bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adalimumab biosimilars, ABP501 and SB5, are equally effective and safe as adalimumab originator
Authors: Cingolani Linda , Barberio Brigida , Zingone Fabiana , Ferronato Antonio , Bertani Lorenzo , Costa Francesco , Bodini Giorgia , Demarzo Maria Giulia , Melatti Piera , Gubbiotti Alessandro , Massimi Davide , Casadei Cesare , D’Incà Renata , Savarino Edoardo Vincenzo 
Published: May 2021

AbstractTo date, data on effectiveness and safety of Adalimumab (ADA) biosimilars in inflammatory bowel diseases (IBDs) are lacking. Therefore, we aimed to verify the ability of ABP501 and SB5 to maintain the clinical and biochemical response induced by the ADA originator, after switching to them. We prospectively analyzed data collected from 55 patients with IBD who switched to ABP501, and 25 patients with IBD who switched to SB5, from ADA originator at four IBD Units between 2018 and 2020. In addition, we included an age and sex-matched control group (n = 38) who continued ADA originator for at least two years and who did not switch to a biosimilar drug. Clinical and biochemical data (C-Reactive Protein (CRP), fecal calprotectin (FC)), concomitant steroid and/or immunosuppressant therapy at the time of the switch and after six months were collected. At six months, in the ABP501 group, we did not observe statistically significant modifications in clinical activity of disease (p = 0.09) and FC values (p = 0.90). Some patients (n = 8) needed to add steroids at six months after switching (p = 0.01), however the need for optimization was not significant between the two timepoints (p = 0.70). Finally, 14.5% patients stopped therapy after six months. Similarly, in the SB5 group we observed a stability of clinical activity and FC values (p = 0.90 and p = 0.20), and a concomitant statistically significant decrease in CRP (p = 0.03). There were no differences in steroids/immunosuppressants need or optimizing biological therapy in this group. Finally, drug survival curves of patients who switched from originator to ABP501 and those who continued ADA originator were similar (p = 0.20). Overall, biosimilar drugs seem to be as effective and safe as the originator. Further larger and longer studies are mandatory to understand the clinical implications of these findings.
Impact of selenium addition to the cadmium-zinc-telluride matrix for producing high energy resolution X-and gamma-ray detectors
Authors: Roy Utpal N. , Camarda Giuseppe S. , Cui Yonggang , Yang Ge , James Ralph B. 
Published: May 2021

AbstractBoth material quality and detector performance have been steadily improving over the past few years for the leading room temperature radiation detector material cadmium-zinc-telluride (CdZnTe). However, although tremendous progress being made, CdZnTe still suffers from high concentrations of performance-limiting defects, such as Te inclusions, networks of sub-grain boundaries and compositional inhomogeneity due to the higher segregation coefficient of Zn. Adding as low as 2% (atomic) Se into CdZnTe matrix was found to successfully mitigate many performance-limiting defects and provide improved compositional homogeneity. Here we report record-high performance of Virtual Frisch Grid (VFG) detector fabricated from as-grown Cd0.9Zn0.1Te0.98Se0.02 ingot grown by the Traveling Heater Method (THM). Benefiting from superior material quality, we achieved superb energy resolution of 0.77% at 662 keV (as-measured without charge-loss correction algorithms) registered at room temperature. The absence of residual thermal stress in the detector was revealed from white beam X-ray topographic images, which was also confirmed by Infra-Red (IR) transmission imaging under cross polarizers. Furthermore, neither sub-grain boundaries nor their networks were observed from the X-ray topographic image. However, large concentrations of extrinsic impurities were revealed in as-grown materials, suggesting a high likelihood for further reduction in the energy resolution after improved purification of the starting material.
A randomized clinical trial evaluating the short-term results of ureteral stent encrustation in urolithiasis patients undergoing ureteroscopy: micro-computed tomography evaluation
Authors: Yoshida Takashi , Takemoto Kuniko , Sakata Yoshiko , Matsuzaki Tomoaki , Koito Yuya , Yamashita Shimpei , Hara Isao , Kinoshita Hidefumi , Matsuda Tadashi 
Published: May 2021

