bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control Over the Fracture in Carbonate Reservoirs as a Result of an Integrated Digital Stimulation Approach to Core Testing and Modeling
Authors: Yudin Alexey , Khan Abdul Muqtadir , Romanovskii Rostislav , Alekseev Alexey , Abdrazakov Dmitry 
Published: October 2021

Abstract
The oilfield industry is rapidly changing towards reduced CO2 emissions and sustainability. Although hydrocarbons are expected to remain the leading source for global energy, costs to produce them may become prohibitive unless new breakthrough in technology is established. Fortunately, the digital revolution in the IT industry continues at an accelerating pace. A digital stimulation approach for tight formations is presented, using the achievements of one industry to solve the challenges of another.
The fracture hydrodynamics and in-situ kinetics model is incorporated in the advanced simulator together with the detailed multiphysics models based on acid systems digitization, including rheology and fluid- carbonate interactions data obtained from the laboratory experiments. Digitization of fluid-rock interaction and fluid leakoff was performed using a coreflooding setup that allowed pumping concentrated acids in core samples at high-pressure/high-temperature (HP/HT) conditions. Varying the testing parameters across a broad range allowed refining the model coefficients in the simulator to obtain high accuracy in the predicted results.
The digital slot concept was used to validate physical models in an iterative experimental approach. The software proved efficient at providing validation of multiphysics models used together with advanced slurry transport in the simulator. The fine computational grid allowed accurate predictions of the fracture geometry, etched width, and channel conductivity, resulting in realistic well productivity anticipations. Since multiple fluid systems of the acid stimulation portfolio were digitized and incorporated into the simulator, it was possible to optimize complex acid fracturing designs in the real field operations that included retarded single-phase and multiphase acid systems, self-diverting viscoelastic acids, and fiber- based diverting systems. Several case studies from multiple areas and reservoirs from Caspian and Middle East areas have demonstrated extremely positive oil and gas production results with reduced acid volumes with the digital stimulation workflow compared to conventionally stimulated offset wells.
The digital stimulation workflow brings a new approach to acid fracturing optimization based on an integrated cycle in which high-resolution data from several sources are processed by powerful computing capacities. Starting from digitizing acid reactions with the core samples, through digitized rheology and particle transport in multiphysics models, an advanced numerical simulator tailors an optimum design from a number of acid system options, pumping rates, additive concentrations, and stage volumes to achieve best geometry of etched channels inside a fracture.
Development of Fracturing Fluids Based on Acrylamide Copolymers and Study of Their Physical and Technological Properties Using the Oscillatory Rheometry Methods
Authors: Kazak Maksim Vasilyevich , Panin Sergey Igorevich , Valenkov Andrei Mikhailovich , Hiliazitdzinau Tsimur Donalovich 
Published: October 2021

Abstract
This work studies the rheological properties of aqueous solutions of acrylamide copolymers. The prevailing role of elastic properties over viscous properties in predicting the proppant suspension capacity of the resulting fracturing fluid is shown. Furthermore, the potential of the use of oscillatory rheometry for studying fracturing fluid stability is demonstrated.
Multistage Hydraulic Fracturing of the Tyumen Suite Reservoirs of Em-Yogovskoye Field: Frac-Design, Practice, Results
Authors: Samoilov Mikhail Ivanovich , Astafyev Vladimir Nikolaevich , Musin Evgeny Faritovich 
Published: October 2021

Abstract
The paper describes a system of approaches to the design and engineering support of multistage hydraulic fracturing:
A method of developing multiple-option modular design of multistage hydraulic fracturing which is a tool for operational decision-making in the process of hydraulic fracturing. Building a Hydraulic Fracturing Designs Matrix when optimizing field development plans. The result was used to build decision maps for finding well completion methods and selecting a baseline hydraulic fracturing design.
The paper also describes how the systematization of approaches, methodological developments, and decision templates can help in optimizing field development by drilling directional and horizontal wells followed by multi-stage hydraulic fracturing. The sequence of events and tasks that led to the development of the methodology, as well as its potential, is briefly described.
The methodologies were developed during the execution of a hydraulic fracturing project at JK 29 reservoirs of the Tyumen Suite of Em-Yogovskoye field, after which they were applied in a number of other projects for the development of hard-to-recover hydrocarbon reserves in West Siberia.
High-Resolution and Multimaterial Fracture Productivity Calculator for the Successful Design of Channel Fracturing Jobs
Authors: Chuprakov Dimitry , Belyakova Ludmila , Glaznev Ivan , Peshcherenko Aleksandra 
Published: October 2021

