bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with mild cognitive impairment diagnosed at dementia clinic display decreased maximum occlusal force: a cross-sectional study
Authors: Suzuki Hiroyuki , Furuya Junichi , Hidaka Rena , Miyajima Saki , Matsubara Chiaki , Ohwada Gaku , Asada Takashi , Akazawa Chihiro , Sato Yuji , Tohara Haruka , Minakuchi Shunsuke 
Published: December 2021

Abstract
Background
Previous research indicates that patients with mild cognitive impairment (MCI) are more likely to have poor oral health and impairments in oral functions, which may be due to few remaining teeth and impaired tongue and lip motor function. However, the oral health of those patients following comprehensive cognitive assessment by a dementia specialist has not been sufficiently investigated. Therefore, this study aimed to clarify the oral function of patients with MCI and the association between oral health and lower cognitive function.

Methods
This cross-sectional study included 96 participants (men: 35; women: 61; mean age: 73.3 ± 8.5 years) who visited a dementia clinic between December 2017 and January 2020. Participants’ cognitive function was assessed by a dementia specialist using neuropsychological and hematological tests and neuroimaging immediately after enrollment. The participants were divided into the healthy and MCI groups according to comprehensive cognitive assessment. Participants’ age, sex, body mass index, primary disease, education level, drinking habits, smoking habits, living environment, employment status, and exercise habits were evaluated. Moreover, oral outcomes, including the number of existing teeth, number of functional teeth (natural and prosthetic teeth which were occluded with antagonists), denture use, oral dryness, tongue and lip motor function, tongue pressure, occlusal force, masticatory ability, and swallowing ability were recorded. The Mann–Whitney U test, χ2, and Fisher’s exact tests were used for between-group comparisons. Furthermore, logistic regression analysis using MCI diagnosis as the target variable was performed.

Results
A comprehensive evaluation of the cognitive function of the study participants by the dementia specialist revealed that 48 participants (mean age: 69.8 ± 8.8 years) were healthy and 48 (mean age: 76.9 ± 6.7 years) had MCI. MCI participants were significantly older (p < 0.001) and had significantly fewer existing teeth (p = 0.031) and lower maximum occlusal force (p = 0.019) than healthy participants. Age (odds ratio: 1.126, p = 0.002) and maximum occlusal force (odds ratio: 0.978, p = 0.048) were significantly associated with lower cognitive function.

Conclusions
Patients with MCI had poorer oral health than healthy individuals. Decreased maximum occlusal force was independently associated with lower cognitive function, even when adjusted for age and sex.
Effect of educational intervention based on health belief model on accident prevention behaviours in mothers of children under 5-years
Authors: Moridi Elnaz , Fazelniya Zahra , Yari Asiyeh , Gholami Tahereh , Hasirini Pooyan Afzali , Khani Jeihooni Ali 
Published: December 2021

Abstract
Background
As the public health problems, accidents are the most important causes of child mortality. The present study aimed to determine the effect of educational intervention based on health belief model on accident prevention behaviors in mothers of children under 5-years of age.

Methods
This quasi-experimental study was conducted on 200 mothers in Fasa city who were purposefully selected and randomly divided into two groups of intervention and control. Data collection tools were demographic characteristics and health belief model questionnaire. Questionnaires were completed twice before and 3 months after the intervention. After the pre-test, the educational intervention was performed through 6 sessions of 30–35 min in a WhatsApp group. Data were analyzed using SPSS 22 through Chi-square test, independent t-test and paired t-test (p = 0.05).

Results
The mean age of mothers in the experimental and control groups was 30.14 ± 4.35 and 31.08 ± 4.31 years. Mean score of awareness, perceived sensitivity, perceived severity, perceived benefits, perceived self-efficacy, cues to action, and accident prevention behaviors significantly increased 3 months after the intervention.

Conclusion
This study showed the effectiveness of educational intervention based on health belief model on accident prevention behaviors in mothers of children under 5-years of age.
Cost estimates of COVID-19 clinical management in Myanmar
Authors: Thant Phyu Win , Htet Khin Thu , Win Wit Ye , Htwe Ye Min , Htoo Thant Sin 
Published: December 2021

Abstract
Objective
This study aims to estimate the cost of clinical management of COVID-19 infected patients based on their severity by exploring the resources used in health care provision in Myanmar.

