bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Vanadium and Sulfur Containing Compounds of Kazakhstan Petroleum Vacuum Residuum
Authors: Ongarbayev Yerdos , Oteuli Shynar , Tileuberdi Yerbol , Zhang Yahe , Zheng Fang , Shi Quan 
Published: August 2021

In the paper, bulk property and chemical composition of Kazakhstan vacuum residuum were characterized. Sulfides and thiophenes were selectively isolated from the residuum and characterized by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Molecular weights of the sulfur compounds were varied from 150 to 800 Da and S1 , S2 , O1S1 , O2S1 , N1S1 class species were assigned in the heavy oil derived methylsulfonium. Vanadyl porphyrins characterized by positive-ion electrospray ionization and FT-ICR MS, which showed that etioporphyrins (ETIO) (CnH2n-28N4V1O1 , corresponding to DBE = 17) and deoxophylloerythroetioporphyrins (DPEP) (CnH2n-30N4V1O1, corresponding to DBE = 18). It should be noted that the vanadyl porphyrins were most abundant.
Penanganan Tanah Lunak pada Timbunan Tinggi di Area Akses Rancakalong Sta. 0+675 – Sta. 0+775 Jalan Tol Cisumdawu
Authors: Yogaswara Dendi 
Published: July 2021

Jalan Tol Cisumdawu merupakan salah satu proyek strategis nasional yang menghubungkan daerah Cileunyi-Sumedang dan Cirebon daerah Dawuan. Pada Jalan Akses Rancakalong Sta. 0+675 – 0+775 yang merupakan rangkaian pembangunan jalan tol Cisumdawu, berada pada tata guna lahan palawija dan dalam arah memanjang jalan lokasi ini merupakan daerah cekungan. Namun merujuk pada gambar desain konstruksi pada Sta. 0+675 – 0+700 merupakan daerah timbunan cukup tinggi dan tanpa perkuatan. Penelitian dilakukan untuk mengetahui stabilitas desain timbunan berdasarkan faktor keamanan dari timbunan menggunakan metode elemen hingga. Hasil yang didapatkan pada penelitian ini didapatkan pada kaki timbunan sebelah kiri diperkuat dengan kombinasi bored pile dengan dinding beton kantilever sedangkan pada kaki timbunan sebelah kanan diperkuat dengan kombinasi bored pile dengan gabion. Dengan perkuatan timbunan tersebut didapatkan nilai faktor keamanan timbunan sebesar 1.38.
The Main Refrigeration Compressor di KM. Sabuk Nusantara 37 pada PT. Pelni
Authors: Erita Erita , Darza Syefli Ewimia , Kurniawan Ade Putra , Nofrizal Nofrizal 
Published: August 2021

Dengan semakin berkembangnya teknologi serta kemajuan zaman pada saat ini ternyata sistem pendingin banyak memberikan keuntungan bagi manusia yang secara tidak sadar mungkin dapat kita rasakan selama ini. sistem pendinginan pada umumnya banyak digunakan untuk kepentingan industri dan komersial. Pada saat ini Refrigeration merupakan salah satu alat yang peranannya dalam kehidupan manusia saat ini bisa dibilang cukup besar. Refrigeration digunakan untuk menyimpan bahan-bahan makanan, sayuran bahkan buah-buahan. Penelitian dilakukan terhadap masalah atau kerusakan-kerusakan yang terjadi pada refrigeration di kapal KM Sabuk Nusantara 37 pada PT Pelni. Jenis penelitian yang digunakan dalam penulisan skripsi ini adalah jenis penelitian deskriptif, dengan menggunakan pendekatan kualitatif. Analisis data dilakukan dengan mengunakan metode deskriptif, yaitu metode yang dilakukan dengan terlebih dahulu mengumpulkan data yang ada kemudian diklasifikasikan, selanjutnya diinterprestasikan sehingga dapat memberikan pemecahan terhadap permasalahan. 8 masalah yang paling sering terjadi pada sistem refigeration di kapal KM. Sabuk Nusantara 37 yaitu kompressor jalan tapi berhenti tiba-tiba, Compressor terlalu sering start dan stop, Kompresor jalan terus menerus, Suara yang tidak biasa pada kompresor, Tingginya Temperatur Discharge, Bunga Es pada Evaporator, Kemampuan untuk mendinginkan yang berkurang, Berkurangnya oli dalam kompressor.
MANAJEMEN KESISWAAN DAN BIMBINGAN KONSELING DALAM PERSPEKTIF PENDIDIKAN KARAKTER
Authors: Chamidi Agus Salim 
Published: August 2021

