bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intuitive and mindful eating to improve physiological health parameters: a short narrative review of intervention studies
Authors: Hayashi Lauren C. , Benasi Giada , St-Onge Marie-Pierre , Aggarwal Brooke 
Published: December 2021

Abstract

Objectives
This brief narrative review aims to give an up-to-date overview of intuitive and mindful eating (I/ME) interventions with specific focus on cardiometabolic risk factors, including glucose, lipid profile, blood pressure and inflammatory markers.

Content
I/ME intervention studies in adults which measured at least one physiological parameter other than weight were identified from PubMed. The clinical trial/randomized controlled trial filters and publication dates 2001 through April 2021 with variations of the following keywords were applied: intuitive eating, mindful eating, weight neutral. Ten articles were identified.

Summary and outlook
Of the 10 studies, seven showed I/ME interventions were more effective than control in at least one cardiometabolic outcome, two showed significant I/ME within-group improvements but no between-group differences, and one showed neither within-group nor between-group differences. Specifically, I/ME improved glucose levels among pregnant women with or without gestational diabetes, lipid profile among adults with overweight or obesity, blood pressure among participants with overweight and inflammatory markers among post-menopausal women with obesity. However, the positive impact of I/ME on each of these cardiometabolic parameters was not consistent across studies: of the six studies that examined glucose regulation, two demonstrated positive outcomes for I/ME group, whereas four found no effect compared to control. Three out of five studies had positive lipid effects, one out of five demonstrated systolic blood pressure (SBP) improvements and one of two showed improvements in inflammatory markers. Given these mixed results, more research is needed to understand the possible effectiveness of I/ME to improve cardiometabolic health.
A Review of epigenetics in psychiatry: focus on environmental risk factors
Authors: Keverne Jessica , Binder Elisabeth B. 
Published: December 2021

Abstract
Epigenetic modifications play a key role in development and cell type specificity. These modifications seem to be particularly critical for brain development, where mutations in epigenetic enzymes have been associated with neurodevelopmental disorders as well as with the function of post-mitotic neurons. Epigenetic modifications can be influenced by genetic and environmental factors, both known major risk factors for psychiatric disorders. Epigenetic modifications may thus be an important mediator of the effects of genetic and environmental risk factors on cell function.
This review summarizes the different types of epigenetic regulation and then focuses on the mechanisms transducing environmental signals, especially adverse life events that are major risk factors for psychiatric disorders, into lasting epigenetic changes. This is followed by examples of how the environment can induce epigenetic changes that relate to the risk of psychiatric disorders.
Combating the SARS-CoV-2 pandemic: How can the field of Human Genetics contribute?
Authors: Ludwig Kerstin U. , Schmidt Axel , Hoffmann Per , Nöthen Markus M. 
Published: December 2021

AbstractThe ongoing SARS-CoV-2 pandemic has triggered several months of global turmoil, and governments across the world are now actively attempting to develop strategies to combat both the virus and its societal impact. Since SARS-CoV-2 is a novel pathogen, basic research is essential, and manifold international efforts are now underway in order to elucidate the molecular mechanisms of both the SARS-CoV-2 infection process and the resulting disease, COVID-19. In this article we discuss how the field of Human Genetics can contribute to this endeavor, and summarize available findings from human genetic COVID-19 research. Finally, we briefly outline how through the use of existing national research infrastructure, German scientists can facilitate progress in this novel and fast-moving field.
Charcot-Marie-Tooth neuropathy and pregnancy: general and specific issues
Authors: Rudnik-Schöneborn Sabine , Elbracht Miriam 
Published: December 2021

Abstract

Background:
Charcot-Marie-Tooth (CMT) neuropathies represent an important group of neuromuscular disorders and are mostly autosomal dominantly inherited. The question, if there is a higher complication rate in pregnancy and delivery in CMT neuropathy and if there is a possible influence of pregnancy on muscles and nerves themselves, is important for medical care and prepregnancy counselling of affected women.

