bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conocimientos y actitudes hacia la donación voluntaria de sangre en estudiantes de una universidad pública de Lima-Perú
Authors: Cuba Sancho Juana Matilde , Paredes García Verónica Amparo , Merino Lozano Alicia Lourdes 
Published: July 2021

Objetivo: Determinar los conocimientos y actitudes hacia la donación voluntaria de sangre que tienen los estudiantes de Enfermería y Medicina de una universidad pública, 2018. Material y Métodos: investigación aplicada, con enfoque cuantitativo, descriptivo-comparativo, transversal. La muestra estuvo conformada por 59 estudiantes de Enfermería y 64 estudiantes de Medicina. Se empleó como técnica la encuesta y como instrumentos un cuestionario para conocimientos y una escala tipo Likert modificada para actitudes, previo consentimiento informado. Resultados: El 86% de los estudiantes de Enfermería y el 88% de Medicina tienen conocimientos acerca de la donación voluntaria de sangre; el 63% de estudiantes de Enfermería y el 59% de medicina no conocen los requisitos para donar sangre como la edad, el peso, intervalo de donación, entre otros; el 70-69% de estudiantes de ambas facultades conoce el procedimiento que se realiza como la cantidad de sangre que se debe donar, contraindicaciones, la importancia, lugares de donación; referente a la actitud que presentan hacia la donación de sangre el 65% de estudiantes de medicina y el 56% de enfermería manifiestan una actitud de aceptación mientras que el 27% y 42% de estudiantes de medicina y enfermería mostraron una actitud de indiferencia constituyéndose en un nudo crítico, que debe ser abordado por los profesionales de la salud diseñando estrategias que permitan generar una cultura de la donación en la población en general. Conclusiones: La mayoría de los estudiantes de enfermería y medicina tienen conocimientos sobre la donación de sangre y el procedimiento que se aplica, sin embargo, la mayoría desconoce los requisitos que se necesita para donar; respecto a la actitud la mayoría de los estudiantes muestran aceptación, y otro grupo minoritario indiferencia.
Análisis del Gasto del Bolsillo en el Servicio Dental de los Afiliados al SIS de Lima Metropolitana según Enaho, 2018
Authors: Diaz-Mujica Juana Yris , Panduro Tello Maycol Alan orlando 
Published: July 2021

Objetivos: Estimar gasto de bolsillo en el servicio dental de los afiliados al SIS de Lima Metropolitana según Enaho 2018. Materiales y métodos: Estudio cuantitativo, descriptivo, de diseño no experimental, transversal y retrospectivo. La técnica fue la recolección de datos mediante la ficha de registro tomando datos secundarios de la “Encuesta Nacional de Hogares sobre Condiciones de Vivienda y Pobreza, Enaho, 2018”, la muestra fue de 14,874 personas que han sido atendidas en el servicio dental en el año 2018. Resultados: A intervalos de 9,705059 y 19,95492 como limites inferior y superior a una desviación estándar de 2,610325 el gasto de bolsilo fue de 14,82999; en relación al gasto por sexo en promedio, el de la mujer fue de 19,46143 y del varon 9,914876; el gasto segun edad indica que el grupo de 65 a 69 años gasta en promedio 40,03425 soles; el gasto por nivel educativo indica que los que tienen nivel inicial gastan 40,24546; y en cuanto a nivel de pobreza, los pobres extremos presentan gastos de 0,000 mientras que el pobre no extremo 2,850577. Conclusiones: Se concluyo que el gasto del bolsillo de afiliados al SIS por servicios dentales es de 14,80 soles en promedio, en Lima Metropolitana
Fatores possíveis de promover ou comprometer a motivação de estudantes de ciências contábeis: análise em uma instituição de ensino de Minas Gerais
Authors: Da Silva Costa Breno , Gonçalves de Faria Janaina , Camargos Avelino Bruna , Vianna Brugni Talles 
Published: July 2021

