bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tocharian B agent nouns in -ntsa and their origin
Authors: Friis Louise S. 
Published: November 2021

Abstract
The agent noun suffix in -ntsa belongs to a complex of Tocharian B agent noun formations, similar in form, function, and inflection. Of these, two suffixes are widely believed to be related to -ntsa: the productive agent noun in -ñca and the lexicalised agent noun in -nta. The suffix -ntsa forms occupational titles to eleven verbs in Tocharian B and can be reconstructed for Proto-Tocharian through comparison with Tocharian A. In this paper, it is argued that the suffix originated in the feminine of the PIE active participle in *-nt. This is substantiated by the fact that several ntsa-nouns refer to primarily female professions, as well as the existence of the relic forms Bpreṃtsa ‘pregnant’ and Blāntsa ‘queen’. Furthermore, it is proposed that the masculine is reflected in the suffixes -ñca and -nta and that the disintegration of gendered inflection in the participle led to its development into several agent noun formations.
Indo-Pacific Warming Induced by a Weakening of the Atlantic Meridional Overturning Circulation
Authors: Sun Shantong , Thompson Andrew F. , Xie Shang-Ping , Long Shang-Min 
Published: November 2021

Abstract
The reorganization of the Atlantic meridional overturning circulation (AMOC) is often associated with changes in Earth’s climate. These AMOC changes are communicated to the Indo-Pacific basins via wave processes and induce an overturning circulation anomaly that opposes the Atlantic changes on decadal to centennial time scales. We examine the role of this transient, interbasin overturning response, driven by an AMOC weakening, both in an ocean-only model with idealized geometry and in a coupled CO2 quadrupling experiment, in which the ocean warms on two distinct time scales: a fast decadal surface warming and a slow centennial subsurface warming. We show that the transient interbasin overturning produces a zonal heat redistribution between the Atlantic and Indo-Pacific basins. Following a weakened AMOC, an anomalous northward heat transport emerges in the Indo-Pacific, which substantially compensates for the Atlantic southward heat transport anomaly. This zonal heat redistribution manifests as a thermal interbasin seesaw between the high-latitude North Atlantic and the subsurface Indo-Pacific and helps to explain why Antarctic temperature records generally show more gradual changes than the Northern Hemisphere during the last glacial period. In the coupled CO2 quadrupling experiment, we find that the interbasin heat transport due to a weakened AMOC contributes substantially to the slow centennial subsurface warming in the Indo-Pacific, accounting for more than half of the heat content increase and sea level rise. Thus, our results suggest that the transient interbasin overturning circulation is a key component of the global ocean heat budget in a changing climate.
Break Events of the Western North Pacific Summer Monsoon during 1979–2018
Authors: Xu Ke , Lu Riyu 
Published: November 2021

Abstract
The monsoon break is a typical phenomenon representing the monsoon’s subseasonal variability, but our understanding of it is still limited for the western North Pacific (WNP) area. This study identifies all break events of the WNP summer monsoon (WNPSM) from 1979 to 2018. The statistical analysis suggests that break events occur from late June to late October and peak at the end of August. The occurrence frequency of break events decreases as the duration increases, with 74% of events persisting for 3–7 days and merely 26% lasting longer (8–15 days). During the break period, which is characterized by significant suppression of convection, there is an extensive anticyclonic anomaly in the lower troposphere, corresponding to a notable westward retreat of the monsoon trough and a southwestward shift of the subtropical high. Meanwhile, an anomalous cyclone and convergence in the upper troposphere are also conducive to inhibiting convection. The composite results indicate that both 10–25- and 30–60-day oscillations contribute to the break, with their dry phases explaining 49.6% and 37.5% of the original suppression of convection, respectively. Around the break, the phase alternation of the 10–25-day oscillation causes convection fluctuation, while the 30–60-day oscillation maintains a stable dry phase that favors the establishment and maintenance of the break. A further case-by-case diagnosis suggests that 46 (51) out of the 61 break events occur in dry phases of the 10–25-day (30–60-day) oscillation, whereas only 10 (4) events occur in wet phases, indicating that the phase of the two oscillations significantly modulates the occurrence of the monsoon break.
Preventive antibiotic therapy in acute stroke patients: A systematic review and meta-analysis of individual patient data of randomized controlled trials
Authors: Westendorp Willeke F , Vermeij Jan-Dirk , Smith Craig J , Kishore Amit K , Hodsoll John , Kalra Lalit , Meisel Andreas , Chamorro Angel , Chang Jason J , Rezaei Yousef , Amiri-Nikpour Mohammad R , DeFalco Fabrizio A , Switzer Jeffrey A , Blacker David J , Dijkgraaf Marcel GW , Nederkoorn Paul J , van de Beek Diederik 
Published: November 2021

