bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression education fotonovela for engagement of Hispanic patients in treatment: a randomized clinical trial
Authors: Sanchez Katherine , Eghaneyan Brittany H. , Killian Michael O. , Cabassa Leopoldo J. , Trivedi Madhukar H. 
Published: December 2021

Abstract
Background
We report the primary outcomes from a randomized clinical trial testing a novel culturally-adapted patient education intervention to increase engagement of Hispanic patients in depression treatment. The Depression Education Fotonovela (DEF), Secret Feelings, incorporates popular images, cultural norms, and vivid pictures embedded within a soap opera narrative to increase depression knowledge and dispel myths about treatment. We then assessed engagement in a integrated care treatment model in response to the education intervention and subsequent changes in depression symptoms in a large community-based clinic whose patient population is majority Hispanic.

Method
The sample included 150 adult Hispanic patients with a confirmed diagnosis of depression who were randomly assigned to either: [1] integrated care + fotonovela; or [2] integrated care + standard education. Differences between treatment groups were examined as were changes in depression, anxiety, depression knowledge, and stigma scores over time and engagement in treatment.

Results
Results indicated that while depression scores significantly decreased over time for participants (F [2.811, 416.054] = 197.69, p < .001, η2 = .572), no differences between the two education groups were found (F [1, 148] = 0.70, p = .403, η2 = .005). At 12-month follow-up, 101 patients (80.8%) reported a 50% of greater reduction in depression scores from baseline.

Conclusions
We found little difference between the two education groups, suggesting that either may helpful for engaging Hispanic patients into care. Better tailoring of patient education, with the fotonovela or similarly adapted tools, will require more directly addressing the stigma associated with antidepressant medication.

Trial registration
The study was registered with www.clinicaltrials.gov: NCT02702596, on 03/20/2016. Retrospectively registered.
Capture - recapture based study on the completeness of smear positive pulmonary tuberculosis reporting in southwest Iran during 2016
Authors: Amiri Homayoun , Mohammadi Mohammad Javad , Alavi Seyed Mohammad , Salmanzadeh Shokrolah , Hematnia Fatemeh , Azar Mahnaz , Rahmatiasl Heydar 
Published: December 2021

Abstract
Background
Tuberculosis (TB) is one of the ten leading causes of death in infectious diseases and one of the ten leading causes of death in the world. For any TB control program, a valid surveillance is essential. In order to assess the status of the assessment, the quality of the record and the completeness of reporting should be assessed. The purpose of this study was to investigate the completeness of smear positive pulmonary tuberculosis reporting in Ahvaz, south west of Iran.

Methods
This cross-sectional study was conducted in 2016 in Ahvaz, southwest Iran. The study was conducted through a three-source Capture recapture method by collecting laboratory, hospital, physician prescription data; including patient referral to the health care center, prescriptions of patients receiving anti-tuberculosis drugs and prescriptions of medical TB diagnostic laboratories, and laboratory prescriptions. Percentage, mean and standard deviation were used to describe the variables. Data analysis was performed using log-linear model in Rcapture package R software.

Results
Generally, 134 new cases of smear-positive pulmonary tuberculosis patients were reported through three sources from urban and rural regions during 2016. Pulmonary tuberculosis was reported through three sources from urban and rural regions during 2016. The most common age group was 25 to 44 years and 79.1% of the patient were man. The overall prevalence of new cases of smear-positive pulmonary tuberculosis was in persons that lived urban areas (97.8%). The completeness of reporting the disease estimated by log-linear model was 87.5% and the incidence rate was estimated to be 11.8 disease per 100,000 persons. Completeness of reporting of laboratory, hospital and physician resources were 79%, 30% and 16.3%, respectively.

