bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explaining coincidences
Authors: De Rizzo Julio 
Published: November 2021

AbstractA traditional account of coincidences has it that two facts are coincidental whenever they are not related as cause and effect and do not have a common cause. A recent contribution by Lando (Noûs 51(1): 132–151, 2017) showed that this account is mistaken. In this paper, I argue against two alternative accounts of coincidences, one suggested by Lando, and another by Bhogal (Philos Phenomenol Res 100(3): 677–694, 2020), and defend a third one in their place. In short, I propose that howexplanatory linksrelate to non-coincidental facts in explanation is what drives a wedge between coincidences and non-coincidences. This proposal is not susceptible to the worries I raise, and is more general, since it is not restricted to coincidences and non-coincidences involving physical facts.
Gating by Memory: a Theory of Learning in the Cerebellum
Authors: Gilbert Mike 
Published: November 2021

AbstractThis paper presents a model of learning by the cerebellar circuit. In the traditional and dominant learning model, training teaches finely graded parallel fibre synaptic weights which modify transmission to Purkinje cells and to interneurons that inhibit Purkinje cells. Following training, input in a learned pattern drives a training-modified response. The function is that the naive response to input rates is displaced by a learned one, trained under external supervision. In the proposed model, there is no weight-controlled graduated balance of excitation and inhibition of Purkinje cells. Instead, the balance has two functional states—a switch—at synaptic, whole cell and microzone level. The paper is in two parts. The first is a detailed physiological argument for the synaptic learning function. The second uses the function in a computational simulation of pattern memory. Against expectation, this generates a predictable outcome from input chaos (real-world variables). Training always forces synaptic weights away from the middle and towards the limits of the range, causing them to polarise, so that transmission is either robust or blocked. All conditions teach the same outcome, such that all learned patterns receive the same, rather than a bespoke, effect on transmission. In this model, the function of learning is gating—that is, to select patterns that trigger output merely, and not to modify output. The outcome is memory-operated gate activation which operates a two-state balance of weight-controlled transmission. Group activity of parallel fibres also simultaneously contains a second code contained in collective rates, which varies independently of the pattern code. A two-state response to the pattern code allows faithful, and graduated, control of Purkinje cell firing by the rate code, at gated times.
Pressure infiltration of molten aluminum for densification of environmental barrier coatings
Authors: Dong Lin , Liu Mei-Jun , Zhang Xiao-Feng , Zhuo Xue-Shi , Fan Jia-Feng , Yang Guan-Jun , Zhou Ke-Song 
Published: November 2021

AbstractEnvironmental barrier coatings (EBCs) effectively protect the ceramic matrix composites (CMCs) from harsh engine environments, especially steam and molten salts. However, open pores inevitably formed during the deposition process provide the transport channels for oxidants and corrosives, and lead to premature failure of EBCs. This research work proposed a method of pressure infiltration densification which blocked these open pores in the coatings. These results showed that it was difficult for aluminum to infiltrate spontaneously, but with the increase of external gas pressure and internal vacuum simultaneously, the molten aluminum obviously moved forward, and finally stopped infiltrating at a depth of a specific geometry. Based on the wrinkled zigzag pore model, a mathematical relationship between the critical pressure with the infiltration depth and the pore intrinsic geometry was established. The infiltration results confirmed this relationship, indicating that for a given coating, a dense thick film can be obtained by adjusting the internal and external gas pressures to drive a melt infiltration.
Which states parties should be held responsible for the implementation of positive obligations under the ECHR in sports-related disputes?
Authors: Shinohara Tsubasa 
Published: November 2021

