bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Risk of Dementia in Adults with Abdominal Aortic Aneurysm
Authors: Cho Hyung-jin , Yoo Ju-hwan , Kim Mi-hyeong , Ko Kyung-jai , Jun Kang-woong , Han Kyung-do , Hwang Jeong-kye 
Published: September 2021

Abstract
Background Abdominal aortic aneurysm (AAA) and dementia have similar epidemiological profiles and common pathogenic mechanisms. However, there have been few studies on the link between these two diseases.Materials and methods For this study, information from 2009 to 2015 was extracted from the Korean National Health Insurance system database. A total of 15,251 participants with a new diagnosis of AAA was included. Propensity score matching by age and sex with patients in whom AAA was not diagnosed was used to select the control group of 45,753 participants. The primary endpoint of this study was newly diagnosed dementia (Alzheimer’s disease (AD), vascular dementia (VD), or other type of dementia). ResultsThe incidence of dementia was 23.084 per 1000 person years in the AAA group, which was higher than that of the control group (15.438 per 1000 person years). When divided into AD and VD groups, the incidence of AD was higher than that of VD, but the HR of AAA for occurrence of dementia was higher in VD (1.382 vs. 1.784). Among the various risk factors, there was an interaction if age, hypertension, and history of cardiovascular disease with incidence of dementia (p < 0.05). In the presence of hypertension, the HR for occurrence of dementia was high according to presence or absence of AAA (1.474 vs 1.165). In addition, this study showed higher HR in the younger age group (age < 65) and in the group with no history of cardiovascular disease [1.659 vs. 1.403 (age), 1.521 vs. 1.255 (history of cardiovascular disease)].Conclusions AAA was associated with increased risk of dementia regardless of AD or VD, even after adjusting for several comorbidities. These findings indicate that follow-up with AAA patients is necessary for early detection of signs and symptoms of dementia.
Gelatinase-Sensitive Nanoparticles Loaded with Photosensitizer and STAT3 Inhibitor for Cancer Photothermal Therapy and Immunotherapy
Authors: Bu Lin-Lin , Wang Han-Qi , Pan Yuan-Wei , Chen Lei , Wu Hao , Wu Xian-Jia , Zhao Chen-Chen , Rao Lang , Liu Bing , Sun Zhi-Jun 
Published: September 2021

Abstract
Matrix metalloproteinases (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the metastatic of tumor cells, and have been associated with poor outcome of head and neck squamous cell carcinomas (HNSCCs). In the present work, MMPs-degradable gelatin nanoparticles (GNPs) are simultaneously loaded with photosensitizer indocyanine green (ICG) along with signal transducer activator of transcription 3 (STAT3) inhibitor NSC74859 (NSC, N) for efficient photothermal therapy (PTT) and immunotherapy of HNSCCs. In the tumor tissue, Gel-N-ICG was degraded and encapsulated ICG and NSC were effectively released. Under near-infrared (NIR) irradiation, the released ICG nanoparticles enabled effective photothermal destruction of tumors, and the STAT3 inhibitor NSC elicited potent antitumor immunity for enhanced cancer therapy. Based on two HNSCC mouse models, we demonstrated that Gel-N-ICG significantly delayed tumor growth without any appreciable body weight loss. Taken together, the strategy reported here may contribute that the proteases-trigger platform could reduce tumor size more effectively in complex tumor microenvironment (TME) through combination of PTT and immunotherapy.
Hypochromic Red Cells as Predictors of Anemia in Patients Undergoing Hemodialysis: An Observation Retrospective Study
Authors: Kee Youn Kyung , Jeon Hee Jung , Oh Jieun , Shin Dong Ho 
Published: September 2021

Abstract
The percentage of hypochromic red blood cells (%HRC) estimates the availability of iron by evaluating the degree of hemoglobinization. We investigated whether %HRC was a predictor of anemia in patients undergoing hemodialysis. We recruited 142 patients undergoing routine hemodialysis between 2017 and 2019. Delta hemoglobin level (ΔHb)1mo-baseline was calculated as the difference between the hemoglobin level at 1 month after study enrollment and that at study enrollment. Development of anemia was defined as hemoglobin level ≤15% of baseline. The median %HRC was 3.1%. There was a significant negative correlation between (ΔHb)1mo- baseline and %HRC (r = -0.63, P < 0.001). The incidence of anemia was significantly higher in patients with %HRC >3.1% than in those with %HRC ≤3.1%. In the multivariate logistic regression analysis, %HRC was significantly related to the development of anemia (odds ratio 2.57, 95% confidence interval [CI] 1.72–3.85, P < 0.001). The best cutoff value for %HRC to predict the development of anemia was 4.3%, with a sensitivity and specificity of 67.74 (95% CI, 54.7–79.1) and 97.50 (95% CI, 91.3– 99.7), respectively. %HRC is an independent predictor of anemia in patients undergoing hemodialysis. %HRC ≤4.3% is an early marker to consider changing the anemia treatment.
Race and Ethnic Group Dependent Space Radiation Cancer Risk Predictions
Authors: Cucinotta Francis A. , Saganti Premkumar B. 
Published: September 2021

