bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palliative Radiotherapy Within the Veterans Health Administration: Barriers to Referral and Timeliness of Treatment
Authors: Gutt Ruchika , Malhotra Sheetal , Hagan Michael P. , Lee Steve P. , Faricy-Anderson Katherine , Kelly Maria D. , Hoffman-Hogg Lori , Solanki Abhishek A. , Shapiro Ronald H. , Fosmire Helen , Moses Edwinette , Dawson George A. 
Published: March 2021

PURPOSE:Most Veterans Health Administration hospitals do not have radiation oncology (RO) departments on-site. The purpose of this study is to determine the impact of on-site RO on referral patterns and timeliness of palliative radiation therapy (PRT).MATERIALS AND METHODS:A survey was sent to medical directors at 149 Veterans Health Administration centers. Questions evaluated frequency of referral for PRT, timeliness of RO consults and treatment, and barriers to referral for PRT. Chi-square analysis was used to evaluate differences between centers that have on-site RO and centers that refer to outside facilities.RESULTS:Of 108 respondents, 33 (31%) have on-site RO. Chi-square analysis revealed that RO consult within 1 week is more likely at centers with on-site RO (68% v 31%; P = .01). Centers with on-site RO more frequently deliver PRT for spinal cord compression within 24 hours (94% v 70%; P = .01). Those without on-site RO were more likely to want increased radiation oncologist involvement (64% v 26%; P < .001). Barriers to referral for PRT included patient ability to travel (81%), patient noncompliance (31%), delays in consult and/or treatment (31%), difficulty contacting a radiation oncologist (14%), and concern regarding excessive number of treatments (13%). Respondents with on-site RO less frequently reported delays in consult and/or treatment (6% v 41%; P < .0001) and difficulty contacting a radiation oncologist (0% v 20%; P = .0056) as barriers.CONCLUSION:Respondents with on-site RO reported improved communication with radiation oncologists and more timely consultation and treatment initiation. Methods to improve timeliness of PRT for veterans at centers without on-site RO should be considered.
Reliability of respiratory-triggered two-dimensional cine k-adaptive-t-autocalibrating reconstruction for Cartesian sampling for the assessment of biventricular volume and function in patients with repaired tetralogy of Fallot
Authors: Orii Makoto , Sugawara Tsuyoshi , Takagi Hidenobu , Nakano Satoshi , Ueda Hironobu , Takizawa Yurie , Fujiwara Jumpei , Takahashi Shin , Oyama Kotaro , Lai Peng , Janich Martin A , Nozaki Atsushi , Yoshioka Kunihiro 
Published: March 2021

Objective:
To compare left ventricular (LV) and right ventricular (RV) volume, function, and image quality of a respiratory-triggered two-dimensional (2D)-cine k-adaptive-t-autocalibrating reconstruction for Cartesian sampling (2D kat-ARC) with those of the standard reference, namely, breath-hold 2D balanced steady-state free precession (2D SSFP), in patients with repaired tetralogy of Fallot (TOF).

Methods:
30 patients (14 males, mean age 32.2 ± 13.9 years) underwent cardiac magnetic resonance, and 2D kat-ARC and 2D SSFP images were acquired on short-axis view. Biventricular end-diastolic volume (EDV) and end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and LV mass (LVM) were analysed.

Results:
The 2D kat-ARC had significantly shorter scan time (35.2 ± 9.1 s vs 80.4 ± 16.7 s; p &lt; 0.0001). Despite an analysis of image quality showed significant impairment using 2D kat-ARC compared to 2D SSFP cine (p &lt; 0.0001), the two sequences demonstrated no significant difference in terms of biventricular EDV, LVESV, LVSV, LVEF, and LVM. However, the RVESV was overestimated for 2D kat-ARC compared with that for 2D SSFP (73.8 ± 43.2 ml vs 70.3 ± 44.5 ml, p = 0.0002) and the RVSV and RVEF were underestimated (RVSV = 46.2±20.5 ml vs 49.4 ± 20.4 ml, p = 0.0024; RVEF = 40.2±12.7% vs. 43.5±14.0%, p = 0.0002).

Conclusion:
Respiratory-triggered 2D kat-ARC cine is a reliable technique that could be used in the evaluation of LV volumes and function.

