bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS RELAKSASI PERNAFASAN TERHADAP KECEMASAN PADA IBU HAMIL TRIMESTER III
Authors: Syahida Ayunin , Mirani Nanda 
Published: November 2021

Background: During pregnancy, mothers experience physical and psychological changes that occur due to hormonal changes.The process of adjusting to new conditions experienced by pregnant women can then cause anxiety. To overcome anxiety during pregnancy, non-pharmacological options. Interventions that are often used and proven effective to reduce anxiety are breathing relaxation techniques.Purpose: This study aims to determine the analysis Breathing Relaxation on Anxiety in Pregnant Women in Trimester III in the Work in Puskesmas Langsa Baro.Methods: The designs used in this study were quasi-experimental designs with a one-group pre-test and post-test design approach. The number of research samples was 15 third trimester pregnant women, the sampling technique used was purposive sampling technique. Data analysis was carried out univariate and bivariate using the Paired T-Test.Results: The results showed that the level of anxiety was known to have a p value (sig) (0.000) < 0.05, which means that there is an effect of breathing relaxation on anxiety in trimester III pregnant women.Conclusion: There is an effect of breathing relaxation on anxiety in trimester III pregnant women. It is hoped that health workers will increase counseling about pregnancy, especially about problems that can occur during pregnancy so that mothers can be more relaxed in dealing with pregnancy and childbirth. Keywords: Breathing Relaxation, Anxiety, Pregnant ABSTRAKLatar Belakang: Selama kehamilan ibu mengalami perubahan fisik dan psikis yang terjadi akibat perubahan hormon. Proses penyesuaian diri terhadap keadaan baru yang dialami ibu hamil ini kemudian dapat menimbulkan kecemasan. Untuk mengatasi kecemasan pada saat hamil, pilihan non farmakologis. Intervensi yang sering di gunakan dan terbukti efektif untuk mengurangi kecemasan adalah teknik relaksasi pernafasan dan dzikir.Tujuan: Penelitian ini bertujuan untuk menganalisis Relaksasi Pernafasan Terhadap Kecemasan Pada Ibu Hamil Trimester III di Wilayah Kerja Puskesmas Langsa Baro Tahun 2021.Metode: Desain yang digunakan dalam penelitian ini adalah quasi eksperiment designs (eksperimen semu) dengan pendekatan one group pre test and post test design. Jumlah sampel penelitian sebanyak 15 ibu hamil trimester III. Teknik sampling yang digunakan teknik purposive sampling. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Paired T-Test.Hasil:Hasil penelitian didapatkan bahwa tingkat kecemasan diketahui nilai p (sig) (0,000) < 0,05 yang artinya terdapat pengaruh relaksasi pernafasan terhadap kecemasan pada ibu hamil trimester III. Kesimpulan: Ada pengaruh kombinasi relaksasi pernafasan dan dzikir terhadap kecemasan pada ibu hamil trimester III. Diharapkan agar tenaga kesehatan lebih meningkatkan penyuluhan tentang kehamilan terutama tentang masalah-masalah yang dapat terjadi pada masa kehamilan sehingga ibu dapat lebih santai dalam menghadapi masa kehamilan dan persalinan. Kata Kunci: Relaksasi Pernafasan, Kecemasan, Kehamilan
An osteopathic approach to occipital neuralgia and tinnitus
Authors: Aiman Alexis , Skaug Joy , Fleming Regina 
Published: November 2021

Eye pain and ringing in the ear are non-specific symptoms commonly evaluated by primary care physicians and specialists alike. The differential diagnosis for these symptoms is broad and includes musculoskeletal, ophthalmologic and neurologic considerations. Careful consideration of the differential diagnosis should include acute, potentially life-threatening pathologies such as glaucoma or intracranial masses, as well as common pathologies, including cervicalgia, headache variants (migraine, tension) and acoustic neuroma.
This report describes a patient with eye pain caused by occipital neuralgia and tinnitus. Correcting the somatic dysfunctions found in the head, cervical, thoracic and rib regions with osteopathic manipulative treatment resolved the occipital neuralgia and the tinnitus for this patient. Thus, osteopathic manipulative treatment should be considered for conservative management of occipital neuralgia and tinnitus.
Improving diagnosis and treatment of benign paroxysmal positional vertigo
Authors: McIntire Larry , Martin Kindall , Motzkus Gregory , Shah Kunal , Malinowski Lauren , Paulson John 
Published: November 2021

