bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Visual Feedback During Ultrasound-Guided Interfascial Injection for Myofascial Pain Syndrome: A Prospective, Multicenter, Observational Clinical Trial
Authors: Hasuo Hideaki , Oomori Hideya , Yoshida Kohei , Fukunaga Mikihiko 
Published: February 2021

Abstract
Background: Expectations for treatment have a favorable effect on the subsequent course of pain and behavior in patients. It is not known whether receiving interfascial injection while patients view their ultrasound image with doctors (visual feedback) is associated with positive treatment expectations. Methods: This was a prospective, multicenter, observational clinical trial. We evaluated whether visual feedback during ultrasound-guided interfascial injection affects treatment expectations and the subsequent course of pain in patients with myofascial pain syndrome. Treatment expectations were set as mediators of pain using path analysis. The primary endpoint was the proportion of patients who showed improvement in pain numerical rating scale score by 50% or more 14 days after initiation of treatment. Results: During 2019 and 2020, 136 outpatients received ultrasound-guided interfascial injection for myofascial pain syndrome. Of these, 65 (47.8%) patients received visual feedback during ultrasound-guided interfascial injection. Compared with the non-visual feedback group, the visual feedback group had higher expectations for treatment, immediately after interfascial injection, and their expectations were maintained at day 14 of treatment (p < .001). In the visual feedback group, 67.7% of patients showed improvement in pain numerical rating scale score by 50% or more at day 14 (95% confidence interval: 56.5–78.9), whereas such improvement was observed in only 36.6% of the non-visual feedback group (95% confidence interval: 25.3–47.9; p < .001). Path analysis revealed that visual feedback had the largest influence on pain numerical rating scale reduction at 14 days, which was indirectly via higher expectations for treatment (β = 0.434).Conclusions: Visual feedback during ultrasound-guided interfascial injection had a positive effect on the subsequent course of pain in patients with myofascial pain syndrome by increasing patients’ treatment expectations.Trial registration: UMIN000043160. Registered 28 January 2021 (registered retrospectively).
Living with singleness: needs and concerns of never-married women over 35
Authors: Shahrak Shakiba Pourasad , Brand Serge , Taghizadeh Ziba 
Published: February 2021

Abstract
Background: Cultural and religious norms and expectations may influence the needs and behavior of single women. This is particularly true in those countries where religion and cultural expectations are salient in everyday life. In this context, the present study investigated the needs and concerns of Iranian never-married women aged 35 and older.Methods: This qualitative study involved a conventional content analysis. Interviews were done with 23 never-married women aged 36-64 years in Iran.Results: A total of 773 codes, 22 subcategories, 8 categories, and 3 themes were extracted from the interviews. The 3 themes were: 1. mental-spiritual lack; categories were lack of emotional support, uncertain future, mental rumination, and sexual worries; 2. reform of culture and society; categories were adverse effect of culture and being overlooked in society; 3. loneliness arising from disability; categories were aging and loneliness and sickness and loneliness.Conclusions: The results of the analysis indicate that the needs and concerns of never-married women over the age of 35 years in Iran remain unmet. This suggests that policymakers and health planner should take into consideration the growing number of never-married women as a societal reality deserving of attention.
Cardiac energetics alteration in chronic hypoxia rat model: a non invasive in vivo 31P magnetic resonance spectroscopy experimental study
Authors: Yuan Xiaohan , Zhu Xiaomei , Chen Yang , Liu Wangyan , Qian Wen , Xu Yi , Zhu Yinsu 
Published: February 2021

