bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supervisory capability of supervisor board, incentives to supervisor board, and stock price crash risk
Authors: Yin Haiyuan , Chen Baifan , Wang Xiaoxiao 
Published: September 2021

AbstractWe analyzed the impact of the supervisory capability of the supervisory board and the incentive to the supervisory board on stock price crash risk. We found that the exercise quality of the members of the supervisory board will affect stock price crash risk. The improvement of their education degree can inhibit the risk of the stock price crash, and there is a negative correlation between the average age of the members and stock price crash risk. In terms of supervision incentives, the higher the shareholding ratio of the supervisory board and the higher the proportion of unpaid supervisors, the lower the stock price crash risk.
MicroRNA‐33b replacement effect on growth and migration inhibition in ovarian cancer cells
Authors: Liu Jin , Wang Weiming , Chen Limin , Li Yachai , Zhao Shuimiao , Liang Yijuan 
Published: September 2021

AbstractPurposeOvarian cancer is a devastating gynecological disease which is considered the major cause of cancer fatality around the world. The down‐regulation of microRNA‐33b (miR‐33b) was reported in some malignancies. Hence, we transfected the miR‐33b mimic into SKOV3 cells and evaluated the impacts of this interference on the growth and migration repression of these tumor cells as well as on targeted genes expression.MethodsIn our study, transfecting the miR‐33b mimic and inhibitor, negative control (NC), and NC inhibitor were established using Lipofectamine 2000. The cytotoxic effects of miR‐33b were evaluated by MTT. To assess the miR‐33b effects on cell migration, a scratching test was applied. The expression levels of miR‐33b, ADAMTS, C‐Myc, MMP9, K‐Ras, and CXCR4 were evaluated using qRT‐PCR.ResultsThese findings indicate that transfection of miR‐143 mimic had no marked effects on the SKOV3 cell line. As expected, miR‐33b relative expression levels were as follows: miR‐33b mimic >NC and NC inhibitor >miR‐33b inhibitor (p < 0.01). Moreover, transfected miR‐33b mimic could suppress SKOV3 cells’ proliferation, whereas transfected miR‐33b inhibitor could promote cell proliferation (p < 0.01). MiR‐33b overexpression significantly down‐regulated the MMP9, CXCR‐4, c‐Myc, ADAMTS, and K‐Ras mRNA levels (p < 0.05).ConclusionAs expected, these results confirm the tumor‐suppressive effect of miR‐33b in the SKOV3 ovarian cancer cell line by reducing cell survival, proliferation, and migration.
Evaluating and reflecting on coproduction of protected area management plans
Authors: Roux Dirk J. , Nel Jeanne L. , Freitag Stefanie , Novellie Peter , Rosenberg Eureta 
Published: September 2021

ABSTRACTProtected areas are complex social‐ecological systems, hence their management should be guided by engagement and co‐learning with diverse stakeholders. The challenge of effective stakeholder participation has generated a body of literature on the design and facilitation of coproduction processes. In this study, we used this literature to develop a principle‐based framework for assessing coproduction. We then applied this framework to evaluate how well “adaptive planning” (a sub‐process of adaptive management used for visioning and objective setting with stakeholders), as applied to the Garden Route National Park in South Africa, aligned with the ideals of coproduction. Our analysis revealed shortcomings in the adaptive planning process, which could be improved through broadening the agenda beyond the mandate and control of national parks, empowering collective agency among a wider stakeholder network, and embedding co‐learning with stakeholders as an ongoing journey. A significant finding was that adaptive management does not align well with the ideals of coproduction, which may be better supported by an adaptive co‐management approach. The latter is particularly necessary in complex national parks that are diverse in terms of both ecosystems and stakeholders, and where governance may be contested.
Is the incision type important for the development of hernia in liver transplant patients?
Authors: Zarbaliyev Elbrus , Sevmiş Murat , Kilercik Hakan , Çelik Sebahattin , Aktaş Sema , Çağlıkülekçi Mehmet , Sevmiş Şinasi 
Published: September 2021