Conclusions
The present study shows the necessity of evaluating the quality, completeness and linkage between data. Linking between data sources can improve the accuracy and completeness of TB surveillance.
Staged transverse preputial island flap urethroplasty for some proximal hypospadias with moderate-to-severe chordee
Authors: Lin Hai , Wang Yu-Yun , Li Shi-Bing , Chen Ze-Ting , Su Liang-Ju 
Published: December 2021

Abstract
Background
We aimed to assess the outcome of staged transverse preputial island flap (TPIF) urethroplasty for repairing certain cases of primary proximal hypospadias with moderate-to-severe chordee in children.

Methods
Nighty-two consecutive boys who underwent either one-stage or staged TPIF urethroplasty for the repair of proximal hypospadias with moderate-to-severe chordee between August 2015 and December 2019 were evaluated retrospectively. Patients were divided into two groups: one-stage TPIF urethroplasty group (n = 44) and staged TPIF urethroplasty group (n = 48). We noted and compared the postoperative complications, including urethrocutaneous fistula, urethral diverticula, residual penile curvature, and urethral stricture in both groups.

Results
Both groups were followed up for 1–5 years, with an average of 3 years. No cases of residual or recurrence of penile chordee were reported in either group. In Group A, 9 patients (9/44, 20.4%) had postoperative urethrocutaneous fistula, and all patients underwent urinary fistula repair or urethroplasty. In Group B, postoperative urethrocutaneous fistula occurred in 2 cases (2/48, 4.1%), and one patient developed a urethrocutaneous fistula after the first operation, which was successfully repaired during the second operation. A urethrocutaneous fistula occurred in 1 case after completion of the second-stage operation; urethral fistula repair was performed successfully 6 months later. There were 2 cases of urethral stricture in Group A (2/44, 4.5%) and none in Group B. There were 6 cases of urethral diverticulum in Group A (6/44, 13.6%) and no cases of urethral diverticulum in Group B. The operative success rates were 61.3% and 95.8% in Group A and Group B, respectively (P < 0.001).

Conclusions
Compared with one-stage TPIF urethroplasty, staged TPIF urethroplasty in the treatment of certain cases of primary proximal hypospadias with moderate-to-severe chordee resulted in fewer postoperative fistulas, urethral strictures and urethral diverticula. The staged TPIF urethroplasty procedure was effective in reducing the operation difficulty and complication rate of hypospadias, improving the curative effect of complex hypospadias and having good clinical application value.
Social processes in academic-community partnership in health care. A grounded theory study
Authors: Pusa Susanna , Lind Susanne , Häggström Marie 
Published: December 2021

AbstractBackgroundInternational and national guidelines state that palliative care should be offered to everyone who needs it. To promote the implementation of palliative care in nursing homes, a partnership collaboration was initiated with the goal of implementing high quality palliative care. The partnership consisted of three partner groups: a project group from a non-profit organisation providing health care, managers at the nursing homes and an academic partner. The aim was to explore the social processes within academic-community partnership in a collaboration project.MethodsDigital focus group discussions were conducted with 16 participants, representing all three partner groups. One individual digital interview was also carried out. A constructivist perspective of a grounded theory approach was used for data analysis.ResultsThe core category, partnership positioning, covers the social processes of the academic-community partnership in a collaboration project to implement and evaluate health-promoting interventions in clinical health care. The core category was found to have four categories: Pre-positioning, Co-positioning, Re-positioning and GoOn-positioning. The process of partnership positioning is conceptualised in a model.ConclusionsOur findings indicate that a new partnership in an implementation project needs holistic, systemic thinking. To enhance implementation in a collaborative project involving different professionals and actors a plan is required to facilitate positioning activities. The process, the roles and the components need to be clearly defined and documented, and the management of a system requires knowledge of the interrelationships between all the components within the system. The development of a conceptual model of Partnership Positioning contributes to knowledge concerning the social dynamic processes which can be applied to support future academic-community collaboration and/or implementation projects.Trial registrationNot applicable. The present study has not been considered as a clinical trial.
Poly (N-vinylpyrrolidone) modification mitigates plasma protein corona formation on phosphomolybdate-based nanoparticles
Authors: Yu Youyi , Ghalandari Behafarid , Shen Guangxia , Wang Liping , Liu Xiao , Wang Aiting , Li Sijie , Xie Haiyang , Ding Xianting 
Published: December 2021

