bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Distress and Sleep Disturbance Throughout Thyroid Nodule Screening, Diagnosis, and Treatment
Authors: Li Ruicen , Li Genpeng , Wang Yuting , Bao Ting , Lei Yali , Tian Liuyan , Li Zhihui , Zhu Jingqiang , Lei Jianyong , Tang Huairong 
Published: April 2021

Abstract

Context
Many controversies exist regarding screening and treatment of thyroid cancer (TC), especially papillary thyroid microcarcinoma (PTMC).

Objective
The aim of this study was to evaluate patients’ psychological distress and sleep disturbance throughout thyroid nodule (TN) screening, diagnosis, and treatment.

Methods
A total of 2834 participants (1153 participants with TNs) were enrolled during the screening phase, and 1105 individuals with TNs (87 individuals with TC) were enrolled during the diagnosis phase. Of the 87 TC patients, 66 underwent immediate operation (OP), and 21 patients with PTMC opted for active surveillance (AS). Four validated scales were applied to quantify the outcome indicators at prescreening, postscreening, postdiagnosis, and posttreatment.

Results
Higher psychological distress and sleep disturbance were found postscreening than prescreening in subjects with TNs, but no differences in those without nodules. Compared with postscreening, higher scores of psychological distress and sleep disturbance were identified in patients with suspicious TC treated with fine needle aspiration (FNA) or with AS. Lower psychological distress and sleep disturbance were noted for patients with benign nodules than for TC patients. OP for TC, especially PTMC, did not alleviate psychological distress or sleep disturbance compared with the same parameters in patients who underwent AS.

Conclusion
Based on the findings of impaired psychological health and sleep quality, screening for TNs in adults who show no symptoms should be performed with caution. Psychological distress and sleep disturbance should also be taken into consideration when FNA is performed for suspected TC or OP for papillary thyroid cancer, especially PTMC.
Differences in critical thinking skills between nursing students on a fast-track versus traditional 4-year programme
Authors: Aldiabat Khaldoun , Alsrayheen Enam , Aquino-Russell Catherine , Al-Qadire Mohammad , Al Rawajfah Omar , Al Sabei Sulaiman Dawood 
Published: April 2021

Background: The authors were unable to find studies comparing the critical thinking skills of nursing students on advanced standing programmes (ASP) and on traditional 4-year BN programmes in Canada. The ASP is a condensed Bachelor of Nursing (BN) programme, designed for students who already have a university degree or similar qualification. Aim: To measure and compare the critical thinking skills of ASP students and traditional 4-year BN students. Method: A cross-sectional study using a self-administered questionnaire used to collect data from 100 nursing students at a university in Canada. Data were analysed using descriptive and inferential statistics. All research ethics were taken into consideration. Findings: All participants scored highly in their critical thinking skills. However, ASP students scored significantly higher than their counterparts on the 4-year programme (M=21.6 vs M=18.9, F=4.75, P=0.035). Conclusion: Higher critical thinking skills among ASP nursing students is a promising sign to expand and support this type of programme as a fast and effective method to cover the shortage in nurses.
Dielectric perturbations: anomalous resonance frequency shifts in optical resonators
Authors: Azeem Farhan , Trainor Luke S. , Devane Patrick A. , Norman Daniel S. , Rueda Alfredo , Lambert Nicholas J. , Kumari Madhuri , Foreman Matthew R. , Schwefel Harald G. L. 
Published: April 2021

Small perturbations in the dielectric environment around resonant dielectric structures usually lead to a frequency shift of the resonator modes directly proportional to the polarizability of the perturbation. Here, we report experimental observations of strong frequency shifts that can oppose and even exceed the contribution of the perturbations’ polarizability. We show in particular how the mode frequencies of a lithium niobate whispering-gallery-mode resonator are shifted by planar substrates—of refractive indices ranging from 1.50 to 4.22—contacting the resonator rim. Both blue- and redshifts are observed, as well as an increase in mode linewidth, when substrates are moved into the evanescent field of the whispering gallery mode. We compare the experimental results to a theoretical model by Foreman et al. [J. Opt. Soc. Am. B 33, 2177 (2016)JOBPDE0740-322410.1364/JOSAB.33.002177] and provide an additional intuitive explanation based on the Goos–Hänchen shift for the optical domain, with applications to dielectric structures ranging from meta-surfaces to photonic crystal cavities.
Terahertz optical Hall effect in p-type monolayer hexagonal boron nitride on fused silica substrate
Authors: Bilal Muhammad , Xu Wen , Wen Hua , Cheng Xingjia , Xiao Yiming , Ding Lan 
Published: April 2021

