bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphism of mixed cryoglobulinemia manifestations in hepatitis C virus chronic infection
Authors: Lukashyk S. P. , Karpov I. A. , Krasko O. V. 
Published: May 2021

Objective: to analyze the characteristics of hepatitis C virus chronic infection with concurrent cryogobulinemia, to assess the prevalence of extrahepatic diseases in the population of Belarusian patients under study.Material and methods. An open, non-randomized observational study with the inclusion of patients with hepatitis C virus (HCV) chronic infection and cryoglobulinemia (CG) was conducted.Results. The study has determined the core characteristics of HCV infection in CG patients, incidence rates and a wide array of extrahepatic diseases (EHDs), as well as HCV infection distinctive features compared to those without extrahepatic diseases.Conclusion. The revealed variety of common EHDs in HCV infection indicates that many organs and systems are involved in the pathological process and this variety should be taken into account when considering prognosis and treatment tactics.
Predictors of adverse COVID-19 outcomes in patients with oncohematological diseases
Authors: Shapetska M. M. , Iskrov I. A. , Lendina I. Yu. , Stoma I. O. 
Published: May 2021

Material and methods. We performed a prospective cohort study including 66 patients with oncohematological pathology and confirmed COVID-19 infection who underwent treatment at the SI “Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology” from March to September 2020.Results. The overwhelming majority of patients with hematological pathology and COVID-19 infection were diagnosed with multiple myeloma (MM) — 25 (37.8 %). The highest mortality rate was recorded in patients with multiple myeloma and acute leukemia (21 % and 12 %, respectively). Stage 4–5 chronic kidney disease (p<0.05, Fisher’s exact test; 0.01) is a statistically significant factor of adverse outcomes in patients with oncohematological diseases. The presence of coronary artery disease, diabetes mellitus or other pathology did not affect the outcome. We found no effect of previous polychemotherapy performed within the time of less than a month (HR 1.15; 95 % CI 0.66–2.0) and less than 3 months (HR 0.94 %; 95% CI 0.53–1.65) on the risk of the fatal outcome of the infection in patients with neoplastic diseases of hematopoietic tissue. Age over 60 (HR 1.8; 95 % CI 1.01-3.28) and the stage of progression according to the underlying disease (HR 2.8; 95 % CI 1.9–4.0) were statistically significant factors of the fatal outcome in patients with oncohematological diseases.Conclusion. The presented study has determined the predictors of the fatal outcome in COVID-19 patients with oncohematological diseases: age over 60 and the stage of progression of the underlying disease. At the same time, the highest mortality rate in COVID-19 was recorded in patients with multiple myeloma and acute leukemia (21 % and 12 %, respectively). Among all the analyzed comorbidity factors, stage 4–5 chronic kidney disease had a statistical significance for adverse outcomes.
Correlation between the level of bacterial load and clinical characteristics of the course of the disease in patients with neuroischaemic diabetic foot
Authors: Silvistrovich V. I. , Lyzikov A. A. , Yarets Yu. I. 
Published: May 2021

Objective:to analyze the clinical characteristics of the course of the disease in patients with neuroischaemic diabetic foot depending on the presence of bacterial monocultures and associations in wounds.Material and methods.We have performed a comparative analysis of the parameters of the clinical course of the disease and the condition of patients’ wounds (n = 76) depending on the presence of monocultures (group 1, n = 32) and microbial associations (n = 42). The list of the compared parameters in the groups included the duration of diabetes, number of hospitalizations per year, achievement of target HbA1c levels (<7.5 %), condition of granulation tissue of wounds.Results.With increased duration of the course of diabetes (from 5 to 15 years), higher number of hospitalizations per year, deteriorated carbohydrate metabolism (HbA1c> 7.5%) in combination with clinical signs of the initial stages of wound infection, the frequency rate of the detection of mixed bacterial cultures increased.Conclusion.The work has found differences in the duration of the course of diabetes, the number of hospitalizations per year, local status of wounds in the patients, as well as the frequency of achieving the target levels of HbA1с <7.5 %, depending on the severity of microbial load.
Hyperplastic processes in the endometrium of postmenopausal women
Authors: Lyzikova Yu. A. , Lyzikov A. N. 
Published: May 2021

