bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferric maltol Real-world Effectiveness Study in Hospital practice (FRESH): clinical characteristics and outcomes of patients with inflammatory bowel disease receiving ferric maltol for iron-deficiency anaemia in the UK
Authors: Cummings JR Fraser , Fraser Aileen , Stansfield Catherine , Beales Ian , Sebastian Shaji , Hoque Sami 
Published: February 2021

ObjectiveTo assess outcomes in patients with iron-deficient inflammatory bowel disease (IBD) treated with ferric maltol in UK real-world practice.Design/MethodThis observational, multicentre, retrospective cohort study included adults with IBD and iron-deficiency anaemia (IDA; haemoglobin ≥95 to <120 g/L (women) or ≥95 to <130 g/L (men) plus serum ferritin <30 µg/L or transferrin saturation <20%) who received ferric maltol. Data were extracted from patient records. The primary analysis was the proportion of patients with normalised haemoglobin (≥120 g/L (women); ≥130 g/L (men)) over 12 weeks. Iron indices and safety were assessed.ResultsThirty of 59 patients had data for the primary outcome, 19 of whom (63%) achieved haemoglobin normalisation at week 12. Mean±SD haemoglobin was 127±16 g/L at week 12 (increase of 14±17 g/L from baseline). Overall, 27 patients achieved haemoglobin normalisation by the end of the observation period; mean±SD time to normalisation was 49.5±25.6 days. Nine of 17 patients had normalised serum ferritin (30–300 µg/L) at week 12, and 16 patients had normalised ferritin at the end of the observation period; mean±SD time to normalisation was 71.3±27.6 days. Twenty-four adverse events occurred in 19 patients (32%); most frequent adverse events were abdominal pain or discomfort (n=9) and constipation (n=3).ConclusionFerric maltol increases haemoglobin and iron indices and is generally well tolerated in patients with IBD and IDA treated in clinical practice. These real-world data support findings from randomised controlled trials.
Reactions to and explanations for the birth of a baby with albinism: a qualitative study in Busoga, Uganda
Authors: Taylor Julie , Bradbury-Jones C , Ogik Peter , Kawuma Fazira , Betts Jane , Lund Patricia 
Published: February 2021

ObjectivesBabies born with the genetic condition albinism lack pigment in their hair, skin and eyes due to compromised melanin production. This leads to poor vision and the risk of early death due to skin cancer. In Uganda, one of the least developed countries in the world, their lack of pigmentation makes them very different in appearance within their communities. Local explanations of albinism include links to witchcraft and the supernatural. We aimed to explore reactions to the birth of a baby with albinism in Uganda.DesignSecondary analysis of birth stories derived from qualitative interviews and focus group discussions in sharing circles.SettingInterviews took place in the Busoga subregion (kingdom) in the eastern part of Uganda.ParticipantsSeventy-three (73) participants took part in eight sharing circles (n=56) and 17 individual interviews. Participants included people with albinism, parents of people with albinism and a range of other interested parties, including local leaders and teachers.ResultsReactions were generally those of shock and rejection, although cases of acceptance were also recorded. The varied explanations given to account for this unexpected event included accounts involving witchcraft, ghosts, animal familiars and religion, as well as genetics. In a framework surmising that someone must possess a dark skin to be intrinsically valued in African societies a baby with albinism does not fulfil this requirement of ‘personhood’. The mother was often blamed for having produced some ‘thing’ that is not a proper person.ConclusionsWe argue that a biomedical explanation, although unlikely to displace other understandings, helps to establish a baby with albinism as a real person with a genetic difference, and hence fosters greater acceptance.
Implementation of medicines pricing policies in sub-Saharan Africa: protocol for a systematic review
Authors: Mirzoev Tolib , Koduah Augustina , Cronin de Chavez Anna , Baatiema Leonard , Danso-Appiah Anthony , Ensor Tim , Agyepong Irene Akua , Wright Judy M , Kretchy Irene A , King Natalie 
Published: February 2021

