bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or REM sleep
Authors: Furman Katherine L. , Baron Lorelei , Lyons Hannah C. , Cha Timothy , Evans Jack R. , Manna Jayeeta , Zhu Limei , Mattis Joanna , Burgess Christian R. 
Published: January 2025

Regulation of food intake and energy balance is critical to survival. Hunger develops as a response to energy deficit and drives food-seeking and consumption. However, motivations to eat are varied in nature, and promoted by factors other than energy deficit. When dysregulated, non-homeostatic drives to consume can contribute to disorders of food intake, adding to the increasing prevalence of restrictive eating disorders and obesity. Melanin-concentrating hormone (MCH) neurons have been implicated in the regulation of feeding behavior, in addition to a number of other fundamental behaviors including sleep, anxiety, and maternal behavior. Several studies suggest that MCH peptide increases food consumption, while studies of MCH neurons show effects only on cued feeding, and others show no effect of MCH neuron manipulation on feeding. MCH neurons have widespread projections to diverse downstream brain regions yet few studies have investigated the function of specific projections or differentiated the behaviors they regulate. Here we use optogenetics, in combination with different behavioral paradigms, to elucidate the role of MCH projections to the nucleus accumbens (NAc) in sleep and feeding behavior. We show that MCH neurons projecting to the NAc do not induce changes in baseline feeding or REM sleep, but do enhance the preference for a food paired with optogenetic stimulation. Furthermore, this effect is diminished in female mice relative to males, in line with previous results suggesting sex differences in the functional role of MCH neurons. These results suggest that MCH projections to the NAc can enhance the rewarding value of consumed food.Significance StatementWhile feeding is often driven by hunger, there are non-homeostatic reasons why animals consume food. Melanin-concentrating hormone (MCH) neurons have been implicated in the regulation of many fundamental behaviors, including feeding, sleep and reward. They project broadly throughout the brain, suggesting that they may mediate this diverse set of behaviors independently via specific projections to downstream regions. We used optogenetic activation of MCH neurons and their projections to the nucleus accumbens (NAc) in combination with complex behavioral paradigms to demonstrate that MCH projections to the NAc do not induce baseline feeding or increases in REM sleep but do enhance the value of a paired food. These results suggest that MCH neurons contribute to non-homeostatic consumption via projections to the NAc.
EXPLORING THE MALAYSIAN CHINESE BUSINESS: A REVIEW
Authors: Ku Halim Ku Hasnan , Abdullah Mohd. Ainuddin Iskandar Lee , Haji Damin Zahrul Akmal , Yusof Yusri , Razali Jamal Rizal , Mohammad Aslam Mohd Mizan 
Published: January 2025

The paper will explore the momentum of the Chinese business in Malaysia into a consistent and competitive performance thereby making it possible to continue to lead the domestic business environment despite the many challenges before and after independence of Malaya. This paper employed the historical views conducted through literature content analysis. As a result, the study discovered that the business strategy used, particularly the maneuver capability factors in Chinese-owned companies before and after independence. Business maneuver methods were common strategies applied by the Chinese enterprises to increase the number of firm size during the period of the implementation of NEP era. The companies responded to the government’s call in opening up the ownership of shares for the Malay-Bumiputera investors without affecting their performance. Innovation to the preservation of Chinese-owned businesses in the era of NEP indicates that the companies practiced a partnership especially the small and medium enterprises and family businesses. Overall, it has proved that the dynamics of the company's business in the Chinese business based on the concept of maneuver allowed Chinese owned companies not only to survive, but to compete successfully and expand tremendously during the NEP era.
PENGGUNAAN AIR DAN LIMAU NIPIS SEBAGAI BAHAN ASAS MERAWAT PESAKIT GANGGUAN JIN: TINJAUAN PENGALAMAN PENGAMAL DALAM PERUBATAN TRADISIONAL MELAYU
Authors: Syed Omar Syed Zaidi , Mat Said Mohamad Hilmi 
Published: January 2025

