bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature-dependent elastic, mechanical, thermal, and acoustic behavior in alkaline earth semiconductors
Authors: Chauhan Jyotsana , Singh Devraj , Khenata Rabah , Meradji Hocine , Bin-Omran Saad , Maddheshiya Ajit Kumar 
Published: January 2025

Abstract
This study investigates the temperature-dependent elastic, mechanical, thermal, and acoustic features of alkaline earth semiconductors calcium monochalcogenides CaX (X = S, Se, Te). First of all, the second- and third-order elastic constants have been calculated in the temperature range 0–500 K using the Born-potential model. The evaluated SOECs values were utilized to compute the mechanical constants at 0 K and 300 K. Selected materials in the present investigation have been found mechanically stable and brittle, in nature. The elastic anisotropy of the mechanical moduli has been presented using the 3D surface. SOECs have also been employed to perceive the acoustical wave velocities for longitudinal and shear modes of propagation and Debye mean velocities along <100>, <110>, and <111> directions. SOECs and TOECs were used to calculate the acoustic Grüneisen parameters. Further, the Debye characteristic temperature, thermal conductivity, specific heat, and energy density were computed for CaX. Finally, the direction-dependent ultrasonic attenuation due to phonon–phonon interaction and thermelastic relaxation process has been computed for CaX at room temperature. The results obtained have been validated with existing results that are accessible for the chosen materials.
Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men
Authors: Guedes Jéssica , Pla Indira , Sanchez Aniel , Marko-Varga Gyorgy , Domont Gilberto Barbosa , Sahlin K Barbara , Hazir Berk , Giwercman Aleksander , Sousa Nogueira Fábio César , Malm Johan , Lundberg Giwercman Yvonne 
Published: January 2025

BackgroundProstate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unclear and difficult to disentangle from that of androgens. In this study, we examined the metabolic changes induced by FSH and distinguished them from those caused by testosterone.MethodsPlasma samples from temporarily medically castrated young men (n = 33) treated with FSH and/or testosterone were characterized by proteomics and metabolomics approaches. All subjects received GnRH antagonists. Sixteen men were randomized to recombinant FSH (300 IU 3 times/week) for 5 weeks, while seventeen men served as controls. After 3 weeks, all men received 1000 mg intramuscular testosterone undecanoate. Blood samples were collected at the start, after 3 weeks and after 5 weeks. The proteome and metabolome signatures were characterized in all samples.ResultsFSH significantly upregulates key proteins involved in the modulation of inflammatory response and innate immune system (P ≤ 0.03) and dysregulates lipid metabolism, evidenced by downregulation of multiple apolipoproteins (P ≤ 0.04) and increased levels of cholesterol and glycerophospholipids (P ≤ 0.03). In addition, low FSH levels were correlated with a reduction in the active form of vitamin D (P < 0.02). These results highlight the short-term metabolic impacts of FSH in males.Conclusions and Clinical ImplicationsOur findings underlined the FSH effect on extragonadal systems and its connection to metabolic disorders often seen as secondary effects of prostate cancer treatment.
Organização da Revista
Authors: Amigos da Natureza ANAP - 
Published: January 2025

ORGANIZAÇÃO ANAP – Associação Amigos da Natureza da Alta Paulista CONSELHO ADMINISTRATIVO Allan Leon Casemiro dos SantosAna Paula Miranda dos SantosSandra Medina Benini CONSELHO EDITORIAL Allan Leon Casemiro dos SantosAna Paula Miranda dos SantosElisângela Medina BeniniLeonice Seolin DiasMaria Betânia Moreira AmadorSandra Medina Benini E-MAIL DE CONTATO anapbrasil@amigosdanatureza.org.br
Archival Certification Is One Piece of the Professionalization Puzzle
Authors: Dominick Emily Hughes , Flynn Rosemary Pleva , Oestreicher Cheryl , Sternberger Katy , Sly Margery N. , Linn Mott , Schaad Gerrianne , Baker Dara 
Published: January 2025

