bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Politik Hukum Pengaruh Oligarki dan Budaya Korupsi di Kabupaten Bangkalan
Authors: Sami an Sami an , Prakasa Satria Unggul Wicaksana 
Published: November 2021

Penelititian ini bertujuan mendiskripsikan penyalahgunaan kekuasaan oleh kaum blater di daerah otonomi bangkalan dimana dalam penelitian ini menganalisis tentang jaringan politk oligarki di bangkalan beserta sebab dan akibat hukum yang timbul dari praktek oligark tersebut. Jenis penelitian ini adalah penelitian Social-Legal.sedangkan sumber data dalam penelitian ini adalah studi kasus KH Fuad Amin . menginterpretasi data secara deskriptif menggunakan pendekatan sosiologi legal.Hasil penelitian menunjukkan bahwa terdapat bentuk-bentuk penyalahgunaan kekuasaan dalam terhadap jabatan di daerah bangkalan yaitu: (1)politik oligarki ; (2) pelanggaran Ham; (3) korupsi; (4) hegemoni kelas sosial;. Rumusan Berdasarkan Fakta yang dibahas selama penelitian ini adalah 1.Pertanggung jawaban hukum Oligarki dikalangan pebisnis,pemerintah dan aparat di kabupaten bangkalan 2.Analisis politik hokum dan budaya hukum menguatnya oligarki di Kabupaten Bangkalan.Simpulan penelitian ini adalah mengembalikan peran pemerintahan daerah dibangkalan berdasarkan UU No.23 tahun 2014 tentang pemerintah daerah serta menghilangkan hegemoni kelas sosial dalam politik hukum dan budaya hukum terhadap sistem demokrasi di pemerintahan kabupaten bangkalan
Caracterización bioquímica del síndrome nefrótico de una población pediátrica en Villahermosa, Tabasco. / Biochemical characterization of the nephrotic syndrome of a pediatric population in Villahermosa, Tabasco.
Authors: Salomón-Cruz Josefina 
Published: November 2021

ResumenEl síndrome nefrótico se diagnóstica con base en cuatro criterios: proteinuria, hipoalbuminemia, edema e hipercolesterolemia. Generalmente se presenta entre los 2 y 10 años de edad. Este trabajo se realizó para determinar la caracterización bioquímica del síndrome nefrótico de la población infantil del Hospital del Niño de Villahermosa, Tabasco, México.Estudio descriptivo, transversal, retrospectivo realizado en el laboratorio clínico del Hospital del Niño Dr. Rodolfo Nieto Padrón de enero 2016 a diciembre 2017. Se obtuvo el rango y promedio de las pruebas bioquímicas de pacientes con síndrome nefrótico.Se analizaron 33 pacientes referidos con diagnóstico de síndrome nefrótico, encontrándose una media de albumina de 1.3g/dl, colesterol de 482.6 mg/dl y triglicéridos de 523.2 mg/d y una proteinuria media de 295.9 mg/dll. Palabras clave: Síndrome nefrótico, Hipoalbuminemia, Hipercolesterolemia. AbstractThe nephrotic syndrome is diagnosed based on four criteria: proteinuria, hypoalbuminemia, edema and hypercholesterolemia. It usually occurs between 2 and 10 years of age. This work was carried out to determine the biochemical characterization of the nephrotic syndrome of the infant population of the Hospital del Niño de Villahermosa, Tabasco, Mexico.Methodology:. Descriptive, cross-sectional, retrospective study conducted in the clinical laboratory of the Dr. Rodolfo Nieto Padrón Children's Hospital from January 2016 to December 2017. The range and average of the biochemical tests of patients with nephrotic syndrome was obtained.Results Thirty-three referred patients with a diagnosis of nephrotic syndrome were analyzed, finding a mean albumin of 1.3 g / dl, cholesterol of 482.6 mg / dl and triglycerides of 523.2 mg / d and an average proteinuria of 295.9 mg / dL. Key words: Nephrotic syndrome, Hypoalbuminemia, Hypercholesterolemia.
Model for comprehensive management of patients and family members with noncommunicable diseases.
Authors: Domínguez-Isidro Tania Ivette , Guzmán-Priego Crystell Guadalupe , Cordova Hernández Juan Antonio , Del Valle-Laveaga David , Muñoz Cano Juan Manuel 
Published: November 2021

