bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible Topochemical Polymerization and Depolymerization of a Crystalline Three-Dimensional Porous Organic Polymer with C–C Bond Linkages
Authors: Sun Chenyue , Oppenheim Julius , Skorupskii Grigorii , Yang Luming , Dinca Mircea 
Published: October 2021

Abstract
Three-dimensionally connected porous organic polymers are of interest because of their potential in adsorption, separation, and sensing, among others. When crystalline, they also afford accurate structure description, which in turn can enable particular functions. However, crystallization of three-dimensional (3D) polymers is challenging. This is especially true when targeting polymerization via stable C–C bonds, whose formation is usually irreversible and does not allow for error correction typically required for crystallization. Here, we report polyMTBA, the first 3D-connected crystalline organic polymer with permanent porosity, here formed via C–C linkages. High crystallinity is achieved by solid-state topochemical reaction within monomer MTBA crystals. polyMTBA is recyclable via thermal depolymerization and is solution-processable via its soluble monomers. These results reveal topochemical polymerization as a compelling methodology for generating stable, crystalline, and porous 3D organic frameworks.
Changes in DNA Methylation During Pregnancy and After Delivery
Authors: Lin Ming-Wei , Tsai Mong-Hsun , Shih Ching-Yu , Tai Yi-Yun , Lee Chien-Nan , Lin Shin-Yu , Li Hung-Yuan 
Published: October 2021

Abstract
Background

Gestational adaptation takes place soon after fertilization and continues throughout pregnancy, while women return to a pre-pregnancy state after delivery and lactation. However, little is known about the role of DNA methylation in the fine tuning of maternal physiology. In this study, we investigated whether and how the DNA methylation pattern changes in the three trimesters and after delivery in ten uncomplicated pregnancies.
Results

DNA methylation was measured using Human MethylationEPIC BeadChip. There are 14,018 CpG sites with statistically significant changes in DNA methylation over the four time periods (p < .001). Overall, DNA methylation of the non-pregnant state was higher than that of the three trimesters (p < .001), with the protein ubiquitination pathway the top canonical pathway involved. We classified these CpG sites into nine groups according to the changes in the three trimesters. During pregnancy, most CpG sites (61.63%) had subtle or no changes in DNA methylation (Group 9). There were 3,173 (22.64%) CpG sites in Group 7 and 995 (7.1%) CpG sites in Group 8, which were the two groups with DNA methylation changes between the first and second trimesters. The top systems involved in these two groups were associated with embryonic development and organ morphological changes, as shown by the IPA analysis.
Conclusion

The DNA methylation pattern changes between trimesters, which may be involved in maternal adaptation to pregnancy. Meanwhile, the DNA methylation patterns during pregnancy and in the postpartum period were different, implying that puerperium repair may also act through DNA methylation mechanisms.
ML-WiGR: A Meta Learning based Approach for Cross-Domain Device-Free Gesture Recognition
Authors: Gao Zhenyue , Xue Jianqiang , Zhang Jianxing , Xiao Wendong 
Published: October 2021

Abstract
Accurate sensing and understanding of gestures can improve the quality of human-computer interaction, and has great theoretical significance and application potentials in the fields of smart home, assisted medical care, and virtual reality. Device-free wireless gesture recognition based on WiFi Channel State Information (CSI) requires no sensors, and has a series of advantages such as permission for non-line-of-sight scenario, low cost, preserving for personal privacy and working in the dark night. Although most of the current gesture recognition approaches based on WiFi CSI have achieved good performance, they are difficult to adapt to the new domains. Therefore, this paper proposes ML-WiGR, an approach for device-free gesture recognition in cross-domain applications. ML-WiGR applies convolutional neural networks (CNN) and long short-term memory (LSTM) neural networks as the basic model for gesture recognition to extract spatial and temporal features. Combined with the meta learning training mechanism, the approach dynamically adjusts the learning rate and meta learning rate in training process adaptively, and optimizes the initial parameters of a basic model for gesture recognition, only using a few samples and several iterations to adapt to new domain. In the experiments, we validate the approach under a variety of scenarios. The results show that ML-WiGR can achieve comparable performance against existing approaches with only a small number of samples for training in cross domains.
Forced Resonance Orbit Analysis of Binary Asteroid System
Authors: Qian Ying-Jing , Zong Kai , Yang Xiao-Dong , Si Zhen , Gao Feng 
Published: October 2021