We demonstrate for the first time, to the best of our knowledge, that the optical Hall effect (OHE) can be observed in p-type monolayer (ML) hexagonal boron nitride (hBN) on a fused silica substrate by applying linearly polarized terahertz (THz) irradiation. When ML hBN is placed on fused silica, in which the incident pulsed THz field can create local and transient electromagnetic dipoles, proximity-induced interactions can be presented. The Rashba spin–orbit coupling can be enhanced, and the in-plane spin component can be induced, along with the lifting of valley degeneracy. Thus, in the presence of linearly polarized THz radiation, the nonzero transverse optical conductivity (or Hall conductivity) can be observed. We measure the THz transmission through ML hBN/fused silica in the temperature range from 80 to 280 K by using THz time-domain spectroscopy in combination with an optical polarization examination. The Faraday ellipticity and rotation angle, together with the complex longitudinal and transverse conductivities, are obtained. The temperature dependence of these quantities is examined. The results obtained from this work indicate that ML hBN is a valleytronic material, and proximity-induced interactions can lead to the observation of OHE in the absence of an external magnetic field.
Localized tilted fiber Bragg gratings induced by femtosecond laser line-by-line inscription
Authors: Liu Bonan , Yang Kaiming , Liao Changrui , Cai Zhihao , Liu Yifan , Sun Bing , Wang Yiping 
Published: April 2021

Localized tilted fiber Bragg gratings (TFBGs) with low insertion loss are reported. A series of second-order TFBGs with tilt angles of 0°, 7°, 14°, and 21° was inscribed line by line directly in a single-mode fiber. For the 7° TFBG, the Bragg resonance was 2.4 dB at 1550 nm, and the maximum cladding-mode resonance reached 24.6 dB with an insertion loss of 0.8 dB, the same level as that for TFBGs fabricated by the phase-mask method. The range in cladding-mode resonance for the TFBGs obtained was wider than 170 nm with an intensity exceeding 20 dB. Combined with microscope images, the formation of these localized TFBGs and their spectral performance are discussed. The effect of an inscription offset along the

y

-axis direction was further investigated. With increasing offset, the intensity of the cladding-mode resonance dropped rapidly. The refractive index response sensitivity of the 7° TFBG was measured at 507.54 nm/RIU.
Investigating the procurement system for understanding seasonal influenza vaccine brand availability in Europe
Authors: Stuurman Anke L. , Rizzo Caterina , Haag Mendel 
Published: April 2021

Background
Timely knowledge of which influenza vaccine brands are procured and where is of interest to inform site-selection for brand-specific influenza vaccine effectiveness (VE) studies. Vaccine procurement is a key determinant of brand availability. We therefore sought to understand how the procurement for seasonal influenza vaccine in Europe is organized, how this drives brand availability and how procurement data could enable to determine brand availability pre-season.

Methods
Structured telephone interviews were conducted with 15 experts in 16 European countries between 2017 and 2019 to collect information on the influenza vaccine procurement systems. Sources of (brand-specific) procurement data were identified and assessed on public accessibility. Vaccine type and brand availability and timelines were determined for the 2019–20 season to understand how procurement systems drive brand availability and diversity.

Results
Four main types of procurement systems for seasonal influenza vaccination campaigns were identified: national public tenders (Croatia, Denmark, Finland, Ireland, Lithuania, Netherlands, Norway, Scotland, Slovenia), regional public tenders (Italy, Spain, Sweden), direct purchase of vaccines by GPs (England, Wales) or pharmacies (Belgium, France, Germany, Greece) from manufacturers or wholesalers. National public tender outcomes are publicly available and timely; brand availability at clinic level can generally be deduced or narrowed down to two brands. Regional tender outcomes are more difficult to find, known very late or not available. In Italian and Spanish regions tenders may be awarded only a few weeks before the seasonal campaign. No public procurement information is available for countries with direct purchase.

