bluuebunny/crossref_metadata_2025_split huggingface dataset:
QbD approach to HPLC method development and validation of ceftriaxone sodium
Authors: Patel Krunal Y. , Dedania Zarna R. , Dedania Ronak R. , Patel Unnati 
Published: July 2021

Abstract
Background
Quality by design (QbD) refers to the achievement of certain predictable quality with desired and predetermined specifications. A quality-by-design approach to method development can potentially lead to a more robust/rugged method due to emphasis on risk assessment and management than traditional or conventional approach. An important component of the QbD is the understanding of dependent variables, various factors, and their interaction effects by a desired set of experiments on the responses to be analyzed. The present study describes the risk based HPLC method development and validation of ceftriaxone sodium in pharmaceutical dosage form.

Results
An efficient experimental design based on central composite design of two key components of the RP-HPLC method (mobile phase and pH) is presented. The chromatographic conditions were optimized with the Design Expert software 11.0 version, i.e., Phenomenex ODS column C18 (250 mm × 4.6 mm, 5.0 μ), mobile phase used acetonitrile to water (0.01% triethylamine with pH 6.5) (70:30, v/v), and the flow rate was 1 ml/min with retention time 4.15 min. The developed method was found to be linear with r2 = 0.991 for range of 10–200 μg/ml at 270 nm detection wavelength. The system suitability test parameters, tailing factor and theoretical plates, were found to be 1.49 and 5236. The % RSD for intraday and inter day precision was found to be 0.70–0.94 and 0.55–0.95 respectively. The robustness values were less than 2%. The assay was found to be 99.73 ± 0.61%. The results of chromatographic peak purity indicate the absence of any coeluting peaks with the ceftriaxone sodium peak. The method validation parameters were in the prescribed limit as per ICH guidelines.

Conclusion
The central composite design experimental design describes the interrelationships of mobile phase and pH at three different level and responses to be observed were retention time, theoretical plates, and peak asymmetry with the help of the Design Expert 11.0 version. Here, a better understanding of the factors that influence chromatographic separation with greater confidence in the ability of the developed HPLC method to meet their intended purposes is done. The QbD approach to analytical method development was used for better understanding of method variables with different levels.
Submandibular ectopic thyroid gland: an uncommon presentation
Authors: Riahi Inès , Fradi Rim , Ben Nacef Ibtissem , Blel Ahlem 
Published: July 2021

Abstract
Background
Ectopic thyroid is a developmental anomaly of the thyroid gland of embryological origin. Instead of having a pretracheal situation, thyroid tissue is elsewhere, most commonly in the median cervical line along the course of the thyroglossal duct. Lingual thyroid is the most common presentation. Ectopic thyroid tissue in the submandibular region has been rarely reported.

Case presentation
We report herein a case of a 65-year-old man admitted to our department with a complaint of a painless swelling in the left submandibular region.

Conclusions
Thyroid gland ectopia should be considered among the differential diagnoses of submandibular swelling. Ectopic thyroid tissue can present with the same pathology affecting the normal thyroid gland such as malignancy and hyperthyroidism.
Temporal bone rhabdomyosarcoma mimicking otitis media complicated by facial nerve palsy
Authors: Galal Ahmed , Ahmed Omneya , Rizk Azza M. , Tayel Hanan Yehia , Aly Rania G. 
Published: July 2021

Abstract
Background
Rhabdomyosarcoma is common in childhood, especially, the head and neck region, yet involvement of the temporal bone is rare.

Case presentation
We reported a case of an embryonal rhabdomyosarcoma in a 4.5-year-old boy presenting with external auditory canal polyp and purulent otorrhea that later developed grade 6 facial palsy. Imaging showed soft tissue mass involving the middle ear, mastoid cavity, parotid gland, and parapharyngeal space. Subtotal petrosectomy with blind closure of the external auditory canal was performed with facial nerve decompression and debulking biopsy followed by combined chemoradiation.

