bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort profile: the Men and Parenting Pathways (MAPP) Study: a longitudinal Australian cohort study of men’s mental health and well-being at the normative age for first-time fatherhood
Authors: Macdonald Jacqui A , Francis Lauren M , Skouteris Helen , Youssef George J , Graeme Liam G , Williams Joanne , Fletcher Richard J , Knight Tess , Milgrom Jeannette , Di Manno Laura , Olsson Craig A , Greenwood Christopher J 
Published: July 2021

PurposeThe Men and Parenting Pathways (MAPP) Study is a prospective investigation of men’s mental health and well-being across the normative age for transitioning to fatherhood. This includes trajectories and outcomes for men who do and do not become fathers across five annual waves of the study.ParticipantsAustralian resident, English-speaking men aged 28–32 years at baseline were eligible. Recruitment was over a 2-year period (2015–2017) via social and traditional media and through engagement with study partners. Eight hundred and eighteen eligible men consented to participate. Of these, 664 men completed the first online survey of whom 608 consented to ongoing participation. Of the ongoing sample, 83% have participated in at least two of the first three annual online surveys.Findings to dateThree waves of data collection are complete. The first longitudinal analysis of MAPP data, published in 2020, identified five profiles that characterise men’s patterns of depressive symptom severity and presentations of anger. Profiles indicating pronounced anger and depressive symptoms were associated with fathers’ lack of perceived social support, and problems with coparenting and bonding with infants. In a second study, MAPP data were combined with three other Australian cohorts in a meta-analysis of associations between fathers’ self-reported sleep problems up to 3 years postpartum and symptoms of depression, anxiety and stress. Adjusted meta-analytic associations between paternal sleep and mental health risk ranged from 0.25 to 0.37.Future plansMAPP is an ongoing cohort study. Waves 4 and 5 data will be ready for analyses at the end of 2021. Future investigations will include crossed-lagged and trajectory analyses that assess inter-relatedness and changing social networks, mental health, work and family life. A nested study of COVID-19 pandemic-related mental health and coping will add two further waves of data collection in a subsample of MAPP participants.
SYMPERHEART: an intervention to support symptom perception in persons with heart failure and their informal caregiver: a feasibility quasi-experimental study protocol
Authors: Santos Gabrielle Cécile , Liljeroos Maria , Hullin Roger , Denhaerynck Kris , Wicht Justine , Jurgens Corrine Y , Schäfer-Keller Petra 
Published: July 2021

IntroductionSymptom perception in heart failure (HF) has been identified as crucial for effective self-care, and is related to patient and health system outcomes. There is uncertainty regarding the feasibility and acceptability of symptom perception support and doubts regarding how to include informal caregivers. This study aims to test the feasibility, acceptability and outcome responsiveness of an intervention supporting symptom perception in persons with HF and their informal caregiver.Methods and analysisA feasibility study with a quasi-experimental pretest and post-test single group design is conducted. The convenience sample consists of 30 persons with HF, their informal caregivers and six nurses. SYMPERHEART is an evidence-informed intervention that targets symptom perception by educational and support components. Feasibility is measured by time-to-recruit; time-to-deliver; eligibility rate; intervention delivery fidelity rate. Acceptability is measured by rate of consent, retention rate, treatment acceptability and the engagement in the intervention components. Outcome responsiveness includes: HF self-care (via the Self-care of Heart Failure Index V.7.2); perception of HF symptom burden (via the Heart Failure Somatic Perception Scale V.3); health status (via the Kansas City Cardiomyopathy Questionnaire-12); caregivers’ contribution to HF self-care (via the Caregiver Contribution to Self-Care of Heart Failure Index 2); caregivers’ burden (via the Zarit Burden Interview). Clinical outcomes include HF events, hospitalisation reason and length of hospital stay. Descriptive statistics will be used to report feasibility, acceptability, patient-reported outcomes (PRO) and clinical outcomes. PRO and caregiver-reported outcome responsiveness will be reported with mean absolute change and effect sizes.Ethics and disseminationThe study is conducted according to the Declaration of Helsinki. The Human Research Ethics Committee of the Canton of Vaud, Switzerland, has approved the study. Written informed consent from persons with HF and informal caregivers are obtained. Results will be published via peer reviewed and professional journals, and further disseminated via congresses.Trial registration numberISRCTN18151041.
Clinicopathological significance of neutrophil-rich colorectal carcinoma
Authors: Rottmann Bruce G , Patel Natalie , Ahmed Muhammad , Deng Yanhong , Ciarleglio Maria , Vyas Monika , Jain Dhanpat , Zhang Xuchen 
Published: July 2021

