bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is biventricular vascular coupling a better indicator of ventriculo-ventricular interaction in congenital heart disease?
Authors: Yang Emily L , Kutty Shelby , Soriano Brian D , Mallenahalli Sathish , Ferguson Mark R , Lewin Mark B , Buddhe Sujatha 
Published: April 2021

AbstractBackground:Ventriculo-ventricular interactions are known to exist, though not well quantified. We hypothesised that the ventricular–vascular coupling ratio assessed by cardiovascular MRI would provide insight into this relationship. We also sought to compare MRI-derived ventricular–vascular coupling ratio to echocardiography and patient outcomes.Methods:Children with cardiac disease and biventricular physiology were included. Sanz’s and Bullet methods were used to calculate ventricular–vascular coupling ratio by MRI and echocardiography, respectively. Subgroup analysis was performed for right and left heart diseases. Univariate and multivariate regressions were performed to determine associations with outcomes.Results:A total of 55 patients (age 14.3 ± 2.5 years) were included. Biventricular ventricular–vascular coupling ratio by MRI correlated with each other (r = 0.41; p = 0.003), with respect to ventricle’s ejection fraction (r = −0.76 to −0.88; p < 0.001) and other ventricle’s ejection fraction (r = −0.42 to −0.47; p < 0.01). However, biventricular ejection fraction had only weak correlation with each other (r = 0.31; p = 0.02). Echo underestimated ventricular–vascular coupling ratio for the left ventricle (p < 0.001) with modest correlation to MRI-derived ventricular–vascular coupling ratio (r = 0.43; p = 0.002). There seems to be a weak correlation between uncoupled right ventricular–vascular coupling ratio with the need for intervention and performance on exercise testing (r = 0.33; p = 0.02).Conclusion:MRI-derived biventricular ventricular–vascular coupling ratio provides a better estimate of ventriculo-ventricular interaction in children and adolescents with CHD. These associations are stronger than traditional parameters and applicable to right and left heart conditions.
Expedition turned Invasion: The 1888 Sikkim Expedition through British, Indian and Chinese eyes
Authors: CHENG YI MENG 
Published: April 2021

AbstractA fresh look at the 1888 Sikkim Expedition using both Chinese and English language sources yields very different conclusions from that of previous research on the subject. During the course of policymaking, the British Foreign Office and the British Government of India did not collaborate to devise a plan to invade Tibet; conversely, their aims differed and clashed frequently. During the years leading to war, the largest newspapers in British India gave plenty of coverage to the benefits of trade with Tibet, thus influencing British foreign policy and contributing indirectly to the outbreak of war. The Tibetan army was soundly defeated in the war, while the British troops suffered only light casualties. Although the Tibetan elites remained committed to the war, the lower classes of Tibetan society quickly grew weary of it. During the war, the British made much use of local spies and enjoyed an advantage in intelligence gathering, which contributed greatly to their victory. Finally, although the war was initially fought over trade issues, the demarcation of the Tibetan-Sikkim border replaced trade issues as the main point of contention during the subsequent peace negotiations. During the negotiations, Sheng Tai, the newly appointed Amban of Tibet, tried his best to defend China's interests.
Diet scores and prediction of general and abdominal obesity in the Melbourne collaborative cohort study
Authors: Hodge Allison M , Karim Md Nazmul , Hébert James R , Shivappa Nitin , Milne Roger L , de Courten Barbora 
Published: April 2021