Objetivo: O objetivo desta pesquisa é avaliar os fatores que influenciam a motivação de estudantes do curso de Ciências Contábeis de uma Instituição de Ensino Superior localizada em Minas Gerais, à luz da Teoria da Autodeterminação.
Metodologia: Para avaliar a motivação dos discentes, 70 estudantes do primeiro ano do curso de Ciências Contábeis e 100 alunos matriculados no 8º, 9° e 10° períodos da graduação em análise, ou seja, na fase final do curso, compuseram a amostra deste estudo mediante o preenchimento de um questionário contendo a versão brasileira da Escala de Motivação Acadêmica (EMA), composta por 29 questões.
Resultados: Foi possível inferir, por meio das médias encontradas para os fatores, que os discentes da fase inicial do curso estão mais autodeterminados e intrinsecamente motivados do que desmotivados com o percurso acadêmico. Em relação à motivação dos respondentes do final da graduação, se comparada à motivação de indivíduos matriculados na fase inicial do curso, constatou-se que a maioria deles encontra-se mais desmotivado no final da graduação.
Contribuições do Estudo: Tendo em vista os resultados encontrados, cabe à coordenação do curso, juntamente com os professores, refletirem quanto à adequação curricular, visando atender os anseios dos estudantes. Da mesma forma, compete aos professores o aperfeiçoamento da didática e metodologia de ensino, com vistas a suprir as necessidades dos discentes, assim como propiciar um ambiente favorável ao aprendizado. Acredita-se que essas são algumas medidas que irão contribuir para aumentar o nível de motivação dos alunos do curso de Ciências Contábeis e, consequentemente, melhorar o grau de satisfação destes indivíduos com relação à graduação oferecida pela IES em análise
Sentimentos de culpa vivenciados na pós-graduação
Authors: Biernaski Kachenski Ricardo , da Silva Sousa Rayane Camila , Zepeda Toro Pavel Elias , Costa Flaviano , Colauto Romualdo Douglas 
Published: July 2021

Objetivo: A pesquisa consiste em verificar o nível de concordância dos estudantes quanto aos sentimentos de culpa vivenciados na pós-graduação stricto sensu.
Metodologia: O estudo é de caráter descritivo com abordagem quantitativa. A coleta dos dados foi realizada por meio de survey e o instrumento de coleta de dados foi a Escala Multidimensional da Culpabilidade de Aquino e Medeiros (2009). Para análise dos dados utiliza-se Análise Fatorial Exploratória e o teste Kruskal-Wallis (KW) para verificar as diferenças entre os grupos.
Resultados: Os resultados evidenciaram que há diferenças de distribuição do sentimento Culpa Temporal, Culpa Subjetiva e Culpa Objetiva. A maioria dos respondentes concordou totalmente com os sentimentos de culpa descritos no Fator Culpa Temporal. A pós-graduação stricto sensu tem uma alta demanda de estudos, pesquisas e atividades extras que ocupam boa parte do tempo dos estudantes, assim o aspecto temporal acaba sendo uma de suas principais preocupações, desencadeando o sentimento de culpa.
Contribuições do Estudo: O estudo ajuda a compreender se os estudantes se sentem culpados por diversas situações corriqueiras na vida das pessoas e, futuramente, pode-se analisar se o nível de sentimento de culpa interfere no desempenho acadêmico; se desenvolve atitudes tóxicas no relacionamento interpessoal entre outros fatores comportamentais.
Formação didático-pedagógica dos egressos da pós-graduação stricto sensu em ciências contábeis de uma instituição federal de ensino superior
Authors: Fernandes Thayná de Oliveira , Dos Santos Araújo Valdineide , Nóbrega Cavalcanti Paulo Roberto 
Published: July 2021

