bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic impact of spectral body imaging in diagnosis of patients suspected for occult cancer
Authors: Andersen Michael Brun , Ebbesen Dyveke , Thygesen Jesper , Kruis Matthijs , Gu Qing , Dharaiya Ekta , Rasmussen Finn 
Published: December 2021

Abstract
Background
Based on prior studies spectral CT has shown a higher sensitivity for malignant lesions than conventional CT at the cost of lower specificity. For the radiologists, it also offers a higher degree of certainty in the diagnosis of benign lesions. The objective of this study was to evaluate the economic impact of spectral CT in patients suspected of occult cancer in a medical center in Denmark.

Methods
This study was a secondary analysis using de-identified data from a prospective study of patients receiving a contrast-enhanced spectral CT scan. Based on suggested follow-up examinations on both spectral CT and contrast-enhanced CT, costs from a payer’s perspective were determined using unit costs obtained from national databases.

Results
The dataset contained 400 patients. Overall, 203 follow-up procedures were eliminated based on spectral data reading. The largest reduction in suggested follow-up procedures was found for the kidney (83%), followed by the liver (66%), adrenal glands (60%), and pancreas (42%). The total estimated costs for suggested follow-up procedures based on spectral data reading were €155,219, 25.2% (€52,384) less than that of conventional CT reading.

Conclusion
Our results provide support for spectral body imaging as an advanced imaging modality for suspected occult cancer. A substantial number of follow-up diagnostic procedures could be eliminated based on spectral data reading, which would result in significant cost savings.
Portomesenteric venous thrombosis in a prophylactically anticoagulated obese patient after laparoscopic sleeve gastrectomy: a case report
Authors: Alsannaa Feras , Albaqami Faisal , Shalhoub Mishary 
Published: December 2021

Abstract
Background
Obesity is associated with an increased risk of morbidity and mortality, so weight reduction is important. Bariatric surgery is a well-tolerated approach for reducing body weight, with laparoscopic sleeve gastrectomy commonly performed. An uncommon and potentially fatal sequela of laparoscopic sleeve gastrectomy is portomesenteric vein thrombosis, which may result in severe bowel ischemia.

Case report
A 32-year-old Middle Eastern obese man (body mass index 33) presented to the emergency department with severe, generalized abdominal pain 2 weeks after laparoscopic sleeve gastrectomy. Computed tomography of the abdomen and pelvis revealed extensive acute on chronic portosplenic and superior mesenteric vein thrombosis with associated small bowel ischemia. Laparoscopic exploration was converted to midline laparotomy and an extensive ischemic small bowel resection.

Conclusion
Laparoscopic sleeve gastrectomy carries a risk of both morbidity and mortality. Venous thromboembolism is a well-known risk of bariatric surgery, but portomesenteric vein thrombosis is also a rare but sometimes serious complication. A high index of suspicion for portomesenteric vein thrombosis to prompt early detection is essential in patients who have undergone laparoscopic sleeve gastrectomy to minimize complications and optimize outcomes. Uncertainty still remains around the optimal dose and duration of anticoagulation after laparoscopic sleeve gastrectomy.
A historical vertebrate collection from the Middle Miocene of the Peruvian Amazon
Authors: Carrillo-Briceño Jorge D. , Aguilera Orangel A. , Benites-Palomino Aldo , Hsiou Annie S. , Birindelli José L. O. , Adnet Sylvain , Cadena Edwin-Alberto , Scheyer Torsten M. 
Published: December 2021

