bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA damage and expression profile of genes associated with nephrotoxicity induced by butralin and ameliorating effect of Arabic gum in female rats
Authors: Refaie Amel A. , Shalby Aziza B , Kassem Salwa M. , Khalil Wagdy K. B. 
Published: March 2021

Abstract
Nephrotoxicity induced by exposure to environmental pollution including herbicides is became global problem. Natural products are the prime alternative of scientific research as they express better medicinal activity and minor side effects compared with variety of synthetic drugs. This study was performed to evaluate the nephroprotective proficiency of Arabic gum against butralin-induced nephrotoxicity. Adult female rats were supplemented with Arabic gum (4.3 g/kg b.wt) and/or butralin (312 mg/L) in drinking water for 30 days. The results found that markers of serum kidney function, oxidative stress biomarkers, DNA damage and expression of kidney specific genes (Acsm2, ACE and ACE2) as well as histopathological examination in treated rats were conducted. Butralin-treated rats showed a rise in serum creatinine, BUN and MDA as well as decrease in activity of the antioxidant markers. In addition, butralin treatment increased the DNA damage, altered the expression levels of Acsm2, ACE and ACE2 and elevated histopathological lesions in kidney tissues. Pretreatment of Arabic gum prevented butralin-prompted degenerative changes of kidney tissues. The results suggested that the protective effect provided by Arabic gum on renal tissues exposed to the herbicide butralin could be attributed to enhancement of antioxidants and increase the free radicals scavenging activity in vivo.
Statistical downscaling using principal component regression for climate change impact assessment at the Cauvery river basin
Authors: Loganathan Parthiban , Mahindrakar Amit Baburao 
Published: March 2021

Abstract
Climate change impact studies are generally carried out with higher resolution general circulation model (GCM) outputs, which are usually for a global scale, and it is difficult to use the same for a regional scale. GCM simulations require downscaling to get a coarser scale output for local climate impact studies. In this study, an improvised principal component regression (PCR) downscaling technique is adapted to downscale 26 Coupled Model Intercomparison Project Phase 5 (CMIP5) GCM historical outputs. A massive river basin named Cauvery with 35 observation stations is categorized into three subbasins to study the regional climate impacts. In this case, the PCR model performed remarkably well compared to other conventional machine learning models with half the computational time than usual. The test statistics state that the validation of the proposed model illustrates a variance in calibration results of the PCR model, which ranges between 2 and 5%, and a variance in validation, which is less than 7% throughout the study area. Since it is desired to prioritize GCMs to choose the merely suitable models for a strategic climate study, the models were selected based on the PCR model performance. Furthermore, CCSM4, inmcm4, and EC-EARTH model's performance in recreating precipitation statistics over the study area are exceptional.
Optimization of coagulation–flocculation process in the treatment of surface water for a maximum dissolved organic matter removal using RSM approach
Authors: Khettaf Sami , Khouni Imen , Louhichi Ghofrane , Ghrabi Ahmed , Bousselmi Latifa , Bouhidel Kamel-Eddine , Bouhelassa Mohammed 
Published: March 2021

Abstract
The aim of this research work is the optimization of the coagulation/flocculation process in the treatment of surface water for maximum dissolved organic matter (DOM) removal using response surface methodology (RSM). For this purpose, several jar test experiments were performed in order to identify the most influencing factors. Afterwards, RSM was done to investigate the effects and the interactions of three chosen variables (coagulant concentration, flocculant concentration, and initial pH), whereas the responses were the DOM removal in terms of chemical oxygen demand (COD), in terms of absorbance at the wavelength 254 nm (UV-254), and the final pH. The optimal conditions were as follows: 133 mg/L of coagulant, 60 mg/L of flocculant and an initial pH equal to 6.91. Under these conditions, the efficiency removals were 56% in terms of COD and 59% in terms of UV-254 with a final pH equal to 6.78. High variance coefficient R2 values, with 0.96 for the removal in terms of COD and 0.92 in terms of UV-254, confirm the reliability and the validity of the obtained model.
The development in biological wastewater treatment over the last 50 years
Authors: Wanner Jiří 
Published: March 2021

