bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depressão como fator de risco para suicídio: Uma revisão sistemática
Authors: Furtado Igor Mendes , Medeiros Filho Osman Batista de 
Published: June 2021

Objetivo: Analisar a relação existente entre a depressão como fator de risco para o suicídio. Metodologia: Foi adotado o método de Revisão Sistemática da Literatura, cuja questão norteadora foi “Como a depressão influencia diretamente para o aumento das taxas de suicídio”? A temática da pesquisa foi buscada nas bases de dados Scientific Electronic Library Online (SCIELO) e na U. S. National Library of Medicine (PUBMED), da implantação dos Descritores em Ciências da Saúde (DeCS): (“suicide” AND “depression”). Os critérios de inclusão utilizados foram: presença dos DeCS, idioma português ou espanhol, texto completo disponível, estudos em humanos e estudos transversais. Após a aplicação dos filtros, apenas sete artigos se encaixaram nos critérios de elegibilidade. Resultados: Foi evidenciado através dos autores que as taxas da prática suicida relacionados à depressão têm aumentado de forma significativa, configurando-se em uma das principais causas de morte e problemas de saúde pública enfrentados na atualidade. Conclusão: Através desse estudo, foi revelado que as taxas de práticas suicidas relacionados a transtornos depressivos são notoriamente elevadas e que é necessário a existência de ferramentas científicas e econômicas para haver a prevenção dos casos de suicídios na esfera global.
Efficacy and Safety of Colchicine in Post–acute Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Diaz-Arocutipa Carlos , Benites-Meza Jerry K. , Chambergo-Michilot Diego , Barboza Joshuan J. , Pasupuleti Vinay , Bueno Héctor , Sambola Antonia , Hernandez Adrian V. 
Published: June 2021

Background: Inflammation plays a key role in atherosclerotic plaque destabilization and adverse cardiac remodeling. Recent evidence has shown a promising role of colchicine in patients with coronary artery disease. We evaluated the efficacy and safety of colchicine in post–acute myocardial infarction (MI) patients.Methods: We searched five electronic databases from inception to January 18, 2021, for randomized controlled trials (RCTs) evaluating colchicine in post–acute MI patients. Primary outcomes were cardiovascular mortality and recurrent MI. Secondary outcomes were all-cause mortality, stroke, urgent coronary revascularization, levels of follow-up high-sensitivity C-reactive protein (hs-CRP), and drug-related adverse events. All meta-analyses used inverse-variance random-effects models.Results: Six RCTs involving 6,005 patients were included. Colchicine did not significantly reduce cardiovascular mortality [risk ratio (RR), 0.91; 95% confidence interval (95% CI), 0.52–1.61; p = 0.64], recurrent MI (RR, 0.87; 95% CI, 0.62–1.22; p = 0.28), all-cause mortality (RR, 1.06; 95% CI, 0.61–1.85; p = 0.78), stroke (RR, 0.28; 95% CI, 0.07–1.09; p = 0.05), urgent coronary revascularization (RR, 0.46; 95% CI, 0.02–8.89; p = 0.19), or decreased levels of follow-up hs-CRP (mean difference, −1.95 mg/L; 95% CI, −12.88 to 8.98; p = 0.61) compared to the control group. There was no increase in any adverse events (RR, 0.97; 95% CI, 0.89–1.07; p = 0.34) or gastrointestinal adverse events (RR, 2.49; 95% CI, 0.48–12.99; p = 0.20). Subgroup analyses by colchicine dose (0.5 vs. 1 mg/day), time of follow-up (&lt;1 vs. ≥1 year), and treatment duration (≤30 vs. &gt;30 days) showed no changes in the overall findings.Conclusion: In post–acute MI patients, colchicine does not reduce cardiovascular or all-cause mortality, recurrent MI, or other cardiovascular outcomes. Also, colchicine did not increase drug-related adverse events.
SLC15A4 Serves as a Novel Prognostic Biomarker and Target for Lung Adenocarcinoma
Authors: Huang Hui , Wang Junwei , Chen Shibin , He HongJiang , Shang Yu , Guo Xiaorong , Lou Ge , Ji Jingjing , Guo Mian , Chen Hong , Yu Shan 
Published: June 2021

