bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drilling the Point Pleasant-Utica Shale Fractured Formation During the COVID-19 Pandemic Utilizing CBHP MPD with a PMCD Contingency
Authors: Nauduri Sagar , Shimi Ahmed , Guefack Gildas , Parker Martyn 
Published: September 2021

Abstract
Drilling the Point Pleasant-Utica formation in the Appalachian Basin has posed challenges to most operators, especially in Western Pennsylvania. A recent well drilled in this region demonstrated that with proper buy-in from the Operator, Constant Bottomhole Pressure (CBHP) Managed Pressure Drilling (MPD) could be the answer when planned and executed correctly. This paper drives the point that MPD is more than simply dropping chokes on location.
Prior to drilling the well, the Operator initiated the communication very early with the MPD service provider and created an avenue to reduce the projected mud weight and develop a detailed CBHP MPD plan with a Pressurized Mudcap Drilling (PMCD) contingency. The anticipated challenges on this well were: High-pressure gas fractures, formation instability/shale breakout, severe/total loss of returns, inability to reach Target Depth, and casing/cementing issues.
The Operator took time and worked with the new MPD service provider to carefully design and plan a new well (referred to as ‘Y1’ in this document), which helped execute the MPD part of the project within 30 days. In contrast, the MPD execution on a previous well (referred to as ‘X2’ in this document) with the older MPD service provider took more than 90 days. MPD execution on the new MPD well included dynamic influx management and loss mitigation, and understanding of the petro-physical conditions to reach the target. The significant factors that helped drill this well safely with a low Non-Productive Time (NPT) are excellent safety culture, communication, high quality and well-maintained MPD equipment, and a very knowledgeable and highly experienced MPD team. This project was finished within half of the budgeted Authorization for Expenditure (AFE), setting milestones in this region for this Operator.
Determining Diagnosis Date of Diabetes Using Structured Electronic Health Record (EHR) Data: The SEARCH for Diabetes in Youth Study
Authors: Lenoir Kristin M , Wagenknecht Lynne E , Divers Jasmin , Casanova Ramon , Dabelea Dana , Saydah Sharon , Pihoker Catherine , Liese Angela D , Standiford Debra , Hamman Richard , Wells Brian J 
Published: September 2021

Abstract
Background. Disease surveillance of diabetes among youth has relied mainly upon manual chart review. However, increasingly available structured electronic health record (EHR) data have been shown to yield accurate determinations of diabetes status and type. Validated algorithms to determine date of diabetes diagnosis are lacking. The objective of this work is to validate two EHR-based algorithms to determine date of diagnosis of diabetes.Methods. A rule-based ICD-10 algorithm identified youth with diabetes from structured EHR data over the period of 2009 through 2017 within three children’s hospitals that participate in the SEARCH for Diabetes in Youth Study: Cincinnati Children’s Hospital, Cincinnati, OH, Seattle Children’s Hospital, Seattle, WA, and Children’s Hospital Colorado, Denver, CO. Previous research and a multidisciplinary team informed the creation of two algorithms based upon structured EHR data to determine date of diagnosis among diabetes cases. An ICD-code algorithm was defined by the year of occurrence of second ICD-9 or ICD-10 diabetes code. A multiple-criteria algorithm consisted of the year of first occurrence of any of the following: diabetes-related ICD code, elevated glucose, elevated HbA1c, or diabetes medication. We assessed algorithm performance by percent agreement with a gold standard date of diagnosis determined by chart review. Results. Among 3777 cases, both algorithms demonstrated high agreement with true diagnosis year and differed in classification (p=0.006): 86.5% agreement for the ICD code algorithm and 85.9% agreement for the multiple-criteria algorithm. Agreement was high for both type 1 and type 2 cases for the ICD code algorithm. Performance improved over time. Conclusions. Year of occurrence of the second ICD diabetes-related code in the EHR yields an accurate diagnosis date within these pediatric hospital systems. This may lead to increased efficiency and sustainability of surveillance methods for incidence of diabetes among youth.
Understanding the Influence of Climate Elements on Traffic Behavior: The Wind Impact Approach
Authors: Sentić Ivana , Đorđević Jasmina , Đorđević Tijana , Ljubojević Mirjana , Čukanović Jelena 
Published: September 2021