Background: Vertigo is defined as an illusion of motion caused by a mismatch of information between the visual, vestibular and somatosensory systems. The most common diagnosis associated with whirling vertigo is benign paroxysmal positional vertigo (BPPV), which affects approximately 3.4% of patients older than 60 years of age.
Objective: This paper aims to educate primary care providers on how to diagnose BPPV by performing canalith repositioning maneuvers at the initial point of care. Timely treatment of BPPV in the primary care office is believed to reduce healthcare costs by way of limiting unnecessary diagnostic testing and lowering referrals for specialty care. Immediate treatment is also believed to improve the quality of healthcare delivery for the vertigo patient by reducing morbidity and resolving the condition without the need for referrals or imaging.
Population Health: A review of the literature finds that delayed diagnosis and treatment of BPPV is associated with a host of deleterious effects on patients. Population health impacts include increasedrates of anxiety and depression; loss of work and/or change of career paths; inappropriate use of medications or emergency care resources; decreased access to healthcare services; increased healthcare costs; and reduced quality of care.
Diagnosis: A history of positional vertigo and evidence of nystagmus with Dix-Hallpike positioning confirms the diagnosis. A detailed description of the performance of this test is elucidated.
Treatment: The observed nystagmus is analyzed and classified based on directionality. Treatment can be initiated immediately with canalith repositioning maneuvers.
Alterações no paladar advindos de quimioterapia convencional
Authors: Silva Eduardo Henrique dos Santos , Aguiar Yuri Lopes de , Amaral Polyana Argolo Souza , Pereira Lara Correia 
Published: November 2021

O câncer está ligado ao aumento desordenado de células, possui a capacidade de invadir tecidos vizinhos no local de origem e/ou instalar-se em órgãos distantes via corrente sanguínea. O tratamento antineoplásico pode gerar efeitos colaterais, na mucosa oral, ficando evidente através do surgimento da mucosite oral. Também podemos observar alterações no paladar, como: hipogeusia, disgeusia, ageusia e hipergeusia. O presente trabalho visa revisar a literatura acerca das alterações do paladar provocadas por 5-fluoruracila (5-FU), leucovorine, oxaliplatina, gencitabine, capecitabine, cisplatina, ciclofosfamida, doxorubicina, irinotecan e metotrexato, sendo medicamentos antineoplásicos convencionais. Este estudo foi realizado através do levantamento de dados no período de 2009 até 2021, a partir da literatura científica na base de dados PubMed, Lilacs, Cochrane e Scielo em língua inglesa e espanhola, valendo-se das palavras chaves Antinéoplasicos; Paladar Distorcido; Disgeusia; Estomatite; Cavidade Oral; juntamente com os operadorer booleanos “and” e “or”, de forma a combinar os descritores citados. Diante do exposto, os fármacos quimioterápicos convencionais afetam as células gustativas e os processos bioquímicos referentes a sua renovação celular, gerando alterações no paladar como hipogeusia, disgeusia, ageusia e hipergeusia.
Respostas fisiológicas da cana-de-açúcar com suplementação potássica em dois regimes hídricos
Authors: Ribeiro Pedro Henrique , Gava Glauber José de Castro , Arlanch Adolfo Bergamo , Teixeira Marconi Batista , Santos Evaldo Alves dos , Cabral Filho Fernando Rodrigues , Lelis Neto João Alberto , Cunha Fernando Nobre , Alves Daniely Karen Matias , Bastos Alefe Viana Souza , Silva Edson Cabral da , Vidal Vitor Marques , Morais Wilker Alves 
Published: November 2021

A cana-de-açúcar é uma das principais culturas exploradas no Brasil, seja em condições de sequeiro ou irrigada. A água e o nutriente potássio são insumos que podem interferir na fisiologia dessa cultura e, quando fornecido em fertirrigação, permite uma maior eficiência do uso da água e de fertilizantes. O potássio é o nutriente mais exigido pela cana-de-açúcar e a sua eficiência é melhorada quando se utiliza a fertirrigação. Assim, objetivou-se avaliar as respostas fisiológicas da cana-de-açúcar durante o terceiro ciclo de cultivo (soqueira) quanto à aplicação de doses de potássio em condições de sequeiro e irrigação. O experimento foi desenvolvido em esquema de parcelas subdivididas (4 x 2), sendo quatro doses de adubação potássica (0, 70, 140 e 210 kg ha-1 de K2O) com e sem irrigação. A condutância estomática foi maior quando as plantas de cana-de-açúcar foram irrigadas em todas as doses de potássio estudadas, exceto para o controle aos 235 e 393 dias após o corte. O índice SPAD não apresentou diferença entre as condições irrigado e sequeiro em todas as doses de adubação potássica e épocas de avaliação. Há diferença no índice de área foliar entre as plantas irrigadas e em condições de sequeiro apenas quando se aplica a dose de 140 kg ha-1 de K2O aos 340 dias após o corte.
In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
Authors: Kling Sabine 
Published: November 2021

