bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Variasi Waktu Radiasi Plasma Pijar Korona Terhadap Viabilitas, Vigor Benih, Laju Perkecambahan dan Pertumbuhan Kangkung Darat (Ipomoea reptans poir)
Authors: Kuwati Kuwati , Prihastanti Erma 
Published: October 2021

Permintaan sayuran semakin lama semakin meningkat. Peningkatan permintaan sayuran harus diimbangi dengan produktivitas. Kangkung darat merupakan sayuran daun yang penting di kawasan Asia. Kandungan gizi kangkung cukup tinggi terutama vitamin A dan vitamin C. Saat ini teknologi plasma dapat digunakan dalam bidang pertanian. Plasma lucutan pijar korona merupakan sumber ion, elektron, dan radikal bebas. Udara bebas mengandung banyak gas yang tidak dapat terserap langsung oleh tanaman. Radiasi plasma mampu mengionisasi gas dari udara menjadi bentuk ion yang ditembakkan dalam suatu bahan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi waktu radiasi plasma terhadap viabilitas, laju perkecambahan dan laju pertumbuhan biji kangkung darat. Penelitian dilakukan di Laboratorium CPR (Center Plasma Research), Universitas Diponegoro. Rancangan penelitian yang digunakan adalah rancangan acak lengkap (RAL), dengan perlakuan perbedaan lama radiasi waktu 0, 10 menit, dan 20 menit dan pengulangan 3 kali. Parameter yang diamati viabilitas, vigor benih, dan laju perkecambahan tanaman kangkung darat. Analisis data menggunakan uji ANOVA dan uji lanjut duncan dengan taraf signifikasi 0.05. Perlakuan radiasi selama 20 menit, 10 menit dan kontrol memberikan hasil rata – rata viabilitas 87%; 73%; dan 53%, laju perkecambahan 2,1 n/hari; 2,1 n/hari; dan 2,08 n/hari pada kangkung darat. Kata kunci : radiasi, plasma pijar korona, viabilitas, vigor benih
Pengaruh Pematahan Dominansi Apikal terhadap Produktivitas Tanaman Kacang-Kacangan
Authors: Hastuti Endah Dwi , Saptiningsih Endang , Izzati Munifatul 
Published: October 2021

Peningkatan konsumsi berbagai jenis kacang-kacangan di Indonesia saat ini mendorong adanya upaya peningkatan produktivitas tanaman. Penelitian ini bertujuan untuk mengkaji pengaruh pematahan dominansi apikal terhadap produktivitas tanaman kacang-kacangan, meliputi waktu pembungaan, jumlah polong, jumlah biji dan berat basah dan berat kering polong, mengkaji sifat polong yang dihasilkan. Penelitian dilakukan pada Laboratorium Biologi Struktur dan Fungsi Tumbuhan, Fakultas Sains dan Matematika Universitas Diponegoro antara April hingga Desember 2018. Materi percobaan meliputi jenis kacang, yaitu kacang kedelai, kacang hijau, kacang tanah, kacang merah dan kacang tolok, sedangkan perlakuan berupa pematahan dominansi apikal dengan pemotongan pucuk tanaman. Analisis data dilakukan dengan ANOVA. Hasil penelitian menunjukkan adanya variasi pada waktu pembungaan, jumlah polong, jumlah biji, berat basah dan berat kering polong yang dihasilkan. Perbedaan yang signifikan hanya teramati pada jumlah biji yang dihasilkan berdasarkan jenis kacang. Secara umum, produktivitas kacang merah merupakan yang paling tinggi dengan 7,8 polong/tanaman, namun berdasarkan jumlah biji yang dihasilkan kacang hijau memiliki produktivitas yang paling tinggi dengan 29 biji/tanaman. Sifat polong yang dihasilkan dari masing-masing jenis kacang menunjukkan adanya variasi terhadap rasio berat kering:berat basah yang dihasilkan. Rasio berat kacang yang dihasilkan berturut-turut 87,2%; 72,3%; 33,0%; dan 23,3% masing-masing untuk kacang hijau, kacang merah, kacang kedelai dan kacang tanah. Kata kunci: berat, kacang-kacangan, polong, produktivitas, rasio
Fermentasi Ampas Sagu (FAS) sebagai Pakan Alternatif Untuk Meningkatan Pertumbuhan Bobot Ayam Kampung
Authors: Suebu Yusuf , Tanjung Rosye H.R. , Suharno Suharno 
Published: October 2021

