bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanocelllulose Based Adsorbents for Heavy Metal Ions Removal
Authors: Si Rongrong , Wang Daiqi , Chen Yehong , Yu Dongmei , Ding Qijun , Li Ronggang , wu chaojun 
Published: June 2021

Abstract
Heavy metal ion pollutions are of serious threat for our human health, and advanced technologies on removal of heavy metal ions in water or soil are in the focus of intensive research worldwide. Nanocellulose based adsorbents are emerging as an environmentally friendly appealing materials platform for heavy metal ions removal as nanocellulose has higher specific surface area, excellent mechanical properties and good biocompatibility. In this review, we briefly compare the differences of three kinds of nanocellulose and their preparation method. Then we cover the most recent work on nanocellulose based adsorbents for heavy metal ions removal, and present an in-depth discussion of the modification technologies for nanocellulose in assembling high performance heavy ions adsorbent process. By introducing functional groups, such as amino, carboxyl, phenolic hydroxyl, and thiol, the nanocellulose based adsorbents not only remove single heavy metal ions through ion exchange, chelation/complexation/coordination, electrostatic attraction, hydrophobic actions, binding affinity and redox reactions, but also can selectively adsorb multiple heavy ions in water. Finally, some challenges of nanocellulose based adsorbents for heavy metal ions are also prospected. We anticipate that the review supplies some guides for nanocellulose based adsorbents applied in heavy metal ions removal field.
Start on the Right Foot: Choice in a Complex Early Environment Boosts Coping Abilities in the Domestic Fowl Chick
Authors: Nazar Nico , Skånberg Lena , McCrea Kirste , Keeling Linda 
Published: June 2021

Abstract
Early experience of a complex environment can improve biologically relevant traits related to coping abilities. However, the mechanisms underlying these positive effects are not well explored. We hypothesised that the possibility to express a choice, leading to increased control over the environment, could play an important role. In a balanced design, laying hen hatchlings were reared either in a ‘No-Choice’ environment (single litter and perch type) or a ‘Choice’ environment (four different litter and perch types). Immunological and behavioural indicators of birds’ coping abilities were explored at three weeks of age. Chicks from Choice environments had higher natural antibody titres, lower H/L ratios, required more attempts for tonic immobility induction and were more successful gaining novel food rewards in a repeated challenge test. Results imply that their improved natural immune response better prepared Choice chicks for coping with pathogenic challenges, that they experienced less chronic stress and were less fearful. To conclude, the increased potential for control and stimulation arising from making decisions in an early complex environment seemed to better prepare birds for a variety of challenges to come, boosting their adaptive capacities and their ability to make the most of opportunities.
Obstacles to diagnostic investigation of a child with comorbid psychiatric conditions
Authors: Salem Jena , Kennedy Cheryl 
Published: June 2021

Abstract
Presented here is the unique case of diagnostic investigation for a 16 year old male presenting in an acute state of apparent psychosis. The patient had a long history of previous specialist work-ups, tentative diagnoses, multiple emergency department admissions, and medication trials, all of which failed to produce significant lasting relief. While initial encounters diagnostically centered on autoimmune encephalitis, comprehensive work-ups always drove the differential towards a likely psychiatric disorder. Despite this consistent professional opinion, tentative diagnosis of schizophrenia with underlying Autism Spectrum Disorder was delayed for many years, due to a variety of complicating factors. Overall, this case highlights many different considerations that might assist in avoiding a protracted road to diagnosis, including navigating the obstacles that parental interaction with a complex healthcare system can pose during diagnostic evaluation and recommended treatment as well as, the role of re-interpreting past test results within the context of new literature, and the complexities of diagnosing comorbid psychiatric conditions.
Thermophysical Characteristics of Tropical Fruits in Milk Powder Products
Authors: Korotkiy Igor , Neverov Evgeniy , Vladimirov Alexander , Neverova Olga , Proskuryakova Larisa 
Published: June 2021

