bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quaternary sodic and potassic intraplate volcanism in northeast China controlled by the underlying heterogeneous lithospheric structures
Authors: Fan Xingli , Chen Qi-Fu , Ai Yinshuang , Chen Ling , Jiang Mingming , Wu Qingju , Guo Zhen 
Published: July 2021

AbstractThe origin and mantle dynamics of the Quaternary intraplate sodic and potassic volcanism in northeast China have long been intensely debated. We present a high-resolution, three-dimensional (3-D) crust and upper-mantle S-wave velocity (Vs) model of northeast China by combining ambient noise and earthquake two-plane wave tomography based on unprecedented regional dense seismic arrays. Our seismic images highlight a strong correlation between the basalt geochemistry and upper-mantle seismic velocity structure: Sodic volcanoes are all characterized by prominent low seismic velocities in the uppermost mantle, while potassic volcanoes still possess a normal but thin upper-mantle “lid” depicted by high seismic velocities. Combined with previous petrological and geochemical research findings, we propose that the rarely erupted Quaternary potassic volcanism in northeast China results from the interaction between asthenospheric low-degree melts and the overlying subcontinental lithospheric mantle. In contrast, the more widespread Quaternary sodic volcanism in this region is predominantly sourced from the upwelling asthenosphere without significant overprinting from the subcontinental lithospheric mantle.
Earthquake doublet revealed by multiple pulses in lacustrine seismo-turbidites
Authors: Wils Katleen , Deprez Maxim , Kissel Catherine , Vervoort Morgan , Van Daele Maarten , Daryono Mudrik R. , Cnudde Veerle , Natawidjaja Danny H. , De Batist Marc 
Published: July 2021

AbstractEarthquake doublets have been described in fault systems around the world but have not yet been confidently resolved in paleoseismic records. Our current knowledge is limited to historical occurrences, preventing researchers from uncovering potential patterns or recognizing common fault behavior. Identification of prehistoric doublets is thus of crucial importance for adequate seismic hazard assessment and risk mitigation. We developed a new methodology to reveal the sedimentary imprint of earthquake doublets in lacustrine paleoseismic records based on flow direction analysis in multipulsed turbidites, because the delayed arrival of turbidity currents originating from the same source location demonstrates the occurrence of individual triggering mechanisms. As grains tend to align in the presence of a flow, we analyzed flow directions by determining the dominant orientation of elongated grains using a combination of grain size, paleomagnetism, and high-resolution X-ray computed tomography. This methodology was applied to a turbidite deposited by the 2007 CE earthquakes in West Sumatra (Mw 6.4 and 6.3, 2 h apart), and it provides the first unmistakable sedimentary evidence for an earthquake doublet. We argue that this methodology has great potential to be applied to multipulsed turbidites in various subaquatic paleoseismic records and can reveal the occurrence of unknown earthquake sequences.
Physical activity of daily life of Bundeswehr soldiers: a cross-sectional study
Authors: Schilz Christin , Sammito S 
Published: July 2021

IntroductionActivity of daily life is an important key to maintaining and improving the health status. This is especially important for people in physically demanding jobs, such as firefighters, military and police.MethodsIn order to record the actual state of activity of daily life among soldiers, a step count measurement with a pedometer was carried out on 196 soldiers of the German Armed Forces over 7 days and supplemented by a questionnaire on lifestyle factors.ResultsThe subjects exceeded the recommended 7000–8000 steps per day, with the rank and file moving the least and the commissioned officers the most. It was also striking that the soldiers in the study moved an average of 2600 steps less per day on weekends than on weekdays.ConclusionsBased on these findings, targeted physical activity measures can be established for the identified target groups within the framework of corporate health management in order to ensure the physical fitness of soldiers on routine duty and on deployment.
Bioethics in humanitarian disaster relief operations: a military perspective
Authors: Davies James , Brockie A , Breeze J 
Published: July 2021

