bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Environment on Health: Nurseâ€™s Role
Authors: Vandali Vijayaraddi , Biradar Rekha B 
Published: July 2021

ABSTRACT:Â Human life without environment is not at all possible, recent years due to huge urbanization and rise in technology affecting the health in a worst manner, ultimately we are only the responsible, Objectives :This article focuses to create awareness regarding environmental health problems. This article focuses on the issues, information to environmental health problems including sources of toxicants. The resources for nurses to prevent, minimize, to treat adverse environmental exposures. To draw attention of NGOs and Govt. There are many report (TOI) says that 70% of Indians doesnâ€™t breathe fresh air due to air pollution and not able to get safe drinking/adequate water its due to water pollution and major cause for this is huge increase in population, fastest growing urbanization. Heavy pollution occurred such air, water, food and huge chemicals using for growing crops also the main reason to reduce life-span as well as increase the risk of developing diseases. The nurse plays a pivotal role in prevention of environmental related risk and illness by continuous touch with the community peoples. The Nurse plays a pivotal role in prevention of health problems with regard to environment, primarily should have thorough knowledge about environmental impact in health and prevent. Â Nurse is foremost person who will assist in screening, diagnosis and alleviating health symptoms at the all the levels of health care.
Clinical Effect of Qibai Landslide on Jellyfish Injuries in Qinhuangdao City
Authors: Li Huaian 
Published: July 2021

Objective: To investigate the clinical effects of phlegm and phlegm and magnesium sulfate combined with magnesium sulfate in sea lice in Qinhuangdao City. Methods: A total of 78 patients with sea lice in Qinhuangdao City from June to
May 2018 were enrolled. They were randomly divided into control group (n=39 cases) and observation group (n=39 cases). The control group was treated with magnesium sulfate. The observation group was treated with Qibai Colshi Decoction on the basisof the control group. The effect of the patients was evaluated after 5 days of treatment. The disappearance time of symptoms, inflammatory factors and adverse drug reactions were compared. Results: After treatment, the onset, pain time, skin loss, swelling time and course of treatment were shorter in the observation group than in the control group (P<0.05). The levels of inflammatory factors were lower than those before treatment (P<5). The levels of TNF-a, IL-6, HIS and 5-HT in the observation group were lower than those in the control group (P<0.05). The rash, itching, drug allergy, liver and kidney were observed in the observation group and the control group. There was no significant difference in the incidence of dysfunction and blood pressure (P>0.05). Conclusion: The combination of magnesium sulfate and magnesium sulfate in the treatment of sea lice in Qinhuangdao City can shorten the disappearance of symptoms, reduce the level of inflammatory factors, and increase the incidence of adverse drug reactions. It is worthy of popularization and application.
Gene big data- A Research for Monogenic Hypertension Diagnosis
Authors: Wei Kuangyi 
Published: July 2021

This paper designed a detailed procedure for monogenic hypertension diagnosis by Whole Exome Sequencing (WES) and provided reliable precise medication guidance. Identification of mutated points provides the clinician valuable information for effective individualized therapeutic option. Therapeutic options that specifically restore the pathway disturbed by these point mutations can be selected to give a precise medicinal guidance.
Clinical Study on the Effects of Different Infusion Solutions on Colloid Osmotic Pressure During Major Abdominal Surgery and Perioperative Albumin in Elderly Patients
Authors: Zhao Chunyan , Chen Cibo , Xia Bingchun 
Published: July 2021

