bluuebunny/crossref_metadata_2025_split huggingface dataset:
A preliminary comparison of mastery criterion frequency values: Effects on acquisition and maintenance
Authors: Schneider Anna , Fienup Daniel M. , Gussin Rosaria , Moss Patricia 
Published: October 2021

AbstractHigher levels of performance during skill acquisition predict higher levels of response maintenance, but less is known about how many observations of high levels of performance are needed to produce this effect of criterion levels. We analyzed two criterion‐level frequency values, or the number of observations of criterion‐level performance. We taught children with disabilities target skills to 90% accuracy observed one time or across three consecutive sessions/days. Participants required fewer sessions to meet the terminal acquisition‐performance criterion when the frequency value was set to one and response maintenance outcomes were comparable between conditions. These outcomes suggest that the frequency component of acquisition‐performance criterion is related to the efficiency of skill acquisition for participants with comparable repertoires.
Targeting metabolic driving and minimization of by‐products synthesis for high‐yield production of D‐pantothenate in Escherichia coli
Authors: Li Bo , Zhang Bo , Wang Pei , Cai Xue , Tang Ya‐Qun , Jin Jie‐Yi , Liang Jin‐Xi , Liu Zhi‐Qiang , Zheng Yu‐Guo 
Published: October 2021

AbstractBackgroundd‐Pantothenate (DPA) is an important functional chemical that has been widely applied in healthcare, cosmetics, animal food, and feed industries.Methods and ResultsIn this study, a high‐yield DPA‐producing strain was constructed by metabolic engineering strategies with targeting metabolic driving and by‐products minimization. The metabolic driving force of push and pull was firstly obtained to improve the production of DPA via enrichment of precursor pool and synthetic pathway, accumulating 4.29 g L−1 DPA in shake flask fermentation. To eliminate the metabolic pressure on DPA production, an amino throttling system was proposed and successfully attenuated the synthesis of four competitive amino acids by a single‐step regulation of gdhA. Further minimization of acetate was carried out by pta deletion, and utilization of β‐alanine was improved via enhancing its uptake system with producing 5.78 g L−1 DPA. Finally, the engineered strain produced 66.39 g L−1 DPA with β‐alanine addition in fermentor under fed‐batch fermentation.ConclusionThis study paved a foundation for the industrial production of DPA.
RETRACTED: The impact of sustainable development strategy on sustainable supply chain firm performance in the digital transformation era
Authors: Nayal Kirti , Raut Rakesh D. , Yadav Vinay Surendra , Priyadarshinee Pragati , Narkhede Balkrishna E. 
Published: October 2021

AbstractAvailability of limited resources presents the need for sustainable development strategies to achieve sustainable performance. However, in the era of digitalization and globalization many researchers explored the role of digital technologies in improving sustainable performance. However, the literature on the role of collaboration and coordination in a digitally enabled supply chain (SC) to achieve sustainability is still lacking. This study aims to investigate the effect of supply chain collaboration and coordination (SCC), sustainable development strategy (SDS), digital transformation (DIT), and collaborative advantages (COA) on sustainable supply chain firm performance (SSCFP). The conceptual model is based on the relational view (RV), transaction cost economics (TCE), technology, organization and environment (TOE), and resource‐based view (RBV) theories. This study utilizes structural equation modeling (SEM) to analyze data collected from 361 respondents of the automotive industry in India. The findings show that SCC positively affects SDS and DIT. SDS positively affects DIT, COA, and DIT positively affects SSCFP. DIT fully mediates the relationship between SCC and COA. The study suggests that managers can apply SCC, SDS, and DIT in series to achieve sustainable performance. However, the COA can only be enhanced in the digitalized SC. The study provides empirical evidence to policymakers and practitioners for the synergy between SCC, SDS, DIT, and COA to achieve sustainable performance in the SC's manufacturing firm.
Online lessons of human anatomy: Experiences during the COVID‐19 pandemic
Authors: Zarcone Daniela , Saverino Daniele 
Published: October 2021

