bluuebunny/crossref_metadata_2025_split huggingface dataset:
Images of Science: A Reality Check
Authors: Miedema Frank 
Published: October 2021

AbstractIt will be argued that the dominant form of current academic science is based on ideas and concepts about science and research that date back to philosophy and sociology that was developed since the 1930s. It will be discussed how this philosophy and sociology of science has informed the ideas, myths and ideology about science held by the scientific community and still determines the popular view of science. It is even more amazing when we realize that these ideas are philosophically and sociologically untenable and since the 1970s were declared obsolete by major scholars in these same disciplines. To demonstrate this, I delve deep to discuss the distinct stages that scholars in philosophy, sociology and history of science since 1945 to 2000 have gone through to leave the analytical-positivistic philosophy behind. I will be focusing on developments of their thinking about major topics such as: how scientific knowledge is produced, the scientific method; the status of scientific knowledge and the development of our ideas about ‘truth’ and the relation of our claims to reality. It will appear that the positivistic ideas about science producing absolute truth, about ‘the unique scientific method’, its formal logical approach and its timeless foundation as a guarantee for our value-free, objective knowledge were not untenable. This is to show how thoroughly the myth has been demystified in philosophy and sociology of science. You think after these fifty pages I am kicking a dead horse? Not at all! This scientific demystification has unfortunately still not reached active scientists. In fact, the popular image of science and research is still largely based on a that Legend. This is not without consequence as will be shown in Chap. 3. These images of science have shaped and in fact distorted the organisational structures of academia and the interaction between its institutes and disciplines. It also affects the relationship of science with its stakeholders in society, its funders, the many publics private and public, and policy makers in government. In short, it determines to a large degree the growth of knowledge with major effects on society.
Science in Social Contexts
Authors: Miedema Frank 
Published: October 2021

AbstractGradually since 1990 a growing number of critical analyses from within science have been published of how science was organized as a system and discussing its problems, despite, or paradoxically because the growing size of its endeavour and its growing yearly output. Because of lack of openness with regards to sharing results of research, such as publications and data but in fact of all sorts of other products, science is felt by many to be disappointing with respect to its societal impact, its contribution to the major problems humanity is facing in the current times. With the financial crisis, in analogy, also the crisis of the academic system as described in Chap.3was exposed and it seemed that similar systemic neoliberal economic mechanisms operated in these at first sight seemingly different industries. Most of these critiques appeared with increasing frequency since 2014 in formal scientific magazines, social media and with impact reached the leadership of universities, government and funders. This raised awareness and support for the development of new ways of doing science, mostly intuitively and implicitly, but sometimes explicitly motivated by pragmatism aiming for societal progress and contribution to the good life.To get to this next level we need the critical reflection on the practice of science as done in previous chapters in order to make systemic changes to several critical parts of the knowledge production chain. I will discuss the different analyses of interactions between science and society, in the social and political contexts with publics and politics that show where and how we could improve. The opening up of science and academia in matters of problem choice, data sharing and evaluation of research together with stakeholders from outside academia will help to increase the impact of science on society. It ideally should promote equality, inclusion and diversity of the research agendas. This, I will argue requires an Open Society with Deweyan democracy and safe spaces for deliberations where a diversity of publics and their problems can be heard. In this transition we have to pay close and continuous attention to the many effects of power executed by agents in society and science that we know can distort these ‘ideal deliberations’ and undermine the ethics of these communications and possibly threaten the autonomy and freedom of research.
Transition to Open Science
Authors: Miedema Frank 
Published: October 2021

