bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Novel HSD17B4 Heterozygous Mutations in Association With D-Bifunctional Protein Deficiency: A Case Report and Literature Review
Authors: Chen Si , Du Linrun , Lei Yihui , Lin Yuanyuan , Chen Shangqin , Liu Yanli 
Published: July 2021

Background: D-Bifunctional protein deficiency (D-BPD) is an autosomal recessive disorder caused by peroxisomal β-oxidation defects. According to the different activities of 2-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase protein units, D-bifunctional protein defects can be divided into four types. The typical symptoms include hypotonia and seizures. The gene that encodes D-BP was HSD17B4, which is located in chromosome 5q23.1.Case Presentation: We report the first case of D-BPD in a Chinese patient with neonatal onset. Cosmetic malformations, severe hypotonia and seizures are prominent. The blood bile acid profile showed increased taurocholic acid, glycocholic acid, and taurochenodeoxycholic acid. Very-long-chain fatty acids (VLCFAs) revealed significant increases in hexacosanoic acid (C26:0), tetracosanoic acid/docosanoic acid (C24:0/C22:0), and hexacosanoic acid/docosanoic acid (C26:0/C22:0). Cranial MRI revealed bilateral hemispheric and callosal dysplasia, with schizencephaly in the right hemisphere. EEG showed loss of sleep–wake cycle and epileptiform discharge. Other examinations include abnormal brainstem auditory evoked potentials (BAEPs) and temporal pigmented spots on the optic disc in the right eye. After analysis by whole-exome sequencing, heterozygous c.972+1G&gt;T in the paternal allele and c.727T&gt;A (p.W243R) in the maternal allele were discovered. He was treated with respiratory support, formula nasogastric feeding, and antiepileptic therapy during hospitalization and died at home due to food refusal and respiratory failure at the age of 5 months.Conclusions: Whole-exome sequencing should be performed in time to confirm the diagnosis when the newborn presents hypotonia, seizures, and associated cosmetic malformations. There is still a lack of effective radical treatment. Supportive care is the main treatment, aiming at controlling symptoms of central nervous system like seizures and improving nutrition and growth. The disease has a poor outcome, and infants often die of respiratory failure within 2 years of age. In addition, heterozygous deletion variant c.972+1G&gt;T and missense mutations c.727T&gt;A (p.W243R) are newly discovered pathogenic variants that deserve further study.
The Role of Coping Behavior in Healthcare Workers' Distress and Somatization During the COVID-19 Pandemic
Authors: Franck Erik , Haegdorens Filip , Goossens Eva , van Gils Yannic , Portzky Michael , Somville Francis , Abuawad Majed , Slootmans Stijn , Van Bogaert Peter 
Published: July 2021

Background: Constantly searching for a balance between work demands and their own physical and psychological health has challenged medical and nursing staff during the immediate wake of this COVID-19 viral epidemic leading to acute stress reactions and psychosomatic symptoms. Coping behavior might be a buffer for work-related stress in relation to mental well-being. The present study aims to evaluate the role of positive and negative stress-reducing activities on healthcare workers' mental and physical well-being.Methods: This was a cross-sectional study using an online survey that was sent out using our network of healthcare workers at the University of Antwerp and through social media. Socio-demographic data, coping behavior with the Palliative Pallet Scale (P3), and distress and somatization using the Four-dimensional symptom checklist were collected. Surveys were completed by 1,376 participants.Results: The results clearly showed that positive stress-reducing activities are related to fewer symptoms of distress and somatization. Providing direct care to COVID-19 patients was associated with a higher decrease of applying positive stress-reducing activities during the peak of the pandemic compared to the ideal situation. Finally, fewer symptoms of distress and somatization were associated with the following activities: reading, mind sports games, keeping a hobby collection, studying; engaging in sexual activities with your partner; cleaning the house, tidying up, working in the garden, doing household chores; exercising alone; walking, or taking a trip together with someone; exercise together with someone; watching TV, listening/playing (to) music/, playing computer games; playing a card game or other board game; and preparing something extra tasteful outside regular meals.Conclusion: Our study demonstrated an association between concrete coping behaviors and distress and somatization in healthcare workers during the first peak of the COVID-19 pandemic. The results provide relevant and additional insights to develop and investigate interventions among others in personal leadership and resilience.
Virtual Reality-Assisted Cognitive Behavioral Therapy for Anxiety Disorders: A Systematic Review and Meta-Analysis
Authors: Wu Jinlong , Sun Yi , Zhang Gongwei , Zhou Zhenhui , Ren Zhanbing 
Published: July 2021

