bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning–enabled Scalable Performance Prediction of Scientific Codes
Authors: Chennupati Gopinath , Santhi Nandakishore , Romero Phill , Eidenbenz Stephan 
Published: April 2021

Hardware architectures become increasingly complex as the compute capabilities grow to exascale. We present the Analytical Memory Model with Pipelines (AMMP) of the Performance Prediction Toolkit (PPT). PPT-AMMP takes high-level source code and hardware architecture parameters as input and predicts runtime of that code on the target hardware platform, which is defined in the input parameters. PPT-AMMP transforms the code to an (architecture-independent) intermediate representation, then (i) analyzes the basic block structure of the code, (ii) processes architecture-independent virtual memory access patterns that it uses to build memory reuse distance distribution models for each basic block, and (iii) runs detailed basic-block level simulations to determine hardware pipeline usage.
PPT-AMMP uses machine learning and regression techniques to build the prediction models based on small instances of the input code, then integrates into a higher-order discrete-event simulation model of PPT running on Simian PDES engine. We validate PPT-AMMP on four standard computational physics benchmarks and present a use case of hardware parameter sensitivity analysis to identify bottleneck hardware resources on different code inputs. We further extend PPT-AMMP to predict the performance of a scientific application code, namely, the radiation transport mini-app SNAP. To this end, we analyze multi-variate regression models that accurately predict the reuse profiles and the basic block counts. We validate predicted SNAP runtimes against actual measured times.
Aspirin in Hepatocellular Carcinoma
Authors: Ricciotti Emanuela , Wangensteen Kirk J. , FitzGerald Garret A. 
Published: April 2021

Abstract
Preclinical and clinical studies provide evidence for aspirin as a preventative agent for cancer. Compelling direct evidence supports a chemopreventive effect of aspirin in individuals at high risk of developing colorectal cancer due to Lynch syndrome, while indirect evidence indicates that aspirin may reduce the risk of and mortality from sporadic colorectal cancer. There is weaker evidence for a protective effect of aspirin against all cancers taken as a group. Nevertheless, the results of recent retrospective cohort studies consistently indicate a beneficial effect of aspirin as a chemopreventive or adjuvant chemotherapeutic agent in hepatocellular carcinoma (HCC). Epidemiologic studies conducted in the general population or in selected populations at higher risk for HCC reveal that regular aspirin use is associated with reduced HCC incidence. In addition, aspirin may act as an adjuvant to other therapies in reducing HCC recurrence. According to studies in animal models, the cancer-preventative effect of aspirin may be related to its antiplatelet and anti-inflammatory activities. Prospective studies are warranted to determine whether aspirin should be recommended to diverse populations of patients at risk for HCC.
Tropomyosin Receptor Kinase Inhibitors for the Treatment of TRK Fusion Cancer
Authors: Laetsch Theodore W. , Hong David S. 
Published: April 2021

AbstractChromosomal rearrangements of NTRK1–3 resulting in gene fusions (NTRK gene fusions) have been clinically validated as oncogenic drivers in a wide range of human cancers. Typically, NTRK gene fusions involve both inter- and intrachromosomal fusions of the 5′ regions of a variety of genes with the 3′ regions of NTRK genes leading to TRK fusion proteins with constitutive, ligand-independent activation of the intrinsic tyrosine kinase. The incidence of NTRK gene fusions can range from the majority of cases in certain rare cancers to lower rates in a wide range of more common cancers. Two small-molecule TRK inhibitors have recently received regulatory approval for the treatment of patients with solid tumors harboring NTRK gene fusions, including the selective TRK inhibitor larotrectinib and the TRK/ROS1/ALK multikinase inhibitor entrectinib. In this review, we consider the practicalities of detecting tumors harboring NTRK gene fusions, the pharmacologic properties of TRK inhibitors currently in clinical development, the clinical evidence for larotrectinib and entrectinib efficacy, and possible resistance mechanisms.
“In the Watermark of Some Margin”: Heidegger’s Other Gesture
Authors: Therezo Rodrigo 
Published: April 2021

