bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Longitudinal Strain as a Predictor of Chemotherapy-Induced Cardiotoxicity
Authors: Avila Monica Samuel , Alves Marco Stephan Lofrano , Ayub-Ferreira Silvia Moreira , Junior Mauro Rogerio de Barros Wanderley , Cruz Fatima das Dores , Brandão Sara Michelly Gonçalves , Hajjar Ludhmila Abrahão , Filho Roberto Kalil , Cruz Cecilia Beatriz Bittencourt Viana , Abduch Maria Cristina , Moleta Danilo Bora , Bocchi Edimar Alcides 
Published: December 2021

Abstract
Background
Chemotherapy-induced cardiotoxicity (ChC) is an important complication among patients receiving anthracyclines. Biomarkers and imaging parameters have been studied for their ability to identify patients at risk of developing this complication. Left ventricle global longitudinal strain (LV-GLS) has been described as a sensitive parameter for detecting systolic dysfunction, even in the presence of preserved left ventricle ejection fraction (LVEF).
Objective
to evaluate the role of the LV-GLS as a predictor of ChC.
Methods
This study is a post-hoc analysis of CECCY trial (Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity) that evaluated the primary prevention of cardiotoxicity with carvedilol during doxorubicin chemotherapy in a population with breast cancer. Cardiotoxicity was defined as a reduction ≥10% in LVEF. LV-GLS was obtained before chemotherapy in patients with no prior cardiovascular disease or echocardiogram abnormalities.
Results
Thirty-one patients who had a complete echocardiography study including measurement of LV-GLS before chemotherapy were included in this analysis. An absolute LV-GLS <16.9% before chemotherapy showed 100% sensitivity and 73% specificity for predicting cardiotoxicity (AUC=0.85; 95%CI 0.680 – 0.959, p<0.001). In this population, LVEF values before chemotherapy did not predict ChC (95%CI 0.478 to -0.842, p=0.17). The association of low LV-GLS (<17%) and BNP serum levels (>17 pg/mL) two months after chemotherapy increased the accuracy for detecting early onset ChC (100% sensitivity, 88% specificity, AUC=0.94; 95%CI 0.781 – 0.995, p<0.0001).
Conclusions
Our data suggest that LV-GLS is a potential predictor of chemotherapy-induced cardiotoxicity. Larger studies are needed to confirm the clinical relevance of this echocardiographic parameter in this clinical setting.
FG-Droid: Grouping Based Feature Size Reduction for Android Malware Detection through Machine Learning
Authors: ARSLAN Recep Sinan 
Published: December 2021

Abstract
The number of applications prepared for use on mobile devices has increased rapidly with the widespread use of the Android OS. This has resulted in the undesired installation of Android apks that violate user privacy or malicious. The increasing similarity between Android malware and benign applications makes it difficult to distinguish them from each other and causes a situation of concern for users. In this study, FG-Droid, a machine-learning based classifier with an efficient working system, using the method of grouping the features obtained by static analysis, was proposed. It was created as a result of experiments with Machine learning (ML), DNN, RNN, LSTM and GRU based models using Drebin, Genome and Arslan datasets. Experimental results reveal that FG-Droid has achieved 97.7% AUC score with a vector includes only 11 static features, and ExtraTree algorithm. FG-Droid analyze the applications with using the least number of features compare to previous studies, and required the least processing time for training and prediction. As a result, it has been shown that Android malware can be detected in high accuracy rate with an effective feature set and there is no need to use a large number of features extracted with different techniques (static, dynamic or hybrid).
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.
Authors: Chakravarthy Ankur , Reddin Ian , Henderson Stephen , Dong Cindy , Kirkwood Nerissa , Jeyakumar Maxmilan , Rothschild-Rodriguez Daniela , Gonzalez-Martinez Natalia , McDermott Jacqueline , Su Xiaoping , Egawa Nagayasau , Fjeldbo Christina , Skingen Vilde , Halle Mari , Krakstad Camilla , Soleiman Afschin , Sprung Susanne , Ellis Peter , Wass Mark , Michaelis Martin , Lyng Heidi , Fiegl Heidelinde , Salvesen Helga , Thomas Gareth , Doorbar John , Chester Kerry , Feber Andrew , Fenton Tim 
Published: December 2021

