bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape structure and suitable habitat analysis for effective restoration planning in semi-arid mountain forests
Authors: Piri Sahragard Hossein , Ajorlo Majid , Karami Peyman 
Published: March 2021

AbstractBackgroundSuitable habitat and landscape structure play a pivotal role in the success of forest restoration projects. This study aimed to model the habitat suitability of wild almond (Amygdalus scopariaSpach) using three individual species distribution models (SDMs), i.e., backpropagation artificial neural network (BP-ANN), maximum entropy (MaxEnt), generalized linear model (GLM), as well as the ensemble technique along with measuring the landscape metrics and analyzing the relationship between the distribution of the suitable habitat of the species in different landform classes in Fars Province, southern Iran.ResultsThere was no clear difference in the prediction performance of the models. The BP-ANN had the highest accuracy (AUC = 0.935 andk= 0.757) in modeling habitat suitability ofA. scoparia, followed by the ensemble technique, GLM, and MaxEnt models with the AUC values of 0.890, 0.887, and 0.777, respectively. The highest discrimination capacity was associated to the BP-ANN model, and the highest reliability was related to the ensemble technique. Moreover, evaluation of variable importance showed that the occurrence ofA. scopariawas strongly dependent on climatic variables, particularly isothermality (Bio 3), temperature seasonality (Bio 4), and precipitation of driest quarter (Bio 17). Analysis of the distribution of species habitat in different landform classes revealed that the canyon, mountain top, upland drainage, and hills in valley classes had the highest suitability for the species establishment.ConclusionsConsidering the importance of landform in the establishment of plant habitats, the combination of the outputs of the SDMs, landform, and the use of landscape metrics could provide both a clear view of habitat conditions and the possibility of analyzing habitat patches and their relationships that can be very useful in managing the remaining forests in semi-arid regions. The canyon, mountain top, and upland drainage classes were found to be the most important landforms to provide the highest suitable environmental conditions for the establishment ofA. scoparia. Therefore, such landforms should be given priority in restoration projects of forest in the study area.
Bridging the health inequality gap: an examination of South Africa’s social innovation in health landscape
Authors: de Villiers Katusha 
Published: March 2021

Abstract
Background
Despite the end of apartheid in the early 1990s, South Africa remains racially and economically segregated. The country is beset by persistent social inequality, poverty, unemployment, a heavy burden of disease and the inequitable quality of healthcare service provision. The South African health system is currently engaged in the complex project of establishing universal health coverage that ensures the system’s ability to deliver comprehensive care that is accessible, affordable and acceptable to patients and families, while acknowledging the significant pressures to which the system is subject. Within this framework, the Bertha Centre for Social Innovation & Entrepreneurship works to pursue social impact towards social justice in Africa with a systems lens on social innovation within innovative finance, health, education and youth development. The aim of this study is to demonstrate the capacity for social innovation in health with respect for South Africa, and to highlight some current innovations that respond to issues of health equity such as accessibility, affordability, and acceptability.

Methods
Different data types were collected to gain a rich understanding of the current context of social innovation in health within South Africa, supported by mini-case studies and examples from across the African continent, including: primary interviews, literature reviews, and organisational documentation reviews. Key stakeholders were identified, to provide the authors with an understanding of the context in which the innovations have been developed and implemented as well as the enablers and constraints. Stakeholders includes senior level managers, frontline health workers, Ministry of Health officials, and beneficiaries. A descriptive analysis strategy was adopted.

Results
South Africa’s health care system may be viewed, to a large extent, as a reflection of the issues facing other Southern African countries with a similar disease burden, lack of systemic infrastructure and cohesiveness, and societal inequalities. The evolving health landscape in South Africa and the reforms being undertaken to prepare for a National Healthcare Insurance presents the opportunity to understand effective models of care provision as developed in other African contexts, and to translate these models as appropriate to the South African environment.

Conclusions
After examining the cases of heath innovation, it is clear that no one actor, no matter how innovative, can change the system alone. The interaction and collaboration between the government and non-state actors is critical for an integrated and effective delivery system for both health and social care.
Melanopsin-mediated pupillary responses in bipolar disorder—a cross-sectional pupillometric investigation
Authors: Madsen Helle Østergaard , Ba-Ali Shakoor , Heegaard Steffen , Hageman Ida , Knorr Ulla , Lund-Andersen Henrik , Martiny Klaus , Kessing Lars Vedel 
Published: March 2021

Abstract
Background
Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses of these ganglion cells can be evaluated by pupillometry. The study aimed to assess the blue light induced pupil constriction in patients with bipolar disorder (BD).

