bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemicals Target Growth Factor Receptors to Control Cancer: An In Silico Study
Authors: Mendie Love Edet , Hemalatha S 
Published: August 2021

Abstract
Drug delivery in a safe manner is a major challenge in the drug development process. Growth factor receptors (GFRs) are known to have profound roles in the growth and progression of cancerous cells making these receptors a therapeutic target in the effective treatment of cancer. This work focused on exploring bioactive compounds that can target GFRs usingin-silico method. In this study, 50 bioactive compounds from different plant sources were screened as anticancer agent against GFRs using drug likeness parameters of Lipinski’s rule of five. The molecular docking was performed between phytochemicals and GFRs. Ligands with acceptable drug likeness and binding energy comparable to the standard drugs were further screened to determine their pharmacokinetic activities. This study showed phytochemicals with the binding energy comparable with the standard drugs (Dovitinb and Geftinib), while ADME, bioactivity score and bioavailability radar analysis gave further insight on these compounds as potent anticancer agents.
Effects of Individualized Gait Rehabilitation Robotics for Gait Training on Hemiplegic Patients: Before-After Study in The Same Person
Authors: Guo Zhao , Ye Jing , Zhang Shisheng , Xu Lanshuai , Chen Gong , Guan Xiao , Li Yongqiang , Zhang Zhimian 
Published: August 2021

Abstract
Background : Lower-limb exoskeleton robots are being widely used in gait rehabilitation training for stroke patients. However, most of the current rehabilitation robots are guided by predestined gait trajectories, which are often different from the actual gait trajectories of specific patients. One solution is to train patients using individualized gait trajectories generated from the physical parameters of patients. Hence, we aimed to explore the effect of individual gaits on energy consumption situation during gait rehabilitation training for hemiplegic patient with low-limb exoskeleton robot.Methods : 9 unilateral-hemiplegic patients were recruited. On the first day of the experiment, the 9 patients were guided by a low-limb exoskeleton robot, walking on a flat ground for 15 minutes in general gait trajectory, which was gained by CGA (clinical gait analysis) method.On the other day, the same 9 patients wore the identical robot and walked on the same flat ground for 15 minutes in individualized gait trajectory. The main physiological parameters including heart rate (HR) and peripheral capillary oxygen saturation (SpO2) were acquired via cardiotachometer and oximeter before and after the walking training. The energy consumption situation was indicated by the variation of the value of HR and SpO2 after walking training compared to before.Results : Between-group comparison shows that the individualized gait trajectory training results in lower increase in HR levels and decrease in SpO2 levels in experimenters compared to general gait trajectory training. Difference has statistical significance(p<0.05).Conclusions : Using individualized gait guidance in rehabilitation walking training can significantly improve energy efficiency for hemiplegic patient with stroke.Trial registration: Registered on 29 July 2021 at Chinese Clinical Trial Registry (ChiCTR2100049310). https://www.chictr.org.cn/edit.aspx?pid=130960\&htm=4
Health equity impact of community-initiated kangaroo mother care: A randomized controlled trial
Authors: Choudhary Tarun Shankar , Mazumder Sarmila , Haaland Oystein Ariansen , Taneja Sunita , Bahl Rajiv , Martines Jose Carlos , Bhan Maharaj Kishan , Johansson Kjell Arne , Sommerfelt Halvor , Bhandari Nita , Norheim Ole Frithjof 
Published: August 2021

Abstract
BackgroundKangaroo mother care (KMC) can substantially enhance overall survival of low birthweight babies. In a large randomized controlled trial, we recently showed that supporting mothers to provide community initiated KMC (ciKMC) can reduce early infant mortality by 25% (hazard ratio (HR) 0.75). With the current analysis we aimed to explore if ciKMC promotion leads to increased inequity in survival.MethodsIn the trial we randomised 8402 low birthweight babies to a ciKMC (4480 babies) and a control (3922 babies) arm, between 2015 and 2018 in Haryana, India. The main outcome of interest was the difference in concentration indices between babies in the ciKMC and control arms for survival until 180 days of life.ResultsOur intervention did not increase survival inequity, as reflected in a reduction of the concentration index by 0.05 (95% CI -0.07 to 0.17). Survival impact tended to be higher among those born to illiterate mothers (HR 0.65, 95% CI 0.47 to 0.89), and those in poor families (HR 0.69, 95% CI 0.51 to 0.93).ConclusionsWe found that ciKMC promotion did not increase inequity in survival associated with wealth. The beneficial impact of ciKMC tended to be larger among vulnerable groups. Supporting mothers to provide KMC at home to low birthweight babies will not increase and could indeed reduce inequities in infant survival.Trial registrationClinicalTrials.gov, NCT02653534. Registered January 12, 2016 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02653534
An Anatomical Study of Incisive Canal and its Foramen
Authors: Quevedo Beatriz , Sangalette Beatriz , Lopes Ivna , Shindo João Vitor , Andreo Jesus Carlos , Rubira Cássia Maria , Rubira-Bullen Izabel Regina , Shinohara André Luis 
Published: August 2021

