bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electromagnetic response from composite carbon-containing structures with technological inhomogeneities at EHF
Authors: Trofimov E A , Kuleshov G E , Moskalenko V D , Badin A V , Dorozhkin K V 
Published: December 2021

Abstract
The results of studies of the electromagnetic response from composite structures made of a carbon-containing polymer with the inclusion of spherical pores in the bulk of the material and with pyramidal corrugation on the surface of the material are presented. The results of modeling the frequency dependences of the transmission, reflection and absorption coefficients in the EHF range are shown. Samples of composite carbon-containing structures with technological inhomogeneities have been fabricated by 3D printing. Measurements of the electromagnetic response from experimental samples were carried out in the frequency range from 100 to 1000 GHz. At frequencies up to 250 GHz, the inclusion of air pores in the polymer volume reduces the transmission coefficient, practically does not affect the reflection, and increases the absorption. Pyramid corrugated material absorbs more than 99% of radiation in the frequency range from 200 to 635 GHz.
Quantum-mechanical model of dielectric losses in nanometer layers of solid dielectrics with hydrogen bonds at ultra-low temperatures
Authors: Kalytka V A , Mekhtiev A D , Sh Madi P , Bashirov A V 
Published: December 2021

AbstractUpon based the finite difference methods construct the solutions for Liouville quantum kinetic equation linearized by the external field, in complex with the stationary Schrodinger equation and the Poisson operator equation, for an ensemble of non-interacting hydrogen ions (protons) migrating in the field of a crystal lattice perturbed by a variable polarizing field. The influence of the phonon subsystem is not taken into account. The equilibrium (non-balanced) proton density matrix is calculated using quantum Boltzmann statistics. The temperature spectra of dielectric losses tangent angle for hydrogen bonded crystals (HBC) in a wide temperature range (50–550 K) are calculated. At the theoretical level detected the effects of nano-crystalline states (1–10 nm) during the polarization of HBC in the region of ultra-low temperatures (4–25 K).
Realization of actions of characters and combustion process in the system of 3D modeling of the evacuation process
Authors: Tugarinov M A , Shulga I D , Yurchenko E A , Torgaev S N 
Published: December 2021

Abstract
The article presents the results of action modules software implementation in the 3D modeling system of the evacuation process in emergency situations. In particular, the software implementation of such actions of the model characters as organizing a group for evacuation, providing assistance to the victim, taking measures to extinguish the fire is presented. The article also presents the physicochemical properties of materials that are taken into account in model for simulating combustion and smoke formation processes. The software implementation is based on the Unreal Engine program and using automatic descriptions of the physical and psychological states of the characters. The descriptions of the possibility of creating characters in the model with different physical and psychological parameters and collecting statistical data on their condition are given.
GBTX emulator for development and special versions of GBT-based readout chains
Authors: Zabołotny W.M. , Byszuk A.P. , Dementev D. , Emschermann D. , Gumiński M. , Kruszewski M. , Miedzik P. , Poźniak K. , Romaniuk R. , Schmidt C.J. , Shitenkov M. 
Published: December 2021

Abstract
The GBTX ASIC is a standard solution for providing fast control and data readout for radiation detectors used in HEP experiments. However, it is subject to export control restrictions due to the usage of radiation-hard technology. An FPGA-based GBTX emulator (GBTxEMU) has been developed to enable the development of GBT-based readout chains in countries where the original GBTX cannot be imported. Thanks to utilizing a slightly modified GBT-FGPA core, it maintains basic compatibility with standard GBT-based systems. The GBTxEMU also may be an interesting solution for developing GBT-based readout chains for less demanding experiments.
Surface plasmon resonance enhanced transverse magneto-optical Kerr effect and the detection performance of nanopore arrays
Authors: Zhang Weiwei , Yao Haizi , Lu Yao 
Published: December 2021

