bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended endoscopic transorbital approach with superior-lateral orbital rim osteotomy: cadaveric feasibility study and clinical implications (SevEN-007)
Authors: Lim *Jaejoon , Sung Kyoung Su , Kim Woohyun , Yoo Jihwan , Jung In-Ho , Choi Seonah , Lim Seung Hoon , Roh Tae Hoon , Hong Chang-Ki , Moon Ju Hyung 
Published: December 2021

OBJECTIVE
The endoscopic transorbital approach (ETOA) has been developed, permitting a new surgical corridor. Due to the vertical limitation of the ETOA, some lesions of the anterior cranial fossa are difficult to access. The ETOA with superior-lateral orbital rim (SLOR) osteotomy can achieve surgical freedom of vertical as well as horizontal movement. The purpose of this study was to confirm the feasibility of the ETOA with SLOR osteotomy.

METHODS
Anatomical dissections were performed in 5 cadaveric heads with a neuroendoscope and neuronavigation system. ETOA with SLOR osteotomy was performed on one side of the head, and ETOA with lateral orbital rim (LOR) osteotomy was performed on the other side. After analysis of the results of the cadaveric study, the ETOA with SLOR osteotomy was applied in 6 clinical cases.

RESULTS
The horizontal and vertical movement range through ETOA with SLOR osteotomy (43.8° ± 7.49° and 36.1° ± 3.32°, respectively) was improved over ETOA with LOR osteotomy (31.8° ± 5.49° and 23.3° ± 1.34°, respectively) (p < 0.01). Surgical freedom through ETOA with SLOR osteotomy (6025.1 ± 220.1 mm3) was increased relative to ETOA with LOR osteotomy (4191.3 ± 57.2 mm3) (p < 0.01); these values are expressed as the mean ± SD. Access levels of ETOA with SLOR osteotomy were comfortable, including anterior skull base lesion and superior orbital area. The view range of the endoscope for anterior skull base lesions was increased through ETOA with SLOR osteotomy. After SLOR osteotomy, the space for moving surgical instruments and the endoscope was widened. Anterior clinoidectomy could be achieved successfully using ETOA with SLOR osteotomy.
The authors performed ETOA with SLOR osteotomy in 6 cases of brain tumor. In all 6 cases, complete removal of the tumor was successfully accomplished. In the 3 cases of anterior clinoidal meningioma, anterior clinoidectomy was performed easily and safely, and manipulation of the extended dural margin and origin dura mater was possible. There was no complication related to this approach.

CONCLUSIONS
The authors evaluated the clinical feasibility of ETOA with SLOR osteotomy based on a cadaveric study. ETOA with SLOR osteotomy could be applied to more diverse disease groups that do not permit conventional ETOA or to cases in which surgical application is challenging. ETOA with SLOR osteotomy might serve as an opportunity to broaden the indication for the ETOA.
Associations between gait kinematics, gross motor function and physical activity among young people with cerebral palsy: A cross sectional study
Authors: Ryan Jennifer M. , Lavelle Grace , Noorkoiv Marika , Kiernan Damien , Theis Nicola , Little Úna , Shortland Adam , Malone Ailish 
Published: December 2021

INTRODUCTION: The aim of this study was to investigate the association between gait parameters, gross motor function and physical activity (PA) in young people with cerebral palsy (CP). METHODS: Thirty-eight adolescents aged between 10–19 years with spastic CP in GMFCS levels I-III (mean [standard deviation] age 13.7 [2.4] yr; 53%female) were included in this cross-sectional study. Hip, knee and ankle joint excursion and stance time was assessed using 3D gait analysis. Self-selected walking speed was assessed during a timed 10 m overground walk and treadmill walking. Gross motor function was assessed using dimensions D and E of the Gross Motor Function Measure (GMFM-66). Moderate-to-vigorous PA, light PA and step-count were assessed using an accelerometer. Linear regression was used to examine associations. RESULTS: After adjusting for age, sex and GMFCS level, percentage stance time was associated with dimension E of the GMFM-66 (β= –0.29, 95%CI –0.54 to –0.05). There was no evidence that any other gait parameters were associated with GMFM-66 dimensions D or E. There was also no evidence that gait parameters or GMFM-66 dimensions D or E were associated with step-count or time in PA after adjusting for age, sex and GMFCS level. DISCUSSION: The findings provide an insight into the complexity of the relationship between gait quality or ability at the impairment level, function as measured in a controlled environment, and the performance of habitual PA, which is essential for health among children with CP.
MULTIPLE REGRESSION MODELING THE CHEMICAL COMPOSITION EFFECTS ON THE TENSILE STRENGTH OF Ni-BASED SUPERALLOYS
Authors: Nengjun Ben , Tkachenko Igor , Miroshnichenko Victoria , Gavrilova Viktoria , Sapronov Oleksandr 
Published: December 2021

