bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 vaccine hesitancy among medical students in India
Authors: Jain Jyoti , Saurabh Suman , Kumar Prashant , Verma Mahendra Kumar , Goel Akhil Dhanesh , Gupta Manoj Kumar , Bhardwaj Pankaj , Raghav Pankaja Ravi 
Published: May 2021

Abstract
The coronavirus disease 2019 (COVID-19) vaccine was launched in India on 16 January 2021, prioritising health care workers which included medical students. We aimed to assess vaccine hesitancy and factors related to it among medical students in India. An online questionnaire was filled by 1068 medical students across 22 states and union territories of India from 2 February to 7 March 2021. Vaccine hesitancy was found among 10.6%. Concern regarding vaccine safety and efficacy, lack of awareness regarding their eligibility for vaccination and lack of trust in government agencies predicted COVID-19 vaccine hesitancy among medical students. On the other hand, the presence of risk perception regarding themselves being affected with COVID-19 reduced vaccine hesitancy as well as hesitancy in participating in COVID-19 vaccine trials. Vaccine-hesitant students were more likely to derive information from social media and less likely from teachers at their medical colleges. Choosing between the two available vaccines (Covishield and Covaxin) was considered important by medical students both for themselves and for their future patients. Covishield was preferred to Covaxin by students. Majority of those willing to take the COVID-19 vaccine felt that it was important for them to resume their clinical posting, face-to-face classes and get their personal life back on track. Around three-fourths medical students viewed that COVID-19 vaccine should be made mandatory for both health care workers and international travellers. Prior adult vaccination did not have an effect on COVID-19 vaccine hesitancy. Targeted awareness campaigns, regulatory oversight of vaccine trials and public release of safety and efficacy data and trust building activities could further reduce COVID-19 vaccine hesitancy among medical students.
The Invention of an Opera House: The 1844 Teatro Victoria in Valparaiso, Chile
Authors: Izquierdo König José Manuel 
Published: May 2021

AbstractThe 1844 Teatro Victoria in Valparaiso, Chile, can be considered the first purpose-built opera house in the Andean region of the Americas. Managed by impresario Pietro Alessandri, it became the centre of an early operatic scene in the South Pacific and a model for theatres built during the following decades. In this article, I discuss the Teatro Victoria as an opera house and the way in which it functioned on the borders of what was then a new global operatic scene. Latin American research on opera has focused mostly on singers and performances, rather than on the workings of the opera houses and the operatic scene. This article discusses the rationale behind the development of the Teatro Victoria project, some of the strategies underpinning its success and the notion of this particular opera house as a projection of certain ideas of ‘Italian culture’ and networks. The article shows, first, that the successful reception and appropriation of Italian opera in this period was not necessarily guaranteed, and it differed across the Americas. Second, that local brokers and host communities had key roles in shaping that reception, which can easily be perceived as a passive one when looked at only from the perspective of the singers or the music itself.
Global leadership in paediatric and congenital cardiac care: “Humility in Leadership – an interview with Katarina Hanséus, MD, PhD, President of the Association for European Paediatric and Congenital Cardiology (AEPC)”
Authors: Tretter Justin T. , Jacobs Jeffrey P. 
Published: May 2021

AbstractDr. Katarina Hanséus is the focus of our fourth in a series of interviews in Cardiology in the Young entitled, “Global Leadership in Paediatric and Congenital Cardiac Care”. Dr. Hanséus was born in Malmö, Sweden. She attended undergraduate school in her home town in Malmö, Sweden, graduating in 1974. Dr. Hanséus then went on to complete medical school at University of Lund in Lund, Sweden, graduating in 1980, where additionally she completed a Doctoral Dissertation in the evaluation of cardiac function and chamber size in children using Doppler and cross-sectional echocardiography. Under the Swedish Board of National Welfare, Dr. Hanséus completed her authorisation as a paediatrician in 1986, followed by her authorisation as a paediatric cardiologist in 1988, at University of Lund. She was appointed head of Paediatric Cardiology in 2000 at the Children’s Heart Center, Skane University Hospital, Lund, Sweden. The programme at Lund serves as one of the two national referral centres for comprehensive paediatric and congenital cardiac care, including paediatric cardiac surgery, in Sweden. From 2006 to 2013, she served as the clinical and administrative head of the Department of Neonatology, Paediatric Surgery, Paediatric Intensive Care, Paediatric Cardiology, and Paediatric Cardiac Surgery, returning as the head of Paediatric Cardiology in 2013, for which she currently holds the position.Dr. Hanséus is a recognised leader in the field of Paediatric Cardiology and has been involved in leadership within the Swedish Pediatric Society, the Swedish Association for Pediatric Cardiology, and the Association for European Paediatric and Congenital Cardiology throughout her career. Within the Association for European Paediatric and Congenital Cardiology, she served as the Secretary General from 2011 to 2016, the President Elect in 2018, and is the current President serving from 2019 until 2022. This article presents our interview with Dr. Hanséus, an interview that covers her experience as a leader in the field of Paediatric Cardiology, including the history and goals of the Association for European Paediatric and Congenital Cardiology, and her role and vision as their current President.
Low dietary protein increases vitamin A absorption and deposition into milk in periparturient rats
Authors: Laarman Anne H. , Watts Jason S. , Foroudi Farhad , Rezamand Pedram 
Published: May 2021

