bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Post‐Shock Heating by Plastic Deformation During Impact Devolatilization of Calcite (CaCO3)
Authors: Kurosawa Kosuke , Genda Hidenori , Azuma Shintaro , Okazaki Keishi 
Published: March 2021

AbstractAn accurate understanding of the relationship between the impact conditions and the degree of shock‐induced thermal metamorphism in meteorites allows the impact environment in the early Solar System to be understood. A recent hydrocode has revealed that impact heating is much higher than previously thought. This is because plastic deformation of the shocked rocks causes further heating during decompression, which is termed post‐shock heating. Here we compare impact simulations with laboratory experiments on the impact devolatilization of calcite to investigate whether the post‐shock heating is also significant in natural samples. We calculated the mass of CO2 produced from the calcite, based on thermodynamics. We found that iSALE can reproduce the devolatilization behavior for rocks with the strength of calcite. In contrast, the calculated masses of CO2 at lower rock strengths are systematically smaller than the experimental values. Our results require a reassessment of the interpretation of thermal metamorphism in meteorites.
Distributed Global Debris Thickness Estimates Reveal Debris Significantly Impacts Glacier Mass Balance
Authors: Rounce D. R. , Hock R. , McNabb R. W. , Millan R. , Sommer C. , Braun M. H. , Malz P. , Maussion F. , Mouginot J. , Seehaus T. C. , Shean D. E. 
Published: March 2021

AbstractSupraglacial debris affects glacier mass balance as a thin layer enhances surface melting, while a thick layer reduces it. While many glaciers are debris‐covered, global glacier models do not account for debris because its thickness is unknown. We provide the first globally distributed debris thickness estimates using a novel approach combining sub‐debris melt and surface temperature inversion methods. Results are evaluated against observations from 22 glaciers. We find the median global debris thickness is ∼0.15 ± 0.06 m. In all regions, the net effect of accounting for debris is a reduction in sub‐debris melt, on average, by 37%, which can impact regional mass balance by up to 0.40 m water equivalent (w.e.) yr‐1. We also find recent observations of similar thinning rates over debris‐covered and clean ice glacier tongues is primarily due to differences in ice dynamics. Our results demonstrate the importance of accounting for debris in glacier modeling efforts.
Tonga Slab Morphology and Stress Variations Controlled by a Relic Slab: Implications for Deep Earthquakes in the Tonga‐Fiji Region
Authors: Liu Hao , Gurnis Michael , Leng Wei , Jia Zhe , Zhan Zhongwen 
Published: March 2021

AbstractDeep focus earthquakes within the Tonga‐Fiji subduction system account for about two‐thirds of the global total and provide significant constraints on slab deformation. The factors controlling the intense deformation remain unclear. Here, we use two‐dimensional, time‐dependent geodynamic models to study the morphology, stress state, and thermal structure of the Tonga‐Fiji subduction zone. The results, consistent with tomographic images and focal mechanisms, demonstrate that collision between a relic slab from the Vanuatu Trench and the Tonga slab may control the steeper dip of the Tonga slab and earthquakes in the mantle transition zone. We suggest that the magnitude 8.2 and 7.9 earthquakes in 2018 mostly ruptured within the warm rim of the Tonga slab and occurred beneath the folding relic slab with high temperatures of at least ∼900°C and ∼1100°C, respectively. The findings support the hypothesis that local slab temperature likely controls rupture of deep earthquakes.
BGC‐Argo Floats Observe Nitrate Injection and Spring Phytoplankton Increase in the Surface Layer of Levantine Sea (Eastern Mediterranean)
Authors: D'Ortenzio F. , Taillandier V. , Claustre H. , Coppola L. , Conan P. , Dumas F. , Durrieu du Madron X. , Fourrier M. , Gogou A. , Karageorgis A. , Lefevre D. , Leymarie E. , Oviedo A. , Pavlidou A. , Poteau A. , Poulain P. M. , Prieur L. , Psarra S. , Puyo‐Pay M. , Ribera d'Alcalà M. , Schmechtig C. , Terrats L. , Velaoras D. , Wagener T. , Wimart‐Rousseau C. 
Published: March 2021

