bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrinsic motivation in patients with Parkinson’s disease: a neuropsychological investigation of curiosity using dopamine transporter imaging
Authors: Shigemune Yayoi , Kawasaki Iori , Midorikawa Akira , Baba Toru , Takeda Atsushi , Abe Nobuhito 
Published: January 2021

AbstractBoth intrinsic and extrinsic motivation are believed to involve brain regions that are innervated by the dopaminergic pathway. Although dopaminergic neurons in the midbrain deteriorate in Parkinson’s disease (PD), it remains unclear whether intrinsic motivation is impaired in PD patients. To address this issue, we investigated intrinsic motivation in PD patients using a task designed to assess the “Pandora effect,” which constitutes a curiosity for resolving uncertainty, even if this curiosity is likely to result in negative consequences. Twenty-seven PD patients and 27 age-matched healthy controls (HCs) completed a curiosity task in which they were required to decide either to view or skip negative pictures (e.g., snakes, spiders) and an examination battery that included the Mini-Mental State Examination, a verbal fluency test, the Trail Making Test, 10-word recall tests, and questionnaires for behavioral inhibition/activation and depression. DaTSCAN images to assess the distribution of dopamine transporters in the striatum were acquired only from PD patients. The results revealed that PD patients, relative to the HCs, viewed the pictures less frequently under both the certain and uncertain conditions. However, both the PD patients and HCs viewed the pictures at a higher frequency under the uncertain condition than under the certain condition. In the PD patients, the proportion of pictures viewed under the certain condition was positively correlated with the distribution of dopamine transporters in the striatum. These results suggest that despite the overall decreasing level of interest in viewing negative pictures, the motivation to resolve uncertainty is relatively intact in PD patients.
Evaluating the accuracy and uncertainty of atmospheric and wave model hindcasts during severe events using model ensembles
Authors: Abdolali Ali , van der Westhuysen Andre , Ma Zaizhong , Mehra Avichal , Roland Aron , Moghimi Saeed 
Published: January 2021

AbstractVarious uncertainties exist in a hindcast due to the inabilities of numerical models to resolve all the complicated atmosphere-sea interactions, and the lack of certain ground truth observations. Here, a comprehensive analysis of an atmospheric model performance in hindcast mode (Hurricane Weather and Research Forecasting model—HWRF) and its 40 ensembles during severe events is conducted, evaluating the model accuracy and uncertainty for hurricane track parameters, and wind speed collected along satellite altimeter tracks and at stationary source point observations. Subsequently, the downstream spectral wave model WAVEWATCH III is forced by two sets of wind field data, each includes 40 members. The first ones are randomly extracted from original HWRF simulations and the second ones are based on spread of best track parameters. The atmospheric model spread and wave model error along satellite altimeters tracks and at stationary source point observations are estimated. The study on Hurricane Irma reveals that wind and wave observations during this extreme event are within ensemble spreads. While both Models have wide spreads over areas with landmass, maximum uncertainty in the atmospheric model is at hurricane eye in contrast to the wave model.
A family of solutions to the inverse problem in gravitation: building a theory around a metric
Authors: Suvorov Arthur G. 
Published: January 2021

AbstractA method is presented to construct a particular, non-minimally coupled scalar–tensor theory such that a given metric is an exact vacuum solution in that theory. In contrast to the standard approach in studies of gravitational dynamics, where one begins with an action and then solves the equations of motion, this approach allows for an explicit theory to be built around some pre-specified geometry. Starting from a parameterized black hole spacetime with generic, non-Kerr hairs, it is shown how an overarching family of theories can be designed to fit the metric exactly.
‘My Point of Departure for Analytics is Extreme Skepticism’: Implications Derived from An Investigation of University Teachers’ Learning Analytics Perspectives and Design Practices
Authors: Kaliisa Rogers , Mørch Anders I. , Kluge Anders 
Published: January 2021

