bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação das características fisico-químicas e da rotulagem nutricional de kombucha industrializada e refrigerante
Authors: Maria Tavares Araújo Nicolly , Teotônio do Nascimento Nágila , Facundo Aragão Márcia 
Published: May 2021

RESUMO: O avanço científico e tecnológico trouxe consigo uma elevada compreensão sobre os benefícios apontados por bebidas de características “funcionais”, os quais estão sendo vendidos em crescente escala e se tornando cada vez mais populares. A kombucha é uma bebida não alcoólica resultante da fermentação de chá e açúcar, juntamente com uma colônia de bactérias e leveduras denominado SCOBY, composta por probióticos e micronutrientes gerados no processo fermentativo. O objetivo deste trabalho foi avaliar as características físico-químicas e rotulagem nutricional de kombuchas industrializadas e refrigerantes, fazendo um comparativo entre as amostras. Foram analisadas as concentrações de acidez, ácido ascórbico e sólidos solúveis totais das amostras de kombuchas, sendo uma feita com chá verde e outra com hibisco e ambas de marcas distintas, como também do refrigerante de sabor guaraná. Os resultados foram submetidos a análise estatística e dentre as kombuchas, a de sabor hibisco apresentou maiores concentrações de acidez (0,98%) e ácido ascórbico (2,89%), já o refrigerante mostrou-se com maior teor de sólidos totais (10,4 ºBrix), seguido da kombucha sabor hibisco (5,4 ºBrix) e chá verde (3,0 ºBrix). Segundo as informações nutricionais presentes no rótulo da kombucha sabor hibisco, este apresentou algumas não conformidades: unidade de medida incorreta e valores de sólidos solúveis menores do que foram encontrados. Diante do resultado é possível concluir que, além de ser um produto com ingredientes naturais a kombucha seria uma boa opção para a substituição dos refrigerantes, levando aos seus consumidores uma melhor qualidade alimentícia e promovendo mais saúde a estes.
Palavras-chave: Bebida gaseificada, chá, promoção de saúde.
DESENVOLVIMENTO E ACEITAÇÃO SENSORIAL DE “IOGURTE” DE SOJA ORGÂNICO E CONVENCIONAL
Authors: De Souza Rezer Ana Paula , Cecconi Deon Barbara , Oliveira Hornes Marcio , Granella Vanusa , Rodrigues Mota Letícia Carine 
Published: May 2021

A soja é considerada uma das melhores alternativas para substituição das proteínas de origem animal. É importante fonte de fibras, oligossacarídeos com potencial prebiótico, como rafinose e estaquiose, vitaminas e minerais, antioxidantes naturais, isoflavonas e fosfolipídeos. O consumo da soja orgânica cresce juntamente com a tendência da sociedade de buscar hábitos de vida mais saudáveis. A soja orgânica é uma ótima alternativa para produção de leite de soja e derivados, como o iogurte, possibilitando o consumo deste produto por vegetarianos, veganos e intolerantes à lactose. Este trabalho teve como objetivo comparar iogurte de soja orgânico e convencional, analisando alguns parâmetros físico-químicos e sensorialmente através do teste de preferência e aceitação. O iogurte orgânico foi preparado com matéria-prima de origem orgânica (soja, açúcar e polpa de morango). Os resultados dos parâmetros físico-químicos para os dois produtos avaliados estão dentro dos limites para produtos fermentados. Não houve diferença significativa nos testes sensoriais de preferência. Os índices de aceitação para os atributos avaliados, nos dois iogurtes, ficaram com valores muito próximos, o que leva a concluir que o desenvolvimento de iogurte com soja orgânica ou convencional não altera os aspectos físico-químicos e sensoriais do produto obtido.
INFLUÊNCIA DA CONCENTRAÇÃO DE SACAROSE E GORDURA SOBRE A CARACTERÍSTICAS DO DOCE DE LEITE OVINO ZERO LACTOSE
Authors: Almeida Carlos , Karolina Cherobin Ana , Perin Larissa , Mohr Elisa , Rigo Elisandra 
Published: May 2021

