bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Monitoring of Chronic Heart Failure in Argentina: Is the Implantable Pulmonary Artery Pressure with CardioMEMS Heart Failure System Cost-effective?
Authors: Alcaraz Andrea , Rojas-Roque Carlos , Prina Daniela , González Juan Martín , Pichon-Riviere Andres , Augustovski Federico , Palacios Alfredo 
Published: April 2021

Abstract
Background. The CardioMEMS® sensor is a wireless pulmonary artery pressure device used for monitoring symptomatic heart failure (HF). The use of CardioMEMS was associated with a reduction of hospitalizations of HF patients, but the acquisition cost could be high in low-and-middle income countries. Evidence of cost-effectiveness is needed to help decision-makers to allocate resources according to “value for money”. This study aimed to estimate the cost-effectiveness of CardioMEMS use in HF patients from the third-party payer perspective -Social Security (SS) and Private Sector (PS)-in Argentina.Methods. A Markov model was developed to estimate the cost-effectiveness of CardioMEMS versus usual medical care, over a lifetime horizon. The model was applied to a hypothetical population of patients with HF functional class III with at least one hospitalization in the previous 12 months. The main outcome was the incremental cost-effectiveness ratio (ICER). To populate the model we retrieved clinical, epidemiological and utility parameters from the literature, whilst direct medical costs were estimated through micro-costing approach (exchange rate USD 1 = ARS 76.95). Uncertainty in all parameters were assessed by deterministic, probabilistic and scenario sensitivity analysis.Results. Compared with the usual medical care, CardioMEMS increased QALY by 0.37 and increased costs per patient by ARS 1,081,703 for SS and ARS 919,051 for PS. The resultant ICER was ARS 2,937,756 per QALY and ARS 2,496,015 per QALY for SS and PS respectively. ICER was most sensitive to the hazard ratio of HF hospital admission and the acquisition price of CardioMEMS. The probability that CardioMEMS is cost-effective at one (ARS 700,473), three (ARS 2,101,419,) and five (ARS 3,502,363) GDP per capita is 0.6%, 17.9% and 64.1% for SS and 5.4%, 33.3% and 73.2% for PS.Conclusions. CardioMEMS was more effective and more costly than usual care in class III HF patients. Since in Argentina there is no current explicit threshold, the final decision to determine its cost-effectiveness will depend on the willingness-to-pay for QALYs in each health subsector.
Has COVID-19 Strengthened Environmental Awareness?
Authors: Lieven Theo 
Published: April 2021

Abstract
Since the beginning of 2020, the COVID-19 pandemic has been a global threat to humankind. In addition to many cases of illness and millions of deaths, the economy has suffered. Not surprisingly, vehicle sales have declined sharply in most countries by up to 25%. Overall, however, sales of electric vehicles (EVs) did not stall but increased to previously forecasted levels. Is this increase evidence that COVID-19 has promoted sustainable action and strengthened environmental awareness, as researchers have discussed in recently published articles? This study examines the causal effect of COVID-19 on environmental concern and behavior by assessing vehicle buyers’ decision process regarding EVs after the outbreak of the COVID-19 pandemic.
Mistletoe Contains Higher Secondary Metabolites Than the Host Plant at the Host-Parasite Interface: Insights From Tapinanthus Globiferus Collected In Enugu, Nigeria
Authors: Ajuziogu Godswill , Agbo G C , Njokuocha Reginald , Nweze Anthony , Ojua Eugene O , Ogujawa Pamela 
Published: April 2021

Abstract
Background: This study aims at evaluating the phytochemicals composition at the host-parasite interfaces of parasitic plant Tapinanthus globiferus (mistletoe) and four host plants. Wood tissues of the hosts and the parasite at the host-parasite interface were collected and analyzed to determine the presence secondary metabolites. Results: The result showed that flavonoids, saponins, and glycosides were present in the plants and parasite samples. The results revealed higher concentration of flavonoids (P < 0.05) in the parasite of C. acuminata (1190.33 ± 48.23 mgQE/g) and P. macrophylla (1482.55 ± 31.35 mgQE/g) than in the host plant. Saponins was significantly (P < 0.05) higher in the parasites as compared to their respective host. Conclusion: At the host-parasite interface, significantly higher phytochemicals in the wood portion of T. globiferus was observed as compared to the host plants wood; however, the variability in phytochemical content of T. globiferus is dependent on the host. Therefore, milestoe would be a better source of bioactive compounds with high medicinal values than their host plants if explored further.
Effect of Non-Deceptive Placebo on Weight Loss: A Preliminary Study
Authors: Braswell Ann Carol , Ebeling Mel , Wood Audria S. , White Taylor R. , Lausen Marissa A. , Isaac Sasha , Boggiano Mary Michelle 
Published: April 2021

