bluuebunny/crossref_metadata_2025_split huggingface dataset:
Método Mãe Canguru: o cuidado compartilhado com a atenção primária em saúde
Authors: Alves Ana Carolina Alvim Pessoa , Souza Alessandra da Silva , Silva Jannaína Sther Leite Godinho , Alves Manoela , Silva Eliara Adelino da , Gomes Elisangela Nascimento Fernandes 
Published: August 2021

O Método Mãe Canguru (MMC) surgiu inicialmente na Colômbia com a proposta de melhorar os cuidados prestados ao recém‑nascido pré‑termo, tendo como intuito reduzir os custos da assistência perinatal e promover, através do contato pele a pele precoce entre a mãe e o seu bebê, maior vínculo afetivo, maior estabilidade térmica e melhor desenvolvimento. Nesta perspectiva, devido ao vazio literário de materiais detalhados, o presente estudo tem por objetivo identificar como se dá o cuidado ao recém-nascido pré-termo e sua família após a alta hospitalar, bem como seus desafios e dificuldades. Para tal, foi realizado uma revisão bibliográfica com abordagem qualitativa utilizando-se da busca de artigos científicos, guias e protocolos para expansão do conhecimento. Durante a revisão foram identificados aspectos relevantes a serem abordados, como: o preparo para a continuidade do método mãe canguru; a interface da 3ª etapa com a atenção básica; o enfermeiro como incentivador do método mãe canguru na atenção básica. Sabe-se que, inicialmente, as ações do MMC são centradas no cuidado hospitalar, no entanto, gradativamente há a construção de uma linha de cuidado que integra o trabalho da Unidade Neonatal à Atenção Básica, as quais devem ser grandes aliadas. Sendo assim, para que a assistência na APS seja efetiva, faz-se necessário que os profissionais sejam sensibilizados e capacitados para realizar as ações necessárias, por meio de uma assistência articulada que inclui os diversos níveis de saúde.
Palavras-chaves: Método Mãe Canguru; Terceira Etapa; APS.
As Repercussões Bio-Psíquicas do Parto Humanizado Sob a Lógica da Mulher
Authors: Duque Larissa de Medeiros , Silva Geisa Sereno Velloso da , Silva Jannaína Sther Leite Godinho , Alves Manoela , Silva Eliara Adelino da , Gomes Elisângela Nascimento Fernandes 
Published: August 2021

O parto humanizado traz como um dos seus objetivos a contemplação de todos os direitos da parturiente, desde a descoberta de sua gestação até o momento definitivo do parto. Trata-se de uma revisão integrativa que busca evidenciar a perspectiva da mulher sobre os benefícios do parto humanizado. A humanização do parto coloca a mulher como protagonista de todas as suas escolhas e dá a ela o direito de opinar sobre os detalhes que promovam a ela maior bem-estar físico e emocional. Constatou-se através deste estudo que muitos avanços ainda hão de ser feitos no campo de humanização do parto.
Palavras Chaves: Parto; Humanização, Enfermagem, Relação Enfermeiro-Paciente.
Systematic Optimisation of Microtiter Plate Lectin Assay to Improve
Sialic Acid Linkage Detection
Authors: Shahidan Muhammad Ashraf , Khairol Mokhtar Nur Hanina Izzati , Hussin Ainulkhir , Hamid Aidil Abdul , Zainal Ariffin Shahrul Hisham 
Published: August 2021

Aims:
We aimed to develop a high-throughput lectin assay with minimized background
signals to investigate the interactions of lectins and sialic acid glycans, focusing on Prostate-
Specific Antigen (PSA).

Background:
High background signals resulting from nonspecific binding are a significant
concern for microtiter plate-based Enzyme-Linked Lectin Sorbent Assays (ELLSAs), as they can
mask specific binding signals and cause false-positive results.

Methods:
In this study, we constructed an ELLSA based on different washing step parameters,
including the number of washing cycles, NaCl and Tween-20 concentrations, and the type of
blocking agent and evaluated the effects on both specific and nonspecific binding signals.
Furthermore, we performed a PSA binding assay using the optimized ELLSA.

Results:
The optimal washing parameters based on the highest specific binding signal proposed
four cycles of washing steps using a washing buffer containing a high salt concentration (0.5 M
NaCl) and mild detergent (0.05% Tween-20). The utilization of the optimized washing parameters
in this assay was shown to be sufficient to obtain the optimal binding signals without the use of any
blocking agent. Binding assays performed using the optimized ELLSA revealed that the glycan of
the PSA sample used in this study mainly consists of terminal α2,6-linked sialic acid, as strongly
recognized by Sambucus nigra agglutinin (SNA) with a KD value of 12.38 nM.

