bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the First Sorption Cycle of White Portland Cement by 1H NMR
Authors: Nagmutdinova Anastasiia , Brizi Leonardo , Fantazzini Paola , Bortolotti Villiam 
Published: October 2021

AbstractThis work is focused on the effects of drying/re-saturation cycles on the structure and components of White Portland Cement (WPC) samples. In particular, WPC of 0.5 water-to-cement ratio was studied by 1H Nuclear Magnetic Resonance (NMR) Relaxometry. A number of NMR sequences and different data processing methods were applied. Short (14 days of re-saturation) and long (6 months for the whole cycle) sorption cycles were investigated, using two drying methods: oven drying and drying under controlled relative humidity. The evolution during drying/re-saturation processes of interlayer space, gel pores, and bigger pores was followed by both the transverse relaxation times and the intensities of the nuclear magnetization. As a result of drying, reversible and irreversible changes in the pore structure, especially concerning the smaller porosity (interlayer and gel pores), were seen. Likewise, 1H signals in the crystalline phases of the cement were investigated by the standard Quadrature Echo method and by a more informative analysis based and a proper acquisition and processing of the longitudinal relaxation data. This analysis allowed the signal separation of 1H nuclei with higher and lower mobility (“solid” components). The NMR signal from this last component was analyzed on the basis of the Pake-Doublet theory in the time domain and two components were clearly detected, and assigned to 1H nuclei of crystalline water in Ettringite and OH groups in Portlandite. Reversible changes of the solid components of the cement samples were observed. This is a new method to deeply investigate the changes of solid components during sorption cycles.
Combining acoustic telemetry with a mechanistic model to investigate characteristics unique to successful Atlantic salmon smolt migrants through a standing body of water
Authors: Lilly Jessie , Honkanen Hannele M. , McCallum Joseph M. , Newton Matthew , Bailey David M. , Adams Colin E. 
Published: October 2021

AbstractThe Atlantic salmon, Salmo salar Linnaeus 1758, is a charismatic, anadromous species that has faced dramatic declines throughout its range. There is currently a lack of information on the effect of free-standing bodies of water on a key life event, sea migration, for the species. This study extends our understanding in this area by combining acoustic telemetry with a correlated random walk model to try to examine potential morphological and behavioural factors that differentiate successful from unsuccessful migrants through Scotland’s largest lake. Consistent with other studies, we found that smolts experienced a high rate of mortality in the lake (~ 43%), with approximately 14% potentially predated upon by birds and 4% by Northern pike. Migration speed in the lake was slow (the mean minimum movement speed between centres of activity was 0.13 m/s), and pathways frequently deviated away from the outlet river. There was no evidence of a morphological or behavioural trait or migratory pathway that distinguished successful from unsuccessful smolts. This suggests that migration movement direction in the main body of Loch Lomond appeared to be random. This was further supported by the output of a correlated random walk model which closely resembled the pathway and migration speed and distance patterns displayed by successful migrants. However, once successful smolts came within ~2 km of the lake exit, a high proportion remained in this region prior to entering the River Leven. We suggest that this “goldilocks zone” is where directional cues become apparent to migrating fish. Future studies should combine random walk models with environmental variables to determine if external factors are driving the apparently random movement patterns exhibited by smolts in lakes.
Noncommutative symplectic manifolds for self-injective Nakayama algebras
Authors: Pogorzały Zygmunt 
Published: October 2021

AbstractIn the paper, we study noncommutative symplectic manifolds $$(A,\llbracket \omega \rrbracket )$$

(
A
,
〚
ω
〛
)

, where A is a self-injective Nakayama algebra. There is given a full description of exact symplectic manifolds for A being the trivial extension of an hereditary Nakayama algebra.
Dynamic response of multi-degree-of-freedom systems with a Coulomb friction contact under harmonic excitation
Authors: Marino Luca , Cicirello Alice 
Published: October 2021

