bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Analysis in AdultC. elegansReveals State-Dependent Alteration of Neural and Behavioral Responses
Authors: Lawler Daniel E. , Chew Yee Lian , Hawk Josh D. , Aljobeh Ahmad , Schafer William R. , Albrecht Dirk R. 
Published: January 2021

Sleep, a state of quiescence associated with growth and restorative processes, is conserved across species. Invertebrates including the nematodeCaenorhabditis elegansexhibit sleep-like states during development, satiety, and stress. Here, we describe behavior and neural activity during sleep and awake states in adultC. eleganshermaphrodites using new microfluidic methods. We observed effects of fluid flow, oxygen, feeding, odors, and genetic perturbations on long-term sleep behavior over 12 h. We developed a closed-loop sleep detection system to automatically deliver chemical stimuli to assess sleep-dependent changes to evoked neural responses in individual animals. Sleep increased the arousal threshold to aversive stimulation, yet the associated sensory neuron and first-layer interneuron responses were unchanged. This localizes adult sleep-dependent neuromodulation within interneurons presynaptic to the premotor interneurons, rather than afferent sensory circuits. However, sleep prolonged responses in appetitive chemosensory neurons, suggesting that sleep modulates responsiveness specifically across sensory systems rather than broadly damping global circuit activity.SIGNIFICANCE STATEMENTMuch is known about molecular mechanisms that facilitate sleep control. However, it is unclear how these pathways modulate neural circuit-level sensory processing or how misregulation of neural activity contributes to sleep disorders. The nematodeCaenorhabditis elegansprovides the ability to study neural circuitry with single-neuron resolution, and recent studies examined sleep states between developmental stages and when stressed. Here, we examine an additional form of spontaneous sleep in adultC. elegansat the behavioral and neural activity levels. Using a closed-loop system, we show that delayed behavioral responses to aversive chemical stimulation during sleep arise from sleep-dependent sensorimotor modulation localized presynaptic to the premotor circuit, rather than early sensory circuits.
La imago mundi de Juan Bonilla
Authors: Gutiérrez Valencia Cristina 
Published: January 2021

La narrativa breve de Juan Bonilla muestra una concepción del género en el filo entre el realismo y el cuestionamiento de la realidad. La imagen del mundo representada en sus relatos refleja la sociedad posmoderna y del simulacro a través de las técnicas de la narrativa de la imagen: la copia, la imitación, la autoficción y metaficción y la intertextualidad se combinan con la tecnología de las pantalla, tematizando la televisión o los videojuegos para reflexionar sobre los nuevos modos de representación del mundo.
Palabras clave: Juan Bonilla, posmodernismo, simulacro, narrativa de la imagen, televisión
Revealing the nanoindentation response of a single cell using a 3D structural finite element model
Authors: Yang Wenjian , Lacroix Damien , Tan Lay Poh , Chen Jinju 
Published: January 2021

AbstractChanges in the apparent moduli of cells have been reported to correlate with cell abnormalities and disease. Indentation is commonly used to measure these moduli; however, there is evidence to suggest that the indentation protocol employed affects the measured moduli, which can affect our understanding of how physiological conditions regulate cell mechanics. Most studies treat the cell as a homogeneous material or a simple core–shell structure consisting of cytoplasm and a nucleus: both are far from the real structure of cells. To study indentation protocol-dependent cell mechanics, a finite element model of key intracellular components (cortex layer, cytoplasm, actin stress fibres, microtubules, and nucleus) has instead been developed. Results have shown that the apparent moduli obtained with conical indenters decreased with increasing cone angle; however, this change was less significant for spherical indenters of increasing radii. Furthermore, the interplay between indenter geometry and intracellular components has also been studied, which is useful for understanding structure-mechanics-function relationships of cells.
Controlling the high temperature deformation behavior and thermal stability of ultra-fine-grained W by re alloying
Authors: Kappacher Johann , Renk Oliver , Kiener Daniel , Clemens Helmut , Maier-Kiener Verena 
Published: January 2021

Abstract
Due to their outstanding properties, ultra-fine-grained tungsten and its alloys are promising candidates to be used in harsh environments, hence it is crucial to understand their high temperature behavior and underlying deformation mechanisms. Therefore, advanced nanoindentation techniques were applied to ultra-fine-grained tungsten–rhenium alloys up to 1073 K. A continuous hardness decrease up to 0.2 $$T_{\text{m}}$$