Abstract
The solar radiation pressure becomes one of the major perturbations to orbits in the study of binary asteroid system, since asteroids have relatively weak gravity fields. In this paper, based on the idea of treating the solar radiation pressure as periodic external excitation, one novel family of orbits due to primary resonance and another novel family of orbits due to both primary resonance and internal resonance have been found by the classical perturbation method. The two types of steady-state orbits due to external resonance with different area-to-mass ratios have been determined and discussed by the frequency-response equations. Five binary asteroid systems, 283 Emma-S/2003 (283) 1, 22 Kalliope-Linus, 31 Euphrosyne-S/2019 (31) 1, 2006 Polonskaya-S/2005 (2006) 1 and 4029 Bridges have been taken as examples to show the validity of the proposed mechanism in the explanation of orbits formation due to resonance.
Developent and Application of Hybrid Method to Inhomogeneous Geology for Curtain Grouting -Case Study in Sedimentary Rock with Fold Movement for Nam Ngiep 1 Hydropower Project in Lao PDR-
Authors: Yoshizu Yoichi , Nakamura Kazuo , Kawata Tatsuya , Fujii Takahiro , Tsutsui Shoji 
Published: October 2021

Abstract
Curtain grouting for dam foundation treatment is one of the most crucial work items in dam construction to secure the impermeability of the foundation rock. Some decades ago, the Grouting Intensity Number (GIN) Method developed in Europe has been frequently applied to relatively simple geotechnical structures. On the other hand, the Conventional Method, which requires phased mix proportion and water pressure tests through a sequence of the works, is as yet reliable for inhomogeneous geology. This paper presents the development of a modified curtain grouting method and its application to the Nam Ngiep 1 Hydropower Project in Lao PDR, which has an inhomogeneous geology of sedimentary rock with weak layers affected by fold movement. The method has been dubbed as “hybrid” because it garners both the economical superiority of the GIN Method in that it enables the use of a single mix proportion, and the technical superiority of the Conventional Method in that the individual design pressure in each stage is based on water pressure tests.
Forward Osmosis: An Approach to Reclaim Dairy Waste Stream Whey
Authors: Agrawal Vibha , Sarode Dilip , Mogha Saransh , Honmane Bharat 
Published: October 2021

Abstract
Recognizing the issues with conventional water resources and stricter wastewater effluent disposal standards, the treatment and recovery from wastewater are gaining impetus. The dairy industry consumes a substantial amount of water and generates a massive quantity of wastewater annually. Whey, which is about 94% water, is a waste stream produced in the dairy industry during the manufacture of cheese, paneer, yogurt, etc. Although various wastewater treatment technologies are available in the market, membrane technologies are considered the most advanced and reliable ones, but they are expensive. In recent years, Forward Osmosis (FO) is looked upon as a potential alternative to these costly and energy intensive pressure driven membrane processes. FO works on the principle of natural osmotic pressure where energy is just required to lift the solutions. The present lab-scale study investigates the partial reclamation of water from whey using FO technology. The Continuous Single Pass (CSP) and Recirculation mode (RC) study is conducted using high osmotic pressure (π = 375 bar at 298K) saturated aqueous(aq.) NaCl as the draw solution. The aq. NaCl solution is a potential brine stream in the dairy industry and finds applications in the manufacture of paneer, butter, cheese and ice cream eliminating the need for draw regeneration. The back diffusion study of the Hollow Fibre Forward Osmosis (HFFO) membrane revealed about 0.82% back diffusion of solute. The maximum water recovery of ~ 56% is achieved in CSP mode while 57.6% is achieved for RC mode with Feed/Draw ratio of 4.5:1. For F/D of 10:1, the maximum permeate flux of ~ 8.7 kg m− 2 h− 1 is observed for the CSP mode of operation for 10 minutes of study. Thus, FO is an efficient membrane technique that eliminates the need for draw regeneration and can be applied in the dairy industry.
Patients Undergoing Multiple 18F-FDG PET/CT Scans: 11-Year Study At A High-Capacity Center
Authors: AbuQbeitah Mohammad , Demir Mustafa , Sönmezoğlu Kerim , Sayman Haluk , Kabasakal Levent , Sager Sait , Asa Sertaç , Uslu-Beşli Lebriz , Rehani Madan 
Published: October 2021

