bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Extended Foundation of the Caribbean Court of Justice between Decolonisation and Globalisation
Authors: Caserta Salvatore 
Published: March 2021

Abstract
This chapter deals with the extended process of creation of the Caribbean Court of Justice (CCJ) arguing that, different from what often stated in the literature, the Court is the institutional crystallisation of two long-enduring movements within the Caribbean legal field. One of these two movements is linked to the development of early regionalism, and ties into the Court’s origins as a regional economic institution aimed at reviving the Caribbean Common Market (CARICOM). The other is a movement related to the long-lasting process of Caribbean decolonisation from the United Kingdom, as the CCJ is also intended to be a regional Supreme Court to replace the Privy Council as the apex court of the former British West Indian colonies. The chapter also analyses the window of opportunity leading to the creation of the Court, most notably the clash between different generations of Caribbean legal elites and their own respective disagreements with the Judicial Committee of the Privy Council on death penalty issues and, more generally, on how to handle the judicial system of the Caribbean countries.
The Efficacy of Hyaluronic Acid for Carpal Tunnel Syndrome: A Randomized Double-Blind Clinical Trial
Authors: Su Yu-Chi , Shen Yu-Ping , Li Tsung-Ying , Ho Tsung-Yen , Chen Liang-Cheng , Wu Yung-Tsan 
Published: March 2021

Abstract

Objectives
To investigate the effect of hyaluronic acid (HA) in patients diagnosed with mild or moderate carpal tunnel syndrome (CTS).

Design
A prospective randomized, double-blinded control study with 6 months of follow-up.

Setting
Rehabilitation outpatient clinic of one single medical center.

Subjects
Thirty-five participants with mild or moderate CTS.

Methods
Participants were enrolled and randomly assigned to HA or control groups. The HA group received one ultrasound-guided perineural injection of 2.5 mL HA while the control group received 2.5 mL normal saline injection through in-plane, long-axis approach to separate the median nerve from the flexor retinaculum via nerve hydrodissection. Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) scores were the primary outcome, while secondary outcomes included the numeric rating scale (NRS), electrophysiological domains, and the cross-sectional area of the median nerve. The assessment was conducted prior to injection and during the second week and 1-, 3-, and 6-months post-injection.

Results
Thirty-two patients (17 wrists in HA group and 15 wrists in control group) completed the study. Compared with the control group, the HA group did not show significantly superior outcomes, except in BCTQ and NRS at the second week post-injection (all P &lt; .0125).

Conclusions
A single ultrasound guided perineural HA injection may have short-term therapeutic efficacy for mild or moderate CTS; however, the 2-weeks superior efficacy was not beneficial for chronic neuropathy. Further studies with larger sample sizes are required to verify its therapeutic efficacy.
Social trauma as a contributory factor in Filipino’s vaccine hesitancy
Authors: Vergara Raymond John D 
Published: March 2021

Abstract
Despite of the Government’s effort to persuade the public to participate in its vaccination program against COVID-19, vaccine hesitancy remains to be a big challenge in the Philippines. While various efforts were undertaken to promote the safety and efficacy of vaccines against COVID-19, it is imperative that the Philippine government considers social traumas as a factor in vaccine hesitancy. This study proposes Judith Herman’s stages of trauma recovery as a possible framework that could be utilize by the government in its drive to increase public trust.
The role of trimethoprim/sulfametoxazole in reducing relapses and risk of infections in ANCA-associated vasculitis: a meta-analysis
Authors: Monti Sara , Delvino Paolo , Riboli Mattia , Rebuffi Chiara , Xoxi Blerina , De Silvestri Annalisa , Montecucco Carlomaurizio 
Published: March 2021

Abstract

Objectives
To assess available evidence from randomized controlled trials (RCTs) and observational studies including a control group regarding the role of trimethoprim/sulfametoxazole (TMP/SMX) in reducing the relapse rate in patients with granulomatosis with polyangiitis (GPA) and the risk of infections in patients with ANCA-associated vasculitis (AAV).