AbstractPhosphomolybdate-based nanoparticles (PMo12-based NPs) have been commonly applied in nanomedicine. However, upon contact with biofluids, proteins are quickly adsorbed onto the NPs surface to form a protein corona, which induces the opsonization and facilitates the rapid clearance of the NPs by macrophage uptake. Herein, we introduce a family of structurally homologous PMo12-based NPs (CDS-PMo12@PVPx(x = 0 ~ 1) NPs) capping diverse content of zwitterionic polymer poly (N-vinylpyrrolidone) (PVP) to regulate the protein corona formation on PMo12-based NPs. The fluorescence quenching data indicate that the introduction of PVP effectively reduces the number of binding sites of proteins on PMo12-based NPs. Molecular docking simulations results show that the contact surface area and binding energy of proteins to CDS-PMo12@PVP1 NPs are smaller than the CDS-PMo12@PVP0 NPs. The liquid chromatography-tandem mass spectrometry (LC–MS/MS) is further applied to analyze and quantify the compositions of the human plasma corona formation on CDS-PMo12@PVPx(x = 0 ~ 1) NPs. The number of plasma protein groups adsorption on CDS-PMo12@PVP1 NPs, compared to CDS-PMo12@PVP0 NPs, decreases from 372 to 271. In addition, 76 differentially adsorption proteins are identified between CDS-PMo12@PVP0 and CDS-PMo12@PVP1 NPs, in which apolipoprotein is up-regulated in CDS-PMo12@PVP1 NPs. The apolipoprotein adsorption onto the NPs is proposed to have dysoponic activity and enhance the circulation time of NPs. Our findings demonstrate that PVP grafting on PMo12-based NPs is a promising strategy to improve the anti-biofouling property for PMo12-based nanodrug design.
Graphical Abstract
Dynamics of a new stage-structured population model with transient and nontransient impulsive effects in a polluted environment
Authors: Quan Qi , Tang Wenyan , Jiao Jianjun , Wang Yuan 
Published: December 2021

AbstractIn this paper, we consider a new stage-structured population model with transient and nontransient impulsive effects in a polluted environment. By using the theories of impulsive differential equations, we obtain the globally asymptotically stable condition of a population-extinction solution; we also present the permanent condition for the investigated system. The results indicate that the nontransient and transient impulsive harvesting rate play important roles in system permanence. Finally, numerical analyses are carried out to illustrate the results. Our results provide effective methods for biological resource management in a polluted environment.
TREATMENT OF A COMBINATION OF DIABETIC POLYNEUROPATHY WITH TYPE 2 DIABETES AND GOUT
Authors: Tokareva S. , Kupeev R. , Hadarcev Aleksandr , Belyaeva Sof'ya 
Published: December 2021

The purpose of the work. To show the expediency of using a complex DPN therapy with thio-gammoy-600 in combination with TPP, B12-ankerman and febuxostat. Materials and research methods. The study involved 28 male patients suffering from DM2 aged 56-77 years, with an av-erage age of 64.6±0.7 years. The initial values of average fasting blood glucose were 7.8 ± 1.52 mmol/l, glycosylated hemoglobin 7.4 ± 0.13%. Two groups were identified: group 1 (main) – 14 people and group 2 (control) - 16 people. In group 2, basic DPN therapy was used (thiogamma 600 mg/day for 4 months). For the first 14 days, the drug was administered intravenously, and then administered orally. In group 1, in addition to basic DPN therapy, B12-ankerman and febuxostat (adenuric) – 80 mg/day were received. TPP was carried out on a portable device TPP-03 for 15 minutes daily. This treatment regimen was used for 4 months. The assessment of the quality of life (QL) was carried out using the MOS SF-36 questionnaire.
Results and their discussion. Four months after the start of therapy, more pronounced changes were observed in patients of the first group. The total score of the NSS scale in this group increased by 28.9%, and in group 2 - by 18.8%. The positive effect of therapy with adenuric and TES on the course of DPN shows that the use of this treatment will naturally lead to an improve-ment in the quality of life of patients, the dynamics of which was studied according to the results of the SF-36 questionnaire.
Anxiety, Depression and Anger: Application
of a Bifactor Model to Identify Common Symptoms
Authors: Garcia-Batista Zoilo Emilio , Guerra-Peña Kiero , Flores-Kanter Pablo Ezequiel , Moretti Luciana Sofía , Medrano Leonardo 
Published: December 2021

