bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Benefit of Antiviral Agents for Hepatocellular Carcinoma Patients With Low Preoperative HBV-DNA Loads Undergoing Curative Resection: A Meta-Analysis
Authors: Liu Kai-Xuan , Hong Jian-Guo , Wu Rui , Dong Zhao-Ru , Yang Ya-Fei , Yan Yu-Chuan , Yang Chun-Cheng , Yan Lun-Jie , Yao Sheng-Yu , Li Hai-Chao , Zhi Xu-Ting , Li Tao 
Published: February 2021

Background and AimsThe clinical benefit of adjuvant antiviral therapy after curative therapy for HCC in patients with high preoperative HBV-DNA loads has been studied widely but that in patients with low preoperative HBV-DNA loads remains controversial. The purpose of this study was to determine the effect of antiviral treatment prophylaxis on HBV reactivation, overall survival (OS), and postoperative liver function in patients with low preoperative HBV-DNA levels undergoing curative resection.MethodsA meta-analysis was conducted by searching Web of Science, PubMed, Embase, and Cochrane Library until May 2020. We used REVMAN for data analysis and completed the study under the PRISMA guidelines.ResultsThree randomized trials and seven cohort studies, comprising of 1,131 individuals, were included in the meta-analysis. Antiviral treatment significantly reduced the rate of HBV reactivation after curative treatment of HCC, with a pooled risk ratio of 0.12 (95% c.i. 0.07 to 0.21; P &lt; 0.00001). The trials were consistently favorable for the antiviral group, with a pooled hazard ratio of 0.52 (95% c.i. 0.37 to 0.74; P = 0.0002) in respect of OS rate. However, by pooling the data from studies that reported ALT on the 30th day postoperatively, the result didn’t reach statistical significance (mean difference −4.38, 95% c.i. −13.83 to 5.07; P = 0.36). The I² values of the heterogeneity test for the above three comparisons are zero.ConclusionAntiviral therapy during curative resection is effective in reducing HBV reactivation and improving OS rate in HCC patients with low viral load.
Quantification of Retinal Vessel Myogenic Constriction in Response to Blood Pressure Peaks: Implications for Flicker Light-Induced Dilatation
Authors: Streese Lukas , Vaes Anja , Infanger Denis , Roth Ralf , Hanssen Henner 
Published: February 2021

Background/AimsFlicker-light induced retinal vessel dilatation (FID), a marker of microvascular endothelial function, has been shown to be blunted in sedentary cardiovascular risk patients (SR) as well as healthy physically active individuals (HA). This study aimed to quantify the retinal myogenic response to blood pressure (BP) peaks and its effects on consecutive FID for differentiation of microvascular health.MethodsTen HA and eleven SR with a previously established restriction of arteriolar FID (aFID) (&lt;2.2%) were invited in order to assess BP-induced myogenic constriction following a standardized handgrip task and a consecutive FID. BP was measured beat-to-beat.ResultsThe complete dataset of nine HA (3 female, mean age 65 years) and nine SR (5 female, mean age 61 years) individuals was analyzed. The central retinal arteriolar diameter equivalent (CRAE) was 183 ± 11 μm for HA and 176 ± 20 μm for SR. Initial baseline aFID was 1.6 ± 0.4% in HA and 1.6 ± 0.7% in SR. Systolic (p = 0.334) and diastolic (p = 0.245) BP increase following the handgrip task was in the range of 20–30% and comparable in both groups. BP increase was followed by a significantly higher arteriolar (−2.9 ± 1.3% vs. −1.3 ± 0.6%, p &lt; 0.01) myogenic constriction in HA compared to SR. Moreover, in the consecutive assessment of FID directly after the BP-induced vessel constriction, aFID (4.1 ± 2.0% vs. 1.6 ± 0.9%, p &lt; 0.01) was higher in HA compared to SR.ConclusionInitial baseline aFID was blunted in HA and SR. Retinal myogenic constriction was impaired in SR compared to HA. The consecutive aFID after BP-induced myogenic constriction recovered in HA but remained blunted in SR. Additional assessment of retinal myogenic constriction needs to be considered to improve CV risk stratification and reduce false-positive findings of endothelial dysfunction in otherwise healthy active individuals.Clinical Trial RegistrationClinicalTrials.gov: NCT03986892 (https://clinicaltrials.gov/ct2/show/NCT03986892).
Career Choice and Attractiveness of Child and Adolescent Psychiatry as a Medical Specialty: A National French Questionnaire Survey
Authors: Revet Alexis , Raynaud Jean-Philippe , Marcelli Daniel , Falissard Bruno , Catheline Nicole , Benvegnu Grégoire 
Published: February 2021

