bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Traditional Knowledge About Herbal Use In Veterinary Medicine At The Balkan Peninsula
Authors: Radoslava Savić Radovanović R. , Biljana Andjelski Radičević H. , Nataša Rajić Savić S. , Nemanja Zdravković , Ivan Pavlović N. , Dragan Ilić V. 
Published: July 2021

Abstract
Background. The traditional knowledge about herbal use in veterinary medicine in Serbs is voluminous. However, that wealth is threatened to oblivion because new times give modern methods of treatment. Hence, the aim of this report was to present the collected data about folk methods of treatment and nutrition by the help of available plants related to the animals in Serbs what could be applied in up to date veterinary pharmacy. Methods. The questionnaire of 28 questions was prepared regarding the breeding, nutrition and medical treatment of domestic animals as well as the herbal list of medicinal plants to use. The study is based on the ”Show-and-Tell Technique” from the groups people without veterinary or medical education, with preference to people living in the remote settlements without resident veterinary services. Results. Interviewed persons were in the age range of 30-90 years. Plant interviewee were asked to show the plant species in a fresh or dried condition (for adequate identification). The 1120 filled inquiry sheets were analysed. Ninety two herbs were presented, of whom the most frequent noted were Carlina acaulis, Asteraceae (6 times) and Geum urbanum, Rosaceae (5 times). The most frequent treated diseases were of digestive (47%) and pulmonary system (25%), skin (hair, hoof) (8%) and urinary system (7%). Among “other” cathegory answers like “generaly good for helath” are included. Conclusion. It is still open question for the scientific branches of veterinary pharmacology to find out active ingredients, mechanism of action and application of some plants in the scope of veterinary pharmacology, phytochemistry and phytopharmacology. In that way the listed herbs in this work, which are still not in use nowadays, could be recognized as commercially available.
Longitudinal Study of Psychological Status during the COVID-19 Pandemic
Authors: Okuyama Junko , Seto Shuji , Fukuda Yu , Taku Kanako , Willgerodt Mayumi , Ito Kiyoshi , Imamura Fumihiko , Izumi Shinichi 
Published: July 2021

Abstract
Researchers believe that the impact of repeated trauma on mental health is incrementally more significant than the simple additive effect of one event. This study questioned whether this repetition only further worsens people's mental health. We found that they may report more positive changes than those who haven’t. Thus, we hypothesized that repeatedly experiencing difficult situations and suffering might increase post-traumatic growth (PTG). PTG can be defined as "positive psychological changes experienced due to coping with very difficult life situations," leading to positive outcomes and feelings of well-being. We found that those who experienced a disaster in the past were more depressed, anxious, and stressed than those who had never experienced a disaster and now experienced the COVID-19 pandemic. Additionally, past disaster experience led to a more psychological response to the COVID-19 pandemic, which, in turn, led to an increase PTG. Globally, we found that supportive social interactions, including those with family members, could develop PTG during the COVID-19 pandemic and achieve better well-being during the continuation of the pandemic in the future.
Implementation of Innovative Medical Technologies In German Inpatient Care: Patterns of Utilization And Evidence Development
Authors: Böcker Marie , Eckhardt Helene , Felgner Susanne , Errmann Hanna , Lantzsch Hendrikje , Rombey Tanja , Busse Reinhard , Henschke Cornelia , Panteli Dimitra 
Published: July 2021

