bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-functionalization, a Promising Adaptation to Overcome Challenges to Clinical Translation of Nanomedicines as Nano-diagnostics and Nano-therapeutics for Breast Cancer
Authors: Moti Lama A. Abdul , Hussain Zahid , Thu Hnin E. , Khan Shahzeb , Sohail Mohammad , Sarfraz Rai M. 
Published: September 2021

Background:
Breast cancer (BC) is one of the most aggressive and prevalent types of cancer, which
is associated with a high rate of mortality and colossal potential of metastasis to other body organs. Conventionally,
there are three commonly employed strategies for the treatment of BC including, surgery, radiations and
chemotherapy; however, these modalities are associated with several deleterious effects and a high rate of relapse.

Objective:
This review was aimed to critically discuss and conceptualize existing evidences related to the pharmaceutical
significance and therapeutic feasibility of multi-functionalization of nanomedicines for early diagnosis
and efficient treatment of BC.

Results:
Though the implication of nanotechnology-based modalities has revolutionised the outcomes of diagnosis
and treatment of BC; however, the clinical translation of these nanomedicines is facing grandeur challenges.
These challenges include recognition by the reticuloendothelial system (RES), short plasma half-life,
non-specific accumulation in the non-cancerous cells, and expulsion of the drug(s) by the efflux pump. To circumvent
these challenges, various adaptations such as PEGylation, conjugation of targeting ligand(s), and siteresponsive
behaviour (i.e., pH-responsiveness, biochemical, or thermal-responsiveness) have been adapted.
Similarly, multi-functionalization of nanomedicines has emerged as an exceptional strategy to improve the pharmacokinetic
profile, specific targetability to the tumor microenvironment (active targeting) and efficient internalization,
and to alleviate the expulsion of internalized drug contents by silencing-off efflux pump.

Conclusion:
Critical analysis of the available evidences revealed that multi-functionalization of nanomedicines
is a plausible and sustainable adaptation for early diagnosis and treatment of BC with better therapeutic outcomes.
Carpal Tunnel Syndrome in Diabetes Mellitus
Authors: Papanas Nikolaos , Stamatiou Iliana , Papachristou Stella 
Published: September 2021

Abstract:
The aim of the present brief review was to discuss carpal tunnel syndrome (CTS) in diabetes
mellitus (DM). Generally, CTS is more common in DM, especially in subjects with coexisting
diabetic polyneuropathy (DPN) and/or long DM duration. There is no agreement if it is more
frequent in type 1 or type 2 DM. The precise underlying mechanisms are not entirely clear but appear
to involve hyperglycaemia-induced median nerve oedema, increased sensitivity to exogenous
trauma and nerve myelin ischaemia and axonal degeneration. More recently, increased vascular endothelial
growth factor (VEGF) and advanced glycation endproducts (AGEs) appear to also play
an important role. Median nerve conduction study remains the cornerstone of CTS diagnosis in
DM, being more sensitive than clinical examination. CTS can be treated medically or surgically.
The latter appears now to be equally effective in subjects with vs. without DM in terms of recurrence
rates and quality of life.
LED Colour Trap for Aedes aegypti Control
Authors: Salles Tiago , Corrêa Ivo , Guimarães-Ribeiro Victor , Carvalho Edimilson , Moreira Mônica 
Published: September 2021

Background:
Aedes aegypti mosquitoes transmit dengue, zika, and
chikungunya viruses, neglected diseases that are considered global health challenges.
Due to the lack of antiviral drugs and vaccines for these illnesses, vector
control with chemical insecticides is the principal strategy for preventing their
spread. However, vector populations are becoming increasingly resistant to insecticides,
and the development of other control measures is, therefore, imperative.

Methods:
A new insect trap (IT) was used to control Aedes aegypti. A specific
light-emitting diode (LED) served as the attractant based on specific wavelength
ranges (450-495, 500-550 and 570-600 nm). The IT utilized insect-attracting and
killing mechanisms that included a black capture box, a suction-producing mechanism,
an electric shock device and a nylon cloth device that held surviving
mosquitoes, which died due to starvation. Capture assays of twenty non-feeding
females inside a cage were performed in triplicate using different LED intensities.
A commercial trap (ultraviolet lamp attractant and suction system) was used
as a positive control.

Results:
Capture assays of A. aegypti with different intensities and LED combinations
showed that the tricolored trap captured 100% of the females, followed by
the Green LED 8 set, which captured 91%; in comparison, commercial traps captured
approximately 25% of the insects. Although there were no significant differences
between the experimental groups, the tricolored trap probably will capture
more mosquito females considering the vision variation in individual females.

