bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation of an improved precipitation data set from multisource information over the Tibetan Plateau
Authors: Hong Zhongkun , Han Zhongying , Li Xueying , Long Di , Tang Guoqiang , Wang Jianhua 
Published: March 2021

AbstractPrecipitation over the Tibetan Plateau (TP) known as Asia’s water tower plays a critical role in regional water and energy cycles, largely affecting water availability for downstream countries. Rain gauges are indispensable in precipitation measurement, but are quite limited in the TP that features complex terrain and the harsh environment. Satellite and reanalysis precipitation products can provide complementary information for ground-based measurements, particularly over large poorly gauged areas. Here we optimally merged gauge, satellite, and reanalysis data by determining weights of various data sources using artificial neural networks (ANNs) and environmental variables including elevation, surface pressure, and wind speed. A Multi-Source Precipitation (MSP) data set was generated at a daily timescale and a spatial resolution of 0.1° across the TP for the 1998–2017 period. The correlation coefficient (CC) of daily precipitation between the MSP and gauge observations was highest (0.74) and the root mean squared error was the second lowest compared with four other satellite products, indicating the quality of the MSP and the effectiveness of the data merging approach. We further evaluated the hydrological utility of different precipitation products using a distributed hydrological model for the poorly gauged headwaters of the Yangtze and Yellow rivers in the TP. The MSP achieved the best Nash-Sutcliffe efficiency coefficient (over 0.8) and CC (over 0.9) for daily streamflow simulations during 2004–2014. In addition, the MSP performed best over the ungauged western TP based on multiple collocation evaluation. The merging method could be applicable to other data-scarce regions globally to provide high quality precipitation data for hydrological research.
Beatriz Palacios: Ukamau’s Cornerstone (1974–2003)
Authors: Seguí Isabel 
Published: March 2021

Beatriz Palacios’s instrumental role in the Ukamau group has been largely ignored by film historiography and criticism. The authorial persona of her comrade and husband, Jorge Sanjinés, has eclipsed Palacios’s work and ideas. Her erasure is due to the perspectives chosen to analyze Ukamau (male-centered auteurist and formalist approaches) and to the almost exclusive use of the voice of Sanjinés (interviews, essays, and films interpreted in an authorial key) to construct the group’s history. Ignoring the contribution and importance of Palacios’s work and not accounting for her share in the authorship of the films made during the years they lived and worked together impedes a correct understanding of the complexity of the production context and the amplitude of the contribution of Ukamau to Latin American cinema. While her work as a producer is increasingly recognized, delving into her roles as a disseminator of political cinema in alternative circuits, evaluator of the impact of the movies on the popular classes, and documentary director completes the portrait of her all-encompassing life and career. En gran medida, el papel instrumental de Beatriz Palacios en el grupo Ukamau ha sido ignorado por la historiografía y la crítica cinematográficas. La persona autoral de su camarada y esposo, Jorge Sanjinés, ha eclipsado la obra e ideas de Palacios. Dicha eliminación se debe a las perspectivas elegidas para analizar Ukamau (enfoques y formalistas) y al uso casi exclusivo de la voz de Sanjinés (entrevistas, ensayos y películas interpretadas en clave autoral) para construir la historia del grupo. Ignorar la contribución e importancia del trabajo de Palacios, así como su participación en la autoría de las películas realizadas durante los años que vivieron y trabajaron juntos, impide una correcta contribución de Ukamau al cine latinoamericano. Mientras que su trabajo como productora es cada vez más reconocido, ahondar en su labor como divulgadora de cine político en circuitos alternativos, evaluadora del impacto de las películas en las clases populares y directora de documentales, completa debidamente retrato de su vida y carrera.
Before the “Ecologically Noble Savage”: Gendered Representations of Amazonia in the Global Media in the 1970s
Authors: Sarzynski Sarah 
Published: March 2021