AbstractThe social distancing measures necessitated by the COVID‐19 pandemic have resulted in the migration of human anatomy lessons to virtual platforms. Even student communities have had to relocate online. The virtual replacement of visual–spatial and social elements, essential for studying anatomy, has posed particular challenges for educators. Our department used Microsoft Teams, an online communication platform, in conjunction with Visible Body, a 3D anatomical modeling program, EdiErmes online resources, and Leica Acquire for teaching microscopic anatomy. We delivered about 160 h of both synchronous and asynchronous lessons for students on the medical degree program per academic year. In this study, we compare face‐to‐face and distance teaching in order to define these different approaches better and to evaluate the final student scores. The aim is to debate the relevance of distance learning pedagogy to the design of new online anatomy teaching courses and the development of online learning. Analysis of the final scores showed that anatomy examinations after the online course had a statistically significantly higher average value than those obtained at the end of the face‐to‐face course. The experience at the University of Genoa shows that distance learning in the teaching of human anatomy was perceived by most students as useful and positive. Distance learning can be an effective support for anatomy teaching, facilitating a different mode of learning in which lessons and study are more sensitive to the individual's schedule and needs. Of course, we should not and cannot exclude face‐to‐face teaching.
Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
Authors: Guo Chengcheng , Mi Jianqiang , Li Haike , Su Panke , Nie He 
Published: October 2021

AbstractIntroductionCircular RNAs (circRNAs) play critical roles in tumorigenesis, but their clinical efficacy in esophageal squamous cell carcinoma (ESCC) still retains controversial. This meta‐analysis aims at evaluating the associations between circRNA expressions and clinicopathologic features as well as the diagnostic and prognostic values of circRNAs in ESCC.Materials & MethodsPubMed, EMBASE, and other online databases were systematically searched to collect studies on circRNAs and clinicopathological features, diagnostic, and/or prognostic assessments of ESCC. The quality of included studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS‐2) and Newcastle‐Ottawa Scale (NOS) scales. The included studies were quantitatively weighted and merged, and diagnostic indicators, hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were calculated. P values were merged by Fisher᾽s method. Sources of heterogeneity were traced using subgroup, sensitivity, and meta‐regression analyses.ResultsAs a result, 12 studies were included, representing 769 ESCC patients. The meta‐analysis showed that abnormal expressions of circRNAs were associated to TNM stage as well as lymph node and distant metastases in ESCC cases. CircRNA was used to distinguish ESCC patients from healthy controls, and the merged sensitivity, specificity, and the area under the curve (AUC) of ESCC were 0.78 (95% CI: 0.74–0.81), 0.79 (95% CI: 0.75–0.83), and 0.86, respectively. The survival analysis showed that upregulated oncogenic circRNA levels in ESCC tissues was associated with the shorter overall survival (OS) of the patients (univariate analysis: HR = 2.25, 95% CI: 1.71–2.95, p = 0.000, I2 = 0.0%; multivariate analysis: HR = 2.50, 95% CI: 1.61–3.89, p = 0.000, I2 = 0.0%), while the OS of ESCC patients presenting overexpressions of tumor‐suppressive circRNAs was significantly ameliorated (HR = 0.29, 95% CI: 0.20–0.42, p = 0.000, I2 = 0.0%). The subgroup analyses based on circRNA biofunctions, sample size, and reference gene also revealed robust results.ConclusionCircRNAs can be used as promising molecular biomarkers for the early diagnosis and prognosis monitoring of ESCC.
‘You don't take things too seriously or un‐seriously’: Beyond recovery to liminal and liminoid possibility in a community arts and mental health project
Authors: Laver Cassie , McGrath Laura , Liebert Rachel Jane , Noorani Tehseen , Barnes Nick , Chase Mike , Hall Jon , Wakeling Ben 
Published: October 2021

AbstractRecent years have seen a renewed interest in integrating creative activities into statutory mental health practice in high‐income countries. In this article, we offer an exploratory analysis of an arts project delivered within UK mental health services, Creativity for Enablement and Wellbeing (CREW). Drawing on data collected for a process evaluation of the project, we suggest that conceptualising CREW as liminal and liminoid provides a helpful way to articulate the processes, atmospheres, relationships, and practices of the project. Through this theoretical lens, we identify CREW as a mode of engagement comprising looseness, possibility and collectivity, all brought together through a unique community event, the showcase. We explore CREW's mode of engagement through three themes: ‘carving out a liminal space’, ‘looseness and experimentation,’ and ‘from liminal to liminoid’. Implications for service delivery are discussed, focussing on how CREW managed to create a transformative space of liminoid possibility rather than a recovery journey delineated by service‐defined imperatives.
Anti‐Inflammatory Properties of Longifuran A, a New Benzofuran from the Stems of Amomum longiligulare
Authors: Thanh Huong Le , Anh Thu Pham , Thi Dao Phi , Thi Mai Huong Doan , Van Cuong Pham , Hai Dang Nguyen 
Published: October 2021

