bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiarrhythmic drug loading at home using remote monitoring: a virtual feasibility study during COVID-19 social distancing
Authors: Shah Rajan L , Kapoor Ridhima , Bonnett Colleen , Ottoboni Linda K , Tacklind Christine , Tsiperfal Angela , Perez Marco V 
Published: March 2021

Abstract
The epidemiological necessity for distancing during the COVID-19 pandemic has resulted in postponement of non-emergent hospitalizations and increase use of telemedicine. The feasibility of virtual antiarrhythmic drug (AAD) loading specifically with digital QTc electrocardiographic monitoring (EM) in conjunction with telemedicine video visits is not well established. We tested the hypothesis that existing digital health technologies and virtual communication platforms could provide EM and support medically guided AAD loading for patients with symptomatic tachyarrhythmia in the ambulatory setting, while reducing physical contact between patient and healthcare system. A prospective pilot, case series was approved by the institutional ethics committee, entailing three subjects with symptomatic arrhythmia during the COVID-19 pandemic who were enrolled for virtual AAD loading at home. Clinicians met with participants twice daily via video visits conducted after QTc analysis (Kardia 6L mobile sensor) and telemetry review (Mobile Cardiac Outpatient Telemetry of silent arrhythmias). Participants received direct instruction to either terminate the study or proceed with the next single dose of AAD. All participants completed contactless loading of five AAD doses, without untoward event. Scheduled video visits allowed dialogue and participant counselling where decision-making was guided by remote review of EM. Participant adherence with transmissions and scheduled visits was 98.3%; a single electrocardiogram was delayed beyond the 2 hours of post-dose schedule. This virtual approach reduced overall expenditures based on retrospective comparison with previous AAD load hospitalizations. We found that a ‘virtual hospitalization’ for AAD loading with remote EM and twice-daily virtual rounding is feasible using existing digital health technologies.
Pulmonary artery augmentation using decellularized equine pericardium (Matrix Patch™): initial single-centre experience
Authors: Murin Peter , Weixler Viktoria H M , Kuschnerus Kira , Romanchenko Olga , Lorenzen Victoria , Nordmeyer Johannes , Cho Mi-Young , Sigler Matthias , Photiadis Joachim 
Published: March 2021

Abstract

OBJECTIVES
The aim of this study was to report our initial experience when using Matrix Patch™ a cell-free equine-derived pericardium for the augmentation of branch pulmonary arteries (PAs) in children.

METHODS
Between September 2016 and September 2019, Matrix Patch was used for the augmentation of branch PAs in 96 patients and implanted in 147 separate locations. The median age at implantation was 3.2 years (interquartile range: 0.9–8.4), and 33% of patients were infants. The patch was used mainly in redo surgeries (89.6%). Intra-procedural feasibility and reinterventions were analysed. Primary end points were death or patch-related reoperation/stent implantation. Explanted patches were stained for recellularization/calcification, or to reveal proliferation/inflammation.

RESULTS
A total of 81 patients, who received patches in 119 separate locations, were followed within a median of 20 months (interquartile range: 10.2–30.2). Patients with early reoperation/stent implantation were excluded from follow-up. No patch-related death was noted. Survival at last follow-up was 88% (95% CI: 78.8–93.7%). Overall probability of freedom from reoperation/stent implantation per location, 12 and 24 months after initial surgery was 85.8% (95% CI: 76.2–91.7%) and 78.7 (95% CI: 65.9–87.2%), respectively. At 20 months, superficial proliferation with discrete macrophage activity was seen in explants; however, no signs of calcification are observed.

