bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Self-Efficacy-Enhancing Intervention for Chinese Patients after Total Hip Arthroplasty: Study Protocol for A Randomized Controlled Trial with 6-Month Follow-Up
Authors: Deng Bo , Chen Yu mei , Zhang Mei fen , Meng Ya , Zhang Yi heng , Tan Xing xian , Zhou Xiao hong 
Published: May 2021

Abstract
Background: Total hip arthroplasty (THA) is a common and effective surgical method for advanced hip arthritis. Rehabilitation exercises are important to improve joint function after THA and are usually conducted in a home-based program. Poor patient adherence limits improvements in pain and function, affecting quality of life. The increasing use of THA in the aging Chinese population underscores the need to develop strategies that maximize functional outcomes. The purpose of this pilot study is to develop and assess the feasibility of a self-efficacy-enhancing intervention (SEEI) to improve exercise adherence in patients undergoing THA. Methods: This single-blinded, parallel, randomized control trial will recruit 150 patients after THA and randomly assign them to an intervention or control group using computer-generated block randomization. The control group will receive usual care using evidence-based guidelines. The intervention group will receive the 6-month SEEI comprising personalized exercise guidance and self-efficacy education delivered using one face-to-face education session and four telephone consultations, supplemented by written materials. Participants are encouraged to build confidence in their own abilities, set rehabilitation goals, and self-monitor their physical exercise. Results: Assessments will be conducted at baseline, and 1, 3, and 6 months postsurgery. The outcome indicators are exercise adherence, physical function, anxiety and depression, self-efficacy of rehabilitation, joint function, and quality of life.Conclusions: This study will test a theory-based intervention program to improve self-efficacy in rehabilitation, which may significantly impact out-of-hospital rehabilitation. The results will provide evidence to inform the postoperative recovery of patients undergoing THA or similar procedures.Trial registration: Chinese Clinical Trials Registry (ChiCTR2000029422), registered 31 January 2020.
A New Classification of Talocalcaneal Coalitions Based On Computed Tomography For Operative Planning
Authors: Wang Anhong , Shi Weili , Chen Linxin , Xie Xing , Zhao Feng , Pi Yanbin , Jiao Chen , Hu Yuelin , Jiang Dong , Guo Qinwei 
Published: May 2021

Abstract
Background Current classifications emphasize the morphology of the coalition, however, subtalar joint facets involved should also be emphasized.Objective The objective of this study was to develop a new classification system based on the articular facets involved to cover all coalitions and guide operative planning.Methods Patients were diagnosed with talocalcaneal coalition using a CT scan, between January 2009 and February 2021. We classified the coalition into four main types according to the shape and nature of the coalition: I, inferiorly overgrown talus or superiorly overgrown calcaneus; II, both talus and calcaneus overgrew; III, coalition with an accessory ossicle; (I-III types are non-osseous coalition) IV, complete osseous coalition. Then each type was further divided into three subtypes according to the articular facets involved. A, the coalition involving the anterior facets; M, the coalition involving the middle facets, and P, the coalition involving the posterior facets.Results There were 106 patients (108 feet) included in this study. Overall, 8 feet (7.5%) were classified as type I, 75 feet (69.4%) as type II, 7 feet (6.5%) as type III, and 18 feet (16.7%) as type IV. Twenty-nine coalitions (26.9%) involved the posterior facets only (subtype-P), 74 coalitions (68.5%) involved both the middle and posterior facets (subtype-MP), and five coalitions (4.6%) simultaneously involved the anterior, middle, and posterior facets (subtype-AMP). Type II-MP coalition was the most common.Conclusion A new classification system of the talocalcaneal coalition to facilitate operative planning was developed.
Lag Between COVID-19 Cases And Subsequent Deaths
Authors: Donovan Sara , Brett-Major David , Lawler James V. 
Published: May 2021

