bluuebunny/crossref_metadata_2025_split huggingface dataset:
Downregulation of NEDD4L by EGFR Signaling Promotes the Development of Lung Adenocarcinoma
Authors: Li Guoyin , Song Zewen , Wu Changjing , Li XiaoYan , Zhao Liping , Tong Binghua , Guo Zhenni , Sun Meiqing , Zhao Jin , Zhang Huina , Jia Lintao , Li Shengqing , Wang Lei 
Published: November 2021

Abstract
Cumulative evidence indicates that the abnormal regulation of the NEDD4 family of E3-ubiquitin ligases participates in the tumorigenesis and development of cancer. However, their role in lung adenocarcinoma (LUAD) remains unclear. This study comprehensively analyzed the NEDD4 family in LUAD data sets from public databases and found only NEDD4L was associated with the overall survival of LUAD patients. Gene set enrichment analysis (GSEA) indicated that NEDD4L might be involved in the regulation of mTORC1 pathway. Both cytological and clinical assays showed that NEDD4L inhibited the activity of the mTOR signaling pathway. In vivo and in vitro experiments showed that NEDD4L could significantly inhibit the proliferation of LUAD cells. In addition, this study also found that the expression of NEDD4L was regulated by EGFR signaling. These findings firstly revealed that NEDD4L mediates an interplay between EGFR and mTOR pathways in LUAD, and suggest that NEDD4L held great potential as a novel biomarker and therapeutic target for LUAD.
Antibacterial Cotton Fabric Prepared by a “Grafting to” Strategy using a QAC Copolymer
Authors: Wang Pei , Qu JieHao , Wang Lujie , Geng Junzhao , Fu FeiYa , Liu XiangDong 
Published: November 2021

Abstract
Quaternary ammonium compounds (QACs) have outstanding antimicrobial effect, but their immobilization onto cotton fiber surfaces reminds a challenge. Herein, a QAC monomer, [2-(Methacryloyloxy) ethyl] trimethy lammonium chloride (DMC) was co-polymerized with methyl acrylate (MA) to prepare an antibacterial copolymer, poly(DMC-co-MA). To graft the copolymer with an improved grafting efficiency, cotton fabric was treated using carboxymethyl chitosan (CMC) to establish an amino-functionalized fiber surface first. This treatment allows the amidation reactions between the amino groups and the pendant ester groups in the poly(DMC-co-MA) to take place, achieving a durable QAC coating onto the fiber surfaces with remarkably antibacterial effect. Characterization results indicated that when DMC/MA monomer ratio was 100:1, the resulting copolymer endows the modified cotton fabric with antibacterial capability that inactivates all Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Even after 50 laundering cycles, more than 98.0% of the antibacterial rate could still be retained. Moreover, the wearing comfort properties such as softness, water absorption and air permeability of the finishing cotton fabrics have been insignificantly changed by comparing to the untreated cotton fabric.
Response of climate change impact on streamflow: the case of the Upper Awash sub-basin, Ethiopia
Authors: Abdulahi Salih Duri , Abate Brook , Harka Arus Edo , Husen Sead Burhan 
Published: November 2021

Abstract
This paper discusses the response of climate change impact on future streamflow availability in Upper Awash River basin, Ethiopia. The change of climate was built using the CORDEX, RCM daily precipitation, maximum and minimum temperature under RCP4.5 and 8.5 scenarios. The climate model was examined in the historical period 1996–2015 for its ability to capture observed precipitation and temperature. Bias correction was performed on RCM temperature and precipitation to minimize the uncertainties that may occur from climate model projection. After the successful calibration and validation of the HBV hydrological model, streamflow was simulated for the periods of 2021–2040 and 2041–2060 and compared to streamflow of the baseline period 1996–2015 to investigate the changes. The results suggested that overall, following the precipitation increment, streamflow is expected to increase under both RCPs. The average monthly changes of streamflow are expected to increase by 40.1 and 29.4% under RCP4.5 and 16.9 and 18.5% under RCP8.5 scenarios for 2021–2040 and 2041–2060, respectively. Annual streamflow would increase by 28.5 and 23.95% under RCP4.5 and 8.5, respectively. The results of this work can help and inform the water resources planner and designer to frame an appropriate plan and management for the effective use of water in the future.
Identifying the spatio-temporal variations of Ulva prolifera disasters in all life cycle
Authors: Zhang Baowei , Guo Jianzhong , Li Ziwei , Cheng Yi , Zhao Yao , Boota Muhammad Waseem , Zhang Yaonan , Feng Liqiang 
Published: November 2021

