bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH CARA PENGERINGAN SIMPLISIA TERHADAP KADAR FENOLIK DAN AKTIVITAS TABIR SURYA EKSTRAK ETANOL 70% DAUN CINCAU HIJAU (Cyclea barbata Miers.)
Authors: Rusmawati Lisa , Rahmawan Sjahid Landyyun , Fatmawati Sofia 
Published: June 2021

Extract cincau leaves green according to previous studies have the value of the antioxidant IC50 49,45±0,64 µg/mL. According to researchers the phenol formerly produced through a method of drying oven with higher than the drying with sunlight and dried use wind. The research aims to understand the influence of means drying simplisia against phenolic levels total and the activity of a natural sunscreen on extract ethanol 70 % cincau leaves green (Cyclea barbata Miers). Drying simplisia in research is divided into three which is drying with the dry wind, the sun, and an oven. Green leaves cincau simplisia extracted by using the method maceration. Testing the phenolic committed using the folin ciocalteu method. The determination is based on the SPF value Mansur. The results of the value of phenolic or on the program have managed to extract by the difference means drying simplisia dry wind, the rays of the sun and an oven respectively namely 32,7089; 46,2500 and 59,5500 mgGAE / g. The SPF value obtained from each extract with different methods of drying simplisia showed significant differences in various concentration test.
Liderazgo Educativo en tiempos post pandemia
Authors: Serrano Gabriela 
Published: June 2021

La historia de la humanidad ha estado marcada por crisis que han redefinido a la sociedad. Las crisis suelen tener una doble connotación, por un lado, dejan una huella dolorosa, pero por otro pueden ser catalizadoras de una insorteable renovación. Ser líder educativo en tiempos de incertidumbre es todo un desafío, y si algo ha traído la pandemia COVID -19 es precisamente carestía de certezas. No obstante, se pueden encontrar luces oportunas que orienten la praxis docente y dicho liderazgo. Este tiempo ha dejado en evidencia la importancia de ser flexibles, de salir de modelos homogéneos y de animarse a hacer reinvenciones. En este sentido, este articulo busca ser un espacio de reflexión desde una mirada filosófica que deje un espíritu tanto crítico como esperanzador. Por tal, se propone el objetivo general: Compartir los aportes claves desde una mirada filosófica educativa para el Liderazgo Educativo en tiempos post pandemia Y los objetivos específicos: 1. Reflexionar sobre la importancia de la priorización de lo que se debe enseñar. 2. Analizar los métodos de enseñanza en tiempos post pandemia 3. Proponer espacios idóneos para el aprendizaje.
Experiencia de gestión en época de pandemia
Authors: Fuenmayor Luz 
Published: June 2021

Gestionar al interior de una organización tan compleja como Fe y Alegría es un gran reto, aún más cuando esta gestión se desarrolla en tiempos de emergencia humanitaria y de crisis educativa. Mantener como elemento prioritario el cumplimiento de la misión y cohesionar los cuatro programas que hacen vida en el movimiento requiere de una organización diferente, para que la respuesta a la realidad sea diferente y adecuada al contexto. El equipo de monitoreo, asume el liderazgo de esa gestión con una organización propia y define su proceso de acompañamiento y seguimiento a las acciones que se desarrollan en el marco de la pandemia. La reflexión permanente del contexto, la búsqueda de alternativas y respuestas, la formación, la planificación y la evaluación son también elementos permanentes en una gestión que tiene como principio:”Hacer el bien y hacerlo bien”. Para ello favorece la participación, el diálogo y el consenso entre todos los actores. Es una experiencia mucho más rica de lo que puede recogerse en las minutas de las reuniones y en los documentos producidos.
Problems and Prospects of SME Financing in Bangladesh
Authors: Alam Khan Md. Shahin , Hasan Aminul , Paul Jitesh , Chowdhury Salmana 
Published: June 2021