AbstractIn sports society, awareness of human rights protection has gradually developed and sports governing bodies, such as the International Olympic Committee (IOC) and the Fédération Internationale de la Football Association (FIFA), have striven to commit the implementation of human rights guaranteed by internationally recognised human right treaties in the international community. However, human rights law cannot directly impose any legal obligations on sports governing bodies because they are non-state actors established by domestic private law. In this situation, how can international human rights law apply to the private relationship between non-state actors? According to the European Convention on Human Rights (ECHR), state parties must implement positive obligations to protect individuals against any violations caused by non-state actors within the jurisdiction. To implement the positive obligations under the ECHR, it is necessary to identify which state parties should be held responsible for the implementation in sports-related disputes because, in Mutu and Pechstein v. Switzerland, athletes claimed a violation of the ECHR against Switzerland on the ground that the Court of Arbitration for Sport (CAS) is located in Lausanne, Switzerland. However, it should be considered that Switzerland is not be liable for all violations of the ECHR’s rights caused by another state party. In light of this, the purpose of this article is to identify a hypothetical standard for determining which state parties should be held responsible for implementing the positive obligations under the ECHR.
Polyethylene glycol derived carbon quantum dots nanofluids: An excellent lubricant for diamond-like carbon film/bearing steel contact
Authors: Wang Fu , Shang Lunlin , Zhang Guangan , Wang Zhaofeng 
Published: November 2021

AbstractPolyethylene glycol derived carbon quantum dots nanofluids were synthesized via a slow thermal oxidation process. The size of carbon quantum dots was ca. 2 nm and had a decreasing trend with the increase of oxidation time. When used as lubricant in a diamond-like carbon film/bearing steel interface, the nanofluids achieved an ultra-low friction coefficient (μ ≈ 0.02), much lower than that of original polyethylene glycol (μ = 0.12). The worn surface analyses revealed that the nanofluids could effectively inhibit the tribo-oxidation of steel counterpart that occurred under original polyethylene glycol lubrication, and hence reduced the abrasion component of friction. Especially, the poly-hydroxyl carbon dots and oxidized polyethylene glycol species in nanofluids induced a hydroxyl-rich sliding interface via their tribochemical reactions with friction surfaces, which promoted the adsorption of polyethylene glycol molecules on sliding surfaces. Along with the mild corrosion wear of steel counterface, this shifted the boundary lubrication to a mixed/film lubrication regime, thereby achieving an ultra-low friction coefficient. The above results suggest that the polyethylene glycol derived carbon quantum dots nanofluids should be a quite excellent candidate lubricant for solid-liquid synergy lubrication based on diamond-like carbon films.
Potentials of the Three Spaces Theory for Understandings of Cartography, Virtual Realities, and Augmented Spaces
Authors: Kühne Olaf 
Published: November 2021

AbstractFor about three decades, cartography has been (critically) studied from a theoretical perspective. This perspective has contributed to the recognition of the social preconditions and effects of cartographic representations, but little to their further development. From the theory of three worlds, a theory of three spaces or its special case of landscapes is derived, whose modes of construction are presented as well as the derivations from the different modes. The categories of material, virtual and their combination of augmented spaces as well as the media (such as painting, texts or models) of the construction of space/landscape are added. The formulas derived from this illustrate the different aspects and relations of the constructions of space on the different levels and against the background of the different categories. Thus developed, the theory of three spaces or landscapes provides a framework for neopragmatic exploration, here, of maps, virtual and augmented spaces.
Bacterial coinfections with coronavirus disease 2019 (COVID-19)
Authors: Huang Glen , Furukawa Daisuke , Yang Bryant D. , Kim Brian J. , Jeng Arthur C. 
Published: November 2021

Abstract

Background:
The pandemic caused by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) has dramatically increased cheshospitalizations, and it is often difficult to determine whether there is a bacterial or fungal coinfection at time of presentation. In this study, we sought to determine the rates of coinfection and utilization of antibiotics in SARS-CoV-2 disease.

Methods:
Retrospective chart review of patients hospitalized with COVID-19 pneumonia from April 13, 2020, to July 14, 2020.