Abstract
Due to intense highway congestion in Europe, increased percentage of highway accidents, as well as mortality rate, safety is an imperative in highway planning and design. Highway design safety standards have been researched extensively, but not enough attention has been paid to the surrounding environmental impacts, foremost climate elements. Therefore, this research attempts to understand the least researched climate element — the wind, and its impact on highway safety. The highway landscape falls under the category of the wind impacts that can cause significant problems for the drivers throughout the year. The values for wind direction, frequency and intensity were taken from the CARPATCLIM database. The evaluation of homogenized and harmonized set of data on a daily basis for a twenty-year period documented a variety of wind impacts on highway safety. It was found that the wind is constantly present throughout the year, with specific monthly oscillations. By using the ArcGis and the interpolation method, it has been clearly observed at which points the effect of intense winds was present the most. In order to understand the overall image of highway safety, fieldwork was conducted in various meteorological conditions. The checklists photo-documented and qualitatively described the observed extreme wind events (alone or combined with one more climate element). Based on everything described above, the image of the current situation was provided, and the proposal for control of the impact of wind using an adequate vegetation assembly (windbreaks) has been offered.
Fabrication and optimization of bio-silver nanoparticles: Activity evaluation against beta-lactamases-resistant Enterococcus faecalis
Authors: Fattah Bikhal , Arif Huner , Mousa Haider 
Published: September 2021

Abstract
Objectives: Due to the presence of antibiotic-resistant genes, treatment options of clinical isolates are exceedingly limited. This study was aimed to fabricate, optimize, characterize, and evaluate the action of silver nanoparticles (AgNPs) against a clinical isolate of Enterococcus faecalis.Materials and Methods: A combination of cell-free supernatant (C-FS) of the filamentous fungus Fusarium solani and Gram-negative Comamonas aquatica for AgNPs formation was proposed; the antigrowth and antibiofilm of AgNPs against E. faecalis harboring blaTEM and blaCTX-M genes were assessed. Results: The ratio of 1:2 v/v (C-FS:AgNO3) at pH 9.0 for 72 h in 1 mM AgNO3 were the optimal conditions for AgNPs formation. UV-vis absorption peak appeared at 425 nm and the crystalline nature of synthesized particles was verified by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FTIR) analysis confirmed the interaction of protein molecules with the AgNPs. Transmission electron microscopy (TEM) analysis demonstrated that fabricated AgNPs were relatively monodispersed, approximately spherical, and of size 2-7.5 nm. blaTEM and blaCTX-M were detected in E. faecalis; the growth and biofilm of E. faecalis were significantly decreased by the action of 12.5 µg/ml AgNPs. Conclusions: This is the first study proposing alternative sources to form AgNPs via synergistic metabolites of F. solani and C. aquatica. The results here offer a foundation for developing an effective therapy using AgNPs against clinical pathogens.
Factors Impinge on Development of a Smart City: A Field Study
Authors: Jothimani Priya , Chenniappan Palanisamy , Chidambaranathan Vinothini 
Published: September 2021

Abstract
Smart City aims at amassed connectivity at various levels in the midst of citizens, as well as amid the administration and the daily growing population. India is one of the developing country where population growth is one of the significant area is to be noted seriously. A city is a large and permanent human environment that provides its citizens with many services and opportunities. The rapid economic growth and population growth have put a huge amount of strain on urban infrastructure and service provision. India is an under developing nation to modernize urban life, the current urbanization needs good tactics and creative planning. India’s government has launched 100 Smart Cities where it is expected that citizens will use new innovations and resolve the issues. Smart Cities are intended for finest usage of space and resources along with an effectual and optimum dissemination of benefits. This study is to investigate and analysis of Chennai Smart city Mission (SCM) development. This work has been undertaken to learn about the aspects of Smart Development and the factors that governing Smart City. The analysis has been split up into 4 portions as Questionaries’ survey in the Chennai city, Frequency and Percentage analysis, Descriptive analysis and using Structural equation modelling (SCM). Using the SPSS (Statistical Package for Social Sciences) version 21.0, conversational interviewing, and questionnaire survey and also journal study are conducted to find factors influencing the implementation of smart city and reviewed. Using the SEM (structural equation model) AMOS 21.0 software, confirmatory factor assessment had done. This study gives in-depth knowledge in implementation of the smart city scheme aspects and also suggests solution for most affecting factor in a city.
Chromatin Enrichment for Proteomics in Plants (ChEP-P) Implicates the Histone Reader ALFIN-LIKE 6 in Jasmonate Signalling
Authors: Vélez-Bermúdez Isabel Cristina , Schmidt Wolfgang 
Published: September 2021