Abstract
Since 2007, Ulva prolifera disasters have occurred every year in the South Yellow Sea of China, the largest green tide disaster in the world. The inter-annual differences make monitoring and early warning for such disasters difficult. This study used remote sensing data (2015–2019) to determine its spatio-temporal variations in all life cycles. The results showed a lay effect between the NDVI-mean and the coverage area of U. prolifera. The spatio-temporal distribution of U. prolifera showed stages and regional differences. From late April to early May, U. prolifera first emerged near the Subei Shoal. After development in the middle of the Yellow Sea, U. prolifera broke out in the eastern sea area of Shandong and Jiangsu, declined in the Shandong sea area, and disappeared near Qingdao. The cycle lasted for approximately 90 days. The sea surface temperature was the necessary condition for the disaster, and the sea wind field was the main driving force for its horizontal drift. This study overcomes the poor timing and continuity of remote sensing data in the monitoring of U. prolifera. It provides a theoretical reference for forecasting the outbreak period of U. prolifera and can aid policy-makers to avert such disasters in advance.
Treatment of poultry slaughterhouse wastewater using electrocoagulation: a review
Authors: Ngobeni Philadelphia Vutivi , Basitere Moses , Thole Andile 
Published: November 2021

AbstractPoultry slaughterhouses are generally large consumers of fresh water, which is exhausted as wastewater characterized by a high concentration of biological oxygen demand (BOD), chemical oxygen demand COD, and fats, oil, and grease (FOG). Cost-effective methods are required for the treatment of poultry slaughterhouse wastewater, with the aim of attaining a high quality effluent that can be reused in industrial processes to promote sustainability. As compared to conventional treatment methods, electrocoagulation is an efficient and low-cost system. Electrocoagulation is environmentally friendly, treating wastewater without the need of chemicals, thus limiting secondary pollution. The metal anodes initiate electrochemical reactions for coagulation and flocculation. Its distinct advantages include compact installation and simple operation. This paper offers a comprehensive review of recent literature that has been dedicated to utilizing electrocoagulation for poultry slaughterhouse wastewater treatment. This paper also examines aspects such as theory, potential applications, current applications, as well as economical assessment of the technique.
Performance evaluation and substrate removal kinetics in a thermophilic anaerobic moving bed biofilm reactor for starch degradation
Authors: Shahzad H. M. A. , Khan S. J. , Habib Z. 
Published: November 2021

Abstract
A laboratory-scale anaerobic moving bed biofilm reactor (AnMBBR) was installed and operated at various hydraulic retention times (HRTs) of 20 to 1.5 d with surface area loading rate (SALR) of 0.86 to 11.43 gCOD/m2/d. Synthetic starch containing desizing wastewater with chemical oxygen demand (COD) of 12.75 g/L was prepared and fed into the reactor. Monod, modified Stover-Kincannon, Grau second-order and First-order substrate removal models were used to evaluate the results of AnMBBR. COD removal efficiency of bioreactor was dwindled by increasing the SALR or reducing the HRT. Decay coefficient (Kd) and yield coefficient (Y) for the Monod model were 0.027 1/d and 1.01 mgVSS/mgCOD, respectively. Maximum substrate utilization rate (Umax) and kinetic constant (Kb) for the Modified Stover-Kincannon model were estimated as 12.57 and 15.22 g/L/d, respectively. The constants (a and b) for the Grau second-order model were found to be 1.09 and 1.31 whilst kinetic coefficient for the Second-order model and First-order substrate removal model were 1.62 and 1.55 1/d, respectively. Modified Stover-Kincannon model and Grau second-order model were found to be the best fit for experimental data with R2 value of 0.99. The findings suggest that these models can be applied to predict the behaviour of AnMBBRs on various scales.
A Comprehensive Review on Medicinal Herbs and Novel Formulations for
the Prevention of Alzheimer’s Disease
Authors: Kaur Sarabjit , Singh Balbir , Singh Hasandeep , Singh Brahmjot , Kumar Navkaran , Rajput Ankita , Sidhu Disha , Kaur Amandeep , Arora Saroj 
Published: November 2021