Abstract
Background: Energetics alteration plays a key role in the process of myocardial injury in chronic hypoxic diseases (CHD). 31P magnetic resonance spectroscopy (MRS) can investigate alterations in cardiac energetics in vivo. This study was aimed to characterize the potential value of 31P MRS in evaluating cardiac energetics alteration of chronic hypoxia rats (CHR).Methods: Twenty-four CHRs were induced by SU5416 combined with hypoxia, and six rats were raised as control group. 31P MRS was performed weekly and the ratio of concentrations of phosphocreatine (PCr) to adenosine triphosphate (ATP) (PCr/ATP) was obtained. The index of cardiac structure and systolic function parameters, including the right ventricular function (RVEF), right ventricular end-diastolic volume index (RVEDVi), right ventricular end-systolic volume index (RVESVi), the left ventricular function parameters were also measured.Results: The declension of resting cardiac PCr/ATP ratio in CHR was observed at the 1st week, compared to control group (2.90±0.35 vs. 3.31±0.45, p =0.045), while the RVEF，RVEDVi and RVESVi decreased at the 2nd week (p＜0.05). The PCr/ATP ratio displayed a significant correlation with RVEF(r = 0.605, p = 0.001)，RVEDVi and RVESVi (r = -0.661, r = -0.703; p＜0.001).Conclusions: 31P MRS can early detect the cardiac energetics alteration in CHR model before the onset of ventricular dysfunction. The decrease of PCr/ATP ratio likely revealed myocardial injury and cardiac dysfunction.
Reconstruction of Coracoclavicular Ligament with Endobutton and Sutures to Stabilize Acromioclavicular Joint: A Retrospective Clinical Study and Finite Element Analysis
Authors: ding kai , zhang wen , chen xi , zhang yi-ge , ding wen ge 
Published: February 2021

Abstract
Acromioclavicular joint dislocation is a common sports injury disease, surgical treatment to restore the acromioclavicular joint stability, including stability and vertical stability level. However, vertical stability is often neglected. So we did a retrospective study enrolled 38 patients using Endobutton reconstruction and suture repair (Group A) with those using single Endobutton (Group B). The perioperative assessments contained coracoclavicular distance (CCD), Constant-Murley shoulder joint score, University of California at Los Angeles (UCLA) shoulder joint score and the difference between bilateral CCD 12 months postoperatively. The evaluation of group A was significantly better than group B. Constant-Murley scores and UCLA shoulder scores preoperatively were significantly higher than those after operation. The postoperative CCD of the two groups was lower than that before surgery. CCD between the affected shoulder and another postoperatively was no difference in group A, but was different in group B. The difference of postoperative CCD of the two groups was different. Afterward, we evaluated the stress and deformation around the acromioclavicular joint by finite element analysis and found that the stress dispersion and displacement reduction enhanced the stability of acromioclavicular joint. Thus, reconstruction of coracoclavicular ligament with Endobutton and sutures repair can increase the stability of acromioclavicular joint.
Postoperative Outcomes of Single-Stage Versus Staged Bilateral Rotator Cuff Repair in Patients with Bilateral Rotator Cuff Tear: A Retrospective Study
Authors: Wang Chen , Yang Pu , Zhang Dongfang , Jeon In-Ho , Yu Tengbo , Zhang Yingze , Qi Chao 
Published: February 2021

Abstract
Background: In the present study, we aimed to compare the clinical outcomes of patients who underwent single-stage or staged bilateral arthroscopic rotator cuff repair.Methods: From March 2013 to May 2018, a retrospective review on all patients who underwent bilateral arthroscopic rotator cuff repair at our department was performed. There were 24 patients in the single-stage group and 27 patients in the staged group. The minimum follow-up period was 2 years. The visual analog scale (VAS), American Shoulder and Elbow Surgeons (ASES) score, University of California, Los Angeles (UCLA) score, Constant-Murley (Constant) score, and the range of motion (ROM) of the shoulder were evaluated for comparison between the two groups before and after the operation. Moreover, the hospitalization costs in the two groups were also recorded.Results: All 51 patients were available throughout follow-up. There was no significant difference in the VAS score (P=0.424), ASES score (P=0.325), UCLA score (P=0.170), and Constant score (P=0.275) between the single-stage group and the staged group before the operation. Postoperative clinical scores were significantly improved in both groups. The VAS score, ASES score, UCLA score, and Constant score were significantly different between the two groups at 6 months postoperatively (P<0.05). At 12, 18, and 24 months after the operation, the VAS score, UCLA score, Constant score, and ASES score were not significantly different between the two groups. At follow-up, the ROM of the shoulder was not significantly different between the two groups. Besides, there was a significant difference in hospitalization costs between the two groups (P<0.05). Furthermore, there was no significant difference in the VAS score, UCLA score, Constant score, ASES score, and ROM between the first surgery and second surgery in the single-stage group postoperatively.Conclusion: Patients receiving single-stage or staged bilateral arthroscopic rotator cuff repair showed similarly good clinical outcomes at follow-up. Moreover, good outcomes were observed on both sides of the single-stage group.
A Comparative Study of Anxiety in Indonesia and Nepal During COVID-19 Pandemic
Authors: Jung Yeseul , Palutturii Sukri , Shin Dong Eun , Nam Eun Woo 
Published: February 2021

