bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation–Induced Cardiovascular Consequences in Early Metabolic Impairment
Authors: Dwaib Haneen S. , Ajouz Ghina , AlZaim Ibrahim , Rafeh Rim , Mroueh Ali , Mougharbil Nahed , Ragi Marie‐Elizabeth , Refaat Marwan , Obeid Omar , El‐Yazbi Ahmed F. 
Published: December 2021

Background
The complexity of the interaction between metabolic dysfunction and cardiovascular complications has long been recognized to extend beyond simple perturbations of blood glucose levels. Yet, structured interventions targeting the root pathologies are not forthcoming. Growing evidence implicates the inflammatory changes occurring in perivascular adipose tissue (PVAT) as early instigators of cardiovascular deterioration.

Methods and Results
We used a nonobese prediabetic rat model with localized PVAT inflammation induced by hypercaloric diet feeding, which dilutes inorganic phosphorus (Pi) to energy ratio by 50%, to investigate whether Pi supplementation ameliorates the early metabolic impairment. A 12‐week Pi supplementation at concentrations equivalent to and twice as much as that in the control diet was performed. The localized PVAT inflammation was reversed in a dose‐dependent manner. The increased expression of UCP1 (uncoupling protein1), HIF‐1α (hypoxia inducible factor‐1α), and IL‐1β (interleukin‐1β), representing the hallmark of PVAT inflammation in this rat model, were reversed, with normalization of PVAT macrophage polarization. Pi supplementation restored the metabolic efficiency consistent with its putative role as an UCP1 inhibitor. Alongside, parasympathetic autonomic and cerebrovascular dysfunction function observed in the prediabetic model was reversed, together with the mitigation of multiple molecular and histological cardiovascular damage markers. Significantly, a Pi‐deficient control diet neither induced PVAT inflammation nor cardiovascular dysfunction, whereas Pi reinstatement in the diet after a 10‐week exposure to a hypercaloric low‐Pi diet ameliorated the dysfunction.

Conclusions
Our present results propose Pi supplementation as a simple intervention to reverse PVAT inflammation and its early cardiovascular consequences, possibly through the interference with hypercaloric‐induced increase in UCP1 expression/activity.
Clinical and Imaging Indicators of Hemorrhagic Transformation in Acute Ischemic Stroke After Endovascular Thrombectomy
Authors: Tian Bing , Tian Xia , Shi Zhang , Peng Wenjia , Zhang Xuefeng , Yang Pengfei , Li Zifu , Zhang Xiaoxi , Lou Min , Yin Congguo , Zhang Yongwei , Lu Jianping , Liu Jianmin ,   for the DIRECT-MT Investigators
Published: December 2021

Background:
Prior studies have investigated the clinical and imaging factors for hemorrhagic transformation (HT), especially symptomatic intracranial hemorrhage (sICH); however, whether alteplase increases the risk of HT after endovascular thrombectomy (EVT) is unknown. This study aimed to assess clinical and imaging features associated with HT, sICH, and parenchymal hematoma (PH) in patients with acute ischemic stroke after EVT, with and without intravenous alteplase in DIRECT-MT (Direct Intraarterial Thrombectomy to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals: a Multicenter Randomized Clinical Trial).

Methods:
The DIRECT-MT trial is a randomized trial of EVT alone versus intravenous thrombolysis combined with EVT. HT, sICH, and PH was evaluated on follow-up computed tomography. Multivariable ordinal logistic regression analysis was used to test the association of stepwise selected determinants with HT, sICH, and PH.

Results:
In total, 633 patients were analyzed; 261 (41.2%) had HT; 34 (5.4%) had sICH; and 85 (13.4%) had PH. The median age was 69, and 56.7% were men. The median National Institutes of Health Stroke Scale score was 18, and 320 patients were in combination-therapy group. Symptomatic intracranial hemorrhage was associated with higher baseline National Institutes of Health Stroke Scale score (adjusted odds ratio [OR], 1.06 [95% CI, 1.10–1.12]) and higher glucose level at hospital arrival (adjusted OR, 1.14 [95% CI, 1.00–1.29]). No association was found between alteplase treatment and HT, sICH, or PH. The independent predictor of sICH was higher baseline National Institutes of Health Stroke Scale score (adjusted OR, 1.09 [95% CI, 1.01–1.18]) in EVT alone group, and history of anticoagulant drugs (adjusted OR, 3.75 [95% CI, 1.07–13.06]), higher glucose level at hospital arrival (adjusted OR, 1.19 [95% CI, 1.03–1.38]), >3 passes of device (adjusted OR, 4.42 [95% CI, 1.36–14.32]) in combination-therapy group.

