bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of imperfections in the buckling resistance of steel beam-columns under fire
Authors: Nemer Samer , Papp Ferenc 
Published: April 2021

AbstractThis paper presents an investigation on the influence of structural imperfections on the ultimate load capacity of steel welded beam-columns with class 4 cross-section under elevated temperatures. This is done by considering different amplitudes for the global and local (plate) imperfections, and different residual stresses distributions available in the literature. To this purpose, a geometrically and materially non-linear finite element model using Abaqus software has been used to determine the buckling resistance of a steel welded beam-column at elevated temperatures, using the material properties of EN1993-1-2. The imperfection sensitivity of beam-columns is reported: the influences of the amplitudes of the geometric imperfection and the patterns of the residual stress on the load capacity are compared.
Modeling of stress-strain relation of cement-treated sand under compression
Authors: Tariq Khawaja Adeel , Maki Takeshi 
Published: April 2021

Abstract
This research work has been conducted to model the uniaxial stress-strain compressive behavior of cement-treated sand and its post-peak softening area. The cylindrical specimens were produced by using limestone powder, sand and high early strength cement. The mixtures were made by using different ratios of water to cement with fixed ratio of limestone powder to cement and cement to sand. The stress-strain behavior in post-peak zone of cement-treated is adjusted with introduction of compression softening factor. Uniaxial compressive stress-strain relationships after amending the Japanese Society of Civil Engineers model are proposed. Finite element analysis shows that the suggested model estimates well the compressive behavior of cement-treated sand.
Ser-322 Is a Critical Site for PKC Regulation of the MDCKCell Taurine Transporter (pNCT)
Authors: HAN XIAOBIN , BUDREAU ANDREA M. , CHESNEY RUSSELL W. 
Published: April 2021

Abstract.
Previous studies have shown that the Madin—Darby canine kidney cell taurine transporter (pNCT) is downregulated by protein kinase C (PKC) activation. In this study, it is hypothesized that the highly conserved serine-322 (Ser-322) located in the fourth intracellular segment (S4) may play an important role in the function of taurine transporter, which is modulated by PKC phosphorylation. It is demonstrated that Ser-322 is the critical site of PKC phosphorylation, as determined by site-directed mutagenesis. When Ser-322 of pNCT was changed to alanine (S322A) and this mutant was evaluated in an oocyte expression system, taurine transport activity increased threefold compared with control (wild-type pNCT). Activation of PKC by the active phorbol ester 12-myristate 13-acetate did not influence taurine transport by mutant S322A. Kinetic analysis showed that the mutation of Ser-322 essentially changed the V
max, rather than the K
m, of the transporter. Mutation of all other PKC consensus sites did not affect transporter activity when expressed in the oocyte system. Western blot analysis showed that expression of taurine transporter protein was similar in oocytes injected with either wild-type or mutant pNCT cRNA, indicating that the enhanced taurine transport activity by mutant S322A was not caused by a greater amount of transporter expressed in the oocyte. Furthermore, this study demonstrated that the taurine transporter was phosphorylated after PKC activation, and this effect was not observed in mutant S322A. In conclusion, Ser-322 is critical in PKC regulation of taurine transporter activity. The steady-state taurine transporter activity is tightly controlled by endogenous PKC phosphorylation of Ser-322, which is located in the fourth intracellular segment of the taurine transporter.
Focal Segmental Glomerulosclerosis
Authors: SCHWARTZ MELVIN M. , EVANS JONI , BAIN RAY , KORBET STEPHEN M. 
Published: April 2021

