bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enriching context descriptions for enhanced LA scalability: a case study
Authors: Samuelsen Jeanette , Chen Weiqin , Wasson Barbara 
Published: March 2021

AbstractLearning analytics (LA) is a field that examines data about learners and their context, for understanding and optimizing learning and the environments in which it occurs. Integration of multiple data sources, an important dimension of scalability, has the potential to provide rich insights within LA. Using a common standard such as the Experience API (xAPI) to describe learning activity data across multiple sources can alleviate obstacles for data integration. Despite their potential, however, research indicates that standards are seldom used for integration of multiple sources in LA. Our research aims to understand and address the challenges of using current learning activity data standards for describing learning context with regard to interoperability and data integration. In this paper, we present the results of an exploratory case study involving in-depth interviews with stakeholders having used xAPI in a real-world project. Based on the subsequent thematic analysis of interviews, and examination of xAPI, we identified challenges and limitations in describing learning context data, and developed recommendations (provided in this paper in summarized form) for enriching context descriptions and enhancing the expressibility of xAPI. By situating the research in a real-world setting, our research also contributes to bridge the gap between the academic community and practitioners in learning activity data standards and scalability, focusing on description of learning context.
Debrief it all: a tool for inclusion of Safety-II
Authors: Bentley Suzanne K. , McNamara Shannon , Meguerdichian Michael , Walker Katie , Patterson Mary , Bajaj Komal 
Published: March 2021

AbstractSafety science in healthcare has historically focused primarily on reducing risk and minimizing harm by learning everything possible from when things go wrong (Safety-I). Safety-II encourages the study of all events, including the routine and mundane, not only bad outcomes. While debriefing and learning from positive events is not uncommon or new to simulation, many common debriefing strategies are more focused on Safety-I. The lack of inclusion of Safety-II misses out on the powerful analysis of everyday work.A debriefing tool highlighting Safety-II concepts was developed through expert consensus and piloting and is offered as a guide to encourage and facilitate inclusion of Safety-II analysis into debriefings. It allows for debriefing expansion from the focus on error analysis and “what went wrong” or “could have gone better” to now also capture valuable discussion of high yield Safety-II concepts such as capacities, adjustments, variation, and adaptation for successful operations in a complex system. Additionally, debriefing inclusive of Safety-II fosters increased debriefing overall by encouraging debriefing when “things go right”, not historically what is most commonly debriefed.
Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis
Authors: Pohlmeyer Christopher W. , Shang Ching , Han Pei , Cui Zhi-Hua , Jones Randall M. , Clarke Astrid S. , Murray Bernard P. , Lopez David A. , Newstrom David W. , Inzunza M. David , Matzkies Franziska G. , Currie Kevin S. , Di Paolo Julie A. 
Published: March 2021