Introduction. Canning requires thermophysical calculations for thermal or cold processing. These calculations are based on thermophysical characteristics of raw materials. The research objective was to analyze the thermophysical characteristics of tropical fruits.
Study objects and methods. The study featured kiwi, papaya, avocado, and figs. Their thermal conductivity was analyzed with the help of stationary fiber plate method. The cryoscopic temperature was determined from the flat area of the thermogram obtained during freezing. The heat capacity and the amount of frozen moisture were determined by calculation based on the available data on the chemical composition of the fruits. The density was defined by using the hydrostatic weighing method, the sugar content – by the refractometric method, the moisture content – by drying to constant mass.
Results and discussion. The research revealed the physicochemical parameters of kiwi, avocado, papaya, and figs. Papaya demonstrated the highest moisture content – 86.32 ± 0.02%, while kiwi appeared to have the highest density – 1,065 ± 1 kg/m3. Figs had the highest sugar content – 16.0 ± 0.1%. The thermal conductivity coefficient of fresh and frozen tropical fruits was determined experimentally and increased after freezing. Frozen avocado showed only a slight increase in thermal conductivity coefficient because of its low moisture content while frozen figs demonstrated a significant increase in the thermal conductivity coefficient – by 3.3 times. This product possessed the highest thermal conductivity: 0.63 ± 0.02 W/(m·K) for the fresh samples and 2.06 ± 0.02 W/(m·K) for the frozen samples. The thermal conductivity coefficient of kiwi and papaya increased by 2 and 4.2 times, respectively. The experiment also examined the effect of protective plastic wrap and ripeness on the thermal conductivity coefficient. The film proved to have a negative effect on the reliability of thermophysical analysis. The cryoscopic temperature was determined empirically. Such thermophysical properties as heat capacity, thermal diffusivity, and frozen moisture were based on the available chemical composition.
Conclusion. The research revealed the physicochemical parameters of kiwi, avocado, papaya, and figs. It included a set of experiments on the thermal conductivity coefficient of fresh and frozen tropical fruits. The obtained values can be used to develop the optimal parameters of thermal processing, refrigeration, and thermal treatment of new products. They can also be useful for fortifying dairy and bakery products with exotic fruits.
Food Allergens and Methods for Producing Hypoallergenic Foods
Authors: Gromov Danil , Borisova Anna , Bakharev Vladimir 
Published: June 2021

Introduction. Healthy nutrition is one of the global problems that humanity is facing today, of which food safety and food allergies are the most relevant issues. A lot of chemicals used as food raw materials possess allergenic properties. Food producers are only beginning to realize the scale of this problem. As a result, hypoallergenic products and methods of food allergy prevention are at an early stage of development.
Study objects and methods. The paper is a review of twenty years of research on food allergy.
Results and discussion. The article describes the main sources of food allergens and allergenic proteins of plant and animal origin. It also gives various classifications of food allergens in terms of their stability and ability to maintain antigenic properties after processing, as well as provides methods for allergenicity reduction and hypoallergenic food production.
Conclusion. Thermal and enzymatic processing are currently the most popular methods of reducing allergenicity of food raw materials. New approaches are based on enzymatic activity of microorganisms, the chemical modification of allergenic proteins, and the removal of allergenic proteins by binding them into complexes. The combination of enzymatic processing with high hydrostatic pressure or high-intensity ultrasound is the most promising direction in the production of hypoallergenic raw materials. Other promising methods are based on the enzymatic activity of microorganisms, chemical modification of allergenic proteins, and complexation with polyphenols, anthocyanins, etc. The future lies with genetic modification, which, however, still remains too complex, time-consuming, and understudied. Most novel methods need clinical trials to confirm the possibility of their use for commercial hypoallergenic food production.
Anthocyanin Films in Freshness Assessment of Minced Fish
Authors: Chesnokova Natalya , Prikhodko Yury , Kuznetsova Alla , Kushnarenko Liudmila , Gerasimova Valeria 
Published: June 2021

Introduction. Smart food packaging that alerts consumers to spoilt food by changing color is based on affordable and biodegradable raw materials. The research objective was to develop films from anionic polysaccharides and anthocyanin pigment that can be used as a freshness indicator of minced fish.
Study objects and methods. The study featured frozen black currant berries (Ríbes nígrum), polysaccharide-based anthocyanin films, and minced fish. Extracts of anthocyanin pigment and films based on agar, kappa-carrageenan, chitosan, starch, and anthocyanin pigments were analyzed by IR spectroscopy.
Results and its discussion. Anionic polysaccharides, i.e. agar and kappa-carrageenan, demonstrated good film-forming properties. Films based on 1.5% agar and 2% kappa-carrageenan showed elasticity, resilience, plasticity, and sufficient resistance to mechanical deformation. Neutral polysaccharide starch and cationic polysaccharide chitosan appeared to have no such qualities. An IR spectral analysis revealed chemical interactions between polysaccharide and anthocyanin molecules. It indicated the electrostatic nature of the polyelectrolyte complexes of the anthocyanin pigment with anionic polysaccharides. A film based on 1.5% agar fortified with anthocyanin pigment was used as a test-system for analyzing the quality of fish. The minced fish samples were wrapped in the anthocyanin film and left for 2–7 min to register the color change of the film. When the anthocyanin film came in contact with fresh fish, the color of the film did not change even after prolonged contact. When the film came into contact with spoilt fish, the color of the film began to change after 2 min of contact. When the contact time reached 7 min, the film turned blue.
Conclusion. The type of polysaccharide and the interaction between polysaccharides and anthocyanin pigment had a significant effect on film formation. Anionic polysaccharides demonstrated the best results. Electrostatic interactions between anionic polysaccharides and anthocyanin pigments produced stable polyelectrolyte complexes. The new smart films were able to determine the quality of minced fish.
Cheese Market in Moscow and the Moscow Region: A Regional Analysis
Authors: Chebotarev Sergei , Dibrova Zhanna , Suray Natalya 
Published: June 2021