Abstract
Purpose

To assess frequency, clinical indications, and cumulative effective dose (CED) of patients undergoing multiple 18F-FDG PET/CT imaging.
Methods

Retrospective analysis of 18F-FDG PET/CT scans performed at a University hospital for 11 years was done. Effective dose was computed from activity administered and dose-length-product.
Results

A total of 55,424 18F-FDG PET/CT scans were performed in 32,658 patients. The average injected activity was 421 MBq and median 417 MBq. 24.2% of the patients were scanned 2-5 times in a year, 16.7% of them being unique patients (not counted as separate patient in different years). The maximum PET/CT scans in a year was five. 23571 (72.2 %) patients underwent a single 18F-FDG PET/CT scan, while 9087 (27.8%) unique patients underwent 2 - 23 scans during 11 years. 82% of the scanned patients had malignant disease, 2.4% among the patients with ≥ 2 18F-FDG PET/CT scans in a year were with non-malignant indications. 1.4% of patients received CED ≥100 mSv in one year from multiple 18F-FDG PET/CT scans and 0.8% of them received ≥ 100 mSv in a year more than one time, the CED of 27.8% (9087 patients) who underwent 2 to 23 18F-FDG PET/CT scans over 11-years ranged from 38 to 575 mSv (median: 271 mSv).
Conclusion

This first and largest ever study covering analysis of 11-years’ data of 18F-FDG PET/CT patients showed that a sizeable number of patients, largely (82%) with malignant disease undergo recurrent imaging during one year and non-ignorable fraction exceed 100 mSv in one year.
Effects of One-day e-learning Education on Perinatal Psychological Support Among Midwives: a Randomised Controlled Study
Authors: Shinohara Eriko , Ohashi Yukiko , Hada Ayako , Usui Yuriko 
Published: October 2021

Abstract
Background: Although midwives are expected to play a key role for psychological support throughout perinatal periods, their educational chances are limited. Versatile teaching strategies such as e-learning may be promising in expanding education. The objective of our study was to clarify the effects of an e-learning educational programme on midwives’ empathic communication skills.Methods: From April 2019 to September 2019, a randomised controlled trial of a one-day e-learning educational programme on perinatal psychological issues (both perinatal mental health assessment and empathic communication) was conducted to improve empathic communication skills of midwives. Two types of measurements (paper-and-pencil multiple-choice test and video-viewing tests of simulated patient) were used to measure the competency of empathic communication skills.Results: Participants (N = 115) were randomly allocated to two groups (Intervention: n = 58, Control: n = 57). The intervention group was at a significantly higher level for both post-tests of empathic communication skills compared with the control group. Both intervention and control groups showed improvements in acquiring knowledge about perinatal mental health assessments.Conclusions: The results of our study show that a one-day e-learning programme helped improve the midwives' empathic communications skills. Therefore, an effective one-day e-learning educational programme of perinatal mental health will expand opportunity to learn about empathic communication skills for midwives.Trial registrations: UMIN000036052
Current Status of Outpatient Parenteral Antimicrobial Therapy (OPAT) At a University-Affiliated Acute-Care Hospital in The Republic of Korea
Authors: Heo Eunjeong , Choi Yoonhee , Kim Hyung-sook , Namgung Hyung Wook , Lee Eunsook , Lee Euni , Lee Ju-Yeun , Jung Jong Tak , Kim Eu Suk , Kim Hong Bin , Song Kyoung-Ho 
Published: October 2021

Abstract
Objectives

The aim of this study was to describe current status of outpatient parenteral antimicrobial therapy (OPAT) at a tertiary care hospital in the Republic of Korea.
Methods

