bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINEARLY IMPLICIT ENERGY-PRESERVING FOURIER PSEUDOSPECTRAL SCHEMES FOR THE COMPLEX MODIFIED KORTEWEG–DE VRIES EQUATION
Authors: YAN J. L. , ZHENG L. H. , ZHU L. , LU F. Q. 
Published: January 2021

AbstractWe propose two linearly implicit energy-preserving schemes for the complex modified Korteweg–de Vries equation, based on the invariant energy quadratization method. First, a new variable is introduced and a new Hamiltonian system is constructed for this equation. Then the Fourier pseudospectral method is used for the space discretization and the Crank–Nicolson leap-frog schemes for the time discretization. The proposed schemes are linearly implicit, which is only needed to solve a linear system at each time step. The fully discrete schemes can be shown to conserve both mass and energy in the discrete setting. Some numerical examples are also presented to validate the effectiveness of the proposed schemes.
FACTORIZATION LENGTH DISTRIBUTION FOR AFFINE SEMIGROUPS III: MODULAR EQUIDISTRIBUTION FOR NUMERICAL SEMIGROUPS WITH ARBITRARILY MANY GENERATORS
Authors: GARCIA STEPHAN RAMON , OMAR MOHAMED , O’NEILL CHRISTOPHER , WESLEY TIMOTHY 
Published: January 2021

AbstractFor numerical semigroups with a specified list of (not necessarily minimal) generators, we describe the asymptotic distribution of factorization lengths with respect to an arbitrary modulus. In particular, we prove that the factorization lengths are equidistributed across all congruence classes that are not trivially ruled out by modular considerations.
IS THE BRAIN A DIGITAL COMPUTER? RETHINKING A BINARY QUESTION
Authors: Erden Yasemin J. 
Published: January 2021

ABSTRACTIs the brain a digital computer? What about your own brain? This article will examine these questions, some possible answers, and what persistent disagreement on the topic might indicate. Along the way we explore the metaphor at the heart of the question and assess how observer relativity features in it. We also reflect on the role of models in scientific endeavour. By the end you should have a sense of why the question matters, what some answers to it might be, and why your preferred answer is highly pertinent to any discussion.
ALZHEIMER'S DISEASE AND RELATIONSHIPS OF VALUE
Authors: Godman Marion 
Published: January 2021

ABSTRACTIn this article, I consider my relationship with my father who developed Alzheimer's disease and criticize dominant models of social interactions and relationships. I argue that the point of a relationship is not what we exchange or achieve within it. The point is not even that we depend on others for our vital needs. The point is simply that a relationship is valuable in and of itself.
Brahms, Beethoven, and a Reassessment of the Famous Footsteps
Authors: Avins Styra 
Published: January 2021

To speak of Brahms and Beethoven in the same breath is almost a cliché: Brahms was intimately conscious of Beethoven's music from early youth. This article describes the details of his youthful involvement, the compositions he had in his repertoire as well as those other works which had a powerful effect on his development. By age 20, Brahms was frequently compared to Beethoven by people who met him or heard him play. My interest is in the way he was influenced by Beethoven and the manner in which he eventually found his own voice.The compositional history of his First Symphony provides the primary focus: its long gestation, and the alleged quote by Brahms given in Max Kalbeck's massive biography: ‘I'll never write a symphony, you have no idea what it feels like … to hear the footsteps of a giant behind one’. The reference is presumably to Beethoven, but there exists no corroborating evidence that Brahms ever said those words. They gained credence as one writer after another simply accepted Kalbeck's word. Yet substantial evidence exists that in writing his biography, Kalbeck distorted and even invented ‘facts’ when it suited his purposes, including a specific instance dealing with writing a symphony.An alternative view of the symphony's long gestation is based on a view of Brahms's compositional history. He wrote for musical forces he knew at first hand, and only from 1872 to 1875 did he have command of an orchestra. Intriguingly, while fulfilling the contemporary accepted demands of a symphony after Beethoven, Brahms devised an unusual strategy for the final movement, the basis of its great success.
European political parties’ complicity in democratic backsliding
Authors: WOLKENSTEIN FABIO 
Published: January 2021

