bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Orlistat on Live Birth Rate in Overweight or Obese Women Undergoing IVF-ET: A Randomized Clinical Trial
Authors: Wang Ze , Zhao Junli , Ma Xiang , Sun Yun , Hao Guimin , Yang Aijun , Ren Wenchao , Jin Lei , Lu Qun , Wu Gengxiang , Ling Xiufeng , Hao Cuifang , Zhang Bo , Liu Xinyu , Yang Dongzi , Zhu Yimin , Li Jing , Bao Hongchu , Wang Ancong , Liu Jianqiao , Chen Zi-Jiang , Tan Jichun , Shi Yuhua 
Published: May 2021

Abstract

Context
Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate.

Objective
This work aimed to determine whether pharmacologic weight-loss intervention before in vitro fertilization and embryo transfer (IVF-ET) can improve live birth rate among overweight or obese women.

Methods
We conducted a randomized, double-blinded, placebo-controlled trial across 19 reproductive medical centers in China, from July 2017 to January 2019. A total of 877 infertile women scheduled for IVF who had a body mass index of 25 or greater were randomly assigned to receive orlistat (n = 439) or placebo (n = 438) treatment for 4 to 12 weeks. The main outcome measurement was the live birth rate after fresh ET.

Results
The live birth rate was not significantly different between the 2 groups (112 of 439 [25.5%] with orlistat and 112 of 438 [25.6%] with placebo; P = .984). No significant differences existed between the groups as to the rates of conception, clinical pregnancy, or pregnancy loss. A statistically significant increase in singleton birth weight was observed after orlistat treatment (3487.50 g vs 3285.17 g in the placebo group; P = .039). The mean change in body weight during the intervention was −2.49 kg in the orlistat group, as compared to −1.22 kg in the placebo group, with a significant difference (P = .005).

Conclusion
Orlistat treatment, prior to IVF-ET, did not improve the live birth rate among overweight or obese women, although it was beneficial for weight reduction.
Tamoxifen Treatment in the Neonatal Period Affects Glucose Homeostasis in Adult Mice in a Sex-Dependent Manner
Authors: Estrada-Meza Judith , Videlo Jasmine , Bron Clara , Saint-Béat Cécile , Silva Marine , Duboeuf François , Peyruchaud Olivier , Rajas Fabienne , Mithieux Gilles , Gautier-Stein Amandine 
Published: May 2021

Abstract
Tamoxifen is a selective estrogen receptor modulator used to activate the CREERT2 recombinase, allowing tissue-specific and temporal control of the somatic mutagenesis to generate transgenic mice. Studies integrating development and metabolism require a genetic modification induced by a neonatal tamoxifen administration. Here, we investigate the effects of a neonatal tamoxifen administration on energy homeostasis in adult male and female C57BL/6J mice. C57BL/6J male and female mouse pups received a single injection of tamoxifen 1 day after birth (NTT) and were fed a high-fat/high-sucrose diet at 6 weeks of age. We measured weight, body composition, glucose and insulin tolerance, basal metabolism, and tibia length and weight in adult mice. The neonatal tamoxifen administration exerted long-term, sex-dependent effects on energy homeostasis. NTT female mice became overweight and developed impaired glucose control in comparison to vehicle-treated littermates. NTT females exhibited 60% increased fat mass, increased food intake, decreased physical activity and energy expenditure, impaired glucose and insulin tolerance, and fasting hyperglycemia and hyperinsulinemia. In contrast, NTT male mice exhibited a modest amelioration of glucose and insulin tolerance and long-term decreased lean mass linked to decreased bone weight. These results suggest that the neonatal tamoxifen administration exerted a marked and sex-dependent influence on adult energy homeostasis and bone weight and must therefore be used with caution for the development of transgenic mouse models regarding studies on energy homeostasis and bone biology.
Pregnancy-specific Reference Intervals for BNP and NT-pro BNP—Changes in Natriuretic Peptides Related to Pregnancy
Authors: Dockree Samuel , Brook Jennifer , Shine Brian , James Tim , Vatish Manu 
Published: May 2021

Abstract

Context
Cardiac disease is the leading cause of maternal mortality in the UK, so accurate cardiovascular diagnoses in pregnancy are essential. BNP (B-type natriuretic peptide) and NT-pro BNP (N-terminal-pro BNP) are useful clinical tools for investigating suspected peripartum cardiomyopathy but, as the pregnancy-specific reference intervals are undefined, it is uncertain how they should be interpreted in pregnant women.

