bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-House Preparation and Quality Control of Ac-225 Prostate-Specific Membrane Antigen-617 for the Targeted Alpha Therapy of Castration-Resistant Prostate Carcinoma
Authors: Thakral Parul , Simecek Jakub , Marx Sebastian , Kumari Jyotsna , Pant Vineet , Sen Ishita Barat 
Published: June 2021

Purpose:
Ac-225 labeled with prostate-specific membrane antigen (PSMA-617), a transmembrane glycoprotein which is highly expressed in prostate carcinoma cells, is presently being considered a promising agent of targeted alpha therapy for the treatment of patients suffering from metastatic castration-resistant prostate cancer. In the present study, we report an optimized protocol for the preparation of therapeutic dose of Ac-225 PSMA-617 with high yield and radiochemical purity (RCP).

Methods:
Ac-225 PSMA-617 was prepared by adding the peptidic precursor-PSMA-617 (molar ratios, Ac-225: PSMA-617 = 30:1) in 1 ml ascorbate buffer to Ac-225 and heating the reaction mixture at 90°C for 25 min to obtain the radiopeptide with high RCP and yield. The radiolabeled peptide was administered in patients who met the eligibility criteria and posttherapy assessment was done.

Results:
Ten batches of Ac-225 PSMA-617 were prepared following this protocol. The radiopeptide was obtained with an adequate yield of 85%–87% and RCP of 97%–99%.

Conclusion:
The current protocol allows single-step, successful, routine inhouse radiolabeling of Ac-225 with PSMA-617 with high yield and RCP.
Critical appraisal of journal article by psychiatry PG residents using a new module
Authors: Bhat Pookala Shivaram , Chail Amit , Srivastava Kalpana 
Published: June 2021

Background:
A gap exists from evidence-based medicine (EBM) to clinical practice and there is a felt need to bridge this. Critical appraisal of scientific articles during Journal club by postgraduate (PG) residents will help them to understand and apply the scientific evidence into best clinical practice. Hence, a new module of critical appraisal of journal articles was used for Psychiatry Residents in a Medical College and its impact was assessed.

Materials and Methods:
Nine psychiatry PG residents from three academic batches participated in the study after informed consent and Institutional ethical committee clearance. They were trained in the Colorado Psychiatry EBM Examination Test module. Subsequently, three consecutive journal article presentations of them were assessed under seven Subtests of the module.

Results:
There was gradual increase in the assessment scores of all PG residents with each journal article presentation. They also expressed satisfaction of the assessment method and felt confident of applying the principles of critical appraisal in their clinical practice in future.

Conclusion:
This study evaluated the impact of a new module of critical appraisal of journal article by psychiatry PG residents. It was found to be acceptable by residents and improved their competency to apply literature-based EBM into their clinical practice. It is recommended for further multicentric evaluation on a larger sample.
Psychiatric morbidity in patients with idiopathic Parkinson's disease
Authors: Kumar Santhosh , Avasthi Ajit , Modi Manish , Grover Sandeep 
Published: June 2021

Objective:
To evaluate the prevalence of psychiatric comorbidities in patients with idiopathic Parkinson's disease (IPD).

Methodology:
Two hundred and thirty-nine patients with IPD were evaluated on Mini-International Neuropsychiatric Interview PLUS (MINI-PLUS). In addition, patients found to have depression as per the MINI-PLUS were evaluated on Beck Depression Inventory.

Results:
One hundred and thirty-five (56.5%) patients had a current psychiatric diagnosis and 59.8% had a lifetime psychiatric diagnosis. As per MINI-PLUS, about two-fifth (39.7%) of patients had suicidality. In 18.8% of patients, suicidality was present in the absence of axis-I psychiatric diagnosis. Among the various psychiatric disorders, the most common disorders included depressive disorders (current: 17.5%; lifetime: 23.8%), anxiety disorders (current: 17.5%; lifetime: 17.5%), and psychotic disorders (current: 11.3%; lifetime: 11.7%).

