bluuebunny/crossref_metadata_2025_split huggingface dataset:
El aprendizaje de las técnicas individuales del voleibol: una experiencia desde las actividades lúdicas
Authors: Álava Párraga Gabriela Maricela 
Published: November 2021

Introducción. La enseñanza-aprendizaje de los diferentes deportes en el contexto de la Educación Física Escolar, constituye un tema fundamental, de ahí que en el Currículo de Educación Física en Ecuador integre dentro del bloque curricular Prácticas Deportivas, el proceso de enseñanza-aprendizaje de varios deportes, siendo el Voleibol uno de los deportes que los estudiantes deben aprender. En observación realizada en la Unidad Educativa Eloy Alfaro" del Cantón Chone, específicamente en el 10mo año de Enseñanza General Básica, se pudo detectar limitaciones en el proceso de enseñanza de las técnicas individuales del Voleibol en modalidad online, provocándose dificultades en el aprendizaje de los estudiantes evidenciadas en inconsistencias en la ejecución de las técnicas individuales y poca fluidez en los juegos. Objetivo. Constatar la validez de las actividades lúdicas en el proceso de enseñanza-aprendizaje de las técnicas individuales del Voleibol en modalidad online. Metodología. La investigación siguió un enfoque mixto, de tipo cuasiexperimental con el empleo de métodos teóricos y empíricos que permitieron dar solución al problema objeto de estudio mediante el desarrollo de cinco fases (diagnóstico, revisión documental, elaboración, aplicación y validación). Resultados. 1. Se logra sistematizar desde la teoría científica la importancia de las actividades lúdicas en los procesos de enseñanza-aprendizaje de la Educación Física, evidenciándose en la práctica su utilidad en el aprendizaje de las técnicas individuales del Voleibol en modalidad online. 2. Quedó constatada la validez de las actividades lúdicas realizadas como una alternativa viable para perfeccionar el proceso de enseñanza-aprendizaje de las técnicas individuales del Voleibol en modalidad online 3. Se aporta un programa de juegos que dada su estructura es factible a ser aplicado y generalizado. Conclusiones. Se cumplió con los objetivos previstos, aportándose un programa de actividades lúdicas que resulta valido para perfeccionar el aprendizaje de las técnicas individuales del voleibol en la modalidad online.
Bioprospecção do extrato de bromelina acrescida de ACP® na qualidade do sêmen caprino
Authors: Nascimento Wcleudem Matias , Texeira Letícia Soares de Araújo , Macêdo Laércio Fontinele Bandeira de , Porfírio Kenney de Paiva , Braga Clarissa de Castro e , Costa Sara Camila da Silveira , Silva Louis Henrique Miyauchi , Silva Francisca Kelly dos Santos , Aquino Elaine Nascimento , Corrêa José Raimundo , Mineiro Ana Lys Bezerra Barradas , Cardoso Janaina de Fátima Saraiva , Salgueiro Cristiane Clemente de Mello , Nunes José Ferreira , Amaral Fabrício Pires de Moura do , Paula Ney Rômulo de Oliveira , Vieira Rômulo José 
Published: November 2021

Objetivou-se avaliar o efeito do extrato de bromelina sobre a qualidade espermática, pós-descongelação na espécie caprina. Para tanto, foram utilizados cinco caprinos da raça Anglo Nubiana, com idade reprodutiva, clinicamente saudáveis. Foram realizadas colheitas de sêmen. Após a análise da concentração, o volume total do pool foi dividido em cinco grupos. Um pertencente ao grupo controle, composto de (ACP-101/102®) e quatro grupos experimentais com ACP-101/102® enriquecidos com extrato de bromelina nas concentrações de 5%; 10%; 15% e 20%. As amostras foram criopreservadas com auxílio do aparelho Tk3000®. Após o período de sete dias as amostras foram descongeladas e submetidas a avaliações pelo sistema CASA. Termo resistência, sondas fluorescente, teste cometa e teste de análise ultraestrutural de espermatozoides por meio de microscopia eletrônica de transmissão (MET). Na avaliação da cinética espermática pós-descongelação foi possível observar que os parâmetros motilidade espermática total, o grupo bromelina a 5%, se destacou dentre os demais, já na velocidade curvilínea e velocidade média da trajetória o grupo controle apresentou os melhores resultados. Quanto à integridade do DNA espermático as concentrações de bromelina (5%; 10%; 15% e 20%) não apresentaram diferença significativa em relação ao grupo controle, demonstrando que essa substância não apresenta genotoxicidade às células espermáticas. Na análise ultraestrutural o grupo bromelina a 5% demonstrou os melhores resultados. Nesse sentido, o extrato de bromelina adicionada a meios diluentes, visando à criopreservação, caracteriza-se como uma substância promissora, sobretudo da manutenção da integridade do DNA espermático. Contudo, mais estudos são necessários para a sua padronização.
Análise da produção científica brasileira sobre etnobotânica: protocolo de scoping review
Authors: Silva Maria Andréa da , Almeida Fernando Henrique Oliveira de , Santos Davi Cravo Teles dos , Silva Wellington Barros da , Silva Francilene Amaral da 
Published: November 2021

