bluuebunny/crossref_metadata_2025_split huggingface dataset:
WAYANG GODHONG SEBAGAI MEDIA EDUKASI CINTA BUDAYA DAN ALAM SEJAK USIA DINI
Authors: Purwanto Agus , Octavia Ercilia Rini , Adi Sigit Purnomo 
Published: March 2021

AbstrakSeiring dengan perkembangan zaman, pertunjukan wayang berfungsi menjadi media pembelajaran. Demikian halnya dengan Wayang Godhong. Wayang kontemporer yang berasal dari godhong (daun) jati, cengkeh, dan kopi ini mencoba menjadikan pertunjukan wayangnya sebagai media edukasi cinta budaya dan alam sejak usia dini di Kabupaten Magelang. Artikel yang disusun melalui metode penelitian kualitatif deskriptif ini, berhasil menemukan visualisasi figur/karakter Wayang Godhong yang representatif untuk anak usia dini dengan pendekatan visual yang ramah dan lucu. Kemudian proses penyampaian dalang Wayang Godhong saat pentas yang harus menggunakan mimik jelas (karena dalang di depan anak-anak, tidak di balik layar), sehingga bahasa yang digunakan pun harus bahasa yang mudah dipahami anak-anak dengan penyampaian humorisme. Setelah melihat pementasan, anak-anak pun berkeinginan melakukan seperti yang dipesankan dalam pementasan yakni menanam pohon sebagai upaya melestarikan alam ini serta menjadi suka/cinta akan wayang. Dengan demikian Wayang Godhong dianggap mampu menjadi media edukasi cinta wayang sebagai hasil dari budaya Indonesia dan cinta alam dengan menanam/merawat pohon sejak usia dini. Kata Kunci: budaya dan alam, media edukasi, anak usia dini, Wayang Godhong AbstractAlong with the times, puppet shows function as learning media. Like wise with Wayang Godhong. Wayang Godhong, a form of contemporary wayang made from leaves of teak, cloves, and coffee, attempts to become a medium for children to foster a sense of love for nature and culture, especially in the Magelang Regency. This article, compiled through descriptive qualitative research methods, has succeeded in finding the visualization of the representative Wayang Godhong figures/characters for early childhood with a friendly and funny visual approach. The performance process of storytelling by the puppeteer must be used a clear facial expression (because the puppeteer stays in front of the children, not behind the scenes), the language must be easy to understand by the children by conveying humorism. After seeing the performance, the children wanted to do as instructed in the wayang performance, such as planting trees as an effort to preserve nature and became interested in wayang. Thereby, Wayang Godhong is considered capable of being a love for wayang educational media as a result of Indonesian culture and love for nature by planting/caring for trees from an early age. Keywords: children, culture and nature, education media, Godhong puppet
Factors Associated With the Microbiome in Moderate–Late Preterm Babies: A Cohort Study From the DIAMOND Randomized Controlled Trial
Authors: Chong Clara Yieh Lin , Vatanen Tommi , Alexander Tanith , Bloomfield Frank H. , O’Sullivan Justin M. 
Published: March 2021

The gut microbiota of preterm infants is affected by perinatal factors and, in turn, may impact upon infant health. In this study, we collected fecal samples at Day-10 (D10) and 4-months corrected-age (4M) from 227 moderate–late preterm (MLPT) babies enrolled in a randomized controlled trial of nutritional management. A total of 320 samples underwent 16S amplicon sequencing, and shotgun metagenomic sequencing was performed on 94 samples from the 4M time point. The microbiome of babies whose families lived in lower socioeconomic status (SES) areas exhibited a significantly higher microbial alpha diversity at D10 (Wilcoxon test, p = 0.021), greater abundance of Bifidobacterium (linear model, q = 0.020) at D10 and Megasphaera (q = 0.031) at 4M. Hospital of birth explained 5.2% of the observed variance in 4M samples (PERMANOVA, p = 0.038), with Staphylococcus aureus more abundant in fecal samples from babies born in Middlemore hospital (linear model, q = 0.016). Maternal antibiotic (Wilcoxon test, p = 0.013) and probiotic (p = 0.04) usage within the four-week period before sample collection was associated with a reduction in the alpha diversity of D10 samples. Infant probiotic intake explained 2.1% (PERMANOVA, p = 0.021) of the variance in the D10 microbial profile with increased Lactobacillus (linear model, q = 1.1 × 10−10) levels. At 4M, the microbiome of infants who were breastmilk fed had reduced alpha diversity when compared to non-breastmilk fed infants (Wilcoxon test, p &lt; 0.05). Although causality cannot be inferred within our study, we conclude that in MLPT babies, maternal socioeconomic factors, as well as the perinatal medical environment and nutrition impact on the development of the newborn microbiome.
Sex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy
Authors: Schuldt Maike , Dorsch Larissa M. , Knol Jaco C. , Pham Thang V. , Schelfhorst Tim , Piersma Sander R. , dos Remedios Cris , Michels Michelle , Jimenez Connie R. , Kuster Diederik W. D. , van der Velden Jolanda 
Published: March 2021