AbstractThis paper investigates the steady-state response of a harmonically excited multi-degree-of-freedom (MDOF) system with a Coulomb contact between: (1) a mass and a fixed wall; (2) two different masses; (3) a mass and an oscillating base. Although discrete MDOF models are commonly used at early design stages to analyse the dynamic performances of engineering structures, the current understanding of the friction damping effects on MDOF behaviour is still limited due to the absence of analytical solutions. In this contribution, closed-form expressions of the continuous time response, the displacement transmissibility and the phase angle of each mass of the system are derived and validated numerically for 2DOF and 5DOF systems. Moreover, the features of the analytical response are investigated, obtaining the following results: (i) the determination of the minimum amounts of friction for which the resonant peaks become finite and (ii) for which stick-slip motion can be observed at high frequencies; (iii) an equation for the evaluation of invariant points for the displacement transmissibilities; (iv) a better understanding of phenomena such as the inversions of the transmissibility curves and the onset of additional resonant peaks due to the permanent sticking of the mass in contact. All these results show that MDOF systems exhibit significantly different dynamic behaviours depending on whether the friction contact and the harmonic excitation are applied to the same or different masses.
Transcriptome analysis shows nicotinamide seed treatment alters expression of genes involved in defense and epigenetic processes in roots of seedlings of Picea abies
Authors: Laurell Cecilia , Berglund Torkel , Ohlsson Anna B. 
Published: October 2021

AbstractNicotinamide treatment of plants and plant cell cultures has been shown to promote defense and decrease levels of DNA methylation. In the present study, we used RNA-seq technology to study overall changes in gene expression induced in roots of 3-month-old spruce (Picea abies) seedlings grown from nicotinamide-treated seeds to examine the molecular mechanisms underlying the defense promotion. Approximately 350 genes were identified as differentially expressed in roots after the seed treatment. Stress response genes, including transcription factors MYB77 and LHY and two chitinase enzymes, were generally upregulated, whereas genes thought to be involved in epigenetic regulation such as DDM1, known to promote DNA methylation, were present at high frequency among the downregulated genes. Across all samples, the expression of downregulated epigenetic-related genes was highly correlated with the nicotinamide treatment, indicating a common regulation. Our results support an earlier hypothesis regarding a potential role of nicotinamide as a defense-signal mediator.
The Biology of Synovial Sarcoma: State-of-the-Art and Future Perspectives
Authors: Fiore Michele , Sambri Andrea , Spinnato Paolo , Zucchini Riccardo , Giannini Claudio , Caldari Emilia , Pirini Maria Giulia , De Paolis Massimiliano 
Published: October 2021

Opinion statementNew molecular insights are being achieved in synovial sarcoma (SS) that can provide new potential diagnostic and prognostic markers as well as therapeutic targets. In particular, the advancement of research on epigenomics and gene regulation is promising. The concrete hypothesis that the pathogenesis of SS might mainly depend on the disruption of the balance of the complex interaction between epigenomic regulatory complexes and the consequences on gene expression opens interesting new perspectives. The standard of care for primary SS is wide surgical resection combined with radiation in selected cases. The role of chemotherapy is still under refinement and can be considered in patients at high risk of metastasis or in those with advanced disease. Cytotoxic chemotherapy (anthracyclines, ifosfamide, trabectedin, and pazopanib) is the treatment of choice, despite several possible side effects. Many possible drug-able targets have been identified. However, the impact of these strategies in improving SS outcome is still limited, thus making current and future research strongly needed to improve the survival of patients with SS.
Odonate fauna assemblages in the “Cansiglio Forest” (Insecta: Odonata)
Authors: Uboni Costanza , Borsato Veronica , Bacaro Giovanni 
Published: October 2021

AbstractOdonata is considered a “flagship” group of insects and its investigation is of primary importance especially for protected areas where freshwater ecosystems occur. In this study, we focused on Odonate fauna in the “Cansiglio Forest” (Veneto, Italy), a karst area where the only checklist available dates back more than 40 years ago. To update the Odonate adult distribution in the area, we selected 21 ponds that were sampled monthly, from May to August, during a 2-year survey. In total, 21 species (belonging to 14 genera and 5 families) have been recorded: we confirmed 15 species from the previous species list and we added to the whole species list 6 new species. Dominant families were represented by Libellulidae (33%) and Aeshnidae (23%), the most common genus was Sympetrum (19%), and the most frequent species was Coenagrion puella (63%). In term of patterns of species richness, highly grazed and pastured ponds exhibited the lower number of species and individuals, as a probable response to the high level of animal disturbance on the vegetation and due to the eutrophication processes. Our results are important also in terms of conservation and management of freshwater sites belonging to Natura 2000 site.
Aerodynamic characteristic comparison of ultra-highly and normally loaded fans
Authors: Cao H. , Zhou Z.G , Ye X.L. 
Published: October 2021

