bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validität des „Strukturierten Fragebogens Simulierter Symptome“ [SIMS] bei gesunden Probanden und Patienten mit psychiatrischen Erkrankungen außerhalb eines forensischen Kontexts
Authors: Praus Peter , Schwarz Stefan , Reinhard Iris , Zink Mathias , Dreßing Harald 
Published: June 2021

Zusammenfassung
Ziel der Studie Untersuchung der Rate falsch-positiver SIMS-Resultate bei gesunden Kontrollprobanden und Patienten außerhalb eines forensischen oder rehabilitativen Kontexts.
Methodik Neben dem SIMS wurden Variablen über Fremdratings (PANSS, Hamilton-Skala, MMSE) erfasst. Zielpunkte waren die SIMS- Scores bei Gesunden und einzelnen Patientengruppen und die Zusammenhänge zwischen dem SIMS-Score und weiteren Variablen.
Ergebnisse Patienten mit einer Schizophrenie (n=30) oder einer Depression (n=32) erzielten im Vergleich mit gesunden Probanden (n=36) häufiger SIMS-Scores >16. Patienten mit einer amnestischen Störung (n=15) schnitten im Vergleich hierzu unauffällig ab. Bei depressiven Patienten mit einem auffälligen SIMS-Resultat zeigte sich sowohl ein signifikanter Zusammenhang mit dem Vorliegen einer weiteren psychiatrischen Diagnose als auch eine Korrelation zwischen den Summenwerten auf der Hamilton-Skala und den Werten auf 2 Subskalen des SIMS (NI, AF).
Schlussfolgerung Weitere Validierungsstudien des SIMS sind erforderlich, sollte dieses Instrument auch künftig in der klinischen Praxis angewendet werden. Die Spezifität des SIMS weist wahrscheinlich eine Abhängigkeit vom Untersuchungskontext auf.
Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms
Authors: Qian Jianchang , Li Yinghui , Zhang Xiaodan , Chen Daoxing , Han Mingming , Xu Tao , Chen Bingbing , Hu Guoxin , Li Junwei 
Published: June 2021

AbstractHerbacetin is a bioactive flavanol compound that has various pharmacological effects. However, the pharmacokinetic characteristics have not been thoroughly investigated. Previously, we screened a natural compound library and identified herbacetin as a potent CYP blocker. Herein, we aimed to mechanistically determine the inhibitory effects of herbacetin on CYP450 and its potential application. A human liver microsome incubation system was developed based on a UPLC-MS/MS method. Moreover, an in silico docking assay and a human CYP recombinase reaction system were developed and used to investigate binding affinity and inhibitory efficacy. Subsequently, the effects of the combination of herbacetin and sorafenib on HepG2 cells were assessed by MTT and immunoblotting assays. The concentration of sorafenib and its main metabolite were measured by UPLC-MS/MS after incubation with or without herbacetin. As a result, we found herbacetin almost completely inhibited the functions of major CYPs at 100 µM. Moreover, through analysis of the structure-activity relationship, we found 4-, 6-, and 8-hydroxyl were essential groups for the inhibitory effects. Herbacetin inhibited CYP3A4, CYP2B6, CYP2C9, and CYP2E1 in a mixed manner, but non-competitively blocked CYP2D6. These results are in good agreement with the recombinase reaction in vitro results, with an IC50 < 10 µM for each tested isoenzyme. Interestingly, the stimulatory effects of sorafenib on HepG2 cell apoptosis were significantly enhanced by combining with herbacetin, which was associated with increased sorafenib exposure. In summary, herbacetin is a potent inhibitor of a wide spectrum of CYP450s, which may enhance the exposure of drugs in vivo.
Internal resistive heating of non-metallic samples to 3000 K and &gt;60 GPa in the diamond anvil cell
Authors: Heinen Benedict J. , Drewitt James W. E. , Walter Michael J. , Clapham Charles , Qin Fei , Kleppe Annette K. , Lord Oliver T. 
Published: June 2021

