bluuebunny/crossref_metadata_2025_split huggingface dataset:
POTENSI ANTIBAKTERI EKSTRAK ALGA HIJAU Halimeda makroloba Decaisne DARI PERAIRAN DESA HUTUMURI KOTA AMBON
Authors: Sampulawa Sriyati , Nirmala Wa 
Published: October 2021

Perkembangan penggunaan obat-obatan tradisional untuk membantu meningkatkan kesehatan masyarakat sudah cukup meluas, salah satu tumbuhan yang sering digunakan dalam bidang kesehatan yaitu alga hijau, penggunaan alga hijau karena memiliki senyawa metabolit sekunder yang efektif dalam menghambat pertumbuhan bakteri, namun isolasi senyawa aktif dari alga hijau yang efektif dalam menghambat pertumbuhan bakteri masih jarang dilakukan, salah satunya Halimeda makroloba Decaisne sehingga perlu dilakukuan isolasi dan identifikasi senyawa yang aktif dalam menghambat pertumbuhan bakteri. Untuk mengetahui potensi antibakteri ekstrak alga hijau Halimeda makroloba Decaisne dari perairan Desa Hutumuri Kota Ambon dapat dilakukan melalui beberapa tahapan yaitu proses pengambilan sampel, proses ekstraksi, proses uji fitokimia uji daya hambat bakteri. Berdasarkan hasil penelitian uji fitokimia menunjukan bahwa ekstrak alga hijau Halimeda makroloba Decaisne kandungan senyawa Alkoloid, Flavonoid, Terpenoid, Fenolik, dan saponin yang berperan dalam menghambat pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Kemampuan ekstrak alga hijau Halimeda makroloba Decaisne dalam menghambat pertumbuhan bakteri Escherichia coli pada konsentrasi 10%, 20%, 40%, 60% dan 80%, dan Kemampuan ekstrak dalam menghambat bakteri Staphylococcus aureus pada konsentrasi 60% dan 80%.
Effectiveness Comparison Between Young Leaf Extracts Acacia nilotica with Desmanthus virgatus Against Vermicidal Potency of Haemonchus contortus In-vitro
Authors: Wirawan I Gusti Komang Oka , Aoetpah Aholiab , Jacob Jois Moriani 
Published: October 2021

Acacia nillotica and Desmanthus virgatus are two entopharmacologycal plants that thrives throughout the season in East Nusa Tenggara Province, other Provinces in Indonesia or tropical countries. Extraction of young leaves of Acacia nillotica (EDMAN) and Desmanthus virgatus (EDMDV) contains tannin compound. By pharmacodynamic viewpoint, this extraction has potency as an anthelmintic. Objective: to compare the in-vitro effectivity of young leaves extraction of the two plants as a vermicidal power to combat Haemonchus contortus. Materials: young leaves of Acacia nillotica and Desmanthus virgatus and Haemonchus contortus. Method: The study was grouped into four treatments: EDMAN, EDMDV, Positive control (Albendazole 0,055%) and negative control (aquades). The concentration of the young leaves extracts are 2.5%, 3.5%, 4.5% out of 0.01 g/mL of extraction. Each treatment was applied to 6 female Haemonchus contortus with four replicates allowing immersion time for 1, 3, 5 or 7 hours. Variable measured and tested was mortality of the H. contortus. The vermicidal effectively was descriptively analysed. The results showed that mortality percentage (vermicidal) treatment of 2.5%, 3.5%, 4.5% EDMAN for 7-hour immersion was 16.7%, 45.8%, 12.5%, respectively. That values for EDMDV for similar concentrations and immersion time was 50%, 33.3%, 12.5%, respectively. Conclusion: EDMDV has a more effective vermicidal power between the two etnopharmacological treatments at 2.5% concentration.
Consideraciones para fortalecer la vinculación universitaria en territorios rurales. Reflexiones con base en el estudio de sistemas de producción
Authors: Tamayo Christian Vicente , Cuichán Catagña Doris Pilar , Ayala Rodríguez Vinicio Germán , Pumisacho Gualoto Manuel María , Sevillano Vásquez Gustavo Fernando 
Published: October 2021