Management of students and guidance and counceling becomes one important component in management of school/madrasah. It becomes very important when it is associated with the character learning in Indonesia nowadays. This writing tries to explain them through one aspect of management, that is planning. Planning in recruiting new students is so important and vital as a part of process of management of students and guidance and counceling in school/madrasah. All activities associating with recruiting new students, both management and administrative, becomes like a success key at first for process of school/madrasah management sustainably.
Keywords: management of students, management guidance and couceling, character learning, planning.
Два поховання культури кулястих амфор з урочища Заболоття-3 (археологічний та антропологічний аспекти)
Authors: Dolzhenko Yuriy , Tkach Vitalii 
Published: August 2021

У статті досліджується черепи та довгі кістки верхніх і нижніх кінцівок двох чоловіків із поховань культури кулястих амфор, знайдених під час науково-рятівних розкопок стихійного кар’єру в Дубенському районі – Заболоття-3 та середні розміри загальної вибірки чоловічих черепів людей культури кулястих амфор (ККА) з Волині (Заболоття-3 і с. Івання). Поховання оригінальні для ККА Волині та Поділля, тоді як традиційними є потужні кам’яні гробниці. Перспективним буде долучити до внутрішньогрупового аналізу індивідуальні дані чоловічих черепів ККА і культури шнурової кераміки України, Німеччини, Польщі, Чехії й об’єднати в одну групу ККА України та порівняти її з синхронними серіями Західної Європи.
Нормативно-правове забезпечення соціальної політики радянської влади щодо воїнів-«афганців» і членів їхніх сімей у 1980-х рр.
Authors: Ostrovyk Dmytro 
Published: August 2021

У статті розглянуто хронологію нормативно-правової регламентації окремих складових соціального забезпечення щодо визначених у Постановах ЦК КПРС і РМ СРСР від 1983 і 1984 рр., а також РМ СРСР від 1988 р. категорії осіб з числа радянських військовослужбовців – учасників бойових дій в Афганістані та членів їхніх сімей. Головним чином – стосовно осіб офіцерського складу, прапорщиків і мічманів, військовослужбовців строкової та надстрокової служб, що зазнавали каліцтв, інвалідності, а також сімей військовослужбовців, що гинули, або вмирали внаслідок отриманих в Афганістані захворювань – дружин, дітей і непрацездатних батьків.
Соціальний портрет радянської сім’ї
Authors: Gumeniuk Oksana 
Published: August 2021

Дослідження охоплює проміжок часу, обумовлений пануванням радянської влади на українських землях і (нерідко) у свідомості українців. Мета статті: визначення особливостей становлення сімейної політики радянської влади та співіснування приватного та загальнодержавного у побутовому просторі радянської сі’ї часів існування СРСР.
Подано порівняльний аналіз існування радянських сімей у різні часи існування радянської системи. Проведено частково паралелі між традиційною українською родиною у дореволюційний період і сімейними нововведеннями радянського періоду. Вказано на особливе значення ролі партії у житті радянської людини, що нерідко стосувалося і сімейно-шлюбного життя.
Мемуари гірничих інженерів донецького басейну другої половини ХІХ – початку ХХ ст.: професійний аспект
Authors: Otzemko Olena 
Published: August 2021