AbstractThe Miocene aquatic and terrestrial fossil record from western Amazonia constitute a clear evidence of the palaeoenvironmental diversity that prevailed in the area, prior to the establishment of the Amazon River drainage. During the Miocene, the region was characterized by a freshwater megawetland basin, influenced by episodic shallow-marine incursions. A fossil vertebrate collection from the middle Miocene strata of the Pebas Formation is here studied and described. This historical collection was recovered in 1912 along the banks of the Itaya River (Iquitos, Peru), during a scientific expedition led by two scientists of the University of Zurich, Hans Bluntschli and Bernhard Peyer. Our findings include a total of 34 taxa, including stingrays, bony fishes, turtles, snakes, crocodylians, and lizards. Fishes are the most abundant group in the assemblage (~ 23 taxa), including the first fossil record of the freshwater serrasalmids Serrasalmus, and Mylossoma, and the hemiodontid Hemiodus for the Pebas system, with the latter representing the first fossil be discovered for the entire Hemiodontidae. The presence of a representative of Colubroidea in the middle Miocene of Iquitos supports the hypothesis of arrival and dispersal of these snakes into South America earlier than previously expected. This fossil assemblage sheds light on the palaeoenvironments, and the geographical/temporal range of several aquatic/terrestrial lineages inhabiting the Amazonian region.
Novel insights into early life stages of finned octopods (Octopoda: Cirrata)
Authors: Ziegler Alexander , Miller Abigail , Nagelmann Nina 
Published: December 2021

AbstractThe finned or dumbo octopods (Octopoda: Cirrata) constitute a cephalopod (Mollusca: Cephalopoda) taxon almost exclusively comprising organisms that inhabit the deep-sea. This renders studying the general biology of adult cirrate specimens a difficult task, but even more so when it comes to gathering knowledge on their early life stages. During his comprehensive research exploits on cephalopod development, the late Sigurd von Boletzky (1942–2020) also sought to shed light on specific adaptations that eggs and embryos of these enigmatic deep-sea octopods might show. Based on his seminal work, the present article sets out to provide additional data on a broad range of early cirrate life stages, including egg capsules without any obvious embryonic stage as well as those containing embryos. These previously unreported specimens obtained from museum collections were analyzed using conventional morphological as well as modern three-dimensional imaging techniques. The present overview includes specimens from four of the five oceans, i.e., the Atlantic, Pacific, Indian, and Southern Ocean. Based on information on cirrate ovum, chorion, and egg capsule size as well as shape gathered from the literature, an attempt is made here for the first time to identify von Boletzky's as well as the specimens introduced here down to at least genus level. The combined data provide novel insights into early life stages of finned octopods, aiming to continue von Boletzky's legacy with regard to developmental research on a still largely enigmatic taxon of extant deep-sea cephalopods.
Instantaneous cross-correlation function type of WD based LFM signals analysis via output SNR inequality modeling
Authors: Qiang Sheng-Zhou , Jiang Xian , Han Pu-Yu , Shi Xi-Ya , Wu An-Yang , Sun Yun , Chen Yun-Jie , Zhang Zhi-Chao 
Published: December 2021

AbstractLinear canonical transform (LCT) is a powerful tool for improving the detection accuracy of the conventional Wigner distribution (WD). However, the LCT free parameters embedded increase computational complexity. Recently, the instantaneous cross-correlation function type of WD (ICFWD), a specific WD relevant to the LCT, has shown to be an outcome of the tradeoff between detection accuracy and computational complexity. In this paper, the ICFWD is applied to detect noisy single component and bi-component linear frequency-modulated (LFM) signals through the output signal-to-noise ratio (SNR) inequality modeling and solving with respect to the ICFWD and WD. The expectation-based output SNR inequality model between the ICFWD and WD on a pure deterministic signal added with a zero-mean random noise is proposed. The solutions of the inequality model in regard to single component and bi-component LFM signals corrupted with additive zero-mean stationary noise are obtained respectively. The detection accuracy of ICFWD with that of the closed-form ICFWD (CICFWD), the affine characteristic Wigner distribution (ACWD), the kernel function Wigner distribution (KFWD), the convolution representation Wigner distribution (CRWD) and the classical WD is compared. It also compares the computing speed of ICFWD with that of CICFWD, ACWD, KFWD and CRWD.
On compositions of special cases of Lipschitz continuous operators
Authors: Giselsson Pontus , Moursi Walaa M. 
Published: December 2021

AbstractMany iterative optimization algorithms involve compositions of special cases of Lipschitz continuous operators, namely firmly nonexpansive, averaged, and nonexpansive operators. The structure and properties of the compositions are of particular importance in the proofs of convergence of such algorithms. In this paper, we systematically study the compositions of further special cases of Lipschitz continuous operators. Applications of our results include compositions of scaled conically nonexpansive mappings, as well as the Douglas–Rachford and forward–backward operators, when applied to solve certain structured monotone inclusion and optimization problems. Several examples illustrate and tighten our conclusions.
A social perspective on resilience: social support and dyadic coping in teacher training
Authors: Kärner Tobias , Weiß Julia Katharina , Heinrichs Karin 
Published: December 2021

