bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
Authors: Kenfield Stacey A. , Van Blarigan Erin L. , Panchal Neil , Bang Alexander , Zhang Li , Graff Rebecca E. , Chen Yea‐Hung , Ryan Charles J. , Luke Anthony , Newton Robert U. , Tenggara Imelda , Schultz Brooke , Wang Elizabeth , Lavaki Emil , Zuniga Kyle , Pinto Nicole , Borno Hala , Aggarwal Rahul , Friedlander Terence , Koshkin Vadim S. , Harzstark Andrea , Small Eric , Chan June M. 
Published: October 2021

AbstractBackgroundExercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC).MethodsWe conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high‐ and moderate‐intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based on attendance, adherence, and tolerance; safety on adverse events; and acceptability on participant interviews.ResultsBetween March 2016 and March 2020, 25 patients were randomized (8 aerobic, 7 resistance, and 10 control). Twenty‐three men (82%) completed the 12‐week study. Men who completed the remote intervention attempted 90% and 96% of prescribed aerobic and resistance training sessions, respectively, and 86% and 88% of attempted sessions were completed as or more than prescribed. We observed changes in performance tests that corresponded with the exercise prescription. No safety concerns were identified. Ninety percent of participants interviewed were satisfied with the program and would recommend it to others.ConclusionsRemotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer.
Association between pregnancy intention and preconception health behaviors
Authors: Din Hena Naz , Strong David , Singh‐Carlson Savitri , Corliss Heather L. , Hartman Sheri J. , Madanat Hala , Su H. Irene 
Published: October 2021

BackgroundFemale adolescent and young adult (AYA) cancer survivors face higher infertility and pregnancy risks than peers with no cancer history. Preconception health behaviors such as physical activity (PA), tobacco smoking, and alcohol intake influence reproductive outcomes. In general populations, pregnancy intention is positively associated with healthy preconception behaviors, but it has not been studied among AYA survivors. The authors hypothesized that higher pregnancy intention would be associated with healthier behaviors, especially among AYA survivors with perceived infertility risk.MethodsA cross‐sectional analysis was conducted with data collected between 2013 and 2017 from 1071 female AYA survivors aged 18 to 39 years who had completed their primary cancer treatment and enrolled in an ovarian function study. Self‐reported intention dimensions were measured as a pregnancy intention score (PIS) and trying now to become pregnant. Multivariable linear (PA), binary (smoking), and ordinal (alcohol use) logistic regressions were used to estimate associations between intentions and preconception behaviors, with adjustments made for demographic and cancer characteristics. Effect modification by perceived infertility risk was assessed.ResultsThe mean PIS was 1.1 (SD, 0.77) on a 0 to 2 scale (2 = high intention), and 8.9% were attempting pregnancy now. A higher PIS was associated with increased PA (β, 0.08; 95% CI, 0.11‐1.04), whereas ambivalence in pregnancy intention was associated with lower alcohol consumption (odds ratio, 0.72; 95% CI, 0.55‐0.95). Pregnancy intentions were not associated with smoking. Perceived infertility risk strengthened the relationship between PIS and PA (P < .05).ConclusionsPregnancy intentions were associated with some healthier preconception behaviors in AYA survivors. Medical professionals caring for AYA survivors may consider pregnancy intention screening to guide conversations on preconception health.
SBM: A Smart Budget Manager in banking using machine learning, NLP, and NLU
Authors: Allegue Sahar , Abdellatif Takoua , El Abed Houssem 
Published: October 2021

SummaryNew business models underpinned by new standards of openness, flexibility, and agility are arising in the banking sector. Therefore, banks have to establish new strategies to keep and to extend their client base, especially with the explosive growth of customers' data and interaction touch‐points. Hence, banks and fintechs are in fierce competition to transform customers' data that incorporate their transactions into pertinent and significant knowledge for decision making. In this article, we present a novel system aimed toward solving a long‐standing and challenging issue: obtaining classifiers to automatically categorize bank transactions for a Smart Budget Manager. We fit and test our system using real data. The strength of our system lies in the novel combination of incremental machine learning algorithms with a natural language understanding for a fine‐grained categorization of bank transactions. Our system serves as a base layer for other advanced banking applications such as segmentation, next best offers and credit scoring. Our system is deployed in a real banking application of a Tunisian bank and has shown bank and customer's satisfaction.
A comprehensive experimental assessment of glyphosate ecological impacts in riparian forest restoration
Authors: Florido Flávia G. , Regitano Jussara B. , Andrade Pedro A. M. , Andreote Fernando D. , Brancalion Pedro H. S. 
Published: October 2021

