bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charcot‐Marie‐Tooth disease: Genetic profile of patients from a large Brazilian neuromuscular reference center
Authors: Uchôa Cavalcanti Eduardo Boiteux , Santos Savana Camilla de Lima , Martins Carlos Eduardo Speck , de Carvalho Daniel Rocha , Rizzo Isabela Maria Pinto de Oliveira , Freitas Maria Cristina Del Negro Barroso , da Silva Freitas Denise , de Souza Francineide Sadala , Junior Altamir Monteiro , do Nascimento Osvaldo José Moreira 
Published: July 2021

AbstractThis study aimed to describe the clinical, genetic, and epidemiological features of Charcot‐Marie‐Tooth disease (CMT) in Brazilian patients from a tertiary center, and to compare our data with previously published findings. This retrospective observational study conducted between February 2015 and July 2020 evaluated 503 patients (94 families and 192 unrelated individuals), diagnosed with CMT. Clinical and neurophysiological data were obtained from electronic medical records and blood samples were used for genetic analyses. Multiplex ligation‐dependent probe amplification was used to assess duplications/deletions in PMP22. Sanger sequencing of GJB1 was performed in cases of suspected demyelinating CMT. Targeted gene panel sequencing was used for the remaining negative demyelinating cases and all axonal CMT cases. The first decade of life was the most common period of disease onset. In all, 353 patients had demyelinating CMT, 39 had intermediate CMT, and 111 had axonal CMT. Pathogenic or likely pathogenic variants were identified in 197 index cases. The most common causative genes among probands were PMP22 (duplication) (n = 116, 58.88%), GJB1 (n = 23, 11.67%), MFN2 (n = 12, 6.09%), GDAP1 (n = 7, 3.55%), MPZ (n = 6, 3.05%), PMP22 (point mutation) (n = 6, 3.05%), NEFL (n = 3, 1.52%), SBF2 (n = 3, 1.52%), and SH3TC2 (n = 3, 1.52%). Other identified variants were ≤1% of index cases. This study provides further data on the frequency of CMT subtypes in a Brazilian clinical‐based population and highlights the importance of rarer and previously undiagnosed variants in clinical practice.
Machine learning advances for time series forecasting
Authors: Masini Ricardo P. , Medeiros Marcelo C. , Mendes Eduardo F. 
Published: July 2021

AbstractIn this paper, we survey the most recent advances in supervised machine learning (ML) and high‐dimensional models for time‐series forecasting. We consider both linear and nonlinear alternatives. Among the linear methods, we pay special attention to penalized regressions and ensemble of models. The nonlinear methods considered in the paper include shallow and deep neural networks, in their feedforward and recurrent versions, and tree‐based methods, such as random forests and boosted trees. We also consider ensemble and hybrid models by combining ingredients from different alternatives. Tests for superior predictive ability are briefly reviewed. Finally, we discuss application of ML in economics and finance and provide an illustration with high‐frequency financial data.
Alteration of circulating cell‐free DNA level by external cephalic version: A potential biomarker for direct evaluation of placental damage
Authors: Yabuzaki Keiko , Kamide Taizan , Ejima Ruriko , Tsuruoka Yuto , Sato Mariko , Kondo Ibuki , Hasegawa Akihiro , Sato Taisuke , Samura Osamu , Okamoto Aikou 
Published: July 2021

