bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐affinity immunoglobulin gamma Fc region receptor III‐B (FcγRIIIB, CD16B) deficiency in patients with blood and immune system disorders
Authors: Minguela Alfredo , Salido Eduardo J. , Soto‐Ramírez María F. , Olga Montes‐Ares , Leal Juan D. , García‐Garay María C. , Periago Adela , Berenguer Mercedes , Blanque Miguel , Campillo José A. 
Published: September 2021

SummaryLow‐affinity immunoglobulin gamma Fc region receptor III‐B (FcγRIIIB) deficiency is present in ˜0·05% of the general population. Among our patients, FcγRIIIB deficiency was less frequent in those with immune‐system disorders (one of 1815 patients, 0·05%) than in those with blood disorders (nine of 2147 patients, 0·42%, P = 0·023): mainly primary immune thrombocytopenia (4·34%), therapy related myeloid neoplasms (1·16%) and myelodysplastic syndrome with excess blasts (1·28%). Four of the nine (44·4%) patients with blood disorders were diagnosed with or quickly evolved to acute myeloid leukaemia (AML), suggesting that FcγRIIIB deficiency could be an adverse prognostic factor for progression to AML that should be confirmed in large multicentre studies.
In vitro and in vivo accuracy of full‐arch digital implant impressions
Authors: Rutkunas Vygandas , Gedrimiene Agne , Akulauskas Mykolas , Fehmer Vincent , Sailer Irena , Jegelevicius Darius 
Published: September 2021

AbstractObjectivesThe main objective of the study was to compare the accuracy of full‐arch digital implant impressions for fixed dental prosthesis under in vitro and in vivo conditions.Materials and MethodsEight patients (five women and three men) with at least one edentulous arch and with 4–6 osseointegrated implants participated in this study. For each edentulous arch (n = 10), experimental screw‐retained titanium bar with attached four scan bodies was fabricated. The bar containing four scan bodies was screw‐retained intraorally on implants and scanned with Trios 3 intraoral scanner eight times (IOS group, in vivo). Then, the bar was attached to the master cast and scanned eight times again with the same intraoral scanner (MIOS group, in vitro). Finally, the bar with scan bodies was scanned 8 times with a laboratory scanner (reference). Precision and trueness were calculated for 3 distances and 3 angles between the scan bodies (1–2, 1–3, and 1–4) in IOS and MIOS groups.ResultsPrecision and trueness for the largest distance (1–4) were found to be 44 ± 18 µm and 32 ± 19 µm for the IOS group and 31 ± 16 µm and 30 ± 14 µm for MIOS group, respectively. Precision and trueness for the angle between the most distant scan bodies (1–4) were 0.22 ± 0.14° and 0.18 ± 0.10° for the IOS group and 0.16 ± 0.11° and 0.07 ± 0.05° for MIOS group, respectively.ConclusionsIntraoral conditions moderately affected the precision and trueness of Trios 3 (3Shape) intraoral scanner. Results of in vitro accuracy studies cannot be directly transferred to the clinical field.
Males with abdominal aortic aneurysm have reduced left ventricular systolic and diastolic function
Authors: Åström Malm Ida , De Basso Rachel , Engvall Jan , Blomstrand Peter 
Published: September 2021

AbstractBackgroundAbdominal aortic aneurysm (AAA) increases the risk of chronic heart failure and other major cardiovascular events. Knowledge about left ventricular function in patients with AAA is lacking. This echocardiographic study aimed to investigate whether AAA is associated with left ventricular systolic and diastolic dysfunction.MethodsEchocardiography was performed in 307 males (199 AAA and 108 controls) recruited from a regional ultrasound surveillance programme of known AAA, or from an ongoing ultrasound screening programme, during 2011–2016.ResultsSubjects with AAA had thicker septal and posterior walls and a reduced left ventricular function compared to controls. Left ventricular ejection fraction (AAA 55 ± 8%, controls 57 ± 7%) and global longitudinal strain (AAA 19 ± 3%, controls 20 ± 3%) were lower in the group with AAA (both p < 0·05). Moreover, decreased mitral annular plane systolic excursion (12 ± 2 mm versus 13 ± 2 mm) and higher E/e' (13 ± 5 versus 11 ± 4) were observed in subjects with AAA (both p < 0·05). The aortic sinus (38 ± 4 mm versus 35 ± 2 mm) and ascending aorta (36 ± 4 mm versus 34 ± 5 mm) were also wider in the AAA group compared to controls (both p < 0·01).ConclusionAAAs are associated with reduced left ventricular systolic and diastolic function in males. The larger diameter of the aortic sinus and ascending aorta among AAA patients suggests that AAA is a general aortic disease.
The lipid‐binding START domain regulates the dimerization of ATML1 via modulating the ZIP motif activity in Arabidopsis thaliana
Authors: Nagata Kenji , Abe Mitsutomo 
Published: September 2021