Conclusions:
More than half of the patients with Parkinson's disease have psychiatric disorders. High prevalence of psychiatric morbidity calls for close liaison between the neurologist and the psychiatric disorders.
A Case of Extrapulmonary Tuberculosis Presenting as Multiple Pleural Nodules and Esophageal Ulcer
Authors: Chakkamadathil Jesin Kumar , Chetambath Ravindran , Shivashankaran Sanjeev , Girija C. , Mathew Christopher 
Published: June 2021

ABSTRACT
Tuberculosis (TB) can affect various organs besides the lungs. Among the extrapulmonary sites, pleura and gastrointestinal tract are the second- and sixth-most common sites, respectively. Pleural involvement usually occurs in the form of pleural effusion, and the sites most commonly involved in gastrointestinal TB are the peritoneum and ileocecal area. Here we present an interesting case of a 23-year-old female who presented to the gastroenterologist with symptoms of dysphagia, regurgitation of food, and weight loss. Esophagogastro duodenoscopy showed an esophageal ulcer which was confirmed to be due to TB. Incidentally, this patient also had multiple pleural nodules due to TB. This case is unique since there is a simultaneous occurrence of two different sites of occurrence of extrapulmonary TB.
Association of Pattern of Mandibular Invasion in MDCT with Recurrence in Oral Cancers
Authors: Thakker Vishal , Arora Manali , Thakkar Nisarg 
Published: June 2021

Background:
Mandibular invasion has been a long-debated criterion for predicting prognosis in oral cancers. Though the American Joint Committee on Cancer (AJCC) marks cortical erosion in oral lesions as T4 disease, it is often challenged that mere superficial bony erosion should not be used to demark T4 disease.

Aim:
This study aimed to evaluate the association of pattern of mandibular erosion in preoperative Multi-Detector CT (MDCT) of oral cancers with the presence of recurrent loco-regional malignant disease.

Materials and Methods:
A retrospective study was done in the Department of Radio-Diagnosis of a tertiary center in Western India. MDCT Neck findings in 56 consecutive postoperative patients clinically suspected for recurrent oral carcinoma over a period of 1 year were assessed. Preoperative MDCT of all patients was evaluated for presence and pattern of mandibular involvement by primary malignancy. These patterns were compared with the presence of recurrent disease in the postoperative scan. Association between two findings was tested by Fisher's exact test.

Results:
Forty-eight patients showed features of recurrent malignancy on MDCT confirmed by biopsy; of which 10 patients had shown no bony invasion in the preoperative scan, 14 had shown cortical erosion and 24 showed medullary invasion. P value for association of recurrence and bony invasion pattern was found to be 0.6705 (insignificant) for cortical erosive lesions and 0.0469 (significant) for medullary infiltrative lesions.

Conclusion:
Only medullary infiltrative lesions of the mandible have a statistically significant association with recurrent disease and may be used as a prognostic factor. Cortical erosions are statistically insignificant in predicting recurrence similar to no bone invasions.
Analysis of Fractal Dimension and Radiomorphometric Indices of Mandible on Panoramic Radiographs in End-Stage Renal Disease at a Tertiary Care Centre in South India
Authors: Redhu Anju , Suman B. 
Published: June 2021

Background and Objectives:
Chronic kidney disease (CKD), especially, end-stage renal disease (ESRD), is associated with endocrinal and metabolic alterations that negatively affect the skeletal system, and can result in renal osteodystrophy (ROD) and secondary osteoporosis. These changes can affect the mandibular density and thus can be reflected in mandible on panoramic radiographs (PR), which are frequently assessed by oral physicians. This study attempted to evaluate these mandibular skeletal alterations using radiomorphometric indices (RI) and fractal dimension (FD) analysis, in patients with ESRD, thereby aiding in their appropriate management for the dental treatment.

Material and Methods:
Retrospective data (including digital PRs) of 30 patients with CKD (ESRD) who were above 18 years of age were retrieved and 30 age and sex-matched healthy individuals having met the selection criteria were selected. Digital PR were used to assess the mandibular cortical index (MCI), mental index (MI), panoramic mandibular index (PMI), and FD by using ImageJ program.

Results:
No statistically significant difference was noted among the study groups and controls for the mean values of PMI, FD, and distribution of MCI category (P > 0.05). However, the mean value of MI was significantly reduced among the kidney patients as compared to the controls (P < 0.05). No significant correlation was noted between duration of diseases, RI (MCI, MI, PMI) and FD.

Conclusion:
MI values of patients with ESRD were found to be lower than those in control subjects. This finding suggests that MI analysis might be a promising, simple, and cost-effective tool for evaluating cortical bone structure in this high-risk population and any signs of osteoporosis could be withheld at the earliest stage with a prompt referral.
Comparative Evaluation of the Efficacy of Gabapentin and Gabapentin in Combination with Nortriptyline in the Management of Pain-Related Temporomandibular Disorders
Authors: Tak Mohsin Muzaffar , Chalkoo Altaf Hussain , Bhat Tariq Ahmad , Jan Tauseefa 
Published: June 2021

Background:
Temporomandibular disorders (TMDs) are considered the most common orofacial pain conditions of nonodontogenic origin. The current perspective regarding TMD is multidimensional. If the pain becomes chronic, it can have a great impact on the social and emotional behavior of the patient.

