bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANÁLISIS DE LA ECONOMÍA COLABORATIVA EN EL TURISMO URBANO. ESTUDIO DE LA IMPLANTACIÓN DE AIRBNB EN MADRID Y BARCELONA
Authors: Cerdá Mansilla Elena , García Henche Blanca , Such Devesa María Jesús 
Published: June 2021

El presente artículo pretende contribuir a la investigación de los modelos de gestión urbana considerando la economía colaborativa, añadiendo una perspectiva integradora que evalúa el impacto real en el territorio de los alojamientos reglados y no reglados en las ciudades, con el fin de garantizar la sostenibilidad de los destinos a largo plazo, la experiencia del turista y la calidad de vida de los residentes.
Se analizan los datos de los hoteles y los apartamentos turísticos junto con los de Airbnb y se cartografía la distribución de los nuevos indicadores capaces de reflejar la situación real que están experimentado la demanda y la oferta alojativa en Madrid y Barcelona.
Gracias a esos indicadores se podrá aproximar una medición real de la economía colaborativa para garantizar la sostenibilidad de los destinos turísticos.
This paper seeks to contribute to the investigation of urban management models considering the sharing economy. Adding an integrative perspective that evaluates the real impact on the territory of regulated and unregulated accommodation in cities in order to guarantee the sustainability of the long-term destinations, the tourist experience and the quality of life of the residents.
The data of the hotels and tourist apartments are analyzed together with those of Airbnb. The data of the distribution of holiday dwellings offered by Airbnb were mapped out as new indicators capable of reflecting the real situation that demand and housing supply are experiencing in Madrid and Barcelona.
It is understood that thanks to these indicators, tourist destinations are able to direct exchanges between collaborative economy and smart economy toward achieving the purpose of the model: making destinations sustainable.
Effect of Treated Sewage Water Irrigation on Yield and Quality of Mulberry
Authors: Kumar M. Arun , Chandrashekhar S. 
Published: June 2021

Aim: Evaluation of raw and treated sewage water irrigation on yield and quality of V1 mulberry.
Study design: The Experiment was laid out in a Randomized Complete Block Design (RCBD) with four replications and six treatments comprises of different proportions of raw sewage water, treated sewage water and borewell water.
Place and duration of study: The study was conducted during Rabi 2019 in pre-established irrigated V1 mulberry garden at Department of Sericulture, University of Agricultural Sciences, GKVK, Bengaluru, Karnataka, India.
Results: Data recorded on quality parameters of mulberry revealed that raw sewage water irrigation significantly increased the leaf nutrient content such as N (3.68%), P (0.4%), K(1.91%), S (0.34%), Zn (30.08 ppm), Mn (103.75 ppm), Fe (373.75 ppm) and also leaf yield (804.31 g/plant) is significantly increased in 100% raw sewage water irrigation, whereas higher leaf Ca (2.06%) and Mg (0.71%) content was recorded in 100% borewell water irrigated plot, and the lowest leaf N (2.82%), P (0.28%), K (1.33%), S (0.17%), Zn (18.03 ppm), Mn (75.75 ppm), and Fe (336.5 ppm) content was found lower in 100% borewell water irrigation.
Phytochemical Analysis and Antioxidants effects of Methanol Stem Bark Extract of Eucalyptus Camaldulensis in Wister Albino Rats
Authors: Nwaogu Jude , Abubakar Babangida , Aliyu Mustapha Sahabi 
Published: June 2021