This study investigates the traditional Malay medical practices involving water and lime as fundamental ingredients in treating patients believed to be afflicted by supernatural beings called Jin. The researcher is an experienced nurse specializing in Jin affliction treatment. Jin refers to creatures created by Allah from fire that can resemble angels. Nowadays, there are often reports of treatments associated with Jin disturbances in society. Unfortunately, some of these treatments don't comply with Islamic law and show signs of worrying false teachings. Therefore, the aim of this study is to identify the methods of using water and lime for Jin affliction treatment. The study's methodology is qualitative, based on the researcher's nursing experience and relevant literature review. The study's findings will explain the advantages of water and lime as treatment ingredients and the methods used in the treatment. Additionally, it will share the researcher's experiences in using these ingredients for treatment and their effectiveness with Allah's permission.
Kajian ini merupakan satu penyelidikan berkaitan cara atau kaedah perubatan tradisi orang Melayu yang menggunakan air dan juga limau nipis sebagai bahan asas dalam rangka merawat pesakit yang diganggu oleh Jin. Pengkaji adalah merupakan seorang perawat yang berpengalaman dalam bidang rawatan gangguan Jin. Jin membawa makna makhluk Allah swt yang diciptakan daripada api yang boleh menyerupai malaikat. Dewasa ini kerap kedengaran banyak kes-kes rawatan yang dikatakan mempunyai kaitan dengan gangguan Jin dalam masyarakat. Malangnya terkadang didapati rawatan yang digunakan tidak menepati kehendak syarak dan mempunyai tanda-tanda ajaran sesat yang membimbangkan. Justeru itu tujuan kajian ini dilakukan adalah untuk mengenalpasti kaedah penggunaan air dan limau nipis untuk rawatan gangguan Jin. Manakala metodologi kajian ini ialah kajian kualitatif. Ia berdasarkan kepada kajian lapangan iaitu pengalaman pengkaji sebagai seorang perawat dan kajian kepustakaan yang merujuk dokumen-dokumen yang berkaitan. Hasil dari kajian ini akan menjelaskan kelebihan air dan limau nipis yang dijadikan bahan rawatan dan kaedah yang digunakan dalam rawatan di atas. Kajian ini juga akan akan berkongsikan pengalaman pengkaji yang merawat menggunakan bahan tersebut dan keberkesanannya atas izin dari Allah.
HUBUNGAN MAQASID SYARIAH, USUL FIQH & QAWAED FIQHIYYAH DALAM PENETAPAN HUKUM FEKAH SEMASA: ANALISIS BEBERAPA PANDANGAN HUKUM DAN FATWA TERPILIH DALAM ISU-ISU HALAL
Authors: Hasanuddin Ismail , Tuan Muda Tuan Sidek 
Published: January 2025

