bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KONSENTRASI RAGI DAN DEHIDRASI ZEOLIT TERHADAP PEMBUATAN BIOETANOL SINGKONG (MANIHOT UTILISSIMA)
Authors: Mujiarto Sigit , Priyanto Joko , Purnomo Sigit Joko 
Published: December 2024

Kebutuhan energi Indonesia saat ini sebagian besar masih bertumpu pada bahan bakar fosil, persediaan bahan bakar tersebut semakin berkurang seiring berjalannya waktu. Ketergantungan terhadap bahan bakar fosil ini menjadi masalah besar dan perlu solusi yang mendesak. Salah satu langkah yang perlu diambil adalah memanfaatkan bioetanol berbahan dasar singkong sebagai alternatif penggantinya. Indonesia sebagai salah satu negara penghasil singkong terbanyak didunia, masih belum bisa memanfaatan sumber daya tersebut sebagai salah satu energi terbarukan. Pada penelitian ini dilakukan pembuatan bioetanol dengan bahan baku singkong (Manihot Utilisima). Penelitian ini menggunakan metode eksperimen pengaruh konsentrasi ragi (1,5%, 2%, 2,5%) dan proses dehidrasi zeolite dalam pembuatan bioetanol singkong untuk mengetahui karakteristik bioetanol. Dari hasil penelitian didapatkan karakteristik bioetanol terbaik pada variasi ragi 2,5% dengan nilai kadar air sebesar 84%, nilai densitas sebesar 0,8136 g/ml, dan nilai Viskositas sebesar 0,07973 dPa.s. Hasil ini mempunyai nilai mirip bahan bakar pertalite namun kadar air dan densitasnya masih lebih tinggi. Diharapkan kedepannya menjadi database untuk penelitian bahan bakar bioethanol berikutnya. Indonesia's current energy needs are still largely based on fossil fuels, the supply of these fuels is decreasing over time. This dependence on fossil fuels is a big problem and needs an urgent solution. One step that needs to be taken is to use bioethanol made from cassava as an alternative. Indonesia, as one of the largest cassava producing countries in the world, is still unable to utilize this resource as a form of renewable energy. In this research, bioethanol was produced using cassava as raw material (Manihot Utilisima). This research uses experimental methods on the influence of yeast concentration (1.5%, 2%, 2.5%) and the zeolite dehydration process in making cassava bioethanol to determine the characteristics of bioethanol. From the research results, it was found that the best bioethanol characteristics were the 2.5% yeast variation with a water content value of 84%, a density value of 0.8136 g/ml, and a viscosity value of 0.07973 dPa.s. This result has a value similar to pertalite fuel but the water content and density are still higher. It is hoped that in the future it will become a database for further bioethanol fuel research.
PENGARUH PENAMBAHAN AIR SCOOP DAN PEMBERIAN VARIASI BAHAN BRAKE PAD TERHADAP PENURUNAN PANAS PADA SISTEM REM
Authors: Maksum David Maulana , Farida Nike Nur 
Published: December 2024

Air scoop merupakan komponen untuk mengalirkan udara ke bagian kaliper. Metode yang digunakan dalam penelitian ini yaitu dengan menambahkan kompenen air scoop dan melakukan penggantian bahan brake pad yaitu carbon. Pengujian dilakukan dengan memanaskan sistem rem dengan cara kendaraan melaju sambil direm sejauh 500 meter (mencari suhu tertinggi) selanjutnya melajukan kendaraan dengan kecepatan 60 km/jam sejauh 700 meter dan direm dengan menggunakan rem belakang sampai kendaraan berhenti (suhu setelah pendinginan). Hasil penelitian dari 4 pengujian adalah sebagai berikut: pengujian rem standart (tanpa air scoop dan menggunakan brake pad standart memiliki suhu tertinggi 116,2˚C dan suhu seletah pendinginan 102,8˚C. Pengujian tanpa air scoop menggunakan brake pad carbon memiliki suhu tertinggi 111,9˚C dan suhu setelah pendinginan 92,8˚C. Pengujian dengan air scoop dengan brake pad standart memiliki suhu tertunggi 117,9˚C dan suhu setelah pendinginan 100,5˚C. Pengujian air scoop dengan brake pad carbon memiliki suhu tertinggi 117,6˚C dan suhu setelah pendinginan 85,8˚C. sehinngga dapat disimpulkan bahwa penambahan air scoop dan menggunakan brake pad carbon memiliki nilai pendinginan yang paling baik pada sistem rem. The air scoop is a component to channel air to the caliper. The method used in this research is by adding an air scoop component and replacing the brake pad material, namely carbon. The test is carried out by heating the brake system by driving the vehicle while braking for 500 meters (looking for the highest temperature) then driving the vehicle at a speed of 60 km/hour for 700 meters and braking using the rear brake until the vehicle stops (temperature after cooling). The research results from 4 tests are as follows: standard brake testing (without air scoop and using a standard brake pad has the highest temperature of 116.2˚C and after cooling temperature is 102.8˚C. Testing without air scoop using a carbon brake pad has the highest temperature of 111.9˚C and the temperature after cooling was 92.8˚C. The air scoop test with a standard brake pad had the highest temperature of 117.9˚C and the temperature after cooling was 100.5˚C. So it can be concluded that adding an air scoop and using a carbon brake pad has the best cooling value in the brake system.
TEACHER’S STRATEGIES IN PERIOD AND POST PANDEMIC TEACHING OF EARLY CHILDHOOD MUSIC
Authors: Panjaitan Sarah , Safrina Rien , Budiawan Hery 
Published: December 2024

