bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immobilization of Daurian Rosehip Antioxidants by Protein-Lipid Inclusion
Authors: Bazhenova Bayana , Burkhanova Anastasia , Zabalueva Yuliya , Dobretsky Roman 
Published: June 2021

Introduction. Antioxidant system is one of the main cellular mechanisms of adaptation. It is able to neutralize the destructive effect of free radicals, both external and internal. Functional products, especially of meat origin, can provide necessary antioxidant properties. Some types of plant raw materials possess a high content of polyphenol complexes with antioxidant properties. Therefore, introduction of phytonutrients into the composition of meat products can help to expand the range of foods with an antioxidant effect. Daurian rosehip is rich in biologically active substances and can increase their safety during processing. The research objective was to study the possibility of immobilization of Daurian rosehip antioxidants by protein-lipid inclusion.
Study objects and methods. The research featured fruits of Daurian rosehip, its aqueous alcoholic extract, and protein-lipid complex.
Results and discussion. The article presents experimental data on the chemical composition of Daurian rosehip. The optimal method with the best antioxidant results was a microwave phytoextraction by an aqueous alcoholic solution at a power of 800 W for 6–7 min. The antioxidants were immobilized by including the protein-lipid complex into the gel. The experiment demonstrated excellent functional and technological characteristics of the resulting system.
Conclusion. The research revealed the optimal modes of microwave extraction of biologically active substances of Daurian rosehip. The rosehip extract was included into the protein-lipid complex and immobilized antioxidants, thus increasing their efficiency.
Genomic detection of waterborne enteric viruses as water quality indicators in Al-Zarqa River, Jordan
Authors: Saadoun Ismail , Ababneh Qutaiba , Jaradat Ziad 
Published: June 2021

Abstract
Al-Zarqa River is the second main tributary to River Jordan after the Yarmouk River. The river flow has been modified by discharge of industrial wastewater and treated domestic water. Concerns about the occurrence of waterborne pathogenic viruses in the surface waters of Al-Zarqa River prompted the analysis of the surface water quality with respect to the presence of enteric viruses. Viruses were concentrated from a total of 33 different water environmental samples including raw sewage, effluent samples and river water collected from and around the river over a period of 11 months. Calculated recovery yields for these concentration methods ranged between 2 and 8%. Polymerase chain reaction (PCR), reverse transcriptase-PCR (RT-PCR), nested RT-PCR and southern blotting hybridization analysis were used for the detection of hepatitis A virus, norovirus, astrovirus and human adenovirus 40/41, with the later one being detected in 21 (64%) of the samples that also showed previous positive presence for enteroviruses. To our knowledge, this is the first molecular biology report in Jordan describing the circulation of adenoviruses, which were detected more frequently than enteroviruses in sewage and water samples, and therefore, they can be used as an index for the presence of human pathogenic viruses in water environment.
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer
Authors: Sahu Rakesh , Mishra Rakhi , Kumar Rajnish , Salahuddin  , Majee Chandana , Mazumder Avijit , Kumar Ajay 
Published: June 2021

Abstract:The incidence of cancer is increasing worldwide, affecting a vast majority of the human population, therefore, new different anticancer agents are being developed now and their safety still needs to be evaluated. Among them, pyridine based drugs are contributing a lot, as they are one of the imperative pharmacophores occurring synthetically as well as naturally in heterocyclic compounds, having a wide-range of therapeutic applications in the area of drug discovery that offers many chances for further improvement in antitumor agents via acting onto numerous receptors of extreme prominence. Many pyridine derivatives are reported to inhibit enzymes, receptors and many other targets for controlling and curing the global health issue of cancer. Nowadays in combination with other moieties, researchers are focusing on the development of pyridine-based new derivatives for cancer treatment. Therefore, this review sheds light on the recent therapeutic expansion of pyridine together with its molecular docking, structure-activity-relationship, availability in the market, a summary of recently patented and published research works that shall jointly help the scientists to produce effective drugs with the desired pharmacological activity.
Molecular Modelling Simulations and Inhibitory Effects of Naturally Derived Flavonoids Targeting Platelet-Activating Factor Receptor (PAFR)
Authors: Nordin Noraziah , Jalil Juriyati , Ghani Mohd Faiz Abd , Abdullah Adib Afandi , Othman Rozana 
Published: June 2021