Conclusion:
The ELLSA reported in this study provides a simple yet sensitive assay for sialic acid
linkage recognition.
Changes in the Expression Pattern of DUSP1-7 and miRNA Regulating
their Expression in the Keratinocytes Treated with LPS and Adalimumab
Authors: Grabarek Beniamin Oskar , Dąbala Maciej , Kasela Tomasz , Gralewski Marcin , Gładysz Dorian 
Published: August 2021

Background:
Increased levels of phosphorylated ERK and p38 MAPK proteins have
been observed in psoriatic skin biopsies compared to controls, which may be associated with an
impaired expression pattern of dual activity protein phosphatase (DUSP).

Objective:
The purpose of this study was to assessment changes in expression profile of mRNA
DUSP 1-7 and miRNA regulating their expression in human keratinocyte cells (HaCaT) had exposed
to the liposaccharide A (LPS).

Methods:
HaCaT was exposed to 1 μg/ml LPS and next adalimumab by 2,8,24h compared to untreated
cells. The microarray method was used to analyze expression pattern of mRNAs, miRNAs,
and ELISA to evaluate changes in the level of the proteins. RTqPCR was used to validate the microarray
data. Transcriptome Analysis Console and Statistica Software 13 PL were used in statistical
analysis (p<0.05).

Results:
The highest changes in expression was observed for DUSP2 (FC +11.12) and DUSP5
(FC +5.53) in HaCaT culture after 2 hours exposition on adalimumab. It was observed that miR-
1275 (FC -2.39) and miR-34a (FC +6.52) might regulate level of DUSP2, and miR-27a (FC
+3.55), miR-27b (FC +2.87) are involved in DUSP5 expression.

Conclusion:
The results obtained suggest that DUSP2 and DUSP5 may be considered as complementary
molecular markers in the diagnosis and monitoring of the effectiveness of psoriasis therapy.
It was confirmed that hsa-miR-34a, hsa-miR-1275, hsa-miR-3188, hsa-miR-382, hsa-miR-
27a, hsa-miR-27b, hsa-miR-16 have the highest influence on the expression pattern of DUSP1-7.
A Case of Giant Cervical Polyp
Authors: Mutreja Dhaarna , Shetty Shraddha 
Published: August 2021

Introduction:
Introduction: Cervical polyps are small pedunculate, often sessile neoplasm of the
cervix. It is not known whether this is due to chronic inflammation, or abnormal local responsiveness
to hormonal stimulation, or localized vascular congestion of cervical blood vessels. They occur
most frequently in multiparous women in the fifth decade of life.

Case Description:
Here, we are reporting a case of a giant cervical polyp in a 38-year-old nulliparous
lady who reported heavy menstrual bleeding and mass per vagina.

Conclusion:
Since a giant cervical polyp can mimic chronic inversion of the uterus, cervical fibroid,
endometrial polyp, and cervical malignancy, it requires ruling out of these conditions before
GnRH therapy.
Risk of Accidents or Chronic Disorders From Improper Use of Mobile Phones: A Systematic Review and Meta-analysis
Authors: Cao Xinxi , Cheng Yangyang , Xu Chenjie , Hou Yabing , Yang Hongxi , Li Shu , Gao Ying , Jia Peng , Wang Yaogang 
Published: August 2021

Background
Mobile phone use has brought convenience, but the long or improper use of mobile phones can cause harm to the human body.

Objective
We aimed to assess the impact of improper mobile phone use on the risks of accidents and chronic disorders.

Methods
We systematically searched in PubMed, EMBASE, Cochrane, and Web of Science databases for studies published prior to April 5, 2019; relevant reviews were also searched to identify additional studies. A random-effects model was used to calculate the overall pooled estimates.

Results
Mobile phone users had a higher risk of accidents (relative risk [RR] 1.37, 95% CI 1.22 to 1.55). Long-term use of mobile phones increased accident risk relative to nonuse or short-term use (RR 2.10, 95% CI 1.63 to 2.70). Compared with nonuse, mobile phone use resulted in a higher risk for neoplasms (RR 1.07, 95% CI 1.01 to 1.14), eye diseases (RR 2.03, 95% CI 1.27 to 3.23), mental health disorders (RR 1.16, 95% CI 1.02 to 1.32), and headaches (RR 1.25, 95% CI 1.18 to 1.32); the pooled risk of other chronic disorders was 1.20 (95% CI 0.90 to 1.59). Subgroup analyses also confirmed the increased risk of accidents and chronic disorders.

