bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial sustainability in Malaysian public universities: coping with or embracing change?
Authors: Mamat Suaniza , Nik Ahmad Nik Nazli , Mohd Said Julia 
Published: June 2021

PurposeThis paper explores the institutionalisation of a financial sustainability agenda in Malaysian public universities.Design/methodology/approachThe study uses semi-structured interviews and document analysis. New Institutional Sociology and the institutional logics perspective are utilised to frame the study and explain findings.FindingsThe findings reveal that universities manage the conflicting academic and financial logics to co-exist to ensure legitimacy and survival. By compartmentalising the functions of key divisions and through loose coupling, universities are able to support dual logics.Research limitations/implicationsThe paper provides university management and policy makers with insights into how leading universities in Malaysia cope with a financial sustainability agenda.Originality/valueThe present study documents how universities cope with and respond to government reforms and budgetary cuts in the context of a developing country, Malaysia. Most prior research in the area focuses on individual or organisational responses. This paper examines organisational-level responses but goes deeper to understand how universities, through three key divisions; bursaries, corporate strategy divisions and faculties manage to enable the multiple logics to co-exist through compartmentalisation and loose coupling.
A deep neural network based context-aware smart epidemic surveillance in smart cities
Authors: Gill Harsuminder Kaur , Sehgal Vivek Kumar , Verma Anil Kumar 
Published: June 2021

PurposeEpidemics not only affect the public health but also are a threat to a nation's growth and economy as well. Early prediction of epidemic can be beneficial to take preventive measures and to reduce the impact of epidemic in an area.Design/methodology/approachA deep neural network (DNN) based context aware smart epidemic system has been proposed to prevent and monitor epidemic spread in a geographical area. Various neural networks (NNs) have been used: LSTM, RNN, BPNN to detect the level of disease, direction of spread of disease in a geographical area and marking the high-risk areas. Multiple DNNs collect and process various data points and these DNNs are decided based on type of data points. Output of one DNN is used by another DNN to reach to final prediction.FindingsThe experimental evaluation of the proposed framework achieved the accuracy of 87% for the synthetic dataset generated for Zika epidemic in Brazil in 2016.Originality/valueThe proposed framework is designed in a way that every data point is carefully processed and contributes to the final decision. These multiple DNNs will act as a single DNN for the end user.
Taking the therapeutic community outside in the COVID-19 pandemic
Authors: Jones Merryn , Howe Andrew John 
Published: June 2021

Purpose
The COVID-19 pandemic has affected psychotherapy practice. A common change is a move to online sessions over video calls. In their therapeutic community (TC) for those with personality disorders, the authors have used video calls but not all clients could work in this way. The authors decided to meet patients outside and walked with them while adhering to government guidelines. This study aims to present the authors’ experience with one client who was interviewed afterwards about the experience.

Design/methodology/approach
A total of 10 walking therapy sessions of 60-min duration were conducted with the patient. After the sessions, both the patient and therapist were interviewed about their experience. The resulting interviews with both patient and therapist were thematically analysed independently by both authors.

Findings
There were common themes to both the client and therapist’s account following thematic analysis. These were: modelling and normalising in the real world, replacing what COVID-19 had taken away from the TC experience, changes at home, therapist disclosure, outcomes and good endings and being outside of the clinical environment.

Research limitations/implications
The authors have presented a single case of the patient and therapist experience of outdoor therapy sessions in a TC context response to the COVID-19 pandemic. The findings are not generalisable and can only provide a suggestion at the positive potential for working in this way. The authors hope that the positive effects of outdoor therapy noted here may inspire other clinicians to consider similar novel approaches in their work.

Originality/value
This study describes a novel way that a TC has adapted to the COVID-19 pandemic.
Do not let it derail: the district head’s dilemma
Authors: Varma Harikrishnan Ramesh , Kakani Ram Kumar 
Published: June 2021

Theoretical basis
The theoretical concepts and frameworks from the following literature are brought in to discuss the case situation. Freeman’s stakeholder framework, Yukl’s Influence Tactics, Johnson and Scholes’ Power-Interest Matrix Please see: Freeman, R. E. (2010). Strategic Management: A Stakeholder Approach. Pitman Publishing Inc. Yukl, G. (2002). Leadership in Organizations. Prentice-Hall. Johnson, G. and Scholes, K. (1999). Exploring Corporate Strategy: Text and Cases. Prentice-Hall.

