bluuebunny/crossref_metadata_2025_split huggingface dataset:
Świat duchowy Josefa Váchala w pryzmacie roku 1920
Authors: Sosnowska Danuta 
Published: January 2021

Josef Váchal’s Spiritual World Through the Prism of the Year 1920The article presents the spiritual search of one of the most original Czech artists of the 20th century. The first part of the text presents a general outline of the author’s views on the matters of God, Satan, Catholicism, the Church, Nature, Occultism, and Mysticism. The radical changes in Váchal’s worldview and the aporias of his concepts are emphasized. An important thread in this part of the text is to show the spiritual connections between Váchal’s beliefs and fears on the one hand and criticism of contemporary civilization on the other. In the second part of the article, the author’s attention was focused on one year of the artist’s life. The art and literary works produced in 1920 were created with unusual intensity and in great moral tension resulting from the fact that he had started an extramarital relationship, but this did not diminish their quality. Apart from introducing the reader to these extraordinary works, the second part of the article examines in detail Váchal’s attitude as a critic of ‘modern’ man: thoughtless and destructive towards nature, cruel towards animals. It also presents the artist’s countercultural project related to the idea of the Book as a literary labyrinth that should be traversed slowly with humility and effort, in spite of the endless rush of modern culture. Świat duchowy Josefa Váchala w pryzmacie roku 1920Artykuł prezentuje duchowe poszukiwania jednego z najbardziej oryginalnych czeskich artystów XX wieku. Materiałem interpretacyjnym są zarówno teksty literackie autora, jak i jego prace plastyczne. W pierwszej części tekstu przedstawiono ogólny zarys poglądów autora na sprawy Boga, Szatana, katolicyzmu, Kościoła, natury, okultyzmu, mistyki. Podkreślono radykalne zwroty światopoglądu Váchala, a także aporie i niekonsekwencje jego przekonań. Ważnym wątkiem w tej części tekstu jest ukazanie związków spirytualnych wierzeń i lęków Váchala z krytyką współczesnej cywilizacji. W drugiej części artykułu uwaga autora skupiła się na jednym roku z życia artysty. Powstałe w 1920 dzieła plastyczne i literackie tworzone były z niezwykłą intensywnością i w ogromnym napięciu moralnym wynikłym z nawiązania pozamałżeńskiego związku z kochanką. Nie obniżyło to ich literackiej i malarskiej jakości. Poza przybliżeniem czytelnikowi tych niezwykłych dzieł druga część artykułu poddaje szczegółowej analizie postawę Váchala jako krytyka „nowoczesnego” człowieka: bezmyślnego i destrukcyjnego wobec natury, okrutnego wobec zwierząt. Prezentuje też kontrkulturowy projekt artysty związany z ideą Księgi jako czytelniczego labiryntu, przemierzanego powoli, z pokorą i wysiłkiem, na przekór cywilizacji rządzonej przez bożka pośpiechu.
Intercomparison of MJO Column Moist Static Energy and Water Vapor Budget among Six Modern Reanalysis Products
Authors: Ren Pengfei , Kim Daehyun , Ahn Min-Seop , Kang Daehyun , Ren Hong-Li 
Published: January 2021

AbstractThis study conducts an intercomparison of the column-integrated moist static energy (MSE) and water vapor budget of the Madden–Julian oscillation (MJO) among six modern global reanalysis products (RAs). Inter-RA differences in the mean MSE, MJO MSE anomalies, individual MSE budget terms, and their relative contributions to the propagation and maintenance of MJO MSE anomalies are examined. Also investigated is the relationship between the MJO column water vapor (CWV) budget residuals with the other CWV budget terms as well as with the two parameters that characterize cloud–radiation feedback and moisture–convection coupling. Results show a noticeable inter-RA spread in the mean-state MSE, especially its vertical structure. In all RAs, horizontal MSE advection dominates the propagation of the MJO MSE while column-integrated longwave radiative heating and vertical MSE advection are found to be the key processes for MJO maintenance. The MSE budget terms directly affected by the model parameterization schemes exhibit high uncertainty. The differences in anomalous vertical velocity mainly contribute to the large differences in vertical MSE advection among the RAs. The budget residuals show large inter-RA differences and have nonnegligible contributions to MJO maintenance and propagation in most RAs. RAs that underestimate (overestimate) the strength of cloud–radiation feedback and the convective moisture adjustment time scale tend to have positive (negative) MJO CWV budget residual, indicating the critical role of these processes in the maintenance of MJO CWV anomalies. Our results emphasize that a correct representation of the interactions among moisture, convection, cloud, and radiation is the key for an accurate depiction of the MJO MSE and CWV budget in RAs.
Large Summer Rainfall Events and Their Importance in Mitigating Droughts over the South Western Cape, South Africa
Authors: De Kock W. M. , Blamey R. C. , Reason C. J. C. 
Published: January 2021

