bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rebound and overshoot of donor‐specific antibodies to human leukocyte antigens (HLA) during desensitization with plasma exchanges in hematopoietic progenitor cell transplantation: A case report
Authors: Hassan Sajjad , West Kamille A. , Ward William W. , Kanakry Jennifer A. , Flegel Willy A. 
Published: April 2021

AbstractBackgroundDonor‐specific antibodies (DSA) to HLA have been associated with graft loss in hematopoietic progenitor cell (HPC) transplantation. Limited data associate therapeutic plasma exchange (TPE) with desensitization and successful engraftment. We report an attempt of desensitization and observed overshooting of DSA during transplantation.Case report and resultsA 27‐year‐old female with cutaneous T cell lymphoma was scheduled for HPC transplantation from her HLA‐haploidentical half‐sister, who carried the HLA‐DRB1*13:03:01 allele. The patient had the corresponding DSA. Lacking an alternative donor option at the time, we attempted a desensitization approach by immunosuppression with tacrolimus and mycophenolate mofetil (MMF). Unexpectedly, DSA increased from a mean fluorescence intensity (MFI) of 1835 on day −63 to 9008 on day −7. The MFI increased further during 3 TPE procedures and intravenous immunoglobulin (IVIG) until day −1. After transplantation, the DSA remained elevated despite 2 more TPE/IVIG procedures and graft‐versus‐host disease prophylaxis with high‐dose cyclophosphamide, sirolimus, and MMF. Flow cytometric crossmatch, initially negative, turned positive after transplantation. Primary graft failure occurred and was attributed to antibody‐mediated rejection. A second transplantation from a 7/8 HLA‐matched unrelated donor, not carrying DRB1*13:03 allele, resulted in successful engraftment.ConclusionUnexpected and rapid increases of a DSA can occur despite the use of current desensitization approaches. This is problematic when conditioning has already started, as such increases are unlikely to be overcome by TPE or other interventions for desensitization. Overshoot of DSA in HPC transplantation has rarely been reported. Its cause remains unclear and can include underlying disease, immunotherapy, chemotherapy, or TPE.
Transfusion burden following reduced intensity allogeneic hematopoietic cell transplantation: Impact of donor type
Authors: Subramanian Sitalakshmi , Cohn Claudia , DeFor Todd , Welbig Julie , Brunstein Claudio , El Jurdi Najla , Weisdorf Daniel 
Published: April 2021

AbstractBackgroundTransfusions are essential for allogeneic hematopoietic cell transplant (HCT), yet they are influenced by graft, donor, and other factors.Study designWe analyzed transfusions in 165 adult reduced intensity HCTs (2016–2019): HLA matched sibling donor (MSD) (n = 59), matched URD (n = 25), UCB (n = 33), and haploidentical (haplo, n = 48) detailing the cumulative incidence of platelet and RBC transfusion independence, total transfusions (day−10 to day+100) plus transfusion densities (per week) over 110 days.ResultsPlatelet recovery to 20 × 109/L by 6 months occurred in 39/48 (81.25%) haplo recipients (median 33 [range, 0–139]) days vs. 58/59 (98.3%) MSD (median 10 [0–37]), 21/25 (84%) matched URD (median 20 [0–153]), and 29/33 (87.87%) UCB (median 48 [29–166]) days, p < .01. Regression analysis demonstrated a lower likelihood of prompt platelet recovery in matched URD, UCB, or haplo HCTs vs. MSD.Recovery to platelet independence was quickest in MSD (median 8 days [range 0–94]), vs. URD (median 16 days [0–99]), UCB (median 57 [0–94]), or haplo (median 45 [12–97]) days, p < .01. Platelet needs were unaffected by age, conditioning, or acute GVHD.RBC transfusion independence was achieved in 78% of MSD, 64% URD, and 82% UCB, though less frequent (58%) and slowest in haplo recipients, p < .01. All haplo and UCB recipients required platelet transfusions vs. only 51% of MSD and 76% of URD. RBC needs were highest in UCB and haplo HCTs.DiscussionThe transplant donor influences the transfusion burden with greater platelet and RBC needs in haplo and UCB HCT which directly contributes to increased cost of care.
West Nile virus and blood transfusion safety: A European perspective
Authors: Garzon Jimenez Rossana C. , Lieshout‐Krikke Ryanne W. , Janssen Mart P. 
Published: April 2021

