bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid Metabolism and Mitochondria: Cross Talk in Cancer
Authors: Srivastava Anubhav , Srivastava Pransu , Mathur Shashank , Abbas Sabiya , Rai Neeraj , Tiwari Swasti , Tiwari Meenakshi , Sharma Lokendra 
Published: August 2021

:
Metabolic reprogramming is considered a major event in cancer initiation, progression
and metastasis. The metabolic signature of cancer cells includes alterations in glycolysis, mitochondrial
respiration, fatty acid/lipid and amino acid metabolism. Being at a junction of various
metabolic pathways, mitochondria play a key role in fueling cancer growth through regulating
bioenergetics, metabolism and cell death. Increasing evidence suggests that alteration in lipid
metabolism is a common feature of metastatic progression, including fatty acid synthesis as well as
fatty acid oxidation. However, the interplay between lipid metabolism and mitochondria in carcinogenesis
remains obscure. The present review focuses on key lipid metabolic pathways associated
with mitochondrial regulation that drive cancer phenotype and metastasis. We also review potential
targets of lipid metabolism and mitochondria to improve the therapeutic regime in cancer patients.
This review aims to improve our current understanding of the intricate relation of lipids with mitochondria
and provides insights into new therapeutic approaches.
Thromboprophylaxis in Patients with COVID-19: Systematic Review of National and International Clinical Guidance Reports
Authors: Kyriakoulis Konstantinos G. , Kollias Anastasios , Kyriakoulis Ioannis G . , Kyprianou Ioanna A. , Papachrysostomou Chrysso , Makaronis Panagiotis , Kotronias Rafail A. , Terentes-Printzios Dimitrios , Toskas Ioannis , Mikhailidis Dimitri P. 
Published: August 2021

Background:
Venous thromboembolism (VTE) is common among patients with severe
coronavirus disease 2019 (COVID-19). Anticoagulation in hospitalized COVID-19 patients has
been associated with survival benefit; however, the optimal thromboprophylaxis strategy has not
yet been defined.

Objective:
To identify published guidance reports by national and international societies regarding
thromboprophylaxis strategies in COVID-19 patients in different settings (outpatients, hospitalized,
post-discharge).

Methods:
A systematic review of the literature (Pubmed/EMBASE) was conducted independently
by two investigators.

Results:
Among 1942 initially identified articles, 33 guidance documents were included: 20 published
by national and 13 by international societies. These documents provide recommendations
mainly for hospitalized (97% of reports) and post-discharge (75%) COVID-19 patients, and less so
for outpatients (34%). Thrombotic and bleeding risk stratification prior to any treatment decision is
the cornerstone of all suggested thromboprophylaxis strategies; 81% of the documents recommend
thromboprophylaxis for all hospitalized patients with a prophylactic dosage of low molecular
weight heparin irrespective of VTE risk. Intermediate or therapeutic dose intensity is recommended
in high VTE risk patients by 56% and 28% of documents, respectively. Mechanical thromboprophylaxis
is suggested in case of high bleeding risk or contraindication to pharmacological thromboprophylaxis
(59% of documents). Extended pharmacological thromboprophylaxis is recommended
for patients with high VTE risk after hospital discharge (63% of documents). For non-hospitalized
outpatients, 28% of documents recommend pharmacological thromboprophylaxis for high VTE
risk.

Conclusion:
The current guidance identifies thromboprophylaxis in COVID-19 patients, especially
during hospitalization, as of major importance for the prevention of VTE. Recommendations are derived
from limited evidence from observational studies.
Wogonin Induces Cell Cycle Arrest and Apoptosis of Hepatocellular Carcinoma Cells by Activating Hippo Signaling
Authors: Ding Yanbing , Shen Weigan , Wu Keyan , Teng Man , Zhou Wei , Lu Fanglin , Zhou Yang , Zeng Jing , Yang Jie , Liu Xinnong , Zhang Yu 
Published: August 2021

Objective:
Wogonin has been reported to exhibit pharmacological effects against cancer by regulating
cell proliferation, metastasis and apoptosis, however, the role of wogonin in hepatocellular carcinoma (HCC) remains
poorly elucidated.

Objective:
The current study aimed to illustrate whether wogonin influences HCC cell cycle progression and apoptosis
by regulating Hippo signaling.

