bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Single Session Receptive Music Therapy on Anxiety and Vital Parameters in Hospitalized Covid-19 Patients: A Randomized Controlled Trial.
Authors: Giordano Filippo , Losurdo Antonella , Quaranta Vitaliano , Campobasso Nicla , Daleno Antonio , Carpagnano Elisiana , Gesualdo Loreto , Moschetta Antonio , Brienza Nicola 
Published: October 2021

Abstract
Hospitalized COVID-19 patients are vulnerable to different degrees of stress disorders as well as depression, anxiety and fear. The aim of this study was to evaluate the feasibility of introducing Music therapy (MT) on site with Covid-19 patients and investigating the immediate effects a single session has on anxiety, heart rate (HR), oxygen saturation (O2Sat) and satisfaction compared to standard care. A randomized controlled trial of 40 patients was conducted. Participants were assigned to control group (CG) or the MT group (MG). MG received an individual single session of music therapy in presence. CG received standard care. MG and CG were subjected to identical measurements (pre-during-post) of the parameters STAI-Y, HR and O2Sat. Participants in MG were asked to fill in an optional open-ended question concerning their experience with MT.
Significant difference in anxiety levels between scores in MG and CG (34.50 (23.25 - 40.00) vs 45.00(38, 25 - 54.00); p = 0.000) was observed. MG compared to CG had statistically significantly higher values of O2Sat (97.50 (96.25 - 99.00) versus 96.00 (96.00- 98.00); p = 0.026).
Results show the feasibility of introducing MT as a supporting complementary/non-pharmacological intervention on site in Covid-19 patients. A single session of MT improves O2Sat and can significantly reduce anxiety.
Three-Dimensional Walnut-Like, Hierarchically Zn-MOF Microsphere: One-Pot Synthesis, Characterization And Its Application as a Green Catalyst For The Asymmetric Hantzsch Synthesis of Polyhydroquinolines
Authors: Ramish Sayed Mohammad , Ghorbani-Choghamarani Arash , Mohammadi Masoud 
Published: October 2021

Abstract
A three-dimensional walnut-like, microsphere Zn-based MOFs system was designed and synthesized via hydrothermal reaction of zinc salt with 4,6-diamino-2-pyrimidinethiol as a tridentate ligand. Besides, Zn ions were coordinated to the ligand’s functional groups to give a novel Zn-MOF microsphere material. Afterward, the resultant material was thoroughly characterized by various analysis and physico-chemical methods; including, FT-IR, XRD, TGA, EDX, X-ray mapping, SEM, TEM, and BET analysis. The Zn-MOF microspheres were utilized in the Hantzsch reaction for selective synthesis of asymmetric polyhydroquinolines, using various aromatic aldehydes. Our strategy provides a way for controlled synthesis of the hierarchically nanoporous Zn-MOF microspheres with well-defined morphology, structure, and excellent catalytic properties, resulting in having a promising heterogeneous catalyst for a selective synthesis with good yields in the short reaction time and a low limit of steric hindrance and electronic effects. Besides, the heterogeneity of the catalyst is further tested with hot filtration and also the reusability results point.
Building Global Capacity for COVID-19 Vaccination Through Interactive Virtual Learning
Authors: Goldin Shoshanna , Hood Nancy , Pascutto Alexandre , Bennett Celine , de Lima Ana Carolina Barbosa , Devereaux Nicole , Caric Aleksandra , Rai Karan , Desai Shalini , Lindstrand Ann , Struminger Bruce 
Published: October 2021

