen Yonggang , Yan Qingyu 
Published: September 2021

AbstractLithium‐ion batteries (LIBs) are vital energy‐storage devices in modern society. However, the performance and cost are still not satisfactory in terms of energy density, power density, cycle life, safety, etc. To further improve the performance of batteries, traditional “trial‐and‐error” processes require a vast number of tedious experiments. Computational chemistry and artificial intelligence (AI) can significantly accelerate the research and development of novel battery systems. Herein, a heterogeneous category of AI technology for predicting and discovering battery materials and estimating the state of the battery system is reviewed. Successful examples, the challenges of deploying AI in real‐world scenarios, and an integrated framework are analyzed and outlined. The state‐of‐the‐art research about the applications of ML in the property prediction and battery discovery, including electrolyte and electrode materials, are further summarized. Meanwhile, the prediction of battery states is also provided. Finally, various existing challenges and the framework to tackle the challenges on the further development of machine learning for rechargeable LIBs are proposed.
Metal‐Free, PhI(OAc)2‐Promoted Oxidative C(sp2)−H Difunctionalization: Synthesis of Thioaminated Naphthoquinones
Authors: Pal Satyajit , Chatterjee Rana , Santra Sougata , Zyryanov Grigory V. , Majee Adinath 
Published: September 2021

AbstractA three‐component thioamination reaction has been developed in the presence of phenyliodonium(III) diacetate (PIDA) leading to the formation of a thioaminated products. This catalytic approach represents a method for the metal‐free thioamination of 1,4‐naphthoquinone. It was observed that maleimides also work smoothly under this metal‐free reaction condition. This present method implies the oxidative coupling reaction through a one‐step process with the generation of C−N and C−S bonds. Various aromatic and aliphatic thiols and amines provided the corresponding thioaminated compounds in 62–88% yields. A plausible reaction pathway has been predicted according to few control experiments.magnified image
Excess Serum Interleukin‐18 Distinguishes Patients With Pathogenic Mutations in PSTPIP1
Authors: Stone Deborah L. , Ombrello Amanda , Arostegui Juan I. , Schneider Corinne , Dang Vinh , de Jesus Adriana , Girard‐Guyonvarc'h Charlotte , Gabay Cem , Lee Wonyong , Chae Jae Jin , Aksentijevich Ivona , Goldbach‐Mansky Raphaela T. , Kastner Daniel L. , Canna Scott W. 
Published: September 2021

ObjectiveDominantly inherited PSTPIP1 mutations cause a spectrum of autoinflammatory manifestations epitomized by PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome.). The connections between PSTPIP1 and PAPA syndrome are poorly understood, although evidence suggests involvement of pyrin inflammasome activation. Interleukin‐18 (IL‐18) is an inflammasome‐activated cytokine associated with susceptibility to macrophage activation syndrome (MAS). This study was undertaken to investigate an association of IL‐18 with PAPA syndrome.MethodsClinical and genetic data and serum samples were obtained from patients referred to institutions due to symptoms indicative of PAPA syndrome. Serum IL‐18, IL‐18 binding protein (IL‐18BP), and CXCL9 levels were assessed by bead‐based assay, and free IL‐18 levels were assessed by enzyme‐linked immunosorbent assay.ResultsThe symptoms of PSTPIP1‐positive patients with PAPA syndrome overlapped with those of mutation‐negative patients with PAPA‐like conditions, but mutation‐positive patients had earlier onset and a greater proportion had a history of arthritis. We found uniform elevation of total serum IL‐18 in treated PAPA syndrome patients at levels nearly as high as those seen in NLRC4‐associated autoinflammation with infantile enterocolitis patients, and well above levels found in most familial Mediterranean fever patients. Serum IL‐18 elevation in PAPA syndrome patients persisted despite fluctuations in disease activity. Levels of the soluble IL‐18 antagonist IL‐18BP were modestly elevated, and PAPA syndrome patients had detectable free IL‐18. PAPA syndrome was rarely associated with elevation of CXCL9, an indicator of interferon‐γ activity, but no PAPA syndrome patients had a history of MAS.ConclusionPAPA syndrome is a refractory and often disabling monogenic autoinflammatory disease associated with chronic and unopposed elevation of serum IL‐18 levels but not with risk of MAS. These findings affect our understanding of the diseases in which IL‐18 is overproduced and suggest a link between pyrin inflammasome activation, IL‐18, and autoinflammation, without susceptibility to MAS.
Tracking Progress: Reprising the Texas Water Conservation Scorecard
Authors: Kramer Ken , Bock Meghan , Johnston Ian , McClendon Cate , Walker Jennifer 
Published: September 2021

