bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Heart Rate Variability During Sleep Predicts Vagus Nerve Stimulation Outcome Better in Patients With Drug-Resistant Epilepsy
Authors: Fang Xi , Liu Hong-Yun , Wang Zhi-Yan , Yang Zhao , Cheng Tung-Yang , Hu Chun-Hua , Hao Hong-Wei , Meng Fan-Gang , Guan Yu-Guang , Ma Yan-Shan , Liang Shu-Li , Lin Jiu-Luan , Zhao Ming-Ming , Li Lu-Ming 
Published: July 2021

Objective: Vagus nerve stimulation (VNS) is an adjunctive and well-established treatment for patients with drug-resistant epilepsy (DRE). However, it is still difficult to identify patients who may benefit from VNS surgery. Our study aims to propose a VNS outcome prediction model based on machine learning with multidimensional preoperative heart rate variability (HRV) indices.Methods: The preoperative electrocardiography (ECG) of 59 patients with DRE and of 50 healthy controls were analyzed. Responders were defined as having at least 50% average monthly seizure frequency reduction at 1-year follow-up. Time domain, frequency domain, and non-linear indices of HRV were compared between 30 responders and 29 non-responders in awake and sleep states, respectively. For feature selection, univariate filter and recursive feature elimination (RFE) algorithms were performed to assess the importance of different HRV indices to VNS outcome prediction and improve the classification performance. Random forest (RF) was used to train the classifier, and leave-one-out (LOO) cross-validation was performed to evaluate the prediction model.Results: Among 52 HRV indices, 49 showed significant differences between DRE patients and healthy controls. In sleep state, 35 HRV indices of responders were significantly higher than those of non-responders, while 16 of them showed the same differences in awake state. Low-frequency power (LF) ranked first in the importance ranking results by univariate filter and RFE methods, respectively. With HRV indices in sleep state, our model achieved 74.6% accuracy, 80% precision, 70.6% recall, and 75% F1 for VNS outcome prediction, which was better than the optimal performance in awake state (65.3% accuracy, 66.4% precision, 70.5% recall, and 68.4% F1).Significance: With the ECG during sleep state and machine learning techniques, the statistical model based on preoperative HRV could achieve a better performance of VNS outcome prediction and, therefore, help patients who are not suitable for VNS to avoid the high cost of surgery and possible risks of long-term stimulation.
Usefulness of the Texture Signatures Based on Multiparametric MRI in Predicting Growth Hormone Pituitary Adenoma Subtypes
Authors: Liu Chen-Xi , Heng Li-Jun , Han Yu , Wang Sheng-Zhong , Yan Lin-Feng , Yu Ying , Ren Jia-Liang , Wang Wen , Hu Yu-Chuan , Cui Guang-Bin 
Published: July 2021

ObjectiveTo explore the usefulness of texture signatures based on multiparametric magnetic resonance imaging (MRI) in predicting the subtypes of growth hormone (GH) pituitary adenoma (PA).MethodsForty-nine patients with GH-secreting PA confirmed by the pathological analysis were included in this retrospective study. Texture parameters based on T1-, T2-, and contrast-enhanced T1-weighted images (T1C) were extracted and compared for differences between densely granulated (DG) and sparsely granulated (SG) somatotroph adenoma by using two segmentation methods [region of interest 1 (ROI1), excluding the cystic/necrotic portion, and ROI2, containing the whole tumor]. Receiver operating characteristic (ROC) curve analysis was performed to determine the differentiating efficacy.ResultsAmong 49 included patients, 24 were DG and 25 were SG adenomas. Nine optimal texture features with significant differences between two groups were obtained from ROI1. Based on the ROC analyses, T1WI signatures from ROI1 achieved the highest diagnostic efficacy with an AUC of 0.918, the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 85.7, 72.0, 100.0, 100.0, and 77.4%, respectively, for differentiating DG from SG. Comparing with the T1WI signature, the T1C signature obtained relatively high efficacy with an AUC of 0.893. When combining the texture features of T1WI and T1C, the radiomics signature also had a good performance in differentiating the two groups with an AUC of 0.908. In addition, the performance got in all the signatures from ROI2 was lower than those in the corresponding signature from ROI1.ConclusionTexture signatures based on MR images may be useful biomarkers to differentiate subtypes of GH-secreting PA patients.
FOXP3 Inhibits the Metastasis of Breast Cancer by Downregulating the Expression of MTA1
Authors: Liu Chenlin , Han Jun , Li Xiaoju , Huang Tonglie , Gao Yuan , Wang Baolong , Zhang Kuo , Wang Shuning , Zhang Wangqian , Li Weina , Hao Qiang , Li Meng , Zhang Yingqi , Zhang Cun 
Published: July 2021

