bluuebunny/crossref_metadata_2025_split huggingface dataset:
Batuques e toadas em linhagens discursivas
Authors: Carmo Bougleux Bomjardim da Silva 
Published: October 2021

O presente estudo focaliza a relação de interdependência entre linguagem e memória, na qual o sujeito falante exprime sua historicidade em práticas linguageiras. Diante disso, descreve-se as marcas interativas no processo de narrativização das lembranças em uma conversação com pessoas idosas. Neste contexto, analisa-se os efeitos, notadamente, dos marcadores discursivos e do relevo na construção tópica do discurso. A descrição e análise ancoram-se na perspectiva da Gramática Textual-Interativa (JUBRAN, 2015; KOCH, 2015), especificamente, nos conceitos de tópico discursivo (JUBRAN, 2015), relevo (TRAVAGLIA, 2015) e marcadores discursivos (RISSO, 2015; URBANO, 2015) em diálogo com estudos sociodiscursivos e cognitivos da memória (COURTINE, 2006; PAVEAU, 2015; PAVEAU, 2007). Metodologicamente, utiliza-se como corpus uma conversa de 17 minutos entre três velhos da comunidade Arara em Teixeira de Freitas (BA), transcrita conforme Preti (2005) para destaque da articulação discursivo-pragmática entre a lembrança e narrativa a partir da multifuncionalidade dos marcadores e recursos de relevo. Como resultado, mostra-se as funções metatextuais, precipuamente, do relevo emocional, reforço entonacional e dêiticos favorecendo a organização tópica de forma colaborativa, bem como o uso de marcadores discursivos interacionais exprimindo chamada à atenção, responsividade e processamento on-line da informação, oriunda das lembranças evocadas na memória sociocognitiva. Ressalta-se, a partir de Payer (2005) e Courtine (2006), a importância da função histórica da oralidade e busca-se explicitar o papel da memória na organização do discurso falado, já que linguagem e memória operam e se imbricam nas relações sociais e entre sujeitos históricos por meio de pré-discursos em diferentes linhagens discursivas (PAVEAU, 2015).
Rhino-orbital-cerebral mucormycosis in times of COVID-19: A neurosurgical experience
Authors: Singh Hershdeep , Dua Sanjeev , Goel Amitabh , Dhar Anil , Bhadauria Vikram , Garg Amit , Katyar Vikrant , Sharma Sumit , Shukla Aditi 
Published: October 2021

Background:
The gravity of “second wave” of COVID-19 has effaced many new challenges in India; mucormycosis being a recent one. Diabetes mellitus (DM) is a known significant risk factor for mucormycosis. Here, we present our experience with rhino-orbital-cerebral mucormycosis (ROCM) during the “second wave of COVID-19” at a tertiary health care centre in North India.

Methods:
This case series includes four cases of ROCM that were managed by our neurosurgical team in view ofcerebral involvement.

Results:
All the cases with an exception of one (Case 1), had a history of treatment for COVID-19 pneumonia. Case 2, 3 had undergone functional endoscopic sinus surgery (FESS) and orbital decompression before the onset of cerebral involvement; Case 4 underwent FESS and cranial surgery in the same sitting. All the patients had a history of DM and all the cases treated for COVID-19 pneumonia had a history of treatment with corticosteroids. Two patients underwent surgery with the exception of one patient, who did not provide consent for the same. One patient expired before surgical excision could be attempted.