En la parroquia Puéllaro se identificó la dinámica agraria y el modelo actual de vinculación con la sociedad con el objetivo de generar algunas consideraciones que se puedan aplicar para fortalecer el proceso impulsado en este territorio. Para el efecto, se realizaron recorridos de campo, entrevistas y estudios de caso en fincas, considerando tipologías de productores. Las actividades son realizadas mediante la articulación de dos actores: universidad y gobierno local en el marco de un proyecto de servicio comunitario. El principal sector intervenido se sitúa en áreas bajas y cálidas con producción frutícola; sin embargo, el análisis agrario evidenció la existencia de otras zonas agroecológicas con características productivas distintas, problemáticas más complejas y condiciones de vulnerabilidad de la población. Las pautas para fortalecer el trabajo promovido están relacionadas con: (i) Considerar la diversidad agroecológica y tipología de productores; (ii) Estructurar equipos interdisciplinarios; (iii) Promover mayor participación de líderes comunitarios y productores; y (iv) Explorar otras líneas de acción, especialmente a través de la investigación y educación continua. La realidad campesina identificada, en relación al limitado acceso a la tierra, carencia de riego y bajos ingresos agrícolas, puso en evidencia la necesidad de articulación con otros actores con competencia en el sector rural. Los elementos generados constituyen una guía para fortalecer el servicio a la colectividad en el sector rural y orientar la formulación de propuestas más amplias.
Complex Tibial Plateau Fractures Treated with a Hybrid External Fixator – Long Term Results
Authors: Andonov Y. 
Published: October 2021

Abstract

Introduction: High energy tibial plateau fractures represent a challenge because of the combined bone and soft tissue injury. The iatrogenic impact can further increase the likelihood for crippling complications. Less invasive treatment protocols have been developed to improve the results.

Objective: We present the long-term results of limited internal fixation combined with a small wire external fixator.

Patients and Methods: Fourteen patients were followed for at least 10 years. Initial and final functional results, complications and presence of joint degeneration were registered according to validated rating scores.

Results: Of all patients included in the study, thirteen showed an excellent initial rating and one had an average result at baseline. 10 years later, eight patients still showed excellent grading results, four – good ones, one – average and one – poor results. Ten knees (71%) had osteoarthritis. Postphlebitic syndrome was diagnosed in two cases. Three knees showed medio-lateral instability, one showed a varus and one – a valgus deformity. Knee arthroplasty was performed in one case.

Conclusion: The limited internal fixation combined with a hybrid ex fix can be considered as an alternative to the ORIF, especially when the soft tissues are severely compromised. Despite the inevitable joint degeneration, the associated overall morbidity is low and the long term function is quite satisfactory.
DISHphagia – A Riddle Unwrapped a Clinical Case with Literature Review
Authors: Valkov H. , Kovacheva-Slavova M. , Lyutakov I. , Angelov T. , Getsov P. , Vladimirov B. , Penchev P. 
Published: October 2021

Abstract
Diffuse idiopathic skeletal hyperostosis (DISH) is a common but underdiagnosed systemic skeletal disease. It is characterized by calcifications affecting mainly the spinal anterior longitudinal ligament. In the majority of cases, the patients are asymptomatic, but cervical osteophytes can sometimes cause hoarseness, dysphagia (DISHphagia) and even dyspnea.

Case description: A 61-year-old man was admitted to our department with complaints of difficulty in swallowing and weight loss. Dysphagia had been increasing gradually for nine months. Barium swallow esophagram revealed asymmetric swallowing with expansion above the upper esophageal sphincter without other abnormalities. The extension was confirmed by esophago-gastro-duodenoscopy (EGD). Furthermore, CT scan of the thorax clearly demonstrated degenerative changes of the cervical and thoracic region, extensive ossification of the anterior longitudinal ligament, and osteophytes from C2-C7 with a forward displacement of the esophagus by 14 mm. The so-called “wax dripping down the candle” phenomenon was as well observed.

