bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unfolding of spatial representation at systems level in infant rats
Authors: Shan Xia , Contreras María P. , Mendez Marta , Born Jan , Inostroza Marion 
Published: November 2021

AbstractSpatial representations enable navigation from early life on. However, the brain regions essential to form spatial representations, like the hippocampus, are considered functionally immature before weaning. Here, we examined the formation of representations of space in rat pups on postnatal day (PD) 16, using a simple habituation paradigm where the pups were exposed to an arena on three occasions, separated by ~140 min. Whereas on the first two occasions the arena was the same, on the third “test” occasion either proximal cues (Prox group), or distal cues (Dist group), or proximal and distal cues (Prox‐Dist group), or no cues (No‐change group) were rearranged. Locomotion (distance traveled) was used as behavioral measure of habituation, and c‐Fos expression to measure regional brain activity at test. Locomotion generally decreased across the first two occasions. At test, it reached a minimum in the No‐change group, indicating familiarity with the spatial conditions. By contrast, the Prox‐Dist group displayed a significant increase in locomotion which was less robust in the Prox group and absent in the Dist group, a pattern suggesting that the pups relied more on proximal than distal cues during spatial exploration. c‐Fos activity in the No‐change group was significantly suppressed in the hippocampus (CA1, CA3, dentate gyrus) but simultaneously enhanced in the prelimbic area (PL) of the medial prefrontal cortex, compared with untreated Home‐cage controls, pointing to a possible involvement of the PL in regulating locomotion in familiar spaces. By contrast, in both Prox‐Dist and Prox groups c‐Fos activity was enhanced in hippocampal CA1 and CA3 regions, suggesting these regions might be particularly involved in regulating exploration of spatial novelty. Our findings show that functional representations of space at a systems level are formed already in pre‐weanling rats.
Effectiveness of mobile health‐based self‐management application for posttransplant cares: A systematic review
Authors: Abasi Sanaz , Yazdani Azita , Kiani Shamim , Mahmoudzadeh‐Sagheb Zahra 
Published: November 2021

AbstractBackground and aimsPatients after transplantation need medical management for the rest of their lives, and self‐management seems to lead to greater adherence to medical standards, improve early physical changes, and increase patient empowerment. The main objective of this article is to systematic review of the consideration to mobile health applications (m‐Health apps) used in transplantation.MethodsA systematic search was conducted MEDLINE (through PubMed), Web of Science, Scopus, and Science Direct from inception to November 2020. The Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) statement was used in this study. Comprehensive research was carried out using a combination of keywords and MeSH terms associated with m‐Health, empowerment, self‐management, and transplantation. Two independent reviewers screened titles and abstracts, assessed full‐text articles, and extracted data from articles that met inclusion criteria. Eligible studies were original research articles that included posttransplant care and mobile phone‐based applications to support self‐management and self‐care. Also, thesis, book chapters, letters to editors, short briefs, reports, technical reports, book reviews, systematic reviews, or meta‐analysis were excluded.ResultsWe divided all the reviewed articles into four categories, self‐management (medication adherence, adherence to medical regimen, and remote monitoring), evaluation, interaction, and interface; 37.5% of the studies were focused on lung transplantation. In 56.25% of the studies, medication adherence was considered because one of the main reasons for the rejection and graft loss is stated medication nonadherence. Also, 62.5% of the studies demonstrated that the use of m‐health improved medication adherence and self‐management in transplantation.ConclusionsThe use of m‐Health apps interventions to self‐management after transplantation has shown promising feasibility and acceptability, and there is modest evidence to support the efficacy of these interventions. We found that m‐Health solutions can help the patient in self‐management in many ways after transplantation.
Blood MALT1, Th1, and Th17 cells are dysregulated, inter‐correlated, and correlated with disease activity in rheumatoid arthritis patients; meanwhile, MALT1 decline during therapy relates to treatment outcome
Authors: Ye Zhuang , Chen Lu , Fang Ying , Zhao Ling 
Published: November 2021

AbstractObjectiveMucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) participates in inflammatory and autoimmune diseases via activating various signaling pathways and promoting the differentiation of T‐helper (Th) 1 and Th17 cells; however, it is rarely reported in rheumatoid arthritis (RA). This study aimed to assess the correlation of MALT1 with Th1 and Th17 cells and evaluate its potential as a biomarker for evaluating disease activity and treatment outcomes in RA patients.MethodsThis study enrolled 139 RA patients and 45 health controls (HCs); then, blood MALT1, Th1, and Th17 cells were determined. For RA patients only, blood MALT1 at week (W) 6 and W12 after treatment was also detected. Additionally, clinical response and remission of RA patients were assessed at W12.ResultsMALT1 (p < 0.001), Th1 (p = 0.011), and Th17 (p < 0.001) cells were all increased in RA patients than HCs; meanwhile, increased MALT1 was associated with elevated Th1 (p = 0.003) and Th17 (p < 0.001) cells in RA patients. Besides, MALT1, Th1, and Th17 cells were positively correlated with parts of disease activity indexes in RA patients (all p < 0.050). In addition, MALT1 was gradually declined from W0 to W12 (p < 0.001) in RA patients. Specifically, MALT1 at W6 and W12 was lower in response patients than no response patients (both p < 0.010), also in remission patients than no remission patients (both p < 0.050).ConclusionMALT1, Th1, and Th17 cells are dysregulated, inter‐correlated, and correlated with disease activity in RA patients; meanwhile, the decline of MALT1 expression can partly reflect RA treatment response and remission.
Usefulness of SARS‐CoV‐2 antigen test sample as input for SARS‐CoV‐2 RT‐PCR analysis
Authors: García‐Salguero Cristina , Culebras Esther , Merino Paloma , Baos Elvira , Delgado‐Iribarren Alberto 
Published: November 2021

AbstractSARS‐CoV‐2 rapid detection is of great interest to prevent viral dissemination. In that sense, antigen tests appeared as a very valuable tool to reach this goal. However, it is possible to obtain a negative result in those patients with low viral loads, and consequently, reverse transcription‐polymerase chain reaction (RT‐PCR) should be performed on samples from patients with a negative antigen test in which there is a strong suspicion of COVID infection. The common diagnostic algorithm involves taking a second sample for RT‐PCR testing. This study evaluates the usefulness of the antigen test sample for carrying out RT‐PCR analysis when necessary. Results obtained indicate that can be used a unique sample for both antigen test and RT‐PCR. This data showed that it is possible to reduce excessive suspected individuals managing and so on increase staff security and patient comfort.
Variants of concern responsible for SARS‐CoV‐2 vaccine breakthrough infections from India
Authors: Singh Urvashi B. , Rophina Mercy , Chaudhry Rama , Senthivel Vigneshwar , Bala Kiran , Bhoyar Rahul C. , Jolly Bani , Jamshed Nayer , Imran Mohamed , Gupta Ritu , Aggarwal Praveen , Divakar Mohit K. , Sinha Subrata , Arvinden V. R. , Bajaj Anjali , Shamnath Afra , Jain Abhinav ,   COVID CBNAAT CORE GROUP, Scaria Vinod , Sivasubbu Sridhar , Guleria Randeep 
Published: November 2021

AbstractEmerging reports of SARS‐CoV‐2 breakthrough infections entail methodical genomic surveillance for determining the efficacy of vaccines. This study elaborates genomic analysis of isolates from breakthrough infections following vaccination with AZD1222/Covishield and BBV152/Covaxin. Variants of concern B.1.617.2 and B.1.1.7 responsible for cases surge in April–May 2021 in Delhi, were the predominant lineages among breakthrough infections.
Elevated temperature relieves phosphorus limitation of marine unicellular diazotrophic cyanobacteria
Authors: Deng Lixia , Cheung Shunyan , Kang Chang‐Keun , Liu Kailin , Xia Xiaomin , Liu Hongbin 
Published: November 2021