Background: Sex-differences in clinical presentation contribute to the phenotypic heterogeneity of hypertrophic cardiomyopathy (HCM) patients. While disease prevalence is higher in men, women present with more severe diastolic dysfunction and worse survival. Until today, little is known about the cellular differences underlying sex-differences in clinical presentation.Methods: To define sex-differences at the protein level, we performed a proteomic analysis in cardiac tissue obtained during myectomy surgery to relieve left ventricular outflow tract obstruction of age-matched female and male HCM patients harboring a sarcomere mutation (n = 13 in both groups). Furthermore, these samples were compared to 8 non-failing controls. Women presented with more severe diastolic dysfunction.Results: Out of 2099 quantified proteins, direct comparison of male, and female HCM samples revealed only 46 significantly differentially expressed proteins. Increased levels of tubulin and heat shock proteins were observed in female compared to male HCM patients. Western blot analyses confirmed higher levels of tubulin in female HCM samples. In addition, proteins involved in carbohydrate metabolism were significantly lower in female compared to male samples. Furthermore, we found lower levels of translational proteins specifically in male HCM samples. The disease-specificity of these changes were confirmed by a second analysis in which we compared female and male samples separately to non-failing control samples. Transcription factor analysis showed that sex hormone-dependent transcription factors may contribute to differential protein expression, but do not explain the majority of protein changes observed between male and female HCM samples.Conclusion: In conclusion, based on our proteomics analyses we propose that increased levels of tubulin partly underlie more severe diastolic dysfunction in women compared to men. Since heat shock proteins have cardioprotective effects, elevated levels of heat shock proteins in females may contribute to later disease onset in woman, while reduced protein turnover in men may lead to the accumulation of damaged proteins which in turn affects proper cellular function.
The Effectiveness of Image Augmentation in Deep Learning Networks for Detecting COVID-19: A Geometric Transformation Perspective
Authors: Elgendi Mohamed , Nasir Muhammad Umer , Tang Qunfeng , Smith David , Grenier John-Paul , Batte Catherine , Spieler Bradley , Leslie William Donald , Menon Carlo , Fletcher Richard Ribbon , Howard Newton , Ward Rabab , Parker William , Nicolaou Savvas 
Published: March 2021

Chest X-ray imaging technology used for the early detection and screening of COVID-19 pneumonia is both accessible worldwide and affordable compared to other non-invasive technologies. Additionally, deep learning methods have recently shown remarkable results in detecting COVID-19 on chest X-rays, making it a promising screening technology for COVID-19. Deep learning relies on a large amount of data to avoid overfitting. While overfitting can result in perfect modeling on the original training dataset, on a new testing dataset it can fail to achieve high accuracy. In the image processing field, an image augmentation step (i.e., adding more training data) is often used to reduce overfitting on the training dataset, and improve prediction accuracy on the testing dataset. In this paper, we examined the impact of geometric augmentations as implemented in several recent publications for detecting COVID-19. We compared the performance of 17 deep learning algorithms with and without different geometric augmentations. We empirically examined the influence of augmentation with respect to detection accuracy, dataset diversity, augmentation methodology, and network size. Contrary to expectation, our results show that the removal of recently used geometrical augmentation steps actually improved the Matthews correlation coefficient (MCC) of 17 models. The MCC without augmentation (MCC = 0.51) outperformed four recent geometrical augmentations (MCC = 0.47 for Data Augmentation 1, MCC = 0.44 for Data Augmentation 2, MCC = 0.48 for Data Augmentation 3, and MCC = 0.49 for Data Augmentation 4). When we retrained a recently published deep learning without augmentation on the same dataset, the detection accuracy significantly increased, with aχMcNemar′s statistic2=163.2and ap-value of 2.23 × 10−37. This is an interesting finding that may improve current deep learning algorithms using geometrical augmentations for detecting COVID-19. We also provide clinical perspectives on geometric augmentation to consider regarding the development of a robust COVID-19 X-ray-based detector.
Risk of Liver Injury Associated with Intravenous Lipid Emulsions: A Prescription Sequence Symmetry Analysis
Authors: Li Xiao-xiao , Cheng Yin-chu , Zhai Suo-di , Yao Peng , Zhan Si-yan , Shi Lu-wen 
Published: March 2021

