bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and In Vivo Study
Authors: Singh Babita , Pandey Shivani , Rumman Mohammad , Kumar Shashank , Kushwaha Prem Prakash , Verma Rajesh , Mahdi Abbas Ali 
Published: March 2021

Ethnopharmacological Relevance:Parkinson’s disease (PD) is characterized by progressive death of dopaminergic neurons. The presently used medicines only tackle the symptoms of PD, but none makes a dent on the processes that underpin the disease’s development. Herbal medicines have attracted considerable attention in recent years.Bacopa monnieri(L.)Wettst(Brahmi) has been used in Indian Ayurvedic medicine to enhance memory and intelligence. Herein, we assessed the neuroprotective role ofBacopa monnieri(L.)Wettston Parkinson’s disease.Aim of the Study:Bacopa monnieri(L.)Wettst, a medicinal herb, is widely used as a brain tonic. We investigated the neuroprotective and neurorescue properties ofBacopa monnieri(L.)Wettstextract (BME) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of PD.Materials and Methods:The mice model of MPTP-induced PD is used in the study. In the neuroprotective (BME + MPTP) and neurorescue (MPTP + BME) experiments, the animals were administered 40 mg/kg body weight BME orally before and after MPTP administration, respectively. Effect of BME treatment was evaluated by accessing neurobehavioral parameters and levels of dopamine, glutathione, lipid peroxide, and nitrites. Anin silicostudy was performed using AutoDock Tools 1.5.6 (ADT).Results:A significant recovery in behavioral parameters, dopamine level, glutathione level, lipid peroxides, and nitrite level was observed in BME-treated mice. Treatment with BME before or after MPTP administration has a protective effect on dopaminergic neurons, as evidenced by a significant decrease in GFAP immunostaining and expression of inducible nitric oxide synthase (iNOS) in the substantia nigra region; however, the degree of improvement was more prominent in mice receiving BME treatment before MPTP administration. Moreover, thein silicostudy revealed that the constituents of BM, including bacosides, bacopasides, and bacosaponins, can inactivate the enzyme monoamine oxidase B, thus preventing the breakdown of MPTP to MPP+.Conclusion:Our results showed that BME exerts both neuroprotective and neurorescue effects against MPTP-induced degeneration of the nigrostriatal dopaminergic neurons. Moreover, BME may slow down the disease progression and delay the onset of neurodegeneration in PD.
Psychosocial Framework of Resilience: Navigating Needs and Adversities During the Pandemic, A Qualitative Exploration in the Indian Frontline Physicians
Authors: Banerjee Debanjan , Sathyanarayana Rao T. S. , Kallivayalil Roy Abraham , Javed Afzal 
Published: March 2021

IntroductionFrontline healthcare workers (HCW) have faced significant plight during the ongoing Coronavirus disease 2019 (COVID-19) pandemic. Studies have shown their vulnerabilities to depression, anxiety disorders, post-traumatic stress, and insomnia. In a developing country like India, with a rising caseload, resource limitations, and stigma, the adversities faced by the physicians are more significant. We attempted to hear their “voices” to understand their adversities and conceptualize their resilience framework.MethodsA qualitative approach was used with a constructivist paradigm. After an initial pilot, a socio-demographically heterogeneous population of 172 physicians working in COVID-designated centers were purposively sampled from all over India. Following in-depth virtual interviews using a pre-formed semi-structured guide, the data was transcribed and translated verbatim. The interview was focused on their challenges, needs, and processes of coping and support. Charmaz’s grounded theory was used for analysis supplemented by NVivo 10 software.ResultsFear of infection, uncertainty, stigma, guilt, and social isolation emerged as the main challenges. Simultaneously, their “unmet needs” were flexible work policies, administrative measures for better medical protection, the sensitivity of media toward the image of HCW, effective risk communication for their health, and finally, social inclusion. Their resilience “framework” emerged as a process while navigating these adversities and consisted of three facets: forming a “resilient identity,” managing the resilience, and working through the socio-occupational distress. The role of mental well-being, social network, peer support, problem negotiation, and self-care emerged as the key coping strategies.ConclusionThe study findings support the global call for better psychosocial health and quality of life of the frontline HCWs. Their “unheard voices” explored in the study can anchor subsequent resilience-enhancing interventions and policies. Guidelines focusing on the psychological wellbeing of frontline HCWs need to be grounded in their unmet needs and lived experiences.
Mediating Effect of Personal Meaning in the Prediction of Life Satisfaction and Mental Health Problems Based on Coronavirus Suffering
Authors: Arslan Gökmen , Yıldırım Murat , Leung Mega M. 
Published: March 2021

