bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Safety and Effectiveness of Surgical Management of Brachial Plexus Tumors: A Retrospective Case Series
Authors: Al-Mistarehi Abdel-Hameed , Weber-Levine Carly , Jiang Kelly , Alfonzo Horowitz Melanie , Xia Yuanxuan , Fayez Feras , Mendelson Benjamin Z. , Albert Avi N. , Papali Pritika , Neerumalla Sushanth , Theodore Nicholas , Belzberg Allan J. , Lubelski Daniel 
Published: February 2025

BACKGROUND AND OBJECTIVES:
Brachial plexus tumors represent a challenge for neurosurgeons because of complex anatomy, risks during surgery, and limited evidence-based guidance in managing these rare tumors. We aim to investigate the clinical characteristics, complications, and neurological outcomes of surgical resection of benign brachial plexus tumors.

METHODS:
We reviewed the medical records of patients diagnosed with benign brachial plexus tumors at (Johns Hopkins Medical Institutes) from July 2014 to April 2023. Of 123 screened patients, those who had surgical resection for benign brachial plexus tumors were identified.

RESULTS:
A total of 56 patients were included. Their mean (SD) age was 46.79 years (14.67), and 60.7% were women. The most common initial presentations were palpable mass (82.1%) and pain (66.1%). Sensory and motor deficits were reported in 27 (48.2%) and 12 patients (21.4%), respectively. Gross total resection was achieved in 53 patients (94.6%), and en bloc approach was performed in 39 patients (69.6%). Three patients developed postoperative complications, including hematoma, wound infection, and persistent sinus tachycardia, with no recorded deaths nor significant neurological deficits. With a mean follow-up of 38.08 (39.93) months after the surgery, 35 patients (94.6%) reported improvements in their preoperative pain, and 20 patients (54.1%) had total pain relief. Among those with preoperative neurological deficits, the recovery from sensory deficits was documented in 18 patients (66.7%), with better outcomes observed with preoperative dysesthesias rather than paresthesias, and the motor strength recovery rate was 83.3%. Two patients developed new sensory deficits, whereas no new motor deficits were reported. Tumor recurrence was reported in 1 patient (1.8%).

CONCLUSION:
Brachial plexus tumors can be cured surgically by gross total resection with favorable outcomes, minimal complications, and low incidence of recurrence.
Citrulline: A Multifunctional Compound for Health, Performance, and Therapeutic Applications
Authors: Mycyk Marcin , Cioch Michał Jakub , Kaczmarska Urszula , Woźniak Aleksandra , Nowak Julia , Hermanowicz Kamil , Doman Katarzyna , Najdek Agnieszka , Oleksy Daria , Komada Dawid 
Published: February 2025

Introduction:L-citrulline, a non-proteinogenic amino acid, is predominantly synthesized in the enterocytes of the small intestine, with smaller amounts produced in the kidneys, which plays a critical role in the detoxification of ammonia in the urea cycle, and serves as a precursor for nitric oxide (NO). Recent studies have highlighted citrulline's potential benefits in diverse physiological and pathological contexts, ranging from enhancing physical performance and muscle recovery to supporting cardiovascular health, mitigating endothelial dysfunction, and acting as a therapeutic agent in various health conditions.
Aim of study:The study aims to provide a comprehensive summary of current knowledge on the biochemical characteristics, physiological functions, and therapeutic potential of citrulline. Materials and methods:A comprehensive scientific literature review was conducted using the PubMed database, focusing on studies published up to 2024, reporting experimental, clinical, or in vivo data related to citrulline's synthesis, biological functions, and therapeutic applications.Conclusion:Emerging evidence highlights citrulline's potential in treating various health conditions, such as erectile dysfunction, neurodegenerative diseases, and intestinal barrier dysfunction, as well as its protective effects in hepatic failure, wound healing, and oxidative stress-related damage. These findings suggest that citrulline may serve as a multifaceted therapeutic agent, meriting further research to optimize its clinical use.
Obesity-related endocrine disorders
Authors: Kiełczewska Aleksandra , Kiełczewska Anna , Szcześniak Grzegorz 
Published: February 2025

