bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness of genetic counseling and genetic testing for hereditary gynecologic cancers among Korean healthcare providers: A survey
Authors: Kim Miseon , Cheol Lim Myong , Ji Nam Eun , Huang Dan , Kim Sue , Jong Yoo Heon , Lee Yoo‐Young , Chang Yoon‐Jung ,   on the behalf of the sub‐committee of Hereditary Gynecologic Cancers in the Korean Society of Gynecologic Oncology (KSGO)
Published: October 2021

AbstractWe conducted a survey to evaluate the awareness of genetic counseling and testing for hereditary gynecologic cancers among Korean healthcare providers. We performed an on‐the‐spot survey using 29 questions on respondents’ basic information, awareness of pre/post‐test genetic counseling, genetic information management, and related social issues. We surveyed healthcare providers who attended the 2019 Hereditary Gynecologic Cancer Symposium organized by the Korean Society of Gynecologic Oncology. Of the 108 attendees, 85 (78.7%) participated in the survey. Among them, 45% (37/83) and 40% (33/83) did not have a separate clinic and had a dedicated team for genetic counseling in their institutions, respectively. Most respondents (60/76, 79%) recommended genetic testing for all women diagnosed with epithelial ovarian cancer. Many respondents simultaneously (20/85, 24%) or sequentially (45/85, 53%) tested for both pathogenic somatic and germline variants, whereas a few respondents (2/85, 2%) checked for only pathogenic somatic variants using tissue samples. Only 20% (17/85) of the respondents recommended genetic testing for all women with endometrial cancer; meanwhile, 68% (58/86) offered the test based on the results of the screening test or family history. Risk‐reducing salpingo‐oophorectomy was recommended to unaffected women with pathogenic BRCA1/2 variants by 69.4% of the respondents (59/85). Most respondents (73/85, 85.9%) needed a manual on bioethics law; a few required a clinical update of hereditary cancer (73/85, 85.9%). The awareness of genetic counseling and testing and the pattern of clinical practice for hereditary gynecologic cancers differ among institutions and regions in Korea. A discussion on these issues and the development of an integrated manual for healthcare providers are required.
A New Reporting System for Diagnosis of Hepatocellular Carcinoma in Chronic Hepatitis B With Clinical and Gadoxetic Acid‐Enhanced MRI Features
Authors: Hwang Shin Hye , Hong Seung Baek , Han Kyunghwa , Seo Nieun , Choi Jin‐Young , Lee Jei Hee , Park Sumi , Lim Young‐Suk , Kim Do Young , Kim So Yeon , Park Mi‐Suk 
Published: October 2021

BackgroundCurrent major guidelines for diagnosis of hepatocellular carcinoma (HCC) based on imaging findings are different from each other and do not include clinical risk factors as a diagnostic criteria.PurposeTo developed and validated a new diagnostic score system using MRI and clinical features as applied in chronic hepatitis B patients.Study TypeRetrospective observational study.SubjectA total of 418 treatment‐naïve patients (out of 902 patients) with chronic hepatitis B having 556 lesions suspected for HCC which were eligible for curative treatment.Field Strength/sequenceT1W GRE in‐ and opposed‐phase, T2W FSE, DWI, and T1W 3D‐GRE dynamic contrast‐enhanced sequences at 1.5  T and 3  T.AssessmentSix radiologists with 7–22 years of experience independently evaluated MR images based on Liver Imaging Reporting and Data System (LI‐RADS) version 2018.Statistical TestsBased on logistic regression analysis of MRI features and clinical factors, a risk score system was devised in derivation cohorts (268 patients, 352 lesions) and externally validated (150 patients, 204 lesions). The performance of the new score system was assessed by Harell's c‐index. Using cutoff value of 12, maintaining positive predictive value ≥95%, the diagnostic performances of the score system were compared with those of LR‐5.ResultsThe 15‐point diagnostic scoring system used MRI features (lesion size, nonrim arterial phase hyperenhancement, portal venous phase hypointensity, hepatobiliary phase hypointensity, and diffusion restriction) and clinical factors (alpha‐fetoprotein and platelet). It showed good discrimination in the derivation (c‐index, 0.946) and validation cohorts (c‐index, 0.907). Using a risk score of 12 as a cut‐off, this system yielded higher sensitivity than LR‐5 (derivation cohort, 76.8% vs. 52.1%; validation cohort, 73.4% vs. 49.5%) without significant decrease in specificity (derivation cohort, 93.1% vs. 97.2%, P = 0.074; validation cohort, 91.7% vs. 96.1%, P = 0.299).Data ConclusionA new score system showed improved sensitivity in chronic hepatitis B patients compared to LI‐RADS without significant compromise in specificity.Evidence Level3Technical EfficacyStage 2.
Strengthening supply chain resilience during COVID‐19: A case study of JD.com
Authors: Shen Zuojun Max , Sun Yiqi 
Published: October 2021

AbstractThe coronavirus/SARS‐CoV‐2 (COVID‐19) outbreak has caused severe supply chain disruptions in practically all industries worldwide. Online e‐commerce platforms, which interact directly with various industries and service numerous consumers, have become remarkable interfaces to observe the impacts of the pandemic on supply chains. Using quantitative operational data obtained from JD.com https://www.jd.com., this study analyzes the impact of the pandemic on supply chain resilience, summarizes the challenging scenarios that retailing supply chains experienced in China, and presents the practical response of JD.com throughout the pandemic. To summarize, the pandemic caused exceptional demand and severe logistical disruptions in China, and JD.com has handled well its supply chain management in response based on its integrated supply chain structure and comprehensive intelligent platforms. In particular, the existing intelligent platforms and the delivery procedures were modified slightly but promptly to deal with specific disruptions. Moreover, the entire market scenario in China was effectively controlled through the joint efforts of multiple firms, the government, and the entire Chinese society. Our study provides an example of using practical operational indicators to analyze supply chain resilience, and suggests firms pay attention to operational flexibility and collaboration beyond supply chains to deal with a large‐scale supply chain disruption, such as the COVID‐19 outbreak.
Investigation of multiple populations highlight VEGFA polymorphisms to modulate anterior cruciate ligament injury
Authors: Feldmann Daneil C. , Rahim Masouda , Suijkerbuijk Mathijs A. M. , Laguette Mary‐Jessica N. , Cieszczyk Paweł , Ficek Krzysztof , Huminska‐Lisowska Kinga , Häger Charlotte K. , Stattin Evalena , Nilsson Kjell G. , Alvarez‐Rumero Javier , Eynon Nir , Feller Julian , Tirosh Oren , Posthumus Michael , Chimusa Emile R. , Collins Malcolm , September Alison V. 
Published: October 2021

AbstractPolymorphisms in VEGFA and KDR encoding proteins have been associated with anterior cruciate ligament (ACL) injury risk. We leveraged a collective sample from Sweden, Poland, and Australia to investigate the association of functional polymorphisms in VEGFA and KDR with susceptibility to ACL injury risk. Using a case–control genetic association approach, polymorphisms in VEGFA and KDR were genotyped and haplotypes inferred from 765 controls, and 912 cases clinically diagnosed with ACL rupture. For VEGFA, there was a significant overrepresentation of the rs2010963 CC genotype (p = 0.0001, false discovery rate [FDR]: p = 0.001, odds ratio [OR]: 2.16, 95% confidence interval [CI]: 1.47–3.19) in the combined ACL group (18%) compared to the combined control group (11%). The VEGFA (rs699947 C/A, rs1570360 G/A, rs2010963 G/C) A‐A‐G haplotype was significantly (p = 0.010, OR: 0.85, 95% CI: 0.69–1.05) underrepresented in the combined ACL group (23%) compared to the combined control group (28%). In addition, the A‐G‐G construct was significantly (p = 0.036, OR: 0.81, 95% CI: 0.64–1.02) underrepresented in the combined ACL group (12%) compared to the combined CON group (16%). Our findings support the association of the VEGFA rs2010963 CC genotype with increased risk and (ii) the VEGFA A‐A‐G haplotype with a reduced risk, and are in alignment with the a priori hypothesis. Collectively identifying a genetic interval within VEGFA to be implicated in ACL risk modulation and highlight further the importance of vascular regulation in ligament biology.
Establishing a recommended duration of blood glucose monitoring in nondiabetic patients following orthopaedic surgery
Authors: O'Brien Todd M. , Hosseinzadeh Shayan , Chen Antonia F. , Verrier Kimberly I. , Melnic Christopher M. , Humphrey Tyler J. , Bedair Hany S. 
Published: October 2021

AbstractPrevious studies have demonstrated that blood glucose (BG) levels should be monitored for at least 1 week after orthopaedic surgery in diabetic patients, but no study has determined how long nondiabetic patients should be monitored. As postoperative elevations in BG have deleterious effects, determining a duration for monitoring the BG of nondiabetic patients after major orthopaedic surgery is needed to detect hyperglycemic events, create comprehensive protocols for nondiabetic orthopaedic patients, and reduce adverse outcomes. A retrospective study was conducted including consecutive patients who underwent a major orthopaedic surgery at a community hospital. A BG level of 150 mg/dl was the cutoff used to define hyperglycemia according to our institutional guidelines. A χ2, analysis of variance, and subgroup analysis were performed separately. Greater than 67% of nondiabetic patients experienced a high BG level (>150 mg/dl) after surgery. We found that nondiabetic patients reached their postoperative maximum BG level at 20 h, which was sooner compared to diabetic patients. We discovered more than 92% of nondiabetic patients reached a maximum BG levels within the first 72 h of hospitalization, while the BG levels after this period were found to be within normal limits in greater than 87% of cases. We propose that BG management be instituted in nondiabetics from the preoperative period to 72 h after surgery, including patients who are same‐day discharges. There may not be a need to continue inpatient BG monitoring beyond the first 72 h for nondiabetic hospitalized patients with extended hospitalizations.
Horashim East: a newly discovered Middle Palaeolithic site in central Israel
Authors: Assaf Ella , Slon Viviane , Romagnoli Francesca 
Published: October 2021

ABSTRACTHorashim East is a newly discovered Middle Palaeolithic open‐air occurrence in central Israel, revealed during a thematic prehistoric survey. Hundreds of lithic items were found, including an early‐stage biface, Levallois cores and products. As only a few open‐air settlements are known from the Middle Palaeolithic Levant, the discovery of Horashim East sheds new light on human land‐use patterns during this period and reinforces the notion that central‐eastern Israel was favourable for human settlement throughout the Palaeolithic.
The past in dust: current trends and future directions in Pleistocene geoarcheology of European loess
Authors: Chu Wei , Nett Janina J. 
Published: October 2021

ABSTRACTLoess is a main archive of Pleistocene landscapes and environments and therefore has an important connection to the preservation and interpretation of Paleolithic sites. In Europe, anthropogenic sites have been found in loess because of past local occupation. At one extreme, sites are well preserved with minimal disturbance often accompanied by embedded proxies to estimate ecological parameters. On the other hand, loess deposits have undergone post‐depositional alterations such as weathering, pedogenesis or bioturbation due to changing environmental conditions or other disturbances that obscure anthropogenic sites. We outline the current state of research and connections between Paleolithic archeology and loess research while introducing a series of subsequent regional case studies as part of a special issue. We also make recommendations for future work to incorporate a wider variety of methods to create more robust inferences on hominin and environmental evolution and their connections.
More sentinel lymph node biopsies for thin melanomas after transition to AJCC 8th edition do not increase positivity rate: A Danish population‐based study of 7148 patients
Authors: Weitemeyer Marie B. , Helvind Neel M. , Brinck Anne M. , Hölmich Lisbet R. , Chakera Annette H. 
Published: October 2021

AbstractBackgroundWe evaluated the outcome of sentinel lymph node biopsies (SLNB) in patients with thin melanoma before and after the implementation of AJCC 8th edition (AJCC8) and identified predictors of positive sentinel lymph nodes (+SLN).MethodsPatients diagnosed with T1 melanomas (Breslow thickness ≤1 mm) during 2016–2017 as per AJCC 7th edition (AJCC7) (n = 3414) and 2018–2019 as per AJCC8 (n = 3734) were identified in the Danish Melanoma Database.ResultsMore SLNBs were performed in the AJCC8 cohort compared to the AJCC7 (22.2% vs. 16.2%, p < 0.001), with no significant difference in +SLN rates (4.7% vs. 6.7%, p = 0.118). In the AJCC7 + SLN subgroup, no melanomas were ulcerated, 94.6% had mitotic rate (MR) ≥ 1, 67.6% were ≥0.8 mm and 32.4% would be T1a according to AJCC8. In the AJCC8 + SLN subgroup, 10.3% were ulcerated, 74.4% had MR≥ 1, 97.4% were ≥0.8 mm and 23.1% would be T1a according to AJCC7. On multivariable analysis younger age and MR ≥ 1 were significant predictors of +SLN.ConclusionMore SLNBs were performed in T1 melanomas after transition to AJCC8 without an increase in +SLN rate. None of the AJCC8 T1b criteria were significant predictors of +SLN. We suggest that mitosis and younger age should be considered as indications for SLNB in thin melanoma.
Diverse but uncertain responses of picophytoplankton lineages to future climate change
Authors: Flombaum Pedro , Martiny Adam C. 
Published: October 2021

AbstractClimate change is projected to modify the physical and chemical environment of the ocean, but the quantitative impact on the distribution of phytoplankton groups is unclear. Most Earth System Models (ESMs) predict future declines of phytoplankton in low latitude waters, contradicting observations showing that picophytoplankton can reach high abundance in warm waters. Here, we used a historic and three climate scenarios along with quantitative niche models to project Prochlorococcus, Synechococcus, and picoeukaryotic phytoplankton distributions for the year 2100. First, we found global responses with up to 50% and 9% increase for Prochlorococcus and Synechococcus abundances, respectively, and 8% decrease for picoeukaryotic phytoplankton. All groups increased in abundance at low latitude, and Synechococcus and picoeukaryotic phytoplankton showed bands of decreases and increases in mid‐ and high‐latitudes, respectively. Prochlorococcus temporal trends were consistent among ESMs and increased with the strength of the scenario, while Synechococcus and picoeukaryotic phytoplankton showed mixed results. Second, we evaluated sources of uncertainty associated to future projections. The anthropogenic uncertainty, associated to climate scenarios, increased with time and was relevant for Prochlorococcus. The environmental and biological uncertainty, associated to ESMs and niche models, respectively, represented the largest fraction but differed among lineages. Quantifying uncertainties is key because the predicted differences in the future distribution and abundance can have large‐scale consequences on ocean ecosystem functioning.
Light‐activated photosealing with human amniotic membrane strengthens bowel anastomosis in a hypotensive, trauma‐relevant swine model
Authors: Scott Benjamin B. , Wang Ying , Wu Ruby C. , Randolph Mark A. , Redmond Robert W. 
Published: October 2021

AbstractBackgroundGastrointestinal anastomotic leakage is a dreaded complication despite advancements in surgical technique. Photochemical tissue bonding (PTB) is a method of sealing tissue surfaces utilizing photoactive dye. We evaluated if crosslinked human amniotic membrane (xHAM) photosealed over the enteroenterostomy would augment anastomotic strength in a trauma‐relevant swine hemorrhagic shock model.MethodsYorkshire swine (40–45 kg, n = 14) underwent midline laparotomy and sharp transection of the small intestine 120 cm proximal to the ileocecal fold. Immediately following intestinal transection, a controlled arterial bleed was performed to reach hemorrhagic shock. Intestinal repair was performed after 60 minutes and autotransfusion of the withdrawn blood was performed for resuscitation. Animals were randomized to small intestinal anastomosis by one of the following methods (seven per group): suture repair (SR), or SR with PTB augmentation. Animals were euthanized at postoperative Day 28 and burst pressure (BP) strength testing was performed on all excised specimens.ResultsMean BP for SR, PTB, and native tissue groups were 229 ± 40, 282 ± 21, and 282 ± 47 mmHg, respectively, with the SR group statistically significantly different on analysis of variance (p = 0.02). Post‐hoc Tukey all‐pairs comparison demonstrated a statistically significant difference in burst pressure strength between the SR only and the PTB group (p = 0.04). All specimens in SR group ruptured at the anastomosis upon burst pressure testing, while all specimens in the PTB group ruptured at least 2.5 cm from the anastomosis.ConclusionPhotosealing with xHAM significantly augments the strength of small intestinal anastomosis performed in a trauma porcine model.
Study of Adsorption Uptake via Spillover Mechanism for CNT/Cobalt Composites
Authors: Dixit Shalini , Patodia Tarun , Verma Reena , Lavania Anju , Malhotra Anu , Sharma K.B. , Jain Ankur , Tripathi Balram 
Published: October 2021

