bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life in advanced gastric/gastroesophageal junction cancer with second-line pembrolizumab in KEYNOTE-061
Authors: Van Cutsem Eric , Amonkar Mayur , Fuchs Charles S. , Alsina Maria , Özgüroğlu Mustafa , Bang Yung-Jue , Chung Hyun Cheol , Muro Kei , Goekkurt Eray , Benson Al B. , Sun Weijing , Wainberg Zev A. , Norquist Josephine M. , Chen Xinqun , Shih Chie-Schin , Shitara Kohei 
Published: August 2021

AbstractBackgroundIn the primary analysis population (i.e., PD-L1 combined positive score [CPS] ≥ 1) of the phase 3 KEYNOTE-061 study (NCT02370498), pembrolizumab did not significantly prolong overall survival or progression-free survival. Pembrolizumab had a favorable safety profile in the all-patient population. We present results of prespecified health-related quality of life (HRQoL) analyses.MethodsHRQoL was measured using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30), EORTC QLQ gastric cancer questionnaire (QLQ-STO22), and EuroQol 5-dimension, 3-level questionnaire (EQ-5D-3L). Data were analyzed from patients who received ≥ 1 dose of study treatment and who completed ≥ 1 HRQoL assessment. Key analyses included baseline to week 12 least-squares mean (LSM) change in global health status (GHS)/QoL, functional/symptom subscales, and time to deterioration (TTD; ≥ 10-point decrease from baseline) for specific subscales.ResultsThe HRQoL population included 371 patients (pembrolizumab,n = 188; paclitaxel,n = 183). Compliance and completion rates for all 3 questionnaires were similar in both groups at baseline and week 12. There was no difference in LSM change between groups (– 3.54; 95% CI – 8.92 to 1.84) in GHS/QoL at week 12. LSM change from baseline to week 12 for most QLQ-C30, QLQ-STO22, and EQ-5D-3L subscales indicated some worsening of QoL in both groups. TTD for GHS/QoL, nausea/vomiting, and appetite loss subscales in QLQ-C30 and the pain subscales in QLQ-STO22 were similar between treatment groups.ConclusionsIn this population with advanced gastric and GEJ cancer receiving second-line treatment, HRQoL was similar in patients receiving pembrolizumab and those receiving paclitaxel.Clinical trial registry and numberClinicalTrials.gov, NCT02370498.
Clinical epidemiological analysis of cohort studies investigating the pathogenesis of kidney disease
Authors: Tanaka Shigeru , Nakano Toshiaki , Tsuruya Kazuhiko , Kitazono Takanari 
Published: August 2021

AbstractIn recent years, large cohort studies of patients with chronic kidney disease (CKD) have been established all over the world. These studies have attempted to analyze the pathogenesis of CKD using a large body of published evidence. The design of cohort studies is characterized by the measurement of the exposure prior to the occurrence of the outcome, which has the advantage of clarifying the temporal relationship between predictors and outcomes and estimating the strength of the causal relationship between predictors and multiple outcomes. Recent advances in biostatistical analysis methods, such as propensity scores and risk prediction models, are facilitating causal inference using higher quality evidence with greater precision in observational studies. In this review, we will discuss clinical epidemiological research of kidney disease based on the analysis of observational cohort data sets, with a focus on our previous studies.
Risk management methodology in the supply chain: a case study applied
Authors: Hermoso-Orzáez M. J. , Garzón-Moreno J. 
Published: August 2021

AbstractThis work provides a general risk management procedure applied to synchronized supply chains. After conducting a literature review and taking the international standard ISO 28000 and ISO 31000 as a reference. The most important steps that enable organizations to carry out supply chain risk management are described. Steps such as defining the context, identifying and analyzing risks or avoiding them, controlling them and mitigating them are some of the main points of this work. On the other hand, we carried out a practical case in which the execution of this procedure is carried out in a real supply chain located in the city of Jaén. In this specific case study, the most important risks and those that require early treatment will be discussed. In addition, a series of suggestions and ideas will be established, by way of conclusions, that allow said organization to improve the results that we have obtained in risk management.
Biological invasion risk assessment of Tuta absoluta: mechanistic versus correlative methods
Authors: Ponti Luigi , Gutierrez Andrew Paul , de Campos Mateus Ribeiro , Desneux Nicolas , Biondi Antonio , Neteler Markus 
Published: August 2021