AbstractThis article discusses the contribution of European political parties to democratic backsliding. It focuses on the European People’s Party’s efforts to protect the Hungarian government, and the European Conservatives and Reformists party’s permissive acceptance of the Polish government’s attacks on democracy and the rule of law, analysing these patterns of behaviour as a form of complicity in democratic backsliding. In a second step, the article examines the existing possibilities and normative justification for sanctioning European political parties that make a complicit contribution to democratic backsliding.
The Revival of Quantification: Reflections on Old New Histories
Authors: Ruggles Steven 
Published: January 2021

AbstractQuantitative historical analysis in the United States surged in three distinct waves. The first quantitative wave occurred as part of the “New History” that blossomed in the early twentieth century and disappeared in the 1940s and 1950s with the rise of consensus history. The second wave thrived from the 1960s to the 1980s during the ascendance of the New Economic History, the New Political History, and the New Social History, and died out during the “cultural turn” of the late twentieth century. The third wave of historical quantification—which I call the revival of quantification—emerged in the second decade of the twenty-first century and is still underway. I describe characteristics of each wave and discuss the historiographical context of the ebb and flow of quantification in history.
Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks
Authors: Amar David , Sinnott-Armstrong Nasa , Ashley Euan A. , Rivas Manuel A. 
Published: January 2021

AbstractCausal inference via Mendelian randomization requires making strong assumptions about horizontal pleiotropy, where genetic instruments are connected to the outcome not only through the exposure. Here, we present causal Graphical Analysis Using Genetics (cGAUGE), a pipeline that overcomes these limitations using instrument filters with provable properties. This is achievable by identifying conditional independencies while examining multiple traits. cGAUGE also uses ExSep (Exposure-based Separation), a novel test for the existence of causal pathways that does not require selecting instruments. In simulated data we illustrate how cGAUGE can reduce the empirical false discovery rate by up to 30%, while retaining the majority of true discoveries. On 96 complex traits from 337,198 subjects from the UK Biobank, our results cover expected causal links and many new ones that were previously suggested by correlation-based observational studies. Notably, we identify multiple risk factors for cardiovascular disease, including red blood cell distribution width.
Mixed halide perovskites for spectrally stable and high-efficiency blue light-emitting diodes
Authors: Karlsson Max , Yi Ziyue , Reichert Sebastian , Luo Xiyu , Lin Weihua , Zhang Zeyu , Bao Chunxiong , Zhang Rui , Bai Sai , Zheng Guanhaojie , Teng Pengpeng , Duan Lian , Lu Yue , Zheng Kaibo , Pullerits Tönu , Deibel Carsten , Xu Weidong , Friend Richard , Gao Feng 
Published: January 2021

AbstractBright and efficient blue emission is key to further development of metal halide perovskite light-emitting diodes. Although modifying bromide/chloride composition is straightforward to achieve blue emission, practical implementation of this strategy has been challenging due to poor colour stability and severe photoluminescence quenching. Both detrimental effects become increasingly prominent in perovskites with the high chloride content needed to produce blue emission. Here, we solve these critical challenges in mixed halide perovskites and demonstrate spectrally stable blue perovskite light-emitting diodes over a wide range of emission wavelengths from 490 to 451 nanometres. The emission colour is directly tuned by modifying the halide composition. Particularly, our blue and deep-blue light-emitting diodes based on three-dimensional perovskites show high EQE values of 11.0% and 5.5% with emission peaks at 477 and 467 nm, respectively. These achievements are enabled by a vapour-assisted crystallization technique, which largely mitigates local compositional heterogeneity and ion migration.
A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
Authors: Zhao Shuai , Tian Run , Wu Jun , Liu Shaoli , Wang Yuanning , Wen Meng , Shang Yingxu , Liu Qing , Li Yan , Guo Ying , Wang Zhaoran , Wang Ting , Zhao Yujing , Zhao Huiru , Cao Hui , Su Yu , Sun Jiashu , Jiang Qiao , Ding Baoquan 
Published: January 2021

