bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
Authors: Fernández de Larrea Carlos , Kyle Robert , Rosiñol Laura , Paiva Bruno , Engelhardt Monika , Usmani Saad , Caers Jo , Gonsalves Wilson , Schjesvold Fredrik , Merlini Giampaolo , Lentzch Suzanne , Ocio Enrique , Garderet Laurent , Moreau Philippe , Sonneveld Pieter , Badros Ashraf , Gahrton Gösta , Goldschmidt Hartmut , Tuchman Sascha , Einsele Hermann , Durie Brian , Wirk Baldeep , Musto Pellegrino , Hayden Patrick , Kaiser Martin , Miguel Jesús San , Bladé Joan , Rajkumar S. Vincent , Mateos Maria Victoria 
Published: December 2021

AbstractPrimary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of multiple myeloma. We could identify two retrospective series where the question about what number of circulating plasma cells in peripheral blood should be used for defining PCL. The presence of ≥5% circulating plasma cells in patients with MM had a similar adverse prognostic impact as the previously defined PCL. Therefore, PCL should be defined by the presence of 5% or more circulating plasma cells in peripheral blood smears in patients otherwise diagnosed with symptomatic multiple myeloma.
Hypotensive effect of captopril on deoxycorticosterone acetate-salt-induced hypertensive rat is associated with gut microbiota alteration
Authors: Wu Haicui , Lam Theo Y. C. , Shum Tim-Fat , Tsai Tsung-Yu , Chiou Jiachi 
Published: December 2021

AbstractThe role of the gut microbiota in various metabolic diseases has been widely studied. This study aims to test the hypothesis that gut microbiota dysbiosis is associated with DOCA-salt-induced hypertension, while captopril, an antihypertensive drug, is able to rebalance the gut microbiota alterations caused by hypertension. Treatment with captopril resulted in an approximate 32 mmHg reduction in systolic blood pressure (162.57 vs. 194.61 mmHg) in DOCA-salt-induced hypertensive rats, although it was significantly higher than that in SHAM rats (136.10 mmHg). Moreover, the nitric oxide (NO) level was significantly increased (20.60 vs. 6.42 µM) while the angiotensin II (Ang II) content (42.40 vs. 59.47 pg/ml) was attenuated nonsignificantly by captopril treatment in comparison to those of DOCA-salt-induced hypertensive rats. The introduction of captopril significantly decreased the levels of tumor necrosis factor-α (TNF-ɑ) and interleukin-6 (IL-6). Hypertrophy and fibrosis in kidneys and hearts were also significantly attenuated by captopril. Furthermore, gut microbiota dysbiosis was observed in DOCA-salt-induced hypertensive rats. The abundances of several phyla and genera, including Proteobacteria, Cyanobacteria,Escherichia-Shigella,Eubacterium nodatumandRuminococcus, were higher in DOCA-salt-induced hypertensive rats than in SHAM rats, while these changes were reversed by captopril treatment. Of particular interest, the generaBifidobacteriumandAkkermansia, reported as beneficial bacteria in the gut, were abundant in only hypertensive rats treated with captopril. These results provide evidence that captopril has the potential to rebalance the dysbiotic gut microbiota of DOCA-salt-induced hypertensive rats, suggesting that the alteration of the gut flora by captopril may contribute to the hypotensive effect of this drug.
Observers of quantum systems cannot agree to disagree
Authors: Contreras-Tejada Patricia , Scarpa Giannicola , Kubicki Aleksander M. , Brandenburger Adam , La Mura Pierfrancesco 
Published: December 2021

AbstractIs the world quantum? An active research line in quantum foundations is devoted to exploring what constraints can rule out the postquantum theories that are consistent with experimentally observed results. We explore this question in the context of epistemics, and ask whether agreement between observers can serve as a physical principle that must hold for any theory of the world. Aumann’s seminal Agreement Theorem states that two observers (of classical systems) cannot agree to disagree. We propose an extension of this theorem to no-signaling settings. In particular, we establish an Agreement Theorem for observers of quantum systems, while we construct examples of (postquantum) no-signaling boxes where observers can agree to disagree. The PR box is an extremal instance of this phenomenon. These results make it plausible that agreement between observers might be a physical principle, while they also establish links between the fields of epistemics and quantum information that seem worthy of further exploration.
Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
Authors: Müller Maik , Gräbnitz Fabienne , Barandun Niculò , Shen Yang , Wendt Fabian , Steiner Sebastian N. , Severin Yannik , Vetterli Stefan U. , Mondal Milon , Prudent James R. , Hofmann Raphael , van Oostrum Marc , Sarott Roman C. , Nesvizhskii Alexey I. , Carreira Erick M. , Bode Jeffrey W. , Snijder Berend , Robinson John A. , Loessner Martin J. , Oxenius Annette , Wollscheid Bernd 
Published: December 2021