Abstract
Future space missions by national space agencies and private industry, including space tourism, will include a diverse makeup of crewmembers with extensive variability in age, sex, and race or ethnic groups. The relative risk (RR) model is used to transfer epidemiology data between populations to estimate radiation risks. In the RR model cancer risk is assumed to be proportional to background cancer rates and limited by other causes of death, which are dependent on genetic, environmental and dietary factors that are population dependent. Here we apply the NSCR-2020 model to make the first predictions of age dependent space radiation cancer risks for several U.S. populations, which includes Asian-Pacific Islanders (API), Black, Hispanic (white and black), and White (non-Hispanic) populations. Results suggest that male API and Hispanic populations have the overall lowest cancer risks, while White females have the highest risk. Blacks have similar total cancer rates than Whites, however their reduced life expectancy leads to modestly lower lifetime radiation risks compared to Whites. There are diverse tissue specific cancer risk ranking across sex and race, which include sex specific organ risks, female’s having larger lung, stomach, and urinary-bladder radiation risks, and male’s having larger colon and brain risks.
Psychological Distress in Adolescents: Prevalence and its Relation to High Risk Behaviors Among Secondary School Students in Uganda.
Authors: Anyanwu Michael U. 
Published: September 2021

Abstract
BackgroundPsychological distress is a mental health condition that is common in adolescents. It negatively affects the academic performance of adolescents, relationships with family and friends, and the ability of adolescents to participate fully in the community. Stressful life events in low income countries and risk taking behavior of adolescents have raised concerns on the magnitude and impact of psychological distress among adolescents in Uganda. This study aims to estimate the prevalence of psychological distress and assess the high risk behaviors associated with psychological distress among secondary school students in Uganda. MethodsA community based cross-sectional study was conducted among secondary school students in Mbarara Municipality, Uganda. Multistage cluster sampling technique was used to recruit study participants and a total of 921 students participated in the study using a self-reported questionnaire. Psychological distress was assessed by Kessler’s psychological distress scale (K10). To identify high risk behaviors associated with psychological distress, multinomial logistic regression was used with p <0.05 and 95% confidence interval. ResultsThe prevalence of psychological distress was 57%. Risky sexual behavior, alcohol consumption, smoking and substance use were associated with psychological distress. Also, boarding school students, those in mixed schools, students that own mobile phones and adolescents with chronic illness were more likely to report psychological distress. ConclusionThe prevalence of psychological distress is high among school going adolescents and risky behaviors were associated with psychological distress. The findings suggest the need to address mental health issues in adolescents.
Prognostic Indicators of Yang’s Arthroscopic Technique for Management of Temporomandibular Joint Anterior Disc Displacement: Part 1- Clinical Predictors.
Authors: Sah Manoj Kumar , Abdelrehem Ahmed , Chen Shihui , Shen Pei , Jiao ZiXian , Hu Ying Kai , Yang Chi 
Published: September 2021

