bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromium-based metal organic framework for pipette tip micro-solid phase extraction: an effective approach for determination of methyl and propyl parabens in wastewater and shampoo samples
Authors: Kaykhaii Massoud , Hashemi Sayyed Hossein , Andarz Fariba , Piri Amin , Sargazi Ghasem 
Published: November 2021

Abstract
Background
A chromium-based metal organic framework was synthesized and employed as an efficient sorbent for pipette tip micro-solid phase extraction and preconcentration of parabens from wastewater and shampoo samples up to sub-ppb level before their spectrophotometric analysis.

Results
Factors affecting preconcentration including volume and type of solvent, amount of sorbent, number of extraction, and volume and pH of samples were optimized employing one-variable-at-a-time and response surface methodology. Obtained analytical characteristics of the method proves its usefulness for analysis of real samples. Linear range of the method for parabens was 1.0–200.0 μg/L. Detection limit of the protocol was 0.24 µg/L for propyl paraben and 0.25 µg/L for methyl paraben. Reproducibility of the protocol defined as % RSD was better than 5.78%. Synthesized adsorbent can be re-used for at least 20 extractions.

Conclusion
The method showed a good detection limit and precision for determination of methyl- and propyl-paraben in wastewater and shampoo samples.
Effect of mast cell stabilization on angiogenesis in primary and secondary experimental Trichinella spiralis infection
Authors: EL-Dardiry Marwa A. , Abdel-Aal Amany A. , Abdeltawab Magda S. A. , El-Sherbini Mona , Hassan Marwa A. , Abdel-Aal Asmaa A. , Badawi Manal , Anis Shady E. , Khaled Bahaa-Eldin A. , Al-Antably Abeer S. 
Published: November 2021

Abstract
Background
Mast cells are known to affect the primary and secondary immune responses against parasites, and this effect is partially mediated through the release of pro-angiogenic mediators. The aim of this study was to explore the effect of the mast cell stabilizer (MCS), ketotifen, with and without albendazole, an anti-parasitic prescription medicine, on the inflammatory response against Trichinella spiralis, with the overall aim to investigate its effect on angiogenesis accompanying nurse cell formation.

Methods
The effect of ketotifen and albendazole was explored in eight groups of female BALB/c mice. Four groups were sensitized with a small dose of T. spiralis larvae. The drug regimen was then applied to both sensitized (challenged) and non-sensitized mice. The parasite load was assessed by histopathological examination of the small intestine and muscle tissue, and angiogenesis was assessed by immunohistochemistry to determine the expression of vascular endothelial growth factor (VEGF).

Results
Sensitized mice showed a significantly lower parasite load and a more pronounced inflammatory response than mice receiving a single infective dose of T. spiralis larvae. All treated groups showed a significant reduction in parasite count compared to the control groups (groups IAa and IBa), reaching approximately an 98.8% reduction in adult parasite count in the sensitized group treated with albendazole (groups IIAb and IIBb). MCS significantly decreased the parasite count during both the intestinal or muscular phases, reduced tissue inflammation, and decreased local VEGF expression, both in the non-sensitized and sensitized groups.

Conclusion
Sensitization with a low dose of T. spiralis larvae was found to confer a partial protective immunity against re-infection and to positively affect the study outcomes, thus underlining the importance of vaccination, but after extensive studies. The anti-angiogenic effect of MCS protects against larval encystation during the muscle phase. The anti-angiogenic potential of albendazole suggests that the action of this anti-helminthic during trichinellosis is not confined to structural damage to the parasite cuticle but includes an effect on host immunopathological response.

Graphical Abstract
RETRACTED ARTICLE: Model and algorithm of innovation performance evaluation for coordination of supply and demand based on wireless sensor network
Authors: Zhao Ye , Li Beiwei 
Published: November 2021

AbstractIn recent years, with the continuous development and progress of wireless communication and sensors, people's production and life have also undergone tremendous changes. This article aims to apply wireless sensor networks to the construction of a supply–demand coordination innovation performance evaluation model, in order to improve its influence and application scope in real life. This paper deeply researches the architecture and node organization structure of wireless sensor network, and strengthens its theoretical foundation in the application of performance evaluation model. This paper designs performance evaluation indicators and compares performance evaluation methods at home and abroad based on the evaluation indicators, compares and analyzes the factor analysis method, fuzzy comprehensive evaluation method, comprehensive index evaluation method, etc., draws the advantages and disadvantages of each method, and uses them reasonably. The performance evaluation model constructed in this paper adopts the production function method and the analytic hierarchy process. According to the principles of scientificity, feasibility, and economy, the performance indicators for evaluating the balance of supply and demand are screened out, and score evaluation and comparison of each indicator are carried out. Finally, this paper analyzes the corporate performance evaluation index composition, model regression, sensor performance and performance evaluation scores, etc., and has a comprehensive application analysis of the model constructed in this paper. As can be seen from the overall score we selected five companies, enterprises composite score is 83.574, ranking first, followed by a score of 78.421.
Efficient binaural rendering of spherical microphone array data by linear filtering
Authors: Arend Johannes M. , Lübeck Tim , Pörschmann Christoph 
Published: November 2021

