bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravity magnetic resonance imaging measurement of muscle pump change accompanied by aging and posture
Authors: Fujii Taiga , Ohno Naoki , Sawazaki Takuto , Ogura Kohei , Miyati Tosiaki , Sugama Junko 
Published: January 2021

AbstractAimTo date no age‐comparative study has been reported about effect of exercise on muscle pump action change, while its effect is suggested to differ in ages. This study aims to clarify the changes in muscle pump action with aging by measuring the muscle and vein area, and blood flow in lower legs.MethodsSubjects were healthy volunteers and consisted of three groups: young age group (N = 20), middle age group (N = 20) and old age group (N = 16). The lower leg flexor muscle area and popliteal vein area were measured by using T1‐weighed magnetic resonance imaging at the condition pre‐ and post‐ankle exercise in three positions. Moreover, popliteal blood flow velocity was also measured using phase contrast magnetic resonance imaging.ResultsThe elderly had the highest number of individuals who had exercise habits (p < .001). In a multiple linear regression analysis, sitting posture, leg muscle volume, and rate of change in the soleus muscle were significantly related to blood flow velocity change.ConclusionsNo difference was found in the changes in muscle pump action with age. The study results suggested that elderly people with exercise habits might be able to maintain the muscle pump action.
“We’re just two people in a relationship”: A qualitative exploration of emotional bond and fairness experiences between transgender women and their cisgender partners
Authors: Coppola Jennifer , Gangamma Rashmi , Hartwell Erica 
Published: January 2021

AbstractTrans‐including couples experience systemic marginalization impacting their relationships, yet studies on these relationships or narratives of strength are few. The purpose of this qualitative study was to explore emotional bonding and perceptions of fairness between transgender women and their cisgender partners. Interpretative Phenomenological Analysis was utilized to answer the research question: What are the experiences of emotional bond and fairness between transgender women and their cisgender partners? This research was situated within frameworks of minority stress, romantic attachment, and contextual therapy. Seven couples of transgender women and cisgender partners were interviewed. Three themes emerged: Minority Stress Contexts and Relational Strengths; The Experience of Emotional Bond; and Negotiating Balance. Processes of boundary creation, attunement, affirmations, and balance of care were noted. Findings reframe partner relationships as opportunities to construct transphobia‐resistant and resilient narratives. Recommendations for clinicians include prioritizing the couple subsystem as an avenue for building resilience against minority stress.
Desmoplastic mesenteric lesions do not respond radiographically to peptide receptor radionuclide therapy
Authors: Pelle Eleonora , Al‐Toubah Taymeyah , Morse Brian , El‐Haddad Ghassan , Strosberg Jonathan 
Published: January 2021

Abstract177Lu‐Dotatate treatment is indicated for progressive, well‐differentiated, small bowel neuroendocrine tumours) NETs. These tumours often metastasise to mesenteric lymph nodes and produce a desmoplastic reaction, consisting of tumour cells interspersed with fibrotic tissue. We hypothesised that, in patients treated with 177Lu‐Dotatate, mesenteric tumours would remain stable even as liver tumour size changes were observed. We retrospectively reviewed the records of all patients treated with 177Lu‐Dotatate between April 2018 and December 2019. Among patients with desmoplastic mesenteric tumours and liver metastases, we evaluated changes in tumour size of mesenteric and liver lesions based on pre‐ and post‐treatment anatomic scans. As a result of the infrequency of objective radiographic response, any reported changes in tumour size were considered significant. Twenty‐one patients met the inclusion criteria: nine had evidence of shrinkage of liver lesion(s), one had mild progression of liver lesions, seven had stable hepatic disease and four had a mixed hepatic response. Two of the patients with hepatic tumour shrinkage met the criteria for a partial response via RECIST 1.1 (https://recist.eortc.org). Desmoplastic mesenteric lesions remained unchanged in size, regardless of the changes detected in liver lesions.In conclusion, 177Lu‐Dotatate does not impact desmoplastic mesenteric tumours which are typically associated with midgut NETs. Patients whose disease is predominantly confined to desmoplastic mesenteric lesions are unlikely to respond radiographically to peptide receptor radionuclide therapy. Moreover, the inclusion of desmoplastic mesenteric lesions as target lesions in RECIST measurements tends to increase rates of disease stability vs response or progression.
Characteristics of Advance Care Planning Interventions Across Dementia Stages: A Systematic Review
Authors: Kim Hyejin , Cho Jeonghyun , Park Won Seok , Kim Sang Suk 
Published: January 2021

