bluuebunny/crossref_metadata_2025_split huggingface dataset:
Religious Challenges to Anti-Discrimination Law: The Mobilization of the “Minority Label”
Authors: Brière-Godbout Léa , Plante Marie-Andrée 
Published: December 2021

In 2018, the American and Canadian supreme courts released two high-profile decisions: the case of a Christian baker from Colorado who refused to create a cake for the celebration of a same-sex couple’s union, and the case of an evangelical Christian law school in British Columbia whose code of conduct prohibiting same-sex intimacy led to accreditation refusals by three provincial law societies. In both cases, religious believers argued that modern LGBTQ2+ anti-discrimination protections required them to act in ways that proved incompatible with their religious beliefs. While such “conflict of rights” are familiar to liberal democracies, this article demonstrates how these cases operate within a new paradigm in which religious actors, seeking exemptions from legal protections accorded to a vulnerable minority, claim minority status for themselves. Hoping to have their policy agenda seen in a new light, such opponents of LGBTQ2+ rights have replaced their discourse defending traditional mores with one arguing that the broadly cherished value of pluralism guarantees them a religious right to “dissent” from anti-discrimination protections. We dub this discursive process the mobilization of the “minority label.”
In this article, we retrace the emergence of this new discourse by turning to the narratives crafted by parties, courts, and media in the two cases. We discuss the three main argumentative strategies through which the minority label manifests in discourses: language framing, moral symmetry arguments, and respectability claims.
We then offer a comparative analysis which explores the different ways both courts reacted to this discourse. We conclude with a brief discussion of some of the long-term risks that the rise of such a discourse implies for LGBTQ2+ rights.
A Study on Adoption of Indigenous Technical Knowledge Practices among Tribal Farmers in Kolli Hills
Authors: Keerthana V. , Divakaran A. 
Published: December 2021

Objectives: To make a quantitative study of Indigenous Technical Knowledge (ITK) practices pertinent to crops grown in Kolli hills tribes in the Namakkal district of Tamil Nadu, India.
Methods: The attempt was made to study the adoption level of the interpreted ITKs among Kolli hills tribes. The Kolli hill was picked purposively for its uniqueness in continuing their traditions age old practices in farming practices by the tribes. The present study has been carried out in the Namakkal district of Tamil Nadu state. The Namakkal district was administratively divided into seven taluks and fifteen blocks. Among these seven taluks and fifteen blocks, higher populations of tribes were seen at Kolli hills. For the selection of the respondents based on the proportionate random sampling technique and the data were collected from each respondent through personal interview method. The study was carried during 2019 with 150 respondents in highly populated villages of Kolli hills. The Adoption index was used to analyse the adoption level of the ITK’s by the tribes.
Findings: More than half of the respondents (55.56 per cent) had a medium level of knowledge followed by high (25.10 per cent) and low (19.34 per cent) levels of knowledge on indigenous cultivation practices.
Conclusion: Indigenous technical knowledge has a substantial heritage in agrarian civilization. The findings highlight the effectiveness of indigenous technical knowledge above its modern equivalent. Thus, extension workers should identify and incorporate them in the technology transfer action in order to ensure long-term or sustainable agricultural development.
Study of Antioxidants Vitamin E and Ascorbic Acid level in Pre-eclampsia and Normotensive Pregnant Women Attending the Antenatal Department of a Rural Hospital in Imo State South East Nigeria
Authors: Nnamdi C. J. J. , Izuchukwu E. C. O. , Nwaisaac I. S. , Okeke S. C. , Ukodei F. U. , Ahams E. C. , Uzoma R. I. , Iwuagwu O. G , Ezinwa A. A. 
Published: December 2021

Background: Deficiencies of nutrition are common during pregnancy especially in developing countries. Pregnant women in developing countries have been reported to consume diets that are low in minerals and vitamins. Inadequate dietary intake during pregnancy might be a high risk not only for the mother but also for the fetus. Deficiencies of antioxidant vitamins have been implicated in various reproductive disorders like infertility, congenital anomalies, pre-eclampsia, placental abruption, premature rupture of membranes, still births and low birth weight.
Objective/Aim: This investigation was performed to compare the level of serum antioxidant vitamin E and Ascorbic Acid status in women with preeclampsia and normal pregnancy in Imo State. It was a randomized cross sectional study of 50 preeclampsia and 50 normotensive pregnant women attending the Dept. of Medicine and Antenatal clinic of specialist Hospital Umuguma, Owerri Imo State Nigeria. The study protocol was reviewed and the ethical committee and participants gave their consent. Data analysis was done using the statistical package for social sciences (SPSS) version 20.0. P-value of < 0.05 was considered to be statistically significant.
Results: The mean antioxidant vitamins E and C were significantly lower in the preeclampsia group (0.29±0.07 and 0.31±0.20mg/dl) against the control (0.64±0.16 and 0.89±0.27mg/dl) P<0.05 respectively.
Conclusion: The study showed significant decrease in the level of vitamin E and Ascorbic Acid suggesting the failure of compensatory antioxidant functions in preeclampsia women.
Therapeutics Effects and Health Benefits of the Caucasus Koumiss: A Review
Authors: Kirdar S. S. 
Published: December 2021

