bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Circulating Resistin Levels Linked to Increased Sarcopenia Risk in Older Adults
Authors: Kwak Mi Kyung , Baek Ji Yeon , Park So Jeong , Jung Hee-Won , Lee Eunju , Jang Il-Young , Ji Eunhye , Hong Eun-Gyoung , Jo Yunju , Ryu Dongryeol , Kim Beom-Jun 
Published: December 2024

Abstract

Context
Experimental evidence indicates that resistin, an adipokine, negatively impacts muscle metabolism by hindering myogenesis.

Objective
To explore resistin's potential as a biomarker of muscle health in humans by examining the relationship between circulating resistin levels and sarcopenia in older adults.

Design and Setting
A case-control study conducted in a geriatric clinical unit.

Participants
The study included 247 individuals aged 65 and older who underwent comprehensive geriatric evaluations.

Main Outcome Measures
Sarcopenia was defined based on Asian-specific thresholds, with serum resistin concentrations measured using an ELISA.

Results
After adjusting for sex, age, fat mass, smoking, osteoarthritis, and diabetes, participants with sarcopenia, low muscle mass, and weak muscle strength exhibited at least 27.0% higher circulating resistin concentrations than controls (P = .002-.003). Elevated serum resistin levels were inversely associated with skeletal muscle mass, gait speed, and the short physical performance battery score and positively associated with the time to complete 5 chair stands (P = .019-.048). Higher serum resistin levels were linked to an increased risk of sarcopenia, low muscle mass, and weak muscle strength (all P = .005). Finally, participants in the highest resistin quartile had at least 3 times higher odds of having adverse muscle outcomes compared to those in the lowest quartile (P = .007-.029).

Conclusion
This study set out to establish a link between blood resistin levels and sarcopenia, suggesting that circulating resistin may serve as a potential biomarker reflecting poor muscle health in humans.
EGFR Mutation Rates Correlate with Age at Diagnosis and Tumor Characteristics in Patients with Pulmonary Ground-Glass Opacities
Authors: Tang Wen-Fang , Qiu Zhen-Bin , Chu Xiang-Peng , Zeng Yu-Mei , Hu Yi-Bin , Tang Xuan , Yu Ye-Feng , Li Wen-Hao , Zhong Wen-Zhao , Huang Wei-Zhao , Liang Yi 
Published: December 2024

Abstract
Background
To clearly reveal the correlations between tumor characteristics, age at diagnosis, and epidermal growth factor receptor (EGFR) mutation rates in patients with pulmonary ground-glass opacities (GGOs).

Methods
We retrospectively reviewed 1473 patients with GGOs between January 2015 and May 2020 from two cancer centers. The tumor characteristics and EGFR mutation rates were compared between different age groups. Multivariate logistic regression was fitted to analyze the relationship between age, tumor characteristics, and EGFR mutation rates.

Results
The older patients had more large tumors, mixed GGOs with a consolidation-to-tumor ratio (CTR) of >0.5, and invasive adenocarcinoma (IAC) and pathologic stage IA2–IB. Overall, the rate of EGFR mutations in GGOs was 57.3% and the main subtypes were L858R and 19del mutations. The distribution of EGFR subtypes varied in different age and GGO diameter groups. Age (p = 0.036), GGO types (p = 0.005), tumor diameter (p = 0.039), and pathological types (p < 0.001) were significant predictors for EGFR mutation status. Importantly, significant differences in EGFR mutation rates between age groups were mainly observed in the GGO ≤2 cm diameter (p < 0.001), pure GGOs (p = 0.001), and IAC (p = 0.039) cohorts. Overall, those diagnosed at >50 years of age had a 47.0% increased likelihood of harboring EGFR mutations. Compared with the older group, the increased chance of harboring EGFR mutations for patients with larger tumors, mixed GGOs, and IAC was greater in the younger group.

