bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of system and product certification as quality infrastructure in Indonesia
Authors: Isharyadi Febrian , Kristiningrum E. 
Published: March 2021

Abstract
Quality is a universal standard that is expected by consumers of a product or service used. Consumers in general cannot individually assess this quality, with the help of an independent third party it can be done. The certification body is one element in the quality infrastructure that plays a role in providing quality assurance of products and services according to applicable standards. There are various certification bodies in Indonesia both for system and product certification, the kinds additionally range in accordance to the scope of certification. However, it is not yet known generally the condition of the system and product certification in Indonesia. The aim of this study is to conduct profiling and analyse the condition of the system and product certification in Indonesia using a comprehensive tool in order to assess part of the quality of a country's infrastructure. The results showed that there were several elements that were fulfilled, especially in terms of legality and national recognition. However, some elements still need improvement so that the certification body can do its part to ensure the quality of products and services.
Enhancement stability and color fastness of natural dye: A review
Authors: Harsito Catur , Prabowo Aditya Rio , Prasetyo Singgih Dwi , Arifin Zainal 
Published: March 2021

Abstract
Consumer awareness of the adverse biological effects of synthetic dyes makes the demand for commercial foods and drinks with natural ingredients increase. The use of natural dyes is increasing and is in demand by consumers in the industrial world. Natural dyes have been used in several sectors such as food, clothing, arts, coatings, and energy. The low stability and brightness of the natural red color are affected by exposure to light, temperature, pH and etc. The co-pigmentation process makes the stability and brightness of natural dyes. The copigmentation method is known that there are two type, liquid and powder. In addition, the combination of copigmentation additives and the correct configuration of the spray dryer process can increase quality color fastness and stability.
Adjectives as roots of nominal groups: the big mess construction in dependency grammar
Authors: Osborne Timothy 
Published: March 2021

AbstractThe so-called ‘Big Mess Construction’ (BMC) frustrates standard assumptions about the structure of nominal groups. The normal position of an attributive adjective is after the determiner and before the noun, but in the BMC, the adjective precedes the determiner, e.g.that strange a sound,so big a scandal,too lame an excuse. Previous accounts of the BMC are couched in ‘Phrase Structure Grammar’ (PSG) and view the noun or the determiner (or the prepositionof) as the root/head of the BMC phrase. In contrast, the current approach, which is couched in a ‘Dependency Grammar’ (DG) model, argues that the adjective is in fact the root/head of the phrase. A number of insights point to the adjective as the root/head, the most important of which is the optional appearance of the prepositionof, e.g.that strange of a sound,so big of a scandal,too lame of an excuse.
Stability analysis for Selkov-Schnakenberg reaction-diffusion system
Authors: Al Noufaey K. S. 
Published: March 2021

Abstract
This study provides semi-analytical solutions to the Selkov-Schnakenberg reaction-diffusion system. The Galerkin method is applied to approximate the system of partial differential equations by a system of ordinary differential equations. The steady states of the system and the limit cycle solutions are delineated using bifurcation diagram analysis. The influence of the diffusion coefficients as they change, on the system stability is examined. Near the Hopf bifurcation point, the asymptotic analysis is developed for the oscillatory solution. The semi-analytical model solutions agree accurately with the numerical results.
miR-377 inhibition enhances the survival of trophoblast cells via upregulation of FNDC5 in gestational diabetes mellitus
Authors: Hua Zhaozhao , Li Dana , Wu Anqin , Cao Ting , Luo Shi 
Published: March 2021

Abstract
Gestational diabetes mellitus (GDM) is a metabolic dysregulation closely related to both obesity and type 2 diabetes; however, the molecular mechanism underlying GDM is still unclear. The purpose of this study was to investigate the effects of microRNA-377 (miR-377-3p) and fibronectin type III domain containing 5 (FNDC5) in regulating the cell growth of trophoblasts under high glucose (HG) conditions during the development of GDM. Serum miR-377-3p was upregulated and positively correlated with fasting blood glucose level in GDM patients. miR-377-3p downregulation increased the cell vitality and suppressed the cell apoptosis of HG-treated HTR-8/SVneo and BeWo cells. Using TargetScan prediction, luciferase assay, and western blot, it was found that miR-377-3p could target FNDC5 and suppress its expression. However, FNDC5 downregulation abolished the effect of miR-377-3p inhibitor in HTR-8/SVneo cells. Together, miR-377 is a potential target for GDM biomarker, which promotes cell growth and suppresses cell apoptosis, partly through the upregulation of FNDC5.
Hippocampal toxicity of metal base nanoparticles. Is there a relationship between nanoparticles and psychiatric disorders?
Authors: Mohammadipour Abbas , Abudayyak Mahmoud 
Published: March 2021

