bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using an integrated knowledge translation or other research partnership approach in trainee-led research: a scoping review protocol
Authors: Cassidy Christine E , Beck Amy Jane , Conway Aislinn , Demery Varin Melissa , Laur Celia , Lewis Krystina B , Ramage Emily R , Nguyen Tram , Steinwender Sandy , Ormel Ilja , Stratton Lillian , Shin Hwayeon Danielle 
Published: May 2021

IntroductionCollaborative research approaches, such as co-production, co-design, engaged scholarship and integrated knowledge translation (IKT), aim to bridge the evidence to practice and policy gap. There are multiple benefits of collaborative research approaches, but studies report many challenges with establishing and maintaining research partnerships. Researchers often do not have the opportunity to learn how to build collaborative relationships, and most graduate students do not receive formal training in research partnerships. We are unlikely to make meaningful progress in strengthening graduate and postgraduate training on working collaboratively with the health system until we have a better understanding of how students are currently engaging in research partnership approaches. In response, this scoping review aims to map and characterise the evidence related to using an IKT or other research partnership approach from the perspective of health research trainees.Methods and analysisWe will employ methods described by the Joanna Briggs Institute and Arksey and O’Malley’s framework for conducting scoping reviews. The reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for scoping reviews checklist. We will include both published and unpublished grey literature and search the following databases: MEDLINE, Embase, CINAHL, PsycINFO, ProQuest Dissertations & Theses Global databases, Google Scholar and websites from professional bodies and other organisations. Two reviewers will independently screen the articles and extract data using a standardised data collection form. We will narratively describe quantitative data and conduct a thematic analysis of qualitative data. We will map the IKT and other research partnership activities onto the Knowledge to Action cycle and IAP2 Levels of Engagement Framework.Ethics and disseminationNo ethical approval is required for this study. We will share the results in a peer-reviewed, open access publication, conference presentation and stakeholder communications.
Modelling palliative and end-of-life resource requirements during COVID-19: implications for quality care
Authors: Chalk Daniel , Robbins Sara , Kandasamy Rohan , Rush Kate , Aggarwal Ajay , Sullivan Richard , Chamberlain Charlotte 
Published: May 2021

ObjectivesThe WHO estimates that the COVID-19 pandemic has led to more than 1.3 million deaths (1 377 395) globally (as of November 2020). This surge in death necessitates identification of resource needs and relies on modelling resource and understanding anticipated surges in demand. Our aim was to develop a generic computer model that could estimate resources required for end-of-life (EoL) care delivery during the pandemic.SettingA discrete event simulation model was developed and used to estimate resourcing needs for a geographical area in the South West of England. While our analysis focused on the UK setting, the model is flexible to changes in demand and setting.ParticipantsWe used the model to estimate resourcing needs for a population of around 1 million people.Primary and secondary outcome measuresThe model predicts the per-day ‘staff’ and ‘stuff’ resourcing required to meet a given level of incoming EoL care activity.ResultsA mean of 11.97 hours of additional community nurse time, up to 33 hours of care assistant time and up to 30 hours additional care from care assistant night sits will be required per day as a result of out of hospital COVID-19 deaths based on the model prediction. Specialist palliative care demand is predicted to increase up to 19 hours per day. An additional 286 anticipatory medicine bundles per month will be necessary to alleviate physical symptoms at the EoL care for patients with COVID-19: an average additional 10.21 bundles of anticipatory medication per day. An average additional 9.35 syringe pumps could be needed to be in use per day.ConclusionsThe analysis for a large region in the South West of England shows the significant additional physical and human resource required to relieve suffering at the EoL as part of a pandemic response.
Impact of home telemonitoring and management support on blood pressure control in non-dialysis CKD: a systematic review protocol
Authors: Okpechi Ikechi G , Muneer Shezel , Tinwala Mohammed M , Zaidi Deenaz , Hamonic Laura N , Braam Branko , Jindal Kailash , Klarenbach Scott , Padwal Raj S , Shojai Soroush , Thompson Stephanie , Bello Aminu K 
Published: May 2021

