bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of remdesivir in COVID-19 caused by SARS-CoV-2: a systematic review and meta-analysis
Authors: Singh Surjit , Khera Daisy , Chugh Ankita , Khera Pushpinder Singh , Chugh Vinay Kumar 
Published: June 2021

ObjectivesEvaluation of remdesivir, an RNA polymerase inhibitor, for effectiveness in adults with COVID-19.Data sourcesElectronic search for eligible articles of PubMed, Cochrane Central and clinicaltrials.gov was performed on 20 September 2020.Participants and study eligibility criteriaOnly randomised controlled trials (RCTs) evaluating efficacy of remdesivir in COVID-19 were included for meta-analysis.InterventionsRemdesivir was compared with standard of care.Primary and secondary outcomesPrimary outcome was mortality and secondary outcomes were time to clinical improvement and safety outcomes like serious adverse events, respiratory failure.Study appraisal and synthesis methodsData synthesis was done with Cochrane review manager 5 (RevMan) V.5.3. Cochrane risk of bias V.2.0 tool was used for methodological quality assessment. The GRADE pro GDT was applied for overall quality of evidence.Results52 RCTs were screened and 4 studies were included in analysis, with total of 7324 patients. No mortality benefit was observed with remdesivir versus control group (OR=0.92 (95% CI 0.79 to 1.07), p=0.30, moderate quality evidence). Significantly higher rates of clinical improvement (OR=1.52 (95% CI 1.24 to 1.87), p<0.0001, low quality) and faster time to clinical improvement (HR=1.28 (95% CI 1.12 to 1.46), p=0.0002, very low quality) was observed with remdesivir versus control group. Significant decrease was found in the risk of serious adverse events (RR=0.75 (95% CI 0.62 to 0.90), p=0.0003, low quality); however, no difference was found in the risk of respiratory failure (RR=0.85 (95% CI 0.41 to 1.77), p=0.67, very low quality evidence) with remdesivir.ConclusionsAs per the evidence from current review, remdesivir has shown no mortality benefit (moderate quality evidence) in the treatment of COVID-19. From a cost–benefit perspective, it is our personal opinion that it should not be recommended for use, especially in low and lower middle income countries.Trial registration numberPROSPERO registration number: CRD42020189517.
Meta-analysis with individual data of functional outcomes following Aquablation for lower urinary tract symptoms due to BPH in various prostate anatomies
Authors: Elterman Dean , Gilling Peter , Roehrborn Claus , Barber Neil , Misrai Vincent , Zorn Kevin C , Bhojani Naeem , Te Alexis , Humphreys Mitch , Kaplan Steven , Desai Mihir , Bach Thorsten 
Published: June 2021

ObjectivesTo evaluate functional outcomes following Aquablation in various prostate volume and anatomical subgroups.DesignA meta-analysis with individual patient data undergoing Aquablation therapy from four prospective, global, clinical studies that have been conducted with Aquablation; WATER, WATER II, FRANCAIS WATER and OPEN WATER.SettingAustralia, Canada, Lebanon, Germany, New Zealand, UK and the USA.Participants425 men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with 1-year follow-up.InterventionsAquablation therapy is an ultrasound guided, robotically executed waterjet ablative procedure for the prostate.Main outcome measuresThe analyses focus International Prostate Symptom Score (IPSS), uroflowmetry, postoperative Incontinence Severity Index (ISI) and surgical retreatment.Results425 men with prostates ranging in size from 20 to 150 mL underwent Aquablation therapy. The outcomes from the seven questions in the IPSS questionnaire were grouped by the following; prostates <100 mL, prostates ≥100 mL, prostate anatomy with an obstructive median lobe identifed by imaging, and prostate anatomy without an obstructive median lobe. Regardless of subgroup, all outcomes are consistent and demonstrate a significant improvement from baseline. Specifically, improvements in frequency, urgency and nocturia demonstrated bladder function improvement. Patients entering treatment with severe incontinence, ISI score >4, and regardless of prostate size, showed a reduction in incontinence during patient follow-up. Surgical retreatment due to BPH symptoms occurred in 0.7% (95% CI 0.1%–2.0%).ConclusionsAcross a variety of prostate anatomies, Aquablation therapy showed remarkable functional improvements following the index procedure. Additionally, men with moderate to severe LUTS/BPH and overactive bladder resulting in urge incontinence showed a reduction in incontinence symptoms postprocedure.
Spleen emptying does not correlate with faster oxygen kinetics during a step-transition supine cycling
Authors: Zubac Damir , Obad Ante , Bošnjak Ana , Zec Mirela , Ivančev Vladimir , Valić Zoran 
Published: June 2021