Objetivo: O presente estudo objetivou investigar a formação didático-pedagógica no curso de pós-graduação em Ciências Contábeis de uma Instituição Federal de Ensino Superior.
Metodologia: Buscou-se os alunos egressos da pós-graduação (stricto sensu) atual na Instituição Federal de Ensino Superior (IES) em estudo e do Programa Multiinstitucional e Inter-Regional de Pós- Graduação em Ciências Contábeis que permaneceu antes da criação do atual programa de pós-graduação da IES, chegando ao número de 65 (Sessenta e cinco) egressos até março de 2018, dos quais 42 (quarenta e dois) retornaram o questionário respondido. Quanto aos objetivos, trata-se de uma pesquisa descritiva e quanto à abordagem do problema, tem caráter qualitativo. Ademais, no plano metodológico, a opção pela abordagem foi a pesquisa documental e de campo.
Resultados: Os resultados foram analisados através da análise de conteúdo conforme Bardin (2011) e estatística descritiva. Estes apresentam-se quanto ao perfil dos egressos, sua reflexão da atuação como docente, tendo sido observado uma lacuna em competências de metodologia de ensino e didático-pedagógicas na formação dos egressos. Quanto à análise documental, verificou-se que as disciplinas que objetivam assuntos de formação didático-pedagógica são tratadas como eletivas. Além disso, os egressos percebem que houve uma formação acadêmica de excelência, com um bom aprofundamento de conhecimentos específicos das diversas áreas não exploradas na graduação e com contribuição na construção de conhecimento na área de estudo. Ante esse cenário, a formação é contínua, sendo necessária durante toda a prática docente, pois o aprender é constante e essencial nessa profissão.
Contribuições do Estudo: A pesquisa contribui para analisar a formação acadêmica recebida pelos egressos da Pós-graduação stricto sensu em Ciências Contábeis e para refletir sobre a formação docente recebida pelos dos sujeitos da pesquisa.
The effect of the introduction of market makers on stock liquidity: evidence from the Brazilian stock market
Authors: Carvalho Gabriel Augusto de , Ribeiro João Eduardo , Correia Laíse Ferraz 
Published: July 2021

Purpose: This study aimed to analyze whether the introduction of market makers as specialized intermediaries in the trading of stocks listed on the Brazilian stock exchange is a useful procedure for increasing the market liquidity of these assets.
Methodology: The Chow structural break test was performed in the time series of the liquidity proxies, average spread, turnover ratio, and financial volume on a sample of 55 stocks. We chose to consider data in the window of 260 days before and after the start of the market maker's activity, because it represents the approximate number of trading sessions in a year, and to avoid erroneous conclusions due to the volatility of the Brazilian stock market.
Results: The results showed with a 99% confidence level that after the introduction of market makers, (i) 67% of the stocks analyzed had abrupt and statistically significant changes in the average spread; (ii) 47% in the turnover ratio; and (iii) 60% had changes in the volume transactions. At the confidence level of 95%, (i) 76% of the stocks analyzed showed abrupt changes in the average spread; (ii) 65% had changes in turnover; (iii) and 69% had changes in the trading volume. Using a lower confidence level of 90%, the results revealed 85% of the stocks had abrupt and statistically significant changes in the average spread, 78% in the turnover ratio, and 73% in the trading volume.
Contributions of the Study: This paper provides strong evidence on the performance of market makers and the influence they have on the market liquidity of stocks traded on the Brazilian stock exchange. We found that contracting market makers increase market liquidity and contribute significantly to the assets’ transactions.
Antiprotozoal and Anthelmintic Activity of Zinc Oxide Nanoparticles
Authors: do Carmo Neto José Rodrigues , Guerra Rhanoica Oliveira , Machado Juliana Reis , Silva Anielle Christine Almeida , da Silva Marcos Vinicius 
Published: July 2021

:
Nanomaterials represent a wide alternative for the treatment of several diseases that
affect both human and animal health. The use of these materials consists, mainly, in trying to
solve the problem of resistance that pathogenic organisms acquire to conventional drugs. A
well-studied example that represents a potential component for biomedical applications is the
use of zinc oxide (ZnO) nanoparticles (NPs). Its antimicrobial function is related, especially to
the ability to generate/induce ROS that affects the homeostasis of the pathogen in question.
Protozoa and helminths that harm human health and the economic performance of animals
have already been exposed to this type of nanoparticle. Thus, through this review, our goal is
to discuss the state-of-the-art effect of ZnONPs on these parasites.
The Screening of Phytochemicals Against NS5 Polymerase to Treat Zika
Virus Infection: Integrated Computational Based Approach
Authors: Rehman Abdur , Ashfaq Usman Ali , Javed Muhammad Rizwan , Shahid Farah , Noor Fatima , Aslam Sidra 
Published: July 2021

Background:
The recent Zika Virus (ZIKV) outbreak provides a spur for new, efficient,
and safe anti-Zika Virus agents. RNA-dependent RNA polymerase (RdRp) is critical amongst the
seven non-structural proteins for viral replication and considered an attractive drug target.