Methods
We investigated the pupillary responses to blue light by chromatic pupillometry in 31 patients with newly diagnosed bipolar disorder, 22 of their unaffected relatives and 35 healthy controls. Mood state was evaluated by interview-based ratings of depressive symptoms (Hamilton Depression Rating Scale) and (hypo-)manic symptoms (Young Mania Rating Scale).

Results
The ipRGC-mediated pupillary responses did not differ across the three groups, but subgroup analyses showed that patients in remission had reduced ipRGC-mediated responses compared with controls (9%, p = 0.04). Longer illness duration was associated with more pronounced ipRGC-responses (7% increase/10-year illness duration, p = 0.02).

Conclusions
The ipRGC-mediated pupil response to blue light was reduced in euthymic patients compared with controls and increased with longer disease duration. Longitudinal studies are needed to corroborate these potential associations with illness state and/or progression.
Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment
Authors: Guo Rongqun , Lü Mengdie , Cao Fujiao , Wu Guanghua , Gao Fengcai , Pang Haili , Li Yadan , Zhang Yinyin , Xing Haizhou , Liang Chunyan , Lyu Tianxin , Du Chunyan , Li Yingmei , Guo Rong , Xie Xinsheng , Li Wei , Liu Delong , Song Yongping , Jiang Zhongxing 
Published: March 2021

AbstractBackgroundKnowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms of evading immune surveillance and immunotherapy response of targeting special microenvironment components.MethodsUsing a single-cell RNA sequencing (scRNA-seq) dataset, we analyzed the immune cell phenotypes, function, and developmental trajectory of bone marrow (BM) samples from 16 AML patients and 4 healthy donors, but not AML blasts.ResultsWe observed a significant difference between normal and AML BM immune cells. Here, we defined the diversity of dendritic cells (DC) and macrophages in different AML patients. We also identified several unique immune cell types including T helper cell 17 (TH17)-like intermediate population, cytotoxic CD4+T subset, T cell: erythrocyte complexes, activated regulatory T cells (Treg), and CD8+memory-like subset. Emerging AML cells remodels the BM immune microenvironment powerfully, leads to immunosuppression by accumulating exhausted/dysfunctional immune effectors, expending immune-activated types, and promoting the formation of suppressive subsets.ConclusionOur results provide a comprehensive AML BM immune cell census, which can help to select pinpoint targeted drug and predict efficacy of immunotherapy.
Neuronal hibernation following hippocampal demyelination
Authors: Baltan Selva , Jawaid Safdar S. , Chomyk Anthony M. , Kidd Grahame J. , Chen Jacqueline , Battapady Harsha D. , Chan Ricky , Dutta Ranjan , Trapp Bruce D. 
Published: March 2021

AbstractCognitive dysfunction occurs in greater than 50% of individuals with multiple sclerosis (MS). Hippocampal demyelination is a prominent feature of postmortem MS brains and hippocampal atrophy correlates with cognitive decline in MS patients. Cellular and molecular mechanisms responsible for neuronal dysfunction in demyelinated hippocampi are not fully understood. Here we investigate a mouse model of hippocampal demyelination where twelve weeks of treatment with the oligodendrocyte toxin, cuprizone, demyelinates over 90% of the hippocampus and causes decreased memory/learning. Long-term potentiation (LTP) of hippocampal CA1 pyramidal neurons is considered to be a major cellular readout of learning and memory in the mammalian brain. In acute slices, we establish that hippocampal demyelination abolishes LTP and excitatory post-synaptic potentials of CA1 neurons, while pre-synaptic function of Schaeffer collateral fibers is preserved. Demyelination also reduced Ca2+-mediated firing of hippocampal neurons in vivo. Using three-dimensional electron microscopy, we investigated the number, shape (mushroom, stubby, thin), and post-synaptic densities (PSDs) of dendritic spines that facilitate LTP. Hippocampal demyelination did not alter the number of dendritic spines. Surprisingly, dendritic spines appeared to be more mature in demyelinated hippocampi, with a significant increase in mushroom-shaped spines, more perforated PSDs, and more astrocyte participation in the tripartite synapse. RNA sequencing experiments identified 400 altered transcripts in demyelinated hippocampi. Gene transcripts that regulate myelination, synaptic signaling, astrocyte function, and innate immunity were altered in demyelinated hippocampi. Hippocampal remyelination rescued synaptic transmission, LTP, and the majority of gene transcript changes. We establish that CA1 neurons projecting demyelinated axons silence their dendritic spines and hibernate in a state that may protect the demyelinated axon and facilitates functional recovery following remyelination.
Strengthening multisectoral coordination on antimicrobial resistance: a landscape analysis of efforts in 11 countries
Authors: Joshi Mohan P. , Hafner Tamara , Twesigye Gloria , Ndiaye Antoine , Kiggundu Reuben , Mekonnen Negussu , Kusu Ndinda , Berthé Safoura , Lusaya Edgar Peter , Acho Alphonse , Tuala Robert Tuala , Siddiqua Ayasha , Kaboré Henri , Aidara Soukeyna Sadiya , Guzman Javier 
Published: March 2021

