bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conhecimentos científicos, conhecimentos locais e hibridismo
Authors: Silveira Pedro Castelo Branco 
Published: March 2021

O artigo explora as paisagens construídas por um grupo acadêmico de pesquisa e por habitantes da área que foi o recorte espacial escolhido por este grupo, uma região rural do município de São Luiz do Paraitinga, São Paulo, Brasil. O objetivo é relacionar as paisagens tomando por base que grupos portadores de ontologias parcialmente distintas são capazes de ter bases comuns de comunicação. Recorre-se à ideia de que em certas circunstâncias são possíveis consensos pragmáticos sobre os efeitos das ações sobre o mundo e parte-se de uma noção de ontologia como uma lista do que existe. O caso estudado é útil para pensar em medida os conhecimentos científicos e os conhecimentos locais são de natureza menos diversa do que aparentam, sendo as diferenças principais o modo purificado como o conhecimento científico se apresenta e as redes sociais que os envolvem. Procura-se propor uma definição alternativa de senso comum, despida de um caráter pejorativo, que signifique o compartilhamento experiências, práticas e sentidos dados a práticas.
vida “no veneno” nas histórias sobre mortes
Authors: Vieira Danielli 
Published: March 2021

Neste trabalho são apresentadas as principais discussões realizadas na dissertação de mestrado da autora. Tal dissertação consistiu em uma análise de narrativas sobre homicídios que envolveram jovens em Santa Catarina. Os interlocutores da pesquisa eram jovens que se encontravam em regime de “privação de liberdade” (internação) para o cumprimento de medidas socioeducativas. No tocante a perspectiva teórica, focou-se a dimensão vivencial das situações nomeadas como “violências”, de maneira a pensar os homicídios praticados entre jovens a partir dos sujeitos sociais que emergem nas narrativas. Os interlocutores descreveram alguns casos de homicídios como “justificáveis”, passíveis de explicação e outros como “sem motivos”. Nas histórias sobre mortes, eles falaram também sobre suas próprias vidas no contexto do tráfico de drogas: a nada fácil “vida fácil”, os altos e baixos, o risco constante, a relação com a morte, as situações em que “é matar pra não morrer”.
From academic heritage to Aboriginal priorities
Authors: Glowczewski Barbara 
Published: March 2021

Throughout my 34 years of involvement with aboriginal people across australia, I have regularly chosen to respond to aboriginal priorities against a certain academic heritage, illustrated by the refusal of some colleagues – in France or Australia – to recognise the importance of women’s agency in the society, the impact of history on aboriginal ritual life and cosmology, the continuity of their culture in new forms of creativity, the respect of ethical protocols, the discrimination and social injustice suffered by indigenous people and the legitimacy of their political struggles.
Geochronology, Petrogenesis and Oxidation State of the Northparkes Igneous Suite, New South Wales, Australia: Implications for Magma Fertility
Authors: Hao Hongda , Campbell Ian H. , Cooke David R. , Nakamura Eizo , Sakaguchi Chie 
Published: March 2021

Abstract
New geochronological and geochemical data for the barren and ore-associated suites from the Northparkes porphyry Cu-Au deposits, Australia, have implications for magma fertility. The Goonumbla and Wombin Volcanics and intrusions are barren in the Northparkes area. A sample from Wombin suite yielded a zircon U-Pb age of 433.8 ± 3.1 Ma, whereas the ore-associated porphyries yielded ages between 441.8 ± 3.7 and 436.3 ± 4.5 Ma. The bulk of the mineralization at Northparkes is associated with a K-feldspar-phyric quartz monzonite porphyry (K-QMP), which gave U-Pb zircon ages of 441.8 ± 3.7 and 441.1 ± 2.5 Ma. Whole-rock Sr-Nd isotope compositions of the Goonumbla, Wombin, and ore-associated suites are similar, with (87Sr/86Sr)i = 0.704112 to 0.704424 and εNd = 5.6 to 6.9, which is typical of primitive intraoceanic island arcs, and their Pb isotope values lie within the MORB array. Most of the zircons from the Wombin and ore-associated suites have arc mantle-like O-Hf isotope compositions, with δ18O values that vary from 6.13 to 4.95, and εHf(t) from 11.5 to 6. These results suggest that the Goonumbla, Wombin, and ore-associated suites originated from typical arc mantle. The magmas that produced the Goonumbla and Wombin suites were dominated by plagioclase-pyroxene fractionation, and the Wombin suite has a low oxidation state with ΔFMQ between ~0 and 1.5. They were relatively reduced and dry. This combination resulted in early sulfide saturation, probably without reaching fluid saturation. Trace element modeling shows that plagioclase-amphibole dominated the later stages of fractionation of the ore-associated suite, implying that it had a higher water content than the barren suites. It was also more oxidized (ΔFMQ from ~0 to 4). The result was late sulfide saturation, which was followed shortly thereafter by voluminous fluid release. As a consequence, the ore-forming fluid effectively transferred Cu and Au from the magma to the site of hydrothermal ore deposition. We suggest that the higher water content and oxidation state of the ore-associated suite was due to the deep underlying magma chamber, which was recharged by many more pulses of magma than the chamber that underlay the barren suites. This is more effective in raising the concentration of incompatible water and ferric iron in the residual melt than straight fractional crystallization. High oxygen fugacities and water contents played a significant role in determining the timing of sulfide and fluid saturation, respectively, and as a result, they had a critical influence on magma fertility.
Emerging Stereotypes about the Target Culture through Popular Culture and Cultural Heritage References in EFL Textbooks
Authors: Cifone Ponte María Daniela , Alonso Andrés Canga 
Published: March 2021