ABSTRACTTo reduce fan noise and weight, according to the structural characteristics of a turbofan engine, a fan rotor with an ultra-low rotating speed is designed in this study by using a new concept of diffusion blade profiles in which the rotating speed of an ultra-highly loaded rotor is only 0.58 times that of a normally loaded rotor. To further examine the applicability of this rotor, its matching stator is also designed. The flow fields in the ultra-highly and normally loaded fan stages are simulated using the same numerical method to conduct an aerodynamic characteristic comparison. Compared with the normally loaded rotor, the sizes of the boundary layers on the blade surfaces, the wakes behind the blades and the flow losses of the ultra-highly loaded rotor are smaller. At the design point, the efficiency of the ultra-highly loaded fan stages is higher than that of the normally loaded stage; moreover, the surge margin of the former is evidently larger than that of the latter. The ultra-highly loaded fan could be a good candidate for use in Ultra-High Bypass Ratio Geared Turbofan (UHBRGT) technology.
Development of a linear-parallel and self-adaptive under-actuated hand compensated for the four-link and sliding base mechanism
Authors: Li Jianfeng , Kong Yuan , Dong Mingjie , Jiao Ran 
Published: October 2021

AbstractWhen the under-actuated hand pinches the object on the worktable, the trajectory of the end of the finger is not a straight line, which makes it difficult for the hand to grasp the object from its both sides. In order to overcome this shortcoming, this paper proposes a new configuration of the linear-parallel and self-adaptive under-actuated hand which uses the four-link and sliding base mechanism to compensate for the vertical displacement of the end of the finger. Based on this new configuration, the mechanical structure of the under-actuated hand is designed, which has five degrees of freedom (DOFs), and is mainly composed of two fingers, a sliding base, four link compensation mechanisms and an outer base. These two fingers have exactly the same structure and size, where each finger uses only one motor to control two joints of the finger which realizes the under-actuated function. Through the cooperation of the four-link and sliding base mechanism, the under-actuated hand can realize the linear-parallel and self-adaptive hybrid grasping mode. Kinematics analysis and contact force analysis of the under-actuated hand are discussed, and the prototype of the under-actuated hand is developed to carry out the grasping experiments. The results of the simulation and experiment all show that the under-actuated hand has good motion performance and grasping stability and can be used as an end effector for intelligent robots.
SECS Analysis of Nighttime Magnetic Perturbation Events Observed in Arctic Canada
Authors: Weygand James M. , Engebretson Mark J. , Pilipenko Viacheslav A. , Steinmetz Erik S. , Moldwin Mark B. , Connors Martin G. , Nishimura Yukitoshi , Lyons Larry R. , Russell Christopher T. , Ohtani Shin‐Ichi , Gjerloev Jesper 
Published: October 2021

AbstractLarge changes of the magnetic field associated with magnetic perturbation events (MPEs) with amplitudes |ΔB| of hundreds of nT and 5–10 min duration have been frequently observed within a few hours of midnight. This study compares the statistical location of nighttime MPEs with |dB/dt| ≥ 6 nT/s within the auroral current system observed during 2015 and 2017 at two stations, Cape Dorset and Kuujjuarapik, in Eastern Canada. Maps of the two dimensional nightside auroral current system were derived using the Spherical Elementary Current Systems (SECS) technique. Analyses were produced at each station for all events, and for premidnight and postmidnight subsets. We examine four MPE intervals in detail, two accompanied by auroral images, and show the varying associations between MPEs and overhead ionospheric current systems including electrojets and the field‐aligned like currents. We find 225 of 279 MPEs occurred within the westward electrojet and only 3 within the eastward electrojet. For the premidnight MPEs 100 of 230 events occurred within the Harang current system while many of the remainder occurred within either the downward region 1 current system or the upward region 2 current system. Many of the 49 postmidnight MPEs occurred in either the downward region 1 (11 events) or upward region 2 current system (27 events). These result suggest that the source of MPEs in the premidnight sector is somewhere between the inner to mid plasma sheet and the source for the MPEs in the postmidnight sector is somewhere between the inner magnetosphere and the inner plasma sheet.
Large‐Volume and Shallow Magma Intrusions in the Blackfoot Reservoir Volcanic Field (Idaho, USA)
Authors: Hastings M. S. , Connor C. B. , Wetmore P. , Malservisi R. , Connor L. J. , Rodgers M. , La Femina P. C. 
Published: October 2021