Methods
A multicenter retrospective cost analysis of COVID-19 patients was performed using the micro-costing approach from the perspective of the health system. It covered two cost components, namely direct and indirect cost of treating a patient. Input data and their quantities were obtained from COVID-19 Standard Treatment Guidelines of Ministry of Health and Sports, and administrative and financial records of resource utilization of three designated health facilities in Yangon Region. Valuation of these resources was based on the price list from the Procurement Section of the Ministry.

Results
This study estimated the unit cost of clinical management of COVID-19 infected patients with no symptom to be 953,552 MMK(717 USD), with mild-moderate symptoms to be 1,155,222 MMK(869 USD) and with severe-critically ill conditions to be 5,705,052 MMK(4290 USD). Average cost for a patient par day was 86,687 MMK(65 USD) for asymptomatic patients, 105,020 MMK(79 USD) for mild-moderate patients and 283,252 MMK(214 USD) for severe-critically ill patients. Since the first case detected till December 31, 2020, COVID-19 clinical management cost was accounted for 139 Billion MMK (104 Million USD) for total 124,630 confirmed cases.

Conclusions
COVID-19 pandemic has caused health systems to incur the significant health care expenses. Timely implementation of the sustainable, affordable and efficient policy for COVID-19 responses is of utmost important for every nation especially in the face of a pandemic. This study provides the fundamental inputs for strategic planning, for future economic evaluations of different policy interventions, and policy recommendations for health systems to remain resilient during and after the COVID-19 pandemic in Myanmar.
All we need to know about internal thoracic artery harvesting and preparation for myocardial revascularization: a systematic review
Authors: Masroor Matiullah , Zhou Kang , Chen Chunyang , Fu Xianming , Zhao Yuan 
Published: December 2021

AbstractInternal thoracic arteries (ITAs) are the gold standard conduits for coronary revascularization because of their long-term patency and anti-atherosclerotic properties. Harvesting and preparation of ITAs for revascularization is a technically demanding procedure with multiple challenges. Over the last few decades, various methods and techniques for ITAs harvesting have been introduced by different surgeons and applied in clinical practice with different results. Harvesting of ITAs in pedicled or skeletonized fashion, with electrocautery or harmonic scalpel, with open or intact pleura, with clipping the end or keeping it perfused; papaverine delivery with intraluminal injection, perivascular injection, injecting into endothoracic fascia, and papaverine topical spray are the different techniques introduced by the number of researchers. At the same time, access to the ITAs for harvesting has also been studied. Access and harvesting through median sternotomy, mini anterolateral thoracotomy, thoracoscopic, and robotic-assisted harvesting of ITAs are the different techniques used in clinical practice. However, the single standard method for harvesting and preparation of ITAs has yet to be determined. In this review article, we aimed to discuss and analyze all these techniques of harvesting and preparing ITAs with the help of literature to find the best way for ITAs harvesting and preparation for myocardial revascularization.
Changes in chromatin accessibility landscape and histone H3 core acetylation during valproic acid-induced differentiation of embryonic stem cells
Authors: Baumann Claudia , Zhang Xiangyu , Zhu Ling , Fan Yuhong , De La Fuente Rabindranath 
Published: December 2021

AbstractDirected differentiation of mouse embryonic stem cells (mESCs) or induced pluripotent stem cells (iPSCs) provides powerful models to dissect the molecular mechanisms leading to the formation of specific cell lineages. Treatment with histone deacetylase inhibitors can significantly enhance the efficiency of directed differentiation. However, the mechanisms are not well understood. Here, we use CUT&RUN in combination with ATAC-seq to determine changes in both histone modifications and genome-wide chromatin accessibility following valproic acid (VPA) exposure. VPA induced a significant increase in global histone H3 acetylation (H3K56ac), a core histone modification affecting nucleosome stability, as well as enrichment at loci associated with cytoskeletal organization and cellular morphogenesis. In addition, VPA altered the levels of linker histone H1 subtypes and the total histone H1/nucleosome ratio indicative of initial differentiation events. Notably, ATAC-seq analysis revealed changes in chromatin accessibility of genes involved in regulation of CDK serine/threonine kinase activity and DNA duplex unwinding. Importantly, changes in chromatin accessibility were evident at several key genomic loci, such as the pluripotency factor Lefty, cardiac muscle troponin Tnnt2, and the homeodomain factor Hopx, which play critical roles in cardiomyocyte differentiation. Massive parallel transcription factor (TF) footprinting also indicates an increased occupancy of TFs involved in differentiation toward mesoderm and endoderm lineages and a loss of footprints of POU5F1/SOX2 pluripotency factors following VPA treatment. Our results provide the first genome-wide analysis of the chromatin landscape following VPA-induced differentiation in mESCs and provide new mechanistic insight into the intricate molecular processes that govern departure from pluripotency and early lineage commitment.
Promoting outdoor recreation among older adults in Sweden – a theoretical and empirical foundation for the development of an intervention
Authors: Zingmark Magnus , Ankre Rosemarie , Wall-Reinius Sandra 
Published: December 2021

