bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mielorradiculopatia esquistossomótica
Authors: Brandão Lívia Helena Gomes de Barros , Cavalcanti Camila Neves de Melo , Fachin Laércio Pol , Moura Adriana Ávila , Pires Ana Carolina de Carvalho Ruela 
Published: December 2021

A esquistossomose é uma endemia parasitária típica das Américas, Ásia e África. A Mielorradiculopatia Esquistossomótica surge como uma evolução severa da infecção por esquistossomose e, apesar de muito comum, sua prevalência em áreas endêmicas vem sendo subestimada. Objetivo: relatar caso de Mielorradiculopatia Esquistossomótica ocorrido em paciente pediátrico. Metodologia: estudo descritivo do tipo Relato de Caso retrospectivo, submetido e aprovado pelo Comitê de Ética em Pesquisa do Centro Universitário CESMAC, CAAE: 28835220.0.0000.0039, N.º do Parecer: 3.898.292. Relato de caso: paciente do sexo masculino, previamente hígido, 11 anos, iniciou quadro com história álgica aguda em membros inferiores que piorava no período da noite acompanhada de relato de febre. Quadro clínico evoluiu com lombalgia, disúria, oligúria, posterior anúria e formação de globo vesical. Evoluiu, também, com paresia de membros inferiores. A investigação realizou-se com Exame Parasitológico de Fezes positivo para esquistossomose, além de Ressonância Magnética de coluna lombo-sacra que corroboraram com a hipótese diagnóstica. Instituiu-se tratamento com Albendazol, Praziquantel e pulsoterapia com Metilprednisolona durante internação. Paciente teve alta hospitalar com melhora de quadro neurológico, em uso de prednisona 40 mg/dia. Conclusão: a MRE constitui a forma mais grave dentre as manifestações ectópicas da esquistossomose. A dificuldade do reconhecimento do quadro clínico e a limitação no acesso aos métodos complementares diagnósticos contribuem para o subdiagnóstico da enfermidade, acarretando sequelas graves para os portadores da doença e ocultando sua importância epidemiológica principalmente em pacientes pediátricos e jovens.
Nevo epidérmico verrucoso inflamatório linear e diagnóstico diferencial com a psoríase linear
Authors: Zemero Maria Isabel Muniz , Santos Maria Amélia Lopes dos , Mendes Alena Margareth Darwich , Pires Carla Andrea Avelar 
Published: December 2021

O nevo epidérmico verrucoso inflamatório linear (NEVIL) é uma variedade clínica rara de nevo epidérmico verrucoso, que se manifesta no início da infância, como lesões inflamatórias de superfície ceratósica, que coalescem e se distribuem em faixa, acompanhando as linhas de Blaschko. Faz diagnóstico diferencial com a psoríase linear, sendo difícil a diferenciação, dado os aspectos clínicos e histopatológicos comuns aos dois, enfantizando-se a necessidade de conhecer as características específicas de cada um. O objetivo deste relato é demonstrar uma afecção relativamente rara, descrita em uma menina de 5 anos, evoluindo desde os primeiros dias de vida com placas papuloceratósicas dispostas linearmente, acompanhadas de sinais inflamatórios e áreas erosadas ocupando grandes lábios, períneo e face interna e superior da coxa esquerda. Também pápulas e placas ceratósicas na região cervical posterior e borda lateral externa da planta do pé esquerdo, ascendendo ao longo da região posterior deste membro. Os critérios clínicos e histopatológicos corroboram o diagnóstico de NEVIL na diferenciação com a psoríase linear, ressaltando a importância do estabelecimento de critérios/ ferramentas que auxiliem na diferenciação destas duas dermatoses visando agilizar o diagnóstico, otimizar o tratamento e minimizar o desconforto para esses pacientes. O acompanhamento a longo prazo dos portadores é sugerido pela possibilidade ainda que mínima de malignização do NEVIL.
Behavioral Prioritization Enhances Working Memory Precision and Neural Population Gain
Authors: Yoo Aspen H. , Bolaños Alfredo , Hallenbeck Grace E. , Rahmati Masih , Sprague Thomas C. , Curtis Clayton E. 
Published: December 2021

