bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
Authors: Middelkamp Maximilian , Ruck Lisa , Krisp Christoph , Sumisławski Piotr , Mohammadi Behnam , Dottermusch Matthias , Meister Valerie , Küster Lukas , Schlüter Hartmut , Windhorst Sabine , Neumann Julia E. 
Published: November 2021

AbstractLIN28A overexpression has been identified in malignant brain tumors called embryonal tumors with multilayered rosettes (ETMR) but its specific role during brain development remains largely unknown. Radial glia cells of the ventricular zone (VZ) are proposed as a cell of origin for ETMR. We asked whether an overexpression of LIN28A in such cells might affect brain development or result in the formation of brain tumors.Constitutive overexpression of LIN28A in hGFAP-cre::lsl-Lin28A (GL) mice led to a transient increase of proliferation in the cortical VZ at embryonic stages but no postnatal brain tumor formation. Postnatally, GL mice displayed a pyramidal cell layer dispersion of the hippocampus and altered spine and dendrite morphology, including reduced dendritic spine densities in the hippocampus and cortex. GL mice displayed hyperkinetic activity and differential quantitative MS-based proteomics revealed altered time dependent molecular functions regarding mRNA processing and spine morphogenesis. Phosphoproteomic analyses indicated a downregulation of mTOR pathway modulated proteins such as Map1b being involved in microtubule dynamics.In conclusion, we show that Lin28A overexpression transiently increases proliferation of neural precursor cells but it is not sufficient to drive brain tumors in vivo. In contrast, Lin28A impacts on protein abundancy patterns related to spine morphogenesis and phosphorylation levels of proteins involved in microtubule dynamics, resulting in decreased spine densities of neurons in the hippocampus and cortex as well as in altered behavior. Our work provides new insights into the role of LIN28A for neuronal morphogenesis and development and may reveal future targets for treatment of ETMR patients.
How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention
Authors: Luciano Mario , Sampogna Gaia , Amore Mario , Andriola Ileana , Calcagno Pietro , Carmassi Claudia , Del Vecchio Valeria , Dell’Osso Liliana , Di Lorenzo Giorgio , Gelao Barbara , Giallonardo Vincenzo , Rossi Alessandro , Rossi Rodolfo , Siracusano Alberto , Fiorillo Andrea ,   LIFESTYLE Working Group
Published: November 2021

Abstract

Background

People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, with a decade of years of life lost. In this randomized controlled trial (RCT), we assessed in a sample of people with bipolar disorder, major depressive disorder, and schizophrenia spectrum disorder, the efficacy of an innovative psychosocial group intervention compared to a brief psychoeducational group intervention on patients’ body mass index (BMI), body weight, waist circumference, Framingham and HOMA-IR indexes.

Methods

This is a multicentric RCT with blinded outcome assessments carried out in six Italian university centers. After recruitment patients were randomized to receive a 6-month psychosocial intervention to improve patients’ physical health or a brief psychoeducational intervention. All recruited patients were assessed with standardized assessment instruments at baseline and after 6 months. Anthropometric parameters and blood samples have also been collected.

Results

Four-hundred and two patients with a diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were randomly allocated to the experimental (N = 206) or the control group (N = 195). After 6 months, patients from the experimental group reported a significant reduction in BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31–2.84; p < 0.001), body weight (OR = 4.78, 95% CI: 0.80–28.27, p < 0.05), and waist circumference (OR = 5.43, 95% CI: 1.45–20.30, p < 0.05). Participants with impaired cognitive and psychosocial functioning had a worse response to the intervention.