AbstractObjectiveIn this study, we aimed to investigate the rates and causes of incisional hernia that developed in the postoperative follow‐up of patients who underwent liver transplantation.Material and methodThe results of patients who underwent LT by using three different incisions at the İstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital organ transplant center between January 2015 and December 2019 were retrospectively analyzed. Patients were divided into Chevron (group‐1), reverse T (group‐2), and J incisions (group‐3) and hernia development rates were examined.ResultsThere was no significant difference in terms of incisional hernia in groups 1 and 2 according to the incision type (p = .723). Incisional hernia rate was significantly lower in the J incision group (p < .001). When the factors that increase the development of hernia in all LT patients were examined, it was seen that male gender (p = .021), high BMI rate (p = .003), postoperative bleeding (p = .018), and wound infection (p = .039) caused a significant increase in risk.ConclusionThe incision, which is made during liver transplant, is important for the development of hernia. The J incision has a low hernia development rate without causing access problems. Regardless of the incision, high BMI index, male gender, postoperative bleeding, and wound infection increase the development of incisional hernia in liver transplant patients.
Combining expert‐based and computational approaches to design protected river networks under climate change
Authors: Floury Mathieu , Pollock Laura J. , Buisson Laëtitia , Thuiller Wilfried , Chandesris André , Souchon Yves 
Published: September 2021

AbstractAimEstimate the current and future distribution of brown trout and identify priority areas for conservation of the species.LocationRhône River basin and Mediterranean streams.MethodsWe first developed a spatially explicit species distribution model to estimate the current and future distribution of brown trout for three time horizons (2030, 2055 and 2080) and two climate change scenarios (RCP 4.5 and RCP 8.5). We then performed a prioritization analysis to identify priority areas for brown trout conservation, accounting for: (a) spatial dependencies along the riverine system, (b) several sources of uncertainty arising from climate‐related forecasts and (c) different protected area scenarios by comparing hypothetical, optimal protected networks to an actual protected network designed by regional fish experts.ResultsFuture projections of brown trout densities exhibited a general trend towards a gradual range contraction, with a significant risk of extirpation across mountainous regions of low to mid‐elevation. Overall, the projected current and future distributions were well‐covered by the existing protected network. In addition, up to 70% of the river reaches included in this expert‐based protection network were also priorities in the optimal priority set (e.g. the best set of areas to maximize biodiversity protection). Finally, a large proportion of these reaches were invariably identified regardless of climate change scenarios and uncertainties or spatial dependencies.Main conclusionsOur analytical approach highlighted priority areas for brown trout conservation which were robust to a set of climate and connectivity assumptions. This core priority network could be further refined by taking into account key fine‐scale processes like thermal refugia. Therefore, we advocate for combining computational and expert‐based approaches in conservation planning of riverine ecosystems to achieve a relevant consensus between regional‐scale management and fine‐grain ecological knowledge.
Efficacy and safety of antiseizure medication for Lennox–Gastaut syndrome: a systematic review and network meta‐analysis
Authors: Zhang Lanlan , Wang Juan , Wang Chengzhong 
Published: September 2021

AimTo compare and rank the efficacy and safety of antiseizure medication (ASM) in patients with Lennox–Gastaut syndrome (LGS).MethodWe included randomized controlled trials (RCTs) assessing the efficacy of ASM for LGS compared with placebo or with each other. The efficacy and safety were reported in terms of an at least 50% monthly seizure frequency reduction in drop seizures, dropout, and serious adverse events. Outcomes were ranked according to the surface under the cumulative ranking curve (SUCRA).ResultsA total of eight RCTs with 1171 patients were included, involving six ASMs: lamotrigine, rufinamide, cannabidiol, topiramate, clobazam, and felbamate. The calculated SUCRA showed that rufinamide, cannabidiol, and topiramate had the highest probability of achieving a response; however, no significant differences were found among these treatments. Cannabidiol, topiramate, and rufinamide were more likely to result in dropouts; moreover, a significantly greater percentage of patients receiving cannabidiol experienced premature discontinuation as compared to placebo, clobazam, and lamotrigine.InterpretationAll ASMs showed a significantly higher response rate than placebo. SUCRA ranking demonstrated that rufinamide and cannabidiol are more efficacious than other treatments in reducing drop seizures. However, there was no significant difference between these treatments.
Is automatic enrollment consistent with a life cycle model?
Authors: Scott Jason S. , Shoven John B. , Slavov Sita N. , Watson John G. 
Published: September 2021

