bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doświadczenia „wygnańcze” ludności jako skutek działań militarnych na Półwyspie Iberyjskim w okresie średniowiecza
Authors: Niewiński Andrzej 
Published: October 2021

Ciągle trwające przez kilka stuleci działania militarne w okresie dominacji muzułmańskiej, a następnie stopniowego odzyskiwania terytoriów przez chrześcijan skutkowały utworzeniem się społeczeństwa zmilitaryzowanego (szczególnie w obszarach przygranicznych), którego codzienną egzystencję cechował duży stopień zagrożenia i niepewności. Towarzyszyły temu takie zjawiska, jak ucieczka, wygnanie, wysiedlenie, emigracja, wyludnienie uprzednio zamieszkanych obszarów.
Największe straty ponosiła ludność zamieszkująca obszary wiejskie – konieczność częstej zmiany miejsc zamieszkania skutkowała wyjałowieniem ziemi uprawnej. Ciągłe zmiany powodowała trwająca rekonkwista. W sytuacji, gdy władca chrześcijański nie pozwalał muzułmanom na opuszczenie zdobytego przez siebie terytorium, rozpowszechniała się nielegalna emigracja. Z kolei wypędzenie muzułmanów z terenów odzyskanych stwarzało konieczność zasiedlenia tych miejscowości przez ludność chrześcijańską, do czego zachęcano m.in. za pomocą przywilejów. Część miejscowości jednak po ich opuszczeniu pozostawała niezamieszkana. Uchodźstwo bywało skutkiem najazdu (uchodźcy szukali schronienia w górach i twierdzach, gdzie następnie próbowali stawiać opór, bądź po prostu szukali bezpieczniejszego miejsca zamieszkania), ciężkich warunków życia lub epidemii (np. dżumy, która zdziesiątkowała ludność w XIV wieku). Jeszcze innym doświadczeniem wygnańczym był los jeńców, którzy mogli zostać sprzedani jako niewolnicy i wywiezieni do innego kraju lub byli zmuszeni do niewolniczej pracy, która stanowiła równowartość okupu i stwarzała możliwość odzyskania wolności.
Blenderized Tube Feeding in Pediatric Patients: A Systematic review
Authors: Bahramian Behnam , Talebi Saeedeh , Rezaie Mitra 
Published: October 2021

Background: Enteral feeding (EF) is the delivery of liquid nutritional support through a tube for hospitalized patients with gastrointestinal dysfunction who are incapable of eating or unable to meet their nutritional requirements via the oral route. Hospitals’ reports indicate an increased interest and demand for blenderized tube feeding (BTF) as an alternative to commercial enteral formulas particularly in families of tube fed children. In particular, by increasing food sensitivity and more complex identification in children, BTF allows families to adjust their diet to their children's needs. This systematic review aimed to summarize the published evidence regarding BTF in pediatric patients.
Methods: Literature search was conducted in four databases, including Scopus, PubMed, Science Direct, and Google Scholar, using multiple keywords, such as blenderized tube feeding, blended formula, homemade enteral nutrition, pediatric, and children. Out of 103 retrieved articles, 6 were selected and reviewed.
Results: Six articles were eligible to be included in the current review. The results showed that calories were approximately 1kcal/g, protein 13 -22%, fat 30 - 34%, and carbohydrates intake 45-55% of total energy intake.
Conclusions: The results indicated that BTF is acceptable and can be administered to children; however, due to concerns about calorie and macronutrients deficiency, it should be providing under the supervision of a nutritionist. BTFs are a good choice among children; since they can improve gastrointestinal symptoms and are a good option for families who use EF for their children at home. Most pediatric patients use BTFs as a portion of their EF, making it necessary that nutritionists and physicians expand their knowledge about BTFs to appropriately care for these pediatric patients.
Development of Human Resources in Android-based Information System for People with Social Welfare Problems
Authors: Arman Arman , Alang Alang , Malago Yusrianto 
Published: October 2021

