bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value Added Intellectual Capital Memoderasi Pengaruh, Leverage, Risiko Sitematis, Growth Opportunities, dan Firm SizeTerhadap Earning Response Coefficient (ERC)
Authors: Gunawan Ari , Anwar Choirul , Djaddang Syahril 
Published: June 2021

Objective of this research is to test value added intellectual capital to moderate influence, leverage, systematic risk, growth opportunities and firm size against earnings response coefficient (ERC). This research was conducted on listed automotive companies on the BEI in the period 2013-2017 with purposive sampling technique. The number of samples we obtained is 58 companies. Data analysis technique that we used in this research is Structure Equation Modeling technique WarpPLS 6.0. Results of hypothesis testing by using Structure Equation Modeling technique SEM-PLS, is that: Leverage does not affect the ERC, the results of this study is in line with managerial perspective (Trade Off Theory). Systematic risk have negative affect with the ERC, the results of this study is in line with the risk motive. Growth Opportunities positively affect the ERC, The results of this study is in line with positive accounting theory. Firm Size does not affect the ERC, it means the company is not able to take advantage of owned assets to create company profitability. VAIC does not moderate the relationship between Leverage, Systematic Risk, Growth Opportunities, Firm Size against ERC. Value Added Intelectual capital has a high subjectivity because VAIC measurements can not be done properly against corporate IC, because there is no appropriate measuring tool to calculate the company IC.
Abstrak
Studi ini bertujuan untuk melakukan pengujian value added intellectual capital memoderasi pengaruh,leverage, risiko sistematis, growthopportunities dan firm size terhadap earning responsecoefficient (ERC). Penelitian ini dilakukan pada perusahaaan otomotif yang terdaftar di BEI pada periode 2013-2017 dengan teknik purposive sampling diperoleh jumlah sampel sebanyak 58 perusahaan. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik Struktur Equation Modeling WarpPLS 6.0. . Dari hasil pengujian hipotesis dengan mengunakan teknik Struktur Equation Modeling SEM-PLS, dapat disimpulkan bahwa : Leverage tidak berpengaruh terhadap ERC, hasil penelitian ini searah dengan prespektif manajerial (Teori Trade Off). Resiko sistematis berpengaruh negatif terhadap ERC, hasil penelitian ini ini searah dengan motif risiko.Growth Opportunities berpengaruh positif terhadap ERC, Hasil penelitian ini searah dengan teori akuntnasi positif.Firm Sizetidak berpengarug terhadap ERCartinya perusahaan tidak mampu memanfaatkan aset yang dimiliki untuk menciptakan profitabilitas perusahaan.VAIC tidak memoderasi hubungan antara Leverage,Resiko sistematis, Growth Opportunities,Firm Size terhadap ERC. Value Added Intelectual capital memiliki subyektifitas yang tinggi karena pengukuran VAIC belum dapat dilakukan dengan tepat terhadap IC perusahaan, karena belum ada alat ukur yang tepat untuk menghitung IC perusahaan.
KataKunci:Earning Response Coefficient, Leverage,Resiko sistematis, Growth Opportunities
Firm Size, VAIC
Construction of Two Alternative Polyadenylation Signatures to Predict the Prognosis of Sarcoma Patients
Authors: Hu Chuan , Liu Chuan , Li Jianyi , Yu Tengbo , Dong Jun , Chen Bo , Du Yukun , Tang Xiaojie , Xi Yongming 
Published: June 2021

