bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpreting experience enhances the use of lexical stress and syllabic structure to predict L2 word endings
Authors: Lozano-Argüelles Cristina , Sagarra Nuria 
Published: July 2021

AbstractPrediction underlies many life’s situations including language. Monolinguals and advanced L2 learners use prosodic cues such as stress and tone in a word’s first syllable to predict the word’s suffix. To determine whether the same findings extend to words with non-morphological endings, we investigate whether Spanish monolinguals and advanced learners of Spanish with and without interpreting experience use stress (stressed, unstressed) and syllabic structure (CV, CVC) in a word’s initial syllable to predict its ending. This is crucial to understand whether associations underlying prediction are morphophonolexical associations or purely phonolexical. Interpreters were included due to their extensive experience predicting incoming speech. Participants completed an eye-tracking study where they listened to a sentence while seeing two words and selected the word they heard. Results revealed that monolinguals and interpreters predicted word endings under all conditions, but non-interpreters only predicted in the CVC oxytone condition. These findings are relevant for (1) prediction accounts, showing that phonolexical associations trigger prediction; (2) phonological models, revealing that stress and syllable information in the initial syllable are key for accessing and predicting meaning; and (3) L2 processing models, indicating that L2 learners with interpreting experience use suprasegmental information to access and predict lexical items similar to monolinguals.
Deep learning analysis based on multi-sensor fusion data for hemiplegia rehabilitation training system for stoke patients
Authors: Zhang Peng , Zhang Junxia 
Published: July 2021

AbstractBy recognizing the motion of the healthy side, the lower limb exoskeleton robot can provide therapy to the affected side of stroke patients. To improve the accuracy of motion intention recognition based on sensor data, the research based on deep learning was carried out. Eighty healthy subjects performed gait experiments under five different gait environments (flat ground, 10
${}^\circ$
upslope and downslope, and upstairs and downstairs) by simulating stroke patients. To facilitate the training and classification of the neural network, this paper presents template processing schemes to adapt to different data formats. The novel algorithm model of a hybrid network model based on convolutional neural network (CNN) and Long–short-term memory (LSTM) model is constructed. To mitigate the data-sparse problem, a spatial–temporal-embedded LSTM model (SQLSTM) combining spatial–temporal influence with the LSTM model is proposed. The proposed CNN-SQLSTM model is evaluated on a real trajectory dataset, and the results demonstrate the effectiveness of the proposed model. The proposed method will be used to guide the control strategy design of robot system for active rehabilitation training.
Management of phrenic nerve injury post-cardiac surgery in the paediatric patient
Authors: Tarmahomed Abdulla , Adan Ahmed , Thomas Ashvin , Sanghavi Ria , Amin Kiran , Asif Waleed , Pittams Ashleigh , Harky Amer 
Published: July 2021

AbstractBackground:Phrenic nerve injury is a common complication of cardiac and thoracic surgical procedures, with potentially severe effects on the health of a child. This review aims to summarise the available literature on the diagnosis and management of PNI post-cardiac surgery in paediatric patients with CHD.Main body:The presence of injury post-surgery can be difficult to detect and may present with non-specific symptoms, emphasising the importance of an effective diagnostic strategy. Chest X-ray is usually the first investigation for a suspected diagnosis of PNI, which is usually confirmed using fluoroscopy, ultrasound scan, or phrenic nerve stimulation (gold standard). Management options include supportive ventilation and/or invasive diaphragmatic plication surgery. While the optimal timing of plication surgery remains controversial, it is now the most widely accepted treatment for PNI in children post-CHD surgery, especially for very young patients who cannot be weaned off supportive ventilation. Further research is needed to determine the optimal timing of surgical intervention for positive outcomes and to explore the benefits of using minimally invasive surgical techniques in children.Conclusion:PNI is a common and serious complication of CHD surgery, therefore, its diagnosis and management in the paediatric population are of major importance. Further research is needed to determine the optimal timing of surgical intervention for positive outcomes and to explore the benefits of using minimally invasive surgical techniques in children.
Effect of planting time and row spacing on growth and seed production of junglerice (Echinochloa colona) and feather fingergrass (Chloris virgata) in sorghum
Authors: Squires Caleb , Mahajan Gulshan , Walsh Michael , Chauhan Bhagirath S. 
Published: July 2021