Objectives
To define trimester-specific 95% reference intervals for BNP and NT-pro BNP in pregnancy.

Methods
Longitudinal study of 260 healthy pregnant women, with sampling in each trimester.

Results
The upper reference limit for NT-pro BNP was 200 pg/mL in the first and second trimesters, and 150 pg/mL in the third. Levels were significantly reduced in overweight women in the third trimester (P = .0001), which supports the partitioning of reference intervals by body mass index (BMI). The upper limit for BNP was 50 pg/mL, with no detectable trimester-related differences. Although other biomarkers (hemoglobin and platelets) fell throughout pregnancy, both natriuretic peptides were initially elevated before falling by the third trimester, suggesting that the observed changes in natriuretic peptides are driven by dynamic interplay between cardiac strain and progressive hemodilution. NT-pro BNP in the first trimester was inversely associated with neonatal birthweight at term (P = .011).

Conclusion
Cardiac biomarkers have an important role for investigating suspected disease in high-risk pregnant women, but a robust assessment of the levels expected in healthy pregnant women is an essential prerequisite to their application in clinical practice. This study has defined trimester- and BMI-specific reference intervals for NT-pro BNP and BNP, which may improve how women with suspected cardiovascular disease are investigated in pregnancy.
Virtual screening of curcumin analogues as DYRK2 inhibitor: Pharmacophore analysis, molecular docking and dynamics, and ADME prediction
Authors: Aman La Ode , Kartasasmita Rahmana Emran , Tjahjono Daryono Hadi 
Published: May 2021

Background: Curcumin reduces the proliferation of cancer cells through inhibition of the DYRK2 enzyme, which is a positive regulator of the 26S proteasome. Methods: In the present work, curcumin analogues have been screened from the MolPort database using a pharmacophore model that comprised a ligand-based approach. The result of the screening was then evaluated by molecular docking and molecular dynamics based on binding the free energy of the interaction between each compound with the binding pocket of DYRK2. The hit compounds were then confirmed by absorption, distribution, metabolism, and excretion (ADME) prediction. Results: Screening of 7.4 million molecules from the MolPort database afforded six selected hit compounds. By considering the ADME prediction, three prospective curcumin analogues have been selected. These are: 2‐[2‐(1‐methylpyrazol‐4‐yl)ethyl]‐1H,5H,6H,7H,8H‐imidazo[4,5‐c]azepin‐4‐one (Molport-035-369-361), methyl 4‐(3‐hydroxy‐1,2‐oxazol‐5‐yl)piperidine‐1‐carboxylate (Molport-000-004-273) and (1S)‐1‐[5‐(furan‐3‐carbonyl)‐4H,6H,7H‐pyrazolo[1,5‐a]pyrazin‐2‐yl]ethanol (MolPort-035-585-822). Conclusion: Pharmacophore modelling, combined with molecular docking and molecular dynamics simulation, as well as ADME prediction were successfully applied to screen curcumin analogues from the MolPort database as DYRK2 inhibitors. All selected compounds that have better predicted pharmacokinetic properties than that of curcumin are considered for further study.
Design and experimental evaluation of enhanced diffraction efficiency of lanthanum-based material coated laminar-type gratings in the boron K-emission region
Authors: Hatano Tadashi , Koike Masato , Terauchi Masami , Pirozhkov Alexander S. , Hayashi Nobukazu , Sasai Hiroyuki , Nagano Tetsuya 
Published: May 2021

Numerical and experimental studies have been performed to evaluate the enhancement of diffraction efficiency of diffraction gratings around B

K

-emission by overcoating lanthanum series layers on conventional metal-coated laminar-type gratings. We propose an optical design method based on the concept of spectral flux given by collection efficiency and diffraction efficiency. A diffraction grating with a small angle of incidence provides an advantage to soft x-ray spectrographs because it collects the emission at a larger solid angle compared to that of conventional grazing incidence diffraction gratings. Numerical calculations indicated that La and

L
a

F

3

were promising as overcoating materials on a laminar-type Ni-coated diffraction grating, and we performed an experimental study using