Based on the previously obtained results of the Data Mining - based Classification and Regression Trees (C&RT) technique application to industrial Ni-based superalloys, multiple regression models were developed to describe quantitatively the chemical composition effects on the alloys tensile strength. The regression models obtained were verified for adequacy in three ways, contrary to the conventional approach requiring only several inadequacy variance values calculations. Namely, the following verification methods were applied: traditional R2 coefficient calculations; comparisons of computer and experimental frequency distributions of the quality indexes; Monte-Carlo simulated and experimental data based scatter plots comparing. It was emphasized that, according to the general statistic principle, close coincidence of the Monte-Carlo simulated and real frequency distributions of any measured characteristic values means full formal (statistical) identity of the real and simulated objects. Hence, in addition, coincidence of the corresponding scatter plots statistical parameters should be considered as a sign of the physical identity of real and modeled regression dependencies. All the applied verification methods show the excellent results that leads to conclusion about high workability of the obtained models in practical and theoretical applications. An additional general advantage of the models was noted: their physically interpretable structure, that provides the opportunity to determine and analyze the effects of individual chemical elements and their interactions under real industrial conditions. Most of the obtained results and the formulated conclusions, especially related to the chemical elements individual effects are in good accordance with the known experimental and theoretic data for polycrystalline Ni-based superalloys. Meantime, some unexpected features, particularly, for the interactions of Nb, Ti, Cu with each other and grain boundaries were revealed, showing necessity of further in dept investigations.
Structural Analysis and 3D Timber Spatial Structure Modeling
Authors: Budko Тatiana , Lavrinenko2 Lyudmila 
Published: December 2021

The analysis of the structural form of the multi-volume dome structure using load-bearing wooden arches is performed. The complexity of the volumes and their connecting lines, as well as the requirement to conduct a non-linear analysis of long-span wooden elements at the request of Eurocode 5 make the information model necessary. It is noted that the design using this technology is developing in the direction of taking into account all stages of the structure life cycle. Information modeling of wooden structures in the world is the most prepared for the use of BIM-technologies. This is due to the sophisticated digital technologies for the production of modern wooden structures elements. An information model was formed for designing according to the regulations of Ukraine. The Information Model was created in the SAPFIR software package for further possibility of importing the model into the LIRA-CAD software package. The necessary auxiliary steps were used to build the model. The loads on the curved surface were calculated in the PC Espri. For further development of the nodes, 3D-modeling was used with the transfer of the information model into the PC Tekla Structures as a specialized environment for the constructive section of the project.
The presented analysis of the complex dome structure using wooden arches summarizes the approaches to the development of unique forms of structures using wood. The use of information models has significantly increased the complexity of architectural design and structural model taking into account the nonlinear effects of wood. The possibility of integrating these tools for further implementation in BIM-technology is shown.
Modeling of joint work of steel beam constructions with reinforced concrete ribbed floor slabs
Authors: Dmytrenko Yevhen 
Published: December 2021

Traditional methods of calculation of beam constructions of floors and coverings of industrial buildings assume their consideration when calculating separately from the frame structures, in particular, reinforced concrete slabs, without taking into account their joint work, which leads to a significant margin of safety. Today in Ukraine there is a significant number of industrial buildings and structures that need strengthening and reconstruction.
In this regard, of particular importance are studies of the actual load-bearing capacity of the frames of single-storey and multi-storey industrial buildings, and both in the reconstruction and in new construction, the results of which will significantly reduce costs and more rationally design structures.
At the same time, one of the most relevant areas is the study of the joint work of metal load-bearing structures with prefabricated reinforced concrete structures of rigid disks of coatings and floors in their calculation.

