bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of nurse-led transitional care interventions for patients with heart failure on healthcare utilization: A meta-analysis of randomized controlled trials
Authors: Li Minlu , Li Yuan , Meng Qingtong , Li Yinyin , Tian Xiaomeng , Liu Ruixia , Fang Jinbo 
Published: December 2021

Background
Heart failure (HF) imposes a substantial burden on patients and healthcare systems. Hospital-to-home transitional care, involving time-limited interventions delivered predominantly by nurses, was introduced to lighten this burden. This study aimed to examine the effectiveness and dose-response of nurse-led transitional care interventions (TCIs) on healthcare utilization among patients with HF.

Methods
Health-related databases were systematically searched for articles published from January 2000 to June 2020. We included randomized controlled trials (RCTs) that compared nurse-led TCIs with usual care for adults hospitalized with HF and reported the following healthcare utilization outcomes: all-cause readmissions, HF-specific readmissions, emergency department visits, or length of hospital stay. Random-effects meta-analysis, meta-regression analysis, and dose-response analysis were performed to estimate the treatment effects and explain the heterogeneity.

Results
Twenty-five RCTs including 8422 patients with HF were included. Nurse-led TCIs for patients with HF resulted in a mean 9% (RR = 0.91; 95% CI = 0.82 to 0.99; p = 0.04; I2 = 46%) and 29% (RR = 0.71; 95% CI = 0.60 to 0.84; p < 0.0001; I2 = 0%) reduction in all-cause and HF-specific readmission risks respectively compared to usual care. The interventions were also effective in shortening the length of hospital stay (MD = -2.37; 95% CI = -3.16 to -1.58; p < 0.0001; I2 = 14%). However, no significant reduction was found for emergency department visits (RR = 0.96; 95% CI = 0.84 to 1.10; p = 0.58; I2 = 0%). The effect of meta-regression coefficients on all-cause and HF-specific readmissions was not statistically significant for any prespecified trial-level characteristic. Dose-response analysis revealed that the HF-specific readmission risk decreased in a dose-dependent manner with the complexity and intensity of nurse-led TCIs.

Conclusions
Nurse-led TCIs were effective in decreasing all-cause and HF-specific readmission risks, as well as in reducing the length of hospital stay; however, the interventions were not effective in reducing the frequency of emergency department visits.
Usher syndrome: diagnostic approach, differential diagnoses and proposal of an updated function-based genetic classification
Authors: Bolz Hanno J. 
Published: December 2021

Abstract
Usher syndrome (USH) manifests with congenital and apparently isolated hearing loss, followed by retinal degeneration in later life. Therefore, and because of its high prevalence in the congenitally hearing-impaired population, USH is one of the most relevant deafness syndromes. Next-generation sequencing (NGS)-based testing can now provide most analyzed USH patients with a molecular diagnosis, based on mutations in 11 genes. Given the availability of several excellent articles on the clinical and biochemical basis of USH, this short review focuses on critical assessment of new genes announced as USH genes, clinical and genetic differential diagnoses and therapeutic developments. Because obsolete loci, disproved USH genes and the inclusion of genes whose mutations cause similar phenotypes have increasingly blurred genetic classification, a revision based on phenotype restricted to genes related to the Usher protein complex is proposed.
Genetic counseling and the role of genetic counselors in the United States
Authors: Schaaf Christian P. 
Published: December 2021

Abstract
Genetic counselors represent an indispensable, well-established, and well-integrated group of healthcare providers in the field of genetic and genomic medicine in the United States. They work with other members of the healthcare team to provide information and support to individuals and families concerned with genetic disorders. With more than 5,000 certified genetic counselors in the U.S. and an expected growth of 100 % over the next decade, genetic counseling represents one of the fastest-growing professions in the U.S.
Genetic counselors work in clinical environments (e. g., hospitals), in companies (e. g., genetic testing firms), and as consultants to medical practices and others. Twenty-six states license genetic counselors as practitioners who can bill independently, with licensure applications underway in the remaining 24 states.
Physicians, genetic counselors, and diagnosticians represent the three pillars of comprehensive, integrated genomic medical care. Within this triad, genetic counselors see their primary role in procuring and interpreting family and medical histories, assessing inheritance, quantifying chances of recurrence, facilitating decision-making regarding genetic testing options, and explaining the results of such testing to the respective individuals within the greater context of their families.
Organ-on-a-chip technologies to study neuromuscular disorders: possibilities, limitations, and future hopes
Authors: Lauffer Marlen C. 
Published: December 2021