IntroductionHypertension is a common public health problem and a key modifiable risk factor for cardiovascular (CV) and chronic kidney disease (CKD). Home blood pressure (BP) telemonitoring (HBPT) and management is associated with improved BP control, accelerated delivery of care and decision-making strategies that can reduce adverse outcomes associated with hypertension. The aim of this paper is to describe the protocol for a systematic review to assess the impact of HBPT interventions used for improving BP control and reducing CV and kidney outcomes in non-dialysis CKD patients.MethodsWe developed this protocol using the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015. We will search empirical databases such as MEDLINE, Embase, Cochrane Library, CINAHL, Web of Science and PsycINFO and grey literature for studies conducted in non-dialysis CKD patients on interventions using HBPT and reporting outcomes related to BP control and other outcomes such as CV events and kidney disease progression. All studies meeting these criteria, in adults and published from inception until 2020 with no language barrier will be included.Ethics and disseminationEthical approval will not be required for this review as the data used will be extracted from already published studies with publicly accessible data. As this study will assess the impact of HBPT on BP control in non-dialysis CKD patients, evidence gathered through it will be disseminated using traditional approaches that includes open-access peer-reviewed publication, scientific presentations and a report. We will also disseminate our findings to appropriate government agencies.PROSPERO registration numberCRD42020190705).
Knowledge and prevalence of energy drinks consumption in Shanghai, China: a cross-sectional survey of adolescents
Authors: Luo Ruyan , Fu Rao , Dong Lu , Du Zheyi , Sun Wei , Zhao Min , Du Jiang 
Published: May 2021

BackgroundIn recent years, energy drinks (EDs) have been widely used among young people around the world. The extensive use of EDs also affects the sleep and exercise of adolescents.AimsThis study aimed to investigate the consumption of EDs, the knowledge, attitude towards EDs and associated factors of EDs consumption among adolescents in Shanghai, China.MethodsA total of 4608 adolescents completed a self-administered questionnaire assessing EDs use history, knowledge and attitude towards EDs. Adolescent Self-rating Life Events Checklist (ASLEC) was used to assess their life events. All participants were divided into two groups based on whether they used them or not. t-test and χ2test were used to compare the differences between the two groups, and binary logistic regression analysis was used to investigate the related factors for EDs consumption.Results70.5% of the participants reported having ever used EDs. The main avenues to getting information on EDs were from advertisements. 67.56% of them believed that EDs had adverse effects on health. 22.09% of the participants and 31.55% of their parents took a negative attitude towards EDs. Compared with the non-consumption group, participants in the consumption group were likely to be male, with older age, identified EDs more correctly and did not believe EDs had adverse effects, with more positive attitude and higher ASLEC score. Logistic regression results showed that gender, age, attitude of parents and themselves, knowledge of EDs and ASLEC score significantly predicted EDs consumption.ConclusionEDs consumption was popular among adolescents in Shanghai, and the tailored intervention programmes need to be developed based on the characteristics of adolescents.
T cell engaging bispecific antibodies targeting CD33 IgV and IgC domains for the treatment of acute myeloid leukemia
Authors: Hoseini Sayed Shahabuddin , Vadlamudi Mallika , Espinosa-Cotton Madelyn , Tran Hoa , Feng Yi , Guo Hong-fen , Xu Hong , Cheung Irene , Cheung Nai-Kong V 
Published: May 2021

BackgroundAcute myeloid leukemia (AML) remains one of the most challenging hematological malignancies. Despite progress in therapeutics, majority of patients succumb to this neoplasm. CD33 is a proven therapeutic target, given its expression on most AML cells. Almost all anti-CD33 antibodies target the membrane distal immunoglobulin V (IgV) domain of the CD33 extracellular domain.MethodsIn this manuscript, we present data on three bispecific antibodies (BsAbs) against the CD33 IgV and membrane proximal immunoglobulin C (IgC) domains. We use in vitro binding and cytotoxicity assays to show the effect of these BsAbs on AML cell lines. We also use immunodeficient mice-bearing leukemias from cell lines and patient-derived xenografts to show the effect of these BsAbs in vivo.ResultsIn vitro, the IgV-targeting BsAb had higher binding to AML cell lines using flow cytometry and delivered more potent cytotoxicity in T-cell-dependent cytotoxicity assays; importantly, the IgC domain-targeting outperformed the IgV domain-targeting BsAb in medullary and extramedullary leukemia animal models.ConclusionsThese data support further clinical development of this BsAb for first-in-human phase I clinical trial.
Bridging versus direct endovascular therapy in basilar artery occlusion
Authors: Nappini Sergio , Arba Francesco , Pracucci Giovanni , Saia Valentina , Caimano Danilo , Limbucci Nicola , Renieri Leonardo , Zini Andrea , Inzitari Domenico , Toni Danilo , Mangiafico Salvatore 
Published: May 2021

