bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of polymorphic variants of the renin-angiotensin system, pro-oxidant-antioxidant system and vascular endothelial growth factor as genetic predictors of preeclampsia
Authors: Акуленко Л.В. , Сакварелидзе Н.Ю. , Цахилова С.Г. 
Published: February 2021

В поиске генетических факторов риска развития преэклампсии изучалась роль полиморфных вариантов ключевых генов ренин-ангиотензиновой системы, прооксидантно-антиоксидантной системы и фактора роста эндотелия сосудов, возможно, формирующих ее основные клинические проявления: повышение артериального давления, оксидативный стресс плаценты и эндотелиальную дисфункцию сосудов в системе кровообращения «мать-плацента-плод». Определены достоверные генетические предикторы этого осложнения беременности.
In the search for genetic risk factors for preeclampsia, the role of polymorphic variants of key genes of the renin-angiotensin system, pro-oxidant-antioxidant system, and vascular endothelial growth factor was studied, possibly forming its main clinical manifestations: increased blood pressure, placental oxidative stress, and endothelial vascular dysfunction in the «mother-placenta-fetus» circulatory system. Reliable genetic predictors of this pregnancy complication have been determined.
Molecular mechanisms of imprinted gene disturbance in the embryonic development pathology and recurrent pregnancy loss
Authors: Саженова Е.А. , Лебедев И.Н. 
Published: February 2021

Установлено, что остановка эмбрионального развития человека сопровождается мультилокусными дефектами метилирования импринтированных генов, частота которых повышена в плацентарных тканях спонтанных абортусов от женщин с привычным невынашиванием беременности. Показано, что множественные дефекты метилирования импринтированных генов сопровождаются мутациями гена NLRP7 у спонтанных абортусов от женщин с привычным невынашиванием беременности, а родители являются гетерозиготными носителями данных мутаций.
It was found that disturbances of embryonic development are accompanied by multi-locus imprinting disturbance (MLID), the frequency of which is increased in placental tissues of spontaneous abortions from women with recurrent pregnancy loss. It is shown that MLID are accompanied by NLRP7 gene mutations in spontaneous abortions from women with recurrent pregnancy loss, and parents are heterozygous carriers of these mutations.
Epigenetic modifications of the X chromosome in families with miscarriage
Authors: Толмачева Е.Н. , Саженова Е.А. , Никитина Т.В. , Фонова Е.А. , Лопаткина М.Е. , Затула Л.А. , Лебедев И.Н. 
Published: February 2021

Асимметричная инактивация Х-хромосомы характерна как для женщин с привычным невынашиванием, так и для спонтанных абортусов с кариотипом 46,XX, а смещение инактивации у спонтанного абортуса чаще связано с наличием асимметричной инактивации у матери.
Skewed inactivation of the X chromosome is characteristic for women with recurrent pregnancy loss and spontaneous abortions with a karyotype 46,XX. Skewed X-inactivation in spontaneous abortion is more often associated with the asymmetric inactivation in the mother.
Genetic aspects of the idiopathic form of habitual miscarriage
Authors: Святова Г.С. , Березина Г.М. , Муртазалиева А.В. 
Published: February 2021

Проведенное исследование позволило определить этиологическую обусловленность идиопатических форм привычного невынашивания беременности нарушениями иммунного взаимодействия материнских клеток с синцитиотрофобластом, а также носительством неблагоприятных аллелей риска главного комплекса гистосовместимости HLA 2 класса.
The first time made conducted study to determine the possible etiological condition of idiopathic forms of recurrent miscarriage by impaired immune interaction of maternal cells with syncytiotrophoblast, as well as by carriage of adverse risk alleles of the main HLA histocompatibility complex class 2.
Quantitative polymorphism of tandem repeats as a method of epigenetic regulation of the of human cells response to oxidative stress
Authors: Вейко Н.Н. , Ершова Е.С. , Конькова М.С. , Малиновская Е.М. , Костюк С.В. 
Published: February 2021

