bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances and Perspectives on Powder‐Based Halide Perovskite Film Processing
Authors: Leupold Nico , Panzer Fabian 
Published: January 2021

AbstractHalide perovskites have undergone an impressive development and could be used in a wide range of optoelectronic devices, where some of them are already at the edge of commercialization, e.g., perovskite solar cells. Recently, interest in perovskites in powder form has increased, as for example, they are found to exhibit high stability and allow for easy production of large quantities. Accordingly, also the topic of processing thin and thick films on the basis of perovskite powders is currently gaining momentum. Here, perovskite powder can form the basis for both, typical wet and solvent‐based processing approaches, as well as for dry processes. In this Progress Report, the recent developments of halide perovskites in powder form and of film processing approaches are summarized that are based on them. The advantages and opportunities of the different processing methods are highlighted, but their individual drawbacks and limitations are also discussed. Prospects are also pointed out and possible steps necessary to unlock the full potential of powder‐based processing methods for producing high quality thick and thin perovskite layers in the future are discussed.
Harvesting Air and Light Energy via “All‐in‐One” Polymer Cathodes for High‐Capacity, Self‐Chargeable, and Multimode‐Switching Zinc Batteries
Authors: Xie Xiuli , Fang Zhengsong , Yang Meijia , Zhu Fangming , Yu Dingshan 
Published: January 2021

AbstractAqueous rechargeable Zinc (Zn)–polymer batteries are promising alternatives to prevalent Li‐ion cells in terms of cost, safety, and rate capability but they suffer from limited specific capacity in addition to poor environmental adaptability. Herein, air and light are successfully utilized from external environments in single near‐neutral two‐electrode Zn batteries to enable remarkably improved electrochemical performance, fast self‐charging, and switchable multimode‐operation from Zn–polymer to Zn–air cells. This system is enabled by a well‐designed polyaniline‐nanorod‐array based “all‐in‐one” cathode combining reversible redox capability, oxygen reduction activity, and photothermal‐responsiveness. The initiative design allows perfect integration of multiple energy harvesting from ambient “air” and light, energy conversion, and storage in one single cathode. Thus, it can act as an efficient light‐assisted electrically‐rechargeable Zn–polymer cell featuring the highest specific capacity of 430.0 mAh g−1 among all existing polymer cathodes. Without external power sources, it can be self‐charged to deliver a high discharging capacity of 363.1 mAh g−1 by concurrently harvesting chemical energy from air and light energy for only 20 min. It can also switch to a light‐responsive Zn–air battery mode to surmount the output capacity limit of Zn–polymer battery mode for continued electricity supply.
Metal–Ligand Based Mechanophores Enhance Both Mechanical Robustness and Electronic Performance of Polymer Semiconductors
Authors: Wu Hung‐Chin , Lissel Franziska , Wang Ging‐Ji Nathan , Koshy David M. , Nikzad Shayla , Yan Hongping , Xu Jie , Luo Shaochuan , Matsuhisa Naoji , Cheng Yuan , Wang Fan , Ji Baohua , Li Dechang , Chen Wen‐Chang , Xue Gi , Bao Zhenan 
Published: January 2021

AbstractThe backbone of diketopyrrolopyrrole‐thiophene‐vinylene‐thiophene‐based polymer semiconductors (PSCs) is modified with pyridine (Py) or bipyridine ligands to complex Fe(II) metal centers, allowing the metal–ligand complexes to act as mechanophores and dynamically crosslink the polymer chains. Mono‐ and bi‐dentate ligands are observed to exhibit different degrees of bond strengths, which subsequently affect the mechanical properties of these Wolf‐type‐II metallopolymers. The counter ion also plays a crucial role, as it is observed that Py‐Fe mechanophores with non‐coordinating BPh4– counter ions (Py‐FeB) exhibit better thin film ductility with lower elastic modulus, as compared to the coordinating chloro ligands (Py‐FeC). Interestingly, besides mechanical robustness, the electrical charge carrier mobility can also be enhanced concurrently when incorporating Py‐FeB mechanophores in PSCs. This is a unique observation among stretchable PSCs, especially that most reports to date describe a decreased mobility when the stretchability is improved. Next, it is determined that improvements to both mobility and stretchability are correlated to the solid‐state molecular ordering and dynamics of coordination bonds under strain, as elucidated via techniques of grazing‐incidence X‐ray diffraction and X‐ray absorption spectroscopy techniques, respectively. This study provides a viable approach to enhance both the mechanical and the electronic performance of polymer‐based soft devices.
Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance
Authors: Xue Yiyuan , Zhu Zhou , Zhang Xin , Chen Junyu , Yang Xiao , Gao Xiaomeng , Zhang Shu , Luo Feng , Wang Jian , Zhao Weifeng , Huang Chao , Pei Xibo , Wan Qianbing 
Published: January 2021