Abstract: Our objective was to study the effect of differing dietary crude protein and vitamin A on retinoid metabolism in a periparturient rat model. Sixty female rats, approximately 21 d before parturition, were fed rations containing either low protein (13%; LP) or high protein (22%; HP) crude protein and either low vitamin A (3 IU/g; LA) or high vitamin A (5 IU/g; HA), yielding treatments HPHA, HPLA, LPHA, and LPLA. Samples were collected at d −14, d +3, and +10 relative to parturition and analyzed for all-trans retinoid acid (RA), 13-Cis RA, and retinol. At d −14, serum all-trans RA concentrations decreased compared to baseline. At both d +3 and d +10, serum retinol increased and liver 13-Cis RA decreased. In the small intestine, 13-cis RA was higher in HPHA than HPLA pre-partum (0.93±0.12 vs. 0.40±0.12 ng/ml, P=0.04). Post-partum, 13-cis RA was lower in high vitamin HPHA and LPHA groups (0.35±0.06 and 0.38±0.06 ng/ml) than in low vitamin A HPLA and LPLA treatments (0.50±0.06 and 1.32±0.06 ng/ml, P<0.01). In rats fed LA diets, TNF-alpha expression tended to be lower in HPLA than LPLA groups on day +3 (0.69±0.34 vs 1.00±0.52, P=0.08), but not day +10 (0.56±0.25 vs. 1.00±0.49 fold change, P>0.10). Retinoids accumulated during pregnancy and were mobilized during lactation. The sequestration of retinoids was increased when dietary protein content was low. Further studies are needed to investigate how retinoid metabolism could be manipulated to improve vitamin A delivery to milk.
Midwest US Croplands Determine Model Divergence in North American Carbon Fluxes
Authors: Sun Wu , Fang Yuanyuan , Luo Xiangzhong , Shiga Yoichi P. , Zhang Yao , Andrews Arlyn E. , Thoning Kirk W. , Fisher Joshua B. , Keenan Trevor F. , Michalak Anna M. 
Published: May 2021

AbstractLarge uncertainties in North American terrestrial carbon fluxes hinder regional climate projections. Terrestrial biosphere models (TBMs), the essential tools for understanding continental‐scale carbon cycle, diverge on whether temperate forests or croplands dominate carbon uptake in North America. Evidence from novel photosynthetic proxies, such as those based on chlorophyll fluorescence, has cast doubt on the “weak cropland, strong forest” carbon uptake patterns simulated by most TBMs. However, no systematic evaluation of TBMs has yet been attempted to pin down space‐time patterns that are most consistent with regional CO2 observational constraints. Here, we leverage atmospheric CO2 observations and satellite‐observed photosynthetic proxies to understand emergent space‐time patterns in North American carbon fluxes from a large suite of TBMs and data‐driven models. To do so, we evaluate how well the atmospheric signals resulting from carbon flux estimates reproduce the space‐time variability in atmospheric CO2, as is observed by a network of continuous‐monitoring towers over North America. Models with gross or net carbon fluxes that are consistent with the observed CO2 variability share a salient feature of growing‐season carbon uptake in Midwest US croplands. Conversely, the remaining models place most growing‐season uptake in boreal or temperate forests. Differences in model explanatory power depend mainly on the simulated annual cycles of cropland uptake—especially, the timing of peak uptake—rather than the distribution of annual mean fluxes across biomes. Our results suggest that improved model representation of cropland phenology is crucial to robust, policy‐relevant estimation of North American carbon exchange.
Subducted Lithosphere Under South America From Multifrequency P Wave Tomography
Authors: Mohammadzaheri Afsaneh , Sigloch Karin , Hosseini Kasra , Mihalynuk Mitchell G. 
Published: May 2021