CONCLUSIONS
The initial experience with the Matrix Patch in PAs showed comparable results to other xenogeneic patch materials. Long-term follow-up data are needed to prove the desired durability of the patch in different locations.
Poetry in Expanded Translation: Audre Lorde, Theresa Hak Kyung Cha, Harryette Mullen, Don Mee Choi
Authors: Ramayya Nisha 
Published: March 2021

Abstract
In this article, I discuss the politics and poetics of translation in the work of Audre Lorde, Theresa Hak Kyung Cha, Harryette Mullen, and Don Mee Choi, considering each poet's ideas about translation and translation practices, suggesting approaches to reading and thinking about their work in relation to translation and in relation to each other. I ask the following questions: in the selected poets' work, what are the relationships between the movement of people, the removal of dead bodies, and translation practices? How do the poets move between languages and literary forms, and what are the politics and poetics of their movements with regards to migration, dispossession, and death, as well as resistance, refusal, and rebirth? I select these poets because of the ways in which they confront relationships between the history of the English language and literature, imperialism and colonialism, racialisation and racism, gendered experiences and narratives, and their own poetic practices. These histories and experiences do not exist in isolation, nor do the poets attempt to circumscribe their approaches to language, representation, translation, and form from their lived experiences and everyday practices of survival and resistance. The selected poets’ work ranges in form, tone, and argument, but I argue that their refusal to circumscribe politics and poetics pertains to their subject positions and lived experiences as racialised and post/colonial women, and that this refusal is demonstrated in their diverse understandings of translation and translation practices.
Novel electrocardiographic criteria for short QT syndrome in children and adolescents
Authors: Suzuki Hiroshi , Horie Minoru , Ozawa Junichi , Sumitomo Naokata , Ohno Seiko , Hoshino Kenji , Ehara Eiji , Takahashi Kazuhiro , Maeda Yoshichika , Yoshinaga Masao , Tateno Shigeru , Takagi Junichi , Doi Shozaburo , Hoshina Satoshi , Sato Isamu , Ishikawa Taisuke , Makita Naomasa , Chinushi Masaomi , Akazawa Kohei , Nagashima Masami 
Published: March 2021

Abstract

Aims
Although shortening of the corrected QT interval (QTc) is a key finding in the diagnosis of short QT syndrome (SQTS), there may be overlap of the QTc between SQTS patients and normal subjects in childhood and adolescence. We aimed to investigate electrocardiographic findings for differentiation of SQTS patients.

Methods and results
The SQTS group comprised 34 SQTS patients &lt;20 years old, including 9 from our institutions and 25 from previous reports. The control group comprised 61 apparently healthy subjects with an QTc of &lt;360 ms who were selected from 13 314 participants in a school-based screening programme. We compared electrocardiographic findings, including QT and Jpoint-Tpeak intervals (QT and J-Tpeak, respectively), those corrected by using the Bazett’s and Fridericia’s formulae (cB and cF, respectively) and early repolarization (ER) between the groups. QT, QTc by using Bazett’s formula (QTcB), QTc by using Fridericia’s formula (QTcF), J-Tpeak, J-Tpeak cB, and J-Tpeak cF were significantly shorter in the SQTS group than in the control group. On receiver operating characteristic curve analysis, the area under the curve (AUC) was largest for QTcB (0.888) among QT, QTcB, and QTcF, with a cut-off value of 316 ms (sensitivity: 79.4% and specificity: 96.7%). The AUC was largest for J-Tpeak cB (0.848) among J-Tpeak, J-Tpeak cB, and J-Tpeak cF, with a cut-off value of 181 ms (sensitivity: 80.8% and specificity: 91.8%). Early repolarization was found more frequently in the SQTS group than in the control group (67% vs. 23%, P = 0.001).

Conclusion
A QTcB &lt;316 ms, J-Tpeak cB &lt; 181 ms, and the presence of ER may indicate SQTS patients in childhood and adolescence.
On the de Rham–Witt Complex over Perfectoid Rings
Authors: Davis Christopher , Patchkoria Irakli 
Published: March 2021