T
m

is rationalized by a still dominating effect of the Peierls stress. However, the absence of well-established effects of Rhenium alloying, resulting in a reduced temperature dependence of strength for coarse-grained microstructures, was interpreted as an indication for a diminishing role of kink-pair formation in ultra-fine-grained metals with sufficiently fine grain size. Despite slight grain growth in W, dislocation–grain boundary interaction was identified as the dominating deformation mechanism above 0.2 $$T_{\text{m}}$$

T
m

. Interaction and accommodation of lattice dislocations with grain boundaries was affected by a reduced boundary diffusivity through alloying with Re.

Graphic abstract
Magnesium-containing composition influencing morphological parameters and gelatinase B activity in endometrial tissues in experimental chronic endometrial inflammation
Authors: Rogova L. N. , Tikhaeva K. Yu. , Tkachenko L. V. , Shesternina N. V. , Povetkina V. N. , Staravoitov V. A. , Dyachkova S. Yu. 
Published: January 2021

Aim: to assess an effect of medicinal magnesium-containing composition on gelatinase B expression intensity and morphological parameters of chronic experimental endometrial inflammation.Materials and Methods. There were conducted experiments with 60 sexually mature female Wistar rats to determine an effect of medicinal magnesium-containing composition (contains magnesium chloride – a natural polymineral Bischofite) on gelatinase B activity in endometrial tissues (counting number of gelatinase-B-positive cells and intensity of gelatinase B expression), morphological parameters of cell infiltration, as well as amount of magnesium in red blood cell mass collected from the inferior vena cava and subclavian vein. All such parameters were assessed in experimental animals from 4 groups: group 1 – animals in baseline state, group 2 – control, group 3 – experimental chronic endometritis (CE), group 4 – experimental CE after treatment with medicinal magnesium-containing composition. Results. It was found that use of medicinal magnesium-containing composition increased amount of erythrocyte magnesium up to the baseline level and increased both number and expression intensity of stromal gelatinase B-positive cells. In addition, magnesium level in erythrocyte mass from the inferior vena cava was increased and accompanied with restored eosinophil-plasmacyte as well as significantly elevated macrophage-lymphocyte infiltration in endometrial tissues compared to CE animals lacking therapy. Conclusion. The results of this study allow us to conclude about importance of gelatinase B in pathogenesis of experimental chronic endometrial inflammation as well as an opportunity of regulating gelatinase B activity by applying medicinal magnesium containing drug in pathogenetic therapy of experimental CE.
Time Correction of Ocean-Bottom Seismometers Using Improved Ambient Noise Cross Correlation of Multicomponents and Dual-Frequency Bands
Authors: Tian Jinyu , Lin Jian , Zhang Fan , Xu Min , Zhang Yayun , Guo Laiyin , Zeng Xin 
Published: January 2021

Abstract
An effective approach was developed for identifying and correcting ocean-bottom seismometer (OBS) time errors through improving ambient noise cross-correlation function (NCCF) analysis and combination with other methods. Significant improvements were illustrated through analyzing data from a passive-source seismic experiment in the southwestern sub-basin of the South China Sea. A novel method was first developed that can effectively identify errors in the sampling frequency of the OBS instruments. The traditional NCCF method was then expanded by increasing the analyzed data spectrum from a single-frequency band to dual-frequency band pairs, thus doubling the number of available data points and substantially improving the time correction quality. For data with relatively low signal-to-noise ratios, the average time errors were reduced from the original average values of 60–80 ms by the conventional methods to &lt;40  ms using the improved approaches. The new multistep procedure developed in this study has general applicability to analysis of other OBS experiments. The demonstrated significant improvements in the data quality are critical for advancing seismic tomography and other modern marine geophysical studies that require high accuracy in the OBS data.
Informationen und Berichte
Authors: Mionskowski Alexander , Myczko Kazimiera , Wolting Monika 
Published: January 2021

