bluuebunny/crossref_metadata_2025_split huggingface dataset:
A regulatory miRNA–mRNA network is associated with transplantation response in acute kidney injury
Authors: Guo Duan , Fan Yu , Yue Ji-Rong , Lin Tao 
Published: December 2021

Abstract
Background
Acute kidney injury (AKI) is a life-threatening complication characterized by rapid decline in renal function, which frequently occurs after transplantation surgery. However, the molecular mechanism underlying the development of post-transplant (post-Tx) AKI still remains unknown. An increasing number of studies have demonstrated that certain microRNAs (miRNAs) exert crucial functions in AKI. The present study sought to elucidate the molecular mechanisms in post-Tx AKI by constructing a regulatory miRNA–mRNA network.

Results
Based on two datasets (GSE53771 and GSE53769), three key modules, which contained 55 mRNAs, 76 mRNAs, and 151 miRNAs, were identified by performing weighted gene co-expression network analysis (WGCNA). The miRDIP v4.1 was applied to predict the interactions of key module mRNAs and miRNAs, and the miRNA–mRNA pairs with confidence of more than 0.2 were selected to construct a regulatory miRNA–mRNA network by Cytoscape. The miRNA–mRNA network consisted of 82 nodes (48 mRNAs and 34 miRNAs) and 125 edges. Two miRNAs (miR-203a-3p and miR-205-5p) and ERBB4 with higher node degrees compared with other nodes might play a central role in post-Tx AKI. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that this network was mainly involved in kidney-/renal-related functions and PI3K–Akt/HIF-1/Ras/MAPK signaling pathways.

Conclusion
We constructed a regulatory miRNA–mRNA network to provide novel insights into post-Tx AKI development, which might help discover new biomarkers or therapeutic drugs for enhancing the ability for early prediction and intervention and decreasing mortality rate of AKI after transplantation.
Life history strategy and overeating during COVID-19 pandemic: a moderated mediation model of sense of control and coronavirus stress
Authors: Ye Baojuan , Wang Ruining , Liu Mingfan , Wang Xinqiang , Yang Qiang 
Published: December 2021

AbstractBackgroundThis study examined the mediating effect of sense of control and the moderating effect of coronavirus stress on the relationship between life history strategy and overeating among Chinese college students during the COVID-19 period.Methods3310 Chinese students (Mage = 19.74,SD = 1.50; 47% males) completed self-reported questionnaires regarding life history strategy, sense of control, overeating, and coronavirus stress. The data were analyzed using Pearson’s r correlations and moderated mediation analysis.ResultsThe results revealed that control sense mediated the link between life history strategy and college students’ overeating. College students’ coronavirus stress moderated the associations between life history strategy and college students’ sense of control and between control sense and overeating. The association between life history strategy and sense of control was stronger for those with lower coronavirus stress, and the association between sense of control and overeating was stronger for those with lower coronavirus stress.ConclusionsThis study identified that the critical factors were associated with overeating. On the one hand, the research deepens the application and interpretation of life history theory in the field of eating; on the other hand, it provides evidence for the prevention of overeating, and provides theoretical basis for psychological assistance among Chinese college students.
Training on adequate use of opioid analgesics in West and Central Africa: a neglected step on the way to access to essential medicines?
Authors: Frau Serena , Kananga Anselme Mubeneshayi , Kingolo Jackie Ndona , Kanyunyu Ghislaine Mbelu , Zongwe André Katele H. , Tshilengi Aaron Nshindi , Ravinetto Raffaella 
Published: December 2021