AbstractThe paper summarizes the development in the understanding and practical application of the activated sludge process over the last 50 years. Since its invention, the activated sludge process has been a big challenge to design engineers. Traditionally, the technology was covered by sanitary engineers. However, with the development in the understanding of activated sludge process principles, further progress was not possible without knowledge of reaction kinetics and reactor theory. The shift from BOD removal only to combined removal of organic pollution, nitrogen and phosphorus required a chemical engineering approach with outputs of activated sludge microbiology and microbial ecology. Molecular biology enabled more accurate identification of important activated sludge microorganisms. The development in activated sludge process also required more efficient activated sludge separation and thickening. The paper describes the development from secondary clarifiers to membrane separation. Increasing water stress around the globe has also changed the main wastewater paradigm from wastewater treatment and safe discharge to safe reuse.
PERFIL DE PRODUÇÃO CIENTÍFICA DOS DOCENTES EM UMA INSTITUIÇÃO FEDERAL DE ENSINO SUPERIOR NO BRASIL
Authors: Mafra Cláudio 
Published: March 2021

Prática incomum nas universidades, conhecer sua produção científica pode ser útil para o estabelecimento de estratégias de desenvolvimento institucional e nacional. Assim, buscou-se traçar o perfil da pesquisa e produção científica do corpo docente de uma instituição frequentemente citada nacional e internacionalmente por sua qualidade acadêmica, reconhecida, em 2017, como a 12ª mais produtiva em todo o País, mas que no entanto apresentou baixos índices quanto a parâmetros qualitativos desta produção. Verificou-se acentuada concentração desta produção científica em periódicos bem classificados na base Qualis, entretanto como de baixo fator de impacto, sendo esta devida a um número muito reduzido de docentes, em um universo no qual quantidade significativa nunca foi citada por seus pares ou sequer logrou a divulgação de algum produto científico em veículo indexado em bases internacionais. São apresentadas diferentes variáveis desta produção científica e sistemas internos para avaliação e progressão funcional nesta instituição. Apresenta-se como a utilização inadequada de uma ferramenta para avaliação de programas de pós-graduação negativamente interferiu na qualidade de toda a produção científica e gestão da instituição, bem como sobre a formação dos futuros mestres e doutores. Concluindo pela adequação de avaliações desta natureza em outras instituições federais de ensino superior no Brasil, são apresentadas para reflexão medidas que poderiam ser implementadas com o intuito de incrementar a qualidade científica desta produção científica, bem como racionalizar a utilização dos recursos públicos a estas instituições destinados, baseado em um processo intrínseco e contínuo de gestão do conhecimento científico.
VINTE ANOS DO PORTAL DE PERIÓDICOS DA CAPES
Authors: Damasceno Ramalho Welandro , De Almeida Silva Patrícia , Batista Teixeira da Rocha João 
Published: March 2021

O objetivo dessa pesquisa é apresentar uma análise técnica que permita a elaboração de uma visão panorâmica dos resultados dos trabalhos realizadas pela CAPES na gestão do Portal de Periódicos ao longo de seus vinte anos de existência, em especial quanto à evolução dessa biblioteca digital em relação aos conteúdos, às instituições, às áreas de conhecimento contempladas, bem como aos aspectos financeiros que suportaram as atividades do Portal entre 2000 e 2020. Para o período analisado, o Portal atendeu entre 72 e 436 instituições acadêmicas e científicas diferentes. Entre 2001 e 2019 houve um total de 1.566.562.037 de acessos aos conteúdos disponíveis em todas as grandes áreas, em especial à de Ciências da Saúde, que, em média, compõe aproximadamente 20% dos conteúdos disponibilizados. Apesar das oscilações do dólar americano, que é a moeda de pagamento de 388 contratos realizados, o custo médio ao acesso a textos completos e às bases de dados tenderam a uma significativa redução quando comparados os valores de 2001 e 2018. O elevado número de acessos aliado à expansão da quantidade de material disponível, instituições participantes, orçamento e usuários reafirmam a importância que essa biblioteca digital possui para o cenário da pesquisa científica nacional. Por fim, os dados apresentados vão ao encontro da conclusão de Almeida, Guimarães e Alves (2010) que o Portal de Periódicos da CAPES assume um papel preponderante como Política de Estado que promove o acesso à informação científica no Brasil.
Tablet-Based Telerehabilitation Versus Conventional Face-to-Face Rehabilitation After Cochlear Implantation: Prospective Intervention Pilot Study
Authors: Völter Christiane , Stöckmann Carolin , Schirmer Christiane , Dazert Stefan 
Published: March 2021

Background
Technologies allowing home-based rehabilitation may be a key means of saving financial resources while also facilitating people’s access to treatment. After cochlear implantation, auditory training is necessary for the brain to adapt to new auditory signals transmitted by the cochlear implant (CI). To date, auditory training is conducted in a face-to-face setting at a specialized center. However, because of the COVID-19 pandemic’s impact on health care, the need for new therapeutic settings has intensified.

