bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PENGETAHUAN DENGAN SIKAP DALAM PEMBERIAN IMUNISASI DASAR LENGKAP PADA IBU YANG MEMILIKI BAYI 0-9 BULAN DI PUSKESMAS ALIANYANG TAHUN 2016
Authors: Elise Putri Chahyani Erlita, 
Published: August 2021

HUBUNGAN PENGETAHUAN DENGAN SIKAP DALAM PEMBERIAN IMUNISASI DASAR LENGKAP PADA IBU YANG MEMILIKI BAYI 0-9 BULANDI PUSKESMAS ALIANYANG TAHUN 2016Chahyani Erlita1, Elise Putri2Akademi Kebidanan Panca Bhakti PontianakEmail korespondensi: akbidpbpontianak@gmail.comAbstrak
Imunisasi adalah upaya untuk meningkatkan kekebalan tubuh seseorang secara aktif terhadap suatu penyakit. Data yang diperoleh menunjukan bahwa cakupan Universal Child Imunization (UCI) di Kalimantan Barat menduduki posisi ke empat terendah di Indonesia. Data cakupan imunisasi dasar lengkap di Kota Pontianak sebesar 55% dari total target 95%. Tujuan dalam penelitian ini adalah peneliti ingin mengetahui tingkat pengetahuan responden tentang imunisasi dasar lengkap, sikap responden dalam pemberian imunisasi dasar lengkap dan hubungan pengetahuan dan sikap ibu dalam pemberian imunisasi dasar lengkap di Puskesmas Alianyang. Desain penelitian dalam penelitian ini adalah penelitian deskriptif korelasi dengan pendekatan cross sectional. Populasi dari penelitian ini adalah ibu yang memiliki bayi usia 0-9 bulan yaitu sejumlah 306 orang. Sampel dari penelitian ini adalah 31 orang dengan teknik sampel menggunakan teknik accidental. Sumber data menggunakan kuesioner. Berdasarkan hasil penelitian diperoleh hasil sebagian responden memiliki pengetahuan “cukup” dan sikap responden sebagian besar termasuk dalam kategori “mendukung”. Uji chi square menunjukan X2 0,370 dan nilai P value = 1,991 maka Kesimpulkan dari penelitian ini adalah tidak ada hubungan pengetahuan dengan sikap ibu dalam pemberian imunisasi dasar lengkap. Saran untuk tempat penelitian adalah agar dapat melaksanakan kegiatan pendidikan kesehatan secara rutin khususnya mengenai imunisasi dasar lengkap agar dapat meningkatkan pengetahuan tentang imunisasi dasar lengkap sehingga dapat ikut mendukung program pemerintah mengenai imunisasi dasar lengkap yang wajib diberikan pada semua anak.Kata Kunci: Pengetahuan, Sikap, Imunisasi
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PREEKLAMSIA BERAT PADA IBU HAMIL DI RUMAH SAKIT TK II KARTIKA HUSADA KABUPATEN KUBU RAYA TAHUN 2017
Authors: Katarina Iit Chahyani Erlita, 
Published: August 2021

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PREEKLAMSIA BERAT PADA IBU HAMIL DI RUMAH SAKIT TK II KARTIKA HUSADAKABUPATEN KUBU RAYA TAHUN 2017Chahyani Erlita1, Katarina Iit2Akademi Kebidanan Panca Bhakti PontianakEmail korespondensi: akbidpbpontianak@gmail.comAbstrak
Preeklamsia adalah penyakit dengan tanda-tanda hipertensi, proteinuria, dan edema yang timbul karena kehamilan. Penyakit ini terjadi dalam triwulan ke 3 pada kehamilan, tetapi dapat terjadi sebelumnya misalnya pada mola hidatidosa. Berdasarkan data yang didapatkan di Rumah Sakit Bhayangkara Pontianak bulan maret 2015, didapatkan 7 kasus preeklamsia. Tujuan penelitian ini adalah untuk mengetahui hubungan karakteristik yang meliputi usia, paritas, pendidikan, pekerjaan, status ekonomi dengan kejadian preeklamsia. Penelitian menggunakan metode deskriptif korelasi dengan pendekatan retrospektif. Subyek penelitian ini adalah ibu hamil yang mengalami preeklamsia di Rumah Sakit Bhayangkara Pontianak. Penelitian ini menggunakan sampel seluruh populasi yang ada (total populasi) yaitu sebanyak 39 orang ibu. Hasil penelitian menunjukkan bahwa dari 39 kasus ibu dengan preeklamsia banyak terjadi pada kelompok usia 20-35 tahun (76,92%), pada ibu hamil primigravida (82,05%), tingkat pendidikan Atas (74,36%), pada ibu yang tidak bekerja (56,41%), ibu dengan status ekonomi kurang (66,67%), tidak ada hubungan antara karakteristik ibu hamil dengan kejadian preeklamsia. Bagi tempat pelayanan agar dapat meningkatkan kualitas pelayanan dan memberikan pendidikan kesehatan agar mengurangi kasus preeklamsia.Kata Kunci: Karakteristik, Preeklampsia, Ibu Bersalin
LOVE STORIES OF THE MODERN AGE. LARYSA KOSACH, OLHA KOBYLIANSKA: REFLECTIONS
Authors: Romanov Serhii 
Published: August 2021