Abstract
BackgroundCovalent modifications of core histonesgoverndownstream DNA-templated processes such as transcription by altering chromatin structure and function. Previously, we reported that the plant homeodomain protein ALFIN-LIKE6 (AL6), a bona fide histone reader that preferentially binds trimethylated lysin 4 on histone 3 (H3K4me3), is critical for recalibration of cellular phosphate (Pi) homeostasis and root hair elongation under Pi-deficient conditions. ResultsHere, we demonstrate that AL6 is also involved in the response of Arabidopsis seedlings to jasmonic acid (JA) during skotomorphogenesis, possibly by modulating chromatin dynamics that affect the transcriptional regulation of JA-responsivegenes. Dark-grown al6 seedlings showed a compromised reduction in hypocotyl elongation upon exogenously supplied JA, a response that was calibrated by the availability of Pi in the growth medium. A comparison of protein profiles between wild-type and al6 mutant seedlings using a quantitative Chromatin Enrichment for Proteomics (ChEP) approach,that we modified for plant tissue and designated ChEP-P (ChEP in Plants), yielded a comprehensive suite of chromatin-associated proteins and candidates that may be causative for the mutant phenotype. ConclusionsAltered abundance of proteins involved in chromatin organization in al6 seedlings suggests a role of AL6 in coordinating the deposition of histone variants upon perception of internal or environmental stimuli. Our study shows that ChEP-P is well suited to gain holistic insights into chromatin-related processes in plants. Data are available via ProteomeXchange with identifier PXD026541.
A theory of viscoelastic crack growth-Revisited (Revised)
Authors: Schapery Richard A 
Published: September 2021

Abstract
A theory of viscoelastic crack growth developed nearly five decades ago is generalized to express traction in the so-called fracture process zone or failure zone as a function of the crack opening displacement (COD). In earlier work, except for minor exceptions, traction was specified as a function of location. The new model leads to a nonlinear double integral that has to be solved for the COD before crack growth can be predicted. First, a closed-form, accurate approximation is found for a linear elastic body. We then show that this COD may be easily and accurately extended to linear viscoelasticity using a realistic, broad spectrum creep compliance. An analytical relationship connecting the stress intensity factor to crack speed then follows. Consistent with earlier work, it is defined almost entirely by the creep compliance. Five different failure zone tractions are employed; their differences are shown to have little effect on crack growth other than through a speed shift factor. The Appendix discusses initiation of growth.
An Ion-Imprinted Imidazole-Functionalized Ordered Mesoporous Silica For Selective Removal of Chromium(VI) From Electroplating Effluents
Authors: Cen Shuibin , Yang Lan , Li Ruimin , Gong Shengzhao , Tan Jiean , Zeng Lixi 
Published: September 2021

Abstract
In this work, ion imprinted technology incorporated with mesoporous silica materials (MCM-41) to obtain the novel specific adsorbent, ion imprinted mesoporous silica. Cr(VI) imprinted mesoporous silica (Cr(VI)IMS) was synthesized and used for adsorption studies and waste water application. A synthesized imidazolyl silane agent act as the functional monomer in the imprinted process to build up highly ordered functionalized imprinted materials. The chemical composition, thermal stability, porosity and highly ordered morphology were characterized by Fourier transform infrared spectroscopy (FTIR), solid state nuclear magnetic resonance(NMR), Brunauer-Emmett-Teller (BET) method, X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) respectively. The Brunauer-Emmett-Teller (BET) surface area was 1054.51 m2 g-1 in this study. The Cr(VI)IMS showed great adsorption capacity to hexavalent chromium ions in acidic solution up to 45.6 mg g-1. Cr(VI)IMS displayed much higher adsorption capacity to Cr(VI) ions than other negative ions. The relative selectivity coefficient was 2.56, higher than those of other anions (below 1.5). After eight adsorption-regeneration cycles, the adsorption efficiency of Cr(VI)IMS still reached 92.5%. The Cr(VI)IMS was found to exhibit equivalent property after multiple cycles of experiments, indicating good repeatability and reproducibility.
Comparing Two Equations for Estimation of Kidney Function (Cockcroft-gault and Glomerular Filtration Rate Assessment in Liver Disease) for Vancomycin Dosing in Adult Liver Transplant Recipients: a Pilot, Randomized Clinical Trial
Authors: Saee Yasaman , Dashti-Khavidaki Simin , Ahmadinejad Zahra , Ghiasvand Fereshteh 
Published: September 2021

