bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Combined Encorafenib and Binimetinib Treatment for Erdheim–Chester Disease Harboring Concurrent BRAFV600E and KRASG12R Mutations: A Case Report
Authors: Hibino Yuto , Sakai Rika , Takahashi Hiroyuki , Takeda Takaaki , Hirose Natsuki , Tokunaga Mayumi , Washimi Kota , Yokose Tomoyuki , Kasajima Rika , Hiroshima Yukihiko , Miyagi Yohei , Nakajima Hideaki 
Published: December 2024

ABSTRACTBackgroundErdheim–Chester disease (ECD) is a rare form of non‐Langerhans cell histiocytosis with diverse clinical manifestations, often associated with mutations in the mitogen‐activated protein kinase/extracellular signal‐regulated kinase (MAPK/ERK) pathway. BRAF and KRAS mutations, which are driver mutations of oncogenes, participate in the same signaling pathway (MAPK/ERK pathway) and are usually mutually exclusive. We report a case of ECD with concurrent BRAFV600E and KRASG12R mutations treated using BRAF and MEK inhibitors.CaseA 70‐year‐old man was referred to our hospital with a mesenteric nodal lesion on computed tomography scan. The patient experienced symptoms consistent with ECD, including central diabetes insipidus. Biopsy revealed histiocytes positive for CD68 and CD163, negative for S100, CD1a, and CD21. Liquid‐based comprehensive genomic profiling and tissue‐based cancer gene panel test identified BRAFV600E and KRASG12R mutations with different variant allele fraction. Additional immunohistochemistry with an antibody specific to mutant BRAFV600E protein stained some proliferating histiocytes, consistent with ECD. Based on the genomic profiling results, we hypothesized that there was a coexistence of a clone harboring BRAFV600E and another clone harboring KRASG12R, and planned a combination therapy with BRAF and MEK inhibitors targeting each clone, respectively. The patient received oral encorafenib at 100 mg once daily and oral binimetinib at 15 mg twice daily. The combination therapy resulted in rapid resolution of symptoms and significant improvement in imaging findings.ConclusionThis case represents a unique presentation of ECD with concurrent BRAFV600E and KRASG12R mutations. Combination therapy with encorafenib and binimetinib targeting each clone resulted in a remarkable therapeutic effect and was well‐tolerated. This is the first reported case of ECD treated with encorafenib and binimetinib. The combination therapy with BRAF and MEK inhibitors is one of the rational treatment options for cases of ECD with a suspicion of multiple clones.
Deep Eutectic Solvents as Electrolytes for Zn Batteries: Between Blocked Crystallization, Electrochemical Performance and Corrosion Issues
Authors: Gregorio Victor , Baur Christian , Jankowski Piotr , Chang Jin Hyun 
Published: December 2024

AbstractDeep eutectic solvents (DESs) are an emerging class of ionic liquids with high tunability and promise for battery applications. In this study, we investigated acetamide‐based DESs for Zn batteries, focusing on a synergistic mixture of two known acetamide (Ace)‐based DESs:
and
. By combining these two DESs in various ratios, we aimed to enhance ionic conductivity and optimize electrochemical performance while addressing corrosion concerns. The resulting ternary mixtures exhibit superior ionic mobility, with the highest conductivity observed for
, which balances performance and stability. However, increased ionic mobility introduces crystallization challenges, limiting liquid‐phase stability. Despite these challenges, the optimized DES mixture demonstrates excellent cycling performance with reduced overpotentials and acceptable corrosion levels, offering a viable pathway for scalable Zn battery applications.
Early Warning Signs for Eating Disorders in Children: A Realist Synthesis of Websites Summarizing Caregiver and Consumer Perspectives
Authors: Pennesi Jamie‐Lee , Jabs Maya , Baillie Simone , Hart Laura , Hay Phillipa , Mitchison Deborah , Norton Lyza , Prnjak Katarina , Wade Tracey D. 
Published: December 2024

