bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoplatform Self-assembly From Small Molecules of Porphyrin Derivatives for NIR-II Fluorescence Imaging Guided Photothermal-immunotherapy
Authors: Cao Yanbing , Wei De , Yang Lixia , Luo Zijin , Yu Peiwen , Li Hao , Zhang Cao , Liu Xiaolong , Wu Fengshou , Wu Ming , Zeng Yongyi 
Published: September 2021

Abstract
Combinatorial photothermal and immunotherapy have demonstrated great potential to remove primary tumors, suppress metastases, and prevent tumor recurrence. However, this strategy still confronts with many limitations, such as complex components, sophisticated construction and inadequate therapeutic efficacy. In this work, we develop small molecules of porphyrin derivatives (PPor) which can self-assemble into monodispersed nanoparticles without supplement of any other ingredients or surfactants. The formed PPor nanoparticles (PPor NPs) exhibit highly photothermal conversion eﬃciency of 70% and NIR-II luminous abilities originated from the strong intramolecular charge transfer (ICT) effect of D-A structure under 808 nm laser irradiation, thus achieving NIR-II fluorescence imaging guided photothermal therapy (PTT) against primary tumor with a high cure rate. More importantly, tumor-associated antigens (TAAs) together with damage-associated molecular patterns (DAMPs) released from PTT-treated cancer cells are proved to elicit immune responses in some degree. After combination with programmed cell death-1 (PD-1) antibody, a robust systematic antitumor immunity are generated to restrain both primary and abscopal tumors growth, prolong survival, prevent pulmonary metastasis on an aggressive 4T1 murine breast tumor model. Thus, this study provides a promising therapeutic paradigm with porphyrin derivatives nano-assembly as phototheranostic agents for the treatment of aggressive tumor with high efficiency.
Effects of rumen undegradable protein sources on nitrous oxide, methane and ammonia emission from the manure of feedlot-finished cattle
Authors: Coelho Larissa de Melo , Brito Liziane de Figueiredo , Messana Juliana Duarte , Cardoso Abmael da Silva , Carvalho Geovany Macêdo , Torres Rodrigo de Nazaré Santos , Carlos Roberta Souto , Malheiros Euclides Braga , Cruz Mara Cristina Pessôa , Berchielli Telma Teresinha 
Published: September 2021

Abstract
Here, the effects of sources of rumen undegradable protein (RUP) in diets on methane (CH4), nitrous oxide (N2O) and ammonia (NH3) emissions from the manure of feedlot-finished cattle were evaluated. We hypothesized that the use of different RUP sources in diets would reduce N loss via urine and contribute to reduced N2O, CH4 and NH3 emissions to the environment. Nellore cattle received different diets (18 animals/treatment), including soybean meal (SM, RDP source), by-pass soybean meal (BSM, RUP source) and corn gluten meal (CGM, RUP source). The protein source did not affect the N and C concentration in urine, C concentration in feces, and N balance (P > 0.05). The RUP sources resulted in a higher N2O emission than the RDP source (P = 0.030), while BSM resulted in a higher N2O emission than CGM (P = 0.038) (SM = 633, BSM = 2521, and CGM = 1153 g ha− 2 N-N2O); however, there were no differences in CH4 and NH3 emission (P > 0.05). In conclusion, the use of RUP in diets did not affect N excretion of beef cattle or CH4 and NH3 emission from manure, but increased N2O emission from the manure.
An Investigation of Different Factors On Durability of Metakaolin Geopolymer Cement Mortar
Authors: Feng Bowen , Liu Jiesheng , Tongtong Zhang , Yan Xu , Man Zhang , Hao Peng , Xiaoming Tan , Sun Zhengguang 
Published: September 2021

