bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manifestations of renal system involvement in hospitalized patients with COVID-19 in Saudi Arabia
Authors: Allemailem Khaled S. , Almatroudi Ahmad , Khan Amjad Ali , Rahmani Arshad H. , Almarshad Ibrahim S. , Alekezem Fahad S. , Hassanein Nagwa , El-Kady Asmaa M. 
Published: July 2021

BackgroundAlthough COVID-19 is an acute disease that usually resolves rapidly in most cases, the disease can be fatal and has a mortality rate of about 1% to 56%. Alveolar injury and respiratory failure are the main causes of death in patients with COVID 19. In addition, the effect of the disease on other organs is not fully understood. Renal system affection has been reported in patients with COVID 19 and is associated with a higher rate of diverse outcomes, including mortality. Therefore, in the present work, we reported the clinical characteristics and laboratory data of hospitalized patients with COVID-19 and analyzed the manifestations that indicated renal system involvement and their impact on clinical outcomes.Materials and methodsThis was an observational retrospective study conducted at King Fahd Specialist Hospital, Buraydah, Saudi Arabia. All patients with COVID-19 who were admitted to this Hospital from April to December 2020 were included in the study. The patients’ findings at presentation were recorded. Demographic data and laboratory results (hematuria, proteinuria, urinary sediment cast and pus cell presence, and kidney function tests) were retrieved from electronic patient records.ResultsOne hundred and ninety-three patients with confirmed COVID 19 were included in the study. Dipstick examinations of all urine samples showed proteinuria and hematuria in 53.9% and 22.3% of patients, respectively, whereas microscopic examination revealed the presence of pus and brown muddy granular casts in 33.7% and 12.4% of samples, respectively. Acute kidney injury was reported in 23.3% of patients. A multivariable analysis demonstrated that hematuria was associated with acute kidney injury (AKI) (OR, 2.4; 95% CI, 1.2–4.9;P= 0.001), ICU admission (OR, 3.789; 95% CI, 1.913–7.505;P =0.003), and mortality (OR, 8.084; 95% CI, 3.756–17.397;P =0.002). Conversely, proteinuria was less significantly associated with the risk of AKI (OR, 1.56; 95% CI, 1.91–7.50;P =0.003), ICU admission (OR, 2.493; 95% CI, 1.25–4.72;P =0.001), and mortality (OR, 2.764; 95% CI, 1.368–5.121;P =0.003). Patients with AKI had a higher probability for mortality than did those without AKI (OR, 14.208; 95% CI, 6.434–31.375;P =0.003).ConclusionThe manifestations of the involvement of the renal system are not uncommon in COVID-19. These manifestations included proteinuria, hematuria, and AKI and were usually associated with a poor prognosis, including high incidences of both ICU admission and mortality.
The Minimal Phenomenal Experience questionnaire (MPE-92M): Towards a phenomenological profile of “pure awareness” experiences in meditators
Authors: Gamma Alex , Metzinger Thomas 
Published: July 2021

Objective
To develop a fine-grained phenomenological analysis of “pure awareness” experiences in meditators.

Methods
An online survey in five language versions (German, English, French, Spanish, Italian) collected data from January to March 2020. A total of 92 questionnaire items on a visual analogue scale were submitted to exploratory and confirmatory factor analysis.

Results
Out of 3627 submitted responses, 1403 were usable. Participants had a median age of 52 years (range: 17–88) and were evenly split between men and women (48.5% vs 50.0%). The majority of meditators practiced regularly (77.3%), were free of diagnosed mental disorders (92.4%) and did not regularly use any psychoactive substances (84.0%). Vipassana (43.9%) followed by Zen (34.9%) were the most frequently practiced meditation techniques. German (63.4%) and English (31.4%) were by far the most frequent questionnaire languages. A solution with 12 factors explaining 44% of the total variance was deemed optimal under joint conceptual and statistical considerations. The factors were named “Time, Effort and Desire,” “Peace, Bliss and Silence,” “Self-Knowledge, Autonomous Cognizance and Insight,” “Wakeful Presence,” “Pure Awareness in Dream and Sleep,” “Luminosity,” “Thoughts and Feelings,” “Emptiness and Non-egoic Self-awareness,” “Sensory Perception in Body and Space,” “Touching World and Self,” “Mental Agency,” and “Witness Consciousness.” This factor structure fit the data moderately well.

