bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of neutrophilia as a prognostic factor in dogs with multicentric lymphoma treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone–based chemotherapy protocol
Authors: Veluvolu Sridhar , Pellin MacKenzie , Vos Nathaniel 
Published: August 2021

Abstract

OBJECTIVE
To determine whether, in dogs with naïve multicentric lymphoma, neutrophilia at the time of initial diagnosis was associated with progression-free survival time (PFST) or overall response rate (ie, percentage of dogs with a complete or partial remission) and whether the initial neutrophil-to-lymphocyte ratio was associated with PFST.

ANIMALS
30 dogs with multicentric lymphoma and neutrophilia (including 16 treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP]–based protocol) and 37 historical control dogs without neutrophilia treated with a CHOP-based protocol.

PROCEDURES
Medical records were reviewed, and PFSTs and responses were documented.

RESULTS
Median PFST for the 16 dogs with neutrophilia treated with a CHOP-based protocol (70 days; range, 0 to 296 days) was significantly shorter than that for the 37 control dogs without neutrophilia (184.5 days; range, 23 to 503 days), and the overall response rate for dogs with neutrophilia (12/16 [75%]) was significantly lower than the rate for dogs without neutrophilia (36/37 [97%]). However, when all dogs in the study and control populations were considered together, the neutrophil-to-lymphocyte ratio at the time of diagnosis was not significantly associated with PFST.

CONCLUSIONS AND CLINICAL RELEVANCE
Results suggested that neutrophilia at the time of initial diagnosis may suggest a poorer prognosis in dogs with multicentric lymphoma. Prospective investigation into the role of neutrophils in the peripheral circulation and tumor microenvironment of cancer-bearing patients is warranted.
PENERAPAN METODE BERMAIN PERAN MAKRO TERHADAP KEMAMPUAN BERBICARA
Authors: Nirwana Nirwana 
Published: August 2021

Effect of role playing macro methods on children's speaking ability in group B in Nurul Rohmah Bekasi. This research is motivated by the lack of ability to speak children. This is because the method used in the learning process is more likely to use conventional methods. The selection of methods to role playing macro so that children can be motivated and interested in learning and can stimulate the ability to speak children. The population in this study were all children of group B in kindergarten Nurul Rohmah while the study sample was B3 group 11 children for the experimental group and B1 group 11 children for the control group. Data collection techniques through test techniques, and observation. Data analysis techniques used were descriptive statistical analysis and nonparametric statistical analysis. Based on the results of the Wilcoxon test calculation, the calculated T value is 66 and T table 11 then the results obtained T count (66)> T table (11) H1 is accepted and Ho is rejected means that there is an effect of role playing macro methods on children's speaking ability. Whereas the calculated Z value obtained is 2.93 and 1.645 table Z then the result of Z arithmetic (2.93)> Z table (1.645) H1 is accepted and Ho is rejected which means that there is an effect of role playing macro method on children's speaking ability. These results indicate that there is a change in the value of the child's speaking ability before and after getting learning based on the role playing macro method.
Estimation of copolymerization reactivity ratios in the Berkson error regression model
Authors: Тимофеева Анастасия Юрьевна 
Published: August 2021

Рассматривается проблема оценки относительной активности мономеров на основе дифференциального уравнения сополимеризации. Обосновано включение в модель погрешности измерения входного признака в виде ошибки Берксона. Предложен алгоритм одновременного оценивания констант сополимеризации и дисперсий ошибок с помощью метода максимального правдоподобия. На примере сополимеризации виниловых эфиров произведено сравнение разных методов оценивания констант сополимеризации. Показано, что метод на основе симметричных уравнений дает некорректные результаты. Результаты оценивания с помощью предложенного алгоритма наиболее близки к оценкам, полученным по нелинейному методу наименьших квадратов
Purpose. The purpose of this paper is to study methods for estimating copolymerization reactivity ratios based on the differential composition equation. Methodology. Most estimation methods reduce the differential composition equation to a linear form. They are based on the least squares method and do not take into account the measurement error in the input variable. Therefore they lead to statistically incorrect results. When analyzing the problem on the basis of the error-in-variables model in the classical case, additional information is required to determine the magnitude of the errors in measuring the concentration of monomers in the mixture and in the copolymer. Inclusion of the measurement error in the input variable into the model as the Berkson error is more consistent with the actual conditions of the experiments. It allows simultaneous estimating both the reactivity ratios and the variances of measurement errors using the maximum likelihood method. Results. The algorithm have been developed for estimating reactivity ratios with no additional information. The empirical study of estimation methods has been carried out using the example of copolymerization of vinyl esters. Findings. It is shown that the method based on symmetric equations gives incorrect results. Estimation results using the proposed algorithm are closest to the estimates obtained by the nonlinear least squares method
The modification of the singular spectral analysis basic method for improving the accuracy of forecasting the irregularity of the Earth rotation
Authors: Гречкосеев Александр Кузьмич , Толстиков Александр Сергеевич , Тиссен Виктор Мартынович , Карманов Виталий Сергеевич , Ваганова Анна Игоревна 
Published: August 2021