Introduction. Non-communicable diseases associated with diet are preventable and manageable with comprehensive pharmacological and non-pharmacological treatment. However, in Tabasco, as in Mexico, and many countries, these diseases increase in prevalence, as well as the severity of their complications and increase the lability of patients to others such as covid-19, in a syndemic. This is why projects are needed to promote this comprehensive care. Methods. It is a descriptive, cross-sectional investigation for the elaboration of the strategic planning of a High Specialty Hospital oriented to non-communicable diseases. A diagnosis was made in a first stage from which a proposal was elaborated. Results. The diagnosis showed that medical graduates need to learn how to be leaders to accompany their patients to the achievement of treatment goals. A comprehensive care project was designed. It consists of services for the acceptance of the disease, education for a healthy lifestyle, learning for the selection of dishes and products for sustainability, supported by a collection of videos and podcasts prepared for this project, as well as follow-up to keep the patients and their families in the service. Indicators were developed according to results. Conclusions. The construction of a comprehensive management of patients to reduce progression, the number of patients and prevent secondary and tertiary organic damage, is a priority for the reconfiguration of services.

Keywords. Progression; Prevention; Healthy life style; Social marketing; Leadership
Analyzing the Impacts of Meshing and Grid Alignment in Dual-Porosity Dual-Permeability Upscaling
Authors: Xu Ziming , Leung Juliana Y. 
Published: November 2021

SummaryThe discrete fracture network (DFN) model is widely used to simulate and represent the complex fractures occurring over multiple length scales. However, computational constraints often necessitate that these DFN models be upscaled into a dual-porosity dual-permeability (DPDK) model and discretized over a corner-point grid system, which is still commonly implemented in many commercial simulation packages. Many analytical upscaling techniques are applicable, provided that the fracture density is high, but this condition generally does not hold in most unconventional reservoir settings. A particular undesirable outcome is that connectivity between neighboring fracture cells could be erroneously removed if the fracture plane connecting the two cells is not aligned along the meshing direction.In this work, we propose a novel scheme to detect such misalignments and to adjust the DPDK fracture parameters locally, such that the proper fracture connectivity can be restored. A search subroutine is implemented to identify any diagonally adjacent cells of which the connectivity has been erroneously removed during the upscaling step. A correction scheme is implemented to facilitate a local adjustment to the shape factors in the vicinity of these two cells while ensuring the local fracture intensity remains unaffected. The results are assessed in terms of the stimulated reservoir volume calculations, and the sensitivity to fracture intensity is analyzed.The method is tested on a set of tight oil models constructed based on the Bakken Formation. Simulation results of the corrected, upscaled models are closer to those of DFN simulations. There is a noticeable improvement in the production after restoring the connectivity between those previously disconnected cells. The difference is most significant in cases with medium DFN density, where more fracture cells become disconnected after upscaling (this is also when most analytical upscaling techniques are no longer valid); in some 2D cases, up to a 22% difference in cumulative production is recorded. Ignoring the impacts of mesh discretization could result in an unintended reduction in the simulated fracture connectivity and a considerable underestimation of the cumulative production.
A Novel Smart Textiles To Reflect Emotion
Authors: DAI JINGYU , DUAN LING , DAI HONGYU , XIE YUTONG 
Published: November 2021

Abstract
The present study designs a wearable smart device regarding relationship between temperature and emotion. The device, amplifies, and sub-regionally transmits the current generated by the body temperature thermoelectric generator through a smart body temperature sensor. Different areas of clothing produce controllable and intelligent color, so that adult emotions can be understood through changes in clothing colors, which is conducive to judging their moods and promoting social interaction. Experimental results show that the device can accurately detect changes in human body temperature under hilarious, fearful, soothing, and angry emotions, so as to achieve changes in clothing colors, namely blue, red, green, and brown.
Sublethal Effects of The Toxic Alga Karlodinium Veneficum On Fish
Authors: Llanos-Rivera Alejandra , Álvarez-Muñoz Katia , Astuya-Villalón Allisson , López-Rosales Lorezo , García-Camacho Francisco , Sánchez-Mirón Asterio , Krock Bernd , Rodriguez Juan Jose Gallardo 
Published: November 2021

