bluuebunny/crossref_metadata_2025_split huggingface dataset:
New method to measure interbreath intervals in infants for the assessment of apnoea and respiration
Authors: Adjei Tricia , Purdy Ryan , Jorge João , Adams Eleri , Buckle Miranda , Evans Fry Ria , Green Gabrielle , Patel Chetan , Rogers Richard , Slater Rebeccah , Tarassenko Lionel , Villarroel Mauricio , Hartley Caroline 
Published: December 2021

BackgroundRespiratory disorders, including apnoea, are common in preterm infants due to their immature respiratory control compared with term-born infants. However, our inability to accurately measure respiratory rate in hospitalised infants results in unreported episodes of apnoea and an incomplete picture of respiratory activity.MethodsWe develop, validate and use a novel algorithm to identify interbreath intervals (IBIs) and apnoeas in preterm infants. In 42 preterm infants (1600 hours of recordings), we assess IBIs from the chest electrical impedance pneumograph using an adaptive amplitude threshold for the detection of breaths. The algorithm is refined by comparing its accuracy with clinically observed breaths and pauses in breathing. We develop an automated classifier to differentiate periods of true apnoea from artefactually low amplitude signal. We assess the performance of this algorithm in the detection of morphine-induced respiratory depression. Finally, we use the algorithm to investigate whether retinopathy of prematurity (ROP) screening alters the IBI distribution.ResultsIndividual breaths were detected with a false-positive rate of 13% and a false-negative rate of 12%. The classifier identified true apnoeas with an accuracy of 93%. As expected, morphine caused a significant shift in the IBI distribution towards longer IBIs. Following ROP screening, there was a significant increase in pauses in breathing that lasted more than 10 s (t-statistic=1.82, p=0.023). This was not reflected by changes in the monitor-derived respiratory rate and no episodes of apnoea were recorded in the medical records.ConclusionsWe show that our algorithm offers an improved method for the identification of IBIs and apnoeas in preterm infants. Following ROP screening, increased respiratory instability can occur even in the absence of clinically significant apnoeas. Accurate assessment of infant respiratory activity is essential to inform clinical practice.
Extracorporeal CO2removal in acute exacerbation of COPD unresponsive to non-invasive ventilation
Authors: Azzi Mathilde , Aboab Jerome , Alviset Sophie , Ushmorova Daria , Ferreira Luis , Ioos Vincent , Memain Nathalie , Issoufaly Tazime , Lermuzeaux Mathilde , Laine Laurent , Serbouti Rita , Silva Daniel 
Published: December 2021

BackgroundThe gold-standard treatment for acute exacerbation of chronic obstructive pulmonary disease (ae-COPD) is non-invasive ventilation (NIV). However, NIV failures may be observed, and invasive mechanical ventilation (IMV) is required. Extracorporeal CO₂ removal (ECCO₂R) devices can be an alternative to intubation. The aim of the study was to assess ECCO₂R effectiveness and safety.MethodsPatients with consecutive ae-COPD who experienced NIV failure were retrospectively assessed over two periods of time: before and after ECCO₂R device implementation in our ICU in 2015 (Xenios AG).ResultsBoth groups (ECCO₂R: n=26, control group: n=25) were comparable at baseline, except for BMI, which was significantly higher in the ECCO₂R group (30 kg/m² vs 25 kg/m²). pH and PaCO₂ significantly improved in both groups. The mean time on ECCO₂R was 5.4 days versus 27 days for IMV in the control group. Four patients required IMV in the ECCO₂R group, of whom three received IMV after ECCO₂R weaning. Seven major bleeding events were observed with ECCO₂R, but only three led to premature discontinuation of ECCO₂R. Eight cases of ventilator-associated pneumonia were observed in the control group. Mean time spent in the ICU and mean hospital stay in the ECCO₂R and control groups were, respectively, 18 vs 30 days, 29 vs 49 days, and the 90-day mortality rates were 15% vs 28%.ConclusionsECCO₂R was associated with significant improvement of pH and PaCO₂ in patients with ae-COPD failing NIV therapy. It also led to avoiding intubation in 85% of cases, with low complication rates.Trial registration numberClinicalTrials.gov,NCT04882410. Date of registration 12 May 2021, retrospectively registered.https://www.clinicaltrials.gov/ct2/show/NCT04882410.
Case for mandatory COVID-19 vaccinations for workers in health and aged care settings: a guide for leaders
Authors: Loh Erwin , Michael Sarah , Beetson Rob , Schmidt Annie 
Published: December 2021

