bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of gemcitabine and cisplatin versus oral capecitabine alone in metastatic gallbladder cancer
Authors: Kumar Deepak , Rastogi Neeraj , Agarwal Sushma , Mishra Shagun , Kumar Shaleen , Lal Punita , Singh Shalini , Choudhary Sunil 
Published: October 2021

Aims:
There is no consensus for palliative chemotherapy regimen in metastatic gallbladder cancer. We did a retrospective study to compare the treatment outcome in patients of metastatic gallbladder cancer treated with either gemcitabine + cisplatin (regimen A) or oral capecitabine (regimen B) alone.

Subjects and Methods:
A total of 67 patients between January 2015 and September 15 treated with either regimen A or regimen B were retrospectively evaluated. Statistical analysis was done in June 2019. Kaplan–Meir and Log rank test were used to compare survival between two arms.

Results:
Out of 67 patients, 31/67 (46%) received regimen A, and 36/67 (54%) received regimen B. Male to female ratio was 1:3. About 42% patients in regimen A and 20% in regimen B required palliative stenting. Median number of chemotherapy cycles was 4 in both regimen A (range 1->6) and regimen B (range 1->6). Patients receiving 3 cycles and 6 cycles of chemotherapy in regimen A and regimen B was 68% and 31% versus 70% and 63%, respectively (P = 0.86). Response assessment as any response (complete response + partial response + disease was stable) after 3 cycles and 6 cycles was 71% and 57% (P = 0.20), 44% and 39% (P = 0.29), in regimen A and B, respectively. Median survival was 23 weeks (range 2–106 weeks) in regimen A and 15 weeks (range 4–83 weeks) in regimen B (P = 0.40).

Conclusions:
The present study shows gemcitabine and cisplatin has nonsignificant better survival compared to oral capecitabine. However, oral capecitabine is more convenient and easy to administer. Studies with larger sample size are needed to further establish the standard chemotherapy guidelines.
Macular Infarction Following Intravitreal Clindamycin Injection
Authors: Hedayatfar Alireza , Zand Amin , Faghihi Hooshang , Gordiz Arzhang , Abdi Fatemeh 
Published: October 2021

Purpose:
To report a case of Toxoplasma retinochoroiditis that was complicated by macular infarction following intravitreal clindamycin injection.

Methods:
A 32-year-old otherwise healthy woman with the diagnosis of reactivation of Toxoplasma retinochoroiditis in her right eye, underwent intravitreal clindamycin injection. Shortly after injection, the visual acuity deteriorated, and the fundus examination revealed an extensive area of macular necrosis accompanied by vascular occlusion.

Results:
The patient was observed. Unfortunately, the condition did not improve over time and resulted in a large area of retinal atrophy.

Conclusion:
Macular infarction should be considered a rare but disastrous complication that can result in severe, irreversible visual loss.
The Effect of Meibomian Gland Dysfunction Treatment on Sleep Quality
Authors: Zarei-Ghanavati Siamak , Hassanzadeh Samira , Khorasani Abbas Azimi , Ehsaei Asieh 
Published: October 2021

Purpose:
To assess the therapeutic efficacy of a combinational therapy, including conventional treatment and intense pulsed light (IPL) technique on sleep quality of patients with meibomian gland dysfunction (MGD).

Methods:
Fifty participants with a clinical diagnosis of MGD were enrolled in this study. Participants underwent three sessions of IPL therapy. There was a 2-week interval between IPL sessions 1 and 2 and 1 month between sessions 2 and 3. Treatment was supplemented with conventional home-based therapy (including lid hygiene, warm compress, eyelid massage, and lid margin scrub) for MGD. Dry eye symptomatology, tear film, and ocular surface parameters were evaluated at baseline (day 0) and days 15, 45, and 75. Sleep quality was assessed before and after the study using Pittsburgh Sleep Quality Index (PSQI).

Results:
PSQI components improved significantly at day 75 in comparison with the baseline (all P < 0.05). Ocular Surface Disease Index (OSDI) score, noninvasive Keratograph tear break-up time (NIKBUT), fluorescein tear break-up time (FTBUT), meibomian gland expressibility, meibum quality score, and tear osmolarity improved at follow-up visits (P < 0.05). Younger patients showed more improvement in NIKBUT, sleep quality, and duration (P = 0.024, P = 0.047, and P = 0.008). Sleep latency decreased with increased NIKBUT and FTBUT and decreased OSDI score (P = 0.001, P = 0.005, and P = 0.041).