AbstractWe examine retirement saving for young adults in a life cycle model. We find that optimal retirement saving is zero for liquidity‐constrained young adults who anticipate significant earnings growth. With a plausible age‐earnings profile for college‐educated workers, retirement saving does not begin until the late 30s or early 40s. Workers facing a flat earnings profile begin saving much sooner. Participating may be optimal for younger workers facing steep earnings profiles if they anticipate switching jobs and cashing out after 1–2 years. Our results suggest that automatically enrolling workers, regardless of age, is not consistent with a life cycle model.
Cryptic local adaptation of the herbivorous ladybird beetle Henosepilachna pustulosa in the ability to use the thistle Cirsium boreale
Authors: Fujiyama Naoyuki , Kawasaki Jun‐ichi , Katakura Haruo 
Published: September 2021

AbstractLocal adaptation to different host plants is important in the diversification of phytophagous insects. Thus far, much evidence of the local adaptation of insects with respect to host use at the physiological level has been gathered from systems involving less mobile insects and/or divergent hosts such as plants belonging to different families or genera. On the other hand, the prevalence of such local adaptation of insects with moderate or high dispersal ability to the intraspecific variation of herbaceous hosts is largely unknown. In the present study, we examined the occurrence and degree of local adaptation of the herbivorous ladybird beetle Henosepilachna pustulosa (Kôno) (Coleoptera: Coccinellidae) to its primary host, the thistle Cirsium boreale Kitam. (Asteraceae), through reciprocal laboratory experiments using beetles and thistles from three locations with a range of approximately 200 km. Concerning the larval developmental ability, obvious patterns of local adaptation to the thistles from respective natal locations were detected, at least in some combinations of beetle populations. Similar tendencies were detected concerning adult feeding acceptance, although the statistical support was somewhat obscure. Overall, our results indicate that the degree of local adaptation of insect species with moderate dispersal ability to conspecific herbaceous hosts is occasionally as strong as that involving less mobile insects and/or heterospecific hosts, indicating the potential of such cryptic local adaptation to promote ecological/genetic differentiation of phytophagous insect populations.
Sustainable development goals in the English language high school curriculum in Turkey
Authors: Arslan Sezen , Curle Samantha 
Published: September 2021

AbstractThe study on which this article reports examined the representation of the Sustainable Development Goals (SDGs) in the English language syllabus and English language senior high‐school textbooks in Turkey. The learning objectives associated with the SDGs were also investigated. The syllabus and the textbooks including Teenwise, High School English 10, Silver Lining and Count Me In were examined. Semi‐structured interviews were also conducted with eleven high‐school English teachers to gain further insight into the place for SDGs and their related learning objectives in the English language high school curriculum. We found that the syllabus has a low frequency of engagement with SDGs. Also, that there is a tendency in the textbooks to include the theme of health that is related to the SDG of Education for Sustainable Development (ESD). The learning objectives set for ESD were mostly cognitive‐oriented. Interviews revealed that teachers favour the incorporation of a variety of SDGs in textbooks. They believe that prioritising sustainability in textbooks can help secure a more sustainable future for learners. Implications of this for pedagogy include, among other, that extending teaching and learning activities to activate socio‐emotional and behavioural development would benefit learners and would allow for a more balanced engagement with SDGs in English language teaching.
Use of venography including the dorsal 60° proximal‐palmaro‐/plantaro‐distal oblique to improve the evaluation of nonlaminitic digital disease of the horse
Authors: Trolinger‐Meadows K. , Morton A. , McCarrel T. , Porter E. , Dryden V. 
Published: September 2021

SummaryBackgroundMany common nonlaminitic conditions of the equine digit can be diagnosed radiographically, although vascular disturbance cannot be evaluated without use of contrast venography. Digital venography is commonly used to assess vascular disturbance in horses with laminitis. Routine venography projections include the lateromedial (LM) and dorsopalmar/dorsoplantar (DP) projections, although these do not provide complete assessment of the digital vasculature.ObjectivesThe purpose of this study was to describe digital venography as a diagnostic tool for nonlaminitic disease of the digit of horses including the dorsal 60° proximal‐palmaro‐/plantaro‐distal oblique (60° DP) in addition to the standard LM and DP projections.Study designRetrospective descriptive case series.MethodsMedical records were reviewed to identify patients with nonlaminitic disease that had digital venography including LM, DP and 60° DP projections. Horses free of disease of the digit were utilised for comparison. Images were reviewed, and presence or absence of radiographic and venographic abnormalities was determined individually.ResultsVenography revealed vascular abnormalities in horses with digital keratoma, complex digital abscessation and simple digital abscessation. The inclusion of the 60° DP projection allowed for better determination of the location and extent of vascular disturbance of the distal phalanx.Main limitationsLimitations of the study include the small sample size and retrospective nature, as well as lack of literature describing vascular disturbances in nonlaminitic processes.ConclusionsDigital venography can be considered for evaluation of submural disease of the digit of horses. For more complete assessment of the distal phalangeal vasculature, the 60° DP projection should be included in all digital venographic studies.
Descriptive analysis of bleeding symptoms in haemophilia carriers enrolled in the ATHNdataset
Authors: Puetz John , Cheng Dunlei 
Published: September 2021

