bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parthenius, Erotica Pathemata 26 e la storiografia locale milesia. Riflessioni sulle annotazioni al codice Palatinus Heidelbergensis gr. 398
Authors: Polito Marina 
Published: December 2024

ABSTRACT Parthenius, Erotica Pathemata 26 and the local Milesian historiography. Considerations on the annotations to the codex Palatinus Heidelbergensis gr. 398 This paper consists of an examination of some main aspects and problems of the notes that the Codex Pal. gr. 398 preserves on Parthenius’ Erotika Pathemata. It further systematically examines some characteristic features of the annotation work with the aim of a historiographical reading of the phenomenon. This contribution mainly examines the notes of Pathema 26 (f. 186r), the features of which might allow us to shed light on the annotations in their genesis and contribute to the understanding of at least some aspects of fragments of local historiography traceable in the notes.
Risk of Cancer After Initiation of Targeted Therapies in Patients With Rheumatoid Arthritis and a Prior Cancer: Systematic Review With Meta‐Analysis
Authors: Wetzman Amélie , Lukas Cédric , Gaujoux‐Viala Cécile , Mamtani Ronac , Barnetche Thomas , Combe Bernard , Morel Jacques , Szafors Paulina 
Published: September 2021

ObjectiveTo determine the risk of recurrent or new malignancy with exposure to targeted disease‐modifying antirheumatic drugs (DMARDs) in adults with rheumatoid arthritis (RA), axial spondyloarthritis (SpA), or psoriatic arthritis (PsA) and a history of cancer.MethodsWe performed a systematic search of the literature for articles published up to June 2019 that investigated adults with RA, axial SpA, or PsA who had a history of cancer and received biologic or targeted synthetic DMARDs (bDMARDs or tsDMARDs). We compared the risk of relapse or occurrence of new cancer between patients with and without bDMARDs. Rate ratios (RRs) with 95% confidence intervals (95% CIs) were estimated. The heterogeneity of the studies was evaluated by the Cochran Q test and the I2 statistic.ResultsWe included 24 observational studies of chronic inflammatory arthritis; of those, 12 were included in the meta‐analysis of RA patients receiving bDMARDs. As compared with RA patients with a history of cancer and not receiving bDMARDs, for those receiving any bDMARD, the overall RR for risk of neoplasia was 1.09 (95% CI 0.92–1.32; P = 0.31, I2 = 8%); with tumor necrosis factor inhibitors, it was 1.11 (95% CI 0.85–1.46; P = 0.45, I2 = 48%); and with rituximab, it was 0.79 (95% CI 0.41–1.53; P = 0.49, I2 = 0%). The RR for risk of recurrence for skin cancer was 1.32 (95% CI 1.02–1.72; P = 0.04, I2 = 0%) and for breast neoplasia 1.21 (95% CI 0.84–1.72; P = 0.31, I2 = 0%).ConclusionApart from skin cancers including melanoma, the risk of recurrent or new cancer is not increased with the initiation of bDMARDs for RA as compared with no bDMARDs.
Motivators, Barriers, and Opportunity for E‐Health to Encourage Physical Activity in Axial Spondyloarthritis: A Qualitative Descriptive Study
Authors: Passalent Laura , Cyr Alaina , Jurisica Igor , Mathur Sunita , Inman Robert D. , Haroon Nigil 
Published: September 2021

ObjectivePhysical activity is fundamental in the management of axial spondyloarthritis (SpA); however, evidence suggests that patients with axial SpA are not adhering to physical activity recommendations. E‐health technology (e.g., telephone reminders and mobile text messaging) can increase participation in physical activity. The aims of this study were as follows: 1) to understand perspectives of the importance of physical activity in the management of axial SpA; 2) to describe factors associated with physical activity adherence; and 3) to explore the role of e‐health technology to facilitate physical activity in patients with axial SpA.MethodsSemistructured interviews were conducted with axial SpA patients attending an urban academic rheumatology clinic. Interviews were audio recorded and transcribed verbatim. Data were analyzed using thematic principles. Systematic labeling of the data set was completed using an inductive approach until saturation of emergent themes.ResultsTwelve patient interviews were completed. Most respondents were male (83.3%) with a mean ± SD age of 45.5 ± 12.5 years and a mean ± SD disease duration of 21.5 ± 14.9 years. Participants defined physical as any activity involving physical exertion. The role of physical activity in axial SpA management was well recognized and included symptom relief, pharmacologic synergy, and impact on general health. Motivators included a growth mindset, social support networks, and facility access. Barriers included fear of disease progression, life demands, and environmental restrictions. Feedback, electronic reminders, and virtual support networks were key components of e‐health technology to facilitate engagement in physical activity.ConclusionThe results of this study provide a foundation to guide development of patient‐centered e‐health technology interventions to increase physical activity uptake in patients with axial SpA.
Factors Associated With Variation in Pediatric Systemic Lupus Erythematosus Care Delivery
Authors: Burnham Jon M. , Cecere Lynsey , Ukaigwe Joy , Knight Andrea , Peterson Rosemary , Chang Joyce C. 
Published: September 2021

