bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study on the Biological Characteristics of Parthenogenetic and Bisexual Restored Trichogramma pretiosum Lines
Authors: Xiao Zhuangting , Tao Xiaobing , Xu Xin , Zhu Congying , Nian Xiaoge , Han Dongliang , Wang Desen , He Yurong 
Published: September 2021

Abstract
In order to investigate the effect of Wolbachia on fitness of their hosts, the biological characteristics of a primarily parthenogenetic line and a bisexual restored line (obtained by antibiotic treatment) of Trichogramma pretiosum were compared in the laboratory. Results indicated that both the mean longevity and fecundity of parthenogenetic line (14.2 d and 165 eggs/female) were significantly higher than those in bisexual restored line (8.4 d and 124.2 eggs/female). Both lines of T. pretiosum had the highest daily fecundity (23.3 eggs/female for parthenogenetic line and 19.8 eggs/female for bisexual restored line) on the first day during their reproduction period, and their survival rate and daily fecundity decreased gradually with age; however, the survival rate and daily fecundity of the parthenogenetic line were always higher than those of bisexual restored line, during the entire experimental period. There was no significant difference in emergence rate and deformity rate between the two T. pretiosum lines. The life-table parameter results indicated that net reproduction rate (R0) and mean generation time (T) in parthenogenetic line (133 and 16.8) were significantly higher than those in bisexual restored line (61.7 and 15.5); intrinsic rate of natural increase (rm) and finite rate of increase (λ) in parthenogenetic line (0.29 and 1.34) were higher than those in bisexual restored line (0.26 and 1.3). Based on these results, it can be confirmed that the removal of Wolbachia in the parthenogenetic line had an adverse effect on fitness of T. pretiosum.
Dry and Rainy Seasons Significantly Alter the Gut Microbiome Composition and Reveal a KeyEnterococcussp. (Lactobacillales: Enterococcaceae) Core Component inSpodoptera frugiperda(Lepidoptera: Noctuidae) Corn Strain From Northwestern Colombia
Authors: Higuita Palacio Marlon Felipe , Montoya Olga I , Saldamando Clara I , García-Bonilla Erika , Junca Howard , Cadavid-Restrepo Gloria E , Moreno-Herrera Claudia Ximena 
Published: September 2021

AbstractSpodoptera frugiperda is a polyphagous pest of several crops of economic importance. Nowadays, the insect is broadly distributed in America and, recently, in Africa, Asia, and Australia. The species has diverged into corn and rice strains. The role of the gut microbiota in insect physiology is relevant due to its participation in crucial functions. However, knowledge of seasonal variations that alter the gut microbiome in pests is limited. Gut microbiome composition between the dry and rainy seasons was analyzed with cultured and uncultured approaches in S. frugiperda corn strain larvae collected at Northwest Colombia, as seasonal microbiome changes might fluctuate due to environmental changes. On the basis of culture-dependent methods, results show well-defined microbiota with bacterial isolates belonging to Enterococcus, Klebsiella (Enterobacteriales: Enterobacteriaceae), Enterobacter (Enterobacterales: Enterobacteriaceae), and Bacillus (Bacillales: Bacillaceae) genera. The community composition displayed a low bacterial diversity across all samples. The core community detected with uncultured methods was composed of Enterococcus, Erysipelatoclostridium (Erysipelotrichales: Erysipelotrichaceae), Rasltonia (Burkholderiales: Burkholderiaceae), and Rhizobium (Hyphomicrobiales: Rhizobiaceae) genera, and Enterobacteriaceae family members. Significant differences in microbiome diversity were observed between the two seasons. The relative abundance of Erysipelatoclostridium was high in the dry season, while in the phylotype ZOR0006 (Erysipelotrichales: Erysipelotrichaceae) and Tyzzerella (Lachnospirales: Lachnospiraceae) genus, the relative abundance was high in the rainy season. The overall low gut bacterial diversity observed in the S. frugiperda corn strain suggests a strong presence of antagonist activity as a selection factor possibly arising from the host, the dominant bacterial types, or the material ingested. Targeting the stability and predominance of this core microbiome could be an additional alternative to pest control strategies, particularly in this moth.
Application of Deep Learning to Community-Science-Based Mosquito Monitoring and Detection of Novel Species
Authors: Khalighifar Ali , Jiménez-García Daniel , Campbell Lindsay P , Ahadji-Dabla Koffi Mensah , Aboagye-Antwi Fred , Ibarra-Juárez Luis Arturo , Peterson A Townsend 
Published: September 2021

