bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance analysis and reliability estimation of five‐level rectifier
Authors: Barwar Manish Kumar , Sahu Lalit Kumar , Bhatnagar Pallavee , Gupta Krishna Kumar , Chander Allamsetty Hema 
Published: November 2021

AbstractMultilevel rectifiers (MLRs) have been gaining popularity in a variety of applications due to their many advantages over two‐level rectifiers such as reduced voltage stress on power switches, much better harmonic profile of the input waveform, reduced dv/dt stress, possibility of fault tolerant operation, and so on. The use of higher number of semiconductor devices which are relatively more prone to faults plays a crucial role in determining the reliability of the system. In recent literature the performance analysis of the MLR in terms of cost, efficiency, reliability, and voltage stress has been majorly ignored. A five‐level rectifier topology with self‐voltage balancing capability has been implemented in this paper. The implemented topology has the capability to maintain the unity power factor (UPF) in all operating conditions. The in‐depth performance analysis in terms of reliability, efficiency and cost has been carried out to establish the suitability of the implemented topology for real‐time applications. In addition, the effect of various parameters on reliability has also been investigated. The MLR topology has been validated through experimentation. A qualitative and quantitative comparison of the proposed work with state‐of‐art has also been presented.
Impact of COVID‐19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV‐HF‐SIRIO 6 study)
Authors: Kubica Jacek , Ostrowska Małgorzata , Stolarek Wioleta , Kasprzak Michał , Grzelakowska Klaudyna , Kryś Jacek , Kubica Aldona , Adamski Piotr , Podhajski Przemysław , Navarese Eliano Pio , Anielska‐Michalak Edyta , Brycht Oliwia , Curzytek Andrzej , Dudek Aneta , Gromadziński Leszek , Grzelakowski Paweł , Kamiński Leszek , Kleinrok Andrzej , Kostkiewicz Marcin , Koziński Marek , Król Paweł , Kulawik Tomasz , Minczew Gleb , Mindykowski Marcin , Pawlak Agnieszka , Prokopczuk Janusz , Skonieczny Grzegorz , Sobkowicz Bożena , Sowiński Sergiusz , Stankala Sebastian , Szymański Paweł , Wester Andrzej , Wilczewski Przemysław , Bartuś Stanisław , Budaj Andrzej , Gąsior Mariusz , Gruchała Marcin , Drożdż Jarosław , Jaguszewski Miłosz , Jankowski Piotr , Legutko Jacek , Lesiak Maciej , Leszek Przemysław , Mitkowski Przemysław , Nessler Jadwiga , Tomaszuk‐Kazberuk Anna , Tycińska Agnieszka , Zdrojewski Tomasz , Kaźmierczak Jarosław 
Published: November 2021

AbstractAimsThe coronavirus disease‐2019 (COVID‐19) pandemic has changed the landscape of medical care delivery worldwide. We aimed to assess the influence of COVID‐19 pandemic on hospital admissions and in‐hospital mortality rate in patients with acute heart failure (AHF) in a retrospective, multicentre study.Methods and resultsFrom 1 January 2019 to 31 December 2020, a total of 101 433 patients were hospitalized in 24 Cardiology Departments in Poland. The number of patients admitted due to AHF decreased by 23.4% from 9853 in 2019 to 7546 in 2020 (P < 0.001). We noted a significant reduction of self‐referrals in the times of COVID‐19 pandemic accounting 27.8% (P < 0.001), with increased number of AHF patients brought by an ambulance by 15.9% (P < 0.001). The length of hospital stay was overall similar (7.7 ± 2.8 vs. 8.2 ± 3.7 days; P = not significant). The in‐hospital all‐cause mortality in AHF patients was 444 (5.2%) in 2019 vs. 406 (6.5%) in 2020 (P < 0.001). A total number of AHF patients with concomitant COVID‐19 was 239 (3.2% of AHF patients hospitalized in 2020). The rate of in‐hospital deaths in AHF patients with COVID‐19 was extremely high accounting 31.4%, reaching up to 44.1% in the peak of the pandemic in November 2020.ConclusionsOur study indicates that the COVID‐19 pandemic led to (i) reduced hospital admissions for AHF; (ii) decreased number of self‐referred AHF patients and increased number of AHF patients brought by an ambulance; and (iii) increased in‐hospital mortality for AHF with very high mortality rate for concomitant AHF and COVID‐19.
Trends in survival of Swedish men and women with heart failure from 1987 to 2014: a population‐based case–control study
Authors: Björck Lena , Basic Carmen , Lundberg Christina E. , Sandström Tatiana Zverkova , Schaufelberger Maria , Rosengren Annika 
Published: November 2021