AbstractIn the eastern Mediterranean Sea, satellites have observed events of spring surface‐chlorophyll increase in the Rhodes Gyre region recurring intermittently. Few in situ biogeochemical data, however, exist to confirm their consistency, elucidate their seasonal characteristics, or discriminate among the possible drivers. During the year 2018, an array of BGC‐Argo floats was deployed in the region, collecting the first‐ever annual time series of in situ profiles of biogeochemical parameters in this area. Their observations demonstrated that nitrates, driven by mixed‐layer dynamics, were available at surface from December 2018 onwards and could have sustained phytoplankton growth. Phytoplankton accumulation at the surface was observed by satellite only in March 2019 when the mixed‐layer depth shoaled. These findings confirm that blooms occurring before the start of seasonal stratification are not easily recorded by satellite observations and reaffirm the need to consolidate the BGC‐Argo network to establish time series of the evolution of biogeochemical processes.
Intermediate Aerosol Loading Enhances Photosynthetic Activity of Croplands
Authors: Wang Xin , Wang Chengzhang , Wu Jin , Miao Guofang , Chen Min , Chen Shuli , Wang Songhan , Guo Zhengfei , Wang Zhenhua , Wang Bin , Li Jing , Zhao Yujin , Wu Xiaolin , Zhao Chuanfeng , Lin Weili , Zhang Yongguang , Liu Lingli 
Published: March 2021

AbstractAerosols can affect crop photosynthesis by altering radiation and meteorological conditions. By combining field observations, mechanistic modeling, and satellite‐retrieved solar‐induced chlorophyll fluorescence (SIF), we assessed aerosols' impacts on crop photosynthesis from leaf to regional scale. We found that the initial increase in aerosol optical depth (AOD) enhanced photosynthesis of sun leaves, shade leaves, and canopy, which reached their maximum at AOD = 0.76, 1.13, and 0.93, respectively, and then decreased. Aerosol‐induced changes in radiation regime and the concurrent high relative humidity led to such nonlinear responses. Similarly, the SIF of croplands in the North China Plain (NCP) also showed a bell‐shaped response to aerosols. The optimal AOD level at which SIF reached the maximum value varied from 0.56 to 1.04, depending on the background meteorological conditions. Approximately 76%–90% of the NCP exceeded the optimal AOD level, suggesting that stringent aerosol pollution control could promote cropland productivity in this region.
Airborne Measurements of Contrail Ice Properties—Dependence on Temperature and Humidity
Authors: Bräuer T. , Voigt C. , Sauer D. , Kaufmann S. , Hahn V. , Scheibe M. , Schlager H. , Diskin G. S. , Nowak J. B. , DiGangi J. P. , Huber F. , Moore R. H. , Anderson B. E. 
Published: March 2021

AbstractThe largest share in the climate impact of aviation results from contrail cirrus clouds. Here, the dependence of microphysical contrail ice properties and extinction on temperature and humidity is investigated. Contrail measurements were performed at various altitudes during the 2018 ECLIF II/NDMAX campaign with the NASA DC‐8 chasing the DLR A320. Ice number concentrations and contrail extinction coefficients are largest at altitudes near 9.5 km, typical for short‐ and medium‐range air traffic. At higher altitudes near 11.5 km, low ambient water vapor concentrations lead to smaller contrail particle sizes and lower extinction coefficients. In addition, contrails were detected below 8.2 km near the Schmidt‐Appleman contrail formation threshold temperature. Here, only a small fraction (<15%) of the emitted soot particles were activated into ice. Our observations enhance the understanding of contrail formation near the formation threshold and give a glimpse on the altitude dependence of climate‐relevant contrail properties.
Blowing Snow at McMurdo Station, Antarctica During the AWARE Field Campaign: Surface and Ceilometer Observations
Authors: Loeb Nicole A. , Kennedy Aaron 
Published: March 2021