AbstractHigh-quality rendering of spatial sound fields in real-time is becoming increasingly important with the steadily growing interest in virtual and augmented reality technologies. Typically, a spherical microphone array (SMA) is used to capture a spatial sound field. The captured sound field can be reproduced over headphones in real-time using binaural rendering, virtually placing a single listener in the sound field. Common methods for binaural rendering first spatially encode the sound field by transforming it to the spherical harmonics domain and then decode the sound field binaurally by combining it with head-related transfer functions (HRTFs). However, these rendering methods are computationally demanding, especially for high-order SMAs, and require implementing quite sophisticated real-time signal processing. This paper presents a computationally more efficient method for real-time binaural rendering of SMA signals by linear filtering. The proposed method allows representing any common rendering chain as a set of precomputed finite impulse response filters, which are then applied to the SMA signals in real-time using fast convolution to produce the binaural signals. Results of the technical evaluation show that the presented approach is equivalent to conventional rendering methods while being computationally less demanding and easier to implement using any real-time convolution system. However, the lower computational complexity goes along with lower flexibility. On the one hand, encoding and decoding are no longer decoupled, and on the other hand, sound field transformations in the SH domain can no longer be performed. Consequently, in the proposed method, a filter set must be precomputed and stored for each possible head orientation of the listener, leading to higher memory requirements than the conventional methods. As such, the approach is particularly well suited for efficient real-time binaural rendering of SMA signals in a fixed setup where usually a limited range of head orientations is sufficient, such as live concert streaming or VR teleconferencing.
Duality theorems for nondifferentiable semi-infinite interval-valued optimization problems with vanishing constraints
Authors: Wang Haijun , Wang Huihui 
Published: November 2021

AbstractIn this paper, we study the duality theorems of a nondifferentiable semi-infinite interval-valued optimization problem with vanishing constraints (IOPVC). By constructing the Wolfe and Mond–Weir type dual models, we give the weak duality, strong duality, converse duality, restricted converse duality, and strict converse duality theorems between IOPVC and its corresponding dual models under the assumptions of generalized convexity.
New discussion on nonlocal controllability for fractional evolution system of order $1 < r < 2$
Authors: Mohan Raja M. , Vijayakumar Velusamy , Shukla Anurag , Nisar Kottakkaran Sooppy , Rezapour Shahram 
Published: November 2021

AbstractIn this manuscript, we deal with the nonlocal controllability results for the fractional evolution system of $1< r<2$
1
<
r
<
2
in a Banach space. The main results of this article are tested by using fractional calculations, the measure of noncompactness, cosine families, Mainardi’s Wright-type function, and fixed point techniques. First, we investigate the controllability results of a mild solution for the fractional evolution system with nonlocal conditions using the Mönch fixed point theorem. Furthermore, we develop the nonlocal controllability results for fractional integrodifferential evolution system by applying the Banach fixed point theorem. Finally, an application is presented for drawing the theory of the main results.
Well-posed conditions on a class of fractional q-differential equations by using the Schauder fixed point theorem
Authors: Samei Mohammad Esmael , Ahmadi Ahmad , Selvam A. George Maria , Alzabut Jehad , Rezapour Shahram 
Published: November 2021

AbstractIn this paper, we propose the conditions on which a class of boundary value problems, presented by fractional q-differential equations, is well-posed. First, under the suitable conditions, we will prove the existence and uniqueness of solution by means of the Schauder fixed point theorem. Then, the stability of solution will be discussed under the perturbations of boundary condition, a function existing in the problem, and the fractional order derivative. Examples involving algorithms and illustrated graphs are presented to demonstrate the validity of our theoretical findings.
A terrorism-based differential game: Nash differential game
Authors: Megahed Abd El-Monem A. 
Published: November 2021

AbstractIn this paper, we investigate the problem of combating terrorism by the government, which is one of the most serious problems that direct governments and countries. We formulate the problem and use the Nash approach of a differential game to obtain the optimal strategies for combating terrorism. We study the relationship between each of the government’ strategies and terrorism when the government is on the defensive (reactive), and we study when the government expects terrorist attacks and develops its strategies to combat terrorism. Also, we study the relationship between government activity and its strategies as well as government activity and the strategy of terrorist organizations.
Mathematical analysis of a fractional resource-consumer model with disease developed in consumer
Authors: Mezouaghi Abdelheq , Benali Abdelkader , Kumar Sunil , Djilali Salih , Zeb Anwar , Rezapour Shahram 
Published: November 2021

