bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrete Element Modeling of Aeolian-like Morphologies on Comet 67P/Churyumov-Gerasimenko
Authors: Sachse M. , Kappel D. , Tirsch D. , Otto K. A. 
Published: September 2021

Context. Even after the Rosetta mission, some of the mechanical parameters of comet 67P/Churyumov-Gerasimenko’s surface material are still not well constrained. They are needed to improve our understanding of cometary activity or for planning sample return procedures.
Aims. We discuss the physical process dominating the formation of aeolian-like surface features in the form of moats and wind taillike bedforms around obstacles and investigate the mechanical and geometrical parameters involved.
Methods. By applying the discrete element method (DEM) in a low-gravity environment, we numerically simulated the dynamics of the surface layer particles and the particle stream involved in the formation of aeolian-like morphological features. The material is composed of polydisperse spherical particles that consist of a mixture of dust and water ice, with interparticle forces given by the Hertz contact model, cohesion, friction, and rolling friction. We determined a working set of parameters that enables simulations to be reasonably realistic and investigated morphological changes when modifying these parameters.
Results. The aeolian-like surface features are reasonably well reproduced using model materials with a tensile strength on the order of 0.1–1 Pa. Stronger materials and obstacles with round shapes impede the formation of a moat and a wind tail. The integrated dust flux required for the formation of moats and wind tails is on the order of 100 kg m−2, which, based on the timescale of morphological changes inferred from Rosetta images, translates to a near-surface particle density on the order of 10−6–10−4 kgm−3.
Conclusions. DEM modeling of the aeolian-like surface features reveals complex formation mechanisms that involve both deposition of ejected material and surface erosion. More numerical work and additional in situ measurements or sample return missions are needed to better investigate mechanical parameters of cometary surface material and to understand the mechanics of cometary activity.
Normierung der deutschen Fassung der Highly Sensitive Person Scale
(HSPS-G) – Selbstbeurteilungsskala an einer deutschsprachigen
Stichprobe
Authors: Herzberg Philipp Yorck , Fricke Kai R. , Konrad Sandra 
Published: September 2021

Zusammenfassung
Problem Die deutsche Fassung der Highly Sensitive Person Scale (HSPS-G)
ist ein Verfahren zur Feststellung der Ausprägung des Merkmals
Feinfühligkeit. Diese Skala wurde bisher in der deutschen Fassung
validiert (Konrad & Herzberg, 2017), eine Normierung für die
deutschsprachige Allgemeinbevölkerung steht allerdings noch aus.
Methode Zur Erstellung von Normwerten der Skala für die
Allgemeinbevölkerung wurden N=7458 Personen (n=6251
Frauen, n=1207 Männer) im Alter von 14–80 Jahren
(MW=37.80, SD=11.75) im deutschsprachigen Raum (Deutschland,
Österreich, Schweiz) online befragt.
Ergebnisse Die Varianzanalyse zeigte höhere Werte für
Frauen, so dass geschlechtsspezifische Normen notwendig sind. Daher werden
geschlechtsspezifische Normwerte für die Subskalen der HSPS-G als auch
für den HSPS-G-Gesamtscore bereitgestellt. Mit diesen
Prozenträngen und T-Werten stehen erstmals Vergleichsdaten für
das im deutschen Sprachraum etablierte Instrument zur Verfügung, die die
Interpretation interindividueller und intraindividueller Unterschiede vor dem
Hintergrund von Bevölkerungsangaben erlauben.
Practicability of a Virtual Consultation to Evaluate the Shoulder Joint
Authors: Gathen Martin , Cucchi Davide , Jansen Tom , Goost Hans , Schildberg Frank Alexander , Burger Christof , Wirtz Dieter Christian , Kabir Koroush , Welle Kristian 
Published: September 2021

