bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between COVID-19 Confinement, Psychological Adjustment, and Sexual Functioning, in a Sample of Portuguese Men and Women
Authors: Carvalho Joana , Campos Priscila , Carrito Mariana , Moura Catarina , Quinta-Gomes Ana , Tavares Inês , Nobre Pedro 
Published: April 2021

ABSTRACTBackgroundPast research has revealed the detrimental effects of social isolation and physical distancing measures in health related outcomes. However, only recently COVID-19 confinement measures provided a context to test whether such detrimental effects exist in the human sexuality domain.AimThis study was aimed at testing the relationship between COVID-19 confinement levels and sexual functioning domains in men and women, while accounting for the mediating role of psychological adjustment during lockdown.MethodsTwo hundred and forty five men and 417 women completed a web survey on the effects of COVID-19 in sexual health. The reference period includes the first confinement in Portugal (March 19–June 1, 2020). Data were handled under Hays’ procedures for simple mediation analysis.OutcomesMeasurement outcomes included self-reported levels of confinement, IIEF and FSFI scores, and psychological adjustment during lockdown.RESULTSPsychological adjustment during lockdown mediated the relationship between confinement levels and most sexual functioning domains in men but not in women. Also, while confinement levels were not directly related with most sexual functioning domains, psychological adjustment during lockdown did predict lower sexual functioning in both genders.Clinical TranslationFindings support that human sexual functioning should be framed within a contextual perspective, emphasizing how psychological adjustment and situational life stressors, such as lockdown situations, shape individuals’ sexuality. Such perspective should be considered in treatment protocols implemented during current pandemic.Strengths & LimitationsData add to the literature on the effects of lockdown in the sexuality domain. However, the study precludes inference of causality and targets only a little proportion of all the dynamics involved in sexuality during the current historical moment.CONCLUSIONPsychological adjustment during COVID-19 seems to have a role on human sexual functioning, over the single effects of confinement.
Healthcare Professionals’ Experience, Training, and Knowledge Regarding Immigration-Related Law Enforcement in Healthcare Facilities: An Online Survey
Authors: La Charite Jaime , Braverman Derek W. , Goplerud Dana , Norton Alexandra , Bertram Amanda , Berger Zackary D. 
Published: April 2021

AbstractU.S. immigration policies and enforcement can make immigrants fearful of accessing healthcare. Although current immigration policies restrict enforcement in “sensitive locations” including healthcare facilities, there are reports of enforcement actions in such settings.
Repair of frontal sinus fractures: clinical and radiological long-term outcomes
Authors: Alon E E , Glikson E , Shoshani Y , Dobriyan A , Yahalom R , Yakirevitch A 
Published: April 2021

AbstractObjectiveThe long-term clinical and radiological outcomes of patients surgically treated for frontal sinus fracture were assessed.MethodsA retrospective, single-centre analysis was conducted of patients treated for frontal sinus fracture in a tertiary trauma centre between 2000 and 2017. Patients who underwent surgical repair for frontal sinus fracture followed by clinical and radiographical evaluation for at least six months were included.ResultsOf 338 patients admitted with frontal sinus fracture, 77 were treated surgically. Thirty patients met the inclusion criteria for long-term follow-up. The average follow-up duration was 37 months (range, 6–132 months). Reconstruction, obliteration and cranialisation of the frontal sinus fracture were performed in 14, 9 and 7 patients, respectively. Two patients with a reconstructed frontal sinus and one with an obliterated frontal sinus developed mucoceles. One patient developed forehead disfigurement following obliteration.ConclusionLong-term complications of frontal sinus repair using the chosen repair techniques are rare, but patients need to be made aware of these potential complications.
Fencing affects African wild dog movement patterns and population dynamics
Authors: O'Neill Helen M. K. , Durant Sarah M. , Strebel Stefanie , Woodroffe Rosie 
Published: April 2021