Background:Platelet-activating factor (PAF) is an agonist mediator in the inflammatory process, which interacts with PAF receptor (PAFR) that eventually causes cancers, respiratory and neurodegenerative diseases. This interaction activates the mitogen-activated protein kinase (MAPK) pathway, leading to a pro-inflammatory cascade. The pathophysiological conditions due to activation of inflammatory cascade could be inhibited by PAF antagonists.Objectives:In this study, selected naturally derived flavonoids (flavone, biochanin A, and myricetin) with different functional groups were subjected to molecular modelling and experimental studies to investigate their potential as PAF antagonists.Method:Interactions of flavonoids and PAF were assessed via Autodock Vina for molecular docking and the AMBER program for molecular dynamic simulations. The experimentally antagonistic effects of the flavonoids were also conducted via PAF inhibitory assay to determine the IC50 values.Results:The findings of docking and dynamic simulations have revealed that all selected flavonoids interact with PAFR in the binding site with considerably good binding affinity up to - 9.8 kcal mol-1 as compared to cedrol (- 8.1 kcal mol-1) as a standard natural PAFR antagonist. The PAFR-flavonoid complexes exhibited four conserved active site residues, which included W73, F97, F174, and L279. The stability of all complexes was attained in a 30 ns simulation. The findings of in silico analyses were then compared to the experimental study on PAF inhibitory assay. Inhibitory effects of flavonoids against PAFR showed moderate activities, ranging from 27.8 – 30.8 μgM-1.Conclusion:All studied flavonoids could act as promising PAF antagonists with some enhancement in their structures to exhibit potent antagonistic activity. However, these naturally derived flavonoids demand further investigation at cellular and animal models to develop new PAF antagonist drug candidates for treating PAF-mediated diseases.
Barriers and facilitators to the management of mental health complications after mild traumatic brain injury
Authors: Silverberg Noah D , Otamendi Thalia , Dulai Amanda , Rai Ripenjot , Chhina Jason , MacLellan Anna , Lizotte Pierre-Paul 
Published: June 2021

Background: Clinical practice guidelines for mild traumatic brain injury (mTBI) management call on family physicians to proactively screen and initiate treatment for mental health complications, but evidence suggests that this does not happen consistently. The authors aimed to identify physician-perceived barriers and facilitators to early management of mental health complications following mTBI. Methods & results: Semi-structured interviews based on the Theoretical Domains Framework (TDF) were conducted with 11 family physicians. Interview transcripts were analyzed using directed content analysis. Factors influencing management of mental health post-mTBI were identified along five TDF domains. Conclusion: Family physicians could benefit from accessible and easily implemented resources to manage post-mTBI mental health conditions, having a better defined role in this process, and formalization of referrals to mental health specialists.
Prevalencia de genes qnrB, qnrA y blaTEM en bacteriófagos atemperados de Escherichia coli aislados en agua residual y alcantarillas de rastros del Estado de Méxicoesidual y alcantarillas de rastros de la zona norte del Estado de México
Authors: Talavera-González Juan Martín , Acosta-Dibarrat Jorge , Reyes-Rodríguez Nydia Edith , Salgado-Miranda Celene , Talavera-Rojas Martín 
Published: June 2021

