bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Cooperative Integrated Reading and Composition (CIRC) Learning Model Based on Local Wisdom to Improve Reading Skills in Children
Authors: Ghofur Abdul , Widiastuti Rini , Hayati Noorfah , Doorvina Doorvina , Sukini Sukini , Dewanto Dewanto 
Published: January 2025

This study aims to determine the effectiveness of the cooperative Integrated Reading and Composition (CIRS) learning model based on local wisdom in improving reading skills in children. This research is a type of meta-analysis research. Research data was obtained from 22 studies that met the inclusion criteria. Data was obtained from Google Scholar, ERIC, ScienceDirect, Wiley, and IEEE databases. Data analysis calculates the effect size value with the help of JASP software. The results of the study concluded that the value of the summary effect size was d = 1.010. These findings show that the cooperative Integrated Reading and Composition (CIRS) learning model based on local wisdom significantly affects reading ability in children with a very high influence category. In addition, this research is expected to contribute to future educational and research practices.
Czasownik leksykalny, łącznikowy, posiłkowy – badanie korpusowe statusu składniowego czasownika blîven (‘(po)zostać’) w tekstach średnio-dolno-niemieckich
Authors: Woźnicka Marta 
Published: January 2025

W ramach tekstu przedstawiono wyniki analizy składniowo-semantycznej średnio-dolno-niemieckiego czasownika blîven, który został zapożyczony do języków nordyckich i którego semantyka oraz status składniowy zarówno w języku wyjściowym, jak i w językach docelowych są sporne. Badanie obejmuje szerszy niż dotychczas materiał językowy z okresu między XIII a XV w., a stanowią go teksty dostępne w ramach anotowanego korpusu Referenzkorpus Mittelniederdeutsch/Niederrheinisch (ReN) i teksty korpusu Diachrony of passive voice in North Germanic (DiaPass). Zawężenie czasowe badanych tekstów pozwoliło stwierdzić, że rozwoju peryfrastycznej strony biernej w języku szwedzkim z bli(va) nie można przypisać wpływom dolnoniemieckim. Tenże wniosek potwierdza sporadyczne użycie blîven w połączeniu z imiesłowem biernym w materiale dolnoniemieckim z równoczesnym wzrostem ogólnej częstotliwości występowania tej konstrukcji w języku szwedzkim w XV w. Wykorzystanie obu korpusów pozwoliło wykluczyć różnice w użyciu czasownika blîven między tekstami dolnoniemieckimi spisanymi na obszarze dolnoniemieckim (ReN) a tekstami dolnoniemieckimi z obszaru skandynawskiego (DiaPass).
ТЕОРЕТИЧНІ ТА ПРАКТИЧНІ АСПЕКТИ ФОРМУВАННЯ СТРАТЕГІЇ РОЗВИТКУ HR-БРЕНДУ ІТ-ГАЛУЗІ
Authors: ПЕНЮК Валерія 
Published: January 2025

The article is devoted to the study of theoretical and practical aspects of the development strategy of the HR brand in the IT industry. It is substantiated that the creation of an attractive HR brand is a guarantee of the effective development of the activities of many IT companies. It was determined that although HR-branding is a driver in the labor market, in the current conditions of Ukraine, the employer's brand is insufficiently researched in scientific circles. It is determined what characterizes the need for the formation of an HR brand under the conditions, if the company has a development plan and future prospects, plans to enter new markets and open offices abroad, or seeks to maintain the efficiency and productivity of the existing team. It has been proven why the main objects of influence of the company's internal HR brand are employees, and the external one - people who are looking for a job.
The internal and external objects of the HR brand are characterized. The author's interpretation of the HR brand of the IT industry is given, where it is determined that the HR brand from the position of the company-employer is a set of meaningful (what the organization offers to its current or potential employee) and communicative characteristics (the form in which it does this).
HR brands were analyzed, in particular IT companies with positive dynamics in terms of the number of specialists and the best IT companies to work for. The list of criteria for choosing an employer in the IT industry is given, as well as the rating of the best IT companies according to the choice of IT specialists. It was determined that the HR brand strategy should include work on the internal brand and promotion of the external brand. The influence of the war on the work of companies and the relationship to the formation of the HR brand is substantiated, and it is explained why some enterprises entered new regions of their own free will or at the request of customers. The conclusion includes measures to preserve the positive image of the company and form an effective strategy for the development of the HR brand in the IT industry.
Plate Buckling Assessment of Unstiffened and Uniaxial Compressed Plates through Overall Imperfection Method
Authors: Alewe Mohammad Kheer 
Published: January 2025