AbstractThe Blackfoot Reservoir volcanic field (BRVF), Idaho, USA, is a bimodal volcanic field that has hosted silicic eruptions during at least two episodes, as recently as 58 ka. Using newly collected ground and boat‐based gravity data, two large negative anomalies ( mGal) are modeled as shallow (  km) intrusions beneath a NE‐trending alignment of BRVF rhyolite domes and tuff rings. Given the trade‐off between density contrast and model volume, best‐fit gravity inversion models yield a total intrusion volume of ; a density contrast of kg   results in two intrusions, each km km and about 0.5 km thick, with cumulative volume of 100  . A network of trending faults lies directly above and on the margins of the mapped gravity anomalies. Most of these faults have m throw; one has throw up to m. We suggest that the emplacement of shallow sill‐like intrusions produced this fault zone and also created a ENE‐trending fault set, indicating widespread ground deformation during intrusion emplacement. The intrusions and silicic domes are located km E of a regional, 20 mGal step in gravity. We interpret this step in gravity as thickening of the Upper Precambrian to lowermost Cambrian quartzites in the Meade thrust sheet, part of the Idaho‐Wyoming Thrust Belt. Silicic volcanism in the BRVF is a classic example of volcanotectonic interaction, influenced by regional structure and creating widespread deformation. We suggest volcanic hazard assessments should consider the possibility of large‐volume silicic eruptions in the future.
Hydroclimate Correlations Between the Alxa Desert and Adjacent Mountains in Northwestern China: Evidence From Meteorological and Tree‐Ring Data
Authors: Peng Xiaomei , Yang Bao , Xiao Shengchun , Liu Jingjing , Li Gang 
Published: October 2021

AbstractIt is important to understand the hydroclimate history of water‐deficient regions, such as the Alxa desert of northwest China. However, there are few high‐resolution proxy records for the hydroclimate changes over the past centuries in the Alxa desert. Fortunately, there are many tree‐ring hydroclimate reconstructions from the nearby mountains. However, the hydroclimate correlations between the Alxa desert and adjacent mountains are unclear. Here, we collected high‐quality data from 43 meteorological stations in northwest China (1960–2017). We found increasing mean temperatures in the study area, both on seasonal and annual timescales. We also found that while relative humidity had mostly decreased in the Mt. Qilian and Alxa desert, precipitation and the standardized precipitation evapotranspiration index (SPEI) increased mostly. In the Mt. Helan and Hasi ranges, relative humidity, precipitation, and SPEI all showed decreasing trends. Empirical orthogonal function analysis indicated that precipitation, relative humidity, and SPEI in the Mt. Qilian were similar to the corresponding conditions in the central and western Alxa desert. Hydroclimate conditions in the Mt. Helan and Hasi ranges were correlated with data from the eastern desert. Tree‐ring records of precipitation and SPEI from the mountains were used to validate the hydroclimate correlations during the instrumental period. We found strong similarities between hydroclimatic changes in the Mt. Qilian and those in the central and western Alxa desert, on both annual and decadal timescales, from 1877 to 2006. Tree‐ring width chronologies from mountainous areas were shown to faithfully represent the hydroclimatic history of the desert area.
Doxorubicin-induced novel circRNA_0004674 facilitates osteosarcoma progression and chemoresistance by upregulating MCL1 through miR-142-5p
Authors: Ma Xiao-Long , Zhan Tai-Cheng , Hu Jian-Ping , Zhang Chun-Lin , Zhu Kun-Peng 
Published: October 2021