Abstract
Background
Disengagement from outdoor recreation may diminish the positive benefits on health and well-being in old age. The purpose of this study is to present a contextual, theoretical, and empirical rationale for an intervention, aiming to promote continued engagement in outdoor recreation for older adults in a Swedish context.

Methods
The paper includes a contextualization of outdoor recreation in Sweden, a presentation of evidence on health benefits related to engagement in outdoor recreation, together with theoretical frameworks that may guide future intervention designs. To add empirical knowledge, a mixed methods approach was applied, including an empirical data collection based on a quantitative survey (n = 266) and individual semi-structured interviews with older adults (n = 12). Survey data were presented with descriptive statistics. Associations between disengagement from previously performed activities and age and gender was analyzed with Chi2 tests. Transcripts and handwritten notes from the interviews were analyzed qualitatively to identify key themes, as well as patterns and disparities among respondents.

Results
Outdoor recreation was rated as important/very important by 90% of respondents of the survey. The interviews highlighted that engagement in outdoor recreation aided respondents to keep fit but had also relevance in terms of identity, experiences, and daily routines. Outdoor recreation close to the place of residence was most common and walking was the most frequently reported activity. While 80% considered their health to be good/very good, disability and long-term diseases were common and during the previous year, more than half of all respondents had disengaged from activities previously performed. Reasons for disengagement were mainly related to health decline or that activities were too demanding but also due to social loss. The interviews indicated that continued engagement was important but challenging, and that disengagement could be considered as a loss or accepted due to changing circumstances.

Conclusions
In the design of an intervention aiming to promote engagement in outdoor recreation for older adults, the following features are proposed to be considered: person-centeredness, promoting functioning, addressing self-ageism, providing environmental support, promoting subjective mobility needs and adaptation to find new ways to engage in outdoor recreation.
Brainatomy—Demystifying the Temporal Bone, Rule of 3-2-1
Authors: Er Kadir , Patsalis Dimitrios , Katsigiannis Sotirios , Schmieder Kirsten , Baskaya Mustafa K. , Gierthmuehlen Mortimer 
Published: December 2021

BACKGROUND:
The temporal bone is difficult to comprehend in three-dimensional (3D) space. We provide a novel 3D mental model of the temporal bone which helps clinicians and surgeons dealing with it in teaching, diagnosing, conservative managements, and preoperative and intraoperative orientation. This study is part of the scientific project Brainatomy.

OBJECTIVE:
To analyze and simplify the temporal bone anatomy to enhance its comprehension and long-term retention.

METHODS:
The study was conducted at the Neurosurgical Department of the University Hospital of Bochum, Germany. We retrospectively analyzed data sets of 221 adult patients who underwent computed tomography (CT) of the skull (n = 167) and magnetic resonance imaging (MRI) of the brain (n = 54). A total of 142 patients with their respective imaging scans remained in our pool of interest after excluding 79 scans. The raw digital imaging and communications in medicine scans were transformed into 3D objects. Spatial analyses were then conducted, and all collected data were used to create our own 3D model of the temporal bone.

RESULTS:
We define the temporal bone as a prism-shaped model and divide it into 6 compartments: apex, neurovascular, mastoid, blank, tympanic, and temporomandibular compartments. The division into compartments has been achieved with the “Rule of 3-2-1.” Finally, the 3D model has been used to record a video (Video), using a novel and “easy-to-follow” didactic approach.