Objective: We aim to explore the effectiveness of virtual reality-assisted cognitive behavioral therapy (VRCBT) in the treatment of anxiety and depression in patients with anxiety disorders. We further compare the therapeutic effect of VRCBT with that of standard cognitive behavioral therapy (CBT), as well as investigate the long-term efficacy of VRCBT.Methods: As of March 3, 2020, a total of four databases (Web of Science, PubMed, PsycINFO, and Scopus) were retrieved, and two researchers independently conducted literature retrieval and research selection and performed data extraction. Methodological quality assessment was performed using the Cochrane risk of bias tool and Grading of Recommendation, Assessment, Development, and Evaluation tool (GRADE).Results: A total of 11 studies were included (n = 626; range, 25.3–43.8), and six randomized controlled trials were quantitatively analyzed. The main outcome was anxiety and depression, and the secondary outcome was the withdrawal rate and long-term effects. Meta-analysis showed that the therapeutic effect of VRCBT on anxiety was better than that of the waiting list group (WLG) (SMD = −0.92; 95% CI: −1.34, −0.50; p = 0.005, I2 = 66%, n = 276), while the therapeutic effect of VRCBT on anxiety was similar to that of standard CBT treatment (SMD = −0.26; 95% CI: −0.50, −0.01; p = 0.77, I2 = 0%, n = 150). We further found that the therapeutic effect of VRCBT on depression was better than that of the WLG (SMD = −1.29; 95% CI: −2.26, −0.32; p = 0.09, I2 = 58%, n = 74), while the effect of VRCBT was similar to that of standard CBT (SMD = −0.30; 95% CI: −0.67, −0.07; p = 0.39, I2 = 1%, n = 116). Of the five studies that reported withdrawal rates of patients during the VRCBT and CBT treatment process, the withdrawal rates of the VRCBT group and CBT group did not reach statistical significance (OR = 0.70, 1.48, p &gt; 0.05); only two studies reported the long-term effectiveness of VRCBT in anxiety and depression on patients with anxiety disorders.Conclusion: VRCBT treatment has a specific positive effect on patients with anxiety disorders (anxiety and depression). Compared with standard CBT, similar therapeutic effects can be achieved in the treatment of anxiety disorders. However, limited randomized controlled trials were included, requiring that these results be treated with caution.
Effects of Chronic Alcohol Use Disorder on the Visual Tilt Illusion
Authors: Gao Guoqing , Yin Liangshuang , Cheng Jun , Tao Rui , Liu Yu , Pang Liangjun , Wang Zhengchun 
Published: July 2021

Rationale: Among the serious consequences of alcohol use disorder (AUD) is the reduced ability to process visual information. It is also generally agreed that AUD tends to occur with disturbed excitation–inhibition (EI) balance in the central nervous system. Thus, a specific visual behavioral probe could directly qualify the EI dysfunction in patients with AUD. The tilt illusion (TI) is a paradigmatic example of contextual influences on perception of central target. The phenomenon shows a characteristic dependence on the angle between the inducing surround stimulus and the central target test. For small angles, there is a repulsion effect; for larger angles, there is a smaller attraction effect. The center-surround inhibition in tilt repulsion is considered to come from spatial orientational interactions between orientation-tuned neurons in the primary visual cortex (V1), and tilt attraction is from higher-level effects of orientation processing in the visual information processing.Objectives: The present study focuses on visual spatial information processing and explores whether chronic AUD patients in abstinence period exhibited abnormal TI compared with healthy controls.Methods: The participants are 30 male volunteers (20–46 years old) divided into two groups: the study group consists of 15 clinically diagnosed AUD patients undergoing abstinence from alcohol, and the control group consists of 15 healthy volunteers. The TI consists of a center target surround with an annulus (both target and annulus are sinusoidal grating with spatial frequency = 2 cycles per degree). The visual angle between center and surround is a variable restricted to 0°, ±15°, ±30°, or ±75°. For measuring the TI, participants have to report whether the center target grating orientation tilted clockwise or counterclockwise from the internal vertical orientation by pressing corresponding keys on the computer keyboard. No feedback is provided regarding response correctness.Results: The results reveal significantly weaker tilt repulsion effect under surround orientation ±15° (p &lt; 0.05) and higher lapse rate (attention limitation index) under all tested surround orientations (all ps &lt; 0.05) in patients with chronic AUD compared with health controls.Conclusions: These results provide psychophysical evidence that visual perception of center-contextual stimuli is different between AUD and healthy control groups.
The Influence of Mental Health Literacy, Migration, and Education on the Duration of Untreated Psychosis
Authors: Takizawa Naomi , Melle Ingrid , Barrett Elizabeth Ann , Nerhus Mari , Ottesen Akiah A. 
Published: July 2021