Conclusion
Middle ear rhabdomyosarcoma is a rare pathology, usually present in childhood by symptoms similar to suppurative otitis media not responding to medical treatment leading to delayed diagnosis and development of complications.
Risk perception and adherence to preventive behaviours related to the COVID-19 pandemic: a community-based study applying the health belief model
Authors: Kamran Aziz , Isazadehfar Khatereh , Heydari Heshmatolah , Nasimi Doost Azgomi Ramin , Naeim Mahdi 
Published: July 2021

Background
Coronavirus disease 2019 (COVID-19), now a global pandemic, is a new, highly contagious, and preventable disease that has caused many deaths across the world. Correct understanding of the risks and following health instructions are among the most important self-care parameters.

Aims
To assess people's perception of the risks and their adherence to recommended preventive behaviours regarding COVID-19 infection.

Method
This descriptive–analytical study was conducted with 1861 people residing in Ardabil province in 2020. The data were collected electronically and included four elements: demographic details; health belief model (HBM) constructs (perceived sensitivity, perceived severity and perceived benefits); beliefs about the effectiveness of disease prevention strategies; and complying with health behaviours. The data was analysed using SPSS-21 software.

Results
Significant differences were found in the mean scores for beliefs about the effectiveness of preventative measures, the constructs of the health belief model, and compliance with preventive behaviours relating to the participants’ gender, age, marital status and level of education. Beliefs and intention to stay at home, collectively predicted 54.7% of the variance in preventive behaviours.

Conclusions
Although a majority of participants had positive attitudes towards the effectiveness of preventive measures and adhered to them, some people who were not adherent with these healthy behaviours could be key participants in the next wave of the disease.
The relationship between attention and avoidance coping in anorexia nervosa: functional magnetic resonance imaging study
Authors: Noda Tomomi , Isobe Masanori , Ueda Keita , Aso Toshihiko , Murao Ema , Kawabata Michiko , Noma Shun'ichi , Murai Toshiya 
Published: July 2021

Background
Numerous studies have demonstrated attentional control difficulties and high avoidance coping in patients with anorexia nervosa. Attention is a critical coping resource because it enables individuals to demonstrate self-control and complete goal-directed behaviours.

Aims
We aimed to examine whether attentional control difficulty is related to high avoidance coping, and investigate the neural underpinnings of attentional control difficulties in individuals with anorexia nervosa.

Method
Twenty-three patients with anorexia nervosa and 17 healthy controls completed questionnaires that assessed attention and coping, and underwent functional magnetic resonance imaging while performing a go/no-go task.

Results
Patients with anorexia nervosa showed weaker attentional control, higher omission error rates and higher avoidance coping compared with healthy controls. Attentional control difficulty was associated with higher avoidance coping in both groups. Functional magnetic resonance imaging analysis showed less deactivation in regions representing internal mental processing, such as the praecuneus, cuneus and left lingual gyrus, during the no-go condition. Moreover, weakened deactivation of the left lingual gyrus was associated with higher commission error rate in the anorexia nervosa group.

Conclusions
Our results suggest that patients with anorexia nervosa may have difficulty in maintaining attention to external ongoing events because of disturbance from internal self-related thought, and support the notion that attentional control difficulties underlie the frequent use of avoidance coping in anorexia nervosa.
Esophagectomy or Total Gastrectomy for Siewert 2 Gastroesophageal Junction (GEJ) Adenocarcinoma? A Registry-Based Analysis
Authors: Kamarajah Sivesh K. , Phillips Alexander W. , Griffiths Ewen A. , Ferri Lorenzo , Hofstetter Wayne L. , Markar Sheraz R. 
Published: July 2021

Abstract
Backgrounds
Due to a lack of randomized and large studies, the optimal surgical approach for Siewert 2 gastroesophageal junctional (GEJ) adenocarcinoma remains unknown. This population-based cohort study aimed to compare survival between esophagectomy and total gastrectomy for the treatment of Siewert 2 GEJ adenocarcinoma.

