bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRESCRIÇÕES DE MEDICAMENTOS SUJEITOS A CONTROLE ESPECIAL EM UM MUNICÍPIO DO SERIDÓ POTIGUAR, BRASIL
Authors: Soares da Nóbrega Silva Lucas , Ideão Leite da Rocha Maria Vitória , Mariz Batista Almária 
Published: July 2021

A prescrição de medicamentos constitui uma intervenção terapêutica e deve considerar aspectos técnico-legais e usuário-centrados para alcançar a efetividade da terapia e a segurança do paciente. Desta forma, foram avaliadas prescrições de medicamentos sujeitos a controle especial na atenção primáriado município de Caicó, RN, com base na legislação em vigor, por meio de um estudo transversal, descritivo-exploratório, quantitativo, baseado no receituário de controle especial elaborado por médicos durante o período de julho de 2018 a junho de 2019, arquivado na Central de Abastecimento Farmacêutico municipal. Também foi analisada a classificação farmacológica dos medicamentos prescritos, bem como sua conformidade com a Relação Municipal de Medicamentos Essenciais. Ao todo, foram avaliadas 1.682 prescrições. Houve predomínio de prescrições não conformes (99,77%), cujos itens duração do tratamento (97,1%), via de administração (89,3%) e nomenclatura do medicamento por princípio ativo (14,6%) foram os mais prevalentes quanto a não conformidades. Quanto às classes farmacológicas dos medicamentos prescritos, predominaram ansiolíticos benzodiazepínicos (30,97%). Todos os medicamentos prescritos estavam em conformidade com a lista de medicamentos essenciais municipal. Depreende-se a necessidade de reorientação da formação profissional médica, através de inserção e/ou maior ênfase a estratégias para elaboração de prescrições em observância a preceitos técnico-legais e usuário-centrados, além de educação e trabalho interprofissionais, a fim de contribuir para assistência usuário-centrada, melhoria de segurança do paciente, acesso e efetividade no contexto da assistência à saúde.
POTENCIAL ANTIBACTERIANO DO ÓLEO ESSENCIAL DE LIPPIA ALBA MILL. ASSOCIADO A LUZES DE LED
Authors: Santos Vitoria Ruana Sales , Sousa Júnior Dárcio Luiz de , Freitas Jailson de Castro , Aquino Pedro Everson Alexandre de , Silva Leandro Maria Karollyna do Nascimento , Leandro Lívia Maria Garcia , Macedo da Silva Rakel Olinda 
Published: July 2021

Lippia alba Mill., também conhecida como erva cidreira, é um subarbusto aromático que ocorre em todo território brasileiro. Seu óleo essencial possui muitas atividades, mas ainda são escassos estudos do seu uso associado à fototerapia. O objetivo desse estudo foi avaliar a atividade antibacteriana do óleo essencial de Lippia alba (OEL) associado a luzes de LED (Light Emitting Diode) azul, vermelha e amarela contra cepas de Staphylococcus aureus e Escherichia coli. O óleo foi extraído pelo método de hidrodestilação. A atividade antibacteriana e moduladora foi avaliada pelo método de contato gasoso utilizando o óleo, luzes de LED e antibióticos, os quais foram realizados em triplicata. O OEL possui um potencial antibacteriano frente todas as cepas testadas tendo um resultado mais expressivo na cepa multirresistente de E. coli quando associado a luzes de LED. Na modulação da resistência bacteriana, tanto nas combinações do óleo + antibiótico + luzes de LED como óleo + antibióticos, houve sinergismo frente às linhagens multirresistentes de ambas as cepas testadas. Os resultados obtidos no presente estudo mostraram que o óleo essencial de Lippia alba associado às luzes de LED possui efeito antibacteriano e modulador pelo método de contato gasoso. Estes dados obtidos poderão colaborar com pesquisas futuras que visem o desenvolvimento de novas estratégias terapêuticas no combate de microrganismos resistentes.
The Measurement of Unfrozen Water Content and SFCC of a Coarse-Grained Volcanic Soil
Authors: Ren Junping , Zhang Shoulong , Wang Chong , Ishikawa Tatsuya , Vanapalli Sai K. 
Published: July 2021

