bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindful tourism: nothing left behind–creating a circular economy society for the tourism industry of Krabi, Thailand
Authors: Pongsakornrungsilp Pimlapas , Pongsakornrungsilp Siwarit 
Published: July 2021

PurposeThis research aims to demonstrate how the circular economy is employed to drive the sustainability of the tourism industry in Krabi, Thailand, through the concept of mindful consumption and service-dominant logic (hereafter S-D logic).Design/methodology/approachA seven-year longitudinal study (2013–2020) was conducted through four studies from different perspectives, including macro, meso and micro levels of development in Krabi province.FindingsKrabi tourism stakeholders have collaborated to co-create green culture and behavior whereby the value network among stakeholders plays an important role in driving the circular economy in practice.Research limitations/implicationsThis study provides an understanding of how the circular economy society has been co-created. However, further research should be conducted in other tourism cities by focusing on the key success factors that drive the circular economy.Originality/valueThe longitudinal study with multi-perspective micro, macro and meso levels of development in this study has shed the light on how the circular economy (CE) policy can be turned into practice.
How do managers promote workplace learning? Learning-oriented leadership in daily work
Authors: Wallo Andreas , Kock Henrik , Reineholm Cathrine , Ellström Per-Erik 
Published: July 2021

Purpose
The purpose of this paper is to explore managers’ learning-oriented leadership, and what conditions managers face when working with the promotion of employees’ learning.

Design/methodology/approach
Data was collected through semi-structured interviews with managers in three manufacturing firms. Verbatim expressions of the interview participants were analysed using stepwise analytical procedures.

Findings
The managers used many kinds of activities to promote learning. Most common were activities related to learning opportunities that arose during daily work. The identified activities ranged from being planned to occurring more spontaneously. Depending on the situation or the learning activity, the managers used different behaviours to promote learning. They supported, educated and confronted employees, and they acted as role models. Factors constraining the implementation of learning-oriented leadership included limited resources, and a lack of commitment from top management, employees or the managers themselves.

Research limitations/implications
Future research should study learning-oriented leadership from the employees’ perspective.

Practical implications
Managers’ notions about learning and development constitute an important condition for learning-oriented leadership. Therefore, managers need to be trained in how to promote their employees’ learning at work.

Originality/value
This study adds to the limited knowledge of how managers carry out a learning-oriented leadership in their daily work. The findings contribute knowledge regarding managerial practices of promoting employees’ workplace learning by identifying different activities and behaviours that managers could incorporate into their leadership.
Effects of antibiotics on the viability of and toxin production by Clostridium botulinum
Authors: Yutani Masahiro , Matsumura Takuhiro , Fujinaga Yukako 
Published: July 2021

AbstractClostridium botulinum causes infant and adult intestinal botulism by colonizing in the intestine and producing botulinum neurotoxin (BoNT). Antimicrobial agents are not currently used for treatment due to the potential facilitation of BoNT production and bacterial cell lysis, which releases toxins into the intestinal lumen. In this study, we analyzed effects of four antibiotics on the viability of and BoNT production by four C. botulinum group I strains. Our results indicate that metronidazole rapidly reduced their viability without enhancing BoNT production. Antibiotics with these properties may promote elimination of C. botulinum from the intestines while maintaining low levels of BoNT.
Resources do not limit compensatory response of a tallgrass prairie plant community to the loss of a dominant species
Authors: Chaves Francis A. , Smith Melinda D. 
Published: July 2021

