bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerating Hepatitis C virus elimination in Egypt by 2030: A national survey of communication for behavioral development as a modelling study
Authors: Metwally Ammal M. , Elmosalami Dalia M. , Elhariri Hazem , El Etreby Lobna A. , Aboulghate Ahmed , El-Sonbaty Marwa M. , Mohsen Amira , Saleh Rehan M. , Abdel-Latif Ghada A. , Samy Sahar , El Deeb Sherif E. , Fathy Asmaa M. , Salah Mohab M. , Abdel Mawla Mohamed A. , Imam Hanaa M. , Ibrahim Nihad A. , Shaaban Fatma A. , Elamir Reham Y. , Abdelrahman Mohamed , El-Sayed Manal H. 
Published: February 2021

Aim of the work
This study aimed at assessing the dominance of risk practices associated with HCV endemicity in Egypt and detecting the behavioral development level concerning different aspects of HCV risk behaviors with respect to age and gender. The survey highlights the most cost-effective strategies that could accelerate HCV elimination in Egypt.

Subjects and methods
A national household survey targeted 3780 individuals (age range: 10–85 years). The sample was a systematic probability proportionate to size from 6 governorates representing the six major subdivisions of Egypt. The indicators used for assessing the behavioral development level towards HCV included six domains: awareness (7 indicators), perceived risk (5 indicators), motivation with the intention to change (4 and 5 indicators for males and females respectively), trial, rejection or adoption (6 and 5 indicators for males and females respectively).

Results
The study revealed that along the continuum of behavior development, the percentage of the participants who acquired half of the scores was as follows: 73.1% aware, 69.8% developed perceived risk, 80.6% motivated with only 28.9% adopting the recommended behaviors, 32% rejected them, 2.3% were in the trial stage versus 35.8% who did not try any. Adolescents had significantly lower levels of development for almost all domains when compared to adults. Statistical higher significance was detected in favor of adults, employees, married, Lower Egypt governorates, and university-educated participants (p<0.001) regarding awareness, perceived risk, and motivation scores. More than half of the participants incorrectly believed that contaminated food, sharing food utilities, contaminated water, mosquitoes, and schistosomiasis would lead to HCV transmission.

Conclusion
Egypt would be closer to HCV elimination when cost-effective strategies are directed not towards creating awareness, perceived risk or motivation to change- (at an acceptable level)- but towards motivating adopting risk-reduction behaviors for HCV, tackling misconceptions and reinforcement of social support.
Development and validation of a prediction model for tocilizumab failure in hospitalized patients with SARS-CoV-2 infection
Authors: Mussini Cristina , Cozzi-Lepri Alessandro , Menozzi Marianna , Meschiari Marianna , Franceschini Erica , Milic Jovana , Brugioni Lucio , Pietrangelo Antonello , Girardis Massimo , Cossarizza Andrea , Tonelli Roberto , Clini Enrico , Massari Marco , Bartoletti Michele , Ferrari Anna , Cattelan Anna Maria , Zuccalà Paola , Lichtner Miriam , Rossotti Roberto , Girardi Enrico , Nicastri Emanuele , Puoti Massimo , Antinori Andrea , Viale Pierluigi , Guaraldi Giovanni 
Published: February 2021

Background
The aim of this secondary analysis of the TESEO cohort is to identify, early in the course of treatment with tocilizumab, factors associated with the risk of progressing to mechanical ventilation and death and develop a risk score to estimate the risk of this outcome according to patients’ profile.

Methods
Patients with COVID-19 severe pneumonia receiving standard of care + tocilizumab who were alive and free from mechanical ventilation at day 6 after treatment initiation were included in this retrospective, multicenter cohort study. Multivariable logistic regression models were built to identify predictors of mechanical ventilation or death by day-28 from treatment initiation and β-coefficients were used to develop a risk score. Secondary outcome was mortality. Patients with the same inclusion criteria as the derivation cohort from 3 independent hospitals were used as validation cohort.

Results
266 patients treated with tocilizumab were included. By day 28 of hospital follow-up post treatment initiation, 40 (15%) underwent mechanical ventilation or died [26 (10%)]. At multivariable analysis, sex, day-4 PaO2/FiO2 ratio, platelets and CRP were independently associated with the risk of developing the study outcomes and were used to generate the proposed risk score. The accuracy of the score in AUC was 0.80 and 0.70 in internal validation and test for the composite endpoint and 0.92 and 0.69 for death, respectively.

