bluuebunny/crossref_metadata_2025_split huggingface dataset:
WATER HYACINTH: CLEARING THEM FROM KELAPA DUA LAKE AND UTILIZING THEM FOR HANDICRAFTS
Authors: Karnelasatri Karnelasatri - , Kurnia Rieswan Pangawira , Hardy Junius 
Published: March 2021

<p><em>Kelapa Dua Lake is important for the local community as a water catchment and reservoir. At certain times of the year, water hyacinth grown and spread rapidly due to the lake's high nutrient content, including nitrogen, phosphate, and potassium. These are indicators of pollution from the surrounding populated areas. Inappropriate and poorly timed countermeasures against this invasive species have had many negative effects. One countermeasure that could work, however, is harvesting the water hyacinth as a raw material for handicrafts. A joint team of lecturers, UPH service learning, students, a team from the National Disaster Management Agency (BNPB), the Indonesian local government, and local resident carried out a collaborative event to clear one section of Kelapa Lake of both water hyacinth and plastic waste. A numbers of water hyacinth were collected and then processed as a basic material for handicraft products. These handicraft products were then exhibited at an environmental education concert attended by invited guests, including representatives of the Kelapa Dua local government. This event is expected to provide new information about the processing and use of water hyacinth, highlighting its economic value and encouraging more positive activities to decrease water hyacinth and protect the environment.</em></p><p><strong>ABSTRACT (INDONESIAN):</strong> Danau Kelapa Dua merupakan danau yang sangat penting bagi masyarakat setempat sebagai tempat resapan dan tampungan air. Pertumbuhan eceng gondok di danau ini cukup cepat pada masa waktu tertentu karena adanya kemungkinan air danau yang memiliki kandungan nutrien tinggi seperti nitrogen, fosfat, dan potasium. Oleh sebab itu, invasi eceng gondok pada danau ini menjadi salah satu indikator pencemaran air dari berbagai aktivitas warga di sekitarnya. Penanggulangan yang terlambat dan kurang tepat terhadap invasi eceng gondok memberikan banyak dampak negatif. Salah satu pengontrolan invasi eceng gondok dapat dilakukan dengan memanfaatkannya sebagai bahan baku kerajinan tangan. Kegiatan gotong royong membersihkan eceng gondok dan sampah plastik pada salah satu area danau Kelapa Dua telah dilakukan oleh gabungan tim dosen, <em>service learning </em>UPH, mahasiswa dari berbagai jurusan, tim dari Badan Nasional Penanggulangan Bencana (BNPB), pemerintah dan warga setempat. Setelah kegiatan gotong royong, sejumlah eceng gondok yang dikumpulkan kemudian diolah sebagai bahan dasar produk kerajinan tangan. Berbagai produk kerajinan tangan kemudian dipamerkan pada konser musik edukasi lingkungan. Presentasi produk disaksikan oleh tamu-tamu undangan konser termasuk perwakilan pemerintah daerah Kelapa Dua. Kegiatan ini diharapkan dapat memberikan informasi baru tentang pengolahan eceng gondok agar bernilai ekonomis serta melakukan kegiatan positif untuk menjaga lingkungan.</p>
Impact of Influencers in Consumer Decision Process: The Fashion Industry
Authors: Nurfadila Siti 
Published: March 2021

The popularity of influencers is continuous and doesn’t have a limited window of influence. Internet and social media play vital role in helping consumers find the items they are looking for. Obviously companies will keenly try to retain a strong presence in the social media platforms; otherwise the target audience can easily change suppliers. The present study is intended to explore the influencer marketing techniques used by fashion industries and also the impact of influencers on the consumers buying decision process in fashion industry.
Esther Arroyo Amayuelas, Sergio Cámara Lapuente (Dir.). El Derecho privado en el nuevo paradigma digital
Authors: Santos Morón María José 
Published: March 2021

