bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes in 1096 patients with severe thrombotic thrombocytopenic purpura before the Caplacizumab era
Authors: Van de Louw Andry , Mariotte Eric , Darmon Michael , Cohrs Austin , Leslie Douglas , Azoulay Elie 
Published: August 2021

Introduction
Thrombotic thrombocytopenic purpura (TTP) is a diagnostic and therapeutic emergency. Therapeutic plasma exchange (TPE) combined with immunosuppression has been the cornerstone of the initial management. To produce optimal benefits, emerging treatments must be used against a background of best standard of care. Clarifying current uncertainties is therefore crucial.

Methods
The objective of this study was to analyze a large high-quality database (Marketscan) of TTP patients managed between 2005 and 2014, in the pre-caplacizumab era, in order to assess the impact of time to first TPE and use of first-line rituximab on mortality, and whether mortality declines over time.

Results
Among the 1096 included patients (median age 46 [IQR 35–55], 70% female), 28.8% received TPE before day 2 in the ICU. Hospital mortality was 7.6% (83 deaths). Mortality was independently associated with older age (hazard ratio [HR], 1.024/year; 95% confidence interval [95%CI], [1.009–1.040]), diagnosis of sepsis (HR, 2.360; 95%CI [1.552–3.588]), and the need for mechanical ventilation (HR, 4.103; 95%CI, [2.749–6.126]). Factors independently associated with lower mortality were TPE at ICU admission (HR, 0.284; 95%CI, [0.112–0.717]), TPE within one day after ICU admission (HR, 0.449; 95%CI, [0.275–0.907]), and early rituximab therapy (HR, 0.229; 95% CI, [0.111–0.471]). Delayed TPE was associated with significantly higher costs.

Conclusions
Immediate TPE and early rituximab are associated with improved survival in TTP patients. Improved treatments have led to a decline in mortality over time, and alternate outcome variables such as the use of hospital resources or longer term outcomes therefore need to be considered.
Efficacy of a four-tier infection response system in the emergency department during the coronavirus disease-2019 outbreak
Authors: Choi Arom , Kim Ha Yan , Cho Ara , Noh Jiyoung , Park Incheol , Chung Hyun Soo 
Published: August 2021

Introduction
The coronavirus disease (COVID-19) pandemic has delayed the management of other serious medical conditions. This study presents an efficient method to prevent the degradation of the quality of diagnosis and treatment of other critical diseases during the pandemic.

Methods
We performed a retrospective observational study. The primary outcome was ED length of stay (ED LOS). The secondary outcomes were the door-to-balloon time in patients with suspected ST-segment elevation myocardial infarction and door-to-brain computed tomography time for patients with suspected stroke. The outcome measures were compared between patients who were treated in the red and orange zones designated as the changeable isolation unit and those who were treated in the non-isolation care unit. To control confounding factors, we performed propensity score matching, following which, outcomes were analyzed for non-inferiority.

Results
The mean ED LOS for hospitalized patients in the isolation and non-isolation care units were 406.5 min (standard deviation [SD], 237.9) and 360.2 min (SD, 226.4), respectively. The mean difference between the groups indicated non-inferiority of the isolation care unit (p = 0.037) but not in the patients discharged from the ED (p>0.999). The mean difference in the ED LOS for patients admitted to the ICU between the isolation and non-isolation care units was -22.0 min (p = 0.009). The mean difference in the door-to-brain computed tomography time between patients with suspected stroke in the isolation and non-isolation care units was 7.4 min for those with confirmed stroke (p = 0.013), and -20.1 min for those who were discharged (p = 0.012). The mean difference in the door-to-balloon time between patients who underwent coronary angiography in the isolation and non-isolation care units was -2.1 min (p<0.001).

Conclusions
Appropriate and efficient handling of a properly planned ED plays a key role in improving the quality of medical care for other critical diseases during the COVID-19 outbreak.
Detection of Circulating Tumor DNA Methylation in Diagnosis of Colorectal Cancer
Authors: Xu Fei , Yu Shanshan , Han Junyi , Zong Ming , Tan Qi , Zeng Xin , Fan Lieying 
Published: August 2021

INTRODUCTION:
Emerging evidence has demonstrated the potential of the circulating tumor DNA (ctDNA) methylation in the application of cancer diagnosis.

