bluuebunny/crossref_metadata_2025_split huggingface dataset:
A daily, 250 m and real-time gross primary productivity product (2000–present) covering the contiguous United States
Authors: Jiang Chongya , Guan Kaiyu , Wu Genghong , Peng Bin , Wang Sheng 
Published: February 2021

Abstract. Gross primary productivity (GPP) quantifies the amount of
carbon dioxide (CO2) fixed by plants through photosynthesis. Although
as a key quantity of terrestrial ecosystems, there is a lack of
high-spatial-and-temporal-resolution, real-time and observation-based GPP
products. To address this critical gap, here we leverage a state-of-the-art
vegetation index, near-infrared reflectance of vegetation (NIRV), along
with accurate photosynthetically active radiation (PAR), to produce a
SatelLite Only Photosynthesis Estimation (SLOPE) GPP product for the
contiguous United States (CONUS). Compared to existing GPP products, the
proposed SLOPE product is advanced in its spatial resolution (250 m versus
>500 m), temporal resolution (daily versus 8 d), instantaneity
(latency of 1 d versus >2 weeks) and quantitative
uncertainty (on a per-pixel and daily basis versus no uncertainty
information available). These characteristics are achieved because of
several technical innovations employed in this study: (1) SLOPE couples
machine learning models with MODIS atmosphere and land products to
accurately estimate PAR. (2) SLOPE couples highly efficient and pragmatic
gap-filling and filtering algorithms with surface reflectance acquired by
both Terra and Aqua MODIS satellites to derive a soil-adjusted NIRV
(SANIRV) dataset. (3) SLOPE couples a temporal pattern recognition
approach with a long-term Cropland Data Layer (CDL) product to predict dynamic
C4 crop fraction. Through developing a parsimonious model with only two
slope parameters, the proposed SLOPE product explains 85 % of the spatial
and temporal variations in GPP acquired from 49 AmeriFlux eddy-covariance
sites (324 site years), with a root-mean-square error (RMSE) of
1.63 gC m−2 d−1. The median R2 over C3 and C4 crop sites reaches 0.87
and 0.94, respectively, indicating great potentials for monitoring crops, in
particular bioenergy crops, at the field level. With such a satisfactory
performance and its distinct characteristics in spatiotemporal resolution
and instantaneity, the proposed SLOPE GPP product is promising for
biological and environmental research, carbon cycle research, and a broad
range of real-time applications at the regional scale. The archived dataset
is available at https://doi.org/10.3334/ORNLDAAC/1786 (download
page: https://daac.ornl.gov/daacdata/cms/SLOPE_GPP_CONUS/data/, last access: 20 January 2021) (Jiang and Guan, 2020), and
the real-time dataset is available upon request.
Associations between Monocyte Cytokine Profiles and Co-Morbid Conditions in Autism Spectrum Disorders
Authors: Jyonouchi Harumi , Geng Lee 
Published: February 2021

Autism spectrum disorder (ASD) is a behaviorally defined syndrome with frequent co-morbidities. Evidence indicate a role of innate immunity in ASD pathogenesis. This study addressed whether innate immune abnormalities are associated with ASD co-morbid conditions and/or other clinical co-variables when assessed as changes in monocyte cytokine profiles. This study included 109 ASD (median 11.5 year) and 26 non-ASD subjects (median 11.4 year). Monocyte cytokine profiles were evaluated in association with age/ethnicity, ASD severity, medications, and co-morbidities present in >15% of ASD subjects [gastrointestinal (GI) symptoms, epilepsy, allergic rhinitis, specific antibody deficiency (SAD), and fluctuating behavioral symptoms resembling pediatric acute-onset neuropsychiatric syndrome (PANS)]. ASD severity did not affect frequency of co-morbid conditions. GI symptoms, epilepsy, SAD, and PANS like symptoms revealed associations with changes in production of tumor necrosis factor-α (TNF-α)/soluble TNF-receptor II (sTNFRII), interleukin-1ß (IL-1ß)/IL-6/IL-10, and IL-6, respectively, mostly independent of other co-variables. ASD severity was associated with changes in multiple cytokines but frequently affected by other clinical co-variables. Our findings revealed associations between specific monocyte cytokine profiles and certain co-morbid conditions in ASD subjects, independent of other clinical co-variables. Our findings will aid in assessing treatment options for ASD co-morbidities and their effects on ASD behavioral symptoms.
Academics against Gender Studies
Authors: Näser-Lather Marion 
Published: February 2021

