bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing laser speckle reduction by decreasing the pitch of a chiral nematic liquid crystal diffuser
Authors: Hansford David J. , Jin Yihan , Elston Steve J. , Morris Stephen M. 
Published: March 2021

AbstractThe artefact known as speckle can plague numerous imaging applications where the narrow linewidth of laser light is required, which includes laser projection and medical imaging. Here, we report on the use of thin-film chiral nematic liquid crystal (LC) devices that can be used to mitigate the influence of speckle when subjected to an applied electric field. Results are presented which show that the speckle contrast (a quantitative measure of the presence of speckle) can be significantly reduced by decreasing the pitch of the chiral nematic LC from 2700 to 244 nm. Further reduction in the speckle contrast can be observed by operating the diffuser technology at a temperature close to the chiral nematic to isotropic transition. At such temperatures, we observe a simultaneous improvement in the transmission of light through the device and a decrease in the electric field amplitude required for the minimum speckle contrast value. We conclude by presenting a laser projected image of the 1951 USAF target with and without the LC device to demonstrate the visual improvement as a result of the speckle reduction.
Glial cell type-specific gene expression in the mouse cerebrum using the piggyBac system and in utero electroporation
Authors: Hamabe-Horiike Toshihide , Kawasaki Kanji , Sakashita Masataka , Ishizu Chihiro , Yoshizaki Tomokazu , Harada Shin-ichi , Ogawa-Ochiai Keiko , Shinmyo Yohei , Kawasaki Hiroshi 
Published: March 2021

AbstractGlial cells such as astrocytes and oligodendrocytes play crucial roles in the central nervous system. To investigate the molecular mechanisms underlying the development and the biological functions of glial cells, simple and rapid techniques for glial cell-specific genetic manipulation in the mouse cerebrum would be valuable. Here we uncovered that the Gfa2 promoter is suitable for selective gene expression in astrocytes when used with the piggyBac system and in utero electroporation. In contrast, the Blbp promoter, which has been used to induce astrocyte-specific gene expression in transgenic mice, did not result in astrocyte-specific gene expression. We also identified the Plp1 and Mbp promoters could be used with the piggyBac system and in utero electroporation to induce selective gene expression in oligodendrocytes. Furthermore, using our technique, neuron-astrocyte or neuron-oligodendrocyte interactions can be visualized by labeling neurons, astrocytes and oligodendrocytes differentially. Our study provides a fundamental basis for specific transgene expression in astrocytes and/or oligodendrocytes in the mouse cerebrum.
Long-term dynamics of plant communities after biological remediation of oil-contaminated soils in far north
Authors: Novakovskiy A. B. , Kanev V. A. , Markarova M. Y. 
Published: March 2021

AbstractWe studied the long-term dynamics of plant communities after bio and phytoremediation of oil-polluted soils. Nine plots located in European Northeast and treated using various bioremediation methods were monitored from 2002 to 2014. Geobotanical descriptions (relevés) of each plot were performed in 2006 and 2014, and Grime’s theoretical CSR (competition–stress–ruderality) framework was used to assess the vegetation state and dynamics. We observed a clear shift of communities from pioneer (where ruderal species were prevalent) to stable (where competitor species were dominant) states. However, the remediation type did not significantly impact the vegetation recovery rate. After 12 years, all methods led to a 55–90% decrease in the oil content of the soil and a recovery of the vegetation cover. The plant communities contained mainly cereals and sedges which significantly differed from the original tundra communities before the oil spill. The control plot, treated only by mechanical cleaning, had minimum oil degradation rate (50%) and vegetation recovery rates, although, in CSR terms, its vegetation assemblage resembled the background community. Cereals (Agrostis gigantea,Deschampsia cespitosa,Phalaris arundinacea, andPoa pratensis), sedges (Carex canescens,Carex limosa, andEriophorum vaginatum), and shrubs (Salix) were found to be the most effective species for phytoremediation, exhibiting high community productivity under the harsh northern conditions.
Investigating the relationship between the SNCA gene and cognitive abilities in idiopathic Parkinson’s disease using machine learning
Authors: Ramezani Mehrafarin , Mouches Pauline , Yoon Eunjin , Rajashekar Deepthi , Ruskey Jennifer A. , Leveille Etienne , Martens Kristina , Kibreab Mekale , Hammer Tracy , Kathol Iris , Maarouf Nadia , Sarna Justyna , Martino Davide , Pfeffer Gerald , Gan-Or Ziv , Forkert Nils D. , Monchi Oury 
Published: March 2021