Растущие потребности в точности координатно-временных определений со стороны многих прикладных наук о Земле и практических задач приводят к необходимости постоянного совершенствования средств и методов определения и прогнозирования параметров вращения Земли. Параметр “всемирное время”, характеризующий фазу вращения Земли, в наибольшей степени среди других влияет на точность координатно-временных определений. В данной статье приводится описание применения метода сингулярного спектрального анализа к прогнозированию временных рядов параметров вращения Земли. Предлагается модификация базового метода, направленная на повышение точности прогноза. Выполнены сравнительные оценки точности прогнозов всемирного времени, рассчитанных методом сингулярного спектрального анализа, с аналогичными прогнозами Международной службы вращения Земли. Показана целесообразность применения метода сингулярного спектрального анализа для прогнозирования на интервалы более 50 дней
Growing demand for accuracy of coordinate-time determinations from both many applied Earth sciences and practical problems requires the continuous improvement of means and methods for determining and predicting the parameters of the Earth rotation. Parameter “World time” characterizes phase of the Earth’s rotation and mostly affects the accuracy of coordinate-time determinations. This article describes application of method of singular spectral analysis for forecasting the time series of the Earth’s rotation parameters. We propose modification of basic method, which aims at increasing forecast accuracy. We made comparative estimates for accuracy of world time forecasts calculated by the method of singular spectral analysis with similar forecasts by the International Earth Rotation Service. The expediency of using the method of singular spectral analysis for predicting intervals of more than 50 days is shown
A finite difference analogue of the “mean field” equilibrium problem
Authors: Корниенко Виктория Сергеевна , Шайдуров Владимир Викторович , Карепова Евгения Дмитриевна 
Published: August 2021

Представлен конечно-разностный аналог дифференциальной задачи, сформулированной в терминах теории “игр среднего поля” (mean field games). Задачи оптимизации такого типа формулируются как связанные системы параболических дифференциальных уравнений в частных производных типа Фоккера - Планка и Гамильтона - Якоби - Беллмана. Предложенный конечно-разностный аналог обладает основными свойствами оптимизационной дифференциальной задачи непосредственно на дискретном уровне. В итоге он может служить как приближение, сходящееся к исходной дифференциальной задаче при стремлении шагов дискретизации к нулю, так и как самостоятельная оптимизационная задача с конечным числом участников. Для предложенного аналога построен алгоритм монотонной минимизации функционала стоимости, проиллюстрированный на модельной экономической задаче
In most forecasting problems, overstating or understating forecast leads to various losses. Traditionally, in the theory of “mean field games”, the functional responsible for the costs of implementing the interaction of the continuum of agents between each other is supposed to be dependent on the squared function of control of the system. Since additional external factors can influence the player’s strategy, the control function of a dynamic system is more complex. Therefore, the purpose of this article is to develop a computational algorithm applicable for more general set of control functions. As a research method, a computational experiment and proof of the stability of the constructed computational scheme are used in this study. As a result, the numerical algorithm was applied on the problem of economic interaction in the presence of alternative resources. We consider the model, in which a continuum of consumer agents consists of households deciding on heating, having a choice between the cost of installing and maintaining the thermal insulation or the additional cost of electricity. In the framework of the problem, the convergence of the method is numerically demonstrated. Conclusions. The article considers a model of the strategic interaction of continuum of agents, the interaction of which is determined by a coupled differential equations, namely, the Fokker - Planck and the Hamilton - Jacobi - Bellman one. To approximate the differential problem, difference schemes with a semi-Lagrangian approximation are used, which give a direct rule for minimizing the cost functional
Features of BIM-model preparation for photorealistic interactive visualization in virtual and augmented reality
Authors: Згода Юрий Николаевич , Семенов Алексей Александрович , Вагер Борис Георгиевич 
Published: August 2021