BackgroundIncreasing evidence indicates that alternative polyadenylation (APA) is associated with the prognosis of cancers.MethodsWe obtained gene expression and APA profiles of 259 sarcoma patients from the TCGA dataportal and TC3A database, respectively. The prognostic signatures, clinical nomograms, and regulatory networks were studied by integrated bioinformatics analyses. Then, the immune cell infiltration profile was obtained from the ImmuCellAI. The association between APA-based signature and immune cells was studied.ResultsA total of 61 and 38 APA events were identified as overall survival (OS)- and progress free-survival (PFS)-related biomarkers, respectively. Two signatures were generated. The area under the curves (AUC) values of OS signature were 0.900, 0.928, and 0.963 over 2-, 4-, and 6-years, respectively. And the AUC values of PFS signature at 2-, 4-, and 6-years were 0.826, 0.840, and 0.847, respectively. Overall and subgroup analyses indicated that high-risk patients had a worse prognosis than low-risk patients (all p-values &lt; 0.05). In addition, immunomics analyses indicated that there are different patterns of immune cell infiltration between low- and high-risk patients. Furthermore, two clinical-APA nomograms were established and the C-indexes were 0.813 and 0.809 for OS nomogram and PFS nomogram, respectively. Finally, two APA regulatory networks were constructed. FIP1L1-VPS26B was identified as a key regulating relationship and validated in the pan-cancer analyses.ConclusionIn this study, we identified prognostic predictors based on APA events with high accuracy for risk stratification in sarcoma patients and uncovered interesting regulatory networks in sarcoma that could be underlying mechanisms. This study not only provides novel potential prognostic biomarkers but promote precision medicine and provide potential novel research interests for immunotherapy.
Real-Time In Vivo Detection and Monitoring of Bacterial Infection Based on NIR-II Imaging
Authors: Feng Sijia , Li Huizhu , Liu Chang , Chen Mo , Sheng Huaixuan , Huang Mingru , Li Yunxia , Chen Jun , Zhang Jian , Hao Yuefeng , Chen Shiyi 
Published: June 2021

Treatment according to the dynamic changes of bacterial load in vivo is critical for preventing progression of bacterial infections. Here, we present a lead sulfide quantum dots (PbS QDs) based second near-infrared (NIR-II) fluorescence imaging strategy for bacteria detection and real-time in vivo monitoring. Four strains of bacteria were labeled with synthesized PbS QDs which showed high bacteria labeling efficiency in vitro. Then bacteria at different concentrations were injected subcutaneously on the back of male nude mice for in vivo imaging. A series of NIR-II images taken at a predetermined time manner demonstrated changing patterns of photoluminescence (PL) intensity of infected sites, dynamically imaging a changing bacterial load in real-time. A detection limit around 102–104 CFU/ml was also achieved in vivo. Furthermore, analysis of pathology of infected sites were performed, which showed high biocompatibility of PbS QDs. Therefore, under the guidance of our developed NIR-II imaging system, real-time detection and spatiotemporal monitoring of bacterial infection in vivo can be achieved, thus facilitating anti-infection treatment under the guidance of the dynamic imaging of bacterial load in future.
Acute Mechanical Performance of Magmaris vs. DESolve Bioresorbable Scaffolds in a Real-World Scenario
Authors: Boeder Niklas F. , Dörr Oliver , Koepp Tim , Blachutzik Florian , Achenbach Stephan , Elsässer Albrecht , Hamm Christian W. , Nef Holger M. 
Published: June 2021

Background: After the bioresorbable PLLA-based vascular scaffold (Absorb BVS) was taken from the market due to its high adverse event rates, a magnesium-based scaffold (Magmaris) was introduced.Objective: To compare the acute performance of the sirolimus-eluting magnesium alloy Magmaris scaffold with that of the novolimus-eluting PLLA-based DESolve scaffold in terms of appropriate scaffold deployment using optical coherence tomography (OCT).Methods and Results: Data from the final OCT pullback of 98 patients were included (19 Magmaris, 79 DESolve) and analyzed at 1-mm intervals. The following indices were calculated: mean and minimal area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity index, symmetry index, strut fracture, and edge dissection. OCT showed a minimum lumen area for Magmaris vs. DESolve of 6.6 ± 1.6 vs. 6.0 ± 1.9 (p = 0.06). Scaffolds with residual area stenosis &gt;20% were predominantly seen in the DESolve group (15.8 vs. 46.8%; p = 0.01). The mean eccentricity index did differ significantly (0.74 ± 0.06 vs. 0.63 ± 0.09; p &lt; 0.001). No fractures were observed for Magmaris scaffolds, but 15.2% were documented for DESolve BRS (p &lt; 0.001). Incomplete scaffold apposition area was significantly higher in the DESolve group (0.01 ± 0.02 vs. 1.05 ± 2.32 mm2; p &lt; 0.001).Conclusion: This is the first study to compare the acute mechanical performance between Magmaris and DESolve in a real-world setting. The acute mechanical performance of Magmaris BRS seems to be superior to that of DESolve BRS, whereas OCT showed a good acute mechanical performance for both BRS in terms of generally accepted imaging criteria.
A Lacustrine Biomarker Record From Rebun Island Reveals a Warm Summer Climate in Northern Japan During the Early Middle Holocene Due to a Stronger North Pacific High
Authors: Yamamoto Masanobu , Wang Fangxian , Irino Tomohisa , Suzuki Kenta , Yamada Kazuyoshi , Haraguchi Tsuyoshi , Gotanda Katsuya , Yonenobu Hitoshi , Chen Xuan-Yu , Tarasov Pavel 
Published: June 2021