AbstractJunglerice and feather fingergrass are major problematic weeds in the summer sorghum cropping areas of Australia. This study aimed to investigate the growth and seed production of junglerice and feather fingergrass in crop-free (fallow) conditions and under competition with sorghum planted in 50-cm and 100-cm row spacings at three sorghum planting and weed emergence timings. Results revealed that junglerice and feather fingergrass had greater biomass in early planting (November 11) compared to late planting times (January 11). Under fallow conditions, seed production of junglerice ranged from 12,380 to 20,280 seeds plant–1, with the highest seed production for the December 11 and lowest for the January 11 planting. Seed production of feather fingergrass under fallow conditions ranged from 90,030 to 143,180 seeds plant–1. Seed production of feather fingergrass under crop-free (fallow) conditions was similar for November 11 and December 11 planting times, but higher for the January 11 planting. Sorghum crop competition at both row spacings reduced the seed production of junglerice and feather fingergrass >75% compared to non-crop fallow. Narrow row spacing (50 cm) in early and mid-planted sorghum (November 11 and December 11) reduced the biomass of junglerice to a greater extent (88% to 92% over fallow-grown plants) compared to wider row spacing (100 cm). Narrow row spacing was found superior in reducing biomass of feather fingergrass compared to wider row spacing. Our results demonstrate that sorghum crops can substantially reduce biomass and seed production of junglerice and feather fingergrass through crop competition compared with growth in fallow conditions. Narrow row spacing (50 cm) was found superior to wider row spacing (100 cm) in terms of weed suppression. These results suggest that narrow row spacing and late planting time of sorghum crops can strengthen an integrated weed management program against these weeds by reducing weed growth and seed production.
Large-scale evaluation of 2,4-D choline off-target movement and injury in 2,4-D-susceptible soybean
Authors: Werle Rodrigo , Mobli Ahmadreza , Striegel Sarah , Arneson Nicholas , DeWerff Ryan , Brown Ashli , Oliveira Maxwel 
Published: July 2021

AbstractEnlist E3TM soybean cultivars permit over-the-top application of labeled glyphosate, glufosinate, and 2,4-D choline products. Increased Enlist E3TM trait adoption and use of 2,4-D choline postemergence across U.S. soybean production systems raise concerns regarding potential for 2,4-D off-target movement (OTM). A large-scale drift experiment was established near Sun Prairie, WI, and Arlington, WI, in 2019 and 2020, respectively. A 2,4-D-resistant soybean cultivar was planted in the center of the field (∼3 ha), while the surrounding area was planted with a 2,4-D-susceptible cultivar. An application of 785 ae ha−1 2,4-D choline plus 834 g ae ha−1 glyphosate was completed within the center block at R2 and V6 growth stages on August 1, 2019, and July 3, 2020, respectively. Filter papers were placed in-swath and outside of the treated area in one upwind transect and three downwind transects to estimate particle deposition. Low-volume air samplers ran for the 0.5-h to 48-h period following application to estimate 2,4-D air concentration. Injury to 2,4-D-susceptible soybean was assessed 21 d after treatment (0% to 100% injury). The 2,4-D deposition in-swath was 9,966 and 5,727 ng cm−2 in 2019 and 2020, respectively. Three-parameter log-logistic models estimated the distance to 90% reduction in 2,4-D deposition (D90) to be 0.63 m and 0.90 m in 2019 and 2020, respectively. In 2020, the 2,4-D air concentration detected was lower for the upwind (0.395 ng m−3) than the downwind direction (1.34 ng m−3), although both were lower than the amount detected in-swath (4.01 ng m−3). No soybean injury was observed in the downwind or upwind directions. Our results suggest that 2,4-D choline applications following label recommendations pose little risk to 2,4-D-susceptible soybean cultivars; however, further work is needed to understand 2,4-D choline OTM under different environmental conditions and the presence of other susceptible crops.
Investigating the Propagation From Meteorological to Hydrological Drought by Introducing the Nonlinear Dependence With Directed Information Transfer Index
Authors: Zhou Zhaoqiang , Shi Haiyun , Fu Qiang , Ding Yibo , Li Tianxiao , Liu Suning 
Published: July 2021