Usul Fiqh, Qawaed Fiqhiyyah and Maqasid Shariah are three branches of knowledge which are usually associated with the process in determining a certain Islamic ruling. In relation to that, this paper is presented to discuss roles of these three branches and their relationship in the determination of contemporary Islamic rulings. There are similarities and differences among those three and often in term of application, misunderstandings arose. There is also a view that views opinions in the Syafie school are quite strict and need to be evaluated from the point of view of achieving maqasid shariah. Therefore, a relationship analysis was made on Islamic rulings in Malaysia in halal issues to see the extent to which the relationship of the three branches is implemented This study was conducted qualitatively. Data were collected and analyzed using the document analysis approach. The study found that these three branches have a close relationship particularly on Islamic rulings in halal issues in Malyasia. In fact, they complement each other. Every issued Islamic ruling must be in accordance with the principles and methods that have been outlined in those three branches. From the study, it is also noted that earlier jurists have established a well-organized methodology as a guide in the process of determination of certain Islamic law.
Tiga cabang ilmu yang biasa dihubungkan dengan penetapan hukum-hukum fekah ialah ilmu Usul Fiqh, Qawaed Fiqhiyyah dan Maqasid Syariah. Tulisan ini dikemukan bagi membincangkan hubungan antara ketiga-tiga ilmu tersebut dalam penetapan hukum fekah semasa. Terdapat persamaan dan perbezaan antara ketiga-tiganya dalam penetapan hukum fekah. Terdapat juga juga salah faham dalam aplikasi ketiga-tiganya. Di samping itu, terdapat juga kata-kata yang menyebut pendapat dalam mazhab Syafie agak ketat dan perlu dinilai kembali dari sudut pencapaian maqasid syariah. Sehubungan dengan itu, analisis hubungan juga dibuat terhadap pandangan hukum semasa di Malaysia dalam isu-isu halal untuk melihat aplikasi hubungan antara ketiga-tiga cabang ilmu ini. Kajian ini dijalankan secara kualitatif. Data-data dikumpul dan dianalisis menggunakan pendekatan analisis dokumen. Kajian mendapati bahawa ketiga-tiga disiplin ilmu ini mempunyai hubungan yang rapat antara satu sama lain serta saling melengkapi dalam penetapan hukum fekah termasuk dalam penetapan pandangan hukum dalam isu-isu halal semasa. Setiap hukum fekah yang dikeluarkan perlu selaras dengan prinsip dan kaedah yang telah digariskan oleh ketiga-tiga ilmu terbabit. Kaedah yang digunakan oleh ahli-ahli fekah terdahulu telah meninggalkan suatu tradisi yang tersusun dan kukuh sebagai panduan dalam proses pengeluaran hukum.
Phenotypic and Molecular Detection of Carbapenemase-Producing Acinetobacter baumannii Strains from Clinical Specimens in Dezful Teaching Hospital
Authors: Deihim Behnaz , Khorramizadeh Maryam 
Published: January 2025

Nowadays, antibiotic resistance in bacteria has become a global problem. Therefore, the identification of resistant strains of bacteria has attracted special attention in a pursue to choose more effective treatment solutions. One of the most common mechanisms of resistance is the production of carbapenemase enzyme in Acinetobacter baumannii. This present study aimed to detect carbapenemase-producing strains by phenotypic and molecular methods in clinical specimens collected in Ganjavian Hospital of Dezful between June 2021 and May 2022. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion and Etest assay, while the extended-spectrum beta-lactamase production (ESBLs) and Metalobetalactamases (MBLs) were detected by combined disk method using ceftazidime and ceftazidime/clavulanic acid disks and imipenem and imipenem /EDTA disks, respectively. Molecular detection of blaIMP, blaSPM, blaOXA-23, and blaOXA-24, blaOXA-58, blaGES genes was performed. Of a total of 54 strains, the highest resistance rate was for cephalosporins (98.1%), and ciprofloxacin (94.2%), in contrast to minocycline (13%). ESBL and MBL producers were 26% and 80%, respectively. All isolates had intermediate resistance against colistin. The most prevalent gene in the carbapenem-resistant A. baumannii (CRAB) was blaOXA-23, followed by blaOXA-24, blaGES, blaIMP, and blaOXA-58 genes. Present report highlights the existence of CRAB and intermediate resistance to colistin and also the co-existence of several genes from different carbapenemase classes in this region. Therefore, resistant strains should be identified promptly and specific treatment protocols should be devised to control the dissemination of resistance genes in therapeutic settings.
Presence of Children in Household Is Associated With Increased Health-Related Social Need Burden
Authors: Vest Joshua R. , Mendonca Eneida A. 
Published: January 2025

INTRODUCTION
Health-related social needs (HRSNs) are critical determinants of well-being. Children’s HRSNs are largely defined by the social status and needs of their households and caregivers. The increasing practice of HRSN screening may offer an opportunity to better assess the risks facing households with children and the risks facing pediatric patients. This study compared HRSNs between households with children and those without children.

METHODS
Adult primary care patients in Indianapolis, Indiana, completed an in-person survey between January 2022 and June 2023. The survey was comprised of instruments that measured HRSNs and identified the number of children living in their household. X2, t tests, and a series of negative binomial regressions compared the self-reported occurrence of 5 HRSNs among respondents with and without children.