ABSTRACT
In response to Ashley Todd-Diaz and Alex H. Poole's 2022 article published in American Archivist, “Who Is This Godot? The Academy of Certified Archivists and Graduate Archival Education,” the Academy of Certified Archivists (ACA) affirms the continuing relevance of archival certification and its place in the profession. ACA outlines its ongoing work to engage members, support graduate archival education, and further the discussion surrounding professionalization of the archives field. Based on themes that arose from ACA board discussions and a member forum, the authors discuss how certification complements graduate education; address how ACA values collaboration; explain how the certification examination is a valid and reliable measure of archival knowledge; consider how certification is a personal and professional investment; and affirm that certification is a worthwhile and relevant credential that enhances archivists and the profession.
MASLD-Induced Liver Micro-Organoids Mimics Clinical Observations of Impaired Vitamin D Synthesis
Authors: Hammour Mohammad Majd , Chen Guanqiao , Xin Yuxuan , Damm Georg , Vosough Massoud , Kaufmann Benedikt , Nussler Andreas Klaus , Aspera-Werz Romina Haydeé 
Published: January 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern associated with various metabolic disorders and a high prevalence of vitamin D deficiency. Current animal models face limitations in accurately mimicking human metabolic pathways and are constrained by ethical considerations. This study aimed to develop an in vitro MASLD-induced liver micro-organoid model to investigate the impact of MASLD on vitamin D metabolism. The model incorporates HepaRG cells as hepatocytes, LX-2 cells as stellate cells, and human umbilical vein endothelial cells (HUVECs). Fatty liver characteristics were induced by treating the micro-organoids with palmitic/oleic acids. fatty acid accumulation was quantified and visualized using Bodipy staining. The expression of genes involved in drug and vitamin D metabolism was evaluated by RT-PCR. Dot blot analysis assessed secreted proteins indicative of liver damage. ELISA was used to examine vitamin D metabolism. The results confirmed the successful induction of MASLD, evidenced by altered cytochrome P450 gene expression, elevated markers of liver damage, and reduced vitamin D metabolism. These findings align with clinical studies and RNA-sequencing data from liver biopsies of MASLD patients. This innovative micro-organoid platform offers a robust tool for studying the molecular mechanisms of MASLD and represents a promising alternative to animal experiments.
Social Ownership and Restitution of Agricultural Land in Croatia
Authors: Ernst Hano , Josipović Tatjana 
Published: January 2025

This paper discusses the state of agricultural land in Croatia from a historical perspective. It first discusses the genesis and development of collectivisation of agricultural land in Croatia after the Second World War, particularly with reference to the idiosyncrasies of Yugoslav socialist property as compared to traditional Soviet doctrines. The developments are characterised by gradual changes in legal status as reflections of changing ideologies and policies during the socialist period concerning self-management, as well as sectoral developments (cooperative and industrial sectors). The paper goes on to analyse the transformation of social ownership over agricultural land, both in terms of its direct transformation into state ownership, as well as its in-kind restitution to former rights-holders or their descendants, particularly referencing the causes and consequences of various problems in achieving initial privatisation goals. The paper finally draws conclusions on the current state of agricultural land policies and its prospects.
Constitutional and Legal Aspects of the Processes of (De)nationalisation and Privatisation of land and of state-owned enterprises – Macedonian examples of controversial politicisation and elitisation
Authors: Karakamisheva-Jovanovska Tanja 
Published: January 2025