AbstractOwing to the insufficient guidance of new bone formation in orthopedic and craniomaxillofacial surgery, construction of a guided bone regeneration membrane to support vascularized bone regeneration remains a challenge. Herein, an electrospun asymmetric double‐layer polycaprolactone/collagen (PCL/Col) membrane modified by metal–organic framework (MOF) crystals is developed. The optimization of the PCL/Col weight ratio (1:1 and 1:1.5) enables the composite membrane with a balanced tensile strength (only fell by 49.9% in wet conditions) and a controlled degradation rate (completely degraded at 12 weeks). The MOF crystals can provide a pH‐responsive release of Zn2+ ions. In vitro experiments indicate that the barrier layer functions to prevent the infiltration of fibrous connective tissue. The MOF crystal layer functions to enhance osteogenesis and angiogenesis in vitro. Using a rat calvarial defect model, the MOF crystals exhibit a sign of osteoinductivity along with blood vessel formation after 8 weeks post‐surgery. Strikingly, when assessed in a chick chorioallantoic membrane model, the MOF modified membrane demonstrates a significant angiogenic response, which can be envisaged as its outstanding merits over the commercially Col membrane. Therefore, the MOF crystals represent an exciting biomaterial option, with neovascularization capacity for bone tissue engineering and regenerative medicine.
Blood‐Compatible Materials: Vascular Endothelium‐Mimetic Surfaces that Mitigate Multiple Cell‐Material Interactions
Authors: Vlcek Jessica R. , Hedayati Mohammadhasan , Melvin Alyssa C. , Reynolds Melissa M. , Kipper Matt J. 
Published: January 2021

AbstractWhen flowing whole blood contacts medical device surfaces, the most common blood–material interactions result in coagulation, inflammation, and infection. Many new blood‐contacting biomaterials have been proposed based on strategies that address just one of these common modes of failure. This study proposes to mitigate unfavorable biological reactions that occur with blood‐contacting medical devices by designing multifunctional surfaces, with features optimized to meet multiple performance criteria. These multifunctional surfaces incorporate the release of the small molecule hormone nitric oxide (NO) with surface chemistry and nanotopography that mimic features of the vascular endothelial glycocalyx. These multifunctional surfaces have features that interact with coagulation components, inflammatory cells, and bacterial cells. While a single surface feature alone may not be sufficient to achieve multiple functions, the release of NO from the surfaces along with their modification to mimic the endothelial glycocalyx synergistically improves platelet‐, leukocyte‐, and bacteria‐surface interactions. This work demonstrates that new blood‐compatible materials should be designed with multiple features, to better address the multiple modes of failure of blood‐contacting medical devices.
Out‐of‐the‐Box Nanocapsules Packed with On‐Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy
Authors: Zhao Di , Jiang Kai , Wang Yuqi , Cheng Jin , Mo Fangli , Luo Tao , Guo Yuanyuan , Zhang Chuan , Song Jie 
Published: January 2021

