bluuebunny/crossref_metadata_2025_split huggingface dataset:
Play therapy in the prevention of behavioural disorders of school-aged children
Authors: Maras Andrej 
Published: August 2021

The main goal of this research was to identify and understand the effects of play therapy on the prevention of behavioural disorders of younger school-aged children. A semi-structured interview was used as the data collection method with 17 open-ended questions. The study participants were seven parents whose children were involved in play therapy treatment for at least 3 months. It has been shown that play therapy is an effective medium in empathy development, more successful emotion management, encouragement of non-violent communication and reduction in aggressive behaviour. It can be concluded that the effectiveness of play therapy in the prevention of behavioural disorders significantly depends on the involvement of parents in treatment and the relationship between a therapist and a child. This research certainly serves as a basis for further research that will recognise the importance of therapeutic play in solving emotional and/or behavioural difficulties of children and youth.

Keywords: Behavioural disorders, child, play therapy, prevention.
La segunda residencia: espacios fragmentados e interconectados
Authors: Gómez Contreras Luz Mery 
Published: August 2021

Un fenómeno que evidencia la rururbanización es el de la segunda residencia, considerada una forma de urbanización del campo, por lo que se constituye en un instrumento de difusión y dispersión de la ciudad sobre el espacio rural. Las nuevas periferias metropolitanas aparecen como los territorios modelo de la ciudad dispersa, con una discontinuidad espacial marcada, conformados por piezas separadas físicamente, pero integradas por medio de redes. Allí se diluyen los principios de proximidad y contigüidad, y opera la lógica de la organización en red, donde priman conexidad y conectividad.Palabras cave: Fragmentación,Rururbanización, Segunda residencia.
Asbtract A phenomenon that shows the rural-urbanization is the second home or second residence, considered a form of urbanization of the countryside, which becomes a tool for the dissemination and spread out of the city over the countryside. The new metropolitan peripheries appear as the territories of the dispersed city model, with a marked spatial discontinuity,comprised of physically separate parts but integrated through networks. There, the principles of proximity and contiguity are diluted, and the logic of network organization operates whereindustry connectedness and connectivity are of primary mportance.
Key words:Fragmentation, Rural-urbanization, Second home/Second Residence.
Estado del arte del sector económico del medio ambiente
Authors: Otero Gómez Carol Johanna 
Published: August 2021

La creciente preocupación por el deterioro ambiental causado por la acción del hombre ha generado el surgimiento de una serie de actividades ambientales empresariales que buscan mitigar dichos impactos, hoy ya se habla en algunos países europeos del sector económico emergente del medio ambiente. En nuestro país el tema se encuentra poco explorado y por ello se plantea la realización del estado del arte del sector económico del medio ambiente en Europa y Colombia, identificando los hitos que dieron origen al sector y las variables económicas y sociales que influyeron en su desarrollo, además de establecer como se encuentra Colombia en materia económica ambiental.
A Data Processing Method Based on Sequence Labelling and Syntactic Analysis for Extracting New Sentiment Words from Product Reviews
Authors: Zhang Shunxiang , Xu Han qing , Zhu Guang li , Chen Xiang , Li Kuang Ching 
Published: August 2021

Abstract
New sentiment words in product reviews are valuable resources that are directly close to users. The data processing of new sentiment word extraction can provide information service better for users, and provide theoretical support for the related research of edge computing. Traditional methods for extracting new sentiment words generally ignored the context and syntactic information, which leads to the low accuracy and recall rate in the process of extracting new sentiment words. To tackle the mentioned issue, we proposed a data processing method based on sequence labeling and syntactic analysis for extracting new sentiment words from product reviews. Firstly, the probability that the new word is a sentiment word is calculated through the location rules derived from the sequence labeling result, and the candidate set of new sentiment words is obtained according to the probability. Then, the candidate set of new sentiment words is supplemented with the method of matching appositive words based on edit distance. Finally, the final set of new sentiment words is collected through fine-grained filtering, including the calculation of Point Mutual Information (PMI) and difference coefficient of positive and negative corpus (DC-PNC). The experimental results illustrate the effectiveness of new sentiment words extracted by the proposed method which can obviously improve the accuracy and recall rate of sentiment analysis.
Protective Effects of Oral Vitamin C on Memory and Learning Impairment and Attenuation of Synaptic Plasticity induced by Intracerebroventricular Injection of Beta-amyloid Peptide in Male Rats
Authors: Sattari Shima , Vaezi Gholamhasan , Shahidi Siamak , Hojati Vida , Komaki Alireza 
Published: August 2021

