bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penanaman Karakter Asma’ul Husna pada Anak Usia Dini di PAUD ELPIST Temanggung
Authors: Hartati Yuni Setya , Dewi Puteri Anggita , Ifadah Luluk 
Published: October 2021

Penelitian ini bertujuan menggambarkan penanaman nilai karakter Asma’ul Husna pada anak usia dini di PAUD Elpist Kabupaten Temanggung. Pertanyaan penelitian adalah bagaimana PAUD Elpist menanamkan nilai karakter Asma’ul Husna kepada peserta didiknya, faktor-faktor apakah yang mendukung maupun menghambatnya. Hasil penelitian menunjukkan bahwa dalam usaha penanaman nilai-nilai karakter Asma’ul Husna pada peseta didiknya, PAUD Elpist Temanggung memadukan kurikulum dari Yayasan yang berbasis Ahlus sunnah wal jamaah an nahdliyah, dan kemendiknas dengan menggunakan beragam metode. Faktor pendukung dalam implementasi ini adalah para guru memiliki pengetahuan dan motivasi yang tinggi serta sarana prasarana yang memadai. Sedangkan faktor penghambatnya adalah adanya wali murid yang kurang respek tehadap anak, serta minimnya buku atau artikel yang bisa diakses pendidik dalam memilih metode yang tepat. Sebagai rekomendasi agar Yayasan dan pengelola memfasilitasi kegiatan parenting yang melibatkan orang tua, serta memfasilitsi guru dengan buku-buku, atikel tentang metode-metode penerapan nilai kaakter Asma’ul Husna dan pelatihan-pelatihan yang relevan.
REPRESENTASI KEKERASAN DALAM NOVEL LAUT BERCERITA KARYA LEILA S. CHUDORI (REPRESENTATION OF VIOLENCE IN LAUT BERCERITA NOVEL BY LEILA S. CHUDORI)
Authors: Rahmi Yulina 
Published: October 2021

AbstractRepresentation of Violence in Laut Bercerita Novel by Leila S. Chudori. This study aims to describe the forms of violence and resistance in the novel Laut Bercerita by Leila S. Chudori. The description is done by discourse analysis. Critical discourse analysis examines various social forms and their imbalances displayed through text, then relates them to social and political contexts. This research uses descriptive qualitative method with Norman Fairclough's critical discourse analysis approach Based on the analysis, there are three types of violence, namely physical, verbal, and bureaucratic violence. The form of physical violence are beatings and torture. The form of verbal violence are to accuse and ridicule. Bureaucratic violence is shown in the form of a prohibition on joining a formal institution for people with a certain background and the prohibition of staging theater or poetry which are considered to carry certain ideologies. Meanwhile, there are two types of resistance representations, namely open resistance and closed resistance. Open resistance is shown in the form of demonstrations. Closed resistance is shown in the form of resistance to categories imposed on society. Key words: discourse practice, violence, representation AbstrakRepresentasi Kekerasan dalam Novel Laut Bercerita Karya Leila S. Chudori. Penelitian ini bertujuan untuk mendeskripsikan wujud kekerasan dan perlawanan dalam novel Laut Bercerita karya Leila S. Chudori. Deskripsi tersebut dilakukan dengan analisis wacana. Analisis wacana kritis mengkaji beragam bentuk sosial dan ketimpangannya yang ditampilkan melalui teks, kemudian menghubungkannya dengan konteks sosial dan politik. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan analisis wacana kritis Norman Fairclough. Berdasarkan hasil analisis, terdapat tiga jenis kekerasan, yaitu kekerasan fisik, verbal, dan birokratik. Kekerasan fisik dengan wujud pemukulan dan penganiayaan. Kekerasan verbal dengan wujud menuduh dan mengejek. Kekerasan birokratik ditunjukkan dalam wujud larangan bergabung dengan suatu institusi formal bagi orang dengan latar belakang tertentu dan larangan pementasan seni teater atau puisi yang dianggap membawa ideologi tertentu. Sedangkan, representasi perlawanan terdapat dua jenis, yaitu perlawanan terbuka dan perlawanan tertutup. Perlawanan terbuka ditunjukkan dalam wujud demonstrasi. Perlawanan tertutup yang ditunjukkan dalam bentuk penolakan terhadap kategori-kategori yang dipaksakan terhadap masyarakat. Kata-kata kunci: wacana kritis, kekerasan, representasi
Development of a Knee Arthroplasty Episode-Based Cost Measure for Evaluating Cost in the Merit-Based Incentive Payment System
Authors: Choradia Nirmal , Lam Joyce , Luo Binglie , Bounds Sam , Yates Adolph J. , Quintana Juan , Do Rose , Feinberg Laurie , Sandhu Alex , Vail Daniel , MaCurdy Tom , Nagavarapu Sriniketh , Bhattacharya Jay 
Published: October 2021