Abstract
Human papillomavirus (HPV)-associated cervical cancer represents one of the leading causes of cancer death worldwide. Although low-middle income countries are disproportionately affected, our knowledge of the disease predominantly originates from populations in high-income countries. Using the largest multi-omic analysis of cervical squamous cell carcinoma (CSCC) to date, totalling 643 tumours and representing patient populations from the USA, Europe and Sub-Saharan Africa, we identify two CSCC subtypes (C1 and C2) with differing prognosis. C1 tumours are largely HPV16-driven, display increased cytotoxic T-lymphocyte infiltration and frequently harbour PIK3CA and EP300 mutations. C2 tumours are associated with shorter overall survival, are frequently driven by HPVs from the HPV18-containing alpha-7 clade, harbour alterations in the Hippo signalling pathway and increased expression of immune checkpoint genes, B7-H3 (also known as CD276) and NT5E (also known as CD73) and PD-L2 (also known as PDCD1LG2). In conclusion, we identify two novel, therapy-relevant CSCC subtypes that share the same defining characteristics across three geographically diverse cohorts.
Small reorganization energy acceptors enable low energy losses in non-fullerene organic solar cells
Authors: Shi Yanan , Chang Yilin , Lu Kun , Chen Zhihao , Zhang Jianqi , Yan Yangjun , Qiu Dingding , Liu Yanan , Adil Muhammad Abdullah , Ma Wei , Hao Xiaotao , Zhu Lingyun , Wei Zhixiang 
Published: December 2021

Abstract
Minimizing the energy loss is of critical importance in the pursuit of attaining high-performance organic solar cells (OSCs). Interestingly, electron-vibration coupling (namely reorganization energy) plays a crucial role in the photo-electric conversion processes. However, a molecular understanding of the relationship between the reorganization energy and the energy loss has rarely been studied. Here, two new acceptors Qx-1 and Qx-2 with quinoxaline (Qx)-containing fused core were designed and synthesized. The results indicate that the reorganization energies of these two acceptors during the photoelectric conversion processes are substantially smaller than the conventional Y6 acceptor, which is beneficial for improving the exciton lifetime and diffusion length, promoting charge transport and reducing the energy loss originating from exciton dissociation and non-radiative recombination. As a result, an outstanding power conversion efficiency (PCE) of 18.2% with high Voc above 0.93 V in the PM6:Qx-2 blend, accompanying a significantly reduced energy loss of 0.48 eV. To the best of our knowledge, the obtained energy loss is the smallest for the binary OSCs with PCEs over 16% reported to date. This work underlines the importance of the reorganization energy in achieving small energy loss in organic active materials and paves a new way to obtain high-performance OSCs.
Microstructure Transformation In Palm-Fiber Cell Wall And Its Influence On the Fiber's Mechanical Properties During Alkali Treatment
Authors: Jing Lingxiao , Jiang Ying , Deng Penghu , Wang Yuehan , Ma Yifa , Zhang Tonghua 
Published: December 2021

Abstract
In this study, we examined the microstructure transformation of palm fiber and the influence of this transformation on the fiber mechanical properties during alkali treatment. The fibers were treated with different concentrations of NaOH to study the change rules of the microstructure and the tensile properties. FT-IR microspectroscopic imaging and confocal laser scanning microscopy were adopted to observe microstructure transformation during alkali treatment. Research results showed that the hemicellulose and lignin in the fiber cell wall were removed by alkali treatment, leading to a rearrangement of cellulose chains. The tensile properties palm fibers were significantly improved because of crystallinity alterations in the cell walls after alkali treatment. This study might provide a basis for palm fiber’s high-value utilization in the field of materials.
Nutrient Intakes of Canadian Children and Adolescents: Results from the Canadian Community Health Survey (CCHS) 2015 – Nutrition Public Use Microdata Files
Authors: Ng Alena (Praneet) , Ahmed Mavra , L'Abbe Mary 
Published: December 2021