AbstractEffective and safe hemodialysis is essential for patients with acute kidney injury and chronic renal failures. However, the development of effective anticoagulant agents with safe antidotes for use during hemodialysis has proven challenging. Here, we describe DNA origami-based assemblies that enable the inhibition of thrombin activity and thrombus formation. Two different thrombin-binding aptamers decorated DNA origami initiates protein recognition and inhibition, exhibiting enhanced anticoagulation in human plasma, fresh whole blood and a murine model. In a dialyzer-containing extracorporeal circuit that mimicked clinical hemodialysis, the origami-based aptamer nanoarray effectively prevented thrombosis formation. Oligonucleotides containing sequences complementary to the thrombin-binding aptamers can efficiently neutralize the anticoagulant effects. The nanoarray is safe and immunologically inert in healthy mice, eliciting no detectable changes in liver and kidney functions or serum cytokine concentration. This DNA origami-based nanoagent represents a promising anticoagulant platform for the hemodialysis treatment of renal diseases.
Spontaneous mutations in the single TTN gene represent high tumor mutation burden
Authors: Oh Ji-Hye , Jang Se Jin , Kim Jihun , Sohn Insuk , Lee Ji-Young , Cho Eun Jeong , Chun Sung-Min , Sung Chang Ohk 
Published: January 2021

AbstractTumor mutation burden (TMB) is an emerging biomarker, whose calculation requires targeted sequencing of many genes. We investigated if the measurement of mutation counts within a single gene is representative of TMB. Whole-exome sequencing (WES) data from the pan-cancer cohort (n = 10,224) of TCGA, and targeted sequencing (tNGS) and TTN gene sequencing from 24 colorectal cancer samples (AMC cohort) were analyzed. TTN was identified as the most frequently mutated gene within the pan-cancer cohort, and its mutation number best correlated with TMB assessed by WES (rho = 0.917, p < 2.2e-16). Colorectal cancer was one of good candidates for the application of this diagnostic model of TTN-TMB, and the correlation coefficients were 0.936 and 0.92 for TMB by WES and TMB by tNGS, respectively. Higher than expected TTN mutation frequencies observed in other FLAGS (FrequentLy mutAted GeneS) are associated with late replication time. Diagnostic accuracy for high TMB group did not differ between TTN-TMB and TMB assessed by tNGS. Classification modeling by machine learning using TTN-TMB for MSI-H diagnosis was constructed, and the diagnostic accuracy was 0.873 by area under the curve in external validation. TTN mutation was enriched in samples possessing high immunostimulatory signatures. We suggest that the mutation load within TTN represents high TMB status.
Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life
Authors: Lorgen-Ritchie Marlene , Murray Alison D. , Staff Roger , Ferguson-Smith Anne C. , Richards Marcus , Horgan Graham W. , Phillips Louise H. , Hoad Gwen , McNeil Chris , Ribeiro Antonio , Haggarty Paul 
Published: January 2021

AbstractEpigenetic imprinting is important for neurogenesis and brain function. Hippocampal volumes and brain hyperintensities in late life have been associated with early life circumstances. Epigenetic imprinting may underpin these associations. Methylation was measured at 982 sites in 13 imprinted locations in blood samples from a longitudinal cohort by bisulphite amplicon sequencing. Hippocampal volumes and hyperintensities were determined at age 64y and 72y using MRI. Hyperintensities were determined in white matter, grey matter and infratentorial regions. Permutation methods were used to adjust for multiple testing. At 64y, H19/IGF2 and NESPAS methylation predicted hippocampal volumes. PEG3 predicted hyperintensities in hippocampal grey matter, and white matter. GNASXL predicted grey matter hyperintensities. Changes with age were predicted for hippocampal volume (MEST1, KvDMR, L3MBTL, GNASXL), white matter (MEST1, PEG3) and hippocampal grey matter hyperintensities (MCTS2, GNASXL, NESPAS, L3MBTL, MCTS2, SNRPN, MEST1). Including childhood cognitive ability, years in education, or socioeconomic status as additional explanatory variables in regression analyses did not change the overall findings. Imprinting methylation in multiple genes predicts brain structures, and their change over time. These findings are potentially relevant to the development of novel tests of brain structure and function across the life-course, strategies to improve cognitive outcomes, and our understanding of early influences on brain development and function.
A field investigation of the relationship between rotating shifts, sleep, mental health and physical activity of Australian paramedics
Authors: Khan Wahaj Anwar A. , Jackson Melinda L. , Kennedy Gerard A. , Conduit Russell 
Published: January 2021

