bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change of right ventricular systolic pressure can indicate dasatinib‐induced pulmonary arterial hypertension in chronic myeloid leukemia
Authors: Lee Sung‐Eun , Hyun Kong Jee , Kim Soo‐Hyun , Jang Eun‐Jung , Chung Nack‐Gyun , Cho Bin , Joong Oh Suk , Jung Hae‐Eok , Youn Ho‐Joong , Chung Woo‐Baek , Kim Dong‐Wook 
Published: February 2021

AbstractBackgroundWe investigated the feasibility of the clinical application of non‐invasive transthoracic echocardiography for diagnosis of pulmonary arterial hypertension induced by dasatinib (D‐PAH) in chronic myeloid leukemia (CML).MethodsA total of 451 CML patients who were examined by 2D‐echocardiography at least once at baseline and/or during dasatinib therapy as frontline (n = 196) and subsequent line (n = 255) therapies were included in this study. D‐PAH was defined as right ventricular systolic pressure (RVSP) >40 mm Hg with relevant symptoms and the absence of other specific etiologies.ResultsA total of 847 echocardiographies were performed including at baseline (n = 255) and during dasatinib treatment (n = 592). During the median of 36.2 (0.1–181.8) months of dasatinib therapy, the level of RVSP gradually increased (Spearman's r = 0.2819, p < 0.001) and the mean RVSP was significantly increased after taking dasatinib therapy compared with baseline. During dasatinib therapy, 56 (12.4%) patients had RVSP >40 mm Hg without (asymptomatic, n = 27, 48.2%) or with symptoms (D‐PAH, n = 29, 51.8%). All asymptomatic patients maintained dasatinib therapy without further symptoms and the D‐PAH patients ultimately switched to other tyrosine kinase inhibitors. After dasatinib discontinuation, 13 (45%) and 15 (52%) patients showed RVSP normalization and gradual decrease, respectively.ConclusionsOur large cohort study demonstrated that the gradual increment of RVSP might be induced by dasatinib and non‐invasive echocardiography can be fast way for early diagnosis as well as for monitoring of D‐PAH.
Mapping the influence of country‐of‐origin knowledge, consumer ethnocentrism, and perceived risk on consumer action against foreign products
Authors: Ortega‐Egea José Manuel , García‐de‐Frutos Nieves 
Published: February 2021

AbstractConsumers in Western markets are often called against foreign‐made products and their country‐of‐origin (COO), particularly against controversial COOs and products. As a result, Asian emerging countries and their manufacturing industries (e.g., apparel, toys, or chemicals) have become major targets of anti‐consumption in the West, with criticism rooted in political‐economic, social, and/or environmental issues. In addition, Western consumers' ethnocentric tendencies are often reinforced by campaigning for domestic product/service alternatives. This backdrop raises questions about the degree of consumers' macro COO knowledge and ethnocentrism, and of their importance as levers of consumer concern about (i.e., risk perceptions) and anti‐consumption of foreign products from a controversial COO. This article thus sheds light on the extent to which COO knowledge (whether macro or based on usage experience), along with consumer ethnocentrism, can be considered antecedents of two risk perception types and, in turn, of country‐driven anti‐consumption (CDAC)—in the context of this work, Spanish consumers' reluctance to buy and (non‐)ownership of Chinese apparel products. The findings reveal that consumer ethnocentrism heightens both psycho‐social and performance risk perceptions and contributes to reluctance to buy. Macro COO knowledge affects CDAC only indirectly through performance risk perceptions. By contrast, usage experience attenuates both performance and psycho‐social risk perceptions and directly affects foreign product ownership. Risk perceptions predict and mediate most of the effects of COO knowledge, consumer ethnocentrism, and usage experience on CDAC outcomes. Implications for research, policy, and practice are also discussed.
Customers' social interactions and panic buying behavior: Insights from social media practices
Authors: Naeem Muhammad , Ozuem Wilson 
Published: February 2021