High pressure–temperature experiments provide information on the phase diagrams and physical characteristics of matter at extreme conditions and offer a synthesis pathway for novel materials with useful properties. Experiments recreating the conditions of planetary interiors provide important constraints on the physical properties of constituent phases and are key to developing models of planetary processes and interpreting geophysical observations. The laser-heated diamond anvil cell (DAC) is currently the only technique capable of routinely accessing the Earth’s lower-mantle geotherm for experiments on non-metallic samples, but large temperature uncertainties and poor temperature stability limit the accuracy of measured data and prohibits analyses requiring long acquisition times. We have developed a novel internal resistive heating (IRH) technique for the DAC and demonstrate stable heating of non-metallic samples up to 3000 K and 64 GPa, as confirmed by in situ synchrotron x-ray diffraction and simultaneous spectroradiometric temperature measurement. The temperature generated in our IRH-DAC can be precisely controlled and is extremely stable, with less than 20 K variation over several hours without any user intervention, resulting in temperature uncertainties an order of magnitude smaller than those in typical laser-heating experiments. Our IRH-DAC design, with its simple geometry, provides a new and highly accessible tool for investigating materials at extreme conditions. It is well suited for the rapid collection of high-resolution P–V–T data, precise demarcation of phase boundaries, and experiments requiring long acquisition times at high temperature. Our IRH technique is ideally placed to exploit the move toward coherent nano-focused x-ray beams at next-generation synchrotron sources.
Quantum polyamorphism in compressed distinguishable helium-4
Authors: Kinugawa Kenichi , Takemoto Ayumi 
Published: June 2021

We demonstrate that two amorphous solid states can exist in 4He consisting of distinguishable Boltzmann atoms under compressed conditions. The isothermal compression of normal or supercritical fluid 4He was conducted at 3–25 K using the isobaric–isothermal path integral centroid molecular dynamics simulation. The compression of fluid first produced the low-dispersion amorphous (LDA) state possessing modest extension of atomic necklaces. Further isothermal compression up to the order of 10 kbar to 1 Mbar or an isobaric cooling of LDA induced the transition to the high-dispersion amorphous (HDA) state. The HDA was characterized by long quantum wavelengths of atoms extended over several Angstroms and the promotion of atomic residual diffusion. They were related to the quantum tunneling of atoms bestriding the potential saddle points in this glass. The change in pressure or temperature induced the LDA–HDA transition reversibly with hysteresis, while it resembled the coil–globule transition of classical polymers. The HDA had lower kinetic and higher Gibbs free energies than the LDA at close temperature. The HDA was absent at T ≥ 13 K, while the LDA–HDA transition pressure significantly decreased with lowering temperature. The LDA and HDA correspond to the trapped and tunneling regimes proposed by Markland et al. [J. Chem. Phys. 136, 074511 (2012)], respectively. The same reentrant behavior as they found was observed for the expansion factor of the quantum wavelength as well as for atomic diffusivity.
Ultra-coarse-graining modeling of liquid water
Authors: Li Min , Lu WenCai , Zhang John ZengHui 
Published: June 2021

It is a great challenge to develop ultra-coarse-grained models in simulations of biological macromolecules. In this study, the original coarse-graining strategy proposed in our previous work [M. Li and J. Z. H. Zhang, Phys. Chem. Chem. Phys. 23, 8926 (2021)] is first extended to the ultra-coarse-graining (UCG) modeling of liquid water, with the NC increasing from 4–10 to 20–500. The UCG force field is parameterized by the top-down strategy and subsequently refined on important properties of liquid water by the trial-and-error scheme. The optimal cutoffs for non-bonded interactions in the NC = 20/100/500 UCG simulations are, respectively, determined on energy convergence. The results show that the average density at 300 K can be accurately reproduced from the well-refined UCG models while it is largely different in describing compressibility, self-diffusion coefficient, etc. The density–temperature relationships predicted by these UCG models are in good agreement with the experiment result. Besides, two polarizable states of the UCG molecules are observed after simulated systems are equilibrated. The ion–water RDFs from the ion-involved NC = 100 UCG simulation are nearly in accord with the scaled AA ones. Furthermore, the concentration of ions can influence the ratio of two polarizable states in the NC = 100 simulation. Finally, it is illustrated that the proposed UCG models can accelerate liquid water simulation by 114–135 times, compared with the TIP3P force field. The proposed UCG force field is simple, generic, and transferable, potentially providing valuable information for UCG simulations of large biomolecules.
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
Authors: Vander Roest Alison Schroer , Liu Chao , Morck Makenna M. , Kooiker Kristina Bezold , Jung Gwanghyun , Song Dan , Dawood Aminah , Jhingran Arnav , Pardon Gaspard , Ranjbarvaziri Sara , Fajardo Giovanni , Zhao Mingming , Campbell Kenneth S. , Pruitt Beth L. , Spudich James A. , Ruppel Kathleen M. , Bernstein Daniel 
Published: June 2021