Conclusions
Our score could assist clinicians in identifying, early after tocilizumab administration, patients who are likely to progress to mechanical ventilation or death, so that they could be selected for eventual rescue therapies.
Prevalence and predictors of secondary traumatic stress symptoms in health care professionals working with trauma victims: A cross-sectional study
Authors: Ogińska-Bulik Nina , Gurowiec Piotr Jerzy , Michalska Paulina , Kędra Edyta 
Published: February 2021

Introduction
Medical personnel is an occupational group that is especially prone to secondary traumatic stress. The factors conditioning its occurrence include organizational and work-related factors, as well as personal features and traits. The aim of this study was to determine Secondary Traumatic Stress (STS) indicators in a group of medical personnel, considering occupational load, job satisfaction, social support, and cognitive processing of trauma.

Material and methods
Results obtained from 419 medical professionals, paramedics and nurses, were analyzed. The age of study participants ranged from 19 to 65 (M = 39.60, SD = 11.03). A questionnaire developed for this research including questions about occupational indicators as well as four standard evaluation tools: Secondary Traumatic Stress Inventory, Job Satisfaction Scale, Social Support Scale which measures four support sources (supervisors, coworkers, family, friends) and Cognitive Processing of Trauma Scale which allows to evaluate cognitive coping strategies (positive cognitive restructuring, downward comparison, resolution/acceptance, denial, regret) were used in the study.

Results
The results showed that the main predictor of STS symptoms in the studied group of medical personnel is job satisfaction. Two cognitive strategies also turned out to be predictors of STS, that is regret (positive relation) and resolution/acceptance (negative relation). The contribution of other analyzed variables, i.e., denial, workload and social support to explaining the dependent variable is rather small.

Conclusions
Paramedics and nurses are at the high risk of indirect traumatic exposure and thus may be more prone to secondary traumatic stress symptoms development. It is important to include the medical personnel in the actions aiming at prevention and reduction of STS symptoms.
Berberine ameliorates vascular dysfunction by a global modulation of lncRNA and mRNA expression profiles in hypertensive mouse aortae
Authors: Tan Na , Zhang Yi , Zhang Yan , Li Li , Zong Yi , Han Wenwen , Liu Limei 
Published: February 2021

Objective
The current study investigated the mechanism underlying the therapeutic effects of berberine in the vasculature in hypertension.

Methods
Angiotensin II (Ang II)-loaded osmotic pumps were implanted in C57BL/6J mice with or without berberine administration. Mouse aortae were suspended in myograph for force measurement. Microarray technology were performed to analyze expression profiles of lncRNAs and mRNAs in the aortae. These dysregulated expressions were then validated by qRT-PCR. LncRNA-mRNA co-expression network was constructed to reveal the specific relationships.

Results
Ang Ⅱ resulted in a significant increase in the blood pressure of mice, which was suppressed by berberine. The impaired endothelium-dependent aortic relaxation was restored in hypertensive mice. Microarray data revealed that 578 lncRNAs and 554 mRNAs were up-regulated, while 320 lncRNAs and 377 mRNAs were down-regulated in the aortae by Ang Ⅱ; both were reversed by berberine treatment. qRT-PCR validation results of differentially expressed genes (14 lncRNAs and 6 mRNAs) were completely consistent with the microarray data. GO analysis showed that these verified differentially expressed genes were significantly enriched in terms of “cellular process”, “biological regulation” and “regulation of biological process”, whilst KEGG analysis identified vascular function-related pathways including cAMP signaling pathway, cGMP-PKG signaling pathway, and calcium signaling pathway etc. Importantly, we observed that lncRNA ENSMUST00000144849, ENSMUST00000155383, and AK041185 were majorly expressed in endothelial cells.

