bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double-Bundle Posterior Cruciate Ligament Reconstruction
Authors: Stannard James P. , Temperato Joseph , Stannard James T. 
Published: February 2021

AbstractThe optimal surgical technique for posterior cruciate ligament (PCL) reconstruction is a topic of debate among knee surgeons. There are many variables to consider including graft selection, graft fixation method, and single- versus double-bundle reconstruction. While there is a need for ongoing research to elucidate which technique yields the best results, this article discusses recent literature on the topic of single- versus double-bundle PCL reconstruction as well as the senior author's preferred reconstruction method.
Lumbar Puncture Opening Pressure in Patients with Spinal Muscular Atrophy
Authors: Becker Lena-Luise , Weiß Claudia , Tietze Anna , Martiny Viktoria , Kaindl Angela M. 
Published: February 2021

AbstractThe announcement of a hydrocephalus as a possible side effect in patients with spinal muscular atrophy (SMA) receiving the drug nusinersen, promoted major concern and warrants further evaluation. In this retrospective monocentric study, we analyzed clinical data, lumbar puncture opening pressure (LOP) measurement, and ophthalmologic and neuroimaging results in 34 patients with SMA types 1 to 3 undergoing treatment with nusinersen. None of the patients reported symptoms indicative of increased intracranial pressure. In our cohort, the LOP was >20 cm H2O in 25 patients (70.5%), and within this group ≥28 cm H2O in 12 patients (35.3%), in two patients, it was increased prior to treatment initiation. Signs of increased intracranial pressure in ophthalmological assessments or brain imaging were only seen in one patient. We did not identify a correlation between increased LOP and SMA type, scoliosis, or age of the patients; however, it was slightly higher in patients receiving sedation. Our results raise the question whether the LOP is generally increased in SMA as part of the underlying disease, if so, what the etiology is, and whether the increased LOP needs to be treated.
Transtibial Posterior Cruciate Ligament Reconstruction
Authors: Fanelli Gregory C. 
Published: February 2021

AbstractThe keys to successful posterior cruciate ligament (PCL) reconstruction are to identify and treat all pathology, utilize strong graft material, accurately place tunnels in anatomic insertion sites, minimize graft bending, mechanical graft tensioning, secure graft fixation, and the appropriate postoperative rehabilitation program. Adherence to these technical principles results in successful single- and double-bundle arthroscopic transtibial tunnel PCL reconstruction based upon stress radiography, arthrometer, knee ligament rating scales, and patient satisfaction measurements. The purpose of this manuscript is to describe the arthroscopic transtibial tunnel posterior cruciate ligament reconstruction surgical technique.
TSC1 as a Novel Gene for Sleep-Related Hypermotor Epilepsy: A Child with a Mild Phenotype of Tuberous Sclerosis
Authors: Mastrangelo Mario , Commone Chiara , Greco Carlo , Leuzzi Vincenzo 
Published: February 2021

AbstractSleep-related hypermotor epilepsy (SHE) is a rare syndrome that presents with hyperkinetic asymmetric tonic/dystonic seizures with vegetative signs, vocalization, and emotional facial expression, mainly during light non-rapid eye movement sleep stages. The role of various genes (CHRNA4, CHRNB2, CHRNA2, KCNT1, DEPDC5, NPRL2, NPRL3, and PRIMA1) has previously been reported, though genetic etiology is assessed in less than 10% of cases. We report the case of a 5-year-old female carrying the TSC1 variant c.843del p.(Ser282Glnfs*36) who presented with a mild phenotype of tuberous sclerosis, including carbamazepine-responsive SHE, normal neurocognitive functioning, hypomelanotic macules, no abnormalities outside the central nervous system, and tubers at neuroimaging. The presented case extends the list of SHE-related genes to include TSC1, thus suggesting a central pathogenic role of mammalian target of rapamycin (mTOR) cascade dysfunction in SHE and introducing a possible use of mTOR inhibitors in this epileptic syndrome.
Scalp and Forehead Injury: Management of Acute and Secondary Defects
Authors: Namin Arya W. , Tassone Patrick T. , Galloway Tabitha L.I. , Renner Gregory J. , Chang C.W. David 
Published: February 2021