ObjectivePatients with pediatric systemic lupus erythematosus (pSLE) and mixed connective tissue disease (MCTD) receive only a fraction of recommended care. Using published quality indicators and guidelines, we developed a 13‐item pediatric lupus care index (p‐LuCI) to quantify the proportion of recommended clinical evaluations and comorbidity prevention interventions completed and the timeliness of follow‐up. Our objective was to assess baseline index performance and identify sources of p‐LuCI variation.MethodsWe performed a cross‐sectional study in patients with pSLE or MCTD and analyzed the performance of individual p‐LuCI process metrics and calculated the overall p‐LuCI score. We identified factors associated with the p‐LuCI using multivariable linear regression with clustering by provider.ResultsFor 110 patients (99 with pSLE and 11 with MCTD), the median p‐LuCI was 65.2% (interquartile range: 9.1‐92.3%). Component performance ranged from 27.3% (on‐time scheduling) to 95.4% (steroid‐sparing treatment). Patients with p‐LuCI scores above the median had higher scores across all 13 components. Higher p‐LuCI scores were independently associated with disease‐modifying antirheumatic drug use (β = 14.3 [95% confidence interval (CI), 1.5‐27.2]), nephritis (β = 10.4 [95% CI, 5.1‐15.8]), higher provider pSLE/MCTD volume (β = 3.1 [95% CI, 1.9‐4.2] per patient), assignment to rheumatology fellow trainee (β = 36.3 [95% CI, 17.3‐55.2]), and disease duration of less than 1 year (β = 12.6 [95% CI, 0.7‐24.5]). Differences by race, ethnicity, and/or insurance were not observed.ConclusionUsing an index of recommended pSLE care metrics, we identified significant variation in performance by disease, treatment, and provider characteristics. The p‐LuCI may be useful to assess care quality at the patient, provider, and practice levels and to identify areas in need of greater standardization.
Molecular Design of Ultrabright Semiconducting Polymer Dots with High NIR‐II Fluorescence for 3D Tumor Mapping
Authors: Li Yi‐Xuan , Su Shih‐Po , Yang Chou‐Hsun , Liu Ming‐Ho , Lo Pin‐Ho , Chen Yi‐Chen , Hsu Chao‐Ping , Lee Yi‐Jang , Chiang Huihua Kenny , Chan Yang‐Hsiang 
Published: September 2021

AbstractFluorescence probes emitting in the second near‐infrared (NIR‐II, 1000–1700 nm) window with the ability for deep‐tissue imaging in mammals herald a new era in surgical methodology. However, the brightness of these NIR‐II probes is still far from satisfactory due to their low fluorescence quantum yields (QYs), preventing the observation of high‐resolution images such as whole‐organ vascular networks in real time. Described here is the molecular engineering of a series of semiconducting polymer dots (Pdots) incorporated with aggregation‐induced emission moieties to exhibit the QYs as high as 14% in the NIR‐II window. Benefiting from the ultrahigh brightness, a 1400 nm long‐pass filter is utilized to realize in vivo 3D tumor mapping in mice. To further understand how the geometrical and electron structures of the semiconducting polymers affect their optical properties, the in‐depth and thorough density‐functional theory calculations are performed to interpret the experimental results. This study lays the groundwork for further molecular design of highly bright NIR‐II Pdots.
Tuning Vertical Electron Transfer on Graphene Bilayer Electrochemical Devices
Authors: Sanches Natalia M. , Hassan Ayaz , Mattioli Isabela A. , Macedo Lucyano J. A. , Sedenho Graziela C. , Crespilho Frank N. 
Published: September 2021