The purpose of this study is to find out the strategies applied by teachers in early childhood music learning during and after the pandemic. The research method used in this study is the Literature Review method with narrative analysis techniques systematic review. The data comes from the results of existing research and is obtained from google search engines, google scholar, semantic scholar, researchgate and sage journals and books on learning strategies. Place and Time the Research was held in South Jakarta, Jakarta from September 2022 to January 2023. Data Collection is carried out by taking 15 articles which are processed by simplifying, systematically modernizing data in order to answer problems in research, which is then analyzed by providing logical arguments. The Object of Research is the teacher's strategy. Data Analysis is carried out by making notes and giving color to each category and then summarizing, presenting, and drawing conclusions. The results of this study are the strategies used by teachers during the pandemic in teaching early childhood music, namely inquiry learning strategies, quantum learning strategies, and integrated art learning strategies through singing and moving activities or dancing to music and post-pandemic, namely expository learning strategies, cooperative learning strategies, integrated art learning strategies, and active learning strategies through singing and playing music activities.
Synergizing high-quality tourism development and digital economy: a coupling coordination analysis in Chinese prefecture-level cities
Authors: Luo Yuyan , Wang Yue , Pan Ziqi , Li Huilin , Yang Ziwei , Lai Bin 
Published: December 2024

Abstract

With the rapid development of digital economy(DE), it provides a new driving force for high-quality tourism development(HQTD). How to coordinate HQTD and DE is a urgent issue to be resolved. In this study, the coupling coordination degree(CCD) between HQTD and DE in Chinese prefecture-level cities was analyzed using CCD model, and the factors driving of CCD were identified using random forest. The results show that (1) Chinese city-level HQTD and DE show a rising trend from 2010 to 2019, and coastal areas have higher levels compared to central and western. (2) CCD is in bare balanced in most cities, and only Shanghai, is in superior balanced, and there is spatial heterogeneity in CCD distribution, with the central region being lower, and other regions show a trend of spreading from the core city to the surrounding areas, in addition, HQTD always lags behind DE. (3) Consumption level and tertiary industry support are the key drivers of CCD, and the driving effect is more obvious in the eastern, northern and southern, while for the southwestern and northwestern, it’s mainly dominated by the economic development level. Based on these conclusions, some policy implications are provided for the synergistic development of HQTD and DE.
Forecasting the spatiotemporal evolution of fluid-induced microearthquakes with deep learning
Authors: Hu Meng-Su , Chung Jaehong , Manga Michael , Kneafsey Timothy , Mukerji Tapan 
Published: December 2024

