bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Patients With Locally Advanced Gastric Cancer Who May Benefit From Adjuvant Chemoradiotherapy After D2 dissection: A Propensity Score Matching Analysis
Authors: Wang Shu-Bei , Qi Wei-Xiang , Chen Jia-Yi , Xu Cheng , Cao Wei-Guo , Cai Rong , Cao Lu , Cai Gang 
Published: April 2021

BackgroundOne of the most controversial areas in gastrointestinal oncology is the benefit of postoperative chemoradiotherapy (CRT) over chemotherapy (CT) alone after D2 dissection of locally advanced gastric cancer (LAGC). We aimed to identify the LAGC patients who may benefit from adjuvant CRT.MethodsWe analyzed retrospectively 188 patients receiving radical gastrectomy with D2 dissection for LAGC in our hospital. Patients were divided into two balanced groups by using propensity score matching: CRT group (n = 94) received adjuvant CRT, and CT group received adjuvant CT alone.ResultsAt a median follow-up of 27.10 months, 188 patients developed 79 first recurrence events (36 in CRT group and 43 in CT group). Our results showed that adjuvant CRT significantly decreased the risk of developing local regional recurrence (LRR) when compared to CT alone (14.9% vs. 25.5%, p = 0.044), while the estimated 3-year disease-free survival (DFS) was comparable between the CRT and CT groups (59.3% vs. 50.9%, p = 0.239). In the subgroup analysis, a significantly decreased LRR rate was also observed in LAGC patients with N1-3a stage after adjuvant CRT (p = 0.046), but not for N3b. Para-aortic lymph nodes (station No. 16) were the most frequent sites of LRR. After receiving radiotherapy, recurrence of 16 a2 region and 16 b1 region were significantly deceased (p = 0.026 and p = 0.044, respectively). Patients who received irradiation more than 4 months after surgery showed an increased risk of LRR (p = 0.022).ConclusionsThis study showed that adjuvant CRT significantly reduced LRR after D2 dissection of LAGC. Early initiation of adjuvant RT with clinical target volume encompassing a2 and b1 regions of para-aortic lymph nodes is recommended for pN1-3a patients after D2 dissection.
Electroacupuncture Regularizes Gastric Contraction and Reduces Apoptosis of Interstitial Cells of Cajal in Diabetic Rats
Authors: Wang Hongcai , Zhao Kaile , Shi Ning , Niu Qiong , Liu Chengxia , Chen Yan 
Published: April 2021

Background/AimsGastric dysmotility is a frequent complication among patients with diabetes mellitus. Electroacupuncture (EA) has been empirically used to relieve gastrointestinal symptoms. The aims of this study were to investigate the effects of EA on gastric contraction and the mechanisms of interstitial cells of Cajal (ICC) involved.Materials and MethodsMale Sprague–Dawley rats were randomized into the normal control, diabetes (DM), diabetic and sham EA (DM + SEA), diabetic and low-frequency EA (DM + LEA), and diabetic and high-frequency EA (DM + HEA) groups. Diabetic models were established and then treated with EA for 8 weeks. Body weight and blood glucose were recorded every 2 weeks. The spontaneous contractions of distal gastric strips were analyzed. Immunostaining and RT-PCR were used to test the apoptotic ICC, IGF-1/IGF-1R, and Nrf2/HO-1 pathways.ResultsThe body weight in the DM + LEA and DM + HEA groups were increased compared with that of the DM group, though there was no effect on the blood glucose. The gastric contractions were obviously disordered in the DM group, but EA could regularize the contractions. The number of apoptotic ICC was dramatically increased in the DM group, but reduced with EA treatment. Meanwhile, the IGF-1/IGF-1R pathway was verified to be significantly altered in diabetic rats. The Nrf2/HO-1 pathway was not significantly increased in the DM group. EA with different frequencies efficiently improved the expression of IGF-1/IGF-1R signaling and activated the Nrf2/HO-1 pathway.ConclusionEA could improve gastric motility dysfunction and attenuate ICC apoptosis possibly through the regulation of IGF-1/IGF-1R and Nrf2/HO-1 pathways. EA may be a potential therapeutic method for diabetic gastric motility dysfunction.
Effects of Whole Body Electrostimulation Associated With Body Weight Training on Functional Capacity and Body Composition in Inactive Older People
Authors: Evangelista Alexandre Lopes , Alonso Angelica Castilho , Ritti-Dias Raphael M. , Barros Bruna Massaroto , Souza Cleison Rodrigues de , Braz Tiago Volpi , Bocalini Danilo Sales , Greve Julia Maria D'andréa 
Published: April 2021

