bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19
Authors: Hashimoto Shoji , Yoshizaki Kazuyuki , Uno Kazuko , Kitajima Heita , Arai Tsuyoshi , Tamura Yoshitaka , Morishita Hiroshi , Matsuoka Hiroto , Han Yuki , Minamoto Seijiro , Hirashima Tomonori , Yamada Tomoki , Kashiwa Yozo , Kameda Makoto , Yamaguchi Seiji , Tsuchihashi Yasunari , Iwahashi Mitsuhiro , Nakayama Emi , Shioda Tatsuo , Nagai Takayuki , Tanaka Toshio 
Published: September 2021

Background and Aim: Tocilizumab, a humanized anti-IL-6 receptor antibody, has been used to treat severely to critically ill patients with COVID-19. A living systematic review with meta-analysis of recent RCTs indicates that the combination therapy of corticosteroids and tocilizumab produce better outcomes, while previous observational studies suggest that tocilizumab monotherapy is beneficial for substantial numbers of patients. However, what patients could respond to tocilizumab monotherapy remained unknown.Methods: In this retrospective study we evaluated the effects of tocilizumab monotherapy on the clinical characteristics, serum biomediator levels, viral elimination, and specific IgG antibody induction in 13 severely to critically ill patients and compared with those of dexamethasone monotherapy and dexamethasone plus tocilizumab.Results: A single tocilizumab administration led to a rapid improvement in clinical characteristics, inflammatory findings, and oxygen supply in 7 of 11 patients with severe COVID-19, and could recover from mechanical ventilation management (MVM) in 2 patients with critically ill COVID-19. Four patients exhibited rapidly worsening even after tocilizumab administration and required MVM and additional methylprednisolone treatment. Tocilizumab did not delay viral elimination or inhibit IgG production specific for the virus, whereas dexamethasone inhibited IgG induction. A multiplex cytokine array system revealed a significant increase in the serum expression of 54 out of 80 biomediators in patients with COVID-19 compared with that in healthy controls. Compared with those who promptly recovered in response to tocilizumab, patients requiring MVM showed a significantly higher ratio of basal level of ferritin/CRP and a persistent increase in the levels of CRP and specific cytokines and chemokines including IL-6, IFN-γ, IP-10, and MCP-1. The basal high ratio of ferritin/CRP was also associated with clinical deterioration even in patients treated with dexamethasone and tocilizumab.Conclusion: Tocilizumab as monotherapy has substantial beneficial effects in some patients with severe COVID-19, who showed a relatively low level of the ratio of ferritin/CRP and prompt reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1. The high ratio of ferritin/CRP is associated with rapid worsening of pneumonia. Further evaluation is warranted to clarify whether tocilizumab monotherapy or its combination with corticosteroid is preferred for severely to critically ill patients with COVID-19.
Androgen Receptor Targeted Therapy + Radiotherapy in Metastatic Castration Resistant Prostate Cancer
Authors: Massaro Maria , Facondo Giuseppe , Vullo Gianluca , Aschelter Anna Maria , Rossi Alessandro , De Sanctis Vitaliana , Marchetti Paolo , Osti Mattia Falchetto , Valeriani Maurizio 
Published: September 2021

ObjectivesTo investigate whether radiotherapy as metastasis-directed therapy (MDT) on oligo-progressive sites in metastatic castration-resistant prostate cancer (mCRPC) patients during treatment with androgen receptor-targeted therapy (ARTT) may lead to control resistant lesions, prolonging ARTT. We analysed progression free survival, overall survival and prognostic parameters that can identify patients that best suit to this approach.Patients and MethodsRetrospective analysis of a total of 67 lesions in 42 mCRPC patients treated with ablative or palliative RT to oligoprogressive lesions during ARTT. Twenty-eight patients (67%) underwent ARTT with Abiraterone acetate and 14 patients (33%) underwent ARTT with Enzalutamide. Median time between the start of ADT and ARTT beginning was 50.14 months (range 3.37-219 months). We treated 58 lesions (87%) with 3D conformal radiotherapy (3DCRT) and nine lesions (13%) with stereotactic body radiotherapy (SBRT). The Kaplan Meier method was used to assess the median overall survival (OS) and the progression-free survival (PFS).ResultsMedian follow-up was 28 months (range 3-82 months). Median OS was 32.5 months (95% CI 25.77-39.16), 1 and 2-year OS were 71.6% and 64.1%, respectively. Median PFS was 19,8 months (95% CI 11.34–28.31), 1 and 2-year PFS were 67.2% and 47.4%, respectively. Median OS for patients that underwent radiotherapy before 6 months from the start of ARTT was 23.4 months (95% CI 2.04-44.89) and 45.5 months (95% CI 31.19-59.8) for patients that underwent radiotherapy after 6 months (p = 0.009).ConclusionLocal ablative radiation therapy directed to progressive metastasis is a non-invasive, well tolerated treatment with efficacy on prolonging clinical benefit of systemic therapies with ARTT. Patients who underwent RT &gt;6 months from the start of ARTT presented a statistically better OS and PFS compared with patients who underwent radiotherapy &lt;6 months from the start of ARTT.
Functional and Oncological Outcomes Following Robot-Assisted and Laparoscopic Radical Prostatectomy for Localized Prostate Cancer With a Large Prostate Volume: A Retrospective Analysis With Minimum 2-Year Follow-Ups
Authors: Deng Wen , Liu Xiaoqiang , Liu Weipeng , Zhang Cheng , Zhou Xiaochen , Chen Luyao , Guo Ju , Wang Gongxian , Fu Bin 
Published: September 2021

