bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully integrated sampler and dilutor in an electrochemical paper-based device for glucose sensing
Authors: Amor-Gutiérrez O. , Costa-Rama E. , Fernández-Abedul M. T. 
Published: August 2021

AbstractAn electroanalytical platform capable to take and dilute the sample has been designed in order to fully integrate the different steps of the analytical process in only one device. The concept is based on the addition of glass-fiber pads for sampling and diluting to an electrochemical cell combining a paper-based working electrode with low-cost connector headers as counter and reference electrodes. In order to demonstrate the feasibility of this all-in-one platform for biosensing applications, an enzymatic sensor for glucose determination (requiring a potential as low as −0.1 V vs. gold-plated wire by using ferrocyanide as mediator) was developed. Real food samples, such as cola beverages and orange juice, have been analyzed with the bioelectroanalytical lab-on-paper platform. As a proof-of-concept, and trying to go further in the integration of steps, sucrose was successfully detected by depositing invertase in the sampling strip. This enzyme hydrolyzes sucrose into fructose and glucose, which was determined using the enzymatic biosensor. This approach opens the pathway for the development of devices applying the lab-on-paper concept, saving costs and time, and making possible to perform decentralized analysis with high accuracy.
Graphical abstract
Moving-object detection and tracking by scanning LiDAR mounted on motorcycle based on dynamic background subtraction
Authors: Muro Shotaro , Yoshida Ibuki , Hashimoto Masafumi , Takahashi Kazuhiko 
Published: August 2021

AbstractThis paper presents a method for moving-object detection and tracking (DATMO) in global navigation satellite systems (GNSS)-denied environments using a light detection and ranging (LiDAR) mounted on a motorcycle. Distortion in the scanning LiDAR data is corrected by estimating the pose (3D positions and attitude angles) of the motorcycle in a period shorter than the LiDAR scan period using normal distributions transform-based simultaneous localization and mapping (NDT-based SLAM) and the information from an inertial measurement unit (IMU) via the extended Kalman filter (EKF). The scan data of interest are extracted by subtracting the local environment map generated by NDT-based SLAM from the LiDAR scan data. Moving objects are detected from the scan data of interest using an occupancy grid method and are tracked with a Bayesian filter. Experimental results obtained from public road and university campus environments demonstrate the effectiveness of the proposed method.
Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
Authors: Heurtaux Tony , Kirchmeyer Melanie , Koncina Eric , Felten Paul , Richart Lorraine , Uriarte Huarte Oihane , Schohn Herve , Mittelbronn Michel 
Published: August 2021

AbstractThe chiral molecule, apomorphine, is currently used for the treatment of Parkinson’s disease (PD). As a potent dopamine receptor agonist, this lipophilic compound is especially effective for treating motor fluctuations in advanced PD patients. In addition to its receptor-mediated actions, apomorphine has also antioxidant and free radical scavenger activities. Neuroinflammation, oxidative stress, and microglia reactivity have emerged as central players in PD. Thus, modulating microglia activation in PD may be a valid therapeutic strategy. We previously reported that murine microglia are strongly activated upon exposure to A53T mutant α-synuclein. The present study was designed to investigate whether apomorphine enantiomers could modulate this A53T-induced microglial activation. Taken together, the results provided evidence that apomorphine enantiomers decrease A53T-induced microgliosis, through the activation of the NRF2 signalling pathway, leading to a lower pro-inflammatory state and restoring the phagocytic activity. Suppressing NRF2 recruitment (trigonelline exposure) or silencing specifically Nfe2l2 gene (siRNA treatment) abolished or strongly decreased the anti-inflammatory activity of apomorphine. In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.
Hierarchical log Gaussian Cox process for regeneration in uneven-aged forests
Authors: Kuronen Mikko , Särkkä Aila , Vihola Matti , Myllymäki Mari 
Published: August 2021