Abstract
PurposeThe high global prevalence of obesity calls for the development of new weight loss strategies. Open-label placebo (OLP) has ameliorated symptoms of several medical and psychological conditions but has not been tested for obesity. With OLP, participants know they are receiving a placebo. This study investigated the effect of OLP pills to increase weight loss and reduce food craving.MethodsN=31 adults of diverse sex and ethnicity with a mean BMI of 35 underwent a simple eight-week long weight-loss intervention called Gut-Cued Eating. They were randomly assigned to take two pills daily for the entirety of the study (OLP group) or no pills (no-OLP group). All participants were weighed and completed baseline surveys. The OLP group also completed an original OLP survey which assessed compliance and perceived influence of putative mechanisms behind the efficacy of OLP on their change in weight. ResultsOLP did not augment weight loss or further reduce food craving following GCE. Controlling for demographics and baseline trait suggestibility did not affect the results. While the study was preliminary due to a small sample and limited statistical power, the results did not approach significance. Furthermore, the OLP survey indicated that belief in the effect of the pills was very low to none. OLP may prove beneficial in obesity if general belief in OLPs is increased and if it is delivered in a modality different from a pill given the likely negative associations between weight-loss pills and successful weight loss. Level of EvidenceLevel 1, experimental study
UARM Effective Route for Cu- and Zn- MOFs as Highly Efficient Adsorbents Towards Arsine (AsH3) Gas Adsorption: Design and a Systematic Study
Authors: Shahriari Taher , Kazemzadeh Parya , Zeraati Malihe , sargazi ghasem 
Published: April 2021

Abstract
Since it is essential to select the adsorbents, which are prepared with fast, environmentally friendly, and affordable methods, therefore, in this study, the Cu- and Zn- metal organic framework nanostructures were synthesized in the shortest route with the high efficiency by the effective method of ultrasonic assisted inverse micelle (UAIM) method. The synthesized samples were used as the new adsorbents in the arsine gas adsorption. The physicochemical properties of the products were examined in detail, so that the adsorbent dosage, temperature and pressure for the preparation of samples with distinctive characteristics were 0.05 mg, 25.00 °C, and 5.00 bar, respectively. Since the design and control of experimental parameters to find the best conditions for producing the samples with high adsorption efficiency is essential in this process, thus, for this purpose, fractional factorial design and response surface methodology were used. The results indicated the high efficiency of arsine gas adsorption for the synthesized samples in optimized conditions. The differences between arsine gas adsorption in this study in comparison with the previous studies could be due to the characteristic’s improvement using the effective synthetic methods as well as the systematic study of experimental parameters.
Unique Traditional Villages on the Loess Plateau of China: Historic Evolution and Challenges to Sustainable Development of Silo-Caves
Authors: Zhang Li , Lu Peng , Yan Lijie , Li Xiang , Yang Ruixia , Chen Panpan , Wang Xia 
Published: April 2021