This manuscript quantified spleen volume changes and examined the relationship between those changes and oxygen uptake kinetics during supine cycling. Ten volunteers (age = 22 ± 3), completed 3 step transitions from 20 W to their power output at 90% gas exchange threshold. Ultrasonic measurements of the spleen were performed each minute. The largest spleen volume reduction was 105 mL (p = 0.001). No associations existed between i) spleen volumes at rest; and ii) spleen volume changes (%) and tau pulmonary oxygen uptake (τV̇O2p). Larger resting spleen volume and greater emptying do not correlate with a faster τV̇O2p. Novelty: Greater splenic contractions do not augment τV̇O2p, irrespective of spleen emptying and subsequent erythrocyte release.
Constraints on interacting dark energy models through cosmic chronometers and Gaussian process
Authors: Aljaf Muhsin , Gregoris Daniele , Khurshudyan Martiros 
Published: June 2021

AbstractIn this paper, after reconstructing the redshift evolution of the Hubble function by adopting Gaussian process techniques, we estimate the best-fit parameters for some flat Friedmann cosmological models based on a modified Chaplygin gas interacting with dark matter. In fact, the expansion history of the Universe will be investigated because passively evolving galaxies constitute cosmic chronometers. An estimate for the present-day values of the deceleration parameter, adiabatic speed of sound within the dark energy fluid, effective dark energy, and dark matter equation of state parameters is provided. By this, we mean that the interaction term between the two dark fluids, which breaks the Bianchi symmetries, will be interpreted as an effective contribution to the dark matter pressure similarly to the framework of the “Generalized Dark Matter”. We investigate whether the estimates of the Hubble constant and of the present-day abundance of dark matter are sensitive to the dark matter–dark energy coupling. We will also show that the cosmic chronometers data favor a cold dark matter, and that our findings are in agreement with the Le Châtelier–Braun principle according to which dark energy should decay into dark matter.
Leaks of CP violation in the real two-Higgs-doublet model
Authors: Fontes Duarte , Löschner Maximilian , Romão Jorge C. , Silva João P. 
Published: June 2021

AbstractWe discuss the $$Z_2$$

Z
2

symmetric two-Higgs-doublet model with a real soft-breaking term (real 2HDM). We explain in detail why it is not tenable to assume CP conservation in the scalar sector to keep the dimension two term real, while CP is violated by the dimension four Yukawa couplings. We propose the calculation of the infinite tadpole of the (would-be) pseudoscalar neutral scalar. We construct a simple toy model with the same flaws, where the unrenormalizable infinity is easier to calculate. We then consider the same tadpole in the real 2HDM. We spearhead this effort focusing on diagrams involving solely bare quantities. This involves hundreds of Feynman three-loop diagrams that could feed the CP violation from the quark into the scalar sector, and is only possible with state of the art automatic computation tools. Remarkably, some intermediate results agree when using three independent derivations, including the peculiar cancellation of the leading pole divergence due to a subtle interplay between masses and the Jarlskog invariant, which we calculate analytically. The calculation is not complete however, since the full two-loop renormalization of the real 2HDM is not yet available in the literature. Still, we argue convincingly that there is an irremovable infinity.
Diffusion-induced blowup solutions for the shadow limit model of a singular Gierer–Meinhardt system
Authors: Duong G. K. , Kavallaris N. I. , Zaag H. 
Published: June 2021