Introduction and Purpose: Several endocrine disorders, including diabetes, insulinoma, Cushing syndrome, hypothyroidism, polycystic ovarian syndrome, and growth hormone deficiency, are associated with obesity. The mechanisms underlying the development of obesity vary according to the abnormalities of endocrine function. This review examines the hormonal disturbances linked to obesity, extending beyond just diabetes. It explores the prevalence, clinical features, screening, diagnosis, and management of these related conditions.
Materials and Methods: A comprehensive survey of articles published in scientific journals was conducted via PubMed and Google Scholar online research platforms. Articles were searched by entering keywords in the appropriate configuration: “obesity,” “hypothyroidism”, “hypercortisolism”, “hypogonadism” and “PCOS”.
Description of current knowledge: Prediabetes and diabetes are the most frequently encountered endocrine conditions by physicians and endocrinologists. Other common endocrine disorders seen in specialty clinics include hypothyroidism, Cushing's syndrome, androgen excess in women, and hypogonadism in men.
Summary: With our expanding knowledge of obesity, it is vital to acknowledge the influential role of fat cells in hormone synthesis. Physicians caring for obese patients should adopt a meticulous approach, screening for hormonal imbalances beyond just diabetes, to ensure comprehensive patient management.
Do Painted Nails Increase Bacterial Transmission in Healthcare Environments? A Literature Review
Authors: Brudniak Katarzyna , Garbino Karolina , Czyczerska Magdalena , Szuścik Antoni , Gadżała Katarzyna , Przygodzka Sabina , Mach Maciej , Rutkiewicz Maciej 
Published: February 2025

Introduction: Healthcare-associated infections (HAIs) continue to be a significant global concern, leading to increased patient morbidity, prolonged hospitalizations, and elevated healthcare costs. Hand hygiene remains the most critical part of infection prevention, however the use of nail polish and artificial nails has raised questions regarding their possible contribution to bacterial transmission.
Aim of study :The aim of this study is to collect and examine whether painted nails significantly influence bacterial spread in healthcare settings, focusing on nail surface properties, hand hygiene practices and existing guidelines.
Materials and Methods: A literature review was conducted with PubMed and other medical databases using appropriate keywords. Data from clinical trials and reviews were analyzed.
Conclusions: Intact nail polish does not pose a significant risk for bacterial transmission in healthcare environments when proper hand hygiene protocols are followed. Emphasis should remain on keeping short, clean nails and adhering to strict hand hygiene practices to reduce healthcare-associated infections (HAIs).
Keywords: nail polish, hand hygiene, healthcare-associated infections, articial fingernails in a hospital environment
The Impact of a Sauna on Post-Exercise Recovery
Authors: Dębicki Filip , Grądalski Łukasz , Niemirka Szymon , Janiak Aleksandra , Dominiczak Kinga , Kopaczyńska Adrianna , Szafrańska Katarzyna 
Published: February 2025

Regeneration of the body after intense exercise is a key element necessary for the proper process of improving performance and achieving better results in strength training. One of the most important issues in any athlete is the uninterrupted continuation of training and the most optimal regeneration of tissues and the body, which is essential for further improvement of skills and development in a given sport. There are a number of methods to support the repair processes of tissues and help the body fight injuries and micro-injuries that occur during exercise and are an indispensable part of building strength and muscle mass. An example that has recently become very popular in the sports environment is the use of saunas characterized by thermal properties, through which it is possible to influence physiological processes that accelerate the return to form and achieve better results in sports competitions. This form not only helps tissue regeneration, but also relaxes and calms the body, which is stimulated during sports and requires calming afterwards.
Depression in Athletes: From Etiology to Intervention
Authors: Spychalski Jan , Spychalska Maria 
Published: February 2025

Introduction: Depression is the leading cause of ill health and disability worldwide. It’s affecting approximately 280 million people across the globe with the highest rate between 20 and 40. It’s estimated that women are diagnosed twice as many times as men. Ethology is complex and multifactorial including genetic, psychological, social, endocrine, and immune factors, which results in abnormal biochemical changes and incorrect neurotransmission in the brain. Recent data points that physical activity reduces the risk of depression and its associated symptoms regardless of age or geographical location.
Aim of the study: The aim of this study is to analyze the available literature to examine the prevalence of depression among athletes and the unique risk factors contributing to it.
Materials and methods: Comprehensive review of the literature available on PubMed, Google Scholar, Scopus database by searching the keywords “depression”, “depressive disorder”, “physical activity”, “sport”, “athletes “.
Results and conclusion: Athletes are just as susceptible to depression as the general population. However, many athletes hide their symptoms and do not seek help due to stigma, fears of career repercussions and concerns about being perceived as weak. Regular screening for early signs of depression and providing access to specialized psychological support during critical stages of their careers could significantly improve depression detection and facilitate timely intervention. Destigmatizing mental health problems in the sports community is crucial to solve detection, treatment and prevention problems of depression in athletes.
Hepatoerythropoietic porphyria with coexisting BTD and CNGB1 genetic mutations: a first case report
Authors: Kaya Çağdaş , Heydari Ayli , Kızılay Oğuz , Kızılay Ozan , Sezgin Gülbüz 
Published: February 2025

