bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting ESL Students’ Critical Thinking Skills Through a Transitivity Analysis of Authentic Materials
Authors: Velasco Ender 
Published: October 2021

Using authentic materials in the English as a second language (ESL) classroom can develop students’ critical thinking (CT) skills, expose them to more realistic English, and support their motivation. Carrying out text analyses of authentic materials in the ESL classroom can also help students become more critical in their approach to reading. Grounded in systemic functional linguistics (SFL) concepts, this paper puts forward a series of text analysis tasks, so ESL teachers can introduce their adult students to the concepts of transitivity and intentionality found in opposing newspaper articles dealing with conflict. Overall, these analyses show how the active voice can highlight the semantic value of intentionality via material processes, and how writers use strategies such as passivization and fronting of items in clauses to emphasize the responsibility for wrongdoing when reporting news. The analyses also show that context is important in determining degrees of intentionality, and intentionality can be attributed to the material processes of human actors portrayed as non-human actors. Understanding these concepts can help adult ESL students become better critical readers/thinkers.
Utiliser des matériaux authentiques dans la classe d’anglais langue seconde (ALS) peut développer la pensée critique (PC) des étudiants et les exposer à un anglais plus réaliste et soutenir leur motivation. Effectuer des analyses de textes de matériaux authentiques dans la classe d’ALS peut aussi aider les étudiants à devenir plus critiques dans leur approche de la lecture. Enraciné dans les concepts de la linguistique systémique fonctionnelle (LSF), cet article présente une série d’exercices d’analyse de texte, de façon à ce que les enseignants d’ALS puissent présenter à leurs étudiants adultes les concepts de transitivité et d’intentionnalité qu’on retrouve dans des articles de presse contradictoires qui traitent du conflit. Dans l’ensemble, ces analyses montrent comment l’utilisation de la voix active peut mettre en lumière la valeur sémantique de l’intentionnalité par l’entremise de processus matériels, ainsi que la façon dont les écrivains utilisent des stratégies comme la passivisation et la mise en avant d’éléments dans les propositions pour accentuer la responsabilité d’actes répréhensibles quand ils font un reportage. Les analyses montrent également que le contexte est important pour déterminer les degrés d’intentionnalité et que celle-ci peut être attribuée aux processus matériels des acteurs humains dépeints comme des acteurs non-humains. Comprendre ces concepts aide les étudiants adultes d’ALS à devenir de meilleurs lecteurs ou penseurs critiques.
PLGA – THE SMART POLYMER FOR DRUG DELIVERY
Authors: Surya N. , Bhattacharyya S. 
Published: October 2021

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.
HEAT SHOCK PROTEIN HSP70: PREREQUISITES FOR USE AS A MEDICINAL PRODUCT
Authors: Pokrovsky V. M. , Patrakhanov E. A. , Antsiferov O. V. , Kolesnik I. M. , Belashova A. V. , Soldatova V. A. , Pokopeiko O. N. , Karagodina A. Yu. , Arkhipov I. A. , Voronina D. G. , Sushkova D. N. 
Published: October 2021

