bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Influences of Gravitoinertial Force Level and Visual Field Pitch on Visually Perceived Eye Level
Authors: DiZio Paul , Li Wenxun , Lackner James R. , Matin Leonard 
Published: September 2021

Psychophysical measurements of the level at which observers set a small visual target so as to appear at eye level (VPEL) were made on 13 subjects in 1.0 g and 1.5 g environments in the Graybiel Laboratory rotating room while they viewed a pitched visual field or while in total darkness. The gravitoinertial force was parallel to the z-axis of the head and body during the measurements. The visual field consisted of two 58° high, luminous, pitched-from-vertical, bilaterally symmetric, parallel lines, viewed in otherwise total darkness. The lines were horizontally separated by 53° and presented at each of 7 angles of pitch ranging from 30° with the top of the visual field turned away from the subject (top backward) to 30° with the top turned toward the subject (top forward). At 1.5 g, VPEL changed linearly with the pitch of the 2-line stimulus and was depressed with top hackward pitch and elevated with top forward pitch as had been reported previously at 1.0 g (1.2): however, the slopes of the VPEL-vs-pitch functions at 1.0 g and 1.5 g were indistinguishable. As reported previously also (3,4), the VPEL in darkness was considerably lower at 1.5 g than at 1.0 g: however, although the y-intercept of the VPEL-vs-pitch function in the presence of the 2-line visual field (visual field erect) was also lower at 1.5 g than at 1.0 g as it was in darkness, the G-related difference was significantly attenuated by the presence of the visual field. The quantitative characteristics of the results are consistent with a model in which VPEL is treated as a consequence of an algebraic weighted average or a vector sum of visual and nonvisual influences although the two combining rules lead to fits that are equally good.
The directions of nystagmus and apparent self-motion evoked by caloric tests and angular accelerations
Authors: Kolev Ognyan I. 
Published: September 2021

Purpose: To further investigate the direction of (I) nystagmus and (II) self-motion perception induced by two stimuli: (a) caloric vestibular stimulations and (b) a sudden halt during vertical axis rotation. Subjects and methods: Twelve normal humans received caloric stimulation at 44°C, 30°C, and 20°C while in a supine position with the head inclined 30° upwards. In a second test they were rotated around the vertical axis with the head randomly placed in two positions: tilted 30° forward or tilted 60° backward, at a constant velocity of 90°/sec for 2 minutes and then suddenly stopped. After both tests they were asked to describe their sensations of self-motion. Eye movements were recorded with an infrared video-technique. Results: Caloric stimulation evoked only horizontal nystagmus in all subjects and induced a non-uniform complex perception of angular in frontal and transverse planes (the former dominated) and linear movements along the antero-posterior axis (sinking dominated) of the subject's coordinates. The self-motion was felt with the whole body or with a part of the body. Generally the perception evoked by cold (30°C) and warm (44°C) calorics was similar, although there were some differences. The stronger stimulus (20°C) evoked not only quantitative but also qualitative differences in perception. The abrupt halt of rotation induced self-motion perception and nystagmus only in the plane of rotation. The self-motion was felt with the whole body. Conclusion: There was no difference in the nystagmus evoked by caloric stimulation and a sudden halt of vertical axis rotation (in head positions to stimulate the horizontal canals); however, the two stimuli evoked different perceptions of self-motion. Calorics provoked the sensation of self-rotation in the frontal plane and linear motion, which did not correspond to the direction of nystagmus, as well as arcing and a reset phenomenon during angular and linear self-motion, caloric-induced self-motion can be felt predominantly or only with a part of the body, depending on the self-motion intensity. The findings indicate that, unlike the self-motion induced by sudden halt of vertical axis rotation, several mechanisms take part in generating caloric-induced self-motion.
Head sway response to optic flow: Effect of age is more important than the presence of unilateral vestibular hypofunction
Authors: Sparto Patrick J. , Furman Joseph M. , Redfern Mark S. 
Published: September 2021

