bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropsychological deficits have only limited impact on psychological well-being in amyotrophic lateral sclerosis
Authors: Schrempf Till , Finsel Julia , Uttner Ingo , Ludolph Albert C. , Lulé Dorothée 
Published: July 2021

Abstract
Objective
To investigate the association between neuropsychological deficits and psychological well-being in amyotrophic lateral sclerosis (ALS).

Methods
Subjective (Schedule for the Evaluation of the Individual Quality of Life-Direct Weighting, SEIQoL-DW) and global quality of life (QoL; Anamnestic Comparative Self-Assessment, ACSA) as well as depression (ALS-Depression-Inventory, ADI-12) as indicators for psychological well-being were measured in 214 patients with ALS and correlated with neurocognitive performance assessed by the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Primary caregivers evaluated behaviour. Patients were classified to be cognitively (ALSci) or behaviourally impaired (ALSbi) according to Strong criteria.

Results
ALSbi patients had poorer psychological well-being than patients without behavioural alterations, while the psychological well-being of patients with and without neurocognitive deficits was comparable.

Conclusion
The study provides evidence that minor neuropsychological deficits do not interfere with psychological well-being of ALS in contrast to alterations on behavioural level. Thus, abnormalities in individual cognitive domains have limited relevance for the patients’ everyday life in comparison to the impact of behavioural alterations.
Automatic steel grades design for Jominy profile achievement through neural networks and genetic algorithms
Authors: Vannucci Marco , Colla Valentina 
Published: July 2021

AbstractThe paper proposes an approach to the design of the chemical composition of steel, which is based on neural networks and genetic algorithms and aims at achieving a desired hardenability behavior possibly matching other constraints related to the steel production. Hardenability is a mechanical feature of steel, which is extremely relevant for a wide range of steel applications and refers to the steel capability to improve its hardness following a heat treatment. In the proposed approach, a neural-network-based predictor of the so-called Jominy hardenability profile is exploited, and an optimization problem is formulated, where the optimization function allows taking into account both the desired accuracy in meeting the target Jominy profile and other constraint. The optimization is performed through genetic algorithms. Numerical results are presented and discussed, showing the efficiency of the proposed approach together with its flexibility and easy customization with respect to the user demands and production objectives.
The Moral Irrelevance of Constitutive Luck
Authors: Diamantis Mihailis E. 
Published: July 2021

AbstractOne’s constitution—whether one is generous or miserly, temperate or intemperate, kind or mean, etc.—is beyond one’s control in significant respects. Yet one’s constitution affects how one acts. And how one acts affects one’s moral standing. The counterintuitive inference—the so-called problem of constitutive moral luck—is that one’s moral standing is, to some significant extent, beyond one’s control. This article grants the premises but resists the inference. It argues that one’s constitution should have no net impact on one’s moral standing. While a bad constitution lowers the chance that one will act morally, it offers significant gains to moral standing should that chance materialize. A good constitution increases one’s chance of performing good acts but for correspondingly more modest gains. This effect should smooth out, and possibly eliminate, the expected impact of constitution on moral standing.
Reduced Models of Cardiomyocytes Excitability: Comparing Karma and FitzHugh–Nagumo
Authors: Gonzalez Herrero Maria Elena , Kuehn Christian , Tsaneva-Atanasova Krasimira 
Published: July 2021

AbstractSince Noble adapted in 1962 the model of Hodgkin and Huxley to fit Purkinje fibres, the refinement of models for cardiomyocytes has continued. Most of these models are high-dimensional systems of coupled equations so that the possible mathematical analysis is quite limited, even numerically. This has inspired the development of reduced, phenomenological models that preserve qualitatively the main feature of cardiomyocyte’s dynamics. In this paper, we present a systematic comparison of the dynamics between two notable low-dimensional models, the FitzHugh–Nagumo model (FitzHugh in Bull Math Biophys 17:257–269, 1955, J Gen Physiol 43:867–896, 1960, Biophys J 1:445–466, 1961) as a prototype of excitable behaviour and a polynomial version of the Karma model (Karma in Phys Rev Lett 71(7):16, 1993, Chaos 4:461, 1994) which is specifically developed to fit cardiomyocyte’s behaviour well. We start by introducing the models and considering their pure ODE versions. We analyse the ODEs employing the main ideas and steps used in the setting of geometric singular perturbation theory. Next, we turn to the spatially extended models, where we focus on travelling wave solutions in 1D. Finally, we perform numerical simulations of the 1D PDE Karma model varying model parameters in order to systematically investigate the impact on wave propagation velocity and shape. In summary, our study provides a reference regarding key similarities as well as key differences of the two models.
Practical interpretation of pressure tests of hydraulically fractured vertical wells with finite-conductivity in naturally fractured oil and gas formations
Authors: Jongkittinarukorn Kittiphong , Escobar Freddy Humberto , Ramirez Diana Manuela , Suescún-Díaz Daniel 
Published: July 2021