AbstractAimsTo compare trends in short‐term and long‐term survival of patients with heart failure (HF) compared with controls from the general population.Methods and resultsWe used data from the Swedish National Inpatient Registry to identify all patients aged ≥18 years with a first recorded diagnosis of HF between 1 January 1987 and 31 December 2014 and compared them with controls matched on age and sex from the Total Population Register. We included 702 485 patients with HF and 1 306 183 controls. In patients with HF aged 18–64 years, short‐term (29 days to 6 months) and long‐term mortality (>11 years) decreased from 166 and 76.6 per 1000 person‐years in 1987 to 2000 to 99.6 and 49.4 per 1000 person‐years, respectively, in 2001 to 2014. During the same period, mortality improved marginally, in those aged ≥65 years: short‐time mortality from 368.8 to 326.2 per 1000 person‐years and long‐term mortality from 219.6 to 193.9 per 1000 person‐years. In 1987–2000, patients aged <65 years had more than three times higher risk of dying at 29 days to 6 months, with an hazard ratio (HR) of 3.66 [95% confidence interval (CI) 3.46–3.87], compared with controls (P < 0.0001) but substantially higher in 2001–2014 with an HR of 11.3 (95% CI 9.99–12.7, P < 0.0001). HRs for long‐term mortality (6–10 and >11 years) increased moderately from 2.49 (95% CI 2.41–2.57) and 3.16 (95% CI 3.07–3.24) in 1987–2000 to 4.35 (95% CI 4.09–4.63) and 4.11 (95% CI 3.49–4.85) in 2001–2014, largely because survival among controls improved more than that among patients with HF (P < 0.0001).ConclusionsAbsolute survival improved in HF patients aged <65 years, but only marginally so in those aged ≥65 years. Compared with controls, both short‐term and long‐term relative risk of dying increased, especially in younger patients with HF.
A silicon nitride ion sensitive field effect transistor‐based immunosensor for determination of urinary albumin
Authors: Saengdee Pawasuth , Thanapitak Surachoke , Ongwattanakul Songpol , Srisuwan Awirut , Pankiew Apirak , Thornyanadacha Nutthaphat , Chaisriratanakul Woraphan , Jeamsaksiri Wutthinan , Promptmas Chamras 
Published: November 2021

AbstractThe development of an immunosensor‐based biosensor to detect the human serum albumin (HSA) was developed as a low‐cost and label‐free electrical detection through silicon nitride ion‐sensitive field‐effect transistor (Si3N4‐ISFET). This sensor was functionalized using 3‐Aminopropyltriethoxysilane (APTES). The silanized Si3N4‐ISFET surface was covalently linked with antibody against HSA (Anti‐HSA) via glutaraldehyde (GA) to function as an HSA immunosensor for detection of HSA. The interaction between HSA and Anti‐HSA on this device is monitored by changing of the gate potential at a constant drain current of 50 μA. The relationship between HSA concentration and the gate potential change of HSA immunosensor is linear up to 500 μg/ml with a detection limit of 5 μg/ml. This HSA immunosensor offers a good precision in both intra‐ and inter‐assay with a relative standard deviation of 6.61%, 7.48%, 10.69%, and 9.67%, 13.16%, 15.52% for 100, 200, and 400 μg/ml. The average percentage of recovery assay for the concentration of 32.1, 102.1, and 202.1 μg/ml is 96.55%. This sensor also provides its satisfactory selectivity when testing with Bence Jones protein solution. In addition, the results that was done by this HSA immunosensor is similar to the conventional method using immunoturbidimetric detection with a linear regression of 0.99; n = 40 with a paired sample t‐test of <0.01. Thus, this HSA immunosensor could be applied to urinary microalbumin detection because of its simplicity and satisfactory correlation value.
Ant colony‐based strategy to mitigate the pilot contamination problem in multicell massive multiple‐input multiple‐output systems
Authors: Belhabib Abdelfettah , Zeroual Abdelouhab , Hassani Moha M'Rabet 
Published: November 2021