AbstractPristine graphene electrodes exhibit slow vertical (off‐plane) heterogeneous electron transfer (HET) rate that limits their application in electrochemical devices. This can be minimized by generating defects in the graphene structure. However, these defects adversely affect the horizontal (in‐plane) electrical conductivity characteristic to graphene. Here, the fabrication of graphene bilayer devices with modulated vertical HET is reported. Strategically, the upper sheet is used as a sacrificial layer for the introduction of extrinsic defects via electrochemical oxidation while preserving the structure of the graphene underlying layer. For [Fe(CN)6]4−/[Fe(CN)6]3− vertical HET in solution‐phase, oxidized electrodes present a very low charge transfer resistance. For vertical HET in surface adsorbed ferrocene on oxidized electrodes, the vertical HET rate constant is about five times higher than on pristine electrodes. Based on data from scattering‐type scanning near‐field optical microscopy (s‐SNOM) and Raman spectroscopy, the improvement on the electrochemical properties is attributed to the defects that are incorporated in the upper layer graphene lattice. This fundamental study on the atomic behavior of defects and stacking layers of graphene provides a new strategic design of graphene‐based devices with superior electrochemical performance.
Morphological characterization of the foliar surface in glyphosate‐resistant tall windmill grass
Authors: Placido H. F. , Santos R. F. , Oliveira Júnior R. S. , Marco L. R. , Silva A. F. M. , Barroso A. A. M. , Albrecht A. J. P. , Victoria Filho R. 
Published: September 2021

AbstractEven though glyphosate resistance in tall windmill grass (Chloris elata Desv.) was initially reported in 2014, the resistance mechanisms have not yet been completely elucidated. Previous research found evidence of a non‐target site mechanism limiting the herbicide from reaching its enzyme target. We investigated the foliar morphology of tall windmill grass biotypes at different leaf developmental stages and correlated these results with glyphosate‐resistance levels. The biotypes were sprayed with glyphosate and their foliar anatomy was characterized at the four‐ to six‐leaf stages using scanning electronic microscopy. Samples were analyzed for stomata and trichome density and stomatal index was calculated. The resistant tall windmill grass biotype showed lower stomatal density at the four‐leaf stage and greater trichome density at the four‐ and six‐leaf stages, compared to the susceptible biotype, which might contribute to less herbicide uptake. Both biotypes had wax crystal formations surrounding the stomatal pore in plants at the six‐leaf stage, which could also contribute to the lower glyphosate susceptibility in older plants.
HybridPDE‐kMCmodeling approach to simulate multivalent lectin‐glycan binding process
Authors: Lee Dongheon , Green Aaron , Wu Hung‐Jen , Kwon Joseph Sang‐Il 
Published: September 2021

AbstractGlycans are the major components of the cellular membranes and mediate many cellular processes via their interactions with lectins. A kinetic Monte Carlo (kMC) model was proposed previously to incorporate the key features of glycan‐lectin interactions such as multivalency and glycan diffusion, and its accuracy has been validated by experiments. However, computational cost of the kMC model is its major bottleneck. In this study, a hybrid model combining a partial differential equation (PDE) with the kMC model is proposed to greatly reduce the computational cost while preserving the accuracy. Specifically, glycan diffusion is simulated by the PDE for improving computational efficiency since the glycan diffusion execution through the kMC is computationally expensive. The hybrid PDE‐kMC model is employed to simulate the binding dynamics between cholera toxin subunit B and gangliosides on cellular membranes. The accuracy and efficiency of the proposed model was demonstrated by comparing with the sole kMC model.
Heteroleptic Palladium(II) Complexes of Thiazolinyl‐picolinamide Derived N∩N∩N Pincer Ligand: An Efficient Catalyst for Acylative Suzuki Coupling Reactions
Authors: Sudharsan Murugesan , Nethaji Munirathinam , Bhuvanesh Nattamai S. , Suresh Devarajan 
Published: September 2021

