bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scientific and technological activities of TNC: current trends and prospects
Authors: Bezrukova Nataliia , Svichkar Vitalii , Solohub Ruslan 
Published: January 2021

In the article the authors consider the features of scientific and technological activities of transnational corporations, highlight the main trends and prospects for its development. In particular, it is emphasized that the source of modern development of society and human activity is innovation, and accordingly innovation becomes an important tool for all radical changes in human development and the economic system in general. Scientific and technological development of transnational corporations is a crucial prerequisite for ensuring their profitable activities. The purpose of the article is to analyze current trends and prospects for the development of scientific and technological activities of transnational corporations. The article examines the features of the R & D organization in multinational corporations. The dynamics of expenditures in individual leading TNCs on R&D is given. It is noted that the global nature of competition not only makes innovations more significant for TNCs, but also necessitates the search for new ways to innovate. The paper identifies the main types of technological policy, identifies the reasons for the centralization and decentralization of R & D, as well as possible risks that arise in the implementation of these policies. The experience of developed countries shows that competitiveness is ensured by a number of conditions, the main of which are the accumulated scientific and technological potential, institutional factors of technological progress and the presence of large knowledge-intensive corporations. Therefore, the current trend of scientific and technological activities of TNCs is a new wave of mergers and acquisitions (M&A). The authors present the largest mergers and acquisitions at the beginning of the XXI century. In the last two decades, as a result of the growing internationalization of research, the trend of forming strategic alliances has sharply increased, especially due to the merger of companies in such high-tech industries as pharmaceuticals, telecommunications, semiconductors, etc. Special attention is paid to analysis of the reasons for the formation of strategic alliances. It is shown that in some cases competitors become partners in strategic alliances in high-tech industries. In conclusion, it is noted that in conditions of fierce competition in both international and domestic markets, the ability of companies to operate and develop depends on their ability to create and implement innovations. It is innovations that cause continuous economic change, contribute to the dynamic development and increase the efficiency of both the economic system as a whole and individual enterprise. The scientific and technological development of corporations is the main prerequisite for ensuring and increasing their international competitiveness.
IN SILICO STUDY OF CEPHALOSPORIN DERIVATIVES TO INHIBIT THE ACTIONS OF Pseudomonas aeruginosa
Authors: Aprilian Saly Amaliacahya , Firdayani Firdayani , Kusumaningrum Susi 
Published: January 2021

Studi In Silico Senyawa Turunan Sefalosporin dalam Menghambat Aktivitas Bakteri Pseudomonas aeruginosa
Infeksi yang diakibatkan oleh bakteri gram-negatif, seperti Pseudomonas aeruginosa telah menyebar luas di seluruh dunia. Hal ini menjadi ancaman terhadap kesehatan masyarakat karena merupakan bakteri yang multi-drug resistance dan sulit diobati. Oleh karena itu, pentingnya pengembangan agen antimikroba untuk mengobati infeksi semakin meningkat dan salah satu yang saat ini banyak dikembangkan adalah senyawa turunan sefalosporin. Penelitian ini melakukan studi mengenai interaksi tiga dimensi (3D) antara antibiotik dari senyawa turunan Sefalosporin dengan penicillin-binding proteins (PBPs) pada P. aeruginosa. Tujuan dari penelitian ini adalah untuk mengklarifikasi bahwa agen antimikroba yang berasal dari senyawa turunan sefalosporin efektif untuk menghambat aktivitas bakteri P. aeruginosa. Struktur PBPs didapatkan dari Protein Data Bank (PDB ID: 5DF9). Sketsa struktur turunan sefalosporin digambar menggunakan Marvins Sketch. Kemudian, studi mengenai interaksi antara antibiotik dan PBPs dilakukan menggunakan program Mollegro Virtual Docker 6.0. Hasil yang didapatkan yaitu nilai rerank score terendah dari kelima generasi sefalosporin, di antaranya sefalotin (-116.306), sefotetan (-133.605), sefoperazon (-160.805), sefpirom (-144.045), dan seftarolin fosamil (-146.398).
Infections caused by gram-negative bacteria, such as Pseudomonas aeruginosa, have been spreading worldwide. It is a threat to public health because of its multi-drug resistance and difficulty to treat. Therefore, the demand for developing antimicrobial agents to treat infections is increasing. One of them that is currently under development is cephalosporin derivative compounds. This research studied the three-dimensional (3D) interaction between antibiotics from cephalosporin derivatives and penicillin-binding proteins (PBPs) in P. aeruginosa. This study aimed to clarify whether the cephalosporin derivatives were effective in inhibiting the activity of P. aeruginosa. The PBPs structure was obtained from the Protein Data Bank (PDB ID: 5DF9). The structural sketch of the cephalosporin derivative was drawn using the Marvins Sketch, whereas the study on the interaction between antibiotics and PBPs was carried out using the Mollegro Virtual Docker 6.0 program. The results showed the lowest rerank score from five cephalosporin derivatives, namely cephalotin (-116,306), cephotetan (-133.605), cephoperazone (-160.805), cephpirome (-144.045), and cephtaroline fosamil (-146.398).
Biomorphological and useful agronomic traits of the hexaploid winter triticale cultivar ‘Bilinda’ approved for cultivation in the Northwestern Region of the Russian Federation
Authors: Bekish L. P. , Uspenskaja V. A. , Peneva T. I. , Chikida N. N. 
Published: January 2021

