bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53
Authors: Kabir Md , Hu Xiaoping , Martin Tiphaine C. , Pokushalov Dmitry , Kim Yong Joon , Chen Yiyang , Zhong Yue , Wu Qiong , Chipuk Jerry E. , Shi Yi , Xiong Yan , Gu Wei , Parsons Ramon E. , Jin Jian 
Published: December 2024

AbstractPharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Acetylation Targeting Chimera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate the p53Y220C mutant. However, p300/CBP are the only acetyltransferases harnessed for AceTAC development to date. In this study, it is demonstrated for the first time that the TAF1 acetyltransferase can be recruited to acetylate p53Y220C. A novel TAF1‐recruiting AceTAC, MS172 is discovered, which effectively acetylates p53Y220C lysine 382 in a concentration‐, time‐ and TAF1‐dependent manner via inducing the ternary complex formation between p53Y220C and TAF1. Notably, MS172 suppresses the proliferation in multiple p53Y220C‐harboring cancer cell lines more potently than the previously reported p300/CBP‐recruiting p53Y220C AceTAC MS78 with little toxicity in p53 WT and normal cells. Additionally, MS172 is bioavailable in mice and suitable for in vivo efficacy studies. Lastly, novel upregulation of metallothionine proteins by MS172‐induced p53Y220C acetylation is discovered using RNA‐seq and RT‐qPCR studies. This work demonstrates that TAF1 can be harnessed for AceTAC development and expands the very limited repertoire of the acetyltransferases that can be leveraged for developing AceTACs, thus advancing the targeted protein acetylation field.
Novel Phosphazenium Tetrafluoroborate Dopant Enables Efficient and Thermally Stable n‐Doped Organic Semiconductors
Authors: Wei Huan , Guo Jing , Liu Heng , Wu Tong , Chen Ping‐An , Dong Chuanding , Wang Shu‐Jen , Schumacher Stefan , Bai Yugang , Lei Ting , Wang Suhao , Hu Yuanyuan 
Published: December 2024

AbstractThermal stability is crucial for doped organic semiconductors (OSCs) and their applications in organic thermoelectric (OTE) devices. However, the capacity of n‐dopants to produce thermally stable n‐doped OSC films has not been thoroughly explored, with few reports of high thermal stability. Here, a novel n‐dopant, phosphazenium tetrafluoroborate (P2BF4) is introduced, which effectively induces n‐doping in N2200, P(PzDPP‐CT2) and several other commonly used OSCs. Remarkably, the electrical conductivity of P2BF4‐doped OSC films remains almost unchanged even after heating at temperatures > 150 °C for 24 h, far superior to the films doped with benchmark N‐DMBI. The exceptional thermal stability observed in P2BF4‐doped P(PzDPP‐CT2) films allows for stable operation of the corresponding organic thermoelectric devices at 150 °C for 16 h, a milestone not previously achieved. This study offers valuable insights into the development of n‐dopants capable of producing OSCs with outstanding thermal stability, paving the way for the practical realization of OTE devices with enhanced operation stability.
Flocculating‐Regulated TiO2 Deposition Enables the Synergistic Effect of Doping for Perovskite Solar Cells with Efficiency Exceeding 25.8%
Authors: Yan Huilin , Zhao Xing , Huang Hao , Wu Danxia , Zhu Pengkun , Li Danni , Fan Bingbing , Qiu Yujie , Yang Yuqing , Geng Qi , Cui Peng , Yang Yingying , Lan Zhineng , Li Meicheng 
Published: December 2024

AbstractThe planar perovskite solar cells (PSCs) using TiO2 as the electron transport layer (ETL) are undergoing a stagnated efficiency improvement, which the inferior TiO2 ETL mainly limits. Herein, a flocculating‐regulated TiO2 deposition using SnCl2·2H2O is reported as the flocculate to control the nanoparticle size finely for optimizing TiO2 deposition and to achieve a synergistic Sn doping. The SnCl2·2H2O incorporated into bath precursor can bridge‐link the suspended nanoparticles, which promotes the precipitation of large‐sized nanoparticles and leaves the smaller‐sized nanoparticles for deposition, leading to a compact TiO2 film with marked reduced surface roughness. Meanwhile, along with flocculating‐regulated TiO2 deposition, it can also be achieved the Sn‐doping of TiO2, which increases the conductivity of TiO2 thin films by ≈2.5 times. As a consequence, attributing to the optimized interface contact and accelerated interfacial electron transport, the planar PSCs achieved a certification efficiency of 25.85%, the highest value among the TiO2‐based planar PSCs to date. In addition, the PSCs can maintain 99% of their initial efficiency after more than 4500 h of storage in ambient air, showing excellent stability.
Controlling Grain Boundary Segregation to Tune the Conductivity of Ceramic Proton Conductors
Authors: Kindelmann Moritz , Povstugar Ivan , Kuffer Severin , Jennings Dylan , Ebert Julian N. , Weber Moritz L. , Zahler M. Pascal , Escolastico Sonia , Almar Laura , Serra Jose M. , Kaghazchi Payam , Bram Martin , Rheinheimer Wolfgang , Mayer Joachim , Guillon Olivier 
Published: December 2024

