bluuebunny/crossref_metadata_2025_split huggingface dataset:
“LCAT Deficiency: a Systematic Review With the Clinical and Genetic Description of Mexican Kindred”
Authors: Mehta Roopa , Elías-López Daniel , Martagon Alexandro J. , Pérez-Méndez Oscar A , Sánchez Maria Luisa Ordóñez , Segura Yayoi , Tusié-Luna Maria Teresa , Aguilar-Salinas Carlos A. 
Published: April 2021

Abstract
Background: LCAT deficiency is characterized by two distinct phenotypes, familial LCAT deficiency (FLD) and Fish Eye disease (FED). In this study the results of the first systematic review evaluating the ethnic distribution of LCAT deficiency are shown, with particular emphasis on Latin America with discussion of three Mexican-Mestizo probands. Methods:A systematic review was conducted following the PRISMA Statement in Pubmed and SciELO. Articles which described subjects with LCAT deficiency syndromes and an assessment of the ethnic group to which the subject pertained, were considered for analysis. Results:The systematic review revealed 215 cases (154 FLD, 41 FED and 20 unclassified) pertaining to 33 ethnic/racial groups. There was no association between genetic alteration and ethnicity. The mean age of diagnosis was 42 ± 16.5 years, with FED identified later than FLD (55 ± 13.8 vs. 41 ± 14.7 years respectively). The prevalence of premature coronary heart disease was significantly greater in FED vs. FLD. In Latin America, 48 cases of LCAT deficiency have been published from six countries (Argentina (1 unclassified), Brazil (38 FLD), Chile (1 FLD), Columbia (1 FLD), Ecuador (1 FLD) and Mexico (4 FLD, 1 FED and 1 unclassified). Of the Mexican probands, one showed a novel LCAT mutation. Conclusion: The systematic review shows that LCAT deficiency syndromes are clinically and genetically heterogeneous. No association was confirmed between ethnicity and LCAT mutation. There was a significantly greater risk of premature coronary artery disease in FED compared to FLD. In FLD, the emphasis should be in preventing both cardiovascular disease and the progression of renal disease, while in FED, cardiovascular risk management should be the priority. The LCAT mutations discussed in this article are the only ones reported in the Mexican- Amerindian population.
Developing Patient Safety Standards for Quality Improvement in the NICUs: A Mixed-Methods Protocol
Authors: Shahkolahi Zahra , Irajpour Alireza , Jafari-Mianaei Soheila , Heidarzadeh Mohammad 
Published: April 2021

Abstract
Background

Neonatal intensive care unit is one of the accident-prone environments in the health care system. A range of structural and process factors threaten hospitalized infant safety in this unit. These factors are prevented by identifying safety needs and taking the right actions. In this regard, some countries in the world have developed standards. Developing standards based on current knowledge, available resources, and context that provide care, determine patient injury prevention requirements. Likewise, it can be a source for national development and application of guidelines, protocol, and laws. This study aims to develop patient safety standards in the Neonatal intensive care units of the Islamic Republic of Iran.
Methods

This mixed methods study will apply the Exploration, Preparation, Implementation, Sustainment framework to develop patient safety standards. The first three phases are the focus of this study. Due to investigating the long-term effects, it doesn't consider Phase 4(Sustainment). In each of these phases, a set of activities takes place. Designing Phase 1 (Exploration) is based on the World health organization model to develop standards. Determining the validity and applicability of developing standards will be done in Phase2 (preparation) and Phase 3 (implementation), respectively.
Discussion

Patient safety standards from this study are developed based on valid evidence and a comprehensive theoretical view. Additionally, considering parents' roles and the interdisciplinary experts' views in the neonatal intensive care unit. In this regard, determining the minimum requirements to maintain patient safety and developing evidence-based practice will be improved efficiency and effectiveness and contributed to equitable and higher quality health care delivery. The application of developing standards will be improving patient safety and quality of health care in the neonatal intensive care units of Iran.
Ultrasound-Guided Quadratus Lumborum Block as A Postoperative Analgesia for Total Abdominal Hysterectomy: A Case Report
Authors: Mohamed Haytham El Sayed , Najar Fadheela Al , Awad Mohamed Nasr , Hassan Faten M 
Published: April 2021