EFL textbooks are not only grammar references but also a tool through which learners get their first glimpses to the target culture. Thus, their content should be carefully selected to avoid providing the learners with a conventionalized view of the target society which is likely to contribute to create cultural stereotypes. This paper analyzes references to the target culture through the examination of two cultural categories: Popular Culture and Cultural Heritage in five 2nd Baccalaureate EFL textbooks used in La Rioja, Spain. The main purpose of the present study is to explore (i) the status of the target culture over other cultures in these materials and, (ii) the gender, nationality and ethnic stereotypes that may emerge from their content. Results evince that the target culture is predominant in EFL textbooks used by 2nd Baccalaureate students and stereotypes related to gender, ethnicity and nationalities are strongly present in their content.
De schadepost huishoudelijke hulp: op zoek naar handvatten ter invulling van het ‘normaal en gebruikelijk’-criterium
Authors: Janssen M.W.H.M. 
Published: March 2021

De schadepost huishoudelijke hulp: op zoek naar handvatten ter invulling van het ‘normaal en gebruikelijk’-criterium
De begroting van de omvang van de schadepost huishoudelijke hulp leidt vaak tot verdeeldheid tussen (belangenbehartigers van) slachtoffers en verzekeraars. Dit is met name het geval wanneer de schadepost niet onder de normering van de Richtlijn Huishoudelijke Hulp van De Letselschade Raad valt. Dit artikel gaat in op de vraag wanneer het inschakelen van professionele huishoudelijke hulp normaal en gebruikelijk is, hetgeen als criterium voor vergoeding van huishoudelijke hulp heeft te gelden. Er worden – na een uitvoerige analyse van de rechtspraak – diverse handvatten aangereikt ter beantwoording van deze vraag.
Les festivités de la mi-carême : un divertissement populaire renouvelé
Authors: Roberge Martine 
Published: March 2021

D’origine française et médiévale, la Mi-Carême a été célébrée dans toutes les régions du Québec de même qu’en Acadie. Ayant atteint leur apogée dans la première moitié du 20e siècle, ces réjouissances collectives, qui consistent à « casser le carême », ont subi ensuite un déclin allant de pair avec l’assouplissement des privations qui marquaient traditionnellement cette période du calendrier liturgique. De nos jours, certaines formes de Mi-Carême actualisées ont survécu dans trois localités du Québec : Fatima aux Îles-de-la-Madeleine, Natashquan sur la Côte-Nord et l’Isle-aux-Grues sur la Côte-du-Sud en face de Montmagny. La situation géographique de ces villages, les voies d’accès limitées, et leur isolement pendant la période hivernale ont-ils favorisé le maintien et la transmission de ces festivités? Sont-elles en continuité avec la tradition ou en rupture avec celle-ci? Un examen minutieux à partir de sources ethnographiques révèle que la pratique n’est pas une survivance mais plutôt une fête renouvelée.
Plasma BDNF concentrations and the antidepressant effects of six ketamine infusions in unipolar and bipolar depression
Authors: Zheng Wei , Zhou Yan-Ling , Wang Cheng-Yu , Lan Xiao-Feng , Zhang Bin , Zhou Su-Miao , Yan Su , Ning Yu-Ping 
Published: March 2021

Objectives
Accumulating evidence has implicated that brain derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of depression, but its correlation with ketamine’s antidepressant efficacy focusing on Chinese individuals with depression is not known. This study was aim to determine the correlation of plasma BDNF (pBDNF) concentrations and ketamine’s antidepressant efficacy.