In Germany, knowledge production by gender researchers has been under attack not only from male rights activists, Christian fundamentalists and right-wing parties and movements, but also from scientists in various fi elds. Based on a discourse analysis of their publications (2009-2017) and a media reception analysis, this essay analyses arguments used by ‘gender’-critical scientists and the socio-political backgrounds to where they position themselves. I show that their arguments do not belong to scientifi c discourse, but can be interpreted as a form of science populism which lends ‘scientific’ authority to the formation of authoritarian, anti-feminist discourses that aims to reify ‘secure’ knowledge about ‘gender’. Accordingly, ‘gender-critical’ scientists are read mainly by non-scientific publics, including right-wing and Christian fundamentalist media and actors. As I will show, the phenomenon of scientists taking action against ‘gender’ can be situated in historical antifeminism, as well as contemporary discourses on the crisis-like character of the dynamics regarding gender knowledge and societal conditions.
Histomonose em pavão (Pavo cristatus)
Authors: Nery dos Reis Gabriela , Smaha de Jesus Lima Joana Cristina , Das Neves Nogueira Thais Lara , Dos Santos Toledo Roberta , Togni Monique 
Published: February 2021

O objetivo desse trabalho foi descrever um caso de histomonose em pavão (Pavo cristatus), como também os métodos de diagnóstico e as alterações macroscópicas e histopatológicas características desta doença. Um pavão criado extensivamente em uma propriedade, e em contato com outras aves, foi encaminhado morto ao Laboratório de Patologia Animal do Centro Universitário Integrado, em Campo Mourão, PR. Durante a necropsia, verificou-se que o ceco apresentava serosa com áreas hemorrágicas multifocais e que o fígado exibia leve aumento com áreas levemente pálidas multifocais. Fezes e fragmentos dos órgãos foram coletados e encaminhados para a análise. No exame coproparasitológico notou-se a presença de ovo de Heterakis gallinarum, hospedeiro paratênico do Histomonas meleagridis. No intestino foram identificadas lesões em forma de placas circulares firmes, com bordas brancacentas e enegrecidas; no fígado, áreas levemente pálidas. Na análise histopatológica determinou-se hepatite com necrose hepática, necrose e ulceração do ceco, sendo estas lesões características de histomonose.
Numerıcal Examınatıon of Heat Exchanger Shape Effects on Thermal Effıcıency in Aır to Aır Plate Type Heat Recovery Unıt’s
Authors: ATMACA Mustafa , SAVAT Hasan 
Published: February 2021

Dünyada enerji ihtiyacı ve tüketimi giderek artmaktadır. Bu sebep ile enerji tüketimini azaltmak ve enerjiyi daha verimli kullanılmak her geçen gün daha önem kazanmaktadır. Bu sebeple enerji verimliliği gerek ekonomik gerekse doğanın korunması açısından büyük önem taşımaktadır.
Isı geri kazanım cihazı, havalandırılma ihtiyacı olan, dış ortamla farklı sıcaklıktaki tüm mahallerde (ev, ofis, sinema, AVM, Konferans salonu vb.) enerji tasarrufu sağlamak (enerji tüketimini azaltmak) için kullanılabilen bir sistemdir. Bu cihaz dışarı atılacak hava ile iç ortama alınacak hava arasında ısı transferi yaparak, ısıtma ve soğutma işlemlerinden ciddi oranda tasarruf ve enerji kazancı sağlayabilmektedir.
Bu cihazın en yaygın kullanılan türü plakalı ısı değiştiricili olanıdır. Bu sistemde ısı transferi dışarı atılan kirli hava ile içeri alınan temiz hava arasında 2 havanın karışmasına izin verilmeden yapılmaktadır. Bu çalışmada cihazın, ısıl verimliliğinin artırılması amaçlanmıştır. Bunun için kullanılan ısı değiştiricisinin geometrisi değiştirilerek ısı transferi artırılmak istenmiştir.
Bunun için mevcut olan model sanal ortamda (bilgisayar ortamında) oluşturularak, ANSYS-Fluent programı vasıtasıyla bilgisayar benzetimleri (simülasyonları) yapılmıştır. Sonrasında bilgisayar ortamında farklı geometrilere sahip yeni modeller oluşturulmuş ve aynı metot kullanılarak bu modeller üzerinde benzetimler (simülasyonlar) yapılmıştır. Yeni modellerin mevcut model ile ısıl verimleri karşılaştırılmıştır.
A risk score model with five long non-coding RNAs for predicting prognosis in gastric cancer: an integrated analysis combining TCGA and GEO datasets
Authors: Wu Yiguo , Deng Junping , Lai Shuhui , You Yujuan , Wu Jing 
Published: February 2021

Background
Gastric cancer (GC) is one of the most common carcinomas of the digestive tract, and the prognosis for these patients may be poor. There is evidence that some long non-coding RNAs(lncRNAs) can predict the prognosis of patients with GC. However, few lncRNA signatures have been used to predict prognosis. Herein, we aimed to construct a risk score model based on the expression of five lncRNAs to predict the prognosis of patients with GC and provide new potential therapeutic targets.

