bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of system- and media-driven immersive capabilities on presence and affective experience
Authors: Standen Bradley , Anderson John , Sumich Alexander , Heym Nadja 
Published: October 2021

AbstractVirtual reality (VR) is receiving widespread attention as a delivery tool for exposure therapies. The advantage offered by VR over traditional technology is a greater sense of presence and immersion, which magnifies user effects and enhances the effectiveness of exposure-based interventions. The current study systematically examined the basic factors involved in generating presence in VR as compared to standard technology, namely (1) system-driven factors that are exclusive to VR devices while controlling general factors such as field of view and image quality; (2) media-driven factors of the virtual environment eliciting motivational salience through different levels of arousal and valence (relaxing, exciting and fear evoking stimuli); and (3) the effects of presence on magnifying affective response. Participants (N = 14) watched 3 different emotionally salient videos (1 × fear evoking, 1 × relaxing and 1 × exciting) in both viewing modes (VR and Projector). Subjective scores of user experience were collected as well as objective EEG markers of presence (frontal alpha power, theta/beta ratio). Subjective and objective presence was significantly greater in the VR condition. There was no difference in subjective or objective presence for stimulus type, suggesting presence is not moderated by arousal, but may be reliant on activation of motivational systems. Finally, presence did not magnify feelings of relaxation or excitement, but did significantly magnify users’ experience of fear when viewing fear evoking stimuli. This is in line with previous literature showing strong links between presence and generation of fear, which is vital in the efficacy of exposure therapies.
All-at-once multigrid approaches for one-dimensional space-fractional diffusion equations
Authors: Donatelli Marco , Krause Rolf , Mazza Mariarosa , Trotti Ken 
Published: October 2021

AbstractWe focus on a time-dependent one-dimensional space-fractional diffusion equation with constant diffusion coefficients. An all-at-once rephrasing of the discretized problem, obtained by considering the time as an additional dimension, yields a large block linear system and paves the way for parallelization. In particular, in case of uniform space–time meshes, the coefficient matrix shows a two-level Toeplitz structure, and such structure can be leveraged to build ad-hoc iterative solvers that aim at ensuring an overall computational cost independent of time. In this direction, we study the behavior of certain multigrid strategies with both semi- and full-coarsening that properly take into account the sources of anisotropy of the problem caused by the grid choice and the diffusion coefficients. The performances of the aforementioned multigrid methods reveal sensitive to the choice of the time discretization scheme. Many tests show that Crank–Nicolson prevents the multigrid to yield good convergence results, while second-order backward-difference scheme is shown to be unconditionally stable and that it allows good convergence under certain conditions on the grid and the diffusion coefficients. The effectiveness of our proposal is numerically confirmed in the case of variable coefficients too and a two-dimensional example is given.
Rural landscapes and agrarian spaces under soybean expansion dynamics: a case study of the Santarém region, Brazilian Amazonia
Authors: Coelho Andréa , Aguiar Ana , Toledo Peter , Araújo Roberto , do Canto Otávio , Folhes Ricardo , Adami Marcos 
Published: October 2021

AbstractFollowing the boom of soybean production from 2000 to 2006 in the Santarém region of the Brazilian Amazon, the mechanized agricultural area remained stable, unlike other regions. Deforestation was controlled, but this initial expansion led to the restructuring of the agrarian space in the region. Given this scenario, we aimed to understand the mechanized agricultural expansion effects in the region by comparing the periods 1999–2007 and 2007–2015. Our hypothesis was that it impacted heterogeneous actors and land tenure categories. We combined multi-temporal land change maps derived from remote sensing to land tenure information to evaluate how land change transitions differed over time, both in public (traditional and sustainable use official settlements) and private areas. In private areas, we observed a 12% reduction in forest cover in 1999–2007 and a 2.5% reduction in 2007–2015. In sustainable use settlements, forest loss was only 3% and 2% in each period, respectively. Mechanized agriculture occupied areas of family farming (42%), secondary vegetation (20%), pasture (20%), and forest areas (18%). Family farming lost most of the area to other uses. Within settlements, the area of family farming increased by 50% at the expense of the forest area. We conclude that the rise and fall of deforestation in the Brazilian Amazon hide multiple social and territorial processes. Understanding such dynamics is critical for establishing measures toward a sustainable future.
Syndrome of the trephined: clinical spectrum, risk factors, and impact of cranioplasty on neurologic recovery in a prospective cohort
Authors: Sveikata Lukas , Vasung Lana , El Rahal Amir , Bartoli Andrea , Bretzner Martin , Schaller Karl , Schnider Armin , Leemann Béatrice 
Published: October 2021

