bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Positive End-Expiratory Pressure on Lung Recruitment, Respiratory Mechanics, and Intracranial Pressure in Mechanically Ventilated Brain-Injured Patients
Authors: Robba Chiara , Ball Lorenzo , Nogas Stefano , Battaglini Denise , Messina Antonio , Brunetti Iole , Minetti Giuseppe , Castellan Lucio , Rocco Patricia R. M. , Pelosi Paolo 
Published: October 2021

Background: The pathophysiological effects of positive end-expiratory pressure (PEEP) on respiratory mechanics, lung recruitment, and intracranial pressure (ICP) in acute brain-injured patients have not been completely elucidated. The primary aim of this study was to assess the effects of PEEP augmentation on respiratory mechanics, quantitative computed lung tomography (qCT) findings, and its relationship with ICP modifications. Secondary aims included the assessment of the correlations between different factors (respiratory mechanics and qCT features) with the changes of ICP and how these factors at baseline may predict ICP response after greater PEEP levels.Methods: A prospective, observational study included mechanically ventilated patients with acute brain injury requiring invasive ICP and who underwent two-PEEP levels lung CT scan. Respiratory system compliance (Crs), arterial partial pressure of carbon dioxide (PaCO2), mean arterial pressure (MAP), data from qCT and ICP were obtained at PEEP 5 and 15 cmH2O.Results: Sixteen examinations (double PEEP lung CT and neuromonitoring) in 15 patients were analyzed. The median age of the patients was 54 years (interquartile range, IQR = 39–65) and 53% were men. The median Glasgow Coma Scale (GCS) at intensive care unit (ICU) admission was 8 (IQR = 3–12). Median alveolar recruitment was 2.5% of total lung weight (−1.5 to 4.7). PEEP from 5 to 15 cmH2O increased ICP [median values from 14.0 (11.2–17.5) to 23.5 (19.5–26.8) mmHg, p &lt; 0.001, respectively]. The amount of recruited lung tissue on CT was inversely correlated with the change (Δ) in ICP (rho = −0.78; p = 0.0006). Additionally, ΔCrs (rho = −0.77, p = 0.008), ΔPaCO2 (rho = 0.81, p = 0.0003), and ΔMAP (rho = −0.64, p = 0.009) were correlated with ΔICP. Baseline Crs was not predictive of ICP response to PEEP.Conclusions: The main factors associated with increased ICP after PEEP augmentation included reduced Crs, lower MAP and lung recruitment, and increased PaCO2, but none of these factors was able to predict, at baseline, ICP response to PEEP. To assess the potential benefits of increased PEEP in patients with acute brain injury, hemodynamic status, respiratory mechanics, and lung morphology should be taken into account.
Enhanced Plasmonic Biosensor Utilizing Paired Antibody and Label-Free Fe3O4 Nanoparticles for Highly Sensitive and Selective Detection of Parkinson’s α-Synuclein in Serum
Authors: Mandala Samuel Husin Surya , Liu Tai-Jan , Chen Chiung-Mei , Liu Kuo-Kang , Januar Mochamad , Chang Ying-Feng , Lai Chao-Sung , Chang Kuo-Hsuan , Liu Kou-Chen 
Published: October 2021