Abstract
Background
To support the introduction of the COVID-19 vaccine, the World Health Organization and its partners developed an interactive virtual learning initiative through which vaccination stakeholders could receive the latest guidance, ask questions, and share their experiences. This initiative, implemented between 9 February 2021 and 15 June 2021, included virtual engagement between technical experts and participants during a 15-session interactive webinar series as well as web and SMS-messaging discussions in English and French.
Methods
This article uses a mixed-methods approach to analyze survey data collected following each webinar and a post-series survey conducted after the series had concluded. Participant data was tracked for each session and feedback surveys were conducted after each session to gauge experience quality and content usability. Chi-square tests were used to compare results across professions (health workers, public health practitioners, and other).
Results
The COVID-19 Vaccination: Building Global Capacity webinar series reached participants in 181 countries or 93% of the WHO Member States; 78% of participants were from low-and middle-income countries (LMICs). More than 60% of participants reported using the resources provided during the sessions and 47% reported sharing these resources with colleagues. More than 79% of participants stated that this initiative significantly improved their confidence in preparing for and rolling out COVID-19 vaccinations; an additional 20.3% stated that the initiative “somewhat” improved their confidence. In the post-series survey, 70% of participants reported that they will “definitely use” the knowledge derived from this learning series in their work; an additional 19.7% will “probably use” and 8.6% would “possibly use” this knowledge in their work.
Conclusion
The COVID-19 Vaccination: Building Global Capacity learning initiative used a digital model of dynamic, interactive learning at scale. The initiative enhanced the WHO’s ability to disseminate knowledge, normative guidance, and best practices to COVID-19 vaccination stakeholders in real-time. This approach allowed the WHO to hear the information needs of stakeholders and respond by developing guidance, tools, and trainings to support COVID-19 vaccine introduction. The WHO and its partners can learn from this capacity-building experience and apply best practices for digital interactive learning to other health programmes moving forward.
Investigation of the Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Patients with Neuromyelitis Optica Spectrum Disorders
Authors: SUN Qingli , FAN Dongsheng 
Published: October 2021

Abstract
Background: This study aimed to explore the differences in the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with neuromyelitis optica spectrum disorders (NMOSDs) as well as their relationship with the onset of the diseases.Methods: The clinical data, laboratory findings, and imaging data of patients with NMOSD admitted to Perking University Third Hospital from January 2015 to December 2020 were retrospectively analyzed. Routine blood tests of patients performed within one week of the appearance of new clinical symptoms or imaging lesions were collected to calculate the NLR and PLR. The routine blood test of the patients in remission was performed more than 6 months after the patients stopped hormone use. The NLR and PLR of patients were compared with those of 100 healthy subjects undergoing physical examinations.Results: A total of 55 patients with NMOSD were enrolled. 44 patients with NMOSD were followed up. In patients with NMOSD, the white blood cell (WBC) count, absolute neutrophil count, and NLR were significantly higher than those in patients in remission and the controls, while the absolute lymphocyte count was significantly lower than that in patients in remission and the controls. In patients with NMOSD in remission, there were no statistically significant differences in the WBC count, absolute neutrophil count, absolute lymphocyte count, or NLR compared with the controls. The PLR of patients with NMOSD in the attack stage was significantly higher than that of the controls, while the PLR of patients with NMOSD in remission was not significantly different from that of the attack stage and the controls. There were no statistically significant differences between APQ4 (+) and APQ4 (-) in patients with NMOSD at the attack stage in the WBC count, absolute neutrophil count, absolute lymphocyte count, platelet count, NLR or PLR. ROC analysis of NLR and PLR for the diagnosis of inflammatory changes in NMOSD at the attack stage and controls: The ROC curve was plotted using NLR and PLR as dependent variables. In patients with NMOSD, the AUC was 0.806 for NLR and 0.612 for PLR. ROC analysis of NLR and PLR for the diagnosis of inflammatory changes in NMOSD at the attack stage and remission stage. The AUC was 0.728 for NLR and 0.594 for PLR.Conclusion: Patients with NMOSD had significantly higher WBC counts, absolute neutrophil counts and NLRs, and elevated NLRs were correlated with inflammatory activity in NMOSD.
Health-Promoting Factors Among Students in Higher Education within Health Care and Social Work: A Cross-Sectional Analysis of Baseline Data in a Multicentre Longitudinal Study
Authors: Ahlstrand Inger , Larsson Ingrid , Larsson Margaretha , Ekman Aimée , Hedén Lena , Laakso Katja , Lindmark Ulrika , Nunstedt Håkan , Oxelmark Lena , Pennbrant Sandra , Sundler Annelie J , Hallgren Jenny 
Published: October 2021

