bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge and attitudes regarding amblyopia among parents in Jeddah, Saudi Arabia: a cross-sectional study
Authors: Basheikh Ahmed , Alhibshi Nizar , Bamakrid Motaz , Baqais Rasha , Basendwah Mohammed , Howldar Sara 
Published: February 2021

Abstract
Objectives
To assess parents’ perceptions about amblyopia and its causes, symptoms, risk factors, treatments, and the importance of follow-up and to evaluate their awareness regarding the consequences and critical complications.

Results
Parents or their companions (n = 401) were surveyed, and 52.9% were mothers, 81.8% of mothers and 85.7% of fathers were highly educated (diploma, college or university degree), and 58 (14.5%) had a child who was afflicted with amblyopia. The knowledge subscale (nine items) showed acceptable reliability. Twenty percent of the participants declared having adequate knowledge about amblyopia, but assessment by item showed low percentages of an adequate knowledge level, ranging from 0% for amblyopia causes, 35.9% for definition, and 59.9% for whether amblyopia is a hereditary disease. Thus, the rate of adequate knowledge (Knowledge Score ≥ 8) was 25.9%, and was associated with parents’ nationality (p < 0.05) and self-declared knowledge about amblyopia (p < 0.001). No significant difference was observed among respondents who had a child with amblyopia. There was a lack of knowledge about basic information and different aspects of the disease, which emphasized the relevance of school-based screening programs and adequate use of trustworthy internet resources using easily understood medical information.
5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients
Authors: Chen Hang-Yu , Zhang Wei-Long , Zhang Lei , Yang Ping , Li Fang , Yang Ze-Ruo , Wang Jing , Pang Meng , Hong Yun , Yan Changjian , Li Wei , Liu Jia , Xu Nuo , Chen Long , Xiao Xiu-Bing , Qin Yan , He Xiao-Hui , Liu Hui , Zhu Hai-Chuan , He Chuan , Lin Jian , Jing Hong-Mei 
Published: February 2021

AbstractBackgroundAlthough R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are responsive to the scheme, and there is no effective method to predict treatment response.MethodsWe utilized 5hmC-Seal to generate genome-wide 5hmC profiles in plasma cell-free DNA (cfDNA) from 86 DLBCL patients before they received R-CHOP chemotherapy. To investigate the correlation between 5hmC modifications and curative effectiveness, we separated patients into training (n = 56) and validation (n = 30) cohorts and developed a 5hmC-based logistic regression model from the training cohort to predict the treatment response in the validation cohort.ResultsIn this study, we identified thirteen 5hmC markers associated with treatment response. The prediction performance of the logistic regression model, achieving 0.82 sensitivity and 0.75 specificity (AUC = 0.78), was superior to existing clinical indicators, such as LDH and stage.ConclusionsOur findings suggest that the 5hmC modifications in cfDNA at the time before R-CHOP treatment are associated with treatment response and that 5hmC-Seal may potentially serve as a clinical-applicable, minimally invasive approach to predict R-CHOP treatment response for DLBCL patients.
Degenerative spine disease: Italian position paper on acquisition, interpretation and reporting of Magnetic Resonance Imaging
Authors: Pizzini Francesca B. , Poletti Mattia , Beltramello Alberto , Muto Mario , Splendiani Alessandra , Mehrabi Sara , Costanzo Giuseppe , Vitiello Vincenzo , Barile Antonio , Colagrande Stefano , Mansueto Giancarlo , Bastianello Stefano 
Published: February 2021

