bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Pulmonary Leiomyomatous Hamartomas Associated With a Bronchogenic Cyst in a Man
Authors: Nistal Manuel , Hardisson David , Riestra María Luisa 
Published: January 2021

Abstract
Multiple pulmonary leiomyomatous hamartomas (MPLHs) are extremely rare lesions. We present a case of MPLHs associated with a bronchogenic cyst in a symptomless, 46-year-old man. Previously, MLPHs have been reported to occur in men; therefore, not all cases of MPLHs represent metastases from a uterine smooth muscle tumor. Because these lesions represent a tumorlike overgrowth of normal tissue, we think that leiomyomatous hamartoma is an appropriate term to designate this entity. The possible influence of inflammatory cell mediators in the pathogenesis of MPLHs remains speculative.
Coexisting Epithelioid Trophoblastic Tumor and Choriocarcinoma of the Uterus Following a Chemoresistant Hydatidiform Mole
Authors: Shen Dan-Hua , Khoo Ui Soon , Ngan Hextan Y. S. , Ng Tung-Yau , Chau Ming-Tak , Xue Wei-Cheng , Cheung Annie N. Y. 
Published: January 2021

Abstract
The epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Herein, we describe a patient with coexisting epithelioid trophoblastic tumor and choriocarcinoma in the uterus. The patient had a history of hydatidiform mole with recurrent elevation of human chorionic gonadotrophin level that is resistant to chemotherapy. Histopathologic and immunohistochemical examination showed distinctive differences between the 2 trophoblastic tumors. The development of epithelioid trophoblastic tumor may be related to the persistence of locally invasive disease, which was unresponsive to chemotherapy. The patient responded well to surgery. The presence of an epithelioid trophoblastic tumor should be considered in chemoresistant gestational trophoblast tumor.
Renal Cell Carcinoma, Chromophobe Type, With Collecting Duct Carcinoma and Sarcomatoid Components
Authors: Gong Yun , Sun Xiaoping , Haines G. Kenneth , Pins Michael R. 
Published: January 2021

Abstract
We report a case of a 72-year-old man with a chromophobe renal cell carcinoma that had both sarcomatoid and collecting duct carcinoma components. The 7-cm tumor occupied the entire lower pole of the kidney and infiltrated the renal parenchyma and the pelvic-calyceal system. Histologically, it had an area of classic chromophobe renal cell carcinoma that merged into a sarcomatoid component. Closely intermixed with the sarcomatoid component was a collecting duct carcinoma component characterized by highly pleomorphic, epithelioid cells arranged in cords, nests, and tubulomicrocystic structures. The cords, nests, and tubules were associated with a florid desmoplastic stromal response and numerous inflammatory cells. In addition, dysplastic changes were noted in adjacent nonneoplastic collecting duct epithelium. Immunohistochemical studies confirmed the presence of 3 distinct components in this patient's tumor. To the best of our knowledge, this is the first reported case of a chromophobe renal cell carcinoma with sarcomatoid and collecting duct carcinoma components.
Malignant Perivascular Epithelioid Cell Tumor Involving the Prostate
Authors: Pan Chin-Chen , Yang An-Hang , Chiang Hung 
Published: January 2021

Abstract
Perivascular epithelioid cell tumor (PEComa) is a neoplasm chiefly composed of HMB-45–positive epithelioid cells with clear-to-granular cytoplasm and a perivascular distribution. We describe such a tumor involving the prostate and seminal vesicle in a 46-year-old man. The tumor had characteristic histologic features of PEComa. Immunohistochemically, the tumor cells were positive for HMB-45 but negative for epithelial markers, Melan-A, and S100 protein. The tumor behaved in a malignant fashion, and the patient died of the disease 4 years after diagnosis.
<i>La Celestina</i> como modelo de Rafael Chirbes en <i>Crematorio</i>
Authors: Llamas Martínez Jacobo 
Published: January 2021