AbstractAimTo confirm that variations in cell‐free fetal DNA (cffDNA) are indicators of external placental damage, we quantitatively investigated cffDNA alterations in maternal peripheral blood during external cephalic version (ECV).MethodsWe recruited 48 singleton pregnant women who underwent ECV in our hospital. Before and immediately after ECV, we harvested 10 ml of maternal peripheral blood samples for cffDNA analysis. cffDNA alterations were assessed based on the fetal fraction (FF) rate. We performed ECV without epidural anesthesia but administered epidural anesthesia if ECV was disrupted due to severe pain.ResultsThe FF increased from 22.9% ± 5.7% to 27.0% ± 5.7% (p < 0.05) after ECV. The FF increased in both successful (before, 24.4% ± 5.9%; after, 28.1% ± 5.9%; p < 0.05) and unsuccessful (before, 21.8% ± 3.8%; after, 27.3% ± 4.2%; p < 0.05) cases, as well as in patients who received epidural anesthesia (before, 23.9% ± 4.7%; after, 28.5% ± 4.4%; p < 0.05) or underwent ECV more than once (before, 23.5% ± 6.1%; after, 28.4% ± 5.3%; p < 0.05).ConclusionsFF alterations increased due to external stresses during ECV; the alterations were markedly greater when the strength and duration of external stress increased. These FF alterations may serve as potential biomarkers for the direct assessment of placental damage.
Treatment outcomes and complications in FIGO stage IIIC and IVB endometrioid endometrial cancer patients presenting as nodal spreads following systematic lymphadenectomy and adjuvant therapy
Authors: Kong Tae‐Wook , Jo Eunae , Son Joo‐Hyuk , Paek Jiheum , Chang Suk‐Joon , Ryu Hee‐Sug 
Published: July 2021

AbstractObjectiveTo evaluate the treatment outcomes and complications of patients with FIGO stage IIIC and IVB endometrioid endometrial cancer (EC) presenting primarily as nodal spreads following systematic lymphadenectomy and adjuvant therapy.Material and MethodsForty‐four FIGO stage IIIC and IVB endometrioid EC patients between July 2003 and March 2020 received staging procedures including systematic lymphadenectomy. The survival outcomes and late treatment‐related complications were compared between adjuvant chemoradiation‐based group and chemotherapy‐based group.ResultsOf the 44 patients, 16 (36.4%) had stage IIIC1, 26 (59.1%) had stage IIIC2, and 2 (4.5%) had stage IVB disease. The median follow‐up time was 54 months (range, 10–185 months). There was no statistical difference in mortality between the microscopic and macroscopic nodal groups (6.2% vs 4.3%, p > 0.999). Eleven patients (25.0%) and 33 patients (75.0%) received adjuvant chemoradiation and chemotherapy, respectively. The 5‐year disease‐free and overall survival rates were not different between the two groups (disease‐free survival, 81.8% vs 82.1%, p = 0.743; overall survival, 90.9% vs 95.8%, p = 0.537). The incidence rates of grade 2 lymphedema (36.4% vs 9.1%, p = 0.032) and grade 2/3 gastrointestinal complications (36.4% vs 0.0%, p < 0.001) were higher in the chemoradiation‐based group than those in the chemotherapy‐based group.ConclusionsSystematic lymphadenectomy and adjuvant chemotherapy might be the preferred treatment for FIGO stage IIIC and IVB endometrioid EC patients presenting as nodal spreads given that no difference in patient survival was found, but a higher incidence of treatment‐related complications was observed in the chemoradiation‐based group.
Stakeholder Governance for Responsible Innovation: A Theory of Value Creation, Appropriation, and Distribution
Authors: Bacq Sophie , Aguilera Ruth V. 
Published: July 2021

AbstractIn the face of intractable societal grand challenges, organizations increasingly resort to responsible innovation – that is, they pledge to create value for multiple stakeholders through developing new products or services that avoid doing harm and improve conditions for people and the planet. While the link between responsible innovation and societal improvements has been established, organizations pursuing responsible innovation lack governance mechanisms to guide the allocation of the value created – both economic and social – among heterogeneous stakeholders, in line with their responsible intent. We combine the value‐based strategy and stakeholder perspectives and infuse a deliberative process to design a three‐stage model of value allocation that rests on three key organizational decisions: i) what value to create and for whom, ii) how to appropriate the value created vis‐à‐vis unintended value appropriators, and iii) how to distribute the value appropriated among intended stakeholders. We propose a framework of stakeholder governance comprised of four novel mechanisms by which organizations can allocate value among their multiple principal stakeholders as part of participative processes. Our study contributes to responsible innovation and corporate governance research by unpacking how new value is managed to solve societal grand challenges.
Artifacts and errors in the measurement of the stickiness of liquid foods with tack tests
Authors: Kazemeini Seyed Mostafa , Rosenthal Andrew J. 
Published: July 2021

