bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis
Authors: Dvorzhinskiy Aleksey , Perino Giorgio , Chojnowski Robert , van der Meulen Marjolein C. H. , Bostrom Mathias P. G. , Yang Xu 
Published: July 2021

Abstract. Introduction: Current methods of managing osteomyelitic voids
after debridement are inadequate and result in significant morbidity to
patients. Synthetic ceramic void fillers are appropriate for non-infected
bone defects but serve as a nidus of re-infection in osteomyelitis after
debridement. CERAMENT G (CG) is an injectable ceramic bone void filler which contains gentamicin and is currently being evaluated for use in
osteomyelitic environments after debridement due to its theoretical ability
to serve as a scaffold for healing while eliminating residual bacteria after
debridement through the elution of antibiotics. The goal of this study was
to evaluate (1) the rate of persistent infection and (2) new bone growth of
a debrided osteomyelitic defect in a rat model which has been treated with
either gentamicin-impregnated ceramic cement (CERAMENT G) or the
same void filler without antibiotics (CERAMENT, CBVF). Methods: Osteomyelitis was generated in the proximal tibia of
Sprague Dawley rats, subsequently debrided, and the defect filled with
either (1) CG (n=20), (2) CBVF (n=20), or (3) nothing (n=20). Each group
was euthanized after 6 weeks. Infection was detected through bacterial
culture and histology. Bone growth was quantified using microCT.
Results: Infection was not detected in defects treated with CG
as compared with 35 % of defects (7/20) treated with CBVF and 50 %
(10/20) of empty defects (p=0.001). Bone volume in the defect of
CG-treated rats was greater than the CBVF (0.21 vs. 0.17, p=0.021) and
empty groups (0.21 vs. 0.11, p<0.001) at 6 weeks after
implantation.
Conclusions: Ceramic void filler with gentamicin
(CERAMENT G) decreased the rate of persistent infection and
increased new bone growth as compared to the same void filler without
antibiotics (CERAMENT) and an empty defect in a rat model of debrided osteomyelitis.
Graduate student confidence following a for-credit systematic review course pilot
Authors: McGowan Bethany Sheriese , Reed Jason B , Kinkus Yatcilla Jane 
Published: July 2021

Background: In 2015, librarians at Purdue University began fielding requests from many disciplines to consult or collaborate on systematic review projects, and in 2016, health sciences librarians led the launch of a formal systematic review service. In 2019, Purdue University Libraries was reorganized as the Libraries and School of Information Studies (PULSIS) and assigned its own course designation, ILS. The increase in calls for systematic review services and the ability to teach ILS courses inspired the development of a credit-bearing ILS systematic review course.Case presentation: We designed, taught, and assessed a one-credit systematic review course for graduate students, using a backward-design course development model and applying self-determination theoretical concepts into lessons, assignments, and assessments. Using qualitative pre- and post-assessments, we discovered a variety of themes around student motivations, expectations, and preferences for the course. In quantitative post-class assessments, students reported improved confidence in all systematic review processes, with the highest confidence in their ability to choose and use citation management managers, describe the steps in the systematic review process, and understand the importance of a reproducible and systematic search strategy.Conclusions: We considered our pilot a success. Next steps include testing 2- and 3-credit- hour models and working to formally integrate the course into departmental and certificate curriculums. This case report provides a model for course design principles, learning outcomes, and assessments that librarians and library administrators can use to adjust their systematic review services.
Exploring data management content in doctoral nursing handbooks
Authors: Raszewski Rebecca , Goben Abigail H. , Dewey Bergren Martha , Jones Krista , Ryan Catherine , Steffen Alana , Vonderheid Susan C. 
Published: July 2021

