bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the impacts of anthropogenic drainage structures on hydrologic connectivity using high‐resolution digital elevation models
Authors: Bhadra Sourav , Li Ruopu , Wu Di , Wang Guangxing , Rekabdar Banafsheh 
Published: August 2021

AbstractDelineating accurate flowlines using digital elevation models is a critical step for overland flow modeling. However, extracting surface flowlines from high‐resolution digital elevation models (HRDEMs) can be biased, partly due to the absence of information on the locations of anthropogenic drainage structures (ADS) such as bridges and culverts. Without the ADS, the roads may act as “digital dams” that prevent accurate delineation of flowlines. However, it is unclear what variables for terrain‐based hydrologic modeling can be used to mitigate the effect of “digital dams.” This study assessed the impacts of ADS locations, spatial resolution, depression processing methods, and flow direction algorithms on hydrologic connectivity in an agrarian landscape of Nebraska. The assessment was conducted based on the offset distances between modeled drainage crossings and actual ADS on the road. Results suggested that: (a) stream burning in combination with the D8 or D‐Infinity flow direction algorithm is the best option for modeling surface flowlines from HRDEMs in an agrarian landscape; (b) increasing the HRDEM resolution was found significant for facilitating accurate drainage crossing near ADS locations; and (c) D8 and D‐Infinity flow direction algorithms resulted in similar patterns of drainage crossing at ADS locations. This research is expected to result in improved parameter settings for HRDEMs‐based hydrologic modeling.
Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8‐methoxypsoralen concentration and by replacing plasma with saline
Authors: Hähnel Viola , Brosig Andreas‐Michael , Ehrenschwender Martin , Burkhardt Ralph , Offner Robert , Ahrens Norbert 
Published: August 2021

AbstractBackgroundExtracorporeal photopheresis (ECP), an apheresis‐based therapy for various immunological diseases, works mainly by inducing apoptosis in lymphocytes. Several factors influence the efficacy of ECP with the photosensitizer 8‐methoxypsoralen (8‐MOP) and ultraviolet light A (UVA). This study aimed to optimize treatment by varying the 8‐MOP starting concentration and the cell suspension medium.Materials and MethodsAll patients (n = 13) included in this study received photopheresis as medically indicated. Cells collected with a Spectra Optia apheresis system were suspended in plasma or physiological saline (NaCl) and incubated with 200 ng/ml versus 340 ng/ml photosensitizer before UVA irradiation (Macogenic G2 or UVA PIT system). Lymphocyte apoptosis and caspase activity were analyzed by flow cytometry and fluorimetry, and residual 8‐methoxypsoralen concentrations by liquid chromatography–mass spectrometry.ResultsRaising the 8‐MOP starting concentration significantly increased lymphocyte apoptosis, with values of 22% versus 35% (plasma) and 28%–46% (NaCl) at 24 h post‐ECP and 37% versus 86% (plasma) and 74% versus 97% (NaCl) at 48 h for 200 ng/ml versus 340 ng/ml. Pre‐transfusion residual 8‐MOP levels were 168 ng/ml (plasma) and 162 ng/ml (NaCl) versus 290 ng/ml (plasma) and 266 ng/ml (NaCl) for the lower versus higher dose, respectively.DiscussionHence, 8‐MOP concentration influences the efficacy of photopheresis as lymphocyte apoptosis rates were significantly higher with the higher starting concentration and with NaCl versus plasma. This indicates that increased 8‐MOP starting doses and saline as additional suspension medium could help in improving ECP's efficacy.
An Internal State Variable Elastoviscoplasticity-Damage Model for Irradiated Metals
Authors: Cho H. E. , Zbib H. M. , Horstemeyer M. F. 
Published: August 2021

Abstract
This study presents an irradiation-dependent internal state variable (ISV) elastoviscoplasticity-damage constitutive model that accounts for nuclear irradiation hardening and embrittlement of the irradiated polycrystalline materials. The irradiation effects were added to the coupled plasticity-damage kinetics with consideration of the structure–property relationships. The present irradiation-dependent elastoviscoplasticity-damage model was compared with the lab deformation experimental data of irradiated oxygen-free high conductivity (OFHC) copper, modified 9Cr-1Mo steel, and Ti-5Al-2.5Sn. The results show excellent agreement over the entire stress–strain curves at various irradiation doses. Because the ISV model, before the irradiation plasticity-damage addition, had been used on over 80 different metal alloys, it is anticipated that this nuclear irradiation supplement will also allow for application to many more irradiated metal alloys.
Friction and Wear Behavior of a Physical Vapor Deposition Coating Studied Using a Micro-Scratch Technique
Authors: Khlifi Kaouther , Dhiflaoui Hafedh , Ben Aissa Chokri , Barhoumi Najoua , Ben Cheikh Larbi Ahmed 
Published: August 2021