Parkinson’s disease (PD) is an acute and progressive neurodegenerative disorder, and diagnosis of the disease at its earliest stage is of paramount importance to improve the life expectancy of patients. α-Synuclein (α-syn) is a potential biomarker for the early diagnosis of PD, and there is a great need to develop a biosensing platform that precisely detects α-syn in human body fluids. Herein, we developed a surface plasmon resonance (SPR) biosensor based on the label-free iron oxide nanoparticles (Fe3O4 NPs) and paired antibody for the highly sensitive and selective detection of α-syn in serum samples. The sensitivity of the SPR platform is enhanced significantly by directly depositing Fe3O4 NPs on the Au surface at a high density to increase the decay length of the evanescent field on the Au film. Moreover, the utilization of rabbit-type monoclonal antibody (α-syn-RmAb) immobilized on Au films allows the SPR platform to have a high affinity-selectivity binding performance compared to mouse-type monoclonal antibodies as a common bioreceptor for capturing α-syn molecules. As a result, the current platform has a detection limit of 5.6 fg/mL, which is 20,000-fold lower than that of commercial ELISA. The improved sensor chip can also be easily regenerated to repeat the α-syn measurement with the same sensitivity. Furthermore, the SPR sensor was applied to the direct analysis of α-syn in serum samples. By using a format of paired α-syn-RmAb, the SPR sensor provides a recovery rate in the range from 94.5% to 104.3% to detect the α-syn in diluted serum samples precisely. This work demonstrates a highly sensitive and selective quantification approach to detect α-syn in human biofluids and paves the way for the future development in the early diagnosis of PD.
Microstructure Design and Its Effect on Mechanical Properties in Gamma Titanium Aluminides
Authors: Liu Xuqi , Lin Qia , Zhang Wenjing , Horne Constance Van , Cha Limei 
Published: October 2021

Intermetallic gamma titanium aluminides display attractive engineering properties at high temperatures of up to 750 °C. To date, they have been used in low-pressure turbine blades and turbocharger rotors in advanced aircraft and automotive engines. This review summarizes the fundamental information of the Ti–Al system. After providing the development of γ TiAl alloys, typical phases, microstructures and their characteristics in TiAl alloys, the paper focuses on the effects of alloying elements on the phase boundary shifting, stabilizing effects and strengthening mechanism. The relationships between chemical additions, microstructure evolution and mechanical properties of the alloy are discussed. In parallel, the processing technologies and the common heat treatment methods are described in detail, both of which are applied to optimize the mechanical properties via adjusting microstructures. On this basis, the effects from chemical composition, processing technologies and heat treatments on microstructure, which controls the mechanical properties, can be obtained. It has a certain guiding significance for tailoring the microstructures to gain desired mechanical properties.
Control of Strongyles in First-Season Grazing Ewe Lambs by Integrating Deworming and Thrice-Weekly Administration of Parasiticidal Fungal Spores
Authors: Voinot Mathilde , Bonilla Rodrigo , Sousa Sérgio , Sanchís Jaime , Canhão-Dias Miguel , Romero Delgado José , Lozano João , Sánchez-Andrade Rita , Sol Arias María , Madeira de Carvalho Luís 
Published: October 2021

Parasiticidal fungi have been used in several in vivo experiments in livestock farms worldwide, constituting an effective tool for the biocontrol of gastrointestinal parasites in grazing animals. In the first year of study, two groups of eight first-season pasturing ewe lambs infected by strongyles were dewormed with albendazole, and then, the test group received an oral dose of 106 chlamydospores of Mucor circinelloides and 106 Duddingtonia flagrans individually and thrice a week from mid-September to May (FS1), while the control group remained without fungi (CT1). In the second year, two new groups of first-season grazing ewe lambs were treated with ivermectin and subjected to the same experimental design (FS2 and CT2, respectively). The anthelmintic efficacy was 96.6% (CT1), 95.6% (FS1), 96.1% (CT2), and 95.1% (FS2). The counts of strongyle egg output increased in the control groups (CT1 and CT2) throughout the study and reached numbers higher than 600 eggs per gram of feces (EPG), while in FS1 and FS2, they were <250 EPG. The values of red blood cell parameters registered for CT1 and CT2 were lower than those of the reference standards, while a significant increment was recorded in FS1 and FS2, and values within the physiological range were attained. It is concluded that integrating efficient anthelminthic deworming with rotational pasturing and the regular intake of chlamydospores of M. circinelloides and D. flagrans provides a helpful strategy for maintaining low levels of strongyle egg output in first-season grazing ewe lambs and improves their health status.
Analisis Media Pembelajaran Berbasis E-Learning di Masa Pandemi Covid-19 pada Guru SD/MI di Jember
Authors: Azrina Nuril , Latifah Siti 
Published: October 2021

