bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-pharmacological Home Therapies for Subacute Low Back Pain in Active Duty Military Personnel: A Randomized Controlled Trial
Authors: Talbot Laura A , Webb Lee , Ramirez Vanessa J , Morrell Christopher , Bryndziar Martina , Enochs Kayla , Metter e.jeffrey 
Published: September 2021

ABSTRACTIntroductionLow back pain (LBP) is a major cause of visits to ambulatory care, missed duty time, and disability discharge. The subacute phase of LBP presents an opportune time to prevent chronicity and lessen recurrence. The goal of this randomized controlled trial (RCT) was to determine the relative effectiveness of neuromuscular electrical stimulation (NMES) training and a progressive exercise program (PEP) on improving physical performance, pain, and torso strength in U.S. service members with subacute LBP, compared to standard primary care management (PCM) alone.MethodsThis is an Institutional Review Board–approved protocol for an RCT conducted with active duty military personnel (n = 128) at Fort Campbell, Kentucky, between April 2018 and March 2020. Participants were randomized to receive NMES (n = 43), PEP (n = 42), or PCM (n = 43) for 9 weeks. Outcome measures of physical performance (sit-ups, push-ups, walking, and torso endurance), torso muscle strength (flexion and extension), and pain were assessed at baseline and after 3, 6, and 9 weeks. Analysis was intent-to-treat using linear mixed effects models. A sensitivity analysis was performed to address the protocol deviations that occurred in response to coronavirus disease 2019 pandemic, which required rescheduling 17 in-person study visits to home assessments at 9-week testing.ResultsEvidence was found for group differences in physical performance for sit-ups and push-ups, with NMES showing greater improvement than PCM. The two groups showed similar improvements in torso muscle strength, although the NMES groups may show better improvement during early treatment. No group differences in pain levels were observed during the intervention, and all groups improved during the course of the study period. The amount of NMES muscle stimulation was directly related to the level of improvement, which was not the case for the hours reported for PEP exercise.ConclusionIn an active duty population with subacute LBP, integrating NMES strength training into the rehabilitation therapy may offer a modest benefit for increasing sit-ups and push-ups and improving torso strength.
Cooling and instabilities in colliding flows
Authors: Markwick R N , Frank A , Carroll-Nellenback J , Liu B , Blackman E G , Lebedev S V , Hartigan P M 
Published: September 2021

ABSTRACT
Collisional self-interactions occurring in protostellar jets give rise to strong shocks, the structure of which can be affected by radiative cooling within the flow. To study such colliding flows, we use the AstroBEAR AMR code to conduct hydrodynamic simulations in both one and three dimensions with a power-law cooling function. The characteristic length and time-scales for cooling are temperature dependent and thus may vary as shocked gas cools. When the cooling length decreases sufficiently and rapidly, the system becomes unstable to the radiative shock instability, which produces oscillations in the position of the shock front; these oscillations can be seen in both the one- and three-dimensional cases. Our simulations show no evidence of the density clumping characteristic of a thermal instability, even when the cooling function meets the expected criteria. In the three-dimensional case, the nonlinear thin shell instability (NTSI) is found to dominate when the cooling length is sufficiently small. When the flows are subjected to the radiative shock instability, oscillations in the size of the cooling region allow NTSI to occur at larger cooling lengths, though larger cooling lengths delay the onset of NTSI by increasing the oscillation period.
20 Orbits of binaries based on soar speckle observations
Authors: Gómez Jorge , Docobo José A , Campo Pedro P , Andrade Manuel , Mendez. Rene A , Costa Edgardo 
Published: September 2021