BackgroundFOXP3, as a tumour suppressor gene, has a vital function in inhibiting the metastasis of breast cancer cells, but the mechanisms by which it inhibits metastasis have not been fully elucidated. This study intended to explore a new mechanism by which FOXP3 inhibits breast cancer metastasis.MethodsBioinformatic analysis was performed to identify potential downstream molecules of FOXP3. The function of FOXP3 in inhibiting MTA1 expression at the mRNA and protein levels was verified by real-time PCR and Western blot analysis. The interaction between FOXP3 and the MTA1 promoter was verified by transcriptomic experiments. In vitro and in vivo experiments were used to determine whether the regulation of MTA1 by FOXP3 affected the invasion and migration of breast cancer cells. Immunohistochemistry was adopted to explore the correlation between the expression levels of FOXP3 and MTA1 in breast cancer samples.ResultsBioinformatics-based sequencing suggested that MTA1 is a potential downstream molecule of FOXP3. FOXP3 downregulated the expression of MTA1 in breast cancer cells by directly inhibiting MTA1 promoter activity. Importantly, FOXP3’s regulation of MTA1 affected the ability of breast cancer cells to invade and metastasize in vitro and in vivo. Moreover, analysis of clinical specimens showed a significant negative correlation between the expression levels of FOXP3 and MTA1 in breast cancer.ConclusionWe systematically explored a new mechanism by which FOXP3 inhibits breast cancer metastasis via the FOXP3-MTA1 pathway.
Metabolomic Profile and Cytotoxic Activity of Cissus incisa Leaves Extracts
Authors: Nocedo-Mena Deyani , Ríos María Yolanda , Ramírez-Cisneros M. Ángeles , González-Maya Leticia , Sánchez-Carranza Jessica N. , Camacho-Corona María del Rayo 
Published: July 2021

Cissus incisa leaves have been traditionally used in Mexican traditional medicine to treat certain cancerous illness. This study explored the metabolomic profile of this species using untargeted technique. Likewise, it determined the cytotoxic activity and interpreted all data by computational tools. The metabolomic profile was developed through UHPLC-QTOF-MS/MS for dereplication purposes. MetaboAnalyst database was used in metabolic pathway analysis and the network topological analysis. Hexane, chloroform/methanol, and aqueous extracts were evaluated on HepG2, Hep3B, HeLa, PC3, A549, and MCF7 cancer cell lines and IHH immortalized hepatic cells, using Cell Titer proliferation assay kit. Hexane extract was the most active against Hep3B (IC50 = 27 ± 3 μg/mL), while CHCl3/MeOH extract was the most selective (SI = 2.77) on the same cell line. A Principal Component Analysis (PCA) showed similar profiles between the extracts, while a Venn diagram revealed 80 coincident metabolites between the bioactive extracts. The sesquiterpenoid and triterpenoid biosynthesis pathway was the most significant identified. The Network Pharmacology (NP) approach revealed several targets for presqualene diphosphate, phytol, stearic acid, δ-tocopherol, ursolic acid and γ-linolenic acid, involved in cellular processes such as apoptosis. This work highlights the integration of untargeted metabolomic profile and cytotoxic activity to explore plant extracts, and the NP approach to interpreting the experimental results.
Sur l'origine de la dénomination « Siam »
Authors: Ferlus Michel 
Published: July 2021

Les recherches sur l'origine et les usages des ethnonymes sont une activité de nature pluridisciplinaire où la linguistique historique tient le rôle principal.
On démontre que la famille des termes, Siam, Chan, Ahom (et Assam), est issue par troncation de kosambi (ko)sam(bï), nom de prestige des premiers États chan, emprunté à la géographie de l'Inde (Kausâmbï, lieu de prêche du Bouddha). Dès les plus anciennes attestations épigraphiques, on constate l'usage parallèle d'un qualificatif issu du sanskrit syama « noir, brun de teint (comme marque de beauté) ». L'adaptation de cet étymon aux langues porteuses, khmer, birman ou thaï, conduit à une homographie avec l'ethnonyme issu de (ko)sam(bï). Les essais d'explication antérieurs ont négligé la connotation valorisante des termes issus de syama. Il a même été supposé que le terme « Siam » tirait son origine de la complexion foncée des autochtones ayant précédé les Thaï.
Ces interprétations hâtives montrent que les recherches sur l'origine des ethnonymes doivent être menées avec prudence.
La paroisse des affranchis. Communauté, identité et religion dans le village de Kdol, Cambodge (1898-1979)
Authors: Guérin Mathieu , Vogin Gérald 
Published: July 2021

