bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging Characteristics of Primary Non-Hodgkin's Lymphoma of The Larynx
Authors: Chen Xinyi , Kuang Pingding , Ding Qiaoling , Wang Zijian , Jiang Biao 
Published: September 2021

Abstract
Purpose

This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI)characteristics of primary Non-Hodgkin's Lymphoma (NHL) of the larynx.
Materials and methods

The radiographic examinations of five patients (2 men, 3 women; median age, 68years) with histopathologically proven NHL of the larynx were retrospectively reviewed. CT and MRI images were analyzed qualitatively (Tumor distribution, Local tumor invasion, Tumor appearance, Cervical lymphadenopathy of NHL).
Results

CT and MRI images showed no obvious signs of vascular and laryngeal cartilage invasion. Three cases (1 MALT, 2 diffuse large B-cell lymphomas (DLBCL)) were centered in the supraglottic region involved the glottis (3/3) and subglottic (1/3). Two cases (MALT) were centered in the glottis involved the subglottic. The laryngeal tumors involved the true cords (5 cases), aryepiglottic folds (3 cases), ventricles and false cords (3 cases), anterior commissure (2 cases). On MRI (4 cases), all NHL presenting as homogeneous intermediate T1-weighted, heterogeneous slightly high T2-weighted mass with homogeneous moderate to evident enhancement. The mucosa with more obvious enhancement and smooth surface could be seen. On CT (1 plain and 3 contrast-enhanced), all tumors were homogeneous moderate density, and no necrosis or calcifications were seen. Lymphadenopathy was presented in two patients of DLBCL without necrosis.
Conclusions

On MRI or CT, when the laryngeal mass is located under the mucosa with uniform density or signal intensity, smooth surface, moderate to obvious homogeneous enhancement without cystic, necrosis, calcification and cartilage destruction, the radiologist should consider that it is likely to be NHL, especially when the mass spreads upwards to the oropharynx, nasopharynx and Webster's lymphoid ring. Further studies however are needed to confirm our findings obtained in a limited number of patients.
Effect of Continues Midwifery Support in Labor on the Childbirth Experience and Self-Esteem of Primipara Women: A Randomized Controlled Trial
Authors: Soleimani Nasrin , Refaei Mansoureh , Kazemi Farideh 
Published: September 2021

Abstract
Background: The World Health Organization states that mothers during labor and delivery should be supported by people with whom they feel comfortable, because one of the non-pharmacological methods of relieving labor pain is the continued support of midwives in labor. The primary objectives of this study were to determine the effect of continuous midwifery support in labor on delivery experience and self-esteem of nulliparous women 6 weeks after delivery.Methods: This randomized controlled trial was performed in 2021 on 70 pregnant women admitted to the delivery ward who met the inclusion criteria. Participants were randomly allocated to two groups through balanced block randomization with a block size of 4. Participants completed a demographic and midwifery information questionnaire before entering the study. In the intervention group, in addition to routine labor care, the researcher was present at the mother's bedside and was present with the mother continuously throughout the labor and up to 2 hours after delivery and provided the necessary support. The control group received only routine labor and postpartum care. Six weeks after delivery, participants in both groups were contacted to complete the CEQ and Rosenberg self-esteem questionnaires. Finally, data were collected and analyzed. Significance level was considered 0.05.Results: By controlling the effect of duration of the first and second stages of labor as potential confounders, the mean (sd) of childbirth experience 6 weeks after delivery was 70.92 (7.07) in the intervention group and 59.69 (7.08) in the control group, and this difference was statistically significant (p <0.001). The amount of effect size indicates a very strong effect of the intervention on improving the childbirth experience (Cohen’s d = 1.69; 95% CI: 1.12, 2.26). Comparison of the mean of maternal self-esteem showed that this rate in the intervention group was 2 scores higher than the control group and this difference was statistically significant (p = 0.05). Cohen's d indicates the average effect of intervention on mothers' self-esteem score (Cohen's d = 0.56; 95% CI: 0.06, 1.05).Conclusions: Continuous support of the midwife in labor and up to 2 hours after delivery can lead to a better childbirth experience and increase the mother's self-esteem up to 6 weeks after delivery.Trial registration: IRCT ID: IRCT20201102049233N1, First Registration date: 2021-06-04
Predicting CO2 Trapping Efficiency In Saline Aquifers By Machine Learning System: Implication To Carbon Sequestration
Authors: Vo-Thanh Hung , Lee Kang-Kun 
Published: September 2021