Abstract.
The cellular lesion (CELL), seen in some patients with primary focal segmental glomerulosclerosis (FSGS), comprises proliferation, hypertrophy, and pathologic changes in the cells overlying the glomerular scar. The prognosis of the cellular lesion was retrospectively studied in 100 patients with FSGS (43 had FSGS-CELL and 57 had FSGS without the cellular lesion (classic segmental scar [CS]). Patients with the FSGS-CELL lesion were more often black and severely proteinuric and developed more end-stage renal disease (ESRD). Nephrotic patients with FSGS-CELL (n = 39) were more proteinuric at presentation than patients with FSGS-CS (n = 36). ESRD developed more frequently in patients with the FSGS-CELL (17 of 39, 44% versus 5 of 36, 14%, P = 0.005), and patients with extensive FSGS-CELL (≥ 20% glomeruli) were mainly black (94%), severely nephrotic (67%, >10 g/d), and had a poor response to treatment (23% remission). In nephrotic patients, initial serum creatinine, interstitial expansion ≥20%, and CELL independently predicted ESRD. However, the rates of remission in treated nephrotic patients with FSGS-CELL and FSGS-CS were the same (9 of 17, 53% versus 17 of 39, 52%), and patients in both groups who achieved a remission had a 5-yr survival of 100%. Steroid treatment was the only variable that predicted remission. Patients with the FSGS-CELL have an increased prevalence of ESRD, but the improved prognosis associated with remission is so significant that a therapeutic trial is warranted in all nephrotic FSGS patients, regardless of the presence of the cellular lesion.
Transduction of Renal Cells in Vitro and in Vivo by Adeno-Associated Virus Gene Therapy Vectors
Authors: LIPKOWITZ MICHAEL S. , HANSS BASIL , TULCHIN NATALIE , WILSON PATRICIA D. , LANGER JESSICA C. , ROSS MICHAEL D. , KURTZMAN GARY J. , KLOTMAN PAUL E. , KLOTMAN MARY E. 
Published: April 2021

Abstract.
There has been an increasing interest recently in the possibility of treating renal diseases using gene therapy. The ability to pursue gene therapy for renal diseases has been limited by the availability of an adequate system for gene delivery to the kidney. Adeno-associated virus (AAV) is a defective virus of the parvovirus family that has a number of properties attractive for renal gene delivery: recombinant AAV contains no viral genes; expression of genes delivered by these vectors does not activate cell-mediated immunity; the virus is able to transduce nondividing as well as dividing cells; and both wild-type and recombinant AAV integrate into the host chromosome resulting in long-term gene expression. Studies were performed to determine whether AAV can deliver reporter genes to kidney cells in vitro and in vivo. These studies show that AAV can deliver reporter genes with approximately equal efficiency to human mesangial, proximal tubule, thick ascending limb, collecting tubule, and renal cell carcinoma cells in primary culture. Immortalized mouse mesangial cells are transduced at a much greater efficiency. Transduction can be enhanced by pharmaceutical agents up to sevenfold in primary cells (transducing up to 20% of primary cells per well) and as much as 400-fold in immortalized mesangial cells. AAV delivered in vivo by intraparenchymal injection results in at least 3 mo of reporter gene expression in tubular epithelial, but not glomerular or vascular, cells at the injection site. These data indicate that AAV can deliver genes to renal cells both in vitro and in vivo resulting in prolonged gene expression, and thus AAV can be a useful tool for renal gene delivery.
The Angiotensin-Converting Enzyme Genotype and Microalbuminuria in Autosomal Dominant Polycystic Kidney Disease
Authors: VAN DIJK MARJAN A. , PETERS DORIEN J.M. , BREUNING MARTIJN H. , CHANG PETER C. 
Published: April 2021

Abstract.
Autosomal dominant polycystic kidney disease (ADPKD) has a variable clinical course. Clinical parameters associated with a worse prognosis are hypertension and proteinuria or microalbuminuria (MA). Because chronic stimulation of the renin-angiotensin system is likely to be present in ADPKD patients, the effect of the angiotensin-converting enzyme insertion/deletion (ACE I/D) genotype on the variability of these clinical parameters was examined in untreated ADPKD patients. Proteinuria and MA were determined in 24-h urine collections. BP measurements were performed with an ambulatory monitor, over 24 h. With analysis of covariance, the ACE genotype was found to be significantly associated with MA, corrected for age, gender, GFR, mean arterial pressure, body surface area, and urinary Na+ excretion (P < 0.05). The patients homozygous for the deletion (DD) had the highest rate of MA (P < 0.05) compared to the patients homozygous for the insertion (II). There was no relationship between the ACE genotype and BP or renal function. A significant positive correlation was found between MA and mean arterial pressure (r = 0.31, P < 0.05), whereas a significant negative correlation was found between MA and renal function (r = -0.28, P < 0.05). In conclusion, in ADPKD patients, MA is partly determined by the ACE I/D polymorphism. Because MA is associated with an enhanced progression toward renal failure, the ACE genotype could help in identifying patients at risk for a worse prognosis.
Mycophenolate Mofetil Does Not Modify the Incidence of Cytomegalovirus (CMV) Disease after Kidney Transplantation but Prevents CMV-Induced Chronic Graft Dysfunction
Authors: GIRAL MAGALI , NGUYEN JEAN MICHEL , DAGUIN PASCAL , HOURMANT MARYVONNE , CANTAROVICH DIEGO , DANTAL JACQUES , BLANCHO GILLES , JOSIEN REGIS , ANCELET DARIA , SOULILLOU JEAN PAUL 
Published: April 2021

