bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of 6 Weeks of Aerobic Training with Nanocurcumin Consumption on IL1β, Nitric Oxide, and Depression in Women with Metabolic Syndrome
Authors: Osali Ali , Rostami Alireza 
Published: April 2021

Abstract
Backgrounds and ObjectivesThe use of anti-inflammatory supplements is important in improving the executive function of obese people. The aim of this research was to investigate the effect of 6 weeks of aerobic exercise with moderate intensity and consumption of nanocurcumin on IL1β, nitric oxide, and depression in women aged 60-65 with metabolic syndrome. Materials and Methods44 women with metabolic syndrome (MetS) were randomly selected and divided into four groups of 10, including MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS NanoCurcumin (MCU), MetS control (MC Training groups performed an exercise protocol of aerobic exercise for 6 weeks (three sessions per week). Blood samples were obtained before and after the training period for antioxidant indicators and lipid degradation measurement. Also, the Beck anxiety questionnaire was used for evaluating levels of anxiety. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively.ResultsThere was a significant difference in IL1β, nitric oxide (NO), and depression before and after exercise in all three experimental groups (p≤0.05). Also, the results showed a significant difference in the level of NO and depression in the research groups. The highest decrease in these variables was observed in the aerobic training group and training with nanocurcumin consumption group (p≤0.05).ConclusionThese findings indicated that six-week nanocurcumin supplementation with aerobic training is a suitable method for reducing IL1β and NO and depression, preventing metabolic, cardiovascular, and inflammatory diseases in women with metabolic syndrome.Name of the registry: IR.SEMUMS.REC.1396.107Trial registration number: IRCT2017082335857N1
Anthropometry study using adult Pelvic 3D Ct For Determining Sexes at Dr. Soetomo General Hospital, Indonesia
Authors: Setiawati Rosy , Ruriana Ika , Priyambodo Priyambodo , Guglielmi Giuseppe 
Published: April 2021

Abstract
Background

Pelvic bones are the most reliable indicator of sex in adults because of its sexual dimorphism. Medical imaging modalities e.g. Computed Tomography (CT) provide data sources to examine modern human variation quantitatively. This study aims to determine pelvic anthropometry characteristics and logistic regression formula for adult sex identification obtained from pelvic 3D CT.
Methods

This study was an observational analytical study with retrospective regression and cross-sectional approach. The population was all patients in Radiology Installation of Dr. Soetomo General Hospital, Surabaya, Indonesia, from September to December 2019 who underwent pelvic 3D CT examination. Then, age distribution and pelvic measurements data were obtained. In this case, statistical analysis was conducted for all the data obtained.
Results

A number of 204 samples were included in this study. Mean age of the patients was 50.23 ± 14.36 years. All radiologic components were also significantly different between sexes (p < 0.05) except for transverse diameter of sacral segment (p = 0.180). Moreover, eta test was performed and found that APOD, CPID, LIH, TPO, and SPA had the strongest correlation. Those variables were used for making statistical models with logistic regression as sex = (0,125 x CPID) – (0,180 x LIH) + (0,078 x SPA) + 8,912. The calculation result > 0 is a prediction for female while < 0 is a prediction for male. From logistic regression model calculation, a high validity value (91.05%) was found with 100% sensitivity to identify male sex and 81.1% specificity to identify female sex.
Conclusion

There were differences on radiometric variable characteristics in pelvic anthropometric study. The regression formula for sex determination in adults using 3D-CT pelvic provides a pelvic model sex determination with higher validity and sensitivity for male identification, as well as higher a specificity for female identification
Synthesis and Application of [Zr-UiO-66-PDC-SO3H]Cl MOFs at The Preparation of Dicyanomethylene Pyridines via Chemical and Electrochemical Methods
Authors: Naseri Amir Mohammad , Zarei Mahmoud , Alizadeh Saber , Babaee Saeed , Zolfigol Mohammad Ali , Nematollahi Davood , Arjomandi Jalal , Shi Hu 
Published: April 2021

Abstract
A metal-organic frameworks (MOFs) with sulfonic acid tags as a novel mesoporous catalyst was synthesized. The precursor of Zr-UiO-66-PDC was synthesized both via chemical and electrochemical methods. Then, zirconium based mesoporous metal-organic framework [Zr-UiO-66-PDC-SO3H]Cl was prepared by reaction of Zr-UiO-66-PDC and SO3HCl. The structure of [Zr-UiO-66-PDC-SO3H]Cl was confirmed by FE-SEM and TEM. This mesoporous [Zr-UiO-66-PDC-SO3H]Cl was successfully applied for synthesis of dicyanomethylene pyridine derivatives via condensation of various aldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and malononitrile. At the electrochemical section, a green electrochemical method has successfully employed for rapid synthesis of the zirconium based mesoporous metal-organic framework UiO-66-PDC at room temperature and atmospheric pressure. The synthesized UiO-66-PDC has a uniform cauliflower-like structure with 13.5 nm mean pore diameter and 181.6 m2­ g-1 surface area. The described catalyst [Zr-UiO-66-PDC-SO3H]Cl was also employed for the convergent paired electrochemical synthesis of dihydropyridine derivatives as an environmental friendly technique under constant current at 1.0 mA cm-2 in an undivided cell. The proposed method proceeds with moderate to good yields for the model via a cooperative vinylogous anomeric based oxidation.
Dynamic Changes of Scleral Spur Length In Different Accommodation States
Authors: Chen Liugui , Jin Wei , Hao Xinlei , Li Xuejie , Xing Yiqiao 
Published: April 2021

