bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between The Loudness Dependence of The Auditory Evoked Potential and Age in Patients With Schizophrenia and Depression
Authors: Jang Kuk-In , Kim Sungkean , Lee Chany , Chae Jeong-Ho 
Published: August 2021

Abstract
Background

The loudness dependence of the auditory evoked potential (LDAEP) reflects serotonin neurotransmission. Abnormality in serotonergic activity is dominant in patients with schizophrenia (SCZ) and major depressive disorder (MDD). Patients with SCZ show weak LDAEPs, reflecting high serotonergic activity. Some patients with MDD show high serotonergic activity. Although the changes in serotonin neurotransmission in the aging brain of SCZ and MDD have been observed, the relationship between central serotonergic activity and age remains unclear. The present study compared LDAEP between patients with SCZ and MDD, and healthy controls (HCs). We further examined whether age correlated with LDAEP and clinical symptoms, controlling usage of serotonin-related drugs.
Methods

A total of 105 patients with SCZ and MDD were enrolled (54 patients with SCZ and 51 patients with MDD). Thirty-five HCs were recruited. LDAEP was measured on midline channels (Fz, FCz, Cz, Pz, and Oz) among 62 electroencephalography channels. Positive and negative symptoms were assessed in patients with SCZ while depression and/or anxiety symptoms were evaluated in patients with MDD and HC.
Results

Patients with SCZ and MDD showed smaller mean LDAEP than that of HC group (p < 0.001). Age was positively correlated with LDAEPs in patients with SCZ and MDD.
Conclusion

Decreased serotonergic activity with aged brain could be indicated by LDAEP in patients with SCZ and MDD. Changes in LDAEP according to age would be a compensatory mechanism across progression of disease in SCZ and MDD.
Extending Seasonal Malaria Chemoprevention To Five Cycles: A Pilot Study of Feasibility and Acceptability in Mangodara District, Burkina Faso
Authors: TRAORE Adama , DONOVAN Laura , SAWADOGO Benoit , WARD Charlotte , SMITH Helen , RASSI Christian , COUNIHAN Helen , JOHANSSON Johanna , RICHARDSON Sol , SAVADOGO Justin Ragnessi , BAKER Kevin 
Published: August 2021

Abstract
BackgroundSeasonal malaria chemoprevention (SMC) involves administering antimalarial drugs at monthly intervals during the high malaria transmission period to children aged 3 to 59 months as recommended by the World Health Organization. Typically, a full SMC course is administered over four monthly cycles from July to October, coinciding with the rainy season. However, an analysis of rainfall patterns suggest that the malaria transmission season is now longer and starting as early as June in the south of Burkina Faso, leading to a rise in cases prior to the first cycle. This study assessed the acceptability and feasibility of extending SMC from four to five cycles to coincide with the earlier rainy season in Mangodara health district.MethodsThe mixed-methods study was conducted between July and November 2019. Quantitative data were collected through end-of-cycle and end-of-round household surveys to determine the effect of the additional cycle on the coverage of SMC in Mangodara. The data were then compared with 22 other districts where SMC was implemented by Malaria Consortium. Eight focus group discussions were conducted with caregivers and community distributors and 11 key informant interviews with community, programme and national-level stakeholders. These aimed to determine perceptions of the acceptability and feasibility of extending SMC to five cycles.Results The extension was perceived as acceptable by caregivers, community distributors and stakeholders due to the positive impact on the health of children under five. However, many community distributors expressed concern over the feasibility, mainly due to the clash with farming activities in June. Stakeholders highlighted the need for more evidence on the impact of the additional cycle on parasite resistance prior to scale-up. End-of-cycle survey data showed no difference in coverage between five SMC cycles in Mangodara and four cycles in the 22 comparison districts.Conclusions The additional cycle should begin early in the day in order to not coincide with the agricultural activities of community distributors. Continuous sensitisation at community level is critical for the sustainability of SMC and acceptance of an additional cycle. Further studies are required to understand the effectiveness, including cost-effectiveness, of tailoring SMC according to the rainy season.
Which One Causes More Anxiety: Pandemic or Cancer?
Authors: Sönmez Özlem , Meeuw Evrim Tezcanli Tjon A , Taşçı Elif Şenocak , Kazancı Hande Büşra , Altınok Ayşe , Toklucu Elvan , Taşçı Yusuf , Aydoğdu Çise , Aydın Ayşegül Bakır , Yüce Sabiha , Oyan Başak 
Published: August 2021