AbstractObjectiveTo promote a better radiological interpretation of spine degeneration, a consistent standardization of the acquisition, interpretation and description of Magnetic Resonance Imaging (MRI) l findings.Materials and methodsIn order to achieve this objective, a consensus among experts in imaging of degenerative spine disease (DSD) from Italian radiological societies (SIRM—Italian Society of Radiology, AINR—Italian Association of Neuroradiology) was achieved. The representatives of the Italian inter-societal working group examined the literature produced by European/American task forces on optimizing the study sequences, classification of degenerative disc changes, spondylo-arthrosis, osteochondrosis, synovial and ligament pathologies of the spinal column, and on canal and foraminal stenosis. The document-resulted from the consensus between experts—was then presented to the scientific societies of Neurosurgery (SINCH) and Orthopedics and Traumatology (SIOT) for their approval.ResultsThis position paper presents a proposal for an optimized MRI protocol for studying DSD and provides a glossary of terms related to this pathology and indications on their use. The international terminological recommendations have been translated and adapted to the Italian language and clinical practice and clinical cases have been used to illustrate some of the main classifications.ConclusionsThis revision of international DSD guidelines/recommendations and consensus made it possible to (1) update the nomenclature to international standards and (2) harmonize the MRI protocol and description of radiological findings, adapting both (1, 2) to the Italian context. With this position paper we intend to contribute to an improvement of the communication among doctors and between physicians and their patients as well as the quality of the radiological reports.
Novel starter cultures Virgibacillus spp. selected from grasshopper sub shrimp paste to inhibit biogenic amines accumulation
Authors: Zhao Yirui , Sang Xue , Hao Hongshun , Bi Jingran , Zhang Gongliang , Hou Hongman 
Published: February 2021

AbstractControlling the content of biogenic amines (BAs) is critical to guarantee the safety of fermented aquatic products. The degradation characteristics and application potential of amine-negative starter cultures (Virgibacillus halodenitrificans CGMCC 1.18601: G25, Virgibacillus pantothenticus CGMCC 1.18602: G38) screened from grasshopper sub shrimp paste (Gssp) were studied. The enzymes of the two strains G25 and G38 that degrade BAs were amine oxidases (AOs) located on their respective cell membranes. The conditions that promoted the AO activity of Virgibacillus spp. were NaCl concentrations 5–10%, temperature 37 °C, pH 7.0 and ethanol concentrations 0–2%. Safety assessments (antibiotic susceptibility, biofilm activity and hemolytic activity) indicated that Virgibacillus spp. do not present a risk to human health, and this isolate can be confidently recommended as safe starter cultures for the food industry. Then, the two strains were cultured separately as starters and applied to the Gssp to analyze their influence on the flavor and quality of the product. As far as the bad flavors in Gssp such as sulfur-organic and sulf-chlor were concerned, the response values in the starter groups by G25 and G38 were significantly reduced by 39% and 65%, respectively. For the ability of strains to degrade BAs in Gssp, G25 degraded 11.1% of histamine, 11.3% of tyramine, 15.5% of putrescine and 4.1% of cadaverine; G38 significantly degraded 10.1% of histamine, 21.8% of tyramine, 18.1% of putrescine and 5.0% of cadaverine. These results indicated that the selected species could be used as starter cultures for the control of BA accumulation and degradation in Gssp.
Validation of the pediatric refractory septic shock definition: post hoc analysis of a controlled trial
Authors: Morin Luc , Ramaswamy Karthik Narayanan , Jayashree Muralidharan , Bansal Arun , Nallasamy Karthi , Tissieres Pierre , Singhi Sunit 
Published: February 2021

Abstract
Background
The European Society of Pediatric and Neonatal Intensive Care (ESPNIC) developed and validated a definition of pediatric refractory septic shock (RSS), based on two septic shock scores (SSS). Both bedside SSS (bSSS) and computed SSS (cSSS) were found to be strongly associated with mortality. We aimed at assessing the accuracy of the RSS definition on a prospective cohort from India.

Methods
Post hoc analysis of a cohort issued from a double-blind randomized trial that compared first-line vasoactive drugs in children with septic shock. Sequential bSSS and cSSS from 60 children (single-center study, 53% mortality) were analyzed. The prognostic value of the ESPNIC RSS definition was tested for 28-day all-cause mortality.

