bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atuação do enfermeiro no gerenciamento dos eventos adversos realacioandos aos cateter venoso central: revisão integrativa
Authors: Feitoza Pereira Adriana , Andrade Ana Fátima Souza Melo de , Teles Weber de Santana , Silva Max Cruz da , Torres Ruth Cristini , Barros Ângela Maria Melo Sá , Azevedo Marcel Vinícius Cunha , Debbo Alejandra , Morais Andre Luiz de Jesus , Silva Maria Hozana Santos , Calasans Taíssa Alice Soledade , Santos Junior Paulo Celso Curvelo 
Published: August 2021

O Cateter Venoso Central é um dispositivo intravascular, cuja extremidade distal está situada próxima ou no interior do átrio direito, podendo ser inserida também em vasos de grande calibre e tem como finalidade possibilitar a infusão venosa contínua ou intermitente, administração de hemocomponentes e hemoderivados, nutrição parenteral, entre outros. Este estudo tem como objetivo descrever a atuação do enfermeiro na gestão do cuidado e gerenciamento de eventos adversos associados ao cateter venoso central. Trata-se de uma revisão bibliográfica da literatura, cujos artigos foram filtrados nas bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), PubMed, Base de Dados de Enfermagem (BDENF) e Google Acadêmico. O estudo evidenciou a importância de gerenciar riscos inerentes à cateterização, desde sua inserção até remoção. A infecção da correntes sanguínea gastou destaque como um dos principais eventos. Destacou-se também a necessidade da utilização de bundles, enfatizando a importância da cultura de segurança. Portanto, conclui-se que o enfermeiro tem um papel essencial na prevenção e controle de infecções, pois assiste diretamente os pacientes, manipulam e controlam dispositivos, conexões e medicações. A utilização de bundles são eficazes na redução das taxas de infecção.
Fatores associados aos acidentes e complicações na extração de terceiros molares: uma revisão de literatura
Authors: Flor Lara Carolyne de Sousa , Trinta Luana Barbieri , Gomes Ana Viviam Souza Ferro , Figueiredo Ramon Barros , Sousa Anna Carolina Azevedo , Silva Larissa de Cássia Nunes da , Gomes Felipe Silva , Freire Millena Daniella Pinheiro , Agostinho Cícero Newton Lemos Felicio 
Published: August 2021

Complicações são o que acontecem após o ato cirúrgico, enquanto acidentes são aqueles que acontecem fora do planejamento, no período transoperatório. A literatura evidencia que, entre os principais acidentes e complicações durante e após o procedimento de exodontia de terceiros molares, estão a fratura de elemento (s) dentário (s), parestesia do nervo alveolar inferior, comunicação buco-sinusal, hemorragia, hematoma, alveolite, dor, edema, trismo, luxação da articulação e fratura de mandíbula. Por esse motivo, é imprescindível que o cirurgião-dentista busque conhecimento prévio teórico e prático dos procedimentos odontológicos a serem realizados, assim como meios de condutas e cuidados em casos de intercorrências. O presente trabalho relata uma revisão de literatura narrativa sobre complicações e acidentes cirúrgicos de terceiros molares, tendo como objetivo discorrer sobre os fatores que levam ao seu surgimento. As bases de dados selecionadas para o estudo foram Google Acadêmico e Pubmed, sendo selecionados mediante critérios de inclusão e exclusão estabelecidos.
Bio-Fabrication of Human Amniotic Membrane Zinc Oxide Nanoparticles and the Wet/Dry HAM Dressing Membrane for Wound Healing
Authors: Ramasamy Palaniappan , Krishnakumar Ramachandran , Rekha Ravichandran , Vaseeharan Baskaralingam , Saraswathi K. , Raj Mohan , Hanna Robert E. B. , Brennan Gerard P. , Dayanithi Govindan , Vijayakumar Sekar 
Published: August 2021

Graphical AbstractFlow chart depicting the methods, preparing, and characterizing, by histological, and scanning electron microscopy, of wet (PW-HAM) and dry (PD-HAM)of wound healing dressing, and preparation of nanoparticles (HAMP ZnO NP); and application of HAM wound dressing.
PUM1 Is Overexpressed in Colon Cancer Cells With Acquired Resistance to Cetuximab
Authors: Liu Qizhi , Xin Cheng , Chen Yikuan , Yang Jiawen , Chen Yingying , Zhang Wei , Ye Lechi 
Published: August 2021

