bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary genome detection and tracking of Hantaan virus from hemorrhagic fever with renal syndrome patients using multiplex PCR-based next-generation sequencing
Authors: Cho Seungchan , Kim Won-Keun , No Jin Sun , Lee Seung-Ho , Jung Jaehun , Yi Yongjin , Park Hayne Cho , Lee Geum-Young , Park Kyungmin , Kim Jeong-Ah , Kim Jongwoo , Lee Jingyeong , Lee Daesang , Song Dong Hyun , Gu Se Hun , Jeong Seong Tae , Song Jin-Won 
Published: September 2021

Background
Hantavirus infection occurs through the inhalation of aerosolized excreta, including urine, feces, and saliva of infected rodents. The presence of Hantaan virus (HTNV) RNA or infectious particles in urine specimens of patient with hemorrhagic fever with renal syndrome (HFRS) remains to be investigated.

Methodology/Principal findings
We collected four urine and serum specimens of Republic of Korea Army (ROKA) patients with HFRS. We performed multiplex PCR-based next-generation sequencing (NGS) to obtain the genome sequences of clinical HTNV in urine specimens containing ultra-low amounts of viral genomes. The epidemiological and phylogenetic analyses of HTNV demonstrated geographically homogenous clustering with those in Apodemus agrarius captured in highly endemic areas, indicating that phylogeographic tracing of HTNV genomes reveals the potential infection sites of patients with HFRS. Genetic exchange analyses showed a genetic configuration compatible with HTNV L segment exchange in nature.

Conclusion/Significance
Our results suggest that whole or partial genome sequences of HTNV from the urine enabled to track the putative infection sites of patients with HFRS by phylogeographically linking to the zoonotic HTNV from the reservoir host captured at endemic regions. This report raises awareness among physicians for the presence of HTNV in the urine of patients with HFRS.
Prevalence of complementary and alternative medicine despite limited perceived efficacy in patients with rheumatic diseases in Mexico: Cross-sectional study
Authors: Caballero-Hernández Claudia Isabel , González-Chávez Susana Aideé , Urenda-Quezada Adelfia , Reyes-Cordero Greta Cristina , Peláez-Ballestas Ingris , Álvarez-Hernández Everardo , Pacheco-Tena César 
Published: September 2021

Introduction
Complementary and alternative medicine (CAM) is frequently used by patients with rheumatic diseases (RD) to improve their symptoms; however, its diversity and availability have increased notably while scientific support for its effectiveness and adverse effects is still scarce.

Objective
To describe the prevalence and diversity of CAM in patients with RD in Chihuahua, Mexico.

Methods
A cross-sectional study was conducted in 500 patients with RD who were interviewed about the use of CAM to treat their disease. The interview included sociodemographic aspects, characteristics of the disease, as well as a description of CAM use, including type, frequency of use, perception of the benefit, communication with the rheumatologist, among others.

Results
The prevalence of CAM use was reported by 59.2% of patients, which informed a total of 155 different therapies. The herbal CAM group was the most used (31.4%) and included more than 50 different therapies. The use of menthol-based and arnica ointments was highly prevalent (35%). Most patients (62.3%) reported very little or no improvement in their symptoms. Only a fourth of the patients informed the rheumatologist of the use of CAM. The use of CAM was influenced by female sex, university degree, diagnosis delay, lack adherence to the rheumatologist’s treatment, family history of RD, and orthopedic devices.

Conclusion
The use of CAM in our population is highly prevalent and similar to reports in different populations suggesting a widespread use in many different societies. We found high use of herbal remedies; however, there were many different types suggesting a lack of significant effect. Patients continue using CAM despite a perception of no-effectiveness. Recurrent use of CAM is explained by factors other than its efficacy.
Time-trend in excess weight in Brazilian adults: A systematic review and meta-analysis
Authors: Kodaira Katia , Abe Flavia Casale , Galvão Tais Freire , Silva Marcus Tolentino 
Published: September 2021

Background
This review aimed to estimate the time-trend prevalence of excess weight, overweight and obesity in the Brazilian adult population, from the 1970s–2020, through systematic review and meta-analysis (Protocol: CRD42018091002).

Methods
A search for articles was conducted in the databases MEDLINE, EMBASE, Scopus, and LILACS up to June 2021. Studies that assessed excess weight, overweight and obesity in the adult population were eligible. Two authors selected studies, collected data and assessed the methodological quality of the studies. The primary outcomes were the prevalence of excess weight, overweight, and obesity by sex and period of years. Pooled prevalence and 95% confidence intervals (CIs) were calculated in the meta-analysis of the random effects model. Heterogeneity (I2) was investigated by meta-regression and publication bias was investigated by Egger’s test.

