bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manifestasi Klinis Apendisitis Akut pada Anak di Rumah Sakit Islam Banjarnegara
Authors: Yuandi Niko , Nuchalida Mirza , Ujianto Agus , Safila Meta , Riayani Suripto 
Published: June 2021

Apendisitis akut adalah kegawatdaruratan abdomen paling sering. Terutama menyerang anak-anak. Jadi lamanya morbiditas akibat laparotomi yang tidak diinginkan dan pada saat terlambat mendiagnosis apendisitis akut perlu diperhatikan. Penelitian ini dilakukan 35 anak kasus apendisitis akut terbukti dengan adanya perubahan morfologi apendix. Nyeri perut terjadi pada semua pasien dan fosa iliaka kanan adalah tempat paling sering. Sejumlah kasus melaporkan migrasi nyeri fosa iliaka kanan dari regio periumbilikalis. Nausea dan muntah adalah gejala umum lainnya. Peningkatan suhu merupakan prediksi pada perforasi. Gambaran klinis lainya penting terkait dengan jenis apendisitis. Morfologi sangat penting bagi dokter bedah untuk menilai diagnosis klinis dan dalam jangka panjang akan menjadi dasar pengalaman dan keahlian tentang apendisitis serta meningkatkan penilaian klinis dokter.
Population Migration and The Challenges of Economic Growth in North Sumatera in Year (1988-2020)
Authors: Nasution Zulkarnain , Ali Al Ihsan Muhammad 
Published: June 2021

Population increase has the impact on demographic transition (changes in population structure). Indonesia is entering the demographic bonus period, there is the increase in the percentage of the working age population. According to theory, population can affect economic growth (in this study the effect on gross domestic product or GDP). One of the demographic components that affect population composition is population mobility or migration. This study used migration, risk migration and dependency ratios to show the latest patterns / trends of population mobility (last 20 years). The results showed that the variables in this study had a positive and negative effect on GDP growth. Of the three variables, the greatest influence is given by percentage of dependency ratio variable. The results of this study showed that migration and risk migration had negative impact on economic growth while the dependency ratio had a positive impact on economic growth. North Sumatra must be optimistic to increase economic growth by utilizing components that can boost the economy and one of them is the dependency ratio.
Rehabilitación de una protesis fija convencional
Authors: Salas Luz Elena Nápoles , Taylor Saralyn López y , Santana Belinda Pérez , Sánchez Ana Bertha Olmedo , Santana Sabrina del Rosario Pérez , Palomera Olga Rocío Manzo , González Víctor Flores , Campoy Carlos Eduardo Bracamontes , Manzo Michelle Jacqueline Sánchez 
Published: June 2021

Hoy en día la necesidad de estética se ha convertido en uno de los aspectos más importantes de la odontología restauradora, por tal motivo se han desarrollado diversos materiales y técnicas para la solución protética definitiva de la Odontología restauradora de los últimos tiempos. La finalidad es describir las consideraciones generales de la prótesis convencional, así como las indicaciones, contraindicaciones, ventajas y desventajas.
Una de las desventajas de una prótesis convencional, es el desgaste de los órganos dentales que son los pilares, a veces es una decisión muy difícil en realizar este tratamiento si no tenemos otra alternativa de rehabilitación.
DEVELOPMENT OF THE COMPONENT COMPOSITION OF AMINO ACID MIXTURES FOR THE NUTRITION OF PATIENTS WITH PHENYLKETONURIA
Authors: Shylau V. V. , Zhurnia H. A. 
Published: June 2021

According to the Ministry of Health in the Republic of Belarus in 2019, there were about 500 patients with phenylketonuria (PKU). Phenylketonuria is a hereditary disease associated with a violation of the metabolism of amino acids, in particular phenylalanine (FA). This disease is accompanied by the accumulation of phenylalanine and its toxic products in the tissues, which leads to severe damage to the central nervous system, manifested in the form of impaired mental development. Many years of world experience shows that for the treatment of such patients, a special diet is prescribed using amino acid mixtures that do not contain phenylalanine or contain it in small amounts, as well as low-protein products based on starch, which are necessary to ensure an adequate energy value of the diet.
The article presents the stages of development of the component composition of domestic amino acid mixtures for the nutrition of patients with phenylketonuria, taking into account their age characteristics.
RATING OF THE COMPETITIVENESS OF KETCHUPS SALES IN
REPUBLIC OF BELARUS
Authors: Roshchinа E. V. , Vasiuta T. V. 
Published: June 2021