Abstract
Humans allocate visual working memory (WM) resource according to behavioral relevance, resulting in more precise memories for more important items. Theoretically, items may be maintained by feature-tuned neural populations, where the relative gain of the populations encoding each item determines precision. To test this hypothesis, we compared the amplitudes of delay period activity in the different parts of retinotopic maps representing each of several WM items, predicting the amplitudes would track behavioral priority. Using fMRI, we scanned participants while they remembered the location of multiple items over a WM delay and then reported the location of one probed item using a memory-guided saccade. Importantly, items were not equally probable to be probed (0.6, 0.3, 0.1, 0.0), which was indicated with a precue. We analyzed fMRI activity in 10 visual field maps in occipital, parietal, and frontal cortex known to be important for visual WM. In early visual cortex, but not association cortex, the amplitude of BOLD activation within voxels corresponding to the retinotopic location of visual WM items increased with the priority of the item. Interestingly, these results were contrasted with a common finding that higher-level brain regions had greater delay period activity, demonstrating a dissociation between the absolute amount of activity in a brain area and the activity of different spatially selective populations within it. These results suggest that the distribution of WM resources according to priority sculpts the relative gains of neural populations that encode items, offering a neural mechanism for how prioritization impacts memory precision.
How Working Memory and Reinforcement Learning Are Intertwined: A Cognitive, Neural, and Computational Perspective
Authors: Yoo Aspen H. , Collins Anne G. E. 
Published: December 2021

Abstract
Reinforcement learning and working memory are two core processes of human cognition and are often considered cognitively, neuroscientifically, and algorithmically distinct. Here, we show that the brain networks that support them actually overlap significantly and that they are less distinct cognitive processes than often assumed. We review literature demonstrating the benefits of considering each process to explain properties of the other and highlight recent work investigating their more complex interactions. We discuss how future research in both computational and cognitive sciences can benefit from one another, suggesting that a key missing piece for artificial agents to learn to behave with more human-like efficiency is taking working memory's role in learning seriously. This review highlights the risks of neglecting the interplay between different processes when studying human behavior (in particular when considering individual differences). We emphasize the importance of investigating these dynamics to build a comprehensive understanding of human cognition.
Paul among the Fluent in Corinth
Authors: Last Richard 
Published: December 2021

Abstract
This article foregrounds the importance of Paul’s letters for studying the experiences and perceptions of persons who stutter in antiquity. It analyzes Paul’s speech alongside the biographies of two other historical figures from antiquity who suffered from speech dysfluency: the great Athenian orator, Demosthenes, and the emperor Claudius. Accounts of Demosthenes’, Claudius’, and Paul’s speech inconsistencies, silences, incomprehensible utterances, oratory weaknesses—and their critics’ accusations that they suffered from madness—are interpreted in light of research on adults who stutter in the contemporary context, as well as studies on listener experiences and stereotypes. In introducing Paul into the study of ancient dysfluency, the article revisits Paul’s conflict with rival teachers in Corinth as it is in responding to these critics’ accusations that Paul is most revealing of his own dysfluency.
The Meaning of a Matthean Redaction
Authors: Blackburn Barry L. 
Published: December 2021

Abstract
In Matt 26:64 the evangelist redacts Mark 14:62 by adding the phrase ἀπ’ ἄρτι prior to Mark’s ὄψεσθε τὸν υἱὸν τοῦ ἀνθρώπου ἐξ δεξιῶν καθήµενον τῆς δυνάµεως καὶ ἐρχόµενον µετὰ τῶν νεφελῶν τoῦ οὐρανοῦ. The present study attempts to demonstrate (1) that this addition does not negate a reference to the parousia, as argued, inter alios, by John P. Meier and R.T. France, and (2) that ἀπ’ ἄρτι in Matt 26:64 functions to draw a sharp contrast between the humiliation of Jesus’ passion and his glorious parousia, which would happen in the near future.
South Sudan
Authors: Jok Jok Madut 
Published: December 2021

