bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acoustic Möbius insulators from projective symmetry
Authors: Qiu Chunyin , Li Tianzi , Du Juan , Zhang Qicheng , Li Yitong , Fan Xiying , Zhang Fan 
Published: July 2021

Abstract
Symmetry plays a critical role in classifying phases of matter. This is exemplified by how crystalline symmetries enrich the topological classification of materials and enable unconventional phenomena in topologically nontrivial ones. After an extensive study over the past decade, the list of topological crystalline insulators and semimetals seems to be exhaustive and concluded. However, in the presence of gauge symmetry, common but not limited to artificial crystals, the algebraic structure of crystalline symmetries needs to be projectively represented, giving rise to unprecedented topological physics. Here we demonstrate this novel idea by exploiting a projective translation symmetry and constructing a variety of Möbius-twisted topological phases. Experimentally, we realize two Möbius insulators in acoustic crystals for the first time: a two-dimensional one of first-order band topology and a three-dimensional one of higher-order band topology. We observe unambiguously the peculiar Möbius edge and hinge states via real-space visualization of their localiztions, momentum-space spectroscopy of their 4π periodicity, and phase-space winding of their projective translation eigenvalues. Not only does our work open a new avenue for artificial systems under the interplay between gauge and crystalline symmetries, but it also initializes a new framework for topological physics from projective symmetry.
A novel adsorbent features like EDTA synthesized in situ by chemically modified cellulose and its behavior in metal ions adsorption from aqueous solution
Authors: Hu Tao , Hu Xiaoli , Tang Cheng , Liu Dan 
Published: July 2021

Abstract
This paper describes the synthesis of a novel chelating material derived from cellulose, and its heavy metal ions adsorption behavior from aqueous solution. The first section of this paper reports the chemical grafting of cellulose, that aminoacetic acid groups were grafted into the cellulose, resulted a novel yet unreported modified cellulose derivative N,N-(dicarboxymethylaminoethyl, carboxymethyl) aminoethylamine carboxymethyl cellulose amide. This obtained adsorbent was characterized by elemental analysis, infrared spectroscopy (IR) and Solid State Nuclear Magnetic Resonance (SSNMR) 13 C NMR spectroscopy. In the second section, adsorption behaviors such as kinetic study, adsorption isotherms of the adsorbent for Cu 2+ and Pb 2+ single metal ions from aqueous solution, and adsorption capacity for Ba 2+ , Mg 2+ , Mn 2+ , Co 2+ , Zn 2+ , Pb 2+ , Ni 2+ and Cu 2+ , and the competitive adsorption of this adsorbent between ions were evaluated by ICP spectroscopy.
In vivo optogenetics reveals control of cochlear sensitivity by supporting cells
Authors: Lukashkina Victoria , Levic Snezana , Simões Patricio , Xu Zhenhang , DiGuiseppi Joseph , Zuo Jian , Lukashkin Andrei , Russell Ian 
Published: July 2021

Abstract
Cochlear sensitivity, essential for communication and exploiting the acoustic environment, is due to the sensory-motor outer hair cells (OHCs) that operate in the structural scaffold of supporting cells and extracellular spaces in the cochlear organ of Corti (OoC). It is unclear whether supporting cells (e.g., Deiters cells [DCs] and outer pillar cells [OPCs]) control cochlear sensitivity in vivo. Here we employed optogenetics to measure in vivo sound-induced cochlear mechanical and electrical responses, and ex vivo light-induced DC electrical responses in the OoC of mice that conditionally expressed channelrhodopsins (ChR2) specifically in DCs and OPCs. Illumination activated a nonselective ChR2 cation conductance and depolarized the DCs. This transient action reversibly blocked continuous, normally occurring, minor adjustments of tone-evoked basilar membrane displacements, and OHC voltage responses to tones at and close to their characteristic frequency, and speeded recovery from temporary acoustic desensitization. This is the first direct evidence for the interdependency of the structural, mechanical, and electrochemical arrangement of OHCs and OoC supporting cells which together fine control cochlear sensitivity.
PENGARUH PROFITABILITAS DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN MANUFAKTUR DENGAN DIVIDEN SEBAGAI MEDIASI
Authors: Dete Yunita , Erawati Teguh 
Published: July 2021

