bluuebunny/crossref_metadata_2025_split huggingface dataset:
Een schrijver verdwaald in het massamedialand
Authors: Czarnecka Bożena 
Published: December 2021

The mass media are a prominent actor in the current debate on literature. In many ways, they contribute to defining its terms and settings, including what is said, whose voice is deemed valid/legitimate, and how it is all done/expressed. The mass media no longer merely mediate; rather, they produce views on and assessments of writers and their work. In his book De literatuur draait door. De schrijver in het mediatijdperk (2019), Sander Bax discusses selected cases of the media presence of well-known Dutch authors and their books to offer an insightful and accurate exploration of the ways in which the mass media influence the debate on literature and literature itself.
Relationship Between Plasma Cell-Free DNA Changes and Lysyl Oxidase During the Treatment and Prognosis of Canine Transmissible Venereal Tumor
Authors: MohammadZahri Mona , Cheraghi Hadi , Shirani Dariush , Hatamkhani Ali 
Published: December 2021

Abstract
BackgroundTransmissible Venereal Tumor (TVT) is a wide tumor of canine, there are no effective markers to monitor the therapeutic response in real-time. Circulating biomarkers may be valuable for the early diagnosis and prognosis of cancers, so in this study, we aimed to investigate the significance of the cell-free DNA (cfDNA) and cfDNA integrity index to monitor the response of TVT to vincristine and compare them with lysyl oxidase activity. Plasma and sera were collected before drug administration within four weeks from fifteen male dogs. The analytical method was mainly based on quantitative polymerase chain reaction for short and long cfDNA, and lysyl oxidase activity was measured in serum.ResultsThe results of cfDNA integrity index showed significant (p<0.05) difference in a baseline to 2nd and 3rd week (with cut-off value 1.118 and 93.33% specificity). We found that the cfDNA integrity index was increased during weeks due to the reduction of shorts cfDNA in the 1st week after treatment. lysyl Oxidase activity was increased during the 4th week (p<0.001) but there were no significant differences in the other weeks compared to baseline. ROC analysis of lysyl Oxidase revealed high sensitivity (100%) and specificity (93%) 2nd, 3rd weeks on comparison between Baseline. Multivariate analysis between cfDNA integrity index and lysyl Oxidase showed significant correlation (p<0.05) only baseline results. ConclusionsTaken together, we propose short cfDNA, cfDNA integrity index, and lysyl Oxidase activity as a diagnostic biomarker and a putative prognostic candidate in TVT patients. These biomarkers could be used simultaneously for quickly diagnose TVT in combination with cytology.
Factors Associated With Feeding And Caregiving Practices For Children Under Five In Lowland Nepal: A Community-Based Cross-Sectional Survey
Authors: Dulal Sophiya , Prost Audrey , Karki Surendra , Merom Dafna , Shrestha Bhim Prasad , Bhandari Bishnu , Manandhar Dharma Sharan , Osrin David , Costello Anthony , Saville Naomi M. 
Published: December 2021

Abstract
Background: While nurturing care, including adequate nutrition and responsive caregiving and early learning, is critical to early childhood development, national surveys in Nepal highlight inequalities in feeding and parental caregiving practices. This study aimed to document and analyse infant and young child feeding (IYCF) and cognitive and socio-emotional caregiving practices among caregivers of children under age five in Dhanusha district, Nepal. Methods: We used a subset of data from the MIRA Dhanusha cluster randomised controlled trial, including mother-child dyads (N=1360) when children were aged 0-12 months and a follow-up survey of the same mother-child dyads (N=1352) when children were 7-59 months. We used World Health Organization IYCF indicators and questions from the Multiple Indicator Cluster Survey-4 tool to obtain information on IYCF and cognitive and socio-emotional caregiving practices, respectively. We collected data on breastfeeding practices in a postpartum 6-week questionnaire and on complementary feeding and caregiving practices in the follow-up survey. Using multivariable logistic regression models, potential explanatory household, parental and child-level variables were tested to determine their independent associations with IYCF and caregiving indicators. Results: The prevalence of feeding indicators varied. Ever breastfed (99%), exclusive breastfeeding in past 24-hours at 0-12 months (89%), and vegetable or fruit consumption (84%) were common, and minimum dietary diversity reached 63%. Problem areas were early initiation of breastfeeding (16%), feeding of colostrum (67%), no pre-lacteal feeding (53%), timely introduction of complementary feeding (56%), and animal-source food consumption (29%). Amongst caregiving indicators, access to books (7%), early stimulation and responsive caregiving (11%), and access to early childhood education (27%) were of particular concern, while 64% had access to toys and 71% received adequate care. Only 38% of children were developmentally on track. Younger children from poor households with young mothers who had not received antenatal visits and delivered at home were at risk of poor IYCF and caregiving practices. Conclusions: Poor IYCF and cognitive and socio-emotional caregiving practices are widely prevalent in lowland Nepal, which highlights the importance of improved integrated nutrition and caregiving interventions in resource-constrained settings.
tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector
Authors: Semenova Ekaterina , Jain Ishita , Kolesnik Matvey , Minakhin Leonid , Morozova Natalia , Shiriaeva Anna , Kirillov Alexandr , Medvedeva Sofya , Kuznedelov Konstantin , Borukhov Sergei , Makarova Kira , Koonin Eugene V. , Severinov Konstantin 
Published: December 2021