Objective: To explore the effects of different infusion schemes on colloid osmotic pressure during major abdominal surgery and perioperative albumin in elderly patients. Methods: 140 elderly patients of 65-80 years old undergoing major abdominal surgery were divided into 4 groups according to the method of random number table , and different proportions of crystals and colloids were given to different groups (group A: whole crystal, group B: crystal-colloid ratio 1 : 1, group C: crystal-colloid ratio 2: 1, Group D: crystal-colloid ratio 1: 2). The plasma colloid osmotic pressure and level of albumin during perioperative period were monitored. Simultaneously observe the arterial blood pH, blood glucose, extubating time of endotracheal tube, postoperative feeding time, et al. Results: The total amount of liquid inputted in the group of whole crystal was 3056ml (3056 ± 253), which was significantly increased compared with other groups (P<0.01). At the same time, the colloid osmotic pressure decreased by 11.9 mmHg (11.9 ± 2.8), which was more obviously decreased than that of the other groups( B group3.9 ± 1.3, C group 1.5 ± 0.3, D group 4.7±2.1). The difference was a statistically significant(P<0.01). On the other day after surgery, the level of albumin decreased by an average of 4.3 g / L (4.5 ± 1.9) compared with that in group B before surgery, and group C decreased by 2.9 g / L (2.9 ± 1.2) in average, which was significantly different (P<0.05) from group A 10.2 g / L (10.2 ± 1.8). There was no statistically significant difference between group A and group D (P>0.05). And the other indexes were not significantly different between the two groups. Conclusion: This study found that different infusion solutions with different crystal-colloid ratios had an effect on perioperative colloid osmotic pressure and level of albumin.
The Factors Affecting the Efficacy of ?-interferon in the Treatment of (CHB)
Authors: Lin Huaide 
Published: July 2021

Objective: To analyze the factors affecting the efficacy of ?-interferon in the treatment of chronic hepatitis B (CHB). Methods: A total of 100 patients with CHB treated in our hospital from June 2018 to June 2019 were selected. All patients were treated with ?-interferon to evaluate the efficacy, and the factors affecting the effect of ?-interferon on CHB were analyzed. Results: After treatment, 54 patients fully responded and 46 patients did not; the levels of white blood cells, HBV DNA, and HBsAg in the complete response group were lower than those in the incompletely response group, and the differences were statistically significant (P <0.05); Multivariate logistic regression analysis found that serum HBV DNA and HBsAg were independent factors affecting the efficacy of ?-interferon in the treatment of CHB (OR> 1, P<0.05). Conclusion: Serum HBV DNA and HBsAg are risk factors that affect the efficacy of ?-interferon in the treatment of CHB. Monitoring the changes of serum HBV DNA and HBsAg levels has important clinical significance for predicting the efficacy.
Study on the Clinical Effect of Dezocine and Remifentanil Combined with Propofol in Anesthesia for Painless Abortion
Authors: Wang Xin 
Published: July 2021

Objective: To investigate the anesthetic effect of dezocine and remifentanil combined with propofol in painless artificial abortion. Methods: 90 cases in total of painless induced abortion in our hospital from May 2017 to May 2020 were retrospectively analyzed, 29 cases of propofol anesthesia (group A), 29 cases of dezocine combined with propofol anesthesia (group B), and 32 cases of remifentanil combined with propofol anesthesia (group C) were compared the anesthesia situation. Results: Compared with the cases in group A, the incidence of pain, body movement and SPO2<90% at the injection site were lower in group B and group C, the use of propofol was reduced, and the VAS scores were lower when the patients begin to awake, and the efficiency was higher than that in group A(P<0.05); there was no statistic difference in the changes of SBP, DBP and HR index data in the operation time, postoperative awake time, and preoperative, intraoperative and postoperative time points of the three groups(P>0.05). Conclusion: Dezocine and remifentanil combined with propofol for painless artificial abortion anesthesia has more significant effect than propofol anesthesia alone, which can relieve patients' pain and reduce the chance of respiratory depression.
Expression of SOX4 in Endometrial Cancer and its Relationship with Clinical-pathological Characteristics in Endometrial Cancer Patients
Authors: Liao Hongli , Lin Peng 
Published: July 2021

Objective: Objective To investigate the expression of SOX4 in endometrial carcinoma tissues and its relationship with clinicopathological features. Methods: The clinical and pathological data of 51 patients with pathologically diagnosed endometrial carcinoma who underwent panhysterectomy in the Wenzhou Central Hospital from March 2017 to March 2019 were retrospectively analyzed. There were 22 cases of type I endometrial carcinoma and 29cases of type ? endometrial carcinoma. The immunohistochemical expression of SOX4 was detected, and its relationship with clinicopathological parameters was analyzed. Results: Compared with the control group, SOX4 in endometrial cancer group increased significantly (P<0.05); High SOX4 expression were closely related to differentiation, clinical stage and lymph node metastasis of endometrial cancer (P<0.05). Conclusion: SOX4 is related to the occurrence and development of EC. SOX4 may be a clinical evaluation index of EC and a reference index for clinical pathological diagnosis, it is helpful for clinicians to better analyze the high risk factors of EC patients and provide new ideas for early diagnosis, prognosis evaluation and targeted treatment of EC.
Clinical Study of Acupotomy Trinity Lysis on Cervical Spondylotic Myelopathy with Liver and Kidney Deficiency Syndrome
Authors: Gao Jianyong , Zhao Yi , Sun Tinglan , Liu Weike , Wang Zhenguo 
Published: July 2021

