bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roads less travelled by—Pleistocene piracy in Washington’s northwestern Channeled Scabland
Authors: Waitt Richard B. 
Published: March 2021

ABSTRACTThe Pleistocene Okanogan lobe of Cordilleran ice in north-central Washington State dammed Columbia River to pond glacial Lake Columbia and divert the river south across one or another low spot along a 230-km-long drainage divide. When enormous Missoula floods from the east briefly engulfed the lake, water poured across a few such divide saddles. The grandest such spillway into the Channeled Scabland became upper Grand Coulee.By cutting headward to Columbia valley, upper Grand Coulee’s flood cataract opened a valve that then kept glacial Lake Columbia low and limited later floods into nearby Moses Coulee. Indeed few of the scores of last-glacial Missoula floods managed to reach it. Headward cutting of an inferred smaller cataract (Foster Coulee) had earlier lowered glacial Lake Columbia’s outlet. Such Scabland piracies explain a variety of field evidence assembled here: apparently successive outlets of glacial Lake Columbia, and certain megaflood features downcurrent to Wenatchee and Quincy basin.Ice-rafted erratics and the Pangborn bar of foreset gravel near Wenatchee record late Wisconsin flood(s) down Columbia valley as deep as 320 m. Fancher bar, 45 m higher than Pangborn bar, also has tall foreset beds—but its gravel is partly rotted and capped by thick calcrete, thus pre-Wisconsin age, perhaps greatly so. In western Quincy basin foreset beds of basaltic gravel dip east from Columbia valley into the basin—gravel also partly rotted and capped by thick calcrete, also pre-Wisconsin. Yet evidence of late Wisconsin eastward flow to Quincy basin is sparse. This sequence suggests that upper Grand Coulee had largely opened before down-Columbia megaflood(s) early in late Wisconsin time.A drift-obscured area of the Waterville Plateau near Badger Wells is the inconspicuous divide saddle between Columbia tributary Foster Creek drainage and Moses Coulee drainage. Before flood cataracts had opened upper Grand Coulee or Foster Coulee, and while Okanogan ice blocked the Columbia but not Foster Creek, glacial Lake Columbia (diverted Columbia River) drained over this saddle at about 654 m and down Moses Coulee. When glacial Lake Columbia stood at this high level so far west, Missoula floods swelling the lake could easily and deeply flood Moses Coulee.Once eastern Foster Coulee cataract had been cut through, and especially once upper Grand Coulee’s great cataract receded to Columbia valley, glacial Lake Columbia stood lower, and Moses Coulee became harder to flood. During the late Wisconsin (marine isotope stage [MIS] 2), only when Okanogan-lobe ice blocked the Columbia near Brewster to form a high lake could Missoula floodwater from glacial Lake Missoula rise enough to overflow into Moses Coulee—and then only in a few very largest Missoula floods. Moses Coulee’s main excavation must lie with pre-Wisconsin outburst floods (MIS 6 or much earlier)—before upper Grand Coulee’s cataract had receded to Columbia valley.
Diffusion Combustion during Interaction of a Supersonic Round Microjet of Air with a Coaxial (Coflowing Ring) Jet of Hydrogen
Authors: Kozlov V. V. , Litvinenko M. V. , Litvinenko Yu. A. , Tambovzev A. S. , Shmakov A. G. 
Published: March 2021

AbstractThe results of experimental investigations of the features of diffusion combustion during the interaction of a round supersonic microjet of air in the center and a coaxial (coflowing ring) jet of hydrogen. Such combustion is accompanied by a number of new phenomena: the formation of a cone-shaped flame near the nozzle сutoff, the locking of the combustion region in this cone, the presence of small-scale supersonic cells in the resulting flow, and the formation of laminar sections and their turbulization.
Direct Cardiac Actions of the Sodium Glucose Co‐Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure‐Overload Heart Failure
Authors: Li Xuan , Lu Qingguo , Qiu Yunguang , do Carmo Jussara M. , Wang Zhen , da Silva Alexandre A. , Mouton Alan , Omoto Ana C. M. , Hall Michael E. , Li Ji , Hall John E. 
Published: March 2021

Background
We determined if the sodium glucose co‐transporter 2 inhibitor empagliflozin attenuates pressure overload‐induced heart failure in non‐diabetic mellitus mice by direct cardiac effects and the mechanisms involved.