Abstract
Carbon dioxide (CO2) storage in saline formations has been identified as a practical approach to reducing CO2 levels in the atmosphere. The residual and solubility of CO2 in deep saline aquifers are essential mechanisms to enhance security in storing CO2. In this research, CO2 residual and solubility in saline formations have been predicted by adapting three Machine Learning models called Random Forest (RF), extreme gradient boosting (XGboost), and Support Vector Regression (SVR). Consequently, a diversity of the field-scale simulation database including 1509 data samples retrieved from reliable studies, was considered to train and test the proposed models to achieve this task. Graphical and statistical indicators were evaluated and compared the predictive ML model performance. The predicted results denoted that the proposed ML models are ranked from high to low as follows: XGboost>RF>SVR. Additionally, the performance analyses revealed that the XGboost model demonstrates higher accuracy in predicting CO2 trapping efficiency in saline formation than previous ML models. The XGboost model yields very low root mean square error (RMSE) and R2 for both residual and solubility trapping efficiency. At last, the applicable domain of XGboost model was validated, and only 24 suspected data points were recognized from the entire databank.
Single Center First Year Experience And Outcomes With Impella 5.5 Left Ventricular Assist Device
Authors: Rock Joanna Rose , Kos Cynthia A , Lemaire Anthony , Ikegami Hirohisa , Russo Mark J , Moin Danyaal , Dulnuan Kenneth , Iyer Deepa 
Published: September 2021

Abstract
BackgroundThe Impella 5.5® was approved by the FDA for use for mechanical circulatory support up to 14 days in late 2019 at limited centers in the United States. Our single center’s experience with Impella 5.5® can expand the overall understanding for achieving successful patient outcomes as well as provide support for the expansion of its FDA-approved use.Methods This study is an IRB-approved single-center retrospective cohort analysis of hospitalized adult patient characteristics and outcomes in cases where the Impella 5.5® was utilized for mechanical circulatory support.Results A total of 26 implanted Impella 5.5® devices were identified in 24 hospitalized patients at our institution from January 2020 to January 2021. The overall survival rate during index hospitalization was 75%. Eleven Impella 5.5® devices were identified in 10 patients with an average device implantation greater than 14 days. Average device implantation for this subgroup was 27 days with a range of 15-80 days. Survival rate for Impella 5.5® use greater than 14 days was 67%. In the entire cohort and subgroup of device implantation >14 days, evidence of end organ damage improved with Impella 5.5® use. Complications in our cohort and subgroup of device implantation >14 days were similar to previously reported complication incidence of axillary inserted LVAD devices. Conclusions Our institution’s experience with the Impella 5.5® has been strongly positive with favorable outcomes and helps to establish the Impella 5.5® as a viable option for mechanical circulatory support beyond 14 days.
Tumor-Immune Partitioning and Clustering (TIPC): an algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment
Authors: Nowak Jonathan , Lau Mai Chan , Borowsky Jennifer , Väyrynen Juha , Haruki Koichiro , Zhao Melissa , Costa Andressa Dias , Gu Simeng , Silva Annacarolina Da , Arima Kota , Yeong Joe , Felt Kristen , Hamada Tsuyoshi , Nishihara Reiko , Lennerz Jochen , Fuchs Charles , Wu Catherine , Meyerhardt Jeffrey , Ogino Shuji 
Published: September 2021

Abstract
Growing evidence supports the importance of quantifying tumor-immune cell interactions in the tumor microenvironment to enable precision cancer therapy. However, most existing methods rely solely upon immune cell density or nearest neighbor-type analyses and fail to fully characterize spatial heterogeneity. Herein, we describe a computational algorithm, termed Tumor-Immune Partitioning and Clustering (TIPC), that jointly measures immune cell partitioning between tumor epithelial and stromal areas and immune cell clustering versus dispersion. As proof of principle, we apply TIPC to two large colorectal cancer cohorts. TIPC identifies tumor subtypes with unique interaction signatures between tumor cells and T cells that harbor prognostic significance and are associated with distinct tumor molecular features. We extend our findings by applying TIPC to additional immune cell types identified using morphology and supervised machine learning. Spatial heterogeneity quantification and novel tumor subtype identification by TIPC may inform precision cancer immunotherapy and deepen our understanding of tumor immunobiology.
Prediction And Potential Detection of Land Subsidence By Integrating AHP And Programming Methods: Case Study of South Eastern Iran
Authors: Pourmorad Saeid , Mohanty Ashutosh , Dash Sushree Sangita , Das Ajoy , Moein Zeinab 
Published: September 2021

