bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru
Authors: Valcarcel Bryan , De-la-Cruz-Ku Gabriel , Malpica Luis , Enriquez-Vera Daniel 
Published: August 2021

Background
Previous studies have found that healthcare-associated bacteremia (HAB) by Aeromonas species is associated with mortality. However, there is limited data on this outcome in patients with hematologic malignancies. This study aimed to identify the clinical features of patients with malignant hematologic diseases diagnosed with Aeromonas sobria bacteremia and to evaluate whether the type of bacteremia, community-acquired bacteremia (CAB) or HAB, is associated with mortality.

Methods
We retrospectively reviewed the clinical records of pediatric and adult patients between January 2000 and December 2017. Clinical characteristics were compared between CAB and HAB. Additionally, we stratified based on age group. Survival outcomes were assessed with Kaplan-Meier curves and a multivariate Cox regression analysis.

Results
A total of 37 patients (median age 24 years) were identified; 23 (62%) had HAB and 14 (38%) had CAB. Overall, the most common presenting symptom was abdominal pain (41%). Acute lymphoblastic leukemia (n = 12/15, 80%) and acute myeloid leukemia (n = 8/22, 36%) were the primary hematologic malignancies in pediatric and adult patients, respectively. CAB patients had worse overall survival (OS) rates at 30 days in all (43% versus HAB 91%, p = 0.006) and adult patients (30% versus HAB 92%, p = 0.002). Cox regression analysis found that quick Sequential Organ Failure Assessment and CAB were statistically significant factors associated with mortality. Low antimicrobial-resistant was noted, except for ciprofloxacin (n = 5/37, 14%).

Conclusion
Our study found a worse OS among patients with hematologic malignancies and CAB by Aeromonas sobria. Our results suggest that patients with CAB present with a worse disease severity. These findings should aid clinicians to determine the survival prognosis in this population.
COVID-19 and cause of pregnancy loss during the pandemic: A systematic review
Authors: Kazemi Seyyedeh Neda , Hajikhani Bahareh , Didar Hamidreza , Hosseini Sareh Sadat , Haddadi Sara , Khalili Farima , Mirsaeidi Mehdi , Nasiri Mohammad Javad 
Published: August 2021

Introduction
The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19 pandemic. We aimed to conduct this systematic review to understand better the potential effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on fetal loss in infected mothers presented with abortion following this infection.

Methods
We included articles published in PubMed/Medline, Web of Science, clinicaltrials.gov, and Embase databases in 2019 and 2020 through a comprehensive search via appropriate keywords, including COVID-19 and abortion synonyms. All studies with the abortion data in COVID-19 confirmed pregnant females were collected.

Results
Out of 208 potentially relevant articles, 11 articles were eligible to include in the systematic review. The included reports were published because of the following reasons: (1) First-trimester miscarriage; (2) Late miscarriage; (3) complication of COVID-19 infection in pregnancy; (4) COVID-19 disease in artificial pregnancy. First-trimester abortion was found in 5 studies, and second-trimester abortion in 7 studies. Two patients acquired infection during the hospital stay while they were referred for abortion. Reports related to abortion in pregnant females with COVID-19 show that most miscarriages due to COVID-19 in the first trimester were due to placental insufficiency.

Conclusions
There is an increased risk of abortion in mothers with a positive test result of SARS-CoV-2, which several case reports and case series have identified during the pandemic. Placental inflammation during the viral infection may result in fetal growth retardation and induce abortion. There has not been any consistent evidence of vertical transmission of the virus from mother to fetus, which requires further investigation.
The accuracy of self-reported physical activity questionnaires varies with sex and body mass index
Authors: Quinlan Clare , Rattray Ben , Pryor Disa , Northey Joseph M. , Anstey Kaarin J. , Butterworth Peter , Cherbuin Nicolas 
Published: August 2021

Background
Factors contributing to the accurate measurement of self-reported physical activity are not well understood in middle-aged adults. We investigated the associations between two self-reported surveys and objectively measured physical activity in middle-aged adults, and the influence of individual and sociodemographic factors on these associations, at different intensities utilizing an observational study design.