Objective: While data management (DM) is an increasing responsibility of doctorally prepared nurses, little is understood about how DM education and expectations are reflected within student handbooks. The purpose of this study was to assess the inclusion of DM content within doctoral nursing student handbooks.Methods: A list of 346 doctoral programs was obtained from the American Association of Colleges of Nursing (AACN). Program websites were searched to locate program handbooks, which were downloaded for analysis. A textual review of 261 handbooks from 215 institutions was conducted to determine whether DM was mentioned and, if so, where the DM content was located. Statistical analysis was performed to compare the presence of DM guidance by type of institution, Carnegie Classification, and the type of doctoral program handbook.Results: A total of 1,382 codes were identified across data life cycle stages, most commonly in the handbooks’ project requirements section. The most frequent mention of DM was in relation to collecting and analyzing data; the least frequent related to publishing and sharing data and preservation. Significant differences in the frequency and location of codes were identified by program type and Carnegie Classification.Conclusions: Nursing doctoral program handbooks primarily address collecting and analyzing data during student projects. Findings suggest limited education about, and inclusion of, DM life cycle content, especially within DNP programs. Collaboration between nursing faculty and librarians and nursing and library professional organizations is needed to advance the adoption of DM best practices for preparing students in their future roles as clinicians and scholars.
Overlaps of multiple database retrieval and citation tracking in dementia care research: a methodological study
Authors: Hirt Julian , Bergmann Johannes , Karrer Melanie 
Published: July 2021

Objective: We aimed to determine overlaps and optimal combination of multiple database retrieval and citation tracking for evidence synthesis, based on a previously conducted scoping review on facilitators and barriers to implementing nurse-led interventions in dementia care.Methods: In our 2019 scoping review, we performed a comprehensive literature search in eight databases (CENTRAL, CINAHL, Embase, Emcare, MEDLINE, Ovid Nursing Database, PsycINFO, and Web of Science Core Collection) and used citation tracking. We retrospectively analyzed the coverage and overlap of 10,527 retrieved studies published between 2015 and 2019. To analyze database overlap, we used cross tables and multiple correspondence analysis (MCA).Results: Of the retrieved studies, 6,944 were duplicates and 3,583 were unique references. Using our search strategies, considerable overlaps can be found in some databases, such as between MEDLINE and Web of Science Core Collection or between CINAHL, Emcare, and PsycINFO. Searching MEDLINE, CINAHL, and Web of Science Core Collection and using citation tracking were necessary to retrieve all included studies of our scoping review.Conclusions: Our results can contribute to enhancing future search practice related to database selection in dementia care research. However, due to limited generalizability, researchers and librarians should carefully choose databases based on the research question. More research on optimal database retrieval in dementia care research is required for the development of methodological standards.
Diagnostic possibilities and limitations of urgent intraoperative pathologicanatomical studies in oncogynecology
Authors: Saevets V. V. , Shamanova A. Y. , Semenov Y. A. , Chizhovskaja A. V. 
Published: July 2021

Introduction. One of the variants of intravital pathological and anatomical diagnostics is intraoperative pathological and anatomical ("urgent") examination, which serves for tumor process verification. Urgent intraoperative pathological and anatomical examination is widely used when there are certain differential diagnostic difficulties and limitations of instrumental methods of examination.The purpose of the study — to analyze the possibilities, limitations and the accuracy of "urgent" pathologic and anatomical diagnostics in oncogynecological diseases. Materials and methods. We retrospectively analyzed medical records of 378 inpatients treated in the gynecologic oncology department of CHOKZO and NM for the period from January 2016 to January 2021. Results and discussion. Urgent histological examination was used to diagnose ovarian tumors (82%, n=310); to evaluate the extent of a tumor process in uterine body cancer, ovarian cancer, cervical cancer (peritoneal carcinomatosis, ingrowth into adjacent tissues and organs) (15%, n=57); less often to evaluate resection margin ablation in cervical cancer, uterine body cancer (3%, n=11). In a comparison of conclusions after urgent morphological examination and conduction of material, discrepancies were registered only in hypodiagnostic ovarian tumors (in 5.8% of all "urgent" ovarian tumor studies, n=18), when the question about the malignancy potential of a process cannot be reliably decided. The reliability of intraoperative morphological verification of the process is 94.2%. The sensitivity is 96%, specificity is 97%, which is consistent with the results of other studies. Conclusions. Intraoperative morphological diagnosis is a highly specific and highly sensitive method of investigation. There are limitations of this diagnostic method depending on the volume of tissue material, quality of cryostat sections, as well as tumor features (e.g., ovarian masses) consisting of heterologous morphological areas. A compliant, multidisciplinary approach is required to successfully meet the challenges of intraoperative examination.
Indicators of the psychoemotional state of palliative polymorbid cancer patients
Authors: Kharlamova U. V. , Kurchenkova О. V. , Abdalov A. О. , Shubina К. A. , Samodurov S. I. 
Published: July 2021

