bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-sectional study on skin prick test reactivity to common aeroallergens among allergic rhinitis patients in Southern India
Authors: Pratap Deepika , Parbat Abhishek Narayan , G. Ravikeerthi , K. G. Somashekara , Balakrishna Vibha , Suresh Shaalini 
Published: December 2024

Abstract
Background
Allergic rhinitis (AR) is the most common cause of rhinitis impairing quality of life. The prevalence of allergic rhinitis varies considerably across countries and regions. Our cross-sectional study aims to identify the common aero-allergens in a tertiary care hospital in Southern India.

Methods
A cross-sectional study of 50 patients with allergic rhinitis was done over a period of 6 months in a tertiary care center in Southern India. Skin prick test was performed on the eligible candidates and correlated with their symptoms.

Results
The most common presentation was sneezing (96%). The majority were found to be sensitized to more than one set of allergens. The most common allergen was found to be house dust mite (D. Farinae 58%, D. pteronyssinus 54%, Blomia 48%), followed by Parthenium (38%) and Cockroach (32%).

Conclusion
Our results explore the clinical profile of allergic rhinitis patients and its correlation with skin prick tests. The most common aero-allergen found was house dust mite.
Surgical explantation of an infected Lotus Edge valve: a case report
Authors: Yanagino Yusuke , Kainuma Satoshi , Kawamoto Naonori , Tadokoro Naoki , Kakuta Takashi , Ikuta Ayumi , Tonai Kohei , Fujita Tomoyuki , Fukushima Satsuki 
Published: December 2024

Abstract
Background
With the rapid expansion of transcatheter aortic valve replacement (TAVR), TAVR valve explantation is also increasing. Nevertheless, previous reports on Lotus Edge valve explantation are limited to only two reports, none of which include intraoperative videos. Therefore, we report the case of an older adult who underwent a 2-year-old Lotus Edge valve explantation, after developing prosthetic valve endocarditis (PVE) and aortic annular abscess, with a strong indication for a TAVR explantation and surgical aortic valve replacement (AVR).

Case presentation
An 85-year-old male patient, who underwent TAVR with a 25-mm Lotus Edge valve for severe aortic stenosis 2 years ago, was referred to our hospital. He presented with a 1-month history of high-grade fever, refractory to oral antimicrobials and trifascicular heart block. Two sets of blood cultures were positive for Streptococcus dysgalactiae subspecies equisimilis, and transesophageal echocardiography revealed vegetation on the valve leaflets. Enhanced computed tomography scan showed thickening and enhancement of the aortic root and aorto-mitral continuity, with a small low-density area. Therefore, we diagnosed PVE. Subsequently, we planned AVR re-intervention and pacemaker implantation. The vegetation mass was attached to the aortic valve leaflet. We attempted to explant the valve while deforming it using forceps. The areas with abscess formation were easily dissected; however, the other areas were difficult to separate. Cold-saline irrigation softened the nitinol stent and enabled to dissect the prosthetic valve from the aortic wall. The infected aortic annulus was irrigated and then repaired. AVR using a 21-mm Avalus bioprosthetic valve and epicardial pacemaker lead implantation were simultaneously performed. Postoperative echocardiography confirmed that the prosthetic valve function was favorable, and the patient was transferred to a rehabilitation hospital after 6 weeks of intravenous antimicrobial therapy.

Conclusion
The Lotus Edge valve is difficult to remove due to its fixation after deployment and strong adhesion, but the use of cold water may be effective in facilitating its removal.
Valve-sparing procedure for acute aortic regurgitation due to intimal intussusception in a minimally localized aortic root dissection
Authors: Matsushiro Takuya , Tamura Tomoki , Ishiwaki Daiki , Umibe Takumi , Inoue Nobuyuki 
Published: December 2024

Abstract
Background
Acute heart failure due to aortic regurgitation (AR) is a severe comorbidity of type A acute aortic dissection (AAD). Valve-sparing aortic root replacement is typically performed when the aortic valve remains intact.