Advances in knowledge:
2D cine kat-ARC is a reliable technique for the assessment LV volume and function in patients with repaired TOF.
Prosthodontic Pathways in the Interdisciplinary Management of a Patient with an Ameloblastoma in the Maxilla
Authors: Susiripala Y.K.Shashie Nathaliya , Sivaguru Vasantha 
Published: March 2021

Ameloblastoma is a benign and locally aggressive neoplasm. The treatment of choice is surgical resection, which, although removing tumour, will often result in aesthetic and functional problems for the patient. CPD/Clinical Relevance: For patients with ameloblastoma in the maxilla, careful planning with the involvement of a multidisciplinary team is essential for improving post-surgical quality of life.
A Review of the Evidence for the Provision of the Routine Scale and Polish for the Prevention of Periodontal Disease
Authors: Birt Rachel , Healy Claire M , MacCarthy Denise , Winning Lewis 
Published: March 2021

The routine scale and polish is the most commonly performed treatment procedure in general dental practice. With a large proportion of state dental health expenditure in the UK and Ireland being used to provide ‘routine scale and polish’ treatments, it is necessary to establish the true value of this treatment for patients. In this narrative review, we discuss the available evidence regarding provision of the routine scale and polish. Based on the available studies, there is little evidence to support the use of the routine scale and polish alone for the prevention of periodontal disease. CPD/Clinical Relevance: This paper evaluates the evidence surrounding the routine provision of scaling and polishing for the prevention of gingivitis and periodontitis.
Effective use of Translation Services in Dentistry
Authors: Patel Kajal B , Walshaw Emma G , Adam Naeem I 
Published: March 2021

Translation services are central to effective communication with patients unable to speak English, or with hearing impairment. This article gives an overview of the cost of translation services in key secondary care locations and provides guidance on how best to optimize their use clinically. Freedom of information requests were made to 20 dental hospitals in the United Kingdom to ascertain the number and cost of interpreter and sign-language appointments. We highlight the importance of using these necessary but costly services effectively. CPD/Clinical Relevance: Guidance is given on how to best use translator services in a dental setting, better ensuring valid consent and promoting patient autonomy.
Clinical decision-making in older adults following emergency admission to hospital. Derivation and validation of a risk stratification score: OPERA
Authors: Arjan Khushal , Forni Lui G. , Venn Richard M. , Hunt David , Hodgson Luke Eliot 
Published: March 2021

Objectives of the studyDemographic changes alongside medical advances have resulted in older adults accounting for an increasing proportion of emergency hospital admissions. Current measures of illness severity, limited to physiological parameters, have shortcomings in this cohort, partly due to patient complexity. This study aimed to derive and validate a risk score for acutely unwell older adults which may enhance risk stratification and support clinical decision-making.MethodsData was collected from emergency admissions in patients ≥65 years from two UK general hospitals (April 2017- April 2018). Variables underwent regression analysis for in-hospital mortality and independent predictors were used to create a risk score. Performance was assessed on external validation. Secondary outcomes included seven-day mortality and extended hospital stay.ResultsDerivation (n = 8,974) and validation (n = 8,391) cohorts were analysed. The model included the National Early Warning Score 2 (NEWS2), clinical frailty scale (CFS), acute kidney injury, age, sex, and Malnutrition Universal Screening Tool. For mortality, area under the curve for the model was 0.79 (95% CI 0.78–0.80), superior to NEWS2 0.65 (0.62–0.67) and CFS 0.76 (0.74–0.77) (P<0.0001). Risk groups predicted prolonged hospital stay: the highest risk group had an odds ratio of 9.7 (5.8–16.1) to stay >30 days.ConclusionsOur simple validated model (Older Persons’ Emergency Risk Assessment [OPERA] score) predicts in-hospital mortality and prolonged length of stay and could be easily integrated into electronic hospital systems, enabling automatic digital generation of risk stratification within hours of admission. Future studies may validate the OPERA score in external populations and consider an impact analysis.
Sub-lethal aquatic doses of pyriproxyfen may increase pyrethroid resistance in malaria mosquitoes
Authors: Opiyo Mercy A. , Ngowo Halfan S. , Mapua Salum A. , Mpingwa Monica , Nchimbi Nuru , Matowo Nancy S. , Majambere Silas , Okumu Fredros O. 
Published: March 2021

Background
Pyriproxyfen (PPF), an insect growth hormone mimic is widely used as a larvicide and in some second-generation bed nets, where it is combined with pyrethroids to improve impact. It has also been evaluated as a candidate for auto-dissemination by adult mosquitoes to control Aedes and Anopheles species. We examined whether PPF added to larval habitats of pyrethroid-resistant malaria vectors can modulate levels of resistance among emergent adult mosquitoes.

