bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Incidence of Michigan Emergency Department Visits for Febrile Neutropenia Observed After Public Health Measures for the COVID-19 Pandemic
Authors: Baracy Michael , Hagglund Karen , Corey Logan 
Published: December 2021

Abstract
Importance: Masking and social distancing appear to decrease the of febrile neutropenia in susceptible populations, especially among patients with hematologic malignancies.Objective: To determine whether COVID-19 infection mitigation efforts, namely masking and social distancing, results in a reduction in the incidence of febrile neutropenia.Design: This was a retrospective cohort study comparing the incidence of FN in the 13 months prior to (Year 0) and 13 months following (Year 1) the public health executive orders (PHEO) in Michigan. Data voluntarily submitted by Michigan emergency departments to the National Syndromic Surveillance Program (NSSP) was queried for all ED visits from April 1st, 2019 to March 31st, 2021.Setting: Population based study.Participants: A population-based sample of patients who reported to a Michigan emergency department and on whom data was captured.Intervention(s): Population based masking and social distancing.Main Outcome(s) and Measure(s): The primary study outcome was the incidence of FN as a proportion of emergency visits in the 13-months before and after COVID-19 mitigations efforts, namely masking and social distancing. We hypothesized that there would be a significant decrease in the incidence of FN in the period following the public health executive orders aimed at reducing the spread of the COVID-19 virus.Results: There was a total of 8,979,221 total ED visits captured during the study period. In Year 0 there were 5,073,081 recorded ED visits and 3,906,140 in Year 1, a decrease of 23%. There was a significant reduction in the proportion of total ED visits with a diagnosis of FN, decreasing 13.3% across periods (0.15% vs. 0.13%, p=0.036). In patients with a hematologic malignancy the incidence of FN was significantly lower in the period following PHEO (22% vs 17%, p=0.02, Table 2).Conclusions and Relevance: Our study found a significant association between social distancing and mask guidelines implemented on a large public scale with decreased rates of FN, particularly in those with a hematologic malignancy. These findings may be useful in the design of clinical trials as well as informing future recommendations for the prevention of FN.
Patient Reported Urinary Incontinence and Sexual Impotency Following Multimodality Radical Therapy for Prostate Cancer: An Untold Story of Compound Toxicity?
Authors: Haisraely Ori , Lawrence Yaacov Richard , Lewin Ron , Kaidar-Person Orit , Weiss Ilana , Zimlichman Eyal , Berger Raanan , Symon Zvi 
Published: December 2021

Abstract
Purpose: To evaluate urinary continence and sexual potency following radical prostatectomy and adjuvant radiotherapy.Materials/Methods: Expanded Prostate Cancer Index Composite (EPIC) surveys of patients with localized prostate cancer treated with surgery followed by adjuvant/salvage pelvic radiotherapy (S+RT) were analyzed. A control cohort was primary radiotherapy (RT). Reverse "bifecta" was defined as a score less than 60 in both incontinence and sexual domains. Superior urinary function was defined as a score above 90. The clinically important difference was calculated using a distribution approach.Results: Surveys at least 1 year after treatment were available for 130 S+RT and 374 RT patients. For S+RT vs. RT, the mean urinary incontinence score was 68 [6.25 -100] versus 86.4 [CI-95 39.5-100] (p<0.001), confirming 6.5 points of clinically significant difference. The adjusted odds ratio for superior urinary function was 2.67 (1.7-4.1, p<0.001) for primary radiotherapy. The odds ratio of having both poor urinary and sexual performance (reverse " bifecta") was 0.29 in RT arm (0.14-0.58, p<0.001) when adjusted for age and Androgen Deprivation Therapy (ADT) , group risk stratification, comorbidities and smoking status.Conclusion: In this cross sectional study, Surgery with adjuvant/salvage RT was associated with significantly worse patient reported urinary continence outcomes at 1-year post treatment, lower odds of achieving perfect urinary continence and a threefold risk of reverse ‘bifecta’ with inferior urinary continence and sexual performance. Longitudinal studies of evolving toxicity are required to validate these findings. Patients referred for surgery with a high probability of requiring adjuvant or salvage radiotherapy should be informed regarding the potential composite toxicity of both surgery and radiotherapy.
Effect of Intrauterine Administration of Seminal Plasma for Patients with Recurrent Implantation Failure Before FET: Study Protocol for a Prospective Randomised Controlled Trial
Authors: CUI ling , Wang Fang , Lin Yonghong 
Published: December 2021