AbstractThis paper presents a well test interpretation methodology using characteristic points and lines found on the pressure and pressure derivative versus time log–log plot for the characterization of a finite-conductivity fractured vertical hydrocarbon well in a double-porosity (heterogeneous) formation considering a new and practical analytical Laplacian model which require less computational time and have more accuracy than semi-analytical models. Some existing equations are found to work well for the new model, and new expressions are developed. The accuracy of the developed equations is successfully tested with synthetical examples.
Succesvolle behandeling van IgG4-gerelateerde retroperitoneale fibrose met rituximab
Authors: van Maaren Lucas , Marcelissen Tom , Slot Marjan , Hermans Tom 
Published: July 2021

SamenvattingOntregelingen in het adaptieve en humorale immuunsysteem kunnen leiden tot IgG4-gerelateerde ziekte. Deze zeldzame ziekte kan zich manifesteren in verschillende organen, waaronder het retroperitoneum. Aldaar kan het aanleiding geven tot fibrose, met als voornaamste uitingen nierfunctiestoornissen door postrenale obstructie en/of pijnklachten. Naar aanleiding van twee casus beschrijven wij de klinische presentatie, diagnostiek en behandeling van dit ziektebeeld bij patiënten die na een eerdere behandeling met prednison succesvol werden behandeld met rituximab.
COVID-19 and women's nutrition security: panel data evidence from rural India
Authors: Gupta Soumya , Seth Payal , Abraham Mathew , Pingali Prabhu 
Published: July 2021

AbstractIn response to the COVID-19 pandemic, India implemented a stringent nationwide lockdown. Although food value chains and allied activities were exempted from the lockdown, there were widespread disruptions in food access and availability. Using two panel-datasets, we distinguish the pandemic's impact on non-staples versus staples in relation to household food availability and women’s diet diversity at the national, state, and district levels in four economically backward districts of Uttar Pradesh (Maharajganj), Bihar (Munger), and Odisha (Kandhamal and Kalahandi). Both the primary and secondary data indicate a decline in household food expenditures and women’s dietary diversity in May 2020 compared to May 2019, particularly for non-staples like meats, eggs, vegetables and fruits. This occurred despite special PDS, direct benefit transfer, and ration from aanganwadis rations reaching 80%, 50%, and 30% of surveyed households, respectively. While national and state-level expenditures recovered to the pre-lockdown levels by June 2020, the district-level expenditures did not recover. Our findings contribute to the growing body of evidence of women's disproportionate vulnerability to economic shocks, the impact of a staple grain focused safety net program, and restricted markets on the access and availability of diverse nutritious foods. This paper makes a case for policy reforms towards PDS diversification to include nutrition-rich foods and market reforms to remove supply-side bottlenecks and expansion of direct benefit transfers for healthy food access. We also highlight the importance of gender-responsive safety nets and their increased coverage for improving intrahousehold nutritional disadvantages.
DIVERSIFICATION IN CATASTROPHE INSURANCE MARKETS
Authors: Cui Hengxin , Tan Ken Seng , Yang Fan 
Published: July 2021

