bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study
Authors: Chen Yu-Yen , Chen Hsin-Hua , Lo Tzu-Chen , Chou Pesus 
Published: August 2021

Objective
To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.

Methods
In Taiwan’s national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. The characteristics of the two groups were compared. Using multivariate Cox regression, hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses, separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were calculated.

Results
The mean age of the study cohort was 50.2 ± 17.2 years. Hypertension, diabetes, hyperlipidaemia and obesity were more prevalent in the uveitis group (all p < 0.0001). The hazard of psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than in the non-uveitis group (p < 0.0001); this increased risk persisted after adjustment for confounders [adjusted HR = 1.41; 95% confidence interval (CI), 1.33–1.48]. Adjusted HRs showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28–1.44) to severe psoriasis (1.59; 95% CI, 1.30–1.94) and psoriatic arthritis (1.97; 95% CI, 1.60–2.42).

Conclusions
This nationwide population-based cohort study revealed that patients with uveitis have an increased risk of subsequent psoriasis or psoriatic arthritis development.
Prevalence of short interpregnancy interval and its associated factors among pregnant women in Debre Berhan town, Ethiopia
Authors: Mamo Hana , Dagnaw Abinet , Sharew Nigussie Tadesse , Brhane Kalayu , Kotiso Kehabtimer Shiferaw 
Published: August 2021

Background
Short inter-pregnancy interval is an interval of <24 months between the dates of birth of the preceding child and the conception date of the current pregnancy. Despite its direct effects on the perinatal and maternal outcomes, there is a paucity of evidence on its prevalence and determinant factors, particularly in Ethiopia. Therefore, this study assessed the prevalence and associated factors of short inter-pregnancy interval among pregnant women in Debre Berhan town, Northern Ethiopia.

Methods
A community based cross-sectional study was conducted among a randomly selected 496 pregnant women in Debre Berhan town from February 9 to March 9, 2020. The data were collected by using an interviewer-administered questionnaire and analyzed using STATA (14.2) statistical software. To identify the predictors of short inter-pregnancy interval, multivariable binary logistic regression was fitted and findings are presented using adjusted odds ratio (AOR) with 95% confidence interval (CI).

Result
The overall prevalence of short inter-pregnancy interval (<24 months) among pregnant women was 205 (40.9%). Being over 30 years of age at first birth (AOR = 3.50; 95% CI: 2.12–6.01), non-use of modern contraceptive (AOR = 2.51; 95% CI: 1.23–3.71), duration of breastfeeding for less than 12 months (AOR = 2.62; 95% CI: 1.32–5.23), parity above four (AOR = 0.31; 95% CI: 0.05–0.81), and unintended pregnancy (AOR = 5.42; 95% CI: 3.34–9.22) were independently associated factors with short inter-pregnancy interval.

Conclusion
Despite the public health interventions being tried in the country, the prevalence of short inter-pregnancy interval in this study is high. Therefore, it implies that increasing contraceptive use and encouraging optimal breastfeeding might help in the efforts made to avert the problem.
Thermal-hydraulic performance prediction of two new heat exchangers using RBF based on different DOE
Authors: Yu Chulin , Wang Youqiang , Zhang Haiqing , Gao Bingjun , He Yin 
Published: August 2021