Abstract
Neuromuscular disorders are a heterogeneous group of diseases ranging from mild to devastating phenotypes depending on the disorder’s origin. Pathophysiologies for many of these disorders are not fully understood and efficient therapies are urgently needed. Recent advances in the field of induced pluripotent stem cells and organ-on-a-chip technologies have brought enormous improvement in modeling neuromuscular diseases. Even complex units, like the neuromuscular junction, can now be built, enabling researchers to study each component of the motor unit by itself or interacting with others, allowing the identification of disease mechanisms. This article aims to introduce these new modeling systems to study neuromuscular disorders and the possibilities of organ-on-a-chip platforms to shed light on disease pathologies and their use for therapy development.
Bringing CCM into a dish: cell culture models for cerebral cavernous malformations
Authors: Skowronek Dariush , Pilz Robin A. , Schwefel Konrad , Much Christiane D. , Felbor Ute , Rath Matthias 
Published: December 2021

Abstract
Cerebral cavernous malformations (CCMs) are vascular lesions that can cause severe neurological complications due to intracranial hemorrhage. Although the CCM disease genes, CCM1, CCM2, and CCM3, have been known for more than 15 years now, our understanding of CCM pathogenesis is still incomplete. CCM research currently focuses on three main disease mechanisms: (1) clonal expansion of endothelial cells with biallelic inactivation of CCM1, CCM2, or CCM3, (2) recruitment of cells with preserved CCM protein expression into the growing lesion, and (3) disruption of endothelial cell–cell junctions in CCMs. We here describe novel CRISPR/Cas9-based in vitro models of CCM and discuss their strengths and limitations in the context of high-throughput drug screening and repurposing approaches.
“What I want to do I do not do”: on bi- and multilingual repertoires and linguistic dislocation in a border town
Authors: Ding Seong Lin , Chee Wei Han 
Published: December 2021

AbstractLanguage problems and language barriers are challenges facing not only immigrants but also minorities and people in rural/semirural areas. This study examines individuals’ bi- and multilingual repertoires, language practices and attitudes in a Hokkien-speaking community in Kangar, a semirural town of northern Malaysia bordering Thailand. Through questionnaire surveys and interviews, we investigate how these notions can be used as a means to understand/reflect bilingualism and multilingualism and, more importantly, the potential disparity between what people want to do/say and what people eventually manage to do/say. While there is a shift in language practice from a local- and ancestral origin-induced pattern towards a more “global” and “pan-Chinese” paradigm, the findings also reveal the linguistic “dislocations” of the Hokkien-speaking community across ALL generations regardless of ethnicity. The language issues in the community reflect—and are likely to be reflections of—society at large. The vast contrast between individual/societal linguistic aspirations and the actual linguistic repertoire/communicative competence among the locals indicates the need to redress an absence of major efforts to close urban-rural/city-town/dominant-dominated social divides across the (language) education landscape at the national level.
Translanguaging as a resource for meaning-making at multilingual construction sites
Authors: Kahlin Linda , Keevallik Leelo , Söderlundh Hedda , Weidner Matylda 
Published: December 2021

Abstract
In this article we investigate spoken professional interaction at construction sites in Sweden, where workers from Poland, Ukraine and Estonia are temporarily employed as carpenters, ground workers and kitchen installers. We study how the workers use resources associated with different languages and how these resources are mobilized along with embodied resources for meaning-making. The analysis aims at investigating what social space the workers construct by going between or beyond different linguistic structures, as defined in the theory of translanguaging. The study is based on Linguistic Ethnography and Conversation Analysis is used for close analysis. We focus on instances of translanguaging, such as Swedish-sounding institutionalized keywords, practices of receptive multilingualism and the search for communicative overlaps in repertoires. The findings from busy construction sites show that the stratifying aspect gives some workers a voice in the organization, while others remain silent. Hence, it is primarily professionals functioning as team leaders, who talk to different occupational categories and use resources associated with different languages. The data provide an opportunity to investigate the theory of translanguaging and its transformative power in relation to professional settings that are linguistically diverse, but also strictly hierarchical.
Crisis of Multilateralism and Cities’ Helping Hand
Authors: Szpak Agnieszka 
Published: December 2021