ABSTRAKPenelitian ini bertujuan untuk menguji pengaruh profitabilitas dan ukuran perusahaan terhadap nilai perusahaan dengan kebijakan dividen sebagai variabel mediasi pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI). Data yang digunakan dalam penelitian ini adalah data sekunder. Populasi yang digunakan adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2018. Sampel penelitian sebanyak 19 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI). Teknik pengumpulan data menggunakan metode purposive sampling. Analisis data menggunakan uji asumsi klasik, analisis regresi linier berganda, analisis jalur. Hasil penelitian menunjukkan bahwa profitabilitas berpengaruh positif signifikan terhadap kebijakan dividen. Ukuran perusahaan berpengaruh positif signifikan terhadap kebijakan dividen. Kebijakan dividen berpengaruh positif signifikan terhadap nilai perusahaan. Profitabilitas berpengaruh positif signifikan terhadap nilai perusahaan. Ukuran perusahaan berpengaruh positif signifikan terhadap nilai perusahaan. Kata kunci: profitabilitas, ukuran perusahaan, kebijakan dividen, nilai perusahaan ABSTRACTThis study aims to examine the effect of profitability and company size on firm value with dividend policy as a mediating variable in manufacturing companies listed on the Indonesia Stock Exchange (BEI). The data used in this research is secondary data. The population used is manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the period of 2016-2018. The research sample of 19 manufacturing companies listed on the Indonesia Stock Exchange (IDX). Data collection techniques using purposive sampling method. Data analysis using the classical assumption test, multiple linear regression analysis, path analysis. The results showed that profitability had a significant positive effect on dividend policy. The size of the company has a significant positive effect on dividend policy. Dividend policy has a significant positive effect on firm value. Profitability has a significant positive effect on firm value. Company size has a significant positive effect on firm value. Keywords: profitability, company size, dividend policy, company value
PENGARUH KUALITAS PRODUK, PERSEPSI HARGA, DAN KUALITAS LAYANAN TERHADAP KEPUASAN KONSUMEN
Authors: Herdioko Jonathan , W Valentcio Luwiska 
Published: July 2021

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk, persepsi harga, dan kualitas pelayanan terhadap kepuasan konsumen pada Toko Tekstil Mac Mohan, Solo. Populasi dalam penelitian ini adalah penduduk Kota Solo. Teknik penyampelan menggunakan non-probability sampling dengan pemilihan 100 responden yang pernah membeli produk di Mac Mohan Solo. Teknik pengumpulan data dilakukan dengan menyebarkan kuesioner yang telah diuji validitas dan reliabilitasnya. Metode analisis regresi linier berganda digunakan dengan uji R2, uji F, dan uji t. Hasil pengujian menghasilkan nilai sig uji F sebesar = 0,00, artinya secara simultan variabel kualitas produk, persepsi harga, dan kualitas pelayanan berpengaruh signifikan terhadap kepuasan konsumen. Hasil uji t menunjukkan bahwa kualitas produk, persepsi harga, dan kualitas layanan secara parsial berpengaruh signifikan terhadap kepuasan pelanggan. Kata Kunci: kualitas produk, persepsi harga, kualitas layanan, kepuasan pelanggan ABSTRACTThis study aims to determine the effect of product quality, price perception, and service quality toward customer satisfaction at Toko Tekstil Mac Mohan, Solo. The population in this study are the residents of Solo. Non-probability sampling method is adopted with a selection of 100 respondents who have bought products at Mac Mohan Solo. Data collection techniques were carried out by distributing questionnaires that had been tested for validity and reliability. The multiple linear regression analysis method is used with R2 test, F test, and t test. The test results produce a sig value of F test of = 0.00, meaning that simultaneously, the variable product quality, price perception, and service quality have a significant effect on customer satisfaction. The t test shows that product quality partially, price perception, and service quality partially have a significant effect on customer satisfaction. Keywords: product quality, price perception, service quality, customer satisfaction
Editorial Volumen 13-2
Authors: Reyes Sebastian Camilo , Reyes Guzmán Sebastián Camilo 
Published: July 2021

