bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of ultrastructural changes in glial cells and nerve fibers of the optic nerve of rats after intra-abdominal injection of a mixture of 40% Ethanol solution and 100% Methanol
Authors: Molchaniuk N.I. 
Published: November 2021

There are, quite often, cases of poisoning of human population with poor-quality alcoholic drinks, which include methanol. The optic nerve, retina and brain tissues are initially affected. A long-term study aimed at identifying initial structural changes in the visual analyzer in the application of various doses of methanol and its mixture with ethanol was carried out. Purpose: to study the dynamics of ultrastructural changes in glial cells and nerve fibers of the optic nerve, which are caused by mixture of ethanol 40% and methanol 100% in a ratio of 3:1 with a dose of methanol of 0.75 g/kg of rat weight. We examined the ultrastructure of the orbit part of the optic nerve of 43 adult rats (Wistar line) in the period from 3 hours to 14 days after one-time intra-abdominal injection of ethanol 40% and methanol 100%, 100% methanol, the dose of methanol is 0.75 g/kg of rat weight. In rats, LD50 is 9.5 g/kg of their weight. It was found out, that within 3 hours after the injection of the mixture of alcohols, the myelin sheath of large-caliber nerve fibers exfoliated, the axoplasm swelled and the mitochondria in their axons pathologically changed, the mitochondria altered in glial cells, which influenced the quality of nerve impulses and axoplasmic transport of substances. In the dynamics of the study, alterative changes in structures of the optic nerve progressed with the complete destruction of part of glial cells by 7 days, mainly in the first 3 days. After the use of methanol 100%, changes in structures of the optic nerve were similar to changes in them after the use of a mixture of alcohols, but with more significant pathology at all periods of observation with the peak of their manifestation on the 7th day. In glial cells and axons of nerve fibers from the 1st day of the study, signs of compensatory and restorative processes were found: they increased protein-synthesizing and energy-forming functions that were aimed at restoring the damaged ultrastructure. It is established, that 3 hours after the injection of a mixture of alcohols, reactive changes in the structures of the optic nerve of rats took place, which from the 1st day develop into pathological changes and are observed up to 14 days with the peak of their activity on the 7th day of the study. After the use of methanol 100%, the ultrastructure of the optic nerve of rats is more damaged than after the injection of a mixture of alcohols. It is proved, that methanol has a leading place in the development of pathological changes in structures of the optic nerve after the injection of a mixture of alcohols.
Discriminant models of the possibility of occurrence and course of psoriasis in men of the general group and different somatotypes depending on the characteristics of anthropo-somatotypological indicators
Authors: Obadeh Bassam Abdel-Rahman Al-Qaraleh , Dmytrenko S.V. , Kyrychenko V.I. , Datsenko G.V. , Gunas V.I. 
Published: November 2021

Significant prevalence and multifactorial occurrence of psoriasis are the main reasons why this disease has been studied for years by scientists in the field of dermatology. Finding tools to predict the occurrence and severity of this disease is one of the key unrealized areas of modern medicine in the field of skin diseases. The purpose of the study is to build and analyze discriminant models of the possibility and features of psoriasis course in Ukrainian men without and taking into account the somatotype, depending on the structure and size of the body. Anthropometric and somatotypological examination of 82 practically healthy and 100 patients with mild and severe psoriasis was performed. Construction of discriminant models of the possibility of occurrence and features of psoriasis depending on anthropo-somatotypological indicators is performed in the license package “Statistica 5.5”. It was found that men of the general group and representatives of the mesomorphic somatotype can reliably interpret the obtained classification indicators both between healthy and patients with psoriasis of different course, and between men with psoriasis of mild and severe course (correctness 84.1% of cases, statistics Wilks’ Lambda=0.074, р<0.001 in the general group, correctness 83.6% of cases, statistics Wilks’ Lambda=0.077, р<0.001 in mesomorphic somatotype). In men of endo-mesomorphic somatotype, a reliable interpretation of the obtained classification indicators is possible only between healthy and psoriatic men (correctness 84.6%, statistics Wilks’ Lambda=0.027, р<0.001). Discriminant models in men of the general group include body diameters and SFT (44.4% each) and the fat component of body weight (11.1% each); in men of mesomorphic somatotype – body diameters (57.1%), SFT (28.6%) and body surface area (14.3%); in men of endo-mesomorphic somatotype – body diameters (60.0%) and SFT on the thigh and the height of the finger anthropometric point (20.0% each). The greatest contribution to discrimination in men of the general group and representatives of the mesomorphic somatotype is made by shoulder width, and in men of endo-mesomorphic somatotype – shoulder width, interspinous and intercristal distances. The results obtained, especially in the division of men into somatotypes, indicate a high genetic predisposition to psoriasis.
The problem of student youth economic socialization: gender perspective
Authors: Kikinezhdi Oksana , Hovorun Tamara 
Published: November 2021