Abstract
This study aimed to evaluate the scleral spur length in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal and trabecular meshwork. 74 children were recruited for this study. The 0D, -4D, and − 8.0 D accommodation state was stimulated by looking at a variable distance optotype. The ciliary muscle, scleral spur, Schlemm’s canal, and trabecular meshwork were imaged by swept-source optical coherence tomography. The scleral spur length increased with accommodation stimulation (p < 0.05). Method I was 127.97 ± 20.32 µm, 138.29 ± 20.11 µm, and 150.73 ± 21.75 µm at 0D, -4D and − 8D, respectively. Method II was 158.15 ± 19.97 µm, 168.47 ± 18.72 µm, and 179.79 ± 20.83 µm at 0D, -4D and − 8D, respectively. Method III was 221.56 ± 30.74 µm, 234.99 ± 30.11 µm, and 250.09 ± 29.87 µm at 0D, -4D and − 8D, respectively. Method III had the largest areas under ROC curves (0.798, 95% CI 0.721–0.875). Moreover, ciliary muscle 1, Schlemm’s canal, and trabecular meshwork length were significantly correlated with SSL (Method III) (p < 0.05). These findings suggest that the contractile ability and compliance of the scleral spur play an important role in maintaining the morphology of the SC. Moreover, the force of accommodation regulates the SC size by increasing the length of SS.
COVID-19 Anosmia and Lacunar Stroke.
Authors: Foyaca-Sibat Humberto , Ibañez-Valdés Lourdes de Fátima 
Published: April 2021

Abstract
Background: Despite the worldwide COVID-19 vaccination programme, there is not enough information to predict when the current pandemic will end, and new variants of SASR-CoV-2 are travelling worldwide, leading to the new variability of clinical manifestation, complications and increasing fatal outcomes. Many publications on COVID-anosmia and asymptomatic COVID-stroke have been released, and plenty of studies on novel therapeutic approach have been published. Here we report an atypical case, our findings from review the medical literature, and comment on the treatment modalities. Material and Method: EMBASE, Medline, Scopus online databases, Google Scholar, Science Direct, WHO database, Scielo, LILACS, BIREME, and Cochrane library to identify articles evaluating anosmia*, COVID-19 anosmia*, aetiology of anosmia*, lacunar infarct*, treatment of IS*, and COVID-19 acute stroke* from January 1, 2010, to March 30, 2021.Results: We found 2454publications related to these topics. After removing duplicate articles, considering the title and abstracts, screening full text, PCR positives, symptomatic patients, and manuscript written in other languages, only six matches all the selected parameters, but from this group, none one presented COVID anosmia/PCR negative/ No respiratory disturbances/presence of IgG/ lacune larger than 15 mm (macunes).Case presentation: A 17-years-old male came to the medical outpatient clinic complaining of loss of smell without other symptomatology. The PCR test for SARS-Cov-2 done was negative, and then he did not receive COVID-19 treatment. Four weeks later patient back to the hospital because of no improvement and was admitted to the hospital neurology ward. Apart from anosmia, examination of other systems shows unremarkable findings. We did an extensive serological and CSF work-up to exclude almost all causes of anosmia. Brain MRI confirmed focal oval cyst space with CSF signal measuring 17 mm in the external capsule in the left basal ganglia region like a lacune (macune) from a previous vascular insult.Comments and final remarks: After an extensive literature review of published manuscript related to these topics, we did not find a report like our case, which presented COVID-19 anosmia/ without respiratory symptomatology/silent macune stroke/PCR negative with positive antibodies, apart from the systematic review of published articles related to these issues. We also included an updated list of anosmia aetiology and the recommended treatments for LS published in the medical literature.
Pulmonary Lymphangitic Carcinomatosis as the Initial and Only Presentation of Gastric Cancer in a Young Male and Literature Review
Authors: Li Dandan , Yuan Zhenhua , Wang Haibo , Zhang Xudong , Zhang Xiaoju 
Published: April 2021

