bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forced Degradation Study for Simultaneous Quantification of Aspirin and Omeprazole in Pharmaceutical Dosage form by RP-HPLC
Authors: Chandarana Chandni , Kapupara Pankaj , Prajapati Parixit 
Published: December 2021

Aims: To study force degradation of aspirin and omeprazole simultaneously by RP-HPLC method
Study design: RP-HPLC method was used to measure % degradation.
Place and Duration of Study: Study was carried out at center of excellence, G.I.D.C., vapi-396195, Gujarat, India between June 2019 to march 2020.
Methodology: A force degradation study of aspirin and omeprazole was carried out simultaneously. The drugs were subjected to various degradation conditions like hydrolysis by acid and base, Oxidative degradation, and thermal degradation study.
Results: For acidic condition, the degradation was found to be 32.63 % for aspirin and 61.64 % for omeprazole. For basic condition, the degradation was found to be 10.17 % for aspirin and 4.29 % for omeprazole. By oxidative hydrolysis, the aspirin was degraded by 15.48 % and omeprazole was degraded by 26.38 %. By thermal degradation, 0.37 % degradation was observed for aspirin and 4.32 % degradation for omeprazole.
Conclusion: In this proposed method the retention time for drug is less than 8 min, which is less then available method. For omeprazole, strong degradation was observed in acidic conditions and mild in basic hydrolysis conditions. For aspirin, more degradation was observed in basic conditions than acidic hydrolysis. Both drugs were degraded in oxidative conditions using 3% H2O2. Omeprazole degraded more than aspirin by dry heat degradation. The method was successfully applied for the quantitative determination of both Active Pharmaceutical Ingredients.
Effectual Physiotherapy Treatment in a 16 Year Old Case of Atrial Septal Defect- A Single Case Study
Authors: Daga Shreya , Walke Rashmi , Bhakaney Pallavi R. , Vishnuvardhan . , Kumbhare Ruhi , Jain Moli 
Published: December 2021

Background: Paediatric cardiac surgeries have an immense survival rate and rehabilitation plays a major role in such cases. Many patients are diagnosed with septal defects or valve defects at birth which come sunder cardiac surgeries.
Case Presentation: This is a case of 16 year old boy who had atrial septal defect and underwent atrial septal defect closure.
Investigations: 2D echocardiography revealed atrial septal defect.
Management: Physiotherapy intervention included patient education, breathing retraining, airway clearance techniques, positioning, and psychological support and mobility program. Outcome measures have shown enhancement in functional independence and performance of activities of daily living.
Conclusion: The evidence from this study suggest that paediatric cardiac rehabilitation found to play a pivotal role in managing a patient who had atrial septal defect.
Antioxidant and Xanthine Oxidase Inhibitory Potential of Aqueous Extract of Ferula Asafoetida
Authors: Gopika G. G. , Gayathri R. , Priya V. Vishnu , Selvaraj J. , Kavitha S. 
Published: December 2021

Background: Ferula asafoetida is a dried latex that is exuded from rhizome or taproot species. Organosulfides are primarily responsible for flavour and odour of asafoetida.Ferula asafoetida is a natural medicine good for asthma and bronchitis. is also used to relieve stomach gas, digestive issues. It is usually added while cooking to hormonise the sweet, sour, salty, spicy taste of the food. Increased activity of xanthine oxidase is involved in the medical condition known as gout, which is characterized by hyperuricemia that leads to deposition of uric acid in the joints resulting in painful inflammation.
Aim: To analyse the anti-oxidant and xanthine oxidase inhibitory potential of aqueous extract of Ferula asafoetida.
Materials and Methods: Preparation of the aqueous seed extract of Ferula asafoetida done by hot percolation method. Phytochemical screening, in vitro antioxidant activity and xanthine oxidase inhibitory potential was done by standard procedures. The data were analyzed statistically by a one - way analysis of variance (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the groups. The results with the p<0.05 level were considered to be statistically significant.
Results: The phytochemical screening revealed that the extract is rich in phytoconstituents. DPPH radical scavenging activity established the potent in vitro antioxidant activity (p<0.05) of Ferula asafoetida extract. The extract was also efficient in inhibiting the activity of xanthine oxidase enzyme (p<0.05) in a concentration dependent manner.
Discussion: The extract has potent antioxidant and xanthine oxidase inhibitory potential, although the activities are less compared to the standard drug.
Conclusion: The Ferula asafoetida extract can be used to treat gout and to combat various other disorders associated with xanthine oxidase activity.
COVID-19 Vaccination Status amongst College Students and Staff during Offline Classes
Authors: Padma A. Sai , Babu N. Chandan 
Published: December 2021