Abstract
Silo-cave is a unique human habitation form on the Loess Plateau in northern China, which consists of an excavated 6–7 m deep pit as the courtyard and cave dwellings in the surrounding four walls. This architecture has had a history of more than 7000 years, and yet such "living fossils for the history of dwellings" are now facing great crises and challenges during rapid social and economic development. In this paper, remote sensing and GIS techniques are used to comprehensively and systematically investigate the spatial distributions and morphological characteristics of silo-caves at both the macro and micro scales. The research shows that silo-cave villages are mainly distributed in economically underdeveloped areas, such as West Henan (Yuxi), South Shanxi (Jinnan), Central Shaanxi (Guanzhong), and East Gansu (Longdong). The morphological evolution patterns of typical silo-cave villages are identified, including: (1) retaining the periphery and rebuilding the interior, (2) retaining the interior and expanding the periphery, and (3) expanding both the interior and periphery. These patterns are demonstrated to be influenced by many factors, including landforms, traffic conditions, economic development, population growth, and administrative division adjustment. Sustainable development of these traditional silo-cave villages relies on administrative policy and planning, people’s awareness of cultural heritage protection, culture inheritance, industrial transformation, and public services.
A bionic soft robotic glove mimicking finger actions based on sEMG recognition
Authors: Zhao Shumi , Wang Ziwen , Lei Yisong , Huang Shaotong , Zhang Jie , Liu Jianxun , Gong Zidan 
Published: April 2021

Abstract
Compared with rigid robots, soft robotics is more suitable to develop anthropomorphic digits that mimics the biological structures and dexterous motions of human finger. This study proposed a surface electromyogram (sEMG) sensors-based soft robotic glove system which was able to recognize the finger activities and execute the same operation via the bionic glove. Finger activities can be recognized by using electrodes sensors to monitor the electric potential variations on specific surface of the forearm muscle regions. A hybrid robotic digit was designed that utilizes pneumatic bellow actuators to satisfy the anatomical range of the finger motion in order to mimic finger action according to sEMG information. The moving trajectory of digit tip and the range motion of each joint of the robotic digit were measured in experiments under the pressure from 0kPa to 70kPa. The bionic soft robotic glove successfully demonstrated the finger action recognition and robotic digits controlling for a variety of manipulation tasks. The feasible results provided a novel technique for controlling the soft robotic glove through sEMG signals holistically and practically, and also give inspiration and guidance for multiple fingers remote operational applications.
Theoretical investigation on the influence of Seebeck and Thomson effects in a thermoelectric generator
Authors: Maduabuchi Chika Calistus , Gurevich Yuri G. 
Published: April 2021

Abstract
Four possible cases of modelling a thermoelectric generator (TEG) are presented in this paper. Case 1 models equal hot and cold junction Seebeck coefficient (SC) ignoring Thomson effect (TE), case 2 adopts equal hot and cold junction SC including TE, case 3 defines unequal hot and cold junction SC neglecting TE while case 4 represents unequal hot and cold junction SC with TE. The modified expressions for these cases are derived and employed in a comparative electric and geometric optimization of the TEG. The impact of the harmonious relationship between TE and SC on the optimum and maximum system performance parameters is studied and discussed. The results show that the systems performance can be enhanced or reduced depending on the operating temperature gradient and prevalent relationship between SC and TE. The results obtained from this work should be able to accurately predict the suitable TE and SC configuration for optimum and maximum system performance.
Globally Consistent Assessment of Coastal Eutrophication
Authors: Maúre Elígio , Terauchi Genki , Ishizaka Joji , Clinton Nicholas , DeWitt Michael 
Published: April 2021

Abstract
Eutrophication associated with increasing anthropogenic nutrient loading is an emerging global concern. Often, eutrophication is concomitant with negative impacts on ecosystems and human well-being. Nevertheless, the impacts and the extent of eutrophication are limited to regions with dedicated monitoring programmes. Here we introduce the Global Eutrophication Watch, the first global and interactive assessment map of coastal eutrophication potential (CEP). It is constructed on Google Earth Engine and it evaluates temporal trends in satellite chlorophyll-a (CHL), a proxy for phytoplankton biomass, to devise a global map of CEP. Our analyses suggest that, globally, coastal waters (depth ≤ 200 m) covering ~ 1.15 million km2 are eutrophic potential. We found that waters associated with CHL increasing trends—those with potential for further deterioration of water quality—are twofold higher than those showing signs of recovery. The tool effectively identified areas of known eutrophication with severe symptoms, such as dead zones, as well as those with limited to no information of the eutrophication. Our tool introduces the prospect for a consistent global assessment of eutrophication trends with major implications for monitoring Sustainable Development Goals (SDGs). This work contributes to the application of Earth Observations in support of SDGs.
Urban water dissipation calculation based on the improved water balance models
Authors: Zhou Ke 
Published: April 2021