AbstractAlthough the south Western Cape receives most of its rainfall between May and September, there are substantial rainfall events in some summers. These events are of interest in themselves as well as for their possible role in mitigating the frequent winter droughts that the region suffers from. Most recently, greater Cape Town suffered a devastating drought during 2015–18 known as the Day Zero drought due to the high risk of urban areas running out of piped water supply. Estimated data from the city show that major dam levels in the south Western Cape increased more than 1% in some cases after large rainfall events (LREs) in the summer of 2018/19. This increase is significant as dam levels often decrease by several percent per month during the hot summer. In this study, LREs over the south Western Cape during the summer (October–March) are investigated together with dam level data. Most summer LREs result from atmospheric rivers (ARs) or cutoff lows (COLs). ARs have not been previously studied in the South African region except for one study for winter that showed they are responsible for almost all the heavy rainfall events in the Western Cape. Although COLs are most common in the transition months, they can also occur in midwinter and summer. COLs tend to last longer and cover larger areas than ARs, which typically yield relatively short bursts of intense rainfall mostly concentrated around greater Cape Town. After each summer LRE, average dam levels increase by up to 5%, suggesting they are very important for drought recovery. In particular, summer LREs following the anomalously dry winters of 1980, 1984, 2003, 2004, and 2015–18 played an important role in mitigating those droughts.
Surface Flux Equilibrium Estimates of Evapotranspiration at Large Spatial Scales
Authors: Chen Shiliu , McColl Kaighin A. , Berg Alexis , Huang Yuefei 
Published: January 2021

AbstractA recent theory proposes that inland continental regions are in a state of surface flux equilibrium (SFE), in which tight coupling between the land and atmosphere allow estimation of the Bowen ratio at daily to monthly time scales solely from atmospheric measurements, without calibration, even when the land surface strongly constrains the surface energy budget. However, since the theory has only been evaluated at quasi-point spatial scales using eddy covariance measurements with limited global coverage, it is unclear if it is applicable to the larger spatial scales relevant to studies of global climate. In this study, SFE estimates of the Bowen ratio are combined with satellite observations of surface net radiation to obtain large-scale estimates of latent heat flux λE. When evaluated against multiyear mean annual λE obtained from catchment water balance estimates from 221 catchments across the United States, the resulting error statistics are comparable to those in the catchment water balance estimates themselves. The theory is then used to diagnostically estimate λE using historical simulations from 26 CMIP6 models. The resulting SFE estimates are typically at least as accurate as the CMIP6 model’s simulated λE, when compared with catchment water balance estimates. Globally, there is broad spatial and temporal agreement between CMIP6 model SFE estimates and the CMIP6 model’s simulated λE, although SFE likely overestimates λE in some arid regions. We conclude that SFE applies reasonably at large spatial scales relevant to climate studies, and is broadly reproduced in climate models.
Otolaryngology Resident Wellness, Training, and Education in the Early Phase of the COVID-19 Pandemic
Authors: Chou David W. , Staltari Giuseppe , Mullen Michael , Chang Jolie , Durr Megan 
Published: January 2021