The summer climate of northern Japan since the last glacial period has likely been determined by atmospheric and oceanic dynamics, such as changes in the North Pacific High, the position of the westerlies, the Kuroshio Current, the Tsushima Warm Current (TWC), and the East Asian summer monsoon. However, it is unclear which factor has been most important. In this study, we analyzed leaf wax δ13C and δD and glycerol dialkyl glycerol tetraethers (GDGTs) in sediments from Lake Kushu, Rebun Island, northern Japan, and discuss changes in climate over the past 17,000 years. The GDGT-based temperature, the averaged chain length, δ13C and δD of long-chain n-fatty acids indicated that the climate was cold during the Oldest Dryas period ∼16 ka and warm in the early Middle Holocene from ∼9 to 6 ka. This climate change is consistent with the sea surface temperature in the Kuroshio–Oyashio transition, but inconsistent with changes in the TWC in the Sea of Japan. The results imply that the summer climate of northern Japan was controlled mainly by changes in the development of the North Pacific Highviachanges in the position of the westerly jet and East Asian summer monsoon rainfall, whereas the influence of the TWC was limited over a millennial timescale.
Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals
Authors: Maushart Claudia Irene , Senn Jaël Rut , Loeliger Rahel Catherina , Kraenzlin Marius E. , Müller Julian , Becker Anton S. , Balaz Miroslav , Wolfrum Christian , Burger Irene A. , Betz Matthias Johannes 
Published: June 2021

Thyroid hormone (TH) is an important regulator of mammalian metabolism and facilitates cold induced thermogenesis (CIT) in brown adipose tissue (BAT). Profound hypothyroidism or hyperthyroidism lead to alterations in BAT function and CIT. In euthyroid humans the inter-individual variation of thyroid hormones is relatively large. Therefore, we investigated whether levels of free thyroxine (T4) or free triiodothyronine (T3) are positively associated with CIT in euthyroid individuals. We performed an observational study in 79 healthy, euthyroid volunteers (mean age 25.6 years, mean BMI 23.0 kg · m-2). Resting energy expenditure (REE) was measured by indirect calorimetry during warm conditions (EEwarm) and after a mild cold stimulus of two hours (EEcold). CIT was calculated as the difference between EEcold and EEwarm. BAT activity was assessed by 18F-FDG-PET after a mild cold stimulus in a subset of 26 participants. EEcold and CIT were significantly related to levels of free T4 (R2 = 0.11, p=0.0025 and R2 = 0.13, p=0.0011, respectively) but not to free T3 and TSH. Cold induced BAT activity was also associated with levels of free T4 (R2 = 0.21, p=0.018). CIT was approximately fourfold higher in participants in the highest tertile of free T4 as compared to the lowest tertile. Additionally, free T4 was weakly, albeit significantly associated with outdoor temperature seven days prior to the respective study visit (R2 = 0.06, p=0.037). These finding suggests that variations in thyroid hormone levels within the euthyroid range are related to the capability to adapt to cool temperatures and affect energy balance.
Study on Dispersion of Carbon Dioxide over the Shrubbery Region
Authors: Huiru Wang , Zhanping You , Fan Mo , Bin Liu , Peng Han 
Published: June 2021