Abstract
Background
Increasingly, there has been recognition that siloed approaches focusing mainly on human health are ineffective for global antimicrobial resistance (AMR) containment efforts. The inherent complexities of AMR containment warrant a coordinated multisectoral approach. However, how to institutionalize a country’s multisectoral coordination across sectors and between departments used to working in silos is an ongoing challenge. This paper describes the technical approach used by a donor-funded program to strengthen multisectoral coordination on AMR in 11 countries as part of their efforts to advance the objectives of the Global Health Security Agenda and discusses some of the challenges and lessons learned.

Methods
The program conducted a rapid situational analysis of the Global Health Security Agenda and AMR landscape in each country and worked with the governments to identify the gaps, priorities, and potential activities in multisectoral coordination on AMR. Using the World Health Organization (WHO) Joint External Evaluation tool and the WHO Benchmarks for International Health Regulations (2005) Capacities as principal guidance, we worked with countries to achieve key milestones in enhancing effective multisectoral coordination on AMR.

Results
The program’s interventions led to the achievement of key benchmarks recommended actions, including the finalization of national action plans on AMR and tools to guide their implementation; strengthening the leadership, governance, and oversight capabilities of multisectoral governance structures; establishing and improving the functions of technical working groups on infection prevention and control and antimicrobial stewardship; and coordinating AMR activities within and across sectors.

Conclusion
A lot of learning still needs to be done to identify best practices for building mutual trust and adequately balancing the priorities of individual ministries with cross-cutting issues. Nevertheless, this paper provides some practical ideas for countries and implementing partners seeking to improve multisectoral coordination on AMR. It also demonstrates that the WHO benchmark actions, although not intended as an exhaustive list of recommendations, provide adequate guidance for increasing countries’ capacity for effective multisectoral coordination on AMR in a standardized manner.
History taking and response to an adult diarrheal case among community drug retail outlets in Gondar town, north-west Ethiopia: a simulated-client survey
Authors: Wondimsigegn Dawit , Woldegerima Berhanemeskel , Taddese Asefa Adimasu 
Published: March 2021

AbstractBackgroundSelf-care is one of the growing tasks of community pharmacy professionals. They are highly engaged in consultations in response to specific drug request (product-based presentation) or symptoms clients describe (symptom-based presentation).PurposeThis study was aimed at assessing the appropriateness of patient assessment and response to an adult diarrheal case among community drug retail outlets in Gondar town, north-west Ethiopia.MethodsA descriptive cross-sectional study design based on simulated-client method of visit was conducted from 03 August to 21 September, 2020. An adult female diarrheal case scenario was developed and used to guide data collectors to interact with professionals in a standardized and consistent way. All 60 dispensaries in the town during the data collection were included in the study. A pretested data collection tool was used to record the conversation between simulated clients and providers. The data were analyzed using SPSS version 20.ResultsWith regard to patient history, age of the patient, whether diarrhea is watery or bloody and onset and duration of diarrhea were the three most commonly requested questions with 59 (98.3%), 55 (91.7%) and 46 (76.7%), respectively. Past-medical and medication history are enquired in none of the visits. Medication was dispensed in 57 (95%) of the visits and no referral to a health facility was recommended in majority (90%) of cases. The most commonly recommended medications were ciprofloxacin 30 (52.6%) and metronidazole 20 (35.1%). ORS was considered in only 6 (10.5%) dispensaries.ConclusionPatient assessment, final decisions and treatment recommendations for an adult diarrheal case are inadequate, irrational and illegal. Educational interventions coupled with incentive mechanisms for cognitive pharmaceutical service and strict regulatory enforcement are needed to reduce the problem.
Soil-vegetation relationships in Mediterranean forests after fire
Authors: Fernández-García Víctor , Marcos Elena , Huerta Sara , Calvo Leonor 
Published: March 2021