Abstract
CrSiN coating was deposited by physical vapor deposition (PVD) magnetron sputtering on XC100 steel substrate. Microstructural and morphological properties were studied using scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and atomic force microscopy (AFM). Nanoindentation and scratching experiments were conducted to study the mechanical and adhesion behavior. Multi-pass scratch tests were conducted under different sliding conditions. Results showed that CrSiN coating has a dense and compact nanocomposite microstructure consisting of CrN nanocrystallites and SiN amorphous matrix. The CrSiN thin film exhibit hardness and Young's modulus of 30.52 ± 1.85 GPa and 338.32 ± 13.5 GPa, respectively. The H/E, H3/E2, and 1/HE2 ratios were also calculated (H/E ≈ 0.09, H3/E2 ≈ 0.024, and 1/HE2 ≈ 2.86 × 10−07) and used to predict and assess the elastic/plastic and wear resistance. Critical loads LC1, LC2, and LC3 obtained with scratch test, were, respectively, 11.5 ± 0.12, 16.6 ± 0.23, and 20 ± 0.35 N. Multi-pass scratch were analyzed and the friction coefficient (COF), the damage mechanism, and wear volume were determined. The use of an energetic approach allowed to determine the energetic wear coefficient. CrSiN coating revealed a low friction coefficient (around 0.1) and a low energetic wear coefficient (6.3 × 10−7 mm3/N.m). In addition, it was found that multi-pass scratch method has the potential to extract relevant information about wear behavior.
Effect of P2O5 Impurities and Fluoride Ions on The Rheological Properties of Porous Glasses and Bismuth-Containing Composites Based on Them
Authors: Antropova T. V. , Stolyar S. V. , Anfimova I. N. , Girsova M. A. 
Published: August 2021

Abstract
The results of a study of the rheological properties (shrinkage on heating, viscosity) of porous glasses (PGs) obtained as a result of through acid leaching of two-phase sodium borosilicate glass doped with small additives of P2O5 and fluoride ions, as well as bismuth-containing PGs and quartzoid glasses based on them, depending on the temperature of the heat treatment of the PG and in comparison with the characteristics of the samples obtained from sodium borosilicate glass without additives, are presented. It is found that doping glass with the indicated impurities leads to a decrease in the thermal resistance of the obtained PGs and bismuth-containing PGs. The introduction of bismuth nitrate into PG in the case of the low-temperature treatment (at 120°C) lowers the temperature for the same viscosity values of quartzoid glasses by 15–20°C, in contrast to samples without additives, as well as from higher-temperature treatment (at 650°C) PGs with additives.
Economic evaluation of covered stents for transjugular intrahepatic portosystemic stent shunt in patients with variceal bleeding and refractory ascites secondary to cirrhosis
Authors: Mattock Richard , Tripathi Dhiraj , O'Neill Frank , Craig Joyce , Tanner Jennifer , Patch David , Aithal Guruprasad 
Published: August 2021

ObjectivesTransjugular intrahepatic portosystemic stent shunt (TIPSS) is clinically effective in variceal bleeding and refractory ascites; however, the cost-effectiveness of TIPSS has yet to be evaluated in the UK. This study aimed to establish the cost-effectiveness of (i) pre-emptive TIPSS versus endoscopic band ligation (EBL) in populations with variceal bleeding and (ii) TIPSS versus large volume paracentesis (LVP) in refractory ascites.MethodsA cost-utility analysis was conducted with the perspective including healthcare costs and quality-adjusted life years (QALYs). A Markov model was constructed with a 2-year time horizon, health states for mortality and survival and probabilities for the development of variceal bleeding, ascites and hepatic encephalopathy. A survival analysis was conducted to extrapolate 12-month to 24-month mortality for the refractory ascites indication. Uncertainty was analysed in deterministic and probabilistic sensitivity analyses.ResultsTIPSS was cost-effective (dominant) and cost saving for both indications. For variceal bleeding, pre-emptive TIPSS resulted in 0.209 additional QALYs, and saved £600 per patient compared with EBL. TIPSS had a very high probability of being cost-effective (95%) but was not cost saving in scenario analyses driven by rates of variceal rebleeding. For refractory ascites, TIPSS resulted in 0.526 additional QALYs and saved £17 983 per patient and had a 100% probability of being cost-effective and cost saving when compared with LVP.ConclusionsTIPSS is a cost-effective intervention for variceal bleeding and refractory ascites. TIPSS is highly cost-saving for refractory ascites. Robust randomised trial data are required to confirm whether pre-emptive TIPSS is cost saving for variceal bleeding.
Intimate partner violence (IPV) in male and female orthopaedic trauma patients: a multicentre, cross-sectional prevalence study
Authors: Downie Samantha , Kanya Iuliana , Madden Kim , Bhandari Mohit , Jariwala Arpit C 
Published: August 2021