Abstract
Dinoflagellates of the genus Karlodinium are ichthyotoxic species that produce karlotoxins. Karlotoxins show hemolytic and cytotoxic activities and have been associated with fish mortality. This study evaluated the effect of toxins released into the environment of Karlodinium veneficum strain K10 (Ebro Delta, NW Mediterranean) on the early stages of Danio rerio (zebrafish). Extracts of supernatant of K10 contained KmTx-10, -11, -12, -13, and a sulfated form of KmTx-10. Total egg mortality was observed for karlotoxins concentration higher than 2.69 µg L−1 and the 1.35 µg L−1, 87% of development anomalies were evidenced (concentrations expressed as KmTx-2 equivalent). Larvae of 8 days post-fertilization exposed to 1.35 µg L−1 presented epithelial damage with 80% of cells in the early apoptotic stage. Our results indicate that supernatants with low concentration of KmTxs produce both lethal and sublethal effects in early fish stages. Moreover, apoptosis was induced at concentrations as low as 0.01 µg L−1. This is of great relevance since detrimental long-term effects due to exposure to low concentrations of these substances could affect wild and cultured fish.
METTL1 Mediated m7G Modification Regulates Ferroptosis and Chemotherapy Resistance via Involvement of pri-miR-26a/FTH1 Axis in Osteosarcoma
Authors: Yuan Ye , He Mingyu , Wang Yang , Pu Jiaying , Shen Zhihua , Wang Tong , Li Guanghui , Mei Zhongting , Wang Ao , Ren Zijing , Liu Ying , Wang Wenbo , Liu Xiaoyan , Lei Hong , He Xiaoqi , Liu Qian , Hong Jinhuan , Du Weijie , Yang Lei 
Published: November 2021

Abstract
Background

N7-Methyladenosine (m7G), one of the most prevalent internal modifications in mammalian RNAs, makes a great contribution to many bioprocesses. However, its functions and underlying mechanisms in the occurrence and development of osteosarcoma remain elusive.
Methods

The expression of METTL1 and its correlation with clinicopathological features using tissue microarrays and the Cancer Genome Atlas (TCGA) dataset.Targets of METTL1 on osteosarcoma were identified by AlkAniline-seq, RNA immunoprecipitation (RIP), quantitative real-time PCR, western blot and luciferase assays. The effects of METTL1 on the biological characteristics of osteosarcoma cells were investigated on the basis of gain- and loss-of-function analyses. Ferroptosis were analyzed by lipid peroxidation assay, iron assay and ransmission electron microscopy (TEM). Subcutaneous models further uncovered the role of METTL1 in tumour growth.
Results

Here, we have identified that METTL1, an m7G methyltransferase, is low expressed in osteosarcoma tissues and plays an antitumor role in osteosarcoma. Mechanistically, METTL1 enhances cell ferroptosis by targeting pri-miR-26a and promoting its mature through m7G methylation, which could target FTH1 mRNA and eliminate FTH1 translation efficiency mediated by METTL1. FTH1 is the main component of ferritin which is crucial for iron homeostasis and the inhibition of lipid peroxidation. Reduction of FTH1 translation dramatically increases ferroptosis and enhances osteosarcoma chemosensitivity.
Conclusions

Collectively, our study demonstrates the METTL1/pri-miR-26a/FTH1 axis signaling in osteosarcoma and highlights the functional importance of METTL1 and m7G methylation in the progression and chemotherapy resistance of osteosarcoma, suggesting that reprogramming RNA m7G methylation as a potential and promising strategy for osteosarcoma treatment.
Screening and Identification of The Key LncRNAs Associated With Fat Deposition in Ovine Tail
Authors: Su Xiaohui , He Haiying , Fang Chao , Liu Lingling , Liu Wujun 
Published: November 2021

