bluuebunny/crossref_metadata_2025_split huggingface dataset:
LITERATUR REVIEW:PENGETAHUAN IBU DALAM PEMBERIAN ASI PERAH (BREAST PUMPING) DENGAN TERCAPAINYA KEBUTUHAN ASI EKSLUSIF BAYI
Authors: Pringgayuda Fitra , Wijayanto Tri , Fitafiya Winda 
Published: November 2021

ASI merupakan makanan terbaik dan paling sempurna untuk bayi maka dari itu bayi usia 0-6 bulan hanya memerlukan ASI eksklusif tanpa tambahan lainya, pemberian ASI dapat dilakukan dengan cara breast pumbing metode ini digunakan bagi ibu yang bekerja diluar rumah untuk tetap memberikan ASI eksklusif pada anaknya. Tujuan : untuk menganalisis hubungan pengetahuan ibu dalam pemberian asi perah (breast pumping) dengan tercapainya kebutuhan asi ekslusif bayitahun 2020.Desain :Literature Review (LR). Sumber data : Database yang digunakan yaitu pubmed (tahun 2017 sd 2019) dan goole scholar (2013 sd 2019). Metode Review :pengetahuan, ASI eksklusif, breast pumping. Terdapat 25 artikel full teks dengan problem sesuai dengan kriteria inklusi yaitu hubunganpengetahuan Ibu Dalam Pemberian Asi Perah dengan tercapainya ASI eksklusif pada bayi, outcome ada hubungan ada hubungan pengetahuan Ibu Dalam Pemberian Asi Perah (Breast Pumping) dengan Tercapainya Kebutuhan Asi Ekslusif Bayi, desain studi cross-sectional dan tahun terbit mulai dari tahun 2013 dengan bahasa Indonesia dan bahasa inggris. Saran: Diharapkan para ibu untuk memberikan ASI secara eksklusif selama 6 bulan terutama ibu bekerja dengan cara breast pumping, hal ini bertujuan untuk memenuhi hak kesehatan anak dan menjaga asupan amakanan yang berkualitas bagi bayi usia 0-6 bulan yaitu ASI eksklusif
MEDIA BOOKLET DAN AUDIOVISUAL EFEKTIF TERHADAP PENGETAHUAN ORANGTUA DENGAN BALITA STUNTING
Authors: . Juniah , Apriliawati Anita , Sulaiman Suhendar 
Published: November 2021

Stunting merupakan salah satu karakteristik yang menandakan terjadinya masalah gizi yang berulang dan dalam waktu yang lama, sehingga diperlukan pengetahuan orangtua untuk merawat balita dengan stunting. Tujuan penelitian ini adalah menganalisis pengaruh edukasi merawat balita stunting melalui media booklet dan audiovisual terhadap pengetahuan orangtua. Metode penelitian quasi eksperimental dengan pre and post-testawithout control. Teknik pengambilan sampel purposive sampling dan analisis data menggunakan paired t-test. Populasi dalam penelitian ini adalah orangtua yang memiliki balita stunting dengan usia24 – 60 bulan di Puskesmas Kota Karang. Jumlahsampel (N) = 30terdiridari3kelompok, setiap kelompok terdapat 10 responden. Hasil penelitian terdapat perbedaan signifikan rata-rata pengetahuan (p=0,003) sebelum dan sesudah diberikan edukasi melalui media booklet. Terdapat perbedaan rata-rata pengetahuan (p=0,000) orangtua sebelum dan sesudah diberikanedukasi melalui media audiovisual. Terdapat perbedaan rata-rata pengetahuan (p=0,000) orangtua sebelum dan sesudah diberikan edukasi melalui media booklet dan audiovisual. Media booklet dan audiovisual lebih efektif dibandingkan dengan menggunakan media secara terpisah atau sendiri – sendiri. Oleh karena itu media booklet dan audiovisual yang digabungkan jadi satu saat penyuluhan atau pendidikan kesehatan dipelayanan kesehatan untuk meningkatkan pengetahuan orangtua dapat diterapkan.
Information networks – concept, classification and application
Authors: Salihović Nazif , Hasković Džubur Adisa 
Published: November 2021