Abstract
Background: Observed COVID-19 cases and deaths are frequently used as independent factors to justify the use or de-escalation of non-pharmaceutical interventions. To investigate and describe the temporal relationship between changes in epidemic curves for COVID-19 cases and deaths, a longitudinal analysis of these metrics was performed for 16 states in the United States and three countries.Results: The analysis performed demonstrates a considerable, consistent lag between a surge in COVID-19 cases and the subsequent rise in attributable deaths, with approximately a month-long lag observed.Conclusions: The time lag identified must be incorporated in health emergency decision making in order to avoid the pre-mature de-escalation of disease mitigation measures.
WITHDRAWN: Role of Growth Factors &amp; Neurophysiological Markers In Evaluation of Neuroplasticity Using 1Hz rTMS With Physical Therapy In Ischemic Stroke: A Double Blind, Parallel Group, Sham Controlled Randomized Trial
Authors: Sharma Hina , Kumar Nand , Vishnubhatla Sreenivas , MR Rajeswari , Srivast M.V. Padma 
Published: May 2021

Abstract
Background: The therapeutic benefits of repetitive trans cranial magnetic stimulation along with physical therapy to study the neuroplasticity and neurogenesis in ischemic stroke patients has not been fully elucidated. The aim of this study is to determine the neuroplasticity using serum growth factors as a surrogate marker, using 1Hz rTMS with conventional physiotherapy in patients with sub acute ischemic stroke.Methods: In this study, participants with first ever ischemic stroke (N = 96), onset within 15 days were randomized after a run-in period of 75 ± 7 days along with standard physical therapy to receive 10 sessions of real 1Hz rTMS (N = 47) on contralesional premotor cortex or to sham stimulation (N = 49) for 2 weeks. Participants, investigators and outcome assessors were blinded. The primary efficacy outcome was change in the level of peripheral serum growth factors VEGF & BDNF at third month. The secondary outcome was measurement of neurophysiological parameters and their correlation with growth factors levels.Results: Modified intention to treat analysis showed significant up regulation in the mean level of serum VEGF & BDNF from pre to post rTMS in Real rTMS Group. Trend of decrease in Resting Motor Threshold and increase in Motor Evoked Potential in the affected hand was seen. Statistically significant negative correlation between motor evoked potential and mean VEGF (rho = -1.000, P<0.001) in the affected hand in Real rTMS Group was seen.Conclusion: Total ten sessions of 1Hz rTMS plus physical therapy on contralateral hemisphere resulted in up regulation of serum growth factors possible reflecting improved neuroplasticity. Trial funded by Indian Council of Medical Research (ICMR), India, CTRI/2016/02/006620. Retrospectively registered. Note: As this is not a regulatory trial, therefore under Indian regulatory authorities, ICMR, any trial registered before 1st April 2018 was registered as retrospective study. Ethics committee approval for this study was taken in 2012.
Comparison Between Healthcare Professionals And The General Population On Parameters Related To Natural Remedies Used During The COVID-19 Pandemic
Authors: Alotiby Amna Abdullah , Alshareef Maram Hashim 
Published: May 2021

Abstract
Introduction: Herbal medicine is a common method for symptom relief and treatment because of its ample availability and lack of regulation on its prescription. However, herbal use is associated with adverse effects, drug interaction, and sometimes life-threatening complications. During the coronavirus disease (COVID-19) pandemic, people shifted toward herbs when modern medical field failed to discover a treatment or immunization early in the course of the disease. Based on expert consensus, herbal medicine was recommended in Eastern countries, although trials were still ongoing. Methods: A descriptive web-based anonymous survey was created and distributed online all-over Saudi Arabia to gather information on commonly used herbs, knowledge, and attitude towards them among general population (GP) and health care workers (HCWs).Results: Although natural product use was high among GPs, both groups used similar herbs, reflecting cultural tradition and beliefs. However, GPs show better knowledge and attitude about herbal medicine than HCWs. Conclusion: Mental exhaustion during the COVID-19 pandemic and a lack of medicine-based evidence might influence HCW’s trust and knowledge on herbal medicine. Therefore, research and educational courses on herbal medicine for all medical practitioners are needed for proper counseling, thereby reducing risk and ensuring patient safety.
Characterization Of Microstructure And Selected Properties of SnSbCu Alloy After FSP
Authors: Hrabia-Wiśnios Joanna , Leszczyńska-Madej Beata , Madej Marcin , Węglowska Aleksandra 
Published: May 2021

