bluuebunny/crossref_metadata_2025_split huggingface dataset:
The investigation of IL-1β and oxytocin levels among teenager with primary dysmenorrhea
Authors: Mukhoirotin  , Kurniawati  , Fatmawati Diah Ayu 
Published: July 2021

Abstract
Primary dysmenorrhea is one of gynecological problems and it commonly occurred among adolescents and reproductive age women during menstruation with some complaints such as pain, cramps and back pain. In primary dysmenorrhea there is an increase of PGF2α levels, vasopressin (VAP), Oxytocin (OT), IL-6 and IL-1β level. The aim of this study was assessed the differences of IL-1β levels and oxytocin among adolescents with primary dysmenorrhea and without primary dysmenorrhea. The research design in this study used Case Control. The population of this study were all students of Health Science Faculty, Unipdu Jombang. The sample of this study was 16 respondents, and they were divided into 2 groups: the case group (n = 8) and the control group (n = 8) that met the inclusion and exclusion criteria. Sampling method used Purposive Sampling technique. The measurement of IL-1β and Oxytocin levels used ELISA method. The data were analyzed by using Independent Sample T-Test with α ≤ 0.05. The results of this study showed that an average level of IL-1β in case group was 23.830 pg/ml, in control group was 14.715 pg/ml; the average OT levels in case group was 384.662 pg/ml, the control group was 353.262 pg/ml. Independent Sample T-Test showed that there was a significant differences of IL-1β and oxytocin level between case group and control group (p<0.05). IL-1β and Oxytocin (OT) Levels among adolescents with primary dysmenorrhea were higher than adolescents who menstruate without primary dysmenorrhea.
The Effects of Pineapple Extract Toothpaste (Ananas comosus L.Merr) on Saliva Flow Rate
Authors: Minarni  , Susi  , Murniwati  
Published: July 2021

Abstract
Women in the menopause period experience biological changes, decreased production of the hormones estrogen and progesterone resulting in xerostomia (dry mouth). Dry mouth treatment can be carried out using mechanical and chemical stimuli. Citric acid stimulation is one way to increase the flow rate of saliva. Pineapple contains a high amount of citric acid. The purpose of this study is to determine the effect of toothpaste with pineapple extract, which increasing salivary flow rate in women in menopause period at the Integrated Health Center (Posyandu) for elderly in Baso Health Center. This type of experimental research using pretest-posttest control group design and the sample selection was taken by simple random sampling with a lottery technique. The number of samples was 32 people who were divided into two groups, namely the treatment group and the control group. Saliva was collected before and after treatment into the saliva pot for 5 minutes using the spitting method. Data analysis using paired T test and unpaired T test. The results showed that there was an increase in salivary flow rate with the use of pineapple extract toothpaste 50% of 1.651 ml/minute and with fluoride toothpaste. 1,170 ml/minute. There is an effect of brushing teeth with pineapple extract toothpaste on the salivary flow rate with a significance value of p = 0.000 <0.05. Pineapple extract toothpaste can be used as an alternative treatment for xerostomia for women in menopause period.
Vegetation structure and species composition of habitat types Goniothalamus macrophyllus (Blume) Hook.f. and Thomson in Lowland Forest, Kuningan Regency, West Java
Authors: Adhya Ilham , Hendrayana Yayan , Supartono Toto , Ismail Agus Yadi , Nurdin  
Published: July 2021

Abstract
Goniothalamus macrophyllus is a forest product that grows in lowland forests and has the potential as a medicinal plant that has not been fully utilized. The purpose of this study was to determine the vegetation structure and species composition in the area where Goniothalamus macrophyllus grows naturally. Determination of the research location using purposive sampling method. Furthermore, the sampling method in this study was encounter -sampling. in the lowland forests of Kuningan Regency, West Java. Goniothalamus macrophyllus was found at an altitude of 432 - 1,273 m above sea level, with a stand composition of 108 species of seedling plants, 125 species of saplings, 98 species of poles and 105 species of trees. The highest dominance at seedling level is Coffea spp, sapling level is Decapermum paniculatum, pole level is Villebrunea rubenscens, and tree level is Villebrunea rubenscens.
Siam Madu citrus seeding in supporting the development of Sumatra citrus zone
Authors: Marpaung Imelda S , Sembiring Perdinanta , Girsang Moral A , Purba Tommy 
Published: July 2021

