bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial colonisation during regular daily use of a power-driven water flosser and risk for cross-contamination. Can it be prevented?
Authors: Bertl Kristina , Geissberger Chiarra , Zinndorf David , Johansson Pia Edlund , Al-Shammari Hatem , Eick Sigrun , Stavropoulos Andreas 
Published: September 2021

Abstract

Objective
To assess whether bacterial colonisation in a power-driven water flosser can be prevented.

Materials and methods
Twenty-four patients undergoing supportive periodontal treatment used 2 power-driven water flossers [Sonicare AirFloss (SAF), AirFloss Ultra (SAFU)] for 12 weeks each as follows: (a) with bottled water (BW); (b) with BW and cleaning the device extra-orally twice per week with chlorhexidine gluconate or (c) essential-oil-based (EO) mouth-rinse; (d) with EO only. Water-jet samples were taken after 6 and 12 weeks with the used nozzle and after exchanging to a brand-new nozzle. After 12 weeks, all devices underwent an intensive cleaning procedure. Samples were analysed by PCR-based method for cariogenic and periodontal pathogens and culture for staphylococci, aerobe gram-negative bacteria, and Candida sp.

Results
Contamination of SAF/SAFU with Streptococcus mutans was found in > 95% of the samples; periodontal pathogens and aerobe gram-negative bacteria were detected in 19–56% of the samples, while Staphylococcus aureus and Candida sp. were identified only in few samples. Contamination rate was basically unaffected by time-point, device, or way of use. Further, exchanging the nozzle did not prevent transmission of a contaminated water-jet, but the intensive cleaning reduced most of the pathogens significantly, except of S. mutans.

Conclusion
Neither a specific way of use nor exchanging the nozzle prevented bacterial colonisation and transmission of biofilm components via the water-jet of SAF/SAFU.

Clinical relevance
Bacterial colonisation in a power-driven water flosser seems impossible to prevent; to restrict the risk of cross-contamination within a household, one device per person should be recommended.
Hybrid operation technique for incisional hernia repair: a systematic review and meta-analysis of intra- and postoperative complications
Authors: Van den Dop L. Matthijs , De Smet Gijs H. J. , Kleinrensink Gert-Jan , Hueting Willem E. , Lange Johan F. 
Published: September 2021

AbstractBackgroundIncisional hernia (IH) occurs approximately in 15% of patients after midline surgery. Surgical treatment for IHs include a solely open or solely laparoscopic approach with mesh placement. Recently, hybrid (combined laparoscopic and open) approaches have been introduced. This systematic review evaluates perioperative complications of hybrid incisional hernia repair (HIHR).MethodsEMBASE, Medline via OvidSP, Web of Science, Cochrane and Google Scholar databases were searched. Studies providing data on intra- and postoperative complications in patients who underwent HIHR were included. Data on intra- and postoperative complications were extracted and meta-analyses were performed. Study quality was assessed with the Newcastle Ottowa Scale, ROBINS-I tool, and Cochrane risk of bias. PROSPERO registration: CRD42020175053.ResultsEleven studies (n = 1681 patients) were included. Five studies compared intra-operative complications between HIHR and laparoscopic incisional hernia repair (LIHR) with a pooled incidence of 1.8% in HIHR group and 2.8% in LIHR group (p = 0.13). Comparison of postoperative prevalence of surgical site occurrences (SSOs) (23% versus 26%,p = 0.02) and surgical site occurrences requiring interventions (SSOPIs) (1.5% versus 4.1%,p < 0.01) were in favour of the HIHR group. Overall postoperative complications seemed to occur less frequent in the HIHR group, though no hard statements could be made due to the vast heterogeneity in reporting between studies.ConclusionAlthough the majority of studies were retrospective and included a small number of patients, HIHR seemingly led to less SSOs and SSOPIs. This systematic review forms a strong invitation for more randomized controlled trials to confirm the benefits of this approach.
Stratigraphic and structural controls on groundwater salinity variations in the Poso Creek Oil Field, Kern County, California, USA
Authors: Stephens Michael J. , Shimabukuro David H. , Chang Will , Gillespie Janice M. , Levinson Zack 
Published: September 2021