Conclusion
The present results suggest that the five lncRNAs ENSMUST00000144849, NR_028422, ENSMUST00000155383, AK041185, and uc.335+ might serve critical regulatory roles in hypertensive vasculature by targeting pivotal mRNAs and subsequently affecting vascular function-related pathways. Moreover, these lncRNAs were modulated by berberine, therefore providing the novel potential therapeutic targets of berberine in hypertension. Furthermore, lncRNA ENSMUST00000144849, ENSMUST00000155383, and AK041185 might be involved in the preservation of vascular endothelial cell function.
MODEL PEMASARAN BATU BATA RAMAH LINGKUNGAN BERDASARKAN PERSEPSI KONSUMEN
Authors: Devi Anita Oktaviana Trisna , Primasanti Yunita 
Published: February 2021

Batu bata merupakan salah satu komponen yang banyak digunakan dalam pendirian sebuah bangunan, baik perumahan, hotel, apartemen, industri, maupun fasilitas-fasilitas publik. Ancaman kerusakan ligkungan akibat munculnya industri batu bata tidak dapat dihindari jika bahan baku utama, batu bata, hanya menggunakan tanah liat. Oleh karena itu, saat ini sudah mulai muncul inovasi batu bata yang lebih ramah lingkungan dengan memanfaatkan limbah, seperti dilakukan salah satu pengrajin batu bata di daerah Kabupaten Karanganyar yang menggunakan limbah pabrik gula. Salah satu permasalahan yang umum dihadapi dalam implementasi produk ramah lingkungan adalah kurangnya kesadaran masyarakat yang disebabkan minimnya sumber informasi sehingga konsumen ragu membeli produk tersebut. Oleh karena itu, perlu dilakukan suatu penelitian mengenai model pemasaran batu bata ramah lingkungan dengan mempertimbangkan persepsi konsumen. Penelitian ini menggunakan metode STPD dan bauran pemasaran yang meliputi 8P. Hasil penelitian menunjukkan bahwa tiga atribut produk yang paling banyak dipertimbangkan adalah harga, fungsi produk, dan kelebihan produk berupa tahan gempa. Di sisi lain, responden paling banyak menginginkan batu bata yang aman, sehat, berasal dari produsen terpercaya, dan ramah lingkungan. Terkait karakteristik responden terhadap pemilihan batu bata ramah lingkungan, diketahui bahwa responden property syariah lebih menyukai batu bata ramah lingkungan. AbstractBricks are one component that is widely used in buildings, both housing, hotels, apartments, industry, and public facilities. The threat of environmental damage due to damage to the brick industry cannot be released if the main raw material for bricks uses only clay. Therefore, at this time has begun to appear more environmentally friendly bricks using waste, as did one of the brick craftsmen in Karanganyar Regency who used sugar mill waste. One that questions the common problem in implementing environmentally friendly products is reducing public awareness which reduces the source of information so as to make consumers hesitate to buy the product. Therefore, it is necessary to conduct research on environmentally friendly brick models by considering consumer perceptions. This research uses STPD method and marketing mix provided by 8P. The results showed that the three most preferred product attributes were price, product function, and product strength in the form of earthquake resistance. On the other hand, respondents most like bricks that are safe, healthy, requested from trusted manufacturers, and environmentally friendly. Regarding the characteristics of respondents regarding the selection of environmentally friendly bricks, Islamic property respondents are expected to prefer environmentally friendly bricks. Keywords: environmentally friendly bricks; STPD; mix marketing
ANALISIS PEMILIHAN SUPPLIER MENGGUNAKAN METODE ANALYTICAL NETWORK PROCESS (ANP) PADA PENGADAAN KOMPONEN RAIL PAD 158-7 (STUDI KASUS : PT PINDAD (PERSERO))
Authors: Bakhtiar Arfan , Rahmadani Dewita , Lathuihamalo Deliana , Maulana Bagus 
Published: February 2021