Key TakeawaysIn 2020, the Texas Living Waters Project reprised its innovative 2016 Texas Water Conservation Scorecard.The revised scores indicated no significant improvement overall in municipal water conservation efforts, but there were some positive trends.The updated scorecard found that water loss control remains a major challenge for Texas water utilities, including those in large cities.The potential for further advancing water conservation in Texas remains strong, and several utilities provide models for success.
Techno‐economics of one‐stage and two‐stage furfural production integrated with ethanol co‐production from sugarcane lignocelluloses
Authors: Ntimbani Rhulani N. , Farzad Somayeh , Görgens Johann F. 
Published: September 2021

AbstractLignocellulosic biomass processing to produce platform chemicals and biofuels is a promising alternative utilization of non‐renewable resources. This study investigated the techno‐economics of two‐stage and one‐stage furfural production integrated with ethanol co‐production from sugarcane bagasse and harvest residues. The effect of process conditions on profitability was reflected by the minimum ethanol selling price (MESP) at a fixed furfural‐selling price. Aspen Plus V8.8 was used to simulate the integrated two‐stage furfural and ethanol co‐production biorefineries using low (scenario 1), medium (scenario 2) and high (scenario 3) severity steam‐explosion pretreatment. The two‐stage furfural biorefineries integrated with ethanol co‐production were compared with the most profitable one‐stage furfural biorefinery integrated with ethanol co‐production. The required MESP in scenario 2 (0.73 US$ L–1) was decreased by 36% compared with the one‐stage furfural‐ethanol biorefinery (1.14 US$ L–1). Scenarios 1 and 3 were disadvantaged by lower ethanol yields (150 versus 214 kg t–1 of feed) and higher capital investments (322–340) compared with scenario 2 (310 million US$). The one‐stage furfural production had higher heating demands (2034 versus 741–1124 kW t–1 feed) and reduced ethanol yields (90 versus 150–214 kg t–1 of feed) compared with integrated two‐stage furfural and ethanol coproduction biorefineries. Optimization of process conditions, improving energy efficiency, and maximizing productivity within these energy self‐sufficient facilities were critical to minimizing the MESPs, regardless of associated increases in capital and operational costs. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
A bibliometric analysis on potential uses of brewer's spent grains in a biorefinery for the circular economy transition of the beer industry
Authors: Sganzerla William G. , Ampese Larissa C. , Mussatto Solange I. , Forster‐Carneiro Tânia 
Published: September 2021

AbstractThis comprehensive review aims to elucidate the state of the art related to research trends regarding the use of brewer's spent grains (BSG), the main solid by‐product generated in breweries. Its status, future opportunities, and emerging trends were evaluated by bibliometric analysis, which contributed to clarifying the knowledge and perspectives in the field. In total, 510 documents were obtained from the Web of Science© database in a timespan from 1900 to 2020. VosViewer software and R‐bibliometrix package were used to investigate and map the most frequently cited papers, international collaborative networks, keywords, and the main countries and journals associated with this research. The results showed that, globally, 65 countries have been engaged in research related to BSG, and Brazil has been the most productive country, with up to 70 publications. Keyword analysis revealed that the studies on BSG are divided into four main knowledge areas: (i) pretreatment; (ii) nutritional quality; (iii) bioactive compounds, and (iv) pyrolysis. It was also found that a biorefinery can be designed for the complete utilization of BSG to obtain several valuable compounds. In this sense, different technological routes can be applied to produce arabinoxylans, proteins, ferulic acid, xylitol, xylose, lactic acid, butanol, biogas, fertilizer, and ethanol. In conclusion, BSG is a cost‐effective and feasible raw material for the sustainable production of bio‐based products and bioenergy and its valorization in a biorefinery is a powerful strategy to promote the circular economy transition of the beer industry. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Clinical and neurodevelopmental outcomes based on brain imaging studies in a Colombian cohort of children with probable antenatal Zika virus exposure
Authors: Daza Marcela , Mercado Marcela , Moore Cynthia A. , Valencia Diana , Lengua Maria Fernanda , Newton Suzanne , Rodríguez Blanca , Tong Van T. , Acevedo Pedro , Gilboa Suzanne M. , Ospina Martha L. , Mulkey Sarah B. 
Published: September 2021

