bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence as a general-purpose technology: an historical perspective
Authors: Crafts Nicholas 
Published: May 2021

AbstractThis paper looks at the impact on productivity of general-purpose technologies such as steam, electricity, and ICT. It finds they had big effects but only with a lag which was substantial in the first two cases. The experience of the First Industrial Revolution is explored and it is found that this is not a template for a general-purpose technology having a major adverse effect on workers’ living standards. The essence of that industrial revolution was not rapid productivity growth in the short run, but the ‘invention of a new method of invention’ which increased technological progress in the long run. Since artificial intelligence is potentially a general-purpose technology that raises the productivity of research and development, it may be the basis for a Fourth Industrial Revolution.
Suzaku observations of Jovian diffuse hard X-ray emission
Authors: Numazawa Masaki , Ezoe Yuichiro , Ohashi Takaya , Ishikawa Kumi , Miyoshi Yoshizumi , Shiota Daikou , Uchiyama Yasunobu , Kimura Tomoki , Branduardi-Raymont Graziella 
Published: May 2021

Abstract
We report on results of systematic analyses of the entire three X-ray data sets of Jupiter taken by Suzaku in 2006, 2012, and 2014. Jovian diffuse hard X-ray emission was discovered by Suzaku in 2006 when the solar activity went toward its minimum. The diffuse emission was spatially consistent with the Jovian inner magnetosphere and was spectrally fitted with a flat power-law function suggesting non-thermal emission. Thus, a scenario in which ultra-relativistic (tens of MeV) electrons in the Jovian inner magnetosphere inverse-Comptonize solar visible photons into X-ray bands has been hypothetically proposed. We focused on the dependence of the Jovian diffuse hard X-ray emission on the solar activity to verify this scenario. The solar activity in 2012 and 2014 was around the maximum of the 24th solar cycle. By combining the imaging and spectral analyses for the three data sets, we successfully separated the contribution of the diffuse emission from the emission of Jupiter’s body (i.e., the aurora and disk emission). The 1–5 keV luminosity of the diffuse emission has been stable and did not vary significantly, and did not simply depend on the solar activity, which is also known to affect the high-energy electron distribution in the Jovian inner magnetosphere scarcely. The luminosity of the body emission both in 0.2–1 and 1–5 keV, in contrast, probably depended on the solar activity and varied by a factor of 2–5. These results strongly supported the inverse-Compton scattering scenario by the ultra-relativistic electrons. In this paper, we estimate spatial and spectral distributions of the inverse-Compton scattering X-rays by Jovian magnetospheric high-energy electrons with reference to the Divine–Garrett model and found a possible agreement in an inner region (≲10 RJ) for the X-ray observations.
Hot molecular core candidates in the Galactic center 50 km s−1 molecular cloud
Authors: Miyawaki Ryosuke , Tsuboi Masato , Uehara Kenta , Miyazaki Atsushi 
Published: May 2021

Abstract
We present results based on ${2{^{\prime \prime}_{.}}5}$-resolution observations using the Atacama Large Millimeter/Submillmeter Array (ALMA) of the Galactic center molecular cloud G−0.02−0.07, or the 50 km s−1 molecular cloud (50 MC), in the SO (NJ = 22–11) line and 86 GHz continuum emission, the combination of which is considered to trace “hot molecular core candidates” (HMCCs) appearing in the early stage of massive-star formation. In the 86 GHz continuum image, we identified nine dust cores in the central part of the 50 MC, in which four famous compact H ii regions are located. No new ultra-compact H ii regions were found. We also identified 28 HMCCs in the 50 MC with the SO line. The overall SO distribution had no clear positional correlation with the identified H ii regions. The HMCCs in the 50 MC showed a variety of association and non-association with dust and Class I CH3OH maser emissions. The variety suggests that they are not in a single evolutionary stage or environment. Nevertheless, the masses of the identified HMCCs were found to be well approximated by a single power law of their radii, MLTE/(M⊙) = 5.44 × 105 [r/(pc)]2.17 at Tex = 50–100 K. The derived HMCC masses were larger than those of the molecular cores with the same radii in the 50 MC, and also than those of the molecular clumps in the Galactic disk. Additional observations are needed to confirm the nature of these HMCCs in the 50 MC.
The sacrament of confession during Covid-19 pandemic
Authors: Macaraan Willard Enrique R 
Published: May 2021