AbstractCompetition with invasive grasses is one of the most important drivers of tree planting failures, especially in tropical forests. A widely disseminated weeding approach has been glyphosate spraying, the most used herbicide globally in forestry and ecosystem restoration. However, glyphosate use in restoration is highly controversial and requires further studies to elucidate its effects on restoration processes and the environment. We evaluated the use of glyphosate in riparian forest restoration and its impacts on tree planting costs, weed control efficiency, planted seedling performance, herbaceous and woody species regeneration, soil bacteria, and environmental contamination, using mowing treatments as a reference and based on a controlled experiment established in the Brazilian Atlantic Forest. Glyphosate spraying reduced by one‐half and one‐third the accumulated aboveground biomass of, respectively, weeds in general and of the invasive grassUrochloa decumbenscompared to mowing treatments, and it reduced the cost by half. The performance of planted tree seedlings was markedly favored by glyphosate spraying compared to mowing treatments, as expressed by improved seedling height (~twice higher), crown area (~5× higher), and basal area (~5× higher); the regeneration of both native woody and ruderal herbaceous plants were also enhanced. Neither glyphosate nor its metabolite Aminomethylphosphonic acid (AMPA) residues were detected in either water runoff or soil samples, but they were found at relatively high concentrations in the runoff sediments (from 1.32 to 24.75 mg/kg for glyphosate and from 1.75 to 76.13 mg/kg for AMPA). Soil bacteria communities differed before and after glyphosate spraying in comparison to mowing plots (without glyphosate). Glyphosate spraying was far more cost effective than mowing for controllingU. decumbensand greatly improved the performance of planted tree seedlings and natural regeneration, while not leaving residues in soil and water. However, the changes in the structure of bacterial communities and high concentration of glyphosate and AMPA residues in runoff sediments highlight the need for caution when using this herbicide in riparian buffers. We present alternatives for reducing glyphosate use and minimizing its risks in tree planting initiatives.
Modeling the evolution of herbicide resistance in weed species with a complex life cycle
Authors: Holmes K. Harrison , Lindquist John L. , Rebarber Richard , Werle Rodrigo , Yerka Melinda , Tenhumberg Brigitte 
Published: October 2021

AbstractA growing number of weed species have evolved resistance to herbicides in recent years, which causes an immense financial burden to farmers. An increasingly popular method of weed control is the adoption of crops that are resistant to specific herbicides, which allows farmers to apply the herbicide during the growing season without harming the crop. If such crops are planted in the presence of closely related weed species, it is possible that resistance genes could transfer from the crop species to feral populations of the wild species via gene flow and become stably introgressed under ongoing selective pressure by the herbicide. We use a density‐dependent matrix model to evaluate the effect of planting such crops on the evolution of herbicide resistance under a range of management scenarios. Our model expands on previous simulation studies by considering weed species with a more complex life cycle (perennial, rhizomatous weed species), studying the effect of environmental variation in herbicide effectiveness, and evaluating the role of common simplifying genetic assumptions on resistance evolution. Our model predictions are qualitatively similar to previous modeling studies using species with a simpler life cycle, which is, crop rotation in combination with rotation of herbicide site of action effectively controls weed populations and slows the evolution of herbicide resistance. We find that ignoring the effect of environmental variation can lead to an over‐ or under‐prediction of the speed of resistance evolution. The effect of environmental variation in herbicide effectiveness depends on the resistance allele frequency in the weed population at the beginning of the simulation. Finally, we find that degree of dominance and ploidy level have a much larger effect on the predicted speed of resistance evolution compared to the rate of gene flow.
Raspberry Pi nest cameras: An affordable tool for remote behavioral and conservation monitoring of bird nests
Authors: Hereward Hannah F. R. , Facey Richard J. , Sargent Alyssa J. , Roda Sara , Couldwell Matthew L. , Renshaw Emma L. , Shaw Katie H. , Devlin Jack J. , Long Sarah E. , Porter Ben J. , Henderson Jodie M. , Emmett Christa L. , Astbury Laura , Maggs Luke , Rands Sean A. , Thomas Robert J. 
Published: October 2021

Abstract

Bespoke (custom‐built) Raspberry Pi cameras are increasingly popular research tools in the fields of behavioral ecology and conservation, because of their comparative flexibility in programmable settings, ability to be paired with other sensors, and because they are typically cheaper than commercially built models.

Here, we describe a novel, Raspberry Pi‐based camera system that is fully portable and yet weatherproof—especially to humidity and salt spray. The camera was paired with a passive infrared sensor, to create a movement‐triggered camera capable of recording videos over a 24‐hr period. We describe an example deployment involving “retro‐fitting” these cameras into artificial nest boxes on Praia Islet, Azores archipelago, Portugal, to monitor the behaviors and interspecific interactions of two sympatric species of storm‐petrel (Monteiro's storm‐petrel Hydrobates monteiroi and Madeiran storm‐petrel Hydrobates castro) during their respective breeding seasons.