ABSTRACT
New observational data obtained during the 2018, 2019, and 2020 speckle runs with the 4.1-m Southern Astrophysical Research (SOAR) telescope located at Cerro Pachón (Chile) allowed us to recalculate the orbits of the visual binaries: WDS 00277-1625 (YR 1 Aa,Ab), WDS 00462-2214 (RST4155), WDS 03124-4425 (JC 8), WDS 07427-3510 (HDS 1091), WDS 10093+2020 (A2145), WDS 10116+1321 (HU 874 AB), WDS 10217-0946 (BU 25), WDS 11585-2350 (RST 3767 AB), WDS 13117-2633 (FIN 305), WDS 13305+0729 (A 1789), and WDS 16458-0046 (A1141). In addition, we present the first orbits calculated for the following binaries: WDS 07303-5657 (FIN 105), WDS 09110-1929 (I 824), WDS 12111-5302 (HU 1604), WDS 14592-4206 (HDS 2116 Aa,Ab), WDS 15157-2736 (BU 350), WDS 15493+0503 (A 1126), WDS 16402-2800 (VOU 44 AB), and WDS 18126+1224 (HDS 2570). All of them are placed below Dec. + 21° and the majority are main-sequence stars. Except in cases with giant components or close triple systems, the ANAPAR method was used in order to obtain precise dynamical parallaxes and individual masses. These parallaxes were compared with those obtained by Gaia and/or Hipparcos satellites. In the case of FIN 305, we present two different orbital solutions. Also, using the dynamical parallaxes given by these orbits, we have been able to calculate the luminosity of these systems. Said luminosities allow us to indicate an approximate age for the components of these systems, situating them within the Hertzsprung-Russell (HR) diagram. In addition, a commentary for each binary about the physical and dynamical properties of the studied binaries has been included.
Detection of a parsec-scale jet in a radio-quiet narrow-line Seyfert 1 galaxy with highly accreting supermassive black hole
Authors: Yao Su , Yang Xiaolong , Gu Minfeng , An Tao , Yang Jun , Ho Luis C , Liu Xiang , Wang Ran , Wu Xue-Bing , Yuan Weimin 
Published: September 2021

ABSTRACT
The jet in active galactic nuclei (AGN) is a key ingredient in understanding the co-evolution of galaxies and their central supermassive black holes (SMBHs). Unfortunately, the mechanism of jet launching and collimation is still elusive. The observational evidence of decreasing radio loudness with increasing Eddington ratio implies that the jet should be coupled with the accretion process. To further explore the relationship between the jet and accretion, it is necessary to extend our knowledge of the jet to an extreme end of the Eddington ratio distribution of AGN. Using Very Long Baseline Array (VLBA), we report the detection of the parsec-scale radio structure in Mrk 335, a radio-quiet narrow-line Seyfert 1 galaxy with an Eddington ratio close to/above unity. The VLBA image at 1.5 GHz reveals an elongated structure extending ∼20 pc in north–south direction with a peak flux density of 1.98 ± 0.05 mJy beam−1 and radio brightness temperatures as high as 6 × 107 K. This feature provides a strong evidence of a parsec-scale (bipolar) jet launched from a highly accreting SMBH. We discuss the result by comparing Mrk 335 with other highly accreting systems, e.g. Galactic black holes and tidal disruption events, and recall the discovery of collimated corona in the vicinity of SMBH in Mrk 335 by previous X-ray observations, whose relation to the parsec-scale radio jet should be explored by future simultaneous X-ray spectroscopy and high resolution radio observations.
Planet-driven density waves in protoplanetary discs: Numerical verification of non-linear evolution theory
Authors: Cimerman Nicolas P , Rafikov Roman R 
Published: September 2021

ABSTRACT
Gravitational coupling between protoplanetary discs and planets embedded in them leads to the emergence of spiral density waves, which evolve into shocks as they propagate through the disc. We explore the performance of a semi-analytical framework for describing the non-linear evolution of the global planet-driven density waves, focusing on the low planet mass regime (below the so-called thermal mass). We show that this framework accurately captures the (quasi-)self-similar evolution of the wave properties expressed in terms of properly rescaled variables, provided that certain theoretical inputs are calibrated using numerical simulations (an approximate, first principles calculation of the wave evolution based on the inviscid Burgers equation is in qualitative agreement with simulations but overpredicts wave damping at the quantitative level). We provide fitting formulae for such inputs, in particular, the strength and global shape of the planet-driven shock accounting for non-linear effects. We use this non-linear framework to theoretically compute vortensity production in the disc by the global spiral shock and numerically verify the accuracy of this calculation. Our results can be used for interpreting observations of spiral features in discs, kinematic signatures of embedded planets in CO line emission (‘kinks’), and for understanding the emergence of planet-driven vortices in protoplanetary discs.
How stars formed in warps settle into (and contaminate) thick discs
Authors: Khachaturyants Tigran , Beraldo e Silva Leandro , Debattista Victor P 
Published: September 2021