Objective: To determine changes in the residency experience early in the COVID-19 pandemic and evaluate wellness measures among otolaryngology residents. Methods: A web-based survey was administered to U.S. otolaryngology residents. Responses to the Shirom-Melamed Burnout Measure (SMBM) and the Generalized Anxiety Disorder-7 scale were recorded along with data on burnout, demographics, wellness, sleep, training, and education. Results: 119 U.S. otolaryngology residents representing 27 of 42 states with otolaryngology residency programs responded to the survey. 24.4% (95% CI 17.0-31.8%) self-reported some level of burnout, while 10.9% met SMBM criteria for “clinically relevant” burnout. 51.3% experienced more stress, and 58.8% reported more anxiety during the COVID-19 pandemic. Compared to males, females had a higher prevalence of burnout (38.9% vs 12.3%, P = .001) and anxiety (75.9% vs 43.8%, P < .001). PGY-2s had a greater mean SMBM index (3.64) and higher rates of self-reported burnout (54.2%) than their counterparts at other levels of training. Residents reported less time spent in the hospital, lower surgical volume, and less procedural independence. Educational didactics, primarily via videoconference, were more frequent for 63.9% of respondents. Conclusion: While burnout among otolaryngology residents was low early in the COVID-19 pandemic, likely due to separation from the workplace environment, trainees had higher levels of anxiety and stress. The surgical experience was negatively impacted by the pandemic, but remote didactics and educational opportunities increased. These findings may inform otolaryngology residency programs on the need to promote resident wellness and aid in devising strategies to improve the educational experience during this unique global health crisis as well as in the long term.
Gender as a Predictor of Complications in Endoscopic Sinus Surgery
Authors: Sharma Rahul K. , Dodhia Sonam , Golub Justin S. , Overdevest Jonathan B. , Gudis David A. 
Published: January 2021

Background: Understanding patient-specific risk factors for complications of functional endoscopic sinus surgery (ESS) is critical. Previous work has investigated such risk factors, but a population-based analysis has not been performed to date. Objectives: This study analyzes the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database to identify patient-specific risk factors associated with complications following ESS. Methods: A retrospective cohort study of patients who underwent ESS was conducted using the NSQIP database from 2011 to 2017. Patients were identified using CPT-codes for ESS procedures. The primary outcome analyzed was any postoperative complication. Simultaneous procedures with ESS were controlled for with regression analysis. Post-operative complications and 30-day readmission were evaluated using multivariate logistic regression controlling for age, gender, race, comorbidities (diabetes mellitus, hypertension, chronic obstructive pulmonary disease, congestive heart failure, renal failure, steroid use, and cancer history), smoking history, and intraoperative factors. Results: A total of 1279 patients who underwent ESS were identified. The average age of patients was 46.1 (SD = 16.8). Most patients (58.2%) had no major comorbidities. 594 (46.4%) patients had a tonsillectomy, adenoidectomy, or uvulopharyngoplasty at the same time as ESS. 101 (7.9%) patients experienced a complication post-operatively. 46 (3.6%) patients experienced a readmission postoperatively. The most common complication was reoperation (N = 40, 3.1%). Regression analysis revealed that gender was the only demographic factor associated with risk of post-operative complications, with women having a significantly lower risk than men (OR = 0.61, 95% CI 0.37-0.99, P = .046). Conclusions: ESS is typically performed on a relatively young and healthy population. Women have a significantly lower risk of complications after controlling for comorbidities. Further analysis of gender-specific differences in surgical outcomes should be evaluated to understand this phenomenon.
Emergency versus elective ureteroscopy for the management of ureteral stones
Authors: Gadzhiev Nariman K , Akopyan Gagik N , Tursunova Farzona I , Afyouni Andrew S , Korolev Dmitry O , Tsarichenko Dmitry G , Rapoport Leonid M , Okhunov Zhamshid , Bhaskar Somani , Malkhasyan Vigen A 
Published: January 2021

