bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trio elétrico ou bandwagon? Um estudo das estratégias de tradução de referentes culturais em textos turísticos
Authors: Marqueze Giovana Martins de Castro 
Published: October 2021

Para que o fluxo de turistas estrangeiros que chegam ao Brasil tenha acesso a informações sobre os serviços oferecidos pelo setor turístico, textos turísticos são produzidos em larga escala e em diversos idiomas. Como é de se esperar, referentes culturais abundam nesses textos, sendo um desafio constante com o qual os tradutores devem lidar. Dessa forma, à luz da teoria funcionalista da tradução de Nord (1991, 1997) e de Reiss e Vermeer (1984) e com a Linguística de Corpus como metodologia, analisamos as traduções do português para o inglês de textos turísticos sobre o Brasil publicados pela EMBRATUR a fim de descobrir quais estratégias são empregadas na tradução de referentes culturais e se elas colaboram para o cumprimento do propósito desses textos na cultura-meta. As estratégias são descritas com base na lista de estratégias para tradução de referentes culturais proposta por Marco (2002).
The Impact of Corequisite Math on Community College Student Outcomes:
Evidence from Texas
Authors: Meiselman Akiva Yonah , Schudde Lauren 
Published: October 2021

Abstract
Developmental education (dev-ed) aims to help students acquire knowledge and skills necessary to succeed in college-level coursework. The traditional prerequisite approach to postsecondary dev-ed—where students take remedial courses that do not count toward a credential—appears to stymie progress toward a degree. At community colleges across the country, most students require remediation in math, creating a barrier to college-level credits under the traditional approach. Corequisite coursework is a structural reform that places students directly into a college-level course in the same term they receive dev-ed support. Using administrative data from Texas community colleges and a regression discontinuity design, we examine whether corequisite math improves student success compared with traditional prerequisite dev-ed. We find that corequisite math quickly improves student completion of math requirements without any obvious drawbacks, but students in corequisite math were not substantially closer to degree completion than their peers in traditional dev-ed after three years.
The Starting-Points for Knowledge
Authors: Shogry Simon 
Published: October 2021

Abstract
This paper examines some neglected Chrysippean fragments on insecure apprehension (κατάληψις). First, I present Chrysippus’ account of how non-Sages can begin to fortify their insecure apprehension and upgrade it into knowledge (ἐπιστήμη). Next, I reconstruct Chrysippus’ explanation of how sophisms and counter-arguments lead one to abandon one’s insecure apprehension. One such counter-argument originates in the sceptical Academy and targets the Stoic claim that insecure apprehension can be acquired on the basis of custom (συνήθεια). I show how Chrysippus could defend the possibility of custom-based apprehension, while also denying that there is custom-based knowledge.
Properties of coherent structures over Paris: a study based on an automated classification method for Doppler lidar observations
Authors: Cheliotis Ioannis , Dieudonné Elsa , Delbarre Hervé , Sokolov Anton , Dmitriev Egor , Augustin Patrick , Fourmentin Marc , Ravetta François , Pelon Jacques 
Published: October 2021

AbstractThe studies related to the coherent structures in the atmosphere, using Doppler wind lidar observations, so far relied on the manual detection and classification of the structures in the lidar images, making this process time-consuming. We developed an automated classification based on texture analysis parameters and the quadratic discriminant analysis algorithm for the detection of medium-to-large fluctuations and coherent structures recorded by single Doppler wind lidar quasi-horizontal scans. The algorithm classified a training dataset of 150 cases into four types of patterns, namely streaks (narrow stripes), rolls (wide stripes), thermals (enclosed areas) and “others” (impossible to classify), with 91% accuracy. Subsequently, we applied the trained algorithm to a dataset of 4577 lidar scans recorded in Paris, atop a 75 m tower for a 2-month period (September-October 2014). The current study assesses the quality of the classification by examining the physical properties of the classified cases. The results show a realistic classification of the data: with rolls and thermals cases mostly classified concurrently with a well-developed atmospheric boundary layer and the streaks cases associated with nocturnal low-level jets (nllj) events. Furthermore, rolls and streaks cases were mostly observed under moderate or high wind conditions. The detailed analysis of a four-day period reveals the transition between the types. The analysis of the space spectra in the direction transverse to the mean wind, during these four days, revealed streaks spacing of 200 to 400 m, and rolls sizes, as observed in the lower level of the mixed layer, of approximately 1 km.
The value of systematic follow-up imaging for assessing pseudoaneurysm formation after blunt and penetrating liver injury: A level 1 trauma centre experience
Authors: Patel Neeral R , Mehdi Aia S , Sandhu Amandeep , Mallon Dermot , Dick Elizabeth , Batrick Nicola , Kashef Elika 
Published: October 2021