Aim: The aim is to evaluate the antioxidant potentials of Eucalyptus camaldulensis methanol stem bark extract (ECMSBE) on Wister albino rats.
Methodology: The phytochemical screening of ECMSBE was conducted using standard methods. A total of 36 albino rats were used for the antioxidant studies. The rats were divided into six (6) groups of six rats. Control group received distilled water orally at 2ml/kg. Oxidative stress was induced in groups 2 to group 6 CCl4 (1ml/kg, s.c) at every 72hrs for 10 days. Group 2 was untreated while groups 3 – 6 received doses of 50, 100, 150 and 200mg/kg of ECMSBE respectively. On the 11th day, the rats were sacrificed and the liver was removed and homogenised and oxidative stress parameters were determined.
Results: Phytochemical analysis of ECMSBE revealed the presence of saponins, flavonoids, tannins, phenols, glycosides, steroids, terpenoids and resins. There was no significant difference (P<.05) between the CCl4 induced group and the group treated with ECMSBE (50mg/kg). However, their concentrations were significantly different from the group treated with ECMSBE (100mg/kg – 200mg/kg) when compared to the group treated with CCl4 Only. The CCl4-induced group had its vitamin A, vitamin C and vitamin E concentrations significant different (P<.05) from the groups treated with ECMSBE (100, 150 and 200mg/kg body weight). There was no significant difference (P>.05) in the levels of SOD, CAT and GPx between the group induced with CCl4 only and the group treated with ECMSBE (50mg/kg), however, it these concentrations were significantly higher (P<.05). The enzymatic antioxidants concentration in the normal control group was not significantly different (P>.05) when compared the group that was treated with ECMSBE (200mg/kg)
Conclusion: The result suggest that the extract of E. camaldulensis possessed antioxidant properties which can be used as effective protecting agents against oxidative stress and other diseases.
The PD‐1 Interactome
Authors: Wang Qi , Bardhan Kankana , Boussiotis Vassiliki A. , Patsoukis Nikolaos 
Published: June 2021

AbstractT cell activation is a fine‐tuned process that involves T cell receptor and costimulation signals. To prevent undue activation of T cells, inhibitory molecules including PD‐1 (programmed death 1) are induced and function as brakes for T cell signaling. In a steady state, the interaction of PD‐1 with its ligands PD‐L1 (B7‐H1, CD274) and PD‐L2 (B7‐DC, CD273) maintains peripheral immune tolerance. However, the expression of PD‐L1 on tumor cells and interaction with PD‐1 on T cells dampen anti‐tumor immunity. Therapeutic inhibitors of the PD‐1 pathway have revolutionized tumor immunotherapy. Unfortunately, the majority of patients do not develop sustained anti‐tumor responses. However, the knowledge about unique PD‐1 interactions and their role in mediating PD‐1 inhibitory signals is currently limited. Advances in the mechanistic understanding of the molecular and signaling integration of the PD‐1 pathway could unleash the great potential in tumor immunotherapy by allowing the development of combinatorial approaches that target not only PD‐1 and its ligands but also its unique downstream signal mediators. In this review, the current advances in understanding the mechanisms of extracellular and intracellular PD‐1 interactions and their significance in potential future therapeutic approaches are discussed.
A New Wide Bandgap Semiconductor: Carbyne Nanocrystals
Authors: Yang Fei , Zheng Zhaoqiang , He Yan , Liu Pu , Yang Guowei 
Published: June 2021

AbstractDeep ultraviolet (DUV) photodetectors (PDs) always and inevitably face a drastic working environment such as high temperature. However, DUV PDs based on the reported wide bandgap semiconductor materials cannot simultaneously possess high stability and high performance at high temperatures. Here, for the first time, a new wide bandgap semiconductor material, carbyne nanocrystals (CNCs), is reported. The constructed DUV PD made from CNCs demonstrates high‐performance and high stability at the temperature of 300 °C, which is the highest working temperature reported to date for DUV PDs. Under 266 nm light at room temperature, the CNCs‐based PD exhibits a low dark current of less than 10 pA and a high signal‐to‐noise ratio of greater than 106 at a bias voltage of 2 V. It can work at the temperature up to 300 °C, exhibiting a current on‐off ratio of 2.1, and accompanied by a fast response/recovery speed of less than 0.06 s. The excellent transport properties of CNCs would be of great benefit to enhance the performance of devices. These findings open the door to the applications of CNCs as a new wide bandgap semiconductor material.
Synthesis of clay‐armored coatable sulfonated polyimide nanocomposites as robust polyelectrolyte membranes
Authors: Ali Nisar , Ali Farman , Said Amir , Khurshid Sania , Sheikh Zeshan Ali , Ali Usman , Nguyen‐Tri Phuong , Bilal Muhammad 
Published: June 2021

AbstractHerein, coatable sulfonated polyimide (SPI) and clay‐reinforced SPI membranes SPI‐clay 3%, SPI‐clay 5%, and SPI‐clay 7% were successfully fabricated by one‐step high temperature via direct imidization method. The membranes were cast as a coatable thin film using a solution casting method and grafted vermiculite clay nanoparticle were incorporated into the neat SPI as reinforcement by the sonication method. Three different formulated nanocomposite membranes were investigated using different characterization techniques such as Fourier transform infrared spectroscopy as peaks at 1166 and 1227 cm−1 confirmed successful sulfonation. In Proton (1H) NMR synthesis of SPI confirmed as aromatic proton at 7.3–8.8 ppm depicts successful sulfonation and X‐ray diffraction results confirmed the crystalline structure of clay, as its content increased (7%) clear diffraction peak arises at 6 and 25°. Scanning electron microscopy (SEM) provides information about surface morphology of clay reinforced SPI membranes, and SEM micrographs shown uniform dispersion of clay nanofillers and developed easy transfer of electron. Thermogravimetric analysis was performed to investigate the thermal stability of synthesized films, results of thermographs shown degradation in the range of 510–600°C. Different physicochemical parameters employed and their results show the effectiveness of synthesized clay reinforced SPI membranes. Water uptake (WU%) about 0.96%, hydrolytic about 98 h and oxidative stability up to 80°C, ions exchange capacity about 3.16 mmol/g for synthesized clay reinforced SPI membranes. Measurement regarding Dimensional changes was also investigated and dimensional changes (1.557 ∆t/∆l). All these results reveal that the clay‐reinforced coatable SPI membranes are a promising material for polymer electrolyte membranes to be used in fuel cell energy applications.
Video counselling and psychotherapy: A critical commentary on the evidence base
Authors: Smith Kate , Moller Naomi , Cooper Mick , Gabriel Lynne , Roddy Jeannette , Sheehy Robert 
Published: June 2021

AbstractPre‐pandemic research has suggested that video counselling is as effective as face‐to‐face practice. However, the mass migration of therapy to the online video domain as a result of the COVID‐19 pandemic makes it essential to interrogate the evidence base. This paper provides a critical commentary on how video therapy is defined/labelled, the current evidence about whether video therapy is effective, and whether the working alliance and therapeutic relationship functions differently in video counselling. The paper concludes that while the evidence to date is promising, it is limited in quantity and applicability and hence generalisability. Lack of evidence is not evidence that video therapy is ineffective, but the large gaps in understanding highlight the importance, both ethically and empirically, of further research in this area.
Identification and characterization of effusion tumor cells (ETCs) from remnant pleural effusion specimens
Authors: Zhu Yili , Allard Grace M. , Ericson Nolan G. , George Tad C. , Kunder Christian A. , Lowe Alarice C. 
Published: June 2021

BackgroundCancer is a leading cause of death worldwide, and patients may have advanced disease when diagnosed. Targeted therapies guided by molecular subtyping of cancer can benefit patients significantly. Pleural effusions are frequently observed in patients with metastatic cancer and are routinely removed for therapeutic purposes; however, effusion specimens have not been recognized as typical substrates for clinical molecular testing because of frequent low tumor cellularity.MethodsExcess remnant pleural effusion samples (N = 25) from 21 patients with and without suspected malignancy were collected at Stanford Health Care between December 2019 and November 2020. Samples were processed into ThinPrep slides and underwent novel effusion tumor cell (ETC) analysis. The ETC results were compared with the original clinical diagnoses for accuracy. A subset of confirmed ETCs was further isolated and processed for molecular profiling to identify cancer driver mutations. All samples were obtained with Institutional Review Board approval.ResultsThe authors established novel quantitative standards to identify ETCs and detected epithelial malignancy with 89.5% sensitivity and 100% specificity in the pleural effusion samples. Molecular profiling of confirmed ETCs (pools of 5 cells evaluated) revealed key pathogenic mutations consistent with clinical molecular findings.ConclusionsIn this study, the authors developed a novel ETC‐testing assay that detected epithelial malignancies in pleural effusions with high sensitivity and specificity. Molecular profiling of 5 ETCs showed promising concordance with the clinical molecular findings. To promote cancer subtyping and guide treatment, this ETC‐testing assay will need to be validated in larger patient cohorts to facilitate integration into cytologic workflow.
Newton method for computing the adaptation coefficient in the CIE system of mesopic photometry
Authors: Xu Yang , Gao Cheng , Wang Zhifeng , Xiao Kaida , Pointer Michael , Li Changjun 
Published: June 2021

AbstractA study by Gao et al found that the Newton method may not converge for certain combinations of the photopic luminance and the ratio of scotopic and photopic luminance for computing the adaptation coefficient m, for the CIE MES2 system for mesopic photometry. Hence, they proposed to use the Bisection‐Newton method. In this short note, we propose the Newton method with a new initial guess for computing m. Numerical simulation has shown the proposed method not only converges, but also converges faster than the Bisection‐Newton method.
A Neuroscientist's Guide to the Vole
Authors: Kenkel William M. , Gustison Morgan L. , Beery Annaliese K. 
Published: June 2021

AbstractPrairie voles have emerged as an important rodent model for understanding the neuroscience of social behavior. Prairie voles are well known for their capacity for pair bonding and alloparental care. These behavioral phenomena overlap with human social behavior but are not commonly observed in traditional rodent models. In this article, we highlight the many benefits of using prairie voles in neuroscience research. We begin by describing the advantages of using diverse and non‐traditional study models. We then focus on social behaviors, including pair bonding, alloparental care, and peer interactions, that have brought voles to the forefront of social neuroscience. We describe many additional features of prairie vole biology and behavior that provide researchers with opportunities to address an array of research questions. We also survey neuroethological methods that have been used with prairie voles, from classic to modern techniques. Finally, we conclude with a discussion of other vole species, particularly meadow voles, and their own unique advantages for neuroscience studies. This article provides a foundation for researchers who are new to working with voles, as well as for experienced neuroscientists who want to expand their research scope. © 2021 Wiley Periodicals LLC.This article was corrected on 2 August 2022. See the end of the full text for details.
Hydromorphological assessment of Polish lakes: Elaborating the Lake Habitat Survey for Polish Lakes (LHS_PL) method and determining ecologically based boundary values for lake classification
Authors: Kutyła Sebastian , Soszka Hanna , Kolada Agnieszka K. 
Published: June 2021

AbstractThe Lake Habitat Survey for Polish Lakes (LHS_PL) is a method for the hydromorphological investigation of lakes employed for the assessment of the ecological status of surface water bodies in Poland. It was developed based on the British Lake Habitat Survey method. In 2015, after almost a decade of work on the adaptation, the LHS method was finally adjusted to Polish conditions, and since 2016, it has been implemented in the State Environmental Monitoring programme. This paper presents the assumptions and evolution of the method and the approach for determining boundary values for the high/good (H/G) and good/less than good (G/LTG) ecological status classes. The method involves the assessment of the morphological features of the lake and anthropogenic pressures at 10 observation plots as well as the analysis of hydrological alterations and anthropogenic activities within the lake basin and the entire catchment area. The data collected in the field are used to calculate the index of lake hydromorphological alteration, that is, the Lake Habitat Modification Score for Polish Lakes (LHMS_PL). The LHMS_PL values range from 0 to 144, where 0 means no modification and 144 refers to a hydromorphologically highly modified state. The boundary values for the H/G and G/LTG status classes have been determined using the quartile method based on the relationship between hydromorphological modifications of lakes and the condition of the phytoplankton and macrophyte communities therein.
The vertical heterogeneity of soil detachment by overland flow on the water‐level fluctuation zone slope in the Three Gorges Reservoir, China
Authors: Guo Ping , Xiao Hai , Gao Feng , Li Zijuan , Hu Huan , Zhang Qianheng , Xia Zhenyao , Li Mingyi , Yang Yueshu 
Published: June 2021