Abstract
This paper offers a reflection on the complicated relationship between Derrida and Heidegger, particularly as concerns the issue of difference in their respective thoughts. Taking one of Geschlecht III’s most stunning passages as my point of departure, I walk the reader through some of Derrida’s own remarks on his relationship to Heidegger, before arriving at the différend that seems to exist between them as regards the notion of difference itself. I argue that the margins of Heidegger’s text inscribe a quite radical thinking of difference not at all incompatible with Derridean différance. In conclusion, I turn to Heidegger’s “Anaximander Fragment” where, in the margins of Heidegger’s text, we find a marginal note that, given its content, could surely have been written by Derrida himself.
Faute de frappe: Derrida’s Typos
Authors: Chenoweth Katie 
Published: April 2021

Abstract
“I type very quickly, very badly, with many errors [fautes],” Jacques Derrida confessed in a late interview. This paper proposes that the typographical error – usually viewed as a mere “accident” – may in fact be understood as a productive site for deconstructive reading and thought. Drawing on Nietzsche’s suggestion that the typewriter acts as a “collaborator” in thinking, this paper examines Derrida’s use of the typewriter, with particular attention to his typos. Following Derrida’s reading in the Geschlecht series and his own typographical practice, this paper argues that the typo should be thought of as the condition of possibility of every type – and as a defining difference between Derrida and Heidegger.
Cybernetics for the Social Sciences
Authors: Scott Bernard 
Published: April 2021

Abstract
This publication meets a long-felt need to show the relevance of cybernetics for the social sciences (including psychology, sociology, and anthropology). User-friendly descriptions of the core concepts of cybernetics are provided, with examples of how they can be used in the social sciences. It is explained how cybernetics functions as a transdiscipline that unifies other disciplines and a metadiscipline that provides insights about how other disciplines function. An account of how cybernetics emerged as a distinct field is provided, following interdisciplinary meetings in the 1940s, convened to explore feedback and circular causality in biological and social systems. How encountering cybernetics transformed the author’s thinking and his understanding of life in general, is also recounted.
Asymmetric relationship between ENSO and the tropical Indian Ocean summer SST anomalies
Authors: Wu Xiangbai , Li Gen , Jiang Wenping , Long Shang-Min , Lu Bo 
Published: April 2021

AbstractDuring the summer following El Niño, a basin-wide sea surface temperature (SST) warming takes place over the tropical Indian Ocean (TIO), exerting profound influences on the Asian summer monsoon. This is an important source of seasonal predictability for the Asian summer monsoon. Based on observations, however, the present study finds that the relationship between El Niño-Southern Oscillation (ENSO) and the TIO SST anomalies during the decaying summer is asymmetric with a much weaker relationship between La Niña and the TIO SST anomalies relative to El Niño. The analyses show that this asymmetric relationship can be explained by the asymmetries in initial TIO SST, oceanic Rossby wave in the southern Indian Ocean and ENSO decaying rate. In contrast to El Niño events, La Niña events tend to have a stronger initial TIO warming and a less peak intensity with a weaker oceanic Rossby wave response in the southern Indian Ocean. On the other hand, La Niña events tend to decay more slowly with the persistent SST cooling over the central equatorial Pacific in the following summer. The equatorial Pacific SST cooling would induce an anomalous anticyclone via a Gill-type Rossby wave response, weakening the positive feedback between the anomalous cyclone spanning the tropical Northwest Pacific and North Indian oceans and the TIO summer basin-wide SST cooling. These results have important implications for the climate predictability of the Indian Ocean and Asian summer monsoon.
The Importance of Central Pacific Meridional Heat Advection to the Development of ENSO
Authors: Wen Caihong , Kumar Arun , Heureux Michelle L’ , Xue Yan , Becker Emily 
Published: April 2021

