bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unreferenced spatial localization under monocular and dichoptic viewing conditions
Authors: Karsolia Apoorva , Stevenson Scott B. , Das Vallabh E. 
Published: November 2021

AbstractKnowledge of eye position in the brain is critical for localization of objects in space. To investigate the accuracy and precision of eye position feedback in an unreferenced environment, subjects with normal ocular alignment attempted to localize briefly presented targets during monocular and dichoptic viewing. In the task, subjects’ used a computer mouse to position a response disk at the remembered location of the target. Under dichoptic viewing (with red (right eye)–green (left eye) glasses), target and response disks were presented to the same or alternate eyes, leading to four conditions [green target–green response cue (LL), green–red (LR), red–green (RL), and red–red (RR)]. Time interval between target and response disks was varied and localization errors were the difference between the estimated and real positions of the target disk. Overall, the precision of spatial localization (variance across trials) became progressively worse with time. Under dichoptic viewing, localization errors were significantly greater for alternate-eye trials as compared to same-eye trials and were correlated to the average phoria of each subject. Our data suggests that during binocular dissociation, spatial localization may be achieved by combining a reliable versional efference copy signal with a proprioceptive signal that is unreliable perhaps because it is from the wrong eye or is too noisy.
Cardiovascular morbidities in postoperative colorectal cancer patients
Authors: Kim Hyangkyoung , Park In Ja , Han Youngjin , Kwon Tae-Won , Cho Yong-Pil 
Published: November 2021

AbstractThis retrospective observational study investigated the long-term prevalence of new-onset cardiovascular disease (CVD) and the predictive role of atherosclerotic plaque in the aorta and iliac arteries for CVD in postoperative colorectal cancer (CRC) patients who received surgical treatment between 2014 and 2015. CVD included coronary or cerebrovascular diseases which required treatment and new-onset CVD included peri-and postoperatively diagnosed CVDs or aggravated CVDs that required additional treatment during follow-up. Of the 2,875 patients included in this study, the prevalence of CVD was 8.9% (255/2875) and 141 (4.9%) developed new-onset CVD. Maximum arterial stenosis in the aorta or iliac arteries occurred in 40.8 ± 18.6% of patients with new-onset CVD and 11.6 ± 13.8% of patients without new-onset CVD (p < 0.001). The mean new-onset CVD-free survival time in patients with > 30% and < 30% stenoses were 52.5 [95% confidence intervals (CIs) 50.0–54.9] and 66.5 (95% CIs 66.2–66.8) months, respectively (p < 0.001). The area under the receiver operating characteristic curve of the maximal arterial stenosis for new-onset CVD was 0.911. These results suggest that CRC patients are at risk for developing new-onset CVD, which is associated with reduced survival. Atherosclerotic burden in the aorta or both iliac arteries may help predict future CVD events.
Automatic integration of numerical formats examined with frequency-tagged EEG
Authors: Marinova Mila , Georges Carrie , Guillaume Mathieu , Reynvoet Bert , Schiltz Christine , Van Rinsveld Amandine 
Published: November 2021

AbstractHow humans integrate and abstract numerical information across different formats is one of the most debated questions in human cognition. We addressed the neuronal signatures of the numerical integration using an EEG technique tagged at the frequency of visual stimulation. In an oddball design, participants were stimulated with standard sequences of numbers (< 5) depicted in single (digits, dots, number words) or mixed notation (dots—digits, number words—dots, digits—number words), presented at 10 Hz. Periodically, a deviant stimulus (> 5) was inserted at 1.25 Hz. We observed significant oddball amplitudes for all single notations, showing for the first time using this EEG technique, that the magnitude information is spontaneously and unintentionally abstracted, irrespectively of the numerical format. Significant amplitudes were also observed for digits—number words and number words—dots, but not for digits—dots, suggesting an automatic integration across some numerical formats. These results imply that direct and indirect neuro-cognitive links exist across the different numerical formats.
An mCARE study on patterns of risk and resilience for children with ASD in Bangladesh
Authors: Rabbani Masud , Haque Munirul M. , Das Dipal Dipranjan , Zarif Md Ishrak Islam , Iqbal Anik , Schwichtenberg Amy , Bansal Naveen , Soron Tanjir Rashid , Ahmed Syed Ishtiaque , Ahamed Sheikh Iqbal 
Published: November 2021