The problem in this study is that the process of data collection and final report of Persons with Social Welfare Problems has not been computerized properly so that the process of procurement of goods and distribution of assistance for has not been effective and well target. With the aim of his research To simplify the data collection process and final report so that the process of procurement of goods and distribution of aid is more effective and on target. The object of this research is the Procurement Information System and Distribution of Assistance for Persons with Social Welfare Problems in the Gorontalo-based Gorontalo City Social Service with the method used in designing this information system is a descriptive method that is research aimed at solving problems systematically and factually about the facts studied. The design phase includes, model design, output design, Input design, database design and technology design, to the system testing stage. Analysis of the data where the data obtained in the field will be analyzed in a qualitative manner. Qualitative analysis is used to describe the efforts made in the form of human resource development in the information service system of assistance for people with problems based on android-based social welfare towards smart city. The results obtained show that the application can be made and used.
Efficient PDC Bit Designs Reduced Vibrational Impact While Drilling with Rotary Steerable Systems in the Geological Conditions of the Yamalo-Nenets Autonomous District
Authors: Garipov Andrey Vyacheslavovich , Rebrikov Andrey Aleksandrovich , Galimkhanov Aydar Ramilevich , Mikhaylov Andrey Valerievich , Khalilov Almaz Sadrikhanovich , Kochetkov Denis Sergeevich , Tur Dmitry Yurievich , Yavorsky Aleksandr Aleksandrovich , Maltsev Vladimir Aleksandrovich , Rybalkin Alexey Aleksandrovich , Pogurets Valery Viktorovich , Zolotenkov Viktor Vyacheslavovich , Levitskiy Daniil Nikolaevich 
Published: October 2021

Abstract
This article is a description of a comprehensive engineering approach to new designs of PDC (Polycrystalline Diamond Compact) Bits and bottomhole equipment for efficient horizontal wells drilling in the Yamal-Nenets Autonomous Okrug (YNAO) fields with Rotary Steerable Systems (RSS) Point the Bit (PTB) type. The paper represents an analysis of the efficiency of drilling rocks of various hardness depending on the bits, the bottom hole assembly (BHA), and type of vibrations.
In the Yamal region fields a main constraint of sub horizontal sections drilling performance for liner run in hole is the occurrence of vibrations. The predominant vibration types are Stick and Slip (S&S) and High Frequency Torsional Oscillations (HFTO). These types of vibrations often had to be reduced by limiting drilling regime (weight on bit (WOB), drill pipe (DP) RPM, and flow rate), which directly affected on the rate of penetration (ROP).
To find solutions to this problem for drilling performance improvement, geological and geomechanically modeling of rock properties and an analysis of burst-files of vibrations (modeled in specialized software) were carried out based on downhole data. The studies have found key factors that cause the high vibration impact and reasons for premature wear of the PDC bits, which served as a basis for identifying the shortcomings of previous bit designs. Test beam experiments were also performed to assess the bits wear while drill-out of the casing accessories. The results formed the basis for development of new PDC bits designs using specialized software.
As an output new 155.6/152.4 mm bits designs with an innovative cutting structure that considers the geological features and technical aspects of drilling liner sections in YNAO fields were manufactured.
The new bit designs have significantly reduced vibration levels, improved ROP performance in the liner section using RSS PTB, and decreased the overall well construction time. These solutions open wide opportunities for their further implementation on other projects both in Russia and in other CIS countries.
Joanne Knight Breast Health Cohort at Siteman Cancer Center: A model last cohort
Authors: Colditz Graham A. , Bennett Debbie L , Tappenden Jenifer , Beers Courtney , Ackermann Nicole , Wu Ningying , Luo Jingqin , Humble Sarah , Linnenbringer Erin , Davis Kia , Jiang Shu , Toriola Adetunji 
Published: October 2021

Abstract
PurposeThe Joanne Knight Breast Health Cohort was established to link breast cancer risk factors, mammographic breast density, benign breast biopsies and associated tissue markers, and blood markers in a diverse population of women undergoing routine mammographic screening.MethodsWomen were recruited from November 2008 to April 2012. Baseline questionnaire risk factors, blood, and screening mammograms were collected from 12,153 women. Of these, 1,672 were excluded for prior history of any cancer (except non-melanoma skin) or diagnosis of breast cancer within 6 months of blood draw/registration for the study, for a total of 10,481 women. Follow-up is through linking to electronic health records, tumor registry and death register. Routine screening mammograms are collected every 1 to 2 years and incident benign breast biopsies and cancers are identified through record linkage to pathology and tumor registries. Formal fixed tissue samples are retrieved and stored for analysis. County-level measures of structural inequality were derived from publicly available resources.ResultsCohort Composition: median age at entry was 54.8 years and 26.7% are African American. Through 2020, 74 percent of participants have had a medical center visit within the past year and 80% within the past 2 years representing an average of 9.7 person years of follow-up from date of blood draw per participant. 9,997 women continuing in follow-up. Data collected at baseline include breast cancer risk factors, baseline plasma and white blood cells, mammograms prior to baseline, at baseline, and during follow-up. ConclusionThis cohort assembled and followed in a routine clinical screening and care setting that serves a diverse population of women in the St Louis region, now provides opportunities to integrate study of questionnaire measures, plasma and DNA markers, benign and malignant tissue markers, and breast image features into prospective evaluation for breast cancer etiology and outcomes.
Health Literacy and Behaviour among Pregnant Women with Obesity: A Qualitative Interpretive Description Study
Authors: Meldgaard Maiken , Jensen Annesofie Lunde , Johansen Amalie Damgaard , Maimburg Rikke Damkjaer , Maindal Helle Terkildsen 
Published: October 2021