ObjectiveWe aimed to analyze the perioperative, functional, and oncologic outcomes following robot-assisted radical prostatectomy (RARP) and laparoscopic radical prostatectomy (LRP) for patients with localized prostate cancer (PCa) characterized by a large prostate volume (PV; ≥50 ml) over a minimum of 2 years follow-up.Materials and MethodsPatients undergoing RARP and LRP for localized PCa with a large PV were included in the final analysis. The perioperative, functional, and oncologic outcomes were analyzed between the two groups.ResultsAll operations were successfully completed without open conversion in both groups. The mean operative time and estimated blood loss in the RARP group were significantly decreased compared to those in the LRP group (139.4 vs. 159.0 min, p = 0.001, and 124.2 vs. 157.3 ml, p = 0.003, respectively). Patients in the RARP arm had significantly lower proportions of grade II or lower and of higher than grade II postoperative complications compared with those in the LRP group (7.9% vs. 17.1%, p = 0.033, and 1.6% vs. 6.7%, p = 0.047, respectively). No significant differences in terms of the rates of pT3 disease, positive surgical margin, and positive lymph node were noted between the two groups. Moreover, no significant difference in the median specimen Gleason score was observed between the RARP and LRP groups (6 vs. 7, p = 0.984). RARP vs. LRP resulted in higher proportions of urinary continence upon catheter removal (48.4% vs. 33.3%, p = 0.021) and at 3 (65.1% vs. 50.5%, p = 0.025) and 24 (90.5% vs. 81.0%, p = 0.037) months post-operation. The median erectile function scores at 6 and 24 months post-operation in the RARP arm were also significantly higher than those in the LRP arm (15 vs. 15, p = 0.042, and 15 vs. 13, p = 0.026, respectively). Kaplan–Meier analyses indicated that the biochemical recurrence-free survival and accumulative proportion of continence were statistically comparable between the two groups (p = 0.315 and p = 0.020, respectively).ConclusionsFor surgically managing localized PCa with a large prostate (≥50 ml), RARP had a tendency toward a lower risk of postoperative complications and better functional preservation without cancer control being compromised when compared to LRP.
Birth Weight and Subsequent Risk of Total Leukemia and Acute Leukemia: A Systematic Review and Meta-Analysis
Authors: Che Hailuo , Long Dunmei , Sun Qian , Wang Lina , Li Yunbin 
Published: September 2021

