bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substrate availability regulates the suppressive effects of Canada goldenrod invasion on soil respiration
Authors: Hu Zhiyuan , Zhang Jiaqi , Du Yizhou , Shi Kangwei , Ren Guangqian , Iqbal Babar , Dai Zhicong , Li Jian , Li Guanlin , Du Daolin 
Published: July 2021

AbstractInvasive alien plants not only decrease riparian vegetation diversity but also alter wetland ecosystem carbon processes, especially when they displace the original vegetation. Invasive Canada goldenrod (Solidago canadensis L.) has colonized large areas of disturbed and undisturbed land in southeastern China, yet little is known regarding how it affects soil carbon cycling. To explore the response patterns of soil respiration following S. canadensis invasion and their driving mechanisms, an observational field study and a greenhouse experiment simulating invasion were performed. In the field study, soil respiration was measured weekly from 21th July 2018 to 15th December 2018. In the greenhouse experiment, soil, autotrophic and heterotrophic respiration were measured every 1st and 15th of the month from 15th July 2019 to 15th December 2019. Soil, autotrophic and heterotrophic respiration were measured using a closed-chamber system with the deep gauze collar root exclusion method. Solidago canadensis invasion appeared to decrease the total soil CO2 emissions in both the field study and the greenhouse experiment. The suppressive effects on soil respiration may be attributed to S. canadensis invasion-induced alterations in the quality and quantity of available soil substrate, suggesting that S. canadensis invasion may impact soil carbon cycling via plant-released substrates and by competing for the soil available substrate with native plant and/or soil microbes. These results have substantial implications for estimations of the effects of invasive plants on belowground carbon dynamics and their contribution to the warming world.
Testing for Phases of Dropout Attrition Using Change-Point Hazard Models
Authors: Hochheimer Camille J , Sabo Roy T 
Published: July 2021

Abstract
While web-based surveys are a convenient research tool, the ease of dropping out in the online setting has become a growing issue in ensuring data quality. One theory is that dropout, or attrition, occurs in phases that can be generalized to phases of high dropout and phases of stable use. In order to detect these phases, survey dropout is considered as a time-to-event outcome and tests within change-point hazard models are introduced. Here, we apply the multiple change-point exponential model and extend the single change-point Weibull model to account for multiple change-points. We also introduce a likelihood ratio test to aid in determining the number of distinct phases, using Monte Carlo simulations of the null hypothesis of no attrition phases or change-points against the alternative hypothesis that distinct attrition phases exist (at least one change-point). The performances of these change-point hazard models are compared using both a simulation study and also with application to survey data on patient cancer screening preferences, as well as compared to previous work with discrete models.
Towards a computer-assisted aesthetics of user response
Authors: Armaselu Florentina 
Published: July 2021

AbstractThe article focuses on the analysis of the user as an aesthetic category and proposes a methodology for evaluating user response within a framework that combines theoretical background from different areas, the theory of aesthetic response, psycholinguistics, appraisal theory, dialogism, and affective stylistics, with the application of digital tools for corpus linguistics and sentiment analysis. Four user types were derived from the corpus linguistics analysis referred to as immersed, distant, sceptical, and enthusiastic users. Each type may encompass a certain degree of intentionality and convey an attitude, implying features such as commitment and honesty, objectivity and engagement with the audience, critical reflection and circumspection, openness to technological novelty, and enjoyment. This assumes that the users involved in usability testing are not neutral or undifferentiated informational entities placed in an experimental context but individuals that respond to the same stimuli and express themselves differently in light of psycholinguistic factors and rules of social interaction. On the other hand, the results of sentiment analysis showed that an experiential analysis, centred not only on the artefact but also on the response and the experience it generates, may enable understanding the user as involved in a hermeneutic process of interpretation during his/her interaction with the studied artefact. Given the small scale of the analysed data, the study does not intend to provide evidence for general or definitive statements but formulates and illustrates a set of interpretative hypotheses and methodological directions for further enquiry aiming at developing an ‘aesthetics’ of user response.
The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization
Authors: Yan Kevin Kok-Phen , Obi Ikenna , Sabouri Nasim 
Published: July 2021

