bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cost-effectiveness of government actions to reduce sodium intake through salt substitutes in Vietnam
Authors: Taylor Colman , Hoek Annet C. , Deltetto Irene , Peacock Adrian , Ha Do Thi Phuong , Sieburg Michael , Hoang Dolly , Trieu Kathy , Cobb Laura K. , Jan Stephen , Webster Jacqui 
Published: March 2021

Abstract
Background
Dietary sodium reduction is recommended to reduce the burden of cardiovascular disease. In Vietnam food products including salt, fish sauce and bot canh contribute to ~ 70% of dietary sodium intake. Reduced sodium versions of these products can be produced by replacing some of the sodium chloride with potassium chloride. We aimed to assess the cost-effectiveness of three alternative approaches to introducing reduced sodium products onto the market with a view to lowering population sodium intake in Vietnam.

Methods
The three salt substitution strategies included voluntary, subsidised and regulatory approaches targeting salt, fish sauce and bot canh products. Costs were modelled using the WHO-CHOICE methodology. A Markov cohort model was developed to evaluate the cost-effectiveness of each strategy versus no intervention from the government perspective. The model linked each intervention strategy to assumed changes in levels of sodium intake and then to systolic blood pressure. Changes in SBP were linked to a probability of ischaemic heart disease or stroke. The model followed people over their lifetime to assess average costs and quality adjusted life years (QALYs) gained for each strategy.

Results
The voluntary salt substitution strategy was assumed to require no investment by government. Following ramp up (years 6+), the average annual costs for the subsidised and regulatory strategies were 21,808,968,902 ₫ (US$ 977,354) and 12,949,953,247 ₫ (US$ 580,410) respectively. Relative to no intervention, all three salt substitution strategies were found to be cost-effective. Cost savings were driven by reductions in strokes (32,595; 768,384; 2,366,480) and ischaemic heart disease (IHD) events (22,830; 537,157; 1,648,590) for the voluntary, subsidised & regulatory strategies, respectively. The voluntary strategy was least cost-effective (− 3445 ₫ US$ -0.15; 0.009 QALYs gained) followed by the subsidised strategy (− 43,189 ₫ US$ -1.86; 0.022 QALYs gained) and the regulatory strategy delivered the highest cost savings and health gains (− 243,530 ₫ US$ -10.49; 0.074 QALYs gained).

Conclusion
This research shows that all three modelled salt substitution strategies would be good value for money relative to no intervention in Vietnam. The subsidised alternative would require the highest level of government investment; however the implementation costs will be exceeded by healthcare savings assuming a reasonable time horizon is considered.
Foley catheter with noble metal alloy coating for preventing catheter-associated urinary tract infections: a large, multi-center clinical trial
Authors: Kai-Larsen Ylva , Grass Stefan , Mody Bhaumik , Upadhyay Swati , Trivedi Hargovind L. , Pal Dilip. K. , Babu Santosh , Bawari Bikash , Singh Shrawan. K. 
Published: March 2021

Abstract
Background
Catheter-associated urinary tract infections (CAUTI) are among the most frequent healthcare-associated infections in the world. They are associated with increased mortality, prolonged hospital stay and increased healthcare costs. The objective of this study was to evaluate the efficacy of the noble metal alloy (NMA) coated BIP Foley Catheter in preventing the incidence of symptomatic CAUTI in a large cohort of patients in India.

Methods
This multi-center, prospective study included 1000 adult patients admitted to six hospitals across India for urology, surgery and ICU requiring urethral catheterization and admission for ≥ 48 h. Patients were allocated to the NMA-coated BIP Foley Catheter group or a non-coated control catheter group, with a randomization ratio of 3:1. CAUTI surveillance was conducted at study entry, upon catheter removal, and 2 days after catheter removal. For statistical analysis, categorical data (e.g. gender) were compared using the chi-square or Fischer test, and numerical data were compared using the two-sample t-test. Associations were evaluated using logistic regression.