Abstract
Background: In the setting of impaired liver function, estimation of glomerular filtration rate (GFR) using common creatinine based equations is inaccurate. Recently, Glomerular Filtration Rate Assessment in Liver Disease (GRAIL) model has been introduced for estimating GFR in liver transplantation. This study was conducted to compare vancomycin dose adjustment in liver transplant patients using Cockcroft-Gault (C-G) versus GRAIL method.Methods: In this pilot, randomized clinical trial, adult liver transplant recipients who were candidate to receive intravenous vancomycin were enrolled. GFR and creatinine clearance were estimated using GRAIL model and C-G equation in the intervention and control arms, respectively and vancomycin maintenance doses were adjusted accordingly. At the steady state , peak and trough serum concentrations of vancomycin were collected for pharmacokinetic comparisons.Results: Fifteen patients were enrolled in each arm of the study. Mean daily dose of vancomycin was estimated insignificantly lower for individuals in GRAIL arm than C-G group (1500.00±544.45 versus 1750.00± 389.60mg). The rate of patients who achieved the target vancomycin trough concentration was similar between the two study arms (20%). Compared with C-G group, higher rate of patients in GRAIL arm experienced below-target vancomycin trough concentrations (40% versus 13.3%) and lower rate showed above target trough concentration (40% versus 66.7%), although these differences did not reach statistical significance. Higher rates of patients with at target and above target vancomycin AUC/MIC were seen in the C-G group compared with GRAIL group (40% versus 26.7% and 53.3% versus 26.7%, respectively), while individuals in the GRAIL arm represented significantly higher rate of below target vancomycin AUC/MIC than C-G arm (46.7% versus 6.7%) (P=0.049). No differences in clinical outcomes were observed between the two groups.Conclusion: Using GRAIL model for vancomycin dose selection may result in less percent of patients with at target AUC/MIC exposure compared to C-G method and expose more percent of patients at risk of vancomycin under dosing.
Cadaveric Study of the Mode of Termination of the Sciatic Nerve in a Malian Population: Cases of Trifurcation and Hexafurcation
Authors: Touré Tata , Ba Babou , Moussa Adoul Kader , Kanté Abdoulaye , Traoré Falé , Yatera Demba , Dicko Moustapha , Essomba Laurent Désiré Ndzie , Coulibaly Tieman , Ongoïba Nouhoum 
Published: September 2021

Abstract
Background: The sciatic nerve is the largest nerve in body. It is the only terminal branch of the sacral plexus. It emerges under the piriformis muscle, descends into the gluteal region, then into the posterior compartment of the thigh. It ends in the popliteal fossa by dividing into the tibial and common peroneal nerve. It is the most frequently injured nerve. The aim of this work was to study the mode of termination of the sciatic nerve by cadaveric dissection in a Malian population.Materials and methods: This was a cross-sectional study, carried out at the anatomy laboratory of the Faculty of Medicine and Odontostomatology of Bamako, ranging from December 2019 to April 2021. The sciatic nerve was dissected 74 times in 37 cadaveric subjects (29 men and 8 women).Results: The classic termination mode (the sciatic nerve terminates giving the tibial nerve and common peroneal nerve) was most frequently encountered with a prevalence of 82.43%. Anatomical variations were noted in 17.57%. Among these variations, trifurcation (termination in three branches) of the sciatic nerve was observed in 16.22%. Hexafurcation (six-branch termination) of the sciatic nerve was observed in 1.35%. The termination mode showed a significant difference being more frequently bilateral than unilateral (P˂0.05)Conclusion: Anatomical variations in the mode of termination of the sciatic nerve are not uncommon. The most common of these variations is the trifurcation in which the sciatic nerve ends up giving the tibial nerve, the common peroneal nerve and a third branch which is variable. Knowledge of these variations is important for surgeons when treating popliteal artery aneurysm, popliteal vessel fistula and popliteal fossa cysts.
Biomethane Potential Test To Access The Feasibility of Vegetable And Fruit Waste For Methane Yield Using Different Inoculums To Substrate Ratios
Authors: Agrawal Akanksha , Chaudhari Parmesh Kumar , Ghosh Prabir 
Published: September 2021