“La violencia no es una entidad ontológica: es unaacusación […] la legitimación de la violencia hace que éstaresulte invisible; por ejemplo, un acto de agresión físicarealizado en defensa propia no es percibido como violento.Cuando la violencia es visible o, más exactamente, cuandoes pronunciable recibe la acusación de ilegitimidad. Ésta esla razón que hace que la violencia constituya un rasgo quecaracteriza al otro; forma parte de la enajenación del otro”.(Renzo Taddei, 2016, p.17)
La revista Criterios, Cuadernos de Ciencias Jurídicas y Política Internacional, presenta su ejemplar número veintiséis, en el que desarrolla un marco de análisis en relación con dos líneas temáticas de gran envergadura y pertinencia, ambas, estrechamente vinculadas con las dinámicas sociales y las relaciones de poder entre la sociedad civil y la fuerza pública, mediadas a través de un escenario de disputas, desencadenamiento de conflictividades y el uso de la violencia como un mecanismo de pacificación, ese espacio de interlocución y efervescencia, no es otro que la protesta social. En ese sentido, la protesta social en los años recientes para el caso de Colombia se ha configurado como una instancia para tramitar el resquemor, malestar y la disensión por parte de uno o varios sectores de la sociedad ante los direccionamientos políticos y económicos gubernamentales, -como el lugar aciago que ostenta Colombia cuando se examinan los resultados de los últimos años del Indicador de Gini publicado por el Banco Mundial y paralelamente otros estudios sobre inequidad socioeconómica como el Índice de Desarrollo Regional para Latinoamérica, el cual ubica a Colombia como el país más desigual de América Latina en el 2020, -o el caso de la alarmante situación en materia de los Derechos Humanos...(los invitamos a consultar la versión completa en pdf)
Hybrid optimization model for conjunctive use of surface and groundwater resources in water deficit irrigation system
Authors: Sampathkumar Karthikeyan Moothampalayam , Ramasamy Saravanan , Ramasubbu Balamurugan , Karuppanan Saravanan , Lakshminarayanan Balaji 
Published: July 2021

Abstract
The increasing demand for food production with limited available water resources poses a threat to agricultural activities. Conventional optimization algorithms increase the processing stage and perform in the space allocated from user. Therefore, the proposed work was used to design better performance results. The conjunctive allocation of water resources maximizes the net benefit of farmers. In this study, the novel hybrid optimization model developed is the first of its kind and was designed to resolve the sharing of water resource conflict among different reaches based on a genetic algorithm (GA), bacterial foraging optimization (BFO) and ant colony optimization (ACO) to maximize the net benefit of the water deficit in Sathanur reservoir command. The GA-based optimization model considered crop-related physical and economic parameters to derive optimal cropping patterns for three different conjunctive use policies and further allocation of surface and groundwater for different crops are enhanced with the BFO. The allocation of surface and groundwater for the head, middle and tail reaches obtained from the BFO is considered as an input to the ACO as a guiding mechanism to attain an optimal cropping pattern. Comparing the average productivity values, policy 3 (3.665 Rs/m3) has better values relating to policy 1 (3.662 Rs/m3) and policy 2 (3.440 Rs/m3). Thus, the developed novel hybrid optimization model (GA-BFO-ACO) is very promising for enhancing farmer's net income and can be replicated in other irrigated regions to overcome chronic water problems. The productivity value of policy 3 was 6.54% greater than that of policy 2, whereas that of policy 1 was 6.45% greater. Overall, the comparison shows that the better performance analysis of various optimization was done successfully.
COVID-19 Data Utilization in North Carolina: Qualitative Analysis of Stakeholder Experiences
Authors: Patterson Jenny Rees , Shaw Donna , Thomas Sharita R , Hayes Julie A , Daley Christopher R , Knight Stefania , Aikat Jay , Mieczkowska Joanna O , Ahalt Stanley C , Krishnamurthy Ashok K 
Published: July 2021