Background: Duration of untreated psychosis (DUP) is associated with outcome in psychotic disorders and influenced by contextual factors such as immigration. Here we aimed to investigate the effect of mental health literacy (MHL) on duration of untreated psychosis considering the influence of migration and education.Methods: A total of 269 participants who received their first adequate medical treatment for a psychotic disorder within the current or past year were included to the Thematically Organized Psychosis study in Oslo, Norway. Sociodemographic and clinical information was collected through systematic interviews. MHL was measured as “recognition of psychotic symptoms” and assessed by “The Attitudes and Beliefs about Mental Health Problems” schizophrenia version. Influence of education, migration and MHL on DUP was analyzed with hierarchical block-wise multiple regression analysis.Results: Recognition of psychotic symptoms explained a small but unique variance (2.3%) in DUP after the effects of other important predictors were controlled for. Longer DUP was also associated with less education, lower premorbid social, and academic functioning, a diagnosis within schizophrenia spectrum disorder, and earlier age of onset. The model explained 26% of variance in DUP. Migration after the age of six and length of education were associated with MHL but did not have a significant interaction with MHL in predicting DUP.Conclusions: MHL, measured as recognition of psychotic symptoms, has a small but significant independent effect on DUP. The effect of MHL was larger than years of education and migration history, and did not interact with either, in predicting DUP. This suggests that MHL is an independent factor in prevention strategies for early psychosis.
The Multi-hub Academic Conference: Global, Inclusive, Culturally Diverse, Creative, Sustainable
Authors: Parncutt Richard , Lindborg PerMagnus , Meyer-Kahlen Nils , Timmers Renee 
Published: July 2021

New conference formats are emerging in response to COVID-19 and climate change. Virtual conferences are sustainable and inclusive regardless of participant mobility (financial means, caring commitments, disability), but lack face-to-face contact. Hybrid conferences (physical meetings with additional virtual presentations) tend to discriminate against non-fliers and encourage unsustainable flying. Multi-hub conferences mix real and virtual interactions during talks and social breaks and are distributed across nominally equal hubs. We propose a global multi-hub solution in which all hubs interact daily in real time with all other hubs in parallel sessions by internet videoconferencing. Conference sessions are confined to three equally-spaced 4-h UTC timeslots. Local programs comprise morning and afternoon/evening sessions (recordings from night sessions can be watched later). Three reference hubs are located exactly 8 h apart; additional hubs are within 2 h and their programs are aligned with the closest reference hub. The conference experience at each hub depends on the number of local participants and the time difference to the nearest reference. Participants are motivated to travel to the nearest hub. Mobility-based discrimination is minimized. Lower costs facilitate diversity, equity, and inclusion. Academic quality, creativity, enjoyment, and low-carbon sustainability are simultaneously promoted.
Recent Developments in Rodent Models of High-Fructose Diet-Induced Metabolic Syndrome: A Systematic Review
Authors: Chan Alvin Man Lung , Ng Angela Min Hwei , Mohd Yunus Mohd Heikal , Idrus Ruszymah Bt Hj , Law Jia Xian , Yazid Muhammad Dain , Chin Kok-Yong , Shamsuddin Sharen Aini , Lokanathan Yogeswaran 
Published: July 2021

