bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTIPLASMODIAL AND Β-HEMATIN INHIBITORY POTENTIAL OF THE EXTRACT AND SOLVENT FRACTIONS OF NEPHROLEPIS UNDULATA
Authors: AKOSILE Oluwayomi Rebecca , Odediran Samuel Akintunde , BAMIGBOYE Rachael Adebola , ADEBAYO Praise Adetola , ADEBOLU Deborah Abimbola 
Published: December 2024

Background: The beta-hematin-inhibitory potential of the extract and the partitioned fractions of Nephrolepis undulata have not been determined, neither the likely constituents responsible for the observed in vivo antiplasmodial activities identified, hence this study.
Materials and Methods: The methanol extract of N. undulata (MNU), was evaporated in vacuo and subsequently partitioned to give HNU (n hexane), DNU (dichloromethane), ENU (ethyl acetate) and ANU (aqueous phase) which were investigated in vivo in mice at 0-800mg/kg against chloroquine-sensitive Plasmodium berghei berghei using Peter’s four-day test. The Beta hematin inhibition assay was carried out on the extract and the fractions as well as Gas Chromatography Mass Spectroscopy for identification of the chemical constituents. Normal saline and chloroquine (10mg/kg) were negative and positive controls, respectively. All the results were subjected to statistical analysis using ANOVA with Student Newman Keul’s as post hoc test.
Results: The partitioned fractions elicited comparatively lower percentages chemosuppression/inhibition and higher effective doses/inhibitory IC50 compared to NU in both experiments respectively suggesting that the constituents were acting synergistically. The GC-MS analysis revealed a total of eleven compounds in MNU partitioned into HNU: Neophytadiene, Hexadecanoic acid methyl ester, N--Hexadecanoic acid, 10 octa decenoic acid methyl ester and Methyl stearate, DNU: 2 ethyl acridine, ENU: Benzoic acid methyl ester and ANU: Benzoic acid methyl ester, 2 ethyl acridine while additional five compounds found in MNU were not detected in any of the fractions.
Conclusion: The constituents of the antimalarial MNU seem to be acting synergistically to inhibit haemozoin formation in the parasite.
PERFORMANSI ALAT PENGASAPAN IKAN DENGAN SISTEM ROTARI HORIZONTAL
Authors: Perdana Mastariyanto , Hafni Hafni , Yulianti Lusi , Romi Romi , Alfith Alfith , Pratiwi Putri , Nurzal Nurzal 
Published: December 2024

Salah satu teknik pengawetan ikan yang sangat banyak dimanfaatkan pada saat ini adalah teknik pengasapan. Pada umumnya proses pengasapan ikan masih secara tradisional dan menggunakan oven konvensional. Metode tersebut merupakan cara yang mudah untuk melakukan pengasapan ikan. Tujuan penelitian ini adalah untuk mengetahui efisiensi alat pengasapan ikan dengan menggunakan sistem rotari horizontal. Alat pengasapan ikan ini terdiri dari ruang pengasapan, tungku pembakaran, dudukan lele sistem rotari, motor DC, roda gigi, dan rantai. Kapasitas alat pengasapan ikan system rotari ini adalah 9 kg ikan basah. Ikan yang digunakan pada penelitian ini adalah ikan lele dan ikan cakalang. Pengasapan ini menggunakan hasil dari pembakaran kayu kulit manis. Kayu kulit manis akan menghasilkan asap yang berguna untuk pengasapan ikan. Berat ikan basah dalam satu kali pengasapan pada penelitian ini adalah 8 Kg. Metode pengasapan mempunyai standar perbandingan berat ikan basah dan berat ikan kering sebesar 4:1. Untuk pengasapan ikan lele, setelah dilakukan pengasapan selama 2 jam dengan temperatur 80 oC – 90 oC, berat ikan lele menjadi 2 kg. Untuk pengasapan ikan cakalang, setelah dilakukan pengasapan selama 2,5 jam dengan temperatur 80 oC – 90 oC, berat ikan cakalang menjadi 2 kg. Dari hasil pengujian, dapat disimpulkan bahwa alat pengasapan ikan dengan sistem rotari sangat bagus untuk digunakan sebagai alat pengasapan ikan karena memiliki efisiensi yang cukup tinggi dibandingkan dengan alat tradisional seperti oven dimana metode pengasapan tradisional membutuhkan waktu selama 36 jam dan metode pengasapan sistem oven membutuhkan waktu selama 12 jam.
PENGGUNAAN PASIR SILIKA SEBAGAI BAHAN PEMBUATAN PAVING BLOCK
Authors: Mulyati Mulyati , Fakhri Jovari Ibrahim 
Published: December 2024