In this paper, we provide a thorough investigation of the blowing up behavior induced via diffusion of the solution of the following non-local problem: [Formula: see text] where [Formula: see text] is a bounded domain in [Formula: see text] with smooth boundary [Formula: see text] such problem is derived as the shadow limit of a singular Gierer–Meinhardt system, Kavallaris and Suzuki [On the dynamics of a non-local parabolic equation arising from the Gierer–Meinhardt system, Nonlinearity (2017) 1734–1761; Non-Local Partial Differential Equations for Engineering and Biology: Mathematical Modeling and Analysis, Mathematics for Industry, Vol. 31 (Springer, 2018)]. Under the Turing type condition [Formula: see text] we construct a solution which blows up in finite time and only at an interior point [Formula: see text] of [Formula: see text] i.e. [Formula: see text] where [Formula: see text] More precisely, we also give a description on the final asymptotic profile at the blowup point [Formula: see text] and thus we unveil the form of the Turing patterns occurring in that case due to driven-diffusion instability. The applied technique for the construction of the preceding blowing up solution mainly relies on the approach developed in [F. Merle and H. Zaag, Reconnection of vortex with the boundary and finite time quenching, Nonlinearity 10 (1997) 1497–1550] and [G. K. Duong and H. Zaag, Profile of a touch-down solution to a nonlocal MEMS model, Math. Models Methods Appl. Sci. 29 (2019) 1279–1348].
Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm Extraction
Authors: Hattori Hiromitsu , Atsumi Yuko , Nakajo Yukiko , Aono Nobuya , Koizumi Masae , Toya Mayumi , Igarashi Hideki , Kyono Koichi 
Published: June 2021

Background: To evaluate obstetrical and neonatal outcomes of singletons conceived after advanced assisted reproductive technology (ART) techniques: conventional IVF pregnancies (C-IVF), ejaculated sperm intracytoplasmic sperm injection (ICSI), assisted oocyte activation (AOA), in vitro maturation (IVM), and testicular sperm extraction (TESE). Methods: The subjects were 3,028 singletons who were born after fresh or frozen embryo transfer. The subjects were separated into five groups: C-IVF ([Formula: see text]), ICSI ([Formula: see text]), AOA ([Formula: see text]), IVM ([Formula: see text]), and TESE ([Formula: see text]). We evaluated obstetrical and neonatal outcomes calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses for fresh and frozen embryos and for cleavage and blastocyst transfer. The C-IVF group was used as a background control for the ICSI group. Moreover, the TESE, AOA, and IVM groups were compared to the ICSI group to evaluate the effects of the ICSI procedure itself. Results: The incidence of perinatal complications was significantly lower in the ICSI-fresh group ([Formula: see text], 95% CI: 0.10–0.83, [Formula: see text]). Regarding sex ratio, the IVM was significantly associated with sex ratio imbalance toward female in both fresh and frozen groups ([Formula: see text], 95% CI: 0.10–0.96, [Formula: see text], 95% CI: 0.07–0.98, [Formula: see text]). On the other hand, there were no significant differences in preterm birth rate, low birth weight rate and congenital abnormalities rate between conventional IVF, ICSI, and the other groups. Conclusions: There were no negative effects on obstetrical and neonatal outcomes between conventional IVF and ICSI. Although this was a limited sample size study, advanced ART technologies such as AOA, IVM, and TESE also seem to have a low risk of adverse impact on obstetrical and neonatal outcomes but may have a slight impact on sex ratio.
Detecting Receptivity for mHealth Interventions in the Natural Environment
Authors: Mishra Varun , Künzler Florian , Kramer Jan-Niklas , Fleisch Elgar , Kowatsch Tobias , Kotz David 
Published: June 2021

Just-In-Time Adaptive Intervention (JITAI) is an emerging technique with great potential to support health behavior by providing the right type and amount of support at the right time. A crucial aspect of JITAIs is properly timing the delivery of interventions, to ensure that a user is receptive and ready to process and use the support provided. Some prior works have explored the association of context and some user-specific traits on receptivity, and have built post-study machine-learning models to detect receptivity. For effective intervention delivery, however, a JITAI system needs to make in-the-moment decisions about a user's receptivity. To this end, we conducted a study in which we deployed machine-learning models to detect receptivity in the natural environment, i.e., in free-living conditions.
We leveraged prior work regarding receptivity to JITAIs and deployed a chatbot-based digital coach - Ally - that provided physical-activity interventions and motivated participants to achieve their step goals. We extended the original Ally app to include two types of machine-learning model that used contextual information about a person to predict when a person is receptive: a static model that was built before the study started and remained constant for all participants and an adaptive model that continuously learned the receptivity of individual participants and updated itself as the study progressed. For comparison, we included a control model that sent intervention messages at random times. The app randomly selected a delivery model for each intervention message. We observed that the machine-learning models led up to a 40% improvement in receptivity as compared to the control model. Further, we evaluated the temporal dynamics of the different models and observed that receptivity to messages from the adaptive model increased over the course of the study.
Robust Inertial Motion Tracking through Deep Sensor Fusion across Smart Earbuds and Smartphone
Authors: Gong Jian , Zhang Xinyu , Huang Yuanjun , Ren Ju , Zhang Yaoxue 
Published: June 2021