AbstractAlleviating acute and chronic pain is a moral imperative for health professionals and health systems, and it requires adequate access to and use of essential opioid analgesics. However, this is still a neglected issue in global health, with striking inequalities in opioids availability between high and low- and middle-income countries. Countries most affected by lack of access are those with a fragile political situation and weak regulatory and healthcare systems. The main threats to accessibility, availability and affordability are situated at different levels: legislation and policy, financing, knowledge and cultural behavior, erroneous beliefs, and training and education. Among these threats, the lack of (adequate) training and education seems to be a cross-cutting issue. Exploring the current body of knowledge about training and educational activities related to use of opioid analgesics and palliative care, is helpful to understand gaps and to delineate priorities for setting up adequate interventions. When applied to West and Central Africa, this exercise reveals that there is little information (easily) available in the public domain. The African Palliative Care Association (APCA) appears to be the leading provider of capacity building activities in this region for key stakeholders, including national authorities, healthcare professionals and the general population; it is also very active in publishing and communicating about these issues. However, apart from APCA, there is little information on training programs’ contents and long-term outcomes. Furthermore, trainings rarely target important stakeholders such as lawmakers, regulators, supply officers and the lay public (i.e., patients, caregivers, community leaders and members of the society as a whole). Hence, it is urgent to fill the existing gaps in training and educational activities to improve access to essential opioid analgesics in West and Central Africa, involving different stakeholders at the national and regional level. Furthermore, such experiences should be published and made publicly available to allow for mutual learning and further upscale.
Lateral meniscal posterior root tears experience acceptable healing status after transtibial repair technique
Authors: Aga Cathrine , Aasen Ingerid Baksaas , Brocker Carsten , Kise Nina Jullum , Heir Stig 
Published: December 2021

Abstract
Purpose
To evaluate patient MRI results, demography and clinical outcome following transtibial repair of lateral and medial meniscal posterior root tears.

Methods
Patients treated with transtibial repairs of posterior meniscal root tears from 2015 through 2018 performed pre- and postoperative MRI scans. Outcome measures were continuity/discontinuity of the meniscal root and change in meniscal extrusion on MRI. Other outcomes were KOOS, Lysholm score, Tegner activity scale and the Global Rate of Change (GRoC) score for function and pain at follow-up.

Study design
Retrospective case-series.

Results
Of 41 patients, 36 attended follow-up at mean 26 (12–38) months postoperatively. At follow-up, 11 out of 18 lateral meniscus posterior root tear (LMPRT) versus 5 out of 18 medial meniscus posterior root tear (MMPRT) repairs were classified as healed. Meniscal extrusion decreased in LMPRTs from of 2.3 ± 1.5 mm to 1.4 ± 1.09 mm (p = 0.080) and increased in MMPRTs from 3.1 ± 1.6 mm to 4.8 ± 1.9 mm (p = 0.005) at FU (between-group difference, p < 0.001). LMPRT repairs were associated with ACL injury and additional meniscal injury and were younger and with lower BMI. No between-group differences were found for KOOS, Lysholm or GRoC Function scores. Tegner scale was higher and GRoC Pain score lower in the LMPRT group compared to the MMPRTs.

Conclusion
Following transtibial repair for meniscal posterior root repairs, the LMPRTs had a higher frequency of healing, whereas most MMPRTs continued to extrude, despite surgical intervention. The study confirmed that LMPRTs and MMPRTs differ in demography and associated injuries.
Northward expansion trends and future potential distribution of a dragonfly Ischnura senegalensis Rambur under climate change using citizen science data in South Korea
Authors: Shin Sookyung , Jung Kwang Soo , Kang Hong Gu , Dang Ji-Hee , Kang Doohee , Han Jeong Eun , Kim Jin Han 
Published: December 2021

Abstract
Background
Citizen science is becoming a mainstream approach of baseline data collection to monitor biodiversity and climate change. Dragonflies (Odonata) have been ranked as the highest priority group in biodiversity monitoring for global warming. Ischnura senegalensis Rambur has been designated a biological indicator of climate change and is being monitored by the citizen science project “Korean Biodiversity Observation Network.” This study has been performed to understand changes in the distribution range of I. senegalensis in response to climate change using citizen science data in South Korea.

Results
We constructed a dataset of 397 distribution records for I. senegalensis, ranging from 1980 to 2020. The number of records sharply increased over time and space, and in particular, citizen science monitoring data accounted for the greatest proportion (58.7%) and covered the widest geographical range. This species was only distributed in the southern provinces until 2010 but was recorded in the higher latitudes such as Gangwon-do, Incheon, Seoul, and Gyeonggi-do (max. Paju-si, 37.70° latitude) by 2020. A species distribution model showed that the annual mean temperature (Bio1; 63.2%) and the maximum temperature of the warmest month (Bio5; 16.7%) were the most critical factors influencing its distribution. Future climate change scenarios have predicted an increase in suitable habitats for this species.

