bluuebunny/crossref_metadata_2025_split huggingface dataset:
The characteristics, types of intervention, and outcomes of postoperative patients who required rapid response system intervention: a nationwide database analysis
Authors:   In-Hospital Emergency Study Group, Sento Yoshiki , Arai Masayasu , Yamamori Yuji , Fujiwara Shinsuke , Tamashiro Masahiro , Kawamoto Eiji , Naito Takaki , Atagi Kazuaki , Fujitani Shigeki , Osaga Satoshi , Sobue Kazuya 
Published: February 2021

AbstractPurposeImproving the safety of general wards is a key to reducing serious adverse events in the postoperative period. We investigated the characteristics, treatment, and outcomes of postoperative patients managed by a rapid response system (RRS) in Japan to improve postoperative management.MethodsThis retrospective study analyzed cases requiring RRS intervention that were included in the In-Hospital Emergency Registry in Japan. We analyzed data reported by 34 Japanese hospitals between January 2014 and March 2018, mainly focusing on postoperative patients for whom the RRS was activated within 7 days of surgery. Non-postoperative patients, for whom the RRS was activated in all other settings, were used for comparison as necessary.ResultsThere were 609 (12.7%) postoperative patients among the total patients in the registry. The major criteria were staff concerns (30.2%) and low oxygen saturation (29.7%). Hypotension, tachycardia, and inability to contact physicians were observed as triggers significantly more frequently in postoperative patients when compared with non-postoperative patients. Among RRS activations within 7 days of surgery, 68.9% of activations occurred within postoperative day 3. The ordering of tests (46.8%) and fluid bolus (34.6%) were major interventions that were performed significantly more frequently in postoperative patients when compared with non-postoperative patients. The rate of RRS activations resulting in ICU care was 32.8%. The mortality rate at 1 month was 16.2%.ConclusionApproximately, 70% of the RRS activations occurred within postoperative day 3. Circulatory problems were a more frequent cause of RRS activation in the postoperative group than in the non-postoperative group.
“Corporate Digital Responsibility”
Authors: Herden Christina J. , Alliu Ervin , Cakici André , Cormier Thibaut , Deguelle Catherine , Gambhir Sahil , Griffiths Caleb , Gupta Shrishti , Kamani Sahil R. , Kiratli Yonca-Selda , Kispataki Máté , Lange Greta , Moles de Matos Leandro , Tripero Moreno Laura , Betancourt Nunez Hector Alain , Pilla Venkata , Raj Bairesh , Roe James , Skoda Markus , Song Youye , Ummadi Praveen Kumar , Edinger-Schons Laura Marie 
Published: February 2021

AbstractDigitalization is leading to profound changes in our private and work lives. New technologies are pervasive and create opportunities for new business models and lifestyles. Recently, the term “Corporate Digital Responsibility” has been coined to summarize the emerging responsibilities of corporations relating to their digitalization-related impacts, risks, challenges, and opportunities. The paper at hand reviews the topic of CDR using a multi-step approach. First, results from an opinion poll of 509 US-based respondents are reported which illustrate the perceived opportunities and threats associated with the topic of digitalization, underlining the need for a strategic approach to CDR implementation. Second, existing uses and definitions of the CDR terminology are summarized and a definition of CDR is derived. Third, twenty important topics related to CDR are identified, summarized and categorized into three categories using the ESG (Environmental, Social, Governance) framework. Finally, results are discussed with regards to their theoretical and managerial contributions and a hands-on guide which companies can use to implement a suitable CDR strategy is presented.
Possible changes in spatial distribution of walnut (Juglans regia L.) in Europe under warming climate
Authors: Paź-Dyderska Sonia , Jagodziński Andrzej M. , Dyderski Marcin K. 
Published: February 2021