AbstractCommunity-wide lockdowns in response to COVID-19 influenced many families, but the developmental cascade for children with autism spectrum disorder (ASD) may be especially detrimental. Our objective was to evaluate behavioral patterns of risk and resilience for children with ASD across parent-report assessments before (from November 2019 to February 2020), during (March 2020 to May 2020), and after (June 2020 to November 2020) an extended COVID-19 lockdown. In 2020, our study Mobile-based care for children with ASD using remote experience sampling method (mCARE) was inactive data collection before COVID-19 emerged as a health crisis in Bangladesh. Here we deployed “Cohort Studies”, where we had in total 300 children with ASD (150 test group and 150 control group) to collect behavioral data. Our data collection continued through an extended COVID-19 lockdown and captured parent reports of 30 different behavioral parameters (e.g., self-injurious behaviors, aggression, sleep problems, daily living skills, and communication) across 150 children with ASD (test group). Based on the children’s condition, 4–6 behavioral parameters were assessed through the study. A total of 56,290 behavioral data points was collected (an average of 152.19 per week) from parent cell phones using the mCARE platform. Children and their families were exposed to an extended COVID-19 lockdown. The main outcomes used for this study were generated from parent reports child behaviors within the mCARE platform. Behaviors included of child social skills, communication use, problematic behaviors, sensory sensitivities, daily living, and play. COVID-19 lockdowns for children with autism and their families are not universally negative but supports in the areas of “Problematic Behavior” could serve to mitigate future risk.
A semi-automated, isolation-free, high-throughput SARS-CoV-2 reverse transcriptase (RT) loop-mediated isothermal amplification (LAMP) test
Authors: Schmidt Jonas , Berghaus Sandro , Blessing Frithjof , Wenzel Folker , Herbeck Holger , Blessing Josef , Schierack Peter , Rödiger Stefan , Roggenbuck Dirk 
Published: November 2021

AbstractShortages of reverse transcriptase (RT)-polymerase chain reaction (PCR) reagents and related equipment during the COVID-19 pandemic have demonstrated the need for alternative, high-throughput methods for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mass screening in clinical diagnostic laboratories. A robust, SARS-CoV-2 RT-loop-mediated isothermal amplification (RT-LAMP) assay with high-throughput and short turnaround times in a clinical laboratory setting was established and compared to two conventional RT-PCR protocols using 323 samples of individuals with suspected SARS-CoV-2 infection. Limit of detection (LoD) and reproducibility of the isolation-free SARS-CoV-2 RT-LAMP test were determined. An almost perfect agreement (Cohen’s kappa > 0.8) between the novel test and two classical RT-PCR protocols with no systematic difference (McNemar’s test, P > 0.05) was observed. Sensitivity and specificity were in the range of 89.5 to 100% and 96.2 to 100% dependent on the reaction condition and the RT-PCR method used as reference. The isolation-free RT-LAMP assay showed high reproducibility (Tt intra-run coefficient of variation [CV] = 0.4%, Tt inter-run CV = 2.1%) with a LoD of 95 SARS-CoV-2 genome copies per reaction. The established SARS-CoV-2 RT-LAMP assay is a flexible and efficient alternative to conventional RT-PCR protocols, suitable for SARS-CoV-2 mass screening using existing laboratory infrastructure in clinical diagnostic laboratories.
Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator
Authors: Saeedi Ahmed , Cummings Nicola J. , McLean Denise , Connerton Ian F. , Connerton Phillippa L. 
Published: November 2021

