bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral herpes keratiti olan hastaların bilateral oküler yüzey ve gözyaşı osmolaritesinin değerlendirilmesi
Authors: BAYHAN Hasan , ASLAN Seray , KÜÇÜK Bekir 
Published: February 2021

Amaç: Bu çalışmada tek taraflı herpetik keratit tanısı ile takip edilen hastaların kuru göz bulgularını ve gözyaşı osmolaritelerini değerlendirmek ve bu bulguların hastalık olmayan diğer gözde var olup olmadığını incelemek amaçlanmıştır.
Gereç ve Yöntemler: Bu prospektif çalışmada kliniğimiz kornea biriminde tek taraflı herpetik keratit tanısı ile takip edilen 40 hastanın keratit olan gözü (Grup 1) ve keratit olmayan diğer gözü (Grup 2) ile 40 kontrol olgusunun bir gözü (Grup 3) değerlendirildi. Olguların detaylı göz muayeneleri ve gözyaşı kırılma zamanı (GYKZ), Schirmer testleri ve osmolarite cihazı ile ölçülen gözyaşı osmolariteleri kaydedildi. Tüm bireylerin alt ve üst kapak meibografi çekimleri yapıldı ve meibomian bez kayıp oranları manuel olarak ölçüldü.
Bulgular: Çalışma grubundaki hastaların (22 erkek, 18 kadın) ortalama yaşı 53,5 ± 9,6 yıl iken, kontrol grubunun (21 erkek, 19 kadın) ortalama yaşı 52,4 ± 9,2 yıl idi (p>0,05). Osmolarite skoru Grup 1 ve 2’de sırasıyla 307,5±6,9 ve 303,4±7,8 mOsm/L iken Grup 3’te 295,5±6,3 mOsm/L olarak bulundu (p
The role of dialogic interaction in EFL writing assessment: A sociocultural perspective
Authors: Moradian Mahmood Reza , Miri Mowla , Alamdar Parvin 
Published: February 2021

This study investigated EFL writing processes through collaborative assessment from a Vygotskian sociocultural perspective. This study focused on assessing essay writing of one intact group of Iranian EFL learners at the intermediate level of language proficiency (N = 15) based on the placement test administered at the institute. Both learners and their teacher assessed essays based on an analytic scale during seven sessions. Moreover, being engaged in collaborative dialogue, the learners were given the opportunity to discuss existing differences between their self-assessed scores and those assigned by the teacher in order to reach an agreed score. Moreover, all their dialogic interactions were audio-recorded for later transcription and micro-analysis. Findings of the microgenetic analysis revealed that benefiting from the mediatory role of the collaborative dialogue and the checklist, the group under investigation gained insight into their capacities, weaknesses, and their metacognitive awareness was raised as the result of conducting CA. The findings suggested that learners took advantage of the collaborative dialogue in which they were engaged while assessing their writing tasks. In particular, the dialogic interaction afforded the learners the chance to present, discuss, and test their ideas and consequently enhance their awareness of the writing tasks. The collaborative assessment could help the learners gain a better insight into their strengths and weakness; further, it led to their metacognitive awareness about components of a good piece of writing.
A preference analysis and justification of Arabic written corrective feedback among instructors and undergraduates
Authors: Abd Hamid Mohd Azrul Azlen , Sahrir Muhammad Sabri , Razali Khairil Azwar 
Published: February 2021

There has been extensive discussion on the need to use corrective feedback in writing within foreign language learning. Essentially, corrective feedback is one of the important tools in improving students’ skills in learning a language. This study aims to find out the preference and justification of written corrective feedback (WCF) through the use of Google Docs among instructors and students in a higher learning institute. The effects of the direct and indirect feedback with metalinguistic comments were also studied to determine their suitability in teaching and learning the Arabic language. Quantitative and qualitative data were collected to (1) identify the preferred type of feedback among instructors and students, (2) identify justification of the preferred feedback type, and (3) examine post-test score differences between types of written correction feedback. Two questionnaires were adapted and distributed to 93 first-year students and four instructors of Arabic language for Academic Writing. Two instructors and five students were interviewed to find out their justification of the preferred types of WCF. A total of 50 respondents were divided into two groups according to the type of WCF provided, and post-test scores between the types of feedback were compared to determine if there was any significant difference between the types of feedback. The findings show that instructors prefer indirect WCF with metalinguistic comments while students prefer direct corrective feedback with metalinguistic comments. Post-test scores indicate that higher scores were achieved by students who received indirect feedback with metalinguistic comments. This indicates that students are able to process indirect feedback that is supplemented with metalinguistic comments. Moreover, an online learning environment provides more opportunities for instructors to highlight the students’ errors more clearly.
Learner autonomy assessment of English language teaching students in an international program in Thailand
Authors: Swatevacharkul Rosukhon , Boonma Nida 
Published: February 2021