Пространственная организация хроматина важна для нормального функционирования клетки. На архитектуру ядра влияют размеры отдельных фрагментов генома, которые коррелируют с числом копий этих фрагментов. Перемещение локусов 1q12 от поверхности ядра в центральные области является ключевой стадией адаптивного ответа клетки на стресс. Мы предположили, что размер локусов 1q12, который коррелирует с содержанием повтора f-SatIII, может влиять на перемещение этих участков хроматина в ядре. Методом FISH на выделенных лимфоцитах показали, что в контроле локусы 1q12 расположены вблизи поверхности ядра, в ядрах лимфоцитов больных шизофренией (БШ) и облученных контрольных клеток локусы 1q12 расположены в центральных районах ядра. Длительное культивирование облученных лимфоцитов сопровождалось гибелью клеток, и снижением содержания f-SatIII в ДНК. Очевидно, что погибали клетки с большим размером 1q12 (много f-SatIII), обогащая популяцию клетками с низким содержанием f-SatIII. В клетках БШ и в облученных клетках мы обнаружили повышение уровня РНК SATIII. Размеры гетерохроматина 1q12 в клетках человека могут влиять на процессы пролиферации и ответа клетки на стресс. Количественный полиморфизм тандемных повторов генома - один из эпигенетических механизмов регуляции ответа клеток на окислительный стресс.
The spatial organization of chromatin is important for the normal functioning of the cell. Genome repeat cluster sizes can affect the chromatin spatial configuration and function. The 1q12 heterochromatin loci movement from the periphery to the center of the nucleus is the cells’ universal response to various types of stress. We hypothesized that a large 1q12 domain could affect chromatin movement, thereby inhibiting adaptive response (AR). Using the FISH method, we shown that in the control, 1q12 loci are located near the surface of the nucleus; in the lymphocyte nuclei of schizophrenic patients and irradiated control cells, 1q12 loci are located in the central regions of the nucleus. During prolonged cultivation, the irradiated cells with a large Large f-SatIII amount die and the population is enriched with the cells with low f-SatIII content. In intact SZ patients’ lymphocytes and in irradiated cells we found an increase in SATIII RNA levels. The size of heterochromatin 1q12 loci in human cells can affect to the proliferation and cells’ adaptive response to stress. Quantitative polymorphism of tandem genome repeats is one of the epigenetic mechanisms of genome expression’s regulation.
Various combinations of genetic factors in men with infertility and their effect on fertility
Authors: Сафина Н.Ю. , Яманди Т.А. , Черных В.Б. , Акуленко Л.В. 
Published: February 2021

Генетические причины снижения фертильности у мужчин представлены изменениями генома как отдельными, так и сочетанными. Целью исследования явилось изучение частоты встречаемости генетических факторов, влияющих на репродукцию, их сочетания и фенотипических проявлениий.
Genetic causes of decreased fertility in men are represented by changes in the genome both separate and combined. The aim of the study was to study the frequency of occurrence of genetic factors leading to impaired reproduction, their combination and phenotypic manifestations.
Pelaksanaan Kebijajakan Akreditasi Sekolah Pada Sekolah Menengah Umum (SMU) Negeri I Toho Kecamatan Toho Kabupaten Mempawah
Authors: Sikwan Agus , Y D Anggreini 
Published: February 2021

This study is entitled: "Implementation of the School Accreditation Policy in the Public High School (SMU) I Toho, Toho District, Mempawah Regency". Using qualitative analysis, the results of this study indicate that the mplementation of the school accreditation system policy implemented by the West Kalimantan Province School Accreditation Board (BAS) towards the Toho I State High School since 2005 has been going well, and has had a positive impact on the average increase passing grade results of the Final School Examination (UAS) obtained by students majoring in Social Sciences and Natural Sciences at Toho I State High School in 2017 to 2018 when compared with the average value of UAS results obtained by Toho I State High School students in 2014, despite the increase in grades the average UAS results obtained by the students were still unsatisfactory for students' parents and the school. The results also showed that the performance of the school principal as the bureaucratic apparatus of the Toho State High School I in providing administrative services to the school community was seen from the aspect of responsiveness which could be said to be good, because school residents felt there was a communication channel provided by the Toho District Education Office to convey their aspirations. In addition, the ability of the bureaucratic apparatus at the Toho District Education Office to recognize what the school community wants through direct interaction with them, causes the demands and desires of the school community to be poured by the Toho subdistrict Education Office in the form of a work program which then get a positive response from the principal of Toho I State High School to implement it.
Pengajaran Bahasa Inggris Menggunakan Media Audio Visual di Raudhatul Atfal (RA) Dharma Wanita Persatuan Simpang
Authors: Muklas M , Agustina Eka , Andriani Dwi 
Published: February 2021