Conclusions
We have previously posited a phenomenological prototype for the experience of “pure awareness” as it occurs in the context of meditation practice. Here we offer a tentative 12-factor model to describe its phenomenal character in a fine-grained way. The current findings are in line with an earlier study extracting semantic constraints for a working definition of minimal phenomenal experience.
Computational modeling of the cephalic arch predicts hemodynamic profiles in patients with brachiocephalic fistula access receiving hemodialysis
Authors: Hammes Mary , Moya-Rodriguez Andres , Bernstein Cameron , Nathan Sandeep , Navuluri Rakesh , Basu Anindita 
Published: July 2021

Background
The most common configuration for arteriovenous fistula is brachiocephalic which often develop cephalic arch stenosis leading to the need for numerous procedures to maintain access patency. The hemodynamics that contributes to the development of cephalic arch stenosis is incompletely understood given the inability to accurately determine shear stress in the cephalic arch. In the current investigation our aim was to determine pressure, velocity and wall shear stress profiles in the cephalic arch in 3D using computational modeling as tools to understand stenosis.

Methods
Five subjects with brachiocephalic fistula access had protocol labs, Doppler, venogram and intravascular ultrasound imaging performed at 3 and 12 months. 3D reconstructions of the cephalic arch were generated by combining intravascular ultrasounds and venograms. Standard finite element analysis software was used to simulate time dependent blood flow in the cephalic arch with velocity, pressure and wall shear stress profiles generated.

Results
Our models generated from imaging and flow measurements at 3 and 12 months offer snapshots of the patient’s cephalic arch at a precise time point, although the remodeling of the vessel downstream of an arteriovenous fistula in patients undergoing regular dialysis is a dynamic process that persists over long periods of time (~ 5 years). The velocity and pressure increase at the cephalic bend cause abnormal hemodynamics most prominent along the inner wall of the terminal cephalic arch. The topology of the cephalic arch is highly variable between subjects and predictive of pathologic stenosis at later time points.

Conclusions
Low flow velocity and wall pressure along the inner wall of the bend may provide possible nidus of endothelial activation that leads to stenosis and thrombosis. In addition, 3D modelling of the arch can indicate areas of stenosis that may be missed by venograms alone. Computational modeling reconstructed from 3D radiologic imaging and Doppler flow provides important insights into the hemodynamics of blood flow in arteriovenous fistula. This technique could be used in future studies to determine optimal flow to prevent endothelial damage for patients with arteriovenous fistula access.
Idees tis Sklirotitas kai tis Kalosynis: Ethnikismos, Sosialismos, Ratsismos (1897–1922) (‘Ideas of Cruelty and Kindness: Nationalism, Socialism, Racism [1897–1922]’), Pantelis Voutouris (2017)
Authors: Stamos Yannis 
Published: July 2021

Review of: Idees tis Sklirotitas kai tis Kalosynis: Ethnikismos, Sosialismos, Ratsismos (1897–1922) (‘Ideas of Cruelty and Kindness: Nationalism, Socialism, Racism [1897–1922]’), Pantelis Voutouris (2017)
Athens: Kastaniotis, 320 pp.,
ISBN 978-9-60036-272-5, p/bk, €19.08
FISIMED: una herramienta informática (L.M.S.) para la ayuda en el proceso de enseñanza - aprendizaje de la física médica
Authors: Sánchez Llorente José Miguel , Cabrero Fraile Francisco Javier , Rodríguez Conde María José , Borrajo Sánchez Javier , Juanes Méndez Juan Antonio 
Published: July 2021

Con la entrada en el Espacio Europeo de Educación superior como marco de referencia, se realiza un proceso de investigación educativo en la Facultad de Medicina de la Universidad de Salamanca (España). Se ha diseñado y codificado una herramienta informática: Learning Management System, para la ayuda en el proceso de enseñanza aprendizaje de los contenidos de la Física Médica. Dicho software multicanal, llamado Fisimed, ha sido evaluado por los estudiantes de primer curso de las licenciaturas de Medicina y Odontología. La plataforma informática realizada elimina constricciones espacio - temporales, permitiendo el seguimiento individualizado en la ganancia de conocimientos por parte de cada alumno. Facilita a alumnos y profesores una vía de comunicación (tutoría continua) para la resolución de dudas y se dispone con escalabilidad permitiendo de forma sencilla el aumento de funcionalidades.
Identificación del dominio de competencias digitales en el alumnado del grado de magisterio
Authors: Pino Juste Margarita , Soto Carballo Jorge 
Published: July 2021