Abstract
Background: Up-to-date and appropriate estimates of the usual intakes of key nutrients are crucial for monitoring the nutritional adequacy of the Canadian population. Comprehensive, nationally-representative nutrient estimates for Canadian children and adolescents are available using data from the Canadian Community Health Survey (CCHS) – Nutrition 2004, however results are scarce for the most-recent 2015 data. The objective of this research was to assess nutrient intakes of Canadian children and adolescents using data from the CCHS 2015 Public Use Microdata Files (PUMF) Methods: Participants’ first 24-hr dietary recall, and the second-day recall from a subset of participants were used to estimate usual intakes of macronutrients, vitamins and minerals in children and adolescents (2-18 years). Usual intakes by Dietary Reference Intake (DRI) age-sex groups were estimated using the National Cancer Institute (NCI) method, adjusted for age, sex, misreporting status, weekend/weekday, and sequence of recall analyzed (first/second), with consideration for outliers (N=5,493). Usual intakes from food and beverages were assessed for prevalence of inadequacy in relation to the DRI recommendations. Results: Children 2-3y consumed a percentage of total energy from protein above the Acceptable Macronutrient Distribution Range (AMDR). Among children and adolescents, 71% met the AMDR for carbohydrates and 63-71% met the AMDR for total fat. With the exception of calcium and vitamin D, a very low prevalence (<10%) of inadequate intakes was observed for select micronutrients among Canadian children 2-8y, while a substantial proportion of adolescents (>15%) did not meet requirements for vitamin A, vitamin C, vitamin D, calcium, magnesium and zinc.Conclusions: Canadian children and adolescents may not be meeting recommendations for short fall nutrients such as calcium, potassium, vitamin A and vitamin D. Fibre intake continues to remain low, while sodium intake exceeded recommendations. These findings provide important, updated baseline estimates on the nutrient intakes of this subpopulation in Canada for continued monitoring of adherence to the 2019 Canada’s Food Guide and may be useful to inform future public health nutrition policies, programs and initiatives.
Whole-genome Sequencing of Angioimmunoblastic T-Cell Lymphoma Combined With Plasma Cell Leukemia: A Case Report and Review of the Literature
Authors: Yang Yang , Zhang Enfan , Cai Zhen , He Jingsong 
Published: December 2021

Abstract
Purpose Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphomas, sometimes involves proliferation of plasma cells. Currently, only 7 cases of AITL with monoclonal plasmacytosis have been reported. However, the molecular mechanisms underlying the interaction between monoclonal plasma cells and T cells have not been identified. We describe a rare case of AITL with plasma cell leukemia (PCL) in this report. Methods The patient was a 67-year-old female diagnosed with AITL and PCL. CD138 positive plasma cells and CD138-negative mixed bone marrow populations of this patient were collected for whole-genome sequencing (WGS). A review of the literature on AITL cases with monoclonal plasma cells is presented.Results WGS showed that the two cell populatoins shared 282 non-synonymous single nucleotide variants (SNVs) and excess of G to A and C to T transitions. We identified 14 potential driver genes in this patient. Functional enriched analysis of mutant genes confirmed several significantly enriched pathways, including VEGF signaling. The patient was treated with one cycle of PD (combined Bortezomib and Dexamethasone) and Chidamide. However, the patient developed severe pneumonia and pancytopenia, refused to receive further treatment, and died one week after discharge. Conclusion Being aware of the coexistence of PCL and AITL is important for accurate diagnosis and appropriate treatment. In addition, our results suggested the involvement of a group of genes and pathways in AITL with coexisting PCL, providing valuable information for further exploration of the underlying molecular mechanisms.
A New Systematic Encoding Circuit of Hamming (15, 11) Using Low-Power XOR-FS-GDI Based Logic Gate: Fast Computing and Efficient Area FEC
Authors: El-Bendary Mohsen , El-Badry O 
Published: December 2021

Abstract
Due to the power efficiency importance of digital signal processing and data protection in different communications systems, this paper proposes an efficient design of different Hamming Codes utilizing Full Swing- Gate Diffusion Input (FS-GDI) approach. The proposed codes design aims to improve the power efficiency and the required area through reducing the required number of transistors. FS-GDI is a new low power VLSI design approach, it is a power effective approach for realizing the different logic gates. In this work, the Hamming codes (11, 7) and (15, 11) are designed by utilizing the original GDI, FS-GDI and the traditional CMOS approaches. The amount of consumed power, delay time, Power Delay Product (PDP) and hardware simplicity-Number of Transistors (No. Ts) are employed as a metrics for evaluating the efficiency of the proposed design compared to the traditional design. The design simulation experiments are executed utilizing Cadence Virtuoso simulator package under 65nm technology. The simulation experiments revealed these proposed codes achieve delay time reduction by 52.91% and 10% for Hamming codes (7, 4) and (11, 7), respectively On the other hand, the Hardware (H/W) of these codes became more simple where the H/W simplicity of the used Hamming codes is reduced 50 % CMOS approaches respectively. From the results analysis, the proposed design achieves efficient power and the delay optimizing of Hamming codes utilizing the FS-GDI approach. On the other hand, the power consumption and area in communications systems due to the encoding process can be reduces.
Protective effects of phytomediated synthesized magnesium hydroxide nanomaterials using Monodora myristica against diabetes-associated hepatopathy, nephropathy and neuropathy in streptozotocin-exposed rat
Authors: Afolabi Olakunle Bamikole , Oloyede Omotade I , Aluko Bukola T , Johnson Jonathan 
Published: December 2021

