bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Screening Tool for Common Mental Disorders Among General Hospital Inpatients in China
Authors: Yuan Shuai , Shen Yizhong , Liu Jingwen , Chen Zilin , Zheng Lijiao , Chen Lihao , Chen Hanwei , Feng Huiqiang , He Hongbo 
Published: December 2021

Background: Depression and anxiety disorders are common conditions among general hospital inpatients, but are believed to be under-recognized in China.Methods: A short, practical questionnaire termed the happiness index scale (HIS) was developed for screening co-morbid mental disorders in non-psychiatric clinical settings. The HIS was completed by 1,005 non-psychiatric inpatients in a general hospital in China. The reliability and validity of the HIS were then assessed.Results: The HIS comprised eight items which loaded onto four dimensions: (a) sleep quality; (b) suicidal tendency; (c) depression; and (d) anxiety. These dimensions explained 84.2% of the total variance. Confirmatory factor analysis showed reasonably good fit of the four-factor model (χ2/df = 1.27, p &lt; 0.001, goodness-of-fit index = 0.95, comparative fit index = 0.99, root-mean-square error of approximation = 0.008). The correlation coefficients between each item and the corresponding factor were all &gt; 0.5. Cronbach's α of the entire scale was 0.83, indicating good internal consistency. The area under the ROC curve was 0.95 compared with the original 31-item scale. Using the optimal cut-off score of HIS (mild happiness), the sensitivity and specificity were 0.933 and 0.882, respectively.Conclusions: The new HIS scale is a practical screening tool composed of eight items covering the four most common and important dimensions of mental disorder. The HIS exhibited good reliability and specificity. The HIS is potentially suitable for large-scale screening in busy non-psychiatric clinical settings in China. Further verification using larger samples is warranted.
Bioprinted Cancer Model of Neuroblastoma in a Renal Microenvironment as an Efficiently Applicable Drug Testing Platform
Authors: Wu Dongwei , Berg Johanna , Arlt Birte , Röhrs Viola , Al-Zeer Munir A. , Deubzer Hedwig E. , Kurreck Jens 
Published: December 2021

Development of new anticancer drugs with currently available animal models is hampered by the fact that human cancer cells are embedded in an animal-derived environment. Neuroblastoma is the most common extracranial solid malignancy of childhood. Major obstacles include managing chemotherapy-resistant relapses and resistance to induction therapy, leading to early death in very-high-risk patients. Here, we present a three-dimensional (3D) model for neuroblastoma composed of IMR-32 cells with amplified genes of the myelocytomatosis viral related oncogene MYCN and the anaplastic lymphoma kinase (ALK) in a renal environment of exclusively human origin, made of human embryonic kidney 293 cells and primary human kidney fibroblasts. The model was produced with two pneumatic extrusion printheads using a commercially available bioprinter. Two drugs were exemplarily tested in this model: While the histone deacetylase inhibitor panobinostat selectively killed the cancer cells by apoptosis induction but did not affect renal cells in the therapeutically effective concentration range, the peptidyl nucleoside antibiotic blasticidin induced cell death in both cell types. Importantly, differences in sensitivity between two-dimensional (2D) and 3D cultures were cell-type specific, making the therapeutic window broader in the bioprinted model and demonstrating the value of studying anticancer drugs in human 3D models. Altogether, this cancer model allows testing cytotoxicity and tumor selectivity of new anticancer drugs, and the open scaffold design enables the free exchange of tumor and microenvironment by any cell type.
Effect of Nutritional Factors and Copper on the Regulation of Laccase Enzyme Production in Pleurotus ostreatus
Authors: Durán-Sequeda Dinary , Suspes Daniela , Maestre Estibenson , Alfaro Manuel , Perez Gumer , Ramírez Lucía , Pisabarro Antonio G. , Sierra Rocío 
Published: December 2021