Methods:
The effects of wogonin on HCC cell viability, cell cycle progression and apoptosis were analyzed by utilizing
CCK-8 and flow cytometry. RNA-seq was employed to analyze the expression profiles between wogonin-treated
and control HCC cells, and the selected RNA-seq transcripts were validated by Reverse Transcription-quantitative realtime
Polymerase Chain Reaction (RT-qPCR). Immunofluorescence staining was performed to detect the distribution of
YAP/TAZ in the nucleus and cytoplasm in HCC cells. Western blotting and human apoptosis array were performed to
examine the expression of the indicated genes.

Results:
We demonstrated that wogonin induced cell cycle arrest and apoptosis of HCC cell lines SMMC7721 and
HCCLM3. RNA-seq analysis showed enrichment in genes associated with cell cycle progression and apoptosis following
incubation with wogonin in HCC cells, and the pathways analysis further identified that Hippo signaling pathways
highly altered in wogonin-treated cells. Specifically, wogonin increased the phosphorylation of MOB1 and LATS1,
promoted translocation of endogenous YAP and TAZ from the nucleus to the cytoplasm, and facilitated phosphorylation
of YAP and TAZ. Notably, overexpression of YAP or TAZ partially abrogated the wogonin-mediated HCC cell
cycle arrest and apoptosis, and reversed wogonin-mediated suppression of Claspin.

Conclusion:
Wogonin induced HCC cell cycle arrest and apoptosis probably by activating MOB1-LATS1 signaling to
inhibit the activation of YAP and TAZ, and then decrease the expression of Claspin, suggesting that the understanding
of the molecular mechanisms underlying wogonin-induced cell cycle arrest and apoptosis may be useful in HCC therapeutics.
Corrigendum to: Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian Population: A Case-Control Study
Authors: Bakhtiyari Amin , Haghani Karimeh , Bakhtiyari Salar , Zaimy Mohammad A. , Zahed Nooriali , Gheysarzadeh Ali , Nahalkhani Seidali , Darabi Shahram , Amraei Mansour , Alipourfard Iraj 
Published: August 2021

Due to oversight on the part of the authors, the names of two of the co-authors have been incorrectly published in the article
entitled, “Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian
Population: A Case-Control Study”, 2021, Vol. 21, No. 3, pp. 441-447 [1].

The original article can be found online at: https://doi.org/10.2174/1871530320666200713091827.

Original:
Amin Bakhtiyari, Karimeh Haghani, Salar Bakhtiyari*, Mohammad A. Zaimy, Nooriali Zahed, Ali Gheysarzadeh, Shahram
Darabi, Seidali Nahalkhani, Mansour Amraei and Iraj Alipourfard

Corrected:
Amin Bakhtiyari, Karimeh Haghani, Salar Bakhtiyari*, Mohammad A. Zaimy, Ali Noori-Zadeh, Ali Gheysarzadeh, Shahram
Darabi, Ali Seidkhani-Nahal, Mansour Amraei and Iraj Alipourfard
Risk Factors of SARS-CoV-2 Infection: Global Epidemiological Study
Authors: Barletta William Alphonse 
Published: August 2021

BackgroundSince the first recognition of the pandemic characteristics of SARS-CoV-2 infection, and before substantial case fatality data were available worldwide, public health agencies warned the public about the increased dangers of SARS-CoV-2 to persons with a variety of underlying physical conditions, many of which are more commonly found in persons over 50 years of age or in certain ethnic groups.ObjectiveTo investigate the statistical rather than the physiological basis in support of the abovementioned warnings, this study examines correlations globally on a nation-by-nation basis between the statistical data concerning COVID-19 fatalities and the statistics of potential comorbidities that may influence the severity of infection.MethodsThis study considers the statistics describing the populations of the 99 countries with the greatest numbers of SARS-CoV-2 infections at the time of the data cutoff. As national compilations of direct measures of immune system strength are not publicly available, the frequency of fatalities in those countries due to a variety of serious diseases is used as a proxy for the susceptibility of those populations to those same diseases.ResultsThe analysis produces plots and calculations of correlations and cross-correlations of COVID-19 case fatality rates and the risks of other potential cofactors. It exposes some reasons that may underlie the degree to which advanced age increases the risk of mortality of infection with SARS-CoV-2. In contrast with the strong influences of comorbidities on the seriousness of consequences of influenzas and their associated pneumonias, the correlations of the same set of risk factors with SARS-CoV-2 infection are considerably weaker. The general characteristics of the observed correlations strengthened through 3 cycles of analysis, starting in September 2020. The strongest correlations were with chronic kidney disease and coronary disease (approximately 0.28 and 0.20, respectively).ConclusionsThis study confirms early clinical observations that infection with SARS-CoV-2 presents an increased risk to persons over the age of 65 years. It does not support the suggestions presented by government agencies early in the pandemic that the risks are much greater for persons with certain common potential comorbidities.
Diálisis Peritoneal en tiempos difíciles.
Authors: Uribe Betancur José Mauricio , Molano Triviño Alejandra Patricia 
Published: August 2021