Conclusions:
In DIRECT-MT, independent predictors of sICH were baseline National Institutes of Health Stroke Scale score and glucose level at hospital arrival. Alteplase treatment did not increase the risk of HT, sICH, or PH after EVT. The independent predictor of sICH was different in EVT alone group and combination-therapy group.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03469206.
Ottoman Archival Documents on the Shrines of Karbala, Najaf, and the Hejaz (1660s-1720s): Endowment Wars, the Spoils System, and Iranian Pilgrims
Authors: Güngörürler Selim 
Published: December 2021

Abstract
This study introduces and publishes an array of Ottoman archival documents on the shrines of Ahl al-Bayt imams in Iraq, the endowments dedicated to these shrines, and the Shiite-Iranian pilgrims visiting these sites as well as the Kaaba and the shrine of Muhammad in the Hejaz. Focusing on the later seventeenth and the early eighteenth centuries, it discusses the political-economic function of Islamic endowments, interconfessional contacts resulting from pilgrimage by Shiites in Sunni territory, and the potential use of Ottoman archives to enrich our knowledge on trans-Ottoman themes.
Esotericism in Botswana
Authors: Podolecka Agnieszka , Nthoi Leslie 
Published: December 2021

Abstract
The article argues that “esotericism” can usefully be applied to a number of religious currents in Southern Africa. With a focus on Botswana, we survey a range of practices, from traditional “shamanic” healing to Pentecostal NRM s to New Age spiritualities and neoshamanism, some presented here for the first time. The term esotericism is useful for analysing the religious situation in Southern African contexts for three reasons. First, through a typological understanding of esotericism as initiation-based knowledge systems, we define one part of the landscape (usually termed “shamanism”) as constituting a form of “indigenous esotericism”. Second, through the European colonial expansion, this indigenous esotericism faced a violent rejection campaign that parallels the construction of “rejected knowledge” in Europe. While this forced many practices underground, they have resurfaced within Southern African Christianity. Third, “western” esoteric currents have recently been imported to Southern Africa and enter into dialogues with the “indigenous” forms.
Intertextual Agōnes in Archaic Greek Epic: Penelope vs. the Catalogue of Women
Authors: Nelson Thomas J. 
Published: December 2021

Abstract
Archaic Greek epic exhibits a pervasive eristic intertextuality, repeatedly positioning its heroes and itself against pre-existing traditions. In this article, I focus on a specific case study from the Odyssey: Homer’s agonistic relationship with the Catalogue of Women tradition. Hesiodic-style catalogue poetry has long been recognized as an important intertext for the Nekyia of Odyssey 11, but here I explore a more sustained dialogue across the whole poem. Through an ongoing agōn that sets Odysseus’s wife against catalogic women, Homer establishes the pre-eminence of his heroine and—by extension—the supremacy of his own poem.
Distinct Off-Equatorial Zonal Wind Stress and Oceanic Responses for EP- and CP-Type ENSO Events
Authors: McGregor Shayne , Dommenget Dietmar , Neske Sonja 
Published: December 2021

Abstract
This study utilizes observations and a series of idealized experiments to explore whether eastern Pacific (EP)- and central Pacific (CP)-type El Niño–Southern Oscillation (ENSO) events produce surface wind stress responses with distinct spatial structures. We find that the meridionally broader sea surface temperatures (SSTs) during CP events lead to zonal wind stresses that are also meridionally broader than those found during EP-type events, leading to differences in the near-equatorial wind stress curl. These wind spatial structure differences create differences in the associated pre- and post-ENSO event WWV response. For instance, the meridionally narrow winds found during EP events have (i) weaker wind stresses along 5°N and 5°S, leading to weaker Ekman-induced pre-event WWV changes; and (ii) stronger near-equatorial wind stress curls that lead to a much larger post-ENSO event WWV changes than during CP events. The latter suggests that, in the framework of the recharge oscillator model, the EP events have stronger coupling between sea surface temperatures (SST) and thermocline (WWV), supporting more clearly the phase transition of ENSO events, and therefore, the oscillating nature of ENSO than CP events. The results suggest that the spatial structure of the SST pattern and the related differences in the wind stress curl, are required along with equatorial wind stress to accurately model the WWV changes during EP- and CP-type ENSO events.
Outcome Disparities and Resource Utilization Among Limited English Proficient Patients After Tonsillectomy
Authors: Plocienniczak Michal , Rubin Batsheva R. , Kolli Alekha , Levi Jessica , Tracy Lauren 
Published: December 2021