AbstractThe relationship between the Warm Water Volume (WWV) ENSO precursor and ENSO SST weakened substantially after ~2000, coinciding with a degradation in dynamical model ENSO prediction skill. It is important to understand the drivers of the equatorial thermocline temperature variations and their linkage to ENSO onsets. In this study, a set of ocean reanalyses is employed to assess factors responsible for the variation of the equatorial Pacific Ocean thermocline during 1982-2019. Off-equatorial thermocline temperature anomalies carried equatorward by the mean meridional currents associated with Pacific Tropical Cells are shown to play an important role in modulating the central equatorial thermocline variations, which is rarely discussed in the literature. Further, ENSO events are delineated into two groups based on precursor mechanisms: the western equatorial type (WEP) ENSO, when the central equatorial thermocline is mainly influenced by the zonal propagation of anomalies from the western Pacific, and the off-equatorial central Pacific (OCP) ENSO, when off-equatorial central thermocline anomalies play the primary role. WWV is found to precede all WEP ENSO by 6-9 months, while the correlation is substantially lower for OCP ENSO events. In contrast, the central tropical Pacific (CTP) precursor, which includes off-equatorial thermocline signals, has a very robust lead correlation with the OCP ENSO. Most OCP ENSO events are found to follow the same ENSO conditions, and the number of OCP ENSO increases substantially since the 21st century. These results highlight the importance of monitoring off-equatorial subsurface preconditions for ENSO prediction and to understand multi-year ENSO.
The Effect of an Equatorial Continent on the Tropical Rain Belt. Part 1: Annual Mean Changes in the ITCZ
Authors: Biasutti Michela , Russotto Rick D. , Voigt Aiko , Blackmon-Luca Charles C. 
Published: April 2021

AbstractThe Tropical Rain belts with an Annual cycle and Continent Model Intercomparison Project (TRACMIP) ensemble includes slab-ocean aquaplanet controls and experiments with a highly idealized tropical continent: modified aquaplanet grid cells with increased evaporative resistance, increased albedo, reduced heat capacity, and no ocean heat transport (zero Q-flux). In the annual mean, an equatorial cold tongue develops west of the continent and induces dry anomalies and a split in the oceanic ITCZ. Ocean cooling is initiated by advection of cold, dry air from the winter portion of the continent; warm, humid anomalies in the summer portion are restricted to the continent by anomalous surface convergence. The surface energy budget suggests that ocean cooling persists and intensifies because of a positive feedback between a colder surface, drier and colder air, reduced downwelling long wave (LW) flux, and enhanced net surface LW cooling (LW feedback). A feedback between wind, evaporation, and SST (WES feedback) also contributes to the establishment and maintenance of the cold tongue. Simulations with a grayradiation model and simulations that diverge from protocol (with negligible winter cooling) confirm the importance of moist-radiative feedbacks and of rectification effects on the seasonal cycle. This mechanism coupling the continental and oceanic climate might be relevant to the double ITCZ bias. The key role of the LW feedback suggests that the study of interactions between monsoons and oceanic ITCZs requires full-physics models and a hierarchy of land models that considers evaporative processes alongside heat capacity as a defining characteristic of land.
Course trajectories of anxiety disorders: Results from a 6-year follow-up in a general population study
Authors: Schopman Simone ME , ten Have Margreet , van Balkom Anton J , de Graaf Ron , Batelaan Neeltje M 
Published: April 2021

Objective: Little is known about the course of anxiety disorders in the general population. This study provides insights into the course of anxiety disorders in the general population taking into account transition to residual symptoms and to other diagnostic categories. Methods: Using data from three waves of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2; n = 6646), subjects with anxiety disorders (T0; n = 243) were divided into three mutually exclusive course trajectories according to their diagnostic status at 3-year (T1) and 6-year (T2) follow-up: remission group (no disorder at T2), intermittent course group (no disorder at T1 and disorder at T2) and chronic course group (disorder at all measurements). Transition to residual symptoms or other psychopathology were studied. In addition, predictors of course trajectories were assessed. Results: During 6-year follow-up, 77.8% of subjects achieved remission, 14.0% followed an intermittent course and 8.2% a chronic course. Of those in remission, residual anxiety symptoms remained in 46.6%, while 7.9% developed another disorder between T0 and T2. Compared with the remitting group, a chronic course was predicted by not living with a partner, multiple negative life events, neuroticism, lower mental functioning, severity of anxiety symptoms, use of mental health care and medication use. Limitations: The intermittent and chronic course groups were small, limiting statistical power. As a result, certain predictors may not have reached significance. Conclusions: In the general population at 6-year follow-up, 77.8% of subjects with anxiety disorders achieved remission. Because of transition to residual symptoms or another diagnostic category, only 52.4% of those subjects had a true favourable outcome.
Research on the structural model of the perception scale of Assessment for Learning in college students’ PE class
Authors: Ye Jian-Fei , Chen Xin , Zhu Wei-Qiang , Dai Chang-Sheng 
Published: April 2021