METHODS:
Three genes including Septin9, Syndecan-2 (SDC2), and branched-chain amino acid transaminase 1 (BCAT1), which have been well demonstrated to have aberrant expression in colorectal cancer (CRC) as tumor suppressors, were selected for detection. A total of 234 peripheral plasma samples from 104 patients with CRC and 130 patients with colorectal polyps, and 60 plasma samples from healthy controls, were collected before any treatment. A real-time polymerase chain reaction-based gene panel was used to detect the methylation of Septin9, SDC2, and BCAT1. The composite score (P) was calculated according to the cycle threshold values of the 3 methylated genes using the logistic regression equation.

RESULTS:
The ctDNA methylation of the 3 genes had a significantly higher level in patients with CRC, compared with patients with colorectal polyps and healthy controls. The composite score (P) showed association with tumor stages in CRC but not with the tumor location (colon or rectum). In addition, BCAT1 and Septin9 showed better performance for CRC diagnosis, by which CRC was able to distinguish from polyps with sensitivity of 83.7%, specificity of 93.9%, and area under the curve of 0.908. The diagnostic efficiency was significantly improved by combining composite score (P), carcinoembryonic antigen, and fecal immunochemical test for hemoglobin (area under the curve = 0.962).

DISCUSSION:
The composite score (P) derived from the ctDNA methylation levels of Septin9, SDC2, and BCAT1 can be used for CRC diagnosis with high sensitivity and high specificity. A combination of ctDNA methylation, carcinoembryonic antigen, and fecal immunochemical test for hemoglobin was proved to be the most effective approach to diagnose CRC.
Putting the “Public” in Rhetoric & Public Affairs
Authors: Young Anna M. , Mercieca Jennifer 
Published: August 2021

Abstract
We argue that part of Rhetoric & Public Affairs’ future should center public-facing scholarship in rhetorical studies. We begin by chronicling some of the work colleagues are doing to bridge expert and lay publics: podcasts, popular and trade press interviews, social media content development and management, and activist engagements. Centering public-facing scholarship creates several notable shifts: (1) it changes the “so what?” for traditional scholarship by inviting scholars to think about audiences outside of journal readership; (2) it opens space for different stylistic conventions in scholarly writing; and (3) it indicates that nonexpert audiences are valuable as readers. We note the considerable barriers to entry to public scholarship including gatekeeping, framing public scholarship for tenure, and training. We contend that Rhetoric & Public Affairs could lead other journals through an updated definition of impact that takes into account contemporary modes of circulation and sharing, should accept pieces written for nonexpert readers in rhetoric, and should consider, if possible, making available for public reading one scholarly article every month or every quarter.
Reimagining Public Address
Authors: Childers Jay P. 
Published: August 2021

AbstractAs a subfield of rhetorical studies, public address has been conservative and defensive from the start in its method, theory, politics, and even subject. Even as there has been an expansion of the subject (i.e., the “text” to be studied), the field has, on the whole, remained skeptical of new methods, all critical theories, and alternative political motives. Because of this, the subfield of public address has remained incredibly white and largely male. If the subfield is to continue to exist and, perhaps, thrive, it is time for a clear change in tack. Public address must open its gates widely to the critical methods and theories that can allow for more diverse knowledge production and reorient the field’s political goals. And in a reversal, public address should define itself solely around the study of speeches directed at publics.
A narrativa na imagem
Authors: Kerinska Nikoleta , Baroni Raphaël 
Published: August 2021

Este artigo propõe uma reflexão sobre o potencial narrativo das imagens. Um panorama das definições de narrativa, confrontando suas particularidades traz as últimas tendências da narratologia pós-clássica. A questão da narrativização da imagem é abordada a partir de alguns exemplos artísticos, que representam diferentes relações com a dimensão temporal da narrativa. Levando em consideração as noções de sequencia, intriga e configuração é desenvolvida uma tipologia dos procedimentos de narrativização da imagem estática.
Conceitos fundamentais da matemática
Authors: Lima Luciano Castro , Moises Roberto Perides 
Published: August 2021