AbstractThe literature until 2020 has forecasted a significant uptake of learning analytics (LA) to support learning design in higher education. However, there remain only a few investigations into teachers’ course design practices and their perspectives on LA as a tool to support their design practices. This paper presents findings from an examination of 16 university teachers’ design practices and perspectives on LA at two Norwegian universities (The University of Oslo and Oslo Metropolitan University). On one hand, findings identified situational factors, feedback sources and teachers’ intuition as key influencers of teachers’ course design decisions. On the other hand, guided by principles of the technology acceptance model, this study identified mixed reactions amongst teachers regarding the awareness, understanding and potential use of LA to support course design practices. In particular, most teachers appreciated the formative and normative value of LA to provide more objective evidence about students’ learning patterns and to shape learning trajectories, but some were skeptical about the evaluative role where LA is used to evaluate teachers’ and students’ performance based on unnuanced data (e.g. no theory guidance) with limited depth in observation. This article contributes to the understanding of factors fundamental to linking LA to teachers’ course design practices by synthesizing findings to propose a ‘bi-directional LA-course design’ conceptual framework that clarifies key elements that influence teachers’ design practices and highlighting their implications for LA integration.
The 2010 Horizontal Merger Guidelines After 10 Years
Authors: Farrell Joseph , Shapiro Carl 
Published: January 2021

AbstractThis paper introduces the Special Issue of the Review of Industrial Organization that studies the impact of the 2010 Horizontal Merger Guidelines after 10 years
On August 19, 2010, the U.S. Department of Justice (DOJ) and the Federal Trade Commission (FTC) issued newly updated Horizontal Merger Guidelines (2010 Guidelines) [See https://www.ftc.gov/sites/default/files/attachments/merger-review/100819hmg.pdf.]. The 2010 Guidelines begin by stating:
“These Guidelines outline the principal analytical techniques, practices, and the enforcement policy of the Department of Justice and the Federal Trade Commission (the “Agencies”) with respect to mergers and acquisitions involving actual or potential competitors (“horizontal mergers”) under the federal antitrust laws.”
Since the first Merger Guidelines were issued by the DOJ 1968, the merger guidelines have been an important channel by which economic research and learning affects antitrust enforcement. Each iteration of the merger guidelines has reflected the economic thinking of the day. Each iteration also has made a substantial impact on merger enforcement and the development of antitrust law. This special issue examines the impact of the 2010 Merger Guidelines after 10 years.
In situ bioremediation of Fenton’s reaction–treated oil spill site, with a soil inoculum, slow release additives, and methyl-β-cyclodextrin
Authors: Talvenmäki Harri , Saartama Niina , Haukka Anna , Lepikkö Katri , Pajunen Virpi , Punkari Milla , Yan Guoyong , Sinkkonen Aki , Piepponen Tuomas , Silvennoinen Hannu , Romantschuk Martin 
Published: January 2021

AbstractA residential lot impacted by spills from a leaking light heating oil tank was treated with a combination of chemical oxidation and bioremediation to avoid technically challenging excavation. The tank left emptied in the ground was used for slow infiltration of the remediation additives to the low permeability, clayey soil. First, hydrogen peroxide and citrate chelate was added for Fenton’s reaction–based chemical oxidation, resulting in a ca. 50% reduction from the initial 25,000 mg/kg average oil concentration in the soil below the tank. Part of this was likely achieved through mobilization of oily soil into the tank, which was beneficial in regards to the following biological treatment. By first adding live bacteria in a soil inoculum, and then oxygen and nutrients in different forms, an approximately 90% average reduction was achieved. To further enhance the effect, methyl-β-cyclodextrin surfactant (CD) was added, resulting finally in a 98% reduction from the initial average level. The applicability of the surfactant was based on laboratory-scale tests demonstrating that CD promoted oil degradation and, unlike pine soap, was not utilized by the bacteria as a carbon source, and thus inhibiting degradation of oils regardless of the positive effect on biological activity. The effect of CD on water solubility for different hydrocarbon fractions was tested to serve as the basis for risk assessment requirements for authorizing the use of the surfactant at the site.
Evaluation of deep learning-based approaches for COVID-19 classification based on chest X-ray images
Authors: KC Kamal , Yin Zhendong , Wu Mingyang , Wu Zhilu 
Published: January 2021

