bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmic inflation in minimal $$U(1)_{B-L}$$ model: implications for (non) thermal dark matter and leptogenesis
Authors: Borah Debasish , Das Suruj Jyoti , Saha Abhijit Kumar 
Published: February 2021

AbstractWe study the possibility of realising cosmic inflation, dark matter (DM), baryon asymmetry of the universe (BAU) and light neutrino masses in non-supersymmetric minimal gauged $$B-L$$

B
-
L

extension of the standard model with three right handed neutrinos. The singlet scalar field responsible for spontaneous breaking of $$B-L$$

B
-
L

gauge symmetry also plays the role of inflaton by virtue of its non-minimal coupling to gravity. While the lightest right handed neutrino is the DM candidate, being stabilised by an additional $$Z_2$$

Z
2

symmetry, we show by performing a detailed renormalisation group evolution (RGE) improved study of inflationary dynamics that thermal DM is generally overproduced due to insufficient annihilations through gauge and scalar portals. This happens due to strict upper limits obtained on gauge and other dimensionless couplings responsible for DM annihilation while assuming the non-minimal coupling to gravity to be at most of order unity. The non-thermal DM scenario is viable, with or without $$Z_2$$

Z
2

symmetry, although in such a case the $$B-L$$

B
-
L

gauge sector remains decoupled from the inflationary dynamics due to tiny couplings. We also show that the reheat temperature predicted by the model prefers non-thermal leptogenesis with hierarchical right handed neutrinos while being consistent with other requirements.
Bounce cosmology in $$f({\mathcal {R}})$$ gravity
Authors: Ilyas M. , Rahman W. U. 
Published: February 2021

AbstractIn this paper, we analyze the modified $$f({\mathcal {R}})$$

f
(
R
)

gravity models in Friedmann–Lemaître–Robertson–Walker (FLRW) background. The actions of bouncing cosmology are studied under consideration of different viable models in $$f({\mathcal {R}})$$

f
(
R
)

gravity theory that can resolve the difficulty of singularity in standard Big-Bang cosmology. Under different viable models in $$f({\mathcal {R}})$$

f
(
R
)

gravity theory, the cosmological constraints are plotted in provisions of cosmic-time, then investigated the bounce circumstance. In addition, the red-shift parameter is used to reconstruct the modified gravity, and compile the cosmological parameters that infer accelerated universe expansion. Finally, the situation stability is evaluated with a sound speed feature, which illustrates late-time stability.
The BDX-MINI detector for Light Dark Matter search at JLab
Authors: Battaglieri M. , Bisio P. , Bondí M. , Celentano A. , Cole P. L. , De Napoli M. , De Vita R. , Marsicano L. , Ottonello G. , Parodi F. , Randazzo N. , Smith E. S. , Snowden-Ifft D. , Spreafico M. , Whitlatch T. , Wood M. H. 
Published: February 2021

AbstractThis paper describes the design and performance of a compact detector, BDX-MINI, that incorporates all features of a concept that optimized the detection of light dark matter in the MeV-GeV mass range produced by electrons in a beam dump. It represents a reduced version of the future BDX experiment expected to run at JLAB. BDX-MINI was exposed to penetrating particles produced by a 2.176 GeV electron beam incident on the beam dump of Hall A at Jefferson Lab. The detector consists of 30.5 kg of PbWO$$_4$$

4

crystals with sufficient material following the beam dump to eliminate all known particles except neutrinos. The crystals are read out using silicon photomultipliers. Completely surrounding the detector are a passive layer of tungsten and two active scintillator veto systems, which are also read out using silicon photomultipliers. The design was validated and the performance of the robust detector was shown to be stable during a six month period during which the detector was operated with minimal access.
Egyptology and Global History: Between Geocultural Power and the Crisis of Humanities
Authors: Moreno García Juan Carlos 
Published: February 2021

