bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cross-Case Analysis of Developing Program Sustainability and Institutionalization in Early Stages of a Multisite Biomedical Student Diversity Initiative
Authors: Cobian Krystle Palma , Ramos Hector V. 
Published: February 2021

Abstract
Background: Grant funding often drives innovative programming in efforts to enhance diversity in biomedical fields, yet strategies for sustainability of grant-funded biomedical intervention are not well understood. Additionally, as funding agencies shift toward supporting institutional change to biomedical training, less is known about the extent to which sustainability strategies can support long-term institutionalization of the original goals of the grant-funded initiative. The purpose of this study is twofold: to identify strategies used by grant-funded programs for promoting sustainability, and to examine the interrelations between the concepts of sustainability and institutionalization during early stages of grant-funded biomedical career training efforts. Methods: We employed a multiple case study design and cross-case analysis using interviews of program administrators and participants from 10 undergraduate institutions that received Building Infrastructure Leading to Diversity (BUILD) awards funded by the National Institutes of Health (NIH).Results: BUILD sites engaged in the following strategies to develop program sustainability: 1) scaling and adapting to expand programmatic impact, 2) identifying additional funding and cost-cutting measures, 3) developing and maintaining infrastructure and structural operations, 4) leveraging relationships and with intra-and inter-institutional partners, and 5) and addressing hiring, policies, and reward systems at the institution. Senior administrative support supported program sustainability and early institutionalization, although we also identified situations where participants felt that they were on track for sustainable changes without administrative support or institutional change. Of the strategies identified, those that involve organizational and infrastructural changes contribute to early stages of institutionalization. Conclusions: This study provides evidence of distinctions and interrelations between program sustainability efforts and institutionalization of change efforts in that some programs employed sustainability strategies that also strived toward institutionalization. Findings indicate the importance of program administrators developing early sustainability plans that also lead to institutionalization, as well as an opportunity for funding agencies to develop technical assistance on sustainability, organizational change, and institutionalization as a resource to support program administrators’ efforts toward making lasting change on their campuses.
Safety, Pharmacokinetics, and Preliminary Efficacy of Talazoparib in Japanese Patients With Advanced Solid Tumors: Phase 1 Study
Authors: Naito Yoichi , Kuboki Yasutoshi , Ikeda Masafumi , Harano Kenichi , Matsubara Nobuaki , Toyoizumi Shigeyuki , Mori Yuko , Hori Natsuki , Nagasawa Takashi , Kogawa Takahiro 
Published: February 2021

Abstract
Background: Talazoparib is a poly(ADP-ribose) polymerase enzyme inhibitor. This open-label, non-randomized, phase 1 study of talazoparib investigated the safety, pharmacokinetics, and preliminary antitumor activity in Japanese patients with locally advanced or metastatic solid tumors, regardless of mutations in DNA damage repair-related genes, who are resistant to/ineligible for standard therapies.Methods: Patients received talazoparib dosed orally at 0.75 or 1 mg once daily using a modified 3+3 dose-escalation scheme. Primary endpoint was dose-limiting toxicities during the first cycle of talazoparib.Results: Nine patients (median age 62.0 years) were included: 3 and 6 patients at the 0.75 and 1.0 mg once-daily dose level, respectively. No dose-limiting toxicities were reported. The most commonly reported treatment-emergent adverse events (≥2 patients) were anemia, stomatitis, maculopapular rash, platelet count decreased, neutrophil count decreased, and alanine aminotransferase increased. Three patients had grade ≥3 treatment-emergent adverse events (anemia, brain metastases [1 patient each], and neutrophil and white blood cell count decreased [same patient]). Two patients temporarily discontinued treatment due to a treatment-emergent adverse event, and 1 patient required a dose reduction for neutrophil count decreased (all at 1 mg once daily). Talazoparib exposure (Cmax and AUC) after single and multiple dosing was slightly higher proportionally with talazoparib 1 mg than talazoparib 0.75 mg. The overall disease control rate was 44.4%, including 2 patients with stable disease. The recommended phase 2 dose of talazoparib was established as 1 mg once daily.Conclusions: Single-agent talazoparib was well tolerated and had preliminary antitumor activity in Japanese patients with advanced solid tumors. Clinical Trial Register: clinicalTrials.govClinical Registration Number: NCT03343054 (November 17, 2017)
Promoting Economic Growth and Environmental Sustainability Through Energy Efficiency: Evidence From Indonesia
Authors: Tenrini Rita Helbra , Damayanty Sofia Arie , Setyawan Dhani , Setiawan Hadi , Rakhmindyarto Rakhmindyarto 
Published: February 2021