AbstractWildlife fences are often considered an important tool in conservation. Fences are used in attempts to prevent human–wildlife conflict and reduce poaching, despite known negative impacts on landscape connectivity and animal movement patterns. Such impacts are likely to be particularly important for wide-ranging species, such as the African wild dogLycaon pictus, which requires large areas of continuous habitat to fulfil its resource requirements. Laikipia County in northern Kenya is an important area for wild dogs but new wildlife fences are increasingly being built in this ecosystem. Using a long-term dataset from the area's free-ranging wild dog population, we evaluated the effect of wildlife fence structure on the ability of wild dogs to cross them. The extent to which fences impeded wild dog movement differed between fence designs, although individuals crossed fences of all types. Purpose-built fence gaps increased passage through relatively impermeable fences. Nevertheless, low fence permeability can lead to packs, or parts of packs, becoming trapped on the wrong side of a fence, with consequences for population dynamics. Careful evaluation should be given to the necessity of erecting fences; ecological impact assessments should incorporate evaluation of impacts on animal movement patterns and should be undertaken for all large-scale fencing interventions. Where fencing is unavoidable, projects should use the most permeable fencing structures possible, both in the design of the fence and including as many purpose-built gaps as possible, to minimize impacts on wide-ranging wildlife.
From civil rights to social policy: the political development of family and medical leave policy
Authors: Ramanathan Kumar 
Published: April 2021

AbstractFamily and medical leave policy in the United States is often noted for its lack of wage compensation, but is also distinctive in its gender neutrality and its broad coverage of several types of leave (combining pregnancy leave with medical, parental, and caregiving leave). This article argues that the distinctive design of leave policy in the United States is explained by its origins in contestation over the civil rights policy regime that emerged in the 1960s. In the early 1970s, women's movement advocates creatively and strategically formulated demands for maternity leave provision that fit an interpretation of this new policy regime's antidiscrimination logic. Because of this decision to advance an antidiscrimination claim, advocates became committed to pursuing a leave guarantee on gender-neutral grounds, which in turn enabled the broad-coverage leave design. This case study suggests that scholars of social policy and American political development should pay greater attention to the impact of civil rights on social policy. This article also contributes to the study of policy development by providing an example of how political actors cross boundaries between policy domains during the policy making process and by presenting a reconceptualization of “policy regimes.”
A New Argument Against Critical-Level Utilitarianism
Authors: Williamson Patrick 
Published: April 2021

AbstractOne prominent welfarist axiology, critical-level utilitarianism, says that individual lives must surpass a specified ‘critical level’ in order to make a positive contribution to the comparative status of a given population. In this article I develop a new dilemma for critical-level utilitarians. When comparatively evaluating populations composed of different species, critical-level utilitarians must decide whether the critical level is a universal threshold or whether the critical level is a species-relative threshold. I argue that both thresholds lead to a range of axiological puzzles and objections as yet undiscussed within the literature, and therefore conclude that critical-level utilitarianism should not be taken as a morally plausible welfarist axiology. I show that certain competitive formulations of critical range utilitarianism are subject to the argument too, and that further attempts to relativise critical levels to a particular group or category of welfare bearer (in particular, individual-relative critical levels) are unsustainable.
Isolated absent right pulmonary artery in an infant with 22q11 deletion
Authors: Garg Ankit , Azad Sushil , Radhakrishnan Sitaraman 
Published: April 2021

AbstractDiGeorge syndrome is a rare spectrum of disorder affecting structures derived from third and fourth pharyngeal pouches characterised by aplasia or hypoplasia of thymus and parathyroid glands, and conotruncal anomalies. Presentation includes infants with hypocalcemic seizures, CHD, or recurrent infection. This case report illustrates a unique combination of proximal interruption of right pulmonary artery and aberrant right subclavian artery in a 3-month-old infant who was subsequently diagnosed as DiGeorge syndrome. This constellation of vascular anomalies in an infant with DiGeorge syndrome has not been previously reported in the literature.
An advanced lentil backcross population developed from a cross between Lens culinaris × L. ervoides for future disease resistance and genomic studies
Authors: Gela Tadesse S. , Adobor Stanley , Khazaei Hamid , Vandenberg Albert 
Published: April 2021