Introduction: Hepatoerythropoietic porphyria (HEP) is an uncommon autosomal recessive disorder marked by deficiencies in enzymes involved in heme biosynthesis. This results in the build-up of porphyrins and their precursors. Here, we describe a case study of a 17-year-old male who has experienced symptoms of porphyria since early childhood. Case description: The patient exhibited initial symptoms of porphyria, including dark-coloured urine, abdominal pain, constipation and cutaneous lesions. Genetic testing at age 17 confirmed a homozygous mutation in the UROD gene, diagnosing HEP. Additional mutations in the CNGB1 and BTD genes contributed to retinitis pigmentosa and biotinidase deficiency, respectively. The patient also experienced complications such as thumb amputation and finger developmental anomalies. Conclusion: This case underscores the diagnostic challenges and multidisciplinary management required for patients with complex genetic profiles and rare porphyria subtypes such as HEP. Further research is essential to enhance understanding and treatment strategies for such intricate genetic conditions.
EDUCAÇÃO INFANTIL E SUAS POÉTICAS
Authors: Butzke Ítalo , Regina de Oliveira Camargo Andréia 
Published: February 2025

Uma das funções iniciais das escolas era preparar as crianças para a vida laboral, por isso, comumente seguiam um processo de aprendizagem com início, meio e fim, com o intuito de entregar um produto ao final dos ciclos, que por vezes não era pensado pelas crianças. Essa cronologia adultocêntrica e mercadológica também não respeitava o tempo e a especificidade dos bebês e crianças, pois impunha a visão do adulto, com suas verdades e realidade, fornecendo uma educação pronta, por meio da prática bancária (FREIRE, 2019). Em um fluxo reflexivo, fizemos um estudo de caso, a partir de um relato do projeto investigativo realizado com os/as bebês (1 e 2 anos) de uma escola federal, localizada no centro da cidade de São Paulo. Para isso, dialogamos com Salles (1998; 2017), Welfort (2003) e demais autoras/es que refletem e relatam experiências nas escolas italianas da região de Reggio Emilia, nos debruçamos nos projetos poéticos investigativos, termo que pretendemos cunhar neste artigo, e nos percursos criativos na Educação Infantil, com a seguinte pergunta motriz: o que estamos fazendo, criando e construindo na escola da primeira infância? Além disso, expomos nossas inquietações e reflexões em torno do tema. Vale dizer, no entanto, que não pretendemos entregar conclusões para tal pergunta, mas manter o fluxo dessas reflexões.
Treatment heterogeneity of water, sanitation, hygiene, and nutrition interventions on child growth by environmental enteric dysfunction and pathogen status for young children in Bangladesh
Authors: Butzin-Dozier Zachary , Ji Yunwen , Coyle Jeremy , Malenica Ivana , Rogawski McQuade Elizabeth T. , Grembi Jessica Anne , Platts-Mills James A. , Houpt Eric R. , Graham Jay P. , Ali Shahjahan , Rahman Md Ziaur , Alauddin Mohammad , Famida Syeda L. , Akther Salma , Hossen Md. Saheen , Mutsuddi Palash , Shoab Abul K. , Rahman Mahbubur , Islam Md. Ohedul , Miah Rana , Taniuchi Mami , Liu Jie , Alauddin Sarah T. , Stewart Christine P. , Luby Stephen P. , Colford Jr. John M. , Hubbard Alan E. , Mertens Andrew N. , Lin Audrie 
Published: February 2025

Background
Water, sanitation, hygiene (WSH), nutrition (N), and combined (N+WSH) interventions are often implemented by global health organizations, but WSH interventions may insufficiently reduce pathogen exposure, and nutrition interventions may be modified by environmental enteric dysfunction (EED), a condition of increased intestinal permeability and inflammation. This study investigated the heterogeneity of these treatments’ effects based on individual pathogen and EED biomarker status with respect to child linear growth.