ABSTRACT
In recent years star formation has been discovered in the Milky Way’s warp. These stars formed in the warp (warp stars) must eventually settle into the plane of the disc. We use an N-body+smooth particle hydrodynamics model of a warped galaxy to study how warp stars settle into the disc. By following warp stars in angular momentum space, we show that they first tilt to partially align with the main disc in a time-scale of ${\sim} 1\mbox{$\, {\rm Gyr}$}$. Then, once differential precession halts this process, they phase mix into an axisymmetric distribution on a time-scale of ${\sim} 6 \mbox{$\, {\rm Gyr}$}$. The warp stars end up contaminating the geometric thick disc. Because the warp in our fiducial simulation is growing, the warp stars settle to a distribution with a negative vertical age gradient as younger stars settle further from the mid-plane. While vertically extended, warp star orbits are still nearly circular and they are therefore subject to radial migration, with a net movement inwards. As a result warp stars can be found throughout the disc. The density distribution of a given population of warp stars evolves from a torus to an increasingly centrally filled-in density distribution. Therefore we argue that, in the Milky Way, warp stars should be found in the Solar Neighbourhood. Moreover, settled warp stars may constitute part of the young flaring population seen in the Milky Way’s outskirts.
Measuring sloshing, merging, and feedback velocities in the Virgo cluster
Authors: Gatuzz Efrain , Sanders J S , Dennerl K , Pinto C , Fabian A C , Tamura T , Walker S A , ZuHone J 
Published: September 2021

ABSTRACT
We present a detailed analysis of the velocity structure of the Virgo cluster using XMM–Newton observations. Using a novel technique which uses the Cu K α instrumental line to calibrate the EPIC-pn energy scale, we are able to obtain velocity measurements with uncertainties down to Δv ∼ 100 km s−1. We created 2D projected maps for the velocity, temperature, metallicity, density, pressure, and entropy with an spatial resolution of 0.25 arcmin. We have found that in the innermost gas there is a high velocity structure, most likely indicating the presence of an outflow from the AGN while our analysis of the cluster cool core using RGS data indicates that the velocity of the gas agrees with the M87 optical redshift. An overall gradient in the velocity is seen, with larger values as we move away from the cluster core. The hot gas located within the western radio flow is redshifted, moving with a velocity ∼331 km s−1 while the hot gas located within the eastern radio flow is blueshifted, with a velocity ∼258 km s−1, suggesting the presence of backflows. Our results reveal the effects of both AGN outflows and gas sloshing, in the complex velocity field of the Virgo cluster.
An accurate comprehensive approach to substructure – I. Accreted subhaloes
Authors: Salvador-Solé Eduard , Manrique Alberto , Botella Ignacio 
Published: September 2021

ABSTRACT
This is the first of a series of three papers devoted to the study of halo substructure in hierarchical cosmologies by means of the CUSP formalism. In the present paper, we derive the properties of subhaloes and diffuse dark matter (dDM) accreted on to haloes and their progenitors. Specifically, we relate the dDM present at any time in the inter-halo medium of the real Universe or a cosmological simulation with the corresponding free-streaming mass or the halo resolution mass, respectively, and establish the link between subhaloes and their seeds in the initial density field. By monitoring the collapse and virialization of haloes, we derive from first principles and with no single free parameter the abundance and radial distribution of dDM and subhaloes accreted on to them. Our predictions are in excellent agreement with the results of simulations, but for the predicted fraction of accreted dDM, which is larger than reported in previous works as they only count the dDM accreted on to the final halo, not on to its progenitors. The derivation pursued here clarifies the origin of some key features of substructure. Overall, our results demonstrate that CUSP is a powerful tool for understanding halo substructure and extending the results of simulations to haloes with arbitrary masses, redshifts, and formation times in any hierarchical cosmology endowed with random Gaussian density perturbations.
Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation
Authors: Lanzafame Manuela , Branca Giulia , Landi Claudia , Qiang Mingyue , Vaz Bruno , Nardo Tiziana , Ferri Debora , Mura Manuela , Iben Sebastian , Stefanini Miria , Peverali Fiorenzo A , Bini Luca , Orioli Donata 
Published: September 2021