Abstract
Background and aim: Total Abdominal Hysterectomy is a major invasive abdominal surgery which is accompanied with severe postoperative pain. Multimodal analgesia techniques can provide efficient analgesics coverage with minimal side effects, Quadratus Lumborum Block is an abdominal wall block which gives a good analgesic effect for abdominal surgery with lower pain score and less opioids requirements.Case presentation: A 67 years old female was scheduled to undergo total abdominal hysterectomy surgery, she had comorbidities; morbid obesity, bronchial asthma, obstructive sleep apnea, and hypothyroidism. We performed General Anesthesia and by the end of surgery, a Quadratus Lumborum Block was done ultrasound-guided technique.Conclusion: We successfully performed Quadratus Lumborum Block bilaterally which was able to provide a sufficient analgesic effect for Total Abdominal Hysterectomy surgery, giving our patient the opportunity of early ambulation and avoiding opioids side effects especially the respiratory adverse effect.
The effect of intravenous ketamine and pethidine on postoperative shivering in surgical patients under general anesthesia in Tikur anbessa specialized hospital, Addis Ababa, Ethiopia: A prospective observational cohort study
Authors: Ganamo Geresu Gebeyehu , Girma Betelihem 
Published: April 2021

Abstract
Background

Postanesthesia shivering is one of the potential complications of anesthesia which may increase patient morbidity. Various methods have been employed to control postoperative shivering. This study assessed the effectiveness of prophylactic low-dose intravenous ketamine and pethidine for postoperative shivering after general anesthesia.
Methods and materials:

This prospective cohort study recruited 76 ASA I and II patients aged 18–65 years old and underwent elective surgery under general anesthesia. The patients were grouped based on either ketamine 0.5mg/kg or pethidine 0.5 mg/kg having been administered by the anaesthetist in charge as a prophylaxis for postoperative shivering 20 minutes before completion of the surgery. The incidence and severity of postoperative shivering were compared between the two groups every 10 minutes until one hour postoperatively. The side effects of the study drugs were also compared between the two groups in the recovery room. Categorical data were analyzed with the Chi-Square test. Parametric and nonparametric data between the groups were analyzed using independent samples t-test and Mann-Whitney U test, respectively. A p-value of < 0.05 was considered statistically significant.
Results

The incidence of shivering between the ketamine and pethidine groups was 11(28.2%) and 14(35.9%), respectively (p = 0.467). The severity of shivering was not significantly different between the two groups (p = 0.893). The occurrence of nausea and vomiting and sedation attributed to the drugs was significantly less in the ketamine group (p < 0.05). PACU stay duration and occurrence of hallucinations among the groups were comparable. (p > 0.05)
Conclusion and Recommendation:

This study revealed administering low-dose IV ketamine (0.5mg/kg) 20 minutes before completion of surgery reduced postoperative shivering as nearly equally as pethidine. The study also showed clinically better outcomes in favor of ketamine since it was associated with fewer side effects. Thus, we recommend low-dose IV ketamine 20 minutes before completion of surgery under general anesthesia to prevent postoperative shivering.
Simple efficient bounds for arcsine and arctangent functions
Authors: Bagul Yogesh J. , Dhaigude Ramkrishna M. 
Published: April 2021

Abstract
The aim of this paper is to present new, simple and sufficiently sharp bounds for arcsine and arctangent functions. Some of the bounds are computationally efficient while others are efficient to approximate the integrals Int_{a}^{b} (arcsin x)/x dx and Int_{a}^{b} (arctan x)/x dx. As a matter of interest, several other sharp and generalized inequalities for (arcsin x)/x and (arctan x)/x are also established which are efficient to give some known and other trigonometric inequalities
Viral Molecular Testing of Cerebrospinal Fluid in Adults with Suspected Central Nervous System Infection in an Italian University Hospital Laboratory: A Retrospective Study on 1462 Consecutive Patients
Authors: Basso Monica , Zago Daniela , Pozzetto Irene , Del Vecchio Claudia , Franchin Elisa , Dal Bello Federico , Pagni Silvana , . Maria , Biasolo Angela , Manganelli Riccardo , Palù Giorgio , Parisi Saverio Giuseppe 
Published: April 2021