AbstractParamedics working on a rotating shift are at an increased risk of developing chronic health issues due to continuous circadian rhythm disruption. The acute effects of shift rotation and objectively measured sleep have rarely been reported in paramedics. This study investigated the relationships between a rotating shift schedule and sleep (using actigraphy), subjective reports of sleepiness, mood, stress and fatigue. Galvanic Skin Response, energy expenditure and physical activity (BodyMedia SenseWear Armband) were also recorded across the shift schedule. Paramedics were monitored for a period of eight consecutive days across pre-shift, day shift, night shift, and 2 days off. Fifteen paramedics (M age = 39.5 and SD = 10.7 years) who worked rotational shifts experienced sleep restriction during night shift compared to pre-shift, day shift and days off (p < 0.001). Night shift was also associated with higher levels of stress (p < 0.05), fatigue (p < 0.05), and sleepiness (p < 0.05). One day off was related to a return to pre-shift functioning. Such shift-related issues have a compounding negative impact on an already stressful occupation with high rates of physical and mental health issues. Therefore, there is an urgent need to investigate methods to reduce rotating shift burden on the health of paramedics. This could be through further research aimed at providing recommendations for shift work schedules with sufficient periods for sleep and recovery from stress.
The impact of injury on apparent survival of whale sharks (Rhincodon typus) in South Ari Atoll Marine Protected Area, Maldives
Authors: Harvey-Carroll Jessica , Stewart Joshua D. , Carroll Daire , Mohamed Basith , Shameel Ibrahim , Zareer Irthisham H. , Araujo Gonzalo , Rees Richard 
Published: January 2021

AbstractThe whale shark (Rhincodon typus) is an endangered species with a declining global population. The South Ari Atoll Marine Protected Area (SAMPA), Maldives, is one of few locations globally where year-long residency of individuals occurs. This SAMPA aggregation appears to consist almost exclusively of immature males. Due to its year-round residency, this local aggregation is subjected to a high degree of tourism pressure. This ecotourism contributes to the high level of interest and protection offered to whale sharks by the local community. Unfortunately, if regulations are not followed or enforced, tourism can bring with it major stressors, such as accidental injuries. We used POPAN capture-mark-recapture models and lagged identification rate analysis to assess the effect of major injuries on whale shark residency within SAMPA. Injuries may be obtained outside SAMPA. We found individuals with major injuries had a higher apparent survival in the area than those without. Lagged identification rates also demonstrated that sharks with major injuries are more likely to return to the area. We suggest that major injuries result in sharks prolonging their time in the developmental habitat. These findings have implications for individual fitness and the population viability of this endangered species. We propose targeted conservation strategies be considered to protect sharks from further injury. Based on the presented spatio-temporal distributions of sharks, and current local knowledge of sighting patterns, speed limit zones and propeller-exclusion zones should be implemented and enforced. If carried out alongside tourist education, these measures will contribute to the protection of whale sharks within SAMPA and beyond. Furthermore, our results can aid research direction, alongside regulation and enforcement development, at similar sites worldwide.
Cognitive impairment and levodopa induced dyskinesia in Parkinson’s disease: a longitudinal study from the PACOS cohort
Authors: Luca Antonina , Monastero Roberto , Baschi Roberta , Cicero Calogero Edoardo , Mostile Giovanni , Davì Marco , Restivo Vincenzo , Zappia Mario , Nicoletti Alessandra 
Published: January 2021