Abstract
Background: Innovative medical technologies are commonly associated with positive expectations. At the time of their introduction into care, there is often little evidence available on their benefits and harms. Thus, it happens that some health innovations with a lack of evidence are used widely until or even though adverse study results emerge. Others with strong scientific support remain underused. The study aims at examining the diffusion patterns of innovative medical technologies in German inpatient care between 2005 and 2017 while simultaneously considering evidence development. Methods: Based on a qualitatively derived typology and a quantitative clustering process of the adoption curves, a representative sample of 21 technologies was selected for further evaluation. Published scientific evidence on efficacy and safety of the technologies was identified and extracted in a systematic approach. Derived from a two-dimensional classification according to the degree of utilization and state of scientific evidence, the diffusion processes were then assigned to the categories "Success" (widespread/positive), "Hazard" (widespread/negative), "Overadoption" (widespread/limited or no), "Underadoption" (cautious/positive), "Vigilance" (cautious/negative) and "Prudence" (cautious/ limited or no). Results: Overall, we found limited evidence regarding both the quantity and quality of published randomized controlled trials. Thus, the categories “Prudence” and “Overadoption” together account for nearly three-quarters of the years evaluated, followed by “Success” with 17 percent. Even when evidence is available, the transfer of knowledge into practice seems inhibited.Conclusions: The successful implementation of innovations into practice requires substantial further efforts by policymakers to strengthen systematic knowledge generation and translation. Creating an environment that encourages the conduct of rigorous studies, promotes knowledge translation, and rewards innovations according to their added value are prerequisites for the diffusion of valuable innovations in the health care sector.
Effects Of Exercise Training On Blood Pressure: Protocol For An Overview Of Systematic Reviews
Authors: Loaiza-Betancur Andrés F , Bedoya Edison Andrés Pérez , Díaz-López Víctor Alfonso , Echavarría-Rodríguez Andrés Mauricio , Chulvi-Medrano Iván , Gonzáles Lisette Ethel Iglesias , Meneses-Echavez Jose F 
Published: July 2021

Abstract
Background
This overview aims to identify, appraise, and summarize the findings of all relevant systematic reviews about the benefits and harms of different exercise training modalities on blood pressure in normotensive, pre-hypertensive, and high blood pressure adults.
Methods
This overview of systematic reviews protocol was reported following the PRISMA-P Statement. We will search MEDLINE, EMBASE, and Epistemonikos to identify systematic reviews of randomized controlled trials (RCTs) in adults with or without a diagnosis of high blood pressure that compared exercise training interventions with other or no exercise interventions. Major outcomes will be blood pressure and adverse events. Pairs of reviewers will independently screen the systematic reviews for inclusion, extract data, and appraise the methodological quality. The GRADE approach will be used to evaluate the quality of the evidence.
Discussion
Findings from this study will contribute to the knowledge base in the area by providing a systematic synthesis of the certainty of the evidence for the effects of the different training modalities on blood pressure. These assessments might also assist in both the development of clinical practice guidelines and to strengthen evidence-informed decision making in healthcare. Finally, this study might serve to inform patients, caregivers, healthcare providers, researchers, and decision-makers about the benefits and adverse events related to different exercise training modalities, as well as the knowledge gaps in the body of evidence.
Protocol registration:
PROSPERO CRD42021247062
A Deep Neural Network-based Nonlinear Dynamics Model for the Prediction of Lateral-longitudinal Vehicle Dynamics
Authors: Pan Yongjun , Nie Xiaobo , Dai Wei , Xu Feng , Li Zhixiong 
Published: July 2021

Abstract
The vehicle multibody model can be used for accurate coupling dynamics, but it has higher computational complexity. Numerical stability during integration is also very challenging, especially in complicated driving situations. This issue can be substantially alleviated by using a data-driven nonlinear dynamics model owing to its computational speed and robust generalization. In this work, we propose a deep neural network (DNN)-based modeling approach for predicting lateral-longitudinal vehicle dynamics. Dynamic simulations of vehicle systems are performed based on a semirecursive multibody formulation for data acquisition. The data are then used for training and testing the DNN model. The DNN inputs are the torque applied on wheels and the initial vehicle speed that imitates a double lane change maneuver with acceleration and deceleration. The DNN outputs are the longitudinal driving distance, lateral driving distance, final longitudinal velocities, final lateral velocities, and yaw angle. The dynamic responses obtained from the DNN model are compared with the multibody results. Furthermore, the accuracy of the DNN model is investigated in terms of error functions. The DNN model is finally verified via the results of a commercial software package. The results show that the DNN vehicle dynamics model predicts accurate dynamic responses in real time. The DNN model can be used for real-time simulation and preview control in autonomous vehicles.
Dialectical Behavior Therapy Skills Training as a Standalone Therapy: a Scoping Review Protocol
Authors: Thorsteinson Branden , Husarewycz M. Natalie , Loewen Hal , Thiessen Maclean 
Published: July 2021