The paper highlights the key events of the private life of Larysa Kosach and Olha Kobylianska. It focuses on their communication and relations with men (acquaintance, friendship, and love), in particular Serhii Merzhynskyi and Osyp Makovei. The practice of behavior, the emotional and sensual experience of the Ukrainian women from the modern era have been revealed in a comparative aspect. This approach is determined by the special spiritual and sisterly connection between Larysa and Olha, as well as similar stages of experiencing the love feeling. The emphasis is made on the ‘history’ of L. Kosach, which is explained and even duplicated in the ‘history’ of Olha Kobylyanska.
A general shaping of the writers’ personalities has been also considered comparatively. The cultural, psychological, and gender aspects in Ukraine of the late 19th and early 20th centuries had to be taken into account. The typology of both personalities has been traced from the time of their adolescence till their adulthood. The author of the paper pays special attention to the social norms as the oldest way to keep a woman within her nature as it was imagined. The traumatic experience of such social representation and the ways of addressing the issue within literary and autobiographical works are highlighted as well. The problem of expressing oneself is an important psychobiographical factor here. All private and public profiles related to human individuality, female nature, and creative consciousness are worth taking a deeper look at. The break up with the authorities, being a dominant feature for these women, is important for each of the mentioned manifestations of personalities and their integrity. The researcher concludes that biographical material, when properly structured, opens up new perspectives for those focused on the life and creative paths of the famous Ukrainian female writers.
ARTISTIC SYNTHESIS IN CHESS SONNET
Authors: Moisiienko Anatolii 
Published: August 2021

The article focuses on one of the visual types of syncretic poetry — chess poems. Years ago Anatolii Moisiіenko initiated the chess poetry genre in Ukrainian literature; in a number of critical papers, he presented the specifics of construction and functioning of such artistic structures, which are basically characterized by the symbiosis of proper poetry and chess composition. In this article, the author uses Viktor Kapusta’s books of poems “The Checkered Continent” and “Unguaranteed Migrations” to analyze the chess sonnets of the poet who added a new page to the history of Ukrainian visual literary art by proposing a peer-to-peer combination of a strictly structured literary form and a chess problem. The aim is to conceptualize the figurative and compositional relations within the sonnet structure itself, which relies on the artistic palette of the chess game, with its diversity of geometric abstractions, local mise-en-scénes of unpredictable theatrical performances played out on the chess-board by wooden pieces — or on the chessboard of readers’ imagination. Attention is drawn to the transformational peculiarities of the sonnet line, read in a palindromic and pantorhymic way. The pantorhyme is the versificational and compositional basis for the chess sonnet sequence “Castling. A Herbarium of Stars”, which is analyzed here with regard to the transposition of some characteristics to the realm of chess composition. A diagrammed chess problem becomes a specific chess component of a sonnet sequence, where, for example, the variants of the solution (Black’s defensive moves and White’s attacking responses) correspond to the poetic lines making up the fourteen sonnets whereas the problem’s threat, like a principal poem, concentrates all the mentioned chess movements in a single variant.
Pengaruh Indeks Massa Tubuh Terhadap Keseimbangan Postural Dinamis Pada Mahasiswa Universitas Esa Unggul
Authors: Amir Trisia Lusiana , Azi Yohanes Paulus Meo 
Published: August 2021

