bluuebunny/crossref_metadata_2025_split huggingface dataset:
ĐA HÌNH MICROSATELLITE LIÊN KẾT VỚI GEN HEPCIDIN/HAMP TIỀM NĂNG TRONG CHỌN GIỐNG CÁ RÔ PHI VẰN KHÁNG BỆNH DO Streptococcus iniae
Authors: Nhật Phạm Hồng , Ho Chia -Hui , Tseng Po -Chun , Gong Hong -Yi 
Published: November 2021

Bệnh xuất huyết do vi khuẩn Streptococcus sp là mầm bệnh truyền nhiễm chính gây thiệt hại đáng kể đến sản lượng cá rô phi toàn cầu. Hepcidin/HAMP ở cá đã được báo cáo có liên quan đến miễn dịch bẩm sinh chống lại các mầm bệnh vi khuẩn. Trong nghiên cứu này, chúng tôi tiến hành phân tích mối quan hệ giữa tính đa hình microsatellites/SSRs liên kết với gen hepcidin/HAMP và khả năng kháng bệnh do Streptococcus iniae trên cá rô phi vằn dòng NT1 (Đài Loan). 17 chỉ thị SSRs và cặp mồi đặc hiệu đã được thiết kế dựa trên WebSat. Kết quả đánh giá trên 95 cá thể cho thấy 9/17 chỉ thị SSRs có tính đa hình cao và tuân theo định luật Hardy-Weinberg. Các chỉ thị này sẽ được sử dụng để đánh giá khả năng kháng vi khuẩn S. iniae. 29 cá rô phi NT1 thế hệ thứ nhất (khối lượng 23,59 ± 5,388 g/con) đã được cảm nhiễm với vi khuẩn S. iniae 89353 bằng phương pháp tiêm, với liều tiêm LD50 là 1,3x105 cfu/mL. Kết quả phân tích cho thấy, có sự sai khác có ý nghĩa thống kê về kiểu gen và tần số alen giữa nhóm sống và nhóm chết sau cảm nhiễm vi khuẩn ở 3 chỉ thị SSRs (SSR7, SSR9 và SSR16) (p<0,05). Đây là marker có tiềm năng cho chọn giống cá rô phi Đài Loan kháng bệnh do S. iniae.
ABSTRACT
Streptococcus has been recognized as a major infectious disease-causing significant economic loss in tilapia aquaculture in many countries. The hepatic antimicrobial peptide hepcidin/HAMP was reported to be associated with innate immunity which defends against various bacterial pathogens and viruses. In this study, we analyzed the corelation between the microsatellites/SSRs polymorphism in the hepcidin/HAMP genes and the resistance to Streptococcus iniae in the NT1strain (tilapia strain in Taiwan). Seventeen of hepcidin/HAMP-related SSRs and 17 SSR-specific PCR primer were designed using WebSat. The result showed that 9/17 hepcidin/HAMP-related SSRs were polymorphic markers and there is significant deviation from Hardy-Weinberg Equilibrium (HWE) (p<0,05). These SSRs were examined for disease resistance to S. iniae. Twenty-nine the First generation (G1) tilapia of NT1 strain (average weight of 23,59 ± 5,388g/fish) were challenged with virulent S. iniae 89353 through intraperioneal injection at dose of LD50 (1,3x105 cfu/ml). In this study, the genotype and the allele frequency in three SSRs (SSR7, SSR9 và SSR16) were significantly different between two groups (death fish with infected signals of S. iniae and alive fish infected with S. iniae) (p<0,05). Three SSRs (SSR7, SSR9 và SSR16) are considered as potential molecular markers for selective breeding of Taiwanese tilapia which resists to S. iniae.
Translation and validation study of Quality of Life Questionnaire for Physiological Pregnancy at Sandeman Provincial Hospital, Quetta, Pakistan
Authors: Rabia Ishaq  , Aiesha Ishaque  , Qaiser Iqbal  , Faisal Shahzad  , Nafees Ahmed  , Fahad Saleem  
Published: November 2021