AbstractPurposeLittle is known regarding how advance care planning (ACP) interventions change with the progression of dementia. Thus, the primary purpose of this systematic review is to compare characteristics of ACP interventions across dementia stages. We also identify the role of nurses in implementing ACP interventions for persons with dementia and their surrogates.DesignA systematic review of ACP intervention studies.MethodsAfter searching PubMed, Web of Science, EMBASE, PsycArticles, the Cumulative Index to Nursing and Allied Health Literture (CINAHL), and Scopus, the final sample included 11 studies representing 10 interventions. We conducted a quality assessment and extracted data on dementia stage, intervention characteristics, and the role of nurses in the intervention. The extracted data were categorized according to stages of dementia, and analyzed to identify commonalities and differences between intervention characteristics.FindingsThree ACP interventions focused on mild dementia and seven on advanced dementia. We observed four primary findings. First, we found a major difference in intervention recipients between the two dementia stages. Second, most ACP interventions included structured discussions regarding the person’s life goals and values, goals of care, and preferences concerning future care via individual, face‐to‐face interactions. Third, ACP interventions designed to promote ongoing discussions and documentation were lacking. Finally, nurses played important roles in implementing ACP interventions.ConclusionsThe findings suggest more nurse‐led, dementia‐related ACP interventions. In addition, ACP interventions should promote ongoing discussions and documentation and target persons with dementia and their surrogates in various countries.Clinical RelevanceMany persons with dementia and their surrogates have limited knowledge about ACP; thus, more nurse‐led ACP programs that reflect dementia stages may help them prepare for the situations in which persons with dementia lack decision‐making capacity.
Association between polysomnographic parameters of sleep bruxism and attrition‐type tooth wear
Authors: Kapagiannidou Despoina , Koutris Michail , Wetselaar Peter , Visscher Corine Miriam , van der Zaag Jacques , Lobbezoo Frank 
Published: January 2021

AbstractBackgroundClinically, sleep bruxism is considered to be associated with the presence of tooth wear, but strong evidence is still lacking.ObjectiveTo examine whether an association exists between polysomnographic parameters, recorded from patients with possible sleep bruxism and tooth wear.MethodsSixty‐three possible sleep bruxers (19 males and 44 females, mean ± SD age = 38.5 ± 11.4 years) were recruited among patients attending the Clinic for orofacial pain and dysfunction of the Academic Centre for Dentistry Amsterdam (ACTA). The incisal/occlusal tooth wear was recorded for each tooth clinically, using a 5‐point ordinal scale. Subsequently, all patients underwent an one‐night ambulatory polysomnographic recording, during which the number of bruxism episodes per hour of sleep (Epi/h), the number of bruxism bursts per hour of sleep (Bur/h), and the bruxism time index (BTI) were recorded and analysed. Logistic regression analysis was performed using the presence of tooth wear as the dependent variable, the polysomnographic recordings as independent variables, and corrected for age and gender. The Bur/h and BTI were removed from the analyses due to collinearity with the Epi/h. Additionally, the polysomnographic recordings were also tested for possible association with self‐reported grinding of the teeth during sleep.ResultsNo significant correlation was found between tooth wear and Epi/h (P = 0.381). In addition, the presence of tooth wear was not associated with self‐reported parafunctions.ConclusionClinically measured tooth wear and self‐reported parafunction seem not be related to the polysomnographic parameters of possible sleep bruxism.
Critical coverage: How the media criticize supreme courts—Evidence from Israel
Authors: Bogoch Bryna , Holzman‐Gazit Yifat 
Published: January 2021

