bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of customized insoles in the improvement of plantar pressure in patients with diabetic neuropathy: Protocol of a randomized and controlled clinical trial
Authors: Farhat Gabriel , Martins Camila Marinelli , Gomes Ricardo Zanetti , Galvão Letícia Carollyne , Kravutschke Rodolfo Martins , Teixeira Alves Fabiana Bucholdz 
Published: October 2021

OBJECTIVE: To evaluate the influence of customized insoles in the plantar pressure of diabetes patients with neuropathy in comparison to the sham group. METHODS: The work method, duly registered at the Registro Brasileiro de Ensaios Clínicos – REBEC (Clinical Trial Brazilian Register) (http://www.ensaiosclinicos.gov.br/) RBR-5NQK4K, includes a randomized, controlled, prospective, double-blinded clinical trial, with a sample of 46 volunteers that will be randomly randomized in a 1: 1 ratio to be referred to intervention and control groups. The intervention group will receive customized insoles, with a retrocapital bar and an ethyl vinyl acetate plaque (EVA) in the same shape as the retrocapital bar, in order to reduce the pressure on the forefoot. In the control group, flat insoles will be prepared without any therapeutic objective. This project was developed according to the standard protocol for randomized clinical trials (SPIRIT). Along with the clinical evaluation, demographic data of the sample will be collected to identify and confirm the presence of peripheral neuropathy, next, the pedobarographic will be evaluated, and finally, the patients will answer the FAAM questionnaire to assess foot functionality. The primary outcome will be analyzing pressure points in KiloPascal (kPa) in the patients’ feet through pedobarographic of the patients in the intervention and control groups. The secondary outcome will be the foot functionality in activities of daily living through the FAAM (Foot and Ankle Ability Measure), considering the volunteers in the initial evaluation, third and sixth months. FINAL CONSIDERATIONS: Mainly, results of this study will show whether there is a structural alteration in the analysis of the plantar pressure due to the continuous use of insoles and present the evaluation of whether the use of therapeutic insoles improves the foot functionality of the same users when compared to sham insoles.
RELATIONSHIP OF LYMPHOCYTE SUBPOPULATIONS IN BREAST CANCER PATIENTS WITH TREATMENT RESULTS
Authors: Zabotina T. N. , Chertkova A. I. , Borunova A. A. , Zakharova E. N. , Shoua E. K. , Artamonova E. V. , Kovalenko E. I. , Horoshilov M. V. , Kadagidze A. G. 
Published: October 2021

Introduction. Breast cancer (BC) is an immunogenic tumor. Immune cells infiltration of tumor tissue can affect the clinical course of the disease. The immunogenicity of breast cancer varies depending on the molecular subtype.The aim of this work was to study the main indicators of systemic and local immunity before patient’s treatment and to determine their relationship with the immediate neoadjuvant chemotherapy results.Materials and methods. Patients with stage II–III BC received standard neoadjuvant chemotherapy in accordance with the molecular subtypes. The percentage of the main effector and regulatory lymphocytes populations of systemic and local immunity was determined by flow cytometry.Results. A decrease in the level of effector CD8 and CD4 lymphocyte populations and an increase in the level suppressor populations in tumor tissue in comparison with peripheral blood indicate an immunosuppressive state of local immunity in BC patients. In tumor tissue, a high level of CD8+ PD-1+ and CD4+ PD-1+ cells were associated with a high level of regulatory CD4+ CD25highCD127–/low and CD8+ CD11b– CD28– lymphocytes. Differences were found in the significance of individual lymphocyte populations for the immediate results of treatment between patients with different subtypes of breast cancer.Conclusion. Determination of lymphocyte subpopulations correlating with the level of PD-1 cells, and the results of treatment in patients with different molecular BC subtypes, will help a clearer understanding of the antitumor immune response in this pathology, and will also serve as a basis for identifying immune biomarkers that can be used as additional predictive factors in various treatment options for BC patients.
EFFECTS OF 5-HYDROXYPYRIMIDINE DERIVATIVE ON GROWTH AND METASTASIS OF MELANOMA B16 IN C57BL/6 MICE
Authors: Zhurikov R. V. , Kovalenko L. P. , Nikitin S. V. , Durnev A. D. 
Published: October 2021