AbstractDue to its ability to serve a large number of the user equipments (UEs), massive multiple‐input multiple‐output (mMIMO) technology has been elected to meet the requirement of the upcoming new five‐generation systems. Despite its advantages, mMIMO is still obstructed by the pilot contamination (PC) problem, which is birth from, simultaneously, reusing the same orthogonal pilot sequences (OPSs) across several cells. Due to the scarcity of the OPSs, it is necessary to properly allocate the available OPSs to the UEs. Specifically, the available OPSs should be assigned to the UEs while the severity of the PC problem, between the UEs that employ the same pilot sequences, remains as small as possible. To reach that goal, we have employed the ant colony‐based optimization (ACO) algorithm to find the best pattern in which the severity of the PC problem is reduced among all the UEs. In a nutshell, a graph that sizes the strength of the PC among the UEs is constructed; therefore, the ACO algorithm is employed to connect every two UEs that causes to each other the highest influence of the PC, therefore, the UEs are, successively, assigned with the available OPSs where the severity of the PC is significantly reduced.
Highly Efficient Capacitive Deionization Enabled by NiCo4MnO8.5 Electrodes
Authors: Wang Wei , Liu Zhenzhen , Zhang Zehao , Li Haibo 
Published: November 2021

AbstractThe shortage of fresh water resources is one of the major challenges facing this planet. Capacitive deionization (CDI) techniques that are deemed to be highly efficient and require low capital cost have attracted widespread attention in the last few decades. In this work, the cubic ternary metal oxides NiCo4MnO8.5 (Ni–Co–Mn–O) are synthesized by facile hydrothermal method for enhanced symmetrical CDI. Electrochemical measurements illustrate that the Ni–Co–Mn–O possesses low internal resistance and ion diffusion impedance. As a result, the salt removal capacity of the Ni–Co–Mn–O electrode increases from 26.84 to 65.61 mg g−1 by varying the voltage from 0.8 to 1.4 V in 1.0 × 10−2 m NaCl solution, while the charge efficiency stabilizes at ≈80%. After 20 cycles, the capacitance retained is 64.27%, which is due to the irreversibility of Co2+/Co3+ and Mn2+/Mn3+ and the release of Ni3+ from the Ni–Co–Mn–O electrode after long desalination/salination cycles.
Hurricane Florence (2018): Long duration single‐ and dual‐Doppler observations and wind retrievals during landfall
Authors: Biggerstaff Michael I. , Alford A. Addison , Carrie Gordon D. , Stevenson Jeffrey A. 
Published: November 2021

AbstractA ground‐based C‐band Shared Mobile Atmospheric Research and Teaching (SMART) polarimetric radar and the National Weather Service WSR‐88D radar near Wilmington, North Carolina simultaneously observed Hurricane Florence (2018) as it made landfall as a category 1 hurricane. The slow translation of Florence allowed for more than 30 hr of data collection before, during and after the tropical cyclone came ashore. Nearly 26 hr of three‐dimensional wind retrievals every 6–10 min were constructed from the radar observations, providing an unprecedented view of the evolution of rainbands, the inner core and the eyewall of Hurricane Florence. This article describes the radar data, the procedures used for automated quality control, data processing and the wind retrievals that have been constructed. The location of the data and wind retrieval archive is given. These data can be used to study the dynamics and rainfall of Hurricane Florence, to quantify the impact of winds on the natural and built environment, to validate numerical simulations of the tropical cyclone, and as an educational resource for courses in radar and tropical meteorology.
Prospective analysis of serum prolactin levels, clinical symptomatology and sexual functions in patients with schizophrenia switched to paliperidone palmitate 3‐monthly from paliperidone palmitate 1‐monthly: Preliminary findings of the first 3 months
Authors: Karslioğlu Ersin Hatice , Kolcu Zeynep , Karslioğlu Nisa İrem , Çayköylü Ali 
Published: November 2021

AbstractObjectiveLong‐acting injectable (LAI) antipsychotics were developed to improve adherence to schizophrenia treatment. Paliperidone palmitate (PP) has two LAI forms: Monthly (PP1M) and three‐monthly (PP3M). PP3M shows less difference in Peak‐to‐Trough drug concentration levels. This could be related to a lower incidence of hyperprolactinemia, which may negatively affect adherence. We aimed to compare prolactin levels and investigate relationships between prolactin levels, symptomatology and sexual function in patients with schizophrenia after switching from PP1M to PP3M.MethodsTwenty‐five patients were enrolled. The sociodemographic data form, the Positive and Negative Syndromes Scale (PANSS) and the Arizona Sexual Experience Scale (ASEX) were used. Morning blood samples were drawn to determine prolactin levels.ResultsProlactin level (p < 0.001), the total score and arousal sub‐score of ASEX (respectively; p = 0.015, p = 0.020) and the total score and positive scale of PANSS (respectively; p = 0.017, p = 0.021) were decreased on the 90th day (±15 days).ConclusionsAfter switching to PP3M, the decreases in prolactin levels and potentially related sexual side effects was statistically significant. There may be a difference between two formulations of the same drug in terms of side effects, and there is a need for prospective follow‐up studies with larger samples.
Pulmonary disease diagnosis using African vulture optimized weighted support vector machine approach
Authors: Manickam Muruganantham , Siva Rathinavelayutham , Prabakeran Saravanan , Geetha Kannan , Indumathi Varadharajan , Sethukarasi Thirumaaran 
Published: November 2021