AbstractCatastrophe insurance markets fail to provide sufficient protections against natural catastrophes, whereas they have the capacity to absorb the losses. In this paper, we assume the catastrophic risks are dependent and extremely heavy-tailed, and insurers have limited liability to cover losses up to a certain amount. We provide a comprehensive study to show that the diversification in the catastrophe insurance markets can be transited from suboptimal to preferred by increasing the number of insurers in the market. This highlights the importance of coordination among insurers and the government intervention in encouraging insurers to participate in the catastrophe insurance market to exploit risk sharing. Simulation studies are provided to illuminate the key findings of our results.
GOODSTEIN SEQUENCES BASED ON A PARAMETRIZED ACKERMANN–PÉTER FUNCTION
Authors: ARAI TOSHIYASU , WAINER STANLEY S. , WEIERMANN ANDREAS 
Published: July 2021

AbstractFollowing our [6], though with somewhat different methods here, further variants of Goodstein sequences are introduced in terms of parameterized Ackermann–Péter functions. Each of the sequences is shown to terminate, and the proof-theoretic strengths of these facts are calibrated by means of ordinal assignments, yielding independence results for a range of theories: PRA, PA,$\Sigma ^1_1$-DC$_0$, ATR$_0$, up to ID$_1$. The key is the so-called “Hardy hierarchy” of proof-theoretic bounding finctions, providing a uniform method for associating Goodstein-type sequences with parameterized normal form representations of positive integers.
Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms
Authors: Al-Shehhi Wafaa , Chau Vann , Boyd Jennifer , Snead Carter , Sharma Rohit , Donner Elizabeth , Go Cristina , Jain Puneet 
Published: July 2021

ABSTRACT:Objectives:This research aimed to study the short-term seizure outcomes following treatment with 8 mg/kg/day prednisolone in children with infantile spasms (IS) refractory to vigabatrin. We hypothesized that high-dose prednisolone may result in similar rates of electroclinical remission when compared to published ACTH rates.Methods:All consecutive children with hypsarrhythmia or hypsarrhythmia variant on EEG with/without IS, who had been treated with vigabatrin as first-line anti-seizure medication (ASM) followed by high-dose oral prednisolone (8 mg/kg/day; maximum 60 mg/day) in cases who did not respond to vigabatrin, were included. Clinical and electroclinical response (ECR) at 2 weeks following initiation of treatment and adverse effects were assessed.Results:Sixty-five children were included. A genetic etiology was seen in 38.5% cases. Complete ECR was seen in 30.8% (20/65) of the patients 2 weeks after vigabatrin. Complete ECR was noted in 77.8% (35/45) of the patients, 2 weeks after prednisolone initiation in children who failed vigabatrin, and this was sustained at 6 weeks in 66.7% (30/45) patients. Prednisolone was generally well tolerated.Conclusions:High-dose (8 mg/kg/day) oral prednisolone resulted in sustained complete ECR (at 6 weeks) in two-thirds of the children with hypsarrhythmia or hypsarrhythmia variant on EEG with/without parentally reported IS. It was generally well tolerated and found to be safe.
An index measuring adherence to New Zealand Infant Feeding Guidelines has convergent validity with maternal socio-demographic and health behaviours and with children’s body size
Authors: Castro Teresa G. , Gerritsen Sarah , Teixeira Juliana A. , Pillai Avinesh , Marchioni Dirce Maria L. , Grant Cameron C. , Morton Susan M. B. , Wall Clare R. 
Published: July 2021

AbstractUsing data from a nationally generalisable birth cohort, we aimed to: (i) describe the cohort’s adherence to national evidence-based dietary guidelines using an Infant Feeding Index (IFI) and (ii) assess the IFI’s convergent construct validity, by exploring associations with antenatal maternal socio-demographic and health behaviours and with child overweight/obesity and central adiposity at age 54 months. Data were from theGrowing Up in New Zealandcohort (n6343). The IFI scores ranged from zero to twelve points, with twelve representing full adherence to the guidelines. Overweight/obesity was defined by BMI-for-age (based on the WHO Growth Standards). Central adiposity was defined as waist-to-height ratio > 90th percentile. Associations were tested using multiple linear regression and Poisson regression with robust variance (risk ratios, 95 % CI). Mean IFI score was 8·2 (sd2·1). Maternal characteristics explained 29·1 % of variation in the IFI score. Maternal age, education and smoking had the strongest independent relationships with IFI scores. Compared with children in the highest IFI tertile, girls in the lowest and middle tertiles were more likely to be overweight/obese (1·46, 1·03, 2·06 and 1·56, 1·09, 2·23, respectively) and boys in the lowest tertile were more likely to have central adiposity (1·53, 1·02, 2·30) at age 54 months. Most infants fell short of meeting national Infant Feeding Guidelines. The associations between IFI score and maternal characteristics, and children’s overweight/obesity/central adiposity, were in the expected directions and confirm the IFI’s convergent construct validity.
Managerial Trustworthiness and Buybacks
Authors: Huang Sterling , Snellman Kaisa , Vermaelen Theo 
Published: July 2021

