bluuebunny/crossref_metadata_2025_split huggingface dataset:
The practice of online assessment in an EFL context amidst COVID-19 pandemic: views from teachers
Authors: Ghanbari Nasim , Nowroozi Sima 
Published: December 2021

AbstractFor many years, technology has been applied to improve the quality of language learning and teaching. However, the outbreak of COVID-19 pandemic accelerated the integration of technology in different language learning contexts. The sudden shift to online teaching faced educators with an array of challenges they had not experienced before. In particular, the teachers encountered many barriers with the online assessment of the students. To shed more light on what passed, following a qualitative mode of inquiry, the present study set out to find out how a group of 20 Iranian English language teachers at Persian Gulf University faced with the online assessment challenges posed by COVID-19. For this aim, the researchers conducted in-depth semi-structured retrospective interviews with the teachers at different times throughout the course. In addition, the teachers were asked to provide a narrative account of how they responded to the crisis. The analysis of the findings showed that after the shift to online assessment, the teachers initially faced with serious pedagogical, technical, administrative, and affective barriers, but as the course proceeded, they could adjust their practice with the new situation. However, the teachers recounted problems that still remained and negatively affected their practice. Overall, the study discusses that to improve the online assessment in the post-COVID-19 era several technological, pedagogical, and administrative measures should be taken into account. These would further improve the integration of the technology in the pedagogical context in the long run.
Prevalence of Schistosoma mansoni infection among children in Ethiopia: a systematic review and meta-analysis
Authors: Bisetegn Habtye , Eshetu Tegegne , Erkihun Yonas 
Published: December 2021

Abstract
Background
Schistosomiasis is a neglected tropical disease caused by mainly Schistosoma mansoni and Schistosoma hematobium. The disease is very common in Africa including Ethiopia. Schistosoma mansoni is a major public health problem in Ethiopia especially among children. This review is aimed to indicate the prevalence of Schistosoma mansoni among children at the national and regional levels.

Methods and material
The PRISMA guidelines were followed. An electronic search of PubMed, Google Scholar, Web of Science, Scopus, MEDLINE, and Google search were carried out using key terms. Articles published from the proceeding of professional associations such as the Ethiopian medical laboratory association, the Ethiopian public health association, and annual national research conferences were also searched to find additional eligible studies. Data were extracted independently by two investigators, and cross-checked by a third reviewer. The quality of included studies was assessed using JBI quality assessment criteria. Data were extracted using Microsoft excel and finally analyzed using STATA version 12. The pooled prevalence was done using a random-effects model.

Result
Overall 49 studies involving 20,493 children (10,572 male and 9, 921 females) were included in this meta-analysis. The pooled prevalence of Schistosoma mansoni infection was 37.13% (95%CI:30.02–44.24). High heterogeneity was observed with I2 of 99.4%, P < 0.000. According to subgroup analysis, the pooled prevalence was high in the SNNPR (41.49%: 95%CI: 19.52–63.46) followed by the Amhara region (41.11%: 95%CI: 30.41–51.8), the Tigray region (31.40%: 95%CI:11.72–51.09), and the Oromia region (28.98%: 95%CI: 18.85–39.1). Year from 2011 to 2015 contributed to the highest prevalence of Schistosoma mansoni infection among children (46.31%: 95%:34.21–59.05).

Conclusion
This study revealed a 37.13% prevalence of Schistosoma mansoni infection among children. This is an alert to improve and implement appropriate control strategies such as mass drug administration in Ethiopia.
Role of PET/CT in initial evaluation of lymphoma patients
Authors: Naguib Manar Mohamed , Botros Samer Malak , Louka Amir Louis , Hussein Rasha S. 
Published: December 2021

Abstract
Background
Accurate radiologic assessment of treatment response in lymphoma patients is important to evaluate the effectiveness of treatment and consequently predict the relapse; the value of PET/CT for post-treatment prognosis prediction has been recently investigated. The aim of this study is to highlight the prognostic value of PET-CT metabolic volumetric parameters in the evaluation of lymphoma patients.

Results
Among the included 40 patients, post-treatment SUV, MTV, and TLG were significantly lower in a responsive group than the non-responsive group. % changes of all quantitative PET/CT parameters were significantly higher in the responsive group than the non-responsive group.