Abstract
The introduction of a magnetic component to the surface plasmon resonance (SPR) structure to form a magneto-optical surface plasmonic resonance (MOSPR) detector is an effective method for enhancing the detection limit for small molecules at low concentrations. This is important for biosensing, early disease diagnosis, drug discovery, and the detection of contamination in solutions and gases. In this study, an MOSPR crystal composed of a Co6Ag94 slab covered by a subwavelength periodic square array of gold (Au) nanopores was designed to theoretically examine the mechanism by which MOSPR crystals detect glucose concentrations through the transverse magneto-optical Kerr effect (T-MOKE). Owing to the excitation of SPR at the interface between the glucose solution and Au film, a Fano-like sharp T-MOKE spectrum with a narrow linewidth and a high amplitude was obtained, thus producing a high sensitivity of 159° RIU−1 and a high figure of merit of the order of 103 RIU−1. This corresponds to a glucose detection limit of 0.0066 g ml−1, which is more accurate than that previously reported. This design provides an alternative method for detecting analytes’ concentrations in aqueous environments.
Rigorous accounting diffraction on non-plane gratings irradiated by non-planar waves
Authors: Goray Leonid I 
Published: December 2021

Abstract
The modified boundary integral equation method (MIM) is considered a rigorous theoretical application for the diffraction of cylindrical waves by arbitrary profiled plane gratings, as well as for the diffraction of plane/non-planar waves by concave/convex gratings. This study investigates 2D diffraction problems of the filiform source electromagnetic field scattered by a plane lamellar grating and of plane waves scattered by a similar cylindrical-shaped grating. Unlike the problem of plane wave diffraction by a plane grating, the field of a localised source does not satisfy the quasi-periodicity requirement. Fourier transform is used to reduce the solution of the problem of localised source diffraction by the grating in the whole region to the solution of the problem of diffraction inside one Floquet channel. By considering the periodicity of the geometry structure, the problem of Floquet terms for the image can be formulated so that it enables the application of the MIM developed for plane wave diffraction problems. Accounting of the local structure of an incident field enables both the prediction of the corresponding efficiencies and the specification of the bounds within which the approximation of the incident field with plane waves is correct. For 2D diffraction problems of the high-conductive plane grating irradiated by cylindrical waves and the cylindrical high-conductive grating irradiated by plane waves, decompositions in sets of plane waves/sections are investigated. The application of such decomposition, including the dependence on the number of plane waves/sections and radii of the grating and wave front shape, was demonstrated for lamellar, sinusoidal and saw-tooth grating examples in the 0th and −1st orders as well as in the transverse electric and transverse magnetic polarisations. The primary effects of plane wave/section partitions of non-planar wave fronts and curved grating shapes on the exact solutions for 2D and 3D (conical) diffraction problems are discussed.
Investigation of the compact torus plasma motion in the KTX-CTI device based on circuit analyses
Authors: DONG Qilong , KONG Defeng , WU Xiaohe , YE Yang , YANG Kun , LAN Tao , CHEN Chen , WU Jie , ZHANG Sen , MAO Wenzhe , ZHAO Zhihao , MENG Fanwei , ZHANG Xiaohui , HUANG Yanqing , BAI Wei , YANG Dezheng , WEN Fei , ZI Pengfei , LI Lei , HU Guanghai , ZHANG Shoubiao , ZHUANG Ge 
Published: December 2021

Abstract
Compact torus (CT) injection is one of the most promising methods for the central fuelling of next-generation reactor-grade fusion devices due to its high density, high velocity, and self-contained magnetised structure. A newly compact torus injector (CTI) device in Keda Torus eXperiment (KTX), named KTX-CTI, was successfully developed and tested at the University of Science and Technology in China. In this study, first, we briefly introduce the basic principles and structure of KTX-CTI, and then, present an accurate circuit model that relies on nonlinear regression analysis (NRA) for studying the current waveform of the formation region. The current waveform, displacement, and velocity of CT plasma in the acceleration region are calculated using this NRA-based one-dimensional point model. The model results were in good agreement with the experiments. The next-step upgrading reference scheme of the KTX-CTI device is preliminarily investigated using this NRA-based point model. This research can provide insights for the development of experiments and future upgrades of the device.
The fission yeast bromodomain protein Bdf2 is required for the growth of cells with circular chromosomes
Authors: Yasuda Misaki , Habib Ahmed G K , Sugiura Kanako , Shamim Hossain Mohammad , Ueno Masaru 
Published: December 2021