Results
In this septic shock cohort, RSS was diagnosed in 35 patients (58.3%) during the first 24 h. Death occurred in 30 RSS patients (85.7% mortality) and in 2 non-RSS patients (8% mortality), OR = 60.9 [95% CI: 10.5–676.2], p < 0.001 with a median delay from sepsis onset of 3 days [1.0–6.7]. Among patients diagnosed with RSS, the mortality was not significantly different according to vasopressors randomization. Diagnosis of RSS with bSSS and cSSS had a high discrimination for death with an area under the receiver operating curve of 0.916 [95% CI: 0.843–0.990] and 0.925 [95% CI: 0.845–1.000], respectively. High prognostic accuracy of the bSSS was found in the first hours following intensive care admission. The best interval of prognostication occurs after the 12th hour following treatment initiation (AUC 0.973 [95% CI: 0.925–1.000]).

Conclusions
The ESPNIC refractory septic shock definition accurately identifies, within the first 6 h of septic shock management, children with lethal outcome.
Energy-efficient offloading and resource allocation for mobile edge computing enabled mission-critical internet-of-things systems
Authors: Fu Yaru , Yang Xiaolong , Yang Peng , Wong Angus K. Y. , Shi Zheng , Wang Hong , Quek Tony Q. S. 
Published: February 2021

AbstractThe energy cost minimization for mission-critical internet-of-things (IoT) in mobile edge computing (MEC) system is investigated in this work. Therein, short data packets are transmitted between the IoT devices and the access points (APs) to reduce transmission latency and prolong the battery life of the IoT devices. The effects of short-packet transmission on the radio resource allocation is explicitly revealed. We mathematically formulate the energy cost minimization problem as a mixed-integer non-linear programming (MINLP) problem, which is difficult to solve in an optimal way. More specifically, the difficulty is essentially derived from the coupling of the binary offloading variables and the resource management among all the IoT devices. For analytical tractability, we decouple the mixed-integer and non-convex optimization problem into two sub-problems, namely, the task offloading decision-making and the resource optimization problems, respectively. It is proved that the resource allocation problem for IoT devices under the fixed offloading strategy is convex. On this basis, an iterative algorithm is designed, whose performance is comparable to the best solution for exhaustive search, and aims to jointly optimize the offloading strategy and resource allocation. Simulation results verify the convergence performance and energy-saving function of the designed joint optimization algorithm. Compared with the extensive baselines under comprehensive parameter settings, the algorithm has better energy-saving effects.
Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial
Authors: JamaliMoghadamSiahkali Saeidreza , Zarezade Besharat , Koolaji Sogol , SeyedAlinaghi SeyedAhmad , Zendehdel Abolfazl , Tabarestani Mohammad , Sekhavati Moghadam Ehsan , Abbasian Ladan , Dehghan Manshadi Seyed Ali , Salehi Mohamadreza , Hasannezhad Malihe , Ghaderkhani Sara , Meidani Mohsen , Salahshour Faeze , Jafari Fatemeh , Manafi Navid , Ghiasvand Fereshteh 
Published: February 2021

Abstract
Background
Vitamin C is an essential water-soluble nutrient that functions as a key antioxidant and has been proven to be effective for boosting immunity. In this study, we aimed to assess the efficacy of adding high-dose intravenous vitamin C (HDIVC) to the regimens for patients with severe COVID-19 disease.

Methods
An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lopinavir/ritonavir and hydroxychloroquine and the case group received HDIVC (6 g daily) added to the same regimen.

Results
There were no statistically significant differences between two groups with respect to age and gender, laboratory results, and underlying diseases. The mean body temperature was significantly lower in the case group on the 3rd day of hospitalization (p = 0.001). Peripheral capillary oxygen saturations (SpO2) measured at the 3rd day of hospitalization was also higher in the case group receiving HDIVC (p = 0.014). The median length of hospitalization in the case group was significantly longer than the control group (8.5 days vs. 6.5 days) (p = 0.028). There was no significant difference in SpO2 levels at discharge time, the length of intensive care unit (ICU) stay, and mortality between the two groups.