The objective of this study was to assess learner autonomy of English Language Teaching students in terms of technical, psychological, political-philosophical, and sociocultural dimensions. The 19 participants were in their first semester of MA ELT, which is an international program in an international university in Thailand. Among them, there were 15 Chinese, three Burmese, and one Thai. This study employed the explanatory mixed-methods design. First, Measuring Instrument for Language Learner Autonomy (MILLA) questionnaire (Murase, 2015) was used to collect quantitative data (QUAN). Then, a semi-structured interview with five participants was carried out to gather follow-up qualitative data (QUAL). The findings revealed that, on average, the students demonstrated a high level of autonomy in all four dimensions. The thematic content analysis generated four themes concerning each autonomy dimension: 1) the use of metacognitive strategies through professional goal setting 2) the intrinsic and extrinsic motivation in support of autonomous learning, 3) the teacher as authority partner in a negotiable learning process, and 4) the preference for self-dependence and collaborative learning. The results of the study can be pedagogically contributive to programs similar to the study’s context with regards to learner autonomy awareness and learner autonomy development.
RETOS ACTUALES Y FUTUROS EN IMPLANTES DE RODILLA Y CADERA
Authors: Gomez Arturo , Mondragón Guillermo , Alvarado Juan Manuel , Camacho Nayeli 
Published: February 2021

En este trabajo se realizó un análisis de la artroplastia de rodilla y de cadera con el fin de identificar los avances más recientes en estos tópicos, así como los retos y perspectivas futuras que se presentan tanto en el ámbito quirúrgico como en el desarrollo de los reemplazos articulares y sus materiales. México cuenta con una gran experiencia clínica en la colocación de prótesis para reemplazo articular de rodilla, cadera, hombro, mano, y tobillo. Asimismo, la experiencia clínica en la colocación de implantes maxilo- y craneo-faciales es extensa. Sin embargo, el resultado del Simposio Nacional - Prótesis ortopédicas: Estatus actual en México (https://protesismexico.com/) mostró que hay una necesidad imperante de diseñar y fabricar implantes que se adapten a la población mexicana, buscando la personalización. Por su parte, en México, la investigación de los materiales para implantes ortopédicos se encuentran en un estado incipiente, pero con perspectivas muy prometedoras en diseño y manufactura aditiva de componentes personalizados, así como sistemas auto-lubricantes que prometen mejores resultados en comparación con sistemas actualmente ofertados en el mercado. El desarrollo de materiales como polímeros de alto peso molecular modificados con nanotubos de carbón o grafeno, así como superficies funcionalizadas con recubrimientos a base de carbón y compuestos tipo diamante, que presentan características auto-lubricantes, podrían incrementar la durabilidad de los implantes, mejorando la calidad de vida para los pacientes.
Valuasi Ekonomi Destinasi Wisata Pulau Harapan, Taman Nasional Kepulauan Seribu, DKI Jakarta
Authors: Ilham Yusuf 
Published: February 2021

Sektor pariwisata adalah salah satu sektor yang sangat potensial untuk meningkatkan devisa negara. Indonesia memiliki banyak destinasi pariwisata alam. Salah satu destinasi pariwisata alam di Indonesia adalah Taman Nasional Kepulauan Seribu. Pada tahun 2018, pemerintah menetapkan Kepulauan Seribu sebagai Kawasan Strategis Pariwisata Nasional (KSPN). Pemerintah menetapkan target penerimaan negara bukan pajak (PNBP) dari Kepulauan Seribu sebesar Rp.150.000.000. Target tersebut harus dicapai dengan proses yang memberikan dampak sekecil mungkin terhadap lingkungan. Salah satu alternatifnya adalah dengan membuat wisata eksklusif. Penelitian ini mengkaji destinasi wisata Pulau Harapan untuk menentukan nilai ekonomi dari destinasi wisata Pulau Harapan dan menyesuaikannya dengan target PNBP dan daya dukung. Metode yang dipakai pada penelitian ini adalah mencari nilai ekonomi menggunakan metode Contingent Valuation Method (CVM) dan mencari Break Even Point (BEP) dan daya dukung optimum di destinasi wisata P.Harapan. Hasil dari penelitian ini, destinasi wisata P.Harapan dapat dijual dengan harga Rp.727.500 dengan jumlah wisatawan yang terbatas yaitu sebanyak 4337 wisatawan.
Tranexamic Acid Reduces the Rate of Periprosthetic Joint Infection After Aseptic Revision Arthroplasty
Authors: Klement Mitchell R. , Padua Fortunato G. , Li William T. , Detweiler Max , Parvizi Javad 
Published: February 2021

