bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dry Needling for the Treatment of Tension-Type, Cervicogenic, or Migraine Headaches: A Systematic Review and Meta-Analysis
Authors: Pourahmadi Mohammadreza , Dommerholt Jan , Fernández-de-Las-Peñas César , Koes Bart Willem , Mohseni-Bandpei Mohammad Ali , Mansournia Mohammad Ali , Delavari Somayeh , Keshtkar Abbasali , Bahramian Mehrdad 
Published: February 2021

Abstract

Objective
Dry needling is a treatment technique used by clinicians to relieve symptoms in patients with tension-type headache (TTH), cervicogenic headache (CGH), or migraine. This systematic review’s main objective was to assess the effectiveness of dry needling on headache pain intensity and related disability in patients with TTH, CGH, or migraine.

Methods
Medline/PubMed, Scopus, Embase, PEDro, Web of Science, Ovid, Allied and Complementary Medicine Database/EBSCO, Cochrane Central Register of Controlled Clinical Trials, Google Scholar, and trial registries were searched until April 1, 2020, along with reference lists of eligible studies and related reviews. Randomized clinical trials or observational studies that compared the effectiveness of dry needling with any other interventions were eligible for inclusion. Three reviewers independently selected studies, extracted data, and assessed risk of bias. Random-effects meta-analyses were performed to produce pooled-effect estimates (Morris dppc2) and their respective CIs.

Results
Of 2715 identified studies, 11 randomized clinical trials were eligible for qualitative synthesis and 9 for meta-analysis. Only 4 trials were of high quality. Very low-quality evidence suggested that dry needling is not statistically better than other interventions for improving headache pain intensity in the short term in patients with TTH (SMD −1.27, 95% CI = −3.56 to 1.03, n = 230), CGH (SMD −0.41, 95% CI = −4.69 to 3.87, n = 104), or mixed headache (TTH and migraine; SMD 0.03; 95% CI = −0.42 to 0.48, n = 90). Dry needling provided significantly greater improvement in related disability in the short term in patients with TTH (SMD −2.28, 95% CI = −2.66 to −1.91, n = 160) and CGH (SMD −0.72, 95% CI = −1.09 to −0.34, n = 144). The synthesis of results showed that dry needling could significantly improve headache frequency, health-related quality of life, trigger point tenderness, and cervical range of motion in TTH and CGH.

Conclusions
Dry needling produces similar effects to other interventions for short-term headache pain relief, whereas dry needling seems to be better than other therapies for improvement in related disability in the short term.

Impact
Although further high-methodological quality studies are warranted to provide a more robust conclusion, our systematic review suggested that for every 1 or 2 patients with TTH treated by dry needling, 1 patient will likely show decreased headache intensity (number needed to treat [NNT] = 2; large effect) and improved related disability (NNT = 1; very large effect). In CGH, for every 3 or 4 patients treated by dry needling, 1 patient will likely exhibit decreased headache intensity (NNT = 4; small effect) and improved related disability (NNT = 3; medium effect).
Relationships Between Stepping-Reaction Movement Patterns and Clinical Measures of Balance, Motor Impairment, and Step Characteristics After Stroke
Authors: Pollock Courtney L , Hunt Michael A , Garland S Jayne , Ivanova Tanya D , Wakeling James M 
Published: February 2021

Abstract

Objective
Successful stepping reactions, led by either the paretic or nonparetic leg, in response to a loss of balance are critical to safe mobility poststroke. The purpose of this study was to measure sagittal plane hip, knee, ankle, and trunk kinematics during 2-step stepping reactions initiated by paretic and nonparetic legs of people who had stroke and members of a control group.

Methods
Principal component analysis (PCA) was used to reduce the data into movement patterns explaining interlimb coordination of the stepping and stance legs. Correlations among principal components loading scores and clinical measures of balance ability (as measured on the Community Balance and Mobility scale), motor impairment (as measured on the foot and leg sections of the Chedoke-McMaster Stroke Assessment), and step characteristics (length and velocity) were used to examine the effect of stroke on stepping reaction movement patterns.