Research methodology
Information required for the case was primarily collected from Lal Bahadur Shastri National Academy of Administration, Mussorie, India, where the newly recruited civil service officers (probationary trainees) of India are trained. The main protagonist, a senior officer in the Indian Administrative Services was interviewed by one of the authors. Secondary data from contemporary newspaper reports and government orders were also made use of.

Case overview/synopsis
Palakkad District Magistrate Gayathri Nair was tasked with acquiring 130 hectares of land for a government-sponsored public-private partnership project to set up a railway coach factory in Palakkad. After taking the landowners into confidence and fast-tracking the administrative process through the line departments, she successfully acquired 93 hectares of land for Phase I of the project. However, the intervention from local politicians and activists halted the next phase. Gayathri was pressured by her bosses to solve the standstill in four weeks. Unable to make the owners realize the benefits of the project, she witnessed a showdown between the agitating masses and the district administration. The entire episode is worsened by the partisan media coverage. The only options open to Gayathri, as the head of the district administration, are either to go ahead with forceful land acquisition and thereby, risk the wrath of the public or abandon the project and bury the months-long back-breaking teamwork. How could Gayathri handle the situation better? What steps could she take at various stages to ensure a balanced outcome for all the stakeholders in the project?

Complexity academic level
This case is applicable for the courses/sessions in training programmes for executives, and undergraduate courses related to project management, strategic management, leadership and public policy. It is also useful for courses and training programmes on stakeholder mapping and conflict management.
Genres of waiting: patronage, healthcare, and dyadic sovereignty in Northeast Brazil
Authors: Ansell Aaron 
Published: June 2021

AbstractThis article offers an ethnographic comparison of two genres of waiting for healthcare in Northeast Brazil in order to explain the persistence of patron‐client practices at a time when people otherwise reject patronage. The explanation turns on a recasting of patronage as a form of sovereignty whereby politicians and afflicted persons may choose to suspend the emerging rights‐based care regime in favour of older patronage‐based approaches to care. Motivating such decisions is the afflicted person's experience of the wait for rights‐based healthcare as a form of ‘bare life’, an experience they hope to escape.
Treatment of opioid dependence with depot buprenorphine (CAM2038) in custodial settings
Authors: Dunlop Adrian J. , White Bethany , Roberts Jillian , Cretikos Michelle , Attalla Dena , Ling Rod , Searles Andrew , Mackson Judith , Doyle Michael F. , McEntyre Elizabeth , Attia John , Oldmeadow Christopher , Howard Mark V. , Murrell Terry , Haber Paul Steven , Lintzeris Nicholas 
Published: June 2021

AbstractBackground and aimsOpioid agonist treatment is effective but resource intensive to administer safely in custodial settings, leading to significant under‐treatment of opioid dependence in these settings world‐wide. This study assessed the safety of subcutaneous slow‐release depot buprenorphine in custody.DesignOpen‐label, non‐randomized trial.SettingCorrectional centres in New South Wales, Australia.ParticipantsSixty‐seven men and women, aged ≥ 18 years of various security classifications with a diagnosis of moderate to severe DSM‐5 opioid use disorder currently serving a custodial sentence of ≥ 6 months were recruited between November 2018 and July 2019. Patients not in opioid agonist treatment at recruitment commenced depot buprenorphine; patients already stable on oral methadone treatment were recruited to the comparison arm.Intervention and comparatorDepot buprenorphine (CAM2038 weekly for 4 weeks then monthly) and daily oral methadone.MeasurementsSafety was assessed by adverse event (AE) monitoring and physical examinations at every visit. Participants were administered a survey assessing self‐reported diversion and substance use at baseline and weeks 4 and 16.FindingsRetention in depot buprenorphine treatment was 92.3%. Ninety‐four per cent of patients reported at least one adverse event, typically mild and transient. No diversion was identified. The prevalence of self‐reported non‐prescribed opioid use among depot buprenorphine patients decreased significantly between baseline (97%) and week 16 (12%, odds ratio = 0.0035, 95% confidence interval = 0.0007–0.018, P < 0.0001).ConclusionsThis first study of depot buprenorphine in custodial settings showed treatment retention and outcomes comparable to those observed in community settings and for other opioid agonist treatment used in custodial settings, without increased risk of diversion.
The kapok tree (Ceiba pentandra (L.) Gaertn, Malvaceae) as a food source for native vertebrate species during times of resource scarcity and its potential for reforestation in Madagascar
Authors: Hending Daniel , Randrianarison Heriniaina , Holderied Marc , McCabe Grainne , Cotton Sam 
Published: June 2021