Methods
MEDLINE, EMBASE, The Cochrane Library databases, Scopus, Web of Science and ClinicalTrials.gov were searched from inception until 15 January 2020 to identify controlled studies assessing the role of TMP/SMX in reducing the rate of relapse in patients with GPA (primary outcome) and the number and/or severity of infections in patients with AAV (secondary outcome). Two reviewers independently selected eligible studies and extracted data. Cumulative risk ratios (RRs) with 95% CI were calculated using a random effect meta-analysis.

Results
Eight studies were selected out of 2907 records. Seven studies (520 patients) (of which two were RCTs) assessed the role of TMP/SMX in the relapse rate in patients with GPA. TMP/SMX was not associated with a reduced risk of relapse (RR = 1.15, 95% CI: 0.51, 2.55; I2 = 78.5%; P &lt; 0.001). Sensitivity analysis according to the dose of TMP/SMX (960 mg twice daily vs three times/week) confirmed the results. One retrospective cohort study (192 patients) was identified demonstrating a significant reduction of severe infections in patients with AAV receiving prophylaxis with TMP/SMX in association with rituximab.

Conclusion
TMP/SMX was not associated with a reduced risk of relapse in patients with GPA. TMP/SMX might be useful in the reduction of infectious complications.

Prospero database registration code
CRD42019118983.
Risk of venous thromboembolism associated with tofacitinib in patients with rheumatoid arthritis: a population-based cohort study
Authors: Desai Rishi J , Pawar Ajinkya , Khosrow-Khavar Farzin , Weinblatt Michael E , Kim Seoyoung C 
Published: March 2021

AbstractObjectiveTo evaluate the risk of venous thromboembolism (VTE) with tofacitinib compared with TNFis in patients with RA.MethodsRA patients initiating tofacitinib or a TNFi without use of any biologic or tofacitinib any time prior were identified from IBM ‘MarketScan’ (2012–18), Medicare (parts A, B and D, 2012–17) or ‘Optum’ Clinformatics (2012–19) and followed until treatment discontinuation, treatment switch, insurance disenrollment or administrative censoring. The primary outcome, VTE, was identified using inpatient claims for pulmonary embolism or deep vein thrombosis. A Cox proportional hazards model provided hazard ratio (HR) and 95% CIs after accounting for confounding through propensity score fine-stratification weighting. HRs were pooled across databases with inverse variance meta-analytic method.ResultsA total of 42 201, 25 078 and 20 374 RA patients were identified from MarketScan, Medicare and Optum, respectively, of whom 7.1, 7.1 and 9.7% were tofacitinib initiators. The crude incidence rates per 100 person-years (95% CI) were 0.42 (0.20–0.77) and 0.35 (0.29–0.42) in MarketScan, 1.18 (0.68–1.92) and 0.83 (0.71–0.97) in Medicare, and 0.19 (0.04–0.57) and 0.34 (0.26–0.44) in Optum for tofacitinib and TNFis, respectively. Propensity score-weighted HRs showed no significant differences in the risk of VTE between tofacitinib and TNFis in any database with a pooled HR (95% CI) of 1.13 (0.77–1.65).ConclusionOverall, VTE occurred infrequently (&lt;1 per 100) in a total of 87 653 RA patients initiating tofacitinib or a TNFi. We observed no evidence for an increased risk of VTE for tofacitinib vs TNFis in RA patients.
On Defining and Finding Islands of Trees and Mitigating Large Island Bias
Authors: Silva Ana Serra , Wilkinson Mark 
Published: March 2021

Abstract
How best can we summarize sets of phylogenetic trees? Systematists have relied heavily on consensus methods, but if tree distributions can be partitioned into distinct subsets, it may be helpful to provide separate summaries of these rather than relying entirely upon a single consensus tree. How sets of trees can most helpfully be partitioned and represented leads to many open questions, but one natural partitioning is provided by the islands of trees found during tree searches. Islands that are of dissimilar size have been shown to yield majority-rule consensus trees dominated by the largest sets We illustrate this large island bias and approaches that mitigate its impact by revisiting a recent analysis of phylogenetic relationships of living and fossil amphibians. We introduce a revised definition of tree islands based on any tree-to-tree pairwise distance metric that usefully extends the notion to any set or multiset of trees, as might be produced by, for example, Bayesian or bootstrap methods, and that facilitates finding tree islands a posteriori. We extract islands from a tree distribution obtained in a Bayesian analysis of the amphibian data to investigate their impact in that context, and we compare the partitioning produced by tree islands with those resulting from some alternative approaches. Distinct subsets of trees, such as tree islands, should be of interest because of what they may reveal about evolution and/or our attempts to understand it, and are an important, sometimes overlooked, consideration when building and interpreting consensus trees. [Amphibia; Bayesian inference; consensus; parsimony; partitions; phylogeny; Chinlestegophis.]
Evaluation of nitrogen-delivery methods for stocker cattle grazing annual ryegrass
Authors: Gunter Phillip A , Mullenix Mary K , Burdette Lance C , Muntifering Russell B 
Published: March 2021