Abstract
When South Sudan gained independence in 2011, the whole world rejoiced. The country marked 10 years of independence on July 9, 2021, but on that occasion, as was the case for the previous decade, its people had very little to celebrate. The country had been gripped by both state violence and deadly ethnic feuds. The intense rifts in ethnic relations emanating from this cycle have become a major risk factor for mass atrocities. This paper aims to chronicle the atrocity crimes that have happened in South Sudan in the past 12 years, what drives them, and how they can be mitigated or stopped. It will also suggest what the international community can do to assist the South Sudanese to find justice, accountability for atrocity crimes and above all, how to reduce or end violence. The paper is based on a review of reports by human rights agencies, the United Nations agencies operating in South Sudan, independent researchers, academics and think tanks. It is also based on the author’s first-hand knowledge of the context and on numerous interviews with South Sudanese. The goal, however, is not to ask: what lessons have been learned from the ongoing efforts in the country?
An Insider’s Response to Racism: Abe Fortas and the Japanese Question during the Asia-Pacific War, 1941–1945
Authors: Lee Seok-Won 
Published: December 2021

Abstract
Abe Fortas (1910–1982) has been best known for service during his legal career as an Associate Justice on the Supreme Court of the United States for four years from 1965 to 1969. His supporters have characterized his life as a lawyer who supported and defended the American Civil Rights Movement during the tumultuous periods of the 1950s and 1960s in the United States. However, observers of his career have paid little attention to the fact that Fortas was one of the few American bureaucrats who took the stand in defense of those of Japanese ancestry in the official hearings in the 1980sinvestigating the internment of Japanese Americans during World War ii. Fortas, as undersecretary in the Department of the Interior from 1942 to 1946, had a close relationship to key U.S. policies dealing with people of Japanese ancestry during the Asia-Pacific War, including the establishment of martial law in Hawai‘i and the ending of the Japanese internment. Fortas’s responses to and critiques of U.S. policy regarding the Japanese American question reveal the intertwined dynamics of how white racism developed and challenges against it at the governmental level.
Pharmacodynamics and molecular correlates of response to glofitamab in relapsed/refractory non-Hodgkin lymphoma
Authors: Bröske Ann-Marie E. , Korfi Koorosh , Belousov Anton , Wilson Sabine , Ooi Chia-Huey , Bolen Christopher R. , Canamero Marta , Alcaide Enrique Gomez , James Ian , Piccione Emily C. , Carlile David J. , Dimier Natalie , Umaña Pablo , Bacac Marina , Weisser Martin , Dickinson Michael 
Published: December 2021

Abstract
Glofitamab, a novel CD20xCD3, T-cell–engaging bispecific antibody, exhibited single-agent activity in Study NP30179, a first-in-human, phase 1 trial in relapsed/refractory B-cell non-Hodgkin lymphoma. Preclinical studies showed that glofitamab leads to T-cell activation, proliferation, and tumor cell killing upon binding to CD20 on malignant cells. Here, we provide evidence of glofitamab’s clinical activity, including pharmacodynamic profile, mode of action, and factors associated with clinical response, by evaluating biomarkers in patient samples from the dose-escalation part of this trial. Patients enrolled in Study NP30179 received single-dose obinutuzumab pretreatment (1000 mg) 7 days before IV glofitamab (5 µg-25 mg). Glofitamab treatment lasted ≤12 cycles once every 2 or 3 weeks. Blood samples were collected at predefined time points per the clinical protocol; T-cell populations were evaluated centrally by flow cytometry, and cytokine profiles were analyzed. Immunohistochemical and genomic biomarker analyses were performed on tumor biopsy samples. Pharmacodynamic modulation was observed with glofitamab treatment, including dose-dependent induction of cytokines, and T-cell margination, proliferation, and activation in peripheral blood. Gene expression analysis of pretreatment tumor biopsy samples indicated that tumor cell intrinsic factors such as TP53 signaling are associated with resistance to glofitamab, but they may also be interlinked with a diminished effector T-cell profile in resistant tumors and thus represent a poor prognostic factor per se. This integrative biomarker data analysis provides clinical evidence regarding glofitamab’s mode of action, supports optimal biological dose selection, and will further guide clinical development. This trial was registered at www.clinicaltrials.gov as #NCT03075696.
ERS/ATS technical standard on interpretive strategies for routine lung function tests
Authors: Stanojevic Sanja , Kaminsky David A. , Miller Martin R. , Thompson Bruce , Aliverti Andrea , Barjaktarevic Igor , Cooper Brendan G. , Culver Bruce , Derom Eric , Hall Graham L. , Hallstrand Teal S. , Leuppi Joerg D. , MacIntyre Neil , McCormack Meredith , Rosenfeld Margaret , Swenson Erik R. 
Published: December 2021