AbstractWe analyze mantle structure under South America in the DETOX‐P1 seismic tomography model, a global‐scale, multifrequency inversion of teleseismic P waves. DETOX‐P1 inverts the most extensive data set of broadband, waveform‐based traveltime measurements to date, complemented by analyst‐picked traveltimes from the ISC‐EHB catalog. The mantle under South America is sampled by ∼665,000 cross‐correlation traveltimes measured on 529 South American broadband stations and on 5,389 stations elsewhere. By their locations, depths, and geometries, we distinguish four high‐velocity provinces under South America, interpreted as subducted lithosphere (“slabs”). The deepest (∼1,800–1,200 km depth) and shallowest (<600 km) slab provinces are observed beneath the Andean Cordillera near the continent’s northwest coast. At intermediate depths (1,200–900 km, 900–600 km), two slab provinces are observed farther east, under Brazil, Bolivia and Venezuela, with links to the Caribbean. We interpret the slabs relative to South America’s paleo‐position over time, exploring the hypothesis that slabs sank essentially vertically after widening by viscous deformation in the mantle transition zone. The shallowest slab province carries the geometric imprint of the continental margin and represents ocean‐beneath‐continent subduction during Cenozoic times. The deepest, farthest west slab complex formed under intra‐oceanic trenches during late Jurassic and Cretaceous times, far west of South America’s paleo‐position adjoined to Africa. The two intermediate slab complexes record the Cretaceous transition from westward intra‐oceanic subduction to eastward subduction beneath South America. This geophysical inference matches geologic records of the transition from Jura‐Cretaceous, extensional “intra‐arc” basins to basin inversion and onset of the modern Andean arc ∼85 Ma.
Seasonal Variations in Moisture Origin Explain Spatial Contrast in Precipitation Isotope Seasonality on Coastal Western Greenland
Authors: Cluett A. A. , Thomas E. K. , Evans S. M. , Keys P. W. 
Published: May 2021

AbstractIncreased precipitation in the Arctic is a robust feature across model simulations of the coming century, driven by intensification of meridional moisture transport and enhanced local evaporation in the absence of sea ice. These mechanisms are associated with distinct, seasonal, spatial, and, likely, precipitation isotope (δ2HPrecip) expressions. Historical observations of δ2HPrecip reveal a contrast in seasonality between southwestern and northwestern coastal Greenland: δ2HPrecip in northwestern Greenland varies in phase with local temperature, whereas δ2HPrecip in southwestern Greenland is decoupled from local temperature and exhibits little seasonal variation. We test the hypothesis that reduced δ2HPrecip seasonality in southwestern Greenland relative to northwestern Greenland results from dynamic moisture source variations, by diagnosing monthly average moisture sources to three sink regions (Kangilinnguit, Ilulissat, and Qaanaaq) using the Water Accounting Model‐2layers model. All domains demonstrate strong intra‐annual moisture source variations. Moisture to the southernmost region is sourced most remotely in summer and most locally in winter, associated with stronger cooling from the source in summer than winter, promoting more negative δ2HPrecip and counteracting local temperature‐driven seasonality. In comparison, moisture transport distance to the northernmost region is relatively constant, as local sea ice restricts northward migration of the winter moisture source. We simulate seasonal patterns in δ2HPrecip in a simple Rayleigh model, which confirm the importance of source temperature and starting isotopic compositions in determining δ2HPrecip for these regions. δ2HPrecip sensitivity to moisture source variability suggests these coastal Arctic settings may yield paleoclimate records sensitive to the moisture transport processes predicted to amplify future precipitation.
Episodic Earthquake Swarms in the Mineral Mountains, Utah Driven by the Roosevelt Hydrothermal System
Authors: Mesimeri Maria , Pankow Kristine L. , Baker Ben , Hale J. Mark 
Published: May 2021