Background: The purpose of this study was to examine how older adults with vestibular impairment use sensory feedback for postural control. Methods: Nine older adult subjects with unilateral vestibular hypofunction (UVH, mean age 69 y) and 14 older (mean age 70 y) and 8 young adult controls (CON, mean age 28 y) viewed full-field optic flow scenes while standing on a fixed or sway-referenced support surface. The subjects with UVH had 100% caloric asymmetry. Optic flow consisted of sinusoidal anterior-posterior movement of the visual surround at three frequencies and three amplitudes of stimulation. The anterior-posterior head sway was measured. The number of head sway responses that were coupled to the optic flow and magnitude of head sway during optic flow relative to during quiet stance on fixed floor was quantified. Results: The number of trials in which the head sway response was significantly coupled to the optic flow was significantly greater in the Older UVH and Older CON subjects compared with the Young CON subjects. Furthermore, the magnitude of head sway was two to three times greater in Older UVH and CON compared with Young CON subjects. There was no difference in coupling or magnitude of head sway between Older UVH and Older CON subjects. The amplitude of sway was also dependent on the amount of surface support, stimulus frequency, and stimulus amplitude. Conclusions: Older adults with unilateral vestibular hypofunction who are able to effectively compensate show no difference in postural responses elicited by optic flow compared with age-matched controls.
Analysis of the pedestrian traffic in transport nodes in Radom
Authors: Dębowska-Mróz Marzenna , Ferensztajn-Galardos Ewa , Krajewska Renata , Rogowski Andrzej 
Published: September 2021

The efficient functioning of the transport system in each area requires that account be taken of the fact that each journey consists of a chain of elementary movements on foot or by means of trans­port. The construction of an effective public transport system is one of the methods to reduce traffic congestion, especially in city centres. The inter-change synchronization is the way to increase the efficiency of public transport.
The purpose of the paper is to present the results of research on the intensity of pedestrian traffic at interchanges as a function of time in the city of Radom. Pedestrian movements play an important role not only in the vicinity of transport nodes. Their production and quality also determine the assessment of these movements as one of the stages of production of combined movements. The tendency to pedestrian travel (or lack of it) also affects public and individual transport journeys. Based on the survey conducted in households, the structure of movement (size and motivations) of the inhabitants of Radom is given.
Learning Nursing Ethics - Experience of Students of Dhaka Nursing College, Bangladesh
Authors: ASM Nurunnabi 
Published: September 2021

Nursing ethics is taught in the subject 'Fundamentals of Nursing' in BSc Nursing curriculum in Bangladesh. The present study aims to examine nurse students' opinion regarding their learning nursing ethics. A total of 183 nursing students of Dhaka Nursing College, Bangladesh, from 1st year and 2nd year of BSc in Nursing course participated in this study, which was done between July and September, 2011. A semi-structured questionnaire was given to them. Besides mentioning their age, sex, socio-economic status, the students were asked to provide information about their acquisition and application of knowledge on codes of ethics and an evaluation on faculties (23 items). Most of the students were from low socio-economic condition (n=157, 85.79%). Nursing students perceived that their educators' teaching of the statements of the codes was fairly extensive (ranged from 3.32±0.365 to 3.59±0.923). The highest scores dealt with the nurse-patient relationship, and the mission of nurses. Single items with highest scores highlighted confidentiality, alleviation of suffering, impartiality, support to patients and patients' family members, personal responsibility of her/his work and the quality of care as well as respect to human dignity and autonomy. The least taught statements concerned nurses and society and nursing as a profession. Single items with lowest scores dealt with nurses' professional competence, nurses' participation in discussion and decision-making. Students regarded their own knowledge of the code of ethics (3.45±0.585) and their skills to apply in practice (3.51±0.573) as average. Two-thirds of students (n=122; 66.67%) assessed their educators' knowledge as fully or almost adequate to teach, 15.85% (n=29) of the students assessed the knowledge as less adequate, and 17.48% (n=32) could not assess it. Studying nursing students' opinions on learning nursing ethics would be a useful guide for the formation of their professional role as well as their education and training.
CBMJ 2019 January: vol. 08 no. 01 P: 30-34
Does Malachi 1:2-3 Teach Double Predestination?
Authors: Chia Philip Suciadi , Juanda Juanda 
Published: September 2021