Objective: There is evidence to suggest adverse outcomes on patients’ medical and surgical care when there is language discordance in patient-physician relationships. No studies have evaluated the impact of limited English proficiency (LEP) on complications after common surgical procedures in otolaryngology. Furthermore, no studies have evaluated how patients with LEP utilize remote resources to connect with otolaryngology providers to better triage such complications. The purpose was to evaluate the incidence of post-tonsillectomy hemorrhage (PTH) comparing patients with LEP to those with English proficiency (EP). Patients with PTH were retrospectively evaluated to identify preceding telephone encounters, a marker of resource utilization. Methods: Demographics, English proficiency, and PTH management (surgical vs non-surgical) were evaluated in addition to PTH-associated triage telephone encounters with otolaryngology providers. Results: Of 2466 tonsillectomies, there were 141 episodes of reported hemorrhage (50 LEP vs 91 EP) in the 5 years studied. Rates were not significantly different between LEP and EP patients (4.9% vs 6.3%, P = .127). There was no statistically significant difference in rate of preceding telephone encounters between LEP and EP patients (24% vs 40%, P = .062). Of patients presenting directly to the Emergency Department without a triage telephone encounter, there was no difference in operative versus non-operative management when comparing LEP versus EP patients. However, patients presenting directly to the Emergency Department were nearly twice as likely to undergo operative intervention compared to patients with preceding telephone encounters (RR = 1.79). Conclusion: Patients with limited English proficiency are not at increased risk for developing PTH. There is equitable access to remote otolaryngologic triage care, although overall the utilization rate of this resource was low for both cohorts.
Drug-Drug Interaction Between Orally Administered Hydrocodone-Acetaminophen and Inhalation of Cannabis Smoke: A Case Report
Authors: Bindler Ross Jason , Watson Christy J. W. , Lyons Abram J. , Skeiky Lillian , Lewis Jamie , McDonell Michael , Lazarus Philip , Wilson Marian 
Published: December 2021

Objective: To determine if a 2-day protocol measuring pharmacokinetic and pharmacodynamic characteristics can demonstrate drug-drug interactions when smoked cannabis is added to orally administered hydrocodone/acetaminophen combination products. Case Summary: A 51-year-old non-Hispanic white male with chronic pain diagnoses participated in a 2-day pilot protocol. The participant attended two 7-hour in-lab days where he received 10 blood draws each day and completed self-administered pain and anxiety surveys. For both days, the participant took his prescribed dose of hydrocodone/acetaminophen (1/2 tablet of 7.5 mg/325 mg combination product) with the addition of 1 smoked pre-rolled marijuana cigarette (labeled as 0.5 g; 22.17% Δ9-tetrahydrocannabinol; 0.12% cannabidiol) on Day 2. Blood specimens were analyzed using mass spectrometry to quantify the difference of plasma hydrocodone levels between Day 1 and Day 2. Results: Compared to Day 1, lower levels of pain and anxiety were reported during Day 2 with the addition of cannabis to oral hydrocodone/acetaminophen. Day 2 pharmacokinetic analysis also revealed more rapid absorption and overall lower levels of hydrocodone in plasma. Discussion: Lower hydrocodone plasma levels in Day 2 may indicate cannabis’s effect on metabolism and reduce the risk of opioid toxicity. The quicker absorption rate of hydrocodone could explain lower pain and anxiety scores reported on the second day. Conclusion and Relevance: A 2-day protocol was able to capture differences across time in pharmacokinetic and pharmacodynamic measurements. Larger studies can be designed to better characterize the potential drug-drug interaction of cannabis and opioids.
Book review: S. Levitsky & D. Ziblatt, How Democracies Die: What History Reveals About Our Future; D. Acemoglu & J.A. Robinson, Why Nations Fail: The Origins of Power, Prosperity and Poverty and D. Roy Chowdhury & J. Keane, To Kill a Democracy: India’s Passage to Despotism
Authors: Singh Mahendra Prasad 
Published: December 2021