AbstractBlowing snow (BLSN) is an impactful process in cold climates, affecting regional thermodynamics, radiation properties, and the surface mass balance of snow. Though it has significant climatic impacts, the process is still poorly understood and not widely included in weather and climate models. In 2016, the AWARE Field Campaign saw the deployment of a large suite of in situ and remote sensing instruments to McMurdo Station, Antarctica allowing for investigation of BLSN. A ceilometer‐based BLSN detection algorithm used elsewhere in Antarctica is applied to data from AWARE, yielding a BLSN frequency of 14.1% compared to 8.2% as detected by human observers. To increase confidence in detections, the algorithm is updated to have shorter temporal averaging and to include a variety of meteorological thresholds to limit false detections due to fog. Efforts to incorporate a laser disdrometer into the algorithm were unsuccessful. An unphysical dependence of particle size distributions on wind speed is found suggesting observations are problematic at wind speeds greater than 10 m s−1. The revised algorithm detected a BLSN frequency of 7.4%, increasing agreement with human observations and confidence that the process is actively occurring at the observation site. These observations are put into context of a climatology of human observations of BLSN at McMurdo station from 2002–2018. An annual average of 8.0%–14.0% is estimated, with a total annual range of 3.4%–21.3%. Regardless of whether BLSN is observed by humans or instrument, the majority of cases at this location are associated with ongoing precipitation.
Late Quaternary Intraplate Deformation Defined by the Las Chacras Fault Zone, West‐Central Argentina
Authors: Rimando Jeremy M. , Schoenbohm Lindsay M. , Ortiz Gustavo , Alvarado Patricia , Venerdini Agostina , Owen Lewis A. , Seagren Erin G. , Figueiredo Paula Marques , J. Hammer Sarah 
Published: March 2021

AbstractSeveral major (up to MW7.5) earthquakes over the past 320 years have shaken the thick‐skinned Sierras Pampeanas region of Argentina, despite exhibiting much lower GPS‐shortening rates than across the thin‐skinned Precordillera region to its west. Whether geodetic shortening rates indicate an actual long‐term shortening gradient, and whether shortening rates translate to higher uplift rates due to steeper faults in the Sierras Pampeanas, remain uncertain due to the limited spatio‐temporal coverage and the inherently large error in the vertical component of deformation of GPS measurements. We measure geomorphic offsets and use10Be terrestrial cosmogenic nuclide surface exposure dating to determine slip rates on the Las Chacras Fault Zone (LCFZ)—an ∼30 km long, NNW‐trending, steeply dipping (55–65°E) reverse fault that branches off of the longest, westernmost, thick‐skinned Valle Fértil range‐front fault in the western Sierras Pampeanas. Average shortening and uplift rates measured on the LCFZ are ∼0.2 and ∼0.3–0.4 mm/yr, respectively. Despite an uplift rate similar to most other faults in the region, the LCFZ shortening rate is lower than faults to its west; this is in agreement with the inferred west‐east decrease in shortening rates from GPS data, indicating consistent regional deformation patterns since the Late Pleistocene. The decrease in shortening to the east coincides spatially with the termination of the flat portion of the subducted Nazca plate between 67 and 68°W. From scaling relationships among magnitude, slip rate, and fault length, the LCFZ is capable of generating earthquakes of MW6.7–7.1.
Tracing and Closing the Water Balance in a Vegetated Lysimeter
Authors: Benettin Paolo , Nehemy Magali F. , Asadollahi Mitra , Pratt Dyan , Bensimon Michaël , McDonnell Jeffrey J. , Rinaldo Andrea 
Published: March 2021