Methods
We applied cross-validated targeted maximum likelihood estimation and super learner ensemble machine learning to assess the conditional treatment effects in subgroups defined by biomarker and pathogen status. We analyzed treatment (N+WSH, WSH, N, or control) randomly assigned in-utero, child pathogen and EED data at 14 months of age, and child HAZ at 28 months of age. We estimated the difference in mean child height for age Z-score (HAZ) under the treatment rule and the difference in stratified treatment effect (treatment effect difference) comparing children with high versus low pathogen/biomarker status while controlling for baseline covariates.

Results
We analyzed data from 1,522 children who had a median HAZ of −1.56. We found that fecal myeloperoxidase (N+WSH treatment effect difference 0.0007 HAZ, WSH treatment effect difference 0.1032 HAZ, N treatment effect difference 0.0037 HAZ) and Campylobacter infection (N+WSH treatment effect difference 0.0011 HAZ, WSH difference 0.0119 HAZ, N difference 0.0255 HAZ) were associated with greater effect of all interventions on anthropometry. In other words, children with high myeloperoxidase or Campylobacter infection experienced a greater impact of the interventions on anthropometry. We found that a treatment rule that assigned the N+WSH (HAZ difference 0.23, 95% CI (0.05, 0.41)) and WSH (HAZ difference 0.17, 95% CI (0.04, 0.30)) interventions based on EED biomarkers and pathogens increased predicted child growth compared to the randomly allocated intervention.

Conclusions
These findings indicate that EED biomarkers and pathogen status, particularly Campylobacter and myeloperoxidase (a measure of gut inflammation), may be related to the impact of N+WSH, WSH, and N interventions on child linear growth.
Spatio-temporal analysis of human brucellosis distribution in Neyshabur, Iran from 2015 to 2022, a cross-sectional study
Authors: Fathabadi Ayoub , Khorashadizadeh Fatemeh , Darrudi Reza , Maroosi Mohammad 
Published: February 2025

Background
Human brucellosis is a global endemic disease and a significant public health concern. This cross-sectional study aims to explore the characteristics of human brucellosis, as well as its spatial and temporal clustering.

Methods
This cross-sectional study analyzed the population infected with human brucellosis in Neyshabur, Iran from 2015 to 2022. Data were obtained from the Neyshabur health center. Spatial analysis was conducted using Anselin Local Moran’s I and Global Moran’s I with ArcGIS 10.8.2. Descriptive statistical analyses were performed using SPSS 26.

Results
During the study period, a total of 4568 brucellosis patients were reported. The incidence of disease was higher in men with 55.37%. The majority of patients belonged to the 30 to 39-year-old age group. Temporal clustering analysis revealed a peak incidence between March and June. The highest incidence rates were observed in spring and summer, with 34.76% and 33.84% of cases, respectively. Spatial clustering analysis indicated a higher prevalence in the southern and southeast districts of Neyshabur. The results of Global Moran’s I analysis indicated that the distribution of brucellosis was not clustered in Neyshabur (P-value > 0.05).

Conclusion
The findings of this study highlight the importance of educational programs for mothers and animal vaccination strategies, particularly in the months leading up to the peak brucellosis season in high-incidence areas. Further research is needed to assess the coverage of livestock vaccination and its impact on human brucellosis rates.
Mean platelet volume as a biomarker for liver fibrosis in patients with Non-alcoholic fatty liver disease
Authors: Cho Eun Hye , Kim Jee Ah , Park Min-Seung , Kwon Min-Jung , Park Hyosoon , Woo Hee-Yeon 
Published: February 2025

Introduction
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide. Accurate assessment of liver fibrosis is essential for the prognosis and management of NAFLD. Mean platelet volume (MPV), an index of platelet activation, has been associated with liver fibrosis in various chronic liver diseases; however, its role in NAFLD remains uncertain.

Methods
This study analyzed data from 70,830 patients with NAFLD who underwent a comprehensive health examination between 2015 and 2019. Patients were stratified into three groups based on the fibrosis-4 (FIB-4) index: low (<1.30), indeterminate (1.30–2.67), and high (>2.67). We evaluated the differences in MPV among these groups and analyzed the association between MPV and the FIB-4 index.

