bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multimodality Machine Learning Approach to Differentiate Severe and Nonsevere COVID-19: Model Development and Validation
Authors: Chen Yuanfang , Ouyang Liu , Bao Forrest S , Li Qian , Han Lei , Zhang Hengdong , Zhu Baoli , Ge Yaorong , Robinson Patrick , Xu Ming , Liu Jie , Chen Shi 
Published: March 2021

Background
Effectively and efficiently diagnosing patients who have COVID-19 with the accurate clinical type of the disease is essential to achieve optimal outcomes for the patients as well as to reduce the risk of overloading the health care system. Currently, severe and nonsevere COVID-19 types are differentiated by only a few features, which do not comprehensively characterize the complicated pathological, physiological, and immunological responses to SARS-CoV-2 infection in the different disease types. In addition, these type-defining features may not be readily testable at the time of diagnosis.

Objective
In this study, we aimed to use a machine learning approach to understand COVID-19 more comprehensively, accurately differentiate severe and nonsevere COVID-19 clinical types based on multiple medical features, and provide reliable predictions of the clinical type of the disease.

Methods
For this study, we recruited 214 confirmed patients with nonsevere COVID-19 and 148 patients with severe COVID-19. The clinical characteristics (26 features) and laboratory test results (26 features) upon admission were acquired as two input modalities. Exploratory analyses demonstrated that these features differed substantially between two clinical types. Machine learning random forest models based on all the features in each modality as well as on the top 5 features in each modality combined were developed and validated to differentiate COVID-19 clinical types.

Results
Using clinical and laboratory results independently as input, the random forest models achieved >90% and >95% predictive accuracy, respectively. The importance scores of the input features were further evaluated, and the top 5 features from each modality were identified (age, hypertension, cardiovascular disease, gender, and diabetes for the clinical features modality, and dimerized plasmin fragment D, high sensitivity troponin I, absolute neutrophil count, interleukin 6, and lactate dehydrogenase for the laboratory testing modality, in descending order). Using these top 10 multimodal features as the only input instead of all 52 features combined, the random forest model was able to achieve 97% predictive accuracy.

Conclusions
Our findings shed light on how the human body reacts to SARS-CoV-2 infection as a unit and provide insights on effectively evaluating the disease severity of patients with COVID-19 based on more common medical features when gold standard features are not available. We suggest that clinical information can be used as an initial screening tool for self-evaluation and triage, while laboratory test results should be applied when accuracy is the priority.
Multimodal Recruitment to Study Ovulation and Menstruation Health: Internet-Based Survey Pilot Study
Authors: Mahalingaiah Shruthi , Cheng J Jojo , Winter Michael R , Rodriguez Erika , Fruh Victoria , Williams Anna , Nguyen MyMy , Madhavan Rashmi , Karanja Pascaline , MacRae Jill , Konanki Sai Charan , Lane Kevin J , Aschengrau Ann 
Published: March 2021

Background
Multimodal recruitment strategies are a novel way to increase diversity in research populations. However, these methods have not been previously applied to understanding the prevalence of menstrual disorders such as polycystic ovary syndrome.

Objective
The purpose of this study was to test the feasibility of recruiting a diverse cohort to complete a web-based survey on ovulation and menstruation health.

Methods
We conducted the Ovulation and Menstruation Health Pilot Study using a REDCap web-based survey platform. We recruited 200 women from a clinical population, a community fair, and the internet.

Results
We recruited 438 women over 29 weeks between September 2017 and March 2018. After consent and eligibility determination, 345 enrolled, 278 started (clinic: n=43; community fair: n=61; internet: n=174), and 247 completed (clinic: n=28; community fair: n=60; internet: n=159) the survey. Among all participants, the median age was 25.0 (SD 6.0) years, mean BMI was 26.1 kg/m2 (SD 6.6), 79.7% (216/271) had a college degree or higher, and 14.6% (37/254) reported a physician diagnosis of polycystic ovary syndrome. Race and ethnicity distributions were 64.7% (176/272) White, 11.8% (32/272) Black/African American, 7.7% (21/272) Latina/Hispanic, and 5.9% (16/272) Asian individuals; 9.9% (27/272) reported more than one race or ethnicity. The highest enrollment of Black/African American individuals was in clinic (17/42, 40.5%) compared to 1.6% (1/61) in the community fair and 8.3% (14/169) using the internet. Survey completion rates were highest among those who were recruited from the internet (159/174, 91.4%) and community fairs (60/61, 98.4%) compared to those recruited in clinic (28/43, 65.1%).