Results
The first 5 principal components explained 95.9% of the movement pattern of stepping reactions and differentiated between stepping reactions initiated by paretic legs, nonparetic legs, or the legs of controls. Moderate-strong associations (ρ/r &gt; 0.50) between specific principal component loading scores and clinical measures and step characteristics were dependent on the initiating leg. Lower levels of motor impairment, higher levels of balance ability, and faster and longer steps were associated with stepping reactions initiated by the paretic leg that comprised paretic leg flexion and nonparetic leg extension. Step initiation with the nonparetic leg showed associations between higher scores on clinical measures and movement patterns of flexion in both paretic and nonparetic legs.

Conclusions
Movement patterns of stepping reactions poststroke were influenced by the initiating leg. After stroke, specific movement patterns showed associations with clinical measures depending on the initiating leg, suggesting that these movement patterns are important to retraining of stepping reactions. Specifically, use of flexion patterning and assessment of between-leg pattern differentiation may be important aspects to consider during retraining of stepping reactions poststroke.

Impact
Evidence-based interventions targeting balance reactions are still in their infancy. This investigation of stepping reactions poststroke addresses a major gap in research.
Exploring research impact models: A systematic scoping review
Authors: Razmgir Maryam , Panahi Sirous , Ghalichi Leila , Mousavi Seyed Ali Javad , Sedghi Shahram 
Published: February 2021

AbstractThis article explores the models and frameworks developed on “research impact’. We aim to provide a comprehensive overview of related literature through scoping study method. The present research investigates the nature, objectives, approaches, and other main attributes of the research impact models. It examines to analyze and classify models based on their characteristics. Forty-seven studies and 10 reviews published between 1996 and 2020 were included in the analysis. The majority of models were developed for the impact assessment and evaluation purposes. We identified three approaches in the models, namely outcome-based, process-based, and those utilized both of them, among which the outcome-based approach was the most frequently used by impact models and evaluation was considered as the main objective of this group. The process-based ones were mainly adapted from the W.K. Kellogg Foundation logic model and were potentially eligible for impact improvement. We highlighted the scope of processes and other specific features for the recent models. Given the benefits of the process-based approach in enhancing and accelerating the research impact, it is important to consider such approach in the development of impact models. Effective interaction between researchers and stakeholders, knowledge translation, and evidence synthesis are the other possible driving forces contributing to achieve and improve impact.
A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies
Authors: Oldroyd Alexander G S , Allard Andrew B , Callen Jeffrey P , Chinoy Hector , Chung Lorinda , Fiorentino David , George Michael D , Gordon Patrick , Kolstad Kate , Kurtzman Drew J B , Machado Pedro M , McHugh Neil J , Postolova Anna , Selva-O’Callaghan Albert , Schmidt Jens , Tansley Sarah , Vleugels Ruth Ann , Werth Victoria P , Aggarwal Rohit 
Published: February 2021