IMU based inertial tracking plays an indispensable role in many mobility centric tasks, such as robotic control, indoor navigation and virtual reality gaming. Despite its mature application in rigid machine mobility (e.g., robot and aircraft), tracking human users via mobile devices remains a fundamental challenge due to the intractable gait/posture patterns. Recent data-driven models have tackled sensor drifting, one key issue that plagues inertial tracking. However, these systems still assume the devices are held or attached to the user body with a relatively fixed posture. In practice, natural body activities may rotate/translate the device which may be mistaken as whole body movement. Such motion artifacts remain as the dominating factor that fails existing inertial tracing systems in practical uncontrolled settings.
Inspired by the observation that human heads induces far less intensive movement relative to the body during walking, compared to other parts, we propose a novel multi-stage sensor fusion pipeline called DeepIT, which realizes inertial tracking by synthesizing the IMU measurements from a smartphone and an associated earbud. DeepIT introduces a data-driven reliability aware attention model, which assesses the reliability of each IMU and opportunistically synthesizes their data to mitigate the impacts of motion noise. Furthermore, DeepIT uses a reliability aware magnetometer compensation scheme to combat the angular drifting problem caused by unrestricted motion artifacts. We validate DeepIT on the first large-scale inertial navigation dataset involving both smartphone and earbud IMUs. The evaluation results show that DeepIT achieves multiple folds of accuracy improvement on the challenging uncontrolled natural walking scenarios, compared with state-of-the-art closed-form and data-driven models.
EVALUATION OF CLOUDS, RADIATION, AND PRECIPITATION IN CMIP6 MODELS USING GLOBAL WEATHER STATES DERIVED FROM ISCCP-H CLOUD PROPERTY DATA
Authors: Tselioudis George , Rossow William. B. , Jakob Christian , Remillard Jasmine , Tropf Derek , Zhang Yuanchong 
Published: June 2021

AbstractA clustering methodology is applied to cloud optical depth cloud top pressure (TAU-PC) histograms from the new, 1-degree resolution, ISCCP-H dataset, to derive an updated global Weather State (WS) dataset. Then, PC-TAU histograms from current-climate CMIP6 model simulations are assigned to the ISCCP-H WSs along with their concurrent radiation and precipitation properties, to evaluate model cloud, radiation, and precipitation properties in the context of the Weather States. The new ISCCP-H analysis produces WSs that are very similar to those previously found in the lower resolution ISCCP-D dataset. The main difference lies in the splitting of the ISCCP-D thin stratocumulus WS between the ISCCP-H shallow cumulus and stratocumulus WSs, which results in the reduction by one of the total WS number. The evaluation of the CMIP6 models against the ISCCP-H Weather States, shows that, in the ensemble mean, the models are producing an adequate representation of the frequency and geographical distribution of the WSs, with measurable improvements compared to the WSs derived for the CMIP5 ensemble. However, the frequency of shallow cumulus clouds continues to be underestimated, and, in some WSs the good agreement of the ensemble mean with observations comes from averaging models that significantly overpredict and underpredict the ISCCP-H WS frequency. In addition, significant biases exist in the internal cloud properties of the model WSs, such as the model underestimation of cloud fraction in middle-top clouds and secondarily in midlatitude storm and stratocumulus clouds, that result in an underestimation of cloud SW cooling in those regimes.
The influence of fire aerosols on surface climate and gross primary production in the Energy Exascale Earth System Model (E3SM)
Authors: Xu Li , Zhu Qing , Riley William J. , Chen Yang , Wang Hailong , Ma Po-Lun , Randerson James T. 
Published: June 2021