AbstractClosure of the soil water balance is fundamental to ecohydrology. But closing the soil water balance with hydrometric information offers no insight into the age distribution of water transiting the soil column via deep drainage or the combination of soil evaporation and transpiration. This is a major challenge in our discipline currently; tracing the water balance is the needed next step. Here we report results from a controlled tracer experiment aimed at both closing the soil water balance and tracing its individual components. This was carried out on a 2.5 m3lysimeter planted with a willow tree. We applied 25 mm of isotopically enriched water on top of the lysimeter and tracked it for 43 days through the soil water, the bottom drainage, and the plant xylem. We then destructively sampled the system to quantify the remaining isotope mass. More than 900 water samples were collected for stable isotope analysis to trace the labeled irrigation. We then used these data to quantify when and where the labeled irrigation became the source of plant uptake or deep percolation. Evapotranspiration dominated the water balance outflow (88%). Tracing the transpiration flux showed further that transpiration was soil water that had fallen as precipitation 1–2 months prior. The tracer breakthrough in transpiration was complex and different from the breakthrough curves observed within the soil or in the bottom drainage. Given the lack of direct experimental data on travel time to transpiration, these results provide a first balance closure where all the relevant outflows are traced.
ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E
Authors: Hernandez James D. , Li Ting , Rau Cassandra M. , LeSuer William E. , Wang Panwen , Coletta Dawn K. , Madura James A. , Jacobsen Elizabeth A. , De Filippis Eleanna 
Published: March 2021

Abstract
Background
Long chain omega-3 polyunsaturated fatty acids (ω-3PUFA) supplementation in animal models of diet-induced obesity has consistently shown to improve insulin sensitivity. The same is not always reported in human studies with insulin resistant (IR) subjects with obesity.

Objective
We studied whether high-dose ω-3PUFA supplementation for 3 months improves insulin sensitivity and adipose tissue (AT) inflammation in IR subjects with obesity.

Methods
Thirteen subjects (BMI = 39.3 ± 1.6 kg/m2) underwent 80 mU/m2·min euglycemic-hyperinsulinemic clamp with subcutaneous (Sc) AT biopsy before and after 3 months of ω-3PUFA (DHA and EPA, 4 g/daily) supplementation. Cytoadipokine plasma profiles were assessed before and after ω-3PUFA. AT-specific inflammatory gene expression was evaluated on Sc fat biopsies. Microarray analysis was performed on the fat biopsies collected during the program.

Results
Palmitic and stearic acid plasma levels were significantly reduced (P < 0.05) after ω-3PUFA. Gene expression of pro-inflammatory markers and adipokines were improved after ω-3PUFA (P < 0.05). Systemic inflammation was decreased after ω-3PUFA, as shown by cytokine assessment (P < 0.05). These changes were associated with a 25% increase in insulin-stimulated glucose disposal (4.7 ± 0.6 mg/kg ffm•min vs. 5.9 ± 0.9 mg/kg ffm•min) despite no change in body weight. Microarray analysis identified 53 probe sets significantly altered post- ω-3PUFA, with Apolipoprotein E (APOE) being one of the most upregulated genes.

Conclusion
High dose of long chain ω-3PUFA supplementation modulates significant changes in plasma fatty acid profile, AT, and systemic inflammation. These findings are associated with significant improvement of insulin-stimulated glucose disposal. Unbiased microarray analysis of Sc fat biopsy identified APOE as among the most differentially regulated gene after ω-3PUFA supplementation. We speculate that ω-3PUFA increases macrophage-derived APOE mRNA levels with anti-inflammatory properties.
Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior
Authors: Lichtman Daniela , Bergmann Eyal , Kavushansky Alexandra , Cohen Nadav , Levy Nina S. , Levy Andrew P. , Kahn Itamar 
Published: March 2021