Abstract
The Covid-19 pandemic has drastically changed the way of life where measures and strategies to adapt and adopt have become normative. In a recent correspondence, the author explores the adaptation of the Last Rites within the pandemic. On this note, the paper explores another sacrament that has also adapted and has adopted new ways to deal with a strong restriction against in-person meetups and gatherings. The sacrament of Confession provides a venue for people to seek healing and counseling. While face-to-face and confessional confessions are still disallowed, the Church has found ways to adapt the sacrament within the context of the pandemic.
Is there any predictive value of the ratio of the upper to the lower diameter of the ureter for ureteral stone impaction?
Authors: Abat Deniz , Börekoğlu Ali , Altunkol Adem , Köse Ilgaz Çağatay , Boğa Mehmet Salih 
Published: May 2021

Abstract

Background:
We aimed to determine if the ratio of the upper to the lower diameter of the ureter could have any predictive value for ureteral stone impaction.

Materials and methods:
Patients who had a solitary unilateral ureteric stone, determined by noncontrast computerized tomography, were assessed if they had undergone ureteroscopic lithotripsy. A total of 111 patients, 84 males (76%), and 27 females (24%), were recruited to the study. Demographic data of the patients and preoperative radiological parameters based on noncontrast computerized tomography were recorded. The impaction status was also assessed during the operation.

Results:
Of the 111 patients, ureteral stones in 63 (57%) patients were determined to be impacted, and ureteral stones in 48 (43%) were nonimpacted. Impacted stones were more common in older patients, female patients, and patients with an American Society of Anesthesiologists score of 2.

Conclusions:
Significant relationships were found between the impaction status and transverse stone length, longest stone length, upper diameter of the ureter, ratio (upper diameter of the ureter/lower diameter of the ureter), and anteroposterior diameter of the pelvis. These parameters were higher in patients with impacted stones.
Potential Mechanisms of In-stent Neointimal Atherosclerotic Plaque Formation
Authors: Zhang Dai-Min , Chen Shao-Liang 
Published: May 2021

Abstract:
Percutaneous coronary intervention has become the main revascularization strategy for coronary artery disease. Compared with early percutaneous coronary angioplasty and the extensive clinical application of bare metal stents, drug-eluting stents can significantly reduce the stenosis caused by the elastic retraction of plaque and neoatherosclerosis (NA), but there is still a high incidence of in-stent restenosis (ISR), which restricts the clinical efficacy of stent implantation. In-stent neoatherosclerosis (ISNA), defined as atherosclerotic lesions in the neointima, is one of the main causes of late stent failure. ISNA plays an important role in stent thrombosis and ISR. The rate of target lesion revascularization and in-stent thrombosis is high when NA arises. Therefore, it is of great clinical significance to explore the occurrence of NA and its development mechanism after stent implantation to prevent ISR and improve stent implantation efficacy and associated clinical prognosis. In this article, we systematically reviewed the existing clinical research on ISNA and the role of optical coherence tomography in its evaluation.
CD40L/CD40 Regulates Adipokines and Cytokines by H3K4me3 Modification in Epicardial Adipocytes
Authors: Yuan Ming , Wu Bin , Zhang Liang , Wang Huan , Yang Yongjun 
Published: May 2021

Abstract:
Epicardial adipose tissue (EAT) dysfunction mediates chronic inflammation by regulating inflammation-related adipokines and cytokines, and it further promotes coronary artery disease (CAD) development. CD40L/CD40 is involved in multiple inflammatory pathways that contribute to various pathophysiological processes. However, the function of CD40L/CD40 in the expression and production of adipokines and cytokines in epicardial adipocytes remains unclear. The purpose of the present study was to explore the role and underlying mechanisms of CD40L/CD40 in adipokine and cytokine expression and production. We isolated adipocytes from EAT tissues of CAD and non-CAD patients. We noticed that CD40 was dramatically increased in EAT tissues of CAD patients. Loss-of-function and gain-of-function studies were performed. The results showed that CD40 silencing reduced recombinant CD40 ligand (rCD40L)–induced upregulation of plasminogen activator inhibitor-1, leptin, interleukin-6, and monocyte chemotactic protein-1 messenger RNA levels and secretion. Overexpression of CD40 displayed the opposite results. In addition, rCD40L triggered mixed lineage leukemia protein-1 (MLL1) expression both in messenger RNA and protein levels. CD40 depletion apparently blocked MLL1 expression, whereas gain of function of CD40 resulted in augmentation of MLL1 levels. Interestingly, chromatin immunoprecipitation-quantitative real-time polymerase chain reaction analysis revealed that CD40 elimination dampened histone H3 lysine 4 trimethylation enrichment at plasminogen activator inhibitor-1, leptin, interleukin-6, and monocyte chemotactic protein-1 promoter regions in the presence of rCD40L. The reverse pattern was observed upon ectopic expression of CD40. Most important, MLL1 silencing effectively reversed the promotive effects of CD40 on adipokine and cytokine secretion. Taken together, our findings suggest that CD40L/CD40 regulates adipokine and cytokine expression by H3 lysine 4 trimethylation modification in adipocytes.
Anisotropy of the Radiation Field Following Canine Sn-117m Treatment
Authors: Arno Matthew G. , Simon Jaime , Stevenson Nigel , Donecker John 
Published: May 2021