Описан высокоэффективный алгоритм экспорта BIM-моделей из BIM-пакета Autodesk Revit с целью построения интерактивной визуализации в виртуальной и дополненной реальности. Для демонстрации эффективности алгоритма выполнена его апробация на информационной модели с высокой степенью детализации. Проведен сравнительный анализ с различными программными комплексами, автоматизирующими экспорт BIM-моделей
Purpose: built-in tools of software packages, such as Autodesk Revit or Renga do not allow rendering realistic BIM-model. Visualization tools of various graphical packages (Autodesk 3ds Max, Blender, Cinema 4D etc.) are mostly using ray tracing, which makes it almost impossible to change the camera angle, geometry materials, lighting parameters etc. in real-time. Therefore, an interactive BIM-model visualization is needed. Such visualization achieves its maximum efficiency when virtual and augmented reality technologies are employed, which allow studying the designed object in volume but requires preliminary processing for model optimization. The purpose of this work is the development of an algorithm for preparation of BIM-model for interactive visualization in virtual and augmented reality. Methodology: processing of BIM-models developed in BIM-modelling software package Autodesk Revit is considered (but main concepts could be applied to other BIM-modelling software packages). Autodesk 3ds Max was selected for model’s geometry processing. Various features of BIM-model export were examined, as well as available ways for optimization of geometry of a building, BIMmodel component structuring and material management. A literature on the subject of the study was analyzed. Findings: a universal algorithm has been developed allowing, on the basis of the information model of the building, in the shortest possible time to prepare a highly optimized 3D model, ready for interactive visualization Value: the developed algorithm can be applied to a BIM-model of any complexity. High level of model optimization allows performing realistic visualization with various interactive components thereby increasing overall realism of interactive visualization
Usage of composite kernel in the SPH method for simulating the movement of granular materials
Authors: Потапов Игорь Иванович , Решетникова Ольга Владимировна 
Published: August 2021

В работе для моделирования движения сыпучей среды используется метод сглаженных частиц. Для аппроксимации искомых функций предложено новое составное ядро малой связности. Основой для разработки ядра послужило требование к условию о сохранении плотности единичной SPH-частицы. Выполнение данного условия позволяет правильно моделировать поле плотности на границах расчетной области, а также в случаях структурных изменений каркаса гранулированных частиц сыпучей среды. Из анализа решения задачи гидростатики методом SPH получена оценка значения масштаба сглаживающей длины ядра для двумерного случая. Выполнен расчет процесса обрушения гранулированного “столба” и проведено сравнение полученных численных результатов моделирования с экспериментальными данными.
The purpose of the study is to improve the practice of the SPH methodology which is applied for modelling of movement in the various media. The basis of the SPH-approximation of the function fields is formed by the forms of the smoothing kernel and its derivatives. Popular forms of smoothing kernels are characterized by the presence of significant fatal approximation errors when modelling granular media. Methodology. The state of granular medium is described by the classical motion and mass conservation equations. Each granule of the medium corresponds to a separate SPH particle. To approximate the density and pressure fields in the SPH particle, a new combination of the smoothing core and its first derivative forms is proposed. Results. The proposed new composite core fulfills the conditions of mass conservation and density recovery in the particle during SPH modeling. It is shown that the new composite core is characterized by a minimum error of pressure gradient approximation - about 2%. A new estimate for the velocity of propagation of an elastic wave in a medium, sufficient to obtain a correct numerical solution, is proposed. A comparative analysis of the obtained solutions with experimental data is made. Findings. The proposed composite shape of the smoothing kernel allows correct simulation of the motion of a granular medium by the SPH method. Its compactness (unit smoothing radius and unit smoothing length) makes it possible to correctly reconstruct the density field at the boundaries of the computational domain and in cases of structural changes in the framework of the granular medium. The numerical solution of the problem of the collapse of a column of granules obtained using the proposed composite core shows good agreement with experimental data.
Cloud technologies for development of geographically distributed computational and analytical Geological environment
Authors: Ерёменко Виталий Сергеевич , Наумова Вера Викторовна , Загуменнов Алексей Андреевич , Булов Станислав Владимирович 
Published: August 2021

Описываются подходы к организации единого рабочего пространства исследователя для обработки геологической информации. Предложены подходы по взаимодействию с внешними территориально распределенными сервисами обработки и анализа геологических данных на основе WPS-платформы и по организации интегральной платформы для доступа к интерактивным облачным сервисам обработки геологических данных. Приводятся примеры облачных сервисов и платформ и сравниваются их основные характеристики. Описывается программная реализация предложенных подходов в рамках разрабатываемой информационноаналитической системы GeologyScience.ru. Приводится общая архитектура системы, и кратко описывается каждый из ее модулей. Описываются внешние сервисы, интегрированные в разрабатываемую платформу.
The purpose of the study is to create an approach for organization of unified workspace for geological data research and processing. The study proposes approaches for organization of interaction with external geographically distributed processing and analytical services of geological data based on WPS platforms. Аn approach for integral platform organization providing access to interactive cloud processing of geological data is proposed. It connects the users with modern methods of data processing and analysis. A brief description of existing cloud services and platforms and comparison of their basic features is presented. Various groups of cloud services are described depending on the type of services provided to the user. Software implementation of approaches proposed within developing informational and analytical system GeologyScience.ru is addressed. The general architecture of the system and author’s modules developed including technological solutions used are described. A brief review of the services integrated into the platform being developed now is given. The use of the developed platform for processing and analyzing of geological data allows further expanding of capabilities of information-analytical environment developers to support scientific research.
On splitting for cubic spline wavelets with four zero moments on an interval
Authors: Шумилов Борис Михайлович 
Published: August 2021