Methods
Participants (n = 156) wore a SenseWear Armband™ (SWA) for a continuous seven-day period over the triceps of the left arm, to measure energy expenditure in metabolic equivalents. Participants also completed the Physical Activity Recall questionnaire (PAR) and Active Australia Survey (AAS). Associations were analyzed separately in general linear models for each intensity. The influence of individual and sociodemographic factors was assessed through moderator analyses.

Results
The PAR and SWA were significantly positively associated at moderate (β = 0.68, 95% CI 0.16–1.20), vigorous (β = 0.36, 95% CI 0.20–0.53), moderate-to-vigorous physical activity (MVPA) (β = 0.52, 95% CI 0.20–0.83), and total METmins (β = 0.63, 95% CI 0.35–0.90), the AAS and SWA were associated at all intensities (moderate (β = 0.41, 95% CI 0.15–0.67), vigorous (β = 0.32, 95% CI 0.19–0.46), MVPA (β = 0.42, 95% CI 0.18–0.65) and total METmins (β = 0.62, 95% CI 0.29–0.96). A significant interaction between the PAR and sex for vigorous-intensity unveiled a weaker association in women. Both surveys tended to under-report physical activity. The largest margins of error were present at light and moderate intensities. For the PAR, participants reported over 20 hours, or 69% less light physical activity than recorded by the SWA per week. For the AAS, participants reported over 7 hours, or 38% less moderate physical activity. Compared to lighter intensities, time spent at a vigorous intensity was overreported by participants with the PAR and AAS by 91 and 43 minutes per week, respectively. The addition of Body Mass Index (BMI) resulted in non-significant interactions between the PAR and SWA for moderate-intensity, and the AAS and SWA for vigorous-intensity; a significant interaction between AAS and BMI indicated that the strength of the association differed by BMI for vigorous-intensity.

Conclusions
The PAR and AAS are not equivalent to the SWA, and sex and BMI may alter the associations between the measures.
Leveraging omics to understand the molecular basis of acute-on-chronic liver failure
Authors: Clària Joan 
Published: August 2021

Abstract
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.
A comparison of numerical methods for model reduction of dense discrete-time systems
Authors: Jendersie Robert , Werner Steffen W. R. 
Published: August 2021

Abstract
Discrete-time systems are a common tool in the modeling of processes in many application areas such as digital signal processing and population dynamics. Model reduction is an essential remedy to handle high-fidelity systems in practice. To benefit from the performance gained by using reduced-order models, the computation of these models itself must be done with a reasonable use of resources. In this paper, we consider the case of medium-scale dense discrete-time systems and compare the performance of different numerical methods for the implementation of two basic model reduction techniques. Therefore, we give an overview of the considered model reduction methods and of the techniques used in underlying implementations. The outlined methods are then compared with established implementations in several numerical examples in terms of accuracy and performance.
Neurosurgery planning based on automated image recognition and optimal path design
Authors: Hackenberg Annika , Worthmann Karl , Pätz Torben , Keiner Dörthe , Oertel Joachim , Flaßkamp Kathrin 
Published: August 2021

Abstract
Stereotactic neurosurgery requires a careful planning of cannulae paths to spare eloquent areas of the brain that, if damaged, will result in loss of essential neurological function such as sensory processing, linguistic ability, vision, or motor function. We present an approach based on modelling, simulation, and optimization to set up a computational assistant tool. Thereby, we focus on the modeling of the brain topology, where we construct ellipsoidal approximations of voxel clouds based on processed MRI data. The outcome is integrated in a path-planning problem either via constraints or by penalization terms in the objective function. The surgical planning problem with obstacle avoidance is solved for different types of stereotactic cannulae using numerical simulations. We illustrate our method with a case study using real MRI data.
Verteilt-parametrische Modelle zur Beschreibung des nichtlinearen fraktionalen Verhaltens von Lithium-Ionen-Zellen
Authors: Tappeiner Lukas , Oldenburger Marc , Bedürftig Benjamin , Woittennek Frank 
Published: August 2021