Conclusion:
We herein present a green technology-based IT that is effective,
safe and successful for reducing mosquito populations, thereby preventing
mosquito-borne disease spread.
An Online Assessment to Evaluate the Role of Cognitive Biases and Emotion Regulation Strategies for Mental Health During the COVID-19 Lockdown of 2020: Structural Equation Modeling Study
Authors: Blanco Ivan , Boemo Teresa , Sanchez-Lopez Alvaro 
Published: September 2021

Background
Extant research supports causal roles of cognitive biases in stress regulation under experimental conditions. However, their contribution to psychological adjustment in the face of ecological major stressors has been largely unstudied.

Objective
We developed a novel online method for the ecological examination of attention and interpretation biases during major stress (ie, the COVID-19 lockdown in March/April 2020) and tested their relations with the use of emotion regulation strategies (ie, reappraisal and rumination) to account for individual differences in psychological adjustment to major COVID-19–related stressors (ie, low depression and anxiety, and high well-being and resilience).

Methods
Participants completed an online protocol evaluating the psychological impact of COVID-19–related stressors and the use of emotion regulation strategies in response to them, during the initial weeks of the lockdown of March/April 2020. They also completed a new online cognitive task designed to remotely assess attention and interpretation biases for negative information. The psychometric properties of the online cognitive bias assessments were very good, supporting their feasibility for ecological evaluation.

Results
Structural equation models showed that negative interpretation bias was a direct predictor of worst psychological adjustment (higher depression and anxiety, and lower well-being and resilience; χ29=7.57; root mean square error of approximation=0.000). Further, rumination mediated the influence of interpretation bias in anxiety (P=.045; 95% CI 0.03-3.25) and resilience (P=.001; 95% CI −6.34 to −1.65), whereas reappraisal acted as a mediator of the influence of both attention (P=.047; 95% CI −38.71 to −0.16) and interpretation biases (P=.04; 95% CI −5.25 to −0.12) in well-being.

Conclusions
This research highlights the relevance of individual processes of attention and interpretation during periods of adversity and identifies modifiable protective factors that can be targeted through online interventions.
Thực nghiệm ương ấu trùng cua biển (Scylla paramamosain) với các quy trình khác nhau
Authors: Bác Nguyẽn Viẹt , Út Vũ Ngọc 
Published: September 2021

Nghiên cứu nhằm xác định quy trình ương thích hợp cho tăng trưởng, tỷ lệ sống và biến thái của ấu trùng cua biển. Thí nghiệm gồm 3 nghiệm thức: (1) ương ấu trùng theo quy trình sử dụng hóa chất; (2) ương ấu trùng theo quy trình sử dụng ozone; (3) ương ấu trùng theo quy trình sử dụng kháng sinh. Ấu trùng được bố trí trong bể 1,6 m3 với mật độ 200 con/L và độ mặn 30 ‰. Kết quả thí nghiệm cho thấy mật độ vi khuẩn tổng, Vibrio spp và tỷ lệ nhiễm ký sinh trùng trên ấu trùng thấp nhất ở nghiệm thức sử dụng ozone lần lượt là 0,86 x 104 cfu/mL, 0,16 x 104 cfu/mL và 6,40% khác biệt có ý nghĩa (p<0,05) với các nghiệm thức còn lại. Chỉ số biến thái, tăng trưởng về chiều dài của ấu trùng qua các giai đoạn ở nghiệm thức sử dụng ozone cao hơn (p<0,05) so với nghiệm thức sử dụng hóa chất. Tỷ lệ sống đến giai đoạn Cua 1 cao nhất ở nghiệm thức sử dụng ozone (8,81%) khác biệt không có ý nghĩa (p>0,05) với nghiệm thức sử dụng kháng sinh (7,23%), nhưng khác biệt có ý nghĩa (p<0,05) với nghiệm thức sử dụng hóa chất (2,29%). Tương tự, tỷ suất lợi nhuận cao nhất ở nghiệm thức sử dụng ozone (1,35) khác biệt không có ý nghĩa (p>0,05) với nghiệm thức sử dụng kháng sinh (0,85),...
Hiện trạng khai thác và nguồn lợi ốc cà na (Tomlinia frausseni Thach, 2014) khu vực biển ven bờ tỉnh Trà Vinh
Authors: Trần Văn Tiến , Thảo Ngô Thị Thu , Lê Thị Cẩm Hà , Nguyễn Văn Tú 
Published: September 2021

