bluuebunny/crossref_metadata_2025_split huggingface dataset:
CoNi alloy nanoparticles for cancer theranostics: synthesis, physical characterization, in vitro and in vivo studies
Authors: Sargazi Saman , Hajinezhad Mohammad Reza , Rahdar Abbas , Mukhtar Mahwash , Karamzadeh-Jahromi Milad , Almasi-Kashi Mohammad , Alikhanzadeh-Arani Sima , Barani Mahmood , Baino Francesco 
Published: September 2021

AbstractNanomaterials are attracting increasing interest in many biomedical fields, including the fight against cancer. In this context, we successfully synthesized CoNi alloy nanoparticles (NPs) by a simple polyol process. The magnetic characteristics of the products were measured by vibration sample magnometry, which revealed that the samples have soft ferromagnetic behavior. The microstructure and morphology were inspected by X-ray diffraction and scanning electron microscopy, respectively. Human cancer cells derived from the breast (MCF7) and oral cavity (C152) and normal cells derived from human umbilical vein endothelial cells (HUVECs) were treated with increasing concentrations of CoNi NPs, and their cytotoxic effect was measured via MTT and lactate dehydrogenase (LDH) leakage assays. We found that treatments by using 12.5 to 400 µg/mL of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs were associated with significant concentration-dependent toxicity toward such cell lines and profoundly enhanced LDH leakage following 48 h of exposure (P < 0.05 compared with untreated cells). Besides, a NP dose of 6.25 µg/mL did not affect the survival of HUVECs while leading to marked cell death in MCF7 and C152 cells. In vivo experiments in rats were done to investigate the biochemical and histopathological changes over three weeks, following intraperitoneal administration of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs (100 mg/kg). As compared with the controls, the exposure to NPs caused significant elevations in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, serum creatinine, serum catalase activity, serum superoxide dismutase, and liver malondialdehyde levels. Also, rats treated with Co0.6Ni0.4 NPs showed more severe histopathological changes of the liver and kidney. Our findings represent an essential step toward developing theranostic nanoplatforms for selective cancer treatment.
A Note on Stability for Maximal F-Free Graphs
Authors: Gerbner Dániel 
Published: September 2021

AbstractPopielarz, Sahasrabuddhe and Snyder in 2018 proved that maximal$$K_{r+1}$$Kr+1-free graphs with$$(1-\frac{1}{r})\frac{n^2}{2}-o(n^{\frac{r+1}{r}})$$(1-1r)n22-o(nr+1r)edges contain a completer-partite subgraph on$$n-o(n)$$n-o(n)vertices. This was very recently extended to odd cycles in place of$$K_3$$K3by Wang, Wang, Yang and Yuan. We further extend it to some other 3-chromatic graphs, and obtain some other stability results along the way.
The spectrum and differential diagnosis of acquired ocular motor nerve palsies: a clinical study of 502 patients
Authors: Hörner Rebecca , Kassubek Jan , Dreyhaupt Jens , Ludolph Albert C. 
Published: September 2021

Abstract
Background
Ocular motor nerve palsies (OMNP) frequently cause patients to present in an emergency room. In the following study, we report the differential diagnosis of OMNP by use of magnetic resonance imaging (MRI) and CSF examination as a standard.

Method
We performed a data analysis of N = 502 patients who presented with oculomotor, trochlear, and/or abducens nerve palsy in the emergency room of the Department of Neurology, University of Ulm, between January 2006 and December 2019. We report clinical and MRI scan findings in all patients; furthermore, the CSF of 398 patients has been analysed.

Results
Abducens nerve palsies were most common (45%), followed by palsies of the oculomotor (31%) (CNP III) and trochlear nerve (15%). Multiple OMNPs were seen in 9% of our cohort. The most common causes included inflammations (32.7%), space-occupying lesions, such as aneurysms or neoplasms (17.3%), diabetes mellitus (13.3%), and brainstem infarctions (11%). Still 23.4% of the patients could not be assigned to any specific cause after differential diagnostic procedures and were described as idiopathic. One of three patients with an inflammation and 39% of the patients with space-occupying lesions showed additional cranial nerve deficits.