The ethical dilemmas faced every day by military personnel working within the NHS will potentially be very different to ones that will be faced in the wake of a humanitarian disaster. Allied to this the potentially differing objectives from military personnel when compared with other healthcare workers in these scenarios and a conflict of ethics could arise.Within this paper, the fundamentals of this conflict will be explored and how working within the military framework can affect clinical decisions. This is a paper commissioned as a part of the humanitarian and disaster relief operations special issue of BMJ Military Health.
Does app-based unguided self-management improve mental health literacy, patient empowerment and access to care for people with mental health impairments? Study protocol for a randomised controlled trial
Authors: Kerber André , Beintner Ina , Burchert Sebastian , Knaevelsrud Christine 
Published: July 2021

IntroductionMental disorders pose a huge burden to both individuals and health systems. Symptoms and syndromes often remain undetected and untreated, resulting in comorbidity and chronification. Besides limited resources in healthcare systems, the treatment-gap is—to a large extent—caused by within-person barriers impeding early treatment seeking. These barriers include a lack of trust in professionals, fear of stigmatisation, or the desire to cope with problems without professional help. While unguided self-management interventions are not designed to replace psychotherapy, they may support early symptom assessment and recognition by reducing within-person barriers. Digital self-management solutions may also reduce inequalities in access to care due to external factors such as regional unavailability of services.Methods and analysisApproximately 1100 patients suffering from mild to moderate depressive, anxiety, sleep, eating or somatisation-related mental disorders will be randomised to receive either a low-threshold unguided digital self-management tool in the form of a transdiagnostic mental health app or care as usual. The primary outcomes will be mental health literacy, patient empowerment and access to care while secondary outcomes will be symptom distress and quality of life. Additional moderator and predictor variables are negative life events, personality functioning, client satisfaction, mental healthcare service use and application of self-management strategies. Data will be collected at baseline as well as 8 weeks and 6 months after randomisation. Data will be analysed using multiple imputation and analysis of covariance employing the intention-to-treat principle, while sensitivity analyses will be based on different multiple imputation parameters and a per-protocol analysis.Ethics and disseminationApproval was obtained from the Ethics Committee of the Faculty of Educational Science and Psychology at the Freie Universität Berlin. The results will be submitted to peer-reviewed specialised journals and presented at national and international conferences.Trial registerationThe trial has been registered in the DRKS trial register (DRKS00022531);Pre-results.
Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study
Authors: Taube Janis M , Roman Kristin , Engle Elizabeth L , Wang Chichung , Ballesteros-Merino Carmen , Jensen Shawn M , McGuire John , Jiang Mei , Coltharp Carla , Remeniuk Bethany , Wistuba Ignacio , Locke Darren , Parra Edwin R , Fox Bernard A , Rimm David L , Hoyt Cliff 
Published: July 2021

