bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Atang Atang , Palupi Endah Sri 
Published: February 2021

Plastik merupakan bahan yang banyak dijumpai dalam kehidupan sehari-hari, baik untuk keperluan rumah tangga, perkantoran, pertanian/perkebunan, perindustrian, dan sebagainya. Salah satu jenis plastik yang umum digunakan adalah plastik polikarbonat (polycarbonate/PC). Bahan utama pada pembuatan plastik polikarbonat adalah senyawa 2,2-bis (4-hidroksifenil) propan atau yang dikenal dengan nama bisphenol A (BPA). Tujuan dari penelitian ini untuk mengetahui pengaruh pemberian antioksidan alami tehadap berat testis mencit (Mus musculus) jantan dewasa yang terpapar senyawa kimia penyusun plastik. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 5 ulangan. Perlakuan meliputi dua kelompok kontrol serta 4 kelompok lain mendapat perlakuan air rebusan plastik dan antioksidan alami. ARP dan AO diberikan secara oral ke mencit jantan sebanyak 0,25 ml setiap hari selama penelitian. Data kuantitatif dianalisis menggunakan ANOVA dan BNT. Berdasarkan hasil penelitian yang telah dilakukan, dapat diambil kesimpulan bahwa pemberian antioksidan alami selama 21 hari pada Mencit (Mus musculus) yang terpapar senyawa kimia plastik memberikan pengaruh terhadap penurunan berat testis mencit jantan pada perlakuan K(-) / control negatif. Berdasarkan analisis data melalui uji statistik yang telah dilakukan, rangkaian perlakuan pemberian antioksidan alami terhadap mencit yang terpapar senyawa kimia plastik selama 21 hari tidak memberikan pengaruh yang nyata terhadap berat testis mencit.
Karakteristik Kesetimbangan Adsorpsi Uap Air Film terbuat dari Karboksi Metil Glukomanan-Karagenan dengan Penambahan Gliserol
Authors: Fadilah Fadilah , Susanti Ari Diana , Distantina Sperisa 
Published: February 2021

<p><strong>Abstrak.</strong> Plastik sebagai bahan pengemas mempunyai berbagai kelebihan namun tidak dipungkiri telah menyebabkan pencemaran terhadap lingkungan. Berbagai upaya untuk mengatasi pencemaran tersebut dan salah satunya adalah usaha menggantikan plastic dengan bahan yang ramah lingkungan. Edible film banyak diformulasikan dari berbagai bahan yang biodegradable. Polimer alam berbasis karbohidrat banyak dilirik sebagai sumber pembuatan film karena jumlahnya yang melimpah. Glukomanan merupakan polisakarida yang terdapat dalam umbi porang. Untuk pembuatan edible film, glukomanan dimodifikasi memjadi karboksi metIl glukomanan sebelum dicampur dengan karagenan. Sejumlah gliserol ditambahkan sebagai plastisizer. Pengamatan terhadap kesetimbangan adsorpsi uap air dilakukan dengan metode gravimetri pada kisaran kelembaban relatif 6,1 – 97%. Hasil menunjukkan bahwa film dengan konsentrasi gliserol yang lebih tinggi menunjukkan nilai kesetimbangan kandungan uap air yang lebih tinggi. Model kesetimbangan adsorpsi uap air yaitu persamaan Oswin digunakan untuk menggambarkan perilaku penyerapan air.</p><p> </p><p><strong>Abstract.</strong> Various efforts have done to overcome the enviromental pollution and one of them is to replace plastic with environmentally friendly materials. Glucomannan is a polysaccharide found in porang tubers that can be a source for biodegradable edible film.. For the production of edible film, glucomannan was modified into carboxy methyl glucomannan before it was mixed with carrageenan. Glycerol was added as a plasticizer. The film was made by casting method. Gliserol was added to a mixed solution of carboxy methyl and carrageenan and then poured onto a mold before drying in an electrical oven. Observation of the equilibrium adsorption equilibrium was carried out by gravimetric method for different level of water activity (0.06 – 0.97) and temperature (30, 40 and 50 oC). The results showed that film with higher glycerol concentrations showed higher equilibrium moisture content. The equilibrium adsorption model, the Oswin equation, is used to describe the water absorption behavior with average error at 20,947 – 75,271%.</p><p> </p><p><strong>Keywords:</strong> Carboxymethyl glucomannan-carrageenan film, water vapor equilibrium, Oswin equation.</p>
Two Step and Direct Fermentation in the Production of Ethanol from Starch: A Short Review
Authors: Dyartanti Endah Retno , Margono Margono , Nurohmah Anisa Raditya , Nisa Shofirul Sholikhatun , Riantosa Novan 
Published: February 2021