Abstract
The identification of G-quadruplex (G4) binding proteins and insights into their mechanism of action are important for understanding the regulatory functions of G4 structures. Here, we performed an unbiased affinity-purification assay coupled with mass spectrometry and identified 30 putative G4 binding proteins from the fission yeast Schizosaccharomyces pombe. Gene ontology analysis of the molecular functions enriched in this pull-down assay included mRNA binding, RNA helicase activity, and translation regulator activity. We focused this study on three of the identified proteins that possessed putative arginine-glycine-glycine (RGG) domains, namely the Stm1 homolog Oga1 and the DEAD box RNA helicases Dbp2 and Ded1. We found that Oga1, Dbp2, and Ded1 bound to both DNA and RNA G4s in vitro. Both Dbp2 and Ded1 bound to G4 structures through the RGG domain located in the C-terminal region of the helicases, and point mutations in this domain weakened the G4 binding properties of the helicases. Dbp2 and Ded1 destabilized less thermostable G4 RNA and DNA structures, and this ability was independent of ATP but dependent on the RGG domain. Our study provides the first evidence that the RGG motifs in DEAD box helicases are necessary for both G4 binding and G4 destabilization.
Intermediate luminosity type Iax supernova 2019muj with narrow absorption lines: Long-lasting radiation associated with a possible bound remnant predicted by the weak deflagration model
Authors: Kawabata Miho , Maeda Keiichi , Yamanaka Masayuki , Nakaoka Tatsuya , Kawabata Koji S , Aoki Kentaro , Anupama G C , Burgaz Umut , Dutta Anirban , Isogai Keisuke , Kino Masaru , Kojiguchi Naoto , Kota Iida , Kumar Brajesh , Kuroda Daisuke , Maehara Hiroyuki , Matsubayashi Kazuya , Morihana Kumiko , Murata Katsuhiro L , Ohshima Tomohito , Otsuka Masaaki , Sahu Devendra K , Singh Avinash , Sugitani Koji , Takahashi Jun , Takagi Kengo 
Published: July 2021

Abstract
We present comprehensive spectroscopic and photometric analyses of the intermediate luminosity type Iax supernova (SN Iax) 2019muj based on multi-band datasets observed through the framework of the OISTER target-of-opportunity program. SN 2019muj exhibits almost identical characteristics to the subluminous SNe Iax 2008ha and 2010ae in terms of the observed spectral features and the light curve evolution at the early phase, except for the peak luminosity. The long-term observations unveil late-time flattening light curves as seen in luminous SN Iax 2014dt. This can be explained by the existence of an inner dense and optically thick component possibly associated with a bound white dwarf remnant left behind after the explosion. We demonstrate that the weak deflagration model with a wide range of explosion parameters can reproduce the late-phase light curves of other SNe Iax. Therefore, we conclude that a common explosion mechanism operates for different subclass SNe Iax.
AUXIN RESPONSE FACTORS 6 and 17 control the flag leaf angle in rice by regulating secondary cell wall biosynthesis of lamina joints
Authors: Huang Guoqiang , Hu Heng , van de Meene Allison , Zhang Jiao , Dong Le , Zheng Shuai , Zhang Fengli , Betts Natalie S. , Liang Wanqi , Bennett Malcolm J. , Persson Staffan , Zhang Dabing 
Published: July 2021

Abstract
Flag leaf angle impacts the photosynthetic capacity of densely grown plants and is thus an important agronomic breeding trait for crop architecture and yield. The hormone auxin plays a key role in regulating this trait, yet the underlying molecular and cellular mechanisms remain unclear. Here, we report that two rice (Oryza sativa) auxin response factors (ARFs), OsARF6 and OsARF17, which are highly expressed in lamina joint tissues, control flag leaf angle in response to auxin. Loss-of-function double osarf6 osarf17 mutants displayed reduced secondary cell wall levels of lamina joint sclerenchymatous cells (Scs), resulting in an exaggerated flag leaf angle and decreased grain yield under dense planting conditions. Mechanical measurements indicated that the mutant lamina joint tissues were too weak to support the weight of the flag leaf blade, resembling the phenotype of the rice increased leaf angle1 (ila1) mutant. We demonstrate that OsARF6 and OsARF17 directly bind to the ILA1 promoter independently and synergistically to activate its expression. In addition, auxin-induced ILA1 expression was dependent on OsARF6 and OsARF17. Collectively, our study reveals a mechanism that integrates auxin signaling with the secondary cell wall composition to determine flag leaf angle, providing breeding targets in rice, and potentially other cereals, for this key trait.
ASSESSMENT OF MEASUREMENT UNCERTAINTY FOR THE MEASUREMENT OF THE QUANTITY PERSONAL DOSE EQUIVALENT HP (10) IN PHOTON FIELDS USING THE GUM FRAMEWORK AND THE MONTE CARLO METHODS: APPLICATION TO GABON RESULTS OBTAINED DURING THE 2018 IAEA REGIONAL INTERCOMPARISON EXERCISE
Authors: Meye P Ondo , Mouandza S Y Loemba , Dallou G B , Omon Y , Bazoma J , Chaley C , Schandorf C , Ben-Bolie G H 
Published: July 2021