Abstract
Objective In the course of the corona pandemic, resource conservation and the protection of further infections have made it necessary to break new ground in the organisation of
orthopaedic and trauma surgery consultations. One solution is consistent digitisation and the offer of video consultation hours. In this study, non-contact examination of patients with
shoulder disorders is described and critically examined.
Methods Thirty patients who presented with pathologies of the shoulder joint in a university outpatient clinic were subjected to a physical examination in a conventional and
contactless manner. The data obtained on mobility, function and provocation test of both examinations were compared to draw conclusions about the virtual feasibility.
Results 46% of the patients suffered from a traumatic shoulder lesion, and 54% showed degenerative lesions. The assessment of mobility showed a high correlation of 70 – 90% between
the two examinations. Common tests to evaluate the supraspinatus, infraspinatus, subscapularis and the long head of the biceps could be adequately performed in a contactless version by more
than three quarters of the patients, but with low-to-moderate performance values.
Conclusion Contact-less examination is particularly disadvantageous when evaluating stability criteria. For the medical history and functional test, there were no significant
differences between the classic consultation and contactless consultation. Although virtual consultation is a widespread and valuable addition in pandemic times, it cannot replace a safe
assessment and indication by personal examination.
COVID-19 Presented with Deep Vein Thrombosis in a Patient with Paroxysmal Nocturnal Haemoglobinuria
Authors: Pravdic Zlatko , Mitrovic Mirjana , Bogdanovic Andrija , Virijevic Marijana , Sabljic Nikica , Pantic Nikola , Vukovic Nada Suvajdzic 
Published: September 2021

AbstractParoxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired clonal haematological disease characterized by complement-mediated haemolysis, bone marrow failure and venous thrombosis. Anticomplement therapy eculizumab improves survival and reduces complications. Severe acute respiratory distress syndrome corona virus 2 (SARS-CoV-2) disease 2019 (COVID-19) is associated with high incidence of both venous and arterial thrombosis in hospitalized patients with pneumonia. Deep venous thrombosis (DVT) as the presenting symptom of COVID-19 is a rare event. We describe a well-controlled PNH patient on eculizumab for more than 5 years who presented with DVT, while on warfarin, as the first sign of COVID-19. To our knowledge, this is the first described case of DVT in a PNH patient with COVID-19.
Die Arthrodese des Fingerendgelenkes: eine Literaturanalyse
Authors: Vonderlind Hans Christoph , Eisenschenk Andreas , Strüwer Johannes , Millrose Michael 
Published: September 2021

ZusammenfassungDiese Arbeit gibt einen Überblick über Techniken und Ergebnisse der Arthrodese des Finger- und Daumenendgelenkes unter Berücksichtigung der Indikation, des Zuganges, der Gelenkflächenpräparation, des Arthrodesenwinkels, der Vor- und Nachteile der einzelnen Techniken und der Nachbehandlung.
Patientenverfügungen von Bewohnenden in Pflegeeinrichtungen – welche Behandlungssituationen und Behandlungsmaßnahmen werden vorausverfügt?
Authors: Klemmt Malte , Neuderth Silke , van Oorschot Birgitt , Henking Tanja 
Published: September 2021

Zusammenfassung
Einleitung Die Möglichkeit, mittels Patientenverfügung Einfluss auf die spätere Behandlung im Falle der Einwilligungsunfähigkeit zu nehmen, gilt heutzutage als wichtiges Element zur Wahrung der Patientenautonomie am Lebensende. Behandlungsmaßnahmen bereits im Vorfeld einer Behandlung abzulehnen oder in diese einzuwilligen, ist für Bewohnende stationärer Pflegeeinrichtungen nicht nur vor dem Hintergrund der COVID-19-Pandemie von besonderer Bedeutung.
Methoden Es wurde eine Vollerhebung aller Vorsorgedokumente von Bewohnenden in 13 stationären Pflegeeinrichtungen unterschiedlicher Größe und Trägerschaft in der Stadt und dem Landkreis Würzburg durchgeführt. Die Analyse der Dokumente erfolgte nach deduktiv-induktivem Vorgehen mittels kategorialer Zusammenfassungen und deskriptiver Häufigkeitsauszählungen.
Ergebnisse In 265 erfassten Patientenverfügungen konnten 2072 Behandlungssituationen und 1673 medizinische Behandlungsmaßnahmen identifiziert werden. Bewohnende stimmen symptomlindernden und pflegerischen Maßnahmen größtenteils zu und lehnen lebensverlängernde bzw. -erhaltende Behandlungsmaßnahmen häufig ab, wobei letztgenannte zumeist auf bestimmte, festgelegte Behandlungssituationen beschränkt werden. Die Bezugnahme auf bestimmte Behandlungssituationen konnte beim Reanimationsversuch, sowohl in Form der Ablehnung wie der Einwilligung, in 88,6 % der Patientenverfügungen festgestellt werden. 62 % der Patientenverfügungen konnten einer Formularvorlage zugeordnet werden.
Diskussion Die Untersuchung liefert Erkenntnisse über den Inhalt von Patientenverfügungen bei Bewohnenden stationärer Pflegeeinrichtungen. Sie gibt damit Hinweise auf medizinische Behandlungswünsche dieser Personengruppe im Falle der Einwilligungsunfähigkeit und zeigt auf, dass Behandlungsmaßnahmen (auch Reanimation) häufig in Bezug zu spezifischen Behandlungssituationen gesetzt werden.
Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever:
Association with Subclinical Inflammation
Authors: Onder Esra Nagehan Akyol , Ertan Pelin 
Published: September 2021

