bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclophosphamide-Free Adjuvant Chemotherapy for Ovarian Protection in Young Women With Breast Cancer: A Randomized Phase 3 Trial
Authors: Yu Ke-Da , Ge Jing-Yu , Liu Xi-Yu , Mo Miao , He Min , Shao Zhi-Ming ,   SPECTRUM Investigators
Published: April 2021

Abstract

Background
Chemotherapy-induced premature menopause leads to some consequences, including infertility. We initiated this randomized phase III trial to determine whether a cyclophosphamide-free adjuvant chemotherapy regimen would increase the likelihood of menses resumption and improve survival outcomes.

Methods
Young women with operable estrogen receptor-positive HER2-negative breast cancer after definitive surgery were randomly assigned to receive adjuvant epirubicin and cyclophosphamidefollowed by weekly paclitaxel (EC-wP) or epirubicin and paclitaxel followed by weekly paclitaxel (EP-wP). All patients received at least 5-year adjuvant endocrine therapy after chemotherapy. Two coprimary endpoints were the rate of menstrual resumption at 12 months after chemotherapy and 5-year disease-free survival in the intention-to-treat population. This study is registered at ClinicalTrials.gov (NCT01026116). All statistical tests were 2-sided.

Results
Between January 2011 and December 2016, 521 patients (median age = 34 years; interquartile range = 31-38 years) were enrolled, with 261 in the EC-wP group and 260 in the EP-wP group. The rate of menstrual resumption at 12 months after chemotherapy was 48.3% in EC-wP (95% confidence interval [CI] = 42.2% to 54.3%) and 63.1% in EP-wP (95% CI = 57.2% to 68.9%), with an absolute difference of 14.8% (95% CI = 6.37% to 23.2%, P &lt; .001). The posthoc exploratory analysis by patient-reported outcome questionnaires indicated that pregnancy might occur in fewer women in the EC-wP group than in the EP-wP group. At a median follow-up of 62 months, the 5-year disease-free survival was 78.3% (95% CI = 72.2% to 83.3%) in EC-wP and 84.7% (95% CI = 79.3% to 88.8%) in EP-wP (stratified log-rank P = .07). The safety data were consistent with the known safety profiles of relevant drugs.

Conclusions
The cyclophosphamide-free chemotherapy regimen might be associated with a higher probability of menses resumption.
The competition possibility between renewable energy and fossil energy in Vietnam in the future
Authors: Minh Thong Le , Van Hiep Tran , Thi Thu Thuy Bui , Huu Tung Do 
Published: April 2021

ABSTRACT
With high economic growth, Vietnam is now witnessing an increasing energy demand, having much potential for renewable sources such as wind energy, solar energy or biomass energy. The nation is heavily dependent on fossil energy sources such as coal and oil. This situation raises concerns about both energy security and the environment. Therefore, a question arises if Vietnam can develop renewable energy to solve energy demand, energy security and reduce climate change impacts as committed. This article analyses a considerable potential for renewable energy sources (especially wind and solar energy). The analysis also indicates competitiveness between these renewable energy sources compared to the traditional energy sources that Vietnam is dependent on, especially when there are policies to encourage the development of renewable energy and limit emissions. This article proposes some recommendations to develop renewable energy sources, with an overview of replacing fossil energy in Vietnam.
A better mousetrap to guard against anthracnose disease in bean
Authors: Cannon Steven B , Innes Roger W 
Published: April 2021

This article comments on:
Richard MSM, Gratias A, Alvarez Diaz JC, Thareau V, Pflieger S, Meziadi C, Blanchet S, Marande W, Bitochi E, Papa R, Miklas PN, Geffroy V. 2021. A common bean truncated CRINKLY4 kinase controls gene-for-gene resistance to the fungus Colletotrichum lindemuthianum. Journal of Experimental Botany 72, 3569–3581.
Plant signals differentially affect rhizosphere nematode populations
Authors: Mathesius Ulrike , Costa Sofia R 
Published: April 2021

This article comments on:
Sikder MM, Vestergård M, Kyndt T, Fomsgaard IS, Kudjordjie EN, Nicolaisen M. 2021. Benzoxazinoids selectively affect maize root-associated nematode taxa. Journal of Experimental Botany 72,3835–3845.
Epistemic extensions of substructural inquisitive logics
Authors: Punčochář Vít , Sedlár Igor 
Published: April 2021

