bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Give me perfection or nothing!”: The impact of perfectionism on product evaluation as moderated by secrecy effect and name volatility
Authors: Ker Wen‐Ying , Kao Danny Tengti 
Published: July 2021

AbstractWhile perfectionism has been extensively explored in psychiatric and clinical psychology literature, theoretical understanding of the effects of perfectionism on consumers' evaluations of the advocated product is promising but underexplored. Therefore, this research aims to employ cases of perfectionism and secrecy effect to examine whether name volatility can moderate consumers' product evaluations. The experiment was designed to examine the effect of perfectionism on product evaluation by presenting a variety of advertisements that differed in name volatility and secrecy context manipulation. In the experiment, a total of 217 participants were randomly assigned to a 2 (secrecy context: secret vs. non‐secret) × 2 (name volatility: volatile vs. calm) × 2 (perfectionism: self‐oriented vs. socially prescribed) between‐subjects factorial design. Results demonstrated that for consumers who showed variances in the type of perfectionism, advertisements characterized by different secrecy (secret context vs. non‐secret context) and name volatility (volatile vs. calm) will lead to differential product evaluations. This research takes up the call to extend the limited attention given to perfectionism in the domain of marketing. Specifically, this research aims to explore how consumers' perfectionism affects their product evaluations and the moderating effects of secrecy and name volatility.
Characterization of Fluorescent Proteins with Intramolecular Photostabilization**
Authors: Henrikus Sarah S. , Tassis Konstantinos , Zhang Lei , van der Velde Jasper H. M. , Gebhardt Christian , Herrmann Andreas , Jung Gregor , Cordes Thorben 
Published: July 2021

AbstractGenetically encodable fluorescent proteins have revolutionized biological imaging in vivo and in vitro. Despite their importance, their photophysical properties, i. e., brightness, count‐rate and photostability, are relatively poor compared to synthetic organic fluorophores or quantum dots. Intramolecular photostabilizers were recently rediscovered as an effective approach to improve photophysical properties of organic fluorophores. Here, direct conjugation of triplet‐state quenchers or redox‐active substances creates high local concentrations of photostabilizer around the fluorophore. In this paper, we screen for effects of covalently linked photostabilizers on fluorescent proteins. We produced a double cysteine mutant (A206C/L221C) of α‐GFP for attachment of photostabilizer‐maleimides on the β‐barrel near the chromophore. Whereas labelling with photostabilizers such as trolox, a nitrophenyl group, and cyclooctatetraene, which are often used for organic fluorophores, had no effect on α‐GFP‐photostability, a substantial increase of photostability was found upon conjugation to azobenzene. Although the mechanism of the photostabilizing effects remains to be elucidated, we speculate that the higher triplet‐energy of azobenzene might be crucial for triplet‐quenching of fluorophores in the blue spectral range. Our study paves the way for the development of fluorescent proteins with photostabilizers in the protein barrel by methods such as unnatural amino acid incorporation.
Enzymatic Asymmetric Reduction of Unfunctionalized C=C Bonds with Archaeal Geranylgeranyl Reductases
Authors: Cervinka Richard , Becker Daniel , Lüdeke Steffen , Albers Sonja‐Verena , Netscher Thomas , Müller Michael 
Published: July 2021

AbstractThe asymmetric reduction of activated C=C bonds such as enones is well established for non‐enzymatic methods as well as in biocatalysis. However, the asymmetric reduction of unfunctionalized C=C bonds is mainly performed with transition metal catalysts whereas biocatalytic approaches are lacking. We have tested two FAD‐dependent archaeal geranylgeranyl reductases (GGR) for the asymmetric reduction of isolated C=C bonds. The reduction of up to four double bonds in terpene chains with different chain lengths and head groups was confirmed. Methyl‐branched E‐alkenes were chemoselectively reduced in the presence of cyclic, terminal or activated alkenes. Using a removable succinate “spacer”, farnesol and geraniol could be quantitatively reduced (>99 %). The reduction is strictly (R)‐selective (enantiomeric excess >99 %). Hence, GGRs are promising biocatalysts for the asymmetric reduction of unactivated isolated C=C bonds, opening new opportunities for the synthesis of enantiopure branched alkyl chains.
Multispectral hand features for secure biometric authentication systems
Authors: Bartuzi Ewelina , Trokielewicz Mateusz 
Published: July 2021