Conclusions
Multimodal recruitment achieved target recruitment in a short time period and established a racially diverse cohort to study ovulation and menstruation health. There were greater enrollment and completion rates among those recruited via the internet and community fair.
The Patterns and Impact of Social Media Exposure of Journal Publications in Gastroenterology: Retrospective Cohort Study
Authors: Chiang Austin Lee , Rabinowitz Loren Galler , Alakbarli Javid , Chan Walter W 
Published: March 2021

Background
Medical journals increasingly promote published content through social media platforms such as Twitter. However, gastroenterology journals still rank below average in social media engagement.

Objective
We aimed to determine the engagement patterns of publications in gastroenterology journals on Twitter and evaluate the impact of tweets on citations.

Methods
This was a retrospective cohort study comparing the 3-year citations of all full-length articles published in five major gastroenterology journals from January 1, 2012, to December 31, 2012, tweeted by official journal accounts with those that were not. Multivariate analysis using linear regression was performed to control for journal impact factor, time since publication, article type, frequency of reposting by other users (“retweets”), and media addition to tweets. Secondary analyses were performed to assess the associations between article type or subtopic and the likelihood of social media promotion/engagement.

Results
A total of 1666 articles were reviewed, with 477 tweeted by the official journal account. Tweeting an article independently predicted increased citations after controlling for potential confounders (β coefficient=13.09; P=.007). There was significant association between article type and number of retweets on analysis of variance (ANOVA) (P<.001), with guidelines/technical reviews (mean difference 1.04, 95% CI 0.22-1.87; P<.001) and meta-analyses/systemic reviews (mean difference 1.03, 95% CI 0.35-1.70; P<.001) being retweeted more than basic science articles. The manuscript subtopics most frequently promoted included motility/functional bowel disease (odds ratio [OR] 3.84, 95% CI 1.93-7.64; P<.001) and education (OR 4.69, 95% CI 1.62-13.58; P=.004), while basic science papers were less likely tweeted (OR 0.154, 95% CI 0.07-0.34; P<.001).

Conclusions
Tweeting of gastroenterology journal articles independently predicted higher 3-year citations. Wider adoption of social media to increase reach and measure uptake of published research should be considered.
EL margen, la violencia y sus fronteras
Authors: Mastronardi Bárbara 
Published: March 2021

En este artículo analizo crónicas y fotografías publicadas en los diarios Clarín y La Nación que representan a la figura del joven, varón y pobre y a los territorios que habitan en relación a la violencia durante el período 2004 – 2014. Para ello, parto de una perspectiva metodológica que realiza un cruce analítico entre antropología, semiótica y análisis cultural. Entre los resultados de esta investigación se encuentran la deconstrucción del lugar de enunciación desde donde se muestran a estos sujetos y territorios, la identificación de metáforas que funcionan como organizadoras en la delimitación y marcación de fronteras y la descripción de los elementos – signos que convierten a estos sujetos y territorios en objeto de representación. La conclusión es que estas operaciones y mecanismos discursivos colaboran en la co-producción de una imagen estigmatizada y criminalizante que reproduce los mecanismos de legitimación de la desigualdad social.
Discurso de derecha y resistencia frente al cambio constitucional
Authors: Alarcón Silva Mauricio Esteban , Godoy Berthet Carolina Andrea 
Published: March 2021

