bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation of the transonic buffet cycle on a supercritical airfoil
Authors: D’Aguanno A. , Schrijer F. F. J. , van Oudheusden B. W. 
Published: October 2021

AbstractTransonic buffet behaviour of the supercritical airfoil OAT15A was investigated experimentally at flow conditions$$Ma=0.7$$Ma=0.7and$$\alpha =3.5^\circ $$α=3.5∘, using schlieren and particle image velocimetry (PIV). The general behaviour of the buffet cycle was characterised with short-exposure schlieren visualisation and phase-averaged PIV measurements. A spectral analysis showed that the shock oscillation occurs with a dominant contribution at 160 Hz (St = 0.07, in good agreement with the literature) and between 25 and 55 % of the chord of the airfoil. Proper Orthogonal Decomposition (POD) was applied to the PIV data to extract the main modes connected with buffet. It is found that the first three most energetic modes capture around 65 % of the total fluctuating kinetic energy. The first and the third modes have a main frequency peak at 160 Hz and are well representing the separated area and the shock oscillation. The second mode was, instead, associated with an asymmetrical behaviour of the separated area and of the shear layer and displays a main peak at 320 Hz, being double the main buffet cycle frequency. Finally, it was shown that by using the 11 most energetic POD modes, an accurate reduced-order model (ROM) is obtained, which when subtracted from the instantaneous velocity fields allows the visualisation of the small-scale structures present in the flow, such as the upstream travelling waves (UTWs) and the vortex shedding in the separated area near the trailing edge. The analysis allowed to estimate the velocity of the UTWs, obtaining values in good agreement with the literature. In contrast, the analysis of the vortex dynamics in the trailing edge area revealed that vortices shed at the shock foot, which convect downstream in an area detached from the airfoil surface, cannot be considered responsible for the creation of UTWs in view of the mismatch in frequency of the two phenomena.Graphic abstract
Cardiac acoustic biomarkers as surrogate markers to diagnose the phenotypes of pulmonary hypertension: an exploratory study
Authors: Yamakawa Nobuhide , Kotooka Norihiko , Kato Tomoyuki , Kuroda Tatsuhiko , Node Koichi 
Published: October 2021

AbstractPulmonary hypertension (PH) is commonly associated with left heart disease. In this retrospective study, using the database of a clinical study conducted between January 2008 and July 2008, the phenotypes of PH were classified using non-invasive cardiac acoustic biomarkers (CABs) and compared with classification by echocardiography. Records with same-day measurement of acoustic cardiography and right heart catheterization (RHC) parameters were included; cases with congenital heart disease were excluded. Using the RHC measurements, PH was classified as pre-capillary PH (Prec-PH), isolated post-capillary PH (Ipc-PH), and combined pre-capillary and post-capillary PH (Cpc-PH). The first, second, third, and fourth heart sounds (S1, S2, S3, and S4) were quantified as CABs (intensity, complexity, and strength). Forty subjects were selected: 5 had Prec-PH, 5 had Ipc-PH, 8 had Cpc-PH, and 22 had No-PH. CABs were significantly correlated with RHC measurements, with significant differences among phenotypes. Phenotype classification was performed using various CABs, and the diagnostic performance as assessed by the area under the receiver operating characteristic curve was 0.674–0.720 for Prec-PH, 0.657–0.807 for Ipc-PH, and 0.742 for Cpc-PH. High negative and low positive predictive values for phenotype identification were observed. CABs may provide an ambulatory measurement method with home-monitoring friendliness which is more convenient than standard examinations to identify presence of PH and its phenotypes.
Surgery due to mechanical bowel obstruction in relapsed ovarian cancer: clinical and surgical results of a bicentric analysis of 87 patients
Authors: Armbrust R. , Chekerov R. , Sander S. , Biebl M. , Chopra S. , Krell Jonathan , Rinne Natasha , Nixon Katherine , Fotopoulou C. , Sehouli J. 
Published: October 2021

Abstract
Introduction
Mechanical bowel obstruction is a frequent acute and life-threatening event in relapsed ovarian cancer. Salvage surgery after failure of all conservative approaches, resulting in short bowel syndrome (SBS) constitutes a therapeutic dilemma. Our aim was to evaluate patients’ surgical and clinical outcome in these highly palliative situations. Previous, limited, data reported a high morbidity and mortality. However, recent surgical and therapeutical improvements in relapsed ovarian cancer (ROC) offer better identification of patients who might benefit from surgery in an effort to extend the window of opportunity to subsequently offer these patients novel systemic therapeutic approaches.

