bluuebunny/crossref_metadata_2025_split huggingface dataset:
A possible shortcut for neutron–antineutron oscillation through mirror world
Authors: Berezhiani Zurab 
Published: January 2021

AbstractExisting bounds on the neutron-antineutron mass mixing, $$\epsilon _{n{\bar{n}}} < \mathrm{few} \times 10^{-24}$$

ϵ

n

n

¯

<
few
×

10

-
24

eV, impose a severe upper limit on $$n - {\bar{n}}$$

n
-

n

¯

transition probability, $$P_{n{\bar{n}}}(t) < (t/0.1 ~\mathrm{s})^2 \times 10^{-18}$$

P

n

n

¯

(
t
)

<

(
t
/
0.1

s
)

2

×

10

-
18

or so, where t is the neutron flight time. Here we propose a new mechanism of $$n- {\bar{n}}$$

n
-

n

¯

transition which is not induced by direct mass mixing $$\epsilon _{n{\bar{n}}}$$

ϵ

n

n

¯

but is mediated instead by the neutron mass mixings with the hypothetical states of mirror neutron $$n'$$

n
′

and mirror antineutron $${{\overline{n}}} '$$

n
¯

′

. The latter can be as large as $$\epsilon _{nn'}, \epsilon _{n\bar{n}'} \sim 10^{-15}$$

ϵ

n

n
′

,

ϵ

n

n

¯

′

∼

10

-
15

eV or so, without contradicting present experimental limits and nuclear stability bounds. The probabilities of $$n-n'$$

n
-

n
′

and $$n-\bar{n}'$$

n
-

n

¯

′

transitions, $$P_{nn'}$$

P

n

n
′

and $$P_{n\bar{n}'}$$

P

n

n

¯

′

, depend on environmental conditions in mirror sector, and they can be resonantly amplified by applying the magnetic field of the proper value. This opens up a possibility of $$n-{\bar{n}}$$

n
-

n

¯

transition with the probability $$P_{n{\bar{n}}} \simeq P_{nn'} P_{n\bar{n}'}$$

P

n

n

¯

≃

P

n

n
′

P

n

n

¯

′

which can reach the values $$\sim 10^{-8} $$

∼

10

-
8

or even larger. For finding this effect in real experiments, the magnetic field should not be suppressed but properly varied. These mixings can be induced by new physics at the scale of few TeV which may also originate a new low scale co-baryogenesis mechanism between ordinary and mirror sectors.
Proceedings of the second MadAnalysis 5 workshop on LHC recasting in Korea
Authors: Araz Jack Y. , Conte Eric , Ducrocq Robin , Flacke Thomas , Fuks Benjamin , Jeon Si Hyun , Kim Taejeong , Ko Pyungwon , Lee Seung J. , Ruiz Richard , Sengupta Dipan 
Published: January 2021

We document the activities performed during the second MadAnalysis 5 workshop on LHC recasting, that was organised in KIAS (Seoul, Korea) on February 12-20, 2020. We detail the implementation of 12 new ATLAS and CMS searches in the MadAnalysis 5 Public Analysis Database, and the associated validation procedures. Those searches probe the production of extra gauge and scalar/pseudoscalar bosons, supersymmetry, seesaw models and deviations from the Standard Model in four-top production.
Implementation of the CMS-EXO-17-030 analysis in the MadAnalysis 5 framework (production of a pair of resonances decaying each into three jets; 35.9 fb−1)
Authors: Kang Yechan , Kim Jihun , Choi Jin , Yun Soohyun 
Published: January 2021

We present the MadAnalysis 5 implementation and validation of the CMS-EXO-17-030 search. The search targets pair-produced resonances, each of which decaying into three jets. The results are interpreted within an [Formula: see text]-parity violating supersymmetric (RPV SUSY) model, that predicts that pair-produced gluinos decay into three jets. This leads to a six-jet event. For this study, proton–proton collision data which was collected with the CMS detector in 2016 at a center of energy of 13 TeV is used, with a corresponding luminosity of 35.9 fb[Formula: see text]. In the search, the resonance mass is expected to range from 200 GeV to 2000 GeV so that the analysis comprises four signal regions (SRs). To validate the results, we have selected four gluino benchmark masses of 200, 500, 900, and 1600 GeV, each of which being representative of a given signal region (that are denoted SR1, SR2, SR3, and SR4). We have simulated signal events and calculated the signal acceptance within the MadAnalysis 5 framework in each signal region. To validate the recast, our predicted acceptances have been compared with the official values for those benchmark scenarios. An agreement at the level of about 10% has been obtained.
Methyl Gallate Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Suppressing Oxidative Stress
Authors: Ahmed Akheruz Zaman , Satyam Shakta Mani , Shetty Prakashchandra , D’Souza Melanie Rose 
Published: January 2021