The assessment of the competitive advantage is based on the essence of value, which is the source of obtaining an advantage and dependents on its content, the scale of distribution and other conditions. In this case, the use of indicators is the most important condition and understandable for the consumer, because these indicators are the subject of any competition. The analysis of the competitiveness shows that most of the proposed methods are based on the use of various financial coefficients for analyzing the activities of enterprises, the competitiveness of certain types of products. The determination of the competitiveness index allows you to establish the rating strength of the competitive advantages of products trademarks.
In order to determine the competitive advantages of ketchup, presented in the trade network of Belarus taking into account the indexes of consumer and economic parameters, 15 studied samples have been calculated. The authors identified the fallowing competitive advantages of ketchups: composition, category, brand, packing, labeling, quality level. Further, the coefficients of the weight of the competitive advantages of the samples were calculated and the assessment of the total value of the competitive advantages was carried out, taking into account the degree of the weight. Based on the calculated indexes of consumer and economic parameters, the competitiveness of the samples has been determined and the rating of ketchup has been also assigned.
As a result of the research, the rating is the following: among ketchups of the category «extra» — ketchup of the trademark «Schedro», among ketchups of the category «highest» — ketchup «Gusto», among ketchups of the category «the first» — ketchup «Iam Heppy», among ketchups of the category «the second» — ketchup «Tomato Signor».
Características clínico-quirúrgicas de la atresia esofágica en el Instituto Nacional de Salud del Niño San Borja, Lima, Perú. 2015-2017
Authors: Ortiz-Rios Gianmarco , Molina-Ccanto Indira , Espíritu Nora , Apaza-León José , Grados-Godenzi Deborah , Gonzales-Farromeque Augusto 
Published: June 2021

Objetivo: Describir las características clínico-quirúrgicas y sociodemográficas de pacientes con atresia esofágica (AE) del Instituto Nacional de Salud del Niño San Borja (INSN-SB) 2015-2017. Material y métodos: Estudio observacional descriptivo de casos con AE 2015-2017. Los datos se procesaron y analizaron en el programa SPSS v20, las variables cualitativas fueron expresadas en frecuencias absolutas y relativas. Resultados: Se analizaron 74 casos con AE, 55,4% (n=41) fueron de sexo masculino. Según edad gestacional 45 a término, 28 pre-término y un post-término. El 59,5% tuvieron peso adecuado al nacer. 28,4% tuvieron control prenatal (CPN) completo y 68,9% no tuvieron diagnóstico prenatal de AE. La atresia con fistula traqueo-esofágica (FTE) distal fue la más frecuente con 74,3% (n=55). Se presentó sialorrea en 55 pacientes (74,3%) y disnea en 54 (72,9%). Predominaron las malformaciones cardiacas en el 27,1%, seguida por digestivas 20,3% y genitourinarias 17,6%. Solo 26 tuvieron síndromes asociados, VACTERL en 12 casos. La anastomosis termino-terminal y cierre de fistula se realizó en 55 pacientes (74,3%). 48 presentaron complicaciones tempranas, predominando sepsis (20,3%) y 46 complicaciones tardías, siendo reflujo gastroesofágico el más frecuente 29,7%. La mortalidad fue 10,8%. Conclusiones: La mayoría fue de sexo masculino, a término, con adecuado peso al nacer y sin CPN. La AE con FTE distal fue la más frecuente. Sialorrea y disnea fueron los síntomas predominantes y malformaciones cardiacas y digestivas las más asociadas. La anastomosis término-terminal y cierre de fístula fue la técnica más frecuente, como complicaciones sepsis y reflujo gastroesofágico. La mortalidad fue baja.
Blind liver biopsy: a 17-year experience
Authors: Urganci Nafiye , Kurtaraner Tugce , Kalyoncu Derya , Merve Usta Ayse , Yilmaz Ozguven Banu 
Published: June 2021

