bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study
Authors: Chaemsupaphan Thanaboon , Pimolsri Chawanont , Subdee Nichcha , Phaophu Phutthaphorn , Salaemae Marianee , Permpim Parinya , Thongchot Lakkana , Wannasewok Kamonnet , Chotinaiwattarakul Wattanachai , Limsrivilai Julajak 
Published: January 2025

Background: The association between inflammatory bowel disease (IBD) activity and poor sleep quality is reported. However, most research subjectively investigated this issue and lacked long-term follow-up. Objectives: Our study aimed to investigate the prevalence of sleep disturbance in IBD patients across disease activity and evaluate the long-term correlation between disease activity, sleep quality, and quality of life. Design: This prospective observational study assessed sleep quality in patients with IBD. Methods: Patients with IBD were categorized into groups based on clinical activity scores. The sleep questionnaire (Pittsburgh Sleep Quality Index (PSQI)) and IBD questionnaire (IBDQ) were evaluated monthly for 12 months. Seven-day sleep data from wrist actigraphy (Actiwatch®) were collected at initiation and completion. Longitudinal correlation was analyzed. Results: A total of 98 participants were enrolled, consisting of 68 remission, 21 mild, and 9 moderate-to-severe disease activities. At baseline, 60% of participants demonstrated poor sleep quality, defined by a PSQI of >5. The group with greater disease severity reported numerically poorer sleep quality; however, this difference was not statistically significant. On actigraphy, there was no statistically significant difference in sleep latency, wake after sleep onset, or sleep efficiency between the groups. During follow-up, 90 patients responded to questionnaires. The mean PSQI decreased from 7.1 to 5.4 among 22 patients whose active disease transitioned to remission ( p < 0.001). However, the score did not change in 11 patients with remission and developed disease flare (5.9–5.8). The mean PSQI was 7.7 and 6.3 in 4 and 53 patients whose disease remained active and inactive during follow-up, respectively. Multivariable longitudinal analysis revealed that PSQI was independently associated with active disease (odds ratio = 1.22) and inversely associated with IBDQ (β = −2.23). Sleep latency was evaluated by PSQI, and actigraphy was significantly correlated. Conclusions: Patients with IBD frequently experience poor sleep quality, which significantly correlates with active disease and worse quality of life longitudinally.
Chronic Rhinitis Surgery: Association Between Preoperative Severity and Response Rate
Authors: Huang Chien-Yu , Liao Jyun-Yi , Kang Bor-Hwang , Lin Yaoh-Shiang , Hsieh Jun-Wei 
Published: January 2025

Background The success rate of chronic rhinitis surgery varies depending on the patients’ factor and surgical method. While outcomes for nasal obstruction differ, the association between preoperative severity of other rhinitis symptoms, such as rhinorrhea, sneezing, and nasal itching, measured via the reflective total nasal symptom score (rTNSS) remains unevaluated. Objective To evaluate the association between the response rate to surgical treatment of chronic rhinitis and preoperative severity. Methods A retrospective cohort study was conducted among adult patients with chronic rhinitis symptoms refractory to medication and nasal spray for over 6 months and received radiofrequency ablation of inferior turbinates with posterior nasal nerve neurolysis. The primary endpoint was the change from baseline in 24-h rTNSS and nasal obstruction symptom evaluation (NOSE) scores. Postoperative surgery response rate, rTNSS score change, and score improvement ratios were also evaluated. Results A total of 183 patients (110 males, 60.1%) were included in this study. After 3-month follow-up, the preoperative rTNSS was 6.51 ± 2.74 change to 1.70 ± 1.43, and the NOSE score was 56.48 ± 19.90 change to 4.56 ± 7.74. Both scores and all sub-scores showed significant differences when comparing preoperative, 1-month, and 3-month results ( P < 0.05-0.001). The response rate by rTNSS for whole cohort was 78.14 ± 41.44% and 93.99 ± 23.83% at 1- and 3-month follow-up. Subgroup analyses were performed according to individual rTNSS scores and 2 in 1 score groups (ie, 1-2, 3-4, etc) and their relationship to the surgery outcomes. Both preoperative individual score and score groups were significantly associated with all post-operation outcomes ( P = 0.022 to <0.001) in linear regression analysis. Conclusion Patients with more severe preoperative rhinitis symptoms are associated with better response rate, post-operation symptom score changes, and score improvement ratio.
Patient, Caregiver, and Provider Perspectives on Improving Provider-Patient Interactions in Hemodialysis: A Qualitative Study
Authors: Talson Melanie D. , Ferreira da Silva Priscila , Finlay Juli , Rossum Krista , Soroka Kaytlynn V. , McCormick Michael , Desjarlais Arlene , Vorster Hans , Sass Rachelle , James Matthew , Sood Manish M. , Jaure Allison , Pannu Neesh , Tennankore Karthik , Thompson Stephanie , Tonelli Marcello , Bohm Clara 
Published: January 2025