Conclusions
Improper use of mobile phones can harm the human body. While enjoying the convenience brought by mobile phones, people have to use mobile phones properly and reasonably.
Exploring the Shift in International Trends in Mobile Health Research From 2000 to 2020: Bibliometric Analysis
Authors: Cao Jianfei , Lim Yeongjoo , Sengoku Shintaro , Guo Xitong , Kodama Kota 
Published: August 2021

BackgroundSmartphones have become an integral part of our lives with unprecedented popularity and a diverse selection of apps. The continuous upgrading of information technology has also enabled smartphones to display great potential in the field of health care.ObjectiveWe aimed to determine the future research direction of mobile health (mHealth) by analyzing its research trends and latest research hotspots.MethodsThis study collected mHealth-related literature published between 2000 and 2020 from the Web of Science database. Descriptive statistics of publication trends of mHealth research were determined by analyzing the annual number of publications in the literature and annual number of publications by country. We constructed visualization network maps of country (or regional) collaborations and author-provided keyword co-occurrences, as well as overlay visualization maps of the average publication year of author-provided keywords to analyze the hotspots and research trends in mHealth research.ResultsIn total, 12,593 mHealth-related research papers published between 2000 and 2020 were found. The results showed an exponential growth trend in the number of annual publications in mHealth literature. JMIR mHealth and uHealth, the Journal of Medical Internet Research, and JMIR Research Protocols were the 3 top journals with respect to number of publications. The United States remained the leading contributor to the literature in this area (5294/12,593, 42.0%), well ahead of other countries and regions. Other countries and regions also showed a clear trend of annual increases in the number of mHealth publications. The 4 countries with the largest number of publications—the United States, the United Kingdom, Canada, and Australia—were found to cooperate more closely. The rest of the countries and regions showed a clear geographic pattern of cooperation. The keyword co-occurrence analysis of the top 100 authors demonstrated 5 clusters, namely, development of mHealth medical technology and its application to various diseases, use of mHealth technology to improve basic public health and health policy, mHealth self-health testing and management in daily life, adolescent use of mHealth, and mHealth in mental health. The research trends revealed a gradual shift in mHealth research from health policy and improving public health care to the development and social application of mHealth technologies.ConclusionsTo the best of our knowledge, the most current bibliometric analysis dates back to 2016. However, the number of mHealth research published between 2017 and 2020 exceeds the previous total. The results of this study shed light on the latest hotspots and trends in mHealth research. These findings provide a useful overview of the development of the field; they may also serve as a valuable reference and provide guidance for researchers in the digital health field.
Productivity and profitability of peanut at various land suitability in North Lombok Regency of Nusa Tenggara Barat Province
Authors: Suriadi Ahmadi , Zulhaedar Fitria , Nazam Moh. 
Published: August 2021

Peanuts (Arachis hypogaea L.) are the second main commodity in the annual cropping pattern in lowland and dryland in North Lombok District of NTB Province. However, peanut productivity is still low, and it varies across regions, which might be due to the traditional crop management of farmers and the difference in land suitability classes. Effects of crop varieties and land suitability on the peanut productivity have not been evaluated in the Region. Thus, this study aimed to evaluate the productivity and profitability of peanut varieties at various land classification in KLU NTB. The experiment was arranged in a Split Plot Design consisting of three classes of land suitability as main plot and six peanut varieties as sub-plot with three replications. The results showed that the land suitability classes have a significant effect on the agronomic variables of peanut varieties, including plant height, number of branches, number of pods and productivity. The highest peanut yield was obtained at suitable land class (S1), followed by moderately suitable land class (S2) and marginally suitable land class (S3) at 2.37 ton.ha-1, 2.08 ton.ha-1 and 1.71 ton.ha-1, respectively. Likewise, the R/C ratio follows a similar pattern to productivity in various land suitability classes. The highest yield (above 2 ton.ha-1) in each land suitability class was produced by Kelinci variety, followed by Tuban, Bima and Talam varieties. Those varieties have potential prospective to be developed in North Lombok Regency.
Women's Roles In Adding Value To Wooden Crafts And Contributing To Family Income In Babung, Gunungkidul
Authors: Subiyantoro Slamet 
Published: August 2021