AimsThe importance of the interaction between tumour cells and neutrophils has recently begun to emerge. However, the significance of tumour-infiltrating neutrophil (TIN) in colorectal carcinomas (CRCs) remains unclear. The aim of this study was to investigate the prognostic significance of TIN in CRCs.MethodsCRCs were evaluated for TIN and were classified as neutrophil-rich (NR), neutrophil-intermediate (NI) and neutrophil-poor (NP) based on the presence of >15, 5–15 and <5 TIN per 100 tumour cells, respectively. Various clinicopathological parameters were recorded in each case including age, gender, histological grade, tumour, node, metastasis (TNM) stage, tumour location and DNA mismatch repair (MMR) status.ResultsAmong the 348 CRC cases reviewed, 38 cases were NR, 43 cases were NI and 267 cases were NP. High TIN was associated with higher histological grade (p=0.0222), right-sided tumour location (p=0.0025), advanced TNM stage (p=0.0346) and higher rate of MMR-deficient CRCs (p=0.0027). Patients with NR CRCs had significantly poorer 5-year recurrence-free survival comparing to patients with NI or NP CRCs on Kaplan-Meier analysis (p=0.0001) and high TIN remained an independent risk factor with multivariate analysis (p=0.0137; HR: 1.930, 95% CI: 1.144 to 3.255). NR CRCs are more commonly seen in MMR-deficient than in MMR-proficient CRCs (p=0.0006). Patients with MMR-deficient NR CRCs showed similar 5-year recurrence-free survival compared with MMR-proficient NR CRCs.ConclusionsOur findings reveal that high TIN confers poorer patient prognosis in both MMR-proficient and MMR-deficient CRCs.
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trial
Authors: Li Jian'an , Xia Wenguang , Zhan Chao , Liu Shouguo , Yin Zhifei , Wang Jiayue , Chong Yufei , Zheng Chanjuan , Fang Xiaoming , Cheng Wei , Reinhardt Jan D 
Published: July 2021

ObjectivesTo investigate superiority of a telerehabilitation programme for COVID-19 (TERECO) over no rehabilitation with regard to exercise capacity, lower limb muscle strength (LMS), pulmonary function, health-related quality of life (HRQOL) and dyspnoea.DesignParallel-group randomised controlled trial with 1:1 block randomisation.SettingThree major hospitals from Jiangsu and Hubei provinces, China.Participants120 formerly hospitalised COVID-19 survivors with remaining dyspnoea complaints were randomised with 61 allocated to control and 59 to TERECO.InterventionUnsupervised home-based 6-week exercise programme comprising breathing control and thoracic expansion, aerobic exercise and LMS exercise, delivered via smartphone, and remotely monitored with heart rate telemetry.OutcomesPrimary outcome was 6 min walking distance (6MWD) in metres. Secondary outcomes were squat time in seconds; pulmonary function assessed by spirometry; HRQOL measured with Short Form Health Survey-12 (SF-12) and mMRC-dyspnoea. Outcomes were assessed at 6 weeks (post-treatment) and 28 weeks (follow-up).ResultsAdjusted between-group difference in change in 6MWD was 65.45 m (95% CI 43.8 to 87.1; p<0.001) at post-treatment and 68.62 m (95% CI 46.39 to 90.85; p<0.001) at follow-up. Treatment effects for LMS were 20.12 s (95% CI 12.34 to 27.9; p<0.001) post-treatment and 22.23 s (95% CI 14.24 to 30.21; p<0.001) at follow-up. No group differences were found for lung function except post-treatment maximum voluntary ventilation. Increase in SF-12 physical component was greater in the TERECO group with treatment effects estimated as 3.79 (95% CI 1.24 to 6.35; p=0.004) at post-treatment and 2.69 (95% CI 0.06 to 5.32; p=0.045) at follow-up.ConclusionsThis trial demonstrated superiority of TERECO over no rehabilitation for 6MWD, LMS, and physical HRQOL.Trial registration numberChiCTR2000031834.
Increased carbohydrate availability effects energy and nutrient periodisation of professional male athletes from the Australian Football League
Authors: Salagaras Brie S. , Mackenzie-Shalders Kristen L. , Slater Gary J. , McLellan Chris , Coffey Vernon G. 
Published: July 2021