AbstractIn this study, the following compounds were isolated from the dichloromethane fraction of the stems of Amomum longiligulare and then characterized: a new benzofuran, namely, longifuran A (1); five other phenolic compounds, namely, 4‐methoxycinnamic acid (2), 2,5‐dimethoxyphenol (3), eudesmic acid (4), 1,7‐bis(4‐hydroxyphenyl)‐1,4,6‐heptatrien‐3‐one (5), and 4,4’‐dihydroxychalcone (6); and two triterpenoids, namely, 24‐methylcycloartan‐3β‐ol (7) and 24‐methylencycloartan‐3β‐ol (8). They were evaluated in terms of their inhibitory effects on NO production in LPS‐stimulated RAW 264.7 macrophages. Results indicated that 1 and 5 exhibited promising inhibitory activities against NO generation with IC50 of 10.47±1.02 μM and 8.51±1.14 μM, respectively. Enzymatic assays demonstrated that they remarkably suppressed the secretion of two pro‐inflammatory cytokines (i. e., IL‐6 and TNF‐α). They also dose‐dependently inhibited the expression of inducible nitric oxide synthase and cyclooxygenase‐2, two important enzymes modulating inflammation. Therefore, 1 and 5 could be targets for the development of new anti‐inflammatory therapeutics
Recent Advances in Isolation, Synthesis and Biological Evaluation of Terrein
Authors: Huang Dan , Yang Jianni , Li Chen , Hui Yang , Chen Wenhao 
Published: October 2021

AbstractTerrein is a small‐molecule polyketide compound with a simple structure mainly isolated from fungi. Since its discovery in 1935, many scholars have conducted a series of research on its structure identification, isolation source, production increase, synthesis and biological activity. Studies have shown that terrein has a variety of biological activities, not only can inhibit melanin production and epidermal hyperplasia, but also has anti‐cancer, anti‐inflammatory, anti‐angiopoietic secretion, antibacterial, insecticidal activities, and so on. It has potential application prospects in beauty, medicine, agriculture and other fields. This article reviews the process of structural identification of terrein since 1935, and summarizes the latest advances in its isolation, source, production increase, synthesis, and biological activity evaluation, with a view to providing a reference and helping for the in‐depth research of terrein.
Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications
Authors: Sułkowska‐Ziaja Katarzyna , Balik Monika , Muszyńska Bożena 
Published: October 2021

AbstractThis study presents the current knowledge on chemical composition, biological activity, and possible medicinal applications of Phellinus igniarius, Phellinus pini, Phellinus pomaceus, and Phellinus robustus. These inedible arboreal species are phytopathogens that cause the enzymatic decomposition of wood. These species belong to the medicinal mushrooms and have been known for centuries in the traditional medicine of the Far East. They have been used as an effective remedy for stomach and intestinal ailments, diarrhea, and hemorrhages. Mycochemical studies have proved the presence of polysaccharides, phenolic compounds, and terpenoids. These compounds show biological activities such as anticancer, antioxidant, antiangiogenic, and antiviral. Research studies conducted using modern analytical methods have advanced the knowledge on the potential therapeutic use of compounds isolated not only from the fruiting bodies but also from biomass obtained with in vitro biotechnological methods.
Three Dimensional Macroporous Oxygen‐Deficient TiO2‐x Supported N, P, Co‐tridoped Carbon as Efficient Oxygen Reduction Electrocatalyst
Authors: Yu Hang , Zhao Ximeng , Wu Feichao , Luo Yuhong , Jia Aizhong , Wang Yanji , Li Jingde 
Published: October 2021

