bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microvascular impairments in axial spondyloarthritis associated with Crohn’s disease
Authors: Davydov D. A. , Marchenko V. N. , Shchukina O. B. , Trofimov V. I. , Kuznetsova D. A. , Kholopova I. V. , Lapin S. V. , Lozovaya T. A. , Rubinstein A. A. , Nikiforova E. A. , Vlasov T. D. 
Published: January 2025

Introduction. Spondyloarthritis (SpA) associated with inflammatory bowel disease (IBD) is a disease in the SpA group developing in patients with Crohn’s disease (CD) and ulcerative colitis. Gut-vascular barrier impairments, including increased epithelial permeability and endothelial glycocalyx (EGc) damage, have been demonstrated in both CD and axial SpA (axSpA), and can serve as a pathogenetic basis for the joint development and progression of these diseases.Aim. To evaluate the significance of EGc damage and epithelial permeability markers in patients with CD-associated axSpA.Materials and methods. We examined 22 patients with axSpA associated with CD (group A), 29 patients with axSpA without IBD (group B), 27 patients with CD (group C) and 28 conditionally healthy controls (group D). Calprotectin (FC) and zonulin (FZ) in feces, hyaluronan and syndecan 1 in serum were studied. Perfusion boundary region (PBR) and the Microvascular Health Index (MVHS) were measured by dark-field microscopy in the sublingual region.Results. In patients with CD-associated axSpA, an increase in PBR (p<0.001) and a decrease in MVHS (p=0.001) were revealed in comparison with healthy individuals. Only CD patients revealed decreased serum hyaluronan (p=0.006) associated with colitis and deep ulcers on endoscopy. Increased PBR allowed to identify very high axSpA activity in group A with a sensitivity of 100 % and specificity of 83.3 %. In group A patients, a correlation between hyaluronan and FC was found (ρ=–0.541; p=0.030). A classification tree, including FC, FZ, hyaluronan, and MVHS, was constructed to determine the presence of CD in axSpA patients with an accuracy of 90.2 %.Conclusions. The study of the gut-vascular barrier damage markers allows to improve the methods of diagnosis and assessment of the integral activity of axSpA associated with CD.
Bridging to Caring Economics and a Changed World
Authors: Gault Donald 
Published: January 2025

Bridging is a furniture bank located in Minnesota’s Twin Cities. Since 1987, Bridging has helped make the homes of close to 350,000 people places of dignity and hope. The work of Bridging is built around a remarkable series of partnerships that strongly aligns with Riane Eisler’s concept of caring economics, and Bryan Stevenson’s challenge to us all to take action to change the world. This paper will outline the origins of Bridging, how it operates, and how it represents an inspiring, tangible example of the power of partnership to transform individuals and communities.
Dirty Work: Essential Jobs and the Hidden Toll of Inequality in America
Authors: Burns Joshua 
Published: January 2025

Dirty Work: Essential Jobs and the Hidden Toll of Inequality in America exposes the hidden work we benefit from in the United States. This work is termed dirty work, which is “unethical activity that [has been] delegated to certain agents and then conveniently disavowed” (Press, 2021, p. 5). From working as a mental health counselor in prisons to being on the killing floors of industrial slaughterhouses, this work is deemed essential and beneficial to society but detrimental to the physical and mental health of those who are in it. The author, Eyal Press, traveled throughout the country to interview several people who have worked and experienced dirty work. These first-hand narratives and the in-depth analysis provided an overview of inequitable and dangerous work in the United States and an included argument that these workers deserve visibility, respect, and the challenging of norms through a change in culture and policy.
Unusual brain metastasis from colon cancer
Authors: Vargas-Urbina John , Martinez-Silva Raúl , Rojas-Panta Giuseppe , Ponce-Manrique Gabriel , Flores-Castillo Jerson , Anicama-Lima William 
Published: January 2025

Background:
Brain metastases due to colorectal cancer correspond to 3–5% of all brain metastases. The prognostic factors are based on age, functional status, and single metastasis. Its management is multidisciplinary, with poor prognosis despite the management.

