bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holographic Interferometry in Automotive Powertrain Component Engineering Analysis
Authors: Forbes James W. , Marchi Mitchell M. , Petniunas Alexander , Wales Raymond R. 
Published: March 2021

Abstract
As increased performance and vehicle system requirements are placed on automotive powertrains more sophisticated methods of engineering analysis are required in their development. Since the containment of noise and vibration is a major design requirement for powertrains, experimental techniques such as laser holographic interferometry are used to tune the dynamic response of system components. This allows the overall system to be optimized from a noise and vibration standpoint as well as from the standpoint of structural integrity. This paper will discuss a variety of examples of how powertrain components have been optimized with the use of holographic methodology.
Hybrid Holographic-Numerical Method for Vibration Studies
Authors: Der Hovanesian Joseph , Hung Y. Y. , Sherman Paul S. 
Published: March 2021

Abstract
This paper presents a hybrid experimental-numerical method for studying dynamic characteristic of vibrating structures. A continuous structure is first lumped into a number of discrete elements and its influence coefficients are measured by holographic interferometry. The eigen values and eigen vectors of the lumped system are then calculated. A major adavantage of the hybrid method is that it is not necessary to know material properties and idealize the boundary conditions, as the measured influcence coefficients will automatically reflect the real boundary and the material behaviors.
Redox-active antibiotics enhance phosphorus bioavailability
Authors: McRose Darcy L. , Newman Dianne K. 
Published: March 2021

Phenazines liberate phosphate
Bacteria secrete a wide range of small molecules with chemical reactivity that offers multiple functions in different contexts. Phenazines are commonly considered to be antibiotics, but they can also participate in environmental redox reactions, especially with iron. McRose and Newman found that phenazines, when added exogenously or made by bacteria in situ, can liberate phosphorous (P) in the form of phosphate from mineral surfaces, and that the production of these molecules is regulated by signaling pathways that respond to P limitation. Strains unable to produce these molecules grew more slowly under P limitation but could be rescued by the addition of exogenous phenazines. The authors hypothesize that reductive dissolution of iron oxides has the benefit of liberating P, and that this could be one mechanism of microbial P acquisition in some environments.

Science
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1033
Sub-Riemannian (2, 3, 5, 6)-Structures
Authors: Sachkov Yu. L. , Sachkova E. F. 
Published: March 2021

Abstract
We describe all Carnot algebras with growth vector (2, 3, 5, 6), their normal forms, an invariant that separates them, and a change of basis that transforms such an algebra into a normal form. For each normal form, Casimir functions and symplectic foliations on the Lie coalgebra are computed. An invariant and normal forms of left-invariant (2, 3, 5, 6)-distributions are described. A classification, up to isometries, of all left-invariant sub-Riemannian structures on (2, 3, 5, 6)-Carnot groups is obtained.
Long-term outcomes of Boston keratoprosthesis type I: the Chinese People’s Liberation Army General Hospital experience
Authors: Wang Li-Qiang , Wu Teng-Yun , Chen Xiao-Niao , Xu Ze-Quan , Yang Min , Xiang Ran , Ma Xiao , Zhang Shan , Huang Yi-Fei 
Published: March 2021

PurposeTo report the long-term outcomes of Boston keratoprosthesis type I (B-KPro type I) implantation in the management of severe ocular surface disorders.MethodsRetrospective case series. Patients who underwent B-KPro type I implantation at the People’s Liberation Army General Hospital were enrolled between March 2011 and September 2019. Data regarding visual acuity (VA), B-KPro type I retention and postoperative complications were recorded and analysed.ResultsA total of 103 eyes of 100 patients who underwent B-KPro type I implantation were included. The main indications were chemical burn (59.2%), ocular trauma (25.2%), herpetic keratitis (11.7%) and autoimmune diseases (3.9%). The percentage of eyes with postoperative VA of 10/200 or better was 82.7% at 6 months, 82.8% at 12 months, 77.9% at 2 years, 72.4% at 3 years, 71.1% at 4 years, 69.4% at 5 years, 58.9% at 6 years, 56.8% at 7 years and 42.9% at 8 years. Preoperatively, 8.7% eyes were diagnosed with new-onset glaucoma. Retroprosthetic membrane formation occurred in 19.4% eye. Corneal melting occurred in 18.4% eyes. Sterile vitritis was diagnosed in 4.9% eyes and infectious endophthalmitis in 2.9% eyes. Retinal detachment occurred in 0.9% eyes.ConclusionsIn a Chinese patient group, B-KPro type I is a viable option for treating severe ocular surface disorders in eyes where conventional keratoplasty would have a poor prognosis, especially in patients with chemical and thermal burns. Improved visual outcomes and high retention rate can be achieved and maintained in most cases.
Use of saliva flow rate measurement in minor salivary glands autotransplantation for treatment of severe dry eye disease
Authors: Su Jia-Zeng , Wang Zhen , Liu Xiao-Jing , Lv Lan , Yu Guang-Yan 
Published: March 2021