BackgroundWe evaluated safety and efficacy of intravenous recombinant tissue Plasminogen Activator plus endovascular (bridging) therapy compared with direct endovascular therapy in patients with ischaemic stroke due to basilar artery occlusion (BAO).MethodsFrom a national prospective registry of endovascular therapy in acute ischaemic stroke, we selected patients with BAO. We compared bridging and direct endovascular therapy evaluating vessel recanalisation, haemorrhagic transformation at 24–36 hours; procedural complications; and functional outcome at 3 months according to the modified Rankin Scale. We ran logistic and ordinal regression models adjusting for age, sex, National Institutes of Health Stroke Scale (NIHSS), onset-to-groin-puncture time.ResultsWe included 464 patients, mean(±SD) age 67.7 (±13.3) years, 279 (63%) males, median (IQR) NIHSS=18 (10–30); 166 (35%) received bridging and 298 (65%) direct endovascular therapy. Recanalisation rates and symptomatic intracerebral haemorrhage were similar in both groups (83% and 3%, respectively), whereas distal embolisation was more frequent in patients treated with direct endovascular therapy (9% vs 3%; p=0.009). In the whole population, there was no difference between bridging and direct endovascular therapy regarding functional outcome at 3 months (OR=0.79; 95% CI=0.55 to 1.13). However, in patients with onset-to-groin-puncture time ≤6 hours, bridging therapy was associated with lower mortality (OR=0.53; 95% CI=0.30 to 0.97) and a shift towards better functional outcome in ordinal analysis (OR=0.65; 95% CI=0.42 to 0.98).ConclusionsIn ischaemic stroke due to BAO, when endovascular therapy is initiated within 6 hours from symptoms onset, bridging therapy resulted in lower mortality and better functional outcome compared with direct endovascular therapy.
Energy harvesting from car suspension using a single magnet device
Authors: Chiu Min-Chie , Karkoub Mansour , Her Ming-Guo 
Published: May 2021

The need for renewable energy sources and harvesting devices has increased over the years for environmental and economical reasons. Cars, for example, have gone through important transformations over the past decade, which led to the inception of the hybrid type. The idea is to harness some of the dissipated energy and reuse it to operate a vehicle. A lot of energy is dissipated into the environment from the suspension system; therefore, harnessing that energy could be very useful for powering up electrical systems in a car. A magnetic mass-spring system to harvest the vibrational energy dissipated from the car’s suspension system that maximizes electricity generation and minimizes ride discomfort is presented in this work. The comfort level for the passenger via three dimensionless indices, including a regenerated electricity transmissibility, displacement transmissibility performance, and ride comfort performance, is introduced. To maximize the regenerated electricity indicator and minimize the discomfort indices, a multi-objective function based on the above indices and three weighted factors in conjunction with the Simulated Annealing method is used to obtain the optimal physical parameters for the harvesting device. The theoretical developments are demonstrated under constant and varied driving speeds, and the simulation results show that the energy harvester is capable of producing reasonable amounts of electricity while maintaining a good comfort level. In fact, it was shown that the harvester can generate 0.045 V when the car travels at 60 km/h with an acceleration of 0.43 m/s2 and assumed base excitation amplitude of 0.05 m. Higher voltages were achievable with larger base excitation amplitudes and (or) accelerations.
ESS Cryogenic Controls Design
Authors: Arnold P. , Boros M. , Nilsson P. 
Published: May 2021

AbstractThe European Spallation Source (ESS) is a neutron-scattering facility funded and supported in collaboration with 13 European countries in Lund, Sweden. Cryogenic cooling at ESS is vital particularly for the linear accelerator, the hydrogen target moderators, a test stand for cryomodules, the neutron instruments and their sample environments. The paper will focus on the control system design for the different cryogenic subsystems, hardware and software selected, industry and in-house development, advantages and disadvantages of the chosen setup and operational experience. There is also a lessons learned, feedback from providers and stakeholders and an outlook for further development described.
Genomics, Transcriptomics, and Minimal Residual Disease Detection: The Winning Team to Guide Treatment of Acute Lymphoblastic Leukemia
Authors: Segers Heidi , Cools Jan 
Published: May 2021