Abstract
Globalization, the decline of Western hegemony, and the rise of new political and economic actors, particularly in East Asia, are concomitant with the emergence of more encompassing historical perspectives, attentive to the achievements and historical trajectories of other regions of the world. Global history provides thus a new framework to understanding our past that challenges former views based on the cultural needs, values, and expectations of the West. This means that humanities and social sciences are subject to intense scrutiny and pressed to adapt themselves to a changing cultural, academic, and intellectual environment. However, this process is hindered by the gradual loss of their former prestige and by the increasing influence of economics in the reorganization of the educational, research, and cultural agenda according to market-oriented criteria. The result is that the mobilization of the past increasingly conforms to new strategies in which connectivity, trading, and diplomatic interests, as well as integration in dynamic flows of wealth, appear of paramount importance. Egyptology is not alien to these challenges, which will in all probability reshape its very foundations in the foreseeable future.
Convection-Permitting Regional Climate Change Simulations for Understanding Future Climate and Informing Decision-Making in Africa
Authors: Senior Catherine A. , Marsham John H. , Berthou Ségolène , Burgin Laura E. , Folwell Sonja S. , Kendon Elizabeth J. , Klein Cornelia M. , Jones Richard G. , Mittal Neha , Rowell David P. , Tomassini Lorenzo , Vischel Théo , Becker Bernd , Birch Cathryn E. , Crook Julia , Dougill Andrew J. , Finney Declan L. , Graham Richard J. , Hart Neil C. G. , Jack Christopher D. , Jackson Lawrence S. , James Rachel , Koelle Bettina , Misiani Herbert , Mwalukanga Brenda , Parker Douglas J. , Stratton Rachel A. , Taylor Christopher M. , Tucker Simon O. , Wainwright Caroline M. , Washington Richard , Willet Martin R. 
Published: February 2021

AbstractPan-Africa convection-permitting regional climate model simulations have been performed to study the impact of high resolution and the explicit representation of atmospheric moist convection on the present and future climate of Africa. These unique simulations have allowed European and African climate scientists to understand the critical role that the representation of convection plays in the ability of a contemporary climate model to capture climate and climate change, including many impact-relevant aspects such as rainfall variability and extremes. There are significant improvements in not only the small-scale characteristics of rainfall such as its intensity and diurnal cycle, but also in the large-scale circulation. Similarly, effects of explicit convection affect not only projected changes in rainfall extremes, dry spells, and high winds, but also continental-scale circulation and regional rainfall accumulations. The physics underlying such differences are in many cases expected to be relevant to all models that use parameterized convection. In some cases physical understanding of small-scale change means that we can provide regional decision-makers with new scales of information across a range of sectors. We demonstrate the potential value of these simulations both as scientific tools to increase climate process understanding and, when used with other models, for direct user applications. We describe how these ground-breaking simulations have been achieved under the U.K. Government’s Future Climate for Africa Programme. We anticipate a growing number of such simulations, which we advocate should become a routine component of climate projection, and encourage international coordination of such computationally and human-resource expensive simulations as effectively as possible.
Implementation of pre-captured videos for remote cytological evaluation of salivary gland lesions
Authors: Archondakis Stavros , Roma Maria , Evropi Kaladelfou 
Published: February 2021

Objective The objective of this study was to examine the feasibility of implementing videos captured by static telecytological applications for remote cytological evaluation of fine needle aspiration specimens from salivary gland lesions. Methods The current study was carried out on 102 fine needle aspiration specimens from salivary gland lesions with histological confirmation (benign lesions, 11; benign neoplasms, 68; malignant neoplasms, 23), retrospectively selected from the department’s registry. Videos were transferred via file transfer protocol to password-protected accounts for remote review by three independent cytopathologists. In addition to diagnosis, reviewers commented on overall digital video quality. Contributor’s and reviewer’s diagnoses were collected, recorded and statistically evaluated. Results Statistical evaluation of cytological diagnoses detected no significant difference in diagnostic accuracy between the diagnoses proffered on the basis of pre-captured videos and conventional slides. The overall interobserver agreement was ranging from substantial to almost perfect with κ values of 0.71–0.89. Conclusions Video production by static telecytology applications can be used as an alternative method for telecytological diagnosis of salivary gland fine needle aspirations. Videos of salivary gland fine needle aspirations can be used for rapid and accurate diagnosis, by diminishing turn-around times and improving the quality indices of small cytology departments. They can also be used for archiving, teleconsultation, educational and second opinion purposes, improving the performance of the already existing static telecytology stations.
The Significance of Extra-Cage Bridging Bone via Radiographic Lumbar Interbody Fusion Criterion
Authors: Lee Jeongik , Lee Dong-Hoon , Jung Chan-Woo , Song Kwang-Sup 
Published: February 2021