Introduction. Palliative care is aimed at maintaining and improving the quality of life of the patient. Without taking into account the psychosocial aspects, psychological rehabilitation is impossible in the conditions of a psychotraumatic situation of the disease.The aim of the study was to assess the psychoemotional state of polymorbid palliative cancer patients.Materials and methods. An observational, analytical, single-stage (cross-sectional) study was conducted, which included 74 cancer patients of a palliative profile. The patients underwent laboratory and instrumental examination. The following tests were evaluated: resilience (S. Maddy's method, D. A. Leontiev's adaptation), life-sense orientations, the level of subjective control, C. D. Spielberger, the severity of chronic pain syndrome; the value of the Charlson comorbidity index, the Karnovsky index (ECOG) was calculated.Results. The level of the comorbidity index was 3 [2; 5] points, the intensity of chronic pain syndrome-2 [2; 3] points, ECOG-2 [2; 3] points. In polymorbid cancer palliative patients, the presence of a belief in the impact of the struggle on the outcome of what is happening was revealed, however, patients are not always ready to act in a difficult situation. In the examined group, signs of dissatisfaction with their life in the present prevailed, the lack of sufficient freedom of choice, the existence of hope for recovery as a result of the actions of others, primarily doctors. The average (and in some cases high) level of situational and personal anxiety was noted. The association of the comorbidity index and the indicators of the life-meaning orientations test; the indicator of the general internality scale and the ECOG value; the glomerular filtration rate and the indicator of resilience, risk acceptance was revealed. A number of correlations between the indicators of the psychoemotional state and laboratory parameters (the level of hemoglobin, albumin, iron, C-reactive protein) were noted.Conclusion. In cancer patients with a palliative profile, signs of mental maladaptation were revealed. The average (and in some cases high) level of situational and personal anxiety was noted. The revealed number of correlations focuses on the role of chronic non-communicable diseases in aggravating the psychoemotional status of chronic polymorbid cancer palliative patients.
Oral squamous cell carcinoma in "young" patients
Authors: Fatkullin D. М. , Guz А. О. , Garev А. V. , Zaharov А. S. , Sokolova М. I. 
Published: July 2021

Aim of the study — to provide for medical oncologists and surgeon, who specialize in treatment of head and neck oncology patients, the most recent information about incidence and feature of oral squamous cell carcinoma (OSCC) in young patients.Material and мethods. Pubmed, ScienceDirect are used for literature search. Data of world literature published since 1983 till 2021 and contain information about incidence, epidemiology, clinic, treatment and prognosis in OSCC in young patients. The data of retrospective and prospective clinical trials were studied.Results. Determined the relevance of this problem and described incidence and epidemiology. Based on the analysis of the most recent publications, the authors provided data on clinical picture and modern approaches to the treatment and prognosis of OSCC in young patients by comparison with old patients.Conclusion. Over the past 30 years, the incidence of oral squamous cell carcinoma in young patients has been increasing worldwide while the incidence of classical oral cancer has been decreasing and no clear etiology has been identified. In this review we analyzed and synthesized the literature regarding early onset OSCC. Since 1983, the first assumptions about the uniqueness of the etiology and clinical picture of OSCC in young patients have appeared; till this day, this topic remains relevant for head and neck oncologists. Understanding the biology of the OSCC in young patients can be crucial in determining the prevention of disease, treatment and prognosis for patients.
A Person-centered Approach to Diagnosis and Care for Bipolar Disorder and Alcoholism
Authors: Salloum Ihsan M. 
Published: July 2021