Abstract
The paper presents the results of research on the microstructure and selected mechanical properties of the SnSbCu bearing alloy after friction stir processing (FSP). The Whorl tool was used for modification; the process was carried out using two rotational speeds of the tool: 280 and 450 RPM and a constant linear speed of 355 mm/min. Microstructure studies were performed employing the techniques of light microscopy and scanning electron microscopy along with analysis of the chemical composition of micro-areas. Additionally, the phase composition was investigated by means of the X-ray diffraction method and statistical analysis of the precipitates present in the investigated alloy. In addition, hardness, flexural strength and uniaxial compression tests were performed before and after FSP modification. It was proved that using FSP to modify the SnSbCu alloy promotes refinement and homogenization of the microstructure, as well as improvement of the flexural strength, whereas no changes in the hardness level were found.
Analytical, FEA, And Experimental Research of 2D-Vibration Assisted Cutting ( 2D-VAC) In Titanium Alloy Ti6Al4V
Authors: Kurniawan Rendi , Ahmed Farooq , Park Gun Chul , Ko Tae Jo 
Published: May 2021

Abstract
In the 2D-Vibration Assisted Cutting (2D-VAC) method, the cutting tool shakes in a 2-dimensional approach because of superimposed high-frequency modulation. This high-frequency modulation effect creates a displacement at a tiny scale of micrometers and causes an escalation in the resultant cutting speed. Consequently, 2D-VAC has superior advantages compared to traditional cutting (TC). This manuscript describes research on 2D-VAC that focuses on modeling cutting forces (mathematical model) and finite element analysis (FEA) results. The FEA results are focused on the von Mises stress, plastic strain, cutting force, cutting temperature, and residual stress. In addition, an experiment for the chip formation, micro-structure layer, and micro-hardness was also analyzed in this study. According to the modeling results, the cutting force has a comparable pattern to the FEA results. The stress contour result confirms that the 2D-VAC method has lower stress than that in the TC method during tool retraction mode. Additionally, the plastic strain in the 2D-VAC method can be higher than that in the TC method. According to the temperature results, the peak temperature in the 2D-VAC could be higher than that in the TC method. The residual stress shows that there is a compressive effect. Thus, the compressive stress is higher than that in the TC method. Micro-hardness results confirmed that there is not too much change from the original surface in the 2D-VAC method. The result of micro-structure morphology also confirmed that there is a significant shear deformation flow in case of the TC method, although less occurs in the 2D-VAC method.
Application and Validation of a Biotic Ligand Model for Calculating Acute Toxicity of Lead to Moina Dubia in Lakes of Hanoi, Vietnam
Authors: Pham Hong Thi , Vu Long Duc , Le Ngoc Chi , Hoang Thu-Huong Thi 
Published: May 2021

Abstract
It is increasingly being recognized that biotic ligand models (BLMs) are valuable in the risk assessment of metals in aquatic systems. The authors investigated the effect of pH, Ca, Mg, K, Na on the acute toxicity of Pb to Moina dubia, native zooplankton in lakes of Hanoi, Vietnam. Calcium, Magnesium and pH strongly influenced acute Pb toxicity to Moina dubia. Based on this data set, a acute Pb-BLM for Moina dubia was developed according to condition of Hanoi lakes. The developed BLM was shown, in an independent validation with data on acute toxicity test on natural water sets, to be capable of predicting chronic Pb toxicity with 81.3% accuracy. The results proved that BLM can be useful tool for calculating the acute toxicity based on water-quality criteria in lake of Hanoi.
Prediction of Hemodynamic Tolerance of Intermittent Hemodialysis in Critically Ill Patients: A Cohort Study
Authors: Passos Rogerio da Hora , Caldas Juliana , Ramos Joao Gabriel , de Melo Erica , Silveira Marcelo Augusto Duarte , Batista Paulo Benigno 
Published: May 2021