Doxorubicin-induced cardiotoxicity is the leading cause of morbidity and mortality among cancer survivors. The present study was aimed to investigate the cardioprotective potential of methyl gallate; an active polyphenolic nutraceutical, against doxorubicin-induced cardiotoxicity in Wistar rats. Twenty-four female Wistar rats (150–200 g) were divided into four groups (n = 6) which consist of normal control (group I), doxorubicin control (group II), test-A (group III), and test-B (group IV). Group III and group IV animals were prophylactically treated with methyl gallate 150 mg/kg/day and 300 mg/kg/day orally, respectively, for seven days. Doxorubicin (25 mg/kg; single dose) was administered through an intraperitoneal route to group II, III, and IV animals on the seventh day to induce acute cardiotoxicity. On the 8th day, besides ECG analysis, serum CK, CK-MB, LDH, AST, MDA, and GSH were assayed. Following gross examination of isolated hearts, histopathological evaluation was performed by light microscopy. A significant (

p

< 0.05) cardiac injury, as well as oxidative stress, was observed in doxorubicin control rats in comparison to normal control rats. Methyl gallate at both the doses significantly (

p

< 0.05) reduced doxorubicin-induced ECG changes, dyslipidaemia, and elevation of CK, CK-MB, LDH, AST, MDA and increased GSH level. Methyl gallate reversed the doxorubicin-induced histopathological changes in the heart. The present study revealed that methyl gallate exerts cardioprotection against doxorubicin-induced cardiotoxicity in female Wistar rats by suppressing oxidative stress. Our study opens the perspective to clinical studies for consideration of methyl gallate as a potential chemoprotectant nutraceutical in the combination chemotherapy with doxorubicin to limit its cardiotoxicity.
Prognostic Impacts of Comorbid Significant Coronary Stenosis and Coronary Artery Spasm in Patients With Stable Coronary Artery Disease
Authors: Hao Kiyotaka , Takahashi Jun , Kikuchi Yoku , Suda Akira , Sato Koichi , Sugisawa Jun , Tsuchiya Satoshi , Shindo Tomohiko , Nishimiya Kensuke , Ikeda Shohei , Tsuburaya Ryuji , Shiroto Takashi , Matsumoto Yasuharu , Miyata Satoshi , Sakata Yasuhiko , Yasuda Satoshi , Shimokawa Hiroaki 
Published: January 2021

BACKGROUND
Stable coronary artery disease is caused by a variable combination of organic coronary stenosis and functional coronary abnormalities, such as coronary artery spasm. Thus, we examined the clinical importance of comorbid significant coronary stenosis and coronary spasm.

METHODS AND RESULTS

We enrolled 236 consecutive patients with suspected angina who underwent acetylcholine provocation testing for coronary spasm and fractional flow reserve (FFR) measurement. Among them, 175 patients were diagnosed as having vasospastic angina (VSA), whereas the remaining 61 had no VSA (non‐VSA group). The patients with VSA were further divided into the following 3 groups based on angiography and FFR: no organic stenosis (≤50% luminal stenosis; VSA‐alone group, n=110), insignificant stenosis of FFR>0.80 (high‐FFR group, n=36), and significant stenosis of FFR≤0.80 (low‐FFR group, n=29). The incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, urgent percutaneous coronary intervention, and hospitalization attributed to unstable angina was evaluated. All patients with VSA received calcium channel blockers, and 28 patients (95%) in the low‐FFR group underwent a planned percutaneous coronary intervention. During a median follow‐up period of 656 days, although the incidence of major adverse cardiovascular events was low and comparable among non‐VSA, VSA‐alone, and high‐FFR groups, the low‐FFR group had an extremely poor prognosis (non‐VSA group, 1.6%; VSA‐alone group, 3.6%; high‐FFR group, 5.6%; low‐FFR group, 27.6%) (
P
<0.001). Importantly, all 8 patients with major adverse cardiovascular events in the low‐FFR group were appropriately treated with percutaneous coronary intervention and calcium channel blockers.

