bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexuelle Unlust – Wirkmechanismen des natürlichen Aphrodisiakums Damiana (Turnera diffusa)
Authors: Kuchernig Jennifer-Christin 
Published: June 2021

ZusammenfassungSexuelle Unlust bei Frauen ist eine häufig auftretende und meist multifaktorielle Symptomatik in jedem Alter. Entsteht daraus ein individueller Leidensdruck, einhergehend mit einer schlechten Lebensqualität, dann leiden Frauen daran umfassender und möglicherweise schwerwiegender als Männer. Ihre sexuellen Probleme werden jedoch im klinischen Umfeld oft nicht erkannt und bleiben unbehandelt, denn nur 20–34 % der Betroffenen suchen aktiv Hilfe bei einem Arzt. Die Auslöser mangelnder Libido können vielfältig sein und neben stressigen Lebensphasen auch an bestehende Medikationen, den demografischen Hintergrund, Probleme in der Partnerschaft oder Umstellungen der Hormone z. B. in den Wechseljahren gekoppelt sein. Pharmakotherapeutisch stehen jedoch nur relativ wenige Optionen für die Behandlung zur Verfügung. Neben einer nur in der Off-Label-Anwendung möglichen Verabreichung von transdermalem Testosteron oder Dehydroepiandrosteron, der Überweisung an andere Fachgebiete oder einer interdisziplinären Zusammenarbeit kann ein möglicher Baustein der Behandlung in der Verwendung geeigneter Phytopharmaka liegen. Durch eine Gesamtwirkung der beobachteten Einzelwirkungen von Inhaltsstoffen der Pflanze Damiana (Turnera diffusa) aus der Familie der Safranmalven (Turneraceae) können daraus hergestellte Arzneimittel eine gute Behandlungsoption mit einem positiven Einfluss auf eine verminderte Libido darstellen.
APPLYING ECONOMIC MEASURES TO LAPSE RISK MANAGEMENT WITH MACHINE LEARNING APPROACHES
Authors: Loisel Stéphane , Piette Pierrick , Tsai Cheng-Hsien Jason 
Published: June 2021

AbstractModeling policyholders’ lapse behaviors is important to a life insurer, since lapses affect pricing, reserving, profitability, liquidity, risk management, and the solvency of the insurer. In this paper, we apply two machine learning methods to lapse modeling. Then, we evaluate the performance of these two methods along with two popular statistical methods by means of statistical accuracy and profitability measure. Moreover, we adopt an innovative point of view on the lapse prediction problem that comes from churn management. We transform the classification problem into a regression question and then perform optimization, which is new to lapse risk management. We apply the aforementioned four methods to a large real-world insurance dataset. The results show that Extreme Gradient Boosting (XGBoost) and support vector machine outperform logistic regression (LR) and classification and regression tree with respect to statistic accuracy, while LR performs as well as XGBoost in terms of retention gains. This highlights the importance of a proper validation metric when comparing different methods. The optimization after the transformation brings out significant and consistent increases in economic gains. Therefore, the insurer should conduct optimization on its economic objective to achieve optimal lapse management.
Predicted Number of Pregnant Women in Aichi Prefecture, Japan: Estimation by Machine Learning Database Construction for Disaster Preparation
Authors: Hattori Kanetoshi , Hattori Ritsuko 
Published: June 2021

AbstractAichi prefecture, Japan is predicted to be hit by Mega-earthquake. Aichi Prefectural Association of Midwives has been making efforts to improve disaster preparedness for pregnant women. This project aims to acquire area data of pregnant women for simulated studies of rescue activities. Number of women in census survey areas in Nagoya City was acquired from nationwide data of pregnant women by machine learning (Cascade-Correlation Learning Architecture). Quite high correlation coefficients between actual data and estimation data were observed. Rescue simulations have been carried out based on the data acquired by this study.
On the temporal evolution of turbopause altitude, 1996–2021, 70°N, 19°E
Authors: Hall C. M. , Nozawa S. 
Published: June 2021