Objective
To examine the psychometric properties of the Urdu version of the Quality of Life Questionnaire for Physiological Pregnancy (QOL-GRAV).
Methods
This cross-sectional study was conducted at the Obstetrics, Gynecology department of Sandeman Provincial Hospital, Quetta. The QOL-GRAV was translated into Urdu by using a forward-backward procedure. The test-retest reliability was assessed through Cronbach’s alpha reliability analysis. The validity of the translated questionnaire was constructed by using Exploratory Factor Analysis (EFA) through principal axis factoring extraction and Oblique rotation with Kaiser Normalization. SPSS v 20.0 was used for data analysis with p<0.05 as significant.
Results
The Urdu version of the questionnaire (QOL-GRAV-U) exhibited acceptable alpha values of 0.780 (Test) and 0.812 (Retest) at two-time points with an overall value of 0.790 (field test). All items of the QOL-GRAV-U showed good stability with Intraclass Correlation Coefficient values of > 0.80. The Kaiser-Meyer-Olkin measure of sampling adequacy for the factor analysis was 0.812. Barlett’s Test of Sphericity was significant (Chi-square = 1032.43; p < 0.05) revealing relationships of the data and suitability of EFA. Three factors explaining the total variance of 65% were extracted whereby loading values for all nine constructs were acceptable (> 0.40).
Conclusion
The results of this study conclude that the translated version of QOL-GRAV-U is a valid and reliable instrument for the assessment of QoL for pregnant women in regions where Urdu is a prime language of communication.
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Endoxifen, A new hope for Bipolar Disorder
Authors: Amin Muneeba , Shafique Alviya , Hafiz Muhammad Yusuf 
Published: November 2021

Bipolar Disorder (BD), originally called manic depressive illness, is one of the most challenging and disabling psychiatric disorders to manage with an estimated life time prevalence of 1.02%. (1) One of the challenges is limitations in our understanding of the pathophysiology of the disorder which ultimately will lead to better treatment options. Despite available treatment options, literature reports breakthrough episodes in treated groups ranging from 40% to 60%. (2) This makes it even more crucial to gain more insight into the pathophysiology. Advances in molecular neuropsychiatry have reported that bipolar disorder is associated with overactive protein C kinase intracellular signaling. (3) Reportedly, lithium and valproate are protein C kinase inhibitors. Research has shown promise in effectiveness of Endoxifen. A multicenter, double-blind, active-controlled study was conducted using Endoxifen compared with Divalproex, the current standard treatment, in patients with BD. This new protein kinase C inhibitor has shown effectiveness in the treatment of acute mania and mixed mania. (4) One of the many advantages include similar efficacy as Divalproax without inducing thrombocytopenia and reportedly no need for drug monitoring due to wide therapeutic index is one of the reasons which results in decreased compliance. Additionally, it crosses the blood-brain barrier independent of CYP-2D6 metabolism. (4) With regards to disadvantages, cost effectiveness is a major hurdle. These new insights into pathophysiology and treatment options are crucial as till date BD remains one the most disabling mental health disorder affecting every aspect of life; individual, social, economic, global. BD is the fifth leading cause among psychiatric disorders of lost years of work. (5) It is therefore imperative that a new treatment is established and further research is warranted in regards to Endoxifen for better understanding to develop safe treatment, not only for management but possible cure.
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Predicting drought using Bayesian structural time series model
Authors: Wang Sophia , Lee Connor , Pang XL 
Published: November 2021

The western U.S. has been experiencing a mega-scale drought since 2000. By killing trees and drying out forests, the drought triggers widespread wildfire activities. In the 2020 California fire season alone, more than 10.3 million acres of land were burned and over 10000 structures were damaged. The estimated cost is over $12 billion. Drought also devastates agriculture and drains the social and emotional well-being of impacted communities.
This work aims at predicting the occurrence and severity of drought, and thus helping mitigate drought related adversaries. A machine learning based framework was developed, including time series data collection, model training, forecast and visualization. The data source is from the National Drought Monitor center with FIPS (Federal Information Processing Standards) geographic identification codes. For model training and forecasting, a Bayesian structural time series (BSTS) based statistical model was employed for a time-series forecasting of drought spatially and temporally. In the model, a time-series component captures the general trend and seasonal patterns in the data; a regression component captures the impact of the drought in measurements such as severity of drought, temperature, etc. The statistical measure, Mean Absolute Percentage Error, was used as the model accuracy metric. The last 10 years of drought data up to 2020-09-01 was used for model training and validation. Back-testing was implemented to validate the model . Afterwards, the drought forecast was generated for the upcoming 3 weeks of the United States based on the unit of county level. 2-D heat maps were also integrated for visual reference.
The Effect of Sports Experience and Competitive Orientation on Entrepreneurial Priorities, Attitudes, and Decision Making.
Authors: Arikatla Vedha , Gregorich Genevieve 
Published: November 2021

