bluuebunny/crossref_metadata_2025_split huggingface dataset:
Race, APOE genotypes, and cognitive decline among middle-aged urban adults
Authors: Beydoun May A. , Weiss Jordan , Beydoun Hind A. , Hossain Sharmin , Maldonado Ana I. , Shen Botong , Evans Michele K. , Zonderman Alan B. 
Published: June 2021

Abstract
Background
Associations of Apolipoprotein (APOE) ε2 or ε4 (APOE2 or APOE4) dosages with cognitive change may differ across racial groups.

Methods
Longitudinal data on 1770 middle-aged White and African American adults was compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS 2004-2013) study. APOE2 and APOE4 dosages were the two main exposures, while v1 and annual rate of change in cognitive performance (between v1 and v2) on 11 test scores were the main outcomes of interest (v1: 2004–2009 and v2: 2009–2013). Mixed-effects linear regression models were conducted adjusting for socio-demographic, lifestyle, and health-related potential confounders. Race (African American vs. White) and sex within racial groups were main effect modifiers.

Results
Upon adjustment for multiple testing and potential confounders, APOE4 allelic dosage was associated with faster decline on a test of verbal memory among Whites only (CVLT-List A: γ12 = − 0.363 ± 0.137, p = 0.008), but not among African Americans. In contrast, among African American women, APOE4 dosage was linked to slower decline on a test of attention (BTA: γ12 = + 0.106 ± 0.035, p = 0.002), while no association was detected among African American men. APOE2 and APOE4 dosages showed inconsistent results in other domains of cognition overall and across racial groups that did not survive correction for multiple testing.

Conclusions
In conclusion, APOE4 dosage was associated with faster decline on a test of verbal memory among Whites only, while exhibiting a potential protective effect among African American women in the domain of attention. Further longitudinal studies are needed to replicate our race and sex-specific findings.
Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder
Authors: Kerr-Gaffney Jess , Hayward Hannah , Jones Emily J. H. , Halls Daniel , Murphy Declan , Tchanturia Kate 
Published: June 2021

Abstract
Background
Recent research suggests a link between autism spectrum disorder (ASD) and anorexia nervosa (AN). Individuals with AN show high scores on measures of ASD symptoms, relative to individuals without AN, however, there are currently no studies directly comparing women with AN to women with ASD. The aim of the current study was to examine profiles of ASD symptoms in young women in the acute and recovered stages of AN, women with ASD, and typically developing controls (TD), on both self-report and clinical interview measures.

Methods
Four groups of participants aged 12–30 years were included (n = 218): AN, recovered AN (REC), ASD, and TD. Group differences on the Social Responsiveness Scale, 2nd edition (SRS-2), 10-item Autism Quotient (AQ-10), and the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) were examined. To explore similarities and differences in specific symptom profiles associated with AN and ASD, individual item endorsement on the ADOS-2 was also examined in AN, REC, and ASD.

Results
Across measures, women with ASD showed the highest scores, and TDs the lowest. Generally, individuals with AN and REC showed intermediate levels of ASD symptoms, scoring between the other two groups. However, AN and ASD did not differ on restricted interests and repetitive behaviour subscales. The ADOS-2 item ‘quality of social response’ adequately discriminated between ASD and non-ASD participants.

Limitations
A full diagnostic assessment for ASD was not provided for participants with AN/REC, nor were eating disorders assessed in the ASD group. Therefore, some diagnostic overlap between groups is possible. The cross-sectional design is another limitation.

Conclusions
The results suggest similarities in scores on both self-report and clinical interview measures in AN and ASD. However, individual ADOS-2 item analyses also revealed subtle differences, particularly in reciprocal social interaction. ASD symptoms may be a combination of both state and trait features in AN.
Optimized SQE atomic charges for peptides accessible via a web application
Authors: Schindler Ondřej , Raček Tomáš , Maršavelski Aleksandra , Koča Jaroslav , Berka Karel , Svobodová Radka 
Published: June 2021

Abstract
Background
Partial atomic charges find many applications in computational chemistry, chemoinformatics, bioinformatics, and nanoscience. Currently, frequently used methods for charge calculation are the Electronegativity Equalization Method (EEM), Charge Equilibration method (QEq), and Extended QEq (EQeq). They all are fast, even for large molecules, but require empirical parameters. However, even these advanced methods have limitations—e.g., their application for peptides, proteins, and other macromolecules is problematic. An empirical charge calculation method that is promising for peptides and other macromolecular systems is the Split-charge Equilibration method (SQE) and its extension SQE+q0. Unfortunately, only one parameter set is available for these methods, and their implementation is not easily accessible.

