bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyanobacteria, cyanotoxins, and their histopathological effects on fish tissues in Fehérvárcsurgó reservoir, Hungary
Authors: Drobac Backović Damjana , Tokodi Nada , Marinović Zoran , Lujić Jelena , Dulić Tamara , Simić Snežana B. , Đorđević Nevena B. , Kitanović Nevena , Šćekić Ilija , Urbányi Béla , Meriluoto Jussi , Svirčev Zorica 
Published: August 2021

AbstractCyanobacteria are important members of lake plankton, but they have the ability to form blooms and produce cyanotoxins and thus cause a number of adverse effects. Freshwater ecosystems around the world have been investigated for the distribution of cyanobacteria and their toxins and the effects they have on the ecosystems. Similar research was performed on the Fehérvárcsurgó reservoir in Hungary during 2018. Cyanobacteria were present and blooming, and the highest abundance was recorded in July (2,822,000 cells/mL). The species present were Aphanizomenon flos-aquae, Microcystis flos-aquae, Microcystis wesenbergii, Cuspidothrix issatschenkoi, Dolichospermum flos-aquae, and Snowella litoralis. In July and September, the microcystin encoding gene mcyE and the saxitoxin encoding gene sxtG were amplified in the biomass samples. While a low concentration of microcystin-RR was found in one water sample from July, analyses of Abramis brama and Carassius gibelio caught from the reservoir did not show the presence of the investigated microcystins in the fish tissue. However, several histopathological changes, predominantly in gills and kidneys, were observed in the fish, and the damage was more severe during May and especially July, which coincides with the increase in cyanobacterial biomass during the summer months. Cyanobacteria may thus have adverse effects in this ecosystem.
Stable and momentary psychosocial correlates of everyday smoking: An application of Temporal Self-Regulation Theory
Authors: Jones Christopher M. , Schüz Benjamin 
Published: August 2021

AbstractSmoking is one of the leading causes of non-communicable disease mortality and morbidity. Smoking behaviour is determined by both stable, person-level (e.g., motivation, nicotine dependence) and variable, situation-level factors (e.g., urges, cues). However, most theoretical approaches to understanding health behaviours so far have not integrated these two spheres of influence. Temporal Self-Regulation Theory (TST) integrates these person-level and situation-level factors, but has not yet been comprehensively applied to predicting smoking behaviour. We use Ecological Momentary Assessment to examine the utility of TST in predicting daily smoking. 46 smokers reported individual and environmental cues right after smoking and at random time points during the day. Cognitions, self-control, past behaviour, and nicotine dependence were assessed at baseline. Multi-level logistic regressions show that smoking is largely guided by momentary cues, but individual motivation can buffer their influence. This suggests that TST is a useful integrative approach to understand modifiable determinants of smoking and thus intervention targets.
Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats
Authors: Kho Widuri , von Haefen Clarissa , Paeschke Nadine , Nasser Fatme , Endesfelder Stefanie , Sifringer Marco , González-López Adrián , Lanzke Nadine , Spies Claudia D. 
Published: August 2021

Abstract
Infections and perioperative stress can lead to neuroinflammation, which in turn is linked to cognitive impairments such as postoperative delirium or postoperative cognitive dysfunctions. The α2-adrenoceptor agonist dexmedetomidine (DEX) prevents cognitive impairments and has organo-protective and anti-inflammatory properties. Macroautophagy (autophagy) regulates many biological processes, but its role in DEX-mediated anti-inflammation and the underlying mechanism of DEX remains largely unclear. We were interested how a pretreatment with DEX protects against lipopolysaccharide (LPS)-induced inflammation in adult male Wistar rats. We used Western blot and activity assays to study how DEX modulated autophagy- and apoptosis-associated proteins as well as molecules of the cholinergic anti-inflammatory pathway, and qPCR to analyse the expression of autophagy and inflammation-associated microRNAs (miRNA) in the spleen, cortex and hippocampus at different time points (6 h, 24 h, 7 d). We showed that a DEX pretreatment prevents LPS-induced impairments in autophagic flux and attenuates the LPS-induced increase in the apoptosis-associated protein cleaved poly(ADP-ribose)-polymerase (PARP) in the spleen. Both, DEX and LPS altered miRNA expression and molecules of the cholinergic anti-inflammatory pathway in the spleen and brain. While only a certain set of miRNAs was up- and/or downregulated by LPS in each tissue, which was prevented or attenuated by a DEX pretreatment in the spleen and hippocampus, all miRNAs were up- and/or downregulated by DEX itself – independent of whether or not they were altered by LPS. Our results indicate that the organo-protective effect of DEX may be mediated by autophagy, possibly by acting on associated miRNAs, and the cholinergic anti-inflammatory pathway.