Aim: To understand the status of COVID-19 vaccination amongst students and staff during offline classes.
Study Design: Questionnaire with open ended questions was sent to participants through social media.
Place and Duration of Study: The present study was conducted in Bhavan’s Vivekananda College of Science, Humanities and Commerce, Sainikpuri, Secunderabad from 12th-15th September, 2021.
Methodology: Questionnaire was sent to all staff members, second and third year students of undergraduate and first year students of post graduate programmes who were attending classes during the study period. Total 1263 responses were received out of approximately 2500 students.
Results: The survey results have shown that 1128 participants (89.3%) out of 1263 have received vaccination and out of them, 742 participants (65.78%) have received single dose of vaccine and 386 (34.22%) participants have received two doses. Majority of them have received Covishield (74.5%), followed by Covaxin (24.11%).
Conclusion: The present study necessitates all educational institutions to conduct similar kind of studies to understand the current status of vaccination and safety measures taken by students and staff during Covid-19 pandemic during offline classes. This will help to keep the campuses safe and prevent further spread of infection to avoid third wave of corona virus.
Assess the Level of Stress during Covid-19 Pandemic among 10th and 12th Standard Students
Authors: Thakare Isha , Sakharkar Sheetal , Udan Ankita , Telrandhe Vaishnavi , Tapase Saurabh 
Published: December 2021

The COVID-19 pandemic has had a major impact on school children especially in their academic performance which may affect their mental health. The College students bear more pressure and have more serious physical and mental health problems. Due to the recent social changes in the education domain (e.g., the sharing of educational resources and advances in communication technology), the use of distance education is more and more, which changes the communication patterns between teachers and students, increases the isolation and independence of students, and thus becomes an important source of pressure for students [1].
Aim of the Study: To assess the level of stress during COVID-19 pandemic among the students of 10th and 12th standard. 2. To associate the level of stress during COVID-19 pandemic among the students of 10th and 12th standard with demographic variables.
Methodology: An descriptive study will be use to assess the level of stress during COVID-19 pandemic among the 10th and 12th standard students in Wardha, Maharashtra. A purposive sampling technique will be use to pick the sample. A total 100 students who met the inclusion criteria will be select for this study. A Perceived Stress Scale was created to assess the stress.
Expected Results: This study is mainly planned to assess the level of stress in students of 10th and 12th standard with the help of Perceived Stress Scale and demographic variables.
Conclusion: Final conclusion will be drawn from final result of the statistical review.
Long COVID Syndrome Presenting as Hyperferritenemia Associated Toxic Encephalopathy in a Deferoxamine Compliant Patient of Beta Thalassemia
Authors: Patel Sujal , Talwar Dhruv , Kumar Sunil , Acharya Sourya , Patel Mansi 
Published: December 2021

Ferritin overload is a frequent problem encountered in patients with beta thalassemia amounting to various complications. One of rare but important complication of ferritin overload is ferritin overload induced toxic encephalopathy. Serum ferritin has been recognised as a important marker of inflammation and cytokine storm in COVID19.We present a case of Long COVID syndrome presenting as toxic encephalopathy in a case of beta thalassemia in spite of the patient being compliant to desferroxamine therapy.This report highlights the synergistic effect of Severe Acute Respiratory Syndrome Coronavirus. 2(SARS CoV 2) mediated neuroinflammation through direct viral invasion and the release of inflammatory cytokines including ferritin resulting in toxic encephalopathy in a beta thalassemia major patient who was already prone to develop hyperferritenemia.Ferritin functions as a pro-inflammatory cytokine and it’s level increases in both thalassemia and COVID-19 and the index case presented here had both the conditions predisoposing him to develop toxic encephalopathy even after being compliant to deferoxamine therapy. It is important to recognise and treat this condition in order to prevent mortality and morbidity in patients of beta thalassemia who contract COVID19.
Preventive Recommendations to Reduce the Impact of Poor Ergonomics on Children during Online Learning
Authors: Meshram Khushbu , Tembhare Vaishali , Taksande Archana , Pohekar Savita , Kasturkar Pooja , Sakharkar Sheetal , Wankhede Darshanakumari , Sakharwade Prerana 
Published: December 2021