This research aimed to explore the effect of increased carbohydrate availability intervention on energy intake and distribution in professional Australian Football athletes. Six 24-h energy and macronutrient intakes were quantified (n = 19 males; age 24 ± 4 y, stature 187 ± 8 cm, mass 87 ± 9 kg) using photographic food diaries and Foodworks analyses. Energy expenditure was estimated for the same period using GeneActiv accelerometers. During 3 control days, athletes had ad libitum access to food, while the 3 intervention days increased carbohydrate availability, through greater prompting and access to carbohydrate foods. Daily energy intake was higher during intervention (185 ± 40 kJ/kg/d) compared with control (172 ± 31 kJ/kg/d; p < 0.05) but remained below estimated expenditure, and carbohydrate intake was also greater with intervention (5.0 ± 0.2 g/kg/d) than control (4.0 ± 0.2 g/kg/d; p < 0.05). Expenditure was highest during the morning, which coincided with lowest intake on all days, while the intervention was associated with greater carbohydrate intake in the morning (0.6 g/kg, p < 0.05) compared with control. Increasing availability of carbohydrate during high-load training generated a modest increase in carbohydrate and energy intake, and the intervention was most effective in improving carbohydrate intake during mornings. Novelty: Increased access and provision of carbohydrate foods increased carbohydrate consumption and energy intake on high training load days. Daily distribution of energy intake can be modified through actively promoting carbohydrate consumption.
Leptogenesis in supersymmetry with one L violating coupling
Authors: Adhikari Rathin , Dasgupta Arnab 
Published: July 2021

AbstractWe have shown a new scenario of successful leptogenesis with one L violating coupling and a relative Majorana phase playing the role of CP violation. This is in contrast to the usual consideration of Feynman diagram with at least two L violating couplings. We have considered R-parity violating minimal supersymmetric standard model (MSSM) for leptogenesis at TeV scale. This scenario is also consistent with generating light neutrino mass if asymmetry is generated through semileptonic $$\lambda ^{\prime }$$

λ
′

coupling.
3D topological quantum computing
Authors: Asselmeyer-Maluga Torsten 
Published: July 2021

In this paper, we will present some ideas to use 3D topology for quantum computing extending ideas from a previous paper. Topological quantum computing used “knotted” quantum states of topological phases of matter, called anyons. But anyons are connected with surface topology. But surfaces have (usually) abelian fundamental groups and therefore one needs non-Abelian anyons to use it for quantum computing. But usual materials are 3D objects which can admit more complicated topologies. Here, complements of knots do play a prominent role and are in principle the main parts to understand 3-manifold topology. For that purpose, we will construct a quantum system on the complements of a knot in the 3-sphere (see T. Asselmeyer-Maluga, Quantum Rep. 3 (2021) 153, arXiv:2102.04452 for previous work). The whole system is designed as knotted superconductor, where every crossing is a Josephson junction and the qubit is realized as flux qubit. We discuss the properties of this systems in particular the fluxion quantization by using the A-polynomial of the knot. Furthermore, we showed that 2-qubit operations can be realized by linked (knotted) superconductors again coupled via a Josephson junction.
4D Printing of Self-Folding Hydrogel Tubes for Potential Tissue Engineering Applications
Authors: Zhao Yu-Dong , Lai Jia-Hui , Wang Min 
Published: July 2021