Methodology
Third-instar larvae of pyrethroid-resistant Anopheles arabiensis (both laboratory-reared and field-collected) were reared in different PPF concentrations, between 1×10−9 milligrams active ingredient per litre of water (mgAI/L) and 1×10−4 mgAI/L, or no PPF at all. Emergent adults escaping these sub-lethal exposures were tested using WHO-standard susceptibility assays on pyrethroids (0.75% permethrin and 0.05% deltamethrin), carbamates (0.1% bendiocarb) and organochlorides (4% DDT). Biochemical basis of pyrethroid resistance was investigated by pre-exposure to 4% PBO. Bio-efficacies of long-lasting insecticide-treated nets, Olyset® and PermaNet 2.0 were also examined against adult mosquitoes with or without previous aquatic exposure to PPF.

Results
Addition of sub-lethal doses of PPF to larval habitats of pyrethroid-resistant An. arabiensis, consistently resulted in significantly reduced mortalities of emergent adults when exposed to pyrethroids, but not to bendiocarb or DDT. Mortality rates after exposure to Olyset® nets, but not PermaNet 2.0 were also reduced following aquatic exposures to PPF. Pre-exposure to PBO followed by permethrin or deltamethrin resulted in significant increases in mortality, compared to either insecticide alone.

Conclusions
Partially-resistant mosquitoes exposed to sub-lethal aquatic concentrations of PPF may become more resistant to pyrethroids than they already are without such pre-exposures. Studies should be conducted to examine whether field applications of PPF, either by larviciding or other means actually exacerbates pyrethroid-resistance in areas where signs of such resistance already exist in wild the vector populations. The studies should also investigate mechanisms underlying such magnification of resistance, and how this may impact the potential of PPF-based interventions in areas with pyrethroid resistance.
Healthcare providers experiences of using uterine balloon tamponade (UBT) devices for the treatment of post-partum haemorrhage: A meta-synthesis of qualitative studies
Authors: Finlayson Kenneth , Vogel Joshua P. , Althabe Fernando , Widmer Mariana , Oladapo Olufemi T. 
Published: March 2021

BackgroundPostpartum haemorrhage (PPH) is a leading cause of maternal mortality and severe morbidity globally. When PPH cannot be controlled using standard medical treatments, uterine balloon tamponade (UBT) may be used to arrest bleeding. While UBT is used by healthcare providers in hospital settings internationally, their views and experiences have not been systematically explored. The aim of this review is to identify, appraise and synthesize available evidence about the views and experiences of healthcare providers using UBT to treat PPH.MethodsUsing a pre-determined search strategy, we searched MEDLINE, CINAHL, PsycINFO, EMBASE, LILACS, AJOL, and reference lists of eligible studies published 1996–2019, reporting qualitative data on the views and experiences of health professionals using UBT to treat PPH. Author findings were extracted and synthesised using techniques derived from thematic synthesis and confidence in the findings was assessed using GRADE-CERQual.ResultsOut of 89 studies we identified 5 that met our inclusion criteria. The studies were conducted in five low- and middle-income countries (LMICs) in Africa and reported on the use of simple UBT devices for the treatment of PPH. A variety of cadres (including midwives, medical officers and clinical officers) had experience with using UBTs and found them to be effective, convenient, easy to assemble and relatively inexpensive. Providers also suggested regular, hands-on training was necessary to maintain skills and highlighted the importance of community engagement in successful implementation.ConclusionsProviders felt that administration of a simple UBT device offered a practical and cost-effective approach to the treatment of uncontrolled PPH, especially in contexts where uterotonics were ineffective or unavailable or where access to surgery was not possible. The findings are limited by the relatively small number of studies contributing to the review and further research in other contexts is required to address wider acceptability and feasibility issues.
Perfil, qualidade de vida e uso de medicamentos em pacientes renais crônicos submetidos à hemodiálise
Authors: Dutra-Costa Emanuele Gama , Uliana Daniela Bissoli , Souza Pâmela Schettino , Cassiano Valéria Oliveira , Santiago-Silva Juliana 
Published: March 2021