Background:
Under the Merit-based Incentive Payment System (MIPS), the U.S. Centers for Medicare and Medicaid Services (CMS) evaluate clinicians who manage Medicare patients on the basis of cost and quality outcomes. CMS contractor Acumen, LLC, convened an expert panel to develop a knee arthroplasty episode-based cost measure (EBCM) for use in the MIPS.

Methods:
A Clinical Subcommittee of 28 clinician experts affiliated with 27 specialty societies provided guidance in developing the knee arthroplasty EBCM. The Clinical Subcommittee specified all aspects of the EBCM including triggering of the episode, services within the episode, risk adjustment, subgrouping, and exclusions. Services were counted only if the Clinical Subcommittee deemed them under the influence of the clinician assigned to the EBCM (selective service assignment; SSA). We assessed the reliability of the EBCM and compared it with an alternative population-based cost measure constructed without SSA.

Results:
We identified 249,301 knee arthroplasty episodes from June 1, 2016, to May 31, 2017, with 10,681 clinicians having at least 10 attributed episodes. The mean episode cost was $19,321 with a standard deviation of $1,816. SSA increased the reliability score from 0.71 to 0.81 relative to an alternative measure that counted all patient costs. SSA also led to reclassification of 41.8% of clinicians into different quintiles of performance.

Conclusions:
We found that the use of SSA in the creation of the EBCM substantially reduces random noise (i.e., unrelated medical procedures or costs) and offers a tool for assessing clinicians’ costs of management that is focused on care directly related to knee arthroplasty.
Treatment Outcomes of 125I Low-Dose-Rate Brachytherapy vs Radical Prostatectomy for Patients with Intermediate-Risk Prostate Cancer
Authors: Zhou Zhien , Liang Zhen , Zhou Yi , Yan Weigang , Wu Xingcheng , Zheng Zhibo , Zhang Fuquan , Ji Zhigang , Li Hanzhong , Wang Juan 
Published: October 2021