Abstract
Thermal performance prediction with high precision and low cost is always the need for designers of heat exchangers. Three typical design of experiments (DOE) known as Taguchi design method (TDM), Uniform design method (UDM), and Response surface method (RSM) are commonly used to reduce experimental cost. The radial basis function artificial neural network (RBF) based on different DOE is used to predict the thermal performance of two new parallel-flow shell and tube heat exchangers. The applicability and expense of ten different prediction methods (RBF + TDML9, RBF + TDML18, RBF + UDM, RBF + TDML9 + UDM, RBF + TDML18 + UDM, RBF + RSM, RBF + RSM + TDML9, RBF + RSM + TDML18, RBF + RSM + UDM, RSM) are discussed. The results show that the RBF + RSM is a very efficient method for the precise prediction of thermal-hydraulic performance: the minimum error is 2.17% for Nu and 5.30% for f. For RBF, it is not true that the more of train data, the more precision of the prediction. The parameter “spread” of RBF should be adjusted to optimize the prediction results. The prediction using RSM only can also obtain a good balance between precision and time cost with a maximum prediction error of 14.52%.
Charge identification of fragments with the emulsion spectrometer of the FOOT experiment
Authors: Galati Giuliana , Alexandrov Andrey , Alpat Behcet , Ambrosi Giovanni , Argirò Stefano , Diaz Raul Arteche , Bartosik Nazar , Battistoni Giuseppe , Belcari Nicola , Bellinzona Elettra , Biondi Silvia , Bisogni Maria Giuseppina , Bruni Graziano , Carra Pietro , Cerello Piergiorgio , Ciarrocchi Esther , Clozza Alberto , Colombi Sofia , Guerra Alberto Del , De Simoni Micol , Di Crescenzo Antonia , Di Ruzza Benedetto , Donetti Marco , Dong Yunsheng , Durante Marco , Faccini Riccardo , Ferrero Veronica , Fiandrini Emanuele , Finck Christian , Fiorina Elisa , Fischetti Marta , Francesconi Marco , Franchini Matteo , Franciosini Gaia , Galli Luca , Gentile Valerio , Giraudo Giuseppe , Hetzel Ronja , Iarocci Enzo , Ionica Maria , Iuliano Antonio , Kanxheri Keida , Kraan Aafke Christine , Lante Valeria , La Tessa Chiara , Laurenza Martina , Lauria Adele , Torres Ernesto Lopez , Marafini Michela , Massimi Cristian , Mattei Ilaria , Mengarelli Alberto , Moggi Andrea , Montesi Maria Cristina , Morone Maria Cristina , Morrocchi Matteo , Muraro Silvia , Murtas Federica , Pastore Alessandra , Pastrone Nadia , Patera Vincenzo , Pennazio Francesco , Placidi Pisana , Pullia Marco , Raffaelli Fabrizio , Ramello Luciano , Ridolfi Riccardo , Rosso Valeria , Sanelli Claudio , Sarti Alessio , Sartorelli Gabriella , Sato Osamu , Savazzi Simone , Scavarda Lorenzo , Schiavi Angelo , Schuy Christoph , Scifoni Emanuele , Sciubba Adalberto , Sécher Alexandre , Selvi Marco , Servoli Leonello , Silvestre Gianluigi , Sitta Mario , Spighi Roberto , Spiriti Eleuterio , Sportelli Giancarlo , Stahl Achim , Tioukov Valeri , Tomassini Sandro , Tommasino Francesco , Toppi Marco , Traini Giacomo , Valle Serena Marta , Vanstalle Marie , Villa Mauro , Weber Ulrich , Zarrella Roberto , Zoccoli Antonio , De Lellis Giovanni 
Published: August 2021

Abstract
The FOOT (FragmentatiOn Of Target) experiment is an international project designed to carry out the fragmentation cross-sectional measurements relevant for charged particle therapy (CPT), a technique based on the use of charged particle beams for the treatment of deep-seated tumors. The FOOT detector consists of an electronic setup for the identification of

Z
≥
3

Z\ge 3

fragments and an emulsion spectrometer for

Z
≤
3

Z\le 3

fragments. The first data taking was performed in 2019 at the GSI facility (Darmstadt, Germany). In this study, the charge identification of fragments induced by exposing an emulsion detector, embedding a

C

2

H

4

{{\rm{C}}}_{2}{{\rm{H}}}_{4}

target, to an oxygen ion beam of 200 MeV/n is discussed. The charge identification is based on the controlled fading of nuclear emulsions in order to extend their dynamic range in the ionization response.
Comprehensive Physical Activity Assessment During U.S. Army Basic Combat Training
Authors: Alemany Joseph A. , Pierce Joseph R. , Bornstein Daniel B. , Grier Tyson L. , Jones Bruce H. , Glover Saundra H. 
Published: August 2021