RESUMO: A produção e o processamento industrial de leite de ovelhas ainda é muito pequeno no Brasil, assim percebesse uma necessidade de melhorar a qualidade e diversidade dos produtos lácteos ovinos ofertados a população, o doce de leite é um produto lácteo muito apreciado por seus consumidores, com grande importância para o mercado brasileiro assim este trabalho teve por objetivo desenvolver um doce de leite pastoso elaborado com leite de ovelha zero lactose com diferentes concentrações de gordura e sacarose avaliando a influência dos mesmos sobre as características físico-químicas, textura e cor. Com este trabalho pode-se verificar que tanto a gordura quando a sacarose desempenham funções importantes que influenciaram as características do doce de leite, observou ainda concentração de sacarose foi a variável que mais influenciou as características avaliadas sendo determinantes para o teor de sólidos, cinzas proteínas, textura e cor.
Palavras-chave: Reação de Maillard. Produtos Lácteos. Textura Instrumental.
Resíduos de laranja e camarão utilizados para produção enzimática com Penicillium commune e Aspergillus sp.
Authors: Melo Cavalcante Bianca Darck 
Published: May 2021

Os resíduos agroindustriais podem ser utilizados como substrato em processos fermentativos para obter bioprodutos de interesse comercial. Devido ao elevado volume de cascas de laranja e camarão gerados e aos seus nutrientes, o objetivo deste estudo é avaliar a viabilidade do uso desses resíduos como substrato para a fermentação submersa e produção enzimática. Foi realizada fermentação submersa com casca de laranja e camarão; Penicillium commune e um fungo isolado de uva (F-39) identificado como Aspergillus sp. foram usados separadamente para a produção dos extratos enzimáticos. Os extratos foram caracterizados quanto às atividades enzimáticas de pectinase, celulase, amilase e peroxidase. Os extratos produzidos por P. commune apresentaram maiores valores de atividades enzimáticas, especialmente celulase (16,87 U mg-1) e amilase (50,73 U mg-1) com p ≤ 0,05. Ambos os extratos apresentaram elevada atividade de peroxidase (> 90 U mg-1). Diante dos resultados obtidos, as cascas de laranja e camarão são uma alternativa eficiente e de baixo custo para a produção enzimática.
The Effect of Supervision, Motivation Andwork Commitment with Employee Performance at Directorate General of Islamic Community Guidance Ministry of Religion of The Republic Of Indonesia
Authors: Aliyati  , Supriyati Yetty , Akbar Ma'ruf 
Published: May 2021

The objective of the research is to find out the effect of supervision, motivation, andwork commitment to the employee performance at DirektoratJenderalBimbinganMasyarakat Islam Kementerian Agama Republik Indonesia.Survey was applied in this study which data have been analyzed by path analysis after all variables put into correlation matrix and multiple regression. In this research, the employee have been chosen as a unit analysis and 150 samples selected randomly. The results of the study found that employee performance was directly influenced by supervision, motivation, and work commitment. And indirectly, employee performance is influenced by the supervisory variable and the motivation variable through work commitment, this shows that the commitment variable is not a good mediating variable. Based on these findings, it can be concluded that the variation of Supervision, Motivation and Commitment each has an effect on employee performance, but the motivation variable is more dominant in influencing employee performance, for that it is suggested to the leadership element that to improve employee motivation performance becomes a benchmark in the success of organizational performance. .
The objective of the research is to find out the effect of supervision, motivation, andwork commitment to the employee performance at DirektoratJenderalBimbinganMasyarakat Islam Kementerian Agama Republik Indonesia.Survey was applied in this study which data have been analyzed by path analysis after all variables put into correlation matrix and multiple regression. In this research, the employee have been chosen as a unit analysis and 150 samples selected randomly. The results of the study found that employee performance was directly influenced by supervision, motivation, and work commitment. And indirectly, employee performance is influenced by the supervisory variable and the motivation variable through work commitment, this shows that the commitment variable is not a good mediating variable. Based on these findings, it can be concluded that the variation of Supervision, Motivation and Commitment each has an effect on employee performance, but the motivation variable is more dominant in influencing employee performance, for that it is suggested to the leadership element that to improve employee motivation performance becomes a benchmark in the success of organizational performance.
Deradicalization of Terrorism Prisoner: Evaluation of The Terrorism Client Guidance Program at the Surakarta Correctional Facility
Authors: Isnanto Samto Hadi , Akbar Ma'ruf , Tunas Billy 
Published: May 2021