В пространстве кубических сплайнов построены вейвлеты, удовлетворяющие однородным граничным условиям Дирихле и обнулению первых четырех моментов. Получены неявные соотношения, связывающие сплайн-коэффициенты разложения на начальном уровне со сплайн-коэффициентами и вейвлет-коэффициентами на вложенном уровне ленточной системой линейных алгебраических уравнений с невырожденной матрицей. После расщепления на четные и нечетные уравнения матрица преобразования имеет пять (вместо трех в случае двух нулевых моментов) диагоналей. Доказано наличие строгого диагонального доминирования по столбцам. Для сравнения использованы вейвлеты с двумя нулевыми моментами и интерполяционные кубические сплайновые вейвлеты. Результаты численных экспериментов показывают, что схема с четырьмя нулевыми моментами точнее при аппроксимации функций, но грубее при аппроксимации второй производной.
The article examines the problem of constructing a splitting algorithm for cubic spline wavelets. First, a cubic spline space is constructed for splines with homogeneous Dirichlet boundary conditions. Then, using the first four zero moments, the corresponding wavelet space is constructed. The resulting space consists of cubic spline wavelets that satisfy the orthogonality conditions for all thirddegree polynomials. The originality of the research lies in obtaining implicit relations connecting the coefficients of the spline expansion at the initial level with the spline coefficients and wavelet coefficients at the embedded level by a band system of linear algebraic equations with a nondegenerate matrix. Excluding the even rows of the system, the resulting transformation algorithm is obtained as a solution to a sequence of band systems of linear algebraic equations with five (instead of three in the case of two zero moments) diagonals. The presence of strict diagonal dominance over the columns is proved, which confirms the stability of the computational process. For comparison, we adopt the results of calculations using wavelets orthogonal to first-degree polynomials and interpolating cubic spline wavelets with the property of the best mean-square approximation of the second derivative of the function being approximated. The results of numerical experiments show that the scheme with four zero moments is more accurate in the approximation of functions, but becomes inferior in accuracy to the approximation of the second derivative.
Application of Apache Big Data technologies for the problems of climate monitoring
Authors: Золотов Сергей Юрьевич , Турчановский Игорь Юрьевич 
Published: August 2021

Описан эксперимент по использованию технологий Apache Big Data в исследованиях климатических систем. В ходе эксперимента реализовано четыре варианта решения тестовой задачи. Ускорение расчетов с помощью технологий Apache Big Data вполне достижимо, и наиболее эффективный способ для этого найден в четвертом варианте решения тестовой задачи. Суть найденного решения сводится к преобразованию исходных наборов данных к формату, подходящему для хранения в распределенной файловой системе и применения технологи Spark SQL из стека Apache Big Data для параллельной обработки данных на вычислительных кластерах.
The core of the Apache Big Data stack consists of two technologies: Apache Hadoop for organizing distributed file storages of unlimited capacity and Apache Spark for organizing parallel computing on computing clusters. The combination of Apache Spark and Apache Hadoop is fully applicable for creating big data processing systems. The main idea implemented by Spark is dividing data into separate parts (partitions) and processing these parts in memory of many computers connected within a network. Data is sent only when needed, and Spark automatically detects when the exchange will take place. For testing, we chose the problem of calculating the monthly, annual, and seasonal trends in the temperature of the atmosphere of our planet for the period from 1960 to 2010 according to the NCEP/NCAR and JRA-55 reanalysis data. During the experiment, four variants of solving the test problem were implemented. The first variant represents the simplest implementation without parallelism. The second implementation variant assumes parallel reading of data from the local file system, aggregation, and calculation of trends. The third variant was the calculation of a test problem on a two-node cluster. NCEP and JRA-55 reanalysis files were placed in their original format in the Hadoop storage (HDFS), which combines the disk subsystems of two computers. The disadvantage of this variant is loading all reanalysis files completely into the random access memory of the workflow. The solution proposed in the fourth variant is to pre-convert the original file format to a form when reading from HDFS is selective, based on the specified parameters.