AbstractBackgroundOur aim was to describe the neuroimaging and clinical evaluations of children with antenatal Zika‐virus (ZIKV) exposure.MethodsThe Colombian National Institute of Health performed serial clinical evaluations of children with probable antenatal ZIKV exposure (i.e., born to ZIKV symptomatic mothers or born with birth defects compatible with ZIKV infection, regardless of laboratory results) over 2 years that included head circumference (HC), eye examination, and neurodevelopmental assessments. Clinical neuroimaging studies (head computed tomography and/or brain magnetic resonance imaging) were analyzed for abnormalities, two‐dimensional measurements were made of the right and left frontal and occipital cortical thickness. Two abnormal patterns were defined: Pattern 1 (sum of four areas of cortex <6 cm) and Pattern 2 (sum of four areas of cortex ≥6 cm and < 10 cm).ResultsThirty‐one children had a neuroimaging study; in 24, cortical thickness was measured. The median age at the first visit was 8 (range: 6–9) months and 22 (range: 19–42) months at the last evaluation. In the 24 cases with cortical measurements, three were normal, 12 were in Pattern 1, and nine were in Pattern 2. Children within Pattern 1 had lower mean HC at birth and in follow‐up (both p < .05) and a higher frequency of structural eye abnormalities (p < .01). A trend towards poorer neuromotor development was seen in Pattern 1, although not statistically significant (p = .06).ConclusionBrain imaging classification based on cortical measurements correlate with ophthalmologic abnormalities and HC. Cortical thickness may be a marker for clinical outcomes in children with congenital ZIKV infection.
Prenatal‐onset of congenital neuronal ceroid lipofuscinosis with a novel CTSD mutation
Authors: Chartier Suzanne , Boutaud Lucile , Le Guillou Edouard , Alby Caroline , Billon Clarisse , Millischer Anne‐Elodie , Caillaud Catherine , Galmiche Louise , Mechler Charlotte , Sonigo Pascale , Boddaert Nathalie , Lyonnet Stanislas , Rondeau Sophie , Bole‐Feysot Christine , Masson Cécile , Ville Yves , Roth Philippe , Desguerre Isabelle , Encha‐Razavi Férechté , Attie‐Bitach Tania 
Published: September 2021

AbstractBackgroundNeuronal ceroid lipofuscinoses (NCLs) form a clinically and genetically heterogeneous group of inherited neurodegenerative disorders that share common neuropathological features. Although they are the first cause of neurodegenerative disorders in children, their congenital forms are rarely documented. They are classically due to mutations in the CTSD gene (the CLN10 disease). Affected newborns usually present severe microcephaly, seizures and respiratory failure leading to death within the first postnatal days or weeks.CasesWe report on two siblings, in which exome sequencing identified a novel homozygous CTSD variant. The first sib presented at birth with seizures, rapidly progressive postnatal microcephaly and visual deficiency related to retinal dysfunction. Progressive neurological deterioration leads to death at the age of 24 months. Cathepsin D activity was reduced in the cultured fibroblasts of this patient. The second sib, a fetus of 36 weeks of gestation, was delivered after pregnancy termination for brain abnormalities (in accordance with French Legislation) suggesting a recurrence of the disease. Fetal postmortem examination disclosed neuropathological features consistent with NCL.ConclusionsCongenital NCL related to CTSD mutations is a neuronal storage disorder that produces in the developing brain diffuse neurodegeneration and white matter atrophy resulting in a progressive and rapidly lethal microcephaly.
Impending rupture of a chronic contained abdominal aortic aneurysm with a 14‐day history
Authors: Yamada Takayuki , Ohwada Susumu , Okauchi Kenzo , Hasegawa Yutaka 
Published: September 2021