Abstract
Objective: To compare the efficacy of radical prostatectomy vs low-dose-rate brachytherapy for patients with intermediate-risk prostate cancer.Materials and methods: A retrospective analysis was performed on 361 intermediate-risk prostate cancer patients who underwent treatment from January 2010 and August 2019. 160 underwent radical prostatectomy and 201 underwent low-dose-rate brachytherapy using Iodine-125. Biochemical failure for radical prostatectomy was defined as prostate-specific antigen levels > 0.2 ng/ml, and for low-dose-rate brachytherapy as nadir PSA level + 2 ng/ml. The log-rank test compared biochemical relapse-free survival between the two modalities, and Cox regression identified factors associated with biochemical relapse-free survival.Results: Median follow-up was 54 months for radical prostatectomy and 69 months for low-dose-rate brachytherapy. The 5-and 8-year biochemical relapse-free survival rates were 70.2% and 63.1% in the radical prostatectomy group, and 83.2% and 68.9% in the low-dose-rate brachytherapy group, respectively, P=0.003. There were no significant differences in terms of clinical relapse-free survival, cancer-specific survival or overall survival between the two groups. Conclusion: Low-dose-rate brachytherapy is a reasonable treatment option for intermediate-risk prostate cancer patients, yielding improved biochemical relapse-free survival and equivalent rates of clinical relapse-free survival, cancer-specific survival and overall survival compared with radical prostatectomy.
Loss of Monoacylglycerol O-Acyltransferase 2 can be Compensated for by Diacylglycerol O-Acyltransferases 1 and 2 in High-Fat Diet-Induced Obesity and Mammary Cancer Development
Authors: Mei Yan , Wang Jing , Lu Jia-Bin , Lu Guan-Ming , Peng Li-Xia , Lang Yan-Hong , Zheng Li-Sheng , Huang Bi-Jun , Shi Yan-Xia , Qian Chaonan 
Published: October 2021

Abstract
Background: Dietary fat absorption involves the re-esterification of digested triacylglycerol in the enterocytes, it is a biological process catalyzed by monoacylglycerol O-acyltransferase 2 (MOGAT2, aka MGAT2), which is highly expressed in the small intestine. A previous study showed that the loss of the Mogat2 gene can prevent high-fat diet-induced obesity in mice. Obesity is associated with an increased risk of several types of cancer including postmenopausal breast cancer.Methods: We collected 147 patients with triple negative breast adenocarcinoma to explore the relationship between the expression of MOGAT2 and patient overall survival. And we generated a Mogat2-deficient mouse mammary tumor model by crossing Mogat2-deficient mice with MMTV-PyMT mice to examine the effect of losing MOGAT2 in vivo.Results: Our founding suggest that obesity was induced by a relatively high-fat diet (37% of calories from fat) in the mice with or without Mogat2 knockout. Mammary tumor development was deteriorated by a relatively high-fat diet regardless of Mogat2 deficiency. As a compensation mechanism, upregulation of diacylglycerol O-acyltransferases 1 and 2 (Dgat1 and Dgat2) in the Mogat2 deficient mice was found. Conclusions: Elevated expression of MOGAT2 in triple negative breast adenocarcinoma predicts poorer patient overall survival. With the compensation of Dgat1 and Dgat2, Mogat2 deficiency alone cannot prevent fat diet-induced obesity, nor prevent mammary tumor development in a mouse model.
Physiological and metabolic alterations induced by commercial neonicotinoid formulations in Daphnia magna
Authors: Farkas Anna , Somogyvári Dávid , Kovács Attila W. , Mörtl Mária , Székács András , Győri János 
Published: October 2021

Abstract
Neonicotinoid insecticides are widely used agents in agriculture to control a broad range of insect pests. Although use of neonicotinoid pesticides has resulted in the widespread contamination of surface waters, sublethal toxicity data of these products in relation to non-target aquatic biota are still poor. Therefore, the objective of this study was to assess the effects of two neonicotinoid pesticides with widespread use on the basic physiological functions: the thoracic limb activity and heart rate of Daphnia magna, and to screen for their potential to affect the cytochrome P450 monooxygenase system of daphnids. The considered pesticides were the acetamiprid- and thiacloprid based products Mospilan 20 SG and Calypso 480 SC. The dose-dependent variation in the three biological endpoints considered were assessed following 24h exposures. The two neonicotinoid formulations elicited significant depression on the thoracic limb activity and heart rate of daphnids at doses close to the 48h-EC50 of the products, a response mainly attributable to the overall drop in the general health status of the organisms. The dose related variation in the ECOD activity of daphnids exposed to the selected neonicotinoid formulations followed a biphasic pattern, with starting effective doses for Mospilan 20 SG of 6.3 mg L-1 (= 1/20 of 48h-EC50 for Daphnia neonates), and for Calypso 480 SC of 0.034 mg L-1 (= 1/4000 of 48h-EC50). Maximal ECOD activity (2.2 fold increase vs. controls) was induced by Mospilan 20 SG in daphnids exposed to 114 mg L-1 product (= 48h-EC20), and by Calypso 480 SC (1.8 fold increase) at 5.2 mg L-1 dose (= 1/20 of 48h-EC50). The results outlined significant alterations in the physiological traits considered at concentrations below the immobility thresholds (48h-EC50) of the products used as benchmarks to rate their toxicity risks to aquatic biota. Therefore, we think our findings might deserve consideration in the environmental risk evaluation of these products.
Physics informed deep learning to super-resolve and cross-calibrate solar magnetograms
Authors: Munoz-Jaramillo Andres , Jungbluth Anna , Gitiaux Xavier , Wright Paul , Shneider Carl , Maloney Shane , Baydin Atılım Güneş , Gal Yarin , Deudon Michel , Kalaitzis Freddie 
Published: October 2021