An analysis of media representations of the Amazon and indigenous peoples reveals how media producers and filmmakers foregrounded discourses naturalizing gendered and racialized differences that distinguished the Amazon from the West in the 1970s, a decade during which the Brazilian military dictatorship promoted development projects in Amazonia. These representations often sexualized indigenous peoples and the Amazon itself, portraying them as primitive, cannibal savages, animals or part of nature, or victims of exploitation. The “Othering” of the Amazon and Amazonians was further elaborated through a discourse of binary oppositions that portrayed Western white men as explorers and exploiters who dominated the screen, scripts, studies, and development projects even if they were doomed to fail. By relying on a symbolic system of difference, global media coverage and films about Amazonia in the 1970s were complicit in legitimizing authoritarian decrees promoting large-scale development that depicted indigenous peoples and the environment as obstacles. Un análisis de las representaciones mediáticas de la Amazonía y sus pueblos indígenas revela cómo, en la década de 1970, productores y cineastas mediáticos resaltaron discursos que naturalizaron las diferencias de género y racializadas con las que se distinguían a la Amazonía del Occidente en una época durante la cual la dictadura militar brasileña promovió proyectos de desarrollo en la región. Dichas representaciones a menudo sexualizaban a los pueblos indígenas y a la Amazonía misma, retratándolos como primitivos, caníbales salvajes, animales o elementos naturales, o víctimas de explotación. La “otredad” de la Amazonía y los amazónicos se elaboró a través de un discurso de oposiciones binarias que retrataba a los hombres blancos occidentales como exploradores y explotadores que dominaban la pantalla, los guiones, los estudios y los proyectos de desarrollo, incluso si estos estaban condenados al fracaso. Al confiar en un sistema simbólico de diferencia basado en oposiciones binarias y estereotipos, la cobertura mediática global y las películas sobre la Amazonía en la década de 1970 fungieron como cómplices en la legitimación de los tipos de proyectos y políticas llevados a cabo en la región.
Transgressive Female Sexuality and Desire in Contemporary Colombian Cinema: Hermida’s La luciérnaga and Rodríguez’s Señoritas
Authors: Valderrama-Burgos Karol 
Published: March 2021

The contemporary Colombian films made by women La luciérnaga (Hermida, 2016) and Señoritas (Rodríguez, 2013) subvert patriarchal gender norms of classic Colombian film narratology through their representation of lesbianism, female sexual self-exploration, and orgasms. The cinematic techniques of these filmmakers construct a specific view of female pleasure, emphasizing the plurality and visibility in cinema of female sexuality and desire. An interdisciplinary approach to the analysis of specific sequences suggests that the aesthetics and visual strategies of these women filmmakers evince pioneering female characters and subjectivities that challenge the traditional gaze on female bodies. Their films offer liberating representations that deconstruct the dominant basis of heteronormativity that has historically characterized Colombian narrative cinema. La luciérnaga (Hermida, 2016) y Señoritas (Rodríguez, 2013), dos películas colombianas contemporáneas realizadas por mujeres, subvierten las normas patriarcales de la narratología clásica del cine colombiano a través de su representación del lesbianismo, la autoexploración sexual femenina y los orgasmos. Las técnicas cinematográficas empleadas construyen una visión específica del placer femenino, haciendo hincapié en la pluralidad y visibilidad de la sexualidad y el deseo femenino. Un análisis de secuencias específicas con enfoque interdisciplinario sugiere que la estética y las estrategias visuales de estas cineastas evidencian personajes femeninos pioneros y subjetividades que desafían la mirada tradicional sobre los cuerpos femeninos. Las películas muestran representaciones liberadoras que deconstruyen la base heteronormativa dominante que históricamente ha caracterizado al cine narrativo colombiano.
Fatigue in advanced disease associated with palliative care: A systematic review of non-pharmacological treatments
Authors: Mochamat  , Cuhls Henning , Sellin Julia , Conrad Rupert , Radbruch Lukas , Mücke Martin 
Published: March 2021