AbstractGenetically accessible variation to some of the abiotic and biotic stresses are limited in the cultivated lentil (Lens culinaris Medik.) germplasm. Introgression of novel alleles from its wild relative species will be useful for enhancing the genetic improvement of the crop. L. ervoides, one of the wild relatives of lentil, is a proven source of disease resistance for the crop. Here we introduce a lentil advanced backcross (LABC-01) population developed in cultivar ‘CDC Redberry’ background, based on L. ervoides alleles derived from an interspecific recombinant inbred population, LR-59-81. Two-hundred and seventeen individuals of the LABC-01 population at BC2F3:4 generation were screened for the race 0 of anthracnose (Colletotrichum lentis) and stemphylium blight (Stemphylium botryosum) under controlled conditions. The population showed significant variations for both diseases and the transfer of resistance alleles into the elite cultivar was evident. It also segregated for other traits such as days to flowering, seed coat colour, seed coat pattern and flower colour. Overall, we showed that LABC-01 population can be used in breeding programmes worldwide to improve disease resistance and will be available as a valuable genetic resource for future genetic analysis of desired loci introgressed from L. ervoides.
THE LATTICE OF SUPER-BELNAP LOGICS
Authors: PŘENOSIL ADAM 
Published: April 2021

AbstractWe study the lattice of extensions of four-valued Belnap–Dunn logic, called super-Belnap logics by analogy with superintuitionistic logics. We describe the global structure of this lattice by splitting it into several subintervals, and prove some new completeness theorems for super-Belnap logics. The crucial technical tool for this purpose will be the so-called antiaxiomatic (or explosive) part operator. The antiaxiomatic (or explosive) extensions of Belnap–Dunn logic turn out to be of particular interest owing to their connection to graph theory: the lattice of finitary antiaxiomatic extensions of Belnap–Dunn logic is isomorphic to the lattice of upsets in the homomorphism order on finite graphs (with loops allowed). In particular, there is a continuum of finitary super-Belnap logics. Moreover, a non-finitary super-Belnap logic can be constructed with the help of this isomorphism. As algebraic corollaries we obtain the existence of a continuum of antivarieties of De Morgan algebras and the existence of a prevariety of De Morgan algebras which is not a quasivariety.
Harmonization of RBSP and Arase Energetic Electron Measurements Utilizing ESA Radiation Monitor Data
Authors: Sandberg Ingmar , Jiggens Piers , Evans Hugh , Papadimitriou Constantinos , Aminalragia‐Giamini Sigiava , Katsavrias Christos , Boyd Alexander J. , O’Brien Thomas Paul , Higashio Nana , Mitani Takefumi , Shinohara Iku , Miyoshi Yoshizumi , Baker Daniel Ν. , Daglis Ioannis A. 
Published: April 2021

AbstractAccurate measurements of trapped energetic electron fluxes are of major importance for the studies of the complex nature of radiation belts and the characterization of space radiation environment. The harmonization of measurements between different instruments increases the accuracy of scientific studies and the reliability of data‐driven models that treat the specification of space radiation environment. An intercalibration analysis of the energetic electron flux measurements of the Magnetic Electron Ion Spectrometer (MagEIS) and the Relativistic Electron‐Proton Telescope (REPT) instruments on‐board the Van Allen Probes (VAP) Mission versus the measurements of the Extremely High Energy Electron Experiment (XEP) unit on‐board Arase satellite is presented. The performed analysis demonstrates a remarkable agreement between the majority of MagEIS and XEP measurements and suggests the rescaling of MagEIS HIGH unit and of REPT measurements for the treatment of flux spectra discontinuities. The proposed adjustments were validated successfully using measurements from ESA Environmental Monitoring Unit (EMU) on‐board GSAT0207 and the Standard Radiation Monitor (SREM) on‐board INTEGRAL. The derived results lead to the harmonization of science‐class experiments on‐board VAP (2012–2019) and Arase (2017–) and propose the use of the data sets as reference in a series of space weather and space radiation environment developments.
The Paleogeography of Laurentia in Its Early Years: New Constraints From the Paleoproterozoic East‐Central Minnesota Batholith
Authors: Swanson‐Hysell Nicholas L. , Avery Margaret S. , Zhang Yiming , Hodgin Eben B. , Sherwood Robert J. , Apen Francisco E. , Boerboom Terrence J. , Keller C. Brenhin , Cottle John M. 
Published: April 2021

