bluuebunny/crossref_metadata_2025_split huggingface dataset:
To Study the Efficacy of Low Level Laser Therapy as Compared to Patellofemoral Mobilization along with Knee Strengthening Exercises (Conventional treatment) in Patients with Bilateral Patellofemoral Knee Osteoarthritis- A Randomised Split- Body Design.
Authors: Goyal Hanisha 
Published: October 2021

Purpose: The main purpose of the study was to find out the effects of Low Level Laser Therapy in patients presenting with diagnosis of bilateral patellofemoral knee osteoarthritis. The objective of our research is: To improve functional outcome.
Methodology: A split-body-experimental design was done by random sampling for 4 weeks. A minimum of 20 subjects (i.e., 40 knees) were assigned for the study and low level laser therapy was applied to the right 20 knee (experimental group) and left 20 knee (control group) received conventional treatment in bilateral osteoarthritis, therefore number of knees tested were 20 for low level laser therapy and other 20 will receive conventional treatment
Result: Statistically significant improvement was indicated in respect to all parameters taken in WOMAC scale such as pain, stiffness and physical function. There was also significant decrease in swelling by both conventional and additional low level laser therapy. Improvements in all parameters of the experimental group were more statistically significant when compared to parameters of control group (p <0.05).
Conclusion: This study suggests that there is significant improvement with additional Low Level Laser therapy as well as with conventional treatment in patients with patellofemoral knee osteoarthritis but there is more significant improvement in experimental group in which Low level laser therapy was given along with exercise program. There is decrease in pain, swelling and stiffness. Hence, addition of Low Level laser therapy in patella-femoral knee osteoarthritis is more effective than conventional treatment.
Keywords: Patellofemoral osteoarthritis, Low Level laser therapy, knee joint, isometric strengthening.
Implementasi Belajar Dari Rumah dan Kesiapan Pembelajaran Tatap Muka di Madrasah
Authors: Taufik Opik Abdurrahman , Basri Husen Hasan , Sumarni Sumarni 
Published: October 2021

AbstractDuring the pandemic, the government issued the policy to learning from home, followed by the other policy to open face-to-face learning in the New Normal era. This study aims to determine the implementation of learning from home policy and the readiness of madrasas to conduct face-to-face learning in the New Normal era. This research was conducted using an online survey method in 2021. The results showed that 85% of madrasas carried out the learning process online, of which 86.8% were carried out through the assignment method from the teacher. In the learning process at home, only 28.7% of students were accompanied, reminded, supervised, and assisted by their parents. It means that the role of parents in learning from home is minimal. However, 86.5% provide internet access. Regarding the readiness of madrasas in face-to-face learning, 62.24% were not ready to carry out face-to-face learning. This unreadiness relates to the difficulties in fulfillment of aspects that are required for face-to-face learning.AbstrakPada masa pandemi, pemerintah mengeluarkan kebijakan belajar dari rumah, lalu disusul dengan kebijakan untuk membuka pembelajaran tatap muka di era New normal. Penelitian ini bertujuan untuk mengetahui implementasi kebijakan belajar dari rumah dan kesiapan madrasah untuk melakukan pembelajaran tatap muka di era New normal. Penelitian ini dilakukan dengan metode survei dalam jaringan (daring) pada tahun 2021. Hasil penelitian menunjukkan bahwa sebanyak 85,0% madrasah melakukan proses pembelajaran dalam bentuk daring, di mana 86,8% dilakukan melalui metode penugasan dari guru. Dalam proses pembelajaran di rumah, hanya 28,7% siswa yang didampingi, diingatkan, diawasi, dan dibantu oleh orang tuanya. Hal ini mengindikasikan peran orang tua dalam pembelajaran dari rumah terlihat minim. Namun demikian sebesar 86,5% menyediakan akses internet. Terkait dengan kesiapan madrasah dalam pembelajaran tatap muka, dari 2040 madrasah yang disurvei sebesar 62,2% tidak siap melaksanakan pembelajaran tatap muka). Ketidaksiapan tersebut berkaitan dengan pemenuhan aspek yang menjadi syarat pembelajaran tatap muka.
PENINGKATAN KETERAMPILAN BERBICARA MELALUI METODE BERCERITA PADA SISWA KELAS III SDK LEI
Authors: Lega Maria Dolorosa 
Published: October 2021