RESULTS
Those with children in the household tended to be female, younger, and from racial and ethnic minority groups. The average number of HRSNs was higher for those with child in the household (1.9 vs 1.6; P = .004). Controlling for other factors, each additional child aged under 1 year increased the average number of HRSNs by 24.3% (incident rate ratio, 1.17; 95% CI, 1.03–1.33; P = .014), and with each additional child aged 1 to 4 years, the average number of HRSNs increased by 17.7% (incident rate ratio, 1.12; 95% CI, 1.01–1.25; P = .036).

CONCLUSION
These findings suggest that HRSN questionnaires completed by adults, if combined with household composition information, could be a supplementary path for health care organizations to identify the needs of pediatric patients or better understand overall needs facing their adult patients.
ANALISIS DINAMIK MODEL MATEMATIKA PENYEBARAN PENYAKIT KECANDUAN GAME ONLINE DENGAN MEMPERHATIKAN FAKTOR EDUKASI
Authors: Wigantono Sri , A'yun Qonita Qurrota , Sandariria Hardina , Dani Andrea Tri Rian , Fauziyah Meirinda 
Published: January 2025

Kecanduan bermain game online adalah bentuk penggunaan aplikasi permainan yang kurang bijak. Dampak buruk dan banyak masalah sosial muncul akibat dari kecanduan bermain game online. Pada penelitian ini dibahas model matematika penyebaran penyakit kecanduan bermain game online dengan memperhatikan faktor edukasi. Model ini bertipe SEAR yang terdiri atas empat kompartemen, yaitu Susceptible (rentan), Exposed (terpapar), Addicted (kecanduan), dan Recovered (sembuh). Kemudian, pada penelitian ini ditentukan titik setimbang, bilangan reproduksi dasar, dan dilakukan analisis kestabilan titik setimbang yang sudah diperoleh. Berdasarkan hasil analisis kestabilan titik setimbang, didapat bahwa titik setimbang bebas penyakit model bersifat stabil asimtotis jika bilangan reproduksi dasar bernilai kurang dari satu dan titik setimbang endemik bersifat stabil asimtotis jika bilangan reproduksi dasar bernilai lebih dari satu. Berdasarkan hasil simulasi numerik didapat bahwa ilustrasi kestabilan lokal titik setimbang sesuai dengan hasil analisis yaitu konvergen ke titik setimbangnya. Selain itu, dari hasil numerik juga menunjukkan keefektivitasan faktor edukasi pada model yaitu semakin tinggi tingkat edukasi, maka akan menurunkan populasi yang terpapar dan populasi kecanduan bermain game online.
OPTIMASI PRODUKSI CRUDE PALM OIL (CPO) DAN PALM KERNEL MENGGUNAKAN METODE GOAL PROGRAMMING PADA PKS PTPN 3 KEBUN TORGAMBA
Authors: Safitri Elfira , Lestari Winda Ayu 
Published: January 2025