IntroductionEnsuring universal availability and accessibility of medicines and supplies is critical for national health systems to equitably address population health needs. In sub-Saharan Africa (SSA), this is a recognised priority with multiple medicines pricing policies enacted. However, medicine prices have remained high, continue to rise and constrain their accessibility. In this systematic review, we aim to identify and analyse experiences of implementation of medicines pricing policies in SSA. Our ambition is for this evidence to contribute to improved implementation of medicines pricing policies in SSA.Methods and analysisWe will search: Medline, Web of Science, Scopus, Global Health, Embase, Cairn.Info International Edition, Erudit and African Index Medicus, the grey literature and reference from related publications. The searches will be limited to literature published from the year 2000 onwards that is, since the start of the Millennium Development Goals.Published peer-reviewed studies of implementation of medicines pricing policies in SSA will be eligible for inclusion. Broader policy analyses and documented experiences of implementation of other health policies will be excluded. The team will collaboratively screen titles and abstracts, then two reviewers will independently screen full texts, extract data and assess quality of the included studies. Disagreements will be resolved by discussion or a third reviewer. Data will be extracted on approaches used for policy implementation, actors involved, evidence used in decision making and key contextual influences on policy implementation. A narrative approach will be used to synthesise the data. Reporting will be informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guideline.Ethics and disseminationNo ethics approvals are required for systematic reviews.Results will be disseminated through academic publications, policy briefs and presentations to national policymakers in Ghana and mode widely across countries in SSA.PROSPERO registration numberCRD42020178166.
Covidogram as a simple tool for predicting severe course of COVID-19: population-based study
Authors: Jarkovsky Jiri , Benesova Klara , Cerny Vladimir , Razova Jarmila , Kala Petr , Dolina Jiri , Majek Ondrej , Sebestova Silvie , Bezdekova Monika , Melicharova Hana , Snajdrova Lenka , Dusek Ladislav , Parenica Jiri 
Published: February 2021

ObjectivesCOVID-19 might either be entirely asymptomatic or manifest itself with a large variability of disease severity. It is beneficial to identify early patients with a high risk of severe course. The aim of the analysis was to develop a prognostic model for the prediction of the severe course of acute respiratory infection.DesignA population-based study.SettingCzech Republic.ParticipantsThe first 7455 consecutive patients with COVID-19 who were identified by reverse transcription-PCR testing from 1 March 2020 to 17 May 2020.Primary outcomeSevere course of COVID-19.ResultOf a total 6.2% of patients developed a severe course of COVID-19. Age, male sex, chronic kidney disease, chronic obstructive pulmonary disease, recent history of cancer, chronic heart failure, acid-related disorders treated with proton-pump inhibitors and diabetes mellitus were found to be independent negative prognostic factors (Area under the ROC Curve (AUC) was 0.893). The results were visualised by risk heat maps, and we called this diagram a ‘covidogram’. Acid-related disorders treated with proton-pump inhibitors might represent a negative prognostic factor.ConclusionWe developed a very simple prediction model called ‘covidogram’, which is based on elementary independent variables (age, male sex and the presence of several chronic diseases) and represents a tool that makes it possible to identify—with a high reliability—patients who are at risk of a severe course of COVID-19. Obtained results open clinically relevant question about the role of acid-related disorders treated by proton-pump inhibitors as predictor for severe course of COVID-19.
Association between the COVID-19 pandemic and the risk for adverse pregnancy outcomes: a cohort study
Authors: Du Min , Yang Jie , Han Na , Liu Min , Liu Jue 
Published: February 2021

ObjectivesThe secondary impacts of the COVID-19 pandemic on adverse maternal and neonatal outcomes remain unclear. In this study, we aimed to evaluate the association between the COVID-19 pandemic and the risk for adverse pregnancy outcomes.DesignWe conduced retrospective analyses on two cohorts comprising 7699 pregnant women in Beijing, China, and compared pregnancy outcomes between the pre-COVID-2019 cohort (women who delivered from 20 May 2019 to 30 November 2019) and the COVID-2019 cohort (women who delivered from 20 January 2020 to 31 July 2020). The secondary impacts of the COVID-2019 pandemic on pregnancy outcomes were assessed by using multivariate log-binomial regression models, and we used interrupted time-series (ITS) regression analysis to further control the effects of time-trends.SettingOne tertiary-level centre in Beijing, ChinaParticipants7699 pregnant women.ResultsCompared with women in the pre-COVID-19 pandemic group, pregnant women during the COVID-2019 pandemic were more likely to be of advanced age, exhibit insufficient or excessive gestational weight gain and show a family history of chronic disease (all p<0.05). After controlling for other confounding factors, the risk of premature rupture of membranes and foetal distress was increased by 11% (95% CI, 1.04 to 1.18; p<0.01) and 14% (95% CI, 1.01 to 1.29; p<0.05), respectively, during the COVID-2019 pandemic. The association still remained in the ITS analysis after additionally controlling for time-trends (all p<0.01). We uncovered no other associations between the COVID-19 pandemic and other pregnancy outcomes (p>0.05).ConclusionsDuring the COVID-19 pandemic, more women manifested either insufficient or excessive gestational weight gain; and the risk of premature rupture of membranes and foetal distress was also higher during the pandemic.
Benefit of psychiatric evaluation on anxiety in patients with Charles Bonnet syndrome
Authors: Doeller Birgit , Kratochwil Martin , Sifari Lena , Hirnschall Nino , Findl Oliver 
Published: February 2021