Abstract
Background: Obesity in pregnant women is increasing worldwide, affecting the health of both mother and baby. Obesity may be associated with inadequate health literacy, a central competence when navigating antenatal health information and services. This study explores women’s health literacy experiences among a sample of pregnant women with a prepregnant body mass index (BMI) >25 kg/m2.Methods: An inductive, qualitative study using an interpretive description methodology. Data was collected through ten semi-structured interviews with pregnant women with a prepregnancy BMI >25 kg/m2 attending antenatal care at the midwifery clinic at Aarhus University Hospital in the Central Denmark Region.Results: Pregnant women with obesity understand general health information provided by health professionals, but translating this knowledge into specific healthy behaviours presents a challenge. Although difficulties navigating booking systems and available digital services contribute to this problem, apps can help facilitate navigation. However, successful navigation may depend on adequate e-health literacy. Conflicting information from health professionals, social media and families also present a challenge for pregnant women, requiring a broad skillset for critical evaluation and resolution.Conclusions: Adequate health literacy is necessary for pregnant women receiving antenatal care to (i) translate general health information into personalised healthy behaviour, (ii) access and navigate complex and digitalised systems, and (iii) critically evaluate conflicting information. Person-centred differentiation in the organisation of antenatal care may benefit vulnerable pregnant women with inadequate health literacy.Trial registration: The study was registered cf. General Data Protection Regulation, Aarhus University Journal number 2016-051-000001, serial number 1934.
Joint Modeling of Repeated Measurements of Different Biomarkers Predicts Mortality in COVID-19 Patients in the Intensive Care Unit.
Authors: Tong-Minh Kirby , Does Yuri van der , Rosmalen Joost van , Ramakers Christian , Gommers Diederik , Gorp Eric van , Rizopoulos Dimitris , Endeman Henrik 
Published: October 2021

Abstract
BackgroundPredicting disease severity is important for treatment decisions in patients with COVID-19 in the intensive care unit (ICU). Different biomarkers have been investigated in COVID-19 as predictor of mortality, including C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and soluble urokinase-type plasminogen activator receptor (suPAR). Using repeated measurements in a prediction model may result in a more accurate risk prediction than the use of single point measurements. The goal of this study is to investigate the predictive value of trends in repeated measurements of CRP, PCT, IL-6 and suPAR on mortality in patients admitted to the ICU with COVID-19. MethodsThis was a retrospective single center cohort study. Patients were included if they tested positive on SARS-CoV-2 by PCR test and if IL-6, PCT, suPAR was measured during any of the ICU admission days. There were no exclusion criteria for this study. We used joint models to predict ICU-mortality. This analysis was done using the framework of joint models for longitudinal and survival data. The reported hazard ratios express the relative change in the risk of death resulting from a doubling or 20% increase of the biomarker’s value in a day compared to no change in the same period. ResultsA total of 107 patients were included, of which 26 died during ICU admission. Adjusted for sex and age, a doubling in the next day in either levels of PCT, IL-6 and suPAR was significantly predictive of in-hospital mortality with and an HR of 1.523 (1.012 – 6.540), 75.25 (1.116 – 6247) and 24.45 (1.696 – 1057) respectively. With a 20% increase in biomarker value in a subsequent day, the HR of PCT, IL-6 and suPAR were 1.117 (1.03 – 1.639), 3.116 (1.029 – 9.963) and 2.319 (1.149 – 6.243) respectively.ConclusionJoint models for the analysis of repeated measurements of PCT, suPAR and IL-6 are a useful method for predicting mortality in COVID-19 patients in the ICU. Patients with an increasing trend of biomarker levels in consecutive days are at increased risk for mortality.
Effects of Water and Salt Movement On Photosynthetic Production Characteristics and Yield Formation of Cotton On Coastal Saline Land
Authors: Feng Guoyi , Zhang Qian , Sun Chitao , Lei Xiaopeng , Wang Shulin , Wang Yan , Dong Ming , Liang Qinglong , Lin Yongzeng , Qi Hong 
Published: October 2021