AbstractSynthesis, reactivity, characterization, and catalytic activities of a series of palladium(II) complexes containing the thiazolinyl‐picolinamide derived pincer ligand is reported. Treatment of 2‐aminobenzonitrile with cysteamine and subsequent treatment with 2‐picolinic acid afforded the thiazolinyl‐picolinamide derived tridentate pincer ligand N∩N∩N (2). Treatment of 2 either with (COD)PdCl2 or PdCl2 in 1 : 1 ratio afforded the palladium(II) complex [(κ3‐N∩N∩N)PdCl] (3). A reaction between Pd(OAc)2 and 2 in equimolar ratio in dichloromethane gave [(κ3‐N∩N∩N)Pd(η1‐OAc)] (4) which on further treatment with triflic acid in acetonitrile produced the [(κ3‐N∩N∩N)Pd(N≡C−CH3)]OTf (5). The complex 5 was further treated with auxiliary ligands to produce the cationic heteroleptic palladium complexes, [(κ3‐N∩N∩N)Pd(NC5H5)]OTf (6), [(κ3‐N∩N∩N)Pd(NC5H4CN)]OTf (7), and [(κ3‐N∩N∩N)Pd(NC5H4NMe2)]OTf (8), respectively. The newly synthesized compounds were characterized by 1H and 13C{1H} NMR spectroscopic techniques and the molecular structures of 2–4, 6 and 8 were established. The catalytic activity of palladium(II) complexes (3–8) were evaluated for the acylative Suzuki coupling reaction between aryl carboxylic acids and arylboronic acids to yield unsymmetrically substituted biaryl ketones. The effect of reaction conditions viz., solvent, base, temperature, catalyst loading were evaluated, and complex 4 was found to be an excellent catalyst with a maximum TOF of 19.8 min−1.
Cascade Nucleophilic Addition/cyclization/C−N Coupling of o‐Iodo‐phenyl Isothiocyanates with Propargylamines: Access to Benzimidazo[2,1‐b]thiazole Derivatives
Authors: Zhong Xianqiang , He Feng , Ran Qiuye , Li Wenjing , Xiong Huilan , Zhou Wei 
Published: September 2021

AbstractA highly efficient and mild sequential nucleophilic addition/ cyclization/copper catalyzed C−N coupling reaction of o‐iodophenyl isothiocyanates with propargylamines has been realized, which delivers a variety of benzimidazo[2,1‐b]thiazole derivatives in good yields. Moreover, this protocol could be performed at gram scale and applied to the concise synthesis of tilomisole.
Atomically Dispersed s‐Block Magnesium Sites for Electroreduction of CO2 to CO
Authors: Wang Qiyou , Liu Kang , Fu Junwei , Cai Chao , Li Huangjingwei , Long Yan , Chen Shanyong , Liu Bao , Li Hongmei , Li Wenzhang , Qiu Xiaoqing , Zhang Ning , Hu Junhua , Pan Hao , Liu Min 
Published: September 2021

AbstractAtomically dispersed transition metal sites have been extensively studied for CO2 electroreduction reaction (CO2RR) to CO due to their robust CO2 activation ability. However, the strong hybridization between directionally localized d orbits and CO vastly limits CO desorption and thus the activities of atomically dispersed transition metal sites. In contrast, s‐block metal sites possess nondirectionally delocalized 3s orbits and hence weak CO adsorption ability, providing a promising way to solve the suffered CO desorption issue. Herein, we constructed atomically dispersed magnesium atoms embedded in graphitic carbon nitride (Mg‐C3N4) through a facile heat treatment for CO2RR. Theoretical calculations show that the CO desorption on Mg sites is easier than that on Fe and Co sites. This theoretical prediction is demonstrated by experimental CO temperature program desorption and in situ attenuated total reflection infrared spectroscopy. As a result, Mg‐C3N4 exhibits a high turnover frequency of ≈18 000 per hour in H‐cell and a large current density of −300 mA cm−2 in flow cell, under a high CO Faradaic efficiency ≥90 % in KHCO3 electrolyte. This work sheds a new light on s‐block metal sites for efficient CO2RR to CO.
In‐Situ Templating Growth of Homeostatic GeP Nano‐Bar Corals with Fast Electron‐Ion Transportation Pathways for High Performance Li‐ion Batteries
Authors: Zeng Tianbiao , Liu Xingang , Kang Wenbin , He Hanna , Zhang Jihai , Li Xiaolong , Zhang Chuhong 
Published: September 2021

AbstractWe propose an in situ template method to directionally induce the construction of germanium phosphide nanobar (GeP‐nb) corals with an adjustable aspect ratio. The GeP nanobars grown onto conductive matrix with high aspect ratio expose more quickest electron‐ion transportation facets for fast reaction dynamics. The customized GeP‐nb electrode delivers a self‐healable homeostatic behavior by reversibly stabilizing GeP crystalline structure through multi‐phase reactions to maintain structural integrity and cycling stability (850 mAh g−1 at 1 A g−1 after 500 cycles). As a result, the GeP‐nb presents the highest Li+ diffusion coefficient (6.21×10−11 cm2 s−1) among all the Ge‐based anode materials studied so far, rendering an excellent rate performance (620 mAh g−1 at 5 A g−1) as a lithium‐ion battery (LIB) anode.
In Vivo Self‐Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization
Authors: Guo Ruo‐Chen , Zhang Xue‐Hao , Fan Peng‐Sheng , Song Ben‐Li , Li Zhi‐Xiang , Duan Zhong‐Yu , Qiao Zeng‐Ying , Wang Hao 
Published: September 2021

