bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihyperglycemic, antidyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats
Authors: Onoja SO , Effiong UO , Chukwuocha B.K. , Okorie-Kanu C.C. , Ezeja M.I. , Omeh Y.N. , Anaga A.O. 
Published: January 2021

Purpose: To investigate the antihyperglycemic, anti-dyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats.
Methods: Hydromethanol extract of Eremomastax speciosa leaf was tested at dose range of 25 to 100 mg/kg against vehicle (distilled water) and glibenclamide (2 mg/kg, reference standard) in alloxaninduced hyperglycemic rats. Gas chromatography mass spectrometry (GC-MS) was employed in the identification of phytoconstituents. The fasting blood glucose (FBG), serum lipid profile, malondialdehyde, catalase and superoxide dismutase levels as well as the histopathology of the pancreas of the animals were evaluated.
Results: The extract (25 mg/kg) significantly reduced FBG, lipid profile and malondialdehyde levels relative to vehicle treated group but increased the superoxide dismutase and catalase levels and reversed alloxan-induced pancreatic islet cell degeneration. GC-MS analysis showed the presence of 4,5-dimethylthiazole (4.38%), benzenesulfonic acid, methyl ester (15.62%), benzenesulfonyl chloride (40.62%), benzopyran-4-one, 5,7-dihydroxy-2-phenyl- (21.25%), 2(5H)-furanone, 4-methoxy-5-phenyl-(12.50%), and p-chlorobenzenesulfonyl chloride (5.62%)
Conclusion: The hypoglycemic effect of the extract validates the folkloric uses of E. speciosa leaf in the ethnobotanical care of diabetes mellitus.
Keywords: antihyperglycemic, antioxidant, anti-dyslipidemic, Eremomastax speciosa
Effect of berberine on hyperandrogenemia, ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome
Authors: Lu Kena , Lin Hanmei 
Published: January 2021

Purpose: To study the effect of berberine (BBR) on hyperandrogenemia (HA), ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome (PCOS).Methods: Forty-five female Kunming mice were randomly divided into control group (9 mice), and mice injected with dehydroepiandrosterone (n = 36) for establishment of PCOS model. The PCOS mice were randomly divided into model group, low-dose BBR (0.25 g/kg), medium-dose BBR (0.5 g/kg) and highdose (1.0 g/kg) groups, with 9 mice in each group. Changes in ovarian morphology were monitored, and sex hormone levels i.e. testosterone (T) and luteinizing hormone (LH)), and inflammatory factors were determined.Results: The model group levels of T and LH were significantly higher than those of the blank control group (p < 0.05), but T and LH levels were significantly lower in middle- and high-dose BBR groups than in the model mice. There were marked increases in IL-6 and TNF-α levels in model mice, when compared to blank control mice, but reduced in the mice treated at the 3 doses of BBR, relative to model mice (p < 0.05). In contrast, the number of follicles was higher at each stage of development in mice for each BBR dose than in the model mice, with increase in corpus luteum.Conclusion: Berberine lowers the weight of PCOS mice, mitigates hyperandrogenemia and inflammatory state, and enhances recovery of ovulation. However, there is need for further studies on its clinic applicability.
Keywords: Berberine, Polycystic ovary syndrome, Hyperandrogenemia, Ovulation dysfunction, Inflammatory
Extended warfarin treatment versus rivaroxaban treatment for first episode of symptomatic unprovoked pulmonary embolism: A prospective cohort study
Authors: Pan Jie , Hao Zong , Sun Xiaohong , Gao Hong , Gao Bin 
Published: January 2021