<p><span lang="EN-US">Penelitian ini bertujuan untuk meningkatkan keterampilan berbicara siswa dan membantu siswa kelas III SDK LEI. Penelitian ini menggunakan metode bercerita. Jenis penelitian ini adalah penelitian tindakan kelas yang dilaksanakan dalam 2 siklus, yang terdiri atas Kegiatan Awal, Kegiatan Inti dan kegiatan akhir. Data yang diperoleh dalam penelitian ini meliputi hasil belajar siswa yang diambil dari pemberian tes bercerita di depan kelas, kemampuan guru dalam pengelolaan pembelajaran yang diambil dari lembar observasi kegiatan guru, aktivitas siswa yang diambil dari lembar observasi kegiatan siswa. Hasil penelitian menunjukkan bahwa pada tindakan siklus I terdapat presentase ketuntasan klasikal 60% dan daya serap individu sebesar 64,28% sedangkan hasil observasi aktivitas siswa 62,5% dan observasi aktivitas guru 87,5% dengan kategori cukup. Pada tindakan siklus II terdapat 22 siswa yang tuntas secara invidu sehingga presentase ketuntasan klasikal 88% dan daya serap individu 79,94% sedangkan hasil observasi aktivitas siswa 87,5% dan hasil observasi guru 85,7% dengan kategori sangat baik. Hal ini berarti pembelajaran pada siklus II telah memenuhi indikator keberhasilan sehingga dapat disimpulkan bahwa perbaikan pembelajaran dengan menggunakan metode Bercerita dapat meningkatkan keterampilan berbicara siswa pada mata pelajaran bahasa Indonesia di kelas III SDK LEI.</span></p>
PENERAPAN MODEL PEMBELAJARAN BERBASIS PROYEK UNTUK MENINGKATKAN PRESTASI BELAJAR PESERTA DIDIK PADA MATA PELAJARAN PRODUK KREATIF DAN KEWIRAUSAHAAN KELAS XII BC SMK NEGERI 2 KOTA BOGOR
Authors: Hermawati Neneng 
Published: October 2021

Penelitian ini bertujuan (1) untuk mengetahui model pembelajaran Berbasis Proyek dapat meningkatkan aktivitas dan hasil belajar peserta didik tentang materi Produk Teknologi Tepat Guna, (2) untuk menggambarkan proses peningkatan aktivitas dan hasil belajar peserta didik tentang materi Produk Teknologi Tepat Guna sebelum dan sesudah menggunakan model pembelajaran Berbasis Proyek, (3) untuk mengukur besarnya peningkatan hasil belajar peserta didik tentang materi Produk Teknologi Tepat Guna setelah menggunakan model pembelajaran Berbasis Proyek. Hasil penelitian ini menunjukkan bahwa dengan menggunakan model pembelajaran Berbasis Proyek dapat menjadi variasi pembelajaran yang menyenangkan bagi peserta didik sehingga terbukti meningkatkan aktivitas dan hasil belajar peserta didik di Kelas XII BC SMK Negeri 2 Kota Bogor. Sebelum menggunakan model pembelajaran Berbasis Projek <em> </em>hasil belajar peserta didik hanya memiliki nilai rata-rata 74.14. Siklus pertama meningkat dengan nilai rata-rata sebesar 78.00, meningkat lagi di siklus ke-dua dengan perolehan nilai atau hasil belajar peserta didik dengan nilai rata-rata sebesar 81.70, dan di siklus ke-tiga nilai rata-rata peserta didik meningkat lagi menjadi 86.10. Aktivitas peserta didik dalam pembuatan produk teknologi tepat guna. Perolehan prosentase pada siklus pertama sebesar 53,45% (cukup aktif), perolehan prosentase pada siklus ke-dua sebesar 78.62% (aktif), dan perolehan prosentase pada siklus ke-tiga sbesar 95.52% (sangat aktif).<strong> </strong>Maka dapat disimpulkan terjadi peningkatan aktivitas peserta didik diantara ketiga siklus tersebut. Sehingga penggunaan model pembelajaran Berbasis Proyek yang disesuaikan dengan materi pembelajaran dapat menciptakan situasi belajar yang menyenangkan sehingga terjadi peningkatan aktivitas dan hasil belajar peserta didik.
Intalasi Komputer Dan Penggunaan E-Info Pada SMA N 1 Kefamenanu
Authors: Berek Claria Fransiska Agatha , Manek Siprianus Septian 
Published: October 2021