BackgroundAs the world faced the pandemic caused by the novel coronavirus disease 2019 (COVID-19), medical professionals, technologists, community leaders, and policy makers sought to understand how best to leverage data for public health surveillance and community education. With this complex public health problem, North Carolinians relied on data from state, federal, and global health organizations to increase their understanding of the pandemic and guide decision-making.ObjectiveWe aimed to describe the role that stakeholders involved in COVID-19–related data played in managing the pandemic in North Carolina. The study investigated the processes used by organizations throughout the state in using, collecting, and reporting COVID-19 data.MethodsWe used an exploratory qualitative study design to investigate North Carolina’s COVID-19 data collection efforts. To better understand these processes, key informant interviews were conducted with employees from organizations that collected COVID-19 data across the state. We developed an interview guide, and open-ended semistructured interviews were conducted during the period from June through November 2020. Interviews lasted between 30 and 45 minutes and were conducted by data scientists by videoconference. Data were subsequently analyzed using qualitative data analysis software.ResultsResults indicated that electronic health records were primary sources of COVID-19 data. Often, data were also used to create dashboards to inform the public or other health professionals, to aid in decision-making, or for reporting purposes. Cross-sector collaboration was cited as a major success. Consistency among metrics and data definitions, data collection processes, and contact tracing were cited as challenges.ConclusionsFindings suggest that, during future outbreaks, organizations across regions could benefit from data centralization and data governance. Data should be publicly accessible and in a user-friendly format. Additionally, established cross-sector collaboration networks are demonstrably beneficial for public health professionals across the state as these established relationships facilitate a rapid response to evolving public health challenges.
Early Experience With Neutralizing Monoclonal Antibody Therapy for COVID-19: Retrospective Cohort Survival Analysis and Descriptive Study
Authors: Jarrett Mark , Licht Warren , Bock Kevin , Brown Zenobia , Hirsch Jamie , Coppa Kevin , Brar Rajdeep , Bello Stephen , Nash Ira 
Published: July 2021

Background
Neutralizing monoclonal antibody (MAB) therapies may benefit patients with mild to moderate COVID-19 at high risk for progressing to severe COVID-19 or hospitalization. Studies documenting approaches to deliver MAB infusions and demonstrating their efficacy are lacking.

Objective
We describe our experience and the outcomes of almost 3000 patients who received MAB infusion therapy at Northwell Health, a large integrated health care system in New York.

Methods
This is a descriptive study of adult patients who received MAB therapy between November 20, 2020, to January 31, 2021, and a retrospective cohort survival analysis comparing patients who received MAB therapy prior to admission versus those who did not. A multivariable Cox model with inverse probability weighting according to the propensity score including covariates (sociodemographic, comorbidities, and presenting vital signs) was used. The primary outcome was in-hospital mortality; additional evaluations included emergency department use and hospitalization within 28 days of a positive COVID-19 test for patients who received MAB therapy.

Results
During the study period, 2818 adult patients received MAB infusion. Following therapy and within 28 days of a COVID-19 test, 123 (4.4%) patients presented to the emergency department and were released, and 145 (5.1%) patients were hospitalized. These 145 patients were compared with 200 controls who were eligible for but did not receive MAB therapy and were hospitalized. In the MAB group, 16 (11%) patients met the primary outcome of in-hospital mortality, versus 21 (10.5%) in the control group. In an unadjusted Cox model, the hazard ratio (HR) for time to in-hospital mortality for the MAB group was 1.38 (95% CI 0.696-2.719). Models adjusting for demographics (HR 1.1, 95% CI 0.53-2.23), demographics and Charlson Comorbidity Index (HR 1.22, 95% CI 0.573-2.59), and with inverse probability weighting according to propensity scores (HR 1.19, 95% CI 0.619-2.29) did not demonstrate significance. The hospitalization rate was 4.4% for patients who received MAB therapy within 0 to 4 days, 5% within 5 to 7 days, and 6.1% in ≥8 days of symptom onset (P=.15).