AbstractIn this paper, we study the epistemic extensions of distributive substructural inquisitive logics. Substructural inquisitive logics are logics of questions based on substructural logics of declarative sentences. They generalize basic inquisitive logic which is based on the classical logic of declaratives. We show that if the underlying substructural logic is distributive, the generalization can be extended to embrace also the epistemic modalities ‘knowing whether’ and ‘wondering whether’ that are applicable to questions. We construct a semantic framework for a language of propositional substructural logics enriched with a question-forming operator (inquisitive disjunction) and epistemic modalities. We show that within this framework, one can define a canonical model with suitable properties for any (syntactically defined) epistemic inquisitive logic. This leads to a general approach to completeness proofs for such logics. A deductive system for the weakest epistemic inquisitive logic is described and completeness proved for this special case using the general method.
Cosmological bulk flow in the QCDM model: (in)consistency with ΛCDM
Authors: Salehi A , Yarahmadi M , Fathi S , Bamba Kazuharu 
Published: April 2021

ABSTRACT
We study the bulk flow of the local universe with Type Ia supernova data (a compilation of Union2 and Pantheon data) in the spatially flat homogeneous and isotropic space–time. In particular, we take the so-called QCDM models, which consist of cold dark matter (CDM) and a Q-component described by a scalar field with its self-interactions determined by an exponential potential. We use different cumulative redshift slices of the Union2 and Pantheon catalogues. A maximum-likelihood analysis of peculiar velocities confirms that, at low redshifts 0.015 &lt; z &lt; 0.1, the bulk flow is moving in the $l=272^{+17}_{-17}, b=33^{+12}_{-12}$, and $302^{+20}_{-20},3^{+10}_{-10}$ directions with $v _\mathrm{bulk} = 225^{+38}_{-35}$ and $246^{+64}_{-46}$ km s−1 for the Pantheon and Union2 data respectively, in good agreement with the direction of the cosmic microwave background dipole and with a number of previous studies at 1σ. However, for high redshifts 0.1 &lt; z &lt; 0.2, we get $v _\mathrm{bulk} = 708^{+110}_{-110}$ and $v_\mathrm{bulk}=1014^{+86}_{-114}\,\text{km\,s}^{-1}$ towards l = 318 ± 10°, b = −15 ± 9° and $l=254^{+16}_{-14},\ b=6^{+7}_{-10}$ for the Pantheon and Union2 data respectively. This indicates that for low redshifts our results are approximately consistent with the ΛCDM model; however, for high redshifts they disagree with ΛCDM and support the results of those studies that report a large bulk flow for the universe.
On the AGN nature of broad balmer emission in four low-redshift metal-poor galaxies
Authors: Burke Colin J , Liu Xin , Chen Yu-Ching , Shen Yue , Guo Hengxiao 
Published: April 2021

ABSTRACT
We report on continued, ∼15-yr long, broad Balmer emission lines in three metal-poor dwarf emission-line galaxies selected from Sloan Digital Sky Survey spectroscopy. The persistent luminosity of the broad Balmer emission indicates the galaxies are active galactic nuclei (AGNs) with virial black hole masses of ∼106.7–107.0 M⊙. The lack of observed hard X-ray emission and the possibility that the Balmer emission could be due to a long-lived stellar transient motivated additional follow-up spectroscopy. We also identify a previously unreported blueshifted narrow absorption line in the broad H α feature in one of the AGNs, indicating an AGN-driven outflow with hydrogen column densities of order 1017 cm−2. We also extract light curves from the Catalina Real-Time Transient Survey and the Zwicky Transient Facility. We detect probable AGN-like variability in three galaxies, further supporting the AGN scenario. This also suggests the AGNs are not strongly obscured. This sample of galaxies are among the most metal-poor that host an AGN (Z = 0.05–0.16 Z⊙). We speculate they may be analogues to seed black holes which formed in unevolved galaxies at high redshift. Given the rarity of metal-poor AGNs and small sample size available, we investigate prospects for their identification in future spectroscopic and photometric surveys.
Three ultraluminous X-ray sources hosted by globular clusters in NGC 1316
Authors: Dage Kristen C , Kundu Arunav , Thygesen Erica , Bahramian Arash , Haggard Daryl , Irwin Jimmy A , Maccarone Thomas J , Nair Sneha , Peacock Mark B , Strader Jay , Zepf Stephen E 
Published: April 2021