Introduction Hepatic pseudoaneurysm (HPA) is a rare but potentially life-threatening sequelae of blunt or penetrating liver trauma. At our institution, an imaging protocol for liver injury patients has been developed, with repeat computed tomographic (CT) angiography of the liver 48–72 h post-admission to assess for HPA. The purpose of this study was to evaluate the utility of this imaging pathway in liver trauma for the detection of HPAs. Methods A retrospective analysis was performed on patients who were admitted to our institution between January 2014 and January 2018, found to have either blunt or penetrating liver injury on initial CT imaging. Data collection included mechanism of injury, injury severity score (ISS), American Association for the Surgery of Trauma (AAST) liver injury score, initial and follow-up CT findings and secondary intervention. Results During the study period, 149 major trauma patients were admitted with liver injuries (mean age 35.6 years; 72% male, 28% female). Seventy two percent of patients suffered blunt (median ISS = 29; median AAST = 2.89) and 28% patients suffered penetrating injuries (median ISS = 16; median AAST = 2.88). The mean time to follow-up CT was 46.1 h. Follow-up CT identified 8 (5.4%) HPAs. 5 (62.5%) of these patients were treated with embolization. ISS and AAST were not associated with pseudoaneurysm formation according to logistic regression analysis; however, ISS (OR 1.06 [1.02, 1.09; p < 0.05]) and AAST (OR 2.24, [1.31, 3.83; p < 0.05]) were associated with requirement for embolization. Conclusion Our experience indicates a role for early detection of HPAs using a dedicated trauma imaging pathway.
Association Between Blood and Lymphocyte Levels of Cyclosporin A and Infectious Complications in Renal Transplant Patients
Authors: Milane Aline , Abou-Abbas Linda , Osmani Lara , Saber Naja , Mefleh Nadine , Barbari Antoine 
Published: October 2021

Objectives This study aims to investigate a potential association between whole blood and lymphocyte Cyclosporin A (CyA) levels and the occurrence and frequency of infectious complications in kidney transplant patients. Methods The study involves 130 kidney transplant recipients who received CyA in addition to Mycophenolate Mofetil and steroids. CyA whole blood trough and maximum level (CyA BL0 and CyA BLm) as well as the corresponding levels in the lymphocytes (CyA L0 and CyA Lm) were measured for 6 months post-transplantation. Results Cytomegalovirus (CMV) as well as urinary tract infections (UTIs) were the most commonly diagnosed with an incidence of 24.6% and 26.2%, respectively. Only CyA L0 showed a significant association with CMV infection occurrence (adjusted OR = 1.051, 95% CI .997–1.025, P-value 0.046). A positive linear correlation was found between CyA BL0, CyA BLm and CyA Lm and the number of CMV episodes per patient. Conclusion We showed an association between the CMV infections occurrence and the trough lymphocyte level of CyA (CyA L0). Both lymphocyte CyA levels also correlated with the frequency of CMV infections. Further studies are needed to establish the optimal range of both CyA blood and lymphocyte levels and decrease the risk of opportunistic infections in high risk patients.
Observed Characteristics Associated with Diabetes Device Use Among Teens with Type 1 Diabetes
Authors: Chen Charlotte W. , Tinsley Liane J. , Volkening Lisa K. , Anderson Barbara J. , Laffel Lori M. 
Published: October 2021