AbstractAim of the study was to evaluate possible associations between cognitive dysfunctions and development of Levodopa Induced Dyskinesia (LID). PD patients from the Parkinson’s disease Cognitive impairment Study cohort who underwent a baseline and follow-up neuropsychological evaluations were enrolled. Mild Cognitive Impairment (PD-MCI) was diagnosed according to MDS level II criteria. The following cognitive domains were evaluated: episodic memory, attention, executive function, visuo-spatial function and language. A domain was considered as impaired when the subject scored 2 standard deviation below normality cut-off values in at least one test for each domain. Levodopa equivalent dose, UPDRS-ME and LID were recorded at baseline and follow-up. To identify possible neuropsychological predictors associated with the probability of LID development at follow-up, Cox proportional-hazards regression model was used. Out of 139 PD patients enrolled (87 men, mean age 65.7 ± 9.4), 18 (12.9%) were dyskinetic at baseline. Out of 121 patients non-dyskinetic at baseline, 22 (18.1%) developed LID at follow-up. The impairment of the attention and executive domains strongly predicted the development of LID (HR 4.45;95%CI 1.49–13.23 and HR 3.46; 95%CI 1.26–9.48 respectively). Impairment of the attention and executive domains increased the risk of dyskinesia reflecting the alteration of common cortical network.
Prediction of dengue outbreak in Selangor Malaysia using machine learning techniques
Authors: Salim Nurul Azam Mohd , Wah Yap Bee , Reeves Caitlynn , Smith Madison , Yaacob Wan Fairos Wan , Mudin Rose Nani , Dapari Rahmat , Sapri Nik Nur Fatin Fatihah , Haque Ubydul 
Published: January 2021

AbstractDengue fever is a mosquito-borne disease that affects nearly 3.9 billion people globally. Dengue remains endemic in Malaysia since its outbreak in the 1980’s, with its highest concentration of cases in the state of Selangor. Predictors of dengue fever outbreaks could provide timely information for health officials to implement preventative actions. In this study, five districts in Selangor, Malaysia, that demonstrated the highest incidence of dengue fever from 2013 to 2017 were evaluated for the best machine learning model to predict Dengue outbreaks. Climate variables such as temperature, wind speed, humidity and rainfall were used in each model. Based on results, the SVM (linear kernel) exhibited the best prediction performance (Accuracy = 70%, Sensitivity = 14%, Specificity = 95%, Precision = 56%). However, the sensitivity for SVM (linear) for the testing sample increased up to 63.54% compared to 14.4% for imbalanced data (original data). The week-of-the-year was the most important predictor in the SVM model. This study exemplifies that machine learning has respectable potential for the prediction of dengue outbreaks. Future research should consider boosting, or using, nature inspired algorithms to develop a dengue prediction model.
Resonance and antiresonance in Raman scattering in GaSe and InSe crystals
Authors: Osiekowicz M. , Staszczuk D. , Olkowska-Pucko K. , Kipczak Ł. , Grzeszczyk M. , Zinkiewicz M. , Nogajewski K. , Kudrynskyi Z. R. , Kovalyuk Z. D. , Patané A. , Babiński A. , Molas M. R. 
Published: January 2021

AbstractThe temperature effect on the Raman scattering efficiency is investigated in $$\varepsilon$$
ε
-GaSe and $$\gamma$$
γ
-InSe crystals. We found that varying the temperature over a broad range from 5 to 350 K permits to achieve both the resonant conditions and the antiresonance behaviour in Raman scattering of the studied materials. The resonant conditions of Raman scattering are observed at about 270 K under the 1.96 eV excitation for GaSe due to the energy proximity of the optical band gap. In the case of InSe, the resonant Raman spectra are apparent at about 50 and 270 K under correspondingly the 2.41 eV and 2.54 eV excitations as a result of the energy proximity of the so-called B transition. Interestingly, the observed resonances for both materials are followed by an antiresonance behaviour noticeable at higher temperatures than the detected resonances. The significant variations of phonon-modes intensities can be explained in terms of electron-phonon coupling and quantum interference of contributions from different points of the Brillouin zone.