To conduct a comprehensive study on the SME sector of Bangladesh of its present state, prospects, issues and emerging challenges this “problems & Prospects of SME Financing in Bangladesh” research is carried out. The main objective of the study is to find out the SME financing’s different types of strategies & policies in Bangladesh. The SMEs are playing gradually more significant role as a mainstream of economic escalation in Bangladesh as well as all over the world. The SME usually creates the opportunities of employment at lower costs and render flexibility to the economy. The SMEs are playing an indispensable role for overall economic development. Since this sector is a manual labor intensivewith the short period of time, usually it is capable of increasing the national income as well as hasty employmentcreation by achieving the Millennium Development Goals (MDGs) as well as the abolition of extremepoverty and starvation, gender equality and women empowerment. This SME sector has played a vital role intheeconomic progress of some prosperous countries of Asia. In national economy of Bangladesh SMEs play mainly vital role by making manufacturing enterprises by providing the employment of industrial workers and contributing to the over one-third of industrial value-added to gross domestic product (GDP) and become accustomed quickly to change the market condition, create employment, help diversify economic activities, and also make a significantcontribution to the exports and trade. The economic competence and the overall performance of the SMEs are considerably depended upon the policy of environmental and specific promotional policies pursued for their benefits. Consequently, the policies and initiatives to develop the condition of SMEs and toincrease their competitiveness are a main concern of Bangladesh.
The Severity of Malaria and Toxoplasmosis Co-Infections among Pregnant Women in Yaounde, Cameroon
Authors: Ndamukong-Nyanga Judith Lum , Linda Kitio Falone , Lucile Signi Todjom Chysine , Dolly-Misper Demanou Teubow 
Published: June 2021

Malaria and toxoplasmosis are two diseases caused by parasites of the same phylum (Apicomplexa). They have severe consequences on the health of pregnant women and their unborn babies. As such, they are of importance for the public health, especially in Sub-Saharan Africa and Cameroon. The aim of this study was to evaluate the severity of toxoplasmosis among malaria-positive pregnant women attending the Biyam-Assi District Hospital. It was a cross-sectional study that took place from May to November 2019 involving 232 pregnant women who voluntarily accepted to take part in the study. Demographic data was collected using structured questionnaires and blood was collectd by finger prick. Thick blood films were prepared for the detection of malaria and the Giemsa-stained slides were read microscopically. A drop of blood was used for the detection of toxoplasmosis using the chromatographic cassette (Rapid Diagnostic Test) and the results were read after 15 minutes. The data obtained was analysed using SPSS version 24. The results showed that the prevalence of toxoplasmosis was 22.84 %. This prevalence didn’t depend on the trimester of pregnancy (P = 0. 08). The prevalence of malaria was 38.9%. No significant difference was observed for either the prevalence or severity of malaria over the three trimesters of pregnancy (p = 0.60 and p = 0.9 respectively). The prevalence of co-infection with malaria and toxoplasmosis was 9.05%. Women without toxoplasmosis were more prone to severe malaria (20.29 %) than their counterparts who had toxoplasmosis (4.78 %) and the difference between these two groups was statistically significant (p = 0.02). The severity of toxoplasmosis was not influenced by the presence of Plasmodium (p = 0. 20). It was concluded that the occurrence and severity of toxoplasmosis in pregnant women does not depend on their malaria serological status. However, the presence of severe malaria in pregnant women depends on their toxoplasmosis status. Indeed, women already infected with T. gondii are less susceptible to malaria than their counterparts who are negative for toxoplasmosis. These findings suggest that T. gondii in a person confers some form of reistance to infections with Plasmodium. It was recommended that the Public Health Ministry in Cameroon could include screening for toxoplasmosis among the routine test for pregnant women in order to improve on the health of mother and baby.
Flexible and Biocompatible Physical Unclonable Function Anti‐Counterfeiting Label
Authors: Hu Yan‐Wei , Zhang Tai‐Ping , Wang Chun‐Feng , Liu Kai‐Kai , Sun Yuan , Li Lei , Lv Chao‐Fan , Liang Ya‐Chuan , Jiao Fu‐Hang , Zhao Wen‐Bo , Dong Lin , Shan Chong‐Xin 
Published: June 2021