Conclusion
Inflammation and space-occupying processes were the most frequent causes of OMNP, although brainstem infarctions also play a significant role, in particular in CNP III. The presence of additional CNPs increases the probability of an inflammatory or space-occupying cause.
Preoperative splenic artery embolism followed by splenectomy is safe and effective in patients with sinistral portal hypertension
Authors: Wang Zihe , Li Mao , Huang Xing , Xiong Junjie , Tian Bole 
Published: September 2021

Abstract
Background

Although preoperative splenic artery embolism (SAE) has been widely used for splenomegaly, the efficiency and safety of preoperative SAE in patients with sinistral portal hypertension (SPH) is unknown.

Methods
We designed a retrospective cohort of SPH patients who received preoperative SAE in our hospital (February 2018 to September 2020) and compared to those who received splenectomy only, in terms of intraoperative and postoperative outcomes.

Results
In all, 59 patients (18 patients received preoperative SAE) were analyzed. The median age was 44.7 years. Preoperative SAE reduced the intraoperative blood loss (637.0 vs. 420.3 ml, P = 0.041) and operation time (174.0 vs. 141.5 min, P = 0.012). The incidence of complications including postoperative pancreatic fistula (POPF), bleeding, and thromboembolism was comparable. Multivariate analysis showed that SAE was a protective factor for intraoperative blood loss and operation time, while prior pancreatic pseudocyst/abscess was a risk factor.

Conclusions
Preoperative SAE could reduce intraoperative blood loss and operation time in SPH patients without increasing the incidence of complications compared to splenectomy only.
EDP-convergence for a linear reaction-diffusion system with fast reversible reaction
Authors: Stephan Artur 
Published: September 2021

AbstractWe perform a fast-reaction limit for a linear reaction-diffusion system consisting of two diffusion equations coupled by a linear reaction. We understand the linear reaction-diffusion system as a gradient flow of the free energy in the space of probability measures equipped with a geometric structure, which contains the Wasserstein metric for the diffusion part and cosh-type functions for the reaction part. The fast-reaction limit is done on the level of the gradient structure by proving EDP-convergence with tilting. The limit gradient system induces a diffusion system with Lagrange multipliers on the linear slow-manifold. Moreover, the limit gradient system can be equivalently described by a coarse-grained gradient system, which induces a diffusion equation with a mixed diffusion constant for the coarse-grained slow variable.
Optimal transport of vector measures
Authors: Ciosmak Krzysztof J. 
Published: September 2021

AbstractWe develop and study a theory of optimal transport for vector measures. We resolve in the negative a conjecture of Klartag, that given a vector measure on Euclidean space with total mass zero, the mass of any transport set is again zero. We provide a counterexample to the conjecture. We generalise the Kantorovich–Rubinstein duality to the vector measures setting. Employing the generalisation, we answer the conjecture in the affirmative provided there exists an optimal transport with absolutely continuous marginals of its total variation.
Dynamical collapse of cylindrical symmetric dipolar Bose–Einstein condensates
Authors: Bellazzini Jacopo , Forcella Luigi 
Published: September 2021

AbstractWe study the formation of singularities for cylindrical symmetric solutions to the Gross–Pitaevskii equation describing a dipolar Bose–Einstein condensate. We prove that solutions arising from initial data with energy below the energy of the Ground State and that do not scatter collapse in finite time. The main tools to prove our result are the variational characterization of the Ground State energy, suitable localized virial identities for cylindrical symmetric functions, and general integral and pointwise estimates for operators involving powers of the Riesz transform.
Potential traumatic events and symptoms of post-traumatic stress in unaccompanied refugee minors—a comparison with youth in foster care
Authors: Kvestad Ingrid , Bøe Tormod , Sayyad Nawar , Skogen Jens Christoffer , Randal Sølve , Lehmann Stine 
Published: September 2021