AbstractA novel Gram-stain negative, aerobic, halotolerant, motile, rod-shaped, predatory bacterium ASxL5T, was isolated from a bovine slurry tank in Nottinghamshire, UK usingCampylobacter hyointestinalisas prey. OtherCampylobacterspecies and members of theEnterobacteriaceaewere subsequently found to serve as prey. Weak axenic growth on Brain Heart Infusion agar was achieved upon subculture without host cells. The optimal growth conditions were 37 °C, at pH 7. Transmission electron microscopy revealed some highly unusual morphological characteristics related to prey availability. Phylogenetic analyses using 16S rRNA gene sequences showed that the isolate was related to members of theOceanospirillaceaefamily but could not be classified clearly as a member of any known genus. Whole genome sequencing of ASxL5Tconfirmed the relationship to members theOceanospirillaceae. Database searches revealed that several ASxL5Tshare 16S rRNA gene sequences with several uncultured bacteria from marine, and terrestrial surface and subsurface water. We propose that strain ASxL5Trepresents a novel species in a new genus. We propose the nameVenatorbacter cucullusgen. nov., sp. nov. with ASxL5Tas the type strain.
The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response
Authors: Rozalski Rafal , Gackowski Daniel , Skalska-Bugala Aleksandra , Starczak Marta , Siomek-Gorecka Agnieszka , Zarakowska Ewelina , Modrzejewska Martyna , Dziaman Tomasz , Szpila Anna , Linowiecka Kinga , Guz Jolanta , Szpotan Justyna , Gawronski Maciej , Labejszo Anna , Gackowska Lidia , Foksinski Marek , Olinska Elwira , Wasilow Aleksandra , Koltan Andrzej , Styczynski Jan , Olinski Ryszard 
Published: November 2021

AbstractThe active DNA demethylation process may be linked to aberrant methylation and may be involved in leukemogenesis. We investigated the role of epigenetic DNA modifications in childhood acute lymphoblastic leukemia (ALL) diagnostics and therapy monitoring. We analyzed the levels of 5-methyl-2′-deoxycytidine (5-mdC) oxidation products in the cellular DNA and urine of children with ALL (at diagnosis and during chemotherapy, n = 55) using two-dimensional ultra-performance liquid chromatography with tandem mass spectrometry (2D UPLC–MS/MS). Moreover, the expression of Ten Eleven Translocation enzymes (TETs) at the mRNA and protein levels was determined. Additionally, the ascorbate level in the blood plasma was analyzed. Before treatment, the ALL patients had profoundly higher levels of the analyzed modified DNA in their urine than the controls. After chemotherapy, we observed a statistically significant decrease in active demethylation products in urine, with a final level similar to the level characteristic of healthy children. The level of 5-hmdC in the DNA of the leukocytes in blood of the patient group was significantly lower than that of the control group. Our data suggest that urinary excretion of epigenetic DNA modification may be a marker of pediatric ALL status and a reliable marker of chemotherapy response.
Microfluidic transfection of mRNA into human primary lymphocytes and hematopoietic stem and progenitor cells using ultra-fast physical deformations
Authors: Loo Jocelyn , Sicher Ian , Goff Ailin , Kim Ockchul , Clary Nicole , Alexeev Alexander , Sulchek Todd , Zamarayeva Alla , Han Sewoon , Calero-Garcia Miguel 
Published: November 2021

AbstractMessenger RNA (mRNA) delivery provides gene therapy with the potential to achieve transient therapeutic efficacy without risk of insertional mutagenesis. Amongst other applications, mRNA can be employed as a platform to deliver gene editing molecules, to achieve protein expression as an alternative to enzyme replacement therapies, and to express chimeric antigen receptors (CARs) on immune cells for the treatment of cancer. We designed a novel microfluidic device that allows for efficient mRNA delivery via volume exchange for convective transfection (VECT). In the device, cells flow through a ridged channel that enforces a series of ultra-fast and large intensity deformations able to transiently open pores and induce convective transport of mRNA into the cell. Here, we describe efficient delivery of mRNA into T cells, natural killer (NK) cells and hematopoietic stem and progenitor cells (HSPCs), three human primary cell types widely used for ex vivo gene therapy applications. Results demonstrate that the device can operate at a wide range of cell and payload concentrations and that ultra-fast compressions do not have a negative impact on T cell function, making this a novel and competitive platform for the development of ex vivo mRNA-based gene therapies and other cell products engineered with mRNA.
In vivotherapeutic exploring forMori foliumextract against type 2 diabetes mellitus in rats
Authors: Lyu Kaibo , Yue Wei , Ran Junhua , Liu Yunjuan , Zhu Xueliang 
Published: November 2021