AbstractReforestation in Madagascar often relies on a few tree species with known properties. Species selection may consider aspects like human use, growth characteristics and animal use. Here, we investigated the use of the kapok tree (Ceiba pentandra) as a food source for vertebrates during the dry season in North West Madagascar. We observed 21 native vertebrate species (five lemurs, five bats and 11 birds) feed on or within C. pentandra during this period of low food availability, 48% of which are known seed dispersers. As a fast‐growing species, C. pentandra may therefore be suitable for inclusion in reforestation and forest restoration efforts to facilitate seed dispersal, natural forest regeneration and animal movement between adjacent forest fragments.
Efficacy and safety of blinatumomab: Post hoc pooled analysis in Asian adults with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia
Authors: Kobayashi Yukio , Oh Iekuni , Miyamoto Toshihiro , Lee Won‐Sik , Iida Hiroatsu , Minami Hironobu , Maeda Yoshinobu , Jang Jun Ho , Yoon Sung‐Soo , Yeh Su‐Peng , Tran Qui , Morris Joan , Franklin Janet , Kiyoi Hitoshi 
Published: June 2021

AbstractBackgroundGlobal studies have demonstrated the efficacy and safety of blinatumomab—a BiTE® (bispecific T‐cell engager) targeted immuno‐oncology therapy that mediates the lysis of cells expressing CD19 in patients with relapsed/refractory acute lymphoblastic leukemia (R/R ALL). Because limited data are available in Asian patients, we conducted a post hoc pooled analysis in 45 Asian adult patients with R/R ALL—19 from the blinatumomab arm of TOWER (NCT02013167) and 26 from Study 265, a phase 1b/2 study in Japanese adults (NCT02412306).MethodsPatients received a maximum of two cycles of induction blinatumomab for 4 weeks by continuous intravenous infusion (cycle 1/week 1: 9 μg/day; cycle 1/weeks 2–4: 28 μg/day) followed by 2 weeks of no blinatumomab (each 6‐week cycle); patients received 28 μg/day blinatumomab in subsequent cycles.ResultsTwenty of 45 patients enrolled (44%) achieved complete remission with full or partial hematologic recovery compared with 44% in TOWER and 80% and 38% in phase 1b and phase 2, respectively, of Study 265. The Kaplan–Meier (KM) median overall survival was 11.9 months (95% confidence interval [CI], 9.9–17.1) and the KM median duration of relapse‐free survival was 8.9 months (95% CI, 3.8–10.7). Ninety‐three percent of patients had grade ≥ 3 treatment‐emergent adverse events (AEs) compared with 87% in TOWER and 80% and 100% in phase 1b and phase 2, respectively, of Study 265. Five patients (11.4%) had fatal AEs.ConclusionsThe safety and efficacy of blinatumomab in Asian patients were comparable with those reported in previous global studies with no new safety signals.
A multimodal quality improvement approach to promote normothermia in very preterm infants
Authors: Young Aneurin , Azeez Fameesh , Godad Santan Pawalu , Shetty Preethish , Sharma Alok 
Published: June 2021