Objective: to specify indications for endometrial biopsy in postmenopausal women with endometrial pathology revealed by ultrasound, to study the structure of comorbidity, the parity of pregnancies and childbirth in patients with endometrial hyperplasia.Material and methods. We performed an observational retrospective case-control study. The study included 60 postmenopausal patients with endometrial pathology revealed by ultrasound referred for further endometrial biopsy. After the results of the histological examination of the endometrium had been obtained, 30 patients who had detected endometrial pathology were included in the study group, 30 patients with histologically normal endometrium were included in the comparison group.Results. In comparing clinical and anamnestic data, no statistically significant differences have been found between the groups. The comparison of the indices of the ultrasound study of the uterus has revealed a statistically significant M-echo value in patients with confirmed endometrial pathology — 10.00 (8.00; 13.00) mm, in the comparison group — 7.80 (6.00; 9.75) mm. If an M-echo value is > 7 mm with a sensitivity of 76.67 % and a specificity of 46.65%, endometrial pathology is likely to develop. The area under the curve (AUC) was 0.706 (95 % CI 0.574 — 0.816; p < 0.001).Conclusion. The obtained data determine an M-echo value more than 7 mm detected by ultrasound as an indication for endometrial biopsy in postmenopausal patients. If an M-echo value is from 5 to 7 mm and clinical manifestations are absent, dynamic observation with ultrasound control can be performed. No specific risk factors for the disease have been found in the postmenopausal patients with endometrial hyperplasia, which necessitates the search for the genetic markers of estrogen metabolic disorders.
Evaluation of the state of the pro-oxidant/antioxidant system in children with hereditary spherocytosis
Authors: Mitsura E. F. , Novikova I. A. , Petrenko T. S. , Makeeva K. S. , Volkova L. I. 
Published: May 2021

Objective: to assess the state of the pro-oxidant/antioxidant system in children with hereditary spherocytosis (HS) depending on its severity.Material and methods. The study involved 44 HS patients at the age from 1 to 17 who were divided into 2 groups depending on the disease severity: mild course (n = 24) and moderate or severe course (n = 20). The control group included 23 practically healthy children who were comparable with the main group by gender and age. The state of the pro-oxidant/antioxidant balance of blood plasma was assessed by the method of luminol-dependent chemiluminescence (LDCL) with the determination of the maximum luminescence intensity (Imax, %) and the light sum of chemiluminescence (S, %). The activity of superoxide dismutase (SOD) and catalase was determined in the erythrocytes of the examined children.Results. On average, the parameters of the pro-oxidant/antioxidant status in the HS patients significantly differed from those of the control group (p <0.05), which corresponded to moderately pronounced oxidative stress. The activity of SOD and catalase in the erythrocytes of the patients was higher as compared with that of the control group (p = 0.0001 and p <0.0001, respectively). The comparison of the severity of oxidative stress depending on HS severity has determined that the degree of stress was more pronounced in patients with moderate or severe course of the disease (p <0.05).Conclusion. HS patients develop oxidative stress (decreased activity of the antioxidant system associated with increased accumulation of prooxidant substances), the degree of which is higher in patients with a severe course of the disease. This allows of considering plasma LDCL indicators as an additional marker for the assessment of the severity of the disease and of justifying the necessity to include antioxidants in the HS treatment regimen.
ESTRATÉGIAS DE REABILITAÇÃO EM AMBIENTE CARCERÁRIO: UMA DISCUSSÃO SOBRE SEGURANÇA PÚBLICA
Authors: Flores Higor Serra , Pires Diego Canabarro , Mateus Crauss  , Gomes Vinicius Machado , Oliveira Alexandre Souza , Moro Filipe dos Santos 
Published: May 2021