AbstractBuilding knowledge on how child welfare services (CWS) should tailor services for unaccompanied refugee minors (URMs) is important. URMs and youth in foster care are high-risk groups taken care of by the CWS in Norway. Little is known on whether knowledge gained from youth in foster care can inform services for URMs, and if these groups are comparable in terms of experiences of potential traumatic events (PTEs) and post-traumatic stress disorder (PTSD) symptom load. Eighty-one URMs reported PTEs and PTSD-symptoms using an adapted version of the Child and Adolescent Trauma Screen (CATS). Responses were described and compared with a sample of 303 youth in foster care in linear regression models. We present relative risks (RR) and standardized mean differences (SMD) for the PTEs and the PTSD subscale and total score between the groups in forest plots. URMs had experienced a mean (standard deviation) of 6.4 (3.4) PTEs and 43.9% reported to have PTSD-symptoms at or above the clinical cut off. Compared to the foster youth, URMs reported more exposures of interpersonal violence outside of the family (RRs ranging from 66.4 [95%CI 18.1; 243.5) to 1.3 (1.0, 1.5)], and more PTSD-symptoms in the re-experiencing subscale [SMD = 0.3 (95% CI 0.1, 0.6)]. The frequency and types of PTEs and the PTSD-symptom load and profile among URMs and youth in foster care differed. Findings underscore the importance of qualified and targeted care for URMs, and that this care should differ to that of other high-risk groups in the CWS.
Influence of shape-memory stent grafts on local aortic compliance
Authors: Concannon J. , Moerman KM , Hynes N. , Sultan S. , McGarry JP 
Published: September 2021

AbstractThe effect of repair techniques on the biomechanics of the aorta is poorly understood, resulting in significant levels of postoperative complications for patients worldwide. This study presents a computational analysis of the influence of Nitinol-based devices on the biomechanical performance of a healthy patient-specific human aorta. Simulations reveal that Nitinol stent-grafts stretch the artery wall so that collagen is stretched to a straightened high-stiffness configuration. The high-compliance regime (HCR) associated with low diastolic lumen pressure is eliminated, and the artery operates in a low-compliance regime (LCR) throughout the entire cardiac cycle. The slope of the lumen pressure–area curve for the LCR post-implantation is almost identical to that of the native vessel during systole. This negligible change from the native LCR slope occurs because the stent-graft increases its diameter from the crimped configuration during deployment so that it reaches a low-stiffness unloading plateau. The effective radial stiffness of the implant along this unloading plateau is negligible compared to the stiffness of the artery wall. Provided the Nitinol device unloads sufficiently during deployment to the unloading plateau, the degree of oversizing has a negligible effect on the pressure–area response of the vessel, as each device exerts approximately the same radial force, the slope of which is negligible compared to the LCR slope of the native artery. We show that 10% oversizing based on the observed diastolic diameter in the mid descending thoracic aorta results in a complete loss of contact between the device and the wall during systole, which could lead to an endoleak and stent migration. 20% oversizing reaches the Dacron enforced area limit (DEAL) during the pulse pressure and results in an effective zero-compliance in the later portion of systole.
Active Lives South Australia health economic analysis: an evidence base for the potential of health promotion strategies supporting physical activity guidelines to reduce public health costs while improving wellbeing
Authors: Eckermann Simon , Willan Andrew R. 
Published: September 2021

Abstract
Aim
The COVID-19 pandemic has threatened individual and population wellbeing and strategies to jointly address these challenges within budget constraints are required. The aim of our research is to analyse evidence from the Active Lives South Australia study to consider the potential of physical activity (PA) health promotion strategies to be health-system cost saving while addressing wellbeing challenges.

Methods
The Active Lives South Australia study compares adult populations who meet and do not meet physical activity (PA) guidelines (150+ minutes of weekly physical activity) with respect to their subjective wellbeing and health care utilisation.

Subject and results
Adults who met PA guidelines had better wellbeing across all aspects with and without adjustment for age, sex and income covariates. Analysis showed significant associations between meeting guidelines and lower probabilities of visiting and utilisation of GPs, specialist doctors, other health professionals, hospital inpatient admissions, outpatient clinic and emergency department visits, and an overall A$1760 lower cost per person annually. Controlling for age, sex and income, health expenditure for adults who met PA guidelines was significantly lower by A$1393 per person annually. That translated to A$804 million potential annual SA health system cost saving by shifting all adults to meeting PA guidelines.