Background:
Revision total joint arthroplasty (TJA) has a higher rate of periprosthetic joint infection (PJI) compared with primary TJA, possibly as the result of increased allogeneic blood transfusion. Tranexamic acid (TXA) is gaining popularity in revision TJA to minimize blood loss and the need for transfusion; however, its effect on PJI reduction has yet to be investigated. The hypothesis of this study was that the administration of TXA during revision arthroplasty is protective against subsequent PJI.

Methods:
A prospectively maintained institutional database was used to identify patients who underwent revision TJA for aseptic failure from 2009 to 2018 and had a minimum follow-up of 90 days. Patients who developed PJI following revision arthroplasty were identified. All patients with PJI met Musculoskeletal Infection Society (MSIS) criteria. A multivariate analysis was performed to identify variables independently associated with PJI after aseptic revision TJA.

Results:
Overall, 1,731 patients who underwent aseptic revision were identified; of these patients, 83 (4.8%) developed PJI. Patients who received TXA had significantly lower rates (p = 0.029) of PJI postoperatively at 3.30% compared with those who did not receive TXA at 5.73%. After controlling for relevant confounding variables, TXA remained a significant independent factor that protected against PJI (odds ratio [OR], 0.47 [95% confidence interval (CI), 0.23 to 0.90]; p = 0.030). Female sex was also identified as a significant independent factor that protected against PJI (OR, 0.52 [95% CI, 0.30 to 0.88]; p = 0.016). However, preoperative anemia was independently associated with an increased risk of subsequent PJI (OR, 2.37 [95% CI, 1.34 to 4.16]; p = 0.003).

Conclusions:
Based on this study conducted at a single institution, the use of TXA during aseptic revision arthroplasty was independently associated with a reduced risk of subsequent acute PJI after adjusting for multiple patient characteristics and surgical factors.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Focused Shockwave Treatment for Greater Trochanteric Pain Syndrome
Authors: Ramon Silvia , Russo Sergio , Santoboni Flavia , Lucenteforte Giacomo , Di Luise Carla , de Unzurrunzaga Rocio , Vetrano Mario , Albano Mariantonia , Baldini Rosella , Cugat Ramon , Stella Giulia , Balato Giovanni , Seijas Roberto , Nusca Sveva-Maria , Servodidio Valeria , Vulpiani Maria-Chiara 
Published: February 2021

Background:
Greater trochanteric pain syndrome (GTPS) is a condition of lateral hip pain. Its physiopathology remains unknown, and there is no consensus on optimal management. The aim of this study was to assess the effectiveness of electromagnetic-focused extracorporeal shockwave treatment (F-ESWT) in patients with GTPS.

Methods:
This multicenter clinical trial included 103 patients with chronic GTPS randomly assigned to the treatment group, consisting of electromagnetic F-ESWT and a specific exercise protocol, or the control group, receiving sham F-ESWT and the same exercise protocol. Both groups were treated with 3 weekly sessions; the F-ESWT group received an energy flux density of 0.20 mJ/mm2, whereas the control group received 0.01 mJ/mm2. Patients were assessed at baseline and 1, 2, 3, and 6 months after treatment. A visual analogue scale (VAS) score for pain at 2 months was the primary outcome. The Harris hip score (HHS), Lower Extremity Functional Scale (LEFS), EuroQoL-5 Dimensions Questionnaire (EQ-5D), and Roles and Maudsley score were used as secondary outcomes. Complications were recorded.

Results:
The mean VAS score decreased from 6.3 at baseline in both groups to 2.0 in the F-ESWT group versus 4.7 in the control group at 2 months; the 2-month score differed significantly between groups (p < 0.001). All secondary outcomes at all follow-up intervals were significantly better in the F-ESWT group, except for the LEFS score at 1 month after treatment (p = 0.25). No complications were observed.

