bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re‐establishing needed limits: European competition policy's role in European healthcare systems and the lessons of the Dôvera case
Authors: Morton Andrew J. B. 
Published: November 2021

AbstractEuropean competition policy's first interactions with national healthcare systems emerged after 2000 without much controversy as only those healthcare regimes with clear market‐orientated elements were subject to EU competition rules. After 2010 however, this began to be challenged as a result of pressures from the private sector, various marketization reforms in Europe as well as pressures from within the EU itself. The question therefore re‐emerged: would EU competition law, and its ‘state aid law’ part especially, now be pushed into social solidarity‐orientated healthcare, including those that were subject to some degree of marketisation? This article examines this question through two important recent competition law cases from Belgium and Slovakia, but with a focus on the latter. Despite the apparent limits placed on European competition law's place in healthcare in the 2000s, European Commission and the Court of Justice were called upon to reassert some limits on its role in healthcare and social solidarity‐based regimes in particular. Together, the Iris‐H and Dôvera cases resolve those political and institutional problems that such a competition policy‐based intrusion into healthcare would have created.
Did Brett Kavanaugh's overt partisanship cause severe harm to the legitimacy of the U.S. Supreme Court?
Authors: Zigerell L. J. 
Published: November 2021

AbstractObjectiveCarrington and French (2021) claimed that “our findings suggest that, when a nominee [to the U.S. Supreme Court] behaves in an overtly partisan manner, it can cause severe harm to the legitimacy of the Court by increasing support for efforts to rein in the Court's authority and independence” (p. 1485). The evidence reported in Carrington and French (2021) for this claim is assessed.MethodThe research designs in Carrington and French (2021) are discussed, and further statistical analyses are reported.ResultsThe research designs in Carrington and French (2021) cannot support the aforementioned key claim of Carrington and French (2021).ConclusionsCarrington and French (2021) do not support the claim that the behavior of Brett Kavanaugh during his confirmation hearings severely harmed the legitimacy of the U.S. Supreme Court on net among the U.S. public.
Exhaustivity and homogeneity effects with distributive‐share markers: Experimental evidence from Serbian po
Authors: Bosnić Ana , Demirdache Hamida , Spenader Jennifer 
Published: November 2021

AbstractThere are two competing approaches to the semantics of distributive‐share markers: they are either universal distributive quantifiers over events or are merely event‐plurality markers. To address this debate, we present new conclusions based on novel experiments with Serbian transitive sentences in which the distributive‐share marker po was attached to the direct object. The first two experiments investigated exhaustivity effects in transitive sentences with po, while the third experiment probed homogeneity effects across three types of negative transitive sentences: with po marking the object, with the distributive‐key quantifier svaki (‘every’) in subject position, and with neither. If po is a universal quantifier, then it should enforce exhaustive distribution over a distributive key and remove homogeneity effects in negative sentences with a definite subject. If instead po is an event‐plurality marker with no universal quantificational force, then it should neither enforce exhaustive distribution nor remove homogeneity effects in negative sentences with a definite subject. We conclude that there are two populations of Serbian speakers with systematic patterns of interpretation: one population interprets po as a universal quantifier and one population interprets po as an event‐plurality marker. We conjecture that this population split might reflect an ongoing diachronic change in the semantic import of the distributive‐share marker po.
Shifting states of love and intimacy
Authors: Hoogenraad Henrike , Dundon Alison 
Published: November 2021

AbstractLove and intimacy are personal as well as political; they are concepts that are multidimensional, complex, and, sometimes, contradictory; and are meaningful to institutions and states as well as individuals. Dynamic local and global forces generate shifts in perceptions and experiences of intimacy and love, which are mediated by a wide variety of actors, ideals, beliefs and practices. This introduction to the special issue of shifting states of love, intimacy and intimate citizenship explores how these experiences are shaped by political, sociocultural, legal and intimate borders and boundaries, both literal and metaphorical. The article points to intimate relationships that, in various ways, challenge or transgress normative boundaries, but which are simultaneously experienced as empowering and deeply meaningful to those involved. This introduction to the special issue, as a collection of ethnographically rich analyses of loving, proffers new insights into the emergence of various forms of intimacies: from love across state borders, polygamous intimacies, transnational, intercultural and online love and dating, to interspecies intimacies based on mutual love and care.
MSI1 and HDA6 function interdependently to control flowering time via chromatin modifications
Authors: Xu Yingchao , Li Qing , Yuan Lianyu , Huang Yisui , Hung Fu‐Yu , Wu Keqiang , Yang Songguang 
Published: November 2021