AbstractAlthough many ureteral stents are commercially available, the actuality of encrustation is yet to be elucidated in humans. This study compared the Tria Ureteral Stent with PercuShield and the Polaris Ultra Ureteral Stent with HydroPlus Coating for short-term encrustation formation. Eighty-four patients, who required ureteral stent placement after ureteroscopy, were randomized into two stent groups. After stent removal on postoperative day 14, the encrustation volume on the stent surface was measured by micro-computed tomography. The primary outcome was the inner luminal encrustation volume. Secondary outcomes were encrustation volume on the outer or total surfaces and occurrence of adverse events. Clinical factors related to encrustation were also assessed as a post-hoc analysis. Finally, of the 82 patients analyzed, 75 (91.5%) had encrustation in the inner lumen of the stent. The difference in median inner encrustation volume between the Tria and Polaris Ultra stents was comparable (0.56 vs. 0.37 mm3,P = 0.183). There was no difference observed in the encrustation volume on the outer/total surfaces and stent-related adverse events. In both ureteral stents, the shaft body showed significant inner luminal encrustation compared to the proximal or distal loop (all,P < 0.05). Dyslipidemia (P = 0.027), elevated urine pH (P = 0.046), and crystalluria (P = 0.010) were associated with encrustation formation. The Tria and Polaris Ultra stents had similar efficacy for preventing encrustation in the short-term. Further studies are required to compare their long-term patency.
Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
Authors: Wang Qun , Ji Peng , Yao Yansheng , Liu Yi , Zhang Yajie , Wang Xianglong , Wang Yuhang , Wu Jinyan 
Published: May 2021

AbstractThe development of inorganic antibacterial agents that impart antibacterial properties to biomaterials has attracted wide attention. The paper introduced a kind of hybrid nanosphere antibacterial agent composed of wheat gliadin (WG) and zinc oxide (ZnO), with antibacterial efficacy and low toxicity. The ZnO/WG hybrid nanospheres were environment-friendly integrated by molecular self-assembly co-precipitating and freeze-drying transformation, and were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic absorption spectroscopy (AAS), specific surface and pore size analysis, bacteriostasis test, reactive oxygen species (ROS) determination and safety evaluation. It was found that the prepared hybrid nanospheres were composed of two components, WG and ZnO, with a diameter scope of 100–200 nm; the content of ZnO in the hybrid nanospheres can reach 46.9–70.2% (w/w); the bacteriostasis tests proved that the prepared ZnO/WG nanospheres generating ROS, have a significant inhibitory effect on E. coli and S. aureus; furthermore, the ZnO/WG nanospheres are relatively safe and highly biocompatible in cells and mice. Therefore, the prepared novel ZnO/WG hybrid nanospheres were supposed to apply in the preparation of anti-infective wound dressings, tissue engineering skin scaffold materials, food, and cosmetics preservatives, and so on.
Radioactivity and radionuclides in deciduous teeth formed before the Fukushima-Daiichi Nuclear Power Plant accident
Authors: Takahashi Atsushi , Chiba Mirei , Tanahara Akira , Aida Jun , Shimizu Yoshinaka , Suzuki Toshihiko , Murakami Shinobu , Koarai Kazuma , Ono Takumi , Oka Toshitaka , Ikeyama Joji , Kaneko Osamu , Unno Makoto , Hirose Kimiharu , Ohno Takashi , Kino Yasushi , Sekine Tsutomu , Osaka Ken , Sasaki Keiichi , Shinoda Hisashi 
Published: May 2021

AbstractThe Fukushima-Daiichi Nuclear Power Plant (FNPP) accident in March of 2011 released substantial amounts of radionuclides into the environment. We collected 4,957 deciduous teeth formed in children before the Fukushima accident to obtain precise control data for teeth formed after the accident. Radioactivity was measured using imaging plates (IP) and epidemiologically assessed using multivariate regression analysis. Additionally, we measured 90Sr, 137Cs, and natural radionuclides which might be present in teeth. Epidemiological studies of IP showed that the amount of radioactivity in teeth from Fukushima prefecture was similar to that from reference prefectures. We found that artificial radionuclides of 90Sr and 137Cs, which were believed to have originated from past nuclear disasters, and natural radionuclides including 40 K and daughter nuclides in the 238U and 232Th series contributed to the generation of radioactivity in teeth. We also found no evidence to suggest that radionuclides originating from the FNPP accident significantly contaminated pre-existing teeth. This is the first large-scale investigation of radioactivity and radionuclides in teeth. The present findings will be indispensable for future studies of teeth formed after the FNPP accident, which will fall out over the next several years and might be more contaminated with radionuclides.
Ab initio prediction of semiconductivity in a novel two-dimensional Sb2X3 (X= S, Se, Te) monolayers with orthorhombic structure
Authors: Bafekry A. , Mortazavi B. , Faraji M. , Shahrokhi M. , Shafique A. , Jappor H. R. , Nguyen C. , Ghergherehchi M. , Feghhi S. A. H. 
Published: May 2021