BackgroundEmerging data suggest predictive biomarkers based on the spatial arrangement of cells or coexpression patterns in tissue sections will play an important role in precision immuno-oncology. Multiplexed immunofluorescence (mIF) is ideally suited to such assessments. Standardization and validation of an end-to-end workflow that supports multisite trials and clinical laboratory processes are vital. Six institutions collaborated to: (1) optimize an automated six-plex assay focused on the PD-1/PD-L1 axis, (2) assess intersite and intrasite reproducibility of staining using a locked down image analysis algorithm to measure tumor cell and immune cell (IC) subset densities, %PD-L1 expression on tumor cells (TCs) and ICs, and PD-1/PD-L1 proximity assessments.MethodsA six-plex mIF panel (PD-L1, PD-1, CD8, CD68, FOXP3, and CK) was rigorously optimized as determined by quantitative equivalence to immunohistochemistry (IHC) chromogenic assays. Serial sections from tonsil and breast carcinoma and non-small cell lung cancer (NSCLC) tissue microarrays (TMAs), TSA-Opal fluorescent detection reagents, and antibodies were distributed to the six sites equipped with a Leica Bond Rx autostainer and a Vectra Polaris multispectral imaging platform. Tissue sections were stained and imaged at each site and delivered to a single site for analysis. Intersite and intrasite reproducibility were assessed by linear fits to plots of cell densities, including %PDL1 expression by TCs and ICs in the breast and NSCLC TMAs.ResultsComparison of the percent positive cells for each marker between mIF and IHC revealed that enhanced amplification in the mIF assay was required to detect low-level expression of PD-1, PD-L1, FoxP3 and CD68. Following optimization, an average equivalence of 90% was achieved between mIF and IHC across all six assay markers. Intersite and intrasite cell density assessments showed an average concordance of R2=0.75 (slope=0.92) and R2=0.88 (slope=0.93) for breast carcinoma, respectively, and an average concordance of R2=0.72 (slope=0.86) and R2=0.81 (slope=0.68) for NSCLC. Intersite concordance for %PD-L1+ICs had an average R2value of 0.88 and slope of 0.92. Assessments of PD-1/PD-L1 proximity also showed strong concordance (R2=0.82; slope=0.75).ConclusionsAssay optimization yielded highly sensitive, reproducible mIF characterization of the PD-1/PD-L1 axis across multiple sites. High concordance was observed across sites for measures of density of specific IC subsets, measures of coexpression and proximity with single-cell resolution.
Machine learning approaches in predicting ambulatory same day discharge patients after total hip arthroplasty
Authors: Zhong Haoyan , Poeran Jashvant , Gu Alex , Wilson Lauren A , Gonzalez Della Valle Alejandro , Memtsoudis Stavros G , Liu Jiabin 
Published: July 2021

Background
With continuing financial and regulatory pressures, practice of ambulatory total hip arthroplasty is increasing. However, studies focusing on selection of optimal candidates are burdened by limitations related to traditional statistical approaches. Hereby we aimed to apply machine learning algorithm to identify characteristics associated with optimal candidates.

Methods
This retrospective cohort study included elective total hip arthroplasty (n=63 859) recorded in National Surgical Quality Improvement Program dataset from 2017 to 2018. The main outcome was length of stay. A total of 40 candidate variables were considered. We applied machine learning algorithms (multivariable logistic regression, artificial neural networks, and random forest models) to predict length of stay=0 day. Models’ accuracies and area under the curve were calculated.

Results
Applying machine learning models to compare length of stay=0 day to length of stay=1–3 days cases, we found area under the curve of 0.715, 0.762, and 0.804, accuracy of 0.65, 0.73, and 0.81 for logistic regression, artificial neural networks, and random forest model, respectively. Regarding the most important predictive features, anesthesia type, body mass index, age, ethnicity, white blood cell count, sodium level, and alkaline phosphatase were highlighted in machine learning models.

Conclusions
Machine learning algorithm exhibited acceptable model quality and accuracy. Machine learning algorithms highlighted the as yet unrecognized impact of laboratory testing on future patient ambulatory pathway assignment.
Phenotypic differences among wild passerine nestlings in relation to early-life rearing environment
Authors: Gómez Jesús , Morrissey Christy A. , Cabezas Sonia , Marchant Tracy A. , Clark Robert G. 
Published: July 2021

Subtle changes in stress physiology during critical developmental stages have been linked to long-term fitness; however, the biological processes and phenotypic responses to early-life rearing environments, such as anthropogenic land use conditions, have not been fully evaluated in insectivorous birds. We manipulated Tree Swallow (Tachycineta bicolor (Vieillot, 1808)) brood sizes at sites with contrasting agricultural land use to assess phenotypic changes in body condition and genetic and physiological biomarkers of stress during the sensitive nestling growth phase. We predicted that nestling swallows raised on cropland-dominated sites, especially those in enlarged broods, would have lower body condition, shorter telomeres, and higher feather corticosterone than nestlings raised in smaller broods at grassland sites. Body condition was highest among nestlings raised in reduced broods but was unrelated to land use. Telomere lengths tended to be shorter in nestlings from enlarged broods and at cropland sites. Corticosterone was not related to any factor. Locally abundant insect populations associated with wetlands may have dampened the effects and (or) parent swallows assumed higher costs of reproduction rather than passing these costs to nestlings. Results suggest that food or other environmental stressors could reduce fledgling survival via telomere shortening; a hypothesis that requires further investigation due to its potential importance to population viability in multiple declining aerial insectivore species.
Practical Model Checking on FPGAs
Authors: Cho Shenghsun , Patel Mrunal , Ferdman Michael , Milder Peter 
Published: July 2021