Results:
In total, 277 patients were hospitalized for COVID-19 pneumonia during this period. Patients that received antibiotics within 48 hours of presentation were more likely to be febrile (59.3% vs 41.2%; P = .01) and to have leukocytosis (23.9% vs 5.9%; P < .01) and were less likely to have a procalcitonin level <0.25 ng/mL (58.8% vs 74.5%; P = .04). In total, 45 patients had positive blood cultures collected during hospitalization, 16 of which were clinically significant. Of the clinically significant blood cultures, 5 were collected <48 hours of admission. Moreover, 18 sputum cultures were clinically significant, 2 of which were collected within 48 hours of admission.

Conclusion:
Bacterial and fungal coinfections in COVID-19 appear to be rare on presentation; thus, this factor may be a good target for enhanced antibiotic stewardship.
Effects of antibiotic suppression on three healthcare systems’ National Healthcare Safety Network Antibiotic Resistance Option data
Authors: Evans Christopher D. , Estes Matthew D. , Ouedraogo Youssoufou , Muleta Daniel , Kainer Marion A. , Talley Pamela P. 
Published: November 2021

Abstract

Objective:
The National Healthcare Safety Network (NHSN) Antibiotic Resistance (AR) Option is a valuable tool that can be used by acute-care hospitals to track and report antibiotic resistance rate data. Selective and cascading reporting results in suppressed antibiotic susceptibility results and has the potential to adversely affect what data are submitted into the NHSN AR Option. We describe the effects of antibiotic suppression on NHSN AR Option data.

Methods:
NHSN AR Option data were collected from 14 hospitals reporting into an existing NHSN user group from January 1, 2017, to December 31, 2018, and linked to commercial automated antimicrobial susceptibility testing instruments (cASTI) that were submitted as part of unrelated Tennessee Emerging Infections Program surveillance projects. A susceptibility result was defined as suppressed if the result was not found in the NHSN AR Option data but was reported in the cASTI data. Susceptibility results found in both data sets were described as released. Proportions of suppressed and released results were compared using the Pearson χ2 and Fisher exact tests.

Results:
In total, 852 matched isolates with 3,859 unique susceptibilities were available for analysis. At least 1 suppressed antibiotic susceptibility result was available for 726 (85.2%) of the isolates. Of the 3,859 susceptibility results, 1,936 (50.2%) suppressed antibiotic susceptibility results were not reported into the NHSN AR option when compared to the cASTI data.

Conclusion:
The effect of antibiotic suppression described in this article has significant implications for the ability of the NHSN AR Option to accurately reflect antibiotic resistance rates.
MODEL THEORY OF DERIVATIONS OF THE FROBENIUS MAP REVISITED
Authors: GOGOLOK JAKUB 
Published: November 2021

AbstractWe prove some results about the model theory of fields with a derivation of the Frobenius map, especially that the model companion of this theory is axiomatizable by axioms used by Wood in the case of the theory
$\operatorname {DCF}_p$
and that it eliminates quantifiers after adding the inverse of the Frobenius map to the language. This strengthens the results from [4]. As a by-product, we get a new geometric axiomatization of this model companion. Along the way we also prove a quantifier elimination result, which holds in a much more general context and we suggest a way of giving “one-dimensional” axiomatizations for model companions of some theories of fields with operators.
Psychophysiology, cognition, and political differences
Authors: Mansell Jordan , Harell Allison , Gidengil Elisabeth , Stewart Patrick A. 
Published: November 2021

AbstractWe introduce thePolitics and the Life Sciencesspecial issue on Psychophysiology, Cognition, and Political Differences. This issue represents the second special issue funded by the Association for Politics and the Life Sciences that adheres to the Open Science Framework for registered reports (RR). Here pre-analysis plans (PAPs) are peer-reviewed and given in-principle acceptance (IPA) prior to data being collected and/or analyzed, and are published contingent upon the preregistration of the study being followed as proposed. Bound by a common theme of the importance of incorporating psychophysiological perspectives into the study of politics, broadly defined, the articles in this special issue feature a unique set of research questions and methodologies. In the following, we summarize the findings, discuss the innovations produced by this research, and highlight the importance of open science for the future of political science research.
State reach and development in Africa since the 1960s: new data and analysis
Authors: Müller-Crepon Carl 
Published: November 2021

