bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patent foramen ovale closure review: decades of research and the evolution of the evidence
Authors: Oguntade Ayodipupo S , Oguntade Mayowa Sefiu 
Published: August 2021

Abstract
Background
A quarter of the population suffers from patent foramen ovale, a form of interatrial shunt. It has been linked to cryptogenic strokes and is a common cause of paradoxical embolism.

Main text
The benefit of closing the patent foramen ovale in cryptogenic stroke patients aged 18-60 years to prevent recurrent strokes, particularly in those with large shunts or associated atrial septal aneurysms, was recently demonstrated. It is a relatively safe procedure that necessitates post-operative anticoagulation, but it has been linked to new-onset atrial fibrillation of uncertain significance. The effectiveness of patent foramen closure depends on patient selection, and prediction scores such as the Risk of Paradoxical Embolism (RoPE) score should be used. Newer closure devices, such as bioabsorbable devices like the Biostar system and ‘device-less’ devices like the Noble Stitch, are becoming more common due to their lower operative risks. The use of such devices in future trials, as well as careful case selection, could improve the acceptability of patent foramen ovale closure in the general population, removing the need for perioperative anticoagulation.

Conclusion
Individuals aged 18-60 years with cryptogenic stroke who have adverse patent foramen ovale morphology on imaging should be offered patent foramen ovale closure, preferably using the newer closure devices. More studies are needed to determine the significance of periprocedural atrial fibrillation after device closure.
The impact of COVID-19 in the attendance of patients to the otolaryngology clinic: a retrospective review
Authors: Boonpiraks Kanachai , Nawachartkosit Yanin , Setabutr Dhave 
Published: August 2021

Abstract
Background
To evaluate the impact of the COVID-19 outbreak on patient management at an Otolaryngology Head and Neck Surgery Department at a tertiary care center in Southeast Asia. This is a retrospective review. Patient load and diagnosis at the Outpatient Division of the Otolaryngology Head and Neck Surgery Department were reviewed at the height of the initial wave of the COVID-19 pandemic. Patient-specific data was then compared during the same timeframe one year prior. Patients were then grouped into an additional subspecialty subgroup based upon their diagnosis. Descriptive statistics were analyzed.

Results
A total of 819 cases were identified in 2019 during the study period. At the peak of the first wave, cases fell to 483, constituting a 41% decrease between the years (p value = 0.083). The largest decrease was in Otology cases with a drop by 53% (p value = 0.047), with the smallest decrease noted in General cases. Laryngology visits overall showed an increase in cases by 41.7%. Moreover, new visits decreased by 35.5%, with the largest decrease in new Laryngology visits and new Head and Neck Oncology cases. New visits for general issues had the smallest drop in patients, decreasing by only 21% (p value = 0.006)

Conclusions
The COVID-19 pandemic caused a significant decrease in overall cases in the Otolaryngology Head and Neck Surgery outpatient department. Thus, in anticipation of future outbreaks, interventions may be tailored according to these trends.
Long-Term Trends and Ethnoracial Inequality in U.S. Foster Care: A Research Note
Authors: Roehrkasse Alexander F. 
Published: August 2021

Abstract
This study combines and standardizes multiple sources of administrative data to calculate rates of children in foster care in the United States from 1961 to 2018, more than tripling the length of previously available time series. Results yield novel insights about historical, geographic, and ethnoracial variation in children's experience of living without parents under state supervision. National rates of children in foster care rose from 3 per 1,000 in 1963 to a peak of almost 8 per 1,000 in 1997 before declining to just under 6 per 1,000 in 2018. After stable or increasing racial inequality in the late twentieth century, disparities between Black/African American and White children began to decrease in the twenty-first century in nearly every state, closing entirely in several Southern states but remaining wide outside the South. In many Midwestern and Western states, the extreme overrepresentation of American Indian/Alaska Native children in foster care persisted or intensified.
The Changing Association Between Homeownership and the Transition to Parenthood
Authors: Tocchioni Valentina , Berrington Ann , Vignoli Daniele , Vitali Agnese 
Published: August 2021