Results
A total of 7,938 references were identified in the search strategies, of which eighty-nine studies and nine national surveys, conducted from 1974–2020, were included in the meta-analysis. The pooled prevalence of excess weight in Brazilian adults increased from 33.5% (95% CI: 25.0; 42.6%) in 1974–1990 to 52.5% (95% CI: 47.6; 57.3%) in 2011–2020. The pooled prevalence of overweight in Brazilian adults was 24.6% (95% CI: 18.8; 31.0%) from 1974–1990 and 40.5% (95% CI: 37.0; 43.9%) from 2011–2020. The pooled prevalence of obesity in Brazilian adults increased by 15.0% from 1974–1990 to 2011–2020. The increases were observed for both men and women in almost all periods. The prevalence of excess weight and obesity remained higher among women in all periods.

Conclusions
A continuous increase in the prevalence of excess weight, overweight and obesity were observed over the years. The prevalence of excess weight affected half of Brazilian adults in the period from 2011–2020 and both sexes.
Retos de los centros educativos transfronterizos de Portugal y Espan?a a favor de las “Competencias para el siglo XXI”
Authors: Milheiro Silva Ana , García-Docampo Laura , Marques Silva Sofia , Lorenzo Moledo María Mar 
Published: September 2021

En el ámbito del Marco Estratégico de Educación y Formación 2020, la recomendación de Competencias para el siglo XXI define competencias clave que los centros educativos de los estados miembros de la Unión Europea deben desarrollar con niños y jóvenes. Este artículo explora el trabajo de los centros públicos de educación secundaria ubicados en los territorios fronterizos del norte de Portugal-Galicia (España) en torno a dichas competencias.
Las regiones fronterizas Portugal-España presentan ciertas desigualdades sociales, económicas, culturales y educativas, pero también la posibilidad de dinámicas locales prometedoras y de cooperación transfronteriza. A su vez, los centros educativos se encuentran, en estos territorios, con menos oportunidades ante el reto de dar respuesta a las Competencias para el siglo XXI, entendiendo estas como el conjunto de conocimientos, habilidades, actitudes y valores que permite al alumnado construir su lugar como sujeto en una sociedad en continuo cambio.
El objetivo de este artículo es comprender cómo estos centros organizan su acción educativa para el desarrollo de estas competencias, analizando sus documentos escolares. Para ello, se realizó un estudio cualitativo con análisis de contenido temático de veintidós documentos oficiales (once portugueses y once españoles) mediante un proceso cuidadoso de lectura flotante, codificación, categorización e interpretación.
Los resultados indican que los centros analizados recogen estas competencias en sus documentos, sin embargo, también se verifica que no son una prioridad y no presentan muchas estrategias para su desarrollo. Entre las categorías de competencias analizadas, se destaca que las habilidades para la vida son las más presentes en los proyectos educativos de los centros portugueses y españoles, coincidiendo con las que tienen mayor presencia en los documentos que a nivel nacional orientan los sistemas educativos. Este estudio propone una articulación entre las recomendaciones educativas globales, europeas, nacionales y locales, teniendo en cuenta las especificidades de las escuelas fronterizas.
Identidad narrativa en la relación educativa: promesa, solicitud y don
Authors: Moreno Aponte Rodrigo , Vila Merino Eduardo S. 
Published: September 2021

