bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-objective aerodynamic optimization design of variable camber leading and trailing edge of airfoil
Authors: Bao Nvzi , Peng Yehui , Feng Heying , Yang Chenghao 
Published: December 2021

Variable camber is an effective method for improving the flight efficiency of large aircraft, and has attracted the attention of researchers. This work focused on the optimization of a variable camber airfoil. First, the influences of the variable camber of the leading and trailing edges on the airfoil aerodynamic performance were investigated using a computational fluid dynamics numerical simulation. An initial database was established for a deep neural network. Second, an iterative algorithm was constructed to optimize the variable camber airfoil in terms of the rotation angle of the leading edge, deflection position of the leading edge, rotation angle of the trailing edge, and deflection position of the trailing edge. A genetic algorithm was used in each iteration to maximize the lift coefficient and lift-to-drag ratio, as predicted using a deep neural network (DNN). The optimal results were validated using Fluent. If the DNN result approximated the Fluent results, the iterative process was stopped. Otherwise, the Fluent results were inserted into the database to update the DNN prediction model. The optimization results showed that the lift-to-drag ratio of the 2D airfoil could be increased by more than 14 when the angle of attack was less than 8° relative to the original airfoil. Furthermore, to validate the 2D optimal results, the optimized 2D airfoil was stretched into 3D, and it was discovered that the aerodynamic performance trend of the 3D airfoil with respect to the angle of attack was basically the same as that of the 2D airfoil. In addition, the corresponding 3D airfoil improved the aerodynamic performance and reduced the noise at a high frequency (by approximately 16 dB). In contrast, the noise in the low and medium frequencies remained unchanged. Therefore, the optimization method and results can provide a reference for the aerodynamic design and acoustic design of large civil aircraft wings.
Screening for cognitive impairment in systemic lupus erythematosus: Application of the Montreal Cognitive Assessment (MoCA) in a Greek patient sample
Authors: Papastefanakis Emmanouil , Dimitraki Georgia , Ktistaki Georgia , Fanouriakis Antonis , Karamaouna Penny , Bardos Achilles , Kallitsakis Ioannis , Adamichou Christina , Gergianaki Irini , Repa Argyro , Bertsias George , Sidiropoulos Prodromos , Karademas Evangelos , Simos Panagiotis 
Published: December 2021

Background Cognitive impairment (CI) is one of the most frequent neuropsychiatric manifestations of systemic lupus erythematosus (SLE). Given that extensive neuropsychological testing is not always feasible in routine clinical practice, brief cognitive screening tools are desirable. The aim of this study was to evaluate the Montreal Cognitive Assessment (MoCA) as a screening tool for CI in SLE. Methods Consecutive SLE patients followed at a single centre were evaluated using MoCA and an extensive neuropsychological test battery (NPT), including the Digits Forward and Digits Backwards, Rey Auditory Verbal Learning Memory Test, Trail Making Test, Stroop Colour-Word Test, Semantic and Phonetic Verbal Fluency tests and a 25-problem version of the General Adult Mental Ability test. The criterion validity of MoCA was assessed through receiver operating characteristic (ROC) analyses using three different case definitions: i) against normative population data, ii) and iii) against average performance of a comparison group of rheumatoid arthritis (RA) patients, to adjust for possible confounding effects of chronic illness and inflammatory processes on cognitive performance. The effect of patient-related (age, years of education, anxiety, depression, fatigue and pain) and disease-related (activity, damage, age at diagnosis, disease duration, use of glucocorticoid, psychotropic and pain medication) parameters on the MoCA was examined. Results A total of 71 SLE patients were evaluated. MoCA significantly correlated with all NPT scores and was affected by education level ( p < 0.001), but not by other demographic or clinical variables. The optimal cutoff for detecting CI, as defined on the basis of normative population data, was 23/30 points, demonstrating 73% sensitivity and 75% specificity. A cutoff of 22/30 points, using neuropsychological profiles of the RA group as inflammatory disease controls, exhibited higher sensitivity (100%, based on both definitions) and specificity (87% and 90%, depending on the definition). The standard cutoff of 26/30 points displayed excellent sensitivity (91–100%) with significant expenses in specificity (43–45%). Conclusion The MoCA is an easily applied tool, which appears to be reliable for identifying CI in SLE patients. The standard cutoff score (26/30) ensures excellent sensitivity while lower cutoff scores (22–23/30) may, also, provide higher specificity.
Comparing pregnancy outcomes in patients with criteria and non-criteria autoimmune disease: A systematic review
Authors: Muñoz Muñoz Candido , Ahmed Kawser , Thomas Mari , Cohen Hannah , Alijotas-Reig Jaume , Giles Ian 
Published: December 2021