AbstractMosquito-borne diseases account for human morbidity and mortality worldwide, caused by the parasites (e.g., malaria) or viruses (e.g., dengue, Zika) transmitted through bites of infected female mosquitoes. Globally, billions of people are at risk of infection, imposing significant economic and public health burdens. As such, efficient methods to monitor mosquito populations and prevent the spread of these diseases are at a premium. One proposed technique is to apply acoustic monitoring to the challenge of identifying wingbeats of individual mosquitoes. Although researchers have successfully used wingbeats to survey mosquito populations, implementation of these techniques in areas most affected by mosquito-borne diseases remains challenging. Here, methods utilizing easily accessible equipment and encouraging community-scientist participation are more likely to provide sufficient monitoring. We present a practical, community-science-based method of monitoring mosquito populations using smartphones. We applied deep-learning algorithms (TensorFlow Inception v3) to spectrogram images generated from smartphone recordings associated with six mosquito species to develop a multiclass mosquito identification system, and flag potential invasive vectors not present in our sound reference library. Though TensorFlow did not flag potential invasive species with high accuracy, it was able to identify species present in the reference library at an 85% correct identification rate, an identification rate markedly higher than similar studies employing expensive recording devices. Given that we used smartphone recordings with limited sample sizes, these results are promising. With further optimization, we propose this novel technique as a way to accurately and efficiently monitor mosquito populations in areas where doing so is most critical.
Food Allergy-Related Bullying Among Children and Adolescents
Authors: Cooke Frances , Ramos Ashley , Herbert Linda 
Published: September 2021

Abstract

Objective
Food allergy (FA) management requires youth to avoid allergens and carry emergency medication which can impact participation in social activities. Previous research indicates that some youth experience FA-related bullying, but many studies are limited by single-item assessment methods and a narrow definition of bullying. This study describes FA-related bullying among a diverse cohort of youth with FA and evaluates parent–child disagreement and bullying assessment methods.

Methods
Youth ages 9–15 years (n = 121) diagnosed with an IgE-mediated FA and their primary caregivers were recruited from pediatric FA clinics to complete surveys about their FA-related bullying experiences. Descriptive statistics were conducted to assess overall FA-related bullying and McNemar tests were utilized to assess disagreement among parent–child report and between multi-item and single-item assessment methods.

Results
Seventeen percent and 31% of youth reported FA-related bullying on single-item and multi-item assessments, respectively. Twelve percent of parents reported their child had experienced FA-related bullying. Youth reported overt physical (51%), overt non-physical (66%), and relational FA-related bullying (20%). FA-related bullying was most common among classmates. Assessment method significantly affected the rates of FA-related bullying reported by youth, and parents and youth only agreed on FA-bullying experiences when assessed via the single-item measure.

Conclusions
A subset of a diverse sample of youth with FA reported FA-related bullying. Clinicians should use multi-item assessment methods and ask both parents and children about their experiences to fully capture the experiences of families managing FA. School policies that facilitate FA safety and social inclusion should be promoted.