AbstractThe capacity to assess invasion risk from potential crop pests before invasion of new regions globally would be invaluable, but this requires the ability to predict accurately their potential geographic range and relative abundance in novel areas. This may be unachievable using de facto standard correlative methods as shown for the South American tomato pinworm Tuta absoluta, a serious insect pest of tomato native to South America. Its global invasive potential was not identified until after rapid invasion of Europe, followed by Africa and parts of Asia where it has become a major food security problem on solanaceous crops. Early prospective assessment of its potential range is possible using physiologically based demographic modeling that would have identified knowledge gaps in T. absoluta biology at low temperatures. Physiologically based demographic models (PBDMs) realistically capture the weather-driven biology in a mechanistic way allowing evaluation of invasive risk in novel areas and climes including climate change. PBDMs explain the biological bases for the geographic distribution, are generally applicable to species of any taxa, are not limited to terrestrial ecosystems, and hence can be extended to support ecological risk modeling in aquatic ecosystems. PBDMs address a lack of unified general methods for assessing and managing invasive species that has limited invasion biology from becoming a more predictive science.
Elastin-Derived Peptides in the Central Nervous System: Friend or Foe
Authors: Szychowski Konrad A. , Skóra Bartosz , Wójtowicz Anna K. 
Published: August 2021

AbstractElastin is one of the main structural matrix proteins of the arteries, lung, cartilage, elastic ligaments, brain vessels, and skin. These elastin fibers display incredible resilience and structural stability with long half-life. However, during some physiological and pathophysiological conditions, elastin is prone to proteolytic degradation and, due to the extremely low turnover rate, its degradation is practically an irreversible and irreparable phenomenon. As a result of elastin degradation, new peptides called elastin-derived peptides (EDPs) are formed. A growing body of evidence suggests that these peptides play an important role in the development of age-related vascular disease. They are also detected in the cerebrospinal fluid of healthy people, and their amount increases in patients after ischemic stroke. Recently, elastin-like polypeptides have been reported to induce overproduction of beta-amyloid in a model of Alzheimer's disease. Nevertheless, the role and mechanism of action of EDPs in the nervous system is largely unknown and limited to only a few studies. The article summarizes the current state of knowledge on the role of EDPs in the nervous system.
Nudging for Cleaner Air: Experimental Evidence from an RCT on Wood Stove Usage
Authors: Ruiz-Tagle J. Cristobal , Schueftan Alejandra 
Published: August 2021

AbstractAir pollution from wood burning is a serious problem in the developing world. In the cities of south-central Chile, households experience extremely high ambient air pollution levels due to massive combustion of wood as fuel for residential heating. To address this problem, in recent years new residential wood stoves—equipped with improved combustion technologies that are designed to be less-polluting—have replaced high-polluting ones. However, users’ behaviour in operating these improved stoves is a key factor that drives actual emissions. When users ‘choke the damper’ to extend the burning time of their wood fuel, it constrains the air flow in the wood stoves and creates a highly polluting combustion process. To address this issue, a behavioural intervention was designed to provide users with real-time feedback on their wood stoves’ air pollution emissions with the goal of ‘nudging’ them to use their stoves in a less polluting way. The intervention consists of an information sign that aligns with the wood stove’s damper lever and informs users about pollution emission levels according to the chosen setting of the wood stove’s damper. The information sign is complemented by the visit of a field assistant that explains the sign and provides an informational flyer (fridge magnet). To assess the effectiveness of this behavioural intervention a randomized controlled trial was conducted with selected households in the city of Valdivia, Chile. Results from this intervention show that households that were provided with the information sign reduced the frequency with which they used the most polluting settings of their stoves, inducing a behavioural change that results in a 10.8% reduction in residential pollution emissions.
Decision spaces in agricultural risk management: a mental model study of Austrian crop farmers
Authors: Hanger-Kopp Susanne , Palka Marlene 
Published: August 2021