BackgroundThis brief paper provides an overview of the analysis in support of mandating COVID-19 vaccinations for all workers in health and aged care settings in Australia. Leaders of health and aged care organisations have a duty of care under work health and safety legislation to eliminate and/or control the risk of transmission of vaccine-preventable disease in their facilities, including COVID-19.MethodsKey issues that should be considered by healthcare leaders when mandating that all health and aged care workers be vaccinated against COVID-19 were analysed by executives from a large Australian national health and aged care provider and discussed in this paper.ResultsThis paper summarises the medical/scientific, ethical, legal, work health and safety, workers’ compensation and industrial relations considerations when mandating COVID-19 vaccination for healthcare workers.ConclusionLeaders of health and aged care organisations must provide a safe environment and workplace for all those who work for them, as well as for those who receive care or treatment at one of their facilities. It is hoped that this paper will assist leaders of healthcare organisations in making their own decisions during this time.
Masses and strong decays of open charm hexaquark states $$\Sigma _{c}^{(*)}{\Sigma }_{c}^{(*)}$$
Authors: Ling Xi-Zhe , Liu Ming-Zhu , Geng Li-Sheng 
Published: December 2021

AbstractInspired by the recent discovery of the doubly charmed tetraquark state $$T_{cc}^{+}$$

T

cc

+

by the LHCb Collaboration, we perform a systematic study of masses and strong decays of open charm hexaquark states $${\Sigma }_{c}^{(*)}\Sigma _{c}^{(*)}$$

Σ

c

(

∗
)

Σ

c

(

∗
)

. Taking into account heavy quark spin symmetry breaking, we predict several bound states of isospin $$I=0$$

I
=
0

, $$I=1$$

I
=
1

, and $$I=2$$

I
=
2

in the one boson exchange model. Moreover, we adopt the effective Lagrangian approach to estimate the decay widths of $${\Sigma }_{c}^{(*)}\Sigma _{c}^{(*)} \rightarrow \Lambda _{c}\Lambda _{c}$$

Σ

c

(

∗
)

Σ

c

(

∗
)

→

Λ
c

Λ
c

and their relevant ratios via the triangle diagram mechanism, which range from a few MeV to a few tens of MeV. We strongly recommend future experimental searches for the $${\Sigma }_{c}^{(*)}\Sigma _{c}^{(*)}$$

Σ

c

(

∗
)

Σ

c

(

∗
)

hexaquark states in the $$\Lambda _c\Lambda _c$$

Λ
c

Λ
c

invariant mass distributions.
Explicit volume formula for a hyperbolic tetrahedron in terms of edge lengths
Authors: Abrosimov Nikolay , Vuong Bao 
Published: December 2021

We consider a compact hyperbolic tetrahedron of a general type. It is a convex hull of four points called vertices in the hyperbolic space [Formula: see text]. It can be determined by the set of six edge lengths up to isometry. For further considerations, we use the notion of edge matrix of the tetrahedron formed by hyperbolic cosines of its edge lengths. We establish necessary and sufficient conditions for the existence of a tetrahedron in [Formula: see text]. Then we find relations between their dihedral angles and edge lengths in the form of a cosine rule. Finally, we obtain exact integral formula expressing the volume of a hyperbolic tetrahedron in terms of the edge lengths. The latter volume formula can be regarded as a new version of classical Sforza’s formula for the volume of a tetrahedron but in terms of the edge matrix instead of the Gram matrix.
A study of alpha-decay using effective liquid drop model
Authors: Sridhara G. R. , Manjunatha H. C. , Sowmya N. , Gupta P. S. Damodara 
Published: December 2021