Abstract
Super-resolution techniques aim to increase the resolution of images by adding detail. Compared to upsampling techniques reliant on interpolation, deep learning-based approaches learn features and their relationships across the training data set to leverage prior knowledge on what low resolution patterns look like in higher resolution images.

As an added benefit, deep neural networks can learn the systematic properties of the target images (i.e.\ texture), combining super-resolution with instrument cross-calibration. While the successful use of super-resolution algorithms for natural images is rooted in creating perceptually convincing results, super-resolution applied to scientific data requires careful quantitative evaluation of performances.
In this work, we demonstrate that deep learning can increase the resolution and calibrate space- and ground-based imagers belonging to different instrumental generations. In addition, we establish a set of measurements to benchmark the performance of scientific applications of deep learning-based super-resolution and calibration.
We super-resolve and calibrate solar magnetic field images taken by the Michelson Doppler Imager (MDI; resolution ~2"/pixel; science-grade, space-based) and the Global Oscillation Network Group (GONG; resolution ~2.5"/pixel; space weather operations, ground-based) to the pixel resolution of images taken by the Helioseismic and Magnetic Imager (HMI; resolution ~0.5"/pixel; last generation, science-grade, space-based).
Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma
Authors: Wang Gongjun , Sun Libin , Wang Shasha , Guo Jing , Li Hui , Xiao Ruoxi , Li Wenqian , Lv Jing , Qiu Wensheng , Qi Weiwei 
Published: October 2021

Abstract
Background: Ferroptosis is a form of cell death involved in diverse physiological context. Increasing evidence suggests that there is a closely regulatory relationship between ferroptosis and long noncoding RNAs (lncRNAs).Method: RNA-sequencing data from The Cancer Genome Atlas (TCGA) data resource and ferroptosis-related genes from FerrDb (http://www.zhounan.org/ferrdb/) data resource were employed to select differentially expressed lncRNAs. We performed Univariate Cox regression and multivariate Cox analyses analysis on these differentially expressed lncRNAs to screen independent predictive factors. Subsequently, we established two signatures for predicting overall survival (OS) and progression-free survival (PFS). Finally, experiments were conducted to verify the roles of LASTR in gastric cancer (GC).Results: We identified 12 differentially expressed lncRNAs linked with OS and 13 associated with PFS. Kaplan-Meier(K-M) analyses exhibited that the high-risk group was related to a poor prognosis of stomach adenocarcinoma (STAD). The AUCs of the OS, as well as PFS signatures of lncRNAs were 0.734 and 0.771, respectively, indicating their excellent efficacy in predicting STAD prognosis. Our experimental results illustrated that the inhibition of LASTR inhibited tumor proliferation and migration in GC.Conclusion: This comprehensive evaluation of the ferroptosis-related lncRNA landscape in STAD unearthed novel lncRNAs related to carcinogenesis. In addition, we also experimentally confirmed the effects of LASTR on proliferation, migration and ferroptosis. These results provide potential novel targets for tumor treatment and promote personalized medicine.
Electric double layer structure in aqueous electrolyte and its electrocatalytic importance
Authors: Shin Seung-Jae , Kim Dong Hyun , Bae Geunsu , Ringe Stefan , Choi Hansol , Lim Hyung-Kyu , Choi Chang Hyuck , Kim Hyungjun 
Published: October 2021