Objective: To assess the safety and efficacy of emergency ureteroscopy (URS) compared with elective URS. Methods: We conducted a retrospective analysis of patients who underwent URS for isolated ureteral stones in a single center from October 2001 to February 2014. Our patient cohort was divided into two groups: an emergency URS group (Group A), which consisted of patients who underwent URS within the first 24 h of admission, and an elective or planned URS group (Group B). The URS success rate was defined as being the incidence of successful stone fragmentation and whether there was resolution of renal obstruction. Results: A total of 2957 patients’ medical records were available for analysis. Of these, 704 (21%) comprised of emergency cases and the remaining 2253 (79%) were elective cases. Patients in Group A were younger, had a smaller BMIs, and had smaller stone sizes ( p < 0.001). The URS success rate was found to be 97% in Group A and 96% in Group B ( p = 0.35). Intraoperative or postoperative complication rates were not found to vary significantly between the groups (8% vs 7%, respectively, p = 0.50). The incidence of ureteral stenting was nearly twice as high if URS was performed during night hours (85% vs 45%, p < 0.001). However, ureteral stenting was more prevalent in Group B compared to Group A patients (57% vs 25%, p < 0.001), possibly as a result of the number of pre-stented patients (73%). Conclusions: Emergency URS is an effective and safe option for patients with renal colic. Younger patients without pre-existing obesity and with stone sizes up to 8 mm located in the distal ureter might be a better match for emergency URS.
A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome
Authors: Kamp Kendra J. , Plantinga Anna M. , Cain Kevin C. , Burr Robert L. , Barney Pamela , Jarrett Monica , Luna Ruth Ann , Savidge Tor , Shulman Robert , Heitkemper Margaret M. 
Published: January 2021

Background and Purpose: Changes in diet and lifestyle factors are frequently recommended for persons with irritable bowel syndrome (IBS). It is unknown whether these recommendations alter the gut microbiome and/or whether baseline microbiome predicts improvement in symptoms and quality of life following treatment. Therefore, the purpose of this study was to explore if baseline gut microbiome composition predicted response to a Comprehensive Self-Management (CSM) intervention and if the intervention resulted in a different gut microbiome composition compared to usual care. Methods: Individuals aged 18–70 years with IBS symptoms ≥6 months were recruited using convenience sampling. Individuals were excluded if medication use or comorbidities would influence symptoms or microbiome. Participants completed a baseline assessment and were randomized into the eight-session CSM intervention which included dietary education and cognitive behavioral therapy versus usual care. Questionnaires included demographics, quality of life, and symptom diaries. Fecal samples were collected at baseline and 3-month post-randomization for 16S rRNA-based microbiome analysis. Results: Within the CSM intervention group (n = 30), Shannon diversity, richness, and beta diversity measures at baseline did not predict benefit from the CSM intervention at 3 months, as measured by change in abdominal pain and quality of life. Based on both alpha and beta diversity, the change from baseline to follow-up microbiome bacterial taxa did not differ between CSM (n = 25) and usual care (n = 25). Conclusions and Inferences: Baseline microbiome does not predict symptom improvement with CSM intervention. We do not find evidence that the CSM intervention influences gut microbiome diversity or composition over the course of 3 months.
Checklists for Assessing Skills of Children With Type 1 Diabetes on Insulin Injection Technique
Authors: Ortiz La Banca Rebecca , Rebustini Flávio , Alvarenga Willyane A. , de Carvalho Emilia C. , Lopes Mayara , Milaszewski Kerry , Nascimento Lucila C. 
Published: January 2021

Background: School-aged children often participate in type 1 diabetes (T1D) self-care tasks. Despite widespread discussion about the importance of developing self-care skills in childhood, few explain how the health care team should assess the skills of children with T1D when performing insulin injections. Objective: We sought to assess content validity evidence in two checklists regarding injection technique performed by children. Methods: Two checklists were designed based on a systematic review of the insulin injection technique. Experts in pediatric diabetes, health literacy, and diabetes education assessed the checklists regarding their clarity, objectivity, and relevance. Content validity was assessed using the content validity ratio (CVR). Results: Eleven providers (72% nurses or physicians, professional experience 19.4 ± 10.1 years, 45% of specialists in endocrinology, and 18% in pediatrics) participated in the assessment. Experts considered items containing the word homogeneity inappropriate. Items related to the needle insertion angle and the skin fold did not reach the CVR critical value. The final version of the checklist for syringe injection comprised 22 items with CVR = 0.91, and the checklist for pen injection comprised 18 items with CVR = 0.87. Conclusions: The checklists presented clear, objective, and relevant content that assesses the skills of children with T1D for insulin injection. The checklists formally present the order of the technique and all the steps for insulin injection and allow a quantitative assessment of the operational skills of children. The developed instruments offer providers the possibility of continuous assessment of the progress of the pediatric clientele until they reach independence in diabetes self-care.
Can Cervical Cerclage Prevent Umbilical Cord Prolapse in Patients with Funic Presentation?
Authors: Petrikovsky B. , Terrani M. , Dillon A. , Sichinava L. 
Published: January 2021