AbstractWe propose a hierarchical log Gaussian Cox process (LGCP) for point patterns, where a set of points$$\varvec{x}$$xaffects another set of points$$\varvec{y}$$ybut not vice versa. We use the model to investigate the effect of large trees on the locations of seedlings. In the model, every point in$$\varvec{x}$$xhas a parametric influence kernel or signal, which together form an influence field. Conditionally on the parameters, the influence field acts as a spatial covariate in the intensity of the model, and the intensity itself is a non-linear function of the parameters. Points outside the observation window may affect the influence field inside the window. We propose an edge correction to account for this missing data. The parameters of the model are estimated in a Bayesian framework using Markov chain Monte Carlo where a Laplace approximation is used for the Gaussian field of the LGCP model. The proposed model is used to analyze the effect of large trees on the success of regeneration in uneven-aged forest stands in Finland.
Use of participatory mapping approaches for activity space studies: a brief overview of pros and cons
Authors: Hasanzadeh Kamyar 
Published: August 2021

AbstractParticipatory mapping approaches have raised increasing interest in a variety of fields of research and practice during the past two decades. However, their use in modeling and studying individual mobility and activity spaces is rather recent and limited. This paper focuses on the use of public participation GIS (PPGIS) data in activity space modeling and analysis and aims to draw more scholarly attention to the existing research potentials in this area. While reviewing the pros of using PPGIS for activity space studies, this paper also discusses the existing limitations and outlines how they can be addressed in future research. PPGIS effectively enables collecting data from larger samples, making it possible to conduct more comprehensive geospatial and statistical analyses on the data. Additionally, the strong link between individuals and places in PPGIS data facilitates more person-based approaches in investigating person-environment relationships. However, use of PPGIS for activity space studies comes with analytical and data quality challenges that need to be thoroughly taken into consideration. Particularly, future research needs to seek new ways of including the temporal dimension in PPGIS and find new methods of using the data for activity space modeling and analysis.
Edinburgh Lamarckians? The Authorship of Three Anonymous Papers (1826–1829)
Authors: Corsi Pietro 
Published: August 2021

AbstractIn the space of four years, from 1826 to 1829, theEdinburgh New Philosophical Journalpublished three anonymous articles seemingly advocating doctrines inspired by Jean-Baptiste Lamarck. Decades of scholarship have initially attributed the most outspoken of the three articles, the 1826 “Observations on the Nature and Importance of Geology,” to Robert Grant, and subsequently to Robert Jameson, thanks to a critical reassessment by James Secord (1991). More recently, scholars have also ascribed to Jameson an article published in 1829, “Of the Continuity of the Animal Kingdom by Means of Generation from the First Ages of the World to the Present Times.” A third short contribution, the 1827 “Of the Changes which Life has Experienced on the Globe” has been credited to the Franco-German Ami Boué. Research undertaken over several years has led to the identification of the three authors hiding behind the veil of anonymity. They were not the ones scholars have agreed upon, nor were they really “Lamarckians.” The discussion of the ways in which the three texts reached Edinburgh broadens our understanding of the daily working practices of contemporary periodicals and of the networks of circulation of texts at the Continental level. Finally, when considered within their proper conceptual and social context, the three articles throw light on the many ways in which, during the 1820s, European amateurs, naturalists, and journalists debated the succession of life forms throughout the history of the Earth.
Development of the Perth Adolescent Worry Scale (PAWS)
Authors: Hunter Simon C. , Houghton Stephen , Kyron Michael , Lawrence David , Page Andrew C. , Chen Wai , Macqueen Leslie 
Published: August 2021

AbstractTools to assess worry among adolescents exist but do not capture the content of worries. This study reports on the development of a brief, psychometrically sound measure of worry for use with adolescents. Phase 1 involved identification of 27 potential items from existing instruments as well as item generation identified in interviews with students, teachers, school psychologists, and parents. In Phase 2, the candidate items were completed by 835 Australian adolescents (317 males, 508 females, 10 unspecified; Mean age = 13.55, SD = 1.31) from Grades 5 to 10. These data were randomly split in half, and an exploratory factor analysis on the first half identified a two-factor solution with 12 items: Peer Relationships (6 items) and Academic Success and the Future (6 items). On the second half of the data, confirmatory factor analyses supported the factor structure and supported strong invariance across age, socioeconomic status, and presence/absence of a diagnosed neurodevelopmental disorder. Weak invariance was evident across sex. Differences across groups are reported as are correlations with indicators of psychological wellbeing. In conclusion, the Perth Adolescent Worry Scale provides both applied professionals and researchers with a short, easy-to-administer, and psychometrically strong instrument to evaluate adolescents’ everyday worries.
Biocompatibility studies of polyurethane electrospun membranes based on arginine as chain extender
Authors: Venegas-Cervera Georgina Alejandra , Oliva Andrés Iván , Avila-Ortega Alejandro , Cervantes-Uc José Manuel , Carrillo-Cocom Leydi Maribel , Juarez-Moreno Juan Antonio 
Published: August 2021