Background: Despite advancements in diabetes technologies, disparities remain with respect to diabetes device use in youth with type 1 diabetes (T1D). We compared sociodemographic, diabetes, and psychosocial characteristics associated with device (pump and continuous glucose monitor [CGM]) use in 13- to 17-year-old teens with T1D. Materials/Methods: Data were derived from a multicenter clinical trial to optimize self-care and glycemic control in teens with T1D. We categorized teens as pump users versus non-users and CGM users versus non-users based on their diabetes device usage. Chi-square and t-tests compared characteristics according to device use. Results: The sample comprised 301 teens (50% female) with baseline mean ± SD age 15.0 ± 1.3 years, T1D duration 6.5 ± 3.7 years, and HbA1c 8.5 ± 1.1% (69 ± 12 mmol/mol). Two-thirds (65%) were pump users, and 27% were CGM users. Pump users and CGM users (vs. non-users) were more likely to have a family annual household income ≥$150,000, private health insurance, and a parent with a college education (all P < .001). Pump users and CGM users (vs. non-users) also performed more frequent daily blood glucose (BG) checks (both P < .001) and reported more diabetes self-care behaviors (both P < .05). Pump users were less likely to have baseline HbA1c ≥9% (75 mmol/mol) ( P = .005) and to report fewer depressive symptoms ( P = .02) than pump non-users. Parents of both CGM and pump users reported a higher quality of life in their youth ( P < .05). Conclusion: There were many sociodemographic, diabetes-specific, and psychosocial factors associated with device use. Modifiable factors can serve as the target for clinical interventions; youth with non-modifiable factors can receive extra support to overcome potential barriers to device use.
Valgus Control Feedback and Taping Improves the Effects of Plyometric Exercises in Women With Dynamic Knee Valgus
Authors: Shams Fereshteh , Hadadnezhad Malihe , Letafatkar Amir , Hogg Jennifer 
Published: October 2021

Background: Female athletes are more predisposed to anterior cruciate ligament (ACL) injuries in comparison with their male counterparts. Research on ACL injury prevention strategies has demonstrated beneficial effects of plyometric exercises and feedback (FB) during the exercises. FB has resulted in reductions in vertical ground-reaction force and kinematic risk factors associated with ACL injury. Furthermore, taping (TP) may draw attention to the restriction created by the tape and serve as real-time biofeedback. The additional influence of FB and TP on plyometric exercises has not been determined. Hypothesis: FB and TP interventions delivered during plyometric exercises would result in positive changes in biomechanics and muscle onset in female athletes displaying dynamic knee valgus. Design: Controlled trial. Setting: University research laboratory. Level of Evidence: Level 2. Methods: Forty-eight active female athletes were divided into 3 groups: control (n = 16), plyometric training with FB (n = 16), and plyometric training with TP (n = 16). The 2 experimental groups performed a 6-week exercise program with either FB or TP. The control group continued its regular team schedule. Knee joint position sense, landing error scoring system (LESS), and the onset of muscle activation (the point at which muscle activation exceeds 3 standard deviations over baseline and continued above this threshold for at least 25 ms) before landing for the rectus femoris, vastus medialis, vastus lateralis, gluteus medius, semitendinosus, and biceps femoris during pre- and posttests were measured. Results: The vastus lateralis onset later in the TP group compared with the FB group ( d [95% CI] = 0.64 [0.35-0.82], P = 0.01). Joint position sense accuracy improved only in the TP group ( d = −0.63, P = 0.001). Both the FB ( d = −0.85, P = 0.001), and TP ( d = −0.82, P = 0.001) groups improved in LESS scores. Conclusion: The results of the present study showed that plyometric exercises with FB or TP affect LESS and the onset of the vastus lateralis in active uninjured women with dynamic knee valgus, while TP improves joint position sense. Therefore, when more accurate joint position sense is desired, practitioners may use plyometric with TP. If an improved LESS score is desired, plyometrics with either TP or FB are acceptable. Clinical Relevance: Our findings indicate that female athletes may benefit more when completing a plyometric training program with a TP versus an FB. Trainers, coaches, and clinicians should consider utilizing instructions that promote an external focus when implementing plyometric training programs with male athletes.
Rapamycin-induced M2 macrophage autophagy promotes the migration and invasion of bladder cancer cells via increased IL-10 secretion
Authors: Guo Yuanyuan , Li Zhong , Cao Zhenxue , Ma Tantu , Mei Juan , Sun Wei , Gao Wuyue , Liu Beibei , Liu Jianmin , Wang Rui 
Published: October 2021