Abstract
The purposes of this study were to identify the potency of citrus farming and to recommend citrus seeding development policy in North Sumatra Province. The method used in this study was desk study, and secondary data was analyzing descriptively. Citrus seeding is one of the keys to the success of citrus farming. North Sumatra Province is one of the centers for citrus development in Indonesia. The seed is one of the keys to the success of farming. Currently, citrus development in North Sumatra is still constrained by the availability of seeds. Only a few proportions of the seeds that are currently used by farmers were from local breeders and usually carried out if there was a government program. The shortage of citrus seeds came from outside of North Sumatra Province as the Bangkinang citrus variety which is parent stock source was not guaranteed. One of the citrus types in North Sumatra Province is called ‘siam madu’ citrus. The opportunity for siam madu citrus seeding development was feasible, considering that siam madu citrus was very popular for citrus farmers.
Characterization of GABA (gamma-aminobutyric acid) levels some fermented food in Indonesia
Authors: Herawati Heny , Afifah Diana Nur , Kusumanigtyas Eni , Usmiati Sri , Soemantri Agus S. , Miskiyah  , Kamsiati Elmi , Bachtiar Muchamad 
Published: July 2021

Abstract
Indonesia has a huge wealth of local fermented products. These local food products have the potential to be developed into functional food that has added value and can contribute to public health in order to prevent disease. GABA (gamma-aminobutyric acid) is a prospective amino acid component that is widely found in fermented products from local food. GABA is alleged to have the functional capacity to build the immune system, improve the respiratory system, benefit diabetics, improve brain performance, prevent cancer and tumors and other health effects. The purpose of this research activity is to characterize the levels of GABA in several commercial fermented foods in Indonesia. The methodology used in this research is to identify and characterize commercial fermented food and to analyze the proximate levels and levels of GABA contained therein. The analysis was carried out using the spectrophotometric method. Based on the analysis results, several commercial fermented foods in Indonesia contain varying levels of GABA. The increased use of MSG increases the GABA levels to a certain level. This research deserves to be further researched and developed in relation to the optimization of the extraction process and the implementation of the use of other additives to increase GABA levels.
In silico development of new candidate of NADPH oxidase inhibitor for hypertension treatment
Authors: Laksono Agung Budi , Kusumawati Ratna , Suselo Yuliana Heri , Indarto Dono 
Published: July 2021

Abstract
Hypertension is a silent killer that becomes the important risk factor for stroke and ischemic heart disease. Oxidative stress which results from high production of reactive oxygen species (ROS) in the endothelial layer, contributes to hypertension pathophysiology. The high activity of NADPH oxidase is the main ROS source. Many medicinal plants have been developed to treat some human diseases. This study aimed to explore virtually Indonesian phytochemicals as a NADPH oxidase inhibitor for hypertension treatment. This bioinformatics study used a molecular docking method with P47-phox protein and apocynin as protein target and standard ligand respectively, which were obtained from Protein Data Bank and ZINC databases with 1NG2 and 0162515 codes. Indonesian phytochemicals were obtained from the HerbalIBD, had molecular structure from the PubChem database, and met the Lipinski’s criteria. The AutoDock Vina version 1.1.2 was used to analyse the binding affinity and sites and the PyMol 1.3 program was for visualization of molecular docking results. Apocynin interacted with P47-phox with -5.5 kcal/mol binding score and binding at Asp221, Arg302, Arg316 residues to prevent NADPH activation. Compared to apocynin, morindone had lower binding score (-7.7 kcal/mol) to bind to P47-phox and had similar binding sites at Arg 302, Arg 316, and Arg 318 residues. In conclusion, morindone potentially becomes a NADPH oxidase inhibitor in silico for hypertension treatment.
Iron supplement for anemia developed from home industry waste of snake fruit Pondoh (Snake fruit edulis Reinw.)
Authors: Natasia K , Indarto D , Wasita B , Melati D , Ristanti I K 
Published: July 2021