É comum diferentes veículos de mídia noticiarem diariamente casos de violência, que refletem índices de criminalidade cada vez mais altos no país, escancarando graves problemas de segurança pública e também transmitindo uma sensação de insegurança na população. Deste modo, se tornam também mais recorrentes as discussões de como criar estratégias para a diminuição destes preocupantes fatores; existem discursos variados nesse sentido, sendo que muitos colocam a maior repressão como uma alternativa, e outros enfatizam que as mudanças precisam ser mais profundas, reduzindo os abismos sociais e as desigualdades, como uma forma de pensar a segurança pública a médio e longo prazo. Na conjuntura destas estratégias mais amplas, não se pode deixar de lado a discussão acerca do sistema prisional brasileiro, que se mostra desestruturada e em desconformidade com preceitos constitucionais. Esse debate é importante, na medida em que a reabilitação de detentos, é uma ação relevante na busca da redução de índices de criminalidade. A partir disso, o estudo tem como objetivo analisar a importância da reestruturação do sisteprisional brasileiro, como objetivos específicos: analisar o atual panorama do sistema carcerário brasileiro, entender a função social e punitiva das prisões, analisar as consequências positivas dessa ideia de reformulação. O estudo se justifica a partir da ideia de que o sistema prisional brasileiro se encontra completamente desestruturado, não
cumprindo suas funções em conformidade com preceitos centrais da Constituição, como da dignidade e dos direitos humanos, além do Estado não garantir estratégias eficazes em relação a reabilitação dos detentos, visando mitigar os índices de reincidência criminal. Para alcançar os objetivos propostos, a pesquisa é fundamentada por meio de uma revisão de literatura, com caráter qualitativo, em pesquisas relacionadas a segurança pública, de entendimento das funções do sistema prisional, e de possíveis estratégias para resolver os diversos problemas observados nesse ambiente.
SEGURANÇA PÚBLICA BRASILEIRA NO PARADIGMA DO SISTEMA DE INFORMAÇÃO
Authors: Flores Higor Serra , Pires Diego Canabarro , Crauss Mateus , Gomes Vinicius Machado , Oliveira Alexandre Souza , Moro Filipe dos Santos 
Published: May 2021

Problemas de segurança pública tem alterado o modo de vida dos brasileiros. Atualmente, estes passaram a ser tratados e discutidos em todas as camadas da sociedade brasileira. A insegurança e o medo vivenciados pelos cidadãos é uma realidade traduzida em números crescentes de violência. Diante dessa realidade, medidas tomadas e apoiada pela opinião pública foi, de utilizar o direito legítimo do uso da força pelo Estado. A Constituição Federal de 1988, no seu Art. 144, externa que a segurança pública, é dever do Estado, direito e responsabilidade de todos e por isso não devem ser desvinculados da sua natureza sócio jurídica. Além do mais, os indivíduos, taxados como marginais, utilizam-se de novas tecnologias e estratégias nas ações criminosas. Sendo assim, os profissionais da área da segurança pública, devem ter o conhecimento prático e compreender o cenário atual da sociedade brasileira. O objetivo desta pesquisa é analisar a segurança pública brasileira no paradigma do sistema de informação. A problemática que esta matéria nos apresenta é de compreender que benefícios foram alcançados pela segurança pública com a utilização
do sistema de informação. A análise do tema, é de suma importância, uma vez que as questões de segurança pública têm influenciado o modo de vida dos brasileiros. O método hipotético-dedutivo, neste contexto, oferece os meios de construir, metodologicamente, a análise do tema desta pesquisa, de maneira a traçar o levantamento das variáveis por meio da formulação inicial de um problema, resultado de eventuais contradições e a formação de uma conjectura para responder ao problema inicialmente posto.
Reflexões sobre o filme Limite (1931), de Mário Peixoto, durante a pandemia
Authors: Alves Italo Bruno 
Published: May 2021

Este artigo revisita uma obra-prima do cinema brasileiro, o filme Limite, de Mário Peixoto. Agora, durante a pandemia, colocado para conversar com categorias espaciais gregas, Limite demonstra um novo potencial como ferramenta para abordar nossa atualidade espacial, de confinamento e globalização. Das tradições até as novas tecnologias de abordagem do espaço. Assim, o artigo convida os leitores a uma viagem rumo a um espaço que, desmembrado, pode aprimorar o senso de infinito.
Chuang Tzu e o pensamento da plenitude
Authors: Lira Costa André Vinicius 
Published: May 2021

Neste trabalho, será interpretado o pensamento de Chuang Tzu[1] com ênfase nas questões da felicidade e da liberdade, em dois de seus textos: “A grande sabedoria” e “Vida ativa”. A obra de Chuang Tzu, fora a distância cronológica de vinte e quatro séculos, apresenta bastantes dificuldades para o leitor ocidental por integrar a tradição oriental de pensamento. Trabalhar-se-á com versões de Thomas Merton. Será estabelecido um confronto entre a visão poética de Chuang Tzu, que remete a uma desfuncionalização da vida e do ser humano, e a percepção corrente na sociedade globalizada, que gira em torno da utilidade e funcionalidade, ponto máximo e atual da tradição metafísica do Ocidente.