AbstractCEO trustworthiness is positively related to long-term excess returns after buyback announcements. When the Chief Executive Officer (CEO) is trustworthy, statements that the stock is undervalued are more credible. CEO trustworthiness is initially measured by the extent to which people in the county where the company headquarters is located trust each other. Further, the positive impact of trustworthiness on excess returns is higher when the CEO has been a long-term resident of a high-trust county, and correspondingly, trustworthy CEOs are less likely to be accused of financial misreporting. Our conclusions are confirmed when we use alternative measures of trustworthiness such as employee trust and CEO integrity.
Long-term clinical outcomes of coronary artery bypass grafting in young children with Kawasaki disease
Authors: Kwak Yujin , Kwak Jae Gun , Cho Sungkyu , Kim Woong-Han 
Published: July 2021

AbstractBackground:Although coronary artery bypass grafting is not frequently performed in children, Kawasaki disease is one of the most common indications for coronary artery bypass grafting in children. Here, we reviewed the long-term clinical outcomes including graft patency after coronary artery bypass grafting.Methods:Between March 2004 and March 2013, six patients with Kawasaki disease underwent coronary artery bypass grafting. All patients were male. Their median age was 13.0 years (interquartile range, 7.8–17.8 years) at the timing of coronary artery bypass grafting, and the median age at the onset of Kawasaki disease was 3.3 years (interquartile range, 1.0–7.0 years). Four patients presented with multiple lesions including aneurysms.Results:The median follow-up duration was 12.1 years (interquartile range, 9.5–13.1 years), and there were no operative complications or overall mortality. One patient had pre-operative symptoms such as exertional chest pain and dyspnoea on exertion, whereas one patient had ventricular tachyarrhythmia. There was an improvement in subjective symptoms after surgery in two patients. The left internal thoracic artery, right internal thoracic artery, and saphenous vein were used in five (83.3%), one (16.7%), and two (33.3%) cases, respectively. In all six patients, post-operative single-photon emission CT findings showed improved perfusion compared with pre-operative single-photon emission CT. All grafts were patent as confirmed by coronary angiography or CT angiography.Conclusions:Coronary artery bypass grafting could be a good surgical option in children with coronary lesions caused by Kawasaki disease in terms of graft patency and myocardial perfusion.
Deception detection in text and its relation to the cultural dimension of individualism/collectivism
Authors: Papantoniou Katerina , Papadakos Panagiotis , Patkos Theodore , Flouris George , Androutsopoulos Ion , Plexousakis Dimitris 
Published: July 2021

AbstractAutomatic deception detection is a crucial task that has many applications both in direct physical and in computer-mediated human communication. Our focus is on automatic deception detection in text across cultures. In this context, we view culture through the prism of the individualism/collectivism dimension, and we approximate culture by using country as a proxy. Having as a starting point recent conclusions drawn from the social psychology discipline, we explore if differences in the usage of specific linguistic features of deception across cultures can be confirmed and attributed to cultural norms in respect to the individualism/collectivism divide. In addition, we investigate if a universal feature set for cross-cultural text deception detection tasks exists. We evaluate the predictive power of different feature sets and approaches. We create culture/language-aware classifiers by experimenting with a wide range of n-gram features from several levels of linguistic analysis, namely phonology, morphology and syntax, other linguistic cues like word and phoneme counts, pronouns use, etc., and token embeddings. We conducted our experiments over eleven data sets from five languages (English, Dutch, Russian, Spanish, and Romanian), from six countries (United States of America, Belgium, India, Russia, Mexico, and Romania), and we applied two classification methods, namely logistic regression and fine-tuned BERT models. The results showed that the undertaken task is fairly complex and demanding. Furthermore, there are indications that some linguistic cues of deception have cultural origins and are consistent in the context of diverse domains and data set settings for the same language. This is more evident for the usage of pronouns and the expression of sentiment in deceptive language. The results of this work show that the automatic deception detection across cultures and languages cannot be handled in unified manners and that such approaches should be augmented with knowledge about cultural differences and the domains of interest.
Article 21.5 DSU Appellate Body Report United States – Measures Affecting Trade in Large Civil Aircraft (Second Complaint): Spillovers from Defense R&D Add to the Tug-of-War between Panels and the WTO Appellate Body
Authors: Hillman Jennifer A. , Reynolds Kara M. 
Published: July 2021