Las Tecnologías de la información y comunicación (TIC) se convierten en la sociedad de la Información en un agente de cambio. En este contexto las TIC deben transformarse en herramientas pedagógicas al servicio del profesor con el fin de lograr una educación de calidad.
Conscientes de la importancia de que los profesores dominen las competencias digitales, hemos realizado un estudio sobre el dominio de las tecnologías de la información y la comunicación (TIC) que poseen los estudiantes de tercer curso de la titulación de Magisterio de la Universidad de Vigo. Para ello se han tenido en cuenta los conocimientos adquiridos, la frecuencia en la utilización de determinadas herramientas, su nivel de dominio en cuatro ámbitos de conocimiento: Alfabetización tecnológica, Instrumentos de trabajo intelectual, Tratamiento y difusión de la información y como Herramientas de comunicación. Así como sus motivaciones e intereses y los obstáculos encontrados en su desarrollo con el fin de establecer propuestas para la formación inicial.
Podemos concluir que, en general, el alumnado no tiene una formación específica sobre el funcionamiento de los ordenadores. Sobre el grado de conocimiento de las diferentes destrezas el alumno conoce las más básicas y las que utilizan habitualmente (abrir o bajar un archivo, crear o imprimir un documento, instalar un programa o enviar un e-mail). Utilizan habitualmente el correo como una herramienta de trabajo, mientras que la mensajería y las redes sociales las utilizan más en tiempos de ocio.
Sus actitudes hacia las TIC son muy positivas y sus motivaciones se centran fundamentalmente en que las tecnologías son útiles para mejorar su aprendizaje y para su futuro laboral.
Gestión de objetos de aprendizaje a través de la red, basado en el desarrollo de competencias
Authors: Morales Morgado Erla Mariela , Díaz San Millán Eduardo , García Peñalvo Francisco José 
Published: July 2021

Hoy en día existen una gran cantidad de bibliotecas virtuales y repositorios de recursos en general, donde es posible acceder a diverso tipo de información, destinado a múltiples áreas de conocimiento.
Uno de esos tipos de información corresponde a los Objetos de Aprendizaje (OAs), los cuales a través de sus metadatos pueden ser localizados y recuperados según necesidades educativas específicas de los usuarios.
Los objetivos educativos están claramente orientados al desarrollo de competencias, por tanto, es importante tener en cuenta materiales que puedan potenciarlas. Debido a la caracteristica de los OAs, como unidades independientes que puedan ser reutilizadas, se propone un modelo de diseño que oriente la creación de estos recursos según niveles de conocimiento necesarios para el desarrollo de competencias.
Para promover la búsqueda de estos recursos en base a niveles de conocimiento, se presenta una propuesta para su catalogación a través de metadatos, que considere además de los niveles de conocimiento, su clasificación por competencias.
Long-term glycemic control and factors, associated with response to pump insulin therapy in children
Authors: Laptev D. N. , Emelyanov A. O. , Medvedeva E D , Pereverzeva S. V. , Peterkova V. A. 
Published: July 2021

Background: In recent years, pump-based insulin therapy, also known as continuous subcutaneous insulin infusion (CSII), has become a common treatment for children with type 1 diabetes mellitus (T1DM). Despite the fact that, in general, children with type 1 diabetes achieve the best glycemic control indices during pump therapy, while there is a significant heterogeneity of metabolic outcomes among individual patients, many children with CSII do not reach the target level of HbA1c.Objective: To assess the level of glycemic control and factors associated by withdrawal of use, the response to treatment with prolonged use of CSII in children with type 1 diabetes.Materials and methods: The study included 458 children aged 1 to 18 years, treated to pump therapy at least 3 years before the study, the presence of the analyzed data in the register.Results: The level of HbA1c decreased by -0.7% compared with the primary endpoint, which was accompanied by an increase in the number of patients who reached the target level of HbA1c (<7.5%) from 17% to 36%. The best response was observed for patients under 6 years of age with HbA1c over 9% for pump insulin therapy, as well as in patients who regularly use additional bolus and basal functions and CGM. The main reason for stopping the use of the insulin pump is the inconvenience of using and wearing — 47.7%. Risk factors for pump abandonment: later age of start treatment on CSII and frequent episodes of severe hypoglycemia.Conclusion: According to the results of the study, it was shown that pump therapy is an effective method of insulin therapy, which allows to achieve a lower level of HbA1c compared to the initial values.
Comparative evaluation of empagliflozin, canagliflozin and sitagliptin cardioprotective properties in rats with experimental type 2 diabetes mellitus
Authors: Simanenkova A. V. , Minasian S. M. , Karonova T. L. , Vlasov T. D. , Timkina N. V. , Khalzova А. K. , Fuks O. S. , Shimshilashvili A. A. , Timofeeva V. A. , Borshchev Yu. Yu. , Galagudza M. M. 
Published: July 2021