Abstract
A 2-yr grazing experiment was conducted to evaluate efficacy of nitrogen (N) fertilization, interseeded legumes, and protein supplementation for N delivery to stocker cattle grazing annual ryegrass (Lolium multiflorum). Each year, 90 steers (initial BW, 241 ± 13 kg) were assigned to the following N-delivery methods, with or without monensin fed in a free-choice mineral supplement as a 5 × 2 factorial arrangement of treatments: ryegrass fertilized with 112 kg N/ha (NFERT); ryegrass interseeded with crimson clover (CC, Trifolium incarnatum); ryegrass interseeded with arrowleaf clover (AC, Trifolium vesiculosum); ryegrass plus distillers dried grains with solubles (DDGS) supplemented at 0.65% BW daily; and ryegrass plus whole cottonseed (WCS) supplemented at 0.65% BW daily. Pastures within the interseeded-clover and protein-supplementation treatments were fertilized with 56 kg N/ha at time of establishment. Steers were weighed every 28 d, and forage mass (FM, kg DM/ha) was measured concurrently using the destructive harvest/disk meter double-sampling method. Each of 30 0.81-ha paddocks was stocked initially with 3 “tester” steers, and stocking density (steers/ha) was adjusted using “put-and-take steers” based on changes in FM and steer BW in order to maintain a uniform forage allowance (FA) of 1 kg DM/kg steer BW. Grazing was discontinued on May 11, 2016 in Yr 1 and May 10, 2017 in Yr 2 following 140 and 84 d of grazing, respectively. Data were analyzed as a completely randomized design with repeated measures for which pasture (n = 3) was the experimental unit. Ionophore inclusion did not affect (P &gt; 0.10) any variable measured. Mean FM differed (P &lt; 0.0001) between years and among N-delivery methods (P &lt; 0.10), and mean FA differed (P = 0.005) among N-delivery methods. Steer ADG differed among N-delivery methods (P = 0.02) and between years (P &lt; 0.001), whereas total gain/ha differed (P &lt; 0.0008) among N-delivery methods, but not between years (P = 0.78). Stocking density differed among N-delivery methods (P = 0.02) and between years (P &lt; 0.0001), and grazing-days/ha differed between years (P &lt; 0.0001) and among N-delivery methods (P = 0.001). Results indicate that supplementation with a high-protein by-product feed for cattle grazing annual ryegrass maintained ADG, total gain/ha and grazing-days/ha compared with N-fertilized annual ryegrass, and increased ADG, total gain/ha, and grazing-days over interseeded legumes.
Sensitivity of Phytophthora capsici from Tennessee to Mefenoxam, Fluopicolide, Oxathiapiprolin, Dimethomorph, Mandipropamid, and Cyazofamid
Authors: Siegenthaler Timothy B. , Hansen Zachariah R. 
Published: March 2021