Methods
We performed differentially expressed and survival analyses to identify differentially expressed survival-ralated lncRNAs by using GC patient expression profile data from The Cancer Genome Atlas (TCGA) database. We then established a formula including five lncRNAs to predict the prognosis of patients with GC. In addition, to verify the prognostic value of this risk score model, two independent Gene Expression Omnibus (GEO) datasets, GSE62254 (N = 300) and GSE15459 (N = 200), were employed as validation groups.

Results
Based on the characteristics of five lncRNAs, patients with GC were divided into high or low risk subgroups. The prognostic value of the risk score model with five lncRNAs was confirmed in both TCGA and the two independent GEO datasets. Furthermore, stratification analysis results showed that this model had an independent prognostic value in patients with stage II–IV GC. We constructed a nomogram model combining clinical factors and the five lncRNAs to increase the accuracy of prognostic prediction. Enrichment analysis based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) suggested that the five lncRNAs are associated with multiple cancer occurrence and progression-related pathways.

Conclusion
The risk score model including five lncRNAs can predict the prognosis of patients with GC, especially those with stage II-IV, and may provide potential therapeutic targets in future.
Effect of vitamin D supplementation in patients with chronic hepatitis C after direct-acting antiviral treatment: a randomized, double-blind, placebo-controlled trial
Authors: Sriphoosanaphan Supachaya , Thanapirom Kessarin , Kerr Stephen J. , Suksawatamnuay Sirinporn , Thaimai Panarat , Sittisomwong Sukanya , Sonsiri Kanokwan , Srisoonthorn Nunthiya , Teeratorn Nicha , Tanpowpong Natthaporn , Chaopathomkul Bundit , Treeprasertsuk Sombat , Poovorawan Yong , Komolmit Piyawat 
Published: February 2021

Background
Replacement of vitamin D (VD) among patients with chronic hepatitis C (CHC) before viral eradication has demonstrated a protective effect on serum markers associated with hepatic fibrogenesis. We therefore hypothesized that VD may facilitate further fibrosis amelioration following curative treatment with direct-acting antivirals (DAA).

Methods
This study was a randomized, double-blind, placebo-controlled trial conducted between February 2018 and August 2018. Patients with CHC and VD deficiency were randomized in a 1:1 ratio to either receive ergicalciferol or placebo over 6 weeks. Biochemical analysis indicators, including 25-hydroxyvitamin D (25(OH)D), fibrogenic markers [(transforming growth factor beta 1 (TGF-β1) and tissue inhibitors of matrix metalloproteinases 1 (TIMP-1)], and fibrolytic markers [matrix metalloproteinase 9 (MMP-9) and amino terminal type III procollagen peptide (P3NP)], were assessed at baseline and at 6 weeks. Serum 25(OH)D was analyzed by a chemiluminescence immunoassay. Serum hepatic fibrogenesis markers were measured using a quantitative sandwich enzyme-linked immunosorbent assay.

Results
Seventy-five patients with CHC and VD deficiency were randomly assigned to VD (n = 37) and placebo (n = 38) groups. At the end of the study, the mean serum 25(OH)D level had risen to a normal level in the VD group, but was still deficient in the placebo group (41.8 ± 9.1 vs. 18.1 ± 4.6 ng/mL, p < 0.001). Upon restoration of the VD level, there were no significant mean differences in the change from baseline for TGF-β1 (−0.6 ng/mL (95% confidence interval (95% CI) [−2.8–1.7]), p = 0.63), TIMP-1 (−5.5 ng/mL (95% CI [−26.4 –15.3]), p = 0.60), MMP-9 (122.9 ng/mL (95% CI [−69.0 –314.8]), p = 0.21), and P3NP (−0.1 ng/mL (95% CI [−2.4 –2.2]), p = 0.92) between the VD and placebo groups.

