bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling
Authors: Dourson Adam J. , Ford Zachary K. , Green Kathryn J. , McCrossan Carolyn E. , Hofmann Megan C. , Hudgins Renita C. , Jankowski Michael P. 
Published: April 2021

A number of cellular systems work in concert to modulate nociceptive processing in the periphery, but the mechanisms that regulate neonatal nociception may be distinct compared with adults. Our previous work indicated a relationship between neonatal hypersensitivity and growth hormone (GH) signaling. Here, we explored the peripheral mechanisms by which GH modulated neonatal nociception under normal and injury conditions (incision) in male and female mice. We found that GH receptor (GHr) signaling in primary afferents maintains a tonic inhibition of peripheral hypersensitivity. After injury, a macrophage dependent displacement of injury-site GH was found to modulate neuronal transcription at least in part via serum response factor (SRF) regulation. A single GH injection into the injured hindpaw muscle effectively restored available GH signaling to neurons and prevented acute pain-like behaviors, primary afferent sensitization, and neuronal gene expression changes. GH treatment also inhibited long-term somatosensory changes observed after repeated peripheral insult. Results may indicate a novel mechanism of neonatal nociception.SIGNIFICANCE STATEMENTAlthough it is noted that mechanisms of pain development in early life are unique compared with adults, little research focuses on neonatal-specific peripheral mechanisms of nociception. This gap is evident in the lack of specialized care for infants following an injury including surgeries. This report evaluates how distinct cellular systems in the periphery including the endocrine, immune and nervous systems work together to modulate neonatal-specific nociception. We uncovered a novel mechanism by which muscle injury induces a macrophage-dependent sequestration of peripheral growth hormone (GH) that effectively removes its normal tonic inhibition of neonatal nociceptors to promote acute pain-like behaviors. Results indicate a possible new strategy for treatment of neonatal postsurgical pain.
Comparison of the diagnostic accuracy of 18F-Fluorocholine PET and 11C-Methionine PET for parathyroid localization in primary hyperparathyroidism: a systematic review and meta-analysis
Authors: Bioletto Fabio , Barale Marco , Parasiliti-Caprino Mirko , Prencipe Nunzia , Berton Alessandro Maria , Procopio Massimo , Deandreis Désirée , Ghigo Ezio 
Published: April 2021

Background
Primary hyperparathyroidism is characterized by an autonomous hypersecretion of parathyroid hormone by one or more parathyroid glands. Preoperative localization of the affected gland(s) is of key importance in order to allow minimally invasive surgery. At the moment, 11C-Methionine and 18F-Fluorocholine PET studies appear to be among the most promising second-line localization techniques; their comparative diagnostic performance, however, is still unknown.

Methods
PubMed/Medline and Embase databases were searched up to October 2020 for studies estimating the diagnostic accuracy of 11C-Methionine PET or 18F-Fluorocholine PET for parathyroid localization in patients with primary hyperparathyroidism. Pooled sensitivity and positive predictive value were calculated for each tracer on a 'per-lesion' basis and compared using a random-effect model subgroup analysis.

Results
In total, 22 studies were finally considered in the meta-analysis. Of these, 8 evaluated the diagnostic accuracy of 11C-Methionine and 14 that of 18F-Fluorocholine. No study directly comparing the two tracers was found. The pooled sensitivity of 18F-Fluorocholine was higher than that of 11C-Methionine (92% vs 80%, P  < 0.01), while the positive predictive value was similar (94% vs 95%, P  = 0.99). These findings were confirmed in multivariable meta-regression models, demonstrating their apparent independence from other possible predictors or confounders at a study level.

Conclusion
This was the first meta-analysis that specifically compared the diagnostic accuracy of 11C-Methionine and 18F-Fluorocholine PET for parathyroid localization in patients with primary hyperparathyroidism. Our results suggested a superior performance of 18F-Fluorocholine in terms of sensitivity, while the two tracers had comparable accuracy in terms of positive predictive value.
Can preoperative ultrasound predict extrathyroidal extension of differentiated thyroid cancer?
Authors: Lamartina Livia , Bidault Sophie , Hadoux Julien , Guerlain Joanne , Girard Elizabeth , Breuskin Ingrid , Attard Marie , Suciu Voichita , Baudin Eric , Al Ghuzlan Abir , Leboulleux Sophie , Hartl Dana 
Published: April 2021

Objective
The presence of extrathyroidal extension (ETE) is generally considered as an indication for total thyroidectomy for differentiated thyroid cancer. The accuracy of neck ultrasound for the diagnosis of ETE is controversial. The aim of this study was to assess the diagnostic accuracy of preoperative ultrasound evaluation of ETE.