Abstract
Tin-117m (117mSn) is used to treated dogs with osteoarthritic joints by radiosynoviorthesis. The internal conversion and Auger electrons emitted by the 117mSn provide the therapeutic effect. Sn-117m also emits gamma rays, of which the most significant is 158.6 keV. The external radiation field around a treated dog is of interest to limit the dose to the owners/caretakers of the dog. The dog’s torso attenuates the radiation being emitted toward the opposite side of the dog’s body. This leads to a radiation field that is significantly non-isotropic. This study characterizes the anisotropy of this field to permit maximum dose rate measurements to be used to calculate the dose to individuals in the vicinity of the dog. Measurements were made in nine directions and at two distances, 0.3 and 1.0 m, to characterize common distances and spatial orientations for human-dog interactions. From these measurements, the percent reduction in the average dose rate compared to the maximum dose rate was determined. From a radiation safety perspective, the important factor is the minimum amount of shielding effectiveness or percent reduction that can be expected. A reasonable measure for this value is the fifth percentile of the shielding effectiveness distribution. The fifth percentile shielding effectiveness measures are 27% and 21% at 0.3 and 1.0 m, respectively.
Central sensitization inventory in endometriosis
Authors: Orr Natasha L. , Wahl Kate J. , Lisonek Michelle , Joannou Angela , Noga Heather , Albert Arianne , Bedaiwy Mohamed A. , Williams Christina , Allaire Catherine , Yong Paul J. 
Published: May 2021

Abstract
A key clinical problem is identifying the patient with endometriosis whose pain is complicated by central nervous system sensitization, where conventional gynecologic treatment (eg, hormonal therapy or surgery) may not completely alleviate the pain. The Central Sensitization Inventory (CSI) is a questionnaire previously validated in the chronic pain population. The objective of this study was an exploratory proof-of-concept to identify a CSI cutoff in the endometriosis population to discriminate between individuals with significant central contributors (identified by central sensitivity syndromes [CSS]) to their pain compared to those without. We analyzed a prospective data registry at a tertiary referral center for endometriosis, and included subjects aged 18 to 50 years with endometriosis who were newly or re-referred to the center in 2018. The study sample consisted of 335 subjects with a mean age of 36.0 ± 7.0 years. An increasing number of CSS was significantly correlated with dysmenorrhea, deep dyspareunia, dyschezia, and chronic pelvic pain scores (P < 0.001), and with the CSI score (0-100) (r = 0.731, P < 0.001). Receiver operating characteristic analysis indicated that a CSI cutoff of 40 had a sensitivity of 78% (95% CI: 72.7%-84.6%) and a specificity of 80% (95% CI: 70.3%-84.5%) for identifying a patient with endometriosis with ≥3 CSS. In the group with CSI ≥ 40, 18% retrospectively self-reported pain nonresponsive to hormonal therapy and 40% self-reported daily pain, compared with 6% and 20% in the CSI < 40 group (P = 0.003 and 0.002, respectively). In conclusion, a CSI ≥ 40 may be a practical tool to help identify patients with endometriosis with pain contributors related to central nervous system sensitization.
The role of patient records in research: A bibliometric analysis of publications from an academic medical center in Taiwan
Authors: Li Hui-Chun , Chen Yu-Wen , Chen Tzeng-Ji , Chiou Shih-Hwa , Hwang Shinn-Jang 
Published: May 2021

Background:
This study aimed to assess the use of medical record items in clinical research in one large academic medical center in Taiwan.