AbstractProminent arguments hold that African states’ geography limits state capacity, impedes public service provision, and slows economic development. To test this argument, I collect comprehensive panel data on a proxy of local state capacity, travel times to national and regional capitals. These are computed on a yearly 5 × 5 km grid using time-varying data on roads and administrative units (1966–2016). I use these data to estimate the effect of changes in travel times to capitals on local education provision, infant mortality rates, and nightlight emissions. Within the same location, decreases in travel times to its capitals are robustly associated with improved development outcomes. The article advances the measurement of state capacity and contributes to understanding its effects on human welfare.
Representative Democracy and Colonial Inspirations: The Case of John Stuart Mill
Authors: LEDERMAN SHMUEL 
Published: November 2021

Focusing on John Stuart Mill, a particularly illuminating contributor to modern democratic theory, this article examines the connections between modern democracy and the European colonial experience. It argues that Mill drew on the exclusionary logic and discourse available through the colonial experience to present significant portions of the English working classes as domestic barbarians, whose potential rise to power posed a danger to civilization itself: a line of argument that helped him legitimate representative government as a democratic, rather than an antidemocratic form of government, as it had been traditionally perceived. The article contributes to our understanding of the development of modern democratic theory and practice by drawing attention to the ways the colonial experience shaped core Western institutions and ways of thinking, and it makes the case that this experience remains an essential, if often unacknowledged, part of our collective “self.”
Necrotising otitis externa: the increasing financial burden on the National Health Service
Authors: Godbehere J , Hutson K H , Watson G J 
Published: November 2021

AbstractObjectiveNecrotising otitis externa is increasingly being seen and treated within the UK. The aim of this study was to explore the potential cost of a cohort of patients with necrotising otitis externa presenting to a single tertiary NHS trust.MethodThis was a retrospective study with data from 14 patients with confirmed necrotising otitis externa who were treated, monitored, discharged or who died between October 2016 and November 2018. Direct costs using the tariffs from the 2018 to 2019 financial year included in-patient stay, imaging, peripheral inserted central catheter line cost, ENT and out-patient parenteral antibiotic therapy visits and antimicrobial duration.ResultsThe mean cost of treatment per patient was £17 615 (range, £9407 to £38 230) with an extreme outlier costing more than £122 000.ConclusionAwareness and education at a primary care level and research into robust imaging to aid termination of treatment may lower costs in the future by catching pathology early and reducing treatment duration.
New Estimates on the Basalt Volume of the Tarim (Not So Large) Igneous Province, NW China
Authors: Blacker Kieran J. , Wang Zhenchao , Zhang Zhaochong , Reichow Marc K. 
Published: November 2021

AbstractThe early Permian basalts of the Tarim Basin of NW China are geographically widespread, covering over 200,000 km2 and are in places up to 1‐km thick and hence frequently referred to represent a Large Igneous Province (LIP). Available volume estimates are based on average lava thickness multiplied by area, using these values results in volumes exceeding 100,000 km3, and is commonly cited as being evidence of LIP status. Using a database of 58 boreholes, field sections, and seismic data we calculate a range of basalt isopach maps, and use these to estimate new, more refined overall eruption volumes. These volumes are significantly smaller than previously reported estimates. We demonstrate that the thickness distribution of erupted basalts is nonuniform and strongly skewed, indicating that volume estimates using an arithmetically averaged thickness of input data will result in overestimation of total volumes. We find that even with the addition of an estimated nonerupted volume component, representing cumulates and intrusions, that the total volume of the Tarim volcanics is significantly below the minimum threshold of a LIP. Using a simple Monte Carlo model we demonstrate that even while accounting for uncertainty and error in the input data, the probability of the total volume exceeding 100,000 km3 is very low. The new volume estimates imply a revision of the climate and environmental impact of the Tarim volcanism. We therefore suggest that the term Tarim Igneous Province should be used instead of Tarim Large Igneous Province.
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis
Authors: Li Qingxian , Wen Yinxian , Wang Linlong , Chen Biao , Chen Jun , Wang Hui , Chen Liaobin 
Published: November 2021

