bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed Tomography Coronary Angiography Possibilities in “High Risk” Plaque Identification in Patients with non-ST-Elevation Acute Coronary Syndrome: Comparison with Intravascular Ultrasound
Authors: Merkulova I. N. , Shariya M. A. , Mironov V. M. , Shabanova M. S. , Veselova T. N. , Gaman S. A. , Barysheva N. A. , Shakhnovich R. M. , Zhukova N. I. , Sukhinina T. S. , Staroverov I. I. , Ternovoy S. K. 
Published: February 2021

Aim To evaluate structural characteristics of atherosclerotic plaques (ASP) by coronary computed tomography arteriography (CCTA) and intravascular ultrasound (IVUS).Material and methods This study included 37 patients with acute coronary syndrome (ACS). 64-detector-row CCTA, coronarography, and grayscale IVUS were performed prior to coronary stenting. The ASP length and burden, remodeling index (RI), and known CT signs of unstable ASP (presence of dot calcification, positive remodeling of the artery in the ASP area, irregular plaque contour, presence of a peripheral high-density ring and a low-density patch in the ASP). The ASP type and signs of rupture or thrombosis were determined by IVUS.Results The IVUS study revealed 45 unstable ASP (UASP), including 25 UASP with rupture and 20 thin-cap fibroatheromas (TCFA), and 13 stable ASP (SASP). No significant differences were found between distribution of TCFA and ASP with rupture among symptom-associated plaques (SAP, n=28) and non-symptom-associated plaques (NSAP, n=30). They were found in 82.1 and 73.3 % of cases, respectively (p>0.05), which indicated generalization of the ASP destabilization process in the coronary circulation. However, the incidence of mural thrombus was higher for SAP (53.5 and 16.6 % of ASP, respectively; p<0.001). There was no difference between UASP and SASP in the incidence of qualitative ASP characteristics or in values of quantitative ASP characteristics, including known signs of instability, except for the irregular contour, which was observed in 92.9 % of UASP and 46.1 % of SASP (p=0.0007), and patches with X-ray density ≤46 HU, which were detected in 83.3 % of UASP and 46.1 % of SASP (р=0.01). The presence of these CT criteria 11- and 7-fold increased the likelihood of unstable ASP (odd ratio (OR), 11.1 at 95 % confidence interval (CI), from 2.24 to 55.33 and OR, 7.0 at 95 % CI, from 5.63 to 8.37 for the former and the latter criterion, respectively).Conclusion According to IVUS data, two X-ray signs are most characteristic for UASP, the irregular contour and a patch with X-ray density ≤46 HU. The presence of these signs 11- and 7-fold, respectively, increases the likelihood of unstable ASP.
ABC frente a las huelgas generales en la época socialista en España, 1985-1994: imaginario, tópicos, prejuicios de clase e información periodística
Authors: Gálvez Biesca Sergio 
Published: February 2021

El presente artículo propone un estudio de caso inédito, en torno a la estrategia y la línea editorial del ABC frente a las huelgas generales convocadas por las principales centrales sindicales durante la primera época socialista en España (1982-1996). Dentro de este marco contextual, se examinan las potencialidades y las dificultades de emplear los medios de comunicación como fuentes históricas, a través de las cuales se puede leer un contexto, ubicar series y, entre otras, conocer expresiones de la sociedad en un momento determinado. Por último, el texto cuestiona determinadas ideas-fuerzas sobre el supuesto carácter de medio riguroso y serio del ABC, como expresión social la presa está cargada de parámetros ideológicos, identiarios, que pueden leerse en los editoriales, que para el caso que nos ocupa refleja los intereses de las éliteseconómicas españolas.
Asentamiento indígena de Hunza anterior a la conquista. Una mirada desde los imaginarios
Authors: Portilla Tarazona Jairo Arturo 
Published: February 2021

El objetivo de esta investigación fue establecer cómo la comunidad indígena de Hunza mantenía en el siglo XVI, a la llegada de los españoles, algunos centros ceremoniales y simbólicos como proceso natural y cultural que hicieron parte de sus imaginarios e identidades colectivas. Al respecto, se abordó el estudio del espacio geográfico del asentamiento de Hunza, de acuerdo con las características físicas del paisaje y su relieve, así mismo, se establecieron relaciones entre el espacio geográfico y los imaginarios construidos por sus habitantes, que son expresión de su cosmogonía.
State of the art on critical environmental education at the Research Meeting on Environmental Education
Authors: Silveira Dieison Prestes da , Lorenzetti Leonir 
Published: February 2021