Chirbes manifestó su inclinación por La Celestina principalmente en el artículo «Sin piedad ni speranza. (Revolución literaria en La Celestina)», pero también en entrevistas promocionales de En la orilla, en entradas de A ratos perdidos, sus diarios inéditos, y en las marcas de lectura de las dos ediciones de la obra conservadas en la Fundació Rafael Chirbes (la de Peter E. Russell del año 1991 y la de Francisco J. Lobera et alii del año 2000). En este artículo se comparan los juicios de Chirbes sobre el texto de Rojas con la estructura y la forma monologada de Crematorio; con los tipos, las relaciones y el registro de sus personajes; y con su tono y ambiente ruin.
Siguiendo el guion, pero guardando el decoro: cuchilladas y libreas en la <i>Tercera Celestina</i>
Authors: Navarro Durán Rosa 
Published: January 2021

La Tercera parte de la tragicomedia de Celestina se presenta como continuación de la Segunda comedia de Celestina de Feliciano de Silva; Gaspar Gómez tiene, por tanto, poca libertad al aceptar el guion de la comedia que va a terminar; pero encontrará un camino distinto devolviendo el decoro a los personajes. Lo hará haciendo que los rufianes den golpes y cuchilladas a Celestina y que ella sea castigada como alcahueta públicamente, aunque se irá a la tumba por su propio pie. Y además el escritor dará pompa, comedimiento y gran generosidad al rico y noble caballero Felides, que se desposará en ceremonia religiosa con su amada Polandria, de igual condición. El objetivo del escritor es restaurar el orden social que su modelo dejó trastocado: el mundo de los rufianes, prostitutas y alcahueta se separa por completo del de los señores, con su exhibición pública de honra, riqueza y poder.
STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF TENASCIN‐R (RESTRICTIN), AN EXTRACELLULAR MATRIX GLYCOPROTEIN OF GLIAL CELLS AND NEURONS
Authors: Nörenberg Ursel , Hubert Michael , Rathjen Fritz G. 
Published: July 2002

AbstractTenascin‐R (TN‐R) is an extracellular matrix protein associated with the surface of neurons and glial cells. Immunohistological studies reveal that TN‐R shows a restricted expression pattern in the developing nervous system. TN‐R is the smallest member of the tenascin family and is composed of four structural motifs: a cysteine‐rich segment at the N‐terminus is followed by 4.5 EGF‐like repeats. This region is followed by 9 consecutive fibronectin type III (FNIII)‐like domains and at the C‐terminus TN‐R is related to the β‐ and γ‐ chains of fibrinogen. TN‐R forms oligomeric structures as revealed by rotary shadowing electron microscopy of immunoaffinity‐purified TN‐R. TN‐R interacts with the axon‐associated F11 protein which results in an enhancement of F11 mediated neurite extension in in vitro assays. In short‐term adhesion assays it was found that neural but not fibroblastic cells attach effectively on immobilized TN‐R. The cell attachment site within TN‐R was allocated to FNIII domain 8 while the site interacting with the F11 protein could be mapped to FNIII domain 2–3.
Ionic currents in regenerating Avian vestibular hair cells
Authors: Masetto Sergio , Correia Manning J. 
Published: July 2002

AbstractBy applying the conventional whole‐cell patch‐clamp technique in combination with the slice procedure, we have investigated the properties of avian semicircular canal hair cells in situ. Passive and active electrical properties of hair cells from control animals have been compared with those of regenerating hair cells following streptomycin treatment (that killed almost all hair cells). Regenerating type II hair cells showed patterns of responses qualitatively similar to those of normal hair cells. However, parameters reflecting the total number of ionic channels and the surface area of type II hair cells changed during recovery—suggesting that new hair cells came from smaller precursors which (with time) reacquired the same electrophysiological properties as normal hair cells. Finally, we have investigated the ionic properties of a small sample of type I hair cells. Ionic currents of regenerating type I hair cells did not show, at least in the temporal window considered (up to 10 weeks from the end of the streptomycin treatment), the typical ionic currents of normal type I hair cells, but expressed instead ionic currents resembling those of type II hair cells. The possibility that regenerating type I hair cells can transdifferentiate from type II hair cells is therefore suggested.
Comparative postnatal development of dopamine D1, D2 and D4 receptors in rat forebrain
Authors: Tarazi Frank I. , Baldessarini Ross J. 
Published: July 2002