Objectives: Liver biopsy is the gold standard for assessing liver inflammation, necrosis and fibrosis. The aim of the study is to evaluate clinical indications and histopathological results of percutaneus liver biopsy. Materials and methods: A total of 516 children who underwent blind liver biopsy were evaluated retrospectively. Results: Blind liver biopsy was performed for chronic active hepatitis B in 50% of the cases (n=260), neonatal cholestasis in 14% (n=68), autoimmune hepatitis in 7.7% (n=40), Wilson disease in 7.3% (n=38), isolated elevation of the liver enzymes in 5% (n=26), chronic active hepatitis C in 4.2% (n=22), metabolic disease in 3.4% (n=17), malignancies in 2.2% (n=11) and the others in 3.4% (n=17). Major complications were observed in 0.19% of the cases (n=1) and minor complications such as pain at the biopsy site in 13.5% of the cases (n=70), hypotension and tachycardia in 1.9% (n=10). Conclusions: Blind liver biopsy is a safe method in diagnosing liver diseases in childhood.
Leeches alleviates diabetic macroangiopathy by increasing nitric oxide production in rat aorta and restoring endothelium-dependent vasodilatation
Authors: Fang Zhaohui , Hu Xiu , Chen Zhi , Xie Jing , Wu Di , Yin Yundong 
Published: June 2021

IntroductionDiabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose level over a prolonged period, leading to severe damage in tissues including the heart, blood vessels, eyes and the kidneys. Danzhi Jiangtang Capsule (DJC) is an effective drug for diabetes, but the mechanism responsible for its efficacy remains unknown. This study aimed to explore the effective ingredient of DJC that ameliorated diabetes and the possible mechanisms.Material and methodsWe orally treated streptozotocin (STZ)-induced diabetic rats with 540 mg/kg DIC or the same dose of its four active components, namely Leeches, Pseudostellaria Polysaccharides (PP), Paeonia Suffruticosa Andr (PSA) and Rehmannia Glutinosa Libosch (RGL), respectively for 8 weeks.ResultsAlthough all of these components could reduce blood glucose levels in diabetic rats, the extent of alleviation of DJC was more pronounced than all of its four ingredients. Unlike the other three components, Leeches is the only effective ingredient of DJC that decreased tetrahydrobiopterin (BH4) oxidation to activate endothelial nitric oxide synthase (eNOS), and increased nitric oxide (NO) production, leading to improved endothelium-dependent relaxation both in diabetic rats and in immortalized human mesangial cells under the stimulation of high glucose.ConclusionsLeeches could alleviate diabetic macroangiopathy by inhibiting NO release in endothelial cells under high-glucose condition.
Pour une réflexion sur l’écriture de l’histoire de l’Algérie du temps présent
Authors: Arezki Saphia 
Published: June 2021

Pour une réflexion sur l’écriture de l’histoire de l’Algérie du temps présent : recension de Peyroulou, Jean-Pierre, Histoire de l’Algérie depuis 1988, Paris, La Découverte, coll. Repères, 2020, 128 p.
Bank Disclosure and Stock Price Synchronicity: Evidence from Dual-Banking System Countries
Authors: Ashraf Nadia , Chughtai Sumayya 
Published: June 2021