AbstractThe COVID-19, novel coronavirus or SARS-Cov-2, has claimed hundreds of thousands of lives and affected millions of people all around the world with the number of deaths and infections growing exponentially. Deep convolutional neural network (DCNN) has been a huge milestone for image classification task including medical images. Transfer learning of state-of-the-art models have proven to be an efficient method of overcoming deficient data problem. In this paper, a thorough evaluation of eight pre-trained models is presented. Training, validating, and testing of these models were performed on chest X-ray (CXR) images belonging to five distinct classes, containing a total of 760 images. Fine-tuned models, pre-trained in ImageNet dataset, were computationally efficient and accurate. Fine-tuned DenseNet121 achieved a test accuracy of 98.69% and macro f1-score of 0.99 for four classes classification containing healthy, bacterial pneumonia, COVID-19, and viral pneumonia, and fine-tuned models achieved higher test accuracy for three-class classification containing healthy, COVID-19, and SARS images. The experimental results show that only 62% of total parameters were retrained to achieve such accuracy.
DREAM
Authors: Gong Zhu-Qing , Gao Peng , Jiang Chao , Xing Xiu-Xia , Dong Hao-Ming , White Tonya , Castellanos F. Xavier , Li Hai-Fang , Zuo Xi-Nian 
Published: January 2021

AbstractRhythms of the brain are generated by neural oscillations across multiple frequencies. These oscillations can be decomposed into distinct frequency intervals associated with specific physiological processes. In practice, the number and ranges of decodable frequency intervals are determined by sampling parameters, often ignored by researchers. To improve the situation, we report on an open toolbox with a graphical user interface for decoding rhythms of the brain system (DREAM). We provide worked examples of DREAM to investigate frequency-specific performance of both neural (spontaneous brain activity) and neurobehavioral (in-scanner head motion) oscillations. DREAM decoded the head motion oscillations and uncovered that younger children moved their heads more than older children across all five frequency intervals whereas boys moved more than girls in the age of 7 to 9 years. It is interesting that the higher frequency bands contain more head movements, and showed stronger age-motion associations but weaker sex-motion interactions. Using data from the Human Connectome Project, DREAM mapped the amplitude of these neural oscillations into multiple frequency bands and evaluated their test-retest reliability. The resting-state brain ranks its spontaneous oscillation’s amplitudes spatially from high in ventral-temporal areas to low in ventral-occipital areas when the frequency band increased from low to high, while those in part of parietal and ventral frontal regions are reversed. The higher frequency bands exhibited more reliable amplitude measurements, implying more inter-individual variability of the amplitudes for the higher frequency bands. In summary, DREAM adds a reliable and valid tool to mapping human brain function from a multiple-frequency window into brain waves.
Adenosine Signaling and Clathrin-Mediated Endocytosis of Glutamate AMPA Receptors in Delayed Hypoxic Injury in Rat Hippocampus: Role of Casein Kinase 2
Authors: Qin Xin , Zaki Michael G. , Chen Zhicheng , Jakova Elisabet , Ming Zhi , Cayabyab Francisco S. 
Published: January 2021

