bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Nine Apoptosis-Related Genes Signature Predicting Overall Survival for Kidney Renal Clear Cell Carcinoma and its Associations with Immune Infiltration
Authors: Wang Yi , Chen Yinhao , Zhu Bingye , Ma Limin , Xing Qianwei 
Published: March 2021

Background: This study was designed to establish a sensitive prognostic model based on apoptosis-related genes to predict overall survival (OS) in patients with clear cell renal cell carcinoma (ccRCC).Methods: Obtaining the expression of apoptosis-related genes and associated clinical parameters from online datasets (The Cancer Genome Atlas, TCGA), their biological function analyses were performed through differently expressed genes. By means of LASSO, unadjusted and adjusted Cox regression analyses, this predictive signature was constructed and validated by internal and external databases (both TCGA and ArrayExpress).Results: A total of nine apoptosis-related genes (SLC27A2, TNFAIP2, IFI44, CSF2, IL4, MDK, DOCK8, WNT5A, APP) were ultimately screened as associated hub genes and utilized to construct a prognosis model. Then our constructed riskScore model significantly passed the validation in both the internal and external datasets of OS (all p &lt; 0.05) and verified their expressions by qRT-PCR. Moreover, we conducted the Receiver Operating Characteristic (ROC), finding the area under the ROC curves (AUCs) were all above 0.70 which indicated that riskScore was a stable independent prognostic factor (p &lt; 0.05). Furthermore, prognostic nomograms were established to figure out the relationship between 1-, 3- and 5-year OS and individual parameters for ccRCC patients. Additionally, survival analyses indicated that our riskScore worked well in predicting OS in subgroups of age, gender, grade, stage, T, M, N0, White (all p &lt; 0.05), except for African, Asian and N1 (p &gt; 0.05). We also explored its association with immune infiltration and applied cMap database to seek out highly correlated small molecule drugs.Conclusion: Our study successfully constructed a prognostic model containing nine hub apoptosis-related genes for ccRCC, helping clinicians predict patients’ OS and making the prognostic assessment more standardized. Future prospective studies are required to validate our findings.
Robotic Versus Conventional Nipple-Sparing Mastectomy With Immediate Breast Reconstruction
Authors: Houvenaeghel Gilles , Barrou Julien , Jauffret Camille , Rua Sandrine , Sabiani Laura , Van Troy Aurore , Buttarelli Max , Blache Guillaume , Lambaudie Eric , Cohen Monique , Bannier Marie 
Published: March 2021

BackgroundSeveral studies reported the feasibility and safety of robotic-NSM (R-NSM). The aim of our prospective study was to compare R-NSM and conventional-NSM (C-NSM).MethodsWe analyzed patients who were operated on with and without robotic assistance (R-NSM or C-NSM) and who received immediate breast reconstruction (IBR) with implant or latissimus dorsi-flap (LDF). The main objective was complication rate and secondary aims were post-operative length of hospitalization (POLH), duration of surgery, and cost.ResultsWe analyzed 87 R-NSM and 142 C-NSM with implant-IBR in 50 and 135 patients, with LDF-IBR in 37 and 7 patients, respectively. Higher durations of surgery and costs were observed for R-NSM, without a difference in POLH and interval time to adjuvant therapy between R-NSM and C-NSM. In the multivariate analysis, R-NSM was not associated with a higher breast complication rate (OR=0.608) and significant factors were breast cup-size, LDF combined with implant-IBR, tobacco and inversed-T incision. Grade 2-3 breast complications rate were 13% for R-NSM and 17.3% for C-NSM, significantly higher for LDF combined with implant-IBR, areolar/radial incisions and BMI&gt;=30. A predictive score was calculated (AUC=0.754). In logistic regression, patient’s satisfaction between C-NSM and R-NSM were not significantly different, with unfavorable results for BMI &gt;=25 (OR=2.139), NSM for recurrence (OR=5.371) and primary breast cancer with radiotherapy (OR=4.533). A predictive score was calculated. In conclusion, our study confirms the comparable clinical outcome between C- NSM and R-NSM, in the price of longer surgery and higher cost for R-NSM. Predictive scores of breast complications and satisfaction were significantly associated with factors known in the pre-operative period.
ESRα Promoter Methylation May Modify the Association Between Lipid Metabolism and Type 2 Diabetes in Chinese Farmers
Authors: Zhou Guoyu , Liu Lihua , Li Xing , Hou Xiangbo , Wang Ling , Sun Renjie , Huang Hui , Li Zhiyuan , Li Wenjie , Wang Chongjian , Ba Yue 
Published: March 2021