Phytophthora blight is a destructive disease caused by the oomycete Phytophthora capsici, which affects vegetable production throughout the state of Tennessee and worldwide. Fungicides are a primary control method used in managing Phytophthora blight, but in some cases the efficacy of these products has been reduced or lost in the field. In 2018 and 2019, the efficacy of six fungicides was tested in vitro on 184 P. capsici isolates collected in Tennessee using radial growth assays. The fungicides included in the study were mefenoxam, fluopicolide, oxathiapiprolin, dimethomorph, mandipropamid, and cyazofamid. Seven isolates were resistant to mefenoxam, 86 were resistant to fluopicolide, one was resistant to oxathiapiprolin, and 13 were resistant to cyazofamid. None were resistant to dimethomorph or mandipropamid. Of the 86 isolates resistant to fluopicolide, five were also resistant to mefenoxam. Resistance to fluopicolide and cyazofamid was widespread in Tennessee, and it was more localized for mefenoxam and oxathiapiprolin. The results of this study show that fungicide resistance is widespread in P. capsici in Tennessee, and the implications for Phytophthora blight management are discussed.
Wound Bed Preparation 2021
Authors: Sibbald R. Gary , Elliott James A. , Persaud-Jaimangal Reneeka , Goodman Laurie , Armstrong David G. , Harley Catherine , Coelho Sunita , Xi Nancy , Evans Robyn , Mayer Dieter O. , Zhao Xiu , Heil Jolene , Kotru Bharat , Delmore Barbara , LeBlanc Kimberly , Ayello Elizabeth A. , Smart Hiske , Tariq Gulnaz , Alavi Afsaneh , Somayaji Ranjani 
Published: March 2021

ABSTRACT
Wound Bed Preparation is a paradigm to optimize chronic wound treatment. This holistic approach examines the treatment of the cause and patient-centered concerns to determine if a wound is healable, a maintenance wound, or nonhealable (palliative). For healable wounds (with adequate blood supply and a cause that can be corrected), moisture balance is indicated along with active debridement and control of local infection or abnormal inflammation. In maintenance and nonhealable wounds, the emphasis changes to patient comfort, relieving pain, controlling odor, preventing infection by decreasing bacteria on the wound surface, conservative debridement of slough, and moisture management including exudate control. In this fourth revision, the authors have reformulated the model into 10 statements. This article will focus on the literature in the last 5 years or new interpretations of older literature. This process is designed to facilitate knowledge translation in the clinical setting and improve patient outcomes at a lower cost to the healthcare system.

GENERAL PURPOSE
To present the 2021 update of the Wound Bed Preparation paradigm.

TARGET AUDIENCE
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES
After participating in this educational activity, the participant will: 1. Apply wound assessment strategies. 2. Identify patient concerns about wound care. 3. Select management options for healable, nonhealable, and maintenance wounds.
Human Amnion Chorion Membrane Allografts in the Treatment of Chronic Diabetic Foot Ulcers: A Literature Review
Authors: Oropallo Alisha , Goodwin Ashley , Morrissey MaKenzie , Del Pin Christina , Rao Amit 
Published: March 2021

ABSTRACT

OBJECTIVE
To discuss human amnion chorion (placental) membrane allograft (HACMA) use for the treatment of chronic diabetic foot ulcers (DFUs) and to evaluate the effectiveness, cost, and product waste of this therapy.

DATA SOURCES
PubMed, Cochrane, and OVID databases.

STUDY SELECTION
Twenty-four articles pertaining to HACMA and DFUs published from 2016 to 2020 were selected.

DATA EXTRACTION
The data collected included type of wound care product, study design, study size, baseline size of DFU, cost, product wastage, number of applications, and wound healing outcomes.

DATA SYNTHESIS
Human amnion chorion membrane allografts in the treatment of chronic DFUs have led to a reduction in healing time and increased the overall percentage of healing, making them more effective in treating DFUs compared with standard of care. These products are offered in multiple sizes with various shelf lives and methods of storage, making them accessible, easy to use, less wasteful, and lower in cost compared with other commercially available products. Promising evidence demonstrates that HACMAs are beneficial in treating complex, high-grade DFUs with exposed tendon or bone.

CONCLUSIONS
Human amnion chorion membrane allografts are effective in treating chronic DFUs with a greater percentage of complete wound closure and a reduction in healing time versus standard of care.
Diverse Treatments for Deep Burn Wounds: A Case Report
Authors: Zhou Ling , Liu Chunmei , Luo Yimei , Xiang Fei , Song Huapei 
Published: March 2021