AbstractChronic adenosine A1R stimulation in hypoxia leads to persistent hippocampal synaptic depression, while unopposed adenosine A2AR receptor stimulation during hypoxia/reperfusion triggers adenosine-induced post-hypoxia synaptic potentiation (APSP) and increased neuronal death. Still, the mechanisms responsible for this adenosine-mediated neuronal damage following hypoxia need to be fully elucidated. We tested the hypothesis that A1R and A2AR regulation by protein kinase casein kinase 2 (CK2) and clathrin-dependent endocytosis of AMPARs both contribute to APSPs and neuronal damage. The APSPs following a 20-min hypoxia recorded from CA1 layer of rat hippocampal slices were abolished by A1R and A2AR antagonists and by broad-spectrum AMPAR antagonists. The inhibitor of GluA2 clathrin-mediated endocytosis Tat-GluA2-3Y peptide and the dynamin-dependent endocytosis inhibitor dynasore both significantly inhibited APSPs. The CK2 antagonist DRB also inhibited APSPs and, like hypoxic treatment, caused opposite regulation of A1R and A2AR surface expression. APSPs were abolished when calcium-permeable AMPAR (CP-AMPAR) antagonist (IEM or philanthotoxin) or non-competitive AMPAR antagonist perampanel was applied 5 min after hypoxia. In contrast, perampanel, but not CP-AMPAR antagonists, abolished APSPs when applied during hypoxia/reperfusion. To test for neuronal viability after hypoxia, propidium iodide staining revealed significant neuroprotection of hippocampal CA1 pyramidal neurons when pretreated with Tat-GluA2-3Y peptide, CK2 inhibitors, dynamin inhibitor, CP-AMPAR antagonists (applied 5 min after hypoxia), and perampanel (either at 5 min hypoxia onset or during APSP). These results suggest that the A1R-CK2-A2AR signaling pathway in hypoxia/reperfusion injury model mediates increased hippocampal synaptic transmission and neuronal damage via calcium-permeable AMPARs that can be targeted by perampanel for neuroprotective stroke therapy.
Junge Geflüchtete gesellschaftlich integrieren
Authors: Scherr Albert , Breit Helen 
Published: January 2021

ZusammenfassungGrundlage des Beitrags ist ein qualitatives Forschungsprojekt zu krisenhaften Entwicklungsverläufen und problematischen Verhaltensweisen bei jungen Geflüchteten. Ausgehend von einer knapp gefassten Kritik politischer und medialer Dramatisierungen, die junge männliche Geflüchtete als bedrohliche Problemgruppe darstellen, werden Überlegungen zu Anforderungen an eine Soziale Arbeit dargestellt, die darauf ausgerichtet ist, eine dem Bedarf junger Geflüchteter angemessene Unterstützung zu ermöglichen.
Female-Type Android’s Drive to Quickly Understand a User’s Concept of Preferences Stimulates Dialogue Satisfaction: Dialogue Strategies for Modeling User’s Concept of Preferences
Authors: Uchida Takahisa , Minato Takashi , Nakamura Yutaka , Yoshikawa Yuichiro , Ishiguro Hiroshi 
Published: January 2021

AbstractThis research develops a conversational robot that stimulates users’ dialogue satisfaction and motivation in non-task-oriented dialogues that include opinion and/or preference exchanges. One way to improve user satisfaction and motivation is by demonstrating the robot’s ability to understand user opinions. In this paper, we explore a method that efficiently obtains the concept of user preferences: likes and dislikes. The concept is acquired by complementing a small amount of user preference data observed in dialogues. As a method for efficient collection, we propose a dialogue strategy that creates utterances with the largest expected complementation. Our experimental results with a female-type android robot suggest that the proposed strategy efficiently obtained user preferences and enhanced dialogue satisfaction. In addition, the strength of user motivation (i.e., long-term willingness to communicate with the android) is only positively correlated with the android’s willingness to understand. Our results not only show the effectiveness of our proposed strategy but also suggest a design theory for dialogue robots to stimulate dialogue motivation, although the current results are derived only from a female-type android.
Characteristics of patients with atrial fibrillation prescribed edoxaban in Belgium and the Netherlands: insights from the ETNA-AF-Europe study
Authors:   the ETNA-AF-Europe principal investigators from Belgium and the Netherlands*, de Vries T. A. C. , Hemels M. E. W. , Cools F. , Crijns H. J. G. M. , Yperzeele L. , Vanacker P. , Blankoff I. , Lancellotti P. , Mairesse G. H. , de Veer A. , Casado Arroyo R. , Catez E. , de Pauw M. , Vanassche T. , de Asmundis C. , Kirchhof P. , De Caterina R. , de Groot J. R. 
Published: January 2021

Abstract
Background
Studies on the use of non-vitamin K antagonist oral anticoagulants in unselected patients with atrial fibrillation (AF) show that clinical characteristics and dosing practices differ per region, but lack data on edoxaban.