AbstractElectrospun polymers are an example of multi-functional biomaterials that improve the material-cellular interaction and aimed at enhancing wound healing. The main objective of this work is to fabricate electrospun polyurethane membranes using arginine as chain extender (PUUR) in order to test the fibroblasts affinity and adhesion on the material and the polymer toxicity. Polyurethane membranes were prepared in two steps: (i) the polyurethane synthesis, and ii) the electrospinning process. The membranes were characterized by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy, gel permeation chromatography, and differential scanning calorimetry techniques. The evaluation of PUUR as a scaffolding biomaterial for growing and developing of cells on the material was realized by LIVE/DEAD staining. The results show that the fluorescent surface area of human fibroblasts (hFB), was greater in control dense membranes made from Tecoflex than in electrospun and dense PUUR. From SEM analysis, the electrospun membranes show relatively uniform attachment of cells with a well-spread shape, while Tecoflex dense membranes show a non-proliferating round shape, which is attributed to the fiber’s structure in electrospun membranes. The cell morphology and the cell attachment assay results reveal the well spreading of hFB cells on the surface of electrospun PUUR membranes which indicates a good response related to cell adhesion.
Positive Illusions: The Role of Cognitive Distortions Related to Gambling and Temporal Perspective in Chasing Behavior
Authors: Nigro Giovanna , Matarazzo Olimpia , Ciccarelli Maria , Pizzini Barbara , Sacco Mariagiulia , Cosenza Marina 
Published: August 2021

AbstractChasing, or continuing to gamble to recoup previous losses, is a behavioral marker and a diagnostic criterion for gambling disorder. Even though chasing has been recognized to play a central role in gambling disorder, research on chasing is still relatively scarce. This study first empirically investigated the interplay between cognitive distortions related to gambling, temporal perspective, and chasing behavior in a sample of habitual gamblers. Two hundred and fifty-five adults took part in the study. Participants completed the South Oaks Gambling Screen (SOGS), the Gambling Related Cognitions Scale (GRCS), the 14-item Consideration of Future Consequences scale (CFC-14), and performed a computerized task assessing chasing behavior. Participants were randomly assigned to three experimental conditions (Control, Loss, and Win). Hierarchical logistic regression analysis showed that the decision to chase depended on scores on the CFC-14 Immediate scale and the GRCS dimensions Gambling Expectancies and Interpretative Bias. Hierarchical linear regression analysis indicated that, chasing frequency was affected by Loss condition, distortions related to gambling expectancies and predictive control, as well as by myopia for the future. Interestingly, the results of path analysis clearly indicated that some cognitions related to gambling predict chasing frequency not only directly, but also indirectly via shortened time horizon. Notably, gambling severity did not predict either the decision to chase, or the chasing persistence. These findings provide further evidence that nonchasers and chasers seem to belong to two quite distinct subtypes of gamblers. Such a difference could be useful for targeting more effective intervention strategies in gambling disorder treatment.
Deconstructing orchestration load: comparing teacher support through mirroring and guiding
Authors: Amarasinghe Ishari , Hernández-Leo Davinia , Ulrich Hoppe H. 
Published: August 2021