ABSTRACTObjectiveA larger number of younger children are being diagnosed with an eating disorder (ED), with parents typically reporting a delay between early warning signs (EWS) and seeking help. The aim of the current investigation was to identify the common EWS for EDs in children noticed by caregivers and consumers as reported on websites to inform earlier detection and intervention.MethodA realist synthesis of websites summarizing caregiver and consumer perspectives on the EWS for EDs in children was conducted by searching Google, Bing, and Yahoo! for all years covered through 24 October 2023.ResultsThe initial search identified 140 websites, of which 62 met criteria for eligibility (93.5% summarized content targeted at caregivers, 6.5% included direct perspectives). Six categories and 24 sub‐categories of EWS were identified across 214 individual EWS. The most common EWS, mentioned in at least 40% of websites, were: excessive or compulsive exercise, any weight loss, obsession or preoccupation with food or food preparation, and cutting out major food groups.DiscussionThis web synthesis identified the EWS of developing EDs in children most reported by caregivers and consumers; however, many of the websites contained subjective interpretations of people's experiences which were unverified and may capture potential bias. Future prospective research is required to verify caregiver and consumer experiences and to explore whether these EWS are predictive of ED onset. These results can then inform early detection strategies for EDs and may assist caregivers in recognizing when clinical assessment for an ED is required.
Function over form: The benefits of aspen as surrogate brood‐rearing habitat for greater sage‐grouse
Authors: Kohl Michel T. , Sandford Charles P. , Rogers Paul C. , Chi Renee , Messmer Terry A. , Dahlgren David K. 
Published: December 2024

AbstractSpecies of conservation concern are often habitat specialists, posing significant risk to those species when specific plant communities are threatened. As a result, practitioners habitually focus conservation efforts on these communities while ignoring ecological mechanisms that explain the wildlife–plant relationships. In doing so, practitioners may overlook alternative vegetation communities that could maintain wildlife populations under alternative conditions (e.g., climate change). Here, we term these areas surrogate habitat, defined as vegetation communities or resource sites that provide similar critical resources as conventional sites, and assess their potential for conservation using a case study of greater sage‐grouse (Centrocercus urophasianus) on Parker Mountain, Utah (1998–2009). Sage‐grouse are a sagebrush‐obligate species and a species of conservation concern. Range‐wide conservation efforts have long emphasized management of seasonal habitats within semiarid sagebrush ecosystems, specifically management of mesic or wet meadow sites that provide brood‐rearing habitat required for population persistence. Despite this requirement, no conventional mesic habitat exists on Parker Mountain, yet it supports one of Utah's largest sage‐grouse populations. Rather, the Parker sagebrush system abuts quaking aspen (Populus tremuloides) stands that may provide brood‐rearing habitat analogous to wet meadow sites. It is unclear, however, to what extent sage‐grouse use these aspen stands because sage‐grouse commonly avoid tall structures (e.g., trees) and their associated avian predators. Thus, we tested whether (1) sage‐grouse selected for surrogate habitat (i.e., aspen edge) and (2) selection behaviors related to surrogate habitat had demographic effects on the population. As we predicted, sage‐grouse selected for these areas, and the sage‐grouse that spent increased time closer to aspen edges did not experience increased mortality. Together, this demonstrates that the aspen–sagebrush edge provided a surrogate for the wet meadows used by other populations. More broadly, this suggests that conservation practitioners should move beyond simplistic wildlife–habitat associations toward a more holistic view of animal ecology focused on the wildlife–resource association, an approach that becomes particularly useful in areas where conventional obligate habitat may be degraded or lost. This work also implores us to examine alternative habitat potential rather than applying one‐size‐fits‐all models to threatened species conservation.
Natural and anthropogenic noise shape bat activity and sonar behavior
Authors: Vosbigian Ryan , Wardle Ryan , Rempel Hannah S. , Brauer Ellie , Huggins Michael , West Samantha , Willems Joshua S. , Francis Clinton D. 
Published: December 2024