Conclusions

The experimental group intervention was effective in improving the physical health in SMI patients. Further studies are needed to evaluate the feasibility of this intervention in real-world settings.
Weighted Vest Use to Improve Movement Control during Walking in Children with Autism
Authors: Harry John R. , Eggleston Jeffrey D. , Lidstone Daniel E. , Dufek Janet S. 
Published: November 2021

ABSTRACT
Weighted vests (WV) are used to influence behavior through sensory integration in children with autism spectrum disorder (ASD). However, WV effects on motor ability during walking are not well understood in this population despite the growing acceptance that motor impairment is a prominent feature of ASD. This study aimed to evaluate the effects of a WV (15% body mass) on spatial–temporal parameters and the control of the center of mass and the hip, knee, and ankle joints in children with ASD during walking using group and single-subject analyses. Eight male children (11 ± 4 yr, 1.45 ± 0.25 m, 55.28 ± 26.20 kg) with ASD walked overground with and without a WV while three-dimensional kinematic data were obtained. A two-way ANOVA and a model statistic technique (α = 0.05) were used to test for group and single-subject differences, respectively, for stride length, stride time, and smoothness of the center of mass and hip, knee, and ankle joint rotations. At the group level, stride length decreased (P = 0.018) in response to the WV perturbation, although no other differences were detected for any other variable. At the single-subject level, numerous differences (P < 0.05) were detected for each variable, although the differences detected were unique to each individual. WV use can alter gross movement function and body control during walking in some children with ASD. We suggest researchers and clinicians interested in evaluating WV use as a therapeutic modality to mitigate motor impairment in children with ASD proceed at the individual level to reveal individual responses to a WV intervention.
Optimal Management of Evolving Hierarchies
Authors: Hougaard Jens Leth , Moreno-Ternero Juan D. , Østerdal Lars Peter 
Published: November 2021

We study the optimal management of evolving hierarchies of revenue-generating agents. The initiator invests into expanding the hierarchy by adding another agent, who will bring revenues to the joint venture and who will invest herself into expanding the hierarchy further, and so on. The higher the investments (which are private information), the higher the probability of expanding the hierarchy. An allocation scheme specifies how revenues are distributed, as the hierarchy evolves. We obtain schemes that are socially optimal and initiator-optimal, respectively. Our results have potential applications for blockchain, cryptocurrencies, social mobilization, and multilevel marketing. This paper was accepted by Manel Baucells, behavioral economics and decision analysis.
Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway
Authors: Anderson Emily , Green Richard , Swift Andrew , Semple Malcolm G 
Published: November 2021

Hereditary haemorrhagic telangiectasia is a rare, genetic disorder that can present at any age. It is characterised by epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations, which can affect multiple organs. Early diagnosis and management reduces the morbidity and mortality associated with the disease.There is a well-established hereditary haemorrhagic telangiectasia clinic in London, and excellent links across Europe via the European Reference Network. However, local coordinated care for patients with hereditary haemorrhagic telangiectasia across the UK can be variable and often absent for children and young people. Some patients travel long distances to receive care in London, while others are referred to local clinicians or lost to follow up entirely.This article presents the experience to date from two regional UK centres (Liverpool and Dundee) where care for patients with hereditary haemorrhagic telangiectasia is being coordinated and streamlined. While there is still a lot to learn, this article highlights some of the successes and challenges identified so far, with suggestions for how these could be addressed.Collaborative regional networks such as these can facilitate the sharing of best practice and ensure that all patients with hereditary haemorrhagic telangiectasia are able to access safe, high-quality care.
Towards the Importance of the Type of Deep Neural Network and Employment of Pre-trained Word Vectors for Toxicity Detection: An Experimental Study
Authors: Kabakus Abdullah Talha 
Published: November 2021

As a natural consequence of offering many advantages to their users, social media platforms have become a part of daily lives. Recent studies emphasize the necessity of an automated way of detecting the offensive posts in social media since these ‘toxic’ posts have become pervasive. To this end, a novel toxic post detection approach based on Deep Neural Networks was proposed within this study. Given that several word embedding methods exist, we shed light on which word embedding method produces better results when employed with the five most common types of deep neural networks, namely, , , , , and a combination of and . To this end, the word vectors for the given comments were obtained through four different methods, namely, () , () , () , and () the layer of deep neural networks. Eventually, a total of twenty benchmark models were proposed and both trained and evaluated on a gold standard dataset which consists of tweets. According to the experimental result, the best , , was obtained on the proposed model without employing pre-trained word vectors which outperformed the state-of-the-art works and implies the effective embedding ability of s. Other key findings obtained through the conducted experiments are that the models, that constructed word embeddings through the layers, obtained higher s and converged much faster than the models that utilized pre-trained word vectors.
Development of a self-management intervention for stroke survivors with aphasia using co-production and behaviour change theory: An outline of methods and processes
Authors: Wray Faye , Clarke David , Cruice Madeline , Forster Anne 
Published: November 2021