ABSTRACT
Circular chromosomes have frequently been observed in tumors of mesenchymal origin. In the fission yeast Schizosaccharomyces pombe, deletion of pot1+ results in rapid telomere loss, and the resulting survivors have circular chromosomes. Fission yeast has 2 bromodomain and extra-terminal (BET) proteins, Bdf1 and Bdf2; both are required for maintaining acetylated histones. Here, we found that bdf2, but not bdf1, was synthetically lethal with pot1. We also obtained a temperature-sensitive bdf2-ts mutant, which can grow at high temperatures but becomes camptothecin sensitive. This suggests that Bdf2 is defective at high temperatures. The cell cycle of the pot1 bdf2-ts mutant was delayed in the G2 and/or M phase at a semipermissive temperature. Furthermore, a temperature-sensitive mutant of mst1, which encodes histone acetyltransferase, showed a synthetic growth defect with a pot1 disruptant at a semipermissive temperature. Our results suggest that Bdf2 and Mst1 are required for the growth of cells with circular chromosomes.
The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway
Authors: Tsuru Ayano , Hamazaki Yumi , Tomida Shuta , Ali Mohammad Shaokat , Kage-Nakadai Eriko 
Published: December 2021

ABSTRACT
Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.
EGRET: edge aggregated graph attention networks and transfer learning improve protein–protein interaction site prediction
Authors: Mahbub Sazan , Bayzid Md Shamsuzzoha 
Published: December 2021

AbstractMotivationProtein–protein interactions (PPIs) are central to most biological processes. However, reliable identification of PPI sites using conventional experimental methods is slow and expensive. Therefore, great efforts are being put into computational methods to identify PPI sites.ResultsWe present Edge Aggregated GRaph Attention NETwork (EGRET), a highly accurate deep learning-based method for PPI site prediction, where we have used an edge aggregated graph attention network to effectively leverage the structural information. We, for the first time, have used transfer learning in PPI site prediction. Our proposed edge aggregated network, together with transfer learning, has achieved notable improvement over the best alternate methods. Furthermore, we systematically investigated EGRET’s network behavior to provide insights about the causes of its decisions.AvailabilityEGRET is freely available as an open source project at https://github.com/Sazan-Mahbub/EGRET.Contactshams_bayzid@cse.buet.ac.bd
Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights
Authors: Gonzalez Macarena B , Robker Rebecca L , Rose Ryan D 
Published: December 2021

Abstract
The prevalence of obesity in adults worldwide, and specifically in women of reproductive age, is concerning given the risks to fertility posed by the increased risk of type 2 diabetes, metabolic syndrome, and other noncommunicable diseases. Obesity has a multi-systemic impact in female physiology that is characterized by the presence of oxidative stress, lipotoxicity, and the activation of pro-inflammatory pathways, inducing tissue-specific insulin resistance and ultimately conducive to abnormal ovarian function. A higher body mass is linked to Polycystic Ovary Syndrome, dysregulated menstrual cycles, anovulation, and longer time to pregnancy, even in ovulatory women. In the context of assisted reproductive technology (ART), compared to women of normal body mass index, obese women have worse outcomes in every step of their journey, resulting in reduced success measured as live birth rate. Even after pregnancy is achieved, obese women have a higher chance of miscarriage, gestational diabetes, pregnancy complications, birth defects, and most worryingly, a higher risk of stillbirth and neonatal death. The potential for compounding effects of ART on pregnancy complications and infant morbidities in obese women has not been studied. There is still much debate in the field on whether these poorer outcomes are mainly driven by defects in oocyte quality, abnormal embryo development, or an unaccommodating uterine environment, however the clinical evidence to date suggests a combination of all three are responsible. Animal models of maternal obesity shed light on the mechanisms underlying the effects of obesity on the peri-conception environment, with recent findings pointing to lipotoxicity in the ovarian environment as a key driver of defects in oocytes that have not only reduced developmental competence but long-lasting effects in offspring health.
Laparoscopic versus open colectomy for locally advanced T4 colonic cancer: meta-analysis of clinical and oncological outcomes
Authors: Podda Mauro , Pisanu Adolfo , Morello Alessia , Segalini Edoardo , Jayant Kumar , Gallo Gaetano , Sartelli Massimo , Coccolini Federico , Catena Fausto , Di Saverio Salomone 
Published: December 2021

