bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms
Authors: de Oliveira Lima Igor Gomes , Bispo James Romero Soares , da Silva Maurício Bernardo , de Oliveira Feitosa Alexya , dos Santos Ana Caroline Melo , Moreira Magna Suzana Alexandre , Passarini Michel Rodrigo Zambrano , Saraiva Câmara Paulo Eduardo Aguiar , Rosa Luiz Henrique , Oliveira Valéria Maia , de Queiroz Aline Cavalcanti , Duarte Alysson Wagner Fernandes 
Published: August 2021

Background:
L-asparaginase (L-ASNase, L-asparagine amidohydrolase, E.C.3.5.1.1) is an enzyme
with wide therapeutic applicability. Currently, the commercialized L-ASNase comes from mesophilic organisms,
presenting low specificity to the substrate and limitations regarding thermostability and active pH
range. Such factors prevent the maximum performance of the enzyme in different applications. Therefore, extremophilic
organisms may represent important candidates for obtaining amidohydrolases with particular characteristics
desired by the biotechnological market.

Objective:
The present study aims to carry out a technological prospecting of patents related to the L-asparaginases
derived from extremophilic organisms, contributing to pave the way for further rational investigation and
application of such enzymes.

Methods:
This patent literature review used six patents databases: The LENS, WIPO, EPO, USPTO, Patent Inspiration,
and INPI.

Results:
It was analyzed 2860 patents, and 14 were selected according to combinations of descriptors and study criteria.
Approximately 57.14% of the patents refer to enzymes obtained from archaea, especially from the speciesPyrococcus
yayanosii (35.71% of the totality).

Conclusion:
The present prospective study has singular relevance since there are no recent patent reviews for L-asparaginases,
especially produced by extremophilic microorganisms. Although such enzymes have well-defined applications,
corroborated by the patents compiled in this review, the most recent studies allude to new uses, such as the treatment
of infections. The characterization of the catalytic profiles allows us to infer that there are potential sources still
unexplored. Hence, the search for new L-ASNases with different characteristics will continue to grow in the coming
years and, possibly, ramifications of the technological routes will be witnessed.
Effects of Prokinetics on the Digestive Tract
Authors: Usai-Satta Paolo , Lai Mariantonia , Oppia Francesco , Cabras Francesco 
Published: August 2021

Background:
Functional gastrointestinal disorders account for at least a third of visits to
gastroenterology clinics. Despite pathophysiological complexity, impaired gut motility may be frequently
present in these disorders.

Introduction:
Prokinetics are a class of drugs that promote gastrointestinal motility, accelerate transit,
and potentially improve digestive symptoms. Several prokinetic agents with a great variety of mechanisms
of action are available.

Aim:
The purpose of this paper is to update our current knowledge about the efficacy and safety of prokinetics.

Methods:
A literature search on efficacy and safety of prokinetics was carried out using the online databases
of Pubmed, Medline, and Cochrane.

Results :
Based on the action of different receptors, prokinetics mainly comprise dopamine antagonists,
5HT4 agonists, motilin agonists, ghrelin agonists, and cholinergic agonists. Prokinetics have the
potential to improve motility function in all segments of the digestive tract, from the esophagus to the
colon. In particular, drug international agencies have approved antidopaminergic metoclopramide for
the treatment of gastroparesis and serotoninergic prucalopride for chronic constipation not responsive
to traditional laxatives. Arrhythmias by QT prolongation and galactorrhea by prolactin stimulation are
the more frequent side effects related to prokinetics use.

Conclusions:
Old and new prokinetics are effective in ameliorating digestive motility disorders and related
symptoms and are widely prescribed. Special attention should be paid to the potential adverse
events of these agents.
Validity and Reliability of the Self-administered Psycho-TherApy-SystemS (SELFPASS) Item Pool for the Daily Mood Tracking of Depressive Symptoms: Cross-sectional Web-Based Survey
Authors: Mayer Gwendolyn , Hummel Svenja , Gronewold Nadine , Oetjen Neele , Hilbel Thomas , Schultz Jobst-Hendrik 
Published: August 2021