Background: Myocardial infarction (MI) is one of the leading causes of mortality in patients with type 2 diabetes mellitus (DM), therefore it is essential to give preference to a glucose-lowering drug having optimal cardioprotective properties. A comparative study of the various sodium-glucose co-transporter inhibitors representatives’ protective effects in experimental MI was not carried out within the framework of one study.Aim: To evaluate the influence of empagliflozin (EMPA) and canagliflozin (CANA), in comparison with sitagliptin (SITA), on hemodynamic parameters and myocardial damage area in rats with diabetes type 2 model in experimental MI.Materials and methods: Type 2 DM was modelled in Wistar rats by means of 4-week high-fat diet followed by nicotinamide 230 mg/kg and streptozotocin 60 mg/kg administration. 4 weeks after DM induction the following groups were made: «DM+SITA» — treatment with SITA 50 mg/kg, «DM+EMPA» — treatment with EMPA 2 mg/kg, «DM+CANA» — treatment with CANA 25 mg/kg per os once daily for 8 weeks. Animals in «DM» group remained untreated for the following 8 weeks. Rats in control group were fed with standard chow. 16 weeks after the experiment beginning transient global myocardial ischemia was modelled in all rats. Hemodynamic parameters and myocardium necrosis area were evaluated.Results: The necrosis area was larger in «DM» group, than in control one (p=0.018). Infarction size in «DM+SITA» did not differ from that in «DM» group (62.92(41.29;75.84) and 57.26(45.51;70.08)%, р=0.554). Necrosis area in «DM+EMPA» and «DM+CANA» groups was smaller than in «DM» group (37.90(20.76;54.66)%, 46.15(29.77;50.55) vs 57.26(45.51;70.08)%, р=0.008 and р=0.009, respectively). Necrosis size did not differ between «DM+EMPA» and «DM+CANA» groups (p=0.630). Ischemic contracture in «DM+CANA» group was less prominent than under the use of all other glucose-lowering drugs. We observed increase of coronary blood flow in «DM+EMPA» group, in comparison with «DM», «DM+CANA» and «DM+SITA» groups.Conclusions: SITA does not have cardioprotective effect in ischemia-reperfusion injury in diabetic rats. EMPA and CANA have similarly prominent infarct-limiting properties. EMPA is able to increase coronary blood flow, whereas cardioprotective action of CANA is associated with ischemic contracture diminishing.
The Scientific Advisory board resolution: Implementation of intermittently scanned Continuous Glucose monitoring in clinical practice to improve glycemic control
Authors: Peterkova V. A. , Ametov A. S. , Mayorov A. Y. , Galstyan G. R. , Laptev D. N. , Chernikova N. A. 
Published: July 2021

The Scientific Advisory Board chaired by Academician of the Russian Academy of Sciences, Peterkova V.A. was held 26 of November in Moscow to discuss the possibilities of continuous glucose monitoring technology (CGM) implementation into routine clinical practice in Russia in order to improve glycemic control in patients with diabetes mellitus (DM).The main aims for Advisory board were to determine the most significant indicators and parameters for CGM to be implemented in practice from a practical point of view of LMWH, necessary for implementation in clinical practice, for different patients groups with diabetes.The following questions and topics were raised within the discussion: the importance of additional indicators beyond glycated hemoglobin (HbA1c) for glycemic control assessment in diabetes patients, CGM positioning in International and Russian clinical guidelines, the accuracy of CGM devises and approaches to its assessment, the role of education programs for diabetic patients, including trainings in correct use and data interpretation and analysis of CGM data obtained, clinical evidence analysis for CGM in randomized trials and real world evidence.
Perubahan Garis Pantai Menggunakan Citra Satelit Landsat di Pesisir Kecamatan Sayung, Kabupaten Demak
Authors: Ramadhani Yualita Prasida , Praktikto Ibnu , Suryono Chrisna Adhi 
Published: July 2021