Abstract
Background: Sheep is an important meat-producing animal, and low tail fat deposition level has become one of the main targets of meat production. LncRNAs have recently received special attention due to their critical role in many important biological processes. There are few reports on its regulatory function in ovine fat deposition. In this study, two sheep populations with different tail types in Xinjiang, Bashby sheep (fat-tailed) and the hybrid population of Bashby sheep and wild argali (small-tailed), were selected for whole transcriptome resequencing from their tail tissues. Results: First, 728 differentially expressed lncRNA (DElncRNAs) of tail fat between Bashby and F2 sheep were identified by RNA-seq. Second, the tissue expression profile and relative expression difference between Bashby and F2 sheep of 7 of 728 DE lncRNAs were analyzed by RT-PCR. We conclude that MSTRG.37980, MSTRG.38164, MSTRG.36912 and MSTRG.36913 positively regulate fat deposition, while MSTRG.8169, MSTRG.24995 and MSTRG.31389 inhibit fat deposition. Third, GO and KEGG analysis revealed that lncRNA targets were mainly participated in energy metabolism, growth and development and immunity, such as viral carcinogenesis, Chemokine signaling pathway, B cell receptor signaling pathway. And the expression pattern of target genes in each tissue was similar to that of the corresponding lncRNAs, which required us to conduct further research on target genes. Conclusions: This study was the first to systematically identify fat deposition-associated lncRNAs in ovine tail fat and construct DElncRNAs profiles. Our findings will help understand the molecular mechanism of fat deposition from transcriptomic perspectives.
Prognostic Value and Biological Function of LRRN4 in Colorectal Cancer
Authors: Xu Cheng , Chen Yulin , Long Feiwu , Ye Junman , Li Xue , Huang Qiaorong , Yao Dejiao , Wang Xiaoli , Zhao Jin , Meng Wentong , Mo Xianming , Lu Ran , Fan Chuanwen , Zhang Tao 
Published: November 2021

Abstract
Background: Several nervous and nerve-related biomarkers have been detected in colorectal cancer (CRC) and can contribute to the progression of CRC. However, the role of leucine-rich repeat neuronal 4 (LRRN4), a recently identified neurogenic marker, in CRC remains unclear. Methods: We examined the expression and the clinical outcomes of LRRN4 in CRC from TCGA-COREAD mRNA-sequencing datasets and immunohistochemistry on the Chinese cohort. Furthermore, the colony formation, flow cytometry, wound healing assay and mouse xenograft models were used to investigate the biological significance of LRRN4 in CRC cell lines with LRRN4 knockdown or overexpression in vitro and in vivo. In addition, weighted co-expression network analysis and DAVID were used to explore the potential molecular mechanism. Results: We provide the first evidence that LRRN4 expression, at both the protein and mRNA level, was remarkable high in CRC compared to controls and positively correlated with the clinical outcome of CRC patients. Specifically, LRRN4 was an independent prognostic factor for progression-free survival and overall survival in CRC patients. Further functional experiments showed that LRRN4 promoted cell proliferation, cell DNA synthesis and cell migration and inhibited apoptosis. Knockdown of LRRN4 can correspondingly decrease these effects in vitro and can significantly suppress the growth of xenografts. Several biological functions and signaling pathways were regulated by LRRN4, including proteoglycans in cancer, glutamatergic synapse, Ras, MAPK and PI3K.Conclusions: Our results suggest that LRRN4 could be a biological and molecular determinant to stratify CRC patients into distinct risk categories, and mechanistically, this is likely attributable to LRRN4 in regulating several malignant phenotypes of neoplastic cells via cancer-related pathways.
The Effect of Stress, Worries and Resilience on Sleep Quality of Chinese Population During the Normalization of COVID-19 Pandemic Prevention and Control
Authors: Ma Hongfei , Liu Minghui , Zhao Shuang , Long Meijun , Diao Yucong , Feng Ziyi , Wu Hui , Wang Yang 
Published: November 2021

Abstract
Background: The COVID-19 pandemic has spread worldwide and has attracted considerable attention. This study aims to investigate the sleep quality of the public during the normalization of COVID-19 pandemic prevention and control in China, as well as related factors that affect sleep quality. Methods: A web-based cross-sectional survey was implemented from Feb 2nd to Feb 9th, 2021 in China. A total of 613 subjects from 27 provinces and 4 municipalities participated in this study. Questionnaire including Pittsburgh Sleep Quality Index (PSQI), COVID Stress Scale (CSS), COVID-19 Worry Scale and 14-item Resilience Scale (the RS-14) as well as demographic characteristics and pandemic-related information was used to measure sleep quality, stress, worries and resilience of Chinese population. Hierarchical multiple regression analysis was conducted to explore the associated factors of sleep quality.Results: The prevalence of poor sleep quality among 613 participants was 41.1% (95%CI=37.2%-45%). Regression analysis indicated that chronic diseases, medical visits, occupation, and negative life events were factors affecting sleep quality. Stress and worries were positively associated with score of sleep quality, while resilience was negatively associated with score of sleep quality. Conclusions: During the normalization of COVID-19 pandemic prevention and control, Chinese public has poor sleep quality. Effective interventions should be taken to decrease people’s COVID-19 stress and worries. Resilience enhancement is also an important factor to be considered to improve people’s sleep quality.
COVID-Inconfidentes: How did COVID-19 and home office influence the prevalence of leisure-time physical inactivity? An analysis of before and during the pandemic
Authors: de Moura¹ ² Samara Silva , Menezes-Júnior¹ ² Luiz Antônio Alves , Rocha² Ana Maria Sampaio , Lourenção² Luciano Garcia , Carraro¹ Júlia Cristina Cardoso , Machado-Coelho¹ ² George Luiz Lins , Meireles² Adriana Lúcia 
Published: November 2021