Abstract
Background: Educational environments are considered important for strengthening students’ health status and knowledge, which is associated with good educational outcomes. It has been suggested to establish healthy universities based on a salutogenic approach—namely, health promotion. The aim of this study was to describe health-promoting resources and factors among first-semester students in higher education in healthcare and social work.Methods: This cross-sectional study is based on a survey provided to all students in seven healthcare and social work programmes from six universities in southern Sweden. The survey was performed in 2018 using a self-reported, web-based questionnaire focussing on general health and well-being, lifestyle factors and three validated instruments measuring health-promoting factors and processes—the Sense of Coherence (SOC) scale, Salutogenic Health Indicator Scale (SHIS) and Occupational Balance Questionnaire (OBQ).Results: Of 2283 students, 851 completed the survey, where 742 (87.1%) were women; 722 students participated in healthcare programmes, and 129 students participated in social work programmes. Most reported good general health and well-being (88.1% and 83.7%, respectively). The total mean scores for the SOC scale, SHIS and OBQ were 59.09 (SD = 11.78), 44.04 (SD = 9.38) and 26.40 (SD = 7.07), respectively. Well-being and several health-promoting lifestyle factors were related to better general health and higher SOC, SHIS and OBQ scores. Multiple linear and logistic regressions showed that perceived well-being and no sleeping problems significantly predicted higher general health and higher SOC, SHIS and OBQ scores. Being less sedentary and non-smoking habits were significant predictors of higher SOC.Conclusions: Swedish students in higher education within the healthcare and social work sector report good general health and well-being in the first semester, as well as health-promoting resources (i.e. SOC, SHIS and OBQ), and in some aspects, a healthy lifestyle. High-intensity exercise, no sleeping problems and non-smoking seem to be of importance to both general health and health-promotive resources. This study contributes to the health promotive characteristics of students in the healthcare and social work sectors, which is of importance for planning universities with a salutogenic approach.
Albumin Paclitaxel Plus Platinum With or Without Pembrolizumab for Metastatic Primary Pulmonary Lymphoepithelioma-like Carcinoma: a Retrospective Multicenter Study
Authors: Bao Hejing , Ma LingZhen , Lin Xiaoli , Zhang Boshen , Zhang Juan , Peng Guibao , Lin Xiaotong , Fang Yinhua , Bao Hehong , Ma Shudong 
Published: October 2021

Abstract
Objectives

Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), and the first-line therapy for metastatic PPLELC patients remains controversial. The purpose of this study was to investigate the efficacy and safety of immune checkpoint inhibitors(ICIs) combined with chemotherapy(CT) compared with traditional chemotherapy in these patients.
Methods

A total of 168 patients with metastatic PPLELC came from six grade A hospitals from August 2018 to August 2020 were selected. 17 patients were enrolled in the ICI group and received 200mg of Pembrolizumab plus albumin paclitaxel and carboplatin every 3 weeks. 34 patients with chemotherapy alone were assigned to the CT group and received albumin-paclitaxel combined with carboplatin every 3 weeks.
Results

As of June 1, 2021, the median PFS was 14.9 months for ICI group and 6.4 months for CT group [Hazard Ratio (HR), 0.29; 95% confidence interval (CI), 0.15-0.55; P < 0.05]. ORR was 64.7% in ICI group and 35.3% in CT group [HR, 0.65; 95%CI, 0.39-0.90; P=0.047]. The median OS of ICI group was not reached, while that of CT group was 13 months. In the ICI group, there were 8 cases (47.1%) of grade 3 treatment-related adverse reactions and 5 cases (29.4%) of grade 4 treatment-related adverse reactions. In the CT group, there were 9 cases (26.5%) of grade 3 treatment-related adverse reactions and 8 cases (23.5%) grade 4 treatment-related adverse reactions. FBXW7 mutation were negatively and TP53 mutation, MRE11A p.V198S mutation, PTEN p.T319FS mutation were positively correlated with the efficacy of immunotherapy.
Conclusions

In patients with metastatic PPLELC, the efficacy of immune checkpoint inhibitors combined with chemotherapy was significantly better than that of chemotherapy alone, and adverse reactions were acceptable.
Economic Benefit of Coastal ‘Blue Carbon’ Stocks in Moroccan Lagoon Ecosystem: A Case Study From Moulay Bousselham lagoon
Authors: kacem Hicham Ait , Bouroubi Yacine , Khomalli Youssef , Yaagoubi Soukaina El , Maanan Mohamed , Rhinane Hassan , Maanan Mehdi 
Published: October 2021