AbstractOptical physical unclonable functions (PUFs) have been proven to be one of the most effective anti‐counterfeiting strategies. However, optical PUFs endowed with flexibility and biocompatibility have not been developed, limiting their application scenarios. Herein, biocompatible and flexible optical PUF labels are developed by randomly embedding microdiamonds in silk fibroin films. The PUF labels can be conformally attached onto the surface of complex shaped objects, providing the desired protection against fake and interior products. In this system, silk fibroin films serve as a flexible and biocompatible substrate, while the Raman signal of the microdiamonds serves as response of the excitation. The extremely high stability and random distribution of the microdiamonds ensure the performance of PUFs, and the maximum encoding capability of 210000 is finally realized. The cytotoxicity analysis results also verify the biosafety of the PUF system. In addition, the as‐prepared PUF labels are attached onto the surface of polyethylene material, and human skin, and even have been implanted under chicken skin tissue, promising their practical applications.
Pressurized Alloying Assisted Synthesis of High Quality Antimonene for Capacitive Deionization
Authors: Gao Yujie , Lin Cheng , Zhang Kan , Zhou Wenhan , Guo Shiying , Liu Wenqiang , Jiang Lianfu , Zhang Shengli , Zeng Haibo 
Published: June 2021

AbstractMono‐elemental antimonene as a new member of the 2D material family has recently attracted huge attention, whereas the higher chemical activity and narrower interlayer gallery have impinged the quality of product upon exfoliation from the bulk counterpart. To overcome the intrinsic drawbacks, along with the line of the liquid‐phase exfoliation (LPE) method, here, a pressurized alloying approach introduces a Li3Sb alloy intermediate at the edge region of bulk β‐phase antimony by pre‐lithiation in the presence of n‐butyllithium and internal pressure is put forward. A protonation process converts the Li3Sb to gaseous stibine (SbH3) in a liquid solution, enabling an upward buoyancy together with the endothermic opening of the galleries that facilitate the subsequent LPE. As a result, the β‐phase antimony is efficiently exfoliated into antimonene nanosheets with perfect retention of basal plane texture (lateral size of ≈3 µm and thickness of less than 2 nm). Finally, the high‐quality antimonene being simply treated with HCl enables great Na+ diffusion along the basal plane to deliver excellent capacitive deionization performance with a salt adsorption capacity of 31.4 mg g–1 at an ultra‐low NaCl concentration (135 mg L–1).
Electrostatics of Single Monolayer Graphene Coated Metal Electrode in Electrolyte
Authors: Saraf Akshat R. , Keramatnejad Kamran , Arcila Jennifer A. , Saraf Ravi F. 
Published: June 2021

AbstractUnlike metals, graphene forms a hydration layer at the electrode/electrolyte interface, which is unusual for a conducting material. Here, the electrostatic properties of the hydration layer are studied by measuring the oscillation of ions at the interface due to an applied AC potential by differential reflectivity during cyclic voltammetry (CV). The amplitude of ion oscillation at picometer range sensitivity on a partially coated Au electrode by a graphene monolayer reveals a remarkable difference between the coated and uncoated part of the electrode. The uncoated Au electrode exhibits the expected behavior, but the oscillation of ions is completely screened over the graphene coated electrode up to 0.2 M of NaCl. The “insulating” behavior is consistent with CV and DPV. The behavior attributed to the hydration layer could be reversibly disrupted to de‐screen the electric field to study the electrostatics of graphene/Au interface. The shift in Fermi level of hydration‐layer‐free graphene/Au relative to Au is quantitatively consistent with work function transparency of graphene. The cut‐off of the emanating field from the underlying electrode in an electrolyte is another example of graphene's unique passivation property that will have profound effect on applications such as, supercapacitors where the charge state of interface is critical.
Stable Cobalt Porphyirn Ometed Type Small Molecule Sensor for the Sensitive and Selective Detection of Ammonia Gas at Room Temperature
Authors: Shah Muhammad Naeem , Pathipati Srinivasa Rao , Mehmood Shahid , Kahn Faheem Ullah , Sohail Muhammad , Ullah Bakhtar , Yang Yatao , Pan Xiaofang 
Published: June 2021