AbstractThis essay shows how cities are stepping into the role of nation-states and are efficiently cooperating with other cities, not only bilaterally but also multilaterally. There are clear symptoms of the crisis of multilateralism that have led cities to attempt to save or fix the multilateral system and solve global problems, notably the current COVID-19 pandemic. Can cities be regarded as a helping hand or as a fix for the multilateral system? With discourse analysis and formal-legal analysis, this article concludes that the answer to the question is positive – cities may help to fix or save the multilateral system.
Bedeutung von Spiritualität in einer ganzheitlichen Psychotherapie
Authors: Ernesti Alina , Neumann Melanie , Weger Ulrich , Edelhäuser Friedrich 
Published: December 2021

Zusammenfassung
Spiritualität als ein fundamentales Bedürfnis des Menschseins stellt auch in der Psychotherapie einen wichtigen Einflussfaktor dar. Ziel dieser Studie ist es, die Bedeutung der spirituellen Dimension in der gegenwärtigen Psychotherapie zu erforschen. Dazu wurden sieben ganzheitlich orientierte Therapeutinnen und Therapeuten zu ihrer Arbeitsweise befragt. Anhand Problemzentrierter Interviews wurde exploriert, inwiefern die spirituelle Perspektive der befragten Personen ihre therapeutische Arbeit beeinflusst. Dabei wurde insbesondere der Frage nachgegangen, wie die spirituelle Dimension konkret in die therapeutische Praxis einbezogen und der Umgang mit der weltanschaulichen Passung zwischen Therapeut/-in und Patient/-in gehandhabt wird. Darüber hinaus wurde die Relevanz einer Integration der spirituellen Perspektive in die Psychotherapie thematisiert. Die Interviews wurden mittels Qualitativer Inhaltsanalyse nach Mayring ausgewertet.
Zentrales Ergebnis der Studie ist, dass sich die spirituelle Orientierung der befragten Personen vor allem in ihrer inneren Haltung und in ihrem Therapieverständnis ausdrückt, welches sich durch ein ganzheitliches und spirituelles Menschenbild auszeichnet. Spirituelle Interventionen spielen dagegen eine untergeordnete Rolle. Eine weltanschauliche Beeinflussung der Patientinnen und Patienten wird entschieden abgelehnt. Stattdessen wird ein sensibler und bedürfnisorientierter Umgang mit spirituellen Themen betont. Existenziellen Fragestellungen kommt dabei eine besondere Bedeutung zu. Die Integration einer spirituellen Dimension in die Psychotherapie unter Wahrung professioneller und ethischer Grenzen wird als sehr bereichernd erachtet.
Synthesis, crystal structure and properties of a 2-D Cd(II) coordination polymer based on ferrocenecarboxylate and 4,4′-bipyridine ligands
Authors: Zhong Kai-Long , Quan Jing , Pan Xian-Xiao , Song Wei , Li Bing-Feng 
Published: December 2021

Abstract
A new cadmium(II)-based coordination polymer [Cd3(FcCOO)6(4,4′-bipy)(H2O)2]
n
(FcCOO = ferrocenecarboxylato and 4,4′-bipy = 4,4′-bipyridine) has been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction. The results of a crystal structural analysis has revealed that the title compound consists of two crystallographically unique CdII centers, one in a general position with a five-coordinated and one on an inversion center with a six-coordinated environment. The CdII centers are connected by FcCOO− units to form a metal carboxylate oxygen chain extending parallel to the [100] direction while the 4,4′-bipy ligands further act as bridging linkers of the CdII centers resulting in a layered polymer. In addition, an X-ray powder diffraction and thermal gravimetric analysis and a cyclo-voltammetric characterization of the complex have also been carried out.
Africa and The Decline of The Democracy Debate
Authors: Salih Mohamed 
Published: December 2021

The debate on the decline of democracy is not new. It can be traced to the period between the First and Second World Wars, and it resurfaced during the 1970s, followed by the most spectacular dem- ocratic resurgence in human history. This lecture focuses on the current debate on the decline of democracy and downward trends in major democracy assessment indices. Africa is among the three least democratic world regions, with 42% of African countries cur- rently designated as not free.
Measuring the decline or rise of democracy only by the perfor- mance of institutional politics does not provide a complete picture of the issue. Institutional politics does not account for the resil- ience and thriving new spaces where democratic vibrancy and civic engagement prevail. Examples from African countries demonstrate that democracy indices based on institutional politics alone do not account for alternative democratic spaces and practices. This paper is the edited version of the keynote speech delivered by the author at the 6th Pécs African Studies Conference under the theme “African Realities: Conflict and Cooperation”, September 23-24, 2021 – University of Pécs, Hungary.
Colgajo perforante de la arteria circunfleja ilíaca superficial para la cobertura de defectos en los miembros
Authors: Valbuena Sebastián Emiliano , Pereira Emanuel Fernando , Conde Braian Nicolás 
Published: December 2021