Tomlinia frausseni Thach, 2014 - ốc Cà na, loài có giá trị làm thực phẩm, phân bố chủ yếu ở khu vực vùng ven biển Đồng bằng sông Cửu Long. Nghiên cứu hiện trạng khai thác ốc Cà na khu vực biển ven bờ tỉnh Trà Vinh được thực hiện từ tháng 3 đến tháng 8 năm 2018 thông qua phỏng vấn trực tiếp 42 ngư dân về khía cạnh kỹ thuật, khía cạnh tài chính và những khó khăn, thuận lợi. Nguồn lợi ốc Cà na được ước tính dựa trên phương pháp Sản lượng-Cường lực khai thác (Catch–Effort methods) trong khoảng thời gian từ 12 tháng 5 đến 19 tháng 9 năm 2019. Kết quả cho thấy nghề khai thác ốc bắt đầu từ năm 2011, mùa vụ khai thác từ tháng 3 đến tháng 10 âm lịch, và khu vực khai thác chính tại vùng biển ven bờ. Phương thức khai thác chủ yếu là sử dụng bẫy lồng với công suất tàu trung bình 31,36 ± 2,23 CV và trọng tải trung bình 2,85 ± 0,13 tấn/tàu. Sản lượng khai thác trung bình năm đạt 6.432,74 ± 207,98 kg. Tổng chi phí trung bình cho một chuyến đi biển 1,33 ± 0,03 triệu đồng và tổng doanh thu 1,87 ± 0,10 triệu đồng. Tỉ suất lợi nhuận của nghề là 0,40 ± 0,07 triệu đồng cho một chuyến biển. Nguồn lợi ốc Cà na vùng biển ven bờ tỉnh Trà Vinh là 73.904 ± 6.684 kg...
Flood Mapping in the Coastal Region of Bangladesh Using Sentinel-1 SAR Images: A Case Study of Super Cyclone Amphan
Authors: Chakma Pollen , Akter Aysha 
Published: September 2021

Floods are triggered by water overflow into drylands from several sources, including rivers, lakes, oceans, or heavy rainfall. Near real-time (NRT) flood mapping plays an important role in taking strategic measures to reduce flood damage after a flood event. There are many satellite imagery based remote sensing techniques that are widely used to generate flood maps. Synthetic aperture radar (SAR) images have proven to be more effective in flood mapping due to its high spatial resolution and cloud penetration capacity. This case study is focused on the super cyclone, commonly known as Amphan, stemming from the west Bengal-Bangladesh coast across the Sundarbans on 20 May 2020, with a wind speed between 155 -165 gusting up to 185 . The flooding extent is determined by analyzing the pre and post-event synthetic aperture radar images, using the change detection and thresholding (CDAT) method. The results showed an inundated landmass of 2146 on 22 May 2020, excluding Sundarban. However, the area became 1425 about a week after the event, precisely on 28 May 2020 . This persistency generated a more severe and intense flood, due to the broken embankments. Furthermore, 13 out of 19 coastal districts were affected by the flooding, while 8 were highly inundated, including Bagerhat, Pirojpur, Satkhira, Khulna, Barisal, Jhalokati, Patuakhali and Barguna. These findings were subsequently compared with an inundation map created with a validation survey immediately after the event and also with the disposed location using a machine learning-based image classification technique. Consequently, the comparison showed a close similarity between the inundation scenario and the flood reports from the secondary sources. This circumstance envisages the significant role of CDAT application in providing relevant information for an effective decision support system.
The Question of Ethical Review for Psychological Research in Indonesia: Need and Importance [Menyoal Uji Etik dalam Penelitian Psikologi di Indonesia: Seberapa Perlu dan Pentingkah?]
Authors: Himawan Karel Karsten 
Published: September 2021