AbstractCognitive impairments are prevalent in Parkinson’s disease (PD), but the underlying mechanisms of their development are unknown. In this study, we aimed to predict global cognition (GC) in PD with machine learning (ML) using structural neuroimaging, genetics and clinical and demographic characteristics. As a post-hoc analysis, we aimed to explore the connection between novel selected features and GC more precisely and to investigate whether this relationship is specific to GC or is driven by specific cognitive domains. 101 idiopathic PD patients had a cognitive assessment, structural MRI and blood draw. ML was performed on 102 input features including demographics, cortical thickness and subcortical measures, and several genetic variants (APOE,MAPT,SNCA, etc.). Using the combination of RRELIEFF and Support Vector Regression, 11 features were found to be predictive of GC including sex, rs894280, Edinburgh Handedness Inventory, UPDRS-III, education, five cortical thickness measures (R-parahippocampal, L-entorhinal, R-rostral anterior cingulate, L-middle temporal, and R-transverse temporal), and R-caudate volume. The rs894280 ofSNCAgene was selected as the most novel finding of ML. Post-hoc analysis revealed a robust association between rs894280 and GC, attention, and visuospatial abilities. This variant indicates a potential role for theSNCAgene in cognitive impairments of idiopathic PD.
The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
Authors: Kutuzov M. M. , Belousova E. A. , Kurgina T. A. , Ukraintsev A. A. , Vasil’eva I. A. , Khodyreva S. N. , Lavrik O. I. 
Published: March 2021

AbstractThe regulation of repair processes including base excision repair (BER) in the presence of DNA damage is implemented by a cellular signal: poly(ADP-ribosyl)ation (PARylation), which is catalysed by PARP1 and PARP2. Despite ample studies, it is far from clear how BER is regulated by PARPs and how the roles are distributed between the PARPs. Here, we investigated the effects of PARP1, PARP2 and PARylation on activities of the main BER enzymes (APE1, DNA polymerase β [Polβ] and DNA ligase IIIα [LigIIIα]) in combination with BER scaffold protein XRCC1 in the nucleosomal context. We constructed nucleosome core particles with midward- or outward-oriented damage. It was concluded that in most cases, the presence of PARP1 leads to the suppression of the activities of APE1, Polβ and to a lesser extent LigIIIα. PARylation by PARP1 attenuated this effect to various degrees depending on the enzyme. PARP2 had an influence predominantly on the last stage of BER: DNA sealing. Nonetheless, PARylation by PARP2 led to Polβ inhibition and to significant stimulation of LigIIIα activities in a NAD+-dependent manner. On the basis of the obtained and literature data, we suggest a hypothetical model of the contribution of PARP1 and PARP2 to BER.
The relationship between apathy and impulsivity in large population samples
Authors: Petitet Pierre , Scholl Jacqueline , Attaallah Bahaaeddin , Drew Daniel , Manohar Sanjay , Husain Masud 
Published: March 2021

AbstractApathy and impulsivity are debilitating conditions associated with many neuropsychiatric conditions, and expressed to variable degrees in healthy people. While some theories suggest that they lie at different ends of a continuum, others suggest their possible co-existence. Surprisingly little is known, however, about their empirical association in the general population. Here, gathering data from six large studies ($$n = 3755$$

n
=
3755

), we investigated the relationship between measures of apathy and impulsivity in young adults. The questionnaires included commonly used self-assessment tools—Apathy Evaluation Scale, Barratt Impulsiveness Scale (BIS-11) and UPPS-P Scale—as well as a more recent addition, the Apathy Motivation Index (AMI). Remarkably, across datasets and assessment tools, global measures of apathy and impulsivity correlated positively. However, analysis of sub-scale scores revealed a more complex relationship. Although most dimensions correlated positively with one another, there were two important exceptions revealed using the AMI scale. Social apathy was mostly negatively correlated with impulsive behaviour, and emotional apathy was orthogonal to all other sub-domains. These results suggest that at a global level, apathy and impulsivity do not exist at distinct ends of a continuum. Instead, paradoxically, they most often co-exist in young adults. Processes underlying social and emotional apathy, however, appear to be different and dissociable from behavioural apathy and impulsivity.
Kinetics of slow release of nitrogen fertiliser from multi-layered nanofibrous structures
Authors: Javazmi Leila , Young Anthony , Ash Gavin J. , Low Tobias 
Published: March 2021

