bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response to crowded conditions reveals compact nucleus for amyloid formation of folded protein
Authors: Werner Tony E.R. , Horvath Istvan , Wittung-Stafshede Pernilla 
Published: January 2021

AbstractAlthough the consequences of the crowded cell environments may affect protein folding, function and misfolding reactions, these processes are often studied in dilute solutions in vitro. We here used biophysical experiments to investigate the amyloid fibril formation process of the fish protein apo-β-parvalbumin in solvent conditions that mimic steric and solvation aspects of the in vivo milieu. Apo-β-parvalbumin is a folded protein that readily adopts an amyloid state via a nucleation–elongation mechanism. Aggregation experiments in the presence of macromolecular crowding agents (probing excluded volume, entropic effects) as well as small molecule osmolytes (probing solvation, enthalpic effects) revealed that both types of agents accelerate overall amyloid formation, but the elongation step was faster with macromolecular crowding agents but slower in the presence of osmolytes. The observations can be explained by the steric effects of excluded volume favoring assembled states and that amyloid nucleation does not involve monomer unfolding. In contrast, the solvation effects due to osmolyte presence promote nucleation but not elongation. Therefore, the amyloid-competent nuclei must be compact with less osmolytes excluded from the surface than either the folded monomers or amyloid fibers. We conclude that, in contrast to other amyloidogenic folded proteins, amyloid formation of apo-β-parvalbumin is accelerated by crowded cell-like conditions due to a nucleation process that does not involve large-scale protein unfolding.
COMPARING DIRECT CARBONATE AND STANDARD GRAPHITE 14C DETERMINATIONS OF BIOGENIC CARBONATES
Authors: Bright Jordon , Ebert Chris , Kosnik Matthew A , Southon John R , Whitacre Katherine , Albano Paolo G , Flores Carola , Frazer Thomas K , Hua Quan , Kowalewski Michal , Martinelli Julieta C , Oakley David , Parker Wesley G , Retelle Michael , do Nascimento Ritter Matias , Rivadeneira Marcelo M , Scarponi Daniele , Yanes Yurena , Zuschin Martin , Kaufman Darrell S 
Published: January 2021

ABSTRACTThe direct carbonate procedure for accelerator mass spectrometry radiocarbon (AMS 14C) dating of submilligram samples of biogenic carbonate without graphitization is becoming widely used in a variety of studies. We compare the results of 153 paired direct carbonate and standard graphite 14C determinations on single specimens of an assortment of biogenic carbonates. A reduced major axis regression shows a strong relationship between direct carbonate and graphite percent Modern Carbon (pMC) values (m = 0.996; 95% CI [0.991–1.001]). An analysis of differences and a 95% confidence interval on pMC values reveals that there is no significant difference between direct carbonate and graphite pMC values for 76% of analyzed specimens, although variation in direct carbonate pMC is underestimated. The difference between the two methods is typically within 2 pMC, with 61% of direct carbonate pMC measurements being higher than their paired graphite counterpart. Of the 36 specimens that did yield significant differences, all but three missed the 95% significance threshold by 1.2 pMC or less. These results show that direct carbonate 14C dating of biogenic carbonates is a cost-effective and efficient complement to standard graphite 14C dating.
Comparison of two criteria on the essential number calculation of Andrena camellia
Authors: Huang Dunyuan , Kou Ruomei , Orr Michael C. , Li Hongying , Dou Feiyue , Zhu Chaodong 
Published: January 2021

AbstractAndrena camellia Wu is one of the primary pollinators of Camellia oleifera A. in China. In this paper, the essential number of individuals for efficient pollination by this species was calculated via two criteria, based on various indicators including counts of pollen grains in provisions, from single visits, and from single foraging trips overall; single flower visit duration; single flight period duration; number of eggs laid by a single female over their lifetime; and the average number of flowers per plant. Based on the number of pollen grains collected per flower visit, the essential number of females necessary is 2107 in a 1-ha Camellia oleifera garden with 1800 plants, while only 1998 female individuals are essentially needed when estimated based on the mean number of pollen grains collected in a single flight period. We argue that the essential number estimated by the former method is more reasonable and accurate for practical applications.
Modelling of post-diapause development and spring emergence of Cydia nigricana (Lepidoptera: Tortricidae)
Authors: Riemer Natalia , Schieler Manuela , Racca Paolo , Saucke Helmut 
Published: January 2021