Conclusions:
F-ESWT in association with a specific exercise program is safe and effective for GTPS, with a success rate of 86.8% at 2 months after treatment, which was maintained until the end of follow-up.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Clinical Prognostic Model of Autophagy-Related LncRNA Genes in The Esophageal Adenocarcinoma (EAC) to Predicting Overall Survival (OS) of The Patients：The Evidence From Bioinformatic Analysis
Authors: Wu Liusheng , Li Xiaoqiang , Liu Jixian , Wu Da , Wu Dingwang , Xu Pengcheng 
Published: February 2021

Abstract
Objective: Autophagy-related LncRNA genes play a vital role in the development of esophageal adenocarcinoma.Our study try to construct a prognostic model of autophagy-related LncRNA esophageal adenocarcinoma, and use this model to calculate patients with esophageal adenocarcinoma. The survival risk value of esophageal adenocarcinoma can be used to evaluate its survival prognosis. At the same time, to explore the sites of potential targeted therapy genes to provide valuable guidance for the clinical diagnosis and treatment of esophageal adenocarcinoma.Methods: Our study have downloaded 261 samples of LncRNA-related transcription and clinical data of 87 patients with esophageal adenocarcinoma from the TCGA database, and 307 autophagy-related gene data from www.autuphagy.com. We applied R software (Version 4.0.2) for data analysis, merged the transcriptome LncRNA genes, autophagy-related genes and clinical data, and screened autophagy LncRNA genes related to the prognosis of esophageal adenocarcinoma. We also performed KEGG and GO enrichment analysis and GSEA enrichment analysis in these LncRNA genes to analysis the risk characteristics and bioinformatics functions of signal transduction pathways. Univariate and multivariate Cox regression analysis were used to determine the correlation between autophagy-related LncRNA and independent risk factors. The establishment of ROC curve facilitates the evaluation of the feasibility of predicting prognostic models, and further studies the correlation between autophagy-related LncRNA and the clinical characteristics of patients with esophageal adenocarcinoma. Finally, we also used survival analysis, risk analysis and independent prognostic analysis to verify the prognosis model of esophageal adenocarcinoma.Results: We screened and identified 22 autophagic LncRNA genes that are highly correlated with the overall survival (OS) of patients with esophageal adenocarcinoma. The area under the ROC curve（AUC=0.941）and the calibration curve have a good lineup, which has statistical analysis value. In addition, univariate and multivariate Cox regression analysis showed that the autophagy LncRNA feature of this esophageal adenocarcinoma is an independent predictor of esophageal adenocarcinoma.Conclusion: These LncRNA screened and identified may participate in the regulation of cellular autophagy pathways, and at the same time affect the tumor development and prognosis of patients with esophageal adenocarcinoma. These results indicate that risk signature and nomogram are important indicators related to the prognosis of patients with esophageal adenocarcinoma.
Telemedicine in The Context of Covid-19- A Qualitative Study of Cancer Patients and Clinicians
Authors: Kong Dylan Chan Tai , Chauhan Ashfaq , Leung Anaïs Tiffany Ah , Chin Melvin 
Published: February 2021

Abstract
Background:Prior to the Covid-19 pandemic, telemedicine was only used to deliver health care to patients living in remote areas of Australia. However, the spread of the Covid-19 virus pushed the widespread uptake of telemedicine across Australia, including in metropolitan regions. This qualitative study will explore the medical oncology (MO) patient and clinician experience of telemedicine in a metropolitan setting as a result of Covid-19.Method:Participants were selected and invited to participate by theoretical sampling from MO clinicians and patients attending MO clinics at Prince of Wales Hospital. Data was collected by in-depth semi-structured interviews. Thematic analysis was performed to analyse the interview data. Transcripts were coded using the grounded theory approach to identify overarching themes.Results:Twelve participants were recruited to the study. Most participants viewed the adoption of telemedicine positively because it was considered as convenient, efficient and could be used in order to reduce the spread of Covid-19. Nonetheless, participants complained about the poor implementation of telemedicine, technical difficulties and lack of proper training. Finally, providers expressed mixed views over the lack of personal interaction and the lack of physical examination from telemedicine. However, both clinicians and patients viewed telemedicine as acceptable to be used in the context of routine follow-ups.Conclusion:Although some operational improvements are necessary, the role of telemedicine in the follow up of MO patients seems likely to continue beyond Covid-19.
Morphological Features of the Secretory Phase Endometrium in Women With Unexplained Infertility&nbsp;
Authors: Karaoğlan Özdem , KUYUCU Yurdun , Ürünsak İbrahim , Gümürdülü Derya , Tap Özgül 
Published: February 2021