Introduction. Cheese production is a promising niche with high profitability and excellent growth prospects. The city of Moscow and the Moscow region are the largest producers of cheeses and cheese products in Russia. Cheese production is developing there as part of the import substitution policy. The article describes some promising development directions of the local cheese industry.
Study objects and methods. The paper analyzes and generalizes recent research publications, as well as regulatory and legislative documents, from legislative, statistical, and diagnostic positions.
Results and discussion. The Moscow Region ranks second in the Central Federal District in terms of gross milk production; its indicator was 700 000 tons by the end of 2020. In 2016–2020, the list of leading cheese-producing areas included the regions of Altai, Moscow, Bryansk, Belgorod, and Voronezh. In Moscow and the Moscow region, the largest share in the structure of cheese production belongs to semi-hard cheeses followed by whizzed and soft cheese, with the annual consumption of cheese of 7 kg.
Conclusion. The article features the current state of cheese market in the city of Moscow and the Moscow region, its development prospects, structure, production dynamics, consumption rate, etc. The paper also contains a forecast of the regional cheese production based on new production technologies and assortment policy.
Bioanalytical Tools in Water Quality Assessment
Authors: Escher Beate , Neale Peta , Leusch Frederic 
Published: June 2021

The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012. The field has exploded since and the second edition updates and reviews the application of bioanalytical tools for water quality assessment including surveillance monitoring. The book focuses on applications to water quality assessment ranging from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Emerging applications for other environmental matrices are also included. Bioanalytical Tools in Water Quality Assessment, Second Edition, not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment.
The book can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists and toxicologists.
Detailed descriptions of dose-response assessment, data reporting, mixture modelling and quality assurance/quality control are complemented by a series of online resources and tools to apply some of the principles and data methods explained in this book. This supplementary information is available at www.ufz.de/bioanalytical-tools.
ISBN: 9781789061970 (Paperback)
ISBN: 9781789061987 (eBook)
How are we actually doing? Comparing water and sanitation in Kenya with MDG and SDG criteria
Authors: Trepanier Lauren , Orare Josephine , Nyagwencha John , Grady Caitlin 
Published: June 2021

Abstract
This cross-sectional study assesses the extent to which water and sanitation access differs among respondents in three counties in Western and Rift Valley Kenya. By using both Millennium Development Goal (MDG) and Sustainable Development Goal (SDG) criteria, we utilize important geographical nuances of SDG water and sanitation provisioning across rural and urban settings to highlight the strengths and weaknesses of the MDGs and SDGs in each context. Purposive heterogenous sampling using local knowledge was employed to select households who represent varying rural and urban contexts with differing land use practices. Differences in water and sanitation access based on varying MDG/SDG water criteria showcase how the shift from technology-based criteria to service provisioning criteria affects understanding of progress and remaining challenges toward water and sanitation provisioning. Results indicate that although 72% of respondents have Improved Water per MDG criteria, only 34% have Safely Managed Water and 36% have Basic Water as per the SDGs. Component analyses show SDG criteria with the lowest percentages of achievement were: microbial and fluoride water quality and that sanitation facilities were not shared with other households. These results pinpoint areas where there is a need for increased research and investment surrounding how to achieve specific SDG criteria and increase access to safe water and sanitation.
Effects of core characteristics on seepage through earth dams
Authors: Abdel-Kawy Allaa O. , AboulAtta Nahla M. , El-Molla Doaa A. 
Published: June 2021

AbstractIn this research, SEEP2D and SEEP/W numerical models are used to simulate seepage through earth dams with internal cores. In order to evaluate the two models' performance, they were compared in cases with no, vertical, and wedge-shaped cores. SEEP/W was then used to study further cases due to its accuracy in drawing the phreatic line within the core zone. The effect of the core's characteristics on the amount of discharge, and the phreatic line's levels at the core's upstream and downstream faces were investigated. Four core types – vertical, wedge-shaped, upstream inclined, and downstream inclined – were considered. Different hydraulic conductivities, upper widths, and core slopes were also evaluated. The wedge-shaped core is the most effective of those investigated in reducing seepage discharge and the phreatic line's level at the core's downstream face, the vertical core came second. Design equations are provided for all the core shapes considered in the study.
Chlorination contributes to multi-antibiotic resistance in a pilot-scale water distribution system
Authors: Li Jinmei , Zhang Shuting , Guo Lizheng , Chen Lihua , Yu Zhisheng 
Published: June 2021