Abstract
One of the biggest risks that need to be considered before any construction operation such as road construction or construction is to determine the exact location of subsidence and predict the places with the potential to cause these complications.There are various methods for identifying and predicting the occurrence of these phenomena. In this article, hierarchical analysis methods (AHP and FAHP) and programming in MATLAB environment with the help of Evalfis function to study and map these hazards in the southwest of Iran has acted as a case study.Studies of lithological layers, slope, distance from fault and distance from waterway in both methods express very good and significant results in predicting this type of hazards.According to these results, the most hazards occur in places that have evaporitic lithology and have the shortest distance from waterways and faults with a slope between 20 to 70 degrees.The output of these studies is to provide a map of subsidence (sinkhole) hazards for the first time by integrating the stated methods with operational accuracy above 90% and introducing a very useful software in MATLAB program for experts.
Effects of Partial Saturation on Nitrogen Removal and Bacterial Community in Vertical-Flow Constructed Wetlands
Authors: kraiem Khadija , Kallali Hamadi , Ammeri Rim Werheni , Bessadok salma , Jedidi Naceur 
Published: September 2021

Abstract
The laboratory-scale pilot of constructed wetlands has been in operation for six months; (1) an unsaturated vertical flow constructed wetland (UVF-CW), this system was used to represent the classic vertical constructed wetlands, (2) a saturated vertical flow constructed wetland (SVF-CW), to evaluate the effects of the saturated condition on nitrogen removal and composition of the microbial community. The results showed that the saturation condition positiveley influenced the removal efficiencies of the nitrogen,, the aeverage removal rate of the total kjeldahl nitrogen increased from 56% in unsaturated vertical flow constructed wetland (UVF-CW) to 63% in saturated vertical flow constructed wetland ( SVF-CW). In addition, the microbial communities also was affected by the saturation condition, the relative abundances of nitrifying bacterium in UVF-CW are 13.8% (Nitrosomonas), 7.2% (Nitrosospira), 18.1% (Nitrospira) and 15.3% (Nitrobacter). In contrast, in SVF-CW, Nitrosomonas, Nitrosospira, Nitrospira and Nitrobacter only accounted for 6.8%, 5.6%, 7.4% and 10.6% respectively. However, the saturation condition seemed to increase denitrifying bacterium more than three times, in unsaturated vertical flow constructed wetland, only Pseudomonas (6.5%) and Paracoccus (4.85%) were detected, but in saturated vertical flow constructed wetland (SVF-CW), the abundance of Pseudomonas (13.08%) and Paracoccus (9.74%) were increased, and three other groups of denitrifying bacteria were also detected as Zoogloea (3.32%), Thauera (5.41%) and Thiobacillus (3).
Singular Nonlinear Equation Class : Theoretical and Experimental Concept
Authors: Nguetcho Aurélien Serge Tchakoutio 
Published: September 2021

Abstract
This work generalizes and extends our work in refs [10,29,37], dealing a theoretical model of a monoatomic chain immersed in a potential of periodic and deformable substrate, the third and fourth non-linearities being taken into account. Looking at the analytical localized modes provides an extended interpretation of system dynamics based upon modes existence and yields an extended form of the nonlinear Schrodinger equation to describe the eikonal wave's complex amplitude. In this equation, the coeffcients depend on the wavenumber, whereas the parallel with the nonlinear transmission electrical line introduced in references results in [1,2] not fully resolved dynamic equations. So far, only specific solutions have been presented. Our dynamic study thus presents a theoretical prediction for their experimental set up. In contrast to previous works done for particular values of the wavenumber, namely on the behavior of gap (k = 0 and k = π) solutions of the model [10], or for k (k = ±2π=3) in the central bandpass area [37], we consider here rather behaviors of the system when the angular frequency is arbitrary. By using bifurcation theory of planar dynamical systems and investigating the dynamical behavior, we derive a variety of solutions corresponding to the phase trajectories under different parameter conditions.
RNASeq Analysis of a Pax3-Expressing Myoblast Clone in-Vitro and Effect of Culture Surface Stiffness on Differentiation
Authors: Richardson Louise , Wang Dapeng , Hughes Ruth , Johnson Colin A , Peckham Michelle 
Published: September 2021