AbstractThe effect of species loss on ecosystem productivity is determined by both the functional contribution of the species lost, and the response of the remaining species in the community. According to the mass ratio hypothesis, the loss of a dominant plant species, which has a larger proportionate contribution to productivity, is expected to exert an overwhelming effect on this important ecosystem function. However, via competitive release, loss of a dominant species can provide the opportunity for other plant species to establish, thrive and become abundant in the community, potentially compensating for the function lost. Furthermore, if resource limitation is removed, then the compensatory response of function to the loss of a dominant species should be greater and more rapid than if resources are more limiting.To evaluate how resources may limit compensation of above‐ground productivity to the loss of a dominant plant species, we experimentally removed the C4perennial tallgrass,Andropogon gerardii, from intact plant communities. We added water for 4 years, as well as nitrogen in the fourth year, to test the effect of resource limitation on the compensatory response.Overall, above‐ground biomass production increased in the remaining community with both water and nitrogen addition. However, this increase in biomass production was not sufficient to fully compensate for the loss ofA. gerardii, indicating water and nitrogen were not limiting short‐term compensation in this community.Following the removal of the dominant species, there was reordering of species abundances in the community, rather than changes in species richness. The C4grassBouteloua curtipendulawas the most responsive species, increasing by 57.9% in abundance with water addition and 91.0% with both water and nitrogen addition. Despite this dramatic increase in abundance, its short stature and lower per capita biomass production prevented this species from compensating for the loss ofA. gerardii.Synthesis. Short‐term compensation after the loss of a dominant plant species can be hastened by increased resource availability, but ultimately full compensation appears to be limited by the presence and abundance of species in the remaining community that possess traits that allow them compensate for the species lost.
Sequence Stratigraphy of the Lower Cretaceous Uraniferous Measures and Mineralization of the Sandstone‐hosted Tamusu Large Uranium Deposit, North China
Authors: LIU Bo , SHI Zhiqiang , PENG Yunbiao , ZHANG Pengfei , LI Peng 
Published: July 2021

AbstractThe Bayingobi basin is the Mesozoic–Cenozoic basin in North China in which the Tamusu uranium deposit is located. The ore‐target layer of the deposit is the Lower Cretaceous Bayingobi Formation, which developed as a fan delta‐shallow lacustrine deposit. The distributary channel sand body of the fan delta plain and the underwater distributary channel sand body of the fan delta front formed a favorable uranium reservoir, so the study of sequence stratigraphy is extremely important to understanding the genesis of uranium deposits. On the basis of field investigation and a large number of borehole logs, the high resolution sequence stratigraphy of the Lower Cretaceous is divided and the system tracts of different periods are established. The relationship between deposition, interlayer oxidation and uranium enrichment is discussed. The Lower Cretaceous Bayingobi Formation can be divided into two fourth‐order sequences (Sq1 and Sq2). The lower member of the Bayingobi Formation is referred to as Sq1, which is composed of a falling‐stage system tract (FSST) on top. On the other hand, the upper member of the Bayingobi Formation is referred to as Sq2, which is composed of a lowstand system tract (LST), transgressive system tract (TST) and highstand system tract (HST). The lowstand system tract forms a favorable stratigraphic structure (mud‐sand‐mud formation) with the lacustrine mudstone of the overlying transgressive system tract, that is conducive for the migration of uranium‐bearing oxygen water. The organic matter and pyrite in the fan delta sand body, as well as the dark mudstone in the distributary bay, provided a reducing medium for uranium mineralization. The ore body mainly occurs in the distributary channel, underwater distributary channel or the mouth bar of the fan delta. As a result of the moderate thickness, high permeability, favorable barrier and rich reducing medium, the rich ore body mainly occurs in the underwater distributary channel and mouth bar sand body of the delta front. Based on study of the sequence stratigraphy, the model of the sequence, sedimentation and mineralization of the uranium deposit is established, which enriches uranium metallogenic theory and provides a reference for exploration of the same type of uranium deposits.
Histone methyltransferase SETD1A participates in lung cancer progression
Authors: Du Mei , Gong Piping , Zhang Yun , Liu Yanguo , Liu Xiaozhen , Zhang Feng , Wang Xiuwen 
Published: July 2021

