bluuebunny/crossref_metadata_2025_split huggingface dataset:
Egy rendőri vezető visszaemlékezései – gondolatok a rendőri felkészítésről
Authors: Töreki Sándor 
Published: August 2021

A 21. század rendvédelmi szerveinek meg kell küzdeniük az új típusú bűncselekményekkel, fenyegetésekkel, illetve lépést kell tartaniuk az új technológiákkal, valamint az újonnan formálódó közösségekkel, amelyek mindegyike új kihívásként, s egyúttal új lehetőségként jelentkezik. A közvélemény elvárásai megváltoztak, és a közbiztonsági „aréna” manapság jóval több érdekeltet vonultat fel, akikkel a rendőrségnek együtt kell működnie a helyben és globálisan jelentkező összetett kérdések megoldása céljából. Annak érdekében, hogy megfeleljenek a társadalom elvárásainak, a rendőrségnek kvalifikált munkatársakra és egy olyan képzési rendszerre van szüksége, amely képes gyorsan és intelligensen válaszolni a társadalmi, tudományos és technikai változásokra. A fentiek eredményeként a rendvédelmi szervek vezetésének ugyancsak idomulnia és fejlődnie kell. Fokozódó elvárás a rendőri vezetők felé, hogy oly módon működtessék a szervezetet, amelynek révén az hatékonyan és az állampolgárok megelégedésére látja el feladatát.
A Rendőrtiszti Főiskola múltjáról, jelenéről és jövőjéről
Authors: Nyerges Lajos 
Published: August 2021

A főiskola történetét majd valószínűleg meg fogják írni. Én az egyszerűbb utat választottam. Beszélgetésre hívtam meg a főiskola egyik megalapítóját, Györök Ferencet és a jelenlegi főigazgatót, Kratochwill Ferencet. Szembesíteni akartam a múltat a jelennel, és arra számítottam, hogy a kérdéseim nyomán vita alakul ki közöttük. Nem ez történt. Az alapvető kérdésekben egyetértettek, ami azt jelenti, hogy a fejlődés törvényének megfelelően a főiskola betölti a funkcióját: magas színvonalon rendőrtiszteket oktat és nevel.
The Enhancement of Face-To-Face Reading skill at the University of Tabuk Using Internet-Based Reading Activities
Authors: Alshaikhi Turky E. 
Published: August 2021

This study aimed to investigate how far internet-based reading activities can enhance learners’ reading skills in face-to-face learning experience at the faculty of education and arts, University of Tabuk in Saudi Arabia, for the Academic Year 2021. This study also examined students' learning preferences, experiences, and participation in traditional and non-traditional classrooms as blended learning has come in vogue at the university due to Covid19 restrictions. This quantitative research consisted of 90 university EFL learners from the faculty of education and arts at Tabuk University. The study employed descriptive statistics to analyze learners’ responses. The findings showed that internet-based reading activities and peer moderated discussions could enhance learners’ reading skills in the face-to-face EFL classes at the university. Internet-based reading activities also led to greater language output in the other three language skills viz., speaking, listening and writing when these are undertaken in the physical mode. However, gaps exist in their application to student learning preferences and whether they match student preferences for reading activities. Limited literature is existed on following up internet-based reading activities with physical learning in traditional classrooms. A single overarching research question guided this study: How far can the innovative method of internet-based reading enhance learners’ reading in face-to-face learning environments. The results proved encouraging drills as the previously challenging reading drills were perceived as engaging by the learners after the brief intervention. However, whether the results are temporal or reliable can only be ascertained with larger samples and varied learning environments.
Effective Language Teaching and Learning Process in EFL Classroom Situation: A Case Study
Authors: BENZERROUG Samah 
Published: August 2021

