bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient, carer, and staff perceptions of robotics in motor rehabilitation: a systematic review and qualitative meta-synthesis
Authors: Laparidou Despina , Curtis Ffion , Akanuwe Joseph , Goher Khaled , Niroshan Siriwardena A. , Kucukyilmaz Ayse 
Published: December 2021

Abstract
Background
In recent years, robotic rehabilitation devices have often been used for motor training. However, to date, no systematic reviews of qualitative studies exploring the end-user experiences of robotic devices in motor rehabilitation have been published. The aim of this study was to review end-users’ (patients, carers and healthcare professionals) experiences with robotic devices in motor rehabilitation, by conducting a systematic review and thematic meta-synthesis of qualitative studies concerning the users’ experiences with such robotic devices.

Methods
Qualitative studies and mixed-methods studies with a qualitative element were eligible for inclusion. Nine electronic databases were searched from inception to August 2020, supplemented with internet searches and forward and backward citation tracking from the included studies and review articles. Data were synthesised thematically following the Thomas and Harden approach. The CASP Qualitative Checklist was used to assess the quality of the included studies of this review.

Results
The search strategy identified a total of 13,556 citations and after removing duplicates and excluding citations based on title and abstract, and full text screening, 30 studies were included. All studies were considered of acceptable quality. We developed six analytical themes: logistic barriers; technological challenges; appeal and engagement; supportive interactions and relationships; benefits for physical, psychological, and social function(ing); and expanding and sustaining therapeutic options.

Conclusions
Despite experiencing technological and logistic challenges, participants found robotic devices acceptable, useful and beneficial (physically, psychologically, and socially), as well as fun and interesting. Having supportive relationships with significant others and positive therapeutic relationships with healthcare staff were considered the foundation for successful rehabilitation and recovery.
Dramatic radiotherapy response of a giant T4 cutaneous squamous cell carcinoma of the scalp with extensive bone destruction: a case report
Authors: Gruber Isabella , Koelbl Oliver 
Published: December 2021

Abstract
Background
Patients with large cutaneous squamous cell carcinoma of the scalp are a treatment challenge. We report a case of dramatic radiotherapy response of a patient with a giant cutaneous squamous cell carcinoma of the scalp with extensive skull destruction and suspected infiltration of the dura mater and superior sagittal sinus. This case is the first report of this kind in the literature that shows that large bone defects can heal with the resolution of tumor and inflammation by secondary intention without surgical reconstruction. We want to put an end to concerns about radiocurability of tumors with extensive bone involvement, and show sustained complete response after definitive radiotherapy and programmed cell death protein-1 inhibiting antibody therapy.

Case presentation
A 74-year-old White man presented with a 7.2 × 6.8 × 5.5 cm painless tumor on the right parietal region of the scalp. Medical imaging revealed widespread destruction of the skull and suspected infiltration of the dura mater and superior sagittal sinus. Biopsies showed cutaneous squamous cell carcinoma (cT4a cN0 cM0, stage IVA). The patient was treated with a total dose of 60 Gy, at 2 Gy per daily fraction with volumetric modulated arc therapy using 6 megavoltage photons. The biologically effective dose (alpha/beta 10 Gy) was 72 Gy. The tumor response correlated with dose received. The patient had a massive tumor necrosis secondary to tumor shrinkage after 18 fractions (36 Gy, biologically effective dose 43.2 Gy). Leakage of cerebrospinal fluid did not occur. Radiotherapy did not hamper the patient’s quality of life. The patient had a clear regression of the initial tumor on the final day of radiotherapy. The bone defect healed by secondary intention without surgical interventions. The patient achieved a complete response with a good cosmetic result after 82 days follow-up. He started a programmed cell death protein-1 inhibiting antibody therapy with cemiplimab 2 months after radiotherapy, and is now at 10 months follow-up without evidence of recurrence.

