bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holocene Evolution of Sea‐Surface Temperature and Salinity in the Gulf of Mexico
Authors: Thirumalai Kaustubh , Richey Julie N. , Quinn Terrence M. 
Published: August 2021

AbstractFlows into and out of the Gulf of Mexico (GoM) are integral to North Atlantic Ocean circulation and help facilitate poleward heat transport in the Western Hemisphere. The GoM also serves as a key source of moisture for most of North America. Modern patterns of sea‐surface temperature (SST) and salinity in the GoM are influenced by the Loop Current, its eddy‐shedding dynamics, and the ensuing interplay with coastal processes. Here, we present sub‐centennial‐scale records of SST and stable oxygen isotope composition of seawater (18Osw; a proxy for salinity) over the past 11,700 years using planktic foraminiferal geochemistry in sediments from the Garrison Basin, northwestern GoM. We measured O and magnesium‐to‐calcium ratios in tests of Globigerinoides ruber (white) to generate quantitative estimates of past sea‐surface conditions. Our results replicate and extend late Holocene reconstructions from the Garrison Basin, using which we then create composites of SST and 18Osw. We find considerable centennial and millennial‐scale variability in both SST and 18Osw, although their evolution over the Holocene is distinct. Whereas mean‐annual SSTs display pronounced millennial‐scale variability, 18Osw exhibits a secular trend spanning multiple millennia and points to increasing northwestern GoM surface salinity since the early Holocene. We then synthesize the available Holocene records from across the GoM and alongside the Garrison Basin composite uncover substantial, yet regionally consistent, spatiotemporal variability. Finally, we discuss the role of the Loop Current and coastal influx of freshwater in imposing these heterogeneities. We conclude that dynamic surface‐ocean changes occurred across the GoM over the Holocene.
MEMS development focusing on collaboration using common facilities: a retrospective view and future directions
Authors: Esashi Masayoshi 
Published: August 2021

AbstractI have been developing MEMS (microelectromechanical systems) technology and supporting the industry through collaboration. A facility was built in house on a 20 mm square wafer for use in prototyping MEMS and ICs (integrated circuits). The constructed MEMS devices include commercialized integrated capacitive pressure sensors, electrostatically levitated rotational gyroscopes, and two-axis optical scanners. Heterogeneous integration, which is a MEMS on an LSI (large-scale integration), was developed for sophisticated systems using LSI made in a foundry. This technology was applied for tactile sensor networks for safe robots, multi FBAR filters on LSI, active-matrix multielectron emitter arrays, and so on. The facility used to produce MEMS on 4- and 6-inch wafers was developed based on an old semiconductor factory and has been used as an open hands-on access facility by many companies. Future directions of MEMS research are discussed.
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer’s disease
Authors: Arroyo-García Luis Enrique , Isla Arturo G. , Andrade-Talavera Yuniesky , Balleza-Tapia Hugo , Loera-Valencia Raúl , Alvarez-Jimenez Laura , Pizzirusso Giusy , Tambaro Simone , Nilsson Per , Fisahn André 
Published: August 2021

AbstractIn Alzheimer’s disease (AD) the accumulation of amyloid-β (Aβ) correlates with degradation of cognition-relevant gamma oscillations. The gamma rhythm relies on proper neuronal spike-gamma coupling, specifically of fast-spiking interneurons (FSN). Here we tested the hypothesis that decrease in gamma power and FSN synchrony precede amyloid plaque deposition and cognitive impairment in AppNL-G-F knock-in mice (AppNL-G-F). The aim of the study was to evaluate the amyloidogenic pathology progression in the novel AppNL-G-F mouse model using in vitro electrophysiological network analysis. Using patch clamp of FSNs and pyramidal cells (PCs) with simultaneous gamma oscillation recordings, we compared the activity of the hippocampal network of wild-type mice (WT) and the AppNL-G-F mice at four disease stages (1, 2, 4, and 6 months of age). We found a severe degradation of gamma oscillation power that is independent of, and precedes Aβ plaque formation, and the cognitive impairment reported previously in this animal model. The degradation correlates with increased Aβ1-42 concentration in the brain. Analysis on the cellular level showed an impaired spike-gamma coupling of FSN from 2 months of age that correlates with the degradation of gamma oscillations. From 6 months of age PC firing becomes desynchronized also, correlating with reports in the literature of robust Aβ plaque pathology and cognitive impairment in the AppNL-G-F mice. This study provides evidence that impaired FSN spike-gamma coupling is one of the earliest functional impairment caused by the amyloidogenic pathology progression likely is the main cause for the degradation of gamma oscillations and consequent cognitive impairment. Our data suggests that therapeutic approaches should be aimed at restoring normal FSN spike-gamma coupling and not just removal of Aβ.
Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4
Authors: Kleiber Thomas , Davidson Guillaume , Mengus Gabrielle , Martianov Igor , Davidson Irwin 
Published: August 2021