Significance
Heart disease is the leading cause of death worldwide, and hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, affecting over 1 in 200 people. Mutations in myosin, the motor protein responsible for contraction of the heart, are a common cause of HCM but have diverse effects on the biomechanics of the myosin protein. We demonstrate that complex biomechanical effects of mutations associated with heart disease can be effectively studied and understood using a multiscale experimental and computational modeling approach. This work confirms an important role for disruption of the super relaxed state for one particular HCM mutation and provides an approach that can be extended to aid in the understanding of disease mechanisms for different mutations.
Unifying deterministic and stochastic ecological dynamics via a landscape-flux approach
Authors: Xu Li , Patterson Denis , Staver Ann Carla , Levin Simon Asher , Wang Jin 
Published: June 2021

SignificanceCharacterizing stability and dynamics of ecological systems under fluctuations is a longstanding challenge in ecology. We study the ecodynamics of a forest–savanna model under fluctuations via a landscape-flux theoretical framework from nonequilibrium statistical physics and show that ecological dynamics are determined by both population landscape gradients and steady-state probability fluxes. Savanna and forest states coexist under certain conditions, and a grassland state unseen in deterministic cases emerges under fluctuations. The intrinsic landscape is identified with a Lyapunov function for quantifying global stability of ecological systems. We quantify barrier heights, kinetic paths, and switching rates between stable states. Average flux, entropy production rate, time irreversibility, variances in time traces, and fluctuations serve as markers to quantify onset/offset of bifurcations.
Presidential leadership styles and institutional capacity for climate policy integration in the European Commission
Authors: Rietig Katharina , Dupont Claire 
Published: June 2021

ABSTRACT
Climate policy integration (CPI) is a key strategy for implementing climate policy action, spanning policy sectors and levels of governance. As a central agenda-setting actor in the EU, we argue that understanding the institutional capacity for CPI inside the European Commission is especially important for understanding the advancement of CPI in the EU overall. We focus on the inner workings of the Commission, and we ask:what role does the leadership style of the Commission President play in advancing institutional capacity for implementing CPI? We assess the institutional capacity for CPI in the Commission during the Barroso and Juncker Presidencies, which display characteristics of bottom-up and top-down leadership styles, respectively. While we do not find that one presidential leadership style is necessarily ‘better’ than the other at enhancing institutional capacities for CPI, we highlight important differences along four key factors, namely: (1) political commitment to overarching climate objectives and to the necessity of implementing CPI; (2) recognition of functional overlaps between policy objectives and compatible beliefs for implementing CPI among policymakers; (3) an opportunity structure for innovative policy development and policy entrepreneurship; (4) and meaningful coordination and consultation mechanisms.
Full configuration interaction simulations of exchange-coupled donors in silicon using multi-valley effective mass theory
Authors: Joecker Benjamin , Baczewski Andrew D , Gamble John K , Pla Jarryd J , Saraiva André , Morello Andrea 
Published: June 2021

Abstract
Donor spins in silicon have achieved record values of coherence times and single-qubit gate fidelities. The next stage of development involves demonstrating high-fidelity two-qubit logic gates, where the most natural coupling is the exchange interaction. To aid the efficient design of scalable donor-based quantum processors, we model the two-electron wave function using a full configuration interaction method within a multi-valley effective mass theory. We exploit the high computational efficiency of our code to investigate the exchange interaction, valley population, and electron densities for two phosphorus donors in a wide range of lattice positions, orientations, and as a function of applied electric fields. The outcomes are visualized with interactive images where donor positions can be swept while watching the valley and orbital components evolve accordingly. Our results provide a physically intuitive and quantitatively accurate understanding of the placement and tuning criteria necessary to achieve high-fidelity two-qubit gates with donors in silicon.
The analysis of marketing channels and price disparity of shallots in North Sumatera Province
Authors: Purba J A , Supriana T , Maryunianta Y 
Published: June 2021

