bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgery decision conflict and its related factors among newly diagnosed early breast cancer patients in China: A cross‐sectional study
Authors: Tang Han , Wang Shang , Dong Shiqi , Du Ruofei , Yang Xiao , Cui Panpan , Liu Wei , Kou Jie , Chen Changying 
Published: February 2021

AbstractAimThe aim of this study was to explore surgery decision conflict and its related factors among newly diagnosed early breast cancer patients in China.DesignA cross‐sectional survey study was conducted.MethodsA total of 262 patients confronted with surgery decision‐making were enrolled. The related factors were assessed with a demographic questionnaire, the Chinese version of the Decision Conflict Scale (DCS‐C‐16) and the Patient Participation Competence Scale (PPCS).ResultsPatients had a high level of decision conflict that was negatively correlated with the PPCS score. Age, marital status, living environment, education level, family income, cancer stage and the PPCS score were independent factors influencing decision conflict. Marital status, education level, cancer stage and participation competence were significant predictors of decision conflict. Patients who had higher participation competence were married, were well educated and had a lower cancer stage were likely to experience lower decision conflict.
FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†
Authors: Romanello Vanina 
Published: February 2021

AbstractThe metabolic regulator fibroblast growth factor 21 (FGF21) has been reported as a cardioprotective factor regulating cardiac remodeling in several cardiac diseases. In a recent issue of The Journal of Pathology, Ferrer‐Curriu, Guitart‐Mampel et al investigated FGF21 in alcoholic cardiomyopathy (ACM). They showed that FGF21 deficiency aggravates alcohol‐induced cardiac damage and dysfunction by exacerbating mitochondrial alterations, oxidative stress, and lipid metabolic dysregulation, suggesting FGF21 as a promising therapeutic agent in ACM. Paradoxically, FGF21 cardiac and circulating levels correlate with cardiac damage and oxidative stress in patients with ACM, pointing to FGF21 as a potential biomarker of alcohol‐induced cardiac damage. Further studies are needed to address when FGF21 can be used as a diagnostic biomarker and when it can be used as a therapeutic agent to treat ACM. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Layered self‐resistance electric heating to cure thick carbon fiber reinforced epoxy laminates
Authors: Zhang Bo , Li Yingguang , Liu Shuting , Shen Yingxiang , Hao Xiaozhong 
Published: February 2021

AbstractCuring of thick carbon fiber reinforced thermosetting composite laminates has been a major challenge due to the undesired through‐thickness temperature gradient. In this paper, a novel layered self‐resistance electric heating (L‐SRE) method to cure thick laminates was proposed. The thick laminate was divided into multiple independent sub‐layers, and the temperature of each sub‐layer was controlled individually. The experiment's results revealed that L‐SRE was able to achieve highly homogeneous temperature distribution filed through‐thickness both in rapid heating and exothermic reaction stages. The maximum temperature difference of dwell stage for L‐SRE process was less than 4.0°C, and the L‐SRE process that had an optimized thickness of each sub‐layer achieved the minimum mean temperature deviation of 2.1°C, which was 88.46% lower than that of the oven process. By using the optimized L‐SRE method, the maximum value of crosslink thermal overshoot was 12.2°C (32.5°C for oven curing). Different layered temperature control strategies were explored, and the lowest energy consumption of 309.7 Wh (19.82% of oven process) was achieved by using the single‐power pulsed heating. The method proposed in this paper provided a new solution for high‐quality and energy‐efficient curing of thick laminates.
Registration of ‘Charro’ pinto bean
Authors: Kelly James D. , Awale Halima E. , Wiersma Andrew T. , Wright Evan M. 
Published: February 2021

Abstract‘Charro’ pinto bean (Phaseolus vulgaris L.) (Reg. no. CV‐341, PI 695318), developed by Michigan State University AgBioResearch, was released in 2020 as a high‐yielding, upright, full‐season cultivar with excellent canning quality. Charro was developed using the pedigree breeding method to the F4 generation followed by pure line selection for disease, agronomic, and quality traits. In 4 yr of field trials, Charro yielded 3,230 kg ha−1 at 17 locations in mid‐Michigan, flowered in 46 d, and matured in 97 d on average. Plants averaged 52 cm in height, with a lodging resistance score of 1.6 and seed weight of 41.2 g per 100 seed. Charro combines high yield potential and erect architecture with full‐season maturity in a pinto seed type. Charro has resistance to lodging and high pod placement within the plant structure, making it suitable for direct harvest under narrow‐row production systems. The upright architecture also contributes to avoidance of white mold, a disease that is intensified under narrow‐row production systems. Charro exhibits the top necrosis reaction to strain NL 3 of Bean common mosaic necrosis virus. Charro produces seed that meets industry standards for export and packaging, and canning quality was rated excellent for the pinto bean seed class.
Nanoscale chemical analysis of beam‐sensitive polymeric materials by cryogenic electron microscopy
Authors: Leijten Zino J. W. A. , Wirix Maarten J. M. , Lazar Sorin , Verhoeven Wouter , Luiten O. Jom , de With Gijsbertus , Friedrich Heiner 
Published: February 2021

