bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poisson-geometric Analogues of Kitaev Models
Authors: Spies Alexander 
Published: March 2021

AbstractWe define Poisson-geometric analogues of Kitaev’s lattice models. They are obtained from a Kitaev model on an embedded graph $$\Gamma $$
Γ
by replacing its Hopf algebraic data with Poisson data for a Poisson-Lie group G. Each edge is assigned a copy of the Heisenberg double $${\mathcal {H}}(G)$$

H
(
G
)

. Each vertex (face) of $$\Gamma $$
Γ
defines a Poisson action of G (of $$G^*$$

G
∗

) on the product of these Heisenberg doubles. The actions for a vertex and adjacent face form a Poisson action of the double Poisson-Lie group D(G). We define Poisson counterparts of vertex and face operators and relate them via the Poisson bracket to the vector fields generating the actions of D(G). We construct an isomorphism of Poisson D(G)-spaces between this Poisson-geometrical Kitaev model and Fock and Rosly’s Poisson structure for the graph $$\Gamma $$
Γ
and the Poisson-Lie group D(G). This decouples the latter and represents it as a product of Heisenberg doubles. It also relates the Poisson-geometrical Kitaev model to the symplectic structure on the moduli space of flat D(G)-bundles on an oriented surface with boundary constructed from $$\Gamma $$
Γ
.
The cypsela (achene) of Echinacea purpurea as a diffusion unit of a community of microorganisms
Authors: Cardinale Massimiliano , Viola Marian , Miceli Elisangela , Faddetta Teresa , Puglia Anna Maria , Maggini Valentina , Tani Corrado , Firenzuoli Fabio , Schiff Silvia , Bogani Patrizia , Fani Renato , Papini Alessio 
Published: March 2021

AbstractEchinacea purpureais a plant cultivated worldwide for its pharmaceutical properties, mainly related to the stimulation of the immune system in the treatment of respiratory infections. The cypselas (fruits) ofE. purpureawere examined in order to investigate the presence, localization and potential function(s) of endophytic microorganisms. Electron and confocal microscopy observations showed that three different components of microorganisms were associated to cypselas ofE. purpurea: (i) one endocellular bacterial component in the cotyledons, enclosed within the host membrane; (ii) another more generic bacterial component adhering to the external side of the perianth; and (iii) a fungal component inside the porous layer of the perianth, the woody and porous modified residual of the flower, in the form of numerous hyphae able to cross the wall between adjacent cells. Isolated bacteria were affiliated to the generaPaenibacillus,Pantoea, andSanguibacter. Plate tests showed a general resistance to six different antibiotics and also to an antimicrobial-producingRheinheimerasp. test strain. Finally, microbiome-deprivedE. purpureaseeds showed a reduced ability to germinate, suggesting an active role of the microbiome in the plant vitality. Our results suggest that the endophytic bacterial community ofE. purpurea, previously found in roots and stem/leaves, might be already carried at the seed stage, hosted by the cotyledons. A further microbial fungal component is transported together with the seed in the perianth of the cypsela, whose remarkable structure may be considered as an adaptation for fungal transportation, and could influence the capability of the seed to germinate in the soil.Key Points•The fruit of Echinacea purpurea contains fungi not causing any damage to the plant.•The seed cotyledons contain endocellular bacteria.•Seed/fruit deprived of the microbiome showed a reduced ability to germinate.
18F FDG PET/MRI with hepatocyte-specific contrast agent for M staging of rectal cancer: a primary economic evaluation
Authors: Gassert Felix G. , Rübenthaler Johannes , Cyran Clemens C. , Rink Johann S. , Schwarze Vincent , Luitjens Johanna , Gassert Florian T. , Makowski Marcus R. , Schoenberg Stefan O. , Mayerhoefer Marius E. , Tamandl Dietmar , Froelich Matthias F. 
Published: March 2021

Abstract
Purpose
Rectal cancer is one of the most frequent causes of cancer-related morbidity and mortality in the world. Correct identification of the TNM state in primary staging of rectal cancer has critical implications on patient management. Initial evaluations revealed a high sensitivity and specificity for whole-body PET/MRI in the detection of metastases allowing for metastasis-directed therapy regimens. Nevertheless, its cost-effectiveness compared with that of standard-of-care imaging (SCI) using pelvic MRI + chest and abdominopelvic CT is yet to be investigated. Therefore, the aim of this study was to analyze the cost-effectiveness of whole-body 18F FDG PET/MRI as an alternative imaging method to standard diagnostic workup for initial staging of rectal cancer.