Results
In this article, we present for the first time an optimized guided minimization method (optGM) for the fast parameterization of empirical charge calculation methods and compare it with the currently available guided minimization (GDMIN) method. Then, we introduce a further extension to SQE, SQE+qp, adapted for peptide datasets, and compare it with the common approaches EEM, QEq EQeq, SQE, and SQE+q0. Finally, we integrate SQE and SQE+qp into the web application Atomic Charge Calculator II (ACC II), including several parameter sets.

Conclusion
The main contribution of the article is that it makes SQE methods with their parameters accessible to the users via the ACC II web application (https://acc2.ncbr.muni.cz) and also via a command-line application. Furthermore, our improvement, SQE+qp, provides an excellent solution for peptide datasets. Additionally, optGM provides comparable parameters to GDMIN in a markedly shorter time. Therefore, optGM allows us to perform parameterizations for charge calculation methods with more parameters (e.g., SQE and its extensions) using large datasets.

Graphic Abstract
On the impact of heterogeneity-aware mesh partitioning and non-contributing computation removal on parallel reservoir simulations
Authors: Thune Andreas , Cai Xing , Rustad Alf Birger 
Published: June 2021

AbstractParallel computations have become standard practice for simulating the complicated multi-phase flow in a petroleum reservoir. Increasingly sophisticated numerical techniques have been developed in this context. During the chase of algorithmic superiority, however, there is a risk of forgetting the ultimate goal, namely, to efficiently simulate real-world reservoirs on realistic parallel hardware platforms. In this paper, we quantitatively analyse the negative performance impact caused by non-contributing computations that are associated with the “ghost computational cells” per subdomain, which is an insufficiently studied subject in parallel reservoir simulation. We also show how these non-contributing computations can be avoided by reordering the computational cells of each subdomain, such that the ghost cells are grouped together. Moreover, we propose a new graph-edge weighting scheme that can improve the mesh partitioning quality, aiming at a balance between handling the heterogeneity of geological properties and restricting the communication overhead. To put the study in a realistic setting, we enhance the open-source Flow simulator from the OPM framework, and provide comparisons with industrial-standard simulators for real-world reservoir models.
Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro
Authors: Ma Hongfang , Li Rui , Jiang Longguang , Qiao Songlin , Chen Xin-xin , Wang Aiping , Zhang Gaiping 
Published: June 2021

AbstractPorcine reproductive and respiratory syndrome (PRRS) is a serious disease burdening global swine industry. Infection by its etiological agent, PRRS virus (PRRSV), shows a highly restricted tropism of host cells and has been demonstrated to be mediated by an essential scavenger receptor (SR) CD163. CD163 fifth SR cysteine-rich domain (SRCR5) is further proven to play a crucial role during viral infection. Despite intense research, the involvement of CD163 SRCR5 in PRRSV infection remains to be elucidated. In the current study, we prepared recombinant monkey CD163 (moCD163) SRCR5 and human CD163-like homolog (hCD163L1) SRCR8, and determined their crystal structures. After comparison with the previously reported crystal structure of porcine CD163 (pCD163) SRCR5, these structures showed almost identical structural folds but significantly different surface electrostatic potentials. Based on these differences, we carried out mutational research to identify that the charged residue at position 534 in association with the one at position 561 were important for PRRSV-2 infection in vitro. Altogether the current work sheds some light on CD163-mediated PRRSV-2 infection and deepens our understanding of the viral pathogenesis, which will provide clues for prevention and control of PRRS.
Effects of carbon concentration, oxygen, and controlled pH on the engineering strain Lactiplantibacillus casei E1 in the production of bioethanol from sugarcane molasses
Authors: Wang Song , Tian Ran , Liu Buwei , Wang Hongcai , Liu Jun , Li Chenghui , Li Mingyue , Evivie Smith Etareri , Li Bailiang 
Published: June 2021