In this paper, we have made an attempt to analyze the alpha-decay half-lives of in the atomic number range [Formula: see text] by considering an effective liquid drop model. The role of pre-formation probability by including iso-spin effect is included during an evaluation of half-lives. We have also compared the studied alpha-decay half-lives with that of semi-empirical formulae such as Viola Seaborg semi-empirical formulae (VSS) [J. Inorg. Nucl. Chem. 28 (1966) 741; Nucl. Phys. A 848 (2010) 279], Royer formulae [J. Phys. G: Nucl. Part. Phys. 26 (2000) 1149; Phys. Rev. C 101 (2020) 034307] and also with that of the available experiments. From this comparison, it can be concluded that the effective liquid drop model produces an alpha-decay half-lives close to the experiments.
Dynamic Instability of Functionally Graded Carbon Nanotubes-Reinforced Composite Joined Conical-Cylindrical Shell
Authors: Uspensky B. , Avramov K. , Sakhno N. , Nikonov O. 
Published: December 2021

In this paper, dynamic instability of functionally graded carbon nanotubes (CNTs)-reinforced composite joined conical-cylindrical shell in supersonic flow is analyzed numerically. The higher-order shear deformation theory is applied to describe the stress–strain state of thin-walled structure. The assumed-mode method is used to derive the finite degrees-of-freedom dynamical system, which describes the structure motions. The structure motions are expanded by using the eigenmodes, which are obtained by the Rayleigh–Ritz method. The trial functions, which satisfy the continuity conditions at the cylindrical-cone junction, are used to obtain the eigenmodes. The properties of free vibrations of thin-walled structure are analyzed numerically. The dynamic instability of the joined conical-cylindrical shell in supersonic flow is analyzed using the characteristic exponents. As follows from the numerical study, the dynamic instability is arisen due to the Hopf bifurcation. The dependences of the supersonic flow critical pressure on the Mach number and the type of CNTs distribution are analyzed numerically.
Scratching the surface(s): examining the complexity of geological contexts for the Palaeolithic of the Sonar Basin, Madhya Pradesh
Authors: Pardiwalla Yezad 
Published: December 2021

Abstract
The Sonar River Valley is centrally located in Madhya Pradesh, flanked by rich Palaeolithic and fossiliferous localities in the Son and Narmada valleys and has historically been overlooked in favour of the latter rivers, which tend to preserve well-stratified Quaternary formations along varying portions of their length. Here an attempt is made to look at the Sonar Basin through a broader lens, examining the various landforms found in the district of Damoh through which the Sonar flows before joining the Ken. The objective of this paper is threefold: to bring together the geomorphology of the area both in association with and as a result of fluvial action but also as a product of other geomorphic processes; to understand the consequences these processes have for the visibility of the prehistoric archaeological record within the region; and to look at this geoarchaeological relationship in the wider context of some of the major river basins in Madhya Pradesh, notably the Son and Narmada. Secondary sources on geology and geoarchaeology have been integrated with preliminary fieldwork in Districts Damoh and Narsinghpur, and to a smaller extent in Sagar, Chhatarpur and Panna. This work demonstrates the complexity of the South Asian Palaeolithic record that stretches beyond fluvial contexts, in turn helping to spatially expand our understanding of hominin behaviour beyond narrow riverine corridors.
Early Pliocene marine transgression into the lower Colorado River valley, southwestern USA, by re-flooding of a former tidal strait
Authors: Dorsey Rebecca J. , Braga Juan Carlos , Gardner Kevin , McDougall Kristin , O'Connell Brennan 
Published: December 2021