У статті розкрито інформаційний потенціал спогадів гірничих інженерів О. Ауербаха, О. Феніна, О. Терпигорєва, які працювали на рудниках Донбасу в другій половині ХІХ – на початку ХХ ст. Зосереджено увагу на професійному аспекті мемуарів, який включає технічні характеристики вугільних родовищ і рудників, питання організації гірничопромислового виробництва, розповіді про колег і підприємців з акцентом на професійних якостях, досить великі сюжети, присвячені шахтарям. Зазначається, що особливості біографій авторів і різні умови створення мемуарів спричинили відмінності у сприйнятті історичного контексту та віддзеркаленні спільних професійних сюжетів.
Леонід Миколайович Беркут: етапи творчого шляху вченого
Authors: Nalivaiko Andrey 
Published: August 2021

У статті розкрито етапи творчого шляху українського історика, педагога, професора, викладача Київського, Варшавського та Донського університетів, видатного дослідника західноєвропейського середньовіччя – Леоніда Миколайовича Беркута (1879-1940).
Це був один з найкращих інтелектуалів свого часу. Наукові закордонні студії сприяли становленню Л. Беркута як видатного вченого та широкого популяризатора історичних знань в Україні.
На жаль, через різні життєві обставини вчений надовго був вилучений з радянського інтелектуального простору, а його наукова спадщина була забута.
Труд музеографа: підготовка музейного видання в Україні (кінець ХІХ – перша третина ХХ століття)
Authors: Cherhik Nataliia 
Published: August 2021

У статті проаналізовані українські музейні видання кінця ХІХ – першої третини ХХ ст. з точки зору підготовки авторами музеографічних текстів. Приділено увагу об’ємам опрацювання музейних колекцій та особливостям роботи над укладанням каталогів, путівників, альбомів, описів, музейних звітів, музейних збірників. Представлена широта ерудиції осіб, долучених до публіцистично-поліграфічної діяльності українських музеїв зазначеного періоду.
Immunological Value of Prognostic Signature Based on Cancer Stem Cell Characteristics in Hepatocellular Carcinoma
Authors: Xu Qianhui , Xu Hao , Chen Shaohuai , Huang Wen 
Published: August 2021

Background: Liver cancer stem cells, characterized by self-renewal and initiating cancer cells, were decisive drivers of progression and therapeutic resistance in hepatocellular carcinoma (HCC). However, a comprehensive understanding of HCC stemness has not been identified.Methods: RNA sequencing information, corresponding clinical annotation, and mutation data of HCC were downloaded from The Cancer Genome Atlas-LIHC project. Two stemness indices, mRNA expression-based stemness index (mRNAsi) and epigenetically regulated-mRNAsi, were used to comprehensively analyze HCC stemness. Estimation of Stromal and Immune Cells in Malignant Tumors using Expression Data and single-sample gene-set enrichment analysis algorithm were performed to characterize the context of tumor immune microenvironment (TIME). Next, differentially expressed gene (DEG) analysis and weighted gene co-expression network analysis (WGCNA) were employed to identify significant mRNAsi-related modules with hub genes. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment pathways were analyzed to functionally annotate these key genes. The least absolute shrinkage and selection operator (LASSO) Cox regression analysis was performed to establish a prognostic signature. Kaplan–Meier survival curves and receiver operating characteristic (ROC) analysis were applied for prognostic value validation. Seven algorithms (XCELL, TIMER, QUANTISEQ, MCPcounter, EPIC, CIBERSORT, and CIBERSORT-ABS) were utilized to draw the landscape of TIME. Finally, the mutation data were analyzed by employing “maftools” package.Results: mRNAsi was significantly elevated in HCC samples. mRNAsi escalated as tumor grade increased, with poor prognosis presenting the higher stemness index. The stemness-related (greenyellow) modules with 175 hub genes were screened based on DEGs and WGCNA. A prognostic signature was established using LASSO analysis of prognostic hub genes to classify samples into two risk subgroups, which exhibited good prognostic performance. Additionally, prognostic risk-clinical nomogram was drawn to estimate risk quantitatively. Moreover, risk score was significantly associated with contexture of TIME and immunotherapeutic targets. Finally, potential interaction between risk score with tumor mutation burden (TMB) was elucidated.Conclusion: This work comprehensively elucidated that stemness characteristics served as a crucial player in clinical outcome, complexity of TIME, and immunotherapeutic prediction from both mRNAsi and mRNA level. Quantitative identification of stemness characteristics in individual tumor will contribute into predicting clinical outcome, mapping landscape of TIME further optimizing precision immunotherapy.
Cardio-Oncology Educational Program: National Survey as the First Step to Start
Authors: Kozhukhov Sergey , Dovganych Nataliia 
Published: August 2021

