bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Stylet Angulation at the Holding Position During Tracheal Intubation with a Videolaryngoscope: A Randomized Controlled Trial
Authors: Wakabayashi Ryo , Shiko Yuki , Kodaira Tomofumi , Shiroshita Yuko , Otsuka Hitomi , Baba Kosuke , Hishinuma Norimasa 
Published: July 2021

Abstract
The aim of this randomized controlled trial was to determine the efficacy of stylet angulation at the holding position during tracheal intubation with a McGRATH™ MAC videolaryngoscope. Patients were randomized to a group for intubation without stylet angulation at the holding position (non-angulation group) and to a group for intubation with stylet angulation at the holding position (angulation group). The primary outcome was the time for placement of the tracheal tube. Sixty patients were analyzed. The mean (standard deviation) times for tube placement were 21.3 (5.6) s in the non-angulation group and 16.9 (3.8) s in the angulation group (P < 0.001). The scores of operator's perception of difficulty in tube delivery, number of attempts for tube delivery, and degrees of extension, abduction, internal rotation of the right upper arm and extension of the right wrist during tube placement in the angulation group were significantly smaller than those in the non-angulation group (P < 0.001, P = 0.002, P < 0.001, P < 0.001, P < 0.001, P < 0.001, respectively). Our results suggest that stylet angulation at the holding position improves maneuverability of the tracheal tube and enables easy tube placement during tracheal intubation with a McGRATH™ MAC videolaryngoscope.
Clinical Practice Guideline for End-of-Life Care in Patients with Cancer: A Modified ADAPTE Process
Authors: Irajpour Alireza , hashemi maryam , Taleghani Fariba 
Published: July 2021

Abstract
PurposeThis study seeks to adapt a guideline for end-of-life care in patients with cancer to be used by healthcare teams.MethodsThis methodological study was conducted by modifying the ADAPTE process and adding to it a qualitative study and consensus ratings by a multidisciplinary panel of experts. A qualitative study was thus performed to identify the end-of-life needs of patients with cancer. Then, the source guidelines and the results of the qualitative study were used to draft the initial version of the guideline, with 85 adaptation recommendations. A multidisciplinary panel of healthcare experts performed the external review of the recommendations based on the four criteria of relatedness, comprehensibility, usefulness, and feasibility and scored them on a scale of 1-9. The mean score of each recommendation was calculated, and the recommendations were classified into three categories: Appropriate (mean score of 7-9), uncertain (mean score of 4-6.99), and inappropriate (mean score of 1-3.99).ResultsAll the recommendations were approved, as they all had a mean score of 7 or higher, and were then categorized into 11 dimensions: Communication management; participatory and evidence-based decision-making management; pain management; dyspnea management; nausea and vomiting management; anorexia and cachexia management; constipation management; death rattle management; management of delirium, anxiety, and restlessness; hydration management; and pharmacological considerations.ConclusionThe adaptation of the guideline for end-of-life care in patients with cancer in Iran was performed by modifying the ADAPTE process with the participation of multidisciplinary stakeholders and based on the local needs.
Extracurricular Activity on Music and Visual Art Associates with Children’ Academic Achievement by Transferring Each Subject Score
Authors: Ishiguro Chiaki , Ishihara Toru , Morita Noriteru 
Published: July 2021

Abstract
The present longitudinal study examined whether extracurricular activities in the arts have a positive association with general academic performance, which is mediated by improved art scores. Data was collected from 700 seventh-grade children (379 boys and 321 girls) for over three years. Information regarding their participation in extracurricular activities in music and visual arts, grade points in general academic performance (i.e., Japanese, Social Studies, Mathematics, Science, and English), music, and arts were obtained, at the end of the seventh and ninth grades. Structural equation modeling revealed that both participation in extracurriculars in music and visual arts was positively associated with improvements in general academic performance from seventh to ninth grade, and these associations were mediated by improvements in music and visual arts scores. This finding suggests that arts education can contribute to improving general academic performance.
Exploration of Core Genes Signature and Prognostic Implication for Ductal Carcinoma In Situ of the Breast
Authors: Zhang Jiao , Lin Hui , Hou Lei , Xiao Hui , Gong Xilong , Guo Xuhui , Cao Xuchen , Liu Zhenzhen 
Published: July 2021