AbstractPulmonary disease is a kind of disease that affects the lungs and other parts of the respiratory system and is mainly caused by smoking, asbestos, secondhand smoke, and other forms of air pollutants. Several types of pulmonary diseases are emphysema, fibrosis, pneumothorax, asthma, lung cancer, chronic obstructive pulmonary disease (COPD), and so on. Pulmonary diseases are otherwise known as lung disorders and respiratory diseases. Pulmonary diseases are predicted by several methods using x‐ray images and CT scan images. Some of the recent works predict only a specific disease, and optimal prediction is not yet achieved. Hence, we proposed a novel method known as African vulture optimization (AVO) algorithm‐based weighted support vector machine approach (w‐SVM). The proposed method in this article predicts emphysema, fibrosis, pneumothorax, and normal kinds from the NIH chest x‐ray dataset. The X‐images are preprocessed after data acquisition to obtain the desired size and to remove undesirable noise. The preprocessed images are then sent into the SVM for feature extraction, and the AVO is used to improve the SVM so that a kernel function may be obtained. The proposed w‐SVM effectively predicts the emphysema, fibrosis, pneumothorax, and normal classes from the dataset. The experimental analyses are conducted and compared with existing works and concluded that the proposed work outperforms other approaches in terms of accuracy, sensitivity, specificity, and Matthews's correlation coefficient, prediction time, and modeling time.
Removing dynamic distortions from laser speckle flowgraphy using Eigen‐decomposition and spatial filtering
Authors: Lu Yiming , Wang Ruikang K. 
Published: November 2021

AbstractLaser speckle flowgraphy (LSFG) has been widely used in the investigation of blood flows in ophthalmology. However, the dynamic changes of the ocular optics can impose artificial contrasts to the LSFG, corrupting the detection of both retinal vasculature and blood pulsation at the posterior segment of the human eye. In this study, we propose to use Eigen‐decomposition method to separate the spatially and temporally varying speckle patterns from the static tissues. Spatial filtering is further applied to remove the distortion‐correlated modulation of the speckle patterns. We experimentally show that with the proposed method, the integrity of blood vessels is significantly improved and the distortions in pulse waveforms can be well corrected.
Risk of Osteonecrosis of the Jaw Under Denosumab Compared to Bisphosphonates in Patients With Osteoporosis
Authors: Everts-Graber Judith , Lehmann Daniel , Burkard John-Patrik , Schaller Benoît , Gahl Brigitta , Häuselmann HansJörg , Studer Ueli , Ziswiler Hans-Rudolf , Reichenbach Stephan , Lehmann Thomas 
Published: November 2021

ABSTRACT
Osteonecrosis of the jaw (ONJ) is a rare but serious adverse event associated with antiresorptive treatment. There is little evidence regarding the incidence of ONJ among patients with osteoporosis who are treated with denosumab versus bisphosphonates (BPs). The aim of this study was to determine the risk of ONJ in a real-world population. Subjects who underwent at least one dual-energy X-ray absorptiometry (DXA) examination were included in the osteoporosis register of the Swiss Society of Rheumatology between January 1, 2015, and September 30, 2019. Statistical analyses included incidence rates, rate ratios, and hazard ratios for ONJ, considering sequential therapies and drug holidays as covariates. Among 9956 registered patients, 3068 (89% female, median age 69 years [63 to 76]) were treated with BPs or denosumab for a cumulative duration of 11,101 and 4236 patient-years, respectively. Seventeen cases of ONJ were identified: 12 in patients receiving denosumab at the time of ONJ diagnosis and 5 in patients receiving oral or intravenous BP therapy. The diagnosis of ONJ was confirmed by independent and blinded maxillofacial surgeons, using the American Association of Oral and Maxillofacial Surgeons case definition of ONJ. The incidence of ONJ per 10,000 observed patient-years was 28.3 in patients receiving denosumab and 4.5 in patients with BP-associated ONJ, yielding a rate ratio of 6.3 (95% confidence interval [CI] 2.1 to 22.8), p &lt; 0.001. Nine of 12 patients who developed ONJ during denosumab treatment had been pretreated with BPs, but none of the 5 patients with BP-related ONJ had previously received denosumab. The risk of ONJ was higher in patients receiving denosumab therapy compared with BPs (hazard ratio 3.49, 95% CI 1.16 to 10.47, p = 0.026). Previous BP therapy before switching to denosumab may be an additional risk factor for ONJ development. © 2021 American Society for Bone and Mineral Research (ASBMR).
Aberrant expression profiles and bioinformatic analysis of CAF‐derived exosomal miRNAs from three moderately differentiated supraglottic LSCC patients
Authors: Wu Chunping , Wang Mei , Huang Qiang , Guo Yang , Gong Hongli , Hu Chunyan , Zhou Liang 
Published: November 2021