Conclusion
At the country-level, brand diversity is generally lower for countries with national public tenders than for countries with regional public tenders or direct purchase. In only a few countries, procurement data at the brand level is both publicly available and timely. Therefore the usefulness of procurement data for prospective site-selection for brand-specific VE studies is limited.
Hematological and CD4+ T- cell count reference interval for pregnant women attending antenatal care at Hawassa University Comprehensive Specialized Hospital, Hawassa Southern Ethiopia
Authors: Gebere Yidnekachew Fiseha , Bimerew Lealem Gedefaw , Malko Wondimagegn Adissu , Fenta Demissie Assegu 
Published: April 2021

Background
Pregnancy is a state characterized by physiological, hematological, and immunological changes. However, the reference intervals (RI) being used in clinical practice in Ethiopia are derived from non-local general populations. Therefore; this study was aimed to determine the reference interval of hematological and immunological profiles among healthy pregnant mothers attending Hawassa University Hospital.

Methods
A cross-sectional study in a total of 360 healthy pregnant women was enrolled from January to April 2019, at Hawassa University hospital. Sociodemographic and obstetric data were collected using a structured questionnaire. Blood samples collected from each participant were used to define the hematological parameters. The median and 95% intervals were calculated for the immunological and hematological profiles. P-value 0.05 was considered statistically significant.

Result
A total of 360 healthy pregnant women were enrolled in this study. The age range of the participants was 18–45 years. 342(95%) were married and 270 (75%) of the participants were multigravida. The overall median CD4+ T-cell and total WBC counts (cells/mm3) were 602 and 7.58 respectively. The overall median value for lymphocytes, neutrophils, monocytes, eosinophils, and basophil count was (cells/mm3) was 2.21, 6.74, .63, .53, and 0.09 respectively. Whereas the median RBC and platelet count was 4.48×106/μLand 212×106/μL. The median value of hematological profiles in the first, second, and third trimesters was TWBC (103/μL) (7.90, 8.30, 8.65), RBC (106/μL) (4.5, 4.6, 4.62), and PLT (103/μL) (210, 209,161) respectively. The CD4 T cell count median value was (600, 598, and 591) in the first, second, and third trimesters. Significant changes were observed in hematological and immunological parameters between trimesters (P < 0.05).

Conclusion
Significant changes were observed in hematological and immunological parameters between trimesters (P < 0.05). Considerable differences were also seen between the values in this study and other studies from Ethiopia and other countries, indicated the need for the development of local reference intervals for pregnant women.
The school policy, social, and physical environment and change in adolescent physical activity: An exploratory analysis using the LASSO
Authors: Foubister Campbell , van Sluijs Esther M. F. , Vignoles Anna , Wilkinson Paul , Wilson Edward C. F. , Croxson Caroline H. D. , Brown Helen Elizabeth , Corder Kirsten 
Published: April 2021

Purpose
We examined the association between the school policy, social and physical environment and change in adolescent physical activity (PA) and explored how sex and socioeconomic status modified potential associations.

Methods
Data from the GoActive study were used for these analyses. Participants were adolescents (n = 1765, mean age±SD 13.2±0.4y) from the East of England, UK. Change in longitudinal accelerometer assessed moderate-to-vigorous physical activity (MVPA) was the outcome. School policy, social and physical environment features (n = 267) were exposures. The least absolute shrinkage and selection operator variable selection method (LASSO) was used to determine exposures most relevant to the outcome. Exposures selected by the LASSO were added to a multiple linear regression model with estimates of change in min/day of MVPA per 1-unit change in each exposure reported. Post-hoc analyses, exploring associations between change in variables selected by the LASSO and change in MVPA, were undertaken to further explain findings.

Findings
No school policy or physical environment features were selected by the LASSO as predictors of change in MVPA. The LASSO selected two school social environment variables (participants asking a friend to do physical activity; friend asking a participant to do physical activity) as potential predictors of change in MVPA but no significant associations were found in subsequent linear regression models for all participants (β [95%CI] -1.01 [-2.73;0.71] and 0.65 [-2.17;0.87] min/day respectively). In the post-hoc analyses, for every unit increase in change in participants asking a friend to do PA and change in a friend asking participants to do PA, an increase in MVPA of 2.78 (1.55;4.02) and 1.80 (0.48;3.11) min/day was predicted respectively.