La Diálisis Peritoneal es una terapia igual o superior a la hemodiálisis, es costo-efectiva y ha permitido el soporte dialítico vital a poblaciones víctimas de desastres naturales. En las actuales circunstancias de pandemia y aislamiento social por el COVID 19, la diálisis peritoneal, al ser una terapia domiciliaria, reduce los riesgo de exposición para pacientes, cuidadores y equipos de atención, sin embargo, es una terapia subutilizada a nivel global. Al mostrar los beneficios de la diálisis peritoneal sobre la hemodiálisis y los desenlaces de esta en tiempos de desastre, se presenta como la mejor alternativa para estos tiempos de pandemia. Se llevó a cabo una revisión no sistemática de la literatura, en busca de los beneficios de la diálisis peritoneal vs hemodiálisis y sus desenlaces en situaciones de calamidad. En esta se incluyeron 75 artículos publicados entre1993 y marzo del 2020. Estos estudios muestran los múltiples beneficios de la diálisis peritoneal sobre la hemodiálisis y ser la mejor alternativa en situaciones de desastre. Por lo anterior concluimos que la diálisis peritoneal tiene significativos beneficios sobre la hemodiálisis, entre estos una mayor supervivencia, especialmente en los dos primeros años, una menor velocidad en la tasa de perdida de la función renal residual, permite preservar los accesos vasculares, hay mayor supervivencia post trasplante, además de ser más económica y en situaciones de desastres naturales, como lo es esta pandemia, ha facilitado la continuidad de la atención y el soporte dialítico agudo o crónico para las víctimas.
Testbed for Sub-Nyquist Wideband Spectrum Monitoring
Authors: Medina Lee Juan Felipe , López-Parrado Alexander , Vera Tasamá Alexander , Bohórquez Palacio Duvier de Jesús 
Published: August 2021

Radioelectric spectrum management is a concern for today’s world, mainly due to the misuse that has been given to this resource through the years, especially on the UHF band. To address this problem, a testbed for sub-Nyquist Wideband Spectrum Monitoring was built, that includes a web interface to remotely measure occupancy of the UHF band.
To achieve the above, an RF interface that allows tuning UHF frequencies with an instantaneous bandwidth of 95 MHz was built. Afterwards, a Random Demodulator was connected, and then an embedded system performed sub--Nyquist sampling and spectrum recovery. The embedded system connected to an information system that serves a web page, through which remote users can perform UHF band monitoring.
Experimental results showed that spectrum sensing can be achieved by using different algorithms on certain sparse spectra. In addition, the aforementioned web interface allowed simultaneous user connections, in order to perform independent measurements by sharing a hardware subsystem.
Gestão de Pessoas e Inovações Gerenciais: um Estudo Baseado em Cognições de Gestores
Authors: Mara Rosalia Ribeiro Silva  , Ana Paula Moreno Pinho  
Published: August 2021

Objetivos do estudo: Analisar a percepção de gestores acerca da relação entre práticas de gestão de pessoas (GP) e a implementação de inovações gerenciais, a partir das cognições de gestores. Metodologia/abordagem: Com abordagem qualitativa, foram ouvidos 16 gestores por meio de entrevistas semiestruturadas, com auxílio da “técnica das fichas”. Foi realizada a análise de conteúdo. Principais resultados: As práticas de GP atuam como facilitadoras das inovações gerenciais implementadas pelos gestores. “Envolvimento de pessoas” e “treinamento, desenvolvimento e educação” foram práticas percebidas como as mais relevantes para a implementação de inovações gerenciais, e “recompensas” foi a menos relevante. Contribuições acadêmicas: Este artigo contribui com o campo da GP estratégica, no sentido de que, quando a GP estabelece um planejamento de longo prazo alinhado aos objetivos organizacionais e implementa práticas específicas de gestão, isto colabora para com a geração e implementação de inovações gerenciais. As inovações gerenciais foram colocadas em evidência, buscando esclarecer a concepção dos gestores e obtendo principais exemplos de práticas e processos inovadores executados por eles. Destaca-se a contribuição metodológica com o uso da “técnica das fichas”, enquanto alternativa para o campo dos estudos organizacionais na compreensão das cognições gerenciais. Contribuições práticas: Este estudo oferece à GP estratégica informações para que os gestores invistam em um planejamento estratégico com vistas a priorizar as práticas percebidas como mais relevantes para a implementação de inovações gerenciais, além de incrementar e remodelar aquelas percebidas como menos relevantes.
Palavras-chaves: Inovações gerenciais. Práticas de gestão de pessoas. Cognições gerenciais.
Cybersports sphere organization peculiarities in educational space of higher education institution in forming student sports competences
Authors: Khairullina Elmira R. , Solonin Mikhail A. , Ovchinnikov Oleg M. , Bogdanova Venera I. , Slepneva Elena V. , Shubovich Valery G. 
Published: August 2021