AbstractSyndrome of the trephined (SoT) is an underrecognized complication after decompressive craniectomy. We aimed to investigate SoT incidence, clinical spectrum, risk factors, and the impact of the cranioplasty on neurologic recovery. Patients undergoing a large craniectomy (> 80 cm2) and cranioplasty were prospectively evaluated using modified Rankin score (mRS), cognitive (attention/processing speed, executive function, language, visuospatial), motor (Motricity Index, Jamar dynamometer, postural score, gait assessment), and radiologic evaluation within four days before and after a cranioplasty. The primary outcome was SoT, diagnosed when a neurologic improvement was observed after the cranioplasty. The secondary outcome was a good neurologic outcome (mRS 0–3) 4 days and 90 days after the cranioplasty. Logistic regression models were used to evaluate the risk factors for SoT and the impact of cranioplasty timing on neurologic recovery. We enrolled 40 patients with a large craniectomy; 26 (65%) developed SoT and improved after the cranioplasty. Brain trauma, hemorrhagic lesions, and shifting of brain structures were associated with SoT. After cranioplasty, a shift towards a good outcome was observed within 4 days (p = 0.025) and persisted at 90 days (p = 0.005). Increasing delay to cranioplasty was associated with decreased odds of improvement when adjusting for age and baseline disability (odds ratio 0.96; 95% CI, 0.93–0.99, p = 0.012). In conclusion, SoT is frequent after craniectomy and interferes with neurologic recovery. High suspicion of SoT should be exercised in patients who fail to progress or have a previous trauma, hemorrhage, or shifting of brain structures. Performing the cranioplasty earlier was associated with improved and quantifiable neurologic recovery.
Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering
Authors: Karakaya Cansu , van Asten Jordy G. M. , Ristori Tommaso , Sahlgren Cecilia M. , Loerakker Sandra 
Published: October 2021

AbstractCardiovascular tissue engineering (CVTE) aims to create living tissues, with the ability to grow and remodel, as replacements for diseased blood vessels and heart valves. Despite promising results, the (long-term) functionality of these engineered tissues still needs improvement to reach broad clinical application. The functionality of native tissues is ensured by their specific mechanical properties directly arising from tissue organization. We therefore hypothesize that establishing a native-like tissue organization is vital to overcome the limitations of current CVTE approaches. To achieve this aim, a better understanding of the growth and remodeling (G&R) mechanisms of cardiovascular tissues is necessary. Cells are the main mediators of tissue G&R, and their behavior is strongly influenced by both mechanical stimuli and cell–cell signaling. An increasing number of signaling pathways has also been identified as mechanosensitive. As such, they may have a key underlying role in regulating the G&R of tissues in response to mechanical stimuli. A more detailed understanding of mechano-regulated cell–cell signaling may thus be crucial to advance CVTE, as it could inspire new methods to control tissue G&R and improve the organization and functionality of engineered tissues, thereby accelerating clinical translation. In this review, we discuss the organization and biomechanics of native cardiovascular tissues; recent CVTE studies emphasizing the obtained engineered tissue organization; and the interplay between mechanical stimuli, cell behavior, and cell–cell signaling. In addition, we review past contributions of computational models in understanding and predicting mechano-regulated tissue G&R and cell–cell signaling to highlight their potential role in future CVTE strategies.
Mal wieder ein neuer „Turn“ in der Gewaltforschung. Zu den Möglichkeiten und Grenzen eines prozesssoziologischen Zugangs zur Gewalt
Authors: Kühl Stefan 
Published: October 2021