ABSTRACT
Patients with extensive deep burns usually experience infections and organ dysfunction. Proactive and effective wound repair is key to treatment. If large wounds remain open, systemic infection and multiple organ dysfunction syndrome can occur, threatening the lives of patients. Current wound repair methods include skin grafts, flap repair, negative-pressure wound therapy, and cellular and/or tissue-based products. For deep, complex burn wounds, a single form of treatment is usually ineffective.
This article reports a rare case of burn wound repair. The patient was burned by a charcoal flame on multiple parts of his body after carbon monoxide poisoning. Pneumothorax and acute renal failure occurred after the injury, accompanied by multiple osteonecroses of the trunk and lower limbs. A multidisciplinary team formulated an individualized treatment plan; the diverse treatments included closed chest drainage, continuous renal replacement therapy, infection control, analgesia, wound debridement, negative-pressure wound therapy, cellular and/or tissue-based products, autologous dermal scaffold graft, skin grafts, flap transposition, platelet-rich plasma, and rehabilitation, which ultimately saved the patient’s life and led to healing of all the wounds.
Pharmacogenetic testing
Authors: Fredrikson Karin M. , Fasolino Tracy 
Published: March 2021

Abstract:
NPs commonly prescribe pharmaceutical therapies such as opiates, antidepressants, and/or other analgesics to improve the health and well-being of patients experiencing chronic pain. This article provides NPs with pharmacogenetic testing knowledge, such as readiness for clinical implementation, considerations for choosing a testing service, and testing costs for chronic pain management.
Posterior Quadratus Lumborum Block in Total Hip Arthroplasty: A Randomized Controlled Trial
Authors: Brixel Sophia Margareta , Biboulet Philippe , Swisser Fabien , Choquet Olivier , Aarab Yassir , Nguyen Helen , Bringuier Sophie , Capdevila Xavier 
Published: March 2021

Background
Pain management is important for ensuring early mobilization after hip arthroplasty; however, the optimal components remain controversial. Recently, the quadratus lumborum block has been proposed as an analgesic option. The current study tested the hypothesis that the posterior quadratus lumborum block combined with multimodal analgesia decreases morphine consumption after hip arthroplasty.

Methods
This study was a prospective, randomized, double-blind, placebo-controlled trial. Before general anesthesia, 100 participating patients scheduled for elective total hip arthroplasty were randomly allocated to receive a 30-ml injection posterior to the quadratus lumborum muscle with either 0.33% ropivacaine (n = 50) or normal saline (n = 50). For all patients, multimodal analgesia included systematic administration of acetaminophen, ketoprofen, and a morphine intravenous patient-controlled analgesia. The primary outcome was total intravenous morphine consumption in the first 24 h. Secondary outcomes recorded intraoperative sufentanil consumption; morphine consumption in the postanesthesia care unit; pain scores at extubation and at 2, 6, 12, and 24 h; motor blockade; time to first standing and ambulation; hospital length of stay; and adverse events.

Results
There was no significant difference in the 24-h total morphine consumption (ropivacaine group, median [interquartile range], 13 [7 to 21] versus saline group, 16 [9 to 21] mg; median difference, −1.5; 95% CI, −5 to 2; P = 0.337). Pain scores were not different between the groups (β = −0.4; 95% CI, −0.9 to 0.2; P = 0.199). There was no statistical difference between the two groups in intraoperative sufentanil consumption, morphine consumption in the postanesthesia care unit, motor blockade, times to first standing (median difference, 0.83 h; 95% CI, −1.7 to 3.4; P = 0.690) and ambulation (median difference, −1.85 h; 95% CI, −4.5 to 0.8; P = 0.173), hospital length of stay, and adverse events.

Conclusions
After elective hip arthroplasty, neither morphine consumption nor pain scores were reduced by the addition of a posterior quadratus lumborum block to a multimodal analgesia regimen.

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New
Compounded bioidentical hormone therapy: new recommendations from the 2020 National Academies of Sciences, Engineering, and Medicine
Authors: Stuenkel Cynthia A. 
Published: March 2021

Abstract
Bioidentical hormones have the exact same chemical and molecular structure as hormones that are produced in the human body. Bioidentical hormones are available as FDA-approved hormone formulations. Nonapproved custom-compounded preparations are marketed as bioidentical, but content is uncertain. The widespread use of compounded bioidentical hormone therapy despite the lack of evidence to support its safety and efficacy is concerning. This Practice Pearl highlights the 2020 recommendations from the National Academies of Sciences, Engineering, and Medicine regarding the use of compounded bioidentical hormones.