Purpose: To compare the benefits and risks of extra 6 months of warfarin therapy with those of rivaroxaban treatment in patients with initial unprovoked pulmonary embolism (PE) episode who completed 3- or 6-month of therapy on heparin/vitamin K antagonist standard regime.Methods: This prospective observational study included 212 patients with follow-up from July 2013 to July 2018. The primary endpoint was symptomatic recurrent venous thromboembolism (VT), composite of non-fatal symptomatic PE or deep vein thrombosis or fatal VT, and major bleeding (non-fatal/fatal) up to 6 months. Secondary endpoints were death not related to PE or major bleeding.Results: During the 6-month therapy period, the primary endpoint was seen in 3 out of 106 patients (2.83 %) in warfarin category, and in rivaroxaban category, for a hazard ratio (HR) of 1.22 [95 % confidence interval (CI) = 0.09 - 11.18; p = 0.813]. With warfarin therapy, 2 patients (1.89 %) had recurrent VT, while 3 patients (2.83 %) had VT with rivaroxaban. Major bleeding was observed in 2 patients (1.89 %) on warfarin, and in one patient (0.94 %) on rivaroxaban. During the entire 18-month period, the primary endpoint was seen in 15 patients (14.15 %) treated with warfarin, and in 18 patients (16.98 %) treated with rivaroxaban (HR 0.84; 95 % CI = 0.47 - 1.84; p = 0.431). Major bleeding was observed in 5 patients (4.72 %) under warfarin (one fatal), relative to 3 patients (2.83 %) under rivaroxaban (R 1.67; 95 % CI = 0.62 - 5.95; p = 0.09).Conclusion: Rivaroxaban showed higher efficacy than warfarin in recurrent VT prevention, with lower risk of major bleeding. However, the extended therapeutic benefit was not maintained post-therapy.
Keywords: Pulmonary embolism, Rivaroxaban, Warfarin, Heparin, Vitamin K, Hazard ratio
Rhodioloside inhibits apoptosis of hippocampal neurons exposed to sevoflurane via cAMP/PKA signaling pathway
Authors: Su Yuqiang , Bai Yan , Zheng Zhonglei , Fan Xiaoying 
Published: January 2021

Purpose: Neural injury affects patients after using inhalational anesthetics such as sevoflurane. Rhodioloside, a compound which is obtained from the Rhodiola rosea plant has been implicated to be the most commonly used psychostimulant that can improve a range of conditions. The study was aimed at finding the molecular mechanism underlying the Rhodioloside treatment of sevoflurane-injured hippocampal neurons.Methods: Main hippocampal neurons, secluded from Sprague Dawley embryonic rats were employed to create an injury model using 3 % sevoflurane. The sevoflurane-injured hippocampal neurons were treated with varying concentrations (10, 20, 40 and 80 μM/ml) of Rhodioloside to create different experimental groups: RHSD10+SEV, RHSD20+SEV, RHSD40+SEV, RHSD80+SEV, while untreated cells were considered as the Control group. Cell viability was identified using the CCK-8 assay. The CFSE assay was used to verify the promotion function of Rhodioloside on cell differentiation of neurons. FCM assay was employed to determine cell proliferation and apoptosis. Expression levels of apoptosisrelated factors, like Caspase-3, Bcl-2 and Bax were examined by RT-qPCR, while Western blot was used to measure phosphorylation of PKA.Results: Rhodioloside stimulated cell viability and prevented cell apoptosis in sevoflurane-injured hippocampal neurons in doses between 10-80 μM. The apoptosis-inhibitory effect of Rhodioloside was observed to be through cAMP/PKA pathway activation. Also, expression levels of Bcl-2, and PKA were enhanced and the level of Caspase-3 and Bax was reduced in a dose-dependent pattern. The PKA inhibitor reversed the above observation in the 40 μM Rhodioloside-treatment.Conclusion: Rhodioloside promoted cell viability and prevented apoptosis of primary hippocampal neurons injured by sevoflurane, through cAMP/PKA pathway activation. Inhibition of PKA network deteriorated the function of Rhodioloside by stimulating cell apoptosis. Our findings present a novel evidence that Rhodioloside could attenuate neurotoxicity of inhalational anesthetics.
Keywords: Cell apoptosis, cAMP/PKA pathway, Hippocampal neurons, Rhodioloside, Sevoflurane
ĐIỀU KIỆN BIÊN VẬN TỐC TRƯỢT BẬC HAI MỚI CHO MÔ PHỎNG DÒNG KHÍ LOÃNG TỐC ĐỘ CAO
Authors: TUẤN PHƯƠNG NAM LÊ 
Published: January 2021

Trong bài báo này, một điều kiện biên trượt vận tốc bậc hai mới được đề xuất dựa trên sự kết hợp giữa mô hình hấp thụ hạt khí đẳng nhiệt Langmuir trên bề mặt rắn và mô hình khí động học Karniadakis et al. Điều kiện biên trƣợt vận tốc bậc hai mới này được tích hợp vào trong phần mềm mã mở OpenFOAM đề dùng với bộ giải rhoCentralFoam mà giải các phương trình Navier-Stokes-Fourier cho mô phỏng dòng khí loãng. Hai trường hợp cơ bản để kiểm chứng điều kiện biên trượt vận tốc mới cho tính toán mô phỏng dòng khí loãng ở tốc độ cao trên tấm phẳng và dòng khí loãng đi ngang qua hình trụ tròn. Các dòng khí loãng argon và ni-tơ ở tốc độ cao (số Mach từ 4 – 10) đƣợc lựa chọn dể thực hiện mô phỏng cho hai trƣờng hợp trên. Kết quả mô phỏng CFD cho tính toán vận tốc trượt trên bề mặt của dòng khí loãng với điều kiện biên vận tốc trƣợt bậc hai mới trên bề mặt thì tiệm cận với kết quả DSMC cho tất cả các trường hợp đƣợc xem xét trong bài báo và tốt hơn kết quả vận tốc trượt tính toán với điều kiện trượt vận tốc bậc hai Karniadakis et al.
APPLICATION OF EEMD-SVD TECHNIQUE BSOA-SVM METHOD TO FAULT DIAGNOSIS FOR ROLLER BEARING
Authors: HÙNG LINH AO 
Published: January 2021