Este artículo reseña: Esther Arroyo Amayuelas, Sergio Cámara Lapuente (Dir.). El Derecho privado en el nuevo paradigma digital. Colegio Notarial de Cataluña, Marcial Pons, 2020, 536 págs. ISBN 978-84-9123-845-4
Foreword: 2019 International Collaborative Writing Groups (ICWGs)
Authors: Scharff Lauren , Divan Aysha , Motley Phillip 
Published: March 2021

Collaborative research and writing across disciplines and institutions happens frequently in discipline-based research. However, opportunities for cross-collaborative scholarship in teaching and learning is limited in comparison (Kahn et al., 2013; MacKenzie and Myers, 2012). Yet the value of larger scale, team-based approaches to scholarly writing is well recognised in building networks and in providing a deeper understanding of a topic as informed by multi-disciplinary and/or international perspectives (Marquis et al., 2014; 2015; Matthews et al., 2017). It is for these reasons that the International Collaborative Writing Groups (ICWG) program that crystallises around the International Society for the Scholarship of Teaching and Learning (ISSOTL) conference is so valuable. ICWGs bring together academics, professional staff, and students to co-author learning and teaching articles on topics of shared interest. The aims are two-fold: 1) to build capacity of participants to work and write with international collaborators, and 2) to contribute meaningful and topical perspectives to the SoTL literature.
Universal Health Coverage “Leave No Child Behind “
Authors: Siderius Liesbeth , Neubauer David , Bhattacharya Anjan , Altorjai Péter , Margvelashvili Lali , Lamabadusuriya Sanath , Wierzba Jolanta , Mazur Artur , Albrecht Piotr , Tasic Velibor 
Published: March 2021

Abstract
Aim: Multiple stakeholders are involved in achieving Universal Health Coverage (UHC) as part of the Sustainable Development Goals (SDG). The estimated over 90 million children with disabilities are among the most vulnerable members of the world’s population. Paediatricians around the world are united to promote a world where all children, regardless of their abilities or disabilities, can enjoy a healthy life and well-being. We examined: ‘What would be the least paediatricians could do to contribute to the UHC?’Methods: In cross-sectional study paediatricians, engaged in care for children with disabling and rare conditions, were questioned on eight of the UHC statements concerning child health, primary care services, availability and affordability of diagnostics and therapies and digital health; as well as country of residence and level of practice.Results: Responders from Europe and Israel, Asia and the US practice at primary-, secondary- and tertiary care level in high and middle economy countries. Promotion of paediatric primary care could reduce mortality and morbidity, according to 39/48 (81%) respondents. An active role of paediatricians in providing quality information would increase access to health services for children with disabilities, according to 40/48 (83%) responders. Improved data exchange is necessary to deliver primary care as a cornerstone, according to 38/48 (79%) responders. Respondents practising in middle economy countries reported significantly more frequently than their colleagues in high economies countries about “out of pocket” payments for diagnostics and therapies as well as reduced availability. In order to increase global awareness and international solidarity, a panel of participants in a paediatric network felt that paediatricians should undertake necessary actions to support the achievement of UHC.Conclusion: The economic gap in diagnostic and therapeutic facilities in paediatric practice should be considered in achieving UHC. An international paediatric network should support achieving the UHC by providing adequate paediatric training and quality (digital) information.
Robust prognostic signatures derived from proteomic panel profiling of plasma from patients with severe COVID-19 complications
Authors: Al-Nesf Maryam , Abdesselem Houari , Bensmail Ilham , Ibrahim Shahd , Saeed Walaa , Mohammed Sara , Razok Almurtada , Alhussain Hashim , Aly Reham , Maslamani Muna Al , Ouararhni Khalid , Khatib Mohamad , Hssain Ali Ait , Omrani Ali , Al-Kaabi Saad , Khal Abdullatif Al , Althani Asma , Samsam Waseem , Farooq Abdulaziz , Al-Suwaidi Jassim , Al-Maadheedh Mohammed , Al-Siddiqi Heba , Butler Alexandra , Decock Julie , Mohamed-Ali Vidya , Al-Ejeh Fares 
Published: March 2021