AbstractBackgroundB cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine kinase (SYK) is a nonreceptor tyrosine kinase that mediates signaling from immunoreceptors, including the B cell receptor. Active, phosphorylated SYK has been observed in tissues from patients with SLE or cutaneous lupus erythematosus, and its inhibition is hypothesized to ameliorate disease pathogenesis. We sought to evaluate the efficacy and characterize the mechanism of action of lanraplenib, a selective oral SYK inhibitor, in the New Zealand black/white (NZB/W) murine model of SLE and LN.MethodsLanraplenib was evaluated for inhibition of primary human B cell functions in vitro. Furthermore, the effect of SYK inhibition on ameliorating LN-like disease in vivo was determined by treating NZB/W mice with lanraplenib, cyclophosphamide, or a vehicle control. Glomerulopathy and immunoglobulin G (IgG) deposition were quantified in kidneys. The concentration of proinflammatory cytokines was measured in serum. Splenocytes were analyzed by flow cytometry for B cell maturation and T cell memory maturation, and the presence of T follicular helper and dendritic cells.ResultsIn human B cells in vitro, lanraplenib inhibited B cell activating factor-mediated survival as well as activation, maturation, and immunoglobulin M production. Treatment of NZB/W mice with lanraplenib improved overall survival, prevented the development of proteinuria, and reduced blood urea nitrogen concentrations. Kidney morphology was significantly preserved by treatment with lanraplenib as measured by glomerular diameter, protein cast severity, interstitial inflammation, vasculitis, and frequency of glomerular crescents; treatment with lanraplenib reduced glomerular IgG deposition. Mice treated with lanraplenib had reduced concentrations of serum proinflammatory cytokines. Lanraplenib blocked disease-driven B cell maturation and T cell memory maturation in the spleen.ConclusionsLanraplenib blocked the progression of LN-like disease in NZB/W mice. Human in vitro and murine in vivo data suggest that lanraplenib may be efficacious in preventing disease progression in patients with LN at least in part by inhibiting B cell maturation. These data provide additional rationale for the use of lanraplenib in the treatment of SLE and LN.
Understanding the apprehension and concern haunting patients before a total knee arthroplasty
Authors: Londhe Sanjay Bhalchandra , Shah Ravi Vinod , Patwardhan Meghana , Doshi Amit Pankaj , Londhe Shubhankar Sanjay , Subhedar Kavita 
Published: March 2021

Abstract
Purpose
The aim of this prospective study was to understand the fear and apprehension factors that play on patient’s mind before total knee arthroplasty.

Methods
This retrospective cohort study included 500 consecutive patients (375 females and 125 males) who were scheduled to undergo total knee arthroplasty the next day. The patients were asked to list the most important fear in their mind regarding the operation in descending order of importance. They were given a questionnaire form which contained several capture points, including age, gender, educational background, occupation, and provision of help at home. Preoperative pain was measured by using the visual analog score, and its influence on the patients’ fear and apprehension factors was also measured.

Results
In this study, 58% of patients (50 males, 40%; 240 females, 64%) were fearful of the pain that they would experience after surgery and during the postoperative physiotherapy. The female patients showed more fear of pain than their male counterparts (P < 0.05). 18% of the patients (40 males, 32%; 50 females, 13%) listed whether they will be able to walk and perform activities of daily living after surgery as the most important fear. The male patients had more fear of returning to normal walking (P < 0.05). 20% of the patients (30 males, 24%; 70 females, 19%) were fearful about getting adequate home help after discharge from hospital (P > 0.05). 4% of patients were concerned about withstanding such a major operation. There was no difference between male and female patients (P > 0.05).

Conclusion
The majority of the patients experience apprehension of pain in the perioperative period of TKA. Preoperative counseling benefits pain management by alleviating the patient’s concerns about the fear of postoperative pain and apprehension of returning to normal walking.
Association of genetic variants with prostate cancer in Africa: a concise review
Authors: Acheampong Emmanuel , Adu Evans Asamoah , Obirikorang Christian , Amoah George , Afriyie Osei Owusu , Yorke Joseph , Anto Enoch Odame , Gyamfi Michael Adu , Acheampong Emmanuella Nsenbah , Gyasi-Sarpong Christian Kofi , Yeboah Francis Agyemang 
Published: March 2021

Abstract
Background
Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited.

Main body
In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of genome-wide association studies, linkage, and fine-mapping analyses have been conducted globally, and that explains 30–33% of PCa heritability. The African ancestry has a significant mention in PCa incidence and presentation. To date, the candidate gene approach has replicated 23 polymorphisms including dinucleotide and trinucleotide repeats in 16 genes. CYP17-rs743572, CYP3A4-rs2740574, CYP3A5-rs776746, CYP3A43-rs501275, and haplotype blocks, containing these variants, are significantly associated with PCa among some population groups but not others. With the few existing studies, the extent of genetic diversity in Africa suggests that genetic associations of PCa to African ancestry go beyond nucleotide sequence polymorphisms, to a level of environmental adaptation, which may interpret genetic risk profiles. Also, the shreds of evidence suggest that evolutionary history contributes to the high rates of PCa relative to African ancestry, and genetic associations do not always replicate across populations.