Methods
Data from the National Cancer Database (NCDB) from 2010 to 2016 was used to identify patients with non-metastatic Siewert 2 GEJ adenocarcinoma who received either esophagectomy (n = 999) or total gastrectomy (n = 8595). Propensity score-matching (PSM) and multivariable analyses were used to account for treatment selection bias.

Results
Comparison of the unmatched cohort’s baseline demographics showed that the patients who received esophagectomy were younger, had a lower burden of medical comorbidities, and had fewer clinical positive lymph nodes. The patients in the unmatched cohort who received gastrectomy had a significantly shorter overall survival than those who received esophagectomy (median, 47 vs. 68 months [p < 0.001]; 5-year survival, 45 % vs. 53 %). After matching, gastrectomy was associated with significantly reduced survival compared with esophagectomy (median, 51 vs. 68 months [p < 0.001]; 5-year survival, 47 % vs. 53 %), which remained in the adjusted analyses (hazard ratio [HR], 1.22; 95 % confidence interval [CI], 1.09–1.35; p < 0.001).

Conclusions
In this large-scale population study with propensity-matching to adjust for confounders, esophagectomy was prognostically superior to gastrectomy for the treatment of Siewert 2 GEJ adenocarcinoma despite comparable lymph node harvest, length of stay, and 90-day mortality. Adequately powered randomized controlled trials with robust surgical quality assurance are the next step in evaluating the prognostic outcomes of these surgical strategies for GEJ cancer.
Enhancement of pyocyanin production by subinhibitory concentration of royal jelly in Pseudomonas aeruginosa
Authors: Amly Dina Auliya , Hajardhini Puspita , Jonarta Alma Linggar , Yulianto Heribertus Dedy Kusuma , Susilowati Heni 
Published: July 2021

Background: Pseudomonas aeruginosa, a multidrug-resistant Gram-negative bacterium, produces pyocyanin, a virulence factor associated with antibiotic tolerance. High concentrations of royal jelly have an antibacterial effect, which may potentially overcome antibacterial resistance. However, in some cases, antibiotic tolerance can occur due to prolonged stress of low-dose antibacterial agents. This study aimed to investigate the effect of subinhibitory concentrations of royal jelly on bacterial growth, pyocyanin production, and biofilm formation of P. aeruginosa. Methods: Pseudomonas aeruginosa ATCC 10145 and clinical isolates were cultured in a royal jelly-containing medium to test the antibacterial activity. Pyocyanin production was observed by measuring the absorbance at 690 nm after 36 h culture and determined using extinction coefficient 4310 M-1 cm-1. Static microtiter plate biofilm assay performed to detect the biofilm formation, followed by scanning electron microscopy. Results: Royal jelly effectively inhibited the viability of both strains from a concentration of 25%. The highest production of pyocyanin was observed in the subinhibitory concentration group 6.25%, which gradually decreased along with the decrease of royal jelly concentration. Results of one-way ANOVA tests differed significantly in pyocyanin production of the two strains between the royal jelly groups. Tukey HSD test showed concentrations of 12.5%, 6.25%, and 3.125% significantly increased pyocyanin production of ATCC 10145, and the concentrations of 12.5% and 6.25% significantly increased production of the clinical isolates. Concentrations of 12.5% and 6.125% significantly induced biofilm formation of P. aeruginosa ATCC 10145, in line with the results of the SEM analysis. Conclusions: Royal jelly concentrations of 25% or higher can inhibit bacterial growth; however, subinhibitory concentrations could increase pyocyanin production and biofilm formation in P. aeruginosa. It is advisable to determine the appropriate concentration of royal jelly to obtain beneficial virulence inhibiting activity.
The storm that was delayed: the deterioration of an in-hospital diabetes process-of-care metric during the COVID-19 pandemic
Authors: Barmanray Rahul D , Tsan Joshua , Kyi Mervyn , Gorelik Alexandra , Fourlanos Spiros 
Published: July 2021