Abstract
Metal base nanoparticles are widely produced all over the world and used in many fields and products such as medicine, electronics, cosmetics, paints, ceramics, toys, kitchen utensils and toothpastes. They are able to enter the body through digestive, respiratory, and alimentary systems. These nanoparticles can also cross the blood brain barrier, enter the brain and aggregate in the hippocampus. After entering the hippocampus, they induce oxidative stress, neuro-inflammation, mitochondrial dysfunction, and gene expression alteration in hippocampal cells, which finally lead to neuronal apoptosis. Metal base nanoparticles can also affect hippocampal neurogenesis and synaptic plasticity that both of them play crucial role in memory and learning. On the one hand, hippocampal cells are severely vulnerable due to their high metabolic activity, and on the other hand, metal base nanoparticles have high potential to damage hippocampus through variety of mechanisms and affect its functions. This review discusses, in detail, nanoparticles’ detrimental effects on the hippocampus in cellular, molecular and functional levels to reveal that according to the present information, which types of nanoparticles have more potential to induce hippocampal toxicity and psychiatric disorders and which types should be more evaluated in the future studies.
Crypto-assets portfolio selection and optimization: a COGARCH-Rvine approach
Authors: Mba Jules Clement , Mwambetania Mwambi Sutene 
Published: March 2021

Abstract
Blockchain is a new technology slowly integrating our economy with crytocurrencies such as Bitcoin and many more applications. Bitcoin and other version of it (known as Altcoins) are traded everyday at various cryptocurrency exchanges and have drawn the interest of many investors. These new type of assets are characterised by wild swings in prices and this can lead to great profit as well as large losses. To respond to these dynamics, crypto investors need adequate tools to guide them through their choice of optimal portfolio selection. This paper presents a portfolio selection based on COGARCH and regular vine copula which are able to capture features such as abrupt jumps in prices, heavy-tailed distribution and dependence structure respectively, with the optimal portfolio achieved through the stochastic heuristic algorithm differential evolution known for its global search solution ability. This method shows great performance as compared with other available models and can achieve up to 50% of total returns in some periods of optimization.
Algorithmenbasierte Fabrikplanung
Authors: Kreß Antonio , Mittenzwei Björn , Knöß Martin , Metternich Joachim 
Published: March 2021

Abstract
Rechnergestützte Optimierungsverfahren unterstützen Entscheidungen der innerbetrieblichen Layoutplanung. Beim Facility Layout Problem (FLP) wird die bestmögliche Position von Maschinen und Anlagen in einem Fabrikgelände bestimmt. In diesem Beitrag wird gezeigt, wie die Lösung des FLP dazu beitragen kann, das Fabriklayout der SMC Deutschland GmbH für eine geplante Erweiterung zu optimieren. Zum Einsatz kamen dabei genetische Algorithmen. Die Lösung des FLP wurde mit dem aktuellen Planungsstand im Unternehmen verglichen. Dabei wurde festgestellt, dass bei Anwendung des FLP bis zu 14 Prozent bessere Zielfunktionswerte erreicht werden.
Assessing Brazilian food establishments' hygienic handling of leafy vegetables and their microbiological quality
Authors: Ferreira M.R. , Santos T.S. , Maffei D.F. 
Published: March 2021

AbstractIn this study, the hygienic handling of leafy vegetables was evaluated in ten selected food establishments located in south-eastern Brazil. A 14-question survey was applied in these establishments, addressing the origin of the vegetables, washing procedures, and temperature conditions during storage and exposure. In addition, 30 samples of leafy vegetables were collected and submitted to the enumeration of total coliforms, coliforms at 45 °C and tested for Salmonella. Based on the responses to the survey, the establishments could be clustered into three groups. Group 1 included four establishments, where the vegetables originated from farms exclusively and were displayed to consumers at room temperature, and where most of the food handlers had participated in courses on good handling practices. Group 2 included two establishments that performed a centrifugation step and where vegetables were not available to consumers in a self-service. Finally, group 3 included four establishments, where vegetables originated from suppliers exclusively, were stored under refrigeration, and displayed to consumers on refrigerated tables. The mean count of total coliforms was 2.5 ± 0.7 log MPN/g, while coliforms at 45 °C were detected in only one sample (0.9 log MPN/g). Salmonella was not found in any sample. Microbiological results obtained for leafy vegetables from establishments clustered in the three groups did not differ significantly. These data contribute to a better understanding of the hygienic handling of leafy vegetables in the surveyed Brazilian food establishments.
Occurrence and significance of smectite in the Pliensbachian (Lower Jurassic) at Lókút (Bakony Mts., Hungary)
Authors: Leskó Máté Zsigmond , Papp Richárd Zoltán , Kristály Ferenc , Pálfy József , Zajzon Norbert 
Published: March 2021