ABSTRACT
We have identified three ultraluminous X-ray sources (ULXs) hosted by globular clusters (GCs) within NGC 1316’s stellar system. These discoveries bring the total number of known ULXs in GCs up to 20. We find that the X-ray spectra of the three new sources do not deviate from the established pattern of spectral behaviour of the other known GC ULXs. The consistency of the X-ray spectral behaviour for these sources points to multiple paths of formation and evolution mechanisms for these rare and unique sources. Using the now larger sample of GC ULXs, we compare the optical properties of the entire known population of GC ULXs to other GCs across five galaxies and find that the properties of clusters that host ULXs are quite different from the typical clusters. Lastly, any trend of GC ULXs being preferentially hosted by metal-rich clusters is not strongly significant in this sample.
Systematic uncertainties in models of the cosmic dawn
Authors: Mirocha Jordan , Lamarre Henri , Liu Adrian 
Published: April 2021

ABSTRACT
Models of the reionization and reheating of the intergalactic medium (IGM) at redshifts z ≳ 6 continue to grow more sophisticated in anticipation of near-future 21-cm, cosmic microwave background, and galaxy survey measurements. However, there are many potential sources of systematic uncertainty in models that could bias and/or degrade upcoming constraints if left unaccounted for. In this work, we examine three commonly ignored sources of uncertainty in models for the mean reionization and thermal histories of the IGM: the underlying cosmology, halo mass function (HMF), and choice of stellar population synthesis (SPS) model. We find that cosmological uncertainties affect the Thomson scattering optical depth at the few per cent level and the amplitude of the global 21-cm signal at the ∼5–10 mK level. The differences brought about by choice of HMF and SPS models are more dramatic, comparable to the 1σ error bar on τe and an ∼20 mK effect on the global 21-cm signal amplitude. Finally, we jointly fit galaxy luminosity functions and global 21-cm signals for all HMF/SPS combinations and find that (i) doing so requires additional free parameters to compensate for modelling systematics and (ii) the spread in constraints on parameters of interest for different HMF and SPS choices, assuming 5 mK noise in the global signal, is comparable to those obtained when adopting the 'true' HMF and SPS with ≳20 mK errors. Our work highlights the need for dedicated efforts to reduce modelling uncertainties in order to enable precision inference with future data sets.
Structural variation affecting DNA backbone interactions underlies adaptation of B3 DNA binding domains to constraints imposed by protein architecture
Authors: Jia Haiyan , Suzuki Masaharu , McCarty Donald R 
Published: April 2021

Abstract
Functional and architectural diversification of transcription factor families has played a central role in the independent evolution of complex development in plants and animals. Here, we investigate the role of architectural constraints on evolution of B3 DNA binding domains that regulate plant embryogenesis. B3 domains of ABI3, FUS3, LEC2 and VAL1 proteins recognize the same cis-element. Complex architectures of ABI3 and VAL1 integrate cis-element recognition with other signals, whereas LEC2 and FUS3 have reduced architectures conducive to roles as pioneer activators. In yeast and plant in vivo assays, B3 domain functions correlate with architectural complexity of the parent transcription factor rather than phylogenetic relatedness. In a complex architecture, attenuated ABI3-B3 and VAL1-B3 activities enable integration of cis-element recognition with hormone signaling, whereas hyper-active LEC2-B3 and FUS3-B3 over-ride hormonal control. Three clade-specific amino acid substitutions (β4-triad) implicated in interactions with the DNA backbone account for divergence of LEC2-B3 and ABI3-B3. We find a striking correlation between differences in in vitro DNA binding affinity and in vivo activities of B3 domains in plants and yeast. Our results highlight the role of DNA backbone interactions that preserve DNA sequence specificity in adaptation of B3 domains to functional constraints associated with domain architecture.
DELLA degradation by gibberellin promotes flowering via GAF1-TPR-dependent repression of floral repressors in Arabidopsis
Authors: Fukazawa Jutarou , Ohashi Yuki , Takahashi Ryuhei , Nakai Kanako , Takahashi Yohsuke 
Published: April 2021