Methods
The retrospective and observational study of consecutive patients operated between 2016 and 2019 for cytologically suspicious or indeterminate thyroid nodules were analyzed. US images obtained preoperatively were retrospectively reviewed to identify signs of minimal or gross ETE. Histology was considered as the golden standard for diagnosis of ETE. The sensitivity, specificity, positive (PPV) and negative predictive values (NPV), and accuracy of US were evaluated.

Results
A cohort of 305 patients (75% females, median age 48 years) with 378 nodules (median size 18 mm) was studied. Seventy-five percent of the nodules (n = 228) were malignant on histology and ETE was present in 106 cases (28%): 83 minimal ETE and 23 gross ETE. Suspicion of minimal ETE on preoperative ultrasound was found in 50 (13%) with a sensitivity of 30%, a specificity of 93%, a PPV of 62% and an NPV of 78%, with an accuracy of 76%. Gross ETE on ultrasound was found in 19 (5%) nodules with a sensitivity of 78%, a specificity of 99.7% a PPV of 94.7% an NPV of 98.6% and an accuracy of 98%.

Conclusions
Preoperative US is very specific and accurate in diagnosing gross ETE which impacts the extent of initial surgery for thyroid cancers.
Effects of endogenous GIP in patients with type 2 diabetes
Authors: Stensen Signe , Gasbjerg Lærke S , Krogh Liva L , Skov-Jeppesen Kirsa , Sparre-Ulrich Alexander H , Jensen Mette H , Dela Flemming , Hartmann Bolette , Vilsbøll Tina , Holst Jens J , Rosenkilde Mette M , Christensen Mikkel B , Knop Filip K 
Published: April 2021

Objective
The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabolism in patients with type 2 diabetes using a selective GIP receptor antagonist and hypothesized that the effects of endogenous GIP were preserved.

Design
A randomized, double-blinded, placebo-controlled, crossover study.

Methods
Ten patients with overweight/obesity and type 2 diabetes (mean±s.d.; HbA1c 52 ± 11 mmol/mol; BMI 32.5 ± 4.8 kg/m2) were included. We infused a selective GIP receptor antagonist, GIP(3-30)NH2 (1200 pmol/kg/min), or placebo (saline) during two separate, 230-min, standardized, liquid mixed meal tests followed by a meal ad libitum. Subcutaneous adipose tissue biopsies were analyzed.

Results
Compared with placebo, GIP(3-30)NH2 reduced postprandial insulin secretion (Δbaseline-subtracted area under the curve (bsAUC)C-peptide% ± s.e.m.; −14 ± 6%, P = 0.021) and peak glucagon (Δ% ± s.e.m.; −11 ± 6%, P = 0.046) but had no effect on plasma glucose (P = 0.692). Suppression of bone resorption (assessed by circulating carboxy-terminal collagen crosslinks (CTX)) was impaired during GIP(3-30)NH2 infusion compared with placebo (ΔbsAUCCTX; ±s.e.m.; −4.9 ± 2 ng/mL × min, P = 0.005) corresponding to a ~50% reduction. Compared with placebo, GIP(3-30)NH2 did not affect plasma lipids, meal consumption ad libitum or adipose tissue triglyceride content.

Conclusions
Using a selective GIP receptor antagonist during a meal, we show that endogenous GIP increases postprandial insulin secretion with little effect on postprandial glycaemia but is important for postprandial bone homeostasis in patients with type 2 diabetes.
The Problem of Transworld Identity: in Defence of Essentialism
Authors: Gricius Pranciškus 
Published: April 2021

In this article, the problem of transworld identity – that is the question, if and how it is possible to ground the intuition that the same individual exists in more than one possible world – is solved by arguing that individuals have essences. First of all, it is claimed that the concept of transworld identity is desirable since it betters both global pan-essentialism and counterpart theory. Then, necessary terminology for successful understanding of the transworld identity problem is introduced. Afterwards, it is contended that the well-known Chisholm’s paradox for transworld identity can be resolved by appealing to individual essences. It is argued that if extreme haecceitism is true, then essences of individuals are non-qualitative and hence haecceitist switches are ontologically grounded. On the other hand, if reductionism is true, then essences of individuals are qualitative and hence haecceitist switches are impossible. Finally, it is shown that by referring to individual essences across possible worlds it is possible to solve the problem of cross-world identification.
The Fourth Checklist of Ukrainian Lichen-Forming and Lichenicolous Fungi with Analysis of Current Additions
Authors: Kondratyuk S. Y. , Popova L. P. , Khodosovtsev O. Y. , Lőkös L. , Fedorenko N. M. , Kapets N. V. 
Published: April 2021