Abstract
Indonesia has set a unilateral greenhouse gas emissions (GHG) emissions reduction target by 29% and conditional targets with international support of up to 41%, compared to the business as usual by 2030. This paper aims to formulate energy conservation policies to increase productivity and promote economic growth in Indonesia. Indonesia's energy conservation policy has multiple aspects: supporting energy security, commitment to GHG emission reduction, state budget efficiency, and improving productivity and competitiveness. Using Social Accounting Matrix (SAM), this study found evidence that energy efficiency saving will positively affect ecological sustainability and economic agents in the five targeted sectors: energy, waste, industrial processes, product use, agriculture, and forestry. Further, the Corporate Social Responsibility (CSR) policy provides positive effects in increasing economic growth and reducing income disparities.
Aging and MPTP-Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra
Authors: Abhilash PL , Bharti Upasna , Philip Mariamma , Rashmi Santhosh Kumar , Raju Trichur R , Kutty Bindu M , Sagar BK Chandrasekhar , Alladi Phalguni Anand 
Published: February 2021

Abstract
BackgroundBoth astroglia and microglia show region-specific distribution pattern in the central nervous system and often maladapt to age-associated alterations within their niche. Studies on autopsied substantia nigra of Parkinson’s disease (PD) patients and experimental models propose gliosis as a trigger for neuronal loss. Epidemiological studies propose an ethnic bias in PD prevalence, since Caucasians are more susceptible than non-whites living in Asia and Africa. Similarly, different mice strains are variably sensitive to the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). We had earlier likened divergent MPTP-sensitivity of C57BL/6J and CD-1 mice with differential susceptibility to PD, based on differences in neuronal numbers.MethodsHere we examined whether the variable susceptibility was also incumbent to inter-strain differences in the glial features in the substantia nigra pars compacta (SNpc) of C57BL/6J and CD-1 mice. We performed unbiased stereology to quantify iba-1 immunoreactive microglia and s100β immunopositive astroglia on immunohistochemically stained sections. Further, ELISA based estimation of pro- inflammatory and anti-inflammatory cytokines was supplemented with estimation of enzymes like fractalkine, hemeoxygenase, and monoamine oxidases A and B. Electron microscopy was performed to compare the effects on the organelles.ResultsStereological counts showed more microglia and fewer astrocytes in the substantia nigra of MPTP-susceptible normal C57BL/6J mice, which suggests persistence of an immune-vigilant state. MPTP caused induction of microgliosis and astrogliosis in both strains, suggesting the involvement of these cells in pathogenesis. ELISA of pro-inflammatory cytokines in the ventral-midbrain revealed augmentation of TNF-α and IL-6 at middle-age in both strains that reduced at old-age, suggesting middle-age as a critical, inflamm-aging associated time-point. TNF-α levels were persistently high in C57BL/6J, through aging and post-MPTP; while IL-6 and IL-1β were upregulated at old-age. CD-1 had higher levels of anti-inflammatory cytokine TGF-β. MPTP-challenge caused upregulation of enzymes MAO-A, MAO-B and iNOS in both strains. Post-MPTP enhancement in fractalkine and hemeoxygenase-1, may be neuronal compensatory signals. Lastly, ultrastructural observations of elongated mitochondria in astroglia and microglia vis-à-vis the shrunken ones in neurons, suggest upscaling of their functions with neurotoxic consequences.ConclusionsThus, astroglia and microglia play a critical role in modulating aging and the susceptibility of an individual to PD.
Novel Variants in DNAH9 Lead to Nonsyndromic Severe Asthenozoospermia
Authors: Tang Dongdong , Sha Yanwei , Gao Yang , Zhang Jingjing , Cheng Huiru , Zhang Junqiang , Ni Xiaoqing , Wang Chao , Xu Chuan , Geng Hao , He Xiaojin , Cao Yunxia 
Published: February 2021