AbstractFertilisers are essential in modern agriculture to enhance plant growth, crop production and product quality. Recent research has focused on the development of delivery systems designed to prolong fertiliser release. This study introduces a new technology to encapsulate and release molecules of fertilisers by using multi-layered electrospun nanofibre as a carrier. Single-layer poly L-lactic acid (PLLA) nanofibres loaded with urea were fabricated using electrospinning. Triple-layer nanofibrous structures were produced by electrospinning polyhydroxybutyrate (PHB) nanofibres as external layers with PLLA nanofibres impregnated with urea fertiliser as the middle layer. Scanning electron microscopy (SEM) and Fourier transform infrared spectrophotometry (FTIR) were employed to characterize the morphology of electrospun nanofibres. Urea release dynamic was analysed using a total nitrogen instrument (TNM-1). The results indicated that triple-layered urea-impregnated nanofibrous structures led to lower initial rate of nitrogen release and slower release rate of cumulative nitrogen which extended for more than three months. It is concluded that triple-layer nanofibrous structures have the potential for slow release delivery of fertilisers.
Comparison of two superconducting phases induced by a magnetic field in UTe2
Authors: Knafo W. , Nardone M. , Vališka M. , Zitouni A. , Lapertot G. , Aoki D. , Knebel G. , Braithwaite D. 
Published: March 2021

AbstractSuperconductivity induced by a magnetic field near metamagnetism is a striking manifestation of magnetically-mediated superconducting pairing. After being observed in itinerant ferromagnets, this phenomenon was recently reported in the orthorhombic paramagnet UTe2. Here we explore the phase diagram of UTe2 under two magnetic-field directions: the hard magnetization axis b, and a direction titled by ≃25-30° from b in the (b,c) plane. Zero-resistivity measurements confirm that superconductivity is established beyond the metamagnetic field Hm in the tilted-field direction. While superconductivity is locked exactly at fields either smaller (for H | | b), or larger (for H tilted by ≃27° from b to c), than Hm, the variations of the Fermi-liquid coefficient in the electrical resistivity and of the residual resistivity are similar for the two field directions. The resemblance of the normal states for the two field directions puts constraints for theoretical models of superconductivity and implies that some subtle ingredients must be in play.
Tunable exciton–polariton condensation in a two-dimensional Lieb lattice at room temperature
Authors: Scafirimuto Fabio , Urbonas Darius , Becker Michael A. , Scherf Ullrich , Mahrt Rainer F. , Stöferle Thilo 
Published: March 2021

AbstractMicrocavities with embedded optically active materials allow to create exciton–polariton condensates in the strong light–matter interaction regime. These condensates exhibit quantum fluid properties up to room temperature, and, when crystal-like lattices are imprinted in the cavity, they can be used to emulate and study solid-state physics toy models. Here, we demonstrate room temperature polariton condensation in a nano-fabricated two-dimensional Lieb lattice with an organic polymer. We exploit the tunability of our open cavity to selectively condense into the s-, p- and d-lattice band manifolds. Furthermore, we interferometrically measure long-range first-order coherence across the lattice and assess the influence of the disorder in the system. These are key first steps to investigate extended topological polariton systems at ambient conditions.
Atomic resolution imaging of cation ordering in niobium–tungsten complex oxides
Authors: Iijima Sumio , Yang Wenhui , Matsumura Syo , Ohnishi Ichiro 
Published: March 2021

