bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term effects and cost-benefit analysis of eight spawning gravel augmentations for Atlantic salmon and Brown trout in Norway
Authors: Pulg Ulrich , Lennox Robert J. , Stranzl Sebastian , Espedal Espen O. , Gabrielsen Sven Erik , Wiers Tore , Velle Gaute , Hauer Christoph , Dønnum Bjørn Otto , Barlaup Bjørn T. 
Published: August 2021

AbstractRiver regulation alters flow and sediment regime, habitat availability, and ultimately the ecological functioning of rivers. Various restoration and mitigation measures have been developed to improve ecological function, and among them is the addition of gravel to enhance the reproduction of gravel bed spawning fishes. However, information on long-term efficiency, costs, and maintenance needs of gravel additions are scarce. Here, we study the functioning of gravel additions at eight sites in three rivers in western Norway for up to 18 years. Gravel was added between 2002 and 2010 to enhance spawning of Atlantic salmon and anadromous Brown trout. We monitored changes in the size of the gravel-covered areas, sediment composition, interstitial oxygen, egg survival, and juvenile fish densities. Additionally, we report monetary costs, identify potential maintenance needs, and calculate a cost-benefit ratio. Juvenile densities of Atlantic salmon and Brown trout increased significantly after the gravel augmentations. After 10–18 years, the median egg survival was still high (> 90%) and sediment conditions were still suitable for salmonid fish reproduction. The areas were, however, shrinking across time (median area reduction 26%), mostly caused by scouring of gravel in the steep, supply-limited, and partly regulated rivers. The average construction costs of spawning gravel augmentations were 11.2 NOK (1.12 €) m−2year−1. Compared to similar measures elsewhere, the measures have had a long life span (up to 18 years) at relatively low costs. Gravel augmentation was concluded to be a successful management measure that contributed to significantly increased Atlantic salmon and Brown trout reproduction.
Comparative study on the influence of surface characteristics on de-icing evaluation
Authors: Memon Halar , Mirshahidi Kiana , Zarasvand Kamran Alasvand , Golovin Kevin , De Focatiis Davide S. A. , Choi Kwing-So , Hou Xianghui 
Published: August 2021

AbstractA comparative study of de-icing evaluation methods was conducted in this work, and their variations in response to surface characteristics were investigated. The mechanical de-icing measurements include centrifugal, push, and tensile methods. The centrifugal and the horizontal push (shear) methods suggested a linear relationship of ice adhesion strength with surface roughness, whereas the tensile (normal) method indicated an inverse curvilinear relationship with contact angle hysteresis. A partial correlation of contact angle hysteresis on the shear-based methods was also indicated over a specified range of surface roughness. Further attempts were also made on 1H,1H,2H,2H-perfluorooctyltriethoxysilane-coated surfaces, and the ice adhesion indicated a clear reduction in the normal de-icing method, whereas the shear-based methods did not show a considerable change in ice adhesion, highlighting their mechanical forces-centric response. Lastly, a further evaluation using a hybrid de-icing method was conducted, to verify the influence of surface characteristics on ice removal involving heating, which demonstrated a partial correlation of energy consumption with the ice adhesion strength over a specified range of surface roughness. The results obtained in this study provide crucial information on the influence of surface characteristics on ice adhesion and offer material-dependent correlations of the popular de-icing evaluation methods. The conclusions could be applied to define an appropriate testing method for the evaluation of icephobic surfaces and coatings.