Abstract

Marine straits and seaways are known to host a wide range of sedimentary processes and products, but the role of marine connections in the development of large river systems remains little studied. This study explores a hypothesis that shallow-marine waters flooded the lower Colorado River valley at
c.
5 Ma along a fault-controlled former tidal strait, soon after the river was first integrated into the northern Gulf of California. The upper bioclastic member of the southern Bouse Formation provides a critical test of this hypothesis. The upper bioclastic member contains wave ripple-laminated bioclastic grainstone with minor red mudstone, pebbly grainstone with hummocky cross-stratification (HCS)-like stratification and symmetrical gravelly ripples, and calcareous-matrix conglomerate. Fossils include upward-branching segmented coralline-like red algae with no known modern relatives but confirmed as marine calcareous algae, echinoid spines, barnacles, shallow-marine foraminifers, clams, and serpulid worm tubes. These results provide evidence for deposition in a shallow-marine bay or estuary seaward of the transgressive backstepping Colorado River delta. Tsunamis generated by seismic and meteorological sources likely produced the HCS-like and wave-ripple cross-bedding in poorly-sorted gravelly grainstone. Marine waters inundated a former tidal strait within a fault-bounded tectonic lowland that connected the lower Colorado River to the Gulf of California. Delta backstepping and transgression resulted from a decrease in sediment output due to sediment trapping in upstream basins and relative sea-level rise produced by regional tectonic subsidence.
Hunger Training as a Self-regulation Strategy in a Comprehensive Weight Loss Program for Breast Cancer Prevention: A Randomized Feasibility Study
Authors: Schembre Susan M. , Jospe Michelle R. , Bedrick Edward J. , Li Liang , Brewster Abenaa M. , Levy Erma , Dirba Danika D. , Campbell Morgan , Taylor Rachael W. , Basen-Engquist Karen M. 
Published: December 2021

Abstract

Weight losses &gt;10% favorably modulate biomarkers of breast cancer risk but are not typically achieved by comprehensive weight loss programs, including the Diabetes Prevention Program (DPP). Combining the DPP with hunger training (HT), an evidence-based self-regulation strategy that uses self-monitored glucose levels to guide meal timing, has potential to enhance weight losses and cancer-related biomarkers, if proven feasible. This two-arm randomized controlled trial examined the feasibility of adding HT to the DPP and explored effects on weight and metabolic and breast cancer risk biomarkers. Fifty postmenopausal women [body mass index (BMI) &gt;27 kg/m2)] at risk of breast cancer were randomized to the DPP+HT or DPP-only arm. Both arms followed a 16-week version of the DPP delivered weekly by a trained registered dietitian. Those in the DPP+HT also wore a continuous glucose monitor during weeks 4–6 of the program. Feasibility criteria were accrual rates &gt;50%, retention rates &gt;80%, and adherence to the HT protocol &gt;75%. All a priori feasibility criteria were achieved. The accrual rate was 67%, retention rate was 81%, and adherence to HT was 90%. Weight losses and BMI reductions were significant over time as were changes in metabolic and breast cancer risk biomarkers but did not vary by group. This trial demonstrated that HT was feasible to add to comprehensive weight management program targeted toward postmenopausal women at high risk of breast cancer, though upon preliminary examination it does not appear to enhance weight loss or metabolic changes.

Prevention Relevance:
This study found that it was feasible to add a short glucose-guided eating intervention to a comprehensive weight management program targeting postmenopausal women at high risk of breast cancer. However, further development of this novel intervention as a cancer prevention strategy is needed.
Wnt5a Promotes Lysosomal Cholesterol Egress and Protects Against Atherosclerosis
Authors: Awan Sara , Lambert Magalie , Imtiaz Ali , Alpy Fabien , Tomasetto Catherine , Oulad-Abdelghani Mustapha , Schaeffer Christine , Moritz Chloé , Julien-David Diane , Najib Souad , Martinez Laurent O. , Matz Rachel L. , Collet Xavier , Silva-Rojas Roberto , Böhm Johann , Herz Joachim , Terrand Jérôme , Boucher Philippe 
Published: December 2021