Of the 138 deployments, 70% of all deployments were deemed to be “Successful” (Successful was defined as continuous footage being recorded for more than one hour without an interruption), which equated to 87% of the individual 30‐s videos. The bespoke cameras proved to be easily portable between 54 different nests and reasonably weatherproof (~14% of deployments classed as “Partial” or “Failure” deployments were specifically due to the weather/humidity), and we make further trouble‐shooting suggestions to mitigate additional weather‐related failures.

Here, we have shown that this system is fully portable and capable of coping with salt spray and humidity, and consequently, the camera‐build methods and scripts could be applied easily to many different species that also utilize cavities, burrows, and artificial nests, and can potentially be adapted for other wildlife monitoring situations to provide novel insights into species‐specific daily cycles of behaviors and interspecies interactions.
Long‐term shifts in the functional diversity of abandoned wet meadows: Impacts of historical disturbance and successional pathways
Authors: Czortek Patryk , Borkowska Lidia , Lembicz Marlena 
Published: October 2021

AbstractInvestigating the direction of changes in functional diversity involving successional pathways and historical disturbances may be a promising tool for predictions of the effectiveness of the seminatural meadows conservation, with great emphasis on formulation of more cost‐effective restoration strategies. The goal of this research was to assess the differences in long‐term shifts in the functional diversity of plant species in seminatural wet meadows unmanaged for the last 40 years, under the influence of different successional pathways and historical disturbances. Using ordination techniques, linear mixed‐effect models, a set of plant functional traits and parameters of functional diversity, we assessed the importance of habitat filtering, competition, and niche partitioning in shaping community assembly changes over time. The most dramatic shifts in functional diversity were found in the Carex acutiformis successional pathway after topsoil removal, where colonization by successional inhibitors was the main driver causing decreases in functional dispersion and divergence. This was expressed as a decrease in the importance of habitat filtering and replacement of specialized species by competitors with heavier seeds and higher specific leaf area. Regarding the C. cespitosa and Salix cinerea pathways, the magnitudes of shifts in functional diversity were milder and differed less between the historical topsoil removal and mowing treatments, thereby maintaining a large role for niche partitioning in shaping the vegetation structure. The results of our study highlight the importance of tussock sedges and shrubs as effective buffers against the functional homogenization of meadows driven by the decreases in functional diversity of plant species, even from a long‐term perspective.
Plant pathogen‐mediated rapid acclimation of a host‐specialized aphid to a non‐host plant
Authors: Ali Farhan , Hu Xiaoyue , Wang Duoqi , Yang Fengying , Guo Hao , Wang Yongmo 
Published: October 2021

AbstractPolyphagous aphids often consist of host‐specialized lineages, which have greater fitness on their native hosts than on others. The underlying causes are important for understanding of the evolution of diet breadth and host shift of aphids. The cotton‐melon aphid Aphis gossypii Glover is extremely polyphagous with many strict host‐specialized lineages. Whether and how the lineage specialized on the primary host hibiscus shifts to the secondary host cucumber remains elusive. We found that the hibiscus‐specialized lineage suffered high mortality and gave birth to very few nymphs developing into yellow dwarfs on fresh cucumber leaves, and did not inflict any damage symptoms on cucumber plants. The poor performance did not improve with prolonged exposure to cucumber; however, it did significantly improve when the cucumber leaves were pre‐infected with a biotrophic phytopathogen Pseudoperonospora cubensis. More importantly, the hibiscus‐specialized lineage with two‐generation feeding experience on pre‐infected cucumber leaves performed as well as the cucumber‐specialized lineage did on fresh cucumber leaves, and inflicted typical damage symptoms on intact cucumber plants. Electrical penetration graph (EPG) indicated that the hibiscus‐specialized lineage did not ingest phloem sap from fresh cucumber leaves but succeeded in ingesting phloem sap from pre‐infected cucumber leaves, which explained the performance improvement of the hibiscus‐specialized lineage on pre‐infected cucumber leaves. This study revealed a new pathway for the hibiscus‐specialized lineage to quickly acclimate to cucumber under the assistance of the phytopathogen. We considered that the short feeding experience on pre‐infected cucumber may activate expression of effector genes that are related to specific host utilization. We suggest to identify host‐specific effectors by comparing proteomes or/and transcriptomes of the hibiscus‐specialized lineage before and after acclimating to cucumber.
Immunity in acute myeloid leukemia: Where the immune response and targeted therapy meet
Authors: Fink Avner , Hung Eric , Singh Indranil , Ben‐Neriah Yinon 
Published: October 2021