Clinical Trial Registration
N/A.
The Omid Litigation: Should Courts Hear Oral Evidence When Determining the Proportionality of Section 2(1) of the Suicide Act 1961?
Authors: Papadopoulou Nataly , Hobson Clark 
Published: September 2021

Abstract
This commentary reviews Mr Omid T’s legal challenge for a declaration of incompatibility under section 4 of the Human Rights Act 1998. Omid argued that section 2(1) of the Suicide Act 1961 is incompatible with his Articles 2 and 8 rights under the European Convention on Human Rights (ECHR). The Omid litigation considers whether it is appropriate and necessary that courts should hear primary oral evidence with cross-examination in determining the ethical, moral, and social policy issues that underlie the assessment of whether the Suicide Act is a disproportionate restriction on Omid’s rights. The question of what type of evidence would need to be available to courts to determine section 2(1)’s proportionality is an important question left unresolved by Nicklinson v Ministry of Justice. The Omid litigation concludes it is inappropriate and unnecessary that courts should hear oral evidence and permit cross-examination in determining section 2(1)’s proportionality. The commentary analyses the reasoning in the Omid litigation regarding why it is inappropriate to hear oral evidence with cross-examination in determining section 2(1)’s proportionality. The commentary then argues a persuasive case can be made for the appropriateness of oral evidence and cross-examination in assisted suicide proportionality cases.
Segregational Drift Constrains the Evolutionary Rate of Prokaryotic Plasmids
Authors: Garoña Ana , Hülter Nils F , Romero Picazo Devani , Dagan Tal 
Published: September 2021

Abstract
Plasmids are extrachromosomal genetic elements in prokaryotes that have been recognized as important drivers of microbial ecology and evolution. Plasmids are found in multiple copies inside their host cell where independent emergence of mutations may lead to intracellular genetic heterogeneity. The intracellular plasmid diversity is thus subject to changes upon cell division. However, the effect of plasmid segregation on plasmid evolution remains understudied. Here, we show that genetic drift during cell division—segregational drift—leads to the rapid extinction of novel plasmid alleles. We established a novel experimental approach to control plasmid allele frequency at the levels of a single cell and the whole population. Following the dynamics of plasmid alleles in an evolution experiment, we find that the mode of plasmid inheritance—random or clustered—is an important determinant of plasmid allele dynamics. Phylogenetic reconstruction of our model plasmid in clinical isolates furthermore reveals a slow evolutionary rate of plasmid-encoded genes in comparison to chromosomal genes. Our study provides empirical evidence that genetic drift in plasmid evolution occurs at multiple levels: the host cell and the population of hosts. Segregational drift has implications for the evolutionary rate heterogeneity of extrachromosomal genetic elements.
DDInter: an online drug–drug interaction database towards improving clinical decision-making and patient safety
Authors: Xiong Guoli , Yang Zhijiang , Yi Jiacai , Wang Ningning , Wang Lei , Zhu Huimin , Wu Chengkun , Lu Aiping , Chen Xiang , Liu Shao , Hou Tingjun , Cao Dongsheng 
Published: September 2021

Abstract
Drug-drug interaction (DDI) can trigger many adverse effects in patients and has emerged as a threat to medicine and public health. Despite the continuous information accumulation of clinically significant DDIs, there are few open-access knowledge systems dedicated to the curation of DDI associations. To facilitate the clinicians to screen for dangerous drug combinations and improve health systems, we present DDInter, a curated DDI database with comprehensive data, practical medication guidance, intuitive function interface, and powerful visualization to the scientific community. Currently, DDInter contains about 0.24M DDI associations connecting 1833 approved drugs (1972 entities). Each drug is annotated with basic chemical and pharmacological information and its interaction network. For DDI associations, abundant and professional annotations are provided, including severity, mechanism description, strategies for managing potential side effects, alternative medications, etc. The drug entities and interaction entities are efficiently cross-linked. In addition to basic query and browsing, the prescription checking function is developed to facilitate clinicians to decide whether drugs combinations can be used safely. It can also be used for informatics-based DDI investigation and evaluation of other prediction frameworks. We hope that DDInter will prove useful in improving clinical decision-making and patient safety. DDInter is freely available, without registration, at http://ddinter.scbdd.com/.
SYST-04. TRAM-01: A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY
Authors: Perreault Sébastien , Larouche Valérie , Tabori Uri , Hawkins Cynthia , Lippé Sarah , Ellezam Benjamin , Decarie Jean-Claude , Ospina Luis H , Theoret Yves , Desjardins Leandra , Metras Marie-Élaine , Sultan Serge , Cantin Edith , Routhier Marie-Eve , Caru Maxime , Vairy Stephanie , Legault Genevieve , Bouffet Eric , Lafay-Cousin Lucie , Hukin Juliette , Erker Craig , Jabado Nada 
Published: September 2021

Abstract

BACKGROUND
Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway.