Material and methods
All subsequent ROC patients between 2012 and 2017 with acute mechanical bowel obstruction who underwent salvage extraperitoneal en bloc intestinal resection were retrospectively identified. Data were collected from two ESGO certified Ovarian Cancer Centers of Excellence (Charité Berlin and Imperial College London) and systematically evaluated regarding surgical and clinical outcomes.

Results
Overall, 87 ROC patients were included in the analysis (median age 56 years, range 24–88), 47% were platinum resistant. High grade serous was the most common histology (76%) while most of the patients (67%) had at least two previous lines of treatment. Mean observed OS was 7.8 months. After salvage surgery, 46% of the patients had a residual small bowel length < 180 cm and 18% > 180 cm resulting in 41% in need of total parental nutrition. In 80% of the patients a permanent stoma was necessary. 30d morbidity and mortality was 74% and 10%, respectively. More than half of the patients were able to receive further courses of chemotherapy after surgery.

Discussion
Salvage surgery for bowel obstruction in ROC patients needs careful consideration and identification of optimal surgical candidates to have the maximal therapeutic benefit. Despite the challenging morbidity profile, most patients managed to proceed to subsequent novel and conventional systemic treatment and so have their window of therapeutic opportunity extended.
Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors
Authors: Angius Luca , Pageaux Benjamin , Crisafulli Antonio , Hopker James , Marcora Samuele Maria 
Published: October 2021

Abstract
Purpose
This study investigated the effect of ischemic preconditioning (IP) on metaboreflex activation following dynamic leg extension exercise in a group of healthy participants.

Method
Seventeen healthy participants were recruited. IP and SHAM treatments (3 × 5 min cuff occlusion at 220 mmHg or 20 mmHg, respectively) were administered in a randomized order to the upper part of exercising leg’s thigh only. Muscle pain intensity (MP) and pain pressure threshold (PPT) were monitored while administrating IP and SHAM treatments. After 3 min of leg extension exercise at 70% of the maximal workload, a post-exercise muscle ischemia (PEMI) was performed to monitor the discharge group III/IV muscle afferents via metaboreflex activation. Hemodynamics were continuously recorded. MP was monitored during exercise and PEMI.

Results
IP significantly reduced mean arterial pressure compared to SHAM during metaboreflex activation (mean ± SD, 109.52 ± 7.25 vs. 102.36 ± 7.89 mmHg) which was probably the consequence of a reduced end diastolic volume (mean ± SD, 113.09 ± 14.25 vs. 102.42 ± 9.38 ml). MP was significantly higher during the IP compared to SHAM treatment, while no significant differences in PPT were found. MP did not change during exercise, but it was significantly lower during the PEMI following IP (5.10 ± 1.29 vs. 4.00 ± 1.54).

Conclusion
Our study demonstrated that IP reduces hemodynamic response during metaboreflex activation, while no effect on MP and PPT were found. The reduction in hemodynamic response was likely the consequence of a blunted venous return.
Novel gene discovery for hearing loss and other routes to increased diagnostic rates
Authors: Kremer Hannie 
Published: October 2021

AbstractDespite decades of research, there is much to be learned about the genetic landscape of sensorineural hearing loss. Novel genes for hearing loss remain to be identified while ‘secrets’ of the known genes need to be uncovered. These ‘secrets’ include regulatory mechanisms of gene activity and novel aspects of gene structure. To obtain a more complete picture of the genetics of hearing loss, the available experimental and bioinformatic tools need to be fully exploited. This is also true for data resources such as ENCODE. For the inner ear, however, such data resources and analytical tools need to be developed or extended. Collaborative studies provide opportunities to achieve this and to optimally use those tools and resources that are already available. This will accelerate the discoveries that are necessary for improving molecular genetic diagnostics and genetic counselling and for the development of therapeutic strategies.
Skeleton-based human activity recognition using ConvLSTM and guided feature learning
Authors: Yadav Santosh Kumar , Tiwari Kamlesh , Pandey Hari Mohan , Akbar Shaik Ali 
Published: October 2021

