bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preface: 3rd International Conference on Innovations in Economic Management and Social Science (IEMSS 2021)
Authors: Qian Shenliang , Springhall Joyce 
Published: November 2021

The organizing committee of IEMSS 2021 is proud to present the proceedings of the 2021 3rd International Conference on Innovations in Economic Management and Social Science, held in Hohhot, China during November 27-28, 2021.

IEMSS 2021 aims to bring together researchers, scientists, engineers, and scholar students to exchange and share their experience, new ideas, and research results about all aspects of innovations in economic management and social science, and discuss the practical challenges encountered and the solutions adopted.

IEMSS 2021 received more than 50 manuscripts, and less than 40 submissions have been accepted by our reviewers. By submitting a paper to IEMSS 2021, the authors agreed to the review process and understood that papers would undergo a peer-review process. Manuscripts were reviewed by appropriately qualified experts in the field selected by the conference committee, who took detailed comments and-if the submission was accepted-the authors would submit a revised version that took into account this feedback.

Hopefully, all participants and other interested readers will benefit scientifically from the proceedings and also find it stimulating in the process.

With warmest regards,

IEMSS Conference Organizing Committees
Hohhot, China
BÖLGESEL GÜÇ OLMA BAĞLAMINDA SİYASAL PAZARLAMA AÇISINDAN KAMU DİPLOMASİSİ: KURTLAR VADİSİ DİZİSİ SÖYLEM ANALİZİ
Authors: KILIÇASLAN Emine 
Published: November 2021

Bölgesel güç olma bağlamında siyasal pazarlama açısından Türk dizilerinin gerek Ortadoğu gerekse Balkanlar ve Türk Cumhuriyetlerinde gösterime girmesi Türk kamu diplomasisi açısından oldukça önemli bir güçtür. Yumuşak güç olarak tanımlanan kamu diplomasisinin kültürel boyutu ile alakalı olan bu olgu, Türk sinema ve dizi sektörünün gelişmesinde de önemli rol oynamaktadır. Türkiye Cumhuriyeti’nin bölgesel güç olması bağlamında önem taşıyan bu diziler ekonomik, siyasal ve kültürel güç ilişkileri bağlamında tanıtım amaçlı da hizmet vermektedir.
Bu bağlamda bu araştırmanın amacı Kurtlar Vadisi ve Kurtlar Vadisi Pusu dizi serisinin işlediği siyasal pazarlama kavramlarının bölgesel güç olma bağlamında Türk kamu diplomasisi açısından önemini göstermektir. Bu nedenle araştırmanın inceleme materyali Kurtlar Vadisi ve Kurtlar Vadisi Pusu dizi serisidir. Kurtlar Vadisi ve Kurtlar Vadisi Pusu dizi serisinin gösterimi ile ilgili çıkan haberler pozitif, negatif ve nötr olarak, söylem analizi yöntemi ile analiz edilmiştir.
Evaluating whole-genome sequencing quality metrics for enteric pathogen outbreaks
Authors: Wagner Darlene D. , Carleton Heather A. , Trees Eija , Katz Lee S. 
Published: November 2021

Background
Whole genome sequencing (WGS) has gained increasing importance in responses to enteric bacterial outbreaks. Common analysis procedures for WGS, single nucleotide polymorphisms (SNPs) and genome assembly, are highly dependent upon WGS data quality.

Methods
Raw, unprocessed WGS reads from Escherichia coli, Salmonella enterica, and Shigella sonnei outbreak clusters were characterized for four quality metrics: PHRED score, read length, library insert size, and ambiguous nucleotide composition. PHRED scores were strongly correlated with improved SNPs analysis results in E. coli and S. enterica clusters.

Results
Assembly quality showed only moderate correlations with PHRED scores and library insert size, and then only for Salmonella. To improve SNP analyses and assemblies, we compared seven read-healing pipelines to improve these four quality metrics and to see how well they improved SNP analysis and genome assembly. The most effective read healing pipelines for SNPs analysis incorporated quality-based trimming, fixed-width trimming, or both. The Lyve-SET SNPs pipeline showed a more marked improvement than the CFSAN SNP Pipeline, but the latter performed better on raw, unhealed reads. For genome assembly, SPAdes enabled significant improvements in healed E. coli reads only, while Skesa yielded no significant improvements on healed reads.