„Nur eine Fußnote der Geschichte – bleibt? Gegenlesarten.“ Małkocin, 19.-21.11.2010
„Fremdsprachenunterricht – omnimedial?“ Internationale Tagung. Poznań, 25.-26.3.2011
„Sich-Erinnern ist gegen den Strom schwimmen ‒ Christa Wolf und ihr Werk“. Wissenschaftlicher Workshop am Zentrum für Deutschsprachige Gegenwartsliteratur und Medien an der Universität Zielona Góra, 16.-18.6.2011
THE CONCEPT OF MASLAHAH IN ISLAMIC FINANCIAL LITERACY AMONG YOUTH IN BANK NEGARA MALAYSIA MUSEUM ART AND GALLERY
Authors: Mahphoth Mohd Halim , Sulaiman Zuraidah 
Published: January 2021

The effort to enhance financial literacy has become extremely important and is complementary to the initiative by Consumer Credit Act in order to strengthen the credit consumer protection framework in Malaysia. Therefore, Bank Negara Malaysia Museum Art and Gallery (BNM MAG) educates the public through exhibits that foster visitors’ understanding of financial knowledge especially the Sharia compliant matters at their Islamic Finance Gallery. This study examined the relationships between satisfying experiences and generic learning outcomes of youth visitors at BNM MAG. The study examined three key satisfying experiences that had significant and positive effects on the generic learning outcomes of youth visitors including affective, cognitive and sensory experiences. However, social experiences were not significant towards generic learning outcomes on youth visitors. This study provides insights and drive efforts to promote effective delivery of financial education initiatives to Malaysians in a sustainable manner. The authors expect that policymakers or museum managers could make use of the findings to improve Malaysians’ financial literacy in general, thus helping Malaysians making informed financial decisions. The study contributes to the advancement of Islamic financial education for the youth with the purpose of improving creative and productive attitudes.Upaya meningkatkan literasi keuangan menjadi sangat krusial dan mendukung inisiasi Undang-Undang Kredit Konsumen untuk memperkuat kerangka perlindungan kredit konsumen di Malaysia. Maka, Bank Negara Malaysia Museum Art and Gallery (BNM MAG) mengedukasi masyarakat melalui pameran yang memberikan pemahaman kepada pengunjung tentang keuangan khususnya yang berhubungan dengan syariah di Islamic Finance Gallery (Galeri Keuangan Syariah). Studi ini mengkaji hubungan antara kepuasan pengalaman dan hasil pembelajaran umum (generic learning outcomes/GLO) yang dialami pengunjung muda di BNM-MAG. Ada acuan kepuasan pengalaman yang dijadikan objek studi yang memiliki efek signifikan dan positif terhadap GLO di kalangan pengunjung muda termasuk pengalaman afektif, kognitif, dan sensori. Meskipun begitu, pengalaman sosial para pengunjung tidak signifikan terhadap GLO. Studi ini memberi wawasan dan mengenalkan usaha untuk mengenalkan penyampaian yang efektif tentang inisiasi pendidikan keuangan pada warga Malaysia dengan cara yang berkelanjutan. Penulis berharap agar pembuat kebijakan atau pengolah museum dapat memanfaatkan temuan ini untuk meningkatkan literasi keuangan warga Malaysia secara umum, dengan demikian membantu mereka untuk membuat keputusan keuangan yang tepat. Penelitian ini memiliki kontribusi meningkatkan pendidikan keuangan Islam bagi para pemuda dengan tujuan menumbuhkan sikap kreatif dan produktif.
Factor of combined pathology in geriatric patients with prostate adenoma
Authors: Leshchenko I. G. , Akimov A. I. 
Published: January 2021

Samara Regional Clinical Hospital of War Veterans in the period from 2000 to 2015 examined and treated 639 elderly and senile patients with prostate adenoma, who underwent an isolated adenomectomy, transurethral prostate resection, or simultaneous surgery. Among them, 191 (29.9%) patients underwent simultanous surgery. The paper presents the nature and frequency of dominant concomitant diseases in geriatric patients with prostate adenoma in the first (2000-2006) and second (2007-2015) periods of the study. Application in the second period of the author's therapeutic and diagnostic developments, taking into account concomitant pathology, significantly affected the reduction of a number of severe intra- and postoperative complications and lethality in comparison with the first period.
ANALISIS TINDAK TUTUR BERBASIS KORPUS PADA TAGAR TOLAK OMNIBUS LAW
Authors: Puspitasari Devi Ambarwati , Okitasari Indah 
Published: January 2021