AbstractOver 1,000 earthquakes (−2.0 < M < 2.0), identified using a matched‐filter method, occurred in the Mineral Mountains, Utah between 2016 and 2019. The enhanced catalog is complete down to M −0.9 and contains roughly 15 times more events than originally cataloged. Earthquake relocation of ∼800 earthquakes shows that activity is concentrated in a <2 km long E‐W striking narrow zone, ∼4 km east of the Roosevelt hydrothermal system. Two fault orientations, both N‐S and E‐W parallel to the Opal Mound and Mag Lee faults, respectively, are observed after computing composite focal mechanisms of highly similar earthquakes. Looking solely at the temporal distribution of the seismicity, we identify 15 periods of swarm‐like activity, with two major clusters occurring in December 2016, recorded by three stations, and in October 2019 recorded by eight stations. The October 2019 swarm, the best recorded sequence in the area, provides evidence for the underlying triggering mechanism. We show that a complex mechanism of fluid diffusion and aseismic slip is responsible for the swarm evolution with migration velocities reaching 10 km/day. We hypothesize that these episodic swarms in the Mineral Mountains are primarily driven by migrating fluids that originate within the Roosevelt hydrothermal system.
Exosomal microRNA-503-3p derived from macrophages represses glycolysis and promotes mitochondrial oxidative phosphorylation in breast cancer cells by elevating DACT2
Authors: Huang Shulin , Fan Peizhi , Zhang Chaojie , Xie Jing , Gu Xiaowen , Lei Shanshan , Chen Zihua , Huang Zhongcheng 
Published: May 2021

AbstractMicroRNAs (miRNAs) are emerging drivers in tumor progression, while the role of miR-503-3p in breast cancer (BC) remains largely unknown. We aimed to explore the impact of macrophage-derived exosomal miR-503-3p in the development of BC by regulating disheveled-associated binding antagonist of beta-catenin 2 (DACT2). miR-503-3p and DACT2 expression in BC tissues and cells was assessed, and the expression of Wnt/β-catenin signaling pathway-related proteins in BC cells was also evaluated. Macrophages were induced and exosomes were extracted. The screened BC cell lines were, respectively, treated with exosomes, miR-503-3p inhibitor/mimic or upregulated/inhibited DACT2, and then the phenotypes, glucose intake, oxygen consumption rate, and adenosine-triphosphate (ATP) level of BC cells were determined. Cell growth in vivo was also observed. MiR-503-3p was elevated, DACT2 was reduced, and Wnt/β-catenin signaling pathway was activated in BC cells. Macrophage-derived exosomes, upregulated miR-503-3p or inhibited DACT2 promoted malignant behaviors of BC cells, glucose intake, and activity of the Wnt/β-catenin signaling pathway, while repressed oxygen consumption rate and ATP level in BC cells. Reversely, reduced miR-503-3p or upregulated DACT2 exerted opposite effects. This study revealed that reduction of macrophage-derived exosomal miR-503-3p repressed glycolysis and promoted mitochondrial oxidative phosphorylation in BC by elevating DACT2 and inactivating Wnt/β-catenin signaling pathway. Our research may provide novel targets for BC treatment.
Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells
Authors: Fang Chieh-Ting , Kuo Hsiao-Hui , Yuan Chia-Jung , Yao Jhong-Syuan , Yih Ling-Huei 
Published: May 2021

AbstractTaxol is a first-line chemotherapeutic for numerous cancers, including the highly refractory triple-negative breast cancer (TNBC). However, it is often associated with toxic side effects and chemoresistance in breast cancer patients, which greatly limits the clinical utility of the drug. Hence, compounds that act in concert with taxol to promote cytotoxicity may be useful to improve the efficacy of taxol-based chemotherapy. In this study, we demonstrated that mdivi-1, a putative inhibitor of mitochondrial fission protein Drp1, enhances the anticancer effects of taxol and overcomes taxol resistance in a TNBC cell line (MDA-MB-231). Not only did mdivi-1 induce mitotic spindle abnormalities and mitotic arrest when used alone, but it also enhanced taxol-induced antimitotic effects when applied in combination. In addition, mdivi-1 induced pronounced spindle abnormalities and cytotoxicity in a taxol-resistant cell line, indicating that it can overcome taxol resistance. Notably, the antimitotic effects of mdivi-1 were not accompanied by prominent morphological or functional alterations in mitochondria and were Drp1-independent. Instead, mdivi-1 exhibited affinity to tubulin at μM level, inhibited tubulin polymerization, and immediately disrupted spindle assembly when cells entered mitosis. Together, our results show that mdivi-1 associates with tubulin and impedes tubulin polymerization, actions which may underlie its antimitotic activity and its ability to enhance taxol cytotoxicity and overcome taxol resistance in MDA-MB-231 cells. Furthermore, our data imply a possibility that mdivi-1 could be useful to improve the therapeutic efficacy of taxol in breast cancer.
Phase-to-pattern inverse design paradigm for fast realization of functional metasurfaces via transfer learning
Authors: Zhu Ruichao , Qiu Tianshuo , Wang Jiafu , Sui Sai , Hao Chenglong , Liu Tonghao , Li Yongfeng , Feng Mingde , Zhang Anxue , Qiu Cheng-Wei , Qu Shaobo 
Published: May 2021