AbstractThe primary challenges in scalp reconstruction are the relative inelasticity of native scalp tissue and the convex shape of the calvarium. All rungs of the reconstructive ladder can be applied to scalp reconstruction, albeit in a nuanced fashion due to the unique anatomy and vascular supply to the scalp. Important defect variables to incorporate into the reconstructive decision include site, potential hairline distortion, size, depth, concomitant infection, prior radiation therapy, planned adjuvant therapy, medical comorbidities, patient desires, and potential calvarium and dura defects.
Clinical Analysis of En Bloc Resection for Advanced Temporal Bone Squamous Cell Carcinoma
Authors: Komune Noritaka , Kuga Daisuke , Matsuo Satoshi , Miyazaki Masaru , Noda Teppei , Sato Kuniaki , Hongo Takahiro , Koike Kensuke , Uchi Ryutaro , Kogo Ryunosuke , Tsuchihashi Nana Akagi , Masuda Shogo , Nakagawa Takashi 
Published: February 2021

Abstract
Objective En bloc and margin-negative surgical resection seems to offer the best prognosis for patients with temporal bone squamous cell carcinoma (TB-SCC). In this study, we summarize the outcomes of surgical cases of advanced TB-SCC (T3–T4) that were managed in two institutions, with an accompanying description of the surgical procedure that was utilized: modified subtotal temporal bone resection (STBR), which involves the en bloc removal of the temporal bone including or transecting the otic capsule.
Design This is a case series study with chart review.
Setting The study was conducted at two academic tertiary care medical centers.
Participants Chart information was collected for all patients who underwent surgical resection of advanced TB-SCC between July 1998 and February 2019. The resulting dataset contained 43 patients with advanced TB-SCC who underwent en bloc resection during the review period. Tumor staging followed the modified Pittsburgh classification. Disease-specific survival (DSS) rates were calculated according to the Kaplan–Meier method.
Main Outcome Measure This study shows disease-specific 5-year DSS rate.
Results The 5-year DSS rate of the cases who underwent en bloc resection was 79.7%. En bloc lateral temporal bone resection was employed in a total of 25 cases (DSS: 79.0%). En bloc modified STBR was utilized in 18 cases (DSS: 81.7%).
Conclusion En bloc margin-negative resection is a reliable treatment strategy for advanced TB-SCC. Modified STBR can be a treatment option for TB-SCC without marked posterior extension.
Repair of Bronchial Anastomosis Following Lung Transplantation
Authors: Chamogeorgakis Themistokles , Moquin Kenneth , Simoff Michael , Nemeh Hassan 
Published: February 2021

Abstract
Background Bronchial anastomotic complications are reported in 2 to 18% of patients after lung transplantation. The majority of complications can be managed with bronchoscopic intervention. When extensive dehiscence is present, surgical intervention can be entertained.
Materials and Methods Between March 1, 2006, and December 31, 2019, our program performed 244 lung transplantations. We conducted a retrospective review of our patient cohort and identified patients who suffered from significant anastomotic complications that required surgical interventions.
Results Twenty-eight and 216 patients underwent single and bilateral lung transplantations, respectively. Eighteen patients developed airway complications (7.4%). The incidence of anastomotic complications was 5.2% (24 complications for a total of 460 bronchial anastomoses). Four patients were managed conservatively. The majority of the bronchial anastomotic complications were managed endoscopically (eight patients). Four patients with associated massive air leak underwent repair of the bronchial anastomosis and two patients were retransplanted because they developed severe distal airway stenosis.
Conclusion Bronchial anastomotic complications are a major cause of morbidity in lung transplantation. The majority of cases can be managed bronchoscopically. In more severe cases associated with massive air leak or imminent massive hemoptysis from bronchopulmonary arterial fistula, surgical intervention is necessary. Aortic homograft interposition along with vascularized pedicle wrapping may be a viable option to re-establish airway continuity when tension-free bronchial anastomotic revision is not possible. In cases with smaller bronchial defects, primary repair with utilization of a vascularized flap can be effective as treatment option.
Clinical Phenotype in an Early-Onset French Pediatric Population: Charcot–Marie–Tooth's Disease Type 2A
Authors: Majorel-Beraud C. , Baudou E. , Walther-Louvier U. , Espil-Taris C. , Beze-Beyrie P. , Cintas P. , Rivier F. , Cances C. 
Published: February 2021