ObjectiveCharles Bonnet syndrome (CBS) is defined as an occurrence of visual hallucinations (VHs) in the absence of any psychiatric/neurological disorder. Significantly reduced vision due to age-related macular degeneration (AMD), cataract or glaucoma is the most common cause for CBS. Aim of this randomized controlled study was to assess whether additional treatment by a psychiatrist is beneficial for patients with CBS.Methods and AnalysisPatients with visual acuity of 0.5 LogMAR or worse in the better eye were screened. Instruments used were an interview asking about details of the VH, a mental test and a questionnaire on quality of life. Patients with CBS were randomised into two groups: in group 1, a patient-doctor consultation was performed by an ophthalmologist, and in group 2 a consultation and, if needed, additional medical assessment and treatment was given by a psychiatrist.Results4900 patients were screened. 390 patients met the inclusion criteria and among these a CBS prevalence of 34 patients (8.7%) was found. The female-to-male ratio was 4:1 and the average age was 79.3 ± 9.7 years. Four different types of VH were observed:41% humans (n=14), 32% geometrical shapes/patterns (n=11), 15% plants (n=5) and 12% animals (n=4). The change in quality of life in patients with CBS was not significantly different in both groups (p=0.727, ophthalmologist: n=18, psychiatrist: n=16).ConclusionIt is essential for medical staff involved with patients suffering from severe vision loss to be aware of CBS. This will help to better identify and interpret symptoms and could also lead to a more adequate treatment for affected patients.DiscussionIt is essential for medical staff involved with patients suffering from severe vision loss to be aware of CBS. This will help to better identify and interpret symptoms and could also lead to a more adequate treatment for affected patients.
Socioeconomic risk factors and age-related macular degeneration in the UK Biobank study
Authors: Yip Jennifer Lai Yee , Muthy Zaynah , Peto Tunde , Lotery Andrew , Foster Paul J , Patel Praveen 
Published: February 2021

ObjectiveThere is contrasting evidence on the relationship between socioeconomic status (SES) and age-related macular degeneration (AMD), the most common cause of visual impairment (VI) in developed countries. This study examines the relationship between SES, cardiovascular risk factors and self-reported AMD.Methods and analysisOver 500000 people participated in the UK Biobank study from 2006 to 2019, with sociodemographic data and clinical measurements collected using standardised procedures. Visual acuity was measured in 117907 participants with VI defined as LogMAR ≤0.3. We used logistic regression to examine the cross-sectional associations between SES and self-reported AMD.ResultsSelf-reported AMD was available for 133339 participants aged 50 and older. People reporting AMD had higher academic qualifications, lower income, were unable to work due to disability, have higher BMI, diabetes and vascular heart disease after adjusting for age and sex. In a multivariable analysis, higher income was protective of AMD and economic inactivity due to disability increased the odds of AMD (2.02, 95% CI 1.13 to 3.61). Both associations were independent of cardiovascular factors, but was no longer significant after adjusting for VI.ConclusionsThe association between education, employment and household income with AMD was independent of cardiovascular risk factors.
Control of large helium cryogenic systems: a case study on CERN LHC
Authors: Pezzetti Marco 
Published: February 2021