En este artículo se propone la posibilidad de relacionar la propuesta filosófica de Paul Ricoeur sobre el sí mismo con la experiencia ética de la educación. Se parte de la propuesta de la identidad narrativa que se construye en medio de una trama en la que el sujeto cambia a medida que ésta se desarrolla (identidad ipse), a diferencia de una identidad fija e inmutable (identidad ídem). La educación en este plano narrativo se presenta como un espacio de conversación donde la experiencia del educador y educando cobra relevancia. A partir de esto, el texto se dirige a los conceptos de solicitud, promesa y don que tienen como eje el reconocimiento y la mutualidad entre el sí mismo y el otro. La relación ética de la solicitud no espera el reconocimiento del otro al sí mismo. El movimiento que se plantea del sí mismo hacia el otro lleva implícita una mutualidad que significa un dar sin esperar el retorno de una respuesta. La síntesis de estos conceptos lleva a plantear la posibilidad de una pedagogía de la ipseidad. Aquí, la relación entre educador y educando se cohesiona en el reconocimiento mutuo a partir del desarrollo de su identidad narrativa. La relación educativa acontece en medio de la solicitud que el sí mismo hace del otro. La educación vista desde la solicitud en la construcción de la identidad ipse permite ver la experiencia de la escuela como algo inacabado y en cambio constante. La mutualidad en la escuela propicia el intercambio de dones. De esta manera, una perspectiva narrativa mediada por el reconocimiento mutuo es un lugar propicio para el acontecimiento ético de la alteridad en la acción educativa.
The Effectiveness of Peace Education Program on the Preschoolers’ Social Behaviour in the Sultanate of Oman
Authors: Rashid Al Mushaqiri Mahfouda , Bin Ishak Zahari , Muin Ismail Wail 
Published: September 2021

Purpose – This research aims to measure the effects of the peace education program on the social and emotional behaviours of preschool children in the Sultanate of Oman. Children should be equipped with basic values, such as respecting the efforts and ideas of others, forming a comprehensive and positive relationship with people, possessing the skills of empathy, and resolving conflicts in peaceful ways.Design/methods/approach – The researcher adopted the quasi-experimental approach, and the current study presented the Peace Education Program (PEP) for children aged 4–6 years in the Sultanate of Oman. The participants consisted of 40 children in the experimental group and 40 children in the control group. The researcher used a scale with picture choice questions containing two pictures per question to measure the behaviours of children before and after the treatments. The peace education program for the study also included 28 training sessions that were presented for 15 weeks at a duration of one hour per session.Findings – The current study results also favoured the experimental group, as an improvement in their social behaviour was observed after joining the program.Research implications/limitations – The research demonstrates that peace is a key prerequisite for developing a balanced life, especially in childhood. The results may be of great significance in measuring and improving children's behaviour through (PEP).Practical implications – The study findings may likely be fruitful to Oman's pupils, educators, curriculum designers, and educational policy-makers.Originality/value – This study has been successful in focusing on some aspects of growth and behaviour enhancement in children.
Paper type Research paper
Short-term temperature variability in a tropical Andean city Manizales, Colombia
Authors: Zambrano Nájera Jeannette , Delgado Victor , Vélez Upegui Jorge Julian 
Published: September 2021

The climatic variability in the Tropical Andes area is high, both spatially and temporally, and its analysis must be carried out both in the short and long term depending on the available information. This type of spatial-temporal analysis provides tools for planning and environmental management in urban areas, given its high complexity. This investigation focuses on a diagnosis of the diurnal cycle and the analysis of the monthly temperature structure in 13 stations located in the city of Manizales, Caldas (Colombia). This applied research aims to understand the behavior of the temperature in a tropical Andes city in Colombia, where the spatial-temporal complexity of this variable improve the urban and hydrological planning strategies. Results correspond to what has been previously defined by other authors for the Andean zone: city temperature shows very stable patrons, yet important variations in temperature range across the city are appreciated during the day.
Analisis Faktor Risiko Kejadian HIV/AIDS Berbasis Perilaku Manusia Di Kabupaten Madiun Tahun 2018
Authors: Kartini Puri Ratna 
Published: September 2021

Background: HIV / AIDS is a behavior-based disease. The HIV epidemic is a serious problem and challenge to public health in the world both in developed and developing countries such as Indonesia. In Asia, the factors driving the HIV / AIDS epidemic are three high-risk behaviors, namely unprotected commercial sex, sharing syringes in drug users and sex between unprotected men. This study is an observational-analytic study that aims to analyze the influence of human behavior factors included in the practice of free sex, alcohol consumption practices, drug use practices, attitudes and practices of weak religious teachings against the incidence of HIV / AIDS in Madiun Regency.Methods: The research design used was case control, with a purposive sampling technique. Data was taken through interviews to respondents using questionnaires and analyzed using logistic regression tests. This research was conducted in the working area of the Madiun District AIDS Eradication Commission (KPAD) for 6 months, starting from January to June 2018. The case group in this study were 20 HIV-AIDS sufferers selected and the control group was family / neighboring of the HIV / AIDS sufferers who does not suffer from HIV / AIDS as many as 20 people.Result: The results of this study show that the practice of injecting drug use (p> 0.005 which is 1,000) and alcoholic consumption practices (p> 0.005 which is 0.355) is not a risk factor for HIV / AIDS in Madiun Regency. Whereas the risky sex practices and weak religious teaching practices are the risk factors for HIV / AIDS in Madiun Regency which value of p is 0.017 and 0.021.Conclusion : Thus there is a need for counseling efforts about safe sex and to increase faith and piety in order to reduce the risk of transmission of HIV / AIDS in Madiun regency.
Design and modeling of multi-operation bit-manipulator logic circuit using lithium niobate waveguides
Authors: Kumari Anu , Srivastava Vivek Kumar , Pal Amrindra , Sharma Sandeep 
Published: September 2021