Introduction Infection after stroke is associated with unfavorable outcome. Randomized controlled studies did not show benefit of preventive antibiotics in stroke but lacked power for subgroup analyses. Aim of this study is to assess whether preventive antibiotic therapy after stroke improves functional outcome for specific patient groups in an individual patient data meta-analysis. Patients and methods We searched MEDLINE (1946–7 May 2021), Embase (1947–7 May 2021), CENTRAL (17th September 2021), trial registries, cross-checked references and contacted researchers for randomized controlled trials of preventive antibiotic therapy versus placebo or standard care in ischemic or hemorrhagic stroke patients. Meta-analysis was performed by a one-step and two-step approach. Primary outcome was functional outcome adjusted for age and stroke severity. Secondary outcomes were infections and mortality. Results 4197 patients from nine trials were included. Preventive antibiotic therapy was not associated with a shift in functional outcome (mRS) at 3 months (OR1.13, 95%CI 0.98–1.31) or unfavorable functional outcome (mRS 3–6) (OR0.85, 95%CI 0.60–1.19). Preventive antibiotics did not improve functional outcome in pre-defined subgroups (age, stroke severity, timing and type of antibiotic therapy, pneumonia prediction scores, dysphagia, type of stroke, and type of trial). Preventive antibiotics reduced infections (276/2066 (13.4%) in the preventive antibiotic group vs. 417/2059 (20.3%) in the control group, OR 0.60, 95% CI 0.51–0.71, p < 0.001), but not pneumonia (191/2066 (9.2%) in the preventive antibiotic group vs. 205/2061 (9.9%) in the control group (OR 0.92 (0.75–1.14), p = 0.450). Discussion and conclusion Preventive antibiotic therapy did not benefit any subgroup of patients with acute stroke and currently cannot be recommended.
Cytotoxic, apoptotic, and genetic evaluations of Nigella sativa essential oil nanoemulsion against human hepatocellular carcinoma cell lines
Authors: Abd-Rabou Ahmed A. , Edris Amr E. 
Published: November 2021

Abstract
Background
Phytochemicals and plant extracts are showing promising anticancer potentials. In the current study, the volatile faction (essential oil) of Nigella sativa seeds was evaluated against some hepatocellular carcinoma (HCC). The essential oil was extracted and characterized by chromatographic techniques to reveal its chemical composition, especially thymoquinone. Then, the oil was fabricated in two nanoemulsion formulations (F1 and F2), which differ in their composition of surfactants. The cytotoxicity and apoptotic activities of the essential oil and its nanoemulsions were evaluated in vitro against HepG2 and Huh-7 cell lines. Normal WI-38 cell line was also included in that evaluation to study the selectivity and safety of the different formulations on normal cells.