AbstractAlthough the Mesozoic rocks of the Transdanubian Range have been the subject of a multitude of different studies, mineralogical research is largely underrepresented. The clay mineralogy of Lower Jurassic (especially the Pliensbachian and Toarcian) strata was broadly investigated earlier; however, systematic high-resolution clay mineralogical studies remain scarce. Here we present a mineralogical study focusing on the Upper Pliensbachian strata of the Lókút-Hosszúárok section, located near the Eplény Manganese Ore Field. We identified dioctahedral smectite, randomly interstratified illite/smectite, illite as 10 Å phyllosilicate, quartz and cristobalite. Based on our new results we propose that the smectite was formed by aging of Mg or Fe hydroxide-silica precipitates. The smectite and cristobalite were presumably formed from the siliceous tests of radiolarians, whose abundance was controlled by a local upwelling system. The occurrence of Pliensbachian smectite in the Lókút outcrop shows similarities with the Úrkút smectites known from both Pliensbachian and Toarcian strata, which implies that similar processes controlled the sedimentation during the Pliensbachian as well as during the black (gray) shale-hosted ore accumulation in the Eplény and Úrkút basins.
Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes
Authors: Yang Jingping , Zhang Difei , Motojima Masaru , Kume Tsutomu , Hou Qing , Pan Yu , Duan Aiping , Zhang Mingchao , Jiang Song , Hou Jinhua , Shi Jingsong , Qin Zhaohui , Liu Zhihong 
Published: March 2021

Significance Statement
Cell fate is determined by unique transcriptional programs at different life stages. The podocyte is a critical cell type for renal function. Transcription factors like FOXC1/2 have been reported to be indispensable for podocyte maintenance, but their roles in transcription and the genome-wide regulatory network have been rarely studied. Here, FOXC1/2 are discovered to play meaningful roles in core regulatory circuits as they associate with superenhancers in glomeruli. The integration of transcriptome and cistrome analysis dissected the regulatory mechanism of FOXC1/2 to reinforce the differentiation of mature podocytes. The results reveal podocytes use an intrinsic transcriptional regulation to maintain cell identity. The study also provides a glomerulus-specific, chromatin-feature resource for further understanding podocytopathy.

Background
Transcriptional programs control cell fate, and identifying their components is critical for understanding diseases caused by cell lesion, such as podocytopathy. Although many transcription factors (TFs) are necessary for cell-state maintenance in glomeruli, their roles in transcriptional regulation are not well understood.

Methods
The distribution of H3K27ac histones in human glomerulus cells was analyzed to identify superenhancer-associated TFs, and ChIP-seq and transcriptomics were performed to elucidate the regulatory roles of the TFs. Transgenic animal models of disease were further investigated to confirm the roles of specific TFs in podocyte maintenance.

Results
Superenhancer distribution revealed a group of potential TFs in core regulatory circuits in human glomerulus cells, including FOXC1/2, WT1, and LMX1B. Integration of transcriptome and cistrome data of FOXC1/2 in mice resolved transcriptional regulation in podocyte maintenance. FOXC1/2 regulated differentiation-associated transcription in mature podocytes. In both humans and animal models, mature podocyte injury was accompanied by deregulation of FOXC1/2 expression, and FOXC1/2 overexpression could protect podocytes in zebrafish.

Conclusions
FOXC1/2 maintain podocyte differentiation through transcriptional stabilization. The genome-wide chromatin resources support further investigation of TFs’ regulatory roles in glomeruli transcription programs.
COMPORTAMENTO GERMINATIVO DE Baccharis platypoda DC. EM AMBIENTES DE FORMAíâ?¡íâ?¢ES SAVíâ??NICAS.
Authors: De Moura Cristiane Coelho , Fonseca Darliana da Costa , Machado Evandro Luiz Mendonça 
Published: March 2021