This research aimed to establish the relationship between carbon–nitrogen nutritional factors and copper sulfate on laccase activity (LA) by Pleurotus ostreatus. Culture media composition was tested to choose the nitrogen source. Yeast extract (YE) was selected as a better nitrogen source than ammonium sulfate. Then, the effect of glucose and YE concentrations on biomass production and LA as response variables was evaluated using central composite experimental designs with and without copper. The results showed that the best culture medium composition was glucose 45 gL−1 and YE 15 gL−1, simultaneously optimizing these two response variables. The fungal transcriptome was obtained in this medium with or without copper, and the differentially expressed genes were found. The main upregulated transcripts included three laccase genes (lacc2, lacc6, and lacc10) regulated by copper, whereas the principal downregulated transcripts included a copper transporter (ctr1) and a regulator of nitrogen metabolism (nmr1). These results suggest that Ctr1, which facilitates the entry of copper into the cell, is regulated by nutrient-sufficiency conditions. Once inside, copper induces transcription of laccase genes. This finding could explain why a 10–20-fold increase in LA occurs with copper compared to cultures without copper when using the optimal concentration of YE as nitrogen sources.
COLLECTIVE AND INDIVIDUAL ASPECTS OF THE INNOVATIVE APPROACH TO THE MANAGEMENT OF THE SKILLS OF THE MANAGER OF THE SPORTS INSTITUTION
Authors: DENISOVETS T. , PIVOVAR N. , KVAK O. 
Published: December 2021

The article analyzes both the phenomena of innovative perception of reality by a modern leader, his innovative thinking, and the challenges that determine their relevance. The main tasks set before the head of the educational institution of the realities of the post-Soviet space are considered from the standpoint of social, educational, cultural in the context of the transition to market forms of management.
The aim of the article is to reveal the modern requirements for the professional skills of the head of an educational institution (in particular, sports), as a person with innovative thinking, able to find the optimal balance between collective and individual.
It is noted that the correct training of managerial staff in pedagogy means as its end product of individually strong children who are able to work productively in teams, rather than the gray mass. Therefore, the head of the educational institution (and sports education institution – in the first place) must be able to separate individual and collective interests, balance them, choosing an effective strategy for educating young people as members of a new society, its vanguard and democratic social views.
Accessing primary care and the importance of ‘human fit’: a qualitative participatory case study
Authors: Voorhees Jennifer , Bailey Simon , Waterman Heather , Checkland Kath 
Published: December 2021

BackgroundGood access to primary care is an important determinant of population health. While the academic literature on access to care emphasises its complexity, policies aimed at improving access to general practice in the UK have tended to focus on measurable aspects, such as timeliness or number of appointments.AimTo fill the gap between the complex understanding of primary care access in the literature and the narrow definition of access assumed in UK policies.Design and settingQualitative, community-based participatory case study within the geographic footprint of a clinical commissioning group in the north west of England. Data collection took place from October 2015 to October 2016. Purposive sampling and snowball approaches were used to achieve maximum variation among service users and providers across general practice settings.MethodLevesque et al’s conceptual framework of patient-centred access was applied and the study used multiple qualitative methods (interviews, focus groups, and observation). Analysis was ongoing, iterative, inductive, and abductive with the theory.ResultsThe comprehensiveness of Levesque et al’s access theory resonated with diverse participant experiences. However, while its strength was to highlight the importance of people’s abilities to access care, this study’s data suggest equal importance of healthcare workforce abilities to make care accessible. Thus, the authors present a definition of access as the ‘human fit’ between the needs and abilities of people in the population and the abilities and capacity of people in the healthcare workforce, and provide a modified conceptual framework reflecting these insights.ConclusionAn understanding of access as ‘human fit’ has the potential to address longstanding problems of access within general practice, focusing attention on the need for staff training and support, and emphasising the importance of continuity of care.
inteligencia artificial en la Educación Física en tiempo de COVID 19
Authors: Toala Pilay Marco Antonio , Romero Castro Vicente Fray , Romero Castro Martha Irene , Romero Castro Rosario  Magdalena 
Published: December 2021