SUMMARYMULTICOPY SUPPRESSOR OF IRA1 (MSI1) is a conserved subunit of Polycomb Repressive Complex 2 (PRC2), which mediates gene silencing by histone H3 lysine 27 trimethylation (H3K27Me3). Here, we demonstrated that MSI1 interacts with the RPD3‐like histone deacetylase HDA6 both in vitro and in vivo. MSI1 and HDA6 are involved in flowering and repress the expression of FLC, MAF4, and MAF5 by removing H3K9 acetylation but adding H3K27Me3. Chromatin immunoprecipitation analysis showed that HDA6 and MSI1 interdependently bind to the chromatin of FLC, MAF4, and MAF5. Furthermore, H3K9 deacetylation mediated by HDA6 is dependent on MSI1, while H3K27Me3 mediated by PRC2 containing MSI1 is also dependent on HDA6. Taken together, these data indicate that MSI1 and HDA6 act interdependently to repress the expression of FLC, MAF4, and MAF5 through histone modifications. Our findings reveal that the HDA6–MSI1 module mediates the interaction between histone H3 deacetylation and H3K27Me3 to repress gene expression involved in flowering time control.
Comparison of the prevalence of Domestic Cat Hepadnavirus in a population of cats with uveitis and in a healthy blood donor cat population in the United Kingdom
Authors: Jeanes Emily C. , Wegg Michaela L. , Mitchell Judy A. , Priestnall Simon L. , Fleming Lorraine , Dawson Charlotte 
Published: November 2021

AbstractObjectiveDomestic Cat Hepadnavirus (DCH) is a novel virus recently identified in the domestic cat. Currently, little is known regarding its clinical significance. The hepadnaviridae family includes the Hepatitis B Virus (HBV). Co‐infection of HBV and Hepatitis C in humans increases the risk of uveitis. We aimed to determine whether DCH is present in the United Kingdom (UK) and whether DCH warrants investigation as a potential cause of uveitis in cats.ProceduresClinical records from the Royal Veterinary College (RVC) and the Animal Health Trust (AHT) were reviewed for feline cases diagnosed with endogenous uveitis. A healthy control group was identified from cats presented to the RVC as blood donors. DNA was extracted from stored blood samples using commercially available kits. Polymerase chain reaction assays were performed to confirm the presence of feline DNA and to detect the presence of DCH DNA using previously described protocols.ResultsBlood samples were available from 65 cats with endogenous uveitis and 43 healthy control cats. Two blood samples from cats with endogenous uveitis tested positive for the presence of DCH DNA. DCH DNA was not detected in the control group. There was no statistically significant difference between the prevalence of DCH between the groups.ConclusionsDomestic Cat Hepadnavirus is present in the UK. This study failed to demonstrate a conclusive link between DCH and uveitis in cats, although further studies to investigate an association with other feline diseases are warranted.
An unusual case of eosinophilic uveitis in a cat
Authors: Newbold Georgina M. , Premanandan Chris 
Published: November 2021

AbstractAn 8‐year‐old female spayed domestic short‐haired cat was examined for recurrent unilateral anterior uveitis of 5 month's duration. No underlying cause was found on infectious disease screening. The cat also had a 4‐year history of allergic or immune‐mediated skin disease that was controlled with corticosteroid injections followed by long‐term oral cyclosporine therapy. Medical management with frequent topical anti‐inflammatory drugs (prednisolone acetate 1% suspension, diclofenac 0.1% solution) controlled the intraocular inflammation; however, the uveitis would relapse when therapy was discontinued. Eventually, secondary glaucoma developed OD and the eye was enucleated. At the time of surgery, a complete blood count showed a mild eosinophilia. Histopathology revealed a marked panuveitis characterized by an abundant accumulation of mixed inflammatory cells, with a predominantly eosinophilic infiltrate in the anterior chamber, iris, ciliary body, and choroid. No etiologic agents were found on serial sections, and there were no cellular criteria for malignancy noted. Nine months after enucleation, the chronic dermatitis appeared to be in remission despite no further medical management. This is the first known report of a primarily eosinophilic uveitis in a cat with chronic allergic skin disease and may be considered an ocular variant of feline eosinophilic granuloma complex.
Combination of Aerobic Training and Cocoa Flavanols as Effective Therapies to Reduce Metabolic and Inflammatory Disruptions in Insulin-Resistant Rats: The Exercise, Cocoa, and Diabetes Study
Authors: Melo Bruno P. , Zacarias Aline C. , Oliveira Joyce C.C. , De Souza Cordeiro Letícia M. , Wanner Samuel P. , Dos Santos Mara L. , Avelar Gleide F. , Meeusen Romain , Heyman Elsa , Soares Danusa D. 
Published: November 2021