Context: The shortage of child and adolescent psychiatrists in France affects access to early interventions and mental health services and impacts therapeutic practices and prescribing trends. This study aimed to describe factors associated with choosing child and adolescent psychiatry (CAP) as a career specialty and with assessing the level of attractiveness of this discipline and its predictors.Methods: We generated a self-report questionnaire using a modified two-step Delphi approach. The survey was conducted from January 13 to February 16, 2020, and targeted French child and adolescent psychiatrists or psychiatrists, mainly working with children and/or adolescents. We used a logistic regression model to assess the factors associated with the perception of CAP as attractive. A thematic qualitative analysis of the free comments section of the questionnaire was performed.Results: Of 863 doctors contacted by email, the response rate was 77.4% (668 respondents). Two-thirds of respondents were female and had an official specialization in CAP. One-third were aged between 31 and 40 years. The main reasons for choosing to specialize in CAP were interest in working with children (64.2%), interest in psychotherapy (52.8%), and influence of an internship in CAP during medical studies (46.0%), although only one-third of respondents actually did an internship. Over half of respondents (57.3%) identified personal factors as implicated in their choice of CAP, mainly personal psychotherapy (22.2%) and personal trauma (14.4%). Although only 58.4% of respondents perceived CAP as attractive, 97.8% had no regret about their choice, and 83.5% would make the same career choice today. A positive perception by respondents' surroundings for choosing CAP at the time of the choice was associated with a perception of CAP as currently attractive by respondents (odds ratio: 1.82; 95% confidence interval: 1.27–2.60; p = 0.001).Conclusion: CAP is in crisis and faces many challenges in France, with an urgent need to redress its demographics. Many child and adolescent psychiatrists do not regret their choice and would choose the same specialty today. To increase its attractiveness, better visibility during medical school, enhanced academic recognition, and increased remuneration seem promising.
Recent Advances in the Evaluation of Serological Assays for the Diagnosis of SARS-CoV-2 Infection and COVID-19
Authors: Chiereghin Angela , Zagari Rocco Maurizio , Galli Silvia , Moroni Alessandra , Gabrielli Liliana , Venturoli Simona , Bon Isabella , Rossini Giada , Saracino Ilaria Maria , Pavoni Matteo , Lafratta Silvia , Deni Alessandro , Felici Silvia , Borghi Michele , Guerra Luca , Raumer Luigi , Lodi Vittorio , Viale Pierluigi , Attard Luciano , Lazzarotto Tiziana ,   IRCCS St. Orsola Polyclinic of Bologna COVID-19 Research Team
Published: February 2021

