bluuebunny/crossref_metadata_2025_split huggingface dataset:
Needle Stick Injury by Aqueous Humor of a 31 Year Old PCR-Positive HIV Patient, a Case Report
Authors: Sefidan Bahram Bohrani , Sanij Amin Dehghani 
Published: August 2021

Abstract
Background Health worker Needle-stick injury (NSI) by internal body fluids can transmit serious pathogens like HIV. Considering Principles of personal and occupational care, plays an important role in prevention of such events. Case presentation A health worker suffered needle stick injury by aqueous humor of a PCR-positive HIV patient while he was recapping needle despite necessary preparations. Conclusions NSI by Aqueous humor which is secreted from blood, can theoretically transmit blood borne pathogens like HIV. Nevertheless, there is neither any report of aqueous humor NSI nor HIV transmission in this way. Based on our best knowledge this case is the first report represents HIV+ aqueous humor NSI and further evidence is required. Considering literature, we can not conclude whether there was a need for PEP in our case.
Optimum Dose of Spinal Ropivacaine with or Without Single Intravenous Bolus of S-Ketamine During Elective Cesarean Delivery: A Randomized, Sequential Dose-Finding Study
Authors: Zhang Xiaoyu , Wang Jianwei , An Xiao-Hu , Chao Yu-Chieh , Bian Yong , Xu Zifeng , Xu Tao 
Published: August 2021

Abstract
Background

Post-spinal hypotension has a high occurrence during cesarean delivery, and can lead to adverse maternal or fetal outcomes. The purpose of the study was to determine the optimal dose of spinal ropivacaine for cesarean section with or without intravenous single bolus of S-ketamine and to observe the incidences of hypotension of both methods.
Methods

Eighty women undergoing elective cesarean delivery were randomly allocated into Group ropivacaine or Group ropivacaine with intravenous S-ketamine. If the upper sensory level of the patient reached T6 and the visual analogue scale (VAS) scores continuously below 3 before delivery, the next patient had a 1/9th chance of receiving a lower dose or an 8/9th chance of receiving the same of previous dose. If the patient had VAS scores above 2 or needed an extra epidural rescue bolus before delivery, a higher dose was used for the next patient. The primary outcome was the successful use of spinal ropivacaine to maintain VAS of patients below 3 before delivery and the incidence of post-spinal hypotension of both groups. Secondary outcomes included the incidences of hypotension related symptoms and managements, upper sensory level of anesthesia, level of sedation, neonatal outcomes, Edinburgh postnatal depression scale scores on admission and discharging of hospital and post-operative analgesic effect. The 90% effective dose (ED90) and 95% confidence interval (95% CI) were estimated by isotonic regression.
Results

The estimated ED90 of ropivacaine was 11.8 mg (95% CI 11.7–12.7) with and 14.7 mg (95% CI 14.6–16.0) without intravenous S-ketamine using biased coin up-down sequential dose-finding method, and the incidences of hypotension and its related symptoms were significantly lower in S-ketamine group.
Conclusions

A spinal dose of ropivacaine 12 mg with single intravenous 0.15 mg/kg bolus dose of S-ketamine may significantly reduce the risk of hypotension and provide sedative status before delivery, thus the method could be cautiously used in parturients with high risks of hypotension or extreme nervousness.
Clinical trial registration:
http://www.chictr.org.cn (ChiCTR2000040375; 28 Nov 2020)
Dimethylaminomicheliolide (DMAMCL) Inhibits Cell Proliferation and Increases Apoptosis and Efficacy of Gemcitabine via Annexin A2 in Pancreatic Adenocarcinoma
Authors: Liu Kaihui , Guo Jianshuang , Liu Ning , Wang Jiyan , Wang Mukuo , Zhang Yanwei , Jiang Hao , Liu Yanling , Hu Fangzhong , Fu Wenzheng , Zhang Chunze , Li Lianyong , Zhang Mengyi , Li Jing 
Published: August 2021