This paper poses a few questions about the link between athletic experience and entrepreneurial behavior. Does athletic experience affect entrepreneurial attitudes, decisions, and, therefore, outcomes? If so, is it specifically their competitive orientation that drives these differences? This paper uses survey data to observe differences in attitudes, decisions, leadership, and strategy between athletes and non-athletes. This paper also implements an experiment, which randomly assigns half of the participants to be primed by recalling a competitive situation to test whether differences in behavior between athletes and non-athletes can be attributed to a competitive mindset. The survey undertaken for this purpose received 100 responses.
In this research, I also specifically examine the role that a competitive mindset, which is frequently developed through sports, plays in entrepreneurial attitudes, priorities, and strategies. This paper tests if athletes and non-athletes make different decisions in the face of entrepreneurial challenges. It also examines whether any of those differences can be attributed to the competitive orientation of people with athletic experience.
A expressão de resultado do conector Daí Que: mudança linguística em perspectiva funcional centrada no uso
Authors: Arena Ana Beatriz , Teixeira Ana Cláudia Machado 
Published: November 2021

Neste artigo, voltamo-nos para a análise da mudança linguística de daí que no português, tomando-o como um novo signo linguístico, ou seja, como um pareamento específico de sentido e forma, uma microconstrução. Integrada simbolicamente em suas subpartes, essa microconstrução passa a constituir um novo elemento da classe dos conectores da gramática do português. O estudo desse conector integra uma pesquisa maior, em andamento, que investiga a rede construcional ResultadoConect, analisando diferentes formas de conexão, nos níveis intra, inter e supraoracional por meio de distintos conectores que articulam a expressão de resultado no português. Utilizamos os pressupostos teóricos da Linguística Funcional Centrada no Uso, incorporando o levantamento das frequências type e token (BYBEE, 2003) como auxiliares no reconhecimento da produtividade do daí que e dos padrões de uso determinantes na sua fixação como conector lógico-argumentativo na expressão de resultado. Compõem o corpus textos escritos dos períodos arcaico, moderno e contemporâneo da língua portuguesa.
Relevansi Teori Keraguan Descartes bagi Pendidikan Agama Kristen yang Dialogis
Authors: Ayu Ni Gusti , Lado Addy Purnomo , Sinurat Evani April 
Published: November 2021

Abstract: The fundamental understanding of religion positions its adherents in a closed attitude to dialogue. Descartes opposed the fundamental understanding of a truth, because for him every truth could be doubted. Departing from Descartes' thought, many people use Descartes' method of doubt as a basis for arguments against religious fundamentalism. By using the library method, the author utilizes the relevant literature to process various information that can be used as study material. In relation to Christian Religious Education (PAK), doubt contributes to encouraging students to think critically and to realize a dialogical learning process. Thus, the act of doubting does not need to be feared or avoided, but rather as a very human thought process to find the ultimate truth.Abstrak: Pemahaman agama yang fundamental memposisikan penganutnya pada sikap tertutup akan dialog. Descartes menentang pemahaman fundamental tentang suatu kebenaran, karena baginya setiap kebenaran dapat diragukan. Berangkat dari pemikiran Descartes, banyak orang menggunakan metode keraguan Descartes sebagai dasar argumen menentang fundamentalisme agama. Dengan menggunakan metode kepustakaan, penulis memanfaatkan literatur yang relevan untuk mengolah berbagai informasi yang dapat digunakan sebagai bahan kajian. Dalam kaitannya dengan Pendidikan Agama Kristen (PAK), keraguan memberikan sumbangsih untuk mendorong siswa berpikir kritis dan mewujudkan proses belajar yang dialogis. Dengan demikian, tindakan meragu tidak perlu ditakuti atau dihindari, melainkan sebagai sebuah proses berpikir yang sangat manusiawi untuk menemukan kebenaran yang hakiki.
PENINGKATAN HASIL BELAJAR IPA SISWA KELAS VIII SMP PARULIAN 1 MEDAN MENGGUNAKAN MODEL PEMBELAJARAN INKUIRI BERBANTUAN ANIMASI
Authors: Surbakti Mariana , Sitorus Arjo Saputra , Sitorus Parlindungan 
Published: November 2021

