bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Asymmetric Hydrogel with Integrated Multi‐Functions of NIR‐Triggered Tunable Adhesion, Self‐Deformation, and Bacterial Eradication
Authors: Feng Lan , Shi Wenbin , Chen Qin , Cheng Huitong , Bao Jianxu , Jiang Chunji , Zhao Weifeng , Zhao Changsheng 
Published: May 2021

AbstractMultifunctional hydrogels acting as wound dressing have received extensive attention in soft tissue repair; however, it is still a challenge to develop a non‐antibiotic‐dependent antibacterial hydrogel that has tunable adhesion and deformation to achieve on‐demand removal. Herein, an asymmetric adhesive hydrogel with near‐infrared (NIR)‐triggered tunable adhesion, self‐deformation, and bacterial eradication is designed. The hydrogel is prepared by the crosslinking polymerization of N‐isopropylacrylamide and acrylic acid, during the sedimentation of conductive PPy‐PDA nanoparticles based on the polymerization of pyrrole (Py) and dopamine (DA). Due to the conversion capacity from NIR light into heat for PPy‐PDA NPs, the formed temperature‐sensitive hydrogel exhibits tissue adhesive as well as NIR‐triggered tunable adhesion and self‐deformation property, which can achieve an on‐demand dressing refreshing. Systematically in vitro/in vivo antibacterial experiments indicate that the hydrogel shows excellent disinfection capability to both Gram‐negative and Gram‐positive bacteria. The in vivo experiments in a full‐layer cutaneous wound model demonstrate that the hydrogel has a good treatment effect to promote wound healing. Overall, the asymmetric hydrogel with tunable adhesion, self‐deformation, conductive, and photothermal antibacterial activity may be a promising candidate to fulfill the functions of adhesion on skin tissue, easy removing on‐demand, and accelerating the wound healing process.
2D III‐Nitride Materials: Properties, Growth, and Applications
Authors: Ben Jianwei , Liu Xinke , Wang Cong , Zhang Yupeng , Shi Zhiming , Jia Yuping , Zhang Shanli , Zhang Han , Yu Wenjie , Li Dabing , Sun Xiaojuan 
Published: May 2021

Abstract2D III‐nitride materials have been receiving considerable attention recently due to their excellent physicochemical properties, such as high stability, wide and tunable bandgap, and magnetism. Therefore, 2D III‐nitride materials can be applied in various fields, such as electronic and photoelectric devices, spin‐based devices, and gas detectors. Although the developments of 2D h‐BN materials have been successful, the fabrication of other 2D III‐nitride materials, such as 2D h‐AlN, h‐GaN, and h‐InN, are still far from satisfactory, which limits the practical applications of these materials. In this review, recent advances in the properties, growth methods, and potential applications of 2D III‐nitride materials are summarized. The properties of the 2D III‐nitride materials are mainly obtained by first‐principles calculations because of the difficulties in the growth and characterizations of these materials. The discussion on the growth of 2D III‐nitride materials is focused on 2D h‐BN and h‐AlN, as the developments of 2D h‐GaN and h‐InN are yet to be realized. Therefore, applications have been realized mostly based on the 2D h‐BN materials; however, many potential applications are cited for the entire range of 2D III‐nitride materials. Finally, future research directions and prospects in this field are also discussed.
Comprehensive Understandings into Complete Reconstruction of Precatalysts: Synthesis, Applications, and Characterizations
Authors: Liu Xiong , Meng Jiashen , Zhu Jiexin , Huang Meng , Wen Bo , Guo Ruiting , Mai Liqiang 
Published: May 2021

AbstractReconstruction induced by external environment (such as applied voltage bias and test electrolytes) changes catalyst component and catalytic behaviors. Investigations of complete reconstruction in energy conversion recently receive intensive attention, which promote the targeted design of top‐performance materials with maximum component utilization and good stability. However, the advantages of complete reconstruction, its design strategies, and extensive applications have not achieved the profound understandings and summaries it deserves. Here, this review systematically summarizes several important advances in complete reconstruction for the first time, which includes 1) fundamental understandings of complete reconstruction, the characteristics and advantages of completely reconstructed catalysts, and their design principles, 2) types of reconstruction‐involved precatalysts for oxygen evolution reaction catalysis in wide pH solution, and origins of limited reconstruction degree as well as design strategies/principles toward complete reconstruction, 3) complete reconstruction for novel material synthesis and other electrocatalysis fields, and 4) advanced in situ/operando or multiangle/level characterization techniques to capture the dynamic reconstruction processes and real catalytic contributors. Finally, the existing major challenges and unexplored/unsolved issues on studying the reconstruction chemistry are summarized, and an outlook for the further development of complete reconstruction is briefly proposed. This review will arouse the attention on complete reconstruction materials and their applications in diverse fields.
Recent Advances in Engineered Materials for Immunotherapy‐Involved Combination Cancer Therapy
Authors: Liang Jun‐Long , Luo Guo‐Feng , Chen Wei‐Hai , Zhang Xian‐Zheng 
Published: May 2021