AbstractCharcot–Marie–Tooth's disease type 2A (MCT2A), induced by mutation of the mitofusin 2 (MFN2) gene represents the main cause of MCT2. The aim of this study is to provide details of the clinical and electromyographic phenotype of MCT2A in a pediatric population. We conducted a French multicenter retrospective study, including all children with a genetic diagnosis of MCT2A. Thirteen MCT2A children were included with a beginning of symptoms before the age of 10 years (“early-onset group”). We report two new mutations: c.1070 A → T (p.Lys357.Met) and c.280 C → G (p.Arg94Gly). The evolution of the disease is marked by a fast worsening for three patients with loss of motor autonomy, while the evolution is relatively stable for eight patients. The group of early-onset MCT2A seems more heterogeneous than previously described, with a nonconstant severe phenotype.
Magnetic Resonance Imaging and Cone Beam CT Image Registration for Osseous and Soft Tissue Abnormalities of Temporomandibular Joint: A Systematic Review
Authors: Nagi Ravleen , Nagaraju Rakesh , Naidu Giridhar S. , Reddy Prashanthi , Bibra Ajay , Makkad Ramanpal Singh 
Published: February 2021

Abstract
Introduction Proper diagnosis of temporomandibular disorders (TMDs) is paramount for proper management. Cone beam computed tomography (CBCT) provides additional information about osseous components of TMJ, but diagnosis of soft tissue abnormalities is still a challenging issue for the clinicians. To overcome this, magnetic resonance imaging (MRI) and CBCT registration has shown to be a new promising technique that combines key features of both images into one single fusion image. The purpose of this systematic review was to compile available literature regarding the usefulness of CBCT and MRI-CBCT fusion imaging in proper diagnosis of temporomandibular joint (TMJ) abnormalities.
Materials and Methods Computerized literature search from January 2010 to 2020 using five databases: PubMed (MEDLINE) database (National Library of Medicine, NCBI), Cochrane Database, Scopus, Embase, and Science Direct was conducted by use of medical specific headings (MeSH) keywords.
Results Only 10 articles met the inclusion criteria. Eight articles showed that CBCT accurately detected osseous components of TMJ but has low reliability in diagnosing soft tissue articular disc disorders. Relationship between hard and soft tissues were clearly visualized in fused images.
Conclusion MRI-CBCT image registration is a reliable diagnostic tool for simultaneous evaluation of osseous and soft tissue abnormalities of TMJ and in future more studies should be encouraged to validate its accuracy for TMJ analysis.
Etiological and Clinical Profile of Acute Nonbacterial Encephalitis in Children: A Single-Center Prospective Study
Authors: Cengiz Ali Bülent , Günbey Ceren , Ceyhan Mehmet , Korukluoğlu Gülay , Tanır Başaranoğlu Sevgen , Eroğlu Ertuğrul Nesibe Gevher , Coşgun Yasemin , Konuşkan Bahadır , Özsürekci Yasemin , Anlar Banu 
Published: February 2021

AbstractEncephalitis is a serious neurological syndrome caused by inflammation of the brain. The diagnosis can be challenging and etiology remains unidentified in about half of the pediatric cases. We aimed to investigate demographic, clinical, laboratory, electroencephalographic and neuroimaging findings, and outcome of acute encephalitis of nonbacterial etiology. This prospective study included children hospitalized with the diagnosis of acute encephalitis between 2017 and 2019. Microbiological investigations of the cerebrospinal fluid (CSF) were recorded. All CSF specimens were tested for anti-N methyl D-aspartate receptor (NMDAR) antibodies. In total, 31 children aged 10 months to 17 years (median = 6 years) were included. Pathogens were confirmed in CSF in three patients (9.7%): varicella zoster virus, herpes simplex virus type 1 (HSV-1), and both HSV-1 and NMDAR antibodies. Presenting features included encephalopathy (100%), fever (80.6%), seizure (45.2%), focal neurological signs (29%), and ataxia (19.4%). On clinical follow-up of median 9 (6–24) months, six patients showed neurological deficits: together with two patients who died in hospital, total eight (25.8%) patients were considered to have unfavorable outcome. Need for intubation, receiving immunomodulatory treatment, prolonged hospitalization, and high erythrocyte sedimentation rate at admission were associated with unfavorable outcome. The etiology of encephalitis remains unexplained in the majority of children. HSV-1 is the most frequently detected virus, consistent with the literature. The fact that anti-NMDAR encephalitis was detected in one child suggests autoimmune encephalitis not being rare in our center. The outcome is favorable in the majority while about one-fifth of cases suffer from sequelae.
a-axis YBa2Cu3O7−x/PrBa2Cu3O7−x/YBa2Cu3O7−x trilayers with subnanometer rms roughness
Authors: Suyolcu Y. Eren , Sun Jiaxin , Goodge Berit H. , Park Jisung , Schubert Jürgen , Kourkoutis Lena F. , Schlom Darrell G. 
Published: February 2021