A germinação pode determinar a distribuição das espécies nas comunidades vegetais e permite compreender os fatores limitantes para o seu estabelecimento, sobrevivência e regeneração. Deste modo, objetivou-se analisar o comportamento germinativo de sementes de Baccharis platypoda de áreas savânicas em anos consecutivos. Foram coletadas amostras de sementes em três áreas, sendo montado o teste em delineamento inteiramente casualizado fatorial 3x2, com cinco repetições e 100 sementes por repetição. As amostras foram colocadas para germinar a 26 úC com fotoperí­odo de 12 horas e mantidas em câmara B.O.D. por 30 dias. Foi avaliado o percentual de germinação (G), tempo médio de germinação, IVE e ANOVA. Houve diferenças significativas entre as áreas e IVE para a porcentagem de germinação, não havendo diferenças entre os anos de coleta. Este comportamento pode ser resultado das variações ambientais existentes nas áreas de estudo que afetam a qualidade das sementes e as taxas degerminação.
MORFO-ANATOMIA DO XILOPíâ??DIO DO GEOARBUSTO Galianthe grandifolia E.L. Cabral (RUBIACEAE) E A OCORRíÅ NCIA INCOMUM DE COLÉTERES SUBTERRíâ??NEOS.
Authors: Vilhalva Divina Aparecida Anunciação , Cortelazzo Ângelo Luiz , Gomes Sueli Maria 
Published: March 2021

Espécies de Galianthe (Rubiaceae) são descritas como tendo xilopódio, mas ainda não há estudos anatômicos que corroborem isto. O objetivo deste trabalho é caracterizar o eixo subterrâneo principal de Galianthe grandifolia E.L. Cabral. Para isto, as amostras foram retiradas do solo e examinadas sob microscopia ótica e eletrônica de varredura. Comprovou-se que a estrutura analisada é um xilopódio, de natureza mista caulinar e radicular, apresentando várias gemas protegidas por catafilos com glândulas axilares e adaxiais, cuja análise estrutural e histoquí­mica evidenciou que são coléteres. Coléteres aéreos são comuns em espécies de Rubiaceae e outras famí­lias de angiospermas, mas ao que se saiba este é o primeiro relato da ocorrência destas glândulas em órgãos subterrâneos vegetais. O papel ecológico dos coléteres subterrâneos é discutido, assim como o uso do conceito de geoarbusto para G. grandifolia e outras plantas do Cerrado. Os resultados subsidiam a taxonomia do gênero.
GERMINAíâ?¡ÃO DE SEMENTES DE Vellozia ramosissima L. B. Sm. (VELLOZIACEAE) EM RESPOSTA íâ?¬ DIFERENTES TEMPERATURAS
Authors: Costa Thaí­s Ribeiro , De Moura Cristiane Coelho , Batista Denise de Souza , Fonseca Darliana da Costa , Mendonça Machado Evando Luiz 
Published: March 2021

Devido escassez de estudos acerca do gênero Vellozia e sua importância ecológica nos Complexos Rupestres da Cadeia do Espinhaço, este trabalho teve como objetivo avaliar a germinação das sementes de canela-de-ema (Vellozia ramosissima L.B.Sm.), submetidas s temperaturas constantes de, 20í°C, 30í°C, 40í°C e 50í°C. O delineamento experimental adotado foi inteiramente casualizado, com quatro repetições, sendo cinquenta amostras por repetição. A contagem da germinação foi realizada durante 30 dias. Os parâmetros avaliados foram a porcentagem, o í­ndice de velocidade e o tempo médio de germinação. A germinação foi nula a 50í°C, e a faixa de germinabilidade ocorreu nas temperaturas de 20, 30 e 40í°C. A ocorrência de germinação da espécie em uma maior amplitude de temperatura sugere a capacidade de colonização numa maior diversidade de hábitats, indicando adaptação da mesma a ambientes expostos ao sol e substratos sombreados, como fendas de rochas.
LEVANTAMENTO DE AGENTES ZOONíâ??TICOS ENCONTRADOS EM PEQUENOS MARSUPIAIS DA AMÉRICA DO SUL
Authors: Povill Cintia , Lazar Ana , Bonvicino Cibele Rodrigues 
Published: March 2021

Zoonoses são doenças que são transmitidas de animais vertebrados para o homem e também do homem para os animais, principalmente quando seu ciclo ecológico é alterado, seja por intervenção natural ou pela intervenção humana. Incluem doenças emergentes e reemergentes distribuí­das mundialmente e de preocupação para a saúde pública, pois causam vários prejuí­zos e mortes na população humana. Estudos revelam que as zoonoses estão ligadas a várias espécies de mamí­feros, incluindo os marsupiais, que atuam como hospedeiros de algumas destas doenças zoonóticas. Apesar da maioria dos estudos se concentrarem em marsupiais didelfí­deos de porte maior, identificamos várias espécies de pequenos marsupiais dos gêneros Monodelphis, Marmosa (Marmosa), Marmosa (Micoureus), Gracilinanus e Thylamys como hospedeiras de agentes zoonóticos causadores de doenças, como toxoplasmose, leishmaniose, tripanossomí­ase, verminoses, coccidiose, arboviroses, microsporidiose, peste negra e fasciolí­ase, na América do Sul, e no Brasil. Algumas destas informações sobre marsupiais como hospedeiros não podem ser recuperadas em função da falta de espécimes testemunhos, aliado s mudanças taxonômicas ocorridas dentro do grupo.
Borboletas (Lepidoptera: Papilionoidea) coletadas em uma área de cerrado próximo a Pirenópolis, Goiás, Brasil
Authors: Ribeiro Millena Castro , Sampaio Roberto Cavalcanti 
Published: March 2021