Background
Self-management is a promising approach to improve quality of life after stroke. However, evidence for the appropriateness and effectiveness of self-management for stroke survivors with aphasia is limited. This article reports on the process used to develop a supported self-management intervention for stroke survivors with aphasia (SSWA) using co-production and behaviour change theory. Preparatory research included systematic reviews, and qualitative interviews and focus groups with SSWA, family members and speech and language therapists (SLTs).

Materials and methods
We conducted six, 2 hour long intervention development workshops with key stakeholders. The workshops were informed by principles of co-production and the intervention development process outlined by the Behaviour Change Wheel (BCW). We also incorporated the findings of our preparatory research within workshops. Each workshop included an introduction, 1–2 co-production tasks and time for feedback at the end of the session. Data were analysed on an ongoing basis so that findings could be used to feed in to subsequent workshops and intervention development.

Results
Workshop participants (n = 12) included; SSWA (n = 5), family members (n = 3) and SLTs (n = 4). Together, participants engaged with accessible and participatory co-production tasks which aligned with the BCW framework. Participants engaged in discussion to define self-management in behavioural terms (behavioural diagnosis) and to identify what needed to change to support self-management. Participant’s co-produced solutions for supporting self-management and discussed options to implement these in practice. Prototype materials were generated by the research team and evaluated by participants. Intervention functions and behaviour change techniques (BCTs) were mapped to the solutions generated by participants by the research team, after the final workshop. A supported self-management intervention for SSWA was developed which will be delivered by SLTs through community stroke services.

Conclusions
This paper reports the process we used to integrate co-production work with behaviour change theory to develop a complex self-management intervention. This is of relevance for researchers looking to harness the strengths of co-production methods and theory in intervention design. Future research will feasibility test the supported self-management intervention developed. This paper provides transparency to our intervention development process which will help others to better interpret the findings of our feasibility work.
Variations in greenhouse gas emissions of individual diets: Associations between the greenhouse gas emissions and nutrient intake in the United Kingdom
Authors: Rippin Holly L. , Cade Janet E. , Berrang-Ford Lea , Benton Tim G. , Hancock Neil , Greenwood Darren C. 
Published: November 2021

BackgroundFood production accounts for 30% of global greenhouse gas (GHG) emissions. Less environmentally sustainable diets are also often more processed, energy-dense and nutrient-poor. To date, the environmental impact of diets have mostly been based on a limited number of broad food groups.ObjectivesWe link GHG emissions to over 3000 foods, assessing associations between individuals’ GHG emissions, their nutrient requirements and their demographic characteristics. We also identify additional information required in dietary assessment to generate more accurate environmental impact data for individual-level diets.MethodsGHG emissions of individual foods, including process stages prior to retail, were added to the UK Composition Of Foods Integrated Dataset (COFID) composition tables and linked to automated online dietary assessment for 212 adults over three 24-hour periods. Variations in GHG emissions were explored by dietary pattern, demographic characteristics and World Health Organization Recommended Nutrient Intakes (RNIs).ResultsGHG emissions estimates were linked to 98% (n = 3233) of food items. Meat explained 32% of diet-related GHG emissions; 15% from drinks; 14% from dairy; and 8% from cakes, biscuits and confectionery. Non-vegetarian diets had GHG emissions 59% (95% CI 18%, 115%) higher than vegetarian. Men had 41% (20%, 64%) higher GHG emissions than women. Individuals meeting RNIs for saturated fats, carbohydrates and sodium had lower GHG emissions compared to those exceeding the RNI.DiscussionPolicies encouraging sustainable diets should focus on plant-based diets. Substituting tea, coffee and alcohol with more sustainable alternatives, whilst reducing less nutritious sweet snacks, presents further opportunities. Healthier diets had lower GHG emissions, demonstrating consistency between planetary and personal health. Further detail could be gained from incorporating brand, production methods, post-retail emissions, country of origin, and additional environmental impact indicators.
RAMPO NOIR : Proses Alih Wahana Cerpen “Kagami Jikoku” Karya Edogawa Rampo
Authors: Rahmah Yuliani , Meinati Dwi 
Published: November 2021