S. Levitsky & D. Ziblatt, How Democracies Die: What History Reveals About Our Future. New York: Penguin Random House UK, 2018, £ 9.99. D. Acemoglu & J.A. Robinson, Why Nations Fail: The Origins of Power, Prosperity and Poverty. London: Crown, 2013 (South Asian Edition), ₹699. D. Roy Chowdhury & J. Keane, To Kill a Democracy: India’s Passage to Despotism. Oxford: Oxford University Press, 2021, £20.00; $25.95.
Psychometric Assessment of the Persian Version of Compassion Scale for Adolescents
Authors: Heidary Sara , Abdollahi Abbas , Jarrahi Elaheh , Ahmed Alim Al Ayub 
Published: December 2021

The compassion scale for adolescents is a 20-item self-report measure consisting of three dimensions, namely, compassion toward other people, compassion toward oneself, and compassion toward other living things. This scale evaluates compassion in adolescents aged between 12 and 18 years old. The purpose of the current study is to assess the psychometric properties of the compassion scale among Iranian adolescents in junior high school and senior high school students. The number of students who voluntarily took part in this research was 302. The relationships between the compassion scale, mindfulness, emotion regulation, and well-being were explored to assess the convergent validity. Furthermore, the relationship between the compassion scale and anxiety was investigated to assess the divergent validity. The results of confirmatory factor analysis supported the three factors of the compassion scale among Iranian junior and senior high school students same as the original version. The results show that the compassion scale appears to be a reliable and valid measure for Iranian adolescents.
Relying on the engagement of others: A review of the governance choices facing social media platform start-ups
Authors: Reuber A Rebecca , Fischer Eileen 
Published: December 2021

We are grateful to Professors Rebecca Reuber and Eileen Fischer for contributing our 2022 annual review article. This insightful review explores an issue of great contemporary importance regarding the relationship between entrepreneurial activities and social media platforms. Whilst there is much popular and media commentary regarding the opportunities such platforms offer for entrepreneurship, we lack informed, academic reflection upon the role and influence of such platforms for both good and ill. Hence, this review article is timely in identifying current practices and raising important issues for future research. Our thanks to the authors for their valuable contribution to the ISBJ. Entrepreneurs create digital platforms which, in turn, facilitate entrepreneurial behaviours of others, the platform users. An important start-up activity is developing the mechanisms to govern user participation. While prior literature has provided insights on the governance of innovation platforms and exchange platforms, it has shed little light on the governance of social media platforms. In this review, we synthesize the emerging literature on diverse social media platforms, focussing on four types of governance mechanisms: those that regulate user behaviour, those related to user identification and stature, those that structure relationships among users and those that direct user attention. We highlight the implications of this body of literature for entrepreneurship scholars.
Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray
Authors: Batistela Matheus F , Vilela-Costa Heloísa H , Frias Alana T , Hernandes Paloma M , Lovick Thelma A , Zangrossi Helio 
Published: December 2021