Critical environmental education [CEE] is presented as an important form of social intervention, since it helps in the promotion and understanding of socio-environmental problems in their multiple dimensions. Thus, in this article, the research on CEE, presented at the Research Meeting on Environmental Education [RMEE], in the time period between 2001 and 2019, was analyzed, taking into account its possibilities as a means of scientific communication, since it allows the debate about environmental education and its connections in the contemporary world. The methodology was based on a state-of-the-art research. 898 works were found in the archives of the RMEE. Forty-one papers with the term critical environmental education in their title were analyzed. For the analysis, descriptors and categories were created. Discursive textual analysis was adopted to interpret the data. In 2017 and 2015, there was the largest number of publications of works related to CEE. It is observed that CEE enables a new perspective on issues related to nature and society, as well as on emerging situations in the contemporary world, through the reflection on the quality of life and actions related to nature and society.
Aproximación histórica a los inicios del boxeo femenino y las circunstancias del surgimiento del deporte olímpico de las mujeres = Historical approach to the beginnings of women's boxing and the circumstances of the appearance of women's Olympic sport
Authors: Martínez-Gorroño Mª Eugenia , Calle-Molina María Teresa 
Published: February 2021

El inicio del boxeo femenino y su primer combate dentro de los eventos que constituyeron los Juegos de San Luis de 1904 se produjo a pesar de no contar con el beneplácito ni de Coubertin ni de otros sectores sociales médicos, que argumentaban los problemas de salud que los esfuerzos físicos excesivos podían implicar para las mujeres. Por otra parte, ciertos sectores del “cuarto poder” que ya comenzaba a ser la prensa, encontraban en las competiciones deportivas femeninas una fuente de titulares expuestos como esperpénticos para conseguir aumentar sus lectores. Era una oportunidad de ridiculizar y utilizar de mofa a las pocas deportistas que osaban iniciarse. Aquellos aspectos, al igual que los condicionantes relativos al rol social de las mujeres, determinaron un posicionamiento del Comité Olímpico Internacional que se prolongó durante un siglo, influyendo decisivamente en laincorporación tan tardía que la práctica del boxeo femenino ha experimentado en las estructuras deportivas. La evolución de los criterios del Movimiento Olímpico actual, al respecto del deporte de lasmujeres ha sido definitiva a partir de la labor de Juan Antonio Samaranch. AbstractThe beginning of feminine boxing and its first combat within the events that constituted the 1904 San Luis Games took place in spite of not having the approval of either Coubertin or other medical social sectors, who argued the health problems that excessive physical efforts could imply for women. On the other hand, certain sectors of the "fourth estate", which was already beginning to be the press, found inwomen's sports competitions a source of headlines that were exposed as bizarre in order to increase their readership. It was an opportunity to ridicule and make fun of the few athletes who dared to start. Those aspects, as well as the conditioning factors related to the social role of women, determined a position of the International Olympic Committee that lasted for a century, decisively influencing the late incorporation of the practice of female boxing into sports structures. The evolution of the criteria of the current Olympic Movement, with respect to women's sport, has been definitive since the work of Juan Antonio Samaranch.
Reviewing Cyclonic Low-Shear Choke and Control Valve Field Experiences
Authors: Husveg T. , Husveg R. , van Teeffelen N. , Verwey R. , Guinee P. 
Published: February 2021

Summary
In hydrocarbon production and processing, choke and control valves mix and emulsify petroleum phases. The consequence is often that the efficiency of separation processes is affected and finally that the quality of oil and water phases is degraded. Over the last few years, low-shear valves targeting petroleum processes have emerged on the market.
This paper presents four separate live-fluid experiences from low-shear valve installations, each surveyed and documented by an independent third party. Three of the installations refer to choke valves, whereas the fourth installation refers to a control valve. For each installation, standard choke and control valves were used as reference valves. In terms of downstream separation efficiency, the low-shear choke valves reduced oil-in-water concentrations respectively by 70, 45, and 60%, by total average. In the control valve application, the low-shear valve, which was located between the hydrocyclones and a compact flotation unit, reduced the oil-in-water concentration by 23%.
In sum, the field installations have demonstrated that low-shear valves significantly and consistently reduce oil-in-water concentrations and thus improve the produced water quality. The results signify that low-shear valves may be used in debottlenecking separation and produced water treatment processes, reducing the environmental influence from produced water discharges. Because the low-shear technology enables processing of petroleum phases with less effort, energy, and chemicals, it also reduces emissions to air.
Kinetic comparative study on Aerodynamic Characteristics of Hypersonic Reentry Vehicle from Near-continuous Flow to Free Molecular Flow
Authors: Li Jin , Jiang Dingwu , Geng Xiangren , Chen Jianqiang 
Published: February 2021