Abstract$$\hbox {Sb}_2\hbox {S}_3$$

Sb
2

S
3

and $$\hbox {Sb}_2\hbox {Se}_3$$

Sb
2

Se
3

are well-known layered bulk structures with weak van der Waals interactions. In this work we explore the atomic lattice, dynamical stability, electronic and optical properties of $$\hbox {Sb}_2\hbox {S}_3$$

Sb
2

S
3

, $$\hbox {Sb}_2\hbox {Se}_3$$

Sb
2

Se
3

and $$\hbox {Sb}_2\hbox {Te}_3$$

Sb
2

Te
3

monolayers using the density functional theory simulations. Molecular dynamics and phonon dispersion results show the desirable thermal and dynamical stability of studied nanosheets. On the basis of HSE06 and PBE/GGA functionals, we show that all the considered novel monolayers are semiconductors. Using the HSE06 functional the electronic bandgap of $$\hbox {Sb}_2\hbox {S}_3$$

Sb
2

S
3

, $$\hbox {Sb}_2\hbox {Se}_3$$

Sb
2

Se
3

and $$\hbox {Sb}_2\hbox {Te}_3$$

Sb
2

Te
3

monolayers are predicted to be 2.15, 1.35 and 1.37 eV, respectively. Optical simulations show that the first absorption coefficient peak for $$\hbox {Sb}_2\hbox {S}_3$$

Sb
2

S
3

, $$\hbox {Sb}_2\hbox {Se}_3$$

Sb
2

Se
3

and $$\hbox {Sb}_2\hbox {Te}_3$$

Sb
2

Te
3

monolayers along in-plane polarization is suitable for the absorption of the visible and IR range of light. Interestingly, optically anisotropic character along planar directions can be desirable for polarization-sensitive photodetectors. Furthermore, we systematically investigate the electrical transport properties with combined first-principles and Boltzmann transport theory calculations. At optimal doping concentration, we found the considerable larger power factor values of 2.69, 4.91, and 5.45 for hole-doped $$\hbox {Sb}_{{2}}\hbox {S}_{{3}}$$

Sb
2

S
3

, $$\hbox {Sb}_{{2}}\hbox {Se}_{{3}}$$

Sb
2

Se
3

, and $$\hbox {Sb}_{{2}}\hbox {Te}_{{3}}$$

Sb
2

Te
3

, respectively. This study highlights the bright prospect for the application of $$\hbox {Sb}_2\hbox {S}_3$$

Sb
2

S
3

, $$\hbox {Sb}_2\hbox {Se}_3$$

Sb
2

Se
3

and $$\hbox {Sb}_2\hbox {Te}_3$$

Sb
2

Te
3

nanosheets in novel electronic, optical and energy conversion systems.
Resolving few-layer antimonene/graphene heterostructures
Authors: Gupta Tushar , Elibol Kenan , Hummel Stefan , Stöger-Pollach Michael , Mangler Clemens , Habler Gerlinde , Meyer Jannik C. , Eder Dominik , Bayer Bernhard C. 
Published: May 2021