The term 'ergonomics' and 'human factors' are interchangeable, 'ergonomics' is generally used in regard to physical features of the workplace, such as workstations and control panels, whilst 'human factors' is generally used in regard to the larger system in which people co-operate. This COVID 19 pandemic impact make the children to stay at home only and government of India has been supported the online education for the children and because of that change the whole learning system in India. While attending the classes at home mostly the parents don’t have that much knowledge regarding ergonomics to prevent the lot of physical as well as mental health problems, impact of poor ergonomics kids faced lot of problems like headache, back pain, knee pain, eye irritation etc as we called as repetitive strain injuries and musculoskeletal health has been deteriorated.
Conclusion: Parents and teachers do not appear to involve schoolchildren in conversations about safe computing behaviors, which might be due to their own lack of understanding of computer ergonomics and also the impact of COVID 19 Pandemic drastically affect the children’s schooling and have to learn at home through the online education system. Ergonomic education should also include into the school curriculum as future necessity.
Case Report on Sickle Cell Anaemia (SS Pattern)
Authors: Waghaye Mayur , Sakharkar Sheetal , Gujar Samrudhi , Morey Swapna , Dhengare Archana , Sakharwade Prerna , Kumari Darshana , Kasturkar Pooja , Naik Madhuri 
Published: December 2021

Sickle cell anemia is a kind of hemolytic anemia that is passed down in families. It is a kind of hemolytic anemia caused by inheriting the sickle hemoglobin gene. Africans, as well as individuals from the Middle East, the Mediterranean region, and India's aboriginal tribes, have a lower level of the sickle hemoglobin (HbS) gene. A kind of anemia that affects both children and adults is sickle cell anemia.
Clinical Finding: Since 5 days, A 25-year-old man has been experiencing generalized bodily pain and anxiety.
Examining the Problem: ALT (SGPT)- 97 U/L, AST (SGOT)- 56 U/L, total bilirubin – 5.4 mg percent, bilirubin conjugated – 1.7 mg percent, bilirubin unconjugated – 3.7 mg percent, total RBC count – 3.71 million/cu mm, total WBC count – 22100 cu mm, total platelets count – 6.46 lack/cu.
Ultrasonography: Heterogeneous spleen.
Therapeutic Intervention: Inj. Piptaz 4.5 gm TDS, inj. Levoflox 500 mg, tab. Hydroxyurea 500 mg, tab. Neurobion forte, inj. Pan 40 mg, inj. Tramadol 100 mg.
Outcome: The client's condition has improved as a result of the treatment. He has no longer generalized bodily aches, and his anxiety levels have decreased.
Conclusion: A 25-year-old man was admitted to Acharya Vinoba Bhave Hospital's Medicine ward with a history of sickle cell anaemia and complaints of nonspecific body aches and anxiousness. His condition improved after he received proper therapy.
Neuroimaging Assessment of Aggressive Pituitary Adenomas
Authors: Yusupovna Khalimova Zamira , Talatovna Azimova Ozoda 
Published: December 2021

Aggressive pituitary adenomas (APA) are adenomas that show rapid growth, invasiveness, frequent or multiple relapses, or are resistant to conventional therapies. Clinical-imaging assessment of aggressive pituitary adenomas with the aid of magnetic resonance imaging (MRI) plays an important role in early prediction, further disease outcomes and aggressive behavior of adenomas.
Purpose of the Study: was to assess the correlation of neuroimaging data with the hormonal activity of APA.
Materials and Methods: The study included 74 patients with aggressive pituitary adenomas. The average age of the patients was from 12 to 69. The patients underwent a basal assessment of the level of pituitary hormones: prolactin (PRL), GH (growth hormone), insulin-like growth factor-1 (IGF-1) and blood cortisol by the RIA method, as well as an MRI study. Knop's classification was used to assess the invasion.
Results: The hormonal workup showed prevalence of inactive pituitary adenomas among aggressive adenomas. No correlation was found between the hormonal activity of aggressive adenomas and the volume of pituitary adenomas. Moreover, MRI data indicated that invasion into the cavernous sinus of the III degree and heterogeneity of the adenoma may be considered equivalents of aggressiveness.
Conclusion: The established patterns support the need for visualization assessment of aggressive pituitary adenomas and strongly suggest the evaluation of the degree of aggression based on tumor heterogenecity, chiasm compression, hypo- and iso-intensity in T1 mode and hyperintensity in T2 modes.
A Case of Small Bowel Intimation with Sepsis
Authors: Sontakke Sanjana , Alwadkar Sagar , Wanjari Mayur 
Published: December 2021