Abstract
Background Familial Mediterranean fever (FMF) is the most seen monogenic
periodic fever syndrome characterised by bouts of fever and serositis. It is
known that subclinical inflammation (SI) can persist in the symptom-free period
and lead to amyloidosis even under colchicine treatment. This study aimed to
evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its
correlation with SI.
Material and Methods A total of 112 patients with FMF and 78 controls were
enrolled in this retrospective study. Demographic, laboratory and genetic data
were obtained from the hospital records.
Results The FAR values of the FMF cases were significantly higher than the
control group (p<0.001). In the FMF group, the patients with SI had
higher FAR values than those without SI (p<0.001). FAR was positively
correlated with SI (r=0.413, p<0.001). The receiver operating
characteristic curve analysis showed that FAR had a higher area under the curve
value than albumin and fibrinogen.
Conclusion Detecting SI in patients with FMF is crucial in preventing
amyloidosis, the most devastating complication of FMF. FAR is a simple,
inexpensive, easily obtained indicator which can be used for reflecting SI in
FMF.
Erectile Dysfunction after Conservative Treatment of Sacral Fractures in Males without Injury to the Urinary System
Authors: Bayrak Alkan , Duramaz Altug 
Published: September 2021

Abstract
Background This study aimed to determine the incidence of erectile dysfunction (ED) reported by patients, and to define the prognostic relationship between ED and conservatively
treated sacral fracture without urethral injury.
Methods Patients aged between 20 – 50 years who were sexually active and had no known sexual dysfunction prior to the trauma were included in the study. Seventy-seven patients (47
married, 30 single) treated conservatively for sacral fracture between April 2012 and February 2017 were retrospectively screened. Patients were compared in terms of age, marital status,
body mass index (BMI), trauma mechanism, additional system injury, functional outcomes, and complications. Functional outcomes were assessed using the International Index of Erectile
Function (IIEF-5) and the Majeed pelvic fracture functional assessment scale (MPS).
Results No statistically significant difference was observed between fracture types with respect to age, BMI, follow-up, marital status, trauma mechanism, and accompanying injury.
The incidence of ED was 27.3% for those that received conservative treatment after sacrum fracture. The mean score of IIEF-5 was 18.6 ± 6.6 and MPS was 77.2 ± 13.2. There was no significant
relationship between the injury type of the patients and the IIEF-5 and MPS scores (p = 0.593 and p = 0.907, respectively). The lowest IIEF-5 score was found in Denis type 2 fractures
(p = 0.020).
Conclusion The frequency of ED was higher in Denis type 2 sacrum fractures. Sexual function should be questioned in the follow-up, especially in those fracture types.
The Low Copy Nuclear Gene Region, Granule Bound Starch Synthase (GBSS1), as a Novel Mini-DNA Barcode for the Identification of Different Sage (Salvia) Species
Authors: Parveen Iffat , Techen Natascha , Handy Sara M. , Li Jing , Wu Charles , Chittiboyina Amar G. , Khan Ikhlas A. 
Published: September 2021

AbstractMorphological similarity within species makes the identification and authentication of Salvia species challenging, especially in dietary supplements that contain processed root or leaf powder of different sage species. In the present study, the species discriminatory power of 2 potential DNA barcode regions from the nuclear genome was evaluated in 7 medicinally important Salvia species from the family Lamiaceae. The nuclear internal transcribed spacer 2 and the exon 9 – 14 region of low copy nuclear gene WAXY coding for granule-bound starch synthase 1 were tested for their species discrimination ability using distance, phylogenetic, and BLAST-based methods. A novel 2-step PCR method with 2 different annealing temperatures was developed to achieve maximum amplification from genomic DNA. The granule-bound starch synthase 1 region showed higher amplification and sequencing success rates, higher interspecific distances, and a perfect barcode gap for the
tested species compared to the nuclear internal transcribed spacer 2. Hence, these novel mini-barcodes generated from low copy nuclear gene regions (granule-bound starch synthase) that were proven to be effective barcodes for identifying 7 Salvia species have potential for identification and authentication of other Salvia species.
An Attempt to Achieve Hydrated Imidazoline Ring Expansion (HIRE) of Diarene-Fused [1,4]Diazepinones Delivers Selective Dopamine D2 Receptor Ligands
Authors: Krasavin Mikhail , Grintsevich Sergey , Sapegin Alexander , Duszyńska Beata , Bojarski Andrzej J. 
Published: September 2021

AbstractAttempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) did not result in ring expansion but, rather, led to 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2 ligands with elements of structure–activity relationships.
Gram-Scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles
Authors: Barbasiewicz Michał , Tryniszewski Michał 
Published: September 2021

AbstractA series of acyl fluorides was synthesized at 100 mmol scale using phase-transfer-catalyzed halogen exchange between acyl chlorides and aqueous bifluoride solution. The convenient procedure consists of vigorous stirring of the biphasic mixture at room temperature, followed by extraction and distillation. Isolated acyl fluorides (usually 7–20 g) display excellent purity and can be transformed into sterically hindered amides and esters when treated with lithium amide bases and alkoxides under mild conditions.
Intestinal Malrotation, Mesocolic Hernia, and Meckel Diverticulum – Differential Diagnosis of Abdominal Pain in Adults: Case Report and Literature Review
Authors: Costa Marcus Vinícius Silva , Alencastro Márcia Cristina de , Linica Samyra Braz de , Ferreira Tiago dos Santos , Bezerra Edson Soares , Bisogni Sérgio 
Published: September 2021

AbstractIntestinal malrotation is a congenital anomaly caused by incomplete rotation or absence of rotation of the primitive intestine along the axis of the upper mesenteric artery during embryonic development. Embryonic development and its anatomical variations were described by Dott in 1923.Intestinal malrotation is a rare condition among adults – prevalent in a mere 0.0001% to 0.19% of the population –, and it may be associated with other anatomical deformities. It can be asymptomatic or manifest with varying intensity, from obstruction to necrosis of intestinal segments. In general, this abnormality is diagnosed in the first year of life; however, symptoms may appear later in life, making diagnosis in adults difficult on account of non-specific symptoms.In the present study, we report a case of intestinal malrotation associated with chronic non-specific symptoms progressing to mesenteric angina.
Study of the Chromosomal Abnormalities and Associated Complex Karyotypes in Hematological Cancer in the Population of West Bengal: A Prospective Observational Study
Authors: De Puspal , Mukhopadhyay Madhumitha J 
Published: September 2021

AbstractIntroduction Chromosomal instability is an important feature of hematological cancer. The pathogenesis is complex and it involves genetic and epigenetic factors. As a genetic factor, chromosomal instability may play a key role in leukemogenesis. Accumulation of genetic alteration is mainly responsible for numerical and structural chromosomal rearrangement or clonal evaluation. But disease progression is often driven by chromosomal translocation, hyper- or hypodiploidy with structural abnormalities, and complex karyotypes.Objective This research aimed to study the different types of chromosomal abnormalities in clinically suspected hematological cancer patients.Materials and Methods Cytogenetic analysis was performed based on phytohemaglutinin stimulated peripheral blood lymphocyte cultures and bone marrow culture, without mitogen, of the respective patients of West Bengal from March 2016 to February 2018. All clinically suspected hematological cancer patients referred for karyotyping to the institutional genetics department have been included without any biasness of sex and age. Karyotypes were described according to the International System for Cytogenetic Nomenclature (ISCN 2005).Results In the present study, 56 clinically suspected hematological cancer cases were observed and 41 cases of chromosomal rearrangement were found which clearly show chromosomal instability as the main driving force for hematological cancer transformation. Presence of variant Philadelphia chromosomes with classical translocation, mosaic complex karyotypes, variable numerical, and structural chromosomal abnormality, along with severe-to-moderate hypo- and hyperdiploidy, and presence of marker chromosomes were the main findings of this study.Conclusion The result shows that the detection of chromosomal instability was important for preliminary diagnosis, treatment, prognosis, and further management. So the present study provided additional information about chromosomal instability in hematological cancer at Kolkata and adjoining regions.
Evidence for the Application of Sepsis Bundles in 2021
Authors: Plata-Menchaca Erika P. , Ruiz-Rodríguez Juan Carlos , Ferrer Ricard 
Published: September 2021