ABSTRACT
The purpose of this study is to find out the discursive portrayal of the hashtag “tolakomnibuslaw” on Twitter, which reveals rejection of the Job Creation Law by applying the synergy of linguistic corpus method and illocutionary speech act analysis. The data of this research is a corpus based taken from the utterances of Twitter users who use the hashtag of Omnibus Law Rejection (#tolakomnibuslaw) on October 8, 2020. Word lists and collocations analysis are utilized to see patterns of the hashtag used by people in expressing rejection of the Job Creation Law. Concordance is used to lean more the analysis of speech acts and study the data. The result show that there are 38 styles of the hashtag use. Most of them is the use of noun behind the hashtag “tolakomnibuslaw”. In addition, there are also five common topic hashtags included the hashtag “tolakomnibuslaw”. From the perspective of speech acts, there are five types of speech acts that appear and are dominated by assertive speech and forms of criticism against government effort.
Keywords: linguistic corpus; social media; speech acts
Quantifying the Effects of Hip Surgery on the Sphericity of the Femoral Head in Patients with Mucopolysaccharidosis Type I
Authors: van der Veer Eline L. , Gielis Willem Paul , Weinans Harry , Beek Erik J. , van Hasselt Peter M. , Sakkers Ralph J.B. 
Published: January 2021

Background:
The introduction of stem cell transplantation has improved life expectancy and cognitive outcome in patients with mucopolysaccharidosis I, but this condition remains associated with substantial residual disease in several parts of the body. Many patients have hip dysplasia with progressive medial flattening of the femoral head. Quantitative evidence on the effect of surgery on remodeling to sphericity of flattened femoral heads is lacking. In the present study, we used statistical shape modeling to quantify the effect of hip surgery on the sphericity of the femoral head in patients with mucopolysaccharidosis I.

Methods:
We performed a retrospective case control study involving a series of 23 patients with hip dysplasia due to mucopolysaccharidosis I. Surgery was not offered to the first 11 children (control group). Following a change in treatment protocol, the next 12 children underwent bilateral proximal femoral varus derotation osteotomy and Pemberton osteotomy for the treatment of acetabular dysplasia with progressive femoral head flattening (surgery group). The surgery and control groups were compared with a reference group of patients with normal hips. Statistical shape modeling was used to quantify the shape of the femoral head (i.e., flattening and/or roundness of the epiphysis).

Results:
The mean age at the time of stem cell transplantation in the surgery and control groups was comparable (1.2 years). The mean age at the time of surgical intervention was 5.5 years, and mean duration of postoperative follow-up was 3.3 years. Statistical shape modeling showed variations within the total group in terms of medial indentation, width, height, and sphericity of the femoral heads. In contrast to the progressive femoral head flattening in the control group, the surgery group showed improvement of the sphericity of the femoral head after surgery. The overall shape characteristics of the femoral head in the surgery group were similar to those of the reference group of patients with normal hips.

Conclusions:
To our knowledge, this is the first study in patients with mucopolysaccharidosis I that has shown quantitative remodeling of the dysplastic, flattened femoral head to normal sphericity after increasing containment of the femoral head.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Lifetime Risk of Revision Hip Replacement Surgery in Australia Remains Low
Authors: Ackerman Ilana N. , Busija Ljoudmila , Lorimer Michelle , de Steiger Richard , Graves Stephen E. 
Published: January 2021

Background:
Well-validated data from arthroplasty registries provide an opportunity to understand contemporary use of revision hip replacement at a national level. Such information can underpin health-care resource allocation and surgical workforce planning. The purposes of the present study were to describe the demographic characteristics of patients managed with revision hip replacement surgery in Australia and to examine changes in the lifetime risk of revision hip replacement over a decade.

Methods:
Deidentified individual-level data on all revision hip replacement procedures performed in Australia from 2007 to 2017 were obtained from the Australian Orthopaedic Association National Joint Replacement Registry. Life tables and population data were sourced from the Australian Bureau of Statistics. The lifetime risk of revision surgery each year was estimated with use of a standardized approach, with separate calculations for males and females.