Teknologi informasi dan komunikasi saat ini telah berkembang sangat pesat di masyarakat, terutama di kalangan para pelajar. Akan tetapi masih banyak yang belum bisa memanfaatkan Teknologi informasi dan komunikasi dengan baik seperti masalah yang terjadi pada SMA N 1 Kefamenanu. Pemanfaatan Teknologi informasi dan komunikasi pada sekolah tersebut belum maksimal dikarenakan sarana dan prasarana pada laboratorium komputer yang ada pada SMA N 1 Kefamenanu masih ada beberapa komputer yang rusak maupun belum terinstall sistem operasi. Dari permasalah di atas, maka dilakukan kegiatan pengabdian dengan judul Instalasi Komputer Dan Penggunaan E-Info Pada SMA N 1 Kefamenanu. Hasil kegiatan pengabdian kepada masyarakat ini yaitu: penggunaan laboratorium komputer menjadi lebih maksimal dan dengan pengenalan pemanfaatan e-info pada siswa , sehingga siswa dapat menerapkan pengunaan teknologi informasi dan komunikasi pada proses belajar mengajar di SMA N 1 Kefamenanu.
Relationship between mood state and cardiac autonomic modulation in jiu-jitsu fighters in the pre- and post-competitive period: A pilot study
Authors: Nascimento-Carvalho Bruno , Izaias João Eduardo , Jesus Ney Roberto de , Dos Santos Adriano , Nascimento Thália Leticia Brito , Ruaro Marcio Flavio , Scapini Katia Bilhar , Sanches Iris Callado 
Published: October 2021

Aim: To characterize the changes in body composition, mood state and cardiac autonomic modulation in Brazilian Jiu-Jitsu (BJJ) of athletes in the pre- and post-competitive periods. Methods: Eight male athletes were evaluated in 3 moments: 14 days and 1 day before the fight, and 2 days after the competition. Evaluations of body composition, mood state, and cardiac autonomic modulation were performed. The repeated measures Anova test, Pearson and Spearman correlation were used for data analysis (p < 0.05). Results: We observed reductions in anger (6.80 ± 1.69 vs. 4.20 ± 1.67 vs. 3.40 ± 1.07) and tension (6.60 ± 0.81 vs. 5.40 ± 0.75 vs. 2.60 ± 0.88) after competition. Vigor was reduced one day before the competition and remained the same two days after the competition (12.80 ± 1.60 vs. 10.00 ± 1.95 vs. 10.40 ± 1.03). In addition, there was an increase in sympathetic modulation (LF-PI: 2942 ± 655.3 vs. 5479 ± 2035 vs. 5334 ± 2418 abs). There was a positive correlation between the state of vigor and sympathetic modulation (r = 0.55), a negative correlation between the states of depression and sympathetic modulation (r = -0.68) and confusion and sympathetic modulation (r = -0.67). Conclusion: These findings raised concerns about the preparation of these athletes for competitions since changes in the state of vigor might reduce performance and increase cardiovascular risk.
Development and Validation of Nomogram Models for Postoperative Pneumonia in Adult Patients Undergoing Elective Cardiac Surgery
Authors: Wang Dashuai , Chen Xing , Wu Jia , Le Sheng , Xie Fei , Li Ximei , Wang Hongfei , Huang Xiaofan , Zhang Anchen , Du Xinling 
Published: October 2021