Backgrounde-Mental health apps targeting depression have gained increased attention in mental health care. Daily self-assessment is an essential part of e-mental health apps. The Self-administered Psycho-TherApy-SystemS (SELFPASS) app is a self-management app to manage depressive and comorbid anxiety symptoms of patients with a depression diagnosis. A self-developed item pool with 40 depression items and 12 anxiety items is included to provide symptom-specific suggestions for interventions. However, the psychometric properties of the item pool have not yet been evaluated.ObjectiveThe aim of this study is to investigate the validity and reliability of the SELFPASS item pool.MethodsA weblink with the SELFPASS item pool and validated mood assessment scales was distributed to healthy subjects and patients who had received a diagnosis of a depressive disorder within the last year. Two scores were derived from the SELFPASS item pool: SELFPASS depression (SP-D) and SELFPASS anxiety (SP-A). Reliability was examined using Cronbach α. Construct validity was assessed through Pearson correlations with the Patient Health Questionnaire-9 (PHQ-9), the General Anxiety Disorder Scale-7 (GAD-7), and the WHO-5-Wellbeing-Scale (WHO-5). Logistic regression analysis was performed as an indicator for concurrent criterion validity of SP-D and SP-A. Factor analysis was performed to provide information about the underlying factor structure of the item pool. Item-scale correlations were calculated in order to determine item quality.ResultsA total of 284 participants were included, with 192 (67.6%) healthy subjects and 92 (32.4%) patients. Cronbach α was set to .94 for SP-D and α=.88 for SP-A. We found significant positive correlations between SP-D and PHQ-9 scores (r=0.87; P<.001) and between SP-A and GAD-7 scores (r=0.80; P<.001), and negative correlations between SP-D and WHO-5 scores (r=–0.80; P<.001) and between SP-A and WHO-5 scores (r=–0.69; P<.001). Increasing scores of SP-D and SP-A led to increased odds of belonging to the patient group (SP-D: odds ratio 1.03, 95% CI 1.01-1.05; P<.001; SP-A: 1.05, 1.05-1.01; P=.01). The item pool yielded 2 factors: one that consisted of mood-related items and another with somatic-related items.ConclusionsThe SELFPASS item pool showed good psychometric properties in terms of reliability, construct, and criterion validity. The item pool is an appropriate source for daily mood tracking in future e-mental health apps among patients with depression. Our study provides general recommendations for future developments as well as recommendations within the item pool.
NIÑOS DE LA CALLE: BUENOS AIRES SXXI
Authors: Brasesco María Verónica 
Published: August 2021

El estudio afronta la problemática del estatus de la infancia y la adolescencia contemporánea considerando especialmente el fenómeno del consumo de sustancias en niños de calle en la Ciudad de Buenos Aires. Se sustenta en una investigación realizada por la autora en el Observatorio de Drogas del Gobierno de la Ciudad Autónoma de Buenos Aires (GCABA): “Consumo de sustancias en niños de calle”. El objetivo del estudio de carácter cualitativo se basa en datos recogidos en cincuenta entrevista a niños de calle sobre el consumo de drogas, su funcionalidad y la valoración que los niños hacen del mismo.
Pengaruh motivasi dan kompetensi terhadap kinerja dosen tetap di sekolah tinggi pariwisata bali internasional denpasar
Authors: Gariyasa Ni Made Christina 
Published: August 2021