Objective: This study is aimed to explore the potential association among the estrogen receptor alpha (ESRα) promoter methylation, lipid metabolism and the risk of type 2 diabetes mellitus (T2DM).Methods: A total of 1143 rural residents were recruited randomly from Henan Province, China. The circulating methylation levels in ESRα promoter region were determined by quantitative methylation-specific polymerase chain reaction. Serum high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC) and fasting plasma-glucose (FPG) were measured.Results: The ESRα promoter methylation levels were negatively associated with HDL-C levels whether gender stratification was performed (P &lt; 0.05) and positively correlated with LDL-C in men (P &lt; 0.05). Each unit standard deviation (SD) increment in TG was associated with a 43% increase (95% CI: 1.25, 1.64) in the risks of T2DM in all participants, a 36% increase (95% CI: 1.13, 1.64) in the risks of T2DM in men and a 49% increase (95% CI: 1.21, 1.83) in the risks of T2DM in women. Furthermore, each SD increment in HDL-C was associated with a reduction of 25% (OR = 0.75, 95% CI: 0.58, 0.97) in the risks of T2DM in men, and the risk of T2DM in men may be more susceptible to HDL-C than that in women (P for interaction &lt; 0.05). Additionally, we found that the risk of T2DM in participants with lower methylation levels (≤4.07%) were more susceptible to HDL-C (P for interaction &lt; 0.05).Conclusions: These findings suggested that lipid metabolism was associated with ESRα promoter methylation levels and the risk of T2DM. Besides, the levels of ESRα promoter methylation and gender can modify the association of HDL-C and T2DM.
An Improvement of the Lower Bound on the Minimum Number of ≤k-Edges
Authors: Rodrigo Javier , Merchán Susana , Magistrali Danilo , López Mariló 
Published: March 2021

In this paper, we improve the lower bound on the minimum number of ≤k-edges in sets of n points in general position in the plane when k is close to n2. As a consequence, we improve the current best lower bound of the rectilinear crossing number of the complete graph Kn for some values of n.
Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review
Authors: Bhate Ketaki , Lin Liang-Yu , Barbieri John S , Leyrat Clémence , Hopkins Susan , Stabler Richard , Shallcross Laura , Smeeth Liam , Francis Nick , Mathur Rohini , Langan Sinéad M , Sinnott Sarah-Jo 
Published: March 2021

BackgroundAntimicrobial resistance (AMR) is a global health priority. Acne vulgaris is a common skin condition for which antibiotic use ranges from a few months to years of daily exposure.AimTo systemically search for and synthesise evidence on the risk of treatment-resistant infections, and other evidence of AMR, following long-term oral antibiotic use for acne.Design & settingIn this systematic review, a literature search was carried out using the databases Embase, MEDLINE, Cochrane, and Web of Science. They were searched using MeSH, Emtree, or other relevant terms, and followed a pre-registered protocol.MethodSearch strategies were developed with a librarian and undertaken in July 2019. All searches date from database inception. The primary outcome was antibiotic treatment failure or infection caused by a resistant organism. Secondary outcomes included detection of resistant organisms without an infection, rate of infection, or changes to flora.ResultsA total of 6996 records were identified. Seventy-three full-text articles were shortlisted for full review, of which five were included. Two investigated rates of infection, and three resistance or changes to microbial flora. Three studies had 35 or fewer participants (range 20–118 496). Three studies had a serious or high risk of bias, one moderate, and one a low risk of bias. Weak evidence was found for an association between antibiotic use for acne and subsequent increased rates of upper respiratory tract infections and pharyngitis.ConclusionThere is a lack of high quality evidence on the relationship between oral antibiotics for acne treatment and subsequent AMR sequelae. This needs to be urgently addressed with rigorously conducted studies.
Progress of Self Help Group-Bank Linkage Programme in India
Authors: Muthu N 
Published: March 2021