This Community Service aims to provide assistance in learning English about pronunciation of vocabulary using Audio Visual and providing knowledge about the use of Audio Visual media for teachers and learning for students. The chosen partners in this service are children an teachers of Raudhatul Atfal (RA) Dharma Wanita eersatuan Simpang, Buay Pemaca, OKU Selatan, with the consideration that they rarely learn English because there is no English teacher in the RA in using learning methods. In addition, based on observations in the RA, it shows that children's lack of interest in learning English and even English for them is too ordinary / foreign. The target in this service is to help the children of RA Dharma Wanita Persatuan Simpang to learn English so that they do not feel unfamiliar / unfamiliar and increase student motivation in learning English and minimize errors in speaking vocabulary in English. From the results of this service activity, it can be concluded that learning English by utilizing audio-visual media in students of RA Dharma Wanita Persatuan Simpang is proven to contribute significantly to the mastery of the English vocabulary of students.
Pengaruh Perilaku Pengambilan Resiko Dan Kelompok Referensi Terhadap Niat Berwirausaha Mahasiswa Pendidikan Ekonomi STKIP Nurul Huda Kabupaten Oku Timur
Authors: Afifah Siti 
Published: February 2021

Penelitian ini bertujuan untuk menganalisis pengaruh perilaku pengambilan resiko dan kelompok referensi terhadap niat berwirausaha. populasi penelitian ini adalah Mahasiswa Pendidikan Ekonomi Semester I, III dan V di STKIP dengan total 273 Mahasiswa. Pengambilan sampel mengunakan teknik sensus. Teknik pengumpulan data menggunakan kuesioner. Penelitian ini merupakan penelitian kuantitatif dengan analisis regresi linear berganda. Hasil menunjukkan bahwa ada pengaruh yang signifikan perilaku pengambilan resiko terhadap niat berwirausaha. ada pengaruh yang signifikan kelompok referensi terhadap niat berwirausaha. Secara simultan terdapat pengaruh perilaku pengambilan resiko dan kelompok referensi pada niat berwirausaha.
PENGARUH KONDISI SOSIAL EKONOMI ORANG TUA TERHADAP MOTIVASI SISWA MELANJUTKAN STUDI KE PERGURUAN TINGGI KELAS XII SMA MUHAMMADIYAH 2 KARANG TENGAH
Authors: Arianah Arianah , Susanti Dwi , Effendi Effendi 
Published: February 2021

Kondisi sosial ekonomi orang tua merupakan salah satu faktor eksternal timbulnya motivasi siswa untuk melanjutkan pendidikan. yang menjadi salah satu alasan siswa kelas XII SMA Muhammadiyah 2 Karang Tengah untuk tidak meneruskan ke Perguruan Tinggi adalah dikarenakan tekanan ekonomi. Selain itu, pekerjaan orang tua siswa 90% buruh dan petani. Pendidikan orang tua 65% lulusan SD dan SMP. Hal ini menjadi kendala bagi kelanjutan pendidikan untuk meneruskan ke Perguruan Tinggi. Tujuan dalam penelitian ini untuk mengetahui ada tidaknya pengaruh kondisi sosial ekonomi orang tua terhadap motivasi siswa dalam melanjutkan studi ke Perguruan Tinggi kelas XII SMA Muhammadiyah 2 Karang Tengah. Penelitian ini termasuk penelitian kuantitatif. Populasi dalam penelitian ini adalah kelas XII IPS SMA Muhammadiyah 2 Karang Tengah yang berjumlah 90 peserta didik. Sampel penelitian ini adalah kelas XII SMA Muhammadiyah 2 Karang Tengah yang berjumlah 39 peserta didik. Teknik pengumpulan data digunakan koesioner, sedangkan analisis data menggunakan regresi linier sederhana. Hasil akhir penelitian ini adalah Tidak terdapat pengaruh kondisi sosial ekonomi orang tua terhadap motivasi siswa dalam melanjutkan studi ke Perguruan Tinggi kelas XII SMA Muhammadiyah 2 Karang Tengah dengan harga thitung = –0,912 < -t0,05; 37 = –1,687 sehingga Ho diterima, sehingga Ha ditolak.
Kuasa Ideologi Organisasi Keagamaan dalam Novel Adam Hawa dan Tuhan Izinkan Aku Menjadi Pelacur Karya Muhidin M Dahlan Serta Relevansinya pada Bahan Ajar Mata Kuliah Kritik Sastra
Authors: Afkar Taswirul , Mardiana Wiwik 
Published: February 2021