AbstractIn Arabidopsis thaliana, the epidermis is the outermost cell layer composed of many specialized types of epidermal cells, such as pavement cells, trichomes, and guard cells. The homeodomain‐leucine zipper (HD‐ZIP) class Ⅳ transcription factors (TFs), which are unique to the plant kingdom, have been recognized as key regulators of epidermis development. Unlike animal HD proteins, which can bind to DNA as monomers, plant HD‐ZIP class Ⅳ TFs bind to DNA as dimers, although little is known about the regulation of their dimerization process. Here, we show that the homodimerization of ARABIDOPSIS THALIANA MERISTEM LAYER 1 (ATML1) — HD‐ZIP class Ⅳ TF that is required for protoderm development — is regulated by the lipid‐binding steroidogenic acute regulatory protein‐related lipid transfer (START) domain. We found that ATML1 forms homodimer through interaction via its ZIP motif in yeast and plant cells, although the interaction is abolished by generating a mutation into the lipid‐binding START domain to disrupt the lipid‐binding ability. These results suggest that lipidic ligands function as key regulators of protoderm development via modulating the dimerization of ATML1.
Prognostic value of haemoglobin drop in patients with acute coronary syndromes
Authors: Ndrepepa Gjin , Neumann Franz‐Josef , Menichelli Maurizio , Holdenrieder Stefan , Richardt Gert , Mayer Katharina , Cassese Salvatore , Xhepa Erion , Kufner Sebastian , Wiebe Jens , Joner Michael , Kessler Thorsten , Laugwitz Karl Ludwig , Schunkert Heribert , Kastrati Adnan 
Published: September 2021

AbstractBackgroundThe prognostic value of in‐hospital haemoglobin drop in patients with acute coronary syndrome (ACS) undergoing invasive therapy remains insufficiently investigated.Materials and MethodsThis observational study included 3838 patients with ACS with admission and in‐hospital nadir haemoglobin values available. Haemoglobin drop was defined as a positive difference between admission and nadir haemoglobin values. The primary endpoint was one‐year all‐cause mortality.ResultsIn‐hospital haemoglobin drop occurred in 3142 patients (82%). Patients were categorized into 4 groups: no haemoglobin drop (n = 696 patients), <3 g/dl haemoglobin drop (n = 2703 patients), 3 to <5 g/dl haemoglobin drop (n = 344 patients) and ≥5 g/dl haemoglobin drop (n = 95 patients). The primary endpoint occurred in 156 patients: 17 patients (2.5%) in the group with no haemoglobin drop, 81 patients (3.0%) in the group with <3g/dl haemoglobin drop, 37 patients (10.9%) in the group with 3 to <5 g/dl haemoglobin drop and 21 patients (22.2%) in the group with ≥5 g/dl haemoglobin (adjusted hazard ratio [HR] = 1.30, 95% confidence interval 1.17 to 1.45; p < .001 for one g/dl haemoglobin drop). The association of haemoglobin drop with one‐year mortality remained significant after exclusion of patients with in‐hospital overt bleeding (adjusted HR = 1.27 [1.11–1.46]; p < .001 for one g/dl haemoglobin drop). The lowest haemoglobin drop associated with mortality was 1.23 g/dl in all patients (HR = 1.03 [1.02–1.04]) and 1.13 g/dl in patients without overt bleeding (HR = 1.03 [1.01–1.04]).ConclusionsIn patients with ACS, in‐hospital haemoglobin drop was associated with higher risk of one‐year mortality even in the absence of overt bleeding.
How are you coping with the COVID‐19 pandemic? Survey of undergraduate dental students’ well‐being during an unexpected global event
Authors: Poma Malosi , Al Amri Firas , Tawse‐Smith Andrew , Ma Sunyoung 
Published: September 2021