In this paper an attempt has been made to analyse the progress of SHG-Bank linkage programme in India during the period between 2007-2008 and 2019-2020. The progress of SHG-Bank linkage programme has been analyzed in terms growth of savings of SHGs with banks and growth of bank loans disbursed to SHGs. For this purpose the data required for the study were collected from the official publication of National Bank for Agricultural and Rural Development (NABARD), different published reports, journals and existing available literature. This study employed simple statistical tools such as percentage analysis and averages to analyze the data. The result of the study shows that there is significant raise in the amount of savings of SHGs with banking sector and amount of loans disbursed to SHGs, During this study period. However the agency-wise analyses of savings of SHGs and loans disbursed to SHGs show that the Commercial banks lead in getting savings of SHGs and loans disbursed to them followed by Regional Rural Banks and Co-operative banks. Not with standing the remarkable progress, geographically there has been skewed development of SHG-Bank linkage programme in India. There is wide regional disparity in the spread of SHGs, savings of SHGs with banks and loans disbursed to SHGs under this programme. The outreach of this programme is spectacular in Southern region while North, West and Eastern regions are lagging behind. In view of the large outreach, predominant position and the possible benefits to the poor, it is very important to see the benefits of this programme to reach across all sections of the society and regions. So far the SHG movement is India is mostly South-Centric and it is yet to take off the real sense in other regions of India.
Analytical indicators of observation.The year-by-year lethality of patients at each year
Authors: Merabishvili Vakhtang 
Published: March 2021

Year-by-year lethality – the lethality of patients with malignant tumors in each year of observation - an indicator that determines the risk of death of patients, depending on the localization of tumors.
Lethality of patients in the first year of follow-up includes posthumously registered patients with malignant tumors, and is the inverse criterion to the indicator of one-year observed survival. In subsequent years, the calculation of year-by-year lethality is carried out without posthumously registered patients. It is important to note that the calculation of partial mortality rates is carried out only for the number of patients who died from malignant tumors. It is necessary to exclude patients who have dropped out of observation at each year of observation. Calculation of the year-by-year lethality indicator is possible only if there are at least 100 primary registered patients.
In February 2019, we created the database of the Population cancer registry. The North-Western Federal district (NWFD)of the Russian Federation, which includes more than 1 million patients (1211891 patients with posthumously registered patients and 1071112 cases without posthumously registered patients). Only reliable data was selected for development, the number of which was almost 10% less. In 2020, the database of the Population cancer registry of the NWFD of the Russian Federation increased by 73054 cases. We used the updated database in this study. The observation period is from 1994 to 2020. The year-by-year lethality study was conducted in total for all ICD-10 categories for the C00-96 neoplasm class.
DB analysis showed that in the NWFD of the Russian Federation, the proportion of posthumously registered patients decreased from 1995 to 2018 (both sexes) from 21.1 to 8.1%.
For 1995 – 1999, 2000 – 2004, the year-by-year lethality was calculated for 10 years of observation, the period 2005-2009 covered the year-by-year lethality for 7 years of observation, 2005-2009 for 5 years. We have considered the specifics of year-by-year lethality separately for men and women, for people from 0-34, 35-59, 60 years and older.
We pay special attention to year-by-year lethality for patients with localized (stage I and II of the disease) and widespread process (stage III and IV, including patients without the specified stage of the disease, which, as a rule, by the level of survival belong to stage III and IV of the disease).
The Development of Civic-Mindedness in College Students
Authors: Плотникова Е.Ю. 
Published: March 2021

