bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural modeling of lean supply chain enablers: a hybrid AHP and ISM-MICMAC based approach
Authors: Sharma Hemant , Sohani Nagendra , Yadav Ashish 
Published: October 2021

Purpose
Today the role of industry 4.0 plays a very important role in enhancing any supply chain network, as the industry 4.0 supply chain uses Big Data and advanced analytics to inform the complete visibility. Latest data are available to bring clarity and support real-time decision-making in the entire supply chain that’s why adopting optimization techniques such as lean manufacturing and lean supply chain concept for enhancing the supply chain network of the organizations is a good idea and would benefit them in increasing their cost efficiency and productivity. The purpose of this work is to develop a technique, which may be useful for future researchers and managers to identify and classification of the significant lean supply chain enablers.

Design/methodology/approach
In this paper, the authors considered hybrid analytical hierarchy process to find the ranking of the identified lean supply chain enablers by calculating their weightage. Interpretive structural modeling (ISM) is applied to develop the structural interrelationship among various lean supply chain management enablers. Considering the results obtained from ISM the Matrices d'Impacts Croises Multiplication Appliqué a un Classement (MICMAC) analysis is done to identify the driving and dependence power of Lean Supply Chain Management Enablers (LSCMEs).

Findings
Further, the best results applying these methodologies could be used to analyze their inter-relationships for successful Lean supply chain management implementation in an organization. The authors developed an integrated model after the identification of 20 key LSCMEs, which is very helpful to identify and classify the important enablers by ISM methodology and explore the direct and indirect effects of each enabler by MICMAC analysis on the LSCM implementation. This will help organizations optimize their supply chain by selective control of lean enablers.

Practical implications
For lean manufacturing practitioners, the result of the study can be beneficial where the manufacturer is required to increase efficiency and reduce cost and wastage of resources in the lean manufacturing process, as well as in enhancing the supply chain.

Originality/value
This paper is the first research paper that considered firstly deep literature review of identified lean supply chain enablers and second developed structured modeling of various lean enablers of supply chain with the help of various methodologies.
User design as a double-edged sword: exploring perceived self-improvement and uncertainty in purchasing utilitarian products
Authors: Chen Chunfeng , Zhang Depeng , Lu Kevin , Wang Catherine L. 
Published: October 2021

Purpose
This paper aims to examine the effects of design sources (user design vs. company design) on customers’ perceived value (perceived self-improvement and perceived uncertainty) and consequently purchase intention, as well as the moderating effect of brand strength in the context of purchasing utilitarian products.

Design/methodology/approach
Two studies were conducted. Study 1 used a laboratory experiment (n = 160) to test the effects of design sources on perceived self-improvement, perceived uncertainty and purchase intention. Study 2 used an online experiment (n = 312) to examine the moderating effect of brand strength.

Findings
The results showed that user design is a double-edged sword for companies. Compared with company design, user design is associated with stronger self-improvement and uncertainty as perceived by customers. Perceived self-improvement is positively related to purchase intention, while perceived uncertainty undermines purchase intention. Moreover, for weak brands, perceived self-improvement is significantly stronger in user design than company design, while for strong brands, this relationship is not significant.

Originality/value
This paper draws on mental accounting theory to study the perceived benefits and risks of user design of utilitarian products, and highlights the double-edged effects of user design on customers’ perceived value and purchase decision. The findings provide more rounded insights on user design of utilitarian products, complementing the one-sided view of customers’ positive perceives of user design in unclassified product categories.
Integrating research tools with library websites
Authors: De Sarkar Tanmay 
Published: October 2021

Purpose
The present investigation aims to measure the extent of the adoption of research tools among libraries of higher education (HE) institutes across the world based on the types of research tools and their diverse purposes of use. This study also intends to identify the current practices followed by the HE libraries to implement research tools.

Design/methodology/approach
First, a stratified sampling method was used to select 130 HE libraries from four continents – Asia, Oceania, Europe and North America. Second, a two-step Web content analysis was followed to collect data from the selected libraries along the parameters chosen for the survey.

Findings
This study gives an overview of the recent advances in the use of research tools by the libraries with numerous examples. Highlighting the differential rate of adoption of research tools across the regions, this study illustrates the degree of acceptance of research tools among the libraries.

Research limitations/implications
This study limits itself to a handful of libraries with English websites in four regions only to avoid the language limitation of the researcher. Inaccessible websites of libraries of HE institutes were also excluded from the survey.