Abstract
Land degradation is a problem that increasingly affects large areas of territories and affects various ecosystem services provided by coastal wetlands. These marine ecosystems provide valuable benefits to the environment and to humans, including services such as coastal blue carbon sequestration (CBCS) the economic value of which is still poorly understood. This paper investigated land use/cover (LULC) changes in Moulay Bousselham lagoon (MBL) from 1971 to 2020 and their effects on CBCS variation. The transformation of LULC and their cumulative conversions in coastal wetlands were studied during the 1971-2010 and 2010-2020 periods based on LULC data. Then the InVEST model was used to quantify the carbon storage provided by coastal ecosystems in response to LULC changes. The results show that the overall area of strictly wetland habitats in the MBL has decreased by 8.83% since 1971. There were 94 types of LULC transformation over 1971-2020, with significant wetland losses marked by the conversion of wet lawn and juncus meadow to cropland. Using recent estimates of social cost of carbon (SCC) and CO2 European Emission Allowances (EUA), the monetary value of CBCS service was calculated over the entire lagoon during the study period to reach gains between 371,053 and 3,803,295US$/y and losses between -10,127 and -103,806US$/y. If current trends of habitat loss continue, the capacity of coastal habitats to sequester and store CO2 will be significantly reduced. The study shows that revenues from CBCS service can accelerate the implementation of wetland rehabilitation strategies that have a positive impact on climate regulation.
Medication overuse headache associated with decreased dopamine transporter availability in the left orbitofrontal cortex: A 11CFT PET/MR study
Authors: Liu Huanxian , Liu Jiajin , Sun Shuping , Dai Wei , Nie Binbin , Xu Baixuan , Dong Zhao , Yu Shengyuan 
Published: October 2021

Abstract
BackgroundsThe dysfunction of dopamine in the mesocorticolimbic dopamine system in MOH is unknown. Dopamine transporter (DAT) regulates dopamine clearance and neurotransmission and is sensitive to dopamine levels. A decrease in DAT availability can reflect a decrease in dopamine. To determine DAT availability abnormalities in the mesocorticolimbic dopamine system and explore functional network changes in medication overuse headache (MOH) patients.MethodsWe examined 17 MOH patients and 16 healthy controls (HCs) using integrated positron emission tomography (PET)/magnetic resonance (MR) brain scans with 11CFT, a radioligand that binds to DAT. Standardized uptake value ratio (SUVr) images were compared voxelwise between MOH patients and HCs. Then, the significantly changed cluster (p < 0.01, GRF correction) with abnormal DAT availability was selected as a specific seed region to further evaluate altered functional connectivity (FC) in MOH. SUVr and mean FC values from significantly changed regions were extracted, and partial correlation analyses with clinical measures were conducted.ResultsMOH patients had lower SUVr levels in the left rather than right orbitofrontal cortex (OFC) than HCs. There was altered FC between the left OFC and the left superior temporal pole and bilateral calcarine gyri. SUVr levels in the left OFC and the connectivity strength linking the positive brain regions with the left OFC were not correlated with clinical measures in the MOH patients.ConclusionsMOH is characterized by decreased DAT availability in the left OFC, which might reflect compensatory downregulation due to low dopamine signalling within the mesocorticolimbic dopamine system. In addition, the OFC on both sides may have different functions in the pathogenesis of MOH. Altered intrinsic FC in the left OFC was identified in MOH patients, which may provide a new perspective to understand the pathogenesis of MOH.
The Combined Association of Dietary Inflammatory Index and Resting Metabolic Rate on Cardiorespiratory Fitness in Iranian Adults
Authors: Shahinfar Hossein , Payandeh Nastaran , Shahavandi Mahshid , Mohammadpour Saba , Babaei Nadia , Ebaditabar Mojdeh , Djafarian Kurosh , Shab-Bidar Sakineh 
Published: October 2021

