bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plantas Fungicidas Utilizadas em Comunidades Rurais da Região Sul do Piauí, Nordeste do Brasil
Authors: Sousa Santina Barbosa de , Barros Roseli Farias Melo de , Andrade Laíse de Holanda Cavalcanti , Lopes João Batista 
Published: December 2021

Mediante estudo etnobotânico, objetivou-se listar plantas utilizadas para tratamento de infecções fúngicas em comunidades rurais do Nordeste do Brasil. Utilizou-se formulários semiestruturados, envolvendo 176 pessoas (99 do gênero feminino e 77 do masculino). Realizou-se turnês-guiadas para coletas e as exsicatas foram incorporadas ao Herbário Graziela Barroso (TEPB), da Universidade Federal do Piauí. Analisou-se os dados no NTSYSpc v.2.10t. Obteve-se 175 citações, identificando 36 espécies, distribuídas em 24 famílias e 35 gêneros. 84% são indicadas para tratamento de micoses em humanos, 10% em animais e 6% para fitopatógenos. Das plantas citadas, 54% são nativas, sendo a folha a parte mais usada (54%). As preparações foram cataplasma (55%), in natura (36%), decocção (5%) e a maceração (3%). Verificou-se que há diferença de conhecimento do número de espécies entre as comunidades, sendo Tamboril e Capim as mais similares. O saber popular sobre plantas fungicidas tem potencial interesse para a medicina humana e veterinária.
DIAGNÓSTICO SITUACIONAL DOS PACIENTES DO COMPONENTE ESPECIALIZADO DE ASSISTÊNCIA FARMACÊUTICA DO PIAUÍ E ORIENTAÇÃO FARMACÊUTICA PARA USO RACIONAL DE MEDICAMENTOS
Authors: De Sousa Araújo Camila , De Oliveira Nery Neto José Arimatéia , Machado de Sousa Patrícia Caroline , Dos Santos Soares Joslanne , Portela Carneiro Sabrina Maria , Rocha e Silva Hilris 
Published: December 2021

A Assistência Farmacêutica refere-se a um conjunto de orientações que devem garantir acesso aos medicamentos e sua utilização adequada. Nesse sentido, o presente artigo consiste na apresentação e discussão dos dados provenientes de um projeto que objetivou diagnosticar as condições clínicas de maior incidência em usuários do Componente Especializado de Assistência Farmacêutica do Piauí, de modo a propor direcionamentos que favoreçam ações de intervenção e orientação farmacêutica. O projeto contou com a colaboração de alunos extensionistas do curso de farmácia da Universidade Federal do Piauí, executando a proposta em quatro etapas: diagnóstico situacional, elaboração de material educativo, orientação farmacêutica e, por fim, campanhas de conscientização. Um bom índice de avaliação da aceitabilidade da população foi atingido, comprovando a relevância de projetos como esse.
Palavras-chave: Educação em farmácia; Cuidados farmacêuticos; Uso de medicamentos
PROJETO PENSAR:
Authors: Ferreira Targino da Cruz Melo Jacicleide , De Fátima Barbosa da Silva Cantalice Gizolene , Mariz de Oliveira Isabela 
Published: December 2021

RESUMO

O presente texto tem como objetivo socializar resultados decorrentes de um projeto de extensão desenvolvido no ano de 2020, tendo como estratégia metodológica a realização de experiências de pensamento na perspectiva da Filosofia com Crianças. A ação atendeu alunos (crianças do Ensino Fundamental) de escolas da rede municipal de Caicó/RN. A equipe organizadora foi constituída por um professor da rede básica de ensino e cinco voluntários estudantes do curso de Pedagogia (CERES/UFRN). Foram realizadas oficinas com as crianças, cujos resultados apontaram a potencialidade da metodologia da Filosofia com criança para o desenvolvimento de habilidades de investigação, raciocínio, organização da informação e de tradução (diálogo) no processo de ensino e aprendizagem com crianças.

