bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity
Authors: Park Seongjun , Yuk Hyunwoo , Zhao Ruike , Yim Yeong Shin , Woldeghebriel Eyob W. , Kang Jeewoo , Canales Andres , Fink Yoel , Choi Gloria B. , Zhao Xuanhe , Anikeeva Polina 
Published: June 2021

AbstractTo understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain limited by the foreign body response that stems from the chemo-mechanical mismatch between the probes and the neural tissues. To address this challenge, we developed a multifunctional sensing and actuation platform consisting of multimaterial fibers intimately integrated within a soft hydrogel matrix mimicking the brain tissue. These hybrid devices possess adaptive bending stiffness determined by the hydration states of the hydrogel matrix. This enables their direct insertion into the deep brain regions, while minimizing tissue damage associated with the brain micromotion after implantation. The hydrogel hybrid devices permit electrophysiological, optogenetic, and behavioral studies of neural circuits with minimal foreign body responses and tracking of stable isolated single neuron potentials in freely moving mice over 6 months following implantation.
Nanomolar phosphate supply and its recycling drive net community production in the subtropical North Pacific
Authors: Hashihama Fuminori , Yasuda Ichiro , Kumabe Aki , Sato Mitsuhide , Sasaoka Hiroshi , Iida Yosuke , Shiozaki Takuhei , Saito Hiroaki , Kanda Jota , Furuya Ken , Boyd Philip W. , Ishii Masao 
Published: June 2021

AbstractSeasonal drawdown of dissolved inorganic carbon (DIC) in the subtropical upper ocean makes a significant contribution to net community production (NCP) globally. Although NCP requires macronutrient supply, surface macronutrients are chronically depleted, and their supply has been unable to balance the NCP demand. Here, we report nanomolar increases in surface nitrate plus nitrite (N+N, ~20 nM) and phosphate (PO4, ~15 nM) from summer to winter in the western subtropical North Pacific. Molar ratios of upward fluxes of DIC:N+N:PO4to the euphotic zone (< 100 m) were in near-stoichiometric balance with microbial C:N:P ratios (107~243:16~35:1). Comparison of these upward influxes with other atmospheric and marine sources demonstrated that total supply is largely driven by the other sources for C and N (93~96%), but not for P (10%), suggesting that nanomolar upward supply of P and its preferential recycling play a vital role in sustaining the NCP.
Comparison of dynamic flow interaction methods between pipe system and overland in urban flood analysis
Authors: Hao Xiaoli , Li Yanmin , Liu Shu 
Published: June 2021

AbstractUrban flooding can be predicted by using different modeling approaches. This study considered different methods of modeling the dynamic flow interactions between pipe systems and surface flooding in urban areas. These approaches can be divided into two categories based on surface runoff collection units. This paper introduces a new hydrodynamic model that couples the storm water management model and the 2D overland model. The model’s efficiency was validated based on the aforementioned experimental dataset; agreement was verified by correlation values above 0.6. Additionally, this study used different approaches and compared their accuracy in predicting flooding patterns. The results show that the use of sub-catchments to model the collection of surface runoff was not predictive of the inundation process, indicating a lower goodness of fit with the recorded values than that of adopting cells. Moreover, to determine which method of adopting cells to collect runoff could better predict rainstorm-induced inundation, an error and correlation analysis was conducted. The analysis found low error and high correlation, suggesting that inundation can be effectively predicted by the new approaches. Ultimately, this study contributes to existing work on numerical analysis of the interaction methods of urban flooding.
Surface wave reflection from a metasurface termination
Authors: Berry S. J. , Hibbins A. P. , Sambles J. R. 
Published: June 2021