Abstract
COVID-19 complications present a huge burden on healthcare systems and warrant a predictive risk model for disease severity of SARS-CoV-2 infection to enable early intervention, prospective decision-making and triaging of patients. We profiled plasma proteins from COVID-19 patients (severe n=50, and mild n=50) and controls (n=50) using function- and pathway-based panels developed with the highly specific proximity extension assays. Several biological pathways were specific for patients with severe complications. Based on these dysregulated profiles, we propose candidate FDA-approved drugs that target multiple upregulated proteins to treat severe complications. In addition, the set of differentially expressed plasma proteins in severe disease contained a robust 46-protein signature, the COVID-19 molecular severity score, which predicts the risk of severe complications. We cross-validated this molecular severity score in an independent cohort and found it useful within three days after hospital admission to predict COVID-19 severity and outcomes. Associated with the molecular severity score, we identified a set of clinical parameters available at admission, that act as a clinical risk score for complications. The molecular and clinical risk scores described in our study may be prognostic tools for severe COVID-19 disease and help alleviate the pressure on healthcare systems during infection peaks.
Revealing the Transmission Dynamics of COVID-19: A Bayesian Framework for Rt Estimation
Authors: Yang Xian , Wang Shuo , Xing Yuting , Li Ling , Xu Richard Yi Da , Friston Karl , Guo Yike 
Published: March 2021

Abstract
In epidemiological modelling, the instantaneous reproduction number, Rt, is important to understand the transmission dynamics of infectious diseases. Current Rt estimates often suffer from problems such as lagging, averaging and uncertainties demoting the usefulness of Rt. To address these problems, we propose a new method in the framework of sequential Bayesian inference where a Data Assimilation approach is taken for Rt estimation, resulting in the state-of-the-art ‘DARt’ system for Rt estimation. With DARt, the problem of time misalignment caused by lagging observations is tackled by incorporating observation delays into the joint inference of infections and Rt; the drawback of averaging is improved by instantaneous updating upon new observations and a model selection mechanism capturing abrupt changes caused by interventions; the uncertainty is quantified and reduced by employing Bayesian smoothing. We validate the performance of DARt through simulations and demonstrate its power in revealing the transmission dynamics of COVID-19.
Efficacy of a Tailored Moisturizer for Reducing Chemotherapy-Induced Skin Dryness in Breast Cancer Patients: A Randomized Controlled Trial
Authors: Kang Danbee , Kim Nayeon , Im Young Hyuck , Park Yeon Hee , Kim Ji Yeon , Park Hyeokgon , Kim Eunjoo , Zhao Di , Guallar Eliseo , Ahn Jin Seok , Cho Juhee 
Published: March 2021

Abstract
Introduction: While up to 60% of breast cancer patients undergoing chemotherapy experience skin side effects reducing quality of life, it was unclear which individual product was beneficial. To evaluate the effectiveness of a tailored moisturizer with a high content (1.5%) of pseudo-ceramides on skin dryness due to chemotherapy in breast cancer patients. Methods: Randomized controlled trial conducted from February 2015 to October 2018. 204 breast cancer patients experiencing skin dryness after 1 cycle of chemotherapy were randomly assigned to 3 groups (tailored moisturizer with high pseudo-ceramide content; general moisturizer; and usual care). Skin dryness, dullness, quality of life, and changes in sebum level were assessed at baseline, 3 weeks, and 1 month after completion of chemotherapy. The primary objective of the trial was to compare the tailored moisturizer group to usual care.Results: At 1 month after completion of chemotherapy, the tailored moisturizer group was significantly less likely to report severe skin dryness compared to the usual care group (8.5 vs. 27.9%, respectively, P < 0.01). The tailored moisturizer group reported significantly lower levels of skin dullness and lower levels of impairment of dermatological quality of life compared with the other two groups. Conclusions: A tailored moisturizer with a high content of pseudo-ceramides improved skin dryness, dullness and dermatological quality of life compared to usual care in breast cancer patients undergoing chemotherapy.
Pair production tomography imaging
Authors: Lyu Qihui , Neph Ryan , Sheng Ke 
Published: March 2021

