bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pottery production from the Deh Dumen Bronze Age graveyard (South-Western Iran): a chemical, mineralogical and physical study
Authors: Oudbashi Omid , Naseri Reza , Cultrone Giuseppe , Egartner Isabel , Arizzi Anna 
Published: July 2021

Abstract
A collection of pottery vessels uncovered during the first season of excavations in the Deh Dumen Bronze Age graveyard (the second half of the third millennium BC) located in south-western Iran were studied by using chemical, mineralogical and physical techniques, with the aim to identify the pottery manufacturing process in this region. The site is located in a region of the Zagros fold and thrust belt that includes carbonate rocks and alluvial deposits. The pottery vessels found in the site present two different fabric types in their fresh surface: bright yellowish hue fabric (TYPE-1) and sandwich-like or black core fabric (TYPE-2) showing presumably different production techniques or workshops. Twenty-four samples from pottery sherds were selected and analysed by X-ray fluorescence (XRF), powder X-ray diffraction (XRD), polarized light microscopy (PLM), and field emission scanning electron microscopy (FESEM). Hydric tests were also performed. Samples were different according to their chemistry having distinguished calcium-rich and calcium-poor ceramics. Al2O3 and Fe2O3 were detected as the other main components of samples besides SiO2 and CaO. The mineralogical and textural characterisation revealed a fine-grained clayey matrix with quartz and feldspar grains in TYPE-1 potteries and large and small calcitic and clayey lumps inclusions in TYPE-2 potteries. Imprints of straw or other plants can be responsible for the higher porosity of some of the potteries. It was found that most of the potteries from the Deh Dumen graveyard were produced by means of a local and traditional pottery manufacturing technique, whilst others may have been produced in different places and transported to the graveyard as ritual offerings.
Primary success of electrical cardioversion for new-onset atrial fibrillation and its association with clinical course in non-cardiac critically ill patients: sub-analysis of a multicenter observational study
Authors: Shima Nozomu , Miyamoto Kyohei , Kato Seiya , Yoshida Takuo , Uchino Shigehiko ,   on behalf of the AFTER-ICU study group, Yoshida Tomonao , Nashiki Hiroshi , Suzuki Hajime , Takahashi Hiroshi , Kishihara Yuki , Nagasaki Shinya , Okazaki Tomoya , Katayama Shinshu , Sakuraya Masaaki , Ogura Takayuki , Inoue Satoki , Uchida Masatoshi , Osaki Yuka , Kuriyama Akira , Irie Hiromasa , Kyo Michihito , Saito Junichi , Nakayama Izumi , Masuda Takahiro , Tsujita Yasuyuki , Okumura Masatoshi , Inoue Haruka , Aoki Yoshitaka , Kondo Takashiro , Nagata Isao , Igarashi Takashi , Saito Nobuyuki , Nakasone Masato 
Published: July 2021

Abstract
Background
Electrical cardioversion (ECV) is widely used to restore sinus rhythm in critically ill adult patients with atrial fibrillation, although its prognostic value is uncertain. This study aims to elucidate the clinical meaning of successful ECV.

Methods
This is a sub-analysis of the AFTER-ICU study, a multicenter prospective study with a cohort of 423 adult non-cardiac patients with new-onset atrial fibrillation (AF). Patients that underwent ECV within 7 days after initial onset of AF were included in the sub-analysis. We compared intensive care unit (ICU) and overall hospital mortality, survival time within 30 days, cardiac rhythm at ICU discharge, and the length of ICU and overall hospital stay between patients whose sinus rhythm was restored immediately after the first ECV session (primary success group) and those in whom it was not restored (unsuccessful group). To find the factors related to the primary success of ECV, we also compared patient characteristics, the delivered energy, and pretreatment.

Results
Sixty-five patients received ECV and were included in this study. Although 35 patients (54%) had primary success, recurrence of AF occurred in 24 of these patients (69%). At ICU discharge, three patients still had AF in the unsuccessful group, but no patients in the primary success group still had AF. ICU mortality was 34% in the primary success group and 17% in the unsuccessful group (P = 0.10). Survival time within 30 days did not differ between the groups. Delivered energy and pretreatment were not associated with primary success of ECV.