Abstract
There is recently a fast growing interest in green nanotechnology as a better approach for managing diabetes mellitus (DM) and its associated complications. This study therefore aimed at exploring the protective potentials of biogenic phytomediated magnesium-based nanoparticles using Monodora myristica seed (Mg(OH)2NP-Mm) against streptozotocin-induced diabetic hepatopathy, nephropathy and neuropathy in Wistar rats. Mg(OH)2NP-Mm was biosynthesized and characterized using standard techniques. Forty-eight (48) adult male Wistar rats weighing 150-200 g, were indiscriminately grouped into eight (8) groups of six (6) rats (n=6) each. Diabetes was induced with a low dose of streptozotocin (STZ) (55 mg/kg bw) and diabetic animals administered 50, 100, 150 and 200 mg/kg bw Mg(OH)2NP-Mm for 21 days, while control groups received glibenclamide (5 mg/kg bw) and Mg(OH)2-STD (150 mg/kg bw), respectively. In this study, treatment with Mg(OH)2NP-Mm caused a significant (p < 0.05) improvement in fasting blood sugar (FBG), serum hepatic biomarkers (AST, ALT and ALP activities), renal clearance markers (creatinine and urea), total protein (TP) and bilirubin. Enzymatic and non-enzymatic antioxidants, as well as histomorphological examinations indicated a significant (p < 0.05) restoration of the hepatic, renal and brain tissues. This finding therefore, hypothesizes attenuation of redox imbalance which probably could be the basis for the protective effect demonstrated by Mg(OH)2NP-Mm in the tissues examined from STZ-induced diabetic rats.
The Effect of Ionic Strength and pH on the Dewatering Rate of Cellulose Nanofibril Dispersions
Authors: Fall Andreas , Henriksson Marielle , Karppinen Anni , Opstad Anne , Heggset Ellinor Bævre , Syverud Kristin 
Published: December 2021

Abstract
Cellulose nanofibrils, CNFs, show a great potential in many application areas. One main aspect limiting the use of the material is the slow and energy demanding dewatering of CNF suspensions. Here we investigate the dewatering with a piston press process. Three different CNF qualities, two laboratory grades (high and low charge) and one industrial grade (low charge) were tested. The chemical conditions were varied by changing salt concentration (NaCl) and pH. For the original suspensions, the dewatering rate is substantially slower for the high charge CNFs. However, by changing the conditions it dewatered as fast as the two low charge CNFs, even though salt/acid additions also improved dewatering rate for these two CNFs. Finally, by tuning the conditions fast dewatering could be obtained with only minor effect on strength and barrier performance of films prepared from the CNFs.
Mega-Environment Analysis To Assess Adaptability, Stability, And Genomic Predictions In Grain Sorghum Hybrids
Authors: Fonseca Jales Mendes Oliveira , Perumal Ramasamy , Klein Patricia E. , Klein Robert R. , Rooney William L. 
Published: December 2021

