bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porcelain gallbladder and its relationship to cancer
Authors: Calomino Natale , Scheiterle Maximilian Leonardo Philip Federico , Fusario Daniele , La Francesca Noemi , Martellucci Ignazio , Marrelli Daniele 
Published: April 2021

Summary
Background
Porcelain gallbladder (PGB) is defined as calcium deposits encrusting the internal visceral layer, which becomes hard, brittle, and bluish. Porcelain gallbladder is rare and has been found in less than 1% of routine cholecystectomy specimens. Several studies report an incidence of gallbladder carcinoma (GBC) associated with gallbladder calcification varying between 12.5 and 61%, data which have been known for 60 years. There is a lack of information concerning PGB and its association with GBC, and the aim of this study is to better define this relationship.

Methods
A total of 10 patients were found to have PGB in 1050 consecutive routine surgical cholecystectomies. Clinical and laboratory findings, gallbladder histologic examination, bile culture, and bile pH were related to stone composition analysis performed by X‑ray diffraction using Perkin–Elmer (Perkin Elmer Corp. Norwalk, CT, US) 1625 FTIR.

Results
Among the 10 patients with PGB, complete calcification of the entire gallbladder wall was present in six cases, while four patients had partial calcification. Gallstones were present in all cases of PGB, multiple stones in nine cases and a single stone in one case. Bile culture was performed in all patients of the series. Among the 10 cases with PGB, culture was positive in two cases.

Conclusion
PGB is a disease as rare as it is subtle. Moreover, the chronic stimulation by stones can generate an initial dysplasia that will subsequently turn into a neoplasm: the cancerization risk is probably no different from long-standing cholesterol or combined stones, but as risk factor for cancer it requires early cholecystectomy.
Self-intersections of closed parametrized minimal surfaces in generic Riemannian manifolds
Authors: Moore John Douglas 
Published: April 2021

AbstractThis article shows that for generic choice of Riemannian metric on a compact oriented manifold M of dimension four, the tangent planes at any self-intersection $$p \in M$$

p
∈
M

of any prime closed parametrized minimal surface in M are not simultaneously complex for any orthogonal complex structure on M at p. This implies via geometric measure theory that $$H_2(M;{{\mathbb {Z}}})$$

H
2

(
M
;
Z
)

is generated by homology classes that are represented by oriented imbedded minimal surfaces.
Towards a Comprehensive View of Object-Oriented Play
Authors: Wynberg Elizabeth R. , Boland Annerieke , Raijmakers Maartje E. J. , van der Veen Chiel 
Published: April 2021

AbstractThe exploration and/or manipulation of objects and materials, referred to as object-oriented play (OOP), is one of the most prominent activities children engage in during early childhood. Especially within early childhood education, it is important to be able to assess and understand OOP, its developmental trajectory, and developmental value. This can support early childhood educators to successfully guide or enrich children’s OOP, so it becomes a context in which learning can take place. During the past decades, three dominant theoretical perspectives have explained and assessed certain (developmental) aspects of OOP: (1) genetic epistemology, (2) cultural historical psychology, and (3) evolutionary psychology. After reviewing the literature concerning OOP according to each theoretical perspective, this paper aims to synthesize these existing theories into a unified theoretical framework. This theoretical framework can be a starting point for future research on OOP in early childhood (education). We answer the following research questions: Q1. What are the defining labels and features of the exploration and/or manipulation of objects and materials by children in early childhood?; Q2. What is the developmental trajectory of the exploration and/or manipulation of objects and materials by children in early childhood?; Q3. What is the developmental value of the exploration and/or manipulation of objects and materials by children in early childhood?
Carbohydrate based meningococcal vaccines: past and present overview
Authors: Berti Francesco , Romano Maria Rosaria , Micoli Francesca , Adamo Roberto 
Published: April 2021

AbstractNeisseria meningitidis is a major cause of bacterial meningitidis worldwide. Children less than five years and adolescents are particularly affected. Nearly all invasive strains are surrounded by a polysaccharide capsule, based on which, 12 N. meningitidis serogroups are differentiated. Six of them, A, B, C, W, X, and Y, cause the vast majority of infections in humans. Mono- and multi-valent carbohydrate-based vaccines against meningococcal infections have been licensed or are currently in clinical development. In this mini-review, an overview of the past and present approaches for producing meningococcal glycoconjugate vaccines is provided.
On the Application of Magnetoacoustic Emission for a Nondestructive Assessment of the Post Welding Heat Treatment of High Chromium Steel Weld Seams
Authors: Piotrowski L. , Chmielewski M. , Golański G. , Wojsyk K. 
Published: April 2021