Abstract
Background: The evaluation and management of fluid balance are key challenges when caring for critically ill patients requiring renal replacement therapy (RRT). The aim of this study was to assess the ability of clinical judgment and other variables to predict the occurrence of hypotension during intermittent hemodialysis (IHD) in critically ill patients.Methods: This was a prospective, observational, single-center study involving critically ill patients undergoing IHD. The clinical judgment of hypervolemia was determined by the managing nephrologists and critical care physicians in charge of the patients on the basis of the clinical data used to calculate the ultrafiltration volume and rate for each dialysis treatment.Results: Seventy-nine (31.9%) patients presented with hypotension during IHD. Patients were perceived as being hypervolemic in 109 (43.9%) of the cases by nephrologists and in 107 (43.1%) by intensivists. The agreement between nephrologists and intensivists was weak (kappa =0.561). Receiver operating characteristic (ROC) curve analysis yielded an AUC of 0.81 (95% CI 0.75 to 0.84; P < 0.0001), and a cutoff value of 70 mm for the vascular pedicle width (VPW) had the highest accuracy for the prediction of the absence of hypotension.Conclusions: The clinical judgment of hypervolemia did not predict hypotension during IHD. The high predictive ability of the VPW may assist clinicians with critical thinking.
Evaluation of Online Medical Education During COVID-19 Pandemic in Shanghai：A Prospective Study
Authors: Song Yaxiang , Wang Shu , Liu Yixian , Liu Xinying , Peng Ai 
Published: May 2021

Abstract
Background: The global popularity of COVID-19 has led China’s universities to conduct online teaching. However, the real feedback from medical teachers and students regarding online education is unclear. The purpose of this study was to investigate the characteristics and effectiveness of online teaching among teachers and students in Medical School of Tongji University during the COVID-19 pandemic. Methods: A prospective survey was conducted to investigate the current status on online education among teachers and students in Medical School of Tongji University. Results: 1) 488 valid questionnaires were collected from 223 males (45.7%) and 265 females (54.3%), including 394 students (80.7%) and 94 teachers (19.3%). 2) Although students thought that too much learning tasks were assigned in the mode of online teaching, most of teachers and students endorse this teaching mode. 3) Male students had better performance than female students in online class. 4) Compared with male teachers, female teachers had less experience on online educational course recording and teaching training. They had more difficulty in adapting to online education. There was no significant difference in the acceptance of online teaching among teachers in different age groups Conclusions: 1) Most teachers and students supported and satisfied with the implement of online education during the epidemic pandemic. Although teachers were less adaptable to online education than students, they still had the positive opinions. 2) Gender influenced the acceptance of online teaching. Male teachers and students showed better adaptability than female counterpart. 3) Though online teaching had advantages, it still cannot completely replace traditional offline teaching.
The Predictive Role of Platelet-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index in Young and Middle-Aged Patients with Tibial Plateau Fractures
Authors: Song Qingcheng , Hu Hongzhi , Deng Xiangtian , Xing Xin , Chen Wei , Zhang Yingze 
Published: May 2021

Abstract
Background

There is suggestive evidence that the platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are related to the severity of fracture. The purpose of this study was to investigate the role of PLR and SII in predicting fracture severity in young and middle-aged patients with tibial plateau fractures (TPFs).
Methods

The retrospective cohort study involving 229 isolated TPFs was performed between January 2015 and December 2019. Medical records of hospitalized patients were extracted from the electronic case system. Three experienced orthopedic surgeons classified the imaging data according to the Schatzker classification. All the patients were divided into two groups: group1 consisted of fractures of mild to moderate severity (Schatzker types I-IV), and group2 consisted of fractures of severe severity (Schatzker types V-VI). Platelet, neutrophil, and lymphocyte values at admission were obtained. The PLR = platelet/lymphocyte counts and the SII = platelet × neutrophil/lymphocyte counts were noted. Patients in groups 1 and 2 were statistically compared in terms of PLR and SII value on hospital admission.
Results

There were significant differences in the blood PLR, SII, Na+ and K+ levels, and neutrophil count between the two groups. According to the receiver operating characteristic (ROC) curve, the cut-off of PLR and SII were 157.9 and 923.9, respectively. Our results showed that high PLR and SII were remarkably associated with the severity of TPFs. The sensitivity was 60% and the specificity was 86.9% when using the PLR ≥ 157.9 to predict the severity of the TPFs whereas the sensitivity was 63.3% and the specificity was 74.4% to predict the severity of TPFs at SII ≥ 923.9. In the multivariate analyses, the high preoperative PLR and SII were identified as independent predictors of severe TPFs.
Conclusions