AbstractBackgroundSeveral studies have reported that haemophilia carriers have a bleeding tendency independent of factor activity. However, investigations have been fraught with methodological concerns. The ATHNdataset houses the largest data set of haemophilia carriers in the world. We undertook an analysis of haemophilia carriers in this data set using methodologies that characterize bleeding symptoms in carriers.AimDetermine the proportion of haemophilia carriers who have a normal bleeding score (BLS) and factors that affect the BLS.MethodsThe ATHNdataset was queried for haemophilia carriers with a documented BLS. Collected data included demographics, ISTH‐BAT score, factor activity level, type of haemophilia (A or B), genotype and geographic residence.ResultsNine hundred twenty‐two haemophilia carriers in the ATHNdataset reported a BLS. When adjusted for age, 74% reported a normal score. Logistic regression identified age, factor activity level, ethnicity and region of residence as risk factors for an abnormal score.ConclusionsThe majority of haemophilia carriers (74%) in the ATHNdataset had a normal BLS, including the majority (59%) with factor activity levels < 40 IU/dl. Conversely, 24% of haemophilia carriers with a factor activity level 40 IU/dl reported an abnormal BLS. These results are consistent with previous studies of haemophilia carriers. Additional investigation is needed to determine why a majority of haemophilia carriers with low factor activity levels report normal BLSs while a significant minority of haemophilia carriers with normal activity levels report abnormal BLSs.
All‐cause mortality and causes of death in persons with haemophilia: A systematic review and meta‐analysis
Authors: Alam Arafat Ul , Karkhaneh Mohammad , Attia Tyson , Wu Cynthia , Sun Haowei (Linda) 
Published: September 2021

AbstractIntroductionImprovements in haemophilia treatment over the last decades resulted in increased life expectancy in persons with haemophilia (PWH).AimWe conducted a systematic review and meta‐analysis to examine all‐cause mortality and causes of death among PWH.MethodsWe systematically searched EMBASE, MEDLINE, Web of Science, CINAHL and Cochrane central register of controlled trials from inception through March 15, 2021. Studies that reported a mortality estimate of PWH compared with the general population and/or reported causes of death were included. Random‐effects meta‐analysis with inverse variance method was used to obtain pooled estimates. We stratified the analysis by the year of cohort entry (before 2000 vs after 2000).ResultOf the 4769 studies identified, 52 met the eligibility criteria. The pooled all‐cause standardized mortality ratio (SMR) from 9 studies in PWH was 1.93 (95% CI 1.38–2.70; I2 = 97%). The pooled SMRs before and after the year 2000 were 2.40 (95% CI 1.92–3.00; I2 = 87%) and 1.20 (95% CI 1.03–1.40; I2 = 62%), respectively. Before the year 2000, 31.2% deaths occurred due to HIV followed by haemorrhage (26.0%), cardiovascular disease (18.2%), liver disease (9.0%), and cancer (8.9%). Fewer (13.9%) deaths were attributable to HIV after the year 2000 with the proportion of deaths due to haemorrhage remaining unchanged.ConclusionWith treatment advances, mortality in PWH has declined over the last few decades approaching that of the general population. However, haemorrhage remains a leading cause of death requiring further attention.
Lenvatinib versus Sorafenib as first‐line treatment in hepatocellular carcinoma: A multi‐institutional matched case‐control study
Authors: Rimini Margherita , Shimose Shigeo , Lonardi Sara , Tada Toshifumi , Masi Gianluca , Iwamoto Hideki , Lai Eleonora , Burgio Valentina , Hiraoka Atsushi , Ishikawa Toru , Soldà Caterina , Shirono Tomotake , Vivaldi Caterina , Takaguchi Koichi , Shimada Noritomo , Astara Giorgio , Koga Hironori , Nouso Kazuhiro , Joko Kouji , Torimura Takuji , Hiasa Yoichi , Salani Francesca , Scartozzi Mario , Cascinu Stefano , Casadei‐Gardini Andrea 
Published: September 2021