AbstractThe paper analyses the possibility of post weld heat treatment (PWHT) quality assessment with the help of magnetoacoustic emission (MAE) signal measurements. Two welded superheater tubes, made of high chromium VM12 steel, were analysed—as welded and heat treated one. The analysed sample in the as welded state exhibited significantly higher hardness, accompanied by a big difference in the MAE signal intensity (of order of about 50%). In order to explain that, the influence of tempering on the MAE signal intensity is demonstrated for the very similar X20CrMoV12.1 steel. It is shown that the observed increase of the MAE intensity as a function of annealing time is directly correlated with the change in hardness. The as described dependence allows to propose a method based on the MAE signal measurements as a new tool for the PWHT assessment.
Reconstitution of GABA, Glycine and Glutamate Transporters
Authors: Danbolt Niels Christian , López-Corcuera Beatriz , Zhou Yun 
Published: April 2021

AbstractIn contrast to water soluble enzymes which can be purified and studied while in solution, studies of solute carrier (transporter) proteins require both that the protein of interest is situated in a phospholipid membrane and that this membrane forms a closed compartment. An additional challenge to the study of transporter proteins has been that the transport depends on the transmembrane electrochemical gradients. Baruch I. Kanner understood this early on and first developed techniques for studying plasma membrane vesicles. This advanced the field in that the experimenter could control the electrochemical gradients. Kanner, however, did not stop there, but started to solubilize the membranes so that the transporter proteins were taken out of their natural environment. In order to study them, Kanner then had to find a way to reconstitute them (reinsert them into phospholipid membranes). The scope of the present review is both to describe the reconstitution method in full detail as that has never been done, and also to reveal the scientific impact that this method has had. Kanner’s later work is not reviewed here although that also deserves a review because it too has had a huge impact.
The adoption of drones in German agriculture: a structural equation model
Authors: Michels Marius , von Hobe Cord-Friedrich , Weller von Ahlefeld Paul Johann , Musshoff Oliver 
Published: April 2021

AbstractDrones are one of the latest tools to have been added to farmers’ precision agriculture technology tool kit. Despite the proclaimed benefits, adoption rates of drones are low and literature regarding the adoption of drones in agriculture is scarce. Therefore, this study investigates whether an extended Technology Acceptance Model (TAM) can contribute to the understanding of latent factors influencing farmers’ intention to adopt a drone. The sample of 167 German farmers was collected in 2019 via an online survey. Using partial least squares structural equation modelling and a binary model, the TAM explains 69% of the variance in the intention to use a drone by German farmers. According to the results, raising farmers’ awareness of farm-specific areas of drone application and the confidence level of using a drone can increase farmers’ intention to adopt a drone. The results are of interest for agribusinesses developing drones as well as selling or providing drones. Furthermore, the results are of interest for researchers in precision agriculture technologies.
What Should Conceptual Engineering Be All About?
Authors: Isaac Manuel Gustavo 
Published: April 2021

AbstractConceptual engineering is commonly characterized as the method for assessing and improving our representational devices. Little has been said, however, on how best to construe these representational devices—in other words, on what conceptual engineering should be all about. This paper tackles this problem with a basic strategy: First, by presenting a taxonomy of the different possible subject matters for conceptual engineering; then, by comparatively assessing them and selecting the most conducive one with a view to making conceptual engineering an actionable method, that is, a method that can be applied effectively and consistently to specific case studies. The outcome is that conceptual engineering should be all about concepts on pain of pragmatic inconsistencies otherwise.
Teilhabechancen von und Netzwerke für ältere Menschen mit Behinderungen im Quartier
Authors: Jahnke Mareen , Petersen-Ewert Corinna 
Published: April 2021

Zusammenfassung
Hintergrund
Im Zuge des demographischen Wandels steigt die Lebenserwartung von Menschen mit Behinderung. Somit nimmt auch die Anzahl von Personen mit Behinderung zu, die den Ruhestand erreichen und Unterstützung benötigen. Um ihnen Teilhabe zu ermöglichen, bedarf es eines Netzwerks im Sozialraum. Ziel der vorliegenden Studie war, Teilhabechancen zu analysieren und die Netzwerkstruktur für Menschen mit Behinderung im Senior*innenalter in vier Hamburger Stadtteilen aufzuzeigen.