Heat shock protein Hsp70 is one of the main cytoprotection components under the action of various external stimuli. The analysis of the literature data shows that nowadays, the researches’ overwhelming evidence has proven the role of Hsp70 as a biological target for the drug development; however, the ideas about its use as a drug are often multidirectional.The aim of the article is to analyze and generalize the literature data on the features of the physiological functions of heat shock protein Hsp 70, and indicate the possibilities of its use for the pharmacological correction of various pathological conditions.Materials and methods. In the process of selecting material for writing this review article, such databases as Google Patents, Science Research Portal, Google Scholar, ScienceDirect, CiteSeer, Publications, ResearchIndex, Ingenta, PubMed, KEGG, etc. were used The following words and word combinations were selected as markers for identifying the literature: Hsp70, Hsp70 stroke, Hsp70 neuroprotection, Hsp70 cytoprotection, recombinant drugs.Results. In this review, the pharmacology of one of the key members of this family, Hsp70, was focused on. The literary analysis confirms that this molecule is an endogenous regulator of many physiological processes and demonstrates tissue protective effects in modeling ischemic, neurodegenerative and inflammatory processes. The use of recombinant exogenous Hsp70 mimics the endogenous function of the protein, indicating the absence of a number of typical limitations characteristic of pharmacotherapy with high molecular weight compounds, such as immunogenicity, a rapid degradation by proteases, or a low penetration of histohematogenous barriers.Conclusion. Thus, Hsp70 may become a promising agent for clinical trials as a drug for the treatment of patients with neurological, immunological, and cardiovascular profiles.
TYPE 2 DIABETES MELLITUS’S DECOMPENSATED FORM: ON THE PROBLEM OF EFFECTIVE PHARMACOTHERAPY IN REAL CLINICAL PRACTICE
Authors: Safronenko A. V. , Gantsgorn E. V. , Sanina E. A. , Khachumova M. A. , Panenko S. O. , Kuznetsov I. I. , Kivva A. A. , Polyakova V. I. 
Published: October 2021

The aim of this retrospective study was to analyze the pharmacotherapy regimens of the decompensated form of type 2 diabetes mellitus (DM2) and to evaluate its effectiveness, its compliance with clinical recommendations.Materials and methods: A retrospective analysis of 54 medical cards of patients with decompensated DM2 was conducted. The 1st group (n=24; 44%) included the patients who had a decrease in glycated hemoglobin (HbA1c) by 50% or more in 3 months after hypoglycemic therapy; and the 2nd group (n=30; 56%) – the patients whose HbA1c level decreased by less than 50%.Results. A HbA1c level was 10.4% in the 1st group and 13.2% in the 2nd group (р<0.001). However, the target levels of venous blood plasma glucose and HbA1c were not achieved in any of the patient groups. The total number of the drugs prescribed to the patients ranged from 4 (in 25% (n=6) and 10% (n=3) cases in the 1st and the 2nd groups, respectively) to 8 (in 12.5% (n=3) and 20% (n=6) cases in the 1st and the 2nd, groups, respectively). However, in a number of cases some violations of clinical recommendations were recorded: the prescription to the obese patients of insulin drugs, the administration of sulfonylureas derivatives to patients with a history of cardiovascular diseases of the atherosclerotic origin, but modern hypoglycemic drugs with proven benefits in reducing cardiovascular risks were rarely prescribed.Conclusion. The tactics of pharmacotherapy in the patients with a decompensated form of DM2 does not fully comply with the approved clinical guidelines, which requires the effectiveness of treatment optimization of this medically and socially significant pathology.
COST-MINIMIZATION ANALYSIS OF USING SHORT AND LONG-ACTING ERYTHROPOESIS-STIMULATING AGENTS FOR CORRECTION OF NEPHROGENIC ANEMIA AGAINST THE BACKGROUND OF SUBSTITUTION THERAPY
Authors: Krysanov I. S. , Ermakova E. Yu. , Vaskova L. B. , Tiapkina M. V. 
Published: October 2021