Aim: The collaboration of cardiologists, general practitioners (GPs), and oncologists is crucial in cancer patient management. We carried out a national-based survey—The Ukrainian National Survey (UkrNatSurv)—on behalf of the Cardio-Oncology (CO) Working Group (WG) of the Ukrainian Society of Cardiology to analyze the level of knowledge in cardio-oncology.Methods: A short questionnaire was presented to specialists involved in the management of cancer patients across the country. The questionnaire was made up of eight questions concerning referred cancer patient number, CV complications of cancer therapy, diagnostic methods to detect cardiotoxicity, and drugs used for its treatment.Results: A total of 426 questionnaires of medical specialists from different regions of Ukraine were collected and analyzed; the majority of respondents were cardiologists (190), followed by GPs (177), 40 oncologists (mainly chemotherapists and hematologists), other −19 (imaging specialists, neurologists, endocrinologists, etc.). All responders were equally involved in the management of cancer patients. However, less than half of the patients have been seen before the start of cancer therapy. GPs observe the majority of patients after the end of treatment. All doctors are sufficiently aware of cancer therapy-associated CV complications. However, the necessary diagnostic tools, mostly biomarkers, are not used widely by different specialists. The criteria for cardiotoxicity, in particular, the level of reduction of the left ventricular ejection fraction (LVEF) as a marker of LV dysfunction, are not clearly understood. The specific knowledge in the management of CV complications in cancer is required.Conclusion: UkrNatSurv is the first survey in Ukraine to investigate the awareness of CO care provided to cancer patients with CV diseases (CVD) or developed CV complications. Providing such surveys among doctors involved in CO is an excellent tool to investigate the knowledge gaps in clinical practice. Therefore, the primary task is to develop a national educational CO program.
Low-Voltage Zones as the Atrial Fibrillation Substrates: Relationship With Initiation, Perpetuation, and Termination
Authors: Liu Zheng , Xia Yu , Guo Changyan , Li Xiaofeng , Fang Pihua , Yin Xiandong , Yang Xinchun 
Published: August 2021