Abstract
Background: To assess the effect of intrauterine administration of seminal plasma for patients with recurrent implantation failure before frozen-thawed embryo transfer. Methods: Trial design: This is a parallel group, randomized (1:1 allocation ratio) controlled trial.Participants: All patients will be recruited from Chengdu Women’s and Children’s Central Hospital. Inclusion criteria: 1. Women after IVF/ICSI treatment in Chengdu Women’s and Children’s Central Hospital. 2.Infertile women with a history of recurrent implantation failure. 3.Infertile couples (both male and female) aged between 20 and 39 years;4. Couples who have at least 1 good quality embryos for transfer. 5. Males had negative in infectious disease test. 6. The males have semen. 7. Women who intend to undergo FET after IVF or ICSI or pre-implantation genetic testing for aneuploidy (PGT-A). 8. Competent and able to give informed consent. Intervention and comparator: Treatment group receiving intrauterine administration of seminal plasma before frozen-thawed embryo transfer. Main outcomes: Clinical pregnancy after frozen-thawed embryo transfer. Randomisation: Patients will be randomly allocated to either treatment or control group at 1:1 ratio. Random numbers will be generated by using software SPSS 25.0 performed by an independent statistician from Chengdu Women’s and Children’s Central Hospital. Blinding (masking): Only the data analyst will be blinded to group assignment. Numbers to be randomised (sample size): To account for a 10% dropout rate, we will recruit 174 patients (87 in each group). Trial status: The date of approval is 31rd May 2021, version 2.0. Recruitment started on 1rd June and is expected to end in July 2022. Discussion: Intrauterine administration of seminal plasma before frozen-thawed embryo transfer of patients with recurrent implantation failure may improve clinical pregnancy rate, it has great Page 2 of 14 significance for assisted reproduction. Trial registration: The study protocol has been approved by the ethics committees at Chengdu Women’s and Children’s Central Hospital. The trial was registered at the Chinese Clinical Trial Registry ChiCTR2100046803. Registered on 28 May 2021.
Multicast Scaling in Heterogeneous Wireless Sensor Networks for Security and Time Efficiency
Authors: Vankdothu Ramdas , Abdul Hameed Mohd , Husnah Fatima , Akkala Subbarao 
Published: December 2021

Abstract
Heterogeneous wireless sensor networks (HWSNs) satisfy researchers' requirements for developing real-world solutions that handle unattended challenges. However, the primary constraint of researchers is the privacy of the sensor nodes. It safeguards the sensor nodes and extensions in the HWSNs. Therefore, it is necessary to develop secure operational systems. Multicast scaling with security and time efficiency is described in heterogeneous wireless sensor networks to maximize network performance while also successfully protecting network privacy. This study evaluates the initial security and time efficiency measures, such as execution time, transmission delay, processing delay, congestion level, and trust measure. Subsequently, the optimal location of the heterogeneous nodes is determined using sigmoid-based fuzzy c-means clustering. Finally, successful cluster routing was achieved via support-value-based particle swarm optimization. The experimental results indicate that the proposed strategy surpasses existing strategies in terms of network delivery ratio, end-to-end delay, throughput, packet delivery, and node remaining energy level.
Case Reports On The Multimodal Management of Refractory Chronic Oncological Pain of The Chest Wall: The Use of The Spinal Erector Plane Neurolysis
Authors: Cardenas John , Vargas-Silva Juan Felipe , Ramirez Alejandro 
Published: December 2021