Abstract
Background: Indonesia and Nepal, which are in the World Health Organization South-East Asia Region, are the countries with the highest numbers of confirmed cases and deaths since the start of the COVID-19 pandemic outside of the Region of the Americas and the European Region. Since its first confirmed case on March 2nd, Indonesia has reported 100,303 cases and 4,838 deaths as of July 28, which is the highest number of cases in Southeast Asia. As restrictions in response to the pandemic continue, the public’s psychological anxiety is gradually increasing. Methods: There were 889 participants (university students and graduate students) living in Indonesia or Nepal (Indonesia: 551 persons; Nepal: 338 persons). An English questionnaire was administered to participants through an online survey using Google. T-test, Chi-squared test and logistic regression analysis were conducted.Results: Regarding the factors affecting anxiety, they were “trust in hospitals for COVID-19 diagnosis,” “risk of getting infected by COVID-19,” “risk of family getting infected by COVID-19,” “national discrimination due to COVID-19,” “chronic disease status,” “experience of purchasing masks,” and “health behaviors” in Indonesia, and “trust in hospitals for COVID-19 diagnosis,” “risk of family getting infected by COVID-19,” and “depression score” in Nepal. In both countries, significant effects of “trust in hospitals for COVID-19 diagnosis” and “risk of family getting infected by COVID-19” were observed.Conclusions: Therefore, Indonesia and Nepal should implement policies and guidelines to prevent psychological and psychiatric issues in the population due to the COVID-19 pandemic. Such measures will help to prevent and control the secondary damage caused by the disease.
Use of AXL-specific CAR T cells to treat non-small-cell lung cancer
Authors: Zhang Zhenfeng , Cao Bihui , Liu Manting , Zhou Yubo , Zhao Qi , Wang Lu , Liang Baoxia , Zhang Jinling , Li Junping , Chen Xiaopei , Feng Yunfei , Zhi Cheng , Yang Xin , Tian Yu , Hu Yuling , He Jinping , Hu Hong , Ye Xiaodie , Zhou Guo , Chen Aiming , Wu Qingde , Xu Linfeng , Zhao Ming , Lian Hui , Chen Deji , Yang Lili 
Published: February 2021

Abstract
The application of Chimeric antigen receptor (CAR) T cells in solid tumors is hindered by lack of tumor specific targets and inefficient T cell infiltration in tumor. It has been postulated that AXL may be an ideal immunotherapy target for non-small-cell lung cancer (NSCLC). Here, we screened 208 non-tumor samples from 22 types of human organs or tissues and 90 tumor samples from NSCLC patients by immunohistochemistry or Western Blotting and identified that AXL was rarely expressed in normal tissues but highly expressed in 69% NSCLC samples, suggesting AXL is an ideal target for CAR T cell therapy for lung cancer. We generated low-, mediate-, high-affinity AXL-CARs and evaluated their killing effect on NSCLC. Our data demonstrated antitumor effects of AXL-CAR T cell therapy for various NSCLC models both in vitro and in vivo. AXL-CAR T cells alone exerted strong antitumor effect in subcutaneous lung cancer cell derived xenograft (CDX), pulmonary metastases CDX, and intraperitoneal CDX models. Intraperitoneal delivery of CAR T cells resulted in superior tumor killing effects compared with systemic infusions for the intraperitoneal CDX tumor models. AXL-CAR T combined with microwave ablation (MWA) or EGFR-TKI resulted in enhanced killing effect and CAR-T cell infiltration in vivo. Together, our current study suggests that systemic or regional infusion of AXL-CAR T cell alone or combination with other therapies might have potential translatable value for the treatment of NSCLC in clinical situation.
Primary pelvic exenteration for locally advanced pelvic malignancies
Authors: GHEORGHE MIHAI , KISS SZILARD LEO , STANCA MIHAI , BOBES RADU FLORIAN , COZLEA ALEXANDRA LAVINIA , CAPÎLNA MIHAI EMIL , MOLDOVAN ANDREEA ANAMARIA 
Published: February 2021