AbstractTherapeutic peptides have been widely concerned, but their efficacy is limited by the inability to penetrate cell membranes, which is a key bottleneck in peptide drugs delivery. Herein, an in vivo self‐assembly strategy is developed to induce phase separation of cell membrane that improves the peptide drugs internalization. A phosphopeptide KYp is synthesized, containing an anticancer peptide [KLAKLAK]2 (K) and a responsive moiety phosphorylated Y (Yp). After interacting with alkaline phosphatase (ALP), KYp can be dephosphorylated and self‐assembles in situ, which induces the aggregation of ALP and the protein‐lipid phase separation on cell membrane. Consequently, KYp internalization is 2‐fold enhanced compared to non‐responsive peptide, and IC50 value of KYp is approximately 5 times lower than that of free peptide. Therefore, the in vivo self‐assembly induced phase separation on cell membrane promises a new strategy to improve the drug delivery efficacy in cancer therapy.
Synthesis and application of amine‐sulfone‐rich mesoporous organic polymer for the ultrafast removal of both cationic and anionic organic pollutants from industrial wastewaters
Authors: Zargoosh Kiomars , Naghshineh Homeira , Soltani Roozbeh , Dinari Mohammad 
Published: September 2021

AbstractWater pollution is becoming an up‐rising threat to the environment and human being in recent years and turning to a major global challenge. The wastewaters released by the textile and dyestuff industries are one of the major sources of contamination. The aim of this work is preparation of stable, reusable, and fast adsorbent for complete removal of both cationic and anionic pollutants from industrial wastewaters. To obtain these goals, an amine‐sulfone‐rich mesoporous organic polymer (Daps‐POP) was synthesized, structurally characterized and applied for removing of methylene blue (MB) and direct blue 108 (DB‐108) as cationic and anionic model dye pollutants, respectively. The affecting variables on the adsorption process were optimized and the possible adsorbate‐adsorbent interactions were identified. The synthesized Daps‐POP was applied to industrial wastewaters and presents complete removal of model dye pollutants proving the idea of using POPs in industrial wastewater treatments. The equilibrium adsorption capacity (qe) found to be 48.1 mg.g−1 and 25.64 mg.g−1 for MB and DB‐108, respectively. The adsorption takes place in only 5 min for both dyes. Moreover, the reusability of the Daps‐POP was successful during three consecutive runs corroborating its promising application in industrial water treatment.
Ontogenetic variation in human nasal morphology
Authors: Butaric Lauren N. , Nicholas Christina L. , Kravchuk Katherine , Maddux Scott D. 
Published: September 2021

AbstractInternal nasal cavity morphology has long been thought to reflect respiratory pressures related to heating and humidifying inspired air. Yet, despite the widely recognized importance of ontogeny in understanding climatic and thermoregulatory adaptations, most research on nasal variation in modern and fossil humans focuses on static adult morphology. This study utilizes cross‐sectional CT data of three morphologically distinct samples (African, European, Arctic) spanning from infancy to adulthood (total n = 321). Eighteen landmarks capturing external and internal regions of the face and nose were subjected to generalized Procrustes and form‐space principal component analyses (separately conducted on global and individual samples) to ascertain when adult‐specific nasal morphology emerges during ontogeny. Across the global sample, PC1 (67.18% of the variation) tracks age‐related size changes regardless of ancestry, while PC2 (6.86%) differentiates between the ancestral groups irrespective of age. Growth curves tracking morphological changes by age‐in‐years indicate comparable growth trajectories across all three samples, with the majority of nasal size and shape established early in ontogeny (<5 years of age). Sex‐based trends are also evident, with females exhibiting a more truncated growth period than males, particularly for nasal height dimensions. Differences are also evident between the anterior and posterior nose, with the height and breadth dimensions of the anterior nasal aperture and nasal cavity showing differential ontogenetic patterns compared to the choanae. Cumulatively, these results suggest that multiple selective pressures influence human nasal morphology through ontogenetic processes, including metabolic demands for sufficient oxygen intake and climatic demands for adequate intranasal air conditioning.