Conceitos Fundamentais da matemática pode ser considerado uma das principais obras do matemático português Bento de Jesus Caraça. Nela o autor combina o movimento histórico – lógico de criação de conceitos matemáticos fundamentais como o número, funções. Limites, séries e continuidade. Para além do conteúdo matemático chama a atenção o método de exposição utilizado no livro. Aqui pretendemos expor uma síntese do livro, um apanhado geral desse método e das intenções por trás do que julgamos ser possível conhecer um pouco do autor. Um livro da metade do século passado e que não por isso perdeu sua atualidade. Boa leitura!
Cardiovascular Outcomes in Patients With Mitochondrial Disease in the United States: A Propensity Score Analysis
Authors: Nguyen Tran , Alzahrani Talal , Krepp Joseph , Panjrath Gurusher 
Published: August 2021

Mitochondrial disease comprises a wide range of genetic disorders caused by mitochondrial dysfunction. Its rarity, however, has limited the ability to assess its effects on clinical outcomes. To evaluate this relationship, we collected data from the 2016 National Inpatient Sample, which includes data from >7 million hospital stays. We identified 705 patients (mean age, 22 ± 20.7 yr; 54.2% female; 67.4% white) whose records included the ICD-10-CM code E88.4. We also identified a propensity-matched cohort of 705 patients without mitochondrial disease to examine the effect of mitochondrial disease on major adverse cardiovascular events, including all-cause in-hospital death, cardiac arrest, and acute congestive heart failure.
Patients with mitochondrial disease were at significantly greater risk of major adverse cardiovascular events (odds ratio [OR]=2.42; 95% CI, 1.29–4.57; P=0.005), systolic heart failure (OR=2.37; 95% CI, 1.08–5.22; P=0.027), and all-cause in-hospital death (OR=14.22; 95% CI, 1.87–108.45; P<0.001).
These findings suggest that mitochondrial disease significantly increases the risk of inpatient major adverse cardiovascular events.
Factors affecting student-teacher satisfaction with a multi-college online collaborative course
Authors: Shonfeld Miri 
Published: August 2021

This study examined the factors that may promote student-teachers’ satisfaction with online collaborative learning (OCL). Eighty-four student teachers at the graduate level at three teacher-education colleges in Israel simultaneously completed questionnaires that examined their information and communication technology (ICT) skills, collaboration experience and personality traits. The findings reveal that ICT level, positive experiences with collaborative learning and openness contributed significantly to satisfaction with the collaborative project and accounted for 63% of the variance. Personal traits were found to be mediated by ICT level, and ICT level was in turn mediated by collaborative experience. The results demonstrate the importance of ICT level as a prerequisite for these courses and the significance of preparing the groups and structuring the activities to achieve positive collaborative experiences.
Implications for practice or policy:

University stakeholders may build OCL courses in collaboration with other universities.
University staff can determine how personality issues and ICT level affect students’ success in OCL courses.
Policymakers can better understand the preparation necessary to develop OCL courses.
This case can help educators improve their collaborative programs.
Challenges in a mobile English telecollaborative project: Towards a conceptual model
Authors: Wu Junjie Gavin , Feng Teng Mark , Lindsay Miller 
Published: August 2021

This paper, drawing upon a mobile telecollaborative project, resonates with the rapid development of technology in language learning. We employed the instant messaging app WeChat to create an English telecollaborative environment for two groups of Chinese students to communicate within. Interview data were triangulated with students’ chat transcripts and comments from a teacher’s reflective journal. A mixed-methods approach, including quantitative descriptive analysis, thematic analysis and content analysis, was used to investigate the challenges and the linguistic performance by applying the community of inquiry framework to the students’ chats. The analysis illustrates some of the complexities and challenges of using online apps as a way of communicating in a second language: students expected more teacher support, they struggled to use the app due to their physical environments and they felt that they were not sufficiently well prepared for chatting in an English medium environment. Based on the findings, a conceptual model is proposed for consideration when encouraging students to engage in telecollaborative learning.
Implications for practice or policy:

Teachers should enhance their visibility in mobile telecollaborative projects by promoting participants’ contribution through different facilitation techniques.
Teachers and educators can capitalise on the proposed conceptual model to guide their own design of such online learning experiences for their learners.
Telecollaborative learning can be improved by taking into account various factors such as physical environment, the medium of communication and the potential incentives.
Die Bibliothek Oodi – ihre Entstehungsgeschichte und Bedeutung für die Gesellschaft
Authors: Soininvaara Anna-Maria 
Published: August 2021

Zusammenfassung
Der Artikel stellt die neue öffentliche Bibliothek Oodi in Helsinki, Finnland, vor. An der Entstehung der Bibliothek im Zentrum der Stadt Helsinki waren die Bürger und Bürgerinnen maßgeblich beteiligt. Sie wurden auf vielfältige Art und Weise in die Planungs- und Bauphase der Bibliothek mit einbezogen. Die am häufigsten geäußerten Wünsche der Einwohner und Einwohnerinnen dienten unter anderem als Grundlage für den internationalen Architekturwettbewerb, der für die neue Bibliothek ausgetragen wurde: Man wünschte sich einerseits Ruhe, aber andererseits auch ein umfangreiches Veranstaltungsangebot. Daneben erhoffte man sich einen Ort, an dem Familien mit Kindern Zeit verbringen können, man verschiedenen Hobbys nachgehen und sich zum Studieren oder Arbeiten zurückziehen kann.
Den Wettbewerb gewann das finnische Architekturbüro ALA. In ihrem Entwurf gelang es den Architekten, alle erwähnten Aspekte miteinander zu vereinbaren. Dies wurde durch die Einteilung des Gebäudes in verschiedene Funktionsbereiche auf unterschiedlichen Stockwerken erzielt. Der Siegerentwurf überzeugte durch eine gelungene Kombination aus Funktionalität, Umweltfreundlichkeit, Barrierefreiheit und wunderschöner Architektur.
Oodi ist eine auf die Entwicklung und Testung neuer Methoden und Konzepte ausgerichtete Bibliothek. Die Beteiligung der Bürger und Bürgerinnen an jenen Entwicklungen spielt dabei eine bedeutende Rolle.
Digital ist Trumpf oder die DNB in der Coronavirus-Pandemie
Authors: Oehlschläger Susanne 
Published: August 2021

Zusammenfassung
Seit über einem Jahr beherrscht Corona die Schlagzeilen und das Leben und Arbeiten auch der Bibliotheken und Kultureinrichtungen. Der Beitrag beschreibt, wie die Deutsche Nationalbibliothek während der Coronavirus-Pandemie ihre internen und externen Angebote und Dienste digital erweitert hat und sie weiter ausbauen möchte. Dazu werden zahlreiche Beispiele für virtuelle Treffen der Beschäftigten, für Konferenzen und Veranstaltungen gegeben.
Two strongly convergent self-adaptive iterative schemes for solving pseudo-monotone equilibrium problems with applications
Authors: Pakkaranang Nuttapol , Rehman Habib ur , Kumam Wiyada 
Published: August 2021

Abstract
The aim of this paper is to propose two new modified extragradient methods to solve the pseudo-monotone equilibrium problem in a real Hilbert space with the Lipschitz-type condition. The iterative schemes use a new step size rule that is updated on each iteration based on the value of previous iterations. By using mild conditions on a bi-function, two strong convergence theorems are established. The applications of proposed results are studied to solve variational inequalities and fixed point problems in the setting of real Hilbert spaces. Many numerical experiments have been provided in order to show the algorithmic performance of the proposed methods and compare them with the existing ones.
Posidonius et le traité d’Albinus Sur les incorporels
Authors: Rashed Marwan 
Published: August 2021

Abstract
The reference to Albinus in a refutation of Bardesanes († c. 222) by Ephrem the Syrian († 373) is not unknown to modern commentators. This text, edited and translated into English since the beginning of the twentieth century, is regularly mentioned, albeit rather cursorily, by scholars of Middle Platonism. Although much has been clarified between the first publication of the book just over a century ago and the present day, the following pages aim to continue the exploration. The aim will be to better understand what has so far remained unnoticed: the dependence of Albinus’ work on Posidonius on three crucial points: (1) his classification of incorporeals, (2) his doctrine of comprehensive representation, and (3) the deep relationship between (1) and (2).
Coordinated control and parameters optimization for PSS, POD and SVC to enhance the transient stability with the integration of DFIG based wind power systems
Authors: Bhukya Jawaharlal , Naidu Talada Appala , Vuddanti Sandeep , Konstantinou Charalambos 
Published: August 2021