AbstractWe encounter stickiness in many areas of our daily life and as humans, we are able to discriminate different levels of stickiness. Yet attempts to measure stickiness with instruments have been challenging. One of the commonest approaches has been the “tack test” in which a probe is brought into contact with the sticky food and then pulled away while measuring the resisting force—various indices, such as the maximum force or the area below the force curve have been used to describe stickiness. This work rationalizes results from tack tests for liquid foods and helps us explain the influence of probe geometry. Photographic evidence of the way that the liquid adheres/detaches from the probe suggests that the terms “cohesive” and “adhesive” failure depend on the speed of the test. Application of a fixed deformation with time shows rapid loss of adhesive force suggesting that liquid samples flow from the probe. We propose that stickiness of liquid foods is entirely due to the liquid's viscosity and surface tension, and that measurements of tack for liquid foods—while highly reproducible—are entirely artifacts of the test method employed and are in effect snapshots in time of non‐equilibrium processes.
Age‐related changes to the speckle patterns on wild Indo‐Pacific bottlenose dolphins
Authors: Yagi Genfu , Sakai Mai , Kogi Kazunobu 
Published: July 2021

AbstractAge estimating wild dolphins using noninvasive methods will improve our understanding of their ontogeny. Speckles appear on the ventral through to the lateral areas of Indo‐Pacific bottlenose dolphins (Tursiops aduncus) as they age. Age‐related changes in the speckle density and shape were examined using type classification. Speckles first appeared on the ventral area of the genital area at approximately 6.5 years. They increased in two specific directions, from the genital area to the jaw and from the ventral side to the lateral side. The speckle shape changed with aging from a dot‐shape to oblong. Individuals aged over 35 years possessed more speckles than those aged 24–26 years. The oldest age category of dolphins in this study was over 35 years. The speckling area similarly increased with age for all individuals. Therefore, the results suggest that speckle condition can be used to estimate age. The relationship between speckling area and age showed no significant sexual dimorphism except near the genital slit area. There was no speckle area around the genital slit which differed in shape between the sexes. Therefore, speckle patch shape may be a useful sex confirmation tool.
Microbiome‐mediated effects of habitat fragmentation on native plant performance
Authors: Kiesewetter Kasey N. , Afkhami Michelle E. 
Published: July 2021

Summary

Habitat fragmentation is a leading cause of biodiversity and ecosystem function loss in the Anthropocene. Despite the importance of plant–microbiome interactions to ecosystem productivity, we have limited knowledge of how fragmentation affects microbiomes and even less knowledge of its consequences for microbial interactions with plants.

Combining field surveys, microbiome sequencing, manipulative experiments, and random forest models, we investigated fragmentation legacy effects on soil microbiomes in imperiled pine rocklands, tested how compositional shifts across 14 fragmentation‐altered soil microbiomes affected performance and resource allocation of three native plant species, and identified fragmentation‐responding microbial families underpinning plant performance.

Legacies of habitat fragmentation were associated with significant changes in microbial diversity and composition (across three of four community axes). Experiments showed plants often strongly benefited from the microbiome’s presence, but fragmentation‐associated changes in microbiome composition also significantly affected plant performance and resource allocation across all seven metrics examined. Finally, random forest models identified ten fungal and six bacterial families important for plant performance that changed significantly with fragmentation.

Our findings not only support the existence of significant fragmentation effects on natural microbiomes, but also demonstrate for the first time that fragmentation‐associated changes in microbiomes can have meaningful consequences for native plant performance and investment.
Regulatory agencies, reputational threats, and communicative responses
Authors: Bach Tobias , Jugl Marlene , Köhler Dustin , Wegrich Kai 
Published: July 2021

AbstractA key claim in bureaucratic reputation literature is that reputation has several dimensions. This presents agencies with a difficult choice concerning which dimension(s) they should emphasize in the management of their reputation. This paper analyzes how regulatory agencies manage their reputation through communicative responses to public judgments, based on a single‐case study of the German financial regulator BaFin. Our theoretical argument underscores the importance of different reputational dimensions for regulatory agencies that simultaneously considers their distinct reputation reserves. Our main finding was that BaFin prioritizes responses to public judgments targeting reputational dimensions that are central to its mission and for which the agency has a weak reputation, as opposed to judgments targeting dimensions that are central to its mission and for which it has a strong reputation, or judgments targeting peripheral dimensions. The paper demonstrates the importance of agency missions for reputation management and suggests directions for further research.
GGM Knockoff Filter: False Discovery Rate Control for Gaussian Graphical Models
Authors: Li Jinzhou , Maathuis Marloes H. 
Published: July 2021