AbstractRegulation of gene expression involves a complex and dynamic dialogue between transcription factors, chromatin remodelling and modification complexes and the basal transcription machinery. To address the function of the Taf4 subunit of general transcription factor TFIID in the regulation of insulin signalling, it was inactivated in adult murine pancreatic beta cells. Taf4 inactivation impacted the expression of critical genes involved in beta-cell function leading to increased glycaemia, lowered plasma insulin levels and defective glucose-stimulated insulin secretion. One week after Taf4-loss, single-cell RNA-seq revealed cells with mixed beta cell, alpha and/or delta cell identities as well as a beta cell population trans-differentiating into alpha-like cells. Computational analysis of single-cell RNA-seq defines how known critical beta cell and alpha cell determinants may act in combination with additional transcription factors and the NuRF chromatin remodelling complex to promote beta cell trans-differentiation.
Fingertip advanced glycation end products and psychotic symptoms among adolescents
Authors: Miyashita Mitsuhiro , Yamasaki Syudo , Ando Shuntaro , Suzuki Kazuhiro , Toriumi Kazuya , Horiuchi Yasue , Yoshikawa Akane , Imai Atsushi , Nagase Yukihiro , Miyano Yasuhiro , Inoue Tomoko , Endo Kaori , Morimoto Yuko , Morita Masaya , Kiyono Tomoki , Usami Satoshi , Okazaki Yuji , Furukawa Toshiaki A. , Hiraiwa-Hasegawa Mariko , Itokawa Masanari , Kasai Kiyoto , Nishida Atsushi , Arai Makoto 
Published: August 2021

AbstractCase control studies have suggested that advanced glycation end products play a key role in the pathophysiology of chronic schizophrenia. However, the longitudinal association between advanced glycation end products and psychotic symptoms among drug-naïve adolescents remains unclear. This study examined whether advanced glycation end products could predict the trajectory of psychotic symptoms in drug-naive adolescents using data from prospective population-based biomarker subsample study of the Tokyo Teen Cohort. A total of 277 community-dwelling adolescents aged 13 years without antipsychotic medication were analyzed. Fingertip advanced glycation end products were measured in adolescents using noninvasive technology that can be used quickly. The trajectory of psychotic symptoms in a 12-month follow-up was assessed by experienced psychiatrists using a semi-structured interview. Of the 277 participants, 13 (4.7%) experienced persistent psychotic symptoms (psychotic symptoms at baseline and follow-up), 65 (23.5%) experienced transient psychotic symptoms (psychotic symptoms at baseline or follow-up), and 199 (71.8%) did not have psychotic symptoms. Multinomial logistic regression analysis adjusted for age and sex revealed that baseline fingertip advanced glycation end products might predict the risk of persistent psychotic symptoms (odds ratio = 1.68; 95% confidence interval, 1.05–2.69; P = 0.03). Altogether, fingertip advanced glycation end products potentially predicted the trajectory of psychotic symptoms among drug-naive adolescents, which indicated its involvement in the pathophysiology of early psychosis. Further studies are required to identify strategies to reduce adolescent advanced glycation end products, which may contribute to preventing the onset of psychosis.
OPTIMADE, an API for exchanging materials data
Authors: Andersen Casper W. , Armiento Rickard , Blokhin Evgeny , Conduit Gareth J. , Dwaraknath Shyam , Evans Matthew L. , Fekete Ádám , Gopakumar Abhijith , Gražulis Saulius , Merkys Andrius , Mohamed Fawzi , Oses Corey , Pizzi Giovanni , Rignanese Gian-Marco , Scheidgen Markus , Talirz Leopold , Toher Cormac , Winston Donald , Aversa Rossella , Choudhary Kamal , Colinet Pauline , Curtarolo Stefano , Di Stefano Davide , Draxl Claudia , Er Suleyman , Esters Marco , Fornari Marco , Giantomassi Matteo , Govoni Marco , Hautier Geoffroy , Hegde Vinay , Horton Matthew K. , Huck Patrick , Huhs Georg , Hummelshøj Jens , Kariryaa Ankit , Kozinsky Boris , Kumbhar Snehal , Liu Mohan , Marzari Nicola , Morris Andrew J. , Mostofi Arash A. , Persson Kristin A. , Petretto Guido , Purcell Thomas , Ricci Francesco , Rose Frisco , Scheffler Matthias , Speckhard Daniel , Uhrin Martin , Vaitkus Antanas , Villars Pierre , Waroquiers David , Wolverton Chris , Wu Michael , Yang Xiaoyu 
Published: August 2021