Conclusion
Short-term VD supplementation after DAA treatment in patients with CHC does not improve serum fibrogenesis markers and may not expedite the residual liver fibrosis healing process. Future studies are warranted to evaluate the long-term effect of VD supplementation on hepatic fibrosis regression.
Role of CaMK II α in the Injury of Dorsal Root Ganglion Neurons Induced by Ropivacaine Hydrochloride in the Dorsal Root Ganglion of Rats
Authors: Zhaoxia Wu , Meixin Chen , Yiqun Li , Shuxuan Yang , Xianjie Wen 
Published: February 2021

Objective: To investigate whether CaMKⅡα participates in the dorsal root ganglion neurotoxicity induced by ropivacaine hydrochloride.
Methods: DRG neurons were isolated from 1-day-old SD rats and cultured in vitro. pAd-shRNA-CaMKⅡα-DRG cells were constructed by RNA interference technique to inhibit the expression of CaMKⅡα. The experiment was divided into six groups: DRG group (DRG group), vector DRG group (vector group), pAd-shRNA- CaMKIIα-DRG group (pAd-shRNA group), DRG + ropivacaine group (DRG + R group), vector DRG + ropivacaine group (vector + R group), pAd-shRNA-CaMKII α - DRG + ropivacaine group (pAd-shRNA + R group), and the last three groups were treated with 3 mM ropivacaine hydrochloride for 4 hours. MTT assay was used to detect cell viability, flow cytometry was used to detect cell apoptosis rate, laser confocal microscopy was used to detect intracellular calcium level, and real-time PCR was used to detect the mRNA expression of CaMKⅡα, Cav3.2 and Cav3.3.
Results: The cell viability of DRG+R group, vector+R group and pAd-shRNA+R group decreased significantly after 3 mM ropivacaine hydrochloride treatment for 4 h. Compared with DRG+R group, the cell viability of pAd-shRNA+R group was significantly higher. After 3 mM ropivacaine hydrochloride treatment for 4 h, the apoptosis rate of DRG + R group, vector + R group and pAd-shRNA + R group increased significantly. Compared with DRG+R group, the apoptosis rate in pAd shRNA+R group was significantly lower. After 3 mM ropivacaine hydrochloride treatment for 4 h, the intracellular calcium levels in DRG + R group, vector + R group and pAd-shRNA + R group were significantly increased, and the intracellular calcium levels in pAd-shRNA + R group were significantly lower than those in DRG + R group. The mRNA expressions of CaMKⅡα, Cav3.2 and Cav3.3 were significantly decreased in pAd- shRNA group. The mRNA expressions of CaMK Ⅱ α, Cav3.2 and Cav3.3 were up-regulated in DRG + R group, vector + R group and pAd-shRNA + R group after 3 mm ropivacaine treatment for 4 h. The mRNA expressions of CaMKⅡα, Cav3.2 and Cav3.3 in pAd-shRNA + R group were significantly lower than those in DRG + R group.
Conclusion: Inhibition of CaMKⅡα expression can down regulate the expression of Cav3.2 and Cav3.3 mRNA, increase cell viability of DRG neurons, reduce the apoptosis rate, and improve the dorsal root ganglion neurotoxicity induced by ropivacaine hydrochloride.
VLVS: A Knime Based Virtual Library Generation and Screening Workflow
Authors: Akgün Ismail Hakki 
Published: February 2021

Objective: Tocreate an easy-to-use structure-based screening workflow using KNIME and open source software to prepare and screen virtual libraries in order to discover novel bioactive or drug molecules.
Materials and Methods: In the preparation of the workflow we mentioned in the article KNIME version 4, AutoDock Vina, Pymol were used. KNIME plugins used in this study are RDKit KNIME Integration, ChemAxon/Infocom Marvin Extensions Feature, KNIME Python Integration, Lhasa Metabolism Feature, KNIME Ploty and KNIME JavaScript View. We have used Python3 and libraries in the python scripts through Anaconda installation.
Results: A workflow that can work with a single click after making required adjustments which uses docking as structure-based screening method was created and tested.
Conclusion: With the workflow we have created, it will be possible for researchers especially those who are working in the field of computer-aided drug design/development to create personalized molecule libraries, perform virtual screening, reporting the results in a short time with the least effort.
O uso do território no Brasil na perspectiva de uma revolução, mas que revolução? A necessidade de uma pedagogia política
Authors: Moura de Castilho Cláudio Jorge 
Published: February 2021