Koumiss (koumyss, kumiss, kumys, kumyz, kimiz or coomy) has been popular in Kyrgyzstan, Kazakhstan, Mongolia, and the Turkic, Mongolian, and Caucasian peoples of Russia: Altay, Bashkortostan, Buryatia, Dagestan, Kabardino-Balkaria, Kalmykia, Karachaevo-Cherkessia, Tatarstan, Tyva, Chuvashia, and Saha (Yakutia). Many countries in numerous Central Asian countries provide Koumiss therapeutic services, which are primarily provided by small and medium-sized accommodation firms that are particularly active in rural areas of those countries.
Koumiss is classified as a functional food due to its nutritional and medicinal properties. Many health benefits of koumiss include high probiotic content; antibacterial and antifungal characteristics; regulation of immunity; maintenance of a healthy gastric-intestinal system; regulation of cholesterol and sugar levels; regulation of blood pressure; and induction of some important vitamins. The objective of this review is to provide a comprehensive summary of the health benefits of koumiss.
Soil Suitability for Growing Horticultural Crops in Kanamadi South Sub-Watershed of Karnataka
Authors: D. Souza Ashay , Patil P. L. 
Published: December 2021

The suitability of the land resources in the watershed for various crops is necessary to choose the right crop and variety suitable for the area. In carrying out this assessment, the specific land requirements of a crop are compared with the characteristics of land resource mapped in the sub- watershed with this objective investigation was carried to assess land suitability for growing horticultural crops in Kanamadi South sub-watershed of Vijayapura district of Karnataka. The soil survey was conducted using 1:7920 scale, LISS IV satellite imagery. The soils were shallow to deep with clay loam to clay in texture. The soils were low in nitrogen and organic carbon, low to medium in phosphorus and sulphur, medium to high in potassium. Iron, copper, zinc and manganese were sufficient. Land suitability evaluation revealed that soils were moderately suitable for growing fruits such as guava (73.75% TGA), pomegranate (70.73% TGA), sapota (85.65% TGA). In case of flowers, major part of the study area was marginally suitable for crops such asrose (65.26% TGA) and jasmine (91.72% TGA). Around 11.55 per cent of the area was evaluated as unsuitable for growing fruit crops. The consideration of depth and nutrient status of soil in sub-watershed area is ideal to grow the horticultural crops like fruit crops with soil conservation measures to obtain food sustainability and nutrition level of people living the study area.
Physiotherapy Rehabilitation in Subject with Scapular Osteochondroma: A Case Report
Authors: Thakare Vaishnavi , Phansopkar Pratik , Chitale Neha 
Published: December 2021

Introduction: The most prevalent benign tumour affecting the metaphysis of long bone is osteochondroma, a form of cartilaginous tumour. Solitary or multiple osteochondromas can prevail.Hereditary multiple exostosis (HME) or familial osteochondromatosis is the multiple variant, which is an autosomal dominant syndrome.
Case Presentation: A 35-year old female with right-hand dominance was referred todepartment of physiotherapy. On palpation small nodular swelling of marble size was present in left axilla. X-rays findings showed increased scapular mass and ribs were compressed laterally.
Discussion: The most widespread benign tumour is osteochondroma. In 3.0-6.4 percent of all instances, the scapula is implicated. The osteochondroma normally develops on the scapula's anterior aspect. The scapula osteochondroma induces pain and a grating sound when the scapula is moved. Mechanic irritation of muscle, tendon, or soft tissue, emergence of a pseudoaneurysm or bursa, fracture, or malignant transformation are all causes of symptoms.
Conclusion: Osteochondroma is a common benign tumor. Management of osteochondroma is important to improve the quality of life. Physiotherapy plays an important role in managing Scapular osteochondroma.
Predictive Risk Factors for Mild and Severe Germinal Matrix Hemorrhage and Associated Neurodevelopmental Prognosis: A Retrospective Study
Authors: Alhakeem Wejdan , Almuhana Afnan , Alshahrani Haya , Alkhateeb Moneerah , Alsaihati Zahra 
Published: December 2021