This study aims to analyze e-learning-based learning media during the COVID-19 pandemic used by SD / MI teachers in Jember and the factors that support and hinder the e-learning based learning media. The method used in this research is descriptive qualitative method. Respondents in this study were SD / MI teachers in Jember. The data was collected by distributing questionnaires and online interviews. The results showed that during the COVID-19 pandemic, SD / MI teachers in Jember conducted e-learning based learning. The e-learning-based learning media that is most widely used is Whatsapp as the main media for e-learning based learning. Then as supporting media, SD / MI teachers also use Google Classroom, Edmoodo, Zoom, Quizizz, and other e-learning based learning media. In using e-learning based learning media, the biggest obstacle is the internet quota, then there are other inhibiting factors such as internet network access, facilities / infrastructure, time, skills in using learning media. While the factors that support SD / MI teachers in using e-learning-based learning media are e-learning features, facilities / infrastructure, internet quotas, skills in using learning media.
Keywords: e-learning, learning media, COVID-19, teachers.

Penelitian ini bertujuan untuk menganalisis media pembelajaran berbasis e-learning di masa pandemi COVID-19 yang digunakan oleh guru SD/MI di Jember dan faktor yang mendukung seta menghambat media pembelajaran berbasis e-learning tersebut. Metode yang digunakan dalam penelitian ini menggunakan metode deskriptif kualitatif. Responden dalam penelitian ini adalah guru SD/MI di Jember.Pengumpulan data dilakukan dengan menyebarkan kuesioner dan wawancara secara online. Hasil penelitian menunjukkan bahwa saat pandemi COVID-19 membuat guru SD/MI di Jember melakukan pembelajaran berbasis e-learning. Media pembelajaran berbasis e-learning yang paling banyak digunakan adalah Whatsapp sebagai media utama pembelajaran berbasis e-learning. Kemudian sebagai media pendukungnya guru SD/MI juga menggunakan Google Classroom, Edmoodo, Zoom, Quizizz, dan media pembelajaran berbasis e-learning lainnya. Dalam menggunakan media pembelajaran berbasis e-learning yang menjadi hambatan paling besar adalah kuota internet, kemudian juga terdapat faktor penghambat yang lain seperti akses jaringan internet, fasilitas/sarana prasarana, waktu, skill menggunakan media pembelajaran. Sedangkan faktor yang mendukung guru SD/MI dalam menggunakan media pembelajaran berbasis e-learning yaitu fitur-fitur e-learning, fasilitas/sarana prasarana, kuota internet, skill menggunakan media pembelajaran.
Kata Kunci: e-learning, media pembelajaran, COVID-19, guru.
ANALISIS LEMBAR KERJA PESERTA DIDIK (LKPD) SEBAGAI BAHAN AJAR BIOLOGI
Authors: Istiqomah Ely 
Published: October 2021