Abstract
Background Asthenozoospermia is one of the most common causes of male infertility, and its genetic etiology is poorly understood. DNAH9 is a core component of outer dynein arms in cilia and flagellum. It was reported that variants of DNAH9 (OMIM: 603330) might cause primary ciliary dyskinesia (PCD). However, variants in DNAH9 lead to nonsyndromic severe asthenozoospermia have yet to be reported.Methods Whole exome sequencing (WES) was performed for two individuals with nonsyndromic severe asthenozoospermia from two non-consanguineous families, and Sanger sequencing was performed to verify the identified variants and parental origins. Sperm routine analysis, sperm vitality rate and sperm morphology analysis were performed according the WHO guidelines 2010 (5th edition). Transmission electron microscopy (TEM, TECNAI-10, 80 kV, Philips, Holland) was used to observe ultrastructures of sperm tail. Quantitative realtime-PCR and immunofluorescence staining were performed to detect the expression of DNAH9-mRNA and location of DNAH9-protein. Furthermore, assisted reproductive procedures were applied.Results By WES and Sanger sequencing, compound heterozygous DNAH9 (NM_001372.4) variants were identified in the two individuals with nonsyndromic severe asthenozoospermia (F1 II-1: c.302dupT, p.Leu101fs*47 / c.6956A>G, p.Asp2319Gly; F2 II-1: c.6294T>A, p.Phe2098Leu / c.10571T>A, p.Leu3524Gln). Progressive rates less than 1% with normal sperm morphology rates and normal vitality rates were found in both of the two subjects. No respiratory phenotypes, situs inversus or other malformations were found by detailed medical history, physical examination and lung CT scans etc. Moreover, the expression of DNAH9-mRNA was significantly decreased in sperm from F1 II-1. And expression of DNAH9 is lower in sperm tail by immunofluorescence staining in F1 II-1 compared with normal control. Notably, by intracytoplasmic sperm injection (ICSI), F1 II-1 and his partner successfully achieved clinical pregnancy. Conclusions We identified DNAH9 as a novel pathogenic gene for nonsyndromic severe asthenospermia, and ICSI can contribute to favorable pregnancy outcomes for these patients.
Women's Knowledge and Attitude Towards Cervical Cancer Preventive Measures and Associated Factors in South Gondar Zone, Amhara Region, North Central Ethiopia: a Cross-sectional Study
Authors: Tafere Yilkal , Jemere Tezera , Desalegn Tsion , Melak Addisu 
Published: February 2021

Abstract
Background: The aim of the current research was to assess women's knowledge and attitudes towards cervical cancer preventions in South Gondar zone. Methods: A community-based cross-sectional study was carried out in South Gondar zone, Ethiopia. A total of 844 women aged 18 and above have participated in the current study. Binary and multivariable logistic models were used to assess predictors of women’s knowledge and attitude towards cervical cancer.Results: About 66% of the women had heard about cervical cancer. The percentage of women who heard about cervical cancer was 66%. Regarding the main source of information of respondents, 75.4% were heard from health professionals. Sixty two point four percent of women knew at least one preventive measure and 82.6% of participants knew at least one symptom or sign. Among study participants, 25% and 64% had good knowledge, and favorable attitude towards cervical cancer prevention measures, respectively. Being reside in rural (AOR= .21, 95%CI; .18, .34), not attending formal education (AOR = 0.50, 95% CI: 0.3, 0.75), low income (AOR = .57, 95% CI: .43, .81) and having <4 children ((AOR = .8, 95% CI: .60–.86) were negatively associated with knowledge toward cervical cancer prevention measures Conclusion: This study found the majority of the respondents had poor knowledge about cervical cancer prevention measures. The majority of the study participants had favorable attitudes regarding cervical cancer prevention. Living in rural areas, not attending any formal education low income and having less than four children was negatively associated with respondents' knowledge towards cervical cancer prevention measures. There is needed to scale up cervical cancer prevention measures and services
Swarm Shedding in Networks of Self-propelled Agents
Authors: Hindes Jason , Edwards Victoria , Kasraie Klimka Szwaykowska , Stantchev George , Schwartz Ira B. 
Published: February 2021