AimsTo use minor salivary glands’ flow rate (MSGFR) measurement in minor salivary glands (MSGs) autotransplantation for the treatment of severe dry eye disease (DED).MethodsMSGs autotransplantations were performed in 18 eyes (17 patients) with severe DED. MSGFR were measured before operation. The upper or lower lip with higher MSGFR was selected as the donor site. Buccal mucosa was the back-up in cases labial MSGs showing markedly decreased MSGFRs. Two pieces of salivary lobules with the covering mucosa were harvested and transplanted to the recipient beds prepared in both upper and lower lids.ResultsThe donor sites included lower lip in 12 eyes, upper lip in 5 eyes and buccal mucosa in 1 eye. Postoperative follow-up confirmed viable grafts in all cases. The overall subjective relief rate of DED symptoms was 58.8%, with Schirmer test values increasing from 0 mm to 4 mm (p<0.05). The mean preoperative MSGFR was 1.7 (range: 0.9–3.3) µL/min/cm2. ROC analysis indicated an outstanding discrimination power for preoperative MSGFR to predicate postoperative relief of DED symptoms (area under the curve (AUC)=0.948, p<0.01). The maximum sensitivity (100%) and specificity (72.7%) were reached at a cut-off of 1.785 µL/min/cm2. Patients with preoperative MSGFR >1.785 µL/min/cm2showed greater improvement of Schirmer test values after surgery than those with MSGFR ≤1.785 µL/min/cm2(p<0.05).ConclusionMSGs transplantation proved to be useful for treating severe DED. The amount of postoperative lubrication and the treatment effect were positively correlated with preoperative MSGFR. MSGFR measurement and donor-site selection should be critical steps before the operation.
Ambient air pollution and risk of respiratory infection among adults: evidence from the multiethnic study of atherosclerosis (MESA)
Authors: Kirwa Kipruto , Eckert Carly M , Vedal Sverre , Hajat Anjum , Kaufman Joel D 
Published: March 2021

BackgroundAir pollution may affect the risk of respiratory infection, though research has focused on uncommon infections or infections in children. Whether ambient air pollutants increase the risk of common acute respiratory infections among adults is uncertain, yet this may help understand whether pollutants influence spread of pandemic respiratory infections like COVID-19.ObjectiveTo estimate the association between ambient air pollutant exposures and respiratory infections in adults.MethodsDuring five study examinations over 12 years, 6536 participants in the multiethnic study of atherosclerosis (MESA) reported upper respiratory tract infections, bronchitis, pneumonia or febrile illness in the preceding 2 weeks. Using a validated spatiotemporal model, we estimated residential concentrations of ambient PM2.5, NOxand NO2for the 2–6 weeks (short-term) and year (long-term) prior to each examination.ResultsIn this population aged 44–84 years at baseline, 10%–32% of participants reported a recent respiratory infection, depending on month of examination and study region. PM2.5, NOxand NO2concentrations over the prior 2–6 weeks were associated with increased reporting of recent respiratory infection, with risk ratios (95% CIs) of 1.04 (1.00 to 1.09), 1.15 (1.10 to 1.20) and 1.21 (1.10 to 1.33), respectively, per increase from 25th to 75th percentile in residential pollutant concentration.ConclusionHigher short-term exposure to PM2.5and traffic-related pollutants are associated with increased risk of symptomatic acute respiratory infections among adults. These findings may provide an insight into the epidemiology of COVID-19.
A systematic mixed studies review of patient experiences in the ED
Authors: Bull Claudia , Latimer Sharon , Crilly Julia , Gillespie Brigid M 
Published: March 2021