AbstractThis case of an impending abdominal aortic aneurysm rupture emphasizes impaired consciousness with low back pain. Family doctors must be attentive to a patient's physical findings and medical history, even if vital signs are normal at the initial visit.
Resolving severe oligohydramnios as an early prenatal presentation of renal coloboma syndrome—A report of two generations
Authors: Nguyen Andrew , Campagnolo Carla , Hardy Ghislain , Saleh Maha 
Published: September 2021

AbstractThis report suggests that self‐resolving oligohydramnios is an early sign of malfunctioning kidney in individuals with renal coloboma syndrome (RCS) and demonstrates how a genetic diagnosis can impact patient and fetal management as it outlines two generations of RCS.
Hepatocellular carcinoma in a non‐cirrhotic liver with a tumor thrombus
Authors: Sadiq Abid M. , Mashonganyika Tendai J. , Mmbaga Lilian G. , Sadiq Adnan M. , Nkya Gilbert Z. 
Published: September 2021

AbstractYoung adults with HCC tend to have a poor prognosis because of advanced disease despite preserved liver function. Screening and early diagnosis for HCC are needed for young adults to demonstrate an improved prognosis, especially in HBsAg positive patients.
Seed‐Mediated Synthesis of Colloidal 2D Halide Perovskite Nanoplatelets
Authors: Guvenc Cetin Meric , Balci Sinan 
Published: September 2021

AbstractColloidal synthesis of two‐dimensional lead halide perovskite nanoplatelets (2D LHP NPLs) with a general formula of L2[APbX3]n−1PbX4 has been widely performed by using hot‐injection or ligand assisted reprecipitation methods. Herein, for the first time, we report on seed‐mediated synthesis of two and three monolayers (n=2, 3) lead halide perovskite nanoplatelets without using A‐site cation halide salt (AX; A=Cesium, methylammonium, formamidinium and, X=Cl, Br, I) and long chain alkylammonium halide salts (LX; L=oleylammonium, octylammonium, butylammonium and, X=Cl, Br, I). The nanocrystal seeds have been prepared by reacting lead (II) halide salt and coordinating ligands in a nonpolar solvent and then they have been reacted with cesium oleate, formamidinium oleate or methylamine. Our facile synthesis route enabling further understanding of the growth dynamics of LHP NPLs provides highly stable, monodisperse NPLs with very narrow absorption and emission linewidths (min. 68 meV), and high PLQY (max. 37.6%).
A novel mathematical modeling in shift in emotion for gauging the social influential in big data streams with hybrid sarcasm detection
Authors: P. Kumaran , S. Chitrakala 
Published: September 2021

SummaryOnline social network is a platform that plays an essential role in identifying the emotional values of user‐generated content such as blogs, posts, and comments along with their influential factors. Especially on Twitter, network users are growing worldwide day by day and creating a massive amount of data that is not analyzed effectively in a quick way. Identifying the most influential persons on the social network is also a challenging task over the wide range of real‐time applications like recommendation systems. Now, to handle these situations, this article proposes a novel approach for prediction of information diffusion that includes emotion recognition with sarcasm detection based influence spreader identification (PID‐ERSDISI). The proposed method uses the user‐generated posts for emotion recognition in tandem with sarcasm detection both implicitly and explicitly. This approach helps to gauge the leverage that influences spreaders and also enhances the prediction accuracy of information diffusion in a better way. The implementation of the proposed work executed their task one after another in the following way, namely, sarcasm detection, emotional‐level computation, breakpoint computation, breakpoint validation, influential user generation, and information diffusion. After the successful implementation of this proposed PID‐ERSDIS, it produced prominent results against other state‐of‐art methods.
Systematic Evaluation of the Effects of Toxicant Exposure on Survival in Zebrafish Embryos and Larvae
Authors: Ramdas Nair Anjana , Delaney Patrice , Koomson Abigail Ama , Ranjan Shashi , Sadler Kirsten C. 
Published: September 2021