Conclusions
The EGFR mutation rates were varied among different tumor characteristics and age at diagnosis. These findings provide new insights into the treatment of GGOs.
Parietal peritoneal hernia after abdominal hysterectomy for forty years: A case report
Authors: Chou Ya-Chen 
Published: December 2024

BACKGROUND
Internal hernia is a rare complication following abdominal surgery, primarily resulting from structural defects caused by anastomosis. We report a unique case of a late abdominal wall internal hernia highly suspected as resulting from insufficient peritoneal closure.
CASE SUMMARY
A 72-year-old woman presented with symptoms of intestinal obstruction 40 years after undergoing an abdominal hysterectomy. Abdominal computed tomography revealed a suspicious closed loop of intestine; then, a laparotomy was performed for suspected internal hernia. During the procedure, herniation of intestine into the preperitoneal space through a parietal peritoneal defect between rectus abdominis and sigmoid colon was identified. Intestinal reduction, resection of the ischemic segment and closure of the peritoneal defect were performed. The patient recovered well.
CONCLUSION
Non-closure of peritoneum might lead to late internal hernias. Meticulous peritoneal closure should be considered to prevent this potentially lethal complication.
Board Chairman Characteristics and Performance of Islamic Banks: Evidence From Islamic Banks in Indonesia and Malaysia
Authors: Quddus Ayatullah , Utama Imron , Rosadi Samsul , Rahmawati Aryani 
Published: December 2024

Purpose: The purpose of this study is to explore the impact of chairman characteristics—specifically age, gender, and education level—on the performance of Islamic banks in Indonesia and Malaysia. The motivation for this research stems from the limited and mixed findings in existing literature regarding the role of leadership traits in shaping bank performance, especially in the context of Islamic banking. This research aims to fill the gap by analyzing how these specific characteristics influence the strategic decisions and overall performance of banks in these two countries, which are home to some of the largest Islamic banks globally. The key finding of this study is that while the age of the chairman significantly impacts performance, gender and education level do not show a notable effect.
Methodology: The study employed a quantitative research methodology, using panel data from Islamic banks in Indonesia and Malaysia from 2015-2020. A panel data regression model was utilized to assess the influence of chairman characteristics on bank performance based on financial indicators such as return on assets (ROA). Data were collected from publicly available financial reports over a period of several years, and the characteristics of each chairman, such as age, gender, and education level, were analyzed in relation to these performance.
Findings: The results of the regression analysis show that the age of the chairman has a significant positive relationship with bank performance. Older chairmen appear to contribute to better decision-making and long-term strategy formulation, which in turn improves the performance of Islamic banks. However, the gender and education level of the chairman were found to have no significant impact on the performance of these banks during the research period. This suggests that experience, reflected in age, plays a more crucial role than gender or educational background in determining bank performance.
Novelty: This study provides valuable insights into the role of leadership chairman characteristics in Islamic banks, with a focus on the importance of age as a key predictor of bank performance. By contrasting the effect of age with gender and education, this research contributes to the ongoing debate about leadership in the financial sector. The novelty lies in its focus on the specific context of Islamic banks in Indonesia and Malaysia, offering a regional perspective on how leadership traits influence bank success. Future research could further explore additional leadership traits or examine a larger dataset across different regions to strengthen these findings.
Ternary molybdate Rb5(Ag1/3Hf5/3)(MoO4)6: synthesis, structure, thermal expansion and ionic conductivity
Authors: Subanakov Alexey , Tushinova Yunna , Kovtunets Evgeny , Spiridonova Tatyana , Bazarov Bair 
Published: December 2024

This study aims to characterize the properties of the ternary molybdate Rb5(Ag1/3Hf5/3)(MoO4)6, which was previously identified during phase equilibrium investigations in the Ag2MoO4–Rb2MoO4–Hf(MoO4)2 system. A ternary molybdate Rb5(Ag1/3Hf5/3)(MoO4)6 was obtained through a solid-state reaction. It was found that the compound crystallizes in the trigonal space group R c and melts at 596 °C with decomposition. Its structure was refined using the Rietveld method. The crystal structure consists of a mixed framework composed of isolated (Ag/Hf)O6 octahedra and MoO4 tetrahedra, interconnected through shared oxygen vertices. Large voids within the framework accommodate two types of rubidium atoms. Using the powder XRD data recorded over 30–400 °C, the principal components of the thermal expansion tensor were determined. Rb5(Ag1/3Hf5/3)(MoO4)6 can be classified as a material with high thermal expansion coefficient (αV = 36.7∙10–6 °С–1 at 400 °C). At elevated temperatures, the compound exhibited significant ionic conductivity, reaching 1.7·10−3 S/cm at 480 °C with an activation energy Еа = 0.8 eV with oxygen ions as the probable charge carriers. Energy barriers for one-, two-, and three-dimensional transport in the compound were theoretically evaluated using the softBV program and bond valence sum maps (BVS).
Suplementação oral de prebiótico, mananoligossacarídeo, mitiga disbiose intestinal em ratos jovens cronicamente expostos ao tabagismo passivo
Authors: Silva Bruna Rafaela dos Santos , Gonçalves Robson Diego Silva , Sasso Vanessa Teixeira Paolino , Bremer-Neto Hermann , Keller Rogeria 
Published: December 2024