Abstract
Introduction: Anatomically, the incisive canals start on the nasal fossa floor, close to the septum, and open at the incisive foramen of the maxillary palatine process. The nasopalatine nerve passes through the incisive foramen as well as the septal artery and the sphenopalatine vein. Also, there may be accessory canals. Typically, the incisive foramen has two incisive canals. This work aimed to analyze the morphology and morphometry of the foramen and incisive canals in the macerated cephalic skeletons. Material and methods: For this purpose, we selected 150 samples of adult individuals, with no distinctions of sex and ethnicity. We analyzed the frequency of incisive canals in the foramen was analyzed as well the area, diameter, and communications of incisive canals with the fossa and nasal cavity. Results: The cephalic analysis results showed that most incisive foramina have at least two canals that communicate the nasal cavity with the oral cavity. The right-side canal had an average of 1.975mm² in area and 1.281mm in diameter. Also, the left-side canal had an average of 1.468mm² in area and 1.182mm in diameter. The average area and total diameter of the incisive foramen were 8.148mm² and 3.101mm, respectively.Conclusion: Hence, understanding anatomy and its variations is essential for clinical applications, as it may alter surgical technique and prognosis. Besides, it can be said all incisive canals have communication with the nasal cavity.
Predictive Models for Personalized Asthma Attacks Based on Patient’s Biosignals and Environmental Factors: A Systematic Review
Authors: Alharbi Eman T. , Nadeem Farrukh , Cherif Asma 
Published: August 2021

Abstract
Background: Asthma is a chronic disease that exacerbates due to various risk factors, including the patient's biosignals and environmental conditions. It is affecting on average 7% of the world population. Preventing an asthma attack is the main challenge for asthma patients, which requires keeping track of any risk factor that can cause a seizure. Many researchers developed asthma attacks prediction models that used various asthma biosignals and environmental factors. These predictive models can help asthmatic patients predict asthma attacks in advance, and thus preventive measures can be taken. This paper introduces a review of these models to evaluate the used methods, model's performance, and determine the need to improve research in this field.Method: A systematic review was conducted for the research articles introducing asthma attack prediction models for children and adults. We searched the PubMed, ScienceDirect, Springer, and IEEE databases from January 2000 to December 2020. The search includes the prediction models that used biosignal, environmental, and both risk factors. The research article's quality was assessed and scored based on two checklists, the Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS) and the Critical Appraisal Skills Programme clinical prediction rule checklist (CASP). The highest scored articles were selected to review.Result: From 1068 research articles we reviewed, we found that most of the studies used asthma biosignal factors only for prediction, few of the studies used environmental factors, and limited studies used both of these factors. Fifteen different asthma attack predictive models were selected for this review. we found that most of the studies used traditional prediction methods, like Support Vector Machine and regression. We have identified the pros and cons of the reviewed asthma attack prediction models and propose solutions to advance the studies in this field.Conclusion: Asthma attack predictive models become more significant when using both patient's biosignal and environmental factors. There is a lack of utilizing advanced machine learning methods, like deep learning techniques. Besides, there is a need to build smart healthcare systems that provide patients with decision-making systems to identify risk and visualize high-risk regions.
The Role of Posterior Pallial Amygdala in Mediating Motor Behaviors in Pigeons
Authors: Tian Xinmao , Shi Yuhua , Zhang Yifeng , Wang Yijie , Li Mengke , Cheng Han , Wang Zhenlong 
Published: August 2021