AbstractAcceptor‐doped barium zirconates are of major interest as proton‐conducting ceramics for electrochemical applications at intermediate operating temperatures. However, the proton transport through polycrystalline microstructures is hindered by the presence of a positive space charge potential at grain boundaries. During high‐temperature sintering, the positive charge acts as a driving force for acceptor dopant segregation to the grain boundary. Acceptor segregation to grain boundaries has been observed in sintered ceramics, but the fundamental relationship between the segregation kinetics and the protonic conductivity is poorly understood. Here, a comprehensive study of the influence of acceptor dopant segregation on the electrochemical properties of grain boundaries in barium zirconate ceramics is presented. An out‐of‐equilibrium model material that displays no detectable Y segregation at its grain boundaries is explicitly designed. This model material serves as a starting point to measure the kinetics of segregation and the induced changes in grain boundary conductivity upon varying thermal histories. Furthermore, the electrochemical results from impedance spectroscopy to atomic resolution transmission electron microscopy, atom probe tomography, and DFT simulations are correlated. It is discovered that acceptor dopant segregation drastically increases the proton conductivity in both the model system and several other application‐relevant compositions.
Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single‐center observational cohort study
Authors: Yu Yanna , Li Fen , Wang Zhan , Ni Zhibin , Zhang Shu , Zhao Weihong , Pei Xiaohua 
Published: December 2024

AbstractObjectivesComorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients.MethodologyThe MHD patients in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were taken as the subjects. Claims‐based disease‐specific refinements matching translation to ICD‐10 and flexibility (CDMF‐CCI) model and Liu model were selected as the candidate models for this verification research. Univariate and multivariate Cox regression calculations were used to analyze the independent predictive effect of the models on survival rate.ResultsAnnually, nearly 500 patients undergo hemodialysis treatment. From January 2019 to June 2022, a total of 199 patients succumbed, with a mean age of 65.2 years. During these 4 years, the mortality rates were 13.04%, 9.68%, 11.69%, and 6.39%, respectively. The leading causes of death were sudden demise (82 patients, 41.2%), cardiovascular disease (48 patients, 24.1%), pulmonary infection (33 patients, 16.5%), and stroke (19 patients, 9.5%). When compared to individual indices, the CDMF‐CCI model displayed more accurate and predictive results, with an HR of 1.190 (P = 0.037). Conversely, the Liu model failed to identify high‐risk individuals.ConclusionThe MHD patients face a significant risk of mortality. When compared to univariate parameters and the Liu model, the CDMF‐CCI model exhibits superior predictive accuracy for mortality in MHD patients.
Impacts of COVID‐19 pandemic on short‐term outcomes of low anterior resection performed in hospitals with different surgical volumes
Authors: Maeda Hiromichi , Endo Hideki , Seishima Ryo , Hibi Taizo , Takeuchi Masashi , Takemura Yusuke , Yamamoto Hiroyuki , Taketomi Akinobu , Kakeji Yoshihiro , Seto Yasuyuki , Ueno Hideki , Mori Masaki , Shirabe Ken , Kitagawa Yuko 
Published: December 2024