The goal of teaching and learning a foreign language, in general, has shifted from putting emphasis on the product of teaching to the process of teaching and learning and the accompanying classroom conditions. This development in foreign language teaching pedagogy stresses the importance of the classroom environment in enhancing the individual’s learning styles and motivation to acquire the language, skills and components. Therefore, it is essential that every language class is directed to equip the learners with the necessary language strategies to achieve language proficiency by considering their needs and interests. This is why, teachers are always looking for updated ways and techniques to develop the student competencies in listening, speaking reading, writing, vocabulary and grammar. In this context, the present research was conducted more specifically to examine to what extent can the role of the teacher and the quality of the teaching and learning process be effective in developing the learners’ skills and competencies and promoting the EFL classroom situation. In addition, the different pedagogical tools and phases that are implemented in English language teaching in the Algerian school will be presented and analyzed in this paper.
Teachers’ Attitudes towards Online Writing Assessment during Covid-19 Pandemic
Authors: Anasse Khadija , Rhandy Rajaa 
Published: August 2021

The COVID-19 pandemic has imposed an abrupt change in our teaching practices. Particularly the online assessment of students’ writing has been an unprecedented, novel situation for many English foreign language teachers. What is novel about this issue is the constraint of adopting it in a critical situation in which it has been an alternative way to assess students in the absence of the physical presence of students. The shift from face to face assessment to online assessment has been a novel experience for many Moroccan English foreign language teachers who have never implemented it before nor have any background knowledge about its mechanisms and methods albeit there are some teachers who are familiar with online teaching and online assessment. The issue has generated important points for English language teaching practitioners and stakeholders about the strategies and challenges of this compulsory mode of assessment during COVID-19 lockdown. From this perspective, the purpose of this paper was to reflect on writing assessment in the era of COVID-19 pandemic through the lens of teachers. The paper aimed to explore the perceptions of Moroccan English foreign language teachers about online writing assessment and the challenges that encountered them. For this purpose, data were collected from 100 English language teachers in the region of Casablanca through the use of questionnaires. The findings of this study substantiated that most participants considered online assessment of students’ writing a real challenge and hence hold a negative attitude towards it. Based on the results of this study, it was recommended to teach digital writing skills to English foreign language learners and design teaching training programs about online writing assessment.
Data-Intensive Experimental Linguistics
Authors: Abney Steven 
Published: August 2021

Computational linguistics is not a specialization of linguistics at all; it is a branch of computer science. A large majority of computational linguists have degrees in computer science and positions in computer science departments. It was founded as an offshoot of an engineering discipline (machine translation), and has been subsequently shaped by its place within artificial intelligence, and by a heavy influx of theory and method from speech recognition (another engineering discipline) and machine learning.
But computation is a means to an end; the essential feature is data collection, analysis, and prediction on the large scale. I will call it data-intensive experimental linguistics.
I wish to explain how data-intensive linguistics differs from mainstream practice, why I consider it to be genuine linguistics, and why I believe that it enables fundamental advances in our understanding of language.
Análisis de integrales trigonométricas notables
Authors: Insuasti Castelo Rómel Manolo , Mendoza Castillo Javier Roberto 
Published: August 2021

Introducción. El cálculo de integrales trigonométricas es un proceso que reviste el empleo de algunas técnicas de integración, para esto se debe tener claro los procedimientos a seguir y ser muy observador al elegir la técnica de integración apropiada. Objetivo. Se desea simplificar el cálculo de la integral trigonométrica notable. Metodología. Para entender esta metodología es necesario conocer algunos conceptos que están alrededor de las funciones trigonométricas a integrar, como son la periodicidad de una función , su paridad (función par o impar), y que las integrales estén evaluadas en los límites correspondientes a los intervalos de la periodicidad, a este tipo de integrales las denominaremos integrales notables pues no es estrictamente necesario evaluarlas por procesos de integración sino que se deducen su resultado a partir de los conceptos antes mencionados. Resultados. Si bien es cierto que las integrales mencionadas se las pueden encontrar resueltas, la intención de este análisis es mostrar que el resultado de estas integrales es fácil recordar en comunión de los conceptos citados de manera mecánica y sencilla.
Rancang Bangun Sistem Informasi Penggajian Dosen Berbasis Web
Authors: Mulyani Asri , Kurniadi Dede , Rima Fauziyah Siti 
Published: August 2021

