bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTSD in parents of children with severe diseases: a systematic review to face Covid-19 impact
Authors: Corsi Martina , Orsini Alessandro , Pedrinelli Virginia , Santangelo Andrea , Bertelloni Carlo Antonio , Carli Niccolò , Buselli Rodolfo , Peroni Diego , Striano Pasquale , Dell’Osso Liliana , Carmassi Claudia 
Published: January 2021

Abstract
Context
The literature agrees on the impact of post-traumatic stress symptoms in parents of seriously ill children but there is less clarity about the real extent and gender differences of this psychopathological risk. The recent Covid-19 outbreak highlighted new burdens for researchers on Post Traumatic Stress Disorder (PTSD) and clear evidence-based knowledge on this issue is timely needed.

Objective
In this review, we present a synthesis of the updated evidence on PTSD rates in parents of children with severe diseases.
We also aim to try to understand if research in this field has been refined over time with the long-term intent to better face the new challenges of Covid-19 in the paediatric field.

Data sources
The PubMed database was searched.

Study selection
Studies were included if they assessed PTSD in parents of children diagnosed with physical illnesses.

Data extraction
Of 240 studies, 4 were included.

Results
Analysis of the 4 studies revealed 2 studies with PTSD rates around 20% and in line with previous best-evidence. All 4 studies tried to provide more data on fathers, however, all the studies present the lack of a control group.

Limitations
The limited number of studies, which also differ widely in the methodology used.

Conclusions
Methodological errors evidenced in all the 4 studies limit their reliability, making the understanding of the paediatric caregiver’s concern regarding PTSD still difficult. More sound research is needed.
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity
Authors: Wu Xujia , Xiao Songhua , Zhang Maolei , Yang Lixuan , Zhong Jian , Li Bo , Li Fanying , Xia Xin , Li Xixi , Zhou Huangkai , Liu Dawei , Huang Nunu , Yang Xuesong , Xiao Feizhe , Zhang Nu 
Published: January 2021

Abstract
Background
Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), a key component of Hedgehog signaling, remains largely unknown.

Results
In this study, we describe a novel protein SMO-193a.a. that is essential for Hedgehog signaling activation in glioblastoma. Encoded by circular SMO (circ-SMO), SMO-193a.a. is required for sonic hedgehog (Shh) induced SMO activation, via interacting with SMO, enhancing SMO cholesterol modification, and releasing SMO from the inhibition of patched transmembrane receptors. Deprivation of SMO-193a.a. in brain cancer stem cells attenuates Hedgehog signaling intensity and suppresses self-renewal, proliferation in vitro, and tumorigenicity in vivo. Moreover, circ-SMO/SMO-193a.a. is positively regulated by FUS, a direct transcriptional target of Gli1. Shh/Gli1/FUS/SMO-193a.a. form a positive feedback loop to sustain Hedgehog signaling activation in glioblastoma. Clinically, SMO-193a.a. is more specifically expressed in glioblastoma than SMO and is relevant to Gli1 expression. Higher expression of SMO-193a.a. predicts worse overall survival of glioblastoma patients, indicating its prognostic value.

Conclusions
Our study reveals that SMO-193a.a., a novel protein encoded by circular SMO, is critical for Hedgehog signaling, drives glioblastoma tumorigenesis and is a novel target for glioblastoma treatment.
Analysis of the lipid extraction performance in a cascade process for Scenedesmus almeriensis biorefinery
Authors: Papachristou I. , Akaberi S. , Silve A. , Navarro-López E. , Wüstner R. , Leber K. , Nazarova N. , Müller G. , Frey W. 
Published: January 2021

Abstract
Background
Microalgae have attracted considerable interest due to their ability to produce a wide range of valuable compounds. Pulsed Electric Fields (PEF) has been demonstrated to effectively disrupt the microalgae cells and facilitate intracellular extraction. To increase the commercial viability of microalgae, the entire biomass should be exploited with different products extracted and valorized according to the biorefinery scheme. However, demonstrations of multiple component extraction in series are very limited in literature. This study aimed to develop an effective lipid extraction protocol from wet Scenedesmus almeriensis after PEF-treatment with 1.5 MJ·kgDW−1. A cascade process, i.e., the valorization of several products in row, was tested with firstly the collection of the released carbohydrates in the water fraction, then protein enzymatic hydrolysis and finally lipid extraction. Biomass processed with high pressure homogenization (HPH) on parallel, served as benchmark.