Abstract
Background: It has been shown that inflammation may be related to obesity and cardiovascular diseases. No study has examined the combined association of dietary inflammatory index (DII) of the diet and resting metabolic rate (RMR) on cardiorespiratory fitness (CRF). Therefore, we investigated the combined association between DII and RMR on CRF.Methods: This cross-sectional study was conducted on 270 adult subjects.The DII was calculated using a validated semi-quantified food frequency questionnaire. RMR was measured using an indirect calorimetric method. Socio-economic status, anthropometric measures, body composition and blood pressure were documented by a trained interviewer. CRF was assessed by using a graded exercise treadmill test. Results: Those who were classified into low DII/high RMR compared with high DII/low RMR had significant higher VO2Max (mL/kg/min) (p=0.005). Subjects in the low DII/low RMR category had significant lower VO2Max (mL/kg/min) in comparison with low DII/high RMR (p=0.001) and high DII/high RMR (p<0.001) respectively. Participants with a high DII score and low RMR had lower VO2Max (mL/kg/min) compared with those with a high DII score and high RMR (p=0.002). Moreover, we revealed that participants in the high DII/ high RMR group had lower odds of VO2max (L.min) compared with the low DII/ low RMR group which was significant. (OR: 0.93, 95% CI: 0.30, 0.38, p=0.009).Conclusions: Overall, consumption of a pro-inﬂammatory diet, is associated with 7% lower odds of VO2max among Iranian healthy adults. This study suggests that researchers should focus on combined relationships rather than single pair-wise associations for having a better judgment.
Complexes of Li, Na and Mg with 2D Allotropies of Second and Third Period. A Theoretical Study
Authors: Narváez Wilmer Esteban Vallejo , Garza Cesar Gabriel Vera de la , Rodríguez Luis Daniel Solís , Fomine Serguei 
Published: October 2021

Abstract
Complexes of Li, Na and Mg with graphene, silicene, phosphorene nanoflakes (NFs) and their 2D allotropies have been studied at dispersion corrected TPSS/def-TZVP level of theory. The energy partition analysis of the complexes revealed that for most of the complexes exchange and correlation energies represent dominant contributions to the binding with strong charge transfer from metal atom to a NF. The exceptions are Mg complexes of graphene and phosphorene NFs where binding is due to dispersion and correlation terms. This difference is also reflected in large Mg-NF distances suggesting weak intermolecular interactions in these complexes. The calculated activation energies for metal hopping are easily achievable at room temperatures for carbon and silicon allotropies. However, they are significantly higher for phosphorus allotropies reaching almost 18 kcal/mol. There is a reasonably good correlation between the activation energies for hopping and binding energies for graphene, silicene and phosphorene NFs. Such correlation is not observed however for graphene, silicene and phosphorene 2D allotropies
Rural Versus Urban Variations on the Factors Associated with Early Initiation of Breastfeeding in Ethiopia.
Authors: Girma Desalegn , Abita Zinie 
Published: October 2021

Abstract

Background: Early initiation of breastfeeding (EIBF) is defined as starting breastfeeding within the first hour of birth. It has clinical importance to reduce neonatal morbidity and mortality. Previously studies have been conducted in Ethiopia to identify factors associated with EIBF. However, those studies hadn’t investigated the variation of factors within rural versus urban populations. Therefore, this study is aimed to investigate the differences in factors associated with the early initiation of breastfeeding in rural-urban populations.Methods: This study was used Ethiopian Demographic and Health Survey data, 2016. A total of 3662 children aged less than 24 months were included in the study. Thus,2897 children were disaggregated into rural and the rest 765 of them were into urban. A multivariable logistic regression model was fitted to identify the determinant of EIBF. Finally, a statistically significant association was declared at a p-value of ≤0.05.Results: In rural populations, the study found that the age of mothers 15-24 years (AOR=1.50, 95%CI: 1.13,2.00), mothers not working (AOR=1.38,95%CI: 1.12,1.69), large birth size (AOR=1.44,95%CI:1.12,1.85), and participation of mothers in making health care decisions (AOR=1.43, 95%CI: 1.17,1.75) were positively associated with EIBF. Rural mothers having ≤2 children(AOR=0.55,95%CI: 0.45,0.67), living in larger to center regions (AOR=0.13,95%CI: 0.06, 0.27), and small peripheral regions (AOR=0.12,95%CI:0.06, 0.24) were negatively associated with EIBF. Irrespective of residence, the odds of EIBF were higher in vaginal delivery (RuralAOR= 4.38,95%CI:1.81,10.59; urban AOR= 3.19,95%CI:1.86, 5.48 ).In the urban population, having frequent ANC follow-ups was associated with a higher odds of EIBF.Conclusions: The study concludes that the age of mothers, working status of mothers, birth sizes, mothers participation in making health care decisions, numbers of children in the households, living in large to center regions and small peripheral regions were determinants of early initiation of breastfeeding, only rural residence. Mode of delivery was associated with EIBF, Irrespective of the residence. In the urban population, having frequent ANC follow-ups was associated with a higher odds of EIBF. Special emphases to mothers living in rural large to center and small peripheral regions should be given. Regardless of the residence, appropriate guidance and supports should be given for babies delivered through cesarean section.