Objective: To analyze the effects of whole body electrostimulation (WB-EMS) with body weight training on functional fitness and body composition of older men.Methods: Twenty physically inactive older men were randomized into: Control group (control), performed the body weight exercise training wearing electrostimulation clothing, but without receiving electrical current stimuli (n = 10), and body weight associated with whole body electrostimulation group (BW+WB-EMS), performed the body weight exercise training wearing electrostimulation clothing plus whole body electrostimulation (n = 10). The training sessions were performed twice a week for 6 weeks and included eight exercises using body weight, performed in two sets of eight repetitions. Physical function was assessed using a battery composed of seven tests, six derived from the Senior fitness test and a handgrip strength test. We also measured the muscle thickness (MT) of the biceps and triceps brachii and vastus lateralis.Results: The BW+WB-EMS group presented increased (p &lt; 0.05) performance in the 30-s chair stand test (10.2 ± 3.3 vs. 13.8 ± 5.0 reps), arm curl (16.6 ± 3.9 vs. 19.9 ± 6.1 reps), 6-min walk test (402 ± 96 vs. 500 ± 104 m), and handgrip strength test (30 ± 11 vs. 32 ± 11 kgf). The BW+WB-EMS group also presented increased MT (p &lt; 0.05) in the biceps brachii (17.7 ± 3.0 vs. 21.4 ± 3.4 mm), triceps brachial (14.7 ± 3.6 vs. 17.5 ± 4.1 mm), and vastus lateralis muscles (15.1 ± 2.6 vs. 18.6 ± 4.3 mm). Moderate correlations were found in arm curl (p = 0.011, r = 0.552) but not handgrip strength (p = 0.053, r = 0.439) with changes in the biceps MT. Moderate changes in the 6-min walk distance were significantly correlated with changes in vastus lateralis MT (p = 0.036, r = 0.471). There was a moderate correlation between the changes in the 30-s chair stand test (p = 0.006, r = 0.589) and changes in the vastus lateralis MT. Furthermore, although a moderate correlation (r = 0.438) was found between triceps MT and handgrip strength no significant difference (p = 0.053) was reported. Additionally, there were no statistical differences in any parameters for the control group.Conclusion: WB-EMS with body weight training increased functional fitness and MT in physically inactive older men.
An Emotion Regulation and Impulse Control (ERIC) Intervention for Vulnerable Young People: A Multi-Sectoral Pilot Study
Authors: Hall Kate , Youssef George , Simpson Angela , Sloan Elise , Graeme Liam , Perry Natasha , Moulding Richard , Baker Amanda L. , Beck Alison K. , Staiger Petra K. 
Published: April 2021