The process of transition from former socialist to democratic systems brought to surface numerous questions about the political, legal, economic, social and cultural transformation in the societies in which these systems existed. With the fall of the Berlin wall and the so-called Iron Curtain, the former socialist states faced numerous challenges in dealing with the unfair nationalisation of citizens’ private property, dilemmas on how to apply a denationalisation process that will be fair and just, and which model of privatisation of state-owned capital to apply, having in mind the experience of the more advanced western democracies. The key issues in this context were: which type of market economy to choose, how fast should the transition be implemented and through which methods; the answers to these questions differed from country to country, because the transition, just as in a game of chess, does not have a winning formula, but offers merely a limited set of general rules of behaviour. The quest for an intellectually perfect concept of transition that would cover all possible scenarios and details would mean indefinite delay in its application. However, the lack of a coherent and clear strategy also generates serious social and economic problems. This is what the transfer from a planned and politically monolithic economy to a pluralistic and market-oriented economy has done in the countries of Central, Eastern and Southeast Europe, leaving behind a number of open issues and dilemmas. On the other hand, certain governments which captured the state institutions and did not set any boundaries between the party (personal) interests and the state interests, caused additional political turbulence. Partisan domination in the public/state administration had a strong effect on the ongoing privatisation processes, because business and the party in power were always on the same side of the coin. The high degree of political control over state resources created fertile ground for the emergence of political elites which entirely usurped the national economic potential of the given countries. Unlike the Central and East European countries, which successfully completed their denationalisation processes, the number of incomplete denationalisation cases in Macedonia is devastating. This paper will focus on the Macedonian transition under the influence of the transition processes in the region and will reveal a number of specific features of the Macedonian model. It will show the connection between the captured state and the privatisation of state capital. This connection results in a strong influx of private capital in the hands of the political elite through dubious processes of state capital privatisation, thus generating sources of corruption, clientelism, elitism, technocraticism and other similar processes that reflect the political power in a captured state.
Restitution of Nationalised or Collectivised Agricultural Lands and Forests – Bosnia and Herzegovina, Lost in Transition
Authors: Povlakić Meliha 
Published: January 2025

In the former Socialist Republic of Bosnia and Herzegovina (hereafter: SRBH) agricultural and forest land, as important natural resources of any economy, were the subject of double restrictions. One was a result of the social attachment of property, and is immanent not only to socialistic regimes. The other restriction was the result of socialist ideology, which meant that these important economic resources could only to a limited extent be privately owned — and that everything beyond prescribed limits was nationalised. There was also a vast range of other reasons for the nationalisation of these goods. The transformation process entailed the removal of restrictions on the extent of ownership of these properties, and this was done within the framework of the constitutional reforms in the former Yugoslavia (1989/90). Still in the SRBH, after these constitutional reforms it was clear that denationalisation and restitution should follow. In 1991 it was forbidden by law to dispose of nationalised property. The measures of denationalisation and restitution of nationalised property are the focus of this article. First, a short analysis is given of the history of nationalisation and confiscation of property in the former Yugoslavia after the World War II. Since the end of the 20th Century (1995), Bosnia and Herzegovina (BH) has been an independent state which has performed crucial reforms within the process of transformation. But the denationalisation measures regarding agricultural and forest land are still pending. One of the reasons for that is the fact that BH is composed of three separate legal orders: Federation of Bosnia and Herzegovina, Republic of Srpska and Brčko District of BH. All three legal orders have been thoroughly analysed, since the legislative competencies for regulating denationalisation are merely given to these constituent parts of BH. Due to the political tensions and problems, it is unlikely that a framework law will be passed. The unclear ownership of agricultural and forest land (no criterion for the division of state ownership has yet been established) led to the OHR imposing a ban on the disposal of these assets in 2022. The consequence of the long absence of restitution and the coexistence of two restraining orders, which have different reasons and follow different goals, is a lack of legal certainty. The article concludes that in Bosnia and Herzegovina the final implementation of the transformation process in general, and restitution as a part of it, still faces many obstacles — lack of legal basis, facts established during the war, processes that are not centralised and coordinated due to the state structure, adoption of legal solutions that may jeopardise restitution in general, and restitution of agricultural land and forests as well. In brief: Bosnia and Herzegovina is still lost in transition.
SHMT2 arginine methylation by PRMT1 facilitates esophageal cancer progression by enhancing glycolysis and one-carbon metabolism
Authors: Xu Zhengshui , Ye Changchun , Cheng Yao , Zhao Feng , Li Jianzhong , Jiang Jiantao , Liu Shiyuan 
Published: January 2025