Conclusions
This study is the first to show the northward expansion in the distribution range of I. senegalensis in response to climate warming in South Korea over the past 40 years. In particular, citizen science was crucial in supplying critical baseline data to detect the distribution change toward higher latitudes. Our results provide new insights on the value of citizen science as a tool for detecting the impact of climate change on ecosystems in South Korea.
Emergency endovascular treatment using a Viabahn stent graft for upper and lower extremity arterial bleeding: a retrospective study
Authors: Ueda Tatsuo , Murata Satoru , Tajima Hiroyuki , Saito Hidemasa , Yasui Daisuke , Sugihara Fumie , Mizushima Shohei , Mine Takahiko , Kawamata Hiroshi , Hayashi Hiromitsu , Kumita Shin-Ichiro 
Published: December 2021

Abstract
Background
A Viabahn stent graft (SG) is a heparin-coated self-expandable SG for lower extremity arterial disease that exhibits high flexibility and accuracy in the delivery system. This study aimed to evaluate the short-term efficacy and safety of emergency endovascular treatment (EVT) using a Viabahn SG for upper and lower extremity arterial bleeding (ULEAB).

Methods
Consecutive patients with ULEAB who underwent emergency EVT using the Viabahn SG between January 2017 and August 2021 were retrospectively reviewed. The indications for EVT, location of artery, technical success, clinical success, limb ischemia, periprocedural complications, bleeding-related mortality, 30-day mortality, diameter of the target artery, diameter of the SG, neck length, rebleeding, endoleaks, and patency of the SGs at 1, 3, 6, and 12 months were evaluated.

Results
EVT using the Viabahn SG was performed in 22 patients (mean age, 72.0 ± 13.0 years; 11 men) and 23 arteries (upper, 6; lower, 17). The indications for EVT were pseudoaneurysm (n = 13, 59.1%), extravasation (n = 9, 39.1%), and inadvertent arterial cannulation (n = 1, 4.3%). The anatomical locations of the 23 ULEAB injuries were the brachiocephalic (1 [4.3%]), subclavian (3 [13.0%]), axillary (1 [4.3%]), brachial (1 [4.3%]), common iliac (4 [17.4%]), external iliac (8 [34.8%]), common femoral (2 [8.7%]), superficial femoral (2 [8.7%]), and popliteal (1 [4.3%]) arteries. The technical and clinical success rates were 100%. The rates of limb ischemia, periprocedural complications, and bleeding-related mortality were 0%, whereas the 30-day mortality rate was 22.7%. The mean diameters of the arteries and SGs were 7.7 ± 2.2 and 8.9 ± 2.3 mm, respectively. The mean neck length was 20.4 ± 11.3 mm. No endoleaks or rebleeding occurred during the follow-up period (mean, 169 ± 177 days). Two SG occlusions without limb ischemia occurred in the external iliac and brachial arteries after 1 and 4 months, respectively. Subsequently, cumulative SG patency was confirmed after 1, 3, 6, and 12 months in 91.7%, 91.7%, 81.5%, and 81.5% of patients, respectively.

Conclusions
Emergency EVT using the Viabahn SG for ULEAB was effective and safe according to short-term outcomes. Appropriate size selection and neck length are important for successful treatment. SG patency was good after 1, 3, 6, and 12 months.
Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review
Authors: Ugwu Chidiebere Emmanuel , Suru Stephen Monday 
Published: December 2021

Abstract
Background
Carbon tetrachloride (CCl4) is a well-characterized hepatotoxic agent. With rising cases of liver diseases, the identification, assessment, and development of hepatoprotective agents from plants source has become imperative.

Main body
With arrays of literature on plants with hepatoprotective potentials, this review sourced published literatures between 1998 and 2020 and systematically highlighted about 92 medicinal plants that have been reported to protect against CCl4-induced liver injury in animal models. The results show that herbal plants provide protection for the liver against CCl4 by downregulation of the liver marker enzymes and activation of antioxidant capacity of the liver cells with the restoration of liver architecture. We also provided the traditional and accompanying pharmacological uses of the plants. A variety of phytochemicals mostly flavonoids and polyphenols compounds were suggested to offer protection against liver injuries.