Conclusion: DISH is a systematic, musculo-skeletal disease of older adults with unknown etiology. Dysphagia is the most common symptom of the disease and might be caused by osteophytes of the cervical region. We presented a case of DISH with a rare localization of the osteophytes in the cervical region C2-C7. Due to the increasing incidence of the Forestier’s syndrome and its associated “DISHphagia”, the gastroenterologist should increase the awareness of this underestimated disease and improve the diagnostic approach.
Er:Yag Laser Root Modification for Single Root Recession Class III Coverage – Case Report
Authors: Yaneva B. 
Published: October 2021

Abstract
Gingival recession is a common dental condition causing esthetic and functional problems to the patients. In the present case report gingival recession Miller class III is treated with bilaminar technique and subepithelial connective tissue graft where the tooth root surface is modified by Er:YAG laser and the case is observed for 5 months. There were no complications or side effects during the surgery and the healing period. The patient was stable after 5 months of follow-up. It could be concluded that the Er:YAG laser could be used in addition to mucogingival surgery, but longer observation and more studies are needed to clarify and prove its adjunctive application.
Neurological Manifestations of Hospitalized Patients with Covid-19: A Case Series Study
Authors: Zamanian M. H. , Janbakhsh A. , Mansouri F. , Sayad B. , Afsharian M. , Vaziri S. , Mahdavian B. , Afshar Z. M. , Miladi R. , Shirvani M. , Noori M. , Salimi M. , Babazadeh A. , Ebrahimpour S. 
Published: October 2021

Abstract
There are some reports about the neurological manifestations and complications of COVID-19. We present neurological manifestations in 6 hospitalized patients with COVID-19. The patients presented with common symptoms of COVID-19 along with common findings from high-resolution computed tomography (HRCT) scan such as ground-glass opacities (GGOs). Though, RT-PCR testing of SARS-CoV-2 was negative for all 6 cases. In the current report, acute cerebrovascular diseases affected older patients, while dementia, seizure and encephalopathy affected younger ones. Three of the 6 patients had proven strokes based on their neuroimaging. Four of the 6 patients had high d-dimer levels. Two of the cases experienced convulsion. The third patient presented with typical symptoms and signs of neuroleptic malignant syndrome. The sixth case was interesting for transient dementia. Unfortunately, four out of six patients died. The recent case series report the association between neurological involvements and COVID-19 infection. Clinicians should be alert of the neurologic symptoms in the setting of COVID-19, which might even be the first presentations of this infection.
Results from Observational Studies in Real Therapeutic Practice in Patients with Covid-19
Authors: Milushewa P. K. 
Published: October 2021

Abstract
The aim of the present work is to summarize the available data from observational studies performed in a real clinical setting of patients with active COVID-19 infection.A systematic review of publications in the scientific medical literature was conducted during the period from the beginning of the infection to the end of June, 2021. All of the 28 publications included in this review are full-text, observational studies published in English, conducted in a real clinical environment and present data on patients, who have been infected with COVID-19. Out of the 28 studies, 4 reviewed the possibility of a mother to infect her newborn during pregnancy or breastfeeding and found no risk to children. One study was related to children and adolescents of all races and included also patients with MIS-C and comorbidities. Non-invasive mechanical ventilation (HFNC) with a nasal cannula in patients with respiratory failure has been also explored and was reported to lead to a positive outcome. Three papers were dedicated to assessment of COVID-19 Standard of Care (SoC), in particular administration of hydroxychloroquine and doxycycline, favipiravir and remdesivir. Another three articles reviewed a large cohort of hospitalized patients with COVID-19. The mortality was higher in patients who were in the ICU. Observational studies of patients with COVID-19 in a real life setting are relatively limited, but provide valuable information on the risks of the disease in adults, children and newborns, as well as the treatment of complications of the infection.
Atopic Dermatitis: From Etiology and History to Treatment
Authors: Dourmishev L. , Mironova N. 
Published: October 2021