This research aims to determine the utilization and suitability of the contents of Students Worksheets as a biology teaching material XI IPA class with the curriculum 2013 at SMAN 3 Jember year lesson 2018/2019. Utilization of Students Worksheets to determine the process of drafting SW, the implementation of biological learning using SW. The suitability of LKPD content is analyzed based on display, material, linguistic and question. This research is a qualitative descriptive research. Data analysis is done by calculating the percentage of students Worksheets conformity components. The results of this research for the students worksheet which is compiled sui table using various methods of learning. Results of conformity student workshe ets with the curriculum 2013 class XI IPA at SMAN 3 Jember has a level of conformity is still less in accordance with the standards set by Permendikbud number 8 year 2016 unit that is the view section Includes the Skins section, the beginning of the book, the content, and the end gets 83.3%. There are still two basic competencies that are not listed on the studente worksheet. The average linguistic section gets a value of 80%. The question section gets an average value of 66.6%.
Keyword: curriculum 2013, student worksheet conformity, student worksheets, teaching materials
Penelitian ini bertujuan untuk mengetahui pemanfaatan dan kesesuaian isi Lembar Kerja Peserta Didik (LKPD) sebagai bahan ajar biologi kelas XI IPA menggunakan kurikulum 2013 di SMAN 3 Jember tahun pelajaran 2018/2019. Pemanfaatan LKPD untuk mengetahui proses penyusunan LKPD, pelaksanaan pembelajaran biologi menggunakan LKPD, dan evaluasi pembelajaran. Kesesuaian isi LKPD dianalisis berdasarkan tampilan, materi, kebahasaan dan soal. Penelitian ini merupakan penelitian kualitatif deskriptif. Analisis data dilakukan dengan menghitung persentase komponen kesesuaian LKPD. Hasil penelitian ini bahwa LKPD yang disusun dapat digunakan dengan berbagai metode pembelajaran. Hasil kesesuaian LKPD dengan kurikulum 2013 kelas XI IPA di SMAN 3 Jember memiliki tingkat kesesuaian masih kurang sesuai dengan standar yang ditetapkan oleh Permendikbud nomor 8 Tahun 2016 tentang buku yang digunakan oleh satuan pendidikan yaitu bagian tampilan meliputi bagian kulit, awal buku, isi, dan bagian akhir. Bagian penyajian yaitu 83,3%. Bagian materi masih terdapat dua Kompetensi Dasar yang belum tercantum pada LKPD yaitu bab sistem reproduksi dan sistem imun. Bagian kebahasaan rata-rata 80%. Bagian soal mendapatkan nilai rata-rata 66,6%. Hal ini menunjukkan bahwa LKPD biologi kelas XI IPA di SMAN 3 Jember masih kurang baik dalam segi penyusunannya akan tetapi layak digunakan karena soal yang disusun guru mengajak siswa untuk berpikir kritis.
Kata Kunci: bahan ajar, lembar kerja peserta didik, kesesuaian lembar kerja peserta didik, kurikulum 2013
METODOLOGIA INVESTIGATIVA NO ENSINO DA CINÉTICA QUÍMICA
Authors: Romero da Silva André , Vilela Paiva Maria Auxiliadora 
Published: October 2021

Os processos químicos presentes nas indústrias de transformação, o envelhecimento do nosso organismo, o crescimento das plantas e a geração das chuvas, são exemplos de processos controlados por fatores cinéticos que permeiam nossa rotina diária. Aulas fundamentadas em exemplos abstratos e com excesso de cálculos matemáticos diminuem o interesse dos alunos em aprender este conteúdo, assim como, não contribuem para formar professores conscientes da importância da ciência química e sua relação com a sociedade e com o meio ambiente. Com o intuito de realizar uma intervenção pedagógica no ensino de cinética química, esta pesquisa teve por objetivo avaliar se uma metodologia investigativa propicia aos alunos a habilidade de investigar e refletir sobre fatos observados na disciplina de Cinética Química. A pesquisa desenvolvida com os alunos da Licenciatura em Química de uma Instituição Pública, demonstrou que a metodologia investigativa foi capaz de desenvolver a habilidade de observação e reflexão dos graduandos sobre a ocorrência de uma reação química. No entanto, a ausência dos conceitos matemáticos, incluindo o de derivada, dificultou o desenvolvimento de um procedimento experimento por parte dos alunos, exigindo o replanejamento de ações no laboratório. Verificou-se que a metodologia investigativa favorece a interação e comunicação entre os pares, auxiliando no estabelecimento de uma metodologia experimental a ser aplicada por cada grupo para responder aos questionamentos relativos a reação de tiossulfato em meio ácido. Tal prática trouxe ao ambiente educacional a discussão sobre a geração de resíduo laboratorial, qualificando os alunos a trabalharem com quantidades suficientes de reagentes para se atingir os mesmos resultados que seriam atingidos com grandes quantidades, além de associar a intervenção pedagógica às influências da cinética química junto às questões ambientais.
UM OLHAR SOBRE A TRAJETÓRIA DO MUSEU DE CIÊNCIA RICARDO FERREIRA
Authors: Costa Araújo Carlos Wagner , Pinto Ribeiro Marcos Antonio , Santos Amaral Batista Lindsai , Alves Sobral Yuri Rafael 
Published: October 2021