Abstract
Background: Following the implementation of breast screening programs, the occurrence of DCIS has risen as an early form of neoplasm. Although the prognosis is good, 20-50% of DCIS patients will develop invasive ductal carcinoma (IDC) if they are not handled. It is important to look for promising biomarkers for predicting DCIS prognosis.Methods: The Gene Expression Omnibus (GEO) database provided three microarray profile datasets. The expression of genes that differed between DCIS and normal tissue was investigated. To describe the biological role and intrinsic process pathway, enrichment analysis was used. The Cancer Genome Atlas Breast Cancer Dataset was used to classify the hub genes and further verify the findings using CytoHubba and MCODE, two Cytoscape plugins. The prognostic ability of the core genes signature was determined through time-dependent receiver operating characteristic (ROC), Kaplan-Meier survival curve, Oncomine databases, and UALCAN databases. In addition, in proliferation assays, the prognostic value of core genes was verified.Results: We identified 217 common DEGs, with 101 up-regulated and 138 down-regulated genes in the present study. The top genes were obtained from the PPI network (protein-protein interaction). For DCIS prognosis prediction, a novel six gene signature (including GAPDH, CDH2, BIRC5, NEK2, IDH2, and MELK) was developed. Centered on the TCGA cohort, the ROC curve showed strong results in prognosis prediction. The six core genes signature is often overexpressed in DCIS, which has a weak prognosis. Furthermore, transfected with small interfering RNAs, downregulation of core gene expression significantly inhibits breast cancer cell proliferation, implying a great potential for using core genes in DCIS prognosis.Conclusions: The six core genes signature for promising DCIS biomarkers was validated in our research, which may assist in clinical decision-making for individual care.
Comparison of OSCE Performance Between 6- and 7-Year Medical School Curricula in Taiwan
Authors: Wu Jr-Wei , Cheng Hao-Min , Huang Shiau-Shian , Liang Jen-Feng , Huang Chia-Chang , Yang Ling-Yu , Shulruf Boaz , Yang Ying-Ying , Chen Chen-Huan , Hou Ming-Chih , Sheu Wayne Huey-Herng 
Published: July 2021

Abstract
BackgroundThe year 2013 marks a watershed in the history of medical education in Taiwan. Following Taiwan's Taskforce of Medical School Curriculum Reform recommendations, the medical school curriculum was reduced from 7 to 6 years. This study aimed to analyze the impact of medical school curriculum reform on medical students' performance in objective structured clinical examinations (OSCEs). MethodsWe retrospectively analyzed the OSCE records at Taipei Veterans General Hospital (Taipei VGH), one of Taiwan's largest tertiary medical centers, between November 2016 and July 2020. The eligibility criteria were medical students receiving a full one-year clinical internship training at Taipei VGH and in their last year of medical school. All medical students received a mock OSCE-1 at the beginning of their internship, a mock OSCE-2 after six months of training, and a national OSCE at the end of their internship. The parameters for performance in OSCEs included “percentage of scores above the qualification standard” and “percentage of qualified stations.” ResultsBetween November 2016 and July 2020, 361 undergraduates underwent clinical internship training at Taipei VGH. Among them, 218 were taught under the 7-year curriculum, and 143 were instructed under the 6-year curriculum. Based on baseline-adjusted ANCOVA results, medical students under the 7-year curriculum had a higher percentage of scores above the qualification standard than those under the 6-year curriculum at the mock OSCE-1 (7-year curriculum vs. 6-year curriculum: 33.8% [95% CI 32.0–35.7] vs. 28.2% [95% CI 25.9–30.4], p<0.001), and mock OSCE-2 (7-year curriculum vs. 6-year curriculum: 89.4% [95% CI 87.4–91.4] vs. 84.0% [95% CI 81.5–86.4], p=0.001). Moreover, medical students in the 7-year curriculum had a higher percentage of qualified stations in mock OSCE-1 (7-year curriculum vs. 6-year curriculum: 89.4% [95% CI 87.4–91.4] vs. 84.0% [95% CI 81.5–86.4], p=0.001) and mock OSCE-2 (7-year curriculum vs. 6-year curriculum: 91.9% [95% CI 90.1–93.8] vs. 86.1% [95% CI 83.8–88.3], p=0.001). After clinical internship training, there were no differences in the percentage of scores above the qualification standard (7-year curriculum vs. 6-year curriculum: 33.5% [95% CI 32.2–34.9] vs. 34.6 [95% CI 32.9–36.3], p=0.328) and percentage of qualified stations (7-year curriculum vs. 6-year curriculum: 89.4% [95% CI 88.1–90.7] vs. 90.2% [95% CI 88.6–91.8], p=0.492). ConclusionsAt the beginning of the internship, medical students under the 7-year curriculum had better OSCE performance than those under the 6-year curriculum. After the clinical internship training in Taipei VGH, there was no difference in the national OSCE score between the 6- and 7-year curricula. Our study suggests that clinical internship is crucial for the development of clinical skills and performance in the national OSCE.
Aspect Dependent-based Ghost Suppression for Extended Targets in Through-the-wall Radar Imaging under Compressive Sensing Framework
Authors: Rambika Mugundu , Abdalla Abdi , Amour Idrissa , Maiseli Baraka Jacob , Mwambela Alfred 
Published: July 2021