CONCLUSION:
This simplified 3D model along with the corresponding video (Video) potentially enhances the efficiency of studying temporal none anatomy with a novel “easy-to-follow” approach.
Predictors of sexual function among men after myocardial infarction: a pilot study
Authors: Smith Asa B , Barton Debra L , Jackson Elizabeth A , Wittmann Daniela , Smith Jacqui , Davis Matthew 
Published: December 2021

Background/Aims Sexual dysfunction often persists among men who have had a myocardial infarction. While some cross-sectional and longitudinal research has been conducted, there are still no known modifiable targets for intervention. This pilot study aimed to model hypothesised predictive factors of higher sexual function in a cohort of men post myocardial infarction. Methods Using a longitudinal study design, data on sexual function, sexual fear, anxiety and depressive symptoms, and use of coping strategies were collected using the Male Sexual Function Index, Multidimensional Sexuality Questionnaire, Patient-Reported Outcomes Measurement Information System and Coping Strategy Indicator respectively. Spearman correlations were estimated to examine associations between factors at 2 weeks and 3 months following myocardial infarction. Linear regression models were conducted for sexual function while controlling for age. Results The data for 14 men were analysed. Sexual fear and use of problem-solving and support-seeking coping strategies were moderately correlated with sexual function at 3 months post myocardial infarction. Increased use of problem-solving and support-seeking coping strategies was associated with increased sexual function at 3 months. Conclusions Use of coping strategies may predict increased sexual function 3 months post myocardial infarction. However, additional studies are needed to further examine these hypothesised relationships with a larger and more diverse sample.
Multidisciplinary Approaches to Art and Creativity: Fostering Artistic Exploration in Formal and Informal Settings, Karen Knutson, Takeshi Okada and Kevin Crowley (Eds) (2020)
Authors: Stokrocki Mary 
Published: December 2021

Review of: Multidisciplinary Approaches to Art and Creativity: Fostering Artistic Exploration in Formal and Informal Settings, Karen Knutson, Takeshi Okada and Kevin Crowley (Eds) (2020)
New York: Routledge, 296 pp.,
ISBN 978-0-81536-188-6, e-book, £33.29
Produksi Xilitol Menggunakan Hidrolisat Tongkol Jagung (Zea mays) Oleh Meyerozyma caribbica InaCC Y67
Authors: Faradila Ayu Near Putri , Nurhayati N , Thontowi Ahmad , Kusdiyantini Endang , Kanti Atit , Hermiati Euis 
Published: December 2021

Xylitol (C5H12O5) is a non-carcinogenic polyalcoholic sugar. Xylitol is beneficial for diabetics because it can be metabolized without insulin. Corn cobs contain 30% xylose which can be fermented into xylitol by microorganisms. Xylitol can be produced by fermentation of xylose and few microorganisms. Meyerozyma caribbica is a yeast that has been proven to produce xylitol and inhibitor’s resistant. The aim of this research is to test the xylitol productivity by Meyerozyma caribbica InaCC Y67 using corn cobs hydrolyzate and the effect of the volume of fermentation media on xylitol productivity by Meyerozyma caribbica InaCC Y67. The method was carried out by culturing Meyerozyma caribbica InaCC Y67 as a starter on YPD media. Fermentation using 100 mL Erlenmeyer with the variation of fermentation volume is 10 ml and 75 ml, agitation 175 rpm and 30 oC. Parameters were measured based on the dry weight of cells, xylose and xylitol. Data were analyzed using fermentation kinetics. The results of analysis showed that the higher xylitol production was found in the fermentation volume 75 ml with an efficiency value of 7,171%. The highest xylitol production was at the 48th hour with production value of 2.050 g/L. Results from research shows that Meyerozyma caribbica InaCC Y67 can produce xylitol with corn cobs hydrolyzate. The right volume of fermentation in the fermentation process can also increase the productivity of xylitol.
Using a Multi-Methods Approach to Investigate Disaster Preparedness of Community Libraries in the North West Province of South Africa
Authors: Chizwina Sabelo , Ngulube Patrick 
Published: December 2021

Abstract
Disasters can occur anywhere, and no organisation is immune to disasters. Community libraries in South Africa have experienced disasters over the past years, ranging from natural disasters to human-made disasters. This research aims to investigate the disaster preparedness of community libraries in the North West Province of South Africa. A multi-methods approach that involved questionnaires, interviews, and document analysis was used. The study results revealed that although community libraries have experienced disasters, they considered them as once-off events. Consequently, disaster management was not part of the collection management policy. However, disaster management should be a key component of collection development, and it should be part and parcel of a collection management policy.
Occupancy disorder in the magnetic topological insulator candidate Mn1−x
Sb2+x
Te4
Authors: Folkers Laura C. , Corredor Laura Teresa , Lukas Fabian , Sahoo Manaswini , Wolter Anja U. B. , Isaeva Anna 
Published: December 2021