Methods:
In this study, molecular docking approach was used to rationally screen the library of
5000 phytochemicals to find inhibitors against NS5 RdRp. LigX tool was used to analyze the 2D
plots of receptor-ligand interactions. The top-ranked compounds were then subjected to in-silico
pharmacokinetic study.

Results:
The compounds namely Polydatin, Dihydrogenistin, Liquiritin, Rhapontin and Cichoriin
were successfully bound inside the pocket of NS5 RdRp. Polydatin was the leading phytochemical
that showed high docking score -18.71 (kcal/mol) and bonding interaction at the active-site of NS5
RdRp. They were subjected to analyze drug-like properties that further reinforced their validation
and showed that they have more capability to attach with the receptor as compared to
SOFOSBUVIR control drug. MD simulation of the top two complexes was performed and the
simulated complexes showed stability and ligands were kept within the bonding pocket.

Conclusion:
The study might facilitate the development of a natural and cost-effective drug
against ZIKV. Further validation, however, is necessary to confirm its effectiveness and its
biocompatibility.
Biocatalytic Synthesis of Terpene Esters and their Biological Activity in
Human Glioma Cells
Authors: Kutyła Mateusz , Maciejczyk Aleksandra , Trytek Mariusz , Jakubowicz-Gil Joanna 
Published: July 2021

Background:
Gliomas are highly malignant brain tumours with high resistance to
chemotherapy. Therefore, investigations of new therapeutic molecules with high anti-glioma activity
are of great importance.

Objective:
In this work, biocatalytic esterification of terpene alcohols with proven anti-cancer activity
was performed to enhance their potency to induce cell death in human glioblastoma multiforme
T98G and anaplastic astrocytoma MOGGCCM cell lines in vitro.

Method and Results:
We used primary terpene alcohols and carboxylic acids with a length of
two to nine carbon atoms. The structure of the alcohols had an influence on the esterification efficiency,
which decreased in the following order: monocyclic > linear > bicyclic. Terpene alcohols
and their esters only induced apoptotic cell death, which is highly desirable from a therapeutic
point of view, but did not induce autophagy and necrosis. The esterification of perillyl alcohol
with butyric acid caused a 4-fold increase in cell death induction in the T98G line. Citronellol valerate,
caprylate, and pelargonate and myrtenol butyrate, caprylate and pelargonate also showed
higher activity than their alcohol precursors.

Conclusion:
We have herein shown that esterification of natural alcohols by biocatalysis can be used
for improving the activity of other compounds investigated for their anti-glioma activity.
Recent Patent-Based Perspective on Diagnostic and Therapeutic Interventions in Malignant Mesothelioma: Is Drug Repositioning Knocking on the Door?
Authors: Yadav Vikas , Safari Roghaiyeh 
Published: July 2021

Background:
Malignant Mesothelioma (MM), an orphan but aggressive malignancy of
the mesothelial membrane, is a fatal tumour. Global epidemic related to malignant pleural mesothelioma
is on the rise, so there is a need to explore novel biomarkers and ingenious therapeutic approaches
to stalk this silent killer.

Objective:
The main aim of the present review is to provide a consolidated overview of the recent active patents related to diagnosis and therapy in MM that will affect its future management.

Methods:
A search of existing literature was conducted from a PubMed database search. Recent patent
information was fetched out from online free open-access databases. For related clinical trials,
www.clinicaltrial.gov was searched.

Results:
Patent search data showed 72 active patents related to diagnosis and therapy in the field of
MM, which we classified into eight broad categories. Of these, maximum 17 patents were attributed
to immunotherapy and 13 were attributed to “Drug Repositioning” and “Biological / synthetic”
based candidates. Relatively low number of patents accounts for gene signature (7), epigenetics (3)
and microRNA (2) based diagnosis and therapy. Remaining 17 patents were distributed amongst virotherapy
and various miscellaneous categories. Furthermore, our clinical trial based investigation
revealed the futuristic impact of listed patents in MM patient management.