Background: Improving interactions between people receiving hemodialysis and health care providers of facility-based hemodialysis care is a top priority for patients, caregivers, and health care providers. Objective: To identify challenges for high-quality clinical interactions in facility-based hemodialysis care as well as potential solutions. Design: Multicentre qualitative study using focus groups and semi-structured interviews to elicit the perspectives of patients, caregivers, and health care providers. Setting: Five Canadian facility-based hemodialysis centers. Participants: English-speaking adults receiving facility-based hemodialysis for longer than 6 months, their caregivers, and hemodialysis health care providers. Methods: Between May 2017 and August 2018, focus groups and interviews with patients and their caregivers subsequently informed semi-structured interviews with providers. Data were analyzed using inductive thematic analysis with application of a grounded theory approach. Results: A total of 8 focus groups and 44 interviews were completed. Participants included 64 people receiving hemodialysis, 18 caregivers, and 31 health care providers. Communication between health care providers and patients was often characterized as intersections of care (unidirectional) rather than interactions (bidirectional). Challenges were grouped into 4 main themes as follows: (1) culture of care provision; (2) mistrust between patients and health care providers; (3) time constraints for clinical interactions, and (4) lack of collaboration and care coordination among health care team. Potential solutions were identified for each challenge. Limitations: Findings were limited to Canadian context, English-speaking adults, and individuals receiving facility-based hemodialysis in urban centers. Conclusions: Interactions between health care providers and people receiving dialysis are often unidirectional, where the patient is a passive recipient of ideas and information from the health care provider. To promote improved bidirectional interactions, team-based care that includes better tools to improve information transfer, better information regarding roles, and identity of health care team members and opportunities for all members of the health care team, including the people receiving dialysis, to provide input on care plans is required. Trial Registration: Not applicable.
Artificial intelligence in precision medicine for lung cancer: A bibliometric analysis
Authors: Wang Yuchai , Zhang Weilong , Liu Xiang , Tian Li , Li Wenjiao , He Peng , Huang Sheng , He Fuyuan , Pan Xue 
Published: January 2025

Background The increasing body of evidence has been stimulating the application of artificial intelligence (AI) in precision medicine research for lung cancer. This trend necessitates a comprehensive overview of the growing number of publications to facilitate researchers’ understanding of this field. Method The bibliometric data for the current analysis was extracted from the Web of Science Core Collection database, CiteSpace, VOSviewer ,and an online website were applied to the analysis. Results After the data were filtered, this search yielded 4062 manuscripts. And 92.27% of the papers were published from 2014 onwards. The main contributing countries were China, the United States, India, Japan, and Korea. These publications were mainly published in the following scientific disciplines, including Radiology Nuclear Medicine, Medical Imaging, Oncology, and Computer Science Notably, Li Weimin and Aerts Hugo J. W. L. stand out as leading authorities in this domain. In the keyword co-occurrence and co-citation cluster analysis of the publication, the knowledge base was divided into four clusters that are more easily understood, including screening, diagnosis, treatment, and prognosis. Conclusion This bibliometric study reveals deep learning frameworks and AI-based radiomics are receiving attention. High-quality and standardized data have the potential to revolutionize lung cancer screening and diagnosis in the era of precision medicine. However, the importance of high-quality clinical datasets, the development of new and combined AI models, and their consistent assessment for advancing research on AI applications in lung cancer are highlighted before current research can be effectively applied in clinical practice.
Google Trends applications for COVID-19 pandemic: A bibliometric analysis
Authors: Li Hao , Zhang Ning , Ma Xingxing , Wang Yuqing , Yang Feixiang , Wang Wanrong , Huang Yuxi , Xie Yinyin , Du Yinan 
Published: January 2025