Results:
A total of 46,086 revision hip replacement procedures were performed from 2007 to 2017. The median age at the time of surgery was 72 years (interquartile range, 63 to 80 years). While loosening or lysis became less frequent reasons for revision over time (from 51% in 2007 to 28% in 2017), revision hip replacement for infection became increasingly common (from 14% in 2007 to 25% in 2017). Revisions for metal-related pathology peaked in 2011. Utilization rates were highest for males ≥80 years of age (127.9 procedures per 100,000 population in 2017). Although a small rise was evident in 2011 and 2012 (to 2.39% and 2.22%, respectively), the lifetime risk of revision hip replacement in females decreased from 1.90% (95% confidence interval [CI], 1.82% to 1.99%) in 2007 to 1.74% (95% CI, 1.66% to 1.82%) in 2017. A similar pattern was evident for males; the lifetime risk was 1.78% (95% CI, 1.69% to 1.86%) in 2007 and 1.57% (95% CI, 1.49% to 1.65%) in 2017.

Conclusions:
These data enable us to understand the epidemiology of revision hip replacement in Australia, including the shifting clinical indications for this procedure. At a population level, the lifetime risk of revision hip replacement remains low at <1 in 50 people in 2017. These methods can be utilized for population-level surveillance of revision burden and to enable between-country benchmarking.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Opioid Use Following Inpatient Versus Outpatient Total Joint Arthroplasty
Authors: Varady Nathan H. , Smith Eric L. , Clarkson Samuel J. , Niu Ruijia , Freccero David M. , Chen Antonia F. 
Published: January 2021

Background:
Although the risks of continued opioid use following inpatient total joint arthroplasty (TJA) have been well-studied, these risks in the outpatient setting are not well known. The purpose of the present study was to characterize opioid use following outpatient compared with inpatient TJA.

Methods:
In this retrospective cohort study, opioid-naïve patients who underwent inpatient or outpatient (no overnight stay) primary, elective TJA from 2007 to 2017 were identified within a large national commercial-claims insurance database. For inclusion in the study, patients had to have been continuously enrolled in the database for ≥12 months prior to and ≥6 months after the TJA procedure. Multivariable analyses controlling for demographics, geography, procedure, year, and comorbidities were utilized to determine the association between surgical setting and risk of persistent opioid use, defined as the patient still filling new opioid prescriptions >90 days postoperatively.

Results:
We identified a total of 92,506 opioid-naïve TJA patients, of whom 57,183 (61.8%) underwent total knee arthroplasty (TKA). Overall, 7,342 patients (7.9%) underwent an outpatient TJA procedure, including 4,194 outpatient TKAs. Outpatient TJA was associated with reduced surgical opioid prescribing (78.9% compared with 87.6% for inpatient procedures; p < 0.001). Among the 80,393 patients (86.9%) who received surgical opioids, the total amount of opioids prescribed (in morphine milligram equivalents) was similar between inpatient (median, 750; interquartile range, 450 to 1,200) and outpatient procedures (median, 750; interquartile range, 450 to 1,140; p = 0.47); however, inpatient TJA patients were significantly more likely to still be taking opioids after 90 days postoperatively (11.4% compared with 9.0% for outpatient procedures; p < 0.001). These results persisted in adjusted analysis (adjusted odds ratio, 1.13; 95% confidence interval, 1.03 to 1.24; p = 0.01).

Conclusions:
Outpatient TJA patients who received opioid prescriptions were prescribed a similar amount of opioids as those undergoing inpatient TJA procedures, but were significantly less likely to become persistent opioid users, even when controlling for patient factors. Outpatient TJA, as compared with inpatient TJA, does not appear to be a risk factor for new opioid dependence, and these findings support the continued transition to the outpatient-TJA model for lower-risk patients.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Tarsal Coalition of the Cuneiforms in a Young Athlete
Authors: Johnson Alexander J. , Gokcen Eric 
Published: January 2021

Case:
Tarsal coalitions are relatively common, but there are no reports of cuneiform-to cuneiform coalition in the English language literature. The authors present a case of medial-to-intermediate cuneiform coalition in a young female track athlete. Previous nonoperative treatments had been unsuccessful. Coalition release and medial-intermediate cuneiform arthrodesis enabled her to return initially to full athletic participation without pain, but she had return of pain that persists despite removal of hardware.

Conclusion:
Medial-intermediate cuneiform coalition is rare. Surgery in this patient provided a short period of pain-free athletic participation, but long-term outcomes are not proven, and further research is needed.