AbstractDrought has become a dominant climate risk both around the world and in Europe, adding to the already challenging task of farming and governing the agricultural sector under climate change. Drought risk management is extremely complex. Apart from irrigation, most drought risk management options have more than one goal and may potentially have negative trade-offs with other risk management objectives. Moreover, government regulations and market mechanisms influence farmers’ decision-making. However, previous studies, both in developed and in developing countries, have predominantly focused on attitudinal and structural influencing factors on farmers’ risk management behavior. In this paper, we comprehensively investigate farmers’ decision spaces with respect to drought risk management. We address two applied research questions: (1) What are farmers’ preferred drought risk management measures? (2) From a farmer’s perspective, what are the dominant factors influencing drought risk management decisions? We find that farmers primarily think of production-based rather than financial measures with respect to drought risk management. At the same time, natural and technical constraints and enabling factors dominate their mental decision space, followed by public and private institutional aspects. This research provides a basis for the design of integrated and holistic drought risk management policy and the drought risk governance needed for sustainable use of land and water resources such as needed to address systemic risks and achieve the Sustainable Development Goals. Moreover, we introduce a novel approach using mental models extracted from interviews to explore cognitive representations of farmers' decision spaces. This approach has the potential to complement mainstream research using standardized surveys and behavioral models to analyze drivers of risk management.
Evaluation of spray pyrolysed In:ZnO nanostructures for CO gas sensing at low concentration
Authors: Ani Aninamol , Poornesh P. , Nagaraja K. K. , Hegde Gopalkrishna , Kolesnikov E. , Shchetinin Igor V. , Antony Albin , Kulkarni Suresh D. 
Published: August 2021

AbstractHerein, we report the role of indium (In) on the carbon monoxide sensing of ZnO thin films using a low-cost spray pyrolysis technique. The decrease in crystalline size was observed from XRD studies and hexagonal wurtzite structure was confirmed. Photoluminescence and XPS studies proved the presence of various defects in the films. The gas-sensing properties of films toward carbon monoxide (CO) gas indicate that 15 wt% of In in ZnO thin films (IZO) exhibit high response (1.84) to a low concentration of the gas (1 ppm) at 300 °C compared to undoped ZnO (0.53). The observed high response of 15 wt% IZO can be mainly endorsed to the oxygen vacancy defects as observed from the photoluminescence and XPS analysis. Further, the high response is complemented by high surface area and smaller grain size (~ 13.1 nm) with well-defined grain boundaries as evident from SEM analysis as well as XRD studies.
Negation Processing in Children with ADHD: The Generic Problem of Using Negation in Instructions
Authors: Dudschig Carolin , Kaup Barbara , Svaldi Jennifer , Gulewitsch Marco Daniel 
Published: August 2021

AbstractRecent studies have suggested that negation comprehension falls back onto inhibitory brain systems that are also crucial for impulse control and other non-linguistic control domains (Beltran et al., 2018, 2019; de Vega et al., 2016; Liu et al., 2020). Against this backdrop, the present pilot study investigated the use of negation within directional instructions (i.e., “not left”, “now left”, “not right”, “now right”) in children with ADHD and a control group. The results indicate that children in general have a long response delay following negative compared to affirmative instructions. Additionally, there was a tendency for this effect to be more pronounced in the ADHD group. Together, these results suggest that negation processing might indeed demand inhibitory control processes, which are differently available across different subgroups. Thus, the current study provides evidence that using negation in imperatives or instructions is generally rather critical and should be avoided if possible, but that negation use is probably even more problematic in specific clinical populations. Potential implications of these results will be discussed.
The New Vertical Merger Guidelines: Muddying the Waters
Authors: Salinger Michael A. 
Published: August 2021