Abstract
In frozen soils, a portion of pore water remains unfrozen due to the effects of capillarity, adsorption, and possibly solute. The variation of the amount of unfrozen water and ice in a frozen soil, which is primarily influenced by subzero temperature, has great impacts on the physical and mechanical behavior of the soil and is critical for broad applications ranging from engineering to climate change. In the present study, the various methods that have been used for determining unfrozen water (and ice) content are comprehensively reviewed. Their principles, assumptions, advantages, and limitations are discussed. It is noted that there is yet no perfect way to accurately quantify unfrozen water content in frozen soils. In addition, the soil-freezing characteristic curve (SFCC) of a typical volcanic soil sampled in the Hokkaido prefecture of Japan is investigated. The unfrozen water content of the prepared soil specimens was measured using a cheap moisture sensor, which is based on the frequency domain reflectometry technique. The temperature of the specimens was determined by a rugged temperature sensor. Different numbers of freeze-thaw (F-T) cycles and different freezing/thawing methods (i.e., one- and three-dimensional) were considered, and their effects on the SFCC were investigated. The experimental results suggest that neither the F-T cycles nor the freezing/thawing methods had significant influence on the measured SFCC. The presented comprehensive review and experimental investigations are of importance for both the scientific and engineering communities.
Debevoise’s Holloway Project and “Second Looks”
Authors: Gleeson John 
Published: July 2021

The president’s power to grant clemency is but one feature of a sentence-correction ecosystem. But the abolition of federal parole in the 1980s left the clemency power as the only way to correct lawfully imposed sentences for the simple reason that they are too damn long. This article is about another way to correct sentences for that simple reason, one that has been right there all along but was moribund for decades, and about a 2018 statute and a Debevoise & Plimpton pro bono project that breathed life into it. And it is a critical Article III complement to the Article II clemency power.
For the past five years, the Holloway Project at Debevoise has advocated for federal prisoners, overwhelmingly men of color, who were given bone-crushing sentences pursuant to the cruelest mandatory sentencing law the federal system had to offer. The typical Holloway Project client is a middle-aged man who was sentenced decades ago for robbery sprees in which a firearm was used but no one was hurt and little was stolen. In almost all of their cases, the indefensible sentences—often as not the equivalent of life without parole—had nothing to do with their culpability and everything to do with their refusals to cooperate and/or plead guilty.
This article describes the Holloway Project and how it has used what has become known colloquially as the “compassionate release” statute, 18 U.S.C. § 3582(c)(1)(A), and 2018’s First Step Act to persuade federal judges to undertake holistic, compassionate reevaluations of the men these incarcerated individuals have become after all their years in prison, and inject some humanity and justice into a sentencing regime that is still in desperate need of both.
Oncogenic osteomalacia secondary to glomus tumor
Authors: Raj Rishi , Hasanzadeh Samaneh , Dashtizadeh Mitra , Kalantarhormozi Mohammadreza , Vahdat Katayoun , Dabbaghmanesh Mohammad Hossein , Nabipour Iraj , Ravanbod Mohammdreza , Assadi Majid , Hashemi Basir , Asadipooya Kamyar 
Published: July 2021

Summary
Oncogenic osteomalacia secondary to glomus tumor is extremely rare. Localization of causative tumors is critical as surgical resection can lead to a complete biochemical and clinical cure. We present a case of oncogenic osteomalacia treated with resection of glomus tumor. A 39-year-old woman with a history of chronic sinusitis presented with chronic body ache and muscle weakness. Biochemical evaluation revealed elevated alkaline phosphatase hypophosphatemia, increased urinary phosphate excretion, low calcitriol, and FGF23 was unsuppressed suggestive of oncogenic osteomalacia. Diagnostic studies showed increase uptake in multiple bones. Localization with MRI of paranasal sinuses revealed a sinonasal mass with concurrent uptake in the same area on the octreotide scan. Surgical resection of the sinonasal mass was consistent with the glomus tumor. The patient improved both clinically and biochemically postoperatively. Along with the case of oncogenic osteomalacia secondary to a glomus tumor, we have also discussed in detail the recent development in the diagnosis and management of oncogenic osteomalacia.