AbstractOsteoarthritis (OA) is significantly associated with diabetes, but how hyperglycemia induces or aggravates OA has not been shown. The synovium plays a critical role in cartilage metabolism and substance exchange. Herein, we intended to investigate whether and how hyperglycemia affects the occurrence and progression of OA by influencing the synovium. In patients with knee OA and diabetes (DM OA), we found a more severe inflammatory response, higher endoplasmic reticulum stress (ERS) levels, and more advanced glycosylation end products (AGEs) accumulation in the synovium than in patients without diabetes. Subsequently, we found similar results in the DM OA group in a rat model. In the in vitro cocultivation system, high glucose-stimulated AGEs accumulation, ERS, and inflammation in rat fibroblast-like synoviocytes (FLSs), which resulted in chondrocyte degeneration due to inflammatory factors from FLSs. Furthermore, in the synovium of the DM OA group and FLSs treated with high glucose, the expression of glucose transporter 1 (GLUT1) and its regulatory factor hypoxia-inducible factor (HIF)-1α was increased significantly. Inhibitors of HIF-1α, GLUT1 or AGEs receptors attenuated the effect of high glucose on chondrocyte degradation in the FLS-chondrocyte coculture system. In summary, we demonstrated that hyperglycemia caused AGEs accumulation in FLSs via the HIF-1α-GLUT1 pathway, which increases the release of inflammatory factors from FLSs, subsequently inducing chondrocyte degradation and promoting OA progression.
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein
Authors: Li Hongyue , Zhang Yuhang , Li Dong , Deng Yong-Qiang , Xu Hongde , Zhao Chaoyue , Liu Jiandong , Wen Dan , Zhao Jianguo , Li Yongchun , Wu Yong , Liu Shujun , Liu Jiankai , Hao Junfeng , Yuan Fei , Duo Shuguang , Qin Cheng-Feng , Zheng Aihua 
Published: November 2021

AbstractSARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-SARS-CoV-2 and rVSV-SARS-CoV. Using wild-type and human ACE2 (hACE2) knock-in mouse models, we found a single dose of rVSV-SARS-CoV could elicit strong humoral immune response via both intranasal (i.n.) and intramuscular (i.m.) routes. Despite the high genetic similarity between SARS-CoV-2 and SARS-CoV, no obvious cross-neutralizing activity was observed in the immunized mice sera. In macaques, neutralizing antibody (NAb) titers induced by one i.n. dose of rVSV-SARS-CoV-2 were eight-fold higher than those by a single i.m. dose. Thus, our data indicates that rVSV-SARS-CoV-2 might be suitable for i.n. administration instead of the traditional i.m. immunization in human. Because rVSV-SARS-CoV elicited significantly stronger NAb responses than rVSV-SARS-CoV-2 in a route-independent manner, we generated a chimeric antigen by replacing the receptor binding domain (RBD) of SARS-CoV S with that from the SARS-CoV-2. rVSV expressing the chimera (rVSV-SARS-CoV/2-RBD) induced significantly increased NAbs against SARS-CoV-2 in mice and macaques than rVSV-SARS-CoV-2, with a safe Th1-biased response. Serum immunized with rVSV-SARS-CoV/2-RBD showed no cross-reactivity with SARS-CoV. hACE2 mice receiving a single i.m. dose of either rVSV-SARS-CoV-2 or rVSV-SARS-CoV/2-RBD were fully protected against SARS-CoV-2 challenge without obvious lesions in the lungs. Our results suggest that transplantation of SARS-CoV-2 RBD into the S protein of SARS-CoV might be a promising antigen design for COVID-19 vaccines.