AbstractAs human development has expanded, so has the prevalence of anthropogenic noise, which can interfere with acoustic channels used by wildlife. However, since landscapes contain natural sources of persistent noise from features such as rivers, animals may be preadapted to cope with novel human‐generated noise. Comparing how animals respond to anthropogenic and natural noise with similar properties can provide insight into how and why animals may respond to increasing noise pollution. Here, we studied whether Mexican free‐tailed bats (Tadarida brasiliensis) alter activity and call features in response to playback of traffic and river noise relative to ambient acoustics. We observed higher call activity during ambient and traffic playback compared with river playback conditions. These findings suggest that T. brasiliensis may select areas based on acoustic properties and not by associating river sounds with more favorable habitat. We also observed that T. brasiliensis modified call duration and frequency in response to river playbacks in a manner consistent with a behavioral switch from foraging to navigating. Overall, we found evidence that temporal patterning of noise may strongly influence bat activity and that signaling in noise may involve trade‐offs among call features.
A Review on Recent Developments in Transition Metal and Heteroatom‐Doped Carbon Catalysts for Oxygen Reduction Reaction
Authors: Jannath Khatun A. , Saputra Heru Agung 
Published: December 2024

ABSTRACTOxygen reduction reaction (ORR) is key in many green energy conversion devices like fuel cells and metal‐air batteries. Developing cheap and robust electrocatalysts is crucial to expedite the slow ORR kinetics at the cathode. Lately, transition metal (TM) and heteroatom‐doped carbon catalysts have surfaced as promising cathode materials for ORR as they display admirable electrocatalytic activity and distinguished properties like tunable morphology, structure, composition and porosity. This review summarizes the recent breakthrough in TM (Fe, Co, Mn and Ni) and heteroatoms (N, S, B, P and F) doping in carbon materials. Moreover, their ORR activity and active sites are inspected for future augmentation in making ORR catalysts for electrochemical devices. The existing challenges and prospects in this field are ratiocinated in conclusion.
Epileptiform discharges in the context of self‐limited pediatric focal epilepsy (EDSelFEC) in pediatric hemispherotomy patients: Role of white matter abnormalities
Authors: Tarta‐Arsene Oana , Winkler Peter , Pieper Tom , Hartlieb Till , Zsoter Andrea , Stan Irina , Kudernatsch Manfred , Berweck Steffen , Holthausen Hans 
Published: December 2024

AbstractObjectiveTo investigate the frequency of epileptiform discharges associated with self‐limited focal epilepsy (EDSelFEC) in children who have undergone a hemispherotomy and to evaluate whether patients with coexistence of EDSelFEC and structural hemispheric epilepsies differ from patients without coexistence of EDSelFEC and whether there are differences between the two groups with regard to preoperative management and postoperative outcome.MethodsData on 131 children who underwent a hemispherotomy between January 1999 and January 2015 were retrieved from the Epilepsy center's epilepsy surgery database. Children with EDSelFEC were compared with children without EDSelFEC with respect to epileptogenic hemispheric pathology, family history, age at epilepsy onset, timing of surgery, lesion laterality, preoperative cognitive function, response to sodium channel blocker antiepileptic medication, and surgical outcome. Parental consent was obtained.ResultsEDSelFECs were present in the EEG in 27 (21%) of the 131 cases. None of the patients had seizures associated with EDSelFECs. The percentages of EDSelFECs varied between pathology groups: vascular lesions: 38%, focal cortical dysplasia: 16%, polymicrogyria: 5%, Rasmussen encephalitis: 10%, hemimegalencephaly: 8%, mild malformation of cortical development with oligodendroglial hyperplasia:20%, other pathologies: 22%. EDSelFEC in the vascular group were significantly correlated with MRI changes showing white matter damage in addition to cortical damage (p =.02). 82.1% of EDSelFEC were located multifocal versus 4.8% multifocality in EDs other than EDSelFEC. EDSelFEC were significantly more often exacerbated by sodium channel blockers than EDs caused by structural (cortical) lesions. No differences were found between EDSelFEC+ and EDSelFEC− patients with respect to other variables studied.SignificanceA significant number of children with hemispheric epileptogenic lesions, particularly children with pre‐/perinatal vascular lesions, hemiplegia, and white matter lesions in addition to cortical lesions, presented with coexisting EDSelFEC.
Experimental Investigations of Sediment Erosion in Francis Turbine Using Non‐Recirculating Sediment Test Rig
Authors: Poudel Ravi , Chitrakar Sailesh , Qian Zhongdong , Thapa Bhola 
Published: December 2024