Background and ObjectivesThere is a growing concern for the transmission of arboviral infections by blood transfusion in Europe. However, no assessment of the risk of transmission through all European blood supplies has been reported. Risk regulations at a European level should take differences in local transmission risk and the risk of transmission by travelling donors into consideration.Materials and MethodsA risk model and publicly available tool were developed to calculate the risk of transmission by all European blood supplies for arboviral outbreaks within Europe. Data on individual European blood supplies from Council of Europe reports and inter‐European travel data from EUROSTAT were used to populate this model.ResultsEach neuroinvasive case of WNV reported in Europe will on average result in 0·43 (95%CI: 0·32–0·55) infected blood product by locally infected donors and 0·010 (95%CI: 0·006–0·015) infected products by travelling donors. On basis of the 1373 neuroinvasive human WNV cases reported in the outbreak of 2018, it is estimated that without safety interventions this outbreak would have resulted in 708 (95%CI: 523–922) infected components derived from resident donors. Noncompliance to European regulations, which requires donor deferral or testing of donors who visited WNV‐infected areas, would have resulted in 7.4 (95%CI: 4·7–11·1) infected blood components derived from infectious travelling donors exposed in outbreak areas throughout Europe.ConclusionThe risk of WNV transmission by a local outbreak is on average 113 times (95%CI: 95–139), so two orders of magnitude higher than the risk of transmission by travelling donors in Europe.
A newly discovered Late Cretaceous metamorphic belt along the active continental margin of the Neo-Tethys ocean
Authors: Wang Dan , Liu Fu-Lai , Palin Richard , Wang Jia-Min , Wolf Mathias , Ji Lei , Wang Fang 
Published: April 2021

Abstract
High-grade metamorphic rocks and crustal melts provide crucial evidence for growth and differentiation of the continental crust, and are widespread in collisional orogens. However, their importance in the evolution of continental arcs remains poorly understood. Metamorphism and related anatexis in the preserved continental margin of the Neo-Tethys ocean serves as a key natural laboratory to investigate this process. Along the Neo-Tethyan arc margin, the Gaoligong shear zone, Yunnan region of China, is an important locality for linking Lhasa in the north with Sibumasu and Burma in the south. Here, Late Cretaceous granulite-facies metamorphism and crustal anatexis have been identified for the first time in the Gaoligong area. Zircon and monazite U-Pb dating indicates that S-type granites formed at 87–73 Ma, granites and buried pelitic sediments were simultaneously metamorphosed at 75–70 Ma during Neo-Tethyan subduction, and all lithologies were overprinted by a younger 40–30 Ma magmatic and strike-slip event related to India-Asia collision. Phase equilibria modeling of high-grade anatectic gneiss in the MnO-Na2O-CaO-K2O-FeO-MgO-Al2O3-SiO2-H2O-TiO2 system indicates peak pressure-temperature (P–T) conditions of 780–800 °C and 6.5–7.5 kbar and defines a cooling and decompressional P–T path for the metapelites. This demonstrates that sediments within the Neo-Tethyan active continental arc were buried to &gt;20 km depth at 75–70 Ma. In combination with the metamorphic record of the Lhasa, Burma, and Sibumasu blocks, an extensive Late Cretaceous metamorphic belt must have formed along the Neo-Tethyan subduction zone. This spatially correlates with coeval gabbro-diorite suites exposed in the Gangdese, Sibumasu and Burma terranes that were triggered by thinning of the lithospheric mantle. This prolonged Late Cretaceous mantle-derived magmatism and lithospheric thinning may have provided a regional-scale heat source for high-grade metamorphism and crustal anatexis along the active continental margin of the Neo-Tethys ocean.
Effectiveness of a workplace intervention reducing psychosocial stressors at work on blood pressure and hypertension
Authors: Trudel Xavier , Gilbert-Ouimet Mahée , Vézina Michel , Talbot Denis , Mâsse Benoît , Milot Alain , Brisson Chantal 
Published: April 2021