The Overall Imperfection Method (OIM) is a more comprehensive version of the Unique Global and Local Imperfection Method introduced for steel column design in EN 1993-1-1 standard. The generalized OIM is used to evaluate the stability resistance of steel members subjected to irregular load conditions. This study extensively examines the Overall Imperfection Method (OIM) used in analyzing plate buckling, explicitly focusing on steel grades such as S235, S355 and S460. It compares OIM with methods mentioned in EN 1993-1-5 (Annex B, GMNIA and winter curve). The research carefully validates OIM by analyzing Equation (13) (Annex B) across ratios and studying its behavior with various steel grades. The study highlights the importance of finding a balance when applying OIM regarding material properties and slenderness ratios. These findings provide insights for engineering professionals. Additionally, the research introduces a calibrated equation that allows for the application of OIM without exceeding the limits set by GMNIA. This simplifies its implementation in engineering practice.
PENGARUH ELECTRONIC WORD OF MOUTH TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN NORU COFFEE DI BUKITTINGGI
Authors: Putra Rahmad Yunendri , Heikal Jerry , Ningsih Andria , Amelia Dona 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui faktor-faktor pembentuk eWOM dan pengaruhnya terhadap Keputusan Pembelian pada Noru Coffe. Penelitian ini merupakan penelitian eskplanatori kuantitatif dengan menerapkan Analisis Binary Logistik. Dalam penelitian ini terdapat sampel sejumlah 100 orang dengan kriteria masyarakat umum yang sudah melakukan pembelian pada Noru Coffee. Setelah menerima informasi mengenai Noru Coffee melalui electronic word-of-mouth (eWOM) yang tersebar pada situs jejaring sosial Instagram. Hasil penelitian ini menunjukkan bahwa ada 3 buah faktorÂ yakni: Faktor Expressing Positive Feelings, Faktor Platform Assistance, dan Faktor Concern For The Others. Dari ketiga faktor tersebut hanya faktor Platform Assistance memiliki pengaruh yang positif dan signifikan terhadap Keputusan Pembelian, dan Faktor Paltform Assistance yang berpengaruh dominan terhadap Keputusan Pembelian.
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Biomolecule screen identifies several inhibitors of Salmonella enterica surface colonization
Authors: Headrick Joseph , Ohayon Amital , Elliott Shannon , Schultz Jacob , Mills Erez , Petersen Erik 
Published: January 2025

Salmonella enterica is a foodborne pathogen commonly found in agricultural facilities; its prevalence, as well as increasing levels of disinfectant- and antibiotic-resistance, has significant costs for agriculture as well as human health. In an effort to identify potential new inhibitors of S. enterica on abiotic surfaces, we developed a biomolecule screen of nutrient-type compounds because nutrients would have lower toxicity in animal facilities and bacterial nutrient utilization pathways might prove less susceptible to the development of bacterial resistance. After screening 285 nutrient-type compounds, we identified ten that significantly inhibited the ability of S. enterica to colonize a plastic surface. After conducting a dose-response curve, salicylic acid was selected for further testing due to its low minimal inhibitory concentration (62.5 μM) as well as a low total inhibitory concentration (250 μM). Salicylic acid was also able to inhibit surface colonization of a wide range of bacterial pathogens, suggesting that our biomolecule screen might have broader application beyond S. enterica. Finally, we determined that salicylic acid was also able to inhibit S. enterica colonization of an organic surface on eggshells. Together, these results suggest that nutrient-type biomolecules may provide an avenue for preventing resistant bacteria from contaminating surfaces.
β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion
Authors: Zhang Ru , Wang Weijia , Li Aitian , Wang Huishang , Liu Xiaoyan , Fan Feifei , Wang Ying , Zhang Huanyu , Chang Jingxia , Zhang Yinyin , Wang Hongmin , Miao Lijun , Huang Bo , Yang Li , Zhang Yi 
Published: January 2025