AbstractBackground: The study was aimed to investigate the potential therapeutic effect of Mori folium aqueous extracts (MFAE) on type 2 diabetes mellitus (T2DM) in vivo.Methods and results: A rat model of T2DM was established with the combination of high sugar and high-fat diet (HSFD) and streptozotocin (STZ). The T2DM rats were administrated with low (2 g.kg−1) and high (5 g.kg−1) doses of MFAE for 60 consecutive days. The biochemical indices of glucose metabolism disorders, insulin resistance and oxidative stress were observed. The results indicated that MFAE significantly promoted the synthesis of hepatic glycogen, reduced the levels of fasting blood glucose and fasting blood insulin, and improved the insulin sensitivity index (ISI). MFAE administration also remarkably increased the levels of superoxide dismutase (SOD) and reduced the levels of malondialdehyde (MDA).Conclusion: MFAE showed a therapeutic effect on T2DM with the bioative effect of improve glucose metabolism disorders, decrease insulin resistance, and ameliorate the antioxidative ability.
Modelling and performance evaluation of diode‐assisted impedance source networks
Authors: Rezazadeh Hamed , Monfared Mohammad , Nikbahar Ali 
Published: November 2021

AbstractThis paper deals with a family of two‐ and three‐windings coupled inductor‐based impedance source networks. They have been basically derived from the successful quasi‐Y‐source network (q‐YSN) by replacing one of its capacitors with a diode with different combinations of coupled inductors and called diode assisted impedance source networks (DA‐ISNs). The general three‐windings version, called diode‐assisted Y‐source network (DA‐YSN), as the origin of all other simplified versions, is thoroughly investigated from various points of view. From the voltage gain characteristics aspect, it offers a higher voltage gain with the same number of elements as the conventional q‐YSN. Lower magnetizing and input current ripples show the higher power density of DA‐YSN in comparison to q‐YSN. The effectively reduced voltage stress and the total value of capacitors, and a considerable decreased conversion loss of the magnetic element are the other attractive features of DA‐YSN. With the advantages of a low input current ripple and a high voltage gain, DA‐ISNs can be suitable choices for renewable energy and distributed power generation systems. Operating principle, circuit analysis, and parameters design guidelines for DA‐YSN are thoroughly investigated. Also, the small‐signal modelling, analysis and the controller design are presented in this paper. Finally, the theoretical properties of DA‐YSN are scrutinized by performing extensive experiments on a 200 W laboratory prototype.
Aging temperature role on precipitation hardening in a non-equiatomic AlCoCrFeNiTi high-entropy alloy
Authors: Nandal Vickey , Hariharan K. , Sarvesha R. , Singh Sudhanshu S. , Huang E.-Wen , Chang Yao-Jen , Yeh An-Chou , Neelakantan Suresh , Jain Jayant 
Published: November 2021

In the present study, the influence of aging temperature on precipitation hardening in a non-equiatomic Al0.2Co1.5CrFeNi1.5Ti0.3 high-entropy alloy has been evaluated. The aging curves have been deduced for different aging temperatures (650, 750, and 850°C) as a function of time. The aging response was found to be markedly different with varying aging temperatures. A combined FESEM and transmission electron microscope studies have been performed to understand the evolution of precipitates and their characteristics with aging temperature and time. The variation of precipitate morphology, number density and size of precipitates with aging temperature were correlated with the age-hardening response. Additionally, the role of lattice misfit strain on precipitate morphology has been evaluated. GRAPHICAL ABSTRACT
L-cysteine functionalized graphene quantum dots for sub-ppb detection of As (III)
Authors: Naseh Md Farhan , Singh Neelam , Ansari Jamilur R , Kumar Ashavani , Sarkar Tapan , Datta Anindya 
Published: November 2021

Abstract
Here, we report functionalized graphene quantum dots (GQDs) for the optical detection of arsenic at room temperature. GQDs with the fluorescence of three fundamental colors (red, green, and blue) were synthesized and functionally capped with L-cysteine (L-cys) to impart selectively towards As (III) by exploiting the affinity of L-cys towards arsenite. The optical characterization of GQDs was carried out using UV–vis absorption spectroscopy, Fourier transform infrared spectroscopy, and fluorescence spectrometry, and the structural characterizations were performed using transmission electron microscopy. The fluorescence results showed instantaneous quenching in intensity when the GQDs came in contact with As (III) for all test concentrations over a range from 0.025 to 25 ppb, which covers the permissible limit of arsenic in drinking water. The experimental results suggested excellent sensitivity and selectivity towards As (III).
Two-dimensional ZnS@N-doped carbon nanoplates for complete lithium ion batteries
Authors: Jiang Heng , Zhang Jie , Zeng Yibo , Chen Yanli , Guo Hang , Li Lei , Chen Xin , Zhang Ying 
Published: November 2021