CONCLUSIONS
These results indicate that patients with VSA with significant coronary stenosis represent a high‐risk population despite current guideline‐recommended therapies, suggesting the importance of routine coronary functional testing in this population.
Web-Conference Lecturing: In Dialogue with Student Experiences During a Pandemic
Authors: Westbrook Fiona , Tibb Anna , Blackall Leigh , Zabde Hepsibah 
Published: January 2021

Abstract

covid-19 is an omnipresent feature of 2020, both globally and within Australia. For university students, a consequence of this has been the shift from on-campus to online delivery. Exploring these visual realities for lecturers and students, this article engages in Bakhtinian dialogism; a dialogic interaction that is born between peoples searching for meaning (Bakhtin, 1986). To do so, the authors engaged with and responded to students’ survey data whom they lecture and coordinate. Although the survey had limited responses, it enabled the authors to dialogue about received knowledge (istina) from students and contemplate this in relation to the authors’ own perspectives and experiences (pravda). Through this engagement, they suggest the importance of visually imbued emotive connectivity and dialogic relational care within web-conferencing, as well as didactic lecturing as valid forms of visual engagement.
A Virtual Choir Ecology and the Zoom-machinic
Authors: Grushka Kathryn , Lawry Miranda , Sutherland Kim , Fergusson Charissa 
Published: January 2021

Abstract

covid-19 has changed the way we sing in choirs and has seen the extraordinary uptake of Zoom as a video chat platform across society. This is a reflective tale of four choirs members and their insights into how they improvised with traditional choir singing in a Zoom space. It consideres how zoom pedagogies allowed them to bridge social isolation during the pandemic. It includes the voices of the conductor; music teacher/technician; the voice of a media savvy artist choir member and finally the voice of a singing visual educator. The article embeds Deleuzoguattarian thinking. It draws on the concepts of the machinic assemblage and becoming as choir participants who embraced Zoom to facilitate song. Singing in a zoom virtual choir brings forth a burgeoning new relational way of being. To find ways to sing and imagine life and self without physical, temporal and spatial borders.
Helping Children with Special Needs: Who Receives Tympanostomy Tubes?
Authors: Wassef David W. , Dhaduk Nehal , Roy Savannah C. , Barinsky Gregory L. , Kalyoussef Evelyne 
Published: January 2021

Objectives: Tympanostomy tubes can prevent sequelae of otitis media that adversely affect long term hearing and language development in children. These negative outcomes compound the existing difficulties faced by children who are already diagnosed with developmental disorders. This study aims to characterize this subset of children with developmental disorders undergoing myringotomy and tympanostomy tube insertion. Methods: A retrospective review using the Kids’ Inpatient Database (KID) was conducted, with codes from International Classification of Diseases, Ninth Revision used to query data from the years 2003 to 2012 to determine a study group of children with a diagnosis of a developmental disorder undergoing myringotomy and tympanostomy insertion. This group was compared statistically to patients undergoing these procedures who did not have a diagnosed developmental disorder. Results: In total, 21 945 cases of patients with myringotomy with or without tympanostomy tube insertion were identified, of which 1200 (5.5%) had a diagnosis of a developmental disorder. Children with developmental disorders had a higher mean age (3.3 years vs 2.9 years, P = .002) and higher mean hospital charges ($43 704.77 vs $32 764.22, P = .003). This cohort also had higher proportions of black (17.6% vs 12.3%, P < .001) and Hispanic (23.9% vs 20.6%, P = .014) patients, and had lower rates of private insurance coverage (39.6% vs 49%, P < .001). Conclusion: The population of children with developmental disorders undergoing myringotomy or tympanostomy tube placement has a different demographic composition than the general population and faces distinct financial and insurance coverage burdens. Further study should be done to assess if these differences impact long term outcomes.
The Effect of Lateral Pharyngeal Collapse Patterns on Therapy Response in Upper Airway Stimulation Surgery
Authors: Flynn John , Boyd Christopher , Yalamanchali Sreeya , Rouse David , Goodwin Sara , Penn Joseph , Larsen Christopher 
Published: January 2021