Background: Fatigue is a common complaint reported by patients with advanced disease, impacting their daily activities and quality of life. The pathophysiology is incompletely understood, and evidence-based treatment approaches are needed. Aim: This systematic review aims to evaluate the efficacy of non-pharmacological interventions as treatment for fatigue in advanced disease. Design: The review design follows the Cochrane guidelines for systematic reviews of interventions. Data sources: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, PubMed, ClinicalTrials.gov and a selection of journals up to February 28th 2019, for randomised controlled trials (RCTs) investigating the effect of non-pharmacological treatments for fatigue in advanced disease associated with palliative care. Further potentially relevant studies were identified from the reference lists in relevant reviews, and in studies considered for this review. Results: We screened 579 publications; 15 met the inclusion criteria, with data from 1179 participants: 815 were treated with physical exercise, 309 with psycho-educational therapy and 55 with an energy restoration approach. Sources of potential bias included lack of description of blinding and allocation concealment methods, and small study sizes. Physical exercise as treatment for fatigue in patients with advanced cancer was supported by moderate-quality evidence. Conclusion: Physical exercise should be considered as a measure to reduce fatigue in patients with advanced cancer, but data on other advanced diseases is lacking. Due to the differences between studies, no clear recommendations can be made with respect to the best type of physical therapy. Restoration exercise and psycho-educational therapy are promising treatment options, although further research is needed.
Psychiatric Symptoms in Multiple Chemical Sensitivity
Authors: Simon Gregory E. 
Published: March 2021

Neuropsychiatric symptoms are among the most prominent manifestations of generalized chemical sensitivity. Patients, clinicians, and researchers are in agreement that symptoms such as depression, irritability, and mood instability are prominent among the distressing and disabling symptoms occurring in response to low-level chemical exposure. Beyond that point, however, agreement is difficult. The pathophysiology and clinical management of these symptoms remain quite controversial. This paper will review available data on the prevalence and form of psychiatric symptoms among those suffering from multiple chemical sensitivity. Various models explaining the relationship of psychiatric symptoms to chemical sensitivity will be discussed. Finally, the implications of these models for clinical management and future research will be reviewed.
Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism
Authors: Direito Bruno , Mouga Susana , Sayal Alexandre , Simões Marco , Quental Hugo , Bernardino Inês , Playle Rebecca , McNamara Rachel , Linden David EJ , Oliveira Guiomar , Castelo Branco Miguel 
Published: March 2021

Autism spectrum disorder is characterized by abnormal function in core social brain regions. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback. Following up the demonstration of neuromodulation in healthy participants, in this repeated-measure design clinical trial, 15 autism spectrum disorder patients were enrolled in a 5-session training program of real-time functional magnetic resonance imaging neurofeedback targeting facial emotion expressions processing, using the posterior superior temporal sulcus as region-of-interest. Participants were able to modulate brain activity in this region-of-interest, over multiple sessions. Moreover, we identified the relevant clinical and neural effects, as documented by whole-brain neuroimaging results and neuropsychological measures, including emotion recognition of fear, immediately after the intervention and persisting after 6 months. Neuromodulation profiles demonstrated subject-specificity for happy, sad, and neutral facial expressions, an unsurprising variable pattern in autism spectrum disorder. Modulation occurred in negative or positive directions, even for neutral faces, in line with their often-perceived ambiguity in autism spectrum disorder. Striatal regions (associated with success/failure of neuromodulation), saliency (insula/anterior cingulate cortex), and emotional control (medial prefrontal cortex) networks were recruited during neuromodulation. Recruitment of the operant learning network is consistent with participants’ engagement. Compliance, immediate intervention benefits, and their persistence after 6 months pave the way for a future Phase IIb/III, randomized controlled clinical trial, with a larger sample that will allow to conclude on clinical benefits from neurofeedback training in autism spectrum disorder (NCT02440451). Lay abstract Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits.
Short report: Patterns of US federal autism research funding during 2017–2019
Authors: Harris Lauren , Gilmore Daniel , Longo Anne , Hand Brittany N 
Published: March 2021