AbstractImmunotherapy that can activate immunity or enhance the immunogenicity of tumors has emerged as one of the most effective methods for cancer therapy. Nevertheless, single‐mode immunotherapy is still confronted with several critical challenges, such as the low immune response, the low tumor infiltration, and the complex immunosuppression tumor microenvironment. Recently, the combination of immunotherapy with other therapeutic modalities has emerged as a powerful strategy to augment the therapeutic outcome in fighting against cancer. In this review, recent research advances of the combination of immunotherapy with chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, metabolic therapy, and microwave thermotherapy are summarized. Critical challenges and future research direction of immunotherapy‐based cancer therapeutic strategy are also discussed.
Two‐Dimensional Silicene/Silicon Nanosheets: An Emerging Silicon‐Composed Nanostructure in Biomedicine
Authors: Ma Lifang , Song Xinran , Yu Yongchun , Chen Yu 
Published: May 2021

AbstractSilicon‐composed nanomedicines are one of the most representative inorganic nanosystems in theranostic biomedicine. The emerging of new family members of silicon‐composed nanosystems substantially contributes to their further clinical translation. 2D silicene/silicon nanosheets have recently been developed as an emerging topology of silicon‐composed nanoparticles, which features unique planar nanostructure with large surface area, abundant surface chemistry, specific physiochemical property, and desirable biological effects. This progress report highlights and discusses the state‐of‐art developments of the elaborate construction of 2D silicene/silicon nanosheets for versatile biomedical applications, including top–down fabrication, multifunctionalization, surface engineering, and their available biomedical applications in tumor theranostics (e.g., bioimaging, photothermal ablation, chemotherapy, chemoreactive nanotherapy, radiotherapy, and synergistic nanotherapy) and antibacteria. Their large surface area originating from 2D nanostructure not only enables efficient loading and delivery of chemotherapeutic drugs, but also guarantees the multifunctionalization. Especially, 2D silicene/silicon nanosheets harness desirable photothermal‐conversion performance for photonic hyperthermia and photoacoustic imaging in the near infrared biowindow, accompanied with the desirable biodegradability and biocompatibility, which is typically not possessed in other silicon‐composed counterparts. The multivariate analysis on the facing challenges and future developments of these 2D silicene/silicon nanosheets have also been conducted and outlooked for further underpinning their clinical translations.
Palladium‐Catalyzed Diastereoselective Synthesis of (Z)‐Conjugated Enynyl Homoallylic Alcohols
Authors: Horino Yoshikazu , Ishibashi Mayo , Sakamoto Juri , Murakami Miki , Korenaga Toshinobu 
Published: May 2021

AbstractThe diastereoselective synthesis of anti‐homoallylic alcohols bearing conjugated (Z)‐enynes through a palladium‐catalyzed three‐component reaction is described. This reaction features a broad substrate scope, good functional group compatibility, and high levels of (Z)‐alkene stereocontrol. In this reaction, Pd(0) functions as a catalyst in two fundamental steps of the tandem sequence: 1) the generation of a borylated π‐allylpalladium species from bifunctional conjunctive reagents, inducing umpolung allylation of aldehydes, and 2) C(sp2)−C(sp) cross‐coupling. Further transformations of the obtained products highlight their synthetic utility.magnified image
Preparation and Utilization of Contiguous Bisaziridines as Chiral Building Blocks
Authors: Rhee Hyong‐Jin , Ranjith Jala , Byeon Huimyoung , Ha Hyun‐Joon , Yang Jung Woon 
Published: May 2021