The term ‘double predestination’ simply means that, just as God predestines some, but not all, to eternal salvation, so he predestines others to eternal punishment; this second part of ‘double predestination’, God's appointment of all but the elect unto eternal destruction, is sometimes called ‘reprobation’; and those who are not the elect are thus called the ‘reprobate’.The object of Malachi was in reminding the Jews that they were loved and chosen by God; it was, that he might the more amplify their ingratitude for having rendered such an unworthy reward for so great a favor of God: as he had preferred them to all other nations, he had justly bound them to perpetual obedience
With the inductive method, we will present a more objective truth of Scripture. We will not only explain the truth of the Bible would conclude (correct interpretation), but also accompanied by the evidence and arguments of the conclusions.
In conclusion, the meaning of hate in this context is God hated Esau, the absence of affection, because he is a sinful people therefore Yahweh opposed and kept distant from him (have no relationship). Based on this meaning, we can summarize that this verse (Mal. 1:3) doesn’t teach about reprobation that God has predestined Esau to go to eternal destruction because Yahweh hated him beforehand but Lord indeed hated Edomites because they are sinful people.
Analytical Evaluation of Dried Blood Spot and Rapid Diagnostic Test as a New Strategy for Serological Community Screening for Chronic Chagas Disease
Authors: Silgado Aroa , Gual-Gonzalez Lídia , Sánchez-Montalvá Adrián , Oliveira-Souto Inés , Goterris Lidia , Serre-Delcor Nuria , Esperalba Juliana , Gomez-i-Prat Jordi , Fernández-Naval Candela , Molina Israel , Pumarola Tomas , Sulleiro Elena 
Published: September 2021

BackgroundChagas disease is a public health problem not only in Latin America, but also in other regions, including Spain, due to migration movements. Conventional serological diagnosis requires an invasive sample (plasma or serum) and a well-equipped laboratory. To circumvent those limitations, blood samples dried on filter paper (DBS) or Rapid Diagnostic Test (RDT) could be a practical alternative to reference protocol for serological screening in epidemiological studies. We evaluated the usefulness of dried blood sampling and a rapid diagnostic test (Trypanosoma Detect™) for the detection of antibodies against T. cruzi for their use in community-based screening.Methodology/Principal FindingsA total of 162 stored paired whole-blood and serum samples from Latin American migrants and 25 negative-control blood samples were included. Diagnosis of chronic Chagas disease was performed in serum according to WHO algorithms. Blood samples were retrospectively collected as dried spots and then analyzed using two different serological techniques, enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (E-CLIA). Whole-blood samples were also used to evaluate a rapid diagnostic test based on immunochromatography. A better correlation with conventional serum was observed in dried blood elutes using E-CLIA than ELISA (97% vs. 77% sensitivity, respectively). Both assays reported 100% specificity. The median cut-off index values of E-CLIA for dried blood were significantly lower than those for serum (138.1 vs. 243.3, P&lt;0.05). The Trypanosoma Detect™ test presented a sensitivity and specificity of 89.6% and 100%, respectively.ConclusionsThe detection of antibodies against T. cruzi in dried blood samples shows a higher sensitivity when using E-CLIA compared with ELISA. Trypanosoma Detect™ is easier to use but has a lower sensitivity. Hence, we propose a sequential strategy based on performing the rapid test first, and a negative result will be confirmed by DBS-ECLIA for use in community Chagas disease screening programs.
Earthquake Dynamic Failure Mechanism of Dangerous Rock Based on Dynamics and PFC3D
Authors: Tian Yun , Wu Yong , Li Hongtao , Ren Bangzheng , Wang Hao 
Published: September 2021