AbstractMany initiatives addressing different types of problems of the practice of science and research have been described or cited in this book. Some were one-issue local actions, some took a broader approach at the national and some at EU level. Some stayed on, others faded after a few years. Many of the issues addressed by these movements and initiatives were part of the system of science and appeared to be systemically interdependent. This is how they converged and precipitated in the movement of Open Science, somewhere at the beginning of the second decade of this century. I discuss the major move that was made since 2015 in the EU to embrace the Open Science practice as the way science and research are being done in Europe. This elicited tensions at first foremost relate to uncertainty regarding scholarly publishing, of how and where we publish open access. But also, with respect to what immediate sharing of data and results in daily practice of researchers means, how we value and give credit for papers and published data sets. It thus poses the question of how, if at all, we must compare incomparable academic work, how we get credit and build reputations in this new open practice of science. It is indeed believed that Open Science with its practice of responsible science will be a major contribution to address the dominant problems in science that we have analysed thus far, or at least will help to mitigate them. Open Science holds a promise to take science to the next phase as outlined in the previous chapters. That is not a romantic naive longing for the science that once was. It will be a truly novel way, but realistic way of doing scientific inquiry according to the pragmatic narrative pointed out.The Transition to Open Science as can be anticipated from the analyses above will not be trivial. The recent discussions have already shown that the transition to Open Science, even between EU member states, is a very different thing because of specific national, societal and academic contexts.I will conclude this chapter reporting some of my first-hand experiences, in Brussels and during visits to several EU member states in the course of a Mutual Learning Exercise, but also encounters in North America, South East Asia and South Africa where we in the past years have discussed Open Science. Although we know science and scholarship have many forms and flavours and that wherever you go, there is not one scientific community. For me discussing the Transition to Open Science in the past four years was really a Learning Exercise, an amazing, mostly encouraging, but many times quite shocking, even saddening adventure.
Modular symmetry at level 6 and a new route towards finite modular groups
Authors: Li Cai-Chang , Liu Xiang-Gan , Ding Gui-Jun 
Published: October 2021

Abstract
We propose to construct the finite modular groups from the quotient of two principal congruence subgroups as Γ(N′)/Γ(N″), and the modular group SL(2, ℤ) is ex- tended to a principal congruence subgroup Γ(N′). The original modular invariant theory is reproduced when N′ = 1. We perform a comprehensive study of $$ {\Gamma}_6^{\prime } $$

Γ
6
′

modular symmetry corresponding to N′ = 1 and N″ = 6, five types of models for lepton masses and mixing with $$ {\Gamma}_6^{\prime } $$

Γ
6
′

modular symmetry are discussed and some example models are studied numerically. The case of N′ = 2 and N″ = 6 is considered, the finite modular group is Γ(2)/Γ(6) ≅ T′, and a benchmark model is constructed.
Non-vernalization requirement in Chinese kale caused by loss of BoFLC and low expressions of its paralogs
Authors: Tang Qiwei , Kuang Hanhui , Yu Changchun , An Guanghui , Tao Rong , Zhang Weiyi , Jia Yue 
Published: October 2021

Abstract
Key message
We identified the loss ofBoFLC gene as the cause of non-vernalization requirement inB. oleracea. Our developed codominant marker ofBoFLCgene can be used for breeding program ofB. oleraceacrops.

Abstract
Many species of the Brassicaceae family, including some Brassica crops, require vernalization to avoid pre-winter flowering. Vernalization is an unfavorable trait for Chinese kale (Brassica oleracea var. chinensis Lei), a stem vegetable, and therefore it has been lost during its domestication/breeding process. To reveal the genetics of vernalization variation, we constructed an F2 population through crossing a Chinese kale (a non-vernalization crop) with a kale (a vernalization crop). Using bulked segregant analysis (BSA) and RNA-seq, we identified one major quantitative trait locus (QTL) controlling vernalization and fine-mapped it to a region spanning 80 kb. Synteny analysis and PCR-based sequencing results revealed that compared to that of the kale parent, the candidate region of the Chinese kale parent lost a 9,325-bp fragment containing FLC homolog (BoFLC). In addition to the BoFLC gene, there are four other FLC homologs in the genome of B. oleracea, including Bo3g005470, Bo3g024250, Bo9g173370, and Bo9g173400. The qPCR analysis showed that the BoFLC had the highest expression among the five members of the FLC family. Considering the low expression levels of the four paralogs of BoFLC, we speculate that its paralogs cannot compensate the function of the lost BoFLC, therefore the presence/absence (PA) polymorphism of BoFLC determines the vernalization variation. Based on the PA polymorphism of BoFLC, we designed a codominant marker for the vernalization trait, which can be used for breeding programs of B. oleracea crops.
Spatial perspective-taking: insights from sensory impairments
Authors: Job Xavier E. , Kirsch Louise P. , Auvray Malika 
Published: October 2021