Introduction: Sepsis is a life-threatening organ failure that occurs in severely ill patients as a result of a primary infectious cause or subsequent infection of injured tissues. The systemic effects of sepsis have been extensively studied, and evidence of local alterations and repercussions in the intestinal mucosal compartment is gradually characterizing sepsis-related changes in the gut. The current study focuses on sepsis-induced intestinal barrier failure, which includes increased epithelial permeability, which may allow bacterial translocation. The small bowel, commonly known as the small intestine, is roughly 1 inch in diameter and 20 to 30 feet long. It has a lot of folds to help it fit inside the abdominal cavity. The small bowel is connected to the stomach on one end and the big intestine on the other.
Patient information: He was 63 years old male admitted to Acharya Vinoba Bhave Rural hospital sawangi meghe Wardha in MICU ward with chief complaints of altering sensorium. Low urine output vomiting, loss of appetite, swelling of the abdomen crampy abdominal pain that comes and goes.
The Main Diagnosis, Therapeutic Intervention and Outcomes: A CT scan revealed a thicker transverse colon wall. His flexible sigmoidoscopy revealed “patchy inflammation and an isolated area of severe deep ulceration with nodularity and edema,” according to the report. The patient was given a preliminary diagnosis of "Inflammatory Bowel Disease—likely Crohn's," and was treated with steroids and Patient was done colonoscopy and course of inj. hydrocortisone, inj. Neomol, inj. levipril.
Conclusion: In the case of acute small-bowel obstruction, helical CT is a highly sensitive approach for diagnosing or ruling out intestinal ischemia. In patients with significant trauma who are being assessed for sepsis of unknown origin, abdominal computed tomographic scans accurately identify intra-abdominal foci of infection. This patient was diagnosed with small bowel intimation and sepsis.
Spectrum of Lesions in the Fallopian Tubes – A Histopathogical Study
Authors: Palani Maanasa , Harikrishnan Volga 
Published: December 2021

Introduction: The Fallopian tubes are a pair of narrow tubular structures connecting the ovary and the uterus. It is usually the site of fertilization and plays a very important role in the fusion of the sperm and ovary and helps in movement of the fertilized zygote to the uterus. Even though being an organ of very small size the importance of the variety of lesions occurring in the fallopian tubes is often not considered. Biopsies of the fallopian tubes are taken to show the different lesions found in the tubes.
Aim: The main aim of the study is to study the spectrum of lesions occurring in the fallopian tubes and correlation of these findings with its clinical parameters.
Study Design: This is a retrospective descriptive study
Place and Duration of Study: Department of Pathology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai between June 2019- December 2019.
Methodology: A retrospective study of all the fallopian tube specimens sent for routine histopathological analysis over a period of 6 months was carried out. The different pathological lesions were observed from the relevant clinical data and the correlation with its clinical parameters was done.
Results: A sample size of 77 specimens was collected among which the commonest age group which was found to have the highest number of lesions was between 26-30 years. This was found to be in correlation to the reproductive age group of women. The most common form of pathological lesion observed was ectopic pregnancy (about 46% of total pathological lesions), followed by Paratubal cysts (23%), Hydrosalpinx (15%) and Hematosalpinx (8%). Cystadenoma was the only benign tumor observed in this study and constituted 8% of the total pathological lesions.
Conclusion: This study shows the importance of histopathological examination of all fallopian tube specimens with or without abnormal findings.
Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing
Authors: Mitila T. , Subramanian P. S. Muthu , Srinivasan Chitra , Chander Vimal 
Published: December 2021