Graphical abstract
Preventive effects of DEX on LPS-induced inflammation. DEX restores the LPS-induced impairments in autophagic flux, attenuates PARP cleavage and alters molecules of the cholinergic system in the spleen. Furthermore, DEX alters and prevents LPS-induced miRNA expression changes in the spleen and brain along with LPS.
Good and bad boundaries in ultrasound compounding: preserving anatomic boundaries while suppressing artifacts
Authors: Hung Alex Ling Yu , Galeotti John 
Published: August 2021

AbstractPurposeUltrasound compounding is to combine sonographic information captured from different angles and produce a single image. It is important for multi-view reconstruction, but as of yet there is no consensus on best practices for compounding. Current popular methods inevitably suppress or altogether leave out bright or dark regions that are useful and potentially introduce new artifacts. In this work, we establish a new algorithm to compound the overlapping pixels from different viewpoints in ultrasound.MethodsInspired by image fusion algorithms and ultrasound confidence, we uniquely leverage Laplacian and Gaussian pyramids to preserve the maximum boundary contrast without overemphasizing noise, speckles, and other artifacts in the compounded image, while taking the direction of the ultrasound probe into account. Besides, we designed an algorithm that detects the useful boundaries in ultrasound images to further improve the boundary contrast.ResultsWe evaluate our algorithm by comparing it with previous algorithms both qualitatively and quantitatively, and we show that our approach not only preserves both light and dark details, but also somewhat suppresses noise and artifacts, rather than amplifying them. We also show that our algorithm can improve the performance of downstream tasks like segmentation.ConclusionOur proposed method that is based on confidence, contrast, and both Gaussian and Laplacian pyramids appears to be better at preserving contrast at anatomic boundaries while suppressing artifacts than any of the other approaches we tested. This algorithm may have future utility with downstream tasks such as 3D ultrasound volume reconstruction and segmentation.
Bariatric Surgery in Youth: the Perspective of Dutch Pediatricians, Parents, and Adolescents
Authors: van de Pas Kelly G. H. , Bonouvrie Daniëlle S. , Janssen Loes , Roebroek Yvonne G. M. , Zegers Bas S. H. J. , Leclercq Wouter K. G. , Vreugdenhil Anita C. E. , van Dielen François M. H. 
Published: August 2021

Abstract
Background
Recent studies have indicated that bariatric surgery is effective for the treatment of youth with severe obesity. The attitudes of pediatricians, parents, and adolescents regarding this topic remain unclear. Therefore, the aim of this study was to assess the current thoughts and beliefs of Dutch pediatricians, parents, and adolescents regarding bariatric surgery in youth.

Methods
An online survey containing twenty questions on bariatric surgery in youth was distributed to pediatricians of the Dutch Society of Pediatrics. Parents and adolescents who participated in an interdisciplinary care program for overweight, obesity, and severe obesity filled out an online survey of twelve questions.

Results
One hundred and twenty-one pediatricians, 49 parents, and 19 adolescents completed the surveys. Seventy-two pediatricians (59.5%) considered bariatric surgery to be an effective treatment for youth with severe obesity when conventional treatment fails, and intend to refer patients for bariatric surgery. The most frequently suggested conditions for bariatric surgery were a minimum age of 16 years (n = 59, 48.7%), a BMI threshold of 40 kg/m2 (n = 51, 42.2%), and a minimum Tanner stage of IV (n = 59, 48.8%).
Thirty parents (61.2%) and fourteen adolescents (73.7%) responded that bariatric surgery should become available for youth with severe obesity.

Conclusion
Dutch pediatricians, parents, and adolescents increasingly accept bariatric surgery as a treatment modality in youth with severe obesity who do not respond successfully to lifestyle intervention. Whether pediatricians will actually refer youth for bariatric surgery remains to be seen when this treatment option will be implemented in the Netherlands.