Pemilihan supplier merupakan salah satu keputusan strategis dalam manajemen rantai pasok yang berpengaruh terhadap peningkatan keunggulan kompetitif suatu perusahaan. Setiap pabrikan perlu memiliki kriteria standar dalam pemilihan supplier sesuai dengan kebutuhan perusahaan. Tujuan dari penelitian ini adalah mengetahui kriteria-kriteria yang paling berpengaruh dan urutan alternatif supplier Rail Pad 158-7 terbaik yang bisa digunakan untuk menjadi bahan pertimbangan oleh PT. Pindad (Persero) dalam memilih supplier di masa yang akan datang. Bobot dan prioritas kriteria yang diuji dengan Metode Analytical Network Process (ANP) juga dimaksudkan untuk memunculkan hubungan timbal balik yang saling berpengaruh antar kriteria. ANP dapat digunakan untuk membantu membuat keputusan untuk memilih supplier dan untuk mengelola kinerja rantai pasokan. Makalah ini menunjukkan kriteria yang mempengaruhi keputusan pemilihan suatu supplier yaitu faktor biaya, delivery, kualitas, dan service sebagai prioritas utama produksi perusahaan. Adapun jika terdapat perbedaan maka perbedaan perspektif dipengaruhi oleh tingkat minat dan tanggung jawab yang berbeda. Perbedaan penilaian ini membentuk dasar pengambilan keputusan dan kebijakan strategis rantai pasokan sesuai dengan kondisi perusahaan. Abstract [Analysis of Supplier Selection Using Analytical Network Process (ANP) Method in Procurement of Rail Pad 158-7 Components (Case Study: PT. Pindad (Persero))] Supplier selection is one of the strategic decisions in supply chain management that affects the improvement of a company's competitive advantage. Each manufacturer needs to have standard criteria in the selection of suppliers according to company needs. The purpose of this paper is to find out the most influential criteria and the best alternative order of Rail Pad 158-7 suppliers that can be used as a material for consideration by PT PINDAD (Persero) in selecting future suppliers. The weight and priority of the criteria tested by the Analytical Network Process (ANP) Method are also intended to bring up mutually influential relationships between criteria. ANP can be used to help make decisions to choose suppliers and to manage supply chain performance. This paper shows the criteria that influence a supplier selection decision, which are cost, delivery, quality, and service as the main priority of the company's production. As for if there are differences, differences in perspective are influenced by different levels of interest and responsibility. This difference in valuation forms the basis of supply chain strategic decision-making and policy according to company conditions.Key words: ANP; Criteria; MCDM; Supplier
PERANCANGAN DECISION RULE PADA PRODUKSI KULIT KIKIL SAPI DENGAN MENGGUNAKAN METODE DECISION TREE DI PABRIK TIGA BERSAUDARA
Authors: Putro Bramantiyo Eko , Saepurohman Tatan 
Published: February 2021

Pabrik Tiga Bersaudara merupakan perusahaan yang bergerak di bidang industri makanan dengan produk berupa kikil sapi. Persaingan bisnis setiap tahunnya semakin kompetitif, berdasarkan data Badan Pusat Statistik menunjukkan bahwa persaingan bisnis pada komoditas daging sapi di Cianjur mengalami peningkatan. Persaingan tersebut memaksa perusahaan mencari berbagai alternatif untuk unggul. Peningkatan kualitas merupakan salah satu solusi agar dapat bersaing. Penelitian ini bertujuan merancang decision rule untuk produksi kulit kikil sapi di pabrik Tiga Bersaudara. Pengumpulan data dilakukan dengan cara observasi dan wawancara, diperoleh 110 data proses produksi. Data diolah dengan metode decision tree menggunakan RapidMiner dan dilakukan perancangan decision rule. Berdasarkan analisis perancangan decision rule variabel yang perlu dipertimbangkan dalam mementukan kualitas kulit kikil sapi adalah temperatur air pemasakan, lama pemesanan, volume perendaman air 2 dan 3. Aturan keputusan yang terbentuk adalah jika temperatur pemasakan ≤ 95.75° C maka kita harus melihat data lamanya pemesanan bahan baku. Jika waktu pemesanan bahan baku ≤ 18,5 hari, hasilnya akan bagus. Anteseden ini memiliki konsekuensi terbaik yang menghasilkan prediksi benar 48,1% dengan tingkat kemurnian prediksi 100%. Abstract[Decision Rule Design On Beef Knuckle Production Using Decision tree Method In Tiga Bersaudara Factory] Tiga Bersaudara Factory is a company engaged in the food industry with beef knuckles product. Business competition is getting more competitive every year, based on data from the Central Bureau of Statistics, it shows that business competition for beef in Cianjur has increased. This competition forces companies to look for various alternatives to excel. Quality improvement is one solution in order to compete. This study aims to design a decision rule for the production of beef knuckles hides in the Tiga Bersaudara factory. Data collection was carried out by means of observation and interviews, obtained 110 production process data. The data is processed using a decision tree method using Rapid Miner and a decision rule is designed. Based on the analysis of the decision rule design, the variables that need to be considered in determining the quality of cow gravel hull are cooking water temperature, ordering time, water immersion volume 2 and 3.The decision rule that is formed is if the cooking temperature is ≤ 95.75 ° C then we must look at the data on the length of ordering the material. If the ordering time for raw materials is ≤ 18.5 days, the result will be good. This antecedent had the best consequence resulting in a true prediction of 48.1% with a predictive purity level of 100%.Keywords: Decision tree; Decision Rule; Quality; Beef Knuckle
Variable Statistical Structure of Neuronal Spike Trains in Monkey Superior Colliculus
Authors: Cho Seong-Hah , Crapse Trinity , Grimaldi Piercesare , Lau Hakwan , Basso Michele A. 
Published: February 2021