AbstractThe reflection coefficient of a microwave surface wave incident at the termination of a metasurface is explored. Two different surface types are examined. One is a square array of square metallic patches on a dielectric-coated metallic ground plane, the other a Sievenpiper ‘mushroom’ array. In the latter the surface wave fields are more confined within the structure. Comparison of the measured surface-wave reflection spectra is made with that obtained from analytic theory and numerical modelling. The reflection coefficient is shown to be dependent on both the momentum mismatch between the surface wave and the freely propagating modes as well as the different field distributions of the two modes.
Strain-tunable triple point Fermions in diamagnetic rare-earth half-Heusler alloys
Authors: Bhattacharya Anupam , Bhardwaj Vishal , Mani Brajesh K , Dutt Jayanta K , Chatterjee Ratnamala 
Published: June 2021

AbstractTopologically non-trivial electronic structure is a feature of many rare-earth half-Heusler alloys, which host atoms with high spin-orbit coupling bringing in the non-triviality. In this article, using the first-principles simulations, rare-earth half-Heusler YPdBi, ScPdBi, LaPdBi, LuPdBi, YPtBi and LuPtBi alloys are studied under strain to reveal multiple band inversions associated with topological phase transitions. From our simulations we find that, as a result of first band-inversion, the Brillouin zone of the diamagnetic half-Heusler alloys hosts eight triple points whereas, the second band inversion causes the emergence of sixteen more triple points. These band-inversions are observed to be independent of the spin-orbit coupling and are the reason behind increasing occupation of bismuth 7s orbitals as volume of the unit cell increases. The surface electronic transport in different triple point semi-metallic phases is found to evolve under strain, as the number of Fermi arcs change due to multiple band inversions. Once the second band inversion occurs, further application of tensile strain does not increase the number of triple points and Fermi arcs. However, increasing tensile strain (or decreasing compressive strain) pushes the triple point crossing to higher momenta, making them more effective as source of highly mobile electrons. These observations make a pathway to tune the bulk as well as surface transport through these semi-metals by application of tensile or compressive strain depending on the unstrained relative band-inversion strength of the material.
Regulatory properties of vitronectin and its glycosylation in collagen fibril formation and collagen-degrading enzyme cathepsin K activity
Authors: Date Kimie , Sakagami Hiromi , Yura Kei 
Published: June 2021

AbstractVitronectin (VN) is a glycoprotein found in extracellular matrix and blood. Collagen, a major extracellular matrix component in mammals, is degraded by cathepsin K (CatK), which is essential for bone resorption under acidic conditions. The relationship between VN and cathepsins has been unclear. We discovered that VN promoted collagen fibril formation and inhibited CatK activity, and observed its activation in vitro. VN accelerated collagen fibril formation at neutral pH. Collagen fibers formed with VN were in close contact with each other and appeared as scattered flat masses in scanning electron microscopy images. VN formed collagen fibers with high acid solubility and significantly inhibited CatK; the IC50 was 8.1–16.6 nM and competitive, almost the same as those of human and porcine VNs. VN inhibited the autoprocessing of inactive pro-CatK from active CatK. DeN-glycosylation of VN attenuated the inhibitory effects of CatK and its autoprocessing by VN, but had little effect on acid solubilization of collagen and VN degradation via CatK. CatK inhibition is an attractive treatment approach for osteoporosis and osteoarthritis. These findings suggest that glycosylated VN is a potential biological candidate for CatK inhibition and may help to understand the molecular mechanisms of tissue re-modeling.
Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer
Authors: Wang Qing , Liang Jiahong , Hu Xianyu , Gu Songgang , Xu Qiaodong , Yan Jiang 
Published: June 2021