Background:
Impairment of cellular cholesterol trafficking is at the heart of atherosclerotic lesions formation. This involves egress of cholesterol from the lysosomes and 2 lysosomal proteins, the NPC1 (Niemann–Pick C1) and NPC2 that promotes cholesterol trafficking. However, movement of cholesterol out the lysosome and how disrupted cholesterol trafficking leads to atherosclerosis is unclear. As the Wnt ligand, Wnt5a inhibits the intracellular accumulation of cholesterol in multiple cell types, we tested whether Wnt5a interacts with the lysosomal cholesterol export machinery and studied its role in atherosclerotic lesions formation.

Methods:

We generated mice deleted for the
Wnt5a
gene in vascular smooth muscle cells. To establish whether Wnt5a also protects against cholesterol accumulation in human vascular smooth muscle cells, we used a CRISPR/Cas9 guided nuclease approach to generate human vascular smooth muscle cells knockout for Wnt5a.

Results:
We show that Wnt5a is a crucial component of the lysosomal cholesterol export machinery. By increasing lysosomal acid lipase expression, decreasing metabolic signaling by the mTORC1 (mechanistic target of rapamycin complex 1) kinase, and through binding to NPC1 and NPC2, Wnt5a senses changes in dietary cholesterol supply and promotes lysosomal cholesterol egress to the endoplasmic reticulum. Consequently, loss of Wnt5a decoupled mTORC1 from variations in lysosomal sterol levels, disrupted lysosomal function, decreased cholesterol content in the endoplasmic reticulum, and promoted atherosclerosis.

Conclusions:
These results reveal an unexpected function of the Wnt5a pathway as essential for maintaining cholesterol homeostasis in vivo.
Development and Validation of a Long-Term Incident Heart Failure Risk Model
Authors: Khan Sadiya S. , Ning Hongyan , Allen Norrina B. , Carnethon Mercedes R. , Yancy Clyde W. , Shah Sanjiv J. , Wilkins John T. , Tian Lu , Lloyd-Jones Donald M. 
Published: December 2021

Background:
Average lifetime risk for heart failure (HF) is high but differs significantly across and within sex-race groups. No models for estimating long-term risk for HF exist, which would allow for earlier identification and interventions in high-risk subsets. The authors aim to derive 30-year HF risk equations.

Methods:
Adults between the ages of 20 to 59 years and free of cardiovascular disease at baseline from 5 population-based cohorts were included. Among 24 838 participants (55% women, 25% Black based on self-report), follow-up consisted of 599 551 person-years. Sex- and race-specific 30-year HF risk equations were derived and validated accounting for competing risk of non-HF death. HF was based on a clinical diagnosis. Model discrimination and calibration were assessed using 10-fold cross-validation. Finally, the model was applied to varying risk factor patterns for systematic examination.

Results:

The rate of incident HF was 4.0 per 1000 person-years. Harrell C statistics were 0.82 (0.80–0.83) and 0.84 (0.82–0.85) in White and Black men and 0.84 (0.82–0.85) and 0.85 (0.83–0.87) in White and Black women, respectively. Hosmer-Lemeshow calibration was acceptable, with χ
2
<30 in all subgroups. Risk estimation varied across sex-race groups: for example, in an average 40-year-old nonsmoker with an untreated systolic blood pressure of 140 mm Hg and body mass index of 30 kg/m
2
, risk was estimated to be 22.8% in a Black man, 13.7% in a White man, 13.0% in a Black woman, and 12.1% in a White woman.