AbstractFix an odd prime $p$. The results in this paper are modeled after work of Hesselholt and Hesselholt–Madsen on the $p$-typical absolute de Rham–Witt complex in mixed characteristic. We have two primary results. The 1st result is an exact sequence that describes the kernel of the restriction map on the de Rham–Witt complex over $A$, where $A$ is the ring of integers in an algebraic extension of $\textbf{Q}_p$ or where $A$ is a $p$-torsion-free perfectoid ring. The 2nd result is a description of the $p$-power torsion (and related objects) in the de Rham–Witt complex over $A$, where $A$ is a $p$-torsion-free perfectoid ring containing a compatible system of $p$-power roots of unity. Both of these results are analogous to the results of Hesselholt and Madsen. Our main contribution is the extension of their results to certain perfectoid rings. We also provide algebraic proofs of these results, whereas the proofs of Hesselholt and Madsen used techniques from topology.
Knowledge, practices and perceived barriers of physiotherapists involved in disaster management: a cross-sectional survey of Nigeria-based and trained physiotherapists
Authors: Ojukwu Chidiebele P , Eze Obumneke G , Uduonu Ekezie M , Okemuo Adaora J , Umunnah Joseph O , Ede Stephen S , Onuchukwu Chioma L , Anekwu Emelie M , Ezeigwe Anne U 
Published: March 2021

Abstract

Background
Disasters represent substantial health risks to the human population. Proper interventions at all stages of disaster management (DM) are essential for human-related outcomes. The role of physiotherapy in DM should not be underestimated, but unfortunately information on the involvement of physiotherapists in DM is limited in sub-Saharan Africa.

Methods
One hundred and fifty Nigeria-based and trained physiotherapists were recruited to complete a questionnaire investigating the knowledge, practices and perceived barriers of the role of physiotherapists in DM.

Results
Physiotherapists had moderate knowledge of their role at every stage of DM. However, their involvement in specific DM-related activities during various stages of DM in the country was low. Major barriers to the involvement of physiotherapists in DM included a lack of established government policies on the integration of physiotherapists in DM (90.0%) and a lack of specialty clinical practice areas in DM (89.3%). For improved involvement of physiotherapists in DM in Nigeria, respondents recommended creating an awareness of the role of physiotherapists in DM (91.3%), providing continuous education programmes on DM (90.6%) and inclusion of DM in physiotherapy training programmes in Nigeria (90.0%).

Conclusion
Physiotherapists perceived that they are not adequately involved in DM in Nigeria, despite their moderate knowledge of their role during DM.
Calling for “IR as Becoming-Rhizomatic”
Authors: Eun Yong-Soo 
Published: March 2021

Abstract
This article takes reflexive stock on the current state of the discipline of international relations (IR) in order to catalyze a robust debate on diversity in IR knowledge and knowledge production. IR has witnessed a theoretical explosion and proliferation since the 1980s, and pluralism is acknowledged as a legitimate position for producing IR knowledge and theory. As a result, we have now arrived at “a plural, and pluralist,” field, and several IR scholars have observed that the discipline is much healthier as a result. On closer inspection, however, what we find in IR is quantitative (i.e., representational) diversity and closed territoriality, as opposed to qualitative (i.e., ontological) diversity and open territoriality. By reviewing what defines the nature of diversity in artifacts, including the field of knowledge we know as IR, this article shows that territories and codes of knowledge production in IR remain narrowly confined within a few lines of articulation and strata. Furthermore, although IR is often regarded as a plural, and pluralist, field, the article demonstrates that this is true only in terms of actualized knowledge assemblages (e.g., approaches, theories, or research programs), and not the kinds and movement of territories and codes of knowledge production through which those assemblages are actualized. How can we ensure qualitative diversity and open territoriality in the production of IR knowledge? This article takes preliminary steps in addressing this question by calling for IR as “becoming-rhizomatic.”
Development and validation of high definition phenotype-based mortality prediction in critical care units
Authors: Sun Yao , Kaur Ravneet , Gupta Shubham , Paul Rahul , Das Ritu , Cho Su Jin , Anand Saket , Boutilier Justin J , Saria Suchi , Palma Jonathan , Saluja Satish , McAdams Ryan M , Kaur Avneet , Yadav Gautam , Singh Harpreet 
Published: March 2021

Abstract

Objectives
The objectives of this study are to construct the high definition phenotype (HDP), a novel time-series data structure composed of both primary and derived parameters, using heterogeneous clinical sources and to determine whether different predictive models can utilize the HDP in the neonatal intensive care unit (NICU) to improve neonatal mortality prediction in clinical settings.