The Freed Slaves' Parish.
Community, Identity and Religion in the Village ofKdol, Cambodia (1898-1979).
Mathieu Guérin and Gerald Vogin.

In 1897, slavery and the trafficking of the inhabitants of the Highlands were permanently abolished in the Cambodian kingdom, then under French rule. A missionary from the French Catholic Missions, Father Lazard, gathered at that time a group of freed slaves in the village of Kdol on the Mekong river. A very specific community of new converts emerged between groups of Muslim Chams, Buddhist Khmers and Christian Vietnamese. This community survived all the political regimes that Cambodia experienced during the twentieth century, including the war and the Khmer Rouge regime. By converting to Catholicism, the freed slaves ofKdol achieved a new identity and status in the Khmer kingdom.
La frontière entre Espagne Ultérieure et Citérieure au début du IIe siècle av. J.-C
Authors: Jacob Pierre 
Published: July 2021

El limite entre Hispania Ulterior y Hispania Citerior a principios del siglo II antes de Cristo
En su sección sudeste la frontera entre España Ulterior y Citerior ha cambiado por última vez en época augustea. Este estado de la frontera, así como el trazado de época republicana, generalmente fechado en 197 A. C, pueden ser reconstruidos con ayuda de las fuentes antiguas. En este artículo, trataremos de demostrar la existencia de un recorrido anterior a 197 : durante los veinte años después de la conquista romana, el limite entre provincias seguía el Júcar, identificado por J. Carcopino en 1953 como el Hiberus del tratado romano-cartaginés de 226. Esta primera etapa ha dejado huellas en las fuentes históricas y geográficas posteriores.
Integración de comunidades griegas y barbaras en Oriente y en Occidente (Estrabón III, 4, 8 y BMI 886)
Authors: Santiago Rosa A. 
Published: July 2021

Intégration de communautés grecques et barbares en Orient et en Occident (Strabon III, 4, 8 et BMI 886).

L’analyse de deux textes, l’un de Strabon, l’autre, épigraphique, révèle une situation parallèle dans l’évolution des relations entre les populations grecques et leurs voisins indigènes, dans un cas, à Emporion, dans la plus occidentale des colonies grecques, au nord-ouest de la péninsule ibérique, et, dans l’autre, à Halicarnasse, vieille colonie grecque de la côte d’Asie Mineure.
L’analyse précise de l’inscription d’Halicarnasse incite à y voir, plus qu’un témoignage de paix civile après l’affaiblissement de la tyrannie, une habile manœuvre du tyran pour renforcer ses positions.
ANALISIS LAPORAN KEUANGAN PADA PT. AKASHA WIRA INTERNATIOAL Tbk. PERIODE 2015-2019 MENGGUNAKAN METODE ANGKA INDEKS
Authors: Nurmalina Radna , Suasri Eni , Munawaroh Wiwin 
Published: July 2021

Abstrak

Analisis laporan keuangan PT. Akasha Wira International Tbk. merupakan keseluruhan laporan keuangan dengan tujuan untuk mengambil keputusan. Tujuan dari penelitian ini adalah untuk menghitung dan menganalisis laporan laba/rugi komprehensif dan laporan posisi keuangan atau neraca pada PT. Akasha Wira International Tbk menggunakan metode angka indeks tahun dasar yang digunakan adalah tahun dasar yang hanya fokus pada 1 tahun yang digunakan. Untuk perhitungan metode angka indeks menunjukan hasil yang fluktuatif. Terlihat pada hasil perhitungan laporan laba/rugi komprehensif peningkatan laba usaha tertinggi pada tahun 2016 yaitu sebesar Rp 427.828.000 atau 32,54% dan untuk laporan posisi keuangan mengalami peningkatan tertinggi pada jumlah liabilitas dan ekuitas adalah tahun 2018 sebesar Rp 881.275.000 atau 34,91% sehingga tingkat pertumbuhan pada perusahaan dapat dikatakan sehat karena dapat memaksimalkan penggunaan ekuitas selama 5 tahun.
Kata Kunci :(Analaisis, Laporan Keuangan, Metode Angka Indeks)
The Chai Point ACQT: Brewing Tradition and Technology for Success
Authors: Nair Sindhu Shantha , Smritika S P 
Published: July 2021