Conclusions
PHRED scores will continue to be a crucial quality metric albeit not of equal impact across all types of analyses for all enteric bacteria. While trimming-based read healing performed well for SNPs analyses, different read healing approaches are likely needed for genome assembly or other, emerging WGS analysis methodologies.
COVID‐19 exposure, pandemic‐related appraisals, coping strategies, and psychological symptoms among the frontline medical staff and gender differences in coping processes
Authors: Chen Chen , Guan Ziqi , Sun Liqun , Zhou Ting , Guan Ruiyuan 
Published: November 2021

AbstractThis study sought to explore the effects of COVID‐19 exposure, pandemic‐related appraisals and coping strategies on psychological symptoms among the front‐line healthcare workers based on the transactional theory of stress and coping. A cross‐sectional study was conducted in a Wuhan hospital designated for inpatients with COVID‐19, assessing COVID‐19 exposure (whether or not exposed to confirmed patients at workplace), psychological symptoms, appraisals, and coping strategies in 311 participants. Results revealed that the pandemic markedly affected healthcare workers' mental well‐being through appraisal and coping, with 38.9% reporting high levels of psychological symptoms. Primary appraisal related closely with COVID‐19 exposure, especially in female, while secondary appraisal was associated with problem‐focused coping. Both problem‐focused and emotion‐focused coping had a protective effect against psychological symptoms, but also showed gender differences in its relations with other variables. These findings could potentially benefit to enrich relevant theories, and to develop psychological programs for future epidemics.
Bottom‐Up‐Etching‐Mediated Synthesis of Large‐Scale Pure Monolayer Graphene on Cyclic‐Polishing‐Annealed Cu(111)
Authors: Yao Wenqian , Zhang Jianing , Ji Jie , Yang He , Zhou Binbin , Chen Xin , Bøggild Peter , Jepsen Peter U. , Tang Jilin , Wang Fuyi , Zhang Li , Liu Jiahui , Wu Bin , Dong Jichen , Liu Yunqi 
Published: November 2021

AbstractSynthesis of large‐scale single‐crystalline graphene monolayers without multilayers involves the fabrication of proper single‐crystalline substrates and the ubiquitous formation of multilayered graphene islands during chemical vapor deposition. Here, a method of cyclic electrochemical polishing combined with thermal annealing, which allows the conversion of commercial polycrystalline Cu foils to single‐crystal Cu(111) with an almost 100% yield, is presented. A global “bottom‐up‐etching” method that is capable of fabricating large‐area pure single‐crystalline graphene monolayers without multilayers through selectively etching bottom multilayered graphene underneath large area as‐grown graphene monolayer on Cu(111) surface is demonstrated. Terahertz time‐domain spectroscopy (THz‐TDS) measurement of the pure monolayer graphene film shows a high average sheet conductivity of 2.8 mS and mean carrier mobility of 6903 cm2 V−1 s−1 over a large area. Density functional theory (DFT) calculations show that the selective etching is induced by the much easier diffusion of hydrogen atoms than hydrocarbon radicals across the edges of the top graphene layer, and the simulated selective etching processes based on phase field modeling are well consistent with experimental observations. This work provides new ways toward the production of single‐crystal Cu(111) and the synthesis of pure monolayer graphene with high electronic quality.
Binding of Natural Peptide Ligands to the Neuropeptide Y5 Receptor
Authors: Rudolf Sarina , Kaempf Kerstin , Vu Oanh , Meiler Jens , Beck‐Sickinger Annette G. , Coin Irene 
Published: November 2021

AbstractThe binding mode of natural peptide ligands to the Y5 G protein‐coupled receptor (Y5R), an attractive therapeutic target for the treatment of obesity, is largely unknown. Here, we apply complementary biochemical and computational approaches, including scanning of the receptor surface with a genetically encoded crosslinker, Ala‐scanning of the ligand and double‐cycle mutagenesis, to map interactions in the ligand‐receptor interface and build a structural model of the NPY‐Y5R complex guided by the experimental data. In the model, the carboxyl (C)‐terminus of bound NPY is placed close to the extracellular loop (ECL) 3, whereas the characteristic α‐helical segment of the ligand drapes over ECL1 and is tethered towards ECL2 by a hydrophobic cluster. We further show that the other two natural ligands of Y5R, peptide YY (PYY) and pancreatic polypeptide (PP) dock to the receptor in a similar pose.
Nanoconfinement Engineering over Hollow Multi‐Shell Structured Copper towards Efficient Electrocatalytical C−C coupling
Authors: Liu Chunxiao , Zhang Menglu , Li Jiawei , Xue Weiqing , Zheng Tingting , Xia Chuan , Zeng Jie 
Published: November 2021