Abstract
Understanding swarm pattern-formation is of great interest because it occurs naturally in many physical and biological systems, and has artificial applications in robotics. In both natural and engineered swarms, agent communication is typically local and sparse. This is because, over a limited sensing or communication range, the number of interactions an agent has is much smaller than the total possible number. A central question for self-organizing swarms interacting through sparse networks is whether or not collective motion states can emerge where all agents have stable and coherent dynamics. In this work we introduce the phenomenon of swarm shedding in which weakly-connected agents are ejected from stable milling patterns in self-propelled swarming networks with finite-range interactions. We show that swarm shedding can be localized around a few agents, or delocalized, and entail a simultaneous ejection of all agents in a network. Despite the complexity of milling motion in complex networks, we successfully build mean-field theory that accurately predicts both milling state dynamics and shedding transitions. The latter are described in terms of saddle-node bifurcations that depend on the range of communication, the inter-agent interaction strength, and the network topology.
Analysis of Hepatocellular Carcinoma Stereotactic Body Radiation Therapy Dose Prescription Method Using Uncomplicated Tumour Control Probability Model
Authors: Cheung Michael L M , Kan Monica W K , Chan Anthony T C 
Published: February 2021

Abstract
Background: This work was to establish an uncomplicated tumour control probability (UTCP) model using Hepatocellular Carcinoma Stereotactic Body Radiation Therapy (HCC SBRT) clinical data in our institution. The model was then used to analyze the treatment outcome of the current dose prescription method and to seek the opportunity for improvement.Methods: A tumour control probability (TCP) model was generated based on local clinical data using the maximum likelihood method. A UTCP model was then formed by combining the established TCP model with the normal tissue complication probability (NTCP) model based on the study by Dawson et al. The authors investigated the dependence of maximum achievable UTCP on tumor mean biological effective dose (BED) at various ratio between tumour mean biological effective dose (BED) and normal liver mean BED (T/N BED ratios). A new term uncomplicated tumour control efficiency (UTCE) was also introduced to analyze the outcome. A UTCE value of 1 implied that the theoretical maximum UTCP for the corresponding T/N BED ratio was achieved.Results: The UTCE of the HCC SBRT patients based on the current dose prescription method was found to be 0.90±0.08. It was found that the UTCE could be increased to 0.99±0.03 by using a new dose prescription scheme, for which the UTCP could be maximized while keeping the NTCP value smaller than 5 %. Conclusion: The treatment outcome of the current HCC SBRT in our institution was analyzed using a UTCP model established based on local clinical data. It was shown that there could be a potential to increase the prescription dose of HCC SBRT. A new dose prescription scheme was proposed to achieve better treatment outcome.
Safety of Radiotherapy in Patients with Cardiac Implantable Electronic Devices
Authors: Han Donghoon , Lee Ji Hyun , Cho Youngjin , Oh Il-Young 
Published: February 2021

Abstract
Background: Patients with cardiac implantable electronic devices (CIEDs) usually have multiple comorbidities, and some require radiotherapy (RTx) for cancer treatment. However, the effect of RTx in patients with CIEDs is unclear. We aimed to examine the effectiveness of RTx in patients with CIEDs, and share our real-world clinical experience in this population.Methods: We recruited patients with a pacemaker or implantable cardioverter-defibrillator who underwent RTx between April 2009 and August 2019. RTx and CIED interrogation data were collected from electronic medical records. Patients who received an RTx cardiology consultation and CIED interrogation before and after RTx were assigned to the proper consultation (PC) group. All others were enrolled in the no-consultation (NC) group. Results: Out of 23 patients, 3 (13.0%) and 20 (87.0%) patients were assigned to the PC and NC groups, respectively. The most common RTx sites were the abdomen and pelvis (34.8%). The mean cumulative dose was 50.1 ± 11.7 Gy, and the mean beam energy was 10.3 ± 4.01 mV. The PC and NC groups showed no significant difference in cumulative dose (51.5 ± 12.1 vs. 45.3 ± 3.9, p=0.19) or beam energy (10.4 ± 4.03 vs. 7.0 ± 1.41, p=0.08). There was no significant between-group difference in any pre-RTx CIED parameter. Two patients died during the study period; both were in the NC group. The relationship between death and device malfunction was not clear in either case.Conclusions: Patients with CIEDs frequently do not receive a cardiology consultation before RTx. Although radiotherapy-related CIED complications occur stochastically and are difficult to predict, cooperation between the cardiology and radiation therapy departments, and regular device follow-up are necessary for the safety of these patients.
Neoadjuvant Chemoradiotherapy in Patients With Unresectable Locally Advanced Sigmoid Colon Cancer: Clinical Feasibility and Outcome
Authors: Niu Shao-Qing , Li Rong-Zhen , Yuan Yan , Xie Wei-Hao , Wang Qiao-Xuan , Chang Hui , Lu Zhen-Hai , Ding Pei-Rong , Li Li-Ren , Wu Xiao-Jun , Zeng Zhi-Fan , Xiao Wei-Wei , Gao Yuan-Hong 
Published: February 2021