A priority of agricultural production for the Northwest of Russia is to develop and introduce winter-hardy and productive cultivars of small grain forage crops, such as winter triticale, capable of producing high yields of grain and green biomass.‘Bilinda’, a new promising tetraploid winter triticale cultivar grown for grain forage, was studied from 2004 through 2019 at Leningrad Research Institute for Agriculture “Belogorka”. The data of the State Variety Trials (2017–2019) were also taken into account. Conventional techniques were used in the experiments, phenological observations, field and laboratory evaluation tests, and statistical data processing. Electrophoresis of gliadin in the grain of cv. ‘Bilinda’ and its registration as a “protein formula” were performed using the technique developed and approbated by the Molecular Biology Dept. of VIR. The hexaploid winter triticale cultivar ‘Kornet’ (k-3636) served as the reference. Cv. ‘Bilinda’ was developed using individual and mass selection of genotypes with recessive control of the ear’s morphological characters, which resulted in producing a homogeneous population with high yield potential and large plump grains. On average across the testing period, cv. ‘Bilinda’ significantly exceeded the reference ‘Kornet’ in grain yield (+1.04 t/ha), number of grains per ear (+32.3 pcs), and 1000 grain weight (+7.7 g), and in addition demonstrated higher winter hardiness than the reference (up to 98%). Under epiphytotic incidence of Septoria leaf blotch, the tested cultivar manifested a high level of resistance (scoring 7–9 points). ‘Bilinda’ is among high-yielding cultivars resistant to most leaf diseases. In 2020, this cultivar was approved for cultivation in the Northwestern Region (2) of Russia. Applying the method of variety identification based on the electrophoretic spectra of gliadin, a storage protein in grain, a protein “passport” was produced to ensure monitoring of the cultivar’s integrity and authenticity.
Identification of “bottlenecks” in the systems of adaptability in peach cultivars to specific abiotic factors limiting plant growth and development and affecting individual phases of ontogenesis to develop optimal algorithms for further breeding
Authors: Dragavtseva I. A. , Dragavtsev V. A. , Kuznetsova A. P. , Klyukina A. V. 
Published: January 2021