AbstractPeriodic submersion and exposure due to the operation of the Three Gorges Reservoir (TGR) alter the soil properties and plant characteristics at different elevations within the water level fluctuation zone (WLFZ), possibly influencing the soil detachment capacity (Dc), but the vertical heterogeneity of this effect is uncertain. Soil samples were taken from 6 elevation segments (5 m per segment) along a slope profile in the WLFZ of the TGR to clarify the vertical heterogeneity of Dc. Scouring experiments were conducted at 5 slope gradients (17.6%, 26.8%, 36.4%, 46.6%, and 57.7%) and 5 flow rates (10, 15, 20, 25, and 30 L min−1) to determine Dc. The results indicate that the soil properties and biomass parameters of the WLFZ exhibit strongly vertical heterogeneity. Dc fluctuates with increasing elevation, with maximum and minimum average values at elevations of 145–150 m and 165–170 m, respectively. Linear equations accurately describe the relationships between Dc and hydrodynamic parameters, for which the shear stress (τ), stream power (ω), and unit energy of water‐carrying section (E) perform much better than the unit stream power (U). Furthermore, a clear improvement is achieved when using a general index of flow intensity to estimate Dc. Furthermore, Dc is significantly and negatively correlated with the mean weight diameter (MWD, p < 0.05) and organic matter content (p < 0.01) but not significantly correlated with other soil properties (p > 0.05). The rill erodibility at elevations of 145–150 m and 170–175 m is greater than that at other elevations. The critical hydraulic parameters were highest in the 165–170 m segments. Both the rill erodibility and the critical parameters fluctuate vertically along the sloping surface. This research highlights the vertical heterogeneity of Dc and is helpful for better understanding the mechanisms responsible for soil detachment in the WLFZ of the TGR.
Xanthohumol from Hop: Hope for cancer prevention and treatment
Authors: Girisa Sosmitha , Saikia Queen , Bordoloi Devivasha , Banik Kishore , Monisha Javadi , Daimary Uzini Devi , Verma Elika , Ahn Kwang Seok , Kunnumakkara Ajaikumar B. 
Published: June 2021

AbstractCancer is a major public health concern due to high mortality and poor quality of life of patients. Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause several adverse side effects. The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative strategies for the prevention and treatment of this disease. Xanthohumol (XN), a prenylated chalcone present in Hop (Humulus lupulus), has been found to possess prominent activities against aging, diabetes, inflammation, microbial infection, and cancer. Thus, this manuscript thoroughly reviews the literature on the anti‐cancer properties of XN and its various molecular targets. XN was found to exert its inhibitory effect on the growth and proliferation of cancer cells via modulation of multiple signaling pathways such as Akt, AMPK, ERK, IGFBP2, NF‐κB, and STAT3, and also modulates various proteins such as Notch1, caspases, MMPs, Bcl‐2, cyclin D1, oxidative stress markers, tumor‐suppressor proteins, and miRNAs. Thus, these reports suggest that XN possesses enormous therapeutic potential against various cancers and could be potentially used as a multi‐targeted anti‐cancer agent with minimal adverse effects.
Persistence of symptoms after improvement of acute COVID19 infection, a longitudinal study
Authors: Abdelrahman Mona Mohammed , Abd‐Elrahman Noha Mohammed , Bakheet Tasneem Mohammed 
Published: June 2021

AbstractWith the number of coronavirus disease 2019 (COVID‐19) infected patients increasing all over the world, a large number of survivors have reported changes in their quality of life or experienced re‐infection. So, we aimed to detect the percentage, type, and risk factors of persistent symptoms after improvement from acute COVID‐19 infection and to detect the percentage of COVID‐19 re‐infection and degree of severity of the second infection. One hundred seventy‐two (59 male, 113 female) patients who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) were followed up via mobile phone every 2 months for 8 to 10 months. After recovery, 105 patients (61%) (30 male, 75 female) reported one or more COVID‐19 persistent symptoms. Fatigue, dyspnea, and depression were the most common persistent symptoms representing 37.3%, 22%, 22%, respectively. We found that age was independently related to the persistence of symptoms. During the follow‐up, six females (3.5%) had laboratory‐confirmed COVID‐19 re‐infection. Their mean age was 35.7 ± 11 years. The mean interval from the complete recovery of the first infection to the onset of the second one was 53 ± 22.2 days and ranged from 30 to 90 days. The second infection was milder in severity than the first infection in 83.33% of cases. There was a high percentage of patients who complained of persistent symptoms after recovery from COVID‐19. Fatigue and headache were the most common persistent symptoms. Age was considered a risk factor for persistent symptoms. Re‐infection with SARS‐CoV‐2 can occur after recovery.