bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Satisfaction Is Equivalent Using Telemedicine Versus Office-Based Follow-up After Arthroscopic Meniscal Surgery
Authors: Herrero Christina P. , Bloom David A. , Lin Charles C. , Jazrawi Laith M. , Strauss Eric J. , Gonzalez-Lomas Guillem , Alaia Michael J. , Campbell Kirk A. 
Published: March 2021

Background:
Telemedicine has increasingly been considered as a viable alternative to traditional office-based health care, including postoperative follow-up visits. The purpose of the present study was to determine if patient satisfaction with overall care is equivalent for telemedicine follow-up (i.e., synchronous face-to-face video) and office-based follow-up after arthroscopic meniscectomy and repair.

Methods:
Patients were prospectively enrolled from August 1, 2019, to March 1, 2020. Patients were included who were ≥18 years old, consented to isolated arthroscopic meniscal repair or meniscectomy, and were able to properly utilize telemedicine software on a computer, tablet, or smartphone with a built-in camera. Patient demographic data, including complication events and postoperative satisfaction data, were recorded and analyzed for significance.

Results:
One hundred and fifty patients were enrolled in the study, of whom 122 (81.3%) were included in the final analysis. There were no significant differences between groups in terms of patient demographics or satisfaction scores. Patient satisfaction with overall care was equivalent based on the results of two 1-sided t-test analysis for equivalence (9.77 ± 0.60 in the office-based group versus 9.79 ± 0.53 in the telemedicine group; p < 0.001). When patients were asked to indicate their preferred follow-up type with the options listed as the type they received versus an alternative, 58 patients (84.1%) in the office-based group preferred their received type of follow-up, whereas 42 (79.2%) in the telemedicine group preferred their received follow-up (p = 0.493). There were no significant differences between groups in terms of complications (p > 0.05).

Conclusions:
The present study showed that patient satisfaction with overall care is equivalent between telemedicine and office-based follow-up in the immediate postoperative period following an arthroscopic meniscal surgical procedure, and should be considered a reasonable alternative to the traditional in-office modality.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Monitoring of Rainfall and Soil Moisture at the Rebaixader Catchment (Central Pyrenees)
Authors: Oorthuis RaüL , Hürlimann Marcel , Abancó Clàudia , Moya José , Carleo Luigi 
Published: March 2021

ABSTRACT
The instrumental monitoring of torrential catchments is a fundamental research task that provides necessary information to improve our understanding of the mechanisms of debris flows. While most monitoring sites include meteorological sensors and analyze the critical rainfall conditions, very few contain soil moisture measurements. In our monitoring site, the Rebaixader catchment, 11 debris flows and 24 debris floods were detected during the last 9 years. Herein, the initiation mechanisms of these torrential flows were analyzed, focusing on the critical rainfall conditions and the soil water dynamics. Comparing the temporal distribution of both rainfall episodes and torrential flows, the Kernel density plots showed maximum values for rainfalls at the beginning of June, while the peak for torrential flows is on July 20. Thus, the antecedent rainfall, and especially the soil moisture conditions, may influence the triggering of torrential flows. In a second step, a new updated rainfall threshold was proposed that included total rainfall duration and mean intensity. The analysis of soil moisture data was more complicated, and no clear trends were observed in the data set. Therefore, additional data have to be recorded in order to quantitatively analyze the role of soil moisture on the triggering of torrential flows and for the definition of thresholds. Some preliminary results show that the soil moisture at the beginning of a rainfall event affects the maximum increase of soil moisture, while a slight trend was visible comparing the initial soil moisture with the necessary rainfall amount to trigger a torrential flow.
A New Indicator of the Maturity of Organic Matter from Domanik Deposits
Authors: Burdel’naya N.S. , Bushnev D.A. 
Published: March 2021

Abstract
—Study of the aromatic fraction of Late Devonian oils and organic matter from domanik deposits of the Timan–Pechora petroleum province has revealed compounds whose proportion depends on the degree of OM transformation, namely, 1,1,7,8-tetramethyl-1,2,3,4-tetrahydrophenanthrene (1,1,7,8-TMHP) and 1,2,8-trimethylphenanthrene (1,2,8-TMP). It has been established that 1,1,7,8-TMHP dominates over 1,2,8-TMP in the immature OM; as the thermal maturation of OM increases, 1,2,8-TMP begins to prevail. The same pattern is observed for the Late Devonian oils. An increase in the ratio of 1,2,8-TMP to 1,1,7,8-TMHP with the growing thermal maturation of OM and the transition of one compound into another permit using this ratio as an additional indicator of OM maturity in domanik rocks.
The Relationship between Powerful Geodynamic Impacts and an Increase in the Mercury Content of the Water of the Angara River Source (Baikal Rift Zone)
Authors: Klyuchevskii A.V. , Grebenshchikova V.I. , Kuz’min M.I. , Dem’yanovich V.I. , Klyuchevskaya A.A. 
Published: March 2021