Objective: There is a demonstrated link between the mental health and substance use comorbidities experienced by young adults, however the vast majority of psychological interventions are disorder specific. Novel psychological approaches that adequately acknowledge the psychosocial complexity and transdiagnostic needs of vulnerable young people are urgently needed. A modular skills-based program for emotion regulation and impulse control (ERIC) addresses this gap. The current one armed open trial was designed to evaluate the impact that 12 weeks exposure to ERIC alongside usual care had on young people's ability to regulate emotions, as well as examine potential moderating mechanisms.Methods: Seventy nine young people (50.6% male; M = 19.30; SD = 2.94) were enrolled to the 12 week intervention period. Twenty one practitioners from youth and community health services delivered relevant ERIC modules adjunct to usual care. Linear mixed effects regression (with random intercept) was used to examine change over time across the primary outcome of emotion dysregulation and secondary outcomes of depression, anxiety, stress, experiential avoidance and mindfulness. Moderation analyses were conducted to test whether the magnitude of change in emotion dysregulation moderated change over time in secondary outcomes.Results: Analyses revealed significant improvement in the primary outcome of emotion dysregulation with a moderate effect size (Mean Change = −10.24, 95% CI (−14.41, −6.06; Cohen's dav = −0.53), in addition to decreases in the secondary outcomes of depression, anxiety, stress and experiential avoidance. No improvements in mindfulness were reported. Moderation analyses revealed that the residualised change over time in emotion dysregulation moderated the change over time in symptoms of distress, depression, anxiety, stress, experiential avoidance, and mindfulness.Conclusion: Reductions in the severity of emotion dysregulation, depression, anxiety, stress and experiential avoidance are promising, and were evident despite the complexity of the participants and the diversity of the service setting. The improvements found in each outcome were only observed for those young people whose emotion regulation also improved, providing preliminary evidence for the role of emotion regulation as a key treatment target in this population.
Cultural Adaptation of Community Informant Tool for Detection of Maternal Depression in Rural Pakistan
Authors: Mohsin Shamaila , Atif Najia , Rabbani Waqas , Tariq Ahmaren , Khan Shahzad Ali , Tariq Mahjabeen , Sikander Siham 
Published: April 2021

Background: Evidence indicates that mental health issues like depression, epilepsy, and substance misuse can be detected with reasonable accuracy in resource-poor settings. The Community Informant Detection Tool (CIDT) is one such approach used for detecting mental health problems, including depression. We adapted this community informant approach for detecting maternal depression in Pakistan.Methods: Adaptation of Community Informant Detection Tool for Maternal Depression (CIDT-MD) involved five steps. First, a scoping review of the literature was conducted to select an appropriate tool for adaptation. Second, in-depth interviews were conducted to explore the idioms of depression and distress, perceived causes, and the effects of maternal depression among currently depressed and recovered mothers (n = 11), mothers in law (n = 6), and Primary Care Providers (Primary Care Physicians and Lady Health Supervisors) (n = 6). Third, case vignettes and illustrations were created with input from a panel of mental health experts, incorporating the idioms of depression and distress used, causes, and effects for each symptom described. Fourth, to assess the comprehensibility of the illustrations and level of understanding, Focus Group Discussions (n = 4) were done with purposely selected community health workers (Lady Health Workers and Lay Peers, n = 28) trained in delivering maternal depression intervention. The final step was reflection and inputs by a panel of mental health experts on all steps to finalize the content of the tool.Results: Context-specific cultural adaptation in the presentation and format of CIDT-MD was conducted successfully. Lady Health Workers (LHW) and Lay Peers (LP) were found to be the most appropriate persons to use the tool and function as the informants. The adapted tool with all its vignettes and illustrations was found to be easily understandable, comprehensible, and culturally appropriate, meaningful, and contextually relevant by the community health workers and peers working in the relevant settings. They easily relate to and identify potentially depressed such women lining up with the tool. Lastly, the coding of the tool was found easy to follow as well.Conclusion: The Community Informant Detection Tool for Maternal Depression (CIDT-MD) is a culturally acceptable, easy to use, and comprehensible tool for detecting maternal depression in community settings of Pakistan. The community informants found the content and approach highly relevant to the local needs.
Case Report: Hidden Oral Squamous Cell Carcinoma in Oral Somatic Symptom Disorder
Authors: Suga Takayuki , Tu Trang Thi Huyen , Takenoshita Miho , Mikuzuki Lou , Umezaki Yojiro , Shimamoto Hiroaki , Michi Yasuyuki , Hong Chaoli , Abiko Yoshihiro , Ikeda Tohru , Uzawa Narikazu , Harada Hiroyuki , Toyofuku Akira 
Published: April 2021