Graphical abstract
Examining Multilevel Poverty-Causing Factors in Poor Villages: a Hierarchical Spatial Regression Model
Authors: Wang Yanhui , Jiang Yuewen , Yin Duoduo , Liang Chenxia , Duan Fuzhou 
Published: August 2021

AbstractThe examination of poverty-causing factors and their mechanisms of action in poverty-stricken villages is an important topic associated with poverty reduction issues. Although the individual or background effects of multilevel influencing factors have been considered in some previous studies, the spatial effects of these factors are rarely involved. By considering nested geographic and administrative features and integrating the detection of individual, background, and spatial effects, a bilevel hierarchical spatial linear model (HSLM) is established in this study to identify the multilevel significant factors that cause poverty in poor villages, as well as the mechanisms through which these factors contribute to poverty at both the village and county levels. An experimental test in the region of the Wuling Mountains in central China revealed the following findings. (1) There were significant background and spatial effects in the study area. Moreover, 48.28% of the overall difference in poverty incidence in poor villages resulted from individual effects at the village level. Additionally, 51.72% of the overall difference resulted from background effects at the county level. (2) Poverty-causing factors were observed at different levels, and these factors featured different action mechanisms. Village-level factors accounted for 14.29% of the overall difference in poverty incidence, and there were five significant village-level factors. (3) The hierarchical spatial regression model was found to be superior to the hierarchical linear model in terms of goodness of fit. This study offers technical support and policy guidance for village-level regional development.
Increased risk of cancer in patients with primary sclerosing cholangitis
Authors: Lundberg Båve Aiva , Bergquist Annika , Bottai Matteo , Warnqvist Anna , von Seth Erik , Nordenvall Caroline 
Published: August 2021

Abstract
Background and aims
Primary sclerosing cholangitis (PSC) is associated with an increased risk of hepatobiliary and colorectal cancer, but the risks of other cancer forms have not been explored. The aim of this study was to evaluate the risk of intestinal and extraintestinal cancers in a large, well-defined cohort of PSC patients.

Material and method
A matched cohort study of Swedish PSC patients was performed with up to ten comparators for each patient, matched for sex, age, and residency. The data were retrieved from national registers. Patients were followed from PSC diagnosis until cancer diagnosis, liver transplantation, first emigration date, death, or December 31, 2016. The risk of cancer was estimated using the Kaplan–Meier method and Cox regression models.

Results
In total, 1432 PSC patients with a verified diagnosis and 14,437 comparators were studied. The mean follow-up time was 15.9 years. Eighty-eight percent of the PSC patients had concomitant inflammatory bowel disease. PSC patients ran significantly increased risks of developing any cancer [HR 3.8, 95% confidence interval (CI) 3.3–4.3], hepatobiliary cancer (HR 120.9, 95% CI 72.0–203.1), colorectal cancer (HR 7.5, 95% CI 5.6–10.0), pancreatic cancer (HR 8.0, 95% CI 3.2–20.2), gastric cancer (HR 4.2, 95% CI 1.5–11.3), small bowel cancer (HR 21.1, 95% CI 3.5–128.2), and lymphoma (HR 3.0, 95% CI 1.6–5.7). PSC was not associated with a lower risk of any cancer form.

Conclusions
PSC patients have a four times overall increased risk of developing cancer compared to the general population, with increased risk of developing hepatobiliary, colorectal, and pancreatic cancer, as well as lymphoma.
Altruism, Solidarity and Responsibility from a Committed Sociology: Contributions to Society
Authors: Gualda Estrella 
Published: August 2021

AbstractA careful look at the international development of Sociology highlights the centrality that the study of social problems and the approach to possible solutions to them have had in the history of this discipline, not infrequently for the sake of better social integration, stability, development, social change or even modernity. Recent approaches suggest shifting this focus of attention, arguing about the deficit in sociological research and practice concerning theor etical frameworks that pay attention to the positive aspects. This text reflects on the contributions that altruism, solidarity, and collective responsibility can have to improve the quality of life in contemporary societies and face humanitarian emergencies with a certain degree of success. For instance, the so-called refugee crisis or the current COVID-19 pandemic poses significant challenges for societies. This article also explores briefly new roles of data science in connection with responsibility and altruism. The text invites us to revisit sociology, thinking about the lights more than the shadows.
Comparative environmental sustainability study of an improved sewage sludge treatment and sludge reuse system based on emergy analysis in China
Authors: Zhang Junxue , Ma Lin 
Published: August 2021