Materials and Methods:
A total of 40 patients between the age groups of 18 and 45 years were included in the study. These patients were divided into two groups comprising 20 patients each. Group I was prescribed gabapentin and was advised to take the medicine twice daily. Group II was prescribed gabapentin along with nortryptyline twice daily. Patients in each group were evaluated at the end of every week using a visual analog scale (VAS) score for pain, maximum interincisal mouth opening, and several muscle tenderness sites for 3 weeks, and a comparison was made.

Results:
The age range in group I was 19–45 years, whereas in group II it was 18–45 years with a P value of 0.711. Female predominance was observed in both groups as 65% of patients were females in group I and 60% were females in group II and P value obtained was 0.74. VAS score decreased more rapidly in group II than group I. The P value obtained was <0.001 at the end of the third week. Comfortable moth opening shows a more effective increase in group II than group I. The P value (0.003) shows significance at the end of the third week. The mean number of muscle tenderness sites at the end of 3 weeks in group I and group II reduced to 1.15 and 0.40, respectively.

Conclusion:
The combination therapy of gabapentin with nortryptyline was found to be more effective than gabapentin alone.
Effect of mobile voice calls on treatment initiation among patients diagnosed with tuberculosis in a tertiary care hospital of Puducherry
Authors: Majella MG , Thekkur P , Kumar AM , Chinnakali P , Saka VK , Roy G 
Published: June 2021

Objective:
In India, about one third of tuberculosis (TB) patients diagnosed at tertiary hospitals are missed during a referral to peripheral health institutes for treatment. To address this, we assessed whether mobile voice call reminders to TB patients after diagnosis at a tertiary hospital decrease the proportion of “pretreatment loss to follow-up” (PTLFU), compared with the conventional paper-based referral.

Design:
A two-group parallel-arm randomized controlled trial was conducted.

Setting:
The study was conducted in a tertiary care hospital at Puducherry, South India.

Participants:
All newly diagnosed TB patients, both pulmonary and extrapulmonary, who were referred for treatment from the selected tertiary care hospital and possessed a mobile phone were eligible to participate. The participants were enrolled between March 2015 and June 2016 and were randomized to study groups using the block randomization with allocation concealment.

Intervention:
The participants in the intervention arm received standardized mobile voice calls reminding them to register for anti-TB treatment on the second and seventh day after referral in addition to the conventional paper-based referral received by the control group.

Primary outcomes:
Patients not started on anti-TB treatment within 14 days of referral were considered as PTLFU. The outcome of PTLFU was ascertained through phone calls made on the 14th day after referral. The intention-to-treat analysis was used, and the proportion of PTLFU in the study groups and the risk difference with 95% confidence interval (CI) were calculated.

Results:
Of the 393 patients assessed for eligibility, 310 were randomized to the intervention (n = 155) and control (n = 155) arms. In the intervention arm, 14 (9%) out of 155 were PTLFU compared with 28 (18%) of the 155 patients in the control arm. The absolute risk difference was 9% (95% CI [1.5, 16.6], P = 0.01).

Conclusion:
Mobile voice call reminder to patients is a feasible intervention and can reduce PTLFU among referred TB patients.
Heavy Metal Loading in Surface Sediments along the Kawere Stream, Tarkwa, Ghana
Authors: Ndur S. A. , Nyarko S. Y. , Quaicoe I. , Osei L. B. 
Published: June 2021

Sediment contamination by heavy metals resulting from anthropogenic activities is increasingly becoming a global concern due to the risk it poses to human well-being and ecological integrity at large. The purpose of this study was to assess the heavy metals loading in sediment along the Kawere stream. Ten sediment samples were collected, acid digested and analysed for copper (Cu), lead (Pb), cadmium (Cd), manganese (Mn), zinc (Zn), nickel (Ni), chromium (Cr), cobalt (Co) and iron (Fe) using a Varian AA240FS Atomic Absorption Spectrometer (AAS). The Australian and New Zealand Environment and Conservation Council (ANZECC) guidelines for freshwater sediment quality was used as the benchmark against which the measured metal concentrations were compared. Nemerow’s pollution and potential ecological risk indices were used to evaluate the pollution status and ecological risk levels of the heavy metals in the stream. The results obtained indicated that, except Cu which exceeded the ANZECC trigger value of 65 mg/kg at three sampling sites (K01=171.29 mg/kg, K05=170.83 mg/kg and K07=113.31 mg/kg), all other measured heavy metals concentrations were below their corresponding ANZECC values. Heavy metal pollution assessment showed that three samples (K01, K05 and K07) were slightly polluted, suggesting the likelihood of posing a health threat to the aquatic organisms and humans. Calculated Ecological Risk Index (RI) ranged from 3.229 to 19.750 (RI < 150), representing a low ecological risk. As such, the metals, Cu, Ni, Cd, Pb, Cr, and Zn pose a low ecological risk to the aquatic ecosystem. Although the ecological risk is low based on the current results, constant monitoring of the stream quality is recommended due to the increasing human activities along the stream as well as the sediments ability to accumulate and remobilise heavy metals back into the water column and possibly transferring them through the food chain.