AbstractMeteorological drought is the fuse of hydrological drought, and understanding the propagation mechanisms from meteorological to hydrological drought is of great significance to the monitoring and prevention of hydrological drought. Besides the linear dependence, this study thoroughly investigated the propagation from meteorological to hydrological drought by introducing the nonlinear dependence with directed information transfer index (DITI) for the first time. In this study, the standardized precipitation index and the standardized runoff index were used to represent meteorological drought and hydrological drought, respectively. A new drought response time (DRT) evaluation system was constructed based on the maximum Pearson correlation coefficient and DITI, simultaneously considering the linear and nonlinear relationships between meteorological drought and hydrological drought. Moreover, the relationships of drought characteristics (duration and severity) between these two types of drought were established by using run theory and mathematical function, and the trigger thresholds from meteorological to hydrological drought were then determined. The results indicate that: (a) the effective drought propagation rate was mainly affected by the characteristics of meteorological drought events and the sensitivity of hydrological drought to meteorological drought; (b) the DRT in the Pearl River Basin (PRB) was mainly concentrated in 2–5 months, and the drought translation rate in the PRB was relatively large; and (c) the duration of hydrological drought events was longer in the sub‐regions with smaller meteorological drought trigger thresholds.
Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine
Authors: Cools Roshan , Arnsten Amy F. T. 
Published: July 2021

AbstractThe primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and yet is tremendously dependent on a precise neurochemical environment for proper functioning. Depletion of noradrenaline and dopamine, or of acetylcholine from the dorsolateral PFC (dlPFC), is as devastating as removing the cortex itself, and serotonergic influences are also critical to proper functioning of the orbital and medial PFC. Most neuromodulators have a narrow inverted U dose response, which coordinates arousal state with cognitive state, and contributes to cognitive deficits with fatigue or uncontrollable stress. Studies in monkeys have revealed the molecular signaling mechanisms that govern the generation and modulation of mental representations by the dlPFC, allowing dynamic regulation of network strength, a process that requires tight regulation to prevent toxic actions, e.g., as occurs with advanced age. Brain imaging studies in humans have observed drug and genotype influences on a range of cognitive tasks and on PFC circuit functional connectivity, e.g., showing that catecholamines stabilize representations in a baseline-dependent manner. Research in monkeys has already led to new treatments for cognitive disorders in humans, encouraging future research in this important field.
SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression
Authors: Zhang Yali , Ma Yanni , Wu Guixian , Xie Mingling , Luo Chengxin , Huang Xiangtao , Tian Feng , Chen Jieping , Li Xi 
Published: July 2021

AbstractMantle cell lymphoma (MCL) is highly aggressive and its treatment remains challenging, understanding its pathogenesis is critical for future targeted therapy. SUMO specific proteases 1 (SENP1) is an important protein that regulates the balance between SUMOylation and deSUMOylation. We found that SENP1 was upregulated in MCL patient samples and cell lines. Knockdown of SENP1 could inhibit the proliferation and promote the apoptosis of MCL cells. We also found that SENP1 knockdown caused inhibition of the JAK-STAT5 pathway and upregulation of tumor suppressor cytokine signaling 2 (SOCS2). Moreover, MCL tumor growth in vivo was significantly suppressed after SENP1 knockdown in a xenograft nude mouse model. In summary, our results showed that SENP1 is involved in the pathogenesis of MCL and may be a potential therapeutic target.
Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development
Authors: Han Bitnara , Jung Byung-Kwon , Park So-Hyun , Song Kyu Jin , Anwar Muhammad Ayaz , Ryu Kwon-Yul , Kim Kwang Pyo 
Published: July 2021