The unique selling proposition of Chai Point was a combination of Access, Convenience, Quality and Turnaround time (ACQT). The route map of Chai point is quite interesting; in 2009, the idea surfaces, 2010 it becomes a reality and by 2011, around 10 Chai Point Stores are opened in Bangalore, 1 million chai cups were sold and add-on products like Vada Pao and Samosa were introduced. In 2014, Chai on call, Website, mobile app were launched and went on cloud. In 2015, Fidelity invests $10mn and in 2016, PrioriTea mobile wallet, reward program and boxC were launched. By 2017 they were able to open 97 outlets across Bangalore and are venturing into other cities. The growth propositions of Chai Point were innovation and consistency.
Competitive Advantage and Risk: Impact on Indian Stock Market
Authors: Rohit Babitha , Pinto Prakash , Sushmitha R , Munshi M M 
Published: July 2021

The current study examines the performance of top 40 companies based on market capitalization for the period of 5 years (2015-2019). Competitive advantage is measured using asset turnover ratio and profit margin and risk is measured using financial leverage. Book to market ratio is used as a measure of market performance of the firms. The results indicate that profit margin has the most significant impact on the market performance in the Indian stock market.
Sree Narayana Movement and Social Transformation of Modern Kerala: A Bird’s - Eye View
Authors: Anirudhan Shaji 
Published: July 2021

Among the various factors that contributed for the transformation of Kerala into a modern democratic society the role played by Sree Narayana movement was most significant. Realising that the political power was the master key to social progress, the leaders of the movement came into tacit understanding with non Hindus, made permutations and combinations with them to maintain and strengthen their position in the society. Through their protests, incessant conflicts and assertions, they succeeded in transforming the pyramidal social structure of Kerala into pillar structure. From the position of caste victims they could elevate themselves to the makers of their own destinies. They also succeeded in politicising the social relations. The philosophies and pragmatic approaches propounded by Narayana Guru for the material and spiritual advancement of the backward caste people of Kerala was found successful that contributed for the social transformation from structural relations to human relations and from caste hierarchical structure to inter-personal relations.
The Motivation of Construction Khayaban-e- Herat (Herat Street)
Authors: Rahguzar Nazir Ahmad 
Published: July 2021

After Herat had conquered by Timor his son ascended the throne in Khorasan. Herat was enclosed to AL-Krt square shape boundaries and was developed significantly to northern. North to south length streets were theme of gardens and architectural constructions.The aim of this article is to get to know more about these streets as a link factor for constructions, streams and gardens of streets beside their role identifying and rating alongside history to get their unique-unity sense in the boundaries. The approach of this article is historical, descriptive, analytical and data collection both library and field. The historical aspect of research is derived from the historical books and its descriptive is taken from historical-descriptive books in compare with left arts in Herat streets.It should be noted that Timor princes had high interest on art and culture beside their ambitions, fun and entertaining in which caused the mentioned streets to take the multi-purposes complexes and places as where to be a place of power display. Timor’s garden establishment in Herat specially in streets were made for general and special places of poem, entertainment and promenade. The opening of streets in north and western north of Herat transferred from a commuting place to an entertainment and promenade destination with proper weather for various celebrations and ceremonies for different occasions. Undoubtedly, existence of uncountable cemeteries and graves in this area made it as a spiritual symbolism for Herat.
An An Analysis of Customer Satisfaction towards Online Shopping with Special Reference to Madurai City
Authors: Akila Mary J , Benita S 
Published: July 2021

In recent days, online marketing is a great revolution in the world. Over the last decade, most business organizations are running with modern technological change. The advanced technology getting better marketing performance. In this society, retailers are devising strategies to meet out the demand of online buyers. Online retailers are studying buyer’s behavior and perception of the consumer in the field of web shopping. Therefore, we have also chosen to analyses consumer’s attitudes towards online shopping and also studying the factors influencing consumers to buy their product on the web in this busiest fast-moving world. The population selected for the research is Madurai city, and narrowed down to buyers who are using the internet to buy online, includes students, homemakers, professionals; the sample size selected for this analysis is 50, and we have used the convenience sampling technique.
MGNREGA: Ensures Guaranteed Wage Employment in Rural Area
Authors: Shankar Kumbhar Pankaj Kamal 
Published: July 2021