Abstract
The urban water dissipation models are developed based on observation and different urban construction patterns. The regional water dissipation is selected in Zhengzhou, the capital city of Henan Province, China. According to model calculation results, the annual water dissipation was obtained (820.0 mm), which is significantly higher than that compared with the traditional methods (494. 4 mm). The results show that the water dissipation contribution rate of green space, inside building, hardened ground and pavement, and water surface are 40.58, 38.70, 18.32, and 2.40%, respectively. The water dissipation of hardened ground and pavement, green space, and water surface is greatly influenced by hydrological and meteorological factors. The water dissipation inside a building is proportional to the number of building layers and residents. The results show that water dissipation inside a building cannot be ignored and it is the main component of artificial water dissipation. Under the same rainfall conditions, the water dissipation of the hardened ground and pavement is inversely proportion to the runoff coefficient.
Evaluation of the Climate Forecast System Reanalysis data for hydrological model in the Arctic watershed Målselv
Authors: Bui Minh Tuan , Lu Jinmei , Nie Linmei 
Published: April 2021

Abstract
The high-resolution Climate Forecast System Reanalysis (CFSR) data have recently become an alternative input for hydrological models in data-sparse regions. However, the quality of CFSR data for running hydrological models in the Arctic is not well studied yet. This paper aims to compare the quality of CFSR data with ground-based data for hydrological modeling in an Arctic watershed, Målselv. The QSWAT model, a coupling of the hydrological model SWAT (soil and water assessment tool) and the QGIS, was applied in this study. The model ran from 1995 to 2012 with a 3-year warm-up period (1995–1997). Calibration (1998–2007), validation (2008–2012), and uncertainty analyses were performed by the Sequential Uncertainty Fitting Version 2 (SUFI-2) algorithm in the SWAT Calibration Uncertainties Program for each dataset at five hydro-gauging stations within the watershed. The objective function Nash–Sutcliffe coefficient of efficiency for calibration is 0.65–0.82 with CFSR data and 0.55–0.74 with ground-based data, which indicate higher performance of the high-resolution CFSR data than the existing scattered ground-based data. The CFSR weather grid points showed higher variation in precipitation than the ground-based weather stations across the whole watershed. The calculated average annual rainfall by CFSR data for the whole watershed is approximately 24% higher than that by ground-based data, which results in some higher water balance components. The CFSR data also demonstrates its high capacities to replicate the streamflow hydrograph, in terms of timing and magnitude of peak and low flow. Through examination of the uncertainty coefficients P-factors (≥0.7) and R-factors (≤1.5), this study concludes that CFSR data is a reliable source for running hydrological models in the Arctic watershed Målselv.
Психологические особенности адаптации психологов к онлайн-консультированию во время пандемии COVID-19
Authors: Скипор София И. , Воробьева Анастасия Е. 
Published: April 2021

Введение. Вынужденный переход консультирующих психологов на онлайн-консультирование потребовал от специалистов адаптации к новым условиям. Данных об адаптации российских практиков к онлайн-консультированию на фоне пандемии не обнаружено, информации об инновативности психологов недостаточно. Цель: выявить факторы адаптации психологов к интернет-консультированию в условиях пандемии. Основная гипотеза: выраженность инновативных качеств психолога связана с успешностью его адаптации к онлайн-консультированию во время пандемии COVID-19. Дополнительные: успешность адаптации психологов к онлайн-консультированию связана со стажем работы, регионом проживания, модальностью консультирования, положительным отношением к работе из дома. Новизна исследования: анализ факторов адаптации психологов к онлайн-консультированию на фоне пандемии COVID-19.
Методы. Выборка: 312 практикующих психологов из России. Для изучения адаптации и инновативных качеств применялись авторская анкета и «Методика исследования отношения личности к инновациям» (Н. М. Лебедева, А. Н. Татарко). Применены процедуры описательной статистики, критерии хи-квадрат и V Крамера.
Результаты. Психологи показали высокий уровень развития инновативных качеств и средний уровень готовности идти на риск ради успеха. Инновативные качества психолога связаны с успешностью адаптации к онлайн-консультированию. Связи между адаптацией и стажем работы, регионом проживания психолога обнаружено не было. Лучше всего к онлайн-формату адаптировались гештальт-терапевты, хуже – когнитивно-поведенческие психологи; предположение о связи модальности консультирования и адаптации подтвердилось. Положительное отношение к работе из дома в целом было связано с успешной адаптацией психологов. Нравилось работать из дома практикам, у которых не было проблемы с размытием границ «работа – дом».
Обсуждение результатов. Большинство психологов адаптировались к интернет-консультированию во время пандемии COVID-19, в том числе благодаря развитым инновативным качествам, возможностям для комфортной работы из дома, особенностям модальности, в которой они работают. Обсуждены ограничения работы. Даны рекомендации для будущих исследований.
Quantitative Proteomics Reveals SOS2-Related Proteins in Arabidopsis Under
Salt Stress
Authors: Yu Xiang , Zhao Xiaoyun , Yang Yongqing , Li Zhen 
Published: April 2021