Wilayah pesisir Kabupaten Demak yang terletak di bagian utara Pantai Jawa merupakan yang rentan terhadap perubahan garis pantai. Perubahan yang serius ini perlu dilakukan pemantauan terus menurus. Penelitian ini dilakukan untuk memperoleh informasi tentang perubahan garis pantai yang disebabkan oleh tingkat abrasi dan akresi yang terjadi di Kecamatan Sayung, Kabupaten Demak pada tahun 2013-2020. Metode penelitian ini dengan menggunakan metode deskriptif studi kasus dengan menggunakan teknologi penginderaan jauh. Metode penginderaan jauh yang digunakan untuk mengetahui perubahan garis pantai adalah dengan metode overlay (tumpang susun) garis pantai pada tahun yang berbeda dan Digital Shoreline Analysis System (DSAS). Hasil penelitian menunjukkan garis pantai Kecamatan Sayung dengan panjang pantai 20.953,59 m, telah mengalami abrasi pantai seluas 141,49 ha dan akresi sebesar 36,61 ha. Sehingga persentase tingkat abrasi sebesar 82% dan akresi sebesar 18%. Secara keseluruhan, rata-rata laju abrasi yang terjadi dalam kurun waktu periode 2013-2020 adalah sebesar 13,08 meter/tahun dan laju akresi sebesar 8,22 meter/tahun. Perubahan garis pantai yang terjadi dari tahun 2013 hingga tahun 2020 lebih banyak mengalami abrasi jika dibandingkan dengan akresi. The coastal area of Demak Regency, which is located on the northern coast of Java, is vulnerable to shoreline changes. This serious change is necessary for ongoing monitoring. This research was conducted to obtain information about coastline change in coastal Sayung District of Demak Regency in 2013 until 2020. This research method is done by using descriptive method of case study by using remote sensing technology. The remote sensing method used to determine shoreline changes is overlay method and Digital Shoreline Analysis System (DSAS) in different years. Based on the research results can be seen the rate of change of coastline length of 20.953,59 m, shoreline changes that occur in the form of abrasion of 141,49 ha and changes in the form of accretion of 36,61 ha. So that the proportion of the abrasion rate is 82% and the accretion is 18%.Overall, the average rate of abrasion that occurred in the 2013-2020 period was 13.08 meters / year and the accretion rate was 8.22 meters / year. Coastlines that occur from 2013 to 2020 more experienced abrasion process when compared to the accretion process.
Pemetaan Kesesuaian Lahan Untuk Budidaya Rumput Laut Di Perairan Pulau Poteran, Kabupaten Sumenep, Jawa Timur
Authors: Ferdiansyah Hendra Irawan , Pratikto Ibnu , Suryono Suryono 
Published: July 2021

Perairan Pulau Poteran merupakan salah satu wilayah yang berlokasi di Kabupaten Sumenep, Jawa Timur. Budidaya rumput laut di Pulau Poteran terdapat beberapa kendala dalam pengembangannya, yaitu dari sarana prasarana perikanan yang kurang memadai, keterbatasan pemahaman sumber daya manusia, modal, kelembagaan serta penentuan lokasi budidaya rumput laut. Penggunaan teknologi Sistem Informasi Geografis (SIG) di bidang kelautan dapat memberikan gagasan yang baru dalam kesesuaian lahan untuk budidaya rumput laut. Tujuan dilakukan penelitian ini adalah menganalisa lahan yang berpotensi untuk budidaya rumput laut di perairan Pulau Poteran dan mengetahui luas lahan yang efektif untuk pengembangan budidaya rumput laut di perairan Pulau Poteran. Metode penelitian yang digunakan adalah metode eksploratif dengan pendekatan analisa kuantitatif untuk mengetahui tingkatan dan luasan kesesuaian lahan budidaya rumput laut di perairan Pulau Poteran. Hasil penelitian menunjukkan bahwa luas untuk kategori sangat sesuai (S1) sebesar 7.335,59 ha, sedangkan untuk kategori sesuai (S2) memiliki luas sebesar 17.990,11 ha dan kategori tidak sesuai (S3) memiliki luas sebesar 24.665,28 ha. Luas lahan yang efektif untuk pengembangan budidaya rumput laut di perairan Pulau Poteran sebesar 4.401,35 ha (60% dari luas sangat sesuai) dengan jumlah rakit yang dioperasikan sebesar 785.955 unit dengan ukuran rakit 7 x 8 m. The territorial waters of Poteran Island are one of the areas located in Sumenep Regency, East Java. There are some problems in seaweed cultivation of Poteran Island, which are facilities, fishery infrastructure, limited human resources, financial, and institutional and the determination of the location of seaweed cultivation. The use of Geographic Information System (GIS) technology in the marine field can give new idea in land suitability for seaweed cultivation. The purpose of this research is to analyze the potential for seaweed cultivation in the waters of Poteran Island and know the effective land area for the development of seaweed cultivation in the waters of Poteran Island. The research method used is an exploratory method with a quantitative analysis approach to determine the level and extent of the suitability of seaweed cultivation in Poteran island waters. The results showed that the area for the very suitable category (S1) amounted to 7,335.59 hectare, while the corresponding category (S2) has an area of 17,990.11 hectare and the unsuitable category (S3) has an area of 24,665.28 hectare. Effective land area for the development of seaweed cultivation in the territorial waters of Poteran Island amounted to 4,401.35 hectare (60% of the area is very suitable) with the number of rafts operated by 785,955 units with a raft size of 7 x 8 m.