Abstract
Background: In neurodegenerative diseases, like Alzheimer’s disease (AD), learning and memory, and neural plasticity are impaired. Vitamin C (Vit C), as an antioxidant, protects tissues against oxidative stress. In this study, the neuroprotection and the effectiveness of Vit C in the prevention and treatment of AD in a rat model of AD induced by intracerebroventricular (ICV) injection of amyloid-beta (Aβ) were studied using behavioral tests and electrophysiological methods. Methods: 50 male Wistar rats were randomly assigned to five groups (n=10 rats /group): Control, Sham, AD, Vit C, and AD+Vit C. After treatment (2 months), animals were assessed by learning and memory tests, including the new object recognition (NOR), passive avoidance learning (PAL), and Morris water maze (MWM) tests. Then, using the electrophysiological method, synaptic plasticity in the hippocampus was assessed and Vit C effects on long-term potentiation (LTP) were examined.Results: ICV injection of Aβ to the AD group reduced memory in the NOR, PAL, and MWM behavioral tests. Also, Vit C reduced learning and memory impairment due to Aβ injection in rats. Aβ caused the inhibition of LTP in dentate gyrus (DG) granule cells by reducing the slope of the excitatory postsynaptic potential (EPSP) and the amplitude of the population spike (PS) in the AD group. Conclusions: These results showed that Vit C reduced the impairment in synaptic plasticity induced by Aβ in DG of the hippocampus. Vit C supplementation through its antioxidant properties can improve the impaired synaptic plasticity and memory induced by Aβ and can be applied as a neuroprotective agent.
Mental health of Covid-19 risk groups during the first Covid-19 lockdown in Germany: a cross-sectional study
Authors: Deimel Daniel , Köhler Thorsten , Dyba Janina , Graf Niels , Firk Christine 
Published: August 2021

Abstract
Background

The ongoing Covid-19 pandemic not only threats physical health, but also affects the mental health of people. Yet, health consequences of the pandemic do not affect all members of society equally. We, therefore, assessed the mental health burden of individuals who are at increased risk of severe illness from Covid-19 compared to individuals who are at low risk of severe illness during the first lockdown in Germany. Furthermore, we investigated variables mediating the effect of being an individual at increased risk of serve illness on depression.
Methods

Adult German residents (n = 2.369) provided responses to a cross-sectional online survey about risk factors for an increased risk of severe illness from Covid-19 and various aspects of mental health during the first Covid-19 lockdown in Germany. Standardized and validated self-report measures (e.g. PHQ-9, GAD-7) were used using Mann-Whitney U-tests as well as regression and mediation analyses.
Results

The results clearly show that the mental health burden is higher among persons at increased risk of severe illness from Covid-19 compared to persons at low risk of severe illness from Covid-19. Moreover, our findings indicate that individuals at increased risk of severe illness are more worried about their health during the pandemic and may therefore respond with social withdrawal to protect themselves and, consequently, experience higher levels of loneliness, which in turn has an impact on depressive symptoms.
Conclusions

Individuals at increased risk of severe illness have an increased need for psychosocial support during times of lockdown. Future public health policies should pay special attention to these individuals and support them by targeted offers. More research, however, is needed on possible long-term consequences of social distancing on mental health.
Memantine Augmentation of Sertraline in Severity of Symptoms and Cognitive Function Among Patients with Obsessive-Compulsive Disorder: A Double-Blind Placebo-Controlled, Randomized Clinical Trial
Authors: Askari Sanaz , Mokhtari Saba , Shariat Seyed Vahid , Shariati Behnam , Yarahmadi Masoomeh , Shalbafan Mohammadreza 
Published: August 2021

