bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the levels of headspace volatiles, including acetaldehyde and formaldehyde, in red and white wine following light irradiation
Authors: Kim Se Hyeok , Jung Hyun Jeong , Lee Jae Hwan 
Published: February 2021

AbstractThe effects of fluorescence light irradiation on the changes in the levels of volatiles, especially acetaldehyde and formaldehyde, were determined in red and white wines. Three different red or white wine brands were mixed and subjected to light irradiation for 5 days. Generally, the levels of total volatiles in white wine were higher than those in red wine were and decreased during light irradiation. The level of 1,1,6‐trimethyl‐1,2‐dihydronaphthalene, an aromatic compound commonly found in aging wine, decreased significantly following light irradiation (p < 0.05), whereas those of acetaldehyde and formaldehyde increased significantly in white wine (p < 0.05). Furthermore, the formaldehyde content in white wine was higher than that in red wine. Thus, light irradiation promotes the decomposition of major volatiles to a greater degree in white wine than in red wine. This implies that white wine may require more attention and caution against light exposure than red wine.Practical ApplicationRed and white wines are two globally consumed alcoholic beverages; several factors influence their quality. This study evaluates the effects of light irradiation on the profiles of headspace volatiles, such as formaldehyde and acetaldehydes, which are harmful chemicals. Generally, the levels of total headspace volatiles decreased during storage, while those of acetaldehyde and formaldehyde increased markedly in white wine. This increase in aldehyde levels suggests that wines should not be exposed to light irradiation. The results of this study will help wine producers, distributors, and consumers maintain wines with low contents of acetaldehyde and formaldehyde.
Mica Types as Indication of Magma Nature, Central Anatolia, Turkey
Authors: DENIZ Kiymet 
Published: February 2021

AbstractThis study focuses on the nature of giant micas occurring at the contact between the Özvatan (foid‐bearing) syenites and the metamorphic basement in Central Anatolia. The studied micas are dark greenish‐black in color and crystallized within vein shape like bodies as a narrow lens. The origin and processes responsible for the formation of these independent crystals of the giant micas were investigated by mineralogical, petrographical and geochemical analyses with the use of Confocal Raman Spectroscopy (CRS), Fourier Transform Infrared (FTIR) Spectroscopy, X‐Ray Diffraction (XRD), Polarized Energy Dispersive X‐Ray Fluorescence Spectrometer (PED‐XRF) and Electron Probe Micro Analysis (EPMA). According to XRD, CRS, FTIR and EPMA data, the giant micas are phlogopite. EPMA results reveal that studied mica minerals represent the products of re‐equilibrated primary mica characterized by high MgO and FeO and low Al2O3 and TiO2 contents. The trace element concentrations of the giant micas display similar patterns with the upper crust. The giant micas are crystallized within small cubicles from an alkaline magma and their composition is possibly modified by a mixing event between the crust‐ and mantle‐derived magmas and contaminated at varying extent by the basement metamorphic rocks.
Effectiveness of Standardized Nursing Terminologies for Nursing Practice and Healthcare Outcomes: A Systematic Review
Authors: Zhang Tiantian , Wu Xiaohong , Peng Gangyi , Zhang Qian , Chen Lianhua , Cai Zehua , Ou Huanzhen 
Published: February 2021

AbstractPurposeThis review evaluates the effectiveness of using standardized terminologies in nursing.MethodsA systematic literature review was performed via PubMed, Web of Science, CINAHL, and OVID databases for articles published between January 1973 and September 2020. The Effective Public Health Practice Project's Quality Assessment Tool for Quantitative Studies was used to assess the quality of all included studies.ResultsFourteen studies were selected for data extraction and analysis, which included a total of 24,243 patients and 99 nurses. Of the studies that met the inclusion criteria, the quality of five were of high quality, one was of moderate quality, and eight was of weak quality. All articles were summarized according to two themes: the identification of common outcomes or interventions, and the validation or evaluation of the effectiveness of standard nursing terminology sets.ConclusionStandardized terminologies in nursing help nurses to implement care plans according to nursing procedures, supervise changes in patients' sensitive indicators, improve patients' health outcomes, and contribute to evidence‐based nursing practices and global data resource sharing.Implications for nursing practiceStandardized nursing terminologies have positive effects on clinical practice, are essential for enriching nurses' knowledge, and alter nurses’ attitudes regarding education and guidance, which promotes the clinical application of these terminologies.
Ecological Momentary Assessment of Alcohol Consumption and Its Concordance with Transdermal Alcohol Detection and Timeline Follow‐Back Self‐report Among Adults Experiencing Homelessness
Authors: Mun Eun‐Young , Li Xiaoyin , Businelle Michael S. , Hébert Emily T. , Tan Zhengqi , Barnett Nancy P. , Walters Scott T. 
Published: February 2021

