bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natas,Nitis, Netes:Vaccine being Supermoom
Authors: Purwandary Eny , Kusumadewi Icha 
Published: January 2021

<p class="06IsiAbstrak">The purpose of this research was to see the effectiveness of the method of natas, nitis, netes as a vaccine to be supermoom in inclusive school children in Surakarta. This study used an experimental design with a randomized matched two group design posttest only. Data collected by dividing two groups, namely the control group and the group that was given treatment with 50 participants each. Participants in this study were mothers who had children attending inclusive elementary schools with specific learning difficulties. The results of this study were the methods of natas, nitis, and netes were effective as vaccines to become supermoom.</p>
Effect of a Novel Stretching Technique on Shoulder Range of Motion in Overhead Athletes with Glenohumeral Internal Rotation Deficits: A Randomized Controlled Trial
Authors: Gharisia Omar , Lohman Everett , Daher Noha , Eldridge Alan , Shallan Amjad , Jaber Hatem 
Published: January 2021

Abstract
Background: The cross-body and the modified sleeper stretch have been used to improve posterior shoulder soft tissue flexibility and to increase glenohumeral joint internal rotation (GHJ IR) in overhead athletes. However, due to the inability to stabilize patient’s scapula and control GHJ rotation with the cross-body stretch and the potential for subacromial impingement or symptoms’ aggravation with the modified sleeper stretch, a new stretching technique (Passive Glenohumeral Internal Rotation with Clam Shell Bridging) was developed as an alternative to these commonly used stretches that may allow for greater stability of the scapula without reproducing symptoms, as well as providing an inhibition component to the posterior shoulder girdle muscles. Thus, the current study aimed to examine and compare a novel stretching technique to the traditional modified sleeper stretch to determine the effect on glenohumeral IR range of motion (ROM) and self-reported pain in overhead athletes with glenohumeral internal rotation deficits (GIRD). Methods: Forty-two overhead athletes with GIRD [mean age 25.9 ± 2.6 years, 20 males and 22 females] participated in this study. Participants were randomly assigned into either novel stretching group or modified sleeper stretching group. IR ROM was measured with a digital inclinometer before, immediately, and at week 4 post intervention, while pain was measured with Numeric Pain Rating Scale before and at week 4 post intervention.Results: There was no significant group by time interaction effect for IR ROM (p=0.27); however, there was a significant change over time (p<0.001, η2=0.77). Both groups demonstrated a significant increase in IR from baseline to immediate and week 4, and from immediate to week 4 (p<0.001). There was a significant group by time interaction for pain intensity (p=0.032, η2=0.31). Results showed a significant reduction in pain intensity over time in the novel group (p=0.001, η2=0.85), but not in the traditional group (p=0.150, η2=0.27).Conclusion: Both stretches appear to be effective at improving IR ROM in overhead athletes with GIRD. However, the novel stretching might be more effective at reducing shoulder pain and thus may be more appropriate for symptomatic patients. Trial registration: Prospectively registered in February 6, 2017 under Clinical Trial Registry # NCT03044236
Secondary endpoints analysis in patients with estrogen receptor-positive metastatic breast cancer treated with everolimus and exemestane enrolled in Oral Care-BC
Authors: Nakatsukasa Katsuhiko , Niikura Naoki , Kashiwabara Kosuke , Amemiya Takeshi , Watanabe Kenichi , Hata Hironobu , Kikawa Yuichiro , Taniike Naoki , Yamanaka Takashi , Mitsunaga Sachiyo , Nakagami Kazuhiko , Adachi Moriyasu , Kondo Naoto , Shibuya Yasuyuki , Hayashi Naoki , Naito Mariko , Yamashita Toshinari , Umeda Masahiro , Mukai Hirofumi , Ota Yoshihide 
Published: January 2021