Abstract:
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases reported
in the aging population across the globe. About 46.8 million people are reported to have dementia,
and AD is mainly responsible for dementia in aged people. Alzheimer's disease (AD) is thought
to occur due to the accumulation of β-amyloid (Aβ) in the neocortex portion of the brain, nitric
oxide mediated dysfunctioning of blood-brain barrier, reduced activity of serine racemase enzyme,
cell cycle disturbances, damage of N-methyl-D-aspartate (NMDA) receptors and glutamatergic neurotransmission.
Modern treatment methods target the pathways responsible for the disease. To
date, solely symptomatic treatments exist for this disease, all making an attempt to counterbalance
the neurotransmitter disturbance. Treatments able to prevent or at least effectively modifying the
course of AD, referred to as ‘disease-modifying’ drugs, are still under extensive research. Effective
treatments entail a better indulgence of the herbal bioactives by novel drug delivery systems. The
herbal bioactive administered by novel drug delivery systems have proved beneficial in treating
this disease. This review provides detailed information about the role of medicinal plants and their
formulations in treating Alzheimer’s disease which will be highly beneficial for the researchers
working in this area.
Discovery of Novel Antimalarial Drugs Based on Thiosemicarbazone Derivatives: An In Silico Approach
Authors: Anant Arjun , Kaur Kamalpreet , Asati Vivek 
Published: November 2021

Background:
Thiosemicarbazones belong to the group of semicarbazides, which contains a sulfur atom instead of an oxygen atom. Several studies have shown that they are effective against extracellular protozoans like Trichomonas vaginalis, Plasmodium falciparum, Trypanosoma cruzi, and other parasites.

Objective:
The current research involves pharmacophore model design, 3-D-QSAR, virtual screening, and docking studies, all of which are evaluated using various parameters.

Methods:
The present study was performed by Schrodinger software. A total of 40 ligands were selected for the development of 3D QSAR models. To predict the pIC50 values in 3D-QSAR analysis, the entire dataset was divided into two sets, training, and test sets, in a 7:3 ratio. The selected pharmacophore hypothesis has been used for the virtual screening study.

Results:
DHHRR_1 emerged as the best pharmacophore model with a survival score of 5.80. The 3D QSAR study showed a significant model with R2 = 0.91 and Q2 = 0.73. The series top-scoring compound 7e had a docking score of -10.44 and showed interactions with the amino acids, ARG-265, PHE-227, and LEU-531, required for activity. The developed pharmacophore model had been used for the screening of ZINC compounds, where ZINC26244107, ZINC13469100, ZINC01290725, and ZINC01350173 showed the best XP docking scores (-11.60, -11.27, -11.35, -10.52, respectively) while binding important amino acids ARG265, HIE185 and LEU 531 against plasmodium falciparum, PDB ID:5TBO. The docking study was further evaluated by taking standard drug chloroquine, showing similar binding interactions as shown by other compounds. The ADME studies showed the drug-likeness properties of the compounds.

Conclusion:
The results of the present study may be helpful for the future development of antimalarial compounds against Plasmodium falciparum.
A Transdiagnostic, Emotion Regulation App (Eda) for Children: Design, Development, and Lessons Learned
Authors: Moltrecht Bettina , Patalay Praveetha , Bear Holly Alice , Deighton Jessica , Edbrooke-Childs Julian 
Published: November 2021

Background
Digital interventions, including mobile apps, represent a promising means of providing effective mental health support to children and young people. Despite the increased availability of mental health apps, there is a significant gap for this age group, especially for children (aged 10-12 years). Research investigating the effectiveness and development process of child mental health apps is limited, and the field faces persistent issues in relation to low user uptake and engagement, which is assumed to be a result of limited user involvement in the design process.