Los genes de resistencia a los antibióticos (ARG) han sido descritos principalmente en bacterias; sin embargo, en fagos atemperados los estudios han sido escasos. En este estudio se determinó la prevalencia de los genes qnrB, qnrA y blaTEM en cepas de Escherichia coli y en fagos atemperados obtenidos por inducción del ciclo lítico en dichos aislamientos. Se recolectaron 48 muestras de agua potable, agua residual y alcantarillado en rastros del Estado de México obteniendo 37 aislamientos de E. coli. La mayor resistencia fue para tetraciclina 32/37 (86.4 %), seguido de trimetoprim-sulfametoxasol 19/37 (51.3 %) y por último ampicilina y ácido nalidíxico con el mismo número de aislamientos 18/37 (48.6 %). La prevalencia del gen blaTEM en aislamientos bacterianos fue 37.8 %, mientras que en los aislamientos fágicos fue 3.5 %. Los genes qnrA y qnrB fueron encontrado s en 8.1 % y 29.7 % respectivamente en aislamientos bacterianos, mientras que en los aislamientos fágicos fueron obtenidos 2.7 y 24.3 % respectivamente. Los resultados muestran que los ARG presentes en aislamientos bacterianos se relacionan en el ADN fágico, lo que indica el papel significativo en la propagación de ARG en los rastros estudiados. Comprender los mecanismos de resistencia a antimicrobianos, permitirá establecer medidas efectivas para disminuir este fenómeno.
Rendimiento de leche derivado de energía y proteína de vacas en pastoreo recibiendo suplementos en un sistema agrosilvopastoril
Authors: Esparza-Jiménez Sherezada , Albarran Portillo Benito , González-Ronquillo Manuel , García-Martínez Anastacio , Vázquez-Armijo José Fernando , Arriaga-Jordán Carlos Manuel 
Published: June 2021

Dual purpose farms southwest of the State of Mexico produce milk and calves under subtropical agrosilvopastoral systems (ASPS). During the dry season, farmers supplement their cattle due to the low availability and quality of grasses, without considering, besides grasses, the contribution of woody species to dry matter intake, metabolizable energy (ME), and crude protein (CP) requirements of cows. The aim of this study was to determine milk produced from forage energy (MFe) and protein (MFp) of grazing cow with three types of supplement. First supplement consisted of cracked maize and commercial concentrate resulting on 14 % of CP (S14). To the S14 mixture 7 % of soybean meal was added to increase CP to 16 % (S16), and commercial concentrate of 16 % CP was used as a third supplement (SC16). Six lactating cows were allocated in a 3x3 replicated Latin Square (three cows per square), three experimental periods (EP) (three weeks per EP). There were no significant effects of supplements (P=0.80) on performance variables. Mean milk yield was 6.8 kg/cow/d. Milk from forage energy and protein were 0.8 and 6.1 kg/cow/day, respectively. Mean milk urea nitrogen (MUN) was high regardless of supplement; but nitrogen in urine (44.1 mg/dL) and feces (1.4 mg/g) were higher for SC16 (P=0.001 and 0.04, respectively). Cows obtained 90 and 10 % of their CP and metabolizable energy requirements for maintenance and production from the agrosilvopastoral system.
Pendekatan Pluralisme Hukum dalam Studi Hukum Adat: Interaksi Hukum Adat dengan Hukum Nasional dan Internasional
Authors: Pradhani Sartika Intaning 
Published: June 2021