AbstractLung cancer is the leading cause of cancer‐related death worldwide, with an estimated 1.2 million deaths each year. Despite advances in lung cancer treatment, 5‐year survival rates are lower than ~15%, which is attributes to diagnosis limitations and current clinical drug resistance. Recently, more evidence has suggested that epigenome dysregulation is associated with the initiation and progress of cancer, and targeting epigenome‐related molecules improves cancer symptoms. Interestingly, some groups reported that the level of methylation of histone 3 lysine 4 (H3K4me3) was increased in lung tumors and participated in abnormal transcriptional regulation. However, a mechanistic analysis is not available. In this report, we found that the SET domain containing 1A (SETD1A), the enzyme for H3K4me3, was elevated in lung cancer tissue compared to normal lung tissue. Knockdown of SETD1A in A549 and H1299 cells led to defects in cell proliferation and epithelial‐mesenchymal transition (EMT), as evidenced by inhibited WNT and transforming growth factor β (TGFβ) pathways, compared with the control group. Xenograft assays also revealed a decreased tumor growth and EMT in the SETD1A silenced group compared with the control group. Mechanistic analysis suggested that SETD1A might regulate tumor progression via several critical oncogenes, which exhibited enhanced H3K4me3 levels around transcriptional start sites in lung cancer. This study illustrates the important role of SETD1A in lung cancer and provides a potential drug target for treatment.
The effect of preoperative jaundice in the surgical management of gallbladder carcinoma: An updated meta‐analysis
Authors: Lv Tian‐Run , Hu Hai‐Jie , Regmi Parbatraj , Liu Fei , Li Fu‐Yu 
Published: July 2021

AbstractBackgroundAn updated meta‐analysis was performed on the significance of preoperative jaundice in the surgical management of gallbladder carcinoma (GBC).MethodsA thorough database searching was performed in PubMed, EMBASE, and the Cochrane library for comparative studies between jaundiced and non‐jaundiced GBC patients. RevMan5.3 and Stata 13.0 software were used for statistical analysis. A total of nine measured outcomes were identified: resectability, R0 resection rate, concurrent bile duct resection, major hepatectomy, vital vascular reconstruction, combined adjacent organ resections, postoperative morbidities, mortalities, and overall survival (OS).ResultsA total of eight studies were finally included. Newcastle– Ottawa Quality Assessment Scale was used for evaluating the quality of all included studies and the details were recorded in Table S1. Our pooled results revealed that preoperative jaundice was associated with a significantly lower resectability (p < 0.00001), a significantly lower R0 resection rate (p < 0.00001), a significantly higher concurrent bile duct resection rate (p < 0.00001), major hepatectomy rate (≥3 segments) (p < 0.00001), and vital vascular reconstruction rate (portal vein or hepatic artery) (p < 0.00001). Moreover, jaundiced patients experienced more postoperative morbidities (p < 0.00001), mortalities (p < 0.0001), and worse OS (p < 0.00001). However, jaundice was not related to combined adjacent organ resections (p = 0.58).ConclusionPreoperative jaundice in GBC patients seems to be contraindicated to curative resection and the optimal therapeutic strategies should be identified via multidisciplinary team rather than surgery alone. Candidates for curative surgery should be highly selected and experienced centers are preferred. More significant well‐designed studies are required for further exploration.
Potential positive effects of bariatric surgery on healthcare resource utilisation
Authors: Chadwick Chiara , Burton Paul R. , Playfair Julie , Shaw Kalai , Wentworth John , Liew Danny , Fineberg Daniel , Way Andrew , Brown Wendy A. 
Published: July 2021

AbstractBackgroundTo determine whether a bariatric surgical procedure is associated with a reduction in healthcare utilisation among patients with obesity and high pre‐procedural healthcare needs.MethodsDesign: Retrospective cohort study. Setting: Tertiary Victorian public hospital. Participants: Twenty‐nine adults who underwent publicly funded primary bariatric surgery between 2008 and 2018 at the Alfred Hospital, Melbourne and had high resource use over the year prior to surgery, defined as at least two of ≥3 hospital admissions, ≥7 inpatient bed days for obesity‐related co‐morbidities or inpatient hospital costs ≥$10 000. Main outcome measures: Change in inpatient and outpatient resource use.ResultsAfter 1 year following bariatric surgery, total hospital bed days decreased from 663 to 80 and the median (Q1, Q3) per patient decreased from 7 (4.5, 15) to 5 (2.25, 9.75) (p = 0.001) and the total number of hospital admissions fell from 118 to 67 (p < 0.001). The median cost of inpatient care decreased from $11 405 ($4408, $22251) to $3974 ($0, $4325) per annum (p < 0.001). The total and median number of outpatient attendances did not significantly change 12 months after bariatric surgery, but the demand for outpatient services unrelated to bariatric surgery declined by a median of four visits per patient (p = 0.013).ConclusionsThe evidence from this small pilot study suggests that Bariatric surgery has the potential to decrease resource use and inpatient hospital costs over a 1‐year time frame for obese patients with high resource use. These data will be used to design a prospective randomised controlled trial to provide more definitive information on this important issue.
An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis
Authors: Pichi Francesco , Neri Piergiorgio , Hay Steven , Parrulli Salvatore , Zicarelli Federico , Invernizzi Alessandro 
Published: July 2021