Abstract
Background: Patients with locally advanced sigmoid colon cancer (LASCC) have limited treatment options and a dismal prognosis with poor quality of life. This prospective study aimed to further evaluate the feasibility and efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by surgery as treatment for select patients with unresectable LASCC.Methods: We studied patients with unresectable LASCC who received NACRT between November 2010 and April 2019. The NACRT regimen consisted of intensity modulated radiotherapy (IMRT) of 50 Gy to the gross tumor and positive lymphoma nodes and 45 Gy to the clinical target volume. Capecitabine‑based chemotherapy was administered every 3 weeks. Surgery was scheduled 6–8 weeks after radiotherapy.Results: Seventy‑two patients were enrolled in this study. Patients had a regular follow-up (median, 41.1 months; range, 8.3–116.5 months). Seventy‑one patients completed NACRT, and sixty-five completed surgery. Resection with microscopically negative margins (R0 resection) was achieved in 64 patients (88.9%). Pathologic complete response was observed in 15 patients (23.1%), and multivisceral resection was necessary in 38 patients (58.3%). The cumulative probability of 3-year overall survival and disease‑free survival were 75.8% and 70.7%, respectively.Conclusion: For patients with unresectable LASCC, neoadjuvant chemoradiotherapy is feasible, surgery can be performed safely and may result in increased survival and organ preservation rates.
Family-centered Approach to Monitoring Children’s Development in a Paediatric Outpatient Setting: Feasibility Study From Pakistan
Authors: Rasheed Muneera A. , Mughis Waliyah , Elahi Kinza N , Hasan Babar S. 
Published: February 2021

Abstract
Background: The purpose of the study was to design and test the feasibility of a recent guideline of family-centered psychosocial support as an approach to developmental monitoring in a pediatric outpatient setting.Methods: The patient experience team at a private tertiary care hospital leveraged an on-going patient and family-centric initiative in the service to implement the intervention. The intervention delivery model was designed using the theory of change model and entailed the following i) the service providers: paediatricians but with support from psychology trainee volunteers to address time constraints; ii) monitoring form: Survey of Well-Being of Young Children (SWYC) being feasible and designed for regular developmental monitoring as parent report; iii) family support intervention: the Care for Child Development module to enhance parent-child interactions given team’s successful experience with inpatient children; iv) timing: utilize wait time to also enhance families’ experience and v) reinforcement: reinforced by the paediatrician in the consultation visit to capitalize on the established rapport and relationship with families. All families with children under 5 years 5 months of age in selected clinics (acute care, complex care, developmental issues) were eligible. The study was evaluated for acceptability and implementation feasibility. Families were interviewed about their experience; trainees provided a written narrative while physicians provided feedback on email. These were thematically analyzed using an inductive approach.Results: A total 182 families were administered the SWYC with 54% children detected for further review on cognitive milestones and 76% on social-emotional milestones. Forty-eight families were interviewed regarding their experience with the intervention. They reported the monitoring process to be useful and important for them as parents indicating acceptability. Paediatricians and trainees found the intervention to be important for parents and children’s health also requesting further understanding about child’s functioning. The trainees further expressed the experience to be significant for their own learning.Conclusion: The authors conclude that the intervention model for a family-centric approach to monitoring was acceptable to the families and the service providers. The intervention when implemented using a robust behaviour change framework can enhance feasibility.