Results and conclusions
The incidence of symptomatic CAUTI was reduced by 69% in the BIP Foley Catheter group compared to the control group (6.5 vs 20.8 CAUTI/1000 catheter days), with an incidence rate ratio of 0.31 (95% confidence interval: 0.21–0.46; p < 0.001). A reduction in the cumulative CAUTI incidence was evident in the BIP Foley Catheter group within 3 days after catheterization; this reduction was maintained up to ~ 30 days, and the largest reductions were seen between 3 and 11 days. There were no serious adverse events related to either catheter, and the percentage of patients with ≥ 1 adverse event was significantly lower in the NMA-coated BIP Foley Catheter group than in the control group (21.6% vs. 48.4%; p = 0.001). In conclusion, the NMA-coated BIP Foley Catheter was effective in reducing CAUTI and was well tolerated, with a lower incidence of adverse events compared to the uncoated catheter.
Trial registration This study was registered prospectively (28 September 2015) in the Clinical Trials Registry of India (trial number CTRI/2015/09/006220; http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=12631&EncHid=&userName=bactiguard).
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19
Authors:   and the Covid-Clinic-Toul investigators, Lafaurie Margaux , Martin-Blondel Guillaume , Delobel Pierre , Kamar Nassim , Charpentier Sandrine , Sommet Agnès , Moulis Guillaume 
Published: March 2021

Abstract
Background
The impact of prior exposure to systemic corticosteroids on COVID-19 severity in patients hospitalized for a SARS-CoV-2 pneumonia is not known. The present study was designed to answer to this question.

Methods
The population study was the Covid-Clinic-Toul cohort which records data about all hospitalized patients with a positive reverse transcriptase polymerase chain reaction for a SARS-CoV-2 infection at Toulouse University hospital, France. Exposure to systemic corticosteroids was assessed at hospital admission. A propensity score (PS) according to corticosteroid exposure was calculated including comorbidities, clinical, radiological and biological variables that impact COVID-19 severity. The primary outcome was composite, including admission to intensive care unit, need of mechanical ventilation and death occurring during the 14 days after hospital admission. Logistic regression models adjusted for the PS (overlap weighting) provided odds ratios (ORs) and their 95% confidence intervals (95% CIs).

Results
Overall, 253 patients were included in the study. Median age was 64 years, 140 patients (59.6%) were men and 218 (86.2%) had at least one comorbidity. Seventeen patients (6.7%) were exposed to corticosteroids before hospital admission. Chronic inflammatory disease (n = 8) was the most frequent indication. One hundred and twenty patients (47.4%) met the composite outcome. In the crude model, the OR of previous exposure to systemic corticosteroids was 1.64; 95% CI: 0.60–4.44. In the adjusted model, it was 1.09 (95% CI: 0.65–1.83).

Conclusion
Overall, this study provide some evidences for an absence of an increased risk of unfavorable outcome with previous exposure to corticosteroids in the general setting of patients hospitalized for COVID-19.
Data science approach to stock prices forecasting in Indonesia during Covid-19 using Long Short-Term Memory (LSTM)
Authors: Budiharto Widodo 
Published: March 2021

Abstract
Background
Stock market process is full of uncertainty; hence stock prices forecasting very important in finance and business. For stockbrokers, understanding trends and supported by prediction software for forecasting is very important for decision making. This paper proposes a data science model for stock prices forecasting in Indonesian exchange based on the statistical computing based on R language and Long Short-Term Memory (LSTM).

Findings
The first Covid-19 (Coronavirus disease-19) confirmed case in Indonesia is on 2 March 2020. After that, the composite stock price index has plunged 28% since the start of the year and the share prices of cigarette producers and banks in the midst of the corona pandemic reached their lowest value on March 24, 2020. We use the big data from Bank of Central Asia (BCA) and Bank of Mandiri from Indonesia obtained from Yahoo finance. In our experiments, we visualize the data using data science and predict and simulate the important prices called Open, High, Low and Closing (OHLC) with various parameters.