AbstractSugarcane molasses are considered a potential source for bioethanol’s commercial production because of its availability and low market price. It contains high concentrations of fermentable sugars that can be directly metabolized by microbial fermentation. Heterofermentative lactic acid bacteria, especially Lactiplantibacillus casei, have a high potential to be a biocatalyst in ethanol production that they are characterized by strong abilities of carbohydrate metabolism, ethanol synthesis, and high alcohol tolerance. This study aimed to evaluate the feasibility of producing ethanol by Lactiplantibacillus casei used the ethanologen engineering strain L. casei E1 as a starter culture and cane molasses as substrate medium. The effects of environmental factors on the metabolism of L. casei E1 were analyzed by high-performance liquid chromatography (HPLC) system, and the gene expression of key enzymes in carbon source metabolism was detected using quantitative real-time PCR (RT–qPCR). Results showed that the strain could grow well, ferment sugar quickly in cane molasses. By fermenting this bacterium anaerobically at 37 °C for 36 h incubation in 5 °BX molasses when the fermenter’s pH was controlled at 6.0, ethanol yield reached 13.77 g/L, and carbohydrate utilization percentage was 78.60%. RT-qPCR results verified the strain preferentially ferment glucose and fructose of molasses to ethanol at the molecular level. In addition, the metabolism of sugars, especially fructose, would be inhibited by elevating acidity. Our findings support the theoretical basis for exploring Lactic acid bacteria as a starter culture for converting sugarcane molasses into ethanol.
Seven key parameters that facilitate clinical pharmacy practice: a comparison between Israel and the United States
Authors: Rose Adam J. , Witt Daniel , Azran Carmil , Nissan Ran 
Published: June 2021

AbstractClinical pharmacists have advanced training that enables them to manage medication therapy, including prescribing, titrating, and discontinuing medications, in order to achieve therapeutic goals. In some countries, such as the United States, advances in training, responsibility, legal frameworks, and public acceptance of new roles have proceeded in parallel to expand the scope and contribution of clinical pharmacists over several decades. In this manuscript, we detail seven discrete key parameters of professional advancement for clinical pharmacists, corresponding to the seven areas in which they must advance in order to contribute fully to delivering high-quality medical care. For each key parameter, we briefly summarize the progress made in the United States to date, as well as goals for future progress. We then compare this to the development of the analogous key parameter in Israel. We found that on some key parameters, the development of clinical pharmacy in Israel lags behind the United States. This manuscript can provide a roadmap for the future advancement of clinical pharmacy in Israel, toward its full realization as a profession that can contribute to delivering high-quality medical care.
Seroprevalence of Chlamydia abortus infection in yak (Bos grunniens) in Tibet, China
Authors: Liang Lin , Wen Yuan , Li Zhaocai , Liu Ping , Liu Xing , Tan Shuming , Liu Donghui , Zhou Jizhang , Tong Dewen 
Published: June 2021

AbstractChlamydiaspp. are prevalent zoonotic pathogens that infect a wide variety of host species.Chlamydia abortus(C. abortus) infection in yaks has been reported in Gansu and Qinghai province, China. However, no data aboutC. abortusinfection are available in yaks in Tibet, China. A total of 938 serum samples was collected from yaks in Tibet, China and specific antibodies againstC. abortuswere detected by the enzyme-linked immunosorbent assay (ELISA). The results showed that the overall seroprevalence ofC. abortusin yaks was 104/938 (11.1 %, 95 % confidence interval [CI] 9.1–13.1). The prevalence in female and male yaks was 59/556 (10.6 %, 95 % CI 8.0-13.2) and 45/382 (11.8 %, 95 % CI 8.5–15.0), respectively with no significant difference (p > 0.05). The seroprevalence of antibodies toC. abortusin yaks ranged from 8.0 to 18.2 % among the six different areas, and the difference was also without statistical significance (p > 0.05). The prevalence among different age groups ranged from 7.0 to 15.9 %, with a higher prevalence among 1 to 2 years age category. The results demonstrate the presence ofC. abortusinfection in yaks in Tibet and may pose a risk for the general yak populations in addition to its potential impact on public health and the local Tibetan economy. To our knowledge, this is the first seroprevalence survey ofC. abortusin yaks in Tibet, China.
Effect modification of the association between comorbidities and severe course of COVID-19 disease by age of study participants: a systematic review and meta-analysis
Authors: Fernández Villalobos Nathalie Verónica , Ott Jördis Jennifer , Klett-Tammen Carolina Judith , Bockey Annabelle , Vanella Patrizio , Krause Gérard , Lange Berit 
Published: June 2021