Objective: To compare the therapeutic effects of acupotomy trinity lysis and traditional acupotomy on cervical spondylotic myelopathy. Methods: A total of 205 patients with cervical spondylotic myelopathy of liver and kidney deficiency syndrome were randomly divided into the experimental group (105 cases) and the control group (100 cases). The experimental group was relaxed with acupotomy in three positions: Heaven (tian), Human (ren) and Earth (di). Traditional acupotomy was used to relax Ashi acupoints of the affected vertebra in the control group. One treatment was conducted in one week, and the duration of one course of treatment was three weeks. The VAS, JOA score and NDI index were observed after treatment. Results: Before and after treatment, the total treatment efficiency of the treatment group was 95.23%, and that of the control group was 80.00%, there was significant difference between the two groups, P<0.05; Before operation, there was no significant difference in JOA score, NDI index score, and VAS score between the treatment group and the control group (P>0.05); there was no significant difference after 1 week (P>0.05), but there were significant differences between the two groups 2 weeks and 3 weeks after operation (P<0.05). Conclusion: Acupotomy trinity lysis is a safe, effective and economical treatment for cervical spondylotic myelopathy.
Renal Tubular Dysgenesis Associated with Compound Heterozygous ACE Mutations
Authors: Liu Yiran , Wang Xueyan 
Published: July 2021

Inherited renal tubular dysgenesis(RTD), a rare, autosomal recessive disorder is caused by mutations in the genes encoding components of the renin-angiotensin pathway: angiotensinogen(AGT), renin (REN), angiotensin-converting enzyme(ACE), and angiotensin ?? receptor type 1(AGTR1). It characterized by the absence or poor development of renal tubules, and associated with oligohydramnios, Potter sequence and neonatal death due to renal or respiratory failure. We report a family with two mutations in the coding region of the ACE gene: a nonsense mutation in exon4 (c.538C>T) and a frameshift deletion at nucleotide 3073 and nucleotide 3074 in exon20(c.3073_3074delTC). The mutations were in the compound heterozygous state causing disease, because each parent had their own mutation.
Effects of Denervation on the Mid-term Results of Knee Joint Functions after Non-resurfaced Total Knee Arthroplasty
Authors: Liu Ningning , Su Huanhuan , Wang Yuanhe , Zhang Yu , Yu Hongjian 
Published: July 2021

Objective: Total knee arthroplasty (TKA) has become an effective treatment modality for end-stage osteoarthritis and rheumatoid arthritis. Postoperative problems such as anterior knee pain affect postoperative patient satisfaction. Patellar denervation has been proposed as a technique to relieve pain, but its efficacy remains controversial. This study evaluated the mid- and long-term effects of patellar denervation on postoperative knee joint functions, hoping to provide better guidance for clinical practice. Methods: This study is a prospective randomized controlled double-blind study. 58 patients undergoing bilateral non-resurfaced total knee arthroplasty were included and randomized into two groups. Both groups underwent total knee arthroplasty while patellar denervation was performed only on the experimental group. Information regarding whether if patellar denervation was performed were withheld from all patients and outcome assessors. All surgeries were performed by the same high-level professional physician, and the post-stable knee prosthesis system (PS Scorpio NRG PS, Stryker) was used during the surgeries. The knee joint functions were evaluated by professional assessors before and after surgery. The evaluation indicators mainly include KSS scoring, Western Ontario and McMaster Universities (WOMAC) scoring and Visual Analogue Scale (VAS), FJS scoring, etc. The follow-up period was 3 years and 5 years after surgery. Results: The experimental group had better KSS and FJS scores than the control group, the difference was statistically significant. There was no significant inter-group difference in WOMAC and VAS scores. Conclusion: The patellar denervation in TKA patients has positive effects on the mid- and long-term recovery of knee joint functions, and the postoperative satisfaction is better.
Perioperative Nursing Observation of Plasma Radiofrequency Ablation for Treatment of Lumbar Intervertebral Disc Herniation
Authors: Sun Hui , Tang Guo , Li Dan , Wang Lei 
Published: July 2021