AbstractInformation can be perceived from a multiplicity of spatial perspectives, which is central to effectively understanding and interacting with our environment and other people. Sensory impairments such as blindness are known to impact spatial representations and perspective-taking is often thought of as a visual process. However, disturbed functioning of other sensory systems (e.g., vestibular, proprioceptive and auditory) can also influence spatial perspective-taking. These lines of research remain largely separate, yet together they may shed new light on the role that each sensory modality plays in this core cognitive ability. The findings to date reveal that spatial cognitive processes may be differently affected by various types of sensory loss. The visual system may be crucial for the development of efficient allocentric (object-to-object) representation; however, the role of vision in adopting another’s spatial perspective remains unclear. On the other hand, the vestibular and the proprioceptive systems likely play an important role in anchoring the perceived self to the physical body, thus facilitating imagined self-rotations required to adopt another’s spatial perspective. Findings regarding the influence of disturbed auditory functioning on perspective-taking are so far inconclusive and thus await further data. This review highlights that spatial perspective-taking is a highly plastic cognitive ability, as the brain is often able to compensate in the face of different sensory loss.
Repeated percutaneous hepatic perfusion with melphalan can maintain long-term response in patients with liver cancers
Authors: Veelken Rhea , Maiwald Bettina , Strocka Steffen , Petersen Tim-Ole , Moche Michael , Ebel Sebastian , Denecke Timm , Rehak Matus , Struck Manuel Florian , Forstmeyer Dirk , Rademacher Sebastian , Seehofer Daniel , Berg Thomas , van Bömmel Florian 
Published: October 2021

AbstractChemosaturation (CS; CHEMOSAT®, Delcath Systems Inc.) temporarily administers melphalan into the liver by percutaneous hepatic perfusion (PHP). CS-PHP can effectively control growth in liver tumors, but efficacy and tolerability of sequential treatments are unclear. We analyzed outcomes of sequential CS-PHP treatment. Patients with either unresectable intrahepatic metastases of ocular melanoma (OM, n = 9), cholangiocarcinoma (CCA, n = 3), or hepatocellular carcinoma (HCC, n = 1) were recruited retrospectively. Response was assessed by tomography imaging. Ten patients (mean age 60 years) with more than one CS-PHP treatment were included. CS-PHP was administered 2–6 times in the OM patients, 3 times in the CCA, and the HCC patient received 6 treatments. Overall response rate (ORR) to CS-PHP was 80%, and stable disease was achieved in one patient. Median hepatic progression-free survival (hPFS) was 336 days (range 0–354) for OM, 251 days for the CCA patient, and 256 days for the HCC patient. At the end of observation (153–701 days after first CS-PHP), 6/10 patients were still alive (5/9 with OM, 0 with CCA, and 1 with HCC). Death cases were not related to CS-PHP. Adverse events were mostly hematologic, grade I-IV, and self-resolving. The liver function was not deteriorated by CS-PHP. We conclude that repeated CS-PHP treatments were effective and well tolerated in the long term.
The limiting factors and regulatory processes that control the environmental responses of C3, C3–C4 intermediate, and C4 photosynthesis
Authors: Johnson Jennifer E. , Field Christopher B. , Berry Joseph A. 
Published: October 2021