Background:Generally, about half of the patients with central nervous system infections cases remain unexplained. Therefore, we aimed to describe which viruses were detected in unselected patients with a suspected central nervous system infection and the first diagnostic workflow in a university hospital laboratory.Methods:A comprehensive virus testing in cerebrospinal fluid with an in-house real-time PCR method was employed. Determining how many and which viruses to test was at the full discretion of the treating physician.Results:1462 patients were evaluated from 2011 to 2017 and 9 898 viral PCRs were made: 176 subjects (12%) had a positive result. There was great heterogeneity in the frequency of patients tested for each virus, ranging from 97.9% (1431 out of 1462) for herpes simplex virus (HSV) to 1.9% (28 out of 1462) for Parvovirus B19, positive in 1 patient. Enterovirus (EV) was the leading virus detected: the frequency was higher with respect to HSV (5.2% vs 2.4%, p=0.0004), varicella-zoster virus (VZV)(5.2% vs 2.9%, p=0.0052), human herpesvirus-6 (5.2% vs 1.7%, p=0.0014) and human herpesvirus-7 (HHV-7)(5.2% vs 2.5%, p=0.0406). Both VZV (83.5%) and HSV (97.9%) were tested significantly more than EV (68.7%, p<0.0001) and HHV-7 (24.1%, p<0.0001): the latter had a positivity comparable to HSV and it was detected in younger patients (median age 29 years), as for EV (median age 35 years). There was no difference found in the age of positive subjects with respect to negative ones for the other viruses tested.Conclusion:EV was the fifth virus frequently included in the diagnostic workflow but the most frequently detected, mostly in subjects aged less 40, as HHV-7 was. Testing these two viruses in all younger patients could reduce the number of unknown etiology.
Ensino remoto: espaço de conexões em tempo de pandemia
Authors: Nogueira Janaina 
Published: April 2021

Apresentar os principais desafios encontrados em 2020 durante o ensino remoto não é uma tarefa simples, uma vez que ainda estamos inseridos nesse contexto diferente da sociedade mundial. Pensar em resultados é algo prematuro. Conseguimos solucionar situações imediatas, mas não alcançamos o modelo ideal, pois com o passar dos dias fomos apenas nos organizando conforme as necessidades. Contudo, iniciamos pesquisas que nos permitiram modificar as práticas pedagógicas. Nesse cenário, fomos “obrigados” a conhecer ferramentas digitais que há tempos já faziam parte do cotidiano dos alunos, mas estavam em processo de inserção nas atividades de aula. Sair da zona de conforto e reformular as aulas em propostas inovadoras e eficientes tem sido um processo desafiador, mas precisamos nos conectar. Trabalhar com ferramentas digitais, como os aplicativos Padlet e Kahoot, são exemplos positivos de práticas que favorecem a interação no ensino remoto. Assim, todo trabalho desenvolvido deve-se também ao apoio das equipes técnico-pedagógica das instituições de ensino às quais presto serviço, principalmente aos meus professores do curso de Mestrado do Programa de Mestrado Profissional em Letras (PROFLETRAS), os quais me apresentaram a diversas práticas inovadoras de ensino e aprendizagem.
Examples of financing innovative projects
Authors: Wodzyńska Joanna , Czyżewski Rafał 
Published: April 2021

This article was written in order to characterize the innovative activity of enterprises in terms of its financing sources. Obtaining sufficient fundsis a basic requirement for undertaking any investment activ- ity and it largely determines the further investment process and related decisions. An analysis of the available sources of financing indicates the interdependence between the innovation’s subject area and the structure of its financing. The functioning of two selected companies dealing with the implementation of innovative products will serve as an illustration of both the theoretical and practical aspects of financing innovative projects. Design and methodology The paper hypothesizes that the financing of modern innovations requires flexible conditions and high level of capital,as verified by literature review and analysis of innovative products and companies. The article consists of three parts. The first defines the concept of innovation and characterizes individual types of innovation: technological, organizational and social. Also discussed are the characteristic features of the phenomenon of innovation, the conditions shaping itand the impact it has on economic growth. The second part is a review of existing sources of capital and methods of raising it through market and public instruments. Also discussed are the conditions for the use of individual instruments, depend- ing on the stage of enterprise development, as well as their potential advantages and limitations from the entrepreneur’s point of view. The third part analyzes innovative products and companies responsible for their creation and devel- opment: the self-driving vehicle created by the American company Tesla Inc. and a thermographic tester for oncological diagnostics created by the Polish company BRASTER. Findings and implications Innovation belongs to the developing field of economy and economics. Statistical and econometric studies prove that, due to the significant risk level, innovation needs to be stimulated. Its development has a positive impact both on GDP growth and living conditions. However, in order to keep up with the technological frontier, it is necessary to under take appropriate actions serving to reduce the technological gap. This is why financing innovation is a complex process, requiring a flexible approach. And there is a considerable variety of financial instruments dedicated to innovations offered by market entities and by state institutions. This theoretical work is illustrated with examples of companies implementing technologically sophisticated products. Tesla Inc. finances work on the self-driving vehicle by increasing operational obligations, issuing debt securities, additional capital contributions and even the sale of CO2 emission rights. On the other hand, BRASTER SA, while working on introducing the oncological tester on the market, accumulated capital as a result of large issues of shares and taking out bank loans, which indicates that the company is just learning investment processes.
Tradycja placów zabaw w Polsce i Europie
Authors: Ostrowska-Tryzno Anna , Nałęcz Hanna , Pawlikowska-Piechotka Anna 
Published: April 2021