Abstract

Background
The aim of this study was to review the early postoperative and oncological outcomes after laparoscopic colectomy for T4 cancer compared with open surgery.

Method
MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for any relevant clinical study comparing laparoscopic and open colectomy as treatment for T4 colonic cancer. The risk ratio (RR) with 95 per cent c.i. was calculated for dichotomous variables, and the mean difference (m.d.) with 95 per cent confidence interval for continuous variables. Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was implemented for assessing quality of evidence (QoE).

Results
Twenty-four observational studies (21 retrospective and 3 prospective cohort studies) were included, analysing a total of 18 123 patients: 9024 received laparoscopic colectomy and 9099 underwent open surgery. Laparoscopic colectomy was associated with lower rates of mortality (RR 0.48, 95 per cent c.i. 0.41 to 0.56; P &lt; 0.001; I2 = 0 per cent, fixed-effect model; QoE moderate) and complications (RR 0.61, 0.49 to 0.76; P &lt; 0.001; I2 = 20 per cent, random-effects model; QoE very low) compared with an open procedure. No differences in R0 resection rate (RR 1.01, 1.00 to 1.03; P = 0.12; I2 = 37 per cent, random-effects model; QoE very low) and recurrence rate (RR 0.98, 0.84 to 1.14; P = 0.81; I2 = 0 per cent, fixed-effect model; QoE very low) were found.

Conclusion
Laparoscopic colectomy for T4 colonic cancer is safe, and is associated with better clinical outcomes than open surgery and similar oncological outcomes.
Characteristics, surgical outcomes, and influential factors of epilepsy in Sturge-Weber syndrome
Authors: Wang Shu , Pan Junhong , Zhao Meng , Wang Xiongfei , Zhang Chunsheng , Li Tianfu , Wang Mengyang , Wang Jing , Zhou Jian , Liu Changqing , Sun Yongxing , Zhu Mingwang , Qi Xueling , Luan Guoming , Guan Yuguang 
Published: December 2021