BackgroundSLC15A family members are known as electrogenic transporters that take up peptides into cells through the proton-motive force. Accumulating evidence indicates that aberrant expression of SLC15A family members may play crucial roles in tumorigenesis and tumor progression in various cancers, as they participate in tumor metabolism. However, the exact prognostic role of each member of the SLC15A family in human lung cancer has not yet been elucidated.Materials and MethodsWe investigated the SLC15A family members in lung cancer through accumulated data from TCGA and other available online databases by integrated bioinformatics analysis to reveal the prognostic value, potential clinical application and underlying molecular mechanisms of SLC15A family members in lung cancer.ResultsAlthough all family members exhibited an association with the clinical outcomes of patients with NSCLC, we found that none of them could be used for squamous cell carcinoma of the lung and that SLC15A2 and SLC15A4 could serve as biomarkers for lung adenocarcinoma. In addition, we further investigated SLC15A4-related genes and regulatory networks, revealing its core molecular pathways in lung adenocarcinoma. Moreover, the IHC staining pattern of SLC15A4 in lung adenocarcinoma may help clinicians predict clinical outcomes.ConclusionSLC15A4 could be used as a survival prediction biomarker for lung adenocarcinoma due to its potential role in cell division regulation. However, more studies including large patient cohorts are required to validate the clinical utility of SLC15A4 in lung adenocarcinoma.
Basic Spatiotemporal Gait Variables of Young and Older Healthy Volunteers Walking Along a Novel Figure-of-8 Path
Authors: Zancan Arturo , Sozzi Stefania , Schieppati Marco 
Published: June 2021

Background: Locomotion along curved trajectories requires fine coordination among body segments. Elderly people may adopt a cautious attitude when steering. A simple, expeditious, patient-friendly walking protocol can be a tool to help clinicians. We evaluated the feasibility of a procedure based upon a newly designed Figure-of-eight (nFo8) path and an easy measurement operation.Methods: Sixty healthy volunteers, aged from 20 to 86 years, walked three times at self-selected speed along a 20 m linear (LIN) and the 20 m nFo8 path. Number of steps, mean speed and walk ratio (step length/cadence) were collected. Data were analysed for the entire cohort and for the groups aged 20–45, 46–65, and &gt;65 years.Results: There was no difference in mean LIN walking speed between the two younger groups but the oldest was slower. During nFo8, all groups were slower (about 16%) than during LIN. Cadence was not different across groups but lower during nFo8 in each group. Step length was about 8% shorter in the two younger groups and 14% shorter in the oldest during nFo8 compared to LIN. Walk ratio was the smallest in the oldest group for both LIN and nFo8.Conclusions: A complex nFo8 walking path, with fast and easy measurement of a simple set of variables, detects significant differences with moderate and large effects in gait variables in people &gt;65 years. This challenging trajectory is more revealing than LIN. Further studies are needed to develop a quick clinical tool for assessment of gait conditions or outcome of rehabilitative treatments.
A Liquid-Liquid Phase Separation-Related Gene Signature as Prognostic Biomarker for Epithelial Ovarian Cancer
Authors: Qiu Yan , Pan Min , Chen Xuemei 
Published: June 2021

ObjectiveThe aim of the present study was to construct and test a liquid-liquid phase separation (LLPS)-related gene signature as a prognostic tool for epithelial ovarian cancer (EOC).Materials and MethodsThe data set GSE26712 was used to screen the differentially expressed LLPS-related genes. Functional enrichment analysis was performed to reveal the potential biological functions. GSE17260 and GSE32062 were combined as the discovery to construct an LLPS-related gene signature through a three-step analysis (univariate Cox, least absolute shrinkage and selection operator, and multivariate Cox analyses). The EOC data set from The Cancer Genome Atlas as the test set was used to test the LLPS-related gene signature.ResultsThe differentially expressed LLPS-related genes involved in several cancer-related pathways, such as MAPK signaling pathway, cell cycle, and DNA replication. Eleven genes were selected to construct the LLPS-related gene signature risk index as prognostic biomarker for EOC. The risk index could successfully divide patients with EOC into high- and low-risk groups. The patients in high-risk group had significantly shorter overall survival than those with in low-risk group. The LLPS-related gene signature was validated in the test set and may be an independent prognostic factor compared to routine clinical features.ConclusionWe constructed and validated an LLPS-related gene signature as a prognosis tool in EOC through integrated analysis of multiple data sets.
Impact of Previous Nephrectomy on Clinical Outcome of Metastatic Renal Carcinoma Treated With Immune-Oncology: A Real-World Study on Behalf of Meet-URO Group (MeetUro-7b)
Authors: Stellato Marco , Santini Daniele , Verzoni Elena , De Giorgi Ugo , Pantano Francesco , Casadei Chiara , Fornarini Giuseppe , Maruzzo Marco , Sbrana Andrea , Di Lorenzo Giuseppe , Soraru Mariella , Naglieri Emanuele , Buti Sebastiano , De Vivo Rocco , Napolitano Andrea , Vignani Francesca , Mucciarini Claudia , Grillone Francesco , Roviello Giandomenico , Di Napoli Marilena , Procopio Giuseppe 
Published: June 2021