Objective:Birth weight, an important indicator of fetal nutrition and degree of development, may affect the risk of subsequent leukemia. At present, little is known about the effect of birth weight on acute myeloid leukemia (AML) and whether there is a dose-dependent relationship of birth weight with acute lymphoid leukemia (ALL) and AML. To address these questions, the present work aimed to systematically investigate the relationship between birth weight and the risk of subsequent leukemia based on the current epidemiological studiesMethods:Relevant studies were systematically retrieved from electronic databases PubMed, Embase, and Cochrane Library, from inception to May 15th, 2021. Finally, 28 studies (including 21 case-control studies and 7 cohort studies) were included for the final meta-analysis. Results in cohort studies were performed by risk ratios (RRs), while those in case-control studies by odds ratios (ORs), and all results were assessed by adopting the random-effect model. Besides, a dose-dependent analysis was conducted based on the cohort studies.Results:Compared with the population with normal birth weight (NBW), the population with high birth weight (HBW) might have an increased risk of leukemia (OR 1.33, 95%CI 1.20–1.49;I20%). Meanwhile, low birth weight (LBW) was associated with a decreased risk of ALL, as evidenced from the pooled analysis of case-control studies (OR 0.83, 95% CI 0.75–0.92;I223.3%). However, relative to NBW population, the HBW population might have an increased risk of ALL (OR 1.28, 95% CI 1.20–1.35;I27%). There was no obvious evidence supporting the relationship between LBW and the risk of AML from the pooled analysis of case-control studies (OR, 1.11 95% CI 0.87–1.42;I231.7%).Conclusions:Overall, in children and young adults, HBW population may be associated with the risks of subsequent leukemia and AML relative to NBW population, but the supporting dose-dependent evidence is lacking. In addition, compared with NBW population, there is stronger evidence supporting a significantly increased risk of subsequent ALL in HBW population, and a decreased risk in LBW population in a dose-dependent manner. More prospective studies with large samples are warranted in the future to validate and complement these findings.
Syrian Refugee Youth Resettled in Norway: Mechanisms of Resilience Influencing Health-Related Quality of Life and Mental Distress
Authors: Dangmann Cecilie , Solberg Øivind , Myhrene Steffenak Anne Kjersti , Høye Sevald , Andersen Per Normann 
Published: September 2021

Background: The importance of resilience factors in the positive adaptation of refugee youth is widely recognised. However, their actual mechanism of impact remains under-researched. The aim of this study was therefore to explore protective and promotive resilience mechanisms to inform future interventions and policy. Promotive resilience is seen as a direct main effect and protective resilience as a moderating effect.Methods: This was a cross-sectional study of Syrian youth recently resettled in Norway, aged 13–24 years. Regression and moderation analyses were used to explore different interactions, including moderated mediation using the PROCESS macro for SPSS.Result: A direct main effect of promotive resilience was found for health-related quality of life (HRQoL) and general mental distress, but not for post-traumatic stress disorder (PTSD). No moderating effects of protective resilience were found. Post-migration stressors mediated the effects of potentially traumatic events (PTE) from war and flight, and this indirect effect was present at all levels of resilience.Conclusion: Despite high risk exposure and mental distress, resilience was also high. Broad resilience interventions targeting multiple factors would likely benefit the group, but these should include both individual assets and building supportive environments. Additionally, reducing current stress and providing treatment for those in need could enable recovery and increase the efficacy of resilience factors already present.
Comparison of Different Staging Systems Applied to a Cohort of Patients With Oral Tongue and Floor of the Mouth Cancer
Authors: Bresciani Lorenzo , Giannini Lorenzo , Paderno Alberto , Incandela Fabiola , Fontanella Walter , Mattavelli Davide , Piazza Cesare 
Published: September 2021

Purpose: The present work compares the effects produced by the application of the 7th edition of the tumor node metastasis (TNM) staging system (TNM7), 8th Edition (TNM8) with its two subsequent revisions, and pN-N+ classification on a cohort of patients with oral tongue and floor of the mouth cancer.Methods: A monocentric cohort of 148 patients was retrospectively analyzed. Patients were staged according to the TNM7, TNM8 and revisions, and pN-N+ classification. Stage migration was assessed and overall survival (OS) analyzed with the Kaplan–Meier method. The pT, pN, and stage stratification was evaluated with univariate and multivariate Cox regression and comparing adjacent categories with the log-rank method.Results: pT3-T4a categories showed significant differences in comparison to pT1-T2 for each staging metric employed in both uni- and multivariate analysis. When comparing adjacent pT categories, OS was significantly different only between pT2 and pT3 categories of the TNM8. Disproportionate patient distribution among pN categories was observed in the TNM8, and stratification was scarce. Conversely, in the pN-N+ classification the difference between pN2 and pN3a categories was significant. Only stage IVa reached statistical significance in TNM7, whereas stage III and above were significant in TNM8 and revisions in both uni- and multivariate analysis. However, no significant difference was noted comparing adjacent stages.Conclusion: The TNM8 pT classification differentiated low- from high-risk diseases. Nonetheless, it failed to separate pT1 from pT2 and pT3 from pT4a categories. Conversely, although TNM8 nodal staging was inaccurate, the number of metastatic lymph nodes was more valuable.
Updated Evaluation of Laparoscopic vs. Open Appendicectomy During Pregnancy: A Systematic Review and Meta-Analysis
Authors: Zhang Jia , Wang Miye , Xin Zechang , Li Ping , Feng Qingbo 
Published: September 2021