Conclusions
Based on the experiment, data science is very useful for visualization data and our proposed method using Long Short-Term Memory (LSTM) can be used as predictor in short term data with accuracy 94.57% comes from the short term (1 year) with high epoch in training phase rather than using 3 years training data.
Recent advances in electroconvulsive therapy and physical treatments for depression
Authors: Ferrier I. Nicol , Waite Jonathan , Sivasanker Vimal 
Published: March 2021

SUMMARYThis article gives an update for practitioners on recent developments in the use of electroconvulsive therapy (ECT) and related treatment modalities in the contemporary treatment of depression in the UK. Details are provided on new information on the efficacy and side-effects of ECT both in research studies and in the real world, together with recent research on ECT's mode of delivery. There is a focus on the safe administration of ECT in clinical practice. An update on the regulatory framework for ECT in the UK is provided, together with up-to-date information on the legal situation regarding its prescription. Finally, brief summaries of the current position for other neuromodulatory treatment modalities are given.
Container Closure and Delivery Considerations for Intravitreal Drug Administration
Authors: Parenky Ashwin C. , Wadhwa Saurabh , Chen Hunter H. , Bhalla Amardeep S. , Graham Kenneth S. , Shameem Mohammed 
Published: March 2021

AbstractIntravitreal (IVT) administration of therapeutics is the standard of care for treatment of back-of-eye disorders. Although a common procedure performed by retinal specialists, IVT administration is associated with unique challenges related to drug product, device and the procedure, which may result in adverse events. Container closure configuration plays a crucial role in maintaining product stability, safety, and efficacy for the intended shelf-life. Careful design of primary container configuration is also important to accurately deliver small volumes (10-100 μL). Over- or under-dosing may lead to undesired adverse events or lack of efficacy resulting in unpredictable and variable clinical responses. IVT drug products have been traditionally presented in glass vials. However, pre-filled syringes offer a more convenient administration option by reducing the number of steps required for dose preparation there by potentially reducing the time demand on the healthcare providers. In addition to primary container selection, product development studies should focus on, among other things, primary container component characterization, material compatibility with the formulation, formulation stability, fill volume determination, extractables/leachables, and terminal sterilization. Ancillary components such as disposable syringes and needles must be carefully selected, and a detailed administration procedure that includes dosing instructions is required to ensure successful administration of the product. Despite significant efforts in improving the drug product and administration procedures, ocular safety concerns such as endophthalmitis, increased intraocular pressure, and presence of silicone floaters have been reported. A systematic review of available literature on container closure and devices for IVT administration can help guide successful product development.
Accessing Kardar-Parisi-Zhang universality sub-classes with exciton polaritons
(a)
Authors: Deligiannis Konstantinos , Squizzato Davide , Minguzzi Anna , Canet Léonie 
Published: March 2021

Abstract
Exciton-polariton condensates under driven-dissipative conditions are predicted to belong to the Kardar-Parisi-Zhang (KPZ) universality class, the dynamics of the condensate phase at long distance satisfying the same equation as for classical stochastic interface growth. We show that by engineering an external confinement for one-dimensional polaritons we can access two different universality sub-classes, which are associated to the flat or curved geometry for the interface. Our results for the condensate phase distribution and correlations match with great accuracy with the exact theoretical results for KPZ: the Tracy-Widom distributions (GOE and GUE) for the one-point statistics, and covariance of Airy processes (Airy1 and Airy2) for the two-point statistics. This study promotes the exciton-polariton system as a compelling platform to investigate KPZ universal properties.
Model Study toward Total Synthesis of Dimeric Pyranonaphthoquinones: Synthesis of Hemi-Actinorhodin
Authors: Ando Yoshio , Fukazawa Takumi , Ohmori Ken , Suzuki Keisuke 
Published: March 2021

Abstract
In connection with our synthetic study toward the dimeric pyranonaphthoquinone antibiotics, actinorhodin (1) and β-naphthocyclinone (3), we describe herein the synthesis of a monomer, hemi-actinorhodin (6) as a model target. Several implications were gained, including (1) stereoselective synthesis of the pyranonaphthoquinone, (2) viable construction of the naphthazarin core, and (3) the final deprotection conditions.
Providing Time in the Schedule Is Insufficient for Increasing Physical Activity in Childcare
Authors: Willis Erik A. , Hales Derek , Burney Regan , Smith Falon T. , Vaughn Amber E. , Ward Dianne S. 
Published: March 2021