Background/AimsNetworked glucose blood monitoring has been demonstrated as a useful process of care for improving glycaemia and clinical outcomes in hospital inpatients. However, these benefits are partly reliant on the accurate entry of patients' medical record numbers by healthcare staff. This study assessed the accuracy of such data entry, comparing the periods before and after the onset of the COVID-19 pandemic.MethodsThis retrospective observational study analysed glucose meter medical record number entries at a large hospital in Victoria, Australia. The study period spanned from September 2019, when the networked blood glucose monitoring system was introduced, to July 2020. The proportion of inaccurate entries were presented as a percentage of the total number of entries and comparisons were made between the pre-COVID-19 and post-COVID-19 onset periods. Data were analysed using an interrupted time series methodology and presented using a Quasipoisson distribution.ResultsA gradual decrease in the percentage of accurate medical record number entries was observed following the introduction of the networked blood glucose monitoring system. This decline in accuracy decreased further following the onset of COVID-19, despite the hospital serving a relatively low number of patients with the virus.ConclusionsThe ongoing decrease in accuracy of data entry into the networked blood glucose monitoring system is thought to be a result of insufficient training and time constraints, which were exacerbated by the COVID-19 pandemic because of protocol changes and furloughed staff. It is recommended that accurate use of the networked blood glucose monitoring system is allocated more regular training in hospital wards.
Is it civic duty? An exploratory study of factors that influenced the public's decision to download the NHS COVID-19 app
Authors: Phillips Peter , Darby Iain , Phillips Louise , Wicks Ashley 
Published: July 2021

Background/Aims The UK Government piloted a COVID-19 digital contact tracing smartphone app on the Isle of Wight, England, in June 2020 in attempt to contain the spread of the virus. This study aimed to investigate the factors that affected the decision to download the app among individuals in the Isle of Wight. Methods Online questionnaires were distributed over social media to the sample population. Quantitative data were analysed, both descriptively and using a Chi-square or Fisher's test. Qualitative data were analysed through content analysis. Results Overall, 74.2% of participants downloaded the COVID-19 app, citing compliance, protection and fighting the pandemic or returning to normal as their main reasons. There was a significant negative correlation between having concerns about the app and downloading the app (P=<0.01). Concerns were split into the three themes of privacy or data security concerns, technology issues and increased complacency. There was a significant negative correlation between being in a COVID-19 high-risk group and downloading the app (P=0.042). Conclusions Concerns about the COVID-19 app, particularly in terms of its security, significantly affected whether participants were likely to download it. The results provide insight into factors influencing mass public health behaviours and can form the basis for future research into app-based interventions.
Management of non-cystic fibrosis bronchiectasis
Authors: Webb Philip , King Jenny , Baxter Caroline , Lord Robert W 
Published: July 2021

Bronchiectasis is a common respiratory condition, characterised by abnormal bronchial dilatation, that often leads to recurrent airway infection and inflammation. It is an increasingly recognised respiratory condition, both as a primary lung disease but also co-existing with other respiratory diseases, such as chronic obstructive pulmonary disease and asthma. Diagnosis can have important treatment implications. There are shared systematic approaches to treatment, such as sputum clearance techniques, prompt treatment of exacerbations and, in certain circumstances, regular antibiotic therapy. It is vital to target antibiotic therapy appropriately, and knowledge of the patient's airway microbiology can assist with this. Certain infective and colonising organisms, such as Pseudomonas aeruginosa, cause worse patient outcomes and so need prompt treatment with appropriate antibiotics. In addition to this general management approach, there are many different underlying causes of bronchiectasis that should be identified wherever possible, to support more targeted therapy and prevent disease progression. This article provides a guide to the key principles of diagnosing and managing bronchiectasis, and outlines situations where more specialist respiratory support is required.
Evolutionary Autonomous Networks
Authors: Harvey Paul , Tatar Alexandru , Imai Pierre , Wong Leon , Bringuier Laurent 
Published: July 2021