L
a

F

3

and La/C overcoatings, considering their producibility and durability. The diffraction efficiencies were measured using a reflectometer at a synchrotron facility. The diffraction efficiencies observed at 183.4 eV were 29.4% and 34.3% at angles of incidence of 85.1° and 84.9° for

N
i

/

L
a

F

3

and Ni/La/C gratings, respectively.
A new approach to quantify angles and time of changes-of-direction during soccer matches
Authors: Kai Tomohiro , Hirai Shin , Anbe Yuhei , Takai Yohei 
Published: May 2021

Background and aims
Soccer players frequently perform change-of-directions (CODs) at various speeds during matches. However, tracking systems have shown limitations to measure these efforts. Therefore, the aim of the present study was to propose a new approach to measure CODs using a local positioning system (LPS), and clarify position-related difference in profile of CODs by using the approach.

Methods
The x- and y-coordinate data for each soccer player were measured with a local positioning system. Speed, acceleration, jerk, and direction of speed were derived from the coordinate data. Based on accelerations of above 2 m/s2, the onsets and ends of CODs derived from jerk were identified (COD duration). Changes of direction of speed (θCOD) were determined for the corresponding period. Six collegiate male soccer players performed CODs according to 13 set angles (0–180°; every 15°) so that differences between θCOD and set angle could be determined (Exp. 1). Relative frequency distributions of θCOD and number of CODs were determined in 79 collegiate and amateur male soccer players during 9 soccer matches (Exp. 2).

Results
In Exp. 1, θCOD was positively related to set angle (r = 0.99). Each θCOD was smaller than the corresponding set angle, and the difference became greater with increasing COD angle. In Exp. 2, The number of CODs in a match was 183 ± 39 across all positions. There were no significant position-related differences in the number of CODs. The duration of a COD was 0.89 ± 0.49 s across all positions. The relative frequency distribution of θCOD revealed that the number of CODs at 0–15° and 105–135° tended to be higher than those at other angles during soccer matches. Further, θCOD was affected by the speed at the onset of COD during soccer matches (Exp. 2).

Conclusions
The current findings demonstrate that θCOD derived from direction of speed and jerk may be a new indicator for evaluating COD during soccer matches.
Management and outcomes of patients with chronic obstructive lung disease and lung cancer in a public healthcare system
Authors: Goffin John R. , Corriveau Sophie , Tang Grace H. , Pond Gregory R. 
Published: May 2021

Hypothesis
There is limited data on the care and outcomes of individuals with both chronic obstructive pulmonary disease (COPD) and lung cancer, particularly in advanced disease. We hypothesized such patients would receive less cancer treatment and have worse outcomes.

Methods
We analyzed administrative data from the province of Ontario including demographics, hospitalization records, physician billings, cancer diagnosis, and treatments. COPD was defined using the ICES-derived COPD cohort (1996–2014) with data from 2002 to 2014. Descriptive statistics and multivariable analyses were undertaken.

Results
Of 105 304 individuals with lung cancer, 43 375 (41%) had stage data and 36 738 (34.9%) had COPD. Those with COPD were likely to be younger, have a Charlson score ≤ 1, have lower income, to live rurally, and to have stage I/II lung cancer (29.8 vs 26.5%; all p<0.001). For the COPD population with stage I/II cancer, surgery and adjuvant chemotherapy were less likely (56.8 vs. 65.9% and 15.4 vs. 17.1%, respectively), while radiation was more likely (26.0 vs. 21.8%) (p all < 0.001). In the stage III/IV population, individuals with COPD received less chemotherapy (55.9 vs 64.4%) or radiation (42.5 vs 47.5%; all p<0.001). Inhaler and oxygen use was higher those with COPD, as were hospitalizations for respiratory infections and COPD exacerbations. On multivariable analysis, overall survival was worse among those with COPD (HR 1.20, 95% CI 1.19–1.22).