BackgroundImmune-Oncology (IO) improves Overall Survival (OS) in metastatic Renal Cell Carcinoma (mRCC). The prognostic impact of previous Cytoreductive Nephrectomy (CN) and radical nephrectomy (RN), with curative intent, in patients treated with IO is not well defined. The aim of our paper is to evaluate the impact of previous nephrectomy on outcome of mRCC patients treated with IO.Methods287 eligible patients were retrospectively collected from 16 Italian referral centers adhering to the MeetUro association. Patients treated with IO as second and third line were included, whereas patients treated with IO as first line were excluded. Kaplan–Meier method and log-rank test were performed to compare Progression Free Survival (PFS) and OS between groups. In our analysis, both CN and RN were included. The association between nephrectomy and other variables was analyzed in univariate and multivariate setting using the Cox proportional hazard model.Results246/287 (85.7%) patients had nephrectomy before IO treatment. Median PFS in patients who underwent nephrectomy (246/287) was 4.8 months (95%CI 3.9–5.7) vs 3.7 months (95%CI 1.9–5.5) in patients who did not it (HR log rank 0.78; 95%CI 0.53 to 1.15; p = 0.186). Median OS in patients who had previous nephrectomy (246/287) was 20.9 months (95%CI 17.6–24.1) vs 13 months (95%CI 7.7–18.2) in patients who did not it (HR log rank 0.504; 95%CI 0.337 to 0.755; p = 0.001). In the multivariate model, nephrectomy showed a significant association with OS (HR log rank 0.638; 95%CI 0.416 to 0.980), whereas gland metastases were still associated with better outcome in terms of both OS (HR log rank 0.487; 95%CI 0.279 to 0.852) and PFS (HR log rank 0.646; 95%CI 0.435 to 0.958).ConclusionsIO treatment, in patients who had previously undergone nephrectomy, was associated with a better outcome in terms of OS. Further prospective trials would assess this issue in order to guide clinicians in real word practice.
A Systematic Review and Meta-Analysis of Randomized Controlled Trials With Novel Hormonal Therapies for Non-Metastatic Castration-Resistant Prostate Cancer: An Update From Mature Overall Survival Data
Authors: Maggi Martina , Salciccia Stefano , Del Giudice Francesco , Busetto Gian Maria , Falagario Ugo G. , Carrieri Giuseppe , Ferro Matteo , Porreca Angelo , Di Pierro Giovanni Battista , Fasulo Vittorio , Frantellizzi Viviana , De Vincentis Giuseppe , De Berardinis Ettore , Sciarra Alessandro 
Published: June 2021

IntroductionTo get better insight into the management of non-metastatic castration-resistant prostate cancer (M0 CRPC), in this meta-analysis and review we aimed to present an updated evaluation of the efficacy and safety of novel hormonal therapies (nHT) for M0 CRPC according to final analyses with mature overall survival (OS) and safety data.MethodsWe analyzed metastasis-free survival (MFS), OS, time to prostate-specific antigen (PSA) progression, second-line therapies data, adverse events (AEs), including all AEs, serious AEs (SAEs), AEs leading to discontinuation of trial regimen, AEs leading to death, fatigue, dizziness, cardiovascular events, and fractures; moreover, we evaluated the impact of PSA doubling time (PSA-DT), Eastern Cooperative Oncology Group (ECOG) score, use of bone-targeted therapy, lymph lodes (LN) status, and prior HT on final OS data. A comparison among the placebo arms of the included trials in terms of survival and safety profiles was assessed.ResultsAccording to the pooled analysis with updated and mature OS data, OS was significantly improved with nHT compared to placebo (hazard ratio (HR)= 0.74, 95% confidence interval (CI)= 0.66–0.84). nHT significantly improved OS over placebo across all pre-specified subgroups. Subgroup analysis revealed a greater OS benefit in patients with PSA-DT &gt;6 months than ≤6 months (HR= 0.69 versus HR= 0.75), ECOG 0 than 1 (HR= 0.70 versus HR= 0.80), N1 disease than N0 (HR= 0.61 versus HR= 0.78), and in those receiving bone-targeted therapy (HR= 0.65 versus HR= 0.74), and a comparable OS by number of prior HT (HR= 0.75 versus HR= 0.76, for HT= 1 and ≥2); yet, differences between pre-specified subgroups were not significant (all p&gt; 0.05). Overall, the nHT arm was significantly associated with higher rates of AEs, when compared with the placebo arm. The long-term analysis showed a worse safety profile with nHT than the interim analysis.ConclusionsAccording to final analyses, nHT have shown to improve OS over placebo in the setting of high-risk M0 CRPC. The long-term analysis showed a worse safety profile with nHT than the interim analysis, whit distinct profiles among different nHT. The lack of survival data regarding second-line therapies remains a major issue.
Use and Misuse of Emergency Room for Children: Features of Walk-In Consultations and Parental Motivations in a Hospital in Southern Italy
Authors: Calicchio Maria , Valitutti Francesco , Della Vecchia Antonio , De Anseris Anna Giulia Elena , Nazzaro Lucia , Bertrando Sara , Bruzzese Dario , Vajro Pietro 
Published: June 2021