Conclusion
The genetic architecture of PCa in Africa provides important contributions to the global understanding of PCa specifically the African-ancestry hypothesis. There is a need for more prostate cancer consortiums to justify the heritable certainties of PCa among Africans, and emphasis should be placed on the genetic epidemiological model of PCa in Africa.
Post-traumatic stress symptoms among an Egyptian sample of post-remission COVID-19 survivors: prevalence and sociodemographic and clinical correlates
Authors: Abdelghani Mohamed , Hassan Mervat S. , Alsadik Maha E. , Abdelmoaty Ahmed A. , Said Amira , Atwa Samar A. 
Published: March 2021

Abstract
Background
Given its global spread, the COVID-19 virus infection itself may be experienced as a traumatic and stressful event among survivors. The post-traumatic stress symptoms (PTSS) among those surviving the disease were under evaluated. This study aimed to identify and compare PTSS and associated correlates among COVID-19 survivors and control subjects. A cross-sectional design with a convenience sampling included a total of 85 adults who survived COVID-19 virus infection and 85 control subjects (matched for age, sex, education, and socioeconomic level) who were recruited from Zagazig University Hospitals, Sharkia Province, Egypt. The participants were interviewed using a semistructured demographic and clinical checklist, Structured Clinical Interview for DSM-5 Axis I Disorders (SCID-5), the Impact of Event Scale-Revised (IES-R), and the Hospital Anxiety Depression Scale (HADS).

Results
Approximately, 72% of COVID-19 survivors experienced moderate-to-severe PTSS (compared to 53% of control subjects). Individuals who survived the COVID-19 virus infection were more likely to have intensified hyperarousal symptoms (OR: 2.7, 95% CI: 1.7–4.4), with higher total IES-R scoring (OR: 1.03, 95% CI: 1.01–1.05). Among COVID-19 survivors, those who reported moderate-to-severe PTSS were likely to experience severe COVID-19 symptoms during their illness (OR: 4.1, 95% CI: 1.4–11.9).

Conclusions
PTSS was prevalent among COVID-19 survivors in Egypt. The hyperarousal symptoms were the most experienced ones. The symptom severity of COVID-19 virus infection predicted PTSS in COVID-19 survivors.
Farmers’ knowledge and perception of finger millet blast disease and its control practices in western Kenya
Authors: Mbinda Wilton , Kavoo Agnes , Maina Fredah , Odeph Margaret , Mweu Cecilia , Nzilani Naomi , Ngugi Mathew 
Published: March 2021

Abstract
Background
Finger millet blast disease, caused by Pyricularia oryzae, is a serious constrain of finger millet production which is threatening global food security especially to the resource poor smallholder farmers in arid and semi-arid regions. The disease adversely affects finger millet production and consumption due to its wide distribution and destruction in all finger millet growing areas of southern Asia and eastern Africa. Here, we present a study that investigated the occurrence, impact, risk factors and farmers’ knowledge and perceptions of finger millet blast in Kenya.

Methods
We surveyed blast disease occurrence and interviewed farmers in Bungoma and Kisii Counties of Kenya during March–April 2019. Data were analysed using SPSS statistical program. Descriptive analysis was done by calculating means, percentages, frequencies, and standard errors. Comparative statistics, chi-square and t-tests, were used to evaluate differences existing among the farm characteristics and socio-demographics and the knowledge and perceptions of blast disease and its management practices.

Results
Our results show that blast disease is prevalent in all surveyed areas and adversely affects the productivity of the crop leading to poor yields. The disease occurrence varied from 92 to 98%, and was significantly higher in the major finger millet growing areas compared to the minor ones. Blast occurrence was associated with rainfall, altitude, planting density, intercropping and other farming practices. In all the surveyed regions, farmers had little knowledge about blast disease identification, its detection and spread. Further, the farmers’ awareness of blast disease control was inconsistent with established practices.