Atualmente vem aumentando o número de pessoas que são diagnosticadas com Doença Renal Crônica (DRC) e que são submetidas à hemodiálise. Sabe-se que a qualidade de vida dessas pessoas vem a influenciar na ocorrência dessa doença, visto que, cada vez mais, hábitos de vida menos saudáveis vem contribuindo para isso. Avaliar o perfil, a qualidade de vida, e o uso de medicamentos em pacientes renais crônicos submetidos a tratamento em uma clínica de hemodiálise localizada na região da zona da Mata Mineira e a atuação do farmacêutico neste contexto. Foi realizada uma pesquisa com 73 pacientes que aceitaram participar voluntariamente da pesquisa, assinando o Termo de Consentimento Livre Esclarecido (TCLE). Como instrumento foi utilizado um questionário com a finalidade de caracterizar e analisar os pacientes quanto à idade, sexo, estado civil, escolaridade, tempo de tratamento de hemodiálise, atividades comprometidas pelo tratamento, uso de medicamentos, entre outros. Entre os pacientes com DRC investigados, houve a prevalência de indivíduos adultos, casados, com baixa escolaridade e aposentados. Entretanto, não foi encontrada diferença significante entre o sexo. A maioria faz hemodiálise há mais de cinco anos e relata interferências do tratamento na vida profissional e pessoal. Verificou-se neste estudo que a maioria dos pacientes participantes da pesquisa realiza a politerapia e por vezes descontinua o tratamento por conta própria. Medidas de acompanhamento multidisciplinares juntamente aos pacientes submetidos à hemodiálise são necessárias, auxiliando na adesão ao tratamento e melhoria da condição de vida destes.
Stellar Object Detection Using the Wavelet Transform
Authors: Anisimova E. , Páta P. , Blažek M. 
Published: March 2021

Several algorithms are used nowadays for detecting stellar objects in astronomical images, for example in the DAOPHOTprogram package and in SExtractor (Software for source extraction). Our team has become acquainted with the wavelet transform and its good localization properties. After studying the manual for DAOPHOT and SExtractor, and becoming familiar with the trous algorithm used for calculating the wavelet transform, we set ourselves the task to implement an algorithm for star detection on the basis of the wavelet transform. We focused on detecting stellar objects in complex fields, such as globular clusters and galaxies. This paper describes a stellar object detection algorithm with the help ofthe wavelet transform, and presents our results.
Computational model of decreased suppression of mu rhythms in patients with Autism Spectrum Disorders during movement observation—preliminary findings
Authors: Zapała Dariusz , Mikołajewski Dariusz 
Published: March 2021

AbstractObjectivesAutism Spectrum Disorders (ASD) represent developmental conditions with deficits in the cognitive, motor, communication and social domains. It is thought that imitative behaviour may be impaired in children with ASD. The Mirror Neural System (MNS) concept plays an important role in theories explaining the link between action perception, imitation and social decision-making in ASD.MethodsIn this study, Emergent 7.0.1 software was used to build a computational model of the phenomenon of MNS influence on motion imitation. Seven point populations of Hodgkin–Huxley artificial neurons were used to create a simplified model.ResultsThe model shows pathologically altered processing in the neural network, which may reflect processes observed in ASD due to reduced stimulus attenuation. The model is considered preliminary—further research should test for a minimally significant difference between the states: normal processing and pathological processing.ConclusionsThe study shows that even a simple computational model can provide insight into the mechanisms underlying the phenomena observed in experimental studies, including in children with ASD.
Crystal structure of (R)-6-(benzo[b]thiophen-5-yl)-2-methyl-2,6-dihydrobenzo [5,6] silino[4,3,2-cd]indole, C23H17NSSi
Authors: Kong Yuan-Fang , Mu De-Long 
Published: March 2021