Neste estudo, que tem característica da pesquisa qualitativa, discutimos os caminhos teóricos, metodológicos e trajetória do Museu de Ciência Ricardo Ferreira - MCRF, a partir de discussões realizadas no Mestrado em Educação em Ciências: Químicas da Vida e Saúde da Universidade Federal do Rio Grande do Sul – UFRGS. O Museu fica localizado na Escola de Referência Estadual Otacílio Nunes de Souza (EREMONS), Petrolina, sertão de Pernambuco. Um dos objetivos é tentar responder o seguinte problema: como as atividades de educação científica e popularização da ciência, pautadas em preceitos freireanos, podem contribuir para a cultura científica e o ensino de ciências de jovens estudantes e professores da comunidade escolar, em questão? O MCRF, foi fundado no ano de 2012, em 2015, começou a fazer parte do Projeto Político Pedagógico da escola, que é de educação em tempo integral. O texto está organizado em discussões teóricas, ações, análises do percurso e trajetória do MCRF, numa discussão sobre a perspectiva de um espaço não formal dentro de uma escola de ensino médio da educação básica. A construção de um espaço não formal, com a pedagogia da pergunta, temas geradores e dialogicidade em Freire, vem proporcionando a aprendizagem dos jovens estudantes, através de argumentos, assim como conflitos e a construção de conceitos científicos, antes considerados trágicos.
НЕЗАЛЕЖНІСТЬ УКРАЇНИ В СУЧАСНОМУ СУСПІЛЬНОМУ ДИСКУРСІ
Authors: Slyusarevskyy Mykola 
Published: October 2021

Обговорюються оприлюднені під час урочистого засідання Вченої ради Інституту соціальної та політичної психології Національної академії педагогічних наук України результати масового репрезентативного опитування громадської думки щодо державної незалежності України та її символів. Протягом 1-12 серпня 2021 р. опитано 1200 громадян за вибіркою, що репрезентує доросле населення України. Показано стійку тенденцію зростання частки громадян, які відносять проголошення незалежності України в 1991 році до здобутків українського народу, що найбільше заслуговують бути предметом його національної гордості. Ця тенденція найбільше простежується серед людей віком від 30 до 55 років і відображає процеси, що відбуваються в суспільній свідомості певною мірою спонтанно, без цілеспрямованих формувальних зусиль з боку державних та інших інститутів впливу. На основі порівняння даних опитування з результатами Всеукраїнського референдуму 1 грудня 1991 р., розрахованими відносно загальної кількості дорослого населення України, продемонстровано тенденцію зростання в українському суспільстві підтримки Акта проголошення державної незалежності.
A checklist and areography of longhorn beetles (Coleoptera: Cerambycidae) in Rila Mountain
Authors: Georgiev Georgi , Sakalian Vladimir , Mirchev Plamen , Georgieva Margarita , Belilov Sevdalin 
Published: October 2021

The complex of longhorn beetles in Rila Mt. in Bulgaria was studied by literature data and original biological materials. As a result, 126 taxa from six subfamilies were established, as follows: Prioninae (four taxa), Lepturinae (43 taxa), Necydalinae (two taxa), Spondylidinae (seven taxa), Cerambycinae (31 taxa) and Lamiinae (39 taxa).
In this study, two new records for Rila Mt. (Stenurella nigra nigra and Xylosteus spinolae) and new localities or additional information for 24 cerambycid taxa were reported. The longhorn beetles belong to 18 zoogeographical categories and seven complexes. The European complex occupies a dominant position (37.3%), followed by the Palaearctic (23.8%), Eurosiberian (13.5%), Mediterranean (11.1%), European-Iranoturanian (7.1%), Balkan endemic (4.0%) and Holarctic (3.2%) complexes.
Anticipation et travail du vieillir
Authors: Fromage Benoît 
Published: October 2021