AbstractHere, we describe a model of C3, C3–C4 intermediate, and C4 photosynthesis that is designed to facilitate quantitative analysis of physiological measurements. The model relates the factors limiting electron transport and carbon metabolism, the regulatory processes that coordinate these metabolic domains, and the responses to light, carbon dioxide, and temperature. It has three unique features. First, mechanistic expressions describe how the cytochrome b6f complex controls electron transport in mesophyll and bundle sheath chloroplasts. Second, the coupling between the mesophyll and bundle sheath expressions represents how feedback regulation of Cyt b6f coordinates electron transport and carbon metabolism. Third, the temperature sensitivity of Cyt b6f is differentiated from that of the coupling between NADPH, Fd, and ATP production. Using this model, we present simulations demonstrating that the light dependence of the carbon dioxide compensation point in C3–C4 leaves can be explained by co-occurrence of light saturation in the mesophyll and light limitation in the bundle sheath. We also present inversions demonstrating that population-level variation in the carbon dioxide compensation point in a Type I C3–C4 plant, Flaveriachloraefolia, can be explained by variable allocation of photosynthetic capacity to the bundle sheath. These results suggest that Type I C3–C4 intermediate plants adjust pigment and protein distributions to optimize the glycine shuttle under different light and temperature regimes, and that the malate and aspartate shuttles may have originally functioned to smooth out the energy supply and demand associated with the glycine shuttle. This model has a wide range of potential applications to physiological, ecological, and evolutionary questions.
Trait-based responses to cessation of nutrient enrichment in a tundra plant community
Authors: Werner Chhaya M. , Tuomi Maria , Eskelinen Anu 
Published: October 2021

AbstractPlant communities worldwide show varied responses to nutrient enrichment—including shifts in species identity, decreased diversity, and changes in functional trait composition—but the factors determining community recovery after the cessation of nutrient addition remain uncertain. We manipulated nutrient levels in a tundra community for 6 years of nutrient addition followed by 8 years of recovery. We examined how community recovery was mediated by traits related to plant resource-use strategy and plant ability to modify their environment. Overall, we observed persistent effects of fertilization on plant communities. We found that plants with fast-growing traits, including higher specific leaf area, taller stature and lower foliar C:N, were more likely to show a persistent increase in fertilized plots than control plots, maintaining significantly higher cover in fertilized plots 8 years after cessation of fertilization. Additionally, although graminoids responded most strongly to the initial fertilization treatment, forb species were more vulnerable to fertilization effects in the long-term, showing persistent decline and no recovery in 8 years. Finally, these persistent fertilization effects were accompanied by modified environmental conditions, including persistent increases in litter depth and soil phosphorous and lower soil C:N. Our results demonstrate the potential for lasting effects of nutrient enrichment in nutrient-limited systems and identify species traits related to rapid growth and nutrient-use efficiency as the main predictors of the persistence of nutrient enrichment effects. These findings highlight the usefulness of trait-based approach for understanding the persistent feedbacks of nutrient enrichment, plant dynamics, and niche construction via litter and nutrient build-up.
Systemische Entzündung, „Sickness Behavior“ und Erwartungsprozesse
Authors: Schmidt Justine , Reinold Johanna , Klinger Regine , Benson Sven 
Published: October 2021

Zusammenfassung
Hintergrund
Systemische Entzündungsprozesse gehen mit unspezifischen körperlichen und psychischen Krankheitssymptomen einher, darunter Schmerz und affektbezogene Symptome. Diese immunvermittelten Symptome („Sickness Behavior“) beruhen auf der zentralnervösen Wirkung von Immunbotenstoffen wie proinflammatorischen Zytokinen und vermitteln bei akuten Entzündungsreaktionen, etwa nach einer Impfung oder Verletzung, ein adaptives Schonverhalten. Bei chronischen Entzündungsprozessen können die Symptome des Sickness Behavior jedoch zu Einschränkungen der Lebensqualität führen und zur Komorbidität bei chronischen Schmerzerkrankungen beitragen. Trotz der hohen klinischen Relevanz des Sickness Behavior wurden bisher psychologische Ansätze zur Modulation der immunvermittelten Sickness-Symptome kaum untersucht. Einen Ansatz könnte die Nutzung von Erwartungseffekten bieten, da positive und negative Erwartungen (Placebo- bzw. Nocebo-Effekte) nachweislich einen Einfluss auf Schmerz und affektbezogene Symptome haben.