Conclusion
There is significant potential for effective health promotion strategies to be net cost saving while addressing wellbeing challenges of COVID-19 recovery where they can shift target populations from not meeting to meeting PA guidelines.
Untargeted metabolomics in primary murine bone marrow stromal cells reveals distinct profile throughout osteoblast differentiation
Authors: Misra Biswapriya B. , Jayapalan Shobana , Richards Alison K. , Helderman Ron C. M. , Rendina-Ruedy Elizabeth 
Published: September 2021

Abstract
Introduction
Skeletal homeostasis is an exquisitely regulated process most directly influenced by bone resorbing osteoclasts, bone forming osteoblasts, and the mechano-sensing osteocytes. These cells work together to constantly remodel bone as a mechanism to prevent from skeletal fragility. As such, when an individual experiences a disconnect in these tightly coupled processes, fracture incidence increases, such as during ageing, gonadal hormone deficiency, weightlessness, and diabetes. While therapeutic options have significantly aided in the treatment of low bone mineral density (BMD) or osteoporosis, limited options remain for anabolic or bone forming agents. Therefore, it is of interest to continue to understand how osteoblasts regulate their metabolism to support the energy expensive process of bone formation.

Objective
The current project sought to rigorously characterize the distinct metabolic processes and intracellular metabolite profiles in stromal cells throughout osteoblast differentiation using untargeted metabolomics.

Methods
Primary, murine bone marrow stromal cells (BMSCs) were characterized throughout osteoblast differentiation using standard staining protocols, Seahorse XFe metabolic flux analyses, and untargeted metabolomics.

Results
We demonstrate here that the metabolic footprint of stromal cells undergoing osteoblast differentiation are distinct, and while oxidative phosphorylation drives adenosine triphosphate (ATP) generation early in the differentiation process, mature osteoblasts depend on glycolysis. Importantly, the intracellular metabolite profile supports these findings while also suggesting additional pathways critical for proper osteoblast function.

Conclusion
These data are the first of their kind to characterize these metabolites in conjunction with the bioenergetic profile in primary, murine stromal cells throughout osteoblast differentiation and provide provocative targets for future investigation.
Purification of recovered phosphoric acid by extracting aluminium with di-2-ethylhexyl phosphoric acid
Authors: Reuna Sini , Väisänen Ari 
Published: September 2021

AbstractThe extraction of aluminium from dilute phosphoric acid with di-2-ethylhexyl phosphoric acid (DEHPA) was optimized using response surface methodology. The optimization was based on the experimental three-level central composite face-centred design (CCF) and was conducted on real-life samples. The three variables included were pH, extractant concentration and aqueous to organic phase ratio (AO). Under the optimized conditions (pH 2.5, 0.6 M DEHPA and AO ratio 1:2), extraction efficiency of 99% for aluminium in four extraction stages is achieved. The purified phosphoric acid solution can then be utilized by the fertilizing industry. Stripping tests for organic phase loaded with aluminium were conducted with sulphuric acid. Extremely high stripping efficiency was obtained with 0.9 M sulphuric acid resulting in the recovery rate of 88% in one stage. After stripping, the aluminium sulphate solution can be reused as a precipitation agent for phosphorus in the wastewater treatment process.
Core curriculum in pathology for future Irish medical students
Authors: Humphreys Hilary , Stevens Niall , Burke Louise , Sheehan Mariam , Glavey Siobhán , Keogan Mary , Rasheed Erum ,   the Faculty of Pathology, the Royal College of Physicians in Ireland
Published: September 2021