Abstract
One of the horticultural commodities that is widely cultivated in the province of North Sumatera is shallots. There are 4 districts in North Sumatera which are the centres of shallot production: Samosir, Simalungun, North Tapanuli and Karo. The Objectives of the study is to analyse the marketing channels, price spread, share margin and function of the shallot marketing channel in North Sumatera. The result of this research is that the highest level of disparity in North Sumatera is Channel II in the Karo region with a price difference of IDR. 10,500; selling price at the farmer level IDR. 8,000; selling price at consumer level IDR. 18,500. Meanwhile, the lowest level of disparity is found in Channel I in the Samosir region, with a selling price at the farmer level of IDR. 16,000; and the selling price at the consumer level is IDR. 20,000. The highest level of disparity between marketing institutions in North Sumatera is in channel II in Samosir Regency, which is between the margin ratio of traders and farmers. The lowest level of disparity between marketing institutions in North Sumatera is in channel II in North Tapanuli Regency, which is between the margin ratio of collectors and retailers.
Analysis of organic rice farming income in Kulisusu North Buton District, Southeast Sulawesi
Authors: Tamburaka I P 
Published: June 2021

Abstract
This study aims to determine and analyse the organic rice farming income level the benefit cost ratio between and inhibiting factors in the production process in Kulisusu Village North Buton district. Data were collected through purposive sampling with a total of 40 respondents of organic rice farmers. The results show that organic rice farming income is IDR 28,122,184 or average of IDR 703,054.6 per ha/ harvest season. The return cost ratio (R / C ratio) of 3.65 indicates that R / C > 1, so it is said that organic rice farming is profitable or feasible to be developed or cultivated. Inhibiting factors for organic rice farming, namely capital, seeds, vegetable pesticides, it is expected that the inhibiting factors can be minimized so that farmers can get higher income.
Technical efficiency analysis of rice farmers in Ngawi District, East Java Province
Authors: Saeri M , Lativah E , Antarlina S S , Arifin Z 
Published: June 2021

Abstract
The use of inputs in rice farming which is still based on the experience of farmers influences the level of technical efficiency of farmers. This study aims to analyse the technical efficiency of rice farming in Ngawi District, East Java Province. The method used to analyse technical efficiency is Data envelopment Analysis (DEA) VRS models and tobit regression analysis to determine the factors that influence the technical efficiency of farmers. The respondents used in this study were 88 rice farmers. The results of the study show that there are 60 (68%) farmers who are technically efficient and there are 28 (32%) farmers who are technically inefficient. tobit regression results indicate that there are 6 variables that have a significant effect on technical efficiency including; age, education level, experience, number of families, spacing and quality of seeds. This implies that there is a need for equal distribution of information related to the use of rice production inputs.
Farm analysis and development strategy of strawberry farming (case: Dolat Rayat District, Karo Regency)
Authors: Pinem N F , Nasution S K H , Gunawan R 
Published: June 2021

Abstract
This study aims to determine the farming management system, to analyse the income, feasibility, and development strategy of strawberry farming in Dolat Rayat District, Karo Regency. The analysis method used is the descriptive method, income analysis, feasibility analysis, and SWOT analysis. The results showed that the strawberry farming management system in the study area was not as recommended. The income of the strawberry farmer is IDR. 74,255,470 / Hectare /Year. Analysis results R/C Ratio is 2.296 > 1 so the strawberry farming is feasible to continue. Development strategies that can be applied to strawberry farming are increasing the availability of land and agro-climate, utilizing available labour and production inputs to increase production so that demand for strawberries increases and the market for strawberries widens then conducts training from the government and looks for support institutions for strawberry farming to increase experience and mastery of technology that can increase production results.
Analysis of the feasibility of a polyculture pond business (tilapia – tiger shrimp – crab) (case: Belawan Sicanang Village, Medan Belawan, Medan City)
Authors: Khairini R , Supriana T , Sebayang T 
Published: June 2021