Results
Lipid extraction with ethanol:hexane (1:0.41 vol/vol) offered the highest yields from the different protocols tested. PEF-treatment promoted extraction with almost 70% of total lipids extracted against 43% from untreated biomass. An incubation step after PEF-treatment, further improved the yields, up to 83% of total lipids. Increasing the solvent volume by factor 2 offered no improvement. In comparison, extraction with two other systems utilizing only ethanol at room temperature or elevated at 60 °C were ineffective with less than 30% of total lipids extracted.
Regarding cascade extraction, carbohydrate release after PEF was detected albeit in low concentrations. PEF-treated samples displayed slightly better kinetics during the enzymatic protein hydrolysis compared to untreated or HPH-treated biomass. The yields from a subsequent lipid extraction were not affected after PEF but were significantly increased for untreated samples (66% of total lipids), while HPH displayed the lowest yields (~ 49% of total lipids).

Conclusions
PEF-treatment successfully promoted lipid extraction from S. almeriensis but only in combination with a polar:neutral co-solvent (ethanol:hexane). After enzymatic protein hydrolysis in cascade processing; however, untreated biomass displayed equal lipid yields due to the disruptive effect of the proteolytic enzymes. Therefore, the positive impact of PEF in this scheme is limited on the improved reaction kinetics exhibited during the enzymatic hydrolysis step.
Predictors of radiographic erosion and joint space narrowing progression in patients with early rheumatoid arthritis: a cohort study
Authors: Rydell Emil , Forslind Kristina , Nilsson Jan-Åke , Karlsson Magnus , Åkesson Kristina E. , Jacobsson Lennart T. H. , Turesson Carl 
Published: January 2021

Abstract
Background
Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors of these entities separately.

Methods
Consecutive early RA patients (symptom duration ≤12 months) from a defined area (Malmö, Sweden) recruited during 1995–2005 were investigated. Radiographs of hands and feet were scored by a trained reader according to the modified Sharp-van der Heijde score. Fat mass and lean mass distribution were measured at baseline using dual energy x-ray absorptiometry. Potential predictors of erosion and JSN progression from inclusion to the 5-year follow-up were evaluated.

Results
Two hundred and thirty-three patients were included. Radiographs at baseline and 5 years were available for 162 patients. The median (interquartile) progression of erosion and JSN scores were 4 (0–8) and 8 (1–16), respectively. Rheumatoid factor (RF) was a robust significant predictor of both erosion and JSN score progression. In adjusted analyses, anti-CCP antibodies predicted erosions while the erythrocyte sedimentation rate was predictive of both outcomes. Smoking and high baseline disease activity (DAS28 > 5.1) predicted progression of erosions. Baseline erosion score was associated with progression of both erosion and JSN progression, while baseline JSN score was predictive only of the progression of JSN. Overweight/obesity (BMI ≥ 25 kg/m2) was a significant negative predictor of JSN score progression (β = − 0.14, p = 0.018, adjusted for RF, age, baseline JSN score) also when additionally adjusting for ever smoking (p = 0.041). Among female patients, this effect was observed in those of estimated post-menopausal age (> 51 years), but not in younger women. The truncal to peripheral fat ratio was associated with less JSN score progression in women, but not in men.