Graphical abstract
Quercetin modified electrospun PHBV fibrous scaffold enhances cartilage regeneration
Authors: Chen Wei , Li Yongsheng , Huang Yuting , Dai Yao , Xi Tingfei , Zhou Zheng , Liu Hairong 
Published: August 2021

AbstractIt suggests that the poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) scaffold can be used for cartilage tissue engineering, but PHBV is short of bioactivity that is required for cartilage regeneration. To fabricate a bioactive cartilage tissue engineering scaffold that promotes cartilage regeneration, quercetin (QUE) modified PHBV (PHBV-g-QUE) fibrous scaffolds were prepared by a two-step surface modification method. The PHBV-g-QUE fibrous scaffold facilitates the growth of chondrocytes and maintains chondrocytic phenotype resulting from the upregulation of SOX9, COL II, and ACAN. The PHBV-g-QUE fibrous scaffold inhibited apoptosis of chondrocyte and reduced oxidative stress of chondrocytes by regulating the transcription of related genes. Following PHBV-g-QUE fibrous scaffolds and PHBV fibrous scaffolds with adhered chondrocytes were implanted into nude mice for 4 weeks, it demonstrated that PHBV-g-QUE fibrous scaffolds significantly promoted cartilage regeneration compared with the PHBV fibrous scaffolds. Hence, it suggests that the PHBV-g-QUE fibrous scaffold can be potentially applied in the clinical treatment of cartilage defects in the future.
Mammary Development and Breast Cancer: a Notch Perspective
Authors: Chen Weizhen , Wei Wei , Yu Liya , Ye Zi , Huang Fujing , Zhang Liyan , Hu Shiqi , Cai Cheguo 
Published: August 2021

AbstractMammary gland development primarily occurs postnatally, and this unique process is complex and regulated by systemic hormones and local growth factors. The mammary gland is also a highly dynamic organ that undergoes profound changes at puberty and during the reproductive cycle. These changes are driven by mammary stem cells (MaSCs). Breast cancer is one of the most common causes of cancer-related death in women. Cancer stem cells (CSCs) play prominent roles in tumor initiation, drug resistance, tumor recurrence, and metastasis. The highly conserved Notch signaling pathway functions as a key regulator of the niche mediating mammary organogenesis and breast neoplasia. In this review, we discuss mechanisms by which Notch contributes to breast carcinoma pathology and suggest potentials for therapeutic targeting of Notch in breast cancer. In summary, we provide a comprehensive overview of Notch functions in regulating MaSCs, mammary development, and breast cancer.
Qualitative properties and relations
Authors: Plate Jan 
Published: August 2021

AbstractThis paper is concerned with two concepts of qualitativeness that apply to intensional entities (i.e., properties, relations, and states of affairs). I propose an account ofpurequalitativeness that largely follows the traditional understanding established by Carnap, and try to shed light on its ontological presuppositions. On this account, an intensional entity is purely qualitative iff it does not ‘involve’ any particular (i.e., anything that is not an intensional entity). An alternative notion of qualitativeness—which I propose to refer to as a concept ofstrictqualitativeness—has recently been introduced by Chad Carmichael. However, Carmichael’s definition presupposes a highly fine-grained conception of properties and relations. To eliminate this presupposition, I tentatively suggest a different definition that rests on a concept ofperspicuous denotation. In the penultimate section, both concepts of qualitativeness are put to work in distinguishing between different ‘grades’ of qualitative discriminability.
Genealogical Solutions to the Problem of Critical Distance: Political Theory, Contextualism and the case of Punishment in Transitional Scenarios
Authors: Testini Francesco 
Published: August 2021

AbstractIn this paper, I argue that one approach to normative political theory, namely contextualism, can benefit from a specific kind of historical inquiry, namely genealogy, because the latter provides a solution to a deep-seated problem for the former. This problem consists in a lack of critical distance and originates from the justificatory role that contextualist approaches attribute to contextual facts. I compare two approaches to genealogical reconstruction, namely the historiographical method pioneered by Foucault and the hybrid method of pragmatic genealogy as practiced by Bernard Williams, arguing that they both ensure an increase in critical distance while preserving contextualism’s distinctiveness. I also show, however, that only the latter provides normative action-guidance and can thus assist the contextualist theorist in the crucial task of discerning how far certain contextual facts deserve their justificatory role. I prove this point by showing how a pragmatic genealogy of the practice of punishment can inform the contextualist’s reflection about the role this practice should play in a transitional scenario, i.e. in the set of circumstances societies go through in the aftermath of large-scale violence and human rights violations.
Bayesian inference for continuous-time hidden Markov models with an unknown number of states
Authors: Luo Yu , Stephens David A. 
Published: August 2021