ObjectivesIdentify the proportion of patients attending fracture clinics who had suffered intimate partner violence (IPV) within the past year.DesignPowered cross-sectional study using validated participant self-reported questionnaires.Setting and participantsAdult trauma patients (no gender/age exclusions) attending one of three Scottish adult fracture clinics over 16-month period (from October 2016 to January 2018).Primary outcome measureNumber of participants answering ‘yes’ to the Woman Abuse Screening Tool question: ‘In your current relationship over the past twelve months, has your partner ever abused you physically/emotionally/sexually?’ResultsOf 336 respondents, 46% (156/336 known) were women with 65% aged over 40 (212/328 known). The overall prevalence of IPV within the preceding 12 months was 12% 39/336) for both male and female patients. The lifetime prevalence of IPV among respondents was 20% (68/336). 38% of patients who had experienced IPV within the past 12 months had been physically abused (11/29). None of the patients were being seen for an injury caused by abuse. Two-thirds of respondents thought that staff should ask routinely about IPV (55%, 217/336), but only 5% had previously been asked about abuse (18/336).ConclusionsThis is the first study worldwide investigating the prevalence of IPV in fracture clinics for both male and female patients. 12-month prevalence of IPV in fracture clinic patients is significant and not affected by gender in this study. Patients appear willing to disclose abuse within this setting and are supportive of staff asking about abuse. This presents an opportunity to identify those at risk within this vulnerable population.
Comparison of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament with posterior quadratus lumborum block for perioperative analgesia in laparoscopic nephrectomy: a protocol for a randomised, prospective, parallel group, non-inferior trial
Authors: Huang Xiao , Sun Yuan , Shi Rong , Ma Danxu , Wu Anshi , Wang Yun , Yang Yinan 
Published: August 2021

ObjectiveAnterior quadratus lumborum block at the lateral supra-arcuate ligament (QLBA) is a new method for postoperative pain relief in patients undergoing abdominal surgery. Perioperative QLBA is effective, but it has not been compared with posterior quadratus lumborum block (QLB2). The present study aims to evaluate the postoperative pain of patients undergoing laparoscopic nephrectomy surgery with QLBA versus QLB2.Methods/designThis study is a randomised, prospective, parallel group, non-inferior trial. All patients undergoing laparoscopic nephrectomy surgery will be randomised 1:1 to the QLBA group or the QLB2 group with general anaesthesia. The objective of the trial is to evaluate the postoperative pain of patients undergoing laparoscopic nephrectomy surgery with QLBA (n=50) versus QLB2 (n=50). The primary outcome for this trial is the Visual Analogue Scale scores at rest and activity (dynamic pain scores are assessed with a cough or a trial to sit up in bed) 2 hours after surgery between patients who receive QLBA versus QLB2. The secondary objectives will be to compare (1) pain at rest and activity 0.5 hour, 2 hours, 24 hours, 48 hours after surgery; (2) the time spent on block operation; (3) the blocked dermatomal coverage 5 min and 15 min after block operation; (4) intraoperative opioid consumption; (5) types and doses of the rescue analgesic after surgery; (6) nausea and vomiting score within 24 hours after surgery; (7) time from the end of surgery to the first onset significant pain; (8) patient satisfaction score.DiscussionClinical experience has supported that QLB is a very effective postoperative analgesic method, and we will answer the following questions in this trial: Will both approaches have the same analgesic effect and duration? Will the QLBA have a non-inferior postoperative analgesic effect compared with QLB2 or the QLBA be able to prolong the duration of analgesia after surgery? The results of this study could have actual clinical applications that could help to reduce postoperative pain and shorten hospital stays.Ethics and disseminationThe study design was approved by the ethical committee of Beijing Chao-Yang Hospital, Beijing, China (2020-ke-321). The trial results will be published in peer-reviewed journals and at conferences.Trial registration numberChiCTR2000035354.
How many infants may have died in low-income and middle-income countries in 2020 due to the economic contraction accompanying the COVID-19 pandemic? Mortality projections based on forecasted declines in economic growth
Authors: Shapira Gil , de Walque Damien , Friedman Jed 
Published: August 2021