Objective: To observe and analyze the perioperative nursing effect of plasma radiofrequency ablation for treatment of lumbar disc herniation. Methods: A total of 100 patients with lumbar intervertebral disc herniation received from October 2017 to October 2020 were selected and randomly divided into two groups with 50 cases in each group. The control group received the conventional nursing model and the experimental group received the comprehensive nursing model. The two groups of nursing care were compared on satisfaction, SDS and SAS scores before and after treatment, VAS score and JOA score before and after treatment, and treatment effect. Results: The nursing satisfaction of the experimental group, SDS and SAS scores before and after treatment, VAS score and JOA score before and after treatment, and the treatment effect were better than those of the control group. The difference was statistically significant (P<0.05). Conclusion: The comprehensive nursing model has a significant effect on the perioperative nursing of the treatment of lumbar intervertebral disc herniation by plasma radiofrequency ablation. More popularization and application will help improve the treatment effect.
Role of Fine Management in Maintenance of Deep Venous Indwelling Catheter in Hemodialysis Patients
Authors: Teng Fei 
Published: July 2021

Objective: This paper mainly explores the effect of fine management application in maintenance of deep venous indwelling catheter in hemodialysis patients. Methods: 150 hemodialysis patients with deep venous catheter indwelling in our hospital from December 2019 to September 2020 were divided into routine group and study group. The routine group was given routine nursing, and the study group was given fine management nursing. The nursing effect of the two groups was analyzed. Results: After nursing intervention, the incidence of complications in the study group was 14.66%, which was lower than that in the conventional group (53.33%), and the nursing compliance in the study group (98.66%) was higher than that in the conventional group (89.33%), all P < 0.05. Conclusion: Fine management plays a significant role in the maintenance of deep venous indwelling catheter in hemodialysis patients, which can reduce the occurrence of complications.
Discussion on the Mechanism of Action of High-frequency Drugs for Treating Heart Failure Based on Network Pharmacology
Authors: Lei Feifei , Zhao Mingjun , Wang Haifang , Pan Chao , Shi Xiaoya 
Published: July 2021

Objective: To explore the target and mechanism of Astragalus membranaceus, poria, salvia miltiorrhiza and semen leiocarpa in the treatment of heart failure by network pharmacology. Methods: The active components of traditional Chinese medicine and the target of heart failure were screened by multi-platform, and the standard gene was transformed by Uniprot. CytoCasp 3.6.1 was used to draw the network diagram of traditional Chinese medicine - component - target. Go and KEGG analysis were performed by Metascape. Results: A total of 36 predictive target sites of Radix Astragalus, Fuling poria, Salvia miltiorrhiza and Draba nemorosa were screened for treatment of heart failure, mainly involving nerve and factor pathways: ADRB2, ADRA1B and AChE. Cancer pathway: TP53, TNF; Pathways of inflammation: IL1B, PTSG2, PTSG1; Sex hormone pathway: ESR1, AR, PGR; Others: SCN5A, HIF1A, etc. The results of GO and KEGG enrichment suggested that the treatment of heart failure with the top four drugs involved cancer pathway, calcium signaling pathway, HIF-1 signaling pathway, and involved in blood circulation, cell proliferation and other processes. Conclusion: This study combines the pharmacological studies of Chinese medicine and western medicine to reveal the mechanism of multi-target and multi-channel regulation of body balance in Chinese medicine treatment.
Effect of Cinepazide Maleate Combined with Promethazine Hydrochloride in the Treatment of Emergency Vertigo
Authors: Yi Jun , Zhou Yincai , Cheng Xinghao 
Published: July 2021