Conclusions
A co-diagnosis of COPD and lung cancer is associated with less curative treatment in early stage disease, less palliative treatment in late stage disease, and poorer outcomes.
Assessing Targeted Containment Policies to Fight COVID-19
Authors: Checo Ariadne , Grigoli Francesco , Mota Jose M. 
Published: May 2021

Abstract
The large economic costs of full-blown lockdowns in response to COVID-19 outbreaks, coupled with heterogeneous mortality rates across age groups, led to question non-discriminatory containment measures. In this paper we provide an assessment of the targeted approach to containment. We propose a SIR-macro model that allows for heterogeneous agents in terms of mortality rates and contact rates, and in which the government optimally bans people from working. We find that under a targeted policy, the optimal containment reaches a larger portion of the population than under a blanket policy and is held in place for longer. Compared to a blanket policy, a targeted approach results in a smaller death count. Yet, it is not a panacea: the recession is larger under such approach as the containment policy applies to a larger fraction of people, remains in place for longer, and herd immunity is achieved later. Moreover, we find that increased interactions between low- and high-risk individuals effectively reduce the benefits of a targeted approach to containment.
Case study: Vocational student’s knowledge and awareness level toward renewable energy in Indonesia
Authors: Muslim Riyadi , Saputro Herman , Thamrin AG 
Published: May 2021

Abstract
The facts of increasing use and decreasing fossil energy have made many people think of using renewable energy. Mindset change and dependence on fossil energy can be rectified through education. Renewable energy education is needed to increase student’s knowledge and awareness. There are only 12 vocational high schools (VHSs) based on renewable energy in Indonesia. This number is not in line with the government’s efforts to revitalize vocational schools toward a sustainable energy state in the future. This article features the knowledge and awareness of vocational students on renewable energy in Indonesia. Data were obtained from 1,250 respondents from 88 VHSs and 27 provinces in Indonesia. Knowledge and awareness level of school students in Indonesia VHSs is discussed in depth based on variables such as gender, parents, island, public school and private school, and areas of expertise at VHS. Respondents filled out questionnaires through a web survey. A descriptive analysis was performed based on the data. National coverage of data related to the vocational student’s knowledge and awareness of renewable energy is the novelty of this article. The results show that VHS students already have a knowledge level in the “good” category for renewable energy and have an awareness level in the “fair” category. Detailed analysis on the reasons is performed as well as solution is offered in this article.
Chaos and bifurcations in a discretized fractional model of quasi-periodic plasma perturbations
Authors: Matouk Ahmed Ezzat 
Published: May 2021

Abstract
The nonlinear dynamics of a discretized form of quasi-periodic plasma perturbations model (Q-PPP) with nonlocal fractional differential operator possessing singular kernel are investigated. For example, the conditions for the stability and occurrence of Neimark–Sacker (NS) and flip bifurcations in the proposed discretized equations are provided. Moreover, analysis of nonlinearities such as the existence of chaos in this map is proved numerically via bifurcation diagrams, Lyapunov exponents and analytically via Marotto’s Theorem. Also, some simulation results are utilized to confirm the theoretical results and to show that the obtained map exhibits double routes to chaos: one is via flip bifurcation and the other is via NS bifurcation. Furthermore, more complex dynamical phenomena such as existence of closed invariant curves, homoclinic orbits, homoclinic connections, period 3 and period 4 attractors are shown. This kind of research is useful for physicists who work with tokamak models.
Comparative HPTLC fingerprinting profile and GC-MS analysis of raw and purified Guggulu (Commiphora wightii. Arn. Bhand) by Ayurvedic purification method
Authors: Menon Indu M. , Eapen Jollykutty , M. S. Deepa 
Published: May 2021

Abstract

Background

Guggulu is an oleo gum resin obtained from the plant Commiphora wightii (Arn.) Bhand., used in Ayurved
ic medicines for various ailments like anti-inflammatory conditions, hyperlipidemia, thyroid disorders etc. Guggulsterones E & Z are responsible for these broad ranges of pharmacological actions. It is recommended to do Shodhana (purification) before incorporating it into medicinal formulations. Sahasrayoga, an Ayurvedic text, emphasizes the purification of Guggulu in a particular media, which is a long run practice in Kerala.

Objectives
To compare the physicochemical and phytochemical parameters, quantitative estimation of Guggulsterone E & Z using high performance thin layer chromatography (HPTLC) and qualitative gas chromatography-mass spectrometry (GC-MS) analysis of Guggulu before and after purification.

Methods

Shodhana of Guggulu was performed in Water boiled with crushed fresh leaves of Neem (Azadirachta indica) and fresh rhizome of turmeric (Curcuma longa) using a special equipment (Dolayantra). Preliminary physicochemical and phytochemical evaluation, quantification of Guggulsterones E & Z using HPTLC and GC-MS analysis of raw and purified Guggulu were performed.