An information network is a structure used for transmitting various forms and types of information. In basic structure, it consists of branches that connect certain nodes. Many scientists and researchers have dealt with the problem of defining an information network, depending on the functional organization and data transmission, and also with the classification of information networks. Information networks have a very wide application in almost all scientific disciplines. A large number of researches are carried out on the application of information networks (e.g. bisociative, deep information network, heterogeneous information network, and space information network) in the field of medicine for easier detection of diseases, drug development, etc, and other needs to support real-time communication, massive data transmission, and data processing. In accordance with the above mentioned, the aim of this paper is to offer different approaches in defining and classifying general forms of information networks and to notice their wide application in different research disciplines.
Reduction of Opioid Consumption After Outpatient Orthopaedic Trauma Surgeries Using a Multimodal Pain Protocol
Authors: Siow Matthew Y. , Mitchell Brendon C. , Vuong Carrie L. , Zanzucchi Audrey , Finneran John J. , Girard Paul J. , Schwartz Alexandra K. , Kent William T. 
Published: November 2021

Introduction:
Because of the dearth of literature in the orthopaedic trauma population, we aimed to analyze how a multimodal pain protocol after outpatient surgery affects opioid consumption, pain scores, and patient satisfaction.

Methods:
This was a cohort study with a historical control at an urban level 1 trauma center. Forty consecutive outpatients were given a peripheral nerve block and a multimodal pain protocol between September 2019 and March 2020 and compared with 70 consecutive preprotocol patients who received a peripheral nerve block and hydrocodone-acetaminophen. The primary outcome was morphine milligram equivalents (MMEs) consumed. Our secondary aims were pain scores and satisfaction.

Results:
Patients in the protocol were younger (36.45 versus 45.09 years, P = 0.007), butthere was no difference in sex, body mass index, American Society of Anesthesiologists, or surgical duration. There was a 59% reduction in opioids consumed in the first 4 days after surgery (3.83 MME versus 9.29 MME, P < 0.001). At the postoperative day-14 time point, protocol patients consumed a total of 5.59 MMEs, which is 40% less than just the first 4 days of the preprotocol (P = 0.02). Protocol patients assigned a higher rating of “least pain” on postoperative day 1 (1.24 versus 0.52, P = 0.04) but had higher satisfaction scores on day 1 (9.68 versus 8.54, P < 0.001) and day 2 (9.66 versus 8.61, P < 0.001).

Conclusion:
Implementation of a multimodal pain management protocol after outpatient orthopaedic trauma surgeries reduced opioid consumption by >50% in the first 4 days postoperatively. Additional studies are needed to refine the multimodal pain protocol used in this study.

Level of Evidence:
II
Orijentalni kultovi na tlu provincije Dalmacije u I stoljeću / Oriental cults in the province of Dalmatia in the 1st century
Authors: Hasagić Sanda 
Published: November 2021

The end of the Roman conquest of the territory inhabited by the Illyrian peoples entered the final phase of pacification with the end of the Great Illyrian revolt (6-9 AD). After the establishment of the government, the situation the Romans encountered in the province of Dalmatia was heterogeneous in terms of spiritual and material culture of the peoples that inhabited this territory. Oriental cults started to spread as the result of imperial propaganda, the army, merchants from the east, sailors, immigrants from eastern provinces, freedmen and slaves. The monuments that witness about the presence of the cult of Phrygian goddess Cybele and Egyptian goddess Isis date back to the 1st century AD in the territory of the province of Dalmatia. These cults had arrived to Rome centuries before whence they started to spread across the imperial provinces.
Radiation-induced basal cell carcinoma
Authors: Zargari Omid 
Published: November 2021

Background: The treatment of tinea capitis using radiotherapy was introduced at the beginning of the twentieth century. A variety of cancers including basal cell carcinoma (BCC) are seen years after this treatment.
Objective: We sought to determine the clinical characteristics of BCCs among irradiated patients.
Methods: The clinical records of all patients with BCC in a clinic in north of Iran were reviewed.
Results: Of the 58 cases of BCC, 29 had positive history for radiotherapy in their childhood. Multiple BCCs were seen in 79.3% and 10.3% of patients with history and without history of radiotherapy, respectively.
Conclusions: X-ray radiation is still a major etiologic factor in developing BCC in northern Iran. Patients with positive history for radiotherapy have higher rate of recurrence.
Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
Authors: Beutler Bryce D. , Cohen Philip R. 
Published: November 2021