Abstract
Several approaches have been proposed to suppress multipath ghost in through-the-wall radar imaging (TWRI). One classical approach, called Aspect Dependent (AD), exploits locations of ghosts in the images without demanding prior knowledge of the reflecting geometry. This operation strategy makes the method superior over multipath exploitation-based approaches. However, the AD method assumes a point target that emulates unreal environment. Therefore, reconstructing extended targets with this method leads to incorrect scene interpretation. This work proposes a ghost suppression method for extended targets based on the AD feature that exploits duo sub-apertures. Firstly, we evaluate the best suppression method using a performance metric called relative clutter peak. Next, the evaluated method is extended to encompass the target extent during sub-images reconstruction. Following this strategy, an effective image fusion method suitable for extended targets is proposed. The method considers pixel neighborhood to effectively recover the given extended target. Simulation results show that the proposed method significantly improves signal-to-clutter ratio and relative clutter peak by 8.8% and 23.8%, respectively, relative to the existing AD based methods under point target assumption.
Heart failure in childhood cancer survivors – A systematic review protocol
Authors: Berg Tove , Böhmer Jens , Nwaru Bright , Karason Kristjan , Jarfelt Marianne 
Published: July 2021

Abstract
BackgroundOver the past decades, survival rate for childhood cancer has greatly improved. However, the risk of late cardiac complications after such treatment remains high. Previous studies have shown that the risk for heart failure among childhood cancer survivors is significantly higher than that observed in the general population. The aim of this systematic review is to identify, critically appraise and synthesize existing population-based studies reporting on the frequency of heart failure, both incidence or prevalence, that may develop after treatment of childhood cancer.Method:The following databases will be searched from their inception date until May 17th 2021: Medline, Embase, Scopus, CINAHL, CAB International, AMED, Global Health, Psycinfo, Web of science and Google Scholar. Population-based studies reporting on the incidence and/or prevalence of heart failure after treatment of any type of childhood cancer will be included. Screening of articles, data extraction and quality assessment will be performed independently by two reviewers. The quality and risk of bias in the studies included will be assessed by using the Effective Public Health Practice Project tool. A narrative synthesis of the extracted data will be undertaken and, for studies that are sufficiently homogenous, a meta-analysis using random-effects models performed.DiscussionThis systematic review will provide a clearer picture of the epidemiology of heart failure after treatment of childhood cancer. Collected data will be of value for future childhood cancer treatment protocols and also offer guidance for post-treatment cardiac surveillance among survivors.Systematic review registrationThis protocol follows the structure of the recommendation of the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) and has been submitted in PROSPERO on April 28th 2021, awaiting assignment of registration number.
Combination of Texture and Shape Features Using Machine and Deep Learning Algorithms for Breast Cancer Diagnosis
Authors: Gargouri Norhene , Mokni Raouia , Damak Alima , Sellami Dorra , Abid Riadh 
Published: July 2021