In the carbon capture and storage (CCS) infrastructure, the risk of a high-pressure buried pipeline rupture possibly leads to catastrophic accidents due to the release of tremendous amounts of carbon dioxide (CO2). Therefore, a comprehensive understanding of the effects of CO2 dispersion pattern after release from CCS facilities is essential to allow the appropriate safety precautions to be taken. Due to variations in topography above the pipeline, the pattern of CO2 dispersion tends to be affected by the real terrain features, such as trees and hills. However, in most previous studies, the dynamic impact of trees on the wind field was often approximated to linear treatment or even ignored. In this article, a computational fluid dynamics (CFD) model was proposed to predict CO2 dispersion over shrubbery areas. The shrubs were regarded as a kind of porous media, and the model was validated against the results from experiment. It was found that shrubbery affected the flow field near the ground, enhancing the lateral dispersion of CO2. Compared with that of the shrub-free terrain, the coverage area of the three shrub terrains at 60 s increased by 8.1 times, 6.7 times, and 9.1 times, respectively. The influence of shrub height and porosity on CO2 dispersion is nonlinear. This research provides reliable data for the risk assessment of CCS.
Characteristics and Mechanism of Pb2+ Adsorption From Aqueous Solution Onto Biochar Derived From Microalgae and Chitosan-Modified Microalgae
Authors: Liu Weigang , Li Kelin , Hu Xi , Hu Xinjiang , Zhang Ruibin , Li Qi 
Published: June 2021

With increasing aquatic heavy metal pollution and eutrophication, using algae to prepare novel adsorbent materials for remediating heavy metal pollution has recently attracted research attention worldwide. However, microalgae biochar exhibits poor adsorption capacity in certain conditions, and little is known regarding microalgae biochar modification using chitosan. Chitosan has been previously used to directly modify microalgae biochar; however, in this study, chitosan is used to modify algae powder used to prepare biochar. Therefore, in this study, chitosan was used as a microalgae biochar modifier to enhance its applicability and adsorption capacity. Accordingly, two new types of microalgae biochars, chitosan-biochar (CTS-BC) and biochar-chitosan (BC-CTS), were developed as an adsorbent material using Clostridium and adding chitosan as a modifier at different stages of its preparation. These developed microalgae biochars were characterized using Brunauer–Emmett–Teller surface area,X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy. The adsorption processes of these biochars can be well described by a pseudo-second-order kinetic model. Pb2+ was dominantly adsorbed by microalgal biochar through chemisorption. Following chitosan modification, several mino, cyano, and aromatic ring groups were attached onto the surface of the microalgal biochar. The Pb2+ adsorption capacity of the chitosan-modified biochar was better than that of the unmodified biochar. The maximum Pb2+ adsorption capacity of CTS-BC under acidic conditions (pH = 5) was 9.41 mg g−1, whereas that of BC-CTS under alkaline conditions (pH = 9) was 9.94 mg g−1, both were higher than that of unmodified microalgae biochar under similar conditions. CTS-BC and BC-CTS possessed excellent stability and reusability for Pb(II) adsorption, the adsorption efficiency still remained above 50% even after three cycles. This study demonstrated that adsorbent materials having a stronger heavy-metal adsorption capacity can be prepared by adding chitosan during different stages of the microalgae biochar preparation process.
Identifying Hypoxia Characteristics to Stratify Prognosis and Assess the Tumor Immune Microenvironment in Renal Cell Carcinoma
Authors: Zhang Zhenan , Li Qinhan , Wang Feng , Ma Binglei , Meng Yisen , Zhang Qian 
Published: June 2021