Study Design: Prospective observational study. Objectives: We aimed to analysis the distributional patterns of the intra- and extra-cage bridging bone (InCBB and ExCBB) and the significance of ExCBB using suggested lumbar interbody fusion criterion. Methods: This study included the patients with planned single-level transforaminal lumbar interbody fusion. We divided bridging bone into InCBB (in void of right or left cage) and ExCBB (outside of cages; anterior, posterior, intermediate, right, or left) and graded bridging scores from 0 to 2 on postoperative 1-year computed tomography. The fusion was defined as at least having one or more graded 2 and the evaluation were conducted twice by 2 raters. Results: Sixty-five patients were enrolled. All values of intra- and inter-rater reliability in left InCBB, anterior, and posterior ExCBB showed good agreements (≥0.75). Both InCBBs showed similar mean bridging scores (Rt:1.43 vs Lt:1.48), and in ExCBBs, the anterior was the highest (1.43), followed by the posterior (1.14); the right and left were the lowest (0.49 and 0.52 respectively). In subjects determined as fusion (85.4%), complete bridging was observed more in ExCBB (88.8%) than in InCBB (69.9%). Conclusions: Given the higher bridging scores in both InCBBs and Ant. ExCBB, bone grafting is important promoting factor to increase the interbody bridging bone regardless of outside or in void of cages. Based on our suggested criterion, ExCBB has a greater proportion compared to InCBBs for determining the fusion and extra-cage bone grafting should be considered as important procedures for interbody fusion.
Cost-effectiveness of azacitidine and venetoclax in unfit patients with previously untreated acute myeloid leukemia
Authors: Patel Kishan K. , Zeidan Amer M. , Shallis Rory M. , Prebet Thomas , Podoltsev Nikolai , Huntington Scott F. 
Published: February 2021

Abstract
The phase 3 VIALE-A trial reported that venetoclax in combination with azacitidine significantly improved response rates and overall survival compared with azacitidine alone in older, unfit patients with previously untreated acute myeloid leukemia (AML). However, the cost-effectiveness of azacitidine-venetoclax in this clinical setting is unknown. In this study, we constructed a partitioned survival model to compare the cost and effectiveness of azacitidine-venetoclax with azacitidine alone in previously untreated AML. Event-free and overall survival curves for each treatment strategy were derived from the VIALE-A trial using parametric survival modeling. We calculated the incremental cost-effectiveness ratio (ICER) of azacitidine-venetoclax from a US-payer perspective. Azacitidine-venetoclax was associated with an improvement of 0.61 quality-adjusted life-years (QALYs) compared with azacitidine alone. However, the combination led to significantly higher lifetime health care costs (incremental cost, $159 595), resulting in an ICER of $260 343 per QALY gained. The price of venetoclax would need to decrease by 60% for azacitidine-venetoclax to be cost-effective at a willingness-to-pay threshold of $150 000 per QALY. These data suggest that use of azacitidine-venetoclax for previously untreated AML patients who are ineligible for intensive chemotherapy is unlikely to be cost-effective under current pricing. Significant price reduction of venetoclax would be required to reduce the ICER to a more widely acceptable value.
Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients
Authors: Munker Dieter , Osterman Andreas , Stubbe Hans , Muenchhoff Maximilian , Veit Tobias , Weinberger Tobias , Barnikel Michaela , Mumm Jan-Niclas , Milger Katrin , Khatamzas Elham , Klauss Sarah , Scherer Clemens , Hellmuth Johannes C. , Giessen-Jung Clemens , Zoller Michael , Herold Tobias , Stecher Stephanie , de Toni Enrico N. , Schulz Christian , Kneidinger Nikolaus , Keppler Oliver T. , Behr Jürgen , Mayerle Julia , Munker Stefan 
Published: February 2021

