bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coadjuvantes no fortalecimento do sistema imunológico para o enfrentamento ao COVID-19
Authors: Cardoso Eduarda Moreira , Silva Gislene Pinto da , Santos Jânio Sousa 
Published: October 2021

O objetivo do presente artigo foi realizar um estudo de nutrientes e fitoterápicos que podem ser utilizados como coadjuvante no auxílio do fortalecimento do sistema imunológico. Portanto trata-se de uma análise bibliográfica descritiva explicativa que incluir revisão bibliográfica e que contém um recorte temporal de 2013 a 2021, as informações obtidas foram retiradas de bases de dados de documentos científicos, selecionando-se documentos descritos nos idiomas inglês e português, que relatasse sobre reações com SARS-CoV-2 a interação de uma alimentação saudável no cotidiano de fato é muito importante além dos outros métodos de cuidado. As plantas medicinais podem confortar e combater várias doenças infecciosas. O organismo quando se tem uma infecção e bastante vulnerável visto que os microrganismos prejudicam ocasionando deficiências nas células, mesmo que o organismo possuir células que os destrói, contudo precisa-se de nutrientes que transforma o sistema imunológico preferencialmente apto, preservando o equilíbrio para o funcionamento da proteção o sistema imunológico atuam na proteção do organismo diariamente aos ataques contra infecções, quando vírus como o SARS-CoV-2, dominam o organismo, as células entram em ação para combater o vírus e possivelmente obter uma cura ou melhoria do indivíduo. Portanto com base nas literaturas revisadas, concluiu-se que os coadjuvantes como alimentação saudável e fitoterápicos tem disposição de contribuir para reposição de nutrientes capaz de reforçar a imunidade do indivíduo.
Qualidade de vida de cuidadores de idosos leigos associada ao perfil sociodemográfico e situação de saúde
Authors: Rosset Bruna , Tanaka Ana Karina Silva da Rocha , Nora Carlise Rigon Dalla , Matzenbacher Lisiane Paula Sordi , Paczek Rosaura Soares , Lana Letice Dalla 
Published: October 2021

Objetivo: analisar a qualidade de vida de cuidadores de idosos leigos associada ao perfil sociodemográfico e às suas condições de saúde. Métodos: trata-se de uma pesquisa de abordagem quantitativa, descritiva, de cunho transversal, realizada de março a maio de 2021, em que foram avaliados 22 trabalhadores leigos. Os dados foram analisados por meio de estatística descritiva simples e ANOVA. Resultados: pode-se verificar que, entre os 22 respondentes, 90,9% são mulheres. A idade variou entre 20 e 78 anos, sendo a maioria solteira (45,5%). Em relação ao grau de instrução, 45,5% possuem Ensino Médio completo e 12,8% possuem pós-graduação. Dos cuidadores, 45,5% possuem doenças preexistentes. Foram identificadas as seguintes doenças: asma, cardiopatia, hipotireoidismo, diabetes, hipertensão arterial, osteoporose e problemas no joelho. Verifica-se que 59,1% relatam nunca ter procurado auxílio psicológico. Observa-se que 59,01% praticam atividades físicas. Apresenta-se diferença significativa entre os domínios físico e de relações sociais do WHOQOL-bref e entre a categoria divorciado e a categoria de cuidadores com cor de pele branca. Conclusão: esta pesquisa visa a contribuir com novos conhecimentos na área de cuidadores de idosos e auxiliar no entendimento das vulnerabilidades na qualidade de vida dessa população.
O parco registro de desenhos industriais oriundos da moda em Pernambuco
Authors: Mayrinck Pedro Henrique Sobral de Souza Azevedo , Simões-Borgiani Danielle Silva 
Published: October 2021

Objetivo: Analisar a disseminação da proteção para desenhos industriais oriundos da prática profissional do designer de moda nas instituições que fomente empresas emergentes da economia criativa e na formação superior em Design e Design de Moda Pernambuco. Material e Métodos: delimitou-se a pesquisa como aplicada, qualitativa, exploratória, bibliográfica e documental. O recorte temporal foi dos últimos 5 anos (2016 – 2020). Foram analisados projetos pedagógicos de 2 cursos superiores de Bacharelado em Design que possuíam disciplinas de moda e 5 Tecnologia em Design de Moda. Mapeou-se pontos profissionais de apoio/desenvolvimento de moda autoral e nestes, houve 5 eventos de disseminação de Propriedade Intelectual. Resultados: Há uma escassez de eventos que abordem proteção aos desenhos industriais para os ativos oriundos da moda autoral, e, ainda, ausência desse conteúdo na formação superior.
Gerenciamento clínico de eventos tromboembólicos provenientes de complicações da COVID-19: revisão integrativa
Authors: Bispo Laura Dayane Gois , Machado Natan Martins , Paula Caio Lopes Pinheiro de , Oliveira Jussiely Cunha , Santos Ingrid Melo , Pinheiro Fernanda Gomes de Magalhães Soares 
Published: October 2021