Modern breeding, especially when fruit plants cultivated for decades at the same location are concerned, requires a new strategy to develop cultivars resistant to abiotic limfactors of the environment. A more in-depth analysis of genotype–environment interaction phenomena is needed, as modern studies have shown that the level of plant productivity and yields is determined not by specific “genes of quantitative traits”, but mainly by the emergent (newly occurring when a lim-factor of the environment changes at the ontogenetic and phytocenotic levels) effects of the genotype–environment interaction (GEI). New knowledge is needed about the values of contributions to the productivity of a cultivar made by each of the genetic–physiological systems of plant adaptability (GPS-ad) when exposed to a particular lim-factor of the environment at a particular phase of ontogenesis. For the first time, aiming at finding promising peach genotypes for further breeding, we studied their adaptability to low temperatures in different horticulture zones of Krasnodar Territory.Shifts in the effects of low-temperature environmental stressors in the developmental phases of cultivars (produced by climate change) were analyzed in the time interval of 1985–2018.The presence of hereditary adaptive reserves for increasing peach productivity for each phase of development in the process of studying the phenomena of GEI was disclosed. Recommendations are given to breeders on phase-to-phase breeding of future cultivars: how to protect their production process at each developmental phase from negative effects of low temperatures.
Development of the adaptive spring bread wheat cultivar ‘Omskaya Yubileynaya’ under the conditions of the Siberian region
Authors: Popolzukhina N. A. , Popolzukhin P. V. , Gaidar A. A. , Parshutkin Yu. Yu. , Yakunina N. A. 
Published: January 2021

Background. As reported by the Russian Federal State Statistics Service, spring bread wheat planting acreage in 2019 reached 48% (28 million ha) of the total crop area in Russia. About 20% (5.4 million ha) of spring wheat was cultivated in the Siberian region. This is the reason why the region plays an important role in wheat cultivation, and the development of highly efficient cultivars adapted to Siberian environments is one of the prioritized tasks in the efforts to obtain sustainable spring bread wheat harvests.Materials and methods. Mutants and mutant × cultivar hybrids were used as parent material for top crossing. A decision was taken to apply multifold individual selection in accordance with the composition of agronomic traits in the mutant × cultivar hybrid population Lutescens 3 × [F5 B1 (Mutant 777 × G7251/03) × G7251/03] × Rosinka 3 (Mutant 112 × Irtyshanka 10) with backcrossing. In 2001–2016, expe rimental work was conducted at Omsk Agrarian Scientific Centre. Environmental testing was carried out at the Stepnoy Experiment Station (the steppe zone of Omsk Province) and the A.I. Barayev Research and Production Centre for Grain Farming (Northern Kazakhstan). The experiments and observations were performed in accordance with the techniques recommended by the State Commission for Crop Variety Trials.Results. The research showed that cv. ‘Omskaya Yubileynaya’ was characterized by resistance to lodging and to major plant diseases. It exceeded the reference in grain yield both in fallow (+0,50 t/ha) and nonfallow lands (+0,58 t/ha). The distinguishing feature of this cultivar was its large grain of high quality.Conclusions. During the development of cv. ‘Omskaya Yubileynaya’, the data were obtained that justified its prospective cultivation within the steppe and forest-steppe zones of Siberia and Kazakhstan. The cultivar has been registered in the national lists of breeding achievements since 2019.
The role of Prunus cerasifera Ehrh. in the origin, evolution and improvement of stone fruit cultivars
Authors: Eremin G. V. 
Published: January 2021

At Krymsk Experiment Breeding Station of VIR, as a result of collecting, studying, and selective use of myrobalan plum genetic diversity, the intraspecific taxonomy of the species Prunus cerasifera Ehrh. was clarified. Donors of traits significant for breeding were identified and, with their use, adaptable cultivars of myrobalan plum, Russian plum and clonal rootstocks of stone fruit plants were developed.Intraspecific classification of P. cerasifera is proposed, with the identified subspecies:subsp. cerasifera (typical myrobalan plum);subsp. orientalis (M. Pop.) Erem. et Garcov. (Oriental myrobalan plum);and subsp. macrocarpa Erem. et Garcov. (large-fruited myrobalan plum).Within subsp. P. cerasifera subsp. macrocarpa, varieties were identified:var. macrocarpa (typical, or Krymsk);var. georgica Erem. et Garcov. (Georgian);var. iranica (Koval.) Erem. et Garcov. (Iranian);var. nairica (Koval.) Erem. et Garcov. (Armenian);var. pissardii Carr. (Pissard);and var. taurica (Kost.) Erem. et Garcov. (Taurida).The participation of myrobalan plum in the origin of spp. P. brigantiaca Vill., P. cocomilia Tem., and P. spinosa L. was traced. Involvement of large-fruited myrobalan plum in hybridization with blackthorn contributed to the manifestation of an exceptional polymorphism among the varieties of the hybridogenic species P. domestica L. (P. cerasifera × P. spinosa). As a result of hybridization between myrobalan plum and Chinese plum varieties, a new cultigen species emerged – Russian plum (× P. rossica Erem.). By now, 127 cultivars of this species and 7 clonal rootstocks for stone fruit crops have been developed. These cultivars and clonal rootstocks are zoned for Russia and a number of other countries.
Adaptive potential of durum wheat (Triticum durum Desf.) varieties of Azerbaijan
Authors: Rustamov Kh. N. , Akparov Z. I. , Abbasov M. A. 
Published: January 2021