Abstract
Introduction :

We conducted a survey among cancer patients undergoing active oncology treatment to evaluate their psychological wellbeing during COVID-19 pandemic in comparison to healthy individuals and whether the COVID-19 anxiety affected treatment adherence.
Material and Methods

402 participants were included in the study; 193 were cancer patients receiving active treatment while 209 were healthy volunteers. Hospital anxiety and depression scale (HADS) and COVID-19 phobia scale (C19P-S) questionnaires were used.
Results

Patient group had significantly lower CP19-S compared to healthy individuals. Patients’ mean HADS-anxiety score was significantly higher. Mean depression scores were similar between patients and healthy volunteers. There were no treatment deferrals.
Conclusion

Although the pandemic increased levels of anxiety, oncology treatment continued to be a priority for cancer patients.
Effect of Transport Infrastructure Development On Selected Components of The Environment of Inner-City River Valley And The Possibility of Its Revitalization (Lublin, Poland)
Authors: Zubala Tomasz 
Published: August 2021

Abstract
The study covered an urban river valley, strongly transformed due to the transport infrastructure development. The paper evaluates changes in spatial management of the valley section passing through the city centre that occurred during the past two centuries (long and short term phenomena) as well as their effect on selected environmental components. The basic spatial analyses were carried out with the use of specialised software, cartographic materials and photographic and descriptive documentation of the studied area (archival data). The most unfavourable changes in the potential of the valley environment occurred over the past few decades. They are manifested in a considerable deterioration of landscape values as well as the quantity and quality of water resources. Relationship was identified between water quality and intensity of motor vehicle traffic near the river. Despite the progressing urbanisation of the valley, revitalisation procedures can be still carried out and attractive space in the city centre can be created. In order to demonstrate the reasonableness of the presented concept, the paper suggests that urban succession should be incorporated as a term covering time trends and accumulated transformations. It can be helpful in analysing and determining the directions of development in disputable situations.
Factors Affecting Views On Electronic Health Data Sharing：A Survey of Chinese Residents
Authors: He Ying , Li Lun , Wang Weihong 
Published: August 2021

Abstract
Background: China has been promoting electronic health data sharing for years. However, few studies have focused on Chinese residents' views on sharing personal health data or analyzed factors that affect them. This study targets this gap and investigates China's public attitude toward sharing EHRs and the influential factors, including awareness of privacy and security and potential benefits of sharing EHRs. Methods: The survey adopted multi-stage stratified sampling to select residents in Hunan province randomly and received 932 responses. The primary outcome measures were the responses to the 29-item questionnaire evaluating different views on privacy and safety of Electronic Health Record Data Sharing, using a five-point answering scale with the extremes labeled as "poor" and "excellent".Results: Most Chinese residents hold reservations about sharing them. 297（32.18%）were willing to share their healthcare data between institutions; 438(47.45%)supported sharing only for a better healthcare service. The Logistic Regression(αin=0.05,αout=0.10) was used to find out the factors affecting willingness. The results demonstrated that people who hold the following characteristics would be more likely to consent to share EHRs: (1) have EHRs, (2) value potential benefits of sharing EHRs, (3) believe sharing EHRs would improve quality of care, (4)disagree that sharing EHRs would increase the risks of privacy breach, (5)prefer benefits of sharing EHRs than protecting privacy, and (6)work in a healthcare-related position.(likelihood-ratio chi-squared test 274.058 ,P<0.05).Conclusions: The attitude of the Chinese public towards data sharing in electronic health records is influenced by several factors. Our study provides new and solid references for Chinese public opinion on EHRs. Those results may assist related research or benefit public health administration, like formulating policies to improve public acceptance of EHRs and promoting EHRs-based public health services.
Psychosocial Responses To The Outbreak of COVID-19 Infectious Disease Among Health Care Staff in a Referral Hospital in South of Iran
Authors: Esfandiari Atefeh , Kiani Jamileh , Amiri Batool , Sadatboveyr Neda , Daneshi Safieh , Javanmardi Erfan , Darvishi Behnaz , Mahmoodi Marzieh , Beigi Saidee 
Published: August 2021