In humans, passive smoking has been shown to alter the microbiota and increase the risk of infections by pathogens and/or opportunistic bacteria. The objective of this study was to evaluate the effect of MOS supplementation on the concentration of E. coli in the feces of passive smoking rats. Sixty young rats (23 days) were randomly allocated into four groups (n=15): supplemented or not with MOS in the diet; and chronically exposed or not to cigarette smoke. Exposure to cigarette smoke was performed twice a day for 180 days and fecal samples were collected four times (days 0, 60, 120, and 180). After fecal collection, bacterial populations were amplified by real-time PCR. Data means were analyzed using one-way ANOVA followed by Student-Newman-Keuls post-hoc analysis, considering 5% as the level of significance. The results revealed that MOS supplementation significantly (P<0.05) reduced the E. coli population resulting from chronic exposure to cigarette smoke. The mean results of the group of rats supplemented with MOS and exposed to cigarette smoke did not differ (P>0.05) from the groups not exposed to cigarette smoke and supplemented or not with MOS. The results allow us to conclude that MOS supplementation mitigates the chronic effect of cigarette smoke on the concentration of E. coli bacteria in young rats, as a preclinical model.
Genetic thrombophilia and antiphospholipid antibodies in women with early and late preeclampsia: a retrospective cohort study
Authors: Antonova A. S. , Khizroeva J. Kh. , Bitsadze V. O. , Tretyakova M. V. , Makatsariya N. A. , Efendieva E. R. , Shatilina A. Yu. , Lyadnova E. M. 
Published: December 2024

Aim: to study a pattern of genetic and acquired thrombophilia in pregnant women with severe early-onset (eoPЕ) and severe late-onset PE (loPЕ) preeclampsia (PE).Materials and Methods. A retrospective cohort study was conducted from January 2022 to May 2024. A total of 109 pregnant women were examined: group 1 – 45 women with eoPЕ (< 34 weeks of pregnancy), group 2 – 24 women with loPЕ (≥ 34 weeks of pregnancy), group 3 (control) – 40 women with physiologically uncomplicated pregnancy. All pregnant women were examined for lupus anticoagulant (LA) and antiphospholipid antibodies (aPL). The screening test for aPL included the quantitation of IgG/IgM antibodies against cardiolipin, phosphatidylserine, phosphatidylinositol, phosphatidic acid, and β2-glycoprotein 1 in serum or plasma using an enzyme immunoassay. Genetic thrombophilia, homocysteine, and ADAMTS-13 metalloproteinase (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) levels were also determined.Results. Pregnant women with severe PE more often had genetic forms of thrombophilia (mutations in factor (F) V Leiden gene, prothrombin G20210A, and Thr165Met) and a deficiency of natural anticoagulants (antithrombin and protein S) compared to pregnant women in control group. Women in eoPE vs. loPE group were more often found to carry genetic polymorphisms in the plasminogen activator inhibitor-1 (PAI-1) and fibrinogen genes. Also, in the group of pregnant women with eoPE, the circulation of aPL, ADAMTS-13 inhibitor, and elevated homocysteine levels were more common. Pregnant women with loPE were older and more often suffered from hypertension, diabetes mellitus, and excess body weight. No significant differences between eoPЕ and loPЕ groups were found while comparing prevalence of autoimmune diseases, thrombosis in familial history, mutations in FV Leiden gene (heterozygous form), FII prothrombin gene G20210A (homozygous form), FII prothrombin gene Thr165Met (heterozygous form), antithrombin III deficiency, protein S deficiency.Conclusion. Precise causes underlying PE remain unknown, and we are still far from understanding all the molecular, immunological, genetic, and environmental mechanisms that lead to the various clinical manifestations of placental syndromes including PE. However, the study results suggest that the presence of thrombophilic disorders, especially in the fibrinolytic system, and aPL circulation contribute to eoPE pathophysiology or progression.
Study of clinical profile and laboratory markers in early diagnosis of severe dengue in children
Authors: Srinivas Suprith Amblihalli , Pol Ramesh 
Published: December 2024

