bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal stem cells derived from human induced pluripotent stem cells improve the engraftment of myogenic cells by secreting urokinase-type plasminogen activator receptor (uPAR)
Authors: Elhussieny Ahmed , Nogami Ken’ichiro , Sakai-Takemura Fusako , Maruyama Yusuke , Takemura Natsumi , Soliman Wael Talaat , Takeda Shin’ichi , Miyagoe-Suzuki Yuko 
Published: October 2021

Abstract
Background
Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disease caused by mutations in the dystrophin gene. Transplantation of myogenic stem cells holds great promise for treating muscular dystrophies. However, poor engraftment of myogenic stem cells limits the therapeutic effects of cell therapy. Mesenchymal stem cells (MSCs) have been reported to secrete soluble factors necessary for skeletal muscle growth and regeneration.

Methods
We induced MSC-like cells (iMSCs) from induced pluripotent stem cells (iPSCs) and examined the effects of iMSCs on the proliferation and differentiation of human myogenic cells and on the engraftment of human myogenic cells in the tibialis anterior (TA) muscle of NSG-mdx4Cv mice, an immunodeficient dystrophin-deficient DMD model. We also examined the cytokines secreted by iMSCs and tested their effects on the engraftment of human myogenic cells.

Results
iMSCs promoted the proliferation and differentiation of human myogenic cells to the same extent as bone marrow-derived (BM)-MSCs in coculture experiments. In cell transplantation experiments, iMSCs significantly improved the engraftment of human myogenic cells injected into the TA muscle of NSG-mdx4Cv mice. Cytokine array analysis revealed that iMSCs produced insulin-like growth factor-binding protein 2 (IGFBP2), urokinase-type plasminogen activator receptor (uPAR), and brain-derived neurotrophic factor (BDNF) at higher levels than did BM-MSCs. We further found that uPAR stimulates the migration of human myogenic cells in vitro and promotes their engraftment into the TA muscles of immunodeficient NOD/Scid mice.

Conclusions
Our results indicate that iMSCs are a new tool to improve the engraftment of myogenic progenitors in dystrophic muscle.
Non-stem bladder cancer cell-derived extracellular vesicles promote cancer stem cell survival in response to chemotherapy
Authors: Chung Wei-Min , Molony Ryan D. , Lee Yi-Fen 
Published: October 2021

Abstract
Background
Chemosenstive non-stem cancer cells (NSCCs) constitute the bulk of tumors and are considered as part of the cancer stem cell (CSC) niche in the tumor microenvironment (TME). Tumor-derived extracellular vesicles (EVs) mediate the communication between tumors and the TME. In this study, we sought to investigate the impacts of EVs released by NSCCs on the maintenance of CSC properties and chemoresistance.

Methods
We employed murine MB49 bladder cancer (BC) sub-lines representing CSCs and NSCCs as a model system. Chemotherapy drugs were used to treat NSCCs in order to collect conditioned EVs. The impacts of NSCC-derived EVs on CSC progression were evaluated through sphere formation, cytotoxicity, migration, and invasion assays, and by analyzing surface marker expression on these BC cells. Differential proteomic analyses were conducted to identify cargo protein candidates involved in the EV-mediated communication between NSCCs and CSCs.

Results
NSCC-derived EVs contained cargo proteins enriched in proteostasis-related functions, and significantly altered the development of CSCs such that they were more intrinsically chemoresistant, aggressive, and better able to undergo self-renewal.