The radicalism that leads to terrorism is a threat to almost every country in the world, leading many countries to employ a deradicalization program to deradicalize people that have been influenced by terrorist ideology. This research purpose is to evaluate the effectiveness of deradicalization effort conducted through “terrorism client guidance program at Surakarta Correctional Facility”. Using the CIPP model of evaluation, data is collected from eighteen terrorism clients and a few structural officials as well as all related documents at Surakarta Correctional Facility. The result of this study found that: (1) Evaluation of context component is worth average, (2) Evaluation of input component is worth poor, (3) Evaluation of process component is worth good, and (4) Evaluation of product component is worth average. Overall, the effectiveness of deradicalization conducted through guidance for terrorism client program at Surakarta Correctional Facility is worth average. Although the total evaluation merit of the terrorist client’s guidance program is still in the level of average, however, the author suggests that the program should be continued by revising some areas of concern.

Keywords: Deradicalization, Evaluation Program, Guidance of Terrorism Client.
<p>Reinventing High School: Understanding the Challenges and Successes of
Transforming Education to Meet Student, Society, and Industry Needs</p>
Authors: Bartholomew Scott R. , Strimel Greg J. , Lucietto Anne , Akdere Mesut 
Published: May 2021

Efforts to revamp existing educational systems and approaches result in various
new models in STEM education. Accordingly, a new urban public charter school, located in
a Midwest state in the United States, was established in partnership with the state’s
land-grant university to create a transformed integrated STEM educational environment
characterized by industry-focused and design-based learning to help prepare students for
the future of work and learning. This article presents findings from an exploratory
study that examined the experiences of teachers and administrative staff of this
innovative high school (IHS) during the first year of school operation. A purposive
sample of 16 teachers and administrators from the IHS completed a semi-structured
interview and a focus group. Several themes—related to the experiences during the first
year of the school—from the interviews with the participants emerged including: (1)
developing novel approaches for planning and implementing design-based learning cycles,
(2) facing challenges with personalized learning, (3) establishing methods for creating
authentic and industry-driven learning experiences, (4) addressing challenges with
open-ended learning, (5) confronting concerns about competencies that are not measured
through standardized assessments, (6) struggling with teacher burnout, and (7)
challenging traditional school systems and facilities with integrated learning
environments. Based on these findings, potential implications, considerations, and
future directions for the implementation of innovative industry- driven, design-based
educational approaches are provided. Note. To preserve anonymity the name of the
high school has been generalized and the acronym IHS will be used throughout
Apoptotic mechanisms of myricitrin isolated from Madhuca longifolia leaves in HL-60 leukemia cells
Authors: Sarkar Monaj Kumar , Kar Amrita , Jayaraman Adithyan , Shanmugam Karthi , Vellingiri Vadivel , Mahapatra Santanu Kar 
Published: May 2021

Abstract
Background: Myricitrin, a naturally occurring flavonoid in Madhuca longifolia, possesses several medicinal properties. Even though our earlier work revealed its role against the proliferation of acute myelogenous leukemia cells (HL-60), its molecular mechanisms have not yet been revealed. The current study aims to explore the molecular mechanisms of myricitrin (isolated from an ethnomedicinal drug Madhuca longifolia) to induce apoptosis in HL-60 cells. Methods and Results: Treatment with IC-50 dose of myricitrin (353 µM) caused cellular shrinkage and cell wall damage in HL-60 cells compared to untreated control cells. Myricitrin treatment reduced the mitochondrial membrane potential (22.95%), increased DNA fragmentation (90.4%), inhibited the cell survival proteins (RAS, B-RAF, & BCL-2) and also induced pro-apoptotic proteins (p38, pro-caspase-3, pro-caspase-9 and caspase-3) in the HL-60 cells. Conclusions: The present study provides scientific evidence for the apoptosis caused by myricitrin in HL-60 leukemia cells. Hence, the phytochemical myricitrin could be considered as a potential candidate to develop an anticancer drug after checking its efficacy through suitable pre-clinical and clinical studies.
Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate exposed premature mice: modulatory effect of raw honey against potential anomalies
Authors: Ara Chaman , Asmatullah  , Yaseen Faiza , Ali Shaukat , Shakir Hafiz Abdullah , Khan Muhammad , Andleeb Shagufta , Ramzan Nageena 
Published: May 2021