The article deals with the topical issue of personal and professional presentation of young women and men as subjects of their economic socialization. The analysis of the empirical research results of social and psychological determinants of young women and men economic self-presentation, as well as the results of a gender audit is done. A conceptual model of economic behavior of young people in the context of patriarchal / traditional and egalitarian / democratic coordinates is presented. The ambivalence of professional self-realization of young people, in particular, the orientation of girls to economic self-affirmation in the microeconomic environment, and boys - in the macro-society, as well as the commitment of both sexes to traditional gender stereotypes is revealed. The low level of material demands of women, including professional ones, is motivated by the socialized attitude to the financial supremacy of men. In psychological portraits of young men and women who present their professional potential, and hence the economic future, more similarities than differences are observed. Young women show a higher level of subjective general and personal locus of control in professional activities and psychological efforts to defend their beliefs.
The social roles of men and women are still largely mediated by gender stereotypes, which guide the differentiation of their economic self-expression, predetermining the life scenarios declared by the student youth and vision of material commitments. However, the realities of the economic functioning of the genders have shaped the greater personal potential of women in the development of the traditionally masculine economic space, the trigger mechanism for which will dominate the patriarchal egalitarian ideas of personal professional self-presentation. A number of socio-psychological differences between the genders as a consequence of differentiation of their gender socialization should be taken into account in the process of education of economic culture and psychocorrection of professional skills, namely: young women do not concede to men in social, varieties of communicative competence and assertiveness in achieving professional goals.
The development of a market economy aims to increase the inclusion of young people, especially women, in professional entrepreneurship, using the potential of positive psychology. Conducting gender audit as a practical tool in the implementation of quality monitoring of gender sensitivity-insensitivity of economic socialization allows to develop and implement innovative, egalitarian and educational technologies in higher education.
EFFICACY AND SAFETY OF LOW-DOSE HORMONAL THERAPY FOR EPILEPSY IN CHILDREN
Authors: Korotkikh M. , Korotkikh G. 
Published: November 2021

Objective: to evaluate the efficacy and safety of low-dose hormonal therapy of epilepsy in children.
Material and methods: a study was conducted of 32 children aged 3 months to 11 years (21 boys, 11 girls) who received hormone therapy in the lowest clinically effective doses due to the resistance of epileptic seizures to the ongoing therapy with antiepileptic drugs, cognitive, behavioral disorders and regression development. Hormonal preparations were used: tetracosactide (synacthen depot) at a maximum single dose of 0.25-0.5 mg intramuscularly and dexamethasone at a dose of 0.15 mg/kg/day per os. All patients underwent: electroencephalography (EEG) and EEG-video monitoring with the inclusion of sleep, magnetic resonance imaging of the brain, according to indications - tandem mass spectrometry, DNA analysis by clinical sequencing (panel "Inherited epilepsy"), studies aimed at identifying possible side effects of corticosteroid therapy. The duration of follow-up after completion of hormone therapy was 1-4 years.
Research results: a positive result of the therapy was: 1) reduction of epileptiform activity on the EEG, 2) relief of epileptic seizures, 3) restoration (improvement) of impaired higher cortical functions. Long-term positive results were obtained in 62,5% (20/32). The best results were observed in patients with epileptic encephalopathy with continuous spike and wave during sleep, atypical childhood epilepsy with centrotemporal spikes, LandauKleffner syndrome in 100% (8/8). In patients with structural focal epilepsy and continuous spike and wave during sleep, a positive result was achieved in 60% (3/5); in patients with West syndrome, in 57,1% (8/14). A short-term positive result (or lack thereof) was noted mainly in patients with a structure of brain pathology and late initiation of hormone therapy. Side effects were absent or were transient.
Audit System Informasi Absensi Pada PT Multi Engineering Perkasa Dengan Metode Framework Cobit
Authors: Tukino  
Published: November 2021