[1] Pensador chinês do século IV a.C., de inspiração taoísta.
A importância da criatividade computacional para a literatura generativa: reflexões sobre arte, ciência e tecnologia na ciberliteratura
Authors: Veronese Thalita 
Published: May 2021

Desde o surgimento da arte-técnica, a visão da arte como coisa exclusivamente humana alimenta as críticas em relação à interferência da ciência e da tecnologia sobre a criação artística. Mais recentemente, a arte gerada por computadores, aqui chamada arte generativa, trouxe novos elementos a essa discussão e tem levado, como em outros momentos da história, ao questionamento do papel do artista e de sua relação com a obra e com o público. Este artigo levanta perspectivas sobre a arte e, mais especificamente, a literatura generativa sob os aspectos da Criatividade Computacional.
Être « Métis » : identification et représentation dans la société canadienne; contenant une entrevue avec David Bouchard
Authors: Boteva Lidiya 
Published: May 2021

Comment s’identifier de nos jours à une culture unique quand, pendant des générations, la fusion de différents peuples a été le déroulement de la croissance d’une population? Un article de Simon Villeneuve sert de base à l’étude complexe sur les Métis du Québec et à leur statut au sein de la loi canadienne. Il est pertinent d’envisager la diffusion de l’image métisse à travers l’éducation.
L’un des conférencier et auteur de plus de soixante-dix ouvrages consacrés à la culture métisse au Canada, David Bouchard, a eu la gentillesse de partager sa vision de ce que signifie être Métis et comment diffuser et enseigner la culture autochtone.
Ipséités/identités multiples et polyphonie linguistique dans Anima de Wadji Mouawad
Authors: Baldé Mamadou Lamine 
Published: May 2021

Résumé : L’expérience de l’exil a mis fin à la conception d’une identité unique chez Wadji Mouawad. Québécois d’origine libanaise, Mouawad est un écrivain à cheval entre diverses cultures. Son roman Anima (2012) recourt à un français qui cohabite avec l’anglais, l’arabe et le latin, probablement, pour investir sa propre culture en mouvement. Quand le héros du roman, Wahhch, emprunte le même trajet (né au Liban, exilé au Québec), le rapprochement s’établit. Mais quand l’auteur lui donne la possibilité de croiser d’autres personnages dans le vaste espace nord-américain (Canada et États-Unis), les ipséités (identités propres ou personnelles) sont mises en œuvre au même titre que leurs identités multiples (entre Libanais, Français, Canadiens, Américains…). L’étude du roman interroge la francophonie de Mouawad comme construite sur des cultures et des langues mouvantes.
Restitutions et gémellité
Authors: Woodward Servanne 
Published: May 2021

L’absence se trouve au centre de ce recueil d’articles, qu’il s’agisse de l’histoire débalancée qui minimise celle des communautés ou des êtres minorisés. L’effacement identitaire semble cependant réunir les autochtones comme les diverses vagues d’immigrations canadiennes qui vivent d’autres sortes de hiatus culturel. Il s’agit alors de devenir passeurs de mémoire et/ou de « renaître ».
Expressions indécentes et libération de la parole chez Nelly Arcan
Authors: Thior Mariama 
Published: May 2021