Abstract

Microearthquakes (MEQs) produced by subsurface fluid injection record the spatial and temporal evolution of stress and permeability. Hence, the ability to forecast the spatiotemporal evolution of fluid-induced microseimicity is crucial for guiding applications such as Enhanced Geothermal Systems (EGS) and CO2 sequestration. We present a transformer-based deep learning approach for predicting the spatiotemporal evolution of MEQs. The model is trained on hydraulic stimulation history and monitored MEQ events from the EGS Collab field experiment data. Our transformer network accurately forecasts MEQ occurrences, energy release, and spatial extent, even for unseen datasets. Notably, the predicted spatial extents after the fluid injection period were within 0.36 meters of observed values, demonstrating the model's robustness in capturing the spatial characteristics of fluid-induced seismicity. These results underscore the significant potential of deep learning approaches to accurately forecast MEQs, ultimately improving risk assessment, guiding mitigation strategies, and optimizing well placement in future geo-engineering operations.
Identification and Validation of Autophagy-Related Genes in Osteoarthritis through Bioinformatics and Machine Learning
Authors: Du Jian , Xie Congqin , Zhou Tian , Peng Wei 
Published: December 2024

Abstract

Osteoarthritis (OA) is a common degenerative joint disease affecting the elderly worldwide. Although increasing evidence suggests a close relationship between autophagy and OA, its pathogenesis remains unclear. This study aimed to identify autophagy-related genes in OA using bioinformatics and machine learning methods. Three OA datasets (GSE55235, GSE55457 and GSE12021) were retrieved from the GEO database for differential analysis. Subsequently, differentially expressed genes (DEGs) were intersected with autophagy-related genes to identify differentially expressed autophagy-related genes (DEARGs), which were then subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Subsequently, potential key genes were selected using three machine learning algorithms (LASSO, SVM and RF) and their diagnostic accuracy was validated using an external dataset (GSE114007) to determine the key genes. Next, potential interactions between the key genes were predicted using the GeneMANIA database. Additionally, immune cell infiltration analysis was performed to explore the correlation between the key genes and immune cells. Finally, the expression levels of the key genes were further validated using quantitative real-time polymerase chain reaction (qRT-PCR). In this study, a total of 27 DEARGs were identified. GO and KEGG enrichment analyses indicated that these DEARGs might be associated with pathways related to cellular immunity, autophagy, and inflammation. Four potential key genes were selected through the use of three machine learning algorithms. Notably, validation with the external dataset revealed that the expression levels of PPP1R15A, GABARAPL1 and FOXO3 were significantly downregulated in OA and exhibited strong diagnostic performance. Immune infiltration analysis showed that PPP1R15A, GABARAPL1 and FOXO3 were positively correlated with activated mast cells and resting memory CD4 + T cells, but negatively correlated with plasma cells and M0 macrophages. Finally, qRT-PCR confirmed these results, which were consistent with the bioinformatics analysis.In conclusion, this study identifies PPP1R15A, GABARAPL1 and FOXO3 as autophagy key genes in OA, providing potential targets for the diagnosis and treatment of OA.
Psychological Stress and associated factors among Infertile Women seeking treatment at St. Paul’s Hospital Millennium Medical College Michu clinic in Ethiopia
Authors: Yohannes Metages , Abebe Mitswat , Birhanu Adamu , Damtew Solomon Abrha 
Published: December 2024

Abstract

Background: Infertility and infertility induced psychological stress are the major reproductive health problem that women across the globe are facing. The problem is more pronounced in developing countries. In Ethiopia, this is coupled with the scarcity of specialized fertility treatment centers which provide treatment and care for infertility. There is limited knowledge regarding the psychological stress experienced by infertile women in Ethiopia, particularly among infertile women seeking treatment from specialized infertility treatment centers.
Objectives: The aim of this study was to assess the level of psychological stress and its associated factors among infertile women seeking treatment at St. Paul’s Hospital Millennium Medical College Michu clinic.
Methods: Facility based cross-sectional study was conducted among 94 infertile women seeking treatment for infertility at St. Paul’s Hospital Millennium Medical College, Ethiopia from March 01-30/ 2024 by using consecutive sampling technique. Data were collected using interviewer administered questionnaire by using Kobo Tool Box and collected data were exported to STATA Version16 for analysis. Frequencies and percentages were used for categorical variables and mean and standard deviation for continuous variables. Binary logistic regression analysis model was run to identify important predictors. Adjusted odds ratio (AOR) with 95% confidence interval was estimated to identify the strength of association. Statistical significance was declared at p-value 0.05.
Results: The proportion of infertile women who reported experiencing higher level of psychological stress was 43% (95% CI 33.24%, 53.34%). Infertile women from rural area [AOR=34.00 (95%CI: 2.55, 452.444)], higher income [0.18= (95%CI: 0.04, 0.80)], those who did not have thyroid disease [AOR =0.05, (95% CI: 0.004, 0.62)] were factors significantly associated with psychological stress.
Conclusions: The prevalence of psychological stress was high among infertile women seeking treatment in the study facility. Infertility induced psychological stress was found to show variation by place of residence, income level and having the condition of thyroid. Activities and efforts targeting on rural residents which improve women economic empowerment and availing screening services for comorbidities such as Thyroid are hoped to address the growing problem of infertility. Creating awareness that the problem of infertility is treatable and equipping women with strategies and skills to cope with the pressure from significant others around them. The other implication of the study Miichu clinic workers need to screen for and provide counseling for clients coming for infertility care and support on infertility related psychosocial stress including linking with psychologists and psychiatrist so that they can get emotional care and support.
The Impact of Five-tone Music Therapy Combined with Compound Essential Oil Acupoint Massage on Postoperative Negative Emotions and Sleep Quality in Patients with Lumbar Disc Herniation
Authors: Liu Qinci , Chen Jiangwei , Zhou Jiangling , Xie Rong , Wu Jiali 
Published: December 2024