Abstract
We developed a high-resolution fracture productivity calculator to enable fast and accurate evaluation of hydraulic fractures modeled using a fine-scale 2D simulation of material placement. Using an example of channel fracturing treatments, we show how the productivity index, effective fracture conductivity, and skin factor are sensitive to variations in pumping schedule design and pulsing strategy.
We perform fracturing simulations using an advanced high-resolution multiphysics model that includes coupled 2D hydrodynamics with geomechanics (pseudo-3D, or P3D, model), 2D transport of materials with tracking temperature exposure history, in-situ kinetics, and a hindered settling model, which includes the effect of fibers. For all simulated fracturing treatments, we accurately solve a problem of 3D planar fracture closure on heterogenous spatial distribution of solids, estimate 2D profiles of fracture width and stresses applied to proppants, and, as a result, obtain the complex and heterogenous shape of fracture conductivity with highly conductive cells owing to the presence of channels. Then, we also evaluate reservoir fluid inflows from a reservoir to fracture walls and further along a fracture to limited-size wellbore perforations. Solution of a productivity problem at the finest scale allows us to accurately evaluate key productivity characteristics: productivity index, dimensional and dimensionless effective conductivity, skin factor, and folds of increase, as well as the total production rate at any day and for any pressure drawdown in a well during well production life.
We develop a workflow to understand how productivity of a fracture depends on variation of the pumping schedule and facilitate taking appropriate decisions about the best job design. The presented workflow gives insight into how new computationally efficient methods can enable fast, convenient, and accurate evaluation of the material placement design for maximum production with cost-saving channel fracturing technology.
Initial Experience with Subchondral Stabilization for Bone Marrow Lesions of the Midfoot and Forefoot
Authors: Matthews Michael , Klein Erin , Weil Lowell , Sorensen Matthew , Fleischer Adam 
Published: October 2021

Abstract
Disabling foot pain is often accompanied by MRI evidence of bone marrow edema which may represent early structural fatigue. Emerging evidence suggests subchondral stabilization with injectable calcium phosphate can alleviate pain associated with bone marrow edema in the hindfoot, ankle and knee; however, there is no data supporting its use or safety for midfoot or forefoot lesions. We identified 54 patients who underwent SS of various midfoot/forefoot osseous structures in our practice over a four-year period. All patients proved recalcitrant to standard conservative measures, and all had advanced imaging appreciating BME. VAS for pain at 1, 3, 6, and 12 months postoperatively served as the primary outcome measure. 41 patients were included with a mean age of 54.3 ± 14.9 years and mean follow up of 14.1 ± 6.9 months. Patients saw a significant decrease in VAS pain as early as 1 month postoperatively (p<0.05). Mean postoperative VAS at 12 months was 2.11 ± 2.50, and the mean reduction in VAS pain from preop to 12 months postop was -5.00 (95% CI -3.44 to -6.56, p<0.05). Fourteen patients (34%, 14/41) were pain free at 12 months. Treatment of more than one bone (unadjusted OR 6.23 [95% CI 1.39 to 27.8], P=0.017) was associated with a greater likelihood of not achieving a pain free status at 12 months. Initial experience suggests that SS was both safe and effective in our patient population. Simultaneous treatment of multiple bones should be entered into with caution, and further research on the subject is necessary. Level of Evidence: IV (Retrospective Case Series)
Research on Percolation Threshold of Broadband Electromagnetic Wave Absorbing SiCN (MWCNTs) Composite Ceramics
Authors: Wang Shan , Gong Hongyu , Qi Desheng , Ashfaq M. Zeeshan , Yue Xigui 
Published: October 2021