Conclusions
This study suggests that pre-treatment PET/CT quantitative measures (except baseline SUVmax) are not conclusive in the prediction of patient response to treatment; however, the ΔSUVmax, ΔMTV, and ΔTLG% from the baseline to the end of therapy could be used in predicting patient response to treatment, determining patient prognosis, and suggesting the relapse.
Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases
Authors: El Jellas Khadija , Dušátková Petra , Haldorsen Ingfrid S , Molnes Janne , Tjora Erling , Johansson Bente B , Fjeld Karianne , Johansson Stefan , Průhová Štěpánka , Groop Leif , Löhr J Matthias , Njølstad Pål R , Molven Anders 
Published: December 2021

Abstract

Context
Maturity onset diabetes of the young, type 8 (MODY8) is associated with mutations in the CEL gene, which encodes the digestive enzyme carboxyl ester lipase. Several diabetes cases and families have in recent years been attributed to mutations in CEL without any functional or clinical evidence provided.

Objective
To facilitate correct MODY8 diagnostics, we screened 2 cohorts of diabetes patients and delineated the phenotype.

Methods
Young, lean Swedish and Finnish patients with a diagnosis of type 2 diabetes (352 cases, 406 controls) were screened for mutations in the CEL gene. We also screened 58 Czech MODY cases who had tested negative for common MODY genes. For CEL mutation-positive subjects, family history was recorded, and clinical investigations and pancreatic imaging performed.

Results
Two cases (1 Swedish and 1 Czech) with germline mutation in CEL were identified. Clinical and radiological investigations of these 2 probands and their families revealed dominantly inherited insulin-dependent diabetes, pancreatic exocrine dysfunction, and atrophic pancreas with lipomatosis and cysts. Notably, hereditary pancreatitis was the predominant phenotype in 1 pedigree. Both families carried single-base pair deletions in the proximal part of the CEL variable number of tandem repeat (VNTR) region in exon 11. The mutations are predicted to lead to aberrant protein tails that make the CEL protein susceptible to aggregation.

Conclusion
The diagnosis of MODY8 requires a pancreatic exocrine phenotype and a deletion in the CEL VNTR in addition to dominantly inherited diabetes. CEL screening may be warranted also in families with hereditary pancreatitis of unknown genetic etiology.
A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing
Authors: Nitahara-Kasahara Yuko , Mizumoto Shuji , Inoue Yukiko U. , Saka Shota , Posadas-Herrera Guillermo , Nakamura-Takahashi Aki , Takahashi Yuki , Hashimoto Ayana , Konishi Kohei , Miyata Shinji , Masuda Chiaki , Matsumoto Emi , Maruoka Yasunobu , Yoshizawa Takahiro , Tanase Toshiki , Inoue Takayoshi , Yamada Shuhei , Nomura Yoshihiro , Takeda Shin'ichi , Watanabe Atsushi , Kosho Tomoki , Okada Takashi 
Published: December 2021

ABSTRACT
Musculocontractural Ehlers-Danlos syndrome (mcEDS) is caused by generalized depletion of dermatan sulfate (DS) due to biallelic pathogenic variants in CHST14 encoding dermatan 4-O-sulfotransferase 1 (D4ST1) (mcEDS-CHST14). Here, we generated mouse models for mcEDS-CHST14 carrying homozygous mutations (1 bp deletion or 6 bp insertion/10 bp deletion) in Chst14 through CRISPR/Cas9 genome engineering to overcome perinatal lethality in conventional Chst14-deleted knockout mice. DS depletion was detected in the skeletal muscle of these genome-edited mutant mice, consistent with loss of D4ST1 activity. The mutant mice showed common pathophysiological features, regardless of the variant, including growth impairment and skin fragility. Notably, we identified myopathy-related phenotypes. Muscle histopathology showed variation in fiber size and spread of the muscle interstitium. Decorin localized diffusely in the spread endomysium and perimysium of skeletal muscle, unlike in wild-type mice. The mutant mice showed lower grip strength and decreased exercise capacity compared to wild type, and morphometric evaluation demonstrated thoracic kyphosis in mutant mice. The established CRISPR/Cas9-engineered Chst14 mutant mice could be a useful model to further our understanding of mcEDS pathophysiology and aid in the development of novel treatment strategies.
Direct evaluation of cohesin-mediated sister kinetochore associations at meiosis I in fission yeast
Authors: Nambu Masashi , Kishikawa Atsuki , Yamada Takatomi , Ichikawa Kento , Kira Yunosuke , Itabashi Yuta , Honda Akira , Yamada Kohei , Murakami Hiroshi , Yamamoto Ayumu 
Published: December 2021