ObjectivesTo assess the effectiveness of a workplace intervention reducing psychosocial stressors at work in lowering blood pressure and hypertension prevalence.MethodsThe study design was a quasi-experimental pre–post study with an intervention group and a control group. Post-intervention measurements were collected 6 and 36 months after the midpoint of the intervention. Participants were all white-collar workers employed in three public organisations. At baseline, the intervention and the control groups were composed of 1088 and 1068 workers, respectively. The intervention was designed to reduce psychosocial stressors at work by implementing organisational changes. Adjusted changes in ambulatory blood pressure and hypertension prevalence were examined.ResultsBlood pressure and hypertension significantly decreased in the intervention group while no change was observed in the control group. The differential decrease in systolic blood pressure between the intervention and the control group was 2.0 mm Hg (95% CI: −3.0 to –1.0). The prevalence of hypertension decreased in the intervention group, when compared with the control group (prevalence ratio: 0.85 (95% CI: 0.74 to 0.98)).ConclusionsFindings suggest that psychosocial stressors at work are relevant targets for the primary prevention of hypertension. At the population level, systolic blood pressure reductions such as those observed in the present study could prevent a significant number of premature deaths and disabling strokes.
Boosting positive mood in medical and emergency personnel during the COVID-19 pandemic: preliminary evidence of efficacy, feasibility and acceptability of a novel online ambulatory intervention
Authors: Coifman Karin G. , Disabato David D , Seah T H Stanley , Ostrowski-Delahanty Sarah , Palmieri Patrick A , Delahanty Douglas L. , Gunstad John 
Published: April 2021

ObjectivesThe aim of this project was to test the efficacy of a brief and novel online ambulatory intervention aimed at supporting psychological health and well-being for medical personnel and first responders during the COVID-19 pandemic.MethodsInterested participants, n=28, actively employed as medical personnel, support staff and emergency responders, in the Midwestern USA in May–June of 2020, provided informed consent and were randomised to complete either low-dose or high-dose intervention, one time daily for 1 week via smartphone application. Each daily intervention included expressive writing, adaptive emotion regulation activity and (one vs two) positive emotion-generation activities, lasting 3–6 min a day. Ratings of negative and positive emotion were provided before and after each activity daily. Analyses tested compliance, acceptability, as well as efficacy at increasing positive emotion and decreasing negative emotion with each use and across time.ResultsThe results indicated a 13% increase in positive emotion, t(25)=2.01, p=0.056; and decrease in negative emotion by 44%, t(25)=−4.00, p=0.001 across both doses. However, there was a clear advantage for individuals in the high-dose condition as daily boosts in positive emotion were significantly greater (an additional 9.4%) B=0.47, p=0.018. Overall, compliance was good. Acceptability ratings were good for those who completed the follow-up assessment.ConclusionFront-line personnel, including medical staff and emergency responders, are experiencing unprecedented psychological stress during the COVID-19 pandemic. This investigation suggests both feasibility and efficacy for a brief, daily, ambulatory intervention which could provide essential psychological support to individuals at risk in the workplace.
Ultrasound-guided regional anesthesia: feasibility and effectiveness of teaching via telesimulation in Ethiopia
Authors: Liu Monica , Salmon Margaret , Zaidi Rene , Nagdev Arun , Debebe Finot , Muller Mundenga Furaha , Ruhangaza Cito Furaha , Emiru Haimanot , Belachew Yonas , Tumebo Aklilu , Paoletti Marcus , Okrainec Allan , Chan Vincent , Niazi Ahtsham U 
Published: April 2021

BackgroundAcute pain management in resource-poor countries remains a challenge. Ultrasound-guided regional anesthesia is a cost-effective way of delivering analgesia in these settings. However, for financial and logistical reasons, educational workshops are inaccessible to many physicians in these environments. Telesimulation provides a way of teaching across distance by using simulators and video-conferencing software to connect instructors and students worldwide. We conducted a prospective study to determine the feasibility of ultrasound-guided regional anesthesia teaching via telesimulation in Ethiopia.MethodsEighteen Ethiopian orthopedic and emergency medicine house staff participated in telesimulation teaching of ultrasound-guided femoral nerve block. This consisted of four 90-min sessions, once per week. Week 1 consisted of a precourse test and a presentation on aspects of performing a femoral nerve block, weeks 2 and 3 were live teaching sessions on scanning and needling techniques, and in week 4, the house staff undertook a postcourse test. All participants were assessed using a validated Global Rating Scale and Checklist.ResultsParticipants were provided with a validated checklist and global rating scale as a pretest and post-test. The participants showed significant improvement in their test scores, from a total mean of 51% in the pretest to 84% in their post-test.ConclusionsTeaching ultrasound-guided regional anesthesia of the femoral nerve remotely via telesimulation is feasible. Telesimulation can greatly improve the accessibility of ultrasound-guided regional anesthesia teaching to physicians in remote areas.
Efficacy and Safety of Modified Yunu-Jian in Patients with Periodontitis: A Meta-Analysis
Authors: Yue Yuanyuan , Gao Meng , Deng Yanru , Shao Jiemin , Sun Yingguang 
Published: April 2021