Abstract
Background: The Oral Care BC-trial reported that professional oral care (POC) reduces the incidence and severity of oral mucositis in patients receiving everolimus (EVE) and exemestane (EXE). However, the effect of POC on clinical response among patients receiving EVE and EXE was not established. We compared outcomes for estrogen receptor-positive metastatic breast cancer patients who received POC to those who had not, and evaluated clinical prognostic factors. All patients simultaneously received EVE and EXE. Methods: Between May 2015 and Dec 2017, 174 eligible patients were enrolled in the Oral Care-BC trial. The primary endpoint was the comparative incidence of grade 1 or worse oral mucositis, as evaluated for both the groups over 8 weeks by an oncologist. The secondary endpoints were progression-free survival (PFS) and overall survival (OS). Data were collected after a follow-up period of 13.9 months. Results: There were no significant differences in PFS between the POC and Control Groups (P = 0.801). A BMI < 25 mg/m2 and non-visceral metastasis were associated with longer PFS (P = 0.018 and P = 0.003, respectively) and the use of bone modifying agents (BMA) was associated with shorter PFS (P = 0.028). The PFS and OS between the POC and control groups were not significantly different in the Oral-Care BC trial. Conclusions: POC did not influence the prognosis of estrogen receptor-positive metastatic breast cancer patients. Patients with non-visceral metastasis, a BMI < 25 mg/m2, and who did not receive BMA while receiving EVE and EXE may have better prognoses.Trial registration: The study protocol was registered online at the University Hospital Medical Information Network (UMIN), Japan (protocol ID 000016109), on January 5, 2015 and at ClinicalTrials.gov (NCT02376985).
Clinical Utility of the BIWACO&nbsp;Score for Patients With Atrial Fibrillation After Percutaneous Coronary Intervention
Authors: Takeda Teruki , Dohke Tomohiro , Ueno Yoshiki , Mastui Toshiki , Fujii Masanori , Takayama Tomoyuki , Dohchi Kenichi , Miyamoto Akashi , Mabuchi Hiroshi , Wada Atsuyuki 
Published: January 2021

Abstract
Background: No predictive clinical risk scores for net adverse clinical events (NACE) have been developed in patients with atrial fibrillation (AF) after percutaneous coronary intervention (PCI). Methods: We evaluated the NACE in order to develop clinically applicable risk-stratification scores in the BIWACO study, a multicenter survey which enrolled a total of 7837 patients. We also investigated the current status and time trends for the use of antithrombotic drugs.Results: A total of 188 AF patients who had received PCI were enrolled. At discharge, 65% of patients were prescribed a triple therapy (TT), 6% were prescribed a dual therapy, the remaining 29% of patients received dual-antiplatelet therapy. Over 3 years, the fraction of patients continuing TT decreased by 15%, whereas only 2% received oral anticoagulant alone. NACE developed in 20% of patients, resulting in the deaths of 5% patients, and 13% experiencing bleeding events. We developed risk scores for NACE comprising the five best predictive items, which we designated BIWACO scores. The area under the curve was 0.774 for NACE. Conclusions: Our study explored the differences in treatment practices and guideline recommendations for antithrombotic therapy. We concluded that our BIWACO score is useful for predicting clinical outcomes in AF-patients after PCI.
Exploratory Analysis of COVID-19 Patients Usingprincipal Component Analysis, Feature Selection and Predictive Algorithms
Authors: Carlotti Danilo , Buss Lewis , Leite Gabriel , Levin Anna , Sabino Ester , Nunes Fátima , Ferreira João 
Published: January 2021

Abstract
A. BackgroundThe novel coronavirus disease (COVID-19) emerged in late 2019 has shown that research done with open data could be the cornerstone for overcoming the need for collaborative, optimized and urgent analysis. Although several articles have been published, identiﬁcation of variables that can have correlation with positive PCR results is still a challenge. In this paper we show a concrete example of open data analysis from 910 patients attended in the hospital undergoing SARS-CoV-2 RT-PCR in three private institutions in S˜ao Paulo, Brazil.B. ResultsWe performed an exploratory analysis using principal component analysis, feature selection and predictive algorithms to test for associations between a number of laboratory test abnormalities and the SARS-CoV-2 RT-PCR result. More concretely, we found a set of 18 variables that showed some association with a positive PCR result.C. ConclusionAmong these variables elevated lactic dehydrogenase (LDH) and d-dimer were the most correlated with a positive RT-PCR. We developed a classiﬁer that achieved 76% mean accuracy, 77% mean precision and 92% mean sensitivity to identify individuals with COVID-19.
Tumor MHCII immunity requires in situ antigen presentation by cancer-associated fibroblasts.
Authors: Kerdidani Dimitra , Aerakis Emmanouil , Verrou Kleio , Stamoulis Petros , Goudevenou Katerina , Prados Alejandro , Tzaferis Christos , Vamvakaris Ioannis , Kaniaris Evangelos , Vachlas Konstantinos , Sepsas Evangelos , Potaris Konstantinos , Koutsopoulos Anastasios , Tsoumakidou Maria 
Published: January 2021