The “Fourth checklist of lichen-forming and lichenicolous fungi of Ukraine”, including 2150 accepted scientific names based on published records as well as analysis of current additions are provided. Current additions include 439 taxa newly recorded for Ukraine after the third checklist of lichens of Ukraine by Kondratyuk et al. (2010) and 262 nomenclatural novelties. Annotations to each taxon of 318 newly recorded to Ukraine are provided in the style of the second checklist by Kondratyuket al. (1998), i.e. data on phytogeographical regions and administrative districts (oblasts) of Ukraine as well as references to published papers are provided. Among current additions 99 taxa were annotated in the Checklist of lichenicolous fungi of Ukraine by Darmostuk and Khodosovtsev (2017) and consequent references to the latter are provided.The conclusion confirms the earlier recommendation that national checklists of lichens are to be re-published more often than once a decade.
Penegakan Hukum Administrasi Terhadap Ketidakpatuhan Amdal
Authors: Hardono Bagus Setiawan , Nasrullah Nasrullah , Hidayat Beni 
Published: April 2021

Hukum merupakan perangkat untuk mengatur dan memuat sanksi bagi pelanggarnya. Demikian juga pentingnya kehadiran hukum yang jelas dan tegas dalam masalah lingkungan merupakan faktor kuat dalam mendorong penegakan hukum lingkungan di Indonesia. Dengan penerapan hukum yang baik diharapkan bisa memberi efek jera terhadap pelanggar agar supaya tercipta lingkungan yang baik bagi kepentingan bersama. Dalam permasalahan lingkungan diatur bahwa setiap kegiatan/usaha harus membuat izin lingkungan sebelum melaksanakan kegiatan/usahanya. Tujuan penelitian ini adalah untuk mengetahui bagaimana penegakan Hukum Administrasi dalam hal kewajiban Analisis Mengenai Dampak Lingkungan (AMDAL) di Kota Yogyakarta dan kendala dalam penegakan Hukum Administrasi dalam hal Analisis Mengenai Dampak Lingkungan. Penelitian masuk dalam tipologi penelitian hukum empiris. Data penelitian dikumpulkan dengan cara studi pustaka dan wawancara, kemudian diolah menjadi bentuk deskripsi analisis. Dari penelitian ini didapatkan bahwa pemerintah Kota Yogyakarta dalam penegakan hukum perihal AMDAL lebih mengupayakan penegakan hukum yang bersifat prefentif dibandingkan upaya represif. Hal ini dilakukan untuk menjaga stabilitas ekonomi yang ada di Kota Yogyakarta. Adapun kendala dalam penegakan hukumnya adalah kendala yang bersifat yuridis yaitu peraturan yang terlalu banyak hingga membuat pelaku usaha/pemrakarsa kesulitan dalam pembuatan izin lingkungan. Selain itu, masyarakat yang belum memahami pentingnya menjaga dan melestarikan lingkungan membuat banyak kegiatan atau usaha yang mendatangkan dampak buruk bagi lingkungan.
Representações sociais sobre suicídio
Authors: Calile Otávio Henrique Braz de Oliveira , Chatelard Daniela Scheinkman 
Published: April 2021

Essa é uma pesquisa quali-quantitativa, realizada em 2019, em Brasília, DF, com objetivo de verificar e descrever as representações sociais de estudantes de psicologia sobre o suicídio. Utilizou-se questionários de evocação com justificativas em campo livre. Os dados foram interpretados com procedimentos estatísticos propostos pela Análise Prototípica. Participaram 170 acadêmicos do segundo ao quarto período, de uma universidade privada. Os estudantes tinham entre 18 e 50 anos, sendo 89% mulheres e 11% são homens. Dentre os principais valores: Classe 1: 19,6%; Classe 2:14,44; Classe 3:26,1; Classe 4:26,8 e Classe 5:13,1); e, os dados provenientes de entrevistas permitiram a construção de duas categorias: Depressão e suporte social e, Sofrimento e fraqueza. As representações sociais do suicídio para os estudantes de psicologia são estruturadas com fundamento nos seguintes elementos do núcleo central: morte, dor, sofrimento, depressão, medo, pressão e tristeza. Entretanto, quando os participantes são instados a evocar termos que atribuem aos colegas, os elementos pressão e medo não aparecem mais, surgindo, então, a palavra fraqueza.
Bioconversion of Shrimp Shell Waste into Compost Preparation and its Plant Growth Study
Authors: Abirami S. , Gnanamuthu G. , Nagarajan D. 
Published: April 2021

