bluuebunny/crossref_metadata_2025_split huggingface dataset:
Síndrome de Parry Romberg
Authors: Redondo Bermúdez César , Redondo De Oro Katherine , Mendoza Suárez Liney , Barrios Barreto Rina , Buj Vargas Julián 
Published: January 2021

Introducción: la hemiatrofia facial progresiva o síndrome de Parry Romberg es una enfermedad rara, de curso clínico lento, que genera atrofia de los tejidos blandos.Compromete frecuentemente un lado de la cara, siendo el izquierdo al parecer el más afectado. La entidad se establece usualmente a edades tempranas y con el tiempo puede comprometer una o varias ramas del nervio trigémino. Se presenta un caso con diagnóstico notoriamente tardío, pese a repetidas consultas por asimetría facial y otrasmanifestaciones.Caso clínico: paciente femenino de 73 años de edad, natural y residente en área rural colombiana, con numerosas consultas por presentar asimetría facial, sin que le ofreciesen diagnóstico definido. Antecedente de trauma cigomático y del hombro derecho dos décadas antes. Dos cirugías oftalmológicas: una por cataratas y otra por glaucoma. Se observó depresión notoria en mejilla derecha con signos marcados deatrofia, acompañado de cefaleas migrañosas periódicas y síntomas locales. Se realizó biopsia de piel donde se observó atrofia de los anexos cutáneos. No se demostraron otras lesiones neurológicas.Conclusión: el síndrome de Parry Romberg es una entidad crónica que puede tener implicaciones oftalmológicas o neurológicas. Involucra síntomas migrañosos, parestesias y asimetría facial, que ameritan temprano diagnóstico y tratamiento adecuado, tanto de la fase progresiva como estacionaria. Rev.cienc.biomed. 2015;6(1):142-149
Tumor glioneuronal papilar en fosa posterior
Authors: Tuñón Pitalúa Martha Cecilia , Ruiz Cáez Karina María , Niño Hernández Lucía Mercedes , Benedetti Isaac Juan Carlos , Alcalá Cerra Gabriel , Remolina López Anderson Julián 
Published: January 2021

Introducción: el tumor glioneuronal papilar (TGNP) es una entidad rara y de reciente tipificación. De probable origen en las células pluripotenciales de la placa subependimaria, que está ubicada principalmente alrededor de las astas temporales de los ventrículos laterales. En dichos sitios típicamente se presentan estas neoplasias.Caso clínico: se presenta un caso atípico de TGNP en una paciente de 48 años de edad, con tumor que comprometía el vermis inferior y ambos hemisferios cerebelosos.Conclusión: el TGNP se ubica generalmente en el espacio supratentorial. No obstante, se ha señalado la existencia de células pluripotenciales en la placa subependimaria, alrededor del área postrema, en la eminencia media del piso del cuarto ventrículo y en el plexo coroideo, ello pudiese explicar la exótica ocurrencia de TGNP en la fosa posterior. Rev.cienc.biomed. 2015;6(1):150-154
Investigation of Different Laboratory Aging Methods of Bituminous Mixtures
Authors: Durmaz Cagla , Sengoz Burak , Kaya Ozdemir Derya , Topal Ali 
Published: January 2021

The predicted performance and service life of the pavement depend largely on the properties of bitumen used in the mixtures. The most important feature of bitumen, which has profound effect on the performance of the road is durability. The durability of bitumen is expressed as the resistance to aging. In this study, the bituminous mixture aging was performed instead of bitumen aging in order to represent the aging in the field in the best possible way. The aim of this paper is to evaluate different proposed laboratory aging methods (NCHRP 09-52, NCHRP 09-54 and RILEM) in relation with the current Standard AASHTO R30 (Standard Practice For Mixture Conditioning of Hot Mix Asphalt standard) and to make comparison with the samples performance taken from the field in terms of Indirect Tensile Strength (ITS). The level of aging has also been compared with the samples taken from recently constructed pavement surface and from the five years old pavement surface. Results depicted that, laboratory aging methods revealed the field aging properties on the unaged bitumen. Based on the results, 2 hours forced draft oven aging at 135°C is recommended as short term aging condition because, 2 hours or 4 hours short term forced draft oven aging did not yield significant variation in terms of ITS values. Additionally, 120 hours (5 days) oven aging of compacted samples at 85°C can be recommended as long term aging condition.
Аналіз можливостей капсульних нейронних мереж для вирішення проблем, пов'язаних з розпізнаванням зображень
Authors: Арсенюк В.С. , Барбарук В.М. 
Published: January 2021