Zusammenfassung
Es werden verteilt-parametrische Modelle hergeleitet, die das nichtlineare fraktionale Verhalten von Lithium-Ionen-Zellen beschreiben. Die vorgestellten Modelle interpolieren lineare verteilt-parametrische Kleinsignalmodelle, die sich als diffusive Realisierungen fraktionaler Übertragungsfunktionen in den Arbeitspunkten ergeben. Diese Übertragungsfunktionen werden mittels Impedanzspektroskopie parametriert. Zur endlich-dimensionalen Approximation der vorgestellten Modelle werden Krylov-Unterraum-Verfahren und Finite-Elemente-Ansätze genutzt. Diese nichtlinearen konzentriert-parametrischen Modelle werden in Simulationsstudien miteinander verglichen und anhand experimenteller Daten validiert.
Preparation and adsorption properties of Ni(ii) ion-imprinted polymers based on synthesized novel functional monomer
Authors: Zhao Li , Hu Xianzhi , Zi Futing , Liu Yingmei , Hu Deqiong , Li Peng , Cheng Huiling 
Published: August 2021

Abstract
In this study, a novel functional monomer N-(1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)acrylamide (NDTEA) was designed and synthesized, and was used to prepare Ni(ii) ion-imprinted polymers (Ni(ii)-IIPs). Sixteen kinds of Ni(ii)-IIP (Ni(ii)-IIP1–16) and corresponding non-imprinted polymers (NIP1–16) were prepared by precipitation polymerization method. After optimized condition experiment, Ni(ii)-IIP5 possessed maximum adsorption capacity and better imprinting factor under optimal experimental conditions which indicated by equilibrium adsorption experiments. The morphology and structural characteristics of Ni(ii)-IIP5 were characterized by scanning electron microscopy (SEM) and Brunauer–Emmett–Teller (BET). The adsorption selectivity of Ni(ii)-IIP5 was analyzed by ICP-OES, and the results showed that Ni(ii)-IIP5 had favorable selectivity recognition ability for Ni(ii) when Cu(ii), Co(ii), and Cd(ii) are used as competitive ions. The kinetic experiment indicated that the performance of Ni(ii) adsorption on the surface of Ni(ii)-IIP5 obeyed the pseudo-first-order model, and adsorption equilibrium was attained after 15 min. Isothermal adsorption process fitted to Langmuir and Freundlich isothermal adsorption models, simultaneously. The results showed that Ni(ii)-IIP5 prepared by using a new functional monomer had better permeation selectivity and higher affinity for Ni(ii), which also verified the rationality of the functional monomer design. At the same time, it also provided a broad application prospect for removal of Ni(ii) in complex samples.
Three-state switching cell boost converter using H-inf controller
Authors: Pati Nivedita , Panda Babita 
Published: August 2021

Abstract

This paper presents the modeling and control of a non-minimum phase dc-dc boost converter based on the three - state switching cells. In any double stage grid-connected system the converter forms an interface between the photovoltaic source and the inverter. As the control and regulation of the converter output is a vital part of penetration of renewable to grid, therefore, this paper had attempted the control of a converter topology that can reduce the current stress across its switches. But the system becomes highly unstable and complex which has been validated by predicting the limit cycle with a describing function. The Controller design is implemented after reducing the complexity of the system using the Model order reduction principle. H-inf controller being robust in nature is applied for stable and regulated output.
Vitamin supplementation as a potential adjunctive therapeutic approach for COVID-19: biological and clinical plausibility
Authors: Daei Sorkhabi Amin , Sarkesh Aila , Daei Sorkhabi Alireza , Entezari-Maleki Taher , Rashedi Jalil , Bannazadeh Baghi Hossein 
Published: August 2021