Conclusions
Overweight RA patients had less JSN progression, independent of smoking status. This effect was seen in particular among older women (mainly post-menopausal), but not younger. Truncal fat was associated with less JSN progression in female patients. Smoking predicted erosion progression, and erosions may precede JSN. BMI and fat distribution may influence cartilage damage in early RA and might be related to hormonal factors.
Effectiveness of interventions to increase uptake and completion of treatment for diabetic retinopathy in low- and middle-income countries: a rapid review protocol
Authors: Bascaran Covadonga , Mwangi Nyawira , D’Esposito Fabrizio , Cleland Charles , Gordon Iris , Ulloa Juan Alberto Lopez , Maswadi Ranad , Mdala Shaffi , Ramke Jacqueline , Evans Jennifer R. , Burton Matthew 
Published: January 2021

Abstract
Background
Vision loss due to diabetic retinopathy can largely be prevented or delayed through treatment. Patients with vision-threatening diabetic retinopathy are typically offered laser or intravitreal injections which often require more than one treatment cycle. However, treatment is not always initiated, or it is not completed, resulting in poor visual outcomes. Interventions aimed at improving the uptake or completion of treatment for diabetic retinopathy can potentially help prevent or delay visual loss in people with diabetes.

Methods
We will search MEDLINE, Embase, Global Health and Cochrane Register of Studies for studies reporting interventions to improve the uptake of treatment for diabetic retinopathy (DR) and/or diabetic macular oedema (DMO), compared with usual care, in adults with diabetes. The review will include studies published in the last 20 years in the English language. We will include any study design that measured any of the following outcomes in relation to treatment uptake and completion for DR and/or DMO: (1) proportion of patients initiating treatment for DR and/or DMO among those to whom it is recommended, (2) proportion of patients completing treatment for DR and/or DMO among those to whom it is recommended, (3) proportion of patients completing treatment for DR and/or DMO among those initiating treatment and (4) number and proportion of DR and/or DMO rounds of treatment completed per patient, as dictated by the treatment protocol. For included studies, we will also report any measures of cost-effectiveness when available. Two reviewers will screen search results independently. Risk of bias assessment will be done by two reviewers, and data extraction will be done by one reviewer with verification of 10% of the papers by a second reviewer. The results will be synthesised narratively.

Discussion
This rapid review aims to identify and synthesise the peer-reviewed literature on the effectiveness of interventions to increase uptake and completion of treatment for DR and/or DMO in LMICs. The rapid review methodology was chosen in order to rapidly synthesise the available evidence to support programme implementers and policy-makers in designing evidence-based health programmes and public health policy and inform the allocation of resources.

Systematic review registration
OSF osf.io/h5wgr
Refinements of the integral Jensen’s inequality generated by finite or infinite permutations
Authors: Horváth László 
Published: January 2021

AbstractThere are a lot of papers dealing with applications of the so-called cyclic refinement of the discrete Jensen’s inequality. A significant generalization of the cyclic refinement, based on combinatorial considerations, has recently been discovered by the author. In the present paper we give the integral versions of these results. On the one hand, a new method to refine the integral Jensen’s inequality is developed. On the other hand, the result contains some recent refinements of the integral Jensen’s inequality as elementary cases. Finally some applications to the Fejér inequality (especially the Hermite–Hadamard inequality), quasi-arithmetic means, andf-divergences are presented.
Best approximation of κ-random operator inequalities in matrix MB-algebras
Authors: Madadi Masoumeh , O’Regan Donal , Rassias Themistocles M. , Saadati Reza 
Published: January 2021

AbstractWe introduce a class of stochastic matrix control functions and apply them to stabilize pseudo stochastic κ-random operator inequalities in matrix MB-algebras. We obtain an approximation for stochastic κ-random operator inequalities and calculate the maximum error of the estimate.
Antibiotic prescribing in inpatient and outpatient settings in Iran: a systematic review and meta-analysis study
Authors: Nabovati Ehsan , TaherZadeh Zhila , Eslami Saeid , Abu-Hanna Ameen , Abbasi Reza 
Published: January 2021

Abstract
Background
Antibiotic prescribing is common worldwide. There are several original studies about antibiotic prescribing in the healthcare setting of Iran reporting different levels of prescribing. The aim of this systematic review and meta-analysis was to determine the prevalence of antibiotic prescribing in both inpatient and outpatient settings in Iran, an example of a developing country.