AbstractNanoconfinement provides a promising solution to promote electrocatalytic C−C coupling, by dramatically altering the diffusion kinetics to ensure a high local concentration of C1intermediates for carbon dimerization. Herein, under the guidance of finite‐element method simulations results, a series of Cu2O hollow multi‐shell structures (HoMSs) with tunable shell numbers were synthesized via Ostwald ripening. When applied in CO2electroreduction (CO2RR), the in situ formed Cu HoMSs showed a positive correlation between shell numbers and selectivity for C2+products, reaching a maximum C2+Faradaic efficiency of 77.0±0.3 % at a conversion rate of 513.7±0.7 mA cm−2in a neutral electrolyte. Mechanistic studies clarified the confinement effect of HoMSs that superposition of Cu shells leads to a higher coverage of localized CO adsorbate inside the cavity for enhanced dimerization. This work provides valuable insights for the delicate design of efficient C−C coupling catalysts.
Altering Chain Flexibility of Aliphatic Polyesters for Yellow‐Green Clusteroluminescence in 38 % Quantum Yield
Authors: Chu Bo , Zhang Haoke , Hu Lanfang , Liu Bin , Zhang Chengjian , Zhang Xinghong , Tang Ben Zhong 
Published: November 2021

AbstractPreparation of non‐conjugated polymers with long‐wavelength emission and high quantum yield (QY) is still a huge challenge. Herein, we report the first example of linear non‐conjugated polyester exhibiting yellow–green clusteroluminescence (CL) and a high QY of 38 %. We discovered that the polyester P3 with balanced flexibility and rigidity showed the longest CL wavelength and highest QY. Systematically photophysical characterization unravel the key role of ester cluster in the CL and the cluster formation via the aggregate of ester units was visualized. Moreover, P3 was demonstrated to be a highly selective, quick‐responsive (ca. 1.2 min) and sensitive detector (detection limit is 0.78 μM) for irons owing to the fast disassociation of clusters by irons. This work not only gains further mechanistic insight into CL but also provides a new strategy to design high‐efficiency and long‐wavelength CL, meanwhile, enlightens the glorious application prospect of luminescent polyester.
External reproductive structures of male Surfperches (Embiotocidae): Urogenital papilla
Authors: Bond Evelyn Ruelas , Forsgren Kristy L. 
Published: November 2021

AbstractFishes exhibit a dynamic array of reproductive diversity. Among the various forms of reproduction, internal fertilization has evolved at least 13 times and has been observed in 2–3% of teleost species, half of which are marine. Internal fertilization has led to the evolution of male intromittent organs to aid in sperm transfer during copulation. The intromittent organs of poeciliids have been widely investigated, but little research has focused on the intromittent organs of marine fishes. The surfperches are internally fertilizing, viviparous fishes with a ventrally located papilla. In this article, the external morphology of 19 Embiotocidae species was examined. Additionally, paraffin histology was used to investigate the walleye surfperch (Hyperprosopon argenteum), black perch (Embiotoca jacksoni), and dwarf perch (Micrometrus minimus) papilla to aid in the identification of tissue composition to determine its function. External morphology was documented via macro photography and males were dissected to observe the relationship between the testes, spermatic duct, and papilla. We provide histological evidence that the urogenital papilla is directly connected to the spermatic duct and testis and likely involved in spermatozeugmata transfer. Our research also determined that the papillae were composed of both urinary and reproductive tissues, thus we propose the papilla be referred to as a urogenital papilla. Our study contributes to an overall understanding of intromittent organs of marine fishes, particularly in the surfperches, which has not been previously documented.
Heterocycle‐modified 2′‐Deoxyguanosine Nucleolipid Analogs Stabilize Guanosine Gels and Self‐assemble to Form Green Fluorescent Gels
Authors: Walunj Manisha B. , Srivatsan Seergazhi G. 
Published: November 2021