AbstractIQSEC2 is an X-linked gene that is associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and is suggested to play a role in AMPA receptor trafficking and mediation of long-term depression. Here, we present brain-wide structural volumetric and functional connectivity characterization in a novel mouse model with a missense mutation in the IQ domain of IQSEC2 (A350V). Using high-resolution structural and functional MRI, we show that animals with the A350V mutation display increased whole-brain volume which was further found to be specific to the cerebral cortex and hippocampus. Moreover, using a data-driven approach we identify putative alterations in structure–function relations of the frontal, auditory, and visual networks in A350V mice. Examination of these alterations revealed an increase in functional connectivity between the anterior cingulate cortex and the dorsomedial striatum. We also show that corticostriatal functional connectivity is correlated with individual variability in social behavior only in A350V mice, as assessed using the three-chamber social preference test. Our results at the systems-level bridge the impact of previously reported changes in AMPA receptor trafficking to network-level disruption and impaired social behavior. Further, the A350V mouse model recapitulates similarly reported brain-wide changes in other ASD mouse models, with substantially different cellular-level pathologies that nonetheless result in similar brain-wide alterations, suggesting that novel therapeutic approaches in ASD that result in systems-level rescue will be relevant to IQSEC2 mutations.
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Authors: Albinger Nawid , Hartmann Jessica , Ullrich Evelyn 
Published: March 2021

AbstractChimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. Currently, more than 500 CAR-T and 17 CAR-NK cell trials are being conducted worldwide including the four CAR-T cell products Kymriah, Yescarta, Tecartus and Breyanzi, which are already available on the market. Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany.
The recombination landscape and multiple QTL mapping in a Solanum tuberosum cv. ‘Atlantic’-derived F1 population
Authors: da Silva Pereira Guilherme , Mollinari Marcelo , Schumann Mitchell J. , Clough Mark E. , Zeng Zhao-Bang , Yencho G. Craig 
Published: March 2021

AbstractThere are many challenges involved with the genetic analyses of autopolyploid species, such as the tetraploid potato,Solanum tuberosum(2n = 4x = 48). The development of new analytical methods has made it valuable to re-analyze an F1population (n = 156) derived from a cross involving ‘Atlantic’, a widely grown chipping variety in the USA. A fully integrated genetic map with 4285 single nucleotide polymorphisms, spanning 1630 cM, was constructed with MAPpoly software. We observed that bivalent configurations were the most abundant ones (51.0~72.4% depending on parent and linkage group), though multivalent configurations were also observed (2.2~39.2%). Seven traits were evaluated over four years (2006–8 and 2014) and quantitative trait loci (QTL) mapping was carried out using QTLpoly software. Based on a multiple-QTL model approach, we detected 21 QTL for 15 out of 27 trait-year combination phenotypes. A hotspot on linkage group 5 was identified with co-located QTL for maturity, plant yield, specific gravity, and internal heat necrosis resistance evaluated over different years. Additional QTL for specific gravity and dry matter were detected with maturity-corrected phenotypes. Among the genes around QTL peaks, we found those on chromosome 5 that have been previously implicated in maturity (StCDF1) and tuber formation (POTH1). These analyses have the potential to provide insights into the biology and breeding of tetraploid potato and other autopolyploid species.
A multiomics approach to identify host-microbe alterations associated with infection severity in diabetic foot infections: a pilot study
Authors: Radzieta Michael , Sadeghpour-Heravi Fatemah , Peters Timothy J. , Hu Honghua , Vickery Karen , Jeffries Thomas , Dickson Hugh G. , Schwarzer Saskia , Jensen Slade O. , Malone Matthew 
Published: March 2021

AbstractDiabetic foot infections (DFIs) are a major cause of hospitalization and can lead to lower extremity amputation. In this pilot study, we used a multiomics approach to explore the host–microbe complex within DFIs. We observed minimal differences in the overall microbial composition between PEDIS infection severities, however Staphylococcus aureus and Streptococcus genera were abundant and highly active in most mild to moderate DFIs. Further, we identified the significant enrichment of several virulence factors associated with infection pathogenicity belonging to both Staphylococcus aureus and Streptococcus. In severe DFIs, patients demonstrated a greater microbial diversity and differential gene expression demonstrated the enrichment of multispecies virulence genes suggestive of a complex polymicrobial infection. The host response in patients with severe DFIs was also significantly different as compared to mild to moderate DFIs. This was attributed to the enrichment of host genes associated with inflammation, acute phase response, cell stress and broad immune-related responses, while those associated with wound healing and myogenesis were significantly depleted.