Introduction: Few data on the diagnostic performance of serological tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are currently available. We evaluated sensitivity and specificity of five different widely used commercial serological assays for the detection of SARS-CoV-2–specific IgG, IgM, and IgA antibodies using reverse transcriptase-PCR assay in nasopharyngeal swab as reference standard test.Methods: A total of 337 plasma samples collected in the period April–June 2020 from SARS-CoV-2 RT-PCR positive (n = 207) and negative (n = 130) subjects were investigated by one point-of-care lateral flow immunochromatographic assay (LFIA IgG and IgM, Technogenetics) and four fully automated assays: two chemiluminescence immunoassays (CLIA-iFlash IgG and IgM, Shenzhen YHLO Biotech and CLIA-LIAISON® XL IgG, DiaSorin), one electrochemiluminescence immunoassay (ECLIA-Elecsys® total predominant IgG, Roche), and one enzyme-linked immunosorbent assay (ELISA IgA, Euroimmune).Results: The overall sensitivity of all IgG serological assays was &gt;80% and the specificity was &gt;97%. The sensitivity of IgG assays was lower within 2 weeks from the onset of symptoms ranging from 70.8 to 80%. The LFIA and CLIA-iFlash IgM showed an overall low sensitivity of 47.6 and 54.6%, while the specificity was 98.5 and 96.2%, respectively. The ELISA IgA yielded a sensitivity of 84.3% and specificity of 81.7%. However, the ELISA IgA result was indeterminate in 11.7% of cases.Conclusions: IgG serological assays seem to be a reliable tool for the retrospective diagnosis of SARS-CoV-2 infection. IgM assays seem to have a low sensitivity and IgA assay is limited by a substantial rate of indeterminate results.
Economic Burden of Myocardial Infarction Combined With Dyslipidemia
Authors: Chen Pingyu , Zhang Mengran , Zhang Yan , Su Xi , Chen Jiyan , Xu Biao , Tao Jianhong , Wang Zhen , Ma Aixia , Li Hongchao 
Published: February 2021

Background: Dyslipidemia is a common comorbidity and an important risk factor for myocardial infarction (MI). This study aimed to examine the economic burden of MI combined with dyslipidemia in China.Methods: Patients who were hospitalized due to MI combined with dyslipidemia in 2016 were enrolled. Costs were measured based on electronic medical records and questionnaires. The annual costs were analyzed by conducting descriptive statistics, univariable, and multivariable analyses.Results: Data of 900 patients were analyzed, and 144 patients were dead during the follow-up. The majority of patients were aged 51–70 years (n = 563, 62.55%) and males (n = 706, 78.44%). For all-cause costs, the median annual direct medical costs, direct non-medical costs, indirect costs, and total costs were RMB 13,168 (5,212–29,369), RMB 600 (0–1,750), RMB 676 (0–1,787), RMB 15,361 (6,440–33,943), respectively; while for cardiovascular-related costs, the corresponding costs were RMB 12,233 (3,795–23,746), RMB 515 (0–1,680), RMB 587 (0–1,655), and RMB 14,223 (4,914–28,975), respectively. Lifestyle and complications significantly affected both all-cause costs and cardiovascular-related costs.Conclusions: Increasing attention should be paid to encourage healthy lifestyle, and evidence-based medicine should focus on optimal precautions and treatments for complications, to reduce the economic burden among MI patients with a comorbid dyslipidemia.
Pelatihan Pembuatan Website Pribadi Bagi Siswa SMA Negeri 1 Kota Pagar Alam
Authors: Mulim Buhori 
Published: February 2021

Siswa SMAN 1 Kota Pagaralam merupakan bagian generasi muda pagar alam yang merupakan calon pemimpin yang membangun daerah pada masa mendatang, sehingga mereka harus disiapkan dengan baik sejak pendidikan menengah, atas dasar ini maka pihak SMAN 1 Pagaralam berusaha terus memberikan softskills tambahan sehingga dengan diadakannya pengabdian oleh Civitas Akademika STTP, SMAN 1 Pagaralam dengan peserta pengabdian menyelenggarakan pelatihan pembuatan website pribadi bagi siswa SMAN 1 Kota Pagaralam untuk menambah softskil bidang Teknologi Informasi. Pelatihan menggunakan metode ceramah dan praktek secara langsung sehingga siswa memahami dengan baik seluruh materi pelatihan yang diadakan. Agar pelatihan berjalan lancar maka dilakukan pre tes dan pos tes, dari hasil pre dan pos tes ini diketahui awal pelatihan para siswa belum pernah belajar membuat website sehingga pemahamannya kurang, tetapi setelah dilakukan penjelasan dan pelatihan siswa peserta mampu memahami teknologi informasi khususnya pembuatan website.
Pelatihan Pembuatan Blog Bagi Siswa SMA Negeri 5 Pagar Alam
Authors: Anggraini Inda , Rahmadayanti Fitria 
Published: February 2021