Abstract

Background
Protein arginine methyltransferase 1 (PRMT1) is the main enzyme that directly responsible for the production of asymmetric dimethylarginine (ADMA), and upregulation of PRMT1 is observed in a variety of malignancies, including esophageal cancer (ESCA). Dysregulation of arginine methylation caused by PRMT1 overexpression is a driver of poor cancer progression, and the detailed mechanism of modulation is currently unknown.
Results
The present study confirmed a novel oncogenic mechanism of PRMT1 in ESCA. PRMT1 levels were significantly upregulated in ESCA, and its high expression correlated with TNM stage and poor patient prognosis. We continued to find the mechanisms by which PRMT1 expression was more relevant to ESCA progression. RNA-seq and KEGG enrichment analyses revealed that differentially expressed genes after PRMT1 silencing in ESCA might modulate serine/one-carbon metabolism. Knockdown of PRMT1 in vitro resulted in a significant reduction in ESCA cell growth, and indicators related to serine/one-carbon metabolism and glycolysis, whereas its overexpression showed opposite results. The catalytic activity of PRMT1 was crucial in mediating these biological processes. We found that PRMT1 mediated the ADMA modification of serine hydroxymethyltransferase 2 (SHMT2) at arginine 415 (R415), which activated SHMT2 activity and enhanced serine/one-carbon metabolism and glycolysis. The R415K mutation largely eliminated the arginine methylation of SHMT2 by PRMT1, and weakened PRMT1-induced glycolysis and serine/one-carbon metabolism.
Conclusion
Our study further confirmed the link between the two proteins, PRMT1 and SHMT2, as well as arginine methylation and glycolysis. The study of deeper molecular mechanisms will reveal a broader role of arginine methylation in the regulation of glycolysis.
WITHDRAWN: Comparison of Upper Arm Ports and Peripherally Inserted Central Catheters in Patients with Nasopharyngeal Carcinoma: A Randomized Controlled Trial.
Authors: Xiao Maofang , Li Jia , Xiao Caiqiong , Hu Wen , Fan Yuying , Qin Huiying 
Published: January 2025

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: Development and Validation of a Pathomics Model for Accurate Grading of Pancreatic Neuroendocrine Tumors Short title: Pathomics Model for Grading of PNETs
Authors: ying li , Chen Chengwei , Zhang Yunshuo , Yu Jieyu , Fang Xu , Liu Fang , Wang Tiegong , Li Jing , Wang Li , Lu Jianping , Jiang Hui , Shao Chengwei , Bian Yun 
Published: January 2025

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Comparing the Performance of OvaCyte and Traditional Techniques in Detecting Canine Gastrointestinal Parasites
Authors: Elghryani Nagwa , McAloon Conor G. , lahan Geetika , McOwan Trish , de Waal Theo 
Published: January 2025

Abstract

Background Companion animals are infected with a range of helminth and protozoan parasites which can have a significant effect on the health and welfare of animals. While several diagnostic techniques are available to detect parasitic infection in animals, they all vary in sensitivity and specificity. This study aims to estimate the diagnostic performance of the OvaCyteTM Pet Analyser by comparing it with established benchmarks commonly used in reference laboratories.
Methods A total of 141 canine faecal samples, containing at least one species of parasite after screening using double centrifugation, were tested using 4 index tests: centrifugal flotation (faeces weighing both 1 g and 2 g), passive flotation, and the OvaCyteTM technique. The true status of each sample was determined on the basis of the initial screening test and the aggregated result of the 4 index tests. Sensitivity and specificity were calculated for each of the 4 index tests.
Results The OvaCyteTM Pet Analyser displayed high sensitivity ranging from 90% to 100% in detecting various parasite species in canines. Its sensitivity for roundworm and hookworm detection differed significantly from centrifugal flotation using 1 g and passive flotation techniques (P < 0.05). The OvaCyte™ demonstrated higher sensitivity and specificity (100%) compared to all flotation techniques (centrifuged or not) in detecting Cystoisospora spp. and Capillaria spp. (P < 0.001).
Conclusion These results highlight the variability in sensitivity across different diagnostic methods, underscoring the importance of selecting the most reliable technique for accurate parasite detection in veterinary practice. However, the OvaCyteTM Pet Analyser exhibits an elevated level of sensitivity compared to other techniques.
Intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin in colorectal cancer：a prospective, randomized, controlled, multicenter study
Authors: S Hao , Zhan Rui , L Yunfeng , L Yanke , Pe Wei , Ji Zhigang , Li Zhimin , Huan Meijin , Zhuan Jing , Jian Qian , Xi Ming , Wan Guiying , Zhan Wenbin , Li Ming , Che Jiansi , Wan Zejun , Wan Kang , Zhan Xinghong , L Guoxin , Zen Xiangfu , L Xinxiang , Su Xuejun , Wan Ju , Zen Dongzhu , Zhuan Changlong , Zho Haitao , Wan Xishan 
Published: January 2025