BackgroundCetuximab is an effective antibody to treat colorectal cancer (CRC) by targeting the epidermal growth factor receptor (EGFR). However, the mechanisms of acquired resistance to cetuximab therapy, especially in patients without identifiable gene mutations, are not fully understood.MethodsOur study investigated the role of pumilio RNA-binding family member 1 (PUM1) in cetuximab resistance. We established cetuximab-resistant colon cancer cell lines SW480R and Caco-2R and knocked out PUM1 and DEAD-box helicase 5 (DDX5) with the clustered regularly interspaced short palindromic repeats (CRISPR)-caspase 9 (Cas9) system. To check cell proliferation, we used Cell Counting Kit-8. We performed qPCR and immunoblot to examine the levels of mRNAs and proteins for each cell line.ResultsOur data showed that PUM1 was upregulated in SW480R and Caco-2R cells with increased protein levels and cell proliferation, and PUM1 knockout reduced cell viability in the presence of cetuximab. We also found that PUM1 interacted with DDX5 in 3′ untranslated region (UTR) and positively regulated its mRNA expression. Furthermore, suppression of DDX5 also decreased the proliferation of SW480R and Caco-2R cells.ConclusionOur study suggests that PUM1 positively regulates DDX5 and acts as a promoter in cetuximab-resistant colon cancer cells.
Investigating Predictability of the TRHR Seasonal Precipitation at Long Lead Times Using a Generalized Regression Model with Regularization
Authors: Peng Xiao , Li Tiejian , Albertson John D. 
Published: August 2021

Skillful long-lead climate forecast is of great importance in managing large water systems and can be made possible using teleconnections between regional climate and large-scale circulations. Recent innovations in machine learning provide powerful tools in exploring linear/nonlinear associations between climate variables. However, while it is hard to give physical interpretation of the more complex models, the simple models can be vulnerable to over-fitting, especially when dealing with the highly “non-square” climate data. Here, as a compromise of interpretability and complexity, we proposed a regression model by coupling pooling and a generalized regression with regularization. Performance of the model is tested in estimating the Three-Rivers Headwater Region wet-season precipitation using the sea surface temperatures at lead times of 0–24 months. The model shows better predictive skill for certain long lead times when compared with some commonly used regression methods including the Ordinary Least Squares (OLS), Empirical Orthogonal Function (EOF), and Canonical Correlation Analysis (CCA) regressions. The high skill is found to relate to the persistent regional correlation patterns between the predictand precipitation and predictor SSTs as also confirmed by a correlation analysis. Furthermore, flexibility of the model is demonstrated using a multinomial regression model which shows good skill around the long lead time of 22 months. Consistent clusters of SSTs are found to contribute to both models. Two SST indices are defined based on the major clusters of predictors and are found to be significantly correlated with the predictand precipitation at corresponding lead times. In conclusion, the proposed regression model demonstrates great flexibility and advantages in dealing with collinearity while preserving simplicity and interpretability, and shows potential as a cheap preliminary analysis tool to guide further study using more complex models.
Synthesis, Optical Characterization, and Adsorption of Novel Hexavalent Chromium and Total Chromium Sorbent: A Fabrication of Mulberry Stem Biochar/Mn-Fe Binary Oxide Composite via Response Surface Methodology
Authors: Xu Shuiping , Liang Meina , Ding Yanmei , Wang Dunqiu , Zhu Yinian , Han Linbo 
Published: August 2021

In this study, a new generation chromium sorbent, mulberry stem biochar/Mn-Fe binary oxide composite (MBC-MFC), was fabricated by chemical precipitation on carbonized mulberry stem according to response surface methodology (RSM) results. RSM was more convenient to figure out the optimized preparation condition of MBC-MFC theoretically for achieving a maximum removal efficiency of Cr(VI) and total chromium (TCr), compared to labor-intensive orthogonal experiments. The RSM results showed that Fe/Mn concentration (CFe; CMn), MBC activation temperature after soaking in KOH solution (T), and pH during precipitation of Fe-Mn oxide were three main factors to significantly affect the efficiency of MBC-MFC (p &lt; 0.05) in Cr(VI) and TCr removal. With the selected condition (CFe = 0.28 mol/L; CMn = 0.14 mol/L; T = 790°C; pH = 9.0), MBC-MFC was synthesized with a large surface area (318.53 m2/g), and the point of zero charge values of MBC-MFC was 5.64. The fabricated MBC-MFC showed excellent adsorption performance of Cr(VI) and TCr in an aqueous solution. The maximum Cr(VI) and TCr removal capacity of MBC-MFC was 56.18 and 54.97 mg/g (T = 25°C, pH = 3.0, t = 48 h, and dosage = 0.10 g/50 ml), respectively, and the maximum Cr(VI) adsorption of MBC-MFC was 4.16 times that of bare MBC, suggesting the synergistic effects of Fe/Mn oxides and MB on the performance of MBC-MFC in Cr(VI) and TCr removal. The adsorption mechanism of MBC-MFC on chromium was mainly contributed by surface complexation and electrostatic attraction. Our study offers valuable outlooks to develop high-performance biochar-based sorbents for heavy metal removal and sustainable environmental remediation.
A Ferroptosis-Related Gene Model Predicts Prognosis and Immune Microenvironment for Cutaneous Melanoma
Authors: Xu Congcong , Chen Hao 
Published: August 2021