This research is motivated by the low science scores of students at the school, so researchers want to conduct research to find out if there is an increase in student learning outcomes in science when using the animation-assisted inquiry learning model. This type of research is quasi-experimental, the research design used is Two Group Pre test-Post test Design, eighth and the research population is all grade students of SMP Swasta Parulian 1 Medan. The instrument used in the learning outcomes test was 20 multiple choice questions which were validated by 2 science teachers in junior high school. The research result shows the score average pre test of 37.80 in 40.00 in the experimental class and control class and score post test of 82.00 in 71.00 in the experimental class and control class. Each sample group has normal data and has been tested using the Lilliefors test using SPSS, with the calculation of the results pre test obtained that L significance > 0.05, namely (0.114 > 0.05) for the experimental class and (0.148 > 0.05) for the experimental class. control, and the results post test obtained that L significance > 0.05, namely (0.066 > 0.05) for the experimental class and (0.071 > 0.05) for the control class. Furthermore, the data for both samples have homogeneous variances and have been tested using the SPSS F test, with the calculation of the results pre test obtained that F significance > 0.05 (0.728 > 0.05), and the results post test obtained that F significance 0.05 ( 0.050 ≥ 0.05). The research hypothesis test was carried out using the t-test (one-sided test). From the calculation results, it is obtained that the t significance < 0.05 is (0.000 < 0.05). then the result of hypothesis Ha is accepted. Based on the results of the overall data analysis, the t significance of < t is (0.000 < 0.05) and simple regression analysis Y = a + bx is Y = 38.347 + 0.573X. Inquiry learning model assisted by animation media can improve student learning outcomes with a large effect of increasing learning outcomes 15.5% which has a correlation coefficient of r = 0.491 (medium positive correlation). In conclusion, science learning outcomes using an inquiry learning model assisted by animation media can increase student learning outcomes by 15.5%.
КУӘ ҚЫЛМЫСТЫҚ ПРОЦЕСКЕ ҚАТЫСУЫ ТУРАЛЫ
Authors: Кадацкий Сергей , Рахимов Серик 
Published: November 2021

В статье рассматриваются отдельные вопросы, связанные с участием понятых при проведении следственных действий, их процессуальным статусом и ролью в обеспечении достоверности доказательств, получаемых при производстве по уголовному делу. Озвучивается негативная реакция лиц, приглашаемых в качестве понятых. Исследуются проблемы обеспечения выполнения требования закона относительно их незаинтересованности в деле и установления независимости от органов уголовного преследования. Отмечается отсутствие у органа расследования возможности достоверно убедиться в том, что приглашенные граждане действительно не заинтересованы в исходе дела. Предлагается привлекать понятых по усмотрению лица, ведущего уголовный процесс. Такое усмотрение может возникнуть при наличии предположения об отсутствии объективной возможности восприятия информации при производстве следственных действий.
Мақалада тергеу әрекеттері кезінде куәрдің қатысуымен, олардың іс жүргізу мәртебесімен және қылмыстық іс жүргізу барысында алынған дәлелдемелердің сенімділігін қамтамасыз етудегі рөлімен байланысты кейбір мәселелер талқыланады. Куә ретінде шақырылған адамдардың теріс реакциясы айтылды. Олардың іске қызығушылық танытпауы және қылмыстық қудалау органдарынан тәуелсіздігін белгілеу туралы заң талаптарының орындалуын қамтамасыз ету мәселелері зерттелуде. Сонымен бірге, тергеу органының шақырылған азаматтардың істің нәтижесіне шынымен де мүдделі емес екендігіне сенімді түрде көз жеткізуге мүмкіндігі жоқ екендігі атап өтіледі. Куәрді қылмыстық процесті жүргізетін адамның қалауы бойынша тарту ұсынылады. Тергеу әрекеттерін жасау кезінде ақпаратты қабылдаудың объективті мүмкіндігі жоқ деген болжам болса, мұндай дискреция туындауы мүмкін.
The article discusses certain issues related to the participation of attesting witnesses during investigative actions, their procedural status and their role in ensuring the reliability of evidence obtained in the course of criminal proceedings. The negative reaction of the persons invited as attesting witnesses is voiced. The problems of ensuring compliance with the requirements of the law regarding their disinterest in the case and establishing independence from the criminal prosecution authorities are investigated. It is noted that the investigating body cannot reliably verify that the invited citizens are not interested in the outcome of the case. It is proposed to involve attesting witnesses at the discretion of the person conducting the criminal proceedings. Such discretion may arise if there is an assumption about the absence of an objective possibility of perceiving information during the production of investigative actions.
Nghiên cứu các nhân tố ảnh hưởng đến sự hài lòng của sinh viên đối với hoạt động giảng dạy của giảng viên
Authors: Nguyễn Bích Như 
Published: November 2021