Abstract
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease in patients with atopy. Atopy itself, is defined as a predisposition to develop immune response with overproduction of immunoglobulin E to low doses of allergens. AD is one of the most common skin disorders in the developed world, affecting up to 20% of children and about 3% of adults. The pathogenesis of the disease is complex, with both genetic and environmental factors playing a significant role in it. Clinically, hallmarks of atopic dermatitis include dry, itchy skin and various cutaneous efflorescence, compatible to dermatitis or eczema. Atopic dermatitis subdivides into three morphological variants manifesting during infancy, childhood and adulthood. Various environmental factors and associated diseases may have serious influence on the clinical course or may trigger disease relapses. The aim of this review article is to serve as a comprehensive overview of the etiology, pathogenesis, clinical course and diagnosis, as well as potential challenges facing the successful treatment of atopic dermatitis.
Infection, Inflammation and Immunity in Covid-19 Infection
Authors: Cherneva R. , Cherneva Z. 
Published: October 2021

Abstract
The COVID-19 pandemic caused by the SARS-CoV-2 has increased the burden on healthcare system. Despite some progress in its diagnostics has been made, effective prevention and treatment are still insufficient. Since SARS-CoV-2 infections often cause systemic inflammation and multiple organ failure, the therapeutic options aimed at modulating the host immune responses to prevent subsequent systemic complications are demanding. The review provides a summary of the SARS-CoV-2 virus infection and underlines the current perception of pulmonary host’s immune response and its contributions to disease severity and systemic inflammation. Signaling pathways which have the potential to manipulate host immunity and improve clinical outcomes are also presented.
Do Praguers differ from Czechs? Selected topics of recent intergroup antagonism attempts
Authors: Jarabinský Ivan 
Published: October 2021

Abstract
Due to the recent attempts to divide Czech society based on the antagonism between Prague and the countryside, this study researches some of the aspects of this division—basic human values and the national identity of the inhabitants of Prague. These very basic level sources of the antagonism are researched via a combination of ISSP (National identity III module) and ESS (Round 8) surveys and two focus groups with Prague inhabitants. The results show that there are no real, or wrongly interpreted, differences between Praguers and people in the countryside with respect to both basic human values and Czech national identity. Regarding the basic human values of the two groups, only the conservation value dimension is stronger outside Prague. However, this value dimension is inherently ambiguous because its value of security is stronger within Prague, which is in contrast to values of conformity and tradition that are stronger outside Prague. In addition to this, conservation is still the stronger dimension within Prague compared with the openness to change value dimension. Praguers are rather compelled to be open and they are capable of adapting, even if their values are more conservative. The same values prevail among people within and outside Prague, which has been confirmed in the focus groups. There are also more similarities between the two groups in their national identities, e.g., when they are less nationalistic than patriotic. Both groups are of similar strength for patriotism and nationalism. The sources of national pride among the two groups are very similar and Praguers are those who can be labeled as being prouder in a few of the aspects of the Czech nation. The division between Praguers and non-Praguers seems to be rather artificial and based on inaccurate perceptions and/or interpretations.
A New Design of Large-format Streak Tube with Single-lens Focusing System
Authors: Tian Liping , Shen Lingbin , Chen Lin , Li Lili , Tian Jinshou , Chen Ping , Zhao Wei 
Published: October 2021

Abstract
Streak tubes with large-format and high spatial resolution are central to mm-spatial-resolved STIL detection system and hyperspectral resolved ICF experiment. In this paper, we established a large-format streak tube with a three-coaxial-cylindrical single-lens focusing system, a spherically curved photocathode and phosphor screen model in CST Particle Studio. The temporal and spatial resolution were calculated and mimicked based on the Monte-Carlo sampling method in static and dynamic mode. The simulated results show that the static spatial resolution reaches 50 lp/mm over the whole 50 mm effective photocathode length, and the physical temporal resolution is better than 45 ps. Furthermore, in dynamic working mode, the streak tube can achieve spatial resolution of 10 lp/mm and temporal resolution of 60 ps. The simulation results will be used to guide the design and production for large-format with high spatial resolution streak tube development.
Grief: Aetiology, Symptoms and Management
Authors: Pop-Jordanova Nada 
Published: October 2021

