bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal analysis of human humoral responses after vaccination with a live attenuated V. cholerae vaccine
Authors: Adekunle Oluwaseyi , Dretler Alexandra , Kauffman Robert C. , Cho Alice , Rouphael Nadine , Wrammert Jens 
Published: September 2021

Vibrio choleraeis a bacterial pathogen which causes the severe acute diarrheal disease cholera. Given that a symptomatic incident of cholera can lead to long term protection, a thorough understanding of the immune response to this pathogen is needed to identify parameters critical to the generation and durability of immunity. To approach this, we utilized a live attenuated cholera vaccine to model the response toV.choleraeinfection in 12 naïve subjects. We found that this live attenuated vaccine induced durable vibriocidal antibody titers that were maintained at least one year after vaccination. Similar to what we previously reported in infected patients from Bangladesh, we found that vaccination induced plasmablast responses were primarily specific to the two immunodominant antigens lipopolysaccharide (LPS) and cholera toxin (CT). Interestingly, the magnitude of the early plasmablast response at day 7 predicted the serological outcome of vaccination at day 30. However, this correlation was no longer present at later timepoints. The acute responses displayed preferential immunoglobulin isotype usage, with LPS specific cells being largely IgM or IgA producing, while cholera toxin responses were predominantly IgG. Finally, CCR9 was highly expressed on vaccine induced plasmablasts, especially on IgM and IgA producing cells, suggesting a role in migration to the gastrointestinal tract. Collectively, these findings demonstrate that the use of a live attenuated cholera vaccine is an effective tool to examine the primary and long-term immune response followingV.choleraeexposure. Additionally, it provides insight into the phenotype and specificity of the cells which likely return to and mediate immunity at the intestinal mucosa. A thorough understanding of these properties both in peripheral blood and in the intestinal mucosae will inform future vaccine development against both cholera and other mucosal pathogens.Trial Registration:NCT03251495.
Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study
Authors: Konrad Geoffrey , Leong Christine , Bolton James M. , Prior Heather J. , Paillé Michael T. , Nepon Josh , Singal Deepa , Ekuma Okechukwu , Enns Jennifer E. , Nickel Nathan C. 
Published: September 2021

Objective
Update the evidence on use of pharmacotherapy for alcohol use disorder in a Canadian population.

Methods
Using whole-population administrative data from Manitoba, Canada, we identified all residents age 12+ who were first diagnosed with alcohol use disorder between April 1, 1996 and March 31, 2015, and compared characteristics of those who filled a prescription for naltrexone, acamprosate or disulfiram at least once during that period to those who did not fill a prescription for an alcohol use disorder medication.

Results
Only 1.3% of individuals with alcohol use disorder received pharmacotherapy (62.3% of prescriptions were for naltrexone, 39.4% for acamprosate, 7.5% for disulfiram). Most prescriptions came from family physicians in urban alcohol use disorder (53.6%) and psychiatrists (22.3%). Individuals were more likely to fill a prescription for alcohol use disorder medication if they lived in an urban vs rural environment (OR 2.25; 95% CI 1.83–2.77) or had a mood/anxiety disorder diagnosis vs no diagnosis (OR 2.40, 95% CI 1.98–2.90) in the five years before being diagnosed with alcohol use disorder.

Conclusion
Despite established evidence for the effectiveness of pharmacotherapy for alcohol use disorder, these medications continue to be profoundly underutilized in Canada.
Extrafine HFA-beclomethasone-formoterol vs. nonextrafine combination of an inhaled corticosteroid and a long acting β2-agonist in patients with persistent asthma: A systematic review and meta-analysis
Authors: Liu Ting , Yang Dan , Liu Chuntao 
Published: September 2021

Objective
Airway inflammation in asthma involves not only the central airways but extends to peripheral airways. Lung deposition may be key for an appropriate treatment of asthma. We compared the clinical effects of extrafine hydrofluoroalkane (HFA)-beclomethasone-formoterol (BDP-F) versus equipotent doses of nonextrafine combination of an inhaled corticosteroid and a long acting β2-agonist (ICS-LABA) in asthma.