The Power of Religious Organization Ideology in Adam Hawa and Tuhan Izinkan Aku Menjadi Pelacur Novels Written by Muhidin M Dahlan With The Relevancy in Literary Criticisim Course Teaching Materials ABSTRAKTujuan penelitian ini untuk mendeskripsikan hegemoni ideologi organisasi keagamaan dalam novel Adam Hawa dan Tuhan Izinkan Aku Menjadi Pelacur karya Muhidin M Dahlan (Gus Muh). Hasil identifikasi ini memiliki relevansi dengan Capaian Pembelajaran Mata Kuliah (CPMK) Kritik Sastra. Penelitian ini berjenis kualitatif dengan pendekatan sosiologi sastra. Analisis menggunakan analisis isi. Hasil penelitian menunjukkan bahwa hegemoni ideologi dalam organisasi keluarga dan keagamaan berbentuk patriarki dan materialisme. Oleh karena itu, kedua novel berpotensi sebagai bahan ajar mata kuliah Kritik Sastra pada kompetensi keterampilan umum dan khusus.Kata kunci: Hegemoni, Sastra, Pendidikan ABSTRACTThis research aims to describe ideological hegemony in Adam Hawa and Tuhan Izinkan Aku Menjadi Pelacur written by Muhidin M Dahlan (Gus Muh). The result of the study has relevance with the learning outcomes of the literary criticism course. This research is qualitative with sociology literature approach. Content analysis is used in the analysis. The result of the research shows that the ideological hegemony in family and religious organization are in forms of patriarchy and materialism. It means that these novels are potential in teaching materials for literary criticism course on both specific and general skill competences.Keywords: Hegemony, Literature, Education
PENGARUH LATIHAN SENAM SEHAT INDONESIA TERHADAP PENINGKATAN KAPASITAS PARU-PARU BAGI LANSIA DI UNIVERSITAS MAJALENGKA
Authors: Indrayogi Indrayogi , Nurhayati Maya 
Published: February 2021

Dalam pembinaan usia lanjut di Perguruan Tinggi belum ada kegiatan untuk memelihara kondisi fisik. Melalui kegiatan olahraga yang sebenarnya sangat berpotensi untuk dilaksanakan karena banyak lansia di lingkungan Universitas Majalengka. Selain itu dengan melakukan aktifitas fisik berupa latihan yang dapat mencukupi kebutuhan oksigen yang diperlukan pada waktu kerja atau latihan maka diharapkan dapat memelihara dan meningkatkan kesegaran jasmani, karena oksigen tidak dapat di simpan sebagai persediaan dalam tubuh maka yang dapat dilakukan adalah menjaga dan meningkatkan kemampuan organ-organ tubuh yang berfungsi menyerap dan menyalurkan oksigen agar selalu dalam kondisi baik. Metode penelitian ini adalah metode quasi eksperiment dengan jenis pre-test and post-test group without control design. Populasi dalam berjumlah 20 orang lansia yang ada di Universitas Majalengka, semua populasi dijadikan sampel. Instrument yang digunakan dalam penelitian ini adalah Spirometer yang dimodifkasi. Alat ini digunakan untuk melakukan pengukuran kapasitas vital paru. Berdasarkan hasil penelitian dapat diambil kesimpulan bahwa Senam Sehat Indonesia dapat mempengaruhi dan memberikan kontribusi yang signifikan terhadap peningkatan kapasitas vital paru usia lanjut.
PENINGKATAN KEMAMPUAN KOMUNIKASI MAHASISWA PADA MATA KULIAH MANAGEMEN PEMASARAN MENGGUNAKAN METODE KOOPERATIF TIPE JIGSAW
Authors: Yuliani Endah , Nurdiana Ratna , Misidawati Dwi Novaria , Sofwani Siti Aniqoh 
Published: February 2021