Abstract
Background: COVID-19 pandemic has been one of the most stressful situations, worldwide in the twenty first century, and healthcare providers, at the frontline of this crisis, have been exposed to high viral loads through their patients. Therefore, in addition to being at risk of contracting the virus they have also been under mental distress. In this study, we assessed how the healthcare providers in Shohadaye-Khalije-Fars hospital, located in Bushehr, Iran, psychosocially reacted to this outbreak and what were their coping mechanisms. Methods: This is a descriptive cross-sectional study which was conducted between March and July 2020. The population were 177 of the providers and staffs in infectious disease and general medicine wards which were selected via simple random sampling method. The online survey was carried out using GHQ-28 mental health and COPE coping skills questionnaires.Results showed that the mean score of mental health symptoms in female participants (mean=28.65 and standard deviation=12.71) were higher than in male participants (mean=23.97 and standard deviation=10.073), which was statistically significant. Using Chi-square test, there was an outstanding correlation between coping methods and gender. The majority of female participants made use of emotional coping mechanisms (70 out of 113 women) while male participants employed problem-oriented techniques (36 out of 64 men). The results of Pearson’s correlation coefficient test revealed that emotion focused and avoidance oriented coping skills were significantly associated with the incidence of mental health illnesses and presentation of anxiety symptoms.Conclusion: The utilization of emotion-oriented and avoidant–oriented coping skills by the healthcare providers and ward staffs aggravated their anxiety symptoms and increased mental health problems in this population during the COVID-19 pandemic. On that account, offering workshops and trainings in regards with coping skills will improve their ability to understand their emotions, detect signs of anxiety early and learn how to manage them in unpredictable stressful situations.
The endoplasmic reticulum adopts two distinct forms of tubules
Authors: Wang Bowen , Zhao Zhiheng , Xiong Michael , Yan Rui , Xu Ke 
Published: August 2021

Abstract
Being the largest and most expansive organelle in the cell, the endoplasmic reticulum (ER) carries diverse key functions from protein and lipid synthesis, protein folding and modification, transport, calcium storage, to organelle interactions1-6. The shaping mechanism of this complex, membrane-bounded organelle is thus of fundamental significance7-21. Using super-resolution microscopy, we uncover the coexistence of two distinct, well-defined forms of ER tubules in the mammalian cell. Whereas an ultrathin form, R1, is consistently covered by the membrane curvature-promoting protein Rtn4, in the second form, R2, Rtn4 curiously appears as two parallel lines at a conserved separation of ~105 nm over long ranges. The two tubule forms together account for ~90% of the total tubule lengths, with either one being dominant in different cell types. The R1-R2 dichotomy and the final tubule geometry are both co-regulated by Rtn4 and the ER sheet-maintaining protein Climp63, which respectively define the edge curvature and lumen height of the R2 tubules to generate a ribbon-like structure of well-defined width. The R1 and R2 tubules undergo active remodeling in the cell as they differently accommodate proteins, with the former effectively excluding ER-luminal proteins and ER-membrane proteins with large intraluminal domains. We thus unveil a dynamic ER-tubule structural dichotomy with intriguing functional implications.
Land Use/ Land Cover Dynamics Study and Prediction In Jaipur City us­ing CA Markov Model Integrated with Road Network
Authors: Mourya Nitesh Kumar , Rafi Sana , Shamoo Saima 
Published: August 2021

Abstract
Land Use Land Cover (LULC) dynamics analysis is critical and should be done regularly. It draws attention to LULC developments that can be addressed before they become unmanageable disasters or circumstances. For the years 2000, 2010, and 2020, LULC change analysis was carried out in Jaipur City, Rajasthan, India. The LULC maps were created using Landsat data through a visual interpretation technique at a scale of 1:50,000. These maps were classified into vegetation, agriculture, built-up areas, barren land, and water bodies. LULC was predicted by extrapolating the current LULC change pattern. Using a Cellular Automata-Markov Chain Model (CA Markov) integrated with road network, the current LULC change trend was extrapolated and utilized to estimate the LULC map for the years 2020, 2030, 2040, and 2050. The strategy was validated by estimating LULC change for 2020 and comparing it to the actual LULC map for that year. The urban area contributed to 4. 75% in 2000 of the total area in Jaipur city. The percentage of area under urban class has increased to 9.68% in 2010 and 12.96% in 2020. The prediction based on 2000-2010 and 2010-2020 has shown an unprecedented decadal growth in the built-up area till 2050. The prediction based on the 2000-2010 period has shown a rise of 92.04 % during 2020-2030, 77.13 % during 2030-2040 and, 64.34 % during 2040-2050. The prediction based on the 2010-2020 period has shown a rise of 102.42% during 2020-2030, 73.56% during 2030-2040 and, 54.47 % during 2040-2050. This study is, therefore, calls for policy interventions to manage population and urban growth.
Lethal and Sublethal Effects of Insecticides Used in Cotton on Harmonia Axyridis
Authors: Neto Dyrson O. A. , Gontijo Pablo C. , CARVALHO Geraldo Andrade 
Published: August 2021