AbstractStress in teaching and teacher training is a well-known issue and stress management during teacher training may not only be affected by individual coping efforts, but also determined by private and work-related networks the individual is integrated in. In that regard, our article aims firstly to identify sources of social support in the German teacher training system and secondly to analyze interdependencies in dyadic coping interactions based on the Actor-Partner Interdependence Model. On the basis of questionnaire data from 307 German trainees and qualified teachers from vocational and general schools, we found that mentors, partners, fellow trainees, colleagues at school, parents, and good friends were named as the most supportive reference persons during teacher training. In a follow-up survey, data from 49 sources of support were obtained, which could be assigned to the corresponding (trainee) teachers (in the sense of support recipients). These dyads thus form the basis for the analysis of dyadic coping interdependencies. The results of the moderator analyses show, among other things, that support recipients who prefer the coping strategy palliative emotion regulation tend to react rather sensitively to contrary coping strategies of the source of support with regard to their stress symptoms. Social interactions in this respect can represent both protective as well as risk factors. Therefore, a system of complex social interdependencies must be considered when analyzing relational resilience among prospective teachers.
Ultrafiltration in Japanese critically ill patients with acute kidney injury on renal replacement therapy
Authors: Kitamura Koichi , Hayashi Koichi , Fujitani Shigeki , Murugan Raghavan , Suzuki Toshihiko 
Published: December 2021

AbstractA recent worldwide survey indicates an international diversity in net ultrafiltration (UFNET) practices for the treatment of fluid overload in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT). The sub-analysis of the survey has demonstrated that maximum doses of furosemide used before determination of diuretic resistance are lower in Japan than those prescribed worldwide and UFNET is lower but is initiated earlier. In contrast, the interval during which practitioners evaluate fluid balance is longer. The characterization of RRT in critically ill patients in Japan should unveil more appropriate approaches to the successful treatment of AKI.
Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
Authors: Mitsuyama Yumi , Yamakawa Kazuma , Kayano Katsuhide , Maruyama Miho , Wada Takeshi , Fujimi Satoshi 
Published: December 2021

AbstractWe evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymphocyte counts but did show abundant CD8-positive T lymphocytes. CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B were more abundant in post-recovery patients. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19.
LiDAR DNN based self-attitude estimation with learning landscape regularities
Authors: Ozaki Ryota , Sugiura Naoya , Kuroda Yoji 
Published: December 2021

AbstractThis paper presents an EKF (extended Kalman filter) based self-attitude estimation method with a LiDAR DNN (deep neural network) learning landscape regularities. The proposed DNN infers the gravity direction from LiDAR data. The point cloud obtained with the LiDAR is transformed to a depth image to be input to the network. It is pre-trained with large synthetic datasets. They are collected in a flight simulator because various gravity vectors can be easily obtained, although this study focuses not only on UAVs. Fine-tuning with datasets collected with real sensors is done after the pre-training. Data augmentation is processed during the training in order to provide higher general versatility. The proposed method integrates angular rates from a gyroscope and the DNN outputs in an EKF. Static validations are performed to show the DNN can infer the gravity direction. Dynamic validations are performed to show the DNN can be used in real-time estimation. Some conventional methods are implemented for comparison.
Current state and future prospects of pure mycelium materials
Authors: Vandelook Simon , Elsacker Elise , Van Wylick Aurélie , De Laet Lars , Peeters Eveline 
Published: December 2021