Abstract
This paper describes the essential of the “Guide to the expression of Uncertainty in Measurement” Framework (GUMF) Method and Monte Carlo Method (MCM) for propagating uncertainties, with an application to Gabon results obtained during the 2018 International Atomic Energy Agency (IAEA) regional intercomparison exercise. The work has shown that the output quantity Hp (10) follows a lognormal distribution. The study has also shown that although the normal distribution does not best approximate the distribution of the output quantity Hp (10), it has been observed that its estimate, the associated standard uncertainty and the coverage interval determined by GUMF and MCM were close, meaning that the application of the GUMF could still be seen as valid. Finally, the results obtained by the two methods are in agreement with International Commission on Radiological Protection and IAEA requirements for overall accuracy.
Prenatal immune stimulation alters the postnatal acute phase and metabolic responses to an endotoxin challenge in weaned beef heifers,
Authors: Carroll Jeffery A , Burdick Sanchez Nicole C , Broadway Paul R , Silva Gleise M , Ranches Juliana , Warren Julie , Arthington John D , Lancaster Phillip A , Moriel Philipe 
Published: July 2021

AbstractThis study evaluated whether administration of lipopolysaccharide (LPS) at each trimester of gestation would alter the acute phase (APR) and metabolic responses to a postnatal LPS challenge in weaned heifers. Pregnant crossbred multiparous cows (n = 50) were randomized into prenatal immune stimulation (PIS; n = 24; administered 0.1 µg/kg BW LPS subcutaneously at 71 ± 2, 170 ± 2 and 234 ± 2 d of gestation) and saline (CON; n = 26) groups. From these treatment groups, heifer calves (n = 12 PIS and 11 CON) were identified at weaning (244 ± 3 d of age) to receive an LPS challenge. On d 0, heifers were fitted with vaginal temperature (VT) devices, jugular catheters, and moved into individual stalls. On d 1, heifers were challenged i.v. with LPS (0.5 µg/kg BW) at 0 h. Blood samples were collected and sickness behavior scores (SBS) recorded at 0.5 h intervals from −2 to 8 h and at 24 h relative to LPS challenge. Serum was analyzed for cortisol, cytokines, glucose, non-esterified fatty acids (NEFA), and serum urea nitrogen (SUN) concentrations. Baseline VT was lesser in PIS heifers from −11 to −5 h pre-LPS (treatment × time: P &lt; 0.01) compared to the CON; however, the post-LPS VT response did not differ between treatments (P = 0.89). There was a treatment × time interaction (P &lt; 0.01) for SBS with PIS heifers having lesser SBS from 0.5 to 2 h post-LPS compared to CON. There was a treatment × time interaction (P = 0.03) for cortisol with PIS heifers having greater cortisol at 0.5, 3, 3.5, 5.5 and 6.5 h post-LPS compared to CON. There were treatment × time interactions for the post-LPS cytokine responses (P ≤ 0.05). Specifically, PIS heifers had greater TNF-α from 1.5 to 2 h, yet less TNF-α at 3 h than CON (P &lt; 0.01), and PIS heifers had greater IFN-γ from 3.5 to 5.5 h post-LPS than CON (P &lt; 0.01). In contrast, IL-6 was less in PIS than CON heifers from 1.5 to 8 h post-LPS (P &lt; 0.001). Glucose concentrations were greater in PIS heifers at −1 h, but less at 2, 3 and 5.5 h compared to CON (treatment × time: P &lt; 0.01). Serum NEFA concentrations were greater (P = 0.04) in PIS than CON heifers. There was a treatment × time interaction (P &lt; 0.01) for SUN with PIS heifers having greater SUN concentrations at −2, −1.5, 2, 3, 6.5 and 24 h than CON. These data demonstrate that in utero exposure to multiple low doses of endotoxin has lasting physiological and immunological effects when the offspring encounter a similar postnatal immunological insult.
A qualitative exploration of the feasibility of incorporating depression apps into integrated primary care clinics
Authors: Dinkel Danae , Harsh Caspari Jennifer , Fok Louis , Notice Maxine , Johnson David J , Watanabe-Galloway Shinobu , Emerson Margaret 
Published: July 2021