Abstract
Summary: Cytogenetics supported by additional molecular analyses and minimal residual disease detection have been successfully combined to improve the outcome of childhood acute lymphoblastic leukemia (ALL). Results from the St. Jude Total Therapy Study 16 demonstrate that some of the recently identified ALL subtypes can further guide risk stratification.
See related article by Jeha et al., p. 326.
Idosos atendidos em um Serviço de Urgência e Emergência Psiquiátrica
Authors: Cordeiro Mayara Giuli dos Santos , Otani Márcia Aparecida Padovan , Goulart Flávia Cristina , Pinheiro Osni Lazaro , Marin Maria José Sanches , Lazarini Carlos Alberto 
Published: May 2021

Objetivo: caracterizar os idosos atendidos em um Serviço de Urgência e Emergência Psiquiátrica quanto ao perfil sociodemográfico, diagnóstico psiquiátrico, prescrição de medicamentos e conduta médica e avaliar suas associações com o sexo. Método: estudo transversal, quantitativo, em que os dados foram obtidos a partir dos prontuários de pacientes atendidos no referido serviço, entre julho/2015 e junho/2016. A variável independente foi o sexo e as dependentes foram: idade; procedência; informante; tratamento psiquiátrico anterior; diagnóstico; medicamentos prescritos e conduta. Resultados: nos 152 prontuários analisados, observam-se idade prevalente entre 60 a 69 anos, maioria de mulheres, procedência do município local e comparecimento com acompanhante. Os diagnósticos prevalentes são a esquizofrenia e os transtornos mentais e comportamentais decorrentes do uso de substâncias psicoativas. As medicações prescritas com maior frequência são da classe dos antipsicóticos e anti-histamínicos, seguidas dos ansiolíticos/sedativos. O critério de Beers considera a prescrição de medicamentos do grupo dos benzodiazepínicos, antipsicóticos e anti-histamínicos inapropriada para idosos. A principal conduta foi a alta, sem encaminhamento a outro serviço. Conclusão: embora haja incentivo do Ministério da Saúde, com a criação de novas políticas de saúde mental, muitos profissionais mantêm o modelo de atendimento baseado na queixa e conduta, dificultando a reabilitação psicossocial dos pacientes.
Binge drinking e fatores associados em indígenas da etnia Karipuna
Authors: Castelo-Branco Fernanda Matos Fernandes , Vargas Divane de 
Published: May 2021

Objetivo: identificar a prevalência do uso em binge em indígenas Karipuna e verificar a associação desse uso com variáveis sociodemográficas, clínicas e comportamentais da amostra. Método: trata-se de um estudo transversal realizado com 230 indígenas de 12 aldeias Karipuna em Oiapoque. Obteve-se o rastreio do uso em binge por meio da Questão-Chave. Coletaram-se os dados entre maio e dezembro de 2017. Realizaram-se, a priori, a análise de frequência das variáveis envolvidas no estudo e, na sequência, o teste qui-quadrado e o modelo de regressão logística. Resultados: revela-se que a prevalência do uso em binge foi de 24,8% de uma a três vezes; de 20,4% de quatro a seis vezes; de 12,2% de sete a dez vezes e de 9,6% em mais de dez vezes. Associaramse os seguintes fatores: estudante (OR=2,99); migração da aldeia de origem (OR=2,22); uso de preservativo (OR=2,62) e relações sexuais após o consumo de álcool (OR=1,61).Conclusão: alerta-se que o uso ocasional de risco de álcool demanda consideração, bem como o conhecimento das particularidades da população ora investigada, a fim de estabelecer controle, planejamento de recursos terapêuticos para que se alcancem resultados efetivos nas ações planejadas e principalmente nas que são adotadas na prática a fim ...
Treinamento em transtornos mentais comuns na enfermaria: uso de metodologias ativas na construção do cuidado
Authors: Machado Marília Girão de Oliveira , Sampaio Cynthia Lima 
Published: May 2021