BackgroundUnderstanding patient experiences is crucial to evaluating care quality in EDs. However, while previous reviews describe the determinants of ED patient experiences (ie, factors that influence patient experiences), few have described actual patient experiences. The aim of this systematic mixed studies review was to describe patient experiences in the ED from the patient’s perspective.MethodsEmbase, Medline, ProQuest Nursing and Allied Health, the Cumulative Index to Nursing and Allied Health Literature and the Cochrane Library electronic databases were searched, with publication dates limited between 1 January 2001 and 16 September 2019. Studies describing adult patient experiences in the ED were included. Studies describing patient satisfaction, proxy-reported experiences or child/adolescent experiences were excluded. The quality of included studies was appraised using the Mixed Methods Appraisal Tool (2018 version). An inductive, convergent qualitative synthesis of the extracted data was undertaken following Thomas and Harden’s (2008) methods.ResultsFifty-four studies were included and of those, only five (9%) studies included a standardised definition of patient experience. Two inter-related themes emerged:Relationships between ED patients and care providers; andSpending time in the ED environment. The first theme included four subthemes regarding respect, communication, caring behaviours and optimising patient confidence. A key finding related to the potential for power imbalances between patients and their care providers. The second theme included two subthemes regarding physical aspects of the ED environment and patients’ waiting experience. Patients attributed more importance to the waiting experience itself rather than the duration they had to wait.ConclusionsPatients in the ED have unique and complex experiences. Greater research is needed to understand the relational and environmental factors that contribute to power imbalances between patients and care providers, how to support more positive waiting experiences, and developing a standardised definition of patient experience in the ED.PROSPERO registration numberCRD42020150154.
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4
Authors: Zhou Tianxing , Liu Jing , Xie Yongjie , Yuan Shuai , Guo Yu , Bai Weiwei , Zhao Kaili , Jiang Wenna , Wang Hongwei , Wang Haotian , Zhao Tiansuo , Huang Chongbiao , Gao Song , Wang Xiuchao , Yang Shengyu , Hao Jihui 
Published: March 2021

Background and aimsThe crosstalk between cancer stem cells (CSCs) and their niche is required for the maintenance of stem cell-like phenotypes of CSCs. Here, we identified E26 transformation-specific homologous factor (EHF) as a key molecule in decreasing the sensitivity of pancreatic cancer (PC) cells to CSCs’ niche stimulus. We also explored a therapeutic strategy to restore the expression of EHF.DesignWe used a LSL-KrasG12D/+mice, LSL-Trp53R172H/+and Pdx1-Cre (KPC) mouse model and samples from patients with PC. Immunostaining, flow cytometry, sphere formation assays, anchorage-independent growth assay, in vivo tumourigenicity, reverse transcription PCR, chromatin immunoprecipitation (ChIP) and luciferase analyses were conducted in this study.ResultsCXCL12 derived from pancreatic stellate cells (PSCs) mediates the crosstalk between PC cells and PSCs to promote PC stemness. Tumorous EHF suppressed CSC stemness by decreasing the sensitivity of PC to CXCL12 stimulus and inhibiting the crosstalk between PC and CSC-supportive niches. Mechanically, EHF suppressed the transcription of the CXCL12 receptor CXCR4. EHF had a cell autonomous role in suppressing cancer stemness by inhibiting the transcription ofSox9,Sox2,Oct4andNanog. Rosiglitazone suppressed PC stemness and inhibited the crosstalk between PC and PSCs by upregulating EHF. Preclinical KPC mouse cohorts demonstrated that rosiglitazone sensitised PDAC to gemcitabine therapy.ConclusionsEHF decreased the sensitivity of PC to the stimulus from PSC-derived CSC-supportive niche by negatively regulating tumorous CXCR4. Rosiglitazone could be used to target PC stem cells and the crosstalk between CSCs and their niche by upregulating EHF.
Defining indicators for drug overdose emergency department visits and hospitalisations in ICD-10-CM coded discharge data
Authors: Vivolo-Kantor Alana , Pasalic Emilia , Liu Stephen , Martinez Pedro D , Gladden Robert Matthew 
Published: March 2021