Aim of the studyAnger manifestations, depression and anxiety are strongly related to individual´s discomfort and well-being. The aim of the present study is to investigate the fit of a bifactor model applied on emotional disposition measures emphasizing the specification of a general factor through the identification of specific responses or indicators that can account for the communality between depression, anxiety and anger.Subject or material and methodsOne thousand and thirty-four participants from Dominican Republic took part in the study. They were selected by an accidental non-probabilistic sampling procedure. The ages of the participants were between 18 and 80 years old (Mean = 30.85, Standard Deviation = 15.39). Regarding gender, 45.9% (n = 374) were male and 54.1% (n = 441) female.ResultsThe results obtained show two large groups of indicators that would be common in these affective disposition types: affective and cognitive responses.DiscussionOn the one hand, affective responses include agitation, irritability, and tension or nervousness.ConclusionsOn the other hand, cognitive symptoms are linked to the presence of repetitive worrying and uncontrollable thoughts. In this way, it is possible to identify a general stress response in this group of indicators.
Like Me, Like My Psychiatry: How Psychiatrists present their professional identities on Instagram
Authors: ayribas basar 
Published: December 2021

Aim of the studySocial media platforms like Instagram gained a popularity for healthcare professionals to reach potential clients and patients. This study aims to reveal the nature of Instagram use of psychiatrists in Turkey.Subject or material and methodsInstagram search function for hashtags and username was used to find psychiatrists who use public accounts. A search between 15.10.2020 – 15.11.2020 were conducted with keywords psikiyatri and psikiyatrist (Turkish words for psychiatry and psychiatrists). A total number of 241 accounts from physicians were reached and after exclusion criteria 124 accounts are included in the study and 30758 total posts were analyzed. Descriptive parameters of the accounts and contents of the shared posts are analyzed and classified further.Results52.4% of all psychiatrists were from one of the seven regions of Turkey and 40.3% of all accounts based in one city, Istanbul. Most of the users had a title of specialists (78.2%) and worked predominantly in private practices (66.9%). Almost half of the sample has explicitly stated to offer online therapy option and 10.5% of all accounts posted patient info. Sex therapy was the most common area of specification, followed by couples & family therapy, EMDR and CBT.DiscussionInstagram use patterns of psychiatrist from Turkey reveal important insights between socioeconomic factors and psychiatry practice. Our findings reveal that Instagram helps colleagues to reach public and to adjust their practice according to the feedbacks from Instagram community.ConclusionsInstagram has created a unique type of psychiatry practice regarding type of specifications of psychiatrists.
Challenges and difficulties students face during COVID-19 pandemic. Insights from the survey among students of Medical Faculty of Jagiellonian University in Cracow – qualitative data presentation
Authors: Taurogiński Bartłomiej , Chrobak Adrian , Józefik Barbara 
Published: December 2021