BackgroundCutaneous melanoma is a common but aggressive tumor. Ferroptosis is a recently discovered cell death with important roles in tumor biology. Nevertheless, the prognostic power of ferroptosis-linked genes remained unclear in cutaneous melanoma.MethodsCutaneous melanoma patients of TCGA (The Cancer Genome Atlas) were taken as the training cohort while GSE65904 and GSE22153 as the validation cohorts. Multifactor Cox regression model was used to build a prognostic model, and the performance of the model was assessed. Functional enrichment and immune infiltration analysis were used to clarify the mechanisms.ResultsA five ferroptosis-linked gene predictive model was developed. ALOX5 and GCH1 were illustrated as independent predictive factors. Functional assessment showed enriched immune-linked cascades. Immune infiltrating analysis exhibited the distinct immune microenvironment.ConclusionHerein, a novel ferroptosis-related gene prognostic model was built in cutaneous melanoma. This model could be used for prognostic prediction, and maybe helpful for the targeted and immunotherapies.
Serum Exosomal Circular RNA Expression Profile and Regulative Role in Proliferative Diabetic Retinopathy
Authors: Li Xinsheng , Wang Jingfan , Qian Huiming , Wu Yan , Zhang Zhengyu , Hu Zizhong , Xie Ping 
Published: August 2021

BackgroundProliferative diabetic retinopathy (PDR), as one of the main microvascular complications of diabetes mellitus, seriously threatens the visual function of the working-age population; yet, the underlying pathogenesis is still poorly understood. This study aimed to identify the distinct exosomal circular RNA (circRNA) expression in PDR serum and preliminarily explore the potential pro-angiogenic mechanism of specific exosomal circRNAs.MethodsWe collected serum samples from 10 patients with PDR and 10 patients with age-matched senile cataract to detect the exosomal differentially expressed genes (DEGs) of circRNAs via high-throughput sequencing, followed by validation with quantitative real-time PCR (qRT-PCR). Next, bioinformatics analyses including competitive endogenous RNA (ceRNA) network, protein–protein interaction network (PPI), and functional enrichment analyses were performed. In addition, the potential function of circFndc3b (hsa_circ_0006156) derived from high-glucose-induced endothelial cells was analyzed in human retinal vascular endothelial cells (HRVECs).ResultsIn total, 26 circRNAs, 106 microRNAs (miRNAs), and 2,264 messenger RNAs (mRNAs) were identified as differentially expressed in PDR serum exosomes compared with cataract serum exosomes (fold change &gt; 1, P &lt; 0.05). A circRNA–miRNA–mRNA ceRNA network was established. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the mRNAs were mainly enriched in the PI3K–Akt signaling pathway, MAPK signaling pathway, Wnt signaling pathway, and VEGF signaling pathway. The PPI network and module analysis identified 10 hub genes, including RhoA, Cdc42, and RASA1. Finally, circFndc3b and exosomes derived from high-glucose-induced endothelial cells were identified with the capability to facilitate angiogenesis in vitro.ConclusionAberrant profiling of exosomal circRNAs in PDR serum was identified. CircFndc3b derived from high-glucose-induced endothelial cells may play an important role in the angiogenesis of PDR.
New Advances in the Kinetic Modeling of Thermal Oxidation of Epoxy-Diamine Networks
Authors: Colin Xavier , Delozanne Justine , Moreau Gurvan 
Published: August 2021

