bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of face masks on performance and cardiorespiratory response in well-trained athletes
Authors: Egger Florian , Blumenauer Dominic , Fischer Patrick , Venhorst Andreas , Kulenthiran Saarraaken , Bewarder Yvonne , Zimmer Angela , Böhm Michael , Meyer Tim , Mahfoud Felix 
Published: June 2021

Abstract
Background
During the COVID-19 pandemic, compulsory masks became an integral part of outdoor sports such as jogging in crowded areas (e.g. city parks) as well as indoor sports in gyms and sports centers. This study, therefore, aimed to investigate the effects of medical face masks on performance and cardiorespiratory parameters in athletes.

Methods
In a randomized, cross-over design, 16 well-trained athletes (age 27 ± 7 years, peak oxygen consumption 56.2 ± 5.6 ml kg−1 min−1, maximum performance 5.1 ± 0.5 Watt kg−1) underwent three stepwise incremental exercise tests to exhaustion without mask (NM), with surgical mask (SM) and FFP2 mask (FFP2). Cardiorespiratory and metabolic responses were monitored by spiroergometry and blood lactate (BLa) testing throughout the tests.

Results
There was a large effect of masks on performance with a significant reduction of maximum performance with SM (355 ± 41 Watt) and FFP2 (364 ± 43 Watt) compared to NM (377 ± 40 Watt), respectively (p < 0.001; ηp2 = 0.50). A large interaction effect with a reduction of both oxygen consumption (p < 0.001; ηp2 = 0.34) and minute ventilation (p < 0.001; ηp2 = 0.39) was observed. At the termination of the test with SM 11 of 16 subjects reported acute dyspnea from the suction of the wet and deformed mask. No difference in performance was observed at the individual anaerobic threshold (p = 0.90).

Conclusion
Both SM and to a lesser extent FFP2 were associated with reduced maximum performance, minute ventilation, and oxygen consumption. For strenuous anaerobic exercise, an FFP2 mask may be preferred over an SM.
Prospective study on the Eustachian tube function during Frenzel maneuver in a hypobaric/hyperbaric pressure chamber
Authors: Wolber Philipp , Meyer Moritz Friedo , Knesic Kristijana , Rink Svenja , Jansen Stefanie , Klussmann Jens Peter , Grosheva Maria 
Published: June 2021

Abstract
Introduction
The Frenzel maneuver describes a technique for middle ear equalizing which is frequently used by apnea divers. It offers advantages compared to the most commonly used techniques such as the Valsalva or Toynbee maneuver. Until now, there is insufficient literature about the pressure dynamics and Eustachian tube (ET) function during the Frenzel maneuver. The aim of the present study was to characterize the ET function during the Frenzel maneuver.

Materials and methods
By means of an established standardized profile of compression and decompression in a hypo/hyperbaric pressure chamber, we examined different parameters such as the ET opening pressure (ETOP), ET opening duration (ETOD), and ET opening frequency (ETOF) in 11 experienced apnea divers and compared them to the parameters during the Valsalva and Toynbee maneuver.

Results
Standard values for ETOP, ETOD, and ETOF could be established for the Frenzel maneuver under standardized conditions in a hypo/hyperbaric pressure chamber. Compared to the Frenzel maneuver, ETOP was higher and ETOD longer (both p < 0.001) during the Valsalva maneuver whereas ETOP was lower and ETOD shorter (both p < 0.001) during the Toynbee maneuver. No difference regarding ETOF was observed between the Frenzel, Valsalva, and Toynbee maneuver.

Discussion
The Frenzel maneuver was shown to be at least as effective as the Valsalva maneuver concerning ET opening. We believe that knowledge of the Frenzel technique might facilitate the pressure equalization during diving and recommend implementation of an appropriate equalization training in apnea and scuba diving education.
Frequent short sickness absence, occupational health service utilisation and long-term sickness absence due to mental disorders among young employees
Authors: Harkko Jaakko , Nordquist Hilla , Pietiläinen Olli , Piha Kustaa , Mänty Minna , Lallukka Tea , Rahkonen Ossi , Kouvonen Anne 
Published: June 2021

Abstract
Objectives
We examined whether frequent short-term sickness absence (FSTSA) and primary care use in occupational health service (OHS) were associated with medically-certified long-term sickness absence (LTSA) due to mental disorders among young employees.