AbstractPostnatal development of dopamine D1, D2 and D4 receptors in the caudate–putamen, nucleus accumbens, frontal cortex and hippocampus was assessed in rat brain between postnatal days 7 and 60. In the caudate–putamen and nucleus accumbens, density of all three receptor subtypes increased to a peak at postnatal day 28, then declined significantly in both regions (postnatal days 35–60) to adult levels. In the frontal cortex and hippocampus, these receptors rose steadily and continuously to stable, maximal adult levels by postnatal day 60. Evidently, D1, D2 and D4 receptors follow a similar course of development in several cortical, limbic and extrapyramidal regions of rat forebrain, with selective elimination of excess dopamine receptors at the time of puberty in the caudate–putamen and accumbens but not other brain regions.
Nosological validity of dysthymia. Part I: historical, epidemiological and clinical data
Authors: Waintraub L , Guelfi JD 
Published: July 2002

SummaryDysthymia is the last diagnostic label introduced after a series of precursors to describe a disorder whose nosological status has long been dubious. The results of published epidemiological, as well as clinical studies about its presentation, course and outcome partly support the validity of this construct — although their interpretation is limited by methodological difficulties: same prevalence in many locations in the world, always lower than that of major depression, somewhat specific clinical pattern, course and outcome.
In‐hospital heart failure, first‐year ventricular dilatation and 10‐year survival after acute myocardial infarction
Authors: Gadsbøll Niels , Torp‐Pedersen Christian , Høilund‐Carlsen Poul Flemming 
Published: July 2002

AbstractBackground:Little is known about the factors that determine long‐term prognosis in patients who have survived the first year after acute myocardial infarction (AMI).Aims:To study the influence of left and right ventricular (LV and RV) dilatation during the first year after AMI on subsequent 10‐year survival in comparison with in‐hospital heart failure and other established prognostic indices.Methods:Radionuclide ventriculography was performed before the era of thrombolysis and post‐infarction ACE‐inhibition in 57 patients with AMI at hospital discharge and again 1 year later, and compared with survival the ensuing 10 years.Results:After 1 year significant LV‐dilatation (> 20%) had occurred in 32 (56%) patients. One year after the re‐investigation the mortality in these was 19% vs. 0% in patients without dilatation (P = 0.02); after 5 years the difference was 38 vs. 12% (P = 0.02), whereafter it declined and became insignificant at 10 years. Neither RV‐dilatation, nor LVEF determined at discharge or at the 1‐year reinvestigation influenced long‐term survival. In contrast, clinical heart failure recorded during the hospital stay had a sustained negative influence on long‐term survival.Conclusion:Progressive LV dilatation after discharge and clinical heart failure during the hospital stay are both determinants of late survival after AMI, whereas LV ejection fraction at hospital discharge or 1 year later has little, if any, effect on survival beyond 1‐year post‐AMI.
Discovering altered genomic expression patterns in heart: transcriptome determination by serial analysis of gene expression
Authors: Anisimov Sergey V. , Lakatta Edward G. , Boheler Kenneth R. 
Published: July 2002

AbstractThe development of cardiovascular diseases such as heart failure involve functional changes that are beneficial short‐term, but may be fatal long‐term. Current therapeutic approaches are tailored to limit progression of a disease and to maintain quality of life. At a molecular level, these disease processes involve quantitative and qualitative changes in gene expression. Although some changes in mRNA abundance may not have direct protein correlates, analysis of all the mRNAs present in a cell population (the cells transcriptome) has become a focal point of genomic research. The aim is to provide information about the dynamics of total genome expression in response to environmental changes and point to candidate genes responsible for the cascade of events that result in a disease state. One way of performing these analyses utilizes the technique of Serial Analysis of Gene Expression (SAGE). This method evaluates thousands of expressed transcripts both quantitatively and qualitatively in a single assay. In the first of two reviews on transcriptome analysis, we describe the current state of genomic research for determination of the transcriptome by Serial Analysis of Gene Expression, present the first limited SAGE analysis of rodent heart gene expression, and discuss how results generated with this approach can be applied to the study and treatment of cardiovascular diseases.
The Carvedilol Hibernation Reversible Ischaemia Trial; Marker of Success (CHRISTMAS)
Authors:   The CHRISTMAS Study Steering Committee and Investigators, Cleland John G.F. , Pennel Dudley , Ray Simon , Murray Gordon , MacFarlane Peter , Cowley Allan , Coats Andrew , Lahiri Avijit 
Published: July 2002