Ethical evaluation is an integral part of the research process. While at the international level, ethical assessment is required for the majority of psychological studies involving direct data collection on human subjects, such assessment is largely optional in the Indonesian context. Ethical aspects, which are essential in research, are often trivialized and thus ignored. In this article, the author specifically focuses on the importance of ethical evaluation in psychological research proposals, by citing the controversial Little Albert experiment, describing the benefits of ethical evaluation for the participants, researchers, and the dignity of the profession. Lastly, the article formulates holistic recommendations for the benefit of developing psychological research in Indonesia.
Evaluasi etik merupakan bagian yang tidak terpisahkan dari proses penelitian. Walaupun di tingkat internasional mayoritas penelitian psikologi yang melibatkan pengambilan data secara langsung terhadap subjek manusia diharuskan melalui proses uji etik, di Indonesia hal tersebut masih cenderung merupakan pilihan. Aspek etik dalam sebuah penelitian, yang sebenarnya merupakan hal esensial, seringkali disepelekan dan karenanya diabaikan. Dalam tulisan ini, secara spesifik penulis berfokus pada pentingnya evaluasi etik dari sebuah rencana (proposal) penelitian psikologi, dengan menyinggung eksperimen kontroversial Little Albert, mendeskripsikan manfaat evaluasi aspek etis penelitian bagi partisipan, peneliti, dan marwah profesi. Terakhir, tulisan ini memformulasikan rekomendasi yang menyeluruh sehingga bermanfaat bagi perkembangan penelitian psikologi di Indonesia.
POTENSI KEARIFAN LOKAL HUTAN DAMAR LAMPUNG BARAT SEBAGAI KOMODITAS EKSPOR DAN OBYEK WISATA EDUKATIF
Authors: Ataji Hafis M Kaunang , Sujarwanta Agus , Triana Prita , Reneza Felzia , Bakti Hudaya Indra 
Published: September 2021

Abstrak: Perkebunan damar yang berada di Kabupaten Pesisir Barat ini adalah perkebunan rakyat yang diusahakan secara turun-temurun, bahkan ada yang mencapai usia 70 tahun dan kawasan Taman Nasional Bukit Barisan Selatan (TNBBS). Menurut Dinas Perindustrian Lampung Barat di Krui terdapat sekitar 1.750.000 pohon damar produktif dengan luas 17.500 ha. Getah damar menjadi komoditas unggulan Lampung dari Hasil Hutan Bukan Kayu (HHBK). Budidaya damar punya dua manfaat sekaligus yaitu pelestarian hutan dan ekonomi. Getah damar mata kucing banyak digunakan untuk bahan emulsi (campuran) pewarna, cat, tinta, aromatik untuk makanan, bahkan juga untuk kosmetik dan lain sebagainya. Metode yang digunakan dalam artikel ini adalah studi dokumentasi dengan menelaah atau mengkaji beberapa teori dan artikel yang berhubungan dengan Damar Mata Kucing. Pihak masyarakat sangat menantikan inovasi dari berbagai pihak yang melibatkan masyarakat dan menguntungkan daya jual damar. Inovasi yang saat ini diharapkan oleh petani adalah alat pengolah damar menjadi bahan setengah jadi sehingga harga jual akan lebih tinggi yang berdampak kepada pendapatan masyarakat. Optimalisasi obyek wisata Hutan damar perlu ditingkatkan dengan memberikan papan informasi edukatif, sejarah dan gambar penunjang lainnya.

Abstract: This damar plantation in Pesisir Barat Regency is a community plantation that has been cultivated from generation to generation, some even reached the age of 70 and the Bukit Barisan Selatan National Park (TNBBS) area. According to the West Lampung Industry Service in Krui there are about 1,750,000 productive resin trees covering an area of ​​17,500 ha. Dammar sap is Lampung's leading commodity from Non-Timber Forest Products (HHBK). The cultivation of resin has two benefits, namely forest conservation and the economy. Cat's eye resin is widely used for emulsion (mixture) of dyes, paints, inks, aromatics for food, even for cosmetics and so on. The method used in this article is a documentary study by examining or examining several theories and articles related to cat's eye resin. The community is looking forward to innovations from various parties that involve the community and benefit the selling power of resin. The innovation that is currently expected by farmers is a means of processing resin into semi-finished materials so that the selling price will be higher which will have an impact on people's income. Optimization of the Damar Forest tourism object needs to be improved by providing educational information boards, history and other supporting images.
Possibility of Application of the User Interface of a Conventional Smartphone for Communication of Graphical Information with a Special HW/SW Device
Authors: Hortobágyi Aaron , Pivarčiová Elena 
Published: September 2021

Abstract
This article is focused on enhancement of HW/SW device by cooperation with a smartphone interface. The device was a programmable Lego Mindstorms Education EV3 set in the form of a robot designed to solve the Rubik’s Cube. The aim of the research was to replace the built-in color sensor with a camera that would allow the cube scanning process to be accelerated. Two approaches were chosen to meet the goal: the NXTcam camera, accessible as an accessory to expand the set, and the camera built into the smartphone. The use of NXTcam led to better scan time, but this result was prone to external influences. The camera on the smartphone sped up the scanning process to 57% of the original time. The impact of external factors on the outcome was significantly lower, compared to NXTcam. In the experiment, the cube solving process was observed in natural light, with addition distractive light source and in artificial light.
The Prospects of Abrasive Treatment of Tough-To-Machine Materials
Authors: Palacz Magdalena , Ivanova Tatiana N. , Kozlov Alexander M. , Kaniak Wojciech 
Published: September 2021

