bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity of Personalized Dendritic-cell Therapy in HIV-1 Infected Individuals Under Suppressive Antiretroviral Treatment: Interim Analysis From a Phase II Clinical Trial.
Authors: Batista Marcela Vassão de Almeida , Silva Laís Teodoro , Samer Sadia , Oshiro Telma Miyuki , Shytaj Iart Luca , Giron Leila , Pena Nathalia Mantovani , Cruz Nicolly , Gosuen Gisele Cristina , Ferreira Paulo Roberto Abrão , Neto Edécio Cunha , Galinskas Juliana , Dias Danilo , Sucupira Maria Cecilia Araripe , Almeida-Neto Cesar , Salomão Reinaldo , Duarte Alberto José da Silva , Janini Luís Mário , Hunter James R , Savarino Andrea , Juliano Maria Aparecida , Diaz Ricardo Sobhie 
Published: September 2021

Abstract
BackgroundWe developed a personalized Monocyte-Derived Dendritic Therapy (MDDCT) for HIV-infected individuals on suppressive antiretroviral treatment and evaluated HIV-specific T-cell responses.MethodsPBMCs were obtained from 10 HIV+ individuals enrolled in trial NCT02961829. Monocytes were differentiated into DCs using IFN-α and GM-CSF. After sequencing each patient’s HIV-1 Gag and determining HLA profiles, autologous Gag peptides were selected based on the predicted individual immunogenicity and used to pulse MDDCs. Three doses of the MDDCT were administered every 15 days. To assess immunogenicity, patients’ cells were stimulated in vitro with autologous peptides, and intracellular IL-2, TNF, and interferon-gamma (IFN-γ) production were measured in CD4+ and CD8+ T-cells. ResultsThe protocol of ex-vivo treatment with IFN-α and GM-CSF was able to induce maturation of MDDCs, as well as to preserve their viability for reinfusion. MDDCT administration was associated with increased expression of IL-2 in CD4+ and CD8+ T-cells at 15 and/or 30 days after the first MDDCT administration. Moreover, intracellular TNF and IFN-γ expression was significantly increased in CD4+ T-cells. The number of candidates that increased in vitro the cytokine levels in CD4+ and CD8+ T cells upon stimulation with Gag peptides from baseline to days 15 and from baseline to days 30 and days 120 after MDDCT was significant as compared to Gag unstimulated response. This was accompanied by an increasing trend in the frequency of polyfunctional T-cells over time, which was visible when considering both cells expressing two and three out of the three cytokines examined. ConclusionsMDDC has a mature profile, and this MDDCT promoted in-vitro T-cell immune responses in HIV-infected patients undergoing long-term suppressive antiretroviral treatment.NCT02961829: (Multi Interventional Study Exploring HIV-1 Residual Replication: a Step Towards HIV-1 Eradication and Sterilizing Cure, https://www.clinicaltrials.gov/ct2/show/NCT02961829, posted November 11th, 2016).
A Scoping Review Examining the Integration of Exercise Services in Clinical Oncology Settings
Authors: Ezenwankwo Elochukwu F. , Nnate Daniel A. , Usoro Godspower D. , Onyeso Chimdimma P. , Anieto Ijeoma B. , Ibeneme Sam C. , Albertus Yumna , Lambert Victoria E , Ezeukwu Antoninus O. , Abaraogu Ukachukwu O. , Shamley Delva 
Published: September 2021

Abstract
Background: Addressing questions surrounding the feasibility of embedding exercise service units in clinical oncology settings is imperative for developing a sustainable exercise-oncology clinical pathway. We examined available literature and provided practical recommendations to inform evidence-based practice, policymaking, and further investigations. Methods: Studies that recruited cancer patients, assessed the co-location of exercise services and cancer treatment units and reported findings on service implementation were included. Evidence from six studies providing data from over 30 programs was integrated using narrative synthesis. Results: Exercise service implementation was relatively modest across the included studies. These services were delivered by physiotherapists, exercise physiologists, and kinesiologists and funded mainly through grants and private donations, with staff salaries accruing as the major expense. Service penetration, adoption, and acceptability were generally low. However, studies recorded high clinician/patient satisfaction. Major barriers to service integration were limited funding, lack of detailed implementation plan, and low organizational buy-in. Common reasons for non-utilization, missed sessions, and dropouts were lack of interest, unwellness, hospital readmission, disease progression, and adverse skeletal events. Conclusion: Implementing exercise services in clinical oncology settings seems an effective approach for increasing access to exercise medicine for individuals on cancer treatment. While this model appears feasible for patients/clinicians, calculated efforts are required to drive uptake. There is no one-size-fits-all approach; hence, sustainable service integration remains a product of many factors, including structures and strategies that reflect the organizational dynamics of the clinical service environment housing the exercise unit.
Evolution of the geological structure and mechanical properties due to the collision of multiple basement topographic highs in a forearc accretionary wedge: Insights from numerical simulations
Authors: Miyakawa Ayumu , Noda Atsushi , Koge Hiroaki 
Published: September 2021