Abstract
This paper presents stability enhancement of a test system that is connected with a Wind Farm (WF) by using Power System Stabilizer (PSS) for Synchronous Generator (SG) and Power Oscillation Damper (POD) for Static Var Compensator (SVC). This paper also proposes a coordination mechanism for the controller to effectively damp out the oscillations and make the power system more stable by considering the uncertainties. The uncertainty is considered as wind speed variation and wind power penetration and different locations. The Particle Swarm Optimization (PSO) is used to overcome the controller parameter tuning drawbacks and controller coordination. The SG rotor speed deviation is selected as an objective function with various constraints for PSO. The transient stability analysis is carried out by considering large disturbance that is a three-phase fault. The nonlinear dynamic simulation results are obtained by integrating WF and SG replacement with the same rating WF. Evaluation and analysis are performed for various cases and different combination of without and with controllers. From the simulation results, it is noticed that oscillations in the system are minimized, and stability is enhanced at the maximum level. It also observed that the capability of SG and DFIG under three-phase fault is intensified by using PSO for optimized coordinated controller parameters. The robustness and effectiveness of the proposed approaches are evaluated on the IEEE-11 bus test system.
Novel models of power system components for implicit solution of the adjusted power flow problem
Authors: Damodhar Sunil S. 
Published: August 2021

AbstractThe solution of the adjusted power flow problem involves handling power system components whose control characteristics possess operational limits. Examples include generator reactive power limits, tap-changing and phase-shifting transformers, and FACTS devices. While the conventional method involves checking for limit violations in an outer loop drawn around the unadjusted power flow problem being solved by the Newton-Raphson (NR) method, for iterative processes, it is desirable to have smooth, continuously differentiable models implicitly handled within a single loop. A novel formulation for a subset of devices is presented for implicit handling within power flow. The steady state characteristics of tap-changing and phase-shifting transformers, and FACTS devices SVC and STATCOM, can be described using the “cut function”, a piecewise linear function traditionally employed in neural networks. A new approximation of the cut function is used for formulating novel equations describing the steady state characteristics. An augmented set of equations is formed and solved by the NR method, eliminating the need of an outer loop. The efficacy of the proposed method is demonstrated by employing it for plotting bus voltage profiles and determining maximum loadability of test systems. Comparisons with the conventional method show that significant savings in computation can be achieved.
Inflation, Investment and Valuation
Authors: Cornell Bradford , Gerger Richard , Jarrell Gregg A. , Canessa James L. 
Published: August 2021

Abstract
In any context where a discounted cash flow valuation is required, there is the issue of estimating the continuing value. The most common way to do that is to assume that by the terminal horizon the company is in a steady state and is growing at a constant rate. The issue is how to handle inflation. The problem is that it is often done wrong and the impact is typically material. Because there remains significant confusion, in this paper we simplify the analysis by isolating the two key issues and providing example calculations. We show that even at the current 2% level proper treatment of inflation has a sizeable impact on valuation. If inflation were to accelerate as a result of current monetary and fiscal policies, the significance of this issue will increase.
In Search of “That Archimedean Point”: The Development of Selfhood in Kierkegaard’s Journal of Gilleleje
Authors: Bravo Nassim 
Published: August 2021

Abstract
This article offers a philosophical account of the so-called journal of Gilleleje. I would like to argue that in this text from 1835 one can trace the early philosophical musings of Kierkegaard on the existential question of the discovery of the self and the development of selfhood, one of the main motifs in the authorship of the Dane. Additionally, I discuss the literary trends of the 1830s in Golden Age Denmark, particularly the boom of the Danish short novel and Heiberg’s admiration of Goethe, analyzing in what way this local context impacted Kierkegaard’s ideas in the journal of Gilleleje.