To explore the updated evaluation about the obstetrical and perioperative outcomes of laparoscopic appendicectomy (LA) for pregnancy appendicitis compared with open appendicectomy (OA). Two reviewers independently searched the PubMed, the Cochrane Central Register of Controlled Trials, EMBASE, and Web of Science databases to screen eligible studies up to December 2020. Only clinical researches, no &lt; 10 cases for LA and OA group were included. Twenty retrospective studies with 7,248 pregnant women, evaluating LA and OA in surgical and obstetrical outcomes, were included. The weighted mean difference (WMD) with 95% CI and odds ratio (OR) was used to compare continuous and dichotomous variables. It seems LA was connected with significantly shorter hospital time and lower wound infection [mean difference (MD), −0.57 days; 95% CI, −0.96 to −0.18;p= 0.004 and OR, 0.34; 95% CI, 0.18 to 0.62;p= 0.0005, respectively]. The incidence of fetal loss after LA was higher than OA (OR,1.93; 95% CI, 1.39–2.69;p&lt; 0.0001). It was almost similar in the rate of preterm delivery (OR, 0.80; 95% CI, 0.48 to 1.34;p= 0.40) and other perioperative and obstetrical complications (p&gt; 0.05). Our results indicated that the occurrence of fetal loss after LA should not be ignored. Caution, skillful operation, and thoroughly informed consent about the advantages and disadvantages of laparoscopy are necessary.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier: CRD42021233150.
Influência do programa de Educação pelo Trabalho na atuação em saúde bucal do agente comunitário de saúde
Authors: Soares Luan Kayru da Cruz , Lima Wilkelly Alves de , Pereira Fabricio Moraes , Fontes Rosely Barbosa da Cunha , Arantes Diandra Costa , Pontes Flávia Sirotheau Corrêa , Nascimento Liliane Silva do 
Published: September 2021

Objetivo: Avaliar a influência das ações realizadas pelo Programa de Educação pelo Trabalho (PET-Saúde) no trabalho e conhecimento em saúde bucal de Agentes Comunitários de Saúde (ACS). Método: Para a análise da influência do conhecimento em saúde bucal do ACS pela foi realizado estudo transversal desenvolvido em dois distritos administrativos municipais através de instrumento validado. Os dados obtidos foram analisados estatisticamente pelo SPSS. Resultados: Os ACS eram em maioria do sexo feminino com idade entre 30 a 39 anos, e renda familiar de um a três salários, a maioria residia na comunidade há mais de seis anos e atua na comunidade entre 1 e 3 anos, abrangendo cerca de 500 a 599 indivíduos na sua microárea. Observou-se que a maioria dos ACS não realiza atividade de educação em saúde bucal por não terem recebido capacitação para tal, com exceção dos ACS do distrito administrativo sob área de cobertura da Universidade Federal do Pará. Sobre o conhecimento em saúde bucal, os ACS dos distritos DAGUA e DASAC obtiveram nível moderado. Conclusões: O PET-Saúde proporcionou construção coletiva do conhecimento para os ACS retornando em mudanças positivas sobre o cuidado em saúde bucal para as comunidades. Percebeu-se maior nível de conhecimentos relacionados à saúde bucal entre os ACS do DAGUA, apesar de não ter havido grande diferença entre os distritos analisados. As atividades do PET deveriam ser incorporadas nos projetos pedagógicos, dos cursos de graduação e ter caráter de continuidade nas comunidades fortalecendo as ações de integração ensino-serviço-comunidade.
Completude do esquema vacinal contra a hepatite B segundo registros de imunização
Authors: Souza Rhillary Lorrayne de , De Jesus Carvalho Helenice Rita , Souza Meriele Sabrina de , Oliveira Valéria Conceição de , Guimarães Eliete Albano de Azevedo , Lopes Jéssica Pereira 
Published: September 2021