Abstract
Background: Dialectical Behavior Therapy (DBT) Skills Training (DBT-ST) is one of the four core elements of standard DBT. Studies show that standalone DBT-ST appears to be a promising treatment in patients with emotion dysregulation by teaching them skills needed to change patterns associated with problems in living. It is not clear who benefits from this treatment and which components are most beneficial. Relevant studies will be easily navigated once mapped and summarized in this proposed scoping review.Methods:The proposed scoping review will be conducted following Joanna Briggs Institute (JBI) methodology for scoping reviews. Medical literature databases including MEDLINE, PsycINFO, EMBASE, CINAHL, SCOPUS, Web of Science, and Cochrane will be searched. Papers retrieved will be screened for inclusion by two independent reviewers and data will be extracted and reported in a summary table with supporting narrative. We aim to include all English academic papers addressing standalone DBT-ST including studies utilizing quantitative, qualitative, and mixed methods approaches. Discussion:The objective of this scoping review is to explore the literature, map, and summarize evidence pertaining to DBT-ST to help guide future research and treatment.
Impact of Vaccination on the COVID-19 Pandemic: Evidence from U.S. States
Authors: Chen Xiao , Huang Hanwei , Ju Jiandong , Sun Ruoyan , Zhang Jialiang 
Published: July 2021

Abstract
Governments worldwide are implementing mass vaccination programs in an effort to end the novel coronavirus (COVID-19) pandemic. Here, we evaluated the effectiveness of the COVID-19 vaccination program and predicted the path to herd immunity in the U.S. We estimated that vaccination reduced the total number of new cases by 4.4 million (from 33.0 to 28.6 million), prevented approximately 0.12 million hospitalizations (from 0.89 to 0.78 million), and decreased the population infection rate by 1.34 percentage points (from 10.10–8.76%). We built a Susceptible-Infected-Recovered (SIR) model with vaccination to predict herd immunity. Our model predicts that the U.S. can achieve herd immunity by the last week of July 2021, with a cumulative vaccination coverage of 60.2%. Herd immunity could be achieved earlier with a faster vaccination pace, lower vaccine hesitancy, and higher vaccine effectiveness. These findings improve our understanding of the COVID-19 vaccination and can inform future public health policies.
The Management of Anticoagulants in Patients With Atrial Fibrillation and History of Falls or Risk of Falls: The Liverpool Af-falls Project. Protocol for a Systematic Review and Meta-analysis
Authors: Galvain Thibaut , Hill Ruaraidh , Donegan Sarah , Lisboa Paulo , Lip Gregory Y. H. , Czanner Gabriela 
Published: July 2021