AbstractMost anticancer drugs, particularly paclitaxel (PTX), are suffering the challenges of cancer chemotherapy due to their poor water‐solubility, high toxicity under effective therapeutic dosages, and multi‐drug resistance. Currently, nanoscale drug delivery systems (DDSs) represent an efficient platform to overcome the above challenges. However, those DDSs generally need a careful design of conjugation, complexation, or co‐self‐assembly. Herein, a facile out‐of‐the‐box nanocapsule is developed not only to be easily packed with on‐demand hydrophobic anticancer drugs (up to 76% of loading efficiency for PTX), but also to be loaded with other concomitant drugs for synergy therapy (Itraconazole (ITA) here as P‐glycoprotein inhibitor for drug resistance and antiangiogenic agent for combination therapy with PTX). Three kinds of biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) derivatives usually as cross‐linking agents are selected and successfully constructed adequate nanocapsules with single monomer as shell materials. More importantly, as‐prepared nanocapsules have abilities of esterase triggering and lung targeting. Both in vitro and in vivo studies showed that the drug‐loaded nanocapsules can effectively inhibit tumor growth and vascular proliferation in PTX‐resistant tumor models without apparent systemic toxicity. The above results demonstrate that the nanocapsule system provides an effective and universal strategy for lung targeting, esterase triggering, and synergy therapy.
Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing
Authors: Ding Luo‐Gang , Wang Song , Yao Bing‐Jian , Li Fei , Li Yan‐An , Zhao Guo‐Yan , Dong Yu‐Bin 
Published: January 2021

AbstractChronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen (1O2) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine.
Multi‐functional Nanodrug Based on a Three‐dimensional Framework for Targeted Photo‐chemo Synergetic Cancer Therapy
Authors: Xing Enyun , Du Yingying , Yin Juanjuan , Chen Minghui , Zhu Mengyao , Wen Xiaona , Xu Jialiang , Feng Yaqing , Meng Shuxian 
Published: January 2021

AbstractTargeted synergistic therapy has broad prospects in tumor treatments. Here, a multi‐functional nanodrug GDYO‐CDDP/DOX@DSPE‐PEG‐MTX (GCDM) based on three traditional anticancer drugs (doxorubicin (DOX), cisplatin (CDDP) and methotrexate (MTX)) modified graphdiyne oxide (GDYO) is described, for diagnosis and targeted cancer photo‐chemo synergetic therapy. In this system, for the first time, these three traditional anti‐cancer drugs have played new roles and can reduce multidrug resistance through synergistic anti‐tumor effects. Cisplatin can be hybridized with GDYO to form a multifunctional and well‐dispersed three‐dimensional framework, which can not only be used as nano‐drug carriers to achieve high drug loading rates (40.3%), but also exhibit excellent photothermal conversion efficiency (47%) and good photodynamic effects under NIR irradiation. Doxorubicin (DOX) is loaded onto GDYO‐CDDP through π‐π stacking, which is used as an anticancer drug and as a fluorescent probe for nanodrug detection. Methotrexate (MTX) can be applied in tumor targeting and play a role in synergistic chemotherapy with DOX and CDDP. The synthesized multi‐functional nanodrug GCDM has good biocompatibility, active targeting, long‐term retention, sustained drug release, excellent fluorescence imaging capabilities, and remarkable photo‐chemo synergistic therapeutic effects.
Delivery of Anti‐microRNA‐712 to Inflamed Endothelial Cells Using Poly(β‐amino ester) Nanoparticles Conjugated with VCAM‐1 Targeting Peptide
Authors: Dosta Pere , Tamargo Ian , Ramos Victor , Kumar Sandeep , Kang Dong Won , Borrós Salvador , Jo Hanjoong 
Published: January 2021

AbstractEndothelial cells (ECs) are an important target for therapy in a wide range of diseases, most notably atherosclerosis. Developing efficient nanoparticle (NP) systems that deliver RNA interference (RNAi) drugs specifically to dysfunctional ECs in vivo to modulate their gene expression remains a challenge. To date, several lipid‐based NPs are developed and shown to deliver RNAi to ECs, but few of them are optimized to specifically target dysfunctional endothelium. Here, a novel, targeted poly(β‐amino ester) (pBAE) NP is demonstrated. This pBAE NP is conjugated with VHPK peptides that target vascular cell adhesion molecule 1 protein, overexpressed on inflamed EC membranes. To test this approach, the novel NPs are used to deliver anti‐microRNA‐712 (anti‐miR‐712) specifically to inflamed ECs both in vitro and in vivo, reducing the high expression of pro‐atherogenic miR‐712. A single administration of anti‐miR‐712 using the VHPK‐conjugated‐pBAE NPs in mice significantly reduce miR‐712 expression, while preventing the loss of its target gene, tissue inhibitor of metalloproteinase 3 (TIMP3) in inflamed endothelium. miR‐712 and TIMP3 expression are unchanged in non‐inflamed endothelium. This novel, targeted‐delivery platform may be used to deliver RNA therapeutics specifically to dysfunctional endothelium for the treatment of vascular disease.
Review on Li Deposition in Working Batteries: From Nucleation to Early Growth
Authors: Chen Xiao‐Ru , Zhao Bo‐Chen , Yan Chong , Zhang Qiang 
Published: January 2021