AbstractThe new U.S. Department of Justice and Federal Trade Commission Vertical Merger Guidelines focus on how vertical mergers are likely to affect static pricing incentives. While vertical mergers can create incentives to increase prices, they can also provide incentives to decrease prices. Which of the possible outcomes is likely to occur depends on details that are generally difficult to measure. Potential competition between dominant firms, the theory of potential harm to competition that the 1984 Department of Justice Merger Guidelines stressed, remains a more compelling rationale for blocking vertical mergers than the likely effect on static pricing incentives.
Should pluralists be pluralists about pluralism?
Authors: Passmann Robert 
Published: August 2021

AbstractHow many correct logics are there? Monists endorse that there is one, pluralists argue for many, and nihilists claim that there are none. Reasoning about these views requires a logic. That is the meta-logic. It turns out that there are some meta-logical challenges specifically for the pluralists. I will argue that these depend on an implicitly assumed absoluteness of correct logic. Pluralists can solve the challenges by giving up on this absoluteness and instead adopt contextualism about correct logic. This contextualism is naturalistically appealing.
Analytical Solutions of Carbonate Acidizing in Radial Flow
Authors: Strongylis Polyneikis , Papamichos Euripides 
Published: August 2021

AbstractThe flow of reactive fluids into porous media, a phenomenon known as reactive infiltration, is important in natural and engineered systems. While most of the studies in this area cover theoretical and experimental analyses in linear acid flow, the present work concentrates on radial flow conditions from a wellbore in the field and on finding exact analytical solutions to moving boundary problems of the uniform dissolution front. Closed-form solutions are obtained for the transient convection–diffusion which allow the demarcation of the range of applicability of the quasi-static limit. The fluid velocity dependency of the diffusion–dispersion coefficient is also examined by comparing results from analytical solutions from constant and velocity-dependent coefficients. These contributions form the basis for linear stability analyses to describe acid fingering encountered in reservoir stimulation.
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model
Authors: Yin Hai-Yan , Fan Ya-Peng , Liu Juan , Li Dao-Tong , Guo Jing , Yu Shu-Guang 
Published: August 2021

AbstractPurinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be responsible for the local analgesic effect of moxibustion therapy, the predominant member in acupuncture family procedures also could trigger analgesic effect on pain diseases, it still remains unclear. In this study, we applied moxibustion to generate analgesic effect on complete Freund’s adjuvant (CFA)-induced inflammatory pain rats and detected the purine released from moxibustioned-acupoint by high-performance liquid chromatography (HPLC) approach. Intramuscular injection of ARL67156 into the acupoint Zusanli (ST36) to inhibit the breakdown of ATP showed the analgesic effect of moxibustion was increased while intramuscular injection of ATPase to speed up ATP hydrolysis caused a reduced moxibustion-induced analgesia. These data implied that purinergic ATP at the location of ST36 acupoint is a potentially beneficial factor for moxibustion-induced analgesia.
Geographic and Temporal Access to Basic Banking Services Offered through Post Offices in Wales
Authors: Sonea Andra , Westerholt René 
Published: August 2021

AbstractAccess to ‘universal banking services’ through the post office network has been a goal of the UK governments over the last twenty years. Various policies and mechanisms have been put in place in an attempt to maintain national geographical coverage with access points while increasing the financial viability of the network. One such mechanism is represented by the six official criteria for access to post offices, expressed as a percentage of the UK population living within one mile, three miles, and six miles of a post office. The method for calculating compliance with these access criteria is not published. Nor will any granular results be published, but only an annual statement that the criteria are being met. This article examines geographical and temporal access to post offices in order to understand the territorial coverage of the network and the impact this has on the provision of basic banking services. The area under investigation is Wales, for which we are reviewing the Government’s official access criteria. Through the Post Office Ltd website, we are collecting up-to-date information on the locations and opening hours of post offices in Wales. In addition, a detailed population grid is combined with calculated areas of equidistant geographical access, called isochrones, to determine the number of people who have access to the post office network. The isochrones are based on the Welsh road network and are calculated for different travel modes and thresholds using a powerful routing engine. Our results show that the official access criteria are largely unmet in Wales. In addition, and in contrast to previous studies, we show a rural-urban divide not in terms of spatial access, but in the combination of spatial and temporal access. The results are of both practical and theoretical value and will hopefully inform policy makers.
Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes
Authors: Yang Lin , Li Zhenmeiyu , Liu Guoping , Li Xiaosu , Yang Zhengang 
Published: August 2021