AbstractBackgroundCOVID‐19 pandemic has led to major life changes including suspension of dental education programmes worldwide. The impact of this unexpected disruption in clinical teaching needs to be assessed.AimThe aim of this study was to evaluate the impact of the COVID‐19 restriction measures on the undergraduate dental students’ perception regarding their physical, mental and social well‐being as well as financial stress and anxiety for their future careers.Materials and methodsAn electronic questionnaire (Qualtrics, Provo, Utah, USA) with main themes (general well‐being, academic stressors, financial implications and dental career concerns) related to the COVID‐19 lockdown was sent to the undergraduate dental students at the University Of Otago, New Zealand. Participants were asked to rank their answers according to a 5‐level Likert scale (strongly disagreed‐strongly agreed). Other questions included demographic, fee‐paying status and living situation.ResultsThere were 301 out of 376 students who responded to the survey. Generally, the students perceived that the COVID‐19 restrictions affected their behavioural and social well‐being (3.20 ± 0.75) and less impact on their physical (2.75 ± 0.82) and psychological (2.79 ± 0.62) well‐being. Students were significantly worried about their academic work and future careers (3.41 ± 1.20), but less concerned with their financial situation (2.74 ± 1.14).ConclusionsThe study provides valuable information on the impact of COVID‐19 pandemic on undergraduate dental students, and areas that the University should consider when providing support to the affected students. It is important that the University is proactive and prepared to deal with future pandemics effectively and efficiently.
Effect of training on time efficiency and marginal adaptation of computer‐aided design/computer‐aided manufacturing crowns among dental students
Authors: Tan Ying Yin , Ho Ting Khee , Goo Chui Ling 
Published: September 2021

AbstractIntroductionThe computer‐aided design/computer‐aided manufacturing (CAD/CAM) technology has revolutionised dentistry at present. An operator's skills can affect the overall clinical duration and marginal accuracy of the prosthesis fabricated through this workflow. The aim of this study was to assess the effect of CAD/CAM hands‐on training compared with that of a self‐instructional video on the performance of dental students in digital impression and fabrication of a CAD/CAM crown.MethodsIn this cross‐sectional study, 30 undergraduate dental students were shown a CEREC demonstration video. Each operator then captured a digital impression using the intra‐oral scanner, and a crown was subsequently milled. All participants underwent a training course before repeating the process. Marginal discrepancy for each crown on its abutment tooth was measured before and after training using a stereomicroscope and was evaluated using Wilcoxon signed rank test. The duration taken for the process was recorded before and after training and evaluated using paired t‐test.ResultsThe overall mean ±standard deviation marginal adaptation for the CEREC crowns was 78.15 ± 42.83 μm before training and 52.41 ± 17.12 μm after training. The Wilcoxon signed rank test found significant difference (p < .05) in terms of marginal adaptation of crowns fabricated before and after training. Paired t‐tests showed that the time efficiency after training significantly improved compared with that before training.ConclusionsTraining with guided feedback is crucial to improve the time efficiency of making a digital impression and marginal adaptation of fixed prosthesis using the CAD/CAM technology.
Ageing‐related changes in nap neuroscillatory activity are mediated and moderated by grey matter volume
Authors: Fitzroy Ahren B. , Kainec Kyle A. , Spencer Rebecca M. C. 
Published: September 2021

AbstractAgeing‐related changes in grey matter result in changes in the intensity and topography of sleep neural activity. However, it is unclear whether these findings can be explained by ageing‐related differences in sleep pressure or circadian influence. The current study used high‐density electroencephalography to assess how grey matter volume differences between young and older adults mediate and moderate neuroscillatory activity differences during a midday nap following a motor sequencing task. Delta, theta, and sigma amplitude were reduced in older relative to young adults, especially over frontocentral scalp, leading to increases in relative delta frontality and relative sigma lateral centroposteriority. Delta reductions in older adults were mediated by grey matter loss in frontal medial cortex, primary motor cortex, thalamus, caudate, putamen, and pallidum, and were moderated by putamen grey matter volume. Theta reductions were mediated by grey matter loss in primary motor cortex, thalamus, and caudate, and were moderated by putamen and pallidum grey matter volume. Sigma changes were moderated by putamen and pallidum grey matter volume. Moderation results suggested that across frequencies, young adults with more grey matter had increased activity, whereas older adults with more grey matter had unchanged or decreased activity. These results provide a critical extension of previous findings from overnight sleep in a midday nap, indicating that they are not driven by sleep pressure or circadian confounds. Moreover, these results suggest brain regions associated with motor sequence learning contribute to sleep neural activity following a motor sequencing task.
Iris Murdoch, privacy, and the limits of moral testimony
Authors: Mason Cathy 
Published: September 2021