Abstract
A key unknown of the functional space in tumor immunity is whether physiologically relevant cancer antigen presentation occurs solely in draining lymph nodes versus tumors. Professional antigen presenting cells, i.e. the dendritic cells, are scarce and immature within tumors, greatly outnumbered by MHCII expressing non-hematopoietic cells, such as antigen-presenting cancer-associated fibroblasts (apCAFs). We hypothesized that after their exit from tumor-draining lymph nodes T cells depend on a second wave of antigen presentation provided in situ by structural cells. We show that dense apCAF regions in human lung tumors define hot immunological spots with increased numbers of CD4 T cells. The transcriptomic profile of human lung apCAFs aligned to that of pancreatic apCAFs across mice and humans and were both enriched for alveolar type II genes, suggesting an epithelial origin. Mechanistically, human apCAFs directly activated the TCRs of adjacent effector CD4 T cells and at the same time produced high levels of c1q, which acted on surface c1qbp on T cells to rescue them from apoptosis. Fibroblast-specific deletion of MHCII in mice impaired local MHCII immunity and accelerated tumor growth, while inducing c1qbp overexpression in adoptively transferred T cells expanded their numbers within tumors and reduced tumour burden. Collectively, our work shows that tumor T cell immunity post lymph node exit requires peripheral antigen presentation by a subset of CAFs and proposes a new conceptual framework upon which effective cancer immunotherapies can be built.
Rehospitalisation Risk Factors and Rates in Preterm Babies: A Systematic Review and Meta-Analysis
Authors: Reed Robert , Morgan Andrei , Zeitlin Jennifer , Dechartres Agnès , Ancel Pierre-Yves , Khoshnood Babak 
Published: January 2021

Abstract
Objective: To systematically review evidence of risk factors and rates for rehospitalisations within one month of discharge for babies born at <37 weeks gestation.Design: Systematic review and meta-analysisData Sources: PubMed (including MEDLINE and life science journals), Web of Science and reference lists of included articles. Study Selection: Inclusion criteria were studies published in English or French between 01 January 2000 to 31 March 2019, recruiting from the year 2000 onwards evaluating risk factors for rehospitalisation within one month of discharge in preterm babies. Two reviewers independently selected relevant studies, extracted study details, baseline characteristics and results of risk factor analyses. Results: Across 14 included studies, five studied babies of <37 weeks gestation, seven studied late preterm babies (34-36 weeks gestation), and two studied very to moderate preterm babies (<34 weeks gestation). Important risk factors were low birth weight, respiratory morbidity, male sex and lower socioeconomic status in <37 week babies, and shorter length of stay among late preterm babies. Pooled rehospitalisation rates were 4.3% (95% CI 1.9-9.7) in <37 week babies and 6.6% (95% CI 3.2-13.4) in late preterm babies. There was high heterogeneity in risk factors included in analyses and studies often lacked clarity on variable measurement and confounder adjustment.Conclusion: We found evidence for clinical and socioeconomic risk factors, high heterogeneity and important limitations. Limitations included a lack of breadth in both the gestational age ranges and risk factors studied, as well as lack of clarity around variable measurement and confounder adjustment
Designated Server-Aided Revocable Identity-based Keyword Search on Lattice
Authors: Guo Ying , Meng Fei , Cheng Leixiao , Dong Xiaolei , Cao Zhenfu 
Published: January 2021

Abstract
Public key encryption scheme with keyword search (PEKS) is a promising technique supporting search on encrypted data without leaking any information about the keyword. In real applications, it's critical to find an effective revocation method to revoke users in multi-user cryptosystems, when user's secret keys are exposed.In this paper, we propose the first designated server-aided revocable identity-based encryption scheme with keyword search (dSR-IBKS) from lattice. The dSR-IBKS model requires each user to keep just one private key corresponding with his identity and does not need to communicate with the key generation center or the server during key updating. We have proved that our scheme can achieve chosen keyword indistinguishability in the standard model. In particular, our scheme can designate a unique tester to test and return the search results, therefore no other entity can guess the keyword embedded in the ciphertext by generating search queries and doing the test by itself. We provide a formal security proof of our scheme assuming the hardness of the learning with errors (LWE) problem on the standard model.
CSF PGRN May be Associated With Postoperative Delirium After Knee Replacement in Elderly Patients: The PNDABLE Study
Authors: Wang Bin , Sun Jie Xiu , Tao He , Deng Yuan Xi , Lin Nan Ya , Liu Hao fang , Lin Xu , Dong Rui , Liu Qiu Yu , Bi Yanlin 
Published: January 2021