Conclusions:
Sex- and race-specific equations for prediction of long-term risk of HF demonstrated high discrimination and adequate calibration.
Cryoballoon Ablation for the Treatment of Atrial Fibrillation in Patients With Concomitant Heart Failure and Either Reduced or Preserved Left Ventricular Ejection Fraction: Results From the Cryo AF Global Registry
Authors: Rordorf Roberto , Scazzuso Fernando , Chun Kyoung Ryul Julian , Khelae Surinder Kaur , Kueffer Fred J. , Braegelmann Kendra M. , Okumura Ken , Al‐Kandari Fawzia , On Young Keun , Földesi Csaba ,   the Cryo AF Global Registry Investigators
Published: December 2021

Background
Heart failure (HF) and atrial fibrillation (AF) often coexist; yet, outcomes of ablation in patients with AF and concomitant HF are limited. This analysis assessed outcomes of cryoablation in patients with AF and HF.

Methods and Results

The Cryo AF Global Registry is a prospective, multicenter registry of patients with AF who were treated with cryoballoon ablation according to routine practice at 56 sites in 26 countries. Patients with baseline New York Heart Association class I to III (HF cohort) were compared with patients without HF. Freedom from atrial arrhythmia recurrence ≥30 seconds, safety, and health care utilization over 12‐month follow‐up were analyzed. A total of 1303 patients (318 HF) were included. Patients with HF commonly had preserved left ventricular ejection fraction (81.6%), were more often women (45.6% versus 33.6%) with persistent AF (25.8% versus 14.3%), and had a larger left atrial diameter (4.4±0.9 versus 4.0±0.7 cm). Serious procedure‐related complications occurred in 4.1% of patients with HF and 2.6% of patients without HF (
P
=0.188). Freedom from atrial arrhythmia recurrence was not different between cohorts with either paroxysmal AF (84.2% [95% CI, 78.6–88.4] versus 86.8% [95% CI, 84.2–89.0]) or persistent AF (69.6% [95% CI, 58.1–78.5] versus 71.8% [95% CI, 63.2–78.7]) (
P
=0.319). After ablation, a reduction in AF‐related symptoms and antiarrhythmic drug use was observed in both cohorts (HF and no‐HF), and freedom from repeat ablation was not different between cohorts. Persistent AF and HF predicted a post‐ablation cardiovascular rehospitalization (
P
=0.032 and
P
=0.001, respectively).

Conclusions
Cryoablation to treat patients with AF is similarly effective at 12 months in patients with and without HF.

Registration

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT02752737.
Calcatedessa gen.n. a new genus sister to Grammedessa Correia & Fernandes (Heteroptera, Pentatomidae, Edessinae) based on a cladistic analysis
Authors: da Silva Paulo Augusto Lima , Fernandes José Antônio Marin 
Published: December 2021

Abstract
Grammedessa Correia & Fernandes, 2016 is a genus raised to include some species of Edessa Fabricius, 1803 that is a very common group of stink bugs inhabiting only the Neotropical region. Grammedessa was proposed excluding a few species that were morphologically similar but not completely fitting in the diagnostic requirements of the genus. Grammedessa was also proposed without considering a phylogenetic context. In this work, the monophyly of Grammedessa was tested using a cladistic analysis, including all species that were originally excluded, under both Maximum Parsimony and Bayesian methods. As a result, six new species are now included in Grammedessa, which will be described in a forthcoming paper; Edessa botocudo Kirkaldy, 1909 was considered an unnecessary new name for Edessa hamata Walker, 1868 that was transferred to Grammedessa, resulting in G. hamata (Walker, 1868) comb.n.
Calcatedessa
gen.n., a new genus sister to Grammedessa, is here proposed to include four new species: C. anthomorpha
sp.n., C. clarimarginata
sp.n., C. germana
sp.n. and C. temnomarginata
sp.n. The Calcatedessa–Grammedessa clade and both genera were recovered as monophyletic by Maximum Parsimony and Bayesian methods. An identification key to the species of Calcatedessa
gen.n. is provided. The new genus is distributed in Guyana, Suriname, French Guyana, and Brazil.