bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized controlled pilot study of a proprietary combination versus sunscreen in melasma maintenance
Authors: Chatterjee Manas , Neema Shekhar , Rajput Gopalsing Rameshsing 
Published: August 2021

Background:
Melasma is the commonest cause of facial hypermelanosis in skin type IV-VI. First-line treatment includes a triple combination containing topical corticosteroid and hydroquinone which have side effects on prolonged use. Chemical peels are a second-line management option with the laser being used in refractory cases, but the worsening of hyperpigmentation in darker skin types can occur following laser therapy. Sunscreen is a must to prevent relapses.

Aims and Objectives:
(i) To compare the effects of treatment with a proprietary combination (phenyl ethyl resorcinol, nonapeptide-1, aminoethyl phosphinic acid, antioxidants and sunscreen) versus sunscreen alone in limiting or reducing, melasma and preventing recurrence as a maintenance regimen after the initial use of triple combination,(ii) to evaluate the safety of the formulation studied, and (iii) to study the improvement of the quality of life of the patients after using the study formulation versus placebo.

Methods:
It was a prospective double-blinded parallel-group randomized controlled pilot study. A total of 46 subjects were recruited by consecutive sampling methods and randomized to 23 each in case and control groups. The study period was eight months with three phases. Phase 1 constituted the application of triple combination for eight weeks by both groups followed by phase 2 with the case group applying proprietary medicine and the control group applying sunscreen. Phase 3 was a follow-up period to see the sustenance of results in both groups as well as any evidence of relapses. Sunscreen was applied in all three phases.

Results:
Case group in the study showed improvement in the melasma severity score and mean melanin index as measured by mexameter but it did not attain statistical significance as compared to the control group. The melasma area and severity index score showed a consistent reduction in the case group, whereas it increased in the control group from baseline.

Limitations:
Small sample size and a short follow-up period of our study were major limitations.

Conclusion:
The proprietary combination, which has sunscreen as one of its constituents, is more effective in maintaining remission after triple combination without any added inconvenience of application of two separate preparations as compared to sunscreen alone.
Resveratrol
Authors: Пальцын А.А. 
Published: August 2021

Ресвератрол (Resveratrol) - природный плохо растворимый полифенол. Синтезируется многими растениями, название получил по растению, из которого был впервые выделен: Veratrum grandiflorum. Считается, что Ресвератрол в растениях выполняет функцию защиты от бактерий, грибов, ультрафиолета. Очень популярный и спорный объект медицинских исследований и публикаций. «Подозревается» во многих профилактических и лечебных действиях. Каждый год последнего десятилетия о Р появляется более тысячи сообщений, нередко с противоречащими результатами. Данный обзор - попытка выбрать для читателя по возможности достоверную и медицински значимую информацию.
Resveratrol is a natural, poorly soluble polyphenol. Resveratrol is synthesized by many plants and was named after the plant, from which it was originally isolated, Veratrum grandiflorum. Resveratrol is considered protective against bacteria, fungi, and ultraviolet. It is a very popular and disputable subject of medical studies and publications. It is «suspected» in many preventive and curative actions. Each year over the past decade, more than a thousand reports of resveratrol have been published, often with conflicting results. This review is an attempt to choose for the reader, to the extent possible, reliable and medically relevant information.
The role and interaction of polymorphic variants of non-allelic genes ADIPOQ, MTHFR, PON1, KCNJ11, TCF7L2, ITLN1, PPARG in the increase in the risk of obesity in Kyrgyz Republic
Authors: Исакова Ж.Т. , Кипень В.Н. , Акынбек Кызы Самара , Айтбаев К.А. , Алдашева Н.М. , Талайбекова Э.Т. , Мукеева С.Б. , Осмонкул Кызы Мээрим , Бейшеналиева С.Т. , Миррахимов Э.М. 
Published: August 2021