Moreover, in the national building codes, as well as in the educational and methodological literature, the calculation methods of taking into account the joint work of such constructions are not fully covered.
The purpose of this work is to estimate the reduction of mass of the metal beam structure in its calculation in bending, taking into account the joint work with the rigid disk of the floor consist of precast concrete.
As part of the study, the calculation of the floor beam according to the traditional calculation scheme - without taking into account the joint work with the floor slab, the calculation of its cross-section taking into account the joint work with floor slabs and experimental numerical study of the floor by the finite element method. Modeling of the floor fragment was performed in the software packages "SCAD Office" and "LIRA CAD 2019".
Numerical research is aimed at verifying the feasibility of using the calculation methodology of DBN B.2.6-98-2009 to determine the effective width of the shelf when calculating the T-sections for prefabricated reinforced concrete slabs, which are included in the joint work with the floor beams.
A comparative analysis of the obtained cross-section of the beam with the beam which was previously calculated by the traditional method of calculation in stresses in the most dangerous cross section and the total mass of the beams.
According to the results of the analysis, the correctness of the application of the above normative method for determining the effective width of the shelf of T-bending reinforced concrete elements was confirmed.
EDUKASI MASYARAKAT MELALUI AKTIVITAS RELAWAN NON MEDIS DALAM MEMUTUS RANTAI PENYEBARAN COVID-19 DI LINGKUNGAN CAKRANEGARA UTARA
Authors: Diarti Maruni Wiwin , Jiwintarum Yunan , Dramawan Awan 
Published: December 2021

Coronavirus Disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). WHO sudah menetapkan Covid-19 sebagai pandemi. Virus Covid-19 umumnya ditransmisikan melalui kontak fisik erat dan percikan (droplet) dari saluran pernapasan, sedangkan transmisi melalui udara (airborne) dapat terjadi saat melakukan prosedur medis yang menghasilkan aerosol. Cakranegara Utara merupakan salah satu kelurahan di Kota Mataram yang sampai dengan bulan Agustus 2020 masih ditetapkan sebagai Zona merah. Peran masyarakat diakui cukup penting untuk menekan kasus Covid-19 yang terus bertambah. Relawan non medis merupakan kelompok mahasiswa yang peduli terhadap Covid-19. Pendekatan edukasi masyarakat melalui aktivitas relawan non medis dalam kegiatan pengabdian masyarakat ini diharapkan dapat mencegah penyebaran Covid 19 di lingkungan Cakranegara Utara. Metode yang digunakan dalam Edukasi Masyarakat melalui aktivitas relawan non medis dalam memutus rantai penularan Covid-19 melalui ceramah, metode diskusi dan metode demonstrasi. Untuk mengetahui keberhasilan edukasi pada masyarakat melalui aktivitas relawan non medis ini dilakukan pretest dan posttest pada masyarakat. Hasil menunjukkan terjadi peningkatan pengetahuan masyarakat mengenai cara cuci tangan yang benar (WHO), Covid-19 dan pencegahannya dan Edukasi masyarakat melalui aktivitas relawan non medis dapat meningkatkan pengetahuan masyarakat tentang tentang cara mencuci tangan dengan benar (WHO), Covid-19 dan cara pencegahannya, social distancing dan manfaat pengunaan masker untuk memutus rantai penularan Covid-19.
EDUKASI PADA IBU BALITA TENTANG PEMANFAATAN DAUN KELOR (MORINGA OLEIFERA) SEBAGAI KUDAPAN UNTUK PENCEGAHAN STUNTING
Authors: Wahyuningsih Retno , Darni Joyeti 
Published: December 2021