Abstrak
Perusahaan ini telah memiliki system informasi absensi untuk mencatat kehadiran karyawannya menggunakan mesin sidik jari. Tujuan dari penelitian ini adalah untuk mengukur tingkat kematangan untuk mencari permasalahan yangmuncul dalam proses system informasi absensi untuk memberikan rekomendasi kepada perusahaan untuk memperbaiki manajemen TI yangada. Selama penelitian, penulis menggunakan kerangka kerja COBIT 4.1, dengan fokus pada domain ME, yangterdiri dari subdivisi ME1, ME2, ME3 ME4. Hasil Survei Frekuensi Maturitas System Informasi menggunakan proses-proses yangterdapat pada subsektor ME1 yangmemiliki nilai pembulatan sampai dengan 3, subsektor ME2 yangmemiliki nilai pembulatan sampai dengan 3, ME3. subdomain dengan nilai 3 dibulatkan subdomain ME4 dengan nilai 3 dibulatkan. Pada kematangan TI Level 3, perusahaan harus mengevaluasi setiap proses atau prosedur system; solusi perbaikan harus dilakukan secara konsisten sampai system dalam kondisi optimal. Hasil dari penelitian ini adalah tingkat kematangan TI saat ini (sebagaimana adanya), dengan rata-rata peringkat 3 (proses yangdisetujui), hanya 2 (proses yangdikelola) kematangan domain pemantauan. Deliver, Service Support domain, kemudian Friends hasil kematangan teknologi informasi untuk memberikan saran perbaikan perusahaan. Perusahaan menerima benchmark kematangan TI berdasarkan COBIT 4.1, serta rekomendasi yangdapat diikuti dalam perusahaan untuk perbaikan di masa mendatang.
Abstract
The company already has an attendance information system to record the attendance of its employees through the fingerprint machine. The purpose of this study is to measure the level of maturity to look for problems that arise in the process of attendance information system to make recommendations to companies to improve existing IT management. The authors used the COBIT 4.1 framework in their research, focusing on the ME domain, which consists of ME1, ME2, ME3 ME4 subsectors. The results of the study related to the level of maturity of the attendance information system using the processes contained in sub-sector ME1, which has a value of 3 rounded, sub-sector ME2, which has a value of 3 rounded. , ME3 subdomain, which has a value of 3 rounded ME4 subdomain, which has a value of 3 rounded. solutions must be implemented consistently until the system is in optimal condition. The results of this study are the current level of IT maturity (as it stands), with an average of 3 (approved process) rating, ուղղակի 2 (managed process) maturity of the monitoring domain. For Deliver, Service Support domain. , then, as a result of the maturity of information technologies, the company is given suggestions for improvement. The company receives an IT maturity benchmark based on COBIT 4.1, as well as recommendations that may be followed within the company for future improvements.
Sistem Komunikasi Audio dengan Teknologi Visible Light Communication (VLC) Menggunakan Laser Led
Authors: Charisma Atik , Nur Akbar Setiawan Rizky , Taryana Een , Yuliana Hajiar , Rike Indriani Alifa 
Published: November 2021