Abstract
Background

The COVID-19 pandemic has brought drastic changes to the lives of the global population. The restrictions imposed by government agencies impacted the daily lives of citizens, influencing several health behaviors, such as physical activity (PA). Thus, the present study aimed to assess the prevalence of physical inactivity (PI) and its associated factors before and during the COVID-19 pandemic.
Methods

A population-based household seroepidemiological survey was conducted in two Brazilian municipalities located in the state of Minas Gerais, in which 1750 volunteers were interviewed between October and December 2020. Face-to-face interviews were conducted using a structured questionnaire in an electronic format. The moments considered for the PI analysis were M0 (before the pandemic), M1 (from March to July 2020), and M2 (from October to December 2020). Descriptive statistics and univariate and multivariate logistic regression were used to examine the factors associated with PI before (M0) and during the pandemic (M1 and M2).
Results

The prevalence of PI was higher in the first months of the pandemic (M1) (67.3%; 95% confidence interval (CI): 62.4-71.9) than in the months from October to December 2020 (M2) (58.7%; 95% CI: 52.8-64.3); however, at both times (M1 and M2), PI was more prevalent than in the period before the pandemic started (M0) (39.7%; 95% CI: 35.6-43.8). Individuals who were overweight, obese, and had low educational levels were more likely to be physically inactive. At both M1 and M2, individuals who worked at a home office were less likely to have PI.
Conclusions

The results suggest that the COVID-19 pandemic negatively influenced PA, substantially increasing the prevalence of PI. The determinants associated with PI were education, body mass index, and home office work.
miRNA-485-5p, an Inflammation-Related microRNA, May be a Diagnostic Biomarker of Rheumatoid Arthritis
Authors: Jiang Dan , Zheng Ximing , Chen Jian , Zhang Aijun , Xu Guangxian 
Published: November 2021

Abstract
Background

Rheumatoid arthritis (RA) is a chronic systematic autoimmune disorder that is characterized by symmetrical and inflammatory destruction of distal joints. Dysregulation of microRNAs(miRNAs) are frequently involved in inflammation, and can contribute to pathogenesis and progression of RA. This study aimed to investigate the expression of multiple inflammation-related miRNAs of RA patients and the latent mechanism, and identify novel diagnostic biomarkers.
Methods

Samples of 100 patients with RA and 72 healthy controls were included. The expression of predicted inflammation-related miRNAs, including miR-16, miR-17, miR-132, miR-140, miR-150, miR-181, miR-200-c, miR-203, miR-223 and miR-485-5p and RA associated genes, including IL-17, IL-18, DAS-28, MMP3, TLR-4, IRAK-4 in plasma and peripheral blood mononuclear cells (PBMCs) of RA patients compared with healthy controls (HC), were detected by qRT-PCR and ELISA. The interaction between miR-485-5p and TLR-4 or IRAK-4 was verified through dual luciferase report assays, western-blot and correlation analysis. The potential of miR-485-5p to be a biomarker for RA diagnostics was valued by ROC curves.
Results

Among the differentially expressed miRNAs, the expression of miR-485-5p exhibited significantly lower in plasma and PBMCs of the RA patients and was well relevant in the various body fluid samples. The expression of miR-485-5p was negatively correlated with the expression of DAS-28, IL-17, IL-18 and MMP-3, which are significant features of RA. Moreover, the ROC curve of plasma and PBMC miR-485-5p for RA revealed a high diagnostic accuracy. Furthermore, miR-485-5p could inhibit the expression of inflammatory cytokines in macrophages by targeting TLR4 and IRAK4, and the expression of miR-485-5p negatively correlated with the level of TLR4 and IRAK4 in the plasma of RA.
Conclusion

Collectively, our results indicated that down-expression of miR-485-5p was remarkably related to the deterioration of RA progression via the impact on inflammatory cytokines in macrophages, and may serve as a potential diagnostic biomarker and therapeutic target for RA.