bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metagenomic identification, purification and characterisation of the Bifidobacterium adolescentis BgaC β-galactosidase
Authors: Mulualem Daniel Mehabie , Agbavwe Christy , Ogilvie Lesley A. , Jones Brian V. , Kilcoyne Michelle , O’Byrne Conor , Boyd Aoife 
Published: January 2021

AbstractMembers of the human gut microbiota use glycoside hydrolase (GH) enzymes, such as β-galactosidases, to forage on host mucin glycans and dietary fibres. A human faecal metagenomic fosmid library was constructed and functionally screened to identify novel β-galactosidases. Out of the 16,000 clones screened, 30 β-galactosidase-positive clones were identified. The β-galactosidase gene found in the majority of the clones was BAD_1582 from Bifidobacterium adolescentis, subsequently named bgaC. This gene was cloned with a hexahistidine tag, expressed in Escherichia coli and His-tagged-BgaC was purified using Ni2+-NTA affinity chromatography and size filtration. The enzyme had optimal activity at pH 7.0 and 37 °C, with a wide range of pH (4–10) and temperature (0–40 °C) stability. It required a divalent metal ion co-factor; maximum activity was detected with Mg2+, while Cu2+ and Mn2+ were inhibitory. Kinetic parameters were determined using ortho-nitrophenyl-β-d-galactopyranoside (ONPG) and lactose substrates. BgaC had a Vmax of 107 μmol/min/mg and a Km of 2.5 mM for ONPG and a Vmax of 22 μmol/min/mg and a Km of 3.7 mM for lactose. It exhibited low product inhibition by galactose with a Ki of 116 mM and high tolerance for glucose (66% activity retained in presence of 700 mM glucose). In addition, BgaC possessed transglycosylation activity to produce galactooligosaccharides (GOS) from lactose, as determined by TLC and HPLC analysis. The enzymatic characteristics of B. adolescentis BgaC make it an ideal candidate for dairy industry applications and prebiotic manufacture.Key points• Bifidobacterium adolescentis BgaC β-galactosidase was selected from human faecal metagenome.• BgaC possesses sought-after properties for biotechnology, e.g. low product inhibition.• BgaC has transglycosylation activity producing prebiotic oligosaccharides.
Axiomatizations of the proportional division value
Authors: Zou Zhengxing , van den Brink René , Chun Youngsub , Funaki Yukihiko 
Published: January 2021

AbstractWe present axiomatic characterizations of the proportional division value for TU-games, which distributes the worth of the grand coalition in proportion to the stand-alone worths of the players. First, a new proportionality principle, called proportional-balanced treatment, is introduced by strengthening Shapley’s symmetry axiom, which states that if two players make the same contribution to any nonempty coalition, then they receive the amounts in proportion to their stand-alone worths. We characterize the family of values satisfying efficiency, weak linearity, and proportional-balanced treatment. We also show that this family is incompatible with the dummy player property. However, we show that the proportional division value is the unique value in this family that satisfies the dummifying player property. Second, we propose appropriate monotonicity axioms, and obtain axiomatizations of the proportional division value without both weak linearity and the dummifying player property. Third, from the perspective of a variable player set, we show that the proportional division value is the only one that satisfies proportional standardness and projection consistency. Finally, we provide a characterization of proportional standardness.
Injury epidemiology in men’s professional team sports: is media analysis helpful?
Authors: Szymski Dominik , Achenbach Leonard , Krutsch Volker , Alt Volker , Meffert Rainer , Krutsch Werner , Fehske Kai 
Published: January 2021

Abstract
Introduction
Epidemiological injury surveillance in professional sports is often based on online media analysis in order to collect necessary data. However, the validation of this study protocol is lacking. Therefore, this study aimed to identify the validity of injury surveillance in men’s professional team sports based on media reports.

Methods
In a retrospective cohort study, the validity of media-data-relating injuries was investigated in participating teams of the highest two German divisions in men’s professional basketball (BB) and handball (HB) in the season 2018/2019. Injury protocols completed by the team physicians were compared to those of sports media injury reports.