AbstractThis paper examines media criticism of the Israeli Supreme Court from 2002 to 2011 in two newspapers. We analyze the nature and patterns of press criticism in different contexts by 1) distinguishing between diffuse and specific criticism and 2) by analyzing criticism separately from political framing and the tone of the article. We find that the increase in diffuse criticism and political framing over time was often balanced with counter‐criticism, resulting in a neutral or even positive tone toward the Court. This complex picture enables a more sophisticated understanding of the nature and implications of criticism of supreme courts in the press.
Cerebral microcirculation in glioblastoma: A major determinant of diagnosis, resection, and drug delivery
Authors: Nagaraja Tavarekere N. , Lee Ian Y. 
Published: January 2021

AbstractGlioblastoma (GBM) is the most common primary brain tumor with a dismal prognosis. Current standard of treatment is safe maximal tumor resection followed by chemotherapy and radiation. Altered cerebral microcirculation and elevated blood‐tumor barrier (BTB) permeability in tumor periphery due to glioma‐induced vascular dysregulation allow T1 contrast‐enhanced visualization of resectable tumor boundaries. Newer tracers that label the tumor and its vasculature are being increasingly used for intraoperative delineation of glioma boundaries for even more precise resection. Fluorescent 5‐aminolevulinic acid (5‐ALA) and indocyanine green (ICG) are examples of such intraoperative tracers. Recently, magnetic resonance imaging (MRI)–based MR thermometry is being employed for laser interstitial thermal therapy (LITT) for glioma debulking. However, aggressive, fatal recurrence always occurs. Postsurgical chemotherapy is hampered by the inability of most drugs to cross the blood‐brain barrier (BBB). Understanding postsurgical changes in brain microcirculation and permeability is crucial to improve chemotherapy delivery. It is important to understand whether any microcirculatory indices can differentiate between true recurrence and radiation necrosis. LITT leads to peri‐ablation BBB opening that persists for several weeks. Whether it can be a conduit for chemotherapy delivery is yet to be explored. This review will address the role of cerebral microcirculation in such emerging ideas in GBM diagnosis and therapy.
The reasonable patient – A Swedish discursive construction
Authors: Boman Åse , Dahlborg Elisabeth , Eriksson Henrik , Tengelin Ellinor 
Published: January 2021

AbstractThe aim of this study was to analyse how the patient is constructed and socially positioned in Swedish patient information. Corpus‐assisted critical discourse analysis methodology was utilised on a sample of 56 online patient information texts about cancer containing a total of 126,711 words. The findings show an overarching discourse of informed consent guided by specific features to produce a patient norm that we name “the reasonable patient”, who is receptive to arguments, emotionally restrained and makes decisions based on information. Through the discourse of informed consent, the norm of the reasonable patient emerges, apparently to even out the imbalance of power between patient and professional, but in reality, more likely to construct a patient who is easily controlled and managed. When the self‐responsibility towards health is incorporated into the everyday domestic spaces via digital health technologies, the ideas and concepts of the patient role need to be reconsidered based on these new conditions. We conclude that it is important for nursing researchers to broaden the research on patients to include the relationship of power created through language. This study demonstrates both methodological and empirical possibilities to do so.
Regulation of flowering time by ambient temperature: repressing the repressors and activating the activators
Authors: Jin Suhyun , Ahn Ji Hoon 
Published: January 2021

SummaryPlants display remarkable developmental flexibility as they continuously sense and respond to changes in their environment. This flexibility allows them to select the optimal timing for critical developmental decisions such as when to flower. Ambient temperature is a major environmental factor that influences flowering; the mechanisms involved in ambient temperature‐responsive flowering have attracted particular attention as a consequence of the effects of global climate change on temperature. PHYTOCHROME INTERACTING FACTOR 4 and alternative splicing of FLOWERING LOCUS M affect temperature‐responsive flowering; however, the exact temperature‐sensing mechanism in plants remains elusive. Further study of these molecular mechanisms will contribute to our understanding of how plants sense ambient temperature and respond via diverse biological signaling cascades.
Stable, fertile lines produced by hybridization between allotetraploids Brassica juncea (AABB) and Brassica carinata (BBCC) have merged the A and C genomes
Authors: Katche Elvis , Gaebelein Roman , Idris Zurianti , Vasquez‐Teuber Paula , Lo Yu‐tzu , Nugent David , Batley Jacqueline , Mason Annaliese S. 
Published: January 2021