We aimed to investigate the combined effects of aerobic exercise (EXE) and cocoa flavanol (COCOA) supplementation on performance, metabolic parameters, and inflammatory and lipid profiles in obese insulin-resistant rats. Therefore, 32 male Wistar rats (230–250 g) were fed a high-fat diet and a fructose-rich beverage for 30 days to induce insulin resistance. Next, the rats were randomized into four groups, orally administered placebo solution or COCOA supplementation (45 mg·kg−1), and either remained sedentary or were subjected to EXE on a treadmill at 60% peak velocity for 30 min, for 8 weeks. Blood samples and peripheral tissues were collected and processed to analyze metabolic and inflammatory parameters, lipid profiles, and morphological parameters. Supplementation with COCOA and EXE improved physical performance and attenuated body mass gain, adipose index, and adipocyte area. When analyzed as individual interventions, supplementation with COCOA and EXE improved glucose intolerance and the lipid profile reduced the concentrations of leptin, glucose, and insulin, and reduced homeostasis assessment index (all effects were p < .001 for both interventions), while ameliorated some inflammatory mediators in examined tissues. In skeletal muscles, both COCOA supplementation and EXE increased the expression of glucose transporter (p < .001 and p < .001), and combined intervention showed additive effects (p < .001 vs. COCOA alone or EXE alone). Thus, combining COCOA with EXE represents an effective nonpharmacological strategy to treat insulin resistance; it could prevent Type 2 diabetes mellitus by improving physical performance, glucose metabolism, neuroendocrine control, and lipid and inflammatory mediators in the liver, pancreas, adipose tissue, and skeletal muscle in obese male insulin-resistant rats.
Morphologic signatures of autogenic waterfalls: A case study in the San Gabriel Mountains, California
Authors: Groh Erika L. , Scheingross Joel S. 
Published: November 2021

AbstractWaterfalls can form due to external perturbation of river base level, lithologic heterogeneity, and internal feedbacks (i.e., autogenic dynamics). While waterfalls formed by lithologic heterogeneity and external perturbation are well documented, there is a lack of criteria with which to identify autogenic waterfalls, thereby limiting the ability to assess the influence of autogenic waterfalls on landscape evolution. We propose that autogenic waterfalls evolve from bedrock bedforms known as cyclic steps and therefore form as a series of steps with spacing and height set primarily by channel slope. We identified 360 waterfalls split between a transient and steady-state portion of the San Gabriel Mountains in California, USA. Our results show that while waterfalls have different spatial distributions in the transient and steady-state landscapes, waterfalls in both landscapes tend to form at slopes &gt;3%, coinciding with the onset of Froude supercritical flow, and the waterfall height to spacing ratio in both landscapes increases with slope, consistent with cyclic step theory and flume experiments. We suggest that in unglaciated mountain ranges with relatively uniform rock strength, individual waterfalls are predominately autogenic in origin, while the spatial distribution of waterfalls may be set by external perturbations.
Holocene wet episodes recorded by magnetic minerals in stalagmites from Soreq Cave, Israel
Authors: Burstyn Yuval , Shaar Ron , Keinan Jonathan , Ebert Yael , Ayalon Avner , Bar-Matthews Miryam , Feinberg Joshua M. 
Published: November 2021