Abstract
C23H17NSSi, orthorhombic, P212121 (no. 19), a = 7.7862(5) Å, b = 9.0728(6) Å, c = 25.3797(16) Å, V = 1792.9(2) Å3, Z = 4, R

gt
(F) = 0.0301, wR

ref
(F
2) = 0.0778, T = 100.0 K.
Nanoscale imaging of the functional anatomy of the brain
Authors: Arizono Misa , Bancelin Stéphane , Bethge Philipp , Chéreau Ronan , Idziak Agata , Inavalli V.V.G. Krishna , Pfeiffer Thomas , Tønnesen Jan , Nägerl U. Valentin 
Published: March 2021

Abstract
Progress in microscopy technology has a long history of triggering major advances in neuroscience. Super-resolution microscopy (SRM), famous for shattering the diffraction barrier of light microscopy, is no exception. SRM gives access to anatomical designs and dynamics of nanostructures, which are impossible to resolve using conventional light microscopy, from the elaborate anatomy of neurons and glial cells, to the organelles and molecules inside of them. In this review, we will mainly focus on a particular SRM technique (STED microscopy), and explain a series of technical developments we have made over the years to make it practical and viable in the field of neuroscience. We will also highlight several neurobiological findings on the dynamic structure-function relationship of neurons and glia cells, which illustrate the value of live-cell STED microscopy, especially when combined with other modern approaches to investigate the nanoscale behavior of brain cells.
Wilhelm Diltheys Hermeneutik der Religion
Authors: Plaul Constantin 
Published: March 2021

Zusammenfassung
In der Philosophie hat das Interesse an Wilhelm Dilthey in jüngster Zeit wieder merklich zugenommen. Man könnte geradezu von einer kleinen Dilthey-Renaissance sprechen. In der Theologie indes beginnt man sich erst langsam wieder auf sein Werk zu besinnen. Dabei hält es auch für sie wichtige Einsichten bereit. Dilthey ist vor allem deshalb interessant, weil es ihm gelingt, die Religionsthematik konsequent auf dem Boden eines interpretativen Kulturmodells zu entwickeln.
Let Israel’s Pride Fill the Cosmos: A Reformation Correction of Christian Suspicion of Jewish Particularity
Authors: Hopman Nicholas 
Published: March 2021

Summary
This essay is an attempt to exorcise Christian supersessionism. It argues that finding a positive Christian assessment of Jews has been so difficult that the difficulty indicates a basic flaw in the presuppositions behind recent scholarship. Supersessionism has crept into Pauline scholarship, which claims to have overcome old systematic theological concepts, rather blatantly in the New Perspective on Paul and mildly in even the otherwise excellent work of John Barclay. Recent systematic attempts to evaluate Jewishness positively, while technically not supersessionist, overcome Christian supersessionism at the expense of telling Jews how to be Jews. Furthermore, post-supersessionary systematic theology shares many of supersessionism’s presuppositions, including its suspicion of particularity and ethnicity in favor of universalizing concepts. This essay argues that a return to the much-maligned law-gospel distinction of the Reformation offers a path to celebrating Israel’s ethnicity, particularity, and exclusive election by God. Pauline scholarship and post-supersessionary systematic theology both assume that the Torah alone is exclusively for Jews, while the good news of Jesus is inclusive and universal. In contrast this essay argues that the gospel also belongs particularly to the Jews. Though it also blesses particular gentiles, they will remain eternally blessed foreigners.
On how Chalcedonian Christology can be affirmed without the errors of Eutychianism and Nestorianism: A reply to Joshua Farris
Authors: Ter Ern Loke Andrew 
Published: March 2021

Summary
In a recent article published in NZSTh, Joshua Farris follows up on the previous discussion between James Arcadi and myself concerning the abstractist/concretist Christological distinction. While affirming the significance of my Divine Preconscious Model (DPM) of the Incarnation, he argues that I either misunderstand the abstractist/concretist distinction or have a novel take on it, and that I seem to confuse the metaphysical abstract/concretist distinction with a semantic distinction. His constructive proposal is that I should take up an abstractist Christology. I respond to his criticisms and show that his proposal fails to note one of the most important contributions of DPM, viz. it demonstrates how Chalcedonian Christology can be affirmed without the error of Eutychianism on the one hand and Nestorianism on the other.