Ziel der Arbeit
In dieser Übersichtsarbeit werden die immunologischen und psychobiologischen Faktoren, die zu Schmerz im Kontext des Sickness Behavior beitragen, zusammengefasst. Aufbauend wird diskutiert, wie durch positive und negative Erwartungen Sickness-Symptome beeinflusst werden können und welche biologischen und psychologischen Mechanismen dabei involviert sind. Ziel ist es, potenzielle Ansatzpunkte zur Optimierung von Erwartungen im Kontext immunvermittelter Sickness-Symptome zu identifizieren. Perspektivisch lassen sich darauf aufbauend Interventionen entwickeln, um diese Symptome zu reduzieren sowie die Wirkungen und Nebenwirkungen von immunassoziierten Therapien durch gezielte Erwartungsinduktionen im Rahmen der Kommunikation mit Patient:innen positiv zu beeinflussen.
Measurement of tear resistance after manual capsulorhexis and femtosecond laser–assisted capsulotomy of crystalline lenses
Authors: Patzlaff-Günther Mandy , Fromm Michael , Kern Thomas , Bartram Martin , Schwäblein Anna , Heinemann Dag , Johannsmeier Sonja , Framme Carsten , Ripken Tammo 
Published: October 2021

Abstract
Background
In this study, the tear resistance of porcine lens capsules after continuous curvilinear capsulorhexis (CCC) and femtosecond (fs)-laser-assisted capsulotomy for cataract surgery (FLC) with different laser parameters is measured with a custom-made testing setup.

Methods
Forty-five fresh porcine lenses were randomly chosen for CCC (n = 15) or FLC 1 (n = 15) and FLC 2 (n = 15). The FLC 1-group was treated with smaller spot distances than the FLC 2-group. The force necessary to break the opening of the anterior capsule and the maximum displacement were measured.

Results
The mean tear resistance of the CCC-group (150 ± 70 mN) was higher than that of the FLC 1-group (60 ± 20 mN) and the FLC 2-group (30 ± 20 mN).

Conclusion
It could be shown that CCC leads to a significantly higher tear resistance of the opening than FLC in porcine lenses. The femtosecond laser group demonstrated that smaller spot distances lead to a higher tear resistance.
Humanizing Pedophilia as Stigma Reduction: A Large-Scale Intervention Study
Authors: Harper Craig A. , Lievesley Rebecca , Blagden Nicholas J. , Hocken Kerensa 
Published: October 2021

AbstractThe stigmatization of people with pedophilic sexual interests is a topic of growing academic and professional consideration, owing to its potential role in moderating pedophiles’ emotional well-being, and motivation and engagement in child abuse prevention schemes. Thus, improving attitudes and reducing stigmatization toward this group is of paramount importance. Prior research has suggested that narrative humanization—presenting personal stories of self-identified non-offending pedophiles—could be one route to doing this. However, this work has only been conducted with students or trainee psychotherapists, meaning the public generalizability of this method is still unknown. In this study, we compared two stigma interventions to test whether narratives reduce stigma toward people with pedophilic interests more effectively than an informative alternative (scientific information about pedophilia). Using a longitudinal experimental design with a lack of non-intervention control (initial N = 950; final N = 539), we found that narratives had consistently positive effects on all measured aspects of stigmatization (dangerousness, intentionality), whereas an informative alternative had mixed results, and actually increased perceptions of pedophiles’ levels of deviance. These effects were still present four months after the initial presentation. We discuss these data in relation to ongoing debates about treating pedophilia as a public health issue requiring a broad societal approach to well-being and child abuse prevention.