Research Problem: The onset of the COVID-19 pandemic has triggered a multi-faceted crisis worldwide. Researchers and health authorities in various parts of the world echoed the dire condition of the public's mental health. This study sought to examine the mediating effect of personal meaning on the association between coronavirus (COVID-19)-related suffering, mental health problems, and life satisfaction. Participants included 231 adults (mean age = 46.65 ± 13.98; 68% female) and completed measures of suffering related to COVID-19, meaning, life satisfaction, and mental health problems online.Results: Findings from mediation analysis showed that suffering had significant associations with personal meaning, mental health, and well-being. Furthermore, personal meaning was significantly associated with adults' mental health and well-being and mediated the negative effect of suffering on mental health and well-being.Discussion: Overall, results from this study indicate that personal meaning is an important promotive factor that may help to understand the negative effect of coronavirus-related suffering on mental health and well-being amid the public health crisis.
Health-Related Quality of Life and Its Influencing Factors for Elderly Patients With Hypertension: Evidence From Heilongjiang Province, China
Authors: Zheng Erwei , Xu Jiao , Xu Juan , Zeng Xueyun , Tan Wan Jie , Li Jinmei , Zhao Miaomiao , Liu Bo , Liu Rui , Sui Mingjie , Zhang Zhong , Li Yang , Yang Hongbin , Yu Hongjuan , Wang Yongqing , Wu Qunhong , Huang Weidong 
Published: March 2021

Objective: Hypertension is one of the most common public health issues worldwide. However, few existing studies examining health-related quality of life (HRQoL) were conducted on elderly patients with hypertension in China. Hence, this study aimed to assess the HRQoL of elderly patients with hypertension and its influencing factors using EuroQol five-dimensional-three-level (EQ-5D-3L) in China.Methods: Data were obtained from the 6th National Health Service Survey in Heilongjiang province from June to July 2018, with a stratified multistage random cluster sampling method. All eligible participants were interviewed using a standardized questionnaire, which included the EQ-5D-3L, socio-demographics characteristics, clinical and lifestyle characteristics. The mean EQ-5D index scores for the different subgroups were evaluated using ANOVA. A Tobit regression model was also employed to analyze the potential factors influencing HRQoL.Results: A total of 705 elderly patients with hypertension were included in this study. The mean EQ-5D utility score was 0.79 [standard deviation (SD) = 0.23]. The proportion of participants reporting pain/discomfort problems was the highest (57.0%), while problems in self-care was the lowest (17.2%). Influencing factors of HRQoL for elderly patients with hypertension included gender, age, income, education level, physical activity, health examination and coexisting diseases. Specifically, the female gender, being above 80 years old, having a lower education and/or higher income, and the presence of coexisting diseases were associated with lower utility index. In contrast, regular physical activity and medical examination had a positive impact on the HRQoL of elderly hypertension patients.Conclusion: Overall, elderly patients with hypertension in China have a lower HRQoL than the general population. To improve the HRQoL of elderly patients with hypertension, it is imperative that better public health education is provided to enhance the knowledge of hypertension, encourage the adoption of healthy habits such as regular physical activity and medical examination, and improve the management of coexisting diseases. More care should also be directed to males with hypertension who are above 80 years old.
Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma
Authors: Al-Khan Awf A. , Al Balushi Noora R. , Richardson Samantha J. , Danks Janine A. 
Published: March 2021

Osteosarcoma (OS) is the most common primary bone tumor and originates from bone forming mesenchymal cells and primarily affects children and adolescents. The 5-year survival rate for OS is 60 to 65%, with little improvement in prognosis during the last four decades. Studies have demonstrated the evolving roles of parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) in bone formation, bone remodeling, regulation of calcium transport from blood to milk, regulation of maternal calcium transport to the fetus and reabsorption of calcium in kidneys. These two molecules also play critical roles in the development, progression and metastasis of several tumors such as breast cancer, lung carcinoma, chondrosarcoma, squamous cell carcinoma, melanoma and OS. The protein expression of both PTHrP and PTHR1 have been demonstrated in OS, and their functions and proposed signaling pathways have been investigated yet their roles in OS have not been fully elucidated. This review aims to discuss the latest research with PTHrP and PTHR1 in OS tumorigenesis and possible mechanistic pathways.This review is dedicated to Professor Michael Day who died in May 2020 and was a very generous collaborator.
Experimental Investigation of Aerosol and CO2 Dispersion for Evaluation of COVID-19 Infection Risk in a Concert Hall
Authors: Schade Wolfgang , Reimer Vladislav , Seipenbusch Martin , Willer Ulrike 
Published: March 2021