Abstract
In current conditions, great attention is paid to the quality of parts, which is in many ways determined by finishing operations of mechanical treatment, with surface grinding being the most widespread. Grinding process efficiency, abrasive tool wear intensity, machined surface quality and other features of grinding process depend on properties of the environment, where the cutting process takes place. Forced changing of conditions of this environment is one of the ways to control and optimize the grinding process, which can be reached due to finding new technological decisions. One of the most promising directions to solve this problem is the process of face grinding with discontinuous grinding tool and supply of cooling fluid or air in the cutting zone directly. Carried analysis of features of face grinding has shown that heat density can be decreased by the usage by grooved wheels with vortex air cooling or by supply of cooling-lubricant technological fluid. Obtained dependences of temperature field of part surface during grinding establish the influence of the length of working shoulders and grooves, vortex tubes number, outflow rate, temperature and flow rate of cold vortex flow of air. These data provide conscious control over the process of discontinuous face grinding by changing wheel grain size and grinding speed.
The Impact of Remote Working During the COVID-19 Epidemic on Employee Well-being
Authors: Nowacki Krzysztof , Grabowska Sandra , Lis Teresa 
Published: September 2021

Abstract
The aim of the research was to answer the question whether the remote work imposed on workers during the COVID-19 epidemic has an impact on their well-being, and if so, how. The research material consisted of the results of a survey conducted among the employees referred to remote work in connection with the announced state of the epidemic in Poland. The research was conducted in the period from July 31 to August 19, 2020. The research was conducted using a questionnaire method, the study was attended by 199 respondents. A survey questionnaire was used in the study and the results obtained were statistically processed. The research carried out allowed us to obtain the results of the self-assessment of employees referred to work in the homme-office in terms of their mental well-being and physical well-being.
Determination of Coal Cutting Forces Using the Cutting Head of POU-BW/01-WAP Device
Authors: Biały Witold , Fries Jiri , Galecki Greg 
Published: September 2021

Abstract
The paper presents a method for measuring and recording the forces involved in the coal cutting process. Moreover, a method for visualization of all forces involved in the cutting process was described. In the following part, the construction and principle of operation of a device for determination of forces involved in the cutting process (coal mining), referred to by the author as POU-BW/01-WAP, are presented. Resistance extensometry was used to measure the forces. This is the only device in the world that determines two of three force components that take part in the cutting process. For this purpose, two independent measuring blocks were used, which are strain gauges of force: cutting (Fs) and knife pressure (Fd). In order to register these forces, a real mining knife used in longwall shearer drums was applied – i.e. tangential-rotary. The equipment has the ATEX certificate allowing for operation in real conditions as a device intended for use in potentially explosive atmospheres – in accordance with the directive 94/9/EC. It has received many awards at world fairs for inventions and innovative solutions.
Technology Analysis and the Need of a Value Framework
Authors: Lekka-Kowalik Agnieszka 
Published: September 2021

Abstract
The idea that technology is only a value-neutral instrument that can be used for good and bad purposes is not tenable anymore. Technology shapes our human life in all its dimensions and determines the direction of social changes. In the paper, I first show a few arguments in favor of the value-ladenness of technology and then approaches developed in response to that fact. I will argue that none of those responses is satisfactory, for they lack a formative value framework that would serve for decisions and their justification in the realm of technology development. Building such a framework requires a transdisciplinary and cooperative effort.
Limitation of Manufacturing Defects of the Selected Product in the Glass Mill
Authors: Konopek Sonia , Zarębska Joanna , Żabińska Iwona 
Published: September 2021

Abstract
In the era of global market and internationalization of enterprises, an extremely important element influencing the competitiveness of companies is ensuring high quality of manufactured products, taking into account the requirements and expectations of buyers. At the moment when defects appear in the manufactured product, the production plant ceases to meet the expectations of customers. Not only is this related to the costs of production or complaints, but above all to the loss of credibility and good customer opinion. It is extremely important to identify and analyze the causes of this phenomenon as soon as possible, without allowing it to repeat itself. The problem of manufacturing defects becomes even more important when it poses a threat to the health or life of the customer. This also applies to products manufactured for the purposes of food protection. This article presents the results of the research that enabled the development of a method to reduce the production defects of a selected product in a glass factory. In order to achieve the goal, an analysis of the production process of the selected glass packaging was carried out, which allowed to identify defects and determine the causes and effects of their formation. Based on the presented research results, improvement measures have been proposed, consisting in developing a new organization of work in the area of quality control.