Methods:
A descriptive survey design was adopted to collect the data. Articles published in 2018 by Taipei Veterans General Hospital (TVGH) staff as the first author were obtained. The types of specialties and types of research were analyzed. To understand the conditions for the use of medical records, the retrospective research using hospital’s medical records were analyzed. Each article was read in entirety to realize the use and number of patients and the medical record items.

Results:
Among the 362 articles first-authored by TVGH staff in 2018, 219 (60.4%) were classified as clinical studies, 60 (16.6%) as basic studies, 53 (14.6%) as database studies, and 30 (8.2%) as other categories. About 50% of the retrospective research using TVGH medical records had a case number <100 (67 cases, 49.6%) with an average number of 41 cases and 13 studies (9.6%) had a case number >1000. Analysis of the number of medical record items used in 135 retrospective research studies based on TVGH medical records showed that 118 (87.4%) used basic patient information. In addition to basic information, notes written by professionals were used most frequently (73 cases, 54.0%), whereas medication information was used in 50 cases (37.0%); laboratory test data were used in 49 cases (36.2%); and body measurements was used in 27 cases (20%).

Conclusion:
More than one-third of publications utilized medical records, but the patient numbers and record items in use were relatively limited. In the era of digitalization and big data analytics, the potential of medical records in research deserves attention. Investment in establishing a more accessible database of medical records to access nonstructural, descriptive medical records could be considered.
3D Exoscope Navigation-Guided Approach to Middle Cranial Fossa
Authors: Kaul Vivian F. , Fan Caleb J. , Perez Enrique , Schwam Zachary G. , Hadjipanayis Constantinos , Wanna George B. 
Published: May 2021

Objective:
To test the feasibility and efficacy of a 3D exoscope navigation-guided middle cranial fossa (MCF) approach to the internal auditory canal (IAC); to potentially obviate the need to use dissection landmarks and instead, use the navigation probe as a guide to find structures and drill down to the IAC.

Patients:
Cadaveric dissection of six temporal bones.

Intervention:
Computed tomography temporal bone was performed with fiducials on each specimen before the dissection to employ the navigation system. Using a 3D exoscope with navigation by Synaptive (Toronto, Ontario, Canada), the MCF approach was performed.

Main Outcome Measures:
Navigation accuracy, ability to identify critical structures, and ability to drill out the IAC successfully.

Results:
All six specimens had the IAC successfully drilled out using the 3D exoscope. All dissections were performed with navigation and did not require dissecting out the greater superficial petrosal nerve and superior semicircular canal. One specimen used landmark dissection to confirm the IAC after navigation had been used to locate the IAC first. Navigation accuracy mean was 1.86 mm (range, 1.56–2.05 mm).

Conclusion:
A 3D exoscope navigation-guided MCF approach to the IAC is feasible without landmark dissection.
The Quality, Reliability, and Popularity of YouTube Education Videos for Vestibular Rehabilitation: A Cross-sectional Study
Authors: Yildiz Selçuk , Toros Sema Zer 
Published: May 2021

Hypothesis:
Vestibular rehabilitation (VR) education videos on YouTube are poor-quality and unreliable.

Background:
YouTube has become a health information source. Recent studies have determined that videos on YouTube contain misleading and inappropriate information for different medical conditions. The aim of the present study was to assess the quality and reliability of VR education videos.

Methods:
A search was performed using the keywords vertigo, vertigo treatment, vertigo exercise, and vestibular rehabilitation, on YouTube. The first 50 videos for each keyword were analyzed. Videos were divided into four groups according to the video source: Group 1: universities/occupational organizations, Group 2: medical ad/profit-oriented companies, Group 3: independent users, and Group 4: others (news/media/state institution). The quality and reliability of videos were evaluated regarding the modified DISCERN criteria, the modified Journal of the American Medical Association (JAMA) benchmark criteria, and global quality scores (GQS).

Results:
Among the 200 videos analyzed, 103 were included. The main video source was medical ad/profit-oriented companies (60.2%). The mean modified DISCERN criteria score, the mean modified JAMA benchmark criteria score, and the mean GQS value of the videos were found as low (2.46 ± 1.37, 2.09 ± 1.23, and 2.67 ± 1.38, respectively). Videos uploaded by universities/occupational organizations (25.2%) had statistically significant higher modified DISCERN criteria scores, modified JAMA benchmark criteria scores, and GQS values compared with the other groups (p < 0.001).