AbstractTwo-dimensional (2D) antimony (Sb, “antimonene”) is of interest in electronics and batteries. Sb however exhibits a large allotropic structural diversity, which is also influenced by its support. Thus, Sb heterostructure formation is key in 2D Sb integration. Particularly, 2D Sb/graphene interfaces are important. We thus study here few-layered 2D Sb/graphene heterostructures with atomic resolution (scanning) transmission electron microscopy. We find two Sb morphologies to coexist: first, a 2D morphology of layered β-Sb with β-Sb(001)||graphene(001) texture. Second, one-dimensional Sb nanowires which can be matched to β-Sb[2-21]⊥graphene(001) and are closely related to cubic Sb(001)||graphene(001). Importantly, both Sb morphologies show rotational van-der-Waals epitaxy with graphene. Both are resilient against oxidation, although superficial Sb-oxide formation merits consideration, including epitaxial Sb2O3(111)/β-Sb(001) heterostructures. Exact Sb growth behavior depends on processing and substrate properties including, notably, the support underneath the graphene. Our work elucidates the rich phase and epitaxy landscape in 2D Sb and 2D Sb/graphene heterostructures.
Magnetic order and critical temperature of substitutionally doped transition metal dichalcogenide monolayers
Authors: Tiwari Sabyasachi , Van de Put Maarten L. , Sorée Bart , Vandenberghe William G. 
Published: May 2021

AbstractUsing first-principles calculations, we investigate the magnetic order in two-dimensional (2D) transition-metal-dichalcogenide (TMD) monolayers: MoS2, MoSe2, MoTe2, WSe2, and WS2 substitutionally doped with period four transition-metals (Ti, V, Cr, Mn, Fe, Co, Ni). We uncover five distinct magnetically ordered states among the 35 distinct TMD-dopant pairs: the non-magnetic (NM), the ferromagnetic with out-of-plane spin polarization (Z FM), the out-of-plane polarized clustered FMs (clustered Z FM), the in-plane polarized FMs (X–Y FM), and the anti-ferromagnetic (AFM) state. Ni and Ti dopants result in an NM state for all considered TMDs, while Cr dopants result in an anti-ferromagnetically ordered state for all the TMDs. Most remarkably, we find that Fe, Mn, Co, and V result in an FM ordered state for all the TMDs, except for MoTe2. Finally, we show that V-doped MoSe2 and WSe2, and Mn-doped MoS2, are the most suitable candidates for realizing a room-temperature FM at a 16–18% atomic substitution.
Topological vectors as a fingerprinting system for 2D-material flake distributions
Authors: Santos Joyce C. C. , Prado Mariana C. , Morais Helane L. O. , Sousa Samuel M. , Silva-Pinto Elisangela , Cançado Luiz G. , Neves Bernardo R. A. 
Published: May 2021

AbstractThe production of 2D material flakes in large quantities is a rapidly evolving field and a cornerstone for their industrial applicability. Although flake production has advanced in a fast pace, its statistical characterization is somewhat slower, with few examples in the literature which may lack either modelling uniformity and/or physical equivalence to actual flake dimensions. The present work brings a methodology for 2D material flake characterization with a threefold target: (i) propose a set of morphological shape parameters that correctly map to actual and relevant flake dimensions; (ii) find a single distribution function that efficiently describes all these parameter distributions; and (iii) suggest a representation system—topological vectors—that uniquely characterizes the statistical flake morphology within a given distribution. The applicability of such methodology is illustrated via the analysis of tens of thousands flakes of graphene/graphite and talc, which were submitted to different production protocols. The richness of information unveiled by this universal methodology may help the development of necessary standardization procedures for the imminent 2D-materials industry.
Graphene-based 3D XNOR-VRRAM with ternary precision for neuromorphic computing
Authors: Alimkhanuly Batyrbek , Sohn Joon , Chang Ik-Joon , Lee Seunghyun 
Published: May 2021