El colgajo perforante de la arteria circunfleja ilíaca superficial se utiliza para la reconstrucción de los miembros, sobre todo, en el dorso de las manos y los pies, en la zona de flexión articular y en cirugía maxilofacial, porque es un colgajo fino, flexible y versátil. Presentamos tres pacientes: dos casos pediátricos para la reconstrucción de secuelas traumáticas de la mano y el dorso del pie, y un adulto para la reconstrucción de una quemadura del dorso de la mano.
Conclusiones: El colgajo perforante de la arteria circunfleja ilíaca superficial es ideal para el dorso de la mano, el pie y los pliegues articulares. Pese a las variaciones anatómicas en el nacimiento de la arteria circunfleja ilíaca superficial, el dominio de las técnicas microquirúrgicas y de la supermicrocirugía permite tomar, con seguridad, un colgajo de dimensiones moderadas o grandes, fino, con baja morbilidad en la zona dadora.
El Puntaje predictivo de resultado en la cirugía reconstructiva de miembros inferiores. Ensayo preliminar
Authors: Vivas Mauro Rafael 
Published: December 2021

Introducción: Las secuelas postraumáticas en los miembros son un cuadro de muy difícil abordaje por la gravedad de las lesiones, la falta de protocolos de tratamiento y especialmente por la elección de la mejor alternativa. El objetivo de este estudio fue analizar el resultado del tratamiento reconstructivo con un puntaje prequirúrgico diseñado para tal fin y evaluar su predictibilidad de resultado.
Materiales y Métodos: Se realizó un análisis retrospectivo de tipo cohorte de los resultados del tratamiento con fijación externa en 32 pacientes con secuela traumática de la pierna en los últimos siete años que fueron estadificados con un puntaje preoperatorio elaborado para tal fin y comparado con el resultado obtenido con la tabla de resultados de la ASAMI con dos años de seguimiento mínimo.
Resultados: Se obtuvo una relación directa entre la estadificación prequirúrgica y el resultado final. Dicha relación se ve reflejada en el alto porcentaje de excelentes resultados en pacientes de bajo riesgo (50%) y una tasa del 60% de malos resultados en pacientes de alto riesgo.
Conclusiones: La evidencia actual es contradictoria y se discute cuál es la mejor opción de tratamiento. Los pacientes considerados de alto riesgo tienen un alto porcentaje de malos resultados y tal vez no se beneficien con la cirugía reconstructiva.
Artroplastia total de rodilla posterior a osteotomía tibial alta. Estudio retrospectivo comparativo entre osteotomías sustractivas y aditivas
Authors: Tillet Fernando , Rodríguez Joaquín Aníbal , Del Sel Hernán , Lopreite Fernando Adrián 
Published: December 2021

Introducción: El reemplazo total de rodilla luego de una osteotomía tibial alta plantea dificultades técnicas adicionales. El objetivo de este estudio fue analizar los resultados clínicos y radiográficos de la conversión a reemplazo total de rodilla luego de una osteotomía tibial alta y comparar la evolución de los pacientes con una osteotomía de cierre (sustractiva) o de apertura (aditiva) previa.Materiales y Métodos: Se analizó retrospectivamente una serie de 46 artroplastias de rodilla realizadas entre 1997 y 2019, en 39 pacientes con antecedente de osteotomía tibial alta. Se evaluaron los parámetros clínicos y radiográficos antes de la artroplastia y después, determinando el eje femorotibial, la caída tibial posterior, el valor de Insall-Salvati y el Knee Society Score. También se compararon los resultados en pacientes con antecedente de osteotomía tibial sustractiva vs. aditiva.
Resultados: El seguimiento promedio fue de 5.72 años (mín. 1, máx. 19). El Knee Society Score de la serie tuvo una mejoría promedio de 42,3 a 79,8. La caída tibial posterior y el índice de Insall-Salvati no sufrieron grandes modificaciones luego de la cirugía. La supervivencia promedio de la osteotomía aditiva hasta la conversión a reemplazo total de rodilla fue de 5.5 años, mientras que la de la sustractiva, de 13.5 años.
Conclusiones: Pese a la dificultad técnica que puede plantear, el reemplazo total de rodilla luego de una osteotomía tibial alta valguizante tuvo una buena evolución clínico-radiográfica a corto y mediano plazo, y el tipo de osteotomía no repercutió en los resultados luego de la artroplastia
O entrelaçar da história e da ficção em Só as mulheres sangram
Authors: Henriques Elizane Souza dos Santos , Rodrigues Inara de Oliveira 
Published: December 2021