Results
The study population was composed of 133 athletes (54 BB and 79 HB). Of 343 injuries reported by the team physicians, 151 (44%) could be identified by means of sports media reports. Severe injuries (n = 75, 72%) were reported more likely in sports media compared to less severe injuries (n = 76, 32%, p < 0.00001). Odds ratio (OR) was 5.33 (95% CI 3.22–8.82). No differences regarding injury reporting could be seen between the two team sports.

Conclusion
For severe injuries, media analysis may be a sufficient method for data collection in popular men’s professional ball sports. An underestimation of true injury prevalence lies within the range of previous reported investigations concerning the validation of injury surveillance methods. Non-severe injuries could not be verified via media analysis in professional handball and basketball.
Real-time intraoperative functioning lumen imaging probe during endoscopic per-oral pyloromyotomy (pop)
Authors: Fathalizadeh Alisan , Klingler Michael , Landreneau Joshua , Allemang Matthew , Rodriguez John , Ponsky Jeffrey , El-Hayek Kevin 
Published: January 2021

Abstract
Background
Endoscopic per-oral pyloromyotomy (POP) has emerged as a safe and effective first line option in medically refractory gastroparesis. Determining the appropriate extent of the pyloromyotomy continues to present a challenge as there are no standardized tools for measuring changes in pyloric distensibility during the procedure. The objective of this study was to evaluate the utility of using impedance planimetry with endoscopic functional luminal imaging probe (FLIP) to measure changes in pyloric distensibility after POP, and to compare these changes with improvement in symptoms and objective gastric emptying.

Methods
Patients with medically refractory gastroparesis underwent POP with FLIP measurements of the pylorus (EndoFLIP®, Medtronic, Fridley MN). FLIP measurements, as well as changes in symptoms measured by the validated gastroparesis cardinal symptom index (GCSI) and scintigraphic gastric emptying studies (GES), were evaluated before and after POP.

Results
A total of 14 patients underwent measurement with FLIP during POP, 12 of whom had pre- and post-POP measurements. Mean pyloric diameter increased by 1.4 mm, from 13.9 mm to 15.3 mm (p = 0.0012). Mean distensibility index increased from 6.2 mm2/mmHg to 9.1 mm2/mmHg (p = 0.0074). Successful division of the pylorus was achieved in 100% of patients with a mean operative time of 36 min and no perioperative complications. The mean length of stay was 0.7 days (0–3 days). Post-POP mean GCSI score improved from 2.97 to 2.28 at a mean follow-up time of 27 days (p < 0.001). Objective improvement in gastric emptying was observed in 80% of patients with scintigraphic GES, with mean four-hour retention decreasing from 46.3% to 32.4% (p < 0.007).

Conclusions
FLIP is a safe and feasible tool to provide objective measurements during POP. Larger cohorts with longer follow-up are required to determine if measured improvements in pyloric diameter and distensibility are predictive of sustained improvements in GCSI and GES.
Reduction in anxiety and depression symptoms one year after knee replacement: a register-based cohort study of 403 patients
Authors: Mahdi Aamir , Hälleberg-Nyman Maria , Wretenberg Per 
Published: January 2021

Abstract
Background
Anxiety and depression are associated with patient dissatisfaction after total knee arthroplasty (TKA). Understanding whether preoperative knee-related symptoms could be a cause of anxiety and depression might help prevent unnecessary delay of surgery for this group of patients. We investigated changes in prevalence of anxiety and depression symptoms one year after TKA, and compared demographic data between patients with and without anxiety and depression symptoms preoperatively.

Methods
This was a prospective cohort study of 403 patients scheduled for TKA. Data on patient-related outcome measures and the prevalence of anxiety and depression symptoms were collected preoperatively and one year postoperatively. Before–after differences in anxiety/depression prevalence were compared with a chi-square test, and differences in demographic data between the groups with and without anxiety and/or depression symptoms were compared with an independent t test.

Results
Among the 15% of patients with anxiety symptoms before surgery, 59% had improved in these symptoms one year after surgery; while among the 10% with depression symptoms before surgery, 60% had improved one year after surgery. Patients with preoperative anxiety and/or depression were younger, and had higher body mass index, lower general quality of life (EQ-5D-3L), higher pain scores (visual analog scale), and lower knee-related (KOOS) scores on all subscales except sport.