Abstract
Background
Comprehensive evidence synthesis on the associations between comorbidities and behavioural factors with hospitalisation, intensive care unit (ICU) admission, and death due to COVID-19 is required for deriving national and international recommendations on primary targets for non-pharmacological interventions (NPI) and vaccination strategies.

Methods
We performed a rapid systematic review and meta-analysis on studies and publicly accessible data to quantify associations between predisposing health conditions, demographics, behavioural factors on the one hand and hospitalisation, ICU admission, and death from COVID-19 on the other hand. We provide ranges of reported and calculated effect estimates and pooled relative risks derived from a meta-analysis and meta-regression.

Results
Seventy-five studies were included in qualitative and 74 in quantitative synthesis, with study populations ranging from 19 to 44,672 COVID-19 cases. The risk of dying from COVID-19 was significantly associated with cerebrovascular [pooled relative risk (RR) 2.7 (95% CI 1.7–4.1)] and cardiovascular [RR 3.2 (CI 2.3–4.5)] diseases, hypertension [RR 2.6 (CI 2.0–3.4)], and renal disease [RR 2.5 (CI 1.8–3.4)], with high heterogeneity in pooled estimates, partly but not solely explained by age of study participants. For some comorbidities, our meta-regression showed a decrease in effect on the severity of disease with a higher median age of the study population. Compared to death, associations between several comorbidities and hospitalisation and ICU admission were less pronounced.

Conclusions
We obtained robust estimates on the magnitude of risk for COVID-19 hospitalisation, ICU admission, and death associated with comorbidities, demographic, and behavioural risk factors and show that these estimates are modified by age of study participants. This interaction is an important finding to be kept in mind for current vaccination strategies and for the protection of individuals with high risk for a severe COVID-19 course.
What are the variables associated with Altmetric scores?
Authors: Araujo Amanda Costa , Vanin Adriane Aver , Nascimento Dafne Port , Gonzalez Gabrielle Zoldan , Costa Leonardo Oliveira Pena 
Published: June 2021

Abstract
Background
Social media has been used to disseminate the contents of scientific articles. To measure the impact of this, a new tool called Altmetric was created. Altmetric aims to quantify the impact of each article through online media. This systematic review aims to describe the associations between the publishing journal and published article variables and Altmetric scores.

Methods
Searches on MEDLINE, EMBASE, CINAHL, CENTRAL, and Cochrane Library were conducted. We extracted data related to both the publishing article and the publishing journal associated with Altmetric scores. The methodological quality of included articles was analyzed by the Appraisal Tool for Cross-sectional Studies.

Results
A total of 19 articles were considered eligible. These articles summarized a total of 573,842 studies. Citation counts, journal impact factor, access counts, papers published as open access, and press releases generated by the publishing journal were associated with Altmetric scores. The magnitude of these associations ranged from weak to strong.

Conclusion
Citation counts and journal impact factor are the most common variables associated with Altmetric scores. Other variables such as access counts, papers published in open access journals, and the use of press releases are also likely to be associated with online media attention.