AbstractWe consider the modeling of data generated by a latent continuous-time Markov jump process with a state space of finite but unknown dimensions. Typically in such models, the number of states has to be pre-specified, and Bayesian inference for a fixed number of states has not been studied until recently. In addition, although approaches to address the problem for discrete-time models have been developed, no method has been successfully implemented for the continuous-time case. We focus on reversible jump Markov chain Monte Carlo which allows the trans-dimensional move among different numbers of states in order to perform Bayesian inference for the unknown number of states. Specifically, we propose an efficient split-combine move which can facilitate the exploration of the parameter space, and demonstrate that it can be implemented effectively at scale. Subsequently, we extend this algorithm to the context of model-based clustering, allowing numbers of states and clusters both determined during the analysis. The model formulation, inference methodology, and associated algorithm are illustrated by simulation studies. Finally, we apply this method to real data from a Canadian healthcare system in Quebec.
Associations Between Industry Payments to Physicians for Antiplatelet Drugs and Utilization of Cardiac Procedures and Stents
Authors: Yanagisawa Mao , Blumenthal Daniel M. , Kato Hirotaka , Inoue Kosuke , Tsugawa Yusuke 
Published: August 2021

Abstract
Background
A study has shown that industry payments to physicians for drugs are associated not only with higher drug prescriptions but also with higher non-drug costs due to additional utilization of healthcare services. However, the association between industry payments to cardiologists for antiplatelet drugs and the costs and number of percutaneous coronary interventions they perform has not been investigated.

Objective
To examine the association between industry payments to cardiologists for antiplatelet drugs and the costs and number of percutaneous coronary interventions they perform.

Design
Using the 2016 Open Payments Database linked to the 2017 Medicare Provider Utilization and Payment Data, we examined the association between the value of industry payments related to the antiplatelet drugs prasugrel and ticagrelor and healthcare spending and volume for cardiovascular procedures, adjusted for potential cofounders.

Subjects
A total of 7456 cardiologists who performed diagnostic cardiac catheterizations on Medicare beneficiaries in 2017.

Main Measures
Primary outcomes included (1) healthcare spending on cardiac procedures, (2) diagnostic cardiac catheterization volumes, and (3) rates of coronary stenting. Secondary outcomes were total expenditures for all drugs and for antiplatelet drugs.

Key Results
Industry payments for antiplatelet drugs were associated with higher healthcare spending on cardiac procedures (adjusted difference, +$50.9 for additional $100 industry payments; 95% CI, +$25.5 to +$76.2; P < 0.001), diagnostic cardiac catheterizations (+0.1 procedures per cardiologist; 95% CI, +0.03 to +0.1; P=0.001), and stent use (+0.5 per 1000 diagnostic cardiac catheterizations per cardiologist; 95% CI, +0.2 to +0.9; P=0.002). Industry payments for antiplatelet drugs were associated with higher total costs for all drugs and antiplatelet drugs.

Conclusions
Industry payments to cardiologists for antiplatelet drugs were associated with both prescribing of antiplatelet drugs and the use of cardiac procedures and stents. Further research is warranted to understand whether the observed associations are causal or reflect a greater propensity for higher volume proceduralists to have relationships with industry.
Störungen als Ressource
Authors: Tschira Antje 
Published: August 2021

ZusammenfassungDer folgende Beitrag der Zeitschrift Gruppe. Interaktion. Organisation (GIO) befasst sich mit dem Potenzial, das Störungen und Konflikte für das Überleben der Organisationen entfalten können und damit, warum es für ein gelingendes Change Management aus konstruktivistischer und gruppendynamischer Sicht geradezu ein Gebot ist, dieses zu heben. Eine Möglichkeit der methodischen Umsetzung wird exemplarisch an dem Format einer Dynamischen Soziogrammaufstellung veranschaulicht, welche das methodische Herzstück eines Veränderungsprozesses an einer Schule bildete.
‘The medical gaze’: Foucault, anthropology and contemporary psychiatry in Ireland
Authors: O’Callaghan Aoife K 
Published: August 2021