AbstractJuglans regia L. is a species of great importance for environmental management due to attractive wood and nutritious fruits, but also high invasive potential. Thus, uncertainties connected with its range shift are essential for environmental management. We aimed to predict the future climatic optimum of J. regia in Europe under changing climate, to assess the most important climatic factors that determine its potential distribution, and to compare the results obtained among three different global circulation models (GCMs). We used distribution data from the Global Biodiversity Information Facility and completed it with data from the literature. Using the MaxEnt algorithm, we prepared a species distribution model for the years 2061–2080 using 19 bioclimatic variables. We applied three emission scenarios, expressed by representative concentration pathways (RCPs): RCP2.6, RCP4.5, and RCP8.5 and three GCMs: HadGEM2-ES, IPSL-CM5A-LR, and MPI-SM-LR. Our study predicted northward shift of the species, with simultaneous distribution loss at the southern edge of the current range, driven by increasing climate seasonality. Temperature seasonality and temperature annual range were the predictors of highest importance. General trends are common for the projections presented, but the variability of our projections among the GCMs or RCPs applied (predicted range will contract from 17.4 to 84.6% of the current distribution area) shows that caution should be maintained while managing J. regia populations. Adaptive measures should focus on maintaining genetic resources and assisted migration at the southern range edge, due to range contraction. Simultaneously, at the northern edge of the range, J. regia turns into an invasive species, which may need risk assessments and control of unintended spread.
Analyzing the effect of silvicultural management on the trade-off between stand structural heterogeneity and productivity over time
Authors: Zeller Laura , Caicoya Astor Toraño , Pretzsch Hans 
Published: February 2021

AbstractThis study combined an empirically based simulation with an analysis of the trade-off between structural heterogeneity and stand productivity depending on time, spatial scale, and silvicultural management, whereas volume growth and tree species diversity have been examined in detail, the role of forest structure and its interdependencies with stand productivity has only lately become a stronger research focus. We used the growth simulator SILVA to examine the development of stand structural heterogeneity and its trade-off with stand productivity in age-class versus uneven-aged pure and mixed spruce and beech stands at different spatial scales over 100 years. Those stands were based on typical forest types in Bavaria and were representative of forests in Central Europe. We examined how stand structure and its trade-off with productivity were modified by a multifunctional, a production-oriented, and a set-aside management scenario. The production-oriented management scenario applied to uneven-aged stands led to a reduction in structural heterogeneity per unit of productivity over time. In age-class stands, the production-oriented scenario was able to maintain the initial structural heterogeneity. The structural heterogeneity per unit of productivity increased more strongly with increasing spatial scale in age-class stands compared to uneven-aged stands. Combining forest stand simulation with scenario analyses is an exemplary method for testing the effect of silvicultural management alternatives on forest structure. This approach can later be connected to climate models considering long-term changes in growing conditions and support the planning of multifunctional forests.
Incorporating Polygenic Risk Scores in the ACE Twin Model to Estimate A–C Covariance
Authors: Dolan Conor V. , Huijskens Roel C. A. , Minică Camelia C. , Neale Michael C. , Boomsma Dorret I. 
Published: February 2021

AbstractThe assumption in the twin model that genotypic and environmental variables are uncorrelated is primarily made to ensure parameter identification, not because researchers necessarily think that these variables are uncorrelated. Although the biasing effects of such correlations are well understood, a method to estimate these parameters in the twin model would be useful. Here we explore the possibility of relaxing this assumption by adding polygenic scores to the (univariate) twin model. We demonstrate that this extension renders the additive genetic (A)—common environmental (C) covariance (σAC) identified. We study the statistical power to reject σAC = 0 in the ACE model and present the results of simulations.
Too Good To Be True: Influencing Credibility Perceptions with Signaling Reference Explicitness and Assurance Depth
Authors: Baier Carolin , Göttsche Max , Hellmann Andreas , Schiemann Frank 
Published: February 2021