Abstract
In the preliminary part of this research, orthogonal experiments were conducted to identify metakaolin admixture and activator content as the two main influencing factors through four factors that mainly affected the basic properties of metakaolin geopolymer specimens. It is crucial to study the durability of construction materials under harsh environments. Therefore, this experiment mainly tested the anti-permeability, sulfate corrosion resistance, and freezing-thawing resistance of metakaolin geopolymer pastes with different ratio of metakaolin admixture and alkali activators content.The results indicated that with the changes of metakaolin and activator content,both of two anti-permeability curves increased firstly and then decreased.The sulfate corrosion resistance showed that both weight loss curves firstly decreased and then increased trend.Corrosion resistance curves increased first and then decreased in different curing time.Freezing-thawing resistance tests indicated that weight loss rate and strength loss rate declined and then ascended.Moreover,the microscopic SEM and FT-IR experiments were used to more directly reflect the patterns of durability changes.
Aging-In-Place Preference and Institutionalization Among Japanese Older Adults: A 7-Year Longitudinal Study
Authors: Nakagawa Takeshi , Noguchi Taiji , Komatsu Ayane , Ishihara Masumi , Saito Tami 
Published: September 2021

Abstract
Background
In Asia, where autonomous decision-making is not well accepted, little is known about whether and how individuals’ preferences are considered when deciding where they receive care. This study examined the longitudinal association of aging-in-place preference when bedridden with institutionalization among Japanese older adults.
Methods
We analyzed nationally representative data of 1,290 community-dwelling older adults aged 70 and above, applying the multiple imputation method. Baseline data were collected in 1999, shortly before the long-term care insurance system was introduced. The outcome was measured as self- or proxy-reported years of institutionalization over seven years. The explanatory variable was the aging-in-place preference. Participants were asked about their desired place of care (facility, home, or other) when bedridden. Covariates were sociodemographic and health-related factors. We used Cox proportional hazards models and calculated hazard ratios (HRs) with 95% confidence intervals (CIs) to evaluate the association of aging-in-place preference when bedridden with institutionalization.
Results
Seventy-eight respondents (6.0%) were institutionalized during the follow-up period. Compared to individuals preferring to reside in long-term care facilities when bedridden (48.7%), those preferring to stay in their homes (39.6%) were less likely to be institutionalized, even after adjusting for relevant covariates (HR = 0.46, 95% CI 0.27–0.79 for model 1 including residential status; HR = 0.45, 95% CI 0.27–0.76 for model 2 including marital status and co-resident children).
Conclusions
Our findings suggest that individuals’ aging-in-place preferences are considered under the long-term care insurance system. Individuals’ preferences should be shared by families and clinicians when deciding the place of care.
The Comparative Effectiveness of Adult Mosquito Sampling Methods Dealing With Odor-Baited Resting Box Traps in A Malaria-Endemic Area in Southern Iran
Authors: Kazemi Seyed Hassan Moosa , Salari Yousef , Shahosseini Nariman , Fekri Sajad , Raeisi Ahmad , Khosravani Mousa , Safari Reza , Rafatpanah Azam , Asgarian Tahereh Sadat , Sedaghat Mohammad Mehdi 
Published: September 2021

Abstract
Background

Iran is under threat of a potential outbreak of mosquito-borne diseases, such as malaria, Dengue fever, Chikungunya, and Zika. The study aimed to determine the efficiency and sustainability of some adult mosquito sampling methods for designing effective entomological surveillance systems in a malaria endemic area.
Methods

Different rates of tap water, sugar, and yeast (Saccharomyces cerevisiae) were mixed to provide CO2. Anopheles stephensi and Culex pipiens Bandar Abbas strains were reared in the insectary and used for tests. On a lab scale, CO2 orientation experiments were performed using a Y-tube olfactometer on the insectary mosquito strains. In the field trial, human landing catches (HLC), artificial pit shelter (APS), CO2-baited trap (CO2-BT), human and cow odor baited resting boxes (HOBT, COBT), cow urine baited trap (CUBT), and colored un-baited box (UB) were studied in Bandar Abbas, Hormozgan Province, south of Iran. Mean densities of An. stephensi and Cx. pipiens insectary strains, which oriented to CO2 as flowrate of 170, and 300 mL/minute was significantly higher compared to the control group (P < 0.05). The black un-baited inbox resting traps significantly more collected wild mosquito species compared to others colored UB (P ˂ 0.05).
Results