Objective: Inappropriate use of the emergency department (ED) represents a major worldwide issue both in pediatric and adult age. Herein, we aim to describe features of pediatric visits to the ED of Salerno University Hospital and to evaluate parental reasons behind the decision to walk in.Materials and Methods: We performed a retrospective observational study evaluating ED encounters for children from January 2014 to December 2019. The appropriateness of visits was measured with a national tool assessing every ED encounter, namely, “the Mattoni method,” which consists of the combination of the triage code assigned, the diagnostic resources adopted, and the consultation outcomes. Moreover, 64 questionnaires were collected from a sample of parents in the waiting rooms in January 2020.Results: A total number of 42,507 visits were recorded during the study period (19,126 females; mean age ± SD: 4.3 ± 3.8 years), the majority of whom were inappropriate (75.8% over the considered period; 73.6% in 2014; 74.6% in 2015; 76.3% in 2016; 76.7% in 2017; 77.9% in 2018; 75.5% in 2019). Most of the inappropriate consultations arrived at the ED by their own vehicle (94.4%), following an independent decision of the parents (97.2%), especially in the evening and at night on Saturdays/Sundays/holidays (69.7%). A multivariate analysis revealed the following: patients of younger age (OR: 1.11, 95% C.I. 1.06–1.16; p &lt; 0.0019), night visits (OR 1.39; 95% C.I.: 1.32–1.47; p &lt; 0.001), patients living in the municipality of Salerno (OR 1.28; 95% C.I.: 1.22–1.34; p &lt; 0.001), weekend day visits (OR 1.48; 95% C.I.: 1.41–1.56; p &lt; 0.001), and independent parental decision without previous contact with primary care pediatrician (OR 3.01; 95% C.I.: 2.64–3.44; p &lt; 0.001) were all significant independent predictors of inappropriate consultation. The most frequent trigger of ED encounters was fever (51.4%). Hospital admission made up 17.6% of all consultations. The questionnaire showed that most parents were aware of the lack of urgency (20.3%) or minor urgency (53.1%) of the visit. The reasons for walking in were the impossibility to receive a home consultation (70%), the difficulty of contacting their family pediatrician during weekends and holidays (54.4%), as well as the search for a quick, effective, diagnosis and therapy (48.4%).Conclusions: The study suggests a highly inappropriate use of ED for children in our region. This issue deserves considerable attention by health care system leaders in order to optimally integrate hospitals and primary care.
Based on a Decision Tree Model for Exploring the Risk Factors of Smartphone Addiction Among Children and Adolescents in China During the COVID-19 Pandemic
Authors: Duan Li , He Juan , Li Min , Dai Jiali , Zhou Yurong , Lai Feiya , Zhu Gang 
Published: June 2021