Objetivo: identificar de que forma ocorre o gerenciamento clínico de pacientes infectados por COVID-19 que apresentam tromboembolismo pulmonar e/ou tromboembolismo venoso. Método: Trata-se de uma revisão integrativa, realizada através da busca de artigos nas bases de dados BVS, LILACS, MEDLINE, CINAHL E SCOPUS, com delimitação temporal de novembro de 2019 a março de 2021. Resultados: Foram incluídos 24 artigos. O diagnóstico ocorre através do D-dímero e fibrinogênio. Para a terapia medicamentosa, administra-se a Heparina de baixo peso molecular (HBPM), sendo 30 mg/12h em 12h para a anticogulação profilática, doses escalonadas de HBPM com enoxaparina, 0,5 mg/kg duas vezes por dia para a anticoagulação terapêutica e rivoraxabana 10mg/dia para a anticoagulação pós alta. Conclusão: O gerenciamento clínico de TEP e TEV ocorre através do aumento do D-dímero ou do fibrinogênio, com o TEP confirmado através da angiografia pulmonar. Para a anticoagulação, utiliza-se a HBPM, maiormente.
Rhino Conjunctivitis and Asthma Among Seafood Processing Workers in Greenland. A Cross-Sectional Study
Authors: Laustsen Birgitte Hamann , Omland Øyvind , Würtz Else Toft , Sigsgaard Torben , Ebbehøj Niels E. , Carstensen Ole , Rasmussen Kurt , Kamath Sandip D. , Lopata Andreas L. , Bønløkke Jakob Hjort 
Published: October 2021

Introduction: The fishing- and the seafood processing industries are the largest industrial sectors in Greenland. Despite this, only a few cases of occupational diseases in this industry have been reported to the Danish Labor Market Insurance. Occupational asthma and allergy are well-known occupational diseases in the seafood processing industry worldwide and underreporting of occupational diseases in Greenland is suspected.Objective: The aim of the current study was to examine the associations between job exposures and occupational asthma and rhino conjunctivitis in workers in the Greenlandic seafood processing industry and to compare the prevalence of sensitization by type and degree of exposure to snow crab, shrimp, fish, and the fish parasite, Anisakis simplex.Methods: Data from 382 Greenlandic seafood processing workers were collected during 2016–2018. Data included questionnaire answers, lung function measurements, skin prick tests, and blood samples with ImmunoCAP. For all analyses, p &lt; 0.05 was considered the level of significance.Results: 5.5% of the workers had occupational asthma and 4.6% had occupational rhino conjunctivitis. A large proportion of the workers were sensitized to allergens specific to the workplace; 18.1% to snow crab, 13.6% to shrimp, 1.4% to fish, and 32.6% to the fish parasite, A. simplex. We found a dose-response relationship between the risk of being sensitized to snow crab and A. simplex and years of exposure to the allergens in the seafood processing industry.Conclusion: This study showed that a considerable proportion of workers in the Greenlandic seafood processing industry had occupational asthma and rhino conjunctivitis. Additionally, the study showed high sensitization levels toward snow crab, shrimp, and the fish parasite, A. simplex. This supports the hypothesis of a considerable degree of underreporting of occupational allergic airway disease in the Greenlandic seafood processing industry. Prospectively, it is important to inform workers, leaders, and health care professionals of the health problems and the law on worker's compensation, and to initiate preventive actions at factory and trawler level.
Specific Heat Capacity of Confined Water in Extremely Narrow Graphene Nanochannels
Authors: Zhou Runfeng , Ma Xinyi , Li Haoxun , Sun Chengzhen , Bai Bofeng 
Published: October 2021