Abstract
This study demonstrates the feasibility of speleothem magnetism as a paleo-hydrology proxy in speleothems growing in semi-arid conditions. Soil-derived magnetic particles in speleothems retain valuable information on the physicochemical conditions of the overlying soil, and changes in bedrock hydrology. Yet, the link between magnetic and isotopic proxies of speleothems has been only partly established. We reveal strong coupling between the inflow of magnetic particles (quantified using the magnetic flux index, IRMflux) and δ13C in two Holocene speleothems from Soreq Cave (Israel). The stalagmite record spans from ca. 9.7 to ca. 5.4 ka, capturing the warm-humid conditions associated with the early Holocene and the transition to mid-Holocene wet-dry cycles. Extremely low IRMflux during the early Holocene, indicating minimal contribution from the overlying soil, is accompanied by anomalously high δ13C (approaching bedrock values) hypothesized to be caused by high rainfall and soil erosion. By contrast, IRMflux during the mid-Holocene covaries with the saw-tooth cyclicity of δ13C and δ18O, interpreted as rapid fluctuations in rainfall amount. The peaks in IRMflux precede the negative (wet) δ13C peaks by ~60–120 yr. The apparent lag is explained as a rapid physical translocation of overlying soil particles via groundwater (high IRMflux) as a response to increasing rainfall, compared with slower soil organic matter turnover rates (10–102 yr).
Eocene fault-controlled fluid flow and mineralization in the Paradox Basin, United States
Authors: Bailey Lydia R. , Kirk Jason , Hemming Sidney R. , Krantz Robert W. , Reiners Peter W. 
Published: November 2021

Abstract
Sedimentary rocks of the Paradox Basin of the Colorado Plateau (southwestern USA) record widespread manifestations of paleo–fluid flow and fluid-rock reactions including Cu, U-V, and Fe-Mn mineral deposits, Si and Ca metasomatism, hydrocarbon accumulations, and bleached sandstones. Many of these are spatially associated with faults. Here we show evidence for a widespread phase of fault-related fluid migration and mineralization at 41–48 Ma in the Paradox Basin. We measured K-Ar dates of multiple size fractions of clay-rich fault gouge, yielding statistically overlapping dates of authigenic (1Md) illite for the Salt Valley (47.0 ± 3.0 Ma), Kane Springs (47.7 ± 3.8 Ma), Cliffdweller (43.4 ± 4.6 Ma), Courthouse (41.9 ± 2.3 Ma), Lisbon Valley (45.3 ± 0.9 Ma), and GTO (48.1 ± 2.6 Ma) faults. The latter two have an illite Rb-Sr isochron age of 50.9 ± 3.5 Ma, and fault-adjacent bornite has a Re-Os isochron age of 47.5 ± 1.5 Ma. Authigenic illite from a paleo–oil reservoir near the Courthouse fault formed from the interaction of reduced fluids with oxidized red-bed sandstones at 41.1 ± 2.5 Ma. The Moab and Keystone faults have older authigenic illite ages of 59.1 ± 5.7 Ma and 65.2 ± 1.0 Ma, respectively. Our results show a close temporal relationship between fault gouge formation, red-bed bleaching, and Cu mineralization during an enigmatic time interval, raising questions about drivers of Eocene fluid flow.
Eolian stratigraphic record of environmental change through geological time
Authors: Cosgrove G.I.E. , Colombera L. , Mountney N.P. 
Published: November 2021

Abstract
The terrestrial sedimentary record provides a valuable archive of how ancient depositional systems responded to and recorded changes in Earth's atmosphere, biosphere, and geosphere. However, the record of these environmental changes in eolian sedimentary successions is poorly constrained and largely unquantified. Our study presents the first global-scale, quantitative investigation of the architecture of eolian systems through geological time via analysis of 55 case studies of eolian successions. Eolian deposits accumulating (1) under greenhouse conditions, (2) in the presence of vascular plants and grasses, and (3) in rapidly subsiding basins associated with the rifting of supercontinents are represented by significantly thicker eolian dune-set, sand-sheet, and interdune architectural elements. Pre-vegetation eolian systems are also associated with more frequent interactions with non-eolian environments. The interplay of these forcings has resulted in dune-set thicknesses that tend to be smallest and largest in Proterozoic and Mesozoic successions, respectively. In the Proterozoic, the absence of sediment-binding plant roots rendered eolian deposits susceptible to post-depositional wind deflation and reworking by fluvial systems, whereby highly mobile channels reworked contiguous eolian deposits. During the Mesozoic, humid greenhouse conditions (associated with relatively elevated water tables) and high rates of basin subsidence (associated with the breakup of Pangea) favored the rapid transfer of eolian sediment beneath the erosional baseline. The common presence of vegetation promoted accumulation of stabilizing eolian systems. These factors acted to limit post-depositional reworking. Eolian sedimentary deposits record a fingerprint of major environmental changes in Earth history: climate, continental configuration, tectonics, and land-plant evolution.
Early Pennsylvanian sediment routing to the Ouachita Basin (southeastern United States) and barriers to transcontinental sediment transport sourced from the Appalachian orogen based on detrital zircon U-Pb and Hf analysis
Authors: Allred Isaac J. , Blum Michael D. 
Published: November 2021