We demonstrate a-axis YBa2Cu3O7−x/PrBa2Cu3O7−x/YBa2Cu3O7−x trilayers grown on (100) LaAlO3 substrates with improved interface smoothness. The trilayers are synthesized by ozone-assisted molecular-beam epitaxy. The thickness of the PrBa2Cu3O7−x layer is held constant at 8 nm, and the thickness of the YBa2Cu3O7−x layers is varied from 24 nm to 100 nm. X-ray diffraction measurements show all trilayers to have &gt;97% a-axis content. The rms roughness of the thinnest trilayer is &lt;0.7 nm, and this roughness increases with the thickness of the YBa2Cu3O7−x layers. The thickness of the YBa2Cu3O7−x layers also affects the transport properties: while all samples exhibit an onset of the superconducting transition at and above 85 K, the thinner samples show wider transition widths, ΔTc. High-resolution scanning transmission electron microscopy reveals coherent and chemically sharp interfaces and that growth begins with a cubic (Y,Ba)CuO3−x perovskite phase that transforms into a-axis oriented YBa2Cu3O7−x as the substrate temperature is ramped up.
Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome
Authors: Al-Mayouf Sulaiman M , Alreefi Hajar A , Alsinan Tuqa A , AlSalmi Ghada , AlRowais Abdulaziz , Al-Herz Waleed , Alazami Anas M , Alsonbul Abdullah , Al-Mousa Hamoud 
Published: February 2021

Abstract

Objectives
To report the phenotypic, genetic findings and outcome of children with lupus manifestations associated with primary immunodeficiency diseases (PIDs).

Methods
Data are retrospectively collected on patients with lupus manifestations and PIDs seen between 1998 and 2019. Data comprised the clinical findings and genetic testing, the response to treatment and the accrual damage related to SLE.

Results
A total of 39 patients (22 female) were reviewed. Thirty-four patients had lupus manifestations and six patients with SLE-like manifestations. Genetic analysis was performed in 25 patients. Complement deficiency was the most frequent PIDs; 26 patients were C1q deficient, three patients had C3 deficiency, two patients had C4 deficiency and one patient with heterozygous C8b variant. The other seven patients had different PIDs genetic defects that include SCID caused by PNP deficiency, CGD, CVID (PIK3CD), IL-2RB mutation, DNase II deficiency, STAT1 mutation, ISG15 mutation and Griscelli syndrome type 3. Mucocutaneous lesions, arthritis and lung involvement were the main clinical features. 84.1% experienced recurrent infections. The mean accrual damage was 2.7 ± 2.2. There were five deaths because of infection.

Conclusion
This study suggests that patients with lupus manifestations and early onset disease, family history of SLE or recurrent infections should undergo immunological work-up and genetic testing to rule out PIDs.
Treatment practices and costs among patients with psoriatic arthritis: A Japanese hospital claims database analysis
Authors: Inui Kentaro , Sato Masayo , Esterberg Elizabeth , Parikh Rohan C , Kimura Shuichi , Torisu-Itakura Hitoe 
Published: February 2021

Abstract

Objective
Assess patient characteristics, real-world treatment patterns, and health care resource utilization (HCRU) among patients with psoriatic arthritis (PsA) in Japan.

Methods
Patients diagnosed with PsA from April 2009 through July 2017 were identified from the Medical Data Vision database. Patient characteristics, treatment patterns, and HCRU were evaluated for these patients.

Results
A total of 639 patients met inclusion criteria and were included in the analysis for patients with a PsA diagnosis. Over 12 months following diagnosis, patients received oral NSAIDs (61.7%), conventional synthetic disease-modifying antirheumatic drugs (DMARDs) (55.1%), corticosteroids (35.1%), topical NSAIDs (34.0%), adalimumab (14.7%), infliximab (9.7%), secukinumab (5.0%), ustekinumab (4.5%), ixekizumab (1.6%), and golimumab (1.6%). A total of 227 (35.5%) patients initiated biologic DMARDs (bDMARDs) over the median 25.2 months of study follow-up. Compared with the overall group of patients diagnosed with PsA, patients who initiated bDMARDs had higher median total per-patient health care costs ($27,772 vs. $11,316), lower median per-patient hospitalization costs ($31,164 vs. $39,359), and fewer median hospital days per admission (8.0 vs. 12.0 days).