Blogging merupakan sarana baru untuk menyebarkan dan menyampaikan informasi pada seluruh kalangan dengan menggunakan Teknologi Informasi, pelatihan pembuatan blog pada siswa SMAN 5 Kota Pagaralam menjadi hal yang sangat penting karena sebagai pendidikan menengah yang lebih banyak pelajaran umum teori menjadikan pelatihan pembuatan blog menjadi softskill tambahan yang harus dimiliki para alumni SMAN 5 Kota Pagaralam, sehingga dengan semangat berbagi ini civitas STTP melakukan pengabdian pelatihan pembuatan blog bagi siswa SMAN 5 Kota Pagaralam. Metode pelatihan menggunakan metode ceramah dan selanjutnya praktek secara langsung membuat blog pribadi siswa, pelatihan dilaksanakang dengan terlebih dahulu dilakukan pre tes untuk mengetahui pemahaman siswa peserta terhadap teknik pembuatan blog, hasilnya para siswa peserta pelatihan pembuatan blog belum pernah membuat blog, pada akhir setelah selesai pelatihan dilakukan lagi pos tes untuk mengetahui tingkat keberhasilan pelatihan pembuatan blog ini dan hasilnya siswa peserta pelatihan pembuatan blog, mampu dan berhasil membuat blog pribadi dengan didampingi narasumber.
Pelatihan Pembuatan Jaringan LAN di SMK 1 PGRI Pagar Alam
Authors: Mukti Yogi , Lesva Okta 
Published: February 2021

SMK 1 PGRI Kota Pagar Alam sebagai pendidikan kejuruan yang memberikan pelajaran spesifik bila dibanding SMAN/MA, pada SMK 1 PGRI Kota Pagar Alam salah satu peminatannya adalah jaringan komputer, dan sebagai SMKN yang ada di daerah maka sudah barang tentu sulit memenuhi kebutuhan pembelajaran dan praktek terutama pembelajaran core utamanya pada bidang jaringan, sehingga dengan menggandeng civitas akademika STTP yang melakukan pengabdian maka SMK 1 PGRI Kota Pagar Alam melakukan pelatihan pembuatan jaringan LAN, metode yang digunakan adalah seminar dilanjutkan dengan pelatihan praktek. Pada pelatihan untuk mengetahui pemahaman peserta agar pelatihan berjalan lebih efektif dilakukan uji atau tes pendahuluan hasilnya secara teoritis rata-rata semua peserta paham tentang jaringan LAN tetapi ketika diberikan alat atau praktek mereka kebingungan, pada akhir pelatihan dilakukan lagi uji untuk memahami tingkat keberhasilan pelatihan, dan hasilnya peserta pelatihan semuanya semakin baik pemahaman teori dan mampu membuat jaringan LAN dengan menggunakan berbagai topologi yang umum.
Pelatihan Pembuatan Website Pribadi Bagi Siswa SMA NU Kota Pagar Alam
Authors: Puspita Desi , Sasmita  
Published: February 2021

Siswa SMA NU Kota Pagaralam merupakan bagian generasi muda pagar alam yang merupakan calon pemimpin yang membangun daerah pada masa mendatang, sehingga mereka harus disiapkan dengan baik sejak pendidikan menengah, atas dasar ini maka pihak SMA NU Kota Pagaralam berusaha terus memberikan softskills tambahan sehingga dengan diadakannya pengabdian oleh Civitas Akademika STTP, SMA NU Koya Pagaralam dengan peserta pengabdian menyelenggarakan pelatihan pembuatan website pribadi bagi siswa SMA NU Kota Pagaralam untuk menambah softskil bidang Teknologi Informasi. Pelatihan menggunakan metode ceramah dan praktek secara langsung sehingga siswa memahami dengan baik seluruh materi pelatihan yang diadakan. Agar pelatihan berjalan lancar maka dilakukan pre tes dan pos tes, dari hasil pre dan pos tes ini diketahui awal pelatihan para siswa belum pernah belajar membuat website sehingga pemahamannya kurang, tetapi setelah dilakukan penjelasan dan pelatihan siswa peserta mampu memahami teknologi informasi khususnya pembuatan website.
Preliminary test of the radiopharmaceutical potential of PDI-Pyr radiolabeled with 131I
Authors: Demiroğlu Hasan , Topal Gokcen , Parlak Yasemin , Dinçalp Haluk , Avcıbaşı Uğur 
Published: February 2021