Penelitian ini menggunakan pasir silika sebagai bahan pembuatan paving block. Tujuan dari penelitian ini adalah untuk mengetahui nilai kuat tekan dan penyerapan air paving block dari penggunaan pasir silika sebagai bahan pengganti sebagian pasir dalam pembuatan paving block. Bahan campuran pembutan paving block digunakan perbandingan 1 bagian semen dan 3 bagian pasir, dengan variasi penggunaan pasir silika adalah 0%, 5%, 10%, 15%, dan 20%. Pembuatan benda uji paving block dilakukan secara manual dengan ukuran cetakan 21 cm x 10,5 cm x 6 cm. Pengujian kuat tekan dan penyerapan air paving block dilakukan pada umur 28 hari. Hasil penelitian pembuatan benda uji paving block dengan menggunakan pasir diperoleh kuat tekan rata-rata sebesar 8,81 MPa dan penyerapan air rata-rata sebesar 15%, dengan menggunakan pasir silika 5%, 10%, 15%, dan 20% diperoleh kuat tekan rata-rata berturut-turut sebesar 9,56 MPa, 11 MPa, 13,5 MPa, 14,94 MPa, dan penyerapan air rata-rata berturut-turut sebesar 13%, 10,1%, 9,5%, 9,2%. Dengan demikian penggunaan pasir silika sebagai pengganti pasir dalam pembuatan paving block dapat meningkatkan kuat tekan dan menurunkan penyerapan air paving block.
WITHDRAWN: Parametric Optimization of Friction Stir Welding Factors (FSWF) for Yellow Brass 405-20
Authors: Raza Syed Farhan , Khan Sarmad Ali , Habib Muhammad Salman , Ahmed Naveed , Ishfaq Kashif , Mehdi Ahmed 
Published: December 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: An Evaluation of Optimal Friction Stir Welding Factors (FSWF) For Yellow Brass 405-20
Authors: Raza Syed Farhan , Khan Sarmad Ali , Habib Muhammad Salman , Ahmed Naveed , Ishfaq Kashif , Mehdi Ahmed 
Published: December 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: Development of a Novel Hybrid Salp Swarm-Kepler Algorithm for Engineering Problems: Optimizing Microgrid Sizing with Integration of Photovoltaic, Wind, Battery, and Supercapacitor Systems
Authors: Güven Aykut Fatih 
Published: December 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Characterization of the soybean ABF gene family and the key regulatory function of GmABF1 in salt stress response
Authors: Zhang Bin-shuo , Li Mingyang , Song Zhen , Han Jing-pei , Cheng Zi-qian , Chen Xiang-jin , Han De-zhi , Hu Zhen-bang , Liu Chun-yan , Yang Ming-liang , Qiu Li-juan , Wu Xiao-xia , Zhao Ying 
Published: December 2024

Abstract

The abscisic acid (ABA) response signal pathway depends heavily on ABRE binding factors (ABF), a distinctive subfamily of basic leucine zipper (bZIP) transcription factors in plants. The objective of this study was to conduct a comprehensive analysis of the soybean (Glycine max (L.) Merr.) ABF gene family across the entire genome and to understand the function and regulatory mechanisms of the GmABF1 gene in response to salt stress. A total of 20 ABF genes were identified in the soybean genome. Different soybean tissues, including roots, stems, leaves, flowers, pods, and seeds, all exhibited significant differences in the expression of GmABFs genes, indicating distinct tissue-specific patterns. The GmABFs family is located within the nucleus of the cell. According to the replication events in soybeans, the GmABF gene underwent tandem replication and fragment duplication. The promoter analysis revealed that the GmABF genes play a role in soybean growth, development, and stress response. Moreover, the GmABF genes were observed to be controlled by several stressors, such as salinity, alkaline, drought, and osmotic stress. GmABF1 was identified as an important regulator of soybean salt stress tolerance. GmABF1 overexpression effectively protected against ROS accumulation, thereby enhancing salt stress tolerance. Three polymorphic sites associated with salt tolerance were found in the promoter region of the GmABF1 gene. It was determined that the variation in the promoter region of the GmABF1 gene was closely associated with the salt tolerance of soybeans. These findings provide new insight into the biological functions ABF family members perform in plant stress responses, serving as a significant basis for developing soybean varieties with enhanced stress tolerance.
Spatial Control of Curing Kinetics in Thiol-Ene-Systems through
Antagonistic Photoreactions
Authors: Griesser Thomas , Höller Rita Johanna , Sivun Dmitry , Müller Stefanie Monika , Jacak Jaroslaw , Schlögl Sandra 
Published: December 2024