Abstract
Alemany, JA, Pierce, JR, Bornstein, DB, Grier, TL, Jones, BH, and Glover, SH. Comprehensive physical activity assessment during U.S. Army Basic Combat Training. J Strength Cond Res 36(12): 3505–3512, 2022—Physical activity (PA) volume, intensity, and qualitative contextual information regarding activity type and loads carried are limited during U.S. Army Basic Combat Training (BCT). The purpose of this study was to characterize daily (05:00–20:00 hours) PA during BCT using a comprehensive approach. During 2 10-week BCT cycles (n = 40 trainees per cycle), pedometers, accelerometers, and direct observation were used to estimate daily step count, PA volume, and intensity. Physical activity intensity was categorized by metabolic equivalents (METs) such as “sedentary” (1–2 METs), “light” (2–3 METs), “moderate” (3–6 METs), or “vigorous” (≥6 METs). Daily PA data were analyzed longitudinally using linear mixed models, with significance set at p ≤ 0.05. The mean daily step count was 13,459 ± 4,376 steps, and the mean daily accelerometer-assessed PA volume and intensity were as follows: sedentary: 505 ± 98 minutes, light: 190 ± 78 minutes, moderate: 168 ± 51 minutes, and vigorous: 14 ± 14 minutes, with no differences between cycles for all measures (p > 0.50). Cumulative time on feet (∼50%) and sitting (20–25%) accounted for most daily activity types during both cycles. Trainees, on average, carried between 3 and 9 kg, and ≥9 kg, for 60% and 10% of the monitored day, respectively. Basic Combat Training's physical demands are high, where trainees achieved 1.7 to 2.7 times greater daily ambulation and 6 times the recommended weekly moderate-to-vigorous PA compared with civilian counterparts and performed weight-bearing load carriage for nearly half of the day. Basic Combat Training-associated PA may increase injury risk among trainees unaccustomed to arduous PA and exercise. Implementing national PA policies to improve physical fitness and facilitate acclimatization to BCT's high physical demands could reduce public health burdens and military nonreadiness.
Radiographic evaluation of non-syndromic third molar agenesis in two Mediterranean populations
Authors: Reda Bachar , Fantin Federica , Berro Khetam , Noujeim Ziad , El-Outa Abbass 
Published: August 2021

Background and aims. Third molar agenesis is a common finding across the world. Many studies have assessed third molar agenesis in different ethnicities and populations. However, there are no such studies in the Italian and Lebanese populations. Our study aims to evaluate the prevalence of third molar agenesis and study the pattern and distribution of agenesis in between genders in Italian and Lebanese Mediterranean populations and compare these findings with other global and Mediterranean populations’ studies.
Methods. Retrospective chart review was conducted based on the history and orthopantomograms of adolescents aged 12 to 21 years to assess the agenesis of third molars in a sample of Italian and Lebanese populations by two experienced dental surgeons twice within 1 month. Descriptive and comparative tests were used to analyze the patterns of ageneses and make comparisons between the two samples.
Results. 23.4% of the studied sample had at least one third molar agenesis; females were more likely to have two or more third molar agenesis than males, but neither sex predisposition for single third-molar agenesis was recorded. Both the Italian and Lebanese subgroups seemed to have similar results. The maxillary right third molar was the most common third molar to be absent. Two or more ageneses were more common than one third molar agenesis.
Conclusion. Our Mediterranean population results fall within the range reported in the literature and corroborate with the global average prevalence.
The impact of diabetes mellitus on the anti-tuberculous treatment outcome: a series of cases from the Republic of Moldova
Authors: Lesnic Evelina , Malic Alina , Tafuni Ovidiu 
Published: August 2021

Background and aims. The Republic of Moldova ranks among the European Region countries with the highest global incidence of tuberculosis. Almost 5% of the cases with pulmonary TB had been diagnosed with DM in 2017. The aim of this study was to assess the impact of diabetes mellitus on the anti-tuberculosis treatment effectiveness for the improvement of the disease outcome.
Methods. A retrospective, longitudinal and case-control study, which included a total number of 252 patients diagnosed with pulmonary tuberculosis and distributed into a study group of 93 patients diagnosed with diabetes mellitus and a control group of 159 patients without glycemic disorders was performed. The statistical analysis was performed using EpiInfo software. The statistical analysis of the differences between normally distributed continuous variables was tested with the Student T-test.
Results. Based on the collected data we established that the majority of the patients with glycemic disorders were diagnosed with the type 2 diabetes, associated with hyperglycemia and in half of them complications of diabetes were revealed. The age older 55 years and the low economical state were common characteristics of the diabetic patients. Tuberculosis was detected in every second diabetic patient through the radiological screening compared with the passive detection of most of the non-diabetic patients. The anti-tuberculosis treatment outcome was endangered by a higher rate of the adverse drug events in patients with diabetes, which contributed to death in 15%, lost to follow-up 7%, and therapeutic failure in 6%.
Conclusions. The anti-tuberculous treatment outcome in patients diagnosed with tuberculosis and diabetes mellitus was significantly diminished by glycemic disorders, history of the previous anti-tuberculous treatment and adverse drug reactions. Individualized therapeutic approach to tuberculosis could improve the treatment effectiveness.
Volumetric data of normal nucleus accumbens from magnetic resonance imaging scans
Authors: Birbilis Theodosios , Siozopoulos Achilleas , Fiska Aliki , Deftereos Savas , Kaldoudi Eleni , Karagiannis Vassilios , Thomaidis Vassilios 
Published: August 2021