Abstract
Background: Pelvic exenteration can be performed in selected patients with large pelvic malignancies as a primary treatment with curative intention. This study aimed to share our experience of primary pelvic exenterations, which were performed in a single institution between November 2011 and July 2020, enroling 23 patients with different types of pelvic cancers.Results: The patients mean age was 55 years (range: 43-72 years) and the oncological indications were: stage IVa cervical cancer (11 cases, 48.9%), stage IVa endometrial cancer (1 case, 4.3 %), stage IVa vaginal cancer (6 cases, 26%), stage IIIb bladder cancer (3 cases, 13%), stage IIIc rectal cancer (1 case, 4.3%) and undifferentiated pelvic sarcoma (1 case, 4.3%). Total, anterior, and posterior pelvic exenterations have consisted of 34.4%, 56.5% and 13% of cases, respectively. Related to levator ani muscle, 13 (56.5%) pelvic exenterations were supralevatorian, 10(43.5%) infralevatorian, and 5 (21.7%) were infralevatorian with vulvectomy. No major intraoperative complications have occured. Seven patients (30.5%) have developed early complications, and 4 of them (17.4%) have required reoperation. One (4.3 %) perioperative death caused by a pulmonary embolism was recorded and one patient had a late complication represented by a urostomy stenosis. Over a median follow-up period of 35 months, 8 (34.8%) patients have died. The median overall survival (OS) was 33 months (range 1-96 months). The 2-year and 5-year survival rates were 72% and 66% respectively. Univariate analysis showed that margin status was the only factor significantly associated with disease-free survival (DFS) (p=0.016). Conclusion: Primary pelvic exenteration can be related with various postoperative complications, without high perioperative morality and with long-term survival.
Microclimate effect on floating solar power plant production
Authors: Karatas Yalcin , Yilmaz Deniz 
Published: February 2021

Abstract
Solar power plants established are mainly built on uncultivated lands. However, the increase in land values due to the increasing population of the countries, the lack of necessary areas for these power plants in countries with small areas and the increasing need for energy have led to different pursuits. Installing photovoltaic systems on water resources appears as a good alternative solution in this regard. In this study, by using photovoltaic panels with an output power of 260 Wp and having a polycrystalline cell structure, a floating solar power plant with an output power of 120 kWp was installed on Buyukcekmece Lake, and the effect of the region's microclimate data on electricity generation was investigated. While the most important factor that positively affects power generation is radiation, it has been observed that the important environmental factors that affect negatively are specific humidity, wave strength and module temperature.
Prevalence of Urogenital Schistosomiasis and Water, Sanitation and Hygiene Risk factors for transmission among Primary School Children in an urban endemic area of Kinondoni Municipality in Dar es Salaam, Tanzania
Authors: Yangaza Yonah , Mushi Vivian , Zacharia Abdallah 
Published: February 2021

Abstract
Objectives: To determine the prevalence of urogenital schistosomiasis and water, sanitation, and hygiene risk factors for transmission among primary school children in an urban endemic area of Kinondoni Municipality in Dar es Salaam, Tanzania. Methods: A quantitative cross-sectional study was conducted between June and August 2020 to determine the prevalence of S.haematobium. A total of 250 urine samples were collected from primary school children, examined for haematuria using urinalysis test strips, and S.haematobium infection and intensity using the urine filtration technique. A structured questionnaire was used to collect information on water, sanitation, and hygiene risk factors that could influence the transmission of urogenital schistosomiasis. Data were entered and analyzed using SPSS version 22.Results: Out of 250 primary school children recruited, 13(5.2%) had haematuria, 3(1.2%) had S.haematobium ova, and all were light-intensity infections. Among the risk factor assessed the following were significantly associated with the transmission of urogenital schistosomiasis; type of latrine used at home (p=0.044), frequency of swimming (p=0.030), the children who never swallowed praziquantel (p<0.00), experienced side effects (p<0.00), type of side effects experienced (p=0.037), and reasons for not taking praziquantel in the last round of mass drug administration (p=0.007).Conclusions: The low prevalence of urogenital schistosomiasis indicates the ongoing transmission of the disease among primary school children. Frequency of swimming, type of latrines used at home, and non-uptake of praziquantel are the risk factors for the infection among primary school children. Therefore there is a need to provide health education to promote the uptake of praziquantel.
A Water Cycle-based Error Minimization Technique in Predicting Bearing Capacity of Foundation
Authors: Moayedi Hossein , Mosavi Amir 
Published: February 2021