Conclusion:
Regular and intensive follow-up is the key in swift detection and management of ROCM in post-COVID patients. While surgical excision is advisable in the fungal lesion, it must be borne in mind that radical excision of cerebral lesions is associated with morbidity, delayed recovery, and prolonged ICU stay. Culture and sensitivity-based antibiotics should be used judiciously as fever is a common postoperative complication. Blood sugar monitoring and control of DM are paramount in this condition. Steroids should be avoided in the management of cerebral edema with judicious use of hypertonic saline or mannitol.
Reflections on Music Performance and Dancing in a Roman Mosaic Found on the Aventine
Authors: NEİRA JİMÉNEZ Luz , RODRÍGUEZ Isabel 
Published: October 2021

This paper focuses on a figurative scene with musicians and dancers in one of the mosaics found in the grounds of Santa Sabina garden on the Aventine, currently preserved in the Vatican Museums. This representation has been the object of different interpretations and chronological analysis within the context of mime or, more recently, that of a banquet.
This contribution delves into whether, judging by the analysis of the iconography and literary sources, these are images that respond to a stereotyped repertoire or they reflect customary practices of that time. Finally, we will also reflect upon to what extent the representation of the protagonists of the event is reliable.
To address these questions, it has been necessary to date the mosaic to the beginning of the third century AD, establishing this chronology by comparing the geometric pattern of the mosaic with another found nearby, while also considering the revealing testimonies of contemporary authors, such as Clement of Alexandria.
Pengaruh Kepemimpinan, Budaya Organisasi Dan Lingkungan Kerja Terhadap Kinerja Karyawan Dengan Kepuasan Kerja Sebagai Variabel Intervening Di Qur’an Centre Provinsi Kepulauan Riau
Authors: Fathoni M Ilham , Indrayani Indrayani , Indrawan Mohamad Gita , Yanti Sri 
Published: October 2021

Tujuan penelitian ini untuk mengetahui pengaruh kepemimpinan, budaya organisasi dan lingkungan kerja terhadap kinerja karyawan dengan kepuasan kerja sebagai variabel intervening. Metode yang digunakan dalam penelitian ini adalah metode survei model kausal, pengumpulan data mengunakan kuesioner dan didistribusikan kepada 89 karyawan di Qur’an Centre Provinsi Kepulauan Riau. Analisis data statistik menggunakan SEM-PLS (Structural Equation Modelling-Partial Least Square) dan menggunakan analisis jalur untuk menguji pola hubungan yang mengungkapkan pengaruh variabel terhadap variabel lainnya, baik pengaruh langsung maupun tidak langsung. Hasil dalam penelitian menunjukkan bahwa kepemimpinan secara langsung berpengaruh signifikan terhadap kepuasan kerja karyawan dengan p-value sebesar 0,000 < 0,05, budaya organisasi secara langsung berpengaruh signifikan terhadap kepuasan kerja dengan p-value sebesar 0,001 < 0,05, lingkungan kerja secara langsung berpengaruh signifikan terhadap kepuasan kerja dengan p-value sebesar 0,001 < 0,05, kepemimpinan secara langsung berpengaruh signifikan terhadap kinerja karyawan dengan p-value sebesar 0,001 < 0,05, budaya organisasi secara langsung berpengaruh signifikan terhadap kinerja karyawan dengan p-value sebesar 0,000 < 0,05, lingkungan kerja secara langsung berpengaruh signifikan terhadap kinerja karyawan dengan p-value sebesar 0,000 < 0,05, kepuasan kerja secara langsung berpengaruh signifikan terhadap kinerja karyawan dengan p-value sebesar 0,006 < 0,05, kepuasan kerja memediasi pengaruh kepemimpinan terhadap kinerja karyawan dengan p-value 0,027 < 0,05, kepuasan kerja memediasi pengaruh budaya organisasi terhadap kinerja karyawan dengan p-value 0,027 < 0,05, dan kepuasan kerja memediasi pengaruh lingkungan kerja terhadap kinerja karyawan dengan p-value 0,041 < 0,05.
Monitoring Mitochondrial Partial Oxygen Pressure During Cardiac Arrest and Extracorporeal Cardiopulmonary Resuscitation. An Experimental Pilot Study in a Pig Model
Authors: Mandigers Loes , Pooth Jan-Steffen , Wefers Bettink Mark A. , Uil Corstiaan A. den , Damjanovic Domagoj , Mik Egbert G. , Brixius Sam , Gommers Diederik , Trummer Georg , dos Reis Miranda Dinis 
Published: October 2021