Abstract
Type VI CRISPR-Cas systems are the only CRISPR variety that cleaves exclusively RNA1,2. In addition to the CRISPR RNA (crRNA)-guided, sequence-specific binding and cleavage of target RNAs, such as phage transcripts, the type VI effector, Cas13, causes collateral RNA cleavage, which induces bacterial cell dormancy, thus protecting the host population from phage spread3,4. We show here that the principal form of collateral RNA degradation elicited by Cas13a protein from Leptotrichia shahii upon target RNA recognition is the cleavage of anticodons of multiple tRNA species, primarily those with anticodons containing uridines. This tRNA cleavage is necessary and sufficient for bacterial dormancy induction by Cas13a. In addition, Cas13a activates the RNases of bacterial toxin-antitoxin modules, thus indirectly causing mRNA and rRNA cleavage, which could provide a back-up defense mechanism. The identified mode of action of Cas13a resembles that of bacterial anticodon nucleases involved in antiphage defense5, which is compatible with the hypothesis that type VI effectors evolved from an abortive infection module6,7 encompassing an anticodon nuclease.
Flooding affects food web structure and basal sources supporting fish guilds in a subtropical wetland and shallow lake
Authors: Bastos Rodrigo Ferreira , Garcia Alexandre Miranda , Winemiller Kirk O. , Fontoura Nelson Ferreira 
Published: December 2021

Abstract
Aquatic ecosystems exchange nutrients and organic matter with surrounding terrestrial ecosystems, and floods import allochthonous material from riparian areas into fluvial systems. We surveyed food web components of a wetland and shallow lake in a subtropical coastal region of Brazil to examine how community trophic structure and the entrance of allochthonous material into the food web were affected by floods. Stable isotope analysis was performed for samples of terrestrial and aquatic basal production sources and aquatic animals to trace the origin of organic matter assimilated by aquatic animals and estimate vertical trophic positions and food chain length. Lake and wetland trophic structures were compared for cool/wet and warm/dry seasons. Food web structure was hypothesized to differ based on hydrology, with the more stable lake having greater food web complexity, and seasonal flooding resulting in greater allochthonous inputs to the aquatic food web. We compared spatial and temporal variation in assemblage trophic structure using an adapted isotopic ellipse approach that plots assemblage elements according to δ13C on the x-axis and estimated TP on the y-axis. Lake trophic structure was more complex with longer food chains compared to that of the wetland. A greater contribution from terrestrial resources to animal biomass was observed in the wetland during the cool/wet period, and food chains in both habitats tended to be longer during the cool/wet period. Findings supported the hypothesis of greater assimilation of allochthonous sources during floods and greater trophic complexity in the more hydrologically stable system.
Chk1 Inhibitor Induced DNA Damage Increases BFL1 and Decreases BIM but Does Not Protect Human Cancer Cell Lines From Chk1 Inhibitor-induced Apoptosis
Authors: Massey Andrew J. 
Published: December 2021