AbstractNucleoside‐lipid conjugates are very useful supramolecular building blocks to construct self‐assembled architectures suited for biomedical and material applications. Such nucleoside derivatives can be further synthetically manipulated to endow additional functionalities that could augment the assembling process and impart interesting properties. Here, we report the design, synthesis and self‐assembling process of multifunctional supramolecular nucleolipid synthons containing an environment‐sensitive fluorescent guanine. The amphiphilic synthons are composed of an 8‐(2‐(benzofuran‐2‐yl)vinyl)‐guanine core and alkyl chains attached to 3′‐O and 5′‐O‐positions of 2′‐deoxyguanosine. The 2‐(benzofuran‐2‐yl)vinyl (BFV) moiety attached at the C8 position of the nucleobase adopted a syn conformation about the glycosidic bond, which facilitated the self‐assembly process through the formation of a G‐tetrad as the basic unit. While 3′,5′‐diacylated BFV‐modified dG analog stabilized the guanosine hydrogel by hampering the crystallization process and imparted fluorescence, BFV‐modified dGs containing longer alkyl chains formed a green fluorescent organogel, which transformed into a yellow fluorescent gel in the presence of a complementary non‐fluorescent cytidine nucleolipid. The ability of the dG analog containing short alkyl chains to modulate the mechanical property of a gel, and interesting fluorescence properties and self‐assembling behavior exhibited by the dG analogs containing long alkyl chains in response to heat and complementary base underscore the potential use of these new supramolecular synthons in material applications.
A Comparative Study on Essential Oil Profile and Antioxidant Activity in Different Parts of Three Ferulago Species
Authors: Narimani Rasoul , Moghaddam Mohammad , Mahmoodi Sourestani Mohammad , Samiei Leila 
Published: November 2021

AbstractIn the present study, the phytochemical features of the essential oils from leaves, flowers, and fruits in three Ferulago species including F. angulata, F. carduchorum, and F. contracta was investigated. The essential oils were extracted using the hydrodistillation method and analyzed by GC‐FID and GC/MS. The essential oil content varied between 0.46 to 2.65 % (v/w) among the various parts of the studied species. Monoterpene hydrocarbons (leaves: 34.80–78.76 %, flowers: 88.67–94.26 %, fruits: 89.54–94.21 %) constituted the main fraction of three Ferulago species. The major compounds of the essential oil among the species were α‐pinene (15.01–22.16 %), β‐phellandrene (2.48–14.73 %), α‐phellandrene (0.52–13.8 %), and germacrene B (0.11–13.28 %) in leaves; (Z)‐β‐ocimene (38.46–47.21 %), α‐pinene (10.25–18.32 %), and α‐phellandrene (5.07–9.44 %) in flowers; (Z)‐β‐ocimene (10.21–41.19 %), α‐phellandrene (7.51–31.89 %), α‐pinene (8.96–17.71 %), β‐phellandrene (7.24–17.44 %), terpinolene (2.90–7.77 %), and δ‐3‐carene (1.57–7.66 %) in fruits. The classical antioxidant activity of the essential oils was assessed using the DPPH method. The fruit essential oils of the studied species induced a significant level of antioxidant activity compared to ascorbic acid (EC50=50.24 μg/mL). The highest level of antioxidant activity was found in F. carduchorum (EC50=68.75 μg/mL) fruits essential oil. Ferulago species, therefore, have the potential to be utilized as natural antioxidants in the pharmaceutical, food or cosmetic industries owing to their high level of antioxidant activity.
Structural Characterization of Polysaccharides Isolated from Panax notoginseng Medicinal Residue and Its Protective Effect on Myelosuppression Induced by Cyclophosphamide
Authors: Liu Yanhong , Li Shuang , Pu Mengdi , Qin Huayan , Wang Hong , Zhao Yunqi , Chen Tong 
Published: November 2021

AbstractThis study aims to establish the isolation and purification method of polysaccharides from medicinal residue of Panax notoginseng (PPN). The structure and protective effect of PPN on myelosuppression mice were investigated. One neutral polysaccharide (NPPN) and five acidic polysaccharides (APPN I, APPN II‐A, APPN II‐B, APPN III‐A, and APPN III‐B) were obtained. The results confirmed that NPPN, APPN I and APPN II‐A are glycan with 1, 4 main chains. APPN III‐A is a glycan. APPN II‐B and APPN III‐B are homogalacturonan pectin with 1, 4 main chains. This study demonstrated that NPPN played a bone marrow protective role in myelosuppression mice induced by cyclophosphamide. NPPN could relieve cell cycle arrest, reduce the apoptosis rate of marrow cells, and improve granulocyte‐macrophage colony‐stimulating (GM‐CSF), thermoplastic polyolefin (TPO) and erythropoietin (EPO) serum level, which contributes to promoting the proliferation of hematopoietic cells.
Overexpression and Characterization of a Novel Plant Carotenoid Cleavage Dioxygenase 1 from Morus notabilis
Authors: Qi Zhipeng , Fan Xianyu , Zhu Chunyi , Chang Dongsheng , Pei Jianjun , Zhao Linguo 
Published: November 2021