Introduction: Ischemia and reperfusion are crucial in determining the outcome after cardiac arrest and can be influenced by extracorporeal cardiopulmonary resuscitation (ECPR). The effect of ECPR on the availability and level of oxygen in mitochondria remains unknown. The aim of this study was to find out if skin mitochondrial partial oxygen pressure (mitoPO2) measurements in cardiac arrest and ECPR are feasible and to investigate its course.Materials and Methods: We performed a feasibility test to determine if skin mitoPO2 measurements in a pig are possible. Next, we aimed to measure skin mitoPO2 in 10 experimental pigs. Measurements were performed using a cellular oxygen metabolism measurement monitor (COMET), at baseline, during cardiac arrest, and during ECPR using the controlled integrated resuscitation device (CIRD).Results: The feasibility test showed continuous mitoPO2 values. Nine experimental pigs could be measured. Measurements in six experimental pigs succeeded. Our results showed a delay until the initial spike of mitoPO2 after ECPR initiation in all six experimental tests. In two experiments (33%) mitoPO2 remained present after the initial spike. A correlation of mitoPO2 with mean arterial pressure (MAP) and arterial partial oxygen pressure measured by CIRD (CIRD-PaO2) seemed not present. One of the experimental pigs survived.Conclusions: This experimental pilot study shows that continuous measurements of skin mitoPO2 in pigs treated with ECPR are feasible. The delay in initial mitoPO2 and discrepancy of mitoPO2 and MAP in our small sample study could point to the possible value of additional measurements besides MAP to monitor the quality of tissue perfusion during cardiac arrest and ECPR.
Multifocal and Microvascular Involvement in Ischemic Stroke During COVID-19: A Cohort Study With Comparison With Non-COVID-19 Stroke
Authors: Hautecloque Geoffroy , Kempf Christian , Stan Camélia , Arentz-Dugay Marie-Hélène , Vuillemet Francis , Ahle Guido , Sellal François , Martinot Martin 
Published: October 2021

Introduction: Thromboembolic events, including ischemic stroke, are major complications of coronavirus disease 2019 (COVID-19). The clinical characteristics of COVID-19-related stroke are not clearly defined, and few controlled studies assessed the underlying mechanisms of cerebrovascular complications of COVID-19. This single-center retrospective observational study compared stroke characteristics between patients with and without COVID-19.Methods: This study included all patients hospitalized between March 1, 2020, and April 30, 2020, in Colmar Hospital for ischemic stroke as confirmed by imaging. The characteristics of patients with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection by real-time reverse transcriptase polymerase chain reaction or serology were compared with those without SARS-CoV-2 infection.Result: Among 772 patients, nine COVID-19 patients were compared with 50 patients without COVID-19. The following inflammatory and procoagulant marker levels were significantly higher in the COVID-19 group than those in the control group: C-reactive protein, 57.3 ± 43.4 vs. 15.0 ± 30.6 mg/L, p &lt; 0.001; fibrinogen, 5.89 ± 1.75 vs. 4.03 ± 1.26 g/L, p &lt; 0.001; and D-dimer, 4,833.9 ± 6,549.4 vs. 1,028.6 ± 942.6 ng/ml, p &lt; 0.001. The rates of multifocal cerebral territory involvement (4 vs. 7, p = 0.05), microvascular involvement (4 vs. 6, p = 0.04), and thrombophilia (4 vs. 4, p = 0.014) were significantly higher in the COVID-19 group than in the control group, whereas no significant intergroup differences were found in the stroke mechanisms, i.e., cardio-embolic, atherosclerotic, small vessel disease, and cryptogenic.Conclusion: COVID-19-related stroke is characterized by hypercoagulability and hyperinflammation that may favor strokes via microvascular circulation abnormalities, microthrombus formation, and multifocal lesions.
Effects of Escitalopram on Endoplasmic Reticulum Stress and Oxidative Stress Induced by Tunicamycin
Authors: Yang Lixia , Chen ZhengHong , Li Jie , Ding PengJin , Wang Yiming 
Published: October 2021