Dengan adanya sistem ini dapat memberikan kemudahan dalam pengelolaan data penggajian, pembuatan slip gaji, pembuatan laporan penggajian dapat membantu dalam perhitungan gaji serta menghindari resiko-resiko yang dapat menghambat dalam proses pengelolaan penggajian. Dalam penelitian ini menggunakan metodologi Rational Unified Process (RUP). Rational Unified Process merupakan proses rekayasa perangkat lunak yang menyediakan pendefinisian struktur yang baik untuk alur hidup proyek perangkat lunak. Tahapan metodologi ini meliputi inception, elaboration, construction dan transition serta dimodelkan dengan Unified Modelling Language (UML). Hasil dari penelitian ini adalah sistem informasi penggajian dosen berbasis web yang dapat digunakan oleh pengelola keuangan di intansi tersebut. Pengujian hasil dari penelitian ini menggunakan metode blackbox testing yang merupakan cara uji coba perangkat lunak pada sistem informasi yang berfokus pada spesifikasi fungsional dari perangkat lunak sistem informasi yang sudah dibangun.
A Retrospective Analysis of the Clinical Studies of a Drug "Flakozid" in the Treatment of Diseases of the Hepatobiliary System
Authors: Bortnikova V. V. , Karabaeva V. V. , Krepkova L. V. , Mizina P. G. , Babenko A. N. , Mikheeva N. S. , Karabaeva O. N. 
Published: August 2021

Introduction. The medicine "Flakozid" with hepatoprotective effect has been developed at the VILAR. The drug is presented in dosage form-tablets of 0.1 g for oral drug administrationAim. To analyze the clinical efficacy and safety of "Flakozid" therapy according to clinical laboratory methods, as well as the motility of the gallbladder and bile ducts in patients with diseases of the hepatobiliary system.Materials and methods. The results of clinical studies of "Flakozid" (0.1 g tablets) were analyzed in 99 patients with chronic active hepatitis, chronic stone-free cholecystitis and fatty liver dystrophy, conducted in 2 clinical institutions: Perm State Medical University. Academician E. A. Wagner of the Ministry of Health of Russia and the Central Research Institute of Gastroenterology. "Flakozid" was prescribed against the background of a therapeutic diet (Table No. 5) of 0.1-0.2 g 3 times a day after meals for 32 days and repeated courses (3-5) for 6-12 months. Analysis of the efficacy and safety of "Flakozid" was carried out on the basis of the results of clinical and laboratory studies: general and biochemical blood analysis, general urinalysis, electrocardiogram. To study the motility of the gallbladder and biliary tract, the method of multifractional duodenal probing was used to determine the functional state of the sphincter apparatus of the gallbladder and biliary tract. In cystic and hepatic bile, its biochemical composition was determined. All patients underwent X-ray examination of the gastrointestinal tract, liver scanning and hepatography with iodine-131-bengal-roz.Results and discussion. In chronic active hepatitis, chronic stone-free cholecystitis and fatty liver dystrophy the use of "Flakozid" orally in daily doses of 0.3-0.6 g for 25-45 days led to an improvement in the General condition of patients, a decrease in pain in the right hypochondrium, a decrease in dyspeptic disorders, and an improvement in appetite. According to cholecystography, the indicators of concentration and contractility of the gallbladder improved. In terms of the severity of the therapeutic effect, "Flakozid" was not inferior to silibor and carsil, and in some indicators (improvement of the motility of the gallbladder and biliary tract) significantly exceeded them.Conclusions. Treatment of "Flakozid" improved functional state of the liver, reducing the syndrome of cytolysis and cholestasis. "Flakozid" is recommended in clinical practice in the complex treatment of diseases of the hepatobiliary system, such as chronic active hepatitis, chronic stone-free cholecystitis and fatty liver dystrophy.
Determination of Lappaconitin, Diterpene Alkaloide Obtained from Plants <i>Aconitum leucostomum</i>, and its Active Metabolite N-desacetyllappaconitin in Human Plasma and Blood
Authors: Archakova O. A. , Komarov T. N. , Rogov A. V. , Shchelgacheva D. S. , Aleshina A. A. , Bagaeva N. S. , Shohin I. E. 
Published: August 2021