Objective Under the guidance of the basic theory of AFL, a scientific and targeted measuring tool was initially developed to measure the perceived degree of college students’ Assessment for learning in physical education classroom and serve as an important basis for the implementation of AFL in physical education classroom. Methods according to the scale of the content framework, on the basis of expert interview and the inherent characteristics of AFL in the physical education classroom to form the initial questionnaire, used early 487 college students as object to the initial questionnaire for project analysis, to form the formal questionnaire, we used 391 college students as formal subjects was carried out the formal questionnaire by exploratory factor analysis and confirmatory factor analysis, test reliability and validity, to form the Perception Scale of AFL in College Students’ PE Class. Results The perception scale of AFL in College Students’ PE Class included 27 items, which were divided into four dimensions of learning diagnosis, goal clarification, process experience and result scaffold, which accounted for 64.253% of the total variation. Confirmatory factor analysis showed that the fitting index was good (2/DF =2.819, GFI = 0.905, AGFI = 0.912, IFI = 0.905, CFI = 0.926, NFI = 0.943, RMSEA = 0.056). The overall internal consistency of the questionnaire was 0.895, the coefficients of each dimension were between 0.863 and 0.917, and the retest reliability was between 0.834 and 0.912. The scale as a whole has high calibration positive validity. Conclusion The Perception Scale of AFL in College Students’ PE Class compiled by this research has good differentiation, reliability and validity, and can be used as a measuring tool for Chinese college students’ perceived assessment for learning in physical education classroom.
An efficient and label-free LC-MS/MS method for assessing drug’s activity at dopamine and serotonin transporters using transporter-transfected HEK293T cells
Authors: Lin Zebin , Liu Chenyang , Fan Enshan , Zhang Yurong , Zheng Shuiqing , Rao Yulan 
Published: April 2021

Background: Dopamine transporter (DAT) and serotonin transporter (SERT) are targets for many psychoactive substances. Functional assays including uptake inhibition and release assays often involve radiolabeled compounds like [3H]-dopamine and [3H]-serotonin to assess drug activity at transporters, which have high requirements on handling radioactive samples. Aims: The aim of this study was to establish a label-free method to assess drug activity at DAT and SERT. Methods: A liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was established using transporter-transfected human embryonic kidney 293T (HEK293T) cells. This method was evaluated by testing the effects of amphetamine and cocaine in the assay procedure. Results: The limits of detection of this method were 0.2 nM for both dopamine (DA) and serotonin (5-HT), with good linearities in the range of 0.5–160 nM. Amphetamine and cocaine’s IC50 and EC50 on DAT and SERT determined by this method were consistent with previous reports. Conclusions: A rapid, reliable and label-free LC-MS/MS method for assessing drug activity was established, which affords an attractive alternative for those laboratories that do not have a radiation license or capabilities.
Myocardium microcirculation study in a healthy Chinese population using 3.0-T cardiac magnetic resonance intravoxel incoherent motion imaging
Authors: Li Shilan , Mou Anna , Li Xin , Guo Yan , Song Qingwei , Liu Ailian , Li Zhiyong 
Published: April 2021