Background: The fishing sector plays an important role in the global economy. The development of this sector is related to environmental issues, in particular to waste management. Indeed, the quantity of the halieutic waste are considered at several thousand tons of waste a year. Waste management is a solution to maintain an area with ecological harmony, but still can produce economic benefits that are beneficial to social welfare. Chitinases are enzymes that degrade chitin. Chitinase contribute to the generation of carbon and nitrogen in the ecosystem from shrimp shell wastes. Chitin and chitosan are naturally-occurring compounds that have potential to be used in agriculture. The present study was designed to prepare the shrimp shell waste compost (SSC) and also to analyse the enhancement growth of Ladies finger plant by using shrimp shell waste compost (SSC), shrimp shell waste compost (SSC) +cow dung (CD) and along with coir pith (CP). Methods: This experiment was conducted within the period of 2017-2018 in Department of Microbiology, Kamaraj college, Thoothukudi. 1Kg of dried shrimp shell waste powder was used for the compost preparation using chitinolytic bacteria Bacillus licheniformis SSCL10. The present study shrimp shell wastes were composted into manure with adding chitinolytic Bacillus licheniformis SSCL10. After 90 days of composting, the compost was dried at room temperature and used as manure for plant study. The growth study of ladies finger (Abelmoschus esculents L.) was analyzed in shrimp shell compost and also along with other composts (SSC + CD and SSC + CD+CP). Result: In our study, nitrogen, phosphorus and potash content were increased in the shrimp shell composts (SSC) with adding chitinase producing bacterium (Bacillus licheniformis SSCL10) when compared with control soil. The maximum plant growth performances were showed in the SSC+CD (cow dung) compared to combination of CP (coir pith), shrimp shell composts (SSC) alone and control. So shrimp shell compost is used as supplements for other compost to induce plant growth performances.
Determinant factors of depression in beta major thalassemia children
Authors: SURYAWAN AHMAD , Ningtiar Hapsari Widya , IRWANTO IRWANTO , UGRASENA I Dewa Gede 
Published: April 2021

Thalassemia is a chronic disease with long-term treatment that increases the potential for impact on physical, cognitive, and psychological conditions. About 80% of patients with major thalassemia have at least one psychiatric disorder, depression is one of the most frequently reported, especially in prepubertal and puberty periods. The aim of this study is to evaluate determinant factors of depression in beta mayor thalassemia children. This was a cross-sectional study on patients aged 9 to 17 years at hematology outpatient clinic in Dr. Soetomo General Hospital from September to Desember 2018. Level of depression determinded by Children Depression Inventory (CDI) questionnaire. The data were collected and analyzed using using the IBM SPSS Statistics version 21. It is statistically significant with p<0.05. Forty-five participants were included in this study, 15 participants with mild depression and 30 participants without depression. Gender (p=0.462), age of diagnosis (p=0.385), frequency of tranfussion (p=0.065), family history of depression (p=0,350), physical change (p=0.711), duration of illness (p=0.674) have no significant value as a determinant factor while complication (p=0.049) and serum cortisol level (p=0.037) had significant value as determinant factors of depression in Beta Major Thalassemia children. Mild depression is more common in thalassemia patients who experience complications and had high serum cortisol levels
Radiology Perspective One-Year Study of Hirschsprung Disease
Authors: Tjan Anastasia 
Published: April 2021

Hirschsprung disease is a rare developmental disorder of the enteric nervous system. This researched purpose to give an epidemiological database and current trend analysis from radiological perspective of Hirschsprung disease at our center. A prospective descriptive study was conducted for a year in 2017 at Sanglah Public General Hospital Bali. Colon in loop examination using either water-soluble or barium was conducted. All baseline characteristics, contras media used, and HD type were the parameter being evaluated in this study. Hirschsprung accounted for 2.16% from all 1018 newborn. Male is 3.4 times more prone to Hirschsprung disease. Age distribution predominant during 0 – 4 weeks after birth (36.4%). Ultrashort, short, long segments were 45.5%, 45.5%, and 9% respectively. Contras media used was mainly barium rather than water soluble 8:3, due to standard operating procedure adapted by some pediatric surgeon. Ultrashort and short segment HD has the same contribution. Barium is dominated at our center although water soluble is chosen in most literature for infant, due to its ability as diagnostic as well as therapeutic. Hence further research should be done to support and change the perspective in making the diagnosis.
KAJIAN PERSEPSI DAN MOTIVASI PENGUNJUNG UNTUK PENGEMBANGAN WISATA ALAM DI PENANGKARAN RUSA TAHURA WAN ABDUL RACHMAN
Authors: Agung Tiara Avissa , Herwanti Susni 
Published: April 2021

