bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and molecular characterization of a large cohort of childhood onset hereditary spastic paraplegias
Authors: Giordani Gabriela Marchisio , Diniz Fabrício , Fussiger Helena , Gonzalez-Salazar Carelis , Donis Karina Carvalho , Freua Fernando , Ortega Roberta Paiva Magalhães , de Freitas Julian Letícia , Barsottini Orlando Graziani Povoas , Rosemberg Sergio , Kok Fernando , Pedroso José Luiz , França Marcondes Cavalcante , Saute Jonas Alex Morales 
Published: November 2021

AbstractThe present study aimed to characterize clinical and molecular data of a large cohort of subjects with childhood-onset hereditary spastic paraplegias (HSPs). A multicenter historical cohort was performed at five centers in Brazil, in which probands and affected relatives' data from consecutive families with childhood-onset HSP (onset < 12 years-old) were reviewed from 2011 to 2020. One hundred and six individuals (83 families) with suspicion of childhood-onset HSP were evaluated, being 68 (50 families) with solved genetic diagnosis, 6 (5 families) with candidate variants in HSP-related genes and 32 (28 families) with unsolved genetic diagnosis. The most common childhood-onset subtype was SPG4, 11/50 (22%) families with solved genetic diagnosis; followed by SPG3A, 8/50 (16%). Missense pathogenic variants in SPAST were found in 54.5% of probands, favoring the association of this type of variant to childhood-onset SPG4. Survival curves to major handicap and cross-sectional Spastic Paraplegia Rating Scale progressions confirmed the slow neurological deterioration in SPG4 and SPG3A. Most common complicating features and twenty variants not previously described in HSP-related genes were reported. These results are fundamental to understand the molecular and clinical epidemiology of childhood-onset HSP, which might help on differential diagnosis, patient care and guiding future collaborative trials for these rare diseases.
Survey on security issues of routing and anomaly detection for space information networks
Authors: Zhuo Ming , Liu Leyuan , Zhou Shijie , Tian Zhiwen 
Published: November 2021

AbstractSpace information networks is network systems that can receive, transmit, and process spatial information lively. It uses satellites, stratosphere airships, Unmanned Aerial Vehicles, and other platforms as the carrier. It supports high-dynamic, real-time broadband transmission of earth observations and ultra-long-distance, long-delay reliable transmission of deep space exploration. The deeper the network integration, the higher the system’s security concerns and the more likely SINs will be controlled and destroyed in terms of cybersecurity. How to integrate new IT technologies such as artificial intelligence, digital twins, and blockchain to diverse application scenarios of SINs while maintaining SIN cybersecurity will be a long-term critical technical issue. This study is a review of the security issues for space information networks. First, this paper examines space information networks’ security issues and figures out the relationship between the main security threats, services, and mechanisms. Then, this article selects secure routing and anomaly detection from many security technologies to conduct a detailed overview from two perspectives of traditional methods and artificial intelligence. Subsequently, this paper investigates anomaly detection schemes for spatial information networks and proposes a deep learning-based anomaly detection scheme. Finally, we suggest the potential research directions and opening problems of space information network security. Overall, this paper aims to give readers an overview of the newly emerging technologies in space information networks’ security issues and provide inspiration for future exploration.
RETRACTED ARTICLE: Middle east pain syndrome is a pollution-induced new disease mimicking rheumatoid arthritis
Authors: Elbeialy Adel A. , Bauomi Abdlnby M. , Elnaggar Basma M. , Elzomor Hala M. 
Published: November 2021

AbstractMusculoskeletal pains are sometimes misdiagnosed in some diseases, like rheumatoid and psoriatic arthritis, erosive OA, etc. Secondary hyperparathyroidism was not considered a differential diagnosis for RA, despite the fact that it can cause arthralgia or arthritis. Also, fibromyalgia is a psychosomatic condition marked by widespread pain and tenderness. This study included 400 patients attended certain outpatient clinics of Rheumatology in Egypt and Saudi Arabia, who were not fulfilling criteria for RA diagnosis. Criteria for classification of fibromyalgia syndrome were applied to all patients. We did lab tests and radiological imaging modalities for diagnosis or exclusion of suspected diseases were applied. All patients were fulfilling both old and new criteria of fibromyalgia syndrome, and not fulfilling any RA criteria, and had vitamin D3 deficiency or insufficiency. 75% of patients had abnormally high levels of PTH, without parathyroid gland pathology. Radiology showed subperiosteal and subchondral resorption of mainly thumbs, subchondral osteopenia of proximal and middle phalanges, mild subperiosteal resorption along the radial aspect of the middle phalanx and mild tuft erosions, besides changes in the carpus closely resembling those of rheumatoid arthritis, of ulnar styloid resorption, radiocarpal and scapho-trapezoid joint arthritis. Of special interest, the presence of tuft spur-like excrescences.
Winter distribution of juvenile and sub-adult male Antarctic fur seals (Arctocephalus gazella) along the western Antarctic Peninsula
Authors: March David , Drago Massimiliano , Gazo Manel , Parga Mariluz , Rita Diego , Cardona Luis 
Published: November 2021