AbstractThe ca. 1.83 Ga Trans‐Hudson orogeny resulted from collision of an upper plate consisting of the Hearne, Rae, and Slave provinces with a lower plate consisting of the Superior province. While the geologic record of ca. 1.83 Ga peak metamorphism within the orogen suggests that these provinces were a single amalgamated craton from this time onward, a lack of paleomagnetic poles from the Superior province following Trans‐Hudson orogenesis has made this coherency difficult to test. We develop a high‐quality paleomagnetic pole for northeast‐trending diabase dikes of the post‐Penokean orogen East‐Central Minnesota Batholith (pole longitude: 265.8°; pole latitude: 20.4°; A95: 4.5°; K: 45.6 N: 23) whose age we constrain to be 1,779.1 ± 2.3 Ma (95% CI) with new U‐Pb dates. Demagnetization and low‐temperature magnetometry experiments establish dike remanence be held by low‐Ti titanomagnetite. Thermochronology data constrain the intrusions to have cooled below magnetite blocking temperatures upon initial emplacement with a mild subsequent thermal history within the stable craton. The similarity of this new Superior province pole with poles from the Slave and Rae provinces establishes the coherency of Laurentia following Trans‐Hudson orogenesis. This consistency supports interpretations that older discrepant 2.22–1.87 Ga pole positions between the provinces are the result of differential motion through mobile‐lid plate tectonics. The new pole supports the northern Europe and North America connection between the Laurentia and Fennoscandia cratons. The pole can be used to jointly reconstruct these cratons ca. 1,780 Ma strengthening the paleogeographic position of these major constituents of the hypothesized late Paleoproterozoic supercontinent Nuna.
Intercalated architecture of MA2Z4 family layered van der Waals materials with emerging topological, magnetic and superconducting properties
Authors: Wang Lei , Shi Yongpeng , Liu Mingfeng , Zhang Ao , Hong Yi-Lun , Li Ronghan , Gao Qiang , Chen Mingxing , Ren Wencai , Cheng Hui-Ming , Li Yiyi , Chen Xing-Qiu 
Published: April 2021

AbstractThe search for new two-dimensional monolayers with diverse electronic properties has attracted growing interest in recent years. Here, we present an approach to construct MA2Z4 monolayers with a septuple-atomic-layer structure, that is, intercalating a MoS2-type monolayer MZ2 into an InSe-type monolayer A2Z2. We illustrate this unique strategy by means of first-principles calculations, which not only reproduce the structures of MoSi2N4 and MnBi2Te4 that were already experimentally synthesized, but also predict 72 compounds that are thermodynamically and dynamically stable. Such an intercalated architecture significantly reconstructs the band structures of the constituents MZ2 and A2Z2, leading to diverse electronic properties for MA2Z4, which can be classified according to the total number of valence electrons. The systems with 32 and 34 valence electrons are mostly semiconductors. Whereas, those with 33 valence electrons can be nonmagnetic metals or ferromagnetic semiconductors. In particular, we find that, among the predicted compounds, (Ca,Sr)Ga2Te4 are topologically nontrivial by both the standard density functional theory and hybrid functional calculations. While VSi2P4 is a ferromagnetic semiconductor and TaSi2N4 is a type-I Ising superconductor. Moreover, WSi2P4 is a direct gap semiconductor with peculiar spin-valley properties, which are robust against interlayer interactions. Our study thus provides an effective way of designing septuple-atomic-layer MA2Z4 with unusual electronic properties to draw immediate experimental interest.
A high-conductivity n-type polymeric ink for printed electronics
Authors: Yang Chi-Yuan , Stoeckel Marc-Antoine , Ruoko Tero-Petri , Wu Han-Yan , Liu Xianjie , Kolhe Nagesh B. , Wu Ziang , Puttisong Yuttapoom , Musumeci Chiara , Massetti Matteo , Sun Hengda , Xu Kai , Tu Deyu , Chen Weimin M. , Woo Han Young , Fahlman Mats , Jenekhe Samson A. , Berggren Magnus , Fabiano Simone 
Published: April 2021