Background: Burning mouth syndrome (BMS) is a common condition of predominant oral pain without evident cause, that maxillofacial surgeons and otolaryngologists often refer to psychiatrists as somatic symptom disorder. In very rare cases, its typical burning symptom mimics those of other diseases in which serious fatal comorbidities may be missed. We encountered three rare cases of oral squamous cell carcinoma (OSCC) with the first symptom of burning tongue.Case Presentation: Case 1: A 68-year-old woman had burning pain on the left lingual margin for 8 years. Antidepressant treatment was not efficacious. Cytology and biopsy revealed OSCC. Case 2: A 70-year-old man had burning sensation and paralysis of the tongue for 6 months. Magnetic resonance imaging (MRI) revealed a 37 × 23-mm mass under the floor of the mouth and enlargement of lymph nodes on both sides. Case 3: A 90-year-old man had burning sensation of the tongue for 1 year. MRI revealed a 12 × 12-mm mass on the mandible with bone absorption.Conclusion: This case series suggests that psychiatrists must always be careful in regarding BMS as somatic symptom disorder and be cautious of the possibility of OSCC, especially in elderly patients.
The Fast Track FIT study: diagnostic accuracy of faecal immunochemical test for haemoglobin in patients with suspected colorectal cancer
Authors: Turvill James L , Turnock Daniel , Cottingham Dan , Haritakis Monica , Jeffery Laura , Girdwood Annabelle , Hearfield Tom , Mitchell Alex , Keding Ada 
Published: April 2021

BackgroundThe faecal immunochemical test (FIT) is now available to support clinicians in the assessment of patients at low risk of colorectal cancer (CRC) and within the bowel cancer screening programme.AimTo determine the diagnostic accuracy of FIT for CRC and clinically significant disease in patients referred as they were judged by their GP to fulfil National Institute for Health and Care Excellence guideline 12 (NG12) criteria for suspected CRC.Design and settingPatients referred from primary care with suspected CRC, meeting NG12 criteria, to 12 secondary care providers in Yorkshire and Humber were asked to complete a FIT before investigation.MethodThe diagnostic accuracy of FIT based on final diagnosis was evaluated using receiver operating characteristics analysis. This permitted a statistically optimal cut-off value for FIT to be determined based on the maximisation of sensitivity and specificity. Clinicians and patients were blinded to the FIT results.ResultsIn total, 5040 patients were fully evaluated and CRC was detected in 151 (3.0%). An optimal cut-off value of 19 µg Hb/g faeces for CRC was determined, giving a sensitivity of 85.4% (95% confidence interval [CI] = 78.8% to 90.6%) and specificity of 85.2% (95% CI = 84.1% to 86.2%). The negative predictive value at this cut-off value was 99.5% (95% CI = 99.2% to 99.7%) and the positive predictive value 15.1% (95% CI = 12.8% to 17.7%). Sensitivity and specificity of FIT for CRC and significant premalignant polyps at this cut-off value were 62.9% (95% CI = 57.5% to 68.0%) and 86.4% (95% CI = 85.4% to 87.4%), respectively; and when including all organic enteric disease were 35.7% (95% CI = 32.9% to 38.5%) and 88.6% (95% CI = 87.5% to 89.6%), respectively.ConclusionFIT used in patients fulfilling NG12 criteria should allow for a more personalised CRC risk assessment. FIT should permit effective, patient-centred decision-making to inform the need for, type, and timing of further investigation.
METHODOLOGICAL ASPECTS OF SELECTION OF THE OPTIMAL MOMENT OF MAKING TRANSACTIONS AT THE SECURITIES MARKET ON THE BASIS OF TECHNICAL ANALYSIS
Authors: Aksenov S. Yu. , Vyzhitovich A. M. 
Published: April 2021