Conclusions
The school social environment is associated with PA during adolescence. Further exploration of how friendships during adolescence may be leveraged to support effective PA promotion in schools is warranted.
What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak
Authors: Mehta Monica , Purpura Lawrence J. , McConville Thomas H. , Neidell Matthew J. , Anderson Michaela R. , Bernstein Elana J. , Dietz Donald E. , Laracy Justin , Gunaratne Shauna H. , Miller Emily Happy , Cheng Jennifer , Zucker Jason , Shah Shivang S. , Chaudhuri Shaoli , Gordillo Christian A. , Patel Shreena R. , Guo Tai Wei , Karaaslan Lara E. , Reshef Ran , Miko Benjamin A. , Bathon Joan M. , Pereira Marcus R. , Uhlemann Anne-Catrin , Yin Michael T. , Sobieszczyk Magdalena E. 
Published: April 2021

Background
Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent of corticosteroids remains unclear in patients with severe disease.

Methods
In this retrospective analysis of patients with COVID-19 admitted between March 2 and April 14, 2020 to a large academic medical center in New York City, we describe outcomes associated with tocilizumab 400 mg (without methylprednisolone) compared to a propensity-matched control. The primary endpoints were change in a 7-point ordinal scale of oxygenation and ventilator free survival, both at days 14 and 28. Secondary endpoints include incidence of bacterial superinfections and gastrointestinal perforation. Primary outcomes were evaluated using t-test.

Results
We identified 33 patients who received tocilizumab and matched 74 controls based on demographics and health measures upon admission. After adjusting for illness severity and baseline ordinal scale, we failed to find evidence of an improvement in hypoxemia based on an ordinal scale at hospital day 14 in the tocilizumab group (OR 2.2; 95% CI, 0.7–6.5; p = 0.157) or day 28 (OR 1.1; 95% CI, 0.4–3.6; p = 0.82). There also was no evidence of an improvement in ventilator-free survival at day 14 (OR 0.8; 95% CI, 0.18–3.5; p = 0.75) or day 28 (OR 1.1; 95% CI, 0.1–1.8; p = 0.23). There was no increase in secondary bacterial infection rates in the tocilizumab group compared to controls (OR 0.37; 95% CI, 0.09–1.53; p = 0.168).

Conclusions
There was no evidence to support an improvement in hypoxemia or ventilator-free survival with use of tocilizumab 400 mg in the absence of corticosteroids. No increase in secondary bacterial infections was observed in the group receiving tocilizumab.
A Swept source optical coherence tomography angiography study: Imaging artifacts and comparison of non-perfusion areas with fluorescein angiography in diabetic macular edema
Authors: Podkowinski Dominika , Beka Sophie , Mursch-Edlmayr Anna-Sophie , Strauss Rupert W. , Fischer Lukas , Bolz Matthias 
Published: April 2021

Purpose
Swept Source Optical coherence tomography angiography (SS-OCTA) is a novel technique to visualize perfusion and vascular changes like ischemia in patients with diabetic retinopathy. The aim of this study was to compare non-perfusion areas on conventional fluorescein angiography (FA) with those on SS-OCTA using detailed manual annotation in patients with diabetic macular edema (DME) and to evaluate possible artifacts caused by DME on SS-OCTA.

Methods
27 eyes of 21 patients with DME were analyzed in this prospective, cross-sectional study; on all, standard ophthalmological examination, SS-OCTA and FA imaging were performed. Early-phase FA and SS-OCTA images were analyzed for capillary dropout and foveal avascular zone (FAZ) was measured on both modalities. Artifacts in SS-OCTA imaging caused by DME were marked and analyzed.

Results
The mean age of the patients was 62.6 ± 11.5 years. On FA the mean size of the annotated non-perfusion areas was 0.14 ± 0.31 mm2 whereas the mean size in SS-OCTA was 0.04 ± 0.13 mm2; areas marked on FA were statistically significantly larger than on SS-OCTA (p<0.01). Mean size of FAZs was similar between FA and OCTA images. (p = 0.91). Seven eyes (25.9 percent) showed imaging artifacts due to DME in SS-OCTA.