Abstract
—The results of Hg content determination in the water of the Angara River source are considered in relationship with the seismic processes proceeding at different levels of the lithosphere in the Baikal Rift Zone (BRZ), the geodynamic rejuvenation of the South Baikal rifting attractor structure (RAS), and the time distribution of M ≥ 7 earthquakes which occurred at a significant distance from the water sampling station. The correlation coefficients calculated between the pairs Hg content–earthquake numbers n and Hg–logarithm of summary seismic energy lgΣES are most often low, thus indicating the absence of a statistically meaningful relationship between the remote seismic process and the dynamics of mercury release. However, the correlation coefficients in the vicinity of the Angara River source are high, thus proving the relationship of the mercury release with the deformation of this territory. The statistical validity of the «deformation–mercury release» cause-and-effect relationship is verified by the fact that strong geodynamic impacts precede all meaningful Hg release maxima. In the period 1997–1998, the South Baikal RAS produced the highest impact, being in the phase of the maximum geodynamic activity. The combined impact of the RAS and the South Baikal earthquake of 1999 resulted in a series of the maximum mercury contents within 1999–2000. The subsequent gradual relaxation of the RAS activity led to a reduction in the average annual Hg content. Remote M ≥ 7 earthquakes and close strong earthquakes of the BRZ are responsible for the significant Hg release maxima. The predicted trend of the average annual Hg contents is their considerable increase in the fields of fluid discharge of faults under the powerful geodynamic impact of the RAS or strong earthquake. We assume that in the study lithosphere area, the powerful geodynamic impact caused an opening of fault zones leading to decompression with boiling and degassing of mercury and its rapid rise to the surface.
Solids-Free Loss-Control System Enables Efficient Coiled Tubing Workover Operations: Case Studies in Ukraine
Authors: Pytko Mykhailo , Kuchkovskyi Pavlo , Abdellaitif Ibrahim , Franco Delgado Ernesto , Vyslobitsky Andriy , Balabatyr Yerik , Rachid Haro Raul German , Ahmim Nacer Ridha , Garcia Cardona Walther 
Published: March 2021

Abstract
This paper describes three coiled tubing (CT) applications in depleted reservoir wells, where full circulation and precise fluid placement were achievable only by using a novel solids-free loss-control system, such as abrasive perforating applications. It also describes the preparation work, such as laboratory results and mixing procedure performed to ensure successful implementation.
The analysis of Ukrainian reservoir conditions by local and global engineering teams showed that in a highly depleted well, abrasive jetting through CT was the best option to efficiently perforate the wellbore. However, this approach could lead to later impairment of the gas production if the abrasive material (sand) could not be entirely recovered. Such a risk was even higher as wells were depleted and significant losses to the formation occurred. The use of solids-free fluid-loss material that was easy to mix, pump, and remove after the operation, was, therefore, critical to the success of that approach.
In Ukraine, most of the brownfields have a reservoir pressure that varies between 50% and 20% of the original reservoir pressure. This is a challenge for CT operations in general and especially for abrasive jetting, which requires full circulation to remove solids. It also complicates intervention when precise fluid placement control is required, such as spotting cement to avoid its being lost into the formation.
The perforation solids-free loss-control system is a highly crosslinked Hydroxy-Ethyl Cellulose (HEC) system designed for use after perforating when high-loss situations require a low-viscosity, nondamaging, bridging agent as is normally required in sand control applications. It is supplied as gel particles that are readily dispersed in most completion brines. The particles form a low-permeability filter cake that is pliable, conforms to the formation surface, and limits fluid loss. The system produces low friction pressures, which enable its placement using CT. Introduction of that system in Ukraine allowed the full circulation of sand or cuttings to surface without inducing significant damage to the formation for first time; it was also used for balanced cement plug placements.
This project was the first application of the solids-free loss-control system in combination with CT operations. It previously was used only for loss control material during the well completion phase in sand formations with the use of drilling rigs.
Application of Finite Element Method in Coiled Tubing Services
Authors: Yekta Kaveh 
Published: March 2021