AbstractChiral contiguous bisaziridines were prepared by the aziridination of chiral 3‐[1‐(1‐phenylethyl)aziridin‐2‐yl)]acrylaldehydes with either N‐Boc‐O‐tosyl or N‐Ts‐O‐tosyl hydroxylamine as a nitrogen source and (2R)‐ or (2S)‐[diphenyl(trimethylsilyloxy)methyl]pyrrolidine as a chiral organocatalyst. The regioselective ring opening of bisaziridines afforded chiral nitrogen‐rich molecules.magnified image
Low‐Power Memristive Logic Device Enabled by Controllable Oxidation of 2D HfSe2 for In‐Memory Computing
Authors: Liu Long , Li Yi , Huang Xiaodi , Chen Jia , Yang Zhe , Xue Kan‐Hao , Xu Ming , Chen Huawei , Zhou Peng , Miao Xiangshui 
Published: May 2021

AbstractMemristive logic device is a promising unit for beyond von Neumann computing systems and 2D materials are widely used because of their controllable interfacial properties. Most of these 2D memristive devices, however, are made from semiconducting chalcogenides which fail to gate the off‐state current. To this end, a crossbar device using 2D HfSe2 is fabricated, and then the top layers are oxidized into “high‐k” dielectric HfSexOy via oxygen plasma treatment, so that the cell resistance can be remarkably increased. This two‐terminal Ti/HfSexOy/HfSe2/Au device exhibits excellent forming‐free resistive switching performance with high switching speed (<50 ns), low operation voltage (<3 V), large switching window (103), and good data retention. Most importantly, the operation current and the power consumption reach 100 pA and 0.1 fJ to 0.1 pJ, much lower than other HfO based memristors. A functionally complete low‐power Boolean logic is experimentally demonstrated using the memristive device, allowing it in the application of energy‐efficient in‐memory computing.
A 3D Fiber‐Hydrogel Based Non‐Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury
Authors: Zhang Na , Lin Junquan , Lin Vincent Po Hen , Milbreta Ulla , Chin Jiah Shin , Chew Elaine Guo Yan , Lian Michelle Mulan , Foo Jia Nee , Zhang Kunyu , Wu Wutian , Chew Sing Yian 
Published: May 2021

AbstractCurrent treatment approaches toward spinal cord injuries (SCI) have mainly focused on overcoming the inhibitory microenvironment that surrounds lesion sites. Unfortunately, the mere modulation of the cell/tissue microenvironment is often insufficient to achieve desired functional recovery. Therefore, stimulating the intrinsic growth ability of injured neurons becomes crucial. MicroRNAs (miRs) play significant roles during axon regeneration by regulating local protein synthesis at growth cones. However, one challenge of using miRs to treat SCI is the lack of efficient delivery approaches. Here, a 3D fiber‐hydrogel scaffold is introduced which can be directly implanted into a spinal cord transected rat. This 3D scaffold consists of aligned electrospun fibers which provide topographical cues to direct axon regeneration, and collagen matrix which enables a sustained delivery of miRs. Correspondingly, treatment with Axon miRs (i.e., a cocktail of miR‐132/miR‐222/miR‐431) significantly enhances axon regeneration. Moreover, administration of Axon miRs along with anti‐inflammatory drug, methylprednisolone, synergistically enhances functional recovery. Additionally, this combined treatment also decreases the expression of pro‐inflammatory genes and enhance gene expressions related to extracellular matrix deposition. Finally, increased Axon miRs dosage with methylprednisolone, significantly promotes functional recovery and remyelination. Altogether, scaffold‐mediated Axon miR treatment with methylprednisolone is a promising therapeutic approach for SCI.
1/f Noise Characterization of Bilayer MoS2 Field‐Effect Transistors on Paper with Inkjet‐Printed Contacts and hBN Dielectrics
Authors: Pimpolari Lorenzo , Calabrese Gabriele , Conti Silvia , Worsley Robyn , Majee Subimal , Polyushkin Dmitry K. , Paur Matthias , Casiraghi Cinzia , Mueller Thomas , Iannaccone Giuseppe , Macucci Massimo , Fiori Gianluca 
Published: May 2021