Abstract
Flowering is the developmental transition from the vegetative to the reproductive phase. FLOWERING LOCUS T (FT), SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1), and LEAFY (LFY) are floral integrators. These genes are repressed by several floral repressors including EARLY FLOWERING3 (ELF3), SHORT VEGETATIVE PHASE (SVP), TEMPRANILLO1 (TEM1), and TEM2. Although gibberellin (GA) promotes flowering by activating the floral integrator genes, the exact molecular mechanism remains unclear. DELLAs are negative regulators in GA signaling and act as coactivators of the transcription factor GAI ASSOCIATED FACTOR 1 (GAF1). GAs convert the GAF1 complex from a transcriptional activator to a repressor. Here, we show that GAF1 functions in the GA-dependent flowering pathway by regulating FT and SOC1 expression in Arabidopsis thaliana. We identified four flowering repressors, ELF3, SVP, TEM1, and TEM2, as GAF1-target genes. In response to GAs, GAF1 forms a transcriptional repressor complex and promotes the expression of FT and SOC1 through the repression of four flowering repressor genes, ELF3, SVP, TEM1, and TEM2.
Efficacy of Anodal Suboccipital Direct Current Stimulation for Endogenous Pain Modulation and Tonic Thermal Pain Control in Healthy Participants: A Randomized Controlled Clinical Trial
Authors: García-Barajas Guillermo , Serrano-Muñoz Diego , Gómez-Soriano Julio , Avendaño-Coy Juan , Fernández-Carnero Josue , Megía García Alvaro , Segura-Fragosa Antonio , Taylor Julian 
Published: April 2021

Abstract

Objective
The aim of this study was to assess whether anodal DCS applied to the suboccipital (SO) target area could potentiate antinociception assessed primarily with conditioned pain modulation of tonic thermal test stimuli.

Design
Randomized double-blinded control trial.

Setting
Rehabilitation hospital.

Subjects
Healthy participants.

Methods
Forty healthy participants were randomized to receive either SO-DCS or M1-DCS. The 20-minute 1.5 mA anodal or sham DCS intervention were applied to each participant in randomized order during two test sessions. The primary outcome measure included heterotopic cold-pressor conditioned pain modulation (CPM) of tonic heat pain. Secondary measures included pressure pain threshold and tonic thermal pain intensity.

Results
Heterotopic CPM of tonic heat pain intensity was unaffected by either SO-DCS or active M1, including the secondary measures of pressure pain threshold and tonic thermal pain intensity. Although low-power non-significant interactions were identified for DCS intervention (active versus sham) and time (before and after), a significant within-group inhibition of tonic cold pain was identified following SO-DCS (P = .011, mean [SD]: −0.76 ± 0.88 points) and M1-DCS (P &lt; .002: −0.84 ± 0.82 points), without a significant change following sham DCS.

Conclusions
Although heterotopic CPM was not facilitated with either SO-DCS or M1-DCS, a general significant inhibition of tonic cold pain intensity was demonstrated following both interventions. The general effects of active DCS compared to sham on tonic cold pain—irrespective of the M1 or SO target—need to be confirmed using standard quantitative sensory testing.
Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12
Authors: Toyoda Yu , Kawamura Yusuke , Nakayama Akiyoshi , Nakaoka Hirofumi , Higashino Toshihide , Shimizu Seiko , Ooyama Hiroshi , Morimoto Keito , Uchida Naohiro , Shigesawa Ryuichiro , Takeuchi Kenji , Inoue Ituro , Ichida Kimiyoshi , Suzuki Hiroshi , Shinomiya Nariyoshi , Takada Tappei , Matsuo Hirotaka 
Published: April 2021

Abstract

Objectives
Gout, caused by chronic elevation of serum uric acid levels, is the commonest form of inflammatory arthritis. The causative effect of common and rare variants of ATP-binding cassette transporter G2 (ABCG2/BCRP) on gout risk has been studied, but little attention has been paid to the effect of common (rs121907892, p.W258X) and rare variants of urate transporter 1 (URAT1/SLC22A12) on gout, despite dysfunctional variants of URAT1 having been identified as pathophysiological causes of renal hypouricaemia.