У статті виконано огляд сьогочасних публікацій з досліджень щодо модифікацій базових алгоритмів маршрутизації, базової архітектури капсульної нейромережі та використовуваних даними мережами датасетів. На підставі аналізу та узагальнення зроблені висновки щодо принципів побудови таких мереж на сучасному етапі, вибору алгоритму маршрутизації та оптимізатора для складних наборів даних.
Розглянуто питання щодо можливості застосування капсульного підходу при побудові нейронної мережі з розпізнавання зображень для мобільних додатків.
Perfil agronômico, fermentativo e bromatológico da silagem obtida do consórcio entre milho e soja
Authors: Marques Karolyna Oliveira , Jakelaitis Adriano , Guimarães Kátia Cylene , Pereira Leandro Spíndola 
Published: January 2021

O consórcio de milho com leguminosas pode aumentar a qualidade da silagem e resultar em maior produtividade animal. Objetivou-se nesta pesquisa avaliar aspectos agronômicos das culturas consorciadas entre milho e soja, perfil fermentativo e bromatológico da silagem produzida, em função do arranjo espacial das plantas e tipos de adubação. Foram realizados dois ensaios com dois arranjos espaciais: ensaio 1 – arranjo simples com uma linha de milho alternada com uma linha de soja; ensaio 2 - arranjo duplo com duas linhas de milho alternada com uma linha de soja. O delineamento foi em blocos ao acaso em esquema fatorial 2x2+1, com quatro repetições. O primeiro fator constou de duas modalidades de adubação de semeadura na linha: somente no milho e em área total. O segundo fator pelas doses de 100 e 70 kg ha-1 de P2O5 e K2O, respectivamente; e de 150 e 95 kg ha-1 de P2O5 e K2O, respectivamente. O monocultivo de milho foi a testemunha. Após a colheita, o material foi ensilado por 60 dias. Não houve diferença estatística no rendimento de silagem entre tratamentos, apenas aumentos na produção de vagens de soja e na qualidade da silagem nas doses maiores de adubação. Os resultados mostram que a adição de soja na silagem de milho ocasiona maiores perdas durante o processo de fermentação, mas em contrapartida eleva os teores de proteína, extrato etéreo e de digestibilidade. Ressalta-se que um volumoso com essas características pode vir a suprir a suplementação proteica em dietas de ruminantes.
Cancer Radiation Therapy May Be Associated With Atrial Fibrillation
Authors: Apte Nachiket , Dherange Parinita , Mustafa Usman , Ya'qoub Lina , Dawson Desiree , Higginbotham Kathleen , Boerma Marjan , Morin Daniel P. , Gupta Dipti , McLarty Jerry , Mansour Richard , Dominic Paari 
Published: January 2021

Background: The association of atrial fibrillation (AF) with cancer and cancer types is inconclusive. Similarly, data regarding the association of AF with different cancer therapies are controversial.Objectives: To study the association of AF with cancer subtypes and cancer therapies.Methods: We studied all patients aged 18–89 years who presented to the Feist Weiller Cancer Center, with or without a diagnosis of cancer, between January 2011 and February 2016. Electronic health records were systematically queried for baseline demographics and ICD-9 and ICD-10 codes for specific co-morbidities. Patients with a diagnosis of AF were tabulated based on cross-validation with the ECG database and/or by recorded history. We assessed the prevalence and risk of AF based on cancer diagnosis, specific cancer type, and cancer therapy.Results: A total of 14,600 patients were analyzed. Compared to non-cancer patients (n = 6,801), cancer patients (n = 7,799) had a significantly higher prevalence of AF (4.3 vs. 3.1%; p &lt; 0.001). However, following correction for covariates in a multivariable logistic regression model, malignancy was not found to be an independent risk factor for AF (p = 0.32). While patients with solid tumors had a numerically higher prevalence of AF than those with hematological malignancies (4.3 vs. 4.1%), tumor type was not independently associated with AF (p = 0.13). AF prevalence was higher in patients receiving chemotherapy (4.1%), radiation therapy (5.1%), or both (6.9%) when compared to patients not receiving any therapy (3.6%, p = 0.01). On multivariable logistic regression, radiation therapy remained an independent risk factor for AF for the entire study population (p = 0.03) as well as for the cancer population (p &lt; 0.01).Conclusions: Radiation therapy for cancer is an independent risk factor for AF. The known association between cancer and AF may be mediated, at least in part, by the effects of radiation therapy.
The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations
Authors: Mussazhanova Zhanna , Rogounovitch Tatiana I. , Saenko Vladimir A. , Krykpayeva Ainur , Espenbetova Maira , Azizov Bauyrzhan , Kondo Hisayoshi , Matsuda Katsuya , Kalmatayeva Zhanna , Issayeva Raushan , Yeleubayeva Zhanar , Madiyeva Madina , Mukanova Aray , Sandybayev Marat , Bolsynbekova Saltanat , Kozykenova Zhanna , Yamashita Shunichi , Nakashima Masahiro 
Published: January 2021