Palavras-chave: Pensar; Filosofia com Crianças; Linguagem; Extensão Universitária.
PROMOÇÃO DE INFORMAÇÃO A TRABALHADORES PARA O ENFRENTAMENTO DA COVID-19:
Authors: Alexandre André , Valverde Marques dos Santos Sérgio , Pimenta de Vasconcelos Neto Jony , Dos Reis Neiva Ana Flávia , Gonçalves da Silva Policardo 
Published: December 2021

Com a pandemia do novo coronavírus muitas ações foram adotadas para combater sua disseminação, como o isolamento social. No entanto, muitos trabalhadores, considerados essenciais, continuaram nos seus postos de trabalhos, como supermercados, açougues, padarias, postos de combustíveis, farmácias, entre outros. Esses trabalhadores estão expostos ao risco de contaminação, uma vez que, a comunicação e a orientação sobre as formas de contágio ainda são limitadas. Neste sentido, relata-se aqui a experiência sobre um projeto de extensão que visou suprir a necessidade da promoção de informações e proteger tais trabalhadores em Passos-MG, oferecendo-lhes máscaras e fôlderes informativos, além de lives, enquadrando-se numa abordagem de saúde pública que se atentou para a saúde física e mental dos trabalhadores. Por fim, conclui-se que o projeto teve êxito em seus objetivos.

Palavras chave: COVID-19; Saúde do Trabalhador; Extensão Comunitária; Prevenção de Doenças
MULHER EM EVIDÊNCIA: TRADUÇÃO DO CONHECIMENTO CIENTÍFICO PARA MULHERES POR MEIO DE UMA REDE SOCIAL
Authors: Duarte Marinho Maria de Fátima , Nunes Ana Beatriz da Fonseca , Pereira Katia Maria , Pereira Ayrlla Vytória , Lira Jayara Mikarla de , Magalhães Adriana Gomes , Correia Grasiéla Nascimento 
Published: December 2021

Durante a pandemia do novo coronavírus (SARS-CoV-2), as mulheres apresentaram dificuldade de acesso à saúde mediante ao risco de transmissão do vírus. Devido a essa necessidade, foi criado o projeto de extensão “Mulher em Evidência – Conhecimento além dos muros do Trairi" que usou o Instagram para disponibilizar conteúdos relacionados à Saúde da Mulher, com embasamento cientifico e linguagem acessível. Foram publicados 72 conteúdos, alcançando 27.325 pessoas e o tema mais curtido foi “O tabu da estética íntima” com 236 curtidas. Inicialmente os extensionistas relataram dificuldade para traduzir o conhecimento científico, entretanto este projeto de extensão alcançou o objetivo de disseminar ciência de qualidade e promover saúde para mulheres.
Palavras-chave: Saúde da Mulher; Infecções por Coronavírus; Rede Social.
Programa Hiperdia em tempos de pandemia pela Covid-19
Authors: Dos Santos de Souza Thais , Sales da Cruz Jamille , Carla Cerqueira dos Santos Vivian , Rodrigues Carvalho Ramona , Mary Andrade Teles Monteiro Nayara 
Published: December 2021