Aims: To compare commonly mentioned risk factors between mild germinal matrix hemorrhage-Intraventricular hemorrhage (GMH-IVH) (grade I & II) and severe GMH-IVH (grade III & IV) and to study the long-term neurodevelopmental outcomes in relation to severe GMH-IVH.
Study Design: Retrospective cohort study.
Place and Duration of Study: Neonatal intensive care unit, King Fahad University Hospital, between 2000 and 2020.
Methodology: We included 54 premature infants at ≤36 weeks of gestation and with birth weight <2500g admitted to our neonatal intensive care unit. Premature neonates were divided into two subgroups: mild GMH-IVH (grade I and II) and severe (grade III and IV). We investigated the risk factors and neurodevelopmental outcomes in association with GMH-IVH.
Results: Amnionitis (OR: 1.190, 95% CI 0.515-2.749), lower genital tract infection (OR: 1.190, 95% CI 0.515-2.749), antenatal infection (OR: 1.406, 95% CI 0.866-2.283), gestational diabetes mellitus (OR: 1.815, 95% CI 1.410-2.337), usage of inotropes (OR: 1.731, 95% CI 1.348-2.222), APGAR score <7 (OR: 0.806, 95% CI 0.493-1.316), birth trauma (OR: 1.767, 95% CI 1.396-2.236), catecholamines (OR: 1.470, 95% CI 0.903-2.393), intubation (OR: 1.300, 95% CI 0.686-2.464), asphyxia (OR: 1.135, 95% CI 0.718-1.794), Abnormal coagulation (OR: 1.197, 95% CI 0.756-1.896), congenital heart disease (OR: 1.727, 95% CI 1.124-2.653), low hematocrit (OR: 1.140, 95% CI 0.688-1.889), resuscitation (OR: 1,193, 95% CI 0.748- 1.904) and ventriculoperitoneal (VP) shunt as a prognosis of hydrocephalus (P-value: 0.005) all showed a higher incidence with severe GMH-IVH
Conclusion: Amnionitis, lower genital tract infection, antenatal infections, GDM, usage of inotropes, APGAR score <7, birth trauma, catecholamines, intubation, asphyxia, resuscitation, abnormal coagulation parameters, congenital heart disease, low hematocrit and hydrocephalus with VP shunt were higher in severe GMH-IVH.
A Rare Case of Renal Squamous Cell Carcinoma with Underlying Staghorn Calculus as Confounding Factor
Authors: Durge Shubham Pratap , Bhattacharjee Anurag Anupkumar , Ramteke Harshal , Gupta Abhishek , Kulkarni Varun , Shaha Shyamal , Mannek Roshani 
Published: December 2021

Renal cell carcinoma is one of the most common kidney pathologies in adults, responsible for approximately 90-95% of cases. The most common variant is clear cell accounting for 60-70% of cases, while papillary accounts for 10-15% of the cases.
Diagnosis of carcinoma in the presence of staghorn calculus is seen in less than 1% of patients in recorded data. However, squamous cell carcinoma of the kidney is a rare condition usually associated with chronic irritation by a foreign body, most likely due to staghorn calculus. Here we present a case report of a 65 year old male who came with complaint of pain in the abdomen since two months associated with malaise, weight loss and fever.
CT KUB was suggestive of a non-excreting enlarged left kidney with multiple calculi with abnormal cortical and periureteric lesions with encasement of adjacent vessels. Histopathological report revealed a rare case of primary squamous cell carcinoma, most probably originating from the pelvis and secondarily infiltrating the renal parenchyma and associated with nephrolithiasis and hydronephrosis. Initially the patient was managed conservatively. Later the patient underwent nephrectomy.
Evaluation of Hypolipidemic and Hepatoprotective Effects of Linum usitatissimum L. Seeds on Hypercholesterolemic Rats
Authors: Pattanayak Chaitali , Bahinipati Jyotirmayee , Srivastava Vartika , Sarkar Sougata 
Published: December 2021