Abstract
BackgroundAtrial fibrillation affects an estimated 33 million individuals worldwide and is a major cause of stroke, heart failure, and death. Anticoagulants substantially reduces risk of stroke but are also associated with an increased risk of bleeding and especially intracranial hemorrhages which are the most feared complication. Because of this many patients are not offered anticoagulants, particularly patients at risk of falls or with history of falls. It is unclear what anticoagulant treatment these patients should be offered, and the Liverpool AF-Falls project aims to investigate this area. This protocol for a systematic review and meta-analysis aims to define what is the most appropriate anticoagulant treatment option for the for the management of atrial fibrillation patients at risk of falls or with a history of falls. MethodsThis systematic review and meta-analysis will include randomized and non-randomized studies evaluating safety and efficacy of different anticoagulant treatments (vitamin K antagonist, non-vitamin K antagonist oral anti-coagulant, anti-platelet agent and no treatment). Bibliographic databases (Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Scopus, CINAHL, Web of Science and ClinicalTrials.gov) will be searched according to a pre-specified search strategy. Titles, abstracts, and full texts will be assessed by two independent reviewers and disagreement resolved with a third independent reviewer. The Cochrane Risk of Bias tool 2 will be used to assess risk of bias in randomized trials and the Newcastle-Ottawa-Scale tool will be used for non-randomized studies. Pairwise meta-analysis based on the fixed and random-effects models will be conducted. Publication bias will be evaluated with a funnel plot and the Egger’s test. Heterogeneity will be assessed with the I2 statistic. If conditions for indirect comparison are met and sufficient data are available, a network meta-analysis will be conducted using frequentist and Bayesian methodologies. DiscussionThis review will be the first to summarize direct and indirect evidence on safety and efficacy of anticoagulant treatments in atrial fibrillation patients at risk of falls or with history of falls. The findings will be important to patients, clinicians, and health policy-makers to inform best practice in the use of these treatments. Systematic review registrationPROSPERO registry number: CRD42020201086
Measurement of Heterogeneity From 18F-FDG PET For Classification of Metastatic And Benign Bone Lesions: A Study In Patients With Cervical Cancer
Authors: Liu Feng-Yuan , Lin Gigin , Tseng Jing-Ren , Chao Angel , Huang Huei-Jean , Chou Hung-Hsueh , Chang Yu-Chen , Yen Tzu-Chen , Lai Chyong-Huey 
Published: July 2021

Abstract
Purpose Heterogeneity assessment has been applied in medical imaging analysis. We aim to evaluate first-order and texture analysis (TA) metrics in 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging for classification of metastatic and benign bone lesions in patients with cervical cancer.Materials and Methods: 18F-FDG PET studies for cervical cancer patients performed on a specific PET/CT system from 2016 to 2018 were retrieved. Bone lesions extracted from studies in 2016-2017 were used as the training dataset and those in 2018 as the validation dataset. Metastatic bone lesions were identified in each dataset, with an equal number of benign bone lesions selected. Cuboid volume of interest (VOI) consisting of 3 by 3 by 5 reconstructed voxels was defined for first-order metrics and cubic VOI consisting of smaller voxels with trilinear interpolation of standardized uptake value (SUV) was adopted for TA metrics. First-order metrics included maximum SUV (SUVmax) of lesion and mean, standard deviation (SUVsd), skewness and kurtosis of voxel SUV in VOI. A total of 4464 TA metrics based on 62 texture features were evaluated. Logistic regression was used for classification with area under the receiver operating characteristic curve (AUC) as the performance measure.Results: From the training and validation datasets, 98 and 42 metastatic bone lesions were identified respectively. SUVsd achieves a better performance than SUVmax in both training (AUC .798 vs .732, P < .001) and validation (AUC .786 vs .684, P < .001) datasets. Top-performing TA metrics achieved significantly better performance in the training dataset but failed to retain this advantage in the validation dataset.Conclusion: This study identified a simple first-order measure of heterogeneity, SUVsd, to be superior to SUVmax in the classification of metastatic and benign bone lesions. The effect of multiple hypothesis testing can result in false-positive findings in TA with multiple features and parameters and careful validation is needed.
Enhancing Leadership, Management, And Governance Competencies For Performance Improvements At Primary Health Care Entities In Ethiopia: A Before And After Study
Authors: Desta Binyam Fekadu , Muktar Sualiha Abdlkader , Abera Wondwosen Shiferaw , Demissie Heran , Argaw Mesele Damte 
Published: July 2021