Objective
The aims of this study are to assess the feasibility of a novel teletherapeutic auditory rehabilitation platform in adult CI recipients and compare the clinical outcomes and economic benefits of this platform with those derived from conventional face-to-face rehabilitation settings in a clinic.

Methods
In total, 20 experienced adult CI users with a mean age of 59.4 (SD 16.3) years participated in the study. They completed 3 weeks of standard (face-to-face) therapy, followed by 3 weeks of computer-based auditory training (CBAT) at home. Participants were assessed at three intervals: before face-to-face therapy, after face-to-face therapy, and after CBAT. The primary outcomes were speech understanding in quiet and noisy conditions. The secondary outcomes were the usability of the CBAT system, the participants’ subjective rating of their own listening abilities, and the time required for completing face-to-face and CBAT sessions for CI users and therapists.

Results
Greater benefits were observed after CBAT than after standard therapy in nearly all speech outcome measures. Significant improvements were found in sentence comprehension in noise (P=.004), speech tracking (P=.004) and phoneme differentiation (vowels: P=.001; consonants: P=.02) after CBAT. Only speech tracking improved significantly after conventional therapy (P=.007). The program’s usability was judged to be high: only 2 of 20 participants could not imagine using the program without support. The different features of the training platform were rated as high. Cost analysis showed a cost difference in favor of CBAT: therapists spent 120 minutes per week face-to-face and 30 minutes per week on computer-based sessions. For CI users, attending standard therapy required an average of approximately 78 (SD 58.6) minutes of travel time per appointment.

Conclusions
The proposed teletherapeutic approach for hearing rehabilitation enables good clinical outcomes while saving time for CI users and clinicians. The promising speech understanding results might be due to the high satisfaction of users with the CBAT program. Teletherapy might offer a cost-effective solution to address the lack of human resources in health care as well as the global challenge of current or future pandemics.
Administración de la infraestructura estratégica en el Sector Defensa de Colombia. Relación con la estrategia adoptada por España
Authors: Avila Bernal Sandra Marcela 
Published: March 2021

Introducción: Este artículo realiza un análisis a lo conexo con la protección de la Infraestructura Estratégica - Crítica desde el Sector Defensa. Entiende el fenómeno que concibe su protección, e identifica las lecciones aprendidas que permiten, incluso, ubicar el punto de partida en el que el sector a través de la Fuerza Pública puede encontrarse, de acuerdo con parámetros comparativos del caso España. Metodología: se realizó una entrevista a personal experto en temas de seguridad y defensa, así como en temas de seguridad pública y de infraestructura, con preguntas abiertas y cerradas a quienes se encontraban en un Nivel Directivo, Medio y Operacional, con el fin de poder recoger tanto su conocimiento, experticia y su visión de la temática propuesta, y así, obtener resultados objetivos, críticos y confiables. También, se estructuró una lista de chequeo con el fin de lograr realizar una comparación de las principales características que permitan verificar el grado de desarrollo del Programa de Protección de Infraestructura Crítica con que cuenta actualmente España, frente a lo encontrado en el Sector Defensa y con el fin de acotar la fase de confirmación y validación de la investigación que se realizó a través del Grupo de Expertos consultados, mediante una retroalimentación de los resultados obtenidos. Resultados: La presente investigación, además de tener un matiz diferenciador de las temáticas normalmente abordadas, permite resaltar que las ciencias sociales son fundamentales para la investigación de Infraestructura Estratégica - Crítica, de manera transdisciplinaria de varias formas. En este sentido, se intentó considerar a lo largo de esta investigación “la importancia de la seguridad y defensa como agentes del desarrollo económico estable y sostenible” (Medeiros & Pereyra Bordón, s. f., p.115). Permitiendo suministrar, descripciones que serán esenciales para generar juicios de transferibilidad[3] al contexto del Sector Defensa sobre la protección y administración de la Infraestructura Estratégica - Crítica, situación concreta con características singulares.
Menyelidiki Loyalitas Millenial pada Transportasi Online; Studi Mediasi berbasis SEM-PLS
Authors: Ashoer Muhammad , Syahnur Muhammad Haerdiansyah , Taufan Rezky Ratnasari , Siangka Andi Nursiskawanti 
Published: March 2021