AbstractDetailed knowledge of habitat use by marine megafauna is critical to understand their ecological roles and for the adequate management of marine resources. Antarctic fur seals (Arctocephalus gazella) inhabiting the Atlantic sector of the Southern Ocean prey largely on Antarctic krill (Euphausia superba) and play a central role in managing the krill fishery. Here, we assessed the demographic structure of three post-mating, early moult male haul-outs in the South Shetland Islands in early March and calculated the relative contribution of juveniles (1–4 years old) and sub-adult males (5–6 years) to the population remaining in maritime Antarctica after the breeding season. We also satellite tagged 11 juvenile males and four sub-adult males to analyze their movements and develop a species distribution model including both age classes. Our results highlighted the dominance of young individuals in the male population, revealed that they do not behave as central place foragers and identified key environmental drivers that affected their distribution at-sea throughout winter. Predicted potential foraging habitat overlapped highly with the known distribution of Antarctic krill, and identified the waters off the western Antarctic Peninsula and the Scotia Sea as the core of the distribution area of juvenile and sub-adult male Antarctic fur seals in winter. This pattern is similar to that of adult males but totally different from that of adult females, as the latter overwinter in areas at latitude 45–55° S. This segregation has implications for the ecology and management of the krill fishery.
Cerebral and systemic hemodynamic effect of recurring seizures
Authors: Ferlini Lorenzo , Su Fuhong , Creteur Jacques , Taccone Fabio Silvio , Gaspard Nicolas 
Published: November 2021

AbstractThe increase in neuronal activity induced by a single seizure is supported by a rise in the cerebral blood flow and tissue oxygenation, a mechanism called neurovascular coupling (NVC). Whether cerebral and systemic hemodynamics are able to match neuronal activity during recurring seizures is unclear, as data from rodent models are at odds with human studies. In order to clarify this issue, we used an invasive brain and systemic monitoring to study the effects of chemically induced non-convulsive seizures in sheep. Despite an increase in neuronal activity as seizures repeat (Spearman’s ρ coefficient 0.31, P < 0.001), ictal variations of cerebral blood flow remained stable while it progressively increased in the inter-ictal intervals (ρ = 0.06, P = 0.44 and ρ = 0.22; P = 0.008). We also observed a progressive reduction in the inter-ictal brain tissue oxygenation (ρ =  − 0.18; P = 0.04), suggesting that NVC was unable to compensate for the metabolic demand of these closely repeating seizures. At the systemic level, there was a progressive reduction in blood pressure and a progressive rise in cardiac output (ρ =  − 0.22; P = 0.01 and ρ = 0.22; P = 0.01, respectively), suggesting seizure-induced autonomic dysfunction.
Assessing the impact of land surface temperature on urban net primary productivity increment based on geographically weighted regression model
Authors: Lu Xue-Yuan , Chen Xu , Zhao Xue-Li , Lv Dan-Jv , Zhang Yan 
Published: November 2021