Tourism is a promising option for developing countries in order to create a prosperous society. Indonesia with its natural wealth and hospitality has the potential to be one of the world's destination countries. One of the potential natural attractions that can be developed for tourism in Lampung Province is the Deer Captive of the Great Forest Park (Tahura) Wan Abdul Rachman. The aims of this study were to determine the perception and motivation of visitors to visit the Deer Captive of Tahura Wan Abdul Rachman. The information is important to provide input for further planning and management of the Deer Captive of Tahura Wan Abdul Rachman. The research was carried out in the Deer Captive of Tahura Wan Abdul Rachman. The study was conducted by interviewing visitors and sampling was done using incidental sampling techniques. The results showed that visitors' perceptions of the uniqueness of Timor Deer were very good, while for visitors' perceptions of accessibility it was stated to be quite good, perceptions of facilities were also stated to be good, and the perception of the addition of tour guides was very good to be included as ancillary services. There are two factors that motivate visitors, namely drivers and pullers. The driving factor for visitors is to increase knowledge about Cervus timorensis and visitors' attracting factors, namely the attraction of Cervus timorensis.
PERBANDINGAN KEANEKARAGAMAN JENIS BURUNG ANTARA LAHAN ASLI KEBUN KELAPA SAWIT DAN LAHAN YANG TELAH DITANAMI KELAPA SAWIT
Authors: Ramlah Sitti , Santosa Yanto , Santoso Nyoto 
Published: April 2021

The expansion of the oil palm plantation establishment has been arousing someaccusation regarding the loss of biodiversity especially on bird diversity. Hence, this study was conducted to compare the bird diversity between oil palm plantation and its origin land cover. The study was conducted on May 2018 in 2 oil palm plantation in the West Sulawesi and its origin land cover around the plantation area. The observation was done twice a day, in the morning and afternoon, with 3 repetitions. The data was then analyzed using richness index, Evenness index and also index similarity to identify the similarities of bird species similarity between land covers. The result show that the highest number of bird species was found in theoil palm plantation of the company 1 which also happen for the evenness and richness indices. While, the similarity index showed the value about 0.42-0.46. Overall, the land cover changes also causing a change in the bird species composition.
PENDUGAAN KANDUNGAN KARBON TEGAKAN AKASIA (Acacia mangium WILD) BERBASIS BEF DI PT INHUTANI III SEBUHUR KALIMANTAN SELATAN
Authors: Kanti Rina 
Published: April 2021

The purpose of this research is to estimate the potential of carbon in the standing of Acacia mangium Willd in Areal PT INHUTANI III Sebuhur of South Kalimantan. The research method of using the ALOS satellite imagery is georectification so that the image position corresponds to the actual position in the field and to see the uniformity of the sample in the NDVI, a descriptive statistical test in the respective NDVI and Klas diameter. Based on the NDVI classification on Citra Alos in 2012, the land area of the wooded area of PT INHUTANI III Sebuhur is 8,183.18 ha. Results Biomass Expansion Factor (BEF) based on 4 klas diameter with polynomial equation Y =-0.0057 X2 + 0.014 x + 1.2623; R ² = 0.9621 is a klas 5 – 10 diameter in the total of 1,272, Klas, 10 – 15 diameter in total 1.263, klas, in diameter 15 – 20 in total 1.258 and Klas > diameter 20 totalnya1,226. The result of total carbon potential in wooded areas of PT INHUTANI III Sebuhur is 31,497.11 ton/Ha, so the average carbon potential of 3.8489 Ton/Ha. Meanwhile, the potential carbon (ton/ha) based on NDVI 2-7 according to the logarithmic equation Y = 4.7925 ln (X)-2.0321; R ² = 0.9167, with Y is the potential carbon ton/ha and X is NDVI Klas is Klas NDVI 2 1.0462 tons/ha, Klas NDVI 3 of 3.7918 tons/ha, Klas NDVI 4 of 4.7479 tons/ha, Klas NDVI 5 of 4.7213 tons/ha, Klas NDVI 6 of 7.0632 tons/ha, and Klas NDVI 7 of 5.2875 ton/ha.