Background: Major depressive disorder (MDD) was reported to be associated with endoplasmic reticulum stress (ERS) combined with oxidative stress (OS) (ERS/OS). Here, we aimed to investigate the effects of escitalopram (ESC) on blood-brain barrier (BBB) permeability and ERS/OS-related pathways in brain microvascular endothelial cells (bEnd.3 cells) induced by tunicamycin (TM).Methods: bEnd.3 cells were divided into four groups: control, TM, ESC, and ESC + TM groups. CCK-8 and flow cytometry were used to detect cell survival and apoptosis, respectively. The expression levels of proteins involved in cell permeability and ERS/OS-related pathways were assessed by western blot and immunofluorescence. Malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity were determined by commercial kits.Results: We revealed that TM-induced bEnd.3 cells exhibited remarkably decreased viability and increased apoptosis rate, while ESC treatment reversed these changes. Additionally, TM treatment resulted in markedly increased PERK, GRP78, ATF6, XBP1, and CHOP protein expression levels. On the contrary, the expression of PERK, GRP78, XBP1, and CHOP was obviously reduced in TM-induced bEnd.3 cells after ESC treatment. Moreover, TM significantly reduced the expression of p-eNOS and P-gp and increased the expression of CaMKII and MMP9 compared with the control group. However, ESC reversed these changes in TM-induced bEnd.3 cells. Furthermore, the expression of SOD was significantly decreased, while MDA was significantly increased by TM treatment. In contrast, the expression of SOD was dramatically increased, while MDA was remarkably decreased by ESC treatment.Conclusion: Our results demonstrated that ESC can inhibit ERS/OS and BBB permeability of TM-induced bEnd.3 cells. ESC may alleviate cognitive impairment and prevent comorbidities in MDD patients through ERS/OS.
Optimizing Whole Brain Radiotherapy Treatment and Dose for Patients With Brain Metastases From Small Cell Lung Cancer
Authors: Li Hanming , Li Wang , Qi Chao , Zhou Lu , Wen Fengyun , Qu Yanli , Yu Hong 
Published: October 2021

PurposeThis study aimed to evaluate the survival outcomes of whole brain radiotherapy (WBRT) compared to whole brain radiotherapy plus local radiation boost (WBRT + boost), and further identify whether higher biologically effective dose (BED) of WBRT + boost translates into a survival benefit in small cell lung cancer (SCLC) patients with brain metastasis (BM).MethodsSCLC patients with BM from January 1, 2012, to December 31, 2019, were retrospectively analyzed. Overall survival (OS) and intracranial progression-free survival (iPFS) were evaluated by the Kaplan–Meier method and compared by the log-rank test. Univariate and multivariate regression analyses of prognostic factors for OS were performed using Cox proportional hazards regression models. The cutoff value of BED was determined by the receiver operating characteristic (ROC) curve analysis.ResultsAmong the 180 eligible patients, 82 received WBRT + boost and 98 received WBRT. Both OS and iPFS in the WBRT + boost group were significantly superior to those in the WBRT group (median OS: 20 vs. 14 months, p = 0.011; median iPFS: 16 vs. 10 months, p = 0.003). At a cutoff value of 58.35 Gy in the WBRT + boost group, 52 for the high-BED (&gt;58.35 Gy) group, 30 for the low-BED (≤58.35 Gy) group. High BED was significantly associated with improved OS and iPFS compared with low BED in the WBRT + boost group (median OS: 23 vs. 17 months, p = 0.002; median iPFS: 17 vs. 10 months, p = 0.002).ConclusionsCompared with WBRT alone, WBRT + boost improved OS and iPFS in SCLC patients with BM. High BED (&gt;58.35 Gy) for WBRT + boost may be a reasonable consideration for SCLC patients with BM.
Upregulated Expression of Cancer-Derived Immunoglobulin G Is Associated With Progression in Glioma
Authors: Wang Guohui , Li Haonan , Pan Jie , Yan Tianfang , Zhou Huandi , Han Xuetao , Su Linlin , Hou Liubing , Xue Xiaoying 
Published: October 2021