Abstract
V158411 is a potent, selective Chk1 inhibitor currently in pre-clinical development. We utilised RNAseq to evaluate the gene responses to V158411 treatment. BCL2A1 was highly upregulated in U2OS cells in response to V158411 treatment with BCL2A1 mRNA increased >400-fold in U2OS but not HT29 cells. Inhibitors of Chk1, Wee1 and topoisomerases but not other DNA damaging agents or inhibitors of ATR, ATM or DNA-PKcs increased BFL1 and decreased BIM protein. Increased BFL1 appeared limited to a subset of approximately 35% of U2OS cells. Out of 24 cell lines studied, U2OS cells were unique in being the only cell line with low basal BFL1 levels to be increased in response to DNA damage. Induction of BFL1 in U2OS cells appeared dependent on PI3K/AKT/mTOR/MEK pathway signalling but independent of NF-κB transcription factors. Inhibitors of MEK, mTOR and PI3K effectively blocked the increase in BFL1 following V15841 treatment. Increased BFL1 expression did not block apoptosis in U2OS cells in response to V158411 treatment and cells with high basal expression of BFL1 readily underwent caspase-dependent apoptosis following Chk1 inhibitor therapy. BFL1 induction in response to Chk1 inhibition appeared to be a rare event that was dependent on MEK/PI3K/AKT/mTOR signalling.
A Lightweight Keypoint Matching Framework for Morphometric Landmark Detection
Authors: Nguyen Hoang Ha , Ho Bich Hai , Lai Hien Phuong , Tran Hoang Tung , Le Huu Ton , Banuls Anne - Laure , Prudhomme Jorian 
Published: December 2021

Abstract
Geometric morphometrics has become an important approach in insect morphology studies because it capitalizes on advanced quantitative methods to analyze shape. Shape could be digitized as a set of landmarks from specimen images. However, the existing tools mostly require manual landmark digitization, and previous works on automatic landmark detection methods do not focus on implementation for end-users. Motivated by that, we propose a novel approach for automatic landmark detection, based on visual features of landmarks and keypoint matching techniques. While still archiving comparable accuracy to that of the state-of-the-art method, our framework requires less initial annotated data to build prediction model and runs faster. It is lightweight also in terms of implementation, in which a four-step workflow is provided with user-friendly graphical interfaces to produce correct landmark coordinates both by model prediction and manual correction. The utility iMorph is freely available at https://github.com/ha-usth/WingLanmarkPredictor, currently supporting Windows, MacOS, and Linux.
Ecological Efficiency Evaluation and Spatiotemporal Characteristics Analysis of the Coupling Coordination of the Logistics Industry and Manufacturing Industry
Authors: Su Juan , Shen Tong , jin shuxin 
Published: December 2021

Abstract
The coupling coordination of the logistics industry and manufacturing industry conducive to the sustainable development of logistics and manufacturing and the stability of sustainable supply chain. The logistics and manufacturing industries are not only the basic industries that support social development, but also the industries with high carbon emissions. Firstly, this paper classifies the carbon emissions from the logistics industry and manufacturing industry as undesirable outputs, evaluates the ecological efficiency of the logistics industry (LEE) and manufacturing industry (MEE) in the Yangtze River Delta from 2006 to 2019 by using the unexpected slacks-based measure (SBM) model. Secondly, the coupling coordination method is used to analyze the coupling coordination scheduling of industrial ecological efficiency. Thirdly, the paper analyzes the spatial differences of the coupling coordination ecological efficiency between logistics industry and manufacturing industry (MLCC) by using the exploratory spatial data analysis method. Finally, the spatial econometric model is used to analyze the driving factors of the MLCC. The results show: The ecological efficiency of the manufacturing industry has steadily improved. The ecological efficiency of the logistics industry presents the rising trend in fluctuation. The level of the coupling coordination development between the logistics and manufacturing industries is high. The results of the spatial heterogeneity analysis show that the spatial differentiation of high-high agglomeration and low-low agglomeration is obvious. The spatial agglomeration characteristics are relatively stable, and the spatial diffusion effect is strong; In space, the MLCC shows a trend of developing from multiple agglomeration areas to one agglomeration area. The results of driving factor analysis show that foreign direct investment(FDI), government intervention(GI) and human capital(HP) have positive effects on the MLCC, while industrial structure(IS), environmental regulation(ER) and energy intensity(EI) have negative effects on the MLCC.
The Relationship Between Delirium and Statin Use According To Disease Severity in Patients in the Intensive Care Unit
Authors: An Jun Yong , Park Jin Young , Cho Jaehwa , Kim Hesun Erin , Park Jaesub , Oh Jooyoung 
Published: December 2021