AbstractMetasurfaces have provided unprecedented freedom for manipulating electromagnetic waves. In metasurface design, massive meta-atoms have to be optimized to produce the desired phase profiles, which is time-consuming and sometimes prohibitive. In this paper, we propose a fast accurate inverse method of designing functional metasurfaces based on transfer learning, which can generate metasurface patterns monolithically from input phase profiles for specific functions. A transfer learning network based on GoogLeNet-Inception-V3 can predict the phases of 28×8 meta-atoms with an accuracy of around 90%. This method is validated via functional metasurface design using the trained network. Metasurface patterns are generated monolithically for achieving two typical functionals, 2D focusing and abnormal reflection. Both simulation and experiment verify the high design accuracy. This method provides an inverse design paradigm for fast functional metasurface design, and can be readily used to establish a meta-atom library with full phase span.
Structural insights on ligand recognition at the human leukotriene B4 receptor 1
Authors: Michaelian Nairie , Sadybekov Anastasiia , Besserer-Offroy Élie , Han Gye Won , Krishnamurthy Harini , Zamlynny Beata A. , Fradera Xavier , Siliphaivanh Phieng , Presland Jeremy , Spencer Kerrie B. , Soisson Stephen M. , Popov Petr , Sarret Philippe , Katritch Vsevolod , Cherezov Vadim 
Published: May 2021

AbstractThe leukotriene B4 receptor 1 (BLT1) regulates the recruitment and chemotaxis of different cell types and plays a role in the pathophysiology of infectious, allergic, metabolic, and tumorigenic human diseases. Here we present a crystal structure of human BLT1 (hBLT1) in complex with a selective antagonist MK-D-046, developed for the treatment of type 2 diabetes and other inflammatory conditions. Comprehensive analysis of the structure and structure-activity relationship data, reinforced by site-directed mutagenesis and docking studies, reveals molecular determinants of ligand binding and selectivity toward different BLT receptor subtypes and across species. The structure helps to identify a putative membrane-buried ligand access channel as well as potential receptor binding modes of endogenous agonists. These structural insights of hBLT1 enrich our understanding of its ligand recognition and open up future avenues in structure-based drug design.
Autocatalytic and oscillatory reaction networks that form guanidines and products of their cyclization
Authors: Novichkov Alexander I. , Hanopolskyi Anton I. , Miao Xiaoming , Shimon Linda J. W. , Diskin-Posner Yael , Semenov Sergey N. 
Published: May 2021

AbstractAutocatalytic and oscillatory networks of organic reactions are important for designing life-inspired materials and for better understanding the emergence of life on Earth; however, the diversity of the chemistries of these reactions is limited. In this work, we present the thiol-assisted formation of guanidines, which has a mechanism analogous to that of native chemical ligation. Using this reaction, we designed autocatalytic and oscillatory reaction networks that form substituted guanidines from thiouronium salts. The thiouronium salt-based oscillator show good stability of oscillations within a broad range of experimental conditions. By using nitrile-containing starting materials, we constructed an oscillator where the concentration of a bicyclic derivative of dihydropyrimidine oscillates. Moreover, the mixed thioester and thiouronium salt-based oscillator show unique responsiveness to chemical cues. The reactions developed in this work expand our toolbox for designing out-of-equilibrium chemical systems and link autocatalytic and oscillatory chemistry to the synthesis of guanidinium derivatives and the products of their transformations including analogs of nucleobases.