Introdução: Com o advento da pandemia diversos impactos no processo de pensar, fazer e promover saúde. Neste cenário, diversos programas de assistência instituído na Atenção Básica (AB) tiveram suas atividades suspensas, dentre eles o HiperDia, rompendo assim, a integridade e longitudinalidade do processo do cuidar. Diante disso, há uma necessidade de retorno das atividades de modo integral, multidisciplinar e progressivo. Objetivo: Apresentar as vivências, percepções e inferências da equipe de residentes durante o processo de reintegração do programa HiperDia durante à Pandemia Covid-19. Metodologia: A presente obra trata-se de um estudo do tipo relato de experiência, de teor descritivo e abordagem qualitativa sobre uma atividade intervencionista de tempo indeterminado realizado por uma equipe multidisciplinar no município de Itabuna/BA. Resultado e discussão: Com o retorno das atividades, sensibilização da equipe e busca ativa dos usuários foi possível promover atividades de cunho assistencial, de promoção à saúde e prevenção de agravos. Neste contexto, duas atividades intervencionistas foram implementastes, sendo elas: O Mutirão do HiperDia e o Grupo Multiprofissional. No decorrer destas consultas e acompanhamentos foi possível identificar e mitigar multiprofissionalmente fatores estressantes que culminavam no aumento dos valores pressóricos e glicêmicos. Além da ratificação do vínculo e fidelização deste para com a equipe Conclusão: Diante disso, conclui-se a imperatividade do retorno progressivo, integral, multidisciplinar da assistência, bem como, a necessidade da inserção de atividades de educação e saúde e ações intraterritórios visando a melhora da qualidade de vida biopsicossocial.
Hydrogels for Modified-release Drug Delivery Systems
Authors: Zielińska Aleksandra , Eder Piotr , Rannier Lucas , Cardoso Juliana C. , Severino Patrícia , Silva Amélia M. , Souto Eliana B. 
Published: December 2021

Abstract:
Hydrogels for the modified-release drug delivery systems are a continuously growing area of interest
for the pharmaceutical industry. According to the global market, the profit resulting from the use of polymers in
this area is projected to reach $31.4 million by 2027. This review discusses the recent advances in and perspectives
of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic delivery. The
search was conducted, in January 2021, in an extensive database to identify studies published from January
2010 to December 2020. We described the main characteristic of the polymers to obtain an ideal hydrogel for a
specific route of administration and the formulations. It was concluded that the hydrogels are useful to decrease
the number of doses and side effects, promote adhesion of patient, and enhance the bioavailability of the drugs,
thus improving the safety and efficacy of the treatment.
Recent Advances of Nanotechnology in the Diagnosis and Therapy of Triple-
Negative Breast Cancer (TNBC)
Authors: Kanugo Abhishek , Gautam Rupesh K. , Kamal Mohammad Amjad 
Published: December 2021

Background:
The development of advanced treatment of triple-negative breast cancer (TNBC) is the utmost need of an era. TNBC is recognized as the most aggressive, metastatic cancer and the leading cause of mortality in females worldwide. The lack of expression of triple receptors namely, estrogen, progesterone, and human epidermal receptor 2 defined TNBC.

Objective:
The current review introduced the novel biomarkers such as miRNA and family, PD1, EGFR, VEGF, TILs, P53, AR and PI3K, etc. contributed significantly to the prognosis and diagnosis of TNBC. Once diagnosed, the advanced utilization approaches are available for TNBC because of the limitations of chemotherapy. Novel approaches include lipid-based (liposomes, SLN, NLC, and SNEDDS), polymer-based (micelle, nanoparticles, dendrimers, and quantum dots), advanced nanocarriers such as (exosomes, antibody and peptide-drug conjugates), and carbon-based nanocarriers (Carbon nanotubes, and graphene oxide). Lipid-based delivery is used for excellent carriers for hydrophobic drugs, biocompatibility, and lesser systemic toxicities than chemotherapeutic agents. Polymer-based approaches are preferred over lipids for providing longer circulation time, nanosize, high loading efficiency, high linking, avoiding the expulsion of drugs, targeted action, diagnostic and biosensing abilities. Advanced approaches like exosomes, conjugated moieties are preferred over polymeric for possessing potency, high penetrability, biomarkers, and avoiding the toxicity of tissues. Carbon-based gained wide applicability for their unique properties like a versatile carrier, prognostic, diagnostic, sensing, photodynamic, and photothermal characteristics.