Abstract
Medium frequency radars with multiple receivers are able to track the movement of the interference pattern on the ground from echoes from irregularities in refractive index. In particular, refractive index in the mesosphere is determined by electron density – commonly known as the ionospheric D-region. Thus using this technique it is possible to determine winds in the height regime 70-90 km, depending on the degree of ionization throughout the year. In addition, by examining the fading times of the passage of these structures, it is possible to deduce metrics pertaining to neutral air turbulence. Here, we employ a well-established method to this effect. Thereafter, comparing the turbulent intensity to the kinematic viscosity of the neutral atmosphere, we determine the turbopause altitude. Above this height, atmospheric constituents behave independently, whereas below, all components are mixed. Contrary to earlier analyses, we present evidence the turbopause altitude has been constant since approximately 2004.
Is ‘conversion therapy’ tortious?
Authors: Purshouse Craig , Trispiotis Ilias 
Published: June 2021

AbstractSo-called ‘conversion therapy’ involves therapeutic attempts to change an individual's sexual orientation or gender identity. It is widely considered to be harmful to sexual minorities and there have been calls for it to be banned in the UK. In this paper, we examine whether victims of the practice could bring tort claims against ‘therapists’ for mental harm. Focusing on talking therapies, we assess tort doctrine in the law of negligence, the rule in Wilkinson v Downton, the Protection from Harassment Act 1997 and deceit. We conclude that while some forms of conversion therapy will be tortious, others will not and so this area of law may fail to assist many victims of the practice.
Hypothalamic regulation of energy homoeostasis when consuming diets of different energy concentrations: comparison between Tibetan and Small-tailed Han sheep
Authors: Jing Xiaoping , Guo Yamin , Degen Allan , Wang Wenji , Kang Jingpeng , Ding Luming , Shang Zhanhuan , Long Ruijun , Zhou Jianwei 
Published: June 2021

AbstractSeasonal energy intake of Tibetan sheep on the harsh Qinghai-Tibetan Plateau (QTP) fluctuates greatly and is often well below maintenance requirements. The aim of this study was to gain insight into how the hypothalamus regulates energy homoeostasis in Tibetan sheep. We compared Tibetan and Small-tailed Han sheep (n 24 of each breed), which were each allocated randomly into four groups and offered one of four diets that differed in digestible energy densities: 8·21, 9·33, 10·45 and 11·57 MJ/kg DM. Sheep were weighed every 2 weeks, and it was assumed that the change in body weight (BW) reflected the change in energy balance. The arcuate nucleus of the hypothalamus in Tibetan sheep had greater protein expressions of neuropeptide Y (NPY) and agouti-related peptide (AgRP) when in negative energy balance, but lesser protein expressions of proopiomelanocortin (POMC) and cocaine and amphetamine-regulated transcript (CART) when in positive energy balance than Small-tailed Han sheep. As a result, Tibetan sheep had a lesser BW loss when in negative energy balance and stored more energy and gained more BW when in positive energy balance than Small-tailed Han sheep with the same dietary intake. Moreover, in the hypothalamic adenosine monophosphate-activated protein kinase (AMPK) regulation pathway, Tibetan sheep had greater adenosine monophosphate-activated protein kinase-α 2 protein expression than Small-tailed Han sheep, which supported the premise of a better ability to regulate energy homoeostasis and better growth performance. These differences in the hypothalamic NPY/AgRP, POMC/CART and AMPK pathways between breeds conferred an advantage to the Tibetan over Small-tailed Han sheep to cope with low energy intake on the harsh QTP.
Smooth parameterizations of power-subanalytic sets and compositions of Gevrey functions
Authors: Van Hille Siegfried 
Published: June 2021

AbstractWe show that if $X$ is an $m$-dimensional definable set in $\mathbb {R}_\text {an}^\text{pow}$, the structure of real subanalytic sets with real power maps added, then for any positive integer $r$ there exists a $C^{r}$-parameterization of $X$ consisting of $cr^{m^{3}}$ maps for some constant $c$. Moreover, these maps are real analytic and this bound is uniform for a definable family.
The Last Hump: The Lahore Elementary Flying Training School, the Chinese Civil War, and the final days of the British Raj
Authors: CAO YIN 
Published: June 2021

AbstractThis article centres on the evacuation of the Lahore Elementary Flying Training School, which was built in 1943 to train Chinese pilots and mechanics. It details the British and Chinese authorities’ concerns over the school and how the chaotic situation in India during the final days of the British Raj influenced its evacuation back to China. This article locates the story within the broad context of the British withdrawal from India and the Chinese Civil War, and it uses this case to uncover the links between the two most significant events in the history of modern India and China. In so doing, it puts forward an integrated framework for studying modern Indian and Chinese history.
Nearly modern IPE? Insights from IPE at mid-century
Authors: Germain Randall 
Published: June 2021