Originality/value
Future researchers may use the evaluation instruments as basic tools to develop advanced research instruments to carry out Web content analysis in diverse spheres. This study guides librarians to develop an improved understanding of the requirements of an immersive online environment with enhanced accessibility to a multiplicity of research tools and facilities to provide improved research support throughout the entire research life cycle.
Ambidextrous learning in a customer order–based context
Authors: Engström Annika , Käkelä Nikolas , Wikner Joakim 
Published: October 2021

Purpose
The purpose of the paper is to describe ambidextrous learning in organizations within the customer order-based context (COBC), here based on a dynamic view of work processes. The study focuses on how organizations can learn while working with customer orders, considering learning in organizations as both a process and an outcome.

Design/methodology/approach
This conceptual article focuses on learning in the COBC, where the individual customer requirements represent a key input into the organization’s work processes, thus limiting the possibilities to plan and standardize. The COBC brings about challenges and potentials for learning in organizations where task variety and complexity are high and in which the contradictory interplay between efficiency and responsiveness is apparent not only at a strategic level but also at an operative level in the customer order fulfillment processes. Depending on the variations in tasks and parallel complex work processes between different units in the organization, the ambidextrous learning dynamic can appear in the COBC.

Findings
Five propositions were made from the analysis: Proposition 1: Learning in the COBC can occur both in real-time but also in retrospect and with sporadic and recurrent interventions. Proposition 2: Learning in the COBC can occur for, as well as from, customer order processes. Proposition 3: Learning in the COBC varies and will depend on the delivery strategy. Proposition 4: Learning can be stimulated by the variation in priorities among customer orders in the COBC because the work characteristics for the back office and front office differ between customer order fulfillment processes. Proposition 5: Learning in the COBC can occur both within the back office and front office but also between these organizational units. The paper discusses the importance of building learning infrastructure in COBC and how that can be supported by a suggested learning office.

Originality/value
The present study demonstrates the importance of functions being able to act both as back office and front office in relation to delivery strategy. It also shows the ambidextrous learning process for the sake of improving both the internal efficiency and external effectiveness across the organization.
Quantification of marine benthic communities with metabarcoding
Authors: Klunder Lise , van Bleijswijk Judith D. L. , Kleine Schaars Loran , van der Veer Henk W. , Luttikhuizen Pieternella C. , Bijleveld Allert I. 
Published: October 2021

AbstractDNA metabarcoding methods have been implemented in studies aimed at detecting and quantifying marine benthic biodiversity. In such surveys, universal barcodes are amplified and sequenced from environmental DNA. To quantify biodiversity with DNA metabarcoding, a relation between the number of DNA sequences of a species and its biomass and/or the abundance is required. However, this relationship is complicated by many factors, and it is often unknown. In this study, we validate estimates of biomass and abundance from molecular approaches with those from the traditional morphological approach. Abundance and biomass were quantified from 126 samples of benthic intertidal mudflat using traditional morphological approaches and compared with frequency of occurrence and relative read abundance estimates from a molecular approach. A relationship between biomass and relative read abundance was found for two widely dispersed annelid taxa (Pygospio and Scoloplos). None of the other taxons, however, showed such a relationship. We discuss how quantification of abundance and biomass using molecular approaches are hampered by the ecology of DNA i.e. all the processes that determine the amount of DNA in the environment, including the ecology of the benthic species as well as the compositional nature of sequencing data.
Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age
Authors: Maybury‐Lewis Sun Y. , Brown Abigail K. , Yeary Mitchell , Sloutskin Anna , Dhakal Shleshma , Juven‐Gershon Tamar , Webb Ashley E. 
Published: October 2021

AbstractNeural stem cells (NSCs) in the adult and aged brain are largely quiescent, and require transcriptional reprogramming to re‐enter the cell cycle. However, the mechanisms underlying these changes and how they are altered with age remain undefined. Here, we identify the chromatin accessibility differences between primary neural stem/progenitor cells in quiescent and activated states. These distinct cellular states exhibit shared and unique chromatin profiles, both associated with gene regulation. Accessible chromatin states specific to activation or quiescence are active enhancers bound by key pro‐neurogenic and quiescence factors. In contrast, shared sites are enriched for core promoter elements associated with translation and metabolism. Unexpectedly, through integrated analysis, we find that many sites that become accessible during NSC activation are linked to gene repression and associated with pro‐quiescence factors, revealing a novel mechanism that may preserve quiescence re‐entry. Furthermore, we report that in aged NSCs, chromatin regions associated with metabolic and transcriptional functions bound by key pro‐quiescence transcription factors lose accessibility, suggesting a novel mechanism of age‐associated NSC dysfunction. Together, our findings reveal how accessible chromatin states regulate the transcriptional switch between NSC quiescence and activation, and how this switch is affected with age.
Monomeric C‐reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype‐dependent pattern: A risk factor for Alzheimer’s disease?
Authors: Zhang Zhengrong , Na Hana , Gan Qini , Tao Qiushan , Alekseyev Yuriy , Hu Junming , Yan Zili , Yang Jack B. , Tian Hua , Zhu Shenyu , Li Qiang , Rajab Ibraheem M. , Blusztajn Jan Krizysztof , Wolozin Benjamin , Emili Andrew , Zhang Xiaoling , Stein Thor , Potempa Lawrence A. , Qiu Wei Qiao 
Published: October 2021