Цель исследования - оценить вклад полиморфных вариантов g.15661G> T (ген ADIPOQ), p.A222V (ген MTHFR), p.Q192R (ген PON1), p.K23E (ген KCNJ11), g.53341C>T (ген TCF7L2), p.V109D (ген ITLN1) и p.P12A (ген PPARG) в развитие ожирения для лиц кыргызской национальности. Исследование было проведено по типу «случай-контроль» и включало 130 пациентов с ожирением (мужчин - 65 (50,0%), женщин - 65 (50,0%)). Группа сравнения - 115 человек без ожирения, метаболических нарушений и сердечно-сосудистых заболеваний в анамнезе (мужчин - 62 (53,9%), женщин - 53 (46,1%). Генотипирование осуществляли методом ПЦР-ПДРФ. Анализ межгенных взаимодействий проводился с использованием программы MDR 3.0.2. Маркерами развития ожирения в кыргызской популяции являются аллель V и генотип VV локуса p.A222V (MTHFR), а также аллель K и генотип KK локуса p.K23E (KCNJ11). При наличии генетического профиля AV (p.A222V, MTHFR) / EK (p.K23E, KCNJ11) вероятность развития ожирения возрастает более чем в 3 раза, ОШ=3,49, 95% ДИ=[1,44-8,45], p=0,001.
In this study, we investigated whether polymorphisms g.15661G>T (ADIPOQ), p.A222V (MTHFR), p.Q192R (PON1), p.K23E (KCNJ11), g.53341C>T (TCF7L2), p.V109D (ITLN1) and p.P12A (PPARG) are associated with obesity in the Kyrgyz population. We genotyped 245 nonrelated adults Kyrgyz individuals. 130 patients (male - 65 (50,0%), female - 65 (50,0%) with obesity and 115 non-obese control subjects (male - 62 (53,9%), female - 53 (46,1%). Genotyping of single-nucleotide polymorphism was performed by PCR-RFLP method. Analysis of intergenic interactions conducted with MDR v.3.0.2 program. Тhe V allele and the VV genotype of the p.A222V locus (MTHFR), as well as the K allele and the KK genotype of the p.K23E locus (KCNJ11) increase risk of obesity in the Kyrgyz population. Subjects having the VV genotype of p.A222V locus (MTHFR) and KK genotype of the p.K23E locus (KCNJ11) had 3-fold [OR = 3,49 (1,44-8,45); p = 0,001] higher risk of developing compared with subjects carrying neither of these genotypes.
Medicinal peptide drugs in evidence-based medicine
Authors: Хавинсон В.Х. , Попович И.Г. , Рыжак Г.А. , Сафарова Г.Л. , Вершинина Е.А. 
Published: August 2021

Статья посвящена обзору исследований эффективности и безопасности пептидных лекарственных препаратов с точки зрения доказательной медицины. В отношении лекарственных средств доказательная медицина опирается на анализ информации, полученной в процессе оценки преимуществ и рисков при проведении клинических испытаний, в частности, рандомизированных двойных слепых плацебо-контролируемых исследований. На основании систематизированного подхода проводится мета-анализ, который представляет собой обобщение и статистический анализ результатов нескольких исследований. Обзор выполненных статистических исследований показал безусловную клиническую эффективность лекарственных пептидных препаратов
The article reviews the efficacy and safety of medicinal peptide drugs from the perspective of evidence-based medicine. With regard to medicinal drugs, evidence-based medicine relies on the analysis of information obtained by assessing the benefits and risks of clinical trials and, in particular, randomized double-blind placebo-controlled trials. Based on a systematic review, a meta-analysis, which is a summary and statistical analysis of the results of multiple studies, was performed. This analysis of reported statistical studies proved the unconditional clinical efficacy of medicinal peptide drugs.
Rate of convergence and error estimates for finite-difference schemes of solving linear ill-posed Cauchy problems of the second order
Authors: Кокурин М.М. 
Published: August 2021

Изучаются конечно-разностные схемы решения некорректных задач Коши для линейного дифференциально-операторного уравнения второго порядка в банаховом пространстве. Получены равномерные по времени оценки скорости сходимости и погрешности этих схем при наложении на искомое решение условия истокопредставимости. Найдены близкие друг к другу необходимые и достаточные условия в терминах показателя истокопредставимости для сходимости класса схем со степенной скоростью относительно шага дискретизации. Построены и изучены схемы
полной дискретизации некорректных задач Коши второго порядка, сочетающие полудискретизацию по времени с дискретной аппроксимацией пространства и оператора.
Finite-difference schemes of solving ill-posed Cauchy problems for linear second-order differential operator equations in Banach spaces are considered. Several time-uniform rate of convergence and error estimates are obtained for the considered schemes under the assumption that the sought solution satisfies the sourcewise condition. Necessary and sufficient conditions are found in terms of sourcewise index for a class of schemes with the power convergence rate with respect to the discretization step. A number of full discretization schemes for second-order ill-posed Cauchy problems are proposed on the basis of combining the half-discretization in time with the discrete approximation of the spaces and the operators.
Numerical algorithms without saturation for the Schroedinger equation of hydrogen atom
Authors: Алгазин С.Д. 
Published: August 2021