Conclusion
SS-OCTA is a valid tool to analyze capillary perfusion status of patients with DME, although areas of non-perfusion were measured smaller than in conventional FA. More non-perfusion areas were found on SS-OCTA images. FAZ measurements were similar using the two modalities. However, SS-OCTA is prone to artifacts and therefore requires reviewing of imaging results: up to 25 percent of the analyzed eyes showed artifacts on OCTA, which occurred in the areas of diabetic macular edema and did not correspond to capillary drop out.
Dis/Graceful Liberties: Textual Libertinism/ Libertine Texts in J.M. Coetzee’s Disgrace
Authors: Driss Hager Ben 
Published: April 2021

AbstractThis essay addresses J.M. Coetzee’s Disgrace, a Booker Prize winner in 1999. The novel captures South African political and cultural turmoil attending the post-apartheid transitional period. Far from overlooking the political allegory, I propose instead to expand on a topic only cursorily developed elsewhere, namely liberty and license. The two terms foreground the textual dynamics of the novel as they compete and/or negotiate meaning and ascendency. I argue that Disgrace is energized by Coetzee’s belief in a total liberty of artistic production. Sex is philosophically problematized in the text and advocated as a serious issue that deserves artistic investigation without restriction or censorship. This essay looks into the subtle libertinism in Coetzee’s text, which displays pornographic overtones without exhibiting a flamboyant libertinage. Disgrace acquires its libertine gesture from its dialogue with several literary works steeped in libertinism. The troubled relationship between the aesthetic and the ethical yields an ambiguous text that invites a responsible act of reading.
“Nobody gets out alive. This place just a big coffin”: On Death and Dying in American Prisons
Authors: Andreescu Raluca 
Published: April 2021

AbstractThis article explores the manner in which the narratives in the Prison Noir volume (2014) edited by Joyce Carol Oates bring into view the limits and abusive practices of the American criminal justice system within the confines of one of its most secretive sites, the prison. Taking an insider’s perspective - all stories are written by award-winning former or current prisoners - the volume creates room for the usually silent voices of those incarcerated in correctional facilities throughout the United States. The article engages the effects of “prisonization” and the subsequent mortification of inmates by focusing on images of death and dying in American prisons, whether understood as a ‘social death,’ the isolation from any meaningful intercourse with society, as a ‘civil death,’ the stripping away of citizenship rights and legal protections, or as the physical termination of life as a result of illness, murder, suicide or statesponsored execution.
“Ava’s body is a good one”: (Dis)Embodiment in Ex Machina
Authors: Henke Jennifer 
Published: April 2021

Abstract
This article discusses the role of the body in Alex Garland’s film Ex Machina (2015). It focuses on Ava’s female cyborg body against the backdrop of both classic post-humanist theories and current reflections from scholars in the field of body studies. I argue that Ex Machina addresses but also transcends questions of gender and feminism. It stresses the importance of the body for social interaction both in the virtual as well as the real world. Ava’s lack of humanity results from her mind that is derived from the digital network Blue Book in which disembodied communication dominates. Moreover, the particular construction of Nathan’s progeny demonstrates his longing for a docile sex toy since he created Ava with fully functional genitals but without morals. Ex Machina further exhibits various network metaphors both on the visual and the audio level that contribute to the (re)acknowledgement that we need a body in order to be human.
Pleasure, Judgment and the Function of the Painter-Scribe Analogy
Authors: Fletcher Emily 
Published: April 2021

AbstractThis paper puts forward a new interpretation of the argument atPhilebus36c–40d that pleasures can be false. Protarchus raises an objection at 37e–38a, and in response Socrates presents the elaborate painter-scribe analogy (38e–40c). Most previous interpretations do not explain how the analogy answers Protarchus’ objection. On my account, Protarchus’ objection relies on the plausible intuition that pleasure is simply not in the business of assessing the world, and so it cannot be charged with doing so incorrectly. Socrates responds by demonstrating that pleasure can be mistaken about the world, despite not making an independent assessment of it. The painter-scribe analogy demonstrates how pleasure comes to be mistaken about the world by reproducing the mistake of a judgment. Socrates persuades Protarchus that pleasure can be mistaken in part by preserving his intuition that pleasure itself is not the source of the mistake.