Aim of the studyPandemic outbreak of Coronavirus Disease 2019 (COVID-19) had significant impact on medical education across Europe. Due to the lockdown-type control measures Universities were forced to adapt to new conditions by unexpectedly switching to on-line teaching. The aim of the study was to explore medical students’ needs, problems, expectations, views on positive aspects of current situation, and attitudes toward on-line teaching, and academic administration during early stages of lock-down.Subject or material and methodsInvestigators created an online survey which received 289 students responses. Survey contained quantitative and qualitative questions. Qualitative data was analyzed using Consensual Qualitative Research (CQR) methodology.Results20.76% participants responded they needed assistance or help, 49.83% of students reported that situation worsened their studying conditions, 57.79% requested more interest from University administration in current situation, 5% of the students reported being deprived of social support. Following categories has been extracted from qualitative data: struggles students face during pandemic, worries and concerns students report, positive aspects of current situation, students’ hopes and expectancies, on-line classes opinions. Frequencies of most common answers within abovementioned categories were calculated.Discussion-ConclusionsTo our best knowledge this is the first study presenting complex quantitative and qualitative evaluation of medical students’ situation during COVID-19 pandemic outbreak. According to the acquired data, students faced an anxiety and stress provoking situation that required undertaking special measures. This data is useful in gaining insight into students’ experiences of pandemic and may help as a guidance for planning intervention.
Simulation of reconfigurable double-input optical gates based on a microring flower-like structure, part II. Combinational logic gates
Authors: Seifi Laleh Mohammad , Razaghi Mohammad 
Published: December 2021

A microring flower-like architecture is introduced to obtain optical logic gates that can be reconfigured. The proposed design can operate as a time-division multiplexer, a half adder/subtractor, and an optical single bit comparator circuit. The optical pump pulses modulate the microring resonators in this arrangement. Green lasers with a resonant wavelength of 532 nm are used to generate the optical pump pulses. To theoretically analyze the structure, the signal flow graph approach is applied. The proposed structure’s performance is investigated by calculating certain figures of merit for the resulting output data streams. Outputs of the presented combinational logic gates are optimized by designing the most proper geometry of flower-like structure and simultaneously by opting for the best input port to drop port’s optical path. It is demonstrated that proper distinguishing between 0 and 1 levels occurs in the output. The compact structure proposed is simple, expandable, and reconfigurable. The proposed structure can be used as a key component in high-speed optical networks, according to simulation results.
Disease progression in patients with the restrictive and mixed phenotype of Chronic Lung Allograft dysfunction—A retrospective analysis in five European centers to assess the feasibility of a therapeutic trial
Authors: Gottlieb Jens , Verleden Geert M. , Perchl Michael , Valtin Christina , Vallee Alexander , Brugière Olivier , Bravo Carlos 
Published: December 2021

BackgroundChronic Lung Allograft Dysfunction (CLAD) is a major obstacle for long term survival after lung transplantation (LTx). Besides Bronchiolitis Obliterans Syndrome, two other phenotypes of CLAD, restrictive allograft syndrome (RAS) and mixed phenotype, have been described. Trials to test in these conditions are desperately needed and analyzing natural outcome to plan such trials is essential.MethodsWe performed a retrospective analysis of functional outcome in bilateral LTx recipients with RAS and mixed phenotype, transplanted between 2009 and 2018 in five large European centers with follow- up spirometry up to 12 months after diagnosis. Based on these data, sample size and power calculations for randomized therapeutic trial was estimated using two imputation methods for missing values.ResultsSeventy patients were included (39 RAS and 31 mixed phenotype), median 3.1 years after LTx when CLAD was diagnosed. Eight, 13 and 25 patients died within 6, 9 and 12 months after diagnosis and a two patients underwent re-transplantation within 12 months leading to a graft survival of 89, 79 and 61% six, nine and 12 months after diagnosis, respectively. Observed FEV1decline was 451 ml at 6 months and stabilized at 9 and 12 months, while FVC showed continuous decline. Using two methods of imputation, a progressive further decline after 6 months for FEV1 was noted.ConclusionThe poor outcome of these two specific CLAD phenotypes suggests the urgent need for future therapeutic randomized trials. The number of missing values in a potential trial seems to be high and most frequently attributed to death. Survival may be used as an endpoint in clinical trials in these distinct phenotypes and imputation techniques are relevant if graft function is used as a surrogate of disease progression in future trials.