The article reveals the modern understanding of the discursive content of the cybersport sphere and identifies its priorities in the educational space of the university. It establishes the structure and content of eSports competences’ types determined by the students’ social roles in the cybersports sphere of higher education institution’s educational space. Based on the results of the study, the authors justified an interactive model of cybersports sphere organization as a priority condition for the formation of eSports competences of students' socialization in the educational space of the university. The effectiveness of the model has been proven by the results of the implementation of the cybersport sphere in the educational space of the university.
PENGARUH MODEL PEMBELAJARAN RECIPROCAL TEACHING TERHADAP PRESTASI BELAJAR DAN KEMAMPUAN BERFIKIR KREATIF MATEMATIKA
Authors: Alghufron Ibnu Rizal , Paridjo Paridjo , Rokhman Moh. Saefur 
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan : (1) prestasi belajar matematika yang diajarkan menggunakan model pembelajaran Reciprocal Teaching lebih baik daripada yang diajarkan menggunakan model pembelajaran ekspositori, (2) kemampuan berfikir kreatif matematika yang diajarkan menggunakan model pembelajaran Reciprocal Teaching lebih baik daripada yang diajarkan menggunakan model pembelajaran ekspositori, (3) ada perbedaan prestasi belajar dan kemampuan berfikir kreatif matematika yang diajarkan menggunakan model pembelajaran Reciprocal Teaching dengan yang diajarkan menggunakan model pembelajaran ekspositori (4) ada pengarauh model pembelajaran Reciprocal Teaching terhadap prestasi belajar dan kemampuan berfikir kreatif matematika. Populasi dalam penelitian ini adalah peserta didik kelas VIII semester II SMP Negeri 1 Kedungbanteng Tahun Pelajaran 2016/2017. Pengambilan sampel menggunakan teknik cluster random sampling. Sampel yang diambil sebanyak 5 kelas yaitu dua kelas sebagai kelas eksperimen, dua kelas sebagai kelas kontrol, dan satu kelas sebagai kelas uji coba. Teknik pengumpulan data yang digunakan adalah dokumentasi dan tes. Instrumen penelitian berupa tes yang telah teruji validitas dan reliabilitas pada taraf signifikansi 5%. Analisis data menggunakan uji t satu pihak kanan, manova, dan Uji -Hotelling. Hasil penelitian menunjukan bahwa : (1) prestasi belajar peserta didik yang diajar menggunakan model pembelajaran Reciprocal Teaching lebih baik daripada peserta didik yang diajarkan menggunakan model pembelajaran ekspositori, (2) kemampuan berfikir kreatif matematika peserta didik yang diajar menggunakan model pembelajaran Reciprocal Teaching lebih baik daripada peserta didik yang diajarkan menggunakan model pembelajaran ekspositori, (3) ada perbedaan prestasi belajar dan kemampuan berfikir kreatif matematika peserta didik yang diajar menggunakan model pembelajaan Reciprocal Teaching dengan yang diajarkan menggunakan model pembelajaran ekspositori, (4) ada pengaruh model pembelajaran Reciprocal Teaching terhadap prestasi belajar dan kemampuan berfikir kreatif matematika peserta didik kelas VIII semester II SMP Negeri 1 Kedungbanteng tahun pelajaran 2016/2017
The radiological finding of chronic malrotation in a 12-year-old child with omphalocele and liver herniation: a case report and literature review
Authors: Bhinder Khurram Khaliq , Sarfraz Zouina , Sarfraz Azza , Tebha Sameer Saleem , Afsar Nasir Ali 
Published: August 2021

Background:
Malrotation of the intestines is an uncommon pediatric condition that typically presents in the first month of life.