Conclusion
Definitive radiotherapy is a safe and highly effective therapy for giant tumors of the scalp with extensive bone destruction. We report a sustained complete response with a good cosmetic result after secondary wound healing.
Nonsurgical Management of Thyroid Nodules: The Role of Ablative Therapies
Authors: Stan Marius N , Papaleontiou Maria , Schmitz John J , Castro M Regina 
Published: December 2021

Abstract

Context
After a thorough evaluation most thyroid nodules are deemed of no clinical consequence and can be observed. However, when they are compressive, toxic, or involved by papillary thyroid carcinoma surgery or radioactive iodine (RAI) (if toxic) are the treatments of choice. Both interventions can lead to hypothyroidism and other adverse outcomes (eg, scar, dysphonia, logistical limitation with RAI). Active surveillance might be used for papillary thyroid microcarcinoma (PTMC) initially, but anxiety leads many cases to surgery later. Several ablative therapies have thus evolved over the last few years aimed at treating these nodules while avoiding described risks.

Cases
We present 4 cases of thyroid lesions causing concern (compressive symptoms, thyrotoxicosis, anxiety with active surveillance of PTMC). The common denominator is patients’ attempt to preserve thyroid function, bringing into focus percutaneous ethanol injection (PEI) and thermal ablation techniques (radiofrequency ablation [RFA] being the most common). We discuss the evidence supporting these approaches and compare them with standard therapy, where evidence exists. We discuss additional considerations for the utilization of these therapies, their side-effects, and conclude with a simplified description of how these procedures are performed.

Conclusion
Thermal ablation, particularly RFA, is becoming an attractive option for managing a subgroup of solid thyroid nodules, while PEI has a role in managing thyroid cysts and a select group of PTMC. Their role in the algorithm of thyroid nodule management is still being refined and technical expertise will be essential to reproduce the reported results into everyday practice.
Hypothalamic Kisspeptin Neurons and the Control of Homeostasis
Authors: Rønnekleiv Oline K , Qiu Jian , Kelly Martin J 
Published: December 2021

AbstractHypothalamic kisspeptin (Kiss1) neurons provide indispensable excitatory transmission to gonadotropin-releasing hormone (GnRH) neurons for the coordinated release of gonadotropins, estrous cyclicity, and ovulation. But maintaining reproductive functions is metabolically demanding so there must be a coordination with multiple homeostatic functions, and it is apparent that Kiss1 neurons play that role. There are 2 distinct populations of hypothalamic Kiss1 neurons, namely arcuate nucleus (Kiss1ARH) neurons and anteroventral periventricular and periventricular nucleus (Kiss1AVPV/PeN) neurons in rodents, both of which excite GnRH neurons via kisspeptin release but are differentially regulated by ovarian steroids. Estradiol (E2) increases the expression of kisspeptin in Kiss1AVPV/PeN neurons but decreases its expression in Kiss1ARH neurons. Also, Kiss1ARH neurons coexpress glutamate and Kiss1AVPV/PeN neurons coexpress gamma aminobutyric acid (GABA), both of which are upregulated by E2 in females. Also, Kiss1ARH neurons express critical metabolic hormone receptors, and these neurons are excited by insulin and leptin during the fed state. Moreover, Kiss1ARH neurons project to and excite the anorexigenic proopiomelanocortin neurons but inhibit the orexigenic neuropeptide Y/Agouti-related peptide neurons, highlighting their role in regulating feeding behavior. Kiss1ARH and Kiss1AVPV/PeN neurons also project to the preautonomic paraventricular nucleus (satiety) neurons and the dorsomedial nucleus (energy expenditure) neurons to differentially regulate their function via glutamate and GABA release, respectively. Therefore, this review will address not only how Kiss1 neurons govern GnRH release, but how they control other homeostatic functions through their peptidergic, glutamatergic and GABAergic synaptic connections, providing further evidence that Kiss1 neurons are the key neurons coordinating energy states with reproduction.
Bone Age Maturation and Growth Outcomes in Young Children with CAH Treated with Hydrocortisone Suspension
Authors: Al-Rayess Heba , Addo O Yaw , Palzer Elise , Jaber Mu’taz , Fleissner Kristin , Hodges James , Brundage Richard , Miller Bradley S , Sarafoglou Kyriakie 
Published: December 2021