This retrospective study was conducted on outpatients and referral patients who had a prescription of parenteral antibiotics from July to December 2019. We reviewed the prescribed antimicrobials, the indication of antimicrobial therapy, where patients administered antimicrobial injection and management of pre- and post- prescriptions.
Results

Of the 577 episodes included in this study, 399 (69.2%) were delivered by referral model, 178 (30.8%) by outpatient model. About 70% of OPATs were prescribed in the pulmonology, infectious diseases, orthopedics, gastroenterology, and hematology departments. Five antibiotics (ertapenem (26.0%), ceftriaxone (12.8%), kanamycin (11.8%), amikacin (10.1%), and cefazolin (8.5%)) accounted for 69.2% of the total OPATs. Urinary tract infections (27.3%), respiratory infections (20.8%), and intra-abdominal infections (15.9%) are the most frequent indications of OPAT. After prescription, there were 295 (73.9%) follow-up visits in referral model and 150 (84.3%) in outpatient model (p<0.05). Laboratory tests necessary for monitoring were totally performed in 274 (47.5%).
Conclusions

We found that significant number of OPAT was prescribed, follow-up visits were not performed in about a quarter of episodes, and laboratory monitoring was not fully conducted in more than half of the cases. Therefore, it is necessary to establish an appropriate management program for OPAT. Considering limited resources and the distribution of OPAT prescriptions, it may be effective to select frequently used antibiotics or frequently prescribed departments and start the program for them.
Observation of a Floquet symmetry-protected topological phase with superconducting qubits
Authors: Deng Dong-Ling , Zhang Xu , Jiang Wenjie , Deng Jinfeng , Wang Ke , Chen Jiachen , Zhang Pengfei , Ren Wenhui , Dong Hang , Zhu Xuhao , Gao Yu , Jin Feitong , Guo Qiujiang , Li Hekang , Song Chao , Gorshkov Alexey , Iadecola Thomas , Liu Fangli , Gong Zhexuan , Wang Zhen , Wang Haohua 
Published: October 2021

Abstract
Quantum many-body systems away from equilibrium host a rich
variety of exotic phenomena that are forbidden by equilibrium thermodynamics. A prominent example is that of discrete time crystals [1-8], where time translational symmetry is spontaneously broken in periodically driven systems. Pioneering experiments have observed signatures of time crystalline phases with trapped ions [9,10], spins in nitrogen-vacancy centers [11-13], ultracold atoms [14,15], solid spin ensembles [16,17], and superconducting qubits [18-20]. Here, we report the observation of a distinct type of intrinsically non-equilibrium state of matter, a Floquet symmetry-protected topological phase, which is implemented through digital quantum simulation with an array of programmable superconducting qubits. Unlike the discrete time crystals reported in previous experiments, where spontaneous breaking of the discrete time translational symmetry occurs for local observables throughout the whole system, the Floquet symmetry-protected topological phase observed in our experiment breaks the time translational symmetry only at the boundaries and has trivial dynamics in the bulk. More concretely, we observe robust long-lived temporal correlations and sub-harmonic temporal response for the edge spins over up to 40 driving cycles using a circuit whose depth exceeds 240. We demonstrate that the sub-harmonic response is independent of whether the initial states are random product states or symmetry-protected topological states, and experimentally map out the phase boundary between the time crystalline and thermal phases. Our work paves the way to exploring novel non-equilibrium phases of matter emerging from the interplay between topology and localization as well as periodic driving, with current noisy intermediate-scale quantum processors [21].
Targeted Delivery of Intranasally Administered Cyclovirobuxine D Liposomes to Brain for Treatment Cerebral Ischemia-Reperfusion Injury via Anti-oxidative Stress and Activating Autophagy
Authors: Liu Tuo , Xiao Wen , Yang Fang , Liu Chang , Zhang Jianing , Li Tongming , Chen Zhilian , Yu Yang 
Published: October 2021