L’écriture est un moyen par lequel toutes les personnes dépassées par un fait quelconque, d’une réalité dérangeante, ont la possibilité de s’en servir pour mettre à nu certaines tares de la société, dénoncer des injustices en rapport avec la vie quotidienne des individus de façon globale. Quant à Nelly Arcan, son projet d’écriture a une visée d’ordre psychologique et personnel, c’est-à-dire une lutte qui a pour ambition une libération de soi et ou une quête perpétuelle d’une beauté hallucinante à l’image de la Scrhtroumfett. Ainsi, pour atteindre son objectif, elle est passée par la révolte qui sous-tend une écriture crue, un style débridé, l’expression libre, le langage lascif qui dépasse l’imaginaire d’un lecteur et d’une lectrice non avertis. C’est dans ce sillage que s’inscrivent ces trois premiers romans considérés comme une trilogie, Putain[1], A ciel ouvert[2] et Folle. En effet, elle y dévoile toute sa hantise, son dégoût à l’égard des hommes, sa dislocation avec son père, le silence coupable de sa mère, la beauté artificielle et ses nombreux déboires, etc. Voilà autant de préoccupations notoires que pose la romancière québécoise dans ses productions et celles-ci ont attisé, bien évidemment notre curiosité au point de vouloir décrypter dans cet article, et ce, au fil de l’analyse, toutes les pistes possibles pour comprendre son choix d’écriture et l’entêtement qui en découle.
Rapport (I) sur la collection John Davis Barnett à la bibliothèque Weldon : Les deux premiers livres publiés à Montréal (chez Fleury Mesplet), en 1776
Authors: De Viveiros Geneviève , Woodward Servanne 
Published: May 2021

Information sur les deux premiers livres en français publiés à Montréal ; pour l’éducation par le théâtre religieux des collèges catholiques pour les garçons (l’auteur du Journal de Trévoux) et un livre de règlements de la confrérie de la Bonne Mort. Ces ouvrages font partie de la collection des livres rares de la bibliothèque Weldon de l’Université Western, et ils ont été donnés en 1918 par John Davis Barnett. Ce geste fondateur reste encore inexploré, ainsi que sa logique de collectionneur bibliophile, sans parler de son innombrable collection. Fleury Mesplet a également publié des guides de prière en langue iroquoise.
Galambos v Perez, its Critics, and the Equity-Certainty Paradox in Fiduciary Law
Authors: DeWolfe Calvin 
Published: May 2021

This paper examines the merits of the current approach to identifying ad hoc fiduciary duties in Canada, which was exposited by the Supreme Court of Canada in its 2009 Galambos v Perez decision. The indicia of fiduciary relationships expressed in Galambos, I argue, are sufficiently comprehensive and certain to overcome popular academic criticisms of the indicia-based ad hoc approach. Specifically, I will challenge the arguments of the contractarian scholar Anthony Duggan and the equity-focused scholar Leonard Rotman -- both of which argue, albeit from different ends of the academic spectrum, that ad hoc fiduciary duties should not be identified using indicia.
Cancer among Indigenous Communities: Disparities & Challenges
Authors: Mishra Anamika , Shi Nancy 
Published: May 2021

Given the history of racism and systemic oppression of Indigenous communities, examining and addressing health inequities in in Indigenous continues to be relevant and important. An increasing number of healthcare problems are emerging from Indigenous communities.1,2 Canadian First Nations women and men have lower life expectancies and increasing rates of chronic conditions, such as diabetes, cardiovascular diseases, heart disease, and obesity.1 Some evidence suggests that the burden of cancer is lower among Indigenous communities than the overall population.3 However, there is much data indicating that this rate in increasing and that members of Indigenous communities have increased mortality rates when compared to non-Indigenous groups for cancers of the cervix, breast, gallbladder, lip and oropharynx, liver, lung, prostate and stomach.4,5 This paper discusses cancer incidence, risk factors, screening, and detection of cancers among Indigenous communities. This is followed by a discussion of potential interventions that may reduce the burden-related morbidity and mortality of cancer on these communities. Indigenous communities continue to experience unique barriers to accessing appropriate cancer care and preventive services and steps to minimize health inequalities should be taken.
A Delayed Presentation of Diffuse Axonal Injury
Authors: Wunder Meaghan , Ruicci Kara 
Published: May 2021

Diffuse axonal injury is one of the most common and debilitating pathologies resulting from mechanical deformation of the brain. The current case involves a 19-year-old female involved in a high velocity ski crash. The accident resulted in a right lower leg fracture, with no loss of consciousness or evidence of head trauma. Approximately 6.5 hours after her admission, the neurological status of the patient deteriorated markedly, and magnetic resonance imaging findings were consistent with diffuse axonal injury. This presentation illustrates a case of delayed diffuse axonal injury, a phenomenon not commonly described. Diffuse axonal injury involves rapid inertial forces causing strain to brain tissue. This strain results in various stages of diffuse axonal damage and inflammation. This article highlights a case of delayed onset diffuse axonal injury, describes the progression of neural sequelae post-injury resulting in axonal damage and explores proposed therapeutic targets.