Abstract
The posterior pallial amygdala (PoA) is located on the basolateral caudal telencephalon, including the basal division of PoA (PoAb) and the compact division of PoA (PoAc). PoA plays a vital role in emotion regulation and is considered a part of the amygdala in birds. However, the regulatory functions responsible for motor behaviors and emotions between PoAb and PoAc are poorly understood. Therefore, we studied the structure and function of PoA by tract-tracing methods, constant current electrical stimulation, and different dopamine receptor drug injections in pigeons (Columba livia). PoAb connects reciprocally with two nuclear groups in the cerebrum: 1) a continuum comprising the temporo–parieto–occipitalis, corticoidea dorsolateralis, hippocampus, and parahippocampalis areas and 2) rostral areas of the hemisphere, including the nucleus septalis lateralis and nucleus taeniae amygdalae. Extratelencephalic projections of PoAb terminate in the lateral hypothalamic nucleus and are scattered in many limbic midbrain regions. PoAb and PoAc mainly mediated the turning movement. D1 agonist and D2 antagonist could significantly reduce the latency period for entering into the central area and increase the stay time in the central area, whereas D1 antagonist and D2 agonist had the opposite effect. PoAb and PoAc are important brain areas that mediate turning behavior.
Serum Free Triiodothyronine Is Inversely Associated With Diabetic Peripheral Neuropathy but Not With Carotid Atherosclerotic Lesions in Type 2 Diabetic Patients With Euthyroid Function
Authors: Li Mei-Fang , Ke Jiang-Feng , Li Shuai , Wang Jun-Wei , Zhu Zhi-Hui , Li Jing-Bo 
Published: August 2021

Abstract
Background: The associations between serum free triiodothyronine (FT3) and diabetic peripheral neuropatprohy (DPN) / carotid atherosclerotic lesions in type 2 diabetic patients with normal thyroid function is still unclear. The purpose of our study was to explore the relationships of FT3 with DPN and carotid atherosclerotic lesions in Chinese type 2 diabetes inpatients with euthyroid function.Methods: A total of 2477 type 2 diabetes inpatients with euthyroid function were recruited in this cross-sectional study, and they were stratified into quartiles by FT3 levels. Peripheral neuropathy was assessed by neurological symptoms and signs as well as nerve conduction velocity tests. Carotid atherosclerotic lesions, including carotid intima-media thickness, plaque and stenosis, were evaluated by Doppler ultrasound. Results: After adjusting for potential confounders, there was a significant decrease in the prevalence of DPN in the patients with type 2 diabetes across the FT3 quartiles (23.5%, 20.9%, 18.9%, and 11.2%, respectively, p < 0.001). Logistical regression analysis further revealed that FT3 quartiles were significantly and inversely associated with DPN. Compared with the subjects in the highest FT3 quartile, the adjusted odds ratios (95% confidence interval) of DPN in the first to third FT3 quartile were successively 2.338 (1.407-3.884), 1.903 (1.134-3.194) and 1.598 (0.960-1.125). The patients with DPN had significantly higher prevalence of carotid plaques (55.8%) and carotid stenosis (1.3%) than non-DPN patients (44.8%; 0.5%). However, no statistical association was observed between FT3 quartiles and carotid atherosclerotic lesions.Conclusions: Lower FT3 within the normal range was independently associated with DPN, but not with carotid atherosclerotic lesions in Chinese type 2 diabetes inpatients with euthyroid function.
Serum Receptor Activator of Nuclear Factor-Kappa B Ligand Levels In Chinese Patients With Ankylosing Spondylarthritis: A Meta-Analysis
Authors: Ni Feifei , Zhang Yanchao , Peng Yi , Peng Xiaoxiao , Li Jianjun 
Published: August 2021