Conclusions
Our results show mitigation of finger millet blast disease should aim at improving farmers’ adoption of best practices through development of acceptable blast-resistant finger millet varieties, use of sustainable disease management practices, fostering linkages and creating new partnerships in the production-supply chain and maintaining a functional seed system. Findings from this study provide essential insights for effective decision making and management of the disease. This is fundamental to sustainable and secure food and income for finger millet growing farmers in Kenya.
Microplastic fibers affect dynamics and intensity of CO2 and N2O fluxes from soil differently
Authors: Rillig Matthias C. , Hoffmann Mathias , Lehmann Anika , Liang Yun , Lück Matthias , Augustin Jürgen 
Published: March 2021

AbstractMicroplastics may affect soil ecosystem functioning in critical ways, with previously documented effects including changes in soil structure and water dynamics; this suggests that microbial populations and the processes they mediate could also be affected. Given the importance for global carbon and nitrogen cycle and greenhouse warming potential, we here experimentally examined potential effects of plastic microfiber additions on CO2 and N2O greenhouse gas fluxes. We carried out a fully factorial laboratory experiment with the factors presence of microplastic fibers (0.4% w/w) and addition of urea fertilizer (100 mg N kg− 1) using one target soil. The conditions in an intensively N-fertilized arable soil were simulated by adding biogas digestate at the beginning of the incubation to all samples. We continuously monitored CO2 and N2O emissions from soil before and after urea application using a custom-built flow-through steady-state system, and we assessed soil properties, including soil structure. Microplastics affected soil properties, notably increasing soil aggregate water-stability and pneumatic conductivity, and caused changes in the dynamics and overall level of emission of both gases, but in opposite directions: overall fluxes of CO2 were increased by microplastic presence, whereas N2O emission were decreased, a pattern that was intensified following urea addition. This divergent response is explained by effects of microplastic on soil structure, with the increased air permeability likely improving O2 supply: this will have stimulated CO2 production, since mineralization benefits from better aeration. Increased O2 would at the same time have inhibited denitrification, a process contributing to N2O emissions, thus likely explaining the decrease in the latter. Our results clearly suggest that microplastic consequences for greenhouse gas emissions should become an integral part of future impact assessments, and that to understand such responses, soil structure should be assessed.
Characterization of plasma chemistry for an optimized pulse resonance atmospheric-pressure plasma system
Authors: Gulán M. , Milosavljević V. 
Published: March 2021

Abstract
The paper deals with monitoring the plasma chemistry of an atmospheric plasma low-frequency AC power supply. The study is based on optical spectroscopy and electrical measurements as diagnostic methods. The work includes details of developing and operating an in-house made, non-thermal, dielectric-free atmospheric plasma system, built for biological and agriculture applications. The experimental results clearly show the cross-dependence of the measured outputs (O3, O2, N2) and a wide range of process parameters (duty cycle, discharge frequency, voltage, etc.). A design-of-experiment approach is taken for phase-resolved optical emission spectroscopy of oxygen and nitrogen spectral lines/bands. The new plasma system allows an increase in the plasma-surface interaction selectivity and reduces plasma-induced damages to the surface.
Circuit Breakers and Biopolitical Strategies
Authors: Tan Cera Y. J. 
Published: March 2021

