bluuebunny/crossref_metadata_2025_split huggingface dataset:
Après-coup e avant-coup: la morte e la scena primaria
Authors: Parsons Michael 
Published: June 2021

- Being fully and creatively alive depends on giving meaning to present experience in the light of the past (Winicott's "creative apperception") and at the same time rearticulating the past in the light of subsequent experience (après-coup). This freedom of psychic movement up and down a life should leave the present moment always open to the unheimlich. The same process needs also to extend into the future. A gaze forward from the present, and an imaginative gaze backward to it from the future, are the equivalent, with time's arrow reversed, of creative apperception and après-coup in relation to the past. The Author proposes the name of dynamic avant-coup, or Vorträglichkeit for this capacity to keep reconfiguring in fresh ways one's availability to the future, The present moment is created by the encounter between après-coup and avant-coup and is a point of intersection between time and timelessness. It punctuates an expanse boundaried by the primal scene and death. These two are always present, at some level, in the analytic encounter. A clinical example illustrates the presence of these themes beneath the conscious surface of the analytic work.Parole chiave: Vitalità, après-coup, compiacenza, appercezione creativa, morte, memoria, scena primaria, perturbanteKey words: Aliveness, après-coup, compliance, creative apperception, death, memory, primal scene, uncanny
Considerazioni sul timing. L'approfondimento di un concetto effettuato su materiale clinico con l'uso della"griglia di riferimento"
Authors: Lucantoni Cinzia , Mariotti Paolo , Pierini Rita 
Published: June 2021

- The authors aim to deepen the concept of timing. They focus on the internal and external facts used by the analysts in the choice of when to interpret. Following an accurate historical examination of the concept of timing, some detailed clinical material is presented. A specific greed is articulated as an instrument used to deepen those aspects that have an influence on the analyst's choice of the timing of interpretation. Evidence shows that countertransference factors are determinant in the choice of the timing thus giving shape to unconscious resistances that delay interpreting. The Authors show how the capacity to work through and self analysis allow instead to maintain the awareness of the ongoing psychoanalytic processParole chiave: timing, alleanza terapeutica, role responsiveness, griglia, teorie implicite, controtransfertKey words: timing, therapeutic alliance, role responsiveness, grid, implicit theories, countertransference
حقِّ الزوجة في مال الزوج المكتسب بعد الزواج - دراسة فقهية
Authors: Abdelgayed Ahmed Fathi Ramadan 
Published: June 2021

At present, there have been some calls for the wife to share the property acquired by the husband during the marriage period, claiming that these efforts are the result of the effort of both spouses, whether through the woman's work in the home, where that husband helped to work quietly outside the home, or through the couple's work outside the home. In this research, I discussed the evidence of the wife's participation in all the property acquired by the husband.
In this research, it concluded that the spouses in matters of property, wealth, income and conduct are completely independent, that the marriage contract does not give rise to any right to the other's property or income other than Islamic rights,
The financial dealings between spouses were governed by the Islamic provisions on financial transactions, and if the spouses disagreed in the ownership of something, each one must provide evidence of the validity of his claim.
التكييف الفقهي للأموال المشتركة بين الزوجين في ضوء الأدلة الاجتهادية
Authors: Muhamad Etrebi Muhamad Fathye , Suleiman Hassan 
Published: June 2021

Al-ʿUrf (customary law) is considered among the disputed jurisprudential evidence between the Uṣulī scholar. However, it is not hidden from majority of the scholar that custom has legal impact and that custom is authoritative, besides, it is well-known that custom is one of the major legal maxims according to the Shafiʿīs, and there is no doubt that resorting to custom is based on the realization of public interests and sometimes of a class or sect of society, given its legislative framework and its significant divisions among the fundamentalists.Therefore, under the light of jurisprudential evidence, this research aims for a sound jurisprudential computation of the shared properties between the spouses by examining the term and defining its concept, and does one of the spouse has the right to demand some money when the marriage discontinues, or is it permissible to request in the event of a divorce or death between them with something from the husband’s private gain as a partner in it? If the Sharīʿah does not allow the will in a person’s life by more than a third, which is his money and his dependents’, does it is permissible for the spouse to demand half of the properties upon divorce or death, while half is more than one-third, and for what extend will the damage or loss occur in the half division? By that, this research has followed the descriptive inductive analytical approach to arrive into its findings.
Bioefficacy of Three Indigenous Plant Extracts Against Callosobruchus Chinensis L. (BRUCHIDAE: COLEOPTERA)
Authors: Ahmed SMS , Hossain MA , Siddique AB , Bachchu MAA 
Published: June 2021