Abstract
The use of mobile applications or “apps” is beginning to be identified as a potential cost-effective tool for treating depression. While the use of mobile apps for health management appears promising, little is known on how to incorporate these tools into integrated primary care settings—especially from the viewpoints of patients and the clinic personnel. The purpose of this study was to explore patient- and clinic-level perceptions of the use of depression self-management apps within an integrated primary care setting. Patients (n = 17), healthcare providers, and staff (n = 15) completed focus groups or semi-structured interviews in-person or via Zoom between January and July 2020. Participants were asked about barriers and facilitators to app use, how to best integrate it into care, and reviewed pre-selected mental health apps. Data were analyzed using a directed content analysis approach. From a patient perspective, features within the app such as notifications, the provision of information, easy navigation, and a chat/support function as well as an ability to share data with their doctor were desirable. Providers and staff identified integration of app data into electronic health records to be able to share data with patients and the healthcare team as well as clear evidence of effectiveness as factors that could facilitate implementation. All participants who reviewed apps identified at least one of them they would be interested in continuing to use. Overall, patients, healthcare providers, and staff believed depression apps could be beneficial for both patients and the clinic.
Ultrasound-guided regional anesthesia in COVID-19 and future pandemics: infection control
Authors: Murata Hiroaki , Vanegas Cristina , Ogami-Takamura Keiko 
Published: July 2021

Purpose of review
Infection control is inherent in ultrasound-guided regional anesthesia practice, because ultrasound transducer and coupling gel can be vectors for pathogen transmission. We reviewed the current standards and recommendations of ultrasound transducer cleaning, disinfection, and safe handling of ultrasound equipment. Based on the available data, we propose a set of practical recommendations applicable to coronavirus disease 2019 (COVID-19) pandemic and future epidemics.

Recent findings
Regional anesthesia is often preferred over general anesthesia for COVID-19 patients. Avoidance of general anesthesia reduces the need for aerosol generating procedures. Administration of ultrasound-guided regional anesthesia and surgery under regional anesthesia in COVID-19 patients requires careful infectious precautions to prevent the viral spread through the use equipment.

Summary
Ultrasound machine, transducer and coupling gel can serve as a vector for transmission of pathogens. In the era of COVID-19 pandemic, standardized strategies are recommended to minimize the risk of spread of COVID-19 to both patients and the healthcare providers.
Antibodies targeting Prostate-Specific Membrane Antigen positive prostate cancer: from diagnostic imaging to theranostics
Authors: Roumeguère Thierry , Aoun Fouad , Albisinni Simone , Mjaess Georges 
Published: July 2021

Purpose of review
Targeting Prostate-Specific Membrane Antigen (PSMA) has paved the way for personalized medicine in prostate cancer (PCa) patients. This review aims to highlight the role of PSMA targeting antibodies in PCa, for diagnostic and therapeutic purposes.

Recent findings
PSMA Positron Emission Tomography/Computed Tomography has been a game changer in the diagnosis of PCa in the recent decade. Two anti-PSMA monoclonal antibodies have been studied in PCa: 7E11-C35 (limited use) and J591. J591 antibody was used for diagnostic purposes coupled with different radionuclides. Most importantly, it was combined to numerous therapeutic radionuclides such as Lutetium-177 (177Lu), Yttrium-90 (90Y), Indium-111 (111In), and Actinium-225 (225Ac). It was also conjugated to drugs forming antibody-drug conjugates (e.g. MLN2704 and PSMA-ADC). These compounds were tested in recent phase I/II clinical trials.

Summary
PSMA targeting antibodies are very promising for further clinical investigation and continue to be a momentous research area, for both imaging and therapeutic settings. Although some clinical trials resulted in unfavorably safety profiles for some antibodies, they validated PSMA as a crucial immunoconjugate target.
Psychometric Comparison of the English and Spanish Western-Hemisphere Versions of the Modified Checklist for Autism in Toddlers—Revised
Authors: DuBay Michaela , Watson Linda R. , Méndez Lucía I. , Rojevic Carolina 
Published: July 2021

ABSTRACT:

Objectives:
Parent-report screening tools for autism spectrum disorder (ASD) are widely used to promote early identification of children with or at risk for ASD. Most screening tools have been developed in English in the United States or United Kingdom; thus, translated versions are needed for use with culturally and linguistically diverse populations. Traditional translation methods include a forward translation, back translation, and review. However, when used in new cultural and linguistic contexts, this “forward-back” approach may have limitations, including differing psychometric properties compared with original instruments. This study presents a psychometric analysis of the forward-back translation methodology of an ASD screening tool.