Conclusion:
The survival rate can be increased by utilizing several kinds of biomarkers. The advanced approaches can also be significantly useful in the prognosis and theranostic of triple-negative breast cancer. One of the biggest successes in treating with nanotechnology-based approaches is the marked reduction of systemic toxicity with high therapeutic effectiveness compared with chemotherapy, surgery, etc. The requirements such as prompt diagnosis, longer circulation time, high efficiency, and high potency can be fulfilled with these nanocarriers.
Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives
Authors: Farghaly Thoraya A. , Dawood Kamal M. 
Published: December 2021

Abstract:
Despite several reports and reviews addressing the biological significance of pyrazoles
and oxazines, no comprehensive work on the pyrazolo oxazine fused ring system has been published
so far. We report all biological evaluations on pyrazolo-oxazine derivatives in this mini-review to
provide an avenue for medicinal and pharmacological researchers to conduct further in-depth exploration.
Synthesis, Application, and Antibacterial Activity of New Direct Dyes based
on Chromene Derivatives
Authors: Mohamed Fatma A. , Ibrahim Hassan M. , Sheier Mahmoud B. , Reda Maysa M. 
Published: December 2021

Aim:
This study aimed at synthesizing, analyzing, and utilizing two new direct dyes based on chromene derivatives as the chromophoric moiety in dyeing wool, silk, and cotton, with good color strength, light fastness, and other desirable features.

Background:
New direct dyes with antimicrobial activities for Gram-positive, Gram-negative bac-teria, and fungus are being developed. These dyes are used on cotton, silk, and wool materials, which have excellent light fastness, washing, rubbing, and perspiration fastness.

Methods:
All dyeing fabrics were tested for antibacterial activity. As a part of the experiment, parent structure 1 was previously synthesized. Then, diazotization and coupling reactions were used to prepare these dyes.

Results and Discussion:
P-Aminobenzenesulfonic acid (C1) and 4-Aminoazobenzene-3,4'-disul-fonic acid (C2) were diazotized in hydrochloric acid with sodium nitrite and then coupled with compound 1 in a molar ratio of 1:1 at 25 °C until the pH was fixed at 5. Finally, the monoazo and diazo direct dyes (D1 and D2) were prepared.

Conclusion:
Wool, silk, and cotton materials benefit from the increased antibacterial activities and dyeing qualities (exhaustion and fixing) of synthetic dyes. Furthermore, they offer excellent fast-ness qualities (light, rubbing, and perspiration).
Thymol and its Derivatives for Management of Phytopathogenic fungi of
Maize
Authors: Gaba Jyoti , Sharma Sunita , Kaur Harleen , Kaur Pardeep 
Published: December 2021

Background:
Thymol is a bioactive compound having many pharmacological activities.

Objective:
The present study was carried out to evaluate the fungi toxic effects of thymol and derivatives
against phytopathogenic fungi of maize.

Method:
Thymol was derivatized to get formylated thymol, Mannich bases, and imine derivatives.
All the synthesized thymol derivatives were characterized by their physical and spectral properties.
Synthesized thymol derivatives were screened for their in vitro antifungal effects using poisoned
food technique against three maize pathogenic fungi, namely Fusarium moniliforme, Rhizoctonia
solani and Dreschlera maydis.

Results:
Thymol and formylated thymol showed promising results for control of D. maydis with
ED50 values less than standard carbendazim and comparable to standard mancozeb. These two
compounds were further evaluated for control of D. maydis causative maydis leaf blight disease on
maize plants grown in the field during the Kharif season (June to October) 2018.

Conclusion:
Thymol exhibited significant control of maydis leaf blight disease of maize and
emerged as a potential alternative to synthetic fungicides used in cereal crops.
Thalidomide Mitigates Apoptosis via Endoplasmic Reticulum Stress in
Diabetic Nephropathy
Authors: Zhang Hong-Xia , Yuan Jie , Li Rong-Shan 
Published: December 2021

Background:
Previous studies have shown that endoplasmic reticulum (ER) stress is related to the apoptosis in the development of diabetic nephropathy (DN) and thalidomide (Thd) has renal-protective effects by suppressing inflammation and proliferation of MCs in DN. However, the effect of Thd on the apoptosis of MCs in DN remains largely unclear. The present research is designed to explore the effect of Thd on apoptosis in DN and the related mechanisms.