Sagu (Metroxylon sagu) merupakan tanaman kelompok palm yang mengandung zat pati tinggi, dan telah dimanfaatkan sebagai bahan pangan pokok bagi masyarakat Papua. Semua bagian dari tanaman ini dimanfaatkan untuk kebutuhan manusia. Namun, ampas sebagai bagian dari sisa produk zat pati belum dimanfaatkan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh fermentasi ampas sagu (FAS) sebagai pakan alternatif untuk pertumbuhan ayam kampung. Penelitian ini dilakukan dengan metode Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan, yaitu : P0 =Kontrol (PB 100% dan FAS 0%), P1 =PB 96% dan FAS 4%, P2 =PB 92% dan FAS 8%, dan P3 =PB 88% dan FAS 12%. Parameter yang diukur antara lain adalah tinggi badan dan bobot ayam. Analisis dilakukan pada ampas sagu baik sebelum fermentasi maupun setelah proses fermentasi. Hasil analisis menunjukkan bahwa FAS mengandung protein kasar, serat kasar, dan lemak kasar mengalami peningkatan masing-masing sebesar 66,5%, 21,1%, 54,5% dibandingkan sebelum dilakukan fermentasi. Perlakuan FAS tidak memberikan pengaruh terhadap peningkatan tinggi tubuh ayam kampung. Perlakuan signifikan nampak pada parameter bobot tubuh ayam kampung. Peningkatan terbaik bobot ayam terjadi pada perlakuan P1 (PB 96% dan FAS 4%). Perlakuan P1 mampu meningkatkan bobot ayam hingga mencapai 17,8%, sedangkan P2 mencapai 10%. FAS dapat dimanfaatkan sebagai pakan alternatif dalam meningkatkan pertumbuhan bobot ayam kampung. Kata kunci : sagu, fermentasi, pertumbuhan, ayam kampung
Struktur Hepar dan Rasio Bobot Hepar Terhadap Bobot Tubuh Mencit (Mus Musculus L.) Jantan Setelah Pemberian Ekstrak Etanol Daun Mimba (Azadirachta Indica A.Juss)
Authors: Fitriani Ratih Nur , Sitasiwi Agung Janika , Isdadiyanto Sri 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui struktur hepar dan rasio bobot hepar terhadap bobot tubuh mencit (Mus musculus L) jantan setelah pemberian ekstrak etanol daun mimba (Azadirachta indica A.Juss). Penelitian ini menggunakan 2 kelompok perlakuan yaitu Kontrol (akuades) dan Perlakuan (mimba). Perlakuan diberikan secara oral selama 21 hari. Hepar ditimbang dan dibuat preparat menggunakan metode parafin dengan pewarnaan Hematoksilin Eosin. Pengukuran diameter hepatosit dilakukan dalam 4 bidang pandang. Bobot hepar dan bobot tubuh digunakan untuk menghitung nilai HSI. Data dianalisis dengan uji t. Hasil analisis menunjukan adanya pengaruh nyata terhadap diameter hepatosit tetapi menunjukan pengaruh tidak nyata terhadap bobot tubuh, bobot hepar dan nilai Hepatosomatik indek (HSI). Hal ini dapat disimpulkan bahwa pemberian ekstrak etanol daun mimba (Azadirachta indica) sebagai obat tradisional dengan dosis 14 mg/KgBB tidak mempengaruhi struktur hepar dan rasio bobot hepar terhadap bobot tubuh mencit (Mus musculus) jantan. Kata kunci : daun mimba, hepar, diameter hepatosit dan HSI
Copularity of French and Dutch (semi-)copular constructions: a behavioral profile analysis
Authors: Van Wettere Niek 
Published: October 2021