Objective
This study aims to present the development and design process of a new mental health app for children that targets their emotion regulation abilities. We describe the creation of a new interdisciplinary development framework to guide the design process and explain how each activity informed different app features.

Methods
The first 2 stages of the framework used a variety of methods, including weekly classroom observations over a 6-month period (20 in total); public engagement events with the target group (N=21); synthesis of the existing evidence as part of a meta-analysis; a series of co-design and participatory workshops with young users (N=33), clinicians (N=7), researchers (N=12), app developers (N=1), and designers (N=2); and finally, testing of the first high-tech prototype (N=15).

Results
For the interdisciplinary framework, we drew on methods derived from the Medical Research Council framework for complex interventions, the patient–clinician framework, and the Druin cooperative inquiry. The classroom observations, public engagement events, and synthesis of the existing evidence informed the first key pillars of the app and wireframes. Subsequently, a series of workshops shaped and reshaped the content and app features, including games, psychoeducational films, and practice modules. On the basis of the prototype testing sessions, we made further adjustments to improve the app.

Conclusions
Although mobile apps could be highly suitable to support children’s mental health on a wider scale, there is little guidance on how these interventions could be designed and developed. The involvement of young users across different design activities is very valuable. We hope that our interdisciplinary framework and description of the used methods will be helpful to others who are hoping to develop mental health apps for children and young people.
Association of Polypharmacy with Kidney Disease Progression in Adults with CKD
Authors: Kimura Hiroshi , Tanaka Kenichi , Saito Hirotaka , Iwasaki Tsuyoshi , Oda Akira , Watanabe Shuhei , Kanno Makoto , Shimabukuro Michio , Asahi Koichi , Watanabe Tsuyoshi , Kazama Junichiro James 
Published: November 2021

Background and objective
Polypharmacy is common in patients with CKD and reportedly associated with adverse outcomes. However, its effect on kidney outcomes among patients with CKD has not been adequately elucidated. Hence, this investigation was aimed at exploring the association between polypharmacy and kidney failure requiring KRT.

Design, setting, participants, and measurements
We retrospectively examined 1117 participants (median age, 66 years; 56% male; median eGFR, 48 ml/min per 1.73 m2) enrolled in the Fukushima CKD Cohort Study to investigate the association between the number of prescribed medications and adverse outcomes such as kidney failure, all-cause mortality, and cardiovascular events in Japanese patients with nondialysis-dependent CKD. Polypharmacy and hyperpolypharmacy were defined as the regular use of 5–9 and ≥10 medications per day, respectively.

Results
The median number of medications was eight; the prevalence of polypharmacy and hyperpolypharmacy was each 38%. During the observation period (median, 4.8 years), 120 developed kidney failure, 153 developed cardiovascular events, and 109 died. Compared with the use of fewer than five medications, adjusted hazard ratios (95% confidence intervals) associated with polypharmacy and hyperpolypharmacy were 2.28 (1.00 to 5.21) and 2.83 (1.21 to 6.66) for kidney failure, 1.60 (0.85 to 3.04) and 3.02 (1.59 to 5.74) for cardiovascular events, and 1.25 (0.62 to 2.53) and 2.80 (1.41 to 5.54) for all-cause mortality.

Conclusions
The use of a high number of medications was associated with a high risk of kidney failure, cardiovascular events, and all-cause mortality in Japanese patients with nondialysis-dependent CKD under nephrology care.
Noninvasive Diagnosis of PLA2R-Associated Membranous Nephropathy
Authors: Bobart Shane A. , Han Heedeok , Tehranian Shahrzad , De Vriese An S. , Roman Juan Carlos Leon , Sethi Sanjeev , Zand Ladan , Andrades Gomez Cristina , Giesen Callen D. , Soler Maria Jose , Bomback Andrew S. , Fervenza Fernando C. 
Published: November 2021

Background and objectives
Kidney biopsy is the current gold standard to diagnose membranous nephropathy. Approximately 70%–80% of patients with primary membranous nephropathy have circulating anti-phospholipase A2 receptor antibodies. We previously demonstrated that in proteinuric patients with preserved eGFR and absence of associated conditions (e.g., autoimmunity, malignancy, infection, drugs, and paraproteinemia), a positive anti-phospholipase A2 receptor antibody test by ELISA and immunofluorescence assay confirms the diagnosis of membranous nephropathy noninvasively. These data have not been externally validated.