Conclusions
The primary success rate of ECV for new-onset AF in adult non-cardiac ICU population was low, and even if it succeeded, the subsequent recurrence rate was high. Primary success of ECV did not affect the rate of mortality. Pretreatment and delivered energy were not associated with the primary success of ECV.

Trial registration
UMIN clinical trial registry, the Japanese clinical trial registry (registration number: UMIN000026401, March 31, 2017).
Total mass estimate of the January 23, 2018, phreatic eruption of Kusatsu-Shirane Volcano, central Japan
Authors: Kametani Nobuko , Ishizaki Yasuo , Yoshimoto Mitsuhiro , Maeno Fukashi , Terada Akihiko , Furukawa Ryuta , Honda Ryo , Ishizuka Yoshihiro , Komori Jiro , Nagai Masashi , Takarada Shinji 
Published: July 2021

AbstractOn January 23, 2018, a small phreatic eruption (VEI = 1) occurred at the Motoshirane Pyroclastic Cone Group in the southern part of Kusatsu-Shirane Volcano in central Japan. The eruption ejected ash, lapillus, and volcanic blocks from three newly opened craters: the main crater (MC), west crater (WC), and south crater (SC). Volcanic blocks were deposited up to 0.5 km from each crater. In contrast, the ash released during this eruption fell up to 25 km ENE of the volcano. The total mass of the fall deposit generated by the eruption was estimated using two methods, yielding total masses of 3.4 × 104 t (segment integration method) and 2.4 × 104 t (Weibull fitting method). The calculations indicate that approximately 70% of the fall deposit was located within 0.5 km of the craters, which was mainly attributed to the low height of the eruption plume.
A rare case of combined thymoma and a multilocular thymic cyst discovered due to chest pain
Authors: Yasuda Kengo , Kidokoro Yoshiteru , Makishima Karen , Matsui Shinji , Nakanishi Atsuyuki , Nozaka Yuji , Oshima Yuki , Kubouchi Yasuaki , Takagi Yuzo , Haruki Tomohiro , Nakamura Hiroshige 
Published: July 2021

Abstract
Background
A thymoma with chest pain and multilocular thymic cysts (MTCs) is very rare.

Case presentation
A 49-year-old man presented to another hospital complaining of an anterior chest pain. Chest computed tomography (CT) showed an anterior mediastinal tumor 60 × 30 × 55 mm in size. The boundary with the pericardium or left brachiocephalic vein seemed to be partially unclear while enhanced by the contrast medium, and so the tumor could have invaded them. No definitive diagnosis of myasthenia gravis was made although the serum anti-acetylcholine receptor antibody count was high. We performed an extended thymectomy with combined partial resection of left brachiocephalic vein, left upper lobe, and left phrenic nerve. He was discharged with no chest pain and no complications post-surgery. The tumor was pathologically type B2 thymoma with hemorrhage necrosis and MTCs, and we diagnosed Masaoka stage II because of no histological infiltration to the organs.

Conclusions
We speculated that hemorrhagic necrosis due to infarction in tumor caused the inflammation to spread to the surrounding organs, which was related to the chest pain and the development of MTCs.
Influenza and pneumococcal vaccination coverage in Latin American patients with systemic lupus erythematosus: a cross-sectional and comparative study
Authors: Chiganer Edson Hernán , Ochi Bruno Camargo , Lessa Carmen Flora 
Published: July 2021

Abstract
Background
Infections are a major cause of morbidity and mortality in systemic lupus (SLE). Vaccination would be an effective method to reduce infection rate. Coverage for influenza and pneumococcus appears to be low in Latin America. The objective of this study was to evaluate vaccination coverage for influenza and pneumococcus in Latin America, causes of non-vaccination and to compare it with European patients.

Methods
A survey was conducted through social networks targeting Latin American lupus patients. A self-report was used to assess the demographics, risk factors for pneumonia, vaccination status, and causes of non-vaccination. The same method was used for European patients. We used binary logistic regression to identify factors associated with pneumococcal and influenza vaccination.

Results
There were 1130 participants from Latin America. Among them, 97% were women with an average of 37.9 years (SD: 11.3) and 46.5% had more than 7 years of disease duration. Two or more risk factors for pneumonia were found in 64.9%. Coverage for influenza and pneumococcal was 42.7 and 25% respectively, being lower than in Europe. Tetanus coverage was the most important predictor for receiving influenza and pneumococcal vaccination. Lack of prescription was the most common cause of non-application (64.6%).