Conclusions
We thus identified a novel communication mechanism whereby NSCC-EVs can alter the relative fitness of CSCs to promote disease progression and the acquisition of chemoresistance.
Reduced-complexity decoding implementation of QC-LDPC codes with modified shuffling
Authors: Hasani Alireza , Lopacinski Lukasz , Kraemer Rolf 
Published: October 2021

AbstractLayered decoding (LD) facilitates a partially parallel architecture for performing belief propagation (BP) algorithm for decoding low-density parity-check (LDPC) codes. Such a schedule for LDPC codes has, in general, reduced implementation complexity compared to a fully parallel architecture and higher convergence rate compared to both serial and parallel architectures, regardless of the codeword length or code-rate. In this paper, we introduce a modified shuffling method which shuffles the rows of the parity-check matrix (PCM) of a quasi-cyclic LDPC (QC-LDPC) code, yielding a PCM in which each layer can be produced by the circulation of its above layer one symbol to the right. The proposed shuffling scheme additionally guarantees the columns of a layer of the shuffled PCM to be either zero weight or single weight. This condition has a key role in further decreasing LD complexity. We show that due to these two properties, the number of occupied look-up tables (LUTs) on a field programmable gate array (FPGA) reduces by about 93% and consumed on-chip power by nearly 80%, while the bit error rate (BER) performance is maintained. The only drawback of the shuffling is the degradation of decoding throughput, which is negligible for low values of$$E_b/N_0$$Eb/N0until the BER of 1e−6.
A characterization of cortisol level and adrenal reservation in human cardiopulmonary arrest: systematic review and meta-analysis
Authors: Sahebnasagh Adeleh , Nejad Paria Soltani , Salehi-Abargouei Amin , Dehghani Mohammad Hossein , Saghafi Fatemeh 
Published: October 2021

Abstract
Background
Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.

Methods
We searched the following databases: PubMed, Scopus, ISI Web of Science, and Google Scholar. Relevant observational and controlled trials were explored from inception by April 2020. The quality of the articles was assessed using the Newcastle-Ottawa Scale (NOS).

Results
Finally, five cohort studies (n = 201 participants in total) were eligible for including in the meta-analysis. The results of this meta-analysis showed that although the baseline serum cortisol levels were higher in survivors of cardiac arrest compared with non-survivors, the differences between groups do not reach a significance level (Hedges’ g = 0.371, 95% CI, −0.727, 1.469, P value = 0.508). Between-study heterogeneity was statistically significant (Cochrane Q test: P value < 0.001, I2 = 89.323).

Conclusions
The result of the present meta-analysis was suggestive of a higher baseline serum cortisol levels in survivors of CPA. Future randomized controlled studies with a large sample size will determine the exact relationship between adrenal reservation and the eventual outcome of patients with CPA.

Systematic review registration
PROSPERO CRD42018085468
Do continuous forms of intra-operative ultrafiltration enhance recovery after adult cardiac surgery with cardiopulmonary bypass? A protocol for systematic review and meta-analysis of randomized controlled trials
Authors: Bierer Joel , Horne David , Stanzel Roger , Henderson Mark , Boulos Leah , Hayden Jill 
Published: October 2021

Abstract
Background
Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a systemic inflammatory syndrome that adversely impacts cardiopulmonary function and can contribute to prolonged postoperative recovery. Intra-operative ultrafiltration during CPB is a strategy developed by pediatric cardiac specialists, aiming to dampen the inflammatory syndrome by removing circulating cytokines and improving coagulation profiles during the cardiac operation. Although ultrafiltration is commonly used in the pediatric population, it is not routinely used in the adult population. This study aims to evaluate if randomized evidence supports the use of continuous intra-operative ultrafiltration to enhance recovery for adults undergoing cardiac surgery with CPB.

Methods
This systematic review and meta-analysis will include randomized controlled trials (RCT) that feature continuous forms of ultrafiltration during adult cardiac surgery with CPB, specifically assessing for benefit in mortality rates, invasive ventilation time and intensive care unit length of stay (ICU LOS). Relevant RCTs will be retrieved from databases, including MEDLINE, Embase, CENTRAL and Scopus, by a pre-defined search strategy. Search results will be screened for inclusion and exclusion criteria by two independent persons with consensus. Selected RCTs will have study demographics and outcome data extracted by two independent persons and transferred into RevMan. Risk of bias will be independently assessed by the Revised Cochrane Risk-of-Bias (RoB2) tool and studies rated as low-, some-, or high- risk of bias. Meta-analyses will compare the intervention of continuous ultrafiltration against comparators in terms of mortality, ventilation time, ICU LOS, and renal failure. Heterogeneity will be measured by the χ2 test and described by the I2 statistic. A sensitivity analysis will be completed by excluding included studies judged to have a high risk of bias. Summary of findings and certainty of the evidence, determined by the GRADE approach, will display the analysis findings.