Conclusion
It can be concluded that there are a variety of phytochemicals in plant products with hepatoprotective activity against CCl4-induced toxicity in animal models.
Evaluation of outcome after primary median and/or ulnar nerve(s) repair at wrist: clinical, functional, electrophysiologic, and ultrasound study
Authors: Hassan Nahla Ahmed , Elsawy Noha Abdelhalim , Kotb Hesham Hussien , El-Hamid Mowaffak Mostafa Abd , El Emairy Wafaa Samir , Kholosy Hassan Mahmoud 
Published: December 2021

AbstractBackgroundA major problem in surgery of peripheral nerve injuries of the upper extremities is the unpredictable final outcome. More insight and understanding of the proper methods of outcome assessment and the prognostic factors is necessary to improve functional outcome after repair of peripheral nerves. The objective of this study is to assess the outcome and identify possible prognostic factors for functional recovery of median and/or ulnar nerves repairs at wrist. Forty patients with median, ulnar or combined median-ulnar nerve injuries were included. Smoking, age, sex, repaired nerve, associated artery and/ or tendon repairs, joint stiffness and scar tissue were analyzed as prognostic factors for functional outcome after repair. Outcome parameters were medical research counsel (MRC) scoring for sensory and motor recovery, grip and pinch strength, disability of arm, shoulder and hand (DASH) questionnaire, electrophysiology and ultrasonographic evaluation.ResultsThe mean age of the studied patients was 29.1 ± 8.3 and it was statistically correlated with grip strength (p= 0.045), DASH score (p= 0.046) and hyperesthesia score (p= 0.040). EMG results showed signs of regeneration in all patients in the form of small nascent MUAPs and polyphasic MUAPs. CMAP amplitudes of median and ulnar nerves positively correlated with the MRC scale for muscle strength (p= 0.001)There were statistically significant negative correlations between DASH score and MRC score for sensory evaluation (p= 0.016), grip (p= 0.001), and pinch strength (p= 0.001). There were statistically significant positive correlations between patient's opinion of recovery and MRC score for sensory evaluation (p= 0.029), grip (p= 0.001), and pinch strength (p= 0.001). The MRC score for muscle strength has statistical significant positive correlations with the MRC score for sensory evaluation, grip (p= 0.003), and pinch strength (p= 0.040)ConclusionsIt was concluded that; MRC scale for muscle power, MRC scale for sensory evaluation, functional scores, grip and pinch strength are valuable tools for evaluation of functional outcome. Age, smoking, associated tendon repair, damaged nerve, compliance to rehabilitation protocol, return to work, clinically visible wound adhesions, residual hand joint stiffness, and scar tissue detected by ultrasound were found to be prognostic factors for outcome after nerve repair.
Randomized Controlled Phase II Evaluation of Two Dose Levels of Bupropion Versus Placebo for Sexual Desire in Female Cancer Survivors: NRG-CC004
Authors: Barton Debra L. , Pugh Stephanie L. , Ganz Patricia A. , Plaxe Steven C. , Koontz Bridget F. , Carter Jeanne , Greyz-Yusupov Natalya , Page Seth J. , Rowland Kendrith M. , Balcueva Ernie P. , Nabeel Sobia , Basil Jack B. , Hill Matthew L. , Muller Carolyn Y. , Bell Maria C. , Deshmukh Snehal , Kachnic Lisa A. 
Published: December 2021

PURPOSE Because of the negative impact of cancer treatment on female sexual function, effective treatments are warranted. The purpose of this multisite study was to evaluate the ability of two dose levels of extended-release bupropion, a dopaminergic agent, to improve sexual desire more than placebo at 9 weeks, measured by the desire subscale of the Female Sexual Function Index (FSFI), and to evaluate associated toxicities. METHODS Postmenopausal women diagnosed with breast or gynecologic cancer and low baseline FSFI desire scores (< 3.3), who had completed definitive cancer therapy, were eligible. Women were randomly assigned to receive 150 mg or 300 mg once daily of extended-release bupropion or a matching placebo. t-tests were performed on the FSFI desire subscale to evaluate whether there was a significantly greater change from baseline to 9 weeks between placebo and each bupropion arm as the primary end point. Sixty-two patients per arm provided 80% power using a one-sided t-test. RESULTS Two hundred thirty women were randomly assigned from 72 institutions through the NRG Oncology NCORP network. At 9 weeks, there were no statistically significant differences in change of the desire subscale scores between groups; participants in all three arms reported improvement. The mean changes for each arm were placebo 0.62 (standard deviation [SD] = 1.18), 150-mg once daily bupropion 0.64 (SD = 0.95), and 300-mg once daily bupropion 0.60 (SD = 0.89). Total and subscale scores on the FSFI were low throughout the study, indicating dysfunction in all groups. CONCLUSION Bupropion was not more effective than placebo in improving the desire subscale of the FSFI. Subscale and total scores of the FSFI demonstrated dysfunction throughout the 9 weeks of the study. More research is needed to support sexual function in female cancer survivors.
On the von Neumann entropy of language networks: Applications to cross-linguistic comparisons
Authors: Vera Javier , Fuentealba Diego , Lopez Mario , Ponce Hector , Zariquiey Roberto 
Published: December 2021