Abstract.
Ganciclovir, which is used to treat cytomegalovirus (CMV) infection, has been shown in rodent models to abolish CMV-mediated chronic cellular damage and endothelial cell proliferation; when associated with mycophenolate mofetil (MMF), it has been shown to increase its anti—herpes virus activity. This study tested the hypothesis that kidney graft recipients who received antirejection prophylaxis with MMF and who were treated with ganciclovir for a declared CMV disease could be protected from chronic graft dysfunction. Investigated was the impact of ganciclovir-treated CMV diseases in consecutive first kidney recipients according to their immunosuppressive therapy. The azathioprine (Aza)-treated group (Aza group) included 319 patients. The MMF-treated group (MMF group) included 126 patients. CMV disease was clinically defined and confirmed by virological proof of CMV infection and was treated for at least 14 d with ganciclovir. Despite having the same incidence (21.6% in the Aza group versus 24.6% in the MMF group) and severity, CMV disease was significantly associated with graft loss independent of acute rejection episodes or other factors when tested in a Cox proportional model in the Aza group only (P < 10-4). It was shown for the first time that patients whose CMV disease is treated with ganciclovir while they are on MMF therapy are protected from the long-term deleterious consequences of CMV disease on graft survival, independent of acute rejection. It is suggested that the enhanced anti—herpes virus activity of ganciclovir by MMF could contribute to this reported effect, which may represent a significant contribution of MMF efficacy to graft survival.
Two pedestal Tables by Jean-Charles-François Leloy in the Royal Collections of Patrimonio Nacional
Authors: Mateos Martín Mario 
Published: April 2021

The aim of this paper is to provide an in-depth information of two pedestal tables (named Table du Sacre and Guéridon Mauresque) designed by Leloy, and kept in the royal collections of Patrimonio Nacional (National Heritage).
Despite their differences, they both have some elements in common: not only Sèvres porcelain was used as their main decorative material offering painted historical scenes, but also both of them were gifts from French sovereigns to Spanish monarchs. The two pieces were also displayed in the 19th century at the Louvre Royale Manufactures Exhibitions as an example of the high quality that the Sèvres Manufacture achived.
Although the Table du Sacre (table of coronation due to its iconography) is of great interest, the decoration of the Guéridon Mauresque is specially remarkable as it provides an interesting insight between courts. It depicts Boabdil leaving the Alhambra, being directly inspired by the Nasrid Palace (15th century): a piece of furniture depicting a scene of the Spanish Moorish past, was made in France and later offered as a gift to the regent of the Spanish Kingdom María Cristina de Borbón.
Una lectura de Rayuela desde el Fantasma de la Maga = A Reading of Rayuela from Maga’s Ghost
Authors: Plaza Morales Natalia 
Published: April 2021

En el presente trabajo llevamos a cabo una lectura de Rayuela, con el propósito de profundizar en aquellosaspectos de estilo que nos resultan pertinentes en cuanto a la relación que mana entre los personajes de Horacio Oliveira y de La Maga en esta novela. En este sentido, pretendemos elucidar la caracterización de estos dos personajes por medio de la neutralidad como modo de lectura para comprender el juego narrativo cortazariano y reforzar la idea de una búsqueda de ruptura dicotómica en la narrativa del escritor argentino. El vínculo de Oliveira con las mujeres nos llevará a la lectura del goce como estadoperseguido por el personaje.In the present work we carry out a reading of Rayuela, with the purpose of deepening into those aspects of style which are relevant to us with respect to the relationship that springs between the characters of Horacio Oliveira and La Maga. In this sense, we intend to elucidate the portrayal of these two characters through neutrality as a reading hypothesis, in order to understand the narrative of Cortázar and reinforce the idea of a search for a dichotomous rupture in the narrative of the Argentine writer. Oliveira’s bond with women will lead us to the reading of enjoyment as a state pursued by the character.
Olivante de Laura y la reflexión sobre el vestido = Reflections upon clothing in Olivante de Laura
Authors: Pastrana Santamarta Tomasa Pilar 
Published: April 2021

