bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overtime working patterns and adverse events in work-related suicide cases: hierarchical cluster analysis of national compensation data in Japan (fiscal year 2015–2016)
Authors: Nishimura Yuki , Yamauchi Takashi , Sasaki Takeshi , Yoshikawa Toru , Takahashi Masaya 
Published: September 2021

Abstract
Background
Although various work-related adverse events affect workers’ mental health, the association between long working hours and mental disorders remains unclear. We investigated the characteristics of overtime work and work-related adverse events among all cases of compensated work-related suicide in Japan to empirically reveal the context of the serious consequences.

Methods
We analysed all 167 cases of mental disorders resulting in suicide that were compensated in fiscal year 2015–2016. Hierarchical clustering was applied to the overtime working history. Work-related adverse events were also evaluated as the qualitative aspects of their jobs.

Results
More than half of the cases committed suicide within a month of developing a mental disorder. The Administrative and professional or engineering workers had a higher suicide rate. The clustering analysis revealed chronic long working hours (19%), gradual increase (27%), or rapid increase (25%) in working hours before the onset of a mental disorder. A group of cases with less overwork experienced more interpersonal conflicts.

Conclusion
This is the first study to employ a clustering technique to objectively reveal the actual working patterns behind suicide. The patterns of working overtime before the onset of mental disorders varied considerably among the cases. Taking the transition of working overtime into account may provide clearer insight into the relationship between long working hours and workers’ mental health. These results highlight the need for countermeasures especially for causes of chronic overworking, drastic increases in working hours, and interpersonal conflicts to prevent work-related suicide.
Short- and long-term follow-up of patients with non-neoplastic esophageal perforation
Authors: Brinkmann Sebastian , Knepper Laura , Fuchs Hans , Hoelscher Arnulf , Kuhr Kathrin , dos Santos Daniel Pinto , Plum Patrick , Chon Seung-Hun , Bruns Christiane , Schroeder Wolfgang , Leers Jessica 
Published: September 2021

Abstract

Purpose
Esophageal perforation is associated with high morbidity and mortality. In addition to surgical treatment, endoscopic endoluminal stent placement and endoscopic vacuum therapy (EVT) are established methods in the management of this emergency condition. Although health-related quality of life (HRQoL) is becoming a major issue in the evaluation of any therapeutic intervention, not much is known about HRQoL, particularly in the long-term follow-up of patients treated for non-neoplastic esophageal perforation with different treatment strategies. The aim of this study was to evaluate patients’ outcome after non-neoplastic esophageal perforation with focus on HRQoL in the long-term follow-up.

Methods
Patients treated for non-neoplastic esophageal perforation at the University Hospital Cologne from January 2003 to December 2014 were included. Primary outcome and management of esophageal perforation were documented. Long-term quality of life was assessed using the Gastrointestinal Quality of Life Index (GIQLI), the Health-Related Quality of Life Index (HRQL) for patients with gastroesophageal reflux disease (GERD), and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires for general and esophageal specific QoL (QLQ-C30 and QLQ-OES18).

Results
Fifty-eight patients were included in the study. Based on primary treatment, patients were divided into an endoscopic (n = 27; 46.6%), surgical (n = 20; 34.5%), and a conservative group (n = 11; 19%). Short- and long-term outcome and quality of life were compared. HRQoL was measured after a median follow-up of 49 months. HRQoL was generally reduced in patients with non-neoplastic esophageal perforation. Endoscopically treated patients showed the highest GIQLI overall score and highest EORTC general health status, followed by the conservative and the surgical group.