ABSTRACT
Kinetochores drive chromosome segregation by mediating chromosome interactions with the spindle. In higher eukaryotes, sister kinetochores are separately positioned on opposite sides of sister centromeres during mitosis, but associate with each other during meiosis I. Kinetochore association facilitates the attachment of sister chromatids to the same pole, enabling the segregation of homologous chromosomes toward opposite poles. In the fission yeast, Schizosaccharomyces pombe, Rec8-containing meiotic cohesin is suggested to establish kinetochore associations by mediating cohesion of the centromere cores. However, cohesin-mediated kinetochore associations on intact chromosomes have never been demonstrated directly. In the present study, we describe a novel method for the direct evaluation of kinetochore associations on intact chromosomes in live S. pombe cells, and demonstrate that sister kinetochores and the centromere cores are positioned separately on mitotic chromosomes but associate with each other on meiosis I chromosomes. Furthermore, we demonstrate that kinetochore association depends on meiotic cohesin and the cohesin regulators Moa1 and Mrc1, and requires mating-pheromone signaling for its establishment. These results confirm cohesin-mediated kinetochore association and its regulatory mechanisms, along with the usefulness of the developed method for its analysis.
This article has an associated First Person interview with the first author of the paper.
Nursing home-sensitive conditions: analysis of routine health insurance data and modified Delphi analysis of potentially avoidable hospitalizations
Authors: Bohnet-Joschko Sabine , Valk-Draad Maria Paula , Schulte Timo , Groene Oliver 
Published: December 2021

Background: Hospitalizations of nursing home residents are associated with various health risks. Previous research indicates that, to some extent, hospitalizations of this vulnerable population may be inappropriate and even avoidable. This study aimed to develop a consensus list of hospital discharge diagnoses considered to be nursing home-sensitive, i.e., avoidable.Methods: The study combined analyses of routine data from six statutory health insurance companies in Germany and a two-stage Delphi panel, enhanced by expert workshop discussions, to identify and corroborate relevant diagnoses. Experts from four different disciplines estimated the proportion of hospitalizations that could potentially have been prevented under optimal conditions. Results: We analyzed frequencies and costs of data for hospital admissions from 242,236 nursing home residents provided by statutory health insurance companies. We identified 117 hospital discharge diagnoses, which had a frequency of at least 0.1%. We recruited experts (primary care physicians, hospital specialists, nursing home professionals and researchers) to estimate the proportion of potentially avoidable hospitalizations for the 117 diagnoses deemed avoidable in two Delphi rounds (n=107 in Delphi Round 1 and n=96 in Delphi Round 2, effective response rate=91%). A total of 35 diagnoses with high and consistent estimates of the proportion of potentially avoidable hospitalizations were identified as nursing home-sensitive. In an expert workshop (n=16), a further 25 diagnoses were discussed that had not reached the criteria, of which another 23 were consented to be nursing home-sensitive conditions. Extrapolating the frequency and mean costs of these 58 diagnoses to the national German context yielded total potentially avoidable care costs of €768,304,547, associated with 219,955 nursing home-sensitive hospital admissions.Conclusion: A total of 58 nursing home-relevant diagnoses (ICD-10-GM three-digit level) were classified as nursing home-sensitive using an adapted Delphi procedure. Interventions should be developed to avoid hospital admission from nursing homes for these diagnoses.
Determinants of Performance and Structural Relationships of Rice Processing Industry Performance: Resources Based View Approach
Authors: Bahri T. Saiful , Hakim Dedi Budiman , Juanda Bambang , Sahara Sahara 
Published: December 2021

Purpose: Attention to the capacity of rice milling companies is very important because this company is the main business actor that creates added value. This study aims: (1) to identify the determinants of the performance of the rice milling industry based on the Resources Based View (RBV) framework and (2) to formulate the structural relationship that occurs between the resources of rice milling companies on business performance.
Methodology/Approach: RBV framework and formulate the structural relationships that occur between company resources and business performance Through the SEM-PLS method.
Findings: Structurally, the results of the analysis show that the performance of rice mills is directly determined by reputation with the largest path coefficient of 0.856 and is then followed by marketing differentiation 0.184 and human capital 0.1822, while tangible assets directly have a negative relationship (-0.236) but indirectly through the latent variable the reputation as a mediator has a greater (0.558) and significant positive relationship.
Research Limitation/Implication: The research has empirical implications that not all RBV dimensions can predict the performance of the rice industry, especially organizational variables. This illustrates that in reality in the manufacturing industry, organizational function variables do not really affect the produced.
Originality/Value of paper: This article becomes an important for policymakers in Aceh Province to develop the rice milling industry based on the RBV.
Modelling Customer Satisfaction with Food
Authors: Činčalová Simona , Suchánek Petr , Prokop Martin 
Published: December 2021