AbstractHuman cortical radial glial cells are primary neural stem cells that give rise to cortical glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) and olfactory bulb GABAergic interneurons. One of prominent features of the human cortex is enriched with glial cells, but there are major gaps in understanding how these glial cells are generated. Herein, by integrating analysis of published human cortical single-cell RNA-Seq datasets with our immunohistochemistical analyses, we show that around gestational week 18, EGFR-expressing human cortical truncated radial glial cells (tRGs) give rise to basal multipotent intermediate progenitors (bMIPCs) that express EGFR, ASCL1, OLIG2 and OLIG1. These bMIPCs undergo several rounds of mitosis and generate cortical oligodendrocytes, astrocytes and olfactory bulb interneurons. We also characterized molecular features of the cortical tRG. Integration of our findings suggests a general picture of the lineage progression of cortical radial glial cells, a fundamental process of the developing human cerebral cortex.
Active Inference as a Computational Framework for Consciousness
Authors: Vilas Martina G. , Auksztulewicz Ryszard , Melloni Lucia 
Published: August 2021

AbstractRecently, the mechanistic framework of active inference has been put forward as a principled foundation to develop an overarching theory of consciousness which would help address conceptual disparities in the field (Wiese 2018; Hohwy and Seth 2020). For that promise to bear out, we argue that current proposals resting on the active inference scheme need refinement to become a process theory of consciousness. One way of improving a theory in mechanistic terms is to use formalisms such as computational models that implement, attune and validate the conceptual notions put forward. Here, we examine how computational modelling approaches have been used to refine the theoretical proposals linking active inference and consciousness, with a focus on the extent and success to which they have been developed to accommodate different facets of consciousness and experimental paradigms, as well as how simulations and empirical data have been used to test and improve these computational models. While current attempts using this approach have shown promising results, we argue they remain preliminary in nature. To refine their predictive and structural validity, testing those models against empirical data is needed i.e., new and unobserved neural data. A remaining challenge for active inference to become a theory of consciousness is to generalize the model to accommodate the broad range of consciousness explananda; and in particular to account for the phenomenological aspects of experience. Notwithstanding these gaps, this approach has proven to be a valuable avenue for theory advancement and holds great potential for future research.
Inhomogeneity detection in the rainfall series for the Mae Klong River Basin, Thailand
Authors: Khalil Alamgir 
Published: August 2021

AbstractAn accurate and complete rainfall record is prerequisite for climate studies. The purpose of this research study was to evaluate the homogeneity of the rainfall series for the Mae Klong River Basin in Thailand. Monthly rainfall data of eight stations in the Mae Klong River Basin for the period 1971–2015 were used. The double mass curve analysis was used to check the consistency of rainfall data, whereas the absolute homogeneity was assessed using the Pettitt test, standard normal homogeneity test, Buishand test, and von Neumann test at a 5% significance level. The results of these tests were qualitatively classified as ‘useful’, ‘doubtful’, and ‘suspect’ according to the null hypothesis. Results of the monthly time series indicated the rainfall data as ‘useful’ for 75% of the stations, while two stations’ data were classified as ‘doubtful’ (Stn130221) and ‘suspect’ (Stn376401). On an annual scale, seven out of eight stations data were classified as ‘useful,’ while one station (Stn376401) data were classified as ‘suspect’. Double mass curve analysis technique was used for the adjustment of inhomogeneous data. The results of this study can help provide reliable rainfall data for climate studies in the basin.