Background: Postoperative pneumonia (POP) is a frequent complication following cardiac surgery, related to increased morbidity, mortality and healthcare costs. The objectives of this study were to investigate the risk factors associated with POP in adults undergoing elective cardiac surgery and to develop and validate nomogram models.Methods: We conducted a multicenter retrospective study in four cardiac centers in China. Adults operated with elective open-heart surgery from 2016 to 2020 were included. Patients were randomly allocated to training and validation sets by 7:3 ratio. Demographics, comorbidities, laboratory data, surgical factors, and postoperative outcomes were collected and analyzed. Risk factors for POP were identified by univariate and multivariate analysis. Nomograms were constructed based on the multivariate logistic regression models and were evaluated with calibration, discrimination and decision curve analysis.Results: A total of 13,380 patients meeting the criteria were included and POP developed in 882 patients (6.6%). The mortality was 2.0%, but it increased significantly in patients with POP (25.1 vs. 0.4%, P &lt; 0.001). Using preoperative and intraoperative variables, we constructed a full nomogram model based on ten independent risk factors and a preoperative nomogram model based on eight preoperative factors. Both nomograms demonstrated good calibration, discrimination, and were well validated. The decision curves indicated significant clinical usefulness. Finally, four risk intervals were defined for better clinical application.Conclusions: We developed and validated two nomogram models for POP following elective cardiac surgery using preoperative and intraoperative factors, which may be helpful for individualized risk evaluation and prevention decisions.
A New Clinical Model to Estimate the Pre-Test Probability of Cushing’s Syndrome: The Cushing Score
Authors: Parasiliti-Caprino Mirko , Bioletto Fabio , Frigerio Tommaso , D’Angelo Valentina , Ceccato Filippo , Ferraù Francesco , Ferrigno Rosario , Minnetti Marianna , Scaroni Carla , Cannavò Salvatore , Pivonello Rosario , Isidori Andrea , Broglio Fabio , Giordano Roberta , Spinello Maurizio , Grottoli Silvia , Arvat Emanuela 
Published: October 2021

BackgroundHypercortisolism accounts for relevant morbidity and mortality and is often a diagnostic challenge for clinicians. A prompt diagnosis is necessary to treat Cushing’s syndrome as early as possible.ObjectiveThe aim of this study was to develop and validate a clinical model for the estimation of pre-test probability of hypercortisolism in an at-risk population.DesignWe conducted a retrospective multicenter case-control study, involving five Italian referral centers for Endocrinology (Turin, Messina, Naples, Padua and Rome). One hundred and fifty patients affected by Cushing’s syndrome and 300 patients in which hypercortisolism was excluded were enrolled. All patients were evaluated, according to current guidelines, for the suspicion of hypercortisolism.ResultsThe Cushing score was built by multivariable logistic regression, considering all main features associated with a clinical suspicion of hypercortisolism as possible predictors. A stepwise backward selection algorithm was used (final model AUC=0.873), then an internal validation was performed through ten-fold cross-validation. Final estimation of the model performance showed an average AUC=0.841, thus reassuring about a small overfitting effect. The retrieved score was structured on a 17.5-point scale: low-risk class (score value: ≤5.5, probability of disease=0.8%); intermediate-low-risk class (score value: 6-8.5, probability of disease=2.7%); intermediate-high-risk class (score value: 9-11.5, probability of disease=18.5%) and finally, high-risk class (score value: ≥12, probability of disease=72.5%).ConclusionsWe developed and internally validated a simple tool to determine pre-test probability of hypercortisolism, the Cushing score, that showed a remarkable predictive power for the discrimination between subjects with and without a final diagnosis of Cushing’s syndrome.
Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids
Authors: Feng Xunxun , Zhai Guangyao , Yang Jiaqi , Liu Yang , Zhou Yujie , Guo Qianyun 
Published: October 2021

BackgroundAs metabolic molecules, bile acids (BAs) not only promote the absorption of fat-soluble nutrients, but they also regulate many metabolic processes, including the homeostasis of glucose and lipids. Although total serum BA (TBA) measurement is a readily available clinical test related to coronary artery disease (CAD), myocardial infarction (MI), and type 2 diabetes mellitus (T2DM), the relationship between TBA and these pathological conditions remain unclear, and research on this topic is inconclusive.MethodsThis study enrolled 20,255 menopausal women aged over 50 years, including 6,421 T2DM patients. The study population was divided into different groups according to the median TBA level in order to explore the clinical characteristics of menopausal women with different TBA levels. Spline analyses, generalized additive model (GAM) model and regression analyses based on TBA level were used to explore the relationship between TBA and different diseases independently, including CAD and MI, or in combination with T2DM.ResultsBoth in the general population and in the T2DM subgroup, the TBA level was significantly lower in CAD patients than in non-CAD patients. Spline analyses indicated that within normal clinical range of TBA concentration (0–10 µmol/L), the presence of CAD and MI showed similar trends in total and T2DM population. Similarly, the GAM model indicated that within the 0–10 μmol/L clinical range, the predicted probability for CAD and MI alone and in combination with T2DM was negatively correlated with TBA concentration. Multivariate regression analysis suggested that low TBA level was positively associated with the occurrence of CAD combined with T2DM (OR: 1.451; 95%CI: 1.141–1.847).ConclusionsIn menopausal women, TBA may represent a valuable clinical serum marker with negative correlation for CAD and MI in patients with T2DM.
The Risk of Postpartum Hemorrhage Following Prior Prelabor Cesarean Delivery Stratified by Abnormal Placentation: A Multicenter Historical Cohort Study
Authors: Shilei Bi , Lizi Zhang , Yulian Li , Yingyu Liang , Lijun Huang , Minshan Huang , Baoying Huang , Jinping Jia , Yinli Cao , Shaoshuai Wang , Xiaoyan Xu , Ling Feng , Yangyu Zhao , Xianlan Zhao , Qiying Zhu , Hongbo Qi , Suiwen Wen , Lanzhen Zhang , Hongtian Li , Jingsi Chen , Zhijian Wang , Lili Du , Dunjin Chen 
Published: October 2021