Objectives:
In this review we first address general issues of the clinical picture of CMT disease and physiological adaptations in pregnancy. In the second part of this paper we summarise specific results of two comparable studies on the obstetric history of women with CMT neuropathy in order to address the obstetric complication rate, newborn vitality, possible deterioration of CMT in or after pregnancy and personal attitudes. The results are based on two combined cohort studies with 21 and 54 participants.

Results:
We documented 148 pregnancies (129 deliveries), resulting in 131 infants. There were no increased complication rates in the recorded pregnancies. Miscarriage rate was 12.8 % and thus as high as in unaffected women. Deliveries were not associated with specific risks; there were no increased preterm deliveries, vaginal operations or caesarean sections, and no increased postpartum haemorrhages. Newborn vitality was normal and birth measurements were within the normal range. A deterioration of CMT related symptoms was reported in about one-third of the pregnancies and after delivery, however, the functional impact on everyday life was rather low in classical CMT. Most women expressed a positive attitude towards having own children and family life but those with a larger handicap would recommend medical advice and assistance in caring for the family.

Discussion and conclusion:
Pregnancy can be safely undertaken in women with classical CMT, despite the fact that a negative influence on the disease course appears possible. The data of a Norwegian study which found higher rates of presentation anomalies and operative deliveries and a higher risk of postpartum haemorrhage have not been confirmed in our study.
Der Weg in die Einheit: Das Fach Humangenetik 1990–1991. Ein Erfahrungsbericht
Authors: Passarge Eberhard , Sperling Karl , Theile Herbert 
Published: December 2021

Zusammenfassung
Die Vereinigung der beiden deutschen Staaten vor dreißig Jahren am 3. Oktober 1990 ermöglichte auch eine Vereinigung der getrennt existierenden Gesellschaft für Humangenetik (GfH) der Bundesrepublik Deutschland und der Gesellschaft für Humangenetik der DDR. Dieser Beitrag beschreibt auf Basis des eigenen Erlebens, wie im Fach Humangenetik die Trennung in Ost und West überwunden wurde. Innerhalb eines Jahres konnte die Einheit herbeigeführt werden. Dabei waren Schwierigkeiten zu überwinden, da eine einfache Fusion aus vereinsrechtlichen Gründen nicht möglich war. Dennoch war im Jahr 1991 die Zusammenführung vollendet.
What can go wrong in the non-coding genome and how to interpret whole genome sequencing data
Authors: Krude Heiko , Mundlos Stefan , Øien Nancy Christine , Opitz Robert , Schuelke Markus 
Published: December 2021

Abstract
Whole exome sequencing discovers causative mutations in less than 50 % of rare disease patients, suggesting the presence of additional mutations in the non-coding genome. So far, non-coding mutations have been identified in less than 0.2 % of individuals with genetic diseases listed in the ClinVar database and exhibit highly diverse molecular mechanisms. In contrast to our capability to sequence the whole genome, our ability to discover and functionally confirm such non-coding mutations is lagging behind severely. We discuss the problems and present examples of confirmed mutations in deep intronic sequences, non-coding triplet repeats, enhancers, and larger structural variants and highlight their proposed disease mechanisms. Finally, we discuss the type of data that would be required to establish non-coding mutation detection in routine diagnostics.
Technologies for profiling the impact of genomic variants on transcription factor binding
Authors: Leiz Janna , Rutkiewicz Maria , Birchmeier Carmen , Heinemann Udo , Schmidt-Ott Kai M. 
Published: December 2021

Abstract
Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby regulate target gene expression. TF binding and its regulatory activity is highly context dependent, and is not only determined by specific cell types or differentiation stages but also relies on other regulatory mechanisms, such as DNA and chromatin modifications. Interactions between TFs and their DNA binding sites are critical mediators of phenotypic variation and play important roles in the onset of disease. A continuously growing number of studies therefore attempts to elucidate TF:DNA interactions to gain knowledge about regulatory mechanisms and disease-causing variants. Here we summarize how TF-binding characteristics and the impact of variants can be investigated, how bioinformatic tools can be used to analyze and predict TF:DNA binding, and what additional information can be obtained from the TF protein structure.
Geschichtsbewusstsein und historische Verantwortung in der deutschen Humangenetik
Authors: Krischel M. , Fangerau H. , Söhner F. 
Published: December 2021