Case Presentation:
Using the SCARE 2020 Guidelines, we report a case of a 12-year-old female with omphalocele and bilobed liver herniation presenting with chronic intestinal malrotation. A computed tomography of the abdomen and pelvis with IV contrast revealed a peritoneal defect measuring 4 cm in the upper abdomen, containing the gut including pylorus, duodenum while retrospective distension of the stomach was seen up to the pylorus. The open Ladd’s procedure was performed to correct the defect. No complications were noted intra-or 1 month post-operatively. Patients with intestinal malrotation may present with abdominal pain, intestinal obstruction, nausea, or vomiting. Conclusion: The open Ladd’s procedure was deemed safe, feasible, and effective in a resource limited country like Pakistan, in the treatment of young children with intestinal malrotation.
Analysis of Risk Factors for Postoperative Delirium in Patients with Esophageal Cancer
Authors: Zhang Menglu , Bai Xiaozhi , Zhang Yuting , Xie Xiaojuan 
Published: August 2021

Objective — To investigate the occurrence and risk factors of postoperative delirium in patients with esophageal cancer. Methods — A review of 203 patients undergoing elective surgery for esophageal cancer from April 2019 to December 2020, including 122 males and 81 females. The incidence of postoperative delirium were evaluated through the use of the CAM and divided into delirium group (Group P) and non-delirium group (Group N) according to whether postoperative delirium occurred. Possible confounders and clinically important factors were included in the univariate analysis, and all variables with P-values less than 0.05 in the univariate analysis were included in the multivariate models. Results — A total of 38 cases (18.7%) of postoperative delirium occurred in 203 patients. Group P was significantly older than Group N (P=0.000<0.01). The Patient Health Questionnaire 9 (PHQ-9) scores (P=0.01<0.05) and the FRAIL Scale scores of Group P were significantly higher than those of the N group (P=0.001<0.05). The educational level (P=0.001<0.01) and Mini-Mental State Examination (MMSE) scores (P=0.004<0.01) of Group P were significantly lower than those of Group N. The use rate of sevoflurane in Group P (P=0.011<0.05), the incidence of intraoperative hypotension (P=0.002<0.05), and the rate of Porphyromonas gingivalis infection (P=0.012<0.05) were higher than those in Group N. Multivariate logistic regression analysis showed that age (OR=1.295, 95%CI 1.125 ~ 1.490) and Porphyromonas gingivalis infection (OR=2.898, 95%CI 1.055 ~ 7.959) were independent risk factors for postoperative delirium in patients with esophageal cancer. Conclusion — age and Porphyromonas gingivalis infection may be the independent risk factors for postoperative delirium in patients with esophageal cancer.
PERLAWANAN RAKYAT WANGI-WANGI TERHADAP KEBIJAKAN PENARIKAN PAJAK PEMERINTAH HINDIA BELANDA PADA AWAL ABAD XX
Authors: Lina Nurvianti , Hadara Ali , Hayari Hayari 
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan proses perlawanan rakyat Wangi-Wangi terhadap kebijakan penarikan pajak pemerintah Hindia Belanda pada awal abad XX. Metode yang digunakan dalam penelitian ini adalah metode sejarah yang terdiri atas lima tahapan kerja yaitu, (1) Pemilihan topik, (2) Heuristik sumber, (3) Verifikasi sumber, (4) Interpretasi sumber, (5) Historiografi. Hasil penelitian menunjukkan bahwa: (1) Perlawanan rakyat Wangi-Wangi terhadap kebijakan penarikan pajak dimulai sejak penandatanganan perjanjian Asyikin-Brugman pada tahun 1906. Pada saat itu wilayah Kesultanan Buton direstrukturisasi ke dalam sistem distric. Salah satu distrik tersebut yakni distrik Wanci yang ada di Pulau Wangi-Wangi. Masyarakat melakukan perlawanan karena menganggap mekanisme pemungutan pajak yang kurang etis secara adat. (2) Proses Perlawanan rakyat Wangi-Wangi terhadap kebijakan penarikan pajak pemerintah Hindia Belanda dimulai pada masa akhir pemerintah Hindia Belanda. Perlawanan rakyat Wangi-Wangi juga dilakukan secara tidak langsung yaitu dengan cara melarikan diri dari besarnya jumlah pajak, bahkan rakyat yang tidak tahan terpaksa melarikan diri dari daerah tersebut. (3) Dampak perlawanan rakyat Wangi-Wangi terhadap kebijakan penarikan pajak dibagi menjadi dua yaitu: dampak negatif dan dampak positif. Dampak negatif yakni masyarakat hidup dalam kemiskinan dan kemeralatan. Dampak positif yakni aksi perlawanan tersebut berhasil menyalakan semangat patriotik di dalam dada seluruh rakyat Wangi-Wangi untuk memperjuangkan kemerdekaannya.