The dynamic failure mechanism of horizontally layered dangerous rock during earthquakes is complex and only few studies have addressed the combination of particle flow code (PFC) meso-level failure mechanism and mechanical analysis. Based on fracture mechanics and material mechanics we establish a calculation method for the interlayer load and stability coefficient of horizontal layered dangerous rock during strong earthquakes. The method was applied for calculating the stability of a horizontally layered dangerous slope along a highway in the Sichuan Province (China) during earthquakes as a case study. Using a 3D particle flow simulation technology, a PFC3D model of horizontal layered dangerous rock was established. Its dynamic stability, failure mode and Hilbert-Huang 3D time-frequency characteristics are analyzed, and the results of the simulation are largely consistent with the time of the dangerous rock failure as estimated by our new calculation method. Our study documents that as the seismic acceleration gradually increases, the stability coefficient of the rock block fluctuates more violently and the stability coefficient gradually decreases. The stability coefficient of the rock block decreases fastest between 5 and 6 s and the reduction in the stability coefficient is between 0.12 and 0.25. Before the seismic acceleration reaches the maximum, the dangerous rock blocks on the two main controlling structures collapse and get destroyed. 25 s after the earthquake, the failure mode of the dangerous rock is collapse-slip-rotation. We show that earthquakes with frequencies of 0–10 and 250 Hz have the strongest destructive effect on the stability of the horizontally layered dangerous rocks.
Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus
Authors: Li Mengni , Fan Rongping , Peng Xuemin , Huang Jiaojiao , Zou Huajie , Yu Xuefeng , Yang Yan , Shi Xiaoli , Ma DeLin 
Published: September 2021

BackgroundPrevious studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration in ANGPTL-8 and resistin level can be a predictive maker for increased diabetic nephropathy risk remains unclear.AimTo Investigate the possible association of ANGPTL-8 and resistin with DN, and whether this association is affected by NAFLD status.MethodsA total of 278 T2DM patients were enrolled. Serum levels of ANGPTL8, resistin, BMI, blood pressure, duration of diabetes, glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), hypersensitive C-reactive protein (hs-CRP), lipid profile, liver, and kidney function tests were assessed. The relationship between DN with ANGPTL8 and resistin was analyzed in the unadjusted and multiple-adjusted regression models.ResultsSerum levels of ANGPTL8 and resistin were significantly higher in DN compared with T2DM subjects without DN (respectively; P &lt;0.001), especially in non-NAFLD populations. ANGPTL8 and resistin showed positive correlation with hs-CRP (respectively; P&lt;0.01), and negative correlation with estimated GFR (eGFR) (respectively; P=&lt;0.001) but no significant correlation to HOMA-IR(respectively; P&gt;0.05). Analysis showed ANGPTL8 levels were positively associated with resistin but only in T2DM patients with DN(r=0.1867; P&lt;0.05), and this significant correlation disappeared in T2DM patients without DN. After adjusting for confounding factors, both ANGPTL8(OR=2.095, 95%CI 1.253-3.502 P=0.005) and resistin (OR=2.499, 95%CI 1.484-4.208 P=0.001) were risk factors for DN. Data in non-NAFLD population increased the relationship between ANGPTL8 (OR=2.713, 95% CI 1.494-4.926 P=0.001), resistin (OR=4.248, 95% CI 2.260-7.987 P&lt;0.001)and DN. The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8 and resistin was 0.703, and the specificity was 70.4%. These data were also increased in non-NAFLD population, as the AUC (95%CI) was 0.756, and the specificity was 91.2%.ConclusionThis study highlights a close association between ANGPTL8, resistin and DN, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors of DN.
Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors
Authors: Kennedy Susan A. , Annett Stephanie L. , Dunne Margaret R. , Boland Fiona , O’Neill Linda M. , Guinan Emer M. , Doyle Suzanne L. , Foley Emma K. , Elliott Jessie A. , Murphy Conor F. , Bennett Annemarie E. , Carey Michelle , Hillary Daniel , Robson Tracy , Reynolds John V. , Hussey Juliette , O’Sullivan Jacintha 
Published: September 2021