Methods and Results
Male C57BL/6J mice (4–6 months of age) were subjected to sham surgeries or transverse aortic constriction to produce cardiac pressure overload. Two weeks after transverse aortic constriction, empagliflozin (10 mg/kg per day) or vehicle was administered daily for 4 weeks. Empagliflozin increased survival rate and significantly attenuated adverse left ventricle remodeling and cardiac fibrosis after transverse aortic constriction. Empagliflozin also attenuated left ventricular systolic and diastolic dysfunction, evaluated by echocardiography, and increased exercise endurance by 36% in mice with transverse aortic constriction‐induced heart failure. Empagliflozin significantly increased glucose and fatty acid oxidation in failing hearts, while reducing glycolysis. These beneficial cardiac effects of empagliflozin occurred despite no significant changes in fasting blood glucose, body weight, or daily urine volume. In vitro experiments in isolated cardiomyocytes indicated that empagliflozin had direct effects to improve cardiomyocyte contractility and calcium transients. Importantly, molecular docking analysis and isolated perfused heart experiments indicated that empagliflozin can bind cardiac glucose transporters to reduce glycolysis, restore activation of adenosine monophosphate‐activated protein kinase and inhibit activation of the mammalian target of rapamycin complex 1 pathway.

Conclusions
Our study demonstrates that empagliflozin may directly bind glucose transporters to reduce glycolysis, rebalance coupling between glycolysis and oxidative phosphorylation, and regulate the adenosine monophosphate‐activated protein kinase mammalian target of rapamycin complex 1 pathway to attenuate adverse cardiac remodeling and progression of heart failure induced by pressure‐overload in non‐diabetic mellitus mice.
Mission Impossible: Karl Neufeld’s Holy War Propaganda Trip to Medina (1915)
Authors: Strohmeier Martin 
Published: March 2021

Abstract
This article deals with Karl Neufeld’s trip to Medina, undertaken in the framework of German efforts to incite insurrections with the aim of destabilizing British rule in the Muslim world. His specific task was to spread propaganda in the Hijaz and the Sudan; he made it only to Medina, from where he was expelled by the Ottoman government after a stay of six weeks. Neufeld’s diary on which this article is mainly based is the only source about how Holy War propaganda was actually disseminated. Therefore, it goes beyond the existing literature and adds new insight into the discussion of German expeditions organized to counter British influence in the Middle East during the First World War. In contrast to most of the other enterprises, Neufeld accomplished certain goals, which does not, however, change the overall picture that the “jihād made in Germany” was a failure.
Materials used include files from the archive of the German Foreign Office (Politisches Archiv, Auswärtiges Amt: pa-aa), the Sudan Archive Durham (Durham University Library: sad), and narrative sources, as well as the pertinent research literature.
The Normativity of Musical Works
Authors: Arbo Alessandro 
Published: March 2021

Abstract
The cases of copyright infringement that occasionally crop up in the world of music raise many interesting questions: what do we mean when we talk about the identity of a musical work and what does such an identity involve? What in fact are the properties that make it something worth protecting and preserving? These issues are not only of legal relevance, they are central to a philosophical discipline that has seen considerable advances over the last few decades: musical ontology. Taking into account its main theoretical models, this essay argues that an understanding of the ontological status of musical works should acknowledge the irreducible ambivalence of music as an “art of the trace” and as a “performative art.” It advocates a theory of the musical work as a “social object” and, more specifically, as a sound artefact that functions aesthetically and which is based on a trace informed by a normative value. Such a normativity is further explored in relation to three primary ways of conceiving and fixing the trace: orality, notation and phonography.
Functional and radiographical results of asymmetrically reconstructed total hip arthroplasty in patients with bilateral dysplastic arthritic hips with one hip Crowe II–III and the other Crowe IV: a retrospective cohort study
Authors: Shen Junmin , Sun Jingyang , Du Yinqiao , Zhang Bohan , Li Tiejian , Zhou Yonggang 
Published: March 2021

Abstract
Background
The study aimed to evaluate the functional and radiographical results of asymmetrically reconstructed total hip arthroplasty in patients with bilateral dysplastic arthritic hips with one hip Crowe II–III and the other hip Crowe IV.