Backgrounds and aims. The nucleus accumbens (AcN) belongs to the ventral striatum and it is involved in several neuropsychiatric disorders. In contrast to other subcortical structures, the number of morphometric studies that concern the healthy nucleus is limited. This study aims to investigate the normal volumetric data of the AcN as derived from a large number of manually segmented magnetic resonance imaging (MRI) scans.
Methods. The measurements were performed in 106 MRI scans of healthy adults. The resulting volumes have been analyzed for differences related to hemisphere, sex and age.
Results. The mean AcN volume was estimated at 473.3 mm3 (SD=±106.8). A slight interhemispheric difference in favor of the left side was found, the value of which was, however, within the limits of the method error. There were no sexual dimorphism signs concerning both the raw and the normalized volumes. A negative correlation between volumes and age was observed only in males.
Conclusions. The study provides normal volumetric data of the AcN, useful in the conduct of comparative imaging and post-mortem studies in pathological conditions
COMPARATIVE ANALYSIS OF THE EFFECTS OF CURCUMIN AND EPICATECHIN ON THE VITALITY OF ROOSTER SPERMATOZOA
Authors: Benko Filip , Ďuračka Michal , Kováč Ján , Lukáč Norbert , Tvrdá Eva 
Published: August 2021

The objective of our study was to assess the effects of two selected antioxidants (curcumin - CUR and epicatechin - EPI) on the vitality of rooster spermatozoa. We used semen samples from 10 sexually mature Lohmann light roosters, which were collected from a local farm, diluted in PBS and cultured with different concentrations of CUR and EPI (1, 5, 10, 25, 50 and 100 µmol/L). Motility, membrane and acrosome integrity were analysed after 0, 2 and 24 h of in vitro culture. Sperm motility was evaluated by the computer-assisted sperm analysis (CASA). The membrane integrity was determined by a combination of eosin/nigrosin dyes, and the acrosome integrity was detected by fast green/rose bengal dyes. The data were statistically evaluated using One-way ANOVA and the Dunnet’s test. The results indicate that after 0 h of cultivation all selected parameters stay unchanged. After 2 h significant differences (P<0.0001) were observed in case of the motility and membrane integrity. Following 24 h a significant (P<0.0001) preservation of motility was recorded. The level of membrane damage and acrosome integrity was significantly decreased (P<0.01). Based on our results we may conclude that protective effects of CUR and EPI on the vitality of rooster spermatozoa were observed already after 2 h. This impact was even more dominant after 24 h. CUR showed better effects at lower concentrations (1, 5, and 10 µmol/L) while EPI at higher doses (25 and 50 µmol/L). Our findings could contribute to the potential application of these antioxidants in avian reproduction technologies.
Does Timing Matter?: Timing and Outcomes Among Early Unplanned PICU Transfers
Authors: Nadeau Nicole , Monuteaux Michael C. , Tripathi Jaya , Stack Anne M. , Perron Catherine , Neuman Mark I. 
Published: August 2021

BACKGROUND
Many institutions track early ICU transfers (transfer from an inpatient floor to an ICU within 24 hours of admission) as a marker of quality of emergency department (ED) care. There are limited data evaluating whether patient characteristics or clinical outcomes differ on the basis of timing of ICU transfer within this 24-hour window.

METHODS
We conducted a retrospective cohort study examining all patients ≤21 years old admitted to an inpatient pediatric floor from the ED and subsequently transferred to an ICU within 24 hours of hospitalization. Patient characteristics and clinical outcomes were compared on the basis of timing (0–6 hours, 6–12 hours, 12–24 hours) of ICU transfer. Outcomes assessed included receipt of critical intervention, timing of intervention with respect to transfer, type of intervention received, hospital and ICU length of stay, and mortality at 72 hours and during hospitalization.