AbstractObjective:To ascertain which of the Alternative Healthy Eating Index (AHEI) 2010, Dietary Inflammatory Index (DII®) and Mediterranean Diet Score (MDS) best predicted BMI and waist-to-hip circumference ratio (WHR).Design:Body size was measured at baseline (1990–1994) and in 2003–2007. Diet was assessed at baseline using a FFQ, along with age, sex, socio-economic status, smoking, alcohol drinking, physical activity and country of birth. Regression coefficients and 95 % CI for the association of baseline dietary scores with follow-up BMI and WHR were generated using multivariable linear regression, adjusting for baseline body size, confounders and energy intake.Setting:Population-based cohort in Melbourne, Australia.Participants:Included were data from 11 030 men and 16 774 women aged 40–69 years at baseline.Results:Median (IQR) follow-up was 11·6 (10·7–12·8) years. BMI and WHR at follow-up were associated with baseline DII® (Q5 v. Q1 (BMI 0·41, 95 % CI 0·21, 0·61) and WHR 0·009, 95 % CI 0·006, 0·013)) and AHEI (Q5 v. Q1 (BMI −0·51, 95 % CI −0·68, −0·35) and WHR −0·011, 95 % CI −0·013, −0·008)). WHR, but not BMI, at follow-up was associated with baseline MDS (Group 3 most Mediterranean v. G1 (BMI −0·05, 95 % CI −0·23, 0·13) and WHR −0·004, 95 % CI −0·007, −0·001)). Based on Akaike’s Information Criterion and Bayesian Information Criterion statistics, AHEI was a stronger predictor of body size than the other diet scores.Conclusions:Poor quality or pro-inflammatory diets predicted overall and central obesity. The AHEI may provide the best way to assess the obesogenic potential of diet.
Parental considerations during complementary feeding in higher income countries: a systematic review of qualitative evidence
Authors: Spyreli Eleni , McKinley Michelle C , Dean Moira 
Published: April 2021

AbstractObjective:Worldwide data suggest a clash between parental complementary feeding practices and recommendations. Understanding the circumstances under which parents form their feeding practices is a crucial step to improve such practices. This paper aimed to systematically review the existing qualitative literature and synthesise the factors that parents take into consideration in relation to complementary feeding.Design:A systematic review was undertaken. Four electronic databases were searched for qualitative studies published after 2001 exploring parental experiences during complementary feeding. A framework that included authors’ outcomes of interest was used to extract and synthesise study findings. The Standards for Reporting Qualitative Research were used to critically assess the included studies.Setting:Upper-middle- and high-income countries.Participants:Parents with a child below the age of 3 years.Results:A total of forty-seven studies met the eligibility criteria and were included in this systematic review. The themes were organised into three main categories: (1) factors related to introduction of complementary foods; (2) factors related to the type of complementary foods and (3) factors related to both timing and type. The selected literature highlights: prevalent baby cues that prompt parents to introduce solid foods; parents’ views on the recommended timing of complementary feeding; factors that drive the choice of complementary foods and perceived value in advice received from health professionals and grandmothers.Conclusions:This systematic review indicates factors that can be barriers to complying with the complementary feeding guidelines, and therefore, its findings are pertinent to improving parental feeding practices through intervention studies and through infant feeding education in a primary care setting.
Four-element pentaband MIMO antenna for multiple wireless application including dual-band circular polarization characteristics
Authors: Saxena Gaurav , Awasthi Y. K. , Jain Priyanka 
Published: April 2021

AbstractIn this article, a meander line-shaped pentaband (2.18–2.24, 2.38–2.46, 2.65–2.70, 3.10–3.32, 3.38–3.46 GHz) four-element multiple-input–multiple-output antenna is presented. The proposed antenna is also circularly polarized in two bands (at 2.2 and 2.4 GHz) with dual-polarization like right-handed at port 1 or 3 and left-handed at port 2 or 4, which is widely used for mobile satellite services (MSS) and Internet of Things applications. This antenna is designed and fabricated with compact size 50 × 70 × 1.6 mm3 on the FR-4 substrate with good diversity performance in pentaband. Simulated results of antenna-like return loss, isolation, and parameters-related diversity have also been tested experimentally in a controlled environment, which is within the permissible limit. The designed antenna will be appropriate for MSS, industrial scientific and medical (ISM), broadband radio services and educational broadband services, WiMAX radio location services, and amateur radio services. Meanwhile, specific absorption rate of the designed antenna has been examined in an empirical environment for the Fresnel radiating near-field applications.
Numerical Simulation and the Underlying Mechanism of a Severe Hail‐Producing Convective System in East China
Authors: Yin Lei , Ping Fan , Xu Huanbin , Chen Baojun 
Published: April 2021