Specific heat capacity of extremely confined water determines its performance in the heat transfer as the sizes of devices decrease to nanoscales. Here, we report the basic data of the specific heat capacity of water confined in narrow graphene nanochannels below 5 nm in height using molecular dynamics simulations. The results show that the specific heat capacity of confined water is size-dependent, and the commensurability effect of the specific heat capacity presents as the confinement decreases to 1.7 nm. The deviation of specific heat capacity of confined water with that of bulk water is attributed to the variation of configuration features, including density distribution and hydrogen bonds, and vibration features, including velocity auto-correlation function and vibrational density of states. This work unveils the confinement effects and their physical mechanisms of the specific heat capacity of nanoconfined water, and the data provided here have wide prospects for energy applications at nanoscales.
Effect of Lockdown on Pollutant Levels in the Delhi Megacity: Role of Local Emission Sources and Chemical Lifetimes
Authors: Mallik Chinmay , Gadhavi Harish , Lal Shyam , Yadav Rahul Kant , Boopathy R. , Das Trupti 
Published: October 2021

The COVID-19 pandemic resulted in changed emission regimes all over the world. India also imposed complete lockdown on all modes of travel and industrial activities for about 2 months from 25-March-2020 and later unlocked these activities in a phased manner. Here, we study signatures of emissions changes on levels of atmospheric trace gases and aerosols contributing to air pollution over multiple sites in India’s capital Delhi covering various lockdown and unlock phases using satellite data and in-situ observations. The resulting changes in the levels of these species were compared with respect to their average of 2015–2019 to attribute for year to year and seasonal changes. A clear impact of lockdown was observed for AOD, PM, NO2, CO, and SO2 as a result of emission changes, while changed precursor levels led to a change in O3 chemical regimes impacting its concentrations. A detailed analysis of FLEXPART trajectories revealed increased PM levels over Delhi in north-westerly air masses sourced to Punjab region all the way up to Pakistan. Changes in aerosols and NO2 were not only restricted to the surface but transcended the total tropospheric column. The maximum decrease in PM, NO2, CO, and SO2 was observed during the month of total lockdown in April. The lockdown impact varied with species e.g., PM10 and PM2.5 as well as locations even within the periphery of Delhi. While surface level aerosols and NO2 showed significant and almost similar changes, AOD showed much lower decrease than tropospheric column NO2.
Case Report: Lenalidomide as a Second-Line Treatment for Bortezomib-Ineffective Nephrotic Syndrome Caused by LCDD: 2 Case Reports and a Literature Review
Authors: Zhang Xin , Yu Xiao-juan , Wang Su-xia , Zhou Fu-de , Zhao Ming-hui 
Published: October 2021

Background: Light-chain deposition disease (LCDD) is a rare systemic disorder characterized by the deposition of monoclonal light chains in organs. The kidney is a prominent target of light-chain deposition, with a median time to end-stage renal disease (ESRD) of 2.7 years and 5-year ESRD-free survival of 37%. The therapeutic management of LCDD remains ill-defined. In addition to bortezomib-based therapy as first-line therapy, the effect of lenalidomide on LCDD is rarely reported.Case Presentation: This study describes two male LCDD patients in their 60s with nephrotic syndrome and moderately impaired renal function. One patient had monoclonal IgGλ with underlying MGRS, and another had monoclonal IgGκ with underlying monoclonal gammopathy that developed into symptomatic MM during follow-up. The hallmarks of this disease were consistent with previous reports. Both patients initially received BCD therapy, but no hematological response was observed. Consequently, the nephrotic syndrome was refractory. Sequential Rd therapy was initiated, and partial hematological response and nephrotic remission were observed in the IgGλ patient but absent in the IgGκ patient.Conclusion: Limited reports have demonstrated the effect of lenalidomide in LCDD. We report the outcome of lenalidomide in two cases of bortezomib-resistant LCDD. This treatment might be a beneficial supplement for those unresponsive or intolerant to bortezomib in LCDD, but the effect should be prospectively investigated.
Diagnostic Values of Dermatoscopy and CD31 Expression in Cutaneous Lymphangioma Circumscriptum
Authors: Lu Lixia , Yan Siyu , Chen Mingliang , Huang Xiaoyan , Su Juan 
Published: October 2021