BackgroundAppropriate interpretation of pulmonary function tests (PFTs) involves the classification of observed values as within/outside the normal range based on a reference population of healthy individuals, integrating knowledge of physiological determinants of test results into functional classifications and integrating patterns with other clinical data to estimate prognosis. In 2005, the American Thoracic Society (ATS) and European Respiratory Society (ERS) jointly adopted technical standards for the interpretation of PFTs. We aimed to update the 2005 recommendations and incorporate evidence from recent literature to establish new standards for PFT interpretation.MethodsThis technical standards document was developed by an international joint Task Force, appointed by the ERS/ATS with multidisciplinary expertise in conducting and interpreting PFTs and developing international standards. A comprehensive literature review was conducted and published evidence was reviewed.ResultsRecommendations for the choice of reference equations and limits of normal of the healthy population to identify individuals with unusually low or high results are discussed. Interpretation strategies for bronchodilator responsiveness testing, limits of natural changes over time and severity are also updated. Interpretation of measurements made by spirometry, lung volumes and gas transfer are described as they relate to underlying pathophysiology with updated classification protocols of common impairments.ConclusionsInterpretation of PFTs must be complemented with clinical expertise and consideration of the inherent biological variability of the test and the uncertainty of the test result to ensure appropriate interpretation of an individual's lung function measurements.
Fine particulate matter components and interstitial lung disease in rheumatoid arthritis
Authors: Zhao Naizhuo , Al-Aly Ziyad , Zheng Boyang , van Donkelaar Aaron , Martin Randall V. , Pineau Christian A. , Bernatsky Sasha 
Published: December 2021

BackgroundExposure to ambient fine particulate matter with an aerodynamic diameter <2.5 μg·m−3(PM2.5) is a risk factor for pulmonary and systemic autoimmune diseases; however, evidence on which PM2.5chemical components are more harmful is still scant. Our goal is to investigate potential associations between major PM2.5components and interstitial lung disease (ILD) onset in rheumatoid arthritis (RA).MethodsNew-onset RA subjects identified from a US healthcare insurance database (MarketScan) were followed for new onset of RA-associated ILD (RA-ILD) from 2011 to 2018. Annual concentrations of ambient PM2.5chemical components (i.e.sulfate, nitrate, ammonium, organic matter, black carbon, mineral dust and sea salt) were estimated by combining satellite retrievals with chemical transport modelling and refined by geographically weighted regression. Exposures from 2006 up to 1 year before ILD onset or end of study were assigned to subjects based on their core-based statistical area or metropolitan division codes. A novel time-to-event quantile-based g (generalised)-computation approach was used to estimate potential associations between RA-ILD onset and the exposure mixture of all seven PM2.5chemical components adjusting for age, sex and prior chronic obstructive pulmonary disease (as a proxy for smoking).ResultsWe followed 280 516 new-onset RA patients and detected 2194 RA-ILD cases across 1 394 385 person-years. The adjusted hazard ratio for RA-ILD onset was 1.54 (95% CI 1.47–1.63) per every decile increase in all seven exposures. Ammonium, mineral dust and black carbon contributed more to ILD risk than the other PM2.5components.ConclusionExposure to components of PM2.5, particularly ammonium, increases ILD risk in RA.
Predicting in-hospital death in pneumonic COPD exacerbationviaBAP-65, CURB-65 and machine learning
Authors: Shiroshita Akihiro , Kimura Yuya , Shiba Hiroshi , Shirakawa Chigusa , Sato Kenya , Matsushita Shinya , Tomii Keisuke , Kataoka Yuki 
Published: December 2021