Methods
To identify published studies on antibiotic prescribing, databases such as ISI, Scopus, PubMed, Google Scholar, and Electronic Persian were searched in Iran till January 2020. Eligible studies were those analyzing original data on the prescription and use of antibiotics in outpatient or inpatient settings in Iran. Moreover, all studies that used an intervention to improve antibiotic prescribing were included. The quality of the included studies was assessed using self-administered quality assessment criteria. The meta-analysis of prevalence of antibiotic prescribing was conducted based on the meta-analysis of observational studies in epidemiology guidelines. To calculate pooled rates, the random-effects model was used.

Results
A total of 54 studies (39 outpatients and 15 inpatients) were included in this study. The median of antibiotic prescribing in the outpatient and inpatient settings accounted for 45.25% and 68.2% of patients, respectively. The results of meta-analysis also showed that the antibiotic prescribing accounted for 45% of prescriptions in outpatient settings and 39.5%, 66%, and 75.3% of patients in all wards, pediatrics wards, and ICU wards of inpatient settings, respectively. The most commonly prescribed antibiotic classes in outpatient settings were penicillins, cephalosporins, and macrolides, while in inpatient settings, these were cephalosporins, penicillins, and carbapenems. There were seven studies using interventions to improve antibiotic prescribing pattern. It should be mentioned that intervention in a study had a statistically significant effect on improving antibiotic prescribing (p < .05).

Conclusion
Prevalence of antibiotic prescribing in Iran is high. Our findings highlight the need for urgent action to improve prescription practices. It seems that developing a national plan to improve antibiotic prescribing is necessary.
Application of three different coaching strategies through a virtual coach for people with emotional eating: a vignette study
Authors: Dol Aranka , Bode Christina , Velthuijsen Hugo , van Strien Tatjana , van Gemert-Pijnen Lisette 
Published: January 2021

Abstract
Background
Around 13% of the world’s population suffers from obesity. More than 40% of people with obesity display emotional eating behaviour (eating in response to negative emotions or distress). It is an alternate to more effective coping strategies for negative emotions. Our study explored the opportunities for helping adults with emotional overeating using a virtual coach, aiming to identify preferences for tailored coaching strategies applicable in a personal virtual coach environment. Three different coaching strategies were tested: a validating, a focus-on-change, and a dialectical one – the latter being a synthesis of the first two strategies.

Methods
A qualitative study used vignettes reflecting the two most relevant situations for people with emotional eating: 1. experiencing negative emotions, with ensuing food cravings; and 2. after losing control to emotional eating, with ensuing feelings of low self-esteem. Applied design: 2 situations × 3 coaching strategies. Participants: 71 adult women (Mage 44.4/years, range 19–70, SD = 12.86) with high scores on the DEBQ-emotional eating scale (Memo 3.65, range 1.69–4.92, SD = .69) with mean BMI 30.1 (range 18–46, SD = 6.53). They were recruited via dieticians’ practices, were randomly assigned to the conditions and asked how they would face and react to the presented coaching strategies. Data were transcribed and a thematic analysis was conducted.

Results
Qualitative results showed that participants valued both the validating coaching strategy and the focus-on-change strategy, but indicated that a combination of validation and focus-on-change provides both mental support and practical advice. Data showed that participants differed in their level of awareness of the role that emotions play in their overeating and the need for emotion-regulation skills.