Background: Acute hypoxia, which is panicogenic in humans, also evokes panic-like behavior in male rats. Panic disorder is more common in women and susceptibility increases during the premenstrual phase of the cycle. Aims: We here investigated for the first time the impact of hypoxia on the expression of panic-like escape behavior by female rats and its relationship with the estrous cycle. We also evaluated functional activation of the midbrain panic circuitry in response to this panicogenic stimulus and whether short-term, low-dose fluoxetine treatment inhibits the hyper-responsiveness of females in late diestrus. Methods: Male and female Sprague Dawley rats were exposed to 7% O2. Females in late diestrus were also tested after short-term treatment with fluoxetine (1.75 or 10 mg/kg, i.p.). Brains were harvested and processed for c-Fos and tryptophan hydroxylase immunoreactivity in the periaqueductal gray matter (PAG) and dorsal raphe nucleus (DR). Results: Acute hypoxia evoked escape in both sexes. Overall, females were more responsive than males and this is clearer in late diestrus phase. In both sexes, hypoxia induced functional activation (c-Fos expression) in non-serotonergic cells in the lateral wings of the DR and dorsomedial PAG, which was greater in late diestrus than proestrus (lowest behavioral response to hypoxia). Increased responding in late diestrus (behavioral and cellular levels) was prevented by 1.75, but not 10 mg/kg fluoxetine. Discussion: The response of female rats to acute hypoxia models panic behavior in women. Low-dose fluoxetine administered in the premenstrual phase deserves further attention for management of panic disorders in women.
Reproductive intentions among HIV-negative gay and bisexual men initiating pre-exposure prophylaxis in the Sustainable Health Center Implementation pre-exposure prophylaxis pilot study, 2014–2016
Authors: Jones Jamal T , Coleman Megan , Hoover Karen W , Sarkodie Eleanor , Smith Dawn K 
Published: December 2021

Introduction We assessed reproductive intentions and associated characteristics among men enrolled in the Sustainable Health Center Implementation pre-exposure prophylaxis (PrEP) Pilot (SHIPP) Study. Methods We analyzed baseline data from 1275 men who self-identified as gay or bisexual and participated in the SHIPP study. SHIPP was a cohort study of PrEP implementation in five community health centers in Chicago, Jackson, Philadelphia, and Washington, D.C. conducted from 2014 to 2016. Participants completed audio computer-assisted self-interviews querying intentions to have a child in the future. We estimated the association between participants’ reproductive intentions and their characteristics using Poisson regression models. Results Approximately 47% of participants indicated their intentions to have a child. Black/non-Hispanic (aPR = 1.40; 95% CI: 1.10–1.78) and other/non-Hispanic participants (aPR = 1.40; 95% CI: 1.01–1.93) were more likely to report intentions to have a child than white/non-Hispanic participants. Participants were less likely to report intentions to have children as age increased (18–29 years, reference group; 30–39 years, aPR = 0.80, 95% CI: 0.64–0.99; 40–49 years, aPR = 0.49, 95% CI: 0.33–0.72; 50+ years, aPR = 0.07, 95% CI: 0.02–0.21). Conclusions Clinicians offering PrEP to black and other/non-Hispanic gay and bisexual men should assess their reproductive intentions as family-planning counseling may be an opportunity to introduce PrEP to HIV-negative gay and bisexual men.
Impact of poetry-based ethics education on the moral sensitivity of nurses: A semi-experimental study
Authors: Rashidi Kobra , Ashktorab Tahereh , Birjandi Mehdi 
Published: December 2021

Background: The nurses’ moral sensitivity is the first step to make right decisions in difficult moral situations. Therefore, its education and promotion is highly important. Research objectives: The aim of this study was to examine the impact of poetry-based ethics education on the nurses’ moral sensitivity. Research design and methods: This was a semi-experimental study. The sample consisted of 108 nurses who were selected by convenience sampling method and randomly assigned to three groups: intervention with poetry (G1), who read a booklet about values and principles of professional ethics as well as poems related to these subjects for 1 month; intervention without poetry (G2), who only read the booklet without any poetry; and control group (G3), who did not receive any intervention. Data were collected by Moral Sensitivity Questionnaire that was completed by the participants prior to the intervention (T1), 1-month post-intervention (T2), and 2-month post-intervention (T3). Data were analyzed by SPSS 16 software. Ethical considerations: This study was conducted in accord with the principles of research ethics and regulations relating to informed consent. Findings: Changes in the mean score of total moral sensitivity were significantly higher in G1 than in G2, which was in turn significantly higher than in G3. This increase was significant from T1 to T2 and T2 to T3 (P < 0.001). In all subscales, there was a significant difference between the mean changes in the three groups, so that in these subscales, the mean changes in G1 were significantly higher than those in other groups. Discussion: In line with previous studies, our results showed the effectiveness of poetry-based education on the transfer of educational concepts and increase moral sensitivity scores with greater lasting effect. Conclusion: The use of interdisciplinary subjects such as poetry, due to its entertaining, fun, and lasting effect on minds; level of awareness; and actions of nurses, can help raise nursing moral sensitivity.