Abstract1/f noise represents the dominant source of noise in the low‐frequency range in several physical systems, including field‐effect transistors. Its investigation can provide very important information on the fabrication process, highlighting the steps that are more prone to the introduction of defects. Here, 1/f noise in bilayer MoS2 transistors on paper with inkjet‐printed Ag contacts and hBN dielectric is investigated. These devices are promising building blocks for future low‐cost, flexible, and easily recyclable disposable electronics. The analysis of 1/f noise, performed following Hooge's empirical approach, results in a Hooge parameter ≈1–10, which is comparable to those reported for bilayer MoS2 transistors on SiO2. The present results indicate that the noise properties of the investigated devices are stable against substrate bending and are mainly determined by the printing of the dielectric, while not being sensibly affected by the use of the paper substrate. These results are promising for the further development of low noise 2D material‐based flexible electronics on paper.
Seed coating by biofertilizer containing spores of Bacillus pumilus TUAT1 strain enhanced initial growth of Oryza sativa L.
Authors: Agake Shin‐ichiro , Artigas Ramirez Maria Daniela , Kojima Katsuhiro , Ookawa Taiichiro , Ohkama‐Ohtsu Naoko , Yokoyama Tadashi 
Published: May 2021

AbstractIn rice production, early growth is often slow in direct‐seeded system. Techniques to overcome this barrier are needed. This study evaluated the effectiveness of Kikuichi—a biofertilizer containing Bacillus pumilus TUAT1 spore—in promoting rice growth in a direct‐sowing system. Oxygen, iron, and molybdenum as coating materials were also evaluated to combine with biofertilizer. The seeds were coated with powdered Kikuichi with polyvinyl alcohol followed by a coating with calcium peroxide (CALPER), molybdenum (Benmoly), and iron powder. Double coating with the biofertilizer and Benmoly promoted plant growth. We applied amounts of Kikuichi equivalent to one, two and a half, and five times the weight of the seeds and found that the growth‐promoting effect was dependent on the amount applied. The best timing of application of the coating, specifically during sprouting, was before the coleoptile emerged. Bacillus pumilus TUAT1 can enhance the growth of rice when it exists in high concentration on the spermosphere by coating with molybdenum, but double coating with neither calcium peroxide nor iron powder contributed to the initial growth of the seeds. Kikuichi coating with Benmoly has positive effects on the rice growth. This coating method is suitable to apply biofertilizer for direct sowing cultivation of rice.
WAASB‐based stability analysis and simultaneous selection for grain yield and early maturity in soybean
Authors: Nataraj Vennampally , Bhartiya Anuradha , Singh Chandra Pratap , Devi Heisnam Nanita , Deshmukh Milind Panjabrao , Verghese Philips , Singh Kamendra , Mehtre Shivaji Pandurang , Kumari Vedna , Maranna Shivakumar , Kumawat Giriraj , Ratnaparkhe Milind B , Satpute Gyanesh K , Rajesh Vangala , Chandra Subhash , Ramteke Rajkumar , Khandekar Nita , Gupta Sanjay 
Published: May 2021

AbstractSoybean [Glycine max (L.) Merr.] is the leading Indian oilseed crop grown under rainfed conditions. Meticulous understanding of genotype × environment interaction patterns is essential to develop superior and widely adaptable soybean varieties. In the current study, 32 soybean genotypes were evaluated at eight locations for two consecutive years. Additive main effect and multiplicative interaction ANOVA revealed that only 41.6% of variance was explained by the first two interaction principal component axes (IPCAs), leaving 58.4% to the remaining 13 IPCs. The weighted average of absolute scores (WAASB) stability index, a best linear unbiased prediction–based mixed model that takes in to account all the IPCAs, has been used in stability analysis. SL1171 (WAASB score, 4.09) was found to be highly stable among the genotypes under study, with grain yield (2,050.87 kg ha−1) lower than the grand mean (2,082.50 kg ha−1). A superiority index that allows weighting between mean performance and stability (WAASBY) was used to select stable and high yielding genotypes. MACS 1620 (WAASBY score, 74.47) was found to be high yielding (2,476.05 kg ha−1) and widely adaptable. A simultaneous selection index (i.e., multi‐trait stability index [MTSI]) has been used for selecting early‐maturing and high‐yielding genotypes. DSb 33 was found to have the lowest MTSI (0.001) and can be used as a parent for breeding for early maturity and higher yield. The 100‐seed weight was found to be positively correlated with grain yield and can be used in direct selection for grain yield. Through genotypic cluster analysis, NRC 146 was found to be more divergent, with the highest mean 100 seed weight (16.39 g), and therefore can be used as a parent for breeding solely for grain yield.
Clinical spectrum of individuals with de novo EBF3 variants or deletions
Authors: Nishi Eriko , Uehara Tomoko , Yanagi Kumiko , Hasegawa Yuiko , Ueda Kimiko , Kaname Tadashi , Yamamoto Toshiyuki , Kosaki Kenjiro , Okamoto Nobuhiko 
Published: May 2021