AbstractRecent studies on neural network quantization have demonstrated a beneficial compromise between accuracy, computation rate, and architecture size. Implementing a 3D Vertical RRAM (VRRAM) array accompanied by device scaling may further improve such networks’ density and energy consumption. Individual device design, optimized interconnects, and careful material selection are key factors determining the overall computation performance. In this work, the impact of replacing conventional devices with microfabricated, graphene-based VRRAM is investigated for circuit and algorithmic levels. By exploiting a sub-nm thin 2D material, the VRRAM array demonstrates an improved read/write margins and read inaccuracy level for the weighted-sum procedure. Moreover, energy consumption is significantly reduced in array programming operations. Finally, an XNOR logic-inspired architecture designed to integrate 1-bit ternary precision synaptic weights into graphene-based VRRAM is introduced. Simulations on VRRAM with metal and graphene word-planes demonstrate 83.5 and 94.1% recognition accuracy, respectively, denoting the importance of material innovation in neuromorphic computing.
High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
Authors: Tran Jenny N. , Günther Oliver P. , Sherwood Karen R. , Fenninger Franz , Allan Lenka L. , Lan James , Sapir-Pichhadze Ruth , Duquesnoy Rene , Claas Frans , Marsh Steven G. E. , McMaster W. Robert , Keown Paul A. ,   Genome Canada Transplant Consortium,   Canada Working Group, Bryan Stirling , Caulfield Timothy , Ragoussis Ioannis , Oualkacha Karim , Tinckam Kathryn , Liwski Robert , Campbell Patricia , Cardinal Heloise , De Serres Sacha A. , Saw Chee Loong , Mengel Michael , Sis Banu , Wagner Eric , Berka Noureddine , McManus Bruce , Hebert Marie-Josée , Foster Leonard J. , Rossi Fabio , Borchers Christoph H. , Piccirillo Ciriaco A. , Polychronakos Constantin , Ng Raymond , Jevnikar Anthony , Cullis Pieter , Filler Guido , Wong Harvey , Foster Bethany , Gill John , Kim S. Joseph , Tibbles Lee Anne , Humar Atul , Shechter Steven , Chaudhury Prosanto , Fernandez Nicolas , Fowler Elizabeth , Kiberd Bryce , Gill Jagbir , Fortin Marie-Chantal , Klarenbach Scott , Balshaw Robert , Mital Seema , Mucsi Istvan , Ostrow David , Stiller Calvin , Parekh Rulan S. , Richard Lucie , Senecal Lynne , Blydt-Hansen Tom ,   United States Working Group, Erlich Henry , Gebel Howard , Weimer Eric , Kaplan Bruce , Burckart Gilbert ,   United Kingdom Working Group, Middleton Derek , Marsh Steven G. E. ,   Netherlands Working Group, Tilanus Marcel , van Gelder Teun ,   Germany Working Group, Opelz Gerhard , Oellerich Michael ,   France Working Group, Marquet Pierre ,   New Zealand Working Group, Marra Carlo ,   Hungary Working Group, Kaló Zoltán 
Published: May 2021

AbstractCompatibility for human leukocyte antigen (HLA) genes between transplant donors and recipients improves graft survival but prospective matching is rarely performed due to the vast heterogeneity of this gene complex. To reduce complexity, we have combined next-generation sequencing and in silico mapping to determine transplant population frequencies and matching probabilities of 150 antibody-binding eplets across all 11 classical HLA genes in 2000 ethnically heterogeneous renal patients and donors. We show that eplets are more common and uniformly distributed between donors and recipients than the respective HLA isoforms. Simulations of targeted eplet matching shows that a high degree of overall compatibility, and perfect identity at the clinically important HLA class II loci, can be obtained within a patient waiting list of approximately 250 subjects. Internal epitope-based allocation is thus feasible for most major renal transplant programs, while regional or national sharing may be required for other solid organs.
G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis
Authors: Boleij Annemarie , Fathi Payam , Dalton William , Park Ben , Wu Xinqun , Huso David , Allen Jawara , Besharati Sepideh , Anders Robert A. , Housseau Franck , Mackenzie Amanda E. , Jenkins Laura , Milligan Graeme. , Wu Shaoguang , Sears Cynthia L. 
Published: May 2021

AbstractG protein-coupled receptor (GPR)35 is highly expressed in the gastro-intestinal tract, predominantly in colon epithelial cells (CEC), and has been associated with inflammatory bowel diseases (IBD), suggesting a role in gastrointestinal inflammation. The enterotoxigenic Bacteroides fragilis (ETBF) toxin (BFT) is an important virulence factor causing gut inflammation in humans and animal models. We identified that BFT signals through GPR35. Blocking GPR35 function in CECs using the GPR35 antagonist ML145, in conjunction with shRNA knock-down and CRISPRcas-mediated knock-out, resulted in reduced CEC-response to BFT as measured by E-cadherin cleavage, beta-arrestin recruitment and IL-8 secretion. Importantly, GPR35 is required for the rapid onset of ETBF-induced colitis in mouse models. GPR35-deficient mice showed reduced death and disease severity compared to wild-type C57Bl6 mice. Our data support a role for GPR35 in the CEC and mucosal response to BFT and underscore the importance of this molecule for sensing ETBF in the colon.