bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-channel NIR/SWIR Lanthanide Nanoprobe for Forensic Gender Identification of Fingerprints
Authors: Liu Yuxin , Wei Zheng , Zhu Xingjun , Li Luoyuan , Ma Liyi , Zhou Jing 
Published: April 2021

Abstract
Fingerprints play vital roles in modern forensic investigations by providing essential personal information. To maximize the efficiency of forensic investigations, highly efficacious protocols are urgently needed for fingerprint capture and information extraction. Herein, a novel L-amino acids (L-AA)-responsive nanoprobe was rationally designed and constructed with orthogonal near-infrared (NIR) and short wave infrared (SWIR) emissions. Due to the difference in L-AA content in fingerprints between males and females, effective gender identification is also practicable by analysing the NIR/SWIR luminescence ratio. More importantly, by utilizing adhesive L-AA on latent fingerprints as a target, simultaneous washing-free NIR/SWIR ratiometric luminescence imaging and forensic gender identification of latent fingerprints are achieved with not only high spatial resolution but advanced precision. Our findings provide a new strategy for the development of a new generation of nanoprobes for simple washing-free fingerprint imaging and valid forensic gender identification.
Antibody response to BTN162b2 mRNA vaccination in naïve versus SARS-CoV-2 infected subjects with and without waning immunity
Authors: Carbonare Luca Dalle , Valenti Maria Teresa , Bisoffi Zeno , Piubelli Chiara , Pizzato Massimo , Accordini Silvia , Mariotto Sara , Ferrari Sergio , Minoia Arianna , Bertacco Jessica , Vigni Veronica Li , Dorelli Gianluigi , Crisafulli Ernesto , Alberti Daniela , Masin Laura , Longoni Silvia , Lopalco Lucia , Beretta Alberto , Tiberti Natalia , Zipeto Donato 
Published: April 2021

Abstract
We profiled antibody responses in a cohort of recipients of the BTN162b2 mRNA vaccine who were either immunologically naïve (n=50) or had been previously infected with SARS-CoV-2 (n=51). Of the previously infected, 25 and 26 were infected during the first and second pandemic waves in Italy, respectively; the majority of those from the first wave had corresponding waning immunity with low to undetectable levels of anti-S antibodies and low anti-N antibodies. We observed in recipients who had been previously infected that spike-specific IgG and pseudovirus neutralization titers were rapidly recalled by a single vaccine dose to higher levels than those in naïve recipients after the second vaccine dose, irrespective of waning immunity. In all recipients, a single vaccine dose was sufficient to induce a potent IgA response that was not associated with serum neutralization titers.
The Prognostic Significance of the Alterations of Cardiovascular Hemodynamics in Patients With Pulmonary Arterial Hypertension: A Meta-regression Analysis of Randomized Controlled Trials
Authors: Sung Shih-Hsien , Yeh Wan-Yu , Chiang Chern-En , Huang Chi-Jung , Huang Wei-Ming , Chen Chen-Huan , Cheng Hao-min 
Published: April 2021

Abstract
Background: Hemodynamic assessment in patients with pulmonary arterial hypertension (PAH) is essential for risk stratification and pharmacological management. However, the prognostic value of the hemodynamic changes after treatment is less well established. Objectives: We investigated the prognostic impacts of the changes in hemodynamic indices, including mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), right atrial pressure (RAP) and cardiac output index (CI). We conducted this systematic review with meta-regression analysis on existing clinical trials.Methods:We searched and identified all relevant randomized controlled trials from multiple databases. An analogous R2 index was used to quantify the proportion of variance explained by each predictor in the association with PAH patients’ prognosis. A total of 20 trials and 3,263 individuals were enrolled. Results:The changes in mPAP, PVR, RAP and CI were all significantly associated with the change in 6MWD (∆6MWD). The change in mPAP was with the highest explanatory power for ∆6MWD (R2 analog=0.739). Additionally, the changes in mPAP, PVR and CI were independently predictive of adverse clinical events. The change in mPAP had the highest explanatory power for the clinical events (R2 analog =0.911). Furthermore, the change in PVR was with the highest explanatory power for total mortality of PAH patients (R2 analog =0.594). Conclusion:Hemodynamic changes after treatment, including mPAP, PVR, CI and RAP, were significantly associated with adverse clinical events or mortality in treated PAH patients. It is recommended that further studies be conducted to evaluate the changes in hemodynamic indices to guide drug titration.Trial registration number: PROSPERO; No.: CRD42019125157; URL: https://www.crd.york.ac.uk/PROSPERO/ (Date of registration: 14/03/2019)
The COVID-19 Pandemic Drives People to Orthorexia and Anxiety with the Influence of Social Media: A Cross-Sectional Study of 525 Adults in Semi-Quarantine
Authors: Devrim-Lanpir Asli , Güzeldere Hatice Kübra Barcın , Çintesun Elif Ede 
Published: April 2021