Abstract
The recent pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19) has introduced itself into the human population in the 21st century after the coronavirus diseases SARS-CoV and Middle East respiratory syndrome (MERS-CoV). Major investigations are underway worldwide in the search for pharmaceutical interventions for COVID-19 and many agents are administered in off-label routes. Several cases are under study to check or restrict clinical manifestations of COVID-19. According to the fact that the efficacy of some micro-nutrients like vitamins is proven to treat or prevent infectious diseases because of their antimicrobial and immunomodulatory activity, the potential role of vitamins in the COVID-19 treatment or prevention must be considered.
Law and Development in the United States
Authors: Lee Yong-Shik 
Published: August 2021

Abstract
Economic development is the term that has been associated with less developed countries in the Third World (“developing countries”), not the economically advanced countries (“developed countries”), such as the United States. However, the changing economic conditions in recent decades, such as the widening income gaps among individual citizens and regions within developed countries, stagnant economic growth deepening economic polarization, and an institutional incapacity to deal with these issues, render the concept of economic development relevant to the assessment of the economic problems in developed countries. In the United States, these economic problems caused a significant political consequence such as the unexpected outcome of the presidential election in 2016. This article examines the applicability of the legal and institutional approaches, which were originally adopted to stimulate economic development in successful developing countries, to the economic problems in the United States.
Behavioral response of wild mammals to pre-existing and artificial latrines of raccoon dogs in northeastern Japan
Authors: Yoshida Koharu , Saito Masayuki U. 
Published: August 2021

Abstract
In this study, we reveal the behavior of raccoon dogs and other mammals on two types of latrines: already-existing latrines in the field and artificial latrines created from the feces of a captive individual. From September to November 2019, we used camera traps at already-known (eight sites), and artificial latrines (four sites), and recorded the mammalian species that visited, their behavior types, and the duration of time spent at the latrines. Our camera traps detected eight species visits, including raccoon dogs, masked palm civets, and rodents (Muridae). In raccoon dogs, sniffing, urination, defecation, and passing were observed, and the numbers of defecation and passing occurrences were significantly higher in the already-existing latrines. The duration time of the raccoon dogs was significantly longer at the artificial latrine; however, the time decreased as days elapsed. Masked palm civets frequently visited the artificial latrines, where the number of rubbings was significantly higher. The Muridae did not differ in their proportion of foraging behavior between the two latrine types, indicating that both were used as feeding sites without distinction. The results of this study indicate that raccoon dog latrines affect not only raccoon dogs but also other mammals.
Morphological variation in bony structures of Hylaeamys seuanezi (Rodentia, Cricetidae, Sigmodontinae) in Southern Bahia, Brazil
Authors: García Franger J. , del Valle Alvarez Martín Roberto 
Published: August 2021

Abstract
Rodents of the genus Hylaeamys, are a group of cryptic species previously included in the Oryzomys capito complex. In Brazil are represented by six species, distributed in different biomes. However, the limits of their geographic distributions and taxonomy have not yet been well defined. In particular, the taxonomy for Hylaeamys seuanezi is unstable. Based on the analysis of bony structures and supported with geometric morphometric techniques, we characterize and compare the average shape from populations in four localities from Southern Bahia, Brazil. We review 145 individuals and we create morphological landmarks in skulls, mandibles, scapulae, and pelvis. In all the structures there were statistically significant differences between populations, in which the average shape from the Igrapiúna population was the most differentiated. Our results also showed differences between the pelvis of males and females, reporting for the first time sexual dimorphism for H. seuanezi. Finally, we provide a morphological diagnosis between the populations and postulate that such differences may be correlated with environmental and climatic factors that could be exerting negative pressures on H. seuanezi; as has been evidenced with other species of rodents and other mammals.
Fe2P nanorods based photothermal therapy combined with immune checkpoint inhibitors for pancreatic cancer
Authors: Liu Shanshan , He Jiawen , Song Ruixiang , Zhang Mengmeng , Huang Lianghao , Chen Jing , Wang Meng , Liu Fang , Zhou Feifan 
Published: August 2021