BackgroundStudies of alcohol use presume valid assessment measures. To evaluate this presumption, we examined the concordance of alcohol use as measured by ecological momentary assessment (EMA) self‐reports, transdermal alcohol concentration readings via the Secure Continuous Remote Alcohol Monitor (SCRAM), and retrospective self‐reports via the Timeline Follow‐Back (TLFB) among adults experiencing homelessness.MethodsForty‐nine adults who reported alcohol misuse (mean age = 47, SD = 9; 57% Black; 82% men) were recruited from a homeless shelter. For 4 weeks, alcohol use was assessed: (i) 5 times or more per day by EMA, (ii) every 30 minutes by a SCRAM device worn on the ankle, and (iii) by TLFB for the past month at the end of the study period. There were 1,389 days of observations of alcohol use and alcohol use intensity for 49 participants.ResultsEMA and SCRAM alcohol use data agreed on 73% of days, with an interrater agreement Kappa = 0.46. A multilevel analysis of concordance of 3 measures for alcohol use yielded statistically significant correlations of 0.40 (day level) and 0.63 (person level) between EMA and SCRAM. Alcohol use was detected on 49, 38, and 33% of days by EMA, SCRAM, and TLFB, respectively. For alcohol use intensity, EMA and SCRAM resulted in statistically significant correlations of 0.46 (day level) and 0.78 (person level). The concordance of TLFB with either EMA or SCRAM was weak, especially at the day level.ConclusionsThis is the first study to examine concordance of alcohol use estimates using EMA, SCRAM, and TLFB methods in adults experiencing homelessness. EMA is a valid approach to quantifying alcohol use, especially given its relatively low cost, low participant burden, and ease of use. Furthermore, any stigma associated with wearing the SCRAM or reporting alcohol use in person may be attenuated by using EMA, which may be appealing for use in studies of stigmatized and underserved populations.
Network Meta‐Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID‐19 Pathologies
Authors: Huang Wenfei , Zhou Heping , Hodgkinson Colin , Montero Angelo , Goldman David , Chang Sulie L. 
Published: February 2021

BackgroundThe coronavirus disease 2019 (COVID‐19) pandemic is a worldwide crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Many COVID‐19 patients present with fever in the early phase, with some progressing to a hyperinflammatory phase. Ethanol (EtOH) exposure may lead to systemic inflammation. Network meta‐analysis was conducted to examine possible relationships between EtOH consumption and COVID‐19 pathologies.MethodsMolecules affected by EtOH exposure were identified by analysis with QIAGEN Knowledge Base. Molecules affected by COVID‐19 were identified from studies in MEDLINE, bioRxiv, and medRxiv reporting gene expression profiles in COVID‐19 patients, QIAGEN Coronavirus Network Explorer, and analysis of the RNA‐sequencing data of autopsied lungs of COVID‐19 patients retrieved from the GEO database. Network meta‐analysis was then conducted on these molecules using QIAGEN Ingenuity Pathway Analysis (IPA).ResultsTwenty‐eight studies reporting significant gene expression changes in COVID‐19 patients were identified. One RNA‐sequencing dataset on autopsied lungs of COVID‐19 patients was retrieved from GEO. Our network meta‐analysis suggests that EtOH exposure may augment the effects of SARS‐CoV‐2 infection on hepatic fibrosis signaling pathway, cellular metabolism and homeostasis, inflammation, and neuroinflammation. EtOH may also enhance the activity of key mediators including cytokines, such as IL‐1β, IL‐6, and TNF, and transcription factors, such as JUN and STAT, while inhibiting the activity of anti‐inflammatory mediators including glucocorticoid receptor. Furthermore, IL‐1β, IL‐6, TNF, JUN, and STAT were mapped to 10 pathways predicted to associate with SARS‐CoV‐2 proteins, including HMGB1, IL‐1, and IL‐6 signaling pathways.ConclusionsOur meta‐analyses demonstrate that EtOH exposure may augment SARS‐CoV‐2–induced inflammation by altering the activity of key inflammatory mediators. Our findings suggest that it is important for clinicians to caution patients about the risk of alcohol consumption, which has increased during the COVID‐19 pandemic. The findings also call for further investigation into how alcohol exposure affects viral infections.
Preventive effect of morning light exposure on relapse into depressive episode in bipolar disorder
Authors: Esaki Yuichi , Obayashi Kenji , Saeki Keigo , Fujita Kiyoshi , Iwata Nakao , Kitajima Tsuyoshi 
Published: February 2021