AbstractThe literature suggests a positive link between homeownership and the transition to parenthood. However, in recent decades, couples' preference for becoming homeowners before having their first child has been undermined by rising housing unaffordability and housing uncertainty. An archetypal example is Britain, where homeownership rates among young adults have fallen substantially as a result of low wages, unemployment, reductions in the availability of mortgage credit, and rising house prices. This situation has produced a housing crisis. Using longitudinal data from the British Household Panel Survey (1991–2008) and the United Kingdom Household Longitudinal Study (2009–2016), we apply multilevel, discrete-time event-history techniques to a sample of women aged 18–42. We investigate whether and how the link between homeownership and entering parenthood has changed in Britain in recent decades. Our findings reveal that in comparison with the 1990s, the likelihood of becoming a parent has declined among homeowners, whereas childbearing rates among private renters have remained stable. Thus, owner-occupiers and private renters have become more similar in terms of their likelihood of entering parenthood. Overall, our findings question the classical micro-level assumption of a positive link between homeownership and transition to parenthood, at least among Britain's “Generation Rent.” These findings are subsequently interpreted in terms of increased housing uncertainty.
Live imaging of the Drosophila ovarian niche shows spectrosome and centrosome dynamics during asymmetric germline stem cell division
Authors: Villa-Fombuena Gema , Lobo-Pecellín María , Marín-Menguiano Miriam , Rojas-Ríos Patricia , González-Reyes Acaimo 
Published: August 2021

ABSTRACT
Drosophila female germline stem cells (GSCs) are found inside the cellular niche at the tip of the ovary. They undergo asymmetric divisions to renew the stem cell lineage and to produce sibling cystoblasts that will in turn enter differentiation. GSCs and cystoblasts contain spectrosomes, membranous structures essential for orientation of the mitotic spindle and that, particularly in GSCs, change shape depending on the cell cycle phase. Using live imaging and a fusion protein of GFP and the spectrosome component Par-1, we follow the complete spectrosome cycle throughout GSC division and quantify the relative duration of the different spectrosome shapes. We also determine that the Par-1 kinase shuttles between the spectrosome and the cytoplasm during mitosis and observe the continuous addition of new material to the GSC and cystoblast spectrosomes. Next, we use the Fly-FUCCI tool to define, in live and fixed tissues, that GSCs have a shorter G1 compared with the G2 phase. The observation of centrosomes in dividing GSCs allowed us to determine that centrosomes separate very early in G1, before centriole duplication. Furthermore, we show that the anterior centrosome associates with the spectrosome only during mitosis and that, upon mitotic spindle assembly, it translocates to the cell cortex, where it remains anchored until centrosome separation. Finally, we demonstrate that the asymmetric division of GSCs is not an intrinsic property of these cells, as the spectrosome of GSC-like cells located outside of the niche can divide symmetrically. Thus, GSCs display unique properties during division, a behaviour influenced by the surrounding niche.
A mouse model of brittle cornea syndrome caused by mutation in Zfp469
Authors: Stanton Chloe M. , Findlay Amy S. , Drake Camilla , Mustafa Mohammad Z. , Gautier Philippe , McKie Lisa , Jackson Ian J. , Vitart Veronique 
Published: August 2021