Background:
Soil salinity is a major issue that seriously affects plant growth and cultivated
land utilization. Salt tolerance is one of the most fundamental biological processes that ensures
plant’s survival. SOS2 is one of the most important components of the Salt Overly Sensitive
(SOS) signaling pathway, which maintains plant ion homeostasis under salt stress. The SOS2-related
signaling pathways remain incompletely exploited especially at the proteomics level.

Objective:
In this paper, proteins potentially interacting with and regulated by SOS2 in Arabidopsis
were identified.

Methods:
The proteomes of Arabidopsis Wild Type (WT) and SOS2-deficient mutant (sos2-2) exposed
to 100 mM NaCl for 6 h were compared, proteins were identified using data-independent acquisition-
based quantitative proteomics strategy.

Results:
A total of 7470 proteins were identified and quantified, 372 Differentially Expressed Proteins
(DEP) were detected between WT and sos2-2 mutant under normal condition and 179 DEPs
were identified under salt treatment. Functional analysis showed that the DEPs were mainly involved
in protein binding and catalytic activity. Among the DEPs under salt stress, the protein expressions
of AVP1, Photosystem II reaction center protein A, B, C, and stress-responsive protein
(KIN2) were significantly up-regulated. LHCA1, LHCA2, LHCA4, ATPD and ATPE were significantly
down-regulated. These proteins were involved in biological processes including: stress response,
photosynthesis, transport and heat shock.

Conclusion:
These results revealed complexity of the functions of SOS2 in maintaining intracellular
homeostasis, in addition to its function in sodium homeostasis. Plant salt resistance is not independent
but closely related to metabolic processes including photosystem, ATP synthase, transport
and other stress resistances.
Lemongrass Extract Alleviates Oxidative Stress and Delayed the Loss of Climbing Ability in Transgenic Drosophila Model of Parkinson’s Disease
Authors: Siddique Yasir Hasan , Naz Falaq , Mantasha I. , Shahid M. 
Published: April 2021

Background:
Parkinson’s Disease (PD) is characterized by the aggregation of α-
synuclein, formation of Lewy bodies and the selective loss of dopaminergic neurons of mesencephalic
substantia nigra pars compacta (SNC) with the debilitating motor symptoms.

Introduction:
The available treatment for PD provides symptomatic relief with no control over the
progression of the disease. The treatment is also associated with several side effects. As neurodegeneration
in PD is also associated with oxidative stress, antioxidants from plants could play an
important role in reducing PD symptoms. With this aim, we decided to study the effect of Lemongrass
extract (LGE) on the transgenic Drosophila model of PD expressing human alpha synuclein
in the neurons.

Methods:
The PD flies were allowed to feed on different doses of LGE established in diet for 24
days and then assayed for climbing ability and oxidative stress markers. The molecular docking
study was also performed for citral (the component of the extract) and human α-synuclein.

Results and discussion:
A dose dependent significant improvement in the climbing ability and
reduction in oxidative stress was observed in the PD flies exposed to LGE. In our earlier study on
LGE, citral was found to be the main component of the extract by GC-MS analysis. The docking
results also support the positive interaction between citral and human α-synuclein.

Conclusion:
The results suggest that LGE is potent in reducing the PD symptoms being mimicked
in transgenic Drosophila.