Popular models of decision-making propose that noisy sensory evidence accumulates until reaching a bound. Behavioral evidence as well as trial-averaged ramping of neuronal activity in sensorimotor regions of the brain support this idea. However, averaging activity across trials can mask other processes, such as rapid shifts in decision commitment, calling into question the hypothesis that evidence accumulation is encoded by delay period activity of individual neurons. We mined two sets of data from experiments in four monkeys in which we recorded from superior colliculus neurons during two different decision-making tasks and a delayed saccade task. We applied second-order statistical measures and spike train simulations to determine whether spiking statistics were similar or different in the different tasks and monkeys, despite similar trial-averaged activity across tasks and monkeys. During a motion direction discrimination task, single-trial delay period activity behaved statistically consistent with accumulation. During an orientation detection task, the activity behaved superficially like accumulation, but statistically consistent with stepping. Simulations confirmed both findings. Importantly, during a simple saccade task, with similar trial-averaged activity, neither process explained spiking activity, ruling out interpretations based on differences in attention, reward, or motor planning. These results highlight the need for exploring single-trial spiking dynamics to understand cognitive processing and raise the interesting hypothesis that the superior colliculus participates in different aspects of decision-making depending on task differences.SIGNIFICANCE STATEMENTHow are decisions based on sensory information transformed into actions? We report that single-trial neuronal activity dynamics in the superior colliculus of monkeys show differences in decision-making tasks depending on task idiosyncrasies and requirements and despite similar trial-averaged ramping activity. These results highlight the importance of exploring single-trial spiking dynamics to understand cognitive processing and raise the interesting hypothesis that the superior colliculus participates in different aspects of decision-making depending on task requirements.
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy
Authors: Holoman Nicholas C. , Aiello Jacob J. , Trobenter Timothy D. , Tarchick Matthew J. , Kozlowski Michael R. , Makowski Emily R. , De Vivo Darryl C. , Singh Charandeep , Sears Jonathan E. , Samuels Ivy S. 
Published: February 2021

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR). Inadequate glycemic control exacerbates retinopathy, while normalization of glucose levels delays its progression. In hyperglycemia, hexokinase is saturated and excess glucose is metabolized to sorbitol by aldose reductase via the polyol pathway. Therapies to reduce retinal polyol accumulation for the prevention of DR have been elusive because of low sorbitol dehydrogenase levels in the retina and inadequate inhibition of aldose reductase. Using systemic and conditional genetic inactivation, we targeted the primary facilitative glucose transporter in the retina, Glut1, as a preventative therapeutic in diabetic male and female mice. Unlike WT diabetics, diabeticGlut1+/−mice did not display elevated Glut1 levels in the retina. Furthermore, diabeticGlut1+/−mice exhibited ameliorated ERG defects, inflammation, and oxidative stress, which was correlated with a significant reduction in retinal sorbitol accumulation. Retinal pigment epithelium-specific reduction of Glut1 did not prevent an increase in retinal sorbitol content or early hallmarks of DR. However, like diabeticGlut1+/−mice, reduction of Glut1 specifically in the retina mitigated polyol accumulation and diminished retinal dysfunction and the elevation of markers for oxidative stress and inflammation associated with diabetes. These results suggest that modulation of retinal polyol accumulation via Glut1 in photoreceptors can circumvent the difficulties in regulating systemic glucose metabolism and be exploited to prevent DR.SIGNIFICANCE STATEMENTDiabetic retinopathy affects one-third of diabetic patients and is the primary cause of vision loss in adults 20-74 years of age. While anti-VEGF and photocoagulation treatments for the late-stage vision threatening complications can prevent vision loss, a significant proportion of patients do not respond to anti-VEGF therapies, and mechanisms to stop progression of early-stage symptoms remain elusive. Glut1 is the primary facilitative glucose transporter for the retina. We determined that a moderate reduction in Glut1 levels, specifically in the retina, but not the retinal pigment epithelium, was sufficient to prevent retinal polyol accumulation and the earliest functional defects to be identified in the diabetic retina. Our study defines modulation of Glut1 in retinal neurons as a targetable molecule for prevention of diabetic retinopathy.