Abstract

The use of two wavelengths to activate different photoreactions in a resin system has recently attracted much attention in the scientific community. Here, wavelength orthogonal photochemistry was used to spatially control the curing kinetics of the thiol-ene photopolymerization reaction. In the investigated resin system, radical curing is activated by a type II photoinitiator at 450 nm, while light at 365 nm is used to photorelease a base, resulting in an inhibition of the curing reaction. The antagonistic nature of these photoreactions is demonstrated in laser writing and grey scale patterning experiments. The controlled inhibition and retardation of the thiol-ene curing reaction in a spatial manner paves the way for numerous applications in 3D printing or sub-µm photolithography.
Exploring the bacteriome use as a proxy for climate change and pollution impacts on groundwater in temperate and tropical countries
Authors: Moldovan Oana Teodora , Levei Erika , Ferreira Rodrigo Lopes , Silva Marconi Souza , Mirea Ionuț Cornel 
Published: December 2024

Abstract

This research investigates bacterial communities in various cave pool water and substrates from Brazil and Romania for their use as indicators of environmental impacts on groundwater. Significant regional and seasonal differences were observed even if, at the phylum level, common bacteria were found in both countries. Distinct patterns emerged at the genus level due to the different climates (tropical vs. temperate) and ecosystems. Chemoautotrophic conditions define a completely different groundwater bacteriome than oligotrophic conditions independent of the temperature. Bacteria as a proxy for climate change were explored using seasonal changes; specific genera become dominant in summer months, such as Acinetobacter, Paeniglutamicibacter, Polaromonas, and Saccharimonadales, indicating processes that occur during the low-water season. Climate change, particularly dryness, is expected to exacerbate these variations, threatening the stability of groundwater ecosystems. The research also identified pollution indicators (Vogesella, Cutibacterium) and potential decontaminants (Bacillus) in Brazilian cave waters. Pollution indicators, like Pseudoarthrobacter. were also found in Romanian caves. Other key bacteria genera, such as Flavobacterium, Pseudomonas, and Acinetobacter, are chemolithotrophs or involved in the nitrogen cycle with a critical role in supplying nutrients for the cave food web were found in the Romanian samples. Marked differences between water and substrate microbiomes within the same pools suggested that substrates may play a crucial, underexplored role in groundwater ecosystem processes. Our study found unassigned taxa, 3 phyla, 2 families, and 832 genera (> 40%), in the studied pools. The results underscore the need to further explore groundwater microbiomes as potentially crucial yet fragile ecosystems in the face of climate change and human impacts.
Performance Evaluation in a Smart Work Environment: Process versus Outcome-Centric Employee Evaluations Based on Psychological Distance
Authors: Seo Bong-Goon , Park Do-Hyung 
Published: December 2024

Abstract

The rapid development of IT technology and social changes has given rise to a new work modality known as Smart Work. This study explores how the psychological distance between evaluators and those evaluated in a Smart Work environment influences assessments, centering around Construal Level Theory. The findings reveal that Smart Work increases the psychological distance for evaluators, thereby elevating their level of construal and leading to outcome-focused thinking. In contrast, traditional work methods keep psychological distance relatively closer, fostering process-oriented thinking. This research highlights the crucial role of psychological distance in shaping evaluation strategies in workplaces and offers valuable insights for organizations aiming to effectively integrate Smart Work practices. This exploration not only contributes to our understanding of Smart Work's organizational and psychological dynamics but also suggests implications for performance management systems in contemporary work environments.
Conversion to dementia in very late-onset schizophrenia-like psychosis classified with Alzheimer's disease and Lewy body disease biomarkers: A retrospective cohort study
Authors: Satake Yuto , Kanemoto Hideki , Taomoto Daiki , Takeda Kayo , Katakami Shigeki , Kobayashi Matasaburo , Matsunaga Keiko , Isohashi Kayako , Suehiro Takashi , Yoshiyama Kenji , Ikeda Manabu 
Published: December 2024

