bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Intradialytic Group Exercise Influence Malnutrition and Quality of Life in Maintenance Hemodialysis Patients? Evidence From an Experimental Study Using a Single-group Repeated-measures Design
Authors: Zhou Li-Juan , Zhang Li-Yuan , Shi Dan , Wang Qian , Chen Li 
Published: November 2021

Abstract
BackgroundMaintenance hemodialysis (MHD) patients is the representative of the sedentary group and often suffer from physical inactivity. Exercise rehabilitation is not widely included in dialysis care despite demonstrated health benefits. This study aimed to evaluate the effectiveness of intradialytic group exercise in MHD patients.MethodsThis was a single center, single-group repeated-measures design study, which included MHD patients in the hemodialysis center in Taizhou, China. The 12-week, 3 times per week intradialytic group exercise programme was conducted around 30 min during the first 2 hours of each dialysis session. Anthropometric indicators, including Body Mass Index (BMI), Triceps Skinfold Thickness (TSF), Mid-upper Arm Circumference (MUAC), Mid-arm Muscle Circumference (MAMC) Handgrip Strength (HGS), and quality of life were measured at baseline, 4-week follow up and 12-week follow up. Laboratory indicators, including Hemoglobin level (Hb), Total Protein (TP) and Albumin (Alb) were measured at baseline and 12-week follow up. The repeated-measures analysis of variance and Friedman test were used to compare the parametric and non‐parametric data at three time points, respectively. Paired t test was used to compare the continuous parametric between two time points.ResultsNinety patients were enrolled at baseline and seventy-five patients finished the whole 12-week exercise programme. There were 7 patients dropped out for losing of motivation and sample churn rate for losing of motivation was 7.8% (7/90). Participants reported significant improvements in most of the outcomes, TSF (F (2, 148) = 28.908, p = 0.000), MUMC (F (2, 148) = 3.1821, p = 0.044), MAMC (F (2, 148) = 27.795, p = 0.000), HGS (F (2, 148) = 42.383, p = 0.000), TP (F (t = -2.417, p = 0.018), ALB (t -3.190, p = 0.002), Hb (t = -2.353, p = 0.021), and QOL (F (2, 148) = 10.48, p = 0.000).ConclusionsThe positive results from this research suggest that intradialytic group exercise programme including aerobic exercise and resistance exercise is a safe and suitable exercise way for maintenance hemodialysis patients. This exercise can help keep patients’ motivation and improve nutritional status and quality of life in maintenance hemodialysis patients.
Living material assembly of bacteriogenic protocells
Authors: Xu Can , Martin Nicolas , Li Mei , Mann Stephen 
Published: November 2021

Abstract
Advancing the spontaneous bottom-up construction of artificial cells with high organisational complexity and diverse functionality remains an unresolved issue at the interface between living and non-living matter. To address this challenge, a living material assembly process based on the capture and on-site processing of spatially segregated bacterial colonies within individual coacervate micro-droplets is developed for the endogenous construction of membrane-bounded, molecularly crowded, compositionally, structurally and morphologically complex synthetic cells. The bacteriogenic protocells inherit diverse biological components, exhibit multi-functional cytomimetic properties and can be endogenously remodelled to include a spatially partitioned DNA/histone nucleus-like condensate, membranized water vacuoles and a self-supporting 3D network of F-actin proto-cytoskeletal filaments. The ensemble is biochemically energized by self-sustainable ATP production derived from implanted live E. coli cells to produce a cellular bionic system with amoeba-like external morphology and integrated life-like properties. Our results demonstrate a novel bacteriogenic strategy for the bottom-up construction of functional protoliving micro-devices and provide opportunities for the fabrication of new synthetic cell modules and augmented living/synthetic cell constructs with potential applications in engineered synthetic biology and biotechnology.
Effect of Placing Double-lumen Irrigation-suction Tube on Spontaneous Closure of Anastomotic Leakage Following Rectal Cancer Surgery
Authors: Tian Weliang , Huang Ming , Xu Xin , Yao Zheng , Zhao Risheng 
Published: November 2021