Results of the evaluation on bioefficacy of three indigenous plant extracts for toxicity and residual effects against the pulse beetle, Callosobruchus chinensis L. (Bruchidae: Coleoptera) showed that the plant extracts had toxic and residual effects for controlling pulse beetle. Mortality and residual effects were statistically different among the plant extracts and doses applied. Neem extract showed the highest adult mortality (36.78%) whereas eucalyptus extract showed the lowest (22.75%). The order of the toxicity of three plant extracts was found as neem > custard apple > eucalyptus. Mortality was found directly proportional to the hour after treatments which increased with the progress of time. Between two solvents, acetone solvent possessed the highest toxicity (mortality 32.95%) but methanol showed the lowest toxicity (mortality 30.56%). The residual toxicity was evaluated on the basis of egg laid, adult emergence, seed infestation and weight loss caused by the insect. The highest residual toxicity was found in neem extract with acetone while the lowest in eucalyptus extract with acetone. Neem extract with acetone and custard apple extract with methanol solvent were found effective to toxic and residual effects against pulse beetle of three plant extracts applied.
Asiat. Soc. Bangladesh, Sci. 46(1): 1-12, June 2020
Temporal Distribution and Abundance of Mosquito Vectors in Dhaka City
Authors: Sharower MG , Latif MA , Uddin SM 
Published: June 2021

Species of Anopheles, Aedes and Culex mosquitoes showed that Anopheles gambiae s.s had the highest number (43.5%) out of the three malaria vectors (viz. Anopheles gambiae, An. arabiensis and An. funestus). For Aedes and Culex species, Aedes aegypti (37.6%) and Culex fatigans (37.1%) had the highest prevalence out of their sibling species. Temperature and rainfall were highly correlated with the abundance of mosquito vectors. It was observed that the rainy season (March to October) recorded the highest number (Total 11 specie) of mosquito vectors collected with the peak (Aedes aegypty, 140) in the months of July (932) and August (976) while the lowest (333) collection was in the dry season (November to February) with lowest (333) in the month of February when there was little or no rains.
Asiat. Soc. Bangladesh, Sci. 46(1): 27-35, June 2020
Análisis hidrobiológico y sanitario de la quebrada Santa Mónica, Concordia Antioquia-Colombia
Authors: Serna Juan Pablo , Quintero Noris Emilse , Vélez Fabio de Jesús , Jaime Aguirre Néstor 
Published: June 2021

La Quebrada Santa Mónica es la fuente con el mayor aporte de agua al embalse la Nitrera, que abastece el consumo al municipio de Concordia, Antioquia; con el objetivo de conocer calidad de agua de la Quebrada y determinar si cumple con los criterios de calidad, se realizó la caracterización fisicoquímica y biológica empleando los macroinvertebrados acuáticos como bioindicadores. En tres estaciones de la quebrada, se tomaron muestras fisicoquímicas e hidrobiológicas durante tres campañas en el año 2017. Los resultados fisicoquímicos presentaron una variación espaciotemporal leve, se pudo determinar que el mes de noviembre se presentó el valor más alto de abundancia y riqueza de macroinvertebrados, siendo Phylloicus el taxa predominante. El índice BWWP/Col estuvo entre 52 y 119. La Quebrada Santa Mónica presenta una buena calidad de agua y la mayoría de los parámetros fisicoquímicos cumplen con la normatividad para ser fuente de abastecimiento de agua potable.
The Santa Monica creek is the main source of the Nitrera reservoir, which supplies the drinking water to the municipality of Concordia. To determine the quality of the water in the Creek, and if it accomplish the standards, a physical-chemical and biological characterization was carried out using aquatic macroinvertebrates as bioindicators. Physical-chemical and hydro-biological samples were taken at three stations in the creek during three campaigns in 2017. The physicochemical results presented a slight spatial-temporal variation, and we determined that November presented the highest abundance and richness values of macroinvertebrates, being Phylloicus the predominant taxa. The BWWP/Col index values were between 52 and 119. Santa Mónica Creek has a good water quality, and most of the physical-chemical parameters accomplish the regulations to be a source for drinkable water supply.
Síntesis y caracterización de biovidrios de fosfato por el método pirólisis de aerosol en llama
Authors: Velez-Saénz Juan Camilo , Betancur-Granados Natalia , Gutiérrez-Flórez Omar Dario 
Published: June 2021