Conclusions
Vaccination coverage for influenza and pneumonia is low in Latin America, especially compared to Europe. It is necessary to make specialists aware of their role in vaccine control and to implement measures to improve coordination between them and general practitioners.
In silico investigations on curcuminoids from Curcuma longa as positive regulators of the Wnt/β-catenin signaling pathway in wound healing
Authors: Reshad Riyan Al Islam , Alam Sayka , Raihan Humaira Binte , Meem Kamrun Nahar , Rahman Fatima , Zahid Fardin , Rafid Md. Ikram , Rahman S. M. Obaydur , Omit Sadman , Ali Md. Hazrat 
Published: July 2021

AbstractBackgroundCurcuma longa(Turmeric) is a traditionally used herb in wound healing. The efficacy of fresh turmeric paste to heal wounds has already been investigated in multiple ethnobotanical studies. Wnt/β-catenin signaling pathway plays a significant role in wound healing and injury repair processes which has been evident in different in vitro studies. This study aims to analyze the potentiality of curcuminoids (curcumin I, curcumin II and curcumin III) fromCurcuma longato bind and enhance the activity of two intracellular signaling proteins- casein kinase-1 (CK1) and glycogen synthase kinase-3β (GSK3B) involved in Wnt/β-catenin signaling pathway. This study is largely based on a computer-based molecular docking program which mimics the in vivo condition and works on a specific algorithm to interpret the binding affinity and poses of a ligand molecule to a receptor. Subsequently, drug likeness property, ADME/Toxicity profile, pharmacological activity, and site of metabolism of the curcuminoids were also analyzed.ResultsCurcumin I showed better affinity of binding with CK1 (− 10.31 Kcal/mol binding energy) and curcumin II showed better binding affinity (− 7.55 Kcal/mol binding energy) for GSK3B. All of the ligand molecules showed quite similar pharmacological properties.ConclusionCurcumin has anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant, and anti-infective properties. Curcumin has also anti-inflammatory and wound healing properties. It hastens wound healing by acting on different stages of the natural wound healing process. In this study, three curcumins fromCurcuma longawere utilized in this experiment in a search for a drug to be used in wound healing and injury repair processes. Hopefully, this study will raise research interest among researchers.
Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms
Authors: Iv Francois , Martins Carla Silva , Castro-Linares Gerard , Taveneau Cyntia , Barbier Pascale , Verdier-Pinard Pascal , Camoin Luc , Audebert Stéphane , Tsai Feng-Ching , Ramond Laurie , Llewellyn Alex , Belhabib Mayssa , Nakazawa Koyomi , Di Cicco Aurélie , Vincentelli Renaud , Wenger Jerome , Cabantous Stéphanie , Koenderink Gijsje H. , Bertin Aurélie , Mavrakis Manos 
Published: July 2021

ABSTRACT
Septin GTP-binding proteins contribute essential biological functions that range from the establishment of cell polarity to animal tissue morphogenesis. Human septins in cells form hetero-octameric septin complexes containing the ubiquitously expressed SEPT9 subunit (also known as SEPTIN9). Despite the established role of SEPT9 in mammalian development and human pathophysiology, biochemical and biophysical studies have relied on monomeric SEPT9, thus not recapitulating its native assembly into hetero-octameric complexes. We established a protocol that enabled, for the first time, the isolation of recombinant human septin octamers containing distinct SEPT9 isoforms. A combination of biochemical and biophysical assays confirmed the octameric nature of the isolated complexes in solution. Reconstitution studies showed that octamers with either a long or a short SEPT9 isoform form filament assemblies, and can directly bind and cross-link actin filaments, raising the possibility that septin-decorated actin structures in cells reflect direct actin–septin interactions. Recombinant SEPT9-containing octamers will make it possible to design cell-free assays to dissect the complex interactions of septins with cell membranes and the actin and microtubule cytoskeleton.
Passive Recovery Strategies after Exercise: A Narrative Literature Review of the Current Evidence
Authors: Cullen Michael-Flynn L. , Casazza Gretchen A. , Davis Brian A. 
Published: July 2021