Metabolic syndrome (MetS) is the physiological clustering of hypertension, hyperglycemia, hyperinsulinemia, dyslipidemia, and insulin resistance. The MetS-related chronic illnesses encompass obesity, the cardiovascular system, renal operation, hepatic function, oncology, and mortality. To perform pre-clinical research, it is imperative that these symptoms be successfully induced and optimized in lower taxonomy. Therefore, novel and future applications for a disease model, if proven valid, can be extrapolated to humans. MetS model establishment is evaluated based on the significance of selected test parameters, paradigm shifts from new discoveries, and the accessibility of the latest technology or advanced methodologies. Ultimately, the outcome of animal studies should be advantageous for human clinical trials and solidify their position in advanced medicine for clinicians to treat and adapt to serious or specific medical situations. Rodents (Rattus norvegicus and Mus musculus) have been ideal models for mammalian studies since the 18th century and have been mapped extensively. This review compiles and compares studies published in the past five years between the multitude of rodent comparative models. The response factors, niche parameters, and replicability of diet protocols are also compiled and analyzed to offer insight into MetS-related disease-specific modelling.
MÉTODO NÃO DESTRUTIVO PARA DETERMINAÇÃO DA ÁREA FOLIAR DE Turnera subulata
Authors: Queiroz Castro Aline , Dos Santos Conceição Gabriel , Singulani de Brito Gabriela , Barbosa dos Santos Quezia , Tognere Jasmyn , De Souza Oliveira Vinicius , Dousseau Arantes Sara , Schmildt Omar , Romais Schmildt Edilson 
Published: July 2021

Turnera subulata é uma planta medicinal que tem demostrado associação com o processo de cicatrização. A determinação da área foliar é importante parâmetro em estudos agronômicos, fisiológicos e morfológicos das diversas espécies vegetais. Essa determinação pode ser feita de forma destrutiva ou não destrutiva. Dentre os métodos não destrutivos se destaca a uso de equações matemáticas que relacionam a área foliar e as medidas lineares das folhas como o comprimento, largura e sua combinação. Desta forma, objetivou-se com este estudo ajustar e validar uma equação matemática que estima a área foliar de T. subulata de forma não destrutiva. Assim, com base em 350 folhas, foram ajustadas equações de modelo lineares de primeiro grau, quadrático e potência, em que a área foliar observada foi utilizada como variável dependente em função das medidas lineares do comprimento, largura e produto da multiplicação do comprimento com a largura. Todas as equações ajustadas foram validadas através de critérios apropriados a partir de uma amostra de 100 folhas separadas unicamente para esta finalidade. Desse modo, a equação de modelo quadrático obtida a partir do produto da multiplicação do comprimento com a largura é a mais adequada para estimar a área foliar de T. subulata de maneira simples e precisa.
TECNOLOGIA DE PREPARO DE SEMENTES DE ABÓBORA
Authors: Souza dos Santos Letícia , Meireles Celestino Robson , Silva dos Reis Luciléa , Arndt Stella 
Published: July 2021

Objetivou-se com o presente experimento avaliar a eficiência do método de água em alta pressão utilizando uma bomba doméstica para retirada da mucilagem de sementes de abóbora. O experimento foi submetido aos seguintes tratamentos: T0) Fermentação por 72 horas seguidas por lavagem em peneira de arame; e submissão das sementes ao jato de água com pressão por T1) 0 Segundo (testemunha com a mucilagem); T2) 10 Segundos; T3) 20 Segundos; T4) 30 Segundos; T5) 40 Segundos: T6) 50 Segundos. As sementes foram avaliadas de acordo com as seguintes variáveis de germinação e de vigor: Teste de germinação, primeira contagem de germinação, massa da matéria fresca/seca da plântula, comprimento de raiz e de parte aérea. O delineamento utilizado foi o inteiramente casualizado (DIC) com quatro repetições, sendo cada uma constituída por 50 sementes. O método de jato de água em alta pressão para a retirada da mucilagem de sementes de abóbora apresenta maior eficiência que os demais, pois mantêm a mesma qualidade, sendo ainda um processo mais rápido. Os tempos de submissão ao jato d’água que proporcionam os melhores desempenhos de germinação e de vigor variam de 10 a 50 segundos. Dessa forma, conclui-se que a retirada da mucilagem de sementes de abóbora pode ser efetuada por meio de jatos d`água em alta pressão, sendo eficiente a partir de 10 segundos de submissão.
Strategic framework of professional preparation of trainees in the field of security and defense, professional field of Administration and Management - Socio-demographic and educational aspects
Authors: Petrova Elitsa 
Published: July 2021