Conclusion:
This review article has provided an overview of patent based advancement in the field
of MM, which might become apex in the clinical settings in future. Interestingly, immunotherapy
and “drug repositioning” based therapy seems to be the front-runners in the race to provide relief.
In-hospital Mortality and the Predictive Ability of the Modified Early Warning Score in Ghana: Single-Center, Retrospective Study
Authors: Abbey Enoch Joseph , Mammen Jennifer S R , Soghoian Samara E , Cadorette Maureen A F , Ariyo Promise 
Published: July 2021

Background
The modified early warning score (MEWS) is an objective measure of illness severity that promotes early recognition of clinical deterioration in critically ill patients. Its primary use is to facilitate faster intervention or increase the level of care. Despite its adoption in some African countries, MEWS is not standard of care in Ghana. In order to facilitate the use of such a tool, we assessed whether MEWS, or a combination of the more limited data that are routinely collected in current clinical practice, can be used predict to mortality among critically ill inpatients at the Korle-Bu Teaching Hospital in Accra, Ghana.

Objective
The aim of this study was to identify the predictive ability of MEWS for medical inpatients at risk of mortality and its comparability to a measure combining routinely measured physiologic parameters (limited MEWS [LMEWS]).

Methods
We conducted a retrospective study of medical inpatients, aged ≥13 years and admitted to the Korle-Bu Teaching Hospital from January 2017 to March 2019. Routine vital signs at 48 hours post admission were coded to obtain LMEWS values. The level of consciousness was imputed from medical records and combined with LMEWS to obtain the full MEWS value. A predictive model comparing mortality among patients with a significant MEWS value or LMEWS ≥4 versus a nonsignificant MEWS value or LMEWS <4 was designed using multiple logistic regression and internally validated for predictive accuracy, using the receiver operating characteristic (ROC) curve.

Results
A total of 112 patients were included in the study. The adjusted odds of death comparing patients with a significant MEWS to patients with a nonsignificant MEWS was 6.33 (95% CI 1.96-20.48). Similarly, the adjusted odds of death comparing patients with a significant versus nonsignificant LMEWS value was 8.22 (95% CI 2.45-27.56). The ROC curve for each analysis had a C-statistic of 0.83 and 0.84, respectively.

Conclusions
LMEWS is a good predictor of mortality and comparable to MEWS. Adoption of LMEWS can be implemented now using currently available data to identify medical inpatients at risk of death in order to improve care.
Virtual Reality Tour to Reduce Perioperative Anxiety in an Operating Setting Before Anesthesia: Randomized Clinical Trial
Authors: Vogt Lina , Klasen Martin , Rossaint Rolf , Goeretz Ute , Ebus Peter , Sopka Sasa 
Published: July 2021

Background
Perioperative anxiety is a major burden to patients undergoing surgeries with general anesthesia.

Objective
This study investigated whether a virtual operating room tour (VORT) before surgery can be used to ameliorate perioperative anxiety.

Methods
We employed a randomized parallel-group design with 2 study arms to compare VORT to the standard operation preparation procedure. The study included 84 patients. A validated inventory (state-trait operation anxiety-state) was used to assess perioperative state anxiety before (T1) and after (T2) surgery. In addition, trait operation anxiety was evaluated with an additional validated inventory (state-trait operation anxiety-trait). Moreover, user ratings on the usefulness of VORT were assessed with an evaluation questionnaire. Study arms were compared for perioperative state anxiety with two-tailed independent samples t tests. Subjective ratings were correlated with STOA-Trait values to investigate possible associations between perioperative anxiety with perceived usefulness.

Results
There were no significant differences in perioperative state anxiety between VORT and standard operation preparation procedures before and after the surgery. Nonetheless, patients’ ratings of VORT overall were positive. The tour was perceived as useful and, therefore, showed acceptance for VR use. These ratings were unrelated to the degree of perioperative anxiety.

Conclusions
The subjective benefit of VORT could not be explained by a reduction of perioperative anxiety. Instead, VORT appears to serve the need for information and reduce uncertainty. In addition, VORT is perceived as beneficial regardless of the age of the patients. Considering this effect and the manageable organizational and financial effort toward implementation, the general use of VORT can be recommended.

Trial Registration
ClinicalTrials.gov NCT04579354; https://clinicaltrials.gov/ct2/show/NCT04579354