Conclusion
HRQoL in patients with non-neoplastic esophageal perforation is reduced even in the long-term follow-up. Temporary stent or EVT is effective and provides a good alternative to surgery, not only in the short-term but also in the long-term follow-up.
Two-field formulations for isogeometric Reissner–Mindlin plates and shells with global and local condensation
Authors: Kikis G. , Klinkel S. 
Published: September 2021

AbstractIn this paper, mixed formulations are presented in the framework of isogeometric Reissner–Mindlin plates and shells with the aim of alleviating membrane and shear locking. The formulations are based on the Hellinger-Reissner functional and use the stress resultants as additional unknowns, which have to be interpolated in appropriate approximation spaces. The additional unknowns can be eliminated by static condensation. In the framework of isogeometric analysis static condensation is performed globally on the patch level, which leads to a high computational cost. Thus, two additional local approaches to the existing continuous method are presented, an approach with discontinuous stress resultant fields at the element boundaries and a reconstructed approach which is blending the local control variables by using weights in order to compute the global ones. Both approaches allow for a static condensation on the element level instead of the patch level. Various numerical examples are investigated in order to verify the accuracy and effectiveness of the different approaches and a comparison to existing elements that include mechanisms against locking is carried out.
Causes and consequences of long-term groundwater overabstraction in Jordan
Authors: Brückner Florian , Bahls Rebecca , Alqadi Mohammad , Lindenmaier Falk , Hamdan Ibraheem , Alhiyari Mohammad , Atieh Ala’a 
Published: September 2021

AbstractIn 2017, a comprehensive review of groundwater resources in Jordan was carried out for the first time since 1995. The change in groundwater levels between 1995 and 2017 was found to be dramatic: large declines have been recorded all over the country, reaching more than 100 m in some areas. The most affected areas are those with large-scale groundwater-irrigated agriculture, but areas that are only used for public water supply are also affected. The decrease of groundwater levels and saturated thickness poses a growing threat for drinking water supply and the demand has to be met from increasingly deeper and more remote sources, causing higher costs for drilling and extraction. Groundwater-level contour lines show that groundwater flow direction has completely reversed in some parts of the main aquifer. Consequently, previously established conceptual models, such as the concept of 12 “groundwater basins” often used in Jordan should be revised or replaced. Additionally, hydraulic conditions are changing from confined to unconfined; this is most likely a major driver for geogenic pollution with heavy metals through leakage from the overlying bituminous aquitard. Three exemplary case studies are presented to illustrate and discuss the main causes for the decline of the water tables (agriculture and population growth) and to show how the results of this assessment can be used on a regional scale.
Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering
Authors: Liu Yongliang , Patra Barunava , Singh Sanjay Kumar , Paul Priyanka , Zhou Yan , Li Yongqing , Wang Ying , Pattanaik Sitakanta , Yuan Ling 
Published: September 2021

AbstractPlants synthesize a vast array of specialized metabolites that primarily contribute to their defense and survival under adverse conditions. Many of the specialized metabolites have therapeutic values as drugs. Biosynthesis of specialized metabolites is affected by environmental factors including light, temperature, drought, salinity, and nutrients, as well as pathogens and insects. These environmental factors trigger a myriad of changes in gene expression at the transcriptional and posttranscriptional levels. The dynamic changes in gene expression are mediated by several regulatory proteins that perceive and transduce the signals, leading to up- or down-regulation of the metabolic pathways. Exploring the environmental effects and related signal cascades is a strategy in metabolic engineering to produce valuable specialized metabolites. However, mechanistic studies on environmental factors affecting specialized metabolism are limited. The medicinal plantCatharanthus roseus(Madagascar periwinkle) is an important source of bioactive terpenoid indole alkaloids (TIAs), including the anticancer therapeutics vinblastine and vincristine. The emerging picture shows that various environmental factors significantly alter TIA accumulation by affecting the expression of regulatory and enzyme-encoding genes in the pathway. Compared to our understanding of the TIA pathway in response to the phytohormone jasmonate, the impacts of environmental factors on TIA biosynthesis are insufficiently studied and discussed. This review thus focuses on these aspects and discusses possible strategies for metabolic engineering of TIA biosynthesis.Purpose of workCatharanthus roseusis a rich source of bioactive terpenoid indole alkaloids (TIAs). The objective of this work is to present a comprehensive account of the influence of various biotic and abiotic factors on TIA biosynthesis and to discuss possible strategies to enhance TIA production through metabolic engineering.
Bifurcations of quasi-periodic solutions from relative equilibria in the Lennard–Jones 2-body problem
Authors: Strzelecki Daniel 
Published: September 2021