AbstractDeveloping efficient and durable electrocatalysts of oxygen reduction reaction (ORR) is critical for high‐performance air cathodes. Herein, a novel three‐dimensionally ordered macroporous oxygen‐deficient TiO2 framework embedded with N, P and Co‐tridoped carbon (3DOM Co/NPC@TiO2‐x) is elaborately designed for ORR. This unique structure offers a high surface area, good mass transfer, excellent electronic conductivity, and stability. Moreover, the experimental and theoretical studies reveal that the synergistic effect of N, P co‐doping and Co‐decoration is indispensable to promote the ORR performance, yielding high O2 adsorption energy and lowering the reaction barriers simultaneously. Accordingly, the ORR catalytic activity and stability of the proposed electrocatalyst are better than Pt/C in alkaline media. The resulting primary zinc‐air battery delivers a high open‐circuit voltage (1.50 V) and specific capacity (820 Wh kg−1) at 20 mA cm−2. This strategy, combining macroporous oxygen‐deficient oxide support with binary heteroatom doping, provides a new perspective for exploiting efficacious ORR electrocatalysts.
19F MRI Probes for Multimodal Imaging**
Authors: Janasik Dawid , Krawczyk Tomasz 
Published: October 2021

AbstractMagnetic resonance imaging (MRI) is one of the most powerful imaging tools today, capable of displaying superior soft‐tissue contrast. This review discusses developments in the field of 19F MRI multimodal probes in combination with optical fluorescence imaging (OFI), 1H MRI, chemical exchange saturation transfer (CEST) MRI, ultrasonography (USG), X‐ray computed tomography (CT), single photon emission tomography (SPECT), positron emission tomography (PET), and photoacoustic imaging (PAI). In each case, multimodal 19F MRI probes compensate for the deficiency of individual techniques and offer improved sensitivity or accuracy of detection over unimodal counterparts. Strategies for designing 19F MRI multimodal probes are described with respect to their structure, physicochemical properties, biocompatibility, and the quality of images.
The impact of the COVID‐19 pandemic on African American cancer survivors
Authors: Beebe‐Dimmer Jennifer L. , Lusk Christine M. , Ruterbusch Julie J. , Baird Tara E. , Pandolfi Stephanie S. , Wenzlaff Angela S. , Hastert Theresa A. , Harper Felicity W. K. , Thompson Hayley S. , Schwartz Ann G. 
Published: October 2021

BackgroundCoronavirus disease 2019 (COVID‐19) has had profound effects on population health to date. African American cancer survivors are particularly vulnerable to developing severe consequences; therefore, understanding the impact of the virus on this patient population is critical.MethodsThe Detroit Research on Cancer Survivors cohort is a unique effort to understand the determinants of poor outcomes in African American cancer survivors. To date, more than 4500 cancer survivors and nearly 950 primary caregivers have been enrolled; participation includes a survey and the collection of biospecimens, medical records, and tumor tissue. Beginning in the spring of 2020, a supplemental survey focusing on the impact of COVID‐19 was offered to enrolled participants. The analysis included 890 survivors.ResultsNearly all survivors (>99%) reported changes in their daily activities in an effort to reduce the risk of infection. More than 40% of the survivors reported some disruption in their access to medical care. A substantial proportion of the survivors (>40%) reported feeling anxious, depressed, and/or isolated during the COVID‐19 pandemic. Approximately 40% of the patients reported changes in health behaviors shown to negatively affect survivorship outcomes (physical inactivity, smoking, and alcohol use) as a result of the pandemic.ConclusionsThe influence of the COVID‐19 pandemic on African American cancer survivors is substantial: it has affected both their physical and mental health. Coupled with changes in health behaviors, these factors will likely affect outcomes in this high‐risk patient population, and this makes further study and interventions necessary to mitigate the long‐term impact of the pandemic on cancer outcomes.
Decontamination of multispecies oral biofilm from rough implant surface by airflow with glycine
Authors: Leung Kyla , Bi Jiarui , Giannelis Georgios , Owen Gethin , Larjava Hannu 
Published: October 2021