AbstractObjectivesTo identify clinical factors associated with cancer risk in the idiopathic inflammatory myopathies (IIMs) and to systematically review the existing evidence related to cancer screening.MethodsA systematic literature search was carried out on Medline, Embase and Scopus. Cancer risk within the IIM population (i.e. not compared with the general population) was expressed as risk ratios (RR) for binary variables and weighted mean differences (WMD) for continuous variables. Evidence relating to cancer screening practices in the IIMs were synthesized via narrative review.ResultsSixty-nine studies were included in the meta-analysis. DM subtype (RR 2.21), older age (WMD 11.19), male sex (RR 1.53), dysphagia (RR 2.09), cutaneous ulceration (RR 2.73) and anti-transcriptional intermediary factor-1 gamma positivity (RR 4.66) were identified as being associated with significantly increased risk of cancer. PM (RR 0.49) and clinically amyopathic DM (RR 0.44) subtypes, Raynaud’s phenomenon (RR 0.61), interstitial lung disease (RR 0.49), very high serum creatine kinase (WMD −1189.96) or lactate dehydrogenase (WMD −336.52) levels, and anti-Jo1 (RR 0.45) or anti-EJ (RR 0.17) positivity were identified as being associated with significantly reduced risk of cancer. Nine studies relating to IIM-specific cancer screening were included. CT scanning of the thorax, abdomen and pelvis appeared to be effective in identifying underlying asymptomatic cancers.ConclusionCancer risk factors should be evaluated in patients with IIM for risk stratification. Screening evidence is limited but CT scanning could be useful. Prospective studies and consensus guidelines are needed to establish cancer screening strategies in IIM patients.
A review of group-based methods for teaching statistics in higher education
Authors: Jones Elinor , Palmer Tom 
Published: February 2021

AbstractThe teaching of statistics in higher education in the UK is still largely lecture based. This is despite recommendations such as those given by the American Statistical Association’s Guidelines for Assessment and Instruction in Statistics Education report that more emphasis should be placed on active learning strategies where students take more responsibility for their own learning. One possible model is that of collaborative learning, where students learn in groups through carefully crafted ‘problems’, which has long been suggested as a strategy for teaching statistics. In this article, we review two specific approaches that fall under the collaborative learning model: problem- and team-based learning. We consider the evidence for changing to this model of teaching in statistics, as well as give practical suggestions on how this could be implemented in typical statistics classes in higher education.
Desulfovibrio subterraneus sp. nov., a mesophilic sulfate-reducing deltaproteobacterium isolated from a deep siliceous mudstone formation
Authors: Ueno Akio , Tamazawa Satoshi , Tamamura Shuji , Murakami Takuma , Kiyama Tamotsu , Inomata Hidenori , Amano Yuki , Miyakawa Kazuya , Tamaki Hideyuki , Naganuma Takeshi , Kaneko Katsuhiko 
Published: February 2021

A novel mesophilic sulfate-reducing bacterium, strain HN2T, was isolated from groundwater sampled from the subsurface siliceous mudstone of the Wakkanai Formation located in Horonobe, Hokkaido, Japan. The bacterium was Gram-negative and vibrio-shaped, and its motility was conferred by a single polar flagellum. Cells had desulfoviridin. Catalase and oxidase activities were not detected. It grew in the temperature range of 25–40 °C (optimum, 35 °C) and pH range of 6.3–8.1 (optimum, pH 7.2–7.6). It used sulfate, thiosulfate, dimethyl sulfoxide, anthraquinone-2,6-disulfonate, Fe3+, and manganese oxide, but not elemental sulfur, nitrite, nitrate, or fumarate as electron acceptors. The strain showed weak growth with sulfite as the electron acceptor. Fermentative growth with pyruvate, lactate and cysteine was observed in the absence of sulfate, but not with malate or fumarate. NaCl was not required, but the strain tolerated up to 40 g l–1. Strain HN2T did not require vitamins. The major cellular fatty acids were iso-C15 : 0 (23.8 %), C18 : 1
ω9t (18.4 %), C18 : 0 (15.0 %), C16 : 0 (14.5 %), and anteiso-C17 :0 (10.1 %). The major respiratory quinone was menaquinone MK-6(H2). The G+C content of the genomic DNA was 56.7 mol%. Based on 16S rRNA gene sequence analysis, the closest phylogenetic relative of strain HN2T is

Desulfovibrio psychrotolerans

JS1T (97.0 %). Digital DNA–DNA hybridization (dDDH) and average nucleotide identity (ANI) values of the strains HN2T and