Methodik
In einer Vorstudie wurden 27 Einzelinterviews mit Menschen mit Behinderung durchgeführt. Ausgehend von den Ergebnissen der Vorstudie fanden acht Fokusgruppeninterviews mit Akteuren aus dem Bereich der Behindertenhilfe und aus den jeweiligen Stadtteilen statt. Um die stadtteilbezogene Netzwerkstruktur sichtbar zu machen, erfolgte eine Online-Befragung mit 86 Akteuren, die mit einem Träger der Behindertenhilfe, der Leben mit Behinderung Hamburg Sozialeinrichtungen gemeinnützige GmbH, kooperieren.

Ergebnisse
Bezüglich der Teilhabechancen von Menschen mit Behinderung im Senior*innenalter wurde ein Bedarf für eine professionelle Begleitung im Alltag ergänzt durch ehrenamtliche Pat*innen identifiziert. Aufsuchende Beratungs- und Versorgungsangebote könnten zur Förderung der Gesundheit von Menschen mit Behinderung beitragen. Bei der Konzeption dieser Angebote sollten die Adressat*innen beteiligt werden. Zudem wäre eine professionelle Koordination notwendig, um die Vernetzung der Angebote, Akteure und Menschen mit/ohne Behinderung im Stadtteil zu stärken.

Schlussfolgerung
Die Ergebnisse unterstreichen, dass eine sozialraumorientierte Arbeitsweise unter Einbezug der Akteure und im Stadtteil lebender Menschen mit und ohne Behinderung bei der Gestaltung der Lebensbedingungen die Teilhabechancen aller fördern kann.
Die dunkle Seite der Vorstellungskraft: Das Abjekt als Verworfenes im Imaginären
Authors: Pfaller Larissa 
Published: April 2021

ZusammenfassungDie sich derzeitig konstituierende Soziologie des Imaginären nimmt dieses in erster Linie über die Rekonstruktion bedeutungstragender Vorstellungsinhalte in den Blick. Demgegenüber bleibt dasjenige, was im Imaginären verworfen wird, außerhalb empirischer Forschung wie theoretischer Betrachtungen. Um diese Lücke zu schließen, schlägt der Artikel den Begriff des Abjekts vor, dessen analytisches Potenzial für die Soziologie bisher ungenutzt bleibt. Am Beispiel des Phänomens des vierten Alters wird anschließend vorgeführt, wie eine Analyse des Abjekts systematisch für die Rekonstruktion des sozialen Imaginären nutzbar gemacht werden kann. Im Sinne einer Soziologie des Exzeptionellen plädiert der Artikel abschließend dafür, auch das soziale Imaginäre stets von seinen Grenzen aus zu denken.
REMAXINT: a two-mode clustering-based method for statistical inference on two-way interaction
Authors: Ahmed Zaheer , Cassese Alberto , van Breukelen Gerard , Schepers Jan 
Published: April 2021

AbstractWe present a novel method, REMAXINT, that captures the gist of two-way interaction in row by column (i.e., two-mode) data, with one observation per cell. REMAXINT is a probabilistic two-mode clustering model that yields two-mode partitions with maximal interaction between row and column clusters. For estimation of the parameters of REMAXINT, we maximize a conditional classification likelihood in which the random row (or column) main effects are conditioned out. For testing the null hypothesis of no interaction between row and column clusters, we propose a$$max-F$$max-Ftest statistic and discuss its properties. We develop a Monte Carlo approach to obtain its sampling distribution under the null hypothesis. We evaluate the performance of the method through simulation studies. Specifically, for selected values of data size and (true) numbers of clusters, we obtain critical values of the$$max-F$$max-Fstatistic, determine empirical Type I error rate of the proposed inferential procedure and study its power to reject the null hypothesis. Next, we show that the novel method is useful in a variety of applications by presenting two empirical case studies and end with some concluding remarks.
Glucose metabolism outcomes in acromegaly patients on treatment with pasireotide-LAR or pasireotide-LAR plus Pegvisomant
Authors: Chiloiro Sabrina , Giampietro Antonella , Visconti Felicia , Rossi Laura , Donfrancesco Federico , Fleseriu Cara M. , Mirra Federica , Pontecorvi Alfredo , Giustina Andrea , Fleseriu Maria , De Marinis Laura , Bianchi Antonio 
Published: April 2021

Abstract
Introduction
Disorders of glucose metabolism are a serious acromegaly comorbidity and may be differently impacted by medical treatments of acromegaly. In this retrospective longitudinal multicenter study, we investigated the outcome of glucose metabolism and its predictors in patients treated with Pasireotide LAR (PAS-LAR) alone or in combination with Pegvisomant (PAS-LAR + Peg-V).