Abstract
Purpose: This study aimed to explore the effect of placement of double-lumen irrigation-suction tubes (DLIST) on the spontaneous closure of anastomotic leakages (AL) after rectal cancer surgery. Methods: The study was performed at two centers which was managed by the same chief. The treatment in the two center were same. From January 2011 to June 2020, patients with postoperative AL after rectal cancer surgery were eligible. Patients were divided into a passive drainage (PD) group and a DLIST group according to whether the PD,placed during the rectal cancer surgery, had been replaced with the DLIST. The effect of DLIST on the AL was evaluated.Result: There were 76 patients in the DLIST group and 52 in the PD group. The DLIST group was more inclined to achieve spontaneous closure of AL (HR =3.048; 95% CI: 1.787-5.197; P<0.001). Both length of stay and costs of the treatment in the DLIST group were lower (54 [41.25-117] days vs. 112 [66.75-127.75] days, P =0.005; and $18,721 [$14,982-44,960] vs. $40,840 [$20,932-50,529], P < 0.001).Conclusion: Placement of DLIST is an effective method for treating AL following rectal cancer surgery. Compared with PD, the cost of DLIST in the treatment of AL is lower and the length of stay is shorter.
Targeting PD-L1 and TIGIT Could Restore Intratumoral CD8 T Cell Function in Human Colorectal Cancer
Authors: Thibaudin Marion , Limagne Emeric , Hampe Léa , Ballot Elise , Truntzer Caroline , Ghiringhelli François 
Published: November 2021

Abstract
Microsatellite stable colorectal cancers (MSS-CRC) are resistant to anti-PD-1/PD-L1 therapy but the combination of immune checkpoints inhibitors (ICI) could be a clue to reverse resistance. Our aim was to evaluate ex vivo the capacity of the combination of atezolizumab (anti-PD-L1) and tiragolumab (anti-TIGIT) to reactivate the immune response of tumor infiltrating lymphocytes (TILs) in MSS-CRC. We analysed CRC tumor tissue and the associated blood sample in parallel. For each patient sample, extensive immunomonitoring and cytokine production were tested. We generated an ex vivo assay to study immune reactivity following immune stimulation with checkpoint inhibitors of tumor cell suspensions. Three microsatellite instable (MSI) and 13 MSS-CRC tumors were analysed. To generalize our observations, bioinformatics analyses were performed on public data of single cell RNA sequencing of CRC TILs and RNA sequencing data of TCGA. Atezolizumab alone could only reactivate T cells from MSI tumors. Atezolizumab and tiragolumab reactivated T cells in 46% of MSS-CRC samples. Reactivation by ICK was observed in patients with higher baseline frequency of Th1 and Tc1 cells, and was also associated with higher baseline T cell polyfunctionality and higher CD96 expression. CD96 expression was found in CD4 and CD8 TILs and was highly expressed in exhausted T cells. CD96 was expressed at higher levels in CMS1 and CMS4 tumors, and was related to intrinsic poor prognosis. Together these data suggest that the association of atezolizumab and tiragolumab could restore function of CD4 and CD8 TILs in MSS-CRC.
Treatment Outcome and Associated Factors among Type 1 Diabetic Children&lt;15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study
Authors: Meseret Fentahun 
Published: November 2021

Abstract
Background: Length of hospital stay and overall in hospital mortality of diabetic keto acidosis during management are the foremost primary out comes that should be measured. Because, it is highly trusted on the improvement of diabetic keto acidosis related complication management. However, data associated to length of stay, mortality rate due to diabetic keto acidosis remains to be limited in Ethiopia.In addition to this, Nonfiction is much scarce in relation to factors associated with treatment outcome starting from its initial presentation and the overall management process. Objective: To assess treatment outcome of children<15 years old admitted with diabetic keto acidosis at Felege Hiwot comprehensive referral hospital, North West, Ethiopia, 2021Methods: Retrospective cross sectional study was conducted at Felege Hiwot comprehensive referral hospital among randomly selected sample of 176 children admitted with diabetic keto acidosis from 2016 to 2021.Data were collected by using data abstraction tool. Then it was coded, enter, cleaned and stored into Epi-data version 4.2 and was exported into STATA 14.0 statistical software for analysis. Categorical variables were described using proportions and compared using Chi-square test; whereas continuous parametric variables with mean and standard deviation and compared using parametric (t-test). Model goodness-of-fit and assumptions were checked. Finally, association between independent variables and length of hospital stay were assessed using binary logistics regression and Variables with p-value < 0.05 were considered as statistically significant.Result: The mean length of hospital stay was 9.5±6.2 days. About 59.3% of had long hospital stay (>7days).Majority of the clients (97.5%) were improve and discharged with 14.2% management complication and 4(2.5%) died in the hospital. Factors that affect long hospital stay were residence(AOR=4.31;95CI=1.25-14.80),family history of diabetes (AOR=0.12; 95%CI=0.02-0.64),glycaemia at admission (AOR=1.01;95%CI=1.00-1.02),insulin skipping (AOR=0.08;95%CI=0.01-0.98),abdominal pain(AOR=4.28;95%CI=1.11 -15.52), time in which the patient get out of diabetic keto acidosis(AOR=6.39;95%CI=1.09-37.50).Conclusion and Recommendation: Majority of clients were showed improvement and discharged to their home after longer hospital stay and with very low mortality rate followed by complication (14.2%).The time with in which the majority of the clients get out of DKA were found in between 24-48 hours. Thus, to achieve the intended treatment out come early in time, modification of the approach by emphasizing the above predictors is mandatory with the recommendation of multicenter study in this regard.
Surgery Goes EPA (Entrusted Professional Activity) – How a Strikingly Easy to use App Revolutionizes Assessments of Clinical Skills in Surgical Training
Authors: Diwersi Nadine , Gass Jörn-Markus , Fischer Henning , Metzger Jürg , Knobe Matthias , Marty Adrian 
Published: November 2021