D. psychrotolerans

JS1T were 22.2 and 79.8 %, respectively. Based on the phenotypic and molecular genetic evidence, we propose a novel species, D. subterraneus sp. nov. with the type strain HN2T (=DSM 101010T=NBRC 112213T).
Top-down effects in motor generalization
Authors: Poh Eugene , Al-Fawakhiri Naser , Tam Rachel , Taylor Jordan A. , McDougle Samuel D. 
Published: February 2021

AbstractTo generate adaptive movements we must generalize what we have previously learned to novel situations. The generalization of adapted movements has typically been framed as a consequence of neural tuning functions that overlap for similar movement kinematics - what might be considered bottom-up generalization. However, as is true in many domains of human behavior, generalization can also be framed as the result of deliberate decisions about how to act (top-down generalization). Here we attempt to broaden the scope of theories about motor generalization, hypothesizing that part of the typical motor generalization function can be characterized as a consequence of top-down decisions concerning the subjective similarity of different movement contexts. We tested this proposal by having participants make explicit similarity ratings over both traditional kinematic contextual dimensions (movement direction) and more abstract contextual dimensions (target shape), and perform a visuomotor adaptation generalization task where trials varied over those dimensions. Across five experiments, we measured the relationship between subjective similarity ratings and motor generalization. In some cases this link was rather strong, though it was determined by both task-relevance and explicit instruction. These results support a broadening of the descriptive framework used to understand the generalization of motor behaviors and support a more careful deployment of instructions in generalization studies.Significance StatementGeneralization describes the transfer of knowledge from one context to another, and is typically thought to result from a higher-order inference process. However, in the motor adaptation domain, generalization is thought to arise from neural representations tuned to low-level kinematics. To bridge these differing views, we measured peoples’ subjective similarity judgements of different task contexts during sensorimotor adaptation. We found that motor generalization was closely linked to participant’s subjective judgements, and that explicit instructions about the consequential dimension of different contexts further shaped generalization. These findings emphasize that in addition to low level kinematic considerations, top-down inferences about which action to take in a given context should be considered as another key component of motor generalization.
How reacted USA with the first case of Bubonic Plague on 21 August?
Authors: Saire Josimar Edinson Chire , Cruz Jimy Oblitas 
Published: February 2021

AbstractThe present work studies the reactions of citizens from United States of America (USA) during the first cases of Bubonic Plague in the territory on August 2020, during pandemic generated by Covid-19. The interest of the study is analyze the posts of users from all the states of USA following a Text Mining approach. The collection of data is performed through Twitter Application Program Interface (API) of Twitter, considering keywords: bubonic plague and black death. The results show the states with highest number of coronavirus has more publication than others and the interest about treatments, political issues and public health.
SARS CoV-2 nucleoprotein enhances the infectivity of lentiviral spike particles
Authors: Mishra Tarun , Sreepadmanabh M , Ramdas Pavitra , Sahu Amit K , Kumar Atul , Chande Ajit 
Published: February 2021

AbstractThe establishment of SARS CoV-2 spike-pseudotyped lentiviral (LV) systems has enabled the rapid identification of entry inhibitors and neutralizing agents, alongside allowing for the study of this emerging pathogen in BSL-2 level facilities. While such frameworks recapitulate the cellular entry process in ACE2+ cells, they are largely unable to factor in supplemental contributions by other SARS CoV-2 genes. To address this, we performed an unbiased ORF screen and identified the nucleoprotein (N) as a potent enhancer of spike-pseudotyped LV particle infectivity. We further demonstrate that this augmentation by N renders LV spike particles less vulnerable to the neutralizing effects of a human IgG-Fc fused ACE2 microbody. Biochemical analysis revealed that the spike protein is better enriched in virions when the particles are produced in the presence of SARS CoV-2 nucleoprotein. Importantly, this improvement in infectivity is achieved without a concomitant increase in sensitivity towards RBD binding-based neutralization. Our results hold important implications for the design and interpretation of similar LV pseudotyping-based studies.
Fear and death anxiety among Latin American doctors during the Covid-19 pandemic
Authors: Indacochea-Cáceda Sonia , Torres-Malca Jenny Raquel , Vera-Ponce Víctor Juan , Pérez Miguel A. , De La Cruz-Vargas Jhony A. 
Published: February 2021