AbstractBackgroundWildfires are one of the major environmental concerns in Mediterranean ecosystems. Thus, many studies have addressed wildfire impacts on soil and vegetation in Mediterranean forests, but the linkages between these ecosystem compartments after fire are not well understood. The aim of this work is to analyze soil-vegetation relationships in Mediterranean burned forests as well as the consistency of these relationships among forests with different environmental conditions, at different times after fire, and among vegetation with different functional traits.ResultsOur results indicate that study site conditions play an important role in mediating soil-vegetation relationships. Likewise, we found that the nature of soil-vegetation relationships may vary over time as fire effects are less dominant in both ecosystem compartments. Despite this, we detected several common soil-vegetation relationships among study sites and times after fire. For instance, our results revealed that available P content and stoichiometry (C:P and N:P) were closely linked to vegetation growth, and particularly to the growth of trees. We found that enzymatic activities and microbial biomass were inversely related to vegetation growth rates, whereas the specific activities of soil enzymes were higher in the areas with more vegetation height and cover. Likewise, our results suggest that resprouters may influence soil properties more than seeders, the growth of seeders being more dependent on soil status.ConclusionsWe provide pioneer insights into how vegetation is influenced by soil, and vice-versa, in Mediterranean burned areas. Our results reflect variability in soil-vegetation relationships among study sites and time after fire, but consistent patterns between soil properties and vegetation were also detected. Our research is highly relevant to advance in forest science and could be useful to achieve efficient post-fire management.
Effectiveness of protocol-based pharmacotherapy management collaboration between hospital and community pharmacists to address capecitabine-related hand–foot syndrome in cancer patients: a retrospective study
Authors: Nakamura Nobuhiko , Shiraiwa Hiroki , Haruna Yasuhiro , Ichijima Tomoki , Takeda Tomoko , Hasegawa Koji , Kusumoto Masaaki , Yano Yoshitaka 
Published: March 2021

Abstract
Background
Pharmaceutical care of capecitabine-related hand–foot syndrome (HFS) is extremely important to avoid the progression of the syndrome. Protocol-based pharmacotherapy management (PBPM) of HFS by community pharmacists has been introduced in our community, whereby the community pharmacist instructs patients to use steroid creams if they develop HFS of grade 2 or higher. This study aimed to evaluate the effectiveness of PBPM in cancer patients with HFS by comparing it to conventional pharmaceutical care using monitoring reports for pharmacotherapy management by community pharmacists.

Methods
From September 2017 to August 2019, we retrospectively investigated the medical records of 396 cancer patients who received capecitabine adjuvant chemotherapy. Before PBPM implementation, conventional pharmaceutical care was administered from September 2017 to August 2018; these patients served as the control group. Care was switched to PBPM in September 2018, and PBPM was applied from September 2018 to August 2019; these patients served as the PBPM group. We excluded patients who received both conventional pharmaceutical care and PBPM. We categorized all cases into two groups: age ≤ 69 years and age ≥ 70 years.

Results
In all, 396 cases were included, of which 227 were ineligible, such as those of cancer patients who received both conventional pharmaceutical care and PBPM. Among patients aged higher than 70 years, the incidence and severity of HFS associated with PBPM were significantly lower than those associated with conventional care (grade 0: 59.5% [44/74] vs. 30.6% [11/36], grade 1: 33.8% [25/74] vs. 63.9% [23/36]). All patients continued to receive the capecitabine, HFS severity improved to grade 1 during the study period, and treatment of HFS was not stopped.

Conclusion
Our findings suggest that PBPM is effective for addressing capecitabine-related HFS among cancer patients aged higher than 70 years, in that it helps prevent an increase in HFS severity.
Darwinian Selection Discriminates Young Athletes: the Relative Age Effect in Relation to Sporting Performance
Authors: Jakobsson Johan , Julin A. Lennart , Persson Glenn , Malm Christer 
Published: March 2021

Abstract
Background
The relative age effect (RAE) is a worldwide phenomenon, allowing sport participation and elite selection to be based on birthdate distribution. Negative consequences include both a narrow, non-optimal elite selection and negative health effects on entire populations. This study investigated the RAE and athletic performance in multiple individual sports in Sweden.

Methods
Birthdates of athletes born between the years 1922 and 2015 were collected across 4-month periods (tertiles: T1, T2, T3) from cross-country skiing (N = 136,387), orienteering (N = 41,164), athletics (N = 14,503), alpine skiing (N = 508), E-sports (N = 47,030), and chess (N = 4889). In total, data from 244,560 athletes (women: N = 79,807, men: N = 164,753) was compared to the complete parent population of 5,390,954 births in Sweden during the same years. Chi-squared statistics compared parent and cohort distributions stratified by sport, sex, and age.

Results
A significantly skewed distribution of birthdates was present in all sports, both sexes, and most age groups. The largest RAEs are seen in children where T1 often constitutes 40–50% and T3, 20–25% of the population. In E-sports, an inversed RAE was seen in adults. In most investigated sports, birthdate distribution was correlated to performance in children but not in adults.

Conclusions
Skewed birthdate distributions were consistently prevalent in all investigated individual sports in Sweden, both physically demanding and cognitive/skill-based. As sport participation is related to total level of physical activity, both present and future, failing to address the RAE issue at an early age will result not only in a narrow and arbitrary selection for adult elite athletes but also in a negative impact on public health.