AbstractUrbanization had a huge impact on the regional ecosystem net primary productivity (NPP). Although the urban heat island (UHI) caused by urbanization has been found to have a certain promoting effect on urban vegetation NPP, the factors on the impact still are not identified. In this study, the impact of urbanization on NPP was divided into direct impact (NPPdir) and indirect impact (NPPind), taking Kunming city as a case study area. Then, the spatial heterogeneity impact of land surface temperature (LST) on NPPind was analyzed based on the geographically weighted regression (GWR) model. The results indicated that NPP, LST, NPPdir and NPPind in 2001, 2009 and 2018 had significant spatial autocorrelation in Kunming based on spatial analytical model. LST had a positive impact on NPPind in the central area of Kunming. The positively correlation areas of LST on NPPind increased by 4.56%, and the NPPind caused by the UHI effect increased by an average of 4.423 gC m−2 from 2009 to 2018. GWR model can reveal significant spatial heterogeneity in the impacts of LST on NPPind. Overall, our findings indicated that LST has a certain role in promoting urban NPP.
Offene Verletzungen und Frakturen – Notfallbehandlung und definitive Versorgung
Authors: Kamin Konrad , Notov Dmitry , Al-Sadi Onays , Kleber Christian , Bönke Florian , Dragu Adrian , Schaser Klaus-Dieter 
Published: November 2021

ZusammenfassungEine erfolgreiche Behandlung von offenen Verletzungen von Frakturen hängt von vielen Einflussfaktoren ab (Inflammation, Perfusion, Kompartmetsyndrom). Neben lokalen Besonderheiten der verletzten Körperregion spielen patientenbezogene Grunderkrankungen eine wesentliche Rolle (Stoffwechselerkrankungen, Arteriosklerose). Der therapeutische Erfolg wird häufig nur interdisziplinär erzielt.Die initiale Therapie findet idealerweise schon am Unfallort statt. Luxationsfrakturen müssen zwingend reponiert und geschient werden, offene Frakturen im Anschluss steril abgedeckt. Neben der Stabilisierung der Vitalfunktion muss eine vollumfängliche körperliche Untersuchung und Diagnostik mit Gefäßdarstellung und Fotodokumentation im Schockraum stattfinden. Hier wird auch der Tetanusschutz eruiert und eine kalkulierte antimikrobielle Therapie eingeleitet.Offene Frakturen werden dann nach dem Damage Control Prinzip im OP exploriert, debrediert und transfixiert. Manifeste
oder drohende Kompartmentsyndrome müssen gespalten werden, ggf. muss mithilfe der Gefäßchirurgie eine Revaskularisation angestrebt werden. Sollte eine plastisch-chirurgische Expertise vor Ort sein, so ist diese so früh wie möglich einzubinden. Häufig wird das Ausmaß des sekundären Gewebsschadens erst durch weitere Débridements und Gewinnung von Gewebeproben sichtbar. Der geeignete Zeitpunkt für die definitive Osteosynthese hängt vom Gesamtzustand des Patienten ab. Diaphysäre Frakturen werden in der Regel mit einem Verriegelungsmarknagel weichteilschonend operativ versorgt. Gelenk- oder metaphysäre Frakturen werden hingegen durch winkelstabile Plattensysteme stabilisiert. Der vital bedrohte Patient oder Patienten mit einem ausgedehnten Weichteilschaden können von einem Ilizarov-Hybridfixateur profitieren. Limitierend für jede Osteosynthese sind die Weichteilverhältnisse. Sollte die temporäre Weichteildeckung notwendig werden, so wird im eigenen Vorgehen zunächst ein
Epigard gewählt mit second look nach 24 Stunden und Wechsel auf einen Vakuumversiegelungssystem (V. A. C. Therapy). Mittels plastisch-chirurgischer Konsultation lässt sich schon frühzeitig die optimale Deckung der posttraumatischen Defekte planen.
Single-Anastomosis Procedures in Metabolic Surgery
Authors: Qudah Yaqeen , Barajas-Gamboa Juan S. , Sun Helen , Del Gobbo Gabriel Díaz , Kroh Matthew , Corcelles Ricard 
Published: November 2021

AbstractThe most effective long-term treatment for severe obesity is bariatric surgery with improvement or resolution of obesity-related comorbidities. Single-anastomosis procedures including single-anastomosis duodenoileal bypass and one-anastomosis gastric bypass are relatively new procedures that are gaining popularity worldwide. These surgical techniques are perceived to be less complex with a shorter learning curve in comparison to the standard biliopancreatic diversion with duodenal switch and Roux-en-Y gastric bypass; however, long-term outcomes and complications remain controversial. This article aims to review one-anastomosis procedures, evaluate their outcomes, and review potential complications.
Genetic interaction and inheritance of important traits in durum (
Authors: Mohammadi Majid , Mirlohi Aghafakhr , Majidi Mohammad Mahdi , Esmaeilzadeh Moghaddam Mohsen , Rabbani Farzaneh , Noori Fatemeh 
Published: November 2021