Background: Globally, breast cancer contributes to 27.7% of the newly diagnosed cases of cancer among women. Early screening and timely diagnosis of the lesions of breast help in alleviating the anxiety among patients. Histopathology is the gold standard in diagnosing the lesions, assessing the adequacy of treatment, and in disease prognosis. Studies have shown that ABO blood type has been associated with risk and survival for several malignancies. However, data for an association with breast cancer are inconsistent.
Aim: To study the histopathological spectrum breast carcinomas and to investigate the presence of a possible association between breast cancer in women and ABO blood group and Rh factor.
Materials and Methods: This retrospective descriptive study was done for a period of 4 years on 110 mastectomy specimens histopathologically diagnosed as breast cancers, and clinico-pathological data collected and analysed with records from the Department of Pathology, Saveetha Medical College. Association of breast cancer with ABO blood grouping and Rh typing was studied.
Results: Left breast was involved in most cases (96.4%). The mean age was 50.86 years, with 41-50 years age group showing peak incidence. Infiltrating breast carcinoma, no special type (89.6%) was the most common histological type. ER and PR positivity was seen in 46.4% and 41.8% of cases respectively. A statistically significant association was seen between hormone receptor status and histological grade. 39.1% cases belonged to O blood group, and Rh positivity was seen in 96.4% of the cases. No association was found between breast cancer and ABO/Rh blood grouping.
Measurement of Plasma Fibrinogen Levels, PT and APTT among HIV Infected Patients: A Critical Bio-Marker for Coagulation Dysfunctions
Authors: Ahmed Allageya Yousif Khailfa , Gaufri Nasr Eldeen Ali Mohammed , Abdelgani Sara , Eltayeb Lienda Bashier 
Published: December 2021

Background: The literature stated that Human immunodeficiency virus (HIV) infection led to activation of coagulation, and habitually linked with an augmented risk of venous and arterial thrombosis. So the purpose of the study was to determine the plasma fibrinogen level in Sudanese HIV-infected patients.
Materials and Methods: A total of one hundred participants were recruited, and classified into two groups; the case group include (50) HIV patients, and the control group enrolled (50) healthy individuals. Three ml of blood was collected. Fresh Poor Plasma was prepared from citrated venous blood by centrifuged for 15 minutes at 3000 pm. Fibrinogen levels were measured by an automated coagulation analyzer (Thrombolyzer XRC Germany). Data were collected using a directly structured questionnaire. Data were analyzed using SPSS Version 21.
Results: The present study showed that the mean of plasma fibrinogen levels was statistically significantly higher in HIV infection in comparison with those normal healthy control (470.50 ±67.75 vs 214.75±21.25 with P-value 0.00). There was a significantly decreased level of PT, and PTT among the HIV group comparing with the control (9.575±0.64, and 22.39±4.94) VS (12.483±0.72, and 30.78±3.55) consequently, (P-value ≤0.001). Fibrinogen levels were significantly increased with the progression of HIV disease (469.84 ±67.15, 472.74 ±87.75, 478.47 ±61.92) in stage I, stage II, and stage III respectively.
Conclusions: An HIV-infected patient had elevated plasma fibrinogen levels, as well as other coagulation dysfunctions.
Comparison of NS1 Antigen Detection by Rapid Immunochromatography Test and ELISA for Early Diagnosis of Dengue at a Government General Hospital, Ananthapuramu
Authors: Naidu Adireddi Paradesi , Saikumar Chitralekha , Sumathi G. , Victor Kalavathy , Muthiah N. S. 
Published: December 2021

Background: The incidence of Dengue hemorrhagic fever, Dengue shock syndrome associated with Dengue can be reduced by diagnosing Dengue early and by initiating early treatment to Dengue patients. This study was conducted to compare results of NS1 antigen rapid test and ELISA in clinically suspected dengue patients.
Materials and Methods: Present study was a comparative study conducted on 100 Patients presented with clinical history of Dengue. At Microbiology Laboratory, serum of all samples was assessed for NS1 detection using antigen Rapid test and ELISA. Sensitivity & specificity values were calculated for NS1 antigen rapid test, compared with ELISA.
Results: Out of 100 serum samples collected from suspected cases of Dengue in and around Anantapuramu, 30 (30%) were positive for ELISA and 28 (28%) were positive for Rapid diagnostic test. Sensitivity & specificity when only NS1 was considered on rapid test kits when compared with ELISA were 93.33%, 98.57%,
Conclusion: It is concluded that ELISA test was superior in the diagnosis of Dengue and recommended on improvement in sensitivity of RDTs.