Background: Dengue fever is a mosquito-borne viral disease that presents as asymptomatic or can clinically manifest with symptoms like hemorrhagic fever and shock. Alteration of various other hematological parameters includes leukopenia, thrombocytopenia, hematocrit changes, and liver enzyme alteration. this study aimed to investigate dengue patients' clinical profiles, laboratory parameters, and outcomes across different severity levels.
Methods: This is a prospective hospital-based study of 125 patients conducted at S. Nijalingappa medical college, Bagalkot over 18 months from August 2022 to February 2024. the study included 125 cases with serologically confirmed (NS1ag and/ IgM) between 1 to 14 years and categorized according to WHO classification.
Results: Out of 125 patients, 62 and 33 had dengue with and without warning signs, and 30 had severe dengue, 52% of cases had leucopenia, and thrombocytopenia was present in 105 (84%) cases with significantly higher in severity groups. Elevated SGOT 108 (86.4%) and SGPT 72 (57.6%) were commonly seen in disease severity groups. Liver dysfunction was observed in 86.4% of patients. All patients survived and improved with appropriate treatment.
Conclusions: This study highlights the importance of clinical and hematological parameters in the early recognition and management of severe dengue cases. Liver dysfunction was common in severe cases. Despite the varying severity, all patients in this cohort had favorable outcomes, emphasizing the effectiveness of proper management strategies.
Variations in physiological responses to painful stimuli in preterm and term neonates: an observational study
Authors: Agrawal Pranav , Samayam Purnima 
Published: December 2024

Background: Appropriate neonatal pain assessment and management is a key component of quality medical care. Assessment of pain, however, is a challenge due to their inability to verbalize this subjective sensation. Preterms are hyper-sensitive to pain and experience it for prolonged periods but it is postulated that they may not express it as robustly and reliably as term neonates. This paper aims to assess and compare the behavioral and physiological pain responses in these groups.
Methods: This prospective observational study was conducted in the outpatient and post-natal wards of a tertiary care teaching hospital. 90 clinically stable term and late preterm neonates requiring IV cannulation, IV blood sampling or heel prick were included. NIPS Pain Scale Scores and physiological parameters (heart rate, respiratory rate, SpO2, mean arterial pressure, total crying time) were recorded before and after the procedure.
Results: 90 neonates were analysed. Significant pain response was noted in both groups post-procedure. In response to the same procedures, preterm neonates demonstrated lower NIPS Scores (4.00 vs. 4.93, P=0.003) and shorter cry times (64.30s vs. 87.35s, P=<0.05). Also noted were higher heart rates and respiratory rates with a prolonged fall in SpO2 and Mean Arterial Pressures in this group.
Conclusions: Preterms, compared to term neonates demonstrate a blunted behavioral response to pain but a heightened and prolonged physiological response. This potential underestimation of pain in preterms indicate the need for incorporation of behavioral cues, physiological parameters and gestational age in the assessment of pain in newborns.
Training of specialists for personalized medicine in a modern medical university
Authors: Sirotkina O. V. , Vavilova T. V. , Kukharchik G. A. , Parmon E. V. , Pospelova M. L. , Lipatova E. G. 
Published: December 2024

Training staff in personalized medicine implies modernisation of the traditional learning model that is to incorporate a curricular thread spanning all the stages (pre-university, undergraduate, post-graduate) of a doctor’s professional development.The article presents the experience of the Institute of Medical Education of The Almazov National Medical Research Centre in training personnel prepared to implement the principles of personalized medicine in domestic healthcare.
Identifying factors that exacerbate frailty using the Kihon Checklist: A six-year longitudinal study among Japanese residents
Authors: Imai Norio , Homma Daisuke , Horigome Yoji , Yoda Takuya , Murakami Reiko , Fujii Toshihide , Ohashi Masayuki , Kawashima Hiroyuki 
Published: December 2024