Background. Modified Yunu-Jian (mYJ), a Chinese medicine (CM) formula, is thought to clear heat and nourish yin. Clinically, it is often used to treat oral inflammation. However, its efficacy remains controversial. Methods. The study aims to evaluate the efficacy and safety of mYJ for treating patients with periodontitis. We searched electronic databases (PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang database, VIP database, and CBM) from inception to December 2020. Only randomized controlled trials investigating modified Yunu-Jian, with or without other medications, against controlled intervention in the treatment of patients diagnosed with periodontitis were included. Both Review Manager 5.3 and Stata 15.0 software were used to analyze the data. The Cochrane Collaborations risk of bias tool was used to assess the quality of the methods. Results. Thirteen clinical trials, involving 1179 participants, were included in our investigation. The results showed that the combination of mYJ with western medicine improved the total effective rate compared with western medicine alone (RR = 1.17, 95% CI (1.12, 1.23),

P

< 0.00001). The sensitivity analysis and Harbord’s test (

P

= 0.255) both showed that the results were statistically robust. Moreover, the periodontal indexes (GI, SBI, PLI, and PD;

P

< 0.00001) of patients with periodontitis were also significantly improved after receiving the combined therapy. No serious adverse reactions were observed in the experimental groups. Conclusions. Evidence from the meta-analysis suggested that mYJ appeared to be effective and relatively safe for treating periodontitis. Because of the low quality of the methods used in the included RCTs, further studies with larger sample sizes and well-designed models are required to confirm our findings.
Autocorrelation and Linear Complexity of Binary Generalized Cyclotomic Sequences with Period pq
Authors: Wang Yan , Yan Liantao , Tian Qing , Ding Liping 
Published: April 2021

Ding constructed a new cyclotomic class

V

0

,

V

1

. Based on it, a construction of generalized cyclotomic binary sequences with period

p
q

is described, and their autocorrelation value, linear complexity, and minimal polynomial are confirmed. The autocorrelation function

C

S

w

is 3-level if

p
≡
3
mod
4

, and

C

S

w

is 5-level if

p
≡
1
mod
4

. The linear complexity

LC

S

>

p
q

/
2

if

p
≡
1

mod

8

,

p
>
q
+
1

, or

p
≡
3
mod
4

or

p
≡
−
3
mod
8

. The results show that these sequences have quite good cryptographic properties in the aspect of autocorrelation and linear complexity.
Comparative Utility of Acupuncture and Western Medication in the Management of Perimenopausal Insomnia: A Systematic Review and Meta-Analysis
Authors: Zhao Fei-Yi , Fu Qiang-Qiang , Kennedy Gerard A. , Conduit Russell , Wu Wen-Zhong , Zhang Wen-Jing , Zheng Zhen 
Published: April 2021

Background. Many women with perimenopausal insomnia (PMI) have sought alternative therapies such as acupuncture because of concerns about risks associated with hormone replacement therapy (HRT) and/or psychotropic drugs. This systematic review aimed to clarify if acupuncture alone or combined with standard Western pharmacotherapy (HRT and/or psychotropic drugs) is more effective in ameliorating PMI in comparison to pharmacotherapy alone. Methods. Randomized controlled trials (RCTs) of PMI treatment via acupuncture alone or combined with Western pharmacotherapy versus Western pharmacotherapy were searched for from eleven databases from inception to March 2020. Cochrane criteria were followed. Results. Fifteen studies involving 1410 women were analyzed. Meta-analysis indicated that acupuncture significantly reduced the global scores of Pittsburgh Sleep Quality Index (PSQI) [MD = −2.38, 95% CI (−3.38, −1.37),

p

< 0.01] and Kupperman Index [MD = −5.95, 95% CI (−10.68, −1.21),

p

= 0.01], compared with hypnotics. Acupuncture combined with hypnotics was more effective than hypnotics alone in decreasing PSQI scores [MD = −3.13, 95% CI (−5.43, −0.83),

p

< 0.01]. Too few RCTs were available to investigate the clinical efficacy differences between acupuncture and HRT/psychotropic drugs other than hypnotics. Conclusions. Despite limited evidence, in comparison to hypnotics, acupuncture was associated with significant improvements in PMI, and reductions of other menopausal symptoms. This finding suggests that acupuncture may be a useful addition to treatment for PMI.
CX3CR1 at V249M and T280M Gene Polymorphism and Its Potential Risk for End-Stage Renal Diseases in Egyptian Patients
Authors: Ibrahim Asmaa Fathelbab , Osman Asmaa Osama Bakr Seddik , Elabbasy Lamiaa M. , Abdelsalam Mostafa , Wahab A. M. , Zaki Maysaa El Sayed , Abdel-Latif Radwa Ahmed Rabea 
Published: April 2021