ObjectiveRisk for developing papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is thought to be mediated by lifestyle, environmental exposures and genetic factors. Recent progress in the genome-wide association studies of thyroid cancer leads to the identification of several genetic variants conferring risk to this malignancy across different ethnicities. We set out to elucidate the impact of selected single nucleotide polymorphisms (SNPs) on PTC risk and to evaluate clinicopathological correlations of these genetic variants in the Kazakh population for the first time.MethodsEight SNPs were genotyped in 485 patients with PTC and 1,008 healthy control Kazakh subjects. The association analysis and multivariable modeling of PTC risk by the genetic factors, supplemented with rigorous statistical validation, were performed.ResultFive of the eight SNPs: rs965513 (FOXE1/PTCSC2, P = 1.3E-16), rs1867277 (FOXE1 5’UTR, P = 7.5E-06), rs2439302 (NRG1 intron 1, P = 4.0E-05), rs944289 (PTCSC3/NKX2-1, P = 4.5E-06) and rs10136427 (BATF upstream, P = 9.8E-03) were significantly associated with PTC. rs966423 (DIRC3, P = 0.07) showed a suggestive association. rs7267944 (DHX35) was associated with PTC risk in males (P = 0.02), rs1867277 (FOXE1) conferred the higher risk in subjects older than 55 years (P = 7.0E-05), and rs6983267 (POU5F1B/CCAT2) was associated with pT3–T4 tumors (P = 0.01). The contribution of genetic component (unidirectional independent effects of rs965513, rs944289, rs2439302 and rs10136427 adjusted for age and sex) to PTC risk in the analyzed series was estimated to be 30–40%.ConclusionGenetic factors analyzed in the present work display significant association signals with PTC either on the whole group analysis or in particular clinicopathological groups and account for about one-third of the risk for PTC in the Kazakh population.
Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis
Authors: Okuliarova Monika , Mazgutova Nikoleta , Majzunova Miroslava , Rumanova Valentina Sophia , Zeman Michal 
Published: January 2021

Dim light at night (dLAN) has become a pervasive part of the modern world, and growing evidence shows its association with increased health risks. Though this link is attributed to a disturbed circadian clock, the underlying mechanisms that can explain how circadian disruption from dLAN causes negative health effects remain unclear. Here, we exposed rats to a light–dark cycle (12:12 h) with low-intensity light at night (~2 lx) for 2 and 5 weeks and explored the steady-state pattern of circulating immune cells and renal immune-related markers, which are well controlled by the circadian clock. After 5 weeks, dLAN impaired the daily variation in several types of white blood cells, especially monocytes and T cells. Two-week dLAN caused a reduction in blood monocytes and altered gene expression of macrophage marker Cd68 and monocyte-attracting chemokine Ccl2 in the kidney. Interestingly, dLAN decreased renal 3-nitrotyrosine levels and resulted in up-regulation of the main endogenous antioxidant pathways, indicating a disturbance in the renal redox balance and an activation of compensatory mechanisms. These effects paralleled the altered renal expression of the molecular clock components and increased plasma corticosterone levels. Together, our results show that chronic exposure to dLAN weakened the circadian control of daily variation of circulating immune cells and disturbed renal immune and redox homeostasis. Consequences of this dLAN-disturbed immune balance on the ability of the immune system to cope with other challenges should by clarified in further studies.
Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer
Authors: Yang Xi , Qi Quan , Pan Yuefen , Zhou Qing , Wu Yinhang , Zhuang Jing , Xu Jiamin , Pan Mingyue , Han Shuwen 
Published: January 2021