AbstractObjectiveLight therapy has been suggested to have a curative effect on bipolar depression; however, preventive effects of light exposure on depressive episodes remain unclear. This study evaluated whether daytime light exposure in real‐life situations was associated with a preventive effect on relapse into depressive episodes in patients with bipolar disorder.MethodsThis prospective, naturalistic, observational study was conducted in Japan between August 2017 and June 2020. Outpatients with bipolar disorder were objectively evaluated for daytime light exposure over 7 consecutive days using an actigraph that could measure ambient light at baseline assessment and then assessed at 12‐month follow‐up for relapse into mood episodes.ResultsOf 202 participants, 198 (98%) completed follow‐up at 12 months and 78 (38%) experienced relapse into depressive episodes during follow‐up. In a Cox proportional hazards model adjusting for potential confounders, a longer time above 1000 lux at daytime was significantly associated with decrease in relapse into depressive episodes (per log min; hazard ratio, 0.66; 95% confidence interval, 0.50–0.91). In addition, a higher average illuminance and longer time above 1000 lux in the morning exhibited a significant decrease in relapse into depressive episodes (per log lux and per log min; hazard ratio, 0.65 and 0.61; 95% confidence interval, 0.49–0.86 and 0.47–0.78, respectively). The association between daytime light exposure and relapse into manic/hypomanic/mixed episodes was not significantly different.ConclusionA significant association was observed between increased daytime light exposure, mainly in the morning, and decreased relapse into depressive episodes.
Crosstalk between miR‐203 and PKCθ regulates breast cancer stem cell markers
Authors: Salem Sohair , Mosaad Rehab 
Published: February 2021

AbstractIntroductionProtein kinase C theta (PKCθ) is expressed in ER‐negative breast cancer and promotes cancer stem cells (CSCs) phenotype. PKCθ gene (PRKCQ) is predicted to be a target for tumor suppressor miR‐203. Herein, we aim to validate this prediction and evaluate the ability of miR‐203 to inhibit migration of breast cancer cell line enriched with CSCs, MDA‐MB‐231, via PRKCQ targeting.MethodsCells were transfected with miR‐203 mimic, PRKCQ siRNA and negative control; then real‐time PCR, migration assay, western blotting, reporter assay, and chromatin accessibility assay were performed.ResultsOur findings displayed significant decrease in PRKCQ mRNA level and luciferase signals in cells with restored miR‐203 expression, therefore, validated PRKCQ as a direct target of miR‐203. Additionally, inhibiting PRKCQ by siRNA led to significant inhibition of miR‐203 expression and significant decrease of chromatin accessibility at miR‐203 promoter region 466–291 upstream TSS. Both of miR‐203 re‐expression and PRKCQ suppression resulted in altering migration ability of MDA‐MB‐231 through regulating AKT pathway and genes involved in breast cancer stem cells, CD44 and ALDH1A3. Expression of CDK5, GIV, and NANOG was significantly downregulated in miR‐203 mimic‐transfected cells, while PRKCQ siRNA‐transfected cells displayed downregulation of OCT3/4, SOX2, and NANOG. Furthermore, we found that miR‐224 expression was enhanced while miR‐150 was downregulated after ectopic expression of miR‐203.ConclusionThe study highlighted the negative feedback loop between miR‐203 and its target PRKCQ and the interplay between them in regulating genes involved in BCSCs. The study also concluded “microRNA‐mediated microRNA regulation” as an event in breast cancer cells.
Management of patients with atopic dermatitis undergoing systemic therapy during COVID‐19 pandemic in Italy: Data from the DA‐COVID‐19 registry
Authors: Chiricozzi Andrea , Talamonti Marina , De Simone Clara , Galluzzo Marco , Gori Niccolò , Fabbrocini Gabriella , Marzano Angelo Valerio , Girolomoni Giampiero , Offidani Annamaria , Rossi Maria Teresa , Bianchi Luca , Cristaudo Antonio , Fierro Maria Teresa , Stingeni Luca , Pellacani Giovanni , Argenziano Giuseppe , Patrizi Annalisa , Pigatto Paolo , Romanelli Marco , Savoia Paola , Rubegni Pietro , Foti Caterina , Milanesi Nicola , Belloni Fortina Anna , Bongiorno Maria Rita , Grieco Teresa , Di Nuzzo Sergio , Fargnoli Maria Concetta , Carugno Andrea , Motolese Alberico , Rongioletti Franco , Amerio Paolo , Balestri Riccardo , Potenza Concetta , Micali Giuseppe , Patruno Cataldo , Zalaudek Iris , Lombardo Maurizio , Feliciani Claudio , Di Nardo Lucia , Guarneri Fabrizio , Peris Ketty ,   DA‐COVID‐19 study group
Published: February 2021