Abstract
Phthalates, plasticizing chemicals are top-rated environmental contaminants. Diethyl phthalate (DEP), a chief member of this family was declared a potent endocrine-disruptor and carcinogen in animals and humans. The current study was designed to explore the probable reproductive damage induced by DEP and the therapeutic efficacy of raw honey in male albino mice. Four weeks old 50 male mice, were randomized equally in five groups, as control (C) received 0.1 ml distilled water; vehicle control (VC) received 0.1 ml corn oil; DEP (3mg/g/BW) dissolved in corn oil; Honey control (HC) administered 0.2 mg/g/day); P + H administered with DEP and honey (3mg and 0.2 mg/g/BW/day respectively). Mice were treated through oral gavage for 54 days routinely, acclimatized for 6 days and dissected. In the first instance, the antioxidant potential and total phenolic contents of honey were analyzed through Ferric reducing antioxidant power assay and Folin-Ciocalteu assay to confirm the antioxidant capacity of honey. The morphological, morphometric, histological, micrometric, sperm count, hormonal analyses, and antioxidant capacity test in tissue homogenates were conducted by using tissues (testis, epididymis) and blood samples of mice. Mice exposed to DEP have a significant increase in body weight, LH level, seminiferous tubule lumen diameter and decrease in the gonado-somatic index, testosterone level, sperm count, and seminiferous tubule diameter. Additionally, histopathology of testes showed interstitial spaces dilations, exfoliations, Leydig cells atrophy, germ cell degenerations and spermatid retention in DEP exposed testes sections. However, concomitant use of honey and DEP had shown a significant improvement in histopathological lesions, steroid hormone levels, and healthy sperm count. By these results, it is concluded that honey possessed antioxidant potential that can efficiently protect DEP-induced anomalies in male mice.
Distribution and size variability of Japanese eel leptocephali in their Pacific Ocean spawning area using carbon and nitrogen stable isotope ratio analyses
Authors: Kimura Shingo , Miyazaki Sachie , Onda Hiroaki , Kitagawa Takashi , Miyake Yoichi , Miller Michael J , Tsukamoto Katsumi 
Published: May 2021

Abstract
The diets of larval (leptocephali) anguillid and marine eels are poorly understood, despite studies on their gut contents or stable isotope ratios suggesting marine snow particles represent a food source. Concerns for Japanese eel Anguilla japonica stock conservation necessitate an improved knowledge of their larval ecology to better understand the causes of their recent decline in numbers and fluctuating recruitment into East Asia. To understand the distribution of and variation in size of leptocephali in relation to their feeding, we examine carbon and nitrogen stable isotope ratios of larvae from seven research cruises (2002–2013) in the North Equatorial Current spawning area. Preleptocephali (2–3 days old, ~5 mm total length) isotope ratios reflect maternal ratios, but feeding-stage leptocephali (8–56 mm) tend to have higher ∂15N values with decrease of latitude typically in areas south of a salinity front. Neither ∂15N nor ∂13C ratios are clearly related to longitude or larval size < 30 mm, but ∂13C values of larvae > 40 mm are lower further downstream in the North Equatorial Current and Subtropical Countercurrent. Differences in ∂13C values might be a function of varying spatial baselines in the two currents apart from the spawning area. Although among-year larval isotope ratio differences may reflect temporal baseline variation related to the location of the salinity front, more research with much wider range observations in the spawning season is required because ingested marine snow particles might differ with larval growth and location.
Novel Natural Inhibitors Targeting AKT1 by Computational Study
Authors: Wu Bo , Yang Wenzhuo , Zhang Zhiyun , Dou Gaojing , Lv Xiaye , Wang Xinhui , Ge Junliang , Pan Xuefeng , Wang Hongyu , Zhong Sheng 
Published: May 2021

Abstract
Object: This study was designed to screen ideal lead compounds and drug candidates with an inhibitory effect on AKT1 from the drug library (ZINC database).Methods: A battery of computer-aided virtual techniques were used to identify potential inhibitors of AKT1. LibDock is used for structure-based screening followed by ADME (absorption distribution, metabolic excretion) and toxicity prediction. Molecular dynamics simulations were used to evaluate the stability of ligand-receptor complexes.Results: Two new natural compounds ZINC000049872065 and ZINC000021992902 were found to bind to AKT1 in the ZINC database, showing a higher binding affinity. Also, they were predicted to have lower rodent carcinogenicity, Ames mutagenicity, developmental toxicity potential, and high tolerance to cytochrome P4502D6. Molecular dynamics simulation shows that ZINC000049872065 and ZINC000021992902 have more favorable potential energies with AKT1, which can exist stably in the natural environment.Conclusion: This study suggests that ZINC000049872065 and ZINC000021992902 are ideal potential inhibitors of AKT1 targeting. These compounds are safe drug candidates and have important implications for the design and improvement of C-MET target drugs.
Effects of S24-7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy
Authors: Yang Xin , Tang Ting , Wen Jing , Li Mengchun , Chen Jie , Li Tingyu , Dai Ying , Cheng Qian 
Published: May 2021