ObjectiveThis study aimed to characterize the tumor-infiltrating T cells in moderately differentiated colorectal cancer.MethodsUsing single-cell RNA sequencing data of isolated 1632 T cells from tumor tissue and 1252 T cells from the peripheral blood of CRC patients, unsupervised clustering analysis was performed to identify functionally distinct T cell populations, followed by correlations and ligand-receptor interactions across cell types. Finally, differential analysis of the tumor-infiltrating T cells between colon cancer and rectal cancer were carried out.ResultsA total of eight distinct T cell populations were identified from tumor tissue. Tumor-Treg showed a strong correlation with Th17 cells. CD8+TRM was positively correlated with CD8+IEL. Seven distinct T cell populations were identified from peripheral blood. There was a strong correlation between CD4+TN and CD4+blood-TCM. Colon cancer and rectal cancer showed differences in the composition of tumor-infiltrating T cell populations. Tumor-infiltrating CD8+IEL cells were found in rectal cancer but not in colon cancer, while CD8+ TN cells were found in the peripheral blood of colon cancer but not in that of rectal cancer. A larger number of tumor-infiltrating CD8+ Tex (88.94%) cells were found in the colon cancer than in the rectal cancer (11.06%). The T cells of the colon and rectal cancers showed changes in gene expression pattern.ConclusionsWe characterized the T cell populations in the CRC tumor tissue and peripheral blood.
Semi-Automated Cell and Tissue Analyses Reveal Regionally Specific Morphological Alterations of Immune and Neural Cells in a Porcine Middle Cerebral Artery Occlusion Model of Stroke
Authors: Spellicy Samantha E. , Scheulin Kelly M. , Baker Emily W. , Jurgielewicz Brian J. , Kinder Holly A. , Waters Elizabeth S. , Grimes Janet A. , Stice Steven L. , West Franklin D. 
Published: January 2021

Histopathological analysis of cellular changes in the stroked brain provides critical information pertaining to inflammation, cell death, glial scarring, and other dynamic injury and recovery responses. However, commonly used manual approaches are hindered by limitations in speed, accuracy, bias, and the breadth of morphological information that can be obtained. Here, a semi-automated high-content imaging (HCI) and CellProfiler histological analysis method was developed and used in a Yucatan miniature pig permanent middle cerebral artery occlusion (pMCAO) model of ischemic stroke to overcome these limitations. Evaluation of 19 morphological parameters in IBA1+ microglia/macrophages, GFAP+ astrocytes, NeuN+ neuronal, FactorVIII+ vascular endothelial, and DCX+ neuroblast cell areas was conducted on porcine brain tissue 4 weeks post pMCAO. Out of 19 morphological parameters assessed in the stroke perilesional and ipsilateral hemisphere regions (38 parameters), a significant change in 3838 measured IBA1+ parameters, 3438 GFAP+ parameters, 3238 NeuN+ parameters, 3138 FactorVIII+ parameters, and 2838 DCX+ parameters were observed in stroked vs. non-stroked animals. Principal component analysis (PCA) and correlation analyses demonstrated that stroke-induced significant and predictable morphological changes that demonstrated strong relationships between IBA1+, GFAP+, and NeuN+ areas. Ultimately, this unbiased, semi-automated HCI and CellProfiler histopathological analysis approach revealed regional and cell specific morphological signatures of immune and neural cells after stroke in a highly translational porcine model. These identified features can provide information of disease pathogenesis and evolution with high resolution, as well as be used in therapeutic screening applications.
QT Interval Dispersion as a Predictor of Clinical Outcome in Acute Ischemic Stroke
Authors: Tang Hefei , Sun Jiayao , Wang Yu , Jie Xu , Ma Yan , Wang Anxin , Zhang Yijun , Wang Xingao , Wang Yongjun 
Published: January 2021