Abstract
BackgroundPostoperative delirium (POD) represents a serious complication following anesthesia and surgical procedures for patients undergoing surgical intervention (1). Little is known about the mechanisms underlying similarities in the core features between postoperative delirium (POD) and progranulin (PGRN)-related cognitive disorders. We herein investigated the relationship between preoperative CSF PGRN concentration and POD occurrence in the Han Chinese patients undergoing unilateral total knee arthroplasty.MethodsWe conducted an observational, prospective, and 1:1 matched (on age older than 65, the unilateral total knee arthroplasty, American Society of Anesthesiologist’ (ASA) physical status, duration of surgery, and intraoperative bleeding) case-control study. POD cases and non-POD controls were selected from the overall cohort using Confusion Assessment Method (CAM). Delirium severity was measured by the Memorial Delirium Assessment Scale (MDAS). CSF PGRN and core biomarkers were measured by ELISA using the microplate reader. The associations of CSF PGRN levels with POD risk and CSF core biomarkers were assessed.ResultsPOD incidence was 9.7% (53/545). There were significant differences in preoperative CSF PGRN concentration between POD patients and controls (P<0.001), and CSF PGRN levels increased with age, as demonstrated by a significantly positive correlation (r=0.796, P<0.001).CSF PGRN levels to increase with CAM scores and MDAS scores, as demonstrated by significantly positive correlations (r=0.693, P<0.001; r=0.590, P<0.001). There were positive associations of CSF PGRN with T-tau (β = -0.501, P < 0.001) and P-tau (β = -0.470, P < 0.001) and negative associations of CSF PGRN with Aβ1–42 (β = -0.576, P < 0.001), Aβ1–40 (β = -0.488, P < 0.001), Aβ42/p-tau (β = -0.422, P < 0.001), and Aβ42 / T- tau (β = -0.395, P < 0.001) in POD patients. The ROC curve analysis of PGRN showed that PGRN concentrations had high diagnostic value for POD.ConclusionsCSF PGRN may be associated with the POD. Aβ pathology is associated with a decrease in CSF PGRN in the absence of tau deposition and neurodegeneration, whereas tau pathology and neurodegeneration is associated with an increase in CSF PGRN.Clinical Trial Registrationwww.clinicaltrials.gov, identifier ChiCTR2000033439.
Chromosome Analysis and Postnatal Follow-Up of Fetuses With Abnormal Ultrasound Findings
Authors: Pan Lijuan , shi Meizhen , dai Lei , chen Kuifang , Cao chuanding , Zhang Zhenhui 
Published: January 2021

Abstract
Objective—To analyze the correlation between copy number variations (CNVs) and prenatal ultrasound abnormalities, characterize the CNVs in diverse prenatal phenotypes, and provide detailed follow-up results for prenatal diagnosis. Method—The results obtained in 1152 fetuses referred for chromosome testing due to different ultrasound anomalies were analyzed. CNV detection was performed by chromosomal microarray analysis (CMA) and copy number variation sequencing (CNV-seq). The postnatal outcomes of the fetuses were followed up.Result—Chromosomal abnormalities were detected in 149 of 1152 pregnancies (12.9%), including 84 (7.3%) macroscopic and 65 (5.6%) submicroscopic anomalies. The highest proportion of chromosomal defects was found in fetuses with hydrops (38.5%), followed by fetuses with multiple abnormalities (32.1%). The most common CNV number variation was 22q11 deletion (0.7%), followed by 17q12 deletion (0.4%) and 15q11.2 deletion (0.4%). Bilateral hyperechogenic kidneys were identified in all fetuses with the 17q12 deletion, and all cases of 15q11.2 deletion were positive only for soft markers. On postnatal follow-up of 362 live births, 2 cases of esophageal atresia and 2 cases of craniosynostosis were found that were not accurately diagnosed by prenatal ultrasound.Conclusion—we identified chromosomal abnormalities in approximately one eight of the pregnancies with abnormal ultrasound findings. More emphasis should be placed on the improvement of prenatal detection of esophageal atresia and craniosynostosis.
Prediction of Gas Pressure in Thin Coal Seams in the Qinglong Coal Mine in Guizhou Province, China
Authors: Zhang Jian , Zhang Yongqiang , Wang Jilin , Wen Xiaobin 
Published: January 2021