Clinical trials conducted in various countries indicate that the use of epoetin alfa in patients with nephrogenic anemia in chronic kidney disease can increase the effectiveness of treatment, reduce the incidence of cardiovascular and infectious complications, and reduce mortality in patients with chronic kidney disease.The aim of the article was to conduct a comparative clinical and economic assessment of the treatment costs of nephrogenic anemia in adult dialysis patients with recombinant human erythropoietins: epoetin alfa, darbepoetin and long-acting methoxy polyethylene glycol – epoetin beta.Materials and methods. The study took into account direct medical costs of nephrogenic anemia pharmacotherapy on the basis of 1 year maintenance therapy according to the following scheme: epoetin alfa – 3 times per week, darbepoetin alfa – once per week, methoxy polyethylene glycol – epoetin beta – once per 2 or 4 weeks. A “costs minimization” analysis was performed for equivalent maintenance epoetins doses for intravenous and subcutaneous administrations. Epoetin alpha equivalents were calculated for an average patient weighing 75 kg by converting a weekly dose of short-acting epoetin (7500 IU) into equivalent doses using dose conversion factors.Results. In the hypothetical cohort of patients under study, epoetin alfa, darbepoetin alfa, and methoxy polyethylene glycol – epoetin beta not differ in effectiveness in achieving target Hb values and in safety. With the equal effectiveness of the investigated drugs, in the studied patients, intravenous epoetin alfa can be less expensive drug therapy relative to the equivalent doses obtained by the calculation: darbepoetin by 14–24% and methoxy polyethylene glycol – epoetin beta by 4–30%. The change-over of patients to the subcutaneous administration makes it possible to decline a weekly dose of epoetin alfa by 20–30% by reducing the frequency of taking the drug to twice a week, and to reduce the cost of drug therapy by a third.Conclusion. Intravenous and subcutaneous administrations of epoetin alfa 2500 IU may be a more economical drug therapy in comparison with the equivalent doses of darbepoetin and methoxy polyethylene glycol – epoetin beta.
ANTIHISTAMINES: RESEARCH AND ANALYSIS OF THE REGIONAL RETAIL MARKET
Authors: Prokopenko V. V. , Kabakova T. I. , Chernikov M. V. , Goryachev A. B. , Mikhailova S. A. , Knysh O. I. 
Published: October 2021

the aim. Focused on optimizing the assortment portfolio of pharmacy organizations and improving the process of drug supply to end-consumers, the aim of the study was to analyze the regional pharmaceutical market for antihistamines.Materials and methods. In the study, the following methods were used: a content analysis of regulatory documents; a documentary observation method of the volume of antihistamines sales; a sociological survey method. The objects of the study were accounting registers in 32 pharmacy organizations for 2020, as well as the sociological survey results of 174 respondents – consumers of antihistamines.Results. The classification analysis of 38 international non-proprietary trade names of antihistamines, represented by 187 names of drugs, revealed the prevalence of the first-generation drugs (63%). On the Russian pharmaceutical market, there were also 55% of foreign production drugs. At the regional level, there are 66 types of drugs in circulation, 50% of which are second-generation ones. The cost analysis showed rather a wide rage of the pricing proposal and the economic availability of antihistamines for patients. The sociological survey revealed the fact that 46% of the consumers were ready to pay for the necessary drugs in the price range “over 100 and up to 500 rubles” (over $ 1.38 and up to $ 6.88) for one conventional package. A medical-demographic profile of the antihistamines consumer at the regional level has been made up, and guidelines for pharmaceutical specialists on managing the assortment portfolio of pharmaceutical organizations have been developed.Conclusion. As a result of the study, the following facts have been established: the seasonal peaks in the antihistamines consumption; a gradual renewal of the pharmacies assortment portfolio due to the increased consumption of the second and third generation antihistamines. The medical and demographic profile of the consumer should be taken into consideration when planning a drug provision for the patients with allergic pathologies, and it is connected with the growth in pharmacies profits due to the sale of drugs in the range from 100 to 500 rubles (from $ 1.38 to $ 6.88). The methodical recommendations have been brought to the attention of the management of regional pharmacy organizations.
ACTUAL PROBLEMS OF PROFESSIONAL AND PERSONAL DEVELOPMENT QUALIFIED PERSONS RESPONSIBLE FOR QUALITY OF MEDICINAL PRODUCTS FOR HUMAN USE
Authors: Aladysheva Zh. I. , Pyatigorskaya N. V. , Belyaev V. V. , Nikolenko N. S. , Nesterkina E. I. , Loseva S. A. 
Published: October 2021