AbstractThe CERN cryogenic facilities demand a versatile, distributed, homogeneous and highly reliable control system. For this purpose, CERN conceived and developed several frameworks (JCOP, UNICOS, FESA, CMW), based on current industrial technologies and COTS equipment, such as PC, PLC and SCADA systems complying with the requested constraints. The cryogenic control system nowadays uses these frameworks and allows the joint development of supervision and control layers by defining a common structure for specifications and code documentation. Another important advantage of the CERN frameworks is the possibility to integrate different control systems into a large technical system with communication capability. Such a system is capable of sharing control variables from all accelerator apparatus in order to cope with the operation scenarios.The first implementation of this control architecture started in 2000 for the Large Hadron Collider (LHC). Since then CERN continued developing the hardware and software components of the cryogenic control system, based on the exploitation of the experience gained. These developments are always aimed at increasing the safety and improving the performance. To overcome the long-term maintenance challenges, key strategies such as the use of homogeneous hardware solutions and the optimization of the maintenance procedures were set up. They are easing the development of the control applications and the hardware configuration by allowing a structured and homogeneous approach. Furthermore, they reduce the needed manpower and minimize the financial impact of the periodical maintenance. In that context, the standardization of technical solutions both at hardware and software level simplify also the systems monitoring the operation and maintenance processes, while providing a high level of availability.
Mantle convection and possible mantle plumes beneath Antarctica – insights from geodynamic models and implications for topography
Authors: Bredow Eva , Steinberger Bernhard , Gassmöller Rene , Dannberg Juliane 
Published: February 2021

Abstract
This chapter describes large-scale mantle flow structures beneath Antarctica as derived from global seismic tomography models of the present-day state. In combination with plate reconstructions, the time-dependent pattern of palaeosubduction can be simulated and is shown from the rarely seen Antarctic perspective. Furthermore, a dynamic topography model demonstrates which kind and scales of surface manifestations can be expected as a direct and observable result of mantle convection. The last section of this chapter features an overview of the classical concept of deep-mantle plumes from a geodynamic point of view and how recent insights, mostly from seismic tomography, have changed the understanding of plume structures and dynamics over past decades. The long-standing and controversial hypothesis of a mantle plume beneath West Antarctica is summarized and addressed with geodynamic models, which estimate the excess heat flow of a potential plume at the bedrock surface. However, the predicted heat flow is small, while differences in surface heat-flux estimates are large; therefore, the results are not conclusive with regard to the existence of a West Antarctic mantle plume. Finally, it is shown that global mantle flow would cause the tilting of whole-mantle plume conduits beneath West Antarctica such that their base is predicted to be displaced about 20° northward relative to the surface position, closer to the southern margin of the Pacific Large Low-Shear Velocity Province.
Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors
Authors: Wick Antje , Bähr Oliver , Schuler Martin , Rohrberg Kristoffer , Chawla Sant P. , Janku Filip , Schiff David , Heinemann Volker , Narita Yoshitaka , Lenz Heinz-Josef , Ikeda Masafumi , Ando Yuichi , Wick Wolfgang , Steinbach Joachim P. , Burger Michael C. , Wenger Katharina , Lassen Ulrik , Sankhala Kamalesh K. , Roggia Cristiana , Genvresse Isabelle , Munhoz Catya , Rentzsch Christine , Reschke Susanne , Langer Simon , Wagner Markus , Kaulfuss Stefan , Cai Charles , Lagkadinou Eleni , Jeffers Michael , Peña Carol , Tabatabai Ghazaleh 
Published: February 2021

Abstract

Purpose:
BAY1436032, an inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1), was active against multiple IDH1-R132X solid tumors in preclinical models. This first-in-human study was designed to determine the safety and pharmacokinetics of BAY1436032, and to evaluate its potential pharmacodynamics and antitumor effects.

Patients and Methods:
The study comprised of dose escalation and dose expansion cohorts. BAY1436032 tablets were orally administered twice daily on a continuous basis in subjects with mIDH1 solid tumors.

Results:
In dose escalation, 29 subjects with various tumor types were administered BAY1436032 across five doses (150–1,500 mg twice daily). BAY1432032 exhibited a relatively short half-life. Most evaluable subjects experienced target inhibition as indicated by a median maximal reduction of plasma R-2-hydroxyglutarate levels of 76%. BAY1436032 was well tolerated and an MTD was not identified. A dose of 1,500 mg twice daily was selected for dose expansion, where 52 subjects were treated in cohorts representing four different tumor types [lower grade glioma (LGG), glioblastoma, intrahepatic cholangiocarcinoma, and a basket cohort of other tumor types]. The best clinical outcomes were in subjects with LGG (n = 35), with an objective response rate of 11% (one complete response and three partial responses) and stable disease in 43%. As of August 2020, four of these subjects were in treatment for &gt;2 years and still ongoing. Objective responses were observed only in LGG.