Software verification is an important stage of the software development process, particularly for mission-critical systems. As the traditional methodology of using unit tests falls short of verifying complex software, developers are increasingly relying on formal verification methods, such as explicit state model checking, to automatically verify that the software functions properly. However, due to the ever-increasing complexity of software designs, model checking cannot be performed in a reasonable amount of time when running on general-purpose cores, leading to the exploration of hardware-accelerated model checking. FPGAs have been demonstrated to be promising verification accelerators, exhibiting nearly three orders of magnitude speedup over software. Unfortunately, the “FPGA programmability wall,” particularly the long synthesis and place-and-route times, block the general adoption of FPGAs for model checking.
To address this problem, we designed a runtime-programmable pipeline specifically for model checkers on FPGAs to minimize the “preparation time” before a model can be checked. Our design of the successor state generator and the state validator modules enables FPGA-acceleration of model checking without incurring the time-consuming FPGA implementation stages, reducing the preparation time before checking a model from hours to less than a minute, while incurring only a 26% execution time overhead compared to model-specific implementations.
Avaliação do impacto do tempo de espera para admissão em Unidade de Terapia Intensiva no desfecho clínico do paciente crítico
Authors: Tessari Patricia , Longo Morgana , Mendes Mariana Laís , Floriano Maria Luiza , Fabre Larissa , Westphal Glauco Adrieno , Rosso Deorgelis 
Published: July 2021

Este estudo tem por base a premissa de que com um maior número de leitos de Unidade de Terapia Intensiva (UTI) disponíveis o tempo de espera para admissão em UTI é menor, o que resulta no melhor desfecho clínico, justificando, portanto, a importância do presente estudo. Objetivo: Avaliar se o tempo de espera no Departamento de Emergência até a admissão em UTI tem influência no desfecho clínico do paciente crítico. Metodologia: Estudo observacional, retrospectivo, do tipo antes e depois, realizado em um hospital público do município de Joinville/SC no ano de 2019. Foram incluídos os dados referentes aos pacientes adultos admitidos na UTI com até 72 horas de espera no Departamento de Emergência desde a chegada ao hospital. Comparou-se o último trimestre de 2017 (fase 1), período durante o qual havia 14 leitos de UTI no hospital, e último trimestre de 2018 (fase 2), período durante o qual havia 30 leitos de UTI. Resultados: Analisaram-se 173 prontuários elegíveis de 2017 e 2018. Houve diferença estatisticamente significativa no tempo decorrido na emergência até a admissão em UTI entre 2017 e 2018 (mediana de 22 vs. 15; p=0,0002). A diferença estatística também foi relevante para a mortalidade em até 24 horas após a admissão em UTI, comparando-se os dois anos em questão (9,61% vs. 2,47%; p=0,04). Não houve diferença estatística significante na mortalidade hospitalar entre 2017 e 2018 (34,6% vs. 35,5%; p=0,57). Também não houve diferença estatisticamente relevante entre os demais parâmetros analisados. Conclusão: Comparando-se 2017 a 2018, percebeu-se que o tempo de espera pelo leito de UTI diminuiu, bem como a mortalidade em até 24h da admissão intensiva. No entanto, isto não se refletiu na mortalidade hospitalar.
Fibrous Caps in Atherosclerosis Form by Notch-Dependent Mechanisms Common to Arterial Media Development
Authors: Martos-Rodríguez Carlos J. , Albarrán-Juárez Julián , Morales-Cano Daniel , Caballero Ainoa , MacGrogan Donal , de la Pompa José Luis , Carramolino Laura , Bentzon Jacob F. 
Published: July 2021

Objective:
Atheromatous fibrous caps are produced by smooth muscle cells (SMCs) that are recruited to the subendothelial space. We tested whether the recruitment mechanisms are the same as in embryonic artery development, which relies prominently on Notch signaling to form the subendothelial medial SMC layers.