Conclusion
Presurgical symptoms of anxiety and depression seem to be partly caused by knee symptoms. Understanding of this issue would offer better strategies to prevent unnecessary delay of surgery in this group of patients.
Association between urine pH and risk of contrast-associated acute kidney injury among patients after emergency percutaneous coronary intervention: a V-shape relationship?
Authors: Chen Hanchuan , He Chen , You Zhebin , Zhang Sicheng , He Haoming , Chen Xi′nan , Wang Sunying , Lin Kaiyang , Guo Yansong 
Published: January 2021

Abstract
Aim
We investigated whether perioperative urine pH was associated with contrast-associated acute kidney injury (CA-AKI) in patients undergoing emergency percutaneous coronary intervention (PCI).

Methods
The study enrolled 1109 consecutive patients undergoing emergency PCI. Patients were divided into three groups based on perioperative urine pH (5.0–6.0, 6.5– 7.0, 7.5–8.5). The primary endpoint was the development of CA-AKI, defined as an absolute increase ≥ 0.3 mg/dL or a relative increase ≥ 50% from baseline serum creatinine within 48 h after contrast medium exposure.

Results
Overall, 181 patients (16.3%) developed contrast-associated acute kidney injury. The incidences of CA-AKI in patients with urine pH 5.0–6.0, 6.5–7.0, and 7.5–8.5 were 19.7%, 9.8%, and 23.3%, respectively. After adjustment for potential confounding factors, perioperative urine pH 5.0–6.0 and 7.5–8.5 remained independently associated with CA-AKI [odds ratio (OR)1.86, 95% confidence interval (CI) 1.25–2.82, P = 0.003; OR 2.70, 95% CI 1.5–4.68, P < 0.001, respectively]. The association was consistent in subgroups of patients stratified by several CA-AKI risk predictors. However, the risk of CA-AKI associated with urine pH 7.5–8.5 was stronger in patients with worse renal function (estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2) (HR 5.587, 95% CI 1.178–30.599 vs. HR 2.487, 95% CI 1.331–4.579; overall interaction P < 0.05).

Conclusion
The urine pH and CA-AKI may underlie the V-shape relationship.
A Novel One- and Zero-Dimensional Model for Turbulent Jet Ignition
Authors: Bardis Konstantinos , Kyrtatos Panagiotis , Barro Christophe , Denisov Alexey , Wright Yuri Martin , Herrmann Kai , Boulouchos Konstantinos 
Published: January 2021

AbstractTurbulent jet ignition (TJI) is a promising combustion technology for burning highly diluted air-fuel mixtures. Computationally efficient models to assess the effect of the operating conditions and design parameters on the ignition propensity and timing are of paramount importance for the development of combustion systems employing TJI. To this end, a one-dimensional (1-D) jet model, which is based on the solution of the section integrated mass and momentum conservation equations, is derived in the present study. The model is extended with two additional transport equations for the turbulence intensity and the ignition precursor/tracer, that marks the ignition event. One-dimensional transient flamelet calculations are performed to generate tables for the ignition precursor source term that account for the turbulence and chemistry interaction. Further simplification of the model is carried out to obtain a novel penetration correlation and a computationally inexpensive Lagrangian ignition model. The extended jet model is hierarchically validated using available literature data for non-reactive and reactive jets, as well as experiments conducted in a state-of-the-art optically accessible prechamber. The derived model is able to reproduce both flow-related quantities (velocity and turbulence profiles, jet penetration) and the ignition delay time under different variations. This study also illustrates how numerical simulations in canonical configurations (one-dimensional flamelet) can be used in practical applications of TJI.
Biofilm-specific uptake of a 4-pyridone-based iron chelator by Pseudomonas aeruginosa
Authors: Houshmandyar Sharareh , Eggleston Ian M. , Bolhuis Albert 
Published: January 2021