Conclusions
We did not find significantly better outcomes in the group who were treated with HDIVC in addition to the main treatment regimen at discharge.
Trial registration irct.ir (IRCT20200411047025N1), April 14, 2020
Time-Dependent Analysis of Precast Segmental Bridges
Authors: Giaccu Gian Felice , Solinas Davide , Briseghella Bruno , Fenu Luigi 
Published: February 2021

AbstractPrestressed segmentally constructed balanced cantilever bridges are often subjected to larger deflections than those predicted by calculations, especially for long-term effects. In this paper, the case of modular balanced cantilever bridges, which are prestressed segmental bridges obtained through a repetition of the same double cantilever, is investigated. The considered bridges are two typical cases of modular balanced cantilever both subjected to large deformations during their lifetime. In this case, due to the unusual employed static scheme, creep deflections indefinitely evolve over time particularly at the end of the cantilevers and in correspondence with the central joint. These remarkable deflections cause discomfort for vehicular traffic and in certain cases can lead to the bridge collapse. Important extraordinary maintenance interventions were necessary to restore the viability of the bridges and to replace the viaduct design configuration. To this aim, the static schemes of the structures were varied, introducing new constraints, new tendons, and carbon fiber reinforcements. In the present work, time analysis was performed to compare the time-dependent behavior of the bridge according to two different creep models, the CEB-FIP Model Code 2010 and the RILEM Model B3, with the real-time-dependent behavior of the bridge observed during its lifetime. The two different employed models exhibit different behaviors in terms of displacements and bending moments acting on the bridge. Interesting considerations are made on their reliability in simulating the long-term creep effects that evolve indefinitely over time. Moreover, retrofitting techniques have been proposed and modeled to predict their effectiveness in reducing time-dependent deflections.
Physical activity behaviors and attitudes among women with an eating disorder: a qualitative study
Authors: Brunet Jennifer , Del Duchetto Francis , Wurz Amanda 
Published: February 2021

Abstract
Background
Physical activity (PA) is an integral part of healthcare for the general population and individuals with psychiatric disorders. However, PA is significantly more complex for and related to both healthy (e.g., reduced anxiety and depressive symptoms) and unhealthy outcomes (e.g., intrusive, repetitive thoughts that lead to abnormally high levels of PA) among women with an eating disorder (ED). Consequently, many healthcare professionals recommend abstinence from PA during ED treatment. Despite this, women may remain engaged in PA during ED treatment or resume PA shortly thereafter. Little has been done to understand women’s PA behaviors and attitudes and to explore how they integrate PA into their lives during and after ED treatment. Thus, this study sought to explore PA behaviors and attitudes among women with an ED.

Methods
Nine women who self-reported receiving an ED diagnosis participated in semi-structured interviews, which were transcribed and analysed thematically.

Results
Six interrelated themes were constructed to represent participants’ PA experiences: PA as a lifestyle, PA can be beneficial, How I feel when I can’t do PA, Being cautious about PA, Reactions to healthcare professionals’ practice of recommending abstinence from PA during ED treatment, and PA programming thoughts.

Conclusions
Overcoming dysfunctional PA behaviors (e.g., engaging in abnormally high levels of PA) and attitudes (e.g., associating PA with caloric expenditure) can be a long and complicated journey for women with an ED. Nevertheless, women with an ED want PA to be integrated into their ED treatment protocol for two key reasons, namely to accrue the benefits associated with PA and to learn how to engage in PA in adaptive and healthy ways.
Noise in Otolaryngology – Head and Neck Surgery operating rooms: A systematic review
Authors: Sampieri Gianluca , Namavarian Amirpouyan , Levin Marc , Philteos Justine , Lee Jong Wook , Koskinen Anni , Lin Vincent , Lee John 
Published: February 2021