W większości miast europejskich aż do XIX w. nie widziano potrzeby przeznaczenia dla dzieci specjalnych terenów do zabawy i wypoczynku. Od czasów antycznych zarówno w ogrodach prywatnych, jak i na terenach publicznych (wokół placów miejskich, świątyń) dzieci mogły bawić się swobodnie. W okresie nowożytnym potrzeba zapewnienia dzieciom i młodzieży odpowiednich warunków do aktywnego wypoczynku, traktowanego zarówno jako codzienna potrzeba wysiłku fizycznego, jak i sposób zagospodarowania świątecznego czasu wolnego w gronie rodziny i rówieśników – jest oczywista od niecałych 200 lat. Badacze przedmiotu nie są zgodni, co do dokładnej daty, jaką można przyjąć dla najstarszego placu zabaw. Najczęściej wskazywane są kolejne dekady XIX w.: w Europie – w Anglii rok 1859, w Niemczech 1860, a w krajach pozaeuropejskich – w USA 1887. Współczesne place zabaw, z jakimi mamy do czynienia na osiedlach naszych miast, znacząco już odbiegły zarówno programowo jak i funkcjonalnie od historycznych, pierwszych placów zabaw. Niemniej chyba warto przypomnieć te tradycje, ponieważ, pomimo niesprzyjających warunków, zarówno w okresie zaborów, w okresie II RP (1918– 1939), jak i trudnych powojennych latach odbudowy ze zniszczeń wojennych – polscy architekci i urbaniści, pedagodzy i wychowawcy, lekarze i działacze społeczni przywiązywali dużą wagę do zapewnienia dzieciom odpowiednio urządzonych terenów otwartych do wypoczynku i zabawy. Były to znaczące inicjatywy, nieustępujące osiągnięciom innych krajów europejskich, tworzące tradycję i dorobek, z którego mamy prawo być dumni.
Planowany rozwój energetycznych sieci przesyłowych w województwie mazowieckim
Authors: Gadomska Urszula , Gochnio Beata , Polak Elżbieta 
Published: April 2021

Artykuł przedstawia zbiorcze zestawienie zamierzeń inwestycyjnych, dotyczących energetycznych sieci przesyłowych planowanych w województwie mazowieckim, które zostały określone w różnych dokumentach, obowiązujących na koniec 2018 r. Budowa i przebudowa linii elektroenergetycznych najwyższych napięć oraz gazociągów wysokiego ciśnienia z infrastrukturą towarzyszącą to inwestycje rządowe, realizowane przez przedsiębiorstwa energetyczne, funkcjonujące jako spółki skarbu państwa. Tylko część z planowanych przedsięwzięć (inwestycje ustalone w dokumentach przyjętych przez Sejm lub organy rządu) obligatoryjnie ujęta jest w planie zagospodarowania przestrzennego województwa. W ostatnich latach realizacja większości planowanych przesyłowych sieci energetycznych przebiega według procedur określonych w dwóch tzw. specustawach energetycznych: przesyłowej i gazowej. Zgodnie z ich zapisami, w sprawach związanych z wydaniem decyzji o ustaleniu lokalizacji inwestycji oraz o pozwoleniu na budowę, nie mają zastosowania przepisy o planowaniu i zagospodarowaniu przestrzennym. Oznacza to możliwość realizacji zamierzeń nieujętych w dokumentach planistycznych – zarówno poziomu regionalnego, jak i gminnego. W związku z tym, że inwestycje energetyczne budzą wielkie protesty społeczne, zasadnym było opracowanie w tym zakresie kompleksowej informacji, która może zostać wykorzystana przez samorządy gminne w procesach negocjacji z przedsiębiorstwami energetycznymi oraz konsultacji z mieszkańcami i organizacjami pozarządowymi.
Lactancia a temprana edad: experiencias de madres adolescentes mayas en Yucatán
Authors: Aké Canul Didier Francisco , Balam Gómez Maricela , Pool Góngora Roberth Amílcar , Cohuo Cob Sheila Mariela , Uicab Pool Gloria De los Ángeles 
Published: April 2021