Discussion
The findings of this systematic review and meta-analysis will summarize the evidence to date of continuous forms of ultrafiltration in adult cardiac surgery with CPB, to both inform adult cardiac specialists about this technique and identify critical questions for future research in this subject area.

Systematic review registration
This systematic review and meta-analysis is registered in PROSPERO CRD42020219309 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020219309).
Multi-resolution wavelet basis for solving steady forced Korteweg–de Vries model
Authors: Utudee Somlak , Maleewong Montri 
Published: October 2021

AbstractA steady forced Korteweg–de Vries (fKdV) model which includes gravity, capillary, and pressure distributions is solved numerically using the wavelet Galerkin method. The anti-derivatives of Daubechies wavelets are developed as the basis of the solution subspaces for the mixed boundary condition type. Accuracy of numerical solutions can be improved by increasing the number of wavelet levels in the multi-resolution analysis. The theoretical result of convergence rate is also shown. The problem can be viewed as gravity-capillary wave flows over an applied pressure distribution. The flow regime can be characterized by subcritical, supercritical, and critical flows depending on the value of the Froude number. Trapped depression and elevation waves are found over the pressure distribution. For a near-critical flow regime, a generalized solitary wave with ripples is presented. This shows a capillary effect in balance to gravity and the pressure force on the free surface.
A new structure to n-dimensional trigonometric cubic B-spline functions for solving n-dimensional partial differential equations
Authors: Raslan K. R. , Ali Khalid K. , Mohamed Mohamed S. , Hadhoud Adel R. 
Published: October 2021

AbstractIn this paper, we present a new structure of the n-dimensional trigonometric cubic B-spline collocation algorithm, which we show in three different formats: one-, two-, and three-dimensional. These constructs are critical for solving mathematical models in different fields. We illustrate the efficiency and accuracy of the proposed method by its application to a few two- and three-dimensional test problems. We use other numerical methods available in the literature to make comparisons.
Qualitative analysis of a discrete-time phytoplankton–zooplankton model with Holling type-II response and toxicity
Authors: Khan Muhammad Salman , Samreen Maria , Aydi Hassen , De la Sen Manuel 
Published: October 2021

AbstractThe interaction among phytoplankton and zooplankton is one of the most important processes in ecology. Discrete-time mathematical models are commonly used for describing the dynamical properties of phytoplankton and zooplankton interaction with nonoverlapping generations. In such type of generations a new age group swaps the older group after regular intervals of time. Keeping in observation the dynamical reliability for continuous-time mathematical models, we convert a continuous-time phytoplankton–zooplankton model into its discrete-time counterpart by applying a dynamically consistent nonstandard difference scheme. Moreover, we discuss boundedness conditions for every solution and prove the existence of a unique positive equilibrium point. We discuss the local stability of obtained system about all its equilibrium points and show the existence of Neimark–Sacker bifurcation about unique positive equilibrium under some mathematical conditions. To control the Neimark–Sacker bifurcation, we apply a generalized hybrid control technique. For explanation of our theoretical results and to compare the dynamics of obtained discrete-time model with its continuous counterpart, we provide some motivating numerical examples. Moreover, from numerical study we can see that the obtained system and its continuous-time counterpart are stable for the same values of parameters, and they are unstable for the same parametric values. Hence the dynamical consistency of our obtained system can be seen from numerical study. Finally, we compare the modified hybrid method with old hybrid method at the end of the paper.
On a new four-dimensional model of memristor-based chaotic circuit in the context of nonsingular Atangana–Baleanu–Caputo operators
Authors: Deressa Chernet Tuge , Etemad Sina , Rezapour Shahram 
Published: October 2021