AbstractBackground:Carvedilol improves left ventricular (LV) function when heart failure is due to LV systolic dysfunction, but the magnitude of the response is heterogeneous among patients with coronary disease, possibly reflecting the presence or volume of hibernating myocardium. Aims: The primary objective of the study is to determine whether the presence of hibernating myocardium predicts the magnitude of improvement in LV ejection fraction in response to carvedilol among patients with heart failure and LV systolic dysfunction due to coronary disease.Methods:The study is a prospective, randomised, parallel‐group, double‐blind, multi‐centre study comparing carvedilol and placebo over a period of approximately 6 months in the above patient population. The primary end‐point is the comparison of the mean change, from baseline to the final visit, in radionuclide‐determined LV ejection fraction among patients on placebo with those on carvedilol stratified according to the presence of hibernating myocardium. Hibernating status will be determined by a combination of echocardiographic and myocardial perfusion (technetium‐99m sestamibi) imaging.Results:255 patients have undergone screening tests of which 207 have been randomised so far. The study intends to randomise 400 patients and the first report of results is expected in 2000.Conclusions:As far as we are aware this is the first randomised controlled trial to investigate the effects of treatment in patients stratified according to the presence of hibernating myocardium. The study will provide insights into the prevalence of myocardial hibernation, its natural history, and its influence on prognosis as well as the interaction between the presence of hibernating myocardium and the effects of treatment with carvedilol.
Genetic aspects of heart failure
Authors: Komajda Michel , Charron Philippe , Tesson Frédérique 
Published: July 2002

AbstractHeart failure is a major health problem and is associated with a high mortality and morbidity. Recently, the role of the genetic background in the onset and the development of the disease has been evidenced in both heart failure with and without systolic dysfunction and in familial and non‐familial forms of this condition. Preliminary studies suggest that the I/D polymorphism of the Angiotensin Converting Enzyme gene influence the development of left ventricular hypertrophy, a major determinant of heart failure. Familial hypertrophic cardiomyopathy (FHC) is a highly heterogenous autosomal dominant disease. Seven genes have been identified which all encode proteins of the sarcomere or proteins involved in the regulation of contraction. More than one hundred mutations have been evidenced. Modifier genes such as the I/D polymorphism seem to play a role in the expression of the disease. Susceptibility genes have been searched for in sporadic forms of dilated cardiomyopathy and conflicting results have been published with regard to the I/D polymorphism. Finally, familial forms of dilated cardiomyopathy (FDC) are frequent. Various modes of inheritance and phenotypes have been reported and this condition appears genetically highly heterogenous. It has been postulated that the molecular defect involved in FDC is an abnormality in the transmission of contractile force. The analysis of genetic factors that predispose to heart failure looks promising: it should allow better understanding of the underlying mechanisms that promote the progression of the disease, to identify subjects at risk of the disease who would benefit from early medical management and promote the development of pharmacogenetics.
Drug interactions as a cause of overanticoagulation on phenprocoumon or acenocoumarol predominantly concern antibacterial drugs
Authors: Penning‐van Beest Fernie J. A. , van Meegen Erik , Rosendaal Frits R. , Stricker Bruno H. 
Published: July 2002