Zusammenfassung
Historiker*innen haben immer wieder auf personelle und institutionelle Kontinuitäten zwischen der Eugenik in Deutschland vor 1945 und der sich entwickelnden Humangenetik im Nachkriegsdeutschland hingewiesen. Wie aber wurde diese äußere Wahrnehmung unter deutschen Humangenetiker*innen diskutiert und spielte sie für das Selbstbild der Disziplin eine Rolle? Auf der Basis von gedruckten Quellen und biographischen Interviews wurden das Geschichtsbewusstsein und die Übernahme historischer Verantwortung unter deutschen Humangenetiker*innen untersucht, die in der Zeit zwischen den 1970er und den 2010er Jahren im Feld tätig waren. Ein historisches Bewusstsein spielte in der Erinnerung der Zeitzeug*innen schon vor den 1980er Jahren eine Rolle für ihr Fach und seit der Gründung der Deutschen Gesellschaft für Humangenetik im Jahr 1987 wird in der Gesellschaft die Frage der Form einer historischen Verantwortungsübernahme immer wieder diskutiert. Sie findet ihren praktischen Ausdruck z. B. in Diskussionen mit der Öffentlichkeit und in der Umbenennung von Preisen.
Television Series as Critical Theories: From Current Identitarianism to Levinas. American Crime, The Sinner, Sharp Objects, Unorthodox
Authors: Corcuff Philippe 
Published: December 2021

Abstract
Critical theory with emancipatory aims today to find a source of regeneration in ordinary cultures, and in particular, in TV series. Certain series can play a role in reinventing critical theories, drawing on the tradition of the Frankfurt School but shifting some of that School’s formulations through contact with current forms of interpretive sociology and pragmatic sociology. This requires a cross-border dialogue between the “language game” of TV series and the “knowledge game” of political theory, to use concepts inspired by Ludwig Wittgenstein. In this article, I will focus on four series: seasons 1 of American Crime (2015) and The Sinner (2017); Sharp Objects (2018); and Unorthodox (2020). The resources provided by these cultural works can help us formulate a critical decoding of important aspects of the current ideological context, in particular, the intersecting identitarian and ultra-conservative tendencies we find in France, Europe, the United States, and Brazil. These critical resources bear affinities to a political philosophy of the opening of being inspired by the ethical reflections of Emmanuel Levinas.
The effect of second order slip condition on MHD nanofluid flow around a semi-circular cylinder
Authors: Cao Jiahui , Zhu Jing , Si Xinhui , Li Botong 
Published: December 2021

Abstract
Steady forced convection of non-Newtonian nanofluids around a confined semi-circular cylinder subjected to a uniform magnetic field is carried out using ANSYS FLUENT. The numerical solution is obtained using the finite volume method. The user-defined scalar (UDS) is used for the first time to calculate the second order velocity slip boundary condition in semi-circular curved surface and the calculated results are compared with those of the first order velocity slip boundary condition. Besides, the effects of volume fraction, size, type of nanoparticles and magnetic field strength on heat transfer are studied. The present study displays that adding nanoparticles in non-Newtonian fluids significantly enhances heat transfer. In addition, it is observed that the heat transfer rate decreases first and then increases with the increase of Hartmann number. The effects of blocking rate on Nusselt number, wake length and heat transfer effect are shown in the form of graphs or tables.
Strategy to Improve The Competitiveness of Cooperatives
Authors: Rusdarti Rusdarti , Sakitri Wijang 
Published: December 2021