AbstractEnergy dispersive X-ray emission imaging at atomic resolution is a powerful tool to solve order–disorder problems in complex metal oxide crystals, supplementing conventional X-ray or neutron diffraction. Here, we use this method, based on scanning transmission electron microscopy, to investigate cation ordering in ternary metal oxides 4Nb2O5·9WO3 and 2Nb2O5·7WO3, which have recently attracted attention as energy storage materials in lithium-ion batteries. Their crystal structures are a tetragonal tungsten bronze-type and its hybrid with a ReO3-type ‘block structure’, respectively. Our study reveals the presence of chemical ordering of metal ions in these materials, which have previously been assumed to be solid-solutions. In particular, we show that the two types of cations, Nb and W, are well ordered in their lattices, and that the Nb ions tend to occupy one third of the pentagonal channel sites. These results demonstrate that atomic resolution X-ray emission imaging is an effective alternative approach for the study of locally ordered crystal structures.
A caging strategy for tuning the magneto-optical properties of cobalt ferrite using a single plasmonic nanoparticle
Authors: Testa-Anta Martín , Sousa-Castillo Ana , López-Ortega Alberto , Correa-Duarte Miguel A. , García-Martín Antonio , Vavassori Paolo , Salgueiriño Verónica 
Published: March 2021

Investigations of the Faraday effect in silica capsules with numerous CoFe2O4 nanoparticles and one single gold nanoparticle demonstrate the plasmon-induced changes in the MOA of the ferrite and highlights the caging strategy designed.
Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation
Authors: Chen Xiao-Li , Xiao Qing-Ling , Pang Zhong-Hua , Tang Cheng , Zhu Qi-Yong 
Published: March 2021

Abstract
An-Chuan Granule (ACG), a traditional Chinese medicine (TCM) formula, is an effective treatment for asthma but its pharmacological mechanism remains poorly understood. In the present study, network pharmacology was applied to explore the potential mechanism of ACG in the treatment of asthma. The tumor necrosis factor (TNF), Toll-like receptor (TLR), and Th17 cell differentiation-related, nucleotide-binding oligomerization domain (NOD)-like receptor, and NF-kappaB pathways were identified as the most significant signaling pathways involved in the therapeutic effect of ACG on asthma. A mouse asthma model was established using ovalbumin (OVA) to verify the effect of ACG and the underlying mechanism. The results showed that ACG treatment not only attenuated the clinical symptoms, but also reduced inflammatory cell infiltration, mucus secretion and MUC5AC production in lung tissue of asthmatic mice. In addition, ACG treatment notably decreased the inflammatory cell numbers in bronchoalveolar lavage fluid (BALF) and the levels of pro-inflammatory cytokines (including IL-6, IL-17, IL-23, TNF-alpha, IL-1beta and TGF-beta) in lung tissue of asthmatic mice. In addition, ACG treatment remarkably down-regulated the expression of TLR4, p-P65, NLRP3, Caspase-1 and adenosquamous carcinoma (ASC) in lung tissue. Further, ACG treatment decreased the expression of receptor-related orphan receptor (RORγt) in lung tissue but increased that of Forkhead box (Foxp3). In conclusion, the above results demonstrate that ACG alleviates the severity of asthma in a ´multi-compound and multi-target’ manner, which provides a basis for better understanding of the application of ACG in the treatment of asthma.
The Effects of Symptom Onset Location on Automatic Amyotrophic Lateral Sclerosis Detection Using the Correlation Structure of Articulatory Movements
Authors: Wisler Alan , Teplansky Kristin , Heitzman Daragh , Wang Jun 
Published: March 2021

PurposeKinematic measurements of speech have demonstrated some success in automatic detection of early symptoms of amyotrophic lateral sclerosis (ALS). In this study, we examined how the region of symptom onset (bulbar vs. spinal) affects the ability of data-driven models to detect ALS.MethodWe used a correlation structure of articulatory movements combined with a machine learning model (i.e., artificial neural network) to detect differences between people with ALS and healthy controls. The performance of this system was evaluated separately for participants with bulbar onset and spinal onset to examine how region of onset affects classification performance. We then performed a regression analysis to examine how different severity measures and region of onset affects model performance.ResultsThe proposed model was significantly more accurate in classifying the bulbar-onset participants, achieving an area under the curve of 0.809 relative to the 0.674 achieved for spinal-onset participants. The regression analysis, however, found that differences in classifier performance across participants were better explained by their speech performance (intelligible speaking rate), and no significant differences were observed based on region of onset when intelligible speaking rate was accounted for.ConclusionsAlthough we found a significant difference in the model's ability to detect ALS depending on the region of onset, this disparity can be primarily explained by observable differences in speech motor symptoms. Thus, when the severity of speech symptoms (e.g., intelligible speaking rate) was accounted for, symptom onset location did not affect the proposed computational model's ability to detect ALS.
Quo vadis, European Space Weather community?
Authors: Lilensten Jean , Dumbović Mateja , Spogli Luca , Belehaki Anna , Van der Linden Ronald , Poedts Stefaan , Barata Teresa , Bisi Mario M. , Cessateur Gaël , De Donder Erwin , Guerrero Antonio , Kilpua Emilia , Korsos Marianna B. , Pinto Rui F. , Temmer Manuela , Tsagouri Ioanna , Urbář Jaroslav , Zuccarello Francesca 
Published: March 2021