Learning points

Tumor-induced osteomalacia is a rare cause of osteomalacia caused by the secretion of FGF23 from mesenchymal tumors.

Mesenchymal tumors causing TIO are often difficult to localize and treat.

Resection of the tumor can result in complete resolution of biochemical and clinical manifestations in a very short span of time.

Glomus tumor can lead to tumor induced osteomalacia and should be surgically treated.
Effect of once weekly oral levothyroxine therapy
Authors: Toro-Diez Andrea del , Solá-Sánchez Ernesto , Mangual-García Michelle 
Published: July 2021

Summary
Primary hypothyroidism is one of the most common endocrine disorders with widely available treatment. A minority of patients remain with uncontrolled hypothyroidism despite therapy. The objective of this case series was to demonstrate that medication non-adherence, rather than malabsorption, should be sought as the most common cause of unsuppressed TSH levels in patients receiving treatment for this condition. Non-adherence is often considered as a diagnosis of exclusion. Nonetheless, a diagnosis of malabsorption requires a more extensive workup, including imaging and invasive procedures, which increase healthcare costs and burden to the patient. The findings of this study allow for a cost-effective approach to uncontrolled hypothyroidism.

Learning points

Medication non-adherence is a common cause of insuppressible TSH levels.

Once weekly levothyroxine is an alternative approach to non-compliant patients.

Assessing compliance is more cost-effective and less burdensome than testing for malabsorption.
Fonética y fonología de las consonantes oclusivas del guaymí hablado en Costa Rica
Authors: Vega Chavarría Melany 
Published: July 2021

The present work consists of an analysis of the phonetic and phonological properties of the sequences /t-k/ and /b-d-ɡ/ from the Guaymi spoken in La Casona, Puntarenas, Costa Rica. The corpus was analyzed with Speech Analyzer and the Lisker and Abramson (1964) method was applied in order to obtain the values of the V.O.T. The results suggest that the sequence /t-k/ does not present systematic allophonic variations, while /b-d-g/ alternates with stop, fricative, and approximant allophones; neutralization among stop phonemes is not frequent. Lastly, the V.O.T. contributes to the differentiation between voiceless and voiced stops.
Vignettes Identify Variation in Antibiotic Use for Suspected Early Onset Sepsis
Authors: Payton Kurlen S. E. , Wirtschafter David , Bennett Mihoko V. , Benitz William E. , Lee Henry C. , Kristensen-Cabrera Alexandria , Nisbet Courtney C. , Gould Jeffrey , Parker Colin , Sharek Paul J. 
Published: July 2021

BACKGROUND AND OBJECTIVES
There is widespread unwarranted antibiotic use and large individual provider variation in antibiotic use in NICUs. Vignette-based research methodology offers a unique method of studying variation in individual provider decisions. The objective with this study was to use a vignette-based survey to identify specific areas of provider antibiotic use variation in newborns being evaluated for early onset sepsis.

METHODS
This study was undertaken as part of a statewide multicenter neonatal antibiotic stewardship quality improvement project led by a perinatal quality improvement collaborative. A web-based vignette survey was administered to identify variation in decisions to start and discontinue antibiotics in cases of early onset sepsis.

RESULTS
The largest variation was noted in 3 of the 6 vignette cases. These cases highlighted variation in (1) decisions to start antibiotics in a case describing a well-appearing newborn with risk factors and an elevated C-reactive protein, (2) decisions to start antibiotics in the case of a newborn with risk factors plus mild respiratory signs at birth, and (3) decisions to stop antibiotics in the case of the newborn with a history of sepsis risk factors and mild clinical respiratory signs that resolved after 72 hours.

CONCLUSIONS
Clinical vignette assessment identified specific areas of variation in individual provider antibiotic use decisions in cases of suspected early onset sepsis. Vignettes are a valuable method of describing individual provider variation and highlighting antibiotic stewardship improvement opportunities in NICUs.
Psychiatric Phenotypes of Pediatric Patients With Seropositive Autoimmune Encephalitis
Authors: Adams Ashley V. , Van Mater Heather , Gallentine William , Mooneyham GenaLynne C. 
Published: July 2021

OBJECTIVES
Patients with autoimmune encephalitis (AE) often present with symptoms that are broadly characterized as psychiatric or behavioral, yet little attention is given to the precise symptomatology observed. We sought to more fully define the psychiatric symptoms observed in patients with anti–N-methyl-D-aspartate receptor (NMDAR), anti–glutamic-acid-decarboxylase 65 (GAD65), and anti–voltage-gated-potassium-channel complex (VGKC) antibody-mediated AE using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition nomenclature.

