bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jeszcze raz w sprawie działalności Piotra i Mikołaja Komorowskich na Górnych Węgrzech w XV wieku
Authors: Krajewski Karol 
Published: December 2021

Autor artykułu podejmuje temat aktywności Piotra i Mikołaja Komorowskich herbu Korczak na obszarze północnej części Królestwa Węgierskiego w XV wieku. Działalność ta jest ściśle związana z tematem Górnych Węgier w tym okresie, tematem, który był już od początku nowoczesnej historiografii wielokrotnie opracowywany, szczególnie w historiografii słowackiej i polskiej. W artykule podjęto próbę weryfikacji tego dorobku. Autor skupia się na działalności Piotra i Mikołaja Komorowskich na terenach węgierskich w latach od około 1440 do około 1480 roku. Opisując aktywności Mikołaja Komorowskiego, wskazuje między innymi na jego czynny udział jako dowódcy wojskowego w wojnie domowej na Węgrzech po stronie Władysława III Jagiellończyka czy też konflikt tego możnego z biskupem krakowskim Zbigniewem Oleśnickim o starostwo spiskie. Wśród działań Piotra Komorowskiego opisane zostały: stopniowe budowanie pozycji na obszarze Górnych Węgier za życia Władysława III Jagiellończyka i w okresie po jego śmierci, rywalizacji i współpraca z innymi możnymi działającymi w tym regionie, włączenie się przez Komorowskiego w wydarzenia związane z aktywnością tzw. bratrzyków oraz udział w konfliktach między Kazimierzem Jagiellończykiem a Maciejem Korwinem.
Andrzej Radzimiński: Kontakty duchowieństwa ze Stolicą Apostolską. Obraz życia średniowiecznego kleru w dokumentach Penitencjarii Apostolskiej. Toruń, Wydawnictwo Naukowe Uniwersytetu Toruńskiego, 2020, ss. 244
Authors: Saczyńska-Vercamer Monika 
Published: December 2021

Andrzej Radzimiński: Kontakty duchowieństwa ze Stolicą Apostolską. Obraz życia średniowiecznego kleru w dokumentach Penitencjarii Apostolskiej. Toruń, Wydawnictwo Naukowe Uniwersytetu Toruńskiego, 2020, ss. 244
David Radek: Bolek V. Opolský (okolo 1400—1460). Život a legenda. Opava, Slezská univerzita v Opavě, 2018, ss. 310
Authors: Zawadzki Tomasz 
Published: December 2021

David Radek: Bolek V. Opolský (okolo 1400—1460). Život a legenda. Opava, Slezská univerzita v Opavě, 2018, ss. 310
PEMANFAATAN INTERNET SEHAT MENUJU GENERASI UNGGUL DI ERA MILENIAL
Authors: Adji Suradji Muhammad  , Imam Yudhi Prastya  
Published: December 2021

Perkembangan informasi dan komunikasi melalui teknologi saat ini begitu cepat, sehingga tidak mengenal batas wilayah dan batas privasi. Perkembangan teknologi tersebut juga memicu hadirnya media baru yang dikenal dengan Media Sosial. Media sosial pada umumnya adalah media yang digunakan untuk bersosialisasi atau berhubungan, baik secara personal maupun impersonal antar penggunanya. Beberapa aplikasi media sosial yang ada saat ini antara lain adalah WhatsApp, Facebook, Twiter, Blackberry Massager, Path, Skype, Instagram SNS dan Communication Network. Secara garis besar media sosial dan jaringan sosial menggunakan sistem yang sama yaitu media daring yang terhubung dengan internet. Pada media sosial dan jaringan sosial, ada banyak orang yang saling terhubung satu sama lain tanpa dibatasi dengan batas fisik seperti geografis, ruang, bahkan waktu dengan tujuan untuk saling berkomunikasi, berbagi sesuatu, berpendapat, menjalin komunikasi yang lebih intens. Sehingga banyak mengakibatkan timbulnya hubungan yang tidak sesuai dengan norma dan etika ditengah-tengah masyarakat. Tujuan diadakannya kegiatan literasi media adalah dalam rangka melindungi masyarakat (terutama pelajar) dari pengaruh negatif media sosial serta menciptakan audiens yang kritis. Kegiatan ini merupakan hal baru yang signifikansi dan daya Tarik tersendiri sehingga perlu dilakukan sosialisasi. Kegiatan tentang literasi media sosial dalam tataran konkret dilaksanakan dengan metode turun kelapangan yaitu mengunjungi sekolah. Tiga aspek dasar program literasi yaitu: Pertama, pembentukan aspek kognitif dalam pengetahuan menggunakan media sosial di kehidupan sehari-hari. Kedua, pembentukan aspek afektif dalam pembentukan pribadi yang bertanggungjawab sebagai generasi penerus bangsa. Ketiga, pembentukan aspek psikomotorik (keterampilan siswa) yang menjadikan siswa tanggap dan kreatif dan cerdas dalam menggunakan media sosial.
Intuitionistic fuzzy incidence graphs
Authors: Rashid Ismat , Nazeer Irfan , Rashid Tabasam 
Published: December 2021