Abstract
Grief is a process provoked as a response to different losses, such as death, loss of job, relationship breakdown, some unexpected life events and changes, etc. The experiences of loss and bereavement are very individual. Even though loss is expected, the person feels traumatized, especially if death is provoked by violence, natural disasters, or war. This pandemic, like other disasters (wars, tsunami, earthquakes, floods, etc.) has provoked intensive reactions of grief, reactions that could persist for years. The core symptoms of grief are described in the ICD-11 and DSM-5 manuals.
The term “complicated grief” in the medical sense refers to a superimposed process that alters grief and modifies its course for the worse. Prolonged grief disorder (PGD) is characterized by normal grief symptoms, but these are symptoms that remain too intense for too long of a period.
This article is a review of the manifestations and duration of grief in different occasions, and it is based on over 50 published papers, and discoveries in the Medline and Psych-Net databases.
Commonly described reactions to grief are: shock, disbelief or denial, a high level of anxiety, distress, anger, sadness, insomnia, and a loss of appetite. As predictors for a high/slow decreasing trajectory of grief process are: female gender, reported symptoms of depression before the traumatic event, and higher scores on avoidance. However, grief is transient, even as we are is in the midst of its clutches. People should expect to fluctuate between moments of sadness and mourning, and moments of acceptance, or even happiness for being alive. Researchers suppose that when a crisis passes; most people will be able to bounce back and move on with their lives.
New DXA Diagnostic Indexes of Abdominal Obesity
Authors: Stratrova Slavica Shubeska , Mishevska Sasha Jovanovska , Efremovska Ljudmila , Bitoska Iskra , Spasovski Dejan 
Published: October 2021

Abstract

Aim: Cushing’s syndrome (CS) is associated with weight gain and extreme central, visceral, abdominal obesity which is confirmed with dual-energy X-rays absorptiometric (DXA) diagnostic cut-off point (CP) values of central obesity indexes (COI), determined as an android to gynoid tissue and fat mass ratios. These best differentiate CS from non-CS obese women matched with CS according to their age and BMI. The aim of this study was to determine the CP values of new DXA indexes of central, abdominal obesity as a ratio of android and trunk to legs as well as trunk and legs to total tissue and fat mass that best differentiate CS and matched non-CS obese women in order to confirm central abdominal obesity, and to determine their normal CP values that best differentiate healthy non-obese women from CS and non-CS obese women, and to exclude abdominal obesity completely.

Material and Methods: DXA indexes of abdominal obesity, calculated as а ratio of regional body fat and tissue mass compartments android to legs (A/L), trunk to legs (Tr/L), trunk to total (Tr/To) and legs to total (L/To) values were determined among 4 groups. Each group consisted of 18 women: 1st group of CS, 2nd group of obese women (O1) not different according to their age and BMI from CS, 3rd group of obese women (O2) with higher BMI of 35 ± 1.2 kg and a 4th group of non-obese, healthy women (C) with a normal BMI. Diagnostic accuracy (DG) of CP values of DXA indexes of abdominal obesity and indexes of normal body fat distribution (BFD) were determined.

Results: A/L, Tr/L, Tr/To, and L/To DXA indexes were significantly different between CS and O1 as well as between non-CS women O2 compared to O1 and C. These indexes had a highly significant correlation among each other and also in relation to their BMI (p < 0.0001). A/L-Tm CP value of 0.3 best differentiated the CS from group O1, with the highest DG of 100 % and an A/L-Fm CP value of 0.26 differentiated them with a DG of 94.44% and sensitivity of 100 %. An A/L-Tn CP value of 0.23 and an A/L-Fn CP value of 0.25 best differentiated CS and C as well as O2 and C for the highest DG of 100 %.

Conclusions: DXA indexes A/L, Tr/L, Tr/To and L/To values were significantly different among the four groups. These values correlated significantly among them and with their BMI in non-CS groups, thus confirming a BMI increase association with a more pronounced abdominal BFD. An A/L-Tm CP value of 0.3 and an A/L-Fm CP value of 0.26 were discovered as the best DXA diagnostic indexes of extreme abdominal obesity in CS and these could also be used in discovering abdominal BFD in non-CS obese women with metabolic syndrome (MS). An A/L-Tn CP value of 0.23 and an A/L-Fn CP value of 0.25 were discovered as the best DXA diagnostic indexes of normal BFD which completely excluded abdominal obesity.