Abstract
Background: Pancreatic adenocarcinoma is one of the highest malignant tumors in digestive tract with extremely poor survival rate. Dimethylaminomicheliolide (DMAMCL) is a clinical developing anti-cancer agent, however, little is known regarding its effects in pancreatic cancer, and the mechanisms of DMAMCL are still not fully understood.Methods: This study evaluated DMAMCL on three pancreatic cancer cell lines by cell viability assay, colony formation assay, and apoptosis assay. To identify the direct binding target of DMAMCL in pancreatic cells, a chemical proteomics approach, molecular docking and site-directed mutagenesis were performed.Results: DMAMCL inhibits proliferation and promotes apoptosis of pancreatic cancer cells. Interestingly, using a chemical proteomics approach, we identify ANXA2 as a direct binding target of DMAMCL in pancreatic cells. Molecular docking and site-directed mutagenesis confirm that Cys132 (C132) of ANXA2 is the binding site for DMAMCL. The knockdown of ANXA2 largely decreases the inhibition activity of DMAMCL, indicating that the effect of DMAMCL is mainly mediated by ANXA2 in pancreatic cancer. In addition, the combination regimen of gemcitabine and DMAMCL exhibits synergistic effect on pancreatic cancer cell lines at both proliferation and pro-apoptosis level. Conclusions: Thus, our findings elucidate the mechanisms of DMAMCL and may provide a potential strategy to enhancing the efficacy of gemcitabine in pancreatic adenocarcinoma.
Upgrading Information Security and Protection for Palm-Print Templates
Authors: Poonia Poonam , Ajmera Pawan K. 
Published: August 2021

Abstract
Biometric systems proven to be one of the most reliable and robust method for human identification. Integration of biometrics among the standard of living provokes the necessity to vogue secure authentication systems. The use of palm-prints for user access and authentication has increased in the last decade. To give the essential security and protection benefits, conventional neural networks (CNNs) has been bestowed during this work. The combined CNN and feature transform structure is employed for mapping palm-prints to random base-n codes. Further, secure hash algorithm (SHA-3) is used to generate secure palm-print templates. The proficiency of the proposed approach has been tested on PolyU, CASIA and IIT-Delhi palm-print datasets. The best recognition performance in terms of Equal Error Rate (EER) of 0.62% and Genuine Acceptance Rate (GAR) of 99.05% was achieved on PolyU database.
Challenges in delivering Chinese Standardized Resident Doctor Training – Experience and Innovation of a young Chinese hospital
Authors: Liu Ming-Ya , Luo Ming-Juan , Pai Pearl 
Published: August 2021

Abstract
BackgroundIt has been almost a decade since the introduction and implementation of the Chinese National Standardized Resident Training Program nationwide but variations of training quality and the result of the training remain wide among different training bases and regions. Many of the younger training institutions are facing serious challenge in recruiting, keeping and inspiring trainers and trainees, thereby achieving a viable and competent training program.MethodsWe describe below how we as a young Chinese 3A hospital and training base recruit and inspire our trainees to develop themselves into highly professional and competent doctors. We shall also describe some of the training supervisions and methods we have used in our program, to enable our trainees and young training doctors to achieve these aspirations.ResultsBy striking a balance of conventional teaching methods and innovative methods, we are able to inspire trainees to develop a greater understanding of ethics, humanity, dialogue, and team work as well as knowledge and skill. The teaching standard of our young training doctors also improved along the way.ConclusionsIn our limited experience, it would appear that trainees showed more interest and willingness to participate actively in workshop, role play and team work than conventional passive didactic lectures, given the training opportunity. Good supervised training and constructive feedback are indispensable elements for the development of both trainees and young training teachers in a successful training program. Trial registration: not applicable
Type2 IFC with SOA for Topic Detection and Document Clustering Analysis
Authors: P Perumal , B Mathivanan 
Published: August 2021