Abstract
A simple polymer derivation method was applied in this paper to prepare a series of SiCN (MWCNTs) composite ceramics by adjusting the mass ratio of multi-walled carbon nanotubes (MWCNTs). The percolation threshold of the corresponding MWCNTs addition amount when SiCN(MWCNTs) composite ceramics exhibit the optimal electromagnetic wave (EWM) absorption performance was studied, the effect of different addition amounts of MWCNTs on reflection loss (RL), effective absorption bandwidth (EAB), electromagnetic parameters, impedance matching parameters (Z) and attenuation coefficient (α) of composite ceramics was analyzed, and the EMW absorption mechanism of the corresponding composite ceramics when MWCNTs addition amount fix at percolation threshold was discussed. The results showed that composite ceramics exhibited the best EMW absorption performance when the addition amount of MWCNTs reached the percolation threshold (10wt%): the minimum reflection loss (RLmin) was -37.9 dB, and the EAB was 2.8 GHz at a thickness of 2.4 mm; its RLmin was -21.7 dB, and the EAB reached 4.7 GHz at a thickness of 1.7 mm. By changing the sample thickness from 1.0 mm to 5.0 mm, the EAB containing the C, X and Ku bands can be acquired. Therefore, it is expected to be a promising candidate for the new generation of EMW absorbers due to its light weight, high efficiency and broad band.
Splice Junction Identification using Long Short-Term Memory Neural Networks
Authors: Regan Kevin , Saghafi Abolfazl , Li Zhijun 
Published: October 2021

Background:
Splice junctions are the key to going from pre-messenger RNA to mature messenger RNA in many multi-exon genes due to alternative splicing. Since the percentage of multi-exon genes that undergo alternative splicing is very high, identifying splice junctions is an attractive research topic with important implications.

Objective:
The aim is to develop a deep learning model capable of identifying splice junctions in RNA sequences using 13,666 unique sequences of primate RNA.

Method:
A Long Short-Term Memory (LSTM) Neural Network model is developed that classifies a given sequence as EI (Exon-Intron splice), IE (Intron-Exon splice), or N (No splice). The model is trained with groups of trinucleotides and its performance is tested using validation and test data to prevent bias.

Results:
Model performance was measured using accuracy and f-score in test data. The finalized model achieved an average accuracy of 91.34% with an average f-score of 91.36% over 50 runs.

Conclusion:
Comparisons show a highly competitive model to recent Convolutional Neural Network structures. The proposed LSTM model achieves the highest accuracy and f-score among published alternative LSTM structures.
Lactoferrin as a Potent Natural Supplement Exhibiting a Synergistic Effect
with Drugs in Antimicrobial and Anticancer Therapies
Authors: Gajda-Morszewski Przemysław , Brindell Małgorzata 
Published: October 2021

:
For many years, natural products have played a crucial role in drug discovery and drug
design as a source of active agents or as inspiration. Lactoferrin (Lf), a glycoprotein found in milk
and mammalian secretions, has been extensively studied in recent years, and numerous antimicrobial,
anti-inflammatory, and anticancer properties of Lf have been demonstrated in the literature.
The use of lactoferrin as a co-agent or supplement to enhance the beneficial effect of drugs, or to reduce
their side effects, arouses the interest of many researchers, especially since Lf is a well-studied,
biocompatible, cheap, and easily accessible protein. In this mini-review, we focus on the
elucidation of the role of Lf in antimicrobial or anticancer therapies, pointing to the possible mechanism
underlying the determined synergism between Lf and commonly used drugs.
Factors Associated With Willingness to Share Health Information: Rapid Review
Authors: Naeem Iffat , Quan Hude , Singh Shaminder , Chowdhury Nashit , Chowdhury Mohammad , Saini Vineet , TC Turin 
Published: October 2021

Background
To expand research and strategies to prevent disease, comprehensive and real-time data are essential. Health data are increasingly available from platforms such as pharmaceuticals, genomics, health care imaging, medical procedures, wearable devices, and internet activity. Further, health data are integrated with an individual’s sociodemographic information, medical conditions, genetics, treatments, and health care. Ultimately, health information generation and flow are controlled by the patient or participant; however, there is a lack of understanding about the factors that influence willingness to share health information. A synthesis of the current literature on the multifactorial nature of health information sharing preferences is required to understand health information exchange.