Abstract
Background
In order to study the effects of spatial distribution and yearly migration variations of soil water and salt in coastal saline land on photosynthetic production and yield formation of cotton, spatial distribution characteristics of water content, salinity, and pH in soil at 0–200 cm depths in 3 cotton fields that were similar in locality but differed markedly in degree of salinization were determined in April through October, and photosynthetic characteristics and photosynthate accumulation of cotton were also determined.
Results
The study shows that, the slightly salinized cotton field had lower soil salinity and pH, where soil water content was lower in rainy season (July–August), and at the late reproductive stage (September–October), soil water content was markedly higher than that in the moderately salinized cotton field, where cotton suffered smaller salt-alkali stress, photosynthetic production matched well with hydrothermal resource, the sink organ had a long photosynthate accumulation time and was at the active material accumulation stage for a long time; salt-alkali stress to the moderately salinized cotton field was relieved in rainy season, but at the early reproductive stage (April–June) and the late reproductive stage of cotton, salt-alkali stress remained evident, and photosynthetic production fit more poorly with the rich photothermal resource stage; the severely salinized cotton field subjected to prolonged high salt-alkali stress resulted in low levels of photosynthetic production capacity and yield.
Conclusions
For the severely salinized cotton field, salt inhibition and other relevant agronomic actions should be taken with greater efforts; for the moderately salinized cotton field, water and fertilizer management should be tightened at the early reproductive stage of cotton; for the slightly salinized cotton field, high-quality efficient cotton production should be developed.
Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha (TOP2A) in Human Malignances: A Pan-Cancer Analysis
Authors: Zhao Fulai , Chang Junli , Wang Wenyi , Sun Xingyuan , Ma Xiaoping , Zhao Peng , Wang Yongjun , Yang Yanping 
Published: October 2021

Abstract
Increasing studies have revealed significant associations between TOP2A with oncogenesis and prognosis of human cancers; however, pan-cancer analysis has not been reported. Here, we explored the potential carcinogenic function, the association with clinical outcomes of TOP2A in 33 different human cancers. The results showed that TOP2A was amplified in 32 investigated cancers; TOP2A expression was significantly associated with metastasis of six different cancers, and significantly associated with the survivals of patients in ten different cancers; TOP2A encoded protein was obviously upregulated in five available cancers; phosphorylated TOP2A protein at S1106 was significantly upregulated in all six available cancers. Moreover, TOP2A expression was found to be associated with the cancer-associated immune cell infiltration, including fibroblasts, Tregs and macrophages. In addition, Kyoto encyclopedia of genes and genomes (KEGG) pathway and Gene Ontology (GO) enrichment analyses revealed a most significant association between TOP2A with Wnt signaling pathway, and DNA conformation change. This work provides a comprehensive knowledge of TOP2A in different cancers, including carcinogenic function, prognostic values for metastasis and clinical outcomes.
Clinical Use of Lymphocyte Subset Analysis: As a Prognostic Marker for Dogs with Pyometra
Authors: Yokota Shunya , YUKI Masashi , Fujikake Kohei , Masuda Kenichi , Hirano Takashi , Naito Eiji , Kainuma Daiki , Taira Hiroto , Narita Momoko 
Published: October 2021