Conclusion
The design of the virtual coach should be based on dialectical coaching strategies as preferred by participants with emotional eating behaviour. It should be tailored to the different stages of awareness of their emotions and individual emotion-regulation skills.
Biostimulant-induced drought tolerance in grapevine is associated with physiological and biochemical changes
Authors: Irani Hosein , ValizadehKaji Babak , Naeini Mohammad Reza 
Published: January 2021

Abstract
Background
In this research, the effects of exogenous application of certain biostimulants [amino acid (AA), humic acid (HA), fulvic acid (FA), and seaweed extract (SE)] on the fruit yield and quality, leaf mineral contents, and some critical physio-chemical characteristics of grapevine (Vitis vinifera L.) cv. ‘Yaghouti’ were investigated under well-watered (WW) and drought-stressed (DS) conditions.

Results
Drought stress caused a remarkable reduction in the weight of 20 berries and fruit yield, and meanwhile a marked increase in the titratable acidity (TA) and total soluble solid (TSS) content of fruits. Application of biostimulants, especially SE, enhanced the weight of 20 berries, fruit yield, and TSS content, and decreased TA in fruits of DS vines. Although drought stress had a negative effect on the chlorophyll content of grapevine, this effect was alleviated by the application of biostimulants, especially SE. Moreover, drought stress made the accumulation of abscisic acid (ABA), proline, total phenol, and soluble carbohydrates, the level of hydrogen peroxide (H2O2) and malondialdehyde (MDA), as well as the activity of guaiacol peroxidase (GPX) and catalase (CAT) enzymes increased in leaves. Application of biostimulants, especially SE, further increased the accumulation of ABA, proline, total phenol, and soluble carbohydrates and the activity of the antioxidant enzymes, but reduced the level of MDA and H2O2 in DS vines. Under drought stress conditions, concentrations of N, P, and K increased, and concentrations of Fe and Zn decreased; however, DS grapevines treated with biostimulants and especially SE accumulated a higher level of these mineral nutrients than CON vines.

Conclusion
In sum, as evidenced by the study results, biostimulants have a high potential for promoting fruit yield and quality of grapevine in drought-prone regions.
Patterns of infections and antimicrobial drugs’ prescribing among pregnant women in Saudi Arabia: a cross sectional study
Authors: Baraka Mohamed A. , AlLehaibi Lina Hussain , AlSuwaidan Hind Nasser , Alsulaiman Duaa , Islam Md. Ashraful , Alotaibi Badriyah Shadid , Alboghdadly Amany , Homoud Ali H. , Al-Ghamdi Fuad H. , Al Ghamdi Mastour S. , Babar Zaheer-Ud-Din 
Published: January 2021

AbstractBackgroundAntimicrobial agents are among the most commonly prescribed drugs in pregnancy due to the increased susceptibility to infections during pregnancy. Antimicrobials can contribute to different maternal complications. Therefore, it is important to study their patterns in prescription and utilization. The data regarding this issue is scarce in Saudi Arabia. Therefore, the aim of this study is to generate data on the antimicrobial agents that are most commonly prescribed during pregnancy as well as their indications and safety.MethodsThis is a retrospective study focusing on pregnant women with a known antimicrobial use at Johns Hopkins Aramco Healthcare (JHAH). The sample included 344 pregnant women with a total of 688 antimicrobial agents prescribed. Data was collected on the proportion of pregnant women who received antimicrobial agents and on the drug safety during pregnancy using the risk categorization system of the U.S. Food and Drug Administration (FDA).ResultsThe results showed that urinary tract infections (UTIs) were the most reported (59%) infectious diseases. Around 48% of pregnant women received antimicrobial medications at some point during pregnancy. The top two antimicrobial agents based on prescription frequency were B-lactams (44.6%) and azole anti-fungals (30%). The prescribed drugs in the study were found to be from classes B, C and D under the FDA risk classification system.ConclusionThe study revealed a high proportion of antimicrobials prescribed during pregnancy that might pose risks to mothers and their fetuses. Future multicenter studies are warranted to evaluate the rational prescription of antimicrobial medications during pregnancy.