Abstract
In order to optimize the patient selection for specific treatment modality and to achieve favorable treatment outcomes, prognostic indicators impacting the results are important to analyze. This longitudinal retrospective study aimed to analyze various prognostic factors impacting the surgical outcomes following Yang’s arthroscopic discopexy for management of temporomandibular joint anterior disc displacement using success criteria based on pain, maximal interincisal opening, diet, and quality of life. Furthermore, a quantitative MRI assessment of disc position and condylar height was performed pre- and postoperatively. Multinomial analysis was used to evaluate various prognostic variables including gender, age, duration of illness, Wilkes staging, parafunctional habits, and splint/orthodontic therapy. A total of 169 patients (234 joints) were included. The outcome was categorized as excellent (n = 67/39.6%), good (n = 72/42.6%), improved (n = 22/13.01%) or poor (n = 8/4.73%) with a success rate of 95.26%. Patients aged from 11–15 years old were significantly more likely to be in the good outcome group (odds ratio (OR), 0.20; P < 0.05). Also, patients with shorter duration of illness (OR, 0.29; P < 0.05) and with Wilkes stage III (OR, 0.11; P < 0.05) were more likely to be in the improved outcome group. Better outcomes can be achieved at younger patients with shorter disease history and earlier Wilkes staging.
Comparative Transcriptome and Metabolome Analyses Reveal the Methanol Dissimilation Pathway of Pichia Pastoris
Authors: Yu Yi-fan , Yang Jiashuo , Zhao Fengguang , Lin Ying , Han Shuangyan 
Published: September 2021

Abstract
Background: Pichia pastoris (Komagataella phaffii) is a model organism widely used for the recombinant expression of eukaryotic proteins, and it can metabolize methanol as its sole carbon and energy source. Methanol is oxidized to formaldehyde by alcohol oxidase (AOX), which is further metabolized either in the assimilation or dissimilation pathway. In the dissimilation pathway, formaldehyde is oxidized to CO2 by formaldehyde dehydrogenase (FLD), S-hydroxymethyl glutathione hydrolase (FGH) and formate dehydrogenase (FDH). In addition, formaldehyde induces DNA-protein crosslinks (DPCs). Formaldehyde dehydrogenase is critical to minimize formaldehyde-mediated DNA lesions. Although phenotypes have been studied in engineered strains by modified dissimilation, there is a clear lack of systematic studies at the whole-omics level, especially transcriptomics and metabolomics.Results: Focusing on the dissimilation pathway being cut off, we compared the transcriptomes and metabolomes from a formaldehyde dehydrogenase-deficient strain (Δfld), an S-hydroxymethyl glutathione dehydrogenase-deficient strain (Δfgh), a formate dehydrogenase deficient-strain (Δfdh) and the wild type (GS115). First, the differences between strains were most apparent after FLD knockout. When methanol was used as the sole carbon source, the differential metabolites between GS115 and Δfld were mainly enriched in ABC transporters, amino acid biosynthesis, and protein digestion and absorption. Second, analysis of differentially expressed genes (DEGs) between knockout and wild type strains under methanolic incubation showed that oxidative phosphorylation, glycolysis and the TCA cycle were downregulated, while proteasomes, autophagy and peroxisomes were upregulated. Transcription of alcohol metabolism was upregulated. It is worth noting that the degree of variation was positively correlated with the gene order of dissimilation pathway knockdown. In addition, there were significant differences in amino acid metabolism and glutathione redox cycling that raised our concerns about formaldehyde sorption in cells.Conclusions: This is the first time that integrity of dissimilation pathway analysis was carried out in Pichia pastoris on the basis of transcriptomics and metabolomics. Truncation of the dissimilation pathway affected methanol metabolism, and knockdown of FLD impaired formaldehyde assimilation. The significant downregulation of oxidative phosphorylation may reveal that FLD and FGH are key enzymes in the energy utilization of cellular methanol metabolism. In addition, formaldehyde can not only bind glutathione but also react with amino acids, especially cysteine. The upregulation of the proteasome and autophagy may solve the problem of DNA-protein crosslinking caused by formaldehyde.
Diamondoids and Thiadiamondoids Generated From Hydrothermal Pyrolysis of Crude Oil and TSR Experiments
Authors: Peng Yanyan , Cai Chunfang , Fang Chenchen , Wu Liangliang , Liu Jinzhong , Sun Peng , Liu Dawei 
Published: September 2021