Results
Gas chromatographic analysis indicated that the essential oil is composed mainly of p-cymene (40.0%), thymoquinone (31.2%) and trans-α-thujene (12.8%). Particle size of the nanoemulsions ranged between 9.4 and 119.7 nm depending on the type of surfactant used in the formulation process. The pure essential oil and its two nanoemulsions (F1 and F2) showed dose-dependent antiproliferative activity against both HCC cells. This activity reached its highest cell inhibition in the case of nanoemulsion (F2) where the proliferation percentage was only 21.9% and 9.2% against HepG2 and Huh-7 cells, respectively. The same nanoemulsion (F2) also showed the lowest IC50 values (55.7 and 35.5 µg/ml) against both HepG2 and Huh-7 cells, respectively, compared to 100 µg/ml for the reference drug Doxorubicin. Flow cytometric analysis also confirmed that nanoemulsion (F2) has the highest apoptotic activity compared to nanoemulsion (F1) and the pure unformulated essential oil. Genetic expressions of pro-apoptotic (Bax) and the anti-apoptotic (Bcl-2) gene markers evaluation revealed that nanoemulsion (F2) has better activity in upregulating (Bax) and down-regulate (Bcl-2) with the highest Bax/Bcl-2 ratio (69) was found against Huh-7 cells. All N. sativa nanoemulsions showed minimal cytotoxicity on the normal WI-38 cell, indicating wide safety margins due to selective properties.

Conclusion
Overall, the study revealed the potentials of N. sativa essential oil, after formulation in specially tailored nanoemulsion for application as potential adjuvant liver anticancer agent.

Graphical Abstract
Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson’s disease mouse model
Authors: Seo Min Hyung , Lim Sabina , Yeo Sujung 
Published: November 2021

Abstract
Background
Parkinson’s disease (PD) represent a loss of dopaminergic neurons in the substantia nigra (SN) of the midbrain. However, its cause remains unknown and Triadin (TRDN) function in the brain is also unknown. To examine the relationship between TRDN and PD, the expression levels of protein related to PD in TRDN knockdown status were studied in the SH-SY5Y cells. Cell viability and apoptosis were assessed to examine the apoptosis effect on dopaminergic cells by decreased TRDN, and the levels of the proteins related to apoptosis were also confirmed.

Results
This study confirmed decreased TRDN expression level (P < 0.005) at the SN in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model and identified the functional features of TRDN. Our results showed a relationship between TRDN expression and PD in that reduced TRDN level induced PD-like characteristics. Interestingly, there was TRDN expression in the regions where dopaminergic cells are in the SN, and the expression patterns of TRDN and tyrosine hydroxylase (TH) were similar. Decreased TRDN level also induced apoptotic characteristics and the Fluorescence-activated cell sorting analysis results showed that apoptosis increased (P < 0.05) as the TRDN small interfering RNA concentration increased. The cytotoxicity assay revealed that cell viability also decreased (P < 0.0005) in the same condition as that in the Fluorescence‐activated cell sorting analysis.

Conclusions
Decreased TRDN level could be related with the apoptotic death of dopaminergic cells at the SN in PD, and TRDN administration could give a positive effect on PD by reducing apoptotic cell death.
Comparative transcriptome analysis of coleorhiza development in japonica and Indica rice
Authors: Song Tao , Das Debatosh , Ye Neng-Hui , Wang Guan-Qun , Zhu Fu-Yuan , Chen Mo-Xian , Yang Feng , Zhang Jian-Hua 
Published: November 2021

Abstract
Background
Coleorhiza hairs, are sheath-like outgrowth organs in the seeds of Poaceae family that look like root hair but develop from the coleorhiza epidermal cells during seed imbibition. The major role of coleorhiza hair in seed germination involves facilitating water uptake and nutrient supply for seed germination. However, molecular basis of coleorhiza hair development and underlying genes and metabolic pathways during seed germination are largely unknown and need to be established.

Results
In this study, a comparative transcriptome analysis of coleorhiza hairs from japonica and indica rice suggested that DEGs in embryo samples from seeds with embryo in air (EIA) as compared to embryo from seeds completely covered by water (CBW) were enriched in water deprivation, abscisic acid (ABA) and auxin metabolism, carbohydrate catabolism and phosphorus metabolism in coleorhiza hairs in both cultivars. Up-regulation of key metabolic genes in ABA, auxin and dehydrin and aquaporin genes may help maintain the basic development of coleorhiza hair in japonica and indica in EIA samples during both early and late stages. Additionally, DEGs involved in glutathione metabolism and carbon metabolism are upregulated while DEGs involved in amino acid and nucleotide sugar metabolism are downregulated in EIA suggesting induction of oxidative stress-alleviating genes and less priority to primary metabolism.