AbstractAimTo achieve the National Neonatal Audit Programme (NNAP) standard of 90% normothermia among preterm infants born under 30 weeks of gestation.MethodsProject SHIP (Stopping Hypothermia In Premmies) was a quality improvement programme to improve admission normothermia. Phase 1 of the project implemented low‐fidelity simulations during 2011–2016. In Phase 2 (2017), a multimodal approach to quality improvement was used, including in situ simulations, videos of simulated scenarios, an allocated team member for thermal care, a clear protocol for thermal care, a coordinating ‘lollipop man’ role and monthly performance feedback. Additionally, continuous temperature monitoring using servo‐control during stabilisation was introduced during Phase 2. Phase 3 (2018–2019) focused on embedding practice and maintaining performance.ResultsPhase 1 initiatives resulted in improvement of normothermia rates from 58% to 75%. However, the results plateaued. During Phase 2, the hypothermia rate fell from 16% to 3%. During Phase 3, this improvement in the hypothermia rate was sustained, achieving the standard of 90% normothermia in 2018 and falling just short in 2019 due to an increased hyperthermia rate.ConclusionA multimodal quality improvement approach achieved sustained improvement in normothermia. Continuous temperature monitoring during stabilisation allows resuscitating teams to plan interventions to treat hypothermia and hyperthermia.
The politics of identity: The unexpected role of political orientation on racial categorizations of Kamala Harris
Authors: Ma Debbie S. , Hohl Danita , Kantner Justin 
Published: June 2021

AbstractThe 2020 US Presidential election was historic in that it featured the first woman of color, Kamala Harris, on a major‐party ticket. Although Harris identifies as Black, her racial identity was widely scrutinized throughout the election, due to her mixed‐race ancestry. Moreover, media coverage of Harris's racial identity appeared to vary based on that news outlet's political leaning and sometimes had prejudicial undertones. The current research investigated racial categorization of Harris and the role that political orientation and anti‐Black prejudice might play in shaping these categorizations. Studies 1 and 2 tested the possibility that conservatives and liberals might mentally represent Harris differently, which we hypothesized would lead the two groups to differ in how they categorized her race. Contrary to our prediction, conservatives, and liberals mentally represented Harris similarly. Also surprising were the explicit racial categorization data. Conservatives labeled Harris as White more than liberals, who tended to categorize Harris as multiracial. This pattern was explained by anti‐Black prejudice. Study 3 examined a potential political motivation that might explain this finding. We found that conservatives, more than liberals, judge having a non‐White candidate on a Democratic ballot as an asset, which may lead conservatives to deny non‐White candidates these identities.
Inattention, hyperactivity/impulsivity, and academic competence: Findings from three cohorts
Authors: Tan Tony Xing , Liu Yanhong , Damjanovic Victoria , Ledford Elyse , Li Gen , Li Yanzheng 
Published: June 2021

BackgroundAttention‐deficit hyperactivity disorder (ADHD) is a risk for learning. Because ADHD commonly includes behaviours of inattention and behaviours of hyperactivity/impulsivity, how the two types of behaviours independently affect children’s academic competence remains poorly understood.AimsTo investigate the impact of behaviours of inattention and behaviours of hyperactivity/impulsivity on Chinese students’ academic competence.SamplesParents of 167 preschoolers (Cohort 1), parents of 313 first graders (Cohort 2), and 1,003 high school students (Cohort 3).MethodsThe ADHD‐RS‐IV Preschool version (Cohort 1), ADHD‐RS‐IV Home version (Cohort 2), and BASC‐SRP (Cohort 3) were used to measure behaviours of inattention and hyperactivity/impulsivity. Academic competence was operationalized as school readiness (Cohort 1), math and language arts scores at two time points provided by school (Cohort 2), and self‐reported academic performance (Cohort 3). Multiple regressions were performed to investigate the relationship between academic performance and behaviours of inattention alone (Step 1), and behaviours of hyperactivity/impulsivity alone (Step 2), and behaviours of inattention together with behaviours of hyperactivity/impulsivity (Step 3).ResultsFor each cohort, both types of behaviours were negatively correlated with academic competence. However, regression analyses showed that in Step 3, behaviours of hyperactivity/impulsivity either failed to predict academic competence or predicted better academic competence. Overall, behaviours of inattention alone accounted for a similar amount of variance in academic competence as did behaviours of inattention and hyperactivity/impulsivity combined.ConclusionsBehaviours of inattention presented a risk for academic competence but the effect of behaviours of hyperactivity/impulsivity varied. Implications for instructional strategies for behaviours of inattention were discussed.
Towards a druggable epitranscriptome: Compounds that target RNA modifications in cancer
Authors: Berdasco María , Esteller Manel 
Published: June 2021