AbstractBackgroundAberrant expression of exosomal miRNAs has emerged as a research hotspot. However, no studies have been conducted on the dysregulation of exosomal miRNAs derived from cancer‐associated fibroblasts (CAFs) in supraglottic laryngeal squamous cell carcinoma (SLSCC).MethodsCancer‐associated fibroblasts and paired normal fibroblasts (NFs) from SLSCC patients were cultured, and exosomes in the culture supernatants were collected and identified. Exosomal miRNA expression was compared in each pair of CAFs and NFs by next‐generation sequencing, and expression of selected exosomal miRNAs was validated by reverse transcription‑quantitative PCR. Four online bioinformatic algorithms predicted the potential target genes of aberrantly expressed miRNAs, while gene ontology and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment and network analysis identified downstream target genes and their interactions.ResultsThree pairs of CAFs and NFs were successfully cultured and purified. CAF‐derived exosomal miRNAs were mostly downregulated and included miR‐656‐3p, miR‐337‐5p, miR‐29a‐3p and miR‐655‐3p; however, some, including miR‐184‐3p, miR‐92a‐1‐5p, miR‐212‐3p and miR‐3135b, were upregulated. Bioinformatics analysis revealed involvement of these miRNAs in biological processes, cellular components and molecular functions. KEGG analysis revealed the top 30 pathways involvement in cancer initiation and progression and in cell cycle regulation. An interaction network showed miR‐16‐5p, miR‐29a‐3p, miR‐34c‐5p, miR‐32‐5p and miR‐490‐5p as the top five miRNAs and CCND1, CDKN1B, CDK6, PTEN and FOS as the top five target genes.ConclusionsSLSCC patients showed aberrant expression of CAF‐derived exosomal miRNAs. The top five miRNAs and their target genes may jointly constitute a carcinogenic tumour microenvironment and act as biomarkers for SLSCC intervention.
Associations of gender, race, and ethnicity with disparities in short‐term adverse outcomes after pancreatic resection for cancer
Authors: Pastrana Del Valle Jonathan , Mahvi David A. , Fairweather Mark , Wang Jiping , Clancy Thomas E. , Ashley Stanley W. , Urman Richard D. , Whang Edward E. , Gold Jason S. 
Published: November 2021

AbstractBackgroundSeveral studies have identified disparities in pancreatic cancer treatment associated with gender, race, and ethnicity. There are limited data examining disparities in short‐term adverse outcomes after pancreatic resection for cancer. The aim of this study is to evaluate associations of gender, race, and ethnicity with morbidity and mortality after pancreatic resection for malignancy.MethodsThe American College of Surgeons National Surgical Quality Improvement database was retrospectively reviewed. The χ2 test and Student's t‐test were used for univariable analysis and hierarchical logistic regression for multivariable analysis.ResultsMorbidity and major morbidity after pancreaticoduodenectomy are associated with male gender, Asian race, and Hispanic ethnicity, whereas 30‐day mortality is associated with the male gender. Morbidity and major morbidity after distal pancreatectomy are associated with the male gender. Morbidity after pancreaticoduodenectomy is independently associated with male gender, Asian race, and Hispanic ethnicity; major morbidity is independently associated with male gender and Asian race, and mortality is independently associated with Hispanic ethnicity.ConclusionsGender, race, and ethnicity are independently associated with morbidity after pancreaticoduodenectomy for cancer; gender and race are independently associated with major morbidity; and ethnicity is independently associated with mortality. Further studies are warranted to determine the basis of these associations.