Purpose: The subject of the article is the relationship between customer satisfaction, loyalty and personality characteristics. It aims to analyse factors that influence customer satisfaction and loyalty, including their mutual relationships. For this purpose, a comprehensive model of customer satisfaction was created.
Methodology/Approach: The research was carried out using a questionnaire survey on a sample of 1,530 customers of food producers (and 103 food business products that were non-durable) corresponding to the Czech population in terms of gender, age and region. The questionnaires were statistically evaluated using Structural equation modelling (SEM).
Findings: The results show that a strong link between standard customer satisfaction factors (perceived quality, perceived value, customer expectation) overshadows the influence of weaker factors (personality). However, this effect is fully demonstrated when these strong factors are filtered out.
Research Limitation/Implication: The paper focuses on foods that are sold through retail intermediaries, which also affect customer satisfaction. It may be different for other types of products and services and for products sold otherwise. It can also be limited to CR, resp. transition economics, ie. that in developed countries it could be different.
Originality/Value of paper: The contribution of the paper is the finding that customer satisfaction is influenced by a personality factors, whose effect is at first glance weaker. It also shows that the factor image can be constructed taking into account the competitive ability of the company as a hybrid and the functionality of the customer loyalty factor influences the way of its construction.
The Impact of Quality Management on Business Performance of Manufacturing Firms: The Moderated Effect of Industry 4.0
Authors: Nguyen Nu , Nguyen Chuong , Nguyen Hieu , Nguyen Van 
Published: December 2021

Purpose: The research aims to investigate the individual quality management (QM) factors impact on business performance in manufacturing firms. We then assess their influence and look at how industry 4.0 affects business performance directly. Furthermore, the study will demonstrate the moderate effect of industry 4.0 on the interaction between QM and business performance.
Methodology/Approach: The authors used two methodologies. The first is qualitative methods, by interviewing experts to develop a realistically appropriate model. The second is quantitative methods, by carrying out the survey and getting 84 observations. This research used the multivariate data analysis technique PLS-SEM to evaluate three measurement models: formative measurement model, reflective measurement model, and structural model.
Findings: The QM was operationalised as a multi–dimensional construct. According to the findings, these individual QM factors significantly affect the organisation’s performance, including customer satisfaction, employee satisfaction and quality performance. Besides, QM and Industry 4.0 have directly impact on performance. The study also shows that industry 4.0 has a positive moderating role in the relationship between QM and business performance.
Research Limitation/Implication: The survey was only done in emerging countries and the sample size is limited. There are other QM and business performance measurement parameters that have not yet to be discussed.
Originality/Value of paper: The study contributes to the QM literature by building a business quality model, in which the role of Industry 4.0 was explored.
When Service Times Depend on Customers’ Delays: A Relationship Between Two Models of Dependence
Authors: Wu Chenguang (Allen) , Bassamboo Achal , Perry Ohad 
Published: December 2021

When Service Times Depend on Customers’ Delays: A Relationship Between Two Models of Dependence Service times of customers often depend on the delay they experience in queue, as was recently demonstrated empirically in restaurants, call centers, and intensive care units. Two forms of dependence mechanisms in service systems with customer abandonment are studied in this paper: First, the service requirement of a customer may evolve while waiting in queue. Second, customers may arrive to the system with an exogenous service and patience time that are stochastically dependent. Because either dependence mechanism can have significant impacts on a system's performance, it should be identified and taken into consideration for performance evaluation and decision-making purposes. However, identifying the source of dependence from observed data is hard because both the service times and patience times are censored due to customer abandonment. Further, even if the dependence is known to be the latter exogenous one, there remains the difficult task of fitting a joint service-patience times distribution to the censored data. In “When Service Times Depend on Customers’ Delays: A Relationship Between Two Models of Dependence”, Wu, Bassamboo, and Perry provide a solution to address these statistical challenges.
An exploration of hydration practices in Maltese residential care homes for older people
Authors: Micallef Francesca , Vella Marisa , Narmaniya Alan Sciberras , Cook Glenda , Thompson Juliana 
Published: December 2021

Background/aims The integral relationship between adequate hydration and good health is widely recognised. Older people with complex needs and frailty can struggle to maintain adequate hydration, with residents in care home settings being at an increased risk of dehydration. The aim of this study was to explore current hydration practices in residential care homes in Malta. Methods An exploratory qualitative approach was adopted to explore staff's views and approaches in supporting residents' hydration. Data was collected via semi-structured, individual and small group interviews with staff from two care homes from the central and southern region of Malta. A process of open coding, followed by axial coding, was used to analyse the data. Peer debriefing was performed throughout, until agreement was reached among the research team about the final themes and sub-themes. Results Three themes emerged from the data: culture of promoting fluid intake; challenges in supporting older people to achieve optimum hydration; hydration practices and approaches. Conclusions A hydration promotion culture was demonstrated through various practices adopted in the care homes. The strong focus on water intake, in response to concerns about consuming sugary beverages, has implications for the promotion of a person-centred approach to hydration care. Inconsistencies in monitoring of fluids and daily recommended targets highlights the importance of policies or guidelines to guide hydration practice. Challenges related to refusal of fluids and language barriers among non-native staff were evident and justify further research is this area.