AbstractThe ammonia (NH3) gas device sensors at room temperature rapid‐response (RTRR) selective discovery is a challenging and massive task that is restricted due to reduced room‐temperature (RT) detecting materials and their unsatisfactory gas detecting performance features. In this work, an organic small molecule 5, 10, 15, 20‐tetrakis {4‐[N,N‐di(4‐methoxyphenyl) amino‐phenyl]‐porphyrin (PO) and its cobalt complex cobalt‐porphyrin (PCo) based twisted type structure sensor is established for the detection of NH3 gas at RT. Interestingly, the introduction of Co atom into porphyin ring center increases overall performance, including high stability maximum response of 85% to 20 ppm NH3, and high selectivity towards ammonia compared to PO molecule. In terms of selectivity, the PCo sensor has a great affinity for NH3 due to the unpaired electron in dx2‐y2 with the porphyrin‐system, which boosts NH3 selectivity even in a mixture of gases. The detection range is 1 ppm, which is an 11% response with outstanding fast response (180 s) and recovery (10 s) containing excellent reproducibility to 20 ppm NH3. The superior gas‐detecting characteristics of PCo are ascribed to the interface between NH3 and cobalt Co‐group of PCo. The results from sequential studies deliver a novel approach and procedure for exploring RT ammonia gas device sensors.
Biocompatible and Nanoenabled Technologies for Biological Modulation
Authors: Ostroff Eleanor , Parekh Kavita , Prominski Aleksander , Tian Bozhi 
Published: June 2021

AbstractBiocompatible and nanoscale devices for biological modulation of cells and tissues possess the potential for tremendous impact on medical and industrial technologies. Typical medical devices and therapies tend to be macroscale, comprised of nonbiocompatible materials, and broadly targeted, resulting in imprecise treatments and adverse effects such as chronic immune response and tissue damage. The development of nanoenabled and biocompatible technologies—ranging from biodegradable nanoparticles for localized drug delivery to transient electronic devices for stimulation therapy to engineered biofilms with applications to nanomedicine—will continue to enable the advent of personalized medicine and precision therapies. In this review, recent research into this frontier is reviewed, first analyzing the synthesis of nanoenabled and biocompatible technologies and then presenting significant considerations regarding the development of such materials. Lastly, the latest advancements in biocompatible, nanoenabled devices are examined, followed by a discussion of the direction of future research in the field.
Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics
Authors: Xu Jiating , Wang Jun , Ye Jin , Jiao Jiao , Liu Zhiguo , Zhao Chunjian , Li Bin , Fu Yujie 
Published: June 2021

AbstractMetal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.
Unambiguous Tracking of Protein Phosphorylation by Fast High‐Resolution FOSY NMR**
Authors: Lesovoy Dmitry M. , Georgoulia Panagiota S. , Diercks Tammo , Matečko‐Burmann Irena , Burmann Björn M. , Bocharov Eduard V. , Bermel Wolfgang , Orekhov Vladislav Y. 
Published: June 2021

AbstractDysregulation of post‐translational modifications (PTMs) like phosphorylation is often involved in disease. NMR may elucidate exact loci and time courses of PTMs at atomic resolution and near‐physiological conditions but requires signal assignment to individual atoms. Conventional NMR methods for this base on tedious global signal assignment that may often fail, as for large intrinsically disordered proteins (IDPs). We present a sensitive, robust alternative to rapidly obtain only the local assignment near affected signals, based on FOcused SpectroscopY (FOSY) experiments using selective polarisation transfer (SPT). We prove its efficiency by identifying two phosphorylation sites of glycogen synthase kinase 3 beta (GSK3β) in human Tau40, an IDP of 441 residues, where the extreme spectral dispersion in FOSY revealed unprimed phosphorylation also of Ser409. FOSY may broadly benefit NMR studies of PTMs and other hotspots in IDPs, including sites involved in molecular interactions.
DNA‐Based Synthetic Growth Factor Surrogates with Fine‐Tuned Agonism**
Authors: Akiyama Momoko , Ueki Ryosuke , Yanagawa Masataka , Abe Mitsuhiro , Hiroshima Michio , Sako Yasushi , Sando Shinsuke 
Published: June 2021