AbstractUnder the notion of “CSCL scripts”, different pedagogical models for structuring and supporting collaboration in the classroom have been proposed. We report on a practical experience with scripts based on the Pyramid collaborative learning flow pattern supported by a specific classroom tool and a teacher-facing dashboard that implements mirroring and guiding support. The input data of our analysis stems from recordings of classroom interactions guided by several teachers using the PyramidApp with different levels of teaching support. For the analysis, we introduce a specific coding scheme enabling a quantitative comparison and deeper analysis using epistemic network analysis. The results show that the guiding support enabled teachers to perform more orchestration actions, more targeted interactions and to make more announcements to the class (regarding time, phase transitions, and students’ activity participation) when compared to the mirroring support. Teachers’ actionable differences observed under the mirroring and guiding support directed us to deconstruct the notion of orchestration load into different facets and to discuss how different support provisions correspond to the different facets of orchestration load.
A Grounded Theory Study: How Non-Treatment-Seeking Substance Users Make Sense of Their Behaviour “I Want To Be Me but I Don’t Know Who Me Is”
Authors: Lawson Sarah , Griffiths Helen 
Published: August 2021

AbstractDespite the global impact of substance misuse, there are inadequate levels of specialist service provision and continued difficulties with treatment engagement. Within policy and research, there is substantial consideration of the importance of these factors. However, there is little empirical evidence of the views of non-treatment-seeking substance users, who make up the majority of the substance using population. The aim of this study was to understand how these individuals make sense of their behaviour and their reasons for not accessing treatment. A constructivist grounded theory approach was used to interview eight individuals who were currently using substances and not seeking help to stop. The analysis highlighted the importance of attachment to an identity associated with substance use, and relational variables such as connectedness to others, for treatment decisions for individuals who use substances. Understanding these influences, through trauma- and attachment-informed service provision, may reduce barriers to help-seeking and improve treatment uptake.
CT-guided percutaneous drainage of abdominopelvic collections: a pictorial essay
Authors: De Filippo Massimo , Puglisi Sara , D’Amuri Fabiano , Gentili Francesco , Paladini Ilaria , Carrafiello Gianpaolo , Maestroni Umberto , Del Rio Paolo , Ziglioli Francesco , Pagnini Francesco 
Published: August 2021

AbstractCT-guided percutaneous drainage is a safe and effective procedure that allows minimally invasive treatment of abdominopelvic abscesses and fluid collections. This technique has become an alternative for surgery with lower morbility and mortality rates. In this pictorial essay, we aim at providing an overview of the technical approaches, the main clinical indications and complications of CT-guided percutaneous drainage, in order to provide a practical guide for interventional radiologists, with a review of the recent literature. The focus will be the CT-guidance, preferred when the interposition of viscera, vascular and skeletal structures, counteracts the ultrasound guidance.
Surgical workflow recognition with 3DCNN for Sleeve Gastrectomy
Authors: Zhang Bokai , Ghanem Amer , Simes Alexander , Choi Henry , Yoo Andrew 
Published: August 2021

Abstract
Purpose
Surgical workflow recognition is a crucial and challenging problem when building a computer-assisted surgery system. Current techniques focus on utilizing a convolutional neural network and a recurrent neural network (CNN–RNN) to solve the surgical workflow recognition problem. In this paper, we attempt to use a deep 3DCNN to solve this problem.

Methods
In order to tackle the surgical workflow recognition problem and the imbalanced data problem, we implement a 3DCNN workflow referred to as I3D-FL-PKF. We utilize focal loss (FL) to train a 3DCNN architecture known as Inflated 3D ConvNet (I3D) for surgical workflow recognition. We use prior knowledge filtering (PKF) to filter the recognition results.

Results
We evaluate our proposed workflow on a large sleeve gastrectomy surgical video dataset. We show that focal loss can help to address the imbalanced data problem. We show that our PKF can be used to generate smoothed prediction results and improve the overall accuracy. We show that the proposed workflow achieves 84.16% frame-level accuracy and reaches a weighted Jaccard score of 0.7327 which outperforms traditional CNN–RNN design.