Methods
With data from Edoxaban Treatment in routiNe clinical prActice for patients with AF in Europe (ETNA-AF-Europe), a large prospective observational study, we compared clinical characteristics (including the dose reduction criteria for edoxaban: creatinine clearance 15–50 ml/min, weight ≤60 kg, and/or use of strong p‑glycoprotein inhibitors) of patients from Belgium and the Netherlands (BeNe) with those from other European countries (OEC).

Results
Of all 13,639 patients in ETNA-AF-Europe, 2579 were from BeNe. BeNe patients were younger than OEC patients (mean age: 72.3 vs 73.9 years), and had lower CHA2DS2-VASc (mean: 2.8 vs 3.2) and HAS-BLED scores (mean: 2.4 vs 2.6). Patients from BeNe less often had hypertension (61.6% vs 80.4%), and/or diabetes mellitus (17.3% vs 23.1%) than patients from OEC. Moreover, relatively fewer patients in BeNe were prescribed the reduced dose of 30 mg edoxaban (14.8%) than in OEC (25.4%). Overall, edoxaban was dosed according to label in 83.1% of patients. Yet, 30 mg edoxaban was prescribed in the absence of any dose reduction criteria in 36.9% of 30 mg users (5.5% of all patients) in BeNe compared with 35.5% (9.0% of all patients) in OEC.

Conclusion
There were several notable differences between BeNe and OEC regarding clinical characteristics and dosing practices in patients prescribed edoxaban, which are relevant for the local implementation of dose evaluation and optimisation.

Trial registration
NCT02944019; Date of registration 24 October 2016
Setosphlides A–D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10
Authors: Gao Wenbin , Wang Xiaoxia , Chen Fengli , Li Chunqing , Cao Fei , Luo Duqiang 
Published: January 2021

Abstract
Investigation of the entomogenous fungus Setosphaeria rostrate LGWB-10 from Harmonia axyridis led to the isolation of four new isocoumarin derivatives, setosphlides A–D (1–4), and four known analogues (5–8). Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods. The absolute configurations of isocoumarin nucleus for 1–4 were elucidated by their ECD spectra. The C-10 relative configurations for the pair of C-10 epimers (1 and 2) were established by comparing the magnitude of the computed 13C NMR chemical shifts (Δδcalcd.) with the experimental 13C NMR values (Δδexp.) for the epimers. All of the isolated compounds (1–8) were evaluated for their cytotoxicities against four human tumor cell lines MCF-7, MGC-803, HeLa, and Huh-7.

Graphic Abstract
Pin-on-disc study of dry sliding behavior of Co-free HVOF-coated disc tested against different friction materials
Authors: Federici Matteo , Menapace Cinzia , Mancini Alessandro , Straffelini Giovanni , Gialanella Stefano 
Published: January 2021

AbstractThe dry sliding behavior of three commercial friction materials (codenamed FM1, FM2, and FM3) tested against a Co-free cermet coating produced by high-velocity oxy-fuel (HVOF) on gray cast-iron discs is investigated. FM1 is a conventional low-metallic friction material, FM2 is developed for using against HVOF-coated discs, and FM3 is a Cu-free friction material with a low content of abrasives and a relatively high concentration of steel fibers. For the tribological evaluation, they are tested on a pin-on-disc (PoD) test rig against Co-free HVOF-coated discs, with particular attention to the running-in stage, which is fundamental for the establishment of a friction layer between the two mating surfaces, i.e., the pin and disc. The PoD tests are performed at room temperature (RT) and a high temperature (HT) of 300 °C. At RT, all materials exhibit a long running-in stage. At HT, no running-in is observed in FM1 and FM2, whereas a shorter running-in period, with respect to the RT case, is observed in FM3 followed by the attainment of a comparatively high coefficient of friction. At RT, the pin wear is mild in all cases but severe at HT. FM3 shows the lowest wear rate at both temperatures. Moreover, the coated disc shows no wear when sliding against the FM3 friction material. All the results are interpreted considering the microstructural characteristics of the friction layers formed on the sliding surfaces. The findings of the present study provide insights into reducing wear in braking system components and hence reducing environmental particulate matter emissions from their wear, through the use of disc coatings.