Summary

Many flowering plant taxa contain allopolyploids that share one or more genomes in common. In the Brassica genus, crop species Brassica juncea and Brassica carinata share the B genome, with 2n = AABB and 2n = BBCC genome complements, respectively. Hybridization results in 2n = BBAC hybrids, but the fate of these hybrids over generations of self‐pollination has never been reported.

We produced and characterized B. juncea × B. carinata (2n = BBAC) interspecific hybrids over six generations of self‐pollination under selection for high fertility using a combination of genotyping, fertility phenotyping, and cytogenetics techniques.

Meiotic pairing behaviour improved from 68% bivalents in the F1 to 98% in the S5/S6 generations, and initially low hybrid fertility also increased to parent species levels. The S5/S6 hybrids contained an intact B genome (16 chromosomes) plus a new, stable A/C genome (18–20 chromosomes) resulting from recombination and restructuring of A and C‐genome chromosomes.

Our results provide the first experimental evidence that two genomes can come together to form a new, restructured genome in hybridization events between two allotetraploid species that share a common genome. This mechanism should be considered in interpreting phylogenies in taxa with multiple allopolyploid species.
Anxiety and cognitive load affect upper limb motor control in Parkinson's disease during medication phases
Authors: Nodehi Zahra , Mehdizadeh Hajar , Azad Akram , Mehdizadeh Maryam , Reyhanian Elham , Saberi Zakieh Sadat , Meimandi Mahsa , Soltanzadeh Akbar , Roohi‐Azizi Mahtab , Vasaghi‐Gharamaleki Behnoosh , Parnianpour Mohamad , Khalaf Kinda , Taghizadeh Ghorban 
Published: January 2021

AbstractAnxiety is among the most debilitating nonmotor symptoms of Parkinson's disease (PD). This study aimed to determine how PD patients with low and high levels of anxiety (LA‐PD and HA‐PD, respectively) compare with age‐ and sex‐matched controls at the level of motor control of reach‐to‐grasp movements during single‐ and dual‐task conditions with varying complexity. Reach‐to‐grasp movement kinematics were assessed in 20 LA‐PD, 20 HA‐PD, and 20 sex‐ and age‐matched healthy controls under single‐ as well as easy and difficult dual‐task conditions. Assessment of PD patients was performed during both the on‐ and off‐drug phases. The results obtained during dual‐task conditions reveal deficits in both reach and grasp components for all three groups (e.g., decreased peak velocity and delayed maximum hand opening). However, these deficits were significantly greater in the PD groups, especially in the HA‐PD group. Although dopaminergic medication improved reach kinematics, it had no effect on grasp kinematics. The results of our study indicated that high levels of anxiety may enhance the inefficiency of upper limb motor control in PD patients, especially during high demanding cognitive conditions, and should, therefore, be considered in the assessment and planning of interventions for upper limb function in these patients.
The Consumption Euler Equation or the Keynesian Consumption Function?*
Authors: Boug Pål , Cappelen Ådne , Jansen Eilev S. , Swensen Anders Rygh 
Published: January 2021

AbstractWe formulate a general cointegrated vector autoregressive (CVAR) model that nests both a class of consumption Euler equations and various Keynesian‐type consumption functions. Using likelihood‐based methods and Norwegian data, we find support for cointegration between consumption, income and wealth once a structural break around the time of the financial crisis is allowed for. The fact that consumption cointegrates with both income and wealth and not only with income points to the empirical irrelevance of an Euler equation. Moreover, we find that consumption equilibrium corrects to changes in income and wealth, but not that income equilibrium corrects to changes in consumption, which would follow from an Euler equation. We also find that most of the parameters stemming from the class of Euler equations are not corroborated by the data when conditional expectations of future consumption and income in CVAR models are considered. Only habit formation seems important in explaining Norwegian consumer behaviour. Our estimated conditional Keynesian‐type consumption function implies a first year marginal propensity to consume (MPC) out of income of close to 40%.
Arthroscopic Reconstruction of Posterior Cruciate Ligament with Embedded Tibial Tendon Bolt
Authors: Li Hua‐zhe , Yu Cong , Zhang Zhi‐tao , Yan Shi , Liao Yun‐jian , Lu Dai‐feng 
Published: January 2021