Background Not all patients fulfil criteria for specific autoimmune rheumatic diseases (ARDs) and are then defined as having non-criteria (nc)ARD. It is uncertain whether well-recognised associations with adverse pregnancy outcomes in patients with criteria ARD also exist in patients with ncARD or undifferentiated connective tissue disease (UCTD). Therefore, we undertook a systematic review of the prevalence of adverse pregnancy outcomes in various ncARD and UCTD compared with criteria ARD to identify whether there are increased risks and to examine for any benefits of treatment. Methods This study was conducted in accordance with the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. A systematic literature review was performed using online databases including Medline and PubMed from inception to the beginning of April 2021 using appropriate keywords for various ARD and pregnancy outcomes. Results After screening 665 articles, 36 articles were chosen for full text review and 15 selected for final analysis. There were eight studies of nc antiphospholipid syndrome (APS) of more than 7000 pregnancies and seven studies of UCTD of more than 1000 pregnancies. No studies of any other ncARD in pregnancy were identified. We found that patients with either ncAPS or UCTD seem to have an increased burden of poor pregnancy outcomes compared with the general population. Despite the heterogeneity and poor quality of the studies, we also noted that ncAPS and criteria APS patients may have similar rates of obstetric complications with standard and/or non-standard APS treatment regimens. Conclusion Our findings of increased risks of poor pregnancy outcomes in patients with ncAPS or UCTD will be helpful for pre-pregnancy counselling and management of these patients in pregnancy and support their referral to specialist obstetric-rheumatology and obstetric-haematology clinics.
Influence of the printing parameters on the properties of Poly(lactic acid) scaffolds obtained by fused deposition modeling 3D printing
Authors: Nascimento Abraão CD , Mota Raquel CDAG , Menezes Livia RD , Silva Emerson OD 
Published: December 2021

3D printing techniques are of great interest in the sector of scaffold development aiming for bone tissue regeneration mainly due to the possibility of customizing the scaffold according to the area of the bone defect to be regenerated. Among the 3D printing techniques, the fused deposition modeling (FDM) stands out as promising because it does not require the use of solvents and toxic components throughout the manufacturing process of the scaffold. In this sense, the present article aims to evaluate the influence of the printing speed and the temperature of the printing head on the properties of poly(lactic acid) scaffolds. Three speeds of the printing head (4600 mm/min, 480 mm/min, and 500 mm/min) and two different extrusion temperatures (200oC and 220oC) were evaluated, maintaining the architecture and all other printing conditions constant. After obtaining the scaffolds, they were characterized by the following techniques: Fourier transform infrared (FTIR) analysis, X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), time-domain nuclear magnetic resonance (TD-NMR), compressive modulus, L929 cell viability, and enzymatic degradation. The results obtained showed that the increase in printing temperature and speed was able to influence some properties of the material: increase crystallinity, compressive modulus, thermal resistance, and reduce molecular mobility and enzymatic degradation rate of the scaffolds. These findings are promising and indicate that, by altering only the basic parameters of 3D printing, it is possible to modulate the properties of the scaffolds obtained, to achieve greater crystallinity and a superior compressive modulus.
Effects of recovered brown alumina filler loading on mechanical, hygrothermal and thermal properties of glass fiber–reinforced epoxy polymer composite
Authors: Sabarinathan P , Annamalai VE , Rajkumar K , Vishal K 
Published: December 2021