Abstract
ObjectivesLeadership, management, and governance (LMG) interventions play a significant role in improving management systems, enhancing work climate, and creating responsive health systems. This study aimed to determine the change that occur in the performance of primary healthcare entities and compare the outputs of block and segmented LMG trainings and the intervention as a whole after implementation for one full year.ResultsTwo hundred and ninety-three LMG trained and 333 non-trained health workers participated with a response rate of 100 percent and 87 percent, respectively. Of those who attended the didactics sessions, 235 (80.9%) scored 70% or more on post-test exams. In addition, the assessment on the practical exercises after implementing the leadership projects revealed that the majority, 252 (86%) scored 80% or more on their desired measurable results. As a result of the LMG trainings, management systems, work climate, and responsiveness of the health system to new challenges were significantly improved (p<0.001). Owing to the leadership projects, within the 136 health facilities, an additional 2,290.3 units of health service coverage was gained. A comparison of the trainees revealed that more block (79.1%), than segmented I (65.02%) and segmented II (62.0%) LMG trainings were successfully completed. Therefore, providing block LMG trainings for more health workers and managers working at primary healthcare entities is 53 recommended as it willaccelera te the implementation of prioritized health sector interventions.
Implementation Factors Related to Improving the Food Environment Within Health Care Institutions: A Multiple Case Study
Authors: Walker Elizaveta , Baker Robin L , O'Brien Kerth , Messer Lynne C , Eckhardt Cara L , Goodman Julia M 
Published: July 2021

Abstract
Background Healthy food environment policies (HFEPs), such as sugar-sweetened beverage bans or nutritional standards for vending machines, can improve the healthfulness of retail food venues, particularly within health care institutions that have a health-focused mission. The degree to which operational managers’ and executive leaders’ perceptions of implementation challenges align or diverge, and the extent to which these perceptions affect HFEP implementation, is unknown.Methods We conducted ten semi-structured key informant interviews with managers and executive leaders who participated in HFEP development within five health care organizations. Interviews explored facilitators and barriers for HFEP adoption and maintenance. We transcribed, coded, and analyzed interviews and derived contextual facilitators and barriers.Results We identified 27 facilitators and 30 barriers, which were refined into six and five categories, respectively, and ultimately paired to create three overarching recommendations. Operational managers’ and executive leaders’ perceptions overlapped 44-75% when identifying facilitators but only 33-58% when identifying implementation barriers. Interpersonal issues such as over-delegation and mistrust were prominent among those organizations whose respondents’ perceptions diverged substantially.Conclusion As the obesity epidemic continues to increase, understanding key facilitators and barriers to HFEPs, as well as the influence on leaderships’ perceptions on the implementation process, will be key to addressing obesogenic food environments. Though leaders were generally aligned in perspectives regarding facilitators, there was greater divergence when barriers were discussed. Executive leaders are encouraged to familiarize themselves with operational barriers and refrain from over-delegating these challenges to their operational counterparts, who lack the institutional authority to override organizational or system-level decisions.
Serial Histological Changes in the Cartilaginous Eustachian Tube in the Rat Following Balloon Dilation
Authors: Kim Yehree , Kang Jeon Min , Ryu Dae Sung , Park Jung-Hoon , Kang Woo Seok , Park Hong Ju 
Published: July 2021

Abstract
Although balloon dilation has shown promising results in the treatment of dilatory Eustachian tube (ET) dysfunction, the histological effects of ET balloon dilation (ETBD) remain unclear. We evaluated this in a rat model. The left ET of 20 Wistar rats was dilated with a balloon catheter and the right ET was used as a control. Five rats were sacrificed immediately after ETBD, at 1, 4 and 12 weeks after the procedure for histological examination. The epithelial cells, presence of squamous metaplasia, and the proportion of the goblet cells in the epithelium; the vascular structures and dimensions of the submucosa; and presence of cartilage fracture and the area of the ET lumen were evaluated and compared between the groups. Desquamation of nearly all epithelial cells and the fracture of tubal cartilages were observed immediately after ETBD. At 1-week post-ETBD, the ciliated epithelial cells started to recover with squamous metaplasia and epithelial hyperplasia. The goblet cells recovered by 4 weeks post-ETBD and epithelial hyperplasia decreased but was still present at 12 weeks post-ETBD. The depth of the submucosa increased and neovascularization in this region was observed at 1-week post-ETBD and persisted up to 12 weeks post-ETBD. The lumen of the cartilaginous ET increased immediately after ETBD but decreased at 1-week post-ETBD. The cartilaginous ET lumen recovered to the normal value at 4 weeks post-ETBD. This study is the first to describe the serial histological changes to the cartilaginous ET after ETBD and helps our understanding of the histological changes that occur after an ETBD intervention for intractable ET dysfunction.