Introduction COVID-19 is one of the most severe global health events in recent years. Google Trends provides a comprehensive analysis of the search frequency for specific terms on Google, reflecting the public's areas of interest. As of now, there has been no bibliometric study on COVID-19 and Google Trends. Therefore, the aim of this study is to perform a comprehensive bibliometric analysis of existing Google Trends research related to COVID-19. Methods We retrieved 467 records from the Web of Science™ Core Collection, covering the period from January 1, 2020, to December 31, 2023. We then conducted scientific metric analyses using CiteSpace, VOSviewer, and the Bibliometrix package in R-software to explore the temporal and spatial distribution, author distribution, thematic categories, references, and keywords related to these records. Results A total of 467 valid records, comprising 418 articles and 49 reviews, were collected for analysis. Over the 4 years, the highest number of publications occurred in 2021. The United States had the most published papers, followed by China. Notably, the United States and China had the closest collaborative relationship. Harvard University ranked as the institution with the highest number of published papers. However, there appeared to be a lack of collaboration between institutions. The research hotspots related to COVID-19 in Google Trends encompassed “outbreak,” “epidemic,” “air pollution,” “internet,” “time series,” and “public interest.” Conclusion This study provides a valuable overview of the directions in which Google Trends is being utilized for studying infectious diseases, particularly COVID-19.
Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer
Authors: Henneghan Ashley M , Paolillo Emily W , Van Dyk Kathleen M , Franco-Rocha Oscar Y , Bang Soyeong , Tasker Rebecca , Kaufmann Tara , Haywood Darren , Hart Nicolas H , Moore Raeanne C 
Published: January 2025

Objective Metastatic breast cancer (MBC) is associated with burdensome side effects, including cognitive changes that require ongoing monitoring. Cognitive ecological momentary assessments (EMAs) allow for assessment of individual cognitive functioning in natural environments and can be administered via smartphones. Accordingly, we sought to establish the feasibility, reliability, and validity of a commercially available cognitive EMA platform. Methods Using a prospective design, clinical cognitive and psychosocial assessments (cognitive batteries; patient reported outcomes) were collected at baseline, followed by a 28-day daily EMA protocol that included self-ratings for symptoms and mobile cognitive tests (memory, executive functioning, working memory, processing speed). Satisfaction and feedback questions were included in follow-up data collection. Feasibility data were analyzed using mixed descriptive methods. Test-retest reliability was examined using intraclass correlation coefficients (ICCs) for each EMA, and Pearson's correlation were used to evaluate convergent validity between cognitive EMAs and baseline clinical cognitive and psychosocial variables. Results Fifty-one women with MBC ( n = 51) completed this EMA study. High satisfaction (median 90%), low burden (median 19%), high adherence rates (mean 94%), and 100% retention rate were observed. ICCs for cognitive tests of working memory, executive function, and processing speed were robust (>0.90) and ICC for memory tests acceptable (>0.66). Other correlational findings indicated strong convergent validity for all cognitive and psychosocial EMAs. Conclusion Cognitive EMA monitoring for 28 days is feasible and acceptable in women with MBC, with specific cognitive EMAs (mobile cognitive tests; cognitive function self-ratings) demonstrating strong reliability and validity.
Effects of Early Sport Specialization on Injury Load Management and Athletic Success of National Basketball Association Players
Authors: Sang Luke , Bach Katherine , Feeley Brian T. , Pandya Nirav K. 
Published: January 2025