Abstract
Anemia due to iron deficiency in young girls and pregnant women remains a nutritional health problem in Indonesia. They take iron tablet/day to improve their iron status but it sometimes has some side effects. In Sleman Regency, snake fruits Pondoh are used to make various processed foods but some home food industries leave snake fruit seeds as industrial waste. Therefore, the aim of this study was to extract gradually seeds of snake fruits Pondoh for development of anemia iron supplement. In this explorative study, we collected seeds of snake fruits Pondoh from a home food industry in Turi district, Sleman Regency, Yogyakarta. In brief, we made simplicia of snake fruit seeds in several steps from washing, selecting, drying, cutting in small pieces, grinding to separating with 100 mesh sieve. After that, the simplicia was extracted using tetrahydrofuran, methanol, acetic acid, hexane and or ethyl acetate reagents to separate lipid, water and organic fractions, which were then dried using a vacuum evaporator. Dried fractions of snake fruit seeds (SFS) were finally measured using the inductively coupled plasma or atomic absorption spectroscopy method for iron levels and using ferric chloride for tannin content. From two different methods of making simplicial, we got 26.88 and 22.82% (weigh/weight) iron levels while ethyl acetate SFS fraction had higher iron levels (2.65% w/v) than lipid and water fractions (1.62 and 1.88% respectively). In addition, there was only the water fraction that contained tannin. In conclusion, the ethyl acetate fraction of SFS Pondoh may be useful for development of anemia iron supplement.
Variations in the incubation time of the Staphylococcus aureus, Bacillus sp and Escherichia coli cultures on the results of the gram stain visualization
Authors: Prayekti Endah , Sumarsono Thomas 
Published: July 2021

Abstract
Gram staining is a routine procedure performed in microbiology laboratories. Gram staining of bacteria was used to obtain data on the shape and group of gram bacteria. The results of gram staining can give confusing results so that the next process will be invalid. Several things were found in the laboratory, pure culture staining that should show gram-positive, but the results showed gram-negative or the presence of a mixture of gram-positive and negative in one field of view. The aim of this study was to determine the effect of incubation time on the results of gram bacteria staining. This research is an experimental study using pure cultures of Staphylococcus aureus, Bacillus sp, and Escherichia coli at 16, 18, 20, 24, and 26 hours of culture. The parameter observed was the color that was shown after gram staining at each bacterial culture age. The data obtained is qualitative data which is then processed into quantitative and then statistically analyzed. Statistical results using kruskall walis showed a significant difference between treatment groups based on incubation time. The results of the most uniform gram staining visualization were found at the incubation time of 16 and 18 hours.
Innovation development information system for sales of traditional food processed product web based in the Cibinuang Village
Authors: Sugiharto Tito , Irwansyah Mohammad , Ajiziyah Sepphirotul , Heryanto Widi , Hidayat Syarif 
Published: July 2021