Abstract
BackgroundPulmonary lymphangitic carcinomatosis (PLC) is a malignant lung disease characterized by metastatic tumor lesions in the lung lymphatic vessels with a poor prognosis. Early diagnosis is the key to improve the outcome. However, when PLC is the first manifestation of patients without a known malignancy, it often leads to delayed diagnosis and treatment, and even fatal consequences due to non-specific symptoms. Here, we describe a young male presenting PLC as the first and only manifestation followed by diagnosis of gastric adenocarcinoma and systemically summarized previously reported clinical properties of PLC cases in the literature.Case presentationA 32 years old male presented nonproductive cough for 20 days and progressive exertional dyspnea in a week. He was diagnosed with pneumonia and received antibiotics for almost 3 weeks without any improvement. Chest computed tomography showed multiple nodules and thickened interlobular septa in bilateral lung. PET/CT revealed a primary gastric tumor with PLC and the biopsy of the cervical lymph node confirmed a poorly metastatic differentiated gastric adenocarcinoma. The patient’s general condition deteriorated rapidly and he developed respiratory failure, requiring non-invasive mechanical ventilation on day 9 after admission. Chemotherapy was given to the patient on the tenth day. However, few hours after receiving the first dose, the patient died of respiratory failure. It was only one month from the onset of symptoms to death of our case.ConclusionsPatients presenting PLC as the first manifestation of an unknown malignancy carry a bleak prognosis. PLC be considered for differential diagnosis in patients who present with dyspnea, dry cough with or without loss of weight. Particular attentions need to be given to patients, especially young ones without histories of malignancy, whose chest imaging exhibits thickened interlobular septa. While the stomach, lung and prostate are the most likely origins of the primary tumors, patients with PLC derived from prostate cancer may have a better prognosis after anti-cancer treatment.
Minimal Variation of Human Oral Virome and Microbiome in IgA Deficiency Challenges an Irreplaceable IgA Role for Shaping Oral Commensal Microbiota
Authors: José de la Cruz Peña Maria , Gonzalez-Granado Luis Ignacio , Garcia-Heredia Inmaculada , Carballa Lucia Maestre , Martinez-Garcia Manuel 
Published: April 2021

Abstract
Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by `recognizing´and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (2-fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results challenge the view of an irreplaceable IgA role for regulating the composition and function of our commensal microbiota and pose the question whether other “back-up” Ig-independent mechanisms might exist for maintaining a functional commensal microbiome.
Study of Limnological Status of Two Selected Floodplain Wetlands of West Bengal
Authors: Ziauddin Golam 
Published: April 2021

Abstract
Limnology is the study of all aquatic systems, both lentic and lotic fresh, fresh, and saline including lakes, wetlands, marshes, bogs, ponds, reservoirs, streams, rivers, oceans, etc. about their physical, chemical, and biological characteristics. Among this phytoplankton, Zooplankton, periphyton, benthos are a minute aquatic free-floating microscopic organism, which acts as a larger food source of larval and higher vertebrates and invertebrates including carnivorous and omnivorous fishes. They are related to the growth of juvenile fishes and are also play important role in the transfer of energy from the primary phytoplankton to higher trophic levels. The plankton community fluctuates according to the physicochemical parameters and the relative environment of the water body especially the Rotifers as they are known to change immediately along with the change in water quality . Realizing the importance of floodplain wetlands and the paucity of literature on the limnology of this ecosystem present investigation was carried out in two floodplain wetlands having characteristics of open (Kole beel, an ox-bow lake formed near Somra Bazar in Hooghly district), and closed beel Suguna beel situated in Nadia District of West Bengal) system during the period 2011–2013. The physicochemical parameters of the investigated beels' water and soil were, for the most part, favorable for planktonic development. It has an alkaline pH of 7.5–8.4 and is alkaline. The dissolved oxygen content and Secchi Disc transparency values indicate that the water is in excellent condition. The water was moderately hard, with only trace amounts of nutrients present. Seasonal fluctuations in the water column were apparent, and they were mainly attributable to replenished supplies and volume. The plankton population of the studied ecosystem was made up of a mixed and healthy population of diverse fauna. The greatest diversity was observed during the winter season, when favorable temperature, dissolved oxygen, and other physicochemical parameters of water, as well as optimal solar penetration, coincided. In a closed system (Suguna), the richness of planktonic structure resulted in higher fish production (1570.05 kg/ha/yr) than in an open system (Kole) (384.4 kg/ha/yr). The status of floodplain wetlands was determined to be eutrophic based on various Physico-chemical and biological parameters.
Low Dietary Diversity Score is the Cause of Underweight Among Expectant Mother from Rural Ethiopia: A Community Based Cross-Sectional Study
Authors: Assefa Nigussie , Efram Kibret , Haidar jemal 
Published: April 2021