Background: Cutaneous lymphangioma circumscriptum is characterized by clusters of deep-seated, vesicle-like papules. Cutaneous lymphangioma circumscriptum (CLC) is not a tumor but rather a congenital malformation of superficial lymphatics.Objectives: The study aimed to describe the dermoscopic features of CLC and investigate the reason why marked blood components in CLC. Moreover, this study sought to increase awareness of the clinical characteristics of CLC and provide insights into CLC diagnosis.Methods: A representative sample of patients with CLC with demographic information and pathological and dermoscopical results was analyzed. The immunohistochemistry of lymphangioma specimens with CD31 and D2-40 was performed. The clinical manifestations of CLC, demographic information, and the results of immunohistochemistry were statistically analyzed to validate the correlation.Results: Besides the pattern of frog spawn-like blisters, lymphangioma also presented as either transparent or pigmented with dark-red to whitish/yellowish shades. Moreover, lymphangioma manifested as a pattern of dermatofibroma. Furthermore, CD31 was detected in the flattened endothelium and only present in dilated spaces containing enough blood or lymph components.Limitations: This study is limited by its retrospective nature and statistical power.Conclusion: Dermoscopy is useful for the diagnosis of CLC. CD31 positive staining and cystic-dilated spaces showed flattened inner and outer endothelia are the diagnostic features in hypopyon-like shape and blisters resembling frog spawn patterns in CLC. These features can assist in the diagnosis of CLC.
ΔCT Value of Amplified Refractory Mutation System Predicts Efficacy of EGFR-TKIs in Advanced Non–Small-Cell Lung Cancer: A Multi-Center Retrospective Study
Authors: Chen Min , Huang Wenqi , Yang Dongyong , Huang Jincheng , Li Gong , Wang Xiaoqing , Xiao Nanjie , Zhang Weijian , Guan Jian , Wang Shuang , Liu Laiyu 
Published: October 2021

Purpose: This multi-center retrospective study determines whether the ΔCT value of the Amplified Refractory Mutation System (ARMS) predicts the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant advanced non–small-cell lung cancer (NSCLC).Patients and methods: Patients who harbored an exon 19 deletion (19Del) or L858R mutation detected by the ARMS and previously received treatment of EGFR-TKIs as a monotherapy were enrolled. A total of 108 NSCLC patients in four hospitals were enrolled. We divided the patients into a high ΔCT group (Group H) and a low ΔCT group (Group L) by the Martingale residuals analysis and log-rank test. The primary outcome was progression-free survival (PFS). Univariate analysis and multivariable regression were applied to compare the PFS between the groups.Result: The Martingale residuals analysis and log-rank test were applied to find the cutoff ΔCT value (0.8). In the 108 patients we enrolled, 59 were in group L and 49 were in group H. Patients’ demographics and clinical characteristics, including age, sex, smoking history, pathology, mutation sites, TNM stage, and line of TKIs therapy, were not significantly different between group L and group H. The median PFS was 11.1 months in group L and 6.9 months in group H, and the difference showed statistical significance (p &lt; 0.001). Moreover, the objective response rates (ORRs) in group L was significantly higher than in group H (61.0 vs 34.7%, p = 0.002). The median OS was 25.0 months in group L and 20.0 months in group H (p = 0.046).Conclusion: The ΔCT value of ARMS could be an efficacy predictor for EGFR-TKI treatment in advanced EGFR-mutant NSCLC.
Both Underweight and Obesity Are Associated With an Increased Risk of Coronavirus Disease 2019 (COVID-19) Severity
Authors: Ye Pian , Pang Ran , Li Ling , Li Hua-Rong , Liu Shuang-Lin , Zhao Lei 
Published: October 2021

Introduction: As coronavirus Disease 2019 (COVID-19) has evolved into a global pandemic, increasing numbers of reports have linked obesity to more severe COVID-19 illness and death. However, almost all the studies focused on an increased risk of mortality or intensive care unit (ICU) admission among hospitalized obese patients with COVID-19. Is obesity also associated with the incidence of acute lung injury (ALI) in the patients with COVID-19? How about underweight patients? The answer is lacking. Therefore, our following research will answer the above two questions.Methods: We collected and analyzed epidemiologic, demographic, clinical, and laboratory data from 193 confirmed cases of COVID-19 at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China, between January 1, 2020, and March 13, 2020. They were followed up until April 15, 2020. Underweight was defined by body mass index (BMI) lower than 18.5 kg/m2, normal weight by 18.5−23.9 kg/m2, overweight by 24.0−27.9 kg/m2, and obesity as ≥28 kg/m2.Results: Among these patients, 5.70% were underweight, 58.03% were normal weight, 27.98% were overweight, and 8.29% were obese. Underweight patients were more likely to have a headache (P = 0.029). Obese patients were more likely than other groups to experience a decline in lymphocyte counts (P = 0.038), an increase in C-reactive protein (CRP; P = 0.023), bilateral multiple mottling, and ground glass opacity in the lungs (P = 0.007). Besides, the proportion of patients receiving human immunoglobulin + systematic corticosteroids treatment is the highest among the obese group compared with other BMI groups. After adjusting for potential confounders, underweight patients had a 6.483-fold higher (P = 0.012), and obese patients showed a 5.965-fold higher odds for developing ALI than normal-weight patients (P = 0.022). In addition, underweight patients were 3.255 times more likely than normal-weight patients to develop secondary infections (P = 0.041).Conclusions: Our study showed that both underweight and obese patients with COVID-19 tend to develop ALI compared with normal-weight patients. Underweight patients were more likely to develop a secondary infection than other patients.
Overall Neutrophil-to-Lymphocyte Ratio and SUVmax of Nodal Metastases Predict Outcome in Head and Neck Cancer Before Chemoradiation
Authors: Werner Jonas , Strobel Klaus , Lehnick Dirk , Rajan Gunesh P. 
Published: October 2021