Abstract
Gastric cancer (GC) is a heavy health burden around the world, which is the fifth most frequent tumor and leads to the third most common cancer-related deaths. It is urgent to identify prognostic markers as the guideline for personalized treatment and follow-up. We accessed the prognostic value of Early B-cell factors (EBFs) in GC. A total of 415 GC tissues and 34 normal tissues from The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD) cohort, 616 external patients from GSE15459, GSE22377, GSE51105, GSE62245 were enrolled for analysis. Univariate and multivariate Cox regression analyses were employed to evaluate the sole and integrative prognostic value of EBFs, respectively. Genetic alterations, DNA methylation of EBFs were also evaluated, as well as the involved signaling pathways. We revealed that increased EBFs associated with the poor prognosis of GC patients, the prognostic model was established in TCGA-STAD cohort, and validated in Gene Expression Omnibus (GEO) cohorts, with effectiveness in both HER2 positive and negative patients. DNA methylation was involved in the impact on prognosis. Cell cycle, immune-associated, and MAPK pathways were influenced by EBFs. Anti-CTLA4 immunotherapy is more suitable for EBFs determining high-risk groups, but not anti-PD-1/PD-L1 therapy. 5-Fluorouracil, methotrexate, vorinostat are suitable to inhibit the function of EBFs. Our new findings provide novel insight into the prediction of prognosis and clinical treatment of GC patients based on EBFs.
Incaspitolide A extracted fromCarpesium cernuuminduces apoptosisin vitrovia the PI3K/AKT pathway in benign prostatic hyperplasia
Authors: Chen Xiaoyue , Song Jingrui , Yuan Dongbo , Rao Qing , Jiang Kehua , Feng Shuhui , Zhu Guohua , Yan Chen , Li Yanmei , Zhu Jianguo 
Published: June 2021

AbstractBenign prostatic hyperplasia (BPH) is a common disease that occurs mainly in older men. The pathogenesis of BPH is complex and patients face a prolonged treatment course, and novel drugs with better selectivity and lower toxicity are required. Incaspitolide A (compound TMJ-12) is a germacrane-type sesquiterpenoid compound extracted from the plant Carpesium carnuum. Extracts of C. carnuum are known to exert suppressive effects on BPH-1 cells. In the present study, we investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G2/M phase cell cycle arrest and the apoptosis of BPH-1 cells. TMJ-12 was also shown to regulate the expression of several apoptosis- and cell cycle-related proteins, namely Bcl-2, Bax, Bad, Caspase-9, Caspase-3, cyclin-dependent kinase 1 (CDK1), Cyclin B1, CDC25C, and c-Myc, among others. Collapse of the mitochondrial membrane potential (ΔΨm) following exposure to TMJ-12 was detected with the JC-1 staining assay. Further investigation revealed that treatment with TMJ-12 inhibited the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway by increasing the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Taken together, the results suggest that TMJ-12 prevents BPH-1 cell proliferation via the PI3K/AKT pathway by inducing apoptosis and cell cycle arrest.
The Dutch Main Concept Analysis: Translation and Establishment of Normative Data
Authors: Criel Yana , Deleu Marie , De Groote Evelien , Bockstael Annelies , Kong Anthony Pak-Hin , De Letter Miet 
Published: June 2021

Purpose
The main concept analysis (MCA; Kong, 2009) quantifies the effectiveness and efficiency of information transfer during verbal discourse by means of four sets of sequential pictorial stimuli. This test was originally developed for a Cantonese-speaking population. The main goals of this study were (a) to translate and adapt the MCA to Dutch; (b) to establish normative data for healthy native Dutch-speaking adults; (c) to assess the effect of age, education level, and gender on MCA outcome; and (d) to establish inter- and intrarater reliability of the Dutch MCA.

Method
Language samples were collected from 60 healthy native Dutch speakers, equally recruited in different age (20–39 years, 40–59 years, 60–79 years) and education (middle and highly educated) categories through administration of the MCA. Utterances produced by at least 75% of the participants were included as a main concept in the Dutch MCA. Subsequently, age-specific normative data were established for each of the MCA parameters. Finally, an ICC was calculated in order to verify inter- and intrarater reliability of the Dutch MCA.

Results
The translated MCA consisted of 19 main concepts. Age-specific normative data were obtained. Both age and education level had a significant effect on MCA outcome. Information transfer in elderly was both less effectively and efficiently compared to young- and middle-aged adults. In addition, highly educated participants transferred information less efficiently compared to middle educated participants. Based on inter- and intrarater reliability measures, the Dutch MCA proved to be a reliable measuring instrument.