Abstract
CSA and CSB proteins are key players in transcription-coupled nucleotide excision repair (TC-NER) pathway that removes UV-induced DNA lesions from the transcribed strands of expressed genes. Additionally, CS proteins play relevant but still elusive roles in other cellular pathways whose alteration may explain neurodegeneration and progeroid features in Cockayne syndrome (CS). Here we identify a CS-containing chromatin-associated protein complex that modulates rRNA transcription. Besides RNA polymerase I (RNAP1) and specific ribosomal proteins (RPs), the complex includes ferrochelatase (FECH), a well-known mitochondrial enzyme whose deficiency causes erythropoietic protoporphyria (EPP). Impairment of either CSA or FECH functionality leads to reduced RNAP1 occupancy on rDNA promoter that is associated to reduced 47S pre-rRNA transcription. In addition, reduced FECH expression leads to an abnormal accumulation of 18S rRNA that in primary dermal fibroblasts from CS and EPP patients results in opposed rRNA amounts. After cell irradiation with UV light, CSA triggers the dissociation of the CSA–FECH–CSB–RNAP1–RPs complex from the chromatin while it stabilizes its binding to FECH. Besides disclosing a function for FECH within nucleoli, this study sheds light on the still unknown mechanisms through which CSA modulates rRNA transcription.
huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level
Authors: Wu Lize , Xue Ziwei , Jin Siqian , Zhang Jinchun , Guo Yixin , Bai Yadan , Jin Xuexiao , Wang Chaochen , Wang Lie , Liu Zuozhu , Wang James Q , Lu Linrong , Liu Wanlu 
Published: September 2021

AbstractT-cell receptors (TCRs) and B-cell receptors (BCRs) are critical in recognizing antigens and activating the adaptive immune response. Stochastic V(D)J recombination generates massive TCR/BCR repertoire diversity. Single-cell immune profiling with transcriptome analysis allows the high-throughput study of individual TCR/BCR clonotypes and functions under both normal and pathological settings. However, a comprehensive database linking these data is not yet readily available. Here, we present the human Antigen Receptor database (huARdb), a large-scale human single-cell immune profiling database that contains 444 794 high confidence T or B cells (hcT/B cells) with full-length TCR/BCR sequence and transcriptomes from 215 datasets. All datasets were processed in a uniform workflow, including sequence alignment, cell subtype prediction, unsupervised cell clustering, and clonotype definition. We also developed a multi-functional and user-friendly web interface that provides interactive visualization modules for biologists to analyze the transcriptome and TCR/BCR features at the single-cell level. HuARdb is freely available at https://huarc.net/database with functions for data querying, browsing, downloading, and depositing. In conclusion, huARdb is a comprehensive and multi-perspective atlas for human antigen receptors.
“Craniotomy Within Craniotomy” Technique for Safe Resection of an Intracranial Arteriovenous Malformation With Frontal Bony Erosion: 2-Dimensional Operative Video
Authors: Khorasanizadeh MirHojjat , Ravina Kristine , Filippidis Aristotelis , Ogilvy Christopher S 
Published: September 2021

Abstract
Surgical resection is one option in the treatment of large high-grade brain arteriovenous malformations (AVMs). Resection of AVMs with skull-eroding components can be challenging due to the risk of excessive bleeding from these components during craniotomy and bone flap removal. We present a case of a 25-yr-old woman who presented with an acute onset right-sided frontal headache. She was found to have a large, frontal Spetzler-Martin grade IV AVM with an associated dural AVM. The AVM had caused focal erosions of the right frontal bone by a venous varix traversing the region of the calvarial defect. An elective staged endovascular embolization followed by surgical resection was recommended considering the patient's young age and the large size of the AVM located in a noneloquent area. Given the high risk of intraoperative hemorrhage during the craniotomy portion of the procedure, a “craniotomy within craniotomy” approach was planned. During this approach, a small rectangle of bone, including the portion eroded by the venous varix, was left in place, while the larger bone flap surrounding it was removed for an initial approach to the AVM. The small bony piece was safely removed at later stages of resection once the arterial feeders had been reasonably obliterated. Immediate postoperative catheter angiogram demonstrated good filling of the intracranial vascular territories with no residual AVM. The patient developed mild left facial and left hand weakness postoperatively, which resolved after 2 wk of follow-up. The patient remained neurologically intact on further follow-up.
Technique for Treatment of a Symptomatic Intracranial Stenosis With Balloon Angioplasty and Wingspan Stent Placement: 3-Dimensional Operative Video
Authors: Cotton Patrick C , Kan Peter 
Published: September 2021