Este artigo apresenta o protocolo de revisão de escopo acerca da produção científica brasileira sobre etnobotânica. E tem como objetivo documentar os processos envolvidos no planejamento e na condução metodológica deste estudo inédito, examinando a extensão, o alcance e a natureza das atividades de pesquisa em etnobotânica no Brasil, com vistas a identificar as possíveis lacunas de pesquisa na literatura existente. Esta revisão será conduzida seguindo as diretrizes do Joanna Briggs Institute (JBI) e elaborada de acordo com os itens do PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Para tal, serão selecionados e revisados artigos científicos publicados nos idiomas: inglês, português e espanhol nas seguintes bases de dados: Web of Science, PubMed /Medline, Lilacs/BVS, Scopus e Scielo. Este protocolo foi registrado no Open Science Framework (OSF), sob doi: 10.17605/OSF.IO/N4XD3. Espera-se com esse estudo, mapear, demonstrar o cenário e o panorama dos estudos etnobotânicos realizados no Brasil, o que poderá orientar a realização de futuras pesquisas nessa temática em nosso país.
Perfil de estilo de vida e prevalência de Síndrome de Burnout em estudantes da área da saúde de uma universidade particular em Santarém-PA durante a pandemia da Covid-19: um estudo transversal
Authors: Amaral Fernanda Naiane Leal , Melo Carla Santos de , Pinto Luciana Santos , Sousa Diego Sarmento de 
Published: November 2021

Objetivo: Verificar o perfil de estilo de vida e a prevalência de Síndrome de Burnout em estudantes da área da saúde de uma universidade, durante a pandemia da COVID-19. Metodologia: Trata-se de um estudo epidemiológico observacional, do tipo descritivo e transversal, com 272 universitários da área da saúde. Como instrumentos de coleta de dados, utilizamos o questionário de Perfil do Estilo de Vida Individual (PEVI), o Inventário de Burnout de Maslach e questionário sociodemográfico. Resultados e discussão: Notou-se uma maior proporção para a classificação “positiva” nos componentes atividade física, comportamentos preventivos, relacionamento social e controle do estresse, assim como a classificação “intermediária” para o componente nutrição. No resultado geral do perfil de estilo de vida individual, os estudantes foram classificados como “intermediários” (44,1%), seguida de “positivos” (41,5%) e “negativos” (14,3%). Nas dimensões de Burnout, prevaleceram os estudantes com nível baixo em “exaustão emocional” (51,8%), nível alto em “descrença” (55,9%) e nível baixo em “realização profissional” (100%). A relação entre a ocorrência de Burnout e o perfil de estilo de vida apontou a presença de Burnout (n=14), prevalente no perfil “intermediário” (42,9%). Considerações finais: O estudo revela a necessidade de um maior investimento na prevenção e sensibilização da comunidade acadêmica para a adoção de um estilo de vida saudável. Sugere-se a realização de estudos mais abrangentes a respeito do tema, que sirvam como evidências para elaboração de medidas intervencionistas, tanto no âmbito acadêmico quanto nas políticas públicas para a promoção da saúde dos universitários.
Evidências científicas da assistência de enfermagem ao recém-nascido pré-termo
Authors: Almeida Rafaela Zeferino , Lima Reilda de Sá , Guimarães Tatiana Maria Melo , Santos Thamires Barbosa dos 
Published: November 2021