ABSTRACTWater‐suspended sediments wear down hydro turbine components by erosion, reducing their lifetime. Nonetheless, even heavily sediment‐loaded rivers are a valuable renewable and clean energy resource. Forecasting sediment erosion and optimizing the hydraulic turbine design for extended durability by numerical flow simulations became imperative to operate the hydropower plant safely and economically in sediment‐laden environments. This strategy is challenged by the unknown model parameters, that is, the lack of reliable validation data. Therefore, in this study, a 2 kW Francis‐type model turbine is tested in a non‐recirculating sediment‐laden test facility. The Francis turbine runner and the guide vanes are coated with four different colors to visualize locations of surface degradation qualitatively due to erosion during operation in representative sediment concentrations. The turbine is tested at two different operating conditions OP1 and OP2 for visualizing the locations of erosion. For operating condition OP1, with low rotational speed, erosion is primarily observed at the leading and trailing edge of the suction and pressure side, respectively. The Francis turbine runner is particularly eroded in the transition between the hub and the blades on the suction side towards the trailing edge. Meanwhile, for operating condition OP2, with higher rotational speed, the trailing edge of the pressure side of the blade and the region of the shroud close to the trailing edge of the blades are found to be vulnerable to erosion. Test for the material erosion of the runner is conducted at OP3 conditions with high sediment concentration over 45 h, reporting the weight loss in intervals of 15 h. It is observed that the cumulative erosion rate of the Francis runner made of brass material is 0.016 mg g−1 h−1 after 45 h of operation. Similarly, the percentage loss of the runner with respect to the hours of operation is calculated to be 0.0065%, 0.04%, and 0.07% for 15, 30, and 45 h of operation, respectively. This data set can also be useful for qualitative and quantitative validation of computational fluid dynamic simulations for erosion prediction.
A Climate Simulation Dataset From 11 Overriding Experiments for Analysing Cloud and Air–Sea Feedbacks
Authors: Guo Xiao , Feng Biao , Zhao Zhiying , Ma Jian 
Published: December 2024

ABSTRACTUnder global warming, cloud change and its radiative feedback have often been considered to evolve from thermodynamic processes; however, cloud feedback may also force sea surface temperature to trigger such air–sea interactions. Due to complex cloud physics in air–sea coupling, this contributes to the surface warming pattern formation with significant uncertainty. Here we develop a novel overriding technique for climate projections that substitutes specific variables in control runs to isolate such feedback mechanisms, decoupling thermodynamic, dynamical and radiative responses of the surface ocean to the atmosphere. We apply this to the Community Earth System Model version 2 (CESM2) and perform a series of 150‐year simulations with 1% CO2 increase per year (1pctCO2). In real time, the key variables under 1pctCO2 are replaced with those from the current climate, such as downwelling shortwave radiation, wind speed in latent and sensible heat and wind stress. These experiments provide monthly output of global distributions including surface temperatures, winds and precipitation, with a spatial resolution of 1.9° × 2.5° in latitude and longitude and 32 levels for the atmosphere and of ~1° and 60 layers designated as gx1v7 for the ocean. This open access dataset for partial air–sea coupling under climate change can help understand the tropical and polar warming patterns and quantify the relative contributions of forcing and triggering mechanisms.
Assessment of Hydrologic Data Estimates From ERA5 Reanalyses in Benin, West Africa
Authors: Bodjrènou René , Sintondji Luc Ollivier , N'Tcha Yekambessoun M' Po , Germain Diane , Azonwade Francis Esse , Sohindji Fernand , Hounnou Gilbert , Amouzouvi Edid , Kpognin Arthur Freud Segnon , Comandan Françoise 
Published: December 2024