AbstractThe use of whole animal models in toxicological studies is essential for understanding the physiological responses caused by chemical exposures. However, such studies can face reproducibility challenges due to unaccounted experimental parameters that can have a marked influence on toxicological outcomes. Zebrafish embryos and larvae are a popular vertebrate animal model for studying cellular, tissue, and organ responses to toxicant exposures. Despite the popularity of this system, standardized protocols that control for the influence of various experimental parameters and culture conditions on the toxicological response in these animals have not been widely adopted, making it difficult to compare findings from different laboratories. Here, we describe a detailed approach for designing and optimizing protocols to assess the impact of chemical exposures on the development and survival of zebrafish embryos and larvae. We first describe our standard procedure to determine two key toxicological thresholds, the maximum tolerable concentration (MTC) and the lethal concentration (LC50, defined as that in which 50% of larvae die), in response to an exposure that persists from early development through larval maturation. We then describe two protocols to systematically test how key experimental parameters, including genetic background, culture media, animal density, volume, plate material, and developmental stage in which the embryos are exposed, alter the MTC and LC50. Finally, we provide a step‐by‐step guide to assess the interaction between two chemicals using this model. These protocols will guide the standardization of toxicological studies using zebrafish and maximize reproducibility. © 2021 Wiley Periodicals LLC.Basic Protocol 1: Zebrafish embryo collection and culture, and establishment of the MTC and LC50Basic Protocol 2: Evaluation of the impact of culture conditions on toxicant responses of zebrafish embryo and larvaeBasic Protocol 3: Identification of the developmental window of sensitivity to toxicant exposureBasic Protocol 4: Testing interaction between multiple toxicants
Whose voice is it anyway? Narrative perspectives within the Scottish and Swedish Science curricula
Authors: Billmayer Jakob , Day Stephen P. 
Published: September 2021

AbstractThis study explores the form of curriculum documents and its implications for the enacted curriculum. In this study, the narrative voices that appear in the Scottish Broad General Education phase and the Swedish Compulsory phase of the curriculum are scrutinized in relation to the most likely reader of these documents—the teacher. The study adopts a critical hermeneutic approach to documents relating to the Swedish and Scottish Science curricula, focusing on the primary and lower secondary school phase of education. In addition, the analysis utilised the concepts and categories from narratology as an analytical framework that illuminates the emerging narrative voices in the curriculum documents. Both countries are similar in terms of “the teacher” not appearing in a prominent role but differ in terms of how teachers are framed from a narratological perspective. While the Swedish science curriculum appears to be a very rudimentary narrative, resembling “stage directions” for teachers' activity, the Scottish science curriculum contains a variety of different narrative voices, although none of these puts the teacher in an active, autonomous or decision‐making position.
“We must assess all, even a student farting [is also assessed] for the behavioural aspect of learning”: Teachers' conceptions of assessment in the context of assessment reform in Indonesia
Authors: Arrafii Mohammad Arsyad 
Published: September 2021

AbstractThis paper explores Indonesian secondary school teachers' conceptions of assessment in the context of assessment reform. Teachers working at different school level were interviewed both individually and in groups and their responses were analysed using the content analysis approach. Detailed examination of teachers' assessment propositions revealed that their perspectives about assessment embrace values, purposes, and understanding, and are marked by conceptions about the learner agency, accountability and improvement orientations. However, despite being considered important, the learner agency and accountability conceptions were often considered irrelevant. In addition, teachers reported tension with regard to their perceptions towards the reform and demonstrated a varied level of conceptual and practical understanding of the reform. The paper ends with a discussion of the complex nature of and tensions in the teachers' conceptions of assessment. Principal implications are discussed.
Metastatic olfactory neuroblastoma: A small round blue cell puzzle on fine‐needle aspiration cytology
Authors: Penzhorn Ingrid H. , Schubert Pawel T. 
Published: September 2021

AbstractSmall round blue cell tumors (SRBCTs) are a heterogeneous group of malignant neoplasms that can be challenging to distinguish on fine‐needle aspiration (FNA) cytology. Ancillary tests as well as clinico‐radiological correlation are often required to make an accurate diagnosis. FNA is a low‐cost, low‐infrastructure test, making it a coveted diagnostic tool, especially in low‐resource settings. Olfactory neuroblastoma (ONB) is a rare SRBCT encountered in both pediatric and adult patients. Awareness of the cytomorphologic and immunocytochemical features of ONB is important in the workup of a SRBCT. This case report describes the primary diagnosis of metastatic ONB on FNA cytology.