IntroductionMalignant pleural effusion (MPE) is associated with poor quality of life and mortality in patients with tumors. In clinical practice, we observed that patients with malignant pleural effusion (MPE) and concurrent heart disease exhibited a decrease in MPE volumes following treatment with β-receptor blockers for heart disease. Immunosuppressive tumor microenvironment was found to play a substantial role in the progression of MPE, and mainly attributed to tumor-associated macrophages (TAMs). However, whether β-receptor blockers improve MPE through affecting the immune microenvironment especially TAMs and the potential mechanism behind remains unclear.MethodsIn this study, we collected the MPE samples from MPE and heart disease patients treated with propranolol, and performed flow cytometry experiment to evaluate the effect of propranolol on MPE immune microenvironment. Then, the mechanism that how propranolol effectively reprogrammed the immunosuppressive microenvironment of MPE was conducted by the experiments of mass spectrometry, RNA-seq, flow cytometry, immunofluorescence, western blotting, etc. Lastly, to further evaluate the effect of propranolol on MPE therapy in vivo, we developed a mouse model of MPE. We administrated propranolol into MPE-bearing mice to investigate the therapy efficacy and the changes of MPE microenvironment by the experiments of computed tomography (CT) scanning, flow cytometry, etc.ResultsWe observed that propranolol treatment in MPE patients with heart disease decreased TAM frequency and immunosuppression and enhanced anti-tumor immunity. Macrophages in MPE exhibited an immunosuppressive phenotype via the activation of norepinephrine metabolism. Subsequently, we found that lactate was increased in MPE and may contribute to an increase in TAM frequency and inhibition of anti-tumor immunity by macrophages. Additionally, lactate triggered phenylalanine/norepinephrine signaling and further induced macrophage immunosuppression in an ERK-depended way. Lastly, in the MPE mouse model, propranolol inhibited MPE development and reversed the immune microenvironment of MPE.DiscussionHere, we reveal the mechanism by which lactate induces macrophage immunosuppression via activating phenylalanine/norepinephrine signaling. Our findings highlight that blocking norepinephrine signaling by β-receptor blockers is an attractive therapeutic strategy to enhance anti-tumor immunity in the context of MPE
Analysis of the role of acetylation in Giardia lamblia and the giardicidal potential of garcinol
Authors: Patolsky Rocío G. , Laiolo Jerónimo , Díaz-Pérez Luciano , Luna Pizarro Gabriel , Mayol Gonzalo F. , Touz María C. , Feliziani Constanza , Rópolo Andrea S. 
Published: January 2025

IntroductionPost-translational modifications of proteins provide cellular physiology with a broad range of adaptability to the external environment flexibly and rapidly. In the case of the protozoan parasite Giardia lamblia, the study of these modifications has gained relevance in recent years, mainly focusing on methylation and deacetylation of proteins. This study investigates the significance of acetylation in this protozoan parasite.MethodsThis study explores the role of acetylation in G. lamblia through a combination of immunofluorescence assays, manipulation of acetyltransferase enzymes, and the use of garcinol, an acetylation inhibitor, during the growth phase.ResultsThe acetylation of histone marks H3K9 and H3K27 occurs during growth and is followed by deacetylation during encystation. Transfections modifying acetyltransferase activity induced a latent cellular state, underscoring the importance of protein acetylation for parasite survival. Garcinol treatment during growth caused significant morphological changes, including plasma membrane blebbing and apoptotic-like bodies. Immunofluorescence revealed these bodies contained α-tubulin/acetylated α-tubulin and reactive oxygen species. Flow cytometry and Annexin V staining indicated early apoptosis within 24 hours of treatment. Additionally, garcinol led to the deacetylation of H3K9 and H3K27, with redistribution of tubulin and acetylated tubulin from microtubules to the cytosol. Significantly, garcinol prevented parasite recrudescence after treatment withdrawal.DiscussionThese results demonstrate that acetylation is essential for trophozoite survival and highlight the natural histone acetyltransferase inhibitor garcinol as a potential candidate for drug development against giardiasis, considering its giardicidal activity.
Attitudes toward healthy nutrition in Germany — results from an online-representative cross-sectional survey
Authors: Hanslian Etienne , Schiele Julia Katharina , Jeitler Michael , Michalsen Andreas , Wischnewsky Manfred , Storz Maximilian Andreas , Brinkhaus Benno , Ortiz Miriam , Sigl Mike R. , Hoffmann Rasmus , Lehmann Judith , Koppold Daniela A. , Keßler Christian S. 
Published: January 2025