Neste estudo, problematizamos as relações entre a história e a ficção em quatro, dos nove, contos que compõem a narrativa afro-brasileira Só as mulheres sangram, escrita por Lia Vieira (2017). A obra aponta à vulnerabilidade social da população negra no Brasil, e às heranças escravagista, colonial e patriarcal. Para desvendar tais questões a pesquisa, bibliográfica e analítica, tem como base teórica as relações entre a História e a Literatura (PESAVENTO, 2003; RICOUER, 1997; GINZBURG, 2007); a concepção de literatura afro-brasileira (DUARTE; 2016); e a Teoria do conto (GOTLIB, 2012; MARIA, 2004). A análise permitiu concluir que os contos mantêm diálogo constante com a realidade histórica na qual se inserem. Ao dar ênfase à afetividade e a ancestralidade do povo negro, bem como à emancipação feminina, tais narrativas valorizam a identidade e o lócus enunciativo desses sujeitos, fomentando, assim, reflexões sobre a necessidade de enfrentamento das desigualdades e dos fluxos hegemônicos.
Tolerancia in vitro de cultivares de Rubus spp. a estrés hídrico simulado con manitol
Authors: Millones Carlos , Vásquez Ernestina 
Published: December 2021

Introducción. La caracterización de cultivares de Rubus spp. tolerantes al estrés hídrico en campos experimentales es complicado por la dificultad de controlar los factores externos del medio ambiente donde son instalados. La inducción de estrés in vitro es una herramienta eficiente para estudiar los mecanismos de respuesta de las plantas y se emplea en los programas de mejoramiento para la selección de genotipos tolerantes al estrés hídrico. Objetivo. Evaluar la respuesta morfológica y fisiológica in vitro de los explantes en tres cultivares y la accesión silvestre de Rubus spp. bajo condiciones de estrés hídrico simulado con manitol. Materiales y métodos. El estudio se realizó en el Laboratorio de Biología de la Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Perú, durante el año 2020. Se empleó un diseño completamente al azar con arreglo factorial (Factor A: cuatro genotipos y Factor B: potenciales hídricos simulados con manitol: 0, -0,2, -0,3 y -0,4 MPa) y cuatro explantes por unidad experimental. Resultados. Los cultivares respondieron de manera distinta bajo estrés hídrico simulado con manitol. Los cultivares Navaho y Tupy registraron mayor tolerancia. Conclusión. Los rasgos morfológicos y fisiológicos relacionados con la longitud de raíz, el contenido hídrico de brote, raíz y hoja permitieron identificar cultivares de Rubus spp. tolerantes al estrés hídrico simulado con manitol en la fase vegetativa.
Centro de Desarrollo para la Pequeña Empresa. Revisión Sistemática de la Literatura
Authors: Vargas-Morúa Gioconda 
Published: December 2021

El propósito de este artículo es estudiar científicamente la actividad y los alcances de los Centros para el Desarrollo de la Pequeña Empresa (SBDC), a través de una revisión sistemática de la literatura. Para tal fin, se realiza una búsqueda booleana y se extrae la información de tres bases de datos: Scopus, SSCI y EBSCOhost. Los objetivos específicos son: identificar las diferentes perspectivas teóricas que caracterizan y definen la literatura relacionada con los SBDC y destacar las conexiones entre ellas; determinar la perspectiva a la que los investigadores le han otorgado mayor importancia de acuerdo con un análisis de tendencias de las publicaciones; identificar los mayores exponentes del tema e identificar las fuentes que mayormente son consultadas. Para obtener la información bibliométrica se utilizaron técnicas de citación para seleccionar, analizar e interpretar los patrones dentro de la literatura. Se logra: identificar el desarrollo de negocios y la educación empresarial como las dos principales perspectivas teóricas; se establece la educación empresarial como la perspectiva de mayor importancia dado su crecimiento; se reconocen los mayores exponentes, y fuentes que publican el tema. Desde un aspecto práctico, esta investigación contribuye al análisis de la teoría existente sobre SBDC y evidencia la efectividad de estos.