SummaryWith rapid growth of mobile‐based computing, reliable security and user authentication methods are necessary. This article proposes a proof‐of‐concept biometric authentication method utilizing hand images collected in different light spectra. An analysis of similarity between pattern of blood vessels extracted from near‐infrared images and thermal images and assessment of the correlation between individual biometric features contained in each image type is also performed. Results indicate a large potential of using thermal images in biometrics more extensively than now. Also proposed and evaluated are biometric recognition methods based on images of the hand acquired in visible light, near infrared, and using thermal infrared sensors. Two approaches were used to assess information content in images of each type: one based on texture descriptor and one employing convolutional neural networks. In an evaluation gathering data from 104 subjects, the former yielded the lowest equal error rate (EER) of , whereas the latter approach gave for thermal images. Finally, fusion of different‐spectra modalities increases accuracy and further reduces EER to . This is, to the authors' best knowledge, the first study exploring the concept of fusing different spectral representations of the human hand for the purpose of biometric recognition.
Effects of tillage methods on soil physical properties and maize growth in a saline–alkali soil
Authors: Chen Tianyu , Zhang Yifei , Fu Jian , Yang Li , Chi Yuxin , Yang Kejun , Wang Yufeng 
Published: July 2021

AbstractSoil sodicity and salinization is a major issues concerning agricultural production in northeast China. The effects of six treatments—no tillage (NT), no tillage and subsoiling (NTS), rotary and ridge tillage (RT), rotary and ridge tillage and subsoiling (RTS), rotary and flat tillage (FT), and rotary and flat tillage and subsoiling (FTS)—on soil physical and chemical properties and yields were compared from 2016 to 2018. The results showed that compared with the RT treatment, which is the traditional tillage method in this area, and the FT treatment, the NT treatment increased the soil water content (SWC) during the first‐leaf growth stage (V1). The use of subsoiling increased the average daily temperature and the soil thermal time (TTsoil). Subsoiling contributed to the growth and development of deep roots and increased leaf area index (LAI) to intercept more radiation. The NTS treatment increased grain yield of maize (Zea mays L.) by 2.7–15.2%, nitrogen use efficiency (NUE) by 4.2–14.4%, and water use efficiency (WUE) by 5.4–16.5% compared with RT. In conclusion, NTS soil management practices appear to be a sustainable approach to farming in the semiarid region of the Songnen Plain.
CMIP interacts with WT1 and targets it on the proteasome degradation pathway
Authors: Zhang Shao‐Yu , Fan Qingfeng , Moktefi Anissa , Ory Virginie , Audard Vincent , Pawlak Andre , Ollero Mario , Sahali Dil , Henique Carole 
Published: July 2021

AbstractBackgroundThe Wilms tumor 1 suppressor gene, WT1, is expressed throughout life in podocytes and is essential for their function. Downregulation of WT1 has been reported in podocyte diseases but the underlying mechanisms remain unclear. Podocyte injury is the hallmark of idiopathic nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults. An increase in the abundance of Cmaf‐inducing protein (CMIP) has been found to alter podocyte function, but it is not known whether CMIP affects WT1 expression.MethodsTranscriptional and post‐transcriptional regulation of WT1in the presence of CMIP was studied using transient transfection, mouse models, and siRNA handling.ResultsWe showed that overproduction of CMIP in the podocyte was consistently associated with a downregulation of WT1 according to two mechanisms. We found that CMIP prevented the NF‐kB‐mediated transcriptional activation of WT1. We demonstrated that CMIP interacts directly with WT1 through its leucine‐rich repeat domain. Overexpression of CMIP in the M15 cell line induced a downregulation of WT1, which was prevented by lactacystin, a potent proteasome inhibitor. We showed that CMIP exhibits an E3 ligase activity and targets WT1 to proteasome degradation. Intravenous injection of Cmip‐siRNA specifically prevented the repression of Wt1 in lipopolysaccharides‐induced proteinuria in mice.ConclusionsThese data suggest that CMIP is a repressor of WT1 and might be a critical player in the pathophysiology of some podocyte diseases. Because WT1 is required for podocyte integrity, CMIP could be considered a therapeutic target in podocyte diseases.
Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide
Authors: Hong Zhe , Xiang Zhendong , Zhang Pan , Wu Qiang , Xu Chengdang , Wang Xinan , Shi Guowei , Hong Zongyuan , Wu Denglong 
Published: July 2021