Abstract
Objective: We aimed to determine the association between serum receptor activator of nuclear factor-kappa B ligand (sRANKL) levels and ankylosing spondylarthritis (AS) in Chinese populations.Methods: The PubMed, Cochrane Library, Embase, Chinese Biomedical Database, Web of Science, China National Knowledge Infrastructure, VIP, and Wan Fang databases were searched for studies conducted before October 1, 2020 without language restrictions. STATA version 12.0 and Revman version 5.3 were used to analyze the data. The standard mean differences (SMDs) and corresponding 95% confidence intervals (95%CIs) were calculated. Results: Twelve clinical case–control studies, including 585 AS patients and 423 healthy controls, were included. The combined SMD for sRANKL suggested that the sRANKL level was significantly higher in the Chinese AS patients than in the healthy controls (SMD: 3.27, 95%CI: 2.11-4.43, P<0.00001). RANKL-related factor osteoprotegerin OPG (SMD: 0.86, 95%CI: 0.09-1.64, P<0.03) and RANKL/OPG (SMD=1.05, 95%CI=0.64-1.46, P<0.00001). Subgroup analysis indicated that the patients from North and South China had higher sRANKL levels than the controls; the patients sRANKL levels from South China were higher in the subgroup with Bath Ankylosing Spondylitis Functional Index (BASFI) >4. In terms of duration, ≤8years AS patients had higher sRANKL levels than the controls. Other subgroup analyses were conducted by region, language, source of control, age, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). In these subgroups, the sRANKL levels were significantly higher in the AS patients than in the controls. BASFI and BASDAI were sources of heterogeneity.Conclusions: The sRANKL levels are higher in the Chinese AS patients, especially among the patients from South China. sRANKL levels may be positively correlated with the pathogenesis of AS among the Chinese patients.
Synthesis and Characterization of Genistein Magnetic Molecularly Imprinted Polymers and Its Application in Soy Sauce Products
Authors: Xie Ziqi , Luo Yunjing , Na Zhen , Zhang Wei , Zong Yunfei 
Published: August 2021

Abstract
In this study, a novel method based on genistein magnetic molecularly imprinted polymers (Gen-MMIPs) was developed by surface molecular imprinting technique, in which genistein was used as the template molecule and Fe3O4 was used as the carrier. The synthesis of Gen-MMIPs were characterized by using of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), which indicated the diameters of Gen-MMIPs were about 500 nm. Through the technique of vibrating sample magnetometer (VSM), the saturation magnetization of Gen-MMIPs were detected as 24.79 emu/g. Fourier transform infrared (FR-IR) spectroscopy showed that polymer groups were on the surface of the magnetic carrier. Adsorption experiment suggested the adsorption capability of Gen-MMIPs to genistein were 1.55 mg/g, and 2 the adsorption equilibrium was achieved within 20 min. Gen-MMIPs as dispersive solid-phase extraction adsorbent combined with HPLC was used to selectively separate genistein in soy sauce samples, the recoveries were ranged from 85.7% to 88.5% with the relative standard deviations (RSD) less than 5%, which proved this method can be used for the detection of genistein residues in real samples.
Open-Source Software Library for Real-Time Inertial Measurement Unit Data-Based Inverse Kinematics using OpenSim
Authors: Lavikainen Jere , Vartiainen Paavo , Stenroth Lauri , Karjalainen Pasi 
Published: August 2021

Abstract
Background: An open-source software library for multithreaded real-time inverse kinematical (IK) analysis of inertial measurement unit (IMU) data using OpenSim was developed. Its operation delays and throughputs were measured with a varying number of IMUs and parallel computing IK threads using two different musculoskeletal models, one a lower-body and torso model and the other a full-body model. Results: Full-body inverse kinematics with data from 12 IMUs could be calculated in real-time with a mean delay below 100 ms and at more than 900 samples per second. Live visualization of IK is an option but results in limited IK throughput. The effect of this limitation was assessed by comparing the range of motion (ROM) of each joint from visualized real-time IK to the ROM from offline IK at IMU sampling frequency, resulting in mean ROM differences below 0.3 degrees. Conclusions: The software library enables real-time inverse kinematical analysis with different numbers of IMUs and customizable musculoskeletal models, making it possible to do subject-specific full-body motion analysis outside the motion laboratory in real-time.
The Safty Profile of Blood Salvage Applied for Collected Blood With Amniotic Fluid During Cesarean Section
Authors: Rong Xiaoying , Guo Xiangyang , Zeng Hong , Wang Jun , Li Mi , Wang Yang 
Published: August 2021