Design, setting, participants, & measurements
The clinical and pathologic characteristics of patients with a positive anti-phospholipase A2 receptor antibody test at the Mayo Clinic, the University Hospital Vall D’Hebron (Barcelona), and the Columbia University Medical Center (New York) were retrospectively reviewed. Biopsy findings and presence or absence of a potential associated condition were assessed.

Results
From a total of 276 patients with positive anti-phospholipase A2 receptor serology, previously reported patients (n=33), kidney transplant recipients (n=9), pediatric patients (n=2), and patients without kidney biopsy (n=69) were excluded. Among the 163 remaining patients, associated conditions were identified in 47 patients, and 15 patients had diabetes mellitus. All 101 patients of the final cohort had a primary diagnosis of membranous nephropathy on kidney biopsy. In the 79 patients with eGFR≥60 ml/min per 1.73 m2, none of the biopsy findings altered diagnosis or management. Among the 22 patients with decreased eGFR, additional findings included superimposed acute interstitial nephritis (n=1).

Conclusions
In patients with preserved eGFR and absence of associated conditions or diabetes, a positive anti-phospholipase A2 receptor test by either ELISA >20 RU/ml or a positive immunofluorescence assay confirms the diagnosis of membranous nephropathy, precluding the requirement for a kidney biopsy.
Entre Lima y México. Palabras para Ricardo Melgar, In memoriam
Authors: Candia José Miguel 
Published: November 2021

¿Qué vectores determinan nuestra vida de relación? ¿El azar, una voluntad ajena o los caprichos de la suerte? Quizá todo eso y otros factores que escapan al pretendido rigor de las agendas. Lo cierto es que a principios de 1976, buena parte de la izquierda sudamericana enfrentaba una opción extrema: abandonar el país de origen en las condiciones que se pudiera y salvar la vida o afrontar en la clandestinidad el avance de las fuerzas represivas. Las condiciones políticas de Argentina, Uruguay, Chile, Bolivia, Paraguay y Brasil eran de horror. Con matices, la situación de Perú, bajo el mandato del general Morales Bermúdez, mostraba un panorama menos degradado pero que se fue descomponiendo poco después de nuestra llegada a Lima. De esa forma y en condiciones precarias, un grupo de exiliados argentinos nos instalamos en Perú. No parecía tan grave lo que habíamos decidido; con cierta ingenuidad y buen ánimo, esperábamos que en un par de años la dictadura argentina se derrumbara. Lo que seguía era un retorno triunfal a Buenos Aires en cuatro horas de vuelo. Poca cosa, si se piensa en una época cargada de épica militante y horizontes maximalistas.
Samarbeid mellom kulturskolelærer og grunnskolelærer – utfordringer og muligheter
Authors: Hauge Kåre 
Published: November 2021

The purpose of this study has been to try to capture tensions and contradictions in the project «culture day in school», a collaborative project between cultural school and primary school. In addition, it has been an intention to try to understand and analyze the tensions and contradictions. The research question addressed in the article is: How is the collaboration between cultural school teacher and primary school teacher organized and implemented in the project culture day in school, and what tensions and contradictions can be discovered in this collaboration towards common goals / intention.
Previous studies of collaboration between cultural schools and primary schools show that there are challenges associated with such collaborations, especially with regard to how such collaborative projects are operationalized. One of the main arguments for the study is to increase the understanding and knowledge of how such collaborations can be improved and developed.
In this study, I have interviewed a cultural school teacher and an elementary school teacher. In addition, the project’s goals and intentions have been used as a guiding guide to see how the collaborative project works towards these.
The study shows that there are several tensions and contradictions that are revealed, and that several of these have not come to the surface and been addressed by the participants in the collaboration. The study also shows that there is a need for practitioners who are to carry out collaborative projects to a much greater extent to be involved in all processes, from planning to evaluation.