Background: Hyperlipidaemia is a chronic progressive disease, which encompasses various genetic and acquired conditions resulting in inappropriately elevated lipid levels in humans. Several preclinical and clinical studies have demonstrated that dietary supplementation with Linum Usitatissimum have beneficial cardiovascular effects like antihypertensive action, antiatherogenic effects, lowering of cholesterol, anti-inflammatory action and inhibition of arrhythmia. There are few studies on hepatoprotective effects of flax seeds in hyperlipidemic animal models. Aim and objectives: Hence, this study was undertaken to evaluate the hypolipidemic and hepatoprotective effect of Linum seeds.
Methods: The study was conducted for the period of two months in Department of Pharmacology KIMS, Bhubaneswar. Total 36 Albino wistar rats were taken and divided into 6 groups containing 6 rats each. Group II was hypercholesterolemic (HC) control, Group III was treatment control and Group IV to VI rats were given different doses of extract. Blood samples were taken at the end of two months.
Results: All the values are expressed as Mean±SD (standard deviation). Significant decrease in lipid parameters and liver enzymes is seen at the end of two months in all 3 groups receiving the extract, where the highest dose of extract used, is near to the standard drug.
Conclusion: From this study, it can be concluded that the addition of the flaxseeds to the diet may alleviate the rise in circulating cholesterol levels induced by the high cholesterol diet through its content of alfa-linolenic acid (ALA) and lignins. The hepatoprotective role of flaxseed in hypercholesterolaemia has also been demonstrated in this this study.
Glibenclamide-Loaded Polyvinylpyrrolidone (PVP) Nanoparticles and Glibenclamide-Loaded Soluplus® Nanomicelles Intended for Parenteral Administration: Effect of Solvents Mixtures on the Electrosprayed Nanoparticles and In vitro Characterization
Authors: Al-Ghezi Maryam , Almilly Raghad F. , Ali Wedad K. 
Published: December 2021

Background and Objective: Glibenclamide (GB) is showing promising results in central nervous system (CNS) injuries treatment where intravenous administration of GB could overcome the oral limitations and assure maximum bioavailability. Dry powder of GB nanoparticles reconstituted for parenteral administration was prepared through electrospraying.
Methods: The drug was incorporated with two polymers, polyvinylpyrrolidone (PVP) and Soluplus® (SP), at ratios 1:4 and 1:2 (GB/polymer). Different solvent mixtures were used to formulate the particles. Physicochemical characteristics were investigated.
Results: The size of the GB-PVP nanoparticle ranged between (409-775) nm with a spherical, disk, fractured and, agglomerated morphology, while those of the GB-SP nanomicelles were of (447-785) nm with mostly irregular morphology, in consequence to the used solvents mixtures. The high encapsulation efficiency ≥ 98% reflects the well dispersed drug molecules within the polymer matrix, further confirmed by X-ray diffraction and infrared spectroscopy. GB-SP colloidal dispersions showed neutral zeta potentials with a cloud point of 36 ˚C, indicating prolonged circulation time and stability after parenteral administration. GB/SP nanomicelles at ratio 1:4 showed a sustained drug release reaching ≥ 94% in 36 hours.
Conclusion: The GB-SP nanomicelles with extended drug release and regarding physicochemical properties represent a remarkable drug delivery system for parenteral administration.
Clinical Presentation of the Epileptic Patients at People Medical College Hospital, Nawabshah, Pakistan
Authors: Daidano Jeando Khan , Makheja Haresh Kumar , Bhatia Moti Ram , Memon Waseem Raja , Jamali Anwar Ali , Tunio Safdar Ali Pervez , Ahmer Arslan 
Published: December 2021

Objective: study will determine clinical presentation, risk, and type of seizures in epileptic patients. Methodology: This observational study was conducted in Medicine department People Medical College Hospital (PMCH) Nawabshah from January 2020 to December 2020. 110 patients were included for study after informed permission of the patient or their relative. Male and female were selected. Known epileptic patients were included in the study, patients with false seizures were excluded from the study. Statically analysis was done by software SSPS 22 version.
Results: Age ranged 18 to 60 years. All the patients included in the study epilepsy was noted. The mean age of patients was 37.40 SD 8.71 years. The minimum age was 28 years while maximum 60 years. Pearson Chi-Square Value 105.000a Asymp. Sig. (2-sided) .000, Likelihood Ratio Value 135.012 Asymp. Sig. (2-sided) .000, Linear-by-Linear Association Value 16.297 Asymp. Sig. (2-sided) .000 which were statistically significant.
Conclusion: Epilepsy is treatable common neurological disease in Pakistan. quality of life can be improved by Education of the patients and their relatives, without socioeconomically burden.
A cross-sectional study on perceived workplace health support and health-related quality of life
Authors:   CORoNaWork Project, Kurogi Kazushirou , Ikegami Kazunori , Eguchi Hisashi , Tsuji Mayumi , Tateishi Seiichiro , Nagata Tomohisa , Matsuda Shinya , Fujino Yoshihisa , Ogami Akira 
Published: December 2021

Abstract

Objective
Many companies in Japan have been increasingly interested in “health and productivity management (H&PM).” In terms of H&PM, we hypothesized that companies can enhance their employees’ perceived workplace health support (PWHS) by supporting workers’ lively working and healthy living. This could then improve their health-related quality of life (HRQOL) by increasing PWHS. Consequently, this study explored the relationship between PWHS and HRQOL.