Abstract
Selecting the appropriate training technique is a significant step in utilizing intelligent approaches. It becomes even more important when it comes to critical problems like analyzing the bearing capacity of foundations. This study investigates the feasibility of a capable metaheuristic algorithm, called water cycle algorithm (WCA), for training a multi-layer perceptron (MLP). The WCA-MLP is applied to a large finite element dataset to predict the settlement. The results of this model are compared with electromagnetic field optimization (EFO) and shuffled complex evolution (SCE) benchmarks. With reference to the obtained Pearson correlation factors (larger than 0.88 in all stages), all employed models are suitable for the mentioned objective. Moreover, it was observed that the training error of the WCA was 5.84 and 3.89% smaller than the EFO and SCE, respectively. Likewise, the accuracy of the WCA-MLP was 1.85 and 2.04% larger in the testing phase. Also, a predictive equation is finally elicited for practical applications in compatible circumstances.
What fuels the fire? Cooking fuel estimates at global, regional and country level for 1990-2030
Authors: Stoner Oliver , Lewis Jessica , Martínez Itzel , Gumy Sophie , Economou Theo , Adair-Rohani Heather 
Published: February 2021

Abstract
Household air pollution generated from the use of polluting cooking fuels and technologies is a major source of disease and environmental degradation in low- and middle-income countries. Using a novel modelling approach, we provide global, regional and country estimates for 6 specific fuel categories (electricity, gaseous fuels, kerosene, biomass, charcoal, coal) and overall polluting/clean fuel use – from 1990-2020 and with urban/rural disaggregation. Model results show 53% of the global population relied on polluting cooking in 1990, dropping to 36% in 2020. In urban areas, gaseous fuels dominate, with a growing reliance on electricity; in rural populations, high levels of biomass use persist alongside increasing use of gaseous fuels. Future projections of observed trends suggest 31% will still lack access to clean cooking in 2030, and the Sub-Saharan African population relying on polluting fuels is on course to exceed 1 billion by 2025.
Evaluation of water resource carrying capacity of two typical cities in northern China
Authors: Qiu Qingtai , Liu Jia , Li Chuanzhe , Jiao Yufei , Yu Fuliang , Li Xinyi 
Published: February 2021

Abstract
Global climate change and human activities are increasingly affecting the regional water resource carrying capacity (WRCC). For sustainable development, an important social challenge is understanding the carrying level of regional water resources. In this study, to assess the WRCC status, we used a fuzzy comprehensive evaluation model and combined the natural and social attributes of WRCC. Moreover, from the three dimensions of support force subsystem, pressure force subsystem (PFS), and regulation force subsystem (RFS), 12 evaluation indicators were selected. Furthermore, using the fuzzy comprehensive theory and natural and social comprehensive indicators, we constructed a WRCC-level evaluation model and used it to evaluate the carrying level of two typical cities in China, Shijiazhuang and Langfang, for the 2006–2015 period. The results demonstrate that the regional water-carrying status of each of these cities is slightly above that of WRCC and that carrying levels show an interannual increasing trend. Note that, in both cities, the primary reason for the low regional WRCC is water shortage, while PFS improvement, supported by an interannual PFS increasing trend during the same time period, is the primary reason for carrying-level improvement for both cities in the past 10 years. For the RFS dimension, evaluation scores were in the range of 2.14–2.98 for Shijiazhuang and 2.12–2.79 for Langfang. Furthermore, the evaluation model and the indicator system demonstrated complementary functionality; thus, our results have an important academic value, particularly with reference to evaluating the WRCC.