Kualitas akademik sebuah perguruan tinggi tidak lepas dari keberhasilannya menyelenggarakan Tri Dharma Perguruan Tinggi, yaitu Pendidikan, Penelitian dan Pengabdian Kepada Masyarakat. Perguruan Tinggi dituntut untuk terus mengembangkan tiga keunggulan, yaitu keunggulan dalam pendidikan, penelitian dan pengabdian kepada masyarakat terkait pemanfaatan dan penerapan ilmu pengetahuan, teknologi, dan seni (IPTEKS). Penelitian ini bertujuan untuk menganalisis efek motivasi dan kompetensi terhadap kinerja dosen tetap. Jumlah sampel dalam penelitian ini adalah 63 responden. Teknik pengumpulan data dalam penelitian ini adalah kuesioner dan dokumentasi. Pengambilan sampel menggunakan teknik sensus, yaitu teknik pengambilan sampel yang dilakukan pada tujuan dan pertimbangan tertentu. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif. Dalam analisis beberapa regresi linear yang diperoleh persamaan adalah Y = 4.048 + 0.204X1 + 0.238X2. Selain itu juga terbukti bahwa pengaruh motivasi terhadap kinerja Dosen Tetap di Sekolah Tinggi Pariwisata Bali Internasional merupakan efek positif dan signifikan, yang dibuktikan dengan adanya nilai probabilitas kurang dari 0,05 yaitu 0,04. Sedangkan pengaruh kompetensi terhadap kinerja Dosen Tetap di Sekolah Tinggi Pariwisata Bali Internasional menunjukkan efek positif dan signifikan, yang dibuktikan dengan adanya nilai probabilitas yang lebih kecil dari 0,05 yaitu 0,008. Untuk pengaruh motivasi dan kompetensi terhadap kinerja dosen tetap di Sekolah Tinggi Pariwisata Bali Internasional sebesar 39,9%.
International cooperation of S. I. Subbotin Institute Geophysics, NAS of Ukraine for 2010—2020
Authors: Starostenko V. I. , Rusakov O. M. , Yakimchik A. I. 
Published: August 2021

The geological structure of the lithosphere of the main tectonic structures has been refined for the territory of Ukraine and adjacent regions of Slovakia, Poland, Romania, Russia, as well as Bulgaria, the Antarctic Peninsula (West Antarctica) and Southeast Asia, and new data have been obtained on geophysical impacts that can affect the environment. A geodynamic scenario has been developed for the formation of large-scale folding of the Fore- Dobrudzja Trough, the South Ukrainian monocline and the Ingul block of the Ukrainian Shield, caused by tectonic events associated with the closing of the Paleotethys and Neotethys oceans in the Mesozoic. In the Pripyat-Dnieper-Donets Basin, the structure of the earth’s crust and upper mantle can reflect different intensities of rifting, from its passive stage in the Dnieper Graben to active rifting in the Pripyat Trough. An analysis of the geoelectric structure of the Earth’s crust in the Ukrainian Eastern Carpathians indicates that seismic events occur mainly in resistive solid rock domainswhich surrounded by aseismic high conductive zones consisting of at least partially melted material. The present-day mutual position of the Ukrainian shield and Fennoscandia stabilized 1720—1660 Ma. The age, distribution, orientation and composition have been studied for the LatePalaeoproterozoicdykes in the Volyn, Ingul and Azov blocks of the Ukrainian Shield. Eastern Crimea and the Sorokin Trough are fragments of a tectonic wedge formed after the Paleocene. The geothermal conditions of the Intra-Carpathian region are due to subduction during the closure of the Pannonian sea basin and the collisional interaction of the Eurasian plate with the microplates system of this region. In Bulgaria, most earthquakes occur outside high-resistive domains. The tectonic stages are reconstructed for the formation of the northern part of the Antarctic Peninsula in the Mesozoic-Cenozoic. The relationship has been established between the geomagnetic field and climate change, with it being different for the Northern and Southern Hemispheres. The results have been obtained within the framework of 25 international projects and 6 temporary international target teams of S. I. Subbotin Institute of Geophysics, NAS of Ukraine consisting of researchers from 23 countries. The results are presented in 53 publications, 38 of which are indexed in the Web of Scienct database, and 32 papers are published in 20 international journals and special publications of 10 countries with different impact factors (from 0,101 to 4,214), whose average impact factor is 3,341, and the total one is 66,815.
Motivation and Preferences of Human Resources in the Medical Field – Premises for Further Policies in the Medical Sector in Romania
Authors: Georgescu Mirela Cristina , Furtunescu Florentina Ligia , Frumusachi Otilia , Lopatica Lavinia , Mincă Dana Galieta 
Published: August 2021