Objective: Umbilical cord prolapse is a rare event complicating 0.17%–0.62% of all pregnancies. Funic presentation is a known risk factor for umbilical cord prolapse. Currently, there is no strategy to prevent umbilical cord prolapse in patients with funic presentation. The novel technique used is placement of late cervical cerclage to create a mechanical barrier and prevent an umbilical cord prolapse. Methods: Six patients with a sonographically detected funic presentation were included in the study. Funic presentation was defined as the sonographic presence of the umbilical cord below the presenting part using both transabdominal and transvaginal sonography. Cord prolapse was defined as an umbilical cord seen or palpated below the presenting part. Cervical cerclage was placed in patients with persistent funic presentations, which is the detection of the umbilical cord below the presenting part, on two or more sonograms at least a week apart. Results: Cervical cerclages were placed in six patients with funic presentation between 28 and 34 weeks of gestation without immediate complications. All patients were delivered by a cesarean section between 35 and 38 weeks of pregnancy. None experienced umbilical cord prolapse. Funic presentation was confirmed at birth in all cases. Apgar scores varied between 7 and 10. Conclusion: It appears that cervical cerclage may be an effective measure to prevent umbilical cord prolapse in cases of known persistent funic presentation.
Activated protein C has a regulatory role in factor VIII function
Authors: Wilhelm Amelia R. , Parsons Nicole A. , Samelson-Jones Benjamin J. , Davidson Robert J. , Esmon Charles T. , Camire Rodney M. , George Lindsey A. 
Published: January 2021

AbstractMechanisms thought to regulate activated factor VIII (FVIIIa) cofactor function include A2-domain dissociation and activated protein C (APC) cleavage. Unlike A2-domain dissociation, there is no known phenotype associated with altered APC cleavage of FVIII, and biochemical studies have suggested APC plays a marginal role in FVIIIa regulation. However, the in vivo contribution of FVIIIa inactivation by APC is unexplored. Here we compared wild-type B-domainless FVIII (FVIII-WT) recombinant protein with an APC-resistant FVIII variant (FVIII-R336Q/R562Q; FVIII-QQ). FVIII-QQ demonstrated expected APC resistance without other changes in procoagulant function or A2-domain dissociation. In plasma-based studies, FVIII-WT/FVIIIa-WT demonstrated dose-dependent sensitivity to APC with or without protein S, whereas FVIII-QQ/FVIIIa-QQ did not. Importantly, FVIII-QQ demonstrated approximately fivefold increased procoagulant function relative to FVIII-WT in the tail clip and ferric chloride injury models in hemophilia A (HA) mice. To minimize the contribution of FV inactivation by APC in vivo, a tail clip assay was performed in homozygous HA/FV Leiden (FVL) mice infused with FVIII-QQ or FVIII-WT in the presence or absence of monoclonal antibody 1609, an antibody that blocks murine PC/APC hemostatic function. FVIII-QQ again demonstrated enhanced hemostatic function in HA/FVL mice; however, FVIII-QQ and FVIII-WT performed analogously in the presence of the PC/APC inhibitory antibody, indicating the increased hemostatic effect of FVIII-QQ was APC specific. Our data demonstrate APC contributes to the in vivo regulation of FVIIIa, which has the potential to be exploited to develop novel HA therapeutics.