AbstractThe warming ocean is expected to be more phosphorus (P) limited due to increasing stratification. P is a major limiting nutrient of marine diazotrophs, while the interactive effect of temperature elevation and P limitation on marine unicellular diazotrophs is unknown. Here, we examined the physiology of a major unicellular diazotroph, Crocosphaera watsonii, grown under P‐limited and P‐replete conditions at 25°C, 28°C, and 31°C. Growth, N2, and CO2 fixation rates of C. watsonii increased with temperature under P limitation, and growth rates were similar between P‐limited and P‐replete treatments at 31°C. At high temperature, the P use efficiencies for N2 and CO2 fixation under P limitation were more than twice higher than under P‐replete conditions. Expression of genes involved in P acquisition, intracellular recycling, and substitution in C. watsonii was upregulated at higher temperature under P limitation. These results suggest that P limitation in C. watsonii was relieved with elevated temperature through various temperature‐dependent economic strategies on P metabolism. Through meta‐analysis of a field data set using general additive model, we found that C. watsonii abundance was correlated mainly with temperature and phosphate, and predicted to increase significantly with further warming.
Retracted: Dissipative‐based synchronization of Markovian jumping complex dynamical networks with additive time‐varying delays, reaction‐diffusion terms, uncertainties, and sampled‐data control
Authors: Thakur Ganesh Kumar , Usha M. , Ali M. Syed , Priya Bandana , Kauser Syeda Asma 
Published: November 2021

Retraction: Thakur, GK, Usha, M, Ali, MS, Priya, B, Kauser, SA. Dissipative‐based synchronization of Markovian jumping complex dynamical networks with additive time‐varying delays, reaction‐diffusion terms, uncertainties, and sampled‐data control. Math Meth Appl Sci. 2021; 1‐20. doi:10.1002/mma.7880.The above article from Mathematical Methods in the Applied Sciences, published online on 16 November 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Wolfgang Sprößig, and John Wiley and Sons Ltd. The retraction has been agreed due to a compromised peer review process. The paper was accepted solely based on recommendations from reviewers with unambiguous conflicts of interest.
Low‐profile wideband dual‐polarized microstrip antenna element for 5G communication
Authors: An Wenxing , Wang Shuangshuang , Luo Yu 
Published: November 2021

AbstractA low‐profile wideband dual‐polarized microstrip antenna is presented for 5G communication. Using a periodical diamond structure, both low profile and wideband performance have been achieved with high port isolation. Relative bandwidths of 53.4% and 54.0% are obtained for two polarizations with a low profile of 0.047λ0, where λ0 is the free space wavelength at the center frequency of 4.18 GHz. The dual aperture coupling method is adopted for each polarization direction and high‐order modes are stimulated across the passband. The measured port isolation of more than 30 dB is obtained. Unidirectional radiation patterns have been achieved with low cross‐polarization levels. The proposed dual‐polarized microstrip antenna can offer a low‐profile structure and wideband performance, which can be another potential candidate for the 5G communication.
Bioarchaeological insights into disability: Skeletal dysplasia from the Iron Age northern China
Authors: Zhou Yawei , Lu Yiping , He Jianing , Li Ziyi , Zhang Xiangyu , Zhang Qun , Yeh Hui‐yuan 
Published: November 2021

AbstractSkeletal dysplasia is mainly caused by genetic mutations or endocrine abnormality. In this study, a case of disproportionate dwarfism from the Iron Age Beishenjiaqiao cemetery in Xi'an, China is analyzed from the perspective of bioarchaeology. The individual shows disproportionately short stature, with reduced long‐bone diaphyseal length especially of both humeri, unfused proximal humerus epiphyses, abnormal development of the shoulder and hip joints, left femoral head necrosis, and unusually gracile left femur and tibia shaft, demonstrating limited mobility and labor capacity. Hypothyroidism, pseudoachondroplasia, and multiple epiphyseal dysplasia are the most likely possible diagnoses although there are other possibilities. By combining the archaeological evidences and historical records, it is speculated that this individual lived a normal life and was well treated during her lifetime. Overall, this rare case concerning dwarfism not only enriches our knowledge of skeletal dysplasia among ancient Chinese in northern China but also demonstrates the humanitarian attitude of ancient society toward the disability.
EU microbial pest control: A revolution in waiting
Authors: Helepciuc Florența‐Elena , Todor Arpad 
Published: November 2021