AbstractThe Covid‐19 pandemic led to social distancing and lockdown practices, which increased social interactions and information exchange on social media for timely decision making. This study explores how social practices and social influence generated through social media created panic buying behavior among customers. A social constructionist epistemological position was taken in order to understand the social practice of information sharing and to ask why different meanings were ascribed to Covid‐19 pandemic. Qualitative data collection and analysis methods were used to understand these subjective realities. A total of 40 UK customers participated in semi‐structured interviews in which they were asked about their usage of social media during the pandemic. Results revealed that social media increased the sharing of viral video evidence, such as empty shelves and quarreling in grocery stores, which increased fear and uncertainty; as a result, people shared recommendations to stay at home and buy extra for survival. Analysis revealed that social media increased awareness of stock unavailability in other parts of world, such as the USA, China, and Germany; therefore, people took proactive actions, such as stockpiling or panic buying, to avoid risks and uncertainties. The major theoretical contribution of this study is that the researcher merged social practice theory and social influence theory, and constructed a research framework which provides understanding of the social factors generated through social media platforms that increased socially influenced panic buying practices among UK customers. This study suggests that there is a need to control socially shared information and panic buying behavior and how socially shared information can influence different people in different contexts.
Increasing stroke events in patients with ST elevation myocardial infraction and cardiogenic shock: A cause for concern
Authors: Kayani Waleed T. , Jneid Hani 
Published: February 2021

Key Points
The incidence of stroke in patients with STEMI complicated by cardiogenic shock (CS) is much higher than in those without CS. Use of percutaneous Mechanical Circulatory Support (MCS) is associated with a higher incidence of stroke in these patients; however, a causal relationship cannot be inferred.
Careful attention should be given to stroke mitigation and management strategies in this cohort and judicious use of MCS is warranted.
Future prospective clinical studies are needed to examine the impact of MCS on stroke incidence in these patients and further validate these clinically important findings.
Negative impact of coronavirus on interventional cardiology fellows' training: Let's limit collateral damage of the pandemic
Authors: Tarantini Giuseppe , Nai Fovino Luca 
Published: February 2021

Key Points
Coronavirus disease pandemic has caused a dramatic reduction of elective and urgent interventional cardiology procedures, with a negative impact on training of interventional cardiology fellows.
This study showed that 95% of interventional cardiology fellows during the first wave of the COVID‐19 pandemic believe that their training would be moderately or severely impacted by the health crisis.
Interventional cardiology programs need to reorganize in order to ensure safe pathways for both urgent and elective cases, primarily for patients' care but also to grant an adequate caseload for trainees.
Hemodynamic compromise in pulmonary embolism: “A tale of two ventricles”
Authors: Bowers Terry , Goldstein James A. 
Published: February 2021

Key Points
In acute pulmonary embolism (PE), low cardiac output (CO)–hypotension results from disparate ventricular conditions: The left ventricle (LV) is under‐filled and contracting vigorously, whereas the right ventricle (RV) is failing and dilated.
The proximate cause of LV preload deprivation is thrombus‐induced pulmonary vascular obstruction; abruptly increased pulmonary vascular resistance (PVR) induces acute RV systolic dysfunction which further compromises trans‐pulmonary flow.
“Escalation of Care” interventions (thrombolytics and aspiration thrombectomy) improve systemic hemodynamics by increasing LV preload delivery directly by reducing PVR and indirectly by relief of the strained failing RV.
Case of rupture ectopic pregnancy with emergency contraception levonorgestrel 0.075 mg in a lactating woman
Authors: Masud Nazish , AlShaibi Saleh , AlBassri Tala , Khan Saad , Khan Fahad 
Published: February 2021

AbstractLevonorgestrel emergency contraception (LNG‐EC) tends to make uterus unfavorable for implantation but does not prevent embryo implantation. Emergency contraceptives pills should be used with caution among lactating women who at the same time should be monitored closely for ectopic pregnancy.
Mycobacterium infection as a mimicker of brain metastasis
Authors: de Oliveira Wertheimer Guilherme Soares , Rossi Assis‐Mendonça Guilherme , de Souza Queiroz Luciano , Reis Fabiano 
Published: February 2021

AbstractMycobacterium infection is a differential diagnosis to be considered in brain multifocal lesions with peripheral enhancement.
Pierpont syndrome‐Report of a new patient
Authors: Ismaili–Jaha Vlora , Spahiu‐Konusha Shqipe , Jaha Art 
Published: February 2021