AbstractGroundwater total dissolved solids (TDS) distribution was mapped with a three-dimensional (3D) model, and it was found that TDS variability is largely controlled by stratigraphy and geologic structure. General TDS patterns in the San Joaquin Valley of California (USA) are attributed to predominantly connate water composition and large-scale recharge from the adjacent Sierra Nevada. However, in smaller areas, stratigraphy and faulting play an important role in controlling TDS. Here, the relationship of stratigraphy and structure to TDS concentration was examined at Poso Creek Oil Field, Kern County, California. The TDS model was constructed using produced water TDS samples and borehole geophysics. The model was used to predict TDS concentration at discrete locations in 3D space and used a Gaussian process to interpolate TDS over a volume. In the overlying aquifer, TDS is typically <1,000 mg/L and increases with depth to ~1,200–3,500 mg/L in the hydrocarbon zone below the Macoma claystone—a regionally extensive, fine-grained unit—and reaches ~7,000 mg/L in isolated places. The Macoma claystone creates a vertical TDS gradient in the west where it is thickest, but control decreases to the east where it pinches out and allows freshwater recharge. Previously mapped normal faults were found to exhibit inconsistent control on TDS. In one case, high-density faulting appears to prevent recharge from flushing higher-TDS connate water. Elsewhere, the high-throw segments of a normal fault exhibit variable behavior, in places blocking lower-TDS recharge and in other cases allowing flushing. Importantly, faults apparently have differential control on oil and groundwater.
Clinical features of autosomal recessive polycystic kidney disease in the Japanese population and analysis of splicing in PKHD1 gene for determination of phenotypes
Authors: Ishiko Shinya , Morisada Naoya , Kondo Atsushi , Nagai Sadayuki , Aoto Yuya , Okada Eri , Rossanti Rini , Sakakibara Nana , Nagano China , Horinouchi Tomoko , Yamamura Tomohiko , Ninchoji Takeshi , Kaito Hiroshi , Hamada Riku , Shima Yuko , Nakanishi Koichi , Matsuo Masafumi , Iijima Kazumoto , Nozu Kandai 
Published: September 2021

Abstract
Background
Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene. The clinical spectrum is often more variable than previously considered. We aimed to analyze the clinical features of genetically diagnosed ARPKD in the Japanese population.

Methods
We conducted a genetic analysis of patients with clinically diagnosed or suspected ARPKD in Japan. Moreover, we performed a minigene assay to elucidate the mechanisms that could affect phenotypes.

Results
PKHD1 pathogenic variants were identified in 32 patients (0–46 years). Approximately one-third of the patients showed prenatal anomalies, and five patients died within one year after birth. Other manifestations were detected as follows: chronic kidney disease stages 1–2 in 15/26 (57.7%), Caroli disease in 9/32 (28.1%), hepatic fibrosis in 7/32 (21.9%), systemic hypertension in 13/27 (48.1%), and congenital hypothyroidism in 3 patients. There have been reported that truncating mutations in both alleles led to severe phenotypes with perinatal demise. However, one patient without a missense mutation survived the neonatal period. In the minigene assay, c.2713C > T (p.Gln905Ter) and c.6808 + 1G > A expressed a transcript that skipped exon 25 (123 bp) and exon 41 (126 bp), resulting in an in-frame mutation, which might have contributed to the milder phenotype. Missense mutations in cases of neonatal demise did not show splicing abnormalities.