Methods
Ninety-four individuals with depression received six intravenous infusions ketamine (0.5 mg/kg). Remission and response were defined as Montgomery-Asberg Depression Rating Scale (MADRS) scores less than 10 and a reduction of 50% or more in MADRS scores, respectively. Plasma was collected at baseline and at 24 h and 2 weeks after completing six ketamine infusions (baseline, 13 d and 26 d).

Results
A significant improvement in MADRS scores and pBDNF concentrations was found after completing six ketamine infusions compared to baseline (all ps < 0.05). Higher baseline pBDNF concentrations were found in ketamine responders/remitters (11.0 ± 6.2/10.1 ± 5.8 ng/ml) than nonresponders/nonremitters (8.0 ± 5.5/9.2 ± 6.4 ng/ml) (all ps < 0.05). Baseline pBDNF concentrations were correlated with MADRS scores at 13 d (t = − 2.011, p = 0.047) or 26 d (t = − 2.398, p = 0.019) in depressed patients (all ps < 0.05). Subgroup analyses found similar results in individuals suffering from treatment refractory depression.

Conclusion
This preliminary study suggests that baseline pBDNF concentrations appeared to be correlated with ketamine’s antidepressant efficacy in Chinese patients with depression.
The Role of Biofilm Formation in Antibiotic Resistance of Bacteria Isolated from Saliva of Patients with Dental Caries
Authors: Alwan Merriam Ghadhanfar , Rubaye Hadeel Adil Al , Abood Noor Adil , Ibrahem Hind Tahseen , Hamidon Hamiza Bt , Ahmad Asmat 
Published: March 2021

Objectives: This study aim to determine the bacterial diversity, biofilm forming ability and the antimicrobial resistance of bacteria isolated from saliva of patients with dental caries conditions with the using of 16S rRNA gene sequencing technique for identification of the most virulent isolates.
Methods: Isolation and identification of microorganisms were done employing standard bacteriologic techniques, followed by biofilm detection using tissue culture plate method. The strong biofilm forming isolates were selected for antibiotic susceptibility test against selected antibiotics using disk diffusion technique. In order to identify the selected isolates. The genomic DNA obtained following the extraction process were used for the amplification of the bacterial 16S rRNA gene.
Results: A total of 137 bacterial isolates were obtained and identified as belonging to 21 genera. Tissue culture plate (TCP) method were employed for screening the isolates according to its biofilm forming ability, its showed that 55 (40.1%) of the total isolates were strong, 57 (41.6%) were moderate and 25 (18.3%) were weak biofilm producers. The antimicrobial susceptibility test showed the multi antibiotics resistance of the strong biofilm former isolates to the conventional antibiotics. Enterococcus faecalis isolates showed the highest biofilm formation and antibiotic resistance. The 16S rRNA gene for two of these isolates have been amplified using PCR and the product sequenced, analyzed and registered in the National Center for Biotechnology Information (NCBI) as UKMS1 and UKMS2 and the accession numbers KX960104.1 and KX960105.1 respectively.
Conclusion: The study has revealed that antimicrobial resistance of bacteria isolates from saliva of patients with dental caries conditions is associated with biofilm formation. Other uncommon pathogenic bacteria were also isolated in this study as a result of the use of non-selective enrichment medium for culturing. Enterococcus faecalis isolates indicated the highest biofilm formation and antibiotic resistance.
Development of a strategic approach for comprehensive detection of organophosphate pesticide metabolites in urine: Extrapolation of cadusafos and prothiofos metabolomics data of mice to humans
Authors: Nomasa Karin , Oya Naoko , Ito Yuki , Terajima Takehito , Nishino Takahiro , Mohanto Nayan Chandra , Sato Hirotaka , Tomizawa Motohiro , Kamijima Michihiro 
Published: March 2021

Abstract

Objectives
The comprehensive detection of environmental chemicals in biospecimens, an indispensable task in exposome research, is advancing. This study aimed to develop an exposomic approach to identify urinary metabolites of organophosphate (OP) pesticides, specifically cadusafos and prothiofos metabolites, as an example chemical group, using an original metabolome dataset generated from animal experiments.