ABSTRACT
Brittle cornea syndrome (BCS) is a rare recessive condition characterised by extreme thinning of the cornea and sclera. BCS results from loss-of-function mutations in the poorly understood genes ZNF469 or PRDM5. In order to determine the function of ZNF469 and to elucidate pathogenic mechanisms, we used genome editing to recapitulate a human ZNF469 BCS mutation in the orthologous mouse gene Zfp469. Ophthalmic phenotyping showed that homozygous Zfp469 mutation causes significant central and peripheral corneal thinning arising from reduced stromal thickness. Expression of key components of the corneal stroma in primary keratocytes from Zfp469BCS/BCS mice is affected, including decreased Col1a1 and Col1a2 expression. This alters the collagen type I/collagen type V ratio and results in collagen fibrils with smaller diameter and increased fibril density in homozygous mutant corneas, correlating with decreased biomechanical strength in the cornea. Cell-derived matrices generated by primary keratocytes show reduced deposition of collagen type I, offering an in vitro model for stromal dysfunction. Work remains to determine whether modulating ZNF469 activity will have therapeutic benefit in BCS or in conditions such as keratoconus in which the cornea thins progressively.
This article has an associated First Person interview with the first author of the paper.
Augmented ustekinumab dosing is needed to achieve clinical response in patients with anti-TNF refractory pediatric Crohn’s disease: a retrospective chart review
Authors: Do Phinga , Andersen John , Patel Ashish , Semrin Gaith , Sifuentes-Dominguez Luis , Luu Phuong , Gurram Bhaskar 
Published: August 2021

Background: Ustekinumab is a monoclonal antibody that inhibits interleukins 12 and 23. It is approved for treatment of Crohn’s disease (CD) in adults; however, there is a paucity of data regarding its use in pediatric CD. We describe our experience using ustekinumab in anti-TNF refractory CD pediatric patients. Methods: We performed a retrospective chart review on pediatric patients with CD who were started on ustekinumab from January 2016 to November 2018. We collected patient’s clinical history, previous treatment history, surgeries related to CD, disease severity, as measured by abbrPCDAI, and endoscopic severity as recorded by SES-CD before and after ustekinumab. Results: We identified 10 patients with CD who were started on ustekinumab due to non-response to currently approved agents. Seven patients needed augmented maintenance dosing every 4-6 weeks to achieve clinical response or remission. Six of these seven patients had therapeutic drug monitoring during the course of treatment, with five patients showing subtherapeutic drug levels of <4.5 μg/mL while on standard maintenance dosing every 8 weeks, and four patients showing therapeutic drug levels of >4.5 μg/mL on augmented dosing interval. The remaining three patients were on standard maintenance dosing for the duration of treatment. Conclusion: In this retrospective chart review, 7 out of 10 patients with anti-TNF refractory pediatric-onset CD required augmented maintenance doses of ustekinumab to achieve clinical response or remission. A prospective study is needed to define appropriate ustekinumab dosing and interval in management of pediatric CD.
Case Report: Metachronous bilateral upper tract and bladder urothelial carcinoma: a long-term follow-up
Authors: Hamid Agus Rizal Ardy Hariandy , Nasher Fakhri Zuhdian , Saraswati Meilania , Matondang Sahat , Arif Mochtar Chaidir 
Published: August 2021

Background: Upper tract urothelial carcinoma (UTUC) is a malignant disease of the urothelial cell lining the upper urinary tract from renal calyces, pelvises, and ureter down to the ureteral orifice. Urothelial carcinoma is a multifocal malignant tumor which tends to reoccur after treatment. Radical cystectomy shows that upper tract recurrence occurs in 0.75% to 6.4% of patients. The occurrence of contralateral UTUC after nephroureterectomy is rarer with a prevalence of 0.5%. Case presentation: The case of a 43-year-old male with metachronous bilateral UTUC was reported. The patient had undergone gemcitabine-cysplatine neoadjuvant chemotherapy followed by radical cystectomy and orthotopic neobladder for urothelial carcinoma of the bladder cT2N0M0. Left hydronephrosis was discovered three months after the procedure. The patient was diagnosed with left UTUC cT4N0M0 of renal pyelum after a series of examinations. A left open radical nephroureterectomy was conducted to remove the mass followed by adjuvant chemotherapy. This was followed up with routine ultrasound and magnetic resonance imaging (MRI) every three months with a “tumor-free” period of 26 months. Meanwhile, the patient was re-admitted with fever and an increase in creatinine value of 4.3. After further workups, the patient was diagnosed with UTUC cT2N0M0 of the right renal pyelum. A kidney sparring approach with laser evaporation of the tumor was conducted followed by eight cycles of Gemcitabine intracavity antegrade per nephrostomy. After the regimen was finished, an MRI evaluation was conducted to assess treatment results, and the mass had decreased. Conclusions: This report showed a rare case of urothelial cell carcinoma recurrences. From bladder urothelial carcinoma to left UTUC and then to contralateral UTUC. It is important to evaluate the upper tract to reduce the risk of recurrence.
ESCOLA É… ESPAÇOTEMPO DE CIÊNCIA, PESQUISA, ENSINO E EXPERIÊNCIAS COMPARTILHADAS
Authors: Silva Lincoln Tavares 
Published: August 2021