ABSTRACT
The purpose of this study was to describe differences in children’s sedentary behavior and physical activity (PA) when their early care and education center met the recommended PA practices. Up to 4 d of Environment and Policy Assessment and Observation was collected on 80 centers and 150 classrooms along with corresponding accelerometer (ActiGraph GT3X+) data on 472 children. Linear mixed models were used to examine children’s PA outcomes based on compliance with the recommended PA practices (≥60 min·d−1 of outdoor play, ≥120 min·d−1 of indoor/outdoor play, and <60 min·d−1 of sedentary time). Meeting outdoor play recommendation was associated with a significant difference in centers’ time use: +56.7 min·d−1 of outdoor play and −38.5 min·d−1 of indoor play, resulting in an approximately 9 min·d−1 increase in children’s total PA while at childcare. Meeting indoor/outdoor play recommendation was associated with differences in centers’ time use: +66.9 min·d−1 of indoor/outdoor play, −29.7 min·d−1 of screen/sitting, −11.4 min·d−1 for circle time, and −19.2 min·d−1 of nonclassified activities, resulting in an approximately 14 min·d−1 increase in children’s total PA while at childcare. Meeting recommendation for limiting sedentary time was associated with −55.0 min·d−1 of screen/sitting, +24.4 min·d−1 of indoor play, +15.1 min·d−1 of outdoor play, and +8.4 min·d−1 for circle time, resulting in an approximately 7.0 min·d−1 increase in children’s light activity only while at childcare. Classroom compliance with the recommended practices at childcare had minimal association with children’s total daily or at home PA levels. These results suggest that providing time for play alone leads to minimal increases in total PA. These findings suggest the need for more quality play opportunities (e.g., provider-led PA) rather than allocating time alone to improve daily PA.
Future scenarios for the SARS-CoV-2 epidemic in Switzerland: an age-structured model
Authors: Estill Janne , Venkova-Marchevska Plamenna , Roelens Maroussia , Orel Erol , Temerev Alexander , Flahault Antoine , Keiser Olivia 
Published: March 2021

The recent lifting of COVID-19 related restrictions in Switzerland causes uncertainty about the future of the epidemic. We developed a compartmental model for SARS-CoV-2 transmission in Switzerland and projected the course of the epidemic until the end of year 2020 under various scenarios. The model was age-structured with three categories: children (0-17), adults (18-64) and seniors (65- years). Lifting all restrictions according to the plans disclosed by the Swiss federal authorities by mid-May resulted in a rapid rebound in the epidemic, with the peak expected in July. Measures equivalent to at least 76% reduction in all contacts were able to eradicate the epidemic; a 54% reduction in contacts could keep the intensive care unit occupancy under the critical level and delay the next wave until October. In scenarios where strong contact reductions were only applied in selected age groups, the epidemic could not be suppressed, resulting in an increased risk of a rebound in July, and another stronger wave in September. Future interventions need to cover all age groups to keep the SARS-CoV-2 epidemic under control.
Genome-wide regulation of CpG methylation by ecCEBPα in acute myeloid leukemia
Authors: Ogunleye Adewale J. , Romanova Ekaterina , Medvedeva Yulia A. 
Published: March 2021

Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by genetic and epigenetic aberrations that alter the differentiation capacity of myeloid progenitor cells. The transcription factor CEBPα is frequently mutated in AML patients leading to an increase in DNA methylation in many genomic locations. Previously, it has been shown that ecCEBPα (extra coding CEBPα) - a lncRNA transcribed in the same direction as CEBPα gene - regulates DNA methylation of CEBPα promoter in cis. Here, we hypothesize that ecCEBPα could participate in the regulation of DNA methylation in trans. Method: First, we retrieved the methylation profile of AML patients with mutated CEBPα locus from The Cancer Genome Atlas (TCGA). We then predicted the ecCEBPα secondary structure in order to check the potential of ecCEBPα to form triplexes around CpG loci and checked if triplex formation influenced CpG methylation, genome-wide. Results: Using DNA methylation profiles of AML patients with a mutated CEBPα locus, we show that ecCEBPα could interact with DNA by forming DNA:RNA triple helices and protect regions near its binding sites from global DNA methylation. Further analysis revealed that triplex-forming oligonucleotides in ecCEBPα are structurally unpaired supporting the DNA-binding potential of these regions. ecCEBPα triplexes supported with the RNA-chromatin co-localization data are located in the promoters of leukemia-linked transcriptional factors such as MLF2. Discussion: Overall, these results suggest a novel regulatory mechanism for ecCEBPα as a genome-wide epigenetic modulator through triple-helix formation which may provide a foundation for sequence-specific engineering of RNA for regulating methylation of specific genes.
Employee Adaptation As an Essential Element of Human Resource Management in a Production Organization
Authors: Petrenko B. 
Published: March 2021

The article analyzes the features of adaptation of an employee of a production organization as a process of adaptation of a young specialist ("novice") to the changing conditions of the workplace, as well as the labor collective to a new employee and to changes in the internal and external environment of the organization.
The specifics and differences between adaptation and probation period as the main period of the process of adaptation of a new employee to the organization are determined.
Focuses on the revival of mentoring, in which the education of the "newbie" is performed by attaching officials and (or) the most trained workers - "mentors" responsible for the development of professional qualities of the appointed employee. The experience of adaptation in power structures is analyzed.
Sequência Fedathi para mudança de prática: estudo de caso de uma experiência com o teatro científico
Authors: Felício Milinia Stephanie Nogueira Barbosa , Menezes Daniel Brandão , Borges Neto Hermínio 
Published: March 2021

É preciso estar disposto a mudanças, a fim de ressignificar práticas educativas. O artigo investiga, por meio de estudo de caso, como a Sequência Fedathi pode transformar práticas docentes. Para tanto, observa-se os resultados relatados nas impressões da docente e dos alunos envolvidos, diretamente, com a experiência do teatro científico, realizado em uma escola estadual de Fortaleza. Reflete-se ainda sobre o impacto desse processo nas mediações. A pesquisa é qualitativa, utiliza-se também a pesquisa participante e a metodologia de pesquisa Sequência Fedathi. As metodologias de pesquisa e ensino Sequência Fedathi fazem parte do planejamento e da vivência da prática da professora. A mudança de prática do professor não é apenas uma nova técnica utilizada, o teatro, trata-se de uma forma diferente de fazer, com uma metodologia atrelada e com um objetivo consistente. Recomenda-se, ainda, uma proposta continuada de formação docente a fim de reconstruir concepções de ensino e aprendizagem, que aliem técnicas de ensino a uma metodologia transformadora.
Bridging the skills gap: apprentice assistant practitioners having an impact in mental healthcare services. Part 3. The mentor experience
Authors: Morris Andy , Higginson Helen 
Published: March 2021

Understanding the relevance of the apprentice assistant practitioner (AAP) role in mental health is important for future developments within mental health services. This third article, in a series of four exploring the potential impact of AAPs in bridging the gap in mental health services, focuses on the experiences of the mentor role.Mentorship in the development of health service workers is crucial to ensure competent, confident and skilled staff at all levels. This small-scale study looks at the experiences of the mentor in general and more specifically the experiences of a small group of mentors supporting AAPs in mental health services.A questionnaire was sent to mentors at different stages of the AAP's journey and asked them to consider three broad themes: supporting the AAP, helpfulness of the AAP standards in mentoring; and the impact of the AAP in mental health services.The results show a positive response in general from the mentors and the use of apprenticeship standards to focus the mentorship of the AAP, as well as the potential benefits the assistant practitioner (AP) role has in both supporting services users and the service as a whole.