Methods
In December 2020, during the COVID-19 pandemic, we conducted an Internet-based nationwide health survey of Japanese workers (CORoNaWork study). A database of 27 036 participants was created. The intensity of PWHS was measured using a four-point Likert scale. We used multilevel ordered logistic regression to analyze the relationship between PWHS intensity and the four domains of the Centers for Disease Control’s HRQOL-4 (self-rated health, number of poor physical health days, number of poor mental health days, and activity limitation days during the past 30 days).

Results
In the sex- and age-adjusted and multivariate models, the intensity of PWHS significantly affected self-rated health and the three domains of unhealthy days (physical, mental, and activity limitation). There was also a trend toward worse HRQOL scores as the PWHS decreased.

Conclusions
We found that the higher the PWHS of Japanese workers, the higher their self-rated health and the fewer their unhealthy days. Companies need to assess workers’ PWHS and HRQOL and promote H&PM. H&PM is also necessary to maintain and promote the health of workers during the COVID-19 pandemic.
Near‐Infrared Responsive Membrane Nanovesicles Amplify Homologous Targeting Delivery of Anti‐PD Immunotherapy against Metastatic Tumors
Authors: Tan Ya‐Nan , Huang Jian‐Dong , Li Yong‐Peng , Li Shan‐Shan , Luo Min , Luo Jie , Lee Anne Wing‐Mui , Fu Li , Hu Fu‐Qiang , Guan Xin‐Yuan 
Published: December 2021

AbstractThe major obstacles of anti‐PD therapy in metastatic tumors are limited drug delivery in primary tumors and metastatic foci, and the lack of tumor‐infiltrating lymphocytes (TILs). Here, the authors constructed a novel cellular membrane nanovesicles platform (M/IR NPs) based on homologous targeting and near‐infrared (NIR) responsive release strategy to potentiate PD‐1/PD‐L1 blockade therapy against metastatic tumors. In tumor‐bearing mice, biomimetic M/IR NPs targeted both primary tumors and their lung metastases. Upon laser irradiation, M/IR NPs reduced cancer‐associated fibroblasts (CAFs) in tumor microenvironment, thus increasing the penetration of TILs. When shed from homologous tumor cell membranes, positively charged nanoparticles (IR NPs) core can capture released tumor‐associated antigens, thereby enhancing the antigen‐presenting ability of DCs to activate cytotoxic T lymphocytes. When the photothermal conversion temperature under NIR‐laser is higher than 42 °C, M/IR NPs initiated the rupture of cell membranes and the responsive release of PD‐1/PD‐L1 inhibitor BMS, which significantly attenuated tumor‐associated immunosuppression and synergistically induced T cellular immunity to inhibit the tumor growth and metastasis. Overall, biomimetic M/IR NPs can improve the targeting and therapeutic efficacy of anti‐PD therapy in primary tumors and metastases, opening up a new avenue for the diagnosis and treatment of metastatic tumors in the future.
Stable Quasi‐Solid‐State Aluminum Batteries
Authors: Huang Zheng , Song Wei‐Li , Liu Yingjun , Wang Wei , Wang Mingyong , Ge Jianbang , Jiao Handong , Jiao Shuqiang 
Published: December 2021

AbstractNonaqueous rechargeable aluminum batteries (RABs) of low cost and high safety are promising for next‐generation energy storage. With the presence of ionic liquid (IL) electrolytes, their high moisture sensitivity and poor stability would lead to critical issues in liquid RABs, including undesirable gas production, irreversible activity loss, and an unstable electrode interface, undermining the operation stability. To address such issues, herein, a stable quasi‐solid‐state electrolyte is developed via encapsulating a small amount of an IL into a metal–organic framework, which not only protects the IL from moisture, but creates sufficient ionic transport network between the active materials and the electrolyte. Owing to the generated stable states at both positive‐electrode–electrolyte and negative‐electrode–electrolyte interfaces, the as‐assembled quasi‐solid‐state Al–graphite batteries deliver specific capacity of ≈75 mA h g−1 (with positive electrode material loading ≈9 mg cm−2, much higher than that in the conventional liquid systems). The batteries present a long‐term cycling stability beyond 2000 cycles, with great stability even upon exposure to air within 2 h and under flame combustion tests. Such technology opens a new platform of designing highly safe rechargeable Al batteries for stable energy storage.