Results
MPV varied significantly across the three groups categorized by the FIB-4 index (p < 0.001). Additionally, a weak but statistically significant positive correlation was observed between MPV and the FIB-4 index (rho =  0.170, p <  0.001). Multivariable linear regression adjusted for multiple covariates showed that MPV remained significantly associated with the FIB-4 index (β =  0.01, p <  0.001).

Conclusions
MPV may serve as a supplementary non-invasive marker for assessing liver fibrosis in patients with NAFLD. Further studies are required to validate these findings and explore the utility of MPV in conjunction with other non-invasive markers.
Temporal dynamics in laboratory medicine: cosinor analysis and real-world data (RWD) approaches to population chronobiology
Authors: Marques-Garcia Fernando , Martinez-Bravo Cristina , Tejedor-Ganduxe Xavier , Fossion Ruben 
Published: February 2025

Abstract

Objectives
Chronobiology is the science that studies biological rhythms based on direct methods and empirical time series of individual subjects. In laboratory medicine, the factor of time is often underestimated, and no methods currently exist to study biological rhythms in population databases of point-like, real-world data (RWD).

Methods
Retrospective databases (24 months, 2022–2023) were extracted for four measurands (sodium, potassium, chloride and leukocytes) from the emergency laboratory. Two different strategies for data grouping were applied: data clouds (with or without outliers) and population-averaged profiles. Cosinor regression analysis was performed on the grouped data to derive circadian parameters. The parameters obtained here were compared to results from the literature, using direct methods and time series.

Results
A total of 409,719 data points were analyzed. All measurands exhibited symmetrical data distributions, except for leukocytes. The data clouds did not visually display rhythmicity, but cosinor analysis revealed a significant circadian rhythm. The removal of outliers had minimal impact on the results. In contrast, population-averaged profiles showed visible rhythmicity, which was confirmed by cosinor analysis with a better goodness-of-fit compared to the data clouds.

Conclusions
Population-averaged profiles have advantages over data clouds in characterizing circadian rhythms and deriving circadian parameters. Population chronobiology, based on RWD, is presented as an alternative to classical individual chronobiology, based on time series and overcomes the limitations of direct methods. Utilizing RWD provides new insights into the relationship between chronobiology and clinical laboratory practice.
Is it feasible for European laboratories to use SI units in reporting results?
Authors: Zaninotto Martina , Agnello Luisa , Dukic Lora , Šálek Tomáš , Linko-Parvinen Anna , Kalaria Tejas , Vermeersch Pieter 
Published: February 2025

Abstract
The ultimate goal of harmonization, crucial to quality in laboratory medicine, is to improve patient outcomes by providing accurate, actionable laboratory information. Patients and healthcare professionals assume that clinical laboratory tests performed by different laboratories at different times on the same type of sample are comparable, and that results can be reliably and consistently interpreted. In this context the reporting units for tests can have a considerable influence on the numeric result. The harmonization of measurement units in laboratory report, leads to the provision of interchangeable and comparable results, thus maximizing the validity of laboratory information, and assuring a more accurate diagnosis and better treatment for the patient. However, although considerable efforts have been made in recent years, the criticisms continue. This opinion paper, prepared jointly by EFLM Committee Harmonization (C-H) and Committee Postanalytical phase (C-POST), describes the “general pragmatic approach” proposed in the drafting of guidelines for the harmonization of measurement units in reporting results, in order to ensure they are used as widely as possible.
Thermoelastic interactions in functionally graded materials without energy dissipation
Authors: Alqahtani Zuhur , Abbas Ibrahim , El-Bary Alaa A. , Almuneef Areej 
Published: February 2025

Abstract
This study addresses the problem of thermoelastic interaction in functionally graded isotropic unbounded media owing to a timed pulse within the framework of generalized thermoelastic theory without energy dissipation (TEWOED). Functionally graded material (FGM, or material with spatially variable material characteristics) has its governing equations for the generalized thermoelastic model without energy dissipation (GNII) developed. These formulations are expressed in terms of Laplace transforms. The analytical solutions in the transform’s domain are obtained through the eigenvalues technique. The Laplace transforms are inversed using numerical methods. Finally, the acquired data are visually illustrated to illustrate how inhomogeneity, laser intensity, and laser pulse length affect displacement, temperature, and stress.