Results
Phytochemical evaluation of metabolites revealed marked variations. The mean concentrations of Guggulsterone E & Z showed significant differences before and after purification (p<0.01). On GC-MS analysis, it was found that few new compounds were added in the purified Guggulu.

Conclusions
Therapeutic efficacy of Guggulu might have enhanced after traditional purification.
Intellectualization of the urban and rural bus: The arrival time prediction method
Authors: Wang Yunna 
Published: May 2021

Abstract
To improve the intelligence of urban and rural buses, it is necessary to realize the accurate prediction of bus arrival time. This paper first introduced urban and rural buses. Then, the arrival time prediction was divided into two parts: road travel time and stop time, and they were predicted by the support vector regression method and k-nearest neighbor (KNN) method. A section of a bus route in Pingdingshan city of Henan province was taken as an example for analysis. The results showed that the method designed in this study had better accuracy, and the result was closer to the actual value, with a maximum error of 84 s, a minimum error of 10 s, an average error of 42.5 s, and an average relative error of 5.74%, which could meet the needs of passengers. The results verify the reliability of the designed method in predicting the arrival time of urban and rural buses, which can be popularized and applied in practice.
The value of miR-510 in the prognosis and development of colon cancer
Authors: Hang Junjie , Wei Feifei , Yan Zhiying , Zhang Xianming , Xu Kequn , Zhu Yingwei 
Published: May 2021

Abstract

Purpose
Colon cancer is one of the malignant tumors that threatens human health. miR-510 was demonstrated to play roles in the progression of various cancers; its dysregulation was speculated to be associated with the development of colon cancer.

Methods
One hundred and thirteen colon cancer patients participated in this research. With the help of RT-qPCR, the expression of miR-510 in collected tissues and cultured cells was analyzed. The association between miR-510 expression level and clinical features and prognosis of patients was evaluated. Moreover, the effects of miR-510 on cell proliferation, migration, and invasion of colon cancer were assessed by CCK8 and Transwell assay.

Results
miR-510 significantly upregulated in colon cancer tissues and cell lines relative to the adjacent normal tissues and colonic cells. The expression of miR-510 was significantly associated with the TNM stage and poor prognosis of patients, indicating miR-510 was involved in the disease progression and clinical prognosis of colon cancer. Additionally, the upregulation of miR-510 significantly promoted cell proliferation, migration, and invasion of colon cancer, while its knockdown significantly inhibited these cellular processes. SRCIN 1 was the direct target of miR-510 during its promoted effect on the development of colon cancer.

Conclusion
The upregulation of miR-510 acts as an independent prognostic indicator and a tumor promoter by targeting SRCIN 1 in colon cancer, which provides novel therapeutic strategies for colon cancer.
Functional implications of PABPC1 in the development of ovarian cancer
Authors: Feng Cong , Han Yan-Hua , Qi Na , Li Jia , Sheng Qing-Hua , Liu Yu , Yang Li-Li 
Published: May 2021

Abstract
This research aimed to probe the expression characteristics of poly(A)-binding protein cytoplasmic 1 (PABPC1) and its role on the phenotype of ovarian cancer (OC) cells and to further investigate the possible underlying mechanism. The expression of PABPC1 was analyzed according to the data from gene expression omnibus, The Cancer Genome Atlas (TCGA) and Oncomine databases and the RNA sequencing data set from TCGA were downloaded for evaluating the prognostic values. We revealed that compared with the healthy samples, PABPC1 was upregulated in OC samples. High expression of PABPC1 had a connection with a shorter survival for patients with OC. Loss and gain of function assays revealed that silencing PABPC1 significantly suppressed the viability, invasion and migration of SK-OV-3 cells, while PABPC1 overexpression in A2780 cells showed the reverse outcomes. Moreover, Western blot demonstrated that silencing PABPC1 notably inactivated the epithelial–mesenchymal transition (EMT) process, while upregulation of PABPC1 promoted the mitigation of epithelial phenotype and the acquisition of mesenchymal phenotype. Taken together, PABPC1 was upregulated in OC cells and served as a carcinogene to promote the OC cell growth and invasion partly by modulating the EMT process, which implied that PABPC1 might be considered as a useful biomarker for OC therapeutics.