Conclusion
Clinical manifestations ranged from cases of neonatal demise to those diagnosed in adulthood. The minigene assay results indicate the importance of functional analysis, and call into question the fundamental belief that at least one non-truncating mutation is necessary for perinatal survival.
Continuous assessment of landslides by measuring their basal temperature
Authors: Seguí Carolina , Veveakis Manolis 
Published: September 2021

AbstractIn this study, we suggest a temperature-based assessment and mitigation approach for deep-seated landslides that allows to forecast the behavior of the slide and assess its stability. The suggested approach is validated through combined field monitoring and experimental testing of the El Forn landslide (Andorra), whose shear band material is Silurian shales. Thermal and rate controlled triaxial tests have shown that this material is thermal- and rate-sensitive, and in combination with the field data, they validate the theoretical assumption that by measuring the basal temperature of an active landslide, we can quantify and reduce the uncertainty of the model’s parameters, and adequately monitor and forecast the response of the selected deep-seated landslide. The data and results of this letter show that the presented model can give threshold values that can be used as an early-warning assessment and mitigation tool.
Hypothesis-driven science in large-scale studies: the case of GWAS
Authors: Read James , Sharma Sumana 
Published: September 2021

AbstractIt is now well-appreciated by philosophers that contemporary large-scale ‘-omics’ studies in biology stand in non-trivial relationships to more orthodox hypothesis-driven approaches. These relationships have been clarified by Ratti (2015); however, there remains much more to be said regarding how an important field of genomics cited in that work—‘genome-wide association studies’ (GWAS)—fits into this framework. In the present article, we propose a revision to Ratti’s framework more suited to studies such as GWAS. In the process of doing so, we introduce to the philosophical literature novel exploratory experiments in (phospho)proteomics, and demonstrate how these experiments interplay with the above considerations.
Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
Authors: Ribeiro Fernando Fonseca França , Moreira Henrique Turin , de Barros-Filho Antônio Carlos Leite , Tanaka Denise M. , Fabricio Camila G. , Oliveira Luciano F. L. , Prado Cibele M. , Simões Marcus V. , Schmidt André , Maciel Benedito C. , Marin-Neto José A. , Romano Minna Moreira Dias 
Published: September 2021

AbstractSpeckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Echocardiography was performed before the infection (baseline), at 1 month (acute phase), 4, 6, and 8 months (chronic phase) using Vevo 2100 (Fujifilm Inc.) ultrasound system. Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter (LVESD), Left ventricular ejection fraction (LVEF), Global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were evaluated. Tricuspid annular plane systolic excursion (TAPSE) was used to assess right ventricular function. At 8 months, animals were euthanized and LV myocardial samples were analyzed for quantitation of inflammation and fibrosis. LVEF decreased over time in Chagas group and a difference from Control was detected at 6 months (p-value of groups#time interaction = 0.005). There was a pronounced decrease in GLS, GCS and TAPSE in Chagas group (p-value of groups#time interaction = 0.003 for GLS, < 0.001 for GCS and < 0.009 for TAPSE vs Control) since the first month. LVESD, LVEF and GLS were significantly correlated to the number of inflammatory cells (r = 0.41, p = 0.046; r = − 0.42, p = 0.042; r = 0.41, p = 0.047) but not to fibrosis. In the Syrian hamster model of CD STE parameters (GLS and GCS) showed an early decrease. Changes in LVEF, LVESD, and GLS were correlated to myocardial inflammation but not to fibrosis.
The Electronic Corpus of 17th- and 18th-century Polish Texts
Authors: Gruszczyński Włodzimierz , Adamiec Dorota , Bronikowska Renata , Kieraś Witold , Modrzejewski Emanuel , Wieczorek Aleksandra , Woliński Marcin 
Published: September 2021

AbstractThe paper describes the process of building the electronic corpus of 17th- and 18th-century Polish texts, a relatively large, balanced, structurally and morphologically annotated resource of the Middle Polish language, available for searching at https://www.korba.edu.pl. The corpus consists of samples extracted from over seven hundred texts written and published between 1601 and 1772, summing up to a total size of 13.5 million tokens which makes it one of the largest historical corpora for a Slavic language.
Unpacking future climate extremes and their sectoral implications in western Nepal
Authors: Chapagain Dipesh , Dhaubanjar Sanita , Bharati Luna 
Published: September 2021