Abstract
Background: Maternal underweight is a challenging public health issues globally affecting women in most developing countries and consequently affect their newborns. Such information however is scantly in the study area and thus we examined the contribution of low dietary diversity score towards underweight among expectant mothers from rural Ethiopia.Methods: This study was based on data extracted from a large data set gathered from three rural villages from September 2017 to June 2018 in a district of North-Shewa Zone of Amhara Regional State which is 220 km north of Addis Ababa, the capital city of Ethiopia. Data on socio demographic characteristics food groups consumed and Mid-Upper Arm Circumference (MUAC) measurement were taken for all expectant mothers by trained health extension workers in accordance with relevant ethical guidelines and regulations. The collected data were entered into Epi-data software version 3.02 and analyzed using SPSS version 20. Statistical significance was affirmed at a p-value ≤ 0.05. Result: Of the 400 consented participants, 380 of them had adequate information and thus analyzed for their variety of food groups consumption and their MUAC measurement outcomes. The magnitude of underweight was 18.2% and the mean (±SD) dietary diversity score was 4.45(±1.32). interestingly, the relationship between poor dietary diversity score and underweight of the participants was significant (AOR= 2.4; 95% CI=1.05 to 5.3). Conclusion: Our study revealed a significant relationship between low dietary diversity score and underweight of expectant mothers. it is thus, essential to improve the dietary diversity and nutritional status of pregnant women through strengthening the ongoing productive safety net program and empower women to earn more income so that mothers would purchase variety of foods and ultimately break the intergeneration cycle of malnutrition.
Differential long non-coding RNA expression profile and function analysis in primary Sjogren’s syndrome
Authors: Chen Xiaochan , Cheng Qi , Du Yan , Liu Lei , Wu Huaxiang 
Published: April 2021

Abstract
Background: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by abnormal immune cell activation. This study aimed to investigate differentially expressed long non-coding RNA (lncRNA) in peripheral blood mononuclear cells (PBMCs) in patients with pSS to identify lncRNAs that affect pSS pathogenesis. Methods: Total RNA was extrated from PBMCs of 30 patients with pSS and 15 healthy persons. Transcriptome sequencing was used to screen differentially expressed lncRNAs and mRNAs in 8 RNA samples from the discovery cohort. The differentially expressed mRNAs underwent functional enrichment analysis. A protein interaction relationship (PPI) and ceRNA network was constructed. Real-time PCR was used to validate screened lncRNAs in all 45 RNA samples. Results: 1180 lncRNAs and 640 mRNAs were differentially expressed in pSS patients (fold change > 2 in healthy persons). The PPI network was constructed with 640 mRNAs and a ceRNA network with four key lncRNAs (GABPB1-AS1, PSMA3-AS1, LINC00847 and SNHG1). RT-PCR revealed that GABPB1-AS1 and PSMA3-AS1 were significantly upregulated 3.0-and 1.4-fold in the pSS group, respectively. The GABPB1-AS1 expression level was positively correlated with the percentage of B cells and IgG levels. Conclusions: GABPB1-AS1 was significently upregulated in pSS patients, and its expression level is positively correlated with the percentage of B cells and IgG levels. GABPB1-AS1 may be involved in the pathogenesis of pSS.
A pre-post evaluation of oncology healthcare providers’ knowledge, attitudes, and practices following the implementation of a complementary medicine practice guideline
Authors: Hayward Emilie N , Watling Cody Z. , Balneaves Lynda G. 
Published: April 2021

Abstract
PURPOSE

Complementary medicine (CM) use is prevalent among cancer patients, yet it is often not assessed by oncology healthcare providers (HCPs). The purpose of this study was to evaluate oncology HCPs’ knowledge, attitudes, and practices surrounding CM use before and after the implementation of a practice guideline focusing on standardizing assessment and documentation of CM.
METHODS

Oncology HCPs across a provincial cancer agency were invited to participate in the study. The implementation strategy included an initial education session for HCPs and standardized CM assessment forms. Pre-post surveys assessing knowledge, attitudes, and practices related to CM were completed by HCPs prior to attending the education session and following the 4-month implementation period. Paired t-tests were conducted to determine differences between baseline and follow-up surveys.
RESULTS

A total of 31 oncology HCPs completed both baseline and follow-up surveys, with over 3,700 patient CM assessment forms being completed during the 4-month study period. At the end of the study, HCPs reported greater CM knowledge (p < 0.001), readiness to support cancer patients’ CM decisions (p = 0.002), and willingness to consult with another HCP about CM (p = 0.004). No significant change in HCPs’ reported attitudes towards CM, or clinical practices related to CM were observed.
CONCLUSION

Implementing a practice guideline, including a CM education session and a standardized assessment form was found to improve oncology HCPs’ self-reported CM knowledge and readiness to answer cancer patients’ questions about CM. The findings provide support for future knowledge translation research aimed at standardizing how CM is addressed within cancer care settings.