Introduction. Suppression of activation of an alternative immune response is promising approach of tumor immunotherapy. In this study we evaluated antitumor and antimetastatic activity of SNK-411.Objective. Evaluation of antitumor and antimetastatic activity of 5-hydroxypyrimidine derivative SNK-411 in mouse melanoma B16 model.Materials and methods. Antitumor and antimetastatic activity of the SNK-411 were studied in tests on male C57BL/6 mice using the B16-F10 melanoma model. SNK-411 was injected intraperitoneally at doses of 10 and 25 mg/kg from day 2 to day 15 of melanoma development. Doxorubicin was injected at dose of 4 mg/kg on day 2 of tumor development to act as positive control. Antitumor and antimetastatic activity were studied by calculation of tumor growth inhibition and metastasis inhibition index (MII).Results. SNK-411 at doses of 10 and 25 mg/kg and in combination with single injection of doxorubicin in dose of 4 mg/kg showed antimetastatic activity. MII in SNK-411 at 10 mg/kg dose was 72 %, at dose of 25 mg/kg was 82,9 %. The combination of 14-day course of intraperitoneal injections of SNK-411 at dose of 10 mg/kg and injection of doxorubicin 4 mg/kg revealed MII 97,1 %, in half of mice in this group metastasis were not observed on 21st day of melanoma development. All results are statistically significant. There was no significant inhibition of tumor growth in all groups.Conclusion. SNK-411 has antimetastatic activity in tests on melanoma B16 model. Further investigation is required.
Ku pełnemu uczestnictwu w Eucharystii w okresie pandemii
Authors: Migut Bogusław 
Published: October 2021

Kult chrześcijański jest kultem na wzór Jezusa Chrystusa i w zjednoczeniu z Nim (Rz 12, 1). Dlatego najpełniejszym wyrazem kultu w Kościele jest Eucharystia. W niej uobecnia się sakramentalnie jedyna i raz na zawsze dokonana ofiara Chrystusa, czyli Jego życie w posłuszeństwie i oddaniu się Ojcu, które ma swe spełnienie w śmierci na krzyżu. Uczestnictwo wiernych w Eucharystii polega na naśladownictwie Jezusa w posłuszeństwie Ojcu, czyli na składaniu duchowych ofiar, które Jezus włącza w swą jedyną ofiarę. Uczestnictwo w Eucharystii jako szczególne wyzwanie w okresie pandemii nie tylko ze względu na trudności z fizycznym uczestnictwem, ale też możliwie pełnym uczestnictwem pozasakramentalnym, czyli na odległość. Pierwszym ważnym warunkiem jest pragnienie sakramentalnego uczestnictwa i zjednoczenia z Chrystusem, czyli komunia duchowa. Pomocne w tym są transmisje Mszy przez środki przekazu. Kolejnymi istotnymi warunkami takiego uczestnictwa są towarzyszące mu pragnienie nieustannego nawracania się (ukierunkowanie życia na Boga) oraz zaangażowanie na różnych płaszczyznach w życie Kościoła. Za szczególny filar takiego uczestnictwa pozasakramentalnego należy uznać rozważnie słowa Bożego w formie lectio divina. Wierny ma prawo czytać księgi Pisma św. w dowolnej kolejności. Jednak najbardziej eklezjalną lekturą Biblii jest ta, ukierunkowana na codzienną Eucharystię. Pojedynczy wierny karmi się tym słowem, które danego dnia jest skierowane do całego Kościoła.
Taksā d-h.usāyā. Sakramentalny obrzęd pokuty i pojednania w Asyryjskim Kościele Wschodu
Authors: Potoczny Mateusz 
Published: October 2021

Celem niniejszego artykułu jest zaznajomienie czytelnika z teologią sakramentu pokuty i pojednania w Asyryjskim Kościele Wschodu oraz z wykształconą w łonie tej wspólnoty liturgią jego celebracji zwaną „obrzędem pojednania” (taksā d-h.usāyā). Zaprezentowane badania przeprowadzone zostały w oparciu o syryjską tradycję patrystyczną oraz o najważniejsze źródło liturgiczne, jakim w tym wypadku jest obrzęd, którego redakcję przypisuje się katolikosowi Ishā'Yahbowi III (†659). Analiza obejmuje kolejno teologiczny obraz „odzienia chwały”, który tworzy łączność między sakramentem pokuty a chrztem, sens chrześcijańskiego nawrócenia oraz prezentację obrzędu wraz ze zwróceniem uwagi na jego osobliwości. Studium każe spojrzeć na syro-orientalną celebrację sakramentu jako na obrzęd kompleksowy i teologicznie spójny z intuicją innych wspólnot świata chrześcijańskiego. Wspomniane w studium osobliwości obrzędu wskazują na jego oryginalność i w żaden sposób nie deprecjonują jego teologicznej, liturgicznej czy merytorycznej wartości.
Features of using qualitative interviews with injection drug users
Authors: Artykutsa Serhii , Prokhorova Anna 
Published: October 2021