AbstractWe investigate how the selection of assurance topics and the format of their communication influence the credibility perception of sustainability report readers. This is important because misleading communication may discredit ethical sustainability assurance practices. Based on signaling theory and using an experimental approach, we are the first to examine false credibility signals in the context of sustainability assurance. We find that two variables related to sustainability assurance, reference explicitness and assurance depth, jointly influence the assurance signal and the perceived credibility of a sustainability report. Our findings indicate that readers are not at risk of false signaling but can make incorrect interpretations of the assurance signal and might respond negatively to well-intentioned signals. The main implications of our findings are that firms should refrain from increasing reference explicitness and should select only the most material topics. Taken together, our results provide new insights on the unethical practice of false signaling and provide an example of an incorrect signal interpretation by readers.
An ultra-dispersive, nonprecious metal MOF–FeZn catalyst with good oxygen reduction activity and favorable stability in acid
Authors: Zhao Qing , Wang Cheng , Wang Haifeng , Wang Jianlong 
Published: February 2021

AbstractDevelopment of the more stable nonprecious oxygen reduction reaction (ORR) catalyst is of great significance nowadays. Herein, a high-performance iron-doped integral uniform macrocyclic organic framework (MOF–FeZn) catalyst is synthesized through a combined hydrothermal and pyrolysis process, showing favorable ORR activity and stability in acid. This as-synthesized MOF–FeZn catalyst displays high porous and graphitic structures with sufficient catalytic active dopants of pyridinic N, Fe–N, pyrrolic N, graphitic N, making it a promising ORR candidate catalyst with high electrochemical stability. The onset potential, half-wave potential and limited diffusion current density of MOF–FeZn are 0.93 V @ 0.1 mA cm−2, 0.768 V@ 2.757 mA cm−2 and 5.5 mA cm−2, respectively, which are comparable to the state-of-the-art nonprecious catalyst and commercial Pt/C. ORR catalysis on MOF–FeZn follows the nearly four-electron path. What is more, MOF–FeZn can sustain the 10,000 cycles electrochemical potential cycling process in acid with the half-wave potential changed only 21 mV, superior to the reduction of 149 mV for Pt/C. The well-developed integral uniform structures, homogeneously dispersed carbides and nitrides protected by the highly graphitic carbon layers and the better agglomeration suppression of nanoparticles by the confined graphitic carbon layers on catalyst can significantly enhance the catalytic activity and stability of MOF–FeZn.
Hematopoietic Stem Cell Transplantation Resolves the Immune Deficit Associated with STAT3-Dominant-Negative Hyper-IgE Syndrome
Authors: Harrison Stephanie C. , Tsilifis Christo , Slatter Mary A. , Nademi Zohreh , Worth Austen , Veys Paul , Ponsford Mark J. , Jolles Stephen , Al-Herz Waleed , Flood Terence , Cant Andrew J. , Doffinger Rainer , Barcenas-Morales Gabriela , Carpenter Ben , Hough Rachael , Haraldsson Ásgeir , Heimall Jennifer , Grimbacher Bodo , Abinun Mario , Gennery Andrew R. 
Published: February 2021

AbstractAutosomal dominant hyper-IgE syndrome caused by dominant-negative loss-of-function mutations in signal transducer and activator of transcription factor 3 (STAT3) (STAT3-HIES) is a rare primary immunodeficiency with multisystem pathology. The quality of life in patients with STAT3-HIES is determined by not only the progressive, life-limiting pulmonary disease, but also significant skin disease including recurrent infections and abscesses requiring surgery. Our early report indicated that hematopoietic stem cell transplantation might not be effective in patients with STAT3-HIES, although a few subsequent reports have reported successful outcomes. We update on progress of our patient now with over 18 years of follow-up and report on an additional seven cases, all of whom have survived despite demonstrating significant disease-related pathology prior to transplant. We conclude that effective cure of the immunological aspects of the disease and stabilization of even severe lung involvement may be achieved by allogeneic hematopoietic stem cell transplantation. Recurrent skin infections and abscesses may be abolished. Donor TH17 cells may produce comparable levels of IL17A to healthy controls. The future challenge will be to determine which patients should best be offered this treatment and at what point in their disease history.
Does it matter what your reasons are when deciding to disclose (or not disclose) a disability at work? The association of workers’ approach and avoidance goals with perceived positive and negative workplace outcomes
Authors: Gignac Monique A. M. , Jetha Arif , Ginis Kathleen A. Martin , Ibrahim Selahadin 
Published: February 2021