Abstract

This study aimed to examine the conversion rate to dementia and cognitive changes in individuals with very late-onset schizophrenia-like psychosis (VLOSLP) classified with Alzheimer's disease (AD) and Lewy body disease (LBD) biomarkers. Patients with VLOSLP were retrospectively enrolled in the study, and follow-up assessments were conducted at least once up to approximately 2 years. Participants were classified into AD and LBD biomarker-negative (BMs-neg), AD-biomarker-positive and LBD biomarker-negative (AD-pos/LBD-neg), and LBD biomarker-positive (LBD-pos) groups. The conversion rate during the study period and longitudinal cognitive changes between the initial and final assessments were analyzed. Nineteen participants were enrolled in the study among patients who visited the neuropsychology clinic of the Department of Psychiatry, Osaka University Hospital, for the first time between 2018 and 2023. The conversion rates to dementia were 14%, 67%, and 50% in the BMs-neg, AD-pos/LBD-neg, and LBD-pos groups, respectively, without a significant difference (p = 0.187). At the follow-up assessment, all four participants who experienced conversion in the AD-pos/LBD-neg group were diagnosed with AD dementia, while in the LBD-pos group, two of such patients were diagnosed with dementia with Lewy bodies, and one was diagnosed with idiopathic normal pressure hydrocephalus. The only participant in the BMs-neg group converted was diagnosed with an unclassified form of dementia. Mixed-design analysis of variance revealed a significant group-by-time interaction in the Clinical Dementia Rating sum of boxes (p = 0.004). Patients with VLOSLP who are positive for AD and/or LBD biomarkers may be more likely to progress to dementia within 2 years than those who are negative.
Tannic Acid-Zinc Crosslinked Chitosan Hydrogels: High-Performance adsorbent for Titan Yellow removal from wastewater
Authors: Gupta Harshit , Singh Nahar 
Published: December 2024

Abstract

The capability to engineer hybrid materials with specific properties drives innovation across multiple technological fields. A straightforward wet chemical procedure was initially used to make chitosan zinc hydrogel (ChZn) to remove titan yellow (TY) dye from water to use hybrid material for water purification. The maximal adsorbent dose of 22.1 mg for 10.0 mL of 500 mg L-1 TY showed a removal capacity of 384.45 mg g-1 at optimum pH and a contact time of 25 minutes. To improve the adsorption capacity of ChZn, it was crosslinked with tannic acid (TA). Remarkably, under optimized parameters, TA-zinc crosslinked chitosan hydrogels (ChZnTA) exhibited a removal capacity of 505.05 mg g-1. The adsorption process adheres to Pseudo-second order kinetics and aligns with the Freundlich isotherm. The ChZnTA interaction with TY dyes indicated interactions resulting from hydrogen bonding, π-π stacking, van der Waals, and electrostatic forces. Furthermore, desorption-regeneration studies demonstrate that even after being used for up to three cycles, ChZnTA and ChZn effectively eliminate TY up to 79.9% and 53.8%, respectively.
Exploration of Potential Therapeutic Targets of Diosgenin in Pulmonary Fibrosis through Network Pharmacology and Mendelian Randomization
Authors: 徐 文颉 , 黄 文 , 辛 光 , 潘 文希 
Published: December 2024

Abstract

Background:
Pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF), is a chronic, progressive lung disease with limited therapeutic options. Diosgenin, a steroidal sapogenin, has been suggested to have potential therapeutic effects on various diseases. This study aims to identify and validate potential protein targets of diosgenin in pulmonary fibrosis using comprehensive bioinformatics analysis and Mendelian randomization.
Methods:
The potential targets of diosgenin were initially identified through SwissTargetPrediction and Super-PRED databases, resulting in 234 predicted protein targets. Pathway analysis and the construction of a protein-protein interaction (PPI) network were performed to elucidate the functional pathways of these targets. Subsequently, we intersected these targets with genes associated with pulmonary fibrosis to identify core targets. Mendelian randomization (MR) for pulmonary fibrosis and idiopathic pulmonary fibrosis was conducted using five different MR methods.
Results:
14 core targets were fetched through our analysis, including STAT3, BRAF, CFTR, DPP9, ICAM1, IL2, MMP1, NFKB1, NOS2, NOS3, PDGFRA, SERPINE1, SRC, and TLR4. Among the 14 core targets, Intercellular Adhesion Molecule 1 (ICAM1) and Nuclear Factor Kappa B Subunit 1 (NFKB1) both showed significant associations with postinflammatory pulmonary fibrosis. Specifically, ICAM1 was associated with an increased risk of postinflammatory pulmonary fibrosis (OR [95% CI] = 2.07 [1.16–3.68], P = 0.014), while NFKB1 was similarly associated with an increased risk (OR [95% CI] = 2.25 [1.13–4.49], P = 0.022). These findings indicate potential causal relationships between these genes and the development of postinflammatory pulmonary fibrosis.
Conclusion:
This study identifies Intercellular Adhesion Molecule 1 (ICAM1) and Nuclear Factor Kappa B Subunit 1 (NFKB1) as significant genetic associations with postinflammatory pulmonary fibrosis, suggesting their potential roles as therapeutic targets. The findings indicate that both ICAM1 and NFKB1 may contribute to the pathogenesis of postinflammatory pulmonary fibrosis, providing a foundation for further experimental validation and therapeutic exploration aimed at these targets.
Protective efficacy of pDNA vaccine Candidates against lethal SARS-CoV-2 in Syrian Golden Hamsters
Authors: Alzamil Iman Almansour , Golovan Serguei , Pickens Jennifer , Salley Krista , Roberts Michael 
Published: December 2024