METHODS
This ongoing multicenter phase II trial includes three progressing/refractory PLGG groups: NF1 patients, KIAA1549-BRAF fusion patients and patients with other activation of the MAPK/ERK pathway (excluding V600E). The primary objective was to evaluate the overall response rate based on RANO criteria after daily oral trametinib administration for 18 cycles, lasting 28 days each. Secondary objectives include the assessment of progression-free survival, tolerability of trametinib, serum levels of trametinib and quality of life evaluation during treatment.

RESULTS
As of February 12 2021, 50 patients have been enrolled (NF1: n=10; KIAA1549-BRAF fusion: n=31; other: n=9 including 5 patients with FGFR1 alterations). Median age is 8.8 years (range 2.4-25.5). Median follow-up is 17.5 months (range 4.7-28.5). Forty-three patients are evaluable. The overall response includes: 4 partial response (PR) (9%), 18 minor response (MR) (42%), 17 stable disease (40%), 4 progressive disease (9%). Median time to response is 5.5 months (range 2.4-13.8). Median duration of response is 6.1 months (range 0.6-26.5). Progression free survival at 12 months is 79.9% (95% CI 68.5-93.6%) and median progression free survival has not yet been reached. Treatment was discontinued for 30 patients: 16 after completing 18 cycles as planned, 5 for progressive disease, 5 for adverse events, 4 for other reasons. A total of 8 patients progressed after discontinuation of treatment including 6 patients (37.5%) that completed 18 cycles. Five of these patients had achieved minor response prior to discontinuation.

CONCLUSION
Trametinib is a potentially effective targeted therapy for patients with recurrent/refractory PLGG. Treatment was overall well tolerated. This ongoing trial will continue to gather data on response rate, duration of response and safety of trametinib for PLGG.
On the Moral Impact Theory of Law
Authors: Monti Ezequiel H 
Published: September 2021

Abstract
Mark Greenberg argues that legal obligations are those moral obligations created by the actions of legal institutions in the legally proper way (Moral Impact Theory of Law, MITL). Here I defend three main claims. First, I argue that, although very often misunderstood, Joseph Raz is also a defender of MITL. Secondly, I argue that while both Greenberg and Raz are committed to MITL, they disagree about the conditions under which a moral obligation can be said to be created in the legally proper way. Finally, I argue that Raz’s variant of MITL is better than Greenberg’s. It rests on a more plausible account of authority and it avoids one of the crucial defects threatening Greenberg’s view, namely, its overinclusiveness.
Sexuality in Emerging Adulthood
Authors: Olmstead Spencer B. , Anders Kristin M. 
Published: September 2021

Abstract
Scientific theory is essential to research on sexuality and sexual experiences in emerging adulthood. Theory serves a number of important functions for research, including prediction and explanation. Research has often utilized theory to help enhance what is known about sexuality among those in the developmental period of emerging adulthood. This chapter offers a primer on theories that have been used regularly when studying sex and relationships using emerging adult samples, including life course development theory, symbolic interactionism, social exchange theory, and the theory of sexual possible selves. Following discussion of these theories and their role in guiding research and explaining findings on sex and sexuality, this chapter offers theoretical directions to enhance the rigor of the use of theory in future research on sexual experiences among emerging adults.
Emerging Adult Sexual Behavior
Authors: Vasilenko Sara A. 
Published: September 2021