Introduction. Lappaconitine is an alkaloid, contained into Aconitum leucostomum Vorosh. roots and herbs. The alkaloid is indicated to arrhythmia. The lappaconitine drugs are metabolized into eight pharmacologically active substances, but N-desacetyllappaconitine is the most effective. Drugs based on a lappaconitine has narrow therapeutic range and many kinds of side effects. Pharmacokinetics of lappaconitine should be more studied for safety medical use of lappaconitine drugs.Aim. The aim of this study is to develop method for the quantitative determination of lappaconitine and its active metabolite N-desacetyllappaconitine in human plasma and blood by high performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS). Materials and methods. Determination of lappaconitine and N-desacetyllappaconitine in plasma and blood was carried out by HPLC-MS/MS. The samples were processed by acetonitrile protein precipitation.Results and discussion. This method was validated by next parameters: selectivity, matrix effect, calibration curve, accuracy, precision, spike recovery, lower limit of quantification, carry-over effect and stability.Conclusion. The method of the quantitative determination of lappaconitine and N-desacetyllappaconitine in human plasma and blood was developed and validated by HPLC-MS/MS. The analytical range of the was 0.50-50.00 ng/ml for lappaconitine and 0.50-100.00 ng/ml for N-desacetyllappaconitine in biological matrix. Method could be applied to determination of lappaconitine and N-desacetyllappaconitine for PK studies.
Scaling of the Granulation Process in the Conditions of GMP Training Center and Assessment of Possible Risks
Authors: Abrosimova O. N. , Burakova M. A. 
Published: August 2021

Introduction. The stage of wet granulation is often used in the technology of solids. The method of wet granulation in a mixer-granulator with high shear force can be regarded as the most complicated method of its implementation from the engineering and technological point of view. The mixer-granulator has two mixers located in mutually perpendicular planes. Using an impeller, dry components are mixed, and the chopper, turning on when spraying a humidifier, ensures the formation of granules. By setting different chopper rotational speed, granules of different sizes can be obtained. This granulator has the following advantages: it provides a high product yield (≥ 99 %), takes up small workspaces, and the closed design ensures environmental protection.Aim. The aim of the research is to scale the granulation process, on the example of the solids production technology, using the wet granulation stage - in a mixer-granulator with high shear force.Materials and methods. Dry extract «N» and auxiliary substances were used as a pharmaceutical substance: lactose monohydrate, microcrystalline cellulose (MCC) (MICROCEL® MC-102), potato starch, povidone (Plasdone™ K-29/32), calcium stearate. Granulate under scaling conditions was produced in a mixer-granulator with high shear force. Technological properties of dry extract «N» and granulate were determined by the methods described in National pharmacopeia XIV.Results and discussion. On the basis of experimental studies, it was found that the resulting granulate, both when obtained under laboratory conditions and under scaling conditions, has good flowability, and also has a homogeneous fractional composition. The presence of a grinder in the mixer-granulator made it possible to obtain a more uniform fractional composition of the granulate. A 10-fold increase in loading did not affect the composition of the granulate. When scaling the pelletizing process, a risk analysis was carried out, factors influencing the technological process were identified and structured. It turned out that the most important stages are mixing and the actual granulation. To obtain a homogeneous mixture, additional equipment was used - a mixer.Conclusion. As a result of scaling up the granulation process, the parameters of wet granulation in the mixer-granulator (optimal loading, impeller and grinder rotation frequency), technological properties of the resulting granulate, and risks affecting the technological process were selected. were evaluated and a causal diagram (Ishikawa diagram) was drawn.
Procedure for Reviewing Pharmaceutical Inspections in the Eurasian Economic Union (Review)
Authors: Meshkovskiy A. P. , Beregovykh V. V. , Shestakov V. N. , Pyatigorskaya N. V. , Aladysheva Zh. I. , Nikolenko N. S. , Pyatigorskiy A. M. , Nesterkina E. I. 
Published: August 2021

Introduction. The article discusses significant changes in the procedure for pharmaceutical inspection of drug manufacturers for compliance with the requirements of the rules of good manufacturing practice (GMP) of the Eurasian Economic Union (EAEU), related to restrictions due to the COVID-19 pandemic.Text. The article presents the main international guidelines describing the remote conduct of pharmaceutical inspections, which is the basis for further updating the relevant procedures in the law of the EAEU. An overview of the foreign practice of pharmaceutical inspection during the pandemic is given. In addition, the changes in the Russian regulatory approaches to control and supervision in the Russian legislation are presented.Conclusion. These data give an idea that, with considering the above, there is a need for further convergence of the requirements, the practice of conducting pharmaceutical inspections for compliance with the requirements of GMP Rules in order to harmonize the norms between Russian regulatory documents, the norms of the EAEU law and international standards. This requires the development of a dialogue with the participation of stakeholders.
Biomedical Applications of Silver Nanoparticles (Review)
Authors: Rejepov D. T. , Vodyashkin A. A. , Sergorodceva A. V. , Stanishevskiy Ya. M. 
Published: August 2021

Introduction. Silver nanoparticles have unique physicochemical properties and can be used for the diagnosis and treatment of various kinds of infections, oncological diseases, as well as drug delivery. The review presents an analysis of scientific literature on the use of silver nanoparticles for biomedical purposes.Text. The review discusses the perspectives of the silver nanoparticles use in the treatment of oncological diseases as a carrier of drugs, as well as the direct manifestation of their cytotoxic effect on cancer cells. Also, there is considered the use of silver nanoparticles for imparting or enhancing the antibacterial effects of dressings and dental materials. The mechanism of action of silver nanoparticles against viruses is considered. This research presents the use of composite materials containing silver nanoparticles for biomedical purposes.Conclusion. On the basis of the literature data analysis, carried out by the authors, there are shown possibilities of the nanotechnology achievements for the application in medicine.
Use of High Performance Liquid Chromatography in the Analysis of a New Substance VMA-10-18
Authors: Mischenko E. S. , Lazaryan J. S. , Lazaryan A. Jh. 
Published: August 2021

Introduction. Quinazoline derivatives have a wide range of pharmacological properties, which makes this group quite unique among other classes of heterocyclic compounds. Substance VMA-10-18, which has cerebrovasodilating, antidepressant, anxiolytic and nootropic properties, may become a promising new drug. In this regard, an urgent task is to develop methods for standardizing this substance.Aim. Development of a method for the quantitation of related impurities of a new biologically active substance VMA-10-18 (Quinazophene) by HPLC with subsequent statistical processing of the results.Materials and methods. To develop the conditions for chromatographic analysis, was used a highly purified substance 3-[2-(4-methoxyphenylamino)-2-oxoethyl]-quinazolin-4(3H)-one, as well as its related impurities: impurity I (unsubstituted quinazolin-4(3H)-one) and impurity II (4-methoxychloroacetanilide). Test solutions were prepared using volumetric glassware of accuracy class 1. Ethyl alcohol 95 % was used as a solvent. Chromatography was performed using a Dionex UltiMate 3000 system (Dionex, United States) with a spectrophotometric detector. The analysis was carried out at a wavelength of 231 nm. Data collection and processing was carried out using the Chromeleon v.7 system. A mixture of acetonitrile and orthophosphoric acid was used as a mobile phase. The analysis was performed in an isocratic mode. The validation of the developed method was carried out taking into account the requirements of the State Pharmacopeia of Russian Federation XIV edition and the recommendations of the ICH.Results and discussion. The optimal conditions for chromatography of the VMA-10-18 substance and its impurities have been developed. It was found that for a clear separation of the peaks of the substance and impurities among themselves, the mobile phase should contain acetonitrile and orthophosphoric acid in a ratio of 80 : 20. The specificity of the method was determined by chromatography of ethyl alcohol in order to exclude its influence on the analysis results. The linearity and correctness of the method were determined at 7 levels of concentration of impurities of the substance. The correlation coefficient has exceeded 0.99. Also, the free term of the linear dependence equation (a) for both impurities was less than its confidence interval (Δа), which proves the absence of a systematic error of the method. When determining the "Convergence" indicator, the calculated relative standard deviation did not exceed 2 %. When determining the intralaboratory precision, Student's t-test and Fisher's F-test were calculated. Both indicators met the stated requirements.Conclusion. A method for the quantitative determination of impurities in the VMA-10-18 substance by HPLC has been developed and validated.