Objective:
The study is designed to examine the effect and mechanism of Thd on apoptosis in type 2 diabetic mice and high glucose (HG)-induced MCs.

Method:
We first evaluated the ER stress markers and apoptosis-related proteins with the treatment of Thd in type 2 diabetic mice and MCs in vitro under HG conditions. MTT assay was used to assess cell viability. Additionally, we evaluated the effect of Thd treatment upon MC apoptosis through flow cytometry. Real-time polymerase chain reaction (RT-PCR) and Western blot were performed to evaluate genes and protein expression related to ER stress and apoptosis.

Results:
The levels of blood urea BUN, CREA, Urine albumin, and UACR in diabetic mice were observed to be significantly reduced after 8 weeks of intervention with Thd. And also, there were upregulated glucose-regulated protein 78 (GRP78), Caspase-12, and downregulated B-cell lymphoma 2 (Bcl-2) in glomeruli of DN mice. In vitro, compared with the HG group, MC apoptosis reduced dramatically with Thd treatment along with upregulation of Bcl-2 and downregulation of Bax. At the same time, ER stress markers GRP78, C/EBP homologous protein (CHOP), and Caspase-12 were also mitigated following the Thd treatment.

Conclusion:
The present study indicates that Thd might reduce the ER stress in DN via downregulating GRP78, CHOP, and Caspase12 expressions, ultimately mitigating MCs apoptosis.
Review of Subdivision Schemes and their Applications
Authors: Shou Huahao , Liu Yan , Ji Kangsong 
Published: December 2021

Background:
Methods of subdivision surfaces modeling and related technology research
have become a hot spot in the field of Computer-Aided Design (CAD) and Computer Graphics
(CG). In the early stage, research on subdivision curves and surfaces mainly focused on the relationship
between the points, thereby failing to satisfy the requirements of all geometric modeling. Considering
many geometric constraints is necessary to construct subdivision curves and surfaces for
achieving high-quality geometric modeling.

Objective:
This paper aims to summarize various subdivision schemes of subdivision curves and
surfaces, particularly in geometric constraints, such as points and normals. The findings help scholars
to grasp the current research status of subdivision curves and surfaces better and explore their
applications in geometric modeling.

Methods:
This paper reviews the theory and applications of subdivision schemes from four aspects.
We first discuss the background and key concept of subdivision schemes and then summarize the
classification of classical subdivision schemes. Next, we review the subdivision surfaces fitting and
summarize new subdivision schemes under geometric constraints. Applications of subdivision surfaces
are also discussed. Finally, this paper provides a brief summary and future application prospects.

Results:
Many research papers and patents on subdivision schemes are classified in this review paper.
Remarkable developments and improvements have been achieved in analytical computations
and practical applications.

Conclusion:
Our review shows that subdivision curves and surfaces are widely used in geometric
modeling. However, some topics need to be further studied. New subdivision schemes need to be
presented to meet the requirements of new practical applications.
A Mini-review on Nanostructured g-C3N4 Photocatalysts for Solar Fuel
Production
Authors: Akple Maxwell Selase , Takyi Gabriel Kwame Sipi 
Published: December 2021