Background: Low-voltage zones (LVZs) were usually targeted for ablation in atrial fibrillation (AF). However, its relationship with AF initiation, perpetuation, and termination remains to be studied. This study aimed to explore such relationships.Methods: A total of 126 consecutive AF patients were enrolled, including 71 patients for AF induction protocol and 55 patients for AF termination protocol. Inducible and sustainable AF were defined as induced AF lasting over 30 and 300 s, respectively. Terminable AF was defined as those that could be terminated into sinus rhythm within 1 h after ibutilide administration. Voltage mapping was performed in sinus rhythm for all patients. LVZ was quantified as the percentage of the LVZ area (LVZ%) to the left atrium surface area.Results: The rates of inducible, sustainable, and terminable AF were 29.6, 18.3, and 38.2%, respectively. Inducible AF patients had no significant difference in overall LVZ% compared with uninducible AF patients (10.2 ± 11.8 vs. 8.5 ± 12.6, p = 0.606), while sustainable and interminable AF patients had larger overall LVZ% than unsustainable (16.2 ± 11.5 vs. 0.5 ± 0.7, p &lt; 0.001) and terminable AF patients (44.6 ± 26.4 vs. 26.3 ± 22.3, p &lt; 0.05), respectively. The segmental LVZ distribution pattern was diverse in the different stages of AF. Segmental LVZ% difference was initially observed in the anterior wall for patients with inducible AF, and the septum was further affected in those with sustainable AF, and the roof, posterior wall, and floor were finally affected in those with interminable AF.Conclusions: The associations between LVZ with AF initiation, perpetuation, and termination were different depending on its size and distribution.
Heterogeneity in Price Elasticity of Medicine Demand in China: Moderate Effect From Economic Incentive and Quality Difference
Authors: Zhao Mingyue , Nie Peng , Wu Jing 
Published: August 2021

Objectives: Previous studies have shown a wide range of drug price elasticity, but the price response to demand among various therapeutic drug categories and drug types (generic/originator) is still unexplored in China. This study estimates the price elasticity of medicine demand with regard to quality differences, unfair competition, and a regulated market.Methods: Product-level data on anti-tumor, cardiovascular disease (CVD), and antimicrobial drugs were collected from the Tianjin Urban Employees’ Basic Medical Insurance database (2008–2010). The moderating effects of quality, profit incentive, and illegal rebates are considered in a dynamic panel model.Findings: Our results suggest that the price elasticity of drug demand varies across drug categories, with least elasticity for anti-tumor drugs and most elasticity for CVD drugs (−0.192 for anti-tumor drugs vs. −0.695 for antimicrobials vs. −1.100 for CVD drugs, p &lt; 0.01). Moreover, the absolute value of price elasticity of generic drugs is higher than that of originator drugs in anti-tumor and CVD therapeutic classes (interact: 0.716 for anti-tumor; -0.630 for CVD, p &lt; 0.001). We believe that quality difference plays a dominant role in the interaction between quality and illegal rebates for these two kinds of generic drugs. In the antimicrobial sub-group, the absolute value of price elasticity of generic medicine is lower than that of originator drugs. We believe that, owing to the high level of unfair competition among enterprises, the role of illegal kickbacks is dominant, which reduces the price elasticity of demand for generic antimicrobial drugs.Conclusion: Our study provides an overview of the result of interaction between quality and illegal rebates in different medicine markets in China and shows that disease type is a primary factor that impacts price elasticity.
Stress and Coping in Youth With Spina Bifida: A Brief Longitudinal Study in a Summer Camp Setting
Authors: Ohanian Diana M. , Kritikos Tessa K. , Clark Olivia E. , Shirkey Kezia C. , Starnes Meredith , Holmbeck Grayson N. 
Published: August 2021

IntroductionIt is well established that youth with chronic conditions experience elevated levels of stress; the manner in which they respond to or cope with this stress is likely to impact both health and psychosocial outcomes. The current study examined stress and coping in youth and young adults with spina bifida (SB) using the response to stress questionnaire-SB version (RSQ-SB; Connor-Smith et al., 2000).MethodsData were collected as part of a camp-based psychosocial intervention for children (ages 7–13), adolescents (ages 14–19), and young adults (ages 20–38) with SB. Participants completed the RSQ-SB as well as questionnaires assessing demographics and condition severity. Data were collected prior to camp (T1) and 1 month (T2) after camp ended. Self-report data were collected from adolescents and young adults; parents of children and adolescents reported on their child’s stress and coping. Ratios of primary control coping, secondary control coping, disengagement coping, involuntary engagement, and involuntary disengagement coping were calculated. Descriptive statistics and t-tests were utilized to describe coping and stress responses and to determine potential change over time. T-tests were also used to compare youth and parent reported coping styles with those of youth with type 1 diabetes (T1D) and sickle cell disease (SCD). Associations between demographic/disease factors and coping styles were also examined.ResultsParent and youth report indicated that youth with SB tend to use primary control coping. Youth with SB use more primary control coping and less disengagement coping compared to youth with SCD and youth with T1D. Few significant changes in coping were found between T1 and T2. IQ and socioeconomic status were significantly associated with coping styles.ConclusionYouth with SB use more primary control coping compared to other coping methods and as compared to other pediatric populations. Future studies should examine mechanisms by which primary control coping is advantageous for youth with SB. Future interventions should be more focused on promoting adaptive coping behaviors and be tailored to developmental age and access to resources.
Microbiological and Clinical Aspects of Raoultella spp.
Authors: Appel Tobias M. , Quijano-Martínez Natalia , De La Cadena Elsa , Mojica María F. , Villegas María Virginia 
Published: August 2021