Abstract
In this work, a high-performance multioperation bit-manipulator is presented. The presented electro-optical design can perform several bit-manipulations such as bidirectional bit-shifting, bit-rotation, multiply-by-2 and divide-by-2, and sequence designing operation. The technique relies on the electrooptic principle in lithium niobate. Lithium niobate-based waveguides have been used to design Mach–Zehnder interferometer, which is the fundamental optical switching element of the whole model. Extinction ratio, contrast ratio, and insertion loss values computed for the simulated results are 29.16 dB, 29.48 dB, and 0.77 dB, respectively.
Management of perinatal HPP during critical illness/ECMO
Authors: Krishnan Neetu , Dunbar Nancy 
Published: September 2021

Abstract

Objectives
With the advent of asfotase alfa, the enzyme replacement therapy (ERT) approved for hypophosphatasia (HPP), health care providers need to navigate management of ERT during critical illness.

Case presentation
We present the case of a young girl, treated with ERT for severe perinatal HPP, who had cardiorespiratory arrest in the setting of influenza A. Her life-saving treatment involving extra corporeal membrane oxygenation (ECMO) required a two-week interruption of ERT leading to persistent hypercalcemia and hyperphosphatemia. A three year old female presented with respiratory distress and blood tinged secretions. She was influenza A positive with bilateral opacities on chest X-ray (CXR). Worsening respiratory distress and bradycardic arrest required intubation, CPR and venoarterial ECMO cannulation. She remained on ECMO for 10 days with anticoagulation restrictions requiring her thrice-weekly subcutaneous ERT to be held. Hypercalcemia (12.3 mg/dL) and hyperphosphatemia (7.6 mg/dL) developed two weeks after restarting ERT and resolved six weeks later.

Conclusions
We highlight that the obligatory cessation of ERT while on ECMO led to the loss of functional TNSALP with a profound decrease in bone mineralization leading to excess circulating calcium and phosphorus. In cases where it is necessary to interrupt ERT, we advise close monitoring of calcium and phosphorous levels.
An interpersonal framework of international ecological discourse
Authors: Wei Ruby Rong 
Published: September 2021

Abstract
This paper explores an interpersonal framework for international ecological discourse analysis using systemic functional linguistics. It shows that the sub-categories of the functional interpersonal framework need to be extended in terms of delicacy along the ecological cline to construe the ecological features in the context under investigation. The extension can be achieved through an integration of the following ecological parameters into a functional framework: a system of international ecological factors, a system of international ecological environment, and the international ecosophy “多元和谐, 交互共生” (duoyuan hexie, jiaohu gongsheng, ‘diversity and harmony, interaction and co-existence’). This integration builds an “ecological” interpersonal framework for international ecological discourse analysis, which is composed of an “ecological” Mood system, an “ecological” Modality system, and an “ecological” Appraisal system. The construction of an ecological interpersonal framework is accompanied by specific case analysis.
Montgomery identity and Ostrowski-type inequalities via quantum calculus
Authors: Sitthiwirattham Thanin , Ali Muhammad Aamir , Budak Huseyin , Abbas Mujahid , Chasreechai Saowaluck 
Published: September 2021

Abstract
In this paper, we prove a quantum version of Montgomery identity and prove some new Ostrowski-type inequalities for convex functions in the setting of quantum calculus. Moreover, we discuss several special cases of newly established inequalities and obtain different new and existing inequalities in the field of integral inequalities.
Expression and function analysis of CRABP2 and FABP5, and their ratio in esophageal squamous cell carcinoma
Authors: Li Mengyan , Li Chao , Lu Pengfei , Wang Bo , Gao Yongmei , Liu Wengying , Shi Yan , Ma Yuqing 
Published: September 2021