The aim of the study is to investigate topical problems of the professional and personal development of qualified persons responsible for quality of medicinal products for human use.Materials and methods. In the period from April 6 to May 10, 2020, an online survey of leading employees in the field of quality assurance of Russian manufacturers was conducted. 176 people took part in the survey; the return of questionnaires was about 17.9%.Results. From the standpoint of D. Super’s theory of professional development, the largest number of respondents was at the maintenance stage, holding their achieved positions (53.2%). All respondents, regardless of age, were motivated for professional development. Most often qualified persons had chemical engineering (27.3%) and pharmaceutical education (22.2%). Most of them had a working experience in 1–2 divisions of the enterprise, and combined the functions of qualified persons with managerial positions (74.5% and 71.9%, respectively). The majority of the qualified persons (86.4%) indicated the sufficiency of the available knowledge and the lack of knowledge on certain issues. Knowledge and skills in the quality risk management, specific GMP issues and statistical methods (59.0%, 49.2 and 44.2%, respectively); communication and interpersonal skills and, in particular, stress management, emotion management and the art of negotiation (49.4%, 41.3% and 40.9%, respectively), were most popular. About 36% of respondents notified the need for the digital economy competencies, while only 5.1% notified the presence of an electronic batch production record at the enterprise. Finally, only half of the respondents (50.5%) had a formal training plan for qualified persons.Conclusion. This pilot study revealed the need for the revision of the Exemplary Additional Professional Training Program for Qualified Persons and the professional standard, the urgent need for the regulatory body to develop a scheme and principles for the continuous professional development of qualified persons, and showed the direction of further research in this area.
Influence of Temperature on Quantification of Mesocracks: Implications for Physical Properties of Fine-Grained Granite
Authors: Chun Zhu , Yun Lin , Gan Feng 
Published: October 2021

Abstract
Thermally induced changes in mesocrack and the physical properties of fine-grained granite may influence their stability, transport characteristics, and performance related to various deep subsurface energy projects. In this study, granite was heat-treated at different temperatures (20°C, 100°C, 200°C, 300°C, 400°C, 500°C, and 600°C). The propagation and evolution of different types of cracks and the physical properties of the granite were quantitatively investigated, using optical observations of petrographic thin sections, P-wave velocity measurements, and permeability tests. The results show that as the temperature increased, the number and length of cracks increased, and the cracks were randomly distributed in all directions. This led to an increase in rock damage (λn) and an increase in permeability (K). In particular, when the temperature was ≥400°C, the damage rate significantly increased, and the number and length of intragranular cracks significantly exceeded the number and length of intergranular cracks. This led to changes in the permeation path, causing it to mainly travel through the interior of mineral particles. Using the inverse of P-wave velocity (VP), the dimensionless crack density (ρ) of granite was found to increase as the temperature increased, and this result was similar to the change of optical crack density (Pl). These analyses laid a reference for understanding the correlation between microcrack characteristics and macrophysical properties of granite.
Reservoir Simulation of CO2 Sequestration in Shale Reservoir
Authors: He Qin , Reid Teresa , Zheng Guofang 
Published: October 2021

Abstract
Increased production in natural gas from shale reservoirs has sparked concern that greenhouse gas emissions have also been on the rise. As a result, large- and small-scale operators and service companies are enthusiastically supporting a push toward "net carbon zero emissions". Carbon capture utilization and storage (CCUS) is playing an impactful role in companies’ goals to reach net zero. CO2 sequestration is the process of capturing and storing CO2 emissions from industrial and energy-related sources. Most CO2 sequestration are recommended to locate in saline aquifer, coalbed zone and depleted reservoirs, while CO2 sequestration in shale reservoir could become another good option to minimize the environmental footprint and enhance the gas production. Similar as CO2 sequestration into coalbed methane reservoir, the fluid flow mechanism in shale also includes desorption, diffusion and Darcy's law.
In this paper, the effects of CO2 sequestration on shale reservoirs will be discussed from a technical and economical viewpoint. A reservoir simulation was used to evaluate the quantity of CO2 that can be stored in shale, the effects of CO2 mitigation when injected into shale, and any significant opportunities for CO2 enhanced shale gas recovery. Lastly, an economic analysis was performed to evaluate the economic efficiency of such projects in shales.
Application Investigation of Light Proppant in Hydraulic Fracturing of Marcellus Shale
Authors: Alhemdi Aymen , Gu Ming 
Published: October 2021