Intrduction: Rapamycin is an mTOR inhibitor and a prominent inducer of autophagy in cancer cells and tumor interstitial cells. Macrophages are the primary type of immune cells observed in the tumor microenvironment and serve varying roles in the progression of cancer by polarizing into distinct phenotypes. However, whether rapamycin-induced macrophage autophagy influences bladder cancer remains unclear. Methods: THP-1 cells were successfully polarized into M1 or M2 macrophages, which were identified by detecting CD86 (M1) or CD206 (M2) expressions using flow cytometry and measuring M1/M2-related mRNA expressions using reverse transcription-quantitative PCR. Rapamycin was employed for inducing autophagy, and then the influences of enhanced autophagic M1 and M2 macrophages on migration and invasion of bladder cancer cells were confirmed by wound healing and Transwell assay in the co-culture model. Furthermore, the gene and protein expressions of IL-10 and the underlying role are still unclear. Results: Rapamycin significantly increased autophagy levels in M1 and M2 macrophages, while only autophagy-enhanced M2 macrophages facilitated the migration and invasion of bladder cancer cells. Furthermore, rapamycin increased IL-10 secretion from M2 macrophages, which mediated the effects of M2 macrophages on migration and invasion of bladder cancer. Conclusion: Rapamycin induces M2 macrophage autophagy and promotes the migration and invasion of bladder cancer by increasing IL-10 secretion, suggesting that M2 macrophage autophagy is an underlying target of rapamycin in treating bladder cancer.
Assessment of Anterolateral Ligament of the Knee After Primary Versus Revision Anterior Cruciate Ligament Reconstruction
Authors: Suh Dongwhan , Chang Moon Jong , Park Hyung Jun , Chang Chong Bum , Kang Seung-Baik 
Published: October 2021

Background: The anterolateral ligament of the knee (ALL) is a component of the lateral complex that stabilizes the structure against rotational force and may be associated with the outcome of anterior cruciate ligament (ACL) reconstruction (ACLR). Purpose: To (1) find whether the visibility of the structure of the ALL is different in primary and revision ACLR groups, (2) determine whether the abnormal findings of the ALL structure on magnetic resonance imaging (MRI) scans are associated with type of trauma in ACL injury and mode of graft failure, and (3) determine whether there are differences in knee functional scores between patients with or without abnormal findings of the ALL structure on MRI scans in primary and revision ACLR groups. Study Design: Cohort study; Level of evidence, 3. Methods: This retrospective study included 40 patients who underwent primary ACLR and 39 patients who underwent revision ACLR. Conventional MRI (1.5-T) scans taken before primary or revision ACLR were obtained and analyzed for visibility of the ALL, frequency and degree of injury of the ALL, and ALL signal anomalies. We also evaluated 1-year postoperative functional knee scores using the subjective International Knee Documentation Committee and Lysholm scores. Results: Visibility of the ALL was better in the primary ACLR group than the revision ACLR group (38% vs 14%; P = .041). The primary ACLR group showed a lower degree of injury across the femoral, meniscal, and tibial attachment sites than did the revision ACLR group (30% vs 13%, 41% vs 8%, and 62% vs 26%, respectively). Relative signal anomaly of the ALL was more frequent in the case of contact versus noncontact trauma of the ACL (85% vs 15%; P = .035), while absolute signal anomaly was equally observed between cases of contact and noncontact trauma in the primary ACLR group (50% vs 50%). No association was observed between ALL signal anomalies and 1-year postoperative functional knee scores. Conclusion: The revision ACLR group offered less visibility and showed a tendency for more frequent, higher degree of injury to the structure of the ALL. Regardless of observational differences between the 2 groups, no definite relevance was observed between the image and the functional outcome. For the assessment of the ALL, routinely performed conventional MRI alone is insufficient to make a clinical decision.
Deleterious protein-coding variants in diverse cattle breeds of the world
Authors: Subramanian Sankar 
Published: October 2021