Abstract
The recent development in commercialization and simplification of advanced simulating software provides a unique tool for analysis of different challenges in the oil and gas industry. These commercial packages are designed to be user-friendly and yet be able to perform complex simulations. For a very long time, working with such simulating software required a unique skill set. The enhanced user-interface and different visual aid improved the quality of simulator programs and reduced the level of difficulty of using those programs. Applying such simulating capabilities makes it possible for a better understanding of a vast array of challenges and problems in Coiled Tubing (CT) Services. Building a three-dimensional (3D) model for stress and vibration analysis to simulate the real operational problem is among the advantages of using such a program.
The finite element method (FEM) is the mathematical tool that is used in the commercial simulating software. The FEM provides a linear and nonlinear analysis option to solve different types of mechanical problems. The common outputs for such analysis are stress, displacement, and vibration modes. A real-life example of a failed dimple connector due to excessive force was simulated to find the stress and displacement of a specific grade of pipe. In the other case, the impact of vibration of the CT stack on wellhead was simulated and analyzed. The structural analysis of two main components of Coiled Tubing surface equipment such as Gooseneck and CT Reel subjected to actual loads were modeled using FEM.
The simulation of each case provides critical information that could not be achieved by any other means due to the complex geometry of the problem in some cases. In each case, the FEM simulation program provides essential information such as stress, vibration mode, and displacement. This information can be used to optimize the design and enhancement of the operating envelope of each case in the well intervention operation.
Using the FEM/3D modeling package provides a tool to evaluate and explore the different impacts of loads on CT surface equipment. Utilizing such programs in different applications such as CT, intervention, and completions can be a reliable tool during design, execution, and failure analysis process. Using analytical simulators could replace costly physical testing. On the occasion that the physical testing is required, using the simulated results could optimize the better planning of utilization of sensors for a different position. There are more types of simulations available within these packages, such as fatigue modeling, nonlinear analysis, transient, and impact analysis.
Using Distributed Fibre Optic Sensing to Recover Well Integrity and Restore Production
Authors: Noble Lilia , Rees Hugh , Langnes Tommy , Thiruvenkatanathan Pradyumna 
Published: March 2021

Abstract
Subject North Sea oil producing well has developed sustained casing pressure in the A-annulus, resulted in well being shut-in for around 3 years. Several attempts were made to understand the source of the tubing-to-annulus communication, however remediation actions based on the conventional intervention techniques were not successful, leak location was not isolated and sustained annular pressure remained. This resulted in deferral of oil production and costs incurred due to unsuccessful intervention and remediation techniques.
As the well was already equipped with the permanent fibre optic cable for the communication with the downhole pressure gauge, an alternative opportunity was taken to detect leak location by repurposing the cable for the use of Distributed Acoustic Sensing (DAS) technology along with latest pattern recognition techniques. This approach is based on decoupling of fluid movement signature from the background noise and use pattern recognition algorithms to construct fluid flow logs across entire length of the fibre, displaying character and evolution of fluid noise through depth and time.
Performed acquisition program allowed to activate the leak, presence of which was clearly visible on the wellhead and A-annulus pressure data. DAS-based acoustic flow logs allowed to clearly identify the exact location of the leak points and additionally provided an understanding to the reasons of failure of remediation methods based on the interpretation of conventional tool results.
Remediation strategy based on the insights provided by DAS succeeded to isolate leak points with no further pressure build-up observed in the A-annulus. As a result, operator was able to return to production the well that has been shut-in for three years. This allowed to reinstate 1mbod in production, restore well primary barriers and reduce operational spend through cancellation of further well interventions.
This technology offers a new method of acoustic data processing on DAS that extracts valuable insights to identify the source of fluid flow and flow pathways, providing an ability of capturing events behind multiple casing strings.
Inhibiting the “Undruggable” RAS/Farnesyltransferase (FTase) Cancer
Target by Manumycin-related Natural Products
Authors: Silva Leandro Rocha , da Silva-Júnior Edeildo Ferreira 
Published: March 2021

:
Cancer is an uncontrolled cell growth that can generate diverse types of cancer, in which these will also present a different behavior in the face of pharmacological treatment. These cancers’ types are found in one of the three categories, leukemias (also named lymphomas), carcinomas, and sarcomas. In general, cancer's pathogenesis is associated with three genetic mutations, where could emerge from oncogenes, tumor suppressor genes, and/or genes responsible for regulating DNA replication. The term “undruggable” is frequently related to the difficulty to design drugs to specific targets, such as MYC, MYB, NF-κB, and RAS family of proteins. This last comprises more than 140 proteins, and these are responsible for 30% of mutations in human cancers. Also, there are three ras genes transcribed in human cells, called H-, K-, and N-ras oncogenes. Still, the RAS proteins (farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase) enzymes) perform essential steps in post-translational modification of eukaryotes cells, such as (1) the farnesylation of the cysteine residue at the C-terminal tetrapeptide CAAX; (2) proteolytic cleavage of the three C-terminal AAX oligopeptide; and (3) carboxymethylation of the new C-terminal prenylated cysteine. Thus, the inhibition of this undruggable RAS family of proteins has been considered a promising alternative to design new anticancer agents since they are responsible for many types of human cancers. Then, the manumycin A (obtained from the Streptomyces parvulus Tü64) and its analogs (epoxyquinol core with or without their southern and eastern side chains; and dihydroxycyclohexenones core) have been described as promising FTase inhibitors, which have demonstrated their benefits against several types of cancer. In this review, a complete introduction about cancer and its relation with RAS proteins is provided, as well as, the prenylation mechanism of the cysteine residue is discussed in detail. Posteriorly, studies involving manumycin-related compounds are described, showing some synthetic routes for obtaining them and utilizing these natural products in monotherapies or combined therapies with other anticancer drugs.
Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations
Authors: Mehta Sharuti , Sharma Anil Kumar , Singh Rajesh K. 
Published: March 2021