Materials and methods
From April 2006 to April 2019, we evaluated 23 patients who had a reconstruction of one Crowe II–III hip with high hip center (HHC) and the other Crowe IV hip at the anatomical position (H group). The radiographic and clinical outcomes were compared with those of a control group of 19 patients with bilateral dysplasia who had one Crowe IV hip and the contralateral hip both reconstructed in the anatomical position (A group). Medical records and radiographs were reviewed, and a complete follow-up was conducted for all patients.

Results
The mean vertical center of rotation (V-COR) and horizontal center of rotation (H-COR) in the H group were 30.6 ± 5.8 mm and 30.0 ± 5.5 mm, respectively. In the A group, the corresponding values were 14.0 ± 4.3 mm and 23.0 ± 2.3 mm, respectively. A significant difference was found in terms of V-COR and H-COR between the two groups, and no significant difference was shown regarding the cup inclination, abductor lever arm (ALA), ALA ratio, and leg length discrepancy (LLD). Three patients of the H group and four patients of the A group exhibited LLD > 10 mm. All seven patients who had LLD > 10 mm underwent the shortening subtrochanteric osteotomy (SSTO) of the Crowe IV hip. Subgroup analysis based on the presence and absence of SSTO showed that the LLD of the SSTO group was greater than that of the non-SSTO group in both groups, but the difference was only statistically significant in the A group. At the last follow-up, the mean Harris Hip Scores significantly improved in the two groups, and there was no revision during the follow-up period. In the H group, four patients presented with a slight limp and three patients with a moderate limp, while it was six patients and one patient in the A group, respectively.

Conclusions
Asymmetrical reconstruction in patients with bilateral dysplastic arthritic hips with one hip Crowe II–III and the other Crowe IV is acceptable and comparable when compared with bilateral anatomical reconstruction.

Level of evidence
III, retrospective observational study.
Trial registration Chinese Clinical Trail Registry. ChiCTR2000033848
Somatic variants for seed and fruit set in grapevine
Authors: Costantini Laura , Moreno-Sanz Paula , Nwafor Chinedu Charles , Lorenzi Silvia , Marrano Annarita , Cristofolini Fabiana , Gottardini Elena , Raimondi Stefano , Ruffa Paola , Gribaudo Ivana , Schneider Anna , Grando Maria Stella 
Published: March 2021

AbstractBackgroundGrapevine reproductive development has direct implications on yield. It also impacts on berry and wine quality by affecting traits like seedlessness, berry and bunch size, cluster compactness and berry skin to pulp ratio. Seasonal fluctuations in yield, fruit composition and wine attributes, which are largely driven by climatic factors, are major challenges for worldwide table grape and wine industry. Accordingly, a better understanding of reproductive processes such as gamete development, fertilization, seed and fruit set is of paramount relevance for managing yield and quality. With the aim of providing new insights into this field, we searched for clones with contrasting seed content in two germplasm collections.ResultsWe identified eight variant pairs that seemingly differ only in seed-related characteristics while showing identical genotype when tested with the GrapeReSeq_Illumina_20K_SNP_chip and several microsatellites. We performed multi-year observations on seed and fruit set deriving from different pollination treatments, with special emphasis on the pair composed by Sangiovese and its seedless variant locally named Corinto Nero. The pollen of Corinto Nero failed to germinate in vitro and gave poor berry set when used to pollinate other varieties. Most berries from both open- and cross-pollinated Corinto Nero inflorescences did not contain seeds. The genetic analysis of seedlings derived from occasional Corinto Nero normal seeds revealed that the few Corinto Nero functional gametes are mostly unreduced. Moreover, three genotypes, including Sangiovese and Corinto Nero, were unexpectedly found to develop fruits without pollen contribution and occasionally showed normal-like seeds. Five missense single nucleotide polymorphisms were identified between Corinto Nero and Sangiovese from transcriptomic data.ConclusionsOur observations allowed us to attribute a seedlessness type to some variants for which it was not documented in the literature. Interestingly, theVvAGL11mutation responsible for Sultanina stenospermocarpy was also discovered in a seedless mutant of Gouais Blanc. We suggest that Corinto Nero parthenocarpy is driven by pollen and/or embryo sac defects, and both events likely arise from meiotic anomalies. The single nucleotide polymorphisms identified between Sangiovese and Corinto Nero are suitable for testing as traceability markers for propagated material and as functional candidates for the seedless phenotype.
Enhanced home palliative care could reduce emergency department visits due to non-organic dyspnea among cancer patients: a retrospective cohort study
Authors: Hsu Hua-Shui , Wu Tai-Hsien , Lin Chin-Yu , Lin Ching-Chun , Chen Tsung-Po , Lin Wen-Yuan 
Published: March 2021