AbstractDisciplinary debates within IPE often leave as an open question how contemporary scholars may build on and incorporate insights from its rich intellectual history. In this article I examine the work of three scholars who are rarely grouped together, but who should be recognised today as engaged in an IPE-inflected debate: Karl Polanyi, E. H. Carr, and David Mitrany. They advanced distinct IPE-centred ways of framing the central problems of the post-1945 world, which are remarkable for how they prefigure important themes in modern IPE scholarship. By assembling and considering their work collectively, I make two arguments: (1) we should recognise their contributions as a precursor to modern IPE; and (2) their work, with certain caveats, provides valuable intellectual resources for contemporary scholars. Their combined work should be considered as part of the common heritage of IPE.
A prenatal diagnosis of unusual aortopulmonary communication: tubular aortopulmonary window
Authors: Babaoğlu Kadir , Başar Eviç Zeynep , Türköz Rıza 
Published: June 2021

AbstractWe described a very rare case of aorto-pulmonary communication with right aortic arch and crossed pulmonary artery that cannot be placed in the typical anatomic classification of aortopulmonary window. At 23 weeks gestation, fetal echocardiography revealed a large tunnel-like communication connecting the great vessels proximal to the main pulmonary artery bifurcation, rather than a classic aortopulmonary window between the ascending aorta and the main pulmonary artery.
Characterising and monitoring preconception health in England: a review of national population-level indicators and core data sources
Authors: Schoenaker Danielle A.J.M. , Stephenson Judith , Connolly Anne , Shillaker Sally , Fishburn Sarah , Barker Mary , Godfrey Keith M. , Alwan Nisreen A. ,   the UK Preconception Partnership
Published: June 2021

AbstractInitiatives to optimise preconception health are emerging following growing recognition that this may improve the health and well-being of women and men of reproductive age and optimise health in their children. To inform and evaluate such initiatives, guidance is required on indicators that describe and monitor population-level preconception health. We searched relevant databases and websites (March 2021) to identify national and international preconception guidelines, recommendations and policy reports. These were reviewed to identify preconception indicators. Indicators were aligned with a measure describing the prevalence of the indicator as recorded in national population-based data sources in England. From 22 documents reviewed, we identified 66 indicators across 12 domains. Domains included wider (social/economic) determinants of health; health care; reproductive health and family planning; health behaviours; environmental exposures; cervical screening; immunisation and infections; mental health, physical health; medication and genetic risk. Sixty-five of the 66 indicators were reported in at least one national routine health data set, survey or cohort study. A measure of preconception health assessment and care was not identified in any current national data source. Perspectives from three (healthcare) professionals described how indicator assessment and monitoring may influence patient care and inform awareness campaign development. This review forms the foundation for developing a national surveillance system for preconception health in England. The identified indicators can be assessed using national data sources to determine the population’s preconception needs, improve patient care, inform and evaluate new campaigns and interventions and enhance accountability from responsible agencies to improve preconception health.
Sub‐Ice Platelet Layer Physics: Insights From a Mushy‐Layer Sea Ice Model
Authors: Wongpan P. , Vancoppenolle M. , Langhorne P. J. , Smith I. J. , Madec G. , Gough A. J. , Mahoney A. R. , Haskell T. G. 
Published: June 2021