Empleando el novedoso método pirólisis de aerosol en llama (FSP) se sintetizó por primera vez un biovidrio de fosfato de calcio en el sistema P2O5-CaO-Na2O. Las muestras obtenidas se caracterizaron mediante difracción de rayos X (DRX) y espectroscopía infrarroja de reflectancia difusa (DRIFTS), sirviendo esta última para seguir la cinética de biomineralización in-vitro durante 15 días en fluido corporal simulado (SBF). Mediante DRX se validó la naturaleza amorfa del biovidrio exhibiendo la fase whitlockita. El análisis DRIFTS reveló las bandas características de los grupos fosfatos en un rango de alrededor de los 500 a 1400 cm-1. Respectivamente, la evolución de las bandas de fosfatos en las muestras sumergidas en SBF indican la formación de apatita, proceso que siguió una cinética de pseudo- primer-orden de Lagergren.
Using the novel flame aerosol pyrolysis method (FSP), a calcium phosphate bioglass was synthesized for the first time in the P2O5-CaO-Na2O. The samples obtained were characterized by X-ray diffraction(XRD) and diffuse reflectance infrared spectroscopy (DRIFTS), the latter serving to follow in-vitro biomineralization kinetics for 15 days in simulated body fluid (SBF). Using XRD, the amorphous nature of the bioglass was validated by exhibiting the whitlockite phase.The DRIFTS analysis revealed the characteristic bands of the phosphate groups in a range of about 500 to 1400 cm-1. Respectively, the evolution of the phosphate bands in the samples submerged in SBF indicate the formation of apatite, a process that followed a pseudo-first-order Lagergren kinetics.
Coffee Challenge: Un juego para la enseñanza de patrones de diseño de software
Authors: González-Castaño Luz Eliana , Marroquín-Soto Sara Valentina , Maturana-González Grissa Vianney , Manjarrés-Betancur Roberto Antonio 
Published: June 2021

En ingeniería de software el aprendizaje basado en juegos ayuda a incrementar la efectividad del aprendizaje en el aula de clase y permite poner en práctica conocimientos adquiridos. Los patrones de diseño son soluciones reusables a problemas comunes en el diseño de software, permiten crear software limpio y mantenible, sin embargo para aplicar los patrones de diseño correctamente se requiere experiencia, por lo que es difícil aprenderlos. En este trabajo se investigaron los patrones de diseño, su estructura y posibles aplicaciones, además de revisar juegos educativos existentes en el ámbito de la computación. Posteriormente se crea un juego para enseñar patrones de diseño elegidos según la popularidad del patrón y su aplicación a un página web. El juego se evalúa con estudiantes del área de ingeniería de software y afines, y se discuten los resultados obtenidos en sesiones de pruebas realizadas.
Game-based learning related to software engineering aims to increase learning effectiveness in the classroom and allow knowledge acquired to be put into practice. Design patterns are reusable solutions to recurring problems in software design, creating clean and maintainable software. However, applying design patterns correctly requires experience, therefore, it is difficult for students to learn design patterns. In this article, the design patterns, their structure and possible applications were investigated, in addition to reviewing existing educational games in computing. Afterwards, we develop a game for teaching design patterns depending on the popularity of the pattern and its application to a web page. We evaluated the game with computer science students. Finally, we exhibit the results obtained by test pilot sessions.
High Neutrophil to Lymphocyte Ratio and Its Gene Signatures Correlate With Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction
Authors: Bai Bo , Cheng Min , Jiang Lingyan , Xu Jiabin , Chen Haibo , Xu Yun 
Published: June 2021