Objective Noise in operating rooms (OR) can have negative effects on both patients and surgical care workers. Noise can also impact surgical performance, team communication, and patient outcomes. Such implications of noise have been studied in orthopedics, neurosurgery, and urology. High noise levels have also been demonstrated in Otolaryngology-Head and Neck Surgery (OHNS) procedures. Despite this, no previous study has amalgamated the data on noise across all OHNS ORs to determine how much noise is present during OHNS surgeries. This study aims to review all the literature on noise associated with OHNS ORs and procedures. Methods Ovid Medline, EMBASE Classic, Pubmed, SCOPUS and Cochrane databases were searched following PRISMA guidelines. Data was collected on noise measurement location and surgery type. Descriptive results and statistical analysis were completed using Stata. Results This search identified 2914 articles. Final inclusion consisted of 22 studies. The majority of articles analyzed noise level exposures during mastoid surgery (18/22, 82%). The maximum noise level across all OHNS ORs and OHNS cadaver studies were 95.5 a-weighted decibels (dBA) and 106.6 c-weighted decibels (dBC), respectively ( P = 0.2068). The mean noise level across all studies was significantly higher in OHNS cadaver labs (96.9 dBA) compared to OHNS ORs (70.1 dBA) ( P = 0.0038). When analyzed together, the mean noise levels were 84.9 dBA. Conclusions This systematic review demonstrates that noise exposure in OHNS surgery exceeds safety thresholds. Further research is needed to understand how noise may affect team communication, surgical performance and patient outcomes in OHNS ORs. Graphical Abstract
Latent profiles of patients with borderline pathology based on the alternative DSM-5 model for personality disorders
Authors: Gamache Dominick , Savard Claudia , Leclerc Philippe , Payant Maude , Côté Alexandre , Faucher Jonathan , Lampron Mireille , Tremblay Marc 
Published: February 2021

Abstract
Background
There have been multiple attempts to try to parse out heterogeneity within borderline pathology by identifying patient subtypes; thus far, these works have yielded few consistent results. Recent developments in the operationalization of borderline pathology may provide new opportunities to identify clinically and conceptually meaningful subgroups of patients. The Alternative DSM-5 Model for Personality Disorders (AMPD) offers a categorical-dimensional operationalization of Borderline personality disorder (BPD) that has yet to be tested for identification of patient subgroups. The purpose of the present study is to test whether the combination of the Criterion A elements (pertaining to level of severity) and the seven pathological facets from Criterion B that define BPD in the AMPD can yield meaningful patient profiles.

Methods
A total of 211 outpatients from a specialized PD treatment program (133 women, Mage = 33.66, SD = 10.97) were selected based on the presence of at least moderate borderline pathology according to cutoffs recently proposed for the Borderline Symptom List-23. Valid Criterion A (Self and Interpersonal Functioning Scale) and B (Personality Inventory for DSM-5 Faceted Brief Form) self-reports were administered to measure elements and facets that define BPD in the AMPD model; these variables were used as indicators in a latent profile analysis (LPA).

Results
The optimal solution generated by LPA yielded four distinct profiles: (a) Borderline traits; (b) Moderate pathology with Impulsivity; (c) Moderate pathology with Identity problems and Depressivity; and (d) Severe pathology. Clinically meaningful distinctions emerged among profiles on AMPD indicators and external variables relevant to PD, especially aggression and impulsivity.

Conclusions
Profiles reflected both the “severity” and “style” components imbedded within Criterion A and B of the AMPD, as they were mainly distinguished by a continuum of severity but also by some meaningful qualitative differences that may have important clinical implications for treatment planning and contracting. Results also suggest that the four Criterion A elements have independent value to identify important differences in patients with borderline pathology. They also highlight that some Criterion B facets that define BPD in the AMPD may be especially important to identify subgroups of patients, mainly Impulsivity and Depressivity.
Universal health coverage and COVID-19: recent developments and implications
Authors: Hussain Rabia , Arif Sara 
Published: February 2021

AbstractUniversal health coverage (UHC) is meant to access the key health services including disease prevention, treatment, rehabilitation, and health promotion. UHC varies according to demographics, epidemiology, and technology-based trends, as well as according to people’s expectations. Globally, the transition towards UHC has been associated with the intent of improving accessibility and affordability of healthcare. The COVID-19 pandemic has disrupted the health systems of even the most developed economies of the world in an unprecedented manner. The situation is also very challenging for the countries with the existing health inequities as well as the countries with the developing healthcare systems. This has amplified the need to accelerate efforts to build strong and resilient health systems to achieve progress towards UHC. This commentary discusses a global overview of UHC in the wake of COVID19. It also highlights the initiatives taken by Pakistan to promote the goals of UHC.