Dynamic postural balance is very beneficial for the smooth running of daily activities and reduces the risk of falling. One of the factors that affect the body's postural balance is Body Mass Index (BMI). The purpose of this study was to determine the effect of BMI to dynamic postural balance in Esa Unggul University (UEU) students. This research is a descriptive analytic study with a cross-sectional design. The total sample in this study was 46 UEU students taken by simple random sampling. BMI is calculated as weight in kilograms divided by the square of the height in meters (kg/m2) and is categorized into three groups: underweight (<18.5 kg/m2), normal (18.5-22.99 kg/m2 ), overweight and obesity (>23 kg/m2). Dynamic postural balance data was measured by Y-BT (Y-Balance Test). Hypothesis testing with one-way Anova test at =0.05 showed a significant p=0,001. So, the result of statistical analyses revealed that there seemed to be a tight effect between BMI and dynamic postural balance in students (p=0.001), especially on UEU students.
Development of Personas to Communicate Narrative-Based Information About the HPV Vaccine on Twitter
Authors: Massey Philip M. , Chiang Shawn C. , Rose Meredith , Murray Regan M. , Rockett Madeline , Togo Elikem , Klassen Ann C. , Manganello Jennifer A. , Leader Amy E. 
Published: August 2021

Introduction: Personas are based on real-life typologies of people that can be used to create characters and messages to communicate important health information through relatable narrative storylines. Persona development is data-driven and can involve multiple phases of formative research and evaluation; however, personas are largely underutilized in digital health research. The purpose of this study was to create and document persona development to deliver narrative-focused health education for parents on Twitter with the goal of increasing uptake of HPV vaccination among adolescents.Methods: Leveraging data from a mixed-method study conducted in the U.S. with a diverse population of parents with adolescents ages 9–14, we used both qualitative and quantitative data (e.g., the National Immunization Survey—Teen, focus groups, and social media) to create personas. These data sources were used to identify and develop key characteristics for personas to reflect a range of parents and their diverse understandings and experiences related to HPV vaccination. A parent advisory board provided insight and helped refine persona development.Results: Four personas emerged and were characterized as the (1) Informed Altruist, (2) Real Talker, (3) Information Gatherer, and (4) Supporter. Characteristics differed across personas and provided insights into targeted narrative strategies. Described attributes included demographics, psychographics, communication style, vaccine goals and aspirations, vaccine challenges and frustrations, and vaccine hesitancy.Discussion: This work demonstrates how multiple data sources can be used to create personas to deliver social media messages that can address the diverse preferences and needs of parents for HPV vaccine information. With increasing usage of social media for health information among parents, it is important for researchers to consider marketing and design thinking to create health communication messages that resonate with audiences.
Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study
Authors: Cossu Davide , Yokoyama Kazumasa , Sechi Leonardo Antonio , Hattori Nobutaka 
Published: August 2021

BackgroundMitochondrial dysfunction has been suggested to play an important role in all stages of multiple sclerosis (MS).ObjectiveTo determine the expression of two mitophagy-related proteins, PTEN-induced kinase 1 (PINK1) and PARKIN, in a cohort of Japanese patients with different neuroinflammatory disorders.MethodsProtein concentrations were measured using commercial ELISA in paired cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody disorders (MOGAD), and from age- and sex-matched controls.ResultsCSF and serum concentrations of PINK1 were higher in patients with MS than in patients with NMOSD (p = 0.004 and p &lt; 0.001, respectively), MOGAD (p = 0.008 and p = 0.011, respectively), and controls (p = 0.021 and p = 0.002, respectively). CSF and concentrations of PARKIN were elevated in patients with MS in comparison with those in controls (p = 0.016 and p = 0.05, respectively).ConclusionsOur study highlighted the importance of mitophagy in MS and suggested the potential application of PINK1 and PARKIN as biomarkers to predict disease activity.
Therapeutic Response and Possible Biomarkers in Acute Attacks of Neuromyelitis Optica Spectrum Disorders: A Prospective Observational Study
Authors: Wang Jingqi , Cui Chunping , Lu Yaxin , Chang Yanyu , Wang Yuge , Li Rui , Shan Yilong , Sun Xiaobo , Long Youming , Wang Honghao , Wang Zhanhang , Lee Michael , He Shane , Lu Zhengqi , Qiu Wei , Tan Sha 
Published: August 2021