AbstractCastration‐resistant prostate cancer (CRPC) is the latest stage of PCa, and there is almost no effective treatment available for the patients with CRPC when next‐generation androgen deprivation therapy drugs, such as enzalutamide (ENZ), fail. The androgen receptor (AR) plays key roles in PCa and CRPC progression and drug resistance. Histone acetyltransferase 1 (HAT1) has recently been reported to be highly expressed in some tumors, such as lung carcinoma. However, what relationship between the AR and HAT1, and whether or how HAT1 plays roles in CRPC progression and drug resistance remain elusive. In the present study, we found that HAT1 is highly expressed in PCa cells, and the overexpression of HAT1 is linked with CRPC cell proliferation. Moreover, the HAT1 expression is positively correlated with the expression of AR, including both AR‐FL (full‐length) and AR‐V7 (variant 7), which is mainly mediated by a bromodomain containing protein 4 (BRD4) ‐mediated pathway. Furthermore, knockdown of HAT1 can re‐sensitize the response of CRPC cells to ENZ treatment in cells and mouse models. In addition, ascorbate was observed to decrease AR expression through downregulation of HAT1 expression. Collectively, our findings reveal a novel AR signaling regulation pathway in PCa and CRPC and suggest that HAT1 serves as a critical oncoprotein and an ideal target for the treatment of ENZ resistance in CRPC patients.
Plant‐eating carnivores: Multispecies analysis on factors influencing the frequency of plant occurrence in obligate carnivores
Authors: Yoshimura Hiroto , Hirata Satoshi , Kinoshita Kodzue 
Published: July 2021

AbstractPlant‐eating behavior is one of the greatest mysteries in obligate carnivores. Despite unsuitable morphological and physiological traits for plant consumption, the presence of plants in scat or stomach contents has been reported in various carnivorous species. However, researchers’ interpretations of this subject are varied, and knowledge about it is scarce, without any multispecies studies. This study assessed the extent of variation in the frequency of plant occurrence in scat and stomach contents, as well as its relationship with various factors in 24 felid species using data from 213 published articles. Since the frequency of plant occurrence has not always been reported, we created two‐part models and estimated parameters in a Bayesian framework. We found a significant negative relationship between the frequency of plant occurrence and body mass. This may be because plant‐eating behavior reduces the energy loss caused by parasites and increases the efficiency of energy intake, which has a greater importance in smaller animals that have relatively high metabolic rates. This exploratory study highlights the importance of considering plant consumption in dietary studies on carnivorous species to understand the adaptive significance of this behavior and the relationship between obligate carnivores and plants.
Considerations for future environmental DNA accreditation and proficiency testing schemes
Authors: Trujillo‐González Alejandro , Villacorta‐Rath Cecilia , White Nicole E. , Furlan Elise M. , Sykes Mark , Grossel Geoff , Divi Uday K. , Gleeson Dianne 
Published: July 2021