Epitranscriptomics is an exciting emerging area that studies biochemical modifications of RNA. The field has been opened up by the technical efforts of the last decade to characterize and quantify RNA modifications, and this has led to a map of post‐transcriptional RNA marks in normal cell fate and development. However, the scientific interest has been fuelled by the discovery of aberrant epitranscriptomes associated with human diseases, mainly cancer. The challenge is now to see whether epitrancriptomics offers mechanisms that can be effectively targeted by low MW compounds and are thus druggable. In this review, we will describe the principal RNA modifications (with a focus on mRNA), summarize the latest scientific evidence of their dysregulation in cancer and provide an overview of the state‐of‐the‐art drug discovery to target the epitranscriptome. Finally, we will discuss the principal challenges in the field of chemical biology and drug development to increase the potential of targeted‐RNA for clinical benefit.LINKED ARTICLESThis article is part of a themed issue on New avenues in cancer prevention and treatment (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.12/issuetoc
Outcomes of 756 patients with differentiated thyroid cancer and excellent response to treatment: An evidence‐based paradigm for long‐term surveillance strategies
Authors: Seejore Khyatisha , Mulla Omar , Gerrard Georgina E. , Gill Vanessa M. , Al‐Qaissi Ahmed , Moor James W. , Murray Robert D. 
Published: June 2021

AbstractBackgroundThe 2014 British Thyroid Association thyroid cancer guidelines recommend lifelong follow‐up of all thyroid cancer patients. This is probably unnecessary, particularly for differentiated thyroid cancer (DTC) patients with an excellent response to treatment and places significant demand on health service resources.DesignSingle centre retrospective cohort analysis of patients diagnosed and treated at the Leeds Cancer Centre between 2001 and 2014.PatientsA total of 756 patients were dynamically risk‐stratified (DRS) as having ‘excellent response to treatment’ after total thyroidectomy and radioiodineremnant ablation (RRA) for DTC.ResultsMedian follow‐up was 11.2 (range: 6.5–18.5) years. Radiological recurrence occurred in 15/756 (2.0%) patients and was always preceded by a raised thyroglobulin or thyroglobulin antibody level. The vast majority of tumour recurrences (13/15, 85%) were identifiable within 5 years of diagnostic surgery. Patients classified as having high‐risk disease as per American Thyroid Association (ATA) guidelines had an almost threefold higher recurrence rate (2/34 [5.9%] vs. 13/722 [1.8%]) than those with ATA low‐risk or intermediate‐risk disease. Tumour histology subtype was a significant contributing factor, with Hürthle cell cancer having a worse prognosis than papillary thyroid cancer (PTC) (5/68 [7.4%] vs. 9/582 [1.5%]; relative risk: 4.76 [95% confidence interval: 1.64–13.8]).ConclusionsThe recurrence rate of DRS patients with excellent response to treatment is low. It is reasonable to consider discharge of ATA low‐risk or intermediate‐risk patients with PTC who remain disease‐free after 5 years of secondary care follow‐up. Lifelong follow‐up, however, currently remains the standard for subgroups at greater risk.
Noonan syndrome‐like phenotype in a patient with heterozygous ERF truncating variant
Authors: Yamada Mamiko , Funato Michinori , Kondo Goro , Suzuki Hisato , Uehara Tomoko , Takenouchi Toshiki , Sakamoto Yoshiaki , Kosaki Kenjiro 
Published: June 2021

AbstractCraniosynostosis is caused by abnormalities of multiple signaling pathways, including excessive RAS signaling. Recently, a truncating variant in ETS2 repressor factor (ERF), a negative transcriptional regulator of the RAS pathway, was shown to be associated with craniosynostosis. Here, we report a 10‐year‐old male patient with a heterozygous nonsense mutation, p.Arg183*, in ERF who exhibited craniosynostosis with Noonan syndrome‐like phenotypes. In consideration that loss‐of‐function variants in ERF would result in excessive RAS signaling and RASopathy phenotypes, we propose that ERF may represent a causative gene for Noonan syndrome. Since preceding studies on ERF mutations dealt with patients who were ascertained because of craniosynostosis, further studies are needed to evaluate whether patients with variants in ERF can present with Noonan syndrome‐like features without craniosynostosis.