Conclusions:
BAY1436032 was well tolerated and showed evidence of target inhibition and durable objective responses in a small subset of subjects with LGG.
Enhancement in data security and integrity using minhash technique
Authors: Abed Sa'ed , Waleed Lamis , Aldamkhi Ghadeer , Hadi Khaled 
Published: February 2021

Data <span>encryption process and key generation techniques protect sensitive data against any various attacks. This paper focuses on generating secured cipher keys to raise the level of security and the speed of the data integrity checking by using the MinHash function. The methodology is based on applying the cryptographic algorithms rivest-shamir-adleman (RSA) and advanced encryption standard (AES) to generate the cipher keys. These keys are used in the encryption/decryption process by utilizing the Pearson Hash and the MinHash techniques. The data is divided into shingles that are used in the Hash function to generate integers and in the MinHash function to generate the public and the private keys. MinHash technique is used to check the data integrity by comparing the sender’s and the receiver’s encrypted digest. The experimental results show that the RSA and AES algorithms based on the MinHash function have less encryption time compared to the normal hash functions by 17.35% and 43.93%, respectively. The data integrity between two large sets is improved by 100% against the original algorithm in terms of completion time, and 77% for small/medium data and 100% for large set data in terms of memory utilization.</span>
A new species of Neopsis (Hemiptera: Cicadellidae: Tartessinae), with new distribution records from Paraná State, Brazil
Authors: Domahovski Alexandre Cruz 
Published: February 2021

Neopsis campestris sp. nov. is described and illustrated based on male and female specimens collected on native grassland at the Guartelá State Park, Paraná State, Southern Brazil. New distribution records are presented for three previously known species, Neopsis aurea Takiya & Dietrich, 2017, Neopsis myrceugeniae Takiya & Dietrich, 2017 and Neopsis robusta Linnavuori, 1965, representing the first known records of the subfamily Tartessinae for Paraná State. A distribution map is also provided to illustrate the locality data of specimens studied herein.
Gender Differences in Publication Authorship During COVID‐19: A Bibliometric Analysis of High‐Impact Cardiology Journals
Authors: DeFilippis Ersilia M. , Sinnenberg Lauren , Mahmud Nadim , Wood Malissa J. , Hayes Sharonne N. , Michos Erin D. , Reza Nosheen 
Published: February 2021

Background
The purpose of this study was to examine gender differences in authorship of manuscripts in select high‐impact cardiology journals during the early coronavirus disease 2019 (COVID‐19) pandemic.

Methods and Results

All manuscripts published between March 1, 2019 to June 1, 2019 and March 1, 2020 to June 1, 2020 in 4 high‐impact cardiology journals (
Journal of the American College of Cardiology
,
Circulation
,
JAMA Cardiology
, and
European Heart Journal
) were identified using bibliometric data. Authors' genders were determined by matching first name with predicted gender using a validated multinational database (Genderize.io) and manual adjudication. Proportions of women and men first, co‐first, senior, and co‐senior authors, manuscript types, and whether the manuscript was COVID‐19 related were recorded. In 2019, women were first authors of 176 (22.3%) manuscripts and senior authors of 99 (15.0%) manuscripts. In 2020, women first authored 230 (27.4%) manuscripts and senior authored 138 (19.3%) manuscripts. Proportions of woman first and senior authors were significantly higher in 2020 compared with 2019. Women were more likely to be first authors if the manuscript's senior author was a woman (33.8% for woman first/woman senior versus 23.4% for woman first/man senior;
P
<0.001). Women were less likely to be first authors of COVID‐19‐related original research manuscripts (
P
=0.04).

Conclusions
Representation of women as key authors of manuscripts published in major cardiovascular journals increased during the early COVID‐19 pandemic compared with similar months in 2019. However, women were significantly less likely to be first authors of COVID‐19‐related original research manuscripts. Future investigation into the gender‐disparate impacts of COVID‐19 on academic careers is critical.