Kegiatan masyarakat di era sekarang yang serba digital menggunakan teknologi tanpa kabel (wireless). Teknologi tanpa kabel menjadi andalan komunikasi, namun seiring perkembangann zaman, ada sebuah teknologi tanpa kabel dengan memanfaatkan cahaya tampak. Teknologi ini dikenal dengan istilah visible light communication (VLC). Sistem VLC terdiri dari bagian transmitter dan receiver. Transmitter berupa komponen-komponen elektronika yang terintegrasi dengan cahaya tampak sebagai media transmisi. Pada penelitian ini membuat bagian transmitter dan receiver untuk komunikasi audio. Cahaya tampak sebagai media transmisi menggunakan laser led karena cahaya dari laser led ini lebih fokus dan pancaran cahayanya lebih jauh dibandingkan dengan yang lain. Sedangkan di sisi receiver menggunakan solar panel sebagai penerima sinyal informasi yang dikirimkan. Penelitian ini berhasil membuat sebuah sistem komunikasi audio berbasis visible light communication. Variasi jarak antara transmitter dan receiver mempengaruhi kualitas suara yang diterima. Pada jarak 500 cm kualitas suara yaitu 99,2 dB pada kondisi gelap dan 99,1 dB kondisi terang. Perubahan sudut pancar transmitter terhadap receiver juga mempengaruhi hasil kualitas suara. Kualitas suara terbaik pada sudut 900 di kondisi terang dengan jarak 50 cm sebesar 97,9 dB sedangkan di kondisi gelap dengan jarak 50 cm pada sudut 1000 sebesar 98,1 dB.

Abstract
The people activities in today's digital era use wireless technology. Wireless technology has become the mainstay of communication, but along with the times, there is a wireless technology that uses visible light. This technology is known as visible light communication (VLC). The VLC system consist of transmitter and receiver. Transmitters are electronic components that are integrated with visible light as a transmission medium. In this study, the transmitter and receiver are made for audio communication. Visible light as a transmission medium uses an LED laser because the light from this LED laser is more focused and the light beam is farther away than the others. While on the receiver side using a solar panel as a receiver of the information signal that is sent. This research succeeded in making an audio communication system based on visible light communication. Variations in the distance between the transmitter and receiver affect the quality of the received sound. At a distance of 500 cm in dark conditions, the sound quality is 99.2 dB in light conditions and 99.1 dB. Changes in the beam angle of tranmitter to receiver also affect the sound quality. The best sound quality at an angle of 900 in bright conditions with a distance of 50 cm is 97.9 dB while in dark conditions with a distance of 50 cm at an angle of 1000 is 98.1 dB.
PROGNOSTIC FACTORS AND SURVIVAL IN TRIPLE NEGATIVE AND NON-TRIPLE NEGATIVE BREAST CANCER: EXPERIENCE OF A TERTIARY CARE CANCER CENTER IN ODISHA.
Authors: Parida Prasant Kumar , Samantara Subrat Kumar , Dash Sashibhusan 
Published: November 2021

Background: Because of its high-risk biological features and lack of effective treatment options, triple-negative breast cancer (TNBC) has received greater clinical and experimental interest.

Aim and objectives: The aim of this study was to compare and analyze the clinicopathological features, recurrence, metastasis, and prognosis of patients with TNBC and non-triple negative breast cancer (non-TNBC).

Material and methods: This single hospital-based retrospective study was conducted on patients who were histopathologically diagnosed with breast cancer and subsequently treated from 2017 to 2018 at the Acharya Harihar Postgraduate Institute of Cancer. The clinical features and prognosis of TNBC and non-TNBC were compared.

Results: This study comprised a total of 111 patients, with 36 (32.43%) being TNBC and 75 (67.56%) being non-TNBC. TNBC has 22 patients under the age of 40 (61.1%). Grade III tumors were seen in 47% of TNBC patients and 21% of non-TNBC patients (p-value = 0.05). The disease free survival (DFS) was determined to be 58 % for TNBC and 82% for non-TNBC groups, respectively (p-value = 0.05). These two groups had an overall survival rate (OS) of 72% and 92%, respectively (p-value = 0.05).