AbstractThe Open Databases Integration for Materials Design (OPTIMADE) consortium has designed a universal application programming interface (API) to make materials databases accessible and interoperable. We outline the first stable release of the specification, v1.0, which is already supported by many leading databases and several software packages. We illustrate the advantages of the OPTIMADE API through worked examples on each of the public materials databases that support the full API specification.
Thoracic weighting of restrained subjects during exhaustion recovery causes loss of lung reserve volume in a model of police arrest
Authors: Campbell Mark , Dakin Roslyn , Stowe Symon , Burton Kira , Raven Brianna , Mapani Malitela , Dawson Jeff W. , Adler Andy 
Published: August 2021

AbstractRestraint asphyxia has been proposed as a mechanism for some arrest-related deaths that occur during or shortly after a suspect is taken into custody. Our analysis of the literature found that prone positioning, weight applied to the back, recovery after simulated pursuit, and restraint position have led to restrictive, but non life-threatening respiratory changes when tested in subsets. However, the combined effects of all four parameters have not been tested together in a single study. We hypothesized that a complete protocol with high-sensitivity instrumentation could improve our understanding of breathing physiology during weighted restraint. We designed an electrical impedance tomography (EIT)-based protocol for this purpose and measured the 3D distribution of ventilation within the thorax. Here, we present the results from a study on 17 human subjects that revealed FRC declines during weighted restrained recovery from exercise for subjects in the restraint postures, but not the control posture. These prolonged FRC declines were consistent with abdominal muscle recruitment to assist the inspiratory muscles, suggesting that subjects in restraint postures have increased work of breathing compared to controls. Upon removal of the weighted load, lung reserve volumes gradually increased for the hands-behind-the-head restraint posture but continued to decrease for subjects in the hands-behind-the-back restraint posture. We discuss the possible role this increased work of breathing may play in restraint asphyxia.
Topological analysis of interaction patterns in cancer-specific gene regulatory network: persistent homology approach
Authors: Masoomy Hosein , Askari Behrouz , Tajik Samin , Rizi Abbas K. , Jafari G. Reza 
Published: August 2021

AbstractIn this study, we investigated cancer cellular networks in the context of gene interactions and their associated patterns in order to recognize the structural features underlying this disease. We aim to propose that the quest of understanding cancer takes us beyond pairwise interactions between genes to a higher-order construction. We characterize the most prominent network deviations in the gene interaction patterns between cancer and normal samples that contribute to the complexity of this disease. What we hope is that through understanding these interaction patterns we will notice a deeper structure in the cancer network. This study uncovers the significant deviations that topological features in cancerous cells show from the healthy one, where the last stage of filtration confirms the importance of one-dimensional holes (topological loops) in cancerous cells and two-dimensional holes (topological voids) in healthy cells. In the small threshold region, the drop in the number of connected components of the cancer network, along with the rise in the number of loops and voids, all occurring at some smaller weight values compared to the normal case, reveals the cancerous network tendency to certain pathways.
Deep learning and citizen science enable automated plant trait predictions from photographs
Authors: Schiller Christopher , Schmidtlein Sebastian , Boonman Coline , Moreno-Martínez Alvaro , Kattenborn Teja 
Published: August 2021