A novel approach is presented for the non-invasive quantification of axial displacement and strain in corneal and anterior crystalline lens tissue in response to a homogenous ambient pressure change. A spectral domain optical coherence tomography (OCT) system was combined with a custom-built set of swimming goggles and a pressure control unit to acquire repetitive cross-sectional scans of the anterior ocular segment before, during and after ambient pressure modulation. The potential of the technique is demonstrated in vivo in a healthy human subject. The quantification of the dynamic deformation response, consisting of axial displacement and strain, demonstrated an initial retraction of the eye globe (−0.43 to −1.22 nm) and a subsequent forward motion (1.99 nm) in response to the pressure change, which went along with a compressive strain induced in the anterior crystalline lens (−0.009) and a tensile strain induced in the cornea (0.014). These mechanical responses appear to be the result of a combination of whole eye motion and eye globe expansion. The latter simulates a close-to-physiologic variation of the intraocular pressure and makes the detected mechanical responses potentially relevant for clinical follow-up and pre-surgical screening. The presented measurements are a proof-of-concept that non-contact low-amplitude ambient pressure modulation induces tissue displacement and strain that is detectable in vivo with OCT. To take full advantage of the high spatial resolution this imaging technique could offer, further software and hardware optimization will be necessary to overcome the current limitation of involuntary eye motions.
The m6A RNA Modification Modulates Gene Expression and Fibrosis-Related Pathways in Hypertrophic Scar
Authors: Liu Si-Yu , Wu Jun-Jie , Chen Zhong-hua , Zou Ming-Li , Teng Ying-ying , Zhang Kai-Wen , Li Yue-Yue , Guo Dang-yang , Yuan Feng-Lai 
Published: November 2021

Purpose: To systematically analyze the overall m6A modification pattern in hyperplastic scars (HS).Methods: The m6A modification patterns in HS and normal skin (NS) tissues were described by m6A sequencing and RNA sequencing, and subsequently bioinformatics analysis was performed. The m6A-related RNA was immunoprecipitated and verified by real-time quantitative PCR.Results: The appearance of 14,791 new m6A peaks in the HS sample was accompanied by the disappearance of 7,835 peaks. The unique m6A-related genes in HS were thus associated with fibrosis-related pathways. We identified the differentially expressed mRNA transcripts in HS samples with hyper-methylated or hypo-methylated m6A peaks.Conclusion: This study is the first to map the m6A transcriptome of human HS, which may help clarify the possible mechanism of m6A-mediated gene expression regulation.
A Ferroptosis and Pyroptosis Molecular Subtype-Related Signature Applicable for Prognosis and Immune Microenvironment Estimation in Hepatocellular Carcinoma
Authors: Huo Junyu , Cai Jinzhen , Guan Ge , Liu Huan , Wu Liqun 
Published: November 2021

Background:Due to the heterogeneity of tumors and the complexity of the immune microenvironment, the specific role of ferroptosis and pyroptosis in hepatocellular carcinoma (HCC) is not fully understood, especially its impact on prognosis.Methods:The training set (n= 609, merged by TCGA and GSE14520) was clustered into three subtypes (C1, C2, and C3) based on the prognosis-related genes associated with ferroptosis and pyroptosis. The intersecting differentially expressed genes (DEGs) among C1, C2, and C3 were used in univariate Cox and LASSO penalized Cox regression analysis for the construction of the risk score. The median risk score served as the unified cutoff to divide patients into high- and low-risk groups.Results:Internal (TCGA,n= 370; GSE14520,n= 239) and external validation (ICGC,n= 231) suggested that the 12-gene risk score had high accuracy in predicting the OS, DSS, DFS, PFS, and RFS of HCC. As an independent prognostic indicator, the risk score could be applicable for patients with different clinical features tested by subgroup (n= 26) survival analysis. In the high-risk patients with a lower infiltration abundance of activated B cells, activated CD8 T cells, eosinophils, and type I T helper cells and a higher infiltration abundance of immature dendritic cells, the cytolytic activity, HLA, inflammation promotion, and type I IFN response in the high-risk group were weaker. The TP53 mutation rate, TMB, and CSC characteristics in the high-risk group were significantly higher than those in the low-risk group. Low-risk patients have active metabolic activity and a more robust immune response. The high- and low-risk groups differed significantly in histology grade, vascular tumor cell type, AFP, new tumor event after initial treatment, main tumor size, cirrhosis, TNM stage, BCLC stage, and CLIP score.Conclusion:The ferroptosis and pyroptosis molecular subtype-related signature identified and validated in this work is applicable for prognosis prediction, immune microenvironment estimation, stem cell characteristics, and clinical feature assessment in HCC.
Near-Infrared-II Bioimaging for in Vivo Quantitative Analysis
Authors: Yang Sha , Tan Xiaofeng , Tang Li , Yang Qinglai 
Published: November 2021