Abstract
Chronic pain of oncological origin is one of the most frequent complications and is difficult to control, that results in a decrease in the quality of life and disability among patients suffering from this pathology. Primary or metastatic tumors originating from lung, colonic, or breast neoplasms can invade the chest wall, causing progressive respiratory pain and symptoms that require multiple interventions to achieve adequate control. Many of these cases presenting with advanced-stage cancer are often incurable; thus, pain management and palliative care are primary objectives. Multimodal management is the strategy of choice in these cases through the participation of a multidisciplinary team. Analgesic therapy covers the use of potent opioids, opioid rotation, adjuvant analgesics, and interventional pain management strategies. We report two cases of chronic oncological pain of the chest wall refractory to pharmacological analgesic management. The optimization of multimodal management and the performance of neurolysis by phenolization of the erector spinae plane achieved an adequate response.
Identification of RHD allelic variants discovered by atypical typing results on the NEO/Echo platforms
Authors: Hudgins J.P. , Matsushita C. , Tuma C.W. , O’Brien L. , Shulman I.A. 
Published: December 2021

Abstract
Some individuals are at risk of anti-D alloimmunization if they inherit D antigens that are qualitatively and/or quantitatively different than wild-type D. We hypothesized that patients who showed serologically inconsistent, weak, or historically discordant D typing results by microplate direct agglutination (MDA) on NEO or Echo (Immucor, Norcross, GA) might be at risk of carrying RHD allelic variants. The present study was designed to evaluate patients with RHD allelic variants if they presented with weakly reactive D typing results on the NEO or Echo. Patients were selected for RHD genotyping if their specimens showed weak reactivity with either series 4 or series 5 anti-D typing reagent, if the strength of reactivity was ≤1+ on the NEO or Echo, or if historical or current D typing results were discordant with current results. Patients selected for RHD genotyping were also tested by saline tube testing using the same anti-D series 4 and 5 reagents. Genotyping was performed by the Immucor genotyping laboratory in Warren, NJ. Of 80 patients whose samples met study inclusion, 52 (65.0%) were found to have RHD allelic variants. Sixteen patients (20.0%) expressed possible Ceppellini effect reactivity. Most importantly, 51.25 percent of the patients who presented with weakly reactive D typing results by MDA testing on the NEO (≤1+) or Echo (≤1+) had RHD allelic variants that were associated with the potential for anti-D alloimmunization. Laboratories that use MDA testing on the Neo or Echo for D typing should consider that female patients of childbearing age might be at risk of anti-D alloimmunization if they are classified as D+ based on weakly reactive D typing results.
The devil is in the details: emerging insights on the relevance of wastewater surveillance for SARS-CoV-2 to public health
Authors: Hrudey Steve E. , Conant Bernadette 
Published: December 2021

Abstract
The severe health consequences and global spread of the COVID-19 pandemic have necessitated the rapid development of surveillance programs to inform public health responses. Efforts to support surveillance capacity have included an unprecedented global research response into the use of genetic signals of SARS-CoV-2 in wastewater following the initial demonstration of the virus' detectability in wastewater in early 2020. The confirmation of fecal shedding of SARS-CoV-2 from asymptomatic, infected and recovering individuals further supports the potential for wastewater analysis to augment public health conventional surveillance techniques based on clinical testing of symptomatic individuals. We have reviewed possible capabilities projected for wastewater surveillance to support pandemic management, including independent, objective and cost-effective data generation that complements and addresses attendant limitations of clinical surveillance, early detection (i.e., prior to clinical reporting) of infection, estimation of disease prevalence, tracking of trends as possible indicators of success or failure of public health measures (mask mandates, lockdowns, vaccination, etc.), informing and engaging the public about pandemic trends, an application within sewer networks to identify infection hotspots, monitoring for presence or changes in infections from institutions (e.g., long-term care facilities, prisons, educational institutions and vulnerable industrial plants) and tracking of appearance/progression of viral variants of concern.
GC/MS screening of buckthorn phytochemicals and their use to synthesize ZnO nanoparticles for photocatalytic degradation of malachite green dye in water
Authors: Hasan Ibrahem M. A. , Tawfik Ahmed R. , Assaf Fawzy H. 
Published: December 2021