Abstract
Worldwide, breast cancer is a commonly occurring disease in women. Automatic diagnosis of the lesions based on mammographic images is playing an essential role to assist experts. A novel Computer-Aided Diagnosis (CADx) scheme of breast lesion classification is proposed in this paper based on an optimized combination of texture and shape features using machine and deep learning algorithms for mass classification as benign-malignant namely C(M-ZMs)*.
The main advantage of using Zernike moments for shape feature extraction is their scale, translation, and rotation invariance property, this allows omitting some of the preprocessing stages in our case. We implemented for texture feature extraction the Monogenic-Local Binary Pattern taking the advantage of lower time and space complexity because monogenic signal analysis needs fewer convolutions and generates more compact feature vectors. Therefore, we used Zernike moments for shape feature extraction due to their scale, translation, and rotation invariance property, this allows omitting some of the preprocessing stages in our proposed system.
The proposed system proves its performance on some challenging breast cancer cases where the lesions exist in dense breast tissues. Validation has been undertaken on 520 mammograms from the Digital Database for Screening Mammography Database (DDSM), yielding an accuracy rate of 99.5\%.
Evaluating the Influences of Urban Expansion on the Concurrent Loss of Multiple Ecosystem Services in Drylands
Authors: Song Shixiong , He Chunyang , Liu Zhifeng , Qi Tao 
Published: July 2021

Abstract
Context Effectively estimating the influences of urban expansion on multiple ecosystem services (ESs) is of great importance for improving urban planning in drylands. However, there are some shortcomings in the existing urban expansion models, which lead to great uncertainties in the assessment of the influences of urban expansion on the concurrent loss of multiple ESs.Objectives This study sought to effectively estimate the influences of urban expansion on the concurrent loss of multiple ESs in drylands.Methods We combined the improved the urban expansion model and ES models to estimate the influences of urban expansion on five key ESs, including food production (FP), water retention (WR), air quality regulation (AQR), natural habitat quality (NHQ), and landscape aesthetic (LA).Results The results showed that (1) our method can effectively evaluate the influences of urban expansion on the concurrent loss of multiple ESs in drylands, and the accuracy increased by more than 20% on average. (2) Under the effect of future urban expansion, FP, WR, AQR, NHQ and LA will accelerate the decline. (3) These five ESs will show concurrent degradation, and the degree will be further intensified. (4) Future urban expansion will occupy more cropland and grassland which will be the dominating reason for the intensified degradation of multiple ESs. Conclusions We suggest that urban expansion through occupying a large amount of cropland and grassland should be strictly controlled via urban land planning to alleviate the potential influences of future urbanization on the concurrent loss of multiple ESs.
Personalized Model Predictive Control for Artificial Pancreas
Authors: Wang Weijie , Wang Shaoping , Zhang Yuwei , Geng Yixuan 
Published: July 2021

Abstract
This paper proposes a personalized model predictive control strategy for the artificial pancreas to guide insulin injection in diabetic therapy. To overcome the parameter uncertainty induced by inter and intra-individual variability, a new observable glucose-insulin dynamic model is established to describe the integrated metabolism of glucose and insulin, under which all model parameters can be extended to observable state variables. Subsequently, a particle filtering estimator is developed to identify not only the personalized parameters, but also the plasma glucose concentration. Concerning the time delay of glucose metabolism, model predictive control is employed to regulate the glucose concentration in plasma, instead of glucose concentration measured in interstitial tissue using continuous glucose monitor. For validation, the experiments are carried out on the 30 in-silico subjects produced by UVa/Padova simulator. The proposed algorithm shows promising performances on personalized identification and plasma glucose control (mean value of 6.64 mmol/L) without meal announcement. It shows that the proposed method has the potential for artificial pancreas in clinical treatment.
Reduction of SARS-CoV-2 Infectious Titers by Direct Contact with Cuprous-Oxide Impregnated Face Masks External Layers
Authors: Xu Wei , Gu Chenjian , Wang Qin , Lin Yanfan , Zhang Chi , Borkow Gadi 
Published: July 2021