Methods
For estimation of quality-adjusted life years (QALYs) and lifetime costs of diagnostic modalities, a decision model including whole-body 18F FDG PET/MRI with a hepatocyte-specific contrast agent and pelvic MRI + chest and abdominopelvic CT was created based on Markov simulations. For obtaining model input parameters, review of recent literature was performed. Willingness to pay (WTP) was set to $100,000/QALY. Deterministic sensitivity analysis of diagnostic parameters and costs was applied, and probabilistic sensitivity was determined using Monte Carlo modeling.

Results
In the base-case scenario, the strategy whole-body 18F FDG PET/MRI resulted in total costs of $52,186 whereas total costs of SCI were at $51,672. Whole-body 18F FDG PET/MRI resulted in an expected effectiveness of 3.542 QALYs versus 3.535 QALYs for SCI. This resulted in an incremental cost-effectiveness ratio of $70,291 per QALY for PET/MRI. Thus, from an economic point of view, whole-body 18F FDG PET/MRI was identified as an adequate diagnostic alternative to SCI with high robustness of results to variation of input parameters.

Conclusion
Based on the results of the analysis, use of whole-body 18F FDG PET/MRI was identified as a feasible diagnostic strategy for initial staging of rectal cancer from a cost-effectiveness perspective.
The increasing potential of nuclear medicine imaging for the evaluation and reduction of normal tissue toxicity from radiation treatments
Authors: Mohan V. , Bruin N. M. , van de Kamer J. B. , Sonke J.-J. , Vogel Wouter V. 
Published: March 2021

AbstractRadiation therapy is an effective treatment modality for a variety of cancers. Despite several advances in delivery techniques, its main drawback remains the deposition of dose in normal tissues which can result in toxicity. Common practices of evaluating toxicity, using questionnaires and grading systems, provide little underlying information beyond subjective scores, and this can limit further optimization of treatment strategies. Nuclear medicine imaging techniques can be utilised to directly measure regional baseline function and function loss from internal/external radiation therapy within normal tissues in an in vivo setting with high spatial resolution. This can be correlated with dose delivered by radiotherapy techniques to establish objective dose-effect relationships, and can also be used in the treatment planning step to spare normal tissues more efficiently. Toxicity in radionuclide therapy typically occurs due to undesired off-target uptake in normal tissues. Molecular imaging using diagnostic analogues of therapeutic radionuclides can be used to test various interventional protective strategies that can potentially reduce this normal tissue uptake without compromising tumour uptake. We provide an overview of the existing literature on these applications of nuclear medicine imaging in diverse normal tissue types utilising various tracers, and discuss its future potential.
Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor
Authors: Nortunen Minna , Väkiparta Nina , Porvari Katja , Saarnio Juha , Karttunen Tuomo J , Huhta Heikki 
Published: March 2021