Abstract
Metal sulfides are promising anode materials for lithium ion batteries because of the high specific capacities and better electrochemical kinetics comparing to their oxide counterparts. In this paper, novel monocrystalline wurtzite ZnS@N-doped carbon (ZnS@N–C) nanoplates, whose morphology and phase are different from the common ZnS particles with cubic phase, are successfully synthesized. The ZnS@N–C nanoplates exhibit long cycle life with a high reversible specific capacity of 536.8 mAh · g−1 after 500 cycles at a current density of 500 mA · g−1, which is superior to the pure ZnS nanoplates, illustrating the obvious effect of the N-doped carbon coating for mitigating volume change of the ZnS nanoplates and enhancing the electronic conductivity during charge/discharge processes. Furthermore, it is revealed that the ZnS single crystals with wurtzite phase in the ZnS@N–C nanoplates are transformed to the polycrystalline cubic phase ZnS after charge/discharge processes. In particular, the ZnS@N–C nanoplates are combined with the commercial LiNi0.6Co0.2Mn0.2O2 cathode to fabricate a new type of LiNi0.6Co0.2Mn0.2O2/ZnS@N–C complete battery, which exhibits good cycling durability up to 120 cycles at a charge/discharge rate of 1 C after the prelithiation treatment on the ZnS@N–C anode, highlighting the potential of the ZnS@N–C nanoplates anode material applied in lithium ion battery.
ZIF-67-derived N-doped double layer carbon cage as efficient catalyst for oxygen reduction reaction
Authors: Zhang Wenwen , Zhao Ximeng , Niu Weixing , Yu Hang , Wan Tongtao , Liu Guihua , Zhang Dongsheng , Wang Yanji 
Published: November 2021

Abstract
The slow kinetic of oxygen reduction reaction (ORR) hampers the practical application of energy conversion devices, such as fuel cells, metal-air batteries. Here, an efficient ORR electrocatalyst consists of Co, Ni co-decorated nitrogen-doped double shell hollow carbon cage (Ni–Co@NHC) was fabricated by pyrolyzing Ni-doped polydopamine wrapped ZIF-67. During the preparation, polydopamine served as a protective layer can effectively prevent the aggregation of Co and Ni nanoparticles during the pyrolysis process, and at the same time forming a carbon layer to grow a double layer carbon cage. This unique hollow structure endows the catalyst with a high specific surface area as well as more exposed active sites. Also benefited from the synergistic effect between Ni and Co nanoparticles, the Ni–Co@NHC catalyst leads to an outstanding ORR performance of half-wave potential (E
1/2, 0.862 V), outperforms that of commercial Pt/C catalyst. Additionally, when Ni–Co@NHC was used in the cathode for the zinc-air battery, the cell exhibits high power density (108 mW cm−2) and high specific capacity (806 mAh g−1) at 20 mA cm−2 outperforming Pt/C. This work offers a promising design strategy for the development of high-performance ORR electrocatalysts.
Effects of gas adsorbed on solid surface during gas breakdown in electron cyclotron resonance discharges
Authors: Fu S H , Ding Z F 
Published: November 2021

Abstract
The microwave breakdown power (P
wb) in an ECR plasma source was not merely determined by pressure (gas flow rate), but found to vary with the time interval between two successive breakdowns. The measured P
wb dropped rapidly from a high value at a short time interval to a low level at a long time interval. The obtained dependence of P
wb on pressure (gas flow rate) exhibited distinct features: the normal monotonicity and abnormal non-monotonicity at the short and long time intervals, respectively. The effective zone in the antenna’s surface, bombarded by hot electrons heated in the ECR layer, was validated by (1) masking the antenna with a film having a variable radius; (2) calculating the distribution of the vertical component of the microwave electric field with respect to the static magnetic field; and (3) imaging glows of transient breakdown discharges with a fast camera. The reduction in P
wb was mainly attributed to the enhanced emission of δ-electrons from the gas-adsorbed antenna under the bombardment of energetic electrons coming from the ECR layer. The correlation between the dynamic gas coverage and the emission coefficient of δ-electrons was established to understand the abnormal ECR breakdown features.