This article is dedicated to some features of using qualitative interviews when interviewing injection drug users. The main purpose of this article is to give young researchers and all social scientists some important hints and guidelines that would help them when using qualitative interviews for studying injection drug users.
In the first part of the article authors make a literature review concerning specifics and advantages of using qualitative methods for studying specific groups or categories in sociology. However, there are many qualitative methods besides interview, that can be used for studying these groups (focus-groups, observation, content analysis, etc.), authors focus their attention on qualitative interviews as one of the most universal ones, considering its wide-spread use and advantages.
In the second part of the article authors reveal and stress some major points on every stage of qualitative interview: preparation, literature review, methodology development, respondent recruiting, interviewing and analysis. Some of the major points are the understanding of the social and cultural context in which the studied group lives, always paying attention to the senses and meanings that respondent give to concepts that are important to the research, the importance of trust for the injection drug users due to the illegality of their actions that is crucial on both recruitment and interviewing stage, ethical issues concerning confidentiality and anonymity, etc. Also researches in this area include such components as practical recommendations and the ways or steps that could be taken to solve problems related to research problematic. Despite concentrating on the use of one particular method for studying people who use injection drugs, hints and guidelines given in this article can be applied to a wider list of specific respondent’s categories and can even be useful when choosing similar methods.
НЕЙРОНАУЧНЫЕ ИНСТРУМЕНТЫ В СОВРЕМЕННОМ СОЦИОЛОГИЧЕСКОМ ПОЗНАНИИ
Authors: Смирнова Алина Вадимовна 
Published: October 2021

В статье исследуется относительно новое для науки явление – использование нейронаучного инструментария в разнообразных научных дисциплинах (нейроэкономике, культурной нейронауке, нейропедагогике и др.). Приводится пример проектов и инициатив, имеющих место в настоящее время. Особое внимание уделено перспективе применения подобных методов в рамках изучения социально-поведенческих аспектов, в том числе в пределах организационного устройства. Отмечены подходы к пониманию социальной нейронауки и нейросоциологии. Высказаны опасения социологов, которые становятся преградой для активного внедрения прогрессивных методов в традиционную научную область, описан такой феномен, как «биофобия». Рассмотрены публикации, направленные на изучение нейронаучных методов в практической плоскости: отмечены инновационные идеи, которые могут быть реализованными в области работы с персоналом благодаря достижениям нейроменеджмента и нейролидерства. Представлены выводы исследований нейрофизиологических мотивов принятия решений в различных условиях. Отмечены ключевые возражения, которые обычно возникают в отношении нейронаучного инструментария, используемого в рамках изучения поведенческих аспектов. Продемонстрирована краткая характеристика эксперимента, в рамках которого были изучены процессы, описывающие активность головного мозга лидеров ряда профессиональных сфер, также приведены выводы о корреляции соответствующих процессов с практической ролью руководителей. Дается краткий обзор материалов научно-практической конференции, проведенной на тему нейро прожект менеджмента – научной области, направленной на исследование организационных процессов, в которых особую роль играет команда.
Barriers and Resources to Optimize Bone Health in Orthopaedic Education
Authors: Levitt Eli B. , Patch David A. , Ponce Brent A. , Razi Afshin E. , Kates Stephen L. , Patt Joshua C. 
Published: October 2021

Introduction:
Osteoporosis is a critical public health issue with substantial morbidity and healthcare costs. Resident education on osteoporosis is not standardized. Little is known about the barriers to osteoporosis treatment and the usefulness of educational programming from the perspective of orthopaedic residency program directors (PDs).

Methods:
This study aims to evaluate the current state and perception of bone health education from the perspective of orthopaedic residency PDs. Therefore, a self-designed 29-question online survey was sent to 129 PDs in the United States to assess bone health education. The information, collected from August to October 2020, included program characteristics, participation in the American Orthopaedic Association’s Own the Bone (AOA/OTB) program or any fracture liaison service (FLS) program, availability of faculty, potential barriers, and educational resources. Data collection was performed anonymously with a 47% response rate.