AbstractNanoscale chemical analysis of functional polymer systems by electron microscopy, to gain access into degradation processes during the materials life cycle, is still a formidable challenge due to their beam sensitivity. Here a systematic study on the different stages of degradation in a P3HT‐PCBM organic photovoltaic (OPV) model system is presented. To this end pristine samples, samples with (reversibly) physisorbed oxygen and water and samples with (irreversibly) chemisorbed oxygen and water are imaged utilizing the full capabilities of cryogenic STEM‐EELS. It is found that oxygen and water are largely physisorbed in this system leading to significant effects on the band structure, especially for PCBM. Quantification proves that degradation concomitantly decreases the amount of CC bonds and increases the amount of COC bonds in the sample. Finally, it is shown that with a pulsed electron beam utilizing a microwave cavity, beam damage can be significantly reduced which likely extends the possibilities for such studies in future.
Respiratory synchrony comparison between preterm and full‐term neonates using inertial sensors
Authors: de Paula Silveira Letícia , Magalhães Fabrício Anicio , de Oliveira Holanda Norrara Scarlytt , Bezerra Mickaelly Yanaê Gomes , Bomtempo Raffi Antunes Braga , Pereira Silvana Alves , Ribeiro Simone Nascimento Santos 
Published: February 2021

AbstractIntroductionDue to inefficient respiratory control, newborns become prone to asynchronous thoracoabdominal (TA) movements. The present study quantitatively estimated the synchrony of TA in preterm and full‐term newborns through an inertial and magnetic measurement units (IMMUs) system.MethodsThis cross‐sectional study was conducted with 20 newborns divided into Preterm Group (PTG, n = 10) and Full‐Term Group (FTG, n = 10). Each neonate had IMMUs placed on the sternum and near the umbilicus, thus the TA motion was estimated through the resultant inclination angles calculated using a sensor fusion filter. The respiratory incursions were also manually counted and video‐recorded for two minutes, then used to validate a Matlab custom‐written routine for their automatic identification. The respiratory cycles were used to calculate the phase change angle (φ) between the thoracic and abdominal compartments. Association between the manual and automatic methods were verified by Pearson's correlation and root mean squared errors (RMSE), and the comparison between the groups was performed through the Student's t test with α = .05.ResultsThe values of respiratory incursions measured by both methods showed a high association and low measurement error (r = .96, RMSE = 9.8, p < .001). The FTG presented a higher occurrence of TA synchrony (p = .049) while the PTG group presented a higher occurrence of TA asynchrony (p = .036). No difference was found between the groups regarding the paradoxical classification (p = .071).ConclusionThe proposed method was valid to quantitatively assess the TA synchrony of hospitalized neonates. Preterm infants had a higher occurrence of the asynchronous respiratory pattern in comparison to full‐term infants.
Sulfur Promotion in Au/C Catalyzed Acetylene Hydrochlorination
Authors: Dawson Simon R. , Pattisson Samuel , Malta Grazia , Dummer Nicholas F. , Smith Louise R. , Lazaridou Anna , Allen Christopher S. , Davies Thomas E. , Freakley Simon J. , Kondrat Simon A. , Kiely Christopher J. , Johnston Peter , Hutchings Graham J. 
Published: February 2021

AbstractThe formation of highly active and stable acetylene hydrochlorination catalysts is of great industrial importance. The successful replacement of the highly toxic mercuric chloride catalyst with gold has led to a flurry of research in this area. One key aspect, which led to the commercialization of the gold catalyst is the use of thiosulphate as a stabilizing ligand. This study investigates the use of a range of sulfur containing compounds as promoters for production of highly active Au/C catalysts. Promotion is observed across a range of metal sulfates, non‐metal sulfates, and sulfuric acid treatments. This observed enhancement can be optimized by careful consideration of either pre‐ or post‐treatments, concentration of dopants used, and modification of washing steps. Pre‐treatment of the carbon support with sulfuric acid (0.76 m) resulted in the most active Au/C in this series with an acetylene conversion of ≈70% at 200 °C.
Transdisciplinary contributions and opportunities in soil physical hydrology
Authors: Wendroth Ole , Bradford Scott , Harter Thomas 
Published: February 2021