This study proposes a new method to diagnose roller bearing failure, in which we use EEMD (Ensemble Empirical Mode Decomposition) method combined with the singular value decomposition method (SVD) and support vector machine. (SVM). In addition, the parameters of SVM are selected through Backtracking Search Optimization Algorithm to make BSOA-SVM clasifiers. First, the accelerator vibartion signal is decomposed into IMF (Intrinsic Mode Function) by EEMD method. These IMFs are analyzed separately to create input vectors for SVM classifiers. Finally, BSOA-SVM classifiers are used to classify fault roller bearing patterns. Experimental results show that the proposed method can classify the conditions of roller bearings with higher accuracy and lower time when compared with other methods.
As festas de Reinado no interior da cultura popular de Minas Gerais
Authors: Alves Mikael José Guedes 
Published: January 2021

O presente texto apresenta um breve histórico da formação das festas de reinado no Brasil, de modo especial no estado de Minas Gerais, e evidencia seu processo de consolidação como movimento religioso e cultural, e os principais desafios verificados na sua trajetória. Aponta-se também algumas medidas e iniciativas voltadas à sua preservação, dentre elas algumas empreendidas espontaneamente pelos indivíduos envolvidos no reinado ou pela recente legislação voltada à sua documentação e registro nos órgãos de patrimônio. Por fim, essa breve análise busca indicar as diversas posições que o reinado ocupou no contexto social com base nas propostas de diferentes naturezas a ele recomendadas.
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A (i)materialidade da cultura
Authors: Silva Leonardo Luiz Silveira da , Costa Alfredo 
Published: January 2021

A discussão acerca da materialidade da cultura tomou a cena nos debates da geografia cultural a partir do artigo de Don Mitchell, publicado em 1995. Reanimamos esta discussão a partir de debates recentes que passaram até mesmo pela avaliação acerca da impossibilidade de representação espacial da cultura. Apresentamos neste artigo os resultados de um questionário acerca dos elementos componentes da cultura, que demonstrou a extrema diferenciação nas impressões, apontando para sua intangibilidade. Acrescentamos a abordagem assertiva de Augustin Berque como uma forma de mediar a materialidade e a imaterialidade da cultura, e ao final, alertamos para o risco do descuido discursivo, visto que a reflexão teórica aqui proposta se expressa por intermédio de dialéticas subjetivas, ou trajetivas.
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Geopolitical Status of Ukraine: Historiography and Methodological Discourse
Authors: Kondratenko O. 
Published: January 2021

The issue of Ukraine’s geopolitical status through the prism of historiography and methodological discourse of domestic and foreign scholars is revealed. It is established that in the vast majority of scientific works the geopolitical status of Ukraine is defined as extremely low with a further tendency to deteriorate. It is found out that the decline of Ukraine’s geopolitical status in the international arena began immediately after it acquired non-nuclear status under pressure from Russia and the United States. In the end, the “cassette” and “Kolchuga” scandals caused only a deterioration of both the international image and the geopolitical status of Ukraine. According to the works of leading Ukrainian scholars, the crisis of foreign policy and the decline of geopolitical status of the state were also caused by internal factors. These included the demographic crisis, large-scale corruption and falling GDP, which in turn led to an increase in Ukraine’s negative trade balance.
A significant number of scholars link the weakness of Ukraine’s geopolitical status with its complicated geographical location. Thus, we can agree with the most authors that Ukraine is geographically located between the West and the East, as well as at the intersection of strategic interests of three civilizations: Euro-Atlantic, Eurasian and Islamic. It is this factor, along with Ukraine’s internal problems, that determines the peripherality of Ukraine’s geopolitical position as that of a buffer state. In order to finally transform Ukraine into a “gray” security zone and prevent its rapprochement with the EU and NATO, Russia launched a hybrid war in 2014, as a result of which it annexed Crimea and caused an armed conflict in Donbas. Such actions of Russia led to further weakening of the geopolitical status of Ukraine and its final transformation into an object of policy of powerful international players. In the current circumstances and forecasts, we increasingly share the idea of intensifying the Euro-Atlantic vector of Ukraine’s foreign policy and establishing a strategic security dialogue to strengthen relations with Eastern European neighbors in the framework of the possible implementation of the Baltic-Black Sea project.
KETELADANAN FIGUR LEA DALAM KEJADIAN PASAL 29-30:1-24
Authors: Anna Kristiana , Kusradi Sri Wahyuni 
Published: January 2021