The Mahatma Gandhi Nation Rural Employment Guarantee Scheme (MGNREGS) is perhaps the world largest right to work model being implemented in India. The most distinctive feature of MGNREGA from the earlier rural public works programme is that it has provided a legal entitlement to work on demand. But unfortunately MGNREGA is not meeting demand for wage employment in rural areas it may be because poor transparency and accountability and lack of capacity on the part of Panchayats. Lack of awareness among villagers about the provisions of the Act and not using proper strategy for awareness building is another factor which is responsible for lacuna due to which proper implementation of MGNREGS is remain challenge in rural areas.There are still lots of problems in the implementation of MGNREGA. Still, it has not reached the poor and needy due to lack of interest of the implementing agencies especially local self governance in rural area. MGNERGS needs more creative innovative and time bound efforts from the local governance institutions to meet the demand for wage employment in rural area. Gram Sabha and Social audit can play crucial role to implement these scheme.The present paper is based of secondary source of literature, discusses about whether MGNREGA really meeting demands of wage employment at village level and suggests mechanism for effective implementation of MGNREGA.
Hubungan Penggunaan Gigi Tiruan dengan Kualitas Hidup Lansia di Wilayah Kerja Puskesmas Batu Aji
Authors: Badri Isna Aglusi 
Published: July 2021

Masalah kesehatan gigi dan mulut yang sering terjadi pada manula adalah terjadinya peningkatan karies gigi penyakit periodontal, yang merupakan penyebab utama kehilangan gigi untuk manula di Indonesia. Penggunaan gigi tiruan akan meningkatkan kualitas hidup dan mengembalikan kondisi rasa nyeri pada otot masseter, sendi temporomandibula atau otot regio temporalis. Penelitian ini bertujuan untuk mengetahui hubungan penggunaan gigi tiruan dengan kualitas hidup pada lansia Di Wilayah Kerja Puskesmas Batu Aji Kota Batam. Penelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional, pengambilan sampel menggunakan non probability sampling secara purposive sampling, yaitu pada wilayah kerja Puskesmas Batu Aji Kota Batam, lansia berusia 60 tahun ke atas yang menggunakan dan tidak menggunakan gigi tiruan, sehingga diperoleh sampel sebanyak 67 lansia. Penentuan gigi tiruan menggunakan pemeriksaan langsung dan kualitas hidup yang yang menggunakan WHOQOL-BREF. Hasil analisis chi square menunjukkan ada hubungan antara penggunaan gigi tiruan dengan kualitas hidup pada lansia yang dilihat pada Nilai p = 0,029 < 0,05. Diharapkan lansia dapat memperoleh informasi penting tentang penggunaan gigi tiruan agar dapat terciptanya kualitas hidup pada lansia Kata kunci:lansia; penggunaan gigi tiruan; kualitas hidupTHE RELATIONSHIP OF THE USE OF DENTURES AND THE QUALITY OF LIFE OF THE ELDERLY AAT BATU AJI DISTRICT HEALTH CENTRE Abstract Dental and oral health problems that often occur in the elderly are the increase in periodontal disease dental caries, which is the main cause of tooth loss for the elderly in Indonesia. The use of dentures will improve the quality of life and restore painful conditions in the masseter muscles, temporomandibular joints or muscles of the temporalis region. This study was aimed to determine the relationship between the use of dentures and the quality of life in the elderly at Batu Aji District Health Centre, Batam City. This research was a descriptive analytic study with a cross sectional approach. Sampling used non-probability sampling by purposive sampling, The samples were elderly aged 60 years and over who use and do not use dentures, so that a sample of 67 elderly were obtained. Denture determination used direct examination and quality of life used WHOQOL-BREF. The results of the chi square analysis shows that there are a relationship between the use of dentures and the quality of life in the elderly, which was seen at p = 0.029 <0.05. It is hoped that the elderly can listen to important information about the use of dentures in order to create a quality of life in the elderly Keywords:elderly; use of dentures; quality of life