This research purposes is to analyze cooperativeâ€™s strategy to improve its competitiveness based on information technology utilization. This research employs a quantitative descriptive approach, analysis on cooperative competitiveness with Policy Analysis Matrix (PAM) in consideration of input and output. Cooperativeâ€™s business development strategy employs an analytic hierarchy process (AHP). The analysis is conducted on active cooperatives with open data system (ODS) in Central Java Province. 64.82% of all cooperatives have utilized information technology in their business operation and 35.18% of all cooperatives have not utilized information technology in their business operation; Result of the Policy Analysis Matrix (PAM) using the Domestic Resources Cost Ratio (DRC) = 0.240 This Condition shows that the cooperatives business is efficient and has comparative advatage.Â Private Cost Ratio (PCR) = 0.229, means the cooperative has been able to use its domestic use the actual price and has competitive advantage. Cooperative has comparative advantage and competitive advantage competitiveness. The results of AHP analysis with five development criteria show that the information technology criterion is the most prioritized criterion with weight value of 0.365; the capital criterionâ€™s weight value is 0.218; the human resource criterionâ€™s weight value is 0.195; the network criterionâ€™s weight value is 0.164, and the marketing criterionâ€™s weight value is 0.058. The cooperative competitiveness standard does not include export variable, thus further research needs to be conducted with different measuring tool from that of this research.
Implementation of The Effectiveness of Regional Autonomy in Indonesia
Authors: Aminah Aminah , Gantyowati Evi , Winarna Jaka , Khairudin Khairudin , Redaputri Appin Purisky 
Published: December 2021

The drive of this study is to postulate empirical evidence about the evaluation of the enactment of regional autonomy in Indonesia after the enactment of Act Number 22 Year 1999 concerning Regional Government. Exclusively, this analysis aims to evaluate the wellbeing of the community, public services and regional competitiveness in the new autonomous regions. This research was conducted in 71 new autonomous regions in the Sumatra region after the depiction of Act Number 22 of 1999 concerning Regional Government during the 2000-2018 period.Â This type of research uses quantitative research. While the research method used is descriptive method, which is a research method that describes the population under study and consists of variables. The results of the study found that (1) the success rate of implementing regional autonomy for 20 years in the Sumatra region from the welfare aspect was 64.78%, meaning that the implementation of regional autonomy in the Sumatra region so far (64.78%) "has succeeded in increasing the HDI" according to the mandate of the law; (2) the level of success in implementing regional autonomy for 20 years in the Sumatra region from the aspect of regional competitiveness is 18.30%. The conclusion is that the implementation of regional autonomy in the Sumatra region has not been sufficiently successful in increasing regional competitiveness in terms of GRDP; (3) Riau Province is a region that has been very successful in implementing regional autonomy both in terms of welfare and regional competitiveness.
Factors Affecting the Composite Stock Price Index during Covid-19 Pandemic Crisis
Authors: Hidayat Ariodillah , Liliana Liliana , Andaiyani Sri 
Published: December 2021

This paper aims to analyze factors affecting the Composite Stock Price Index (IHSG) on the Jakarta Stock Exchange (IDX) during the Pademi Corona Crisis. This study uses the multiple linear regression analysis technique where the variable number of confirmed Covid-19 cases in the world, the number of confirmed Covid-19 cases in Indonesia, the Rupiah exchange rate per 1 US dollar, and the world crude oil price are used as independent variables (X) and the IHSG as the dependent variable (Y), the data used in this study are weekly time series data from the period December 2019 to September 2020. Based on the results of variable regression between the IHSG, Exchange Rates, Oil Prices, cases of COVID-19 in Indonesia and COVID-19 World, It is concluded that collectively the independent variables have a significant effect on the IHSG. Partially, Oil Prices, COVID-19 cases in Indonesia and COVID-19 cases in the world have a significant effect on the IHSG. Meanwhile, the exchange rate has no significant effect on the IHSG.
The Impact of Climate Change on Economic Conditions: Evidence in Indonesia
Authors: Febriandika Nur Rizqi , Rahayu Cahyaningtiyas 
Published: December 2021