:
Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a herbaceous plant and commonly called 'King of Bitters'. It has gained attraction as a potential hepatoprotective agent and a natural molecule with various biological activities viz. anticancer, immunomodulatory, anti-inflammatory, antibacterial, neuroprotective, and so on. The andrographolide is one of the main diterpenoids responsible for the drug's bitter taste and various therapeutic activities. The poor cellular permeability, solubility and short biological half-life of its pure components limit its distribution to the target tissue. To conquer this obstacle, various researchers worldwide have been working on designing the synthetic derivatives of its active components and nanoformulations to improve the drug's efficiency and selectivity to develop more active leads for biomedical applications. This article discussed the recent research on synthetic derivatives, including their possible therapeutic applications and structure-activity relationship (SAR). Additionally, this article also presents the essential information concerning the various nanoformulations developed to increase the delivery of pure compound/plant extract to the target site, thereby improving the drug's efficacy for multiple ailments.
Pharmacologic Activities of 5, 6-Diaryl/heteroaryl-3-substituted-1, 2, 4-
triazines as a Privileged Scaffold in Drug Development
Authors: Khatir Zahra Zakeri , Irannejad Hamid 
Published: March 2021

:
1, 2, 4-Triazine derivatives have received much attention due to their multifunctional nature,
especially in diverse pharmacological properties as well as a key fragment in many drug candidates.
Introduction of a vicinal 5, 6-diaryl/heteroaryl moiety on the 1, 2, 4-triazine ring has attracted
plentiful attention in the field of medicinal chemistry. 5, 6-Diaryl/heteroaryl-3-substituted-1, 2, 4-
triazine is a prominent scaffold in many drug candidates, which has shown a wide range of pharmacological
activities such as anti-diabetic, antifungal, anti-inflammatory, anticancer, anti-HIV, neuroprotective,
anticonvulsant, anti-Alzheimer, anti-Parkinson, and antioxidant. In this review, we have discussed
synthesis, various pharmacological activities of 5, 6-diaryl/heteroaryl-3-substituted-1, 2, 4-
triazines, their structure-activity relationship (SAR), pharmacophoric elements, and their mechanism
of action reported in the published articles during 2000-2019. Evaluation of compounds by PAINS
filtering tool was accomplished and showed that this versatile structure could be considered as a privileged
structure. Compilation of the biological data confirmed that position 3 of the 1,2,4-triazine is a
key location to determine the affinity and selectivity of the 5,6-diaryl/heteroaryl-3-substituted-1, 2, 4-
triazines towards different biologic targets. Specific geometrical and thermodynamic characters of this
motif have prompted it as a frequent hitter.
In Silico Investigations on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Terminalia bellerica
Authors: Fei Lim Chiew , Gaurav Anand , Al-Nema Mayasah 
Published: March 2021

Background:Schizophrenia is a severe mental disorder that affects around 1% of the population worldwide. The available antipsychotics alleviate the positive symptoms of the illness. However, their effect on the negative and cognitive symptoms is limited. The fruit powder of Terminalia bellerica has been found to possess antipsychotic activity, which might be useful in treating the symptoms of schizophrenia.Objective:The present study was performed to evaluate the affinity of the active constituents of Terminalia bellerica towards macromolecular drug targets involved in the pathophysiology of schizophrenia and, thereby, determine the structural features of the ligands involved in the interactions with the proposed targets.Methods:A molecular docking study was carried out on ten active constituents of Terminalia bellerica with four-drug targets involved in the aetiology of schizophrenia. These targets are dopamine, N-methyl- D-aspartate, Gamma-aminobutyric acid, and phosphodiesterase 10A receptors. The binding interactions between the target proteins and the ligands with the highest affinities were studied thoroughly.Results:β-sitosterol, ellagic acid, and quercetin displayed high binding affinity toward all the macromolecular drug targets. β -sitosterol possesses a high binding affinity for the dopamine receptor, while quercetin has high binding affinities for both dopamine and N-methyl-D-aspartate receptor. On the other hand, ellagic acid formed stronger binding interactions with Gamma-aminobutyric acid and phosphodiesterase 10A.Conclusion:Terminalia bellerica can serve as a new anti-psychotic drug from natural sources with more promising development.