Abstract
ObjectiveEntrusted Professional Activities (EPAs) are increasingly being used in competency-based medical education approaches. A general lack of time in clinical settings, however, prevents supervisors from providing their trainees with adequate feedback. With a willingness for more administrative tasks being low in both trainees and educators, the authors developed a radical user-friendly mobile application based on the EPA concept called “Surg-prEPAred”.DesignSurg-prEPAred is designed to collect micro-assessment data for building competency profiles for surgical residents according to their curriculum. The goal of Surg-prEPAred is to facilitate the performance and documentation of workplace-based assessments. Through aggregated data the app generates a personalized competency profile for every trainee. During a pilot run of 4 months, followed by ongoing usage of the application with a total duration of 9 months (August 2019 to April 2020), 32 residents and 33 consultants made daily use of the application as a rating tool. Every rating included knowledge, skills and professional attitudes of the trainees. Before the initiation of the App and after the 9-month trial period trainees and supervisors where both sent questionnaires to evaluate the user friendliness and effectiveness of the App. Results510 App based assessments were generated. Out of 40 pre-defined EPAs, 36 were assessed. 15 trainees and 16 supervisors returned the questionnaires and stated the surg-prEPAred App as very valuable, effective and feasible to evaluate trainees in a clinical setting providing residents with an individual competence portfolio to receive precision medical education. ConclusionsThe authors expectation is that the Surg-prEPAred App will contribute to an improvement of quality of medical education and thus to the quality of patient care and safety. In the future the goal is to have the App become an integral part of the official Swiss surgical curriculum accepted by the Swiss professional surgical society.
A Cross-sectional Survey of Urban and Rural Residents' Perceptions About the Medical System Services in a Middle Province of China
Authors: Pan Ying , Li Shaowen , Yan Lina , Chen Sihua , Pi Kejiang , Xi Biao 
Published: November 2021

Abstract
Background: To investigate urban and rural residents' perceptions on the issue of "difficult access to quality medical services and expensive medical bills" (difficult and expensive medical services) 10 years after the implementation of medical and health care system reform in China.Methods: we conducted a cross-sectional questionnaire survey of residents in a middle province of China. Multi-stage stratified random sampling was utilized to sample a total of 1968 residents of three cities in the middle province in July 2019. Results: Residents in the province were highly satisfied with the solution of "difficult and expensive medical services", with the satisfaction rate reaching 70%. However, satisfaction differed among the surveyed cities. 83.4% of the residents reported "difficult and expensive medical services"as their current major concern. Complex medical procedures (31.25%) and high inspection costs (51.68%) were the main reasons for "difficult and expensive medical services". Other reasons include the provision of medical and health resources, the service awareness of medical and health care personnel, people's health needs, and the perceptions of health, etc. Conclusions: The issue of "difficult and expensive medical services" is a social issue requiring constant attention.
Correlation of CD4+CD57+, CD8+CD57+, CD4+KLRG1+, CD8+KLRG1+ T Cells Percentage and Serum MMP-9 Level with Cognitive Dysfunction among Systemic Lupus Erythematosus Patients
Authors: Pratama Mirza Zaka , Wahono Cesarius Singgih , Krisna Pratista Adi , Handono Kusworini , Kalim Handono 
Published: November 2021