A fraction of COVID-19 patients progress to a severe disease manifestation with respiratory failure and the necessity of mechanical ventilation. Identifying patients at risk is critical for optimised care and early therapeutic interventions. We investigated the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding relative to disease severity.We analysed nasopharyngeal and tracheal shedding of SARS-CoV-2 in 92 patients with diagnosed COVID-19. Upon admission, standardised nasopharyngeal swab or sputum samples were collected. If patients were mechanically ventilated, endotracheal aspirate samples were additionally obtained. Viral shedding was quantified by real-time PCR detection of SARS-CoV-2 RNA.45% (41 out of 92) of COVID-19 patients had a severe disease course with the need for mechanical ventilation (severe group). At week 1, the initial viral shedding determined from nasopharyngeal swabs showed no significant difference between nonsevere and severe cases. At week 2, a difference could be observed as the viral shedding remained elevated in severely ill patients. A time-course of C-reactive protein, interleukin-6 and procalcitonin revealed an even more protracted inflammatory response following the delayed drop of virus shedding load in severely ill patients. A significant proportion (47.8%) of patients showed evidence of prolonged viral shedding (>17 days), which was associated with severe disease courses (73.2%).We report that viral shedding does not differ significantly between severe and nonsevere COVID-19 cases upon admission to the hospital. Elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe disease course.
SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets
Authors: Li Yue , Duche Ashley , Sayer Michael R. , Roosan Don , Khalafalla Farid G. , Ostrom Rennolds S. , Totonchy Jennifer , Roosan Moom R. 
Published: February 2021

Abstract
Background
The ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mechanism is mostly unknown. Previous studies that characterized differential gene expression due to SARS-CoV-2 infection lacked robust validation. Although vaccines are now available, effective treatment options are still out of reach.

Results
To characterize the transcriptional activity of SARS-CoV-2 infection, a gene signature consisting of 25 genes was generated using a publicly available RNA-Sequencing (RNA-Seq) dataset of cultured cells infected with SARS-CoV-2. The signature estimated infection level accurately in bronchoalveolar lavage fluid (BALF) cells and peripheral blood mononuclear cells (PBMCs) from healthy and infected patients (mean 0.001 vs. 0.958; P < 0.0001). These signature genes were investigated in their ability to distinguish the severity of SARS-CoV-2 infection in a single-cell RNA-Sequencing dataset. TNFAIP3, PPP1R15A, NFKBIA, and IFIT2 had shown bimodal gene expression in various immune cells from severely infected patients compared to healthy or moderate infection cases. Finally, this signature was assessed using the publicly available ConnectivityMap database to identify potential disease mechanisms and drug repurposing candidates. Pharmacological classes of tricyclic antidepressants, SRC-inhibitors, HDAC inhibitors, MEK inhibitors, and drugs such as atorvastatin, ibuprofen, and ketoconazole showed strong negative associations (connectivity score < − 90), highlighting the need for further evaluation of these candidates for their efficacy in treating SARS-CoV-2 infection.