Methods
We identified eligible studies by a comprehensive literature search of PubMed, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL). Data analysis was performed with the Review Manager 5.3.5 software (Cochrane IMS, 2014).

Results
A total of 2326 patients with asthma from ten published randomized controlled trials (RCTs) were enrolled for analysis. Change from baseline in morning pre-dose peak expiratory flow (PEF), evening pre-dose PEF and forced expiratory volume in one second (FEV1) were detected no significant differences between extrafine HFA-BDP-F and nonextrafine ICS-LABAs (p = 0.23, p = 0.99 and p = 0.23, respectively). Extrafine HFA-BDP-F did not show any greater benefit in forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75%), the parameter concerning peripheral airways (MD 0.03L/s, p = 0.65; n = 877). There were no substantial differences between interventions in fractional exhaled nitric oxide (FeNO) levels or in its alveolar fraction. The overall analysis showed no significant benefit of extrafine HFA-BDP-F over nonextrafine ICS-LABA in improving Asthma Control Test (ACT) score (p = 0.30) or decreasing the number of puffs of rescue medication use (p = 0.16). Extrafine HFA-BDP-F did not lead to less exacerbations than nonextrafine ICS-LABA (RR 0.61, 95% CI: 0.31 to 1.20; I2 = 0; p = 0.15).

Conclusion
Enrolled RCTs of extrafine HFA-BDP-F have demonstrated no significant advantages over the equivalent combination of nonextrafine ICS-LABA in improving pulmonary function concerning central airways or peripheral airways, improving asthma symptom control or reducing exacerbation rate.
Caecal bacterial composition of broiler chickens affected by porang glucomannan
Authors: Larasati Y. N. , Harmayani E. , Widada J. , Nurliyani N. , Perdinan A. 
Published: September 2021

Glucomannan is consisted of D-glucose and D-mannose with β-1.4 linkages. Poultry had no enzyme to digest β linkage so that porang (Amorphophallus onchophyllus) glucomannan could be a prebiotic candidate. The study purposed to determine the effect of porang glucomannan on caecum bacterial composition (similarity, diversity, grouping of bacteria) using Terminal Restriction Fragment Length Polymorphisms method and performance (body weight gain, feed intake, feed conversion ratio) of broiler chickens. One hundred and eighty unsexed day old chicks (DOC) were divided into 6 treat-ments and 3 replicates (10 birds each) using completely randomized design (CRD). The treatments were P0 (basal feed), P1 (basal feed + 0.05% porang glucomannan), P2 (basal feed + 0.1% porang glu-comannan), P3 (basal feed + 0.15% porang glucomannan), KJ (basal feed + 0.1% commercial konjac glucomannan), and KM (commercial feed). The results showed that caecal bacterial composition of porang glucomannan treatment had similarity with konjac glucomannan and basal feed. Diversity index and species number of porang glucomannan treatment was higher than konjac glucomannan. Gluco-mannan prebiotics had higher Lactobacillus while the lowest Clostridium was obtained in 0.1% porang glucomannan treatment. The inclusion of glucomannan prebiotics gave no negative effect on the per-formance of broilers.
The effects of different types of bedding on the performance, skeletal and behavioral characteristics, hygienic and immunity conditions of suckling Holstein calves
Authors: Hosseini S. M. J. , Tanha T. , Maghsoodi H. 
Published: September 2021

To investigate the effects of bedding types on the performance, skeletal and behavioral characteristics, health and immunity conditions of suckling Holstein calves, an experiment was conducted in a completely randomized design using 80 Holstein calves. The calves were distributed over 5 treatments and 4 replicates (each replicate included 2 male and 2 female calves). The 5 experimental treatments werechaff, straw, bagasse, sand, or mat. The results showed that the highest feed intake was related to the sand and chaff beddings and the highest weight gain (P<0.05) was found for the chaff, straw and sandbeddings . Withers height was highest and lowest for straw and mat treatments, respectively (P<0.05). The longest standing and resting times in calf behavior (P<0.05) were found for the sand and straw treatments, respectively. In cleanness, nose, eye, and joint scorings, the highest amount of con-tamination was related (P<0.05) to the mat and sand treatments . For immunity parameters, bagasse treatment showed the highest level of eosinophils (P<0.05) compared to the other treatments. Accord-ing to the results, it can be concluded that the straw bedding has better characteristics for growth, be-havior, and health of calves compared to the other beddings.
Influence of mica mineral on flame retardancy and mechanical properties of intumescent flame retardant polypropylene composites
Authors: Kahraman Merve , Kızılcan Nilgün , Oral Mehmet Ali 
Published: September 2021