Artikel ini membahas tentang produksi Crude Palm Oil (CPO)dan Palm Kernel. Permasalahan yang sering terjadi di perusahaan adalah belum optimalnya hasil produksi Crude Palm Oil (CPO) dan Palm Kernel. Salah satu yang terjadi pada Pabrik Kelapa Sawit (PKS) PTPN 3 Kebun Torgamba. Untuk pengambilan keputusan perusahaan dihadapkan dengan beberapa tujuan yaitu memaksimumkan target produksi CPO, memaksimumkan target produksi kernel, memaksimumkan pengolahan Tandan Buah Segar (TBS) menjadi Crude Palm Oil (CPO) dan memaksimumkan pengolahan Tandan Buah Segar (TBS) menjadi Palm Kernel. Adapun tujuan dari penelitian adalah untuk mengetahui optimasi hasil produksi Crude Palm Oil (CPO) dan Palm Kernel pada PKS PTPN 3 Kebun Torgamba menggunakan metode Goal Prorgamming. Adapun metode yang digunakan pada penelitian ini yaitu metode Goal Programming dengan pengolahan data dengan bantuan Sotware LINGO. Berdasarkan hasil penelitian diperoleh hasil produksi Crude Palm Oil (CPO) bulan Januari sampai Desember masing-masing sebesar X1Jan = 3339,894; X1Feb = 2855,776; X1Mar = 3109,063; X1Apr = 3956,287; X1Mei = 4067,840; X1Jun = 3855,665; X1Jul = 4732,602; X1Agus = 4736,529; X1Sept = 5809,200; X1Okt = 3706,200; X1Nov = 4656,870; X1Des = 4580,423. Sedangkan hasil produksi Kernel bulan Januari sampai Desember masing-masing sebesar X2Jan = 544,400; X2Feb = 419,558; X2Mar = 440,913; X2Apr = 599,437; X2Mei = 629,507; X2Jun = 591,096; X2Jul = 4732,602; X2Agus = 781,507; X2Sept = 973,041; X2Okt = 654,762; X2Nov = 862,310; X2Des = 863,782.
Difference of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio in Patients with Non-Hodgkin and Hodgkin Lymphoma
Authors: Jones Frenky , Merciana Lusi , Oehadian Amaylia , Marthoenis Marthoenis 
Published: January 2025

Background: Malignancy and inflammation are strongly connected. The inflammatory processes play a significant part in the development of lymphoma. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) can be used as potential biomarkers of inflammation in lymphoma. This study aimed to discover the differences between NLR, MLR, and PLR in patients diagnosed with non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL). Methods: This study employed a retrospective design using data from the lymphoma registry at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia from 2020 to 2023. Sampling was carried out consecutively. Hematological data of patients with NHL and HL before chemotherapy were collected. The variance between the two groups was examined utilizing the Mann-Whitney U test.Results: In total, 122 data of patients were included, consisting of 75% NHL patients and 25% HL patients with a median age of 54 years (IQR 43–62). The overall NLR, MLR, and PLR tended to be lower in nHL than in HL patients although the differences were not statistically significant; with NLR 2.7 (0.7 – 12.2) vs. 3.2 (1.1 – 10.8) p=0.287, MLR 0.36 (0.04 – 1.86) vs. 0.46 (0.09 – 1.78) p=0.150, and PLR was 160.6 (20.2 – 1533.3) vs. 211.2 (50.6–1156.3) p=0.189, for NHL and HL, respectively.Conclusion: The lower values of NLR, MLR, and PLR in NHL indicate lower systemic inflammatory status in NHL than HL patients. Further studies are needed to evaluate dynamic changes of these biomarkers during treatment.
Relationship between Emotional Distress and Workplace Influence on Depressive Symptoms among Online Motorcycle Taxi Drivers
Authors: Merijanti Lie Tanu , Hairunisa Nany , Ridwan Alvin Muhamad , Pusparini Pusparini , Meiyanti Meiyanti , Tjahjadi Muljadi , Isahak Marzuki Bin 
Published: January 2025

Background: The rise of online motorcycle taxi services, driven by the demand for transportation and new technologies, has created a new landscape for drivers. However, despite the benefits, these drivers are not considered employees and are therefore vulnerable to psychosocial risks. This study aimed to investigate the relationship between psychosocial hazards and depressive symptoms among online motorcycle taxi drivers. Methods: A cross-sectional study was conducted, involving 218 online motorcycle taxi drivers in Jakarta, Bogor, Depok, and Tangerang from September to December 2022. The Copenhagen Psychosocial Questionnaire version III was used to assess psychosocial hazards in the workplace and the likelihood of developing depressive symptoms. A multiple linear regression test was used, with a significance level set of p < 0.05.Results: Most respondents were male, and many had worked for over five years, with the majority working more than 8 hours a day. Emotional burden and workplace influences were positively correlated with depressive symptoms (p = 0.017; β = 0.154; and p = 0.002; β = 0.166, respectively). In contrast, the meaning of work and clarity of roles were negatively correlated with depressive symptoms (p = 0.009; β = -0.161; and p = 0.024; β = -0.195, respectively).Conclusion: This study highlights that emotional stress and workplace influence can exacerbate depressive symptoms, while a clear and meaningful work environment have a positive impact. Healthy lifestyle habits are one of the stress management solutions to improve emotional wellness.
Nutrient Composition, Uptake, Yield and Phosphorus Use Efficiency of Black Gram as Influenced by Soil Amendments and Phosphorus in Acidic Soil of Nagaland
Authors: Jamir Temsusangla I. , Sharma Y.K. , Uchoi Albert 
Published: January 2025