AbstractDeciding whether to disclose a disability to others at work is complex. Many chronic mental and physical health conditions are associated with episodic disability and include times of relative wellness punctuated by intermittent periods of activity limitations. This research draws on the disclosure processes model to examine approach and avoidance disclosure and non-disclosure goals and their association with perceived positive and negative workplace outcomes. Participants were 896 employed individuals (57.7% women) living with a chronic physical or mental health/cognitive condition. They were recruited from an existing national panel and completed an online, cross-sectional survey. Participants were asked about disclosure decisions, reasons for disclosure/non-disclosure, demographic, work context and perceived positive and negative disclosure decision outcomes (e.g., support, stress, lost opportunities). About half the sample (51.2%) had disclosed a disability to their supervisor. Decisions included both approach and avoidance goals. Approach goals (e.g., desire support, want to build trust, maintain the status quo at work) were significantly associated with perceived positive work outcomes regardless of whether a participant disclosed or did not disclose a disability at work, while avoidance goals (e.g., concerns about losing one’s job, feeling forced to disclose because others notice a problem) were associated with perceived negative work outcomes. The findings highlight benefits and challenges that workers perceive arise when they choose to disclose or not disclose personal health information. By better understanding disclosure decisions, we can inform organizational health privacy and support gaps to help sustain the employment of people living with disabilities.
Using a landscape ecological perspective to analyze regime shifts in social–ecological systems: a case study on grassland degradation of the Tibetan Plateau
Authors: Li Li , Fassnacht Fabian Ewald , Bürgi Matthias 
Published: February 2021

Abstract
Context
Landscape ecology thinking and social–ecological system (SES) thinking investigate human–environment relationships from the perspective of ‘space’ and ‘system’, respectively. To date, empirical landscape ecology studies attempting to understand SES complexities are rare.

Objectives
Using the Tibetan pastoral landscape as an empirical example, we conceptualize the black-soil formation as SES regime shifts. We seek to illustrate the spatial patterns of black-soil formation in the Tibetan SES, and to reveal their underlying ecological processes.

Methods
We conducted interdisciplinary research in a Tibetan pastoral village. We obtained quantitative data on historical land-use intensity (LUI) and the associated management narratives. Landsat-based NDVI time series were used to derive a grassland productivity proxy and to reconstruct the process leading to the up-scaling of the regime shift of degradation.

Results
Important SES features, such as LUI, productivity and degradation risk are heterogeneously distributed in space. Land-use intensification at farm-scales in the 1990s increased landscape-scale degradation risks. Eventually the regime shift of degradation scaled up from the plot level to the landscape level in the 2010s. The time lag was related to the gradual invasion of a native burrowing animal, the plateau pika, which inhabits low-vegetation height pastures.

Conclusions
Our study shows that landscape ecology thinking provides an important spatial perspective to understanding SES complexities. The finding that unfavorable SES regime shifts are strongly linked across spatial scales implies that an ‘entry point’ into an adaptive management circle should be initiated when local-scale regime shifts are perceived and interpreted as early warning signals.
Decision-making in Shiatsu bodywork: complementariness of embodied coupling and conceptual inference
Authors: Kimmel Michael , Irran Christine 
Published: February 2021

Abstract“4E” cognitive science has demonstrated that embodied coupling offers powerful resources for reasoning. Despite a surge of studies, little empirical attention is paid to discussing the precise scope of these resources and their possible complementariness with traditional knowledge-based inference. We use decision-making in Shiatsu practice – a bodywork method that employs hands-on interaction with a client – to showcase how the two types of cognitive resources can mesh and offer alternative paths to a task: “Local” resources such as embodied presence, empathy, attunement, as well as skilled perception-action coupling are not only central for implementing a successful therapeutic intervention. The immediate coupling with a client also offers basic means of deciding about fitting and meaningful interventions. Yet, when comprehensive intervention strategies are at stake, Shiatsu decision making must be complemented through “non-local” resources, notably inferences rooted in anatomy/physiology knowledge, categories, heuristics, and mental models. To draw out implications for “4E” cognitive science, we argue that “local” embodied coupling and “non-local” conceptual inferences can functionally complement, inform, and scaffold each other in a dialectic process.
Small-Scale Dynamic Aurora
Authors: Kataoka Ryuho , Chaston Christopher C. , Knudsen David , Lynch Kristina A. , Lysak Robert L. , Song Yan , Rankin Robert , Murase Kiyoka , Sakanoi Takeshi , Semeter Joshua , Watanabe Tomo-Hiko , Whiter Daniel 
Published: February 2021