AbstractZinc oxide nanoparticles (ZnO NPs) were biosynthesized. According to gas chromatography/mass spectrometry analysis, chalcone, the main phytochemical, is probably complexed with Zn ions that are then oxidized to ZnO NPs by atmospheric O2 during heating. The ZnO NPs were characterized by thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and Brunauer–Emmett–Teller surface area analysis. Sphere-like ZnO NPs were formed with 11 nm mean crystallite size, 5.2 m2 g−1 surface area, and 0.02 cm3 g−1 total pore volume. The synthesized ZnO showed excellent photocatalytic degradation (96.5±0.24% in 1 hour at 25 °C) of malachite green (MG) in aqueous solutions under ultraviolet light at optimum conditions; pH 10, MG initial concentration of 20 mg L−1, and ZnO dose of 1.5 g L−1. Also, ZnO showed very good reusability (92.9± 0.2% after five runs). The experimental data obeyed pseudo-first-order kinetics (R2 = 0.92). The photocatalysis process was dependent on the following species in the order: OH. &gt; electron/positive hole pairs &gt; O2.−. Moreover, photodegradation efficiency decreased in the presence of CO32−, HCO3−, and Cl−, but increased in the presence of NO3− and SO42− ions. Thus, the green synthesized ZnO NPs can be applied as an efficient photocatalyst for the removal of MG from aqueous media.
O movimento “#ELENÃO” e seu apagamento discursivo sob a contranarrativa do “#ELESIM”
Authors: Silva Jamile 
Published: December 2021

RESUMO: Entendendo a língua como um construto de significados e significantes, e que produções discursivas são uma forma de construir narrativas através da produção de sujeitos, ideologicamente interpelados; adentramos à cena político-discursiva das eleições de 2018 com o intuito de proceder a uma investigação, à luz da Análise do Discurso de linha francesa, sobre a construção do contradiscurso que aviltou o êxito da maior manifestação social liderada por mulheres da história do Brasil. Metodologicamente, partimos da análise de enunciados retirados da rede social Facebook, onde ocorreu a maior concentração de apoio a essas narrativas. Com isso, pretendemos estabelecer a correlação entre os discursos antagônicos que culminaram no desfecho das manifestações de 2018, demonstrando, assim, como se deu o processo de (re) significação que reavivou condutas discriminatórias, as quais, até então, pensava-se estarem obsoletas, mas foram reintroduzidas no coletivo nacional. Para tanto, no que diz respeito à construção dos sentidos, memória e sujeito, reportamo-nos a Pêcheux (2010), com reflexões em Courtine (2006), Brandão (2004) e Grigoletto (2005). A partir das análises e verificações, percebe-se a influência ideológica que os arranjos enunciativos exercem sobre as práticas e escolhas discursivas dos sujeitos.

PALAVRAS-CHAVE: Análise do Discurso (AD); movimento #EleNão; sujeito; contradiscurso.
Epigenetic Modulators as Treatment Alternative to Diverse Types of
Cancer
Authors: Gutiérrez Jorseth Rodelo , Salgado Arturo René Mendoza , Arias Marcio De Ávila , San-Juan-Vergara Homero , Rada Wendy Rosales , Gómez Carlos Mario Meléndez 
Published: December 2021

Abstract:
DNA is packaged in an octamer of histones, forming chromatin, a complex of
DNA and proteins. The structural matrix of a chromosome, chromatin and its changes are
now regarded as important factors in controlling gene expression, which has sparked a lot
of interest in understanding genetic pathways governing various diseases, including cancer.
DNA methylation in the CpG dinucleotide as a transcriptional silencing mechanism,
post-translational histone modifications such as acetylation, methylation, and others that
affect chromatin structure, ATP-dependent chromatin remodelling, and miRNA-mediated
gene silencing are all found to be important in various types of cancer. In this review, we
analyze the main alterations in gene expression, epigenetic modification patterns in cancer
cells, the main modulators and inhibitors of each epigenetic mechanism, and the molecular
evolution of the most representative inhibitors, all of which point to a promising future
for HAT, HDAC, non-glycoside DNMT inhibitors, and domain inhibitors.
Remdesivir: Mechanism of Metabolic Conversion from Prodrug to Drug
Authors: Kapoor Saumya , Dubey Gurudutt , Khatun Samima , Bharatam Prasad V. 
Published: December 2021

Background:
Remdesivir (GS-5734) has emerged as a promising drug during the challenging times of
COVID-19 pandemic. Being a prodrug, it undergoes several metabolic reactions before converting to its active
triphosphate metabolite. It is important to establish the atomic level details and explore the energy profile of the
prodrug to drug conversion process.