AbstractExisting climate projections and impact assessments in Nepal only consider a limited number of generic climate indices such as means. Few studies have explored climate extremes and their sectoral implications. This study evaluates future scenarios of extreme climate indices from the list of the Expert Team on Sector-specific Climate Indices (ET-SCI) and their sectoral implications in the Karnali Basin in western Nepal. First, future projections of 26 climate indices relevant to six climate-sensitive sectors in Karnali are made for the near (2021–2045), mid (2046–2070), and far (2071–2095) future for low- and high-emission scenarios (RCP4.5 and RCP8.5, respectively) using bias-corrected ensembles of 19 regional climate models from the COordinated Regional Downscaling EXperiment for South Asia (CORDEX-SA). Second, a qualitative analysis based on expert interviews and a literature review on the impact of the projected climate extremes on the climate-sensitive sectors is undertaken. Both the temperature and precipitation patterns are projected to deviate significantly from the historical reference already from the near future with increased occurrences of extreme events. Winter in the highlands is expected to become warmer and dryer. The hot and wet tropical summer in the lowlands will become hotter with longer warm spells and fewer cold days. Low-intensity precipitation events will decline, but the magnitude and frequency of extreme precipitation events will increase. The compounding effects of the increase in extreme temperature and precipitation events will have largely negative implications for the six climate-sensitive sectors considered here.
Does the Dome Defeat the Material Theory of Induction?
Authors: Peden William 
Published: September 2021

AbstractAccording to John D. Norton's Material Theory of Induction, all inductive inferences are justified by local facts, rather than their formal features or some grand principles of nature's uniformity. Recently, Richard Dawid (Found Phys 45(9):1101–1109, 2015) has offered a challenge to this theory: in an adaptation of Norton's own celebrated "Dome" thought experiment, it seems that there are certain inductions that are intuitively reasonable, but which do not have any local facts that could serve to justify them in accordance with Norton's requirements. Dawid's suggestion is that “raw induction” might have a limited but important role for such inferences. I argue that the Material Theory can accommodate such inductions, because there are local facts concerning the combinatoric features of the induction’s target populations that can licence the inferences in an analogous way to existing examples of material induction. Since my arguments are largely independent of the details of the Dome, Norton's theory emerges as surprisingly robust against criticisms of excessive narrowness.
Assertion: The Constitutive Rule Account and the Engagement Condition Objection
Authors: Bräuer Felix 
Published: September 2021

AbstractMany philosophers, following Williamson (The Philosophical Review 105(4): 489–523, 1996), Williamson (Knowledge and its Limits, Oxford, Oxford University Press, 2000), subscribe to the constitutive rule account of assertion (CRAA). They hold that the activity of asserting is constituted by a single constitutive rule of assertion. However, in recent work, Maitra (in: Brown & Cappelen (ed). Assertion: new philosophical essays, Oxford, Oxford University Press, 2011), Johnson (Acta Analytica 33(1): 51–67, 2018), and Kelp and Simion (Synthese 197(1): 125–137, 2020a), Kelp and Simion (in: Goldberg (ed) The Oxford Handbook of Assertion, Oxford, Oxford University Press, 2020b) aim to show that, for all the most popular versions of the constitutive rule of assertion proposed in the literature, asserting is not an activity constituted by a single constitutive rule and that therefore CRAA is very likely false. To reach this conclusion, they all present a version of what can be dubbed the engagement condition objection. That is, they each propose a necessary condition on engaging in rule-constituted activities. Then they argue that, for all the most popular versions of the constitutive rule of assertion proposed in the literature, one can make assertions without satisfying this condition. In response, I present a counterexample that shows that the proposed engagement conditions lead to counterintuitive results, and I propose an alternative that better captures our intuitions. Then I argue that this alternative engagement condition is compatible with all the most popular versions of the constitutive rule of assertion.
A Virtue Reliabilist Error-Theory of Defeat
Authors: Hirvelä Jaakko 
Published: September 2021