Objective
The objectives of this review are to identify peer-reviewed literature that reported factors associated with health information sharing and to organize factors into cohesive themes and present a narrative synthesis of factors related to willingness to share health information.

Methods
This review uses a rapid review methodology to gather literature regarding willingness to share health information within the context of eHealth, which includes electronic health records, personal health records, mobile health information, general health information, or information on social determinants of health. MEDLINE and Google Scholar were searched using keywords such as electronic health records AND data sharing OR sharing preference OR willingness to share. The search was limited to any population that excluded health care workers or practitioners, and the participants aged ≥18 years within the US or Canadian context. The data abstraction process using thematic analysis where any factors associated with sharing health information were highlighted and coded inductively within each article. On the basis of shared meaning, the coded factors were collated into major themes.

Results
A total of 26 research articles met our inclusion criteria and were included in the qualitative analysis. The inductive thematic coding process revealed multiple major themes related to sharing health information.

Conclusions
This review emphasized the importance of data generators’ viewpoints and the complex systems of factors that shape their decision to share health information. The themes explored in this study emphasize the importance of trust at multiple levels to develop effective information exchange partnerships. In the case of improving precision health care, addressing the factors presented here that influence willingness to share information can improve sharing capacity for individuals and allow researchers to reorient their methods to address hesitation in sharing health information.
A Serious Game (Immunitates) About Immunization: Development and Validation Study
Authors: Lima Isabela Dantas de Araujo , Ponce de Leon Casandra Genoveva Rosales Martins , Ribeiro Laiane Medeiros , Silva Izabel Cristina Rodrigues da , Vilela Danielle Monteiro , Fonseca Luciana Mara Monti , Góes Fernanda dos Santos Nogueira de , Funghetto Silvana Schwerz 
Published: October 2021

BackgroundVaccination is a fundamental part of all levels—local to worldwide—of public health, and it can be considered one of humanity's greatest achievements in the control and elimination of infectious diseases. Teaching immunization and vaccination can be monotonous and tiring. It is necessary to develop new approaches for teaching these themes in nursing school.ObjectiveWe aimed to develop and validate a serious game about immunization and vaccination for Brazilian nursing students.MethodsWe developed a quiz-type game, Immunitates, using design and educational theoretical models and Brazilian National Health Guidelines. The game’s heuristics and content were evaluated with 2 different instruments by a team of experts. A sample of nursing students evaluated the validity of the game’s heuristics only. We calculated the content validity index (CVI) for each evaluation.ResultsThe study included 49 experts and 15 nursing students. All evaluations demonstrated high internal consistency (Cronbach α≥.86). The game’s heuristics (experts: CVI 0.75-1.0; students: CVI 0.67-1.0) and the game’s contents demonstrated validity (experts: CVI 0.73-1.0). Participants identified some specific areas for improvement in the next version.ConclusionsThe serious game appears to be valid. It is intended as a support tool for nursing students in the teaching–learning process and as a tool for continuing education for nurses.
Contribution of the co.LAB Framework to the Collaborative Design of Serious Games: Mixed Methods Validation Study
Authors: Jaccard Dominique , Suppan Laurent , Bielser Félicia 
Published: October 2021

Background
Multidisciplinary collaboration is essential to the successful development of serious games, albeit difficult to achieve. In a previous study, the co.LAB serious game design framework was created to support collaboration within serious game multidisciplinary design teams. Its use has not yet been validated in a real usage context.

Objective
The objective of this study was to perform a first assessment of the impact of the co.LAB framework on collaboration within multidisciplinary teams during serious game design and development.