Bài viết báo cáo kết quả nghiên cứu sự hài lòng của sinh viên đối với hoạt động giảng dạy của giảng viên tại một trường cao đẳng sư phạm. Nghiên cứu đã phát hiện 6 nhân tố có ảnh hưởng cùng chiều với Sự hài lòng của sinh viên về hoạt động giảng dạy của giảng viên là (1) Phương tiện giảng dạy, (2) Nội dung giảng dạy, (3) Phương pháp giảng dạy, (4) Sự kết hợp giữa phương tiện, nội dung và phương pháp giảng dạy, (5) Sự nhiệt tình của giảng viên, (6) Sự quan tâm của giảng viên đến sinh viên. Trong đó, có ảnh hưởng lớn nhất là nhân tố Sự quan tâm của giảng viên đến sinh viên và ảnh hưởng ít nhất là nhân tố Nội dung giảng dạy.
Sleep state misperception: is there a CNS structural source?
Authors: Truzzi Giselle de Martin , Teixeira Igor de Lima , Prado Lucila Bizari Fernandes do , Prado Gilmar Fernandes do , Tufik Sergio , Coelho Fernando Morgadinho 
Published: November 2021

ABSTRACT
Introduction: We describe a case of sleep state misperception in a patient with a neurotoxoplasmosis lesion in the left nucleocapsular region.
Case report: A 40-year-old female patient presented relating sleeplessness over the past 2 years, concurrent with progressive headaches, dizziness and motor and sensory deficits in the right upper and lower limbs. She had a history of AIDS, on irregular antiretroviral therapy and neurotoxoplasmosis. A polysomnography confirmed the hypothesis of sleep state misperception, and magnetic resonance imaging revealed a residual lesion in the left nucleocapsular region.
Conclusion: Different models consider that the sleep state misperception could be correlated to structural abnormalities of the central nervous system. A recent study showed that the medial prefrontal cortex had a lower activation in patients with unrefreshing sleep due to chronic fatigue syndrome. This case report highlights the possibility of sleep state misperception having - at least partially - an anatomical substrate in the left nucleocapsular region.
Self-reported current sleep behaviors of adult athletes from different competitive levels and sports
Authors: Randell Rebecca K , Anderson Rosie , Carter James M , Rollo Ian 
Published: November 2021

ABSTRACT
Objectives: To quantify self-reported current sleep behaviors in a range of adult athletes. In addition, to determine any differences in sleep duration and sleep quality, depending on sport type and competitive level.
Material and Methods: In this cross-sectional study, 313 athletes (243 male, 70 female), competing in a variety of sports and competitive level, completed the Pittsburgh sleep quality index (PSQI) and a questionnaire which captured current sleep behaviors. Sleep quality was calculated using the global PSQI score (≥ 5 indicative of poor sleep quality).
Results: On average, athletes self-reported sleep duration was 7:34 ± 1:00 h:min. Overall, 19% of athletes achieved less than 7 h of sleep, 50% achieved less than 8 h. Global PSQI score was 5.0 ± 2.4, with poor sleep quality found in 55% of athletes. Sleep duration was significantly shorter in runners compared to basketball, soccer and rugby players (p < 0.05). Recreational athletes slept significantly less (7:08 ± 0:54 h:min) than competitive (7:32 ± 1:00 h:min), national (7:50 ± 1:00 h:min) and elite level athletes (7:49 ± 0:51 h:min). No differences in sleep quality were found between sport or competitive level.
Discussion: Half of the athletes failed to achieve 8 h of sleep per night and the majority reported compromised sleep quality. Sport type and competitive level may influence sleep duration; however, these factors do not seem to cause discrepancies in sleep quality. This study provides novel data into the sleep behaviors of adult athletes, and suggests strategies to improve sleep duration and quality may be warranted.
Assessment of sleep quality and its association with problematic internet use among university students: a cross-sectional investigation in Bangladesh
Authors: Islam Zohurul , Hsan Kamrul , Islam Saiful , Gozal David , Hossain Mahfuz 
Published: November 2021

ABSTRACT
Objectives: Problematic internet use (PIU) is a major behavioral problem that has been closely associated with poor sleep quality in many different countries, but is poorly studied in Bangladesh. This study was conducted to investigate the sleep quality and its association with PIU among university students in Bangladesh.
Material and Methods: A cross-sectional study was conducted between May 2019 and December 2019 among 400 students attending four public universities in Bangladesh. The Pittsburgh sleep quality index (PSQI) was used to determine sleep quality and Young’s internet addiction test (IAT) was used to describe the degree of PIU.
Results: A significant negative association emerged between good sleep quality and PIU (p<0.001). In the multivariate logistic regression, students having PIU were 0.28 folds less likely to have good sleep quality (AOR: 0.28, 95%CI=0.18-0.43, p<0.001) when compared to non-PIU students. In addition, significant associations between sleep quality and socio-demographic and lifestyle factors were identified.
Conclusion: Implementation of an effective awareness program and development of education strategies are required to reduce internet addictive behaviors and improve sleep quality among Bangladeshi university students.