Abstract
The agriculture industry seeks to reconcile control tactics for pest management, necessitating studies of lethal and sublethal effects of insecticides on natural enemies. The effect of six insecticides with diverse modes of action—ethiprole, etofenprox, lambda-cyhalothrin, lambda-cyhalothrin + chlorantraniliprole, pymetrozine, and thiamethoxam + chlorantraniliprole—were evaluated after spraying on eggs, third-instar larvae, pupae, and adults of Harmonia axyridis , a generalist predator in cotton crops. Ethiprole was the only one that had no lethal effect on the predator at any stage of its development; however, it caused sublethal effects when applied to eggs (shortening of the larval phase and lower reproduction). Lambda-cyhalothrin caused high predator mortality after exposure at all stages. Due to the high compatibility between the ladybug H. axyridis and ethiprole, this compound is recommended for use in cotton integrated pest management programs. The other insecticides were harmful in lethal or sublethal tests, and further work in semifield and field conditions is required to confirm if they reduce H. axyridis populations.
Identifying Service Gaps Between Patients and Providers in a Native American Outpatient Clinic
Authors: Dorsey Robert , Claudio David , Velazquez Maria A. , Petersen Polly 
Published: August 2021

Abstract
Background: Native American communities in Montana reservations have reported low-level satisfaction in health services. This research explored if the services provided at a Blackfeet Indian Reservation outpatient clinic were designed to meet patient expectations. Methods: Staff and patient interviews and surveys allowed service expectations to be assessed according to the clinic’s ability to meet those expectations. A total of 48 patients and ten staff members (83% of the staff at this clinic) participated in the study voluntarily. Results: We found a disconnect between what patients anticipate for care and what staff think they are anticipating. We also found a discontent between what staff believes patients need versus what the patients feel is needed. Conclusions: These gaps combine to increase the breach between patient expectations and perceptions of their healthcare services. With better insight that captures what patients are looking for from a service, the potential to meet those needs increases and patients feel that their voice is respected and that they are valued.
Guillain-barre Syndrome and Hemophagocytic Syndrome Heralding the Diagnosis of Diffuse Large B Cell Lymphoma: A Case Report and Literature Review
Authors: Zhou Qiaolin , Li Zhaokun , Xu Fang , Liang Xiaogong , Wang Xingbiao , Su Jing , Tang Yufeng 
Published: August 2021

Abstract
BackgroundCentral nervous system (CNS) lesions and peripheral neuropathy are rare among non-Hodgkin’s lymphoma (NHL) patients. Usually, lymphoma infiltration or local oppression account for CNS or peripheral nerve lesions. The incidence of peripheral neuropathy was reported to be 5%. Guillain-Barre Syndrome (GBS) is rarer and may occur in less than 0.3% of NHL patients. Hemophagocytic syndrome (HPS) is another rare complication of NHL. It was reported that 1% of patients with hematological malignancies suffer from HPS. Diffuse large B cell lymphoma (DLBCL) combined with GBS has been reported in 10 cases to date. Case presentationHerein, we reported the case of a 53-year-old man, who was initially hospitalized for abnormal feeling in lower limbs and urinary incontinence. He was finally diagnosed as DLBCL combined with GBS and HPS after 16 days, which is earlier than previously reported. Immunoglobulin pulse therapy, dexamethasone and etoposide were immediately administered. The neurological symptoms did not improve obviously, but cytopenia was relieved. However, GBS-related clinical manifestations partially recovered after one cycle of R-CHOP (Rituximab-Cyclophosphamide, Hydroxydaunorubicin, vincristine, Prednisone) chemotherapy, and disappeared after six cycles of R-CHOP. Conclusions﻿Literature review indicated that DLBCL patients combined with GBS were usually elderly, more than 80% of patients were male and over 60 years old. GBS could occur before lymphoma is diagnosed or occur after lymphoma is diagnosed or treated. Pathogenesis of GBS remains unclear. Molecular simulation is considered as the main mechanism. For such patients, tumor-related immune activation may be the main pathogenesis, and chemotherapy for lymphoma may be crucial. GBS and HPS heralding the diagnosis of EBV DLBCL is clinically rare. Herein, we reported a rare case and shared our clinical experience. If GBS occurs before lymphoma diagnosis, traditional therapies may be effective. Rapid diagnosis and timely treatment of DLBCL are crucial.
Microrna-342-3p Loaded by Human Umbilical Cord Mesenchymal Stem Cells-derived Exosomes Attenuates Deep Vein Thrombosis by Downregulating EDNRA
Authors: Pan Zhiyu , Chen Qian , Ding Hongjian , Li Huaqing 
Published: August 2021