Methods:
A retrospective chart review design was used to examine Modified Checklist for Autism in Toddlers—Revised (M-CHAT-R; Robins et al.) records from 2974 toddlers. Data were compared between caregivers who completed the original English M-CHAT-R and caregivers who completed its forward-back “Spanish-Western Hemisphere” translation to compare select psychometric properties of the 2 instruments.

Results:
Significant differences were observed between the 2 versions, including a higher overall risk score, higher initial screen-positive rate, and increased likelihood of leaving items blank among Spanish-speaking respondents.

Conclusion:
Traditional translation methods seemed to affect select psychometric properties between translations of the M-CHAT-R. A more rigorous cultural adaptation approach may be necessary to maintain equivalence with the original instrument. Until new rigorous translations are available, it is recommended that language-specific screening tools continue to be used, along with recommended follow-up interviews, to avoid exacerbating existing health disparities.
Resveratrol Confers Protection Against Ischemia/Reperfusion Injury by Increase of Angiotensin (1-7) Expression in a Rat Model of Myocardial Hypertrophy
Authors: Soltan Fahimeh , Esmaili Dahej Mansour , Yadegari Maryam , Moradi Ali , Hafizi Barjin Zeinab , Safari Fatemeh 
Published: July 2021

Abstract:
Left ventricular hypertrophy (LVH) makes the heart vulnerable to ischemia/reperfusion (IR) injury. Angiotensin (Ang) (1-7) is recognized as a cardioprotective peptide. We investigated the effect of polyphenol resveratrol on myocardial IR injury after hypertrophy and examined cardiac content of Ang (1-7) and transcription of its receptor (MasR). Rats were divided into sham-operated, LVH, IR, LVH + IR, and resveratrol + LVH + IR groups. Myocardial hypertrophy and IR models were created by abdominal aortic banding and left coronary artery occlusion, respectively. To evaluate the electrocardiogram parameters and incidence of arrhythmias, electrocardiogram was recorded by subcutaneous leads (lead II). Blood pressure was measured through the left carotid artery. Infarct size was determined by the triphenyl tetrazolium chloride staining. The Ang (1-7) level was evaluated by immunohistochemistry. The Mas receptor mRNA level was assessed by the real-time real time reverse transcription polymerase chain reaction technique. QT-interval duration, infarct size, and incidence of ischemia-induced arrhythmia were significantly higher in the LVH + IR group. However, in the resveratrol-treated group, these parameters were decreased significantly. The cardiac level of Ang (1-7) was decreased in untreated hypertrophied hearts (LVH and LVH + IR groups). Pretreatment with resveratrol normalized the cardiac level of Ang (1-7). The mRNA level of Mas receptor was increased in all of hypertrophied hearts in the presence or absence of resveratrol. Resveratrol can decrease IR injury in rats with LVH. The anti-ischemic effect of resveratrol may be related to the enhancement of Ang (1-7)/MasR axis.
Dual Role of Mitophagy in Cardiovascular Diseases
Authors: Li Yibo , Meng Weizheng , Hou Yaxin , Li Dongxu , Wang Xiulong , Wu Kai , Sun Siyu , Liu Huibing , Li Xuefang , Lin Fei , Zhao Guoan 
Published: July 2021

Abstract:
Mitophagy is involved in the development of various cardiovascular diseases, such as atherosclerosis, heart failure, myocardial ischemia/reperfusion injury, and hypertension. Mitophagy is essential for maintaining intracellular homeostasis and physiological function in most cardiovascular origin cells, such as cardiomyocytes, endothelial cells, and vascular smooth muscle cells. Mitophagy is crucial to ensuring energy supply by selectively removing dysfunctional mitochondria, maintaining a balance in the number of mitochondria in cells, ensuring the integrity of mitochondrial structure and function, maintaining homeostasis, and promoting cell survival. Substantial research has indicated a “dual” effect of mitophagy on cardiac function, with inadequate and increased mitochondrial degradation both likely to influence the progression of cardiovascular disease. This review summarizes the main regulatory pathways of mitophagy and emphasizes that an appropriate amount of mitophagy can prevent endothelial cell injury, vascular smooth muscle cell proliferation, macrophage polarization, and cardiomyocyte apoptosis, avoiding further progression of cardiovascular diseases.