Abstract
Skeletal muscle satellite cells cultured on soft surfaces (12kPa) show improved differentiation than cells cultured on stiff surfaces (approximately 100kPa). To better understand the reasons for this, we performed an RNASeq analysis for a single satellite cell clone (C1F) derived from the H2kb-tsA58 immortomouse, which differentiates into myotubes under tightly regulated conditions (withdrawal of ɣ-interferon, 37°C). As expected, the largest change in overall gene expression occurred at day 1, as cells switch from proliferation to differentiation. Surprisingly, further analysis showed that proliferating C1F cells express Pax3 and not Pax7, confirmed by immunostaining, yet their subsequent differentiation into myotubes is normal, and enhanced on softer surfaces, as evidenced by significantly higher expression levels of myogenic regulatory factors, sarcomeric genes, enhanced fusion and improved myofibrillogenesis. Levels of RNA encoding extracellular matrix structural constituents and related genes were consistently upregulated on hard surfaces, suggesting that a consequence of differentiating satellite cells on hard surfaces is that they attempt to manipulate their niche prior to differentiating. This comprehensive RNASeq dataset will be a useful resource for understanding Pax3 expressing cells.
Manipulating Stress Receptor Signaling to Enhance Immunosuppression and Prolong Survival of Vascularized Composite Tissue
Authors: Kim Minhyung , Fisher Daniel , Bogner Paul , Sharma Umesh , Skitzki Joseph , Repasky Elizabeth 
Published: September 2021

Abstract
Vascularized composite tissue allotransplantation (VCA) can replace severely damaged body parts but the unavoidable toxicity of high doses of immunosuppressive drugs, such as tacrolimus, required results in significant morbidity. Here we tested whether we could suppress immune activity in a mouse model of VCA by mimicking the natural immune suppression generated by nervous system-induced signaling of adrenergic receptors (AR) by using a safe and well-studied β-AR agonist (terbutaline). Using wild-type and β2-AR-knockout (KO) mice, we found that increased β2-AR signaling results in delayed rejection in VCA recipients, even with subtherapeutic doses of tacrolimus, and this was associated with changes in immune contexture, expression of pro-inflammatory cytokines and chemokines, and function of endothelial adhesion molecules. We propose that β-AR agonists can be used safely to mimic the natural suppression of immune responses generated by adrenergic stress signaling and thereby reduce the dose needed of other more toxic immunosuppressive drugs.
Resilience to Early Family Risk Moderates Daily Stress and Affect on Cortisol Diurnal Slope associations: A 14-Day Ecological Momentary Assessment Study
Authors: Tung Natasha Yan Chi , Yap Yang , Bei Bei , Luecken Linda , Wiley Joshua 
Published: September 2021

Abstract
ObjectiveThis study examined whether resilience capacity moderates the impact of daily perceived stress and affect on cortisol diurnal slope among relocated emerging adults. MethodsRelocated undergraduates (N=98; aged 18-25 years) were recruited from three groups: Resilient, Vulnerable, and Control. Mixed-effects models were used to test the unique effects of perceived stress, negative affect, and positive affect x group interactions on diurnal cortisol slope across 14 consecutive days.ResultsThe Resilient group did not moderate the associations between daily stress or affect on cortisol diurnal slope. Instead, both the Resilient and Vulnerable groups with early family risk, showed a steeper diurnal slope unique to higher stress and a flatter slope unique to higher NA.ConclusionsResults suggest that an adverse early family life was significantly associated with altered cortisol diurnal slope outcomes to stress (i.e., demand) and negative affect (i.e., distress). These associations were not attenuated by current resilience capacity.
Pretreatment of Natural Lignocellulose With Inorganic Salts Improves Ligninase Production Fermented By Aspergillus Fumigatus
Authors: Zhou Zijing , Guo Gaijuan , Li Jinda , Yan Hong , Li Fen 
Published: September 2021

Abstract
This work screened out the optimal conditions for pretreatment of natural lignocellulose with inorganic salts and provided a simple, easy-to-operate, low-cost, clean and efficient pretreatment method for the efficient degradation of natural lignocellulose by strains. The results showed that the optimal pretreatment inorganic salt was FeCl2 with a concentration of 11%, pretreatment at 60°C for 48 h, and the solid-liquid ratio was 1:11 (g/mL). According to the characterization results, after pretreatment of FeCl2 solution, the smooth and dense structure of natural lignocellulose surface became rough and irregular, and surface fiber bundles showed spalling and fracture. Subsequently, the enzymes produced by solid-state fermentation of Aspergillus fumigatus were easier to enter the interior, which increased the contact area between materials and enzymes, and increased the amount of enzymatic loads, thereby improving the biodegradation effect.
Skin Oncoplasties: Is Z-Plasty A Technique of Choice In Situation of Limited Resources? Case of Burkina Faso.
Authors: ZONGO Nayi , Ouédraogo NL Marie , Mamadou Windsouri , Yameogo Laure SC , CHABI Thierry R. KOUCHIKA , Niamba Pascal , Traoré Adama 
Published: September 2021