AbstractThe domestication of wild animals has resulted in a reduction in effective population sizes, which can affect the deleterious mutation load of domesticated breeds. In addition, artificial selection contributes to the accumulation of deleterious mutations because of an increased rate of inbreeding among domesticated animals. Since founder population sizes and artificial selection differ between cattle breeds, their deleterious mutation load can vary. We investigated this question by using whole-genome data from 432 animals belonging to 54 worldwide cattle breeds. Our analysis revealed a negative correlation between genomic heterozygosity and nonsynonymous-to-silent diversity ratio, which suggests a higher proportion of single nucleotide variants (SNVs) affecting proteins in low-diversity breeds. Our results also showed that low-diversity breeds had a larger number of high-frequency (derived allele frequency (DAF) > 0.51) deleterious SNVs than high-diversity breeds. An opposite trend was observed for the low-frequency (DAF ≤ 0.51) deleterious SNVs. Overall, the number of high-frequency deleterious SNVs was larger in the genomes of taurine cattle breeds than of indicine breeds, whereas the number of low-frequency deleterious SNVs was larger in the genomes of indicine cattle than in those of taurine cattle. Furthermore, we observed significant variation in the counts of deleterious SNVs within taurine breeds. The variations in deleterious mutation load between taurine and indicine breeds could be attributed to the population sizes of the wild progenitors before domestication, whereas the variations observed within taurine breeds could be due to differences in inbreeding level, strength of artificial selection, and/or founding population size. Our findings imply that the incidence of genetic diseases can vary between cattle breeds.
Tailored graphical lasso for data integration in gene network reconstruction
Authors: Lingjærde Camilla , Lien Tonje G. , Borgan Ørnulf , Bergholtz Helga , Glad Ingrid K. 
Published: October 2021

Abstract
Background
Identifying gene interactions is a topic of great importance in genomics, and approaches based on network models provide a powerful tool for studying these. Assuming a Gaussian graphical model, a gene association network may be estimated from multiomic data based on the non-zero entries of the inverse covariance matrix. Inferring such biological networks is challenging because of the high dimensionality of the problem, making traditional estimators unsuitable. The graphical lasso is constructed for the estimation of sparse inverse covariance matrices in such situations, using $$L_1$$

L
1

-penalization on the matrix entries. The weighted graphical lasso is an extension in which prior biological information from other sources is integrated into the model. There are however issues with this approach, as it naïvely forces the prior information into the network estimation, even if it is misleading or does not agree with the data at hand. Further, if an associated network based on other data is used as the prior, the method often fails to utilize the information effectively.

Results
We propose a novel graphical lasso approach, the tailored graphical lasso, that aims to handle prior information of unknown accuracy more effectively. We provide an R package implementing the method, . Applying the method to both simulated and real multiomic data sets, we find that it outperforms the unweighted and weighted graphical lasso in terms of all performance measures we consider. In fact, the graphical lasso and weighted graphical lasso can be considered special cases of the tailored graphical lasso, and a parameter determined by the data measures the usefulness of the prior information. We also find that among a larger set of methods, the tailored graphical is the most suitable for network inference from high-dimensional data with prior information of unknown accuracy. With our method, mRNA data are demonstrated to provide highly useful prior information for protein–protein interaction networks.

Conclusions
The method we introduce utilizes useful prior information more effectively without involving any risk of loss of accuracy should the prior information be misleading.