The versatility of technical analysis allows developing of the trading strategy for every desire. Anyway, a price movement of any financial instrument can be divided into periods of consolidation and trends. Significant price change of assets occurs during trend periods, so it’s better to choose those methods of technical analysis that are able to predict the points of origin of the directional movement. At the present time the progress and joint applying of technical analysis and Information Technology give a possibility to dramatically simplify the routine operations of analytics and investors. The article provides a brief overview of the existing methods of technical analysis and proposes a methodology for choosing the optimal moment for making trades in the security market based on them. Reviewed algorithms and methods based on modern Information technologies that allow to automate routine tasks and processes in short time. This amount of market data that cannot be analyzed by a human.
PERSONAL KNOWLEDGE VERSUS DISTANCE LEARNING
Authors: Sukhanova N. P. , Rodicheva I. S. 
Published: April 2021

The modern educational process is focused on the training of a specialist who is able to think critically and creatively solve problematic situations, constantly raising the level of his education. Education as the most important social institution reacts sharply to the processes taking place in society. Actively developing distance learning is quite popular today, but there are different kinds of questions related to its implementation and the significance of a personal example, personal contacts in the learning process is one of the questions that is analyzed in this article. Would the distance learning be complete if it was deprived of subjectivity by definition? The educational system is understood to be a tradition in the article. The authors stress two types of traditions: verbalized and non-verbalized. The specificity of pedagogical activity does not allow many of its significant components to be explicated. The attention is focused on non-verbalized traditions existing in the form of implicit knowledge. Specific examples (V.I. Vernadsky, V.V. Dokuchaev, P.V. Ototsky) reveal the necessity of personal knowledge in the educational process. The article concludes that personal communication between the lecturer and the student is necessary as a conscious movement against deindividuation in modern society.
Structural and optical characteristic of 1-(4-Methylsulfonyl Phenyl)-3-(4-n, n Dimethyl (amino Phenyl)-2-Propen- 1-One (MSPPP) Chalcone doped ZnO nanoparticles
Authors: F. Attia Mohana , A. Elbadawi Abdelrahman 
Published: April 2021

The purpose of this paper is to investigate the structural and optical characteristics of 1-(4-Methylsulfonyl Phenyl)-3-(4-n, n Dimethyl (amino Phenyl)-2-Propen- 1-One (MSPPP) Chalcone doped in ZnO nanoparticles. Part of the aim is to study the characterization of chalcone doped ZnO nanoparticles by several techniques such as X-ray diffraction, Scanning electron microscope, FTIR spectroscopy, and diffuse reflection spectra. All doped samples showed a hexagonal wurtzite structure. This study has shown that the crystallite size of pure ZnO varied from 23.50 to 27.45 nm and when increasing the chalcone percentage by 0.5 and 1.5%, has increased the crystallite sizes in the range of 33.40–33.80 nm and 33.80–36.20 nm, respectively. The value of the energy gap (Eg) for ZnO nanoparticles was 3.14 eV. For 0.5 and 1.5% chalcone doped ZnO, the energy gap decreased by an order of magnitude 0.16 eV.
Efektivitas Metode Talaqqi Pada Halaqah Tarbiyah Di Wahdah Islamiyah Sulawesi Tenggara Dan Analisis Metode Talaqqi Dalam Kitab ‘Uddatu At Talabi Binajmi Manhaj At Talaqqi Wa Al Adab
Authors: Shamsul Mariyanto Nur , Kato Iskandar , Hanufi Samsuddin La 
Published: April 2021