Abstract
Background

There have been few earlier studies on the efficacy of statins in the prevention of delirium. However, the results were controversial. The aim of this study was to investigate the association between the use of statins and the occurrence of delirium in a large cohort of patients in the intensive care unit (ICU), considering disease severity and statin properties, which were not sufficiently considered in the previous works.
Methods

We obtained clinical and demographical information from 3604 patients admitted to the ICU of Gangnam Severance Hospital from January 2013 to April 2020. This included information on daily statin use and delirium state, as assessed by the Confusion Assessment Method for ICU. We used inverse probability of treatment weighting and categorized the ICU patients into four groups based on the Acute Physiology and Chronic Health Evaluation II score (group 1: 0-10 - mild; group 2: 11-20 – mild to moderate; group 3: 21-30 – moderate to severe; group 4: > 30 - severe). We analyzed the association between the use of statin and the occurrence of delirium in each group, while taking into account the properties of statins.
Results

Comparisons between statin and non-statin patient groups revealed that only in group 2, patients who were administered statin showed significantly higher occurrence of delirium (p=0.004, odds ratio [OR]=1.58) compared to the patients who did not receive statin. Regardless of whether statins were lipophilic (p=0.036, OR=1.47) or hydrophilic (p=0.032, OR=1.84), the occurrence of delirium was higher only in patients from group 2. Although both lipophilic and hydrophilic statins in group 2 were associated with delirium, neither showed a greater association than the other.
Conclusions

The use of statins may be associated with the increases in the risk of delirium occurrence in patients with mild to moderate disease severity, irrespective of statin properties, as revealed by results from a large cohort study.
Magnetospheric Convection: From Mesoscale Flows To Microscale Instabilities
Authors: Ukhorskiy Aleksandr Y. , Sorathia Kareem A. , Merkin Viacheslav G. , Crabtree Chris , Fletcher Alex C. , Malaspina David M. , Schwartz Steven J. 
Published: December 2021

Abstract
Plasma convection in the Earth’s magnetosphere from the distant magnetotail to the inner magnetosphere occurs largely in the form of mesoscale flows, i.e., discrete enhancements in the plasma flow with sharp dipolarizations of magnetic field. Recent spacecraft observations suggest that the dipolarization flows are associated with a wide range of kinetic processes such as kinetic Alfvén waves, whistler chorus waves, and nonlinear time-domain structures. In this paper we explore how mesoscale dipolarization flows produce suprathermal electron instabilities, thus providing free energy for the generation of the observed kinetic waves and structures. We employ three-dimensional test-particle simulations of electron dynamics one-way-coupled to a global magnetospheric model. The simulations show a rapid growth of interchanging regions of parallel and perpendicular electron temperature anisotropies distributed along the magnetic terrain formed around the dipolarization flows. Unencumbered in test-particle simulations, a rapid growth of velocity-space anisotropies in the collisionless magnetotail plasma is expected to be curbed by the generation of plasma waves. The results are compared with in situ observations of an isolated dipolarization flow at one of the spacecraft of the Magnetospheric Multiscale Mission, that show strong VLF wave activity alternating between broad-band wave activity and whistler waves. With estimated spatial extent being similar to the characteristic size of temperature anisotropy patches in our test-particle simulations, the observed bursts of VLF wave activity are likely to be produced by the parallel and perpendicular electron energy anisotropies driven by the dipolarization flow, as suggested by our results.
Development and Validation of a Novel M6A-related LncRNA Prognostic Signature Associated with Immune Microenvironment for Ovarian Serous Cystadenocarcinoma
Authors: Geng Rui , Chen Tian , Zhong Zihang , Ni Senmiao , Bai Jianling , Liu Jinhui 
Published: December 2021