AbstractTestis development, including early embryonic gonad formation and late postnatal spermatogenesis, is essential for the reproduction of higher metazoans to generate fertile gametes, called sperm. We have previously reported that the polyubiquitin gene Ubb is required for fertility in both male and female mice. In particular, the Ubb-null male mice showed an azoospermia phenotype due to arrest of spermatogenesis at the pachytene stage. Here, we analyzed the whole testis proteome at postnatal day 20 to define the molecular mediators of the male-infertility phenotype caused by Ubb knockout. From the identified proteome, 564 proteins were significantly and differentially expressed in Ubb-knockout testes and, among these, 36 downregulated proteins were involved at different stages of spermatogenesis. We also found that levels of piRNA metabolic process-related proteins, including Piwil2 and Tdrd1, were downregulated in Ubb-null testes through functional gene ontology analysis. Further, protein–protein interaction mapping revealed that 24 testis development-related proteins, including Hsp90aa1, Eef1a1, and Pabpc1, were directly influenced by the depletion of ubiquitin. In addition, the reduced mRNA levels of these proteins were observed in Ubb-knockout testes, which closely resembled the global downregulation of piRNA-metabolic gene expression at the transcriptional and post-transcriptional levels. Together with proteomic and transcriptional analyses, our data suggest that Ubb expression is essential for the maintenance of testicular RNA-binding regulators and piRNA-metabolic proteins to complete spermatogenesis in mice.
Evaluation of multiple transcriptomic gene risk signatures in male breast cancer
Authors: Bayani Jane , Poncet Coralie , Crozier Cheryl , Neven Anouk , Piper Tammy , Cunningham Carrie , Sobol Monika , Aebi Stefan , Benstead Kim , Bogler Oliver , Dal Lago Lissandra , Fraser Judith , Hilbers Florentine , Hedenfalk Ingrid , Korde Larissa , Linderholm Barbro , Martens John , Middleton Lavinia , Murray Melissa , Kelly Catherine , Nilsson Cecilia , Nowaczyk Monika , Peeters Stephanie , Peric Aleksandra , Porter Peggy , Schröder Carolien , Rubio Isabel T. , Ruddy Kathryn J. , van Asperen Christi , Van Den Weyngaert Danielle , van Deurzen Carolien , van Leeuwen-Stok Elise , Vermeij Joanna , Winer Eric , Giordano Sharon H. , Cardoso Fatima , Bartlett John M. S. 
Published: July 2021

AbstractMale breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Several multigene assays are increasingly used to guide clinical treatment decisions in female BCa, however, there are limited data on the utility of these tests in male BCa. Here we present the gene expression results of 381 M0, ER+ve, HER2-ve male BCa patients enrolled in the Part 1 (retrospective analysis) of the International Male Breast Cancer Program. Using a custom NanoString™ panel comprised of the genes from the commercial risk tests Prosigna®, OncotypeDX®, and MammaPrint®, risk scores and intrinsic subtyping data were generated to recapitulate the commercial tests as described by us previously. We also examined the prognostic value of other risk scores such as the Genomic Grade Index (GGI), IHC4-mRNA and our prognostic 95-gene signature. In this sample set of male BCa, we demonstrated prognostic utility on univariate analysis. Across all signatures, patients whose samples were identified as low-risk experienced better outcomes than intermediate-risk, with those classed as high risk experiencing the poorest outcomes. As seen with female BCa, the concordance between tests was poor, with C-index values ranging from 40.3% to 78.2% and Kappa values ranging from 0.17 to 0.58. To our knowledge, this is the largest study of male breast cancers assayed to generate risk scores of the current commercial and academic risk tests demonstrating comparable clinical utility to female BCa.
Tunable dynamical magnetoelectric effect in antiferromagnetic topological insulator MnBi2Te4 films
Authors: Zhu Tongshuai , Wang Huaiqiang , Zhang Haijun , Xing Dingyu 
Published: July 2021