Case presentation
A 33-year-old male presented to our hospital with chest pain. Initial computed tomography (CT) scans did not clearly identify an aortic dissection. However, subsequent evaluations suggested acute coronary syndrome. Catheter angiography revealed difficulties in catheterizing the coronary arteries, and echocardiography detected aortic insufficiency. Electrocardiogram-gated CT angiography ultimately confirmed a localized aortic root dissection, necessitating urgent surgical intervention. The patient underwent valve reimplantation to preserve the aortic valve. The postoperative course was uneventful, with follow-up echocardiography and CT showing no residual dissection or regurgitation.

Conclusion
This report highlights a case of acute aortic root dissection resulting in acute AR. The primary cause of AR in this case was the intussusception of the disrupted aortic intima. The dissection was confined solely to the aortic root. The patient underwent successful valve reimplantation, with no postoperative complications. Electrocardiogram-gated CT angiography and transesophageal echocardiography proved valuable in identifying localized aortic abnormalities with precision.
Surgical management of a huge mediastinal mature teratoma in a 2-year-old girl: a case report
Authors: Matsui Yusuke , Shiono Satoshi , Mizumoto Masahiro , Nakamura Megumi , Suzuki Jun , Watanabe Hikaru , Uchida Tetsuro 
Published: December 2024

Abstract
Background
Mature teratomas are benign cystic tumors that are most commonly asymptomatic. However, in some cases, mediastinal teratomas rupture the lungs and mediastinum with potentially fatal outcomes. Herein, we report a case of a large mediastinal mature teratoma that expanded to the entire left hemithorax in a child with common cold-like symptoms.
Case presentation.
A 2-year-7-month old girl visited a family doctor because of cough and rhinorrhea. Chest radiography revealed a large tumor occupying the left hemithorax, necessitating transfer to our institution. Chest computed tomography (CT) revealed a large tumor with calcifications and an encapsulated surface. The lesion was 10.5 cm in size and covered the entire left hemithorax, deviating significantly from the heart. CT suggested a mature mediastinal teratoma. Considering the risk of tumor dissemination, we did not perform a diagnostic biopsy; however, surgery was performed as an oncological emergency. As ventilation and circulation were difficult to maintain during the surgery, extracorporeal membrane oxygenation was performed. During surgery, although the large tumor tightly adhered to the sternum and innominate vein, it could be safely removed from these structures, and the tumor was completely removed through median sternotomy. The pathological diagnosis revealed a benign mature mediastinal teratoma. The patient’s postoperative course was uneventful.

Conclusion
As the clinical course of child-specific problems in mature teratomas tends to be severe, a surgical strategy should be meticulously planned to ensure safety.
Alone and Together: Exploring the Relationship Between Individual and Social Metacognition in College Biology Students During Problem Solving
Authors: Bremers Emily K. , McKay Olive K. , Stanton Julie Dangremond 
Published: December 2024

This qualitative study of metacognition in upper-level biology undergraduates used in-the-moment data to reveal complexity in the relationship between students's individual and social metacognition while problem solving. Interestingly, students more readily corrected and evaluated their group members' ideas compared to their own ideas.
Implementation Strategy for Artificial Intelligence in Radiotherapy: Can Implementation Science Help?
Authors: Swart Rachelle , Boersma Liesbeth , Fijten Rianne , van Elmpt Wouter , Cremers Paul , Jacobs Maria J.G. 
Published: December 2024

PURPOSE
Artificial intelligence (AI) applications in radiotherapy (RT) are expected to save time and improve quality, but implementation remains limited. Therefore, we used implementation science to develop a format for designing an implementation strategy for AI. This study aimed to (1) apply this format to develop an AI implementation strategy for our center; (2) identify insights gained to enhance AI implementation using this format; and (3) assess the feasibility and acceptability of this format to design a center-specific implementation strategy for departments aiming to implement AI.

METHODS
We created an AI-implementation strategy for our own center using implementation science methods. This included a stakeholder analysis, literature review, and interviews to identify facilitators and barriers, and designed strategies to overcome the barriers. These methods were subsequently used in a workshop with teams from seven Dutch RT centers to develop their own AI-implementation plans. The applicability, appropriateness, and feasibility were evaluated by the workshop participants, and relevant insights for AI implementation were summarized.