AbstractBackgroundFew and small studies have described the management of immunomodulant/immunosuppressive therapies or phototherapy in atopic dermatitis (AD) patients during coronavirus disease 2019 (COVID‐19) pandemic.MethodsA national registry, named DA‐COVID‐19 and involving 35 Italian dermatology units, was established in order to evaluate the impact of COVID‐19 pandemic on the management of adult AD patients treated with systemic immunomodulant/immunosuppressive medications or phototherapy. Demographic and clinical data were obtained at different timepoints by teledermatology during COVID‐19 pandemic, when regular visits were not allowed due to sanitary restrictions. Disease severity was assessed by both physician‐ and patient‐reported assessment scores evaluating itch intensity, sleep disturbances, and AD severity.ResultsA total of 1831 patients were included, with 1580/1831 (86.3%) continuing therapy during pandemic. Most patients were treated with dupilumab (86.1%, 1576/1831) that was interrupted in only 9.9% (156/1576) of cases, while systemic immunosuppressive compounds were more frequently withdrawn. Treatment interruption was due to decision of the patient, general practitioner, or dermatologist in 39.9% (114/286), 5.6% (16/286), and 30.1% (86/286) of cases, respectively. Fear of increased susceptibility to SARS‐CoV‐2 infection (24.8%, 71/286) was one of the main causes of interruption. Sixteen patients (0.9%) resulted positive to SARS‐CoV‐2 infection; 3 of them (0.2%) were hospitalized but no cases of COVID‐related death occurred.ConclusionsMost AD patients continued systemic treatments during COVID pandemic and lockdown period, without high impact on disease control, particularly dupilumab‐treated patients.
Childhood vaccination and allergy: A systematic review and meta‐analysis
Authors: Navaratna Samidi , Estcourt Marie J. , Burgess John , Waidyatillake Nilakshi , Enoh Elizabeth , Lowe Adrian J. , Peters Rachel , Koplin Jennifer , Dhamage Shyamali C. , Lodge Caroline J. 
Published: February 2021

AbstractBackground and ObjectiveAs the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy.DesignWe searched the electronic databases PubMed and EMBASE (January 1946‐January 2018) using vaccination and allergy terms.MethodsTwo authors selected papers according to the inclusion criteria. Pooled effects across studies were estimated using random‐effects meta‐analysis. Due to inadequate number of homogeneous publications on newer and underused vaccines, meta‐analysis was limited to allergic outcomes following administration of (Bacillus Calmette‐Guérin) BCG, measles or pertussis vaccination. The review was prospectively registered in the PROSPERO systematic review registry (NO: CRD42017071009).ResultsA total of 35 publications based on cohort studies and 7 publications based on randomized controlled trials (RCTs) met the inclusion criteria. RCTs: From 2 studies, early vaccination with BCG vaccine was associated with a reduced risk of eczema (RR = 0.83; 95% CI = 0.73‐0.93; I2 = 0%) but not food allergy or asthma. No association was found between pertussis vaccine and any allergic outcome based on a single RCT.Cohort studiesChildhood measles vaccination was associated with a reduced risk of eczema (RR = 0.65; 95% CI = 0.47‐0.90, I2 = 0.0%), asthma (RR = 0.78; 95% CI = 0.62‐0.98, I2 = 93.9%) and, with a similar, statistically non‐significant reduction in sensitization (RR = 0.78; 95% CI = 0.61‐1.01, I2 = 19.4%).ConclusionsWe found no evidence that childhood vaccination with commonly administered vaccines was associated with increased risk of later allergic disease. Our results from pooled analysis of both RCTs and cohort studies suggest that vaccination with BCG and measles vaccines were associated with a reduced risk of eczema.
Allergen immunotherapy: The growing role of observational and randomized trial “Real‐World Evidence”
Authors: Paoletti Giovanni , Di Bona Danilo , Chu Derek K. , Firinu Davide , Heffler Enrico , Agache Ioana , Jutel Marek , Klimek Ludger , Pfaar Oliver , Mösges Ralph , DunnGalvin Audrey , Genuneit Jon , Hoffmann Hans Jürgen , Canonica Giorgio Walter 
Published: February 2021