AbstractAxion was postulated as an elementary particle to solve the strong charge conjugation and parity puzzle, and later axion was also considered to be a possible component of dark matter in the universe. However, the existence of axions in nature has not been confirmed. Interestingly, axions arise out of pseudoscalar fields derived from the Chern–Simons theory in condensed matter physics. In antiferromagnetic insulators, the axion field can become dynamical due to spin-wave excitations and exhibits rich exotic phenomena, such as axion polariton. However, antiferromagnetic dynamical axion insulator has yet been experimentally identified in realistic materials. Very recently, MnBi2Te4 was discovered to be an antiferromagnetic topological insulator with a quantized static axion field protected by inversion symmetry $${\mathcal{P}}$$
P
and magnetic-crystalline symmetry $${\mathcal{S}}$$
S
. Here, we studied MnBi2Te4 films in which both the $${\mathcal{P}}$$
P
and $${\mathcal{S}}$$
S
symmetries are spontaneously broken and found that substantially enhanced dynamical magnetoelectric effects could be realized through tuning the thickness of MnBi2Te4 films, temperature, or element substitutions. Our results show that thin films of MnBi2Te4 and related compounds could provide a promising material platform to experimentally study axion electrodynamics.
Stability and equation of state of face-centered cubic and hexagonal close packed phases of argon under pressure
Authors: Dewaele Agnès , Rosa Angelika D. , Guignot Nicolas , Andrault Denis , Rodrigues João Elias F. S. , Garbarino Gaston 
Published: July 2021

AbstractThe compression of argon is measured between 10 K and 296 K up to 20 GPa and and up to 114 GPa at 296 K in diamond anvil cells. Three samples conditioning are used: (1) single crystal sample directly compressed between the anvils, (2) powder sample directly compressed between the anvils, (3) single crystal sample compressed in a pressure medium. A partial transformation of the face-centered cubic (fcc) phase to a hexagonal close-packed (hcp) structure is observed above 4.2–13 GPa. Hcp phase forms through stacking faults in fcc-Ar and its amount depends on pressurizing conditions and starting fcc-Ar microstructure. The quasi-hydrostatic equation of state of the fcc phase is well described by a quasi-harmonic Mie–Grüneisen–Debye formalism, with the following 0 K parameters for Rydberg-Vinet equation:$$V_0$$V0= 38.0 Å$$^3$$3/at,$$K_0$$K0= 2.65 GPa,$$K'_0$$K0′= 7.423. Under the current experimental conditions, non-hydrostaticity affects measuredP–Vpoints mostly at moderate pressure ($$\le$$≤20 GPa).
Cat-CrNP as new material with catalytic properties for 2-chloro-2-propen-1-ol and ethylene oligomerizations
Authors: Malinowski Jacek , Jacewicz Dagmara , Sikorski Artur , Urbaniak Mariusz , Rybiński Przemysław , Parnicka Patrycja , Zaleska-Medynska Adriana , Gawdzik Barbara , Drzeżdżon Joanna 
Published: July 2021

AbstractThe contemporary search for new catalysts for olefin oligomerization and polymerization is based on the study of coordinating compounds and/or organometallic compounds as post-metallocene catalysts. However known catalysts are suffered by many flaws, among others unsatisfactory activity, requirement of high pressure or instability at high temperatures. In this paper, we present a new catalyst i.e. the crystalline complex compound possesing high catalytic activity in the oligomerization of olefins, such as 2-chloro-2-propen-1-ol and ethylene under very mild conditions (room temperature, 0.12 bar for ethylene oligomerization, atmospheric pressure for 2-chloro-2-propen-1-ol oligomerization). New material—Cat-CrNP ([nitrilotriacetato-1,10-phenanthroline]chromium(III) tetrahydrate) has been obtained as crystalline form of the nitrilotriacetate complex compound of chromium(III) with 1,10-phenanthroline and characterized in terms of its crystal structure by the XRD method and by multi-analytical investigations towards its physicochemical propeties The yield of catalytic oligomerization over Cat-CrNP reached to 213.92 g · mmol−1· h−1· bar−1and 3232 g · mmol−1· h−1· bar−1for the 2-chloro-2-propen-1-ol and ethylene, respectively. Furthemore, the synthesis of Cat-CrNP is cheap, easy to perform and solvents used during preparation are environmentally friendly.