Background: Nutrient availability is impaired by soil acidity limiting its accessibility to plants especially phosphorus get immobilized by Fe3+ and Al3+ in acid soil, thereby, resulting in poor growth, seed development and yield. Liming is an imperative soil management practices to keep in check the soil acidity-induced fertility constraints, along with integrated use of fertilizers and organic fertilizers. Methods: The experiment consist of four soil amendments levels [SA0 (control), SA1 (5% LR), SA2 (PSB) and SA3 (5% LR+PSB)] and four phosphorus levels (0, 20, 40 and 60 kg P2O5 ha-1) laid out in randomized block design with three replications. Lime (CaCO3) was applied in furrows 10 days prior to sowing and seed was treated with PSB a day before sowing. Phosphorus levels and the recommended dose of nitrogen and potassium were applied as basal. Result: SA3 (5% LR+PSB) significantly increased the seed yield by 29.9% and stover yield by 35.7% over control. Among P levels application of 60 kg P2O5 ha-1 significantly increased the seed and stover yield and was found highest over preceding P levels but was found at par with P40; application of 40 kg P2O5 ha-1 increased the seed yield by 44.9% and stover yield by 55.9% over control. Interaction effect of soil amendments and phosphorus was significant on seed and stover yieldand nutrient uptake. Phosphorus use efficiency (PUE) decreased with increase in phosphorus levels while P uptake efficiency (PUPE), fertilizer P uptake efficiency (FPUPE), fertilizer P utilization efficiency (FPUTE) and fertilizer P use efficiency (FPUE) were highest at P40.
Prevalensi Problem Depresi pada Pasien Diabetes Mellitus di Puskesmas
Authors: Puspita Salma Fajar , Saepudin  
Published: January 2025

Latar belakang: Gangguan depresi berpotensi menyebabkan ketidakpatuhan terapi dan komplikasi pada pasien Diabetes Mellitus (DM). Masih terdapat hasil yang inkonsisten terkait prevalensi dan faktor risiko depresi pada pasien DM.
Tujuan: Penelitian ini bertujuan untuk menentukan prevalensi pasien DM dengan gejala depresi dan menganalisis faktor-faktor yang berhubungan dengan gejala depresi.
Metode: Penelitian ini merupakan studi observasional cross-sectional melibatkan pasien dewasa penderita DM di beberapa puskesmas di Yogyakarta yang disampling dengan metode purposive sampling. Karakteristik subyek dan gejala depresi diperoleh dengan wawancara. Kuesioner PHQ-9 digunakan untuk menilai gejala depresi. Hubungan antara karakteristik pasien dengan gejala depresi dianalisis dengan Chi-square atau Fisher’s exact test menggunakan SPSS versi 23.
Hasil: Dari total 268 subyek, sebagian besarnya adalah perempuan dan berusia 40-60 tahun. Lebih dari separuh subyek menderita DM < 5 tahun. Sebagian besar subyek memiliki minimal 1 penyakit penyerta dan menggunakan kombinasi antidiabetika oral. Prevalensi gejala depresi pada penelitian ini adalah 36,6%. Faktor yang berhubungan dengan gejala depresi adalah tingkat pendidikan rendah (p=0,026), menjadi tulang punggung keluarga (p=0,000) dan menderita DM selama 5-10 tahun (p=0,027).
Kesimpulan: Pasien DM dengan karakter tertentu lebih rentan mengalami depresi dibandingkan dengan pasien DM lain sehingga perlu mendapat perhatian khusus dari tenaga kesehatan agar tujuan terapi DM tercapai.