Abstract

Background: This study aims to explore the effects of five tone music (FMT) combined with compound essential oil acupoint massage on postoperative negative emotions and sleep quality in patients with lumbar disc herniation.
Methods: From January to July 2024, 86 patients undergoing their first lumbar fusion surgery were recruited and randomly divided into four groups using a random number table method. The groups were designated as the FMT group, the compound essential oil acupoint massage group, the combined therapy group, and the control group. The patients' scores on the Anxiety Scale (SAS), Depression Scale (SDS), Pittsburgh Sleep Quality Index (PSQI), and Visual Analogue Scale (VAS) for pain were recorded before and after the intervention.
Results: The combined therapy group showed significant reductions in SAS, SDS, PSQI, and VAS scores compared to the other three groups, with statistically significant differences (P < 0.05).
Conclusion: FMT combined with compound essential oil acupoint massage can effectively improve postoperative negative emotions, enhance sleep quality, and reduce postoperative pain in patients with lumbar disc herniation.
Trial registration: ChiCTR2400087308;
Date of Registration:July 24, 2024.
MiR-486-5p-modified sEVs encapsulated in GelMA hydrogel facilitated wound healing by targeting Smurf2/TGF-β1 pathways
Authors: Wang Siyu , Zhou Ziyu , Lv Kunyu , Liu Yan , Feng Lixin , Zhang Mengdan , Toh Wei Seong , Hu Xiaoli 
Published: December 2024

Abstract

Sustained delivery of therapeutic agents such as small extracellular vesicles (sEVs) in biomaterial scaffolds is expected to bring new hope for chronic wound treatment. Although sEVs derived from mesenchymal stem cells (MSCs) have been demonstrated to promote wound healing, there are still challenges associated with inadequate angiogenesis, poor localization, and consequently suboptimal outcomes. Herein, we derived small extracellular vesicles (sEVs) from dental pulp stem cells (DPSCs) overexpressing miR-486-5p (sEV-486-5p) and encapsulated them in gelatin methacryloyl (GelMA) hydrogel for wound treatment. In this study, the sEVs derived from miR-486-5p overexpressing DPSCs (sEV-486-5p) with a ~14-fold increase in expression of miR-486-5p were found to improve angiogenic activities of human umbilical vein endothelial cells (HUVECs) in vitro. Further bioinformatics prediction and dual-luciferase reporter assay verified the binding between miR-486-5p and Smad ubiquitination regulatory factor 2 (Smurf2). Mechanistically, sEV-486-5ppromoted the angiogenic properties of HUVECs by increasing the TGF-β1 protein expression and Smad2 phosphorylation, while decreasing the Smurf2 expression. Upon knockdown of Smurf2, the angiogenic activities of HUVECs were enhanced. Inhibition of TGF-β1/Smad2 pathway using SB431542 also suppressed angiogenesis induced by sEV-486-5p. sEV-486-5p encapsulated in GelMA hydrogel exhibited sustained release and accelerated wound healing by enhancing angiogenesis. Overall, GelMA hydrogel encapsulating sEV-486-5p can promote wound healing through miR-486-5p-mediated angiogenesis, thus representing an innovative approach for wound management.
The Trajectory of KoRV-A Evolution Indicates Initial Integration into the Koala Germline Genome Near Coffs Harbour
Authors: Yu Tianxiong , Blyton Michaela B.J. , Koppetsch Birgit S. , Abajorga Milky , Luban Jeremy , Chappell Keith , Theurkauf William E. , Weng Zhiping 
Published: December 2024