AbstractFire-emitted aerosols play an important role in influencing Earth’s climate, directly by scattering and absorbing radiation and indirectly by influencing cloud microphysics. The quantification of fire-aerosol interactions, however, remains challenging and subject to uncertainties in emissions, plume parameterizations, and aerosol properties. Here we optimized fire-associated aerosol emissions in the Energy Exascale Earth System Model (E3SM) using the Global Fire Emissions Database (GFED) and AERONET aerosol optical depth (AOD) observations during 1997-2016. We distributed fire emissions vertically using smoke plume heights from Multi-angle Imaging SpectroRadiometer (MISR) satellite observations. From the optimization, we estimate that global fires emit 45.5 Tg y-1 of primary particulate organic matter and 3.9 Tg y-1 of black carbon. We then performed two climate simulations with and without the optimized fire emissions. We find that fire aerosols significantly increase global AOD by 14 ± 7% and contribute to a reduction in net shortwave radiation at the surface (-2.3 ± 0.5 W m-2). Together, fire-induced direct and indirect aerosol effects cause annual mean global land surface air temperature to decrease by 0.17 ± 0.15°C, relative humidity to increase by 0.4 ± 0.3%, and diffuse light fraction to increase by 0.5 ± 0.3%. In response, GPP declines by 2.8 Pg C y-1, as a result of large positive drivers (decreases in temperature and increases in humidity and diffuse light) nearly cancelling out large negative drivers (decreases shortwave radiation and soil moisture). Our analysis highlights the importance of fire aerosols in modifying surface climate and photosynthesis across the tropics.
Evaluation of an Enhanced Recovery After Surgery Protocol Including Parasternal Intercostal Nerve Block in Cardiac Surgery Requiring Sternotomy
Authors: Abadi Arad , Cohen Robbin 
Published: June 2021

Background Recent guidelines for perioperative care in cardiac surgery recommend multimodal pain management to decrease opioid use. We evaluated the effect of multimodal pain management including parasternal intercostal nerve block on pain control and opioid use in patients who underwent coronary artery bypass grafting (CABG) requiring sternotomy and cardiopulmonary bypass. Study Design Medical records of consecutive patients who underwent CABG from 2018 to 2019 at Huntington Hospital were retrospectively queried. Patients were divided in 2 groups based on whether an Enhanced Recovery After Surgery (ERAS) pain management protocol including parasternal intercostal nerve blocks was employed. Outcomes, including length of stay, pain scores, and opioid use, were compared. Results There was no difference in length of stay (days) 5.43 vs. 5.38 ( P = .45 and average pain score 2.23 vs. 3.27 ( P = .137) for patients in the ERAS and non-ERAS groups. Maximum pain score, 7.74 to 6.15 ( P = .015), and opioid use (total morphine mg equivalent), 149.64 to 32.01 ( P < .01), were reduced in the ERAS group. Conclusion The ERAS multimodal pain management protocol utilizing intraoperative parasternal blocks appears to reduce pain and decrease opioid use after CABG.
Fruit and vegetable intake at and away from school during participation in the FIT Game
Authors: Ansu Velarie , Madden Gregory , Wengreen Heidi 
Published: June 2021

Background: The FIT Game is a multicomponent school-based incentive program aimed at increasing children’s fruit and vegetable (FV) intake. There has been no previous report on how playing the game at school influences FV intake away from school. Aim: To examine children’s ( n=37) FV intake away from school while participating in the FIT Game program at school. Methods: FV intake away from school was assessed using the ASA24-Kids-2014 Dietary Assessment Tool. Paired samples t-tests and the generalized linear model repeated measures analysis of variance were used to examine the difference in children’s mean FV intake away from school. Results: During the final three days of the FIT Game intervention, we observed no change in FV consumption away from school (p=0.30). Similarly, no differences were observed between FV intake away from school before the implementation of the FIT Game and during the final three days (p=0.81). Conclusions: The FIT Game modestly decreased the children’s FV intake in a nonstatistically significant manner away from school. Our previous report showed an increase in children’s FV intake at school; thus, the net effect of the game was a significant increase in total daily FV intake.