AbstractWe report on a 6‐year‐old girl with Pierpont Syndrome who was diagnosed using the whole‐exome sequencing technique. In addition to commonly recognized traits, our patient had scoliosis, a feature reported only in one other occasion.
Selective Hydrogenolysis of Biomass‐Derived Xylitol to Glycols: Reaction Network and Kinetics
Authors: Heisig Carina , Glotzbach Christoph , Schirrmeister Steffen , Turek Thomas 
Published: February 2021

AbstractThe conversion of bio‐based xylitol to ethylene glycol (EG) and propylene glycol (PG) was studied to replace the petrochemical production route and achieve a sustainable process. The reaction network for aqueous‐phase catalytic hydrogenolysis of xylitol over a supported Pt catalyst with Ca(OH)2 as promotor was identified and the reaction kinetics was determined. The effects of reaction conditions such as educt concentration, H2 pressure, and temperature were investigated. With the developed kinetic model, the composition of the product mixture regarding the desired products (EG, PG) and by‐products can be described. The maximum EG yield was achieved at high pressure and low temperature, while high pressure and temperature favored PG production.
Utilization of image interpolation and fusion in brain tumor segmentation
Authors: El‐Hag Noha A. , Sedik Ahmed , El‐Banby Ghada M. , El‐Shafai Walid , Khalaf Ashraf A. M. , Al‐Nuaimy Waleed , Abd El‐Samie Fathi E. , El‐Hoseny Heba M. 
Published: February 2021

AbstractBrain tumor is a mass of anomalous cells in the brain. Medical imagining techniques have a vital role in the diagnosis of brain tumors. Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) techniques are the most popular techniques to localize the tumor area. Brain tumor segmentation is very important for the diagnosis of tumors. In this paper, we introduce a framework to perform brain tumor segmentation, and then localize the region of the tumor, accurately. The proposed framework begins with the fusion of MR and CT images by the Non‐Sub‐Sampled Shearlet Transform (NSST) with the aid of the Modified Central Force Optimization (MCFO) to get the optimum fusion result from the quality metrics perspective. After that, image interpolation is applied to obtain a High‐Resolution (HR) image from the Low‐Resolution (LR) ones. The objective of the interpolation process is to enrich the details of the fusion result prior to segmentation. Finally, the threshold and the watershed segmentation are applied sequentially to localize the tumor region, clearly. The proposed framework enhances the efficiency of segmentation to help the specialists diagnose brain tumors.
A current‐mode MOSFET‐C analog filter for the high‐frequency band applications
Authors: Ozenli Deniz , Yesil Abdullah , Kuntman Hakan 
Published: February 2021

SummaryIn this work, a novel current‐mode filter is presented including a PMOS grounded capacitor and a metal insulator metal structure (MIM‐cap). Proposed filter's cut‐off frequency can be easily adjusted from 10 up to 35 MHz. The wide tuning range of the proposed filter is designed to cover the need of baseband filter in the high‐frequency band and wireless applications such as CDMA, IEEE802.11a/g, IEEE 802.11b, and IEEE 802.11n. In addition, the proposed filter is designed by using a design methodology employing polynomial regressive models of small signal parameters of transistors to provide design accuracy as high as possible. Designed filter structure has layout with 52.1 μm × 62.6 μm chip area, and post‐layout simulations are given extensively to prove performance of the filter. Furthermore, 1‐dB compression point and IIP3 analyses are highlighted to observe linearity of band‐pass output of the filter structure. Also, input‐referred noise characteristics of the filter outputs are investigated to overcome thermal noise effects worsening the performance for a wide range of operating frequency interval. Provided results show that the proposed filter scheme brings a promising opportunity to designers for the high‐frequency region operations.
Healthcare experience among patients with type 2 diabetes: A cross‐sectional survey using the IEXPAC tool
Authors: Orozco‐Beltrán Domingo , Artola‐Menéndez Sara , Hormigo‐Pozo Antonio , Cararach‐Salami Daniel , Alonso‐Jerez Juan Luis , Álvaro‐Grande Epifanio , Villabrille‐Arias Covadonga , de Toro‐Santos Francisco Javier , Galindo‐Puerto María José , Marín‐Jiménez Ignacio , Gómez‐García Antón , Ledesma‐Rodriguez Rocío , Fernández Gonzalo , Ferreira de Campos Karine 
Published: February 2021