AbstractThe research presents a qualitative investigation of a fractional-order consumer-resource system with the hunting cooperation interaction functional and an infection developed in the resources population. The existence of the equilibria is discussed where there are many scenarios that have been distinguished as the extinction of both populations, the extinction of the infection, the persistence of the infection, and the two populations. The influence of the hunting cooperation interaction functional is also investigated where it can influence the existence of equilibria and their stability. A proper numerical scheme is used for building a proper graphical representation for the goal of confirming the theoretical results.
Non-genetic inheritance of environmental exposures: a protocol for a map of systematic reviews with bibliometric analysis
Authors: Macartney Erin L. , Drobniak Szymon M. , Nakagawa Shinichi , Lagisz Malgorzata 
Published: November 2021

Abstract
Background
Over the last few decades, we increasingly see examples of parental environmental experiences influencing offspring health and fitness. More recently, it has become clear that some non-genetic effects can be conferred across multiple generations. This topic has attracted research from a diversity of disciplines such as toxicology, biomedical sciences, and ecology, due to its importance for environmental and health issues, as well as ecological and evolutionary processes, with implications for environmental policies. The rapid accumulation of primary research has enabled researchers to perform systematic reviews (SRs), including meta-analyses, to investigate the generality of and sources of variation in non-genetic effects. However, different disciplines ask different questions and SRs can vary substantially in scope, quality, and terminology usage. This diversity in SRs makes it difficult to assess broad patterns of non-genetic effects across disciplines as well as determine common areas of interest and gaps in the literature. To clarify research patterns within the SR literature on non-genetic inheritance, we plan to create a map of systematic reviews as well as conduct bibliometric mapping (referred to as ‘research weaving’). We will address four key questions: first, what are the broad research patterns unifying the SR literature on non-genetic inheritance across disciplines? Second, are there discipline-specific research patterns, including terminology use, between disciplines? Third, how are authors of the SR literature connected? Fourth, what is the reliability of the SR literature?

Methods
We will systematically collect reviews within the SR ‘family’ that examine non-genetic inheritance arising from parental and ancestral environment by searching databases for journal articles and grey literature, as well as conducting backwards and forwards searching. Search hits will be double screened using ‘decision trees’ that represent the inclusion criteria. All relevant data elements on the review’s topic, as well as a critical appraisal of the review’s approach and reporting, will be extracted into Excel flat sheets. Bibliometric data will be directly extracted from Scopus. We will then query all relevant data elements to address our objectives and present outcomes in easily interpretable tables and figures, accompanied by a narrative description of results.
Efficacy of integrating short-course chemotherapy with Chinese herbs to treat multi-drug resistant pulmonary tuberculosis in China: a study protocol
Authors: Zhang Shun-Xian , Qiu Lei , Li Cui , Zhou Wei , Tian Li-Ming , Zhang Hui-Yong , Ma Zi-Feng , Wu Xian-Wei , Huang Xing , Jiang Yu-Wei , Zhang Shao-Yan , Lu Zhen-Hui 
Published: November 2021

Abstract
Background
Tuberculosis (TB) caused Mycobacterium tuberculosis (M.tb) is one of infectious disease that lead a large number of morbidity and mortality all over the world. Although no reliable evidence has been found, it is considered that combining chemotherapeutic drugs with Chinese herbs can significantly improves the cure rate and the clinical therapeutic effect.

Methods
Multi-drug resistant pulmonary tuberculosis (MDR-PTB, n = 258) patients with Qi-yin deficiency syndrome will be randomly assigned into a treatment group (n = 172) or control/placebo group (n = 86). The treatment group will receive the chemotherapeutic drugs combined with Chinese herbs granules (1 + 3 granules), while the control group will receive the chemotherapeutic drugs combined with Chinese herbs placebo (1 + 3 placebo granules). In addition, MDR-PTB (n = 312) patients with Yin deficiency lung heat syndrome will be randomly assigned to a treatment (n = 208) or control/placebo (n = 104) group. The treatment group will receive the chemotherapeutic regimen combined with Chinese herbs granules (2 + 4 granules), while the control group will receive the chemotherapeutic drugs and Chinese herbs placebo (2 + 4 placebo granules). The primary outcome is cure rate, the secondary outcomes included time to sputum culture conversion, lesion absorption rate and cavity closure rate. BACTEC™ MGIT™ automated mycobacterial detection system will be used to evaluate the M.tb infection and drug resistance. Chi-square test and Cox regression will be conducted with SAS 9.4 Statistical software to analyze the data.