Abstract
X-ray Computed Tomography (CT) is an exceptionally versatile tool for diagnosis and detection. Despite numerous technological evolutions, the underlying mechanism for CT image formation has not changed. To markedly expand beyond the current capacity of X-ray CT based on a new image formation mechanism, we introduce pair production tomography (P2T) imaging. Unlike CT, whose signals arise from attenuation of the incident photons, P2T collects coincident annihilation photons originated from the pair production interaction with high energy X-rays for tomographic reconstruction. We studied three P2T acquisition methods, including filtered back projection (FBP), time-of-flight (TOF), and scanning pencil beam (SPB). Using Monte Carlo simulation on phantom and patient data, we demonstrate three distinctly new capabilities for P2T: high linearity with the material atomic number for element mapping and soft tissue differentiation, the ability to form tomography with as few as a single heavily truncated X-ray beam, and in vivo radiotherapy treatment dose verification and monitoring. Among the three P2T acquisition methods, FBP is the least technically demanding, but its utility is limited to high radiation dose procedures such as radiotherapy treatment monitoring. Both TOF and SPB result in high signal-to-noise ratio (SNR) P2T images with a typical imaging dose. The quality of TOF relies on the time resolution of detectors. In comparison, SPB suppresses localization errors based on the known excitation path, which significantly mitigates the detector time resolution requirement.
Numerical Analysis of Welded Branch Tube Operating in Creep Range
Authors: Jelwan Jad Antonios , Bassil Charbel 
Published: March 2021

Abstract
Pressure components used in energy and resources industries may be subjected to various damages including plasticity and creep. Life prediction of such components is an important consideration for engineers who design, build, or operate them. This paper aims to present a comprehensive study to investigate the problem of creep life assessment of a complex welded component containing multiple zones with different material properties unlike almost all of the previously developed methods that have been based on the secondary creep condition alone that cannot be considered as a true representative for the creep behaviour of materials. Thus, the necessary information to estimate the life of a branch tube based on the primary, secondary, and tertiary creep conditions are presented. Results confirm the experimental data from the literature producing the most conservative life.
Canada’s Response to International Travel During COVID-19 Pandemic – A Media Analysis&nbsp;
Authors: Re K Srikanth , Mithani Salima S. , Wilson Lindsay , Wilson Kumanan 
Published: March 2021

Abstract
Background The media play a critical role in informing the public about the pandemic. International travel is a highly contested subject in the media during the COVID-19 pandemic at both the international and national levels. We examined Canadian media reporting on international travel restrictions during the pandemic, how these restrictions aligned with the IHR (2005), and how the narrative around international travel evolved for the pandemic.MethodsWe analysed Canada’s top three national newspapers by circulation, namely – The Globe and Mail, The National Post and The Toronto Star, published between Jan 1, 2020 - May 31, 2020. Our search yielded a total of 378 articles across the three newspapers. Upon removing duplicates and screening the remaining articles, we included a total of 62 articles for the analysis. We conducted a qualitative media content analysis by using the inductive coding approach.ResultsThree major themes were identified within the articles. These included: 1) The role of scientific and expert evidence in implementing travel restrictions; 2) Federal legislation, regulations and enforcement of international travel measures; and 3) Compliance with WHO guidelines in travel restriction policy- and decision-making. The federal government relied on scientific evidence for implementing international travel restrictions. The federal government fully exercised its powers under the Quarantine Act to enforce travel regulations and comply with the IHR (2005). The government embraced rules-based international order by following WHO recommendations on international travel, contributing to delaying border closure and travel restrictions until mid-March.Conclusion The media focussed significantly on international travel related issues during the early phase of pandemic. The dominant media narrative remained the need for earlier travel restrictions against international travel.
An Integrative, Multi-parametric Approach for the Comprehensive Assessment of Microbial Quality and Pollution in Aquaculture Systems
Authors: Stabili Loredana , Salvo Marco Di , Alifano Pietro , Talà Adelfia 
Published: March 2021