AbstractWe propose a new method to learn the structure of a Gaussian graphical model with finite sample false discovery rate control. Our method builds on the knockoff framework of Barber and Candès for linear models. We extend their approach to the graphical model setting by using a local (node-based) and a global (graph-based) step: we construct knockoffs and feature statistics for each node locally, and then solve a global optimization problem to determine a threshold for each node. We then estimate the neighbourhood of each node, by comparing its feature statistics to its threshold, resulting in our graph estimate. Our proposed method is very flexible, in the sense that there is freedom in the choice of knockoffs, feature statistics and the way in which the final graph estimate is obtained. For any given data set, it is not clear a priori what choices of these hyperparameters are optimal. We therefore use a sample-splitting-recycling procedure that first uses half of the samples to select the hyperparameters, and then learns the graph using all samples, in such a way that the finite sample FDR control still holds. We compare our method to several competitors in simulations and on a real data set.
A case report of pleuro‐pericardial effusion in a patient on hemodialysis and a cardiac pacemaker
Authors: Jaryal Ajay , Vikrant Sanjay , Sarkar Malay , Asotra Sanjeev , Gupta Dalip , Agarwal Sahil 
Published: July 2021

AbstractThere are multiple causes of pleuro‐pericardial effusion (PPEF) and more so in a patient with end‐stage renal disease (ESRD). Postcardiac injury syndrome (PCIS) is a loosely defined term for occurrence of pericardial and/or pleural effusion (PLEF), low‐grade fever, with or without systemic upset, which occurs after myocardial infarction (MI), and other cardiac interventions. PPEF is one of its salient manifestations. We report occurrence of PCIS, presenting as pericardial effusion and massive PLEF, after insertion of cardiac pacemaker in a patient with ESRD, on maintenance hemodialysis (MHD). It was successfully managed with a short course of oral steroids.
Effect of red blood cell transfusion on inflammation, endothelial cell activation and coagulation in the critically ill
Authors: van Manen Lisa , van Hezel Maike E. , Boshuizen Margit , Straat Marleen , de Man Angelique M. E. , Dekimpe Charlotte , Vanhoorelbeke Karen , van Bruggen Robin , Juffermans Nicole P. 
Published: July 2021

AbstractBackground and ObjectivesRed blood cell (RBC) transfusion is a frequently applied intervention in an intensive care unit. However, transfusion is associated with adverse outcomes including organ failure and thrombo‐embolic events. Mechanisms of these effects are not known but may be related to activation of the endothelium or of the coagulation or inflammatory system. We hypothesized that a RBC transfusion in the critically ill would result in further activation of these systems.Materials and MethodsIn 74 non‐bleeding critically ill patients receiving one RBC unit, markers of inflammation, endothelial cell activation and coagulation were measured before transfusion, at 1 h after transfusion and 24 h after transfusion. The impact of disease severity of the recipient on these changes was assessed by comparing septic and non‐septic patients (according to sepsis‐3 definition) and by correlation of biomarkers with the sequential organ failure assessment (SOFA) score.ResultsLevels of von Willebrand Factor (vWF), soluble ICAM‐1, soluble thrombomodulin, fibrinogen and d‐dimer were already high at baseline, whereas ADAMTS13 levels were low. VWF levels increased significantly 24 h after RBC transfusion (median 478% (338–597) vs. 526% (395–623), p = 0.009). The other biomarkers did not change significantly. Post transfusion change was not dependent on the presence of sepsis and was not correlated with SOFA score.ConclusionRBC transfusion in critically ill patients was associated with an increase in circulating vWF levels, suggesting a further increase in activation of the endothelium, a finding that was independent of the presence of sepsis or organ injury level.
Encoding of vestibular and optic flow cues to self‐motion in the posterior superior temporal polysensory area
Authors: Zhao Bin , Zhang Yi , Chen Aihua 
Published: July 2021