A total of 2722 collected mosquitoes comprises Culex pipiens (48.56%), Anopheles fluviatilis s.l.(14.21%), An. stephensi (11.68%), Cx. theileri (9.95%), Aedes caspius (7.01%), An. dthali (6.79%) An. culicifacies s.l., An. pulcherrimus, An. sergentii,An. superpictus s.l., Cx. sitiens and, Ae.caspius less than 1%. Anopheles stephensi and, An.sergenti were most collected in CUBT. Anopheles fluviatilis s.l. and Ae. caspius were most found in HLC. Anopheles dthali, Cx. pipiens and, Cx. theileri were most abundant in APS.
Conclusions

Black CUBT and APS methods can be suggested as a perfect sampling strategy for malaria vectors surveillance. APS, and HLC methods were found useful to entomological surveillance systems for arboviral and filarial vector-borne diseases. Further modified sampling methods should be devoted to identify more effective sampling methods.
Calibration of Two Validated SARS-CoV-2 Pseudovirus Neutralization Assays for COVID-19 Vaccine Evaluation
Authors: Huang Yunda , Borisov Oleg , Kee Jia Jin , Carpp Lindsay , Wrin Terri , Cai Suqin , Sarzotti-Kelsoe Marcella , McDanal Charlene , Eaton Amanda , Pajon Rolando , Hural John , Posavad Christine , Gill Katherine , Karuna Shelly , Corey Lawrence , McElrath M. Juliana , Gilbert Peter , Petropoulos Christos , Montefiori David 
Published: September 2021

Abstract
Vaccine-induced neutralizing antibodies (nAbs) are key biomarkers considered to be associated with vaccine efficacy. In United States Government-sponsored phase 3 efficacy trials of COVID-19 vaccines, nAbs are measured by two different validated pseudovirus-based SARS-CoV-2 neutralization assays, with each trial using one of the two assays. Here we describe and compare the nAb titers obtained in the two assays. We observe that one assay consistently yielded higher nAb titers than the other when both assays were performed on the World Health Organization’s anti-SARS-CoV-2 immunoglobulin International Standard, COVID-19 convalescent sera, and mRNA-1273 vaccinee sera. To overcome the challenge this difference in readout poses in comparing/combining data from the two assays, we evaluate three calibration approaches and show that readouts from the two assays can be calibrated to a common scale. These results may aid decision-making based on data from these assays for the evaluation and licensure of new or adapted COVID-19 vaccines.
Quality control method of inner surface of valve sleeve in abrasive flow machining
Authors: Li Junye , Sun Liwei , Zhu Zhibao , Song Linsen , Zhao Weihong , Xu Chengyu , Xu Ying 
Published: September 2021

Abstract
The abrasive flow precision machining(AFPM) method is utilized to smooth the inner wall of the valve sleeve. Through the method of large eddy simulation(LES) and a reasonable subgrid model, numerical simulation analysis is performed on the inner surface of the abrasive flow machining (AFM) valve sleeve to predict the material removal efficiency and surface quality. The effects of wall shear force, dynamic pressure, particle pressure, and vortex on the particle flow are analyzed under different processing parameters. The mechanism of precision machining of the inner wall surface of the valve sleeve by abrasive flow is obtained. The experiment of AFPM was performed by response surface methodology. The results show: The processing pressure and the number of abrasive mesh have a significant impact on the AFM. Through the quadratic response surface plot and contour plot, it is found that the roughness has a minimum point and the best process parameters are obtained. After AFPM, the roughness of the inner wall of the valve sleeve can reach 0.218μm. Finally, the roughness prediction model is established by using the analysis of variance method, and the quality control method of the inner wall surface of the valve sleeve is obtained.
A stretchable micromixer with enhanced performance for intermediate Reynolds numbers
Authors: Fallahi Hedieh , Zhang Jun , Nicholls Jordan , Singha Pradip , Nguyen Nhat-Khuong , Ooi Chin Hong , Nguyen Nam-Trung 
Published: September 2021