Abstract
Background: OV is the most lethal gynecological malignancy. M6A and lncRNAs have great influence on OV development and patients' immunotherapy response. Here, we decided to establish a reliable signature in the light of mRLs. Method: The lncRNAs associated with m6A in OV were analyzed and obtained by co-expression analysis in the light of TCGA-OV database. Univariate, LASSO and multivariate Cox regression analyses were employed to establish the model in the light of the mRLs. K-M analysis, PCA, GSEA, and nomogram based on the TCGA-OV and GEO database were conducted to prove the predictive value and independence of the model. The underlying relationship between the model and TME and cancer stemness properties were further investigated through immune features comparison, consensus clustering analysis, and Pan-cancer analysis.Results: A prognostic signature comprising four mRLs: WAC-AS1, LINC00997, DNM3OS, and FOXN3-AS1, was constructed and verified for OV according to TCGA and GEO database. The expressions of the four mRLs were confirmed by qRT-PCR in clinical samples. Applying this signature, people can identify patients more effectively. All the sample were assigned into two clusters, and the clusters had different overall survival, clinical features, and tumor microenvironment. Finally, Pan-cancer analysis further demonstrated the four mRLs significantly related to immune infiltration, TME and cancer stemness properties in various cancer types. Conclusion: This study provided an accurate prognostic signature for patients with OV and elucidated the potential mechanism of the mRLs in immune modulation and treatment response, giving new insights into identifying new therapeutic targets.
METHANE LIQUEFACTION: Selective Conversion of Methane to Cyclohexane via Efficient Surface-Hydrogen-Transfer Catalyzed by GaN-Supported Platinum Clusters
Authors: Tan Li-Da , Su Hui , Han Jingtan , Li Mingxin , Li Chao-Jun 
Published: December 2021

Abstract

Non-oxidative liquefaction of methane at room temperature and ambient pressure has long been a scientific “holy grail” of chemical research. In this report, we exploit an unprecedented catalytic transformation of methane exclusively to cyclohexane through effective surface-hydrogen-transfer (SHT) at the heterojunctions boundary consisting of electron-rich platinum cluster (Pt) loaded on methane-activating gallium nitride (GaN) host. The experimental analysis demonstrates that interface-induced overall reaction starts with methane aromatization to benzene initiated by the Ga-N pairs, followed by hydrogenation of benzene to cyclohexane via hydrogen transfer. The in-situ activated hydrogen at electron-rich metal Pt cluster plays a key role for the hydrogenation and enables an outstanding selectivity (as high as 89 %) towards cyclohexane, which is well-delivered even after 5 recycling runs.
Young Stroke Secondary To Fibromuscular Dysplasia Causing Carotid Artery Dissection
Authors: Ranasinghe Rumesh , Azher Shifa , Ralapanawa Udaya , Karunathilake Parackrama 
Published: December 2021

Abstract
Background: Fibromuscular dysplasia (FMD) is a rare, medium-sized arteriopathy affecting less than 7% of the population. It affects predominantly young women of childbearing age. Stroke caused by fibromuscular dysplasia of the carotid artery is uncommon and reported to range between 0.6% by angiography and 1.1% by autopsy. Case Presentation: A 35-year-old mother of two children, previously well, was admitted to our hospital with right-sided spastic hemiparesis with upper motor neuron type facial nerve palsy. Non-contrast CT (NCCT) brain on admission revealed left-sided middle cerebral arterial territory infarction with possible hemorrhagic transformation with midline shift. She had progressive neurological features where NCCT brain in 24 hours showed an increase in the size of the hemorrhage. Magnetic resonance imaging (MRI) of the brain, including angiogram of neck vessels, revealed acute dissection of the left internal carotid artery with acute thrombosis, left frontoparietal hemorrhagic infarction, and the constellation of MRI showed features suggestive of left cervico-cranial fibromuscular dysplasia complicated by acute internal carotid artery dissection. She was started on low-dose aspirin, and 40 mg of atorvastatin and anticoagulants were not started because of the bleeding risk as she had a hemorrhagic transformation infarction. She was discharged and referred for inward physiotherapy and planned to repeat the MRI brain with the neck vessel angiogram in three weeks and arranged digital subtraction angiography in three months. Unfortunately, she was lost for follow-up.Conclusion: Detailed evaluation of the young patients with ischaemic stroke is helpful to diagnose rare diseases such as FMD involving carotid arteries leading to a better treatment choice between anticoagulation vs. antiplatelet therapy.