AbstractSepsis represents a severe condition that predisposes patients to a high risk of death if its progression is not ended. As with other time-dependent conditions, the performance of determinant interventions has led to significant survival benefits and quality-of-care improvements in acute emergency care. Thus, the initial interventions in sepsis are a cornerstone for prognosis in most patients. Even though the evidence supporting the hour-1 bundle is perfectible, real-life application of thoughtful and organized sepsis care has improved survival and quality of care in settings promoting compliance to evidence-based treatments. Current evidence for implementing the Surviving Sepsis Campaign bundles for early sepsis management is moving forward to better approaches as more substantial evidence evolves.
How Antibiotics Stewardship Can Be Safely Implemented in Patients with Septic Shock?
Authors: de Montmollin Etienne , Timsit Jean-François 
Published: September 2021

AbstractIn critically ill patients with sepsis and septic shock, the need for prompt and adequate antibiotic therapy is balanced by the risk of excessive antibiotic exposure that leads to emergence of multidrug-resistant pathogens. As such, antibiotic stewardship programs propose a set of operating rules from antibiotic treatment initiation to de-escalation and finally cessation. In this review, we will describe the rationale for early antibiotic treatment in septic patients, how to optimize initial antibiotic treatment, rules for early treatment discontinuation in pathogen-negative sepsis, and optimal duration of antimicrobial therapy.
Survival Outcome of Sepsis in Recipients of Solid Organ Transplant
Authors: Florescu Diana F. , Kalil Andre C. 
Published: September 2021

AbstractSepsis is a complex disease stemming from a dysregulated immune response toward an infectious agent. In transplantation, sepsis remains one of the leading causes of morbidity and mortality. Solid organ transplant recipients have impaired adaptive immunity due to immunosuppression required to prevent rejection. Immunosuppression has unintended consequences, such as increasing the risk of infections and sepsis. Due to its high morbidity and mortality, early detection of sepsis is paramount to start aggressive treatment. Several biomarkers or combination of biomarkers of sepsis have emerged in the last decade, but they are not dependable for early diagnosis or for outcome prognosis.
Elaboration and Validation of Flowchart for the Prevention and Treatment of Intestinal Peristomal Skin Complications
Authors: Cardoso Imaculada Aparecida , Salomé Geraldo Magela , Mendonça Adriana Rodrigues Dos Anjos , Miranda Flávio Dutra , Alves José Ronaldo 
Published: September 2021

Abstract
Objective To build and validate a flowchart for the prevention and treatment of intestinal peristomal skin complications.
Method For the construction of the algorithms, a systematic review was carried out in health sciences databases comprising the last 10 years. The evaluation of the algorithms was carried out by 38 nurses. For the validation of the algorithms, the Delphi technique was used. The statistical analysis used was the content validity index and the Cronbach alpha coefficient. The questionnaire was sent by e-mail and in person after approval by the Ethics and Research Committee.
Results In the first evaluation of the algorithms, there was no agreement among the experts. However, after making the corrections suggested by the evaluators, the algorithms were resent, with a 100% consensus among the evaluators. The questions used to validate the algorithms contributed favourably to the internal consistency and content validation of the instrument, since the respective Cronbach alpha was 0.9062 and the global content validity index (g-CVI) was 0.91 in the first validation and 1.0 in the second validation.
Conclusion After an integrative literature review, the flowcharts were built and validated by a professional with experience in the area, showing 100% agreement among the experts in the second evaluation.
In-office Endonasal Minor Revision Rhinoplasty
Authors: Auger Samuel R. , Shah Anil R. 
Published: September 2021

AbstractThe revision rhinoplasty presents many unique challenges to the facial plastic surgeon. While many cases will require a full revision in the operating room, there are several isolated deformities which may be repaired in the office via an endonasal approach. This provides many benefits to the patient and surgeon including decreased cost, shorter recovery time, avoidance of general anesthesia, and less discomfort. It is critical to identify defects appropriate for endonasal repair, establish clear expectations with the patient, and work within one's skill set and level of experience. The surgeon who can comfortably navigate both open and endonasal techniques can offer their patients a comprehensive set of solutions for revision rhinoplasty. In this article we outline the defects amenable to this type of repair as well as technical considerations for each defect addressed. We hope it serves as a useful framework for the range of deformities the rhinoplasty surgeon may take on for in-office repair.