Near-Infrared-II (NIR-II) bioimaging is a newly emerging visualization modality in real-time investigations of biological processes research. Owning to advances in reducing photon scattering and low tissue autofluorescence levels in NIR-II region (1,000–1700 nm), NIR-II bioimaging affords high resolution with increasing tissue penetration depth, and it shows greater application potential for in vivo detection to obtain more detailed qualitative and quantitative parameters. Herein, this review summarizes recent progresses made on NIR-II bioimaging for quantitative analysis. These emergences of various NIR-II fluorescence, photoacoustic (PA), luminescence lifetime imaging probes and their quantitative analysis applications are comprehensively discussed, and perspectives on potential challenges facing in this direction are also raised.
Comparison of the Association Between Arterial Stiffness Indices and Heart Failure in Patients With High Cardiovascular Risk: A Retrospective Study
Authors: Lee Chan Joo , Yoon Minjae , Ha Jaehyung , Oh Jaewon , Park Sungha , Lee Sang-Hak , Kang Seok-Min 
Published: November 2021

Objective: Study findings of the relationship of each arterial stiffness index with incident heart failure (HF) are conflicting. We aimed to compare the association between the indices of arterial stiffness and the risk of HF.Methods: We analysed 3,034 patients from a prospective cohort that enrolled patients with high cardiovascular risk. They underwent brachial-ankle pulse wave velocity (baPWV), brachial pulse pressure (PP), carotid-femoral pulse wave velocity (cfPWV), and central PP measurements.Results: Over a median follow-up of 4.7 years (interquartile range, 3.4–5.8 years), 65 HF events occurred. The incidence rate of HF was 4.7 per 1,000 person-years [95% confidence interval (CI), 3.7–6.0]. There was no difference in baPWV in those with and without HF events (1,561 ± 401 and 1,520 ± 321 cm/s, respectively, P = 0.415); however, there was a significant difference in brachial PP (63.2 ± 16.9 vs. 52.3 ± 11.5 mmHg, P &lt; 0.001), cfPWV (11.0 ± 3.1 vs. 9.4 ± 2.4 m/s, P &lt; 0.001) and central PP (56.6 ± 19.9 vs. 42.9 ± 13.8 mmHg, P &lt; 0.001). In the multivariable-adjusted model, brachial PP [hazards ratio (HR) per standard deviation unit (SDU), 1.48; 95% CI, 1.19–1.84, P &lt; 0.001], cfPWV (HR per SDU, 1.29; 95% CI, 1.02–1.63, P = 0.032) and central PP (HR per SDU, 1.44; 95% CI, 1.17–1.78; P &lt; 0.001) were associated with incident HF, but baPWV was not (HR per SDU, 0.83; 95% CI, 0.63–1.10; P = 0.198). In the receiver operating characteristic analysis, the area under the curve (AUC) of brachial PP (P &lt; 0.001), cfPWV (P = 0.003) or central PP (P = 0.001) was larger than that of baPWV, and there was no difference in the AUCs of brachial PP, cfPWV and central PP.Conclusion: Among arterial stiffness indices, brachial PWV was less associated with the risk of heart failure, and brachial PP and measures representing central hemodynamics were highly associated with incident HF.
Identification of Immune-Related Key Genes in Ovarian Cancer Based on WGCNA
Authors: Quan Qingli , Xiong Xinxin , Wu Shanyun , Yu Meixing 
Published: November 2021