AbstractThe pathogenesis of gastroesophageal reflux disease (GERD) is not fully understood. It involves the activation of mucosal immune-mediated and inflammatory responses. Toll-like receptors (TLR) 2 and TLR4 are pattern-recognition receptors of the innate immune system; they recognize microbial and endogenous ligands. Farnesoid X receptor (FXR) is a bile acid receptor that regulates the inflammatory response. We aimed to evaluate TLR2, TLR4 and FXR expression patterns in GERD. We re-evaluated 84 oesophageal biopsy samples according to the global severity (GS) score, including 26 cases with histologically normal oesophagus, 28 with histologically mild oesophagitis and 30 with severe oesophagitis. We used immunohistochemistry and in situ hybridization to assess the expression patterns of TLR2, TLR4 and FXR in oesophageal squamous cells. Immunohistochemistry showed that nuclear and cytoplasmic TLR2 was expressed predominantly in the basal layer of normal oesophageal epithelium. In oesophagitis, TLR2 expression increased throughout the epithelium, and the superficial expression was significantly more intensive compared to normal epithelium, p <0.01. Nuclear and cytoplasmic TLR4 was expressed throughout the thickness of squamous epithelium, with no change in oesophagitis. FXR was expressed in the nuclei of squamous cells, and the intensity of the expression increased significantly in oesophagitis (p <0.05). FXR expression correlated with basal TLR2. In situ hybridization confirmed the immunohistochemical expression patterns of TLR2 and TLR4. In GERD, TLR2, but not TLR4, expression was upregulated which indicates that innate immunity is activated according to a specific pattern in GERD. FXR expression was increased in GERD and might have a regulatory connection to TLR2.
Late Neogene evolution of the Peruvian margin and its ecosystems: a synthesis from the Sacaco record
Authors: Ochoa Diana , Salas-Gismondi Rodolfo , DeVries Thomas J. , Baby Patrice , de Muizon Christian , Altamirano Alí , Barbosa-Espitia Angel , Foster David A. , Quispe Kelly , Cardich Jorge , Gutiérrez Dimitri , Perez Alexander , Valqui Juan , Urbina Mario , Carré Matthieu 
Published: March 2021

AbstractThe highly productive waters of the Humboldt Current System (HCS) host a particular temperate ecosystem within the tropics, whose history is still largely unknown. The Pisco Formation, deposited during Mio-Pliocene times in the Peruvian continental margin has yielded an outstanding collection of coastal-marine fossils, providing an opportunity to understand the genesis of the HCS ecosystem. We present a comprehensive review, completed with new results, that integrates geological and paleontological data from the last 10 My, especially focusing on the southern East Pisco Basin (Sacaco area). We discuss the depositional settings of the Pisco Formation and integrate new U/Pb radiometric ages into the chronostratigraphic framework of the Sacaco sub-basin. The last preserved Pisco sediments at Sacaco were deposited ~ 4.5 Ma, while the overlying Caracoles Formation accumulated from ~ 2.7 Ma onwards. We identified a Pliocene angular unconformity encompassing 1.7 My between these formations, associated with a regional phase of uplift. Local and regional paleoenvironmental indicators suggest that shallow settings influenced by the offshore upwelling of ventilated and warm waters prevailed until the early Pliocene. We present an extensive synthesis of the late Miocene–Pleistocene vertebrate fossil record, which allows for an ecological characterization of the coastal-marine communities, an assessment of biodiversity trends, and changes in coastal-marine lineages in relation to modern HCS faunas. Our synthesis shows that: (i) typical endemic coastal Pisco vertebrates persisted up to ~ 4.5 Ma, (ii) first modern HCS toothed cetaceans appear at ~ 7–6 Ma, coinciding with a decline in genus diversity, and (iii) a vertebrate community closer to the current HCS was only reached after 2.7 Ma. The genesis of the Peruvian coastal ecosystem seems to be driven by a combination of stepwise transformations of the coastal geomorphology related to local tectonic pulses and by a global cooling trend leading to the modern oceanic circulation system.
Development of a model to predict the probability of incurring a complication during spine surgery
Authors: Zehnder Pascal , Held Ulrike , Pigott Tim , Luca Andrea , Loibl Markus , Reitmeir Raluca , Fekete Tamás , Haschtmann Daniel , Mannion Anne F. 
Published: March 2021

Abstract
Purpose
Predictive models in spine surgery are of use in shared decision-making. This study sought to develop multivariable models to predict the probability of general and surgical perioperative complications of spinal surgery for lumbar degenerative diseases.

Methods
Data came from EUROSPINE's Spine Tango Registry (1.2012–12.2017). Separate prediction models were built for surgical and general complications. Potential predictors included age, gender, previous spine surgery, additional pathology, BMI, smoking status, morbidity, prophylaxis, technology used, and the modified Mirza invasiveness index score. Complete case multiple logistic regression was used. Discrimination was assessed using area under the receiver operating characteristic curve (AUC) with 95% confidence intervals (CI). Plots were used to assess the calibration of the models.