Objectives: Obstructive sleep apnea (OSA) is characterized by repeated upper airway collapse while sleeping which leads to intermittent hypoxemia. Upper airway stimulation (UAS) is a commonly practiced modality for treating OSA in patients who cannot tolerate, or do not benefit from, positive airway pressure (PAP). The purpose of this study is to identify the effect of lateral pharyngeal collapse patterns on therapy response in UAS. Methods: A retrospective cohort study from a single, tertiary-care academic center was performed. Patients who underwent UAS between October 2016 and July 2019 were identified and analyzed. Drug-induced Sleep Endoscopy (DISE) outcomes between Apnea-Hypopnea Index (AHI) responders and AHI non-responders were compared. Those with complete concentric collapse at the velopharynx were not candidates for UAS. Results: About 95 patients that underwent UAS were included in this study. Pre- to Post-UAS demonstrated significant improvements in Epworth Sleepiness Scale (12.0 vs 4.0, P = .001), AHI (29.8 vs 5.4, P < .001) and minimum oxygen saturation (79% vs 83%, P < .001). No DISE findings significantly predicted AHI response after UAS. Specifically, multiple types of lateral pharyngeal collapse patterns did not adversely effect change in AHI or AHI response rate. Conclusion: Demonstration of lateral pharyngeal collapse on DISE, in the absence of complete concentric velopharyngeal obstruction, does not appear to adversely affect AHI outcomes in UAS patients. Level of Evidence VI
The association of psychiatric and neurological comorbidities with outcomes in traumatic injury patients
Authors: Brady Jennifer , Hayward R David , Edhayan Elango 
Published: January 2021

Introduction Mental illness is a well-known risk factor for injury and injury recidivism. The impact of pre-existing psychiatric illness on trauma outcomes, however, has received less attention. Our study examines the relationship of pre-existing psychiatric illness on trauma outcomes including length of stay, cost, and mortality. Methods Patient data were obtained from the Healthcare Cost and Utilization Project’s State Inpatient Database. All patients admitted for trauma in the Detroit metropolitan area from 1/1/2006 to 12/31/2014 were included. The relationship between individual psychiatric comorbidities (depression, psychosis, and other neurological disorders) and outcomes were evaluated with logistic regression (mortality) and generalized linear modeling (length of stay and cost). Results Over 260,000 records were reviewed. Approximately one-third (29.9%) of patients had one or more psychiatric diagnoses. Patients with depression had longer hospital stays (RR = 1.12, p < 0.001) and higher costs (RR = 1.07, p < 0.001), but also lower mortality (OR = 0.69, p < 0.001). Patients with psychosis had longer stays (RR = 1.18, p < 0.001), higher costs (RR = 1.02, p = 0.002), and lower mortality (OR = 0.61, p < 0.001). Patients with other neurological comorbidities had higher mortality (OR = 1.23, p < 0.001), longer stays (RR = 1.29, p < 0.001), and higher costs (RR = 1.10, p < 0.001). Conclusion Patients with a psychiatric disorder required longer care and incurred greater costs, whereas mortality was higher for only those with a neurological disorder. Identifying patients’ psychiatric comorbidities at the time of admission for trauma may help optimize treatment. Addressing these conditions may help reduce the cost of trauma care.
The Effects of Offering Proactive Student-Success Coaching on Community College Students’ Academic Performance and Persistence
Authors: Hall Mark M. , Worsham Rachel E. , Reavis Grey 
Published: January 2021