Abstract
We propose a conceptual geological model for the collision of multiple basement topographic highs (BTHs; e.g., seamounts, ridges, and horsts) with a forearc accretionary wedge. Even though there are many BTHs on an oceanic plate, there are few examples of modeling the collision of multiple BTHs. We conducted numerical simulations using the discrete element method to examine the effects of three BTH collisions with forearcs. The typical geological structure associated with a BTH collision was reproduced during the collision of the first BTH, and multiple BTH collisions create a cycle of formation of BTH collisional structures. Each BTH forces the basal décollement to move up to the roof décollement, and the roof décollement becomes inactive after the passage of the BTH, and then the décollement moves down to the base. As the active décollement position changes, the sequences of underthrust sediments and uplifted imbricate thrusts are sandwiched between the décollements and incorporated into the wedge. At a low horizontal compressive stress, a “shadow zone” is formed behind (i.e., seaward of) the BTH. When the next BTH collides, the horizontal compressive stress increases and tectonic compaction progresses, which reduce the porosity in the underthrust sediments. Heterogeneous evolution of the geological and porosity structure can generate a distinctive pore pressure pattern. The underthrust sediments retain fluid in the “shadow” of the BTH. Under the strong horizontal compressive stresses associated with the next BTH collision, pore pressure increases along with a rapid reduction of porosity in the underthrust sediments. The distinctive structural features observed in our model are comparable to the large faults in the Kumano transect of the Nankai Trough, Japan, where a splay fault branches from the plate boundary and there are old and active décollements. A low-velocity and high-pore-pressure zone are located at the bottom of the accretionary wedge and in front (i.e., landward) of the subducting ridge in the Kumano transect. This suggests that strong horizontal compressive stresses associated with the current BTH collision has increased the pore pressure within the underthrust sediments associated with previous BTHs.
Resveratrol Nanocrystal Loaded Orodispersible Films: Formulation Development and In Vitro Characterization
Authors: Ozdemir Samet , Uner Burcu , Karakucuk Alptug 
Published: September 2021

Abstract
Nanocrystals are a feasible system to improve the aqueous solubility of poorly soluble compounds. Orodispersible films (ODFs) offer a rapid release of the drug in the mouth and are preferred for patients with dysphagia or paediatrics. The objective of the current study was to develop resveratrol (RES) nanocrystal-loaded ODFs. RES nanocrystals were prepared by antisolvent precipitation in the existence of Poloxamer 188 as a polymeric stabilizer. Polyvinyl alcohol was used for the preparation of the ODFs by using the solvent casting method. Then, RES nanocrystals were incorporated into the films. Particle size (PS), polydispersity index (PDI), and zeta potential (ZP) values were measured for nanocrystals. ODFs were characterized, and bioadhesion, disintegration, and in vitro release studies were performed. RES nanocrystals were obtained with 631 nm PS, 0.314 PDI and − 14.3 ZP values. Over 90% of RES nanocrystals were loaded in ODFs, which were approximately 75 µm in thickness. The thermal and crystal properties of nanocrystals in ODFs were preserved regarding DSC and FTIR analyses. Homogenous distribution in smooth films was observed on SEM. Mechanical properties and bioadhesion forces were found to be appropriate for ODFs. The disintegration time was found below 30 seconds for nanocrystal loaded films. RES nanocrystal loaded film formulations showed > 85% release in 5 minutes, significantly higher (p < 0.05) than those prepared with coarse RES. Novel RES nanocrystal-loaded ODFs can be a promising delivery system for use as an antioxidant with improved patient compliance by increasing solubility and physical stability of RES.
Prevalence and Associated Factors of Early Initiation of Complementary Feeding among Infants in Hawassa City, Southern Ethiopia
Authors: Bekele Fekadu , Meshesha Berhan , Eshetu Bethlehem 
Published: September 2021