Aims: To determine the risk of liver injury associated with the use of different intravenous lipid emulsions (LEs) in large populations in a real-world setting in China.Methods: A prescription sequence symmetry analysis was performed using data from 2015 Chinese Basic Health Insurance for Urban Employees. Patients newly prescribed both intravenous LEs and hepatic protectors within time windows of 7, 14, 28, 42, and 60 days of each other were included. The washout period was set to one month according to the waiting-time distribution. After adjusting prescribing time trends, we quantify the deviation from symmetry of patients initiating LEs first and those initiating hepatic protectors first, by calculating adjusted sequence ratios (ASRs) and relevant 95% confidence intervals. Analyses were further stratified by age, gender, and different generations of LEs developed.Results: In total, 416, 997, 1,697, 2,072, and 2,342 patients filled their first prescriptions with both drugs within 7, 14, 28, 42, and 60 days, respectively. Significantly increased risks of liver injury were found across all time windows, and the strongest effect was observed in the first 2 weeks [ASR 6.97 (5.77–8.42) ∼ 7.87 (6.04–10.61)] in overall patients. In subgroup analyses, female gender, age more than 60 years, and soybean oil-based and alternative-LEs showed higher ASRs in almost all time windows. Specially, a lower risk for liver injury was observed in the first 14 days following FO-LEs administration (ASR, 3.42; 95% CI, 0.81–14.47), but the risk started to rise in longer time windows.Conclusion: A strong association was found between LEs use and liver injury through prescription sequence symmetry analysis in a real-world setting, which aligns with trial evidence and clinical experience. Differences revealed in the risks of liver injury among various LEs need further evaluation.
Effects of Small-Sided Games vs. Running-Based High-Intensity Interval Training on Physical Performance in Soccer Players: A Meta-Analytical Comparison
Authors: Clemente Filipe Manuel , Ramirez-Campillo Rodrigo , Afonso José , Sarmento Hugo 
Published: March 2021

Objectives: This systematic review with meta-analysis (SRMA) was conducted to compare the effects of SSG-based interventions vs. running-based HIIT interventions on soccer players' sprinting time (ST), vertical height jump (VJH), and change of direction time (CODt).Data Sources: The data sources utilized were Web of Science, Scopus, SPORTDiscus, and PubMed.Results: An electronic search yielded 650 articles, six of which were included in the present study. Between-group analysis found a significant favoring effect of HIIT-based over SSG-based training interventions for the improvement of linear sprinting time (ES = 0.42; p = 0.012). A within-group analysis revealed a significant favoring effect of HIIT-based training interventions for improving linear sprinting time (ES = 0.42; p = 0.008) and CODt (ES = 1.04; p = 0.005) despite a non-significant effect on VJH (ES = 0.47; p = 0.22).Conclusions: The meta-analytical comparison revealed favoring the effect of running-based HIIT over SSG-based interventions in sprinting performance, although no significant differences were observed for jumping and CODt performance. The findings suggest that SSG-based programs should be supplemented by other training methods that benefit determinant capacities in soccer players.
The Clinicopathological Significance of YAP/TAZ Expression in Hepatocellular Carcinoma with Relation to Hypoxia and Stemness
Authors: Park Hyunjin , Lee Yangkyu , Lee Kiryang , Lee Hyejung , Yoo Jeong Eun , Ahn Soomin , Park Young Nyun , Kim Haeryoung 
Published: March 2021