Abstract
Background
Dyspnea is a common trigger of emergency department visits among terminally ill and cancer patients. Frequent emergency department (ED) visits at the end of life are an indicator of poor-quality care. We examined emergency department visit rates due to dyspnea symptoms among palliative patients under enhanced home palliative care.

Methods
Our home palliative care team is responsible for patient management by palliative care specialists, residents, home care nurses, social workers, and chaplains. We enhanced home palliative care visits from 5 days a week to 7 days a week, corresponding to one to two extra visits per week based on patient needs, to develop team-based medical services and formulate standard operating procedures for dyspnea care.

Results
Our team cared for a total of 762 patients who exhibited 512 ED visits, 178 of which were due to dyspnea (mean ± SD age, 70.4 ± 13.0 years; 49.4% male). Dyspnea (27.8%) was the most common reason recorded for ED visits, followed by pain (19.0%), GI symptoms (15.7%), and fever (15.3%). The analysis of Group A versus Group B revealed that the proportion of nonfamily workers (42.9% vs. 19.4%) and family members (57.1% vs. 80.6%) acting as caregivers differed significantly (P < 0.05). Compared to the ED visits of the Group A, the risk was decreased by 30.7% in the Group B (P < 0.05).

Conclusions
This study proves that enhanced home palliative care with two additional days per week and formulated standard operating procedures for dyspnea could significantly reduce the rate of ED visits due to non-organic dyspnea during the last 6 months of life.
Acceptability and safety of the menstrual cups among Iranian women: a cross-sectional study
Authors: Gharacheh Maryam , Ranjbar Fahimeh , Hajinasab Negar , Haghani Shima 
Published: March 2021

Abstract
Background
Menstrual cup is one of the menstrual management products that is available throughout the world and can be effective in improving women's quality of life by empowering women in menstrual management. Although menstrual cups have recently entered the Iranian market, the use of this product is limited among women. The aim of this study was to determine the acceptability and safety of menstrual cups among Iranian women.

Methods
This is a cross-sectional study conducted in 2020. Iranian women between the ages of 18 and 50 with regular menstrual periods who used the menstrual cup at least for three months were included. Participants were selected through continuous sampling, and they completed a web-based questionnaire including a demographic characteristics form as well as checklists on acceptability and safety through a link sent electronically via social media.

Results
The mean score of the overall satisfaction with the cup was 6.54 ± 0.76, and the leakage had the lowest mean score among the satisfaction items (5.25 ± 1.63). About 83% of participants reported experiencing menstrual cup leakage. Among the reported health risks, the highest mean score was for vaginal pain during removal (23.9%). Most participants (83.9%) were familiar with the cup via social networks and 98.6% recommended this product to other women.

Conclusions
The high level of acceptability and safety of the menstrual cup showed that this product is a suitable alternative for menstrual management in Iranian women. The results of the study help healthcare providers to learn more about the potential advantages and disadvantages of using cup and create trust in the menstrual cup use based on the results of local evidence-based research.
Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China
Authors: Yao Yao , Liu Linxin , Guo Guang , Zeng Yi , Ji John S. 
Published: March 2021

Abstract
Background
The SIRT1 gene was associated with the lifespan in several organisms through inflammatory and oxidative stress pathways. Long-term air particulate matter (PM) is detrimental to health through the same pathways.

Methods
We used the Chinese Longitudinal Healthy Longevity Survey (CLHLS) to investigate whether there is a gene-environment (G × E) interaction of SIRT1 and air pollution on mortality in an older cohort in China. Among 7083 participants with a mean age of 81.1 years, we genotyped nine SIRT1 alleles for each participant and assessed PM2.5 concentration using 3-year average concentrations around each participant’s residence. We used Cox-proportional hazards models to estimate the independent and joint effects of SIRT1 polymorphisms and PM2.5 exposure on all-cause mortality, adjusting for a set of confounders.