Conclusion: When compared to non-TNBC, TNBC was related to high-grade malignancies, worse disease-free survival , and overall survival (OS) rates. Understanding the molecular features of TNBC, clarifying its mechanism at the molecular level, interpreting the gene expression profiles of TNBC, and studying and creating new therapeutic targets should be the focus of future research. To enhance the prognosis of TNBC patients, try to find a focused and effective therapy.

Keywords:
Breast cancer; survival; triple-negative breast cancer.
Аналіз тренувальних програм, розроблених з урахуванням будови тіла спортсменів
Authors: Пітенко С. А. , Лисенко О. М. 
Published: November 2021

Мета. Розробка та експериментальне обґрунтування ефективності тренувальних програм, створених з урахуванням будови тіла спортсменів. Методи. Було проаналізовано засоби тренувальної роботи спортсменів, які займаються бодибілдингом, за допомогою методів антропометрії та каліперометрії. Визначався тип будови тіла за методом Хіт—Картера. Результати. Нами розроблено та доведено ефективність програм тренувальних занять з бодибілдингу з урахуванням будови тіла спортсменів. Після застосування експериментальних програм у спортсменів усіх груп спостерігалося збільшення м’язової тканини, а в ендоморфів – достовірне зниження жирової тканини. Висновки. Дослідження довели, що ефективність тренувального процесу спортсменів, які займаються бодибілдингом, залежить від індивідуальних особливостей будови тіла. Застосовані експериментальні програми тренувальних занять виявилися адекватними для спортсменів з різною будовою тіла.
Адаптаційні резерви системи кровообігу залежно від рівня повсякденної рухової активності молоді
Authors: Дорофєєва О. Є. , Коршак В. М. , Яримбаш К. С. 
Published: November 2021

Мета. Визначити взаємозв’язок між рівнем повсякденної рухової активності, адаптаційними резервами системи кровообігу та частотою захворюваності студентської молоді для формування мотивації підвищення рівня фізичної підготовленості, запобігання розвитку патологічних процесів в організмі та покращення якості життя студентів. Методи: аналіз наукової та науково-методичної літератури, спостереження, бесіда, анкетування, тестування. Результати. Переважна кількість студентів займаються фізичною культурою менше ніж три години на тиждень або не займаються взагалі, що позначається на частоті їх захворюваності на ГРВІ протягом року, а також супроводжується хронічними змінами в роботі серцево-судинної, дихальної і травної систем. Функціональна рухливість системи кровообігу у фізично активної молоді значно досконаліша: дозоване фізичне навантаження у них забезпечується меншою активізацією хронотропного і більшою – інотропного резерву серця. Висновки. Своєчасна об’єктивізація функціональних змін в організмі молоді дозволяє вирішити проблеми профілактичних заходів, а діагностика функціональних резервів системи кровообігу може бути здійснена простими і доступними для масових обстежень функціональними пробами; проблема адаптаційних резервів системи кровообігу молоді залежно від повсякденної рухової активності потребує подальшого вивчення для мотивації до більш активного способу життя сучасної молоді.
IMPLEMENTATION OF MULTIPLE INTELLIGENCE DEVELOPMENT METHOD IN FIQH LEARNING IN MADRASAH TSANAWIYAH (MTs)
Authors: Shidiq Sapiudin , Nasuki Ahmad 
Published: November 2021

Method of applying contemporary fiqh learning is still conventional. This research has purpose to describe method of applying fiqh learning effectiveness in MTs. This research uses a qualitative-descriptive and naturalistic approach by means of interview, observation and documentation instrument. By means of triangulation of data collection and tabulation technique, obtained a research outcome that implementation of fiqh learning method in MTs Pembangunan UIN Jakarta is proportionally considered effective in developing the students multiple intelligence. This is proofed by some implementations of learning method. 1). Movie learning method is effective for student who has talent of music, linguistic and visual-spatial intelligence, 2). Question-answer method is effective for student who has talent of math and logic, 3). Demonstration is effective for student who has talent of kinesthetic-bodily and interpersonal intelligence, 4). Concept chart method is effective for student who has talent of visual-spatial and intrapersonal intelligence. This research can be a model of method application in fiqh learning at MTs.