Abstract
Background: Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually decrease the severity of the symptoms by 20–30%, and 40–60% of OCD patients do not achieve satisfactory treatment. In this study, the main objective was to investigate the effectiveness of memantine, which is a non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist, as an adjunct therapy to sertraline, a selective serotonin reuptake inhibitor (SSRI), to improve severity of symptoms and cognitive function among patients with obsessive-compulsive disorder. Methods: 70 patients who based on Diagnostic and Statistical Manual of Mental Disorders (DSM–5) criteria were diagnosed with OCD, and had a Yale-Brown obsessive compulsive scale (Y-BOCS) score of more than 21, were recruited in a placebo controlled, double-blinded, parallel-group, clinical trial of 12 weeks to receive either memantine (10 mg twice daily) and sertraline (100 mg daily initially followed by 200 mg daily after week 4) or placebo and sertraline. The primary outcome was OCD symptoms measured by the Y-BOCS, moreover, the executive function and the cognition of participants was measured by the Wisconsin Card Sorting Test (WCST).Results: Y-BOCS score in total, obsession and compulsion subscales significantly dropped in both groups; however, there was not a significant difference between them. In comparison of cognition, memantine group showed a greater response in number of categories subscale in the WCST (p value<0.001). No major adverse effects were observed in any of the groups. Conclusion: Our findings suggest a probable effect of memantine as adjuvant therapy to sertraline on cognitive function of patients with OCD as well as its safety and tolerability in comparison with placebo. Nevertheless, the current results don`t support the efficacy of memantine as an adjunctive agent to sertraline for improving severity of symptoms among patients with OCD.Trial registration: The trial was registered at the Iranian Registry of Clinical Trials on 2019-10-04 (www.irct.ir; IRCT ID: IRCT20170123032145N4).
A Qualitative Analysis of Barriers and Facilitators to Referral Care for High-Risk Pregnant Women in Rural Rajasthan, India
Authors: Dalal Saachi , Nagar Ruchit , Hegde Rohaan , Vaishnav Surya , Abdullah Hamid , Kasper Jennifer 
Published: August 2021

Abstract
Objective
If Rajasthan, India was a country, it would rank 148th out of 192 for maternal mortality. Early identification of high-risk pregnant women, timely referral care, early intervention and delivery planning are key factors in reducing maternal mortality. To our knowledge, this is the first study to qualitatively assess the barriers and facilitators to uptake of referral services amongst high-risk pregnant women in rural Rajasthan.
Methods
Active pregnant women tracked digitally through the Khushi Baby platform in Udaipur, Rajasthan were considered from the sample frame. Pregnant women who had either severe hypertension or moderate/severe anemia were considered for inclusion. A purposive sample was approached to ensure a diversity of perspectives. In-depth individual interviews were conducted in the local dialect, Mewari. Interviews were transcribed, coded, and used for thematic generation, and organized as per the analytical framework described in the socio-ecological model.
Results
19 high risk pregnant women of low socioeconomic backgrounds across 15 villages were interviewed. Barriers to referral care included lack of transportation, household responsibilities, and limited awareness, education, and social support. The most prominent barrier was lack of accompaniment to the referral center by a family member or health worker. Facilitators included available husbands, engaged heath workers, supportive neighbors, and other female family members who shared past experiences. Social support through accompaniment was noted to have the ability to overcome barriers.
Conclusions
Social support at the interpersonal and community level is key to overcoming referral care barriers faced by high-risk pregnant women in rural Rajasthan. Completion of antenatal referral care visits is essential to improvement in maternal and child health outcomes. A multi-faceted approach is needed to improve referral care completion for maternal health in rural Rajasthan. The following interventions are likely to be effective: a) targeted awareness campaigns for ambulance availability for high-risk conditions; b) digital tools to improve planning and coordination among health workers; c) inclusion of screening indicators for social isolation as a risk factor; and d) incentivization of beneficiaries for referral completion. We are in the process of sharing these findings with the district and state government of Rajasthan.
Prevalence of SARS-CoV-2 Antibodies in Hemodialysis Patients in Senegal: A Multicenter Cross-Sectional Study
Authors: Seck Sidy Mohamed , Mbow Moustapha , Kane Yaya , Cisse Mouhamadou Moustapha , Faye Gnagna , Kama Adama , Sarr Moussa , Nitcheu Pamela , Dahaba Mohamed , Diallo Ibrahima Mbemba , Diawara Mame Selly , Latou Lotingo Nehemie Motoula , Dia Yacine , Mboup Souleymane 
Published: August 2021