Scientific study on adat law starts from empirical research, which finds that adat law does not stand alone but works together with other legal orders. This paper is written based on normative legal research by collecting secondary data to answer (1) how legal pluralism explains adat law and adat law community; and (2) how the application of legal pluralism approach in adat law study. The legal pluralism approach explains adat law not as an isolated/marginalized legal order but as a dynamic legal order which interacts with national and international law. From the perspective of legal pluralism, the adat law community is a semi-autonomous social field that produces rules from the interplay between the adat law community and other legal communities/institutions. Categorization of legal pluralism approach application are as follow: first, weak legal pluralism where state law recognizes adat law either by law and regulation or court decision; second, strong legal pluralism which describes through the semi-autonomous social field, shopping forum, and forum shopping concept; third, legal pluralism multi-sited which explain the relationship between legal phenomena in local, national, and international level; and elaborate the role of information, communication, and technology which bridges legal phenomenon from one to another.
Abstrak
Kajian ilmiah terhadap hukum adat berangkat dari penelitian lapangan yang menemukan bahwa hukum adat tidak pernah berdiri sendiri dan selalu berinteraksi dengan tertib hukum yang lain. Artikel ini ditulis berdasarkan penelitian hukum normatif dengan mengumpulkan data sekunder berupa laporan-laporan penelitian dan artikel jurnal untuk untuk menjawab (1) bagaimana pendekatan pluralisme hukum menjelaskan hukum adat dan masyarakat hukum adat; dan (2) bagaiamana pendekatan pluralisme hukum digunakan dalam studi hukum adat hari ini. Pendekatan pluralisme hukum memahami hukum adat tidak sebagai suatu ketertiban hukum yang terpisah atau termarginalisasi dari ketertiban hukum yang lain, tetapi secara dinamis terus berinteraksi dengan hukum nasional maupun internasional. Dari perspektif pluralisme hukum, masyarakat hukum adat merupakan suatu wilayah sosial semi otonom yang melahirkan hukum berdasarkan hubungan saling memengaruhi dengan masyarakat hukum lain. Penerapan pendekatan pluralisme hukum dalam studi hukum adat dapat dikelompokkan dalam tiga kategori. Pertama, pluralisme hukum lemah di mana negara mengakui hukum adat baik melalui peraturan perundang-undangan maupun putusan pengadilan. Kedua, pluralisme hukum kuat yang dideskripsikan melalui konsep wilayah sosial semi-otonom, forum shopping, dan shopping forum. Terakhir, pluralisme hukum multi-sited yang digunakan untuk menjelaskan hubungan berbagai fenomena hukum antara hukum adat (lokal), nasional, dan internasional serta peran teknologi informasi dan komunikasi dalam menjembatani hubungan tersebut.
CONSIDERATION, ANALYSIS AND DEVELOPMENT OF SOME EXISTING APPROACHES TO QUANTITATIVE VALUATION OF INTANGIBLE ASSETS
Authors: Yuriy Pikalov  
Published: June 2021

Many recent scientific publications on the current and future development of the world economy highlight such a trend as the knowledge economy. It is logical to hope that if such a trend exists, it would be possible to observe the corresponding processes in changing the attractiveness of certain assets, namely the increase in the attractiveness of any assets closely related to knowledge. A similar situation would apply to innovation development, i. e., processes related to investment and R&D, etc. Data on the distribution of shares of tangible and intangible assets in the capital structure and trends in the investment attractiveness of certain assets can show the real picture. The article is devoted to the analysis of the situation of the growth of attractiveness of intangibles and intellectual capital in the conditions of intensification of innovative development and formation of knowledge economy. A comparative analysis of statistical data on investments in tangible and intangible assets in Europe, the United States and Ukraine shows that there is a tendency to increase the attractiveness of the latter types of assets. Several hypotheses have been formed, the testing of which is a necessary task of further research. Various existing approaches to the valuation of intangible and intellectual assets have been researched and systematized. It is established that the diversity of existing international approaches is reduced to several classes of patterns. Their general features, shortcomings and factors that lead to low quality of results of valuation of intangible assets or to their leveling of results are revealed. The necessity for formation of another class of estimation methods is offered and substantiated, which with necessity should be based on other, alternative principles. In general, the conceptual foundations of this class of methods are proposed and the general logical and theoretical foundations for its formation are laid. According to these principles a new class of approaches should be built according to the quasi-physical approach to the consciousness phenomena and on the principles of standardization and unification.
Sistem Informasi Pelayanan Pasien Studi Kasus Klinik Jati Husada Tangerang
Authors: Herdiansah Arief , Fitriawati Nora , Hariri Achmad 
Published: June 2021