Abstract
The automatic document clustering and topic extraction from the corpus provides a very essential requirement in many real time applications. The document clustering and topic detection is utilized to locating data quickly. Hence, in this paper, Type 2 Intuitionistic Fuzzy Clustering and Seagull Optimization Algorithm (Type 2 IFCSOA) is developed for document clustering and topic detection. The Type 2 IFCSOA is utilized to cluster the documents. Additionally, ensemble approach is utilized to identify by the topics from the clustered documents. In the proposed methodology, the pre-processing is utilized to remove unwanted information from the documents such as tokenization, stop word removal and stemming process. After that, the proposed method is utilized to cluster the documents. The clustered documents are labeled with the basis of clusters. After that, to achieve topic detection, the ensemble approach is utilized with feature extraction phases such as Term Frequency- Inverse Document Frequency (TF-IDF), Mutual information (MI), Text Rank Algorithm and analysis of keyword taking out from co-occurrence statistical -Information (CSI). The proposed methodology is implemented in MATLAB and performances were evaluated with the statistical measurements such as precision, recall, accuracy, sensitivity, purity measure and entropy. The proposed method is compared with the conventional methods such as Fuzzy C Means clustering (FCM), FCM-Particle Swarm Optimization (PSO), FCM-Genetic Algorithm (GA) and K means clustering.
The Role of the Church in Motivating Entrepreneurship in Efforts to Improve the Economy of Indigenous Peoples in Papua, Indonesia
Authors: Utama I Gusti Bagus Rai , Junaedi I Wayan Ruspendi , Waruwu Dermawan , Damayana I Wayan , Utama I Gusti Bagus Rai 
Published: August 2021

Abstract
The novelty of this research is to prove that the church has not been able to encourage and motivate the growth of entrepreneurship to improve the economy of indigenous peoples in Papua. This research was conducted in-depth using descriptive qualitative methods. The location of the research was carried out in Papua with in-depth interviews, observation, and secondary data techniques. The results of the study indicate that the efforts of the Indonesian Christian Church in Papua in improving the economy of indigenous peoples are still minimal, both at the synod, classic and congregational levels. The church is currently also experiencing quite heavy challenges internally and externally, especially with the global Covid-19 pandemic situation which severely limits the movement of people in their activities. In some areas in Papua, there are still problems with the internet network which makes communication even more difficult. To improve the economy of indigenous peoples, an appropriate customary empowerment strategy is needed and strategic steps are needed, namely an open heart-to-heart dialogue by all church components internally at various levels. A concrete problem mapping is required, with a scale of priorities and the ability to implement strategic indigenous economic development programs and supported by appropriate assistance according to the regional or customary context. Along with that, the church must prepare competent human resources in their fields for the benefit of long-term economic development.
Delayed Cerebellar Injury is Affected by Multiple Organ Dysfunction Syndrome Caused by Heat Stroke, a Retrospective Cohort Study
Authors: Ni Xiao-xiao , Wang Cong-lin , Wang Jie , Guo Ye-qun , Chen Yan , Zheng Bo , Yu Rong-hao , Liu Zhifeng 
Published: August 2021

Abstract
Objective Nervous dysfunction is the main manifestation of heat stroke (HS). Here we investigated the clinical signs for HS-induced nerve injuries. Methods Retrospective data were collected on 119 patients who got HS from 2016 to 2020. Patients were divided into 4 groups, including the cerebellar injury group, the other nerve injuries group, non-cerebellar injury group and non-nerve injury group. The age, body temperature (Tc), degree of consciousness disorder, liver and kidney function, blood coagulation function, blood routine and cardiac indicators within 24 h after HS were summarized. Moreover, we performed regression analyses to identify risk factors for nervous dysfunction. The Activity of Daily Living (ADL) score was assessed 3 months after HS to evaluate the prognosis of HS. Results Compared with other groups, the cerebellar injury group had shorter Tc recovering time, lower GSC scales, longer coma time and more hypotension, gastrointestinal bleeding, multiple organ dysfunction syndrome (MODS) and metabolic acidosis significantly. The cerebellar injury group had higher myocardial enzymogram and indexes of liver and kidney dysfunction, immune and coagulation dysfunction significantly. Risk factors associated with HS-induced cerebellar injury are Tc, recovery time of Tc, NSE, GCS scale, lymphocyte count, HLA-DR/CD14, coagulation dysfunction, cardiac injury, metabolic acidosis and MODS. The ADL scale of the cerebellar injury group and the other nerve injury group were significantly lower than other groups. Conclusions Patients with severe coma and MODS are more prone to cerebellar injury after HS and the HS-induced nerve injury leaded to a worse prognosis.
Morphometric Evaluation of Facial and Vestibulocochlear Nerves Using Magnetic Resonance Imaging in Patients with Menière’s Disease
Authors: Flatz Wilhelm , Henneberger Annika , Gürkov Robert , Schinner Regina , Mueller-Lisse Ullrich , Reiser Maximilian , Ertl-Wagner Birgit 
Published: August 2021