Abstract
Background: The guidelines of National Health Service(NHS) also recommended for use in obstetrics at increased risk of bleeding, requiring two sets to reduce amniotic fluid contamination, however, when comes to massive hemorrhage, it is may difficult to operate because the complex operation may delay time. The aim of the study was to detect the effect of amniotic fluid recovery on intraoperative cell salvage in obstetrics and provide evidence for clinical applications.Method: Thirty-four patients undergoing elective cesarean section were randomly divided into two groups. In group 1, the cumulative blood from the operation field, including the amniotic fluid, was collected using a single suction device for processing. In group 2, after suctioning away the amniotic fluid using another suction device for the cumulative blood from the operation field. From each group, four samples were taken, including maternal venous blood (sample I), blood before washing (sample II), blood after washing (sample III) and blood after filtration with a leukocyte filter (sample IV) , to detect serum potassium (K+), hemoglobin (Hb), white blood cell (WBC), fetal hemoglobin (HbF), alpha fetoprotein (AFP) and squamous cell (SC) levels.Results: The AFP, K+ and WBC levels of sample III and sample IV were significantly lower than sample I in group 1 and group 2 (P<0.05). Significantly more SCs were found in sample III than in sample I in group 1 and group 2 (P<0.05), but SCs of sample IV had no statistical difference compared to sample I in group 1 and group 2 (P>0.05). There was no significant difference in the K+, Hb, WBC, AFP and SC levels of sample IV between group 1 and group 2 (P>0.05). The HbF levels of sample III and sample IV were significantly higher in group 1 than in group 2 (P<0.05).Conclusion: There is little or no possibility for AF contamination to enter the re-infusion system when used in conjunction with a leucodepletion filter. In future, one set of suction device can be considered in obstetric emergency.Trial registration: ChiCTR1800015684, 2018.4.15
Multi-Objective Factors Optimization in Fused Deposition Modelling with Particle Swarm Optimization and Differential Evolution
Authors: Mellal Mohamed Arezki , Laifaoui Chahinaze , Ghezal Fahima , Williams Edward J. 
Published: August 2021

Abstract
The design of any system contemplates the elaboration of a prototype of the entire system or some parts, before the manufacturing phase. Nowadays, rapid prototyping (RP) is widely used by the designers. This paper addresses the multi-objective factors optimization of the fused deposition modelling (FDM) technology. The problem is converted into a single one using the weighted-sum method and then solved by resorting to two nature-inspired computing techniques, namely particle swarm optimization (PSO) and differential evolution (DE). The results obtained are compared.
Black Kites on a Flyway Between Western Siberia and the Indian Subcontinent
Authors: Literák Ivan , Škrábal Jan , Karyakin Igor V. , Andreyenkova Natalya G. , Vazhov Sergey V. 
Published: August 2021

Abstract
Background The Black Kite (Milvus migrans) is one of the most widespread raptors in the World. The Palaearctic is populated by two migrating subspecies, Milvus migrans migrans and Milvus migrans lineatus, in the western and eastern part of this realm, respectively. The intergradation zone of M. m. migrans/M. m. lineatus covers large areas in-between. Migration routes of M. m. migrans from Europe to Sub-Saharan Africa and the Middle East are well known including large waterbodies as main environmental obstacle. MethodsWe tagged with GPS/SMS/GPRS telemetry loggers 13 and 6 Black Kite pulli in lowland around Biysk and in mountains around Kosh-Agach. ResultsBlack Kites originating from Biysk migrated through the Western Circum-Himalayan Corridor. Black Kites originating from Kosh-Agach used the Trans-Himalayan Corridor crossing the Himalayas in altitudes of up to 6 256 m asl. The average total distance travelled of Black Kites from both subpopulations was 9 166 m without any significant differences between these subpopulations. Timing of autumn migration varied slightly among individuals in departure date (30 August ± 9 days) and differed more in arrival date (26 October ± 92 days). The timing of spring migration varied less in both departure date (17 April ± 12 days) and arrival date (09 May ± 14 days). Black Kites from both subpopulations wintered in low elevations of anthropogenic areas of Pakistan and India. Birds wintered on average for 190 days, and the mean area of individual home ranges was 4 704 km2. During the breeding period, birds occupied mainly natural or semi-natural habitats in southwestern Siberia, where they spent on average 106 days with an average home range size 3 554 km2. Conclusion Black Kites crossing the Himalayas fly and, moreover, stay for hours resting at night in the environment of mountains at altitudes over 5000 m. It seems that the vast breeding territory of Black Kites in the Palearctic realm is connected with the unusual behavioural flexibility of Black Kites to surmount various environmental obstacles on their migration routes.