Conclusions
Thus, using the 25-gene SARS-CoV-2 infection signature, the SARS-CoV-2 infection status was captured in BALF cells, PBMCs and postmortem lung biopsies. In addition, candidate SARS-CoV-2 therapies with known safety profiles were identified. The signature genes could potentially also be used to characterize the COVID-19 disease severity in patients’ expression profiles of BALF cells.
Hyperhomocysteinemia and its relations to conventional risk factors for cardiovascular diseases in adult Nigerians: the REMAH study
Authors: Chori Babangida S. , Danladi Benjamin , Inyang Bassey A. , Okoh Michael P. , Nwegbu Maxwell M. , Alli Adewale L. , Odili Augustine N. 
Published: February 2021

AbstractBackgroundEvidence linking homocysteine (Hcy) with cardiovascular diseases (CVD) or its risk factors are limited in a sub-Saharan black population.ObjectiveWe set out to evaluate the association between Hcy and hypertension and other CVD risk factors in a population of adult Nigerians.MethodsData of 156 adults aged 18–70 years was accessed from the North Central study site of the REmoving the MAsk on Hypertension (REMAH) study. Homocysteine, blood glucose and lipid profile in whole blood/serum were measured using standard laboratory methods. Hypertension was diagnosed if average of 5 consecutive blood pressure (BP) measurements obtained using a mercury sphygmomanometer was equal to or higher than 140 systolic and/or 90 mmHg diastolic or the individual is on antihypertensive medication. Hyperhomocysteinemia (HHcy) was defined as Hcy > 10 µmol/L.ResultsOf the 156 participants, 72 (43.5%) were hypertensive, of whom 18 had HHcy. Subjects with HHcy were significantly (p < 0.05) older (41.5 vs. 40.6yrs), had lower HDL-cholesterol (0.6 vs. 0.8 mmol/L) and higher systolic (145.5 vs. 126.0 mmHg) and diastolic BP (92.9 vs. 79.6 mmHg), compared to those without HHcy. Intake of alcohol and a 1 yr increase in age were respectively and significantly (p < 0.05) associated with a 1.54 and 0.10 µmol/L increase in Hcy. In a multivariable model adjusted for age, sex and body mass index, a 1 µmol/L increase in Hcy, was associated with a 1.69 mmHg and 1.34 mmHg increase in systolic and diastolic pressure (p < 0.0001) respectively; and a 0.01 mmol/L decrease in HDL-cholesterol (p < 0.05).ConclusionHHcy occurs among hypertensive Nigerians and it is independently associated with age, HDL-cholesterol, systolic and diastolic BP.
Morphological and genetic heterogeneity of synchronous multifocal lung adenocarcinoma in a Chinese cohort
Authors: Zhu Donglin , Cao Dan , Shen Minghong , Lv Jinghuan 
Published: February 2021

Abstract
Background
Synchronous multifocal lung cancer (SMLC) is diagnosed with increasing frequency in clinical practice globally. Due to innate variation in clinical management and outcome, it is vital to properly distinguish between synchronous multifocal primary lung cancer (SMPLC) and intrapulmonary metastasis (IM). The pathologic features and principal classification criteria of multifocal lung cancer remain unclear. Our objective was to evaluate the diagnostic value of histological morphologic features and driver gene mutations in SMLC classification.

Methods
We collected a unique cohort of Chinese patients with SMLC, and fully explored the morphologic, immunohistochemical, and molecular features of the disease. Twenty-one SMLC patients with a total of 50 tumours were included in our study. The pathological features that were presented by these patients were analysed, including the tumours location, tumours size, pathological types, predominant pattern of adenocarcinoma, and immunohistochemical staining. We conducted molecular testing of nine driver oncogenes that are associated with lung cancer, namely, EGER, KRAS, BRAF, NRAS, ALK, ROS1, RET, HER2, and PIK3CA.

Results
According to the Martini-Melamed classification and refined standard, 8 and 17 patients, respectively, were considered to have SMPLCs. Gene mutations were identified in 18 tumours (36%). Twelve patients had different gene mutations.

Conclusions
We demonstrate that conventional morphological assessment is not sufficient to clearly establish the clonal relationship of SMPLCs. Instead, the evaluation of histological subtypes, including nonmucinous adherent components, is required. Multiplex genotypic analysis may also prove to be a useful additional tool.