Methods
Urine samples from 73 university students were analyzed using liquid chromatography–high-resolution mass spectrometry. The metabolome data, including the exact masses, retention time (tR), and tandem mass spectra obtained from the human samples, were compared with the existing reference databases and with our original metabolome dataset for cadusafos and prothiofos, which was produced from mice to whom two doses of these OPs were orally administered.

Results
Using the existing databases, one chromatographic peak was annotated as 2,4-dichlorophenol, which could be a prothiofos metabolite. Using our original dataset, one peak was annotated as a putative cadusafos metabolite and three peaks as putative prothiofos metabolites. Of these, all three peaks suggestive of prothiofos metabolites, 2,4-dichlorophenol, 3,4,5-trihydroxy-6-(2,4-dichlorophenoxy) oxane-2-carboxylic acid, and (2,4-dichlorophenyl) hydrogen sulfate were confirmed as authentic compounds by comparing their peak data with both the original dataset and peak data of the standard reagents. The putative cadusafos metabolite was identified as a level C compound (metabolite candidate with limited plausibility).

Conclusions
Our developed method successfully identified prothiofos metabolites that are usually not a target of biomonitoring studies. Our approach is extensively applicable to various environmental contaminants beyond OP pesticides.
Health outcomes of psychosocial stress within firefighters: A systematic review of the research landscape
Authors: Igboanugo Somkene , Bigelow Philip L , Mielke John G 
Published: March 2021

Abstract

Background and Objectives
Much of the research surrounding firefighter health has concerned the hazards intuitively associated with the occupation, such as physical, thermal, and chemical risks. However, an additional aspect of their work environment, psychosocial stressors, has begun to attract a growing level of attention. Work-related psychosocial stress may best be described as mental and emotional strain caused by a combination of workplace events and characteristics, and the objective of our review was to identify the health outcomes associated with these stressors in firefighters.

Methods
A systematic review was performed of studies reporting on the psychosocial stressors and the associated health outcomes experienced by firefighters. Data sources included the MEDLINE, PsychInfo, and CINAHL databases.

Results
Twenty-nine studies met the inclusion criteria. Upon analysis, we found that firefighters experienced a range of psychosocial stressors (including interpersonal conflict and concerns over organizational fairness) and observed that these stressors were associated with a number of health-related outcomes that could be arranged into six areas: depression-suicidality, non-depressive mental health problems, burnout, alcohol use disorders, sleep quality, and physiological parameters and somatic disorders.

Conclusion
Our findings strongly suggest that work-related psychosocial stressors can affect the health and well-being of those in the fire service, and highlight that interventions meant to address these psychosocial risk factors should focus upon promoting self-esteem, enhancing self-efficacy, and strengthening social support.
Role of p40phox in host defense against Citrobacterrodentium infection
Authors: Yan Yanyun , Li Yali , Lv Meili , Li Weifen , Shi Hai Ning 
Published: March 2021

NADPH oxidase (NOX) is a membrane‐bound enzyme complex that generates reactive oxygen species (ROS). Mutations in NOX subunit genes have been implicated in the pathogenesis of inflammatory bowel disease (IBD), indicating a crucial role for ROS in regulating host immune responses. In this study, we utilize genetically deficient mice to investigate whether defects in p40phox, one subunit of NOX, impair host immune response in the intestine and aggravate disease in an infection‐based (Citrobacter rodentium) model of colitis. We show that p40phox deficiency does not increase susceptibility of mice to C. rodentium infection, as no differences in body weight loss, bacterial clearance, colonic pathology, cytokine production, or immune cell recruitment were observed between p40phox−/− and wild‐type mice. Interestingly, higher IL‐10 levels were observed in the supernatants of MLN cells and splenocytes isolated from infected p40phox‐deficient mice. Further, a higher expression level of inducible nitric oxide synthase (iNOS) was also noted in mice lacking p40phox. In contrast to wild‐type mice, p40phox−/− mice exhibited greater NO production after LPS or bacterial antigen re‐stimulation. These results suggest that p40phox−/− mice do not develop worsened colitis. While the precise mechanisms are unclear, it may involve the observed alteration in cytokine responses and enhancement in levels of iNOS and NO.
Nano‐Ground Glass as a Superhydrophilic Template for Printing High‐Performance Organic Single‐Crystal Thin Films
Authors: Makita Tatsuyuki , Ninomiya Yoma , Kumagai Shohei , Okamoto Toshihiro , Sasaki Mari , Watanabe Shun , Takeya Jun 
Published: March 2021