The massive transformation of consumer behaviour on the online transportation network platform in Indonesia has still not yet answered comprehensively. We have identified and evaluated several latent constructs based on prior research review. Hence, we investigate the effect of electronic customer relationship management (e-CRM) on e-satisfaction and e-loyalty of online transportation costumer. We applied a causality approach method to measure the primary data, and then we selected respondents with purposive sampling technique which have met the predetermined criterion. In total, there was 142 customer have participated in this online survey. To examine the primary data, we used the variance-based analysis of Structural Equation Model (SEM) - Partial Least Square (PLS) analytical instruments. The results have a significant managerial and theoretical contribution to the stakeholder to make a customer keep loyal in ever-changing e-commerce business in Indonesia.
STRUKTUR HISTOLOGI KARTILAGO EPIFISIALIS FETUS MENCIT (Mus musculus L.) SETELAH PEMBERIAN EKSTRAK METANOL RIMPANG TEKI (Cyperus rotundus L.)
Authors: Arismedi Puty Orlando , Nurcahyani Nuning , Busman Hendri 
Published: March 2021

Rimpang teki (Cyperus rotundus L.) mengandung senyawa saponin, sineol, pinen, siperon, rotunol, siperenon, tanin, siperol, alkaloid, flavonoid, tanin, pati, glikosida dan furochromones, serta seskuiterpenoid. Dengan hadirnya senyawa ini diperlukan untuk menguji efek samping penggunaannya pada janin. Tujuan penelitian ini adalah untuk mengetahui efek pemberian ekstrak rimpang rumput teki terhadap kelainan struktur histologi tunas anggota depan fetus mencit (Mus musculus L) yang diberikan pada masa prenatal. Dosis ekstrak rimpang rumput teki yaitu: 45 mg/40g BB dalam 0,4 ml aquabides (P2), 90 mg/40g BB dalam 0,4 ml aquabides (P3), 135 mg/40g BB dalam 0,4 ml aquabides (P4), dan 0,4 ml aquabides (K) sebagai kontrol. Parameter yang diamati mencakup zona cadangan kondrosit, zona proliferasi, zona maturasi, dan zona kartilago yang mengalami mineralisasi. Data dianalisis dengan analisis ragam dan diuji lanjut dengan uji beda nyata terkecil (BNT) pada taraf 5%. Hasil penelitian menunjukkan bahwa peningkatan perlakuan dosis ekstrak rimpang rumput teki memberikan pengaruh nyata terhadap penurunan ketebalan zona cadangan kondrosit, zona proliferasi, dan zona maturasi. Perlakuan dosis 135 mg/40g BB dalam 0,4 ml aquabides (P4) memberikan pengaruh terhadap penurunan ketebalan zona kartilago yang mengalami mineralisasi yaitu dari rerata 563,33µm menjadi 481,66µm.
PENGARUH PEMBERIAN STRESS OSMOTIK TERHADAP KADAR TOTAL LIPID MIKROALGA Porphyridium sp. DAN Isochrysis sp. PADA SALINITAS YANG BERBEDA
Authors: Anggraini Lia , Widiastuti Endang Linirin , Murwani Sri 
Published: March 2021

Mikroalga merupakan salah satu produsen primer yang diduga memiliki kandungan lipid tinggi untuk dimanfaatkan sebagai energi alternatif. Mikroalga yang memiliki kandungan lipid cukup tinggi diantaranya adalah Porphyridium sp. dan Isochrysis sp. Pemberian stress osmotik diduga dapat meningkatkan kadar total lipid mikroalga Porphyridium sp. dan Isochrysis sp. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian stress osmotik berupa perbedaan salinitas terhadap kadar total lipid pada mikroalga Porphyridium sp. dan Isochrysis sp. Penelitian ini telah dilaksanakan pada bulan Januari - Februari 2016 di Laboratorium Biologi Molekuler Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Lampung. Penelitian ini menggunakan Rancangan Acak Lengkap dengan faktorial yang terdiri dari 2 jenis mikroalga serta 4 taraf salinitas 20 ppt, 25 ppt, 30 ppt, dan 35 ppt, serta 3 kali ulangan. Parameter yang diamati yaitu kepadatan populasi, laju pertumbuhan, dan kadar total lipid. Data dianalisis dengan Analysis of Variance (ANOVA) dan diuji lanjut dengan Uji Tukey HSD pada taraf 5 %. Hasil penelitian menunjukkan bahwa kepadatan populasi tertinggi terjadi pada perlakuan Isochrysis sp. pada salinitas 35 ppt. Mikroalga yang menyumbang lipid tertinggi pada tiap selnya adalah Porphyridium sp. pada salinitas 20 ppt sebesar 6x10-6 g/sel dan Isochrysis sp. pada salinitas 20 ppt sebesar 45x10-7 g/sel.
PERBANDINGAN PERKEMBANGAN LARVA Graphium agamemnon (LEPIDOPTERA: PAPILIONIDAE) PADA BEBERAPA JENIS TANAMAN PAKAN LARVA
Authors: Fallupi Nikken , Rosa Emantis 
Published: March 2021