Gender discrimination continues to exist in the Special Region of Yogyakarta, with women often placed in the role of mother and housekeeper. In areas such as Bobung Village, where they form an integral part of the local industry, women transcend these roles to contribute to the economy. This research aimed to examine women's roles in adding to the artistic value of wooden crafts, their impact on increasing family income, and local community members’ views towards these female roles. The research was socio-anthropological, with data obtained through in-depth interviews, participant observations, and content analyses of documents and records. Data were analyzed using an interactive model including data collection, reduction of presentation, and verification. The findings showed that (1) women play a significant role in improving the artistic value of wooden crafts through their batik painting and writing techniques. They make these crafts appear more exotic, and help to preserve traditional batik motifs. (2) With the addition of these women’s motifs to wooden crafts, they add to their family income while still performing their domestic duties, such as caring for their children and cooking. Their wages are based on a daily system, collective system, or combination of both. (3) Batik-making on wooden crafts has feminine characteristics; it is soft and light, as opposed to woodworking’s masculine characteristics of hard, physical work. Women’s batik-making is consequently complementary to the work performed by men. According to the local people, there is no gender bias related to the job differentiation between men and women.
Women in Mount Tengger Folklores: Their Presence, Position and Environmental Knowledge of Disaster Mitigation
Authors: Sukmawan Sony , Setyowati Lestari 
Published: August 2021

Tenggerese people in East Java are one of Indonesia’s ethnic communities endowed with a unique folklore. This ethnographic research aimed to find out 1) how women are presented in Mount Tengger folklore; 2) the position of women in Tengger folkore; and 3) Tenggerese women’s environmental knowledge in relation to nature and disaster mitigation. Data analysis used multi perspective dimensions by employing theories of ecofeminism, ecocriticism, and folkloristic views. Human instruments, observations, interviews, and documentation were used in this study. The findings revealed that 1) women are presented both in Tengger folktales and oral poetry (spells), and are characterized as being mentally strong, respected, and having the proclivity to protect the environment. 2) In Tenggerese folklore, women enjoy equal position with men. The equality between men and women has become a social value and practice within Tenggerese traditions. Women work side-by-side with men in their domestic lives and beyond. 3) Tenggerese women have extensive environmental knowledge, in both the physical and psychological sense. They have in-depth and detailed knowledge of the vitality of nature for human living.
MYTH AND FOLKLORE EMBODIMENT IN THE FEMALE PROTAGONISTS OF CONTEMPORARY FICTIONS: A READING OF THE SHIVA TRILOGY AND BULBBUL
Authors: L RAVEENDRAN PRASADITA 
Published: August 2021

The collective consciousness of a community is tremendously shaped by myths and folktales passed on from generation to generation. With the publication of Joseph Campbell's book The Hero with a Thousand Faces, the idea of the hero and his journey took a giant leap, allowing the commoner's life narratives to be equated with the mythical journey. This study analyzes how mythology is demythified and symbolically represented in two of India's famous narratives, a novel series Shiva Trilogy by Amish Tripathi and an “over-the-top” (OTT) film Bulbbul by Anvita Dutt. The objects of this research are Indian mythological narratives about Goddess Shakti and her various manifestations — Durga, Kali, Sati, and Parvati — whose respective nature and purpose differ vastly from one another. Through the qualitative research method, the paper shows that the reader/viewer has well-received the interweaving of myth with contemporary fiction. It has given way to a change in diegesis, from the predominantly male-hero-focused outline to a female-driven narrative. The myth-bound heroines thus represent the power to break the shackles of patriarchy and normative culture, allowing an area for women to radicalize themselves through bold actions. Kesadaran kolektif suatu komunitas sangat bergantung pada mitos dan cerita rakyat yang diturunkan dari generasi ke generasi. Dengan diterbitkannya The Hero with a Thousand Faces karya Joseph Campbell, gagasan tentang pahlawan dan perjalanannya memungkinkan narasi kehidupan orang biasa untuk disejajarkan dengan perjalanan mitos. Studi ini bertujuan untuk menganalisis bagaimana mitologi didemistifikasi dan secara simbolis direpresentasikan dalam dua narasi terkenal India, yakni serial novel Shiva Trilogy karya Amish Tripathi dan film “over-the-top” (OTT) Bulbbul karya Anvita Dutt. Objek penelitian ini adalah narasi mitologi India tentang Dewi Shakti dan berbagai manifestasinya — Durga, Kali, Sati, dan Parvati — yang sifat dan tujuannya masing-masing sangat berbeda satu sama lain. Melalui metode penelitian kualitatif, ditemukan; 1) pembaca/pemirsa telah menerima dengan baik jalinan mitos dengan fiksi kontemporer; 2) memberi jalan pada perubahan diegesis, dari garis besar yang berfokus pada pahlawan pria menjadi narasi yang digerakkan oleh wanita; 3) para tokoh wanita yang terikat mitos, mematahkan belenggu patriarki dan budaya normatif, memungkinkan area bagi perempuan untuk meradikalisasi diri mereka sendiri melalui tindakan yang berani.
SULFASALAZINE ATTENUATES ULCERATIVE COLITIS IN RATS VIA DOWNREGULATION OF MIRNA-31, METALLOPROTEINASE-3 AND HIGH MOBILITY GROUP BOX1
Authors: BOSHRA SYLVIA A. 
Published: August 2021