Background Intravoxel incoherent motion imaging (IVIM) can non-invasively evaluate diffusion and microvascular perfusion. Purpose To explore the myocardium microcirculation of a healthy Chinese population by using cardiac magnetic resonance (CMR) IVIM. Material and Methods A total of 80 healthy volunteers (44 men, 36 women) who underwent 3.0-T CMR examination were enrolled. All participants had cardiac cine imaging and short-axis CMR-IVIM of the left ventricle (LV) using multiple b-values. The consistency of the IVIM parameters was assessed by intraclass correlation coefficient (ICC) and the Bland–Altman test. Spearman correlation analysis was performed between IVIM parameters and age, and body mass index (BMI). The differences of IVIM parameters were analyzed between gender and different ages. Results LV end-diastolic volume (EDV), end-systolic volume (ESV), LVmass, cardiac output (CO), and BMI in the male group were higher than those in the female group ( P<0.05). IVIM parameters had good intra-observer and inter-observer consistency (≥0.75). Bland–Altman analysis also showed good intra-observer and inter-observer consistency. ADCfast decreased with increasing female age (rs = –0.37; P = 0.01), while IVIM parameters had no correlation with BMI regardless of sex. ADCfast in the female group had a statistical difference between different age groups. The ADCslow and f in the male group were lower than those in the female group ( P<0.05); however, there was no statistical difference in ADCfast between genders. Conclusion IVIM parameters in healthy Chinese volunteers provided good consistency. There was a negative correlation between ADCfast and age in the female group.
Patterns of aggressiveness: risk of progression to invasive breast cancer by mammographic features of calcifications in screen-detected ductal carcinoma in situ
Authors: Lilleborge Marie , Falk Ragnhild S , Hovda Tone , Holmen Marit M , Ursin Giske , Hofvind Solveig 
Published: April 2021

Background Mammographic features of calcifications on mammograms showing invasive breast cancer are associated with survival. Less is known about mammographic features and progression to invasive breast cancer among women treated for ductal carcinoma in situ (DCIS). Purpose To investigate mammographic features of calcifications in screen-detected DCIS in women who later did and did not get diagnosed with invasive breast cancer. Material and Methods This registry-based nested case-control study analyzed data from women with screen-detected DCIS in BreastScreen Norway, 1995–2016. Within this cohort of women with DCIS, those who were later diagnosed with invasive breast cancer (cases) were matched (1:2) to women who were not diagnosed with invasive breast cancer (controls) after their DCIS and by the end of 2016. Information on mammographic features were collected by a national radiological review, where screening mammograms were reviewed locally at each of the 16 breast centers in Norway. We used conditional logistic regression analysis to estimate associations between mammographic features of calcifications in the DCIS mammogram and the risk of subsequent invasive breast cancer. Results We found a higher risk of invasive breast cancer associated with fine linear branching (casting) morphology (odds ratio 20.0; 95% confidence interval [CI] 2.5–158.9) compared to fine linear or fine pleomorphic morphology. Regional or diffuse distribution showed an odds ratio of 2.8 (95% CI 1.0–8.2) compared to segmental or linear distribution. Conclusion Mammographic features of calcifications in screen-detected DCIS were of influence on the risk of invasive breast cancer. Unfavorable characteristics of DCIS were fine linear branching morphology, and regional or diffuse distribution.
Efficacy and safety of radiofrequency ablation for treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials
Authors: Zhang Hua , Wang Bo , He Jie , Du Zhongju 
Published: April 2021

Objective To evaluate the efficacy and safety of radiofrequency ablation for the treatment of knee osteoarthritis. Methods A literature review was conducted using the PubMed, Cochrane Review, Embase, and Google Scholar databases. Two reviewers independently assessed the eligibility of all retrieved studies. The research was reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure the reliability and verity of the results. The statistical analysis was performed using STATA version 13.0. Results Nine randomized controlled trials were collected for the data extraction and meta-analysis. Significant differences in the pain score at 4, 12, and 24 weeks were found between patients treated with radiofrequency ablation and those treated with placebo. Furthermore, the use of radiofrequency ablation was associated with an improved outcome of the Western Ontario and McMaster Universities Arthritis Index at 4, 12, and 24 weeks. No serious adverse events were observed in any patients who underwent radiofrequency ablation. Conclusion Radiofrequency ablation is efficacious and safe for reducing pain and improving knee function in patients with knee osteoarthritis, without increasing the risk of adverse effects.