ObjectiveTo evaluate the effect of newly designed arthroscopic reconstruction of posterior cruciate ligament (PCL) using tibial tendon bolt.MethodsThe effects of embedded tendon pin were observed by X‐ray of knee joint. From October 2010 to September 2015, 51 PCL injury patients who met the inclusion criteria were enrolled in this retrospective study. The arthroscopically assisted reconstruction of the PCL with tibial tendon bolt was performed on all patients. Visual Analog Scale (VAS) pain score, Tegner activity score, Lysholm score, International Knee Documentation Committee (IKDC) assessment, posterior drawer test (PDT), and KT‐1000 activity score were evaluated preoperatively and at 1‐year postoperative and 3‐year postoperative.ResultsThe preoperative, 1‐year postoperative, and 3‐year postoperative IKDC score (15.8% ± 14.8%, 89.6% ± 5.8%, and 86.8% ± 5.4%), Lysholm score (17.4 ± 10.7, 91.2 ± 2.8, and 88.2 ± 3.1), VAS score (5.8 ± 1.2, 1.3 ± 0.5, and 0.6 ± 0.5), Tegner activity score (1.2 ± 0.8, 8.1 ± 0.8, and 7.4 ± 0.8), and KT‐1000 score (15.6 ± 3.6, 4.5 ± 2.4, and 5.4 ± 1.8) were obtained. There were significant differences in these outcomes among preoperative, 1‐year postoperative, and 3‐year postoperative (all P < 0.0001). After 1‐ and 3‐year surgery, 31 (60.8%) and 26 (51.0%) patients had the negative PDT, indicating that the PCL injury was improved. There were no postoperative complications.ConclusionThe application of tendon pin fixed by tibial inlay 8‐shaped tibial tunnel to reconstruct PCL was an effective, simple, and safe surgical procedure for PCL injury.
No impact of neonicotinoids on male solitary bees Osmia cornuta under semi‐field conditions
Authors: Strobl Verena , Bruckner Selina , Radford Sarah , Wolf Sarah , Albrecht Matthias , Villamar‐Bouza Laura , Maitip Jakkrawut , Kolari Eleonora , Chantawannakul Panuwan , Glauser Gaétan , Williams Geoffrey R. , Neumann Peter , Straub Lars 
Published: January 2021

AbstractThe ubiquitous use of agrochemicals is one driver for the ongoing loss of insect biomass and diversity. Data show that field‐realistic concentrations of neonicotinoid insecticides can negatively affect both population density and the fitness of solitary bees. However, the underlying mechanisms for these effects remain poorly understood. Here, using an established semi‐field experimental set‐up and Osmia cornuta as a solitary bee model, we examined the effects of field‐realistic concentrations of a common neonicotinoid insecticide (clothianidin) on male larvae and adults. Besides measuring lethal (i.e., overwintering success and adult survival) and sub‐lethal endpoints (i.e., emergence mass and emergence duration), we examined, for the first time, potential effects on the male reproductive physiology of a solitary bee (i.e., sperm quantity and viability). The data revealed no significant effects on any of the measured response variables. This may be due to the low degree of clothianidin exposure (0.56 ng g−1) and/or the apparent low susceptibility of solitary bee larvae to neonicotinoids. Furthermore, it is conceivable that ideal foraging conditions, combined with optimal weather and lack of other environmental stressors, may have improved the ability of bees to cope with the insecticide. To reliably assess and understand the environmental hazards of agrochemicals, a holistic approach, including laboratory, semi‐field and field data is required. Knowledge of underlying mechanisms will help to mitigate the current global declines of insect populations.