AbstractBackgroundAdvanced Hepatocarcinoma (HCC) is an important health problem worldwide. Recently, the REFLECT trial demonstrated the non‐inferiority of Lenvatinib compared to Sorafenib in I line setting, thus leading to the approval of new first‐line standard of care, along with Sorafenib.Aims and methodsWith aim to evaluate the optimal choice between Sorafenib and Lenvatinib as primary treatment in clinical practice, we performed a multicentric analysis with the propensity score matching on 184 HCC patients.ResultsThe median overall survival (OS) were 15.2 and 10.5 months for Lenvatinib and Sorafenib arm, respectively. The median progression‐free survival (PFS) was 7.0 and 4.5 months for Lenvatinib and Sorafenib arm, respectively. Patients treated with Lenvatinib showed a 36% reduction of death risk (p = 0.0156), a 29% reduction of progression risk (p = 0.0446), a higher response rate (p < 0.00001) and a higher disease control rate (p = 0.002). Sorafenib showed to be correlated with more hand‐foot skin reaction and Lenvatinib with more hypertension and fatigue. We highlighted the prognostic role of Barcelona Clinic Liver Cancer (BCLC) stage, Eastern Cooperative Oncology Group Performance Status (ECOG‐PS), bilirubin, alkaline phosphatase and eosinophils for Sorafenib. Conversely, albumin, aspartate aminotransferase (AST), alkaline phosphatase and Neutrophil‐Lymphocyte Ratio (NLR) resulted prognostic in Lenvatinib arm. Finally, we highlighted the positive predictive role of albumin > Normal Value (NV), ECOG > 0, NLR < 3, absence of Hepatitis C Virus positivity, and presence of portal vein thrombosis in favor of Lenvatinib arm. Eosinophil < 50 and ECOG > 0 negatively predicted the response to Sorafenib.ConclusionSLenvatinib showed to better perform in a real‐word setting compared to Sorafenib. More researches are needed to validate the predictor factors of response to Lenvatinib rather than Sorafenib.
Potential relationship between clinical symptoms and the root canal microbiomes of root filled teeth based on the next‐generation sequencing
Authors: Hou Yajing , Wang Liu , Zhang Lan , Tan Xuelian , Huang Dingming , Song Dongzhe 
Published: September 2021

AbstractAimTo determine the microorganism in root canal systems of root filled teeth with periapical disease and their relationship with clinical symptoms using next‐generation sequencing.MethodologyThe roots of 10 extracted teeth were collected from 10 patients who presented with post‐treatment apical periodontitis (PTAP; six with symptoms and four without symptoms). Each root was divided horizontally into two parts (apical and coronal segments) and cryo‐pulverized. Microbial communities were detected using 16S rDNA hypervariable V3‐V4 region. The diversity, principal coordinate analysis and linear discriminant analysis effect size were performed in the symptomatic and asymptomatic groups (apical and coronal parts respectively). A Mann–Whitney test and an analysis of similarities were applied for intergroup analysis, at a significance level of 5%.ResultsA total of 23 phyla, 257 genera and 425 species were detected. Firmicutes was the most abundant phylum in all samples. Three phyla (Fusobacteria, Synergistetes and unidentified_Bacteria) and seven genera (Fusobacterium, Porphyromonas, Phocaeicola, Olsenella, Campylobacter, Tannerella and Fretibacterium) were significantly more abundant in the symptomatic patients (p < .05), whereas asymptomatic patients had more Sphingomonas. The species more significantly abundant in the symptomatic samples were Porphyromonas gingivalis, Phocaeicola abscessus, Campylobacter showae, Tannerella forsythia and Olsenella uli (p < .05).ConclusionsA greater microbial diversity was observed in root filled teeth with PTAP compared to earlier reports. Several genera and species in root canal systems might be associated with clinical symptoms of PTAP.