Background: Taxanes [paclitaxel, nab-paclitaxel (Abraxane, Celgene Corp, USA), and docetaxel]—used in the treatment of lung, breast, and head and neck cancers—have been associated with cutaneous adverse effects, including photodermatoses.
Purpose: We describe a woman with non-small cell lung cancer who developed a photodistributed dermatitis associated with her nab-paclitaxel therapy and review photodermatoses in patients receiving taxanes.
Materials and methods: The features of a woman with a nab-paclitaxel-associated photodistributed dermatitis are presented and the literature on nab-paclitaxel-associated photosensitivity is reviewed.
Results: Our patient developed nab-paclitaxel-associated photodistributed dermatitis on the sun-exposed surfaces of her upper extremities, which was exacerbated with each course of nab-paclitaxel. Biopsies revealed an interface dermatitis and laboratory studies were negative for lupus erythematosus and dermatomyositis. Her condition improved following topical corticosteroid cream application and strict avoidance of sunlight.
Conclusion: Chemotherapy can be associated with adverse mucocutaneous events, including dermatoses on sun-exposed areas of the skin. Paclitaxel and nab-paclitaxel have both been associated with photodermatoses, including dermatitis, erythema multiforme, onycholysis, and subacute cutaneous lupus erythematosus. Strict avoidance of sun exposure, topical or oral corticosteroids, and/or discontinuation of the drug results in improvement with progressive resolution of symptoms and skin lesions. Development of photodermatoses is not an absolute contraindication to continuing chemotherapy, provided that the cutaneous condition resolves with dermatosis-directed treatment and the patient avoids sun exposure.
Long-chain fatty acids alter transcription of Helicobacter pylori virulence and regulatory genes
Authors: Valdez-Salazar Hilda A. , Ares Miguel A. , Fernández Francisco J. , Ibarra J Antonio , Torres Javier , Bustamante Víctor H. , De la Cruz Miguel A. 
Published: November 2021

Infection with Helicobacter pylori is one of the most important risk factors for developing gastric cancer (GC). The type IV secretion system (T4SS) encoded in the cag pathogenicity island is the main virulence factor of H. pylori associated with GC. Additionally, other virulence factors have been shown to play a role in the H. pylori virulence, such as vacuolizing cytotoxin (VacA), urease, flagella, and adhesins. Long-chain fatty acids (LCFAs) are signaling molecules that affect the transcription of virulence genes in several pathogenic bacteria such as Salmonella enterica, Vibrio cholerae, Pseudomonas aeruginosa and Mycobacterium tuberculosis. However, the effect of LCFAs on the transcription of H. pylori virulence and regulatory genes remains unknown. Here we analyzed whether the transcription of virulence genes that encode T4SS and cellular envelope components, flagellins, adhesins, toxins, urease, as well as the transcription of different regulatory genes of the H. pylori strain 26695, are altered by the presence of five distinct LCFAs: palmitic, stearic, oleic, linoleic, and linolenic acids. Palmitic and oleic acids up-regulated the transcription of most of the virulence genes tested, including cagL, cagM, flaB, sabA, mraY and vacA, as well as that of the genes encoding the transcriptional regulators NikR, Fur, CheY, ArsR, FlgR, HspR, HsrA, Hup, and CrdR. In contrast, the other LCFAs differentially affected the transcription of the virulence and regulatory genes assessed. Our data show that LCFAs can act as signaling molecules that control the transcription of the H. pylori virulome.
Efficacy of Oral Clonidine as Premedication on Intraoperative Bleeding and Consumption of Inhalational Agent in Patients Undergoing Functional Endoscopic Sinus Surgery
Authors: Chakole Vivek , Shankar Shilpa , Kota Sneha , Sen Jayashree , Madavi Sheetal , Vaishnav Devavrat 
Published: November 2021