AbstractAs in many other soil science disciplines, in soil physics and hydrology, we have arrived at a point where substantial gains in knowledge depend to a large extent on reaching out to related disciplines. The purpose of this special section on “Transdisciplinary Contributions and Opportunities in Soil Physical Hydrology” is to honor Professor Emeritus Jan W. Hopmans, University of California Davis, CA, as one of the pioneers in transdisciplinary research. In this introduction, the 12 articles collected for this special section are summarized, and their relationship to Hopmans’ work during his productive career is emphasized. The contributions reflect the depth and width of soil physics and hydrology and are aimed to stimulate transdisciplinary science to meet the existing challenges in agriculture and the environment.
Non-Lorentzian avatars of (1,0) theories
Authors: Lambert N. , Orchard T. 
Published: February 2021

Abstract
We construct five-dimensional non-Lorentzian Lagrangian gauge field theories with an SU(1, 3) conformal symmetry and 12 (conformal) supersymmetries. Such theories are interesting in their own right but can arise from six-dimensional (1, 0) superconformal field theories on a conformally compactified Minkowski spacetime. In the limit that the conformal compactification is removed the Lagrangians we find give field theory formulations of DLCQ constructions of six-dimensional (1, 0) conformal field theories.
Das Hautarztverfahren nach Aufhebung des Unterlassungszwangs im Berufskrankheitenrecht
Authors: Elsner Peter 
Published: February 2021

ZusammenfassungDie Berufskrankheit (BK) Haut Nr. 5101 war bisher definiert als „schwere oder wiederholt rückfällige Hauterkrankungen, die zur Unterlassung aller Tätigkeiten gezwungen haben, die für die Entstehung, die Verschlimmerung oder das Wiederaufleben der Krankheit ursächlich waren oder sein können“. In einer weitreichenden Reform des Berufskrankheitenrechts, die zum 01.01.2021 in Kraft trat, hat der Gesetzgeber beschlossen, den „Unterlassungszwang“ als Voraussetzung für die Anerkennung einer Berufskrankheit abzuschaffen. Dieser Unterlassungszwang sollte mit dem 1972 eingeführten Hautarztverfahren und den dort etablierten Präventionsinstrumenten (dermatologische Behandlung, Sanierung des Arbeitsplatzes, Hautschutzmaßnahmen, gesundheitspädagogische Maßnahmen) verhindert werden, was in einem Großteil der Fälle auch gelang. Während die Abschaffung des Unterlassungszwangs die Anerkennung von schweren oder wiederholt rückfälligen Hauterkrankungen als Berufskrankheiten erleichtert, wird das Hautarztverfahren jedoch weiterhin Bedeutung behalten für die beruflichen Hauterkrankungen, insbesondere Handekzeme, die primär nicht die Kriterien der Schwere und/oder der wiederholten Rückfälligkeit erfüllen und die durch geeignete Behandlungs- und Präventionsmaßnahmen beherrscht werden können. Um bei einer BK-Anzeige wegen der Schwere oder wiederholten Rückfälligkeit einer Hauterkrankung Verzögerungen in der Sekundärprävention zu vermeiden, sollte gleichzeitig über einen Hautarztbericht zur BK-Anzeige der Unfallversicherungsträger die für zeitnahe Präventionsmaßnahmen und einen dermatologischen Behandlungsauftrag erforderlichen Informationen erhalten. Ein Anhaltspunkt für die Schwere könnte der Erfolg oder der Misserfolg des Hautarztverfahrens sein.
Tiefe Hirnstimulation bei neurologischen und psychiatrischen Erkrankungen
Authors: Klebe Stephan , Coenen Volker 
Published: February 2021

ZusammenfassungDie invasive Hirnstimulation (tiefe Hirnstimulation [THS], „deep brain stimulation“ [DBS]) ist mittlerweile ein etabliertes Therapieverfahren bei einer Reihe neurologischer Erkrankungen insbesondere Bewegungsstörungen. Die Anzahl der mit einer THS versorgten Patienten steigt stetig, die technische Entwicklung der THS-Systeme schreitet voran und neue Indikationen werden aktuell in Studien überprüft. Im folgenden Beitrag soll ein Überblick über die aktuellen Indikationen und ein Ausblick auf zukünftige Entwicklungen der THS bei Bewegungsstörungen und psychiatrischen Erkrankungen gegeben werden.
Cure rate in the elderly patients with diffuse large B cell lymphoma deteriorates after the age of 80—results from a single-center survey
Authors: Freudenberger Felix , Ohler Anke , Theobald Matthias , Hess Georg 
Published: February 2021

AbstractThe prognosis of elderly patients diagnosed with diffuse large B cell lymphoma (DLBCL) is considered to be clearly inferior to that of younger patients. Besides tumor biology and comorbidities, treatment selection due to an assumed reduced tolerability may contribute to this difference. With increasingly more patients diagnosed at advanced age, current treatment selections need to be reviewed carefully. Hence, we analyzed the results of patients above the age of 70 in whom a diagnosis of DLBCL was made. Whereas patients up to 80 were frequently selected for and were able to tolerate standard treatment (86% intended use, 74% completion), patients above the age of 80 years were not only treated more cautiously (67 and 60%, respectively) but did show inferior response to treatment with standard treatment (CR rate for intended R-CHOP use 64% vs. 43%). However, on an individual level, patients receiving and completing standard treatment obtained results that resemble the results of younger patients, irrespective if aged more than 80 and impose superior to prior reports in this age cohort. Median PFS for the entire group of patients was 3.44 years, with 4.83 years for patients below 80 and only 1.09 years for patients above the age of 80. The corresponding figures for OS were 7.38 years (estimated); after 2 years, OS was 81% in the younger cohort in contrast to 68% in patients > 80 years. However, for patients not planned to receive or not tolerating R-CHOP, results remain poor; tailored approaches for these patients are required.
Contrast agent dose reduction in computed tomography with deep learning using a conditional generative adversarial network
Authors: Haubold Johannes , Hosch René , Umutlu Lale , Wetter Axel , Haubold Patrizia , Radbruch Alexander , Forsting Michael , Nensa Felix , Koitka Sven 
Published: February 2021

Abstract
Objectives
To reduce the dose of intravenous iodine-based contrast media (ICM) in CT through virtual contrast-enhanced images using generative adversarial networks.

Methods
Dual-energy CTs in the arterial phase of 85 patients were randomly split into an 80/20 train/test collective. Four different generative adversarial networks (GANs) based on image pairs, which comprised one image with virtually reduced ICM and the original full ICM CT slice, were trained, testing two input formats (2D and 2.5D) and two reduced ICM dose levels (−50% and −80%). The amount of intravenous ICM was reduced by creating virtual non-contrast series using dual-energy and adding the corresponding percentage of the iodine map. The evaluation was based on different scores (L1 loss, SSIM, PSNR, FID), which evaluate the image quality and similarity. Additionally, a visual Turing test (VTT) with three radiologists was used to assess the similarity and pathological consistency.

Results
The −80% models reach an SSIM of > 98%, PSNR of > 48, L1 of between 7.5 and 8, and an FID of between 1.6 and 1.7. In comparison, the −50% models reach a SSIM of > 99%, PSNR of > 51, L1 of between 6.0 and 6.1, and an FID between 0.8 and 0.95. For the crucial question of pathological consistency, only the 50% ICM reduction networks achieved 100% consistency, which is required for clinical use.

Conclusions
The required amount of ICM for CT can be reduced by 50% while maintaining image quality and diagnostic accuracy using GANs. Further phantom studies and animal experiments are required to confirm these initial results.

Key Points
• The amount of contrast media required for CT can be reduced by 50% using generative adversarial networks.
• Not only the image quality but especially the pathological consistency must be evaluated to assess safety.
• A too pronounced contrast media reduction could influence the pathological consistency in our collective at 80%.
Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients
Authors: Bach Patrick , Schuster Rilana , Koopmann Anne , Vollstaedt-Klein Sabine , Spanagel Rainer , Kiefer Falk 
Published: February 2021