AbstractBackgroundYoung children with congenital adrenal hyperplasia (CAH) require small doses (0.1-1.25 mg) of hydrocortisone (HC) to control excess androgen production and avoid the negative effects of overtreatment. The smallest commercially available HC formulation, before the recent US Food and Drug Administration approval of HC granules, was a scored 5-mg tablet. The options to achieve small doses were limited to using a pharmacy-compounded suspension, which the CAH Clinical Practice Guidelines recommended against, or splitting tablets into quarters or eighths, or dissolving tablets into water.MethodsCross-sectional chart review of 130 children with classic CAH treated with tablets vs a pharmacy-compounded alcohol-free hydrocortisone suspension to compare growth, weight, skeletal maturation, total daily HC dose, and exposure over the first 4 years of life.ResultsNo significant differences were found in height, weight, or body mass index z-scores at 4 years, and in predicted adult height, before or after adjusting for age at diagnosis and sex. Bone age z-scores averaged 2.8 SDs lower for patients on HC suspension compared with HC tablets (P &lt; 0.001) after adjusting for age at diagnosis and sex. The suspension group received 30.4% lower (P &gt; 0.001) average cumulative HC doses by their fourth birthday.ConclusionsOur data indicate that treatment with alcohol-free HC suspension decreased androgen exposure as shown by lower bone age z-scores, allowed lower average and cumulative daily HC dose compared to HC tablets, and generated no significant differences in SDS in growth parameters in children with CAH at 4 years of age. Longitudinal studies of treating with smaller HC doses during childhood are needed.
Increasing the Learning Result of Early Mathematics Odd and Even Numbers through Montessori "Cards and Counters" Activity: A Quasi-experimental Study
Authors: Darnis Syefriani , Dodd Jaime 
Published: December 2021

Purpose – This study aims to obtain information about the effect of using the Montessori cards and counters’ mathematics activity on learning the result of odd and even numbers of 1 to 10 to the kindergarten students at the age of 4 to 5 years.Design/methods/approach – Quantitative research with a quasi-experimental model of non-equivalent control group design was carried out by applying conventional methods (lectures and giving questions by worksheets) to the control group and applying the Montessori learning model through the use of Cards and Counters apparatus in the experimental group with 30 samples of students, divided into two classes (control class and experiment class) at Kalyca Azzahra School, West Java, Indonesia.Findings – The result showed that students who used the Montessori Mathematics cards and counters achieved higher mathematics odd and even numbers are learning results than those who were not taught with the Montessori approach.Research implications/limitations – This research design used pre-test and post-test. Thus, the treatment results can be more accurate because they can be compared before and after treatment.Practical implications – The use of the Montessori apparatus becomes necessary in introducing early mathematics to children and attracting children’s attention to learn and facilitate teachers in teaching mathematics. Displaying the concrete objects as a medium will help teachers in teaching early mathematics to children. The cards and counters allow children to verify their understanding of the concept by matching the qualitative, concrete, quantitative, or abstract before slowly removing the concrete altogether.Originality/value – This research contributes to understanding learning strategies used in Early Mathematics, Odd and Even Numbers. The Montessori apparatus becomes more natural to understand it by the child’s cognitive development effortlessly.
Paper type Research paper
Child Educational Content on Digital Folklore "Pak Lebai Malang": A Qualitative Content Analysis
Authors: Faeruz Ratna , Rahiem Maila D.H. , Surayyah Madhubala Abdullah Nur , Rahmat Romadhon Dzikri , Sari Dewi Ratna , Rahmatullah Rahmatullah , Rosyada Dede 
Published: December 2021