AbstractEnvironmental DNA (eDNA) monitoring has revolutionized the way biodiversity is surveyed and has been proposed as a reliable method to inform management decisions. Recognition of eDNA techniques as reliable tools to inform management and biosecurity require stringent standards to assess sample quality and reliability of results. Laboratories can have their workflows assessed and certified through accreditation and be involved in proficiency testing schemes provided to test the accuracy and precision of molecular methods. Currently, there is only one eDNA‐based proficiency testing scheme designed to test competency of laboratories in amplifying eDNA from the Great Crested Newt, Triturus cristatus (Laurenti, 1768) in water samples. This test, however, is a closed scheme currently run by invitation only to laboratories in the United Kingdom. Given the paucity of eDNA‐based proficiency schemes to ensure high‐quality services, this commentary discusses how future proficiency testing schemes could be designed to assess eDNA sample quality and reliability on detection results for environmental management and biosecurity applications. We discuss the use of tissue‐derived and synthetic oligonucleotides as reference materials, the need for proficiency testing schemes to assess the capacity of analytical facilities to determine sample quality as well as accurately detecting trace eDNA in blind samples and discuss the context in which fit for purpose eDNA testing schemes could be designed. To complement the future development of eDNA proficiency testing schemes, we provide firsthand accounts and lessons learned while developing the current Great Crested Newt eDNA proficiency scheme. Lastly, we highlight current limitations in standardizing rapidly improving eDNA‐based techniques and discuss disadvantages to accreditation and standardization from an Australian‐centered perspective as a means to promote an active debate on the topic of future eDNA accreditation and proficiency testing.
Use of novel non‐invasive techniques and biomarkers to guide outpatient management of fluid overload and reduce hospital readmission: systematic review and meta‐analysis
Authors: Zisis Georgios , Halabi Amera , Huynh Quan , Neil Christopher , Carrington Melinda , Marwick Thomas H. 
Published: July 2021

AbstractAimsFluid congestion is a leading cause of hospital admission, readmission, and mortality in heart failure (HF). We performed a systematic review and meta‐analysis to determine the effectiveness of an advanced fluid management programme (AFMP). The AFMP was defined as an intervention providing tailored diuretic therapy guided by intravascular volume assessment, in hospitalized patients or after discharge. The AFMP group was compared with patients who received standard care treatment. The aim of this systematic review and meta‐analysis was to determine the effectiveness of an AFMP in improving patient outcomes.Methods and resultsA systematic review of randomized controlled trials, case–control studies, and crossover studies using the terms ‘heart failure’, ‘fluid management’, and ‘readmission’ was conducted in PubMed, CINAHL, and Scopus up until November 2020. Studies reporting the association of an AFMP on readmission and/or mortality were included in our meta‐analyses. Risk of bias was assessed in non‐randomized studies using the Newcastle–Ottawa Scale. From 232 retrieved studies, 12 were included in the data synthesis. The 6040 patients in the included studies had a mean age of 72 ± 4 years and mean left ventricular ejection fraction of 39 ± 8%, there were slightly more men (n = 3022) than women, and the follow‐up period was a mean of 4.8 ± 3.1 months. Readmission data were available in 5362 patients; of these, 1629 were readmitted. Mortality data were available in 5787 patients; of these, 584 died. HF patients who had an AFMP in hospital and/or after discharge had lower odds of all‐cause readmission (odds ratio—OR 0.64 [95% confidence interval—CI 0.44, 0.92], P = 0.02) with moderate heterogeneity (I2 = 46.5) and lower odds of all‐cause mortality (OR 0.82 [95% CI 0.69, 0.98], P = 0.03) with low heterogeneity (I2 = 0). The use of an AFMP was equally effective in reducing readmission and mortality regardless of age and follow‐up duration. Effective pre‐discharge diuresis was associated with significantly lower readmission odds (OR 0.43 [95% CI 0.26, 0.71], P = 0.001) compared with a fluid management plan as part of post‐discharge follow‐up.ConclusionsAn effective AFMP is associated with improving readmission and mortality in HF. Our results encourage attainment of optimal volume status at discharge and prescription of optimal diuretic dose. Ongoing support to maintain euvolaemia and effective collaboration between healthcare teams, along with effective patient education and engagement, may help to reduce adverse outcomes in HF patients.
Reflecting on research: Researcher identity in conflict studies from the perspectives of participants
Authors: Uluğ Özden Melis , Acar Yasemin Gülsüm , Kanık Betül 
Published: July 2021