AbstractThe prediction of the post-diapause emergence is the first step towards a comprehensive decision support system that can contribute to a considerable reduction of pesticide use by forecasting a precise spraying date. The cumulative field emergence can be described as a function of the cumulative development rate. We investigated the impact of seven constant temperatures and five light regimes on post-diapause development in laboratory experiments. Development rate depended significantly on temperature but not on photoperiod. We therefore fit non-linear thermal performance curves, a better and more modern approach over past linear models, to describe the development rate as a function of temperature. The four parameter Brière function was the most suitable and was subsequently applied to temperature data from 36 previous pea fields, where pea moth emergence was measured with pheromone traps in Northern Hesse (Germany). In order to describe the variation in development times between individuals, we fit five nonlinear distribution models to the cumulative development rate as a function of cumulative field emergence. The three parameter Gompertz model was selected as the best fitted model. We validated the model performance with an independent field data set. The model correctly predicted the first moth in the trap and the peak emergence in 81.82% of cases, with an average deviation of only 2.00 and 2.09 days respectively.
Fertility transition and socioeconomic development in districts of India, 2001–2016
Authors: Chatterjee Sayantani , Mohanty Sanjay K. 
Published: January 2021

AbstractThe fertility–development relationship is bi-directional, context-specific, multi-phased and inconsistent over time. Indian districts provide an ideal setting to study this association due to their size, diversity and disparity in socioeconomic development. The objective of this study was to understand the association of fertility and socioeconomic development among the 640 districts of India. Data were drawn from multiple sources: Censuses of India 2001 and 2011; DLHS-2; NFHS-4; and other published sources. A district-level data file for Total Fertility Rate (TFR) and a set of developmental indices were prepared for the 640 districts for 2001 and 2016. Computation of a composite index (District Development Index, DDI), Ordinary Least Squares, Two Stage Least Squares and panel regressions were employed. By 2016, almost half of all Indian districts had attained below-replacement fertility, and 15% had a TFR of above 3.0. The DDI of India increased from 0.399 in 2001 to 0.511 by 2016 and showed large variations across districts. The correlation coefficient between TFR and DDI was –0.658 in 2001 and –0.640 in 2016. Districts with a DDI of between 0.3 and 0.6 in 2001 had experienced a fertility decline of more than 20%. The fertility–development relationship was found to be strongly negative, convex and consistent over time, but the level of association varied regionally. For any given level of DDI, fertility in 2016 was lower than in 2001; and the association was stronger in districts with a DDI below 0.45. The negative convex association between the two was prominent in the northern, central and eastern regions and the curves were flatter in the west, south and north-east. The increasing number of districts with low fertility and low development draws much attention. Some outlying districts in the north-eastern states had high TFR and high DDI (>0.6). Based on the findings, a multi-layered strategy in districts with low socioeconomic development is recommended. Additional investment in education, child health, employment generation and provisioning of contraceptives would improve the human development to achieve India’s demographic goals.
Theory and predictions for the development of morphology and syntax: A Universal Grammar + statistics approach
Authors: Pearl Lisa 
Published: January 2021

AbstractThe key aim of this special issue is to make developmental theory proposals concrete enough to evaluate with empirical data. With this in mind, I discuss proposals from the “Universal Grammar + statistics” (UG+stats) perspective for learning several morphology and syntax phenomena. I briefly review why UG has traditionally been part of many developmental theories of language, as well as common statistical learning approaches that are part of UG+stats proposals. I then discuss each morphology or syntax phenomenon in turn, giving an overview of relevant UG+stats proposals for that phenomenon, specific predictions made by each proposal, and what we currently know about how those predictions hold up. I conclude by briefly discussing where we seem to be when it comes to how well UG+stats proposals help us understand the development of morphology and syntax knowledge.
Neurosciences in the Third Reich: from Ivory Tower to Death Camps
Authors: Shevell Michael I. 
Published: January 2021