Aim: To study the efficacy of oral clonidine on intraoperative bleeding and consumption of inhalational agent in patients undergoing FESS under general anesthesia.
Study Design: Prospective, comparative observational study.
Place and Duration of Study: Department of Anesthesiology, AVBRH, from June 2020 to May 2021.
Methodology: A total of 30 patients fulfilling inclusion criteria scheduled for FESS were randomly allocated into 2 groups of 15 each; GROUP C (Clonidine group, n=15) who received tab clonidine 5 mcg/kg, 90 minutes before surgery and GROUP M (Multivitamin group, n=15) who received multivitamin tablet. Mean ± standard deviation (SD) or absolute values were used to indicate data; comparison of qualitative data were done using Chi-square test and Fisher’s exact test and quantitative variables using the student ‘t’ Test. P value < 0.05 was taken as statistically significant.
Results: Bleeding was considerably less in the group C [1.65 ± 0.4] as compared to group M [2.20 ± 0.6] and is statistically significant [ P value = 0.006]. The mean MAC value (%) of sevoflurane consumption is lesser in the group C [1.25 ±0.25] than the group M [1.30 ±0.20] but not statistically significant (P value = 0.55). The mean dose (microgram) of fentanyl requirement was more in group M [ 120 ±20] than the group C [100 ± 25] and this was statistically significant (P value = 0.02).
Conclusion: Oral Clonidine can be used as an excellent premedication and provides cost effective method to attain controlled hypotension as there is lesser requirement of costly inhalational agent and other analgesic drugs. Also, it maintains better hemodynamic stability with fewer side effects.
Spatiotemporal Dynamic Assembly/Disassembly of Organelle‐Mimics Based on Intrinsically Disordered Protein‐Polymer Conjugates
Authors: Zhao Hang , Ibarboure Emmanuel , Ibrahimova Vusala , Xiao Ye , Garanger Elisabeth , Lecommandoux Sébastien 
Published: November 2021

AbstractDesign of reversible organelle‐like microcompartments formed by liquid–liquid phase separation in cell‐mimicking entities has significantly advanced the bottom‐up construction of artificial eukaryotic cells. However, organizing the formation of artificial organelle architectures in a spatiotemporal manner within complex primitive compartments remains scarcely explored. In this work, thermoresponsive hybrid polypeptide‐polymer conjugates are rationally engineered and synthesized, resulting from the conjugation of an intrinsically disordered synthetic protein (IDP), namely elastin‐like polypeptide, and synthetic polymers (poly(ethylene glycol) and dextran) that are widely used as macromolecular crowding agents. Cell‐like constructs are built using droplet‐based microfluidics that are filled with such bioconjugates and an artificial cytoplasm system that is composed of specific polymers conjugated to the IDP. The distinct spatial organizations of two polypeptide‐polymer conjugates and the dynamic assembly and disassembly of polypeptide‐polymer coacervate droplets in response to temperature are studied in the cytomimetic protocells. Furthermore, a monoblock IDP with longer length is concurrently included with bioconjugates individually inside cytomimetic compartments. Both bioconjugates exhibit an identical surfactant‐like property, compartmentalizing the monoblock IDP coacervates via temperature control. These findings lay the foundation for developing hierarchically structured synthetic cells with interior organelle‐like structures which could be designed to localize in desired phase‐separated subcompartments.
Informed cover measurement: Guidelines and error for point‐intercept approaches
Authors: Drezner Taly Dawn , Drezner Zvi 
Published: November 2021

AbstractPremiseThe point‐intercept method is one of the most commonly used approaches to measure species cover in ecosystems worldwide. In this approach, multiple points are sampled for presence/absence of a species, and the number of present points divided by the total number of sampled points provides an estimate of percent cover. Our purpose is to mathematically analyze the accuracy of the point‐intercept approach and establish guidelines for its use.MethodsWe developed formulas that analyze the point‐intercept method and confirmed their effectiveness using simulations.ResultsWe find that a point‐intercept spacing of at least 80% of the largest plant diameter provides the most reliable results. We present a user‐friendly spreadsheet that calculates the number of intercepts needed for fieldwork, as well as the standard deviation, expected deviation, and confidence interval of the collected data.DiscussionWe provide a variety of guidelines for establishing field protocols based on our results, including dealing with rare species and combining results for multiple species. Quadrat characteristics (intercept spacing, number of point intercepts) can now be easily calculated to guide research design prior to fieldwork; after fieldwork is complete, the accuracy of this technique can (and should) be reported in all future ecological studies in which it is used.
CAMSAP3 depletion induces lung cancer cell senescence‐associated phenotypes through extracellular signal‐regulated kinase inactivation
Authors: Wattanathamsan Onsurang , Chetprayoon Paninee , Chantaravisoot Naphat , Wongkongkathep Piriya , Chanvorachote Pithi , Pongrakhananon Varisa 
Published: November 2021