The dispersion of small aerosols in a concert hall is experimentally studied for estimating the risk of infection with SARS-CoV-2 during a concert. A mannequin was modified to emit an air stream containing aerosols and CO2. The aerosols have a size distribution with a peak diameter (δ) close to 0.3 µm and a horizontal initial particle velocity (vp,x) of 2.4 m/s. The CO2-concentration (c) emitted simultaneously is 7500 ppm. It is investigated, if the spatial dissipation of aerosols and CO2 can be correlated. This would allow the use of technically easier CO2 measurements to monitor compliance with aerosol concentration limits. Both aerosol and CO2 concentrations are mapped by different sensors placed around the mannequin. As a result, no significant enrichment of aerosols and CO2 was obtained outside a radius of 1.5 m when the fresh air ventilation in the concert hall has a steady vertical flow with a velocity of vg,z=0.05 m/s and the installed ventilation system was operating at an air change rate per hour (ACH) of 3, corresponding to an air exchange rate of 51,000 m3/h. A Pearson correlation coefficient of 0.77 was obtained for CO2 and aerosol concentrations measured simultaneously at different positions within the concert hall.
El Romancero aux étoiles de Jacques Stephen Alexis como sutura de una nación escindida
Authors: Viterbo Florencia 
Published: March 2021

En 1960, Jacques Stephen Alexis, como continuador del indigenismo haitiano cuya piedra angular es el Ainsi parla l’oncle de Jean Price Mars, publica Romancero aux étoiles, un libro de relatos en donde invita a un lectorado culto a defender las raíces de lo popular haitiano, para suturar una nación escindida en una acomodada elite urbana y una masa analfabeta de campesinos.
Entrelazando una oralidad de rasgos populares con una escritura neobarroca, esta publicación implica un gesto político nacionalista: en el contexto de la sangrienta dictadura de François Duvalier, Alexis exalta el ámbito rural y lo considera un arma poderosa para defender la identidad nacional frente a la cultura imperialista extranjera, que avanza auspiciada por el régimen duvalierista.
Pola konsumsi makanan tinggi natrium, status gizi, dan tekanan darah pada pasien hipertensi di Puskesmas Mantok, Kabupaten Banggai, Sulawesi Tengah
Authors: Mantuges Sri Hartati , Widiany Fery Lusviana , Astuti Ari Tri 
Published: March 2021

Latar Belakang: Provinsi Sulawesi Tengah, secara nasional menempati peringkat ke─8 tertinggi untuk prevalensi hipertensi berdasarkan diagnosis dokter atau konsumsi obat antihipertensi pada penduduk usia ≥18 tahun. Prevalensi obesitas di provinsi tersebut lebih tinggi daripada rata-rata prevalensi obesitas nasional, yaitu 21,8%. Wilayah kerja Puskesmas Mantok merupakan daerah pesisir dan sebagian besar penduduknya mengonsumsi produk olahan laut. Pola makan masyarakat dan status gizi diduga menjadi faktor penyebab hipertensi di wilayah tersebut. Tujuan: Untuk mengetahui hubungan antara pola konsumsi makanan tinggi natrium dan status gizi dengan tekanan darah pada pasien hipertensi. Metode: Penelitian ini merupakan penelitian observasional dengan desain cross sectional, dilaksanakan di Puskesmas Mantok, Kabupaten Banggai. Subjek penelitian 48 pasien yang baru didiagnosis hipertensi dan diambil dengan teknik purposive sampling. Variabel bebas adalah pola konsumsi makanan tinggi natrium dan status gizi, variabel terikatnya tekanan darah. Data dianalisis dengan uji Chi Square. Hasil: Sebanyak 64,6% subjek mengonsumsi makanan tinggi natrium dengan kategori asupan lebih, sebagian besar subjek berstatus gizi lebih (58%) dan mengalami hipertensi grade II (67%). Analisis statistik menunjukkan adanya hubungan antara pola konsumsi makanan tinggi natrium dengan tekanan darah (p=0,033), dan ada hubungan antara status gizi dengan tekanan darah (p=0,025). Kesimpulan: Pola konsumsi makanan tinggi natrium dan status gizi berhubungan dengan tekanan darah pada pasien hipertensi di Puskesmas Mantok, Kabupaten Banggai, Sulawesi Tengah, Indonesia.
Durasi tidur dan aktivitas sedentari sebagai faktor risiko hipertensi obesitik pada remaja
Authors: Oematan Grouse , Oematan Gustaf 
Published: March 2021