Математически проблема сводится к задаче на собственные значения для оператора Лапласа во всем пространстве с кулоновским потенциалом. Для численного решения этой задачи применяется новый математический аппарат,
разработанный автором. Инверсией относительно единичной сферы задача сводится к проблеме собственных
значений в проколотом в центре единичном шаре. Граничное условие в бесконечности (нулевое) переходит в центр шара. В шаре можно исключить периодическую переменную $\varphi$ и построить дискретизацию, наследующую свойство разделения переменных дифференциального оператора ($h$-матрица). По $\varphi$ выбиралось 11 точек. Клетки $\Lambda_0$, $\Lambda_1$, $\Lambda_2$, $\Lambda_3$, $\Lambda_4$ и $\Lambda_5$ в $h$-матрице соответствуют линиям Lyman, Balmer, Paschen, Brackett, Pfund и Humphreys. Из рассмотрения, представленных расчетов видим, что $\alpha$-линия Lyman определена с точностью $5.43\%$. Таким образом, совпадение результатов расчетов с теоретическими значениями удовлетворительное.
Mathematically, the problem under consideration is reduced to the eigenvalue problem for the Laplace operator in the entire space with the Coulomb potential. The new mathematical apparatus developed by the author is applied to the numerical solution of the reduced problem. This problem is reduced to the eigenvalue problem in the unit ball punctured at the center after inversion with respect to the unit sphere. The null boundary condition at infinity is transformed to the condition at the
center of the unit sphere. In the sphere it is possible to split off the periodic variable $\varphi$ and to construct the discretization inheriting the property of the separation of variables of the differential operator (the $h$-matrix). Eleven points is chosen based on the values of $\varphi$. The blocks $\Lambda_0$, $\Lambda_1$, $\Lambda_2$, $\Lambda_3$, $\Lambda_4$, and $\Lambda_5$ of the $h$-matrix correspond to the Lyman, Balmer, Paschen, Brackett, Pfund, and Humphreys lines. From the obtained numerical results, it follows that the Lyman-alpha line is determined with the accuracy equal to 5.43\%. Thus, the coincidence of the numerical results with the theoretical values is satisfactory.
A special variant of the subdomain method for solving the Fredholm integral equations of the second kind
Authors: Соловьева С.А. 
Published: August 2021

Предложен и теоретически обоснован специальный вариант метода подобластей на базе полиномов Канторовича приближенного решения интегральных уравнений Фредгольма второго рода в пространстве гладких функций.
A special variant of the subdomain method based on Kantorovich polynomials is proposed and theoretically substantiated for the approximate solution of Fredholm integral equations of the second kind in the space of smooth functions.
Distribution of computations in hybrid computing systems when translating NORMA language programs
Authors: Андрианов А.Н. , Баранова Т.П. , Бугеря А.Б. , Ефимкин К.Н. 
Published: August 2021

Рассмотрены методы распределения вычислительной нагрузки при трансляции программ с непроцедурного (декларативного) языка НОРМА в исполняемые программы для различных параллельных архитектур. Приведены краткие характеристики языка НОРМА и основные возможности компилятора программ на языке НОРМА. Описаны способы автоматического распределения вычислительной нагрузки при генерации исполняемых программ следующих типов: OpenMP, NVIDIA CUDA, MPIOpenMP и MPIOpenMPNVIDIA CUDA. Рассмотрена задача динамической балансировки вычислительной нагрузки, возникающая в случае неоднородной вычислительной среды MPIOpenMPNVIDIA CUDA, и предложен метод ее решения. Приведены результаты практического применения компилятора программ на языке НОРМА для решения двух различных задач и оценена скорость выполнения получаемых при этом исполняемых программ для различных параллельных архитектур.
The methods of computational load distribution when translating programs from the nonprocedural (declarative) NORMA language into executable programs for various parallel architectures are discussed. Some brief characteristics of the NORMA language and the main features of the compiler for programs in NORMA language are given. The methods of automatic distribution of computational load when generating executable programs of the following types are described: OpenMP, NVIDIA CUDA, MPIOpenMP, and MPIOpenMPNVIDIA CUDA. The problem of dynamic computational load balancing arising in the case of the heterogeneous computing environment MPIOpenMPNVIDIA CUDA is considered and a method of solving it is proposed. The results of practical application of the compiler for the programs in NORMA language for solving two different mathematical problems are given and the performance of the resulting executable programs is estimated for various parallel architectures.
Numerical simulation of detonation wave propagation using a two-stage kinetics model of chemical reactions in the shock-attached frame
Authors: Порошина Я.Э. , Уткин П.С. 
Published: August 2021