Case Description:
A case of a 64-year-old male presented with symptoms of headache, disorientation, and nausea. The enhanced magnetic resonance image showed a mass in the right frontal horn of the lateral ventricle, contrast enhancing, with irregular borders, but defined, without restriction in diffusion-weighted images, associated with obstructive hydrocephalus. The investigations in search of a primary neoplasm were negative. A ventricular endoscopic approach was performed, with total resection of the lesion. Four months later, he developed a bowel obstruction with surgical management to control the primary, followed by chemotherapy and radiotherapy, with a current survival longer than 1 year.

Conclusion:
Brain metastases due to colorectal cancer are rare, and usually, when diagnosed, there are already pulmonary and hepatic metastases. Multidisciplinary management is recommended, where surgical management can be included in selected cases with controlled systemic disease, good functional condition, and single metastasis.
Efficacy of Melatonin in Neonatal Sepsis with Respiratory Distress: A Randomized Controlled Study
Authors: Hidayah Dwi , Nur Irfani Agita  
Published: January 2025

Background: Neonatal sepsis is a significant condition worldwide, contributing to high morbidity and mortality, especially in developing countries such as Indonesia. Neonatal sepsis can rapidly progress to respiratory distress. Melatonin, an effective antioxidant and free radical scavenger, may be an adjuvant therapy. This study aimed to evaluate the efficacy of melatonin in neonatal sepsis with respiratory distress.
Subjects and Method: A double-blind randomized controlled study was conducted on 42 neonatal sepsis with respiratory distress diagnosed with clinical and laboratory criteria. The subjects were randomly allocated into treatment and control groups, receiving a single dose of oral melatonin 20 mg and a placebo, respectively. The dependent variables were improvement of suplementation in oxygenation and ventilator, outcome, and hospital length of stay. The independent variables was suplementation melatonin The oxygen supplementation and ventilation support were measured at baseline and 72 hours after therapy. We analyzed all data with SPSS 25 using independent t test and determined the significance level at p < 0.050.
Results: Seven of the 21 subjects in the treatment group experienced decreased oxygen supplemen­tation and ventilation support, which was statistically significant (p = 0.009). While the outcome for both groups was the same proportion, it was statistically not significant (p = 1.000).
Conclusion: Melatonin administration significantly decreased oxygen supplementation and ventilation support.
Pengembangan Desain Antarmuka Sistem Informasi Keuangan Kas RT Berbasis Mobile dengan Metode Design Thinking
Authors: Ari Putra Wibowo Ari Putra Wibowo , Arief Soma Dharmawan  , Muhammad Faizal Kurniawan  , Devi Sugianti  , Risqiati  
Published: January 2025

Penelitian ini bertujuan untuk mengembangkan desain antarmuka sistem informasi keuangan Kas RT berbasis mobile dengan menggunakan metode design thinking dimana objek pada penelitian ini adalah RT 06 Kelurahan Kuripan Yosoreko Kecamatan Pekalongan Selatan Kota Pekalongan. RT 06 merupakan salah satu RT yang sudah memanfaatkan teknologi informasi untuk pencatatan dan pelaporan uang Kas Warga. Untuk saat ini sistem informasi yang digunakan pada RT 06 Kelurahan Yosorejo adalah sistem informasi berbasis website dengan beberapa akun pengguna pengurus RT meliputi Ketua RT, Bendahara, Sekretaris dan warga. Metode design thingking digunakan karena dapat digunakan untuk mengeksplorasi berbagai macam kemungkinan yang menitikberatkan pengguna sebagai aktor utama. Adapun tahapan yang dilakukan pada penelitian ini antara lain empathize, define, ideate, prototype dan testing. Hasil penelitian menunjukkan pengembangan desain antarmuka sistem informasi keuangan Kas RT berbasis mobile ini dapat diterima dan bisa digunakan sebagai solusi bagi pengguna. Sesuai dengan pengujian yang dilakukan dengan usability testing, dari beberapa responden yang telah dipilih dapat menyelesaikan semua skenario pengujian pada desain antaramuka baru
The impact of China’s foreign trade on their Actual-Open Emissions of CO2 in the years 2000–2020 in the context of EU energy policy
Authors: FORTUŃSKI Bartosz 
Published: January 2025