AbstractIntroductionA patient’s death elicits various feelings arise in doctors such as impotence and guilt that could trigger physical or psychological symptoms. Despite its impact, few studies have explored anxiety and fear of death among physicians.ObjectiveTo evaluate perceptions and responses to one’s mortality among Latin American physicians treating COVID-19 patients.MethodologyThis cross-sectional study utilized the Collet-Lester Modified Fear of Death Scale and the Death Anxiety Scale (DAS) to collect data from physicians in Latin America.Results219 doctors from Peru, Mexico, Argentina, Colombia, and Bolivia filled out the online questionnaire. Fear of death among the sample population ranged from 56.2% to 90%. Furthermore, the prevalence of “High Anxiety” was 80.8%. A statistically significant association was found between fear according to age and time of graduation (p = 0.010 and p = 0.020, respectively). No differences were found by gender, age, and country of origin or practice.ConclusionPhysicians experience feelings of helplessness and guilt upon the death of a patient and those feelings can trigger physical or psychological symptoms. For these states of fear and anxiety about death, more frequent in times of pandemic, doctors must be prepared, and institutions must provide them with the necessary means to help them overcome these difficult times.
LifeSim: A Lifecourse Dynamic Microsimulation Model of the Millennium Birth Cohort in England
Authors: Skarda Ieva , Asaria Miqdad , Cookson Richard 
Published: February 2021

AbstractWe present a dynamic microsimulation model for childhood policy analysis that models developmental, economic, social and health outcomes from birth to death for each child in the Millennium Birth Cohort (MCS) in England, together with public costs and a summary wellbeing measure. The model is a discrete event simulation in discrete time (annual periods), implemented in R, which progresses 100,000 individuals through each year of their lives from birth in the year 2000 to death. From age 0 to 18 the model draws observational data from the MCS, with explicit modelling of only a few derived outcomes (mental health, conduct disorder, mortality, health-related quality of life, public costs and a general wellbeing metric). During adulthood, all outcomes are modelled dynamically using explicit networks of stochastic process equations, with separate networks for working age and retirement. Our equations are parameterised using effect estimates from existing studies combined with target outcome levels from up-to-date administrative and survey data. We present our baseline projections and a simple validation check against external data from the British Cohort Study 1970 and Understanding Society survey.
Emerin self-assembly and nucleoskeletal coupling regulate nuclear envelope mechanics against stress
Authors: Fernandez Anthony , Bautista Markville , Wu Liying , Pinaud Fabien 
Published: February 2021

AbstractEmerin is an integral nuclear envelope protein participating in the maintenance of nuclear shape. When mutated or absent, emerin causes X-linked Emery-Dreifuss muscular dystrophy (EDMD). To define how emerin takes parts in molecular scaffolding at the nuclear envelope and helps protect the nucleus against mechanical stress, we established its nanoscale organization using single molecule tracking and super-resolution microscopy. We show that emerin monomers form localized oligomeric nanoclusters stabilized by both lamin A/C and SUN1 at the LINC complex. Interactions of emerin with nuclear actin and BAF additionally modulate its membrane mobility and its ability to oligomerize. In nuclei subjected to mechanical challenges, the mechanotransducing functions of emerin are coupled to changes in its oligomeric state, and the incremental self-assembly of emerin determines nuclear shape adaptation against forces. We also show that the abnormal nuclear envelope deformations induced by EDMD emerin mutants stem from an improper formation of lamin A/C and LINC complex-stabilized emerin oligomers. These findings place emerin at the center of the molecular processes that regulate nuclear shape remodeling in response to mechanical challenges.