Abstract:It is commonly thought that the horrific medical abuses occurring during the era of the Third Reich were limited to fringe physicians acting in extreme locales such as the concentration camps. However, it is becoming increasingly apparent that there was a widespread perversion of medical practice and science that extended to mainstream academic physicians. Scientific thought, specifically the theories of racial hygiene, and the political conditions of a totalitarian dictatorship, acted symbiotically to devalue the intrinsic worth to society of those individuals with mental and physical disabilities. This devaluation served to foster the medical abuses which occurred. Neurosciences in the Third Reich serves as a backdrop to highlight what was the slippery slope of medical practice during that era. Points on this slippery slope included the “dejudification” of medicine, unethical experimentation in university clinics, systematic attempts to sterilize and euthanasize targeted populations, the academic use of specimens obtained through such programs and the experimental atrocities within the camps.
The influence of prescriber and patient gender on the prescription of benzodiazepines: results from the Florida Medicaid Dataset
Authors: Lui Leanna M. W. , Lee Yena , Lipsitz Orly , Rodrigues Nelson B. , Gill Hartej , Ma Jifeng , Wilkialis Linas , Tamura Jocelyn K. , Siegel Ashley , Chen-Li David , Rosenblat Joshua D. , Mansur Rodrigo B. , McPherson Marie A. , McIntyre Roger S. 
Published: January 2021

AbstractBackgroundBenzodiazepine (BZD) prescription rates have increased over the past decade in the United States. Available literature indicates that sociodemographic factors may influence diagnostic patterns and/or prescription behaviour. Herein, the aim of this study is to determine whether the gender of the prescriber and/or patient influences BZD prescription.MethodsCross-sectional study using data from the Florida Medicaid Managed Medical Assistance Program from January 1, 2018 to December 31, 2018. Eligible recipients ages 18 to 64, inclusive, enrolled in the Florida Medicaid plan for at least 1 day, and were dually eligible. Recipients either had a serious mental illness (SMI), or non-SMI and anxiety.ResultsTotal 125 463 cases were identified (i.e., received BZD or non-BZD prescription). Main effect of patient and prescriber gender was significant F(1, 125 459) = 0.105, P = 0 .745, partial η2 < 0.001. Relative risk (RR) of male prescribers prescribing a BZD compared to female prescribers was 1.540, 95% confidence intervals (CI) [1.513, 1.567], whereas the RR of male patients being prescribed a BZD compared to female patients was 1.16, 95% CI [1.14, 1.18]. Main effects of patient and prescriber gender were statistically significant F(1, 125 459) = 188.232, P < 0.001, partial η2 = 0.001 and F(1, 125 459) = 349.704, P < 0.001, partial η2 = 0.013, respectively.ConclusionsMale prescribers are more likely to prescribe BZDs, and male patients are more likely to receive BZDs. Further studies are required to characterize factors that influence this gender-by-gender interaction.
Trends in suicide rates during the COVID-19 pandemic restrictions in a major German city
Authors: Radeloff Daniel , Papsdorf Rainer , Uhlig Kirsten , Vasilache Andreas , Putnam Karen , von Klitzing Kai 
Published: January 2021

AbstractAimsIt remains unclear whether the coronavirus disease 2019 (COVID-19) pandemic is having an impact on suicide rates (SR). Economic insecurity and mental disorders are risk factors for suicide, which may increase during the pandemic.MethodsData on suicide events in a major city in Germany, and the corresponding life years (LY) were provided by the local authorities. For the year 2020, periods without restrictions on freedom of movement and social contact were compared with periods of moderate and severe COVID-19 restrictions. To avoid distortions due to seasonal fluctuations and linear time trends, suicide risk during the COVID-19 pandemic was compared with data from 2010 to 2019 using an interrupted time series analysis.ResultsA total of 643 suicides were registered and 6 032 690 LY were spent between 2010 and 2020. Of these, 53 suicides and 450 429 LY accounted for the year 2020.In 2020, SR (suicides per 100 000 LY) were lower in periods with severe COVID-19 restrictions (SR = 7.2,χ2= 4.033,p= 0.045) compared with periods without restrictions (SR = 16.8). A comparison with previous years showed that this difference was caused by unusually high SR before the imposition of restrictions, while SR during the pandemic were within the trend corridor of previous years (expected suicides = 32.3, observed suicides = 35; IRR = 1.084,p= 0.682).ConclusionsSR during COVID-19 pandemic are in line with the trend in previous years. Careful monitoring of SR in the further course of the COVID-19 crisis is urgently needed. The findings have regional reference and should not be over-generalised.
Response of Palmer amaranth (Amaranthus palmeri S. Watson) and sugarbeet to desmedipham and phenmedipham
Authors: Beiermann Clint W. , Creech Cody F. , Knezevic Stevan Z. , Jhala Amit J. , Harveson Robert , Lawrence Nevin C. 
Published: January 2021