<p><strong>Introducción:</strong> En México, la lactancia materna exclusiva en menores de seis meses descendió entre el 2006 y 2012, de 22.3% a 14.5%, con mayor decadencia en el área rural. <strong>Metodología:</strong> Estudio cualitativo, bajo el enfoque de fenomenología descriptiva, con 9 madres adolescentes, empleando entrevistas a profundidad, observación no participante y diarios de campo; el objetivo fue analizar la lactancia a temprana edad, mediante las experiencias de madres adolescentes mayas en Yucatán. <strong>Hallazgos:</strong> Para las adolescentes, la lactancia tiene beneficios afectivos, previene el cáncer de mama, ayuda al crecimiento y desarrollo del bebé; la estética no fue afectada, refiriendo algunas sentir vergüenza al lactar en público; lactaron entre tres meses a dos años, abandonando por baja producción de leche, rechazo del bebé y lesiones del seno. Los cuidados son no salir al aire fresco, alimentarse sin condimentos ni picantes y beber abundantes líquidos como bebidas de maíz, caldos y agua; la mayoría inició la ablactación al cumplir sus bebés 6 meses; los alimentos para ablactar los eligen por practicidad, economía y mercadotecnia; usaron leche de fórmula, cereal, leguminosas y productos industrializados. <strong>Conclusión:</strong> Las madres adolescentes no están preparadas para tantos cambios, pero no les impidió lactar asumiendo esta práctica positivamente. La transición en las prácticas de las personas mayores a las adolescentes es con apoyo de conocimientos del personal de salud, saberes y construcciones sociales de mujeres cercanas, así como decisión propia.</p>
Cómics para el aprendizaje de la espectroscopia infrarroja
Authors: Castillo-Granada Alberta Lourdes , Ríos-Calderón Oscar Saúl , Soto-Páez Rodrigo , Benítez-Escamilla Teresa , Contreras Cruz David Atahualpa 
Published: April 2021

<p>En este trabajo se diseñó un material didáctico -cómic- como apoyo en el proceso de aprendizaje de la espectroscopia en el infrarrojo, para alumnos de las licenciaturas en Química Farmacéutica Biológica, Ingeniería Química y Biología. En los cómics se abordan de manera concreta los fundamentos teóricos acerca de lo que es la espectroscopia, la radiación infrarroja y cómo ésta última interactúa con las moléculas orgánicas; además de los principios básicos que permitieron a los estudiantes iniciar la interpretación de un espectro en el infrarrojo. Mediante un cuestionario de evaluación aplicado a 118 alumnos que leyeron los cómics, seguido de un análisis estadístico de los datos, se determinó que el material didáctico presentado influyó significativamente de manera positiva en el proceso de aprendizaje de los alumnos.</p>
“Mientras los generales duermen”
Authors: Ramírez Casas Ulises 
Published: April 2021

Durante el conflicto bélico entre México y los Estados Unidos, los habitantes de Sierra Gorda emprendieron un fuerte rechazo al llamado hecho por el gobierno mexicano para enrolarse en los cuerpos del ejército que combatirían a las tropas norteamericanas en el norte de México. A partir de documentación obtenida en el archivo estatal de Guanajuato, el presente artículo analiza los motivos de la oposición a la guerra entre los serragordanos y la manera peculiar como concibieron a los norteamericanos: no como enemigos, sino potenciales aliados frente al gobierno y las autoridades militares mexicanas que habían causado múltiples agravios entre las poblaciones, desde la anulación de gobiernos hasta la extracción de hombres de sus poblaciones de origen para conducirlos a una muerte segura en batalla.
Integrated Inventory Model for Single Vendor Multi-Buyer with a Single Item by Considering Warehouse and Capital Constraint
Authors: Agustiandi Agustiandi , Aritonang Yoon Mac Kinley , Rikardo Cherish 
Published: April 2021

Integrated inventory management coordinates all party's replenishment policies to provide optimal benefits. Many models have been developed, but none of them have considered capital and warehouse constraints comprehensively. It may cause the model which cannot be applied, since it has exceeded the capacity. This study developed an integrated inventory model that consisted of one vendor, multi-buyer, and one type of item. The main objective was to minimize the joint total expected cost by considering warehouse, capital, and service level constraint. The optimal formula was constructed by using the Lagrange multipliers method. The results showed that with an increment in holding cost, the vendor tends to reduce lot size to minimize joint total expected cost. It is vice versa to the increment in set up cost. An increment in buyer service level can increase lot size and reduce order frequency. The buyer capacity is essential to determine its capability to apply the optimal replenishment policy.