AbstractSmall-scale dynamic auroras have spatial scales of a few km or less, and temporal scales of a few seconds or less, which visualize the complex interplay among charged particles, Alfvén waves, and plasma instabilities working in the magnetosphere-ionosphere coupled regions. We summarize the observed properties of flickering auroras, vortex motions, and filamentary structures. We also summarize the development of fundamental theories, such as dispersive Alfvén waves (DAWs), plasma instabilities in the auroral acceleration region, ionospheric feedback instabilities (IFI), and the ionospheric Alfvén resonator (IAR).
Germination, root elongation, and photosynthetic performance of plants exposed to sodium lauryl ether sulfate (SLES): an emerging contaminant
Authors: Salvatori Elisabetta , Rauseo Jasmin , Patrolecco Luisa , Barra Caracciolo Anna , Spataro Francesca , Fusaro Lina , Manes Fausto 
Published: February 2021

AbstractThe anionic surfactant SLES (sodium lauryl ether sulfate) is an emerging contaminant, being the main component of foaming agents that are increasingly used by the tunnel construction industry. To fill the gap of knowledge about the potential SLES toxicity on plants, acute and chronic effects were assessed under controlled conditions. The acute ecotoxicological test was performed on Lepidum sativum L. (cress) and Zea mays L. (maize). Germination of both species was not affected by SLES in soil, even at concentrations (1200 mg kg−1) more than twice higher than the maximum realistic values found in contaminated debris, thus confirming the low acute SLES toxicity on terrestrial plants. The root elongation of the more sensitive species (cress) was instead reduced at the highest SLES concentration. In the chronic phytotoxicity experiment, photosynthesis of maize was downregulated, and the photosynthetic performance (PITOT) significantly reduced already under realistic exposures (360 mg kg−1), owing to the SLES ability to interfere with water and/or nutrients uptake by roots. However, such reduction was transient, likely due to the rapid biodegradation of the surfactant by the soil microbial community. Indeed, SLES amount decreased in soil more than 90% of the initial concentration in only 11 days. A significant reduction of the maximum photosynthetic capacity (Pnmax) was still evident at the end of the experiment, suggesting the persistence of negative SLES effects on plant growth and productivity. Overall results, although confirming the low phytotoxicity and high biodegradability of SLES in natural soils, highlight the importance of considering both acute and nonlethal stress effects to evaluate the environmental compatibility of soil containing SLES residues.
In vitro estrogenic, cytotoxic, and genotoxic profiles of the xenoestrogens 8-prenylnaringenine, genistein and tartrazine
Authors: Nasri Atefeh , Pohjanvirta Raimo 
Published: February 2021

AbstractPhytoestrogens have been widely praised for their health-promoting effects, whereas synthetic environmental estrogens are considered a toxicological risk to human health. The aim of this study was therefore to compare in vitro the estrogenic, cytotoxic, and genotoxic profiles of three common estrogen-like endocrine-disrupting chemicals: the phytoestrogens 8-prenylnaringenine (8-PN) and genistein and the synthetic xenoestrogen tartrazine. As assessed by a yeast bioreporter assay and estrogen-dependent proliferative response in human mammary gland adenocarcinoma cell line (MCF-7), 8-PN showed the highest estrogen-like activity of the three compounds, followed by tartrazine and genistein. After 24-h incubation on MCF-7 cells, all three compounds exhibited low cytotoxicity in the lactate dehydrogenase assay and no genotoxicity in the micronucleus assay. These results demonstrate that 8-PN, genistein and tartrazine possess variable estrogenic activity but display little cellular toxicity in short-term tests in vitro. No difference between phytoestrogens and a synthetic xenoestrogen could be established.