AbstractThe March 2019 release of the Appellate Body's compliance report in United States – Measures Affecting Trade in Large Civil Aircraft (Second Complaint) marks yet another chapter in the ongoing Boeing–Airbus dispute. While raising numerous new and old subsidy issues, this paper focuses on one specific aspect, the evaluation of the financial contributions and benefits associated with the Department of Defense (DOD) R&D procurement contracts. The paper describes the differing views taken by the panels compared to the Appellate Body. It highlights two issues that led to an extremely lengthy proceeding: (1) the black or white nature of the decision regarding the characterization of contracts which have features of both purchases of services and joint ventures; and (2) the difficulty in demonstrating a financial contribution flowing from payments for R&D for military systems to Boeing's civil aircraft production. It concludes that this case represents a failure of the WTO dispute settlement system and underscores flaws in the ASCM in that after fifteen years of litigation, no determination was made as to whether or not the DOD R&D contracts examined here constituted impermissible subsidies.
Clinical negligence cases in the English NHS: uncertainty in evidence as a driver of settlement costs and societal outcomes
Authors: Carter Alexander W. , Mossialos Elias , Redhead Julian , Papalois Vassilios 
Published: July 2021

AbstractThe cost of clinical negligence claims continues to rise, despite efforts to reduce this now ageing burden to the National Health Service (NHS) in England. From a welfarist perspective, reforms are needed to reduce avoidable harm to patients and to settle claims fairly for both claimants and society. Uncertainty in the estimation of quanta of damages, better known as financial settlements, is an important yet poorly characterised driver of societal outcomes. This reflects wider limitations to evidence informing clinical negligence policy, which has been discussed in recent literature. There is an acute need for practicable, evidence-based solutions that address clinical negligence issues, and these should complement long-standing efforts to improve patient safety. Using 15 claim cases from one NHS Trust between 2004 and 2016, the quality of evidence informing claims was appraised using methods from evidence-based medicine. Most of the evidence informing clinical negligence claims was found to be the lowest quality possible (expert opinion). The extent to which the quality of evidence represents a normative deviance from scientific standards is discussed. To address concerns about the level of uncertainty involved in deriving quanta, we provide five recommendations for medico-legal stakeholders that are designed to reduce avoidable bias and correct potential market failures.
Multi‐Point Measurements of the Plasma Properties Inside an Aurora From the SPIDER Sounding Rocket
Authors: Giono Gabriel , Ivchenko Nickolay , Sergienko Tima , Brändström Urban 
Published: July 2021

AbstractThe Small Payloads for Investigation of Disturbances in Electrojet by Rockets (SPIDER) sounding rocket was launched on February 2nd, 2016 (21:09 UT), deploying 10 free falling units (FFUs) inside a westward traveling auroral surge. Each FFUs deployed spherical electric field and Langmuir probes on wire‐booms, providing in situ multi‐point recordings of the electric field and plasma properties. The analytical retrieval of the plasma parameters, namely the electron density, electron temperature and plasma potential, from the Langmuir probe measurements was non‐trivial due to sheath effects and detailed explanation are discussed in this article. An empirical assumption on the sheath thickness was required, which was confirmed by simulating the plasma environment around the FFU using the Spacecraft Plasma Interaction Software (SPIS). In addition, the retrieved electron density and temperature are also in agreement with the simultaneous incoherent scatter radar measurements from the EISCAT facility. These two independent confirmations provided a good level of confidence in the plasma parameters obtained from the FFUs, and events observed during the flight are discussed in more details. Hints of drift‐wave instabilities and increased currents inside a region of enhanced density were observed by the FFUs.