Connectivity parameters have a crucial role in the study of different networks in the physical world. The notion of connectivity plays a key role in both theory and application of different graphs. In this article, a prime idea of connectivity concepts in intuitionistic fuzzy incidence graphs (IFIGs) with various examples is examined. IFIGs are essential in interconnection networks with influenced flows. Therefore, it is of paramount significance to inspect their connectivity characteristics. IFIGs is an extended structure of fuzzy incidence graphs (FIGs). Depending on the strength of a pair, this paper classifies three different types of pairs such as an α - strong, β - strong, and δ-pair. The benefit of this kind of stratification is that it helps to comprehend the fundamental structure of an IFIG thoroughly. The existence of a strong intuitionistic fuzzy incidence path among vertex, edge, and pair of an IFIG is established. Intuitionistic fuzzy incidence cut pairs (IFICPs) and intuitionistic fuzzy incidence trees (IFIT) are characterized using the idea of strong pairs (SPs). Complete IFIG is defined, and various other structural properties of IFIGs are also investigated. The proof that complete IFIG does not contain any δ-pair is also provided. A real-life application of these concepts related to the network of different computers is also provided.
EDUCAÇÃO PARA AS RELAÇÕES ETNICO-RACIAIS NAS AULAS DE EDUCAÇÃO FÍSICA: A CAPOEIRA COMO POSSIBILIDADE EDUCATIVA NOS DOCUMENTOS CURRICULARES OFICIAIS
Authors: Mentiacca Letícia de Freitas 
Published: December 2021

A Capoeira é uma das principais manifestações da cultura Afro-brasileira e, está difundida em vários países no mundo inteiro. Atualmente, contamos com políticas públicas que contemplam o estudo da História da África e dos Africanos, a luta dos negros no Brasil, a cultura negra brasileira e o negro na formação da sociedade nacional, resgatando a contribuição do povo negro nas áreas social, econômica e política pertinentes à História do Brasil. O objetivo deste trabalho é apresentar a capoeira como possibilidade educativa nas aulas de educação física escolar, priorizando os anos iniciais do ensino fundamental, conforme a Base Nacional Comum Curricular (BNCC) e o Referencial Curricular Gaúcho (RCG), entre outras legislações. Apresentaremos índices expressivos sobre a vulnerabilidade do negro no Brasil e como o racismo estrutura a sociedade em que vivemos. Atentando a problemática de que é necessário fomentarmos a educação para as relações étnico-raciais em nossas escolas, promovendo ações afirmativas e de valorização da cultura Afro-brasileira e Africana.
An Empirical Study of Consumer buying decision and Digital Marketing during COVID 19 Pandemic
Authors: Arora Dr. Richa , Nangia Dr. Richa 
Published: December 2021

The aim behind this research paper is to understand Impact of Digital Marketing during COVID 19 Pandemic on consumer buying decision. This research paper also confers about the four variables of digital marketing which are affecting the buying decision of the consumer. Both primary and secondary data has been collected for the current study. Data from primary sources collected through personal interviews, discussions with industry leaders and structured questionnaire. The research was also carried out on secondary sources like business journals, newspapers, magazines, periodicals, etc. SPSS 21 software has been used to analyse the data and linear regression analysis and multiple linear regression analysis techniques were used to determine the impact of each variable of digital marketing in influencing the buying decision making of the consumers.Findings of this research study determine the consistency of the independent variables, description of the product, pricing, marketing and promotions and distribution of the product on consumer buying decision. The following variables i.e.description of the product, marketing & promotions and distribution of the product has high significant impact on consumer buying decision.
Peran Subjective Well-Being dan Trust in The Employer terhadap Organizational Citizenship Behavior (OCB) Karyawan
Authors: Tentama Fatwa , Yuliantin Cita 
Published: December 2021