Abstract
Multi-environment trials (MET) are fundamental for assessing genotype-by-environment interaction (GxE) effects, adaptability and stability of genotypes and provide valuable information about target regions. As such, a MET involving grain sorghum hybrid combinations derived from elite inbred lines adapted to diverse sorghum production regions was developed to assess agronomic performance, stability, and genomic-enabled prediction accuracies within mega-environments (ME). Ten females and ten males from the Texas A&M and Kansas State sorghum breeding programs were crossed following a factorial mating scheme to generate 100 hybrids. Grain yield, plant height, and days to anthesis were assessed in a MET consisting of ten environments across Texas and Kansas over two years. Genotype plus Genotype-by-block-of-environment biplot (GGB) assessed ME, while the "mean-vs-stability" view of the biplot and the Bayesian Finlay-Wilkinson regression evaluated hybrid adaptability and stability. A genomic prediction model including the GxE effect was applied within ME to assess prediction accuracy. Results suggest that grain sorghum hybrid combinations involving lines adapted to different target regions can produce superior hybrids. GGB confirmed distinct regions of sorghum adaption in the U.S. Further, genomic predictions within ME reported inconsistent results, suggesting that additional effects rather than the correlations between environments are influencing genomic prediction of grain sorghum hybrids.
Synthesis and Biological Evaluation of Prodrugs For Nitroreductase Based 4-β-Amino-4'-Demethylepipodophyllotoxin As Potential Anticancer Agents
Authors: Wu Zhengrong , Deng Wei , He Dian 
Published: December 2021

Abstract
A series of prodrugs for nitroreductase based 4-β-amino-4'- Demethylepipodophyllotoxin as potential anticancer agents were synthesized, and their antiproliferative activities in vitro showed compounds 2b (IC50=0.77, 0.83 and 1.19 μM) and 2d (IC50=0.98, 0.91 and 1.58 μM) were greatly selectively toxic to tumor cells A-549, HeLa and HepG2, respectively, and lower damage to normal WI-38 cells in comparison with positive agent Etoposide and Demethylepipodophyllotoxin, and induced cell cycle arrest in the G2/M phase with a concomitant decrease in the population of G1 phase in HeLa cells, which were accompanied by apoptosis. Furthermore, Molecular docking model showed that compounds 2b and 2d appeared to form stable bonds with NTR 1DS7. Taken together, these conjugates have the potential to be developed as anti-tumor drugs.
Solvation Data for the Redox Interaction Between Nano Cobalt Sulfate (NCS) and Fuchsin Acid (FA) Using Doped Nano Composite+ Multicarbon Nanotubes Glassy Carbon Electrode at Different Temperatures
Authors: Gomaa Esam A , Killa H A , Fathi H , Farouk A 
Published: December 2021

Abstract
Preparation of nano tantalum pentoxide and nano cobalt sulfate were prepared by ball milling using Retsch MM2000 apparatus with three stainless steel balls having diameter 12 mm.Preparation of new working electrode was done by adding nano tantalum petoxide to multicarbonnatubes and carbon with specific ratioand finish nano paste put at the tip of glassy carbon electrode and used for use.The redox reaction of nano cobalt sulfate were studied in 0.1M KBr alone at two temperatures 292.15K and 297.15 using cyclic voltammetry.Different solvation and kinetic parameters were calculated at the used two temperatures and their data were discussed.Interaction parameters of the nano cobalt sulfate with Fucgsin acid dye was done to study the complexationcharcheterbeteen the two cyclic voltammetrically and the resulted data are discussed.Different thermodynamic data were evaluated for the interaction of nanocobal sulfate NCS with Fuchsin Acid, FA like stability constants, Gibbs free energies of complexation, enthalpies and entropies were evaluated and their values were discussed
Pregnancy-related Type Citrullinemia Type 1: an Analysis of 14 Cases and Review of the Literature
Authors: Li Jiapo , Zhang Liyang , Wang Ruochen , Li Fan , Abdelrahim Maryam F. , Huang Ling , Qiao Chong 
Published: December 2021

Abstract
Citrullinemia type 1 (CTLN1) is a rare autosomal recessive urea cycle disorder, without functional argininosuccinate synthase (ASS) enzyme, mostly occurring in newborns and infants, but it has been reported having an adult-onset in carriers of the pathogenic gene, and even more rarely, the onset of the disease is pregnancy related. The diagnosis and management process of pregnancy-related type citrullinemia 1 was found very challenging in the clinical practice. Citrullinemia type 1 was, often seen in newborns with a worldwide prevalence of 1:44,300-250,000, characterized by hyperammonemia and elevated citrulline levels in blood and urine as clinical features. Since 1980, only 14 cases with onset during pregnancy and puerperium have been reported. This review provides an overview of the relationship between Citrullinemia type 1 and pregnancy and discusses the mechanisms, clinical manifestations and genetic characteristics of pregnancy-related onset.