IntroductionNutrition plays a crucial role in current German public health strategies. While sociodemographic differences in nutrition have been extensively studied, recent data specific to Germany remains limited.MethodsAn online-representative cross-sectional survey was conducted in 2022 among German-speaking adults aged 18–75 using a Computer Assisted Web Interview (CAWI) format. The survey addressed personal eating habits, the importance of nutrition, motivations behind food choices, and openness to dietary changes. Data analysis included both descriptive and inferential statistics, incorporating CHAID decision tree analysis and nonparametric methods for inductive statistical evaluation.ResultsAmong the 4,065 participants, 62.3% regarded healthy nutrition as important, with women, individuals with higher education, and those aged under 26 or over 70 demonstrating greater emphasis on nutrition. CHAID analysis identified education as the most significant predictor of attitudes toward healthy nutrition, followed by sex and income. Participants with a positive attitude toward healthy nutrition reported higher HRQoL scores (EQ-Index = 0.862) compared to neutral or negative attitudes (EQ-Index = 0.835)0.10.5% of participants reported not to eat meat, 28.6% were self-reported flexitarians and 54.1% of participants considered themselves omnivorous. Gender-specific dietary preferences were observed, with plant-based diets being much more popular among females. Participants identified taste preference as the primary factor influencing food choices (77.2%) when asked about the main reasons for their eating habits. Approximately 18% of participants predominantly or exclusively bought organic foods. Interestingly, one third of participants indicated a willingness to adopt a more plant-based diet if recommended by physicians or scientists.ConclusionThis online representative survey revealed significant associations between nutrition and sociodemographic aspects. Understanding this complex interplay might be useful for public health nutrition strategies that promote healthier national eating patterns.
Exogenous ALA applied on different plant parts promotes tomato fruit quality and GABA synthesis
Authors: Bai Peng , Wang Junwen , He Yongmei , Feng Junfang , Li Juanli , Shang Xingpan , Wu Yue , Yu Jihua , Tang Zhongqi , Xie Jianming 
Published: January 2025

IntroductionTomato fruit are rich in γ-aminobutyric acid (GABA), which lowers blood pressure and improves sleep. An increase in GABA content is important for enhancing the nutritional quality of tomato fruit.MethodsTo investigate the effects of 5-aminolevulinic acid (ALA) on fruit quality and GABA synthesis in greenhouse tomatoes, the tomato cultivar (Solanum lycopersicum cv. ‘184’) was used as an experimental material. During the fruit-setting period, root drenching with 0, 10, and 50 mg·L−1 ALA, foliar spraying with 0, 50, and 100 mg·L−1 ALA, and fruit surface spraying with 0, 100, and 200 mg·L−1 ALA were applied. The study investigated the application of exogenous ALA to different parts of the plant to determine the optimal ALA concentrations for each application site (10 mg·L−1 for root application, 100 mg·L−1 for foliar application, and 100 mg·L−1 for fruit surface application). Using the selected optimal ALA concentrations, tomatoes were used to study the effects of exogenous ALA application at different sites on fruit quality and GABA synthesis of greenhouse tomatoes.Results and discussionThe results demonstrated that exogenous ALA application to different parts of greenhouse-grown tomato plants substantially increased single-fruit weight by 42.37%–76.24%, soluble sugar content by 78.51%–94.52%, soluble solids by 9.09%–41.71%, soluble protein by 82.71%–241.05%, and ascorbic acid content by 1.31%–5.06% in mature tomatoes. And it reduced the organic acid content of the fruit by 12.81%–33.61%. Moreover, ALA applied at different parts of plants substantially enhanced the free amino acid content by 11.22%–16.50%, among them, umami amino acid content by 7.26%–20.13%. Besides, GABA content in mature tomato fruits was increased by 214.58%–433.32 across the different application parts. Exogenous ALA application at different sites regulates the activity of glutamate acid decarboxylase (GAD) and increases the content of glutamate for GABA synthesis pathway during tomato fruit development, thereby affecting the GABA content. In summary, exogenous ALA applied at different parts of tomato plants regulates the metabolism of amino acids and enhances the biosynthesis of GABA, which promotes the nutrient quality of the fruit.
Research hotspots and trends in lung cancer STAS: a bibliometric and visualization analysis
Authors: Peng Xiuhua , Bian Hupo , Zhao Hongxing , Jia Dan , Li Mei , Li Wenhui , Xu Pengliang 
Published: January 2025