AbstractIn chronic peripheral inflammation, endothelia in brain capillary beds could play a role for the apolipoprotein E4 (ApoE4)‐mediated risk for Alzheimer's disease (AD) risk. Using human brain tissues, here we demonstrate that the interactions of endothelial CD31 with monomeric C‐reactive protein (mCRP) versus ApoE were linked with shortened neurovasculature for AD pathology and cognition. Using ApoE knock‐in mice, we discovered that intraperitoneal injection of mCRP, via binding to CD31 on endothelial surface and increased CD31 phosphorylation (pCD31), leading to cerebrovascular damage and the extravasation of T lymphocytes into the ApoE4 brain. While mCRP was bound to endothelial CD31 in a dose‐ and time‐dependent manner, knockdown of CD31 significantly decreased mCRP binding and altered the expressions of vascular‐inflammatory factors including vWF, NF‐κB and p‐eNOS. RNAseq revealed endothelial pathways related to oxidative phosphorylation and AD pathogenesis were enhanced, but endothelial pathways involving in epigenetics and vasculogenesis were inhibited in ApoE4. This is the first report providing some evidence on the ApoE4‐mCRP‐CD31 pathway for the cross talk between peripheral inflammation and cerebrovasculature leading to AD risk.
What does it take to start a business? Constraint appraisal as predictor of taking entrepreneurial action among nascent entrepreneurs
Authors: López Aníbal , Neves Pedro , González‐Morales M. Gloria 
Published: October 2021

AbstractCombining the transactional ideas of cognitive appraisals and the affective events theory, we explore the subjective nature of entrepreneurial constraints and its consequences for nascent entrepreneurial action. In Study 1, we developed a measure of entrepreneurial constraint appraisal (opportunity and threat). In Study 2, using a cross‐lagged panel design, we found that entrepreneurial passion mediates the positive relationship between opportunity appraisal and taking action. In Study 3, findings provided support for the long‐term effects of this relationship (3 and 9 months after). Our study provides empirical evidence on how constraints evaluated as opportunities ignite entrepreneurial passion and lead to nascent entrepreneurship activity.
Everyday activisms: Parental places and emotions of disability activism in Wellington, Aotearoa New Zealand
Authors: Morrison Carey‐Ann , Woodbury Esther , Johnston Lynda , Longhurst Robyn 
Published: October 2021

AbstractThis paper considers the everyday spaces and places of disability activism for parents of disabled children in Wellington, Aotearoa New Zealand. Geographers and disability scholars are yet to consider disability activism in a range of everyday child–parent spaces. Parents resist, rework, and subvert ableist structures and spaces in ways that may seem unremarkable, but that are indeed significant acts. We question the meaning of activism by examining the relationship between “activism” and “everyday family lives.” Sara Ahmed's concept of “affinity of hammers” is adopted to understand how parental disability activism is enacted in health, educational, and disability spaces and places. Interviews and written responses from seven parents (five mothers and two fathers) of disabled children are analysed. Findings are divided into three themes: first, quiet, implicit forms of activism; second, fighting for rights and equitable access; and third, using personal experience to educate people about disability rights. We conclude that family disability activism – in its myriad forms – can provide leadership to other people, challenge ableism, and help geographers and others to rethink common understandings of activism.
Repeat MRI during active surveillance: natural history of prostatic lesions and upgrading rates
Authors: Luzzago Stefano , Piccinelli Mattia Luca , Mistretta Francesco A. , Bianchi Roberto , Cozzi Gabriele , Di Trapani Ettore , Cioffi Antonio , Catellani Michele , Fontana Matteo , Jannello Letizia Maria Ippolita , Botticelli Francesco Maria Gerardo , Marvaso Giulia , Alessi Sarah , Pricolo Paola , Ferro Matteo , Matei Deliu‐Victor , Jereczek‐Fossa Barbara A. , Fusco Nicola , Petralia Giuseppe , de Cobelli Ottavio , Musi Gennaro 
Published: October 2021