Abstract
The health professionals might be driven by different reasons in choosing their future medical specialty like passion, personal interest, balance with the family life, financial expectation, prestige etc. Our study aimed to explore the dominant preferences of the medical students in choosing their medical specialty in relation to their personal profile. We analysed the options of 3424 students from three cohorts the biggest public medical university of Romania. We found that most of the medical student are very career oriented, with low interest in having a family or children during their student life, most are income-dependent by others, and driven by passion/interest in choosing their future specialty, but with low interest for family medicine. Our data could be relevant for the policy makers for tailoring the long-term human resources polices adapted to the students’ values, with the aim to assure an equitable coverage with medical services all over the country.
Tuberculosis and Covid-19 Co-Infection – Clinical Characteristics
Authors: Rădulescu Adriana 
Published: August 2021

Abstract
The threat of contagious infectious diseases is constantly evolving as demographic explosion, travel globalization and changes in human lifestyle increase the risk of speeding pathogens, leading to accelerate changes in disease landscape.(1) Tuberculosis and Covid-19 are both infectious diseases that attack primarily the lungs. Both diseases have similar symptoms such as cough, fever and difficulty breathing. Tuberculosis has a longer incubation period with a slower reset of disease. Experience on Covid-19 infection in TB patient remains limited. 8 studies reported a total of 80 patients with this co-infection. These patients were reported from 9 different countries, with Italy reporting the largest number of cases.(2) The aim of this study is to evaluate the characteristic of TB and Covid-19 co-infection in 10 patients who were admitted in the Pulmonology Hospital of Sibiu between 01.05.2020-30.04.2021. All of these patients were with nosocomial infection Covid-19 and were previously diagnosed with TB.
Minimal Individual Haemostasis (Mih) - Feasibility in Conventional and Distal Trans-Radial Approach
Authors: Mokbel Maged , Florescu Nicolae , Sinescu Crina Julieta 
Published: August 2021

Abstract
There is a growing use of trans-radial catheterisation for angiography and percutaneous interventions. The advantages of trans-radial over traditional femoral access include a decrease in the incidence of access site bleeding complications and improved patient comfort and recovery. Ensuring short haemostasis, which controls arterial bleeding after transracial interventions, but at the same time maintains radial arterial flow, appears to be the most important factor in reducing peri-procedural complications, especially radial artery occlusion (RAO). We evaluated the technical feasibility of our gradual deflation haemostasis method in a population of patients treated by both conventional and distal trans-radial approach, within 1 month period. A feasibility assessment was performed for 101 patients to assess whether our hemostasis technique could be performed safely. We concluded that our technique is feasible after trans-radial approach, in both categories of access, conventional or distal. The rate of peri-procedural complications was low and related to the type of approach used, with more positive results on the distal trans-radial approach.
Applications of Kinetotherapy in the Prophylaxis of Sedentary Behavior among Professions with a Medical Profile in the Field of Dentistry
Authors: Burcea Claudia-Camelia , Perieanu Viorel Ștefan , Costea Radu Cătălin , Burlibaşa Mihai , Chirilă Mihaela , Marcov Narcis , Tănase Gabriela , Măru Nicoleta , Farcaşiu Alexandru Titus , Milicescu Ștefan , Perieanu Mădălina Violeta , David Mihai , Ionescu Camelia , Marcov Elena-Cristina , Moraru Liliana 
Published: August 2021

Abstract
Sedentary behavior, both professional, occupational, leisure and recreational, is one of the major risk factors for cardio-metabolic health and premature mortality. But, this type of sedentary behavior can be found in many of the existing professional activities in 2021, among them being the professional activities with a medical profile in the field of dentistry: specific activities in the dentist’s office (and here we discuss about dentists and dental nurses) and activities specific in the dental laboratory (in this case, we are talking about dental technicians).
The Applicability of Functional Analysis in Fixed Prosthetics
Authors: Tătaru Cristina Adriana Dahm 
Published: August 2021