In stock markets, information plays a crucial role in determining trading dynamics and price discovery. In the investment decisions, an investor may have incomplete information regarding the firm-specific factors because of information asymmetry. Therefore, investors rely on market factors. Extensive work has been done on stock price synchronicity (SYNCH) from the dual banking system viewpoint. Therefore, the present study examines the association of Stock Price Synchronicity with Bank’s Disclosure items and Shariah Compliance using data of 138 banks for 09 years (2011-2019) by taking dual banking system countries. We consider 11 countries, i.e., Bahrain, Bangladesh, Kuwait, Lebanon, Malaysia, Pakistan, Qatar, Saudi Arabia, Turkey, UAE, and Yemen, for analysis. We select different banks based on these countries' dual banking systems and exclude two countries (UAE & Yemen) due to data availability issues. Data of 138 banks is analyzed using specific statistical techniques like descriptive statistics, correlation, Fisher-type unit-root test, endogeneity test, and generalized method of moments (GMM) by using STATA. In the analysis, we found that bank disclosure has a significant positive relationship with SYNCH. However, shariah compliance banks have a significant negative relation with SYNCH. Moreover, control variables which include banks profitability, and leverage have a significant positive relationship with SYNCH. The banks' size has a significant negative relationship because the size affects the banks according to the market.
Keywords: Stock Price Synchronicity, Bank’s Disclosure, Asymmetric Information, Banking Sector.
JEL Classification: D82, G21
Clinical outcomes of isolated redo mitral valve replacement in patients with mitral prosthetic heart valve dysfunction
Authors: Güner Ahmet , Kadiroğulları Ersin , İyigün Taner , Gürbak İsmail , Onan Burak , Aydın Ünal , Gürsoy Mustafa , Ertürk Mehmet 
Published: June 2021

Objectives: Redo mitral valve replacement (redo-MVR) represents a clinical challenge due to a higher rates of peri-operative morbidity and mortality.
Patients and Methods: This retrospective study enrolled a total of 103 patients who underwent isolated redo-MVR due to prosthetic valve dysfunction. Patients who had an isolated bypass, low echocardiographic quality, history of repeated re-replacements (more than twice), paravalvular leak repair without preoperative and intraoperative transesophageal echocardiography examination, isolated congenital surgery or isolated open-heart surgical intervention (of any type) without a valve procedure at their first or later operations were excluded. The primary endpoint of the study was in-hospital death. Secondary endpoint included individual morbidity.
Results: A total of 103 patients (mean age: 50.7 13.4 years; male: 58) who underwent isolated redo-MVR were enrolled in this study. The most common complaint of the patients at admission was obstruction or heart failure-related symptoms (80.6%) and the primary indication for redo-MVR was prosthetic valve thrombosis in 58 patients (56.3%). In-hospital mortality was 12.6% (13 patients). The post-operative complications included major bleeding (n=11) post-operative infection (sepsis, mediastinitis, pneumonia, wound infection, n=15), low cardiac output syndrome (n=10), acute kidney injury (n=17), pericardial effusion with tamponade (n=10), pleural effusion requiring hospitalization and drainage (n=18), ischemic stroke (n=4), fatal ventricular arrhythmia (n=1), peripheral embolism (n=1), moderate to severe paravalvular leak (n=5). There was not any catastrophic heart laceration.
Conclusion: In-hospital mortality and complications of the isolated redo-MVR in our center are acceptable. With a well-defined protocol and appropriate patient selection, mortality in emergencies cases may be reduced.
The Effect of Discharge Information Calendar on Healthy Lifestyle Behaviors of Patients after Coronary Artery Bypass Graft Surgery
Authors: Afacan Merve , Ünver Seher 
Published: June 2021

Objectives: To evaluate the effect of discharge information calendar on healthy lifestyle behaviors (HLB) of patients who underwent coronary artery bypass graft (CABG) surgery.
Patients and Methods: This randomized controlled study was carried out on 68 patients (study group=33; control group=35) who underwent CABG surgery between 10.11.2017-10.10.2018. Data were collected from the patient information form and HLB Scale-II. The patients were visited by the researcher one day before their discharge and verbal information was given about the HLB. Discharge information calendar that is designed as a desktop calendar and includes 14 main headings on HLB was used to inform the patients in the study group. HLB of the patients were evaluated at the day before discharge, 2nd and 6th weeks following discharge.
Results: The mean scale scores obtained from the 2nd and 6th weeks of the study group were significantly higher compared with the control group (p<0.001).
Conclusion: The information provided using discharge information calendar to the patients after CABG surgery are effective in gaining HLB for the patients. It is recommended to use visual and written materials (such as the discharging information calendar) to inform patients and help patients to remember the information during the post-discharge period.
Education 4.0: An Remote Approach for Training of Intelligent Automation and Robotic During COVID19
Authors: Smajic Hasan , Duspara Toni 
Published: June 2021