Abstract
BackgroundHemodialysis patients are among high-risk groups for COVID-19. Africa is the continent with the lowest number of cases in the general population but we have little information about the disease burden in dialysis patients. Objectives:This study aimed to describe the seroprevalence of SARS-CoV-2 antibodies in the hemodialysis population of Senegal.Patients and methodsWe conducted a multicenter cross-sectional survey, between June and September 2020 involving 10 public dialysis units randomly selected in eight regions of Senegal. After seeking their consent, we included 303 patients aged ≥18 years and hemodialysis for ≥3 months. Clinical symptoms and biological parameters were collected from medical records. Patients’ blood samples were tested with Abbott SARS-CoV-2 Ig G assay using an Architect system. Statistical tests were performed with STATA 20.ResultsSeroprevalence of SARS-CoV-2 antibodies was 21.1% (95% CI= 16.7%-26.1%). We noticed a wide variability in SARS-CoV-2 seroprevalence between regions ranging from 5.6% to 51.7%. Among the 38 patients who underwent nasal swab testing, only six patients had a PCR-confirmed infection and all of them did seroconvert. Suggestive clinical symptoms were reported by 28.1% of seropositive patients and the majority of them presented asymptomatic disease. After multivariate analysis, a previous contact with a confirmed case and living in a high population density region were associated with the presence of SARS-CoV-2 antibodies.ConclusionThis study presents to our knowledge the first seroprevalence data in African hemodialysis patients. Compared to data from other continents, we found a higher proportion of patients with SARS-CoV-2 antibodies but a lower lethality rate.
Indirect Meta-Analysis of Brexpiprazole Versus Aripiprazole in the Acute Treatment of Schizophrenia
Authors: Seifritz Erich , Friede Michael , Schnitker Jörg 
Published: August 2021

Abstract
Background: Brexpiprazole and aripiprazole are atypical antipsychotics that act as partial agonists at the dopamine D2 receptor. No head-to-head trial comparing brexpiprazole and aripiprazole in the treatment of schizophrenia is available. Here, we carry out a systematic review and comparison of the efficacy and safety of brexpiprazole and aripiprazole in schizophrenia treatment.Methods: We employed an indirect meta-analysis to determine effect sizes from randomised placebo-controlled trials with brexpiprazole and aripiprazole in the acute treatment of schizophrenia. We compared responder rates, incidences of adverse events and serious adverse events, the number needed to treat (NNT) for response, number needed to harm (NNH) for adverse events or treatment discontinuation, and likelihood to be helped or harmed (LHH) as efficacy and safety indices of the two drugs. Results: Five studies for each drug were included in the analysis. Similar risk differences vs. placebo were observed for responder rates under brexpiprazole (10.2%, p = 0.0015) and aripiprazole (10.3%, p = 0.0003). Higher incidences of adverse events and serious adverse events were seen under aripiprazole compared with brexpiprazole, however, the risk differences were not statistically significant. The NNT for response was 11 for both substances. For brexpiprazole compared with placebo, we did not find an increase of adverse events (NNH = 27, not significant), however, we found an increased number of adverse events for aripiprazole versus placebo (NNH = 17, p < 0.05). For both drugs, benefits were encountered more often than harms, with an LHH for any adverse event of 2.41 for brexpiprazole and 1.56 for aripiprazole, respectively. Conclusions: The likelihood to be helped rather than harmed was greater with brexpiprazole compared to aripiprazole for the total rate of adverse events (ratio of brexpiprazole LHH/aripiprazole LHH = 1.54).
Biases and Improvements of the ENSO- East Asian Winter Monsoon Teleconnection in CMIP5 and CMIP6 Models
Authors: Jiang Wenping , Gong Hainan , Huang Ping , Wang Lin , Huang Gang , Hu Lisuo 
Published: August 2021