In 2017, the Interagency Autism Coordinating Committee, a federal advisory panel consisting of autism researchers and community members, recommended that funders of autism research prioritize research projects on: (1) treatments/interventions, (2) evidence-based services, and (3) lifespan issues. We sought to describe research funding since this recommendation was made. We searched the databases of the three largest federal funders of autism research in the United States (National Institutes of Health, Department of Education, and Centers for Disease Control and Prevention) for grants awarded during 2017–2019. We categorized grants as follows: autism screening and diagnosis, biology, risk factors, treatments and interventions, services, lifespan issues, or infrastructure and surveillance. We found that funding patterns remained largely consistent during 2017–2019. Biological research received a relative majority of funding (32.59%), followed by treatments and interventions (22.87%). While given higher funding priority by the Interagency Autism Coordinating Committee’s recent budget recommendation, fewer funds were awarded to research areas like services (5.02%) and lifespan issues (2.51%), indicating a misalignment between funding patterns and the Interagency Autism Coordinating Committee budget recommendation. These findings emphasize the need for autism research funding to align with the Interagency Autism Coordinating Committee budget recommendations to best meet the needs of the autism community, particularly autistic younger, middle-aged, and older adults. Lay abstract In 2017, an advisory board consisting of autism researchers and community members recommended that funders of autism research prioritize research projects on: (1) treatments/interventions, (2) evidence-based services, and (3) lifespan issues. To describe funding in these areas since this recommendation was made, we searched the databases of the three largest federal funders of autism research in the United States. We found that the largest portion of federal funding during 2017–2019 was awarded to research on the biology of autism (32.59%) and treatments and interventions for autism (22.87%). Less funds were awarded to research areas that are high funding priorities by the Interagency Autism Coordinating Committee budget recommendation including services (5.02%) and lifespan issues (2.51%). Our findings emphasize that autism research funding is not consistent with the Interagency Autism Coordinating Committee budget recommendation to increase funding particularly to services and lifespan issues. We recommend that funding patterns should shift to better align with these priorities so that autism research may better serve the needs of the autism community.
Clinical effectiveness of drugs in hospitalized patients with COVID-19: a systematic review and meta-analysis
Authors: Abeldaño Zuñiga Roberto Ariel , Coca Silvia Mercedes , Abeldaño Giuliana Florencia , González-Villoria Ruth Ana María 
Published: March 2021

The aim was to assess the clinical effectiveness of drugs used in hospitalized patients with COVID-19 infection. We conducted a systematic review of randomized clinical trials assessing treatment with remdesivir, chloroquine, hydroxychloroquine, lopinavir, ritonavir, dexamethasone, and convalescent plasma, for hospitalized patients with a diagnosis of SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, duration of ventilation, duration of oxygen support, duration of hospitalization, virological clearance, and severe adverse events. A total of 48 studies were retrieved from the databases. Eleven articles were finally included in the data extraction and qualitative synthesis of results. The meta-analysis suggests a benefit of dexamethasone versus standard care in the reduction of risk of mortality at day 28; and the clinical improvement at days 14 and 28 in patients treated with remdesivir. We can conclude that dexamethasone would have a better result in hospitalized patients, especially in low-resources settings. The analysis of the main treatments proposed for hospitalized patients is of vital importance to reduce mortality in low-income countries, since the COVID-19 pandemic had an economic impact worldwide with the loss of jobs and economic decline in countries with scarce resources. The reviews of this paper are available via the supplemental material section.
The benefit of exercise‐based rehabilitation programs in patients with pulmonary hypertension: a systematic review and meta‐analysis of randomized controlled trials
Authors: Yan Lu , Shi Wence , Liu Zhihong , Zhao Zhihui , Luo Qin , Zhao Qing , Jin Qi , Zhang Yi , Li Xin , Duan Anqi 
Published: March 2021