La Inteligencia Artificial, al igual que otras tecnologías disruptivas, son hoy un espacio de innovación para la educación en época del COVID. Este estudio tributo al proyecto de investigación de la universidad estatal del sur de Manabí: la enseñanza constructivista sustentado en la inteligencia artificial. Determinar el enfrentamiento de alumnos y profesores, las clases de Educación Física en aislamiento. Se realizó un estudio descriptivo y transversal en 7 profesores y 28 estudiantes, se manejaron algunas variables: metodología física del trabajo de educación a distancia, situación de aislamiento pandémico. 75% estudiantes señalaron la eficiencia de las capsulas educativas más didáctica que las guías educativas, el 100 % profesores el refieren lo difícil de la utilización de las clases online, pero a la vez son muy motivadoras. Las educaciones físicas virtuales se han convertido en herramientas eficaces que pueden contribuir a la calidad de vida de las personas aisladas.
Digitalization of Agriculture in Northern Baragan, by Using Drones, for the Purpose of Monitoring Crops, to Increases the Efficiency of Agricultural Technologies
Authors: LEOPA Adrian , TRIFAN Daniela , BARDAHAN Valentin , HAUK Niculai 
Published: December 2021

With the increase of the population appeared the need to increase the agricultural production. However, this desideratum comes with a series of requirements that are somewhat contradictory:
- reducing the use of pesticides; - reducing the quantities of agricultural fertilizers by optimizing their use;
- the use of more environmentally friendly technologies;
- cost reduction.
Thus appeared the concept of "precision agriculture" that meets the requirements listed. This concept involves processing a large volume of digitized data. The data must be purchased with appropriate means, processed with specialized software and interpreted by qualified specialists.
The software also generates the data necessary for the practical application, on farms, of the measures necessary to achieve a precision agriculture.
الكتاب في فقرة
Authors: الحوامدة إيصال صالح 
Published: December 2021