Abstract
Objectivexosomes (exos) exert biological functions to maintain the dynamic balance of cells and tissues by transferring biological cargo to recipient cells. Thus, this study explored human umbilical cord mesenchymal stem cells (hucMSCs)-derived exo transfer of microRNA (miR)-342-3p in deep vein thrombosis (DVT).MethodsHucMSCs were isolated and transfected with miR-342-3p antagomir/agomir. Then, hucMSCs-exos were extracted and injected into rats with DVT to observe inflammation and pathological damage in thrombotic vein. HucMSCs-exos were co-cultured with human umbilical vein endothelial cells (HUVECs) in vitro to observe angiogenesis. miR-342-3p and endothelin A receptor (EDNRA) expression in rats with DVT, as well as their interaction was analyzed.ResultsmiR-342-3p was downregulated and EDNRA was upregulated in rats with DVT. HucMSCs-exos induced the repair of venous thrombosis and suppressed inflammation and pathological injury in rats with DVT, as well as promoted angiogenesis of HUVECs. Upregulated miR-342-3p delivery by hucMSCs-exos alleviated DVT in rats and improved angiogenesis of HUVECs, while downregulated miR-342-3p performed oppositely. miR-342-3p targeted EDNRA, and the effect of hucMSCs-exos transfer of upregulated miR-342-3p was rescued by overexpressing EDNRA.ConclusionBriefly, miR-342-3p loaded by hucMSCs-exos attenuates DVT by downregulating EDNRA, offering a novel direction to treat DVT.
Evidence for a Pleckstrin Homology Domain-containing Proteins as Novel Class of Leaderless Bacteriocins Transporters
Authors: Pérez-Ramos Adrián , Benachour Abdallah , Drider Djamel 
Published: August 2021

Abstract
Bacteriocins biosynthetic pathway is initiated from an inactive precursor, which is composed of an N-terminal leader peptide attached to a C-terminal pro-peptide. However, leaderless bacteriocins (LLB) do not possess this N-terminal leader peptide, nor undergo post-translational modifications. These atypical bacteriocins are observed to be immediately active after their translation in the cytoplasm. However, although considered to be simple, the biosynthetic pathway of LLB remains to be fully understood. Enterocin DD14 (EntDD14) is a two-peptide LLB produced by Enterococcus faecalis 14, a strain isolated from meconium. In silico analysis of DNA encoding EntDD14 located a cluster of 10 genes ddABCDEFGHIJ, where ddE and ddF encode the peculiar DdE and DdF proteins, carrying pleckstrin homology (PH) domains. These modules are quite common in Eucarya proteins and are known to be involved in intracellular signalling or cytoskeleton organization. To elucidate their role within the EntDD14 genetic determinant, we constructed deletion mutants of the 2 corresponding genes. As a result, the ddE or ddF mutants are unable to externalize EntDD14 outside of the cytoplasm, even though there was clear expression of structural genes ddAB encoding EntDD14, and genes ddHIJ encoding an ABC transporter. Importantly, in these mutant strains (DddE and DddF), EntDD14 was detected by mass spectrometry in the intracellular soluble fraction exerting, upon its accumulation, a toxic effect on the producing strain as revealed by cell-counting and confocal microscopy analysis. Taken together, these results clearly indicate that PH domain-containing proteins, like DdE and DdF, are acting as transporters of the leaderless two-peptide EntDD14.