Abstract

Seasonal Covid-19 vaccination is known as an efficient way to control Covid-19 pandemic. Despite these efforts, the currently approved mRNA and protein vaccines had been associated with risks of myocarditis and pericarditis. In addition, PEGylated nanoparticles have been associated with elevated risk of developing allergic reaction in people with high risk. To enhance safety of Covid-19 vaccines, alternative platform that can overcome this limitation are needed. Here, we developed pDNA based Covid-19 vaccine candidate administered by needle immunization. We assessed the immunogenicity of the vaccine candidate which predominantly produced high titer IgG2. In addition, the protective efficacy was evaluated. We determine that Th1 skewed immune response was important in conferring protection upon lethal virus challenge. These data shed new light on the importance of IgG isotype for the development of Covid-19 vaccine candidate. Furthermore, our finding is applicable for further testing on several vaccine candidates against other pathogens.
Effects of cognitive behavioral therapy for misophonia: A systematic review
Authors: Kazemi Mahmoud , Javdani Negin , shahmoradpour Eilnaz , Alizadehgoradel Jaber 
Published: December 2024

Abstract

Abstract
Background: Misophonia is a condition characterized by intense physical and emotional reactions to everyday sounds, commonly known as triggers. Despite its prevalence, with estimates suggesting that 6% to 20% of students are affected, research on effective treatments remains limited. Misophonia is believed to stem from enhanced connectivity between the limbic system and auditory structures, rather than auditory abnormalities. Comorbidities with mental disorders such as PTSD, OCD, and major depressive disorder are common. While no definitive treatment has been established, cognitive behavioral therapy (CBT) shows promise. Studies indicate that CBT can reduce distress and improve coping strategies, with significant symptom improvement reported after CBT interventions.
Methods: We included randomized controlled trials, open-label studies, and pilot cases focused on misophonia, using PubMed, PsycINFO, Web of Science, and Google Scholar for our search. Non-English studies, animal research, and case reports were excluded. Data extraction covered study parameters and outcomes, and biases were evaluated using the Cochrane Collaboration method.
Results: Screening 28 studies led to inclusion of six, including randomized controlled trials and an open-label study. Results show cognitive behavioral therapy (CBT) significantly reduces misophonia symptoms, with studies reporting up to 48% improvement in A-MISO-S scores and sustained benefits over time. These findings underscore CBT’s potential as a promising treatment for misophonia, though further research is needed to establish standardized protocols and long-term efficacy.
Conclusion: This systematic review confirms CBT as effective for treating misophonia, highlighting its symptom reduction and quality of life improvements. Further research is needed to refine CBT protocols and explore alternative treatments.
The Effect of Nifedipine on the Pharmacokinetics of Imatinib and its Metabolism N-desmethyl Imatinib in Rats
Authors: Fan Naling , Du Liying , Guo Teng , Liu Mingfeng , Chen Xinran 
Published: December 2024

Objective:
Imatinib is a first-line medicine for chronic myeloid leukemia (CML) and
gastrointestinal mesenchymal stromal tumors (GIST). Co-administration of nifedipine may lead to
drug-drug interactions that affect the clinical efficacy of imatinib. Imatinib and nifedipine are substrates
for the cytochrome enzyme CYP3A4. This study aimed to research the pharmacokinetic effect
of nifedipine on imatinib and its metabolism N-desmethyl imatinib in rats.

Methods:
Twenty healthy SD rats were randomly divided into two groups. The control group was
administered imatinib by gavage for 14 days, and the experimental group was co-administered
imatinib and nifedipine by gavage for 14 days. The plasma concentrations of imatinib and N-desmethyl
imatinib in rats were determined by ultra-performance liquid chromatography-mass spectrometry.

Results:
The MRT0-∞ and Tmax of imatinib in the experimental group differed significantly from the
control group after a single dose (P < 0.05, 95% CI). Tmax and t1/2z of imatinib and AUC0-∞ and Tmax
of N-desmethyl imatinib were also obviously different between the two groups after multiple doses
(P < 0.05, 95% CI).

Conclusion:
The study showed that nifedipine might inhibit the imatinib metabolism after single--
dose administration, but nifedipine did not significantly impact imatinib metabolism after multiple-
dose administration.