Для численного исследования пульсирующей детонационной волны в рамках двухстадийной модели кинетики химических реакций в системе координат, связанной с фронтом лидирующей волны, разработан оригинальный вычислительный алгоритм. Для четырех известных режимов распространения детонации в рамках данной модели исследовано влияние порядка аппроксимации алгоритма, длины расчетной области, сеточного разрешения и типа граничного условия на дальней границе на результаты моделирования. Проведено сравнение характера пульсаций с результатами расчетов других авторов.
For the numerical study of a pulsating detonation wave using a two-stage kinetics model of chemical reactions in the shock-attached frame, a new numerical algorithm is proposed. For the four known modes of detonation wave propagation, the effect of the approximation order of the proposed numerical algorithm, the length of the computational domain, the grid resolution, and the type of the farfield boundary condition on the simulation results is analyzed in the framework of this model. The character of pulsations is compared with the numerical results obtained by a number of other authors.
Study of some mathematical models for nonstationary filtration processes
Authors: Гольдман Н.Л. 
Published: August 2021

Рассматриваются математические модели, связанные с изучением нестационарных процессов фильтрации в подземной гидродинамике. Они представляют собой нелинейные задачи для параболических уравнений с неизвестной функцией источника в правой части. Одна из постановок является системой, которая состоит из краевой задачи с граничными условиями первого рода и из уравнения, задающего закон изменения по времени искомой функции источника. В другой постановке соответствующая система включает в себя краевую задачу с граничными условиями второго рода. Указанные постановки существенно отличаются от обычных краевых задач для параболических уравнений. Цель исследования - установить для этих нелинейных параболических задач условия однозначной разрешимости в классе гладких функций на основе априорных оценок метода Ротэ.
We consider some mathematical models connected with the study of nonstationary filtration processes in underground hydrodynamics. These models involve nonlinear problems for parabolic equations with unknown source functions. One of the problems is a system consisting of a boundary value problem of the first kind and an equation describing a time dependence of the sought source function. In the other problem, the corresponding system is distinguished from the first one by boundary conditions of the second kind. These problems essentially differ from usual boundary value problems for parabolic equations. The aim of our study is to establish conditions of unique solvability in a class of smooth functions for the considered nonlinear parabolic problems. The proposed approach involves the proof of a priori estimates for the Rothe method.
Posicionamentos em formação profissional continuada: um estudo multimétodo longitudinal
Authors: Forcione Thais Lanutti , Barbato Silviane Bonaccorsi 
Published: August 2021

Este estudo de caso longitudinal teve por objetivo analisar a produção de significados em posicionamentos de profissional em formação continuada em serviço. Utilizou-se multimétodos qualitativos aplicados em 3 blocos anuais com entrevista aberta, mediada por objeto ou imagem e episódica, e escrita de cartas, submetidos Ã s análises dialógico-temática. Os resultados indicaram que o participante se organiza, estuda e aplica conhecimentos, atuando em equipe, com dedicação e responsabilidade, direcionada para o futuro. As interpretações de si, do outro e das situações são atualizadas em ações dinamogênicas qualificadas contextualizadas.
Por uma educação científica que problematize a mídia
Authors: Cardoso Danilo , Gurgel Ivã 
Published: August 2021

O objetivo do trabalho é defender que umas das finalidades mais importantes para o ensino de ciências é a de problematizar a mídia. Para isso, primeiramente é feita uma discussão teórica sobre a epistemologia e a educação freireana. Nela, dá-se destaque ao papel da problematização no processo de conscientização. Em seguida, é realizada uma discussão sobre o papel da mídia na sociedade, ressaltando-se seus usos políticos. A partir desta discussão faz-se uma revisão de artigos sobre Educação e Mídia e Mídias e Ensino de Ciências com o objetivo de destacar as principais potencialidades desta aproximação. Por fim, argumenta-se que somente uma educação científica que problematize a mídia permite uma formação cidadã e crítica.
Políticas de Autonomía Curricular y Mejora de la Escuela
Authors: Bolívar Antonio 
Published: August 2021