Penelitian ini merupakan penelitian lanjutan pada cerpem Kagami Jikoku,sebuah cerpen terkenal yang ditulis oleh Edogawa Rampou. Setelah dilakukan penelitian terhadap struktur cerpen tersebut, penelitian lanjutan dilakukan untuk menganalisis proses-proses alih wahana yang terjadi dari cerpen Kagami Jigoku ke dalam film Rampo Noir. Dengan menggunakan metode deskriptif kualitatif analisis proses alih wahana dilakukan pada unsur pembangun ceritanya. Sebagai hasilnya diketahui bahwa proses ekranisasi yang terjadi pada cerpen ke dalam film mencakup seluruh perubahan yang meliputi perubahan bervariasi, penambahan, dan penciutan. Unsur-unsur pembangun cerita yang mengalami seluruh proses ekranisasi adalah unsur tokoh, latar, dan alur. Unsur tokoh dan alur mengalami seluruh proses ekranisasi sementara unsur latar hanya mengalami proses penambahan dan perubahan bervariasi tanpa adanya penciutan. Dari proses tersebut diketahui pula bahwa pendekatan adaptasi yang digunakan dalam proses alih wahana ini adalah loose, karena meskipun cerita pada kedua media tersebut berbeda karena mengalami penyesuaian tetapi ide cerita dari cerita aslinya tetap dijaga.
Development of a CFD-based simulation model and optimization of thermal diffusion column: application on noble gas separation
Authors: Eghbalahmadi Hamed , Khadiv-Parsi Parissa , Mousavian Seyed Mohammad Ali , Eghbal Ahmadi Mohammad Hosein 
Published: November 2021

Abstract
In this study, numerical simulations were carried out to investigate the separation of the helium-argon gas mixture by thermal diffusion column. This research determined the significant parameters and their effects on the process performance. Effects of feed flow rate, cut ratio, and hot wire temperature in a 950 mm height column with an inner tube of 9.5 mm radius were examined through the simulation of the thermal diffusion column. For minimizing the number of simulations and obtaining the optimum operating conditions, response surface methodology (RSM) was used. Analysis of separative work unit (SWU) values as a target function for helium-argon separation clearly showed that the maximum amount of SWU in thermal diffusion column was achieved, when hot wire temperature increased as large as technically possible, and the feed rate and cut ratio were equal to 55 Standard Cubic Centimeters per Minute (SCCM) and 0.44, respectively. Finally, the SWU value in optimum conditions was compared with the experimental data. Results illustrated that the experimental data were in good agreement with simulation data with an accuracy of about 90%.
Pedestrian fatality risk as a function of tram impact speed
Authors: Gaca Stanislaw , Franek Lukasz 
Published: November 2021

Abstract
The objective of the presented research-work was to develop a model to describe the risk of fatal accident involving tram and pedestrian. This study extends research concerning relationships between the “impact speed” and probability of pedestrian death in case of tram accident. Over 400 “tram-pedestrian” accidents were analyzed. Logistic regression analysis was used in these studies. The main objective of the research is to compare the risk of fatal accidents when pedestrians are struck by passenger cars and trams. GPS system from trams is used to analyze correlation between the tram speed and different conditions along the public transport stop areas (e.g. traffic signals, priority, and platforms localization). The results show that the fatal risk of hitting pedestrians by a tram running at a speed of 50 km/h is two and a half times greater than that by a car. Research clearly proves that comparing to car impact speed, there is much higher probability of death when pedestrian is hit by a tram running at a speed of 30 km/h – almost 40% (compared to 5% when hit by car). There are even cases of deaths with a very low speed of tram (5–10 km/h).
A pair of rational double sequences
Authors: Altynbek Serik , Begehr Heinrich 
Published: November 2021