AbstractRecent evaluations of the microbial biological control sector indicate that implementing microbial control of pests is still slow in the EU. The top causal factors are the lengthy, expensive, and cumbersome two‐stage procedure for approval of biological agents as active substances at the EU level and authorization of formulated products at the national level, limited funding, lack of EU level integrated approaches, and slow implementation of integrated pest management. This article contributes to a better understanding of the factors that limit microbial control of pests in EU agriculture by providing the first evaluation of the evolution of microbial biological control agent (MBCA) EU‐level approval combined with that of microbial biological control product (MBCP) national‐level authorization, discusses recent trends in research and offers some policy recommendations. By 2020, the EU had caught up with the USA regarding research output, approved MBCAs, and MBCA approval procedures (first stage). Despite improvements from 2014 to 2019, the number of authorized MBCPs (second stage) has progressed slowly and unevenly across the EU. Significant progress is concentrated in countries with more extensive agricultural land and higher research intensity. The EUʼs focus on promoting more sustainable agriculture by increasing the availability of low‐risk pesticides of biological origin as alternatives to conventional chemical pesticides has gained traction in recent years. Nevertheless, more efforts to improve the capacity and expertise of laggard EU Member States to contribute to the approval of MBCA, authorization of MBCP, and stimulating market availability are needed. Furthermore, we recommend introducing more concrete measures to promote the adoption of the microbial control of pests in the National Action Plans for the sustainable use of pesticides. © 2021 Society of Chemical Industry.
Influence of sample volume on nitrate N and O isotope ratio analyses with the denitrifier method
Authors: Zhou Mengyang , Granger Julie , Chang Bonnie X. 
Published: November 2021

RationaleAnalyses of the isotope ratios of nitrogen (15N/14N) and oxygen (18O/16O) in nitrate (NO3−) with the denitrifier method require relatively high sample volumes at low concentrations (≤1 μM) to afford sufficient analyte for mass spectrometry, resulting in isotopic offsets compared to more concentrated samples of the same isotopic composition.MethodsTo uncover the origins of isotopic offsets, we analyzed the N and O isotope ratios of NO3− reference materials spanning concentrations of 0.5–20 μM. We substantiated the incidence of volume‐dependent isotopic offsets, then investigated whether they resulted from (a) incomplete sample recovery during N2O sparging, (b) blanks – bacterial, atmospheric, or in reference material solutions – and (c) oxygen atom exchange with water during the bacterial conversion of NO3− to N2O.ResultsLarger sample volumes resulted in modest offsets in δ15N, but substantial offsets in δ18O. N2O recovery from sparging was less complete at higher volumes, resulting in decreases in δ15N and δ18O due to associated isotope fractionation. Blanks increased detectably with volume, whereas oxygen atom exchange with water remained constant within batch analyses, being sensitive to neither sample volume nor salinity. The sizeable offsets in δ18O with volume are only partially explained by the factors considered in our analysis.ConclusionsOur observations argue for bracketing of NO3− samples with reference materials that emulate sample volumes (concentrations) to achieve improved measurement accuracy and foster inter‐comparability.
Development of a mobile robot for safe mechanical evacuation of hazardous bulk materials in industrial confined spaces
Authors: Shafaei Seyed Mojtaba , Mousazadeh Hossein 
Published: November 2021

AbstractSafe mechanical evacuation of hazardous bulk materials in industrial confined spaces with improper conditions (poor light for vision, dust or vapor, high temperature, and toxic fume) and potential of combustion and explosion is high‐risk mission for human. This study deals with development and performance assessments of a robot for this purpose. The robot comprised four major units including control, electro‐hydraulic actuator, communication, and monitoring unit. Detailed descriptions of the units and their main components are beyond the scope of current report. Meanwhile, the robot has movable and stationary parts. The movable part is a wheeled mobile robot which guides suction tube in the confined space. Robotic evacuation operations are accomplished by supervisory remote control at base station with feedback from camera video of the mobile robot. Simulation results showed accurate performance of defined objectives for the units and their main components through designed hydraulic and electronic circuits. Stationary assessments for forward speed (0–30 m/min) and drawbar pull (‐0‐755.6 N) of the mobile robot yielded acceptable results in case of robot mobility. Operational assessments of the robot in two chemical reactors comprised depreciated catalyst and ceramic balls practically approved efficient, safe, feasible, and easily implementable of robotic evacuation operations. Overall, the robot proposed in this study eliminates employment of a human in highly risky conditions of industrial confined spaces.
Highly Reliable Implementation of Optimized Multicomponent Oxide Systems Enabled by Machine Learning‐Based Synthetic Protocol
Authors: Park Boyeon , Kim Minho , Kang Youngjin , Park Hun‐Bum , Kim Myung‐Gil , Park Sung Kyu , Kim Yong‐Hoon 
Published: November 2021