Abstract

Chemical reactions in microscale require good mixing at a relatively low flowrate. However, mixing in microscale faces the major challenge of stable laminar flow associated with the low Reynolds number, the relative ratio between inertial force and viscous force. For low Reynolds numbers of less than unity, mixing occurs due to molecular diffusion. For high Reynolds number of more than several tens, chaotic advection enhances mixing. However, in the intermediate regime, mixing is not efficient. This paper reports a stretchable micromixer with dynamically tuneable channel dimensions. Periodically stretching the device changes the channel geometry and the curvature induced secondary Dean flows. The dynamically evolving secondary and main flows in the mixing channel result in chaotic advection and enhance mixing. The concept was demonstrated in a stretchable micromixer with a serpentine channel. We evaluated the performance of this stretchable micromixer both experimentally and numerically. At the intermediate range of Reynolds numbers from 4 to 17, the periodically stretched micromixer showed a better mixing efficiency than the non-stretched counterpart. Therefore, our stretchable micromixer is a potential candidate for applications where precious reagents need to be mixed at relatively low flow rate conditions.
Assessing Students' Satisfaction with Library Service Delivery at University of Health and Allied Sciences, Ho
Authors: TSEH ELIAS KORMLA 
Published: September 2021

Abstract
The purpose of the study was to investigate students' satisfaction with service delivery in the University of Health and Allied Sciences (UHAS), Ho. Research survey of students was adopted. Sample size of 151 made up of students from selected departments at UHAS participated in the study. Data from the questionnaire was analyzed using frequency counts and percentages by using Statistical Package for Social Sciences SPSS (version 22). Five areas of service delivery namely: library, ICT, health, transportation, and hostel services were considered in the study. A number of significant findings were made from the study. The results revealed that majority of the students indicated dissatisfaction with health, transport as well as Information and communication Technology services (ICT), while others showed little level of satisfaction with library and hostel services. Again, it was revealed that students' satisfaction with service delivery in terms of library and hostel services significantly differ by other services, while, they show much significant difference in their satisfaction with transport, health and ICT services. It was recommended that the university management should enhance students’ satisfaction by ensuring all services that contribute to academic and social life of students in UHAS are delivered to acceptable and satisfactory standards. Again, it was recommended that the government should provide the necessary financial support or resources to management to meet acceptable standards in service delivery and surveys to assess students’ satisfaction with service delivery should be on regular basis by management to ascertain the satisfaction needs of students.
Formation of earth ethics in the context of technological culture of the late modern era
Authors: Pylypenko Svitlana 
Published: September 2021

Object of research: technological culture as a matrix of interaction of the components of the system "man – society – nature/Earth".
Investigated problem: the substantiation of the meaning of the Ethics of the Earth in the context of technological culture, transforms the moral and value system of the late Modern era and provokes the emergence of the era of Posthumanism.
The main scientific results: the definition of the technological culture of the late Modern era made it possible to determine the existing contradictions in the moral dimension of the existence of man and the Earth. It should be noted that in the context of the technological transformation of the Earth, the existing ethics as a monoparadigm of the Enlightenment does not correspond to the challenges of the beginning of the XXI century. It is emphasized that the ethical dimension of the introduction of technologies into the existence of the Earth is an indispensable component of modern scientific discourse. It is not only about the ethical dimension of technology, but also the importance of the formation of the Ethics of the Earth. This allows to conclude that a person determines its moral position relative to the Earth in the context of the technological transformation of the Earth's existence.
The scope of practical use of the research results: the research results can be used in teaching such normative courses as "Philosophy", "Philosophical Anthropology", "Culturology" for students and undergraduates, graduate students of humanitarian and technical faculties.
Innovative technological product: Ethics of the Earth destroys the concept of the Earth as an object that is external to humans. The anthropological dimension of the Earth testifies to the fact that a person should be clearly aware of the responsibility for its activities, since the existence of the Earth is a condition for the existence of a person.
The scope of using the innovative technological product: the substantiation of the Earth Ethics corresponds to the polyparadigmatic optics of the modern post-non-classical scientific discourse, where a person is one of the constituent parts of the nature / Earth system. The post-non-classical paradigm eliminates the New European anthropocentrism, striking the consequences of which the person of the late Modern era feels. We are talking about environmental and anthropological crises that occur in the space of the Earth in the coordinates of technological culture.
Study of properties of wheat germins and meals and their use in the production of dietary hardtacks
Authors: Pyvovarov Pavlo , Cheremskaya Tetiana , Kolesnikova Maryna , Iurchenko Svitlana , Andrieieva Svitlana 
Published: September 2021