<p><strong>Abstract.</strong> Ethanol as a renewable fuel has been widely produced in various countries. One source of raw material for producing ethanol is starch. The process of producing ethanol from starch needs to be pretreated so that starch molecules can split into smaller ones. However, this process requires pre-treatment which will expensive more than ethanol from sugar. There are two types of pretreatment i.e. two-step ethanol production and direct fermentation. There is two kind of hydrolysis, acid hydrolysis, and enzymatic hydrolysis. Two-step ethanol production is a conventional method that separates pretreatment and fermentation process, while direct fermentation is the direct production of starch into ethanol using recombinant yeast that co-produces enzymes such as amylose and glucoamylase. Two-step ethanol production has the advantage of high yield but needs high cost whereas, direct fermentation has the advantage of low-cost production but needs longer time. Common starch to ethanol production consists of two stages, namely hydrolysis of raw materials into glucose and fermentation into ethanol. Both of these processes can be run on average at temperatures of 30-80<sup>o</sup>C with a pH range of 4-6 and varying time intervals. The enzyme used depends on the source of the starch, but the most commonly used is <em>Saccharomyces cerevisiae</em>.</p><p><strong>Keywords</strong>: Ethanol, starch, pre-treatment</p>
Special Issue on Disaster Storytelling, in Commemoration of 2020 TeLL-Net Forum, Kobe, Japan
Authors: Nagamatsu Shingo , Sawada Masahiro , Ono Yuichi , Tanaka Naoto , Sakamoto Mayumi , Ishihara Ryoga , Sakato Masaru , Sato Shosuke , Maly Elizabeth 
Published: January 2021

This special issue of the Journal of Disaster Research focuses on disaster storytelling, an emerging concept in disaster risk reduction. Despite its popularity and importance, its individual practices and activities, as they tend to be spontaneous and local, have received only limited attention from academia and have not been given special attention by the disaster research community.
The papers included in this volume contain multi-dimensional discussions on disaster storytelling, including ones that focus on concepts and theory, the functions of disaster museums, tourism, local communities, UNESCO geoparks, disaster ruins and heritage, art and culture, and disaster education. The readers can understand the variety of disaster storytelling activities that exist around the world and their potential contribution to building resilience in society. We believe this issue is the first academic publication to focus specifically on disaster storytelling, and we hope that this volume contributes to creating scientific value, attracts additional attention, and develops further discussions about the role of disaster storytelling within the disaster research community. We also believe that such discussions will help various individuals and entities reidentify the importance and significance of their activities of disaster storytelling as well as contribute to continuing or strengthening such activities around the world.
All of the contributors to this issue participated in the International Forum on Telling Live Lessons from Disasters (TeLL-Net Forum), held January 24–26, 2020 in Kobe, Japan. The articles included in this issue include ones that were inspired by discussions during and after the forum. Readers interested in this forum can obtain the official report from the TeLL-Net website: https://tell-net.jp/forum2020/pdf/00_Tell_Net2020_Report_print.pdf.
We, the editorial board of this special issue, would like to express our deep appreciation to the Hyogo Earthquake Memorial 21st Century Research Institute for the research grant on disaster storytelling. We also would like to express our gratitude to the Kobe Machizukuri Rokko Island Fund Charitable Trust (Tokyo, Japan) and AIG Institute (Osaka, Japan) for financial contributions that supported the publication of the issue.
Inventarisasi Liken di Kawasan Kebun Raya Bogor
Authors: Ramadhanti Zahra Nur , Inggit Amellia Harnum  , Nadia Riza Pratiwi  , Zahra Wihanifa Putri  , Mieke Miarsyah  , Annisa Wulan Agus Utami  
Published: February 2021