Keywords: Heavy Metals, Sediment, Ecological Risk Assessment, Pollution, Stream
Dimensions of User Experience - from the Product Design Perspective
Authors: Bongard-Blanchy Kerstin , Bouchard Carole 
Published: June 2021

The UX domain has so far been strongly associated with software development. However, its methods are finding their way intodomains like Product and Service Design. Product Designers now need competencies far beyond classical form-giving. The objective of thispaper is to show Product Designers which design dimensions they need to attend to when designing for UX. The paper gives an overview ofdesign dimensions that potentially impact how users’ experience products. These dimensions are brought together from theories ofCognitive Science, models of Human-Computer Interaction and findings from Design Research. They are presented under four categories:dimensions of human perception, dimensions of products, dimensions of the context of use and the temporal dimension. In the final part, theidentified dimensions are connected into a schema, illustrating their interplay and therefore the journey of UX between a user and a product,in a certain context over a certain time.
Le domaine EU (Expérience Utilisateur) a été étroitement lié au développement des logiciels. Les méthodes UX trouventcependant de plus en plus d’applications dans le Design de Produits. Aujourd’hui le Designer Produit doit mettre en oeuvre des compétencesqui vont bien au-delà de la seule définition de l’apparence. L’objet de cet article est de mettre en lumière ces dimensions du design que lesDesigners Produit soucieux de concevoir dans le respect de l’UX ne sauraient ignorer. L’article apporte ainsi une vue globale sur lesdimensions susceptibles d’impacter l’UX. L’identification des dimensions pertinentes puise à la fois dans les théories de la psychologiecognitive, dans les modèles d’interaction homme-machine, ainsi que dans les résultats de la recherche en design. Ces dimensions sontensuite regroupées sous quatre catégories : les dimensions de la perception humaine, du produit et du contexte de l’utilisation, ainsi que ladimension temporelle. Enfin, ces dimensions sont mises en relation dans un schéma qui illustre le cours de l’expérience entre un utilisateuret un produit, dans un contexte et avec sa temporalité.
Manajemen Emosi di Masa Pandemi
Authors: Jatmiko Bakhoh , Kawengian Sherly Ester E. , Kapoyos Kapoyos 
Published: June 2021

Pandemi Covid-19 telah menggoncang peradaban manusia di abad ini. Hampir semua sektor kehidupan terdampak dan nyaris dilumpuhkan olehnya. Tak pelak, pandemi ini menghadirkan berbagai persoalan-persoalan kehidupan yang serius, termasuk bagi kejiwaan manusia. Berbagai riset yang telah dilakukan menemukan bahwa tingkat stres dan gangguan kejiwaan meningkat di masa pandemi ini. Oleh karena itu, kajian ini dilakukan untuk menemukan prinsip Alkitabiah tentang pengelolaan emosi yang diakibatkan oleh situasi sulit ini. Penulisan ini menggunakan metode kualitatif dengan pendekatan deskreptif yang berfokus pada kajian tektual dari Mazmur 56. Penulisan juga dilakukan dengan menggunakan berbagai literatur dan dokumen serta data pendukung. Kajian di dalam artikel ini menemukan bahwa persoalan emosi yang meningkat dapat diatasi ketika prinsip manajemen emosi yang dilakukan Daud juga diterapkan oleh orang percaya. Di dalam pengalaman bergumul emosi negatif sebagai respon terhadap dituasi yang dihadapi, orang percaya perlu mengembangkan sikap jujur terhadap apa yang dirasakan, mengubah perspektif terhadap kesulitan dan mengembangkan sikap positif.
Factors affecting academic self-efficacy and learning experiences of pharmacy students: Insights from a qualitative study in Zambia
Authors: Kalungia Aubrey Chichonyi , Chigunta Micheal , Sichone James , Apampa Bugewa , Marshall Sarah , May Claire , Mulundu Georgina , Mwila Chiluba , Banda Sekelani Stanley 
Published: June 2021