Objetivo: Analisar a completude do esquema vacinal contra hepatite B (recombinante) de adultos em município de Minas Gerais, segundo registros de imunização no Sistema de Informação do Programa Nacional de Imunização (SIPNI). Métodos: Estudo transversal, descritivo e analítico realizado à partir da base de dados do SIPNI, em 2019. Foram analisados 654 registros de pessoas vacinadas contra a hepatite B (recombinante). Resultados: Identificou-se que apenas 10,55% dos vacinados completaram o esquema vacinal contra hepatite B (recombinante). Indivíduos do sexo feminino apresentaram 3,23 vezes mais chances de ter esquema vacinal completo se comparado com o sexo masculino e aqueles com 50 anos e mais têm 2,77 vezes mais chances de ter esquema completo se comparados com indivíduos de 25 a 49 anos. O tempo médio para fechamento do esquema vacinal foi de 244 dias. Conclusão: O presente estudo apontou para uma baixa completude no esquema vacinal contra hepatite B.
Identifikasi Spasial Kualitas Lingkungan Permukiman Kumuh Di Kelurahan Semanggi Kota Surakarta
Authors: Taji Andhika Bangun 
Published: September 2021

Penelitian ini mengkaji kualitas lingkungan permukiman kumuh di daerah pinggiran kota khususnya di Kelurahan Semanggi Kota Surakarta. Tujuan penelitian ini adalah (1) Menjelaskan kualitas lingkungan permukiman kumuh di Kelurahan Semanggi setelah adanya program KOTAKU, (2) Mengidentifikasi faktor dan variabel yang berpengaruh terhadap kualitas permukiman Kumuh Kelurahan Semanggi. Metode penelitian yang digunakan dalam penelitian ini metode penelitian deduktif kuantitatif. Teknik sampling yang digunakan adalah teknik proporsional random sampling. Responden penelitian ini adalah kepala keluarga yang berasal dari data verifikasi keluarga miskin Kota Surakarta tahun 2019. Teknik analisis data dengan menggunakan metode interpretasi penginderaan jauh, skoring dan pembobotan, uji korelasi Spearman, uji regresi ganda dan analisis deskriptif kualitatif dengan menggunakan tabel silang. Hasil penelitian ini adalah (1) Kelurahan Semangi pada tahun 2021 setelah adanya program KOTAKU telah berhasil menurunkan luasan kekumuhan dari 76,03 ha menjadi 18,36 ha. Pengurangan tersebut antara lain sebesar 38,05 ha (50,04%) mempunyai kualitas lingkungan permukiman baik, dan sebesar 19,62 ha (25,72%) mempunyai kualitas lingkungan permukiman sedang; (2) Dari hasil uji statistik regresi linier berganda didapatkan hasil bahwa faktor-faktor yang berpengaruh terhadap kualitas lingkungan permukiman adalah kepadatan bangunan, keteraturan bangunan dan pengelolaan persampahan dan yang kurang berpengaruh adalah tingkat penghasilan kepala keluarga dan tingkat pengeluaran kepala keluarga.
Kinerja Keuangan Perusahaan Industri Baja Nasional Sebelum dan Sesudah Diterbitkannya Peraturan Menteri Perdagangan No. 22 Tahun 2018
Authors: Inayatullah Mochamad Riza , Mulyana Bambang 
Published: September 2021

Dalam meningkatkan laju pertumbuhan ekonomi dengan melalui pengembangan infrakstruk. Pemerintah merencanakan membangun proyek yang dianggap strategis dan yang paling urgent. Penelitian ini bertujuan untuk mengkaji kinerja keuangan sebelum dan sesudah diterbitkannya Peraturan Menteri Perdagangan No. 22 (Permendag) Tahun 2018 tentang Tata Niaga Impor Besi atau Baja dengan menggunakan rasio likuiditas, rasio solvabilitas, rasio profitabilitas, dan rasio aktivitas. Penelitian ini menggunakan data emiten sub sektor logam dan sejenisnya yaitu perusahaan yang bergerak dalam industri baja. Teknik pengambilan sampel yang digunakan adalah sampel jenuh. Terdapat 8 perusahaan yang memenuhi kriteria sebagai sampel. Metode analisa yang dipakai adalah statistik deskriptif dan One Way Anova (Analysis of Variance). Hasil penelitian menunjukkan bahwa CR, QR, CaR, DER, DAR, CCR, ICR, ROA, PTO, dan TATO mengalami perubahan signifikan sejak diterbitkannya peraturan. Sedangkan pada GPM, NPM, ROE, BEP, ITO, dan RTO tidak mengalami perubahan yang signifikan sejak diterbitkannya peraturan.