Abstract:
Graphitic carbon nitride (g-C3N4) is an important photocatalytic material that is receiving a lot
of research attention globally due to its favourable thermal and chemical stability as well as electronic
band structure. However, the photocatalytic performance of the bulk g-C3N4 is limited by fast recombination
of electron-hole pair and poor visible light-harvesting ability. Thus, different strategies, such as heterostructuring,
nanotuning, doping, etc., have been adopted to overcome the aforementioned challenges to
enhance the photocatalytic performance of g-C3N4. In recent times, various nanostructured g-C3N4 photocatalytic
materials with various tuned morphologies have been designed and fabricated in literature for
different photocatalytic activities. This mini-review summarized the progress development of nanostructured
g-C3N4 photocatalysts with various tuned morphologies for solar fuel generation. This article briefly
highlights the research status of various g-C3N4 with tuned morphologies and enhanced solar fuel generation
abilities. Finally, a conclusion and future research were also suggested, opening up new areas on g-
C3N4 photocatalysis.
Application of Metal-organic Framework Materials (MOFs) in the
Photocatalytic CO2 Reduction: A Mini-Review
Authors: Liu Yuanyuan , Jing Guolin , Zhang Huibo , Liu Yang , Yang Yihai , Xu Jianqi 
Published: December 2021

Abstract:
In recent years, the effective use of CO2 has become one of the research hotspots worldwide to solve environmental pollution and energy shortage, whose excessive emission led to increasingly serious global environmental problems. Metal-organic frameworks (MOFs), with extraordinary specific surface areas, tunable surface chemistry, fast electron migration rate, large CO2 adsorption capacity, etc． are a new class of functional materials composed of metal ions/clusters and organic ligands, which have broad application potential in CO2 photocatalytic reduction. This paper systematically generalized the composition of the structure, discussed the methods of synthetics and expounded the photocatalytic properties and photocatalytic mechanism of MOFs. In addition, the application and research progress of MOFs functional materials in recent research are reviewed. The article also summarized challenges and prospects for the large-scale photocatalytic applications of MOFs catalysts. It guides the preparation of novel modified MOFs photocatalysts for high-efficiency applications in the field of CO2 reduction and photocatalytic degradation of dyes.
The Effect of Video Game–Based Interventions on Performance and Cognitive Function in Older Adults: Bayesian Network Meta-analysis
Authors: Yang Chao , Han Xiaolei , Jin Mingxue , Xu Jianhui , Wang Yiren , Zhang Yajun , Xu Chonglong , Zhang Yingshi , Jin Enshi , Piao Chengzhe 
Published: December 2021

Background
The decline in performance of older people includes balance function, physical function, and fear of falling and depression. General cognitive function decline is described in terms of processing speed, working memory, attention, and executive functioning, and video game interventions may be effective.

Objective
This study evaluates the effect of video game interventions on performance and cognitive function in older participants in terms of 6 indicators: balance function, executive function, general cognitive function, physical function, processing speed, and fear of falling and depression.

Methods
Electronic databases were searched for studies from inception to June 30, 2020. Randomized controlled trials and case-controlled trials comparing video game interventions versus nonvideo game control in terms of performance and cognitive function outcomes were incorporated into a Bayesian network meta-analysis. All data were continuous variables.

Results
In total, 47 studies (3244 participants) were included. In pairwise meta-analysis, compared with nonvideo game control, video game interventions improved processing speed, general cognitive function, and depression scores. In the Bayesian network meta-analysis, interventions with video games improved balance function time (standardized mean difference [SMD] –3.34, 95% credible interval [CrI] –5.54 to –2.56), the cognitive function score (SMD 1.23, 95% CrI 0.82-1.86), processing speed time (SMD –0.29, 95% CrI –0.49 to –0.08), and processing speed number (SMD 0.72, 95% CrI 0.36-1.09), similar to the pairwise meta-analysis. Interventions with video games with strong visual senses and good interactivity ranked first, and these might be more beneficial for the elderly.

Conclusions
Our comprehensive Bayesian network meta-analysis provides evidence that video game interventions could be considered for the elderly for improving performance and cognitive function, especially general cognitive scores and processing speed. Games with better interactivity and visual stimulation have better curative effects. Based on the available evidence, we recommend video game interventions for the elderly.

Trial Registration
PROSPERO CRD42020197158; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197158