AbstractWe propose the general method of proving the bifurcation of new solutions from relative equilibria in N-body problems. The method is based on a symmetric version of Lyapunov center theorem. It is applied to study the Lennard–Jones 2-body problem, where we have proved the existence of new periodic or quasi-periodic solutions.
Operationalizing Intentionality in Primate Communication: Social and Ecological Considerations
Authors: Rodrigues Evelina D. , Fröhlich Marlen 
Published: September 2021

AbstractAn intentional transfer of information is central to human communication. When comparing nonhuman primate communication systems to language, a critical challenge is to determine whether a signal is used in intentional, goal-oriented ways. As it is not possible to directly observe psychological states in any species, comparative researchers have inferred intentionality via behavioral markers derived from studies on prelinguistic human children. Recent efforts to increase consistency in nonhuman primate communication studies undervalue the effect of possible sources of bias: some behavioral markers are not generalizable across certain signal types (gestures, vocalizations, and facial expressions), contexts, settings, and species. Despite laudable attempts to operationalize first-order intentionality across signal types, a true “multimodal” approach requires integration across their sensory components (visual-silent, contact, audible), as a signal from a certain type can comprise more than one sensory component. Here we discuss how the study of intentional communication in nonlinguistic systems is hampered by issues of reliability, validity, consistency, and generalizability. We then highlight future research avenues that may help to understand the use of goal-oriented communication by opting, whenever possible, for reliable, valid, and consistent behavioral markers, but also taking into account sampling biases and integrating detailed observations of intraspecific communicative interactions.
From the Sequence of the Sun-Goddess (bhānavīkrama) to Time-Consumption (kālagrāsa): Some Notes on the Development of the Śākta Doctrine of the Twelve Kālīs
Authors: Wenta Aleksandra 
Published: September 2021

AbstractThe doctrine of the twelve Kālīs is one of the earliest developments of the Śākta tradition of the Kālīkula/Kālīkrama/Mahānaya and it is well known in the later exegetical works of Abhinavagupta (10th–11th c.), Kṣemarāja (11th c.), and Maheśvarānanda (13th–14th c.). Although the twelve Kālīs have been treated to some extent in secondary literature, a systematic study of the development and reception of this doctrine has not been undertaken yet. This is mainly due to the fact that most of the Kālīkula scriptures are available in manuscript form, and methodical analysis of their contents remains a desideratum. In this article, I intend to examine selected tantric scriptures teaching the doctrine of the twelve Kālīs, focusing on the development of the constituent elements of this doctrine, as they appear in different tantric sources. This article traces the origins of the twelve Kālīs to the esoteric teaching of the Sun-Goddess, linked to the tradition of the Skeleton of Kālī (kālīkaṅkāla/kaṅkāla). It will argue that in the subsequent phase of the doctrine’s development the solar context gradually diminished and an emphasis on the twelve goddesses’ function as the destroyers of time became more and more pronounced. This tendency, in turn, influenced the codification of the twelve Kālīs as the fully-fledged doctrine of time-consumption (kālagrāsa), popular in the Trika and the Trika-inspired Krama sources.
Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population
Authors: Iwanicki Tomasz , Balcerzyk Anna , Kazek Beata , Emich-Widera Ewa , Likus Wirginia , Iwanicka Joanna , Kapinos-Gorczyca Agnieszka , Kapinos Maciej , Jarosz Alicja , Grzeszczak Władysław , Górczyńska-Kosiorz Sylwia , Niemiec Paweł 
Published: September 2021