Background: The effects of early sport specialization on professional athletes’ resilience in handling increased workloads and athletic success have not been fully described. Hypothesis: National Basketball Association (NBA) players who were multisport athletes during high school would be able to withstand higher workloads with lower injury rates and have more athletic success compared with their single-sport peers. Study Design: Descriptive epidemiology study. Methods: Included were first-round NBA draft picks from 2013 to 2023 who had played ≥1 game in their first 3 seasons after being drafted. Athletes who had participated in ≥1 high school sports in addition to basketball were classified as multisport athletes, while those who had only played basketball were classified as single-sport athletes. For each player's first 3 NBA seasons, workload data (number of games played and distance traveled per game/season in meters), injury history, statistical performance (player efficiency rating), and end-of-season award history were collected through the official NBA advanced statistics database and through publicly available records. Results: Overall, 318 athletes were included, of whom 87 (27.4%) were multisport and 231 (72.6%) were single-sport. During their first 3 seasons combined, multisport athletes played in significantly more games (148.9 ± 67.1 vs 125.8 ± 63.8; P < .01), traveled greater total distances (133,183.9 ± 239,923.0 m vs 73,879.5 ± 165,093.9 m; P < .01), and had a significantly lower percentage of games missed due to injury (13.5% vs 16.9%; P < .001) compared with single-sport athletes. There was a significant correlation between increased workload (total distance traveled) and number of injuries in single-sport athletes ( ρ = 0.37; P < .001) but not in multisport athletes ( ρ = 0.14; P = .20). Last, multisport players had a significantly higher player efficiency rating (12.8 ± 11.6 vs 10.5 ± 5.1; P < .05) and award achievement likelihood (40.2% vs 19.0%; P < .001). Conclusion: NBA players who had participated in multiple sports during high school demonstrated an ability to withstand higher workloads while having fewer games missed due to injury when compared with players who had only played basketball. Furthermore, athletes who delayed sport specialization had greater statistical and award success in their professional careers than those who focused on early single-sport specialization.
Evaluation of Factors Associated With Short-term Failure After Primary Isolated PCL Reconstruction: A Study of Patients From the Swedish and Norwegian Knee Ligament Registries
Authors: Zsidai Bálint , Winkler Philipp W. , Naarup Eric , Olsson Ebba , Horvath Alexandra , Moatshe Gilbert , Lind Martin , Musahl Volker , Hamrin Senorski Eric , Samuelsson Kristian 
Published: January 2025

Background: The rate of subjective failure after isolated primary posterior cruciate ligament reconstruction (PCL-R) is relatively high, requiring an improved understanding of factors associated with inferior outcomes. Purpose: To determine the association between patient and injury-related factors and total (surgical and clinical) failure at 2 years after PCL-R based on data from the Swedish National Knee Ligament Registry (SNKLR) and the Norwegian Knee Ligament Registry (NKLR). Study Design: Cohort study; Level of evidence, 3. Methods: Patients with primary isolated PCL-R registered between January 1, 2004 (NKLR), or January 1, 2005 (SNKLR), and December 31, 2020, were included. The primary study outcome was the risk of PCL-R failure at the 2-year follow-up, either surgical (≤2 years of index surgery) or clinical (Knee injury and Osteoarthritis Outcome Score [KOOS] Quality of Life subscale [QoL] <44) failure. Risk factors for failure were estimated utilizing univariable and multivariable logistic regression analyses. Results: Among the 189 included patients (36.0% from the SNKLR and 64.0% from the NKLR), the rate of 2-year surgical failure was 5.8%, while the rate of clinical failure was 45.0%. Multivariable analysis showed a negative association between the baseline KOOS QoL and the risk of PCL-R failure (OR, 0.74; 95% CI, 0.57-0.97; P = .027). Univariable analysis indicated a positive association between traffic-related injury mechanism and PCL-R failure risk (OR, 3.11; 95% CI, 1.48-6.50; P = .0026), with a further positive association shown in the adjusted (OR, 6.08; 95% CI, 2.00-18.50; P = .0015) and multivariable (OR, 6.11; 95% CI, 2.01-18.55; P = .0014) models. An area under the curve of 0.70 (95% CI, 0.60-0.80) was reported for the final multivariable model, implying at best poor to acceptable ability of the model to estimate PCL-R failure risk based on the variables considered. Conclusion: Patients with isolated primary PCL-R had a high (45%) rate of short-term clinical failure, and traffic-related injury was associated with increased odds of failure. No modifiable risk factors were determined as potential predictors of failure. Clinicians treating patients with isolated PCL-R associated with a traffic-related injury mechanism should be aware of a >6-fold increased odds of revision surgery and inferior knee-related quality of life at short-term follow-up.
Practice, Experiences, and Facilitators of Simulation-Based Training During One Year of Implementation in 30 Hospitals in Tanzania
Authors: Kamala Benjamin A. , Moshiro Robert , Kalabamu Florence S. , Kjetil Torgeirsen , Guga Godfrey , Githiri Beatrice , Samson Justine , Chavala Philimon , Qorro Grace , Kayera Damas , Kamala Ivony , Massay Catherine , Mdoe Paschal , Daudi Vickfarajaeli , Mduma Esto , Mwashemele Shally , Bundala Felix , Ersdal Hege , Lafontan Sara Rivenes 
Published: January 2025