Abstract
Background: In developing countries, the long delays in consultation lead to a delay in diagnosis and management of the skin tumours. The lesions are often large and brings the problem of skin coverage after their resections. Several reconstruction techniques allow skin coverage. The objective of this study is to describe the place of Z-plasty in the surgical treatment of skin cancers in Ouagadougou.Patients and methods: It was a two-centre, retrospective, descriptive study on Z-plasty in skin cancers. It included patients who underwent surgery between January 1st, 2013 and March 30th, 2021 in Ouagadougou. Scar quality and healing time in Z-plasty were compared with those of secondary healing. Results: In 8 years and 3 months, 171 skin cancers were identified. The mean time to consultation was 13.6 months. The average size of the tumours was 9 cm. A Z-plasty was performed in 42 cases, being 58.3% of the patients operated on. The average healing time was 15 days. It was four and a half times shorter in Z-plasty than in secondary healing. Ischaemic necrosis of the Z-corner was noted in 7 cases. The recurrence rate in Z-plasty and secondary healing was 7.1% and 9.1% respectively. Hypertrophic or keloidal scars were noticed in 7 cases and hypochromia in 2 cases.Conclusion: Z-plasty is a technique of choice for skin coverage after large resections in surgical oncology. It reduces the healing time and the cost of postoperative care without increasing the risk of tumour recurrence.
Overview of Some Factors Affecting The Durability And Efficacy of LLINs Used By The Communities In South Region of Cameroon, Central Africa
Authors: AKONO Patrick NTONGA , Mbongue Serge , Hondt Odette Ngo , Takap Francis Noel Nopowo , Ngaha Rachel , Tekapi Williefred Dongmo , Ambeme Parfait Awono , Nkondjio Antonio , Ngoa Laurent Serges Etoundi 
Published: September 2021

Abstract
Background: Long-lasting insecticidal nets (LLINs) are widely used in sub-Saharan Africa to control the transmission of malaria parasites by Anopheles mosquitoes. However, their operational lifespan depends on numerous factors that are often not considered. This paper investigates on some of these factors likely associated with the rapid breakdown of LLINs efficacy in urban and rural locations of the seaport city of Kribi, South Region of Cameroon.Methods: The cross-sectional study conducted in June 2019 included: (i) a household survey using standard questionnaire for brands of LLINs used, their maintenance, and coverage rates in study communities, (ii) assessment of the physical integrity of nets, and (iii) WHO cone bioassays to check the residual efficacy of the nets against wild strains and susceptible reference laboratory strains of Anopheles gambiae s. l. species.Results: A total of 540 households were surveyed, 235 in urban Kribi and 305 in rural Kribi. The overall net coverage rate per sleeping space was 68.82%, irrespectively with a similar trend between rural Kribi (68.98%) and urban Kribi (68.62%) (p = 0.929). Of the 1,211 LLINs counted, 64.73% were Interceptor®, 25.44% were PermaNet®, 4.68% were Olyset Net ; the remainder (05.13%) belonged to Yorkool®, Royal Sentry®, Netto®, Super Net® and Panda Net®. Proportional hole index analysis showed that Permanet 2.0 nets (1435±117.462) were more degraded than other brands after more than 36 months of use in rural Kribi, whereas Yorkool nets (2004±328.833) were more degraded in urban Kribi. Polyethylene fibers were not significantly more degraded than polyester fibers. The bio efficacy tests showed that LLINs washed more than 20 times induced mortality from 21.6% to 99.6% for the Kisumu strain and from 0.8% to 76.50% for the wild strain. LLINs washed with Marseille soap retained their lethal properties significantly more than LLINs washed with corrosive detergents (p=0.000). Similarly, LLINs spread in the shade retained their lethal properties more than those spread in the sun.Conclusion: Corrosive detergents and sunlight are factors that negate the toxic effect of insecticide impregnation of LLINs. Awareness campaigns are needed to encourage people to adopt good LLIN care practices.