BackgroundThe risk of hemorrhage when coumarin anticoagulants are used sharply increases when the international normalized ratio (INR) is ≥6.0. Such overanticoagulation may be caused by drug interactions. We performed a case‐control study among previously stable outpatients of an anticoagulation clinic using phenprocoumon or acenocoumarol to identify changes in the use of potentially interacting drugs related to overanticoagulation.MethodsThree hundred case patients with INR values ≥6.0 were compared with 302 randomly selected matched control subjects with INR values within the target zone. Information on changes in the use of 87 potentially interacting drugs in the 4 weeks before the index day was collected by interviewing patients and by reviewing the anticoagulant medical record.ResultsForty‐five potentially interacting drugs were not used in the 4‐week study period, and only 15 drugs were used by at least 10 patients. For a number of drugs, too few patients had a relevant change in use to judge their association with overanticoagulation. A course of a combination product of sulfamethoxazole and trimethoprim strongly increased the risk of overanticoagulation (adjusted odds ratio, 24.2; 95% confidence interval [CI], 2.8 to 209.1; population attributable risk percentage [PAR%], 5.7%), especially in patients receiving acenocoumarol. Penicillins were associated with a risk of overanticoagulation of 2.4 (95% CI, 1.00 to 5.5); the corresponding PAR% was 3.4%. The effect was confined to amoxicillin (INN, amoxicilline) plus clavulanic acid.ConclusionDrug interactions as a cause of overanticoagulation predominantly concerned antibacterial drugs. If possible, the use of sulfamethoxazole‐trimethoprim and amoxicillin plus clavulanic acid should be avoided in patients receiving coumarins. If there is no therapeutic alternative available, increased monitoring of INR values is warranted to prevent overanticoagulation and potential bleeding complications.Clinical Pharmacology & Therapeutics (2001) 69, 451–457; doi: 10.1067/mcp.2001.115723
Evaluation and modulation of DNA lesion bypass in an SV40 large T antigen‐based in vitro replication system
Authors: Szeltner Zoltán , Póti Ádám , Harami Gábor M. , Kovács Mihály , Szüts Dávid 
Published: January 2021

DNA damage removal by nucleotide excision repair (NER) and replicative bypass via translesion synthesis (TLS) and template switch (TSw) are important in ensuring genome stability. In this study, we tested the applicability of an SV40 large T antigen‐based replication system for the simultaneous examination of these damage tolerance processes. Using both Sanger and next‐generation sequencing combined with lesion‐specific qPCR and replication efficiency studies, we demonstrate that this system works well for studying NER and TLS, especially its one‐polymerase branch, while it is less suited to investigations of homology‐related repair processes, such as TSw. Cis‐syn cyclobutane pyrimidine dimer photoproducts were replicated with equal efficiency to lesion‐free plasmids in vitro, and the majority of TLS on this lesion could be inhibited by a peptide (PIR) specific for the polη‐PCNA interaction interface. TLS on 6–4 pyrimidine–pyrimidone photoproduct proved to be inefficient and was slightly facilitated by PIR as well as by a recombinant ubiquitin‐binding zinc finger domain of polη in HeLa extract, possibly by promoting polymerase exchange. Supplementation of the extract with recombinant PCNA variants indicated the dependence of TLS on PCNA ubiquitylation. In contrast to active TLS and NER, we found no evidence of successful TSw in cellular extracts. The established methods can promote in vitro investigations of replicative DNA damage bypass.
Unconventional Image‐Sensing and Light‐Emitting Devices for Extended Reality
Authors: Park Jinhong , Seung Hyojin , Kim Dong Chan , Kim Min Sung , Kim Dae‐Hyeong 
Published: January 2021

AbstractExtended reality (XR) refers to a space where physical and digital elements coexist and comprises three elements, namely, environment, human, and computer, which interact with each other. Image sensors and displays are the core elements of XR systems because visual information is important for recognizing and judging objects. Recently, new features of image sensors and displays that are useful for developing next‐generation XR systems have been reported. For example, a miniaturized version of image sensors with the superb object detection and recognition capability offers new opportunities for machine vision technology. Furthermore, transparent and deformable displays are the key components of XR systems because they not only provide highly realistic virtual image information but also serve as efficient user interfaces. Herein, the recent progresses in such unconventional image sensors and display technologies are reviewed. First, image sensors with features of wavelength‐selective photodetection for color discrimination, neuromorphic image acquisition for facile pattern recognition, and curved image sensor designs inspired by biological eyes for miniaturization and unconventional imaging performances are discussed. Then, light‐emitting device technologies focusing on devices with transparency and deformable form factors are described. Finally, the review is concluded with a brief summary and a future outlook.