ObjectiveGliomas are the most aggressive intracranial tumors accounting for the vast majority of brain tumors with very poor prognosis and overall survival (OS). Cancer-derived immunoglobulin G (cancer-IgG) has been found to be widely expressed in several malignancies such as breast cancer, colorectal cancer, and lung cancer. Cancer-IgG could promote tumorigenesis and progression. However, its role in glioma has not been revealed yet.MethodsWe mined open databases including the Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), and the Gene Expression Omnibus (GEO) to study the role ofIGHG1, which encodes cancer-IgG in glioma. Examination of the differential expression ofIGHG1was carried out in the GEO and TCGA databases. Furthermore, its expression in different molecular subtypes was analyzed. Stratified analysis was performed with clinical features. Subsequently, immune infiltration analysis was conducted using single-sample gene set enrichment analysis (ssGSEA). GSEA was performed to reveal the mechanisms ofIGHG1. Lastly, immunohistochemistry was processed to validate our findings.ResultsIn this study, we found that the expression ofIGHG1was higher in glioma and molecular subtypes with poor prognosis. The overall survival of patients with a high expression ofIGHG1was worse in the stratified analysis. Immune infiltration analysis indicated that the expression level ofIGHG1was positively correlated with the stromal score, ESTIMATE score, and immune score and negatively correlated with tumor purity. Results from the GSEA and DAVID demonstrated thatIGHG1may function in phagosome, antigen processing and presentation, extracellular matrix structural constituent, antigen binding, and collagen-containing extracellular matrix. Finally, immunohistochemistry assay validated our findings that patients with a high expression of cancer-IgG had poor OS and disease-free survival (DFS).ConclusionCancer-IgG is a promising biomarker of diagnosis and treatment for patients with glioma.
Comparative Study of Human and Murine Aortic Biomechanics and Hemodynamics in Vascular Aging
Authors: Hopper Sara E. , Cuomo Federica , Ferruzzi Jacopo , Burris Nicholas S. , Roccabianca Sara , Humphrey Jay D. , Figueroa C. Alberto 
Published: October 2021

Introduction: Aging has many effects on the cardiovascular system, including changes in structure (aortic composition, and thus stiffening) and function (increased proximal blood pressure, and thus cardiac afterload). Mouse models are often used to gain insight into vascular aging and mechanisms of disease as they allow invasive assessments that are impractical in humans. Translation of results from murine models to humans can be limited, however, due to species-specific anatomical, biomechanical, and hemodynamic differences. In this study, we built fluid-solid-interaction (FSI) models of the aorta, informed by biomechanical and imaging data, to compare wall mechanics and hemodynamics in humans and mice at two equivalent ages: young and older adults.Methods: For the humans, 3-D computational models were created using wall property data from the literature as well as patient-specific magnetic resonance imaging (MRI) and non-invasive hemodynamic data; for the mice, comparable models were created using population-based properties and hemodynamics as well as subject-specific anatomies. Global aortic hemodynamics and wall stiffness were compared between humans and mice across age groups.Results: For young adult subjects, we found differences between species in pulse pressure amplification, compliance and resistance distribution, and aortic stiffness gradient. We also found differences in response to aging between species. Generally, the human spatial gradients of stiffness and pulse pressure across the aorta diminished with age, while they increased for the mice.Conclusion: These results highlight key differences in vascular aging between human and mice, and it is important to acknowledge these when using mouse models for cardiovascular research.
Problems of modern philosophy teaching within the context of general psychology
Authors: Шелковников А.Ю. 
Published: October 2021