METHODS
We present a case series (n = 25) using a retrospective chart review of 225 patients evaluated for AE in a tertiary care academic medical center between 2014 and 2018. The included patients were ≤18 years old with anti-NMDAR AE (n = 13), anti-GAD65 AE (n = 7), or anti-VGKC AE (n = 5). The frequency of neuropsychiatric symptoms present at the onset of illness and time to diagnosis were compared across groups.

RESULTS
Psychiatric symptoms were seen in 92% of patients in our cohort. Depressive features (72%), personality change (64%), psychosis (48%), and catatonia (32%) were the most common psychiatric symptoms exhibited. On average, patients experienced impairment in ≥4 of 7 symptom domains. No patients had isolated psychiatric symptoms. The average times to diagnosis were 1.7, 15.5, and 12.4 months for anti-NMDAR AE, anti-GAD65 AE, and anti-VGKC AE, respectively (P &lt; .001).

CONCLUSIONS
The psychiatric phenotype of AE in children is highly heterogenous. Involving psychiatry consultation services can be helpful in differentiating features of psychosis and catatonia, which may otherwise be misidentified. Patients presenting with psychiatric symptoms along with impairments in other domains should prompt a workup for AE, including testing for all known antineuronal antibodies.
Comparing critical speed modelling approaches and exploring relationships with match-play variables in elite male youth soccer players
Authors: Liu Ka-Chun , Sheard Jake , Piatrikova Eva , Williams Sean , Parr James , Roe Gregory , Kramer Mark , Luna Eva , Milton Paddy , Frixou Theo 
Published: July 2021

Background: A novel bi-exponential method has emerged to estimate critical speed (CS) and D-prime (D′) from a 3-min all- out test (3MT).
Objectives: To compare CS analysis methods to determine whether parameter estimations were interchangeable. Reference values and relationships with key soccer match- play variables were explored.
Methods: Thirteen elite male youth (14-15 years old) players completed a 30 m shuttle run 3MT to estimate CS, D′, rate of speed decline time constant, maximal speed (Smax), time to Smax (tmax), and fatigue index (FI), using the traditional method and bi-exponential model on average (Bi-ExpAverage) and max speed settings (Bi-ExpMax-Speed). High-speed running (HSR) and sprinting distances and counts, and the number of accelerations were collected from two matches. Magnitude- based inferences (p < 0.05) with smallest worthwhile change of 0.2 effect sizes were used to analyse differences. Pearson’s and Spearman’s correlation coefficients were used to measure associations between CS model variables and match-play parameters.
Results: There were significant differences between the traditional method and both bi-exponential models for CS and D′, as well as between the bi-exponential models for all variables except tmax. Using the Bi-ExpAverage model, strong correlations (r = 0.70-0.73; p < 0.05) were observed for D′ and FI with the number of standardised and individualised HSRs, respectively. With the Bi-ExpMax-Speed model, there were strong correlations (r/ρ = 0.64-0.68; p < 0.05) between D′ and the number of standardised HSRs and sprints, and the number of individualised sprints.
Conclusion: There is a lack of interchangeability between analysis methods. It appears that D′ and FI from the bi- exponential models could be associated with high-intensity actions in soccer match-play.
Factors and Routes of Interregional Migration of University Graduates in Russia
Authors: Antosik Liubov , Ivashina Natalya 
Published: July 2021