Abstract
Carboniferous sediment dispersal from the Appalachian orogenic system (eastern United States) has become a topic of widespread interest. However, the actual pathways for continental-scale, east-to-west sediment transfer have not been documented. This study presents detrital zircon (DZ) U-Pb ages and Hf isotopic values from the Lower Pennsylvanian (Morrowan) Jackfork Group and Johns Valley Shale of the synorogenic Ouachita deepwater basin of Arkansas to document provenance and delineate the likely sediment-routing systems within the broader context of sediment dispersal across Laurentia.
Twelve (12) DZ U-Pb age distributions are interpreted to indicate that sediments were derived from the Appalachians to the east and northeast, as well as the midcontinent region to the north. All samples display prominent ca. 500–400 Ma, 1250–950 Ma, 1550–1300 Ma, and 1800–1600 Ma grains, consistent with ultimate derivation from the Appalachian, Grenville, Midcontinent, and Yavapai-Mazatzal provinces. DZ Hf values obtained from the Ouachita Basin are similar to published Hf values from Pennsylvanian samples in the Appalachian and Illinois Basins. Age distributions are generally consistent for seven samples collected from the Jackfork Group and Johns Valley Shale in the southern Ouachita Mountains through ~2400 m of stratigraphic section and are interpreted to indicate little change in provenance during the Morrowan in this part of the system. However, samples from the most northern and most source-proximal site in Little Rock, Arkansas, exhibit modest percentages of Appalachian ages and elevated contributions of Yavapai-Mazatzal ages when compared with samples collected farther to the south and west. We interpret differences between DZ signatures to indicate distinct sediment-routing pathways to the Ouachita Basin. We infer the strong Appalachian and Grenville signals to represent an axial system flowing through the Appalachian foredeep, whereas the more diverse signals represent a confluence of rivers from the northeast through the backbulge of southern Illinois and western Kentucky and from the north across the Arkoma shelf. Collectively, the Ouachita Basin represents a terminal sink for sediments derived from much of the eastern and central United States.
Preincubation of donor tissue with a VEGF cytokine trap promotes subsequent high-risk corneal transplant survival
Authors: Zhang Wei , Schönberg Alfrun , Hamdorf Matthias , Georgiev Tihomir , Cursiefen Claus , Bock Felix 
Published: November 2021

AimsPathological neovascularisation of the host bed and the transplant itself is the main risk factor for graft rejection after corneal transplantation. This study aims to prevent this process by preincubation of the corneal donor tissue ex vivo with an antivascular endothelial growth factor (VEGF) cytokine trap blocking additional postsurgical hemangiogenesis and lymphangiogenesis to promote high-risk graft survival.MethodsThe donor tissue was preincubated with a VEGFR1R2 cytokine trap for 24 hours prior to murine high-risk corneal transplantation (human IgG Fc was used as the control). The distribution of VEGFR1R2 Trap in the cornea was investigated by immunohistochemistry. Corneas were excised to quantify the blood vessels (BVs) and lymphatic vessels (LVs) and draining lymph nodes (dLNs) were harvested to analyse the phenotype of dendritic cells (DCs) and T cells at week 1, 2 and 8 post-transplantation. Graft survival was compared between preincubation with VEGFR1R2 Trap and human IgG Fc in high-risk recipients.ResultsVEGFR1R2 Trap was present in the graft for at least 2 weeks after surgery and additionally diffused into the corneal recipient. BVs, LVs and macrophages in the whole cornea were significantly decreased 1-week and 2-week post-transplantation (p<0.05). In dLNs the frequency of CD11c+DCs was significantly reduced, whereas CD200R+ regulatory DCs were significantly increased after keratoplasty (p<0.05). Furthermore, long-term high-risk graft survival was significantly improved (p<0.01).ConclusionsPreincubation of corneal donor tissue with a VEGFR1R2 cytokine trap can significantly promote subsequent high-risk corneal transplant survival and thereby opens new treatment avenues for high-risk corneal transplantation.