Background and Purpose: QT dispersion (QTd) abnormalities are widely documented in stroke patients. This study aims to investigate the association between QTd and clinical outcomes in IS patients.Methods: IS patients registered in the Blood Pressure and Clinical Outcome in transient ischemic attack (TIA) or IS (BOSS) registry between 2012 and 2014 within 24 h of onset were analyzed. In this prospective observational study, we identified 1,522 IS cases with adequate electrocardiographic evaluations to assess QTd after the index stroke. Patients were classified into four groups based on the quartile of QTd, with the lowest group as the reference. The primary stroke outcome was defined as a modified Rankin Scale score ≥3 at 1-year. Multiple logistic regressions were utilized to investigate the association between QTd and outcome events.Results: The mean QTd across all cases was 57 ms (40–83). Functional dependency or death was documented in 214 (14.98%) cases at 1 year. After adjusting for confounders, the prevalence of death and major disability (mRS ≥ 3) showed significant differences according to the quartile of QTd, with the risk of death and major disability (mRS ≥ 3) at 1 year being significantly higher for patients in Q4 than for those in Q1 (adjusted OR = 1.626, 95% CI:1.033–2.560). However, there were no significant correlation between QTd and the event outcomes at 1 year.Conclusions: QTd was associated with poor functional outcomes at 1 year. QTd is a useful surrogate marker for adverse functional prognosis, which might help to stratify risk in patients with acute IS.
Evaluation of Changes in Preoperative Cortical Excitability by Navigated Transcranial Magnetic Stimulation in Patients With Brain Tumor
Authors: Neville Iuri Santana , Gomes dos Santos Alexandra , Almeida Cesar Cimonari , Hayashi Cintya Yukie , Solla Davi Jorge Fontoura , Galhardoni Ricardo , de Andrade Daniel Ciampi , Brunoni Andre Russowsky , Teixeira Manoel Jacobsen , Paiva Wellingson Silva 
Published: January 2021

Background: This prospective study aimed to evaluate the cortical excitability (CE) of patients with brain tumors surrounding or directly involving the corticospinal tract (CST) using navigated transcranial magnetic stimulation (nTMS).Methods: We recruited 40 patients with a single brain tumor surrounding or directly involving the CST as well as 82 age- and sex-matched healthy controls. The patients underwent standard nTMS and CE evaluations. Single and paired pulses were applied to the primary motor area (M1) of both affected and unaffected cerebral hemispheres 1 week before surgery. The CE parameters included resting motor threshold (RMT), motor evoked potential (MEP) ratio for 140 and 120% stimulus (MEP 140/120 ratio), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF). Motor outcome was evaluated on hospital discharge and on 30-day and 90-day postoperative follow-up.Results: In the affected hemispheres of patients, SICI and ICF were significantly higher than in the unaffected hemispheres (p=0.002 and p=0.009, respectively). The 140/120 MEP ratio of patients' unaffected hemispheres was lower than that in controls (p=0.001). Patients with glioblastomas (GBM) had a higher interhemispheric RMT ratio than patients with grade II and III gliomas (p = 0.018). A weak correlation was observed among the RMT ratio and the preoperative motor score (R2 = 0.118, p = 0.017) and the 90-day follow-up (R2 = 0.227, p = 0.016).Conclusion: Using preoperative nTMS, we found that brain hemispheres affected by tumors had abnormal CE and that patients with GBM had a distinct pattern of CE. These findings suggest that tumor biological behavior might play a role in CE changes.
Quantifying a Learning Curve for Video Head Impulse Test: Pitfalls and Pearls
Authors: Korda Athanasia , Sauter Thomas C. , Caversaccio Marco Domenico , Mantokoudis Georgios 
Published: January 2021

Objective: The video head impulse test (vHIT) is nowadays a fast and objective method to measure vestibular function. However, its usability is controversial and often considered as a test performed by experts only. We sought to study the learning curve of novices and to document all possible mistakes and pitfalls in the process of learning.Methods: In a prospective cohort observational study, we included 10 novices. We tested their ability to perform correctly horizontal head impulses recorded with vHIT. We assessed vHITs in 10 sessions with 20 impulses per session giving a video instruction after the first session (S1) and individual feedback from an expert for session 2 (S2) up to session 10 (S10). We compared VOR gain, the HIT acceptance rate by the device algorithm, mean head velocity, acceleration, excursion, and overshoot between sessions.Results: A satisfying number of accepted HITs (80%) was reached after an experience of 160 vHITs. Mean head velocity between sessions was always in accepted limits. Head acceleration was too low at the beginning (S1) but improved significantly after the video instruction (p = 0.001). Mean head excursion and overshoot showed a significant improvement after 200 head impulses (p &lt; 0.001 each).Conclusions: We showed that novices can learn to perform head impulses invHIT very fast provided that they receive instructions and feedback from an experienced examiner. Video instructions alone were not sufficient. The most common pitfall was a low head acceleration.