AbstractHuman activity recognition aims to determine actions performed by a human in an image or video. Examples of human activity include standing, running, sitting, sleeping,etc. These activities may involve intricate motion patterns and undesired events such as falling. This paper proposes a novel deep convolutional long short-term memory (ConvLSTM) network for skeletal-based activity recognition and fall detection. The proposed ConvLSTM network is a sequential fusion of convolutional neural networks (CNNs), long short-term memory (LSTM) networks, and fully connected layers. The acquisition system applies human detection and pose estimation to pre-calculate skeleton coordinates from the image/video sequence. The ConvLSTM model uses the raw skeleton coordinates along with their characteristic geometrical and kinematic features to construct the novel guided features. The geometrical and kinematic features are built upon raw skeleton coordinates using relative joint position values, differences between joints, spherical joint angles between selected joints, and their angular velocities. The novel spatiotemporal-guided features are obtained using a trained multi-player CNN-LSTM combination. Classification head including fully connected layers is subsequently applied. The proposed model has been evaluated on the KinectHAR dataset having 130,000 samples with 81 attribute values, collected with the help of a Kinect (v2) sensor. Experimental results are compared against the performance of isolated CNNs and LSTM networks. Proposed ConvLSTM have achieved an accuracy of 98.89% that is better than CNNs and LSTMs having an accuracy of 93.89 and 92.75%, respectively. The proposed system has been tested in realtime and is found to be independent of the pose, facing of the camera, individuals, clothing,etc. The code and dataset will be made publicly available.
Konzepte zur Integration von Flexibilitäten in Wohn- und Nichtwohngebäuden in ein dynamisches Lastmanagement
Authors: Becker Michael , Müller Tobias , Forchheim Maximilian Hendrik , Cano-Tirado David , Zdrallek Markus 
Published: October 2021

ZusammenfassungDieser Artikel stellt die Konzepte zweier Add-on-Systeme für Verteilnetzautomatisierungssysteme vor, deren Ziel die Nutzung neuer Netzaktoren, wie die Ladeinfrastruktur für Elektrofahrzeuge, elektrische Wärmepumpen und Batteriespeicher, als Flexibilitäten für ein dynamisches und marktorientiertes Netzengpassmanagement ist.Die entwickelten Konzepte legen dabei jeweils den Fokus auf den regulierten Bereich des Netzbetreibers (Fokus des Projektes ElCiN) und den freien Marktbereich der Anschlussnehmer (Fokus des Projektes InFleX), ohne die jeweiligen Anforderungen des anderen Bereichs außer Acht zu lassen.Das im ElCiN-Projekt entwickelte Gesamtkonzept, welches den zellularen Ansatz des VDE umsetzt (VDE Verband der Elektrotechnik Elektronik Informationstechnik e.V., Zellulares Energiesystem: Ein Beitrag zur Konkretisierung des zellularen Ansatzes mit Handlungsempfehlungen, https://www.vde.com/resource/blob/1884494/98f96973fcdba70777654d0f40c179e5/studie---zellulares-energiesystem-data.pdf2019), ermöglicht ein vollautomatisiertes und marktorientiertes Netzengpassmanagement. Dabei wurde ein Datenaustausch zwischen reguliertem Bereich und Marktbereich definiert, der einzelne neue Netzaktoren, aber auch in Zellen zusammengefasste und ggf. optimierte Netzaktoren, in das Netzengpassmanagement integrieren kann.Das InFleX-Projekt beschäftigt sich mit der Hebung der Flexibilitäten für (Nicht-) Wohngebäude und deren energetischen Optimierung und Flexibilitätsbereitstellung für Verteilnetzautomatisierungssysteme.Beide entwickelten Konzepte sowie die daraus entstandenen Systeme können grundsätzlich zu einem Gesamtsystem zusammengefasst werden. Ein solches Gesamtsystem setzt dann nicht nur den zellularen Ansatz des VDE um, sondern tut dies unter Berücksichtigung der Anforderungen und Interessen des Netzbetreibers sowie des Anschlussnehmers.
Enhancing learning capabilities of movement primitives under distributed probabilistic framework for flexible assembly tasks
Authors: Wang Likun , Jia Shuya , Wang Guoyan , Turner Alison , Ratchev Svetan 
Published: October 2021