Objective: This study targets the inhibition of inflammatory mediators and the enhancement of gastrointestinal mucosa healing in ulcerative colitis in rats through sulfasalazine.
Methods: Twenty four female albino rats were divided into 3 groups: normal control, colitis group (rats received 5% dextran sodium sulfate (DSS) in their drinking water for 7 d), sulfasalazine group (500 mg/kg/day was administrated orally one week ahead of DSS and parallel with its administration). The impact of sulfasalazine on intestinal inflammation was investigated via estimation of some inflammatory mediators, namely; serum Leucine rich α 2 Glycoprotein (LRG) as well as colon cAMP, Myloperoxidase (MPO) and TNF-α using ELISA technique as well as gene expression of Trefoil Factor 3 (TFF3), High mobility group box1 (HMGB1), Nuclear factor kappa B (NF-κB) and metalloproteinase-3 (MMP3) and miRNA-31 levels using RT-PCR.
Results: Sulfasalazine substantially decreases the release of LRG, MPO and TNF-α and the expression of HMGB1, NF-κB, MMP3, TFF3 and miRNA31 at p≤ 0.05 compared to colitis group in vivo. Moreover, Sulfasalazine significantly increases the colonic cAMP at p≤ 0.05 in groups of rats treated with DSS.
Conclusion: Sulfasalazine has a protective effect on inflammatory bowel disease causing mucosal healing within the gastrointestinal tract. Additional studies are warranted to explore the molecular mechanism of sulfasalazine in ulcerative colitis and its clinical application.
Eventos adversos en recién nacidos hospitalizados en una Unidad de Cuidados Intermedios
Authors: Chumpitaz-Chávez Y. , Gutiérrez-Crespo H. , Matzumura-Kasano J. , Ruíz-Arias R.A. 
Published: August 2021

Introducción: Los recién nacidos (RN) conforman uno de los grupos poblacionales más vulnerables. El riesgo de ocurrencia de un evento adverso durante su hospitalización se incrementa por diversos factores.
Objetivo: Identificar los eventos adversos en recién nacidos hospitalizados en una unidad de cuidados intermedios en 2018.
Metodología: Estudio de tipo descriptivo, diseño transversal y retrospectivo, realizado en la Unidad de Cuidados Intermedios Neonatales del Instituto Nacional Materno Perinatal durante el 2018. Se elaboró una ficha de recolección de datos que constó de nueve ítems correspondientes a procedimientos realizados por el personal de enfermería. Se utilizó un análisis univariado de los datos, presentados en tablas y gráficos.
Resultados: Fueron analizados 73 eventos adversos, la menor edad gestacional fue de 32 semanas, con un máximo de 28 días de hospitalización. 60% de eventos se produjo en los RN más lábiles y con situación de salud compleja, de los cuales, 58% fueron infecciones asociadas a catéter percutáneo o periférico, cuyo germen frecuente fue Sthapylococcus coagulasa negativo. Solo 20.5% de eventos adversos fueron reportados.
Discusión: Los resultados obtenidos coinciden con otras investigaciones en que los factores intrínsecos de los recién nacidos contribuyen en la aparición de eventos adversos; de igual manera, concuerdan en la necesidad de prevenirlos y notificarlos.
Conclusiones: La prematuridad, el tiempo de hospitalización en una unidad crítica y de exposición a diversos procedimientos, incrementaron el riesgo de ocurrencia de eventos adversos en recién nacidos. Detectar oportunamente estos acontecimientos, así como fomentar la cultura de reporte, con el fin de evitarlos.