AbstractA prepackaged mixture of desmedipham + phenmedipham was previously labeled for control of Amaranthus spp. in sugarbeet. Currently, there are no effective POST herbicide options to control glyphosate-resistant Palmer amaranth in sugarbeet. Sugarbeet growers are interested in using desmedipham + phenmedipham to control escaped Palmer amaranth. In 2019, a greenhouse experiment was initiated near Scottsbluff, NE, to determine the selectivity of desmedipham and phenmedipham between Palmer amaranth and sugarbeet. Three populations of Palmer amaranth and four sugarbeet hybrids were evaluated. Herbicide treatments consisted of desmedipham and phenmedipham applied singly or as mixtures at an equivalent rate. Herbicides were applied when Palmer amaranth and sugarbeet were at the cotyledon stage, or two true-leaf sugarbeet stage and when Palmer amaranth was 7 cm tall. The selectivity indices for desmedipham, phenmedipham, and desmedipham + phenmedipham were 1.61, 2.47, and 3.05, respectively, at the cotyledon stage. At the two true-leaf application stage, the highest rates of desmedipham and phenmedipham were associated with low mortality rates in sugarbeet, resulting in a failed response of death. The highest rates of desmedipham + phenmedipham caused a death response of sugarbeet; the selectivity index was 2.15. Desmedipham treatments resulted in lower LD50 estimates for Palmer amaranth compared to phenmedipham, indicating that desmedipham can provide greater levels of control for Palmer amaranth. However, desmedipham also caused greater injury in sugarbeet, producing lower LD50 estimates compared to phenmedipham. Desmedipham + phenmedipham provided 90% or greater control of cotyledon-size Palmer amaranth at a labeled rate but also caused high levels of sugarbeet injury. Neither desmedipham, phenmedipham, nor desmedipham + phenmedipham was able to control 7-cm tall Palmer amaranth at previously labeled rates. Results indicate that desmedipham + phenmedipham can only control Palmer amaranth if applied at the cotyledon stage and a high level of sugarbeet injury is acceptable.
Quantifying glyphosate plus 2,4-D or dicamba removal from the surface of totally impermeable film using analytical and bioassay techniques
Authors: Hand Lavesta C. , Eason Kayla M. , Randell Taylor M. , Grey Timothy L. , Richburg John S. , Culpepper A. Stanley 
Published: January 2021

AbstractThe loss of methyl bromide led vegetable growers to rely more heavily on herbicides to control weeds. Although herbicides can be effective, limited options in vegetable production challenge growers. Identifying new, effective tools to be applied over plastic mulch before planting, for improved weed control with minimal crop injury, would be beneficial. The objective of these experiments was to evaluate the persistence of preplant applications of glyphosate (1,125 or 2,250 g ae ha−1) plus 2,4-D (1,065 or 2,130 g ae ha−1) or dicamba (560 g ae ha−1) over plastic mulch, using analytical techniques and subsequent yellow squash and watermelon response. Glyphosate and 2,4-D were not analytically detected at damaging concentrations on plastic mulch when at least 3.5 cm of rainfall was received after application and before planting. In addition, bioassay results showing less than 10% visual injury for either squash and watermelon, with no growth or yield suppression observed, supported analytical results. In contrast, dicamba concentrations on plastic mulch, regardless of rainfall amount or time between application and planting, remained at damaging levels. Squash yields were reduced by dicamba applied 1 to 30 d before planting, whereas watermelon was more resilient. 2,4-D plus glyphosate applied preplant over plastic mulch can provide an additional herbicide option for vegetable growers. More research is needed to understand the impact of residual activity of 2,4-D when transplants land directly in holes in plastic mulch at the time of application. The relationship of dicamba with plastic mulch is complex, because the herbicide cannot be easily removed by rainfall. Thus, dicamba should not be included in a weed management system in plasticulture vegetable production.
The Lifetimes of Plasma Structures at High Latitudes
Authors: Ivarsen Magnus F. , Jin Yaqi , Spicher Andres , Miloch Wojciech , Clausen Lasse B. N. 
Published: January 2021