Cette recherche a pour objet l’étude de l’anticipation et de son évolution pendant un an chez des sujets âgés entrant en logement-foyer. L’utilisation d’un outil spécifique (Épreuve d’anticipation de M. Berta) permet de mettre en évidence l’enjeu indentitaire de la temporalité et les changements qui surviennent à la faveur de ce qui apparaît comme un événement majeur. Les réaménagements observés appellent à de nouvelles considérations sur l’accompagnement d’une activité psychique primordiale : le travail du Vieillir.
L’évaluation de la qualité de vie chez le sujet dément : une nécessité ?
Authors: Jolly Damien 
Published: October 2021

La notion de qualité de vie est une notion indissociable du concept de santé positive. Chez le patient dément qualifié d'inaccessible, il est habituel de considérer que, de perte en perte, le sujet pensant disparaît. S'intéresser à sa qualité de vie devrait permettre de comparer les différents types de prise en charge proposés à ce patient (éventuellement médicamenteuse), ainsi que les structures qui l'accueillent. Afin de donner des pistes pour cette évaluation, nous présentons les principaux déterminants de la qualité de vie chez le sujet dément : la satisfaction des besoins fondamentaux, l'existence de morbidités associées, l'environnement et, en particulier, les lieux de vie, les interrelations avec son entourage. Un chapitre, « Mesure de la qualité de vie », présente des réflexions faites quant à l'utilisation d'outils déjà validés, mais, également, propose d'autres approches de mesures objectives et subjectives de la qualité de vie.
La DHEA : une nouvelle jeunesse au grand âge ?
Authors: Legrain Sylvie , Faucounau Véronique 
Published: October 2021

La déhydroépiandrostérone (DHEA) et son sulfate (S-DHEA) sont des stéroïdes sécrétés par les corticosurrénales dont la concentration sanguine diminue avec l’âge, avec cependant une grande variation interindividuelle. Cette décroissance laisse supposer que la DHEA joue un rôle dans le veillissement. Des essais cliniques de supplémentation en DHEA sur de courtes périodes ont montré une action au niveau du système immunitaire et une amélioration du « bien-être ». L’absence de recul dans l’administration au long cours de DHEA montre la nécessité de réaliser des essais randomisés à grande échelle et à plus long terme.
La psychologie à l’hôpital
Authors: Léonard Marie-Claude , Mollard Judith 
Published: October 2021

Souvent définie comme la science des phénomènes de la vie intérieure du sujet, la psychologie implantée à l’hôpital doit aussi intégrer la dimension institutionnelle, c’est-à-dire inter-relationnelle. La psychologie à l’hôpital gériatrique vise à maintenir un certain équilibre entre forces de vie et forces de mort, en favorisant les échanges entre dedans et dehors. L’entrée en institution vient rompre l’organisation temporelle du patient ; il est alors confronté au paradoxe suivant : endurer la longueur du temps d’un avenir pourtant bien limité. À l’inverse le soignant enchaîne les tâches et, dans un même espace, se heurtent des rythmes différents. Dans ce lieu de soin, en fin de trajectoire de vie, la psychologie est souvent proche de la réflexion éthique, à savoir, respecter la singularité du sujet dans les soins qui lui sont apportés ; comment donner du sens à la souffrance exprimée par les patients dans l’attente de la mort.
L’hôpital de jour gériatrique
Authors: Abalain-Castela Christine , Laurent Mireille , Rhode Erika , Safouane Majid 
Published: October 2021

L’hôpital de jour gériatrique est un outil de travail très maniable, grâce à une grande souplesse dans ses prises en charge. Son intérêt premier est d’assurer une qualité de vie médico-psycho-sociale au malade, tout en lui permettant de rester à son domicile. Ce lieu peut être investi par les patients pareil à un endroit où ils sont traités comme des êtres ayant toutes leurs capacités, ce qui leur permet de retrouver une identité sociale nécessaire au bien-être de chacun. La permanence des soignants permet à tous d’avoir des référents stables. À l’hôpital de jour gériatrique de l’hôpital Charles-Foix, une grande diversité de prises en charge existe. En effet, les indications de prise en charge sont : les bilans diagnostiques, les prises en charge thérapeutiques, les rééducations, les indications psychiatriques, le maintien à domicile.