AbstractPlant functional traits (‘traits’) are essential for assessing biodiversity and ecosystem processes, but cumbersome to measure. To facilitate trait measurements, we test if traits can be predicted through visible morphological features by coupling heterogeneous photographs from citizen science (iNaturalist) with trait observations (TRY database) through Convolutional Neural Networks (CNN). Our results show that image features suffice to predict several traits representing the main axes of plant functioning. The accuracy is enhanced when using CNN ensembles and incorporating prior knowledge on trait plasticity and climate. Our results suggest that these models generalise across growth forms, taxa and biomes around the globe. We highlight the applicability of this approach by producing global trait maps that reflect known macroecological patterns. These findings demonstrate the potential of Big Data derived from professional and citizen science in concert with CNN as powerful tools for an efficient and automated assessment of Earth’s plant functional diversity.
Bitmap and vectorial hologram recording by using femtosecond laser pulses
Authors: Kotsiuba Y. , Hevko I. , Bellucci S. , Gnilitskyi I. 
Published: August 2021

AbstractIn this paper, we present two approaches for recording a quasi-hologram on the steel surface by femtosecond laser pulses. The recording process is done by rotating the polarization of the laser beam by a half-wave plate or a spatial light modulator (SLM), so we can control the spatial orientation of the formed laser-induced periodic surface structures (LIPSS). Two different approaches are shown, which use vector and bitmap images to record the hologram. For the first time to our knowledge, we managed to record a hologram of a bitmap image by continuously adjusting the laser beam polarization by SLM during scanning. The developed method can substantially improve hologram recording technology by eliminating complex processing procedures, which can lead to increasing the fabrication speed and reducing the cost.
Accelerated clearing and molecular labeling of biological tissues using magnetohydrodynamic force
Authors: Dwyer Joseph , Ramirez M. Desmond , Katz Paul S. , Karlstrom Rolf O. , Bergan Joseph 
Published: August 2021

AbstractTechniques used to clear biological tissue for fluorescence microscopy are essential to connect anatomical principles at levels ranging from subcellular to the whole animal. Here we report a simple and straightforward approach to efficiently render opaque tissue samples transparent and show that this approach can be modified to rapidly label intact tissue samples with antibodies for large volume fluorescence microscopy. This strategy applies a magnetohydrodynamic (MHD) force to accelerate the removal of lipids from tissue samples at least as large as an intact adult mouse brain. We also show that MHD force can be used to accelerate antibody penetration into tissue samples. This strategy complements a growing array of tools that enable high-resolution 3-dimensional anatomical analyses in intact tissues using fluorescence microscopy. MHD-accelerated clearing is simple, fast, reliable, inexpensive, provides good thermal regulation, and is compatible with existing strategies for high-quality fluorescence microscopy of intact tissues.
Disgusting odours affect the characteristics of the Adaptive Force in contrast to neutral and pleasant odours
Authors: Schaefer Laura V. , Dech Silas , Aehle Markus , Bittmann Frank N. 
Published: August 2021

AbstractThe olfactomotor system is especially investigated by examining the sniffing in reaction to olfactory stimuli. The motor output of respiratory-independent muscles was seldomly considered regarding possible influences of smells. The Adaptive Force (AF) characterizes the capability of the neuromuscular system to adapt to external forces in a holding manner and was suggested to be more vulnerable to possible interfering stimuli due to the underlying complex control processes. The aim of this pilot study was to measure the effects of olfactory inputs on the AF of the hip and elbow flexors, respectively. The AF of 10 subjects was examined manually by experienced testers while smelling at sniffing sticks with neutral, pleasant or disgusting odours. The reaction force and the limb position were recorded by a handheld device. The results show, inter alia, a significantly lower maximal isometric AF and a significantly higher AF at the onset of oscillations by perceiving disgusting odours compared to pleasant or neutral odours (p < 0.001). The adaptive holding capacity seems to reflect the functionality of the neuromuscular control, which can be impaired by disgusting olfactory inputs. An undisturbed functioning neuromuscular system appears to be characterized by a proper length tension control and by an earlier onset of mutual oscillations during an external force increase. This highlights the strong connection of olfaction and motor control also regarding respiratory-independent muscles.
Secular trends in the prevalence of abdominal obesity among Chinese adults with normal weight, 1993–2015
Authors: Sun Xingxing , Liu Zhelong , Du Tingting 
Published: August 2021