This study investigates the efficiency of recovered brown alumina (RBA) particles filled in epoxy glass-fiber composites. The RBA particles were obtained from grinding wheel rejects with the help of the mechanical crushing process. Recovered particles finer than 120 grit were used as particulate filler for composite preparation. Composites were processed through a hand-layup technique by varying RBA filler loading percentages (0, 5, 10, 15, and 20 wt.%) in a glass fiber–reinforced epoxy matrix. Physical, mechanical, water absorption, and thermal properties of the composites were tested experimentally. By suitable addition of RBA, it is possible to tailor the shore-D hardness, tensile modulus, flexural strength, flexural modulus, and maximum degradation temperature. The 20%-filled RBA composite shows the maximum flexural strength of 382 MPa, and the shore-D hardness value was 85. The fracture surface shows a failure mechanism dominated by matrix cracking and debonding of fiber/particles from the interface. Hygrothermal testing of the RBA20-filled composite reveals 9% and 4% reduction in tensile and flexural properties. The thermal stability of the glass fiber–reinforced composite improves as the filler percentage increases. Maximum thermal stability of 435°C was observed in 20%-filled RBA polymer composite.
Biotribological performance of medical-grade UHMW polyethylene-based hybrid composite for joint replacement
Authors: Hussain Omar , Ahmad Babar , Sheikh Shahid Saleem 
Published: December 2021

Ultra high molecular weight polyethylene (UHMWPE) is widely used for articulating surfaces in total hip and knee replacements. In the present work, the tribological properties of UHMWPE-based nano composites were studied in order to meet the demands of current bearing applications. UHMWPE matrix reinforced with 0.5, 1, and 2 weight percentage of alumina nano powder were fabricated by hot pressing. The dispersion and microstructure of composite material was established by X-ray diffraction (XRD) and scanning electron microscope (SEM) micrograph. The tests were carried out on a reciprocating sliding pin-on-disc tribometer at human body temperature (37±1°C) under dry and human serum lubricating environments for a normal load of 46 N and 52 N, a constant sliding speed of 4 mm. Under these testing conditions, it has been observed that the wear behavior of the developed composites improved with increase in weight percentage of alumina nano powder. The results show that at 52 N load, the maximum value of wear rate was 7.9x10−7 mm3/Nm and the minimum value 1.6x10−7 mm3/Nm was obtained. SEM was used to examine the worn surface and it was observed that human serum adheres to the surface of the composite pins upon sliding, resulting in the formation of a film which results in better wear resistance of the composite pins under human serum lubrication than dry sliding. This study implies that the use of nano alumina power will reduce the wear of UHMWPE based composite under human serum lubrication.
Relieving from Breathlessness in the Wind: A Meta-Analysis and Subjective Report of Effectiveness of Fan Blowing in Patients with Cardiorespiratory Diseases or Cancer
Authors: Tsai Jing-Jing , Chen Kee-Hsin , Fang Hui-Fen , Huang Tsai-Wei 
Published: December 2021