The communication networks of today can greatly benefit from autonomous operation and adaptation, not only due to the implicit cost savings, but also because autonomy will enable functionalities that are infeasible today. Across industry, academia and standardisation bodies there has been an increased interest in achieving the autonomous goal, but a path on how to attain this goal is still unclear.
In this paper we present our vision for the future of autonomous networking. We introduce the concepts and technological means to achieve autonomy and propose an architecture which emerges directly through the application of these concepts, highlighting opportunities and challenges for standardisation. We argue that only a holistic architecture based on hierarchies of hybrid learning, functional composition, and online experimental evaluation is expressive and capable enough to realise true autonomy within communication networks.
Dynamic Modeling and Closed-Loop Control of a Tapped Inductor Buck Converter
Authors: Trakuldit Siripan , Bunlaksananusorn Chanin 
Published: July 2021

Modern smart electronic and information technology (IT) devices require a low DC voltage for operation. The low supply voltage is typically provided by a dedicated DC−DC converter by stepping down the system’s bus voltage (e.g., 12 V). It is essential that the converter possesses a large voltage step-down gain and, at the same time, operates at high efficiency. A tapped inductor buck converter (TIBC) is a topology that has a potential to meet these requirements. It has a simple circuit structure and high efficiency similar to a buck converter, but can give a larger voltage step-down gain. This paper presents a dynamic modeling and closed-loop control of a TIBC. The state space averaging (SSA) method is adopted for the dynamic modeling to derive small-signal transfer functions of the converter. Based on the duty-cycle-to-output voltage transfer function, a closed-loop control is designed to keep the converter’s output voltage constant. To verify the design, a prototype TIBC with closed-loop control is implemented. Experimental results show that the prototype converter has good output voltage regulation and fast transient response when subject to a step load. The effect of the crossover frequency and phase margin on the converter’s transient response is also illustrated.
Transformation Approach of Open Web Data to Linked Open Data
Authors: Meherehera Amina , Mekideche Imane , Zemmouchi-Ghomari Leila , Ghomari Abdessamed Réda 
Published: July 2021

A large amount of data available over the Web and, in particular, the open data have, generally, heterogeneous formats and are not machine-readable. One promising solution to overcome the problems of heterogeneity and automatic interpretation is the Linked Data initiative, which aims to provide unified practices for publishing and contextually to link data on the Web, by using World Wide Web Consortium standards and the Semantic Web technologies. LinkedIn data promote the Web’s transformation from a web of documents to a web of data, ensuring that machines and software agents can interpret the semantics of data correctly and therefore infer new facts and return relevant web data search results.
This paper presents an automatic generic transformation approach that manipulates several input formats of open web data to linked open data. This work aims to participate actively in the movement of publishing data compliant with linked data principles.
Describing youth as actionists for peer sexual violence prevention: correlates of opportunity to act
Authors: Banyard Victoria , Edwards Katie , Mitchell Kimberly J. , Greenberg Patricia , Jones Lisa 
Published: July 2021

Objective:An emerging prevention strategy to reduce peer sexual violence among adolescents is bystander training (that is, actionism). The situational-cognitive model of actionism describes key variables that may promote action, the first of which is detecting the opportunity to help. The purpose of this study was to examine this first stage of action to better understand youth who report opportunity to respond to situations of sexual violence.
Method:The current cross-sectional study examined a measure of youth bystander opportunity in a baseline sample of youth in school grades 7–10 in the Great Plains region of the US (N=2,225). Students indicated whether they witnessed four situations related to risk of peer sexual violence.
Results:Opportunities for actionism varied based on the type of situation. Opportunities to intervene were most common for situations involving unwanted touching and sexual rumours. Older youth, girls and youth with self-reported risk factors such as alcohol use and internalising symptoms were more likely to report opportunities for actionism.
Discussion:Further study of bystander opportunity and correlates of bystander opportunity could help better tailor prevention approaches to provide practice in strategies that are based on the range of opportunities which particular groups of youth may be most likely to encounter.