AbstractBackgroundCellular senescence is an aging‐related process found in cancer cells that contributes to irreversible growth arrest and tumor aggressiveness. Recently, calmodulin‐regulated spectrin‐associated protein 3 (CAMSAP3), a minus‐end microtubule‐stabilizing protein, has received increasing attention in cancer cell biology. However, the biological role of CAMSAP3 on senescence in human lung cancer remains incompletely understood.MethodsThe function of CAMSAP3 on the regulation of cellular senescence‐associated phenotypes in human non‐small cell lung cancer H460 cells were determined in CAMSAP3 deletion (H460/C3ko) cells. The effects of CAMSAP3 on cell proliferation were investigated using MTT and colony formation assays. The cell cycle activity was evaluated by flow cytometry and the senescence‐associated phenotypes were observed by SA‐β‐Gal staining. Quantitative RT‐PCR and westen blot were used to evaluate the expression of cell cycle and senescence markers. Moreover, the interaction of CAMSAP3‐ERK1/2 and possible partner protein was quantified using immunoprecipitation/mass spectrometry and immunofluorescence. Lastly, an xenograft model were performed.ResultsCAMSAP3 knockout promotes lung cancer cell senescence‐associated phenotypes and induces G1 cell cycle arrest. Mechanistic investigation revealed that phosphorylated ERK (p‐ERK) was markedly downregulated in CAMSAP3‐deleted cells, suppressing cyclin D1 expression levels, and full‐length CAMSAP3 abrogated these phenotypes. Proteomic analysis demonstrated that vimentin, an intermediate filament protein, is required as a scaffold for CAMSAP3‐modulating ERK signaling. Furthermore, an in vivo tumor xenograft experiment showed that tumor initiation is potentially delayed in CAMSAP3 knockout tumors with the downregulation of p‐ERK and cyclin D1, resulting in a senescence‐like phenotype.ConclusionThis study is the first to report an intriguing role of CAMSAP3 in lung carcinoma cell senescence‐associated phenotypes via the modulation of p‐ERK/cyclin D1 signaling.
Tear antibodies to SARS‐CoV‐2: implications for transmission
Authors: Selva Kevin J , Davis Samantha K , Haycroft Ebene R , Lee Wen Shi , Lopez Ester , Reynaldi Arnold , Davenport Miles P , Kent Helen E , Juno Jennifer A , Chung Amy W , Kent Stephen J 
Published: November 2021

AbstractObjectivesSARS‐CoV‐2 can be transmitted by aerosols, and the ocular surface may be an important route of transmission. Little is known about protective antibody responses to SARS‐CoV‐2 in tears after infection or vaccination. We analysed the SARS‐CoV‐2‐specific IgG and IgA responses in human tears after either COVID‐19 infection or vaccination.MethodsWe measured the antibody responses in 16 subjects with COVID‐19 infection for an average of 7 months before, and 15 subjects before and 2 weeks post‐Comirnaty (Pfizer‐BioNtech) vaccination. Plasma, saliva and basal tears were collected. Eleven pre‐pandemic individuals were included as healthy controls.ResultsIgG antibodies to spike and nucleoprotein were detected in tears, saliva and plasma from subjects with prior SARS‐CoV‐2 infection in comparison with uninfected controls. While receptor‐binding domain (RBD)‐specific antibodies were detected in plasma, minimal RBD‐specific antibodies were detected in tears and saliva. By contrast, high levels of IgG antibodies to spike and RBD, but not nucleoprotein, were induced in tears, saliva and plasma of subjects receiving 2 doses of the Comirnaty vaccine. Increased levels of IgA1 and IgA2 antibodies to SARS‐CoV‐2 antigens were detected in plasma following infection or vaccination but were unchanged in tears and saliva. Comirnaty vaccination induced high neutralising Abs in the plasma, but limited neutralising antibodies were detected in saliva or tears.ConclusionBoth infection and vaccination induce SARS‐CoV‐2‐specific IgG antibodies in tears. RBD‐specific IgG antibodies in tears were induced by vaccination but were not present 7 months post‐infection. This suggests the neutralising antibodies may be low in the tears late following infection.