Subjects and methods
Acromegaly patients treated continously with PAS-LAR or PAS-LAR + Peg-V for at least 6 months.

Results
Forty patients (25 females, 15 males) were enrolled. At last visit, 27/40 patients (67.5%) reached biochemical control of acromegaly. Overall, glucose metabolism improved in 3 (all in PAS-LAR + Peg-V; 7.5%), worsened in 26 (65%) and remained unchanged in 11 patients (27.5%). Glucose metabolism worsened in 25 patients (73.5%) treated with PAS-LAR and in a single patient (16.7%) treated with PAS-LAR + Peg-V (p < 0.001). Among patients treated with Pas-LAR alone, GH at baseline was higher in those with worsening of glucose metabolism (p = 0.04) as compared to those with stable glucose status. A significantly higher reduction of HbA1c was observed in patients treated with PAS-LAR + Peg-V, as compared with those treated with PAS-LAR alone (p = 0.005).

Conclusions
Our data confirmed that glucose metabolism in patients treated with PAS-LAR is often worsened, and may be predicted by entity of baseline GH hypersecretion and by the dose of PAS-LAR. Moreover, our data, although limited by small numbers, may suggest that the combination treatment PAS-LAR + Peg-V can improve glucose homeostasis in selected patients.
The Role of Nonduality in the Relationship Between Flow States and Well-Being
Authors: Lynch Julianna M. , Troy Allison S. 
Published: April 2021

Abstract
Objectives
The current study investigated the hypothesis that the relationship between flow states and well-being is mediated by nondual experiences. Past empirical and theoretical work suggests flow states share similarities with nondual experiences. The current study expanded upon previous work by examining the relationships between flow, nondual experiences, emotion, and well-being.

Methods
Students enrolled in various artistic classes (N = 104) were surveyed once a week for four weeks. Participants reported on their experiences of flow, nonduality, emotion, and psychological and subjective well-being.

Results
Higher scores on measures of both flow (b = 7.03, SE = 0.82, p < .001) and nondual experiences (b = 0.17, SE = 0.02, p < .001) predicted increased positive emotion immediately after class. Nondual experiences partially mediated this relationship, such that when accounting for nondual experiences, the relationship between flow and positive emotion was significantly decreased (b = 4.30, SE = 0.45, p < .001). Longitudinally, nondual experience also mediated the relationship between flow and satisfaction with life (Sobel t = 1.94, SE = 1.06, p = .05). However, while flow predicted increased psychological well-being (b = 0.32, SE = 0.14, p = .02) after the four weeks, nondual experience did not (b = −0.003, SE = 0.002, p = .13).

Conclusions
These findings suggest that flow states may facilitate some features of nonduality and share similarities with meditative states. Additionally, the link between flow and well-being may be explained by its similarities to meditative states, and that creative activities could be useful in fostering well-being.
On some Fournier–Gagliardo type inequalities
Authors: Kolyada V. I. 
Published: April 2021

AbstractIn this paper we consider nonnegative functionsfon$$\mathbb {R}^n$$Rnwhich are defined either by$$f(x)=\min \,(f_1(x_1),\ldots ,f_n(x_n))$$f(x)=min(f1(x1),…,fn(xn))or by$$f(x)=\min \,(f_1(\hat{x}_1),\ldots ,f_n(\hat{x}_n)).$$f(x)=min(f1(x^1),…,fn(x^n)).Such minimum-functions are useful, in particular, in embedding theorems. We prove sharp estimates of rearrangements and Lorentz type norms for these functions, and we find the link between their Lorentz norms and geometric properties of their level sets.
A novel approach to optimize the production cost of railway coaches of India using situational-based composite triangular and trapezoidal fuzzy LPP models
Authors: Kumar Rakesh , Dhiman Gaurav , Kumar Neeraj , Chandrawat Rajesh Kumar , Joshi Varun , Kaur Amandeep 
Published: April 2021