En medio del estallido social, Chile logra un acuerdo político que determina una consulta ciudadana para decidir sobre el cambio de constitución vigente desde la dictadura militar. La consulta, fijada inicialmente para el 26 de abril de 2020, encuentra al país en una polarización ideológica sustentada en la posible afectación a los pilares del modelo neoliberal, su constitución.
El presente trabajo aborda el discurso de derecha a partir de un caso de propaganda electoral a favor de la opción Rechazo el cambio. Analiza el discurso en su dimensión ideológica, también aborda recursos multimodales que son analizados mediante semiótica visual y metáfora multimodal.
Se evidencia la construcción de un nosotros (Rechazo) que valora el orden y la capacidad de elegir y soñar un país, que se distancia de un otros que engaña sobre una posible mayoría que se manifiesta en las calles. A través de elementos metafóricos apela a la amenaza de un enemigo con intenciones ocultas, representando a los políticos que usufructúan sin mayor esfuerzo de la democracia, en definitiva, tras el llamado a votar rechazo, un discurso coherente con las descripciones teóricas, que junto con restar valor a la participación, construye ideológicamente un enemigo al que se debe temer.
Prensa y conflicto por la tierra en áreas periurbanas
Authors: Melo Luciana Catalina 
Published: March 2021

En 1998 el Parque Pereyra Iraola (PPI) (Provincia de Buenos Aires) fue escenario de un conflicto por la tenencia de la tierra entre los quinteros del PPI y el gobierno provincial. Este derivó en el despliegue de un gran operativo de las fuerzas de seguridad con el objetivo de expulsar a los quinteros. La prensa local se hizo eco de ello, principalmente diarios como Hoy en la noticia (Hoy), El Dia ( La Plata) y El Sol (Quilmes).
El objetivo de este artículo es interpretar la postura de estos medios de prensa acerca del conflicto, en el que intervinieron una gran cantidad de actores sociales.
Nonlinear Mathematical Modelling of Bone Damage and Remodelling Behaviour in Human Femur
Authors: Bu Rui , Qu Chuanyong , Sánchez Yolanda Guerrero 
Published: March 2021

Abstract
The simulation of bone remodelling is highly complex due to the high nonlinear coupled relations between the damage and repair behaviours. In this paper, a new bone remodelling model based on the fatigue damage mechanism is proposed. Then the repair process of the human femur is simulated based on the finite element method. The results show that the new damage model can well simulate the bone damage evolution caused by overloadings. This indicates that the new mathematical model suggested in this paper can simulate the effect of external load on the cortical bone density and the related mechanical properties of the cortical bone.
Economical and Social Dimensions of Unionization in Turkish Textile and Clothing Sector
Authors: Kanat Seher , Atılgan Turan , Küçük Pelin Ofluoğlu 
Published: March 2021

Abstract
Textile and clothing sector possesses a significant place in Turkish manufacturing industry as well as in exports, investments, gross national product and employment; also maintains its locomotive sector position in development for a long time with its established production potential and labor force. However, there are serious issues about the unionization of workers in the sector. On one hand, this situation causes an increment in social and economical issues of workers and enterprises and on the other hand, it damages democracy within the enterprise. In this context, this study aims to suggest tangible solutions by revealing the economical and social differences between unionization and non-unionization in the sector. Besides, the study differs from other studies and contributes to the literature due to its two-sided research structure (workers and employers) and analysis of unionization in textile and clothing sector in terms of economical and social aspects. In accordance with the aim of the research, two separate surveys are conducted for textile and clothing enterprises, which operate throughout Turkey, and for unionized and non-unionized blue-collar workers of these enterprises. The obtained data are analyzed by using descriptive statistics, exploratory factor analysis, and independent samples t-test. As stated by the research results, the perspectives of unionized and non-unionized participants differ with regard to positive and negative aspects (both economical and social aspects) of being a union member.
On the Forms and Thorns of Linguistic Indeterminacy in Chinese Law
Authors: Mannoni Michele 
Published: March 2021