Background: Smartphone addiction has emerged as a major concern among children and adolescents over the past few decades and may be heightened by the outbreak of COVID-19, posing a threat to their physical and mental health. Then we aimed to develop a decision tree model as a screening tool for unrecognized smartphone addiction by conducting large sample investigation in mainland China.Methods: The data from cross-sectional investigation of smartphone addiction among children and adolescents in mainland China (n = 3,615) was used to build models of smartphone addiction by employing logistic regression, visualized nomogram, and decision tree analysis.Results: Smartphone addiction was found in 849 (23.5%) of the 3,615 respondents. According to the results of logistic regression, nomogram, and decision tree analyses, Internet addiction, hours spend on smartphone during the epidemic, levels of clinical anxiety symptoms, fear of physical injury, and sex were used in predictive model of smartphone addiction among children and adolescents. The C-index of the final adjusted model of logistic regression was 0.804. The classification accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and AUC area of decision tree for detecting smartphone addiction were 87.3, 71.4, 92.1, 73.5, 91.4, and 0.884, respectively.Conclusions: It was found that the incidence of smartphone addiction among children and adolescents is significant during the epidemic. The decision tree model can be used to screen smartphone addiction among them. Findings of the five risk factors will help researchers and parents assess the risk of smartphone addiction quickly and easily.
Keadilan Dalam Perspektif Hadis
Authors: Siddeh Khoirul Anam 
Published: June 2021

Tulisan ini akan membahas hadis tentang keadilan kaitannya dengan keadilan seorang pemimpin dalam memimpin. Tujuan dari penulisan ini adalah untuk menginventarisir hadis-hadis tentang keadilan dalam kepemimpinan, mengetahui takhrij hadis sehingga mengetahui kulaitas hadis, serta mengetahui makna kandungan hadis kaitannya dengan keadilan pemimpin dan relevansi keadilannya dalam lembaga pendidikan Islam. Metode penelitian in imenggunakan metode penelitian kepustakaan dengan pendekatan maudu’i. Penulis mencari data dengan menginventarisir hadis-hadis dalam Sembilan kitab hadis sesuai dengan tema hadis, kemudian Melakukan takhrij hadis dan membahas hadis dan mengaitknnya dengan keadilan pemimpin dalam lembaga pendidikan. Hasilnya terdapat 45 hadis yang membahas tentang keadilan, dan satu hadis yang paling relevan dengan tema adalah hadis yang terdapat dalam sunan Ad-Darimi nomor 2403. Takhrij hadisnya disimpulkan bahwa hadits tersebut merupakan Hadits shahih. Konsep pemimpin dalam artian yang luas adalah orang yang mempunyai tanggungjawab dalam hal apapun, dan setiap orang yang mempunya tanggungan adalah seorang pemimpin. Kepemimpinan yang adil bertanggungjawab dihadapan manusia dan dihadapan Allah SWT. Demikian juga halnya dengan kepemimpinan di lembaga pendidikan islam. Pemimpin yang adil harus mempunyai kecakapan Ilmu, bertaqwa, berintegritas, jujur, peduli, dan tidak membeda-bedakan orang yang dipimpinnya.
Analisis Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus Terhadap Pengalokasian Belanja Modal (Studi Empiris pada Pada Pemerintahan Kabupaten/Kota di Provinsi Banten Tahun 2013 -2018)
Authors: Raharjo Wilujeng Teguh , Harnovinsah Harnovinsah 
Published: June 2021

This study examines the effect of income original Region, general allocation fund, special allocation fund on allocating capital expenditure on the districts and cities government in Banten Province. This study's populations are four districts and four cities in Banten Province that already have the reports realization region Budget and Expenditure (APBD) in the period 2013-2018, obtained from Directorate-General of Regional Fiscal Balance's official website. This study's analysis test is multiple regression. This study showed that income original region and general allocation fund positively and significantly affect capital expenditure allocation. In contrast, special allocation funds offer a negative and not significant impact on capital expenditure allocation.
PENGGUNAAN MEDIA PEMBELAJARAN BERBASIS KONVENSIONAL DAN TEKNOLOGI INFORMASI OLEH GURU DALAM PROSES BELAJAR MENGAJAR DI SEKOLAH
Authors: Mahfuz Al 
Published: June 2021

Along with the times in the teaching and learning process in which there is a process of interaction between teachers and students, it is also not free from the influence of the times. In the past, teachers in teaching were sufficient to appear in front of the teaching class using simple methods and media, but it is time now that the description of teaching styles and styles has evolved to be more concise in adapting to the conditions of the development of science and technology that continues to develop. Therefore, teachers must have the knowledge and ability to use both conventional and information technology-based learning media in a collaborative manner so that it makes it easier for students to understand learning material through creative and varied presentations so that it will contribute to student achievement.
Keywords: instructional media, conventional, information technology.