AbstractA memristor is naturally a nonlinear and at the same time memory element that may substitute resistors for next-generation nonlinear computational circuits that can show complex behaviors including chaos. A four-dimensional memristor system with the Atangana–Baleanu fractional nonsingular operator in the sense of Caputo is investigated. The Banach fixed point theorem for contraction principle is used to verify the existence–uniqueness of the fractional representation of the given system. A newly developed numerical scheme for fractional-order systems introduced by Toufik and Atangana is utilized to obtain the phase portraits of the suggested system for different fractional derivative orders and different parameter values of the system. Analysis on the local stability of the fractional model via the Matignon criteria showed that the trivial equilibrium point is unstable. The dynamics of the system are investigated using Lyapunov exponents for the characterization of the nature of the chaos and to verify the dissipativity of the system. It is shown that the supposed system is chaotic and it is significantly sensitive to parameter variation and small initial condition changes.
On backward problem for fractional spherically symmetric diffusion equation with observation data of nonlocal type
Authors: Long Le Dinh , Van Ho Thi Kim , Binh Ho Duy , Saadati Reza 
Published: October 2021

AbstractThe main target of this paper is to study a problem of recovering a spherically symmetric domain with fractional derivative from observed data of nonlocal type. This problem can be established as a new boundary value problem where a Cauchy condition is replaced with a prescribed time average of the solution. In this work, we set some of the results above existence and regularity of the mild solutions of the proposed problem in some suitable space. Next, we also show the ill-posedness of our problem in the sense of Hadamard. The regularized solution is given by the fractional Tikhonov method and convergence rate between the regularized solution and the exact solution under a priori parameter choice rule and under a posteriori parameter choice rule.
Species richness, phylogenetic diversity and phylogenetic structure patterns of exotic and native plants along an elevational gradient in the Himalaya
Authors: Manish Kumar 
Published: October 2021

Abstract
Background
So far, macroecological studies in the Himalaya have mostly concentrated on spatial variation of overall species richness along the elevational gradient. Very few studies have attempted to document the difference in elevational richness patterns of native and exotic species. In this study, this knowledge gap is addressed by integrating data on phylogeny and elevational distribution of species to identify the variation in species richness, phylogenetic diversity and phylogenetic structure of exotic and native plant species along an elevational gradient in the Himalaya.

Results
Species distribution patterns for exotic and native species differed; exotics tended to show maximum species richness at low elevations while natives tended to predominate at mid-elevations. Native species assemblages showed higher phylogenetic diversity than the exotic species assemblages over the entire elevational gradient in the Himalaya. In terms of phylogenetic structure, exotic species assemblages showed majorly phylogenetic clustering while native species assemblages were characterized by phylogenetic overdispersion over the entire gradient.

Conclusions
The findings of this study indicate that areas with high native species richness and phylogenetic diversity are less receptive to exotic species and vice versa in the Himalaya. Species assemblages with high native phylogenetic overdispersion are less receptive to exotic species than the phylogenetically clustered assemblages. Different ecological processes (ecological filtering in case of exotics and resource and niche competition in case of natives) may govern the distribution of exotic and native species along the elevational gradient in the Himalaya.
Distribution of crystalloid fluid infused during onset of anesthesia-induced hypotension: a retrospective population kinetic analysis
Authors: Hahn Robert G. 
Published: October 2021

Abstract
Background
Induction of anesthesia causes a drop in arterial pressure that might change the kinetics of infused crystalloid fluid. The aim of this report is to provide a mathematical view of how fluid distributes in this setting.

Methods
Data were retrieved from three studies where 76 patients (mean age 63 years, mean body weight 66 kg) had received approximately 1.1 L of Ringer’s solution over 60 min by intravenous infusion before and during induction of spinal, epidural, or general anesthesia. A population kinetic model was used to analyze the fluid distribution and its relationship to individual-specific factors. Frequent measurements of blood hemoglobin and the urinary excretion served as dependent variables.