AbstractRecent discussions of moral testimony have focused on the acceptability of forming beliefs on the basis of moral testimony, but there has been little acknowledgement of the limits to testimony's capacity to convey moral knowledge. In this paper I outline one such limit, drawing on Iris Murdoch's conception of private moral concepts. Such concepts, I suggest, plausibly play an important role in moral thought, and yet moral knowledge expressed in them cannot be testimonially acquired.
Evaluation of CSF1R‐related adult onset leukoencephalopathy with axonal spheroids and pigmented glia diagnostic criteria
Authors: Ayrignac Xavier , Carra‐Dallière Clarisse , Codjia Pekes , Mouzat Kevin , Castelnovo Giovanni , Ellie Emmanuel , Etcharry‐Bouyx Frédérique , Belliard Serge , Marelli Cecilia , Portet Florence , Le Ber Isabelle , Durand‐Dubief Francoise , Mathey Guillaume , Stankoff Bruno , Dorboz Imen , Drunat Severine , Boespflug‐Tanguy Odile , Menjot de Champfleur Nicolas , Lumbroso Serge , Mochel Fanny , Labauge Pierre 
Published: September 2021

AbstractBackground and purposeDiagnostic criteria for adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) due to colony‐stimulating factor 1 receptor (CSF1R) mutation have recently been proposed. Our objective was to assess their accuracy in an independent multicenter cohort.MethodsWe evaluated the sensitivity and specificity of the diagnostic criteria for ALSP (including the “probable” and “possible” definitions) in a national cohort of 22 patients with CSF1R mutation, and 59 patients with an alternative diagnosis of adult onset inherited leukoencephalopathy.ResultsOverall, the sensitivity of the diagnostic criteria for ALSP was 82%, including nine of 22 patients diagnosed as probable and nine of 22 diagnosed as possible. Twenty of the 59 CSF1R mutation‐negative leukoencephalopathies fulfilled the diagnostic criteria, leading to a specificity of 66%.ConclusionsDiagnostic criteria for ALSP have an overall limited sensitivity along with a modest specificity. We suggest that in patients suspected of genetic leukoencephalopathy, a comprehensive magnetic resonance imaging pattern‐based approach is warranted, together with white matter gene panel or whole exome sequencing.
Long‐term seizure outcomes in patients with hypothalamic hamartoma treated by stereotactic radiofrequency thermocoagulation
Authors: Shirozu Hiroshi , Masuda Hiroshi , Kameyama Shigeki 
Published: September 2021

SummaryObjectiveTo investigate long‐term seizure outcomes in patients with hypothalamic hamartoma (HH) following stereotactic radiofrequency thermocoagulation (SRT).MethodsA total of 131 patients with HH who underwent SRT and were followed for at least three years after the last SRT were enrolled. Seizure outcomes were evaluated for gelastic seizures (GS) and other types of seizures (nGS) separately using the International League Against Epilepsy classification. Classes 1 and 2 were considered seizure‐free. Kaplan‐Meier survival analyses were used to estimate the proportion remaining seizure‐free after the first and last SRTs. Risk factors relating to outcomes were analyzed by log‐rank tests and a multivariate Cox proportional hazards model.ResultsReoperation was performed in 34 patients (26.2%). Median total follow‐up was 61 (range, 36–202) months. Seizure freedom was obtained in 116 patients (88.6%) for GS and 85 of 108 patients (78.7%) for nGS at the last follow‐up. Mean GS‐free survival times improved from after the first (64.1 [95%CI 57.3–70.9] months) to after the last SRT (80.2 [95%CI 75.7–84.8] months). About 90% of GS recurrences after the first SRT were found within 6 months, though a few patients recurred more than 2 years after the first SRT. On the other hand, mean nGS‐free survival times after the first and last SRTs were not different between after the first SRT (84.4 [95%CI 73.0–90.7] months) and after the last SRT (83.1 [95%CI 74.1–92.0] months). There was no factor related to GS outcomes, but the significant factor for nGS‐free survival after the last SRT was multiple previous treatments (p=0.01, hazard ratio=15.65, 95%CI 1.79–137.16).SignificanceThe last SRT was almost equivalent to achieving complete disconnection of HHs from the hypothalamus according to our strategy. Considering the epileptogenic network, GS outcomes depend on complete disconnection, whereas nGS outcomes are not affected by surgical factors but independency of secondary epileptogenesis.
Osteomyelitis of the scapulohumeral joint associated withRhodococcus equiand unresponsive to antibiotherapy in a foal
Authors: Labordère A. L. , Rodgerson D. H. , Kennedy L. A. 
Published: September 2021