AbstractMichel Foucault developed the concept of ‘the medical gaze’, describing how doctors fit a patient’s story into a ‘biomedical paradigm, filtering out what is deemed as irrelevant material’ (Misselbrook, 2013). Doctors are perceived within this model to focus on selecting the biomedical elements of patients’ problems only, filtering out all other elements of a person’s life story, but this paper argues that in the subspecialty of psychiatry, this is not the case, and such a filter is not so easily applied.
Stiffening in the carpus of Prosantorhinus germanicus (Perissodactyla, Rhinocerotidae) from Sandelzhausen (Germany)
Authors: Schellhorn Rico 
Published: August 2021

AbstractProsantorhinusgermanicusis a small, short-legged, teleoceratine rhino from the Miocene of Sandelzhausen (Bavaria, Germany).P.germanicusshows a high variation in some of its carpal bones. A unique modification of the articulation of Intermedium and Carpale 4 is described here. Special emphasis is given to additional articulation facets at the palmar processes of both bones. These additional contacts, working as stop facets, are unique among rhinos and restrict the flexion of the mid-carpal joint. Some individuals show these additional facets which prohibit the flexion within the wrist and therefore stiffen the carpus. Carpale 4 specimens without the additional facets show knob-like structures instead. These knobs are most likely precursory structures of those facets and the facets are fully developed in heavier males. A skeletal sexual dimorphism is not visible in the sample as all bones are in the same size range. The wrist stiffening in the mid-carpal joint supports a greater bodyweight and therefore could coincide withP.germanicusas a proposed dwarfed rhinoceros species. The stiffening can also be interpreted in favor of a semiaquatic mode of life. The stiffened carpus is more resistant against injuries while walking on muddy grounds in a wet environment.
The Use of Corticosteroids for Cardiopulmonary Bypass in Adults
Authors: Perchermeier Sophie , Tassani-Prell Peter 
Published: August 2021

AbstractPurpose of ReviewCardiopulmonary bypass for on-pump cardiac surgery induces a systemic inflammation that may contribute to postoperative major complications. To reduce this inflammatory response in patients undergoing heart surgery, the perioperative use of anti-inflammatory corticosteroids has long been recommended to improve clinical outcomes. However, the efficacy and safety of steroids remain still unclear.Recent FindingsWe reviewed recent published literature, including the large clinical trials DECS and SIRS and the two meta-analysis by Dvirnik et al. (2018) and Ng et al. (2020), on mortality and major postoperative complications, such as myocardial complications, atrial fibrillation, stroke, pulmonary adverse events, length of ICU and hospital stay, renal failure, and infection.SummaryThe perioperative application of corticosteroids did not improve mortality rates beyond standard care or other secondary outcomes, such as myocardial infarction, stroke, renal failure, and infection. The observed increased risk of myocardial damage in patients receiving corticosteroids in the SIRS trial is mainly related to the author-defined CK-MB threshold as indicator for early myocardial injury. Interestingly, the use of steroids may have some beneficial effects on secondary outcomes: they significantly decreased the risk of respiratory failure and pneumonia and shortened the length of ICU and hospital stay, but the mechanism involved in pulmonary injury is multifactorial and it is difficult to evaluate this result. Patients receiving steroids did not have a decreased incidence of atrial fibrillation shown by the two large trials unlike some previous small sample size trials have demonstrated.
Inter-specific competition among trees in pythagorean fuzzy soft environment
Authors: Akram Muhammad , Nawaz Hafiza Saba 
Published: August 2021