Abstract
Background: Nutrition in infancy and early childhood is a critical determinant of health outcomes and productivity of the individual throughout his/her life years. Thus, World Health Organization and United Nations Children’s Fund recommend initiation of complementary foods at 6 months to ensure optimal child growth and development. In Ethiopia, compliance with infant and young child feeding recommendations is low despite its adoption of different international policies and guidelines. Thus, the aim of this study was to assess the magnitude and associated factors of early initiation of complementary feeding among infants in Hawassa City, Southern Ethiopia, 2021. Methods: A community-based cross-sectional study was conducted in Hawassa City, in January 2021. A systematic random sampling technique was applied to recruit 543 mothers who had infants aged 6 to 12 months. A structured and interviewer-administered questionnaire was used to collect data. by six. A multivariable logistic regression analysis was applied to identify factors associated with the early initiation of complementary feeding. Adjusted odds ratio with corresponding 95% confidence interval was calculated to show the strength of association. Result: A total of 543 mothers/caregivers of infants were interviewed face to face, giving a response rate of 97%. Approximately 38% of mothers initiated complementary foods before six months of age. After adjusting for confounders, maternal employment status [AOR (95%CI): 4.72 (2.84, 7.87)] and postnatal care checkup [AOR (95%CI): 1.92 (1.24, 2.97)] were significantly associated with early initiation of complementary feeding. Conclusion: A high proportion of mothers initiated complementary feeding before six months of infant's age. Postnatal care checkup and mother’s occupational status were significantly associated with early initiation of complementary feeding. Thus, increasing the coverage of postnatal care utilization and creating mother-friendly workplaces for breastfeeding mothers is of paramount importance to realize appropriate complementary feeding practices.
A Simple and Effective Method to Improve Pinnacle Auto-planning Based on Rectal Cancer
Authors: Hua Lei , Chen Gang , Xiao Han , Pan Xiangou , Zhang JianYing 
Published: September 2021

Abstract
Background: Try to re-optimize the results of pinnacle Auto-planning (AP) and explore the feasibility of obtaining more dosiologically advantageous AP plans by reducing "experience-based optimization parameters". Methods: 35 rectal cancer cases with preoperative radiotherapy were selected and all plans are designed retrospectively with Pinnacle9.1 AP. Firstly we take the doctor's clinical prescription as a universal optimization parameters, get the first reference group CP; secondly we set the results of manual plans (MP) which were already used for clinical treatments as the optimization parameters, replacing the physicist's initial experience, get the second reference group IE; at last we reduce the results of MP by 15% as the optimization parameters , get the control group T. By keeping the other optimization conditions unchanged, we designed AP plans for all three groups. Wilcoxon rank sum tests were performed for CP-T and IE-T based on the dosiological parameters of the planning target volume(PTV) and organs at risk(OARs). Results: Dose distribution of all three groups was in a clinically acceptable range. The dose of OARs in T group was significantly lower than CP and IE,the differences were statistically significant. Conclusion: Experience-based AP plan has a space for re-optimization, and appropriately reducing the results of MP as optimization parameters is a simple and feasible way.
Quantum sensing for gravitational cartography
Authors: Stray* Ben , Lamb* Andrew , Kaushik Aisha , Vovrosh Jamie , Rodgers Anthony , Winch Jonathan , Hayati Farzad , Boddice Daniel , Stabrawa Artur , Niggebaum Alexander , Langlois Mehdi , Lien Yu-Hung , Lellouch Samuel , Roshanmanesh Sanaz , Ridley Kevin , de Villiers Geoffrey , Brown Gareth , Cross Trevor , Tuckwell George , Faramarzi Asaad , Metje Nicole , Bongs Kai , Holynski Michael 
Published: September 2021