Conclusions:
The treatment of MGD is effective for improving sleep quality. Younger patients may preferentially benefit from the treatment.
Descemet's Membrane Endothelial Keratoplasty and Phacoemulsification
Authors: Mahmoud Hussien Ahmed Mahmoud Ragab , Elmassry Ahmed , Ghaith Alaa Atef , Badawi Goweida Mohamed Bahgat 
Published: October 2021

Purpose:
To compare the outcomes of Descemet's membrane endothelial keratoplasty (DMEK) combined with phacoemulsification versus DMEK following phacoemulsification.

Methods:
In this interventional retrospective comparative nonrandomized case series study, patients with Fuchs endothelial corneal dystrophy (FECD) with either cataract or previous cataract surgery with intraocular lens (IOL) implantation were assigned to one of the two groups according to lens status. Group 1 included patients who had cataract and FECD and would undergo triple procedure (phacoemulsification with IOL implantation and DMEK), whereas Group 2 included patients who had FECD and had phacoemulsification with IOL implantation earlier and would undergo DMEK only as a sequential procedure.

Results:
Postoperative best corrected visual acuity (BCVA) in both groups at 1 week, 1 month, 3 months, and 6 months revealed a statistically nonsignificant difference between the two groups with mean logMAR BCVA at 6 months of 0.07 ± 0.18 and 0.07 ± 0.19 in Group 1 and Group 2, respectively (P > 0.05). The drop in endothelial cell density by the end of the 6th postoperative month was by 39.44% ±7.92 and 38.73% ±8.10 in the triple-procedure group and DMEK only group, respectively (P = 0.005). Total postoperative complications rate and the rebubbling rate were statistically similar between both groups with 13.5% and 12.5% rebubbling rate in Group 1 and Group 2, respectively (P > 0.05).

Conclusion:
Visual outcomes, endothelial cell loss, and rebubbling rate are comparable when DMEK is combined with phacoemulsification or when it is performed as staged procedure, without statistically significant difference in the outcomes.
Macular Optical Coherence Tomography before Cataract Surgery
Authors: Alizadeh Yousef , Akbari Mitra , Moghadam Reza Soltani , Medghalchi Abdolreza , Dourandeesh Maryam , Bromandpoor Fariborz 
Published: October 2021

Purpose:
To determine the benefits of performing preoperative spectral domain optical coherence tomography (SD-OCT) and to identify occult macular pathologies in patients scheduled for routine cataract surgery.

Methods:
In this cross-sectional study, macular SD-OCT scans were performed on all patients with clinically undetected macular abnormalities who were scheduled for cataract surgery. Patients with clinically evident macular abnormalities were excluded from the study. A retinal specialist reviewed all the scans. The severity of the cataract was determined using the Oxford Clinical Cataract Classification and Grading System.

Results:
Of the 598 evaluated cases, 33 patients (5.52%) had an occult macular abnormality. The most common pathology found in these patients was idiopathic epiretinal membrane, which was detected in 17 eyes (51.52%), followed by vitreomacular traction in nine eyes (27.27%), and dry age-related macular degeneration in four eyes (12.12%). Full-thickness macular holes and a lamellar macular hole were found in two patients (6.06%) and one patient (3.03%), respectively. The frequency of cortical cataracts was significantly lower in patients without macular lesions (P = 0.012) than in those with macular lesions. Multivariate logistic regression analysis revealed that age >70 years (P = 0.025 and odds ratio [OR] =11.12), smoking history (P = 0.043 and OR = 3.43), and hypertension were independently associated with occult macular lesions. The surgical plan was changed for five patients (0.83%).

Conclusions:
Macular SD-OCT can be used to detect occult macular lesions and provide useful information about a macula before cataract surgery. Although preoperative OCT found macular abnormalities in about 5% of patients with presumed normal fundus examination, it can result in changing the surgical plan in 0.83% of all patients.
Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
Authors: Divya Karuppannasamy , Indumathi Chellappan , Vikrant Kanagaraju , Padmanaban Sundaram 
Published: October 2021

Purpose:
To report a case of pseudotumor cerebri (PTC) in a child associated with multisystem inflammatory syndrome in children (MIS-C), associated with presumed coronavirus disease 2019.