IntroductionThe drug overdose epidemic has worsened over the past decade; however, efforts have been made to better understand and track nonfatal overdoses using various data sources including emergency department and hospital admission data from billing and discharge files.Methods and findingsThe Centers for Disease Control and Prevention (CDC) has developed surveillance case definition guidance using standardised discharge diagnosis codes for public health practitioners and epidemiologists using lessons learnt from CDC’s funded recipients and the Council for State and Territorial Epidemiologists (CSTE) International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) Drug Poisoning Indicators Workgroup and General Injury ICD-10-CM Workgroup. CDC’s guidance was informed by health departments and CSTE’s workgroups and included several key aspects for assessing drug overdose in emergency department and hospitalisation discharge data. These include: (1) searching all diagnosis fields to identify drug overdose cases; (2) estimating drug overdose incidence using visits for initial encounter but excluding subsequent encounters and sequelae; (3) excluding underdosing and adverse effects from drug overdose incidence indicators; and (4) using codes T36–T50 for overdose surveillance. CDC’s guidance also suggests analysing intent separately for ICD-10-CM coding.ConclusionsCDC’s guidance provides health departments a key tool to better monitor drug overdoses in their community. The implementation and validation of this standardised guidance across all CDC-funded health departments will be key to ensuring consistent and accurate reporting across all entities.
High efficiency and clinical relevance of exome sequencing in the daily practice of neurogenetics
Authors: Thomas Quentin , Vitobello Antonio , Tran Mau-Them Frederic , Duffourd Yannis , Fromont Agnès , Giroud Maurice , Daubail Benoit , Jacquin-Piques Agnès , Hervieu-Begue Marie , Moreau Thibault , Osseby Guy-Victor , Garret Philippine , Nambot Sophie , Delanne Julian , Bruel Ange-Line , Sorlin Arthur , Callier Patrick , Denomme-Pichon Anne-Sophie , Faivre Laurence , Béjot Yannick , Philippe Christophe , Thauvin-Robinet Christel , Moutton Sébastien 
Published: March 2021

ObjectiveTo assess the efficiency and relevance of clinical exome sequencing (cES) as a first-tier or second-tier test for the diagnosis of progressive neurological disorders in the daily practice of Neurology and Genetic Departments.MethodsSixty-seven probands with various progressive neurological disorders (cerebellar ataxias, neuromuscular disorders, spastic paraplegias, movement disorders and individuals with complex phenotypes labelled ‘other’) were recruited over a 4-year period regardless of their age, gender, familial history and clinical framework. Individuals could have had prior genetic tests as long as it was not cES. cES was performed in a proband-only (60/67) or trio (7/67) strategy depending on available samples and was analysed with an in-house pipeline including software for CNV and mitochondrial-DNA variant detection.ResultsIn 29/67 individuals, cES identified clearly pathogenic variants leading to a 43% positive yield. When performed as a first-tier test, cES identified pathogenic variants for 53% of individuals (10/19). Difficult cases were solved including double diagnoses within a kindred or identification of a neurodegeneration with brain iron accumulation in a patient with encephalopathy of suspected mitochondrial origin.ConclusionThis study shows that cES is a powerful tool for the daily practice of neurogenetics offering an efficient (43%) and appropriate approach for clinically and genetically complex and heterogeneous disorders.
Electric field distribution of Ag@CuO and Ag@ZnO core–shell dimer
Authors: Li Guoli , Chen Haixia , Ding Jijun 
Published: March 2021

The effect of shape, material and shell thickness on electric field distribution of both Ag@CuO and Ag@ZnO core–shell dimer is investigated. First, three core–shell structures, including plane@circle, triangle@circle and quadrilateral@circle are designed. The field enhancement advantages of the quadrilateral@circle structures are summarized by analyzing the electric field distribution diagrams. Then the influence of materials on the field enhancement effect of core–shell dimer is discussed. The results show that Ag@CuO structure has better stability, while Ag@ZnO structure have larger electric field enhancement. Finally, the shell thickness is changed from 0.1 nm to 1.5 nm. We found that the X-component electric field of both the Ag@ZnO and Ag@CuO core–shell dimer structure is decreased with the increase in the shell thickness. Also, the X-component electric field of Ag@ZnO core–shell dimer is about five times than that of the Ag@CuO. The increase of electric field indicated that Ag@ZnO core–shell dimer has strong local surface plasma resonance characteristics.
Efficacy of Decitabine plus Anti-PD-1 Camrelizumab in Patients with Hodgkin Lymphoma Who Progressed or Relapsed after PD-1 Blockade Monotherapy
Authors: Wang Chunmeng , Liu Yang , Dong Liang , Li Xiang , Yang Qingming , Brock Malcolm V. , Mei Qian , Liu Jiejie , Chen Meixia , Shi Fengxia , Liu Miao , Nie Jing , Han Weidong 
Published: March 2021