Abstract
By emerging adulthood, the majority of individuals have engaged in some types of sexual behavior. However, during this period there is considerable variability and change in the prevalence of recent sexual behaviors and their relationship contexts. This chapter reviews the literature on the prevalence of multiple sexual behaviors, focusing on data from nationally representative studies where possible. Findings suggest that most emerging adults engage in behaviors such as kissing, oral sex, and vaginal intercourse during emerging adulthood, with peak prevalence of these behaviors in the late twenties or early thirties. Other behaviors, such as partnered masturbation, anal sex, and kink behaviors are also practiced by a sizeable minority of individuals. Although many individuals engage in casual sex during emerging adulthood, most instances of sexual behavior occur in relationships. Differences in sexual behavior across several subgroups are discussed, with a particular focus on gender and sexual orientation.
Brief Report
Authors: Palmer-Webb Carlie , Nelson Larry J , Millett Mallory A 
Published: September 2021

Abstract
Scholars have briefly examined the substantial impact of shyness on sexual attitudes and behaviors in emerging adulthood. However, shyness is only one form of social withdrawal that has been identified. Building on previous research, the purpose of this study was to examine the associations between three distinct forms of social withdrawal—shyness, avoidance, and unsociability—and the sexual attitudes and behaviors of emerging adults. Participants included 792 undergraduate and graduate students from throughout the United States gathered as a part of Project READY. Results revealed that each form of social withdrawal was uniquely associated with sexual attitudes and behaviors, with shyness leading the subtypes in its reach of influence across outcomes and gender.
Brief Report
Authors: Kaufman-Parks Angela M. , Longmore Monica A. , Manning Wendy D , Giordano Peggy C. 
Published: September 2021

Abstract
Much prior research acknowledges that peers influence adolescents’ sexual behaviors. Yet few studies have explored whether and how peers influence sexual decision making among emerging adults, especially among those in committed intimate partnerships, while also accounting for dynamics specific to the intimate relationship and respondents’ sociodemographic characteristics. Drawing on longitudinal data from the Toledo Adolescent Relationships Study, this report examined multiple aspects of peer influence on three different sexual behaviors among emerging adults: sexual non-exclusivity, number of casual sex partners, and lifetime number of sex partners. It was found that having more sexually liberal peers and peers who engaged in criminal activity significantly influenced emerging adults’ self-reported numbers of casual and lifetime sex partners, as well as the frequency of engagement in sexually non-exclusive behaviors among those in committed dating, cohabiting, and marital partnerships. This report discusses potential theoretical mechanisms linking these relationships and provides suggestions for future research.
Sexual Health in Emerging Adulthood
Authors: Joppa Meredith , Cantor Nicole , Doremus Corey 
Published: September 2021

Abstract
Sexual health in emerging adulthood encompasses a wide spectrum of medical and mental health functioning and associated behaviors. This chapter addresses aspects of physical sexual health that are of concern to emerging adults, including prevalence rates, determinants, and consequences of sexually transmitted infections, including HIV, and unintended pregnancy among emerging adults. The chapter also discusses sexual dysfunction and its treatment. Whenever possible, the chapter highlights differences in prevalence, risk, and protective factors related to aspects of human diversity, guided by an intersectional approach based on the ADDRESSING framework. Both protective and risky sexual health behaviors and decision making about sexual behavior are discussed, with a focus on the role of substance use in sexual risk taking. The chapter concludes with implications for future research, particularly in the area of prevention.
Sexual Well-Being in Emerging Adulthood
Authors: Espinosa-Hernández Graciela , Vasilenko Sara A 
Published: September 2021

Abstract
This chapter reviews the literature on sexual well-being, defined as the positive cognitive and emotional evaluations of one’s sexuality. Components include sexual self-esteem, sexual self-efficacy, sexual self-reflection, sexual satisfaction and pleasure, and positive emotional response. Most researchers have examined condom use self-efficacy and sexual satisfaction. For some constructs, men, compared to women, report better sexual well-being (e.g., condom use self-efficacy and orgasm). Little is known about how sexual well-being changes in emerging adulthood, but it is known that constructs vary by sexual and romantic experience. Emerging adults who are more sexually experienced and engage in behaviors in the context of romantic relationships report better sexual well-being. Many sexual well-being constructs are also linked with less risky sexual behavior and better psychological adjustment (e.g., self-esteem and identity development). Future recommendations include measurement research to better understand overlapping constructs, examining diverse samples, and more longitudinal research.