ObjectiveTo explore the outcomes of NMOSD attacks and investigate serum biomarkers for prognosis and severity.MethodPatients with NMOSD attacks were prospectively and observationally enrolled from January 2019 to December 2020 at four hospitals in Guangzhou, southern China. Data were collected at attack, discharge and 1/3/6 months after acute treatment. Serum cytokine/chemokine and neurofilament light chain (NfL) levels were examined at the onset stage.ResultsOne hundred patients with NMOSD attacks were included. The treatment comprised intravenous methylprednisolone pulse therapy alone (IVMP, 71%), IVMP combined with apheresis (8%), IVMP combined with intravenous immunoglobulin (18%) and other therapies (3%). EDSS scores decreased significantly from a medium of 4 (interquartile range 3.0–5.5) at attack to 3.5 (3.0–4.5) at discharge, 3.5 (2.0–4.0) at the 1-month visit and 3.0 (2.0–4.0) at the 3-month visit (p&lt;0.01 in all comparisons). The remission rate was 38.0% at discharge and 63.3% at the 1-month visit. Notably, relapse occurred in 12.2% of 74 patients by the 6-month follow-up. Higher levels of T helper cell 2 (Th2)-related cytokines, including interleukin (IL)-4, IL-10, IL-13, and IL-1 receptor antagonist, predicted remission at the 1-month visit (OR=9.33, p=0.04). Serum NfL levels correlated positively with onset EDSS scores in acute-phase NMOSD (p&lt;0.001, R2 = 0.487).ConclusionsOutcomes of NMOSD attacks were generally moderate. A high level of serum Th2-related cytokines predicted remission at the 1-month visit, and serum NfL may serve as a biomarker of disease severity at attack.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT04101058, identifier NCT04101058.
Identification of Candidate Biomarkers and Prognostic Analysis in Colorectal Cancer Liver Metastases
Authors: Zhang Tianhao , Yuan Kaitao , Wang Yingzhao , Xu Mingze , Cai Shirong , Chen Chuangqi , Ma Jinping 
Published: August 2021

BackgroundColorectal cancer (CRC), one of the most common malignant tumors worldwide, has a high mortality rate, especially for patients with CRC liver metastasis (CLM). However, CLM pathogenesis remains unclear.MethodsWe integrated multiple cohort datasets and databases to clarify and verify potential key candidate biomarkers and signal transduction pathways in CLM. GEO2R, DAVID 6.8, ImageGP, STRING, UALCAN, ONCOMINE, THE HUMAN PROTEIN ATLAS, GEPIA 2.0, cBioPortal, TIMER 2.0, DRUGSURV, CRN, GSEA 4.0.3, FUNRICH 3.1.3 and R 4.0.3 were utilized in this study.ResultsSixty-three pairs of matched colorectal primary cancer and liver metastatic gene expression profiles were screened from three gene expression profiles (GSE6988, GSE14297 and GSE81558). Thirty-one up-regulated genes and four down-regulated genes were identified from these three gene expression profiles and verified by another gene expression profiles (GSE 49355) and TCGA database. Two pathways (IGFBP-IGF signaling pathway and complement-coagulation cascade), eighteen key differentially expressed genes (DEGs), six hub genes (SPARCL1, CDH2, CP, HP, TF and SERPINA5) and two biomarkers (CDH2 and SPARCL1) with significantly prognostic values were screened by multi-omics data analysis and verified by Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) cohort.ConclusionsIn this study, we identified a robust set of potential candidate biomarkers in CLM, which would provide potential value for early diagnosis and prognosis, and would promote molecular targeting therapy for CRC and CLM.
Arterial Load and Norepinephrine Are Associated With the Response of the Cardiovascular System to Fluid Expansion
Authors: Nguyen Maxime , Mallat Jihad , Marc Julien , Abou-Arab Osama , Bouhemad Bélaïd , Guinot Pierre-Grégoire 
Published: August 2021