Aim: This article aims to analyze the impact of China’s trade with 78 major trading partners on Actual-Open Emission of CO2 (EAO) from 2000 to 2020 in light of the European Union's (EU) goal to reduce CO2 emissions by 20% by 2020 compared to 1990 levels.
Research Methods: The research is based on the Actual-Open Emission of CO2 model and employs the circular flow model to assess the influence of China's foreign trade on CO2 emissions during the years 2000–2020.
Findings: The study revealed that China’s foreign trade significantly influenced its CO2 emissions in all years analyzed, with positive contributions to EAO due to a trade surplus (exports exceeding imports). As the world’s largest exporter and the second-largest importer, China’s trade activity resulted in substantial CO2 emissions. Four key indicators were identified as influencing the difference between Official-Close Emission of CO2 (EOC) and EAO: China’s GDP, the percentage of exported GDP, the percentage of imported GDP, and EOC levels. These findings highlight the significant role of trade in China’s CO2 emissions, which is critical in the context of EU initiatives like “Fit for 55.”
JEL: F18, Q54, Q56,
Potensi Lotion Ekstrak Daun Pandan Wangi (Pandanus Amaryllifolius Roxb.) Sebagai Repellent Nyamuk Culex Sp
Authors: Istikomah Farida Mutik , Suhartinah Suhartinah , Sari Fitri Kurnia 
Published: January 2025

Daun pandan wangi mengandung flavonoid memiliki aktivitas sebagai repellent. Tujuan dilakukannya penelitian ini adalah pemanfaatan daun pandan wangi sebagai pengganti bahan kimia DEET sebagai repellent nyamuk Culex sp . Daun pandan wangi dibuat lotion dengan konsentrasi 4, 8 dan 12% Mutu fisik lotion diamati organoleptik, homogenitas, viskositas, pH, daya sebar, daya lekat, tipe emulsi, dan Cycling test. Metode pengujian efektivtas repellent yaitu dengan memasukkan tangan probandus pada kurungan yang telah berisi 50 ekor nyamuk dan diamati nyamuk menempel pada 5 menit setiap jamnya dengan total pengamatan selama 6 jam. Hasil uji efektivitas repellent dan uji mutu fisik pada formulasi lotion diperoleh hasi dengan konsentrasi 4, 8 dan 12% belum menunjukkan hasil potensi yang efektif karena masih memiliki daya tolak <80%, hasil daya proteksi tertinggi didapatkan dari konsentrasi ekstrak 12% yang memiliki daya tolak sebesar 54,47% semakin besar konsentrasi ekstrak yang ditambahkan maka semakin besar pula daya proteksi yang dihasilkan, tetapi semua formula yang digunakan memiliki uji mutu yang baik.
Kajian Drug Related Problems pada Pasien Diabetes Melitus Tipe 2 yang Terinfeksi Covid-19
Authors: Ratnasari Pande Made Desy 
Published: January 2025