AbstractThis study aims to characterize prototypical copularity in contrast with semi-copulas based on probabilistic distributional traits, which indicate preferential associations rather than absolute restrictions. This evaluation of prototypical copularity will be based on a set of 15 French and Dutch copular verbs. A behavioral profile analysis, involving multiple clustering procedures, will demonstrate that (i) prototypical copulas and semi-copulas are never clustered together in one group and that (ii) the group of prototypical copulas is more homogeneous in comparison with the groups of semi-copulas. Next, the bipartition [prototypical copulas vs. semi-copulas] is examined by means of a Firth logistic regression. Overall, it is shown for both French and Dutch that the pattern [(in)animate subject + prepositional SC] is clearly associated with the semi-copulas, whereas the pattern [inanimate subject + nominal SC] is the most distinctive for the prototypical copulas.
VSTM1 regulates monocyte/macrophage function via the NF-κB signaling pathway
Authors: Wang Xiao-Fei , En-Zhou  , Li Dong-Jiu , Mao Cheng-Yu , He Qing , Zhang Jun-Feng , Fan Yu-Qi , Wang Chang-Qian 
Published: October 2021

Abstract

Objective
V-set and transmembrane domain-containing protein 1 (VSTM1) is negatively correlated with inflammation. However, its effect on atherosclerosis (AS) remains largely unexplored. In this study, we aimed to assess the effect of VSTM1 on the biological function of human peripheral blood mononuclear cells /macrophages stimulated by oxidized low-density lipoprotein (ox-LDL).

Methods
U937 cells were divided into three groups as follows: control group, pLenti-VSTM1 shRNA group (VSTM1 depletion), and pLenti-VSTM1 group (VSTM1 overexpression). Cellular migration, chemotaxis, apoptosis, and secretion of inflammatory factors of monocytes/macrophages stimulated by ox-LDL were studied.

Results
Overexpression of VSTM1 decreased the proliferation of U937 cells and induced cellular apoptosis. Depletion of VSTM1 enhanced the invasiveness and chemotaxis, increased the inflammatory response, and reduced the incidence of cell necrosis and apoptosis. Nuclear factor κ of B cells (NF-κB) was activated in VSTM1-depleted U937 cells.

Conclusion
VSTM1 might play an important role in the activation of monocytes/macrophages and participate in the pathogenesis of AS via regulating NF-κB activity.
Modeling Physiological Sources of Heading Bias from Optic Flow
Authors: Yumurtaci Sinan , Layton Oliver W. 
Published: October 2021

AbstractHuman heading perception from optic flow is accurate for directions close to the straight-ahead and systematic biases emerge in the periphery (Cuturi and Macneilage, 2013; Sun et al., 2020). In pursuit of the underlying neural mechanisms, primate brain dorsal medial superior temporal (MSTd) area has been a focus because of its causal link with heading perception (Gu et al., 2012). Computational models generally explain heading sensitivity in individual MSTd neurons as a feedforward integration of motion signals from medial temporal (MT) area that resemble full-field optic flow patterns consistent with the preferred heading direction (Britten, 2008; Mineault et al., 2012). In the present simulation study, we quantified within the structure of this feedforward model how physiological properties of MT and MSTd shape heading signals. We found that known physiological tuning characteristics generally supported the accuracy of heading estimation, but not always. A weak-to-moderate overrepresentation of peripheral headings in MSTd garnered the highest accuracy and precision out of the models that we tested. The model also performed well when noise corrupted high proportions of the optic flow vectors. Such a peripheral MSTd model performed well when units possessed a range of receptive field (RF) sizes and were strongly direction tuned. Physiological biases in MT direction tuning toward the radial direction also supported heading estimation, but the tendency for MT preferred speed and RF size to scale with eccentricity did not. Our findings help elucidate the extent to which different physiological tuning properties influence the accuracy and precision of neural heading signals.
Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons
Authors: Plooster Melissa , Rossi Guendalina , Farrell Martilias S. , McAfee Jessica C. , Bell Jessica L. , Ye Michael , Diering Graham H. , Won Hyejung , Gupton Stephanie L. , Brennwald Patrick 
Published: October 2021