Objectives Breathlessness is common among terminally ill patients with cardiorespiratory disease or cancer. The experience may induce secondary physiological and behavioral responses that limit patient well-being and independence and cause emotional distress. Methods We conducted a meta-analysis on randomized controlled trials (RCTs) that examined the effectiveness of fan blowing on breathlessness among patients with cardiorespiratory diseases or cancer. The PubMed, Cochrane Library, Embase, SCOPUS, and CINAHL databases were searched to retrieve potential articles. The primary outcome was breathlessness severity. The secondary outcomes were SpO2, anxiety, depression, and quality of life. Also, we presented the changes of vital signs and subjective feeling of a male patient who used fan blowing for relieving his breathlessness. Results Eight RCTs were available for analysis. The pooled results demonstrated no significant difference in breathlessness severity between fan-to-face blowing and control methods (standard mean difference: −0.21, 95% confidence interval: −.59 to .17); however, a significant reduction in breathlessness severity was observed in the short-time intervention compared with long-time intervention. A trend occurred toward significance in the reduction of respiratory rate in fan-to-face blowing compared with control methods (MD: −.64, 95% CI: −1.37 to .09). No differences were observed between groups in oxygen saturation, anxiety, depression, or QoL. The male patient who used fan blowing showed an improved vital signs and a satisfied subjective feeling. Conclusions Consistent short-time fan-to-face blowing is effective for relieving breathlessness among conscious terminally ill patients with cardiorespiratory diseases or cancer. The use of this convenient method for relieving breathlessness symptoms in terminally ill patients is recommended.
Long-Term Follow-up of Unilateral Cleft lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation
Authors: Gustafsson Charlotta , Heliövaara Arja , Leikola Junnu 
Published: December 2021

Objective The ideal surgical protocol and technique for primary closure of unilateral cleft lip and palate (UCLP) are unclear, and the development of velopharyngeal insufficiency and fistulae following primary repair is common. This study aimed to determine the long-term surgical burden of care in terms of secondary surgeries, defined as speech-correcting surgeries (SCSs) and fistula repair, in a UCLP population, and to compare outcomes of various surgical protocols. Design Retrospective, single-center review. Participants The study comprised 290 nonsyndromic children with complete UCLP. Different surgical protocols entailing both single-stage and 2-stage approaches were compared, and the surgical outcome was analyzed at the time of alveolar bone grafting (ABG) and post ABG. Results Altogether 110 children (37.9%) underwent secondary surgery by the time of ABG. Of the total population 25.9% (n  =  75) had undergone SCS and 17.2% (n  =  50) had undergone fistula repair. The respective incidences at follow-up (post ABG) were 30.3% (n  =  88) and 18.9% (n  =  55). Median age at ABG was 9.8 years and at follow-up was 16.3 years. No significant difference emerged in terms of secondary surgeries between the techniques and protocols applied at primary repair. However, some differences occurred regarding the location of fistulae; the single-stage procedure had more anterior fistula repairs, particularly connected to a perialveolar fistula. Conclusions Although the outcome differences between the surgical protocols were small, indicating that none of the treatment protocols was clearly superior to another, attention was drawn to the favorable outcomes of the single-stage protocol.
Rethinking the Rule of 10s: Early Cleft Lip Repair Improves Weight Gain
Authors: Kondra Katelyn , Stanton Eloise , Jimenez Christian , Ngo Kalvyn , Wlodarczyk Jordan , Jacob Laya , Munabi Naikhoba C.O. , Chen Kevin , Urata Mark M. , Hammoudeh Jeffrey A. 
Published: December 2021

Objective This study compares patients undergoing early cleft lip repair (ECLR) (<3-months) and traditional lip repair (TLR) (3-6 months) with/without nasoalveolar molding (NAM) to evaluate the effects of surgical timing on weight gain in hopes of guiding future treatment paradigms. Design Retrospective review. Setting Children's Hospital of Los Angeles, California. Patient, Participants A retrospective chart review evaluated patients who underwent ECLR or TLR ± NAM from November 2009 through January 2020. Interventions No intervention was performed. Main Outcome Measure(s) Patient demographics, birth and medical history, perioperative variables, and complications were collected. Infant weights and age-based percentiles were recorded at birth, surgery, 8-weeks, 6-months, 12-months, and 24-months postoperatively. The main outcomes were weight change and weight percentile amongst ECLR and TLR ± NAM groups. Results 107 patients met inclusion criteria: ECLR, n = 51 (47.6%); TLR + NAM, n = 35 (32.7%); and TLR-NAM, n = 21 (19.6%). ECLR patients had significantly greater changes in weight from surgery to 8-weeks and from surgery to 24-months postoperatively compared with both TLR ± NAM ( P < .05). Age-matched weights in the ECLR group were significantly greater than TLR ± NAM at multiple time points postoperatively ( P < .05). Conclusions ECLR significantly increased patient weights 24-months postoperatively when compared to TLR ± NAM. Specifically compared to TLR-NAM, ECLR weights were significantly greater at all time points past 6-months postoperatively. The results of this study demonstrate that ECLR can mitigate feeding difficulties and malnutrition traditionally seen in patients with cleft lip.
A Three-Dimensional-Based Morphometric Analysis of a Standardized Overcorrection Technique for Fronto-Orbital Advancement in Metopic Craniosynostosis
Authors: Pfaff Miles J. , Bruce Madeleine K. , Erpenbeck Sarah , Mittal Aditya , Beiriger Justin W. , Zhu Xiao , Dvoracek Lucas , Goldstein Jesse A. 
Published: December 2021