Person-centered Medicine proposes the whole person in context, as the center and goal of clinical care and public health. Person-centered Integrative Diagnosis (PID) is an emerging model for conceptualizing the process of clinical diagnosis and care implementing the vision and goals of person-centered medicine. Person-centered Integrative Diagnosis entails a broader and deeper notion of diagnosis, beyond the restricted concept of nosological diagnosis and intends to provide the informational basis for person-centered organization of health care. It involves the dynamic integration of both positive health and ill health and emphasizes the formulation of the health status through true partnership with interactive participation and engagement of clinicians, patients, and families using all relevant descriptive tools (categorization, dimensions, and narratives). The applicability of this model to chronic, complex comorbidity with emphasis on the recovery process and health restoration is particularly pertinent. This paper focuses on the applicability of the PID to the challenging comorbidity of bipolar disorder and alcoholism. The PID provides an integrated formulation of multiple complex problems as well as positive aspects of health and strengths that are key to formulating and implementing personalized treatment and recovery plans.
Patient-perceived Resource Oriented Care at a German Dynamic Psychiatric Hospital: A Pilot Study
Authors: Burbiel Ilse , Barrera Andrea 
Published: July 2021

Günter Ammon’s Dynamic Psychiatry, since its introduction in the late 1960s, has always been a resource-oriented treatment theory and approach. The authors’ objective is to investigate the patients’ perception on and usefulness of the implementation of resource-oriented treatment in the psychiatric-psychotherapeutic practice of the Dynamic-Psychiatric Hospital Menterschwaige (Munich). The authors applied qualitatively and quantitatively structured questionnaires to 47 patients of different diagnostic groups. The results showed that the resource-oriented work was well received, positively used and experienced by the participating patients. Person-centered care appeared significantly present in the hospital’s therapeutic approach.
The GLADP-VR Person-centered Diagnostic Formulation: Back-ground, Concepts, and Structure
Authors: Mezzich Juan E , Otero Angel A. , Saavedra Javier E. , Salloum Ihsan M. 
Published: July 2021

A Revised Version of the Latin American Guide of Psychiatric Diagnosis (GLADP-VR) has been recently published by the Latin American Psychiatric Association (APAL) through its Diagnostic and Classification Section, in collaboration with the World Psychiatric Association (WPA) Section on Classification and Diagnostic Assessment, the International College of Person-centered Medicine (ICPCM), and the Institute of Spanish Speaking Psychiatrists (IPLE). This development has been grounded progressively on pioneering Latin American contributions to the systematization of psychiatric diagnosis, the series of Cuban Glossaries as adaptations of the International Classification of Diseases to local realities and needs, the WPA International Guidelines for Diagnostic Assessment, the original version of the GLADP, the ICPCM Person-centered Diagnostic (PID) Model, and the support and participation of the national psychiatric societies of Latin America.The GLADP-VR person-centered diagnostic formulation uses ICD-10 categories and codes for illness description in a culturally-informed manner and is aimed at implementing a diagnosis of whole health and not only of diseases. Its informational domains involve the following levels: Health Status (from disorders and disability to well-being, all assessed with standard categories and dimensions), Health Contributing Factors (risk factors and protective factors formulated with categories and narratives), and Health Experience and Expectations (formulated in a semi-structured and narrative manner). Completion of this diagnostic formulation is based on interactive engagement among clinicians, patients, and families. Formats for the GLADP-VR diagnostic formulation and accompanying clinical care plan are presented and illustrated with a clinical case.The GLADP-VR represents the first practical application of Person-centered Integrative Diagnosis (PID), employing culturally-annotated ICD-10 categories for use in a major region of the world. While the development of the GLADP-VR appears to have been well grounded conceptually and built on the experience of the regions' professional community, the task remains for the now published GLADP-VR to be empirically evaluated on its applicability and usefulness across Latin America and beyond.
European Experience with Shared Decision Making
Authors: Coulter Angela , Härter Martin Härter , Moumjid-Ferdjaoui Nora , Perestelo-Perez Lilisbeth , Van der Weijden Trudy 
Published: July 2021