Diabetes Melitus Tipe 2 (DMT2) merupakan salah satu faktor yang memperparah infeksi Covid-19. Studi terdahulu memaparkan tingginya risiko polifarmasi yang berdampak terhadap timbulnya kejadian Drug Related Problems (DRPs) pada penggunaan obat dikedua kondisi tersebut. Penelitian ini bertujuan untuk menganalisis DRPs pada penderita DMT2 yang terinfeksi Covid-19 di RS Swasta kota Denpasar Bali.
Rancangan penelitian adalah cross-sectional pada bulan Juni-Juli 2022. Data dikumpulkan dari rekam medik pasien berdasarkan kriteria inklusi dan eksklusi menggunakan lembar pengambil data. Kriteria inklusi mencakup pasien dengan diagnosis DMT2 yang terinfeksi Covid-19, usia ³18 tahun, rawat inap pada rentang bulan Juli 2020-Juli 2021, mendapatkan pengobatan antidiabetik dan Covid-19. Pasien yang pindah ke RS lain selama perawatan termasuk kriteria eksklusi. Kajian DRPs yang diamati meliputi 6 aspek yaitu indikasi tanpa terapi, terapi tanpa indikasi, obat tidak tepat, dosis obat kurang, dosis obat tinggi, dan interaksi obat yang dianalisis menggunakan pedoman terapi.
Diperoleh 106 data pasien yang mayoritas berjenis kelamin pria (66,98%), berusia 46-65 tahun (70,75%), mengalami demam (30,72%), saturasi oksigen 91-95% (55,66%), glukosa darah 228,38 mg/dL, suhu 36,68°C, derajat keparahan berat (49,06%), lama rawat inap ³10 hari (52,83%), dan status akhir pulang (80,19%). Rata-rata pasien menerima 10,89±3,46 obat. Penggunaan antidiabetik terbanyak yaitu golongan insulin kerja cepat (38,97%) dengan jenis insulin aspart (20,00%). Ditemukan 86,00% peresepan pasien (91 dari 106) setidaknya mengalami 1 jenis DRPs (61,54%). Klasifikasi kejadian DRP meliputi interaksi obat (87,75%), obat tidak tepat (7,28%), dan indikasi tanpa terapi (4,97%). Peran farmasi sangat dibutuhkan untuk mencegah maupun meminimalkan kejadian DRPs.
Analysis of Total Flavonoid and Antioxidant Activity of Ethanol Fraction Watermelon Rind (Citrullus lanatus)
Authors: Rahayu Feronika Evma , Hidayat Dede Irma , Alam Tunas 
Published: January 2025

Antioxidants are required to keep the body's defenses against free radicals intact. Watermelon rind (Citrullus lanatus (Thunb). & Nakai) contains phenolic compounds which are included in the flavonoid group and can act as natural antioxidant compounds. This study evaluated watermelon rind (Citrullus lanatus (Thunb). & Nakai) for its antioxidant activity.
The dried watermelon rind (Citrullus lanatus (Thunb). & Nakai) was extracted using the maceration method and then partitioned into polar (water), non-polar (n-hexane), and semi-polar (ethyl acetate) fractions. Following extraction, the study's methodology is briefly outlined in the second paragraph and is in line with the findings of this publication.
The highest total flavonoid value was found in the watermelon rind (Citrullus lanatus (Thunb). & Nakai) ethanol extract, which measured 49.6 mg/g in the ethyl acetate fraction, 48.6 mg/g in the water fraction, and12.05 mg/g in the n-hexane fraction. The ethyl acetate fraction has strong antioxidant activity (55.36), followed by the water fraction (71.25), and the n-hexane is not strong (225.59).
Calibrating density functionals with DMol3 applied on lithium oxide battery
Authors: Pacheco-Sánchez Juan Horacio , Vera García A. , Desales Guzmán L. A. , Zaragoza I.-P. 
Published: January 2025

Density functional theory - based methods constitute part of the computational techniques considered for finding energy, temperature, pressure, density, electronic structure, and more, of materials and other systems. There is not a general density functional for solving either one or another system, rather there are approximations to the exchange-correlation functional designed to apply this theory, and the density functional for the system in study is usually selected through the Jacob’s Ladder. The purpose of this article is to calibrate by means of selecting multiple density functionals, for calculating potential energy curves on a specific system, and comparing these results with literature values to determine the most suitable functional. With this theory, when a calculation becomes cyclical means that it does not converge after thousands of steps or iterations. The use of thermal smearing calculations can achieve the convergence of the molecular systems. The density functional is calibrated at insignificant thermal smearing values (around 0.005 Hartrees), because the calculated minimum energy is still consistent against experimental values. This level of theory allows searching for stable reaction products. Among the interactions developed to find a suitable density functional are Li + O, Li + O2, Li + CO, 2 LiO– + C38H8. We select GGA-PBE-Grimme as the most suitable density functional. The resulting information is for applying it to infer about charge/discharge of a rechargeable battery, according to the porosity of the cathode.
proceso didáctico del docente a través de la estrategia de enseñanza del estudio de caso y el uso de las tic, en la construcción del conocimiento
Authors: Muñoz García Martha Baría de los Ángeles 
Published: January 2025