Abstract
Intracranial angioplasty and stenting is an increasingly common modality to treat intracranial atherosclerosis, which accounts for 80 000 strokes annually. Early trials showed there to be a high complication rate
1,2
associated with stenting but with improved technique this complication rate has dramatically decreased.
3
The following video details the procedure of intracranial balloon angioplasty and stenting for a high-grade stenosis of the right internal carotid artery. The risks and benefits of the procedure were discussed with the patient and they consented to the procedure.
Clipping of Multiple Cerebral Aneurysms Through Cranioorbital Zygomatic Approach: 2-Dimensional Operative Video
Authors: Almefty Rami O , Ibn Essayed Walid , Al-Mefty Ossama 
Published: September 2021

Abstract
Ruptured cerebral aneurysm is a grave disease, with a high morbidity and mortality, mandating securing the aneurysm to eliminate fatal rebleeding.
1
Multiple aneurysms are frequent and may occur in approximately 20% of the cases with female prominence.
2
The risk of subarachnoid hemorrhage in unruptured aneurysms is higher in patients who had prior ruptured aneurysms.
3
Hence, there is an indication of treating all concomitant aneurysms when one is ruptured. We present the case of clipping of 3 aneurysms via a cranioobritozygomatic (COZ) approach including a middle cerebral artery, anterior choroidal artery, and superior cerebellar artery in a patient presenting with subarachnoid hemorrhage and multiple aneurysms with suboptimal morphology for endovascular coiling. We highlight the advantages of the COZ in the clipping of complex posterior circulation aneurysms and the advantage of mobilization of neural structures to gain wider exposure.
4-6
The temporal fossa space provided by zygomatic osteotomy allows the outward mobilization of the temporal lobe after freeing it by splitting the Sylvian fissure. The falciform ligament is opened overlying the optic nerve, allowing for safe dissection within the opticocarotid window. The oculomotor nerve is detethered from the dura surrounding its entry into the cavernous sinus. These maneuvers allow for mobilization of the critical neurovascular structures, which widens the operative corridor without undue traction or retraction. The COZ with clinoidectomy shortens and widens the operative field, allows for enhanced maneuverability, improved visualization, and exposure of the clinoidal carotid, and facilitates the release and mobilization of the optic and third nerve. The patient consented to surgery.
Image at 1:40 reprinted with permission from Al-Mefty O, Operative Atlas of Meningiomas. Vol 1, © LWW, 1998.
Giant Ossified Clival Chondrosarcoma Resection: 2-Dimensional Operative Video
Authors: Ibn Essayed Walid , Al-Mefty Ossama 
Published: September 2021

Abstract
Chondrosarcomas are a spectrum of tumors with variable clinical behavior, histologically classified as grades I, II, and III.
1
Maximal surgical resection with adjuvant radiation is the gold standard for grade III malignant tumors.
2,3
Lower-grade skull base chondrosarcomas have a slow progressive local growth pattern with an overall benign profile.
1,4
In these grade I and II tumors, radical resection can be sufficient in achieving long-term control of the disease without the need for adjuvant therapy, thus avoiding the long-term side effects of irradiation in relatively young patients.
4,5
As a slow-growing tumor, skull base chondrosarcoma might reach a giant size with progressive neurological deficits prior to diagnosis. In these cases, to achieve maximal resection, skull base approaches tailored to the patient's anatomy are essential.
4,6
Cranial approach is frequently needed due to the calcified nature of part of the tumor that is not amenable to resection through the endonasal approach. The endoscope is extremely helpful combined with the microscopic resection. We demonstrate these techniques through in the surgery of a 39-yr-old female who presented with progressive neurological deficits from a giant ossified chondrosarcoma and underwent a combined petrosal approach for the resection of her tumor. A postoperative small enhancement remained stable on the 4-yr follow-up exam. The pathology confirmed grade II chondrosarcoma, with the patient recovering from her neurological deficit except the third nerve. The patient consented to the surgery and publication of images.
Image at 1:36 reprinted with permission from Al-Mefty O, Operative Atlas of Meningiomas. Vol 1, ©LWW, 1998.