Abstract
The sensing of gravity has emerged as an important tool in geophysics for applications such as engineering and climate research 1,2,3 where it provides the capability to probe otherwise inaccessible features under the surface of the Earth. Examples include the monitoring of temporal variations such as those found in aquifers4 and geodesy5. However, resolving metre scale underground features is rendered impractical by the long measurement times needed for the removal of vibrational noise6. Here, we overcome this limitation and open up the field of gravity cartography by realising a practical quantum gravity gradient sensor. Our design suppresses the effects of micro-seismic and laser noise, as well as thermal and magnetic field variations, and instrument tilt. The instrument achieves an uncertainty of 20 E (1 E = 10-9 s-2) and is used to perform a 0.5 m spatial resolution survey across a 8.5 m long line, detecting a 2 m tunnel with a signal to noise ratio of 8. The tunnel centre is localised using a Bayesian inference method, determining the centre to within ± 0.19 m in the horizontal direction and finding the centre depth as (1.89 -0.59/+2.3) m. The removal of vibrational noise enables improvements in instrument performance to directly translate into reduced measurement time in mapping. This opens new applications such as mapping the water distribution of aquifers and evaluating impacts on the water table7, detecting new features in archaeology8,9,10,11, determination of soil properties12 and water content13, and reducing the risk of unforeseen ground conditions in the construction of critical energy, transport and utilities infrastructure14, providing a new window into the underground.
A novel radiographic grid aiming device for percutaneous renal puncture
Authors: Xu Guibin 
Published: September 2021

Abstract
Background

This in-vitro study aims to assess the efficacy of a novel radiographic grid aiming device as compared to the conventional “bull’s eye” puncture technique for percutaneous renal puncture.
Methods

This new device uses two radiopaque rings for targeting, somewhat similar to the concept of gun sights. The device is designed to improve the ease and accuracy of the “bull’s eye” puncture technique. We compared this device to the conventional “bull’s eye” puncture technique using a porcine kidney inside a chicken carcass as the study model. Two first-year residents used both the radiographic grid aiming device in turn, Group A, and the conventional bull’s eye technique, Group B, to perform punctures to reach the target porcine calyces in order. Related data were recorded and analyzed.
Results

23 renal calyceal punctures were performed per group. There were no statistical differences in the overall puncture success rate, puncture time, or radiation exposure time and dose between the two groups. The number of punctures required to achieve success was higher in group B and the distance between the puncture site to the center of papillary fornix was shorter in group A, all P < 0.05.
Conclusions

The novel radiographic grid aiming device showed no advantage in the overall success rate for renal puncture. However, it offered the advantages of more precise puncture with fewer puncture attempts. It may serve as a useful tool for training. It may also offer some benefit to surgeons who are novices at percutaneous renal puncture.
Ibrutinib plus obinutuzumab as frontline therapy for chronic lymphocytic leukemia is associated with a lower rate of infusion-related reactions and with sustained remissions after ibrutinib discontinuation: a single-arm, open-label, phase 1b/2 clinical trial NCT0231576
Authors: Castro Januario E. , Lengerke-Diaz Paula A. , Velez-Lujan Juliana , Choi Michale Y. , Moreno-Cortes Eider F. , Forero Jose V. , Garcia-Robledo Juan Esteban , Jacobs Chaja , McCarthy Colin , Heinen Alaina , Amaya-Chanaga Carlos I. , Kipps Thomas J. 
Published: September 2021

Abstract
Ibrutinib-based therapies are costly and require continuous administration. We hypothesized combining BTK inhibition with anti-CD20 monoclonal antibodies would yield deep remissions allowing discontinuation. We enrolled 32 therapy-naïve CLL patients to receive ibrutinib plus obinutuzumab, followed by single-agent ibrutinib. Patients could discontinue ibrutinib after 36 months with sustained complete response (CR). We evaluated treatment safety, efficacy, and outcomes after ibrutinib discontinuation. The overall response rate was 100%, 28% achieved a CR, and 12.5% achieved bone marrow undetectable minimal residual disease. At a three-year median follow-up, 91% remain in remission with 100% overall survival. Five patients in sustained CR stopped ibrutinib and have not progressed. Eight non-CR patients discontinued for other reasons, with only two progressing. The treatment was safe, with a lower IRR rate. All patients responded to treatment with longer time-to-progression after discontinuation of ibrutinib. Our data support the evaluation of ibrutinib discontinuation strategies in more extensive clinical trials.
Characterization of the mitochondrial Huso huso genome with new aspects into its organization with presence of tandem repeat in the 12SrRNA and tRNA-Glu
Authors: Dadkhah Khadijeh , Mianji Ghodrat Rahimi , barzegar Ali , Farhadi Ayoub 
Published: September 2021