Abstract
The generation and dissemination of antibiotic resistance bacteria (ARB) and antibiotic resistance genes (ARGs) in the environment has become a critical risk to human health. This study is based on a pilot-scale simulated water distribution system to understand the effects of chlorine disinfection treatment (without free chlorine) on ARB and ARGs in biofilms. The hydraulic parameters and pipe materials of the system were simulated based on a drinking water system. The results of the colony counts showed that bacterial multi-antibiotic resistance could be enhanced 13-fold in the biofilms of the pipeline. The use of high-throughput qPCR (HT-qPCR) indicated that the total relative abundance of ARGs in biofilm samples increased significantly (p &lt; 0.05), while the diversity of bacteria was shown to be reduced via taxonomic analysis of the V3–V4 region of 16S rRNA. The prominent types of ARGs were conferred resistance by aminoglycoside and β-lactam after the chlorine disinfection treatment, and antibiotic deactivation was the main mechanism. Phyla Proteobacteria had the highest abundance in both treatment and control groups but decreased from 70.81% (initial biofilm sample) to 26.09% (the sixth-month biofilm sample) in the treatment groups. The results show that the chlorine disinfection plays a role in the risk of development of bacterial antibiotic resistance in pipe networks owing to bacteria in biofilms. This study was the first to investigate the contribution of chlorination without free chlorine to the bacterial community shift and resistome alteration in biofilms at a pilot-test level.
Targeting Bacterial Membrane Proteins to Explore the Beneficial
Effects of Natural Products: New Antibiotics against Drug Resistance
Authors: Huang Piying , Wang Zhe , Cai Kun , Wei Liangwan , Chu Yindi , Guo Mingquan , Fan Enguo 
Published: June 2021

:
Antibiotic resistance is currently a world health crisis that urges the development of
new antibacterial substances. To this end, natural products, including flavonoids, alkaloids,
terpenoids, steroids, peptides and organic acids play a vital role in the development of medicines
and thus constitute a rich source in clinical practices, providing an important source of
drugs directly or for the screen of lead compounds for new antibiotic development. Because
membrane proteins, which comprise more than 60% of the current clinical drug targets, play
crucial roles in signal transduction, transport, bacterial pathogenicity and drug resistance, as
well as immunogenicity, it is our aim to summarize those natural products with different
structures that target bacterial membrane proteins, such as efflux pumps and enzymes, to provide
an overview for the development of new antibiotics to deal with antibiotic resistance.
Thioethers: An Overview
Authors: Han M. İhsan , Küçükgüzel Ş. Güniz 
Published: June 2021

:
Spreading rapidly in recent years, cancer has become one of the causes of the highest mor-tality rates after cardiovascular diseases. The reason for cancer development is still not clearly under-stood despite enormous research activities in this area. Scientists are now working on the biology of cancer, especially on the root cause of cancer development. The aim is to treat the cancer disease and thus cure the patients. The continuing efforts for the development of novel molecules as potential anti-cancer agents are essential for this purpose. The main aim of this review was to present a survey on the medicinal chemistry of thioethers and provide practical data on their cytotoxicities against various cancer cell lines. The research articles published between 2001-2020 were consulted to pre-pare this review article; however, patent literature has not been included. The thioether-containing heterocyclic compounds may emerge as a new class of potent and effective anti-cancer agents in the future.
Combination Therapy as a Strategy to Control Infections Caused by
Multi-resistant Bacteria: Current Review
Authors: Hernandez-Rodriguez Patricia , Baquero Ludy P. 
Published: June 2021

:
Antimicrobial Resistance (AMR) is one of the main challenges of today's medicine because
it has become a global problem that affects the treatment of multiple infections and impacts
public health. This resistance is caused as the bacteria generate selective pressure-promoting
mechanisms to evade the action of conventional drugs, which are also associated with adverse
effects. Infections caused by these multi-resistant bacteria potentially reduce the possibility of effective
therapy; this situation increases morbidity and mortality and treatment costs. Therefore, to
establish combined therapy as a strategy for the control of infections caused by multi-resistant bacteria,
a bibliographic search was carried out between 2015 and 2020 in databases such as PubMed,
Scopus and Science Direct. The exhaustive review of the articles allowed a critical analysis of the
information. Mechanisms were identified for obtaining drugs with antimicrobial potential, their biological
activity and the possible effect of their combination against multidrug-resistant bacteria as
an alternative for infectious disease control and as a response to reduce the use of antibiotics. Combined
therapy is presented as an innovative therapeutic alternative, which uses non-antibiotic substances
that can be obtained by three routes: the repositioning of drugs, synthetic substances and natural
products. In this way, important elements are provided to guide researches that seek to reduce
antimicrobial resistance.