Organizational citizenship behaviour is one of the behaviours that can affect the company's success, so it is necessary to study the factors that can influence it. This study examines the effect of subjective well-being and trust in the employer on employee organizational citizenship behaviour. The population in this study were 110 permanent employees at an automotive company in Yogyakarta. The research sample was 70 employees with the characteristics of working in an automotive company, a minimum of one year of service, a permanent employee who did not work in the workshop. The sample selection was male and female with a nonprobability purposive sampling technique. The research instrument used was organizational citizenship behaviour, subjective well-being, and trust in the employer scales. Hypothesis testing using multiple linear regression analysis with SPSS V.21 program. Simultaneous analysis results show a significant effect of subjective well-being and trust on employee organizational citizenship behaviour. The partial analysis shows a very significant positive effect of subjective well-being on organizational citizenship behaviour and trust in the employer on organizational citizenship behaviour. Subjective well-being and trust in the employer contributed 49% to organizational citizenship behaviour. The amount of contribution given by subjective well-being contribution is 20.66%, and trust in the employer is 28.31%. Thus trust in the employer provides a more dominant contribution to organizational citizenship behaviour
Principais erros na fase pré-analítica de exames laboratoriais: uma revisão bibliográfica integrativa
Authors: Sousa Ana Claudia Nascimento , Rodrigues Junior Omero Martins 
Published: December 2021

Em um visão panorâmica dos serviços de diagnóstico promovidos pelos laboratórios, percebe-se que há uma relação de praticidade no auxílio do profissional da saúde a fim de elucidar o tratamento terapêutico aplicado no paciente, sendo necessário obedecer a legislação cabível para padronizar e proporcionar um controle de qualidade plausível dos resultados obtidos. A fase pré-analítica é a mais importante no processo de teste e envolve variáveis que não estão sob o controle do laboratório. Muito cuidado precisa ser tomado para examinar profundamente esta etapa da análise e manter um registro dos erros que surgem nela. Esta pesquisa tem como objetivo realizar um estudo sobre os principais erros da fase pré-analítica, enfatizando a coleta de materiais e de transporte, onde são encontrados os erros mais comuns, evidentes do processo no qual envolve em sua maioria, o trabalho manual. Desse modo, pode-se concluir que, a prática de manter um registro dos erros em todos os estágios da análise e, em seguida, desenvolver estratégias corretivas para sua prevenção pode libertar exponencialmente um laboratório de tais erros.
Qualidade microbiológica e características físico-químicas de maioneses caseiras servidas em lanchonetes da cidade de Manaus, Amazonas
Authors: Silva Luiz Henrique Guedes , Colares Janderley Almeida , Ramos José Antonio Ferreira , Moreno Matheus Nunes , Martim Salomão Rocha 
Published: December 2021

O consumo de maioneses caseiras vem crescendo devido as suas características nutricionais e sensoriais. Há poucos estudos reportando a qualidade sanitária e as características intrínsecas desses produtos servidos em estabelecimentos comerciais de Manaus-Amazonas. O presente estudo teve por objetivo realizar a análise microbiológica e as características físico-químicas de maioneses caseiras servidas em lanchonetes da cidade de Manaus, Amazonas. Dez amostras foram coletadas em lanchonetes das zonas centro-sul (ZCS), leste (ZL), norte (ZN), oeste ZO) e sul (ZS). Esses produtos foram avaliados quanto à presença de microrganismos (Coliformes a 45 °C, Escherichia coli e Salmonella sp.) e características físico-químicas (acidez titulável total e pH). As amostras apresentaram baixas contagens de coliformes a 45 °C (6,8 NMP/g a 21 NMP/g), ausência de E. coli e Salmonella sp. Os valores significativos de acidez (2,90 %) e pH (5,32) foram determinados nas amostras ZL1 e ZS1, respectivamente. As maioneses caseiras servidas em lanchonetes de Manaus atendem aos padrões microbiológicos vigentes. As avalições dos parâmetros de qualidade desses produtos devem ser contínuas, considerando a sua elevada aceitação na capital amazonense.
Results of salvage radiotherapy for prostate cancer after radical prostatectomy
Authors: Mozerova E. Ya. , Karabut R. Yu. , Lozhkov A. A. , Maksimovskaya A. Yu. , Sabelnikova Zh. E. , Sarycheva M. M. , Timokhina D. M. 
Published: December 2021

The aim of the study. To evaluate the results of radiation therapy for recurrent prostate cancer after radical prostatectomy.Methods. The analysis of medical records data of 60 patients with recurrent prostate cancer after radical prostatectomy (RP) was performed.Results. Biochemical control was achieved in 55 (92.0%) patients, PSA progression – in 3 (5.0%) and generalization – in 2 (3.0%) patients. Grade I–II cystitis developed in 25 patients (42.0%), grade I–II rectitis – in 7 (11.0%), late hemorrhagic cystitis was noted in 4 (7.0%) patients, late hemorrhagic rectitis – in 2 (3.3%) ones.Сonclusions. Salvage radiation therapy for recurrent prostate cancer after radical prostatectomy is an important treatment method that allows to achieve biochemical control with acceptable toxicity.
Arbuscular mycorrhizal fungi improve the growth of pioneer tree species of tropical forests on savanna and tropical rainforest soils under nursery conditions
Authors: Álvarez-Lopeztello Jonás , Del Castillo Rafael F. , Robles Celerino , Hernández-Cuevas Laura V. 
Published: December 2021