Abstract
A scaled model of the X38-like configuration was simulated under hypersonic conditions by the direct simulation Monte Carlo method and the unified gas kinetic scheme. The inflow conditions considered several different flow regimes, from the near-continuum though the slip-transitional to the free molecule regime. Flow fields and surface properties were compared in details between two methods. Not only the density and temperature contours distribution but also the surface pressure, heat flux, friction distribution, both kinetic methods give fairly consistent results. Aerodynamics of the model under hypersonic rarefied conditions were also obtained and compared. The results given by both methods agreed with each other very well. The effects of the Knudsen number and angle of attack were assessed. At the absence of experimental results, it is meaningful to carry out comparative studies and accelerate both methods to further progress.
Enhanced Lipid Metabolism Induces the Sensitivity of Dormant Cancer Cells to 5-aminolevulinic acid-based Photodynamic Therapy
Authors: Nakayama Taku , Sano Tomonori , Oshimo Yoshiki , Kawada Chiaki , Kasai Moe , Yamamoto Shinkuro , Fukuhara Hideo , Inoue Keiji , Ogura Shun-ichiro 
Published: February 2021

Abstract
Cancer can develop into a recurrent metastatic disease with latency periods of years to decades. Dormant cancer cells, which represent a major cause of recurrent cancer, are relatively insensitive to most chemotherapeutic drugs and radiation. We previously demonstrated that cancer cells exhibited dormancy in a cell density-dependent manner. Dormant cancer cells exhibited increased porphyrin metabolism and sensitivity to 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT). However, the metabolic changes in dormant cancer cells or the factors that enhance porphyrin metabolism have not been fully clarified. In this study, we revealed that lipid metabolism was increased in dormant cancer cells, leading to ALA-PDT sensitivity. We performed microarray analysis in non-dormant and dormant cancer cells and revealed that lipid metabolism was remarkably enhanced in dormant cancer cells. In addition, triacsin C, a potent inhibitor of acyl-CoA synthetases (ACSs), reduced protoporphyrin IX (PpIX) accumulation and decreased ALA-PDT sensitivity. We demonstrated that lipid metabolism including ACS expression was positively associated with PpIX accumulation. This research suggested that the enhancement of lipid metabolism in cancer cells induces PpIX accumulation and ALA-PDT sensitivity.
A Collaborative Clinical Case Conference Model for Teaching Social and Behavioral Science in Medicine: An Action Research Study
Authors: Miyachi Junichiro , Iida Junko , Shimazono Yosuke , Nishigori Hiroshi 
Published: February 2021

Abstract
Background: Effective social and behavioral sciences teaching in medical education requires integration with clinical experience, as well as collaboration with social and behavioral sciences experts and clinical faculties. However, teaching models for achieving this integration have not been adequately established, nor has the collaboration process been described. This study aims to propose a collaborative clinical case conference model to integrate social and behavioral sciences and clinical experience. Additionally, we describe how social and behavioral science experts and clinical faculties collaborate during the development of the teaching method.Methods: A team of clinical teachers and medical anthropologists planned for the development of a case conference based on action research methodology. The initial model planned for a 3-hour session, similar to the Clinicopathological Conference structure. We evaluated each session based on fieldnotes taken by medical anthropologists, and post-session questionnaires that surveyed participants’ reactions and points of improvements. Based on the evaluation, a reflective meeting was held to discuss revisions for the next trial. We incorporated the development process into undergraduate medical curricula in clinical years and in a postgraduate and continuous professional development session for residents and certified family physicians in Japan. We repeated the plan-act-observe-reflection process more than 15 times between 2015 and 2018.Results: The development of the collaborative clinical case conference model is summarized in three phases: Quasi-CPC, Interactive, and Co-constructive with unique structures and underlying paradigms. The model successfully contributed to promoting the participants’ recognition of the clinical significance of social and behavioral sciences. The case preparation entailed a unique, significant learning of how social and behavioral sciences inform clinical practice. The model development process promoted the mutual understanding between clinical faculties and anthropologists, which might function as faculty development for teachers involved in social and behavioral sciences teaching in medical education. Conclusions: The application of fitting conference models and awareness of their underlying paradigm according to educational situations could promote the integration of social and behavioral sciences with clinical medicine education. Faculty development in social and behavioral sciences in medical education should focus on collaboration with scholars with different paradigmatic orientations.
Do We Need Fluid Restriction After Stapled Hemorrhoidopexy? A Pilot, Double-Blinded, Randomized Controlled Trial
Authors: Tsai Nien-Ying , Jao Shu-Wen , Chen Chao-Yang , Wen Chia-Cheng , Kao Chien-Chang , Lin Kuan-Ling , Wu Po-Hsien , Yu Chun-Wei , Cheng Yi-Chiao 
Published: February 2021