AbstractLithium (Li) metal is one of the most promising alternative anode materials of next‐generation high‐energy‐density batteries demanded for advanced energy storage in the coming fourth industrial revolution. Nevertheless, disordered Li deposition easily causes short lifespan and safety concerns and thus severely hinders the practical applications of Li metal batteries. Tremendous efforts are devoted to understanding the mechanism for Li deposition, while the final deposition morphology tightly relies on the Li nucleation and early growth. Here, the recent progress in insightful and influential models proposed to understand the process of Li deposition from nucleation to early growth, including the heterogeneous model, surface diffusion model, crystallography model, space charge model, and Li‐SEI model, are highlighted. Inspired by the abovementioned understanding on Li nucleation and early growth, diverse anode‐design strategies, which contribute to better batteries with superior electrochemical performance and dendrite‐free deposition behavior, are also summarized. This work broadens the horizon for practical Li metal batteries and also sheds light on more understanding of other important metal‐based batteries involving the metal deposition process.
Nanoparticle‐Mediated Delivery of Inhaled Immunotherapeutics for Treating Lung Metastasis
Authors: Jin Qiutong , Zhu Wenjun , Zhu Jiafei , Zhu Junjie , Shen Jingjing , Liu Zhuang , Yang Yang , Chen Qian 
Published: January 2021

AbstractDespite the critical breakthrough achieved by immune checkpoint blockade (ICB), the clinical benefits are usually restricted by inefficient infiltration of immune cells and immune‐associated adverse effects. Noninvasive aerosol inhalation, as a definitive procedure for treatment of respiratory diseases, for ICB immunotherapy against lung metastasis, has not been realized to the best knowledge. Herein, an inhaled immunotherapeutic chitosan (CS)–antibody complex is developed for immunotherapy against lung cancer. In this system, CS is used as a carrier to assemble with anti‐programmed cell death protein ligand 1 (aPD‐L1) to enable efficient transmucosal delivery. Moreover, CS exhibits adjuvant effects to drive potent immune responses via activating the cyclic‐di‐GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) pathway. Interestingly, repeated inhalation of CS/aPD‐L1 complex can effectively activate the immune system by promoting the infiltration of different immune cells especially CD8+ T cells around tumor lesions, and finally prolongs the survival of mice to 60 days. Thus, the work presents a unique aerosol inhalation delivery system for ICB antibody, which is promising for immunotherapy against lung metastasis without the concern of systemic toxicity.
Principles, Functions, and Applications of Optical Meta‐Lens
Authors: Chen Mu Ku , Wu Yongfeng , Feng Lei , Fan Qingbin , Lu Minghui , Xu Ting , Tsai Din Ping 
Published: January 2021

AbstractA meta‐lens is an advanced flat optical device composed of artificial antennas. The amplitude, phase, and polarization of incident light can be engineered to satisfy the application requirements of meta‐lenses. Meta‐lenses can be designed to achieve a variety of functions, such as diffraction‐limited focusing, high focusing efficiency, and aberration correlation, which are useful in various application scenarios. This review focuses on the recent progress in meta‐lenses, from fundamentals to applications. The present challenges in this domain are summarized and future prospects are offered. The primary aim of this review is to provide the reader with a comprehensive understanding of meta‐lenses and potential inspiration for designing high‐performance meta‐lenses for feasible applications.
Thermally Drawn Stretchable Electrical and Optical Fiber Sensors for Multimodal Extreme Deformation Sensing
Authors: Zhang Yujing , Li Xiyuan , Kim Jongwoon , Tong Yuxin , Thompson Emily G. , Jiang Shan , Feng Ziang , Yu Li , Wang Jinhua , Ha Dong Sam , Sontheimer Harald , Johnson Blake N. , Jia Xiaoting 
Published: January 2021