AbstractFew studies have reported the clinical presentation, surgical treatment, outcomes and influential factors for patients with epilepsy and Sturge-Weber syndrome.This large-scale retrospective study continuously enrolled 132 patients with Sturge-Weber syndrome and epilepsy from January 2008 to December 2018 at our hospital to analyse their characteristics. Among these patients, 90 underwent epilepsy surgery, and their postoperative 2-year follow-up seizure, cognitive and motor functional outcomes were assessed and analysed. Univariable and multivariable logistic analyses were conducted to explore the influential factors.Among the patients with Sturge-Weber syndrome for whom characteristics were analysed (n = 132), 76.52% of patients had their first epileptic seizures within their first year of life. The risk factors for cognitive decline were seizure history ≥ 2 years [adjusted odds ratio (aOR) = 3.829, 95% confidence interval (CI): 1.810–9.021, P = 0.008)], bilateral leptomeningeal angiomas (aOR = 3.173, 95% CI: 1.970–48.194, P = 0.013), age at onset &lt;1 year (aOR = 2.903, 95% CI: 1.230–6.514, P = 0.013), brain calcification (aOR = 2.375, 95% CI: 1.396–5.201, P = 0.021) and left leptomeningeal angiomas (aOR = 2.228, 95% CI: 1.351–32.571, P = 0.030). Of the patients who underwent epilepsy surgery (n = 90), 44 were subject to focal resection, and 46 underwent hemisphere surgery (19 anatomical hemispherectomies and 27 modified hemispherotomies). A postoperative seizure-free status, favourable cognitive outcomes, and favourable motor outcomes were achieved in 83.33%, 44.44% and 43.33% of surgical patients, respectively. The modified hemispherotomy group had similar surgical outcomes, less intraoperative blood loss and shorter postoperative hospital stays than the anatomical hemispherectomy group. Regarding seizure outcomes, full resection (aOR = 11.115, 95% CI: 1.260–98.067, P = 0.020) and age at surgery &lt; 2 years (aOR = 6.040, 95% CI: 1.444–73.367, P = 0.031) were positive influential factors for focal resection. Age at surgery &lt; 2 years (aOR = 15.053, 95% CI: 1.050–215.899, P = 0.036) and infrequent seizures (aOR = 8.426, 95% CI: 1.086–87.442, P = 0.042; monthly versus weekly) were positive influential factors for hemisphere surgery.In conclusion, epilepsy surgery resulted in a good postoperative seizure-free rate and favourable cognitive and motor functional outcomes and showed acceptable safety for patients with epilepsy and Sturge-Weber syndrome. Modified hemispherotomy is a less invasive and safer type of hemisphere surgery than traditional anatomic hemispherectomy with similar surgical outcomes. Early surgery may be helpful to achieve better seizure outcomes and cognitive protection, while the risk of surgery for young children should also be considered.
Investigating the impact of early literacy training on white matter structure in prereaders at risk for dyslexia
Authors: Economou Maria , Van Herck Shauni , Vanden Bempt Femke , Glatz Toivo , Wouters Jan , Ghesquière Pol , Vanderauwera Jolijn , Vandermosten Maaike 
Published: December 2021

Abstract
Recent prereading evidence demonstrates that white matter alterations are associated with dyslexia even before the onset of reading instruction. At the same time, remediation of reading difficulties is suggested to be most effective when provided as early as kindergarten, yet evidence is currently lacking on the early neuroanatomical changes associated with such preventive interventions. To address this open question, we investigated white matter changes following early literacy intervention in Dutch-speaking prereaders (aged 5–6 years) with an increased cognitive risk for developing dyslexia. Diffusion-weighted images were acquired before and after a 12-week digital intervention in three groups: (i) at-risk children receiving phonics-based training (n = 31); (ii) at-risk children engaging with active control training (n = 25); and (iii) typically developing children (n = 27) receiving no intervention. Following automated quantification of white matter tracts relevant for reading, we first examined baseline differences between at-risk and typically developing children, revealing bilateral dorsal and ventral differences. Longitudinal analyses showed that white matter properties changed within the course of the training; however, the absence of intervention-specific results suggests that these changes rather reflect developmental effects. This study contributes important first insights on the neurocognitive mechanisms of intervention that precedes formal reading onset.
miRNA-126a-3p participates in hippocampal memory via alzheimer’s disease-related proteins
Authors: Xue Bao , Qu Yu , Zhang Xia , Xu Xu-Feng 
Published: December 2021

AbstractMemory formation and consolidation necessitate gene expression and new protein synthesis. MicroRNAs (miRNAs), a family of small noncoding RNAs that inhibit target gene mRNA expression, are involved in new memory formation. In this study, elevated miR-126a-3p (miR-126) levels were found to contribute to the consolidation of contextual fear memory. Using different commonly mined algorithms and luciferase reporter assay, we found two Alzheimer’s disease (AD)-related proteins, namely EFHD2 and BACE1, but not ADAM9, were the targets downregulated by miR-126 after CFC training. Moreover, we indicated that upregulated miR-126 could promote the formation of contextual fear memory by modulating its target EFHD2. Finally, we demonstrated that miR-126 overexpression in dentate gyrus of hippocampus could reduce Aβ plaque area and neuroinflammation, as well as rescue the hippocampal memory deficits in APP/PS1 mice. This study adds to the growing body of evidence for the role of miRNAs in memory formation and demonstrates the implication of EFHD2 protein regulated by miR-126 in the adult brain.