Abstract
Prost hetics is a field that requires a very good synergy between the dentist and the dental technician in order to create a prothetic treatment that is precise, functional and has also a good aesthetic. A good communication between the two parties is very important because, in most cases, dental technicians are located remotely and often do not see the patient. Functional analysis is an important requirement for diagnosing many different syndromes, which are usually associated with incorrect loading of the temporomandibular joint or dysfunctions. Fixed prosthesis focused on permanently attached (fixed) dentures. Such dental restorations, also called indirect restorations, include crowns, bridges (fixed prostheses), inlays, onlays and veneers. Fixed prosthesis can be used to restore one or more individual teeth, covering areas where the teeth have been lost. In general, the main advantages of fixed prosthetics compared to direct restorations are the superior strength when used in large restorations and the ability to build a tooth that has also a good aesthetic shape. As with any dental restoration, the principles used to determine Proper restoration involves taking into account the materials to be used, the extent of the tooth damage, the orientation and location of the teeth and the condition of the adjacent teeth.
The Impacts of Food Taboos and Preferences on Food Security in Developing Countries: Evidence from Ethiopia
Authors: Sewenet Alex , Schwarcz Pavol 
Published: August 2021

Abstract
Food norms are embodied within all the essential components of food security; availability, access, utilization, and stability. However, the adverse economic influences of these norms are largely under–researched in developing countries. Unique in its scoop, this study thus investigates the impacts of food taboos and preferences (FTP) on food security in Ethiopia, one of the world’s food–insecure nations combined with a culture of strict food norms. On the basis of a qualitative research design with semi–structured in–depth interviews, primary data was collected from eleven key informants of pertinent multidisciplinary backgrounds, experts and decision–makers. The empirical evidence revealed that religious and secular– based FTP have put significant restrictions on the efficient utilization of the existing edible resources in the country. For example, during Orthodox Christian (OC) and Muslim fasting days, the overall food supply chain undergoes economic turbulence. Particularly, the economic challenge of OC fasting is expressed by (1) a decrease in consumption and supply of non–vegan foods, (2) the temporary closure of butcher and dairy shops, (3) an increase in the demand and price of vegan foods, and (4) an overall reduction in consumption and economic transactions. Moreover, the tradition of animal consecration at home has made many Ethiopians to rarely depend on supermarkets, groceries, and other licensed meat shops. In turn, this impedes the country’s endeavor of attracting local and foreign private investors in the general food sector. It also alienates people from access to food labels, meat quality controls, price, size, and choice advantages, all of which are essential for better, adaptive, and stable food utilization. The results discovered in this thesis enrich our understanding on the role of food norms in the economic systems. Particularly, the study sheds light on the indispensable need to consider the subject of FTP in policies and programs aiming to end food insecurity.
Evaluation of Selected Indicators Pointing at the Current Condition and Importance of Agricultural Land Protection in Slovakia
Authors: Machničová Zina 
Published: August 2021

Abstract
Agricultural land is currently protected by many subjects and institutions. The characteristics of the soil in terms of its functions and importance for individuals or society from perspectives of several scientific disciplines is dealt with by several authors. The aim of the paper is to point out the current state and importance of the agricultural land protection in Slovakia in connection with the threats that affect its quantity and overall quality. The indicators as the area of agricultural land and the structure of the land fund, the evolution of agricultural land withdrawals for non-agricultural purposes and the current state or structure of legislation and institutions in the field of agricultural land protection in Slovakia were evaluated. The paper pointed out the important role of agricultural land in the country, as its area, especially with the majority of arable land and permanent grasslands, represents the majority of the total area of Slovakia. For several years, however, the volume of agricultural land has been steadily declining. This phenomenon is partly caused by the agricultural land withdrawals, which have now managed to stabilize at an average of 1000ha of withdrawn land per year. In Slovakia, there is currently a large number of legislative acts regulating the protection and agricultural land withdrawals, as well as a wide range of state and non-state institutions that operate in the field of agricultural land protection. The effectiveness of the implementation of legislation and the effectiveness of mutual cooperation of institutions seems questionable focusing on the current state of the land fund, which leads to the need to expand research on these aspects.
Heiter bis wolkig. Zum 50. Jubiläum des Hermannstädter Lehrstuhls für Germanistik
Authors: Sava Doris 
Published: August 2021

Abstract
German Studies in Hermannstadt (Sibiu) have always put an increased focus on preserving continuity and consistency in teaching and research. The international anniversary conference (October 2019) that marked 50 years since the establishment of the Chair of German Studies in Hermannstadt (Sibiu) offered ample opportunity for taking a retrospective look in order to reflect on continuities and ruptures. Thus, in the article are mentioned some of the challenges that the chair had to face in its recent history.