AbstractConducting polymers, such as the p-doped poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), have enabled the development of an array of opto- and bio-electronics devices. However, to make these technologies truly pervasive, stable and easily processable, n-doped conducting polymers are also needed. Despite major efforts, no n-type equivalents to the benchmark PEDOT:PSS exist to date. Here, we report on the development of poly(benzimidazobenzophenanthroline):poly(ethyleneimine) (BBL:PEI) as an ethanol-based n-type conductive ink. BBL:PEI thin films yield an n-type electrical conductivity reaching 8 S cm−1, along with excellent thermal, ambient, and solvent stability. This printable n-type mixed ion-electron conductor has several technological implications for realizing high-performance organic electronic devices, as demonstrated for organic thermoelectric generators with record high power output and n-type organic electrochemical transistors with a unique depletion mode of operation. BBL:PEI inks hold promise for the development of next-generation bioelectronics and wearable devices, in particular targeting novel functionality, efficiency, and power performance.
Zooplankton grazing of microplastic can accelerate global loss of ocean oxygen
Authors: Kvale K. , Prowe A. E. F. , Chien C.-T. , Landolfi A. , Oschlies A. 
Published: April 2021

AbstractGlobal warming has driven a loss of dissolved oxygen in the ocean in recent decades. We demonstrate the potential for an additional anthropogenic driver of deoxygenation, in which zooplankton consumption of microplastic reduces the grazing on primary producers. In regions where primary production is not limited by macronutrient availability, the reduction of grazing pressure on primary producers causes export production to increase. Consequently, organic particle remineralisation in these regions increases. Employing a comprehensive Earth system model of intermediate complexity, we estimate this additional remineralisation could decrease water column oxygen inventory by as much as 10% in the North Pacific and accelerate global oxygen inventory loss by an extra 0.2–0.5% relative to 1960 values by the year 2020. Although significant uncertainty accompanies these estimates, the potential for physical pollution to have a globally significant biogeochemical signal that exacerbates the consequences of climate warming is a novel feedback not yet considered in climate research.
Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets
Authors: Luczo Jasmina M. , Bousse Tatiana , Johnson Scott K. , Jones Cheryl A. , Pearce Nicholas , Neiswanger Carlie A. , Wang Min-Xuan , Miller Erin A. , Petrovsky Nikolai , Wentworth David E. , Bronshtein Victor , Papania Mark , Tompkins Stephen M. 
Published: April 2021

AbstractInfluenza viruses cause annual seasonal epidemics and sporadic pandemics; vaccination is the most effective countermeasure. Intranasal live attenuated influenza vaccines (LAIVs) are needle-free, mimic the natural route of infection, and elicit robust immunity. However, some LAIVs require reconstitution and cold-chain requirements restrict storage and distribution of all influenza vaccines. We generated a dry-powder, thermostable LAIV (T-LAIV) using Preservation by Vaporization technology and assessed the stability, immunogenicity, and efficacy of T-LAIV alone or combined with delta inulin adjuvant (Advax™) in ferrets. Stability assays demonstrated minimal loss of T-LAIV titer when stored at 25 °C for 1 year. Vaccination of ferrets with T-LAIV alone or with delta inulin adjuvant elicited mucosal antibody and robust serum HI responses in ferrets, and was protective against homologous challenge. These results suggest that the Preservation by Vaporization-generated dry-powder vaccines could be distributed without refrigeration and administered without reconstitution or injection. Given these significant advantages for vaccine distribution and delivery, further research is warranted.
Directed evolution for high functional production and stability of a challenging G protein-coupled receptor
Authors: Waltenspühl Yann , Jeliazkov Jeliazko R. , Kummer Lutz , Plückthun Andreas 
Published: April 2021

AbstractMembrane proteins such as G protein-coupled receptors (GPCRs) carry out many fundamental biological functions, are involved in a large number of physiological responses, and are thus important drug targets. To allow detailed biophysical and structural studies, most of these important receptors have to be engineered to overcome their poor intrinsic stability and low expression levels. However, those GPCRs with especially poor properties cannot be successfully optimised even with the current technologies. Here, we present an engineering strategy, based on the combination of three previously developed directed evolution methods, to improve the properties of particularly challenging GPCRs. Application of this novel combination approach enabled the successful selection for improved and crystallisable variants of the human oxytocin receptor, a GPCR with particularly low intrinsic production levels. To analyse the selection results and, in particular, compare the mutations enriched in different hosts, we developed a Next-Generation Sequencing (NGS) strategy that combines long reads, covering the whole receptor, with exceptionally low error rates. This study thus gave insight into the evolution pressure on the same membrane protein in prokaryotes and eukaryotes. Our long-read NGS strategy provides a general methodology for the highly accurate analysis of libraries of point mutants during directed evolution.