AbstractThe sub‐ice platelet layer (SIPL) is a highly porous, isothermal, friable layer of ice crystals and saltwater, that can develop to several meters in thickness under consolidated sea ice near Antarctic ice shelves. While the SIPL has been comprehensively described, details of its physics are rather poorly understood. In this contribution we describe the halo‐thermodynamic mechanisms driving the development and stability of the SIPL in mushy‐layer sea ice model simulations, forced by thermal atmospheric and oceanic conditions in McMurdo Sound, Ross Sea, Antarctica. The novelty of these simulations is that they predict a realistic model analogue for the SIPL. Two aspects of the model are essential: (a) a large initial brine fraction is imposed on newly forming ice, and (b) brine rejection via advective desalination. The SIPL appears once conductive heat fluxes become insufficient to remove latent heat required to freeze the highly porous new ice. Favorable conditions for SIPL formation include cold air, supercooled waters, and consolidated ice and snow that are thick enough to provide sufficient thermal insulation. Thermohaline properties resulting from large liquid fractions stabilize the SIPL, in particular a low thermal diffusivity. Intense convection within the isothermal SIPL generates the SIPL‐consolidated ice contrast without transporting heat. Using standard physical constants and free parameters, the model successfully predicts the SIPL and consolidated ice thicknesses at six locations. While most simulations were performed with 50 layers, an SIPL emerged with moderate accuracy in thickness for three layers proving a low‐cost representation of the SIPL in large‐scale climate models.
Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection
Authors: Pu Qinqin , Guo Kai , Lin Ping , Wang Zhihan , Qin Shugang , Gao Pan , Combs Colin , Khan Nadeem , Xia Zhenwei , Wu Min 
Published: June 2021

AbstractBitter receptors function primarily in sensing taste, but may also have other functions, such as detecting pathogenic organisms due to their agile response to foreign objects. The mouse taste receptor type-2 member 138 (TAS2R138) is a member of the G-protein-coupled bitter receptor family, which is not only found in the tongue and nasal cavity, but also widely distributed in other organs, such as the respiratory tract, gut, and lungs. Despite its diverse functions, the role of TAS2R138 in host defense against bacterial infection is largely unknown. Here, we show that TAS2R138 facilitates the degradation of lipid droplets (LDs) in neutrophils during Pseudomonas aeruginosa infection through competitive binding with PPARG (peroxisome proliferator-activated receptor gamma) antagonist: N-(3-oxododecanoyl)-l-homoserine lactone (AHL-12), which coincidently is a virulence-bound signal produced by this bacterium (P. aeruginosa). The released PPARG then migrates from nuclei to the cytoplasm to accelerate the degradation of LDs by binding PLIN2 (perilipin-2). Subsequently, the TAS2R138–AHL-12 complex targets LDs to augment their degradation, and thereby facilitating the clearance of AHL-12 in neutrophils to maintain homeostasis in the local environment. These findings reveal a crucial role for TAS2R138 in neutrophil-mediated host immunity against P. aeruginosa infection.
Ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms
Authors: Schatz Daniella , Schleyer Guy , Saltvedt Marius R , Sandaa Ruth-Anne , Feldmesser Ester , Vardi Assaf 
Published: June 2021

Abstract
Extracellular vesicles are produced by organisms from all kingdoms and serve a myriad of functions, many of which involve cell-cell signaling, especially during stress conditions and host-pathogen interactions. In the marine environment, communication between microorganisms can shape trophic level interactions and population succession, yet we know very little about the involvement of vesicles in these processes. In a previous study, we showed that vesicles produced during viral infection by the ecologically important model alga Emiliania huxleyi, could act as a pro-viral signal, by expediting infection and enhancing the half-life of the virus in the extracellular milieu. Here, we expand our laboratory findings and show the effect of vesicles on natural populations of E. huxleyi in a mesocosm setting. We profile the small-RNA (sRNA) cargo of vesicles that were produced by E. huxleyi during bloom succession, and show that vesicles applied to natural assemblages expedite viral infection and prolong the half-life of this major mortality agent of E. huxleyi. We subsequently reveal that exposure of the natural assemblage to E. huxleyi-derived vesicles modulates not only host-virus dynamics, but also other components of the microbial food webs, thus emphasizing the importance of extracellular vesicles to microbial interactions in the marine environment.
Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism
Authors: Hernandez Lidia F. , Dull Angie B. , Korrapati Soumya , Annunziata Christina M. 
Published: June 2021