Abstract
Passive recovery techniques are popular and offer a diverse spectrum of options for athletes and the clinicians providing care for them. These techniques are intended to minimize the negative effects of training or competition, thus enabling the athlete a quicker return to peak performance. Current evidence demonstrates improved athlete recovery with compression garments, cold water immersion, partial body cryotherapy, hyperbaric oxygen, and vibratory therapies. Other popular modalities, such as compression devices, whole body cryotherapy, percussive gun-assisted therapy, neuromuscular electrical stimulation, and pulsed electromagnetic therapy lack convincing evidence concerning athlete recovery. This article seeks to review the current literature and offer the reader an updated understanding of the mechanisms for each modality and the evidence regarding each modality's potential benefit in an athlete's recovery strategy.
Helping Children with Obesity “Move Well” To Move More: An Applied Clinical Review
Authors: Tsiros Margarita D. , Vincent Heather K. , Getchell Nancy , Shultz Sarah P. 
Published: July 2021

Abstract
Children with obesity experience musculoskeletal pain and reduced physical function and well-being, which collectively impact their fitness, strength, motor skills, and even their ability to undertake simple tasks, like walking and climbing stairs. Disrupting obesity-related disability may be critical to increasing children's physical activity. Thus, barriers to movement should be considered by health practitioners to improve the efficacy of prescribed physical activity. This applied clinical review highlights key subjective and objective findings from a hypothetical case scenario, linking those findings to the research evidence, before exploring strategies to enhance movement and increase physical activity.
Suggested Curricular Guidelines for Musculoskeletal and Sports Medicine in Physical Medicine and Rehabilitation Residency Training
Authors: Olufade Oluseun A. , Patel Amrish , Cherian Chris , Waterbrook Anna L. , Zaremski Jason L. , Sussman Walter I. , Bowers Robert , Hrubes Melody , Myers Rebecca A. 
Published: July 2021

Abstract
A sports medicine physician manages musculoskeletal (MSK) injuries and sport-related medical and MSK conditions of patients of all ages and abilities. Physical medicine and rehabilitation physicians (physiatrists) must be adequately trained to provide this care for all patients including, but not limited to, athletes participating in organized sports, the weekend warrior as well as athletes with disabilities. Accreditation Council of Graduate Medical Education core requirements and basic guidelines help physiatry residency training programs develop and implement residency curriculums. The goal of this article is to provide suggested curricular guidelines to optimize physiatrist training in MSK and sports medicine.
Creatine Supplementation: An Update
Authors: Hall Matthew , Manetta Elizabeth , Tupper Kristofer 
Published: July 2021

Abstract
Creatine is a popular and widely used ergogenic dietary supplement among athletes, for which studies have consistently shown increased lean muscle mass and exercise capacity when used with short-duration, high-intensity exercise. In addition to strength gains, research has shown that creatine supplementation may provide additional benefits including enhanced postexercise recovery, injury prevention, rehabilitation, as well as a number of potential neurologic benefits that may be relevant to sports. Studies show that short- and long-term supplementation is safe and well tolerated in healthy individuals and in a number of patient populations.
Predicting the pathological grade of breast phyllodes tumors: a nomogram based on clinical and magnetic resonance imaging features
Authors: Ma Xiaowen , Shen Lijuan , Hu Feixiang , Tang Wei , Gu Yajia , Peng Weijun 
Published: July 2021

Objective: To explore the potential factors related to the pathological grade of breast phyllodes tumors (PTs) and to establish a nomogram to improve their differentiation ability. Methods: Patients with PTs diagnosed by post-operative pathology who underwent pretreatment magnetic resonance imaging (MRI) from January 2015 to June 2020 were retrospectively reviewed. Traditional clinical features and MRI features evaluated according to the fifth BI-RADS were analyzed by statistical methods and introduced to a stepwise multivariate logistic regression analysis to develop a prediction model. Then, a nomogram was developed to graphically predict the probability of non-benign (borderline/malignant) PTs. Results: Finally, 61 benign, 73 borderline and 48 malignant PTs were identified in 182 patients. Family history of tumor, diameter, lobulation, cystic component, signal on fat saturated T2 weighted imaging (FS T2WI), BI-RADS category and time–signal intensity curve (TIC) patterns were found to be significantly different between benign and non-benign PTs. The nomogram was finally developed based on five risk factors: family history of tumor, lobulation, cystic component, signal on FS T2WI and internal enhancement. The AUC of the nomogram was 0.795 (95% CI: 0.639, 0.835). Conclusion: Family history of tumor, lobulation, cystic components, signals on FS T2WI and internal enhancement are independent predictors of non-benign PTs. The prediction nomogram developed based on these features can be used as a supplemental tool to pre-operatively differentiate PTs grades. Advances in knowledge: More sample size and characteristics were used to explore the factors related to the pathological grade of PTs and establish a predictive nomogram for the first time.
X-ray checks of NG tube position: a case for guided tube placement
Authors: Taylor Stephen , Manara Alex R 
Published: July 2021