RESULTS
The stakeholder analysis identified internal (physicians, physicists, RT technicians, information technology, and education) and external (patients and representatives) stakeholders. Barriers and facilitators included concerns about opacity, privacy, data quality, legal aspects, knowledge, trust, stakeholder involvement, ethics, and multidisciplinary collaboration, all integrated into our implementation strategy. The workshop evaluation showed high acceptability (18 participants [90%]), appropriateness (17 participants [85%]), and feasibility (15 participants [75%]) of the implementation strategy. Sixteen participants fully agreed with the format.

CONCLUSION
Our study highlights the need for a collaborative approach to implement AI in RT. We designed a strategy to overcome organizational challenges, improve AI integration, and enhance patient care. Workshop feedback indicates the proposed methods are useful for multiple RT centers. Insights gained by applying the methods highlight the importance of multidisciplinary collaboration in the development and implementation of AI.
Prospective Observational Study on Moderate Hypofractionated Radiotherapy for Localized Prostate Cancer in Rwanda: Acute Toxicity in Patients
Authors: Sinzabakira Felix , Heemsbergen W.D. , Mugenzi Pacifique , Ndoli A. Diane , Maniragaba Theoneste , Umubyeyi Claire , Rubagumya Fidel , Mutabazi Emmanuel , Incrocci Luca 
Published: December 2024

PURPOSE
Moderate hypofractionation (MHF) offers logistical and financial advantages, and has become standard in Western countries but not yet in Africa. This study assessed GI and genitourinary (GU) acute toxicity in Rwandan men undergoing MHF (20 × 3 Gy) treatment.

MATERIALS AND METHODS
Since 2021, patients with prostate cancer at the Rwanda Cancer Centre have been informed about the study on MHF treatment and could participate by signing an informed consent. The study included patients with confirmed prostate adenocarcinoma (any T, any prostate-specific antigen any Gleason score, N0M0), excluding those with inflammatory bowel disease, previous pelvic irradiation, or previous prostatectomy. Participants received 20 fractions of 3 Gy over 4 weeks using the volumetric modulated arc radiotherapy (RT) technique with a 6 megavoltage linear accelerator. GI and GU acute toxicity was evaluated at week 2, at the end of RT, and 3 months after treatment using the Radiation Therapy Oncology Group (RTOG) acute toxicity grading system.

RESULTS
Fifty consecutive patients with localized prostate cancer were included. The median patient age was 70 years. Most patients (86%) had high-risk disease and 94% received androgen-deprivation therapy. The cost and treatment time were reduced by 50%. The distribution of maximum acute RTOG toxicity scores were for GI 10% grade 0, 70% grade 1, 20% grade 2, 0% grade 3, and for GU scores were 0%, 40%, 54%, and 6%, respectively. By 3 months, RT symptoms had returned to baseline levels for most patients.

CONCLUSION
MHF (20 × 3 Gy) was well tolerated in men treated for prostate cancer in Rwanda, showing that MHF is feasible in an African setting. However, further research on acute and late toxicity for more patients is warranted.
Cell-Based Assays to Detect Innate Immune Response Modulating Impurities: Application to Biosimilar Insulin
Authors: Her Cheng , Thacker Seth , Balsamo Joseph , Kelley Baker Logan , Ireland Derek DC , Pang Eric , Verthelyi Daniela 
Published: December 2024

Abstract
Characterizing and mitigating factors that impact product immunogenicity can aid in risk assessment and/or managing risk following manufacturing changes. For follow-on products that have the same indication, patient population, and active product ingredient, the residual immunogenicity risk resides predominantly on differences in product and process related impurities. Characterizing differences in innate immune modulating impurities (IIRMI), which could act as adjuvants by activating local antigen presenting cells (APCs), can inform the immunogenicity risk assessment potentially reducing the need for clinical trials. To date, assays to detect trace levels of IIRMI are being used to support regulatory decisions by FDA for selected synthetic peptide drug products that refer to reference listed drugs of rDNA origin but not recombinant protein or peptide products where more complex mixtures of trace impurities including host cell proteins are expected. Here we describe an exercise to explore whether or not there are differences in the innate immune response elicited by an insulin glargine (produced in E. coli) and its interchangeable biosimilar insulin (produced in P. pastoris) that could indicate differences in IIRMI. Our results suggest the two products elicit comparable innate immune responses as determined by the expression of 90 immune-related genes, including IL-1α, IL-1β, IL-6, CCL3, CCL2, and CXCL8. The data suggest that these assays can provide useful information when assessing recombinant proteins for the presence of IIRMI.