AbstractWhile researchers have long discussed the impact that ingroup–outgroup identities may have on participant–researcher dynamics, no previous study that we know of has investigated how these identities impact participants’ decisions to participate in research in conflict contexts. In this study, we aimed to examine participants’ perspectives on their decisions to participate in research and how those decisions may be related to both their and the researchers’ identities as well as other important dynamics, such as political ideology. We used the Turkish–Kurdish conflict as a case and examined participants’ perspectives on Turkish researchers in this conflict context. More specifically, we investigated (1) opinions and feelings about Turkish researchers; (2) reasons for (not) participating in research by Turkish researchers; (3) the ways Turkish researchers affect participants’ decisions; and (4) attitudes toward Kurdish researchers. We used a survey with open‐ended questions to explore participants’ perspectives and analysed the data from 137 participants who identify as Kurdish using qualitative content analysis. Results highlighted the important opinions and feelings about Turkish researchers such as researchers’ ideological positions, objectivity, and sincerity, as well as how researchers’ other identities may affect participants’ evaluations of their research and how Kurdish researchers are perceived by Kurdish participants. We discuss the ingroup–outgroup dynamics together with other identities in relation to existing identity literature, as well as practical implications of our research for participant recruitment.
Thermodynamic characterization of Mg‐50 wt% LaNi5 composite hydride for thermochemical energy storage application
Authors: Sarath Babu Kaki , Emadabathuni Anil Kumar 
Published: July 2021

AbstractIn the present work, composite material, Mg‐50 wt% LaNi5, is thermodynamically characterized for thermochemical energy storage application, and its mechanism of hydrogen absorption is studied by using Johnson‐Mehl‐Avrami (JMA) equation. Pressure concentration isotherms (PCI) of the composite during hydrogen absorption and desorption are measured at 250°C, 300°C, 350°C, and 375°C. The enthalpy of absorption and enthalpy of desorption are calculated as 62.082 and 66.009 kJ/mol H2. Absorption kinetics is measured at 250°C, 300°C, and 350°C with hydrogen supply pressures of 10, 20, and 30 bar. The activation energies are calculated at different supply pressures using Arrhenius equation. Based on activation energy, the rate‐limiting steps are identified. A thermochemical energy storage method is proposed based on equilibrium pressure‐temperature relation obtained during absorption and desorption. The amount of thermochemical energy stored and recovered per kg of the composite is calculated based on reaction enthalpies and hydrogen concentration. The maximum theoretical thermochemical energy stored and recovered at a temperature of 350°C is calculated as 1452.198 and 1365.804 kJ/kg respectively. The maximum theoretical energy storage efficiency is estimated as 0.94. Hence, the composite, Mg‐50 wt% LaNi5, can be used as thermochemical energy storage material in the temperature range of 250°C‐350°C with a thermochemical energy storage capacity of 0.403 kWh/kg composite.
Modeling the Bioavailability of Nickel and Zinc to Ceriodaphnia dubia and Neocloeon triangulifer in Toxicity Tests with Natural Waters
Authors: Besser John M. , Ivey Chris D. , Steevens Jeffery A. , Cleveland Danielle , Soucek David , Dickinson Amy , Van Genderen Eric J. , Ryan Adam C. , Schlekat Chris E. , Garman Emily , Middleton Ellie , Santore Robert 
Published: July 2021

Abstract
We studied biotic ligand model (BLM) predictions of the toxicity of nickel (Ni) and zinc (Zn) in natural waters from Illinois and Minnesota, USA, which had combinations of pH, hardness, and dissolved organic carbon (DOC) more extreme than 99.7% of waters in a nationwide database. We conducted 7-day chronic tests with Ceriodaphnia dubia and 96-hour acute and 14-day chronic tests with Neocloeon triangulifer and estimated median lethal concentrations and 20% effect concentrations for both species. Toxicity of Ni and Zn to both species differed among test waters by factors from 8 (Zn tests with C. dubia) to 35 (Zn tests with N. triangulifer). For both species and metals, tests with Minnesota waters (low pH and hardness, high DOC) showed lower toxicity than Illinois waters (high pH and high hardness, low DOC). Recalibration of the Ni BLM to be more responsive to pH-related changes improved predictions of Ni toxicity, especially for C. dubia. For the Zn BLM, we compared several input data scenarios, which generally had minor effects on model performance scores (MPS). A scenario that included inputs of modeled dissolved inorganic carbon and measured Al and Fe(III) produced the highest MPS values for tests with both C. dubia and N. triangulifer. Overall, the BLM framework successfully modeled variation in toxicity for both Zn and Ni across wide ranges of water chemistry in tests with both standard and novel test organisms. Environ Toxicol Chem 2021;40:3049–3062. © 2021 SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.