Objectives:Checking nasogastric (NG) tube position by X-ray is too late to prevent 1.5% of blind tube placements entering the lung and results in delays to feeding and drugs. We audit the safety of the tube position and delay incurred by X-ray.Methods:From Radiology reports, we determined whether tube position was safe for feeding, factors associated with an X-ray request and the time delay from X-ray request to that report. For tubes misplaced into the lung, the distance from the carina to tube tip was measured and compared with that from published records of guided tube placement.Results:From 1 July 2019 to 30 June 2020, 1934 X-rays were done to check NG tube position in 891 patients. Gastric placement was confirmed in 85% but, because of tube proximity to the oesophagus, only 73% were deemed safe to feed. The 2.2% of tubes reported to be in the lung were a median of 18 cm beyond the carina compared to 12 cm and 0 cm for electromagnetic and direct vision methods of guided placement. X-ray checks delayed feed and drug treatment by >2 h in 51% of placements and 33% of patients required >3 X-rays during their enteral episode.Conclusion:X-ray checks are common and detect a high percentage of unsafe tube placements, leading to repeated X-ray and delayed delivery of drugs and nutrition. Interpretation can be difficult even when following standard national criteria and post-placement X-ray cannot prevent deep lung placement. Guided or combined methods of confirming tube placement should be investigated.Advances in knowledge:Reports included 27.5% of placements as unsafe, 2.2% in the lung at a median depth of 18 cm beyond the carina and too late to prevent 7 pneumothoraces. X-rays were repeated >3 times in 33% of patients over their enteral course and we are associated with clinically significant delays to drug treatment (and nutrition) in 51%; combined methods of tube confirmation or guided placement may be safer and more efficient.
Impact of double reading on NI-RADS diagnostic accuracy in reporting oral squamous cell carcinoma surveillance imaging – a single-center study
Authors: Elsholtz Fabian Henry Jürgen , Ro Sa-Ra , Shnayien Seyd , Dinkelborg Patrick , Hamm Bernd , Schaafs Lars-Arne 
Published: July 2021

Objectives: The Neck Imaging Reporting and Data System (NI-RADS) is an increasingly utilized risk stratification tool for imaging surveillance after treatment for head and neck cancer. This study aims to measure the impact of supervision by subspecialized radiologists on diagnostic accuracy of NI-RADS when initial reading is performed by residents. Methods: 150 CT and MRI datasets were initially read by two trained residents, and then supervised by two subspecialized radiologists. Recurrence rates by NI-RADS category were calculated, and receiver operating characteristic (ROC) curves were plotted. After dichotomization of the NI-RADS system (category 1 vs categories 2 + 3+4 and categories 1 + 2 vs 3 + 4), sensitivity, specificity, positive and negative predictive value were calculated. Results: 26% of the reports were modified by the supervising radiologists. Area under the curve of ROC plots values of the supervision session were higher than those of the initial reading session for both the primary site (0.89 vs 0.86) and the neck (0.94 vs 0.91), but the difference was not statistically significant. For dichotomized NI-RADS category assignments, differences between the initial reading and the supervision session were statistically significant regarding specificity and PPV for the primary site (1 + 2 vs 3 + 4 and 1 vs 2 + 3+4) or even for both sites combined (1 vs 2 + 3+4). Conclusion: NI-RADS enables trained resident radiologists to report surveillance imaging in patients with treated oral squamous cell carcinoma with high discriminatory power. Additional supervision by a subspecialized head and neck radiologist particularly improves specificity of radiological reports.