AbstractIron is an essential nutrient for virtually all microbes and limiting the concentration of available iron is a potential strategy to be used as an alternative to antibiotic treatment. In this study we analysed the antimicrobial activity of two chelators, specifically 3-hydroxy-1,2-dimethyl-4(1H)-pyridone (deferiprone, DFP), which is clinically approved for the treatment of iron overload disorders, and its 1,2-diethyl homologue, CP94. Both compounds showed moderate activity towards planktonically growing P. aeruginosa cells, and the mechanism of action of these chelators was indeed by limiting the amount of free iron. Surprisingly, the compounds behaved very differently when the cells were grown in biofilms. DFP also showed inhibitory effects on biofilm formation but in contrast, CP94 stimulated this process, in particular at high concentrations. We hypothesised that CP94 behaves as an iron carrier, which was confirmed by our observation that it had antimicrobial synergy with the toxic metals, gallium and copper. This suggests that P. aeruginosa produces a biofilm-specific transport protein that recognises CP94 but not the closely related compound DFP.
A prospective observational study of patient-reported functioning and quality of life in advanced and metastatic breast cancer utilizing a novel mobile application
Authors: Richardson David , Zhan Lin , Mahtani Reshma , McRoy Lynn , Mitra Debanjali , Reynolds Maria , Odom Dawn , Hollis Kelly , Kaye James A. , Jones Cheryl , Hargis Jeffrey 
Published: January 2021

AbstractPurposeTo assess and describe patient-reported outcomes (PROs) in women with locally advanced/unresectable or metastatic breast cancer (aBC/mBC) with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR + /HER2 −) status receiving palbociclib combination therapy in a US real-world setting.MethodsA prospective, noninterventional, multicenter longitudinal study was conducted in US patients initiating treatment with palbociclib combination therapy for HR + /HER2 − aBC/mBC. PRO data (SF-12; CES-D-10; mood; pain; fatigue; interference of aBC/mBC or its treatment on family life, social life, physical activity, energy, and productivity; overall health rating; and quality of life [QOL]) were collected via a custom-developed mobile application at daily, weekly, and cycle-based intervals. Patient medical information (demographics, clinical characteristics, treatment information, and adverse events) was collected from medical records at baseline and at the end of the 6-month follow-up period.ResultsPatients’ general health status (SF-12) remained consistent throughout treatment and was generally consistent with published norms for individuals diagnosed with cancer. The presence of depression (CES-D-10) was low and did not change substantially over time. Mean pain and fatigue scores using an 11-point numeric rating scale were low and remained stable. Patients, on average, reported neutral or positive moods. Patient-reported QOL and overall health was primarily “Good,” “Very good,” or “Excellent.” Findings were consistent regardless of patient experience with neutropenia.ConclusionsPatients treated with palbociclib, on average, reported consistently low levels of pain and fatigue as well as good QOL and overall health that remained stable throughout the first 6 months of treatment regardless of episodes of neutropenia.
Milking It for All It’s Worth: Unpalatable Practices, Dairy Cows and Veterinary Work?
Authors: Clarke Caroline , Knights David 
Published: January 2021

AbstractViewing animals as a disposable resource is by no means novel, but does milking the cow for all its worth now represent a previously unimaginable level of exploitation? New technology has intensified milk production fourfold over the last 50 years, rendering the cow vulnerable to various and frequent clinical interventions deemed necessary to meet the demands for dairy products. A major question is whether or not the veterinary code of practice fits, or is in ethical tension, with the administration of ‘efficient’ techniques, such as artificial insemination, to enhance reproduction levels among cattle? Vets perform these interventions and their ‘success’ is measured by the maximisation of milk production, requiring perpetually pregnant cows. Our empirical research on 33 farm vets explores how their professional ethical code promising to protect the welfare of the animal ‘above all else’, is increasingly in conflict with, and subordinate to, the financial demands of clients. Since vets cannot stand outside of the productive power–knowledge relations that have intensified the consumption of animal bodily parts and secretions, we argue that a process of adiaphorization’ (Bauman and Lyon, Liquid surveillance, Polity Press, Cambridge, 2013, p. 8) occurs, whereby humans become morally indifferent to cruel practices deemed necessary to our consumerist ways of life. However, this indifference reflects and reinforces a taken-for-granted anthropocentrism among vets, animal owners and the population generally. We suggest that posthumanist ideas may offer new insights for the study of human–animal relations in organisations that transcend the coercive and negative impact of discourses that deny any alternative to prevailing farm/veterinary practices. Our study has major implications in relation to climate warming and zoonotic diseases, both partly derived from our unethical relationship to animals, that are increasingly threatening our, and their, lives.
Amplitude and rotational speed control of variable length pendulum by periodic input
Authors: Kajiwara Hidekazu , Aoyagi Manabu 
Published: January 2021