Kebun Raya Bogor merupakan salah satu ruang terbuka hijau utama di tengah Kota Bogor yang padat dan sudah ada sejak zaman pemerintahan kolonial Belanda. Kebun Raya Bogor memiliki peran sebagai bank plasma ex-situ. Kebun Raya Bogor menyimpan banyak plasma nutfah dari berbagai cagar alam serta memiliki koleksi tumbuhan hidup sebanyak 3.423 spesies, 1.257 genus dan 222 famili. Namun, liken yang berada di berbagai pohon Kebun Raya Bogor masih kurang diperhatikan dan belum banyak diteliti serta diketahui spesiesnya. Nyatanya terdapat beberapa manfaat yang mungkin diperoleh dalam meneliti liken di Kebun Raya Bogor ini, salah satunya yaitu dapat mengetahui kualitas udara di sekitar kawasan Kebun Raya Bogor. Tujuan penelitian ini adalah untuk mengetahui spesies liken yang sering dijumpai di kawasan Kebun Raya Bogor. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Lokasi pengamatan ditentukan dengan menggunakan teknik purposive sampling, ditentukan tiga stasiun sebagai perwakilan populasi liken di Kebun Raya Bogor. Hasil penelitian menunjukkan bahwa liken dengan jenis talus crustose mendominasi dibanding jenis talus lainnya. Diperoleh 17 spesies liken dengan tipe talus crustose sebanyak 10 spesies, foliose sebanyak 6 spesies, dan fructicose sebanyak 1 spesies. Tujuh belas spesies tersebut tergolong kedalam sepuluh famili, yaitu Arthoniaceae, Caliciaceae, Candelariaceae, Cladonia, Graphidaceae, Lecanoraceae, Parmeliaceae, Phlyctidaceae, Crocyniaceae, Stereocaulaceae. Famili Arthoniaceae merupakan famili yang paling banyak ditemukan dengan nilai persentase sebesar 27%. Spesies dari famili tersebut, Cryptothecia scripta merupakan spesies yang paling banyak ditemukan dengan presentase sebesar 21%. Jenis talus liken sangat erat kaitannya dengan kemampuan liken tersebut bertahan pada kondisi lingkungan yang ada.
Оценка корреляционной связи между результатами исследования образцов плазмы крови доноров-реконвалесцентов, перенесших коронавирусную инфекцию COVID-19, в тест-системе «ДС-ИФА-АНТИ-SARS-COV-2-G» и в реакции нейтрализации
Authors: Матвеева Елена , Макарова Ирина , Фисенко Наталия , Обрядина Анна 
Published: February 2021

Проведена работа по оценке корреляционной связи между результатами исследования образцов плазмы крови доноров, перенесших коронавирусную инфекцию COVID-19, в тест-системе «ДС-ИФА-АНТИ-SARS-COV-2-G», производства ООО «НПО «Диагностические системы» (г. Нижний Новгород), и в реакции нейтрализации (РН). В качестве объектов исследования использовали 49 образцов плазмы крови доноров-реконвалесцентов COVID-19 с установленным титром вируснейтрализующих антител (ВНА) для каждого образца.
По результатам исследования была установлена статистически значимая корреляция между титром антител класса G к SARS-COV-2 в иммуноферментном анализе (ИФА) и титром ВНА, а также значениями оптической плотности (ОП), коэффициента позитивности (КП) в ИФА и титром ВНА в плазме крови доноров. Коэффициент корреляции Спирмена составил 0,948 и 0,837 соответственно, при уровне значимости р<0,0001. Чувствительность и специфичность тест-системы «ДС-ИФА-АНТИ-SARS-COV-2-G» при тестировании образцов от потенциальных доноров гипериммунной плазмы составили 100% и 85,7% соответственно, по критерию титра антител ≥1600, и 100% и 91,4% по критериям ОП ≥3,000 (КП ≥ 9,6).
Explaining the Individual Challenges Experienced of Women Affected by Neuromyelitis Optica and Multiple Sclerosis: A Comparative Content Analysis Study
Authors: Shabany Maryam , Ayoubi Saeideh , NaserMoghadasi Abdorreza , Eskandarieh Sharareh 
Published: February 2021

Abstract
Introduction: Multiple Sclerosis (MS) and Neuro-Myelitis Optica spectrum disorder (NMOSD) are an autoimmune condition. Both of them have unexpected and acute relapses. The aim of this qualitative study was explaining the individual problems experienced of women affected by NMOSD and MS.Method: Sixteen NMOSD patients and eighteen MS patients completed a face to face deep semi-structured interview. Participants were recruited from the MS ward in Sina hospital. After typed the interview, the data were analyzed using conventional content analysis, as recommended by Graneheim and Lundman (2005). Data analysis is managed with MAXQDA2018 software.Results: In this study, a common theme for both disease groups was identified as "challenges arising from personal problems". The categories are named after each other and have many similarities, which in the NMOSD group include four categories including: "From uncertainty to the perception of threat", "Living with limitations", "Active coping until normalization" and "Facilitators of personal problems" appeared. In the group of patients with MS, five categories emerged: "perceived threat", living at a bottleneck, trying to deal with negative experiences, "facilitators of personal problems" and "problems related to physical rehabilitation".Conclusion: This qualitative study showed that the individual problems of the two groups of NMOSD and MS patients are somewhat similar. Also in the present study, people with MS need longer-term rehabilitation care than people with NMOSD, which should be considered and examined, a need that was less seen in people with NMOSD. The unpredictability of attacks in NMOSD and MS can have a profound effect on the daily lives of these people. Therefore, educating patients and staff about how to manage life in such diseases can be an important help to improve patient's health.
Maternal Body Mass Index and Ethnicity in Relation to The Adverse Outcomes of Large for Gestational Age and Gestational Diabetes Mellitus in a Retrospective Cohort of Australian Pregnant Women.
Authors: Knight-Agarwal Catherine , Rati Jani , Al-Foraih Meisa , Eckley Dionne , Lui Carrie Ka Wai , Somerset Shawn , Davis Deborah , Takito Monica Yuri 
Published: February 2021