Graphical Abstract
Introduction
Authors: Celermajer Danielle , Otjen Nathaniel 
Published: December 2024

Abstract
Narratives form one dimension of the institutional ecology that shapes what can happen for different types of beings, the modes of relationships available to them, and the possibilities of their lives. This introduction considers the limitations and possibilities that narrative poses for multispecies justice. It sets out four ways in which narrative strategies impede multispecies justice, by (1) presenting (certain) humans as the sole subjects of justice; (2) naturalizing the association between putatively exclusive human capacities and being a subject of justice; (3) normalizing the background conditions that produce humans as the privileged subjects of justice; and (4) positioning humans as the sole agents capable of producing story. It then considers three ways that narrative might help theorize and develop multispecies justice, by (1) imagining, depicting, and evoking the lives of more-than-human others; (2) recognizing storytelling itself as a more-than-human practice; and (3) elaborating the narrative form as a multispecies practice unfolding through more-than-human relationships.
“By Eel's Verve”
Authors: Dunn Kirsty 
Published: December 2024

Abstract
This essay elucidates how the experiences of the tuna (eels) endemic to Aotearoa, New Zealand, and the many ways they have been represented in narrative form exemplify the dynamism of whakapapa (origins, relationships, genealogical knowledge, and layer-making) in Te Ao Māori (the Māori world). Tuna are at once treasured whanaunga (relations), valued sources of sustenance, indicators of the health of the country's waterways, mysterious boundary-breakers, and slippery subjects who often feature in Māori art and literature. Considering tuna and their lifeways can provide multiple ara (passageways or routes) for critically reflecting on their multispecies relations and on how those relations may be made more just. Through the discussion of ancestral narrative, as well as poetry, prose, and visual artworks that center the perspectives and characteristics of tuna, the essay explores the ways Māori worldviews, knowledges, and te reo Māori (the Māori language) draw to, from, and with tuna and help us as Māori understand and maintain our relationships with, and obligations to all our other-thanhuman relations. In doing so, the essay gestures to the ways in which wider multispecies justice initiatives might find alignments within these representations and relationships too
Night Songs
Authors: Taylor Hollis , Rose Jon 
Published: December 2024

Abstract
This article's authors record, transcribe, and analyze Australian pied butcherbird songs much as a musicologist might study any human music. They also arrange some of these vocalizations for human musicians. Here, the authors detail a recent interspecies engagement entitled Night Songs. This multimedia concert cultivates audience engagement by striving to create as deep a listening experience as the authors' was in the field. The music partner for the authors' (re)compositions is a field recording, typically of the avian composer in question; this allows musicians to perform across a perceived divide and audiences to make direct comparisons of avian and human musicians. As songbird aesthetics emerge in the concert hall, they challenge hierarchies of creative power. Night Songs folds concepts of multispecies justice into storytelling. This rich, varied, and often familiar-sounding avian vocal culture prompts a rethink of species boundaries, prompting narratives of enchantment and connection to replace those of exceptionalism
Attuning to the Pluriverse
Authors: Carbonell Isabelle 
Published: December 2024

Abstract
Environmental issues in mainstream documentary film have been aestheticized and personified through specific filmmaking methods such as talking-head interviews, single-character narrative arcs, and three-part dramatic structures. These anthropocentric approaches can make it difficult to pay attention to slower temporalities and more-than-human lifeworlds that are at the crux of understanding slower-moving environmental disasters. The groundwork for the ecological collapse of an ecosystem is often only partially discernible within a human time frame, encompassing connections across species, seasons, elements, genres, and time and space too temporally and spatially vast, too micro- or macroscopic to be captured as visible evidence, and therefore more experimental film practices are needed to register these scalar frequencies. Multispecies cinema is a new mode of filmmaking that centers the more-than-human through several experimental methodological expansions, with the goal of decentering the human while narrativizing ecosystems in trouble.
Steps toward Kinship
Authors: Ybarra Priscilla Solis 
Published: December 2024