Abstract
The sturgeon group is an economically important group in the world due to the production of caviar, and they are also a suitable old species for researching on the evolution of the mitochondrial genome. In H.huso sequencing, we identified a distinct genome organization relative to other species that has never been reported before. In this specie, the mitochondrial genome consisted of 13 genes encoding proteins, 22tRNA and 2rRNA, and two non-coding regions that followed other vertebrates. In addition, H.huso had an pseudo tRNA-Glu between ND6 and Cytb and also had a 52-nucleotide tandem repeat with two replications in the 12SrRNA. This duplication event is related to the slipped strand during replication, which can remain in the strand as a result of mispairing during replication. Furthermore, an 82 bp repeat sequence with three replications was observed in the D-loop control region, which is usually visible in different species. Regulatory elements are also visible in the control region of the mitochondrial genome that include termination sequences and conserved regulatory blocks. Genomic compounds showed the highest conservation in terms of rRNA and tRNA, while protein-encoded genes and non-encoded regions had the highest divergence. The mitochondrial genome was phylogenetically assayed using 13 protein-encoding genes.
Sentiment Analysis Using Treebank Filtered Preprocess with Relevant Vector Boost Classifier
Authors: P.Rajendiran Rajendiran , Priyadarsini P.L.K. 
Published: September 2021

Abstract
The procedure of identifying and classifying opinions in a piece of text to find out whether customer reviews towards a particular product or service are positive, negative, or neutral is termed as sentiment analysis. Stock market prediction is one of the most attractive topics in academic and real-life business. Many data mining techniques about sentiment analysis are suffering from the inaccuracy of prediction. The low classification accuracy has a direct effect on the reliability of stock market indicators. Treebank filtering Data Preprocessing based Ochiai-Barkman Relevance Vector Linear Programming Boost Classification (TFDP-ORVLPBC) technique is used for stock market prediction using sentimental analysis with higher prediction accuracy and lesser classification time for enhancing accuracy of stock market based on product review. Initially, the customer reviews and feedback on services or products are collected from the large database. After that, the collected customer reviews are preprocessed by performing the process such as tokenization, stemming, filtering. In order to achieve sentimental analysis through classifying customer reviews as positive and negative, Ochiai-Barkman Relevance Vector Linear Programming Boost Classification algorithm is used. The Linear Programming Boost Classification algorithm constructs with an empty set of weak classifiers as the Ochiai-Barkman Relevance Vector machine. The customer reviews are classified based on the Ochiai-Barkman similarity coefficient. The ensemble technique combines the weak classification results into strong by minimizing the error. In this way, the classification performance gets improved and the prediction of the stock market is carried out in a more accurate manner. Experimental evaluation is carried out on factors such as prediction accuracy, sensitivity, specificity, and prediction time versus amount of customer reviews.
A Hydraulic Soft Microhand with an Application of Live Insect Manipulation
Authors: Kordmahale Sina Baghbani , Qu Jian , Muliana Anastasia Hanifah , Kameoka Jun 
Published: September 2021

Abstract
We have developed micro scale hydraulic/pneumatic soft grippers and demonstrated the handling of an insect. These grippers are built on Polydimethylsiloxane (PDMS) with the soft material casting technique to form three finger-like columns, which are placed on a circular membrane. The fingers have a length of 1.5mm/2mm and a diameter of 300µm each; the distance between two fingers is 600µm of center-to-center distance. Membrane is built as a 150µm soft skin on the top of a cylindrical void. Applying a pressure difference between the interior of the void and the exterior can bend the membrane. Bending the membrane causes the motion of opening/closing of the gripper, and as a result, the three fingers can grip an object or release it. The PDMS was characterized and the experimental results were used later in Abaqus software to simulate the gripping motion. The produced force and range of deformation of the grippers were investigated by simulation and experiment. The results of the simulation agrees with the experiments. The maximum 543 µN force was measured for the microfluidic compatible microgrippers.Using this microhand gripper, the an ant was manipulated successfully without any damage. Results showed fabricated devices have great potential as a micro/bio manipulator.