Results
Overall, 23′714/68′111 patients (54.6%) were available for complete case analysis: 763 (3.2%) had a general complication, with ASA score being strongly predictive (ASA-2 OR 1.6, 95% CI 1.20–2.12; ASA-3 OR 2.98, 95% CI 2.19–4.07; ASA-4 OR 5.62, 95% CI 3.04–10.41), while 2534 (10.7%) had a surgical complication, with previous surgery at the same level being an important predictor (OR 1.9, 95%CI 1.71–2.12). Respectively, model AUCs were 0.74 (95% CI, 0.72–0.76) and 0.64 (95% CI, 0.62–0.65), and calibration was good up to predicted probabilities of 0.30 and 0.25, respectively.

Conclusion
We developed two models to predict complications associated with spinal surgery. Surgical complications were predicted with less discriminative ability than general complications. Reoperation at the same level was strongly predictive of surgical complications and a higher ASA score, of general complications. A web-based prediction tool was developed at https://sst.webauthor.com/go/fx/run.cfm?fx=SSTCalculator.
A 3DEC Numerical Analysis of the Interaction Between an Uneven Rock Surface and Shotcrete Lining
Authors: Zhang Ping , Nordlund Ering 
Published: March 2021

AbstractRock tunnels excavated using drilling and blasting technique in jointed rock masses often have a very uneven and rough excavation surface. Experience from previous studies shows that the unevenness of a rock surface has a large impact on the support effect of shotcrete lining. However, clear conclusions regarding the effect of 2D and 3D uneven surfaces were not obtained due to limited studies in the literature. The numerical analyses reported in this paper were made to investigate the influence of the surface unevenness of a circular tunnel opening on the support effect of shotcrete using a 3D numerical code (3DEC). The models were first calibrated with the help of observations and measured data obtained from physical model tests. The influential factors were investigated further in this numerical study after calibration had been achieved. The numerical analyses show that, in general, the unevenness of a tunnel surface produces negative support effects due to stress concentrations in recesses (compressive) and at apexes (tensile) after excavation. However, shotcrete sprayed on a doubly waved uneven surface has better support effect compared to shotcrete sprayed on a simply waved tunnel surface. The development of shear strength (specifically frictional strength) on the uneven interface between the shotcrete and the rock contributes to this effect, in the condition where bonding of the shotcrete does not work effectively. The interface is a crucial element when the interaction between the rock and shotcrete is to be simulated. When an entire tunnel surface is covered by shotcrete with high modulus, more failures will occur in the shotcrete especially when rock surface is uneven. Based on the numerical model cases examined, some recommendations on how to incorporate tunnel surface conditions (2D or 3D unevenness) in the design of a shotcrete lining are given.
Changes in clinical parameters following adjunctive local sodium hypochlorite gel in minimally invasive nonsurgical therapy (MINST) of periodontal pockets: a 6-month randomized controlled clinical trial
Authors: Iorio-Siciliano Vincenzo , Ramaglia Luca , Isola Gaetano , Blasi Andrea , Salvi Giovanni E. , Sculean Anton 
Published: March 2021

Abstract
Background
The mechanical disruption and removal of the subgingival biofilm represent the most important step in the treatment of periodontitis. However, in deep periodontal pockets, mechanical removal of the subgingival biofilm is difficult and frequently incomplete. Preliminary findings indicate that the use of amino acid buffered sodium hypochlorite (NaOCl) gel may chemically destroy the bacterial biofilm and facilitate its mechanical removal.

Objectives
To clinically evaluate the efficacy of minimally invasive nonsurgical therapy (MINST) of periodontal pockets with or without local application of an amino acid buffered sodium hypochlorite (NaOCl) gel.

Materials and methods
Forty untreated patients diagnosed with severe/advanced periodontitis (i.e. stage III/IV) with a slow/moderate rate of progression (i.e. grade A/B) were randomly allocated in two treatment groups. In the test group, the periodontal pockets were treated by means of MINST and NaOCl gel application, while in the control group, treatment consisted of MINST alone. Full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS), probing depths (PD), clinical attachment levels (CAL) and gingival recessions (GR) were assessed at baseline and at 6 months following therapy. The primary outcome variable was PD reduction at sites with PD ≥ 5 mm at baseline.