Abstract
Background: Conventional hemorrhoidectomy leads to a high urinary retention rate and fluid restriction is commonly recommended to minimize complications. However, the need for postoperative fluid restriction among patients who have undergone stapled hemorrhoidopexy is unclear. We aimed to determine whether fluid restriction after stapled hemorrhoidopexy with/without partial external hemorrhoidectomy could reduce urinary retention and postoperative pain.Patients And Methods: In this prospective, double-blinded, randomized controlled trial, we enrolled patients who had grade III or IV hemorrhoids and underwent stapled hemorrhoidopexy with/without partial external hemorrhoidectomy; 250 mL/12 h of sterile 0.9% saline was administered to the fluid restriction group after the operation, and 1000 mL/12 h was given to the non-fluid-restriction group. We focused on the need for fluid restriction after stapled hemorrhoidopexy.Results: Fifty patients were studied in two groups. The surgical outcomes of the two groups were no different. The median subjective pain scores at 0, 8, 16, 24 h after the operation showed no significant difference between the two groups (p = 0.55 at 0 h; p = 0.38 at 8 h; p = 0.98 at 16 h; and p = 0.66 at 24 h). The mean times to first urination after the operation were 700.04 ± 455.03 min in the non-fluid-restriction group and 737.16 ± 426.32 min in the fluid-restriction group (no significant difference; p = 0.67). No postoperative urinary retention was found in either group of patients.Conclusions: Fluid restriction after stapled hemorrhoidopexy is unnecessary.Trial registration: This study was reviewed and approved by the Tri-Service General Hospital Institutional Review Board for human subjects (No. 2-106-05-063). This study also had trial registration with clinicalTrials.gov (Identifier: NCT04459039).
Patient-derived Tumor Xenograft and Organoid Models Established from Resected Pancreatic, Duodenal and Biliary Cancers
Authors: Pham Nhu-An , Radulovich Nikolina , Ibrahimov Emin , Martins-Filho Sebastiao , Li Quan , Pintilie Melania , Weiss Jessica , Raghavan Vibha , Cabanero Michael , Denroche Robert , Wilson Julie M. , Metran-Nascente Cristiane , Borgida Ayelet , Hutchinson Shawn , Dodd Anna , Begora Michael , Chadwick Dianne , Serra Stefano , Knox Jennifer , Gallinger Steven , Hedley David W. , Muthuswamy Lakshmi , Tsao Ming-Sound 
Published: February 2021