TSNARE1, which encodes the protein tSNARE1, is a high-confidence gene candidate for schizophrenia risk, but nothing is known about its cellular or physiological function. We identified the major gene products ofTSNARE1and their cytoplasmic localization and function in endosomal trafficking in cortical neurons. We validated three primary isoforms ofTSNARE1expressed in human brain, all of which encode a syntaxin-like Qa SNARE domain. RNA-sequencing data from adult and fetal human brain suggested that the majority of tSNARE1 lacks a transmembrane domain that is thought to be necessary for membrane fusion. Biochemical data demonstrate that tSNARE1 can compete with Stx12 for incorporation into an endosomal SNARE complex, supporting its possible role as an inhibitory SNARE. Live-cell imaging in cortical neurons from mice of both sexes demonstrated that brain tSNARE1 isoforms localized to the endosomal network. The most abundant brain isoform, tSNARE1c, localized most frequently to Rab7+late endosomes, and endogenous tSNARE1 displayed a similar localization in human neural progenitor cells and neuroblastoma cells. In mature rat neurons from both sexes, tSNARE1 localized to the dendritic shaft and dendritic spines, supporting a role for tSNARE1 at the postsynapse. Expression of either tSNARE1b or tSNARE1c, which differ only in their inclusion or exclusion of an Myb-like domain, delayed the trafficking of the dendritic endosomal cargo Nsg1 into late endosomal and lysosomal compartments. These data suggest that tSNARE1 regulates endosomal trafficking in cortical neurons, likely by negatively regulating early endosomal to late endosomal trafficking.SIGNIFICANCE STATEMENTSchizophrenia is a severe and polygenic neuropsychiatric disorder. Understanding the functions of high-confidence candidate genes is critical toward understanding how their dysfunction contributes to schizophrenia pathogenesis.TSNARE1is one of the high-confidence candidate genes for schizophrenia risk, yet nothing was known about its cellular or physiological function. Here we describe the major isoforms ofTSNARE1and their cytoplasmic localization and function in the endosomal network in cortical neurons. Our results are consistent with the hypothesis that the majority of brain tSNARE1 acts as a negative regulator to endolysosomal trafficking.
Contralateral Projection of Anterior Cingulate Cortex Contributes to Mirror-Image Pain
Authors: Hu Su-Wan , Zhang Qi , Xia Sun-Hui , Zhao Wei-Nan , Li Qi-Ze , Yang Jun-Xia , An Shuming , Ding Hai-Lei , Zhang Hongxing , Cao Jun-Li 
Published: October 2021

Long-term limb nerve injury often leads to mirror-image pain (MIP), an abnormal pain sensation in the limb contralateral to the injury. Although it is clear that MIP is mediated in part by central nociception processing, the underlying mechanisms remain poorly understood. The anterior cingulate cortex (ACC) is a key brain region that receives relayed peripheral nociceptive information from the contralateral limb. In this study, we induced MIP in male mice, in which a unilateral chronic constrictive injury of the sciatic nerve (CCI) induced a decreased nociceptive threshold in both hind limbs and an increased number of c-Fos-expressing neurons in the ACC both contralateral and ipsilateral to the injured limb. Using viral-mediated projection mapping, we observed that a portion of ACC neurons formed monosynaptic connections with contralateral ACC neurons. Furthermore, the number of cross-callosal projection ACC neurons that exhibited c-Fos signal was increased in MIP-expressing mice, suggesting enhanced transmission between ACC neurons of the two hemispheres. Moreover, selective inhibition of the cross-callosal projection ACC neurons contralateral to the injured limb normalized the nociceptive sensation of the uninjured limb without affecting the increased nociceptive sensation of the injured limb in CCI mice. In contrast, inhibition of the non–cross-callosal projection ACC neurons contralateral to the injury normalized the nociceptive sensation of the injured limb without affecting the MIP exhibited in the uninjured limb. These results reveal a circuit mechanism, namely, the cross-callosal projection of ACC between two hemispheres, that contributes to MIP and possibly other forms of contralateral migration of pain sensation.SIGNIFICANCE STATEMENTMirror-image pain (MIP) refers to the increased pain sensitivity of the contralateral body part in patients with chronic pain. This pathology requires central processing, yet the mechanisms are less known. Here, we demonstrate that the cross-callosal projection neurons in the anterior cingulate cortex (ACC) contralateral to the injury contribute to MIP exhibited in the uninjured limb, but do not affect nociceptive sensation of the injured limb. In contrast, the non–cross-callosal projection neurons in the ACC contralateral to the injury contribute to nociceptive sensation of the injured limb, but do not affect MIP exhibited in the uninjured limb. Our study depicts a novel cross-callosal projection of ACC that contributes to MIP, providing a central mechanism for MIP in chronic pain state.
Interconception Care and Safe Sleep: Adapting the IMPLICIT Toolkit for Pediatrics
Authors: Scott Emily , Casavan Kara , Swigonski Nancy 
Published: October 2021