ObjectivesTo clarify the factors that influence the individual’s career orientation and professional fulfillment of cadets, which can be deeply personal as well as dictated and conditioned by the external environment.MethodsA Survey of trainee opinion in the professional field of Administration and Management at the National Military University.ResultsThe study focuses on the socio-demographic and educational aspects of the need for training in the professional field of Administration and Management, following the example of the Department of Security Logistics, National Military University, Bulgaria. Respondents in the survey were 164 trainees from 5 consecutive years of study in the Bachelor's degree program in the professional field of “Military Affairs”.ConclusionsIt is necessary to direct its efforts to recruit future trainees mainly from secondary schools, vocational high schools of economics and vocational high schools of mechanical and electrical engineering, trainees from families with low- and middle-income, trainees with strong personal motivation to practice the military profession, trainees who achieve high results in their education. The information channels for accessing better, timely and reliable information about the applying process and training at the Vasil Levski National Military University should be expanded using social networks, media and more information campaigns in schools. To a large extent, parental opinion about trainees’ choice of the military profession, also has an influence which was found to be very positive.
USULAN PERMINTAAN PRODUK SN 5 ML DI PT. XYZ DENGAN METODE TIME SERIES
Authors: Sambas Sundana  , Al Gufronny Destri Zahra 
Published: July 2021

Permasalahan yang dihadapi PT. XYZ yaitu kesulitan dalam menentukan jumlah permintaan produk yang harus tersedia untuk periode berikutnya agar tetap dapat memenuhi kebutuhan pelanggan dan tidak menyebabkan penumpukan barang dalam jangka waktu yang lama terutama produk SN 5 ML yang memiliki permintaan jumlah paling besar dari produk lainnya. Tujuan dari penelitian ini yaitu menentukan metode peramalan yang tepat untuk meramalkan jumlah permintaan produk SN 5 ml periode Januari sampai dengan Desember 2021 Metode yang digunakan dalam penelitian ini yaitu metode peramalan Moving Average (MA), Weighted Moving Average (WMA), Single Exponential Smoothing (SES), dan Double Exponential Smoothing (DES). Adapun langkah langkah peramalan yang dilakukan yaitu menentukan tujuan peramalan,memilih unsur apa yang akan diramal, menentukan horizon waktu peramalan (pendek, menengah, atau panjang), memilih tipe model peramalan, mengumpulkan data yang di perlukan untuk melakukan peramalan, memvalidasi dan menerapkan hasil peramalan Berdasarkan perhitungan didapat metode peramalan dengan persentase tingkat kesalahan terkecil dibandingkan dengan metode lainnya yaitu metode Moving Average (MA) dengan hasil yang diperoleh permintaan produk SN 5 ML pada bulan Januari sampai dengan Desember 2021 yaitu sebanyak 22.844.583 unit
ANALISA PERSEDIAAN STOCK BARANG DENGAN MENGGUNAKAN METODE ECONOMIC OERDER QUANTITY DI UD TOKO PLASTIK HANIF
Authors: Andan Saiful Amar  , Kristanto Mulyono  , Nurjanah Susianti 
Published: July 2021

Pada umumnya setiap perusahaan memiliki berbagai jenis persediaan baik itu perusahaan perdagangan, manufaktur dan jasa selalu menyediakan persediaan. UD Toko Plastik Hanif adalah sebuah perusahaan dagang (distributor) yang melakukan transaksi pembelian dan penjualan secara grosir untuk agen-agen kecil. Permasalahan lainnya yang terjadi dalam pengelolaan data barang masih menggunakan cara manual dengan mencatat ke dalam buku. Salah satu metode yang tepat dalam meminimalisir permasalahan pada menggunakan metode EOQ (Economic Order Quantity), tujuan dari metode ini untuk meminimalisir out of stock pada proses penjualan dan pembelian. Setelah dilakukannya penerapan EOQ ditemukan tingginya biaya persediaan yang dihasilkan, dan dari analisa persediaan dengan menggunakan metode EOQ berhasil melakukan penghematan dibandingkan sebelum menggunakan metode EOQ