Objetivou-se descrever as evidências científicas acerca da assistência de enfermagem voltada ao recém-nascido pré-termo. Realizou-se um estudo de revisão integrativa de literatura. Para a busca de dados foram utilizados fontes de coleta nas plataformas online de pesquisa, Biblioteca Virtual em Saúde (BVS) nas seguintes bases de dados: Medical Literature Analysis and Retrieval System Online (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Banco de Dados em Enfermagem (BDENF) no período de 2016 a 2021. Foram utilizados os descritores “Assistência de Enfermagem”; “Recém-nascido Pré-maturo”, “Enfermagem Neonatal”. Foram selecionados 1.075, logo após foram aplicação os critérios de inclusão e selecionados 159 artigos para leitura de títulos e resumos. Em seguida foram selecionados 12 artigos que atendiam os objetivos da pesquisa para compor o estudo. Os resultados do estudo evidenciaram que o ano de maior publicação foi 2019, prevalecendo a abordagem qualitativa com 75% dos estudos selecionados, e a partir dos artigos analisados emergiram duas categorias, para discussão da temática: Cuidados de Enfermagem na assistência ao recém-nascido pré-termo e Conhecimentos do Enfermeiro acerca dos cuidados com o recém-nascido pré-termo. Concluiu-se que a assistência de enfermagem ao recém-nascido pré-termo é imprescindível porque eles precisam de assistência especializada em razão das condições clínicas, necessitam de um ambiente apropriado, com recursos tecnológicos e humanos adequados, para garantir o tratamento e restabelecimento da sua saúde.
Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging
Authors: Wang Wenqi , He Xiaowen , Du Mingzhi , Xie Chen , Zhou Wen , Huang Wei , Fan Quli 
Published: November 2021

Second near-infrared window (NIR-II) fluorescence imaging has shown great potential in the field of bioimaging. However, the excitation wavelengths of most NIR-II fluorescence dyes are in the first near-infrared (NIR-I) region, which leads to limited imaging depth and resolution. To address such issue, NIR-II fluorescence dyes with 1,064 nm excitation have been developed and applied for in vivo imaging. Compared with NIR-I wavelength excited dyes, 1,064 nm excited dyes exhibit a higher tissue penetration depth and resolution. The improved performance makes these dyes have much broader imaging applications. In this mini review, we summarize recent advances in 1,064 nm excited NIR-II fluorescence fluorophores for bioimaging. Two kinds of organic fluorophores, small molecule dye and semiconducting polymer (SP), are reviewed. The general properties of these fluorophores are first introduced. Small molecule dyes with different chemical structures for variety of bioimaging applications are then discussed, followed by the introduction of SPs for NIR-II phototheranostics. Finally, the conclusion and future perspective of this field is given.
Rivaroxaban Suppresses Atherosclerosis by Inhibiting FXa-Induced Macrophage M1 Polarization-Mediated Phenotypic Conversion of Vascular Smooth Muscle Cells
Authors: Ma Yanpeng , Zhang Yong , Qiu Chuan , He Chunhui , He Ting , Shi Shuang , Liu Zhongwei 
Published: November 2021

Background: Factor Xa (FXa) is a mediator initiating and accelerating atherosclerosis (AS). Both macrophage and vascular smooth muscle cells (VSMCs) participate in AS progression. This study was aimed to investigate the mechanisms underlying the effects of the FXa inhibitor rivaroxaban on AS.Methods: Rivaroxaban was administered to AS mice. Primary macrophages were exposed to FXa, treated with rivaroxaban, and transfected with siRNA silencing protease-activated receptor 2 (PAR2), hypoxia-inducible factor 1α (HIF1α), delta-like receptor 4 (Dll4), and Akt. Interaction between macrophages and VSMCs was assessed by co-culturing systems. Atherosclerotic lesions were evaluated by oil red O stain. Fluorescent staining was used to determine the cell phenotypes. Secretions of inflammatory cytokines and collagen were assessed by ELISA and Sircol assays. Western blotting was used to evaluate the protein expression and phosphorylation levels.Results: Rivaroxaban reduced lesion area, accumulation of M1 macrophages, and contractile-synthetic phenotypic conversion of VSMCs in atherosclerotic plaques. FXa exposure induced polarization of macrophages toward M1 and Dll4 high expression, which were inhibited by PAR2, Akt1, and HIF1α silencing. Rivaroxaban treatment inhibited PAR2/Akt/HIF1α signaling activation and Dll4 expression in FXa-exposed macrophages. By cell-to-cell contact, M1 macrophages induced Notch signaling activation in VSMCs which committed contractile-synthetic conversion. Rivaroxaban treatment and Dll4 silencing incapacitated macrophage in inducing phenotypic conversion of VSMCs upon cell-to-cell contact.Conclusion: Rivaroxaban suppresses AS by inhibiting FXa-induced PAR2/Akt/HIF1α signaling activation-mediated macrophage M1 polarization and high Dll4 expression. These macrophages facilitated VSMCs to perform contractile-synthetic phenotypic conversion upon macrophage-VSMCs cell-to-cell contact.
Layer-Specific Global Longitudinal Strain Predicts Arrhythmic Risk in Arrhythmogenic Cardiomyopathy
Authors: Segura-Rodríguez Diego , Bermúdez-Jiménez Francisco José , González-Camacho Lorena , Moreno Escobar Eduardo , García-Orta Rocío , Alcalá-López Juan Emilio , Bautista Pavés Alicia , Oyonarte-Ramírez José Manuel , López-Fernández Silvia , Álvarez Miguel , Tercedor Luis , Jiménez-Jáimez Juan 
Published: November 2021