AbstractAimTo evaluate the impact of the coronavirus disease (COVID‐19) pandemic on short‐term outcomes of low anterior resection (LAR) across hospitals classified by surgical volume.MethodsData of patients who underwent elective LAR for rectal cancer between 2018 and 2022 were obtained from the National Clinical Database of Japan. Hospitals were categorized into high‐, medium‐, and low‐volume groups. Each group was constituted to represent approximately one‐third of all surgeries performed between 2018 and 2019. The standardized morbidity/mortality ratios (SMRs) of Clavien–Dindo grade ≥3 (CD ≥ 3) complications were the primary endpoint. The secondary endpoints included anastomotic leakage, pneumonia, and surgical mortality.ResultsThis study analyzed 91 800 cases of elective LAR, with 10.5% experiencing CD ≥ 3 complications, 8.8% anastomotic leakage, 0.9% pneumonia, and 0.5% surgical mortality. Despite COVID‐19, SMRs of CD ≥ 3 complications decreased from 2018 to 2022 across all groups. However, increases in the rates and SMRs of CD ≥ 3 complications were observed in low‐volume hospitals around mid‐2020, followed by a decline. Anastomotic leakage showed similar trends. The rates and SMRs of pneumonia and surgical mortality remained unchanged. Notably, anastomotic leakage rates were 7.6%, 8.9%, and 10.0% in high‐, medium‐, and low‐volume hospitals, respectively, indicating superior outcomes in high‐volume hospitals.ConclusionEarly COVID‐19 waves may have disproportionately affected low‐volume hospitals. However, the decline in SMRs of CD ≥ 3 complications from 2018 to 2022 across all three groups suggests the robustness and resilience of surgical services for rectal cancer in Japan. The potential disparity in short‐term outcomes among hospitals is a new concern.
Sexual Signaling and Sociosexual Behaviors in Relation to Rank, Parasites, Hormones, and Age in Male Vervet Monkeys (Chlorocebus pygerythrus) in Uganda
Authors: Snyder Karin P. , Greenberg Dina , Fane Taylor , Filazzola Alessandro , Mastromonaco Gabriela F. , Schoof Valérie A. M. 
Published: December 2024

ABSTRACTSecondary sexual characteristics, and the extent to which they are expressed, can convey information about the signaller. The blue scrotum and red penis of male vervet monkeys (Chlorocebus pygerythrus) make them a good species in which to examine inter‐ and intramale variation in signal expression. We quantified genital hue and luminance of male vervets at Lake Nabugabo, Uganda from standardized photos of male genitalia taken in May to June 2016, January to March 2019, and April to June 2019 to examine how dominance rank, fecal androgens (fARMs), fecal glucocorticoids (fGCMs), and parasitism related to achromatic (i.e., luminance) and chromatic (i.e., hue) aspects of scrotal and penile coloration, as well as how genital color related to sociosexual behaviors. We examined 182 photoshoots, 214 fecal samples for hormone analyses, and 152 for parasite analyses. Linear models indicate that genital color is linked to male dominance rank; high‐ranking males had a more luminant (i.e., brighter) scrotum and a redder penis. Within males, color characteristics remained relatively stable over the short‐term and changed moderately over the long‐term. The direction of change was inconsistent for all color characteristics except scrotal luminance, which increased in all males over the long‐term. Males with a darker penis received more mating presentations, while higher‐ranking males received more mating refusals than low‐ranking males, suggesting that females pay attention to penile color. We did not find support for any parasite or hormone mediation of color, and while there was a correlation between fGCM and fARMs, this was positive rather than negative as predicted by the stress‐linked immunocompetence handicap hypothesis. Overall, our results indicate that the production of genital color may serve as an intra‐ and/or intersexual signal of male dominance rank and age in vervets.
Engineering the Self‐Assembly Pathways of POSS‐Peptide Amphiphiles to Form Diverse Cross‐β Structures
Authors: Du Zhen , Dai Junhao , Wang Zhibo , Ye Zushan , Lei Huanyu , Guo Qing‐Yun , Yan Xiao‐Yun , Li Mu , Li Minzhao , Zhao Wangshen , Zhang Beijing , Huang Yupeng , Yang Ziqiong , Huang Zongwu , Yin Panchao , Jiang Lingxiang , Zhang Rui , Tang Wen 
Published: December 2024