AbstractThe molecular nanoscale organization of the surfaceome is a fundamental regulator of cellular signaling in health and disease. Technologies for mapping the spatial relationships of cell surface receptors and their extracellular signaling synapses would unlock theranostic opportunities to target protein communities and the possibility to engineer extracellular signaling. Here, we develop an optoproteomic technology termed LUX-MS that enables the targeted elucidation of acute protein interactions on and in between living cells using light-controlled singlet oxygen generators (SOG). By using SOG-coupled antibodies, small molecule drugs, biologics and intact viral particles, we demonstrate the ability of LUX-MS to decode ligand receptor interactions across organisms and to discover surfaceome receptor nanoscale organization with direct implications for drug action. Furthermore, by coupling SOG to antigens we achieved light-controlled molecular mapping of intercellular signaling within functional immune synapses between antigen-presenting cells and CD8+ T cells providing insights into T cell activation with spatiotemporal specificity. LUX-MS based decoding of surfaceome signaling architectures thereby provides a molecular framework for the rational development of theranostic strategies.
Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
Authors: Matsumura Yoshihiro , Ito Ryo , Yajima Ayumu , Yamaguchi Rei , Tanaka Toshiya , Kawamura Takeshi , Magoori Kenta , Abe Yohei , Uchida Aoi , Yoneshiro Takeshi , Hirakawa Hiroyuki , Zhang Ji , Arai Makoto , Yang Chaoran , Yang Ge , Takahashi Hiroki , Fujihashi Hitomi , Nakaki Ryo , Yamamoto Shogo , Ota Satoshi , Tsutsumi Shuichi , Inoue Shin-ichi , Kimura Hiroshi , Wada Youichiro , Kodama Tatsuhiko , Inagaki Takeshi , Osborne Timothy F. , Aburatani Hiroyuki , Node Koichi , Sakai Juro 
Published: December 2021

AbstractEnhancer activation is essential for cell-type specific gene expression during cellular differentiation, however, how enhancers transition from a hypoacetylated “primed” state to a hyperacetylated-active state is incompletely understood. Here, we show SET domain-containing 5 (SETD5) forms a complex with NCoR-HDAC3 co-repressor that prevents histone acetylation of enhancers for two master adipogenic regulatory genesCebpaandPpargearly during adipogenesis. The loss of SETD5 from the complex is followed by enhancer hyperacetylation. SETD5 protein levels were transiently increased and rapidly degraded prior to enhancer activation providing a mechanism for the loss of SETD5 during the transition. We show that induction of the CDC20 co-activator of the ubiquitin ligase leads to APC/C mediated degradation of SETD5 during the transition and this operates as a molecular switch that facilitates adipogenesis.
Theta rhythmicity governs human behavior and hippocampal signals during memory-dependent tasks
Authors: ter Wal Marije , Linde-Domingo Juan , Lifanov Julia , Roux Frédéric , Kolibius Luca D. , Gollwitzer Stephanie , Lang Johannes , Hamer Hajo , Rollings David , Sawlani Vijay , Chelvarajah Ramesh , Staresina Bernhard , Hanslmayr Simon , Wimber Maria 
Published: December 2021

AbstractMemory formation and reinstatement are thought to lock to the hippocampal theta rhythm, predicting that encoding and retrieval processes appear rhythmic themselves. Here, we show that rhythmicity can be observed in behavioral responses from memory tasks, where participants indicate, using button presses, the timing of encoding and recall of cue-object associative memories. We find no evidence for rhythmicity in button presses for visual tasks using the same stimuli, or for questions about already retrieved objects. The oscillations for correctly remembered trials center in the slow theta frequency range (1-5 Hz). Using intracranial EEG recordings, we show that the memory task induces temporally extended phase consistency in hippocampal local field potentials at slow theta frequencies, but significantly more for remembered than forgotten trials, providing a potential mechanistic underpinning for the theta oscillations found in behavioral responses.
Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
Authors: Hildebrandt Franziska , Andersson Alma , Saarenpää Sami , Larsson Ludvig , Van Hul Noémi , Kanatani Sachie , Masek Jan , Ellis Ewa , Barragan Antonio , Mollbrink Annelie , Andersson Emma R. , Lundeberg Joakim , Ankarklev Johan 
Published: December 2021