Abstract
The influence of El Niño–Southern Oscillation (ENSO) on the East Asian winter monsoon (EAWM) is investigated based on the outputs of phase 6 of the Coupled Model Intercomparison Project (CMIP6) models and compared to that in phase 5 (CMIP5). Results show that the CMIP6 models generally reproduce the ENSO-EAWM teleconnection more realistically than the CMIP5 models, although they still somewhat underestimate the ENSO-EAWM teleconnection than observed. Based on the inter-model spread of ENSO-EAWM teleconnection simulated in the CMIP5/CMIP6 models, we reveal that the commonly underestimated ENSO-EAWM teleconnection among the models can be traced back to the excessive cold tongue bias in the equatorial western Pacific. A model with a stronger climatological cold tongue favors generating a more westward extension of the ENSO-related SST anomaly pattern, which in turn forces an anomalous cyclonic circulation over the Northwest Pacific (NWP). It offsets the anticyclonic anomalies in the NWP triggered by the warm ENSO-related SST anomalies in the tropical Indian Ocean and the central-eastern Pacific and weakens the ENSO-EAWM teleconnection. Compared with the CMIP5 models, CMIP6 models better simulate SST mean state and the resultant ENSO-EAWM teleconnection. The present results suggest that substantial efforts should be made to reduce the bias in the mean-state SST for further improving the simulation and projection of the East Asian-western Pacific winter climate.
Comparative Study about the Efficacy of Low Level Laser Therapy and Curcumin Antimicrobial Photodynamic Therapy as a Coadjuvant Treatment of Oral Mucositis in Oncologic Patients:Antimicrobial, Analgesic and Degree Alteration Effect.
Authors: Andrade Rita de Cássia Dias Viana , REIS THAIS AZEVEDO , Rosa Luciano Pereira , Santos Gabriel Pinto de Oliveira , Silva Francine Cristina da 
Published: August 2021

Abstract
INTRODUCTION: As conventional treatments currently available for mucositis are not considerably effective,there is a need to implement an adjuvant protocol for the treatment of oral mucositis in patients undergoing radiotherapy and chemotherapy.PURPOSE: To evaluate the effect of Low Level Laser Therapy and Antimicrobial Photodynamic Therapy mediated by curcumin and blue LED as an adjunct treatment of oral mucositis foroncology patients using chemotherapy and or radiotherapy.METHODS: Clinical, randomized study, in a single location, in an oncology service of a general hospital, with a total of 30 patients (over 18 years old) with stable oral mucosa lesions in the process of Chemotherapy and or Radiotherapy. The patients were divided into 3 groups: Control group (treated with nystatin), LLLT group (treated with Low Level Laser Therapy), and the aPDT group (treated with 450 nm blue LED and curcumin photosensitizer).RESULTS: The results showed, by means of intra-group comparisons, that the two experimental treatments promoted yeast reduction of the genus Candida in the last two evaluations (21 days and 30 days), but not in the first two evaluations (7 days and 14 days). The intra-group comparisons showed that the Control and aPDT group showed a significant difference in the degree of mucositis over the four evaluations performed, with the results pointing out that the mucositis worsened in the control group from the 14th day, while reduced in the aPDT group from the 21st day of treatment.CONCLUSION: A reduction in the degree of mucositis and pain score was observed in the LLLT and aPDT groups, with the aPDT group standing out when presenting early clinical improvement in relation to the LLLT group and the control group, thus emphasizing its effectiveness within the desired aspects. Regarding the antimicrobial effect, aPDT showed a greater reduction of yeasts of the genus Candida in the tested parameters.