Abstract
Background: The prevalence of maternal overweight and obesity has been increasing. This research explored the association between maternal body mass index and ethnicity in relation to the adverse outcomes of large for gestational age and gestational diabetes mellitus. Method: A retrospective cohort study was undertaken with 27 814 Australian women of various ethnicities, who gave birth to a singleton infant between 2008 and 2017. Variables were examined using logistic regression. Results: A significantly higher proportion of large for gestational age infants were born to overweight and obese women compared to those who were classified as underweight and healthy weight. Asian-born women with a body mass index of ≥ 40kg/m2 had an adjusted odds ratio of 9.926 (3.859 - 25.535) for birthing a large for gestational age infant whereas Australian-born women had an adjusted odds ratio of 2.661 (2.256 - 3.139) for the same outcome. Women born in Australia were at high risk of birthing a large for gestational age infant in the presence of insulin controlled gestational diabetes mellitus, but this risk was not significant for those with the diet-controlled type. Asian-born women did not present an elevated risk of birthing a large for gestational infant, in either the diet controlled, or insulin controlled gestational diabetes mellitus groups. Conclusion: Large for gestational age and gestational diabetes mellitus are adverse pregnancy outcomes that can lead to significant maternal and neonatal morbidity. Women who are overweight or obese, and considering a pregnancy, are encouraged to seek culturally appropriate nutrition and weight management advice during the periconception period.
Berezinskii-Kosterlitz-Thouless Phase Induced by Dissipating Quasisolitons
Authors: Gawryluk Krzysztof , Brewczyk Mirosław 
Published: February 2021

Abstract
We theoretically study the sound propagation in a two-dimensional weakly interacting uniform Bose gas. Using the classical fields approximation we analyze in detail the properties of density waves generated both in a weak and strong perturbation regimes. While in the former case density excitations can be described in terms of hydrodynamic or collisionless sound, the strong disturbance of the system results in a qualitatively different response. Within this regime we identify observed structures as quasisolitons and uncover their internal complexity. Quasisolitons break into vortex pairs as time progresses, eventually reaching an equilibrium state. We find this state, characterized by only fluctuating in time averaged number of pairs of opposite charge vortices and by appearance of a quasi-long-range order, as the Berezinskii-Kosterlitz-Thouless (BKT) phase.
PITPNA-AS1 Activated by H3K27ac&nbsp;Sponged miR-98-5p&nbsp;to Regulate Cisplatin Resistance in Gastric Cancer
Authors: Liu Yaping , Zhao Xu , Chen Yinnan , Guo Gang , Wang Jiansheng , He Shuixiang 
Published: February 2021

Abstract
To evaluate the expression of PITPNA-AS1 and miR-98-5p in gastric cancer tissues as well as their association with progression of gastric cancer, and investigate the role of PITPNA-AS1 and miR-98-5p in developing platinum resistance. RNA sequencing was used to identify candidate lncRNAs and microRNAs related to local recurrence of gastric cancer. qRT-PCR was used to investigate the expression of PITPNA-AS1 and miR-98-5p. CCK-8 and caspase3/7 activity were used to evaluate the cell proliferation and apoptosis rate. Dual luciferase reporter gene assay and RNA pull down were used to evaluate the cross talk between PITPNA-AS1 and miR-98-5p. PITPNA-AS1 and miR-98-5p could regulate cell proliferation and inhibit apoptosis in gastric cancer cell lines. Cisplatin and lobaplatin could significantly suppress the expression of PITPNA-AS1, which interacted with negatively regulated miR-98-5p expression. PITPNA-AS1 overexpression impaired the effect of platinum, which was partially reversed by downregulation of miR-98-5p knock down. In gastric cancer, PITPNA-AS1 and miR-98-5p could regulat cell growth, apoptosis and platinum resistance. They have the potential to be biomarkers and curative therapeutic targets. However, further research on molecular mechanisms are needed.
Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through miR-221-3p-mediated Enhancement of Angiogenesis
Authors: Wei Qian , Wang Yaxi , Ma Kui , Bian Xiaowei , Li Qiankun , Li Bingmin , Hu Wenzhi , Li Haihong , Fu Xiaobing , Zhang Cuiping 
Published: February 2021