ZusammenfassungDie Gewaltforschung ist inzwischen durch das immer kurztaktigere Ausrufen neuer „Turns“ gekennzeichnet. Merkmal dieser Turns ist, eine neue – bisher vermeintlich vernachlässigte – Perspektive in den Mittelpunkt der Forschung zu stellen. Der Beitrag beschäftigt sich mit einem neueren Turn, bei dem dafür plädiert wird, die Temporalität von Gewaltinteraktionen stärker in den Blick zu nehmen. Trotz einer auffällig starken Abgrenzungsrhetorik dieser prozesssoziologischen Sicht gegenüber interaktionssoziologischen Ansätzen handelt es sich – so das Argument des Artikels – lediglich um eine neue Spielart der dominierenden mikrosoziologischen Perspektive in der Gewaltforschung. Drei zentrale Probleme dieses prozesssoziologischen Ansatzes werden dargestellt: ein mikrosoziologisch verkürztes Verständnis von Prozessen, eine fehlende konzeptionelle Präzisierung von Faktoren jenseits der Zeitdimension sowie ein für Turns typisches Überziehen der eigenen Erklärungsansprüche. Mit einem – nicht ganz ernst gemeinten – Plädoyer für eine „systemsensible Gewaltforschung“ wird die Fruchtbarkeit der Ausrufung immer neuer Zentralperspektiven in der Gewaltforschung infrage gestellt.
Preliminary Assessment of Body Condition Score as a Possible Marker for the Targeted Selective Treatment of Dairy Sheep Against Gastrointestinal Nematodes
Authors: Tamponi Claudia , Dessì Giorgia , Varcasia Antonio , Knoll Stephane , Meloni Luisa , Scala Antonio 
Published: October 2021

Abstract
Purpose
In the fight against anthelmintic resistance, targeted selective treatments (TSTs), where only a small percentage of a flock receives treatment, have become increasingly popular. Overall, implementation of such treatments can be based on various parameters including Body condition score (BCS). As infection with non-bloodsucking nematodes, frequently encountered on sheep farms in the central Mediterranean basin, commonly causes bodyweight reduction, the aim of this research is to evaluate the effectiveness of BCS as a parameter for the implementation of TSTs in lactating dairy sheep with subclinical gastrointestinal nematode (GIN) infections from the island of Sardinia, Italy.

Methods
Faecal samples from 1012 ewes divided into 2 groups (third and fifth month of lactation) were collected and their BCS recorded. Faecal egg counts and coprocultures were performed for the assessment of the GIN burden and identification of present species.

Results
An overall GIN prevalence of 85.4% with a mean eggs per gram (EPG) of faeces of 210.1 ± 347.3 was found. Teladorsagia spp. and Trichostrongylus spp. were the GIN genera most identified. Overall, animals with the lowest BCS had the highest EPG values and a negative correlation (r = − 0.163) between the EPG values and BCS of the studied animals was found, which was most significant for older sheep.

Conclusion
This research confirmed BCSs and EPG values for GIN in sheep to be negatively correlated, particularly in older ewes. Application of TSTs for lactating sheep with a BCS < 2.25, especially to older ewes, could be beneficial in case of subclinical GIN infections, although further studies are needed to work out precise recommendation.
Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer’s Disease
Authors: Noor Aneeqa , Zafar Saima , Shafiq Mohsin , Younas Neelam , Siegert Anna , Mann Florian A. , Kruss Sebastian , Schmitz Matthias , Dihazi Hassan , Ferrer Isidre , Zerr Inga 
Published: October 2021

AbstractThe molecular determinants of atypical clinical variants of Alzheimer’s disease, including the recently discovered rapidly progressive Alzheimer’s disease (rpAD), are unknown to date. Fibrilization of the amyloid-β (Aβ) peptide is the most frequently studied candidate in this context. The Aβ peptide can exist as multiple proteoforms that vary in their post-translational processing, amyloidogenesis, and toxicity. The current study was designed to identify these variations in Alzheimer’s disease patients exhibiting classical (sAD) and rapid progression, with the primary aim of establishing if these variants may constitute strains that underlie the phenotypic variability of Alzheimer’s disease. We employed two-dimensional polyacrylamide gel electrophoresis and MALDI-ToF mass spectrometry to validate and identify the Aβ proteoforms extracted from targeted brain tissues. The biophysical analysis was conducted using RT-QuIC assay, confocal microscopy, and atomic force microscopy. Interactome analysis was performed by co-immunoprecipitation. We present a signature of 33 distinct pathophysiological proteoforms, including the commonly targeted Aβ40, Aβ42, Aβ4-42, Aβ11-42, and provide insight into their synthesis and quantities. Furthermore, we have validated the presence of highly hydrophobic Aβ seeds in rpAD brains that seeded reactions at a slower pace in comparison to typical Alzheimer’s disease. In vitro and in vivo analyses also verified variations in the molecular pathways modulated by brain-derived Aβ. These variations in the presence, synthesis, folding, and interactions of Aβ among sAD and rpAD brains constitute important points of intervention. Further validation of reported targets and mechanisms will aid in the diagnosis of and therapy for Alzheimer’s disease.
An Implicit Measure of Sexual Double Standard Endorsement in Emerging Adults: Reliability and Validity Aspects
Authors: van Lankveld Jacques J. D. M. , Emmerink Peggy M. J. , van den Eijnden Regina J. J. M. , ter Bogt Tom F. M. , Pat-El Ron J. , Vanwesenbeeck Ine 
Published: October 2021