Abstract
Background: The lack of effective therapy mandates development of treatment for cerebral ischemia-reperfusion injury (CIRI). The previous study suggested that CVBD encapsulated in Angiopep-conjugated Polysorbate 80-Coated Liposomes showed a better brain targeting by intranasal administration. Therefore, this study focused on the protection and mechanism of CVBD brain-targeted liposomes in treating CIRI.Methods: The CIRI rat model was induced by MCAO. Pharmacological evaluation was assessed in vivo by general indexs, neurobehavioral scores, triphenyl tetrazolium chloride (TTC) staining, histopathological staining (HE staining and Nissl staining), small animal magnetic resonance imaging, biochemical assay and Western blot. Then, the protective effect of CVBD liposomes on OGD/R-injured HT22 cell was investigated by cell fusion degree, cell proliferation curve and cell viability. OGD/R-injured HT22 cell was infected by mRFP-GFP-LC3 adenovirus. The autophagosome and autophagy flow were observed by laser confocal microscopy, and autophagy-related protein expressions (LC3, p62 and Beclin 1) were analyzed by Western blot. Meanwhile, the classic autophagy inhibitor, chloroquine, was used to explore the autophagy- regulated mechanism of CVBD brain-targeted liposomes in treating CIRI. Results: In rat model of CIRI, CVBD liposomes alleviated pathological damage of brain. In cell model of oxygen and glucose deprivation/re-oxygenation, CVBD liposomes increased cell viability and decreased ROS level. CVBD liposomes improved oxidative stress protein expressions and activated autophagy in vitro. Furthermore, CVBD liposomes reversed the decrease of cell viability, increase of ROS level, and reduction of protein expressions associated to anti-oxidative stress and autophagy induced by chloroquine. Conclusions: Therefore, CVBD liposomes inhibited CIRI via regulating oxidative stress and enhancing autophagy level in vivo and in vitro, showing a great potential in treating CIRI in clinic.
Caenorhabditis Elegans ETR-1/CELF Has Broad Effects on the Muscle Cell Transcriptome, Including Genes That Regulate Translation and Neuroblast Migration
Authors: Ochs Matthew , McWhirter Rebecca , Unckless Robert , III David Miller , Lundquist Erik 
Published: October 2021

Abstract
Migration of neuroblasts and neurons from their birthplace is central to the formation of neural circuits and networks. ETR-1 is the Caenorhabditis elegans homolog of the CELF1 (CUGBP, ELAV-like family 1) RNA-processing factor involved in neuromuscular disorders. etr-1 regulates body wall muscle differentiation. Our previous work showed that etr-1 in muscle has a non-autonomous role in neuronal migration, suggesting that ETR-1 is involved in the production of a signal emanating from body wall muscle that controls neuroblast migration and that interacts with Wnt signaling. etr-1 is extensively alternatively-spliced, and we identified the viable etr-1(lq61) mutant, caused by a stop codon in alternatively-spliced exon 8 and only affecting etr-1 isoforms containing exon 8. We took advantage of viable etr-1(lq61) to identify potential RNA targets of ETR-1 in body wall muscle using a combination of fluorescence activated cell sorting (FACS) of body wall muscles from wild-type and etr-1(lq61) and subsequent RNA-seq. This analysis revealed genes whose splicing and transcript levels were controlled by ETR-1 exon 8 isoforms, and represented a broad spectrum of genes involved in muscle differentiation, myofilament lattice structure, and physiology. Genes with transcripts underrepresented in etr-1(lq61) included those involved in ribosome function and translation, similar to potential CELF1 targets identified in chick cardiomyocytes. This suggests that at least some targets of ETR-1 might be conserved in vertebrates, and that ETR-1 might generally stimulate translation in muscles. As proof-of-principle, a functional analysis of a subset of ETR-1 targets revealed genes involved in AQR and PQR neuronal migration. One such gene, lev-11/tropomyosin, requires ETR-1 for alternative splicing, and another, unc-52/perlecan, requires ETR-1 for the production of long isoforms containing 3’ exons. In sum, these studies identified gene targets of ETR-1/CELF1 in muscles, which included genes involved in muscle development and physiology, and genes with novel roles in neuronal migration.