Objective: Cancer is a fatal disease that arises as a result of unregulated growth and spread of malignant cells. According to the reports of World Health Organization (WHO), cancer related deaths are projected to increase in the future with the value of about 13.1 million deaths by the year 2030. In order to control this danger and growing burden, new technologies and therapeutic methods for improving the life quality of cancer patients are being developed. The overall aim of this work was to design of a new anti-cancer drug.
Methods: Radiolabeling and quality control studies of PDI-Pyr were carried out by using thin layer radiochromatography. Scintigrams were obtained using a gamma camera (Infinia, GE), which was adjusted to detect g radiations of 131I.
Results: Radiolabeling yield of 131I-PDI-Pyr was obtained to be about 97%. Also, the highest uptakes of 131I-PDI-Pyr were observed in the stomach, the liver, the lung and the bladder.
Conclusion: The novel PDI-Pyr compound was successfully radiolabeled with 131I using iodogen method for the first time. The preliminary results obtained in this study have indicated that in the case of verification of selective accumulation in some stomach liver, lung and bladder cancer cells, perylene chromophore derivatives promise to be used as new anticancer agents.
Pendampingan Kegiatan Terhadap anak Hinterland Dalam Menghadapi New Normal di Masa Covid-19
Authors: Rahmi Rahmi , Pariyanto Pariyanto , Nopriyeni Nopriyeni 
Published: February 2021

Informasi yang diperoleh anak-anak hinterland mengenai protokol kesehatan masih kurang, hanya dalam bentuk informasi teori dari media sosial tanpa ada bimbingan praktek langsung dari pihak yang berwenang. Hal ini dapat dilihat dari kurangnya kesadaran anak-anak hinterland dalam menerapkan protokol kesehatan misalnya tidak menggunakan masker ketika keluar rumah, tidak menjaga jarak, anak-anak belum bisa praktek cara mencuci tangan sesuai standar kesehatan dan kurangnya kesadaran anak-anak hinterland untuk menjaga kebersihan. Sasaran pengabdian ini anak-anak usia PAUD (pendidikan Anak Usia Dini) usia SD (sekolah dasar) Rt 03 Rw 04 Kelurahan Setokok Kecamatan Bulang. Metode yang dilakukan dengan cara memberikan informasi dan praktek secara langsung dengan beberapa tahapan 1)Persiapan melakukan survei pendahuluan untuk melihat kondisi di lapangan mengenai masalah yang dihadapi masyarakat. 2) Pelaksanaan dilakukan dengan memberikan informasi dan praktek langsung kepada anak-anak hinterland dalam menghadapi new normal di masa covid 19. Pengabdian ini bertujuan untuk memberikan kesadaran kepada anak-anak hinterland akan pentingnya menjaga kesehatan diri sendiri, keluarga dan masyarakat melalui pendampingan kegiatan dalam menghadapi New normal di masa covid 19. Hasil kegiatan menunjukkan bahwa:(1) program pendampingan kegiatan anak hinterland dalam menghadapi new normal di masa covid 19, dapat dilaksanakan dan direspon dengan baik. (2) pelaksanaan program pengabdian pada masyarakat ini sangat bermanfaat bagi masyarakat sehingga dapat meningkatkan kesadaran dan kepedulian anak-anak untuk menerapkan protokol kesehatan di masa covid 19.
The Role of Triglycerides and Triglyceride/High-Density Lipoprotein Ratio as a Positive Predictive Factor in Peripheral Vascular Disease
Authors: Basavanthappa Rajendra Prasad , Mitta Nivedita , Desai Sanjay C , Ramswamy Chandrashekar Anagavalli , Vardhan J P Vivek , Gangadharan Ashwini Naveen , Anandasu Ranjith Kumar , Maruthu Pandian Adharsh Kumar , Kumar Chowdary R Hemanth 
Published: February 2021