Discussion
The treatment cycle for MDR-PTB using standardized modern medicine could cause lengthy substantial side effects. Chinese herbs have been used for many years to treat MDR-PTB, but are without high-quality evidence. Hence, it is unknown whether Chinese herbs enhances the clinical therapeutic effect of synthetic drugs for treating MDR-PTB. Therefore, this study will be conducted to evaluate the clinical therapeutic effect of combining Chinese herbs and chemotherapeutic drugs to treat MDR-PTB cases. It will assist in screening new therapeutic drugs and establishing treatment plan that aims to improve the clinical therapeutic effect for MDR-PTB patients.

Trial registration

This trial was registered at ClinicalTrials.gov (ChiCTR1900027720) on 24 November 2019 (prospective registered).

Graphical Abstract
BRAFV600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
Authors: Silver Jennifer A. , Bogatchenko Mariya , Pusztaszeri Marc , Forest Véronique-Isabelle , Hier Michael P. , Yang Ji Wei , Tamilia Michael , Payne Richard J. 
Published: November 2021

Background While some studies suggest that the BRAF V600E mutation correlates with a high-risk phenotype in papillary thyroid microcarcinoma (PTMC), more evidence is necessary before this mutation can be used to help guide decision making in the management of small thyroid nodules. This study investigated whether BRAF V600E mutation is associated with aggressive features in PTMC (≤ 1 cm) and small PTC (1–1.5 cm). Methods Retrospective chart review was performed on 121 patient cases. Patients who underwent thyroid surgery for PTMC (≤ 1 cm) or small PTC (1–1.5 cm) were included if molecular testing was done for BRAF V600E mutation. Two study groups were created based on tumour size: PTMC (n = 55) and small PTC (n = 66). The groups were analysed for the presence of a BRAF V600E mutation and aggressive features, including macroscopic extrathyroidal extension (ETE), lymph node metastasis (LNM), and high-risk histological features (tall cell, columnar cell, hobnail, solid/trabecular, and diffuse sclerosing). The Fischer exact test was used to calculate statistical significance. Results BRAF V600E mutations were detected in 43.6% of PTMC and 42.4% of small PTC. Of the mutated PTMC nodules, 54.1% demonstrated aggressive characteristics as compared to 19.4% of the non-mutated PTMCs ( p = 0.010). Of the mutated small PTC tumours, 82.1% had aggressive features. In contrast, 28.9% of the non-mutated small PTCs showed aggressive features ( p < 0.001). Conclusions Our findings demonstrate an association between a BRAF V600E mutation and aggressive features in PTMC (≤ 1 cm) and small PTC (1–1.5 cm). Therefore, determining the molecular status of these thyroid nodules for the presence of BRAF V600E can help guide patient management. Graphical Abstract
Smart education framework
Authors: Demir Kadir Alpaslan 
Published: November 2021

AbstractAdvances in information technologies present opportunities for novel approaches, methods, and tools for new or improved education and training practices. Furthermore, these technologies are enabling a shift in the education paradigm. Based on an investigation of a wide range of information technologies supporting smart education, we developed a Smart Education Framework. The framework conceptually structures the information technologies in a layered architecture. We also developed a smart education design approach based on the framework. Furthermore, we show how to use the framework and design approach to develop a specific course or lecture design. To validate the smart education framework, we examined smart education systems reported in the literature. To identify smart education systems, we conducted a systematic literature search. The literature search results show that the smart education framework has the ability to describe smart education systems. This study contributes to the current literature with a smart education framework. The smart education framework will guide future smart education system designs.
On the relationship between energy input to the ionosphere and the ion outflow flux under different solar zenith angles
Authors: Kitamura Naritoshi , Seki Kanako , Keika Kunihiro , Nishimura Yukitoshi , Hori Tomoaki , Hirahara Masafumi , Lund Eric J. , Kistler Lynn M. , Strangeway Robert J. 
Published: November 2021

AbstractThe ionosphere is one of the important sources for magnetospheric plasma, particularly for heavy ions with low charge states. We investigate the effect of solar illumination on the number flux of ion outflow using data obtained by the Fast Auroral SnapshoT (FAST) satellite at 3000–4150 km altitude from 7 January 1998 to 5 February 1999. We derive empirical formulas between energy inputs and outflowing ion number fluxes for various solar zenith angle ranges. We found that the outflowing ion number flux under sunlit conditions increases more steeply with increasing electron density in the loss cone or with increasing precipitating electron density (> 50 eV), compared to the ion flux under dark conditions. Under ionospheric dark conditions, weak electron precipitation can drive ion outflow with small averaged fluxes (~ 107 cm−2 s−1). The slopes of relations between the Poynting fluxes and outflowing ion number fluxes show no clear dependence on the solar zenith angle. Intense ion outflow events (> 108 cm−2 s−1) occur mostly under sunlit conditions (solar zenith angle < 90°). Thus, it is presumably difficult to drive intense ion outflows under dark conditions, because of a lack of the solar illumination (low ionospheric density and/or small scale height owing to low plasma temperature).
Graphical abstract