AbstractThe aim of the study was to perform family-based association analysis of PRKCB1, CBLN1 and KCNMB4 gene polymorphisms and autism disorder. We comprised 206 Caucasian children with autistic spectrum disorder (ASD) and their biological parents. In transmission/disequilibrium test we observed that T-allele of the rs198198 polymorphism of the PRKCB1 gene was more often transmitted to affected children in the male subgroup (p = 0.010). Additionally, the T carrier state was significantly associated with hypotonia (p = 0.048). In the female subgroup, the T-allele carriers more often showed more mobile/vital behavior (p = 0.046). In conclusion, our study showed that the rs198198 of the PRKCB1 gene may be associated with ASD in men and with some features characteristic for the disorder.
The benefits of need satisfaction depend on their relative importance for people with a unidimensional identity: an idiographic analysis
Authors: Glendinning Freya , Woodman Tim , Hardy Lew , Ong Chin Wei 
Published: September 2021

AbstractSelf-determination theory proposes that the satisfaction of basic psychological needs is equally beneficial for everyone – the Universal Hypothesis. Equally, there are intra-individual differences in how the satisfaction of differentially important needs might be differentially beneficial, which we term the Intra-individual Hypothesis. We aimed to reconcile these positions. Across four cross-sectional studies (ns = 300 rock climbers, 323 sportspeople, 394 UK and Chinese adults, 320 UK adults), we investigated the needs of individuals with varying dimensions to their identity, and their motivation and self-esteem. In Studies 1, 2, and 4, when individuals strongly related their sense of identity to investment in a specific activity, the association between need satisfaction and self-esteem (and motivation in Studies 1–2) depended on their intra-individual need importance, supporting the Intra-individual Hypothesis. In Studies 3 and 4, for individuals with a multidimensional identity, the association between need satisfaction and self-esteem did not depend on the importance of each need, supporting the Universal Hypothesis. The satisfaction of basic psychological needs is not always uniform in its link with motivation and well-being. The degree to which individuals have a unidimensional or multidimensional self-concept appears fruitful in predicting the relative value of the Universal Hypothesis and the Intra-individual Hypothesis.
Commentary: how person-centred is pharmaceutical care?
Authors: Gyllensten Hanna , Fuller Joanne M. , Östbring Malin Johansson 
Published: September 2021

AbstractHealth systems in many countries are currently undergoing an evolution towards more person-centred care. However, an overview of the literature shows that there is little or no guidance available on how to apply person-centred care to pharmaceutical care and clinical pharmacy practices. In this paper we apply a model for person-centred care created by a national multidisciplinary research centre in Gothenburg, Sweden, to the clinical work tasks of outpatient and inpatient pharmacists and describe how pharmaceutical care can become more person-centred.
Gender differences in work-related high mobility differentiated by partnership and parenthood status
Authors: Wachter Isabelle , Holz-Rau Christian 
Published: September 2021

AbstractThe income situation and the division of labor in households, which are closely related to occupational mobility, are central aspects of the debate on gender equality. Women have shorter commuting times and distances than men and spend fewer nights away from their main place of residence for work-related reasons. Various studies attribute these gender differences to a gendered division of labor and the associated greater involvement of women in household tasks and childcare. Consequently, studies investigating these gender differences focus primarily on employees in relationships and the associated intra-couple interactions, while little attention is paid to singles. Based on the German Family Panel (pairfam) this research aims to broaden the scope of interpretation and examines gender differences in work-related high mobility among employees in partnerships with and without children and among singles. Logistic regression models including gender interaction terms show that gender differences exist not only among employees with partners (and children), but also among singles. The results highlight that gender differences in high mobility are due to factors related to relationships and parenthood, as well as from other factors. Gender differences in high mobility are thus not merely the result of negotiation processes or of (patriarchal) power structures in relationships and gendered labor division. They are also related to gendered occupational segregation and economic disparities and internalized gender preferences that are independent of partnership and parenthood.
Does R&D Expenditure Boost Economic Growth in Lagging Regions?
Authors: Celli Viviana , Cerqua Augusto , Pellegrini Guido 
Published: September 2021