Abstract
To design electrochemical interfaces for efficient electric-chemical energy interconversion, it is critical to reveal the electric double layer (EDL) structure and relate it with electrochemical activity; nonetheless, this has been a long-standing challenge. Of particular, no molecular-level theories have fully explained the characteristic two peaks arising in the potential-dependence of the EDL capacitance, which is sensitively dependent on the EDL structure. We herein demonstrate that our first-principles-based molecular simulation reproduces the experimental capacitance peaks. The origin of two peaks emerging at anodic and cathodic potentials is unveiled to be an electrosorption of ions and an EDL structural phase transition, respectively. We further find a cation complexation gradually modifies the EDL structure and the field strength, which linearly scales the carbon dioxide reduction activity. This study deciphers the complex structural response of the EDL and highlights its catalytic importance, which bridges the mechanistic gap between the EDL structure and electrocatalysis.
Hiking and Livestock Favor Non-Native Plants in The High Andes
Authors: Alvarez María Alisa , Barros Ana Agustina , Vázquez Diego Pedro , Bonjour Lorena de Jesús , Lembrechts Jonas , Wedegärtner Ronja , Aschero Valeria 
Published: October 2021

Abstract
Hikers and livestock using mountain trails damage native vegetation and act as seed vectors, thus favouring the spread of non-native plants. We evaluated the effect of trails and livestock abundance on the success of non-native plants in the arid central Andes of Argentina. We surveyed six trails, covering elevations between 2400 m and 3570 m a.s.l. and recorded non-native and native vegetation using transects distributed along the elevational gradient and spanning distances up to 22 m from the trail. We assessed how non-native occurrence, richness and cover varied with distance from the trail, intensity of use by livestock, native plant community composition and elevation. We found that trails favoured non-native occurrence, but did not influence richness and cover, while livestock favoured non-native occurrence, richness and cover. Non-native richness and cover decreased with elevation and varied with native community composition. In addition, non-native richness was positively correlated with native shrub cover suggesting possible facilitative interactions. Our results show that despite strong environmental filtering that decreases non-native abundance with elevation, non-natives occur up to the upper limits of vegetation, and that trails and livestock favour their spread in the mountains.
Magnitude of Preterm Birth Admissions, Immediate Outcomes And Their Predictors In Debre Markos Referral Hospital, North West, Ethiopia, 2019.
Authors: Assefa Birtukan , Abate Abebe , Yirga Tadesse 
Published: October 2021

Abstract
Background: Each year 15 million preterm babies are born. Pre-term birth complications account for 35% of the estimated 3.1 million global neonatal deaths and are the second leading cause of death in children less than 5 years aged.Objective: we assessed the magnitude of preterm birth admissions, immediate outcomes and their predictors in Debre Markos Referral Hospital, North West, Ethiopia, 2019. Methodology: An institutional based retrospective cross- sectional study design was conducted. Bivariable and multivariable logistic regression analysis were done. Variables with p value <0.05 in multivariate analysis were declared as statistically significant at a 95% confidence interval. Results: Out of 212 neonates involved in the study, 27.8% were preterm birth admissions. From this 36.3% of neonates was died before discharge. Hypertension during pregnancy was significantly associated with preterm admissions (P= 0.013, AOR= 4.464, 95% CI: (1.375, 14.498)) and being extreme low and very low birth weight (P= 0.005, AOR= 2.107, 95% CI: (0.023, 0.508)), and those preterm babies with low APGAR score (P= 0.016, AOR= 3.113, 95% CI: (0.019, 0.669)) were significantly associated with death before discharge. Conclusion: Preterm admissions accounted for a significant percentage of neonatal admissions with significant death outcomes. Maternal medical problems like hypertension during pregnancy was significantly associated with preterm admissions. Also, preterm babies with extreme low birth weight and very low birth weight, low APGAR score were significantly associated with death outcome. Therefore, strategies should be designed to prevent preterm birth and their complications.
Metataxonomic Review To Elucidate The Role of The Microbiome In Celiac Disease Across The Gastrointestinal Tract.
Authors: Arcila Juliana , Loria-Kohen Viviana , de Molina Ana Ramírez , Pau Enrique Carrillo de Santa , Zambrano Laura Judith Judith 
Published: October 2021