AbstractAs the significant residuals in the sewage treatment system, sludge treatment and reuse play a pivotal impact on the environmental sustainability study in China. In this paper, two sewage sludge treatment systems have been investigated, calculated, and analyzed, including the conventional treatment system (Scenario A) and improved reuse system (Scenario B), respectively. The results demonstrate that (1) Compared to Scenario A, Scenario B is a comprehensive system, which integrates a sewage sludge treatment system and a brick production system for sludge recycling. (2) After considering the brick system (scenario B), on the one hand, the sludge treatment capacity has been enhanced and raised sludge utilization; on the other hand, negative influences have also generated due to the non-renewable resources input and several outputs. (3) In Scenario A and Scenario B, the input resources part reflects the main impact (about 59.6% in the entire emergy value). (4) In this new paper, the UEVs are 2.73E + 11sej/kg and 6.29E + 11sej/kg in Scenario A and Scenario B, respectively. (5) The emergy sustainability indexes (ESI) are 0.012292 and 0.00848, which express the weak comprehensive effects in Scenario A and Scenario B. (6) Scenario B has a more extensive range of change than Scenario A because of the more resource input for the sensitivity analysis. Given the all discussions, there are two effective approaches to be used for perfecting environmental sustainability in the Scenario A system and Scenario B system.
A novel technique for the modeling of shale swelling behavior in water-based drilling fluids
Authors: Lalji Shaine Mohammadali , Ali Syed Imran , Awan Zahoor Ul Hussain , Jawed Yunus 
Published: August 2021

AbstractOne of the most significant problems in oil and gas sector is the swelling of shale when it comes in contact with water. The migration of hydrogen ions (H+) from the water-based drilling fluid into the platelets of shale formation causes it to swell, which eventually increases the size of the shale sample and makes it structure weak. This contact results in the wellbore instability problem that ultimately reduces the integrity of a wellbore. In this study, the swelling of a shale formation was modeled using the potential of first order kinetic equation. Later, to minimize its shortcoming, a new proposed model was formulated. The new model is based on developing a third degree polynomial equation that is used to model the swelling percentages obtained through linear dynamic swell meter experiment performed on a shale formation when it comes in contact with a drilling fluid. These percentages indicate the hourly change in sample size during the contact. The variables of polynomial equation are dependent on the time of contact between the mud and the shale sample, temperature of the environment, clay content in shale and experimental swelling percentages. Furthermore, the equation also comprises of adjustable parameters that are fine-tuned in such a way that the polynomial function is best fitted to the experimental datasets. The MAE (mean absolute error) of the present model, namely Scaling swelling equation was found to be 2.75%, and the results indicate that the Scaling Swelling equation has the better performance than the first order kinetics in terms of swelling predication. Moreover, the proposed model equation is also helpful in predicting the swelling onset time when the mud and shale comes in direct contact with each other. In both the cases, the percentage deviation in predicting the swelling initiation time is close to 10%. This information will be extremely helpful in forecasting the swelling tendency of shale sample in a particular mud. Also, it helps in validating the experimental results obtained from linear dynamic swell meter.
Real world effectiveness and cost consequences of grass pollen SCIT compared with SLIT and symptomatic treatment
Authors: Brüggenjürgen Bernd , Klimek Ludger , Reinhold Thomas 
Published: August 2021

Abstract
Purpose
Real-world evidence (RWE) with regard to allergen-specific immunotherapy (AIT) adherence is increasingly available. Economic modelling has already shown AIT to be cost-effective in the treatment of allergic rhinitis compared with symptomatic treatment. However, analyzing sublingual (SLIT) and subcutaneous (SCIT) immunotherapeutic approaches based on RWE adherence data are not available for Germany. This analysis outlines the cost-effectiveness of SCIT compared with SLIT as well as a symptomatic treatment modality on the basis of recent RWE adherence data.