в статье говорится о необходимости психологической пропедевтики для преподавания философии в системе высшего образования. В качестве образца рассматривается система преподавания психологии и философии выдающегося русского философа Г.И. Челпанова (1862–1936). Статья может представлять интерес для философов, психологов, педагогов, студентов и аспирантов.
the article leads on the need for psychological propaedeutics for teaching philosophy within the higher education system. The system of psychology and philosophy teaching used by the outstanding Russian philosopher G.I. Chelpanov (1862–1936) has been studied as a model. The article may be of interest to philosophers, psychologists, educators, as well as undergraduate and graduate students.
Case Report: Human Bertiellosis—A Rare Cestode Infection in a South African Child
Authors: Naranbhai Nitesh , A. Singh Rochelle , Moodley Bhavani , Han Khine Swe Swe , Archary Moherndran , Mvelase Nomonde 
Published: October 2021

ABSTRACT.
Cestodes of Bertiella genus are parasites of nonhuman primates. We describe a rare case of human bertiellosis in South Africa: a 3-year-old girl with a 1-year history of rectal proglottid discharge and intermittent abdominal pain. After repeated failure with benzimidazole antihelminthic treatment, praziquantel proved successful.
Synthesis of novel nitrogen heterocycles bearing biological active carboxamide moiety as potential antitumor agents
Authors: B. Bakare S. 
Published: October 2021

ABSTRACT. In the present study, synthesis of a simple series of nitrogen heterocycles containing N-(p-bromophenyl) carboxamide moiety, such as benzimidazole, benzoxazine, oxadiazole and triazole compounds, by using 4-bromo aniline and diethyl oxalate as a key starting material has been described. Five nitrogen heterocycles compounds moiety were evaluated for their anticancer activity against MCF-7 cell line. The results revealed that compound 8 (N-(4-bromophenyl)-5-thioxo-1,3,4-oxadiazole-2-carboxamide) was the most potent cytotoxic activity. Cell cycle analysis demonstrated that compound 8 induce cell cycle arrest at G1 phase with apoptosis inducing activity marked by increase in G0 phase.

KEY WORDS: Synthesis, Nitrogen heterocycles, Carboxamide, Antitumor agents

Bull. Chem. Soc. Ethiop. 2021, 35(2), 449-459.
DOI: https://dx.doi.org/10.4314/bcse.v35i2.17
Veículo aéreo não tripulado como suporte à gestão de fluxos físicos em canteiros de obra
Authors: Sacramento Iran Carlos Caria , Campos Vanessa Rodrigues , Fernandes Vivian de Oliveira , Ferreira Emerson de Andrade Marques 
Published: October 2021

The present work intends to analyze the application of Unmanned Aerial Vehicle (UAV) as a tool to aid in the management of physical flows in small construction sites. This perspective is mainly aimed at reducing transportation losses, as well as activities that do not aggregate value, both based on the principles of Lean Construction. The methodological aspects of this research are related based on the application of a case study. The study in question used as an experimental field a small work located in the municipality of Camaçari, state of Bahia, involving the following methodological steps: (i) data collection: by means of survey, photographic record, observation of movements and use of UAV to obtain aerial photographs, (ii) diagnosis: in order to understand the current situation movements and disposal of materials) and (iii) proposal: which consists in the elaboration of a new site layout. The products prepared for the respective analyzes were thematic and georeferenced flow maps, whom, relate restrictively to the masonry execution service. The orthophotos obtained by the UAV were manipulated in Geographic Information System (GIS) software, allowing the identification of the distances walked by the workers in the execution of the analyzed service. The results indicated that the application of these tools can provide significant gains in reducing activities that do not aggregate value. In front of the proposed layout change, the construction site presented a reduction in transport losses of 41.8% in the ceramic block transport activity and 28.8% in the mortar transport activity, both related to the brick masonry service. The adopted method proved to be satisfactory for the understanding of the physical flow activities at the site in question, especially regarding the reduction of transport losses.