Abstract
Background

The COVID-19 pandemic hit the world tremendously, causing an increased risk of eating and anxiety disorders. Increased social media exposure and obsession with healthy eating to minimize the risk of catching the COVID-19 may cause orthorexia and anxiety symptoms in individuals during pandemic. We aimed to assess the presence and interaction between orthorexia and anxiety symptoms during the first phase of the COVID-19 pandemic. We also determined the influences of social media and nutritional supplement use on orthorexic and anxiety symptoms.
Methods

We performed an online survey of individuals in COVID-19 quarantine (n = 525) using Google forms. We determined their orthorexia and anxiety symptoms using ORTO-11 and General Anxiety Disorder (GAD-7) questionnaire, respectively. We also assessed their nutritional supplement and social media use, and how these patterns were affected during the first phase of the COVID-19 pandemic.
Results

Higher orthorexia (67% in men, 83.2% in women) and anxiety (62.4% in men; 95.4% in women) symptoms were detected in individuals in COVID-19 pandemic. Orthorexia symptoms were found positively associated with anxiety symptoms in both sexes. The time spent on social media to follow the COVID-19, health, and nutrition news were closely associated with higher orthorexic symptoms in both sexes, and higher anxiety symptoms in women (r=-0.638 in men; r=-0.560 in women, p < 0.001). The use of multivitamins and ß-glucan to mainly support immunity were linked to orthorexic symptoms in both sexes.
Discussion

The COVID-19 pandemic has detrimental influences on mental well-being that drove individuals into psychologic problems. Increased social media use to follow healthy eating news has also create an undesirable impact on orthorexic problems. Therefore, it is crucial to detect orthorexia and anxiety symptoms earlier and modulate daily behaviours during the pandemic in order to prevent long-term detrimental consequences.
Time-to-recovery After Cesarean Section Delivery Among Women who Gave birth through Cesarean Section at Hawassa University Comprehensive Specialized Hospital, south Ethiopia: A Prospective Cohort Study
Authors: Fikrie Anteneh , Zeleke Rahel , Bekele Henok , Seyoum Wengelawit , Hailu Dejene 
Published: April 2021

Abstract
Background: Despite the progressive increment of caesarean section rates worldwide over the last decades; still the trend has not been accompanied by significant maternal or perinatal benefits. Moreover, information on the quality of the service, as measured by timely recovery, is scarce. This study assessed predictors of time-to-recovery after cesarean section delivery among women who gave birth through cesarean section at Hawassa University Comprehensive Specialized Hospital (HU-CSH), southern Ethiopia.Methods: Institution based prospective cohort study was conducted on 381 randomly selected women who gave birth by cesarean section in HU-CSH during the follow up period. Pre-tested structured questionnaire was used to collect the data. Data were analyzed using Kaplan Meir (KM) curve, Log rank test and Cox-Proportional hazard model. The outputs of the bivariable and multivariable Cox model are presented using Adjusted Hazard Ratio (AHR) with the respective 95% confidence intervals (CIs).Results: After a maximum of 19 days of stay, 96.2% [95%CI: 94.04-98.4%] of the women were early recovered. The overall median IQR) time of recovery was 2.00 (2, 3) days. The overall incidence density rate (IDR) of recovery in the cohort was 0.34 per Person-days or 2.38 per person-week. On the other hand the overall mean survival time was 3.07(95%CI: 2.75-3.40) days. Women who had ANC follow-up (AHR=1.49, 95%, CI: 1.05-2.10) and discharge from the wound site (AHR=0.13, 95%, CI: 0.03-0.56) were identified as significant positive and negative predictors of time-to- recovery after CS delivery respectively. Conclusion: This study showed that the rate of early recovery was high and is comparable to the global level figures. However, further improving preoperative maternal status, intraoperative follow up and post-operative care is needed to improve early recovery.
A mixed-methods study to determine the impact of COVID-19 on food security, food access and supply in regional Australia for consumers and food supply stakeholders.
Authors: Godrich Stephanie Louise , Lo Johnny , Kent Katherine , Macau Flavio , Devine Amanda 
Published: April 2021