AbstractOvarian cancer is the most lethal gynecological cancer in the US. Standard treatment consists of surgery followed by chemotherapies relying on apoptotic tumor cell death. Most women with advanced stage disease will relapse, suggesting that this disease is characterized by primary and acquired resistance to chemotherapy, and novel approaches to treatment are greatly needed. Low Caspase 8 expression levels in ovarian cancers correlate with resistance to apoptotic chemotherapy, and a subpopulation of patients with low Caspase 8 levels exhibit poorer overall survival after standard-of-care treatment. We hypothesized that low Caspase 8 function reduces the ability of cancer cells to undergo apoptosis when exposed to standard chemotherapy and that second mitochondria-derived activator of caspases (Smac)-mimetics could increase cell death in combination with chemotherapy. Here we show that combination treatment with a Smac-mimetic can target tumor cells with low Caspase 8 and induce necroptotic cell death. We investigated the in vitro effect of Smac-mimetic added to carboplatin and paclitaxel treatment of ovarian cancer cells expressing wild type and low Caspase 8 levels, which resulted in a 2–4-fold enhancement of cell death. Mice bearing subcutaneous or intraperitoneal ovarian xenografts showed greater aggressiveness of Caspase 8-deficient versus wild-type tumors; combined in vivo treatment with chemotherapy and Smac-mimetic resulted in >50% decrease in low Caspase 8 xenograft growth, as well as significantly enhanced overall survival, especially when given simultaneously with paclitaxel. Surprisingly, Smac-mimetic on the same day as carboplatin decreased mouse survival compared to when it was given on a sequential day of treatment. The antagonism was associated with a decrease in DNA damage markers, emphasizing the importance of optimizing timing of drug administration. Clinical validation of such approaches is needed to increase the effectiveness of current standard ovarian cancer treatment.
Robust estimation of SARS-CoV-2 epidemic in US counties
Authors: Li Hanmo , Gu Mengyang 
Published: June 2021

AbstractThe COVID-19 outbreak is asynchronous in US counties. Mitigating the COVID-19 transmission requires not only the state and federal level order of protective measures such as social distancing and testing, but also public awareness of time-dependent risk and reactions at county and community levels. We propose a robust approach to estimate the heterogeneous progression of SARS-CoV-2 at all US counties having no less than 2 COVID-19 associated deaths, and we use the daily probability of contracting (PoC) SARS-CoV-2 for a susceptible individual to quantify the risk of SARS-CoV-2 transmission in a community. We found that shortening by $$5\%$$

5
%

of the infectious period of SARS-CoV-2 can reduce around $$39\%$$

39
%

(or 78 K, $$95\%$$

95
%

CI: [66 K , 89 K ]) of the COVID-19 associated deaths in the US as of 20 September 2020. Our findings also indicate that reducing infection and deaths by a shortened infectious period is more pronounced for areas with the effective reproduction number close to 1, suggesting that testing should be used along with other mitigation measures, such as social distancing and facial mask-wearing, to reduce the transmission rate. Our deliverable includes a dynamic county-level map for local officials to determine optimal policy responses and for the public to better understand the risk of contracting SARS-CoV-2 on each day.
Inhibition of epithelial–mesenchymal transition in retinal pigment epithelial cells by a retinoic acid receptor-α agonist
Authors: Kobayashi Yuka , Tokuda Kazuhiro , Yamashiro Chiemi , Higashijima Fumiaki , Yoshimoto Takuya , Ota Manami , Ogata Tadahiko , Ashimori Atsushige , Hatano Makoto , Kobayashi Masaaki , Uchi Sho-Hei , Wakuta Makiko , Kimura Kazuhiro 
Published: June 2021

AbstractEpithelial–mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells plays a key role in proliferative retinal diseases such as age-related macular degeneration by contributing to subretinal fibrosis. To investigate the potential role of retinoic acid receptor-α (RAR-α) signaling in this process, we have now examined the effects of the RAR-α agonist Am580 on EMT induced by transforming growth factor-β2 (TGF-β2) in primary mouse RPE cells cultured in a three-dimensional type I collagen gel as well as on subretinal fibrosis in a mouse model. We found that Am580 inhibited TGF-β2-induced collagen gel contraction mediated by RPE cells. It also attenuated the TGF-β2-induced expression of the mesenchymal markers α-smooth muscle actin, fibronectin, and collagen type I; production of pro-matrix metalloproteinase 2 and interleukin-6; expression of the focal adhesion protein paxillin; and phosphorylation of SMAD2 in the cultured RPE cells. Finally, immunofluorescence analysis showed that Am580 suppressed both the TGF-β2-induced translocation of myocardin-related transcription factor-A (MRTF-A) from the cytoplasm to the nucleus of cultured RPE cells as well as subretinal fibrosis triggered by laser-induced photocoagulation in a mouse model. Our observations thus suggest that RAR-α signaling inhibits EMT in RPE cells and might attenuate the development of fibrosis associated with proliferative retinal diseases.