AbstractIn many plastic applications, improvement of the flame retardancy is a very significant topic. Polypropylene (PP) is used in many applications such as housing industry due to its cost performance efficiency. Enhancement of flame retardancy properties of PP is necessary in many applications. In this study, the investigation focuses on the synergistic effect of mica mineral and IFR in enhancing the flame retardancy properties of PP in order to achieve cost competitive solution, so as to provide that different/various ratios of IFR and mica mineral were added into PP to compose 30 wt% of the total mass of the polymeric compounds. The synergistic effect of mica mineral with IFR in PP was investigated by limiting oxygen index (LOI), glow wire test (GWT), UL-94 test, thermal gravimetric analyses (TGA), and mechanical tests. The results from LOI, UL 94, and GWT tests indicated that mica added to PP/IFR compound has a synergistic flame retardancy effects with the IFR system. When the content of mica was 6 wt%, LOI value of PP compound reaches to 34.9% and becomes V-0 rating (3.2 mm) in UL 94 flammability tests and compounds pass GWT tests both at 750 and 850°C.
Adoption of strategies for clean combustion of biomass in boilers
Authors: Sharma Shrutika , Sharma Mayank , Mudgal Deepa , Bhowmick Hiralal 
Published: September 2021

Abstract
Fossil fuels like coal, oil and natural gas are continuously being used for electricity generation. However, combustion of fossil fuels has raised environmental concerns which have forced the world to search for alternative sources of energy like geothermal, solar and biomass energy. Biomass is a carbon-based fuel, readily available in many parts of the world, highly volatile with less sulphur and nitrogen content, its ash possesses the property of absorbing carbon dioxide emissions, co-firing of biomass and coal increases thermal efficiency, it creates employment opportunities and provides a better way of utilization of agricultural waste. However, chlorine species from biomass combustion results in corrosion of boiler tubes at high temperature. In this review, challenges like fouling, agglomeration, gaseous emissions, emission of heavy metals, low heating value, storage and transportation problems and high temperature corrosion have been discussed, which can limit the flexibility, economy and reliability of biomass boilers. Each of these challenges has a relatively satisfactory solution except for hot corrosion, which has been addressed through several approaches with varying success and those approaches have been presented in this review. It is recommended that the implementation of the discussed remedies can surely provide efficient, economical and ecological biomass combustion.
An enhanced feedback-feedforward control scheme for process industries
Authors: Yadav Manish , Patel Hirenkumar G. 
Published: September 2021

Abstract
In this article, a unified control scheme is proposed for dead-time compensation and disturbance rejection via feedback and feedforward controller. The objectives of this work are suggested in two folds, first tuning of fractional order feedback controller via delayed Bode’s ideal transfer function instead of conventional Bode’s ideal transfer function with the benefits of dead time compensator and second feedforward controller for disturbance rejection. An existing method is utilized for comparison with the proposed scheme. To examine the efficacy of the proposed method robustness test is also carried out via sensitivity analysis. For quantifiable evaluation of the proposed scheme Integral Absolute Error (IAE) and Integral Square Error (ISE) are utilized. For the usefulness of the proposed scheme, two practical problems are demonstrated in this paper. The limpidity and instinctive appeal of the proposed scheme make it beautiful for industrial applications.
Drawing structured plasmonic field with on-chip metalens
Authors: Wang Yulong , Min Changjun , Zhang Yuquan , Feng Fu , Si Guangyuan , Li Ling , Yuan Xiaocong 
Published: September 2021