Abstract
In this essay, Ybarra shares her experience of the Nibi Walk as one way to conceptualize practices of accountability and critical solidarity across cultures and modes of being, including the way the Nibi Walk's structure fundamentally disrupts concepts of linearity. Although Ybarra continues to ask some of the same questions she had when she first entered into the water walking ceremony, she gathers a bit more experience and knowledge every time she returns to the circle, every time she finds a different path into the inquiry. What she first learned growing up surrounded by Mexican American storytellers becomes confirmed without a doubt—that questions are more about the asking and the process of listening than they are about any particular answer. Reaching for justice and taking steps toward kinship takes humility before an ever-spiraling cyclical process.
«THE EMPLOYEE WELL-BEING WHEEL»: RESULTS OF THE CONCEPTUAL MODEL TESTING
Authors: Elaneva D. , Fedorova A. 
Published: December 2024

In the context of contemporary challenges for Russian business, human resource management strategies of enterprises are becoming increasingly humancentred, programs for supporting employee well-being are being actively implemented, and new ways of managing engagement, loyalty, and job satisfaction are being sought, which are integral components of well-being at work. The purpose of the pilot study is to develop and test a methodological approach to monitoring the level of employee well-being, which includes the conceptual model “Employee Well-being Wheel” and a subjective assessment tool for indicators of engagement, loyalty, and job satisfaction in the form of a questionnaire. Empirical data collection was carried out at a meat and dairy enterprise in 2023–2024 with the involvement of 10 employees from the Human Resources Department. Processing and analysing the data obtained was carried out in the logic of the conceptual model, within which employee well-being is considered as a holistic phenomenon consisting of its elements: physical and mental health, personal and professional development, social relationships and ties, opportunities for rest, financial stability. An important part of the author’s methodology is the visualization of the analysis results, which contributes to the improvement of the interpretation processes of cause-and-effect relationships, the identification of hidden trends, and the making of management decisions aimed at maintaining the well-being of the enterprise’s employees. As a result of the pilot study, the expediency of applying the author’s methodology at the enterprise was confirmed, as well as the need for the next stage with an increase in the number of employees involved in the study.
The Impact of the Ketogenic Diet on the Metabolic Profile, Hormonal Balance and Fertility in Women with PCOS
Authors: Turemka Mariola , Mandziuk Aneta , Cygnarowicz Aleksandra , Wojtas Aneta Klaudia , Zabojska Krystyna , Korotko Urszula , Witowska Kinga , Biskupski Mikołaj , Hosseinnejad Negar , Sacher Karolina 
Published: December 2024

Introduction: Polycystic ovary syndrome(PCOS) is the most common endocrine disorder among women of reproductive age. It is characterized by clinical symptom caused by high androgen level such as acne, hirsutism and irregular menstrual cycles. The cause of PCOS is unknown but both genetic and environmental factors are believed to play a role. The key elements in the patogenesis of this syndrome are insulin resistance, hyperinsulinemia and hyperandrogenism. PCOS increases the risk of metabolic and cardiovascular diseases. The aim of this review is to describe the efficiency, safety and potential benefits of the ketogenic diet on the metabolic profile, hormonal balance and fertility in women with PCOS.
Materials and methods: A literature review was conducted using the databases such as Pubmed and Google Scholar.
Results: The ketogenic diet focuses on reducing carbohydrate intake while proportionally increasing fat and protein consumption. This diet reduces insulin resistance and positively impacts Patients’ metabolic profile and hormonal balance. This contributes to improve fertility in women, who often experience difficulty conceiving.
Conclusion: The results of the studies show that the ketogenic diet has a positive effect on metabolic profile and hormonal balance in Patients with PCOS. However, further research is needed in larger groups of Patients and over longer periods of time to evaluate whether it can become an effective form of therapy for PCOS Patients.