الدين والقيم محورية التزكية الروحية في بناء المجتمع، محمد حلمي عبد الوهاب، القاهرة: نيوبوك للنشر والتوزيع، ط1، 2020، 160 صفحة
القيم الوطنية في المناهج التعليمية، مفتاح بن هدية، عمّان: دار الأيام للنشر والتوزيع، ط1، 2020، 288 صفحة
القيم الأخلاقية في المجتمع العربي بين النظرية والممارسة، مجموعة من الباحثين، تنسيق: نسيسة فاطمة الزهراء، عمّان: دار الأيام للنشر والتوزيع، ط1، 2020، 3 مجلدات، 898 صفحة
المسلمون والغرب والتأسيس القرآني للمشترك الإنساني، أحمد الفراك، فرجينيا: المعهد العالمي للفكر الإسلامي، ط1، 2021، 392 صفحة
المشترك الإنساني والتواصل الحضاري والديني أية أرضية؟ وأي أفق؟، مجموعة مؤلفين، تنسيق أحمد الفراك وعبد الباسط المستعين، عمّان: دار ركاز للنشر والتوزيع، ط1، 2021، 515 صفحة
قيمنا الإسلامية والتسارع الحضاري كيف نتعامل مع معطيات الحضارة المعاصرة، يوسف الملّا، القاهرة: دار السلام للطباعة والنشر والتوزيع والترجمة، ط1، 2020، 336 صفحة
إدارة الجودة الشاملة في التعليم، خالد الصرايرة ورضا المواضيه وخالد الزيديين، عمّان: دار وائل للطباعة والنشر والتوزيع، ط1، 2019، 223 صفحة
القيم الأخلاقية الواردة في كتب التربية الإسلامية "كتب المرحلة المتوسطة من التعليم الأساسي بلبنان"، شيرين خورشيد، بيروت: نشر خاص، 2019، 280 صفحة
تطوير تقويم أداء كليات جامعة الملك سعود في ضوء مدخل القيمة المضافة، عبد اللطيف ابن عبد الله، القاهرة: المنظمة العربية للتنمية الإدارية، ط1، 2019، 223 صفحة
حوكمة المؤسسات في ضوء الفكر المعاصر، سامح عامر وياسمين السنطيل، الأردن: دار الفكر للنشر والتوزيع، ط1، 2020، 408 صفحة
أنثروبولوجيا الفقه الإسلامي: التعليم والأخلاق والاجتهاد الفقهي في الأزهر، آريا نكسا، بيروت: مركز نهوض للدراسات والبحوث، ط1، 2021م، 511 صفحة
منظومة القيم المقاصدية وتجلياتها التربوية، فتحي حسن ملكاوي، عمّان: المعهد العالمي للفكر الإسلامي، ط1، 2020م، 287 صفحة
The Value of Critical Knowledge, Ethics and Education: Philosophical History Bringing Epistemic and Critical Values to Values, by Ignace Haaz, geneva: net, June 2019, 234 pages.
Islamic Law and Ethics, Edited by David R. Vishanoff , Herndon: The International Institute of Islamic Thought, June, 2020, 222 pages.
Value and the Humanities: The Neoliberal University and Our Victorian Inheritance (Palgrave Studies in Literature, Culture and Economics, by Zoe Hope Bulaitis, Edinburgh: Palgrave Macmillan, June 2020, 326
How to Market a university: Building Value in a Competitive Environment, by Teresa Flannery, Baltimore: Johns Hopkins University Press, January 2021, 256
Higher Expectations: Can Colleges Teach Students What They Need to Know in the 21st Century? by Derek Bok, New Jersey: Princeton University Press, August 2020, 232
Cracks in the Ivory Tower: The Moral Mess of Higher Education, by Jason Brennan and Phillip Magness, UK: Oxford University Press, June 2021, 176
Teaching the Whole Student: Engaged Learning With Heart, Mind, and Spirit, Editing by David Schoem & Christine Modey, & Edward P. St. John, Stylus Publishing, May 2017, 292
Pengaruh Penghargaan (Reward), Budaya Kerja Dan Harapan Berkembang Terhadap Kinerja Anggota Kepolisian Di Direktorat Reserse Kriminal Khusus (Ditreskrimsus) Polda Kalimantan Selatan
Authors: Sheren Septiana  
Published: December 2021

Abstrak: Sheren Septiana, Npm. 1811.32202.4740, Pengaruh Penghargaan (Reward), Budaya Kerja Dan Harapan Berkembang Terhadap Kinerja Anggota Kepolisian Di Direktorat Reserse Kriminal Khusus (Ditreskrimsus) Polda Kalimantan Selatan, Dibawah Bimbingan Arief Noviarakhman Dan Melania, 2020. Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui dan menganalisis pengaruh penghargaan (reward) terhadap kinerja anggota kepolisian, untuk mengetahui dan menganalisis pengaruh budaya kerja terhadap kinerja anggota kepolisian dan untuk mengetahui dan menganalisis pengaruh harapan berkembang terhadap kinerja anggota kepolisian di Direktorat Reserse Kriminal Khusus (Ditreskrimsus) Polda Kalimantan Selatan.Populasi dan sampel dalam penelitian ini adalah 36 orang anggota kepolisian Ditreskrimsus Polda Kalimantan Selatan. Jenis datan penelitian asosiatif dengan paradigma kuantitatif, menggunakan perhitungan statistik dengan program SPSS 17 dengan analisis regresi berganda. Hasil penelitian pertama diketahui bahwa variabel penghargaan (reward) berpengaruh signifikan terhadap kinerja anggota kepolisian di Direktorat Reserse Kriminal Khusus (Ditreskrimsus) Polda Kalimantan Selatan. Hasil penelitian kedua diketahui bahwa variabel budaya kerja berpengaruh signifikan terhadap kinerja anggota kepolisian di Direktorat Reserse Kriminal Khusus (Ditreskrimsus) Polda Kalimantan Selatan. Hasil penelitian ketiga diketahui bahwa variabel harapan berkembang berpengaruh signifikan terhadap kinerja anggota kepolisian di Direktorat Reserse Kriminal Khusus (Ditreskrimsus) Polda Kalimantan Selatan.
Kata Kunci: Penghargaan, Budaya Kerja, Harapan Berkembang dan Kinerja
Teodor Iljaszewicz (1910-1948)
Authors: Głogowska Helena 
Published: December 2021