Antonio de Torquemada nos ofrece en su obra Olivante de Laura las alusiones a prendas propias de los libros de caballerías; sin embargo, aporta una novedad frente a otras de su género pues la trama cuestiona la validez del vestido como elemento marcador de jerarquía. La noción medieval de «cada uno según su estado» se convierte así en objeto de debate por parte de los propios personajes. El héroe viste con ropas no acordes con su estatus para poder acercarse a su amada, al igual que hacían las gentes dela época para poder conseguir sus fines. A partir de este hecho, Torquemada muestra sutilmente los cambios que la sociedad está sufriendo y cómo se hace necesario establecer en vez del vestido, otro elemento más eficaz que pueda representar las jerarquías sociales, como pudiera ser el linaje o la sangre.Antonio de Torquemada displays in Olivante de Laura the typical references to clothing and textiles used in other chivalric books. However, he innovates as he questions the capacity for dress to convey hierarchy. The medieval notion of dressing «according to one´s status» becomes now the central topic for debate about which the main characters discuss. Following the Renaissance trend, the hero disguiseshimself as a shepherd in order to approach his loved one. His behavior is a reflection of the times, when people also wear clothes not appropriate to their status. It is from here that Torquemada subtly shows the way society is changing and claims for a new and more effective method to determine and measure hierarchy. Clothing will no longer be valid, he then proposes linage.
JUAN ANTONIO GALLARDO, Después del invierno (Cuadernos), Sevilla, Ediciones En huida, 2018, 181 pp.
Authors: Balcells José María 
Published: April 2021

Reseña de JUAN ANTONIO GALLARDO, Después del invierno (Cuadernos), Sevilla, EdicionesEn huida, 2018, 181 pp.
ANTONIO CHAS AGUIÓN (ed.), Escritura y reescrituras en el entorno literario del «Cancionero de Baena», Berlín, Peter Lang, 2018, 252 pp.
Authors: Trincado Sabín María Cristina 
Published: April 2021

Reseña de ANTONIO CHAS AGUIÓN (ed.), Escritura y reescrituras en el entorno literariodel «Cancionero de Baena», Berlín, Peter Lang, 2018, 252 pp.
Teresa de Ávila y la poesía cancioneril = Teresa de Ávila and the songbook poetry
Authors: López de Castro Armando 
Published: April 2021

Teresa de Jesús escribió poesía porque tenía un alma musical y sabía dar ritmo a sus poemas. Es una música que surge de la oscuridad y habla de lo profundo, destinada a elevarse desde la fuerza de su dolorosa espera, de ahí que invite a la plegaria con el estremecimiento de ser sustancia viva. Vueltos hacia su propio interior, sus poemas potencian su energía sonora desde la desnudez de su fingida retórica y nos hacen volar el oído hacia lo sobrenatural, buscando la recuperación del orden perdido. Teresa de Jesús wroter poetry because she had a musical soul and knew how to give rhythm to her poems. It is a music that emerges from the darkness and speaks from the deep, destined to rise from the force of its painful waiting, hence the invitation to prayer with the shudder of being living substance. Turned towards his own interior, his poems enhance his sound energy from the nakedness of his feigned rhetoric and make us blow our ears towards the supernatural, seeking the recovery of the lost order.
Final year medical students versus interns: information seeking behaviour about COVID-19 therapy in India
Authors: David Rosme , George Deepthi Mary , Chandra Shalini , Marwaha Vishal , Palatty Princy Louis 
Published: April 2021