Latar Belakang: Hipertensi obesitik adalah suatu kondisi hipertensi yang didahului oleh obesitas. Prevalensi hipertensi obesitik pada remaja diperkirakan akan terus meningkat. Hal ini akan berdampak buruk pada kesehatan remaja saat dewasa. Durasi tidur dan aktivitas sedentari dianggap sebagai salah satu faktor yang berkontribusi terhadap timbulnya hipertensi obesitik pada remaja. Tujuan: Penelitian ini bertujuan untuk mengetahui apakah durasi tidur pendek dan aktivitas sedentari sebagai faktor risiko hipertensi obesitik pada remaja. Metode: Penelitian ini menggunakan metode kuantitatif dengan desain case-control.Subjek dalam penelitian ini adalah 168 siswa sekolah menengah pertama di Kecamatan Pamulang, terdiri dari 84 siswa obesitas dengan hipertensi sebagai kasus dan 84 siswa obesitas tanpa hipertensi sebagai kontrol. Data durasi tidur diambil menggunakan Sleep Clinic Questionnaire, data aktivitas sedentari diambil dengan menggunakan ASAQ (Adolescents Sedentary Activity Questionnaire). Hasil: Penelitian ini menemukan hubungan antara durasi tidur pendek (p<0,001) dan aktivitas sedentari (p<0,05) dengan hipertensi obesitik. Remaja dengan durasi tidur yang kurang dari 8 jam per hari berisiko 5,48 kali untuk mengalami hipertensi obesitik. Sementara itu remaja dengan aktivitas sedentari lebih dari 6 jam per hari memiliki risiko 2,27 kali untuk mengalami hipertensi obesitik. Kesimpulan: Durasi tidur pendek dan aktivitas sedentari adalah faktor risiko hipertensi obesitik pada remaja.
WORKSHOP PENGGUNAAN APLIKASI JOGJA SMART SERVICE SEBAGAI UPAYA MEMPERCEPAT AKSES BANTUAN PADA PERISTIWA BENCANA, KECELAKAAN DAN TINDAK KEKERASAN DI KAMPUNG KEPUH KELURAHAN KLITREN KECAMATAN GONDOKUSUMAN
Authors: Erizal Erizal , Listiawan Indra 
Published: March 2021

Kampung Kepuh is located in a geographic position -7781984, 110184. Kelurahan Klitren has a population of 9669 inhabitants, with a male gender distribution of 4719 people and 4950 women. The area of Kepuh village, which is located in Klitren village, is adjacent to Jalan Solo, which is the second center of shops in Jogjakarta. This condition causes Kepuh village to have the potential for disasters such as fires, prone to traffic accidents and prone to acts of violence such as thieves, pickpockets and robbery. Therefore, it requires easy access to seek assistance for the people of Kepuh village. One access to seeking assistance is the Jogja Smart Service application which can be installed on a cellphone or smartphone. The problem is that the use of cellphones has not been optimal in terms of accessing services for requests for assistance to the city government through the Jogja Smart Service (JSS) application. The solution given was a short workshop with classical and face-to-face methods on the use of the JSS application Keywords: Disaster-prone, Jogja Smart Service, workshop with a coma
PENYULUHAN TENTANG COVID-19 DENGAN PEMANFAATAN MEDIA POSTER PADA MASYARAKAT DI DESA MANGUNREJO
Authors: Ratnawati Riska , D Afifah Nur , Andini Anggie Nur , Indrasena Bangkit 
Published: March 2021

The high incidence of the spread of the covid-19 virus has caused very high fear for the entire world community, especially those of us who live in Indonesia, the Corona Virus, which we know as Covid-19, was first discovered in Wuhan China, at the end of December 2019. Covid disease -19 is most contagious when the person suffering from it has symptoms, although the spread may occur before symptoms appear (Rothan, 2020). Covid-19 cases in Indonesia have increased every day based on data obtained from Deti Mega Purnamasari through kompas.com until April 15, 2020, there were 5,136 positive cases of covid-19. The positive number of Covid-19 in East Java, especially Magetan Regency, continues to increase. Magetan Regency is in 30th place compared to other districts / cities in East Java with an upward trend in the epidemic. Almost all areas in Magetan Regency have contracted this virus, one of which is Desa Mangunrejo, Kawedanan District, Magetan Regency. The purpose of this community service activity is to provide knowledge about how to prevent the spread of the covid-19 virus for the general public, especially in Mangunrejo Village. The method of implementing this community service is providing health education about symptoms, ways of transmission and prevention of Covid-19. The result increases the knowledge of the people of Mangunrejo Village, Magetan Regency. Keywords: Counseling, Covid-19, Poster
Кисломолочный продукт на растительной основе
Authors: Донская Галина Андреевна , Дрожжин Виктор Михайлович , Блинова Татьяна Евгеньевна , Семипятный Владислав Константинович 
Published: March 2021