Methods
We used record-linkage data covering the young employees (< 35 years) of the City of Helsinki, Finland (n = 8,282) from 2010 to 2014. The outcome was LTSA due to mental disorders. Cox regression models were fitted.

Results
FSTSAs were associated with subsequent LTSA. Also OHS use predicted LTSA due to mental disorders; however, this association was not found for those with prior FSTSA.

Conclusions
Both FSTSA and primary care use indicate subsequent LTSA independently, and together these indicators identify a larger proportion of individuals at risk of LTSA due to mental disorders.
Transmission of cell-associated human cytomegalovirus isolates between various cell types using polymorphonuclear leukocytes as a vehicle
Authors: Braun Berenike , Sinzger Christian 
Published: June 2021

AbstractPolymorphonuclear leukocytes (PMNs) are regarded as vehicles for the hematogenous dissemination of human cytomegalovirus (HCMV). In cell culture, this concept has been validated with cell-free laboratory strains but not yet with clinical HCMV isolates that grow strictly cell-associated. We, therefore, aimed to evaluate whether PMNs can also transmit such isolates from initially infected fibroblasts to other cell types, which might further clarify the role of PMNs in HCMV dissemination and provide a model to search for potential inhibitors. PMNs, which have been isolated from HCMV-seronegative individuals, were added for 3 h to fibroblasts infected with recent cell-associated HCMV isolates, then removed and transferred to various recipient cell cultures. The transfer efficiency in the recipient cultures was evaluated by immunofluorescence staining of viral immediate early antigens. Soluble derivatives of the cellular HCMV entry receptor PDGFRα were analyzed for their potential to interfere with this transfer. All of five tested HCMV isolates could be transferred to fibroblasts, endothelial and epithelial cells with transfer rates ranging from 2 to 9%, and the transferred viruses could spread focally in these recipient cells within 1 week. The PDGFRα-derived peptides IK40 and GT40 reduced transfer by 40 and 70% when added during the uptake step. However, when added during the transfer step, only IK40 was effective, inhibiting transmission by 20% on endothelial cells and 50–60% on epithelial cells and fibroblasts. These findings further corroborate the assumption of cell-associated HCMV dissemination by PMNs and demonstrate that it is possible to inhibit this transmission mode.
Effects of plant species diversity on nematode community composition and diversity in a long-term biodiversity experiment
Authors: Dietrich Peter , Cesarz Simone , Liu Tao , Roscher Christiane , Eisenhauer Nico 
Published: June 2021

AbstractDiversity loss has been shown to change the soil community; however, little is known about long-term consequences and underlying mechanisms. Here, we investigated how nematode communities are affected by plant species richness and whether this is driven by resource quantity or quality in 15-year-old plant communities of a long-term grassland biodiversity experiment. We extracted nematodes from 93 experimental plots differing in plant species richness, and measured above- and belowground plant biomass production and soil organic carbon concentrations (Corg) as proxies for resource quantity, as well as C/Nleaf ratio and specific root length (SRL) as proxies for resource quality. We found that nematode community composition and diversity significantly differed among plant species richness levels. This was mostly due to positive plant diversity effects on the abundance and genus richness of bacterial-feeding, omnivorous, and predatory nematodes, which benefited from higher shoot mass and soil Corg in species-rich plant communities, suggesting control via resource quantity. In contrast, plant-feeding nematodes were negatively influenced by shoot mass, probably due to higher top–down control by predators, and were positively related to SRL and C/Nleaf, indicating control via resource quality. The decrease of the grazing pressure ratio (plant feeders per root mass) with plant species richness indicated a higher accumulation of plant-feeding nematodes in species-poor plant communities. Our results, therefore, support the hypothesis that soil-borne pathogens accumulate in low-diversity communities over time, while soil mutualists (bacterial-feeding, omnivorous, predatory nematodes) increase in abundance and richness in high-diversity plant communities, which may contribute to the widely-observed positive plant diversity–productivity relationship.
Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy —short version of the updated German best practice guideline (S2e) — AWMF register no. 166-001, 6/2020
Authors: Ehren Rasmus , Benz Marcus R. , Brinkkötter Paul T. , Dötsch Jörg , Eberl Wolfgang R. , Gellermann Jutta , Hoyer Peter F. , Jordans Isabelle , Kamrath Clemens , Kemper Markus J. , Latta Kay , Müller Dominik , Oh Jun , Tönshoff Burkhard , Weber Stefanie , Weber Lutz T. ,   on behalf of the German Society for Pediatric Nephrology
Published: June 2021

AbstractIdiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. The following recommendations for the treatment of SSNS are based on the comprehensive consideration of published evidence by a working group of the German Society for Pediatric Nephrology (GPN) based on the systematic Cochrane reviews on SSNS and the guidelines of the KDIGO working group (Kidney Disease - Improving Global Outcomes).
Smart aging monitoring and early dementia recognition (SAMEDR): uncovering the hidden wellness parameter for preventive well-being monitoring to categorize cognitive impairment and dementia in community-dwelling elderly subjects through AI
Authors: Ghayvat Hemant , Gope Prosanta 
Published: June 2021

AbstractReasoning weakening because of dementia degrades the performance in activities of daily living (ADL). Present research work distinguishes care needs, dangers and monitors the effect of dementia on an individual. This research contrasts in ADL design execution between dementia-affected people and other healthy elderly with heterogeneous sensors. More than 300,000 sensors associated activation data were collected from the dementia patients and healthy controls with wellness sensors networks. Generated ADLs were envisioned and understood through the activity maps, diversity and other wellness parameters to categorize wellness healthy, and dementia affected the elderly. Diversity was significant between diseased and healthy subjects. Heterogeneous unobtrusive sensor data evaluate behavioral patterns associated with ADL, helpful to reveal the impact of cognitive degradation, to measure ADL variation throughout dementia. The primary focus of activity recognition in the current research is to transfer dementia subject occupied homes models to generalized age-matched healthy subject data models to utilize new services, label classified datasets and produce limited datasets due to less training. Current research proposes a novel Smart Aging Monitoring and Early Dementia Recognition system that provides the exchange of data models between dementia subject occupied homes (DSOH) to healthy subject occupied homes (HSOH) in a move to resolve the deficiency of training data. At that point, the key attributes are mapped onto each other utilizing a sensor data fusion that assures to retain the diversities between various HSOH & DSOH by diminishing the divergence between them. Moreover, additional tests have been conducted to quantify the excellence of the offered framework: primary, in contradiction of the precision of feature mapping techniques; next, computing the merit of categorizing data at DSOH; and, the last, the aptitude of the projected structure to function thriving due to noise data. The outcomes show encouraging pointers and highlight the boundaries of the projected approach.
Effect of the Rock Stress on the Water Jet Cutting Performance
Authors: Grosso Battista , Dentoni Valentina , Bortolussi Augusto 
Published: June 2021

AbstractUnderground quarrying is rarely adopted for granite extraction due to the difficulties in the implementation of traditional technologies (drilling and explosive). As alternative to drilling and explosive, the combination of diamond wire and water jet seems to be the most promising available technology. The cutting performance achievable with the water jet technology depends on the operative parameters, the material characteristics and the state of stress within the rock massif. To assess the effect of the state of stress on the cutting rate, laboratory tests have been performed with an oscillating water jet machine on granite samples subjected to a static load. The stress distribution in the layer of rock to be removed has been evaluated by numerical simulation with the FLAC code (Fast Lagrangian Analysis of Continua). The correlation between the results of the cutting tests and the numerical models of the rock samples has been inferred. Starting from a conceptual model, which theoretically describes the relationship between the cutting rate and the stress, a step function was defined that indicates the ranges of stress where predefined values of the cutting rate are workable.
A novel genomic classification system of gastric cancer via integrating multidimensional genomic characteristics
Authors: Wang Haiyong , Ding Yongfeng , Chen Yanyan , Jiang Junjie , Chen Yiran , Lu Jun , Kong Mei , Mo Fan , Huang Yingying , Zhao Wenyi , Fang Ping , Chen Xiangliu , Teng Xiaodong , Xu Nong , Lu Yimin , Yu Xiongfei , Li Zhongqi , Zhang Jing , Wang Haohao , Bao Xuanwen , Zhou Donghui , Chi Ying , Zhou Tianhua , Zhou Zhan , Chen Shuqing , Teng Lisong 
Published: June 2021

Abstract
Background
Gastric cancer (GC) is one of the leading causes of cancer deaths with high heterogeneity. There is currently a paucity of clinically applicable molecular classification system to guide precise medicine.