PurposeThis study employed the R software bibliometrix and the visualization tools CiteSpace and VOSviewer to conduct a bibliometric analysis of literature on lung cancer spread through air spaces (STAS) published since 2015.MethodsOn September 1, 2024, a computer-based search was performed in the Web of Science (WOS) Core Collection dataset for literature on lung cancer STAS published between January 1, 2015, and August 31, 2024. VOSviewer was used to visually analyze countries, institutions, authors, co-cited authors, and keywords, while CiteSpace was utilized to analyze institutional centrality, references, keyword bursts, and co-citation literature. Descriptive analysis tables were created using Excel 2021.ResultsA total of 243 articles were included from the WOS, with a significant increase in annual publications observed since 2018. China, Kadota K, and Fudan University were leading countries, authors, and institutions by publication volume. The top three authors by co-citation count were Kadota K, Chen C, and Adusumilli PS. The journal with the highest publication volume was Lung Cancer, with the most influential journal among the top 10 being the Journal of Thoracic Oncology. The most frequently cited reference was “Lobectomy Is Associated with Better Outcomes than Sublobar Resection in Spread through Air Spaces (STAS)-Positive T1 Lung Adenocarcinoma: A Propensity Score-Matched Analysis.” Keyword clustering categorized the research into four main areas: pathological studies of lung cancer STAS, biological mechanisms, prognostic assessment, and imaging analysis. Current research hotspots include deep learning, lung squamous cell carcinoma, and air spaces STAS.ConclusionThe current research on lung cancer STAS primarily focuses on pathological studies, biological mechanisms, prognostic assessments, and preoperative imaging model predictions. This study’s findings provide new insights and directions for future research in this area.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, identifier 589442.
The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model
Authors: Xu Changjing , Zhu Junlong , Tu Kun , Tang Hui , Zhou Xinxin , Li Qiuyu , Chen Kun , Yang Xuping , Huang Yilan 
Published: January 2025

BackgroundCefoperazone/sulbactam (CPZ/SAM) is an important treatment option for infections caused by multidrug-resistant gram-negative bacteria. However, it is associated with an increased risk of coagulation disorders (CD) and causes severe bleeding in some instances. Early identification of risk factors and prediction of CD related to CPZ/SAM are crucial for prevention and treatment. This study aimed to explore the risk factors and developed a nomogram model for predicting the risk of coagulopathy in patients undergoing CPZ/SAM treatment.MethodsA total of 1719 patients who underwent CPZ/SAM in the Affiliated Hospital of Southwest Medical University from August 2018 to August 2022, were recruited as the training cohort. For validation, 1,059 patients treated with CPZ/SAM from September 2022 to August 2024 were enrolled. Patients were divided into the CD and the N-CD groups. The occurrence of CD was designated as the dependent variable. The univariate and multivariate logistic regression analysis was performed to identify the risk factors of CD. A nomogram model was constructed from the multivariate logistic regression analysis and internally validated for model discrimination and calibration. The performance of the nomogram was estimated using the concordance index (C-index) and calibration curve.ResultsThe multivariate logistic regression analysis resulted in the following independent risk factors for CD: baseline INR level (OR: 5.768, 95% CI: 0.484∼11.372, p = 0.036), nutritional risk (OR:2.711, 95%CI: 1.495∼4.125, p &lt; 0.001), comorbidity of digestive system (OR:1.287, 95%CI: 0.434∼2.215, p = 0.004), poor food intake (OR:1.261, 95%CI: 0.145∼2.473, p = 0.032), ALB level (OR: −0.132, 95%CI: −0.229∼-0.044, p = 0.005) and GFR&lt; 30 mL/min (OR: 1.925, 95%CI: 0.704∼3.337, p = 0.004). The internal validation confirmed the model’s good performance (C-index, 0.905 [95% CI: 0.864∼0.945]). The calibration plots in the nomogram model were of high quality. Validation further confirmed the reliability of the nomogram, with a C-index of 0.886 (95% CI: 0.832–0.940).ConclusionThe nomogram model facilitated accurate prediction of CD in patients undergoing CPZ/SAM. And this could potentially contribute to reducing the incidence of CPZ/SAM-associated CD and consequently improving patients’ outcomes.