Klinik Jati Husada merupakan salah satu klinik yang berada di kabupaten Tangerang, Dalam menjalankan operasionalnya klinik ini masih menggunakan cara kerja pencatatan data pasien dengan manual sehingga seringkali menghabat proses pelayanan dan pelaporan hasil aktifitas klinik, berdasarkan hal tersebut peneliti berinisiatif melakukan penelitian untuk membuat sebuah perancangan dan membangun sistem informasi pelayanan pasien di klinik. Peneliti menggunakan metode pengumpulan data kualitatif dan kuantitatif, dengan melakukan aktifitas observasi, wawancara dan penyebaran form survey. Peneliti menggunakan UML (Unified Modeling Language) dalam membuat pemodelan desain program berorientasi objek (OOP) dari sistem yang dikembangkan. Proses pembangunan sistem dalam penelitian ini menggunakan model pengembangan sistem waterfall dan menggunakan bahasa pemrograman PHP dalam proses pembagunan aplikasinya. Metode pengujian sistem yang digunakan dalam penelitian ini adalah black box testing dimana peneliti menguji setiap modul yang tersedia di sistem yang dikembangkan bersama-sama pengguna dan peneliti telah memperbaiki semua modul yang dirasa kurang sesuai dengan permintaan pengguna. Sistem informasi pelayanan pasien yang dihasilkan dari penelitian ini telah membantu klinik Jati Husada melakukan pengelolaan data pasien jauh lebih baik. Peneliti berharap sistem pelayanan pasien yang dibangun ini dapat menjadi referensi atau contoh bagi klinik pengobatan ditempat lain yang sejenis. AbstractJati Husada Clinic is one of the clinics in the Tangerang district. In carrying out its operations the clinic uses manual data entry and recording of patients, it holds the process of service and reporting the results of clinical activities, based on these conditions the researchers conducted research to make a design and building a patient service information system in the clinic. Researchers used qualitative and quantitative data collection methods, by conducting observation activities, interviews and distributing survey forms. Researchers use UML (Unified Modeling Language) in making object oriented program design (OOP) modeling of the developed system. The system development process in this study uses a waterfall system development model and uses the PHP programming language in the application development process. The system testing method used in this study is black box testing where the researcher and users have tested every module available in the developed system and the researcher has corrected the modules that have not been in accordance with the user's request. The patient service information system generated from this study has helped Jati Husada clinic to manage patient data much better. Researchers hope that the patient service system developed can be a reference or example for clinics in other similar places.
Analisis dan Perencangan Aplikasi E-Learning Berbasis Gamification (Studi Kasus Program Studi Sistem Informasi Institut Teknologi Kalimantan)
Authors: Putra M. Gilvy Langgawan , Octantia Hemy 
Published: June 2021

Pembelajaran pada institusi pendidikan khususnya perguruan tinggi pada era teknologi ini sebagian besar telah memanfaatkan penggunaan teknologi, seperti penggunaan power point untuk menyajikan materi dan penggunaan google classroom untuk memudahkan penyampaian berbagai file materi dan tugas. Walaupun telah menggunakan bantuan teknologi, terkadang kegiatan pembelajaran tetap dirasa membosankan bagi mahasiswa sehingga membuat motivasi belajar mahasiswa menurun. Tujuan dari penelitian ini adalah merancang sebuah aplikasi pembelajaran online atau e-learning berbasis gamification yang dapat meningkatkan motivasi belajar mahasiswa. Perancangan aplikasi dilakukan dengan metode pengembangan waterfall hingga tahap modelling. Perancangan e-learning diterapkan untuk pembagian materi, tugas, dan pelaksanaan ujian. Beberapa elemen gamification yang diterapkan pada perancangan aplikasi ini adalah challenge, reward, dan leaderboard. Sistem poin juga diterapkan pada fitur challenge dan pengguna dapat menukarkan poin tersebut dengan reward tertentu. Pada penelitian ini, dijelaskan bagaimana merancang sebuah aplikasi e-learning dengan metode gamification. Perancangan aplikasi pada penelitian ini menghasilkan 42 diagram use case, skenario use case, diagram sequence, class diagram, ERD, dan mock up aplikasi. AbstractLearning in educational institutions, especially universities in this technological era, has mostly taken advantage of the use of technology, such as the use of power points to present material and the use of google classrooms to facilitate the delivery of various material files and assignments. Even though they have used technology assistance, sometimes learning activities are still considered boring for students, so that students' learning motivation decreases. The purpose of this research is to design an online learning application or e-learning based on gamification which can increase student motivation. The application design is carried out using the waterfall development method to the modeling stage. The e-learning design is applied for the distribution of materials, assignments and exams. Some of the gamification elements applied to the design of this application are the challenges, rewards, and leaderboards. The point system is also applied to the challenge feature and users can exchange these points for certain rewards. In this paper, how to design an e-learning application with the gamification method will be explained. Application design in this paper developing 42 use case diagram, use case scenarios, sequence diagrams, class diagram, ERD, and application mock ups.