The PLR and SII are simple and economical biomarkers that can be calculated from routine blood tests and can be used to predict the severity of tibial plateau fractures.
Intranasal Delivery of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Alleviates Memory Deficits In Sporadic Alzheimer’s Rat Models By Regulating Neurotrophic and Apoptotic Genes
Authors: Eslami Ebrahim , Hour Farshid Qiyami , Sadr Marjan , Ajdary Marziyeh , Shabani Ronak , Mehdizadeh Mehdi 
Published: May 2021

Abstract
Alzheimer's disease (AD) is the most common cause of dementia in adulthood, followed by cognitive and behavioral deficits. Today, mesenchymal stem cell (MSC)-based therapy is a suitable therapeutic option to improve regenerative medicine approaches against neurodegenerative disorders, including AD. This study aimed to investigate the effects of human Wharton’s jelly-derived MSCs (WJ-MSCs) on Alzheimer's rat models by evaluating the expression of neurotrophic factors involved in neurodegenerative diseases, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), as well as the expression of apoptotic factors, such as B-cell lymphoma 2 (BCL2, an apoptosis inhibitor), BCL2-associated X protein (BAX, an apoptosis initiator), and caspase 3 (an apoptosis executioner). The AD rat modeling was performed by intrahippocampal injection of 8 µg/kg of amyloid β1-42 (Aβ1-42). The animals were divided into three groups of eight rats each: I) control; II) AD model; and III) MSC-treated model. Behavioral tests (i.e., passive avoidance and Morris water maze tests) showed cognitive improvements. Also, amelioration of cells in the CA1 area of the hippocampus was detected by cresyl violet (Nissl) staining. Besides, real-time polymerase chain reaction (RT-PCR) of the hippocampus indicated an increase in BDNF and NGF genes and a decrease in apoptosis-related genes (BCL2, BAX, and caspase 3). Overall, the WJ-MSCs improved the cognitive function in AD rat models by increasing neurotrophic factors and decreasing apoptotic factors.
WITHDRAWN: Discovery of Potential Compounds Against SARS-COV-2 Based on 3clpro/Rdrp Dual-Target an in Silico Approach
Authors: Li Jiaojiao , Zhu Lin , Qin Zheng , Li Zhengfu , Gao Xun , Shen Jinyang 
Published: May 2021

Abstract
Currently, Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) lacks clinically specific drugs. In this study, the new coronavirus SARS-CoV-2 3-chymotrypsin-like protease(3CLpro)and RNA-dependent RNA polymerase(RdRp)were used as targets for virtual screening. After analysis of molecular docking and molecular dynamics simulation results, ZINC04259665,ZINC12659533 and ZINC70705490 have good docking scores,and they are stable in combination with 3CLpro/RdRp. The prediction of drug-like properties found that ZINC04259665 has good druggability and has the potential to further explore its anti-SARS-CoV-2.
The Effects of Hydrogen-Rich Water on Skin Wound Healing in Dogs
Authors: Qi Dong-Dong , Wang Ting , Hayat Muhammad Abid , Liu Tao , Zhang JianTao 
Published: May 2021

Abstract
Background: Hydrogen-rich water (HRW) has been shown to be one of underlying therapeutic strategies regarding wound treatments. This study explored the effects of drinking HRW on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The experimental group was treated with HRW twice daily, while the control group was provided with distilled water (DW). The wound tissues of dogs examined histopathologically. The fibroblasts, inflammatory cell infiltration, the average number of new blood vessels, and the level of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in the skin homogenate of the wound was measured using the corresponding kits. The expression of Nrf-2, HO-1, NQO-1, VEGF, and PDGF were measured by real-time fluorescence quantitative method. Results: We observed that HRW wound had significant average healing rate and faster average healing time. Histopathological results showed that the average number of blood vessels and the average thickness of epidermis were significantly different from the DW group. The MDA levels were higher in the DW group than in the HRW group but the SOD levels were higher in the HRW group than in the DW group. The results of qRT-PCR showed that the expression of each gene was significantly different between the two groups. Conclusions: The results showed that HRW treatment could promote skin wound healing in dogs, accelerate wound epithelization, reduce inflammatory reaction, stimulate the expression of cytokines related to wound healing, and shorten wound healing time.