Methods:
In this work, Density Functional Theory (DFT) calculations were performed to explore the entire metabolic
path. Further, the potential energy surface (PES) diagram for the conversion of prodrug remdesivir to its active
metabolite was established. The role of catalytic triad of Hint1 phosphoramidase enzyme in P-N bond hydrolysis was
also studied on a model system using combined molecular docking and quantum mechanics approach.

Results:
The overall energy of reaction is 11.47 kcal/mol exergonic and the reaction proceeds through many steps
requiring high activation energies. In the absence of a catalyst, the P-N bond breaking step requires 41.78 kcal/mol,
which is reduced to 14.26 kcal/mol in a catalytic environment.

Conclusion:
The metabolic pathways of model system of remdesivir (MSR) were explored completely and potential
energy surface diagrams at two levels of theory, B3LYP/6-311++G(d, p) and B3LYP/6-31+G(d), were established
and compared. The results highlight the importance of an additional water molecule in the metabolic reaction. The PN
bond cleavage step of the metabolic process requires the presence of an enzymatic environment.
MicroRNAs: Beyond Post-transcriptional Regulation of mRNAs
Authors: Viridiana Cervantes-Ayala Andrea , Ángel Velázquez-Flores Miguel , Ruth Ruiz Esparza-Garrido 
Published: December 2021

Abstract:
MicroRNAs (miRNAs), small non-coding RNAs, participate in the transcriptional and post-transcriptional regulation of eukaryotic genes, and are potential biomarkers for diseases. Mature miRNAs can be located in both the nucleus and cytoplasm, where they perform their regulatory function. The discovery of new miRNAs and the identification of their targets and functions are fundamental to understanding the biological processes regulated by them, as well as the role they play in diseases. This present study researched miRNAs function at nuclear level and as circulating molecules.
Acceptance of the Use of Artificial Intelligence in Medicine Among Japan’s Doctors and the Public: A Questionnaire Survey
Authors: Tamori Honoka , Yamashina Hiroko , Mukai Masami , Morii Yasuhiro , Suzuki Teppei , Ogasawara Katsuhiko 
Published: December 2021

Background
The use of artificial intelligence (AI) in the medical industry promises many benefits, so AI has been introduced to medical practice primarily in developed countries. In Japan, the government is preparing for the rollout of AI in the medical industry. This rollout depends on doctors and the public accepting the technology. Therefore it is necessary to consider acceptance among doctors and among the public. However, little is known about the acceptance of AI in medicine in Japan.

Objective
This study aimed to obtain detailed data on the acceptance of AI in medicine by comparing the acceptance among Japanese doctors with that among the Japanese public.

Methods
We conducted an online survey, and the responses of doctors and members of the public were compared. AI in medicine was defined as the use of AI to determine diagnosis and treatment without requiring a doctor. A questionnaire was prepared referred to as the unified theory of acceptance and use of technology, a model of behavior toward new technologies. It comprises 20 items, and each item was rated on a five-point scale. Using this questionnaire, we conducted an online survey in 2018 among 399 doctors and 600 members of the public. The sample-wide responses were analyzed, and then the responses of the doctors were compared with those of the public using t tests.

Results
Regarding the sample-wide responses (N=999), 653 (65.4%) of the respondents believed, in the future, AI in medicine would be necessary, whereas only 447 (44.7%) expressed an intention to use AI-driven medicine. Additionally, 730 (73.1%) believed that regulatory legislation was necessary, and 734 (73.5%) were concerned about where accountability lies. Regarding the comparison between doctors and the public, doctors (mean 3.43, SD 1.00) were more likely than members of the public (mean 3.23, SD 0.92) to express intention to use AI-driven medicine (P<.001), suggesting that optimism about AI in medicine is greater among doctors compared to the public.

Conclusions
Many of the respondents were optimistic about the role of AI in medicine. However, when asked whether they would like to use AI-driven medicine, they tended to give a negative response. This trend suggests that concerns about the lack of regulation and about accountability hindered acceptance. Additionally, the results revealed that doctors were more enthusiastic than members of the public regarding AI-driven medicine. For the successful implementation of AI in medicine, it would be necessary to inform the public and doctors about the relevant laws and to take measures to remove their concerns about them.