Abstract
SARS-CoV-2 can remain viable on the protective face masks surface for several days. Mask touching, reuse and disposal occurs frequently, leading to increased risk of cross-contamination, infection and further transmission. Cuprous-oxide has potent virucidal properties. We determined the capacity of surgical face masks (type IIR) made with nonwoven fabric impregnated with cuprous-oxide microparticles (Test Fabric), to inactivate SARS-CoV-2 when in direct contact with the virus. The Test Fabric reduced the infectious titers of SARS-CoV-2 by 0.73, 3.02 and 4.19 log10 within 5, 30 and 60 minutes, respectively. In contrast, the infectious titers of the virus were reduced by Control Fabric by 0.24, 0.67 and 0.97 within 5, 30 and 60 minutes, respectively. The reductions were significantly higher in the Test Fabric than in the Control Fabric (0.49, 2.35 and 3.22 log difference, accordingly), reaching a statistically significant difference after 5 minutes (p < 0.01). The mask filtration properties were not affected by the presence of the cuprous oxide microparticles. We conclude that the use of cuprous-oxide containing face masks in the external layers of respiratory face masks may significantly reduce the risk of SARS-CoV-2 cross-contamination, transmission and infection, due to masks handling and disposal, especially when used by the general population.
The Relationship between Nutrition and Cancer in Elderly Hospitalized Patients: A Retrospective Chart Analysis
Authors: Yang Lina , Wu Lan 
Published: July 2021

Abstract
Background: The purpose of the present study was to retrospectively analyze the relationship between nutrition and cancer in elderly hospitalized patients. Methods: A total of 339 elderly patients were divided into cancer and non-cancer groups. Information regarding nutritional blood parameters (NBP), including TP, ALB, PA, TLC, and Hb; nutritional risk screening (NRS), including ADL, MNA-SF, WST; and polypharmacy was collected and analyzed.Results: Among the 339 patients, 94 (27.7%) were women, 81 (23.9%) were cancer patients, and 258 (76.1%) were non-cancer patients. Overall, 25.3% of patients were malnourished. Patients in the cancer group were younger, with higher rates of inflammation, lower rates of polypharmacy and swallow dysfunction, increased ADL, and decreased MNA-SF score. The BMI, TP, PA, Hb, and TLC were notably decreased in cancer patients. The MNA-SF score had a positive correlation with BMI, TP, ALB, PA, Hb, TLC, and ADL, but a negative correlation with CRP, WST score, polypharmacy, and age. Conclusion: There was a close relationship between nutritional status and cancer in elderly patients. Geriatric patients with cancer were more prone to a poor nutritional status. Nutritional screening, assessment, and intervention should be increased to improve the prognosis in cancer patients.
Potential Prognostic and Therapeutic Target of CDC7 in Hepatocellular Carcinoma
Authors: Liu Runze , Gan Lu , Zhang Zhikun , Liu Xiuli , Zhong Liping , Zhao Yongxiang , Huang Yong 
Published: July 2021

Abstract
Background: Hepatocellular carcinoma (HCC) remains difficult to treat, owing to the lack of effective predictor and therapeutic targets. CDC7 is a critical gene that regulates cell cycle and highly expressed in patients with HCC. However, it remains unclear whether the expression levels of CDC7 predict survival for patients with HCC and direct impact on the tumor immune microenvironment (TIME). Methods: We then downloaded CDC7 expression and clinical characteristics from public databases and used R language and tools online for statistical analysis and graphical work. Results: Multivariate analyses showed that both high CDC7 expression and low immune scores was strongly correlated with worse disease-free survival (DFS) and overall survival (OS). CDC7 expression was positively correlated with infiltrating levels of CD4+ T cells, macrophages, dendritic cells (DCs) and M2 macrophages in HCC. Interestingly, analyses showed the high CDC7 expression was also closely related to the genes which contribute to HCC metastasis. Conclusions: Our study now, for the first time, provides an explanation of CDC7 with clinical characteristics and immune-related factors. High CDC7 expression might promote HCC metastasis and M2-polarized macrophages resulted in a poor prognosis. The predicting nomograms may help to estimate the survival of patients.