AbstractPsychometric characteristics were investigated of an Implicit Association Test to assess implicit endorsement of the sexual double standard (SDS-IAT) in emerging adults. The reliability of the SDS-IAT was investigated focusing on internal consistency across different phases of the test. Convergent validity of the SDS-IAT was evaluated against the Scale for the Assessment of Sexual Standards in Youth, an explicit measure of SDS, and against gender investment. Divergent validity was evaluated against the personality characteristics of extraversion, neuroticism, and social desirability proneness. Gendered patterns were examined. Attenuation-corrected alphas demonstrated acceptable internal consistency, with alphas ranging for .65–.70. A modest level of explicit SDS endorsement was found in both female and male participants. In line with their explicit SDS level, a modest level of implicit SDS endorsement was found in male participants, whereas a reverse implicit SDS was found among young women. In agreement with our theoretical expectations, we found low convergent validity in multitrait-multimethod analysis of the SDS-IAT with a measure of explicit SDS endorsement, and with general level of investment in gender ideals. Similarly, divergent validity analysis revealed absence of significant correlations with the conceptually unrelated concepts of extraversion, neuroticism, and social desirability proneness, except for extraversion in female participants. The present findings suggest that implicit SDS endorsement can be assessed using the SDS-IAT. The finding that explicit and implicit SDS approvals differ in young female participants, while they align in young male participants, warrants further research.
A systematic literature review on the effects of mycotoxin exposure on insects and on mycotoxin accumulation and biotransformation
Authors: Niermans K. , Meyer A.M. , den Hil E.F. Hoek-van , van Loon J.J.A. , van der Fels-Klerx H.J. 
Published: October 2021

AbstractNovel protein sources for animal feed are needed, and the use of insects as feed ingredient is explored. The insect production sector offers opportunities for a circular and sustainable approach to feed production by upgrading waste or side streams into high-quality proteins. However, potential food or feed safety issues should be studied in advance. Mycotoxins, such as aflatoxin B1, are natural contaminants commonly found in agricultural crops and have proven to be detrimental to the agricultural industry, livestock, and human health. This systematic review aims to provide a comprehensive overview of the published evidence on effects of mycotoxin exposure on insect growth and survival, mycotoxin accumulation within the insect body, and metabolization of various mycotoxins by insects. The review includes 54 scientific articles published in the past 55 years, in total covering 32 insect species. The main findings are the following: (1) Insects of the order Coleoptera show lower mortality after exposure to aflatoxin B1 when compared to Lepidoptera and Diptera; (2) effects of mycotoxins on larval growth and survival are less detrimental in later larval stages; (3) accumulation of mycotoxins was low in most insect species; (4) mycotoxins are metabolized within the insect body, the degree of which depends on the particular mycotoxin and insect species; (5) cytochrome P450s are the main family of enzymes involved in biotransformation of mycotoxins in some insect species. Results of this review support an optimistic outlook for the use of mycotoxin-contaminated waste streams as substrate for insect rearing.
Using Climate Factors to Estimate Flood Economic Loss Risk
Authors: Hu Xinjia , Wang Ming , Liu Kai , Gong Daoyi , Kantz Holger 
Published: October 2021