Abstract
To address the world's energy issue and global climate change, a green, efficient and carbon-neutral renewable energy sourcesare in great demand to replace fossil fuels. The study was undertaken to determine optimal inoculum to substrate ratio for increase in biogas generation via co-digestion of fruit and vegetable waste under mesophilic environmental conditions (25–34oC). Biomethane potential of the fruit and vegetable waste was accessed in terms of biogas yield. Digestate from gobar gas plant was taken as inoculum. Biomethane potential (BMP) assay was performed in a 500ml glass bottle with suitable inlet and outlet arrangement for taking feed and collection of biogas. Inoculum to substrateratio chosen for the study was 0.2, 0.3,0.5,0.7 and 0.8. Highest daily biogas yield was obtained for inoculum to substrate ratio of 30: 70 i.e. reactor R2 which is equivalent to 440 ml on day 14 with methane yield of 58%. Cumulative biogas yields for different inoculum to substrate ratio were in the range of 6–11.378 L/day.
Does the Prevalence of Anatomical Variants of the Brain Ventricles vary according to Socioeconomic Status? A Cross-sectional Imaging Survey in 2 Brazilian Private Hospitals
Authors: Martins Lia Pontes Lisboa , Sales Paulo Marcelo Gondim , Gomes Adriana de Menezes , Silva Marlon Sousa , Bezerra Gabriela de Andrade Meireles , Gondim Francisco de Assis Aquino 
Published: September 2021

Abstract
Background: Anatomical variants of brain ventricles are a known marker for abnormal central nervous system development. They seem to be more prevalent in several neuropsychiatric disorders, e.g. schizophrenia, personality disorders, and psychosis. However, knowledge about the risk factors and their overall prevalence in the general population, especially in developing countries is still limited. Methods: We evaluated the prevalence of prevalence of anatomical ventricular variants [Cavum septum pellucidum (CSP), Cavum vergae (CV), and Cavum velum interpositi (CVI)] in 1467 multislice head CTs from two large private hospitals in the city of Fortaleza, Ceará – Brazil. Results: Hospital one had a higher percentage of patients with low-cost health insurance, strokes, and neurocysticercosis (P<0.05). 15.1% of participants in hospital one versus 7.1% in hospital two had at least one type of cerebral cavum, including vestigial CSP. The rarest types of cava (CV and CVI) were twice more common in hospital one (P<0.05). Logistic regression analysis confirmed that patients from hospital one, older patients, and men were more likely to have any type of cerebral cavum and CSP. Conclusions: Anatomical brain ventricular variants (including vestigial CSP) were present in about 12% of participants of this middle-class Brazilian sample while also being more prevalent in male elderly and participants from lower socioeconomic strata. Further studies are necessary to prospectively investigate the association between socioeconomic variables and how they relate to the prevalence of anatomical brain ventricular variants and other known risk factors for developmental disorders.Trial registration: This study was approved by the Institutional Review Board from both participants institutions- Research Ethics Committee (CEP) - Unichristus (Protocols 099/11 and CAAE: 58763716.3.0000.5049).
Factors Associated With The Mental Health of Back-To-Wuhan College Students Based On Quantile Regression Model During The COVID-19 Period
Authors: Wu Qian , Zhuo Lijun , Li Hao , Zheng Ling , Ma Guoqing , Tao Hongbing 
Published: September 2021

Abstract
Background

The COVID-19 pandemic has been spreading rapidly in China and other countries since December 2019, which has increased the risk of infection, and brought the unbearable huge psychological pressure on people.
Methods

A cross-sectional questionnaire survey was conducted from 31 August 2020, to 14 September 2020 by convenience sampling on the back-to-Wuhan college students, which included the Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9), the Insomnia Severity Index-7 (ISI-7), and the revised Impact of Event Scale (IES-R) scales and the basic demographic characteristics.
Results

The results from 1017 participants suggested that 44%, 47.5%, 37.7%, 57.7% were the prevalence rates of the anxiety, depression, insomnia, and distress respectively. Moreover, quantile regression analysis was used to identify the factors related to the mental health variables of the back-to-Wuhan college students during the COVID-19 period.
Conclusion

The finding showed that the respondents who were near graduation, discriminated owing to the experience in Wuhan, and worried about the future trend of COVID-19 had a higher risk of becoming negative psychologic status, especially the bottom and median quantile, and might require more psycho-social interventions or support.