Purpose – The purpose of this study was to explore child educational content digital folklore on YouTube, and It is used to teach young children about science, language, and values. The unit analysis on this research was the video of Pak Lebai Malang from West Sumatera, Indonesia.Design/methods/approach – The qualitative content analysis method was used in this study. The content analyzed was digital folklore based on the Minangkabau story Pak Lebai Malang. The process began with downloading the video, creating a transcript, taking notes on the text, language, and context, re-watching the video, comparing and contrasting it to the memo, and eliciting evidence from the video.Findings – The data revealed the following ways in which digital folklore on YouTube teaches science, language, and values: 1) digital technology illustrates science concepts with simple-to-understand videos; 2) by repeating the words and visualizing each spoken word, YouTube videos teach children new vocabulary. 3) the characters’ expressions and intonation in the video teach children about social values.Research implications/limitations – This research could serve as a springboard for future research on the use of digital folklores in early childhood classrooms. It is advised that additional research be conducted to improve the interest, effectiveness, and applicability of digital folklore in the early childhood learning process and design more effective programs for teaching science, language, and value to young people children. The study’s drawback is that it analyzes only one video. If it is compared to other videos, it may provide a complete view. Practical implications – This study informs educators on the potential for using digital folklore to teach science, language, and values. It entails the implementation of more creative strategies in early childhood education. Additionally, the study inspires innovative content creators on YouTube to make their videos more relevant to young children’s learning. Additionally, parents may discover that something as simple as a YouTube video could be an incredible resource for their child’s development.Originality/value – The study explains child educational content based on local wisdom. The digital form of Pak Lebai Malang folklore can facilitate accessibility and acceptability.
Paper type Research paper
Teachers' Strategies in Introducing Literacy to Early Childhood: Lesson from Indonesia
Authors: Febiyanti Anita , Kurniati Euis , Emilly Nzunda Ibrahim 
Published: December 2021

Purpose – This study aims to analyze teachers' strategies in introducing literacy to early childhood.Design/methods/approach –The researchers used the case study method. The research subjects are two teachers who teach in early childhood education institutions in Bandung, Indonesia.Findings –The results of this study indicate that in introducing literacy to children, teachers use multiple strategies, such as optimizing role-play activities, stimulation through active teacher conversations that encourage children to communicate (rich teacher talk), utilizing the use of big book media, and focusing on phonological awareness. The study results show that the teacher's role is significant in optimizing literacy learning for children.Research implications/limitations – This case study focuses on literacy learning in early childhood based on the experiences of two teachers in Bandung, Indonesia.Practical implications –This case study shows that multiple strategies are appropriate to introduce early childhood literacy and prepare children for the next level of education.Originality/value – This study contributes to the understanding of literacy in early childhood. In addition, this study recommends that teachers apply multiple strategies in introducing literacy through play activities.
Paper type Case study
Autism spectrum disorder and physical activity
Authors: Durmuş Kübra , Sarol Halil , Gürkan Rıfat Kerem 
Published: December 2021

Aim: The aim of the study is to examine the relationship between autism spectrum disorder and physical activity in depth. Findings: Autism was first defined by Bleuler, but the history of autism as a term began with the founding of the first pediatric psychiatry clinic by Kanner. Later, autism was defined and revised in the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association (APA) in various periods before currently being expressed by criteria, ratings, and classifications. In 2013, the term autism spectrum disorder (ASD) began to be used. According to data from the Centers for Disease Control and Prevention, ASD is a continuously increasing situation with the incidence of 1 in 54 children according to 2020 data. The increasing incidence and difficulties experienced in many areas by individuals with ASD like deficiencies
​Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Amaç: Araştırmanın amacı, otizm spectrum bozukluğu ve fiziksel aktivite ilişkisini derinlemesine incelemektir. Bulgular: İlk defa Beuler tarafından tanımlanan otizm teriminin; Kanner’in çocuk psikiyatri kliniğini kurması ile birlikte tarihsel süreç içerisinde kullanılmaya başlandığı görülmektedir. Sonraki süreçlerde otizm özellikle Amerikan Psikiyatri Birliği Ruhsal Bozuklukların Tanısal ve İstatistiksel El Kitabında (APA) çeşitli dönemlerde tanımlanmış ve çeşitli revizyonlar yapılarak günümüze gelen kriterleri, dercelendirmeleri, sınıflandırmaları ile ifade edildiği görülmektedir. 2013 yılında otizm spektrum bozukluğu (OSB) olarak kullanılmaya başlanmıştır. Hastalık Kontrol Önleme Merkezi’nin verileri kapsamında OSB, 2020 verilere göre 54 çocukta 1 olarak görülme sıklığı sürekli artan bir durum olarak karşımıza çıkmaktadır. Sıklığının artması ve OSB’li bireylerde yaşanan çeşitli, sözel ya da sözel olmayan iletişim davranışlarında eksiklikler, kalıplaşmış ya da kısıtlayıcı motor hareketler gibi birçok alandaki aksaklıklar bireylerin yaşamlarını olumsuz yönde etkilemekte ve fiziksel aktiviteye katılımlarında ise birer engel olarak karşımıza çıkmaktadır. OSB’li bireylerin her açıdan daha sağlıklı birer birey olmalarında fiziksel aktivitenin önemli bir etkisi bulunmaktadır. Sonuç: Tüm bireyler için katılımı önemli olan fiziksel aktivite, OSB’li bireylerin motor becerilerinden, psikolojik, sosyal ve aile yaşantısına kadar etki eden pek çok alanda önemli katkılar sağlamaktadır. Bu olumlu etkiler özellikle OSB’li bireylerin yaşam kalitesine önemli ölçüde etki etmektedir.
Navigating and resisting the compulsory military service in Iran: embodied experiences of non-heterosexual Iranian men
Authors: Naeimi Mohammad , Kjaran Jón Ingvar 
Published: December 2021