BackgroundFluid responsiveness has been extensively studied by using the preload prism. The arterial load might be a factor modulating the fluid responsiveness. The norepinephrine (NE) administration increases the arterial load and modifies the vascular properties. The objective of the present study was to determine the relationship between fluid responsiveness, preload, arterial load, and NE use. We hypothesized that as a preload/arterial load, NE use may affect fluid responsiveness.MethodsThe retrospective multicentered analysis of the pooled data from 446 patients monitored using the transpulmonary thermodilution before and after fluid expansion (FE) was performed. FE was standardized between intensive care units (ICUs). The comparison of patients with and without NE at the time of fluid infusion was performed. Stroke volume (SV) responsiveness was defined as an increase of more than 15% of SV following the FE. Pressure responsiveness was defined as an increase of more than 15% of mean arterial pressure (MAP) following the FE. Arterial elastance was used as a surrogate for the arterial load.ResultsA total of 244 patients were treated with NE and 202 were not treated with NE. By using the univariate analysis, arterial elastance was correlated to SV variations with FE. However, the SV variations were not associated with NE administration (26 [15; 46]% vs. 23 [10; 37]%, p = 0.12). By using the multivariate analysis, high arterial load and NE administration were associated with fluid responsiveness. The association between arterial elastance and fluid responsiveness was less important in patients treated with NE. Arterial compliance increased in the absence of NE, but it did not change in patients treated with NE (6 [−8; 19]% vs. 0 [−13; 15]%, p = 0.03). The changes in total peripheral and arterial elastance were less important in patients treated with NE (−8 [−17; 1]% vs. −11 [−20; 0]%, p &lt; 0.05 and −10 [−19; 0]% vs. −16 [−24; 0]%, p = 0.01).ConclusionThe arterial load and NE administration were associated with fluid responsiveness. A high arterial load was associated with fluid responsiveness. In patients treated with NE, this association was lower, and the changes of arterial load following FE seemed to be driven mainly by its resistive component.
Effects of Experiential Learning Programmes on Adolescent Prosocial Behaviour, Empathy, and Subjective Well-being: A Systematic Review and Meta-Analysis
Authors: Chan Hannah Hoi-Kiu , Kwong Ho Yee Chloe , Shu Geisty Lin Feng , Ting Chung Yan , Lai Frank Ho-Yin 
Published: August 2021

Introduction:Effective adolescent learning programmes can positively influence adolescent development and curb risky behaviour. By immersing learners in an experience, experiential learning motivates learners to reflect on the experience to transform and create new skills, attitudes and ways of thinking. However, evidence of its effectiveness in learning programs facilitating positive youth development is still lacking. The objective of this study is to (a) identify the effect of adolescent learning programmes on prosocial behaviour, empathy and subjective well-being, (b) compare the effectiveness of experiential learning programmes and non-experiential learning programmes on improving these three outcomes, and (c) evaluating the effects of age on the outcomes of adolescent learning programmes.Methods:This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomised controlled trials of learning programmes for typically developing adolescents aged 8–25 in the past 15 years were identified, and assessed for quality with the Physiotherapy Evidence Database (PEDRO) scale. One thousand ninety-six records were screened with the inclusion and exclusion criteria, and 20 studies were adopted for this meta-analysis. The standardised mean difference and 95% confidence interval (CI) of the effect of experiential learning program on empathy, prosocial behaviour, and subjective well-being were examined. Sub-group analysis based on age was conducted to examine the effects of experiential learning on adolescents in different stages of life.Results:Experiential learning programmes were more effective than non-experiential learning programmes in improving empathy [d = 0.65 (0.07, 1.23)] and subjective well-being [d = 0.46 (0.33, 0.59)]. The effect sizes of the three outcomes in non-experiential learning programmes were non-significant. Studies conducted on older adolescents had the most significant improvements in the three outcomes.Conclusions:Results suggest the broader application of experiential learning in adolescent learning programmes for older adolescents in the future to promote positive youth development.
Household Air Pollution From Solid Cooking Fuel Combustion and Female Breast Cancer
Authors: Liu Tanxin , Chen Ru , Zheng Rongshou , Li Liming , Wang Shengfeng 
Published: August 2021

Background: Women bear a large share of disease burden caused by household air pollution due to their great involvement in domestic activities. Pollutant emissions are believed to vary by exposure patterns such as cooking and space heating. Little is known about the independent effect of solid cooking fuel combustion on breast cancer risk. We aimed to examine the association of indoor coal and wood combustion for cooking with breast cancer risk.Methods: During June 2004–July 2008, participants aged 30–79 from 10 diverse regions across China were enrolled in the China Kadoorie Biobank. Primary cooking fuel use information in up to three residences was self-reported at baseline. Multivariable logistic regression models yielded adjusted odds ratios (ORs) and 95% confidence intervals (CIs).Results: A total of 290,396 female participants aged 30–79 were included in the main analysis. Compared with long-term clean fuel users, the fully adjusted ORs were 2.07 (95%CI: 1.37–3.13) for long-term coal users, 1.12 (95% CI: 0.72–1.76) for long-term wood users, and 0.98 (95% CI: 0.55–1.74) for those who used mixed solid fuels to cook. Those who had switched from solid to clean fuels did not have an excess risk of breast cancer (OR: 0.88, 95%CI 0.71–1.10).Conclusion: Long-term solid fuel combustion for cooking may increase the risk of breast cancer. The strength of association is stronger among coal users than wood users. Targeted interventions are needed to accelerate the access to clean and affordable energy.