Aims: To evaluate the interrelation between neutrophil to lymphocyte ratio (NLR) coupled with gene signatures, inflammation, and diastolic dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF).Methods: The clinical profile of 172 patients with HFpEF (EF ≥ 50%) and 173 non-HF control individuals was analyzed retrospectively. The association between NLR and HFpEF and the predictive performance of NLR for HFpEF were assessed by the binary logistic regression analysis and the receiver operating characteristic curve (ROC). Multivariate linear regression models further examined the associations between NLR and high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and average septal-lateral E/e', respectively. The freshly isolated neutrophils from 30 HFpEF patients and 42 non-HF controls were subjected to transcriptomic profiling. The biomarkers related to neutrophil activation and inflammation were detected in serum samples.Results: The HFpEF patients in Southeast China were lean and had comorbidity burden and worse cardiac structure/function. Compared with non-HF control individuals, HFpEF patients had a rise in NLR. NLR displayed an independent association with HFpEF [adjusted odds ratio, 2.351; 95% CI, 1.464–3.776; p &lt; 0.001] and it predicted HFpEF with the area under the ROC 0.796 (95% CI, 0.748–0.845, p &lt; 0.001). The positive associations between NLR and hs-CRP, NT-proBNP, and mitral E/e' were found in HFpEF patients. Moreover, patients had significantly elevated serum levels of neutrophil elastase and inflammatory biomarkers, both of which correlated with the mitral E/e' ratio. Finally, multiple molecules that drive neutrophil degranulation and inflammation, such as S100A8/A9/A12 and PADI4, were transcriptionally up-regulated in neutrophils of HFpEF patients.Conclusions: The high NLR coupled with transcriptional activation of neutrophils correlates with systemic inflammation and functional impairment in HFpEF patients, which may suggest a causative role of neutrophils in the pathogenesis of the disease.
Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis
Authors: Roos Carolyn M. , Zhang Bin , Hagler Michael A. , Verzosa Grace C. , Huang Runqing , Oehler Elise A. , Arghami Arman , Miller Jordan D. 
Published: June 2021

Background: While a small number of studies suggest that oxidative stress has an influential role in fibrocalcific aortic valve disease (FCAVD), the roles of specific antioxidant enzymes in progression of this disease remain poorly understood. Here, we focused on selectively altering mitochondrial-derived oxidative stress—which has been shown to alter progression of a myriad of age-associated diseases—on the progression of molecular and phenotypic drivers of FCAVD.Methods: We generated low-density lipoprotein receptor-deficient, Apolipoprotein B100-only mice (LA) that were either haploinsufficient for MnSOD (LA-MnSOD+/−) or genetically overexpressing MnSOD (LA-MnSODTg/0). After 6 months of Western diet feeding, mice underwent echocardiography to assess valvular and cardiac function and tissues were harvested. Quantitative-RT PCR, immunohistochemistry, and histopathology were used to measure changes in molecular pathways related to oxidative stress, calcification, and fibrosis.Results: While reductions in MnSOD increased oxidative stress, there was not an overt phenotypic effect of MnSOD deficiency on valvular and cardiac function in LA-MnSOD+/− mice. While markers of canonical bone morphogenetic protein signaling tended to increase in valve tissue from LA-MnSOD+/− (e.g., p-SMAD1/5/8 and osterix), we did not observe statistically significant increases in osteogenic signaling. We did, however, observe highly significant reductions in expression of osteopontin, which were associated with significant increases in calcium burden in LA-MnSOD+/− mice. Reciprocally, genetically increasing MnSOD did not preserve valve function in LA-MnSODTg/0, but we did observe slight reductions in p-SMAD1/5/8 levels compared to their non-transgenic littermates. Interestingly, overexpression of MnSOD dramatically increased expression of osteopontin in valve tissue from LA-MnSODTg/0 mice, but was not sufficient to attenuate calcium burden when compared to their LA-MnSOD0/0 littermates.Conclusions: Collectively, this study demonstrates that maintenance of mitochondrial antioxidant capacity is important in preventing accelerated disease progression in a mouse model of FCAVD, but that effectively altering mitochondrial antioxidant capacity as a monotherapeutic approach to slow key histopathological and molecular drivers of FCAVD remains biologically and therapeutically challenging.
Gene Expression Profiles Analyzed Using Integrating RNA Sequencing, and Microarray Reveals Increased Inflammatory Response, Proliferation, and Osteoclastogenesis in Pigmented Villonodular Synovitis
Authors: Zhao Yang , Lv Jiaoyun , Zhang Hongwei , Xie Jiawei , Dai Hui , Zhang Xin 
Published: June 2021

BackgroundPigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis limits its effective therapy.MethodIn this study, gene expression profiles of six patients with PVNS, 11 patients with osteoarthritis (OA), nine patients with rheumatoid arthritis (RA) (E-MTAB-6141), and three healthy subjects (GSE143514) were analyzed using integrating RNA sequencing (RNA-seq) and microarray to investigate the PVNS transcriptome. Gene ontology, string, and cytoscape were used to determine the gene functional enrichment. Cell functional molecules were detected using flow cytometry or immunohistochemical test to identify the cell subset and function. CD14+cells were isolated and induced to osteoclast to evaluate the monocyte/macrophage function.ResultsThe most obvious local manifestations of PVNS were inflammation, including increased immune cells infiltration and cytokine secretion, and tumor phenotypes. High proportion of inflammatory cells, including T cells, natural killer (NK) cells, NKT cells, and B cells were recruited from the blood. Th17 and monocytes, especially classical monocytes but not nonclassical monocytes, increased in PVNS synovium. An obvious increase in osteoclastogenesis and macrophage activation was observed locally. Elevated expression of MMP9, SIGLEC 15, and RANK were observed in myeloid cell of PVNS than OA. When compared with RA, osteoclast differentiation and myeloid cell activation are PVNS-specific characters, whereas T cell activation is shared by PVNS and RA.ConclusionThe transcriptional expression characteristics of PVNS showed increased immune response, cell migration, and osteoclastogenesis. Osteoclast differentiation is only observed in PVNS but not RA, whereas T-cell activation is common in inflammatory arthritis.
Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function
Authors: O’Brien Aisling , Hanlon Megan Mary , Marzaioli Viviana , Wade Siobhan C. , Flynn Keelin , Fearon Ursula , Veale Douglas J. 
Published: June 2021

ObjectivesPsoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation, metabolic function, and invasive and migratory capacity.MethodsPrimary PsAFLS were isolated and cultured with JAKi (Peficitinib, Filgotinib, Baricitinib and Upadacitinib) in the presence of Oncostatin M (OSM). pSTAT3 expression in response to OSM was quantified by Western Blot analysis. Pro-inflammatory cytokines/chemokines were quantified by ELISA and cell migration by wound-repair scratch assays. Invasive capacity was examined using Matrigel™ invasion chambers and MMP multiplex MSD assays. PsAFLS bioenergetics was assessed using the Seahorse XFe Extracellular Flux Analyzer, which simultaneously quantifies two energetic pathways- glycolysis (ECAR) and oxidative phosphorylation (OCR). In parallel, inflammatory, invasive, and migratory genes were quantified by RT-PCR.ResultsOSM induces pSTAT3 expression in PsAFLS. OSM-induced secretion of MCP-1 and IL-6 was inhibited by all JAKi with Peficitinib, Baricitinib and Upadacitinib showing the greatest effect. In contrast, JAKi had no significant impact on IL-8 expression in response to OSM. PsAFLS cell invasion, migratory capacity and MMP1, 3, and 9 were suppressed following JAKi treatment, with Peficitinib showing the greatest effect. These functional effects were accompanied by a change in the cellular bioenergetic profile of PsAFLS, where JAKi significantly decreased glycolysis and the ECAR/OCR, resulting in a shift to a more quiescent phenotype, with Peficitinib demonstrating the most pronounced effect.ConclusionThis study demonstrates that JAK/STAT signalling mediates the complex interplay between inflammation and cellular metabolism in PsA pathogenesis. This inhibition shows effective suppression of inflammatory mechanisms that drive pathogenic functions of PsAFLS, further supporting the role of JAKi as a therapeutic target for the treatment of PsA.