Data from Russia’s Portal for Monitoring Employment of University Graduates isused to analyze migration of youths between 2013 and 2015. Interregional mobility of human resources stems, in particular, from uneven distribution of universities across the country and socioeconomic disparities between regions. Migration of university graduates may deprive some regions of much of their skilled workers. The largest migration flows are observed between Moscow, St. Petersburg, and Moscow Oblast. Apart from federal cities, graduates are also attracted by industrial regions of the Russian North. This study makes use of a modified gravity model that includes various socioeconomic indicators of home and recipient regions in addition to the basic gravity model factors. Gravity modelling allows identifying a number of migration factors associated with the areas of origin and destination. Origin factors (the ones that push, or repel, graduates out of the region) include low wages and high rates of poverty and unemployment. Destination factors (the ones that pull, or attract, graduates into the region) are represented by high wages and high levels of cultural development and business innovation. Most often, university graduates migrate from south to north and from east to west. Federal subjects of Russia differ essentially by the demand for graduates in regional labor markets. Analysis reveals which regions of Russia attract or repel academic migrants. Territories with consistently diminishing populations of skilled workers are in urgent need for dedicated programs to attract young professionals from other regions, new high-performance jobs, and improvements in the quality of life.
Análisis del proceso de digitalización de un centro de Enseñanza Secundaria desde el modelo DigCompOrg
Authors: Fernández-Miravete Ángel David , Prendes-Espinosa Mª Paz 
Published: July 2021

El logro de una competencia digital entre el alumnado se ha convertido en un objetivo principal dentro de las políticas educativas españolas de las últimas décadas. A este respecto, el Marco Europeo para Organizaciones Educativas Digitalmente Competentes (DigCompOrg) guía a los centros educativos en su proceso de digitalización de forma sistemática. Este trabajo evalúa el uso de las tecnologías de aprendizaje de un centro de enseñanza secundaria de la Región de Murcia (estudio de caso) según las dimensiones contempladas en el modelo europeo. El diseño de la investigación se fundamenta en el modelo ADDIE y escoge una metodología mixta en la que se aplican técnicas de tipo cuantitativo (cuestionario SELFIE) y cualitativo (grupo de discusión). Los resultados que se presentan aquí recogen el análisis de la información cualitativa del alumnado de Enseñanza Secundaria Obligatoria, profesorado y equipo directivo. Esta primera etapa de detección de necesidades ha permitido al centro establecer un proceso de autorreflexión y autoevaluación sobre su proceso de digitalización, así como la propuesta de acciones y estrategias de mejora que refuercen su compromiso con las pedagogías digitales. Entre ellas destaca el desarrollo de una estrategia digital de centro, establecer mecanismos de evaluación del progreso o trabajar con tecnologías de aprendizaje digital que fomenten la autoevaluación y coevaluación, acciones todas ellas relacionadas con las dimensiones de liderazgo y prácticas evaluativas del modelo europeo.
Earthquake prediction: What we have learned and what we should do now
Authors: Evernden Jack F. 
Published: July 2021

abstract
Adopting out of necessity a definition of “earthquake prediction” which stresses short-term warnings (months, weeks, day, and hours), I must conclude that either we are doing the wrong things or such predictions may be impossible. Assuming the former, I recommend major emphasis on direct or nearly direct measurements of stress/strain change in or across fault zones in the immediate vicinity of strong points or “asperities” (how do you find asperities?). This recommendation presupposes essentially total emphasis of the United States' program in California. Even if this recommendation is unpalatable, it is certain that resources now available require a total reanalysis of the present program and a consequent reallocation of funds.
Parametric study of near-field ground motions for oblique-slip and dip-slip dislocation models
Authors: Anderson John G. , Luco J. Enrique 
Published: July 2021

abstractThe near-field motion on the surface of a uniform half-space for oblique-slip and dip-slip faults has been studied by the use of a dislocation model. The fault is modeled by an infinitely long buried dislocation of finite width; rupture propagates horizontally along the fault and past the observation points with a constant rupture velocity lower than the Rayleigh wave velocity. In addition to those parameters which control peak amplitudes near a vertical, strike-slip fault (depth of the top of the fault, horizontal rupture velocity), the dip of the fault plays an important role. The slip direction and the angle between the rupture front and the down-dip direction of the fault also become increasingly important in determining amplitudes of peak ground motions as the dip of the fault decreases from vertical to shallow angles. In some regions near a thrust fault, peak amplitudes are significantly greater than the largest values near a vertical, strike-slip fault.