AbstractObjectiveThe purpose of this study was to explore the effect of CRABP2 and FABP5, and their ratio on prognosis in esophageal squamous cell carcinoma.MethodsThe expression data of CRABP2 in esophageal cancer in TCGA and GEO were collected by the public database GEPIA. The expression levels of CRABP2 and FABP5 were examined using immunohistochemistry. The relationship between the two proteins and related clinicopathological parameters were analyzed byχ2test. Survival analysis was used to investigate the effect of CRABP2 and FABP5, and their ratio on prognosis.ResultsCompared with normal esophageal mucosal epithelium, there was lower CRABP2 gene mRNA in the esophageal cancer tissue, and the difference was statistically significant (p< 0.01). For the expression level, no significant difference was observed in patients with stages I–IV in esophageal cancer. Immunohistochemistry showed that CRABP2 and FABP5 were both highly expressed in normal esophageal squamous epithelial cells at 100 and 94.1%, while lower in ESCC (75.6 and 58.7%). There was a significant difference in the expression between cancer and adjacent tissues (p< 0.001). No inherent relationship was manifested between the CRABP2 expression and the clinical parameters of the ESCC. The expression of FABP5 was related to lymph node metastasis (p= 0.032), the depth of invasion (p= 0.041), and the AJCC stage (p= 0.013). The ratio of CRABP2 and FABP5 was related to ethnicity (p= 0.001), nerve invasion (p= 0.031), and postoperative treatment (p= 0.038). CRABP2 is positively associated with FABP5 (r= 0.156,p= 0.041) and the ratio (r= 0.334,p= 0.000), while there was a negative correlation between FABP5 and the ratio (r= −0.269,p= 0.000). Patients with CRABP2-positive expression had a significantly longer overall survival than patients with CRABP2-negative expression (p= 0.025).ConclusionCRABP2 as a suppressor factor is expected to be a potential prognosis marker for esophageal squamous cell carcinoma.
The crystal structure of bis(2-acetyl-5-methoxyphenyl)carbonate 1.5 hydrate, C19H18O7
Authors: Liu Juan , Chen Sai , Li Honglei 
Published: September 2021

Abstract
C19H18O7, orthorhombic, P21212 (no. 18), a = 12.467(3) Å, b = 39.168(8) Å, c = 7.6005(16) Å, V = 3711.4(14) Å3, Z = 4, R

gt
(F) = 0.0440, wR

ref
(F
2) = 0.1054, T = 296.15 K.
Interaction of cationic surfactant with acid yellow dye in absence/presence of organic and inorganic additives: conductivity and dye solubilization methods
Authors: Haque Md. Ariful , Mahbub Shamim , Rahman Mohammad Majibur , Hoque Md. Anamul , Kumar Dileep , Alsaiari Norah Salem , Wabaidur Saikh M. , Alsubaie Fehaid Mohammed 
Published: September 2021

Abstract
In the present study, the conductometric and dye-solubilization techniques have been utilized to investigate the interaction between an anionic dye (acid yellow 23 [AY]) and a cationic surfactant (cetyltrimethylammonium bromide [CTAB]) in presence of organic (ethanol)/inorganic (NaCl) additives. From the conductometric method, two critical micelle concentrations (cmc) were found for AY + CTAB mixture in an aqueous system and the cmc values were found to undergo a change with the variation of AY concentrations. The cmc values of AY + CTAB systems were observed higher in the alcoholic medium, while the same was found to be lower in the NaCl solutions. The change in cmc of AY + CTAB systems shows an U-like curve with an increase of temperature. The negative free energy of micellization (

Δ

G
m
o

${\Delta}{G}_{m}^{o}$

) for the AY + CTAB systems has indicated a spontaneous micelle formation in all of the cases studied. The enthalpy (

Δ

H
m
o

${\Delta}{H}_{m}^{o}$

), as well as the entropy of micellization (

Δ

S
m
o

${\Delta}{S}_{m}^{o}$

) for the AY + CTAB systems, were assessed and discussed with proper reasoning. Additionally, the enthalpy-entropy compensation parameters were also investigated and illustrated. The solubility of AY and C
D was observed to rise linearly with an increase in the concentration of CTAB/NaCl solution. The solubilization capacity (χ) of AY, the molar partition coefficient (K
M) amongst the micellar and the aqueous phase, and free energy of solubilization (

Δ

G
S
o

${\Delta}{G}_{S}^{o}$

) were evaluated and discussed in detail. The former parameters undergo an increase with an increase of NaCl concentrations.