Conclusion
The proposed workflow can obtain consistent and smooth predictions not only within the surgical phases but also for phase transitions. By utilizing focal loss and prior knowledge filtering, our implementation of deep 3DCNN has great potential to solve surgical workflow recognition problems for clinical practice.
Associations between biomarkers of multimorbidity burden and mortality risk among patients with acute dyspnea
Authors: Wessman Torgny , Tofik Rafid , Ruge Thoralph , Melander Olle 
Published: August 2021

AbstractThe patients’ burden of comorbidities is a cornerstone in risk assessment, clinical management and follow-up. The aim of this study was to evaluate if biomarkers associated with comorbidity burden can predict outcome in acute dyspnea patients. We included 774 patients with dyspnea admitted to an emergency department and measured 80 cardiovascular protein biomarkers in serum collected at admission. The number of comorbidities for each patient were added, and a multimorbidity score was created. Eleven of the 80 biomarkers were independently associated with the multimorbidity score and their standardized and weighted values were summed into a biomarker score of multimorbidities. The biomarker score and the multimorbidity score, expressed per standard deviation increment, respectively, were related to all-cause mortality using Cox Proportional Hazards Model. During long-term follow-up (2.4 ± 1.5 years) 45% of the patients died and during short-term follow-up (90 days) 12% died. Through long-term follow-up, in fully adjusted models, the HR (95% CI) for mortality concerning the biomarker score was 1.59 (95% CI 1348–1871) and 1.18 (95% CI 1035–1346) for the multimorbidity score. For short-term follow-up, in the fully adjusted model, the biomarker score was strongly related to 90-day mortality (HR 1.98, 95% CI 1428–2743), whereas the multimorbidity score was not significant. Our main findings suggest that the biomarker score is superior to the multimorbidity score in predicting long and short-term mortality. Measurement of the biomarker score may serve as a biological fingerprint of the multimorbidity score at the emergency department and, therefore, be helpful for risk prediction, treatment decisions and need of follow-up both in hospital and after discharge from the emergency department.
Estimation of Bone Trace Elements Following Prolonged Every-other Day Feeding in C57BL/6 Male and Female Mice
Authors: Zgutka Katarzyna , Piotrowska Katarzyna , Bosiacki Mateusz , Pawlik Andrzej , Tarnowski Maciej 
Published: August 2021

AbstractThe purpose of this study was to examine the effect of prolonged every-other day (EOD) feeding on bone trace elements. Four-week old C57BL/6 female (n = 12) and male (n = 12) mice were employed in this experiment. Animals were assigned to four groups: ad libitum—AL (males and females), EOD fed (males, females). After 9 months, the mice were sacrificed. Long bones (humerus and radius) were isolated and prepared for analysis using inductively coupled plasma optical emission spectrometry to determine the Fe, Zn, Mo, Co, Cu, Mn, Cr contents. Estimation of cathepsin K expression on bone slides was performed to determine the activity of osteoclasts in bones of EOD- and AL-fed animals. Higher content of Fe in EOD-fed females compared to AL-fed females was found. In EOD-fed males, a significantly higher amount of Mo (p < 0.005) and Co (p < 0.05) in comparison to AL-fed males was noted. Gender differences in amounts of trace elements in control AL-fed males vs. females were observed. EOD feeding influences the amount of some trace elements in long bones of female and male C57BL/6 mice. However, this is not influenced by the activity of bone cells.
Occurrence of Volcanogenic Inorganic Mercury in Wild Mice Spinal Cord: Potential Health Implications
Authors: Navarro-Sempere A. , García M. , Rodrigues A. S. , Garcia P. V. , Camarinho R. , Segovia Y. 
Published: August 2021

AbstractMercury accumulation has been proposed as a toxic factor that causes neurodegenerative diseases. However, the hazardous health effects of gaseous elemental mercury exposure on the spinal cord in volcanic areas have not been reported previously in the literature. To evaluate the presence of volcanogenic inorganic mercury in the spinal cord, a study was carried out in São Miguel island (Azores, Portugal) by comparing the spinal cord of mice exposed chronically to an active volcanic environment (Furnas village) with individuals not exposed (Rabo de Peixe village), through the autometallographic silver enhancement histochemical method. Moreover, a morphometric and quantification analysis of the axons was carried out. Results exhibited mercury deposits at the lumbar level of the spinal cord in the specimens captured at the site with volcanic activity (Furnas village). A decrease in axon calibre and axonal atrophy was also observed in these specimens. Given that these are relevant hallmarks in the neurodegenerative pathologies, our results highlight the importance of the surveillance of the health of populations chronically exposed to active volcanic environments.