Background: Arrhythmogenic cardiomyopathy (AC) is a life-threatening disease which predispose to malignant arrhythmias and sudden cardiac death (SCD) in the early stages of the disease. Risk stratification relies on the electrical, genetic, and imaging data. Our study aimed to investigate how myocardial deformation parameters may identify the subjects at risk of known predictors of major ventricular arrhythmias.Methods: A cohort of 45 subjects with definite or borderline diagnosis of AC was characterized using the advanced transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) and divided into the groups according to the potential arrhythmic risk markers, such as non-sustained ventricular tachycardia (NSVT), late gadolinium enhancement (LGE), and genetic status. Layer-specific global longitudinal strain (GLS) by TTE 2D speckle tracking was compared in patients with and without these arrhythmic risk markers.Results: In this study, 23 (51.1%) patients were men with mean age of 43 ± 16 years. Next-generation sequencing identified a potential pathogenic mutation in 39 (86.7%) patients. Thirty-nine patients presented LGE (73.3%), mostly located at the subepicardial-to-mesocardial layers. A layer-specific-GLS analysis showed worse GLS values at the epicardial and mesocardial layers in the subjects with NSVT and LGE. The epicardial GLS values of −15.4 and −16.1% were the best cut-off values for identifying the individuals with NSVT and LGE, respectively, regardless of left ventricular ejection fraction (LVEF).Conclusions: The layer-specific GLS assessment identified the subjects with high-risk arrhythmic features in AC, such as NSVT and LGE. An epicardial GLS may emerge as a potential instrument for detecting the subjects at risk of SCD in AC.
A Comparative Study of the Optimal Sizing and Management of Off-Grid Solar/Wind/Diesel and Battery Energy Systems for Remote Areas
Authors: Thirunavukkarasu M. , Sawle Yashwant 
Published: November 2021

Electrification in rural areas is relatively costly compared to urban areas. Therefore, the aim of this research is to identify the best combination of hybrid renewable energy systems (HRESs) to satisfy the load demand in a sustainable and cost-efficient way. The techno-economic study of stand-alone hybrid photovoltaic–wind turbine–diesel–battery-converter energy systems based on the hybrid optimization model for electric renewable (HOMER) simulation has been analyzed for various locations in the Tamil Nadu state, India. Various combinations of the systems have been compared and analyzed based on the performance of their technical parameters, costs, the electrical power production of each source, and unmet load. The findings indicated that the off-grid solar–wind–diesel–battery configuration is the most economical for all the sites among other system configurations. Comparing with conventional diesel generators among all the locations, a combination of solar/wind/diesel/battery is the economically best design for Thoothukudi, with the least and most reliable solution in terms of net present cost and cost of energy. Also, the impact of intermittent variables becomes significant, so sensitivity analysis for the various parameters has been carried out. The study finds that the least cost of electricity and the net present cost of electricity for Thoothukudi are achieved at 0.266 $/kWh and 138,197 $, respectively. This is economical compared to a stand-alone diesel system where the obtained COE is $1.88 and the NPC is $977523. In the stand-alone diesel operating mode, 41854 kg of CO2is produced, which is higher than CO2emissions associated with any other renewable energy systems. According to the results, the Kanyakumari location outperforms in terms of producing environmental pollutants with emission of 1,020 kg/y CO2at their best. Moreover, the results of the proposed study imply that the proposed renewable energy system in remote sites could be a more economical measure.
Catalytic Oxidation of Methylene Blue by Attapulgite/TiO2
Authors: Shang Jianping , Jiang Yu , Qin Xiaoping , Zhao Bin , Li Xuefei 
Published: November 2021