AbstractA severe convective system that produced egg‐sized hail in Jiangsu province in eastern China on April 28, 2015 was simulated using a cloud‐resolving Weather Research and Forecasting model with the spectral bin microphysics scheme. The simulation reproduced the two stages of the convective system: the linear convective system (LCS) and the bow echo system (BES) stages. During the LCS stage, the intensity of updrafts was slightly stronger than that in the BES stage, with abundant supercooled water above the −20°C layer, and graupel and hail mainly generated in this period. The microphysical budget analyses and size distribution characteristics of hail were studied within one cell that produced hail during the LCS. It was suggested that hail mainly formed through water‐graupel collision and increased in size by collecting liquid water. Hail particles with smaller diameter were located around the perimeter of the main updrafts, while larger ones were distributed at the left edge of the updrafts. Trajectories and size growth processes of hailstones within the chosen cell were calculated by a three‐dimensional hail growth model, and it was found that hail originated from the middle levels on the east side of the updrafts, and were transformed westward and downward to the lower levels. They continued to ascend along the left edge of the updrafts and experienced one or more up‐down recycles and fell down to the ground on the west side of the updrafts.
Shallow Convection and Precipitation Over the Southern Ocean: A Case Study During the CAPRICORN 2016 Field Campaign
Authors: Lang F. , Huang Y. , Protat A. , Truong S. C. H. , Siems S. T. , Manton M. J. 
Published: April 2021

AbstractMarine boundary layer clouds and precipitation observed in a sustained period of open mesoscale cellular convection (MCC) over the Southern Ocean (SO) are investigated using Clouds, Aerosols, Precipitation, Radiation, and atmospherIc Composition Over the southeRn oceaN 2016 observations, Himawari‐8 products, and numerical simulations. The shallow convection was characterized by the presence of supercooled liquid water and mixed‐phase clouds in the sub‐freezing temperature range, consistent with earlier in‐situ observations where ice multiplication is found to be active in producing large quantities of ice in open MCC clouds. Ice‐phase precipitation was observed to melt below cloud base with evidence of cold pools produced in a decoupled boundary layer. Convection‐permitting simulations using the weather research and forecasting model were able to reproduce many of the surface meteorological features and their evolution. However, the evolution of the boundary layer height and the degree of decoupling were poorly simulated, along with the absence of cold pools. The observed cloud morphology and microphysical characteristics were also not well reproduced in the control simulation with the Thompson microphysics scheme, where too much supercooled water was simulated in a too homogenous cloud field. Sensitivity experiments with modified microphysical parameters led to a higher production of glaciated clouds and precipitation. Sensitivity experiments with different boundary layer schemes and vertical resolution, however, showed a smaller impact. A bias of ∼4°C in the initial boundary conditions of the sea surface temperature is discussed. This study highlights the challenge of representing the complex physical processes that underpin the cloud, precipitation, and boundary layer characteristics of the open MCC over the SO.
Paediatric research in the times of COVID-19
Authors: Fleming Paul F. , Gale Chris , Molloy Eleanor J. , Faust Saul N. , Costeloe Kate , Juszczak Edmund , Roehr Charles C. 
Published: April 2021

AbstractThe COVID-19 pandemic poses many direct and indirect consequences for children’s health and associated research. Direct consequences include participation of children in COVID-19 research trials, pausing other research in children and the potential implications of a global economic downturn on future research funding. Collaborative and networked research together with streamlined research processes and use of remote technology have been central to efforts by clinicians and scientists around the world and have proved essential for reducing COVID-19 morbidity and mortality.ImpactMaintain streamlined and efficient approaches to research governance and data sharing to facilitate high-quality collaborative research.Ensure early inclusion of children in trials of therapies for diseases that affect all age groups.Paediatric Research Societies should co-ordinate effective processes to define key research questions and develop multinational clinical trials for diagnostics, therapeutics and preventative strategies for infants, children and young people.
Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans
Authors: Hopkins Seth C. , Dedic Nina , Koblan Kenneth S. 
Published: April 2021