Background: â€˜Lupus brain fogâ€™ is a phenomenon of cognitive function decline in SLE patients. Premature immunosenescence in SLE was presumed to play a significant role in the mechanism of cognitive dysfunction. Aim: To prove the correlation between the terminally-differentiated CD4+CD57+, CD8+CD57+, CD4+KLRG1+, and CD8+KLRG1+ T cells & serum levels of MMP-9 with cognitive dysfunction in SLE patients. Methods: 53 women SLE were conducted to perform MMSE and MoCA-Ina tests to evaluate cognitive function. Immunosenescence was observed by measuring the terminallydifferentiated CD4+CD57+, CD8+CD57+, CD4+KLRG1+, and CD8+KLRG1+ T cells, which were measured by flowcytometry. In addition, MMP-9, an enzyme produced by terminallydifferentiated T cells, was measured using ELISA. Results: SLE patients with cognitive dysfunction based on MMSE and MoCA-Ina test had higher percentage of CD4+CD57+, CD8+CD57+, CD4+KLRG1+, CD8+KLRG1+ T cells and serum levels ofÂ MMP-9 compared to patients with normal cognitive function. CD4+CD57+, CD8+CD57+, CD4+KLRG1+, CD8+KLRG1+Â T cells percentage and serum MMP-9 level showed negative correlation with both MMSE scores (r = -0.286; r = -0.447; r = -0.279; r = -0.537; r = 0,411) and MoCA-Ina scores (r = -0.454; r = -0.539; r = -0.435; r = -0.535; r = -0.648). Meanwhile, percentage of CD4+CD57+, CD8+CD57+, CD4+KLRG1+ and CD8+KLRG1+ T cells showed positive correlation with serum MMP-9 level (r = 0.292; r = 0.414; r = 0.449; r = 0.374). Conclusion:Â Expansion of CD4+CD57+, CD8+C57+, CD4+KLRG1+, CD8+KLRG1+ terminally differentiated T cells & increase of serum MMP-9 level are correlated with cognitive dysfunction in SLE patients
Manufacturing of fiber-reinforced concrete bridge arches
Authors: Nakhaev M. R. 
Published: November 2021

Objective. A new method of manufacturing arches for a fiber-reinforced concrete bridge in the form of an analogue of permanent formwork is considered. Within the framework of this work, research results have been obtained that confirm the effectiveness of the system for the construction of bridge arches of various configurations.Method. The proposed developments will improve the strength characteristics of the bridge arch for small and medium bridges by optimizing the shape and size of the cross section in accordance with the change in the bending moment along the length of the arch. At the same time, reduce its metal consumption by several times.Result. The results obtained confirmed the effectiveness of electrostatic spraying of dry concrete mixture with simultaneous moisture up to moisture, which contributes to the work of capillary forces for compaction of concrete layers and the manufacture of a profiled strong shell (analogue of non-removable reinforced formwork) from reinforced fiber-reinforced concrete.Conclusion. By varying the shape and dimensions of the cross- section, the thickness of the shell and the degree of its reinforcement, as well as filling this shell with high-strength fiber-reinforced concrete, it is possible to design and manufacture bridge arches for various loads.
PENGALAMAN PELANGGAN, REFERENCE GROUP, PERSEPSI HARGA DALAM KEPUTUSAN PEMBELIAN PRODUK ETNIK FASHION
Authors: Wibowo Alfi Fajria , Wulandari Jeni , Nugeraha Prasetya 
Published: November 2021