Abstract
Background: The COVID-19 pandemic has impacted the Australian food supply through changed consumer purchasing patterns, and potentially, household food security. The aim of this study was to determine the impact of COVID-19 on the prevalence of food insecurity and food supply issues, and perspectives of food supply stakeholders in regional Australia. Methods: A mixed-methods consumer survey and in-depth interviews with food supply stakeholders were conducted in South West Western Australia between May and July 2020, immediately after the 1st wave of the pandemicResults: The prevalence of food insecurity was 21%, and significantly more prevalent for those aged less than 30 years and living with a disability. Most consumers (73%) agreed that the COVID-19 pandemic had impacted the food supply. Food insecure respondents were more likely to report that food was more expensive, resulting in changes to the types and quantities of food bought. Food supply stakeholders perceived that consumers increased their intention to buying locally grown produce. Panic buying temporarily reduced the availability of food for both consumers and food suppliers.Conclusions: Further government support at a local, regional, and national level is necessary to support households at risk of food insecurity and to bolster regional food systems to support equitable access to food.
Developing a Patient-Centered Community-Based Model for Management of Multi-Drug Resistant Tuberculosis in Uganda: A Mixed Methods Study
Authors: Makabayi-Mugabe Rita , Musaazi Joseph , Zawedde-Muyanja Stella , Kizito Enock , Namwanje Hellen , Aleu Philip , Charlet Danielle , Lopez Debora B. Freitas , Brightman Haley , Turyahabwe Stavia , Nkolo Abel 
Published: April 2021

Abstract
Background: The advent of all-oral regimens for the management of multi-drug resistant tuberculosis (MDR-TB) makes the implementation of community-based directly observed therapy (CB-DOT) a possibility for this group of patients. We set out to determine patient preferences for different attributes of a community-based model for the management of MDR-TB in Uganda. Methods: The study was conducted at five tertiary referral hospitals. We used a parallel convergent mixed methods study design. To collect quantitative data, we conducted a discrete choice experiment (DCE) with three different attributes of community-based care (provider type, location of care, and type of support) combined into eight choice sets, each with two options and an opt-out. We collected additional qualitative data by eliciting patient reasons for selection of each choice set. We fitted a mixed logit choice model to determine patient preferences for different attributes of community-based care. Thematic analysis using NVivo12 was done to understand the reasons for the choices made. Results: From December 2019 to January 2020, we interviewed 103 patients with MDR-TB. Majority (58.3%) were male; 61.2% were HIV negative; and the median age was 37 (IQR 30-47) years. Two thirds (65.1%) earned less than $1 per day. Study participants preferred at least one of the CB-DOT models of care to none (current standard of care). The most preferred model consisted of a community health worker (CHW) giving DOT at home and travel vouchers to enable attendance at monthly clinic follow-up visits. Qualitative interviews revealed that patients perceived CHWs as knowledgeable and able to offer psychosocial support. Patients also indicated a preference for taking medication at home because it saves both time and money and presents a lower risk of being stigmatized. Conclusion: People with MDR-TB prefer to be supported to take their medicine at home by a member of their community. The effectiveness of this model of care will be further evaluated.
Observational and genetic evidence on the association of sleep behaviors with the incidence of fracture
Authors: Qian Yu , Jiangwei Xia , Liu Ke-Qi , Xu Lin , Xie Shu-Yang , Chen Guo-Bo , cong Pei-kuan , Saber Khederzadeh , Zheng Houfeng 
Published: April 2021