Background: Doctors alone must be capable of taking ultimate responsibilities for making decisions in clinical uncertainties. A right clinical judgement and management was the ultimate priority for health care workers during the COVID-19 pandemic. The objective of our study was to access knowledge about COVID-19 treatment among the final year bachelor of medicine and bachelor of surgery (MBBS) students and interns and thereby to understand the information seeking behaviour.Methods: Multicentric cross-sectional questionnaire-based study among the final year MBBS students and interns. The google form questionnaire was sent to the participants through whatsapp or mail. The questions were related to the drugs, the precautionary measures and the dead body disposal in COVID-19. Attitude regarding seeking information about the new disease, updated treatment guidelines as well as the preferred resource materials was also studied. The sample size was calculated based on a pilot study.Results: Out of 316 participants, 30.7% had good, 53.2% had adequate and 16.1% had inadequate knowledge regarding the updated treatment guidelines. In one of the questions about hydroxychloroquine, 51.5% final year MBBS students (n=200) and 63.8% interns (n=116) responded correctly (p<0.034). 65.4% gathered information by self-directed learning through various sources. 45.8% gathered information from social media while 44.4% read printed materials and 39.3% heard online/offline lectures.Conclusions: We conclude that the final year MBBS students and interns have satisfactory knowledge about COVID-19 treatment. Interns had better awareness than the final year MBBS students. Retaining the theoretical knowledge during internship will make the young doctors more confident while practicing.
Microbiological profile and antibiotic resistance pattern of urinary tract infection in a tertiary care hospital
Authors: R. Vismaya V. , Shajihan Naiema , Ramesh Midhun , Devi Ambika 
Published: April 2021

Urinary tract infection (UTI), of varying severity is one of the most commonly encountered ailments in nephrology outpatient department (OPD). The commonest pathogens causing community acquired UTI (CAUTI) are E. Coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia. There is a rapidly rising trend of antibiotic resistance among these uropathogens, may be due to indiscriminate antibiotic usage and poor patient compliance. We conducted a retrospective analysis of all culture proven UTI cases that attended the nephrology OPD of S. K. hospital, Trivandrum from August 2017 to July 2019 (24 months). 130 males and 121 females were included in the study. The mean age of the study group was 62.8 years with a male predominance in the age group above 50 years and a female predisposition in less than 50 years group. Commonest pathogen isolated in urine culture was E. coli (52.98%) followed by Klebsiella (39.09%), Citrobacter (8.76%), Pseudomonas (8.37%), Enterobacter (2.39%), Enterococci (1.99%), Candida (1.59%), Acinetobacter (1.2%), Proteus (1.2%), Streptococci (1.2%) and Serratia (0.4%).
Assessment of functional outcome of operative vs conservative management of displaced clavicle fractures
Authors: Singh Harpreet , Saoji Krushna , Tyagi Sangam , Patel Dhruv , Patel Parth , Patel Tilak 
Published: April 2021

<p><strong>Background: </strong>clavicle fractures account for approximately 2.6% of all fractures. Middle third fractures account for 80% of all clavicle fractures. Historically, clavicle fractures have been treated mostly nonoperatively with clavicular brace, but due to increase rate of complications such as nonunion and malunion, clavicle fractures are now increasingly being treated surgically which results in lower rate of such complications, besides improved patient oriented outcome and early mobilization.</p><p><strong>Methods: </strong>Current study is a prospective and observational comparative study, conducted over 30 patients diagnosed with displaced clavicle fractures coming to the department of orthopaedics in a tertiary care hospital in South Rajashthan between January 2019 to June 2020. Patients were then allotted alternatively into two groups. Patients selected for conservative treatment were treated with the figure of eight clavicle brace and arm sling pouch. Patients selected for operative treatment were treated with plating. Functional outcomes were assessed using Constant and Murley score in every follow up at 3 month and 6 month; and fracture union was assessed by serial radiographs taken at sixth week, third month and sixth month.</p><p><strong>Results: </strong>Among 30 patients, 15 patients were treated conservatively and rest 15 patients were treated surgically with plating. Functional outcome at the end of third and sixth months of follow up were measured by using Constant Murley score and found significantly higher in operative group than conservative group.</p><p><strong>Conclusions:</strong> In our study, it was found that at the end of 6 month follow up, patients treated surgically with plating had better functional outcomes than conservatively treated patients as measured by Constant and Murley score. It was also seen that, the duration of union and the incidence of complications was less in the operative group as compared to the conservative group.</p><p><strong> </strong></p>