Objective: This study examined the effects of offering proactive student-success coaching, informed by predictive analytics, on student academic performance and persistence. Specifically, this study investigated semester grade point average (GPA) and semester-to-semester persistence of community college students as outcomes. Methods: This study involved two stages of analysis. First, we used inverse probability of treatment weighting to create appropriately balanced samples of the students offered proactive assistance and students not offered proactive assistance to approximate a randomized control trial with observational data. Then, we applied regression analyses with weights and covariates to the balanced samples to estimate outcomes. Results: Using regression analyses with weights and covariates, we estimated few statistically significant results in sample subgroup models and no statistically significant results for whole-group samples. Generally, our analyses found that the offer of the intervention had no effect on students’ persistence and semester GPAs. Conclusions/Contributions: This study contributes empirical results to the emerging literature regarding student-success coaching, predictive analytics, and student-monitoring systems. The results demonstrate the necessity of performing rigorous analyses on these predictive-analytic systems and reveals ethical concerns that should be considered in designing interventions.
Differences in the Selection of Health State Utility Values by Sponsorship in Published Cost-Effectiveness Analyses
Authors: Hendrix Nathaniel , Kim David D. , Patel Krishna S. , Devine Beth 
Published: January 2021

Background Health state utility values (HSUVs) are among the most influential attributes of cost-effectiveness analyses (CEAs). Our objective was to evaluate whether industry-funded studies select systematically different HSUVs as compared with studies without industry funding. Methods Among 10 diseases with high disease burden in the United States, we further identified 31 progressive health states. We then searched the Tufts Medical Center’s CEA Registry to identify studies that included HSUVs and were submitted to the registry between 2002 and 2019. Two reviewers mapped the free-text descriptions of health states onto the 31 predefined health states. We analyzed the effect of industry funding on the point estimates of these HSUVs with a beta regression. We also analyzed the difference between related health states within studies by funding source with a linear regression. Results After identifying 26,222 HSUVs from 4198 CEAs, we matched 2573 HSUVs to the 31 predefined health states. We observed large variations within each health state: 12 of 31 health states included a range of HSUVs greater than 0.5. The point estimate model showed 1 statistically significant difference of 31 comparisons between studies with any industry funding and those without. The utility difference model found 3 significant differences out of 39 comparisons between CEAs with any industry funding and those without. Limitations Inclusion of unpublished CEAs may have affected our conclusions about the effect of industry funding on selection of HSUVs. We also relied on free-text descriptions of health states available in the CEA Registry and did not include adjustment for multiple comparisons. Conclusion Limited evidence exists that industry-funded studies select different HSUVs compared to non-industry-funded studies for the health states we considered.
Efficacy of Advance Care Planning Videos for Patients: A Randomized Controlled Trial in Cancer, Heart, and Kidney Failure Outpatient Settings
Authors: Douglas Maureen L. , Simon Jessica , Davison Sara N. , Biondo Patricia , Ghosh Sunita , Kassam Aliya , Fassbender Konrad 
Published: January 2021

Background Patient videos about advance care planning (ACP; hereafter “Videos”), were developed to support uptake of provincial policy and address the complexity of patients’ decision-making process. We evaluate self-administered ACP Videos, compare the studies’ choice of outcomes, show correlations between the patients’ ACP actions, and discuss implications for health care policy. Objective To test the efficacy of the Videos on patients’ ACP/goals of care designation conversations with a health care provider. Design, Setting, and Participants Using a 2-arm, 1:1 randomized controlled trial, we recruited outpatients with a diagnosis of kidney failure, heart failure, metastatic lung, gastrointestinal, or gynecological cancer from 22 sites. Analysis followed the intention-to-treat principle. Interventions Videos describing the ACP process and illustrating the resuscitative, medical, and comfort levels of care. Main Outcomes and Measures The primary outcome was the proportion of participants who reported having an ACP/goals of care designation (GCD) conversation with a health care provider by 3 mo. Outcomes were measured using the Behaviours in Advance Care Planning and Actions Survey, an online survey capturing ACP attitudes, processes, and actions. Results We analyzed 241 and 217 participants at baseline and 3 mo, respectively. The proportion of participants who had an ACP/GCD conversation with a health care provider by 3 mo was significantly different between study arms (46% intervention; 32% control; adjusted odds ratio, 1.83; P = 0.032). Adjusted for the quality of conversations, there was no significant difference. Conclusions Videos as stand-alone tools do not engage individuals in high-quality ACP. Pragmatic trials are necessary to evaluate their impact on downstream outcomes when integrated into intentional, comprehensive conversations with a health care provider. Considering the strong correlation between 2 activities (physicians discussing options, patients telling health care providers preferences), policy should focus on empowering patients to initiate these conversations.