Conclusions
Taken together, results in this study could provide novel aspects about the molecular signaling that could be involved in coleorhiza hair development in different types of rice cultivars during seed germination and may give some hints for breeders to improve seed germination efficiency under moderate drought conditions.
Anatomical dimensions of the lumbar dural sac predict the sensory block level of continuous epidural analgesia during labor
Authors: Xu Chen-yang , Liu Can , Jin Xiao-ju , Yang Fan , Xu Fang , Qian Wan-Di , Guo Wen-jun 
Published: November 2021

Abstract
Background
The anatomical dimensions of the lumbar dural sac determine the sensory block level of spinal anesthesia; however, whether they show the same predictive value during continuous epidural anesthesia (CEA) remains undetermined. We designed the present study to verify the efficacy of the anatomical dimensions of the lumbar dural sac in predicting the sensory block level during labor analgesia.

Methods
A total of 122 parturients with singleton pregnancies requesting labor analgesia were included in this study. The lumbar dural sac diameter (DSD), lumbar dural sac length (DSL), lumbar dural sac surface area (DSA), and lumbar dural sac volume (DSV) were measured with an ultrasound color Doppler diagnostic apparatus. CEA was performed at the L2-L3 interspace. After epidural cannulation, an electronic infusion pump containing 0.08% ropivacaine and sufentanil 0.4 μg/ml was connected. The sensory block level was determined with alcohol-soaked cotton, a cotton swab, and a pinprick. The analgesic efficacy of CEA was determined with a visual analog scale (VAS). The parturients were divided into two groups, “ideal analgesia” and “nonideal analgesia,” and the groups were compared by t test. Pearson’s correlation was performed to evaluate the association between the anatomical dimensions of the lumbar dural sac and sensory block level. Multiple linear regression analysis was used to create a model for predicting the sensory block level.

Results
In the ideal analgesia group, the height, DSL, DSA, DSV and DSD were significantly smaller, and the body mass index (BMI) was significantly larger (P < 0.05). In addition, the DSL demonstrated the strongest correlation with the peak level of pain block (r = − 0.816, P < 0.0001; Fig. 2A), temperature block (r = − 0.874, P < 0.0001; Fig. 3A) and tactile block (r = − 0.727, P < 0.0001; Fig. 4A). Finally, the multiple linear regression analysis revealed that DSL and BMI contributed to predicting the peak sensory block level.

Conclusion
In conclusion, our study shows that the sensory block level of CEA is higher when the DSL, DSA, DSV and DSD of puerperae are lower. DSL and BMI can be treated as predictors of the peak sensory block level in CEA during labor analgesia.
Impact of functional capacity on change in self-rated health among older adults in a nine-year longitudinal study
Authors: Borim Flávia Silva Arbex , de Assumpção Daniela , Neri Anita Liberalesso , Batistoni Samila Sathler Tavares , Francisco Priscila Maria Stolses Bergamo , Yassuda Monica Sanches 
Published: November 2021

AbstractThe aims of the present study were to estimate the frequency of change in self-rated health (SRH) among community-dwelling older adults, between two measures taken at a 9-year interval; and determine factors associated with a decline and an improvement in SRH, in relation to aspects of physical/emotional health and subjective wellbeing. Data were derived from a community-based study on frailty among Brazilian elderly. Associations were investigated using Pearson’s chi-square test and relative risk ratios were estimated using multinomial logistic regression analysis. 39.3% of participants did not change their SRH at both assessment times, 21.7% rated it as worse and 39.0% rated it as better. The relative risk ratio of an improvement in SRH for individuals with disability in basic activities of daily living (ADLs) was lower than for individuals with independence in basic ADLs (IRR=0.22; IC95%: 0.08-0.63). Understanding the complex interactions between self-rated health and the dimensions that influence the improvement of health perception may shed light on key determinants of the wellbeing among older adults.
Late complications of biliopancreatic diversion in an older patient: a case report
Authors: Steenackers Nele , Brouwers Elien , Mertens Ann , Van Cleynenbreugel Simon , Lannoo Matthias , Flamaing Johan , Fagard Katleen 
Published: November 2021