Background: Prior prelabor cesarean delivery (CD) was associated with an increase in the risk of placenta previa (PP) in a second delivery, whether it may impact postpartum hemorrhage (PPH) independent of abnormal placentation. This study aimed to assess the risk of PPH stratified by abnormal placentation following a first CD before the onset of labor (prelabor) or intrapartum CD.Methods: This multicenter, historical cohort study involved singleton, pregnant women at 28 weeks of gestation or greater with a CD history between January 2017 and December 2017 in 11 public tertiary hospitals within 7 provinces of China. PPH was analyzed in the subsequent pregnancy between women with prior prelabor CD and women with intrapartum CD. Furthermore, PPH was analyzed in pregnant women stratified by complications with PP alone [without placenta accreta spectrum (PAS) disorders], complications with PP and PAS, complications with PAS alone (without PP), and normal placentation. We performed multivariate logistic regression to calculate adjusted odds ratios (aOR) and 95% CI controlling for predefined covariates.Results: Out of 10,833 pregnant women, 1,197 (11%) women had a history of intrapartum CD and 9,636 (89%) women had a history of prelabor CD. Prior prelabor CD increased the risk of PP (aOR 1.91, 95% CI 1.40–2.60), PAS (aOR 1.68, 95% CI 1.11–2.24), and PPH (aOR 1.33, 95% CI 1.02–1.75) in a subsequent pregnancy. After stratification by complications with PP alone, PP and PAS, PAS alone, and normal placentation, prior prelabor CD only increased the risk of PPH (aOR 3.34, 95% CI 1.35–8.23) in a subsequent pregnancy complicated with PP and PAS.Conclusion: Compared to intrapartum CD, prior prelabor CD increased the risk of PPH in a subsequent pregnancy only when complicated by PP and PAS.
Identification of Novel Modalities Through Bibliometric Analysis for Timely Development of Regulatory Guidance: A Case Study of T Cell Immunity
Authors: Fukaya-Shiba Ai , Otsuka Kouhei , Sasaki Hajime , Shikano Mayumi , Wakao Rika 
Published: October 2021

Background: The mission of medicines regulatory agencies is to ensure the timely access of innovative products for patients to improve public health. Thus, regulators should foresee evolving technologies and build expertise prior to reviewing innovative products. Novel modalities and new classes of therapeutics in biological or cell-based products represent a regulatory challenge because of knowledge gaps, as exemplified by the unexpected cytokine release syndrome in the first-in-human clinical trial of the CD28 super-agonist. Meanwhile, recent treatments harnessing T cell co-signaling pathways provide an opportunity for investigation. Therefore, this study aimed to systematically identify and evaluate novel modalities for T cell immunity to assess the need for regulatory guidance.Methods: A PubMed search was carried out using the query, “immun* AND t lymph*” to select publications. Subsequently, a citation network was created, followed by clustering and text mining to identify the modalities and classes of therapeutics under development.Results and Discussion: Analysis of the top 20 clusters revealed research domains characterized by keywords such as immune checkpoint antibody, chimeric antigen receptor (CAR)-T cells, microbiota, exosome, regulatory T cells, unconventional T cells, and vaccines. After reviewing the pharmacological concepts, clinical trial information, and available guidance, we presented a perspective on the future development of guidance for these domains.Conclusion: Bibliometric analyses identified a set of innovative modalities targeted for drug development with which regulatory guidance is going to catch up. This strategy could help in the successful development of upcoming modalities to ensure readiness for clinical application as part of horizon scanning.