Background: Shared decision making (SDM) is frequently advocated but not yet widely implemented in European countries. Experience suggests that various incentives must be in alignment to encourage wider uptake. Objectives: To assess readiness for mainstream implementation of SDM in five European countries. Methods: Qualitative assessment of clinical policies and the availability of various SDM support services in Germany, France, Spain, the Netherlands and the UK. Results: All five countries have research groups working on SDM, patient groups calling for its wider use, and ethical and professional standards indicating its desirability, but apart from a small number of demonstration projects, there is no evidence of a systematic approach to implementation in any of the countries as yet. Conclusions: Greater attention will need to be given to the provision of effective leadership, training and practical support if SDM is to become a regular feature of clinical practice in these countries.
Decision Aids in the United States: the Patient Response
Authors: Wexler Richard , Gerstein Bethany S. , Brackett Charles , Fagnan Lyle J. (LJ) , Fairfield Kathleen M. , Frosch Dominick L. , Lewis Carmen L. , Morrissey Lawrence , Simmons Leigh H. , Swieskowski David , Chang Yuchiao , Fowler Floyd J. , Barry Michael J. 
Published: July 2021

Background: In the United States and elsewhere, a growing chorus of voices is calling for the routine use of patient decision aids (DAs) and shared decision making (SDM) in day-to-day care. A frequently cited barrier to this approach is the belief that many patients will not be able to understand key clinical information and/or prefer to delegate decision making to providers. These beliefs, often held by providers, are thought to be particularly applicable to elderly and less educated patients.Objectives: To test the perception that older and less educated patients will not value or benefit from DAs.Research design: Self-administered questionnaires completed by patients after viewing DAs.Subjects: 3001 patients in six primary care practice sites facing one of sixteen common medical decisions.Measures: Amount of DA viewed, knowledge about medical tests or treatments, DA rating, and importance of receiving DAs from providers.Results: Across age and education level, higher self-reported exposure to the DAs was associated with higher knowledge scores. Those over 65 and those who had not attended college had knowledge gains at least has high as those in other groups. There were no statistically significant differences by age or education in patient assessment of the importance of using DAs.Conclusions: Patients in primary care settings in the U.S. learn from DAs, rate them highly, and believe that providers should make them available in ways that are mainly independent of patient age or formal education.
Review Dialogues as an Opportunity to Develop a Person-related Overall Diagnosis
Authors: Bahrs Ottomar , Henze Karl-Heinz , Lowenstein Franziska , Abholz Heinz-Harald , Ilse Katharina , Wilm Stefan , Bureick Gertrud , Heim Susanne 
Published: July 2021

Background: In the long-term care of patients with chronic conditions, the process aspect of treatment is rarely in the focus of general practitioner(GP)-patient interactions. A specific interaction tool, the Review Dialogue (RD), has been developed to integrate patients’ health-related problems/risks as well as coping strategies/resources and to agree upon shared treatment objectives. Research question: Do periodical RDs contribute to a better achievement of treatment objectives and do they arrive at an overall diagnosis (Balint)? Methods: GPs were randomized either into an intervention group (extra training and regular RD with 20 patients with chronic conditions) or into a control group (usual care). Videos of a sub-sample of patients (5 per practice) were taken at four points in time.This paper focuses on a sub-sample of 125 video-recorded GP-patient interactions, analysed using a semi-standardised procedure (RLI). An in-depth analysis of a maximum variation sample of eight GPs’ videotapes across four points in time was made to identify professional interaction strategies. Results: Implementing the RD and creating an overall holistic diagnosis is case-specific with respect to both, the GPs and the patients. Fostering individualised care RDs might contribute to a better achievement of treatment objectives. Conclusions: Review Dialogues facilitate the GP-patient communication process about diagnostics and therapy helping to make the implied overall diagnosis explicit. Further research is needed.