Methods
A mixed methods study was conducted, based on 2 serious game design projects in which the co.LAB framework was used. The first phase was qualitative and carried out using a general inductive approach. To this end, all members of the first serious game project team who used the co.LAB framework were invited to take part in a focus group session (n=6). In a second phase, results inferred from qualitative data were used to define a quantitative instrument (questionnaire) that was designed according to the Checklist for Reporting Results of Internet E-Surveys. Members of both project teams (n=11) were then asked to answer the questionnaire. Quantitative results were reported as median (Q1, Q3), and appropriate nonparametric tests were used to assess between-group differences. Finally, results gathered through the qualitative and quantitative phases were integrated.

Results
In both phases, the participation rate was 100% (6/6 and 11/11). Verbatim transcripts were classified into 4 high level themes: (1) influence on collaborative dimensions; (2) impact on project course, monitoring, and efficiency; (3) qualitative perceptions of the framework; and (4) influence of team composition on the use of the framework. The web-based questionnaire was then developed according to the 7 dimensions of collaboration by Burkhardt et al. In both projects, the co.LAB framework had a positive impact on most dimensions of collaboration during the multidisciplinary design and development of serious games. When all collaborative dimensions were aggregated, the overall impact of the framework was rated on a scale from –42 to 42 (very negative to very positive). The overall median score was 23 (Q1, Q3: 20, 27), with no significant difference between groups (P=.58). Most respondents also believed that all serious game design teams should include a member possessing significant expertise in serious game design to guide the development process.

Conclusions
The co.LAB framework had a positive impact on collaboration within serious game design and development teams. However, expert guidance seems necessary to maximize development efficiency. Whether such guidance can be provided by means of a collaborative web platform remains to be determined.
THE THE FIRST DOCUMENTED PREY ITEMS FOR Bothrops medusa (STERNFELD, 1920)
Authors: Schramer Tristan David 
Published: October 2021

The Venezuelan forest pitviper (Bothrops medusa) is an endangered viperid endemic to the central range of the Cordillera de la Costa in Venezuela. Little is known regarding its natural history. We examined the stomach contents of museum specimens housed in the University of Illinois Museum of Natural History Herpetology Collection and report the first prey items for the species. The arboreal habits of both prey items support the notion that B. medusa may be semi-arboreal. This exposes the need for further studies on this rare viperid and showcases the value of natural history collections for studying endangered species.
Neuroimaging referral for reassurance in evaluation of headache with low-risk features
Authors: Fernandez Omar E. 
Published: October 2021

A clinical decision report using:
Howard L, Wessely S, Leese M, et al. Are investigations anxiolytic or anxiogenic? A randomised controlled trial of neuroimaging to provide reassurance in chronic daily headache. J Neurol Neurosurg Psychiatry. 2005;76(11):1558-1564. https://doi.org/10.1136/jnnp.2004.057851
for a patient with daily headache.
Using a single tablet regimen of darunavir, cobicistat, emcitrabine, and tenofovir alafenamide in virally suppressed HIV-1 patients is an adequate treatment option for controlling HIV
Authors: Kathuria Priya 
Published: October 2021

A clinical decision report using:
Orkin C, Molina JM, Negredo E, et al. Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically suppressed HIV-1 (EMERALD): a phase 3, randomised, non-inferiority trial. Lancet HIV. 2018;5(1):e23-e34. https://doi.org/10.1016/S2352-3018(17)30179-0
for a patient with viriologically suppressed HIV-1.
Personal development of future economists through professional education
Authors: Kalyakina Inessa Makedonovna , Filippova Olga Vladimirovna , Sorgutov Ilya Valerievich , Ignatyeva Olga Valeryevna , Grigoriev Alexander Vladimirovich , Rodionov Stanislav Sergeevich 
Published: October 2021

The article examines the peculiarities of the personality development of future economists through professional education. The authors note that it is the personal aspects that play a leading role in the formation of professional identity, since the level of professional training of specialists in the field of economics involves constant self-development and self-improvement. Effective use should also bridge the gap between these stakeholders by establishing partnerships to optimize the coverage of competencies among employees of economic universities by region, specialty, type of employer and career stages. In this regard, it should be said that the professional competencies of economists are directly related to the development of their personality, which will allow them to receive a comprehensively trained and valuable specialist in all respects in the future.