SummaryThis case report describes the treatment and outcome of a 3.5‐month‐old lame foal, with a history of pneumonia associated withRhodococcus equi. Clinical examination identified osteomyelitis of the scapulohumeral joint. The unusual location of theRhodococcus equiosteomyelitis unresponsive to prevention and adequate treatment led to euthanasia of the patient. Post‐mortem findings confirmed bronchopneumonia due toRhodococcus equias well as the osteomyelitis of the scapulohumeral joint. This case highlights thatRhodococcus equishould be considered as a pathogen in extrapulmonary locations such as septic arthritis and osteomyelitis in foals with history of bronchopneumonia. Early and aggressive treatment should be considered.
Head and tail rope‐assisted recovery improves quality of recovery from general anaesthesia in horses undergoing emergency exploratory laparotomy
Authors: Louro Luís Filipe , Robson Katherine , Hughes Jodie , Loomes Kate , Senior Mark 
Published: September 2021

AbstractBackgroundIn equine anaesthesia, the recovery period is critical, accounting for most anaesthesia‐related fatalities reported. Horses may recover unassisted or may be assisted, for example, using a head and tail rope recovery method.ObjectivesTo compare the impact of head and tail rope and unassisted recovery method on quality of recovery in horses undergoing colic surgery under general anaesthesia (GA).Study designSingle centre retrospective cross‐sectional study, with prospective model performance analysis.MethodsClinical data were obtained from horses undergoing emergency exploratory laparotomy over a 6‐year period. Multivariable logistic regression analysis was used to identify the perioperative factors that affect quality of recovery. The final prediction model was assessed prospectively.ResultsRecords from 502 general anaesthetics (490 horses) were included. Multivariable logistic regression analysis showed that head and tail rope recovery (OR 2.2, 95% CI 1.4‐3.3, P < .001) and sevoflurane administration (OR 1.6, 95% CI 1.2‐2.3, P = .02) were associated with better quality of recovery when compared with unassisted recovery and isoflurane administration respectively. Increasing GA duration (OR 1.0, 95% CI 0.99‐1.0, P = .03), increasing intraoperative dosages (in mg/kg) of thiopental (OR 0.85, 95% CI 0.75‐0.98, P = .02) or ketamine (OR 0.67, 95% CI 0.46‐0.99, P = .04) were linked to poor quality of recovery. No statistically significant difference was found between recovery groups in terms of mortality.Main limitationsThe clinical prediction model obtained is only applicable to the specific facilities, recovery methodology, referral population and anaesthetic protocols practiced at our institution.ConclusionsHead and tail rope recovery is significantly associated with better quality of recovery, compared with unassisted recovery, in horses undergoing emergency exploratory laparotomy. Sevoflurane administration, in detriment of isoflurane, was associated with better quality of recovery. Other risk factors, such as increasing GA duration, the use of higher intra‐operative dosages of ketamine and/or thiopental, were associated with poor quality of recovery.
Interactions between mental illness recovery processes in the family
Authors: Galimidi Netta , Shamai Michal 
Published: September 2021

AbstractObjectivesThis study is designed to understand the experiences of the recovery processes of people with schizophrenia and their parents and to explore the connections between the processes of the different family members.BackgroundThere is extensive evidence in the professional literature that understanding the recovery process of individuals with schizophrenia must include all family members. However, there is a gap in the knowledge regarding the way family members experience both their individual process and its connection to the processes other family members undergo.MethodThis research employed qualitative methodology in which 15 families were interviewed through semistructured interviews (i.e., 15 adult individuals with schizophrenia and their parents). Thematic individual, dyadic, and triadic levels analysis were employed.FindingsTwo main themes emerged: elements of the recovery processes of family members that led toward family recovery and connections among the recovery processes of family members.ConclusionIn spite of the predominance of the pharmacological paradigm in the area of mental health, the family still plays an important role in the recovery process, which is a systemic process involving all family members. As a result, every family member undergoes some processes that contribute to recovery of the others and of the entire system.ImplicationsThe characteristics of the family system interactions during the recovery process should be taken into account in understanding and providing interventions for people with schizophrenia, and should be integrated into all types of interventions provided to these families.
Analoging the digital: Designing better binary option contracts
Authors: Tian Yisong S. 
Published: September 2021

AbstractBinary option pays a fixed dollar amount if it matures in the money and nothing otherwise. While this cash‐or‐nothing payoff structure is very attractive to speculators, it also creates incentives to manipulate the underlying asset price in order to gain extra payoff. In this paper, we propose better designs for binary options that disincentivize market manipulation and highlight two key features of such designs. We demonstrate the effectiveness of the new contract designs using numerical examples.