Em tempos marcados pela crise mundial associada à Pandemia (COVID-19) trazemos o desafio de lidar com a Educação e com o Ensino na perspectiva que valoriza diferentes pesquisas e experiências desenvolvidas nestes campos. A ciência e sua apropriação social, associadas têm se mostrado como caminhos fundamentais no combate a ignorâncias, discriminações e exclusões de todas as ordens. Quando do lançamento deste número, nosso país havia perdido mais de 400 mil vidas. Todavia, junto à devida solidariedade que prestamos, resolvemos não sucumbir e afirmar a importância do conhecimento socialmente construído por meio da educação. Os espaçostempos educativos são aqui explicitados nos diferentes trabalhos voltados ao ensino.
Broadband Green’s function-KKR-multiple scattering method for calculations of normalized band-field solutions in magneto-optics crystals
Authors: Gao Ruoxing , Tsang Leung , Tan Shurun , Liao Tien-Hao 
Published: August 2021

We apply the broadband Green’s function-KKR-multiple scattering theory (BBGF-KKR-MST) to calculate normalized band-field solutions of magneto-optic crystals. The advantage of the method is that the matrix eigensystem equations are of low order. For the first three bands, a total of three cylindrical waves is sufficient to characterize the eigensystem and the dimension of the matrix equation is only three. Using the eigenvalue and the eigenvector, the band-field solutions and the normalizations are calculated by two methods: (i) the method of complementary plane waves and (ii) the method of higher-order cylindrical waves. The complementary plane waves satisfy the extinction theorem. The higher-order cylindrical waves method requires only 15 coefficients of cylindrical waves to represent the band fields in the entire cell. The normalizations of the band-field solutions are calculated without the need for volumetric integrations. Results are illustrated for points in the first Brillouin zone. The CPU time requirement using MATLAB is 28 ms for the first four bands of a point in the Brillouin zone.
Simulation and experimental observations of axial position control of a photonic nanojet by a dielectric cube with a metal screen
Authors: Liu Cheng-Yang , Chen Wei-Yu , Geints Yury E. , Minin Oleg V. , Minin Igor V. 
Published: August 2021

In this Letter, we report on a numerical study, fabrication, and experimental observations of photonic nanojet (PNJ) shaping by control of a tangential electric field component. Here the PNJs are generated by a single mesoscale micro-cube that is fabricated from polydimethylsiloxane, deposited on a silicon substrate and placed on thick metal screen at illuminating wavelengths of 405, 532, and 671 nm. It is shown that the length, focal length, and width of the PNJ can be significantly reduced in the presence of the metal masks along the side faces of the micro-cube. Experimental measurements of the PNJ imaging are performed by a scanning optical microscope with laser sources. Our experimental results are in reasonable agreement with simulation predictions of the finite-difference time-domain method. Due to the appearance of the metal masks, the PNJ focal length decreases 1.5 times, the PNJ decay length decreases 1.7 times, and the PNJ resolution increases 1.2 times. Such PNJs possess great potential in complex manipulation, including integrated plasmonic circuits, biosensing, and optical tweezers.
Assessment of the Chad guinea worm surveillance information system: A pivotal foundation for eradication
Authors: Karki Saugat , Weiss Adam , Dcruz Jina , Hunt Dorothy , Haigood Brandon , Ouakou Philip Tchindebet , Chop Elisabeth , Zirimwabagabo Hubert , Rubenstein Beth L. , Yerian Sarah , Roy Sharon L. , Kamb Mary L. , Guagliardo Sarah Anne J. 
Published: August 2021