AbstractTaking as a starting point the challenge of containing the spread of epidemics, this article provides an oblique critique of the connections between biopolitics and contact tracing. Aligning the question of biopolitical strategies with epidemiology, the article follows the lines of continuity between containment strategies, contact-tracing technology, and circulations and networks. The uptake of mobile application surveillance by government entities to trace the spread of SARS-CoV-2 has seamlessly supplemented containment measures. Singapore's deployment of TraceTogether, an application developed by the Ministry of Health and Government Technology Agency, circumvents the use of geolocation tracking: formulating a network of infected bodies using proximity data, the population undergoes a topological change. Drawing on a tradition that acknowledges the transformative quality of technology and its implications on information societies, the article frames the enquiry within the parameters of Martin Heidegger's and Gilles Deleuze's deliberations on the ways in which technology is brought to bear on the biopolitical imaginary of a population. The technological rationality that, according to Heidegger, has gripped the entire horizon of thought is opened up for interruption wherever technology fails. In these slippages emerge spaces in which a critique of society's faults may be advanced. This article proposes a critical reading of application surveillance with a view to the biopolitical and philosophical implications of overdetermined network structures against the backdrop of contagion-related phenomena.
On the World of the Virus
Authors: Armitage John 
Published: March 2021

AbstractThis short article deals with the concept of the world, and that concept's ability to engage with the impact of the coronavirus and the remaking of image theory anew. The concept of the world can, it is argued, be utilized to offer a sustained engagement with the influence of COVID-19, particularly as the concept of the world is manifested in the work of the philosopher Martin Heidegger. To understand Heidegger's work on his most important idea of the world, this article briefly looks at image theory, at Heidegger's introduction of the notion of the gigantic, at the author's own engagement with the gigantic in the microscopic image, and finally at how we can develop and revise our appreciation of the world of the virus.
On the Beach
Authors: Beck John 
Published: March 2021

Abstract
The phrase “on the beach” originates as naval slang for being between assignments or unemployed and was used as the title for Nevil Shute's bestselling novel of 1957 about the last remaining survivors of a global nuclear conflict as they await their inevitable demise. The novel is about a certain kind of anxious passivity in the face of incomprehensible catastrophe, but it is also a narrative about work and idleness. As such, the idea of being “on the beach” invites consideration of the shore as a liminal space where often conflicting social and existential issues of meaning and purpose are played out. The waves of so-called beach shaming that occurred during the early months of the global coronavirus pandemic have located, yet again, the beach as a key battleground in contemporary cultural politics.
The clinical impact of bacterial co-infection among moderate, severe and critically ill COVID-19 patients in the second referral hospital in Surabaya
Authors: Asmarawati Tri Pudy , Rosyid Alfian Nur , Suryantoro Satriyo Dwi , Mahdi Bagus Aulia , Windradi Choirina , Wulaningrum Prastuti Asta , Arifijanto Muhammad Vitanata , Bramantono Bramantono , Triyono Erwin Astha , Rusli Musofa , Rachman Brian Eka , Marfiani Erika , Endraswari Pepy Dwi , Hadi Usman , Kuntaman Kuntaman , Nasronudin Nasronudin 
Published: March 2021

Background: Data on the prevalence of bacterial co-infections among COVID-19 patients are limited, especially in our country, Indonesia. We aimed to assess the rate of bacterial co-infections in hospitalized COVID-19 patients and report the most common microorganisms involved and the antibiotic use in these patients. Methods: This study is a retrospective cohort study, among COVID-19 adult patients admitted to Universitas Airlangga Hospital Surabaya from 14 March-30 September 2020. The bacterial infection is defined based on clinical assessment, laboratory parameters, and microbiology results. Results: A total of 218 patients with moderate to critical illness and confirmed COVID-19 were included in this study. Bacterial infection was confirmed in 43 patients (19.7%). COVID-19 patients with bacterial infections had longer hospital length of stay (17.6 ± 6.62 vs 13.31±7.12), a higher proportion of respiratory failure, intensive care treatment, and ventilator use. COVID-19 patients with bacterial infection had a worse prognosis than those without bacterial infection (p<0.04). The empirical antibiotic was given to 75.2% of the patients. Gram-negative bacteria were commonly found as causative agents in this study (n = 39; 70.37%). Conclusion: COVID-19 patients with bacterial infection have a longer length of stay and worse outcomes. Healthcare-associated infections during intensive care treatment for COVID-19 patients must be carefully prevented.