Methods
To address this important but overlooked issue, we investigated the effects of these URAT1 variants on gout susceptibility, using targeted exon sequencing on 480 clinically defined gout cases and 480 controls of Japanese males in combination with a series of functional analyses of newly identified URAT1 variants.

Results
Our results show that both common and rare dysfunctional variants of URAT1 markedly decrease the risk of gout (OR 0.0338, reciprocal OR 29.6, P = 7.66 × 10−8). Interestingly, we also found that the URAT1-related protective effect on gout eclipsed the ABCG2-related causative effect (OR 2.30–3.32). Our findings reveal only one dysfunctional variant of URAT1 to have a substantial anti-gout effect, even in the presence of causative variants of ABCG2, a ‘gout gene’.

Conclusion
Our findings provide a better understanding of gout/hyperuricaemia and its aetiology that is highly relevant to personalized health care. The substantial anti-gout effect of common and rare variants of URAT1 identified in the present study support the genetic concept of a ‘Common Disease, Multiple Common and Rare Variant’ model.
Extended Spaces of Environmental Injustice: Hydrocarbon Pipelines in the Age of Planetary Urbanization
Authors: Braswell Taylor Harris 
Published: April 2021

Abstract
Hydrocarbon pipelines have emerged as a highly contentious political issue in recent years. In this paper, I conduct spatial regression analyses at national and regional scales to determine whether the locations of hydrocarbon pipelines constitute a systemic environmental justice issue throughout the contiguous US transmission pipeline system. National-level analyses show that counties with higher percentages of non-White residents are associated with more kilometers of hydrocarbon pipeline, whereas counties with a higher percentage of residents with a four-year college degree are associated with fewer kilometers of hydrocarbon pipeline. Regional analyses reveal further complexity, showing only degrees of consistency with national-level results. Situating these results within the emergent literature on planetary urbanization, I develop a multiscalar environmental justice framework that I call extended spaces of environmental injustice. Extended spaces of environmental injustice describe the places through which infrastructures of extended urbanization, which are built across vast geographical distances and operate to meet the material needs of urban society, materialize as spatially variegated environmental justice issues at the local scale. I conclude by arguing that the extended spaces of environmental injustice framework can open new pathways for research related to environmental justice and scale, both in analyzing the geography of existing infrastructures of extended urbanization and the construction of future infrastructure as efforts to decarbonize the economy manifest spatially.
Reflection on the Fly: Development of the Team Reflection Behavioral Observation (TuRBO) System for Acute Care Teams
Authors: Schmutz Jan B. , Lei Zhike , Eppich Walter J. 
Published: April 2021

Purpose
Acute care teams work in dynamic and complex environments and must adapt to changing circumstances. A team process that helps teams process information and adapt is in-action team reflection (TR), defined as concurrent collective reflection on group objectives, strategies, or processes during an ongoing care event. However, the health care field lacks a means for systematically observing and ultimately training in-action TR in acute care teams. To bridge this gap, the authors developed a theoretically and empirically informed framework, Team Reflection Behavioral Observation (TuRBO), for measuring in-action TR.

Method
In 2018 at ETH, Zurich, Switzerland, the authors developed a theoretical framework based on the literature and theory. They then conducted exploratory reviews of preexisting videos of acute care teams training simulated emergencies. The authors adapted observation codes using an iterative approach. Using the developed coding framework, they coded 23 video recordings of acute care teams and provided validity evidence from the 3 sources: content, internal structure (interrater reliability), and relations to other variables.

Results
The final TuRBO framework consists of 3 general dimensions—seeking information, evaluating information, and planning—that are further specified in 7 subcodes. Interrater agreement of the coding was substantial (κ = 0.80). As hypothesized, the data showed a positive relationship between in-action TR and team performance. Also, physicians spent significantly more time on in-action TR than nurses.

Conclusions
The TuRBO framework for assessing in-action TR in acute care teams provides positive validity evidence of the data. TuRBO integrates different team communication and calibration processes under the overarching concept of in-action TR and provides descriptive behavioral markers. TuRBO taps into powerful cultural and normative components of patient safety. This tool can augment team training that allows all team members to serve as an important resource for flexible, resilient, and safer patient care.