Background/Aims: Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) activation has been implicated in hepatocarcinogenesis and hepatic progenitor cell differentiation, and hypoxia has been shown to induce nuclear translocation of YAP in cancer cells. Here, we aimed to investigate the relationship between hypoxia, YAP and TAZ expression and stemness-related marker expression in human hepatocellular carcinomas (HCCs) and its clinical implications.Methods: Immunohistochemical stains were performed on tissue microarrays from 305 surgically resected HCCs, and the expression status of YAP and TAZ were correlated with CAIX, stemness markers (K19, EpCAM) and epithelial-mesenchymal transition (EMT)-related markers (uPAR, ezrin). The clinicopathological significance of YAP/TAZ expression was analyzed with relation to CAIX expression status.Results: YAP and TAZ expression were seen in 13.4 and 4.3% of HCCs, respectively. YAP/TAZ-positive HCCs frequently demonstrated higher serum AFP levels, microvascular invasion, advanced tumor stage, increased proliferative activity and expression of stemness- and EMT-related markers, CAIX, p53 and Smad2/3 (p &lt; 0.05, all). Interestingly, YAP/TAZ-positivity was associated with microvascular invasion, higher serum AFP levels, stemness and EMT-related marker expression only in tumors expressing CAIX (p &lt; 0.05, all), while these associations were not seen in CAIX-negative HCCs.Conclusions: YAP/TAZ expression is associated with vascular invasion, stemness and EMT in HCCs with hypoxia marker expression. The effect of Hippo signaling pathway deregulation in HCC may depend on the presence or absence of a hypoxic microenvironment, and hypoxia marker expression status should be taken into account when considering the use of YAP/TAZ as markers of aggressive biologic behavior in HCC.
Modelling of Conditional Scalar Dissipation Rate in Turbulent Premixed Combustion
Authors: Amzin Shokri , Domagała Mariusz 
Published: March 2021

In turbulent premixed flames, for the mixing at a molecular level of reactants and products on the flame surface, it is crucial to sustain the combustion. This mixing phenomenon is featured by the scalar dissipation rate, which may be broadly defined as the rate of micro-mixing at small scales. This term, which appears in many turbulent combustion methods, includes the Conditional Moment Closure (CMC) and the Probability Density Function (PDF), requires an accurate model. In this study, a mathematical closure for the conditional mean scalar dissipation rate, <Nc|ζ>, in Reynolds, Averaged Navier–Stokes (RANS) context is proposed and tested against two different Direct Numerical Simulation (DNS) databases having different thermochemical and turbulence conditions. These databases consist of lean turbulent premixed V-flames of the CH4-air mixture and stoichiometric turbulent premixed flames of H2-air. The mathematical model has successfully predicted the peak and the typical profile of <Nc|ζ> with the sample space ζ and its prediction was consistent with an earlier study.
UJI KADAR AIR, ABU DAN KARBOHIDRAT PADA SAGU IKAN CAKALANG DI KABUPATEN PULAU MOROTAI
Authors: Sofiati Titien , Asyari Asyari , Sidin Jana 
Published: March 2021

Sagu ikan merupakan hasil diversifikasi produk perikanan yang menggabungkan panganan tradisional dengan salah satu sumberdaya ikan lokal. Penambahan ikan pada bahan utama sagu yakni ubi kayu diharapkan dapat meningkatkan kandungan gizi sehingga dapat menjadi suatu produk olahan yang bernilai ekonomis. Tujuan penelitian adalah untuk mengetahui kandungan air, abu dan karbohidrat pada sagu ikan. Manfaat yang diharapkan dari penelitian ini adalah (1) memberikan informasi bagi masyarakat tentang pengolahan sagu yang ditambahkan daging ikan cakalang memiliki nilai gizi yang cukup lengkap, (2) diversifikasi dan pengembangan produk perikanan yang baru yang memiliki nilai ekonomis penting untuk masyarakat luas, baik instansi pemerintah maupun swasta yang berkecimpung dalam usaha pembuatan sagu ikan. Penelitian dilaksanakan di Laboratorium Lingkungan Universitas Khairun Ternate. Hasil uji laboratorium menunjukan bahwa penambahan ikan cakalang pada sagu menurunkan kadar air 11,21% menjadi 10,66%, karbohidrat 70,40% menjadi 60,43%. Namun, menaikan kadar abu yang terkandung pada sagu ikan 0,98% menjadi 1,80%.
Use of doping to achieve low contact resistance in bottom-gate top-contact type organic transistor with liquid-crystalline organic semiconductor, Ph-BTBT-10
Authors: Takamaru Shun , Hanna Jun-ichi , Iino Hiroaki 
Published: March 2021