AbstractMulticomponent oxide systems are one of the essential building blocks in a broad range of electronic devices. However, due to the complex physical correlation between the cation components and their relations with the system, finding an optimal combination for desired physical and/or chemical properties requires an exhaustive experimental procedure. Here, a machine learning (ML)‐based synthetic approach is proposed to explore the optimal combination conditions in a ternary cationic compound indium‐zinc‐tin oxide (IZTO) semiconductor exhibiting high carrier mobility. In particular, by using support vector regression algorithm with radial basis function kernel, highly accurate mobility prediction can be achieved for multicomponent IZTO semiconductor with a sufficiently small number of train datasets (15–20 data points). With a synergetic combination of solution‐based synthetic route for IZTO fabrication enabling a facile control of the composition ratio and tailored ML process for multicomponent system, the prediction of high‐performance IZTO thin‐film transistors is possible with expected field‐effect mobility as high as 13.06 cm2 V−1 s−1 at the In:Zn:Sn ratio of 63:27:10. The ML prediction is successfully translated into the empirical analysis with high accuracy, validating the protocol is reliable and a promising approach to accelerate the optimization process for multicomponent oxide systems.
Brane current algebras and generalised geometry from QP manifolds. Or, “when they go high, we go low”
Authors: Arvanitakis Alex S. 
Published: November 2021

Abstract
We construct a Poisson algebra of brane currents from a QP-manifold, and show their Poisson brackets take a universal geometric form. This generalises a result of Alekseev and Strobl on string currents and generalised geometry to include branes with worldvolume gauge fields, such as the D3 and M5. Our result yields a universal expression for the ’t Hooft anomaly that afflicts isometries in the presence of fluxes. We determine the current algebra in terms of (exceptional) generalised geometry, and show that the tensor hierarchy gives rise to a brane current hierarchy. Exceptional complex structures produce pairs of anomaly-free current subalgebras on the M5-brane worldvolume.
Twistor constructions for higher-spin extensions of (self-dual) Yang-Mills
Authors: Tran Tung 
Published: November 2021

Abstract
We present the inverse Penrose transform (the map from spacetime to twistor space) for self-dual Yang-Mills (SDYM) and its higher-spin extensions on a flat background. The twistor action for the higher-spin extension of SDYM (HS-SDYM) is of $$ \mathcal{BF} $$
BF
-type. By considering a deformation away from the self-dual sector of HS-SDYM, we discover a new action that describes a higher-spin extension of Yang-Mills theory (HS-YM). The twistor action for HS-YM is a straightforward generalization of the Yang-Mills one.
Safety of intermittent Pringle maneuver during minimally invasive liver resection in patients with hepatocellular carcinoma with and without cirrhosis
Authors: Ortiz Galindo Santiago A. , Haber Philipp K. , Benzing Christian , Krenzien Felix , Riddermann Anna , Frisch Oliver , Schöning Wenzel , Schmelzle Moritz , Pratschke Johann , Feldbrügge Linda 
Published: November 2021

Abstract

Purpose
The aim of this study was to analyze the impact of minimally invasive intermittent Pringle maneuver (IPM) on postoperative outcomes in patients with hepatocellular carcinoma (HCC) and liver cirrhosis.

Methods
In this retrospective cohort study, we evaluated the safety of IPM in patients with HCC who underwent minimally invasive liver resection during five years at our center. Factors influencing the use of IPM were examined in univariate and multivariate regression analysis. Cases with use of IPM (IPM) and those without use of IPM (no IPM) were then compared regarding intraoperative and postoperative outcomes after propensity score matching (PSM) for surgical difficulty.

Results
One hundred fifty-one patients underwent liver resection for HCC at our center and met inclusion criteria. Of these, 73 patients (48%) received IPM with a median duration of 18 min (5–78). One hundred patients (66%) had confirmed liver cirrhosis. In multivariate analysis, patients with large tumors (≥ 3 cm) and difficult tumor locations (segments VII or VIII) were more likely to undergo IPM (OR 1.176, p = 0.043, and OR 3.243, p = 0.001, respectively). After PSM, there were no differences in intraoperative blood transfusion or postoperative complication rates between the IPM and no IPM groups. Neither did we observe any differences in the subgroup analysis for cirrhotic patients. Postoperative serum liver function tests were not affected by the use of IPM.

Conclusions
Based on our findings, we conclude that the use of IPM in minimally invasive liver resection is safe and feasible for patients with HCC, including those with compensated liver cirrhosis.