Results:
The results were compared between programs that used the AOA/OTB program (30%) or any FLS program (28%) (58% OTB or any FLS) vs. programs that did not have any program (42%). Subsequent subanalysis was performed comparing AOA/OTB vs. any FLS vs. no program. Programs that did not have any FLS were least likely to have a formal education syllabus (p = 0.01). When comparing clinical education of residents on bone health, 64% of programs without any system did not provide any formal clinical exposure such as a bone health clinic vs. assessment in patients with fracture compared with 24% of OTB programs and 44% of programs with any FLS (p = 0.02). When asked about desired resources, 47% would find a bone health rotation useful. Among all PDs, 60% support the concept of a 5-year AOA Council of Orthopaedic Residency Directors (CORD)/OTB osteoporosis curriculum.

Discussion:
The key findings were that institutions including OTB or any FLS in their programs had better availability of specialty consultants, faculty, and a FLS coordinator.
Impact of Sequelae Resulting From the COVID-19 Pandemic on Mental Health: a Cross-sectional Study in Japan and Sweden
Authors: Matsumoto Kazuki , Hamatani Sayo , Shimizu Eiji , Käll Anton , Andersson Gerhard 
Published: October 2021

Abstract
Background: Due to the coronavirus disease 2019 (COVID-19) pandemic, people have undermined their mental health. It has been reported that sequelae resulting from COVID-19 occur at a certain rate. However, information on the mental health of people with sequelae is limited. Thus, this study investigated the relationship between sequelae resulting from COVID-19 and mental health.Methods: Design of the present study was an International and collaborative cross-sectional study in Japan and Sweden from March 18 to June 15, 2021. The analyzed data included 763 adults who participated in online surveys in Japan and Sweden and submitted complete data. In addition to demographic data including terms related to COVID-19, psychiatric symptoms such as depression, anxiety, and post-traumatic stress were measured by using the fear of COVID-19 scale (FCV-19S), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 item (GAD-7), and Impact of Event Scale-Revised (IES-R).Results: of the 135 COVID-19 survivors among the 763 total participants, 40.7% had COVID-19-related sequelae. First, the results of the Bonferroni-corrected Mann Whitney U test showed that the group infected SARS-CoV-2 with sequelae scored significantly higher than those without sequelae and the non-infected group on all clinical symptom scales (P ≤ .001). Next, there was a significant difference that incidence rates of clinical-significant psychiatric symptoms among each group from the results of the Chi-squared test (P ≤ .001). Finally, the results of the multivariate logistic model revealed that the risk of having more severe clinical symptoms were 2.48–4.64 times higher among participants with sequelae. Conclusion: The results showed that approximately half had sequelae after COVID-19 and that the sequelae of COVID-19 may lead to the onset of mental disorders. Trial registration: The ethics committee of Chiba University approved this cross-sectional study (approval number: 4129). However, as no medical intervention was conducted, a clinical trial registration was not necessary.
Label-Free Complete Absorption Microscopy Using Second Generation Photoacoustic Remote Sensing
Authors: Ecclestone Benjamin , Bell Kevan , Sparkes Sarah , Dinakaran Deepak , Mackey John , Reza Parsin Haji 
Published: October 2021

Abstract
In the past decades, absorption modalities have emerged as powerful tools for label-free functional and structural imaging of cells and tissues. Many biomolecules present unique absorption spectra providing chromophore-specific information on properties such as chemical bonding, and sample composition. As chromophores absorb photons the absorbed energy is emitted as photons (radiative relaxation) or converted to heat and under specific conditions pressure (non-radiative relaxation). Modalities like fluorescence microscopy may capture radiative relaxation to provide contrast, while modalities like photoacoustic microscopy may leverage non-radiative heat and pressures. Here we show an all-optical non-contact total-absorption photoacoustic remote sensing (TA-PARS) microscope, which can capture both radiative and non-radiative absorption effects in a single acquisition. The TA-PARS yields an absorption metric proposed as the quantum efficiency ratio (QER), which visualizes a biomolecules proportional radiative and non-radiative absorption response. The TA-PARS provides label-free visualization of a range of biomolecules enabling convincing analogues to traditional histochemical staining of tissues, effectively providing label-free Hematoxylin and Eosin (H&E)-like visualizations. These findings represent the establishment of an effective all-optical non-contact total-absorption microscope for label-free inspection of biological media.
Exploring the Comorbidity Mechanisms Between Asthma and Idiopathic Pulmonary Fibrosis and the Pharmacological Mechanisms of Bu-Shen-Yi-Qi Decoction Therapy via Network Pharmacology
Authors: Zhong Yuanyuan , Hu Lingli , Chen Wenjing , Wang Bin , Dong Jingcheng , Sun Jing 
Published: October 2021