Conclusions
The MCA was translated to Dutch, and age-specific normative data were established for a healthy, Dutch-speaking population. The Dutch MCA is a reliable tool for eliciting and quantifying discourse production. Validation of the test for people with aphasia is necessary in order for the test to be useful in a clinical practice.
Describing Vocalizations in Young Children: A Big Data Approach Through Citizen Science Annotation
Authors: Semenzin Chiara , Hamrick Lisa , Seidl Amanda , Kelleher Bridgette L. , Cristia Alejandrina 
Published: June 2021

Purpose
Recording young children's vocalizations through wearables is a promising method to assess language development. However, accurately and rapidly annotating these files remains challenging. Online crowdsourcing with the collaboration of citizen scientists could be a feasible solution. In this article, we assess the extent to which citizen scientists' annotations align with those gathered in the lab for recordings collected from young children.

Method
Segments identified by Language ENvironment Analysis as produced by the key child were extracted from one daylong recording for each of 20 participants: 10 low-risk control children and 10 children diagnosed with Angelman syndrome, a neurogenetic syndrome characterized by severe language impairments. Speech samples were annotated by trained annotators in the laboratory as well as by citizen scientists on Zooniverse. All annotators assigned one of five labels to each sample: Canonical, Noncanonical, Crying, Laughing, and Junk. This allowed the derivation of two child-level vocalization metrics: the Linguistic Proportion and the Canonical Proportion.

Results
At the segment level, Zooniverse classifications had moderate precision and recall. More importantly, the Linguistic Proportion and the Canonical Proportion derived from Zooniverse annotations were highly correlated with those derived from laboratory annotations.

Conclusions
Annotations obtained through a citizen science platform can help us overcome challenges posed by the process of annotating daylong speech recordings. Particularly when used in composites or derived metrics, such annotations can be used to investigate early markers of language delays.
Study on the erosion characteristics of copper‐carbon electrode pairs by DC air arc
Authors: Xie Wenhan , Wu Guangning , Yang Zefeng , She Pengpeng , Wang Hong , Zuo Haozi , Wei Wenfu , Gao Guoqiang , Tu Chuanjun 
Published: June 2021

AbstractAs common electric contact materials, copper‐carbon electrode pairs are widely used in the field of electric contact such as in high‐speed railways, motor collector rings and grounding brushes. They play a key role in energy transmission in the above‐mentioned systems. Arc erosion has become a key issue threatening system safety. In this work, a dedicated arc erosion platform was built to study the polarity effect of copper‐carbon electrode pairs. It was found that arc dynamics and electrodes erosion behaviours were significantly different under different polarities, which could be understood from the mechanism of heat transfer, cooling and electron emission of the electrode. Then, when the carbon material was used as an anode, the arc caused carbon transfer: the carbon material sublimated quickly due to electron condensation and thermal conduction and quickly condensed on the low‐temperature metal electrode, while the carbon material transfer could partly inhibit the oxidation of the cathode metal electrode. In addition, the rapid sublimation of the carbon material produced high‐temperature airflow, which would make the arc impedance fluctuate and cause the arc voltage to jump. Finally, the anode heat transfer and cathode cooling mechanism directly affected the material state, and the erosion of the anode material was more serious.
Tomato leaf curl New Delhi virus (tomato New Delhi virus).
Authors: Gómez Pedro , Juárez Miguel 
Published: June 2021