Background: Tropical rainforests and savannas are often spatially distributed at close distances. The combined effects of soil type and arbuscular mycorrhizal fungi (AMF) might contribute to explain the preference of tropical rainforest tree species for forest areas over those of savannas. However, few studies have examined such effects on pioneer tropical tree species.
Objective: Evaluate the effects of soil type and inoculation with an AMF consortium on the growth of seedlings of pioneer tree species of tropical rainforest.
Methods: A factorial 2 x 2 experiment was conducted to evaluate the role of soil type (rainforest or savanna) and native AMF consortium on growth (height and stem diameter) of four native pioneer tree seedling species under tree nursery conditions.
Results and conclusions: The highest growth was detected on rainforest soils inoculated with AMF. Uninoculated plants growing on savanna soils rendered the lowest performance. AMF inoculation could be a valuable procedure in ecological restoration projects of tropical forests.
Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study
Authors: Wang Wenrui , Zhou Mengyang , Xu Yang , Peng Wei , Zhang Shiwen , Li Rongjie , Zhang Han , Zhang Hui , Cheng Shumin , Wang Youjing , Wei Xinyu , Yue Chengxu , Yang Qingling , Chen Changjie 
Published: December 2021

Multidrug resistance (MDR) is a serious problem during cancer therapy. The purpose of the present study was to formulate D-α-Tocopheryl polyethylene glycol 1000 succinate-resveratrol-solid lipid nanoparticles (TPGS-Res-SLNs) to improve its therapeutic efficacy against breast cancer. In this study, the solvent injection method was used to prepare the TPGS-Res-SLNs. It was found that the TPGS-Res-SLNs exhibited zeta potential and drug-loading of −25.6 ± 1.3 mV and 32.4 ± 2.6%, respectively. Therefore, it was evident that the TPGS-Res-SLNs can increase cellular uptake of chemotherapeutic drugs, induce mitochondrial dysfunction, and augment tumor treatment efficiency by inducing apoptosis. Moreover, it was found that SKBR3/PR cells treated with TPGS-Res-SLNs exhibited significant inhibition of cell migration and invasion, as compared with free resveratrol. In addition, results from in vivo SKBR3/PR xenograft tumor models revealed that TPGS-Res-SLNs has better efficacy in promoting apoptosis of tumor cells owing to high therapeutic outcomes on tumors when compared with the efficacy of free resveratrol. In conclusion, the findings of the present study indicate significant potential for use of TPGS-Res-SLNs as an efficient drug delivery vehicle to overcome drug resistance in breast cancer therapy.
A Label-Free Immunosensor Based on Gold Nanoparticles/Thionine for Sensitive Detection of PAT Protein in Genetically Modified Crops
Authors: Yang Qianwen , Wang Yu , Liu Xiaofeng , Liu Hua , Bao Huifang , Wang Jinbin , Zeng Haijuan 
Published: December 2021

Genetically modified (GM) crops containing phosphinothricin acetyltransferase (PAT) protein has been widely planted worldwide. The development of a rapid method for detecting PAT protein is of great importance to food supervision. In this study, a simple label-free electrochemical immunosensor for the ultrasensitive detection of PAT protein was constructed using thionine (Thi)/gold nanoparticles (AuNPs) as signal amplification molecules and electrochemically active substances. Under optimum conditions, the limits of detection of the sensor for soybean A2704-12 and maize BT-176 were 0.02% and 0.03%, respectively. The sensor could detect crops containing PAT protein and had no cross-reaction with other proteins. After storage at 4°C for 33 days, the sensor still retained 82.5% of the original signal, with a relative standard deviation (RSD) of 0.92%. The recoveries of the sensor for soybean A2704-12 and maize BT-176 were 85%–108% and 98%–113%, respectively. The developed PAT-target immunosensor with high sensitivity, specificity, and satisfactory reproducibility and accuracy will be a useful tool in the trace screening of GM crops. Moreover, this design concept can be extended to other proteins by simply changing the antibody.
Effect of Coronary Disease Characteristics on Prognostic Relevance of Residual Ischemia After Stent Implantation
Authors: Yang Seokhun , Zhang Jinlong , Hwang Doyeon , Lee Joo Myung , Nam Chang-Wook , Shin Eun-Seok , Doh Joon-Hyung , Hoshino Masahiro , Hamaya Rikuta , Kanaji Yoshihisa , Murai Tadashi , Zhang Jun-Jie , Ye Fei , Li Xiaobo , Ge Zhen , Chen Shao-Liang , Kakuta Tsunekazu , Koo Bon-Kwon 
Published: December 2021