Objective: To explore the effect of cinepazide maleate combined with promethazine hydrochloride in the treatment of emergency vertigo. Methods: 48 cases of emergency vertigo patients in our hospital from November 2017 to November 2019 were divided into experimental group (24 cases, treated with cinepazide maleate combined with promethazine hydrochloride) and control group (24 cases, treated with cinepazide maleate). The clinical efficacy, symptom relief time, adverse reactions and quality of life were compared. Results: The total effective rate of the experimental group (95.83%, 23 / 24) was higher than that of the control group (75.00%), The remission time of nausea and vomiting (1.75 ± 0.22) d, vertigo (3.54 ± 0.63) d, deafness and tinnitus (3.47 ± 0.58) d, night sweats (3.05 ± 0.33) d in the experimental group were shorter than those in the control group, P < 0.05; the incidence of adverse reactions in the experimental group (8.33%, 2 / 24) was lower than that in the control group (33.33%, The scores of social function, material life attitude, physical health and psychological function in the experimental group were 59.14 ± 7.23, 54.05 ± 8.04, 53.58 ± 8.86 and 60.11 ± 8.44 respectively, P < 0.05. Conclusion: In the process of clinical treatment of emergency vertigo patients, the combined application of cinepazide maleate and promethazine hydrochloride has definite curative effect, can relieve clinical symptoms in a short time, has less adverse reactions, and improves the quality of life of patients to a certain extent, which is worthy of promotion.
Clinical Observation on the Treatment of Hypertension by Combination of Modified Banxia Baizhu Tianma Decoction and Auricular Acupuncture
Authors: Zhou Renjie , Yang Liping , Zhang Hongxing , Cao Wangbo 
Published: July 2021

Objective: To observe the curative effect of Jiawei Banxia Baizhu Tianma Decoction (BBTD) in combination with auricular acupuncture in the treatment of primary hypertension with phlegm-dampness syndrome. Methods: 120 patients with hypertension were randomly divided into a pure Western medicine treatment control group (referred to as the control group) and an integrated traditional Chinese and Western medicine treatment group (referred to as the treatment group), with 60 cases in each group. The control group was given nifedipine sustained-release tablets orally; the treatment group: nifedipine sustained-release tablets were given on the basis of modified BBTD combined with auricular acupuncture. The treatment course duration of the two groups was 4 weeks. Before and after treatment, the two groups were evaluated for treatment efficacy and quality of life. Results: There is statistically significant difference in blood pressure lowering between the treatment group and the control group (P?0.05); the treatment group was better than the control group in symptoms improvement of the patients (P?0.05); in terms of the improvement in quality of life , the treatment group was significantly better than the control group (P?0.05, P?0.01). Conclusion: Modified BBTD combined with auricular acupuncture method can reduce blood pressure and improve clinical symptoms in patients with primary hypertension with phlegm-dampness syndrome, and significantly improve the quality of life of patients.
Application Effect Evaluation of Telmisartan combined with Spironolactone after Catheter Ablation of Patients with Paroxysmal Atrial Fibrillation
Authors: Zhao Rongcheng , Han Jia , Zhao Lei 
Published: July 2021

Objective: To evaluate the application effect of telmisartan combined with spironolactone after catheter ablation of patients with paroxysmal atrial fibrillation. Methods: 80 cases of patients with paroxysmal atrial fibrillation who received radiofrequency catheter ablation treatment from March 2013 to March 2016 in our hospital were randomly selected, these patients were divided into two groups according to the treatment methods, namely, the telmisartan with Spironolactone treatment group (combined treatment group, n=40) and the conventional therapy group (n=40). The hs-CRP, NT-proBNP, LAD and recurrence of the two groups were analyzed. Results: The hs-CRP, NT-proBNP levels after 3 months of the combined treatment group were significantly lower (P<0.05), the recurrence rate 10.0% (4/40) was significantly lower than the conventional therapy group 27.5% (11/40) (P<0.05), the time to recurrence was significantly longer than the conventional therapy group (P<0.05). Conclusion: The application effects of telmisartan combined with spironolactone after catheter ablation in the treatment of patients with paroxysmal atrial fibrillation are better than conventional therapy.