Abstract
Background
In the mid-seventies, biliopancreatic diversion became popular as weight-loss surgery procedure. This bariatric procedure combines distal gastric resection and intestinal malabsorption, leading to greater weight loss and improvement of co-morbidities than other bariatric procedures. Nowadays, biliopancreatic diversion has become obsolete due to the high risk of nutritional complications. However, current patients with biliopancreatic diversions are aging. Consequently, geriatricians and general practitioners will encounter them more often and will be faced with the consequences of late complications.

Case presentation
A 74-year old female presented with weakness, recurrent falls, confusion, episodes of irresponsiveness, anorexia and weight loss. Her medical history included osteoporosis, herpes encephalitis 8 years prior and a biliopancreatic diversion (Scopinaro surgery) at age 52. Cerebral imaging showed herpes sequelae without major atrophy. Delirium was diagnosed with underlying nutritional deficiencies. Biochemical screening indicated vitamin A deficiency, vitamin E deficiency, zinc deficiency and severe hypoalbuminemia. While thiamin level and fasting blood glucose were normal. However, postprandial hyperinsulinemic hypoglycemia was observed with concomitant signs of confusion and blurred consciousness. After initiating parenteral nutrition with additional micronutrient supplementation, a marked improvement was observed in cognitive and physical functioning.

Conclusions
Long-term effects of biliopancreatic diversion remain relatively underreported in older patients. However, the anatomical and physiological changes of the gastrointestinal tract can contribute to the development of metabolic and nutritional complications that may culminate in cognitive impairment, functional decline and delirium. Therefore, it is warranted to evaluate the presence of metabolic disturbances and nutritional complications in older patients after biliopancreatic diversion.
Biometric covariates and outcome in COVID-19 patients: are we looking close enough?
Authors: Sharafutdinov Konstantin , Fritsch Sebastian Johannes , Marx Gernot , Bickenbach Johannes , Schuppert Andreas 
Published: November 2021

Abstract
Background
The impact of biometric covariates on risk for adverse outcomes of COVID-19 disease was assessed by numerous observational studies on unstratified cohorts, which show great heterogeneity. However, multilevel evaluations to find possible complex, e.g. non-monotonic multi-variate patterns reflecting mutual interference of parameters are missing. We used a more detailed, computational analysis to investigate the influence of biometric differences on mortality and disease evolution among severely ill COVID-19 patients.

Methods
We analyzed a group of COVID-19 patients requiring Intensive care unit (ICU) treatment. For further analysis, the study group was segmented into six subgroups according to Body mass index (BMI) and age. To link the BMI/age derived subgroups with risk factors, we performed an enrichment analysis of diagnostic parameters and comorbidities. To suppress spurious patterns, multiple segmentations were analyzed and integrated into a consensus score for each analysis step.

Results
We analyzed 81 COVID-19 patients, of whom 67 required mechanical ventilation (MV). Mean mortality was 35.8%. We found a complex, non-monotonic interaction between age, BMI and mortality. A subcohort of patients with younger age and intermediate BMI exhibited a strongly reduced mortality risk (p < 0.001), while differences in all other groups were not significant. Univariate impacts of BMI or age on mortality were missing. Comparing MV with non-MV patients, we found an enrichment of baseline CRP, PCT and D-Dimers within the MV group, but not when comparing survivors vs. non-survivors within the MV patient group.

Conclusions
The aim of this study was to get a more detailed insight into the influence of biometric covariates on the outcome of COVID-19 patients with high degree of severity. We found that survival in MV is affected by complex interactions of covariates differing to the reported covariates, which are hidden in generic, non-stratified studies on risk factors. Hence, our study suggests that a detailed, multivariate pattern analysis on larger patient cohorts reflecting the specific disease stages might reveal more specific patterns of risk factors supporting individually adapted treatment strategies.