Abstract

Purpose:
Programmed death-1 (PD-1) blockade monotherapy is effective in relapsed/refractory classical Hodgkin lymphoma (cHL), but a subset of patients is recalcitrant to PD-1 inhibitors and only a minority of patients achieves durable remission. Effective treatment regimens for those with relapsed/progressive cHL after single-agent anti-PD-1 are urgently needed. Anti-PD-1 combination with the DNA-demethylating agent decitabine showed positive preliminary results in our test cohort patients who were resistant to anti-PD-1. Here, we assess the efficacy of decitabine plus anti-PD-1 therapy in an expansion cohort and after longer follow-up.

Patients and Methods:
We present the response and progression-free survival rates from patients with relapsed/refractory cHL who relapsed/progressed after prior anti-PD-1 monotherapy, and who received decitabine (10 mg/day, days 1–5) plus the anti-PD-1 camrelizumab (200 mg, day 8), every 3 weeks in a phase II trial (ClinicalTrials.gov: NCT02961101 and NCT03250962).

Results:
Overall, 51 patients (test cohort: 25, expansion cohort: 26) were treated and 50 evaluated for efficacy. The objective response rate was 52% [nine complete responses (CR); 36%] in the test cohort, and 68% (six CRs; 24%) in the expansion cohort. Median progression-free survival with decitabine plus camrelizumab was 20.0 and 21.6 months, respectively, which was significantly longer than that achieved with prior anti-PD-1 monotherapy. Durable response was observed in an estimated 78% of patients who achieved CR at 24 months. After decitabine plus camrelizumab, the ratio increase of circulating peripheral central memory T cells directly correlated with both clinical response and progression-free survival.

Conclusions:
Decitabine plus camrelizumab is associated with high response rates and long-term benefits in patients with relapsed/refractory cHL who failed PD-1 inhibitors.
Qa-1b Modulates Resistance to Anti–PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing
Authors: Zhang Xiao , Sabio Erich , Krishna Chirag , Ma Xiaoxiao , Wang Jingming , Jiang Hui , Havel Jonathan J. , Chan Timothy A. 
Published: March 2021

Abstract

Immune checkpoint blockade (ICB) has improved cancer care, but ICB is only effective in some patients. The molecular mechanisms that influence ICB therapy response are not completely understood. The non-classical MHC class I molecule HLA-E and its mouse ortholog, Qa-1b, present a limited set of peptides in a TAP1-dependent manner to the NKG2A/CD94 heterodimer to transduce an inhibitory signal to natural killer (NK) and CD8+ T cells. However, deficiency of TAP1 allows Qa-1b to present an alternative peptidome to Qa-1b–restricted T-cell receptors of cytotoxic T cells. In this study, we used CRISPR–Cas9 to study the relationship between TAP1, Qa-1b, and response to anti-PD1 therapy. We hypothesized that immunotherapy response in TAP1-deficient tumors would be influenced by Qa-1b. Strikingly, using a syngeneic orthotopic mouse model, we found that although TAP1-deficient tumors were resistant to anti-PD1 treatment, anti-PD1 response was significantly enhanced in tumors lacking both TAP1 and Qa-1b. This increased sensitivity is partially dependent on NK cells. TAP1-deficient tumors were associated with an increase of intratumoral regulatory T cells (Treg) and neutrophils, whereas tumors lacking both TAP1 and Qa-1b exhibited an increased CD8+ T-cell to Treg ratio. These data suggest that direct inhibition of Qa-1b may alter the immune microenvironment to reverse resistance to anti-PD1 therapy, particularly in the context of antigen-processing defects.

Implications:
This study reveals important functional crosstalk between classical TAP-dependent MHC complexes and Qa-1b/HLA-E, particularly in tumors with impaired antigen-processing machinery. This can dramatically influence immunotherapy efficacy.