Abstract
Words are not isolated entities within a language. In this paper, we measure the number of choices transmitted in natural language by means of the von Neumann entropy of language networks. This quantity, introduced in Quantum Information accounts, provides a detailed characterization of network complexities. The simulations are based on a large parallel corpus of 362 languages across 55 linguistic families (focusing on the sub-sample of 85 languages from the Americas). With this, we constructed language networks as a simple way to describe word connectivity patterns for each language. We studied several aspects of the von Neumann entropy of language networks. First, we discovered large groups of languages with low average degree and high von Neumann entropy. The results suggested also that large von Neumann entropy is associated with word entropy (as a proxy for morphological complexity), and is inversely related to degree regularity. This means that there are pressures at play that keep a balance between word morphological complexity and patterns of connections between words. We suggested also a strong influence of functional words on low von Neumann entropy languages. Our approach is thus a simple network-based contribution to establish cross-linguistic language comparisons from textual data.
Cognitive Rehabilitation
Authors: Kirsch-Darrow Lindsey , Tsao Jack W. 
Published: December 2021

ABSTRACT

PURPOSE OF REVIEW
This article provides a definition of and introduction to cognitive rehabilitation. It discusses different approaches to cognitive rehabilitation (ie, restorative, compensatory, and metacognitive). It also reviews types of memory impairment and how they can be distinguished to improve treatment design and implementation.

RECENT FINDINGS
Neural plasticity as a biological substrate for functional changes from cognitive rehabilitation is an exciting new area of research.

SUMMARY
This article provides a high-level review of cognitive rehabilitation and presents a complex case example.
Lateral Supracerebellar Infratentorial Approach for Superior Oblique Myokymia: A Case Series
Authors: Noro Shusaku , Seo Yoshinobu , Honjo Kaori , Okuma Masahiro , Asayama Bunsho , Amano Yuki , Kyono Masanori , Hashimoto Masato , Hanai Kaori , Nakamura Hirohiko 
Published: December 2021

BACKGROUND:
Few reports have shown that superior oblique myokymia (SOM) may result from vascular compression of the trochlear nerve and may be curable using microvascular decompression (MVD).

OBJECTIVE:
To report the clinical characteristics and surgical treatment of 2 cases of SOM and provide a review of the related literature.

METHODS:
Two patients with SOM were treated using MVD with the lateral supracerebellar infratentorial approach. The patients underwent diagnostic magnetic resonance imaging and three-dimensional fusion imaging preoperatively. A lateral suboccipital craniotomy was performed in the park-bench position. The trochlear nerve and branches of the superior cerebellar artery were confirmed after opening the cerebellomesencephalic fissure over the tentorial surface of the cerebellum. The vessel, which compressed the root exit zone of the trochlear nerve, was transposed far from the nerve and attached to the surface of the midbrain using Teflon felt and fibrin glue.

RESULTS:
The first case showed compression on both the ventral and rostral sides of the trochlear nerve root exit zone, and the second showed compression only on the ventral side. Large bridging veins on the tentorial surface of the cerebellum complicated the approach in the second case. Postoperatively, both patients had immediate and complete resolution of symptoms without recurrence at the 24-mo and 17-mo follow-ups, respectively. Five previous reports described the complete resolution of SOM after MVD.

CONCLUSION:
A presentation of an intermittent fluttering ocular sensation should prompt magnetic resonance imaging for ipsilateral trochlear nerve compression. The lateral supracerebellar infratentorial approach allows safe and efficacious MVD for SOM.