Abstract
MnSb2Te4 is a candidate magnetic topological insulator exhibiting more pronounced cation intermixing than its predecessor MnBi2Te4. Investigating the cation intermixing and its possible implications on the magnetic order in MnSb2Te4 are currently hot topics in research on quantum materials for spintronics and energy-saving applications. Two single-crystal X-ray diffraction measurements of Mn1−x
Sb2+x
Te4 (x = 0.06 and x = −0.1) are presented alongside a detailed discussion of its crystal structure with a spotlight on the apparent occupancy disorder between the two cations. This disorder has been noted by other groups as well, yet never been analyzed in-depth with single-crystal X-ray diffraction. The latter is the tool of choice to receive a meaningful quantification of antisite disorder. Between the two synthesis procedures we find subtle differences in phases and/or alternation of the cation content which has implications on the magnetic order, as illustrated by bulk magnetometry. Understanding and assessing this disorder in magnetic topological insulators of the MnX2Te4 (X = Bi, Sb) type is crucial to gauge their applicability for modern spintronics. Furthermore, it opens new ways to tune the “chemical composition – physical property” relationship in these compounds, creating an alluring aspect also for fundamental science.
Time and space waveform optimization to extend the harmonic cutoff and to produce the water window single attosecond pulse
Authors: Feng Liqiang , Yuan Quan 
Published: December 2021

Abstract
Based on the three-step theory of high-order harmonic generation, the harmonic cutoff is very sensitive to the few-cycle laser waveform in both time and space regions. Therefore, in this paper, we propose the method to control the harmonic cutoff and to produce the water window attosecond pulse through the optimization of time and space waveform. It is found that, in the time region, by properly choosing the delay and phase of the few-cycle two-color pulse, not only the harmonic intensity is enhanced, but also the quantum path of the harmonic emission can be controlled. Further, with the introduction of the 3rd pulse (i.e., the infrared pulse or the unipolar pulse), the harmonic cutoff from the single harmonic emission peak can be extended, showing a water window harmonic plateau. In the space region, by using the positive spatial inhomogeneous effect, the harmonic cutoff from the basic two-color waveform can also be extended, which leads to a water window spectral continuum. Finally, by Fourier transformation of harmonics during the water window region, the ultrashort single 29 as pulses can be obtained.
Eksistensi Tenun Troso Jepara Di Antara Berdirinya Perusahaan-perusahaan Garmen
Authors: Anisah, Muh Fakhrihun Na’am Novia Nur 
Published: December 2021

Tenun Troso adalah salah satu kekhasan yang dimiliki oleh Kabupaten Jepara berupa kain yang terbuat dari benang yang ditenun dengan cara memasukkan pakan secara melintang dengan lungsi. Tujuan Penelitian ini untuk mengetahui eksistensi tenun Troso Jepara di antara berdirinya perusahaan-perusahaan garmen. Metode penelitian yaitu metode kuantitatif. Populasi penelitian ini adalahÂ pengusaha Troso, perajin tenun Troso, perajin tenun Troso yang keluar dari tenun Troso dan menjadi karyawan garmen dan warga Desa Troso yang bekerja di perusahaan garmen sekitar Desa Troso serta karyawan PT. Hwaseung Indonesia dan PT. Parkland World Indonesia. Teknik pengambilan sampel menggunakan rumus Slovin dan mendapat respondenÂ sebesar 100 responden. Analisis data menggunakan analisis deskripstif presentase menggunakan SPSS versi 20. Hasil menunjukan bahwa rata-rata dari semua indikator menunjukan nilai indeks cukup tinggi yaitu 70.5. Mempunyai nilai mean sebesar 105.12, nilai median 105, nilai mode sebesar 105, nilai variasi sebesar 3.660546, nilaiÂ skewnessÂ sebesar -0.59337, nilaiÂ kurtosisÂ sebesar 0.27886, nilaiÂ rangeÂ sebesar 19. Nilai minimum sebesar 94 dan nilai maksimum 113. Serta nilai sum sebesar 10512.