Abstract

Background
Peritoneal metastases (PM) after radical surgery is an important reason for the treatment failure in colorectal cancer (CRC). The intraoperatively intraperitoneal perfusion chemotherapy may be an effective method to prevent postoperative PM of CRC. We aimed to explore the safety and feasibility of intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin for CRC.
Methods
Between December 12, 2017 and October 17, 2019, 720 eligible CRC patients of which the clinical TNM stage was T4 or N + were recruited from 25 hospitals in China. Eligible patients were randomized in a 1:1 ratio to resection of CRC only (control group) or to resection of CRC with intraperitoneal perfusion chemotherapy with lobaplatin intraoperatively (lobaplatin group). The primary end point of this trial was the rate of PM after surgery; secondary end points included safety, overall survival (OS) time, progression free survival (PFS) time, peritoneal metastases recurrence free survival (PRFS) time, and the rate of liver metastasis.
Results
Of 716 patients included in the full analysis set (FAS), 352 cases were assigned in the lobaplatin group and 364 cases in the control group. For FAS population, adding intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin decreased the primary end point of the rate of PM (3.56% vs 8.75%), and the second end points of the rate of liver metastasis (5.81% vs 11.70%). There was no statistically significant difference in the 3-year OS between the groups (93.2% vs 90.4%). The 3-year PFS rate (88.1% vs 81.6%) and 3-year PRFS rate (96.6% vs 91.5%) were significantly higher in the lobaplatin group than the control group. There were no statistically significant differences between the two groups for the incidence (69.77% vs 64.75%) and severity of adverse events (AEs) for safety set (SS) population.
Conclusions
Initiation of the intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin in CRC patients had the tendency to reduces peritoneal seeding and liver metastasis in CRC and showed a trend towards prolonged PFS and PRFS. Treatment was well tolerated, and there were no increased safety findings.
Trial registration:
Chinese Clinical Trial Registry, ChiCTR1800014617
Prostatic surgery with preservation of the supramonticular tissue versus standard surgery in benign prostatic hyperplasia: a systematic review
Authors: Chuctaya Giuston Mendoza , Ramos Kevin Rodrigo , Centeno Lucely Aycachi , Rondan Alvaro Taype 
Published: January 2025

Abstract

Objective: To compare modified surgery with supramonticular tissue preservation versus standard prostate surgery.
Methods: For this systematic review, we conducted searches in PubMed, Scopus, Web of Science, and Cochrane Library. Randomized controlled trials (RCTs) and quasi-experimental studies that compared modified surgery with standard surgery were included. Two reviewers independently selected the studies. Meta-analyses were performed using RevMan 5.4, and the GRADE approach was used to assess the certainty of the evidence.
Results: We identified six studies (three RCTs and three quasi-experimental) with 336 participants. The meta-analyses showed that the modified technique may result in greater preservation of antegrade ejaculation (OR=3.12; 95% CI: 2.31 to 4.20) and may increase post-micturition residual volume (OR=4.54; 95% CI: -20.83 to 29.91). Additionally, it may have no effect on IPSS, maximum flow, and QoL. However, all these results had very low certainty of evidence.
Conclusion: In patients undergoing endoscopic surgery for BPH, surgery performed with the modified technique (preserving supramonticular tissue 1 cm above the verum montanum) may result in increased preservation of antegrade ejaculation, may increase post-micturition residual volume, and may have no effect on IPSS, maximum flow, and QoL. However, the evidence for these effects is very uncertain.