Methods
A total of 70 Chinese patients with GC were included in this study and whole-exome sequencing was performed. Unsupervised clustering was undertaken to identify genomic subgroups, based on mutational signature, copy number variation, neoantigen, clonality, and essential genomic alterations. Subgroups were characterized by clinicopathological factors, molecular features, and prognosis.

Results
We identified 32 significantly mutated genes (SMGs), including TP53, ARID1A, PIK3CA, CDH1, and RHOA. Of these, PREX2, PIEZO1, and FSIP2 have not been previously reported in GC. Using a novel genome-based classification method that integrated multidimensional genomic features, we categorized GC into four subtypes with distinct clinical phenotypes and prognosis. Subtype 1, which was predominantly Lauren intestinal type, harbored recurrent TP53 mutation and ERBB2 amplification, high tumor mutation burden (TMB)/tumor neoantigen burden (TNB), and intratumoral heterogeneity, with a liver metastasis tendency. Subtype 2 tended to occur at an elder age, accompanying with frequent TP53 and SYNE1 mutations, high TMB/TNB, and was associated with poor prognosis. Subtype 3 and subtype 4 included patients with mainly diffuse/mixed type tumors, high frequency of peritoneal metastasis, and genomical stability, whereas subtype 4 was associated with a favorable prognosis.

Conclusions
By integrating multidimensional genomic characteristics, we proposed a novel genomic classification system of GC associated with clinical phenotypes and provided a new insight to facilitate genome-guided risk stratification and disease management.
Comparison between 1973 and 2004/2016 World Health Organization grading in upper tract urothelial carcinoma treated with radical nephroureterectomy
Authors: Collà Ruvolo Claudia , Würnschimmel Christoph , Wenzel Mike , Nocera Luigi , Celentano Giuseppe , Mangiapia Francesco , Tian Zhe , Shariat Shahrokh F. , Saad Fred , Chun Felix H. C. , Briganti Alberto , Longo Nicola , Mirone Vincenzo , Karakiewicz Pierre I. 
Published: June 2021

Abstract
Aims
The European Association of Urology guideline for upper tract urothelial carcinoma (UTUC) relies on two grading system: 1973 World Health Organization (WHO) and 2004/2016 WHO. No consensus has been made which classification should supersede the other and both are recommended in clinical practice. We hypothesized that one may be superior to the other.

Methods
Newly diagnosed non-metastatic UTUC patients treated with radical nephroureterectomy were abstracted from the Surveillance, Epidemiology, and End Results database (2010–2016). Kaplan–Meier plots and multivariable Cox regression models (CRMs) tested cancer-specific mortality (CSM), according to 1973 WHO (G1 vs. G2 vs. G3) or to 2004/2016 WHO (low-grade vs. high-grade) grading systems. Haegerty’s C-index quantified accuracy.

Results
Of 4271 patients, according to 1973 WHO grading system, 134 (3.1%) were G1, 436 (10.2%) were G2 and 3701 (86.7%) were G3; while according to 2004/2016 WHO grading system, 508 (11.9%) were low grade vs 3763 (88.1%) high grade. In multivariable CRMs, high grade predicted higher CSM (Hazard ratio: 1.70, p < 0.001). Conversely, neither G2 (p = 0.8) nor G3 (p = 0.1) were independent predictors of worse survival. The multivariable models without consideration of either grading system were 74% accurate in predicting 5-year CSM. Accuracy increased to 76% after either addition of the 1973 WHO or 2004/2016 WHO grade.