Emmer wheat (Triticum turgidum ssp. dicoccum) is an important gene source for wheat improvement but less studied in crosses with its descendant species durum (Triticum turgidum ssp. durum), especially in respect to the type of genetic components, intergenic interactions and the genetic mechanisms governing responses to drought. In this study, generation means analysis was performed using F1, F2, BC1P1 and BC1P2 from two different crosses of emmer × durum. Seeds were planted in a RCBD design with three replications under two water regimes. Results showed that there was a highly considerable difference between generations for all studied traits. The presence of significant mean parameter for all the traits, indicated the quantitative inheritance of the traits. Estimating the number of effective genes, polygenic control of the traits were confirmed. In moisture stress condition, epistatic effect for grain yield and yield-related traits illustrated the importance of epistasis in plant adaptation and performance stability. The additive × additive effect, which is fixable, was remarkable in both crosses. Under both water regimes, narrow-sense heritability was relatively high and estimates of gain from selection were positive for most of the traits. Among generations studied, the backcrosses were superior for drought tolerant indices. Based on the results, emmer wheat seems to have genetic potential for durum improvement.
Factors influencing the jump momentum – sprint momentum correlation: a data simulation
Authors: McErlain‐Naylor Stuart A. , Beato Marco 
Published: November 2021

ABSTRACTJump take‐off momentum has previously been proposed as an alternative test to predict sprint momentum. This study used a data simulation to replicate and systematically investigate relationships reported in previous studies between body mass, vertical jump performance, and sprint performance. Results were averaged for 1000 simulated data sets in each condition, and the effects of various parameters on correlations between jump momentum and sprint momentum were determined. The ability of jump take‐off momentum to predict sprint momentum is greatest under relatively high inter‐individual variation in body mass and relatively low inter‐individual variation in jump height. This is largely due to the increased emphasis on body mass in these situations. Even under zero or a small negative (r = −0.30) correlation between jump height and sprint velocity, the correlation between the two momenta remained very large (r ≥ 0.76) on average. There were no investigated conditions under which jump momentum was most frequently a significantly (p < 0.05) greater predictor of sprint momentum compared to simply using body mass alone. Furthermore, between‐individual correlations should not be used to make inferences or predictions for within‐individual applications (e.g. predicting or evaluating the effects of a longitudinal training intervention). It is recommended that any rationale for calculating and/or monitoring jump take‐off momentum should be separate from its ability to predict sprint momentum. Indeed, body mass alone may be a better predictor of sprint momentum.Highlights
This study replicated and systematically perturbed relationships reported in the literature to investigate factors contributing to correlations between jump momentum and sprint momentum.
The ability of jump take‐off momentum to predict sprint momentum is greatest under relatively high inter‐individual variation in body mass and relatively low inter‐individual variation in jump height. This is largely due to the increased emphasis on body mass in these situations.
Even under zero or a small negative correlation between jump height and sprint velocity, the correlation between the two momenta remained very large on average. There were no investigated conditions under which jump momentum was a better predictor of sprint momentum compared to simply using body mass alone.
It is recommended that any rationale for calculating and/or monitoring jump take‐off momentum should be separate from its ability to predict sprint momentum. Indeed, body mass alone may be a better inter‐individual predictor of sprint momentum if such a prediction were deemed necessary.
Intensity and anisotropies of the stochastic gravitational wave background from merging compact binaries in galaxies
Authors: Capurri Giulia , Lapi Andrea , Baccigalupi Carlo , Boco Lumen , Scelfo Giulio , Ronconi Tommaso 
Published: November 2021