AbstractDesigning synthetic surrogates of functional proteins is an important, albeit challenging, task in the field of chemistry. A strategy toward the design of synthetic agonists for growth factor or cytokine receptors that elicit a desired signal activity has been in high demand, as such ligands hold great promise as safer and more effective therapeutics. In the present study, we used a DNA aptamer as a building block and described the strategy‐guided design of a synthetic receptor agonist with fine‐tuned agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting fine‐tuned receptor signaling.
Expedient Synthesis of Bridged Bicyclic Nitrogen Scaffolds via Orthogonal Tandem Catalysis
Authors: Biswas Sovan , Van Steijvoort Ben F. , Waeterschoot Marjo , Bheemireddy Narendraprasad Reddy , Evano Gwilherm , Maes Bert U. W. 
Published: June 2021

AbstractBridged nitrogen bicyclic skeletons have been accessed via unprecedented site‐ and diastereoselective orthogonal tandem catalysis from readily accessible reactants in a step economic manner. Directed Pd‐catalyzed γ‐C(sp3)‐H olefination of aminocyclohexane with gem‐dibromoalkenes, followed by a consecutive intramolecular Cu‐catalyzed amidation of the 1‐bromo‐1‐alkenylated product delivers the interesting normorphan skeleton. The tandem protocol can be applied on substituted aminocyclohexanes and aminoheterocycles, easily providing access to the corresponding substituted, aza‐ and oxa‐analogues. The Cu catalyst of the Ullmann‐Goldberg reaction additionally avoids off‐cycle Pd catalyst scavenging by alkenylated reaction product. The picolinamide directing group stabilizes the enamine of the 7‐alkylidenenormorphan, allowing further product post functionalizations. Without Cu catalyst, regio‐ and diastereoselective Pd‐catalyzed γ‐C(sp3)‐H olefination is achieved.
Multifiller nanocomposites containing gadolinium oxide and bismuth nanoparticles with enhanced X‐ray attenuation property
Authors: Jayakumar Sangeetha , Mani Vadivel , Saravanan Thangavelu , Rajamanickam Karunanithi , Prabhu Alex Daniel , Philip John 
Published: June 2021

AbstractWe report here the development of multifiller nanocomposite containing gadolinium oxide and bismuth nanofillers with enhanced X‐ray attenuation property. The mass attenuation coefficient of the nanocomposite is found to be 5.26 (X‐ray attenuation: 95%) and 2.22 cm2/g (X‐ray attenuation: 71%), respectively, under dental and lung X‐ray scan conditions. Fourier transform infrared spectroscopy confirms the interfacial interaction between Gd2O3 nanofillers and the polymer matrix through hydrogen bonding. Atomic force microscopy images of the nanocomposite show a smooth and uniform topography with an average surface roughness of ~19 nm. Thermogravimetric analysis confirms the thermal stability of the nanocomposite upto 384°C. The enhanced X‐ray attenuation property of the nanocomposite is attributed to the good interfacial bonding, dual k‐edge effect of nanofillers and their uniform distribution within the polymeric matrix. Therefore, this nanocomposite is a promising material for diagnostic X‐ray shielding, especially as, thyroid collar, gonad shield, aprons, gloves, and so on.
Consensus‐based nonlinear smoother for distributed continuous‐discrete systems
Authors: Liu Dongmei , Wang Yanhui 
Published: June 2021

AbstractIn order to estimate the state of general distributed continuous‐discrete nonlinear system, a new consensus on the measurement and information cubature smoothing method is proposed in this article. The distributed continuous‐discrete nonlinear dynamic system refers to a system whose process is described as a stochastic differential equation (SDE) and whose measurements are provided by a wireless sensor network (WSN) at discrete times. First, the cubature rule is embedded into the consensus on measurements and information extended Kalman filter (CMIEKF) architecture by using the statistical linear regression (SLR) method, and then the presented consensus‐based method is obtained according to the Rauch–Tung–Striebel (RTS) smoothing methodology. In a numerical simulation, the performances of the presented smoothing method and the conventional nonlinear estimating methods are compared and analyzed. The numerical results show that, compared with other distributed estimation methods, the newly proposed smoothing algorithm enjoys not only higher accuracy but also stronger robustness.