Abstract
Diamondoid compounds are widely used to reflect thermal maturation of high mature source rocks or oils and oil cracking extents. However, diamondoids and thiadiamondoids were demonstrated to have newly been generated and decomposed in our hydrothermal pyrolysis of crude oil and TSR experiments. Our results show that adamantanes and diamantanes are generated primarily within the maturity range 0.48–2.1% and 1.2–3.0% EasyRo, respectively. Their formation is enhanced and the decomposition of diamantanes obviously lags behind at elevated temperatures compared with anhydrous experiments. MDI, EAI, DMAI-1, DMDI-2 may serve as reliable maturity proxies at > ca.1.0% EasyRo, and other isomerization indices (TMAI-1, TMAI-2 and DMAI-2) are effective for the highly mature organic matter at EasyRo > 2.0%. The extent of oil cracking (EOC) calculated from the broadly used 3-+4-MD method (Dahl et al., 1999) is proven to overestimate, especially for highly cracked samples due to the new generation of 3-+4-MD. Still, it can be corrected using a new formula at <3.0% EasyRo. Other diamondoid-related indices (e.g. EAI, DMDI-2, As/Ds, MAs/MDs, DMAs/DMDs, and DMAs/MDs) can also be used to estimate EOC. However, these indices cannot be applied to TSR-altered petroleum. TSR is experimentally confirmed to generate diamantanes and thiaadmantanes at 1.81% EasyRo via direct reactions of reduced S species with hydrocarbons and accelerate the decomposition of diamantanes at > 3.0% EasyRo compared with thermal chemical alteration (TCA).
Comparison of radiomic pre-processing steps in the reproducible prediction of disease free survival across multi-scanners/centers
Authors: Ferreira Marta , Lovinfosse Pierre , Hermesse Johanne , Decuypere Marjolein , Rousseau Caroline , Lucia François , Schick Ulrike , Reinhold Caroline , Robin Philippe , Hatt Mathieu , Visvikis Dimitris , Bernard Claire , Leijenaar Ralph T.H. , Kridelka Frédéric , Lambin Philippe , Hustinx Roland , Meyer Patrick E. 
Published: September 2021

Abstract
Background

Features reproducibility and the generalizability of the models are currently among the most important limitations when integrating radiomics into the clinics. Radiomic features are sensitive to imaging acquisition protocols, reconstruction algorithms and parameters, as well as by the different steps of the usual radiomics workflow. We propose a framework for comparing the reproducibility of different pre-processing steps in PET/CT radiomic analysis in the prediction of disease free survival (DFS) across multi-scanners/centers.
Results

We evaluated and compared the prediction performance of several models that differ in i) the type of intensity discretization, ii) feature selection method, iii) features type i.e, original or tumour to liver ratio radiomic features (OR or TLR). We trained our models using data from one scanner/center and tested on two external scanner/centers. Our results show that there is a low reproducibility in predictions across scanners and discretization methods. Despite of this, TLR based models were generally more robust than OR. Maximum relevance minimum redundancy (MRMR) forward feature selection with Pearson correlation was the feature selection method that had the best mean area under the precision recall curve when using it combining the features from all discretization’s bin’s number (D_All_FBN) with TLR features for two of the four classifiers.
Conclusion

We evaluated and compared the prediction performance of several models in a data set containing hundred fifty-eight patients with locally advanced cervical cancer (LACC) from three distinct scanners. In our cohort of LAAC patients pre-processing of radiomic features in [18F]FDG PET affects DFS predictions performances across scanners and combining the D_All_FBN TLR approach with the MRMR forward Pearson feature selection method might help increasing robustness of radiomic studies.
Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest-derived multilineage cells
Authors: Abe Shigehiro , Kaida Atsushi , Nakazato Keiichiro , Yokomizo Naoko , Kobayashi Yutaka , Miura Masahiko , Miki Toshio , Hidai Chiaki , Kitano Hisataka , Yoda Tetsuya 
Published: September 2021

Abstract
Background
Although multilineage cells derived from oral tissue, especially the dental pulp, apical papilla, periodontal ligament, and oral mucosa, have neural crest-derived stem cell (NCSC)-like properties, the differences in the characteristics of these progenitor cell compartments remain unknown. The primary aim of the current study was to elucidate these differences.
Methods
Multilineage sphere-forming apical papilla-derived cells (APDCs), periodontal ligament-derived cells (PDLDCs), and oral mucosa stroma-derived cells (OMSDCs) from the same individuals were isolated from impacted developing teeth. All sphere-forming cells were characterized by biological analyses of stem cells. Additionally, composites of these cells and multiporous hydroxyapatite scaffolds were transplanted into immunocompromised mice.
Results
All sphere-forming cells expressed neural crest-related markers. Although APDCs and PDLDCs showed greater mineralized-cell differentiation, they exhibited poorer differentiation into adipocytes in vitro than OMSDCs. In immunocompromised mice, APDCs were better able to form hard tissues than PDLDCs and OMSDCs. Moreover, the expression of certain tissue-specific markers, such as CD24 and CD56 (NCAM1), differed among the tissue-derived cells. Surprisingly, the expression of only CD24 and CD56 could be discriminated among human tissues.
Conclusions
Our results suggest that although cells having NCSC-like properties present the same phenotype, they differ in the expression of certain markers and differentiation abilities. The present study is the first to demonstrate the differences in differentiation ability and molecular markers among multilineage human APDCs, PDLDCs, and OMSDCs obtained from the same patients and, concomitantly, the same sites and identify these tissue-specific markers in the human tooth developmental process.
Active Earth Pressure Against Flexible Retaining Wall For Finite Soils Under The Drum Deformation Mode
Authors: Weidong Hu , Xinnian Zhu , Yongqing Zeng , Liu Xiaohong , Chucai Peng 
Published: September 2021