Abstract
This research aims to produce a web-based information system for the sale of traditional food products in Cibinuang Village. The research target to be achieved is the existence of a web-based sales information system that can be used to carry out promotional activities, sales and transactions. This information system for the sale of traditional food products was created to be implemented in Cibinuang Village to help people increase sales and increase their economic benefits. This research discusses how the process of designing, creating and developing an information system for the sale of traditional food products. The absence of an information system for the sale of traditional food products in Cibinuang Village is a serious problem that must be addressed. The people of Cibinuang Village find it difficult to increase sales of processed traditional food products during the Covid 19 pandemic. The methodology used in this research is the Rational Unified Process (RUP). The testing process is carried out using the Black Box Testing and the User Acceptance Test. Therefore, to solve this problem, we need an innovation in the sale of web-based traditional food products. It is hoped that the web-based information system for selling traditional food products in Cibinuang Village can help increase sales and the community’s economic benefits.
Forest Land Management System and Effect on The Presence Of Birds at Nusa Laut Island
Authors: Tjoa M , Latumahina Fransina 
Published: July 2021

Abstract
Management of forest land by the community is generally to meet the needs of life, but on the other hand forest land also provides benefits for birds as a habitat for various activities and for the survival of these birds. This study aimed to determine how the effect of forest land management systems by the community on the existence of birds. The research approach used was field surveys and interviews with land management communities. The results showed that the Ameth community land management system was divided into land use to make gardens indicated by types of food plants (vegetables and tubers) and use to make dusung indicated by longevity plant species (nutmeg, cloves, coconut, etc.). The community found 10 identified species of birds when managing land. Then, based on the result of the study, 26 species were found in a sample location of 5 hectares. Although the birds do not get the attention of the community, there are community anticipatory actions to anticipate the occurrence of conditions and efforts to protect the garden and dusung from damage to plants by birds.
Waste management model at Bugel Village – Kulonprogo District, Yogyakarta Special Province
Authors: Agung Nugroho Darojad N. , Dawam Muhammad 
Published: July 2021

AbstractVillage community have not been fully aware of the economic value of waste management. The knowledge limitation of waste management and the availability of waste management facilities to be the reason for not dealing with waste management, instead of throwing and piling up the waste. Waste economic potential, and at the same time the abundance of existing coconut waste is not manage well. The objective of the research to develop a model for economic reason for the household. The method applied qualitative research. The results found an economic model for household through a commercial (a home industry) through digital waste management and community-based participation through waste bank management. Recommendation from the model: There are three factors can be adapting to support the success of waste management through local wisdom responsibility, activities supervision, and the attractive activity. To the local manager development also need to socialize and internalize the important aspect on waste and waste utilization.
Framework to Manage Software Quality on IIoT Apps
Authors: Julio Yair Rivera , Contreras Bertha Hernández , Rivera Samir Castaño , López Clara Colón , Mangonez Angel Dario Pinto , Herazo Harold Bula 
Published: July 2021

Abstract
The research presents a Framework based on CMMI and ITIL methodology. It complemented with an ASQ management type, which allows incorporating metrics that directly involve both the development process of embedded systems based on IoT architectures and oriented to industry 4.0 or IIoT. The methodology is based on the development of software for Embedded Systems using SysML modeling. The scheme to allows incorporates necessary mechanisms that enable the management of the System related to service continuity and easy adaptation to changes, considering service connectivity and compatible with an industrial environment. This scheme allows quantifying through indicators each one of the quality levels, providing at the same time the practicality and the systematization of the processes, which in the end translates into a consistent mapping for the standardization of the quality related to the lines of business that imply the treatment of IoT data at industrial level. The methodology permits are simplifying the need to deal with rapid software changes, one of the essential tasks of software systems development and maintenance teams. Due to the lack of standards and regulated work schemes for the development of IoT architectures; therefore, it is intended to establish implicitly the metrics and an essential work scheme to regulate the design, progress, and development of IIoT architectures, until defining an optimal state of implementation.
Bi-objective routing model with speed variation and consideration of emissions: Case study of solid waste collection in Coveñas, Sucre
Authors: Ruiz-Meza J , Montoya-Torres J R , Mejía-Ayala D , Navaja S 
Published: July 2021