Methylene blue (MB) is a common pollutant in wastewater of printing and dyeing industry. At present, ozone oxidation is commonly used in the treatment of printing and dyeing wastewater. Ozone is used for oxidation reaction directly and indirectly. However, the reaction rate is not fast enough. In this study, the attapulgite (ATP) was modified by tetrabutyl titanate-ethanol solution. The TiO2/ATP nanocomposite with high catalytic activity was prepared. The synthesized samples were subjected to characterized by X-ray diffraction (XRD) and Fourier Transform infrared spectroscopy (FTIR). The morphology and particle size of the particles were observed by scanning electron microscopy (SEM). The TiO2/ATP nanocomposite was calcined at 300°C for 2 h, and the degradation rate of 80 mg/L methylene blue was 99.8%. The experimental results show that the ozone, temperature and mass transfer factors are excluded, and the effects of temperature, MB concentration and pH on the degradation of methylene blue are investigated. The optimal reaction conditions are as follows: The ozone concentration is 0.067 g/min; the ozone flow rate is 0.15 NL/min; the stirrer rotation speed is 550 r/min; the catalyst is 0.1 g; the temperature is 50°C; Based on the results, the reaction mechanism was derived and the kinetic study of the experiment was carried out.
Isobaric Tags for Relative and Absolute Quantification-Based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep With Morphologically Different Tails
Authors: Zhu Caiye , Cheng Heping , Li Na , Liu Tiaoguo , Ma Youji 
Published: November 2021

Background: Chinese indigenous sheep can be classified into two types according to their tail morphology: fat-rumped and thin-tailed sheep, of which the typical breeds are Altay sheep and Tibetan sheep, respectively.Methods: To identify the differentially expressed proteins (DEPs) underlying the phenotypic differences between tail types, we used isobaric tags for relative and absolute quantification (iTRAQ) combined with multi-dimensional liquid chromatography tandem-mass spectrometry (LC-MS/MS) technology to detect candidate proteins. We then subjected these to a database search and identified the DEPs. Finally, bioinformatics technology was used to carry out Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.Results: A total of 3,248 proteins were identified, of which 44 were up-regulated and 40 were down-regulated DEPs. Analyzing their GO function terms and KEGG pathways revealed that the functions of these DEPs are mainly binding, catalytic activity, structural molecule activity, molecular function regulator, and transporter activity. Among the genes encoding the DEPs, APOA2, GALK1, ADIPOQ, and NDUFS4 are associated with fat formation and metabolism.Conclusion: The APOA2, GALK1, ADIPOQ, and NDUFS4 genes may be involved in the deposition of fat in the tail of sheep. This study provides a scientific basis for the breeding of thin-tailed sheep.
Development of a Novel Nomogram for Predicting Premature Rupture of Membrane in Pregnant Women With Vulvovaginal Candidiasis
Authors: Yang Lilin , Wang Haikuan , Li Yanfang , Zeng Cheng , Lin Xi , Gao Jie , Luo Songping 
Published: November 2021

Objective: The aim of this study was to develop a nomogram to predict the risk of premature rupture of membrane (PROM) in pregnant women with vulvovaginal candidiasis (VVC).Patients and methods: We developed a prediction model based on a training dataset of 417 gravidas with VVC, the data were collected from January 2013 to December 2020. The least absolute shrinkage and selection operator regression model was used to optimize feature selection for the model. Multivariable logistic regression analysis was applied to build a prediction model incorporating the feature selected in the least absolute shrinkage and selection operator regression model. Discrimination, calibration, and clinical usefulness of the prediction model were assessed using the C-index, calibration plot, and decision curve analysis. Internal validation was assessed using bootstrapping validation.Results: Predictors contained in the prediction nomogram included age, regular perinatal visits, history of VVC before pregnancy, symptoms with VVC, cured of VVC during pregnancy, and bacterial vaginitis. The model displayed discrimination with a C-index of 0.684 (95% confidence interval: 0.631–0.737). Decision curve analysis showed that the PROM nomogram was clinically useful when intervention was decided at a PROM possibility threshold of 13%.Conclusion: This novel PROM nomogram incorporating age, regular perinatal visits, history of VVC before pregnancy, symptoms with VVC, cured of VVC during pregnancy, and bacterial vaginitis could be conveniently used to facilitate PROM risk prediction in gravidas.