AbstractThis paper presents a novel probabilistic distributed framework based on movement primitives for flexible robot assembly. Since the modern advanced industrial cell usually deals with various scenarios that are not fixed via-point trajectories but highly reconfigurable tasks, the industrial robots used in these applications must be capable of adapting and learning new in-demand skills without programming experts. Therefore, we propose a probabilistic framework that could accommodate various learning abilities trained with different movement-primitive datasets, separately. Derived from the Bayesian Committee Machine, this framework could infer new adapting trajectories with weighted contributions of each training dataset. To verify the feasibility of our proposed imitation learning framework, the simulation comparison with the state-of-the-art movement learning framework task-parametrised GMM is conducted. Several key aspects, such as generalisation capability, learning accuracy and computation expense, are discussed and compared. Moreover, two real-world experiments, i.e. riveting picking and nutplate picking, are further tested with the YuMi collaborative robot to verify the application feasibility in industrial assembly manufacturing.
Acute distal biceps tendon rupture: retrospective analysis of two different approaches and fixation techniques
Authors: Di Stefano Marco , Sensi Lorenzo , di Bella Leonardo , Tucci Raffaele , Bazzucchi Efisio , Zanna Luigi 
Published: October 2021

Abstract
Purpose
The aim of our study is to compare the modified double incision (DI) with bone tunnel reinsertion with the single-incision (SI) double tension slide technique in terms of clinical and functional outcomes and complication rates.

Methods
A retrospective comparative analysis was performed on 65 patients treated for total distal biceps tendon rupture. The surgical technique adopted for each patient was based on the preference of two experienced elbow surgeons. The DASH and MAYO questionnaires, functional outcome and ROM were recorded in all subjects.

Results
Of 65 patients, we collected data of a cohort of 54 distal biceps tendon ruptures that satisfied inclusion criteria. Twenty-five were treated by modified DI and 29 SI techniques. The recovery of the complete ROM in terms of flexion/extension and prono-supination occurred in the 79.6% of the patients, without statistical significant difference between the adopted technique. We reported a complication rate of 12% and 20.7% for DI and SI techniques, respectively, without statistical correlation (P = 0.84). The average DASH score was similar for DI and SI techniques without significant differences (P = 0,848). The Mayo score results were excellent in the majority of the patients. No significant difference in MAYO results was reported comparing the surgical techniques (P = 1).

Conclusion
Both techniques provide a reliable and strong repair with an optimal recovery of ROM returning to preinjury activity with substantially overlapping timelines.
Radiographic imaging in relation to the mandibular third molar: a survey among oral surgeons in Sweden
Authors: Cederhag Josefine , Truedsson Anna , Alstergren Per , Shi Xie-Qi , Hellén-Halme Kristina 
Published: October 2021

Abstract

Objectives
To query the experience of oral surgeons concerning referral routines and preferences for radiographic imaging modality before surgical removal of mandibular third molars and investigate factors that influence imaging modality preferences.

Materials and methods
Members of the Swedish Association of Oral and Maxillofacial Surgeons (n = 280) were invited to participate in a web-based digital survey concerning their experiences and use of three imaging modalities in pre-surgical assessment of mandibular third molar removal. The survey comprised multiple-choice questions and four cases depicted in images; respondents reported whether they would supplement the cases with other images and, if so, from which modality.

Results
The response rate was 64%. Panoramic radiographs were most commonly used in pre-surgical planning (response options: always or often), significant difference between professions (p = 0.039), and considered to facilitate treatment planning (87%), as was CBCT (82%); for 51%, CBCT reduced post-operative complications. Preferred modality for localizing the mandibular canal was fairly evenly distributed and for non-complex case, significant difference between subgroups of OMFS surgeons was found (p = 0.003) as to preference for intraoral radiographs.

Conclusions
A majority of respondents received a report within 2 weeks of their referral for CBCT and would read the report and view the images before surgery. Image modality preference differed depending on case complexity, with a greater perceived need for CBCT. Profession and practical experience affected choice.