Проведен сравнительный анализ процессов сквашивания соевого напитка и коровьего молока ацидофильной молочнокислой палочкой штамма ВНИМИ Bact.acidophilum АК – 97. Показано, что процесс кислотообразования в коровьем молоке проходит значительно быстрее в сравнении с соевым напитком. Продолжительность сквашивания коровьего молока составляет 3 часа, соевого напитка – 24 часа. Активность клеток ацидофильной молочнокислой палочки в соевом напитке ниже чем в коровьем молоке. Можно предположить, что деление клеток в соевом напитке не подчиняется закону геометрической прогрессии. Выживаемость клеток в обоих сквашенных продуктах снижается во времени. На 26-е сутки хранения количество клеток составляло 0,66х107 – в соевом напитке и 1,5х108 - в коровьем молоке. Форма и расположение клеток ацидофильной молочнокислой палочки, показанные при микроскопировании, идентичны в обоих видах продуктов. Исключение составляло поле соевого напитка в первые сутки после сквашивания. В нём отмечали крупные тёмные шарообразные включения, которые исчезали на 21-е сутки. Изучено влияние ацидофильной палочки на характер изменения антиоксидантной активности соевого напитка. Суммарное содержание водорастворимых антиоксидантов в соевом продукте превосходит сквашенное коровье молоко и соответствует значению 7,8±0,6 мг/100 г. В процессе сквашивания антиоксидантная активность соевого продукта возрастает до 8,9±2,04 мг/100 г. Изучены органолептические показатели сквашенного соевого продукта в период хранения. На 20-е сутки сгусток приобретает рыхлую консистенцию, продукт имеет нетоварный вид и неудовлетворительный вкус с выраженным растительным запахом.
The Relationship of Hope with Life Satisfaction through the Path of Resilience
Authors: Zia Ur Rehman  , Abdul Khaliq Alvi  , Zaeem Ahmad  
Published: March 2021

This research aims to check the mediating role of resilience between the relationships of hope with life satisfaction. Hope and mindfulness are independent variables and life satisfaction is the dependent variable. This is cross-sectional research and data was collected from 350 employees of an engineering company randomly. Simple linear and multiple regression analyses are performed for testing the hypotheses of the study. Results indicate that hope has a direct positive impact on life satisfaction and resilience respectively. Moreover, resilience is partially mediating the relationship of hope with life satisfaction. The current study considers only the employees of Mott MacDonald Group. Current research is a case study on Mott MacDonald Group, so cannot generalize the results on other types of industry and describes only a few predictors of life satisfaction. Future researches will also conduct on the same kind of engineering firm for generalization. In future researches, some other variables as predictors and outcomes may also include for explaining the phenomenon of life satisfaction. It is also beneficial to conduct this kind of research on sectors like the textile sector, banking sector, and telecom sector. Life satisfaction is very supportive for the organizations to maintain balance in work and lives of employees which may result in dedicated employees. The proposed research model of life satisfaction is satisfactorily supported by empirical tests.
Penerapan Model Pembelajaran Realistic Mathematics Education (RME) Terhadap Kemampuan Pemahaman Konsep Matematis Siswa
Authors: Sastia Reta 
Published: March 2021

Penelitian ini bertujuan untuk melihat adanya pengaruh pendekatan matematika realistik terhadap kemampuan pemahaman konsep matematika siswa kelas VIII SMP pada materi prisma. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif dengan jenis penelitian studi kepustakaan. Dari hasil tersebut dapat disimpulkan bahwa penggunaan model pendekatan Realisik Matematika Education (RME) berpengaruh positif terhadap kemampuan pemahaman konsep matematika, hal ini disebabkan karena dalam penerapan model pembelajaran tersebut (1) Siswa dapat membangun sendiri pengetahuannya sehingga siswa dapat lebih mudah memahami konsep dan tidak mudah lupa dengan pengetahuannya, (2) Siswa diberikan permasalahan matematika yang berkaitan dengan permasalahan kehidupan sehari-hari mereka, (3) Kegiatan di dalam kelas pada saat proses belajar menarik dan juga menyenangkan oleh sebab itu siswa lebih cepat memahami konsep dan tidak cepat bosan untuk belajar matematika