Abstract
BackgroundLymphocyte subset analysis is clinically applied in human medicine. However, lymphocyte subset analysis is rarely used in small animal practice. We hypothesized that lymphocyte subsets analysis was useful in small animal practice as a biomarker for evaluating immune competence and predicting the disease prognosis. Lymphocyte subset analysis was performed prospectively for pyometra, a common disease in dogs, to assess its clinical usefulness in small animal practice.ResultsThis study included 29 dogs diagnosed with pyometra. They were classified into group 1 and group 2 on the basis of clinical course postoperatively. Sixteen dogs were classified in group 1 with no adverse events postoperatively. Thirteen dogs experienced adverse events such as increase in C-reactive protein concentration and white blood cell count, discharge from operation site, and hypoglycemia. These dogs were classified as group 2. Nine dogs were below the reference interval for the lymphocyte subset, eight of which were in group 2. Group 2 included significantly more dogs with lymphocyte subset abnormalities (p = 0.005). In the multivariable logistic regression analysis, only the result of lymphocyte subset analysis was significantly associated with adverse events (p = 0.02, 95% confidence interval = 1.68–192). Most dogs in group 2 were successfully treated.ConclusionsThese results indicate that lymphocyte subset analysis is useful as a prognostic tool for pyometra. Further studies are necessary for evaluating the clinical usefulness of lymphocyte subset analysis in pyometra and other diseases.
Effect of ZrO2 Doping on the Microstructure and Dielectric Properties of Ca0.97Y0.03Cu3Ti4-xZrxO12 Ceramics
Authors: YU Haibo , WEI Yanliang , ZHANG Xiaolin , WANG Dang , ZHANG Yuying , CHU Ruiqing , Xu Zhijun 
Published: October 2021

Abstract
Dielectric properties of CaCu3Ti4O12 (CCTO) ceramics were studied by doping amount of Zr4+ donor on the basis of doping Y3+ donor. Ca0.97Y0.03Cu3Ti4-xZrxO12 (x=0, 0.005, 0.010, 0.015, CYCTZO) ceramics were prepared by reaction sintering method, and the phase structure, microstructure and dielectric properties of the ceramics were studied. The single phase CCTO was detected in all ceramic samples. SEM images of samples showed a high density and uniform-sized microstructure, and the average grain sizes of the ceramics was reduced with increasing content of Zr4+ donor. Interestingly, the dielectric constant (εr) was increased significantly while the dielectric loss tangent (tanδ) was decreased with the suitable doping amount of Zr4+. CYCTZO ceramics with x=0.010 exhibited a relatively high εr value of 1.02×105 at 1kHz. Meanwhile, the improved grain boundaries response and dielectric properties were closely related to the strengthened grain boundaries resistance (Rgb). The present results indicate that the εr was improved and the tanδ was reduced by doping Zr4+ donors in Ca0.97Y0.03Cu3Ti4O12 (CYCTO) ceramics and explained that the electrical properties were closely related to the electrical heterogeneity of ceramic grains and grain boundaries.
COX-2/sEH Dual Inhibitor PTUPB Inhibits Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells by Suppressing TGF-β1-Smad2/3 Signaling Pathway
Authors: Zhang Chen-Yu , Guan Xin-Xin , Song Zhuo-Hui , Jiang Hui-Ling , Liu Yu-Biao , Chen Ping , Duan Jia-Xi , Zhou Yong 
Published: October 2021

Abstract
Background: Arachidonic acid (ARA) metabolites are involved in the pathogenesis of epithelial-mesenchymal transformation (EMT). However, the role of ARA metabolism in the progression of EMT in pulmonary fibrosis (PF) has not been fully elucidated. The purpose of this study was to investigate the role of cytochrome P450 oxidase (CYP)/ soluble epoxide hydrolase (sEH) and cyclooxygenase-2 (COX-2) metabolic disorders of ARA in EMT during PF.Methods: A signal intratracheal injection of bleomycin (BLM) was given to induce PF in C57BL/6J mice. A COX-2/sEH dual inhibitor PTUPB was used to establish the function of CYPs/COX-2 dysregulation to EMT in PF mice. In vitro experiments, murine alveolar epithelial cells (MLE12) and human alveolar epithelial cells (A549) were used to explore the roles and mechanisms of PTUPB on transforming growth factor (TGF)-β1-induced EMT. Results: PTUPB treatment reversed the increase of mesenchymal marker molecule α-smooth muscle actin (α-SMA) and the loss of epithelial marker molecule E-Cadherin in lung tissue of PF mice. In vitro, COX-2 and sEH protein levels were increased in TGF-β1-treated alveolar epithelial cells (AECs). PTUPB decreased the expression of α-SMA and restored the expression of E-cadherin in TGF-β1-treated AECs, accompanied by reduced migration and collagen synthesis. Moreover, PTUPB alleviated the activation of the TGF-β1-Smad2/3 pathway induced by TGF-β1 in AECs.Conclusion: PTUPB inhibits TGF-β1-induced EMT via inhibition of the TGF-β1-Smad2/3 pathway, which holds great promise for the clinical treatment of PF.