Abstract
Background: Dysbiosis of the microbiome has been related to the Celiac disease (CeD) progress, an autoimmune disease characterised by gluten intolerance developed in genetically susceptible individuals under certain environmental factors. The microbiome contributes to CeD pathophysiology modulating the immune response by the action of short-chain fatty acids (SCFA), affecting gut barrier integrity allowing the entrance of gluten derived proteins, and degrading immunogenic peptides of gluten through endoprolyl peptidase enzymes. Results: We reviewed state of the art in taxonomic composition for CeD and compiled the larger dataset of 16S prokaryotic ribosomal RNA (rRNA) gene high-throughput sequencing for consensus profiling. We present for the first time an integrative analysis of metataxonomic data from CeD patients, including samples from different body sites (saliva, pharynx, duodenum, and stool). We found the presence of coordinated changes through the gastrointestinal tract characterised by an increase in Actinobacteria species in the upper tract (pharynx and duodenum), and an increase in Proteobacteria in the lower tract (duodenum and stool), as well as site-specific changes evidencing a dysbiosis in CeD patients' microbiota. Moreover, we described the effect of adherence to a gluten-free diet (GFD) evidenced by an increase in beneficial bacteria and a decrease in some Betaproteobacteriales but not fully restoring CeD-related dysbiosis. Conclusions: We illustrate that the gut microbiota acts as an enhancer of immune response in CeD through the production of lipopolysaccharides and other bacterial components that activate the immune response and by decrease SCFA producers bacteria. Furthermore, microbial changes observed through the gastrointestinal tract of CeD patients may help manage the disease and follow-up GFD treatment.
Electrocatalysts derived from copper complexes transform CO into C2+ products effectively in a flow cell
Authors: Ren Shaoxuan , Zhang Zishuai , Lees Eric , Fink Arthur , Melo Luke , Hunt Camden , Dvorak David , Wu Wen Yu , Grant Edward , Berlinguette Curtis 
Published: October 2021

Abstract
The highest performance flow cells capable of electrolytically converting CO2 into higher value chemicals and fuels pass a concentrated hydroxide electrolyte across the cathode. A major problem for CO2 electrolysis is that this strongly alkaline medium converts the majority of CO2 into unreactive HCO3– and CO32– rather than CO2 reduction reaction (CO2RR) products. The electrolysis of CO (instead of CO2) does not suffer from this same problem because CO does not react with hydroxide. Moreover, CO can be more readily converted into products containing two or more carbon atoms (i.e., C2+ products). While several solid-state electrocatalysts have proven competent at converting CO into C2+ products, we demonstrate here that molecular electrocatalysts are also effective at mediating this transformation in a flow cell. Using a molecular copper phthalocyanine (CuPc) electrocatalyst, CO was electrolyzed into C2+ products at high rates of product formation (i.e., current densities J ≥200 mA/cm2), and at high Faradaic efficiencies for C2+ production (FEC2+; 72% at 200 mA/cm2). These findings present a new class of electrocatalysts for making carbon-neutral chemicals and fuels.