Abstract

Background
Koala Retrovirus-A is a gamma-retrovirus that is spreading across wild koala populations through horizontal and vertical transmission, contributing significantly to genomic diversity across and even within koala populations. Previous studies have estimated that KoRV-A initially integrated into the koala genome less than 50,000 years ago, but the precise origins and the patterns of spread after its endogenization remain unclear.
Results
In this study, we analyzed germline insertions of KoRV-A using whole-genome sequencing data from 405 wild koalas, representing nearly the species’ entire geographic range. Our findings reveal an evolutionary trajectory for KoRV-A, suggesting that the initial endogenization might occur near Coffs Harbour on the Mid-north coast of NSW around the middle of the koala’s range. As KoRV-A spread, certain subtypes emerged and became prevalent, two of which recombined with an ancient endogenous retrovirus, PhER, resulting in distinct recombination variants in northern and southern koala populations. Additionally, we identified a geographic barrier north of Sydney, which may have slowed the southward spread of KoRV-A into Sydney and beyond.
Conclusions
Our study proposes a comprehensive evolutionary pathway for KoRV-A, beginning with its initial endogenization near Coffs Harbour and highlighting barriers and diversification events that have shaped its distribution and impact on koala populations.
OPTIMIZING GOVERNMENT POLICIES TO SUPPORT SUSTAINABLE SHARIA-BASED TOURISM
Authors: Fitria Mirza Nur , Caspari Andrean , Setiawan Arvan 
Published: December 2024

Abstract: This paper examines the optimization of government policies to support sustainable sharia-based tourism, a sector that is gaining prominence in the global tourism landscape, particularly among Muslim travelers. The study begins by exploring the current state of sharia-based tourism in various regions, highlighting its economic and cultural significance. It identifies the critical role of government policies in creating an enabling environment for the development of this sector while ensuring compliance with Islamic principles. The findings reveal significant gaps in the current policy framework, emphasizing the need for clear regulatory standards, enhanced infrastructure, and targeted marketing strategies. Additionally, the study underscores the importance of community engagement and capacity building to foster local participation in sharia-based tourism. The paper concludes with evidence-based recommendations for policymakers aimed at optimizing government interventions to promote sustainable sharia-based tourism, thus contributing to economic growth, cultural preservation, and the overall well-being of communities involved in this burgeoning sector.
Keywords: Government Policies; Sharia-Based Tourism; Halal Tourism.

Abstrak: Paper ini membahas optimasi kebijakan pemerintah untuk mendukung pariwisata berbasis syariah yang berkelanjutan, suatu sektor yang semakin mendapatkan perhatian dalam lanskap pariwisata global, terutama di kalangan pelancong Muslim. Penelitian ini dimulai dengan mengeksplorasi keadaan saat ini dari pariwisata berbasis syariah di berbagai wilayah, menyoroti signifikansi ekonomi dan budaya sektor ini. Penelitian ini mengidentifikasi peran penting kebijakan pemerintah dalam menciptakan lingkungan yang mendukung pengembangan sektor ini sambil memastikan kepatuhan terhadap prinsip-prinsip Islam. Temuan menunjukkan adanya kesenjangan signifikan dalam kerangka kebijakan saat ini, menekankan perlunya standar regulasi yang jelas, infrastruktur yang ditingkatkan, dan strategi pemasaran yang terarah. Selain itu, studi ini menekankan pentingnya keterlibatan komunitas dan pengembangan kapasitas untuk mendorong partisipasi lokal dalam pariwisata berbasis syariah. Makalah ini diakhiri dengan rekomendasi berbasis bukti untuk pembuat kebijakan yang bertujuan untuk mengoptimalkan intervensi pemerintah guna mempromosikan pariwisata berbasis syariah yang berkelanjutan, sehingga berkontribusi pada pertumbuhan ekonomi, pelestarian budaya, dan kesejahteraan masyarakat yang terlibat dalam sektor yang berkembang ini.
Kata Kunci: Kebijakan Pemerintah; Pariwisata Berbasis Syariah; Pariwisata Halal.