La presente investigación, tiene como objetivo general Determinar la manera en la que el proceso didáctico del docente a través de la estrategia de enseñanza del estudio de caso y el uso de las TIC favorecen la construcción del conocimiento en la materia de Estudio e Caso de Instituciones Jurídicas I, de la carrera de Abogado del Centro Universitario del Norte de la Universidad de Guadalajara durante el ciclo escolar 2022-B, es una investigación con alcance descriptivo, realizada bajo el enfoque mixto, con un diseño no experimental realizado de forma transversal;, utilizando los instrumentos de un guion de revisión, la encuesta y entrevista. Al final, se estableció que bajo el proceso didáctico empleado por el docente en la asignatura de ECIJI y el proceso de aprendizaje de los alumnos se centra en el manejo, gestión y producción de la información y que en cada una de las iteraciones del curso el alumno adopta un rol protagónico en su aprendizaje, resaltando que hay mayor presencia de aprendizajes individuales que colectivos y que éstos últimos deben ser adoptados como principales fines por los docentes que imparten este tipo de materias para compartir experiencias y unificar criterios en su impartición.
Effect of Gradation on the Permeability of Foam-conditioned Soils in Mechanized Excavation
Authors: Abdi Barenji Amir , Chakeri Hamid , Manafi Milad , Davarpanah Mortaza 
Published: January 2025

Tunnel excavation in a soft ground is often conducted utilizing excavation machines, including earth pressure balance (EPB) boring machines. A safe and economical excavation using this method requires adding materials such as foam and polymer to the soil inside the chamber and the tunnel face to control parameters like permeability, plasticity, shear resistance, and compressibility. Using an experimental method, the present study investigates the effects of granulation, soil moisture content, and pressure on the permeability of a soil conditioned with foam. According to the results, as the effective grain size (d10) increased from 0.1 to 0.4 mm, the permeability of the conditioned soil grew from 2.28 × 10−5 m/s to 12.3 × 10−5 m/s. A rise in the coefficient of curvature (Cc), while the percentage of the materials passing through the sieve No. 200 was kept constant, increased the permeability coefficient (ki) of the specimens since the medium-grained particles (d30) became coarser. A rise in Cc and the percentage of materials passing through sieve No. 200 resulted in an initial rise in the ki due to the lack of contribution of d30 and a subsequent reduction in it caused by the rise in fine-grained materials. The ki was also found to have inverse relationships with the uniformity coefficient (Cu) and pressure. As Cu increased from 3 to 20, the ki declined from 1.23 × 10−5 m/s to 0.71 × 10−5 m/s.
Pengaruh Ekstrak Daun Murbei (Morus Nigra L.) Sebagai Sabun Dalam Menurunkan Angka Kuman Pada Piring
Authors: Ika irliana rahmadani  , Suyanto Adib , Haryanti Sri 
Published: January 2025

Latar Belakang: Kebersihan peralatan makan penting untuk mencegah penyakit dan menjaga kualitas makanan. Salah satu alat penunjang kebersihan yaitu sabun dengan penambahan antibakteri alami seperti daun murbei karena mengandung flavonoid, alkaloid, saponin, tannin, dan terpenoid yang bersifat antibakteri. Tujuan: Mengetahui pengaruh ekstrak daun murbei (Morus nigra L.) sebagai bahan alami sabun dalam menurunkan angka kuman pada piring di Warung Makan “X” Sleman. Metode: Jenis penelitian eksperimen semu (Quasi Experiment) dengan pendekatan Nonequivalent Control Group Design. Penelitian ini menggunakan quota sampling. Total sampel yang dibutuhkan 24 piring makan kotor. Analisis data menggunakan uji statistik Shapiro-Wilk, kemudian uji One Way Annova dan dilanjutkan uji LSD. Hasil: Rata-rata penurunan angka kuman setelah menggunakan sabun cuci piring ekstrak daun murbei konsentrasi 25% yaitu 134,3 CFU/cm² atau 88,3%, pada konsentrasi 30% yaitu 171,3 CFU/cm² atau 90,8% , konsentrasi 35% yaitu 174,5 CFU/cm² atau 92,3%, dan kontrol menggunakan sabun cuci piring merk “X” yaitu 147,0 CFU/cm² atau 85,2%. Uji One Way Anova menghasilkan p-value 0,012 (Sig. <0,05), menunjukkan perbedaan signifikan dalam penurunan angka kuman dengan penggunaan ekstrak daun murbei. Kesimpulan: Ada pengaruh ekstrak daun murbei sebagai bahan alami pada sabun dalam menurunkan angka kuman pada piring, dengan konsentrasi tertinggi 35% dalam menurunkan angka kuman.
Efektivitas Betta splendens dan Pterophyllum scalare sebagai Predator Jentik Culex sp untuk Penanggulangan Filariasis
Authors: Zikir  , Djaafar Tjitrowati , Sasmita Hanum , Arianty Ros , Susanto S Herlina , Mustafa Mustafa 
Published: January 2025