Abstract
Several studies proposed a loss of neural structures (such as hair cells or neurons within the spiral ganglion) in Menière’s disease (MD). It has been shown that VIIth and VIIIth cranial nerves are enlarged within MD patients compared to normal controls. We now aimed to investigate potential differences in these two nerves in patients with MD. Etiology of endolymphatic hydrops, central pathological hallmark of MD, includes genetic predisposition, autoimmune processes, viral infections, cellular apoptosis and oxidative stress. We evaluated morphometric properties (long and short diameter, cross-sectional area) of the VIIth and VIIIth cranial nerves passing from the cerebellopontine angle to the inner ear modiolus, acquired on a clinical 3T magnetic resonance imaging scanner. 71 patients with MD were included, 53 of whom clinically showed a unilateral affection. Our data showed no differences in nerve morphometry between the clinically non-affected and the clinically affected side in patients with clinically unilateral MD. There was also no correlation to duration of symptoms, in contrast to previously demonstrated correlations between clinical features and the extent of endolymphatic hydrops. A disease process starting before the onset of clinical symptoms could be a potential explanation.
Identification of Prognostic Immune-Related lncRNAs Pairs in Immune Infiltration of Breast Cancer
Authors: Xu Qianhui , Chen Shaohuai , Hu Yuanbo , Huang Wen 
Published: August 2021

Abstract
Background: Accumulating evidence has supported that long non-coding ribonucleic acids (lncRNAs) could act as essential regulators in cancer immunity. An immune-related lncRNAs (irlncRNAs) risk signature without specific expression value was established to accurately predict prognosis in patients with breast cancer (BRCA).Methods: First, irlncRNAs were identified using co-expression analysis and differential expressed irlncRNAs (DEirlncRNAs) were recognized by “Limma” package. Then, DEirlncRNA pairs were determined using an iteration loop and a 0-or-1 screening matrix. Next, single factor test and Lasso algorithm followed by multivariate Cox regression were employed to establish risk signature. Besides, the Akaike information criterion (AIC) values were calculated to recognize the optimal cut-off point of low- or high-risk groups. Additionally, the potential role of risk score was explored in terms of overall survival, clinical variables, tumor immune microenvironment features, immunotherapeutic targets, and TMB (tumor mutation board) statues.Results: A total of 946 irlncRNAs were determined and 188 DEirlncRNAs were identified. 15 DEirlncRNA pairs were introduced into establishment of prognostic signature, which harbored powerful and independent predictive prognostic ability. Taking advantage of AIC values, risk model was demonstrated to accurately distinguish samples from the viewpoint of clinical outcome, clinicopathological features, infiltrating immune cells, and immunosuppressive biomarkers. Besides, comprehensive prognostic nomogram was constructed to quantitatively estimate risk. Finally, synergistic effect of risk score with TMB value was corroborated.Conclusions: The DEirlncRNA pairs risk signature without specific expression value possessed excellent prognostic performance and may provide direction for immunotherapy in BRCA.
CFD and Laboratory Studies of Dust Cleaning Efficacy of an Efficient Four Stage Non-Clogging Impingement Filter for Flooded-Bed Dust Scrubbers
Authors: Kumar Ashish Ranjan , Gupta Neeraj , Schafrik Steven 
Published: August 2021

Abstract
Fibrous-type filters are used to capture dust particles in mining and other occupations where personnel are exposed for prolonged periods. Dust cleansing systems including flooded-bed dust scrubbers use these mesh-type multi-layered filters. These filters trap dust particles efficiently on their surface and inside their mesh. However, their continued operation leads to dust build-up and subsequent clogging. This results in increased resistance of the filter and lowered airflow rate through the scrubber. This could potentially enhance the exposure of the miners. A non-clogging self-cleaning impingement screen type dust filter was designed by the authors for use in mining and industrial dust cleansing applications. The filter guides dirt-laden air through rapidly turning paths which forces it to shed heavier particles. The particles impact one of the impermeable solid metallic filter surfaces and are removed from the airstream. A full cone water spray installed upstream prevents any surface build-up of dust. This paper summaries the computer models generated to show the filter operations and laboratory experiments including optical particle counting to establish the cleaning efficiency.
Ratiometric Probe for Rapid Naked Eye Detection of Toxic Hydrazine: Real Time Application in Strip Test, Spray Test and Soil Analysis
Authors: Vijay Natarajan , Velmathi Sivan 
Published: August 2021