Results
There were 2843 deaths over 42,852 person-years. The mortality hazard ratio (HR) and 95% confidence interval (CI) for each 10 μg/m3 increase in PM2·5 was 1.08 (1.05–1.11); for SIRT1_391 was 0.77 (0.61, 0.98) in the recessive model after adjustment. In stratified analyses, participants carrying two SIRT1_391 minor alleles had a significantly higher HR for each 10 μg/m3 increase in PM2.5 than those carrying zero minor alleles (1.323 (95% CI: 1.088, 1.610) vs. 1.062 (1.028, 1.096) p for interaction = 0.03). Moreover, the interaction of SIRT1 and air pollution on mortality is significant among women but not among men. We did not see significant relationships for SIRT1_366, SIRT1_773, and SIRT1_720.

Conclusion
We found a gene-environment interaction of SIRT1 and air pollution on mortality, future experimental studies are warranted to depict the mechanism observed in this study.
Preoperative C-reactive protein and other inflammatory markers as predictors of postoperative complications in patients with colorectal neoplasia
Authors: Alsaif Sufana H. , Rogers Ailín C. , Pua Priscilla , Casey Paul T. , Aherne Geoff G. , Brannigan Ann E. , Mulsow Jurgen J. , Shields Conor J. , Cahill Ronan A. 
Published: March 2021

Abstract
Background
Inflammatory markers are measured following colorectal surgery to detect postoperative complications. However, the association of these markers preoperatively with subsequent postoperative course has not yet been usefully studied.

Aim
The aim of this study is to assess the ability of preoperative C-reactive protein (CRP) and other inflammatory marker measurements in the prediction of postoperative morbidity after elective colorectal surgery.

Methods
This is a retrospective study which catalogs 218 patients undergoing elective, potentially curative surgery for colorectal neoplasia. Preoperative laboratory results of the full blood count (FBC), C-reactive protein (CRP) and carcinoembryonic antigen (CEA) were recorded. Multivariable analysis was performed to examine preoperative variables against 30-day postoperative complications by type and grade (Clavien-Dindo (CD)), adjusting for age, sex, BMI, smoking status, medical history, open versus laparoscopic operation, and tumor characteristics.

Results
Elevated preoperative CRP (≥ 5 mg/L) was significantly predictive of all-cause mortality, with an OR of 17.0 (p < 0.001) and was the strongest factor to predict a CD morbidity grade ≥ 3 (OR 41.9, p < 0.001). Other factors predictive of CD morbidity grade ≥ 3 included smoking, elevated preoperative platelet count and elevated preoperative neutrophil-lymphocyte ratio (OR 15.6, 8.6, and 6.3 respectively, all p < 0.05). CRP values above 5.5 mg/L were indicative of all-cause morbidity (AUC = 0.871), and values above 17.5 mg/L predicted severe complications (AUC = 0.934).

Conclusions
Elevated preoperative CRP predicts increased postoperative morbidity in this patient cohort. The results herein aid risk and resource stratification and encourage preoperative assessment of inflammatory propensity besides simple sepsis exclusion.
Correlation between activated clotting time monitoring and heparin concentration measurement in a patient with antiphospholipid syndrome during cardiac valve surgery: a case report
Authors: Yoshinaga Koichi , Otsuka Yuji , Furukawa Taku , Amitani Shizuka , Kimura Naoyuki , Sanui Masamitsu 
Published: March 2021

Abstract
Background
Anticoagulation management of patients with antiphospholipid syndrome (APS) undergoing cardiac surgery is challenging due to the prolongation of activated clotting time (ACT). Currently, no study has compared the utility of ACT monitoring using the Hemochron Jr. Signature+ and that of heparin concentration management using the Hemostasis Management System (HMS) Plus in patients with APS.

Case presentation
A 71-year-old woman with APS was scheduled to undergo an aortic valve replacement for aortic regurgitation. The ACT was measured using the Hemochron Jr. Signature+, and the heparin concentration was measured concurrently using the HMS Plus. ACT over 480 s corresponded to an adequate heparin concentration during cardiopulmonary bypass. The clinical course was uneventful, and no thrombotic or hemorrhagic complications were observed.

Conclusion
In the present patient with APS, the Hemochron Jr. Signature+ was useful as an anticoagulation management during cardiac valve surgery.