AbstractA considerable chronic disease burden existed in people with normal body mass index (BMI), it is imperative to study the prevailing trends in abdominal obesity among Chinese people with normal BMI. Hence, we aimed to analyze updated prevalence data on abdominal obesity trends among Chinese adults with a normal BMI. We used data from the China Health and Nutrition Survey (CHNS) conducted between 1993 and 2015. Abdominal obesity is defined as waist circumference (WC) ≥ 90 cm for men and ≥ 80 cm for women following the International Diabetes Federation recommendations for Asians. Over the 23-year period, the age-standardized mean WC values showed a significant increasing trend among Chinese adults with BMI < 25 kg/m2, with the mean value increased from 74.0 cm to 78.5 cm (P for trend < 0.0001). During the period of 1993–2015, the age-standardized prevalence of abdominal obesity increased from 12.1 to 26.0% (P for trend < 0.0001). Significant increases were observed in both sexes, all age groups, rural and urban residents, and all educational attainment groups (all P for trends < 0.0001), with a greater relative increase noted among men, younger participants, and rural residents. Similar significant trends were noted when a more stringent BMI < 23 kg/m2 cut point (Asian cut point) was applied. A low magnitude of overlap existed between abdominal obesity and general obesity, irrespective of the criteria used. The mean WC and the prevalence of abdominal obesity among Chinese adults with normal BMI increased continuously from 1993 to 2015. The upward trends were noted in both sexes, all age groups, rural and urban regions, and all educational attainment groups. Our estimates emphasize the importance of adding WC in addition to BMI as measures to monitor obesity prevalence.
Uneven declines between corals and cryptobenthic fish symbionts from multiple disturbances
Authors: Froehlich Catheline Y. M. , Klanten O. Selma , Hing Martin L. , Dowton Mark , Wong Marian Y. L. 
Published: August 2021

AbstractWith the onset and increasing frequency of multiple disturbances, the recovery potential of critical ecosystem-building species and their mutual symbionts is threatened. Similar effects to both hosts and their symbionts following disturbances have been assumed. However, we report unequal declines between hosts and symbionts throughout multiple climate-driven disturbances in reef-building Acropora corals and cryptobenthic coral-dwelling Gobiodon gobies. Communities were surveyed before and after consecutive cyclones (2014, 2015) and heatwaves (2016, 2017). After cyclones, coral diameter and goby group size (i.e., the number of gobies within each coral) decreased similarly by 28–30%. After heatwave-induced bleaching, coral diameter decreased substantially (47%) and gobies mostly inhabited corals singly. Despite several coral species persisting after bleaching, all goby species declined, leaving 78% of corals uninhabited. These findings suggest that gobies, which are important mutual symbionts for corals, are unable to cope with consecutive disturbances. This disproportionate decline could lead to ecosystem-level disruptions through loss of key symbiont services to corals.
Negative media portrayals of immigrants increase ingroup favoritism and hostile physiological and emotional reactions
Authors: Conzo Pierluigi , Fuochi Giulia , Anfossi Laura , Spaccatini Federica , Mosso Cristina Onesta 
Published: August 2021

AbstractAnti-immigration rhetoric in the mass media has intensified over the last two decades, potentially decreasing prosocial behavior and increasing outgroup hostility toward immigrants, and fostering ingroup favoritism toward natives. We aim to understand the effects of negative and positive discourses about immigration on prosociality at different levels of societal ethnic diversity. In two studies (student sample, nationally representative sample), we conduct a survey and a 3X3 between-subject experiment, including money-incentivized behavioral games measuring prosociality. We manipulate media representations of immigrants and the probability of interacting with immigrants (the latter measuring diversity). Results show that negative news affects prosociality as a function of the probability of interacting with immigrants. Negative portrayals increase altruism and trustworthiness in ethnically homogenous settings relative to unknown and ethnically-mixed contexts. These results are stronger for right-wing and high-prejudice respondents. Moreover, negative media portrayals of immigrants increase the testosterone-cortisol ratio, which is a proxy for proneness to social aggression. Negative news also increases outgroup-related perceived health risk, outgroup anxiety and outgroup threat less in ethnically-homogeneous contexts. Overall, negative portrayals of immigrants generate physiological and emotional hostility toward the outgroup, and ingroup favoritism in economic transactions, possibly determining efficiency losses in ethnically-diverse markets, relative to ethnically-homogeneous markets.