Materials and Methods
A total of 49 primary data parameters were collected from July 2018 to May 2020 from eight level-III NICUs. From a total of 1546 patients, 757 patients were found to contain sufficient fixed, intermittent, and continuous data to create HDPs. Two different predictive models utilizing the HDP, one a logistic regression model (LRM) and the other a deep learning long–short-term memory (LSTM) model, were constructed to predict neonatal mortality at multiple time points during the patient hospitalization. The results were compared with previous illness severity scores, including SNAPPE, SNAPPE-II, CRIB, and CRIB-II.

Results
A HDP matrix, including 12 221 536 minutes of patient stay in NICU, was constructed. The LRM model and the LSTM model performed better than existing neonatal illness severity scores in predicting mortality using the area under the receiver operating characteristic curve (AUC) metric. An ablation study showed that utilizing continuous parameters alone results in an AUC score of &gt;80% for both LRM and LSTM, but combining fixed, intermittent, and continuous parameters in the HDP results in scores &gt;85%. The probability of mortality predictive score has recall and precision of 0.88 and 0.77 for the LRM and 0.97 and 0.85 for the LSTM.

Conclusions and Relevance
The HDP data structure supports multiple analytic techniques, including the statistical LRM approach and the machine learning LSTM approach used in this study. LRM and LSTM predictive models of neonatal mortality utilizing the HDP performed better than existing neonatal illness severity scores. Further research is necessary to create HDP–based clinical decision tools to detect the early onset of neonatal morbidities.
Tracing the Roots of Samādhi Burial Practice
Authors: McLaughlin Mark 
Published: March 2021

AbstractA Hindu samādhi is a shrine that marks the final resting-place of a realised guru’s body and reflects the traditional understanding that the realised sage’s perfected body should not be cremated but rather should be preserved as a localised instantiation of sacred power. While some scholars speculate that the Hindu samādhi shrine tradition is borrowed from the Sufi dargāh (tomb-shrine) tradition, I argue that the Hindu samādhi burial practice has pre-dargāh roots resonant with the Buddhist stūpa and relic worship tradition. This article charts the development of this samādhi burial practice in regard to three important considerations: the act of taking samādhi, burying the body, and marking the burial site. It is this long-established burial practice that eventually blossoms into a full-fledged worship tradition in part by coming into contact with the Sufi dargāh tradition.
Semantic change and knowledge transmission: Some case studies in the distribution of words in ECCO
Authors: Regan John 
Published: March 2021

AbstractThis article attempts to make good on the affordances of lexical co-association to investigate semantic change in the British eighteenth-century corpus, mindful of the theories of knowledge that have been presented in an adumbrated state above. Pulling back to enquire into the whole of the eighteenth-century printed corpus, and designing tools fit for apprehending and making sense of such a large, impersonal, non-individual view, will result in a complementary picture of how knowledge was structured and transmitted in the eighteenth century compared with individualistic or ‘great man’ narratives of the history of ideas. Taking the eighteenth-century corpus as a field of enquiry (even in light of its various well-known limitations and inherent biases) results of course in a virtually total loss of granularity at the level of close reading, and a consequent turn away from individual texts written by individual people. But what replaces this is the ability to reconstitute structures of semantic expression from that time that are unexaminable at the level of the sentence and the paragraph, the chapter, and the book. As will be demonstrated, we may now make visible the printed, common, and possibly ‘public’ or social structures of meaning. This article’s field of enquiry is the vast common printed semantic storehouse, as opposed to what is laid down by single authors in clauses, sentences, and chapters.
Machine learning the fates of dark matter subhaloes: a fuzzy crystal ball
Authors: Petulante Abigail , Berlind Andreas A , Holley-Bockelmann J Kelly , Sinha Manodeep 
Published: March 2021