Methods:
A previously healthy 11-year-old female child presented with a 4-day history of fever, headache, vomiting, and loose stools. Laboratory investigations revealed neutrophilic leukocytosis, and markers of inflammation (C-reactive protein, ferritin, and interleukin-6) were significantly elevated. Pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by polymerase chain reaction was negative while anti-SARS-CoV-2 antibody was highly reactive. Ophthalmic evaluation for transient visual obscurations during hospital course revealed swelling of the optic disc in both eyes. Spectral-domain optical coherence tomography and ultrasonography confirmed the ophthalmoscopic findings. There was no neurologic deficit. Magnetic resonance imaging of the brain and magnetic resonance venogram revealed no structural lesion. The opening pressure of cerebrospinal fluid (CSF) was 336 mm of water, and CSF composition was normal.

Results:
A diagnosis of PTC associated with MIS-C was made, and the child was treated with oral acetazolamide. Edema of the optic disc regressed following therapy, and the child is under follow-up.

Conclusions:
PTC can occur in association with MIS-C. Clinicians need to be aware of this potential neuro-ophthalmic complication in MIS-C. Prompt diagnosis and treatment can prevent visual loss.
Presentación del dossier: Educación y Lazo Social
Authors: Raquel Gioffredo  
Published: October 2021

La pandemia, en el mundo, desde el año 2020 ha modificado nuestras vidas y por ende a nuestra educación. Al punto tal que temporariamente, no pudimos concurrir a las instituciones educativas de modo presencial. De todos modos, dimos clases como se podía. se fue construyendo un recorrido diferente a través de las aulas virtuales, la radio, los materiales enviados por correos electrónicos, el uso del teléfono (…). Hemos aprendido. Docentes, estudiantes, familias. ¿Qué experiencias nos dejaron? Hoy contamos con nuevos saberes que nos pueden orientar para seguir construyendo caminos.
LA VIRTUALIZACIÓN DEL LAZO SOCIAL EN ESCENARIOS DE CONVERGENCIA TECNOLÓGICA Y SU IMPACTO EDUCATIVO
Authors: Ángel Emilio Riva  
Published: October 2021

El presente artículo surge a partir del desarrollo y validación de un proyecto de investigación posdoctoral de corte transdisciplinario que se interesa en posibles futuros - de futurum: ‘lo que ha de ser’ - para lo humano en escenarios de aceleración del cambio tecnológico. Intenta conferir sentido a las nuevas realidades que desencadenan los procesos de convergencia tecnológica como nuevos existentes apócales intentando comprender, entre otras cuestiones, la reconfiguración del lazo social en los llamados procesos de virtualización, la emergencia de una nueva matriz epocal global y sus impactos en el ámbito de la educación. Cuestiona las ideas ingenuas de coevolución armoniosa y neutral entre lo humano y lo técnico con las que este último pretende mostrarse como lo válido, lo necesario, lo posible, lo inevitable, a través de políticas ontológicas. Políticas que, motorizadas por formas de pensamiento prospectivo estratégico, promovidas desde híbridos organizacionales que responden ideológicamente a posicionamientos tecnocráticos, orquestadas desde centros de poder, están destinadas a generar nuevos compromisos ontológicos a escala global que impactarán en los modos de construcción de lazos sociales a futuro. Avizora en línea generales y prospectivamente la emergencia de nuevos modos de educar y formar, en los cuales contextos y tendencias planetarias son condicionantes de las visiones de expertos y modelos.
Role of tele-rehabilitation in patients following total hip replacement: systematic review of clinical trials
Authors: Samreen Sadiq  , Ashfaq Ahmad  , Ashfaq Ahmed  , Iqra Khan  , Hafiz Muhammad Asim  , Amer Aziz  
Published: October 2021