Background. Studies into the adaptability of the genetic diversity of cultivated plants and their wild relatives to various environments are induced by global climate change. Introduction of adaptive wheat cultivars resistant to environmental stressors is the basis for stable harvests. This article presents the results of a research into the adaptive value of indigenous durum wheat varieties and improved cultivars released in different years in Azerbaijan.Materials and methods. The experiments were carried out in the foothills of Mountainous Shirvan under unsecured non-irrigation at Gobustan Experiment Station of the Research Institute of Crop Husbandry. In 2012–2014, contrasting in weather conditions, levels and structure of yield were analyzed. VIR’s guidelines were used to study 42 durum wheat varie ties, including 10 landraces. The years of study differed sharply in rainfall. Selyaninov’s hydrothermal coefficient was used to assess the conditions of growing seasons.Results. Mostly modern cultivars of the semi-intensive type were distinguished for a set of agrobiological traits. Adaptability coefficients (0.81–1.23) showed that the response of the studied varieties to unfavorable conditions was highly expressed. Indigenous landraces ‘Ag bughda’ and ‘Bozak’, old breeding varieties ‘Arandani’, ‘Ag bughda 13’, ‘Kahraba’ and ‘Mirbashir 50’, and new cultivars ‘Karagilchig 2’ and ‘Barakatli 95’ had the highest adaptability coefficients. The first of them demonstrated stable yield, and the latter two were also resistant to stressors.Conclusion. Durum wheat yields under the conditions of moderately continental climate in Mountainous Shirvan depended on the number and weight of grains per ear. The varieties identified for the best adaptability are recommended to be included in crosses to develop new plastic cultivars of durum wheat.
Source material for breeding winter bread wheat in the north of the Middle Volga region
Authors: Fadeeva I. D. , Gazizov I. N. , Khakimov A. G. , Mitrofanova O. P. 
Published: January 2021

Background. Bread wheat (Triticum aestivum L.), due to significant progress in breeding, has high potential of biological productivity, but its implementation is quite low. To change the situation for the better, it is necessary to increase the resistance of developed cultivars to unfavorable abiotic and biotic factors in the regions of its cultivation. To solve this problem, source material is required. The purpose of this research was to evaluate a set of winter wheat accessions from the VIR collection, and first of all, the newly introduced accessions, and the accessions from the working collection of Kazan Scientific Center of the Russian Academy of Sciences for variability of agronomic traits and stability under the conditions of the north of the Middle Volga region, and to identify sources promising for inclusion in the crossing programs.Materials and methods. A three-year field study of 166 winter bread wheat accessions was carried out. All accessions were assessed for their overwintering and plant and ear productivity traits using the methods developed by VIR and the State Variety Trials. The best accessions, or sources, were selected by comparing them with the reference cv. ‘Kazan 560’, taking into account the quantitative values of such indicators as “general adaptability” (ОАСi ), variance of “specific adaptability” (σ2САСi ) and “relative stability” (Sgi) for each accession according to A. V. Kilchevsky and L. V. Khotyleva.Results and conclusion. Descriptions of winter bread wheat accessions are presented in the context of their agronomic traits. Groups and subgroups of accessions with different trait variability levels were identified. Some accessions with stable levels of trait manifestation exceeded the reference in ear productivity. All of them are promising for wheat breeding programs. It is shown that the group of accessions “weakly changing” over the years of study differs from the group of “moderately/strongly changing” accessions in values of correlations between traits and the number of significant correlations.
Developing donors of ultra-early maturity in barley
Authors: Zveinek I. A. , Kovaleva O. N. 
Published: January 2021