Stunting sering dijumpai pada anak usia 12-36 bulan, anak yang mengalami stunting pada masa ini cenderung akan sulit mencapai tinggi badan yang optimal pada periode selanjutnya. Untuk mencegah terjadinya stunting pada anak, ibu perlu mengonsumsi asupan gizi yang layak, dan memiliki pengetahuan gizi yang baik. Upaya perbaikan stunting dapat dilakukan dengan peningkatan pengetahuan sehingga dapat memperbaiki perilaku pemberian makan pada anak. Tujuan kegiatan adalah untuk meningkatkan pengetahuan ibu balita mengenai pemanfaatan daun kelor (Moringa Oleifera) sebagai kudapan untuk mencegah masalah stunting. Metode melalui penyuluhan (pemaparan melalui ceramah secara langsung) dan pengisian kuesioner pre-post test untuk mengetahui dan menilai tingkat keberhasilan penyuluhan yang dilakukan. Didapatkan hasil rata-rata skor pengetahuan sebelum penyuluhan termasuk dalam kategori baik (nilai ≥80) sebanyak 13,5%, dan pengetahuan kurang sebanyak 86,5%. Setelah penyuluhan didapatkan skor pengetahuan baik sebanyak 54,1% dan kurang sebanyak 45,9%. Kesimpulannya terdapat peningkatan pengetahuan sesudah diberikan penyuluhan tentang stunting dan kudapan dari daun kelor.
Fatal disseminated paradoxical embolism in inferior sinus venosus atrial septal defect
Authors: Ismail Zul Khairul Azwadi , Sayuti Khairil Amir , Abdullah Mohd Shafie 
Published: December 2021

Inferior sinus venosus arterial septal defect (ASD) is a rare congenital cardiac anomaly. As with other types of ASDs and patent foramen ovale (PFO), this defect results in arteri-venous shunting with the risk of developing paradoxical embolism (PDE) to the systemic circulation from venous emboli. We report a case of a 67-year-old lady presented to emergency department (ED) with massive pulmonary embolism (PE) and recurrent acute limb ischaemia. On CT pulmonary angiography (CTPA), an incidental finding of inferior sinus venosus ASD was discovered that has caused the PDE. Thrombolysis was administered followed by open mechanical thrombectomy. The patient developed massive lower gastrointestinal bleed post thrombolysis then passed away despite embolization. This case report describes the catastrophic effect of PDE to cause disseminated multisystem thromboembolism. It also emphasizes the importance of early detection of a possible right-to-left shunt in patients presented with recurrent acute limb ischaemia. Transthoracic echocardiography has reduced sensitivity for inferior sinus venosus ASD requiring further assessment with transoesophageal echocardiography in selected cases.
Matricellular Protein Periostin Promotes Pericyte Migration in Fibrotic Airways
Authors: Bignold Rebecca E. , Johnson Jill R. 
Published: December 2021

Introduction: Periostin is a matricellular protein that is currently used as a biomarker for asthma. However, its contribution to tissue remodeling in allergic asthma is currently unknown. We have previously demonstrated that tissue-resident mesenchymal stem cells known as pericytes are a key cell type involved in airway remodeling. This is thought to be caused the uncoupling of pericytes from the microvasculature supporting the large airways, facilitated by inflammatory growth factors and cytokines. It is hypothesized that periostin may be produced by profibrotic pericytes and contribute to the remodeling observed in allergic asthma.Methods: Lung sections from mice with allergic airway disease driven by exposure to house dust mite (HDM) were stained using an anti-periostin antibody to explore its involvement in fibrotic lung disease. Human pericytes were cultured in vitro and stained for periostin to assess periostin expression. Migration assays were performed using human pericytes that were pretreated with TGF-β or periostin. ELISAs were also carried out to assess periostin expression levels in bronchoalveolar lavage fluid as well as the induction of periostin production by IL-13.Results: Immunostaining indicated that pericytes robustly express periostin, with increased expression following treatment with TGF-β. Migration assays demonstrated that pericytes treated with periostin were more migratory. Periostin production was also increased in HDM exposed mice as well as in cultured pericytes treated with IL-13.Conclusion: Periostin is produced by pericytes in response to TGF-β or IL-13, and periostin plays a key role in inducing pericyte migration. The increase in periostin expression in TGF-β or IL-13 treated pericytes suggests that IL-13 may trigger periostin production in pericytes whilst TGF-β modulates periostin expression to promote pericyte migration in the context of tissue fibrosis.
Influence of Menisci on Tibiofemoral Contact Mechanics in Human Knees: A Systematic Review
Authors: Sukopp Matthias , Schall Florian , Hacker Steffen P. , Ignatius Anita , Dürselen Lutz , Seitz Andreas M. 
Published: December 2021