Conclusion:
Online information about VR education on YouTube was of poor quality and unreliable. Expert vestibular providers should be aware of these inappropriate sources and educate patients regarding the poor-quality of videos and also aim to provide more quality and reliable sources of information.
Detection of Treponema pallidum DNA in Oropharyngeal Swabs and Whole Blood for Syphilis Diagnosis
Authors: Tantalo Lauren C. , Mendoza Haley , Katz David A. , Sahi Sharon K. , Marra Christina M. 
Published: May 2021

Background
Syphilis diagnosis relies on serological tests, which may be falsely nonreactive or may be reactive but not reflect current syphilis.

Methods
Polymerase chain reaction for detection of T. pallidum DNA was performed on 123 oropharyngeal swabs, 120 whole bloods, and 46 lesion exudate swabs from 123 untreated individuals with syphilis (cases); oropharyngeal swabs from 148 at-risk controls without syphilis; and 73 oropharyngeal swabs and 36 whole bloods from 73 individuals recently treated for syphilis.

Results
Most (90.2%) cases had early syphilis. T. pallidum DNA was detected in 33 (26.8%) of 123 oropharyngeal swabs, 32 (26.7%) of 120 bloods, and 30 (65.2%) of 46 lesion exudate swabs. T. pallidum DNA was detected in 49 (40.8%) of 120 individuals in whom both oropharyngeal swabs and blood were tested. T. pallidum was more likely to be amplified from oropharyngeal swabs when it was amplified from blood than when it was not (15 of 32 [46.9%] vs. 17 of 88 [19.3%], P = 0.003). For each 2-fold increase in serum rapid plasma reagin titer, the odds of detection of T. pallidum DNA in oropharyngeal swabs increased by 1.44 (95% confidence interval, 1.14–1.82, P = 0.003). T. pallidum DNA was not detected in oropharyngeal samples from controls, but it was detected in 3 (8.3%) of 36 bloods from individuals recently treated for syphilis: 2 at 1 day and 1 at 5 days after initiation of syphilis treatment.

Conclusions
Nucleic amplification tests can identify recent T. pallidum infection and may be particularly useful for diagnosis of very early or asymptomatic syphilis.
Population-Level Outcomes of Partner Notification Among Gay, Bisexual, and Other Men Who Report Sex With Men Diagnosed With Infectious Syphilis in British Columbia, Canada
Authors: Lukac Christine D. , Consolacion Theodora , Ryan Venessa , Cumming Emma , Mercado Janyn ,   BCCDC Syphilis Nurses, Ford Geoffrey , Ogilvie Gina S. , Gilbert Mark , Grennan Troy , Wong Jason 
Published: May 2021

Background
Syphilis testing, treatment, and partner notification (PN) are centrally coordinated in British Columbia (BC), Canada. Public health (PH) nurses (PHNs) contact almost all syphilis patients and either notify partners of syphilis exposure (PH-initiated PN) or support patients to notify their own partners (patient-initiated PN). In the context of an ongoing syphilis epidemic among gay, bisexual, and other men who report sex with men (gbMSM), we measured population-level yields and compared PN approaches to inform prevention and control efforts.

Methods
All gbMSM diagnosed with infectious syphilis in 2016 in BC were included. We calculated indicators of engagement with PN among patients and PN outcomes among notifiable partners using a cascade-of-care framework. χ2 Tests compared indicators between PN approaches.

Results
Of the 759 syphilis diagnoses, 85.4% (648/759) were among gbMSM and 94.7% (614/648) were treated within 30 days of testing (mean [SD], 5.5 [5.2] days). Among patients, 87.7% (568/648) discussed PN with PHNs and 49.5% (281/568) named at least 1 notifiable partner, for a total of 1094 partners (mean [SD], 3.9 [5.5] partners/patient). Compared with PH-initiated PN, patient-initiated PN resulted in a greater proportion of partners notified (70.1% [573/817] vs. 89.8% [211/235]; P = 1.88 × 10−9), but there was no difference in the proportion of partners tested and/or treated (90.2% [517/573] vs. 86.7% [183/211]; P = 0.203), and diagnosed (12.8% [66/517] vs. 16.4% [30/183]; P > 0.271).

Conclusions
Public health– and patient-initiated PN had similarly high yields of partners tested and/or treated, and diagnosed, demonstrating that gbMSM can contribute to syphilis PN when supported by resource-equipped PHNs.