Climate change has consequences and influences on agricultural productivity, especially in tropical areas such as Indonesia. Agricultural produce contributes to the level of Gross Domestic Product. Climate change is a challenge for the environment that has the most extensive impact on the economic, natural resources, and agricultural sectors, even as a concern for climate change on agricultural production. So it is needed to discuss climate change which has an impact on various sectors, especially the economic sector. This research was carried out during 2016-2018 using all provinces in Indonesia. This study uses panel data regression method, and the chosen model is the Fixed Effect Model (FEM) by displaying the effects of each region. The results of this study show that R-squared value is 0.990095 which means that 99% of independent variables collectively determine the value of GDP. Meanwhile, changes in temperature, increased rainfall, and increased air quality index partially have no effect on GDP. Only the extent of agricultural land area partially has a positive effect on GDP.
Public Behaviour on Cash Waqf: Evidence from Indonesia
Authors: Haidlir Banu M , Laksmono Bambang S , Kasri Rahmatina A , Azizon Azizon , Hartono Djoni 
Published: December 2021

Despite the potential governmental agenda towards cash waqf, this area has been givessn limited attention in academic literature with special regards to the supply side. Therefore, this study aims to investigate the factors influencing the public intention in endowing cash waqf by utilizing an extended theory of planned behaviors (TPB); in which religiosity, knowledge, and trust variables are added. Primary data from 685 respondents in Indonesia are analyzed using structural equation modeling (SEM). The result showed that the intention to endow cash waqf is positively affected by all of the TPB variables (attitude, subjective norms, and perceived behavioral control) and other extended variables. The findings suggest an optimization in waqf fund collection and waqf fund management. For waqf collection, it is important to improve public literacy and the quality and quantity of supporting facilities and systems. Meanwhile, institutional management should be strengthened for waqf management.
A survey of machine learning techniques for detecting and diagnosing COVID‐19 from imaging
Authors: Panday Aishwarza , Kabir Muhammad Ashad , Chowdhury Nihad Karim 
Published: December 2021

BackgroundDue to the limited availability and high cost of the reverse transcription‐polymerase chain reaction (RT‐ PCR) test, many studies have proposed machine learning techniques for detecting COVID‐19 from medical imaging. The purpose of this study is to systematically review, assess and synthesize research articles that have used different machine learning techniques to detect and diagnose COVID‐19 from chest X‐ray and CT scan images.MethodsA structured literature search was conducted in the relevant bibliographic databases to ensure that the survey solely centered on reproducible and high‐quality research. We selected papers based on our inclusion criteria.ResultsIn this survey, we reviewed 98 articles that fulfilled our inclusion criteria. We have surveyed a complete pipeline of chest imaging analysis techniques related to COVID‐19, including data collection, pre‐processing, feature extraction, classification, and visualization. We have considered CT scans and X‐rays as both are widely used to describe the latest developments in medical imaging to detect COVID‐19.ConclusionsThis survey provides researchers with valuable insights into different machine learning techniques and their performance in the detection and diagnosis of COVID‐19 from chest imaging. At the end, the challenges and limitations in detecting COVID‐19 using machine learning techniques and the future direction of research are discussed.
The electronic states of ITO–MoS2: Experiment and theory
Authors: López-Galán Oscar A. , Ramos Manuel , Nogan John , Ávila-García Alejandro , Boll Torben , Heilmaier Martin 
Published: December 2021

AbstractWe report a combination of experimental results with density functional theory (DFT) calculations to understand electronic structure of indium tin oxide and molybdenum disulfide (ITO–MoS2) interface. Our results indicate ITO and MoS2 conform an n-type Schottky barrier of c.a. − 1.0 eV due to orbital interactions; formation of an ohmic contact is caused by semiconducting and metal behavior of ITO as a function of crystal plane orientation. ITO introduces energy levels around the Fermi level in all interface models in the Γ-Μ-Κ-Γ path. The resulted Van der Waals interface and the values of Schottky barrier height enhance electron carrier injection.
Graphical abstract