Abstract
Background: Endothelial dysfunction caused by persistent hyperglycemia in diabetes is responsible for impaired angiogenesis in diabetic wounds. Exosomes are considered potential therapeutic tools to promote diabetic wound healing. The aim of this study was to investigate the effects of exosomes secreted by human umbilical cord mesenchymal stem cells (hucMSC-Exos) on angiogenesis under high glucose (HG) conditions in vivo and in vitro and to explore the underlying mechanisms.Methods: HucMSC-Exos were used to treat diabetic wounds and human umbilical vascular endothelial cells (HUVECs) exposed to HG. Wound healing and angiogenesis were assessed in vivo. The biological characteristics of HUVECs were examined in vitro. Expression of pro-angiogenesis genes in HUVECs was also examined by western blotting. The miRNAs contained within hucMSC-Exos were identified using miRNA microarrays and qRT-PCR. The roles of selected miRNAs in angiogenesis were assessed using specific agomirs and inhibitors.Results: In vivo, local application of hucMSC-Exos enhanced wound healing and angiogenesis. In vitro, hucMSC-Exos reduced senescence of HG-treated HUVECs and promoted proliferation, migration, and tube formation by inhibiting phosphatase and tensin homolog (PTEN) expression and activating the AKT/HIF-1α/VEGF pathways. MiR-221-3p was enriched in hucMSC-Exos. In vitro, MiR-221-3p downregulated PTEN and activated the AKT/HIF-1α/VEGF pathway to promote proliferation, migration, and tube formation in HG-treated HUVECs. In vivo, miR-221-3p agomirs mimicked the effects of hucMSC-Exos on wound healing and angiogenesis, whereas miR-221-3p inhibitors reversed their effects.Conclusions: Our findings suggest that hucMSC-Exos have regenerative and protective effects on HG-induced senescence in endothelial cells via transfer of miR-221-3p, thereby accelerating diabetic wound healing. Thus, hucMSC-Exos may be promising therapeutic candidates for improving diabetic wound angiogenesis.
Ultrasound-Stimulated Microbubbles Enhance Radiation-induced Cell Killing
Authors: McCorkell Giulia , Nakayama Masao , Feltis Bryce , Piva Terrence , Geso Moshi 
Published: February 2021

Abstract
Background: There has been recent interest in the use of ultrasound-stimulated microbubbles (USMB) as a localised radiosensitiser, with in vivo studies to date demonstrating impressive results. In vitro results have focussed primarily on Human Umbilical Vein Endothelial Cells (HUVEC), and studies using other cell lines have shown varying results. This study aims to further investigate any increases in radiation-induced cell killing in vitro using HUVECs and two carcinoma cell lines; and to study the effect different radiation energies have on cells treated with ultrasound-stimulated microbubbles and radiation.Methods: HUVEC, Metastatic Follicular Thyroid Carcinoma cells (FTC-238) and Non-Small Cell Lung Carcinoma cells (NCI-H727) were treated using a combination of 1.6% v/v microbubbles (Definity®); ~90 seconds of 2MHz ultrasound with a mechanical index of 0.8; and 0-6Gy of kV or MV x-rays. Cell viability was measured using a cell viability assay 72 hours post-treatment, and normalised survival calculated relative to untreated controls. Statistical significance was determined using a Three-Way Analysis of Variance (ANOVA) after confirming equal variance existed across all groups.Results: All cells treated with combined USMB and radiation demonstrated decreased normalised survival, with statistically significant effects observed for the NCI-H727 cells. Statistically significant differences in the effect of kV and MV radiation were also observed for FTC-238 cells.Conclusions: USMB and Radiation Therapy significantly reduced the viability of NCI-H727 cells when compared to cells exposed to radiation treatment only. Decreased cell viability was also observed in HUVEC and FTC-238 cells, but this was not significant. Further studies using increased Microbubble concentrations may be required to achieve statistically significant results as reported elsewhere. Similarly, further research is needed to understand the differing effect of kV and MV x-rays on the survival of FTC-238 cells.