This paper was written by a group of European researchers believing that now is the right time to frame the Space Weather and Space Climate discipline in Europe for future years. It is devoted to openly discussing the organisation and sustainability of the European Space Weather community and its assets in the (near) future. More specifically, we suggest that the European Space Weather community lacks a uniting organisation to help the community to sustain and develop the successful efforts made thus far. Our aim is not to draw a complete and exhaustive panorama of Space Weather throughout the world, nor even throughout Europe. It is not a new white paper on the science and applications: there exist many (e.g. Tsurutani et al., 2020 Nonlinear Processes Geophys 27(1): 75–119); nor another roadmap: several important have been published recently (e.g. Schrijver et al., 2015. Adv Space Res 55(12): 2745–2807; Opgenoorth et al., 2019. J Space Weather Space Clim 9: A37). Our aim is to question our practices and organisation in front of several changes that have occurred in the recent years and to set the ground to provide coordinated answers to these questions being posed in Europe, and to make these answers discussed throughout the world.
This group was assembled first through a series of sessions devoted to the sustainability of Space Weather research during the European Space Weather Week (ESWW) series of meetings, specifically: ESWW 14 (2017), ESWW 15 (2018), and ESWW 16 (2019). It then grew from discussions and personal contacts. The authors do not pretend to identify the full range of opinions in Europe, although they do come from 13 different European countries with a large span of ages (around half are below the age of 40 years old at the time of writing) with a good gender balance ending with a diverse mix of young and motivated scientists and senior people who have played a role in shaping the Space Weather community in Europe. The questions and the propositions to organise Space Weather in Europe in the future result from their discussions through these meetings and through remote meetings during the pandemic. We wish to share them with all those who consider themselves as members of the European Space Weather community and/or are interested in its future and to propose actions. We do this, bearing in mind that Europe plays a key international role in Space Weather which extends beyond the ESA and EU/EC geographic area.
Arthroplasty of the Knee: Current Techniques for Implant Alignment
Authors: Weber Patrick , Gollwitzer Hans 
Published: March 2021

AbstractWhen a total knee arthroplasty (TKA) is implanted using the traditional mechanical alignment technique, this typically results in a straight leg, independently of pre-operative or even pre-arthrotic varus or valgus alignment. With mechanical alignment, we distinguish between 2 different alignment techniques: ligament balancing and bony referencing according to bony skeletal landmarks. In ligament balanced technique beside the straight mechanical axis, the prosthesis is implanted at 90° to the latter. The rotational alignment of the femur is set according to the ligament tension. In the skeletal referenced technique, the rotation of the femur is also set according to bony skeletal landmarks. As a variation of this technique, the prosthesis can be implanted with anatomical alignment. In this technique, the medial slope of the joint line of 3° in the frontal plane is respected during the implantation of TKA. Both techniques result in comparable long-term results with
survival rates of almost 80% after 25 years. On the other hand, 15 – 20% of TKA patients report dissatisfaction with their clinical result. For more than 10 years now, the kinematic TKA alignment concept has been developed with the goal to achieve implantation that is adapted to the individual anatomy of the patient. The advocates of this technique expect better function of TKA. This strategy aims to reconstruct the pre-arthrotic anatomy of a given patient while preserving the existing joint line and the mechanical axis without performing ligamentary release. Studies have shown that the function of the prothesis is at least that good as in the conventional techniques. Long-term results are still sparse, but initial studies show that TKA implanted using the kinematic alignment technique exhibit comparable 10-year-survival rates to those implanted using the traditional mechanical alignment technique. Future studies need to show the limitations of this new technique and to
identify patients who will or will not significantly benefit from this technique.