Las políticas de autonomía curricular son actualmente una tendencia internacional en las políticas educativas, con nuevos modos de regulación y de responsabilización de los establecimientos escolares como una vía prometedora para que todos los alumnos puedan conseguir un éxito educativo. En este trabajo se describe su sentido y razones de dichas políticas, contextos (construir capacidad interna, desarrollo organizacional), condiciones, así como sus efectos en la mejora. La autonomía curricular abre posibilitar ampliar la profesionalidad docente y una personalización de los aprendizajes. La contextualización y flexibilidad curricular, en el marco de una autonomía curricular, posibilita el éxito educativo para todos, junto a una personalización de los aprendizajes. Entre otros, se analiza el papel que debe jugar el liderazgo pedagógico así como hacer de la escuela un proyecto conjunto de acción, mediante una comunidad de aprendizaje profesional.
Morphobiological properties of Belarusian varieties of Korean chrysanthemum (<i>Chrysanthemum coreanum</i>)
Authors: Bazyleva N. A. , Gulis A. L. , Beinia V. A. , Tsekhanovich S. V. 
Published: August 2021

The assortment of floral and ornamental plants is annually replenished with new varieties of perennial floral plants. The group of late summer and autumn flowering perennials is one of the most popular in landscaping. Korean chrysanthemum (Chrysanthemum сoreanum) is one of the most promising crops for landscaping settlements in the Republic of Belarus, therefore, breeders of the Central Botanical Garden of the National Academy of Sciences of Belarus began to work with this group of small-flowered chrysanthemums.The article describes the results of breeding work, the purpose of which was to create local highly decorative varieties for our climatic zone. The method of free cross-pollination and subsequent selection from the obtained hybrid seedlings of the most promising forms were used in the work. The most significant features in the selection were the following: flowering time, winter hardiness, resistance to diseases and pests, as well as good vegetative reproduction. As a result, 4 domestic varieties of Korean chrysanthemum have successfully passed state variety testing and have been registered in the National List since 2020. Descriptions of these new varieties, their biometric parameters, decorative parameters and flowering times are provided.
Impact of lactic acid product on quality indices of raw meat for the smoked sausages production
Authors: Merzlov S. V. , Fedoruk N. N. , Andriichuk A. V. , Fedoruk Yu. V. , Nadtochii V. N. , Hrebelnyk O. P. , Kalinina H. P. , Polishchuk S. A. 
Published: August 2021

Conducted research pertains to technologies of animal products processing and the development of biotechnological methods for stabilizing microbial and enzymatic biological leaven for meat.Materials and Methods. The studies were conducted in the conditions of the Research Institute of Food and Animal Processing Technologies and Laboratory of Microbiological Research Methods, Department of Microbiology of Bila Tserkva National Agrarian University. Moisture retaining capacity and bacterial contamination of beef and pork were determined.Results. The effect of processing raw meat with lactic acid product – yogurt on the moisture retaining capacity was experimentally established. With the highest titratable acidity of yoghurt of 100-110 °T, the moisture retaining capacity of pork and beef was inferior to control on 2.13 and 1.29 % and amounted to 51.88 and 62.73 %. Under a titratable acidity of lactic acid beverage of 100-110 °T with total number of lactic acid bacteria on the surface of raw meat, it was 8.1×108 and 8.5×108, which prevailed samples with acidity level of 60-70 °T on 24.5 and 24.3 %.Conclusions. The results of studies have revealed the effect of processing raw meat by yogurt with different titratable acidity on moisture retaining capacity and bacterial contamination.
Contribution of mutual perceived support to the marital satisfaction of combat commander couples
Authors: Zitronblat Limor Zaks , Dekel Rachel 
Published: August 2021

LAY SUMMARY Military combat commander couples face many difficulties, and support, especially perceived support, can be an important source for coping with them. This study examined how perceived support contributes to marital satisfaction among 248 male combat commanders in the Israel Defense Forces and their female spouses. The study found that the level of perceived support among combat commanders was significantly higher than that among their spouses, whereas there was no significant difference in their marital satisfaction.