Abstract
Here, we combined conventional evidence from longitudinal data in UK Biobank and genetic evidence from Mendelian randomization (MR) approach to infer the causality between sleep behaviors and fracture risk. We found that participants with insomnia showed a 7.0% higher risk of fracture (hazard ratio [HR] = 1.070, 95%CI = 1.045–1.096, P = 1.87×10− 8), falls and BMD mediated 26% and 10% of the intermediary effect, the MR analyses provided the consistent evidence. A U-shape relationship was observed between sleep duration and fracture risk (P < 0.001) with the lowest fracture risk at sleeping 7–8 hours per day. The excessive daytime sleepiness and “evening” chronotype were associated with fracture risk in observational study, but the association between chronotype and fracture did not show in MR analyses. We further generated a sleep risk score (SRS) with potential risk factors (i.e., insomnia, sleep duration, chronotype, and daytime sleepiness). We found that the risk of fracture increased with an increasing SRS (HR = 1.095, 95%CI = 1.073–1.118, P < 2×10− 16). Moreover, 19.4% of the fracture cases would be removed if participants exhibited a healthy sleep pattern. In conclusion, insomnia had a causal effect on fracture, falls had a larger intermediary effect than BMD in this association. Individuals with fracture risk could benefit from the intervention on unhealthy sleep pattern.
Metformin Induces Ferroptosis byInhibiting UFMylation of SLC7A11 in Breast Cancer
Authors: Yang Jingjing , Zhou Yulu , Xie Shuduo , Wang Ji , Li Zhaoqing , Chen Lini , Mao Misha , Chen Cong , Huang Aihua , Chen Yongxia , Zhang Xun , KHAN NOOR UL HASSAN , Wang Linbo , Zhou Jichun 
Published: April 2021

Abstract
Background

Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis is considered to be a novel anti-cancer strategy. The identification of FDA-approved drugs as ferroptosis inducers is proposed to be a new promising approach for cancer treament. Despite a growing body of evidence indicating the potential efficacy of the anti-diabetic metformin as an anti-cancer agent, the exact mechanism underlying this efficacy has not yet been fully elucidated.
Methods

The UFMylation of SLC7A11 is detected by immunoprecipitation and the expression of UFM1 and SLC7A11 in tumor tissues was detected by immunohistochemical. The level of ferroptosis is determined by the level of free iron, total/lipid Ros and GSH in the cells and the morphological changes of mitochondria are observed by transmission electron microscope.The mechanism in vivo was verified by in situ implantation tumor model in nude mice.
Results

Metformin induces ferroptosis in an AMPK-independent manner to suppress tumor growth. Mechanistically, we demonstrate that metformin increases the intracellular Fe2+ and lipid ROS levels. Specifically, metformin reduces the protein stability of SLC7A11, which is a critical ferroptosis regulator, by inhibiting its UFMylation process. Furthermore, the combination of the system xc− inhibitor sulfasalazine and metformin can work in a synergistic manner to induced ferroptosis,which inhibits the proliferation of breast cancer.
Conclusions

This study is the first to demonstrate that the ability of metformin to induce ferroptosis may be a novel mechanism underlying its anti-cancer effect. In addition, we identified SLC7A11 as a new UFMylation substrate and found that targeting the UFM1/SLC7A11 pathway could be a promising cancer treatment strategy.
Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation
Authors: Cellat Mustafa , Kuzu Müslüm , İşler Cafer Tayer , Etyemez Muhammed , Dikmen Nursel , Uyar Ahmet , Gökçek İshak , Türk Erdinç , Güvenç Mehmet 
Published: April 2021

Abstract
Purpose
Asthma is an inflammatory disease that affects many people around the world, especially individuals of pediatric age. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA).
Methods
For this purpose, 4 groups, each consisting of 8 rats, were formed. Serum physiological was given to the control group for 21 days. OVA was given to OVA, OVA + Dexamethasone (Dexa) and OVA + tyrosol groups intraperitoneally and by inhalation. Additionally, 0.25 mg/kg Dexa was administered to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + Tyrosol group by oral gavage. Serum, blood, BALF fluid and lung tissues of the rats were examined.
Results
it was observed that the MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in the tyrosol treatment groups. It was also observed that NF-κB, TNF-α, IL-4, IL-5, IL-13, IFN-𝛾, and IgE levels decreased compared to the OVA group. However, no effect on IL-1 β level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level. The results of the histopathological investigation of lung tissue showed that tyrosol significantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was significantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased significantly.
Conclusions
The obtained results showed that tyrosol presented antioxidant and anti-inflammatory features on OVA-induced rats and preserved tissue architecture.
The Effectiveness Of Antibacterial Therapeutic Clothing Based On Silver Or Chitosan As Compared With Non-Antibacterial Therapeutic Clothing In Patients With Moderate To Severe Atopic Dermatitis (ABC Trial): Study Protocol For A Pragmatic Randomized Controlled Trial
Authors: Ragamin Aviël , Fieten Karin B. , Tupker Ron A. , de Wit Jill , Mierlo Minke M.F. van , Jansen Marieke , Bronner Madelon B. , Schappin Renske , Schuren Frank H.J. , Romeijn Margreet L.E. , Arents Bernd , Polinder Suzanne , de Graaf Marlies , Rustemeyer Thomas , Schuttelaar Marie-Louise S. , Pasmans Suzanne G.M.A. 
Published: April 2021