Penelitian ini dilatarbelakangi rendahnya komunikasi menyampaikan gagasan/ide mahasiswa dalam proses pembelajaran di kelas pada mata kuliah Managemen Pemasaran. Tujuan penelitian ini untuk meningkatakan kemampuan komunikasi mahasiswa pada mata kuliah Managemen Pemasaran menggunakan metode Kooperatif tipe Jigsaw pada mahasiswa kelas IIA Prodi Managemen STIE Semarang Tahun Akademik 2019/2020. Subjek penelitian ini mahasiswa kelas IIA semester 4 Prodi Managemen dengan jumlah mahasiswa 40 orang terdiri dari 32 perempuan dan 8 laki-laki. Penelitian ini menggunakan metode Penelitian Tindakan Kelas (PTK) merujuk pada desain pola PTK menurut Kemmis & Taggart yang terdiri dari 3 siklus, masing-masing siklus terdiri dari perencanaan, pelaksanaan, observasi, dan refleksi. Teknik pengumpulan data menggunaan observasi, tes, dokumentasi, dan angket. Hasil penelitian ini menunjukkan bahwa metode kooperatif tipe jigsaw dapat meningkatkan kemampuan komunikasi yang signifikan setelah dilakukan tindakan sebanyak tiga siklus. Disamping itu, metode kooperatif tipe jigsaw dapat meningkatkan hasil belajar mahasiswa pada mata kuliah Managemen Pemasaran. Berdasarkan hasil penelitian dapat disimpulkan bahwa metode kooperatif tipe jigsaw dapat meningkatkan kemampuan komunikasi menyampaikan gagasan/ide dan hasil belajar mata kuliah Managemen Pemasaran pada mahasiswa kelas IIA Prodi Managemen STIE Semarang Tahun Akademik 2019/2020.
Reproductive Factors and Breast Cancer Prognosis: The Possible Role of Cesarean Delivery
Authors: Oguz Seda Hanife , Utkan Güngör 
Published: February 2021

Objective: To evaluate the possible associations between tumor pathological characteristics and reproductive factors in women with breast cancer, including method of child delivery.
Materials and Methods: Patients diagnosed as breast cancer between January 2012 and April 2013 in Ankara University Hospitals who had at least one full term pregnancy were included. Data upon pathological prognostic features of tumors and reproductive history of patients were obtained from patient files.
Results: 434 patients with breast cancer were included. Mean age at the time of breast cancer diagnosis was 49.2±10.7 years. History of at least one cesarean delivery was present in 17% of the patients (n=75). Axillary lymph node positivity was related to younger age at first full-term pregnancy (p=0.018), and higher number of parities (p=0.001) in estrogen receptor positive (ER+) breast cancer patients. Although extracapsular invasion was related to shorter time interval since last parity to cancer diagnosis in the whole population (p=0.029), this association disappeared when patients were categorized according to ER status. However, in ER+ patients, history of cesarean delivery was associated with extracapsular invasion (p=0.023). Also, our findings indicated that patients with history of cesarean delivery were diagnosed with breast cancer at younger ages, and after a shorter time interval since last parity (p<0.001). Tumor size (p=0.001), grade (p=0.046), axillary lymph node positivity (p=0.001), lymphovascular invasion (p<0.001), and shorter duration of time since last parity to breast cancer diagnosis (p=0.029) were indicators of metastatic disease.
Conclusion: Our findings indicate that history of cesarean delivery may be associated with poor prognosis in ER+ patients with breast cancer.
Efficacy of Nutrition Screening Tools in Predicting the Length of Hospital Stay in Older Hospitalized Patients
Authors: Balcı Cafer 
Published: February 2021

Objective: The prevalence of malnutrition remains high in older hospitalized patients. Subjective Global Assessment, the Nutrition Risk Screening-2002, and Malnutrition Universal Screening Tool are widely used screening and assessment tools, but comparison of their efficacy in predicting clinical outcomes like length of hospital stay remain scarce. This study aimed to compare the efficacy of these tools in predicting length of hospital stay in a group of older hospitalized patients.
Materials and Methods: A retrospective analysis was performed in a sample of 72 patients consecutively admitted to a geriatric medicine ward. Subjective Global Assessment, Nutrition Risk Screening-2002 and Malnutrition Universal Screening Tool were performed within 24 hours of admission. Patients were classified as having prolonged length of hospital stay if they stay in the hospital for more than ten days. The association of baseline malnutrition defined by each tool and the prolonged length of hospital stay was assessed using unadjusted and adjusted logistic regression models.
Results: The mean age of the patients was 73.5 ± 6.9 years, and 61.1% were women. The prevalence of malnutrition was 45.8% with Subjective Global Assessment, 51.4% with Nutrition Risk Screening-2002, and 33.3% with Malnutrition Universal Screening Tool. Among the entire cohort, twenty-nine patients (40.2%) had longer length of the hospital stay. After adjusted for covariates, multivariate logistic regression analysis revealed that the Subjective Global Assessment had the best predictive power (OR: 3.9; p: 0.02), followed by Nutrition Risk Screening-2002 (OR: 3.8; p: 0.03), and Malnutrition Universal Screening Tool (OR: 2.9; p: 0.02).
Conclusion: Malnutrition assessed by the Subjective Global Assessment, Nutrition Risk Screening-2002 and Malnutrition Universal Screening Tool on admission predict prolonged length of hospital stay in hospitalized older patients.