Talaqqi adalah satu bentuk metode pendidikan dalam islam, untuk belajar ilmu agama secara langsung kepada guru yang mempunyai kompetensi ilmu, tsiqah, dhabit dan mempunyai sanad keilmuan yang muttashil dan dilakukan secara khusus dengan mengumpulkan beberapa sistem dan model pembelajaran untuk menjadikan penuntut ilmu memiliki adab islami dan memahami, mengamalkan serta mendakwahkan ilmunya. Tulisan ini adalah hasil penelitian tentang efektivitas metode talaqqi, yang dianalisis dari pelaksanaan metode talaqqi pada halaqah tarbiyah Wahdah Islamiyah Sulawesi Tenggara dan metode talaqqi dalam kitab ‘Uddatu at Talabi Binajmi Manhaj at Talaqqi wa al Adab dengan menggabungkan metode survey terhadap halaqah tarbiyah di Wahdah Islamiyah Sulawesi Tenggara dan menganalisis literatur terhadap kitab ‘Uddatu at Talabi Binajmi Manhaj at Talaqqi wa al Adab karya Syaikh Dr. Abdullah Bin Muhammad Sufyan Al Hakimi dengan hasil penelitian dimana efektivitas pelaksanaan metode pendidikan talaqqi pada halaqah tarbiyah di Wahdah Islamiyah Sulawesi Tenggara belum tercapai dan metode pendidikan talaqqi yang terdapat pada kitab ‘Uddatu at Talabi Binajmi Manhaj at Talaqqi wa al Adab adalah bergabung dengan halaqah pendidikan adab, Membangun sistem pendidikan Adab, menetap di masjid selama talaqqi, Mulazamah, Meningkatkan kapasitas menghafal, menghormati guru. Hasil penelitian ini adalah untuk mencapai efektivitas pelaksanaan tarbiyah di wahdah islamiyah sulawesi tenggara maka harus dilakukan kombinasi antara standar operasional pelaksanaan tarbiyah di wahdah islamiyah dan konsep manhaj talaqqi dalam kitab “Uddatu at talabi binazmi manhaj at talaqqi wa al adabi
Ameliorative effects of Withania coagulans and Metformin on Ovarian morphology in Polycystic ovarian disease induced rats
Authors: Hira Ayaz  , Abdul Samad  , Aiman Farogh Anjum  , Nasar Abbas Shamsi  , Sidra Arshad  , Mahvash Khan  
Published: April 2021

Background: Various medicinal herb plants are being used in place of metformin for treatment of polycystic ovarian disease for their less harmful effects. Withania coagulans (WC) is a herb known for its insulin sensitizing and weight reducing properties. The present study was done to determine the influence of aqueous extract of Withania coagulans (aqWC) and metformin on ovarian weight and ovarian folliculogenesis in polycystic ovarian disease-induced rats.
Material and Methods: An experimental animal study was carried out at the Physiology Department of Islamic International Medical College, Rawalpindi from April 2016 to March 2017. Forty female Sprague Dawley rats were divided initially into two groups. Group A (Normal Control) and Disease induced group. Standardized laboratory diet was fed to Group A while the disease induced group was given standardized laboratory diet and letrozole solution orally (1mg/kg) for 21 days to induce Polycystic ovary syndrome, which was established by observing estrous cycle of rats. Disease induced group was then split into group B (PCOS control), C (Aqueous Withania coagulans treated) and D (Metformin treated) and observed after 14 days. Groups A and B underwent ovarian dissection after 21 days and groups C and D underwent dissection at the end of experiment (after 35 days). Independent sample t-test was used for the comparison between the control and disease induced group.
Results: Group B showed a significant increase in ovarian weight in comparison to group A rats (P < .05). Treatment with Withania coagulans and metformin significantly decreased ovarian weight (P < .05) and increased primary, Graafian, antral follicular count and corpus luteum along with reduction in cystic follicular count in letrozole-induced polycystic ovarian disease rats. Improved folliculogenesis was also observed in the same groups (groups C & D).
Conclusions: Withania coagulans can be a substitute for improvement of ovarian follicular development in polycystic ovarian disease.