This article deals with the thermal oxidation mechanisms and kinetics of epoxy-diamine (EPO-DA) networks used as composite matrices reinforced with carbon fibers in the aeronautical field. The first part of this article is devoted to a detailed presentation of the new analytical kinetic model. The so-called “closed-loop” mechanistic scheme, developed in the last 3 decades in our laboratory in order to accurately describe the thermal oxidation kinetics of saturated hydrocarbon polymers, is recalled. Its main characteristics are also briefly recalled. Then, the system of differential equations derived from this oxidation mechanism is analytically solved without resorting to the usual simplifying assumptions that seriously degrade the reliability of all kinetic models. On the contrary, the generalization of the proportionalities observed between the steady concentrations of the different reactive species (i.e., hydroperoxides and alkyl and peroxy radicals) to the entire course of thermal oxidation gives a series of much sounder equations. From this basis, the kinetic model is completed by considering new structure/property relationships in order to predict the consequences of thermal oxidation on the thermomechanical properties, in particular on the glass transition temperature (Tg). To reach this second objective, the two main mechanisms responsible for the alteration of the macromolecular network structure are recalled: chain scissions and crosslinking. Like any other chemical species, their kinetics are directly expressed from the oxidation mechanistic scheme using the classical concepts of chemical kinetics. The second part of this article is devoted to the checking of the kinetic model reliability. It is shown that this latter accurately simulates the experimental curves of carbonyl build-up and Tg decrease versus time of exposure determined in our laboratory for three EPO-DA networks under study, exposed in a wide variety of thermal oxidative environments. The values determined by inverse solving method for the different model parameters are discussed and their temperature dependence are elucidated. Finally, an end-of-life criterion is proposed for predicting the lifetime of EPO-DA networks involving a predominant chain scission process.
Case Report: A Rare Orbital Abscess Caused by Dacryocystitis After Administration of Rebamipide Ophthalmic Suspension
Authors: Imamura Hitoshi , Eguchi Hiroshi , Sakamoto Masuo , Hotta Fumika , Tabuchi Hitoshi , Kusaka Shunji 
Published: August 2021

Background: Rebamipide ophthalmic suspension was launched in Japan in 2012 and is used for the treatment of dry eye.Case Presentation: We report two cases of orbital abscess, which resulted from dacryocystitis that occurred after administration of rebamipide ophthalmic suspension. Computed tomography images showed an eyeball deformity in one case and exophthalmos in the other. In both cases, light microscopy, scanning electron microscopy and energy dispersive X-ray examinations revealed lacrimal sac concretions, which contained calcium phosphate crystals that were surrounded by microorganisms. Lacrimal sac concretion removal from the lacrimal sacs during dacryocystorhinostomies was performed on both patients. Although the postoperative outcome was favorable in one case, vision was lost in the other case due to the development of retinal artery occlusion as a complication of the orbital abscess, despite lacrimal sac concretion removal and administration of antimicrobials.Conclusions: This is the first case report to highlight that rebamipide ophthalmic suspension can cause an orbital abscess via development of lacrimal sac concretion. Ophthalmologists should be aware that rebamipide ophthalmic suspension might induce the formation of concretion in the lacrimal sac.
Association of Osteoarthritis With Changes in Structural Neuroimaging Markers Over Time Among Non-demented Older Adults
Authors: Wu Lichuang , Wang Xiang , Ye Yiheng , Liu Cailong 
Published: August 2021

Objective: Although emerging evidence suggests that both osteoarthritis (OA) and brain atrophy (as assessed by structural neuroimaging markers) are associated with the risk of dementia, little is known about the association between OA and structural neuroimaging markers. This study aimed to examine the association of OA with changes in structural neuroimaging markers among non-demented older people.Methods: We examined the cross-sectional and longitudinal associations between OA and structural neuroimaging markers (hippocampal volume, entorhinal volume, ventricular volume, and volume of gray matter of the whole brain) among non-demented older people. We categorized our participants as those without OA (OA−) and those with OA (OA+). At baseline, we included 1,281 non-demented older adults, including 1,050 without OA and 231 with OA.Results: In the cross-sectional analysis, we did not observe any significant difference in structural neuroimaging markers between the two OA groups. In the longitudinal analysis, we found that compared to participants without OA, those with OA showed a steeper decline in volumes of the gray matter of the whole brain among non-demented older adults.Conclusions: OA was associated with a steeper decline in volumes of the gray matter of the whole brain over time among non-demented older people.
Does More Sedentary Time Associate With Higher Risks for Sleep Disorder Among Adolescents? A Pooled Analysis
Authors: Zhang Yanjie , Chen Sitong , Wang Chengyao , Zhang Xiaoyi , Zou Liye , Chi Xinli , Jiao Can 
Published: August 2021