AbstractA Pythagorean fuzzy set is very effective mathematical framework to represent parameter-wise imprecision which is the property of linguistic communication. A Pythagorean fuzzy soft graph is more potent than the intuitionistic fuzzy soft as well as the fuzzy soft graph as it depicts the interactions among the objects of a system using Pythagorean membership grades with respect to different parameters. This article addresses the content of competition graphs as well as economic competition graphs like k-competition graphs, m-step competition graphs and p-competition graphs in Pythagorean fuzzy soft environment. All these concepts are illustrated with examples and fascinating results. Furthermore, an application which describes the competition among distinct forest trees, that grow together in the mixed conifer forests of California, for plant resources is elaborated graphically. An algorithm is also designed for the construction of Pythagorean fuzzy soft competition graphs. It is worthwhile to express the competing and non-competing interactions in various networks with the help of Pythagorean fuzzy soft competition graphs wherein a variation in competition relative to different attributes is visible.
Tip- and Laser-based 3D Nanofabrication in Extended Macroscopic Working Areas
Authors: Ortlepp Ingo , Fröhlich Thomas , Füßl Roland , Reger Johann , Schäffel Christoph , Sinzinger Stefan , Strehle Steffen , Theska René , Zentner Lena , Zöllner Jens-Peter , Rangelow Ivo W. , Reinhardt Carsten , Hausotte Tino , Cao Xinrui , Dannberg Oliver , Fern Florian , Fischer David , Gorges Stephan , Hofmann Martin , Kirchner Johannes , Meister Andreas , Sasiuk Taras , Schienbein Ralf , Supreeti Shraddha , Mohr-Weidenfeller Laura , Weise Christoph , Reuter Christoph , Stauffenberg Jaqueline , Manske Eberhard 
Published: August 2021

AbstractThe field of optical lithography is subject to intense research and has gained enormous improvement. However, the effort necessary for creating structures at the size of 20 nm and below is considerable using conventional technologies. This effort and the resulting financial requirements can only be tackled by few global companies and thus a paradigm change for the semiconductor industry is conceivable: custom design and solutions for specific applications will dominate future development (Fritze in: Panning EM, Liddle JA (eds) Novel patterning technologies. International society for optics and photonics. SPIE, Bellingham, 2021. 10.1117/12.2593229). For this reason, new aspects arise for future lithography, which is why enormous effort has been directed to the development of alternative fabrication technologies. Yet, the technologies emerging from this process, which are promising for coping with the current resolution and accuracy challenges, are only demonstrated as a proof-of-concept on a lab scale of several square micrometers. Such scale is not adequate for the requirements of modern lithography; therefore, there is the need for new and alternative cross-scale solutions to further advance the possibilities of unconventional nanotechnologies. Similar challenges arise because of the technical progress in various other fields, realizing new and unique functionalities based on nanoscale effects, e.g., in nanophotonics, quantum computing, energy harvesting, and life sciences. Experimental platforms for basic research in the field of scale-spanning nanomeasuring and nanofabrication are necessary for these tasks, which are available at the Technische Universität Ilmenau in the form of nanopositioning and nanomeasuring (NPM) machines. With this equipment, the limits of technical structurability are explored for high-performance tip-based and laser-based processes for enabling real 3D nanofabrication with the highest precision in an adequate working range of several thousand cubic millimeters.
An alternative approach to the tribological analysis of Si-doped DLC coatings deposited with different bias voltages using Raman spectroscopy mapping
Authors: Rodriguez Bruno J. , Navabpour Parnia , Proprentner Daniela , Walker Marc , Sun Hailin , Schiller Tara L. 
Published: August 2021

AbstractA series of diamond-like carbon (DLC) coatings were deposited with increasing bias voltage using magnetron sputtering techniques. Structural changes were observed in the sp2-configuration across the films which were accompanied by a slight increase in the sp3 fraction. With an increasing bias voltage, the thermal stability of the coatings increased from 300 to 450 °C. Oxygen diffusion was observed through the coating as a result of the high-temperature annealing and found to slow down with increasing bias voltage. Coefficients of friction (COF) remained stable with temperature for the individual coatings, with the softer films reporting the lowest COF. Our approach employed Raman spectroscopy to map the wear tracks at different temperatures, providing a deeper understanding of the coating performance and suggested maximum flash temperatures endured during testing.