AbstractWe present an investigation of polar cap plasma structure lifetimes. We analyze both simulated data from ionospheric models (International Reference Ionosphere model and Mass Spectrometer Incoherent Scatter model) and in situ data from the Swarm satellite mission (the 16 Hz Advanced Plasma Density dataset). We find that the theoretical prediction that E‐region conductance is a predictor of F‐region polar cap plasma structure lifetimes is indeed supported by both in situ‐based observations and by ionospheric models. In situ plasma structure lifetimes correlate well with the ratio of F‐ to E‐region conductance. We present explicit predictions of small scale (∼1 km) structure lifetimes, which range from less than 1 h during local summer to around 3 h during local winter. We highlight a large discrepancy between the observational and theoretical scale‐dependency of decay due to diffusion.
Pressure‐Driven Poiseuille Flow Inherited From Mesozoic Mantle Circulation Led to the Eocene Separation of Australia and Antarctica
Authors: Stotz I. L. , Tassara A. , Iaffaldano G. 
Published: January 2021

AbstractThe separation between Australia and Antarctica occurred during the final stages of the break‐up of Pangea. Reconstructions of the rifting of the Australian plate away from Antarctica show fast spreading rates since Mid‐Eocene (45 Ma). These reconstructions can be used to understand and quantify the forces driving the Australia/Antarctica separation, and to test hypotheses on mechanisms that may be of shallow (i.e., lithosphere) or deep (i.e., mantle) origin. Analytical calculations indicate that plate‐boundary forces are highly unlikely to be a plausible candidate to explain such a separation. Thus, we use a recently developed global coupled models of mantle and lithosphere dynamics, here we show that this event, whose kinematics are reproduced in our models within the bounds of the reconstruction uncertainties, owes to a significant degree to the pressure‐driven asthenospheric Poiseuille flow associated with the mantle buoyancy field inherited from viscous circulation history throughout the Mesozoic. On the contrary, in simulations when such a buoyancy field is replaced by another one resulting from a random distribution of mantle temperature–thus not representative of Earth’s mantle circulation history–the rapid northward motion of Australia does not occur. Similarly, suppressing contemporaneous plate‐boundary processes (i.e., subduction of the Pacific ridge at the Aleutians and healing of the India‐Australia ridge) from our models does not have a noticeable effect on the Australia‐Antarctica kinematics. Thus, a pressure‐driven Poiseuille mantle flow must be considered, at least in this example and possible elsewhere, as a main driver of plate tectonics.
High‐Resolution Surveys of Phytoplankton‐Derived Polyunsaturated Aldehydes at Frontal Zones Outside a Eutrophic Estuary
Authors: Wu Zhengchao , Li Qian P. , Dong Yuan , Xu Jie , Luo Lin 
Published: January 2021

AbstractIn this study, we report high‐resolution spatiotemporal distributions of particulate polyunsaturated aldehyde (pPUA) and dissolved polyunsaturated aldehyde (dPUA) across a frontal system outside the Pearl River Estuary of the northern South China Sea (NSCS) by synthesizing field data collected during the summers of 2015, 2016, and 2019. High levels of pPUA (up to 40 nM) in the surface waters were related to intense phytoplankton blooms at the frontal zone dominated by PUA‐producing diatoms. We found phytoplankton chlorophyll‐a negatively correlated with the heptadienal percentage but positively correlated with the octadienal percentage in pPUA at the surface frontal zone, consistent with a cross‐front shift of the dominant PUA‐producing diatoms from Skeletonema costatum to Thalassiosira minima. Also, pPUA was significantly correlated with chlorophyll‐a in the surface boundary but with turbidity in the bottom boundary of the front during the cross‐front transect, indicating a biological source of surface pPUA but a sedimentary source of bottom pPUA (likely from the resuspended PUA precursors). At the frontal zone, a fast decrease of dPUA with depths below the mixed layer could be a result of enhanced mixing by the intruded bottom seawater. In summary, we reveal the complex distributions of pPUA and dPUA in the frontal system outside a eutrophic estuary, including both its surface and the bottom boundary layers. We further discuss the ecological and biogeochemical implications of the unique PUA distributional patterns on the NSCS shelf‐sea.