Clinical relevance
Choice of imaging modality in mandibular third molar assessment is also important from dose delivery and social economy standpoints.
Phase 2 study of axicabtagene ciloleucel in Japanese patients with relapsed or refractory large B-cell lymphoma
Authors: Kato Koji , Makita Shinichi , Goto Hideki , Kanda Junya , Fujii Nobuharu , Shimada Kazuyuki , Akashi Koichi , Izutsu Koji , Teshima Takanori , Fukuda Natsuko , Sumitani Tokuhito , Sumi Hiroyuki , Shimizu Shinji , Kakurai Yasuyuki , Yoshikawa Kenji , Tobinai Kensei , Usui Noriko , Hatake Kiyohiko 
Published: October 2021

Abstract
Background
Axicabtagene ciloleucel (axi-cel) is an autologous chimeric antigen receptor T-cell based anti-CD19 therapy. The ZUMA-1 study, multicenter, single-arm, registrational Phase 1/2 study of axi-cel demonstrated high objective response rate in patients with relapsed/refractory large B-cell lymphoma. Here, we present the results of the bridging study to evaluate the efficacy and safety of axi-cel in Japanese patients (JapicCTI-183914).

Methods
This study was the phase 2, multicenter, open-label, single-arm trial. Following leukapheresis, axi-cel manufacturing and lymphodepleting chemotherapy, patients received a single infusion of axi-cel (2.0 × 106 cells/kg). Bridging therapy between leukapheresis and conditioning chemotherapy was not allowed. The primary endpoint was objective response rate.

Results
Among 17 enrolled patients, 16 received axi-cel infusion. In the 15 efficacy evaluable patients, objective response rate was 86.7% (95% confidence interval: 59.5–98.3%); complete response/partial response were observed in 4 (26.7%)/9 (60.0%) patients, respectively. No dose-limiting toxicities were observed. Grade ≥ 3 treatment-emergent adverse events occurred in 16 (100%) patients—most commonly neutropenia (81.3%), lymphopenia (81.3%) and thrombocytopenia (62.5%). Cytokine release syndrome occurred in 13 (81.3%) patients (12 cases of grade 1 or 2 and 1 case of grade 4). No neurologic events occurred. Two patients died due to disease progression, but no treatment-related death was observed by the data-cutoff date (October 23, 2019).

Conclusion
The efficacy and safety of axi-cel was confirmed in Japanese patients with relapsed/refractory large B-cell lymphoma who have otherwise limited treatment options.

Trial registration
JapicCTI-183914.
Optimal Population Policy with Health Care and Lethal Pollution
Authors: Lehmijoki Ulla , Palokangas Tapio 
Published: October 2021

AbstractOptimal population policy is examined in the following setup. Families invest in capital, spend on health care and determine their number of children. Firms produce output from labor, capital and pollutants. Pollution increases, but private and public health care decrease mortality dynamically, with lags. Our main findings are the following. A marginal increase in public health care improves welfare as long as it diminishes the mortality rate more than that in private health care. The government can decentralize the social optimum by a parental tax on newborns and a Pigouvian tax on pollutants. Private health care should not be taxed.
A Stackelberg game for the Italian tax evasion problem
Authors: Gambarelli Gianfranco , Gervasio Daniele , Maggioni Francesca , Faccini Daniel 
Published: October 2021

AbstractIn this paper, we consider the problem of tax evasion, which occurs whenever an individual or business ignores tax laws. Fighting tax evasion is the main task of the Economic and Financial Military Police, which annually performs fiscal controls to track down and prosecute evaders at national level. Due to limited financial resources, the tax inspector is unable to audit the population entirely. In this article, we propose a model to assist the Italian tax inspector (Guardia di Finanza, G.d.F.) in allocating its budget among different business clusters, via a controller-controlled Stackelberg game. The G.d.F. is seen as the leader, while potential evaders are segmented into classes according to their business sizes, as set by the Italian regulatory framework. Numerical results on the real Italian case for fiscal year 2015 are provided. Insights on the optimal number of controls the inspector will have to perform among different business clusters are discussed and compared to the strategy implemented by the G.d.F.