Perempuan yang bersyukur saat ini menjadi sebuah situasi yang sulit dilakukan oleh wanita dalam hidupnya. Kaum wanita hedonis karena tidak hanya merugikan secara rohani, namun juga karakter dan kepribadian individu. Oleh sebab itu penerapan perempuan bersyukur menurut Alkitab sangat penting bagi wanita yang hedonis dan tidak bersyukur dengan melalui pemahaman Firman Tuhan yang benar, mengetahui hakikatnya sebagai umat Allah. Alkitab mengajarkan bahwa menikah untuk menjadi satu dan bukan menjadi sama. Orang akan frustasi apabila menjadikan pernikahan sebagai target untuk menjadi sama, yang sesungguhnya adalah saling melengkapi. Sehingga, sebagai pasangan suami istri seharusnya dapat menerima apa adanya satu sama lain, misalnya; sikapnya, sifatnya, tempramennya, karakternya. Dengan kekurangan ataupun kelebihan yang ada, tidak dapat merubah pasangan dengan mencela, menuntut, ataupun menjadikan sama dengan keinginannya. Firman Tuhan merupakan kebenaran yang akan menuntun orang percaya untuk serupa dengan Kristus Yesus. Kaum wanita hedonis yang tidak bersyukur telah terjadi di berbagai kalangan. Ini merupakan situasi yang memprihatikan, penurunan kualitas secara rohani, dan moral tentunya akan berpengaruh terhadap gereja. Berangkat dari problematika tersebut, jelas bahwa wanita hedonis sangat membahayakan. Dengan pendekatan kualitatif dan metode deskriptif-theologis dalam skripsi ini penulis memberikan implementasi bagi kaum wanita hedonis, sehingga hasil studi ini dapat menjadi acuan bagi kaum wanita dalam meningkatkan kualitas rohaninya.
Today, a grateful woman is a situation that is difficult for women to do in her life. Women are hedonistic because they are not only detrimental to spirituality, but also to individual character and personality. Therefore, the application of women who are grateful according to the Bible is very important for women who are hedonistic and ungrateful, through understanding the true Word of God, knowing their essence as God's people. The Bible teaches that marrying is to be one and not the same. People will be frustrated if they make marriage as the target to be the same, which is actually complementary. So, as a married couple, they should be able to accept each other's existence, for example; his attitude, his character, his temper, his character. With existing weaknesses or strengths, one cannot change a partner by criticizing, demanding, or making the same as what he wants. God's Word is the truth that will lead believers to be like Christ Jesus. Hedonist women who are not grateful have occurred in various circles. This is a situation of concern, spiritual and moral deterioration will certainly affect the church. Departing from these problems, it is clear that hedonistic women are very dangerous. With a qualitative approach and descriptive-theological methods in this thesis, the authors provide an implementation for hedonist women, so that the results of this study can be a reference for women in improving their spiritual quality.
Kepemimpnan Wanita Dalam Gereja
Authors: Manalu Lina 
Published: January 2021

Pemimpin dan kepemimpinan tidak dapat dipisahkan satu dengan yang lainnya. Apabila menyinggung tentang kepemimpinan, hal itu berkaitan dengan mendiskusikan suatu proses. Tetapi berbicara tentang pemimpin Kristen berarti berbicara tentang individu atau pribadi yang dipanggil oleh Tuhan untuk melaksanakan tugas kepemimpinan. Dewasa ini kepemimpinan dalam berbagai bidang telah diwarnai oleh terlibatnya wanita dalam memberikan peran sertanya dalam upaya meningkatkan pembangunan bangsa. Termasuk juga dalam kepemimpinan di gereja. Artikel ini akan memaparkan secara singkat tentang gambaran kepemimpinan wanita dalam gereja
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Leaders and leadership can not be separated from one another. If we mention the leadership, it relates to discuss the process. But talking about the Christian’s leader is talking about private individuals or who are called by God to carry out the task of leadership. Today leadership in various fields has been characterized by the involvement of women in delivering participation in efforts to improve the development of the nation. Included the leadership in the church. This article will explain briefly about the image of women in church of leadership
Konstruksi Kristologi Di Bumi Indonesia
Authors: Harefa Febriaman Lalaziduhu , Paath Jeane , Pasaribu Ferdinan 
Published: January 2021