Abstract
We have investigated the characteristics of bottom-gate and top-contact type field effect transistors fabricated with polycrystalline thin films of a liquid-crystalline organic semiconductor, 2-decyl-7-phenyl-benzothienobenzothiophene (Ph-BTBT-10), with a p-type dopant, tetrafluoro-tetracyano-quinodimethane (F4-TCNQ). We found that the contact resistance between the semiconductor and electrode was reduced from 3.0 kΩ cm to 1.2 kΩ cm by contact doping with F4-TCNQ, and to 0.9 kΩcm by subsequent thermal annealing of the films, in which the F4-TCNQ dopant diffused from the surface to the interior of the Ph-BTBT-10 thin film. In addition, we found that contact-doped and thermally annealed devices showed higher mobility and smaller threshold voltage in short-channel devices compared to pristine devices. We conclude that thermal diffusion of dopants to improve FET performance is an important technique.
Alimentação e obesidade de crianças na fase pré-escolar: significados atribuí­dos pelos pais
Authors: Custódio Cardoso de Faria Glaubert , Alves Azevedo Sarah , Nunes Andrade Silmara , de Oliveira Flávia 
Published: March 2021

Objetivos: Avaliar a percepção dos pais de crianças com sobrepeso ou obesidade, em relação í qualidade da alimentação dos seus filhos, na fase pré-escolar. Método: Estudo descritivo e qualitativo, realizado por meio de entrevistas semi-estruturadas, com pais de crianças com sobrepeso ou obesas matriculadas em um Centro Municipal de Educação Infantil (CEMEI) e cadastrado nas Estratégias de Saúde da Famí­lia (ESF"™s) do municí­pio de Divinópolis-MG. Resultados: Em relação í caracterização dos pais, todos eram do sexo feminino. A faixa etária alternou entre 22 a 45 anos. A partir da análise dos dados, as categorias elencadas foram: Alimentação inadequada; Tecnologia e sedentarismo; A subestimação do sobre peso; Prevenção e tratamento da obesidade infantil nas ESF. Conclusão: Identificou-se a necessidade de um melhor preparo por parte dos profissionais de saúde em relação a correta nutrição das crianças e também um envolvimento entre esses profissionais, os pais e a escola.
THE EFFECT OF USING COMPUTER ASSISTED LANGUAGE LEARNING (CALL) METHOD ON STUDENTS’ LISTENING SKILL AT THE SEVENTH GRADE STUDENTS OF SMP NEGERI 3 STABAT
Authors: Umara Ummi , Lestari Ika 
Published: March 2021

Applying an appropriate teaching method plays an important role in the teaching or learning process including teaching listening as a skill. The listening skill is one of the four most important and difficult skill to be taught in English. Students are facing a difficulty either in understanding native speaker or in producing native-like English (accent/pronunciation). They are also unprepared to function in the new word. And then, in most class students are unmotivated and act as passive listeners. This study aimed to find out whether using computer assisted language learning (CALL) method affect listening skill. In this study, using computer assisted language learning (call) method as the independent variable (X) and students’ listening skill as the dependent variable (Y), with the hypothesis: using computer assisted language learning (CALL) method affects on students’ listening skill of seventh year students of SMP NEGERI 3 STABAT at academic year 2018/2019. The population of this study was seventh year students of SMP NEGERI 3 STABAT at academic year 2018/2019, which consisted of 185 students. The sample was taken by using random sampling technique, the total sample was 60 students. Then, the sample was divided into two groups, the group taught by using computer assisted language learning (CALL) was as the experimental group and the group taught without computer assisted language learning (CALL) was as the control group. The writer used test as the instrument of collecting data. The data was analyzed by using t-test formula. Based on the data analysis, it was found that the value of t-observed (to) was higher than the value of t-table, (tobserved = 8,39 > ttable = 1.67). Therefore, the hypothesis proposed by the writer was accepted. In the other words, using computer assisted language learning (CALL) affects listening skill of seventh year students of SMP NEGERI 3 STABAT at academic year 2018/2019.