ObjectivesWhile COVID-19 has a relatively small direct impact on infant mortality, the pandemic is expected to indirectly increase mortality of this vulnerable group in low-income and middle-income countries through its effects on the economy and health system performance. Previous studies projected indirect mortality by modelling how hypothesised disruptions in health services will affect health outcomes. We provide alternative projections, relying on modelling the relationship between aggregate income shocks and mortality.DesignWe construct a sample of 5.2 million births by pooling retrospective birth histories reported by women in Demographic and Health Surveys conducted in 83 low-income and middle-income countries between 1985 and 2018. We employ regression models with country-specific fixed-effects and flexible time trends to estimate the impact of gross domestic product per capita on infant mortality rate. We then use growth projections by the International Monetary Fund to predict the effect of the economic downturn in 2020 on infant mortality.ResultsWe estimate 267 208 (95% CI 112 000 to 422 415) excess infant deaths in 128 countries, corresponding to a 6.8% (95% CI 2.8% to 10.7%) increase in the total number of infant deaths expected in 2020.ConclusionsThe findings underscore the vulnerability of infants to the negative income shocks such as those imposed by the COVID-19 pandemic. While efforts towards prevention and treatment of COVID-19 remain paramount, the global community should also strengthen social safety nets and assure continuity of essential health services.
Risk events during intrahospital transport of patients from the emergency department: a prospective observational study
Authors: Neal-Williams Tom , Walker Kimberly , Lines Travis , Ugoni Antony , Taylor David McDonald 
Published: August 2021

BackgroundWe aimed to determine the incidence, nature of and predisposing factors for risk events (REs) that occur during the intrahospital transport of patients from the ED.MethodsWe undertook a prospective, observational study of intrahospital patient transports from a single ED between 30 January and 20 March 2020. An investigator attended each transport and recorded any RE on a specifically designed data collection document. An RE was any mishap, even if not foreseen, that had the potential to cause the patient harm. A patient equipment number was assigned based on the number of pieces of equipment required during the transport. Poisson regression generated incidence rate ratios (IRRs) and determined risk factors for REs.ResultsOf 738 transports, 289 (39.1%, 95% CI 35.6% to 42.8%) had at least one RE. The total of 521 REs comprised 125 patient-related, 279 device-related and 117 line/catheter-related REs. The most common included trolley collisions (n=142), intravenous fluid line catching/tangling (n=93), agitation/aggression events (n=31) and cardiac monitoring issues (n=31). Thirty-four (6.5%) REs resulted in an undesirable patient outcome, most commonly distress and pain. Predisposing factors for REs included an equipment number ≥3 (IRR 5.68, 95% CI 3.95 to 8.17), transport to a general ward (IRR 2.68, 95% CI 2.12 to 3.39), hypertension (IRR 1.93, 95% CI 1.07 to 3.50), an abnormal temperature and a GCS<14.ConclusionsREs are common in transport of patients from the ED and can result in undesirable patient outcomes. Adequate pre-transfer preparation, especially securing equipment and lines, would result in a reduced risk.
Early toxicity and clinical outcomes after chimeric antigen receptor T-cell (CAR-T) therapy for lymphoma
Authors: Brammer Jonathan E , Braunstein Zachary , Katapadi Aashish , Porter Kyle , Biersmith Michael , Guha Avirup , Vasu Sumithira , Yildiz Vedat O , Smith Sakima A , Buck Benjamin , Haddad Devin , Gumina Richard , William Basem M , Penza Sam , Saad Ayman , Denlinger Nathan , Vallakati Ajay , Baliga Ragavendra , Benza Raymond , Binkley Philip , Wei Lai , Mocarski Mason , Devine Steven M , Jaglowski Samantha , Addison Daniel 
Published: August 2021