AbstractHypotonia, ataxia and delayed development syndrome (HADDS) (MIM#617330) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in EBF3 (MIM; 607,407), which is located on chromosome 10q26, and was first reported in 2017. To date, missense, nonsense and frameshift variants have been reported as causes of HADDS, and EBF3 pathogenic variants have been predicted to result in nonsense‐mediated mRNA decay and haploinsufficiency. It was also reported that total deletion of EBF3 associated with a 10q26.3 microdeletion also causes HADDS symptoms, supporting the concept that HADDS results from haploinsufficiency of EBF3. Here, we report eight unrelated individuals with heterozygous pathogenic variants of EBF3 or haploinsufficiency of EBF3 due to 10q26 deletion, who exhibit clinical findings including craniofacial features of HADDS. In a detailed examination of clinical manifestations in this study, revealed that neurogenic bladder was diagnosed in infancy (the median 6.5 months), was more frequent than previously reported, and required cystostomy in all but one case. For psychomotor delay, it was also found that their motor/skills values were significantly lower than their cognition/adaptation values (p = 0.0016; paired t‐test). Therefore, that HADDS is a recognizable syndrome that shares its characteristic facial features, and that neurogenic bladder diagnosed in infancy and psychomotor delay with marked delay in motor/skills are noteworthy findings in the diagnosis and management of individuals with HADDS.
Beta‐amyloid pore linked to controlled calcium influx into the cell: A new paradigm for Alzheimer's Disease
Authors: Pannuzzo Martina 
Published: May 2021

AbstractDespite tremendous worldwide efforts, clinical trials assessing Alzheimer's disease (AD)‐related therapeutics have been relentlessly unsuccessful. Hence, there is an urgent need to challenge old hypotheses with novel paradigms. An emerging concept is that the amyloid‐beta (Aβ) peptide, which was until recently deemed a major player in the cause of AD, may instead modulate synaptic plasticity and protect against excitotoxicity. The link between Aβ‐mediated synaptic plasticity and Aβ trafficking is central for understanding AD pathogenesis and remains a perplexing relationship. The crossover between Aβ pathological and physiological roles is subtle and remains controversial. Based on existing literature, as a signaling molecule, Aβ is proposed to modulate its own turnover and synaptic plasticity through what is currently believed to be the cause of AD: the transient formation of pore‐like oligomers. A change of perspective regarding how Aβ pores exert a protective function will unavoidably revolutionize the entire field of anti‐amyloid drug development.
Effect of periodontal treatment on preclinical Alzheimer's disease—Results of a trial emulation approach
Authors: Schwahn Christian , Frenzel Stefan , Holtfreter Birte , Van der Auwera Sandra , Pink Christiane , Bülow Robin , Friedrich Nele , Völzke Henry , Biffar Reiner , Kocher Thomas , Grabe Hans Jörgen ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: May 2021

AbstractIntroductionWe investigated the relationship between periodontal treatment and pre‐clinical Alzheimer's disease (AD).MethodsIn this quasi‐experimental design, 177 periodontally treated patients from the “Greifswald Approach to Individualized Medicine” cohort, which used the same protocols as the population‐based Study of Health in Pomerania TREND (SHIP‐TREND), and 409 untreated subjects from SHIP‐TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late‐onset AD and brain aging were used as the outcomes.ResultsRobust to sensitivity analyses, periodontal treatment had a favorable effect on AD‐related brain atrophy (–0.41; 95% confidence interval: –0.70 to –0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.ConclusionPeriodontitis is related to pre‐clinical AD in our population.
Photoactivated In Situ Generation of Near Infrared Cyanines for Spatiotemporally Controlled Fluorescence Imaging in Living Cells
Authors: Song Gang , Heng Hao , Wang Jiaqi , Liu Ronghua , Huang Yiming , Lu Huan , Du Ke , Feng Fude , Wang Shu 
Published: May 2021

AbstractPhotoactivated trimerization of 2,3,3‐trimethyl‐3H‐indole derivatives created near infrared fluorophore Cy5. The synthetic method is air‐tolerant, photosensitizer free, metal free, and condensation agent free. Living cells make Cy5 on a time scale of minutes under white light irradiation at a low power intensity, with the monomer as the only exogenous agent. The new method is promising to find applications in cell studies for in situ spatiotemporally controlled fluorescence imaging in living cells.