AbstractPurposeTo analyse vitreous anatomy patients with anterior uveitis (AU) using swept source optical coherence tomography (SS‐OCT).MethodsPatients with newly diagnosed AU and healthy participants were scanned using 16‐mm SS‐OCT B‐scans and 12 × 12 mm cube centred at the fovea. Linear SS‐OCT scans were evaluated to identify the premacular bursa (PB) above the macula and the Cloquet’s canal above the optic disc. A dynamic evaluation of the 12 × 12 mm cube enableden facemeasurement of the vertical and horizontal diameters of the PB and the presence/absence of communication between the PB and Cloquet’s canal.ResultsOne hundred and thirty‐five subjects were included in the study. Forty‐five patients were healthy (mean age 33.47 years).En facemeasurements of the horizontal and vertical PB mean diameters were 5.2 mm and 4.7 mm. In 90 subjects with AU (mean age 30.10 years), the mean horizontal and vertical diameter of the PB were significantly larger (p < 0.01). Thirty‐seven eyes with AU presented with cystoid macular oedema (CME). The mean diameters of the PB in this subgroup were significantly larger (p < 0.01). In 75% of the entire cohort (51% of eyes in the control group, 87% of eyes with AU and 100% of eyes with AU and CME), a channel connecting the PB and Cloquet’s canal could be identified.ConclusionsSS‐OCT identification of a connecting channel between the PB and the Cloquet’s canal suggests that inflammatory cytokines may drain from the anterior chamber through this system of channels, thus increasing the risk of CME.
Hospitalization for adverse events under abiraterone or enzalutamide exposure in real‐world setting: A French population‐based study on prostate cancer patients
Authors: Scailteux Lucie‐Marie , Despas Fabien , Balusson Frédéric , Campillo‐Gimenez Boris , Mathieu Romain , Vincendeau Sébastien , Happe André , Nowak Emmanuel , Kerbrat Sandrine , Oger Emmanuel 
Published: July 2021

AimsSafety profiles of abiraterone and enzalutamide rely mainly on Phase III clinical trials. Our objective was to estimate the incidence rate ratio (IRR) for certain adverse events leading in real life to hospitalization (atrial fibrillation, acute heart failure, ischaemic heart disease, acute kidney injury [AKI], ischaemic stroke, torsade de pointe/QT interval prolongation, hepatitis and seizure), comparing abiraterone to enzalutamide. We also set out to discuss previously identified safety signals.MethodUsing the French National Health Insurance System database, all patients newly exposed to abiraterone or enzalutamide between 2013 and 2017 and followed until 31 December 2018 were targeted. IRRs for each event were estimated using a Poisson model in a sub‐population of patients without contraindications or precautions for use for either treatment.ResultsAmong 11 534 new users of abiraterone and enzalutamide, AKI (IRR 1.42, 95% CI: 1.01–2.00), liver monitoring suggestive of hepatic damage (IRR 3.06, 95% CI: 2.66–3.53) and atrial fibrillation (IRR 1.12, 95% CI: 1.05–1.19) were significantly more often observed with abiraterone than with enzalutamide.ConclusionOur study provides knowledge on abiraterone and enzalutamide real‐life safety profiles, especially for events leading to hospitalization. Despite several limitations, including the lack of clinical data, the safety signal for AKI under abiraterone is in line with results of an analysis of the French pharmacovigilance database, which requires further specific investigations. Enlightening the clinicians' therapeutic choices for patients treated for prostate cancer, our study should lead to clinicians being cautious in the use of abiraterone.
A placebo‐controlled investigation of the analgesic effects, abuse liability, safety and tolerability of a range of oral cannabidiol doses in healthy humans
Authors: Arout Caroline A. , Haney Margaret , Herrmann Evan S. , Bedi Gillinder , Cooper Ziva D. 
Published: July 2021