<p><br />O uso do território no Brasil tem acontecido visando tornar o seu espaço mais fluido à realização dos interesses do capital, criando e agravando as desigualdades e injustiças sociais. O objetivo do artigo é analisar o processo de uso do território na perspectiva de uma revolução calcada nas condicionantes histórico-geográficas brasileiras atuais. O método utilizado é o materialismo histórico-dialético, o qual teve suporte de revisão bibliográfica, observação de campo e escuta de pessoas das classes dominadas e oprimidas. A conclusão geral é de que uma revolução é um processo muito mais complexo do que se tem pensado e buscado executar a partir da academia.</p><p> </p>
Os princípios do comunismo em Engels (1847): apontamentos teórico-metodológicos para além do manifesto comunista
Authors: Sabará Raquel 
Published: February 2021

O objetivo do artigo é trazer a relevância do texto, Princípios do Comunismo, de autoria de Engels, na formulação do Manifesto Comunista e seus apontamentos teórico-metodológicos para o além do Manifesto. O texto segue assim organizado:<em> </em>Alguns antecedentes históricos do texto Princípios do Comunismo e do Manifesto Comunista<em>; </em>Por que o Manifesto Comunista não poderia ser chamado de socialista em 1848<em>; </em>Princípios do Comunismo: apontamentos para além do Manifesto Comunista<em>; </em>A negação de Engels acerca da paternidade das ideias fundamentais contidas no Manifesto Comunista.
Em que medida Engels contribui para a crítica da política no Manifesto?
Authors: Filho Júlio César Villela da Motta 
Published: February 2021

<span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">No presente artigo, pretendemos traçar qual a participação de Engels para a crítica da política presente no </span></span><span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">Manifesto do Partido comunista. </span></span><span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">Tendo em vista que o texto foi escrito tanto por Marx como por Engels, tem-se que para se aproximar da contribuição deste, necessário retomar, principalmente, o texto </span></span><span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">Princípios básicos do comunismo</span></span><span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">. Afinal, este foi escrito somente por Engels. Teria ele trazido a crítica da política da mesma forma como é abordada no </span></span><span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">Manifesto</span></span><span class="TextRun BCX8 SCXW154636565" lang="PT-BR" xml:lang="PT-BR" data-contrast="auto"><span class="NormalTextRun BCX8 SCXW154636565">? </span></span>
Diálogos circenses: entre escolas e suas práticas
Authors: Da Silva Rafael Resende Marques 
Published: February 2021

<p>A participação na oficina de palhaço no CNAC com Cédrik Paga em 2012 constituiu uma parte importante da pesquisa dentro da tese de doutorado, pois foi uma experiência enriquecedora e ajudou a responder às questões levantadas. Foi um material dentre outros objetos de estudo que permitiu uma interação qualitativa e ativa com a prática e a teoria do palhaço atualmente. O encontro com artistas, espetáculos e a participação de cursos foram instrumentos encontrados para experimentar o jogo do palhaço percebido por outros referenciais estéticos, pedagógicos e teóricos. Isto estimulou uma nova compreensão do fenômeno do palhaço além de fortalecer a ideia de que há uma necessidade de investimento público no circo como uma política de transformação da arte e da sociedade dentro de um país. </p>
A dança expandida de Lia Rodrigues: uma experiência artística e política na favela Maré
Authors: Kiffer Ana , Pavlova Adriana 
Published: February 2021

<span>Este artigo apresenta a trajetória da coreógrafa Lia Rodrigues (1956), mostrando como a artista sempre buscou </span><span>alargar suas possibilidades de agir no mundo, para além da criação coreográfica, tornando-se porta-voz da classe da dança no Rio de Janeiro nos anos 1990, criadora do Festival Panorama e um nome de projeção internacional. O estudo mostra nascimento de sua companhia, seguido da transferência do grupo para a residência na favela da Maré, na Zona Norte do Rio, em 2004, num projeto coreopolítico (Lepecki, 2012) que se estende até hoje, que mexeu com a sua dança mas também com a favela. E elenca todas as criações nos 30 anos da Lia Rodrigues Companhia de Danças, mostrando suas influências e reflexões dentro e fora da cena.</span>
Resenha do livro: Contabilidade Geral - Uma Abordagem Interativa. Carvalho, M. S.; Guimarães, G. O. M.; Cruz, C. F. São Paulo, SP: Atlas, 2019, 296 páginas, ISBN: 9788597019469
Authors: Oliveira José Renato Sena 
Published: February 2021

<p><span><span>Esta resenha tem o objetivo de apresentar uma síntese das principais ideias discutidas no livro Contabilidade Geral - Uma Abordagem Interativa, dos autores Márcia da Silva Carvalho, Guilherme Otávio Monteiro Guimarães e Cláudia Ferreira da Cruz, </span></span>lançado no ano de 2019, pela Editora Atlas.</p>