Objectives: We investigated the influence of coronary disease characteristics on prognostic implications of residual ischemia after coronary stent implantation.Methods: This study included 1,476 patients with drug-eluting stent implantation and available pre- and post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) measurements. Residual ischemia was defined as post-PCI FFR ≤ 0.80. Coronary disease characteristics with significant interaction hazard ratios (HRs) for clinical outcomes with residual ischemia were defined as interaction characteristics with residual ischemia (ICwRI). The primary outcome was target vessel failure (TVF)—a composite of cardiac death, target vessel myocardial infarction, and target vessel revascularization—at 2 years.Results: The mean pre- and post-PCI FFR were 0.68 ± 0.11 and 0.87 ± 0.07, respectively. During the median follow-up duration of 2.0 years, the cumulative incidence of TVF was 6.1%. The 203 vessels (13.8%) with residual ischemia had higher risks of TVF compared to that for post-PCI FFR &gt;0.80 (P &lt; 0.001). ICwRI with a significant interaction HR with residual ischemia included pre-PCI SYNTAX score &gt;17 and pre-PCI FFR ≤ 0.62. Each ICwRI had a direct prognostic effect not mediated by residual ischemia. The association between an increased TVF risk and residual ischemia was significant in patients with 0 or 1 ICwRI [hazard ratio (HR) 3.25, 95% confidence interval (CI) 1.90–5.57, P &lt; 0.001] but not in those with 2 ICwRI (HR 0.47, 95% CI 0.14–1.64, P = 0.24). Among patients with post-PCI FFR &gt;0.80, those with 2 ICwRI showed similar TVF risks to those with residual ischemia (HR 1.55, 95% CI 0.79–3.02, P = 0.20).Conclusions: Coronary disease characteristics including pre-PCI SYNTAX score and pre-PCI FFR affected the prognostic implications of residual ischemia. The prognostic relevance of residual ischemia was attenuated in patients with multiple interacting characteristics.
Multiple Tolerization Subtractive Immunization (MTSI) Protocol: Effects on Mice and Monoclonal Antibody Specificity
Authors: de Lima Fontes Marina , Neves Franciny Mara de Lima , Santos Kelvin Sousa , Fusco-Almeida Ana Marisa , Giannini Maria José Soares Mendes , Felisbino Sergio Luis , Deffune Elenice , Moroz Andrei 
Published: December 2021

Monoclonal antibodies (mAbs) have been a valuable tool to elucidate several biological processes, such as stem cell differentiation and cancer, and contributed to virtually all areas of biomedical sciences. Yet, it remains a challenge to obtain mAbs specific to poorly expressed epitopes, or to epitopes that are actually involved in important biological phenomena, such as cell differentiation and metastasis. Drug-induced subtractive immunization, and recently the multiple tolerization subtractive immunization (MTSI) technique, reported by our group, have the potential to level up the field, as they direct the host´s immune response towards these epitopes. However, due to cyclophosphamide (CY) treatment, high mice mortality can be observed, and only a few data are available on how these techniques affect the immune system of mice. Tolerogen and immunogen cells, RWPE-1 and PC-3 cells, respectively, were individually seeded at 2 × 104 cells/cm2, and then adjusted to 2 × 106 cells per mouse before immunization, which was conducted in a subtractive approach (MTSI) with CY. Immunosuppression of mice was recorded via total white blood counting, as well the reactivity of circulating polyclonal antibodies (pAbs). General parameters, including weight, physical appearance, and behavior on mice subjected to three different concentrations of CY were recorded. mAbs were obtained using classical hybridoma techniques, using the spleen of immunized mice. After purification, antibodies were characterized by Western blotting, and Indirect immunofluorescence. In conclusion, all CY dosage were efficient in creating an immunosuppression state, but only the 100 mg/kg body weight was feasible, as the others resulted in extensive mice mortality. pAbs obtained in the peripheral blood of mice showed more reactivity towards tumor cells. MAbs 2-7A50 and 2-5C11 recognized antigens from tumor cells, but not from their non-tumor counterparts, as shown in western blotting and immunofluorescence assays. MTSI technique was successful in generating mAbs that recognize tumor-specific antigens.