Methods
A Markov model, with predefined disease stages and a time period of 9 years, was adapted for this analysis. A 6-grass subcutaneous allergoid SCIT preparation and a 5-grass pollen SLIT tablet was employed as AIT administrations. Quality-adjusted life years (QALYs) were calculated based on symptom scores and used as the effectiveness variable. Total costs and cost effectiveness of SCIT, SLIT and symptomatic treatment (ST) were calculated. Model uncertainties were estimated by means of additional sensitivity analyses. Applied discount rate was 3%.

Results
Both SCIT and SLIT preparations proved superior compared to symptomatic treatment with regard to effectiveness. Although more expensive, AIT also proved to be cost-effective. A direct comparison of SCIT (Allergovit®) and SLIT (Oralair®) showed lower total costs for SCIT treatment over the study period of 9 years (SCIT 1779 € versus SLIT 2438 €) and improved effectiveness (SCIT 7.17 QALYs versus SLIT 7.11 QALYs).

Conclusion
AIT represents a cost-effective treatment option for patients with allergic rhinitis compared with symptomatic treatment. SCIT appeared to be dominant and cost-effective, due in particular to higher patient adherence and lower drug costs.
A Special Additive Enables All Cations and Anions Passivation for Stable Perovskite Solar Cells with Efficiency over 23%
Authors: Zhao Wenjing , Xu Jie , He Kun , Cai Yuan , Han Yu , Yang Shaomin , Zhan Sheng , Wang Dapeng , Liu Zhike , Liu Shengzhong 
Published: August 2021

AbstractPassivating undercoordinated ions is an effective way to reduce the defect densities at the surface and grain boundaries (GBs) of perovskite materials for enhanced photovoltaic performance and stability of perovskite solar cells (PSCs). Here, (BBF) complex is chosen as a multifunctional additive, which contains both C7H9N and BF3 groups working as Lewis base and Lewis acid, respectively, can bond with Pb2+/I− and FA+ on the surface and in the GBs in the perovskite film, affording passivation of both cation and anion defects. The synergistic effect of the C7H9N and BF3 complex slows the crystallization during the perovskite film deposition to improve the crystalline quality, which reduces the trap density and the recombination in the perovskite film to suppress nonradiative recombination loss and minimizes moisture permeation to improve the stability of the perovskite material. Meanwhile, such an additive improves the energy-level alignment between the valence band of the perovskite and the highest occupied molecular orbital of the hole-transporting material, Spiro-OMeTAD. Consequently, our work achieves power conversion efficiency of 23.24%, accompanied by enhanced stability under ambient conditions and light illumination and opens a new avenue for improving the performance of PSCs through the use of a multifunctional complex.
Continuous citrate‐capped gold nanoparticle synthesis in a two‐phase flow reactor
Authors: Damilos Spyridon , Alissandratos Ioannis , Panariello Luca , Radhakrishnan Anand N. P. , Cao Enhong , Wu Gaowei , Besenhard Maximilian O. , Kulkarni Amol A. , Makatsoris Charalampos , Gavriilidis Asterios 
Published: August 2021

AbstractA continuous manufacturing platform was developed for the synthesis of aqueous colloidal 10–20 nm gold nanoparticles (Au NPs) in a flow reactor using chloroauric acid, sodium citrate and citric acid at 95 oC and 2.3 bar(a) pressure. The use of a two-phase flow system – using heptane as the continuous phase – prevented fouling on the reactor walls, while improving the residence time distribution. Continuous syntheses for up to 2 h demonstrated its potential application for continuous manufacturing, while live quality control was established using online UV-Vis photospectrometry that monitored the particle size and process yield. The synthesis was stable and reproducible over time for gold precursor concentration above 0.23 mM (after mixing), resulting in average particle size between 12 and 15 nm. A hydrophobic membrane separator provided successful separation of the aqueous and organic phases and collection of colloidal Au NPs in flow. Process yield increased at higher inlet flow rates (from 70 % to almost 100 %), due to lower residence time of the colloidal solution in the separator resulting in less fouling in the PTFE membrane. This study addresses the challenges for the translation of the synthesis from batch to flow and provides tools for the development of a continuous manufacturing platform for gold nanoparticles.Graphical abstract