Object of research: technology of production of dietetic hardtacks using germs and meal of wheat germ, by defatting them.
Investigated problem: the process of defatting wheat germ meal not only reduces the total amount of lipids, but also contributes to a change in the ratio of individual fatty acids.
Main scientific results: in order to use wheat germ meal as the main raw material, together with wheat germ in the production of dietetic hardtacks, their amino acid composition, biological value and balance of essential amino acids were studied in comparison with the FAO/WHO standard. The mineral, vitamin and fatty acid composition of the germ and meal of wheat germ has been determined. The results obtained were used in the development of the recipe composition and the technological process for the production of dietetic hardtacks.
The results obtained (calculation of the balance according to the "tryptophan" and "threonine" indices) confirm that wheat germ meal is a valuable raw material that can be used in technologies for the production of high-protein food products.
The moisture-absorbing capacity of wheat germ and meal was studied in order to determine their ability to form dough. It has been established that the best performance is characterized by a mixture of wheat germ meal and wheat germ in a ratio of 80:20.
The ability of digestion by enzymes of the gastrointestinal tract "in vitro" of wheat germ meal proteins has been investigated, which determines the biological value of food products and makes it possible to predict the degree of their utilization by the body.
The field of practical use of the research results: production of dietetic hardtacks in restaurant enterprises, in specialized confectionery shops, as well as within the boundaries of food production
An innovative technological product: the possibility of using valuable secondary raw materials in food production technology – wheat germ and meal, which is a source of high-quality protein, vitamins and minerals. This will make it possible to adjust the nutritional and biological value of flour confectionery products, as well as improve the nutritional structure of consumers of these products.
Scope of application of an innovative technological product: dietetic hardtacks
Peculiarities of public debt management policy in the United States of America: experience for Ukraine
Authors: Moroz Ivanna 
Published: September 2021

The object of research is the policy of public debt management of the United States of America and Ukraine.
The problem solved is the low level of efficiency of the policy of public external and internal debt management of Ukraine in the context of financing economic growth.
The main scientific results: based on the analysis of the policy of public debt management of the United States of America, it has been proved, that the public debt and the US budget deficit should be perceived not as a problem or threat to macroeconomic stability, but as a tool to stimulate economic growth. It is substantiated, that in order to optimize the policy of internal and external public debt management of Ukraine it is expedient to introduce a debt rule, which is based on the program-targeted method of attracting public debt and provides for the use of public borrowing exclusively to finance economic development programs. In this case, Ukraine, following the example of the United States, will be able to achieve sustainable economic growth, because changing the priorities from debt financing of current state budget expenditures to financing capital expenditures will allow the Ukrainian government to develop economic infrastructure, create conditions for high value-added goods and to develop small and medium business, which will ultimately ensure macroeconomic stability and progressive economic development of the state.
The scope of practical use of research results. The results of the study can be used by the Cabinet of Ministers of Ukraine, and in particular by the Ministry of Finance during the formation of the Medium-Term public debt management strategy of Ukraine.
Innovative technological product: The debt rule is based on the program-target method of attraction and use of the state internal and external debt that allows to use effectively the state borrowings for financing of economic growth.
Scope of application of an innovative technological product: Policy of management of the state internal and external debt of Ukraine