AbstractThin‐film devices are typically fabricated through a bottom‐up approach, wherein the constituents are deposited sequentially from the bottom to top layer. This method requires the precise management of the heterointerfaces, which leads to complicated integration issues particularly in solution‐processed organic thin‐film transistors (OTFTs). This limitation arises because a surface suitable for the printing of semiconductors is not necessarily suitable for maximizing the electronic properties of OTFTs. To overcome this, a transfer technique of organic semiconductor (OSC) thin films has been studied. This enables facile transfer of the OSC thin film from a hydrophilic template to any given substrate; thus, the printing substrate and destination substrate can be optimized individually. Here, a nano‐ground glass (NGG) is developed whose surface is chemically etched using a mild base. The NGG functions as a thermally stable, superhydrophilic template for printing high‐quality single‐crystal OSC thin films. To evaluate the practical applicability of the NGG, an n‐type OSC, which requires a relatively high temperature of around 150 °C during crystal growth, is fabricated. The fabricated OTFTs exhibit an outstanding electron mobility of 2.2 cm2 V−1 s−1. The NGG proposed in this study can be utilized for the fabrication of a wide variety of printable materials.
Cancer models in preclinical research: A chronicle review of advancement in effective cancer research
Authors: Sajjad Humna , Imtiaz Saiqa , Noor Tayyaba , Siddiqui Yusra Hasan , Sajjad Anila , Zia Muhammad 
Published: March 2021

AbstractCancer is a major stress for public well‐being and is the most dreadful disease. The models used in the discovery of cancer treatment are continuously changing and extending toward advanced preclinical studies. Cancer models are either naturally existing or artificially prepared experimental systems that show similar features with human tumors though the heterogeneous nature of the tumor is very familiar. The choice of the most fitting model to best reflect the given tumor system is one of the real difficulties for cancer examination. Therefore, vast studies have been conducted on the cancer models for developing a better understanding of cancer invasion, progression, and early detection. These models give an insight into cancer etiology, molecular basis, host tumor interaction, the role of microenvironment, and tumor heterogeneity in tumor metastasis. These models are also used to predict novel cancer markers, targeted therapies, and are extremely helpful in drug development. In this review, the potential of cancer models to be used as a platform for drug screening and therapeutic discoveries are highlighted. Although none of the cancer models is regarded as ideal because each is associated with essential caveats that restraint its application yet by bridging the gap between preliminary cancer research and translational medicine. However, they promise a brighter future for cancer treatment.
Down‐Regulation of Dkk‐1 in Platelets of Patients With Axial Spondyloarthritis
Authors: Czepiel Marcin , Stec Małgorzata , Korkosz Mariusz , Guła Zofia , Błyszczuk Przemysław , Baran Jarosław , Siedlar Maciej 
Published: March 2021

ObjectiveAxial spondyloarthritis (SpA) is a chronic autoinflammatory disease with new bone formation, which is controlled by Wnt/β‐catenin signaling. Dkk‐1 is an inhibitor of the Wnt pathway, and in humans, platelets represent a major source of Dkk‐1. This study was undertaken to investigate whether levels of Dkk‐1 in serum and platelet expression of DKK1 messenger RNA (mRNA) and Dkk‐1 protein are affected in patients with axial SpA compared to healthy controls.MethodsForty‐one patients with axial SpA and 35 healthy controls were enrolled in the study. Total serum Dkk‐1 levels in all patients and healthy controls were measured by quantitative enzyme‐linked immunosorbent assay. Platelet DKK1 mRNA was analyzed by quantitative reverse transcriptase–polymerase chain reaction in 20 patients with axial SpA and 20 controls, and Dkk‐1 protein levels were measured by immunoblotting in 20 patients with axial SpA and 18 controls.ResultsWe found a lower concentration of Dkk‐1 in the serum from patients with axial SpA compared to the serum from healthy controls (P < 0.0001). Furthermore, the expression of Dkk‐1 was significantly reduced both at the transcriptional level (P < 0.04) and at the protein level (P < 0.007) in platelets isolated from the blood of patients with axial SpA.ConclusionOur preliminary observations suggest that dysfunction of the megakaryocyte/platelet axis might be responsible for reduced serum Dkk‐1 levels in patients with axial SpA. Dkk‐1 is down‐regulated in the platelets of patients with axial SpA, a mechanism that might play a role in new bone formation.