Abstract
Patient-derived xenograft (PDX) and their xenograft-derived organoid (XDO) models that recapitulate the genotypic and phenotypic landscape of patient cancers could help to advance research and lead to improved clinical management. PDX models were established from 276 pancreato-duodenal and biliary cancer resections. Initial, passage 0 (P0) engraftment rates were 59% (118/199) for pancreatic, 86% (25/29) for duodenal, and 37% (17/48) for biliary ductal tumors. Pancreatic ductal adenocarcinoma (PDAC), had a P0 engraftment rate of 62% (105/169). KRAS mutant and wild-type PDAC models were molecularly profiled, and XDO models were generated to perform initial drug response evaluations. Subsets of PDAC PDX models showed global copy number variants and gene expression profiles that were retained with serial passaging, and they showed a spectrum of somatic mutations represented in patient tumors. PDAC XDO models were established, with a success rate of 71% (10/14). Pathway activation of KRAS-MAPK in PDXs was independent of KRAS mutational status. Four wild-type KRAS models were characterized by one with EGFR (L747-P753 del), two with BRAF alterations (N486_P490del or V600E), and one with triple negative KRAS/EGFR/BRAF. Model OCIP256, characterized by BRAF (N486-P490 del), had activated phospho-ERK, which was effectively suppressed when using a combination of a pan-RAF inhibitor (LY3009120) and a MEK inhibitor (trametinib), and showed significant inhibition of growth in its XDO and corresponding PDX models. In conclusion, PDAC/duodenal adenocarcinoma have high success rates forming PDX/organoid and retain their phenotypic and genotypic features. These models may be effective tools to evaluate novel drug combinations therapies.
Short-Term Survival and Safety of Apatinib Combined With Oxaliplatin and S-1 in the Conversion Therapy of Unresectable Gastric Cancer
Authors: Ye Zaisheng , Zeng Yi , Wei Shenghong , Wang Yi , Lin Zhitao , Chen Shu , Wang Zhiwei , Chen Shanshan , Chen Luchuan 
Published: February 2021

Abstract
BackgroundTo investigate the short-term efficacy and safety of apatinib combined with oxaliplatin and S-1 in the treatment of unresectable gastric cancer.Patients and methodsPreviously untreated patients with unresectable HER-2-negative advanced gastric cancer were selected. All the patients received six cycles of S-1 and oxaliplatin and five cycles of apatinib, which were administered at intervals of three weeks. The surgery was performed after six cycles of drug treatment. The primary endpoints were radical resection (R0) rate and safety. This study was registered with the China Trial Register, number ChiCTR-ONC-17010430(01/12/2016-01/12/2022).ResultsA total of 39 patients were enrolled. Efficacy evaluation was feasible for 37 patients. One patient achieved complete response (CR, 2.7%), 26 patients achieved partial response (PR, 70.3%), three patients had stable disease (SD, 8.1%) and seven patients had progressive disease (PD, 18.9%). The objective response rate (ORR) was 73.0% and the disease control rate (DCR) was 81.1%. 22 patients underwent surgery, among which 14 patients underwent radical resection (R0), with a R0 resection rate of 63.6%. The 1-year survival rate of the surgical group (22 patients) was 71.1% and the 2-year survival rate was 41.1%. The median survival time was 21 months. The incidence of adverse reactions (AEs) was 100%. Leucopenia (65.3%) and granulocytopenia (69.2%) were the most common hematological AEs. The most common non-hematological AEs were fatigue (51.3%) and oral mucositis (35.9%).ConclusionApatinib combined with oxaliplatin and S-1 showed good short-term survival and acceptable safety in the conversion therapy of unresectable gastric cancer.
Improved Chondrogenic Performance With Protective Tracheal Design of Chitosan Membrane Surrounding 3D-Printed Trachea
Authors: Kim Hyeonji , Lee Jae Yeon , Han Hyeonseok , Cho Won-Woo , Han Hohyeon , Kim Jae Yun , Park Jeong Hun , Park Sun Hwa , Kim Sung Won , Kim Dong Sung , Cho Dong-Woo 
Published: February 2021

Abstract
In recent tracheal tissue engineering, limitations in cartilage reconstruction, caused by immature delivery of chondrocyte-laden components, have been reported beyond the complete epithelialization and integration of the tracheal substitutes with the host tissue. In an attempt to overcome such limitations, this article introduces a protective design of tissue-engineered trachea (TraCHIM) composed of a chitosan-based nanofiber membrane (CHIM) and a 3D-printed biotracheal construct. The CHIM was created from chitosan and polycaprolactone (PCL) using an electrospinning process. Upon addition of chitosan to PCL, the diameter of electrospun fibers became thinner, allowing them to be stacked more closely, thereby improving its mechanical properties. Chitosan also enhances the hydrophilicity of the membranes, preventing them from slipping and delaminating over the cell-laden bioink of the biotracheal graft, as well as protecting the construct. Two weeks after implantation in Sprague-Dawley male rats, the group with the TraCHIM exhibited a higher number of chondrocytes, with enhanced chondrogenic performance, than the control group without the membrane. This study successfully demonstrates enhanced chondrogenic performance of TraCHIM in vivo. The protective design of TraCHIM opens a new avenue in engineered tissue research, which requires faster tissue formation from 3D biodegradable materials, to achieve complete replacement of diseased tissue.