ABSTRACT
The evolution of a dark matter halo in a dark matter only simulation is governed purely by Newtonian gravity, making a clean testbed to determine what halo properties drive its fate. Using machine learning, we predict the survival, mass loss, final position, and merging time of subhaloes within a cosmological N-body simulation, focusing on what instantaneous initial features of the halo, interaction, and environment matter most. Survival is well predicted, with our model achieving 94.25 per cent out-of-bag accuracy using only three model inputs (redshift, subhalo-to-host-halo mass ratio, and the impact angle of the subhalo into its host) taken at the time immediately before the subhalo enters its host. However, the mass loss, final location, and merging times are much more stochastic processes, with significant errors between true and predicted quantities for much of our sample. Only five inputs (redshift, impact angle, relative velocity, and the masses of the host and subhalo) determine almost all of the subhalo evolution learned by our models. Generally, subhaloes that enter their hosts at a mid-range of redshifts (z = 0.67–0.43) are the most challenging to make predictions for, across all of our final outcomes. Subhalo orbits that come in more perpendicular to the host are easier to predict, except for in the case of predicting disruption, where the opposite appears to be true. We conclude that the detailed evolution of individual subhaloes within N-body simulations is difficult to predict, pointing to a stochasticity in the merging process. We discuss implications for both simulations and observations.
DNA polymerase D temporarily connects primase to the CMG-like helicase before interacting with proliferating cell nuclear antigen
Authors: Oki Keisuke , Yamagami Takeshi , Nagata Mariko , Mayanagi Kouta , Shirai Tsuyoshi , Adachi Naruhiko , Numata Tomoyuki , Ishino Sonoko , Ishino Yoshizumi 
Published: March 2021

Abstract
The eukaryotic replisome is comprised of three family-B DNA polymerases (Polα, δ and ϵ). Polα forms a stable complex with primase to synthesize short RNA-DNA primers, which are subsequently elongated by Polδ and Polϵ in concert with proliferating cell nuclear antigen (PCNA). In some species of archaea, family-D DNA polymerase (PolD) is the only DNA polymerase essential for cell viability, raising the question of how it alone conducts the bulk of DNA synthesis. We used a hyperthermophilic archaeon, Thermococcus kodakarensis, to demonstrate that PolD connects primase to the archaeal replisome before interacting with PCNA. Whereas PolD stably connects primase to GINS, a component of CMG helicase, cryo-EM analysis indicated a highly flexible PolD–primase complex. A conserved hydrophobic motif at the C-terminus of the DP2 subunit of PolD, a PIP (PCNA-Interacting Peptide) motif, was critical for the interaction with primase. The dissociation of primase was induced by DNA-dependent binding of PCNA to PolD. Point mutations in the alternative PIP-motif of DP2 abrogated the molecular switching that converts the archaeal replicase from de novo to processive synthesis mode.
Jonckheere–Terpstra–Kendall-based non-parametric analysis of temporal differential gene expression
Authors: Iuchi Hitoshi , Hamada Michiaki 
Published: March 2021

AbstractTime-course experiments using parallel sequencers have the potential to uncover gradual changes in cells over time that cannot be observed in a two-point comparison. An essential step in time-series data analysis is the identification of temporal differentially expressed genes (TEGs) under two conditions (e.g. control versus case). Model-based approaches, which are typical TEG detection methods, often set one parameter (e.g. degree or degree of freedom) for one dataset. This approach risks modeling of linearly increasing genes with higher-order functions, or fitting of cyclic gene expression with linear functions, thereby leading to false positives/negatives. Here, we present a Jonckheere–Terpstra–Kendall (JTK)-based non-parametric algorithm for TEG detection. Benchmarks, using simulation data, show that the JTK-based approach outperforms existing methods, especially in long time-series experiments. Additionally, application of JTK in the analysis of time-series RNA-seq data from seven tissue types, across developmental stages in mouse and rat, suggested that the wave pattern contributes to the TEG identification of JTK, not the difference in expression levels. This result suggests that JTK is a suitable algorithm when focusing on expression patterns over time rather than expression levels, such as comparisons between different species. These results show that JTK is an excellent candidate for TEG detection.