Results
Before anesthesia induction, distribution to the extravascular space was threefold faster than elimination by urinary excretion. Both distribution and elimination of infused fluid were retarded in an exponential fashion due to the anesthesia-induced decrease in the mean arterial pressure (MAP). A decrease in MAP from 110 to 60 mmHg reduced the rate of distribution by 75% and the rate of elimination by 90%. These adaptations cause most of the infused fluid to remain in the bloodstream. Age, gender, type of anesthesia, and the use of ephedrine had no statistically significant effect on plasma volume expansion, apart from their possible influence on MAP.

Conclusion
The decrease in MAP that accompanies anesthesia induction depresses the blood hemoglobin concentration by inhibiting both the distribution and elimination of infused crystalloid fluid. The report provides mathematical information about the degree of these changes.
An outbreak investigation of Burkholderia cepacia infections related with contaminated chlorhexidine mouthwash solution in a tertiary care center in Turkey
Authors: Bilgin Hüseyin , Altınkanat Gelmez Gülşen , Bayrakdar Fatma , Sayın Elvan , Gül Fethi , Pazar Nazlı , Çulha Gülcan , Süzük Yıldız Serap , Cinel Ismail , Korten Volkan 
Published: October 2021

Abstract
Background
We report a nosocomial outbreak caused by Burkholderia cepacia that occurred among six patients admitted in the medical and surgical intensive care unit between 04 March 2019 and 02 April 2019 in Istanbul, Turkey.

Methods
The outbreak investigation was launched on 11 March 2019 five days after the detection of B. cepacia in four different patients. We defined potential reservoirs and started environmental screening. We sampled the liquid solutions used in patient care activities. Pulse-field gel electrophoresis (PFGE) was performed to determine the genetic relatedness of environmental and patient samples.

Results
Burkholderia cepacia was isolated in tracheal aspiration cultures of six patients. Three out of six patients developed healthcare-associated pneumoniae due to B. cepacia. Environmental cultures in the ICUs revealed B. cepacia growth in 2% chlorhexidine-gluconate mouthwash solution that been used in the colonized patients as well as in samples obtained from the unused products. PFGE revealed the patient and a specific batch of chlorhexidine mouthwash solution samples had a 96% similarity.

Conclusion
Contamination of medical solutions used in critical patient care could cause outbreaks and should be detected early by infection control teams.

Graphic abstract
Overuse of antibiotics in maternity and neonatal wards, a descriptive report from public hospitals in Dar es Salaam, Tanzania
Authors: Kakolwa Mwaka A. , Woodd Susannah L. , Aiken Alexander M. , Manzi Fatuma , Gon Giorgia , Graham Wendy J. , Kabanywanyi Abdunoor M. 
Published: October 2021

Abstract
Background
Overuse of antibiotics is a major challenge and undermines measures to control drug resistance worldwide. Postnatal women and newborns are at risk of infections and are often prescribed prophylactic antibiotics although there is no evidence to support their universal use in either group.

Methods
We performed point prevalence surveys in three hospitals in Dar es Salaam, Tanzania, in 2018 to collect descriptive data on antibiotic use and infections, in maternity and neonatal wards.

Results
Prescribing of antibiotics was high in all three hospitals ranging from 90% (43/48) to 100% (34/34) in women after cesarean section, from 1.4% (1/73) to 63% (30/48) in women after vaginal delivery, and from 89% (76/85) to 100% (77/77) in neonates. The most common reason for prescribing antibiotics was medical prophylaxis in both maternity and neonatal wards.

Conclusions
We observed substantial overuse of antibiotics in postnatal women and newborns. This calls for urgent antibiotic stewardship programs in Tanzanian hospitals to curb this inappropriate use and limit the spread of antimicrobial resistance.