Latar Belakang: Pemberantasan nyamuk secara kimiawi dapat meningkatkan resistensi nyamuk terhada racun tersebut, oleh karna itu perlu dilakukannya pengendalian sacara biologis dengan menggunakan predator alami yaitu ikan cupang hias dan ikan hias manfihs.Tujuan: untuk mengetahui efektivitas antara ikan cupang hias (betta splendens crown tail) dan ikan hias manfihs (pterophyllum scalare) sebagai predator jentik culex sp dalam upaya penanggulangan filariasis. Metode: Jenis penelitian ini adalah Eksperimen Murni dengan rancangan penelitian desain pra-eksperimen yaitu perlakuan atau intervensi telah dilakukan (X) kemudian dilakukan pengukuran (Observasi) atau post test (O2). Hasil: ikan cupang hias (Betta splendens crown tail) lebih efektif dibandingkan dengan ikan hias manfihs (Pterophyllum scalare) dalam memakan jentik Culex sp. Pada 1 jam pertama Ikan cupang hias mampu memakan sebanyak 25 jentik Culex Sp dari 5 kali pengulangan, sedangkan Untuk Ikan hias manfihs pada 1 jam pertama hanya mampu memakan rata-rata 23 jentik Culex Sp dari 5 kali pengulangan. Kesimpulan: ikan cupang hias lebih efektif dibandingkan ikan hias manfihs sebagai predator jentik Culex sp. Saran untuk Tenaga kesehatan dan puskesmas dapat menggunakan ikan cupang hias (Betta splendens crown tail) sebagai predator alami dari jentik Culex sp dalam upaya penanggulangan filariasis
Perbedaan Dosis Serbuk Biji Kelor (Moringa oleifera) dan Biji Asam Jawa (Tamarindus indica L.) Terhadap Penurunan Kekeruhan Air dengan Metode Jar Test
Authors: Erlisa Hindriani  , Bungawati Andi , Mahyudin Syam Dedi 
Published: January 2025

Latar Belakang: Biji kelor (Moringa oleifera) dan biji asam jawa (Tamarindus indica L) merupakan tanaman yang memiliki potensi sebagai biokoagulan pada proses koagulasi karena kandungan protein. Protein penyusun biji kelor dan biji asam jawa digunakan sebagai alternatif bagi penggunaan koagulan sintetik dalam memperbaiki kualitas kekeruhan air. Tujuan: Tujuan dari penelitian ini adalah diketahuinya perbedaan dosis serbuk biji kelor dan biji asam jawa terhadap penurunan kekeruhan air dengan metode jar test. Metode: Penelitian eksperimen dengan pendekatan eksperimen sungguhan dengan pola penelitian pretest posttest with control (-) group. Sampel dalam penelitian ini yaitu air sungai di kelurahan Taipa dengan cara Grab Sampling. Hasil: Persentase tertinggi penurunan kekeruhan dengan serbuk biji kelor sebesar 38,44% pada dosis 0,2 gr dan persentase tertinggi penurunan kekeruhan dengan serbuk biji asam jawa sebesar 22,83% pada dosis 0,2 gr. Hasil uji T-Test pada jenis koagulan biji kelor dengan rata-rata penurunan 118,300 NTU, sedangkan pada koagulan biji asam jawa terjadi penurunan tingkat kekeruhan dengan rata-rata 134,94 NTU. Kesimpulan: Ada perbedaan rata-rata nilai hasil setelah dilakukan uji coba pada serbuk biji kelor dan biji asam jawa.