BACKGROUND
A woman’s health in the interconception period has an impact on birth outcomes. Pediatric visits offer a unique opportunity to provide interconception care (ICC). Our aim was to screen and provide interconception and safe sleep screening, counseling, and interventions for 50% of caregivers of children &lt;2 years of age in a pediatric medical setting.

METHODS
Two pediatric clinics implemented the March of Dimes’ Interventions to Minimize Preterm and Low Birth Weight Infants Through Continuous Improvement Techniques (IMPLICIT) toolkit, in addition to standardized safe sleep assessments. A quality improvement learning collaborative was formed with a local “infant mortality champion” leading quality improvement efforts. Monthly webinars with the clinic teams reviewed project successes and challenges. Framework for Reporting Adaptations and Modifications was used to document adaptations.

RESULTS
For each individual IMPLICIT domain, clinics screened and provided needed interventions for ICC and safe sleep in &gt;50% of eligible encounters. Over the course of the quality improvement learning collaborative, the number of caregivers screened for at least 4 of the 5 IMPLICIT domains increased from 0% to 95%.

CONCLUSIONS
To successfully implement the IMPLICIT toolkit in pediatrics, adaptations were made to the existing model, which had previously been used in family medicine clinics. Pediatricians should consider providing ICC as an innovative way to impact infant mortality rates in their community. Framework for Reporting Adaptations and Modifications can be used to systematically describe the adaptations needed to improve the fit of IMPLICIT in the pediatric clinic, understand the process of change and potential application to local context.
Birth Hospital Length of Stay and Rehospitalization During COVID-19
Authors: Handley Sara C. , Gallagher Kieran , Breden Amy , Lindgren Eric , Lo Justin Y. , Son Moeun , Murosko Daria , Dysart Kevin , Lorch Scott A. , Greenspan Jay , Culhane Jennifer F. , Burris Heather H. 
Published: October 2021

OBJECTIVES
To determine if birth hospitalization length of stay (LOS) and infant rehospitalization changed during the coronavirus disease 2019 (COVID-19) era among healthy, term infants.

METHODS
Retrospective cohort study using Epic’s Cosmos data from 35 health systems of term infants discharged ≤5 days of birth. Short birth hospitalization LOS (vaginal birth &lt;2 midnights; cesarean birth &lt;3 midnights) and, secondarily, infant rehospitalization ≤7 days after birth hospitalization discharge were compared between the COVID-19 (March 1 to August 31, 2020) and prepandemic eras (March 1 to August 31, 2017, 2018, 2019). Mixed-effects models were used to estimate adjusted odds ratios (aORs) comparing the eras.