Abstract
The ability to draw a structured surface plasmon polariton (SPP) field is an important step toward many new opportunities for a broad range of nanophotonic applications. Previous methods usually require complex experimental systems or holographic optimization algorithms that limit their practical applications. Here, we propose a simple method for flexible generation of structured SPP field with on-chip plasmonic metalenses. The metalens is composed of multiple plasmonic focusing nanostructures whose focal shape and position can be independently manipulated, and through their superposition, SPP fields with specially designed patterns are obtained. Based on this method, we demonstrate several structured SPP fields including S- and W-shaped SPP focal fields and tunable SPP bottle beams. This work could provide new ideas for on-chip manipulation of optical surface waves, and contribute to applications such as on-chip photonic information processing and integrated photonic circuits.
Acoustics as Tangible Heritage: Re-embodying the Sensory Heritage in the Boundless Reign of Sight
Authors: Fırat Hasan Baran 
Published: September 2021

Abstract
This conceptual study discusses cultural and historic sounds as tangible heritage by focusing on preservation practices for both soundscape and individual sound sources besides the acoustical fingerprints of the spaces. Although the intangible cultural heritage concept has opened a new room into the sensory objects, the formal approaches to sensory heritage are still missing and ambiguous. This study dwells on why we should classify culturally significant sensory objects as tangible heritage assets in terms of heritage, sensory semiotics, and acoustics. The digitalization methods to preserve and reconstruct acoustic heritage along with their measurable and computable nature were discussed as well.
The effect of temozolomide on Hsp60 and Hsp70 expression in extracellular vesicles derived from U87MG glioma cells
Authors: Pekmez Murat , Kılcı Cansu 
Published: September 2021

Abstract

Objectives
Temozolomide (TMZ) is an effective drug for glioblastoma multiforme (GBM), but the mechanism underlying TMZ resistance is poorly understood. New evidence has revealed that the release of heat shock proteins (Hsps) derived from extracellular vesicles (EVs) play an important role in cancer progression by modulating tumor microenvironment and cellular cross-talk. This study aims to evaluate the effects of TMZ on the expression of EV-derived and cellular Hsps and cell motility in U87MG human glioblastoma cell line.

Methods
Glial-EVs were isolated from the culture medium and characterized by SEM and immunoblotting. The effect of TMZ treatments (25, 200 and 750 µM) on cell proliferation (MTT assay), migration (scratch assay), and Hsp60 and Hsp70 levels (immunoblotting) were evaluated.

Results
TMZ treatments led to an increase in intracellular Hsp70 while decreasing EV-derived Hsp70. Cellular Hsp60 level was elevated at the low dose of TMZ, but it reduced at higher TMZ concentrations. Hsp60 was also decreased in EVs secreted from TMZ-treated cells. Besides, TMZ treatment reduced the proliferation and migration of glioma cells in a dose-dependent manner.

Conclusions
Our results suggest that TMZ has the potential to target both EV-derived and cellular Hsps for GBM treatment, thus it may reduce cell motility.
Exact Beltrami flows in a spherical shell
Authors: Bogoyavlenskij Oleg 
Published: September 2021

Abstract
Exact flows of an incompressible fluid satisfying the Beltrami equation inside a spherical shell are constructed in the Cartesian coordinates in terms of elementary functions. Two scale-invariant equations defining two infinite series of eigenvalues λ

n
and

λ

̃

m

${\tilde {\lambda }}_{m}$

of the operator curl in the shell with the nonpenetration boundary conditions on the boundary spheres are derived. The corresponding eigenfields are presented in explicit form and their symmetries are investigated. Asymptotics of the eigenvalues λ

n
and

λ

̃

m

${\tilde {\lambda }}_{m}$

at n, m → ∞ are obtained.
Sintering behavior and ionic conductivity of Li1.5Al0.5Ti1.5(PO4)3 synthesized with different precursors
Authors: Davaasuren Bambar , Ma Qianli , Heiden Alexandra von der , Tietz Frank 
Published: September 2021