В статье рассмотрена актуальная проблема формирования гражданской позиции
у обучающихся гетерогенных групп в колледже. Представлены результаты опытно-экспериментальной работы по формированию гражданской позиции обучающихся гетерогенных групп в колледже. Сформулированы цель и гипотеза; описаны критерии и показатели сформированности гражданской позиции обучающихся в возрасте 15–19 лет (когнитивный, мотивационно-ценностный и деятельностный); организация и этапы экспериментальной работы. Методики диагностики гражданской позиции (бланковый тест М. Рокича «Ценностные ориентации», опросник А. Мехрабиена, Н. Эпштейна «Способность к эмпатии», анкета Е. Н. Титовой, Т. А. Мирошиной) позволили выявить доминирующие ценностные ориентации, уровень эмпатии обучающихся колледжа и степень осознания ими сущности гражданской позиции.
Описана теоретическая модель формирования гражданской позиции у обучающихся гетерогенных групп колледжа, на основе которой создана авторская программа «Моя страна», стимулирующая развитие этой позиции.
Дана краткая характеристика программы, предполагающей взаимодействие педагогов с разновозрастной группой первокурсников 15–19 лет с учетом индивидуально-личностных особенностей обучающихся и социальных условий их воспитания, в частности социального благополучия/неблагополучия семей.
Описаны результаты проверки авторской программы, экспериментально подтверждающие ее эффективность.
The article treats an urgent issue associated with the development of civic-mindedness in college students in heterogeneous classrooms. The article accounts for the aim and the hypothesis of the research, describes the criteria that can be used to assess the levels of civic-mindedness development in 15-19-year olds (cognitive, motivational, value-based, and activity-based), focuses on the organization and stages of experimental work.
The methods of assessing civic-mindedness (the Rokeach Value Survey, the Mehrabian Questionnaire, the Epstein Questionnaire Measure of Emotional Empathy, the Titova and Miroshina Questionnaire) enable the author to single out dominant value orientations, the level of emotional empathy in college students, the level of their civic-mindedness.
The author of the article describes a theoretical model of civic-mindedness development in college students in heterogeneous classrooms and presents her own course “My Country” aimed at the development of civic-mindedness in students.
The article describes the My Country course, which presupposes teachers’ interaction with 15-19-year old first-year students. It is expected that teachers should take into account their students’ individual characteristics and personality traits, their social backgrounds, the level of their family wellbeing.
The article describes the results of the course elaborated by the author, and provides experimental evidence that the course is efficient.
First Observed Interaction of the Circumstellar Envelope of an S-star with the Environment of Sgr A*
Authors: Peißker Florian , Ali Basel , Zajaček Michal , Eckart Andreas , Hosseini S. Elaheh , Karas Vladimír , Clénet Yann , Sabha Nadeen B. , Labadie Lucas , Subroweit Matthias 
Published: March 2021

Abstract
Several publications highlight the importance of the observations of bow shocks to learn more about the surrounding interstellar medium and radiation field. We revisit the most prominent dusty and gaseous bow shock source, X7, close to the supermassive black hole, Sgr A*, using multiwavelength analysis. For the purpose of this study, we use Spectrograph for Integral Field Observations in the Near Infrared (SINFONI) (H+K-band) and NACO L′- and M′-band) data sets between 2002 and 2018 with additional COMIC/ADONIS+RASOIR (L′-band)
7

7

COME-ON-PLUS Infrared Camera/Adaptive Optics Near Infrared System + Renouveau de l’Analyseur de Surface d’Onde InfraRouge
data of 1999. By analyzing the line maps of SINFONI, we identify a velocity of ∼200 km s−1 from the tip to the tail. Furthermore, a combination of the multiwavelength data of NACO and SINFONI in the H-, K-, L′-, and M′-bands results in a two-component blackbody fit that implies that X7 is a dust-enshrouded stellar object. The observed ongoing elongation and orientation of X7 in the Brγ line maps and the NACO L′-band continuum indicate a wind arising at the position of Sgr A* or at the IRS16 complex. Observations after 2010 show that the dust and the gas shell seems to be decoupled in the projection from its stellar source S50. The data also implies that the tail of X7 thermally heats up due to the presence of S50. The gas emission at the tip is excited because of the related forward scattering (Mie scattering), which will continue to influence the shape of X7 in the near future. In addition, we find excited [Fe iii] lines, which together with the recently analyzed dusty sources and the Brγ-bar underline the uniqueness of this source.
Spectroscopic and Photometric Redshift Estimation by Neural Networks for the China Space Station Optical Survey (CSS-OS)
Authors: Zhou Xingchen , Gong Yan , Meng Xian-Min , Zhang Xin , Cao Ye , Chen Xuelei , Amaro Valeria , Fan Zuhui , Fu Liping 
Published: March 2021