RESULTS
Among 202 385 infants (57 110 from the COVID-19 era), short birth hospitalization LOS increased from 28.5% to 43.0% for all births (vaginal: 25.6% to 39.3%, cesarean: 40.1% to 61.0%) during the pandemic and persisted after multivariable adjustment (all: aOR 2.30, 95% confidence interval [CI] 2.25–2.36; vaginal: aOR 2.12, 95% CI 2.06–2.18; cesarean: aOR 3.01, 95% CI 2.87–3.15). Despite shorter LOS, infant rehospitalizations decreased slightly during the pandemic (1.2% to 1.1%); results were similar in adjusted analysis (all: aOR 0.83, 95% CI 0.76–0.92; vaginal: aOR 0.82, 95% CI 0.74–0.91; cesarean: aOR 0.87, 95% CI 0.69–1.10). There was no change in the proportion of rehospitalization diagnoses between eras.

CONCLUSIONS
Short infant LOS was 51% more common in the COVID-19 era, yet infant rehospitalization within a week did not increase. This natural experiment suggests shorter birth hospitalization LOS among family- and clinician-selected, healthy term infants may be safe with respect to infant rehospitalization, although examination of additional outcomes is needed.
Choosing love, marriage and the traditional role
Authors: Montiel McCann Camila 
Published: October 2021

Stereotypes of white women have historically limited their identities to that of wife and mother. Though restrictive, this type of femininity has been mobilised to create hierarchies of womanhood that legitimate this form and subordinate others. However, social change since the feminist second wave has seen the renegotiation of women’s position, and contemporary antiracist and LGBTQIA+ discourse has seen further departure from traditional ideals of femininity. Mass media is a dominant site where controlling images of women are negotiated and in which dominant, or hegemonic, forms emerge. This article applies Feminist Critical Discourse Analysis to examine popular British gossip magazine Heat’s romance and sex narratives for discourse which (re)produces, negotiates or challenges hegemonic femininity. Through the appropriation of feminist language, Heat propagates an updated hegemonic femininity which preserves the racio-patriarchal discourse of gender difference whilst pacifying feminist audiences. Estereótipos de mulheres brancas historicamente limitam suas identidades aos papéis de esposas e mães. Embora redutoras, essas categorias têm sido mobilizadas com o objetivo de criar hierarquias de feminilidade que as legitimam enquanto subordinam outras formas do feminino. Contudo, desde a segunda onda do feminismo, mudanças sociais relativas à renegociação do lugar da mulher assim como discursos antirracistas e pró-LGBTQIA+ têm possibilitado um distanciamento dos ideais tradicionais de feminilidade. A mídia de massa veicula imagens de mulheres que acabam se tornando dominantes e hegemônicas. Este artigo aplica a Análise Feminista Crítica do Discurso a narrativas de romance e sexo veiculadas na popular revista inglesa Heat e investiga discursos que (re)produzem, negociam ou desafiam a feminilidade hegemônica. Através da apropriação do discurso feminista, a revista Heat propaga uma versão atualizada de feminilidade hegemônica que preserva discursos patriarcais racializados da diferença de gênero ao mesmo tempo em que tenta apaziguar o público feminista.
Psychiatric Complications in Patients with COVID-19: A Narrative Review
Authors: Hashemi Seyyed Mohammad , Nobakht Morteza , Ghazalgoo Arezoo , Ghadamgah Amirhossein , Kargar-Abarghouei Elias , Arab Firouzjaei Maryam 
Published: October 2021

Coronavirus disease 2019 (COVID-19) is associated with severe multiorgan clinical manifestations. Although respiratory involvement is the predominant manifestation in patients infected with COVID-19, involvement of other organs, such as the nervous system, has also been identified; which highlights the virus' ability to disrupt the organs’ function. There is ample evidence of a nervous system susceptibility to the COVID-19. In this regard, the COVID-19 pandemic effect on psychological health, including insomnia, anxiety, obsessive-compulsive disorder, and depression among health care workers and other high-risk groups has been identified. So far, many studies have examined the psychiatric manifestations in infected patients with COVID-19. Undoubtedly, awareness of these findings can help in the prevention and timely treatment of these patients. This study aimed to review the possible mechanisms of COVID-19 neuroinvasive potential, psychiatric manifestations, and the management of mental disorders in infected patients.