AbstractObjectivesDecontamination of biofilm‐colonized rough implant surfaces remains challenging. We investigated the effect of airflow with glycine powder (AFG) on decontamination of mature oral multispecies biofilm from a sandblasted and acid etched (SLA) titanium surface.Materials and MethodsSubgingival dental plaque was cultured on SLA disks anaerobically for 21 days. AFG with various settings and distances was applied directly on the disks with or without previous rinse of 0.9% NaCl. The specimens were then analyzed through scanning electron microscope and remaining bacteria on the implant surface were quantified and statistically compared.ResultsMature oral biofilm with cocci and rods as major morphotypes, as well as spiral‐ and filamentous‐shaped organisms, was formed on the untreated disks. Saline rinsing removed the thick biofilm layer but left numerous of coccoid bacteria in rough surface pits. AFG effectively removed most of the bacteria from the pits. Both 25% and 50% power settings were equally effective at 3‐mm distance. With 50% power, AFG successfully removed bacteria at both 3‐ and 6‐mm distance. When AFG was applied on native biofilm without prior rinsing with saline, it effectively removed the biofilm including bacteria in the pits.ConclusionApplication of AFG appears effective in removing bacteria from rough implant surfaces.
Defining distribution and habitat use of west‐central Florida’s coastal sharks through a research and education program
Authors: Mullins Lindsay L. , Drymon J. Marcus , Moore Moriah , Skarke Adam , Moore Alan , Rodgers John C. 
Published: October 2021

AbstractIdentifying critical habitat for highly mobile species such as sharks is difficult, but essential for effective management and conservation. In regions where baseline data are lacking, non‐traditional data sources have the potential to increase observational capacity for species distribution and habitat studies. In this study, a research and education organization conducted a 5‐year (2013–2018) survey of shark populations in the coastal waters of west‐central Florida, an area where a diverse shark assemblage has been observed but no formal population analyses have been conducted. The objectives of this study were to use boosted regression tree (BRT) modeling to quantify environmental factors impacting the distribution of the shark assemblage, create species distribution maps from the model outputs, and identify spatially explicit hot spots of high shark abundance. A total of 1036 sharks were captured, encompassing eleven species. Abundance hot spots for four species and for immature sharks (collectively) were most often located in areas designated as “No Internal Combustion Engine” zones and seagrass bottom cover, suggesting these environments may be fostering more diverse and abundant populations. The BRT models were fitted for immature sharks and five species where n > 100: the nurse shark (Ginglymostoma cirratum), blacktip shark (Carcharhinus limbatus), blacknose shark (C. acronotus), Atlantic sharpnose shark (Rhizoprionodon terraenovae), and bonnethead (Sphyrna tiburo). Capture data were paired with environmental variables: depth (m), sea surface temperature (°C), surface, middle, and bottom salinity (psu), dissolved oxygen (mg/L), and bottom type (seagrass, artificial reef, or sand). Depth, temperature, and bottom type were most frequently identified as predictors with the greatest marginal effect on shark distribution, underscoring the importance of nearshore seagrass and barrier island habitats to the shark assemblage in this region. This approach demonstrates the potential contribution of unconventional science to effective management and conservation of coastal sharks.
Feral hogs control brackish marsh plant communities over time
Authors: Hensel Marc J. S. , Silliman Brian R. , Hensel Enie , Byrnes Jarrett E. K. 
Published: October 2021

AbstractFeral hogs modify ecosystems by consuming native species and altering habitat structure. These invasions can generate fundamentally different post‐invasion habitats when disturbance changes community structure, ecosystem function, or recovery dynamics. Here, we use multiple three‐year exclusion experiments to describe how feral hogs affect hyper‐productive brackish marshes over time. We find that infrequent yet consistent hog foraging and trampling suppresses dominant plants by generating a perpetually disturbed habitat that favors competitively inferior species and disallows full vegetative recovery over time. Along borders between plant monocultures, trampling destroys dominant graminoids responsible for most aboveground marsh biomass while competitively inferior plants increase fivefold. Hog activities shift the brackish marsh disturbance regime from pulse to press, which changes the plant community: competitively inferior plants increase coverage, species diversity is doubled, and live cover is lowered by 30% as large plants are unable to take hold in hog‐disturbed areas. Release from disturbance does not result in complete recovery (i.e., dominant plant monocultures) because hog consumer control is a combination of both top‐down control and broader engineering effects. These results highlight how habitats are susceptible to invasive effects outside of structural destruction alone, especially if large consumers are pervasive over time and change the dynamics that sustain recovery.