Postać Teodora Iljaszewicza na trwale wpisała się w historię literatury białoruskiej i białoruskiego ruchu narodowego, szczególnie poczynając od lat 90. XX w., gdy powstała niepodległa Republika Białoruś. Jego nazwisko znalazło się w encyklopediach i słownikach biograficznych. Przedstawia się go jako białoruskiego poetę, prozaika, historyka, dziennikarza i działacza społeczno-kulturalnego. Pomija się zaś jego podstawowy zawód nauczyciela i pedagoga, który był dla niego nie tylko źródłem utrzymania, ale też pasją i powołaniem. Jego działalność w dziedzinie oświaty białoruskiej – zarówno pedagogiczna, jak i organizacyjna zasługują na odrębne zainteresowanie. Po ukończeniu studiów bowiem poświęcił się jej bezgranicznie. Bez względu na okoliczności starał się kształcić młodzież białoruską w języku ojczystym. W II Rzeczypospolitej w latach 1934-1937 uczył języka białoruskiego w Wileńskim Gimnazjum Białoruskim i w Prawosławnym Seminarium Duchownym w Wilnie. W latach 1939-1941 oraz 1941-1944 organizował szkolnictwo białoruskie na Białostocczyźnie, a w latach 1944-1948 w warunkach emigracji w powojennych Niemczech uczył dzieci i młodzież, wydawał podręczniki, organizował skauting i YMCA. Spojrzenie całościowe na życie i działalność Teodora Iljaszewicza wskazuje, jak ważną w jego życiu była działalność oświatowa, można nawet stwierdzić, że traktował ją priorytetowo, zaś twórczość literacka i naukowa była jej uzupełnieniem.
Effect of COVID-19 on development and progression of endocrinopathies in children
Authors: Lazareva M. A. , Evseeva G. P. , Suprun S. V. , Rakitskaya E. V. , Lebed’ko O. A. 
Published: December 2021

Introduction. An outbreak of coronavirus (COVID-19) declared an emergency of international public health importance. More information is now available on how COVID-19 affects people, including children and adolescents. SARS-CoV-2 is a new virus, and so far, there is insufficient data on what endocrinopathies it can cause in children, and how it affects patients with a history of endocrine pathology. Aim. Review containing data from foreign studies on the effects of coronavirus infection on the development and progression of child and adolescent endocrinopathies. Materials and methods. An analysis of publications containing data from studies of COVID-19 cases in children was carried out. Results. Currently, foreign studies indicate the provoking effect of COVID-19 on the development and progression of endocrinopathies in children and adolescents. Conclusion. Future studies should include a comprehensive assessment of the endocrine system during the acute phase and recovery phase after undergoing COVID-19, as there is no long-term follow-up until the significant impact of this virus on the development of endocrinopathies in children can be ruled out.
TRPA1-mediated effects on the functional activity of macrophages under the exposure with cigarette smoke and cinnamaldehyde
Authors: Sugaylo I. Yu. , Naumov D. E. , Kotova O. O. , Gassan, D. A. , Gorchakova Ya. G. 
Published: December 2021