BackgroundChimeric antigen receptor T-cell (CAR-T) infusion is associated with early toxicity. Yet, whether early toxicity development holds ramifications for long-term outcomes is unknown.MethodsFrom a large cohort of consecutive adult patients treated with CAR-T therapies for relapsed or refractory lymphomas from 2016 to 2019, we assessed progression-free survival (PFS), by toxicity development (cytokine release syndrome (CRS), neurotoxicity, or cardiotoxicity]. We also assessed the relationship of toxicity development to objective disease response, and overall survival (OS). Multivariable regression was utilized to evaluate relationships between standard clinical and laboratory measures and disease outcomes. Differences in outcomes, by toxicity status, were also assessed via 30-day landmark analysis. Furthermore, we assessed the effects of early anti-CRS toxicity therapy use (at ≤grade 2 toxicity) on maximum toxicity grade observed, and long-term disease outcomes (PFS and OS).ResultsOverall, from 102 CAR-T-treated patients, 90 were identified as treated with single-agent therapy, of which 88.9% developed toxicity (80 CRS, 41 neurotoxicity, and 17 cardiotoxicity), including 28.9% with high-grade (≥3) events. The most common manifestations were hypotension at 96.6% and fever at 94.8%. Among patients with cardiac events, there was a non-significant trend toward a higher prevalence of concurrent or preceding high-grade (≥3) CRS. 50.0% required tocilizumab or corticosteroids. The median time to toxicity was 3 days; high grade CRS development was associated with cardiac and neurotoxicity. In multivariable regression, accounting for disease severity and traditional predictors of disease response, moderate (maximum grade 2) CRS development was associated with higher complete response at 1 year (HR: 2.34; p=0.07), and longer PFS (HR: 0.41; p=0.02, in landmark analysis), and OS (HR: 0.43; p=0.03). Among those with CRS, relative blood pressure (HR: 2.25; p=0.004), respectively, also associated with improved PFS. There was no difference in disease outcomes, or maximum toxicity grade (CRS, neurotoxicity, or cardiotoxicity) observed, based on the presence or absence of the use of early CRS-directed therapies.ConclusionsAmong adult lymphoma patients, moderate toxicity manifest as grade 2 CRS after CAR-T infusion may associate with favorable clinical outcomes. Further studies are needed to confirm these findings.
Development of a lupus nephritis suboptimal response prediction tool using renal histopathological and clinical laboratory variables at the time of diagnosis
Authors: Helget Lindsay N , Dillon David J , Wolf Bethany , Parks Laura P , Self Sally E , Bruner Evelyn T , Oates Evan E , Oates Jim C 
Published: August 2021

ObjectiveLupus nephritis (LN) is an immune complex-mediated glomerular and tubulointerstitial disease in patients with SLE. Prediction of outcomes at the onset of LN diagnosis can guide decisions regarding intensity of monitoring and therapy for treatment success. Currently, no machine learning model of outcomes exists. Several outcomes modelling works have used univariate or linear modelling but were limited by the disease heterogeneity. We hypothesised that a combination of renal pathology results and routine clinical laboratory data could be used to develop and to cross-validate a clinically meaningful machine learning early decision support tool that predicts LN outcomes at approximately 1 year.MethodsTo address this hypothesis, patients with LN from a prospective longitudinal registry at the Medical University of South Carolina enrolled between 2003 and 2017 were identified if they had renal biopsies with International Society of Nephrology/Renal Pathology Society pathological classification. Clinical laboratory values at the time of diagnosis and outcome variables at approximately 1 year were recorded. Machine learning models were developed and cross-validated to predict suboptimal response.ResultsFive machine learning models predicted suboptimal response status in 10 times cross-validation with receiver operating characteristics area under the curve values >0.78. The most predictive variables were interstitial inflammation, interstitial fibrosis, activity score and chronicity score from renal pathology and urine protein-to-creatinine ratio, white blood cell count and haemoglobin from the clinical laboratories. A web-based tool was created for clinicians to enter these baseline clinical laboratory and histopathology variables to produce a probability score of suboptimal response.ConclusionGiven the heterogeneity of disease presentation in LN, it is important that risk prediction models incorporate several data elements. This report provides for the first time a clinical proof-of-concept tool that uses the five most predictive models and simplifies understanding of them through a web-based application.