Penelitian perbandingan perkembangan larva Graphium agamemnon pada beberapa jenis tanaman pakan larva dilakukan pada bulan Februari-April 2016 di Taman Kupu-kupu Gita Persada Lampung untuk mengetahui perbandingan perkembangan larva pada enam jenis tanaman dan mengetahui tanaman yang paling baik digunakan dalam perkembangan larva. Penelitian menggunakan metode rancangan acak kelompok dengan 10 kali pengulangan. Lima pasang kupu-kupu G. agamemnon dilepaskan dalam kandang penangkaran untuk mendapatkan telur. Setelah menetas, larva G. agamemnon dikembangkan pada daun enam jenis tanaman pakan larva yaitu sirih hutan (Piper aduncum), cempaka (Michelia champaca), sirsak (Annona muricata), alpukat (Persea americana), glodokan (Polyalthia longifolia), dan srikaya (Annona squamosa). Parameter yang diukur adalah panjang tubuh, berat tubuh, lebar kepala, dan lama waktu untuk menjadi pupa. Data yang diperoleh kemudian di analisis dengan menggunakan ANARA yang dilanjutkan dengan uji BNT pada taraf nyata 5 %, dengan bantuan program SPSS versi 16. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan perkembangan larva G. agamemnon pada enam jenis tanaman pakan larva. Pada instar dua dan instar tiga, pertumbuhan panjang dan berat larva pada tanaman sirih hutan lebih baik dari pada larva pada tanaman pakan yang lainnya. Lama waktu perkembangan yang dibutuhkan larva menjadi pupa paling cepat adalah 17 hari yaitu pada tanaman sirih hutan.
PERBANDINGAN PUPASI DUA JENIS KUPU-KUPU Troides helena DAN Pachliopta aristolochiae (LEPIDOPTERA: PAPILIONIDAE)
Authors: Apriyanti Emilia , Soekardi Herawati , Nukmal Nismah 
Published: March 2021

T. helena dan P. aristolochiae merupakan spesies kupu-kupu yang memakan tanaman pakan yang sama (Aristolochia tagala) pada fase larva. Ketika akan memasuki fase pupa, larva kupu-kupu T. helena dan P. aristolochiae mengalami pupasi yang diawali dengan aktifnya hormon prothoracicotropic (PTTH) yang memicu larva untuk berhenti makan. Penelitian ini bertujuan untuk membandingkan tahapan dan waktu yang dibutuhkan dari awal pupasi hingga terbentuk pupa dari dua jenis kupu-kupu. Penelitian dilakukan pada bulan Januari 2016 di Taman Kupu-kupu Gita Persada Lampung. Sepuluh larva instar terakhir T. helena dan P. aristolochiae hasil penangkaran diamati aktivitasnya setiap satu jam hingga terbentuk pupa, serta pengukuran panjang benang dan penimbangan berat pupa. Data yang diperoleh dianalisis secara deskriptif, uji t (Independent Sample Test), dan analisis korelasi untuk panjang benang dan berat pupa. Hasil menunjukkan bahwa pada awal memasuki pupasi, larva instar terakhir T. helena dan P. aristolochiae memiliki aktivitas yang sama, yaitu berhenti makan dan mencari tempat yang cocok yang akan digunakan sebagai tempat menggantung. Larva memendekkan tubuhnya, membuat benang, menggantung dan kemudian membentuk pupa. Pembuatan benang T. helena dan P. aristolochiae terjadi pada malam hari. Hasil analisis uji t menunjukkan bahwa rata-rata lama pupasi kupu-kupu T. helena dan P. aristolochiae berbeda nyata ( < 0,03), rata- rata pupasi T. helena 4,8 jam lebih lama dibandingkan P. aristolochiae. Adanya korelasi positif antara panjang benang dan berat dengan nilai r T. helena : 0,94 dan r P. aristolochiae : 0, 60