Abstract
Backgrounds. Asthma and idiopathic pulmonary fibrosis (IPF) are common chronic diseases of the respiratory system in clinical practice. However, the relationship and molecular links between them remain unclear, and the current treatment's efficacy is disappointing. Bu-Shen-Yi-Qi (BSYQ) decoction has clinically proved to be effective in treating various chronic airway inflammatory diseases, including asthma and IPF. But the underlying pharmacological mechanisms are still to be elucidated. Methods. This study searched the proteins related to asthma and IPF via TTD, CTD, and DisGeNET database. We then submitted them to the STRING database to establish the protein-protein interaction (PPI) network. The co-bioinformatics analysis was conducted by Metascape. The active ingredients of BSYQ decoction were screened from TCMSP，ETCM，BATMAN-TCM database and HPLC/MS experiment. Then we predicted the corresponding targets based on TCMSP，ETCM, and BATMAN-TCM database. The common targets for asthma and IPF treatment were recognized, and further GO and KEGG analyses were conducted with the DAVID platform. Finally, molecule docking via Autodock Vina was employed to predict the potential binding mode between core potential compounds and targets.Results. One thousand three hundred thirty-three asthma-related targets and 404 IPF-related proteins were retrieved, 120 were overlapped between them, and much of the asthma-related proteins fall into the same statistically significant GO terms with IPF. One hundred sixteen active ingredients of BSYQ decoction were acquired, and 1535 corresponding targets were retrieved. Eighty-three potential compounds and 56 potential targets were recognized for both asthma and IPF treatment. GO and KEGG analysis indicated that the inflammation response, cytokine production, leukocyte differentiation, oxygen level response, etc., were the common pathological processes in asthma and IPF, which were regulated by BSYQ decoction. Molecule docking further predicted the potential binding modes between the core potential compounds and targets.Conclusion. The current study successfully clarified the complex molecule links between asthma and IPF and found the potential common targets between them. Then we demonstrated the efficacy of BSYQ decoction for asthma and IPF treatment from the angle of network pharmacology, which may provide valuable references for further studies and clinical use.
Prevalence of Metabolic Syndrome in Brazilian Adults: A Systematic Review and Meta- Analysis of Published Studies
Authors: Valadares Letícia Teixeira de Siqueira , de Souza Luíza Siqueira Barreto , Júnior Valdir Alves Salgado , Bonomo Larissa de Freitas , de Macedo Leandro Roberto , Silva Maísa 
Published: October 2021

Abstract
BackgroundA cluster of interconnected cardiometabolic risk factors characterizes metabolic Syndrome (MetS). The prevalence of MetS is increasing worldwide, but there is not a meta-analysis of this prevalence in the Brazilian population. We aimed to determine the prevalence of metabolic syndrome among adult general population in Brazil through a meta‑analysis study. MethodsOriginal research studies were searched at PubMed, Scopus, Web of Science, and SciELO databases, from 2011 to 2021. We used the Joanna Briggs Institute tool to assess the quality of included studies. The random effect model was used to estimate the pooled prevalence of MetS. Subgroup and meta-regression analysis were conducted for explored heterogeneity and used the Funnel Plot to assess publication bias. The study was performed based on the criteria of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). ResultsThe search in electronic databases identified 1598 records. From this total, 26 studies were eligible to be included in the final analysis. The overall pooled prevalence among the general population of Brazil was 33% with high heterogeneity observed. By gender, the prevalences were 26% in males and 38% in females. By criteria that was used to define MetS, the prevalence were 31% in NCEP ATP III, 25% in JIS, 37% in IDF/NHLBI/AHA/WHF/IAS/IASO and 33% in IDF criteria. The prevalence in different habitat was 34% in urban, 15% in rural, 28% in quilombola and 37% in indigenous. In different regions was 37% in the South, 30% in Southeast, 38% in North, 31% in Northeast and 39% in Midwest. The pooled prevalence of MetS with age was <45 years: 43% and ≥45 years: 42% and the prevalence based on year of study implementation was 31% in 2015-2019, 35% in 2010-2014 and 28% in 2005-2009. There were no statistically significant differences between subgroups. Most of the studies showed high quality assessment criteria’s except adequate sample size criteria and many studies participants were not sampled in an appropriate way. ConclusionsOur review indicates a high prevalence of MetS in the healthy Brazilian adult population, when compared to others countries and with a world estimate.