Conclusions
Establishing the capability to provide neutralizing MAB infusion therapy requires substantial planning and coordination. Although this therapy may be an important treatment option for early mild to moderate COVID-19 in patients who are at high risk, further investigations are needed to define the optimal timing of MAB treatment to reduce hospitalization and mortality.
Deteksi Lokasi Parkir Kendaran Menggunakan ATMega 16 dan Modul GPS
Authors: Tjahjadi Gunawan , Dwi Cahya Nugraha , Yenita Nur Rahma , Alam Syah 
Published: July 2021

Penelitian ini mengusulkan sistem deteksi parkir mobil menggunakan ATMega16 dengan modul GPS. Sensor inframerah digunakan untuk mendeteksi lokasi parkir yang kosong yang selanjutnya diproses oleh ATMega 16 untuk diteruskan ke modul GPS. Modul GPS berfungsi untuk menunjukkan lokasi parkir yang kosong dan ditunjukkan dengan indikator lampu LED. Dari hasil perancangan dan pengujian didapatkan bahwa sitem yang dirancang telah berhasil mendeteksi dan mengarahkan kendaraan menuju ke lokasi parkir yang kosong. Penelitian ini dapat direkomendasikan sebagai sistem parkir otomatis untuk gedung perkantoran.
Rubia cordifolia (Manjishtha): A review based upon its Ayurvedic and Medicinal uses
Authors: Kumari Isha , Kaurav Hemlata , Choudhary Gitika 
Published: July 2021

Medicinal herbs have a rich history of their utilization for variety of ailments. India is categorized among those countries which have produced vast variety of medicinal plants. India is also called as “Botanical garden of the world”. Medicinal plants are the source of discovery of new drugs across the world. Most of the drugs available today have some herbal content of plants in them. Rubia Cordifolia (Manjishtha) is a climber herb having small flowers of greenish white colour which are grouped around the purplish fleshy fruits. The roots of Rubia cordifolia imparts red colour from where dye is obtained which is due to the presence of brownish red bark. This plant is mainly cultivated in the hilly areas. Manjishtha has a very significant place in Ayurveda which is one of the most ancient health care systems of the world. Charaka categorized this medicinal herb as varnya (for the enhancement of skin complexion), jvarahara (anti-pyretic), visaghna (a detoxifier) and a rasayana (rejuvenator). While it is categorized as pittasamsamana (one which maintains the pitta dosha of the body i.e. the fire component of the body) by Acharya Sushrut. Manjishtha has potential to pacifiy the pitta dosha. The phytochemical constituents of Rubia Cordifolia (Manjishtha) are associated with wide range of therapeutic properties. In this review, summary of its phytochemistry, its uses in different medicinal systems like Ayurveda and folk system and its scientific therapeutic properties are reported.
FDA's drug regulatory pathways, its development strategies and regulatory considerations
Authors: Dhulia Iva , Patel Himani , Chauhan Narendra , Pardeshi Nidhi 
Published: July 2021

People who are interested in drug development may be aware that New Drug Applications (NDA) and Abbreviated New Drug Applications (ANDA) are 2 of the FDA's regulatory pathways for how prescription drugs can be approved and ultimately reach the market. In basic terms, NDAs are for new drugs that have not yet been approved and ANDAs are for generic products.
NDA, also called 505 (b)(1), is the format that manufacturers use to bring a formal proposal to the FDA that a new drug should be approved and made available for use by patients in the United States. Under 505(b)(1), all investigations supporting safety and effectiveness, both clinical and nonclinical, are conducted by or on behalf of the sponsor. The other pathway is termed as abbreviated because preclinical and clinical trials are not required. The abbreviated approval pathways are described in section 505(j) and 505(b)(2) of the FD&C Act and known as ANDA and Hybrid applications respectively. Hatch-Waxman amendments in 1984 provided for a suitability petition that allows the application of ANDA for a drug product that differs from the RLD in its dosage form, route of administration, strength, or active ingredient (in a product with more than one active ingredient). The differences allowed for suitability petition and 505(b)(2) application are same but ANDA filed through suitability petition can contain only those differences that do not need clinical evidence for efficacy and safety. This article identifies considerations to help potential applicants determine the appropriate submission pathway, its development strategies to support approval under those pathways.