AbstractModels for routing vehicles have been applied to solve a variety of transport route design problems. Also, it has taken an important trend on environmental care in consideration of the negative environmental impact generated by the emissions resulting from transportation. Another relevant aspect of environment care is the collection of solid wastes due to the high quantities generated by human activities. In this paper, we developed a bi-objective model for routing vehicles for solid waste collection that considers the minimization of costs associated with both vehicles and CO2emissions. The model considers heterogeneous fleet, capacity, hard time windows, and speed variation in an urban center. A case study in the Caribbean region of Colombia is studied, with a total of 50 nodes in the network. Because of the computational hardness, nodes are clustered in five sets of 10 nodes to obtain optimal solutions. The sum of costs showed a reduction of 9.447% compared to current costs (50 nodes without clustering). Subsequently, we reviewed and restructured some constraints that allowed to soften the complexity of the model and obtain improved solutions with reduced current costs by 16.55%.
Mathematical modeling for collaborative planning of two-echelon in the pineapple supply chain: A case study in San Marcos, Colombia
Authors: Ruiz-Meza J , Cárdenas-Díaz Y , Royeth-Angulo M K , Mejía-Ayala D 
Published: July 2021

Abstract
In the fruits sector supply chains, several decisions must be made about logistics operations that directly affect their productivity and competitiveness. Therefore, it is necessary to work collaboratively so that all actors and echelons of the chain benefit equally in strategic, tactical, and operational decisions. In this paper, we developed a mixed-integer linear programming model for the collaborative planning of the pineapple supply chain. The model allows the articulation and planning of the production and distribution echelons, considering the production planning and the transportation process, to maximize profits and increase the efficiency of the sector. We applied the model to the pineapple supply chain in the municipality of San Marcos, Sucre, Colombia. We carried out a characterization of the current state of pineapple production and distribution. Then, the mathematical model was developed and finally, the model was evaluated by developing analysis scenarios to make efficient decisions. Optimal computational results were obtained in a 10.53% increase in utility in the pineapple supply chain.
Proposal for an automated greenhouse to optimize the growth of hydroponic vegetables with high nutritional content in the context of smart cities
Authors: Sánchez S A , Morales A D , Castillas J C , Martínez C A , Meza A Z 
Published: July 2021

Abstract
Hydroponics is a cultivation method that has been gaining ground for a long time worldwide, due to its high nutritional content, low water consumption, scalability and zero use of pesticides, in addition to the versatility that this technique has to be implemented in almost any space. This is why the Antonio José de Sucre University Corporation, taking advantage of the characteristics of this cultivation technique, proposed the construction of an automated hydroponic greenhouse that serves as a model in the sustainable generation of food from the cities, following the example of smart cities; Within the construction of this proposal, it was necessary to study the requirements for planting the vegetables under hydroponic conditions in order to establish the technology that should have been used in their automation, for which the basic chemical and climatological needs in production were identified. of plant organisms, selecting those critical factors that intervene in productivity, in order to establish the appropriate types of sensors and an action protocol that maintain the values of these variables in optimum, tending to obtain healthy fruits and vegetables and superior in taste and nutrition. As a result, the design of a metallic hydroponic farm was obtained, for the location of the vegetables, recyclable materials such as PVC pipes were used and for the automation of the farm a raspberry pi electronic card was used complemented with PH, conductivity, temperature and humidity sensors. and lighting with the aim of obtaining quality products.
Application of 316L stainless steel coating by Directed Energy Deposition process
Authors: Barragan G A , Mariani F , Coelho R T 
Published: July 2021

Abstract
The corrosion problem faces a challenge for components in different industries. This research project aims to produce AISI 316L coatings in AISI 1045 plates of steel through additive manufacturing (AM) using a laser powder-fed system Direct Energy Deposition (DED) method. The coatings produced will be characterized using microstructural techniques (SEM/EDX and laser confocal), as well as microhardness Vickers. The average hardness value of the coating surface was 220 HV. The use of DED process for the coat of AISI 1045 material with AISI 316L has been proved as an efficient and viable operation.