Objective: Rehabilitation is considered vital aspect of treatment strategy post total hip replacement and results in improvement in functional activities as well as reduction in pain. Telerehabilitation is emerging as alternative to traditional face to face rehabilitation in home care. To explore the current evidence on effectiveness of telerehabilitation as compared to face to face rehabilitation for patients after total hip replacement.
Methodology: A systematic review was conducted. Data bases were searched including Cochrane, Medline, Embase and PEDro from 2000 to latest. A thorough search was performed to retrieve articles missed through databases as well as unpublished grey literature. Methodological quality assessment was performed using Cochrane risk of bias tool and included studies were critically appraised using PEDro scale.
Results: 13 articles finally met the inclusion criteria and were included in the review based on eligibility. However data was not extractable from 1 study due to which 12 studies were finally reviewed. There were 4 Randomized trials, 3 randomized controlled protocols, 3 randomized pilot studies and 1 prospective cohort study. The summary of critical appraisal of included studies through Physiotherapy Evidence Database scale was done which showed that majority of studies had high quality and few studies fall under the category of fair.
Conclusion: Telerehabilitation group reported similar improvement in terms of activities of daily living and quality of life as compared to traditional rehabilitation. This systematic review has established that home based telerehabilitation mode of health care services delivery is an acceptable practical alternative among patients who underwent
Continuous...
Applying Anti Oppressive, Empowerment, and Strengths Based Approaches to Social Work Practice with Hmong Clients
Authors: Lee Serge C , Vang Cindy , Chang Jenny , Vang Pa Der 
Published: October 2021

This conceptual article discusses social work practice with Hmong Americans using a framework that embraces anti-oppressive practice, empowerment and strengths-based approaches. Specifically, the Hmong kinship social construct of kwv tij neej tsa (pronounced: ku tee ning ja) is used to elaborate on the importance of upholding family relationships that transcends the worker-client relationship. Social workers are encouraged to empower Hmong to seek and ask for resources that support their collective value of connection to family and group identity, which is a strength that contributes to resilience and buffers against historically oppressive practices and systems.
PENDAMPINGAN MANAJEMEN USAHA PENINGKATAN GIZI PADA MENU PMT-AS BERBASIS PANGAN LOKAL JANTUNG PISANG DAN IKAN NILA
Authors: Yuyun U Yuyun Triastuti , Rettagung Diana Tri , Eva Salsabila Anwar Annisa 
Published: October 2021

Manajemen usaha peningkatan gizi dengan memanfaatkan jantung pisang dan ikan nila menjadi sempolan dan patty, diharapkan menjadi inovasi baru untuk menu Pemberian Makanan Tambahan Anak Sekolah (PMT-AS). Tujuan penelitian ini: 1) Mengetahui formula yang tepat pada sempolan dan patty; 2) Mengetahui karakteristik sensori sempolan dan patty; 3) Mengetahui daya terima masyarakat pada sempolan dan patty. Metode pada penelitian ini yaitu: penyuluhan dan eksperimen produk dengan formula yang berbeda, pada penggunaan jantung pisang dengan ikan nila, untuk sempolan produk S1 80% : 20%, produk S2 60% : 40%, dan produk S3 40% : 60%. Formula patty untuk produk P1 70% : 30%, produk P2 60% : 40%, sedangkan produk P3 50% : 50%. Hasil penelitian formula yang tepat yaitu produk S2 untuk sempolan, berkarakteristik rasa gurih, tekstur kering dan kenyal, aroma ikan, warna cokelat keabuan. Sedangkan patty pada produk P3, berkarakteristik rasa gurih, tekstur padat dan kenyal, aroma khas jantung pisang dan ikan. Dengan karakteristik tersebut, maka hasil uji hedonik menunjukkan produk S2 untuk sempolan dan P3 untuk patty yang paling disukai pada anak-anak.

Kata kunci: manajemen usaha; peningkatan gizi; jantung pisang; ikan nila; menu PMT-AS.
La ética en la investigación científica de las instituciones de educación superior de República Dominicana
Authors: Peralta Bonifacio Israel , Guzmán Núñez José César 
Published: October 2021

La investigación científica es uno de los ejes principales que constituye la universidad. En este sentido, el objetivo general de esta investigación es analizar la ética de la investigación científica en las instituciones de educación superior de República Dominicana. Para lograr este objetivo, se ha considerado identificar el marco normativo vigente que regula la investigación científica, describir la situación de la investigación científica en las instituciones de educación superior y determinar la relación de la ética con las ciencias particulares en la investigación. Esta investigación es de diseño documental. En el país existe la Ley de Educación Superior Ciencia y Tecnología que rige las investigaciones científicas de las universidades e instituciones y, a su vez un reglamento de investigación, además del Fondo Nacional de Innovación y Desarrollo Científico y Tecnológico (FONDOCYD), aunque la investigación científica de las IES se encuentra comprometida con la poca producción científica en República Dominicana.
INITIATIVES AND ROLE OF WOMEN SCIENTIST FORUMS WITH MENTORSHIP OPPORTUNITIES IN STEM
Authors: Konyeha S. , Agwam G. I. , Musa E. , Ngonadi I. V. , Afehomo A. C. 
Published: October 2021