AimsPreclinical studies demonstrate that cannabidiol (CBD) elicits an antinociceptive response in animal models of neuropathic pain; in humans, limited data are available to support such analgesic effects. Few studies have examined CBD's analgesic effects when administered without other compounds, and little is known regarding dose‐dependent effects in noncannabis users.MethodsThis double‐blind, placebo‐controlled, within‐subject outpatient clinical laboratory study sought to determine the analgesic effects, abuse liability, safety and tolerability of acute CBD (0, 200, 400 and 800 mg orally) in healthy noncannabis‐using volunteers (n = 17; 8 men, 9 women). Outcomes included experimental pain threshold and pain tolerance using the cold pressor test (CPT), subjective ratings of CPT painfulness and bothersomeness, subjective ratings of abuse liability and mood, and cardiovascular measures, which were assessed at baseline and several time points after drug administration. Data analyses included repeated measures analysis of variance (ANOVA) with planned comparisons.ResultsCBD failed to consistently affect pain threshold and tolerance in the CPT relative to placebo. All doses of CBD increased ratings of painfulness compared to placebo (P < .01). Further, CBD had dose‐dependent, modest effects on mood and subjective drug effects associated with abuse liability. Oral CBD was safe and well tolerated, producing small decreases in blood pressure (P < .01).ConclusionCBD did not elicit consistent dose‐dependent analgesia and in fact increased pain on some measures. Future studies exploring CBD‐induced pain relief should consider using a more extensive pain assessment paradigm in different participant populations.
Amplifying children's voices within photovoice: Emerging inclusive education practices in Indonesia
Authors: Bonati Michelle L. , Andriana Elga 
Published: July 2021

Accessible summary

Inclusive education is being developed for the first time in Indonesia.

Children with learning disabilities have been excluded from regular schools in the past, but now some schools are welcoming these students.

Supporting social inclusion is important for students with learning disabilities who have been excluded from participating in school and their communities.

This article talks about how a research method called photovoice can be used to support social inclusion in school.

This article shows how photovoice can be used to understand how students with learning disabilities think and feel about social inclusion, their communities and belonging.

AbstractBackgroundInclusive education is a recent phenomenon in Indonesia. Students with learning disabilities have been historically and currently marginalised within most schools and communities, with limited opportunities for social inclusion.MethodsPhotovoice, a qualitative, participatory methodology was implemented to engage 31 students with learning disabilities and without disabilities in projects connected with their school curricula that focused on the overarching themes of social inclusion, belonging and community. The students served as co‐researchers, which involved taking photographs and thematically analysing them during individual interviews and during group discussions. The project culminated with a public photo exhibition and presentations by the students. Data collection occurred over 6 weeks, in two schools in Yogyakarta, Indonesia, and further cross‐case analysis of the data was conducted by the authors. The research question examined was as follows: How do students with and without disabilities perceive social inclusion, belonging and their community during a photovoice project in Indonesia?FindingsThree themes emerged in response to the research question focused on the overarching topics of social inclusion, belonging and community. These themes included: (1) Inclusive Characters, (2) Cultural and Civic Engagement in the Community, and (3) Self‐Determination.ConclusionsPhotovoice methodology can provide a pedagogical tool within inclusive education practices. Photovoice also provided opportunities to amplify the voices of students with learning disabilities to express their experiences and perspectives of social inclusion in their schools and communities. Students with and without disabilities also developed a sense of agency to transform the communities in which they belong.