In recent years, 4D printing has gained increasing attention in the tissue engineering field since this advanced manufacturing platform can create stimulus-responsive structures, which can change their shapes, functions, and/or properties when appropriate external stimulus/stimuli is/are applied. A number of hydrogels with swellable/shrinkable abilities have been explored for 4D printing to fabricate different shape-morphing structures for tissue engineering. Among them, gelatin methacryloyl (GelMA) has been 4D printed, which can self-fold into microtubular structures. Currently, the self-folding ability of 4D printed GelMA hydrogels is mainly based on the different cross-linking degrees (which control and govern the swelling degrees) across the thickness of hydrogels. However, this strategy alone can only form self-folding GelMA tubes with diameters at the micrometer level and cannot create self-folding GelMA tubes with diameters at the millimeter level, which is mainly due to the insufficient internal force generated in 4D printed GelMA hydrogels when they are exposed to water. To overcome this limitation, this study has investigated a new strategy to fabricate self-folding GelMA tubes with large diameters at the millimeter level for tissue engineering applications. The new strategy introduced a cross-linking degree gradient across the GelMA plane in addition to its thickness by printing a second layer of strips on the first 4D printed GelMA film. In the aqueous environment, under the current fabrication condition, such bilayer GelMA hydrogels could self-fold into tubes of larger diameters up to 6[Formula: see text]mm. The in vitro release behavior of heparin incorporated into the 4D printed GelMA was also studied. It was shown that heparin release could be controlled by the GelMA concentration and heparin content in 4D printed GelMA. The 4D printed GelMA hydrogels with the improved self-folding ability and controlled release of a drug are promising for targeted tissue engineering applications.
Prehistoric landscapes, humans and ostriches: highlighting geoarchaeological issues in the Tapi Basin of Maharashtra (west-central India) – a multidisciplinary approach
Authors: Sukumaran Prabhin , Li Hong-Chun , Lin Jih-Pai , Chauhan Parth R. 
Published: July 2021

Abstract
The formal beginning of geoarchaeology in India can be traced back to 1863 when the first palaeolith was documented and collected by Robert Bruce Foote in Tamil Nadu and later described in a detailed geological context. Today, various geological tools such as geospatial analytical tools are available to provide extra mileage to geoarchaeological investigations. They supplement field evidence and enable researchers to display, manipulate, and model geological data and the associated archaeological evidence. The present paper attempts to summarize the current status of understanding of the Quaternary geoarchaeology of the Tapi River basin in west-central India. The aspects considered include geomorphology, landform evolution, morphometric parameters, relationships between climate and basin evolution and Palaeolithic and Mesolithic evidence. This present study uses Landsat imagery, locational data, Survey of India topographic sheets and Shuttle Radar Topography Mission data in ArcGIS software. The study is the first comprehensive attempt to summarize the issue of prehistoric human adaptations (dominated mainly by Late Pleistocene evidence) through changing environments, with an assumption that the two occurred in synchronization. Another assumption is that the reported lithic and fossil sites and the surrounding areas have preserved signatures of original landforms and sedimentary contexts. Through these perspectives and visual integration of topography, drainage networks and Landsat image parameters in a Geographic Information System platform, along with other variable field inputs, a testable hypothetical model of the Quaternary evolution of Central Tapi valley is proposed. Additionally, an accelerator mass spectrometry (AMS) date of 47 145 cal BP for a newly discovered ostrich eggshell fragment from Sakegaon near Bhusawal is presented and its palaeoanthropological implications are discussed. Altogether, our observations from the study area, such as an expansion of land use from the Acheulean onwards, signatures of arid phases and the oldest reported ostrich eggshell, warrant further detailed multidisciplinary research. An in-depth understanding of the first-to-last occurrences of ostriches in the region and comprehensive picture of their pan-South Asian distribution in general will help address the issue of prehistoric human adaptations through changing environments.
Perspectives on Drug Development in Multiple Myeloma—Looking Forward to 2025
Authors: Voorhees Peter M. , Jakubowiak Andrzej J. , Kumar Shaji K. , Kanapuru Bindu , Baines Andrea C. , Bhatnagar Vishal , Ershler Rachel , Theoret Marc R. , Gormley Nicole J. , Pazdur Richard 
Published: July 2021

Abstract
The multiple myeloma treatment landscape has evolved considerably over the last 20 years with the development of multiple therapies with novel mechanisms of action and new combination regimens. However, the recent failure of several large phase III trials, coupled with an increased understanding of the mutational landscape of multiple myeloma has provided opportunities to explore optimal strategies for future multiple myeloma drug development. The Office of Oncologic Diseases at the FDA held an educational symposium, “Drug Development in MM-Project 2025,” in November 2019. The symposium brought together select U.S.-based academic thought leaders in the field of multiple myeloma to explore issues relevant to regulatory science in the field, including considerations for trial design, combination strategies, control arms, and precision medicine. This article summarizes the highlights of this educational symposium held at the FDA, including discussions on the future development of novel drugs and drug combinations and biomarker-directed therapies for patients with multiple myeloma.
A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop
Authors: Von Hoff Daniel D. , Clark Gary M. , Coltman Charles A. , Disis Mary L. , Eckhardt S.G. , Ellis Lee M. , Foti Margaret , Garrett-Mayer Elizabeth , Gönen Mithat , Hidalgo Manuel , Hilsenbeck Susan G. , Littlefield John H. , LoRusso Patricia M. , Lyerly H. Kim , Meropol Neal J. , Patel Jyoti D. , Piantadosi Steven , Post Dean A. , Regan Meredith M. , Shyr Yu , Tempero Margaret A. , Tepper Joel E. , Von Roenn Jamie , Weiner Louis M. , Young Donn C. , Vu Nu V. 
Published: July 2021