Introduction The concept of “overcorrection” for trigonocephaly has been reported to achieve both anterior cranial fossa expansion and normalization of craniofacial form. The purpose of this study is to describe in detail a standardized technique to fronto-orbital advancement utilizing the concept of “overcorrection” and objectively evaluate intermediate results. Methods This retrospective study included patients with isolated metopic synostosis who underwent surgery via the proposed surgical technique and age and sex-matched unaffected controls. Craniofacial morphometric analysis was performed on pre-, immediate post-, and intermediate postoperative (>2 years) three-dimensional (3D)-rendered computed tomographic (CT) scans and photographs. Key CT-based measurements included interzygomaticofrontal suture distance (IZFS), endocranial bifrontal angle (ECA), and temporal expansion. 3D photogrammetry was performed using established measurements and associated Z-scores converted. A Paired t-test and analysis of variance were performed when appropriate. Results Forty-one patients were included. A comparison of pre- and immediate postoperative CT scans demonstrated statistically significant increases in all measurements. Subset analysis of 12 patients with intermediate follow-up (age: 39.6 ± 3.6 months) demonstrated significant differences from preoperative values except for IZFS, which decreased from immediate postoperative values and was smaller than age- and sex-matched controls. 3D photogrammetry demonstrated a mean Z-score above the norm for frontal breath. 3D photogrammetry is also positively correlated with CT-based measurements. Conclusions This standardized “overcorrection” approach for trigonocephaly can provide the appropriate changes to maintain a normal ECA despite a reduction in bifrontal width over time. 3D photogrammetry positively correlated with CT-based measurements and may provide useful information when following patients clinically. Long-term follow-up assessment to determine the necessary degree of overcorrection at skeletal mature is needed.
Quantifying ADHD Symptoms in Open-Ended Everyday Life Contexts With a New Virtual Reality Task
Authors: Seesjärvi Erik , Puhakka Jasmin , Aronen Eeva T. , Lipsanen Jari , Mannerkoski Minna , Hering Alexandra , Zuber Sascha , Kliegel Matthias , Laine Matti , Salmi Juha 
Published: December 2021

Objective: To quantify goal-directed behavior and ADHD symptoms in naturalistic conditions, we developed a virtual reality task, EPELI (Executive Performance in Everyday LIving), and tested its predictive, discriminant and concurrent validity. Method: We collected EPELI data, conventional neuropsychological task data, and parent-ratings of executive problems and symptoms in 38 ADHD children and 38 typically developing controls. Results: EPELI showed predictive validity as the ADHD group exhibited higher percentage of irrelevant actions reflecting lower attentional-executive efficacy and more controller movements and total game actions, both indicative of hyperactivity-impulsivity. Further, the five combined EPELI measures showed excellent discriminant validity (area under curve 88 %), while the correlations of the EPELI efficacy measure with parent-rated executive problems ( r = .57) and ADHD symptoms ( r = .55) pointed to its concurrent validity. Conclusion: We provide a proof-of-concept validation for a new virtual reality tool for ecologically valid assessment of ADHD symptoms.