Kristologi adalah pusat dari disiplin ilmi teologi, karena dalam studi Kristologi memuat tentang Pribadi dan Karya Yesus Kristus dalam rangka penyelamatan umat manusia dari dosa agar manusia memperoleh hidup yang kekal. Namun dewasa ini khususnya di Indonesia, finalitas doktrin Kristologi mengalami pergeseran makna oleh karena studi interpretasi radikal dari beberapa teolog. Bertolak dari pergumulan konteks dan didukung oleh filsafat Postmodern, mereka berusaha untuk melakukan Re-Kristologi yang selama ini diajarkan di dalam gereja-gereja dan menghasilkan model-model Kristologi Kontekstual khususnya yang berkenaan dengan konteks bumi Indonesia. Pendekatan Kristologi ini telah kehilangan makna serta identitasnya dan sangatlah berbeda dengan doktrin Kristologi sebagaimana yang dinyatakan oleh teks-teks Alkitab firman Allah. Kristologi yang benar adalah Kristologi yang bertolak dari pernyataan teks-teks Alkitab kemudian Kristologi tersebut menjawab problematika konteks khususnya di bumi Indonesia.
Christology is the center of the scientific discipline of theology, because in the study of Christology it contains the Person and Work of Jesus Christ in the context of saving mankind from sin so that humans can have eternal life. But today especially in Indonesia, the finality of the Christology doctrine has shifted in meaning because of the study of radical interpretations of some theologians. Starting from the struggle of context and supported by Postmodern philosophy, they tried to do Re-Christology that had been taught in the churches and produced contextual Christology models especially with regard to the context of the Indonesian earth. This Christological approach has lost its meaning and identity and is very different from the Christological doctrine as stated by the biblical texts of God's word. The correct Christology is a Christology that departs from the statement of the biblical texts and then the Christology answers the problematic context especially in Indonesian soil.
Seks Menurut Alkitab Sebagai Kontribusi Bagi Pengajaran Gereja Masa Kini
Authors: Halawa Junius 
Published: January 2021

ABSTRAKSeks menurut Alkitab sebagai kontribusi bagi pengajaran gereja masa kini. Tujuan tulisan ini untuk menggali dan menjelaskan konsep seks di dalam Alkitab. Alkitab adalah firman Allah tertulis sebagai landasan iman dan sumber pengajaran yang sehat, misalnya pendidikan seks kepada jemaat. Jauh sebelum manusia diciptakan Allah telah merancang seks bagi kehidupan manusia. Sehingga seks harus dipahami sebagai karunia Allah yang baik, mulia dan nikmat. Namun pada faktanya sebagian orang mengangap seks sebagai sesuatu yang kotor atau hanya pemuas hawa nafsu manusia. Konsekwensiya ialah banyak orang melakukan tindakan seks yang salah diantaranya: perzinahan, onani atau mastrubasi, homoseksual, lesbian dan pedofilia. Berdasarkan hasil penggalian Alkitab, maka seks menggunakan istilah: “satu daging” dan “bersetubuh”. Lebih dalam Alkitab menyatakan bahwa seks merupakan inisiatif Allah sendiri kepada laki-laki dan perempuan, sehingga seks baik adanya. Seks hanya diizinkan Allah kepada seorang laki-laki dan seorang perempuan yang telah masuk dalam pernikahan yang diberkati Tuhan. Pada hakekatnya seks memiliki empat dimensi, yakni: Dimensi rekreasi, dimensi prokreasi, dimensi relasi dan dimensi refleksi. Jika diamati secara baik antara konsep seks yang disaksikan oleh Alkitab dengan perilaku manusia diera ini, maka telah telah banyak terjadi penyimpangan. Oleh karena itu, fenomena ini merupakan bagian dari tanggungjawab gereja dan hamba Tuhan untuk melakukan langkah-langkah pencegahan dan penangan dosa seksual diantaranya: Memberikan pengajaran seks yang Alkitabiah, membuat program yang kreatif dan inofatif dan melaksanakan pelayanan pastoral konseling. Kata kunci: seks atau seksual.

ABSTRACT
Sex according to the Bible as a contribution to the teaching of the church today. The purpose of this paper is to explore and explain the concept of sex in the Bible. The Bible is the written word of God as a foundation of faith and a source of healthy teaching, for example sex education to the congregation. Long before humans were created God had designed sex for human life. So sex must be understood as a gift from God that is good, noble and delicious. But in fact some people regard sex as something dirty or just satisfying human desires. The consequence is that many people commit wrong sexual acts including: