bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogenic Amines (BAs) in Meat Products, Regulatory Policies, and Detection Methods
Authors: Shashank Abhinay , Gupta Arun Kumar , Singh Shubhendra , Ranjan Rajeev 
Published: February 2021

Background:
Biogenic amines (BAs) can be defined as low molecular weight organic
nitrogen compounds formed by amino acid decarboxylation or by amination and transamination of
aldehydes and ketones. Histamine, tryptamine, tyramine, putrescine, phenylethylamine, and cadaverines
are some of the BAs reported in fermented foods which are synthesized by decarboxylation
of histidine, tryptophan, tyrosine, ornithine, phenylalanine, and lysine, respectively. In meat
and meat products, they are associated with spoilage. Excessive oral intake of these compounds
can result in several toxic effects on human health such as hypertension, cardiac palpitations,
headache, nausea, diarrhea, and flushing.

Objective:
Therefore, BAs must be controlled within the safety level to ensure the safety of fermented
meat products. The ratio and quantity of biogenic amines present can be used as an indicator
of the hygienic state of raw material as well as manufacturing practices.

Conclusion:
The detection and quantification of biogenic amines are commonly performed by
chromatographic approaches such as gas chromatography (GC), high-performance liquid chromatography
(HPLC), and capillary electrophoresis (CE). It can also be done by non-chromatographic
approaches like optical biosensors, disposable screen-printed electrode biosensors with enzymes,
transmission electron microscopy (TEM), and FTIR. There is enormous scope for making these
analytical techniques more rapid and simple. Thus, the purpose of this review is to deliver concise
information about the BAs, their significance, regulatory aspects, and the methods available to
quantify the BAs in meat and meat products.
Serratia, No Longer an Uncommon Opportunistic Pathogen – Case Series & Review of Literature
Authors: Gupta Varsha , Sharma Shiwani , Pal Kritika , Goyal Poonam , Agarwal Deepak , Chander Jagdish 
Published: February 2021

Background:
Serratia spp. is a common enteric bacterium generally thought not to be
pathogenic in the gastrointestinal tract. Serratia marcescens is a member of the genus Serratia, which
is a part of the family Enterobacteriales. Of all Serratia species, S. marcescens is the most common
clinical isolate and the most important human pathogen.

Objective:
We discuss here four cases of Serratia marcescens which were reported in our laboratory at
the Department of Microbiology Government Medical College and Hospital Chandigarh within six
months of duration.

Method:
All the samples were processed and identified using standard microbiological techniques. The
isolates of Serratia marcescens were identified, depending upon their biochemical and morphological
characteristics, and further confirmed by MALDI-TOF-MS, PGIMER Chandigarh.

Result:
In one of the four cases, polymicrobial infection was observed, and among the cases, one patient
was diabetic and the rest three patients were immunocompetent. The importance of detection of
Serratia marcescens is related to the concern regarding its increased spread in hospital settings as
nosocomial infection.

Conclusion:
We need to identify and isolate this pathogen not thinking of it only as a contaminant and
opportunistic pathogen but as a pathogen which can lead to serious infections in hospital settings.
QSAR Analysis of Quinazolinyl-arylurea Derivatives as Potential Anti- Cancer Agents: GA-MLR Chemometric Approach
Authors: Srinivas Medidi , Neharika K Grace 
Published: February 2021

Background:
Cancer is the most common malignancy in men and women globally. The
tyrosine kinases and serine/threonine kinases are essential to cell mediators for extra & intracellular
signal transduction processes and play a key role in cell proliferation, differentiation,
migration, metabolism, and programmed cell deaths. In this context, kinases are considered as a
potential drug target for cancer therapy.

Methods:
In the present study, a two-dimensional (2D) quantitative structure-activity relationship
(2D-QSAR) was performed to analyze anticancer activities of 28 quinazolinyl-arylurea (QZA)
derivatives based on the liver (BEL-7402), stomach (MGC-803), and colon (HCC-827) cancer cell
lines using multiple linear regression (MLR) analysis. It was accomplished using 2D-QSAR
analysis on the available IC50 data of 28 molecules based on theoretical molecular descriptors to
develop predictive models that correlate structural features of QZA derivatives to their anticancer
activities. A suitable set of molecular descriptors, such as constitutional, topological, geometrical,
electrostatic, and quantum-chemical descriptors were calculated to represent the structural features
of compounds. The genetic algorithm (GA) method was used to identify the important molecular
descriptors to build the QSAR models and used to predict the anti-cancer activities.

Results and Discussion:
The obtained 2D-QSAR models were vigorously validated using various
statistical metrics using leave-one-out (LOO) and external test set prediction approaches. The best
predictive models by MLR gave highly significant square of correlation coefficient (R2
train) values
of 0.799, 0.815, and 0.779 for the training set, and the correlation coefficients (R2
test) were obtained
0.885, 0.929, and 0.774 for the test set for the liver, stomach, and colon cancer cell lines. The
models also demonstrated good predictive power confirmed by the high value of cross-validated
correlation coefficient Q2 value of 0.663, 0.717, and 0.671 for three different cancer cell lines.
Importantly, the model's quality was judged as well based on mean absolute error (MAE) criteria,
and the results were consistent with proposed limits by Golbraikh and Tropsha.

Conclusion:
The QSAR results of the study indicated that the proposed models were robust and
free from chance correlation. This study indicated that maxHBint7, SpMax8_Bhm, and
ETA_Beta_ns_d have positively contributed descriptors for anti-cancer activity in the liver,
stomach, and colon cancer cell lines and a detailed mechanistic interpretation of each model
revealed important structural features that were responsible for favorable or unfavorable for anticancer
activity. The predictive ability of the proposed models was good and may be useful for
developing more potent quinazolinyl-arylurea compounds as anti-cancer agents.
Functionalized Photocatalytic Nanocoatings for Inactivating COVID-19 Virus Residing on Surfaces of Public and Healthcare Facilities
Authors: Channegowda Manjunatha 
Published: February 2021

:
The current COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) has affected the large population across the globe by serious respiratory
illness and death. Since the medicine for this new disease is yet to discover, the treatment options
against pandemic COVID-19 are very limited and unsatisfactory. Further, the hospitals,
wherethe COVID-19 patients are admitted for treatment, are the major source of the spread of this
virus, as it survives on the surfaces of inanimate objects for days. Therefore, hospitals have become
hotspots for SARS-CoV-2 infection. The non-availability of quality personal protective equipment
(PPE) and exposure to severe COVID patients have been major factors for the infection in millions
of healthcare workers. However, developing an effective medicine has remained challenging due to
its unpredictable mutation rate. Here, this article describes functionalized photocatalytic nanocoatings
to destroy the COVID-19 virus, which can be applied on the surface of inanimate objects,
such as paper, cloth, glass, wood, ceramic, metallic, and polymeric surfaces. With the supporting
experimental results, various possible ways of killing the virus and its relevant mechanism are discussed.
This article provides new insights for developing nano solutions to address this COVID-19
issue.
Production of Compact Powder Blush on from Secang Wood (Caesalpinia sappan L.) Extract
Authors: Setyawaty Rety , Dwiyanti Mela , Dewanto Dewanto 
Published: February 2021

Secang wood (Caesalpinia sappan L.) is one of the local resources that contain natural pigments, namely brazilin. Brazilin is a pigment derived from Secang wood (Caesalpinia sappan L.) that is potentially used as a natural dye. This study aims to prove that Secang Wood (Caesalpinia sappan L.) can be applied as a dye in Compact Powder Blush On.The method for obtaining Secang wood (Caesalpinia sappan L.) extract uses the maceration extraction method with a sample of Secang wood (Caesalpinia sappan L.) of 250 gram and ethanol 96% then evaporated in a water bath with a temperature below 80 0C resulting in a yield of Secang wood (Caesalpinia sappan L.) extract of 27.87%. pH during the maceration process must be kept neutral, if it is not stable then it is added citric acid or sodium bicarbonate. The components of the Compact Powder Blush On are Talcum, Kaolin, Parrafin Liquid, Okside Zinc, Isopropyl myristate, and the addition of Secang wood extract (Caesalpinia sappan L.) with a concentration of 5%, 10%, 20%. Tests on preparations made include pH test, sticky power test, topical test, and stability test.The observations show that the Compact Powder Blush On preparation at a concentration of 5%, 10%, and 20% Secang wood extract (Caesalpinia sappan L.) is pink, easily applied, has an average adhesion of 13.83%, produces a pink color when applying, and has a pH of 7. However, using Secang wood (Caesalpinia sappan L.) as a Blush On dye does not have color stability. Based on the results of the study it can be concluded that Secang Wood (Caesalpinia sappan L.) can be used as a natural dye Compact Powder Blush On, but additional ingredients are needed so that the color remains stable during storage at room temperature.
Pengaruh Variasi Komposisi Pemanis Xilitol dan Aspartam Terhadap Formulasi Tablet Kunyah Ekstrak Daun Pepaya (Carica papaya) The effect
Authors: Ropiqa Meri , Devi Sisca , Nugroho Akhmad Kharis , Murti Yosi Bayu 
Published: February 2021

Pepaya merupakan salah satu tanaman yang dimanfaatkan sebagai antiplasmodium di Indonesia. Kandungan alkaloid karpain pada daun yang bertanggung jawab sebagai senyawa antiplasmodium memiliki rasa pahit sehingga perlu diformulasikan dalam bentuk sediaan tablet yang mudah diterima. Berkaitan dengan prevalensi malaria yang sering menyebabkan kematian pada usia 5 hingga 9 tahun, maka perlu dilakukan formulasi bentuk sediaan tablet kunyah yang merupakan bentuk sediaan yang disukai kategori usia anak. Penelitian ini bertujuan untuk mengetahui pengaruh variasi komposisi pemanis xilitol dan aspartam terhadap karakteristik fisik granul dan fisik tablet kunyah. Formulasi tablet kunyah dibuat dengan kombinasi xilitol dan aspartam sebanyak tiga formula, pada formula I dengan perbandingan xilitol:aspartam (284:40), formula II (292:32), dan formula III ( 300:24). Berdasarkan hasil penelitian pada uji kekerasan tablet menunjukkan ada perbedaan nilai yang signifikan (p < 0,05) antara satu formula dengan formula lainnya, hal ini menunjukan variasi pemanis sangat berpengaruh terhadap kekerasan tablet yang dihasilkan.
Proteinuria and Clinical Outcomes in Hospitalized COVID-19 Patients
Authors: Karras Alexandre , Livrozet Marine , Lazareth Hélène , Benichou Nicolas , Hulot Jean-Sébastien , Fayol Antoine , Chauvet Sophie , Jannot Anne-Sophie , Penet Marie-Aude , Diehl Jean-Luc , Godier Anne , Sanchez Olivier , Mirault Tristan , Thervet Eric , Pallet Nicolas 
Published: February 2021

Background and objectives
Kidney involvement is frequent among patients with coronavirus disease 2019 (COVID-19), and occurrence of AKI is associated with higher mortality in this population. The objective of this study was to describe occurrence and significance of proteinuria in this setting.

Design, setting, participants & measurements
We conducted a single-center retrospective study to describe the characteristic features of proteinuria measured within 48 hours following admission among patients with COVID-19 admitted in a tertiary care hospital in France, and to evaluate its association with initiation of dialysis, intensive care unit admission, and death.

Results
Among 200 patients with available data, urine protein-creatinine ratio at admission was ≥1 g/g for 84 (42%), although kidney function was normal in most patients, with a median serum creatinine of 0.94 mg/dl (interquartile range, 0.75–1.21). Median urine albumin-creatinine ratio was 110 mg/g (interquartile range, 50–410), with a urine albumin-protein ratio <50% in 92% of patients. Urine retinol binding protein concentrations, available for 85 patients, were ≥0.03 mg/mmol in 62% of patients. Urine protein-creatinine ratio ≥1 g/g was associated with initiation of dialysis (odds ratio, 4.87; 95% confidence interval, 2.03 to 13.0; P<0.001), admission to the intensive care unit (odds ratio, 3.55; 95% confidence interval, 1.93 to 6.71; P<0.001), and death (odds ratio, 3.56; 95% confidence interval, 1.90 to 6.54; P<0.001).

Conclusions
Proteinuria is very frequent among patients admitted for COVID-19 and may precede AKI. Low levels of albuminuria suggest a predominant tubular origin, confirmed by the elevated levels of urine retinol binding protein. Urine protein-creatinine ratio ≥1 g/g at admission is strongly associated with poor kidney and patient outcome.
Peranan industri sub sektor perhotelan terhadap penyerapan tenaga kerja di Provinsi Jambi
Authors: Lestari Christina Maya , Zulfanetti Zulfanetti , Artis Dearmi 
Published: February 2021

This study aims to determine the effect of Number of Hotels, Number of Rooms, Room Occupancy Rates, Minimum Wages on employment opportunities in Hotels in Jambi Province. This study uses an Ordinary Least Squares (OLS) multiple regression analysis model.Based on the results of the regression analysis, it is known that the variable number of hotels and minimum wages has a significant effect on the level of employment in Jambi Province, while the variable number of rooms and occupancy rates have no significant effect on the employment of industrial labor in the hotel sub-sector in Jambi Province.
Keywords: Number of Hotels, Number of Rooms, Occupancy Rate, Minimum Wage, Absorption of Labor.
Pengaruh pertumbuhan ekonomi, upah minimum dan jumlah tenaga kerja terhadap kemiskinan di Kota Jambi Tahun 2000 – 2017
Authors: Rozi Fahrur , Yulmardi Yulmardi , Umiyati Etik 
Published: February 2021

This study aims to: 1) Know and analyze the development of economic growth, minimum wages, number of workers and poverty levels in Jambi City; and 2) To find out and analyze the influence of economic growth, minimum wages and the number of workers and poverty levels in Jambi City. The analytical tool used in this study is multiple linear regression.The results of this study are that economic growth in Jambi City experienced fluctuations during 2000-2017. The minimum wage in the city of Jambi has increased annually during 2000-2017. Labor in Jambi City experienced fluctuations during 2000-2017. The poverty rate in Jambi City experienced annual fluctuations during 2000-2017. From the results of the processed multiple linear regression that the variable economic growth, minimum wage, labor simultaneously have a significant effect on the level of poverty, it can be seen from the significant value of 0.002 which is smaller than 0.05. While partially the independent variables that influence the poverty level are minimum wages and labor, it can be seen from the significant values ​​smaller than 0.05.
Keywords: Economic Growth, Minimum Wage, Number of Labor, and Poverty Levels.
Analisis pengaruh pertumbuhan ekonomi, investasi, belanja daerah, inflasi dan upah terhadap kesempatan kerja di Provinsi Jambi
Authors: Desideria Deyana , Prihanto Purwaka Hari , Hardiani Hardiani 
Published: February 2021

The purpose of this research were to analyze the economic growth, investation, government expenditure, inflation, and wage the employment of Jambi Province. This research used ordinary least squares. The F test indicated that simultaneously the variables of the economic growth, investation, government expenditure, inflation, and wage significantly affected the employment of Jambi Province. While T test revealed that partially investation, government expenditure, and wage affected the employment of Jambi Province. Meanwhile, the variables of economic growth and inflation insignificant to the employment of Jambi Province.
Keywords: Employmen Oppotunity, Investation, Government Expendicture, Wage.
Determinan konsumsi rumah tangga miskin di Kecamatan Dendang Kabupaten Tanjung Jabung Timur
Authors: Ningsih Kartika Wahyu , Syaparuddin Syaparuddin , Rahmadi Selamet 
Published: February 2021

The purpose of this study was to determine the socioeconomic characteristics of poor households and the influence of household income, number of family members, household head education, social assistance status, and type of work of the head of the household on consumption of poor households in Dendang District. The data used are primary data obtained from questionnaires and direct interviews with a sample of 93. The sampling method used was random sampling. The data an alysis tools are used is descriptive and quantitative analysis’s with multiple linear analysis. The simultaneous results of multiple linear regression analysis that consumption of poor households in Dendang District are influenced by household head income, number of family members of the head of household, education of the head of the household, type of work of the head of the household and status of social assistance. While partially the household income variable and the number of family dependents have a significant effect on the consumption of poor households in Dendang Subdistrict, while the education of the head of the household, the type of work of the head of household and the status of social assistance do not have a significant effect on poor households in Dendang District.
Keywords: Poor household consumption, household income, number of family members, education, social assistance status, and type of work.
Pengaruh pertumbuhan ekonomi, tingkat kemiskinan, pengeluaran pemerintah, tingkat pengangguran terbuka terhadap Indeks Pembangunan Manusia (IPM) Provinsi-provinsi di Sumatera
Authors: ZA Dzaki Furqoni , Junaidi Junaidi , Bhakti Adi 
Published: February 2021

Study are as follows: To analyze the effect of economic growth, poverty level, government expenditure and open unemployment on the Human Development Index (HDI) of the Provincial Provinces in Sumatra for the period 2013-2017. Based on the results of the study that economic growth has a significant effect on the human development index. Poverty level has a significant effect on the human development index. Open unemployment has a significant effect on the human development index. Government expenditure has a significant effect on the Human Development Index.
Keywords: Economic Growth, Poverty Level, Government Expenditures, Open Unemployment Rate, and Human Development Index.
Analisis produksi dan pendapatan petani kelapa dalam di Kecamatan Pengabuan Kabupaten Tanjung Jabung Barat
Authors: Amin Khoirul , Zulgani Zulgani , Prihanto Purwaka Hari 
Published: February 2021

The purpose of this research is to find out and analyze the socio-economic characteristics of coconut farmers in Pengabuan Subdistrict and to analyze factors affecting the production and income of coconut farmers in Pengabuan Subdistrict in West Tanjung Jabung Regency.The method used this research is quantitative descriptive methode. The data used in this study is primary data. The analytical tool used is multiple linear regression. The results showed that at a significance level of 10% only land area variable had a significant effect on coconut production in Pengabuan Sub-District, Tanjung Jabung Barat District while labor, fertilizer and pest variables did not significantly influence the coconut production in Sub-District Pengabuan Tanjung Regency Jabung Barat. However, simultaneously the dependent variable significant influences of the production coconut in Pengabuan District, Tanjung Jabung Barat District. In terms of income, production, selling price, and management costs significantly influence the income of coconut farmers in Pengabuan District, both partially and simultaneousl in 10% significant level.
Analisis penerimaan retribusi dan strategi pengembangan objek wisata Taman Anggrek Sri Soedewi Provinsi Jambi
Authors: Aghniyah Aghniyah , Syaparuddin Syaparuddin , Achmad Erni 
Published: February 2021

study aims to analyze retribution income of Taman Anggrek Sri Soedewi object and expected to produce a possible strategy that can be applied to increase the amount of retribution income in the tourism department of Anggrek Sri Soedewi Garden object in Jambi Province. In this research, used are is primary and secondary of data. This study usds data from the financial statements of tourism within 4 years from 2014 to 2018. The data were collected by questionnaire, observation, interview conducted to 21 respondents comprising of head division, and managements of tourism object, as well as visitors was selected by accidental sampling method. In SWOT matrix analysis, results obtained six alternative strategies, namely : (1) enhancement cooperation, (2) improving development program, (3) improving facilities and infrastructure, (4) allocation of human resources, (5) increasing a flower collection, and (6) increased promotion.
Analisis pengaruh modal usaha, umur, pendidikan dan jam kerja terhadap pendapatan pedagang pasar tradisional di Desa Sungai Saren Kecamatan Bram Itam Kabupaten Tanjung Jabung Barat
Authors: Rianto Selamat , Zulgani Zulgani , Prihanto Purwaka Hari 
Published: February 2021

This study aims to analyze the effect of capital, age, education and working hours on the income of traditional market traders in Sungai Saren Village, Bram Itam District, Tanjung Jabung Barat Regency. The data used in this study are primary data, the sampling method used in this study is Purposive Sampling with 56 respondents as traders, the analytical tool used is Multiple Linear Analysis.Based on the results of the study obtained a probability value of 0,000 for the F Test and partial test of Capital, Age, Education and Working Hours variables. This shows that the variables simultaneously and partially all the variables have a significant effect on the income of Traders in the Traditional Market of Sungai Saren, Bram Itam District, Tanjung Jabung Barat Regency. Determination Coefficient Value (R2) of 0.520 shows that the influence of Capital, Age, Education and Working Hours, Work on the income of Traders of Sungai Saren Market, Bram Itam District, Tanjung Jabung Barat Regency is 52%.