Abstract
Treatment of pancreatic cancer is faced with great difficulties and challenges due to high lethality and metastasis. Synergism of targeted therapy and immunotherapy has been considered as ideal strategy to both eliminate primary tumors and control metastases. For the treatment of advanced pancreatic cancer, we demonstrated a local photothermal therapy (PTT) following administration of monoclonal antibody of programmed death ligand 1 (αPD-L1). Fe2P nanorods were employed as a Fenton agent and photothermal agent, which modified with DSPE-PEG2000-Mal for improved biocompatibility and Mal mediated-antigen presentation. Under a low dose laser irradiation at 980 nm, Fe2P-PEG-Mal nanorods (NRs) mediated PTT could induce immunogenic tumor cell death that can cause dendritic cells (DCs) infiltration and maturation. In a bilateral pancreatic tumor model, the local treatment of NRs-PTT on primary tumor could cause the increased infiltration of cytotoxic T lymphocytes (CTLs) and decreased residential of M2 macrophages in untreated distal tumors. Furthermore, subsequently intervened αPD-L1 could enhance cell death triggered by CTLs in distal tumors through reversing immunosuppression. An orthotopic pancreatic tumor model was used to further confirm the therapeutic outcome. Finally, the combination of NRs based PTT and αPD-L1 based immunotherapy was able to significantly eliminate orthotopic pancreatic tumors and reduce mesentery metastases. Thus, the strategy may provide a more effective treatment for pancreatic cancer.
Monoaminergic hypo- or hyperfunction in adolescent and adult attention-deficit hyperactivity disorder?
Authors: Nikolaus Susanne , Mamlins Eduards , Giesel Frederik L. , Schmitt Dominik , Müller Hans-Wilhelm 
Published: August 2021

Abstract
Disturbances of dopamine (DA), serotonin (5-HT) and/or norepinephrine (NE) functions are implied in attention-deficit hyperactivity disorder (ADHD). However, the precise cortical and subcortical mechanisms are still not fully understood. In the present survey, we conducted a PUBMED search, which provided 37 in vivo investigations with PET and SPECT on 419 ADHD patients and 490 controls. The retrospective analysis revealed increased striatal DA transporter (DAT) in adolescent as well as adult medication-naïve and not acutely medicated patients. In acutely medicated adults, DAT was not different from controls. Midbrain DAT was normal in adults, but decreased in adolescents. Striatal D2 receptor (R) binding was normal in both adolescents (not acutely medicated) and adults (acutely medicated and not acutely medicated). In medication-naïve adults, DA synthesis was decreased in putamen and amygdala, but normal in the whole striatum and midbrain. In not acutely medicated adults, DA synthesis was reduced in putamen, whole striatum, prefrontal cortex, frontal cortex, amygdala and midbrain, whereas, in adolescents, no regional differences were observed. In adult (not acutely medicated) subjects, cingulate D1R was reduced. 5-HT transporter (SERT) binding was decreased in striatum and thalamus, but normal in midbrain, neocortex and limbic regions, whereas, in medication-naïve adults, SERT was diminished in striatum and midbrain, but normal in thalamus and neocortex. The findings suggest transient stages of synaptic DA shortage as well as DA surplus in individual brain regions, which elicit presynaptic as well as postsynaptic compensatory mechanisms, striving to attain functional homeostasis. Thereby, it remains a matter of debate, whether ADHD may be characterized by a general hypo- or hyperactivity of DA and/or 5-HT function.
„Religion – das ist etwas Unendliches! Glaube, ist etwas sehr Spezifisches.“ Eine Inselgemeinde im Spannungsfeld: religiös (un-)musikalisch?
Authors: Lewandowski Ludwig , van Rijswijk Nico 
Published: August 2021

Zusammenfassung
Im Gespräch reflektiert NvR. Hintergründe schwindender religiöser Ansprechbarkeit seiner Inselgemeinde. Man lasse sich nicht mehr auf die biblischen Texte ein, wohl gäbe es eine breite Empfänglichkeit für Mystik und Rituale ohne sich von der christlichen Botschaft ergreifen zu lassen.