AbstractIn the context of the ongoing transition from a linear to a circular economy, ecologically friendly renewable solutions are put in place. Filamentous fungi can be grown on various organic feedstocks and functionalized into a range of diverse material types which are biobased and thus more sustainable in terms of their production, use and recycling. Pure mycelium materials, consisting only of mycelial biomass, can adopt versatile properties and appear promising as a substitute for current petrochemically produced polymeric materials or, in the case of myco-leather, as a substitute for animal-based leather. In recent years, a handful of private companies have been innovating to bring products based on pure mycelium materials to the market while scientific interest in these promising biomaterials is now starting to gain momentum. In this primer, we introduce pure mycelium materials, frame different production methods, review existing and potential future applications, thereby offering a vision on future advances for this emerging fungi-based technology.
Distal gastric tube resection with preservation of the right gastroepiploic artery for gastric tube cancer: a case report
Authors: Tajima Kohei , Shimada Hideo , Nishi Takayuki , Kamei Yutaro , Koyanagi Kazuo , Makuuchi Hiroyasu 
Published: December 2021

Abstract
Background
The incidence of gastric tube cancer is increasing because of improved survival rates in patients with esophageal cancer treated by esophagectomy. Total resection of the gastric tube is expected to be highly curative, but it is associated with a higher risk of severe postoperative complications. Herein we report a case of early gastric tube cancer that was successfully treated by distal gastric tube resection with preservation of the right gastroepiploic artery (RGEA).

Case presentation
An 82-year-old man was diagnosed as having gastric tube cancer, B-12-O, Type 0-IIc, T1b, N0, M0, cStage IA (Japanese Classification of Gastric Carcinoma). Upper gastrointestinal endoscopy showed a Type 0-IIc lesion measuring 30 mm in length in the lower part of the gastric tube, and histopathological examination of biopsy specimens revealed the features of poorly differentiated adenocarcinoma. The primary lesion could not be identified by computed tomography, and there was no obvious lymph node metastasis or distant metastasis. Considering that total resection of the gastric tube would have been highly invasive and that the gastric tube cancer was at a relatively early stage, we performed distal gastric tube resection with preservation of the RGEA. The postoperative course was uneventful, and the patient was discharged on postoperative day 12. There has been no recurrence during the 17 months of follow-up.

Conclusion
We successfully treated a patient with gastric tube cancer by distal gastric tube resection with preservation of the RGEA. This treatment strategy may be acceptable for patients with early gastric tube cancer without lymph node metastasis, considering the balance between the surgical invasiveness and curability of the tumor.
Hypothyroidism and hypopituitarism as immune-related adverse events due to lenvatinib plus pembrolizumab therapy in the immediate postoperative period after laparoscopic hepatectomy for liver metastases from gastric cancer: a case report
Authors: Sasaki Kimimasa , Kobayashi Shin , Kudo Masashi , Sugimoto Motokazu , Takahashi Shinichiro , Nakamura Yoshiaki , Kawazoe Akihito , Shitara Kohei , Kinoshita Takahiro , Gotohda Naoto 
Published: December 2021

Abstract
Background
Immune checkpoint inhibitors (ICIs) are emerging agents used for the treatment of various malignant tumors. As ICIs are generally used for unresectable malignant tumors, there have been only a few reports of patients who underwent surgery after receiving these drugs. Therefore, it remains unclear how immune-related adverse events (irAEs) affect the postoperative course. Here, we report a patient with advanced gastric cancer who underwent laparoscopic hepatectomy for liver metastases after an objective response with lenvatinib plus pembrolizumab and developed hypothyroidism and hypopituitarism as irAEs in the immediate postoperative period.

Case presentation
A 73-year-old man had undergone total gastrectomy for pT4aN2M0 gastric cancer followed by adjuvant chemotherapy with S-1 and docetaxel, and developed liver metastases in segments 6 and 7. He was enrolled in phase 2 clinical trial of lenvatinib plus pembrolizumab. He continuously achieved a partial response with the study treatment, and the liver metastases were decreased in size on imaging. The tumors were judged to be resectable and the patient underwent laparoscopic partial hepatectomy for segments 6 and 7. From the 1st postoperative day, the patient continuously presented with fever and general fatigue, and his fasting blood glucose level remained slightly lower than that before the surgery. On the 4th postoperative day, laboratory examination revealed hypothyroidism and hypopituitarism, which were suspected to be irAE caused by lenvatinib plus pembrolizumab after surgery. He received hydrocortisone first, followed by levothyroxine after adrenal insufficiency was recovered. Subsequently, his fever, general fatigue, and any abnormality regarding fasting blood glucose level resolved, and he was discharged on the 12th postoperative day. After discharge, his laboratory data for thyroid and pituitary function remained stable while receiving hydrocortisone and levothyroxine without recurrence of gastric cancer.