Background. The length of the growing season is a limiting factor in many regions with unstable climatic conditions. The development of ultra-early barley donors makes it possible to accelerate the breeding process aimed at producing commercial cultivars adapted to cultivation area requirements.Materials and methods. The donors Kibel, Kibel uluchshenny, Kibtsel and Kibkor were obtained through individual selection of barley forms combining earliness and productivity from the hybrid combination Belogorsky × k-15881. The experiments were carried out according to the approved guidelines. Yield components were used to calculate the index of productivity for the donors versus the reference cv. ‘Belogorsky’.Results and conclusions. Earliness is controlled in the donors by three recessive genes. The donors’ period from emergence to heading was 7–9 days shorter than that of the reference cv. ‘Belogorsky’, with a low norm of reaction, which attested to their high adaptability. The resulting barley forms were highly resistant to lodging. The donor Kibel uluchshenny in all spike yield components did not differ from the reference. The other donors were close to the reference in spike length and 1000 seed weight. The example of Kibel uluchshenny was used to demonstrate the possibility of producing barley forms combining high earliness and good productivity. The developed donors may prove useful in the breeding for earliness in the areas where the length of the growing season is a limiting factor.
ESTATUTO INTERNACIONAL DE REPRODUÇÃO ASSISTIDA: UMA INTERVENÇÃO NECESSÁRIA?
Authors: Cidrão Taís Vasconcelos , Muniz Antônio Walber , Vieira Pollyana Souza 
Published: January 2021

O estudo tem como objetivo analisar a necessidade de elaboração, pelos Estados, de Tratado Internacional sobre Reprodução Assistida. O interesse na pesquisa parte de um estudo em que se constatou que a diversidade cultural, social e religiosa exercem influência significativa na legislação de cada país. Soma-se a esse fato a facilidade de acesso a outros Estados para utilização de técnicas proibida no país de origem. Muito embora se tenha conhecimento desses fatores, não há uma normatização global sobre o tema, o que contribui para a existência de um vácuo legislativo na disciplina internacional, fato que tem contribuído para o aumento da insegurança jurídica advinda da prática da atividade. Portanto, importância é um estudo sobre a necessidade de elaboração de um Tratado Internacional que contenha regras basilares e uniformes sobre a matéria Reprodução Assistida. Para tanto, parte-se de uma análise documental do Relatório trienal da Internacional Federation of Fertility Societies, (IFFS), de dados publicados pela Agência de Vigilância Sanitária (ANVISA) sobre a importação de gametas humanos, bem como análise da legislação e jurisprudência internacional sobre o tema.
ANÁLISE DAS ESCOLAS CLÁSSICA E POSITIVISTA À LUZ DO LIVRO CRIMINOLOGIA CRÍTICA E CRÍTICA DO DIREITO PENAL DE ALESSANDRO BARATTA
Authors: Costa Débora Laís dos Santos , Silva Filho Edson Vieira 
Published: January 2021

O trabalho utiliza como base o livro Criminologia Crítica e Crítica do Direito Penal de Alessandro Baratta, para realizar uma pesquisa quanto as Escolas Clássica e Positivista, analisando suas divergências e convergências. Ambas têm como finalidade a sanção daqueles indivíduos que não se enquadram no pacto social de harmonia da comunidade. Com isso em mente, o artigo tem como objetivo relacionar as teorias psicanalistas de Freud, tal como é tratado no livro base de Baratta, com a superação, ou não, da Escola Positivista, isto pois, esta tem um viés determinista quanto a qualidade dos delinquentes, ou seja, esta Escola utiliza o entendimento de clientela preferencial do Direito Penal. O objetivo especifico apresenta-se nas pesquisas quanto ambas as escolas; as teorias psicanalistas de Freud – comportamento delituoso e sociedade punitiva –, as quais englobam os conceitos de Id, Ego e Superego; e, realizar a conexão entre tais teorias e a Escola Positivista. Para que seja realizado o trabalho utilizou-se do método interpretativo analítico da bibliografia original do autor, entremeando-a com obras contemporâneas.