Abstract
Double sequences appear in a natural way in cases of iteratively given sequences if the iteration allows to determine besides the successors from the predecessors also the predecessors from their followers.
A particular pair of double sequences is considered which appears in a parqueting-reflection process of the complex plane.
While one end of each sequence is a natural number sequence, the other consists of rational numbers.
The natural numbers sequences are not yet listed in OEIS Wiki.
Complex versions from the double sequences are provided.
“Some people work a bit more than me, and so we tease them”: the production of an elite student community in an elite French higher education institution
Authors: Birolini Christophe 
Published: November 2021

AbstractThis article presents the results of an ethnographic study of student humor in a French elite higher education institution, specifically how students in the student community use the termpolard. The data was collected between 2014 and 2018 in one of France’s most prestigious elite higher education institution. There are two main ways this term is used as humor, indirectly mocking students, notably those outside the student community, a practice that constructs thepolardas a foil figure of a student who spends all their time doing schoolwork and refrains from participating in extracurricular activities, and teasing friends and acquaintances in interactions following a devalued behavior, seeming over-concerned with studies. Furthermore, there exist interactional scripts students can use to successfully navigate these teasing interactions without losing face. Finally, this humor is discussed in relation to the elite setting, as it is linked to the social closure of these elite higher education institutions, and it contributes to the production of an elite student community, by socializing students to privileged self-presentations characterized by ease and by creating distinctions between students, separating the truly elite students from the others.
Analysis of beta globin gene mutations in Diyarbakir
Authors: Tekeş Selahaddin , Oral Diclehan , Söker Murat , Şimşek Selda , Uzel Veysiye Hülya , Çürük Mehmet Akif 
Published: November 2021

Abstract

Objectives
Hemoglobin disorders are quite heterogeneous in the Turkish population. Up to now, more than forty different beta thalassemia mutations and 60 hemoglobin variants have been characterized in the country. The aim of this study was to investigate genetic heterogeneity of HBB gene mutations in patients and their parents at Southeastern Anatolia in Turkey.

Methods
Genomic DNA was isolated from 145 thalassemic patients’ blood samples and their parents in this study. Ten different HBB gene mutations HBB:c.-80T>A, HBB:c.17_18delCT, HBB:c.25_26delAA, HBB:c.92+1G>A, HBB:c.92+5G>C, HBB:c.92+6T>C, HBB:c.93-21G>A, HBB:c.135delC, HBB:c.315+1G>A, HBB:c.316-106C>G were screened by amplification refractory mutation system. Four Hb variants and some rare beta thalassemia mutation were characterized by DNA sequencing.

Results
In this study, 97 homozygous and 48 compound heterozygous thalassemic patients were diagnosed by molecular genetic analyses. As a results, 18 β-thalassemia mutations and four abnormal hemoglobins; HBB:c.20A>T, HBB:c.364G>C, HBB:c.34G>A and HBB:c.208G>A were detected at Dicle University Hospital.

Conclusions
In the results, HBB:c.93-21G>A is the most common mutation in the region. Three mutations [(HBB:c.93-21G>A), (HBB:c.25_26delAA) and (HBB:c.135delC)] account for about 58 per cent of all the point mutations. Except HBB:c.20A>T and HBB:c.364G>C, two silent Hb variants (HBB:c.34G>A and HBB:c.208G>A) were detected in this study. Hb Hamilton [β11 (GTT>ATT) Val>Ile] was seen first time in Turkey.
The Excerpt Tablets of Šumma ālu: Reconstructing Tablets 80 to 95
Authors: Boddy Kaira , Huber Vulliet Fabienne , Mittermayer Catherine 
Published: November 2021

Abstract
Our knowledge about the omen series šumma ālu ina mēlê šakin has much advanced since the first manuscripts were edited. Even though the overall structure of Šumma ālu is generally well established, the final third of the series still poses considerable problems. In this article we will present a new reconstruction for the sequence from Tablet 80 to 95. As colophons with catchlines and Tablet numbers are scarce for this part of the series, we have developed a new method for the reconstruction mainly relying on clusters of excerpt tablets originating from Nineveh.