Abstract
Thin coal seams in mines lack gas data; thus, gas outbursts of thin coal seams are difficult to prevent and control. In this study, a coal structure index, which is used to express the damage degree of coal, was estimated by logging curve. In accordance with the contour line of the floor of the coal seam, structural curvature was calculated to quantitatively express the complexity of the coal seam structure. Then, the relationships among the burial depth, thickness, coal structure index, structural curvature, with gas pressure of coal seam were analyzed. The gas pressure of coal seam of Nos. 22, 24, and 27 in the study area was predicted by multiple linear regression (MLR) and then was verified and analyzed. The deviation rate of the MLR method was 6.5%–19.7%, with an average of 13.0%. The average deviation rate between the predicted value and the measured value was 11.6%, except for measuring point of No. 2, which had a large deviation. Results show that the prediction accuracy of the above method is acceptable, and it has practical value in the prediction of gas pressure in thin coal seams without measured data. Results of the gas pressure prediction provide a basis for evaluating the risk of gas outbursts in thin coal seams.
The Gender-Specific Effect of Subcutaneous and Visceral Adipose Tissues on Cardiometabolic Risk in a Chinese Population
Authors: Wu Qiong , Chen Qiannan , Lv Qingguo , Xiaohui Sun , Dai Chen , Zhang Xuhui , Zhou Jiaqiang , Zhu Yimin 
Published: January 2021

Abstract
BackgroundPrevious studies demonstrated that visceral adipose tissue (VAT) contributed to increased risks for multiple cardiometabolic factors. However, the effects of subcutaneous adipose tissue (SAT) were controversial. Furthermore, their effects were varied across sexes. The aim of this study was to examine the gender-specific effects of VAT, SAT, and VAT/SAT ratio on cardiometabolic risk factors. Methods1388 eligible subjects were recruited from a metabolic syndrome cross-sectional study in China. Areas of abdominal VAT and SAT were determined by nuclear magnetic resonance imaging (MRI). Multiple logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (95%CI). ResultsSAT, VAT, and VAT/SAT ratio had significant age-adjusted, positive correlations with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), total triglycerides (TG), and inverse correlations with high-density lipoprotein cholesterol (HDL-C) except VAT/SAT ratio with FPG in men. After additional controlled by BMI, consistent results were found in VAT and VAT/SAT ratio except for VAT with FPG, however, women showed significant inverse correlations between SAT and SBP, DBP and TG. Higher SAT exhibited a significantly reduced risk for type 2 diabetes (T2D) in women, the ORs in third quartile (Q3) and fourth quartile (Q4) group were 0.3 (95% CI: 0.13-0.74) and 0.19 (95% CI: 0.07-0.54). Men had higher ORs of VAT, VAT/SAT ratio than women in higher TG, low HDL-C, and hypertension while the ORs of VAT/SAT ratio in men were lower than women in T2D. Conclusions SAT exhibited a beneficial effect on T2D. VAT and VAT/SAT ratio linked increased risks for high TG, low HDL-C, and hypertension, with men had a more pronounced effect than women. Distribution of abdominal fat associates with its biological effects.
Skeletal Muscle Mass Is Associated With Erythropoietin Response in Hemodialysis Patients
Authors: Takata Tomoaki , Mae Yukari , Yamada Kentaro , Taniguchi Sosuke , Hamada Shintaro , Yamamoto Marie , Iyama Takuji , Isomoto Hajime 
Published: January 2021

Abstract
Background: Hyporesponsiveness to erythropoietin stimulating agent (ESA) is associated with poor outcome in patients with chronic kidney disease. Although ESA hyporesponsiveness and sarcopenia have common pathophysiological background, clinical evidence linking them are scarce. The purpose of the study was to investigate the relationship between ESA responsiveness and skeletal muscle mass in hemodialysis patient. Methods: This cross-sectional study analyzed 70 patients on maintenance hemodialysis who were treated with ESA. ESA responsiveness was evaluated by erythropoietin resistance index (ERI), calculated as weekly dose of ESA divided by body weight and hemoglobin (IU/kg/week/dL), and weekly dose of ESA/hemoglobin (IU/week/dL). Dose of ESA was equivalated with epoetin β. Correlations between ESA responsiveness and clinical parameters including skeletal muscle mass were analyzed. Results: Among the 70 patients, ERI was positively correlated to age (p < 0.002), whereas negatively correlated to height (p < 0.001), body weight (p < 0.001), BMI (p < 0.001), skeletal muscle mass (p < 0.001), transferrin saturation (TSAT) (p = 0.049), and zinc (p = 0.006). In the multiple linear regression analysis, TSAT, zinc and skeletal muscle mass were associated with ERI and weekly ESA dose/hemoglobin. Conclusions: Skeletal muscle mass was the independent predictor for ESA responsiveness as well as TSAT and zinc. Sarcopenia is another target for the management of anemia in patients with hemodialysis.