Background: Ovarian cancer (OV) is a fatal gynecologic malignancy and has poor survival rate in women over the age of forty. In our study, we aimed to identify genes related to immune microenvironment regulations and explore genes associated with OV prognosis.Methods: The RNA-seq data of GDC TCGA Ovarian Cancer cohort of 376 patients was retrieved from website. Weighted gene co-expression network analysis (WGCNA) and ESTIMATE algorithm were applied to identify the key genes associated with the immune scores. The correlation between key genes and 22 immune cell types were estimated by using CIBERSORT algorithms.Results: WGCNA showed that the pink module was most correlated with the immune score. Seven of 14 key genes (FCRL3, IFNG, KCNA3, LY9, PLA2G2D, THEMIS, and TRAT1) were significantly associated with the OS of OV patients. Correlation analysis showed our key genes positively related to M1 macrophages, CD8 T cells, plasma cells, regulatory T (Treg) cells and activated memory CD4 T cells, and negatively related to naive CD4 T cells, M0 macrophages, activated dendritic cells (DCs) and memory B cells. Kaplan-Meier survival analysis showed that lower abundances of neutrophils and higher abundances of M1 macrophages, plasma cells, T cells gamma delta (γδT) cells and follicular helper T (Tfh) cells predicted better OV prognosis.Conclusion: Forteen key genes related to the immune infiltrating of OV were identified, and seven of them were significantly related to prognosis. These key genes have potential roles in tumor infiltrating immune cells differentiation and proliferation. This study provided potential prognostic markers and immunotherapy targets for OV.
Experimental Investigation on Strength and Failure Characteristics of Cemented Paste Backfill
Authors: Zhang Zhihong , Li Jiacheng 
Published: November 2021

The strength characteristics of cemented paste backfill (CPB) in mining areas are key control factors for the safety assessment of overlying strata. A series of experiments about uniaxial compression and triaxial compression were carried out to study the influence of cement content of filling slurry, curing age, and curing temperature on strength behavior of CPB specimens. The failure mechanism and damage feature of CPB have been investigated. The results show the following: (1) The uniaxial compressive strength of CPB specimens exhibits an upward trend with the increase of cement content and curing age. When the cement content is high, the uniaxial compressive strength increases sharply with increasing curing age. (2) The cohesion of CPB specimens increases with the increase of cement content of filling slurry, curing age, and curing temperature. The cohesion of CPB specimens with curing age 7 days and 14 days increases linearly with increasing cement content. At the later stage of curing age, the strength growth of high cement content backfill is significantly greater than that of low cement content. The internal friction angle of the filling increases slightly with increasing filling cement content, curing age, and curing temperature. (3) The shear strength of CPB specimens at curing age 7 days exhibits an upward trend with the increase of confining pressure, while the shear strength at 14 days and 28 days curing age decreases slightly as the confining pressure increases. (4) With the increase of cement content in backfill, the brittleness increases significantly when the backfill is damaged. The failure mode of CPB specimens changes from monoclinic section shear failure to X-type failure with increasing curing age, and the failure process is divided into four stages: pore compaction, linear elastic deformation, plastic deformation, and post-peak failure.
Incidence and Mortality of Acute Respiratory Distress Syndrome in Patients With Burns: A Systematic Review and Meta-Analysis
Authors: Wang Baoli , Chenru Wei , Jiang Yong , Hu Lunyang , Fang He , Zhu Feng , Yu Qing , Zhu Banghui , Wu Guosheng , Sun Yu , Xia Zhaofan 
Published: November 2021

Objective: We conducted a systematic review and meta-analysis to comprehensively estimate the incidence and mortality of acute respiratory distress syndrome (ARDS) in overall and subgroups of patients with burns.Data sources: Pubmed, Embase, the Cochrane Library, CINAHL databases, and China National Knowledge Infrastructure database were searched until September 1, 2021.Study selection: Articles that report study data on incidence or mortality of ARDS in patients with burns were selected.Data extraction: Two researchers independently screened the literature, extracted data, and assessed the quality. We performed a meta-analysis of the incidence and mortality of ARDS in patients with burns using a random effects model, which made subgroup analysis according to the study type, inclusion (mechanical ventilation, minimal burn surface), definitions of ARDS, geographic location, mean age, burn severity, and inhalation injury. Primary outcomes were the incidence and mortality of burns patients with ARDS, and secondary outcomes were incidence for different subgroups.Data synthesis: Pooled weighted estimate of the incidence and mortality of ARDS in patients with burns was 0.24 [95% confidence interval (CI)0.2–0.28] and 0.31 [95% CI 0.18−0.44]. Incidences of ARDS were obviously higher in patients on mechanical ventilation (incidence = 0.37), diagnosed by Berlin definition (incidence = 0.35), and with over 50% inhalation injury proportion (incidence = 0.41) than in overall patients with burns. Patients with burns who came from western countries and with inhalation injury have a significantly higher incidence of ARDS compared with those who came from Asian/African countries (0.28 vs. 0.25) and without inhalation injury (0.41 vs. 0.24).Conclusion: This systematic review and meta-analysis revealed that the incidence of ARDS in patients with burns is 24% and that mortality is as high as 31%. The incidence rates are related to mechanical ventilation, location, and inhalation injury. The patients with burns from western countries and with inhalation injury have a significantly higher incidence than patients from Asian/African countries and without inhalation injury.Systematic Review Registration: identifier: CRD42021144888.