Abstract
Li1.5Al0.5Ti1.5(PO4)3 (LATP) powders were prepared from different NO
x
-free precursors using an aqueous-based solution-assisted solid-state reaction (SA-SSR). The sintering behavior, phase formation, microstructure and ionic conductivity of the powders were explored as a function of sintering temperature. The powders showed a relatively narrow temperature windows in which shrinkage occurred. Relative densities of 95% were reached upon heating between 900 and 960 °C. Depending on the morphological features of the primary particles, either homogeneous and intact microstructures with fine grains of about <2 µm in size or a broad grain size distribution, micro-cracks and grain cleavages were obtained, indicating the instability of the microstructure. Consequently, the ceramics with a homogeneous microstructure possessed a maximum total ionic conductivity of 0.67 mS cm−1, whereas other ceramics reached only 0.58 mS cm−1 and 0.21 mS cm−1.
Performance Differences Between Greco-Roman and Freestyle Wrestlers: A Systematic Review and Meta-Analysis
Authors: Ulupınar Süleyman , Özbay Serhat , Gençoğlu Cebrail , İnce İzzet 
Published: September 2021

Abstract
Ulupınar, S, Özbay, S, Gençoğlu, C, and İnce, İ. Performance differences between Greco-Roman and freestyle wrestlers: a systematic review and meta-analysis. J Strength Cond Res 35(11): 3270–3279, 2021—This systematic review and meta-analysis aims to summarize evidence on performance differences between Greco-Roman (GR) and freestyle (Fr) wrestlers. Eleven studies met the inclusion criteria (91 individual data and a total of 752 wrestlers). The analysis of handgrip strength comprised 9 outcomes from 5 studies with no significant difference between GR and Fr wrestlers. The analysis of isometric (back or leg) strength comprised 15 outcomes from 6 studies with a significant effect favoring GR wrestlers. The analysis of muscle power comprised 15 outcomes from 5 studies with a significant effect favoring GR wrestlers. The analysis of strength endurance comprised 4 outcomes from 3 studies with no significant difference between GR and Fr wrestlers. The analysis of anaerobic capacity and power comprised 6 outcomes from 3 studies with no significant difference between GR and Fr wrestlers. The analysis of speed comprised 19 outcomes from 7 studies with a significant effect favoring GR wrestlers. The analysis of flexibility comprised 20 outcomes from 6 studies with a significant effect favoring Fr wrestlers. This study indicated that GR wrestlers had greater isometric strength, muscle power, and speed performance, but Fr wrestlers had greater flexibility. Given the significant effect sizes favoring GR wrestlers, it is possible that they focused on training strategies to improve physical strength-power performance. However, considering the significant effect size favoring Fr wrestlers, it is possible that they focused on training strategies to improve flexibility because Fr wrestling techniques require a larger range of motion during both attack and defense.
A Novel Microcontroller-Based System for the Wheel-Running Activity in Mice
Authors: Zhu Meina , Kasaragod Deepa Kamath , Kikutani Kazuya , Taguchi Kei , Aizawa Hidenori 
Published: September 2021

AbstractVoluntary wheel-running activity is a way to assess rodents’ circadian rhythm and motivation for exercise. Deficits in these behaviors are implicated in the pathophysiology of sleep and psychiatric disorders. Limited space in animal facilities can hamper long-term monitoring of running wheel activity outside of the home cage. To address this issue, we provide a stand-alone solution to monitor the wheel-running activity of mice in their home cage. This system, named the wheel-running activity acquisition (WRAQ) system, is based on a microcontroller driven by a lithium polymer battery. With the WRAQ, we can record the wheel-running activity and illumination data for at least 30 d. Applying the WRAQ to an endotoxemia mouse model robustly detected the altered wheel-running activity and its recovery. With wireless data transfer capability extension, the system also allows for online monitoring and reporting of the circadian time (CT). We used the online monitoring of wheel-running activity with this extended WRAQ system and observed a significant shift of the active period in the circadian rhythm following a temporal chemogenetic activation of the suprachiasmatic nucleus (SCN)-subparaventricular zone (SPZ). Together, these findings indicate that the WRAQ system is a novel and cost-effective solution for the analysis of wheel-running activity in mice.