This study aimed to determine the effect of customer experience, reference group and price perception on consumer purchasing decisions at fashion ethnic product. The population in this study was the consumers of Juragan Kain Boutique. The data were obtained from questionnaires that were filled in online using a likert scale; the sampling technique used purposive sampling with total sample of 100 respondents of Juragan Kain Boutique consumers. The data analysis in this study used descriptive data analysis and multiple linear regression analysis. The results of this study indicated that customer experience; reference group and price perception partially and simultaneously had positive and significant effect on purchasing decision. In this study, price suitability with product quality was the dominant factor in price perception, because it determined the purchasing decision of the Juragan Kain boutique as an ethnic fashion product.
Abstrak
Penelitian ini bertujuan untuk mengetahui adakah pengaruh pengalaman pelanggan, reference group dan persepsi harga terhadap keputusan pembelian konsumen Butik Juragan Kain. Populasi dalam penelitian ini adalah konsumen Butik Juragan Kain. Data tersebut diperoleh dari kuisioner yang diisi secara online dengan menggunakan skala likert, teknik pengambilan sampel menggunakan purposive sampling dengan jumlah sampel sebanyak 100 responden konsumen Butik Juragan Kain. Analisis data dalam penelitian ini menggunakan analisis data deskriptif dan analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa pengalaman pelanggan, reference group dan persepsi harga, secara parsial dan simultan berpengaruh positif dan signifikan terhadap keputusan pembelian. Pada penelitian ini kesesuaian harga dengan kualitas produk menjadi faktor dominan dari persepsi harga, karena menentukan keputusan pembelian Butik Juragan Kain sebagai produk ethnic fashion.
IMPLEMENTASI PUBLIC RELATION PADA KLINIK TERAPI RUQYAH SYAR’IYYAH DPW QHI LAMPUNG SEBAGAI RESPON ATAS MENINGKATNYA TREND HALAL LIFE STYLE
Authors: Anissa Anissa , S Arif Sugiono , Saptiana Fenny 
Published: November 2021

This study aims to determine the implementation of public relations in the therapy clinic ruqyah syar'iyyah DPW QHI Lampung. This study uses a descriptive method with a qualitative approach. In this study, the researchers obtained the results that the implications of public relations in the treatment clinic of ruqyah syar'iyyah DPW QHI Lampung consisted of publications, events or events, community service activities and media identity.
ABSTRAK
Penelitian bertujuan untuk mengetahui implementasi public relation pada klinik terapi ruqyah syar’iyyah DPW QHI Lampung. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Dalam penelitian ini peneliti memperoleh hasil bahwa implikasi public relation pada klinik terapi ruqyah syar’iyyah DPW QHI Lampung terdiri dari publikasi, peristiwa atau acara, kegiatan pelayanan masyarakat dan media identitas.
PENGARUH TOTAL ASSET TURNOVER, DEBT TO EQUITY RATIO (DER), UKURAN PERUSAHAAN, NILAI TUKAR RUPIAH, DAN IHSG TERHADAP TERJADINYA TINGKAT UNDERPRICING SAHAM
Authors: Renitia Renitia , Suripto Suripto , Harori M. Iqbal Iqbal 
Published: November 2021

This study aims to determine the influence of total asset turnover, debt to equity ratio (DER), company size, rupiah exchange rate and IHSG on the occurrence of stock underpricing levels. The population used is companies that conduct IPO (Initial Public Offering) on the Indonesia Stock Exchange period 2015-2019, the population of 177 companies and samples in this study are 133 companies determined through purposive sampling. The data analysis techniques used are multiple linear regression analysis and hypothesis test with t-test and F-test. Based on the hypothetical test results showed that partial variable total asset turnover and the size of the company had a significant effect on the occurrence of stock underpricing, while other variables namely debt to equity ratio, rupiah exchange rate and IHSG were not shown to have a significant effect on the occurrence of stock underpricing. F test results showed that total asset turnover, debt to equity ratio (DER), company size, rupiah exchange rate, and JCI simultaneously had a significant effect on the level of stock underpricing.
ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh total asset turnover, debt to equity ratio (DER), ukuran perusahaan, nilai tukar rupiah dan IHSG terhadap terjadinya tingkat underpricing saham. Populasi yang digunakan adalah perusahaan yang melakukan IPO (Initial Public Offering) di Bursa Efek Indonesia selama tahun 2015-2019, populasi sebanyak 177 perusahaan dan sampel dalam penelitian ini adalah 133 perusahaan yang ditentukan melalui purposive sampling. Teknik analisis data yang digunakan adalah analisis regresi linier berganda dan pengujian hipotesis serta uji asumsi klasik yang meliputi uji normalitas, uji multikolinearitas, uji heteroskedastisitas dan uji autokorelasi dengan tingkat signifikansi alpha 5%. Berdasarkan hasil uji hipotesis menunjukkan bahwa secara parsial variabel total asset turnover dan ukuran perusahaan berpengaruh signifikan terhadap terjadinya underpricing saham, sedangkan variabel lain yaitu debt to equity ratio, nilai tukar rupiah dan IHSG tidak terbukti berpengaruh signifikan terhadap terjadinya underpricing saham. Hasil uji F menunjukkan bahwa total asset turnover, debt to equity ratio (DER), ukuran perusahaan, nilai tukar rupiah, dan IHSG secara simultan berpengaruh signifikan terhadap tingkat underpricing saham.