AbstractAccumulating evidence has shown that circular RNA (circRNA) dysregulation is involved in various types of cancer, including osteosarcoma (OS). Nevertheless, the role and mechanism of circRNAs in OS progression and chemoresistance remain elusive. We found that a novel doxorubicin-induced circular RNA, hsa_circ_0004674, screened by whole total transcriptome RNA sequencing in our previous study, was upregulated in OS chemoresistant cell lines and tissues and also connected with patients’ poor prognosis. Circ_0004674 knockdown remarkably suppressed OS cell chemoresistance, proliferation, migration, invasion, OS tumor growth, and enhanced cell cycle arrest and apoptosis in vitro and in vivo through control the expression of the antiapoptotic protein MCL1, a member of the Bcl-2 gene family. Further online bioinformatics analysis revealed that miR-142-5p had potential binding sites that can bind circ_0004674 and the 3′UTR of MCL1 mRNA. Moreover, the expression and function of miR-142-5p were conversely correlated with circ_0004674 in vitro. RIP, pull-down, luciferase assay, and RNA FISH demonstrated that circ_0004674 could compete with MCL1 for miR-142-5p binding to counteract miR-142-5p-mediated repression of MCL1 at the post-transcriptional level. To sum up, our study sheds light on the critical role of the oncogenic circ_0004674/miR-142-5p/MCL1 axis in OS progression and chemoresistance, providing a novel potential target for OS therapy.
Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury
Authors: Liao Suchan , Apaijai Nattayaporn , Luo Ying , Wu Jun , Chunchai Titikorn , Singhanat Kodchanan , Arunsak Busarin , Benjanuwattra Juthipong , Chattipakorn Nipon , Chattipakorn Siriporn C. 
Published: October 2021

AbstractCognitive impairment has been reported in patients with myocardial infarction despite a successful reperfusion therapy. Several modes of cell death are involved in brain damage during cardiac ischemia/reperfusion (I/R) injury. Although apoptosis, necroptosis, and ferroptosis inhibitors provided neuroprotection against cerebral I/R injury, the effects of these cell death inhibitors on the brain following cardiac I/R injury have never been investigated. We hypothesized that apoptosis, necroptosis, and ferroptosis inhibitors attenuate brain damage following cardiac I/R injury. One-hundred and twenty-six male rats were used: 6 rats were assigned to sham operation and 120 rats were subjected to 30-min regional cardiac ischemia and 120-min reperfusion. Rats in cardiac I/R group were pretreated with either vehicle (n = 12) or one of cell death inhibitors. Rats treated with apoptosis, necroptosis, or ferroptosis inhibitor were subdivided into three different doses including low (L), medium (M), and high (H) doses (n = 12/group). Z-VAD, necrostatin-1 (Nec-1), and ferrostatin-1 (Fer-1) were used as apoptosis, necroptosis, and ferroptosis inhibitor, respectively. Rats were sacrificed at the end of reperfusion, and the brain was used to analyze dendritic spine density, Alzheimer’s disease (AD)-related proteins, blood–brain barrier (BBB) tight junction proteins, mitochondrial function, inflammation, and cell death. Our data showed that cardiac I/R led to brain damage and only apoptosis occurred in the hippocampus after cardiac I/R injury. In the cardiac I/R group, treatment with M-Z-VAD and all doses of Nec-1 decreased hippocampal apoptosis and amyloid beta aggregation, thereby reducing dendritic spine loss. M- and H-Fer-1 also reduced dendritic spine loss by suppressing ACSL4, TNF-α, amyloid beta, and tau hyperphosphorylation. Moreover, Bax/Bcl-2 was decreased in all treatment regimen except L-Z-VAD. Additionally, M-Z-VAD and M-Fer-1 partially attenuated mitochondrial dysfunction. Only L-Nec-1 preserved BBB proteins. In conclusion, cell death inhibitors prevented hippocampal dendritic spine loss caused by cardiac I/R injury through different mechanisms.