Women scientists are strategically positioned to drive the current initiatives for achieving targeted sustainable development goals (SDGs). Many women are celebrated today, who have made significant contributions in Science, Technology, Engineering and Mathematics (STEM), despite hurdles they have been faced with in their science careers. Engaging in normal scientific collaborations was difficult for some of them and simply impossible for others. They were not encouraged by the predominantly male environments of university and business worlds, barred from the communities in which male scientists met and conversed, these women in science struggled against discrimination based on gender. While many of these women have been nearly lost to history in a changing world, some achieved such pinnacles as the Nobel Prize by surmounting these hurdles. This paper investigates factors that inhibit women in science. To this end, a survey design based on random sampling technique using a questionnaire instrument was designed, to retrieve information from individuals engaged in science careers. The study population involved one hundred and fourteen post-graduate science students of the University of Benin. Data was collected and analyzed using SPSS 20.0 for descriptive and inferential statistics. The result revealed that females view mentorship as a very important factor towards their career progression in STEM, but 29% lacked mentors. 73% of the women were not aware of women scientist forums with mentorship opportunities. They were faced with the barrier of funding, lack of mentors and personally encountered gender bias amongst other barriers. From our result, it is evident that the role of mentors to mentees and women scientist initiatives alongside forums with mentoring activities, cooperation, networking and collaborative groups is needed to increase the participation of women and girls in STEM. It is recommended that mentoring forums and strategies should be adopted in schools and organizations to encourage girls and women in science.
Policía para la democracia: el caso de Carabineros de Chile
Authors: Abbott Matus Luis Felipe , Villamán Juica Renata , Pino Venegas Paz 
Published: October 2021

La policía es una institución seriamente cuestionada mundialmente por acciones
violentas, discriminatorias y atentatorias de los derechos humanos. Se revisan
antecedentes, iniciativas y recomendaciones insoslayables para la reconfiguración de
una institución esencial para una sociedad democrática cuyo diseño y funcionamiento
debe estar profundamente afianzado en el irrestricto compromiso con la protección de
los derechos humanos.
El museo como instrumento educativo hacía la diversidad: la experiencia del Museo Judío de Chile
Authors: Roitman Deborah 
Published: October 2021

Los museos pueden ser un sistema de comunicación al servicio de la educación y de la promoción cultural. Actúan como educadores en el ámbito de lo no formal, apoyo escolar y vínculo para la educación permanente. Presentamos acá el caso del Museo Interactivo Judío de Chile (MIJ) una institución educativa no formal que a través de sus dos recorridos – Historia judía y Holocausto, otorga capacitación a profesores y desarrolla recursos educativos on line y también presenciales.
Dirigido especial aunque no exclusivamente a público estudiantil, jóvenes entre los 15 y los 18 años, su propósito es mostrar la falacia de los prejuicios y estereotipos que frecuentemente se tienen acerca de los judíos.
El MIJ es un instrumento cuyo objetivo es inculcar y transmitir a su público la importancia que debe asignárseles a los Derechos Humanos, los valores de respeto, diversidad, tolerancia religiosa y la multiculturalidad existentes en toda sociedad. Así, cada uno de estos valores, además del conocimiento adquirido (la educación), intentan prevenir y evitar ideas antisemistas entre la población chilena.
Una perspectiva del mundo del idish y el asociacionismo cultural judío (Tucumán, 1925-1932) Una perspectiva del mundo del idish y el asociacionismo cultural judío
Authors: Teitelbaum Vanesa 
Published: October 2021

A partir de la visita a Tucumán que realizó en 1932 el editor y escritor de origen ruso Zalmen
Reisen (1887-1941), en su papel de delegado del Instituto Científico Judío de Vilna, el propósito de esta pesquisa es avanzar en un campo de estudios poco explorado, referido al universo del idish y la cultura en el asociacionismo judío tucumano de entreguerras. Sin el objetivo de agotar el tema, el artículo examina algunas prácticas de asociación, indaga actividades artísticas - culturales y concluye con una reflexión acerca de las características del asociacionismo judío tucumano entre finales de los años 1920 y comienzos de los ´30.