Abstract
This study aims to determine the management system of the polyculture pond business, to analyse the revenue and income of the polyculture pond business, and to analyse the feasibility of a polyculture pond business. The methods of analysis used are descriptive, income analysis, and feasibility analysis. The results showed that the management system of the Polyculture Pond Business was carried out using a semi-intensive system with mixed methods in same pond, the production costs incurred by per hectare were IDR 20,110,213/6 months, all expenses are used together, with revenue of IDR 34,944,000/6 months, the income received is IDR 14,833,787/6 months and the value of R/C is 1.73.
Paddy-fish integrated agricultural system to increase income and food security
Authors: Hasbi  , Tunggal T 
Published: June 2021

Abstract
Paddy-Fish integrated system has been applied by Indonesian farmers. They practiced diversification farming in correlation to get more benefit and minimized risk. The objective of this research was to analyse technical and economical feasibility of paddy-fish integrated system at lowland rice field. This research used the experimental field method. Fish pond was created surrounded the rice field with 3 m in width and 0,5 m in depth where the fish was grown for 4 months. Fishes were fed till they stopped eating. Economical analysis was calculated by comparing between paddy-fish farming system and paddy farmer only. The results of project analysis showed that farmer that grew paddy got a NPV value of IDR 14,925,987 and B/C value of 1.63 so that both were suitable to cultivated. At the same area of 840 m2 the income was IDR 4,773,000 while income of paddy cultivation was IDR. 675,000. There was an extra income of IDR 4,098,000 (33.94 %) when farmer applied paddy-fish cultivation and also minimized a risk if a part of the component failed.
Marketing efficiency of curly red chilli in Karo District
Authors: Kaban M C , Iskandarini  , Supriana T 
Published: June 2021

Abstract
The problem with chilli commodity is the high price fluctuation and unequal price difference at the producer farmer level and the price at the consumer level. This is because the trade chain passed from producers to consumers is quite long, involving many actors, and becoming a cost burden in the marketing process which will ultimately reduce the profit of the marketing chain. This study aimed to see the current description of the curly red chilli marketing channel and to analyse the efficiency of each marketing channel based on marketing margin and farmer’s share. This study used a descriptive analysis method, in which qualitative data was used to analyse the established marketing channels and quantitative data were used in analysing the operational efficiency of marketing using Microsoft Excel 2007 and data tabulation. The results showed that there were 3 marketing channels of curly red chillies commonly passed by farmers in Karo Regency, namely: 1. Farmers →Brokers → Collectors → Retailers → Final Consumers, 2. Farmers → Collectors → Retailers → Final Consumers, 3. Farmers → Brokers → Collectors → Retailers → Final Consumers. Channel II is more efficient because it is used by 52.81% of farmers.
Corn processed product development strategy in SMES industry in Gorontalo Province (Limboto Lake Flavour Shirmp Corn Stick at SMES Barakati)
Authors: Hasan A M , Halid A , Hasdiana  
Published: June 2021

Abstract
The objectives of this study are to identify external and internal factors for the barakati IKM, and to analyse the development strategy of limboto lake shrimp flavoured corn sticks carried out by IKM which is located in Barakati Village. The research location is located at IKM Barakati, Barakati Village. the research method uses survey methods and the types and sources of data used are primary data and secondary data. The sampling technique used was purposive sampling technique or deliberate approach and data analysis in the study used SWOT analysis. The results of the study were the factors that influence the development strategy of limboto lake prawn-flavoured corn sticks in Barakati IKM, Barakati Village, Batudaa District, Gorontalo Regency, namely labour (HR), capital (financial resources), marketing of limboto lake shrimp flavoured corn sticks, para. customers and the existence of strong competitors in the world of the food business. The strategy of developing limboto lake shrimp flavoured corn sticks in Barakati Village, Batudaa District, Gorontalo Regency, which is in quadrant I which supports the progressive strategy or SO (strenght - opportunity) by using the strengths and opportunities you have to minimize the weaknesses and threats that exist so as to achieve progress.