Conclusions
From a statistical standpoint, either 1973 WHO or 2004/2016 WHO grading system improves the accuracy of CSM prediction to the same extent. In consequence, other considerations such as intra- and interobserver variability may represent additional metrics to consider in deciding which grading system is better.
Comparing the measurement properties of the ICECAP-A and ICECAP-O instruments in ages 50–70: a cross-sectional study on a representative sample of the Hungarian general population
Authors: Baji Petra , Farkas Miklós , Dobos Ágota , Zrubka Zsombor , Kovács Levente , Gulácsi László , Péntek Márta 
Published: June 2021

Abstract
Objective
The ICECAP-A and ICECAP-O were validated as capability wellbeing measures of adults aged 18 + and 65 + years, respectively. We aimed to compare their measurement properties in age group 50–70.

Methods
Data were derived from a cross-sectional survey among a sample representative for the adult Hungarian population. Respondents aged between 50 and 70 filled in both the ICECAP-A and ICECAP-O questionnaires. We assessed and compared feasibility, agreement, discriminatory power, convergent and content validity of the two instruments and explored the determinants of the differences between the two measures.

Results
707 respondents (99.4%) provided full answers to both questionnaires (46.3% women, average age 60.1 years). The instruments showed similar construct and convergent validity and discriminatory power. Pearson-correlations between instrument items were strong (r > 0.5). ICECAP-A and ICECAP-O scores could be calculated from each other with a good confidence (R2 = 0.69 and 0.71). ICECAP-O scores (mean 0.87, SD = 0.12) were systematically higher than ICECAP-A scores (0.85, SD = 0.15) in most subgroups. The difference increased with the deterioration of capability and health, and with age. Regression results showed that employment and health status had larger marginal effect on the ICECAP-A than on the ICECAP-O scores, and these effects were larger than the effect of age on both measures.

Conclusion
Validity of both instruments was confirmed in the age groups 50–70. Given that employment and health status are important determinants of the differences between the two instruments besides age, the possibility of linking the choice between ICECAP-A and ICECAP-O to these factors should be investigated by further research.
Applying NLP techniques to malware detection in a practical environment
Authors: Mimura Mamoru , Ito Ryo 
Published: June 2021

AbstractExecutable files still remain popular to compromise the endpoint computers. These executable files are often obfuscated to avoid anti-virus programs. To examine all suspicious files from the Internet, dynamic analysis requires too much time. Therefore, a fast filtering method is required. With the recent development of natural language processing (NLP) techniques, printable strings became more effective to detect malware. The combination of the printable strings and NLP techniques can be used as a filtering method. In this paper, we apply NLP techniques to malware detection. This paper reveals that printable strings with NLP techniques are effective for detecting malware in a practical environment. Our dataset consists of more than 500,000 samples obtained from multiple sources. Our experimental results demonstrate that our method is effective to not only subspecies of the existing malware, but also new malware. Our method is effective against packed malware and anti-debugging techniques.
The cost of risk management and multifunctionality in forestry: a simulation approach for a case study area in Southeast Germany
Authors: Friedrich Stefan , Hilmers Torben , Chreptun Claudia , Gosling Elizabeth , Jarisch Isabelle , Pretzsch Hans , Knoke Thomas 
Published: June 2021

AbstractForest management faces growing uncertainty concerning environmental conditions and demand for ecosystem services. To help forest managers consider uncertainty, we applied a robust and multi-criteria approach to select the optimal composition of a forest enterprise from 12 stand types. In our simulation, the forest enterprise strives for either financial return or a multi-criteria forest management considering financial return, carbon storage and forest ecosystem stability. To quantify the influence of climate change on these decision criteria, we used the concept of analogous climate zones. Our results provide recommendations for long-term strategies for tree species selection in a Southeast German forest enterprise. The results show that considering both uncertainty and multifunctionality in forest management led to more diversified forest compositions. However, robust and multi-criteria optimisation required the forest enterprise to pay a premium in terms of lower income. Financial returns decreased when forest composition accounted for uncertainty or multiple objectives. We also found that adaptation measures could only partly financially compensate the effects of climate change. As the study is limited to two tree species, including additional tree species, variants of mixing proportions and further silvicultural strategies in the optimisation appears a promising avenue for future research.