AbstractKnowledge defeat occurs when a subject knows that p, gains a defeater for her belief, and thereby loses her knowledge without necessarily losing her belief. It’s far from obvious that externalists can accommodate putative cases of knowledge defeat since a belief that satisfies the externalist conditions for knowledge can satisfy those conditions even if the subject later gains a defeater for her belief. I’ll argue that virtue reliabilists can accommodate defeat intuitions via a new kind of error theory. I argue that in cases where the subject holds dogmatically onto her belief in the face of an apparent defeater, her belief never qualified as knowledge, since the belief was not gained via an exercise of her epistemic virtues. In cases where the subject suspends her judgment upon receiving the putative defeater her original belief might have qualified as knowledge, but crucially, in such cases knowledge is lost due to loss of belief, rather than due to the epistemic force of the defeater. Therefore, knowledge defeat isn’t a genuine phenomenon even though there are no cases where a subject knows what she originally believed after receiving the putative defeater.
Computer-Mediated Communication and Child/Adolescent Friendship Quality after Residential Relocation
Authors: Wendt Ruth , Langmeyer Alexandra N. 
Published: September 2021

AbstractThe experience of residential relocation can affect children and adolescents in various ways. It often affects their close social relationships, and this is especially true when these individuals are no longer in close proximity to their family members and friends. Although face-to-face communication may be limited after relocation, computer-mediated communication can assist in maintaining and developing existing relationships. It may even help individuals initiate new social relationships. In the present study, we investigated the role of communication behavior with friends for perceived friendship quality among children and adolescents who recently experienced residential relocation. Based on a representative survey study of families in Germany, we selected parents having moved with their child (8 to 14 years) to another village or town within the last 24 months. In total, 57 parents who had recently moved – majority of whom were mothers – allowed their child to participate in the phone interview. These participants were, on average, 11 years of age, and 58% of them were male. The children answered questions about their communication behavior and the friendships they had with their three current best friends. Using multilevel analysis, we found that children and adolescents who more often communicated face-to-face with their friends also more intensively used computer-mediated technologies to stay in touch. However, the findings further revealed that computer-mediated communication has the potential to remove limitations in existing friendships in the event of relocation. In the following discussion, implications are examined regarding the role of new communication technologies for families with enhanced mobility requirements.
Prosocial Behavior Is a Relative Strength in Siblings of Children with Physical Disabilities or Autism Spectrum Disorder
Authors: Orm Stian , Haukeland Yngvild , Vatne Torun , Silverman Wendy K. , Fjermestad Krister 
Published: September 2021

AbstractResearch on siblings of children with developmental and physical disabilities has emphasized negative influences on siblings’ mental health. Yet, such siblings may be more prosocial compared with siblings of children without disabilities, due to care responsibilities and their experiences with their brother’s or sister’s disability. We compared prosocial behavior between siblings of children with autism spectrum disorder (ASD; n = 47), physical disabilities (n = 42), and siblings of children without disabilities (n = 44) using a multi-informant approach (i.e., child-, mother-, and father-report). Prosocial behavior was measured with the Strengths and Difficulties Questionnaire. Drawing on the theoretical and empirical sibling literature, we also examined whether siblings’ internalizing and externalizing difficulties, adjustment to the sibling situation, and communication with parents correlated with siblings’ prosocial behavior. Child-reported internalizing difficulties and mother–child communication significantly correlated with mother-reported prosocial behavior. Child-reported internalizing and externalizing difficulties significantly correlated with father-reported prosocial behavior. No significant correlates with child-reported prosocial behavior was identified. When adjusting for siblings’ internalizing and externalizing difficulties and mother–child communication, siblings of children with physical disabilities scored significantly higher than siblings of children without disabilities on mother- and father-reported prosocial behavior. Siblings of children with ASD scored significantly higher on mother-reported prosocial behavior. We conclude that prosocial behavior may be a relative strength in siblings of children with developmental and physical disabilities, and that siblings’ prosocial behavior may be influenced by type of disability, mental health, and family communication. Interventions targeting siblings’ mental health and family communication may be helpful in promoting siblings’ prosocial behavior.