AbstractAimTo assess the experience with health care among patients with type 2 diabetes (T2DM) and to evaluate patients’ demographic variables and healthcare‐related characteristics which may affect their experience.MethodsA cross‐sectional survey was delivered to T2DM adults. Patient experiences were assessed with the ‘Instrument for Evaluation of the Experience of Chronic Patients’ (IEXPAC) questionnaire, a validated 12‐item survey, which describes patient experience within the last 6 months (items 1–11) and hospitalization in the last 3 years (item 12), with possible scores ranging from 0 (worst) to 10 (best experience).ResultsA total of 451 T2DM patients responded to the survey (response rate 72.3%; mean age 69.5 ± 10.1 years, 67.8% men). The mean overall IEXPAC score was 5.92 ± 1.80. Mean scores were higher for productive interactions (7.92 ± 2.15) and self‐management (7.08 ± 2.27) than for new relational model (1.72 ± 2.01). Only 32.8% of patients who had been hospitalized in the past 3 years reported having received a follow‐up call or visit after discharge. Multivariate analyses identified that regular follow‐up by the same physician and follow‐up by a nurse were associated with a better patient experience. Continuity of healthcare score was higher only in those patients requiring help from others.ConclusionsThe areas of T2DM care which may need to be addressed to ensure better patient experience are use of the Internet, new technologies and social resources for patient information and interaction with healthcare professionals, closer follow‐up after hospitalization, and a comprehensive multidisciplinary approach with regular follow‐up by the same physician and a nurse.
Monitoring institutions in healthcare markets: Experimental evidence
Authors: Angerer Silvia , Glätzle‐Rützler Daniela , Waibel Christian 
Published: February 2021

AbstractThis paper investigates the impact of monitoring institutions on market outcomes in health care. Healthcare markets are characterized by asymmetric information. Physicians have an information advantage over patients with respect to appropriate treatments, which they may exploit through over‐ or under‐provision or by overcharging. We introduce two types of costly monitoring: endogenous and exogenous monitoring. When monitoring detects misbehavior, physicians have to pay a fine. Endogenous monitoring can be requested by patients, while exogenous monitoring is performed randomly by a third party. We present a toy model that enables us to derive hypotheses and test them in a laboratory experiment. Our results show that introducing endogenous monitoring reduces the level of undertreatment and overcharging. Even under high monitoring costs, the threat of patient monitoring is sufficient to discipline physicians. Exogenous monitoring also reduces undertreatment and overcharging when performed sufficiently frequently. Market efficiency increases when endogenous monitoring is introduced and when exogenous monitoring is implemented with sufficient frequency. Our results suggest that monitoring may be a feasible instrument to improve outcomes in healthcare markets.
Influence of regional white matter hyperintensity volume and apolipoprotein E ε4 status on hippocampal volume in healthy older adults
Authors: Van Etten Emily J. , Bharadwaj Pradyumna K. , Hishaw Georg A. , Huentelman Matthew J. , Trouard Theodore P. , Grilli Matthew D. , Alexander Gene E. 
Published: February 2021