Background
In the absence of a vaccine or pharmacological treatment, prevention and control of Guinea worm disease is dependent on timely identification and containment of cases to interrupt transmission. The Chad Guinea Worm Eradication Program (CGWEP) surveillance system detects and monitors Guinea worm disease in both humans and animals. Although Guinea worm cases in humans has declined, the discovery of canine infections in dogs in Chad has posed a significant challenge to eradication efforts. A foundational information system that supports the surveillance activities with modern data management practices is needed to support continued program efficacy.

Methods
We sought to assess the current CGWEP surveillance and information system to identify gaps and redundancies and propose system improvements. We reviewed documentation, consulted with subject matter experts and stakeholders, inventoried datasets to map data elements and information flow, and mapped data management processes. We used the Information Value Cycle (IVC) and Data-Information System-Context (DISC) frameworks to help understand the information generated and identify gaps.

Results
Findings from this study identified areas for improvement, including the need for consolidation of forms that capture the same demographic variables, which could be accomplished with an electronic data capture system. Further, the mental models (conceptual frameworks) IVC and DISC highlighted the need for more detailed, standardized workflows specifically related to information management.

Conclusions
Based on these findings, we proposed a four-phased roadmap for centralizing data systems and transitioning to an electronic data capture system. These included: development of a data governance plan, transition to electronic data entry and centralized data storage, transition to a relational database, and cloud-based integration. The method and outcome of this assessment could be used by other neglected tropical disease programs looking to transition to modern electronic data capture systems.
Analysis of prevalence and influencing factors of stroke in elderly hypertensive patients: Based on the screening plan for the high-risk population of stroke in Jiading District, Shanghai
Authors: Liu Jiefeng , Chen Yuqian , Jin Chunlin , Chen Duo , Gao Guangfeng , Li Fen 
Published: August 2021

Background
The purpose of this study is to investigate and analyze the prevalence and influencing factors of stroke in hypertensive patients aged 60 and above in Jiading District, Shanghai.

Methods
The population-based study included 18,724 screened people with hypertension (age ≥ 60 years, 48.7% women). From 2016 to 2019, data on demographics, potential influencing factors and health status were collected through face-to-face interviews, physical examinations, and laboratory tests. Logistic multivariate logistic regression model was used to analyze the influencing factors associated with stroke.

Results
Among the object of study from 2016 to 2019, 2,025 patients were screened for stroke, with the overall prevalence rate of 10.82% (10.41%-11.23%). Multivariate adjusted model analysis showed that dyslipidemia (OR:1.31,95%CI:1.19–1.45), lack of exercise (OR:1.91,95%CI:1.32–2.76), atrial fibrillation [OR:1.49,95%CI:1.35–1.65), family history of stroke (OR:2.18,95%CI:1.6–2.88) were the significant independent influencing factors of stroke in hypertensive patients over 60 years old. When these four factors were combined, compared with participants without any of these factors, the multi-adjusted odds ratios (95% confidence interval) of risk of stroke for persons concurrently having one, two and three or more of these factors were 1.89 (1.67–2.13), 2.15 (1.86–2.47) and 6.84 (4.90–9.55), respectively (linear trend P < 0.001); after multivariate adjustment, the family history of stroke had additive interaction with lack of exercise [RERI = 1.08(0.22–1.94), AP = 0.19(0.04–0.35), S = 1.31(1.02–1.69)], dyslipidemia [RERI = 0.87(0.41–1.33), AP = 0.23(0.08–0.38), S = 1.46(1.04–2.05)].

Conclusion
The prevalence of stroke was high in hypertensive patients aged 60 and above in Jiading District, Shanghai. Dyslipidemia, lack of exercise, atrial fibrillation and family history of stroke were significantly associated with stroke in hypertensive population. Stroke risk can be increased especially when multiple factors coexisting, and family history of stroke combined with a lack of exercise or dyslipidemia.