Introduction. Being the leading cause of COPD, smoking represents a major health problem. Upon entering the respiratory tract, cigarette smoke comes into contact with various cells, including macrophages expressing on their surface TRPA1 receptors, which are sensitive to the main pathogenic compounds formed during tobacco combustion.Aim. To study the functional activity of TRPA1 channels on macrophages in terms of cell responses to cigarette smoke and the TRPA1 agonist cinnamaldehyde (CA). Materials and methods. The experimental conditions included exposure of monocyte-derived macrophages to CA (100 μM), 4% cigarette smoke extract (CSE) and 4% CSE after pretreatment with TRPA1 selective antagonist (HC-030031 100 μM). The concentration of cytokines in the culture medium, the expression of TRPA1 on the cell surface, as well as the phagocytic activity of macrophages were analyzed by flow cytometry.Results. We found that 60.2 (49.6; 71.8)% of cells expressed TRPA1 and their number increased after exposure with CA. CSE significantly inhibited CXCL10 production from 1121.3 (295.7; 3154.6) pg/ml to 187.9 (113.8; 398.3) pg/ml (p=0.04), which was partially prevented by blocking TRPA1 (692.4 [428.6; 2916.6] pg/ml, p=0.04). Similar to CSE, CA also caused a decrease in CXCL10 concentration (189.2 [111.7; 311.3] pg/ml, p=0.03). Among other observations, there was an increase in the concentration of IL-1β after the exposition with HC-030031, as well as a decrease in TNF-α, IFN-γ and IL-12p70 after the treatment with CA. CSE caused a minor inhibition in phagocytic cells number, which was not prevented by TRPA1 blocking. CA, on the contrary, increased the phagocytic activity of macrophages. The initial expression of TRPA1 had a negative correlation with the dynamics of CXCL10 in response to CSE and CA but a positive correlation with the number of phagocytic cells after exposition with CA (ρ=0.81, p=0.005). Conclusions. TRPA1 expressed on macrophages apparently mediate an anti-inflammatory effect in terms of produced cytokines but increase phagocytic activity of the cells. TRPA1 are also major receptors involved in the diminished CXCL10 production by macrophage under exposition with cigarette smoke
Effect of the water-soluble cholesterol-methyl-β-cyclodextrin complex on the development of pulmonary edema with an analysis of the osmotic resistance of erythrocytes in rats
Authors: Kobzar N. E. , Mikhailov V. P. , Porseva V. V. 
Published: December 2021

Introduction. Methyl-β-cyclodextrin is a potent acceptor of cellular membrane cholesterol and, at the same time, used as a solubilizer, which makes it a potential target for targeted delivery of hydrophobic compounds.Aim. To assess the effect of administration of methyl-β-cyclodextrin containing cholesterol on the degree of lung hydration and osmotic resistance of erythrocytes against the background of pulmonary edema in adult rats caused by the administration of mezaton.Materials and methods. We investigated the degree of hydration of the lungs by the value of the pulmonary coefficient and their dry residue. Osmotic resistance of erythrocytes were assessed by the intensity of their hemolysis in a series of hypotonic sodium chloride solutions in adult male Wistar rats (220±40 g) of the control group (intact, n=10) and two experimental groups with pulmonary edema caused by the administration of mezaton (n=10) and with the subsequent introduction of a water-soluble complex cholesterol-methyl-β-cyclodextrin against the background of the development of pulmonary edema (n=10). We used additional criteria for assessing the osmotic resistance of erythrocytes: minimum resistance – the concentration of sodium chloride solution, at which the first “weak” erythrocytes begin to hemolyze; maximum resistance is the concentration of sodium chloride solution at which all or almost all erythrocytes hemolyzed.Results. The introduction of mezaton led to the development of pronounced hemolysis and hydration of the lungs with the development of their edema and a narrowing of the range of minimum and maximum osmotic resistance of erythrocytes. The introduction of a complex of cholesterol with methyl-β-cyclodextrin after edemogenic exposure led to a decrease in the severity of pulmonary edema, determined by a decrease in the pulmonary coefficient and an increase in the dry residue, and to an increase in the osmotic resistance of erythrocytes with an expansion of the range of their minimum and maximum osmotic resistance.Conclusion. The introduction of a water-soluble complex of cholesterol with methyl-β-cyclodextrin against the background of the development of hemodynamic pulmonary edema significantly reduced the degree of hydration of the lungs, which combined with an increase in the osmotic resistance of erythrocytes.