Key points
Neurons in the posterior superior temporal polysensory area (STPp) showed significant directional selectivity in response to vestibular, optic flow and combined visual–vestibular stimuli.
By comparison to the dorsal medial superior temporal area, the visual latency was slower in STPp but the vestibular latency was faster.
Heading preferences under combined stimulation in STPp were usually dominated by visual signals.
Cross‐modal enhancement was observed in STPp when both vestibular and visual cues were presented together at their heading preferences.
AbstractHuman neuroimaging data implicated that the superior temporal polysensory area (STP) might be involved in vestibular–visual interaction during heading computations, but the heading selectivity has not been examined in the macaque. Here, we investigated the convergence of optic flow and vestibular signals in macaque STP by using a virtual‐reality system and found that 6.3% of STP neurons showed multisensory responses, with visual and vestibular direction preferences either congruent or opposite in roughly equal proportion. The percentage of vestibular‐tuned cells (18.3%) was much smaller than that of visual‐tuned cells (30.4%) in STP. The vestibular tuning strength was usually weaker than the visual condition. The visual latency was significantly slower in STPp than in the dorsal medial superior temporal area (MSTd), but the vestibular latency was significantly faster than in MSTd. During the bimodal condition, STP cells’ response was dominated by visual signals, with the visual heading preference not affected by the vestibular signals but the response amplitudes modulated by vestibular signals in a subadditive way.
Low-Speed Vehicle Path-Tracking Algorithm Based on Model Predictive Control Using QPKWIK Solver
Authors: Zhang Yihuai , Shi Baijun , Hu Xizhi , Ai Wandong 
Published: July 2021

Abstract
Automated valet parking is a part of autonomous vehicles. Path tracking is a vital capability of autonomous vehicles. In the scenario of automatic valet parking, the existing control algorithm will produce a high tracking error and a high computational burden. This paper proposes a path-tracking algorithm based on model predictive control to adapt to low-speed driving. By using the model predictive control method and vehicle kinematics model, a path tracking controller is designed. Combining the dual algorithm to further optimize the solver, a new quadratic programming (QP) knows what it knows (QPKWIK) solver is proposed. The simulation results show that the solution time of the QPKWIK solver is 25% less than that of the QP solver, and the tracking error is reduced by up to 41% compared with the QP solver. In the parking lot, the tracking performance is tested under four common scenarios, and the experimental results show that this controller has better tracking performance.
The role of the ultrasound examination in atypical placental site trophoblastic tumour differential diagnosis and management. A case report
Authors: Cirstoiu Monica Mihaela , Sajin Maria , Baros Alexandru , Vasilescu Sorin , Turcan Natalia 
Published: July 2021

Placental site trophoblastic tumour (PSTT) is a very rare and unique form of gestational trophoblastic tumour, representing about 1-2% of all gestational trophoblastic tumours. Usually, the pattern is a slow growing nodule implicating the endometrium and myometrium, accompanied by abnormal uterine bleeding. Three ultrasound types of PSTT are described, but thereis no specific characteristic for diagnosis. We present the case of a patient with an atypical placental site trophoblastic tumour diagnosed two months after a caesarean scar pregnancy. In the presented case there are several particularities, such as the rapid growth and progression of the tumour, the limitation to the myometrium and the difficulty of the differential diagnosis and approach.
#SportPsychMapping: An Exploratory Interview Framework for Sport and Exercise Psychology
Authors: Latinjak Alexander T. , Morelló-Tomás Eduardo , Figal-Gómez Lucia 
Published: July 2021

The aim of this article is to present an exploratory interview framework called #SportPsychMapping that can serve as guidance to practitioners in exploring the psychological reality of individuals and collectives. To meet their aim, in this article, the authors address (a) the context in which the exploratory interview framework was developed, (b) the theoretical structure used to select topics and questions, (c) the structure of the interview, (d) the topics and questions in the central section of the interview, (e) the summary section of the interview, and (f) different ways the exploratory interview framework has been applied. The hallmarks of #SportPsychMapping are the structure that includes an opening, central, and summary section; the central section, in which external variables, biopsychological states and traits, and psychological skills are explored; and the summary section, where an individual map is created with key concepts and phrases that reflect the interviewee’s main responses.