AbstractSEP-363856 is a trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A) agonist, currently in Phase 3 clinical trials for the treatment of schizophrenia. Although SEP-363856 activates TAAR1 and 5-HT1A receptors in vitro, an accessible marker of time- and concentration-dependent effects of SEP-363856 in humans is lacking. In rodents, SEP-363856 has been shown to suppress rapid eye movement (REM) sleep. The aim of the current study was to translate the REM sleep effects to humans and determine pharmacokinetic/pharmacodynamic (PK/PD) relationships of SEP-363856 on a measure of brain activity. The effects of SEP-363856 were evaluated in a randomized, double-blind, placebo-controlled, 2-way crossover study of single oral doses (50 and 10 mg) on REM sleep in healthy male subjects (N = 12 at each dose level). Drug concentrations were sampled during sleep to interpolate individual subject’s pharmacokinetic trajectories. SEP-363856 suppressed REM sleep parameters with very large effect sizes (>3) following single doses of 50 mg and plasma concentrations ≥100 ng/mL. Below that effective concentration, the 10 mg dose elicited much smaller effects, increasing only the latency to REM sleep (effect size = 1). The PK/PD relationships demonstrated that REM sleep probability increased as drug concentrations declined below 100 ng/mL over the course of the night. SEP-363856 was generally safe and well tolerated at both doses. The REM sleep-suppressing effects of SEP-363856 provide an accessible marker of brain activity, which can aid in dose selection and help elucidate its therapeutic potential in further clinical trials.
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
Authors: Gudiño Victoria , Pohl Sebastian Öther-Gee , Billard Caroline V. , Cammareri Patrizia , Bolado Alfonso , Aitken Stuart , Stevenson David , Hall Adam E. , Agostino Mark , Cassidy John , Nixon Colin , von Kriegsheim Alex , Freile Paz , Popplewell Linda , Dickson George , Murphy Laura , Wheeler Ann , Dunlop Malcolm , Din Farhat , Strathdee Douglas , Sansom Owen J. , Myant Kevin B. 
Published: April 2021

AbstractCurrent therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during treatment is common, even following patient stratification. Understanding the mechanisms that promote therapy resistance may lead to the development of novel therapeutic options that complement existing treatments and improve patient outcome. Here, we identify RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor treatment. We find that high RAC1B expression in human colorectal cancer is associated with aggressive disease and poor prognosis and deletion of Rac1b in a mouse colorectal cancer model reduces tumourigenesis. We demonstrate that RAC1B interacts with, and is required for efficient activation of the EGFR signalling pathway. Moreover, RAC1B inhibition sensitises cetuximab resistant human tumour organoids to the effects of EGFR inhibition, outlining a potential therapeutic target for improving the clinical efficacy of EGFR inhibitors in colorectal cancer.
Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis
Authors: Ojavee Sven E. , Kousathanas Athanasios , Trejo Banos Daniel , Orliac Etienne J. , Patxot Marion , Läll Kristi , Mägi Reedik , Fischer Krista , Kutalik Zoltan , Robinson Matthew R. 
Published: April 2021

AbstractWhile recent advancements in computation and modelling have improved the analysis of complex traits, our understanding of the genetic basis of the time at symptom onset remains limited. Here, we develop a Bayesian approach (BayesW) that provides probabilistic inference of the genetic architecture of age-at-onset phenotypes in a sampling scheme that facilitates biobank-scale time-to-event analyses. We show in extensive simulation work the benefits BayesW provides in terms of number of discoveries, model performance and genomic prediction. In the UK Biobank, we find many thousands of common genomic regions underlying the age-at-onset of high blood pressure (HBP), cardiac disease (CAD), and type-2 diabetes (T2D), and for the genetic basis of onset reflecting the underlying genetic liability to disease. Age-at-menopause and age-at-menarche are also highly polygenic, but with higher variance contributed by low frequency variants. Genomic prediction into the Estonian Biobank data shows that BayesW gives higher prediction accuracy than other approaches.
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Authors: Della Chiara Giulia , Gervasoni Federica , Fakiola Michaela , Godano Chiara , D’Oria Claudia , Azzolin Luca , Bonnal Raoul Jean Pierre , Moreni Giulia , Drufuca Lorenzo , Rossetti Grazisa , Ranzani Valeria , Bason Ramona , De Simone Marco , Panariello Francesco , Ferrari Ivan , Fabbris Tanya , Zanconato Francesca , Forcato Mattia , Romano Oriana , Caroli Jimmy , Gruarin Paola , Sarnicola Maria Lucia , Cordenonsi Michelangelo , Bardelli Alberto , Zucchini Nicola , Ceretti Andrea Pisani , Mariani Nicolò Maria , Cassingena Andrea , Sartore-Bianchi Andrea , Testa Giuseppe , Gianotti Luca , Opocher Enrico , Pisati Federica , Tripodo Claudio , Macino Giuseppe , Siena Salvatore , Bicciato Silvio , Piccolo Stefano , Pagani Massimiliano 
Published: April 2021

AbstractCancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de novo chromatin state discovery on a library of different patient-derived organoids. By exploring this resource, we unveil a tumor-specific deregulated enhancerome that is cancer cell-intrinsic and independent of interpatient heterogeneity. We show that the transcriptional coactivators YAP/TAZ act as key regulators of the conserved CRC gained enhancers. The same YAP/TAZ-bound enhancers display active chromatin profiles across diverse human tumors, highlighting a pan-cancer epigenetic rewiring which at single-cell level distinguishes malignant from normal cell populations. YAP/TAZ inhibition in established tumor organoids causes extensive cell death unveiling their essential role in tumor maintenance. This work indicates a common layer of YAP/TAZ-fueled enhancer reprogramming that is key for the cancer cell state and can be exploited for the development of improved therapeutic avenues.
How deep ocean-land coupling controls the generation of secondary microseism Love waves
Authors: Le Pape Florian , Craig David , Bean Christopher J. 
Published: April 2021

AbstractWind driven ocean wave-wave interactions produce continuous Earth vibrations at the seafloor called secondary microseisms. While the origin of associated Rayleigh waves is well understood, there is currently no quantified explanation for the existence of Love waves in the most energetic region of the microseism spectrum (3–10 s). Here, using terrestrial seismic arrays and 3D synthetic acoustic-elastic simulations combined with ocean wave hindcast data, we demonstrate that, observed from land, our general understanding of Rayleigh and Love wave microseism sources is significantly impacted by 3D propagation path effects. We show that while Rayleigh to Love wave conversions occur along the microseism path, Love waves predominantly originate from steep subsurface geological interfaces and bathymetry, directly below the ocean source that couples to the solid Earth. We conclude that, in contrast to Rayleigh waves, microseism Love waves observed on land do not directly relate to the ocean wave climate but are significantly modulated by continental margin morphologies, with a first order effect from sedimentary basins. Hence, they yield rich spatio-temporal information about ocean-land coupling in deep water.
Hierarchical nickel valence gradient stabilizes high-nickel content layered cathode materials
Authors: Lin Ruoqian , Bak Seong-Min , Shin Youngho , Zhang Rui , Wang Chunyang , Kisslinger Kim , Ge Mingyuan , Huang Xiaojing , Shadike Zulipiya , Pattammattel Ajith , Yan Hanfei , Chu Yong , Wu Jinpeng , Yang Wanli , Whittingham M. Stanley , Xin Huolin L. , Yang Xiao-Qing 
Published: April 2021

AbstractHigh-nickel content cathode materials offer high energy density. However, the structural and surface instability may cause poor capacity retention and thermal stability of them. To circumvent this problem, nickel concentration-gradient materials have been developed to enhance high-nickel content cathode materials’ thermal and cycling stability. Even though promising, the fundamental mechanism of the nickel concentration gradient’s stabilization effect remains elusive because it is inseparable from nickel’s valence gradient effect. To isolate nickel’s valence gradient effect and understand its fundamental stabilization mechanism, we design and synthesize a LiNi0.8Mn0.1Co0.1O2 material that is compositionally uniform and has a hierarchical valence gradient. The nickel valence gradient material shows superior cycling and thermal stability than the conventional one. The result suggests creating an oxidation state gradient that hides the more capacitive but less stable Ni3+ away from the secondary particle surfaces is a viable principle towards the optimization of high-nickel content cathode materials.