Background: Factors influencing how pharmacy students learn and experience pharmaceutical education have not been elucidated in Zambia. Aim: To elucidate contextual factors affecting academic self-efficacy and learning experiences among undergraduate pharmacy students at a public university in Zambia. Methods: A qualitative study utilising focus group discussions was conducted at the University of Zambia. Thirty-two undergraduate pharmacy students participated in four focus group discussions. Qualitative data were thematically analysed. Results: Four themes and eight sub-themes emerged from the data. Notional time management, learning style, and motivation; educational programme-related factors such as course load, the pace of teaching; the learning environment; and assessment practices affected undergraduate pharmacy students’ self-efficacy and learning experiences. Conclusion: Addressing the student-related, educational programme-related, and the learning environment factors identified in this study will contribute to the improvement of undergraduate pharmacy students’ learning experiences. This is premised to improve their educational outcomes and future practice of pharmaceutical care.
KHAKIMKHAN TURYA – FERGANA PERIOD OF APPLICANT FOR KASHGAR (end of XIX century)
Authors: Asanova Svetlana 
Published: June 2021

Мақолада Яқуббек Бадавлат вафотидан кейин Қошғарда ҳокимият учун даъвогарлик қилган, аммо мағлубиятга учраб, Фарғонага қочиб келган Хакимхон Тўранинг фаолияти ёритилган. Муаллиф архив ҳужжатлари ва мавжуд адабиётларга таянган ҳолда, Ҳакимхон рус ҳукмрон доираларининг Цин империяси билан муносабатларида сиёсий қўғирчоққа айланганлигини кўрсатади.
Pengetahuan dan Sikap Wanita Pekerja Seks (WPS) dalam Upaya Penanggulangan HIV/AIDS dengan Persuasi Penggunaan Kondom di Eks Lokalisasi Gempol Porong Kabupaten Banyuwangi Tahun 2019
Authors: Rachman Machria 
Published: June 2021

HIV (Human Immunodeficiency Virus) dan AIDS (Acquired Immunodeficiency Syndrome masih menjadi ancaman kesehatan masyarakat secara global. Prevalensi HIV/AIDS di Kabupaten Banyuwangi juga cukup tinggi yakni 4.557 kasus. Cara penularan HIV terbesar adalah melalui hubungan seksual (71 %). Sejumlah 18,23% orang dengan HIV/AIDS (ODHA) adalah wanita pekerja seks (WPS). Meskipun lokalisasi di Banyuwangi telah resmi ditutup pada tahun 2013, namun praktik prostitusi masih terselubung dijalankan. Hubungan seksual tanpa kondom menjadi mata rantai penyebaran HIV/AIDS di masyarakat. Tujuan penelitian ini adalah untuk mengetahui korelasi pengetahuan dan sikap WPS dengan persuasi penggunaan kondom di eks lokalisasi Gempol Porong Kabupaten Banyuwangi. Desain penelitian adalah analitik kuantitatif dengan menggunakan pendekatan cross sectional. Sampel penelitian yaitu WPS di Eks Lokalisasi Gempol Porong berjumlah 32 orang yang diambil dengan teknik Total sampling. Pengambilan data dengan metode angket dan dianalisis statistik menggunakan SPSS 20.0 version. Hasil penelitian menunjukkan bahwa WPS yang memiliki pengetahuan rendah dalam penanggulangan HIV/AIDS sebanyak 56,2 %, sikap negatif sebesar 53,1% dan sebanyak 59,4% tidak melakukan persuasi penggunaan kondom. Analisis uji chi-Square menunjukkan ada hubungan antara pengetahuan WPS dalam penanggulangan HIV/AIDS dengan persuasi penggunaan kondom (ρ = 0,002α), serta ada hubungan antara sikap WPS dalam upaya penanggulangan HIV/AIDS dengan persuasi penggunaan kondom (nilai ρ = 0,000α). Variabel yang berpengaruh terhadap penanggulangan HIV/AIDS dengan persuasi penggunaan kondom adalah sikap, dengan probabilitas sikap negatif WPS sebesar 78%. Penelitian ini diharapkan dapat memberikan masukan pihak terkait guna peningkatan 100% penggunaan kondom sehingga dapat menekan angka pertumbuhan HIV/AIDS di Kabupaten Banyuwangi.