AbstractCross‐β structures are crucial in driving protein folding and aggregation. However, due to their strong aggregating tendency, the precise control of the self‐assembly of β‐sheet‐forming peptides remains a challenge. We propose a molecular geometry strategy to study and control the self‐assembly of cross‐β structures. We conjugate the peptide with shape‐persistent polyhedral oligomeric silsesquioxane (POSS), which acts as a hydrophilic head and senses the solvent environment. The POSS‐peptide amphiphiles display two distinct self‐assembly pathways: twisted nanoribbons transforming into either nanotubes at low water content or flat nanoribbons at high water content. The peptide packing in flat nanoribbons is predominantly modulated by POSS, diverting the system away from crystal formation, which is the absolute lowest energy state of pure peptide self‐assemblies. For the first time, we have demonstrated that POSS can serve as a useful tool to adjust the interactions between cross‐β strands, achieving fine‐tuning of the pathway complexity (i.e., the kinetic and thermodynamic aspects of peptide self‐assembly). With this versatile molecular platform incorporating multiple functionalities of POSS and programable peptide sequences, this study provides a platform to exploit cross‐β‐based nanomaterials with functional and pathological significance.
C−H Bond Activation by Sulfated Zirconium Oxide is Mediated by a Sulfur‐Centered Lewis Superacid
Authors: Jammee Ratchawi , Kolganov Alexander , Groves Marc C. , Pidko Evgeny A. , Sydora Orson L. , Conley Matthew P. 
Published: December 2024

AbstractSulfated zirconium oxide (SZO) catalyzes the hydrogenolysis of isotactic polypropylene (iPP, Mw=13.3 kDa, Đ=2.4, <mmmm>=94 %) or high‐density polyethylene (HDPE, Mn=2.5 kDa, Đ=3.6) to branched alkane products. We propose that this reactivity is driven by the pyrosulfate sites SZO, which open under mild conditions to transiently form adsorbed SO3 and sulfate groups. This adsorbed SO3 is a very strong Lewis acid that binds 15N‐pyridine or triethylphosphineoxide (TEPO) (ΔEads>−39 kcal mol−1), reacts with Ph3CH to form Ph3C+, and mediates H/D exchange in dihydroanthracene‐d4. DFT studies show that pyrosulfate sites open with a modest 26.1 kcal mol−1 barrier to form the adsorbed SO3 and sulfate in the presence of a tetramer of propylene. Hydride abstraction from the tertiary C−H in this model is exothermic and subsequent β‐scission forms cleaved products. Analysis of the energetics provided here brackets the hydride ion affinity (HIA) of the adsorbed SO3 between 226.2 to 237.9 kcal mol−1, among largest values reported for a formally neutral Lewis acid. This study explains how SZO, a classic heterogeneous catalyst, can form carbocations by a redox neutral hydride abstraction reaction by very strong Lewis sites.
Recessed Microelectrodes as a Platform to Investigate the Intrinsic Redox Process of Prussian Blue Analogs for Energy Storage Application
Authors: Jiyane Nomnotho , Santana Santos Carla , Echevarria Poza Igor , Palacios Corella Mario , Abdillah Mahbub Muhammad Adib , Marin‐Tajadura Gimena , Quast Thomas , Ibáñez Maria , Ventosa Edgar , Schuhmann Wolfgang 
Published: December 2024

AbstractThe determination of the intrinsic properties of solid active material candidates is essential for their performance optimization. However, macroscopic electrodes and related analytical techniques show challenges concerning the number of additional influencing parameters. We explore recessed microelectrodes (rME) as a platform that allows for a binder‐free investigation of Prussian Blue analogues (PBA), a family of promising battery materials. The enhanced diffusion using microelectrochemical tools is indispensable to assess the intrinsic material performance, overcoming the limitation of cation diffusion from the electrolyte to the solid interface during (dis)charging cycles and allowing the investigation of limiting steps in the coupled ion‐electron transfer process. The intrinsic electrochemical performance of PBAs was studied in a three‐electrode configuration by means of cyclic voltammetry and galvanostatic (dis)charging in aqueous Na+‐containing electrolyte. We extended the evaluation to the role of the electrolyte on the performance of cathodic and anodic processes of a Mn‐based PBA. Ex‐situ and operando chemical characterization were coupled to support the microelectrochemical results.
Understanding the awarding gap through the lived experiences of minority ethnic students: An intersectional approach
Authors: Gutman Leslie Morrison , Younas Fatima 
Published: December 2024