IntroductionThis study investigates the pretherapeutic neutrophil-to-lymphocyte ratio (NLR) with markers of tumor metabolism in 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and their potential prognostic value in head and neck cancer patients prior to primary chemoradiation.Materials and MethodsNLR and metabolic markers of primary tumor and nodal metastases including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were retrospectively assessed in a consecutive cohort of head and neck squamous cell cancer patients undergoing primary chemoradiation. The main outcome measure was survival.ResultsThe study included 90 patients of which 74 had lymph node metastases at diagnosis. Median follow-up time of nodal positive patients (n=74) was 26.5 months (IQR 18–44). The NLR correlated significantly with metabolic markers of the primary tumor (TLG: rs=0.47, P&lt;0.001; MTV: rs=0.40, P&lt;0.001; SUVmax: rs=0.34, P=0.003), but much less with FDG-PET/CT surrogate markers of metabolic activity in nodal metastases (TLG: rs=0.15, P=0.19; MTV: rs=0.25, P=0.034; SUVmax: rs=0.06, P=0.63). For nodal positive cancer patients, multivariate analysis showed that an increased NLR (HR=1.19, 95% CI=1.04-1.37, P=0.012) and SUVmax of lymph node metastasis (HR=1.09; 95% CI=0.99-1.19; P=0.081) are independently predictive of disease-specific survival. High NLR had a negative prognostic value for overall survival (HR=1.16, 95% CI=1.02-1.33, P=0.021).ConclusionNLR correlates positively with metabolic markers of the primary tumor, suggestive of an unspecific inflammatory response in the host as a possible reflection of increased metabolism of the primary tumor. SUVmax of lymph node metastases and the NLR, however, show no correlation and are independently predictive of disease-specific survival. Therefore, their addition could be used to improve survival prediction in nodal positive head and neck cancer patients undergoing primary chemoradiation.
Outcomes of Recurrent Nasopharyngeal Carcinoma Patients Treated With Salvage Surgery: A Meta-Analysis
Authors: Feng Yekai , Dai Zhimei , Yan Ruicheng , Li Feng , Zhong Xiaosheng , Ye Haoxin , Chen Caiqing , Fan Shaochong , Qing Cheng , Pan Yong , Sun Haiying 
Published: October 2021

ObjectiveTo assess the efficacy of treatment outcomes of salvage surgery for recurrent nasopharyngeal carcinoma (rNPC).MethodsWe conducted a detailed search of the literatures in biomedical databases published from January 1990 to December 2020. The main research features and results of interest were retrieved from the articles that met the selection criteria for meta-analysis.ResultsA total of 21 articles with 778 patients were included, 17 of which met the meta-analysis inclusion criteria. The pooled 2-year overall survival (OS), 5-year OS, and 2-year disease-free survival (DFS) were 71%, 50% and 61%, respectively. Subgroup analysis was conducted with postoperative adjuvant therapy. The pooled 2-year OS, 5-year OS and 2-year DFS of the postoperative adjuvant therapy group compared with the surgery alone group were 69% vs 72%, 44% vs 56%, and 77% vs 54%, respectively. Univariate and multivariate analyses were performed on 178 patients with detailed individual postoperative survival data in 10 articles. On multivariate analysis, recurrent T (RT) stage and adjuvant therapy were independent predictors of outcomes.ConclusionsThis meta-analysis indicated that recurrent NPC patients can obtain survival benefits from salvage surgery. Accurately assessing the RT stage of the tumor and choosing the appropriate surgical method are important to the success of the surgery. Although the prognostic factors influencing outcome have been studied, conclusive data on the survival benefits are still lacking. Random controlled trials (RCTs) to compare surgery alone and postoperative adjuvant therapy are needed in patients with positive margin status after salvage surgery.