AbstractReconstruction of heterogeneity through single cell transcriptional profiling has greatly advanced our understanding of the spatial liver transcriptome in recent years. However, global transcriptional differences across lobular units remain elusive in physical space. Here, we apply Spatial Transcriptomics to perform transcriptomic analysis across sectioned liver tissue. We confirm that the heterogeneity in this complex tissue is predominantly determined by lobular zonation. By introducing novel computational approaches, we enable transcriptional gradient measurements between tissue structures, including several lobules in a variety of orientations. Further, our data suggests the presence of previously transcriptionally uncharacterized structures within liver tissue, contributing to the overall spatial heterogeneity of the organ. This study demonstrates how comprehensive spatial transcriptomic technologies can be used to delineate extensive spatial gene expression patterns in the liver, indicating its future impact for studies of liver function, development and regeneration as well as its potential in pre-clinical and clinical pathology.
Mapping the serum proteome to neurological diseases using whole genome sequencing
Authors: Png Grace , Barysenka Andrei , Repetto Linda , Navarro Pau , Shen Xia , Pietzner Maik , Wheeler Eleanor , Wareham Nicholas J. , Langenberg Claudia , Tsafantakis Emmanouil , Karaleftheri Maria , Dedoussis George , Mälarstig Anders , Wilson James F. , Gilly Arthur , Zeggini Eleftheria 
Published: December 2021

AbstractDespite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry out a protein quantitative trait locus analysis of 184 neurologically-relevant proteins, using whole genome sequencing data from two isolated population-based cohorts (N = 2893). In doing so, we elucidate the genetic landscape of the circulating proteome and its connection to neurological disorders. We detect 214 independently-associated variants for 107 proteins, the majority of which (76%) are cis-acting, including 114 variants that have not been previously identified. Using two-sample Mendelian randomisation, we identify causal associations between serum CD33 and Alzheimer’s disease, GPNMB and Parkinson’s disease, and MSR1 and schizophrenia, describing their clinical potential and highlighting drug repurposing opportunities.
Systematic review of pathways to care in the U.S. for Black individuals with early psychosis
Authors: Oluwoye Oladunni , Davis Beshaun , Kuhney Franchesca S. , Anglin Deidre M. 
Published: December 2021

AbstractThe pathway to receiving specialty care for first episode psychosis (FEP) among Black youth in the US has received little attention despite documented challenges that negatively impact engagement in care and clinical outcomes. We conducted a systematic review of US-based research, reporting findings related to the pathway experiences of Black individuals with FEP and their family members. A systematic search of PubMed, PsycInfo, and Embase/Medline was performed with no date restrictions up to April 2021. Included studies had samples with at least 75% Black individuals and/or their family members or explicitly examined racial differences. Of the 80 abstracts screened, 28 peer-reviewed articles met the inclusion criteria. Studies were categorized into three categories: premordid and prodromal phase, help-seeking experiences, and the duration of untreated psychosis (DUP). Compounding factors such as trauma, substance use, and structural barriers that occur during the premorbid and prodromal contribute to delays in treatment initiation and highlight the limited use of services for traumatic childhood experiences (e.g., sexual abuse). Studies focused on help-seeking experiences demonstrated the limited use of mental health services and the potentially traumatic entry to services (e.g., law enforcement), which is associated with a longer DUP. Although the majority of studies focused on help-seeking experiences and predictors of DUP, findings suggests that for Black populations, there is a link between trauma and substance use in the pathway to care that impacts the severity of symptoms, initiation of treatment, and DUP. The present review also identifies the need for more representative studies of Black individuals with FEP.
Study on valuable metal incorporation in the Fe–Al precipitate during neutralization of LIB leach solution
Authors: Chernyaev Alexander , Wilson Benjamin P. , Lundström Mari 
Published: December 2021

AbstractThe role of aluminum concentration and pH in the purification of waste Li-ion battery leach solution was investigated using NaOH and LiOH as neutralization agents ([H2SO4] = 0.313 M, t = 6 h). Solution was prepared from synthetic chemicals to mimic real battery leach solution. Results demonstrate that pH (3.5–5.5) has a significant effect on the precipitation of metals (Fe, Al, Ni, Cu, Co, Mn, and Li), whereas higher temperature (T = 30 and 60 °C) decreases the precipitation pH of metals. Iron and aluminum were both found to precipitate at ca. pH 4 and the presence of aluminum in PLS clearly decreased the separation efficiency of Fe vs. active material metals (Ni, Co, Li). In the absence of dissolved aluminum, Fe precipitated already at pH 3.5 and did not result in the co-precipitation of other metals. Additionally, the Al-free slurry had a superior filtration performance. However, aluminum concentrations of 2 and 4 g/L were found to cause loss of Ni (2–10%), Co (1–2%) and Li (2–10%) to the Fe-Al hydroxide cake at pH 4. The use of LiOH (vs. NaOH) resulted in 50% lower co-precipitation of Ni, Co and Li. Overall, these results demonstrate that hydroxide precipitation can be an effective method to remove iron from battery waste leach solutions at aluminum concentrations of < 2 g/L only. Although the highest level of lithium loss in the cake was found at pH 4, the loss was shown to decrease with increasing pH.
Modelling ocean acidification effects with life stage-specific responses alters spatiotemporal patterns of catch and revenues of American lobster, Homarus americanus
Authors: Tai Travis C. , Calosi Piero , Gurney-Smith Helen J. , Cheung William W. L. 
Published: December 2021