The COVID-19 pandemic confronts universities with great challenges to maintain research and teaching activities with as little contact as possible. Lecturers currently have to migrate to Internet teaching. In most cases, e-learning and digital tools are used to continue online courses to replace classroom teaching. But current online approaches are limited to just lectures and theoretical mathematical exercises. In this paper it will be shown how practical exercises can be carried out remotely via internet in a real technical environment. Experimental laboratory equipment for automation technology and mechatronics is always associated with high costs. The reason for the high investments are the costs for different intelligent devices within an automation solution and the costs for extensive engineering. Beyond the costs, the number of workstations usually does not correspond to the required number of students to be trained. In this case, the same exercises have to be repeated several times, which also leads to in-creased personnel costs.
Remote laboratories are a very cost-effective solution for these problems. This paper describes how this goal can be achieved by implementing a WBT server (WBT - Web-Based Training Server) and a Java-based client-server architecture. The idea behind a remote controlled laboratory is to use web technologies and the Internet as communication infrastructure to perform an experimental part of the training with programmable automation devices. First of all, a detailed requirement profile for the laboratory was developed. Primarily technical, didactical and organizational requirements are concerned. In addition, the laboratory is to improve the education of the students by interactive, problem-oriented learning on real industrial automation components. The aim of the training is to learn suitable working methods for the design (engineering) of complete automation solutions starting from simple to medium complex machines and plants.
Inhibition of HMG-CoA Reductase Activity from Active Compounds of Ginger (Zingiber officinale): In-Silico Study
Authors: Rosario Trijuliamos Manalu  , Imelia Omega Meheda  , Cintya Octaviani  
Published: June 2021

ABSTRAK

Koleterol merupakan salah satu dari lemak tubuh dalam asam lemak bebas dan ester, yang termasuk komponen utama selaput sel otak dan saraf. Namun, tidak jarang kolesterol menjadi penyebab penyakit terutama penyakit jantung yang terus meningkat setiap tahunnya di Indonesia. Sehingga perlu strategi pengobatan yang efektif dan aman dengan melakukan penelitian tanaman Indonesia sebagai upaya kemandirian bahan baku obat. Tujuan dari penelitian ini adalah untuk menentukan aktivitas penghambatan dari senyawa aktif tanaman Jahe pada HMG-KoA reduktase secara in-silico melalui penambatan molekul. Senyawa aktif yang digunakan dalam penelitian ini curcumin, capsaisin, gingerol, paradol, shogaol dilakukan docking molekuler menggunakan software PLANTS dengan tujuan untuk mengetahui score docking dan interaksi kelima senyawa terhadap enzim HMG-KoA reduktase yang berperan terhadap metabolism lemak/kolesterol. Senyawa pembanding yang digunakan adalah simvastatin dan atorvastatin yang merupakan obat lini pertama untuk pengobatan displipidemia. Hasil score docking menunjukkan bahwa kelima senyawa aktif yang digunakan sebagai ligan, menunjukkan score docking yang lebih rendah dibandingkan dengan ligan pembanding, sehingga kelima senyawa aktif ini mampu untuk menghambat biosintesis kolesterol atau kandidat obat baru pengganti simvastatin dan atorvastatin serta berpotensi sebagai dyslipidemia.

ABSTRACT
Cholesterol is one of the body's fats in free fatty acids and esters, which are the main components of brain and nerve cell membranes. However, it is not uncommon for cholesterol to be the cause of disease, especially heart disease, which continues to increase every year in Indonesia. So it needs an effective and safe treatment strategy by conducting research on Indonesian plants as an effort to be independent of medicinal raw materials. The aim of this study was to determine the inhibitory activity of the active compound of Ginger plant on HMG-CoA reductase in-silico through molecular anchoring. The active compounds used in this study were curcumin, capsaicin, gingerol, paradol, shogaol. Molecular docking was carried out using PLANTS software with the aim of knowing the docking score and the interaction of the five compounds with the HMG-CoA reductase enzyme that plays a role in fat/cholesterol metabolism. Comparative compounds used are simvastatin and atorvastatin which are first-line drugs for the treatment of dysplipidemia.