CX3CL1-CX3CR1 pathway may be one of the future treatment targets to delay the progression of end-stage renal diseases. This study aimed to evaluate the CX3CR gene polymorphism in Egyptian patients with ESRD and its relation to fractalkine blood level. The study included 100 patients with ESRD on dialysis, 61 males and 39 females with mean age 51.02 ± 7.8 years. The V2491 genotype revealed a significant increase in the frequency of GG genotype in healthy control (83%) compared to patients [69%] with a significant increase in GA in patients [30%] compared to control subjects [15%],

P

= 0.03. T280M study showed a statistically significant prevalence of TT genotype in healthy control subjects [86%-OR 95% CI 1.7] compared to patients [70%] with a significant increase in the prevalence of TA in patients [29%] compared to control subjects [13%],

P

= 0.01. There was a significant increase in fractalkine levels in genotypes GA + AA [503.04±224.1] pg/ml compared to genotype GG [423.6 210.3],

P

= 0.03. Moreover, there was a significant increase in the blood level of fractalkine in genotype TA + AA [498.8 219.6] compared to genotype TT [426.8±212.8],

P

= 0.05. In conclusion, our study showed that both V2491-GA genotype and T280M-TA are associated with potential risk for end-stage renal disease in Egyptian patients.
Panorama de la gestión de la innovación en grandes empresas de Chile 2010-2019
Authors: Diaz Molina Iván , Acevedo Rubilar Juan 
Published: April 2021

El objetivo de este artículo es entregar un panorama sobre cómo ha evolucionado la capacidad de gestión de la innovación al interior de grandes empresas en Chile, describiendo sus comportamientos en la última década. Los resultados indican que estas empresas al principio de la década mostraban algún interés por la innovación y tenían iniciativas esporádicas y no sistemáticas -Nivel 1 de maduración-, mientras que en el periodo 2015- 2019 las empresas en general se concentran en la creación de valor y lograr un impacto en sus EBITDA, preparando a la empresa para el futuro -Niveles 3 y 4 de maduración-. La falta de sistematización en los procedimientos de innovación y un rezago en el desarrollo de una cultura de la innovación son elementos que requieren una mejora sustancial en estas organizaciones.
Spatiotemporal movement pattern of Asian Elephants Elephas maximus Linnaeus, 1758 in Sindhudurg District, Maharashtra, India
Authors: Patil Milind Digambar , Patil Vinayak Krishna , Mungi Ninad Avinash 
Published: April 2021

The extension of the Asian Elephant’s Elephas maximus range in the northern Western Ghats (Sahyadri) was observed since 2002. This colonization was marked by elephant crop raiding events in the newly colonized Sindhudurg District, where the local community had no experience of living with elephants. The present study was conducted to understand the spatiotemporal patterns of crop depredation (raiding) and to prioritize areas to inform future interventions on managing this ecological phenomenon turned conflict. Data on crop raiding between 2002 and 2015 was obtained from compensation records with the state forest department, and mapped at village scale. Subsequently, we used three indices of crop raiding, viz., Crop Raiding Frequency (CRF), Relative Crop Raiding Intensity (RCRI), and Crop Raiding Vulnerability Index (CRVI). Results show a gradual northern movement of elephants and of the crop raiding zone over the period of 2002–2015. The rankings provided by CRVI, identified villages in a narrow strip of foothills of the Sahyadri mountains as severely vulnerable. With sufficient long term data, CRVI would be a highly useful index for prioritization of villages for resolving human-elephant negative interactions; and other cases of human-wildlife interactions too.
The Malay Cardamom Meistera aculeata (Roxb.) Škorničk. & M.F. Newman (Zingiberaceae: Alpinioideae) from the Palghat gap: a new record to Kerala, India
Authors: Aswani Vadakkeveedu Jagadesh , Jabeena Manjakulam Khadhersha , Nair Maya Chandrashekaran 
Published: April 2021

Meistera aculeata (Roxb.) Škorničk. & M.F.Newman (Zingiberaceae, subfamily - Alpinioideae) a lesser known species, has been located from the Palakkad (Palghat) Gap region in the Walayar Hill ranges of the southern Western Ghats and reported here as an addition to the flora of Kerala. A detailed taxonomic description along with photographs are provided.