AbstractWe assess the impact of the EU Regional Policy on regional economic growth by applying a new evaluation strategy, which integrates mediation analysis with a quasi-experimental framework. Using the R&D expenditure as an indicator of innovation capability, we evaluate how much of the total effect of the EU Regional Policy is due to R&D in the poorest EU regions. Consistently with the previous literature, we found a positive impact of the overall policy on economic growth, but, among the convergence regions, those investing a higher proportion of funds in R&D have the same convergence rate as regions investing more in other priorities. These findings confirm that the EU Regional Policy played an important role in the economic recovery of the poorest regions in the aftermath of the Great Recession. However, focusing resources on R&D does not seem to provide additional economic benefits, at least in the short run.
Independent or Dependent? European Labour Statistics and Their (In)ability to Identify Forms of Dependency in Self-employment
Authors: Bozzon Rossella , Murgia Annalisa 
Published: September 2021

AbstractIn the studies on labour market change and transformation of employment relations, the growth of new forms of self-employment, including platform work, has raised a broad debate about how to define, classify, and analyse the wide range of positions within the heterogeneous category of self-employed workers. This article analyses the emergent methodologies used in European comparative labour statistics to identify forms of dependency in self-employment. Using the 6th wave of the 2015 European Working Condition Survey and the 2017 ad hoc module on self-employment from the European Labour Force Survey, this article discusses how the representation of dependent self-employment changes by adopting a different operationalization of economic and operational dependency. Findings show how different indicators of dependency change the representation of self-employment in different economic sectors, affecting our understanding of the transformation of working arrangements within self-employment and the boundaries between employment and self-employment.
The Best Years of Older Europeans’ Lives
Authors: Álvarez Begoña 
Published: September 2021

AbstractThis paper offers new evidence on the life-cycle pattern of happiness. A novelty of the analysis is that it exploits information on the period individuals recall as the happiest in their lives. Data come from SHARELIFE 2008/09, a retrospective life survey conducted in 13 European countries among individuals aged 50 or more. Using this information, I build a longitudinal data set that extends across the whole lifespan of respondents. The probability of living a happiest year in life at each age is estimated through a conditional fixed effects logit model. Results show that the likelihood of living the happiest period in life exhibits a concave relationship with age, with a turning point at about 30–34 years and a decreasing trend from that point onward. Retrospectively, midlife is not perceived as the least likely happiest period in life. These patterns persist even after controlling for usual correlates of subjective well-being, and they are rather stable across cohorts and genders despite presenting certain variability across European countries.
Emotionally engaged or feeling anxious and cynical? School experiences and links to school achievement among Finland-Swedish general and special education students
Authors: Palmgren Marina , Pyhältö Kirsi , Pietarinen Janne , Sullanmaa Jenni , Soini Tiina 
Published: September 2021

AbstractThe aim of the study was to enhance understanding of how seventh graders vary in emotional engagement and experienced well-being at school in terms of anxiety and cynicism. The two profiles were explored, and comparisons were made between students in general education and those in special education. The study participants comprised 119 Finland–Swedish students from five secondary schools. Four emotional-engagement and well-being profiles were identified based on cluster analysis. The students with the most typical profile were moderately engaged in teacher-student interaction and emotionally highly engaged in peer interaction, combined with a low risk of anxiety and cynicism. The profiles showed no statistically significant differences regarding gender and school achievement. However, there were differences between students in special education and those in general education. In Finland, Swedish –speaking Finns are a language minority group. Swedish has official language status in Finland. Compared to many other language minority groups they can be considered somewhat exceptional, since according to many welfare indicators they tend to do better than the general population. There are a few studies on differences between Swedish and Finnish– speaking students’ school experiences in Finland, however, so far studies exploring Swedish- speaking general and special education students’ emotional engagement and study well-being in terms of anxiety and cynicism have been scarce.