Abstract

Tomato leaf curl New Delhi virus (ToLCNDV) is a bipartite, single-stranded DNA virus transmitted by the whitefly, Bemisia tabaci. The virus was first identified in India in 1995 affecting solanaceous crops (Padidam et al., 1995) and thereafter, causing major damage to cucurbit crops on the Indian subcontinent (Zaidi et al., 2017). ToLCNDV was first detected in Europe in 2012, affecting zucchini squash crops in Spain (Juárez et al., 2014), with subsequent detections in Tunisia (Mnari-Hattab et al., 2015), Italy (Panno et al., 2016) and Morocco (Sifres et al., 2018). ToLCNDV is responsible for severe outbreaks of disease in cucurbit crops in the Mediterranean basin (Juárez et al., 2019; Panno et al., 2019) and represents a serious threat to economically imp1ortant solanaceous crops in the region (Moriones et al., 2017). ToLCNDV appears to be spreading rapidly and is listed as a quarantine pest by EPPO (EPPO, 2019a). There are quarantine measures to control its whitefly vector (Bertin et al., 2018).
Puccinia buxi.
Authors:   USA, USDA-ARS
Published: June 2021

Abstract

P. buxi is an autoecious microcyclic rust, completing its life cycle with two spore forms on one host. It is native to parts of Europe and Asia. An introduction to the USA, is evidence that it can be invasive with respect to other temperate countries, particularly because its hosts in the genus Buxus are often propagated vegetatively and may carry latent infections. Boxwoods have long been popular as ornamentals, therefore the rust's current absence from North America and temperate regions of the southern hemisphere is puzzling; in the earliest introductions of the host, the pathogen would probably have been ignored or overlooked. Conditions of boxwood cultivation may discourage the rust's growth and survival.
Eigenmodes of a disordered FeCo magnonic crystal at finite temperatures
Authors: Paischer S , Buczek P A , Buczek N , Eilmsteiner D , Ernst A 
Published: June 2021

Abstract
In this report we present a systematic study of the magnonic modes in the disordered Fe0.5Co0.5 alloy based on the Heisenberg Hamiltonian using two complementary approaches. In order to account for substitutional disorder, on the one hand we directly average the transverse magnetic susceptibility in real space over different disorder configurations and on the other hand we use the coherent potential approximation (CPA). While the method of direct averaging is numerically exact, it is computationally expensive and limited by the maximal size of the supercell which can be simulated on a computer. On the contrary the CPA does not suffer from this drawback and yields a cheap numerical scheme. Therefore, we additionally compare the results of these two approaches and show that the CPA gives very good results for most of the magnetic properties considered in this report, including the magnon energies and the spatial shape of the eigenmodes. However, it turns out that while reproducing the general trend, the CPA systematically underestimates the disorder induced damping of the magnons. This provides evidence that the physics of impurity scattering in this system is governed by non-local effects missing in the CPA. Finally, we study the real space eigenmodes of the system, including their spatial shapes, and analyze their temperature dependence within the random phase approximation.
A methodology for the analysis of the three-dimensional mechanical behavior of a Nb3Sn superconducting accelerator magnet during a quench
Authors: Ferradas Troitino J , Bajas H , Bianchi L , Castaldo B , Ferracin P , Guinchard M , Izquierdo S , Lorenzo J V , Mangiarotti F , Perez J C , Takala E , Vallone G , Senatore C 
Published: June 2021

Abstract
The fast thermal and electromagnetic transients that occur in a superconducting magnet in case of a quench have the potential of generating large mechanical stresses both in the superconducting coils and in the magnet structure. While the investigation of such quench loads should generally be conducted to ensure a safe operation of the system, its importance is greatly enlarged in the case of high-field magnets based on strain sensitive superconductors. For these, a rigorous analysis of the magnet mechanics during a quench becomes critical. The scope of this work is hence to bring, for the first time, a detailed understanding of the three-dimensional mechanical behavior of a Nb3Sn accelerator magnet during a quench discharge. The study relies on the use of finite element models, where various multi-domain simulations are employed together to solve the coupled physics of the problem. Our analysis elaborates on the case study of the new MQXF quadrupole magnet, currently being developed for the high-luminosity upgrade of the LHC. Notably, we could find a very good agreement between the results of the simulation and experimental data from full-scale magnet tests. The validated model confirms the appearance of new peak stresses in the superconducting coils. An increase in the most relevant transverse coil stresses of 20–40 MPa with respect to the values after magnet cool-down has been found for the examined case.