AbstractThis article offers a comparative study of maximizing and modelling production costs by means of composite triangular fuzzy and trapezoidal FLPP. It also outlines five different scenarios of instability and has developed realistic models to minimize production costs. Herein, the first attempt is made to examine the credibility of optimized cost via two different composite FLP models, and the results were compared with its extension, i.e., the trapezoidal FLP model. To validate the models with real-time phenomena, the Production cost data of Rail Coach Factory (RCF) Kapurthala has been taken. The lower, static, and upper bounds have been computed for each situation, and then systems of optimized FLP are constructed. The credibility of each model of composite-triangular and trapezoidal FLP concerning all situations has been obtained, and using this membership grade, the minimum and the greatest minimum costs have been illustrated. The performance of each composite-triangular FLP model was compared to trapezoidal FLP models, and the intense effects of trapezoidal on composite fuzzy LPP models are investigated.
Nanoscale nonlinear plasmonics in photonic waveguides and circuits
Authors: Tuniz Alessandro 
Published: April 2021

AbstractOptical waveguides are the key building block of optical fiber and photonic integrated circuit technology, which can benefit from active photonic manipulation to complement their passive guiding mechanisms. A number of emerging applications will require faster nanoscale waveguide circuits that produce stronger light-matter interactions and consume less power. Functionalities that rely on nonlinear optics are particularly attractive in terms of their femtosecond response times and terahertz bandwidth, but typically demand high powers or large footprints when using dielectrics alone. Plasmonic nanostructures have long promised to harness metals for truly nanoscale, energy-efficient nonlinear optics. Early excitement has settled into cautious optimism, and recent years have been marked by remarkable progress in enhancing a number of photonic circuit functions with nonlinear plasmonic waveguides across several application areas. This work presents an introductory review of nonlinear plasmonics in the context of guided-wave structures, followed by a comprehensive overview of related experiments and applications covering nonlinear light generation, all-optical signal processing, terahertz generation/detection, electro optics, quantum optics, and molecular sensing.
Developing MXenes from Wireless Communication to Electromagnetic Attenuation
Authors: He Peng , Cao Mao-Sheng , Cao Wen-Qiang , Yuan Jie 
Published: April 2021

Abstract
There is an urgent global need for wireless communication utilizing materials that can provide simultaneous flexibility and high conductivity. Avoiding the harmful effects of electromagnetic (EM) radiation from wireless communication is a persistent research hot spot. Two-dimensional (2D) materials are the preferred choice as wireless communication and EM attenuation materials as they are lightweight with high aspect ratios and possess distinguished electronic properties. MXenes, as a novel family of 2D materials, have shown excellent properties in various fields, owing to their excellent electrical conductivity, mechanical stability, high flexibility, and ease of processability. To date, research on the utility of MXenes for wireless communication has been actively pursued. Moreover, MXenes have become the leading materials for EM attenuation. Herein, we systematically review the recent advances in MXene-based materials with different structural designs for wireless communication, electromagnetic interference (EMI) shielding, and EM wave absorption. The relationship governing the structural design and the effectiveness for wireless communication, EMI shielding, and EM wave absorption is clearly revealed. Furthermore, our review mainly focuses on future challenges and guidelines for designing MXene-based materials for industrial application and foundational research.
MoS2-Decorated/Integrated Carbon Fiber: Phase Engineering Well-Regulated Microwave Absorber
Authors: Yan Jing , Huang Ying , Zhang Xiangyong , Gong Xin , Chen Chen , Nie Guangdi , Liu Xudong , Liu Panbo 
Published: April 2021

AbstractPhase engineering is an important strategy to modulate the electronic structure of molybdenum disulfide (MoS2). MoS2-based composites are usually used for the electromagnetic wave (EMW) absorber, but the effect of different phases on the EMW absorbing performance, such as 1T and 2H phase, is still not studied. In this work, micro-1T/2H MoS2 is achieved via a facile one-step hydrothermal route, in which the 1T phase is induced by the intercalation of guest molecules and ions. The EMW absorption mechanism of single MoS2 is revealed by presenting a comparative study between 1T/2H MoS2 and 2H MoS2. As a result, 1T/2H MoS2 with the matrix loading of 15% exhibits excellent microwave absorption property than 2H MoS2. Furthermore, taking the advantage of 1T/2H MoS2, a flexible EMW absorbers that ultrathin 1T/2H MoS2 grown on the carbon fiber also performs outstanding performance only with the matrix loading of 5%. This work offers necessary reference to improve microwave absorption performance by phase engineering and design a new type of flexible electromagnetic wave absorption material to apply for the portable microwave absorption electronic devices.