AbstractAcute myeloid leukemia (AML) is a highly aggressive disease with high relapse and mortality rates. Recent years have shown a surge in novel therapeutic development for AML, both in clinical and preclinical stages. These developments include targeted therapies based on AML‐specific molecular signatures as well as more general immune modulation and vaccination studies. In this review, we will explore the evolving arena of AML therapy and suggest some intriguing connections between immune system modulation and targeted therapy. Improved understanding of the immune system involvement in various stages of the disease and the crosstalk between immune effectors, targeted therapy, and AML cells can provide a better framework for designing the next generation of AML therapies.
Reconstruction of gully erosion based on exposed tree roots in a recent landform of Paricutin Volcano, Mexico
Authors: Franco‐Ramos Osvaldo , Ballesteros‐Cánovas Juan Antonio , Terrazas Teresa , Stoffel Markus , Vázquez‐Selem Lorenzo , Cerano‐Paredes Julian 
Published: October 2021

AbstractGullies in volcanic deposits are among the first signs of erosion that can be observed during or immediately after the volcanic activity and reflective of unstable conditions of newly formed deposits. Gully formation and erosion pulses may well continue to occur long after the initial landform was created, mostly as a result of torrential rainfall and/or land‐use changes. Yet, proper understanding of erosion dynamics and its relations with environmental drivers remains challenging as long‐term observations are, especially in volcanic terrain. Here we applied dendrogeomorphic approaches to (i) analyse both microscopic and macroscopic disturbances in tree roots exposed by gully erosion in a young volcanic landform of central Mexico and to (ii) quantify the evolution of erosion in the volcanic deposits of Paricutin Volcano. To this end we analysed 154 cross‐sections of 30 living, exposed roots of Pinus pseudoestrobus Lindl., of which 25 were used for anatomical and 129 for macroscopic analysis. Wood anatomical – or microscopic – disturbances were mostly in the form of strong growth reductions (~50%) in lumen area of earlywood tracheids, substantial increases in ring widths (mostly stemming from eccentric growth) and the increased formation of latewood cells. We observe major erosion pulses in 2010, 2012, 2015, 2016, 2017 and 2018, triggered primarily by torrential rainfall (with >100 mm 24 h−1 for the maximum intensity event: standard precipitation index values ≥ 2). Along the gully, the lower sector formed between 2009 and 2017, whereas the central sector exhibited important phases of exposure from 2012 to 2018. In the upper, most recent sector of the gully, erosion started only in 2017. Erosion rates in the lower and upper sectors are smaller with a channel widening rate of 6 to 16 cm yr−1. Around the main knickpoint found in the central part of the gully, retreat rates are up to 60 cm yr−1 and gully incision is 30 cm yr−1. The methods applied in this research are novel and can be applied to other volcanic environments with intense gully erosion, so as to provide baseline data for land‐use and environmental management plans.
A simulation study of carbon storage with active reservoir management
Authors: Dalkhaa Chantsalmaa , Jiang Tao , Burton‐Kelly Matthew E. , Scharenberg Mackenzie , Smith Valerie , Walker Jared L. , Duguid Andrew , Heinrichs Michael R. , Bosshart Nicholas W. , Sorensen James A. 
Published: October 2021

AbstractAs part of the Integrated Midcontinent Stacked Carbon Storage Hub (IMSCS‐Hub) project led by Battelle Memorial Institute, a study was conducted to determine the feasibility of storing carbon dioxide (CO2) in the stacked saline rock formations of the Sleepy Hollow Field (SHF), located in Red Willow County, southern Nebraska.A series of CO2 injection simulation scenarios, with and without active reservoir management (ARM; brine extraction), were evaluated to investigate the feasibility of storing 50+ million tonnes (Mt) of CO2. The results indicated CO2 injection combined with ARM may enable permanent storage of 50+ Mt of CO2.The area of review (AOR), the area in which underground sources of drinking water (USDWs) might be endangered during CO2 injection, was assessed for the simulation scenarios. In comparison to a case without ARM, brine extraction resulted in a much smaller AOR, covering an area of 42 square miles (108.8 km2), roughly one‐fourth the size of an AOR resulting from CO2 injection without ARM.The findings presented in this paper indicate that CO2 injection with ARM can improve the CO2 storage capacity of a geologic storage complex up to 100% while also reduce the rate of pressure buildup in the subsurface, resulting in a 75% reduction in AOR. This may help in lowering carbon capture and storage project costs, risks, and effort needed to meet monitoring requirements for a storage project. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd.