bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ovarian Cysts Classification Using Novel Deep Q-Learning With Harris Hawks Optimization Method
Authors: C Narmatha , P Manimegalai , J Krishnadass , Valsalan Prajoona , S Manimurugan 
Published: September 2021

Abstract
This research presents an essential solution for classifying ultrasound diagnostic images describing seven types of ovarian cysts: Follicular cyst, Hemorrhagic cyst, Corpus luteum cyst, Polycystic-appearing ovary, endometriosis cysts, Dermoid cyst, and Teratoma. This work proposed a novel technique using images of ovarian ultrasound cysts from an ongoing database with this motivation. Initially, the work is followed by removing noise in preprocessing, feature extraction, and finally classifying using new Deep Q-Network with Harris Hawks Optimization (HHO) classifier. Automatic feature extraction is implemented using the recent popular convolutional neural network (CNN) technique that extracts image features as conditions in the reinforcement learning algorithm. With this, through the procedure of a new deep Q-learning algorithm, Deep Q-Network (DQN) is generated to train a Q-network. The swarm-based method of HHO utilized the optimization method to produce optimal hyperparameters in the DQN model known as HHO-DQN, a novel technique for classifying ovarian cysts. Extensive experimental evaluations on datasets show that the proposed HHO- DQN approach outperforms existing active learning approaches for ovarian cyst classification. Compared with the ANN, CNN, and AlexNet models, the performance of the proposed model is better in terms of precision, f-measure, recall, accuracy, and IoU. The proposed model has achieved 96% precision, 96.5% f-measure, 96% recall, 97% accuracy, and 0.65 IoU.
The Effects of Medium-to-Low Dose Glucocorticoids on Glucose Profiles in Patients with Interstitial Pneumonia with Autoimmune Features (IPAF) Evaluated by Continuous Glucose Monitoring System (CGMS): An Observational Study
Authors: Li Jiapei , Shi Juhong , Dong Yingyue , Yuan Tao , Fu Yong , Xu Tao , Zhao Weigang 
Published: September 2021

Abstract
Background: Few studies focused on the effects of medium-to-low dose glucocorticoids on glucose profiles and glucose metabolism in patients with interstitial pneumonia with autoimmune features (IPAF). Continuous glucose monitoring system (CGMS) can provide more detailed glucose features than fingertip blood samplings.Methods: This was a observational study in a teaching hospital. Outpatients with IPAF on 15mg prednisone per day for at least 3 months were recruited to receive CGMS and blood tests. The primary data of CGMS were analyzed to demonstrate the glucose features. Data were compared between subjects with a glucocorticoid treatment duration of more than 2 years(Group 1) and subjects with that of less than 2 years(Group 2). In subgroup analysis, among all subjects, subjects who tapered the daily dose to 7.5mg for at least 3 months received second tests. Results: 93% (27/29) on daily 15mg prednisone and all subjects on daily 7.5mg prednisone were with glucocorticoid induced hyperglycemia(GIH). Among subjects on daily 15mg prednisone, glucose AUC of 3 hours post-lunch was significantly higher than those post-breakfast and post-dinner, and mean glucose levels of half an hour pre-lunch and pre-dinner were significantly higher than that pre-breakfast. 81.9% of nocturnal glucose nadirs presented after 5AM, leading to relatively low fasting glucose values. There were no significant differences of glucose profiles between Group 1 and Group 2. No significant differences of CGMS and laboratory parameters were found between on daily 15mg prednisone and on daily 7.5mg prednisone.Conclusions: A large proportion of outpatients on medium-to-low-dose glucocorticoids are with GIH. Post-lunch glucose or post-dinner glucose are good indicators, while fasting glucose is not. The similar glycemic effects of daily 15mg and 7.5mg prednisone provide evidence for physicians to choose long-term maintaining glucocorticoid dose.Clinical Research Registration: This research is registered at clinicaltrials.gov(No.NCT02824757) with the registry named The Effects of Glucocorticoids on Glucose Metabolism in Patients With Interstitial Lung Disease. The URL is https://clinicaltrials.gov/ct2/show/NCT02824757?term=NCT02824757&draw=2&rank=1.This research is registered at July 7th,2016, retrospectively.
Investigating how the accuracy of teacher expectations of pupil performance relate to socioeconomic and genetic factors
Authors: Barry Ciarrah-Jane , Davies Neil , Morris Tim 
Published: September 2021

Abstract
Teacher expectations of pupil ability can influence pupil’s educational progression, impacting subsequent streaming and exam level entry. Systematic errors in the accuracy of teacher expectations of pupil achievement may therefore have a lasting detrimental effect on a child’s education and life prospects. Associations between socioeconomic and demographic factors with teacher expectation accuracy have been previously investigated, but it is not known how expectation accuracy may relate to genetic factors. We investigated these relationships using data on nationally standardized exam results at ages 11 and 14 from a UK longitudinal cohort study. We found that teacher expectation of achievement was strongly correlated with subsequent achievement, that teacher expectation accuracy was patterned by pupil socioeconomic background but not teacher characteristics, and that teacher expectation accuracy related to pupil’s genetic liability to education. We find no strong evidence for heritability in teacher reporting accuracy, suggesting that the majority of variation in teacher expectation accuracy can be attributed to non-genetic factors.
Tailoring Dissemination of Evidence to Preferences of Tobacco Control Partners: Results From an Academic-community Partnership
Authors: Mckay Virginia , Vogel Mia , Combs Todd , Brossart Laura , Endrizal Amy , Andersen Stephanie , Poor Timothy , Mahoney Margaret , Luke Douglas 
Published: September 2021

Abstract
BackgroundTobacco control program leaders and their partners, who often present evidence to policymakers, can increase the use of evidence in program and policy development. However, up-to-date, evidence-based information from the scientific community about what works is slow to reach leaders. We describe efforts to understand and utilize tobacco control leaders’ preferences for receiving evidence and report on resulting dissemination strategies, translational products and outcomes.MethodsThis work is part of the Advancing Science and Practice in the Retail Environment (ASPiRE) Center, an interdisciplinary research center focused on understanding and evaluating tobacco retail policy. Participants were members of the ASPiRE Community Advisory Board (CAB), comprised of tobacco control leaders from 30 metropolitan areas representing all regions of the US plus nine representatives from leading national tobacco control organizations (N=39). During meetings in February 2019 and October 2020, all CAB members were invited to participate in live polls consisting of six survey questions each. Questions addressed preferences for receiving scientific evidence and their anticipated use of ASPiRE translational products. Responses were analyzed descriptively and informed translational product development and communications with ASPiRE contact list members (N»125). ASPiRE email and website interactions were tracked from March 2019 to May 2021 as a complementary indication of content use.ResultsResponse rates for 2019 and 2020 CAB meetings were 66% (n=26) and 59% (n=23), respectively. CAB members indicated preferences for email communication (33%) and webinars (31%), communications once per month (46%), and short-format documents (28%). In response, the team developed translational short-format products including case studies, fact sheets, and research briefs. On average, 52% (SD=14%) of recipients opened the newsletter and 17% (SD=9%) clicked a link within the newsletter. Overall, 95% of responding CAB members found the products useful and all responding CAB members reported using them to communicate evidence to policymakers, staff, and coalition members. ConclusionsOur successful dissemination approach to making evidence more accessible and useable for tobacco control leaders could be adapted by researchers working with community partners to assess and respond to stakeholders’ preferences for receiving evidence in other areas of health policy.
Boron Neutron Capture Therapy and Add-on Bevacizumab in Patients with Recurrent Malignant Glioma
Authors: Furuse Motomasa , Kawabata Shinji , Wanibuchi Masahiko , Shiba Hiroyuki , Takeuchi Koji , Kondo Natsuko , Tanaka Hiroki , Sakurai Yoshinori , Suzuki Minoru , Ono Koji , Miyatake Shin-Ichi 
Published: September 2021

Abstract
Introduction: Boron neutron capture therapy (BNCT) has shown excellent survival data but increases in radiation necrosis against recurrent malignant glioma (MG) in previous studies. We proposed that bevacizumab may reduce radiation injury from BNCT by re-irradiation. We evaluated the efficacy and safety of a combination therapy of BNCT and add-on bevacizumab in patients with recurrent MG.Methods: Patients with recurrent MG were treated with reactor-based BNCT. Treatment with bevacizumab (10 mg/kg) was initiated 1–4 weeks after BNCT irradiation and was re-administered every 2–3 weeks until disease progression. Initially diagnosed glioblastomas were categorized as primary glioblastoma (pGBM) and other forms of MG were categorized as non-pGBM. Results: Twenty-five patients (14 with pGBM and 11 with non-pGBM) were treated with BNCT and add-on bevacizumab. The 1-year survival rate for pGBM and non-pGBM was 63.5% (95% CI, 33.1–83.0) and 81.8% (95%CI, 44.7–95.1), respectively. The median OS was 21.4 months (95% CI, 7.0–36.7) and 73.6 months (95% CI, 11.4–77.2) for pGBM and non-pGBM, respectively (p = 0.0428). The median PFS was 8.3 months (95%CI, 4.2–12.1) and 15.6 months (95% CI, 3.1–29.8) for pGBM and non-pGBM, respectively (p = 0.0207). Alopecia occurred in all patients. Six patients experienced adverse events ≥ grade 3.Conclusions: BNCT and add-on bevacizumab were found to provide both a long OS and a long PFS, compared to the previous studies of BNCT alone for recurrent MG. The add-on bevacizumab may reduce the detrimental effects of BNCT radiation, including pseudoprogression and radiation necrosis.
Mudanças de Hábitos e Rotinas nos Controles de Gestão Provocadas pelo Sped em um Grupo Empresarial do Sul do Brasil
Authors: Almeida Dalci Mendes , Gasparetto Valdirene , Schnorrenberger Darci 
Published: September 2021

A pesquisa objetiva verificar as mudanças de hábitos e rotinas que ocorreram nos controles de gestão a partir da implantação do Sistema Público de Escrituração Digital (SPED), sob a abordagem institucional, em um grupo empresarial do sul do Brasil. O pressuposto teórico é de que as empresas para atenderem ao SPED tiveram que mudar seus hábitos e rotinas em termos de controles de gestão. Para tanto, desenvolveu-se um estudo de caso, em um grupo empresarial formado por seis empresas. O instrumento de pesquisa utilizado foi um roteiro de entrevista. Como coleta de dados utilizou-se a entrevista, análise documental e observação. Os achados apontaram que a implantação do SPED gerou necessidades de investimentos em recursos humanos e tecnológicos, trouxe benefícios, dificuldades e acarretou em mudanças nos controles de gestão em aspectos como eficiência, informações geradas, frequência de utilização, investimentos em tecnologia da informação e recursos humanos que os geram. A pesquisa contribuiu no sentido de evidenciar que o SPED exigiu maior organização, planejamento e controle das operações, o que permitiu proporcionar controles mais eficientes e que possam ser utilizados no processo de gestão de forma segura. Conclui-se, com base nas análises realizadas, que as mudanças de hábitos e rotinas nos controles de gestão, provocadas pelo SPED, resultaram na institucionalização de novas regras e rotinas nos moldes preconizados por Burns e Scapens (2000).
Drug Discovery and Target Identification against Schistosomiasis: A
Reality Check on Progress and Future Prospects
Authors: Cheuka Peter Mubanga 
Published: September 2021

:
Schistosomiasis ranks among the most important infectious diseases, with over 200
million people currently being infected and > 280,000 deaths reported annually. Chemotherapeutic
treatment has relied on one drug, praziquantel, for four decades, while other drugs, such as oxamniquine
and metrifonate, are no longer preferred for clinical use due to their narrow spectrum
of activity - these are only active against S. mansoni and S. haematobium, respectively. Despite
being cheap, safe, and effective against all schistosome species, praziquantel is ineffective against
immature worms, which may lead to reinfections and treatment failure in endemic areas; a situation
that necessitates repeated administration besides other limitations. Therefore, novel drugs are
urgently needed to overcome this situation. In this paper, an up to date review of drug targets
identified and validated against schistosomiasis while also encompassing promising clinical and
preclinical candidate drugs is presented. While there are considerable efforts aimed at identifying
and validating drug targets, the pipeline for new antischistosomals is dry. Moreover, the majority
of compounds evaluated preclinically are not really advanced because most of them were evaluated
in very small preclinical species such as mice alone. Overall, it appears that although a lot of
research is going on at discovery phases, unfortunately, it does not translate to advanced preclinical
and clinical evaluation.
Aktivitas olahraga bulu tangkis dan respon perubahan asam urat darah usia produktif
Authors: Kinasih Angkit , Djara Ronaldo Lomi , Karwur Ferry Fredy 
Published: September 2021

Penelitian ini bertujuan untuk mengetahui ada tidaknya respon perubahan pada kadar asam urat akibat aktivitas olahraga bulu tangkis. Desain penelitian ini adalah quasi eksperimen. Sampel yang digunakan sebanyak delapan responden dengan kriteria tertentu. Perlakukan aktivitas fisik dilakukan dua kali pada hari yang berbeda dengan 4 kali pengukuran kadar asam urat. Metode penelitian yang digunakan adalah repeated measure analysis. Ketika subyek diukur berulang kali dengan jumlah yang sedikit per percobaan maka repeated measures analysis dapat digunakan. Hasil penelitian menunjukkan bahwa perlakukan olahraga bulu tangkis memberikan respon perubahan yang signifikan terhadap perubahan kadar asam urat dengan nilai probabilitas sebesar 0,038. Hasil ini diperoleh dengan menggunakan uji Greenhouse-Geisser dimana asumsi normalitas dan homogenitas telah terpenuhi. Pada hasil uji marginal menggunakan pairwise comparisons, terdapat perbedaan yang signifikan pada rata-rata kadar asam urat 15 menit setelah olahraga dan jam 09.00 hari berikutnya, dimana terjadi penurunan sebesar 1,169 mg/dl. Olahraga bulu tangkis dapat menurunkan kadar asam urat yang ditandai dengan adanya penurunan sebesar 0,15 mg/dl pada jam 09.00 hari berikutnya dibandingkan dengan sebelum olahraga. Secara marginal, penurunan ini tidak signifikan secara statistik, namun olahraga bulu tangkis yang rutin dapat menjadi salah satu pilihan aktifitas fisik bagi yang ingin menurunkan kadar asam urat.The sports activity of badminton and responses to changes in blood uric acid at productive ageAbstractThis study aims to determine whether there was a response to changes in uric acid levels due to the physical activity of badminton. The design of this study is a quasi-experimental. The sample used in this study was eight respondents with certain criteria. Treat physical activity twice on different days with 4 measurements of uric acid levels. The method of this study is repeated measure analysis. When subjects are measured repeatedly, requiring fewer subjects per experiment, then repeated measures analysis can be used. The results showed that the treatment of badminton had a significant effect on changes in uric acid levels with a probability value of 0,038. These results were obtained by using the Greenhouse-Geisser test where the assumptions of normality and homogeneity were satisfied. From the marginal test results using pairwise comparisons, there was a significant difference in the average uric acid levels at 15 minutes after exercise and 9 hours the following day, where there was a decrease of 1.169 mg/dl. Badminton can reduce uric acid levels, which is indicated by a decrease of 0.15 mg/dl at 09.00 the next day compared to before exercise. Marginally, this decrease is not statistically significant, but regular badminton can be an option for physical activity for those who want to reduce uric acid levels.
Social Semiotics of Gangstalking Evidence Videos on YouTube: Multimodal Discourse Analysis of a Novel Persecutory Belief System
Authors: Lustig Andrew , Brookes Gavin , Hunt Daniel 
Published: September 2021

BackgroundGangstalking refers to a novel persecutory belief system wherein sufferers believe that they are being followed, watched, and harassed by a vast network of people in their community who have been recruited as complicit perpetrators. They are frequently diagnosed as mentally ill, although they reject this formulation. Those affected by this belief system self-identify as targeted individuals (TIs). They seek to prove the veracity of their persecution and dispute the notion that they are mentally ill by posting videos online that purport to provide evidence of their claims.ObjectiveThe objective of the study was to characterize the multimodal social semiotic practices used in gangstalking evidence videos.MethodsWe assembled a group of 50 evidence videos posted on YouTube by self-identified TIs and performed a multimodal social semiotic discourse analysis using a grounded theory approach to data analysis.ResultsTIs accomplished several social and interpersonal tasks in the videos. They constructed their own identity as subjects of persecution and refuted the notion that they suffered from mental illness. They also cultivated positive ambient affiliation with viewers of the videos but manifested hostility toward people who appeared in the videos. They made extensive use of multimodal deixis to generate salience and construe the gangstalking belief system. The act of filming itself was a source of conflict and served as a self-fulfilling prophecy; filming was undertaken to neutrally record hostility directed toward video bloggers (vloggers). However, the act of filming precipitated the very behaviors that they set out to document. Finally, the act of filming was also regarded as an act of resistance and empowerment by vloggers.ConclusionsThese data provide insight into a novel persecutory belief system. Interpersonal concerns are important for people affected, and they construe others as either sympathetic or hostile. They create positive ambient affiliation with viewers. We found that vloggers use multimodal deixis to illustrate the salience of the belief system. The videos highlighted the Derridean concept of différance, wherein the meaning of polysemous signifiers is deferred without definitive resolution. This may be important in communicating with people and patients with persecutory belief systems. Clinicians may consider stepping away from the traditional true/false dichotomy endorsed by psychiatric classification systems and focus on the ambiguity in semiotic systems generally and in persecutory belief systems specifically.
Use of an Online Ultrasound Simulator to Teach Basic Psychomotor Skills to Medical Students During the Initial COVID-19 Lockdown: Quality Control Study
Authors: Meuwly Jean-Yves , Mandralis Katerina , Tenisch Estelle , Gullo Giuseppe , Frossard Pierre , Morend Laura 
Published: September 2021

Background
Teaching medical ultrasound has increased in popularity in medical schools with hands-on workshops as an essential part of teaching. However, the lockdown due to COVID-19 kept medical schools from conducting these workshops.

Objective
The aim of this paper is to describe an alternative method used by our medical school to allow our students to acquire the essential psychomotor skills to produce ultrasound images.

Methods
Our students took online ultrasound courses. Consequently, they had to practice ultrasound exercises on a virtual simulator, using the mouse of their computer to control a simulated transducer. Our team measured the precision reached at the completion of simulation exercises. Before and after completion of the courses and simulator’s exercises, students had to complete a questionnaire dedicated to psychomotor skills. A general evaluation questionnaire was also submitted.

Results
A total of 193 students returned the precourse questionnaire. A total of 184 performed all the simulator exercises and 181 answered the postcourse questionnaire. Of the 180 general evaluation questionnaires that were sent out, 136 (76%) were returned. The average precourse score was 4.23 (SD 2.14). After exercising, the average postcourse score was 6.36 (SD 1.82), with a significant improvement (P<.001). The postcourse score was related to the accuracy with which the simulator exercises were performed (Spearman rho 0.2664; P<.001). Nearly two-thirds (n=84, 62.6%) of the students said they enjoyed working on the simulator. A total of 79 (58.0%) students felt that they had achieved the course’s objective of reproducing ultrasound images. Inadequate connection speed had been a problem for 40.2% (n=54) of students.

Conclusions
The integration of an online simulator for the practical learning of ultrasound in remote learning situations has allowed for substantial acquisitions in the psychomotor field of ultrasound diagnosis. Despite the absence of workshops, the students were able to learn and practice how to handle an ultrasound probe to reproduce standard images. This study enhances the value of online programs in medical education, even for practical skills.