AbstractIn this paper, a control law to stabilize the amplitude or rotational speed of a variable length pendulum to a desired value by periodically changing the position of the center of gravity is proposed. First, the motion of the pendulum oscillating around a lower equilibrium point is analyzed using the averaging method, and a first-order differential equation for the amplitude of the pendulum is derived. Subsequently, using the derived equation of motion, a control law is designed to control the amplitude of the pendulum to the desired value. Similarly, the motion of a pendulum rotating continuously around the rotation axis is analyzed, the first-order differential equation for the angular velocity of the pendulum is derived, and then a control law of the rotational speed is designed. The derived nonlinear feedback control law consists of the amplitude, angle, and angular velocity of the pendulum in the case of amplitude control, and in the case of rotational speed control, the rotational velocity and angular acceleration of the pendulum. Finally, by using the proposed control method, it is shown that the amplitude and rotational speed of the pendulum can be controlled to the desired values.
Social image retrieval based on topic diversity
Authors: Wang Yaxiong , Zhu Li , Qian Xueming 
Published: January 2021

AbstractImage search re-ranking is one of the most important approaches to enhance the text-based image search results. Extensive efforts have been dedicated to improve the accuracy and diversity of tag-based image retrieval. However, how to make the top-ranked results relevant and diverse is still a challenging problem. In this paper, we propose a novel method to diversify the retrieval results by latent topic analysis. We first employNMF(Non-negative Matrix Factorization) Lee and Seung (Nature 401(6755):788–791, 1999) to estimate the initial relevance score to the queryq. Then, the initial relevance score is fed into an adaptive multi-feature fusion model to learn the final relevance score. Next, the diversification process is conducted. We group all the images by semantic clustering and estimate the topic distribution of each cluster by topic analysis. The clusters are ranked based on the topic distribution vector and the final retrieval image list is obtained by a greedy selection mechanism based on the estimated relevances. Experimental results on the NUS-Wide dataset show the effectiveness of the proposed approach.
Trope analysis and folk intuitions
Authors: Rennick Stephanie 
Published: January 2021

AbstractThis paper outlines a new method for identifying folk intuitions to complement armchair intuiting and experimental philosophy (X-Phi), and thereby enrich the philosopher’s toolkit. This new approach—trope analysis—depends not on what people report their intuitions to be but rather on what they have made and engaged with; I propose that tropes in fiction (‘you can’t change the past’, ‘a foreknown future isn’t free’ and so forth) reveal which theories, concepts and ideas we find intuitive, repeatedly anden masse.Imagination plays a dual role in both existing methods and this new approach: it enables us to create the scenarios that elicit our intuitions, and also to mentally represent them. The method I propose allows us to leverage the imagination of the many rather than the few on both counts—scenarios are both created and consumed by the folk themselves.
Measures of relative metacognitive accuracy are confounded with task performance in tasks that permit guessing
Authors: Vuorre Matti , Metcalfe Janet 
Published: January 2021

AbstractThis article investigates the concern that assessment of metacognitive resolution (or relative accuracy—often evaluated by gamma correlations or signal detection theoretic measures such asda) is vulnerable to an artifact due to guessing that differentially impacts low as compared to high performers on tasks that involve multiple-choice testing. Metacognitive resolution refers to people’s ability to tell, via confidence judgments, their correct answers apart from incorrect answers, and is theorized to be an important factor in learning. Resolution—the trial-by-trial association between response accuracy and confidence in that response’s accuracy—is a distinct ability from knowledge, or accuracy, and instead indicates a higher-order self-evaluation. It is therefore important that measures of resolution are independent of domain-knowledge accuracy. We conducted six experiments that revealed a positive correlation between metacognitive resolution and performance in multiple-choice mathematics testing. Monte Carlo simulations indicated, however, that resolution metrics are increasingly negatively biased with decreasing performance, because multiple-choice tasks permit correct guessing. We, therefore, argue that the observed positive correlations were probably attributable to an artifact rather than a true correlation between psychological abilities. A final experiment supported the guessing-related confound hypothesis: Resolution and performance were positively correlated in multiple-choice testing, but not in free-response testing. This study brings to light a previously underappreciated limitation in assessing metacognitive resolution and its relation to task performance in criterion tasks that may involve guessing.