The genus Raoultella was established in 2001. Species of Raoultella and Klebsiella share many ecological, biochemical, clinical, and microbiological features. Given the shortcomings of available technology for species identification in the clinical microbiology laboratory, are practically indistinguishable. Since the late 2000s there has been an increase in case reports of human Raoultella infections. Therefore, several authors are postulating that Raoultella spp. are rare and/or emerging pathogens.Conclusions:Raoultella spp. are very similar to Klebsiella spp. The epidemiology and the clinical relevance of the human Raoultella spp. infections is uncertain and further studies are required. The previous difficulties in the identification of Raoultella spp. and the introduction of more precise identification techniques may explain the recent increase in the number of case reports. Raoultella spp. might be rather underdiagnosed than rare or emerging pathogens.
Expression of Cathepsins B, D, and G in Extracranial Arterio-Venous Malformation
Authors: Hansen Lauren , Brasch Helen D. , Paterson Erin , Patel Josie , Bockett Nicholas , Davis Paul F. , Tan Swee T. 
Published: August 2021

Objectives: We have previously identified a population of cells that expressed stemness-associated markers in extracranial arterio-venous malformation (AVM) and demonstrated expression of cathepsins B, D, and G on embryonic stem cell (ESC)-like populations in other vascular anomalies. This study investigated the expression of cathepsins B, D, and G, and their localization in relation to this primitive population in extracranial AVM.Methods: Immunohistochemical staining was performed on AVM tissue samples from 13 patients to demonstrate expression of cathepsins B, D, and G. Western blotting was performed on four AVM tissue samples and three AVM-derived primary cell lines to confirm protein expression of cathepsins B and D proteins. RT-qPCR was performed on three AVM-derived primary cell lines to demonstrate transcript expression of cathepsins B, D, and G. Enzymatic activity assays were performed on three AVM-derived primary cell lines to investigate if cathepsins B and D were active. Localization of the cathepsins was investigated using immunofluorescence dual-staining of the cathepsins with the ESC markers OCT4 and SOX2, and mast cells marker chymase on two of the 13 AVM tissue samples.Results: Immunohistochemical staining demonstrated expression of cathepsins B, D, and G in all 13 AVM tissue samples. Western blotting showed expression of cathepsins B and D proteins in all four AVM tissue samples and all three AVM-derived primary cell lines. RT-qPCR demonstrated transcripts of cathepsins B, D, and G in all three AVM-derived primary cell lines. Enzymatic activity assays showed that cathepsins B and D were active. Immunofluorescence staining showed expression of cathepsins B and D on the OCT4+/SOX2+ endothelium and media of the lesional vessels and cells within the stroma in AVM nidus. Cathepsin G was expressed on the chymase+ phenotypic mast cells.Conclusions: This study demonstrated the novel finding of the expression of cathepsins B, D, and G in AVM. Cathepsins B and D were expressed by the primitive population, and cathepsin G was localized to mast cells, within the AVM nidus.