Abstract
This study addresses the different types and implications of linguistic indeterminacy in Chinese law. It firstly draws on the studies of scholars of different disciplines, such as linguistics and philosophy of language, to provide a taxonomy of indeterminacy in language. It then provides examples of each type, highlighting the implications in law and legal interpretation. It uses linguistic data from various texts, such as statutory laws and judgements, and analyses them with various methods, including discourse analysis and corpus linguistics. This study argues that when the language of the law is indeterminate, the legal outcomes may be particularly uncertain. It suggests that although it is difficult to ascertain whether the degree of indeterminacy is higher in some languages more than in others, some linguistic mechanisms at the word-formation level in Chinese, such as portmanteaus and the modifier-modified structure, are remarkably ambiguous. When uncertain terms are in key parts of the law, the consequences may be more serious. The study of linguistic indeterminacy in Chinese has implications for the study of forensic linguistics, and Chinese studies in general.
Investigation of E-Cigarette Smoking Model with Mittag-Leffler Kernel
Authors: Uçar Esmehan , Uçar Sümeyra , Evirgen Fırat , Özdemir Necati 
Published: March 2021

Abstract
Smoking is the most lethal social poisoning event. The World Health Organization defines smoking as the most important preventable cause of disease. Around 4.9 million people worldwide die from smoking every year. In order to analysis this matter, we aim to investigate an e-cigarette smoking model with Atangana-Baleanu fractional derivative. We obtain the existence conditions of the solution for this fractional model utilizing fixed-point theory. After giving existence conditions, the uniqueness of the solution is proved. Finally, to show the effect of the Atangana-Baleanu fractional derivative on the model, we give some numerical results supported by illustrative graphics.
The need for a coordinated action to elucidate ecological occurrence and functions of endophytic fungal communities
Authors: Nicoletti Rosario , Vinale Francesco 
Published: March 2021

Abstract
Research concerning endophytic fungi has recently received a remarkable boost following a general trend to investigate and exploit biodiversity in all its forms, and because of the easier access to equipment and methods, which enables quicker identification procedures. The available data highlight that, besides the plant hosts, endophytes consistently interact with the other components of biocoenosis, and that the assortment of the microbial consortium is also to be considered on account of the reciprocal influence between the several species which are part of it. Unravelling these complex ecological relationships is fundamental because of possible translational applications, particularly regarding crop management. However, this requires that the available information concerning plant species, ecological contexts or functional categories of endophytes is examined fully. In this aim, a coordinated effort appears to be necessary to organise the current knowledge to increase the significance and the practical impact of new findings.
Epigenetic markers associated with schistosomiasis
Authors: Gomes Assenço R. A. , Alves Mota E. , De Oliveira V. F. , De Castro Borges W. , Guerra-Sá R. 
Published: March 2021

Summary
It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of 1. Egg detection in the stool or urine by microscopy remains with limited sensitivity; 2. Immunological screening, in which positivity persists after treatment, and 3. Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.
Competitive spirit as a form of behavioral addiction: the case study of Michael Jordan
Authors: Jacheć Tomasz 
Published: March 2021

Abstract
When studying biographical narratives constituting “The Michael Jordan Myth,” certain patterns emerge. For example, it is possible to identify mythemes corresponding with Campbell’s concept of the hero’s journey monomyth. This study focuses on a particular pattern, which is a progression of addiction with its phases, axial points, and list of symptoms. One of the most frequently used epithets in regard to the hero of this particular myth is “competitive.” While this is a quality of numerous outstanding athletes, in Jordan’s case competitiveness appears as a dominant quality and a driving force throughout his entire career.
The premise of my study is the assumption that Jordan’s competitive spirit is a symptom of behavioral addiction and winning/defeating rivals is the behavior of an addict. The goal of the study is to use Jordan’s biographies and, based on Jellinek’s model of addiction progression, to verify whether Jordan’s accomplishments on and off the court can be viewed as symptoms of unclassified behavioral addiction.
Sepiolite-based adsorbents for carbon dioxide capture
Authors: Szymańska Alicja , Kiełbasa Karolina 
Published: March 2021