Abstract
A reasonable method is proposed to calculate the active earth pressure of finite soils based on the drum deformation mode of the flexible retaining wall close to the basement’s outer wall. The flexible retaining wall with cohesionless sand is studied, and the ultimate failure angle of finite soils close to the basement’s outer wall is obtained using the Coulomb theory. Soil arch theory is led to get the earth pressure coefficient in the subarea using the trace line of minor principal stress of circular arc after stress deflection. The soil layers at the top and bottom part of the retaining wall are restrained when the drum deformation occurs, and the soil layers are in a non-limit state. The linear relationship between the wall movement’s magnitude and the mobilization of the internal friction angle and the wall friction anger is presented. The level layer analysis method is modified to propose the resultant force of active earth pressure, the action point’s height, and the pressure distribution. Model tests are carried out to emulate the process of drum deformation and soil rupture with limited width. Through image analysis, it is found that the failure angle of soil within the limited width is larger than that of infinite soil. With the increase of the aspect ratio, the failure angle gradually reduces and tends to be constant. Compared with the test results, it is showed that the horizontal earth pressure reduces with the reduction of the aspect ratio within critical width, and the resultant force decreases with the increase of the limit state region under the same ratio. The middle part of the distribution curve is concave. The active earth pressure strength decreases less than Coulomb’s value, the upper and lower soil layers are in the non-limit state, and the active earth pressure strength is more than Coulomb’s value.
Phenylboronic acid modification augments the lysosome escape and antitumor efficacy of a cylindrical polymer brush-based prodrug
Authors: Wang Ruonan , Yin Changfeng , Liu Changren , Sun Ying , Xiao Panpan , Li Jia , Yang Shuo , Wu Wei , Jiang Xiqun 
Published: September 2021

Abstract
Timely lysosome escape is very important for nanomedicines to avoid premature degradation. Herein, we report an exciting finding that phenylboronic acid (PBA) modification can greatly facilitate the lysosome escape of cylindrical polymer brushes (CPBs), and further promote their exocytosis and transcellular transfer. This fundamental finding for the first time reveals that PBA groups improve the tumor penetration of nanomaterials via an active transcytosis mechanism. We speculate that the mechanism of the PBA-enhanced lysosome escape is associated with the specific interactions of the PBA group with the lysosomal membrane proteins and hot shock proteins. The featured advantage of the PBA modification over the known lysosome escape strategies is that it does not cause significant adverse effects on the properties of the CPBs. Furthermore, doxorubicin was conjugated to the PBA-modified CPBs with drug loading content larger than 20%. This CPBs-based prodrug could eradicate the tumors established in mice by multiple intravenous administration.
Transport in Fusion Plasmas: Is the Tail Wagging the Dog?
Authors: Dif-Pradalier Guilhem , Ghendrih Philippe , Sarazin Yanick , Caschera Elisabetta , Clairet Frederic , Camenen Yann , Garbet Xavier , Grandgirard Virginie , Munschy Yann , Vermare Laure , Widmer Fabien 
Published: September 2021

Abstract
Turbulent plasmas notably self-organize to higher energy states upon application of additional free energy sources or modification of edge operating conditions. Mechanisms whereby such bifurcations occur have been actively debated for decades, mostly on the basis of reduced models. Here we unravel a surprising causal chain of events in the onset of an improved confinement state, by applying generic entropy-based and information theoretic measures to the primitive kinetic equations. Interfacial contamination of a large, stable region (the ‘dog’) by locally-borne peripheral turbulent fluctuations (the ‘tail’) is found to be central to explaining transport properties, globally. These results, highly relevant to the quest for magnetic fusion advocate the use of such data-driven methods to many problems in fluids and plasmas where interfacial turbulent contamination is active.