AbstractPathology is important in training to become a medical doctor but as curricula become more integrated, there is a risk that key aspects of pathology may be excluded. Following a survey of the current delivery of teaching in Ireland under the auspices of the Faculty of Pathology at the Royal College of Physicians of Ireland, suggested components of a core curriculum in pathology have been developed to be delivered at some stage during the medical course. These have been based on key principles and themes required by the Medical Council in Ireland. Professionalism is one of the core principles emphasised by the Medical Council. It includes the role of the pathologist in patient care and other professional values such as patient-centred care, clinical competencies and skills, e.g. explaining results, and knowledge under the various sub-disciplines, i.e. histopathology (including neuropathology), clinical microbiology, haematology, chemical pathology and immunology. In each of these, we suggest key aspects and activities that the medical graduate should be comfortable in carrying out. The methods of delivery of teaching and assessment across pathology disciplines have evolved and adapted to recent circumstances. Lessons have been learned and insights gained during the COVID-19 pandemic as educators have risen to the challenge of continuing to educate medical students. Integrated and multi-disciplinary teaching is recommended to reflect best the professional environment of the medical graduate who works as an integral part of a multi-disciplinary team, with the minimum dependence on the traditional lecture, where at all possible. Finally, options on assessment are discussed, e.g. multiple-choice questions, including their respective advantages and disadvantages.
Avoiding cross-sex friendships: The separability of people with and without cross-sex friends
Authors: Altmann Tobias 
Published: September 2021

AbstractPrior studies on individual differences in the preference for cross-sex friendships found that this preference was not normally distributed but was instead bimodal. In one group of people, the preferences for higher or lower proportions of cross-sex friendships appear to be normally distributed, whereas in a second and unexpectedly large group of people, the preference for cross-sex friends is exactly zero. If the people in the second group with no cross-sex friends at all actively avoid forming cross-sex friendships, then these individuals may be expected to differ systematically and meaningfully from individuals who report having at least one cross-sex friend. The present study tests this hypothesis. The Big Five, homophobia, physical attraction to the opposite sex, and demographic variables from a data set of 491 adult participants were used as potential predictors of group membership. Results showed that most predictors except the Big Five contributed to supporting the separability of the two groups. Findings are discussed with regard to the differentiation between close and general friends and the potential influence of cultural factors.
The behavior and functions of embryonic microglia
Authors: Hattori Yuki 
Published: September 2021

AbstractMicroglia are the resident immune cells of the central nervous system. Microglial progenitors are generated in the yolk sac during the early embryonic stage. Once microglia enter the brain primordium, these cells colonize the structure through migration and proliferation during brain development. Microglia account for a minor population among the total cells that constitute the developing cortex, but they can associate with many surrounding neural lineage cells by extending their filopodia and through their broad migration capacity. Of note, microglia change their distribution in a stage-dependent manner in the developing brain: microglia are homogenously distributed in the pallium in the early and late embryonic stages, whereas these cells are transiently absent from the cortical plate (CP) from embryonic day (E) 15 to E16 and colonize the ventricular zone (VZ), subventricular zone (SVZ), and intermediate zone (IZ). Previous studies have reported that microglia positioned in the VZ/SVZ/IZ play multiple roles in neural lineage cells, such as regulating neurogenesis, cell survival and neuronal circuit formation. In addition to microglial functions in the zones in which microglia are replenished, these cells indirectly contribute to the proper maturation of post-migratory neurons by exiting the CP during the mid-embryonic stage. Overall, microglial time-dependent distributional changes are necessary to provide particular functions that are required in specific regions. This review summarizes recent advances in the understanding of microglial colonization and multifaceted functions in the developing brain, especially focusing on the embryonic stage, and discuss the molecular mechanisms underlying microglial behaviors.
Hybrid feature selection approach to identify optimal features of profile metadata to detect social bots in Twitter
Authors: Alothali Eiman , Hayawi Kadhim , Alashwal Hany 
Published: September 2021

AbstractThe last few years have revealed that social bots in social networks have become more sophisticated in design as they adapt their features to avoid detection systems. The deceptive nature of bots to mimic human users is due to the advancement of artificial intelligence and chatbots, where these bots learn and adjust very quickly. Therefore, finding the optimal features needed to detect them is an area for further investigation. In this paper, we propose a hybrid feature selection (FS) method to evaluate profile metadata features to find these optimal features, which are evaluated using random forest, naïve Bayes, support vector machines, and neural networks. We found that the cross-validation attribute evaluation performance was the best when compared to other FS methods. Our results show that the random forest classifier with six optimal features achieved the best score of 94.3% for the area under the curve. The results maintained overall 89% accuracy, 83.8% precision, and 83.3% recall for the bot class. We found that using four features:favorites_count,verified,statuses_count, andaverage_tweets_per_day,achieves good performance metrics for bot detection (84.1% precision, 81.2% recall).