Abstract
The estimation of spectroscopic and photometric redshifts (spec-z and photo-z) is crucial for future cosmological surveys. It can directly affect several powerful measurements of the universe, such as weak lensing and galaxy clustering. In this work, we explore the accuracies of spec-z and photo-z that can be obtained by the China Space Station Optical Surveys, which is a next-generation space survey, using a neural network. The one-dimensional Convolutional Neural Networks and Multi-Layer Perceptron (MLP, the simplest form of an artificial neural network) are employed to derive spec-z and photo-z, respectively. The mock spectral and photometric data used for training and testing the networks are generated based on the COSMOS catalog. The networks have been trained with noisy data by creating Gaussian random realizations to reduce the statistical effects, resulting in a similar redshift accuracy for data with both high and low signal-to-noise ratios. The probability distribution functions of the predicted redshifts are also derived via Gaussian random realizations of the testing data, and then the best-fit redshifts and 1σ errors also can be obtained. We find that our networks can provide excellent redshift estimates with accuracies of ∼0.001 and 0.01 on spec-z and photo-z, respectively. Compared to existing photo-z codes, our MLP has a similar accuracy but is more efficient in the training process. The fractions of catastrophic redshifts or outliers can be dramatically suppressed compared to the ordinary template-fitting method. This indicates that the neural network method is feasible and powerful for spec-z and photo-z estimations in future cosmological surveys.
CRAFTS for Fast Radio Bursts: Extending the Dispersion–Fluence Relation with New FRBs Detected by FAST
Authors: Niu Chen-Hui , Li Di , Luo Rui , Wang Wei-Yang , Yao Jumei , Zhang Bing , Zhu Wei-Wei , Wang Pei , Ye Haoyang , Zhang Yong-Kun , Niu Jia-rui , Tang Ning-yu , Duan Ran , Krco Marko , Dai Shi , Feng Yi , Miao Chenchen , Pan Zhichen , Qian Lei , Xue Mengyao , Yuan Mao , Yue Youling , Zhang Lei , Zhang Xinxin 
Published: March 2021

Abstract
We report three new FRBs discovered by the Five-hundred-meter Aperture Spherical radio Telescope (FAST), namely FRB 181017.J0036+11, FRB 181118, and FRB 181130, through the Commensal Radio Astronomy FAST Survey (CRAFTS). Together with FRB 181123, which was reported earlier, all four FAST-discovered FRBs share the same characteristics of low fluence (≤0.2 Jy ms) and high dispersion measure (DM, >1000 pc cm−3), consistent with the anticorrelation between DM and fluence of the entire FRB population. FRB 181118 and FRB 181130 exhibit band-limited features. FRB 181130 is prominently scattered (τ

s
≃ 8 ms) at 1.25 GHz. FRB 181017.J0036+11 has full-bandwidth emission with a fluence of 0.042 Jy ms, which is one of the faintest FRB sources detected so far. CRAFTS has started to build a new sample of FRBs that fills the region for more distant and fainter FRBs in the fluence–DME diagram, previously out of reach of other surveys. The implied all-sky event rate of FRBs is

1.24

−
0.90

+
1.94

×

10

5

sky−1 day−1 at the 95% confidence interval above 0.0146 Jy ms. We also demonstrate here that the probability density function of CRAFTS FRB detections is sensitive to the assumed intrinsic FRB luminosity function and cosmological evolution, which may be further constrained with more discoveries.