Abstract
Antibiotic exposure during pregnancy will adversely affect the growth of offspring; however, this remains controversial and the mechanism is poorly understood. To study this phenomenon, we added ceftriaxone sodium to the drinking water of pregnant rats and continuously monitored the body weight of their offspring. The results showed that compared with the control group, the offspring exposed to antibiotics during pregnancy had a higher body weight up to 3 weeks old but had a lower body weight at 6 weeks old. To determine the role of the gut microbiota and its metabolites in the growth of offspring, we collected feces for sequencing and further established that the experimental group has a different composition ratio of dominant bacteria at 6 week old, among which S24-7 correlated negatively with body weight and the metabolites that correlated with body weight-related unique flora were L-Valine, L-Leucine, Glutaric acid, N-Acetyl-L-glutamate, and 5-Methylcytosine. To further explore how they affect the growth of offspring, we submitted these data to Kyoto Encyclopedia of Genes and Genomes website for relevant pathway analysis. The results showed that compared with the control, the following metabolic pathways changed significantly: Valine, leucine, and isoleucine biosynthesis; Protein digestion and absorption; and Mineral absorption. Therefore, we believe that our findings support the conclusion that ceftriaxone sodium exposure in pregnancy has a long-lasting adverse effect on the growth of offspring because of an imbalance of gut microbiota, especially S24-7, via different metabolic pathways.
Endoscopic Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion In 1-Segment Lumbar Spondylolisthesis: A Prospective Randomised Pilot Study
Authors: Lv You , Chen Ming , Qin Ru-Jie , Ma Cheng , Ding Qi-Rui , Qin Hao-Nan , Chen Jing-Yang , Wang Xiang-fu , Wang Shou-Lin , Ren Yong-Xin 
Published: May 2021

Abstract
Background: There are currently several minimally invasive techniques for lumbar spine interbody fusion that have been shown to minimize surgical and perioperative morbidity. We aimed to evaluate the curative efficacy of endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) by comparing perioperative characteristics and 1.5-year observational outcomes in 1-segment lumbar spondylolisthesis between the minimally invasive TLIF (MIS-TLIF) technique and the optimized Endo-TLIF technique. Methods: One hundred and two patients treated by MIS-TLIF (48 cases) or Endo-TLIF (54 cases) were included from March 2018 to April 2019. Perioperative parameters and clinical outcomes were evaluated. Inflammatory biomarkers were measured for postoperative traumatic stress and muscle injury. Fusion rates were determined at 18 months after surgery by CT.Results: The Endo-TLIF group had similar incision length, return to work time and rate (p>0.05). Blood loss, left bed time and analgesic ratio were significantly less in Endo-TLIF group (p<0.05). The Endo-TLIF group had a significantly longer operative and radiation exposure time compared with MIS-TLIF group (p<0.05). The CRP and ESR levels were lower in the Endo-TLIF group compared with the MIS-TLIF group (p<0.05). The VAS and ODI improved significantly in both groups after surgery. Significant decreases in low back VAS in the Endo-TLIF group were found at postoperative day 1 and 3 months after surgery (p<0.05). The fusion rate in the Endo-TLIF group (90.7%) was similar to that in the MIS-TLIF group (95.8%).Conclusions: Endo-TLIF has comparable perioperative analysis and clinical outcomes in comparison to MIS-TLIF and manifests a greater improvement in less multifidus muscle damage, inflammation and faster patient recovery. Thus, Endo-TLIF should be considered as a feasible and effective technique for 1-segment lumbar spondylolisthesis patients with similar fusion rate.Trial registration: ChiCTR1800015197, 13 March 2018. Trial registry: Chinese Clinical Trial Registry. Registered 13 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25865