Abstract
Striking colorimetric probe (CynH) for abrupt detection of hydrazine under complete aqueous solution was achieved. The water soluble probe was designed with electron “push-pull” strategy by coupling of 4-hydroxy benzaldehyde and 2, 3, 3-trimethylindolinine. The positively charged N-propylated indolinine make the probe completely soluble in water. The probe yields eye catching selective detection of hydrazine over other competing analytes with high sensitivity. Obvious colour change was observed from colourless to appearance of bright pink colour with hydrazine. It reacts quickly with hydrazine within 2 minutes and makes the probe an effective candidate for practical application. The real time application was demonstrated using paper strip to detect hydrazine vapour. This probe is superior to earlier reported probes because of its effective sensing of hydrazine displayed with various applications including real-time strip based sensing, spray test and soil analysis. In all the examinations, the probe yields distinct response with rapid naked eye colour change this overcomes the drawbacks of previous reports.
Analysis of the Fluid Contents of Simple Bone Cyst in the Mandible: Blood or Serum?
Authors: Choi So-Young , Boboeva Obida , Ham Ji Yeon , An Chang-Hyeon , Lee Sung Tak , Kim Jin-Wook , An Seo-Young 
Published: August 2021

Abstract
Description of the content of simple bone cyst (SBC) has been controversial. This study aimed to evaluate and give a clearer picture of the contents of the SBC cavity. Nineteen patients SBC confirmed by histopathological examination, between 2014 and 2016, were included in this study. The clinical, radiographic, surgical and laboratory findings of SBC cavity content was analyzed. For statistical analysis, paired samples t-test was used to evaluate the difference of components among cavity fluid, blood and serum. All 19 SBC cases radiographically and surgically revealed a fluid-filled cavity. The average age of the patients was 21.3±13.2 years. Any sex predominance was not found. SBCs were more often found in the anterior mandible site (n=12, 63.2%). All lesions were filled with clear straw-colored or low concentrated blood-colored flood. Although the laboratory analysis of the fluid showed components similar to those in blood and serum, the statistical analysis showed that the fluid components were not significantly different only for eosinophils (p = 0.43) and basophils (p = 0.06) counts as blood components, and sodium (p = 0.76), potassium (p = 0.08) and chloride (p = 0.13) concentration as serum components. Within a limitation of this study, the results shows that SBC is fluid-filled cavity and the cavity fluid is more likely similar to the serum rather than the blood regarding the internal components.
Strokes Following Attempted Suicide: Frequency, Mechanisms, Outcome and Review of the Literature
Authors: Silva Mauro , Michaud Laurent , Correia Pamela , Nishida Masaki , Michel Patrik 
Published: August 2021

Abstract
Background: Only a few patients with strokes following suicide attempt (SFSA) are described in the literature and dissection of cervical arteries is the best-known mechanism. We aimed to determine the frequency, clinical presentation, mechanisms and outcomes of such patients by systematic observation in a single academic institution.Method: We retrospectively identified in our acute ischemic stroke registry all SFSA over 11 years. A thorough work-up was performed to establish the stroke mechanism. We also searched all published SFSA in the world literature for further analysis of demographics, comorbidities and long-term outcome. Results: Work-up showed multiple stroke mechanisms as well as multiple psychiatric. After adding 7 already published SFSA and comparing all SFSA with our stroke registry, SFSA were younger, had similar stroke severity, higher early mortality, and similar long-term functional outcome.Conclusions: SFSA is rare, affects younger patients and may be missed without an appropriate level of suspicion and neuroimaging. Long-term outcome seems comparable to other stroke patients despite an increased early mortality.