BackgroundThe Rehabilitation Strategies Following Esophagogastric cancer (ReStOre) randomized control trial demonstrated a significant improvement in cardiorespiratory fitness of esophagogastric cancer survivors. This follow-up, exploratory study analyzed the biological effect of exercise intervention on levels of 55 serum proteins, encompassing mediators of angiogenesis, inflammation, and vascular injury, from participants on the ReStOre trial.MethodsPatients &gt;6 months disease free from esophagogastric cancer were randomized to usual care or the 12-week ReStOre program (exercise training, dietary counselling, and multidisciplinary education). Serum was collected at baseline (T0), post-intervention (T1), and at 3-month follow up (T2). Serum biomarkers were quantified by enzyme-linked immunosorbent assay (ELISA).ResultsThirty-seven patients participated in this study; 17 in the control arm and 20 in the intervention arm. Exercise intervention resulted in significant alterations in the level of expression of serum IP-10 (mean difference (MD): 38.02 (95% CI: 0.69 to 75.35)), IL-27 (MD: 249.48 (95% CI: 22.43 to 476.53)), and the vascular injury biomarkers, ICAM-1 (MD: 1.05 (95% CI: 1.07 to 1.66)), and VCAM-1 (MD: 1.51 (95% CI: 1.04 to 2.14)) at T1. A significant increase in eotaxin-3 (MD: 2.59 (95% CI: 0.23 to 4.96)), IL-15 (MD: 0.27 (95% CI: 0 to 0.54)) and decrease in bFGF (MD: 1.62 (95% CI: -2.99 to 0.26)) expression was observed between control and intervention cohorts at T2 (p&lt;0.05).ConclusionsExercise intervention significantly altered the expression of a number of serum biomarkers in disease-free patients who had prior treatment for esophagogastric cancer.ImpactExercise rehabilitation causes a significant biological effect on serum biomarkers in esophagogastric cancer survivors.Clinical Trial RegistrationClinicalTrials.gov (NCT03314311).
Calmodulin 2 Facilitates Angiogenesis and Metastasis of Gastric Cancer via STAT3/HIF-1A/VEGF-A Mediated Macrophage Polarization
Authors: Mu Ganggang , Zhu Yijie , Dong Zehua , Shi Lang , Deng Yunchao , Li Hongyan 
Published: September 2021

BackgroundTumor-associated macrophages (TAMs) are indispensable to mediating the connections between cells in the tumor microenvironment. In this study, we intended to research the function and mechanism of Calmodulin2 (CALM2) in gastric cancer (GC)-TAM microenvironment.Materials and methodsCALM2 expression in GC tissues and GC cells was determined through quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC). The correlation between CALM2 level and the survival rate of GC patients was assessed. The CALM2 overexpression or knockdown model was constructed to evaluate its role in GC cell proliferation, migration, and invasion. THP1 cells or HUVECs were co-cultured with the conditioned medium of GC cells. Tubule formation experiment was done to examine the angiogenesis of endothelial cells. The proliferation, migration, and polarization of THP1 cells were measured. A xenograft model was set up in BALB/c male nude mice to study CALM2x’s effects on tumor growth and lung metastasis in vivo. Western Blot (WB) checked the profile of JAK2/STAT3/HIF-1/VEGFA in GC tissues and cells.ResultsIn GC tissues and cell lines, CALM2 expression was elevated and positively relevant to the poor prognosis of GC patients. In in-vitro experiments, CALM2 overexpression or knockdown could facilitate or curb the proliferation, migration, invasion, and angiogenesis of HUVECs and M2 polarization of THP1 cells. In in-vivo experiments, CALM2 boosted tumor growth and lung metastasis. Mechanically, CALM2 could arouse the JAK2/STAT3/HIF-1/VEGFA signaling. It was also discovered that JAK2 and HIF-1A inhibition could attenuate the promoting effects of CALM2 on GC, HUVECs cells, and macrophages.ConclusionCALM2 modulates the JAK2/STAT3/HIF-1/VEGFA axis and bolsters macrophage polarization, thus facilitating GC metastasis and angiogenesis.