AbstractOcean acidification (OA) affects marine organisms through various physiological and biological processes, yet our understanding of how these translate to large-scale population effects remains limited. Here, we integrated laboratory-based experimental results on the life history and physiological responses to OA of the American lobster, Homarus americanus, into a dynamic bioclimatic envelope model to project future climate change effects on species distribution, abundance, and fisheries catch potential. Ocean acidification effects on juvenile stages had the largest stage-specific impacts on the population, while cumulative effects across life stages significantly exerted the greatest impacts, albeit quite minimal. Reducing fishing pressure leads to overall increases in population abundance while setting minimum size limits also results in more higher-priced market-sized lobsters (> 1 lb), and could help mitigate the negative impacts of OA and concurrent stressors (warming, deoxygenation). However, the magnitude of increased effects of climate change overweighs any moderate population gains made by changes in fishing pressure and size limits, reinforcing that reducing greenhouse gas emissions is most pressing and that climate-adaptive fisheries management is necessary as a secondary role to ensure population resiliency. We suggest possible strategies to mitigate impacts by preserving important population demographics.
Multiomics analysis of soybean meal induced marine fish enteritis in juvenile pearl gentian grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂
Authors: Zhang Wei , Tan Beiping , Deng Junming , Haitao Zhang 
Published: December 2021

AbstractAs an important protein source, soybean products can cause intestinal inflammation and injury in many animals including human beings, particularly infants and juvenile individuals. Research in this field has been performed for terrestrial animals and fish, but still lacks integrity and systematicness. In this study, the main biological processes in the intestinal tract of marine fish juvenile pearl gentian grouper in the state of soybean meal-induced enteritis (SBMIE) were analyzed. A total of 720 groupers with an approximate initial weight of 12.5 g were randomly divided into three groups: the fish meal (FM) control group, the 20% SBM group (SBM20), and the SBM40 group (n = 4). Three iso-nitrogenous and iso-lipidic diets were prepared and fed to fish for 10 weeks. Each barrel contained a water volume of about 1 m3 in and was exposed to natural light and temperature. Results indicated that the growth and physiology of groupers fed with SBM were significantly negatively affected, with the gene expressions of intestinal structural protein abnormal. 16SrDNA high-throughput sequencing showed that the intestinal microflora played an important role in the pathogenesis of pearl gentian grouper SBMIE, which may activate a variety of pathogen pattern recognition receptors, such as toll-like receptors (TLRs), RIG-I-like receptors, and nod-like receptors. Transcriptome analysis revealed that changes of the SBMIE signaling pathway in pearl gentian groupers were conservative to some extent than that of terrestrial animals and freshwater fish. Moreover, the TLRs-nuclear factor kappa-B signaling pathway becomes activated, which played an important role in SBMIE. Meanwhile, the signal pathways related to nutrient absorption and metabolism were generally inhibited. Metabolomics analysis showed that isoflavones and saponins accounted for a large proportion in the potential biomarkers of pearl gentian grouper SBMIE, and most of the biomarkers had significantly positive or negative correlations with each other; 56 metabolites were exchanged between intestinal tissues and contents, which may play an important role in the development of enteritis, including unsaturated fatty acids, organic acids, amino acids, vitamins, small peptides, and nucleotides, etc. These results provide a basic theoretical reference for solving the intestinal issues of fish SBMIE and research of inflammatory bowel disease in mammals.
Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
Authors: Morgan Catherine A. , Melzer Tracy R. , Roberts Reece P. , Wiebels Kristina , Mutsaerts Henk J. M. M. , Spriggs Meg J. , Dalrymple-Alford John C. , Anderson Tim J. , Cutfield Nicholas J. , Deib Gerard , Pfeuffer Josef , Addis Donna Rose , Kirk Ian J. , Tippett Lynette J. 
Published: December 2021

AbstractCerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps as a surrogate for ATT, in volunteers meeting criteria for subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI) and probable Alzheimer’s dementia (AD). Whole-brain pseudo continuous ASL MRI was performed at 3 T in 122 participants (controls = 20, SCD = 44, MCI = 45 and AD = 13) across three sites in New Zealand. From CBF maps that included all grey matter, sCoV progressively increased across each group with increased cognitive deficit. A similar overall trend was found when examining sCoV solely in the temporal lobe. We conclude that sCoV, a simple to compute imaging metric derived from ASL MRI, is sensitive to varying degrees of cognitive changes and supports the view that vascular health contributes to cognitive decline associated with Alzheimer’s disease.