Na Lista Nacional de Espécies Ameaçadas de Extinção, as borboletas representam 42% dos invertebrados ameaçados. Portanto, os principais objetivos desse projeto foram: (1) registrar a diversidade de borboletas encontradas em uma área de Cerrado; (2) demonstrar a importância da preservação dos fragmentos de Cerrado existentes nesta região; (3) incentivar que mais estudos de diversidade entomológica sejam realizados para melhorar o conhecimento da entomofauna do Cerrado. Nesta nota são listadas 17 espécies que foram identificadas através de coletas realizadas pelo Jardim Botânico de Brasí­lia com intuito de fomentar sua coleção entomológica.Palavras-chave: Brasil Central, Campo rupestre, Entomofauna. Butterflies (Lepidoptera: Papilionoidea) collected in a Cerrado area near Pirenópolis, Goiás, Brazil In order to improve the entomological collection of the Jardim Botânico de Brasí­lia and our knowledge of the order Lepidoptera in the Cerrado biome, an inventory of butterflies was performed in the Zen Horyu-Zan Eisho-Ji Monastery near Pirenópolis, Goiás, Brazil. Three collecting expeditions were done and 17 species of butterflies were recorded distributed in four families, Hesperiidae, Nymphalidae and Pieridae with five species each, and Papilionidae with two species.Key words: Central Brazil, Campo rupestre, Entomological fauna.
Inventário florí­stico do Mosteiro Zen Horyu-Zan Eisho-Ji: contribuições para a criação de uma unidade de conservação no Cerrado
Authors: Rosa Priscila Oliveira , Rivaroli Giulia Vieira , Santos Natália Alves Pereira dos , Alencar Pedro Rodrigues de , Soares Augusto Cesar Alencar , Paiva Valdina Ferreira de , Oliveira Jorge Augusto Souza de , Chacon Roberta Gomes 
Published: March 2021

Pirenópolis apresenta diversas atividades econômicas e, além do agronegócio, pecuária e mineração, o municí­pio tem no ecoturismo uma das fontes de renda mais importantes de arrecadação. Para proteger o patrimônio natural da cidade é preciso aumentar o número de unidades de conservação a fim de perpetuar a biodiversidade do Cerrado e todos os serviços que uma área natural agrega. Desde a primeira visita técnica ao Mosteiro Zen Horyu-Zan Eisho-Ji sua diversidade florí­stica foi constatada. Ao final de um ano de expedição foram coletadas 436 espécies de plantas, de 227 gêneros e 86 famí­lias botânicas, sendo que sete dessas espécies são novas para a comunidade cientí­fica e nove encontram-se em alguma categoria de ameaça da IUCN. Esses atributos apontam para o potencial da propriedade do Mosteiro em se transformar em uma unidade de conservação e, assim, cumprir sua missão de proteger o Cerrado.Palavras-chave: Pirenópolis, florí­stica, espécies ameaçadas, Goiás, Cerrado. Floristic Checklist of the Zen Monastery Horyu-Zan Eisho-Ji: inputs for the creation of a conservation unit in the CerradoPirenópolis presents several economic activities and, in addition to agribusiness, cattle farming and mining, the municipality has the ecotourism as one of the most important sources of income. In order to protect the natural heritage of the region it is necessary to increase the number of conservation units to perpetuate the biodiversity of the Cerrado and all the services that a natural area adds. From the first technical visit to the Zen Monastery Horyu-Zan Eisho-Ji its floristic diversity was confirmed and recorded. At the end of one year of expeditions, we collected 436 species of plants from 227 genera and 86 botanical families, seven of which are new to the scientific community and nine are listed as threatened following the IUCN classification. These attributes point to the potential of the Monastery's property to become a conservation unit and thus fulfill its mission to protect the Cerrado.Keywords: Pirenópolis, floristics, threatened species, Goiás, Cerrado.