Approach and Results:
Notch elements were expressed in regions of fibrous cap in human and mouse plaques. To assess the causal role of Notch signaling in cap formation, we studied atherosclerosis in mice where the Notch pathway was inactivated in SMCs by conditional knockout of the essential effector transcription factor RBPJ (recombination signal-binding protein for immunoglobulin kappa J region). The recruitment of cap SMCs was significantly reduced without major effects on plaque size. Lineage tracing revealed the accumulation of SMC-derived plaque cells in the cap region was unaltered but that Notch-defective cells failed to re-acquire the SMC phenotype in the cap. Conversely, to analyze whether the loss of Notch signaling is required for SMC-derived cells to accumulate in atherogenesis, we studied atherosclerosis in mice with constitutive activation of Notch signaling in SMCs achieved by conditional expression of the Notch intracellular domain. Forced Notch signaling inhibited the ability of medial SMCs to contribute to plaque cells, including both cap SMCs and osteochondrogenic cells, and significantly reduced atherosclerosis development.

Conclusions:
Sequential loss and gain of Notch signaling is needed to build the cap SMC population. The shared mechanisms with embryonic arterial media assembly suggest that the cap forms as a neo-media that restores the connection between endothelium and subendothelial SMCs, transiently disrupted in early atherogenesis.
The Double Mistaken Identity of Colonial Literature
Authors: Arenas Pacheco Carlos Diego 
Published: July 2021

Abstract
Although postcolonial approaches in world literature and translation studies have produced much necessary scholarship, they have in general disregarded the historical ‘native’ author and translator working in colonial or semicolonial settings. Studies on Urdu literature in the 19th century, for instance, focus mostly on the role of British Orientalists. Drawing upon Allen’s trans-indigenous project, I propose to read the historical ‘native’ text approaching it with a concept drawn from Amerindian ethnohistory: ‘double mistaken identity’ (DMI). While ‘native’ intellectuals might have unwittingly contributed to furthering the cause of Western colonialists, DMI allows for two perspectives to coexist in the ‘native’ text, one of which is a ‘native’, non-hybrid perspective. I take the failed colonial project in 16th-century Japan as a model, focusing on a translation that both Urdu and Japanese intellectuals undertook: that of Aesop’s Fables. There is a case for considering ‘native’ literature fully colonial, fully ‘native’, and fully global.
How effectively do drought indices capture health outcomes? An investigation from rural Australia
Authors: Austin Emma , Kiem Anthony S. , Rich Jane , Perkins David , Kelly Brian 
Published: July 2021

AbstractDrought is a global threat to public health. Increasingly, the impact of drought on mental health and wellbeing is being recognised. This paper investigates the relationship between drought and wellbeing to determine which drought indices most effectively capture wellbeing outcomes. A thorough understanding of the relationship between drought and wellbeing must consider the: (i) three aspects of drought (duration, frequency and magnitude); (ii) different types of drought (e.g. meteorological, agricultural, etc.); and (iii) the individual context of specific locations, communities and sectors. For this reason, we used a variety of drought types, drought indices, and time windows to identify the thresholds for wet and dry epochs that enhance and suppress impacts to wellbeing. Four postcodes in New South Wales (NSW), Australia are used as case studies in the analysis to highlight the spatial variability in the relationship between drought and wellbeing. The results demonstrate that the relationship between drought indices and wellbeing outcomes differs temporally, spatially and according to drought type. This paper objectively tests the relationship between commonly used drought indices and wellbeing outcomes to establish if current methods of quantifying drought effectively capture wellbeing outcomes. For funding, community programs and interventions to result in successful adaptation, it is essential to critically choose which drought index, time window and wellbeing outcome to use in empirical studies. The uncertainties associated with these relationships must be accounted for and it must also be realized that results will differ based on these decisions.