Abstract
Background: In this study, we evaluated the structural features of the endometrial tissues, the immunohistochemical expression of MUC-1, which plays an important role in implantation, and the biochemical markers during the implantation window. Methods: Randomly chosen 18 fertil and 18 infertil women, that have 27-32 days long menstrual cycle, normal hormonal values, normal USG findings of ovary and endometrium were included. Five, six, and seven days after ovulation, endometrial biopsies were taken and prepared in accordance with light and electron microscopy tissue preparation methods. Immunohistochemical methods were used to determine MUC-1 expression in the tissues. Serum hormone levels were determined. Results: The MUC-1 immunoreactivity, as well as the serum levels of FSH, LH, TSH, estrogen, progesterone, and total testosterone did not differ significantly between the two groups; however, prolactin levels were higher in the infertile group. In the infertile samples intraepithelial lymphocytes were frequently observed, the microvilli of the surface columnar epithelium were widespread, cells with pinopodes as well as vesiculated cells were minimal, pinopode development was insufficient, the development of the endometrial glands was deficient. Conclusions: Considering all these findings, it was concluded that these structural differences observed in the surface and glandular epithelium of the endometrium in infertile patients may be due to the insufficiency of these cells in responding to steroid hormones; therefore, these changes may affect the implantation of the blastocyst in the endometrium.
Function of miR-24 and miR-27 in Pediatric Patients With Idiopathic Nephrotic Syndrome
Authors: Ni Fen-fen , Liu Guang-lei , Jia shi-lei , Chen Ran-ran , Liu Li-bing , Li Cheng-rong , Yang Jun , Gao Xiao-jie 
Published: February 2021

Abstract
Background: The specific etiology and mechanism of idiopathic nephrotic syndrome (INS) in children remain unclear, so we investigated the pathogenesis of INS by measuring the effects two specific miRNAs on Th2 cells in children with this disease. Methods: Flow cytometry was used to measure the levels of Th2 cells and a cytometric bead array was used to measure the levels of IgE, interleukin (IL) -4, and IL-13. RT-PCR was used to measure the levels of miR-24 and miR-27 in CD4+TCD25− cells. PBMCs were isolated using Ficoll density gradient centrifugation, and transfected with different mimic or inhibitor miRNAs. RT-PCR was used to measure the expression of different RNAs, and flow cytometry was used to determine the percentages of Th2 cells. Results: Children with active INS had higher percentages of Th2 cells than healthy controls (P<0.05), but there was no significant difference for children in remission. The plasma levels of IgE, IL-4, and IL-13 were significantly increased in children with active INS (P<0.05). miR-24 and miR-27 were at lower levels in children with active non-atopic INS (P<0.05). Transfection experiments indicated that upregulation of each miRNA decreased the percentage of Th2 cells and the level of IL-4 (P<0.05), and down-regulation of each miRNA had the opposite effects (P<0.05). Conclusion: Children with active INS, with or without atopy, had higher levels of IgE, possibly related to their higher levels of IL-13 and IL-4 due to drift toward Th2 cells. miR-24 and miR-27 suppress the expression of Th2 cells and have a critical function in Th2 expression in INS.
Unbuttoning the Impact of N501Y Mutant RBD on viral Entry Mechanism: A Computational Insight
Authors: Sharma Tanuj , Baig Mohammad Hassan , Rahim Moniba , Dong Jae June , Cho Jae-Yong 
Published: February 2021

Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic has become a serious global threat. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for this pandemic has imposed a severe burden on the medical settings. The spike (S) protein of SARS-CoV-2 is an important structural protein playing a key role in the viral entry. This protein is responsible for the receptor recognition and cell membrane fusion process. The recent reports of the appearance and spread of new SARS-CoV-2 strain has raised alarms. It was reported that this new variant containing the prominent active site mutation in the RBD (N501Y) was rapidly spreading within the population. The reported N501Y mutation within the spike's essential part, known as the ‘receptor-binding domain’ has raised several questions. Here in this study we have tried to explore the effect of N501Y mutation within the spike protein using several in silico approaches