Results
At 6 months, statistically significant differences between the two groups were found (p = 0.001) in terms of PD and CAL change. No statistically significant differences were found in terms of GR (p = 0.81). The number of sites with PD ≥ 5 mm and BOP (+) decreased statistically significantly (p = 0.001), i.e. from 85.3 to 2.2% in the test group and from 81.6 to 7.3% in the control group, respectively. Statistically significant differences between test and control groups were recorded at 6 months (p = 0.001). MINST + NaOCl compared to MINST alone decreased statistically significantly (p = 0.001) the probability of residual PDs ≥ 5 mm with BOP− (14.5% vs 18.3%) and BOP+ (2.2% vs. 7.2%).

Conclusions
Within their limits, the present results indicate that (a) the use of MINST may represent a clinically valuable approach for nonsurgical therapy and (b) the application of NaOCl gel in conjunction with MINST may additionally improve the clinical outcomes compared to the use of MINST alone.

Clinical relevance
In patients with untreated periodontitis, treatment of deep pockets by means of MINST in conjunction with a NaOCl gel may represent a valuable approach to additionally improve the clinical outcomes obtained with MINST alone
The cost-effectiveness of treatments for attention deficit-hyperactivity disorder and autism spectrum disorder in children and adolescents: a systematic review
Authors: Sampaio Filipa , Feldman Inna , Lavelle Tara A. , Skokauskas Norbert 
Published: March 2021

AbstractEconomic evaluations can help decision makers identify what services for children with neurodevelopmental disorders provide best value-for-money. The aim of this paper is to review the best available economic evidence to support decision making for attention deficit-hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children and adolescents. We conducted a systematic review of economic evaluations of ADHD and ASD interventions including studies published 2010–2020, identified through Econlit, Medline, PsychINFO, and ERIC databases. Only full economic evaluations comparing two or more options, considering both costs and consequences were included. The quality of the studies was assessed using the Drummond checklist. We identified ten studies of moderate-to-good quality on the cost-effectiveness of treatments for ADHD and two studies of good quality of interventions for ASD. The majority of ADHD studies evaluated pharmacotherapy (n = 8), and two investigated the economic value of psychosocial/behavioral interventions. Both economic evaluations for ASD investigated early and communication interventions. Included studies support the cost-effectiveness of behavioral parenting interventions for younger children with ADHD. Among pharmacotherapies for ADHD, different combinations of stimulant/non-stimulant medications for children were cost-effective at willingness-to-pay thresholds reported in the original papers. Early intervention for children with suspected ASD was cost-effective, but communication-focused therapy for preschool children with ASD was not. Prioritizing more studies in this area would allow decision makers to promote cost-effective and clinically effective interventions for this target group.
Using a new video rating tool to crowd-source analysis of behavioural reaction to stimuli
Authors: Root-Gutteridge Holly , Brown Louise P. , Forman Jemma , Korzeniowska Anna T. , Simner Julia , Reby David 
Published: March 2021

AbstractQuantifying the intensity of animals’ reaction to stimuli is notoriously difficult as classic unidimensional measures of responses such as latency or duration of looking can fail to capture the overall strength of behavioural responses. More holistic rating can be useful but have the inherent risks of subjective bias and lack of repeatability. Here, we explored whether crowdsourcing could be used to efficiently and reliably overcome these potential flaws. A total of 396 participants watched online videos of dogs reacting to auditory stimuli and provided 23,248 ratings of the strength of the dogs’ responses from zero (default) to 100 using an online survey form. We found that raters achieved very high inter-rater reliability across multiple datasets (although their responses were affected by their sex, age, and attitude towards animals) and that as few as 10 raters could be used to achieve a reliable result. A linear mixed model applied to PCA components of behaviours discovered that the dogs’ facial expressions and head orientation influenced the strength of behaviour ratings the most. Further linear mixed models showed that that strength of behaviour ratings was moderately correlated to the duration of dogs’ reactions but not to dogs’ reaction latency (from the stimulus onset). This suggests that observers’ ratings captured consistent dimensions of animals’ responses that are not fully represented by more classic unidimensional metrics. Finally, we report that overall participants strongly enjoyed the experience. Thus, we suggest that using crowdsourcing can offer a useful, repeatable tool to assess behavioural intensity in experimental or observational studies where unidimensional coding may miss nuance, or where coding multiple dimensions may be too time-consuming.