Systematic review registration
This review does not contain health-related outcomes. Therefore, it is not eligible for registration.
Inequalities and pth moment exponential stability of impulsive delayed Hopfield neural networks
Authors: Zhang Yutian , Chen Guici , Luo Qi 
Published: June 2021

AbstractIn this paper, thepth moment exponential stability for a class of impulsive delayed Hopfield neural networks is investigated. Some concise algebraic criteria are provided by a new method concerned with impulsive integral inequalities. Our discussion neither requires a complicated Lyapunov function nor the differentiability of the delay function. In addition, we also summarize a new result on the exponential stability of a class of impulsive integral inequalities. Finally, one example is given to illustrate the effectiveness of the obtained results.
Blowup for nonlinearly damped viscoelastic equations with logarithmic source and delay terms
Authors: Park Sun-Hye 
Published: June 2021

AbstractIn this work, we investigate blowup phenomena for nonlinearly damped viscoelastic equations with logarithmic source effect and time delay in the velocity. Owing to the nonlinear damping term instead of strong or linear dissipation, we cannot apply the concavity method introduced by Levine. Thus, utilizing the energy method, we show that the solutions with not only non-positive initial energy but also some positive initial energy blow up at a finite point in time.
Perceived family cohesion, social support, and quality of life in patients undergoing treatment for substance use disorders compared with patients with mental and physical disorders
Authors: Birkeland Bente , Weimand Bente , Ruud Torleif , Maybery Darryl , Vederhus John-Kåre 
Published: June 2021

Abstract
Purpose
Support from family and other social network elements can be important in helping patients to cope with practical and emotional consequences of diseases. The aim of the study was to examine perception of family and social support and quality of life (QoL) in patients undergoing treatment for substance use disorders (SUDs). We compared them with patients in treatment for mental disorders (MDs) and physical disorders (PDs).

Methods
We used data from a national multicenter study that recruited patients (N  =  518) from three treatment domains; SUD treatment units, MD treatment units, and PD treatment units (severe neurological conditions or cancer). Data on family cohesion, social support, and QoL were compared across patient groups. In addition, data on health variables was collected. We used a multiple linear regression procedure to examine how health and support variables were associated with QoL.

Results
Family cohesion and social support in the SUD and MD groups were rated at similarly low levels, substantially lower than in the PD group. The SUD group exhibited a somewhat lower QoL than did the PD group, but their QoL was still in the near-to-normal range. In contrast, the MD group had markedly low QoL. When examining factors associated with QoL, we found that greater family cohesion and social support were positively associated with QoL. Mental distress was the strongest factor, and was negatively associated with QoL (beta − 0.15, 95% CI  =  − 0.17/− 0.14, p  <  0.001).

Conclusion
Service providers need to be aware of the weaker networks and less regulatory family and/or social support available to patients with SUDs. Providers should focus consistently on the social networks of patients and include patients’ families in treatment processes.
Tanzanian primary healthcare workers’ experiences of antibiotic prescription and understanding of antibiotic resistance in common childhood infections: a qualitative phenomenographic study
Authors: Emgård Matilda , Mwangi Rose , Mayo Celina , Mshana Ester , Nkini Gertrud , Andersson Rune , Msuya Sia E. , Lepp Margret , Muro Florida , Skovbjerg Susann 
Published: June 2021

Abstract
Background
Antibiotic resistance is a threat to global child health. Primary healthcare workers play a key role in antibiotic stewardship in the community, but few studies in low-income countries have described their experiences of initiating antibiotic treatment in children. Thus, the present study aimed to describe primary healthcare workers’ experiences of antibiotic prescription for children under 5 years of age and their conceptions of antibiotic resistance in Northern Tanzania.

Methods
A qualitative study involving individual in-depth interviews with 20 prescribing primary healthcare workers in Moshi urban and rural districts, Northern Tanzania, was performed in 2019. Interviews were transcribed verbatim, translated from Kiswahili into English and analysed according to the phenomenographic approach.

Findings
Four conceptual themes emerged during the analysis; conceptions in relation to the prescriber, the mother and child, other healthcare actors and in relation to outcome. The healthcare workers relied mainly on clinical examination and medical history provided by the mother to determine the need for antibiotics. Confidence in giving advice concerning non-antibiotic treatment varied among the participants and expectations of antibiotic treatment were perceived to be common among the mothers. Antibiotic resistance was mainly perceived as a problem for the individual patient who was misusing the antibiotics.

Conclusions
To increase rational antibiotic prescription, an awareness needs to be raised among Tanzanian primary healthcare workers of the threat of antibiotic resistance, not only to a few individuals, but to public health. Guidelines on childhood illnesses should be updated with advice concerning symptomatic treatment when antibiotics are not necessary, to support rational prescribing practices and promote trust in the clinician and mother relationship.