Purpose: To investigate the association between sedentary behavior and anxiety-induced sleep disorder at a global perspective.Methods:A total of 254,924 adolescents (mean age: 14.45 ± 1.42 years; 52.8% girls) who participated in the Global School-Based Student Health Survey were included for analysis. Self-reported questionnaires assessed anxiety-induced sleep disorder and sedentary behavior. Multivariable logistic regression analysis and countrywide meta-analysis were used for investigating the association between sedentary behavior and anxiety-included sleep disorder.Results:The results showed that sedentary time was linearly associated with higher OR of anxiety-related sleep disorder in adolescents across the countries and that 8 h or more per day increased the OR by 2.17 times. Countrywide meta-analysis showed that 8 h or more per day of sedentary behavior yielded an OR = 1.40 (95% CI = 1.34–1.46) of anxiety-induced sleep disorder. Moreover, the association between sedentary behavior and sleep anxiety was significant in adolescents over the age of 11 years regardless of sex.Conclusions:The findings from this study suggest that as sedentary behavior increases, sleep disorders also increase, independently of sex among adolescents. Effective preventive strategies are needed to be taken to decrease sedentary behavior that could be used to improve mental health and sleep quality among adolescents.
Dose Remittances Matter for Openness and Financial Stability: Evidence From Least Developed Economies
Authors: Miao Meng , Qamruzzaman Md. 
Published: August 2021

The study's motivation is to gauge the effects of remittances on openness: financial and economic openness and financial stability in least developed countries (LDCs) for the period spanning 1975–2018. The study applies Generalized Moment of Methods (GMM) and System-GMM to detect the magnitude of remittances, gross capital formation, and government debt on openness and financial stability, and their directional association is established by performing a Granger causality test with System-GMM specification. The results of cross-sectional dependency ascertain the presence of a common dynamic among the research units; on the other hand, both first, and second-generation unit root tests establish that variables are integrated either at level or after the first difference, neither variables are exposed to order of integration after second difference. A panel co-integration test based on error correction confirms the availability of the long-run association among variables. Study findings with GMM and System-GMM estimation expose positive statistically significant effects of remittance inflows to economic and financial openness and financial stability. In LDCs, remittance inflows positively augment economic and financial openness; moreover, financial stability remittances play a critical role. The study implemented the Granger causality test with System-GMM specification, and results disclosed the feedback hypothesis that is bidirectional causality availability in the tested empirical causal model.JEL Classifications: F24, F43, P34.
Public–Private Mix Models of Tuberculosis Care in Pakistan: A High-Burden Country Perspective
Authors: Ullah Waseem , Wali Ahmad , Haq Mahboob Ul , Yaqoob Aashifa , Fatima Razia , Khan Gul Majid 
Published: August 2021

Introduction:Pakistan ranks fifth in the globally estimated burden of tuberculosis (TB) case incidence. Annually, a gap of 241,688 patients with TB exists between estimated TB incidence and actual TB case notification in Pakistan. These undetected/missed TB cases initiate TB care from providers in the private healthcare system who are less motivated to notify patients to the national database that leads to significant underdetection of actual TB cases in the Pakistani community. To engage these private providers in reaching out to missing TB cases, a national implementation trial of the Public–Private Mix (PPM) model was cohesively launched by National TB Control Program (NTP) Pakistan in 2014. The study aims to assess the implementation, contribution, and relative treatment outcomes of cohesively implemented PPM model in comparison to the non-PPM model.Methods:A retrospective record review of all forms (new and relapse) patients with TB notified from July 2015 to June 2016 was conducted both for PPM- and non-PPM models.Results:The PPM model was implemented in 92 districts in total through four different approaches and contributed 25% (81,016 TB cases) to the national TB case notification. The PPM and non-PPM case notification showed a strong statistical difference in proportions among compared variables related to gender (p&lt; 0.001), age group (p&lt; 0.000), and province (p&lt; 0.000). Among PPM approaches, general practitioners and non-governmental-organization facilities achieve a treatment success of 94–95%; private hospitals achieve 82% success, whereas Parastatals are unable to follow more than half of their notified TB cases.Discussion:The PPM model findings in Pakistan are considerably consistent with countries that have prioritized PPM for an increasing trend in the TB case notification to their national TB control programs. Different PPM approaches need to be scaled up in terms of PPM implemented districts, PPM coverage, PPM coverage efficiency, and PPM coverage outcome in the Pakistani healthcare system in the future.