Abstract
Slickwater-sand fracturing design is widely employed in Marcellus shale. The slickwater- sand creates long skinny fractures and maximizes the stimulated reservoir volume (SRV). However, due to the fast settling of sand in the water, lots of upper and deeper areas are not sufficiently propped. Reducing sand size can lead to insufficient fracture conductivity. This study proposes to use three candidate ultra-lightweight proppants ULWPs to enhance the fractured well performance in unconventional reservoirs.
In step 1, the current sand pumping design is input into an in-house P3D fracture propagation simulator to estimate the fracture geometry and proppant concentrations. Next, the distribution of proppant concentration converts to conductivity and then to fracture permeability. In the third step, the fracture permeability from the second step is input into a reservoir simulator to predict the cumulative production for history matching and calibration. In step 4, the three ULWPs are used to replace the sand in the frac simulator to get new frac geometry and conductivity distribution and then import them in reservoir model for production evaluation. Before this study, the three ULWPs have already been tested in the lab to obtain their long-term conductivities under in-situ stress conditions. The conductivity distribution and production performance are analyzed and investigated.
The induced fracture size and location of the produced layer for the current target well play a fundamental effect on ultra-light proppant productivity. The average conductivity of ULWPs with mesh 40/70 is larger and symmetric along the fracture except for a few places. However, ULWPs with mesh 100 generates low average conductivity and create a peak conductivity in limited areas. The ULW-3 tends to have less cumulative production compared with the other ULWPs. For this Marcellus Shale study, the advantages of ultra-lightweight proppant are restricted and reduced because the upward fracture height growth is enormous. And with the presence of the hydrocarbon layer is at the bottom of the fracture, making a large proportion of ULWPs occupies areas that are not productive places.
The current study provides a guidance for operators in Marcellus Shale to determine (1) If the ULWP can benefit the current shale well treated by sand, (2) what type of ULWP should be used, and (3) given a certain type of ULWP, what is the optimum pumping schedule and staging/perforating design to maximize the well productivity. The similar workflow can be expanded to evaluate the economic potential of different ULWPs in any other unconventional field.
Application of Artificial Intelligence To Predict Time-Dependent Mud-Weight Windows in Real Time
Authors: Phan Dung T. , Liu Chao , AlTammar Murtadha J. , Han Yanhui , Abousleiman Younane N. 
Published: October 2021

Summary
Selection of a safe mud weight is crucial in drilling operations to reduce costly wellbore-instability problems. Advanced physics models and their analytical solutions for mud-weight-window computation are available but still demanding in terms of central-processing-unit (CPU) time. This paper presents an artificial-intelligence (AI) solution for predicting time-dependent safe mud-weight windows and very refined polar charts in real time. The AI agents are trained and tested on data generated from a time-dependent coupled analytical solution (poroelastic) because numerical solutions are prohibitively slow. Different AI techniques, including linear regression, decision tree, random forest, extra trees, adaptive neuro fuzzy inference system (ANFIS), and neural networks are evaluated to select the most suitable one. The results show that neural networks have the best performances and are capable of predicting time-dependent mud-weight windows and polar charts as accurately as the analytical solution, with 1/1,000 of the computer time needed, making them very applicable to real-time drilling operations. The trained neural networks achieve a mean squared error (MSE) of 0.0352 and a coefficient of determination (R2) of 0.9984 for collapse mud weights, and an MSE of 0.0072 and an R2 of 0.9998 for fracturing mud weights on test data sets. The neural networks are statistically guaranteed to predict mud weights that are within 5% and 10% of the analytical solutions with probability up to 0.986 and 0.997, respectively, for collapse mud weights, and up to 0.9992 and 0.9998, respectively, for fracturing mud weights. Their time performances are significantly faster and less demanding in computing capacity than the analytical solution, consistently showing three-orders-of-magnitude speedups in computational speed tests. The AI solution is integrated into a deployed wellbore-stability analyzer, which is used to demonstrate the AI’s performances and advantages through three case studies.