AbstractBackgroundAlthough there is a considerable body of knowledge about allergen immunotherapy (AIT), there is a lack of data on the reliability of real‐world evidence (RWE) in AIT, and consequently, a lack of information on how AIT effectively works in real life.MethodsTo address the current unmet need for an appraisal of the quality of RWE in AIT, the European Academy of Allergy and Clinical Immunology Methodology Committee recently initiated a systematic review of observational studies of AIT, which will use the RELEVANT tool and the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE) to rate the quality of the evidence base as a whole. The next step will be to develop a broadly applicable, pragmatic “real‐world” database using systematic data collection. Based on the current RWE base, and perspectives and recommendations of authorities and scientific societies, a hierarchy of RWE in AIT is proposed, which places pragmatic trials and registry data at the positions of highest level of evidence.Key ResultsThere is a need to establish more AIT registries that collect data in a cohesive way, using standardized protocols.ConclusionsThis will provide an essential source of real‐world data that can be easily shared, promoting evidence‐based research and quality improvement in study design and clinical decision‐making.
Duration of post‐operative antibiotic treatment in acute complicated appendicitis: systematic review and meta‐analysis
Authors: Ramson Dhruvesh M. , Gao Hugh , Penny‐Dimri Jahan C. , Liu Zhengyang , Khong Jacqueline Nguyen , Caruana Carla B. , Campbell Ryan , Jackson Sarah , Perry Luke A. 
Published: February 2021

AbstractBackgroundAppendicitis is the most frequent aetiology of acute abdominal pain requiring surgical treatment, with an estimated lifetime risk between 7% and 8%. Antibiotics play a substantial role in treatment, and there is considerable debate regarding the duration of antibiotics in treating appendicitis.MethodsWe searched multiple databases from inception until June 2019 for peer‐reviewed studies that compared different durations of antibiotic treatment after appendicectomy for acute complicated appendicitis in adults. We dichotomized reported data into short‐ and extended‐term antibiotic use and controlled for different definitional thresholds in the meta‐analysis. We generated risk ratios using restricted maximum likelihood methods and mixed effects modelling for each outcome of interest.ResultsFour observational studies involving 847 participants were included in the meta‐analysis. For the primary outcomes of intra‐abdominal infection, we did not find a statistically significant difference between extended‐ and short‐term antibiotic strategies for intra‐abdominal infection (Risk ratio 0.92, 95% confidence interval (CI) 0.49–1.74). Three randomized controlled trials involving 291 participants were included in a separate meta‐analysis. We found that extended antibiotic usage was not associated with a statistically significant reduced risk for intra‐abdominal infection (RR 0.52, 95% CI 0.21–1.29) or surgical site skin infection (RR 1.44, 95% CI 0.43–4.81).ConclusionThis systematic review and meta‐analysis found that extended post‐operative antibiotic treatment may not be associated with a reduced risk of intra‐abdominal infection; however, meta‐analysis was significantly limited by heterogeneity between studies and underpowered trials. Further large randomized controlled trials are needed to confirm these findings.
Postoperative serum procalcitonin versus C‐reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta‐analysis
Authors: Vasavada Bhavin , Patel Hardik 
Published: February 2021

AbstractBackgroundAim of this meta‐analysis was to compare diagnostic accuracy C‐reactive protein and procalcitonin between postoperative days 3 and 5 to predict infectious complications post pancreatic surgery.MethodsA systemic literature search was performed using MEDLINE, EMBASE and SCOPUS to identify studies evaluating the diagnostic accuracy of procalcitonin and C‐reactive protein to predict infectious complications between postoperative days 3 and 5 following pancreatic surgery. A meta‐analysis was performed using random‐effect model and pooled predictive parameters.ResultsFifteen studies consisting of 2212 patients were included in the final meta‐analysis. Pooled sensitivity, specificity, area under curve and diagnostic odds ratio (DOR) for day 3 C‐reactive protein were 62%, 67%, 0.772 and 6.54, respectively. Pooled sensitivity, specificity, area under curve and DOR for day 3 procalcitonin were 74%, 79%, 0.8453 and 11.03, respectively. Sensitivity, specificity, area under the curve and DOR for day 4 C‐reactive protein were 60%, 68%, 0.8022 and 11.90, respectively. Sensitivity, specificity and DOR of postoperative day 5 procalcitonin level for predicting infectious complications were 83%, 70% and 12.9, respectively. Pooled sensitivity, specificity, Area Under Receiver Operating Curve and DOR were 50%, 70%, 0.777 and 10.19, respectively.ConclusionPostoperative procalcitonin is a better marker to predict postoperative infectious complications after pancreatic surgeries.