Several studies have suggested that exercise capacity and quality of life are reduced in patients with pulmonary hypertension, and exercise‐based rehabilitation can improve exercise capacity and quality of life in patients with pulmonary hypertension. The aim of this study is to assess the efficacy and safety of exercise‐based rehabilitation in patients with pulmonary hypertension through a meta‐analysis of randomized controlled trials. We searched PubMed, Embase, Medline, and the Cochrane Central Register of Controlled Trials up to November 2018. All randomized controlled trials comparing exercise capacity and quality of life between patients undergoing exercise‐based rehabilitation and those undergoing non‐exercise training were included. Data were extracted separately and independently by two investigators, and discrepancies were arbitrated by the third investigator. We used the random‐effects model to analyze the results, the GRADE to assess the risk of bias in the included studies, and I2 statistic to estimate the degree of heterogeneity. Nine randomized controlled trials are included; however, only seven randomized controlled trials were able to extract data. Including inpatients and outpatients, the total number of participants was 234, most of whom were diagnosed as pulmonary artery hypertension. The study duration ranged from 3 to 15 weeks. The mean six‐minute walking distance after exercise training was 51.94 m higher than control (27.65–76.23 m, n = 234, 7 randomized controlled trials, low quality evidence), the mean peak oxygen uptake was 2.96 ml/kg/min higher (2.49–3.43 ml/kg/min, n = 179, 4 randomized controlled trials, low‐quality evidence) than in the control group. In conclusion, our finding suggests that an exercise‐based training program positively influences exercise capacity in patients with pulmonary hypertension.
Difficult airway predictors were associated with decreased use of neuromuscular blocking agents in emergency airway management: a retrospective cohort study in Thailand
Authors: Saoraya Jutamas , Vongkulbhisal Komsanti , Kijpaisalratana Norawit , Lumlertgul Suthaporn , Musikatavorn Khrongwong , Komindr Atthasit 
Published: March 2021

Abstract
Background
It is recommended that difficult airway predictors be evaluated before emergency airway management. However, little is known about how patients with difficult airway predictors are managed in emergency departments. We aimed to explore the incidence, management and outcomes of patients with difficult airway predictors in an emergency department.

Methods
We conducted a retrospective study using intubation data collected by a prospective registry in an academic emergency department from November 2017 to October 2018. Records with complete assessment of difficult airway predictors were included. Two categories of predictors were analyzed: predicted difficult intubation by direct laryngoscopy and predicted difficult bag-mask ventilation. The former was evaluated based on difficult external appearance, mouth opening and thyromental distance, Mallampati score, obstruction, and limited neck mobility as in the mnemonic “LEMON”. The latter was evaluated based on difficult mask sealing, obstruction or obesity, absence of teeth, advanced age and reduced pulmonary compliance as in the mnemonic “MOANS”. The incidence, management and outcomes of patients with these difficult airway predictors were explored.

Results
During the study period, 220 records met the inclusion criteria. At least 1 difficult airway predictor was present in 183 (83.2%) patients; 57 (25.9%) patients had at least one LEMON feature, and 178 (80.9%) had at least one MOANS feature. Among patients with at least one difficult airway predictor, both sedation and neuromuscular blocking agents were used in 105 (57.4%) encounters, only sedation was used in 65 (35.5%) encounters, and no medication was administered in 13 (7.1%) encounters. First-pass success was accomplished in 136 (74.3%) of the patients. Compared with patients without predictors, patients with positive LEMON criteria were less likely to receive neuromuscular blocking agents (OR 0.46 (95% CI 0.24–0.87), p = 0.02) after adjusting for operator experience and device used. There were no significant differences between the two groups regarding glottic view, first-pass success, or complications. The LEMON criteria poorly predicted unsuccessful first pass and glottic view.

Conclusions
In emergency airway management, difficult airway predictors were associated with decreased use of neuromuscular blocking agents but were not associated with glottic view, first-pass success, or complications.