IntroductionThere is no established clinical prediction model for in-hospital death among patients with pneumonic COPD exacerbation. We aimed to externally validate BAP-65 and CURB-65 and to develop a new model based on the eXtreme Gradient Boosting (XGBoost) algorithm.MethodsThis multicentre cohort study included patients aged ≥40 years with pneumonic COPD exacerbation. The input data were age, sex, activities of daily living, mental status, systolic and diastolic blood pressure, respiratory rate, heart rate, peripheral blood eosinophil count and blood urea nitrogen. The primary outcome was in-hospital death. BAP-65 and CURB-65 underwent external validation using the area under the receiver operating characteristic curve (AUROC) in the whole dataset. We used XGBoost to develop a new prediction model. We compared the AUROCs of XGBoost with that of BAP-65 and CURB-65 in the test dataset using bootstrap sampling.ResultsWe included 1190 patients with pneumonic COPD exacerbation. The in-hospital mortality was 7% (88 out of 1190). In the external validation of BAP-65 and CURB-65, the AUROCs (95% confidence interval) of BAP-65 and CURB-65 were 0.69 (0.66–0.72) and 0.69 (0.66–0.72), respectively. XGBoost showed an AUROC of 0.71 (0.62–0.81) in the test dataset. There was no significant difference in the AUROCs of XGBoostversusBAP-65 (absolute difference 0.054; 95% CI −0.057–0.16) orversusCURB-65 (absolute difference 0.0021; 95% CI −0.091–0.088).ConclusionBAP-65, CURB-65 and XGBoost showed low predictive performance for in-hospital death in pneumonic COPD exacerbation. Further large-scale studies including more variables are warranted.
Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study
Authors: Benz Elizabeth , Wijnant Sara R.A. , Trajanoska Katerina , Arinze Johnmary T. , de Roos Emmely W. , de Ridder Maria , Williams Ross , van Rooij Frank , Verhamme Katia M.C. , Ikram M. Arfan , Stricker Bruno H. , Rivadeneira Fernando , Lahousse Lies , Brusselle Guy G. 
Published: December 2021

BackgroundIncreasing evidence suggests that sarcopenia and a higher systemic immune-inflammation index (SII) are linked with morbidity in patients with COPD. However, whether these two conditions contribute to all-cause mortality in middle-aged and older patients with COPD or asthma is unclear. Therefore, we investigated the association between sarcopenia, SII, COPD or asthma and all-cause mortality in a large-scale population-based setting.MethodsBetween 2009 and 2014, 4482 participants (aged >55 years; 57.3% female) from the population-based Rotterdam Study were included. COPD and asthma patients were diagnosed clinically and based on spirometry. Six study groups were defined according to the presence or absence of COPD or asthma and sarcopenia. Cox regression models were used to assess all-cause mortality in the study groups, adjusted for sex, age, body mass index, SII, smoking, oral corticosteroid use and comorbidities. In addition, all participants were categorised into sex-specific quartiles of SII, and mortality in these groups was compared.ResultsOver a median follow-up of 6.1 years (interquartile range 5.0–7.2 years), 466 (10.4%) persons died. Independent of the presence of sarcopenia, participants with COPD had a higher risk of all-cause mortality (hazard ratio (HR) 2.13, 95% CI 1.46–3.12 and HR 1.70, 95% CI 1.32–2.18 for those with and without sarcopenia, respectively). Compared to lower SII levels, higher SII levels increased mortality risk even in people without sarcopenia, COPD or asthma.ConclusionMiddle-aged and older people with COPD, higher SII levels or sarcopenia had an independently increased mortality risk. Our study suggests prognostic usefulness of routinely evaluating sarcopenia and SII in older people with COPD or asthma.
Delayed-onset post-operative keratitis and endophthalmitis caused by Exophiala oligosperma
Authors: van der Merwe Laurie W. , da Costa Dawood , Reddy Kessendri , Meyer David 
Published: December 2021

AbstractA case of delayed-onset post-cataract-surgery keratitis and endophthalmitis, caused by the melanin-producing fungus Exophiala oligosperma, is presented. The patient presented with an infection at the corneal side-port wound 5 months after an uneventful phacoemulsification surgery. Despite pars plana vitrectomy and combination antifungal treatment, the patient required an evisceration of the globe. Limited clinical information is available about the treatment of eye infections caused by this organism.