Objetivo: analisar a percepção de enfermeiras atuantes em leitos psiquiátricos de um hospital geral sobre a realização de um treinamento em saúde mental com a utilização de metodologias ativas. Método: pesquisa do tipo descritiva, exploratória, com abordagem qualitativa, realizada em um hospital geral de grande porte, com cinco enfermeiras, no período de junho a novembro de 2019. A coleta de dados consistiu em duas etapas: realização e avaliação do treinamento. Para a realização do treinamento, utilizaram-se metodologias ativas, com foco na aprendizagem baseada em problemas e problematização. A avaliação do treinamento foi realizada por meio de entrevista semiestruturada, elaborada segundo o modelo proposto por Kirkpatrick, e os dados analisados por meio da análise de conteúdo temática de Bardin. Resultados: os enfermeiros consideraram o treinamento positivo e desenvolveram habilidades como abordagem terapêutica, escuta ativa e mudança de comportamento. Conclusão: o treinamento foi eficaz na construção do conhecimento, promovendo transformações e reflexões significativas na aprendizagem de enfermeiros, além de contribuir com a produção de habilidades e atitudes na área de saúde mental, valorizando a aprendizagem significativa.
Novel Use of the Buccal Fat Pad for Sinocutaneous Fistulae Closure and a Review of Reconstructive Options
Authors: Pool Christopher , Goyal Neerav , Lighthall Jessyka G. 
Published: May 2021

Background: Sinocutaneous fistulae (SCF) are abnormal communications between the paranasal sinuses and the overlying skin. They may be difficult to manage due to facial geometry, scar contraction, and poor tissue vascularity. We describe a novel use of the buccal flap and review the literature to examine management options for this disease process. Methods: A PubMed/MEDLINE literature search was performed for studies published between January 1, 1950 and April 29, 2020 that describe management strategies for SCF. The clinical record, imaging, and operative reports were reviewed of the case in which the buccal fat flap was used in reconstruction. Results: A total of 359 articles were retrieved. After removing duplicate articles, non-English studies, animal studies, duplicate articles and studies that mentioned SCF without specific mention of management strategies, 51 articles were reviewed. Management paradigms throughout the articles include (1) removal of infection, (2) ensuring patency of sinus outflow tracts, (3) tensionless multilayered closure using well vascularized tissue, and (4) prevention or minimization of future risk factors for fistula formation. Conclusion: This article informs surgeons on reconstructive options for sinocutaneous fistulae including a novel description of the buccal fat flap.
Electronic Health Records’ Support for Primary Care Physicians’ Situation Awareness: A Metanarrative Review
Authors: Savoy April , Patel Himalaya , Murphy Daniel R. , Meyer Ashley N. D. , Herout Jennifer , Singh Hardeep 
Published: May 2021

Objective Situation awareness (SA) refers to people’s perception and understanding of their dynamic environment. In primary care, reduced SA among physicians increases errors in clinical decision-making and, correspondingly, patients’ risk of experiencing adverse outcomes. Our objective was to understand the extent to which electronic health records (EHRs) support primary care physicians (PCPs)’ SA during clinical decision-making. Method We conducted a metanarrative review of papers in selected academic databases, including CINAHL and MEDLINE. Eligible studies included original peer-reviewed research published between January 2012 and August 2020 on PCP–EHR interactions. We iteratively queried, screened, and summarized literature focused on EHRs supporting PCPs’ clinical decision-making and care management for adults. Then, we mapped findings to an established SA framework to classify external factors (individual, task, and system) affecting PCPs’ levels of SA (1–Perception, 2–Comprehension, and 3–Projection) and identified SA barriers. Results From 1504 articles identified, we included and synthesized 19 studies. Study designs were largely noninterventional. Studies described EHR workflow misalignments, usability issues, and communication challenges. EHR information, including lab results and care plans, was characterized as incomplete, untimely, or irrelevant. Unmet information needs made it difficult for PCPs to obtain even basic SA, Level 1 SA. Prevalent barriers to PCPs developing SA with EHRs were errant mental models, attentional tunneling, and data overload. Conclusion Based on our review, EHRs do not support the development of higher levels of SA among PCPs. Review findings suggest SA-oriented design processes for health information technology could improve PCPs’ SA, satisfaction, and decision-making.