AbstractHighly stretchable fiber sensors have attracted significant interest recently due to their applications in wearable electronics, human–machine interfaces, and biomedical implantable devices. Here, a scalable approach for fabricating stretchable multifunctional electrical and optical fiber sensors using a thermal drawing process is reported. The fiber sensors can sustain at least 580% strain and up to 750% strain with a helix structure. The electrical fiber sensor simultaneously exhibits ultrahigh stretchability (400%), high gauge factors (≈1960), and excellent durability during 1000 stretching and bending cycles. It is also shown that the stretchable step‐index optical fibers facilitate detection of bending and stretching deformation through changes in the light transmission. By combining both electrical and optical detection schemes, multifunctional fibers can be used for quantifying and distinguishing multimodal deformations such as bending and stretching. The fibers’ utility and functionality in sensing and control applications are demonstrated in a smart glove for controlling a virtual hand model, a wrist brace for wrist motion tracking, fiber meshes for strain mapping, and real‐time monitoring of multiaxial expansion and shrinkage of porcine bladders. These results demonstrate that the fiber sensors can be promising candidates for smart textiles, robotics, prosthetics, and biomedical implantable devices.
Aquivion–Poly(N‐vinylcarbazole) Holistic Flory–Huggins Photonic Vapor Sensors
Authors: Megahd Heba , Oldani Claudio , Radice Stefano , Lanfranchi Andrea , Patrini Maddalena , Lova Paola , Comoretto Davide 
Published: January 2021

AbstractA holistic detection system, in principle sensitive to any molecular species in the vapor phase is proposed. The sensor consists of a polymeric multilayered distributed Bragg reflector made of a perfluorinated polar polymer, Aquivion, and a nonpolar polymer, poly(N‐vinylcarbazole). Alternated layers of the two polymers provide a characteristic optical response that depends on the chemical species intercalating within the structure. Such differences arise from Flory–Huggins polymer–solvent interactions. Then, the presence of polar, nonpolar, and perfluorinated moieties in the structures, potentially, allows sensitivity to any molecular species, providing a detection system with no need for any additional chemical receptors. As a proof of concept, the study demonstrates the sensitivity of the sensor to very diverse classes of molecules in the vapor phase including perfluorinated, nonpolar hydrophobic, and hydrophilic species and the capability to distinguish them, even in binary mixtures. Additionally, a connection between the dynamic temporal response of the sensors and the chemical–physical properties of the analytes, their concentration, and effective diffusion coefficient within the polymer structure is revealed.
Bifunctional Ru‐loaded Porous Organic Polymers with Pyridine Functionality: Recyclable Catalysts for N‐Formylation of Amines with CO2 and H2
Authors: Zhang Kai , Zong Lingbo , Jia Xiaofei 
Published: January 2021

AbstractA series of pyridine functionalized porous organic polymers (POPs‐Py&PPh3) have been synthesized by polymerizing tris(4‐vinylphenyl)phosphane and 4‐vinylpyridine. The pyridine moieties in the copolymer materials contribute to CO2 adsorption and promote the subsequent conversion of CO2. The POP supported Ru catalyst (Ru/POP3‐Py&PPh3) shows a high catalytic activity (TON up to 710) in the N‐formylation of various primary and secondary amines with CO2/H2, affording the corresponding formamides in good yields (55–95%) under mild reaction conditions. The heterogeneous catalyst can be easily separated from the reaction system and reused for at least eight cycles in the N‐formylation of morpholine.magnified image
Visible‐Light‐Promoted Switchable Synthesis of C‐3‐Functionalized Quinoxalin‐2(1H)‐ones
Authors: Aganda Kim Christopher C. , Hong Boseok , Lee Anna 
Published: January 2021

AbstractA visible‐light‐promoted synthesis of quinoxalin‐2(1H)‐ones has been developed using 9‐mesityl‐10‐methylacridinium perchlorate as an organo‐photocatalyst. The atmosphere‐controlled method (Ar/air) enabled the selective synthesis of hydroxyl‐ and acyl‐containing quinoxalin‐2(1H)‐ones under mild reaction conditions without the use of any metal catalysts or toxic reagents. A fluorescent labelling experiment showed that hydroxyl‐containing quinoxalin‐2(1H)‐ones may have utility in various biological applications as potent fluorophores.magnified image