AbstractIn UK universities, there is a long‐standing gap in degree award outcomes for undergraduate students with white British students more likely to graduate with a ‘good degree’ (first or upper second class) than British students from minority ethnic backgrounds. Given its complex, systemic nature, researchers have highlighted the importance of adopting holistic, intersectional and exploratory approaches that are solution‐focused. However, few qualitative studies provide a voice to minoritised students with regards to describing their individual experiences and their own suggestions for change. Through interviews and an advisory group session, this qualitative study explores the lived experiences of 14 minority ethnic undergraduate female students attending a large, public research university in the UK. The findings generated key themes with intersectional dimensions including gender, nationality, immigrant status, socioeconomic status and educational background including biased attitudes and stereotypes, feelings of being underestimated and needing to work harder, the need for greater diversity, and feelings of disconnection and lack of integration with other minority ethnic students. Participants also shared their perceptions of the awarding gap and proposed strategies for addressing the gap, including raising awareness, increasing diversity among teaching staff, enhancing academic resources and fostering connection among peers. By capturing the racialised narratives of students, this research sheds light on the pervasive biases, stereotypes and systemic issues that contribute to the gap. Through these efforts, the study aims to foster a more inclusive and equitable educational environment, ultimately contributing to the elimination of the degree awarding gap at universities.
Recent Research on Chondrocyte Dedifferentiation and Insights for Regenerative Medicine
Authors: Su Weixian , Nie Yupeng , Zheng Shicong , Yao Yongchang 
Published: December 2024

ABSTRACTChondrocytes maintain the balance of the extracellular matrix by synthesizing glycoproteins, collagen, proteoglycans and hyaluronic acid. Chondrocyte dedifferentiation refers to a process in which chondrocytes lose their mature differentiated phenotype and transform into a fibroblast‐like morphology with fewer differentiated stages and inferior function under external stimulation. The important mechanism of homeostasis loss in osteoarthritis (OA) is a change in the chondrocyte phenotype. The dedifferentiation markers of chondrocytes are upregulated in OA, and the pathogenic factors related to OA have also been shown to enhance chondrocyte dedifferentiation. In this review, we compile recent studies on chondrocyte dedifferentiation, with an emphasis on potential markers and the underlying mechanisms of dedifferentiation, as well as the current research progress in inhibiting dedifferentiation or achieving redifferentiation. A deep understanding of chondrocyte dedifferentiation would not only support the pathogenesis of OA theoretically but also provide insightful ideas for regenerative medicine to manipulate the functional phenotype of cells.
Industrial Consumers Switching to Green Energy? An Application of the Theory of Market Choice Behaviour and Business Strategy
Authors: Sangroya Deepak , Joshi Yatish , Agarwal Reeti , Alghafes Rsha 
Published: December 2024

ABSTRACTStrategic green energy adoption by industrial customers could effectively address the worsening situation of the environment, which has largely impacted the well‐being of humans. To promote an understanding of the behaviour of the industrial green energy consumer and the impact of green energy strategy, this paper examines how multidimensional green perceived value (GPV) constructs relate to loyalty through customer satisfaction and perceived switching cost. The proposed conceptual model was empirically validated through data gathered from cross‐sectional responses of industrial energy consumers using green energy strategies for their business operations. Results indicated that GPV is a multidimensional formative higher‐order construct formed by social value, emotional value, functional value, and conditional value dimensions. Further, GPV impacts customer loyalty positively via the mediating effect of customer satisfaction and perceived switching costs. The current study found that an industrial consumer voluntarily uses green energy due to financial incentives alone, while social and emotional dimensions also play a major part in tactical decision‐making related to the implementation of green energy strategy.
Effects of humour‐logotherapy tailored to rural college students: A quasi‐experimental study
Authors: Do Eunna , Cho Sunhee 
Published: December 2024

AbstractObjectiveThis study aimed to examine the effects of humour‐logotherapy (HL) on meaning in life, perceived stress and depressive symptoms among rural college students in South Korea.Methods and MeasuresThe sample for a non‐randomised quasi‐experimental study comprised 40 college students. HL was operated in six sessions, lasted 90 min and included 10 min of humorous activities. The data were analysed using the IBM SPSS/WIN 23.0 for the χ2 test with Fisher's exact test, a t‐test, the Shapiro–Wilk test and a repeated measurement ANOVA.ResultsHL was effective in enhancing meaning in life (F = 6.52, p = .002) and reducing stress (F = 3.71, p = .029) and depressive symptoms (F = 3.26, p = .044). The effects of enhancing meaning in life and reducing stress persisted for 4 weeks; however, the effect of reducing depressive symptoms persisted for less than 4 weeks.ConclusionThe results suggest that HL can be used as an effective intervention for enhancing meaning in life, reducing stress and alleviating depression among rural college students.