Background: Renal cell carcinoma (RCC) is a common malignant tumor worldwide, and immune checkpoint inhibitors are a new therapeutic option for metastatic RCC. Infiltrating immune cells in the tumor microenvironment (TME) play a critical part in RCC biology, which is important for tumor therapy and prediction. Hypoxia is a common condition that occurs in the TME and may lead to RCC immunosuppression and immune escape. This study was conducted to analyze the extent of the hypoxia immune microenvironment in the TME of RCC and develop a hypoxia-related risk model for predicting the prognosis of patients with RCC.Methods: The gene expression profiles of 526 patients with RCC were downloaded from The Cancer Genome Atlas database. Combined with the hallmark-hypoxia gene dataset downloaded from Gene Set Enrichment Analysis, prognosis-related hypoxia genes were selected by survival analysis. A protein–protein interaction network and functional enrichment analysis were performed. A hypoxia-related risk model predicting the prognosis of patients with RCC was established using the least absolute shrinkage and selection operator. Data of 91 cases downloaded from the International Cancer Genome Consortium (ICGC) database were used for validation. CIBERSORT was applied to analyze the fractions of 22 immune cell types in the TME of RCC between low- and high-risk groups. The expression profiles of immunomodulators and immunosuppressive cytokines were also analyzed.Results: Ninety-three genes were significantly associated with poor overall survival of patients with RCC and were mainly involved in 10 pathways. Using the established hypoxia-related risk model, the receiver operating characteristic curves showed an accuracy of 76.1% (95% CI: 0.719–0.804), and Cox proportional hazards regression analysis revealed that the model was an independent predictor of the prognosis of patients with RCC [hazard ratio (HR) = 2.884; 95% CI: 2.090–3.979] (p &lt; 0.001). Using the ICGC database, we verified that the low-risk score group had a better overall survival outcome than the high-risk group. Additionally, dividing the hypoxia risk score into high-risk and low-risk groups could predict the immune microenvironment of RCC.Conclusions: We demonstrated that a hypoxia-related risk model can be used to predict the outcomes of patients with RCC and reflect the immune microenvironment of RCC, which may help improve the overall clinical response to immune checkpoint inhibitors.
Correlations Between the Characteristics of Alternative Splicing Events, Prognosis, and the Immune Microenvironment in Breast Cancer
Authors: Deng Youyuan , Zhao Hongjun , Ye Lifen , Hu Zhiya , Fang Kun , Wang Jianguo 
Published: June 2021

ObjectiveAlternative splicing (AS) is the mechanism by which a few genes encode numerous proteins, and it redefines the concept of gene expression regulation. Recent studies showed that dysregulation of AS was an important cause of tumorigenesis and microenvironment formation. Therefore, we performed a systematic analysis to examine the role of AS in breast cancer (Breast Cancer, BrCa) progression.MethodsThe present study included 993 BrCa patients from The Cancer Genome Atlas (TCGA) database in the genome-wide analysis of AS events. We used differential and prognostic analyses and found differentially expressed alternative splicing (DEAS) events and independent prognostic factors related to patients’ overall survival (OS) and disease-free survival (DFS). We divided the patients into two groups based on these AS events and analyzed their clinical features, molecular subtyping and immune characteristics. We also constructed a splicing factor (SF) regulation network for key AS events and verified the existence of AS events in tissue samples using real-time quantitative PCR.ResultsA total of 678 AS events were identified as differentially expressed, of which 13 and 10 AS events were independent prognostic factors of patients’ OS and DFS, respectively. Unsupervised clustering analysis based on these prognostic factors indicated that the Cluster 1 group had a better prognosis and more immune cell infiltration. SFs were significantly related to the expression of AS events, and AA-RPS21 was significantly upregulated in tumors.ConclusionAlternative splicing expands the mechanism of breast cancer progression from a new perspective. Notably, alternative splicing may affect the patient’s prognosis by affecting the infiltration of immune cells. Our research provides important guidance for subsequent studies of AS in breast cancer.
The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients
Authors: Yang Min , Liu Jia Wei , Zhang Yu Ting , Wu Gang 
Published: June 2021

ObjectiveTo analyze the expression of macrophages, AIM, TGF-β1 in the kidney of IgAN patients, and to explore the role of macrophages, AIM, TGF-β1 in the progression of renal fibrosis in IgAN patients.MethodsThe paraffin specimens of renal tissue from 40 IgAN patients were selected as the observation group. At the same time, paraffin specimens of normal renal tissue from 11 patients treated by nephrectomy were selected as the normal control group. We observed the distribution of macrophages, the expression of AIM and TGF-β1 by immunohistochemical staining and/or immunofluorescence.ResultThe number of M0, M1, M2 macrophages could be found increased in IgAN patients. M0 macrophages are mainly polarized towards M2 macrophages. The expression of AIM and TGF-β1 were significantly higher in IgAN patients than in NC. M2 macrophage, AIM and TGF-β1 were positively correlated with serum creatinine and 24-hour proteinuria, but negatively correlated with eGFR. M2 macrophages, AIM, TGF-β1 were positively correlated with fibrotic area.ConclusionM2 macrophages, AIM and TGF-β1 play important roles in the process of IgAN fibrosis, and the three influence each other.