ObjectivesTo assess upgrading rates in patients on active surveillance (AS) for prostate cancer (PCa) after serial multiparametric magnetic resonance imaging (mpMRI).MethodsWe conducted a retrospective analysis of 558 patients. Five different criteria for mpMRI progression were used: 1) a Prostate Imaging Reporting and Data System (PI‐RADS) score increase; 2) a lesion size increase; 3) an extraprostatic extension score increase; 4) overall mpMRI progression; and 5) the number of criteria met for mpMRI progression (0 vs 1 vs 2–3). In addition, two definitions of PCa upgrading were evaluated: 1) International Society of Urological Pathology Grade Group (ISUP GG) ≥2 with >10% of pattern 4 and 2) ISUP GG ≥ 3. Estimated annual percent changes methodology was used to show the temporal trends of mpMRI progression criteria. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of mpMRI progression criteria were also analysed. Multivariable logistic regression models tested PCa upgrading rates.ResultsLower rates over time for all mpMRI progression criteria were observed. The NPV of serial mpMRI scans ranged from 90.5% to 93.5% (ISUP GG≥2 with >10% of pattern 4 PCa upgrading) and from 98% to 99% (ISUP GG≥3 PCa upgrading), depending on the criteria used for mpMRI progression. A prostate‐specific antigen density (PSAD) threshold of 0.15 ng/mL/mL was used to substratify those patients who would be able to skip a prostate biopsy. In multivariable logistic regression models assessing PCa upgrading rates, all five mpMRI progression criteria achieved independent predictor status.ConclusionDuring AS, approximately 27% of patients experience mpMRI progression at first repeat MRI. However, the rates of mpMRI progression decrease over time at subsequent mpMRI scans. Patients with stable mpMRI findings and with PSAD < 0.15 ng/mL/mL could safely skip surveillance biopsies. Conversely, patients who experience mpMRI progression should undergo a prostate biopsy.
Review: Ecological awareness, anxiety, and actions among youth and their parents – a qualitative study of newspaper narratives
Authors: Benoit Laelia , Thomas Isaiah , Martin Andrés 
Published: October 2021

BackgroundDespite the growing impact of climate change on mental health, there have been few studies to date investigating how children and teenagers manage their ecological grief and eco‐anxiety and how they can leverage it into environmental action. In this scoping review, we analyze lay press narratives about how youth respond to climate change to examine the dynamics between minors and adults around the evolving climate crisis.MethodsWe included articles published between 2018 and 2021 in six of the top ten American newspapers by circulation about young people during the climate crisis. The 131 articles we selected addressed the attitudes of children, adolescents, and parents toward the climate crisis. We conducted a qualitative analysis based on discourse analysis aided by NVivo software.ResultsNewspaper articles commonly categorized children, adolescents, and their respective perspectives and experiences around climate change along four patterns of discourse: (a) fierce young activists; (b) adultified children; (c) innocent victims; and/or (d) ultimate saviors. In turn, articles considered parents and adults in one of four paradigmatic ways: (a) experiencing eco‐anxiety through parenthood; (b) taming children’s eco‐anxiety; (c) criticizing youth‐led activism; and/or (d) reimagining climate action as a source of meaning in the lives of young people.ConclusionThrough the framework of childism, or prejudice against children, we conceptualize immature ways for adults to respond to youths’ concerns as a defensive stance against overwhelming climate change anxiety. Alternatively, principles of existential psychology can help inform healthier and more productive responses from parents, clinicians, educators, and public health officials as they seek truthful yet supportive responses to address legitimate ecological threats that will disproportionately affect generations to come.
Hippocampal subregional alterations and verbal fluency in the early stage of type 2 diabetes mellitus
Authors: Lee Suji , Kim Tammy D. , Kim Rye Young , Joo Yoonji , Chung Yong‐An , Lim Soo Mee , Lyoo In Kyoon , Kim Jungyoon , Yoon Sujung 
Published: October 2021

AbstractGrowing evidence indicates that type 2 diabetes mellitus (T2DM)‐related cognitive dysfunction may develop in the early stage of the disease and is often accompanied by hippocampal structural alterations. In the current study, we investigated volume and shape alterations of the hippocampus at a subregional level in patients with T2DM. With the use of high‐resolution brain structural images that were obtained from 30 T2DM patients with less than 5 years of disease duration and 30 healthy individuals, volumetric and shape analyses were performed. We also assessed the relationship between T2DM‐related hippocampal structural alterations and performance on verbal fluency. In volumetric analysis, total hippocampal volume was smaller in the T2DM group, relative to the control group. At a subregional level, T2DM patients showed significant inward deformation and volume reduction of the right dentate gyrus and cornu ammonis 2/3 subregions as compared with healthy individuals. In particular, T2DM patients with lower performance on verbal fluency had smaller right dentate gyrus volumes relative to those with higher performance. These findings suggest that the hippocampus may undergo atrophy at a subregional level even in the early stage of T2DM, and this subregion‐specific atrophy may be associated with reduced performance on verbal fluency.