AbstractEstimation of economic loss is essential for stakeholders to manage flood risk. Most flooding events are closely related to extreme precipitation, which is influenced by large-scale climate factors. Considering the lagged influence of climate factors, we developed a flood-risk assessment framework and used Hunan Province in China as an example to illustrate the risk assessment process. The main patterns of precipitation—as a connection between climate factors and flood economic losses—were extracted by the empirical orthogonal function (EOF) analysis. We identified the correlative climate factors through cross-correlation analysis and established a multiple stepwise linear regression model to forecast future precipitation patterns. Risk assessment was done based on the main precipitation patterns. Because the economic dataset is limited, a Monte Carlo simulation was applied to simulate 1000-year flood loss events under each precipitation regime (rainy, dry, normal years) to obtain aggregate exceedance probability (AEP) and occurrence exceedance probability (OEP) curves. We found that precipitation has a strong influence on economic loss risk, with the highest risk in rainy years. Regional economic development imbalances are the potential reason for the varying economic loss risks in different regions of Hunan Province. As the climate indices with at least several months prediction lead time are strong indicators in predicting precipitation, the framework we developed can estimate economic loss risk several months in advance.
Prevalence and psychiatric comorbidities of night-eating behavior in obese bariatric patients: preliminary evidence for a connection between night-eating and bipolar spectrum disorders
Authors: Brancati Giulio Emilio , Barbuti Margherita , Calderone Alba , Fierabracci Paola , Salvetti Guido , Weiss Francesco , Santini Ferruccio , Perugi Giulio 
Published: October 2021

Abstract
Purpose
The co-occurrence of obesity, eating and mood disorders has been frequently reported in clinical and epidemiological settings. This study aimed to explore the prevalence of night-eating obese patients referred for bariatric surgery and to identify associated psychopathology and psychiatric comorbidity.

Methods
The sample was composed of 121 obese patients consecutively enrolled between November 2010 and May 2012 during psychiatric evaluations for bariatric intervention. Clinical features and psychiatric diagnoses were collected. Night-eating was investigated through the administration of the Night-eating Questionnaires (NEQ) and was defined as the presence of self-reported evening hyperphagia and/or nocturnal ingestions. Binge-eating and purging behaviors and general psychopathology were respectively assessed using the Bulimic Investigatory Test, Edinburgh and the Symptom Checklist-90-Revised.

Results
Night-eating was reported by twenty subjects (16.5%). Patients with night-eating behavior were significantly more frequently diagnosed with bipolar spectrum disorders and with comorbid eating and mood disorders in comparison with other patients. Night-eating patients showed significantly more binging/purging behaviors and greater severity of somatization, obsessive–compulsive symptoms, phobic anxiety, psychoticism and sleep disorders. Patients with bipolar disorder type 1 or 2 scored significantly higher than those without mood disorders at NEQ total score, mood/sleep and nocturnal ingestions subscales, but also scored significantly higher than other patients with mood disorders at the latter subscale.

Conclusion
Patients with evening hyperphagia and/or nocturnal ingestions should be carefully evaluated to detect possible bipolar spectrum disorders and other eating disorders. Prompt management of these conditions should be provided before bariatric interventions.

Level of evidence
V, cross-sectional descriptive study.
Sensing Stemness
Authors: Bowman Teresa V. , Trompouki Eirini 
Published: October 2021

Abstract

Purpose of Review

Hematopoietic stem cells (HSCs) are formed embryonically during a dynamic developmental process and later reside in adult hematopoietic organs in a quiescent state. In response to their changing environment, HSCs have evolved diverse mechanisms to cope with intrinsic and extrinsic challenges. This review intends to discuss how HSCs and other stem cells co-opted DNA and RNA innate immune pathways to fine-tune developmental processes.

Recent Findings

Innate immune receptors for nucleic acids like the RIG-I-like family receptors and members of DNA sensing pathways are expressed in HSCs and other stem cells. Even though the “classic” role of these receptors is recognition of foreign DNA or RNA from pathogens, it was recently shown that cellular transposable element (TE) RNA or R-loops activate such receptors, serving as endogenous triggers of inflammatory signaling that can shape HSC formation during development and regeneration.

Summary

Endogenous TEs and R-loops activate RNA and DNA sensors, which trigger distinct inflammatory signals to fine-tune stem cell decisions. This phenomenon could have broad implications for diverse somatic stem cells, for a variety of diseases and during aging.