Abstract
Sepiolite and the sepiolite-based materials were studied in terms of carbon dioxide adsorption. The pore structure and the surface characterization of the obtained materials were specified based on adsorption-desorption isotherms of nitrogen measured at –196oC and carbon dioxide at 0oC. The specific surface area (SSA) was calculated according to the BET equation. The pore volume was estimated using the DFT method. Pristine sepiolite has shown the following value of SSA and CO2 uptake at 0oC – 105 m2/g and 0.27 mmol/g, respectively. The highest value of these parameters was found for material obtained by KOH activation of mixture sepiolite and molasses (MSEP2) – 676 m2/g and 1.49 mmol/g. Sample MSEP2 also indicated the highest value of total pore volume and micropores volume with a diameter up to 0.8 nm.
Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer
Authors: Merlo Sebastjan , Besic Nikola , Drmota Eva , Kovacevic Nina 
Published: March 2021

Abstract

Background
Ovarian cancer is the seventh most common cancer in women worldwide and the eighth most common cause of cancer death. Due to the lack of effective early detection strategies and the unspecific onset of symptoms, it is diagnosed at an advanced stage in 75% of cases. The cancer antigen (CA) 125 is used as a prognostic marker and its level is elevated in more than 85% of women with advanced stages of epithelial ovarian cancer (EOC). The standard treatment is primary debulking surgery (PDS) followed by adjuvant chemotherapy (ACT), but the later approach is neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). Several studies have been conducted to find out whether preoperative CA-125 serum levels influence treatment choice, surgical resection and survival outcome. The aim of our study was to analyse experience of single institution as Cancer comprehensive center with preoperative usefulness of CA-125.

Patients and methods
At the Institute of Oncology Ljubljana a retrospective analysis of 253 women with stage FIGO IIIC and IV ovarian cancer was conducted. Women were divided into two groups based on their primary treatment. The first group was the NACT group (215 women) and the second the PDS group (38 women). The differences in patient characteristics were compared using the Chi-square test and ANOVA and the Kaplan-Meier method was used for calculating progression-free survival (PFS) and overall survival (OS).

Results
The median serum CA-125 level was higher in the NACT group than in the PDS group, 972 IU/ml and 499 IU/ ml, respectively. The PFS in the NACT group was 8 months (95% CI 6.4–9.5) and 18 months (95% CI 12.5–23.4) in the PDS group. The median OS was lower in the NACT group than in the PDS group, 25 months (95% CI 20.6–29.5) and 46 months (95% CI 32.9–62.1), respectively.

Conclusions
Preoperative CA-125 cut off value of 500 IU/ml is a promising threshold to predict a successful PDS.
Does Renewable Energy Matter for Economic Growth in Central and Eastern European Countries? Empirical Evidence from Heterogeneous Panel Cointegration Analysis
Authors: Neagu Olimpia , Haiduc Cristian , Anghelina Andrei 
Published: March 2021

Abstract
The aim of the paper is to provide empirical evidence in support of the relationship between renewable energy consumption and economic growth in eleven Central and Eastern European (CEE) countries over the period 1995-2015 within a multivariate panel data analysis. Based on World Bank data, the panel cointegration analysis reveals that renewable energy consumption and economic growth are positively associated in the long run in CEE countries. The heterogeneous panel causality test indicates a bi-directional causality relationship in support of the feedback hypothesis between economic growth and renewable energy consumption in Central and Eastern European countries.
Inventory Routing Analysis for Maritime LNG Supply of German Ports
Authors: Prause Felix , Prause Gunnar 
Published: March 2021

Abstract
After the implementation of Emission Control Areas (ECA) in Northern Europe in 2015, ship operators have to decide for new compliance methods. Among different abatement technologies, also the use of LNG as maritime fuel is one option. Hence, the number of LNG-fueled vessels plying in North Sea and Baltic Sea is growing, so ports have to cope with the increasing demand for LNG. Until now, German ports have been a little bit delayed in the installation of LNG infrastructure. Currently, a new LNG-terminal at Brunsbüttel, the western entrance to the Kiel Canal, is under construction.
The distribution of LNG from the new LNG-hub to the other German ports can be modelled as an Inventory Routing Problem (IRP) that is usually solved by combinatorial optimization methods. This paper investigates the research question, how the distribution can be modeled as an IRP, which distribution mode is the most economic for the German ports and which modal mix for the LNG supply leads to the greenest distribution. The results of this paper are empirically validated by data that were collected in several EU-projects on sustainable supply chain management and green logistics.