Introduction Enhancing the proficiency of healthcare workers (HCWs) in handling birth-related complications is crucial for reducing maternal and newborn morbidity and mortality. To achieve this, the Safer Births Bundle of Care offers a comprehensive set of innovative, simulation-based training interventions designed to strengthen the skills and competencies of HCWs working as skilled birth attendants. Objective To describe the use of in-situ low-dose, high-frequency simulation-based training, and the experiences of this usage among HCWs and stakeholders at facilities in Tanzania. Methods This mixed-methods study included quantitative and qualitative data collected between July 2021 and July 2022 across 30 health facilities in five regions of Tanzania. NeoNatalie Live (NNL) simulators were installed for independent skills and scenario training, and in-situ facilitator-led team simulations were introduced. The training frequency was analyzed using descriptive and analytical statistics, and mentorship and supervision reports were analyzed using qualitative content analysis. Results A large and sustained number of in-situ NNL skill-training sessions ( n = 35,101) and facilitator-led team simulations ( n = 266) were conducted during the first year. Clinical burden per HCW did not affect the frequency of NNL skills training at the health facility level ( r = −0.16, p = .40) nor facilitator-led team simulations. There was a positive but weak correlation between the frequency of facilitator-led team simulations and NNL skills training ( r = 0.34, p = .05). Qualitative data showed a high degree of motivation and participation among all stakeholders, and active use of hospital data, both clinical indicators and training data, was perceived as a success factor. Conclusion Facilitator-led in-situ simulation training was more likely to occur where individual skills-training sessions were recorded. Training sessions took place regardless of the increased workload.
Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials
Authors: Fukuda-Doi Mayumi , Koga Masatoshi , Thomalla Götz , Jensen Märit , Inoue Manabu , Yoshimura Sohei , Miwa Kaori , Gerloff Christian , Davis Stephen M , Donnan Geoffrey A , Ma Henry , Hacke Werner , Ringleb Peter , Wu Ona , Schwamm Lee H , Warach Steven , Toyoda Kazunori 
Published: January 2025

Introduction: The effects of imaging-based intravenous thrombolysis on outcomes based on patient sex remain unclear. We aimed to investigate whether outcomes among patients with stroke with an unknown onset time and treated with imaging-based intravenous thrombolysis are influenced by their sex. Patients and Methods: This study was a pooled analysis of individual patient-level data acquired from the Evaluation of unknown Onset Stroke thrombolysis trials. Patients treated with imaging-based intravenous thrombolysis for stroke with an unknown onset time were included. The primary outcome was a favourable outcome (modified Rankin Scale score 0–1) at 90 days. The sex-based difference in outcomes was studied using mixed-effect logistic or ordinal regression models, considering potential heterogeneity across trials. Results: Out of 509 patients in total, 204 (40.1%) were women. Compared with men, women were older and more likely to have atrial fibrillation. Baseline National Institutes of Health Stroke Scale score was higher and hours from last-known-well to treatment were longer for women than for men. Favourable outcomes occurred less often among women than among men. However, multivariate adjustment revealed a non-significant association between female sex and favourable outcome (adjusted odds ratio: 1.04 [95% confidence interval: 0.66–1.52], p = 0.98). Discussion and conclusion: Pooled data from the included clinical trials showed that women with ischaemic stroke with an unknown onset time had worse functional outcomes following imaging-based intravenous thrombolysis than did men. However, this sex-based difference can be explained by the higher age and more severe clinical status at onset among women.