Purpose: Menisci transfer axial loads, while increasing the load-bearing tibiofemoral contact area and decreasing tibiofemoral contact pressure (CP). Numerous clinical and experimental studies agree that an increased CP is one predominant indicator for post-traumatic osteoarthritis (PTOA) of the knee joint. However, due to the immense variability in experimental test setups and wide range of treatment possibilities in meniscus surgery, it is difficult to objectively assess their impact on the CP determination, which is clearly crucial for knee joint health. Therefore, the aim of this systematic review is to investigate the influence of different meniscal injuries and their associated surgical treatments on the CP. Secondly, the influence of different test setups on CP measurements is assessed. On the basis of these results, we established the basis for recommendations for future investigations with the aim to determine CPs under different meniscal states.Methods: This review was conducted in accordance with the PRISMA guidelines. Studies were identified through a systematic literature search in Cochrane, PubMed and Web of Science databases. Literature was searched through pre-defined keywords and medical subject headings.Results: This review indicates a significant increase of up to 235% in peak CP when comparing healthy joints and intact menisci with impaired knee joints, injured or resected menisci. In addition, different test setups were indicated to have major influences on CP: The variety of test setups ranged from standard material testing machines, including customized setups via horizontal and vertical knee joint simulators, through to robotic systems. Differences in applied axial knee joint loads ranged from 0 N up to 2,700 N and resulted unsurprisingly in significantly different peak CPs of between 0.1 and 12.06 MPa.Conclusion: It was shown that untreated traumatic meniscal tears result in an increased CP. Surgical repair intervention were able to restore the CP comparable to the healthy, native condition. Test setup differences and particularly axial joint loading variability also led to major CP differences. In conclusion, when focusing on CP measurements in the knee joint, transparent and traceable in vitro testing conditions are essential to allow researchers to make a direct comparison between future biomechanical investigations.
Overground Walking in a Fully Immersive Virtual Reality: A Comprehensive Study on the Effects on Full-Body Walking Biomechanics
Authors: Horsak Brian , Simonlehner Mark , Schöffer Lucas , Dumphart Bernhard , Jalaeefar Arian , Husinsky Matthias 
Published: December 2021

Virtual reality (VR) is an emerging technology offering tremendous opportunities to aid gait rehabilitation. To this date, real walking with users immersed in virtual environments with head-mounted displays (HMDs) is either possible with treadmills or room-scale (overground) VR setups. Especially for the latter, there is a growing interest in applications for interactive gait training as they could allow for more self-paced and natural walking. This study investigated if walking in an overground VR environment has relevant effects on 3D gait biomechanics. A convenience sample of 21 healthy individuals underwent standard 3D gait analysis during four randomly assigned walking conditions: the real laboratory (RLab), a virtual laboratory resembling the real world (VRLab), a small version of the VRlab (VRLab−), and a version which is twice as long as the VRlab (VRLab+). To immerse the participants in the virtual environment we used a VR-HMD, which was operated wireless and calibrated in a way that the virtual labs would match the real-world. Walking speed and a single measure of gait kinematic variability (GaitSD) served as primary outcomes next to standard spatio-temporal parameters, their coefficients of variant (CV%), kinematics, and kinetics. Briefly described, participants demonstrated a slower walking pattern (−0.09 ± 0.06 m/s) and small accompanying kinematic and kinetic changes. Participants also showed a markedly increased gait variability in lower extremity gait kinematics and spatio-temporal parameters. No differences were found between walking in VRLab+ vs. VRLab−. Most of the kinematic and kinetic differences were too small to be regarded as relevant, but increased kinematic variability (+57%) along with increased percent double support time (+4%), and increased step width variability (+38%) indicate gait adaptions toward a more conservative or cautious gait due to instability induced by the VR environment. We suggest considering these effects in the design of VR-based overground training devices. Our study lays the foundation for upcoming developments in the field of VR-assisted gait rehabilitation as it describes how VR in overground walking scenarios impacts our gait pattern. This information is of high relevance when one wants to develop purposeful rehabilitation tools.