Abstract

Aim
This study aimed to identify factors preventing or exacerbating frailty using the Kihon Checklist (KCL).
Methods
This non-interventional, retrospective study included participants aged 70 years in 2016 and 76 years in 2022 and evaluated health status using the KCL. Multivariate logistic regression analysis was performed to identify independently associated factors for participants who remained robust from 2016 to 2022; those who were robust in 2016 but transitioned to pre-frailty by 2022; and those who were frail in 2016 but improved to pre-frailty or robustness by 2022.
Results
Key factors associated with maintaining robustness included occasional visits to friends and not having fear of falling while walking. From 2016 to 2022, indicators of transitioning from robustness to pre-frailty included changes from “yes” to “no” for climbing stairs without any support, “no” to “yes” for having difficulty in eating tough foods, and “no” to “yes” for not knowing the date. Factors associated with transitioning from robustness to frailty included “yes” to body mass index remaining < 18.5 kg/m2, “no” to going out at least once a week, and “yes” to having difficulty in doing what the respondent could previously do easily. An independent factor indicating improvement from frailty to robustness or pre-frailty was change from “no” to “yes” to going out at least once a week.
Conclusions
Regularly going out was a key factor for preventing frailty and improving status from frailty to pre-frailty or robustness, underscoring the importance of targeted interventions for at-risk elderly individuals to sustain robustness and delay frailty.
Factors and prevalence of musculoskeletal pain among the App-based food delivery riders in Tamil Nadu: A cross-sectional study
Authors: M Benson Thomas , Sathiyarajeswaran Narrain Shree , Radhakrishnan R. , A Abdul Gaffoor , Krupalakshme M. , Samal Janmejaya 
Published: December 2024

Abstract

Objectives
The main objectives of this study were to estimate the prevalence of pain, discomfort, and injuries among app-based food delivery riders in Tamil Nadu.
Methods
A cross-sectional study was conducted among 425 app-based male food delivery riders in Tamil Nadu. The data was collected from June to July 2023 using the Nordic Musculoskeletal Questionnaire to assess physical pain, discomfort, and injuries.
Results
Among 425 food delivery riders chronic pain persisting over 12 months is prevalent among food delivery riders, notably affecting the lower back (49.18%), upper back (39.53%), neck (28.71%), and shoulders (26.12%). Short-term pain was reported by 56% of the respondents in the lower back in the last week. Substance use, dehydration, and work location are significantly associated with long- and short-term pains. The knees, Ankles and wrists are the most common body sites of injuries and skipping meals during duty hours is significantly associated with injuries.
Conclusions
Research in the area of assessing the pain and injuries among food delivery riders is minimal. The present study, notably, extends the understanding of the health impact of full-time food delivery work by revealing a high prevalence of physical pain, particularly in the lower back.
Effectiveness of a Family-Management Program for Family having Children with Acute Lymphoblastic Leukemia: A Quasi-Experimental Study
Authors: Aungkaprasatchai Wachareekorn , Chaimongkol Nujjaree , Hengudomsub Pornpat , Hendricks-Ferguson Verna L. 
Published: December 2024

Abstract

Purpose
To examine effectiveness of a family-management program (FMP) on family management, family, and child quality of life (QOL) among parents of children with Acute Lymphoblastic Leukemia (ALL).
Methods
Participants included 46 parents of children with ALL recruited through a convenience sampling method from a tertiary hospital in Thailand. Twenty-three intervention participants received a 3-weekly FMP and routine care while the other 23 control participants received only the routine care. Data were carried out at the hospital site and telephone follow-up. The study outcomes were evaluated at 3 times points (i.e. baseline, post-intervention, and follow-up) using the Family Management Measure, the Beach Center Family Quality of Life Scale, and the Quality Of Life of Children with cancer module. Data were analyzed using two-way repeated measures analysis of variance (ANOVA).
Results
The findings revealed that family management and child QOL in the intervention group were higher than that in the control group at follow-up (p < .05), but not for family QOL. Within the intervention group, there was significant improvement in family management, family QOL and child QOL at post-intervention and follow-up.
Conclusions
The FMP was effective in that it could increase outcomes among the parents of children with ALL after receiving the program comparing to those who did not. Healthcare providers, especially clinical nurses who work with parents having children with ALL could utilize the FMP to help them achieve optimal family management, family QOL and child QOL.