Conclusion
This study presents knowledge of the current state of patient characteristics, treatment patterns, HCRU, and costs among patients with PsA in Japan. Considering the relatively recent guideline recommendations, the preliminary treatment patterns suggest physicians may be following treatment guidelines.
Deterministic force-free resonant activation
Authors: Capała Karol , Dybiec Bartłomiej 
Published: February 2021

Abstract
The combined action of noise and deterministic force in dynamical systems can induce resonant effects. Here, we demonstrate a minimal, deterministic force-free setup allowing for the occurrence of resonant, noise-induced effects. We show that in the archetypal problem of escape from finite intervals driven by α-stale noise with a periodically modulated stability index, depending on the initial direction of the modulation, resonant-activation-like or noise-enhanced-stability-like phenomena can be observed. Consequently, in comparison to traditional Lévy flights, Lévy flights with a time-dependent jump length exponent are capable of facilitating or slowing down the escape from finite intervals in an analogous way, such as the modulation of the potential in the resonant activation setup.
Cabin Temperature Regulation-based Charging Strategy for Electric Vehicles Under 5G
Authors: Chenxu Zhao , Chenggang Yang , Ziti Cui , Xianjun Zeng , Zifan Fan , You Zhou 
Published: February 2021

Abstract
As massive EVs are introduced rapidly, large-scale disordered charging loads appear in the power grid, which may lead to "peak plus peak" and overload for local substations. With the rapid development of 5G, the data transmission of large-scale EVs is suggested to help optimizing the orderly charging strategy under cabin temperature control and load control in EVs in this paper. The charging time, charging cost and substation capacity are considered as constraints, so as to optimize the charging period of EVs. It seems that the temperature control dispatching can effectively reduce the disordered charging load of EVs, smooth the overall load curve of the power grid and result "peak shifting and valley filling" of the power grid.
Wind and Solar Integrated Power Prediction Method Research Based on DT-CWT and LSTM
Authors: Ren Yuan , Wang Jinhao , Yang Chaoying , Xiao Chang , Li Shengwen 
Published: February 2021

Abstract
It is very important to improve the wind and solar integrated output power load forecasting technology with the rapid construction of wind and solar hybrid power supply system and the increasing network complexity of microgrid energy system. On the basis of traditional load power forecasting, this paper proposes a wind and solar integrated power prediction method based on dual tree complex wavelet and long short time memory network. In this method, the original power data of photovoltaic and wind power are denoised by DT-CWT. After data reconstruction and transformation, the processed data are trained by multi-port long and short time memory network prediction model, so as to achieve wind power optical integrated power prediction purpose. Finally, the field data of wind and solar hybrid power supply system is used to verify the model. The results show that the method can effectively reduce the impact of power noise during prediction, and improve the accuracy of power prediction of wind and solar hybrid power supply system.
System Stability Risk Quantitative Assessment for Island Operation with PV Plants
Authors: Zhao Haibo , Li Qi , Gao Jin , Zhang Yanhui , Zhang Zhi , Song Junxiao 
Published: February 2021

Abstract
There are stability risks after PV plants drop into island operation, especially in case of unintentional islanding caused by grid faults and the islanding-state detection device fails to operate in time. In order to estimate those risks, firstly, the mechanism of three factors (power difference, PV permeability and motor inertia) influencing the stability characteristics of the island system in a short time after PV unintentionally dropped into island operation is analysed theoretically. Then the electromagnetic transient model of the PV station is established. According to above, the modified Dali Grid integrated with a PV station is modelled in PSCAD/EMTDC, verifying the theoretical analysis conclusions by simulation. Finally, quantitative risk index and assessment method about PV station dropping into islanding are proposed according to the simulation results, which provide the theoretical basis for the stability risk estimation.
Design of online uninterruptible power supply with AC output
Authors: Jiang Ganlin 
Published: February 2021

Abstract
This paper shows the design of an on-line uninterruptible power supply with STM32 as the main controller. It contains rechargeable batteries as the energy storage device and uses inverter technology as the core which can make 29V∼42V AC input to 30V AC RMS output. The system uses STM32 as the control core, it is divided into main controller, autotransformer module, rectifier bridge module, PFC module, inverter module, booster module, battery pack, current and voltage detection module. When the utility power is connected, it supplies power to the inverter module and if it is disconnected, the main control terminal allows the battery to supply power to the inverter module in time, thereby realizing online uninterrupted power supply. Experimental results show that this system can supply power to the load without interruption, and has a good load regulation rate and voltage regulation rate.