Background:
High triglycerides (TG) and low High density Lipoproteins (HDL) are established coronary risk predctors (ratio of 3:1 being associated with definite increase in coronary risk). The TG/HDL ratio has also been established as a predictor of major cardio vascular events, insulin resistance and metabolic syndrome. However, the utility of the same in predicting worsening of peripheral vascular disease remains under-researched.

Aims and Objectives:
We aim at establishing TG/HDL ratio as a predictor of peripheral arterial disease in diabetic patients and to also explore the role of triglycerides and lipid lowering agents, in general, in modifying this risk.

Materials and Methods:
We carried out a cross sectional study enrolling Diabetes Mellitus patients with symptoms suggestive of peripheral vascular disease. We included 304 patients and analyzed their TG levels and TG/HDL ratios stratified as per age, gender and medical history. Relevant statistical analysis was carried out.

Results:
There was a difference in TG levels in men and women who developed serious peripheral vascular events with women having significantly elevated TG levels in comparison to men. The TG/HDL ratio was also found to be 8.06 in women and 7.88 in men. This was statistically significant in comparison to the control group.

Conclusion:
TG/HDL-C ratio, also known as atherogenic index, which is easily obtained by routine biochemical evaluation can be used to prognosticate incidence of peripheral arterial disease in addition to cardiovascular risk. This would serve as an easy Outpatient prognosticating and predictive factor for further assessment and patient education.
Alpha Blocker – A Better Antihypertensive Option for Postendarterectomy Hypertension
Authors: Kumar Vineeth , Ramachandran Sreekumar , Sylaja PN , Pitchai Shivanesan 
Published: February 2021

Introduction:
The immediate postoperative hemodynamic alterations occurring after carotid endarterectomy (CEA) is called postendarterectomy hypertension (PEH). PEH results in prolonged hospital admission, increased peri-operative morbidity, and mortality. The exact causes of the PEH whether it is due to carotid sinus denervation or due to the increased norepinephrine production in cerebral and peripheral circulation remain unclear.

Materials and Methods:
A prospective analysis of 62 patients who underwent CEA from 2018 to 2019 were carried out by dividing into two groups based on the technique of surgery (conventional CEA [c-CEA], n = 31; eversion CEA [e-CEA], n = 31), and the effect of four class of drugs mainly beta blockers (βBs), calcium channel blockers (CCBs), angiotensin receptor blockers (ARBs), and alpha blockers (αBs) were studied for the prevention of PEH.

Results:
72.6% of patients developed PEH irrespective of the technique of surgery (e-CEA n = 25 c-CEA n = 20;P= 0.15). The mean postoperative dose of antihypertensive drugs (Mpostoperative) were found significantly increased compared to mean preoperative dose (Mpreoperative) in all PEH patients among βB? group (Mpreoperative 18.95 mg vs. Mpostoperative 45.76 mg;P= 0.00); CCB group (preoperative Mpreoperative 6.21 mg vs. Mpostoperative 9.79 mg;P= 0.01); ARB group (Mpreoperative 14.03 mg vs. Mpostoperative 38.23 mg;P= 0.01); but those patients with preoperative αBs have well controlled BP in the postoperative period without significant change in mean dosage; αB (Mpreoperative 0.16 mg vs. Mpostoperative 3.74 mg:P= 0.27).

Conclusions:
This study indirectly showed that fluctuations of sympathetic system are happening in both e- and c-CEA irrespective of the technique of surgery. These fluctuations were better controlled in patients who had adequate sympathetic blockade preoperatively. In other words, αB can be considered a drug of choice for PEH.