AbstractCNT/Co composites are successfully synthesized through ultra‐sonication method. Adsorption uptake up to 1.8wt% for CNT5%Co95% composite is observed at 60 psi pressure by Sieverts type spectrometer. The enhancement of adsorption in the CNT‐Co composite is attributed to hydrogen spillover effect. The defective structure of the CNTs after sonication may be the factor to promote hydrogen spillover.
The multiple‐criteria decision analysis of the financial and business models for the construction of new nuclear unit in the Czech Republic
Authors: Stašáková Tereza , Vlček Tomáš 
Published: October 2021

AbstractWhen discussing their future energy mix, many countries are reconsidering the position of the nuclear energy. One of the main arguments against new nuclear plants is the extremely high investment cost. Nevertheless, some countries still perceive nuclear energy as a strategic sector and are willing to invest in it, using different financial strategies. The Czech Republic has initiated the decision‐making process for building and financing a new nuclear unit. This article introduces readers to the general issues of nuclear financing in a liberalised European market and, using multiple‐criteria decision analysis, identifies the most suitable model for financing the construction of the new unit in the Czech Republic. The three models under consideration are introduced using the examples of three European nuclear power plant projects: Hinkley Point C, Hanhikivi and Paks II. The article compares the three new nuclear power plant projects, each representing a various financial model, with the 2015 National Action Plan for the Development of the Nuclear Energy Sector in the Czech Republic and evaluates them to choose the best model for the new nuclear power plant in the Czech Republic. Thus, it provides a comprehensive overview of the link between theoretical models, their application, and the transferability of the models.
Chaotic state of matter search with elite opposition based learning: A new hybrid metaheuristic algorithm
Authors: Khanduja Neha , Bhushan Bharat 
Published: October 2021

AbstractIn this article, the exploration and stochastic property of elite opposition‐based learning and chaotic maps are utilized to introduce a hybridized metaheuristic optimization technique. Both the techniques are combined with state of matter search optimization to enhance its capability of locating global minima. The proposed hybrid algorithm is tested on various benchmark functions and compared with the state of mater search optimization to verify its efficiency. The results show that the proposed hybrid algorithm gives better convergence for various benchmark functions.
Preparation and mechanical properties of water‐dispersible hyperbranched polymer grafted carbon black/natural rubber composites by latex blending method
Authors: Han Fei , Zhang Zhiliang , Ma Teng , Shou Chongqi 
Published: October 2021

AbstractIn order to improve the mechanical properties of rubber‐matrix composites, carboxyl‐terminated hyperbranched poly (2‐hydroxypropane‐1,2,3‐tricarboxylic acid) grafted carbon black (CB‐g‐CTHBP) was prepared, and it could be stably dispersed in water for up to 90 days. CB‐g‐CTHBP dispersion and natural rubber latex were blended to obtain NR/CB‐g‐CTHBP, and the effect of CB‐g‐CTHBP content on the mechanical properties of composites was discussed. The results show that the dispersibility and wettability of CB‐g‐CTHBP to composites are significantly improved after grafting hyperbranched polymer onto the surface. Compared with the composite filled with NR/CB, when the amount of filler is 30 phr, tensile strength, tear strength, and shore A hardness of NR/CB‐g‐CTHBP increase by 54.78%, 55.13%, and 20.96%, respectively. Moreover, CB‐g‐CTHBP could disperse more evenly in the natural rubber‐matrix, and the interaction between CB‐g‐CTHBP and rubber‐matrix could further enhance in the composite.
Successful perioperative management using prothrombin complex concentrates in patients with severe congenital protein C deficiency
Authors: Inoue Kyohei , Arakawa Yuki , Noguchi Jun , Irikura Tomoya , Watakabe Mai , Hiraki Takamasa , Honda Mamoru , Mitani Yuichi , Mori Makiko , Fukuoka Kohei , Oshima Koichi , Kawashima Hiroshi , Kurihara Jun , Koh Katsuyoshi 
Published: October 2021

AbstractPerioperative management of severe congenital protein C deficiency remains unestablished. This deficiency is often treated with anticoagulants, such as warfarin. Although anticoagulants need to be perioperatively discontinued, there are few methods for the management of such patients. We adopted a method for administering prothrombin complex concentrates (PCC), which includes intermittent administration of inactive protein C (PPSB‐HT), and examined its outcome as a perioperative management approach for severe congenital protein C deficiency. Three patients underwent our perioperative management six times. We monitored activity levels of protein C, factor IX, and so forth. These patients could be perioperatively managed with PCC treatment.