ABSTRACTIn West Africa, the validation of distributed models is limited by the quality and availability of point station data measured in situ. ERA5 is a climate reanalysis product produced by the European Centre for Medium‐range Weather Forecasts (ECMWF) and is suggested to overcome this constraint. This study assessed and compared the quality of ERA5 and its variant ERA5‐Land (namely, LAND) over Benin at spatial and monthly time scales. ERA5 relies on a single‐level version with a 0.25° × 0.25° resolution, while LAND is a land surface version with a 0.1° × 0.1° resolution. Four variables were collected, namely, surface runoff (SRO), evapotranspiration (PET), water table depth (WTD) and soil water content (SWC). Single nearest pixel (SNP) and inverse distance weighting (IDW) selection methods were used to compare the reanalyse data to point station data based on the correlation (c), mean absolute error (MAE) and relative mean absolute error (RMAE). With the SNP method, both reanalyses showed a best peak simulation in mean SRO. Their performance in terms of correlation ranged from 0.26 to 0.65 for ERA5 vs. 0.34 to 0.60 for LAND. The reanalyses showed high correlations (generally > 0.80) for SWC and for the PET (sometime greater than 0.90). The correlations were below 0.5 in both reanalyses for the WTD, with slight overestimations (4.73 m for ERA5 vs. 3.13 m for LAND). Similar results were reported with the IDW selection method. One or the other of the two reanalyses can be recommended for model calibration/validation, but care must be taken in the choice because the one chosen may be better in terms of correlation even though it has significant biases and vice versa. Correcting the variables of these reanalysis datasets could also improve their performance.
Advancing Thalamic Nuclei Segmentation: The Impact of Compressed Sensing on MRI Processing
Authors: Hübner Sebastian , Tambalo Stefano , Novello Lisa , Hilbert Tom , Kober Tobias , Jovicich Jorge 
Published: December 2024

ABSTRACTThe thalamus is a collection of gray matter nuclei that play a crucial role in sensorimotor processing and modulation of cortical activity. Characterizing thalamic nuclei non‐invasively with structural MRI is particularly relevant for patient populations with Parkinson's disease, epilepsy, dementia, and schizophrenia. However, severe head motion in these populations poses a significant challenge for in vivo mapping of thalamic nuclei. Recent advancements have leveraged the compressed sensing (CS) framework to accelerate structural MRI acquisition times in MPRAGE sequence variants, while fast segmentation tools like FastSurfer have reduced processing times in neuroimaging research. In this study, we evaluated thalamic nuclei segmentations derived from six different MPRAGE variants with varying degrees of CS acceleration (from about 9 to about 1‐min acquisitions). Thalamic segmentations were initialized from either FastSurfer or FreeSurfer, and the robustness of the thalamic nuclei segmentation tool to different initialization inputs was evaluated. Our findings show minimal sequence effects with no systematic bias, and low volume variability across sequences for the whole thalamus and major thalamic nuclei. Notably, CS‐accelerated sequences produced less variable volumes compared to non‐CS sequences. Additionally, segmentations of thalamic nuclei initialized from FastSurfer and FreeSurfer were highly comparable. We provide the first evidence supporting that a good segmentation quality of thalamic nuclei with CS T1‐weighted image acceleration in a clinical 3T MRI system is possible. Our findings encourage future applications of fast T1‐weighted MRI to study deep gray matter. CS‐accelerated sequences and rapid segmentation methods are promising tools for future studies aiming to characterize thalamic nuclei in vivo at 3T in both healthy individuals and clinical populations.
Silencing Quiet Quitting: Crafting a Symphony of High‐Performance Work Systems and Psychological Conditions
Authors: Agarwal Promila , Kaur Prabhjot , Budhwar Pawan 
Published: December 2024

ABSTRACTA key question in the literature is how human resource management (HRM) practices influence quiet quitting (QQ), emphasizing the need for a more nuanced theoretical framework to explain its antecedents. This research applies the conservation of resources (COR) theory to delve into how high‐performance work systems (HPWSs) influence QQ through psychological conditions (i.e., psychological meaningfulness and availability). Based on a sample of 422 participants, the study reveals that HPWSs, psychological meaningfulness, and psychological availability each have a negative relationship with QQ. In addition, psychological meaningfulness and availability serve as mediating pathways through which HPWSs can mitigate QQ. The findings pave the way for further research on effective interventions and management practices that can create more fulfilling and productive work environments.