Conclusion
We present a case of laparoscopic hepatectomy after receiving lenvatinib plus pembrolizumab and developed hypothyroidism and hypopituitarism after surgery. Regarding surgery after ICI therapy, it is important to recognize that irAEs might occur in the postoperative period.
Damage control surgery for grade IV blunt hepatic injury with multiple organ damage in a child: a case report
Authors: Soma Jun , Ishii Daisuke , Miyagi Hisayuki , Ishii Seiya , Motoki Keita , Kawabata Hidemasa , Ishitoya Shunta , Hagiwara Masahiro , Kokita Naohiro , Hirasawa Masatoshi 
Published: December 2021

Abstract
Background
Intra-abdominal hemorrhage caused by blunt hepatic injury is a major cause of morbidity and mortality in patients with abdominal trauma. Some of these patients require laparotomy, and rapid decision-making and life-saving surgery are essential. Damage control (DC) surgery is useful for treating children in critical situations. We performed this technique to treat an 8-year-old boy with grade IV blunt hepatic injury and multiple organ damage. This is the first report of the use of the ABTHERA Open Abdomen Negative Pressure Therapy System (KCI, now part of 3 M Company, San Antonio, TX, USA) for DC surgery to rescue a patient without neurological sequelae.

Case presentation
An 8-year-old boy was brought to the emergency department of our hospital after being run over by a motor vehicle. He had grade IV blunt hepatic injury, thyroid injury, and bilateral hemopneumothorax. Although he was hemodynamically stable, the patient’s altered level of consciousness, the presence of a sign of peritoneal irritation, and suspicion of intestinal injury led us to perform exploratory laparotomy. As part of a DC strategy, we performed gauze packing to control hemorrhage from the liver and covered the abdomen with an ABTHERA Open Abdomen Negative Pressure Therapy System to improve the patient’s general condition. Eighteen days after admission, the patient was diagnosed with a biliary fistula, which improved with percutaneous and external drainage. He had no neurological sequelae and was discharged 102 days after injury.

Conclusion
The DC strategy was effective in children with severe blunt hepatic injury. We opted to perform DC surgery because children have less hemodynamic reserve than adults, and we believe that using this strategy before the appearance of trauma triad of death could save lives and improve outcomes. During conservative management, it is important to adopt a multistage, flexible approach to achieve a good outcome.
24-Hour Physical Behavior Balance for Better Health for All: “The Sweet-Spot Hypothesis”
Authors: Holtermann Andreas , Rasmussen Charlotte Lund , Hallman David M. , Ding Ding , Dumuid Dorothea , Gupta Nidhi 
Published: December 2021

Abstract“Sit less–move more” has been the univocal advice to adults for better health. Predominantly, this advice is based on research of physical behaviors during leisure-time. A recent study among > 100,000 adults indicates a u-shaped association between leisure-time physical activity and risk for cardiovascular disease and mortality among adults in physically active occupations. This may be explained by the considerable difference in 24-h physical behaviors between adults in sedentary and physically active occupations. Thus, the advice “sit less–move more” might not be the best for health among adults in physically active occupations. To provide a scientific approach and encourage research on 24-h physical behaviors and health for those in physically active occupations, we propose the “Sweet-Spot Hypothesis.” The hypothesis postulates that the “Sweet-Spot” of 24-h physical behaviors for better health differs between adults, depending on their occupation. Specifically, the hypothesis claims that the advice “sit less–move more” does not bring adults in physically active occupations toward their “Sweet-Spot” of 24-h physical behaviors for better health. The purpose of our paper is to encourage researchers to test this proposed hypothesis by describing its origin, its theoretical underpinning, approaches to test it, and practical implications. To promote health for all, and decrease social health inequalities, we see a great need for empirically testing the “Sweet-Spot Hypothesis.” We propose the “Sweet-Spot Hypothesis” to encourage discussion, debates, and empirical research to expand our collective knowledge about the healthy “24-h physical behavior balance” for all.