Abstract
As the aquaculture sector significantly expanded worldwide in the past decades, the concept of sustainable aquaculture has developed with the challenge of not only maximizing benefits but also minimizing the negative impacts on the environment assuring, at the same time, food security. In this framework monitoring and improving the microbiological water quality and animal health is a central topic. In the present study, we evaluated the seawater microbiological quality in a mariculture system located in a Mediterranean coastal area (Northern Ionian Sea, Italy). We furnished, for the first time, a microbial inventory based on conventional culture-based methods, integrated with the 16S rRNA gene metabarcoding approach for vibrios identification and diversity analyses, and further implemented with microbial metabolic profiling data obtained from the Biolog EcoPlate system. Microbiological pollution indicators, vibrios diversity, and microbial metabolism were determined in two different times of the year (July and December). All microbial parameters measured in July were markedly increased compared to those measured in December. The presence of potentially pathogenic vibrios is discussed concerning the risk of fish disease and human infections. Thus, the microbial inventory here proposed might represent a new multi-parametric approach for the suitable surveillance of the microbial quality in a mariculture system. Consequently, it could be useful for ensuring the safety of both the reared species and the consumers in the light of sustainable, eco-friendly aquaculture management.
Tapping Span Test as a Simple Diagnostic Tool for Patients With Initial-stage Posterior Cortical Atrophy: Short Tapping Span Length Indicates Visuospatial Working Memory Dysfunction
Authors: Funayama Michitaka , Takata Taketo , Nakagawa Yoshitaka , Sunagawa Kosaku , Nakajima Asuka , Kawashima Hiroaki , Mimura Masaru 
Published: March 2021

Abstract
Posterior cortical atrophy is a rare degenerative condition with prominent visuospatial dysfunction which commonly occurs between ages 50 and 65. A diagnosis of posterior cortical atrophy during its initial stage is sometimes challenging and can be delayed because there are currently no established neuropsychological examination methods that can easily be used in clinical settings. In this study, we examined whether the tapping span test is a potential diagnostic tool for posterior cortical atrophy and what impairment the tapping span test is indicative of in this condition. Eight patients with initial-stage posterior cortical atrophy were recruited. Age- and severity-matched individuals with amnesic Alzheimer’s disease (n = 9) were also recruited as a control group. The participants were subjected to the tapping span test and several visuospatial working memory tests. The results of the tapping span and visuospatial working memory tests were worse for the posterior cortical atrophy group when compared with the control group. The results from the tapping span tests were strongly correlated with those from the visuospatial working memory tests. The tapping span test is a simple and potentially useful diagnostic tool for patients with initial-stage posterior cortical atrophy, as it reflects visuospatial working memory function.
Bromine domain protein 4 is an important marker for prognosis of ovarian cancer and tumor immune infiltration
Authors: Chen Chujia , Yang Zhiyong , Zhao Qiuchan , Xu Bangming , Cao Donglin 
Published: March 2021

Abstract
Background

Ovarian cancer (OC) is one of the most common malignant gynecological tumors, but its pathogenesis is unclear. Bromine domain protein 4 (BRD4) is involved in the malignant transformation of cells, as well as the invasion and metastasis of tumor cells. The biological role of BRD4 in ovarian cancer is yet to be determined.
Methods

The differential expression of BRD4 in OC and corresponding normal tissues was evaluated by exploring the Tumor Immune Assessment Resources (TIMER) and the Oncomine database. The correlation between the expression level of BRD4 and the prognosis of OC patients was evaluated using the Kaplan-Meier Plotter database. Using TIMER, we further studied the correlation between BRD4 and tumor immune cell infiltration.
Results

The expression of BRD4 was significantly higher in patients with OC, and high BRD4 expression was closely related to low overall survival rate. The BRD4 expression was associated with the levels of immune markers of macrophages, dendritic cells, neutrophils, and various effector T cells. Taken together, these findings show that BRD4 expression is significantly related to immune infiltration in OC and suggest that BRD4 might play an important role in the immune evasion of OC cells.
Conclusion

The expression level of BRD4 in OC tissues is significantly upregulated, and its high expression is significantly associated with poor prognosis of patients and is closely related to tumor immune infiltration. These results suggest that BRD4 can be used as a prognostic marker and a marker of immune infiltration in OC.