Abstract
In the homosocial space of the all male military service, (hetero)masculinity and gender normativity are promoted and bravery and warrior mentality are highly valued. On this basis, policing gender and sexuality is a relevant issue, aiming to reward heteronormativity and hyper masculinity and marginalize non heterosexuality and gender nonconforming performances. In the Iranian context, since the Iran Iraq war (1980–1988), military service has produced a feature of militarized (hetero)masculinities through the cult of martyrdom. It enforces soldiers to stand up against the enemy, be willing to seek martyrdom and sacrifice themselves in order to protect the Islamic Iranian homeland. It is a symbol of entering adulthood and during that time young men are expected to embody the official ideology which revolves around heteronormativity and strict gender norms. In this context, the focus of this paper is the embodied experiences of those young conscripts who do not embody the (hetero)masculine ideal, because they are either non heterosexual or do not fit into the strict regime of gender. Drawing on ethnographic data, and policy documents, this paper shows how the idea of the (hetero)masculine ideal has been translated into practice through the dispositif of the sarbazi and how some young Iranian non heterosexual men try to resist conscription while others try to find ways to carve out a liminal heterotopic space during their military service.
Theranostics – present and future
Authors: Królicki Leszek , Kunikowska Jolanta 
Published: December 2021

Abstract
Theragnostics in nuclear medicine constitute an essential element of precision medicine. This notion integrates radionuclide diagnostics procedures and radionuclide therapies using appropriate radiopharmaceutics and treatment targeting specific biological pathways or receptors. The term theragnostics should also include another aspect of treatment: not only whether a given radioisotopic drug can be used, but also in what dose it ought to be used. Theragnostic procedures also allow predicting the effects of treatment based on the assessment of specific receptor density or the metabolic profile of neoplastic cells. The future of theragnostics depends not only on the use of new radiopharmaceuticals, but also on new gamma cameras. Modern theragnostics already require unambiguous pharmacokinetic and pharmacodynamic measurements based on absolute values. Only dynamic studies provide such a possibility. The introduction of the dynamic total-body PET-CT will enable this type of measurements characterizing metabolic processes and receptor expression on the basis of Patlak plot.
Investigating the efficacy of Curcuma longa against Desulfovibrio desulfuricans influenced corrosion in low-carbon steel
Authors: Sharma Akansha , Ramachandran Manivannan , Selvam Noyel Victoria 
Published: December 2021

Abstract
The effectiveness of Curcuma longa extract in the control of low-carbon steel corrosion caused by sulfate-reducing bacteria (SRB) in Baar’s medium was investigated. The SRB taken for the study was Desulfovibrio desulfuricans. Specimens in contact with the medium containing SRB exhibited a corrosion rate more than 10 times that of the specimens in contact with the medium without SRB. The weight loss studies showed that the addition of 50 ppm C. longa extracts to the medium containing SRB resulted in an average inhibition efficiency of 91.2% for a four week immersion period. The inhibitor extract altered the reaction rates of both cathodic and anodic reactions which were confirmed from the potentiodynamic polarization (PP) studies. Electrochemical impedance spectroscopy (EIS) studies showed a reduction in the number of sessile bacteria upon inhibitor addition which was confirmed by the microscopy. Severe pitting was observed in the morphological analysis of the specimen in the absence of inhibitor treatment. Apart from adsorption onto the specimen surface to minimize the biocorrosion, the inhibitor extract also served as an anti-film forming and antibacterial agent.