AbstractWhile total white matter hyperintensity (WMH) volume on magnetic resonance imaging (MRI) has been associated with hippocampal atrophy, less is known about how the regional distribution of WMH volume may differentially affect the hippocampus in healthy aging. Additionally, apolipoprotein E (APOE) ε4 carriers may be at an increased risk for greater WMH volumes and hippocampal atrophy in aging. The present study sought to investigate whether regional WMH volume mediates the relationship between age and hippocampal volume and if this association is moderated by APOE ε4 status in a group of 190 cognitively healthy adults (APOE ε4 status [carrier/non‐carrier] = 59/131), ages 50–89. Analyses revealed that temporal lobe WMH volume significantly mediated the relationship between age and average bilateral hippocampal volume, and this effect was moderated by APOE ε4 status (−0.020 (SE = 0.009), 95% CI, [−0.039, −0.003]). APOE ε4 carriers, but not non‐carriers, showed negative indirect effects of age on hippocampal volume through temporal lobe WMH volume (APOE ε4 carriers: −0.016 (SE = 0.007), 95% CI, [−0.030, −0.003]; APOE ε4 non‐carriers: .005 (SE = 0.006), 95% CI, [−0.006, 0.017]). These findings remained significant after additionally adjusting for sex, years of education, hypertension status and duration, cholesterol status, diabetes status, Body Mass Index, history of smoking, and the Wechsler Adult Intelligence Scale‐IV Full Scale IQ. There were no significant moderated mediation effects for frontal, parietal, and occipital lobe WMH volumes, with or without covariates. Our findings indicate that in cognitively healthy older adults, elevated WMH volume regionally localized to the temporal lobes in APOE ε4 carriers is associated with reduced hippocampal volume, suggesting greater vulnerability to brain aging and the risk for Alzheimer's disease.
Impact of comorbidities and body mass index on the outcome of polycythemia vera patients
Authors: Benevolo Giulia , Elli Elena M. , Bartoletti Daniela , Latagliata Roberto , Tiribelli Mario , Heidel Florian H. , Cavazzini Francesco , Bonifacio Massimiliano , Crugnola Monica , Binotto Gianni , D'Addio Alessandra , Tieghi Alessia , Bergamaschi Micaela , Caocci Giovanni , Polverelli Nicola , Bossi Elisa , Auteri Giuseppe , Carmosino Ida , Catani Lucia , Cuneo Antonio , Krampera Mauro , Lanza Francesco , Lemoli Roberto M. , Vianelli Nicola , Breccia Massimo , Palumbo Giuseppe A. , Cavo Michele , Palandri Francesca 
Published: February 2021

AbstractIn 816 patients with 2016 World Health Organization‐defined polycythemia vera (PV) enrolled in a multicenter retrospective study, we investigated the predictive value of Charlson comorbidity index (CCI) and body mass index (BMI) on thrombosis, progression to post‐PV myelofibrosis (PPV‐MF) and survival. Patients were subgrouped according to CCI = 0 (58.1%, no comorbidities) or CCI ≥ 1 (41.9%) and according to normal/underweight (BMI < 25, 54.5%) or overweight/obesity (BMI ≥ 25, 45.5%) at PV diagnosis. BMI was available for 529 patients. Patients with CCI ≥ 1 were older and more frequently presented cardiovascular risk factors compared to patients with CCI = 0 (p < 0.001), while overweight/obese patients were more frequently males (p < 0.001). Cumulative incidence of thromboses with death as competing risk was 13.3% at 10 years. Multivariable analysis with death as competing risk showed that previous thromboses (subdistribution hazard ratio [SHR]: 2.1, p = 0.01) and hypertension (SHR: 1.77, p = 0.04) were significantly associated with a higher thrombotic risk, while BMI ≥ 25 lost statistical significance (SHR: 1.69, p = 0.05) and CCI ≥ 1 was excluded after evaluation of goodness of fit. After a median follow‐up of 6.1 years, progression to PPV‐MF occurred in 44 patients, and 75 patients died. BMI ≥ 25 was associated with a lower probability of progression to PPV‐MF (SHR: 0.38, CI95%: 0.15–0.94, p = 0.04) and better survival (hazard ratio [HR]: 0.42, CI95%: 0.18–0.97, p = 0.04). CCI ≥ 1 did not affect progression to PPV‐MF (p = 0.44) or survival (p = 0.71). The evaluation of CCI and BMI may improve the prognostic definition of PV. In patients with hypertension an accurate evaluation of thrombotic risk is warranted.
Resources management impact on neonatal services performance in the United Kingdom: A system dynamics modelling approach
Authors: Lebcir Reda , Atun Rifat 
Published: February 2021

AbstractDemand for neonatal care in the United Kingdom (UK) has increased in recent years. This care is provided by neonatal services, which are chronically saturated due to years of budget austerity in the UK. The aim of this paper is to investigate the possible impact of increasing resources to these services to improve their operational performance and alleviate the pressure they are facing. To achieve this aim, a system dynamics (SD) simulation model was built and validated in a UK neonatal unit. The SD model was used initially to evaluate the impact of increasing resources on the unit performance and the results showed that this policy will have a limited effect on performance. The model was then extended to predict the effect of reducing the length of stay (LoS) in conjunction with increasing resources. These joint interventions will have a positive impact on the unit performance if LoS is reduced for all care categories and resources are slightly increased. Results' implications and SD's modelling usefulness to guide decision making in complex health settings are discussed.