Abstract
Background:Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10% to 20% of children and between 2% and 15% of the adults in Western Europe. Since 2000 therapeutic clothing or functional textiles based on silver or chitosan as antibacterial agents were introduced for AD. These agents aim to reduce skin colonization with Staphylococcus (S.) aureus. Increased colonization with S. aureus is correlated with increased AD severity. The antimicrobial effects of silver and chitosan have been demonstrated before. At this point there is insufficient evidence for the effectiveness of antibacterial therapeutic clothing in patients with AD.Methods: This is a pragmatic randomized controlled double-blind multi-center trial comparing the effectiveness of antibacterial therapeutic clothing based on silver or chitosan as compared with non-antibacterial therapeutic clothing in patients with moderate to severe AD. A total of 165 participants, aged 0 to 80, diagnosed with moderate to severe AD are included. The study is performed in the Erasmus MC University Medical Center, University Medical Center Groningen, University Medical Center Utrecht, Amsterdam University Medical Centers and St. Antonius Hospital Nieuwegein. Patients will be randomized 1:1:1 into one of the three intervention groups: Group A will receive therapeutic clothing without antimicrobial agents, group B will receive microbial growth reducing therapeutic clothing based on chitosan, and group C will receive antimicrobial clothing based on silver. All therapeutic clothing is to be worn at night during the 12-month intervention period. Usual care is continued. The primary objective is to assess the effectiveness of antibacterial clothing (silver and chitosan group) as compared to non-antibacterial clothing assessed with the Eczema Area and Severity Index at 12 months compared to baseline. Secondary outcomes include between-group differences in physician and patient-reported outcome measures, topical therapy use, S. aureus skin colonization, and safety. Data will be collected at baseline, after 1 month, 3 months, 6 months an at 12 months. A cost-effectiveness analysis will be performed.Discussion:This trial will provide data on the effectiveness, cost-effectiveness, and safety of antibacterial therapeutic clothing for patients with AD. Trial registration Clinicaltrials.gov, NCT04297215. Registered on 5 March 2020
Distance to Highway and Factory Density Related to Lung Cancer Death and Associated Spatial Heterogeneity in Effects in Jiading District, Shanghai
Authors: Zhang Na , Wang Yingjian , Yu Hongjie , Zhang Yiying , Xiang Fang , Jiang Honglin , Zheng Yingyan , Xiong Ying , Wang Zhengzhong , Chen Yue , Jiang Qingwu , Shao Yueqin , Zhou Yibiao 
Published: April 2021

Abstract
Objective
This study aimed to explore distance to highway and factory density related to lung cancer (LC) death and their spatial heterogeneity in effect.
Methods
We conducted a retrospective cohort study by using the data of registered LC patients in Jiading District from 2002 to 2012. Standard parametric model with weibull distribution was used to explore factors related to LC death and the spatial effect of environmental factors were detected by using spatial survival analysis.
Results
Shorter distance to highway (aOR = 1.15, 95% CI:1.03–1.30) and higher factory density (aOR = 1.20, 95% CI:1.05–1.37) were significantly associated with increased risks of LC death, and the associations showed spatial differences in northern and southern areas of Jiading District, respectively. High-risk areas were mainly distributed in the suburbs with a low population density, while low-risk areas were primarily located in the urban areas.
Conclusion
Traffic and factory-related pollution was significantly associated with increased risk of LC death with an obvious spatial heterogeneity.