AbstractRecent studies on the pathophysiology of alcohol dependence suggest a link between peripheral calcium concentrations and alcohol craving. Here, we investigated the association between plasma calcium concentration, cue-induced brain activation, and alcohol craving. Plasma calcium concentrations were measured at the onset of inpatient detoxification in a sample of N = 115 alcohol-dependent patients. Alcohol cue-reactivity was assessed during early abstinence (mean 11.1 days) using a functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task. Multiple regression analyses and bivariate correlations between plasma calcium concentrations, clinical craving measures and neural alcohol cue-reactivity (CR) were tested. Results show a significant negative correlation between plasma calcium concentrations and compulsive alcohol craving. Higher calcium levels predicted higher alcohol cue-induced brain response in a cluster of frontal brain areas, including the dorsolateral prefrontal cortex (dlPFC), the anterior prefrontal cortex (alPFC), and the inferior (IFG) and middle frontal gyri (MFG). In addition, functional brain activation in those areas correlated negatively with craving for alcohol during fMRI. Higher peripheral calcium concentrations during withdrawal predicted increased alcohol cue-induced brain activation in frontal brain areas, which are associated with craving inhibition and cognitive control functions. This might indicate that higher plasma calcium concentrations at onset of detoxification could modulate craving inhibition during early abstinence.Trial registration number: DRKS00003388; date of registration: 14.12.2011.
Clinical condition of 120 patients alive at 3 years after poor-grade aneurysmal subarachnoid hemorrhage
Authors: Autio Anniina H. , Paavola Juho , Tervonen Joona , Lång Maarit , Huuskonen Terhi J. , Huttunen Jukka , Kärkkäinen Virve , von und zu Fraunberg Mikael , Lindgren Antti E. , Koivisto Timo , Jääskeläinen Juha E. , Kämäräinen Olli-Pekka 
Published: February 2021

Abstract
Background
To study the clinical condition of poor-grade aneurysmal subarachnoid hemorrhage (aSAH) patients alive at 3 years after neurointensive care.

Methods
Of the 769 consecutive aSAH patients from a defined population (2005–2015), 269 (35%) were in poor condition on admission: 145 (54%) with H&H 4 and 124 (46%) with H&H 5. Their clinical lifelines were re-constructed from the Kuopio Intracranial Aneurysm Database and Finnish nationwide registries. Of the 269 patients, 155 (58%) were alive at 14 days, 125 (46%) at 12 months, and 120 (45%) at 3 years.

Results
The 120 H&H 4–5 patients alive at 3 years form the final study population. On admission, 73% had H&H 4 but only 27% H&H 5, 59% intracerebral hematoma (ICH; median 22 cm3), and 26% intraventricular blood clot (IVH). The outcome was favorable (mRS 0–1) in 45% (54 patients: ICH 44%; IVH clot 31%; shunt 46%), moderate (mRS 2–3) in 30% (36 patients: ICH 64%; IVH clot 19%; shunt 42%), and unfavorable (mRS 4–5) in 25% (30 patients: ICH 80%; IVH clot 23%; shunt 50%). A total of 46% carried a ventriculoperitoneal shunt. ICH volume was a significant predictor of mRS at 3 years.

Conclusions
Of poor-grade aSAH patients, 45% were alive at 3 years, even 27% of those extending to pain (H&H 5). Of the survivors, 75% were at least in moderate condition, while only 2.6% ended in hospice care. Consequently, we propose non-selected admission to neurointensive care (1) for a possibility of moderate outcome, and (2), in case of brain death, possibly improved organ donation rates.
Past, present, future: tracking and simulating genetic differentiation over time in a closed metapopulation system
Authors: Kunz Florian , Kohnen Annette , Nopp-Mayr Ursula , Coppes Joy 
Published: February 2021

AbstractGenetic differentiation plays an essential role in the assessment of metapopulation systems of conservation concern. Migration rates affect the degree of genetic differentiation between subpopulations, with increasing genetic differentiation leading to increasing extinction risk. Analyses of genetic differentiation repeated over time together with projections into the future are therefore important to inform conservation. We investigated genetic differentiation in a closed metapopulation system of an obligate forest grouse, the Western capercaillie Tetrao urogallus, by comparing microsatellite population structure between a historic and a recent time period. We found an increase in genetic differentiation over a period of approximately 15 years. Making use of forward simulations accounting for population dynamics and genetics from both time periods, we explored future genetic differentiation by implementing scenarios of differing migration rates. Using migration rates derived from the recent dataset, simulations predicted further increase of genetic differentiation by 2050. We then examined effects of two realistic yet hypothetical migration scenarios on genetic differentiation. While isolation of a subpopulation led to overall increased genetic differentiation, the re-establishment of connectivity between two subpopulations maintained genetic differentiation at recent levels. Our results emphasize the importance of maintaining connectivity between subpopulations in order to prevent further genetic differentiation and loss of genetic variation. The simulation set-up we developed is highly adaptable and will aid researchers and conservationists alike in anticipating consequences of conservation strategies for metapopulation systems.