AbstractSynthesis of β‐ionone in microbial cell factories is limited by the efficiency of carotenoid cleavage dioxygenases (CCDs). To obtain genes responsible for specific cleavage of carotenoids generating β‐ionone, a novel carotenoid cleavage dioxygenase 1 from Morus notabilis was cloned and overexpressed in Escherichia coli. The MnCCD1 protein was able to cleave a variety of carotenoids at the positions 9, 10 (9′, 10′) to produce β‐ionone, 3‐hydroxy‐4‐oxo‐β‐ionone, 3‐hydroxy‐β‐ionone, and 3‐hydroxy‐α‐ionone in vitro. MnCCD1 could also cleave lycopene and β‐carotene at the 9, 10 (9′, 10′) bind bond to produce pseudoionone and β‐ionone, respectively, in E. coli accumulating carotenoids. The enzyme activity of MnCCD1 was reached 2.98 U/mL at optimized conditions (temperature 28 °C, IPTG 0.1 mM, induction time 24 h). The biochemical characterization of MnCCD1 revealed the optimal activities were at pH 8.4 and 35 °C. The addition of 10 % ethanol could increase enzyme activity at above 15 %. However, an obvious decline was observed on enzyme activity as the concentration of Fe2+ increased (0–1 mM). The Vmax for β‐apo‐8′‐carotenal was 72.5 U/mg, while the Km was 0.83 mM. The results provide a foundation for developing the application of carotenoid cleavage dioxygenases as biocatalysis and synthetic biology platforms to produce volatile aroma components from carotenoids.
Massive pericardial effusion as the first manifestation of childhood non‐Hodgkin's lymphoma: A case report
Authors: Alizadeh Behzad , Shaye Zahra , Badiea Zahra , Dehghanian Paria 
Published: November 2021

AbstractAlthough one of the serious manifestations of advanced malignancies is pericardial involvement, pericardial involvement of lymphoma is extremely rare. We present a case of a 6‐year‐old girl arriving at the hospital with dyspnea and pleuritic chest pain, which is eventually diagnosed with massive pericardial effusion due to mediastinal non‐Hodgkin lymphoma.
Concomitant decalcification of the anterior mitral leaflet via the aortic annulus during aortic valve replacement for significant aortic and mitral stenoses
Authors: Furuta Akihisa , Mukai Shogo , Morimoto Hironobu , Kitaura Junya , Futagami Daisuke 
Published: November 2021

AbstractAn 82‐year‐old man undergoing regular hemodialysis with substantial aortic and mitral valve stenoses underwent aortic valve replacement with concomitant mitral decalcification via the aortic annulus. Postoperative transthoracic echocardiography showed reduced mitral stenosis. The patient was discharged on the 14th postoperative day uneventfully.
Rapidly destructive coxarthrosis accompanied by fluctuating C‐reactive protein level
Authors: Shimizu Hayato , Nishioka Hiroaki 
Published: November 2021

AbstractRapidly destructive coxarthrosis is a rare entity of unknown etiology that is characterized by rapid hip joint destruction. Blood tests are thought to be non‐specific. However, we herein show a patient with rapidly destructive coxarthrosis, which was accompanied by fluctuating C‐reactive protein level.
Mechanism‐Based Approach to Reagent Selection for Oxidative Carbon−Hydrogen Bond Cleavage Reactions
Authors: Miller Jenna L. , Zhou Lin , Liu Peng , Floreancig Paul E. 
Published: November 2021

AbstractNumerous hydride‐abstracting agents generate the same cationic intermediate, but substrate features such as intermediate cation stability, oxidation potential, and steric environment can influence reaction rates in an oxidant‐dependent manner. This manuscript provides experimental data to illustrate the role that structural features play in the kinetics of hydride abstraction reactions with commonly used quinone‐, oxoammonium ion‐, and carbocation‐ based oxidants. Computational studies of the transition state structures and energies explain these results and energy decomposition analysis calculations reveal unique sensitivities to electrostatic attraction and steric repulsions. Rigorous rate studies of select reactions validated the capacity of the calculations to predict reactivity trends. Additionally, kinetics studies demonstrate the potential for product inhibition in DDQ‐mediated reactions. These studies provide a clear guide to select the optimal oxidant for structurally disparate substrates and lead to predictions of reactivity that were validated experimentally.