Abstract

To address the need for clinical investigators in oncology, American Association for Cancer Research (AACR) and American Society for Clinical Oncology (ASCO) established the Methods in Clinical Cancer Research Workshop (MCCRW). The workshop's objectives were to: (i) provide training in the methods, design, and conduct of clinical trials; (ii) ensure that clinical trials met federal and international ethical guidelines; (iii) evaluate the effectiveness of the workshop; and (iv) create networking opportunities for young investigators with mentoring senior faculty. Educational methods included: (i) didactic lectures, (ii) Small Group Discussion Sessions, (iii) Protocol Development Groups, and (iv) one-on-one mentoring. Learning focused on the development of an Institutional Review Board (IRB)-ready protocol, which was submitted on the last day of the workshop. Evaluation methods included: (i) pre- and postworkshop tests, (ii) students' workshop evaluations, (iii) faculty's ratings of protocol development, (iv) students' productivity in clinical research after the workshop, and (v) an independent assessment of the workshop. From 1996 to 2014, 1,932 students from diverse backgrounds attended the workshop. There was a significant improvement in the students' level of knowledge from the pre- to the postworkshop exams (P &lt; 0.001). Across the classes, student evaluations were very favorable. At the end of the workshop, faculty rated 92% to 100% of the students' protocols as ready for IRB submission. Intermediate and long-term follow-ups indicated that more than 92% of students were actively involved in patient-related research, and 66% had implemented five or more protocols. This NCI-sponsored MCCRW has had a major impact on the training of clinicians in their ability to design and implement clinical trials in cancer research.
Invasive Multimodal Neuromonitoring in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
Authors: Veldeman Michael , Albanna Walid , Weiss Miriam , Park Soojin , Hoellig Anke , Clusmann Hans , Helbok Raimund , Temel Yasin , Alexander Schubert Gerrit 
Published: July 2021

Background and Purpose:
Aneurysmal subarachnoid hemorrhage is a devastating disease leaving surviving patients often severely disabled. Delayed cerebral ischemia (DCI) has been identified as one of the main contributors to poor clinical outcome after subarachnoid hemorrhage. The objective of this review is to summarize existing clinical evidence assessing the diagnostic value of invasive neuromonitoring (INM) in detecting DCI and provide an update of evidence since the 2014 consensus statement on multimodality monitoring in neurocritical care.

Methods:

Three invasive monitoring techniques were targeted in the data collection process: brain tissue oxygen tension (p
ti
O
2
), cerebral microdialysis, and electrocorticography. Prospective and retrospective studies as well as case series (≥10 patients) were included as long as monitoring was used to detect DCI or guide DCI treatment.

Results:

Forty-seven studies reporting INM in the context of DCI were included (p
ti
O
2
: N=21; cerebral microdialysis: N=22; electrocorticography: N=4). Changes in brain oxygen tension are associated with angiographic vasospasm or reduction in regional cerebral blood flow. Metabolic monitoring with trend analysis of the lactate to pyruvate ratio using cerebral microdialysis, identifies patients at risk for DCI. Clusters of cortical spreading depolarizations are associated with clinical neurological worsening and cerebral infarction in selected patients receiving electrocorticography monitoring.

Conclusions:
Data supports the use of INM for the detection of DCI in selected patients. Generalizability to all subarachnoid hemorrhage patients is limited by design bias of available studies and lack of randomized trials. Continuous data recording with trend analysis and the combination of INM modalities can provide tailored treatment support in patients at high risk for DCI. Future trials should test interventions triggered by INM in relation to cerebral infarctions.