Abstract
We investigate the isotropic and anisotropic components of the Stochastic Gravitational Wave Background (SGWB) originated from unresolved merging compact binaries in galaxies. We base our analysis on an empirical approach to galactic astrophysics that allows to follow the evolution of individual systems. We then characterize the energy density of the SGWB as a tracer of the total matter density, in order to compute the angular power spectrum of anisotropies with the Cosmic Linear Anisotropy Solving System (CLASS) public code in full generality. We obtain predictions for the isotropic energy density and for the angular power spectrum of the SGWB anisotropies, and study the prospect for their observations with advanced Laser Interferometer Gravitational-Wave and Virgo Observatories and with the Einstein Telescope. We identify the contributions coming from different type of sources (binary black holes, binary neutron stars and black hole-neutron star) and from different redshifts. We examine in detail the spectral shape of the energy density for all types of sources, comparing the results for the two detectors. We find that the power spectrum of the SGWB anisotropies behaves like a power law on large angular scales and drops at small scales: we explain this behavior in terms of the redshift distribution of sources that contribute most to the signal, and of the sensitivities of the two detectors. Finally, we simulate a high resolution full sky map of the SGWB starting from the power spectra obtained with CLASS and including Poisson statistics and clustering properties.
Disparities in the body, chest, and wing morphometric among three subspecies of local male chickens for genetic breeding
Authors: Putranto H D , Nurmeiliasari  , Yumiati Y , Nur A M 
Published: November 2021

Abstract
Local chickens in developing countries, including Indonesia, have great potential to be developed into natural superior breeds to support food security and improve farmer welfare. Meanwhile, the major endemic subspecies found in the Bengkulu province are burgo and kampung chicken, as well as ketarras which are recently bred intensively. Therefore, this study aims to analyze the disparities in the morphometrics of three subspecies of local male chickens specifically on the body weight, length, chest girth and length, as well as wing span. Based on the results, the male burgo chicken morphometrical size was significantly smaller than ketarras, while the ketarras chicken was significantly smaller than kampung (P < 0.05). Furthermore, the average body weights for the burgo, ketarras and kampung chicken were 1.0, 1.2 and 1.9 kg cock-1, respectively, while the average of body length, chest and chest length, as well as wing span were 29.9, 40.0, 47.7 cm cock-1; 26.2, 30.1, 36.3 cm cock-1; 12.6, 17.8, 20.3 cm cock-1, and 34.4, 41.9, 55.9 cm cock-1, respectively. Therefore, it was concluded that the burgo and kampung chicken have the smallest and biggest morphometric sizes respectively.
The role of organic fertilizer from natural dye waste and mycorrhizal inoculation on the growth of Indigofera tinctoria L.
Authors: Budiastuti M T S , Supriyono  , Manurung I R , Setyaningrum D , Nurmalasari A I , Arista N I D 
Published: November 2021

Abstract
Management of Indigofera tinctoria as a natural dye produces organic waste that has not been utilized. One of the proper managements of organic waste is to process it into organic fertilizer. This study examines the role of organic fertilizer waste and mycorrhizae on the growth and yield of Indigofera tinctoria. The study used a completely randomized block design with two factors: organic waste fertilizer and mycorrhizae. The results showed that organic fertilizers and mycorrhizae did not affect the net assimilation and leaf area indexes. The combination of organic fertilizers with mycorrhizae supports leaf growth. The combination of 400 g.plant−1 organic fertilizer and 10 g.plant−1 mycorrhizal fertilizer increased the number of leaves by 257%. Organic fertilizer has a significant effect on the fresh weight of the crown, fresh weight and root biomass. Organic fertilizer dose of 200 g.plant−1 increased fresh root weight, root biomass and fresh crown weight by 68.5%, 68.29% and 63.27% respectively. Mycorrhizae 10 g.plant−1 increased root length by 23.54%. Leaf growth correlated with length, fresh weight and root biomass. Organic fertilizer from the extraction of Indigofera tinctoria is an effort to achieve zero waste to support plant growth.
Local wisdom in the preservation and diversification of medicinal plant use (A case study of the Lawu mountainside community on the island of Java, Indonesia)
Authors: Wibowo A , Setyawati A , Masyithoh G , Rahayu E S 
Published: November 2021

AbstractThe Lawu mountainside community uses local wisdom in its preservation of medicinal plants. The goal of this research is to describe the role of local wisdom in preserving and diversifying the use of medicinal plants. The research uses a qualitative method with an explorative approach to explore local wisdom and the optimization of medicinal plants. The research results show that the Lawu mountainside community, who use a wealth of local wisdom in the preservation and optimization of the diversification of medicinal plant use, supported by the potential of natural beauty, have managed to preserve and transfer this local wisdom to the younger generation and create a tourism site to attract visitors. This has had implications on economic and social cultural aspects. In the economic aspect, it has led to a development in the local economy, while in the social cultural aspect, it has brought about an internalization of ecological values in management of the natural environment.