RESULTS
A total of 841 patients were transferred to an ICU within 24 hours from admission to a pediatric ward from the ED; 266 patients (32%) transferred within 6 hours of admission, 269 patients (32%) transferred between 6 and 12 hours, and 306 patients (36%) transferred between 12 and 24 hours. Patient characteristics did not materially differ on the basis of timing of ICU transfer, nor did clinical outcomes.

CONCLUSIONS
Among children transferred to an ICU within 24 hours of hospitalization, patient characteristics and clinical outcomes did not materially differ based on the timing of transfer relative to admission from the ED.
Acute Kidney Injury Among Children Admitted With Viral Rhabdomyolysis
Authors: Gardner Hannah M. , Askenazi David J. , Hoefert Jennifer A. , Helton Alexis , Wu Chang L. 
Published: August 2021

BACKGROUND
Infectious etiologies cause a large portion of pediatric rhabdomyolysis. Among pediatric patients with rhabdomyolysis, it is unknown who will develop acute kidney injury (AKI). We sought to test the hypothesis that a viral etiology would be associated with less AKI in children admitted with rhabdomyolysis than a nonviral etiology.

METHODS
In this single-center retrospective cohort study, patients &lt;21 years of age admitted with acute rhabdomyolysis from May 1, 2010, through December 31, 2018, were studied. The primary outcome was development of AKI, defined by using the Kidney Disease: Improving Global Outcomes guidelines. The primary predictor was identification of viral infection by laboratory testing or clinical diagnosis. Covariates included age, sex, race, insurance provider, presence of proteinuria and myoglobinuria, and initial creatinine kinase and serum urea nitrogen. Routine statistics and multivariable logistic modeling were performed via SAS 9.4 (SAS Institute, Inc, Cary, NC).

RESULTS
In total, 319 pediatric patients with rhabdomyolysis were studied. The median age was 13 years. Patients were predominately male (69.9%), non-Hispanic Black (55.2%), and publicly insured (45.1%). We found no difference in the rates of AKI in those with a viral diagnosis versus those without a viral diagnosis (30 of 77 [39.0%] vs 111 of 234 [47.4%]; P = .19). Multivariable analysis revealed that viral diagnosis was not associated with the development of AKI. Patients ≥13 years of age, male patients, and those with proteinuria and elevated serum urea nitrogen on admission had increased odds of developing AKI.

CONCLUSIONS
In our study, viral rhabdomyolysis did not have lower rates of AKI compared with nonviral etiologies of AKI; therefore, providers should consider continued caution in these patients.
Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses: Analysis of ICD-10-CM Transition, 2013–2017
Authors: Ko Jean Y. , Hirai Ashley H. , Owens Pamela L. , Stocks Carol , Patrick Stephen W. 
Published: August 2021

BACKGROUND AND OBJECTIVES
Hospital discharge records remain a common data source for tracking the opioid crisis among pregnant women and infants. The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) transition from the International Classification of Diseases, Ninth Revision, Clinical Modification may have affected surveillance. Our aim was to evaluate this transition on rates of neonatal abstinence syndrome (NAS), maternal opioid use disorder (OUD), and opioid-related diagnoses (OUD with ICD-10-CM codes for long-term use of opioid analgesics and unspecified opioid use).

METHODS
Data from the 2013–2017 Healthcare Cost and Utilization Project’s National Inpatient Sample were used to conduct, interrupted time series analysis and log-binomial segmented regression to assess whether quarterly rates differed across the transition.

RESULTS
From 2013 to 2017, an estimated 18.8 million birth and delivery hospitalizations were represented. The ICD-10-CM transition was not associated with NAS rates (rate ratio [RR]: 0.99; 95% confidence interval [CI]: 0.90–1.08; P = .79) but was associated with 11% lower OUD rates (RR: 0.89; 95% CI: 0.80–0.98; P = .02) and a decrease in the quarterly trend (RR: 0.98; 95% CI: 0.96–1.00; P = .04). The transition was not associated with maternal OUD plus long-term use rates (RR: 0.98; 95% CI: 0.89–1.09; P = .76) but was associated with a 20% overall increase in opioid-related diagnosis rates including long-term and unspecified use (RR: 1.20; 95% CI: 1.09–1.32; P &lt; .001).

CONCLUSIONS
The ICD-10-CM transition did not appear to affect NAS. However, coding of maternal OUD alone may not capture the same population across the transition, which confounds the interpretation of trend data spanning this time period.