bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survey-Based Research of Knowledge and Perception of Endodontic Treatment on an Indian Subpopulation
Authors: Saji Shalin Ann , Shetty Chitharanjan , Shetty Aditya , Hegde Mithra N. 
Published: November 2021

Abstract
Objective To assess the patients' knowledge and perceptions regarding endodontic treatment.
Materials and Methods A questionnaire-based survey was conducted in a group of 400 patients, consisting of questions based on sociodemographic details as well as their knowledge about endodontic treatment. The collected data was tabulated and analyzed using methods of descriptive analysis.
Results The majority of the respondents stated their level of knowledge regarding endodontic treatment as average.
Conclusion Within the limitations of the study, an improvement in the knowledge regarding endodontic treatment among patients was observed.
Clinical Significance Population-based surveys are useful for evaluating the community and patients' mentality toward endodontic treatment. Proper information regarding the treatment modalities can be explained to the patient based on their lack of information, which is of utmost importance to develop a positive approach to root canal treatment.
Peri-Implant Diseases
Authors: Das Dipanjan , Shenoy Nina 
Published: November 2021

AbstractOsseointegrated dental implants have become an increasingly popular modality of treatment for the replacement of absent or lost teeth because of its high rates of long-term survival when used to support various types of dental prostheses. However, complications and implant failure can still occur and are considered by many clinicians as a major obstacle for implant treatment. Biological complications mainly refer to inflammatory conditions of the soft tissues and bone surrounding implants and their restorative components, which are induced by the accumulation of bacterial biofilm. Two clinical varieties may be distinguished: peri-implant mucositis and peri-implantitis. Peri-implant mucositis is a reversible, plaque-induced inflammatory lesion confined to the peri-implant soft tissue unit, whereas peri-implantitis is an extension of peri-implant mucositis to involve the bone supporting the implant. Diagnosing and managing these biological complications is of utmost importance for the implant surgeon and dental practitioner. This review encompasses the etiology, diagnostic aspects, prevention, and management of biological complications.
An Assessment of Dental Anxiety in Patients Before and After Scaling and Polishing Procedures
Authors: Sreeja Sai S. , Bhandary Rahul , Bhat Amitha Ramesh , Shenoy Nina 
Published: November 2021

AbstractIntroduction As of now, there are not many investigations about the improvement of dental apprehension and dental participation in various populations over time. This investigation includes an examination of emotional appraisals of levels of dental apprehension in patients selected at the AB Shetty Memorial Institute of Dental Sciences. The investigation also aimed to discover the causes of dental apprehension as well as the effect of sexuality on the distinguished dental apprehension.Materials and Methods The level of dental apprehension was assessed using questionnaires that included 15 questions before and after the scaling and polishing procedures for 78 patients. The typical features were drawn such as gender, age, and oral hygiene habits. The data analysis was analyzed using paired t-test or Wilcoxon signed rank test to assess pre- and postanxiety levels.Results A total of 78 responses were collected, resulting in a participation rate of 100%. Despite the fact that women had significantly higher overall dental apprehension levels compared with men, the discrepancy among the two genders was substantial and could be clarified.Conclusion Dental fear was common in females, especially among those with dental problems, and a larger degree of dental fear can contribute to periodontal disease.
An Interesting Case of Bilateral Hilar Lymphadenopathy Presented with Visual Impairment
Authors: MT Chandramouli , Baikunje Nandakishore , Y. Sunil Kumar , K. Subrahmanya Bhat , Bajaj Darshan , Hosmane Giridhar Belur 
Published: November 2021

AbstractSarcoidosis is a systemic granulomatous disease of unknown etiology. It primarily affects the lungs and lymphatics; however, the presentation is not always pulmonary. Uveitis is the presenting symptom in 5% of patients, predominantly in females. Cystoid macular edema is the most important sight-threatening sequela of ocular sarcoidosis. Histopathological evidence of noncaseating epithelioid granulomas from a biopsy is the gold standard for the diagnosis of ocular sarcoidosis. Diagnosis of sarcoidosis is made by exclusion of other causes of granulomatous disease, mainly tuberculosis and fungal infection and documentation of involvement of at least one additional organ system. The authors present a case of a patient with sarcoidosis involving lungs and eyes, who had uveitis as an initial presentation.
A Clinical Decision Support System Design Framework for Nursing Practice
Authors: Lu Sheng-Chieh , Brown Rebecca J. , Michalowski Martin 
Published: November 2021

AbstractBackground As nurses increasingly engage in decision-making for patients, a unique opportunity exists to translate research into practice using clinical decision support systems (CDSSs). While research has shown that CDSS has led to improvements in patient outcomes and nursing workflow, the success rate of CDSS implementation in nursing is low. Further, the majority of CDSS for nursing are not designed to support the care of patients with comorbidity.Objectives The aim of the study is to conceptualize an evidence-based CDSS supporting complex patient care for nursing.Methods We conceptualized the CDSS through extracting scientific findings of CDSS design and development. To describe the CDSS, we developed a conceptual framework comprising the key components of the CDSS and the relationships between the components. We instantiated the framework in the context of a hypothetical clinical case.Results We present the conceptualized CDSS with a framework comprising six interrelated components and demonstrate how each component is implemented via a hypothetical clinical case.Conclusion The proposed framework provides a common architecture for CDSS development and bridges CDSS research findings and development. Next research steps include (1) working with clinical nurses to identify their knowledge resources for a particular disease to better articulate the knowledge base needed by a CDSS, (2) develop and deploy a CDSS in practice using the framework, and (3) evaluate the CDSS in the context of nursing care.
Management of Symptomatic Meckel's Diverticulum in Infants and Children
Authors: Ghritlaharey Rajendra K. 
Published: November 2021

Objectives
The primary objective of the present study was to review the demographics of infants and children operated upon for Meckel's diverticulum. The secondary objectives were to review the clinical characteristics, surgical procedures performed, postoperative complications, and the outcome.

Materials and Methods
This study is a single-institutional, retrospective study and descriptive in nature. It consisted of infants and children below 12 years who were operated upon for Meckel's diverticulum at the author's institute and included data from January 1, 2000 to December 31, 2020.

Results
Eighty-four children below 12 years were operated upon for Meckel's diverticulum during the study period. The ratio for males to females was 3:1. This study consisted of infants, (n = 22, 26.19%), children of 1 to 5 years of age (n =19, 22.61%), and children of 6 to 12 years of age (n = 43, 51.19%). Clinically, children with Meckel's diverticulum presented in the following order of frequency: (1) intestinal obstruction (n = 59, 70.23%), (2) perforation peritonitis (n = 17, 20.23%), (3) lower gastrointestinal bleeding (n = 4, 4.76%), and (4) incidental finding (n = 4, 4.76%). In 35 (41.66%) children, bowel gangrene was detected. One-fifth (n = 17) of Meckel's diverticulum was responsible for the secondary intussusception. The surgical procedures were performed in the following order of frequency: (1) resection of Meckel's diverticulum, an adjacent segment of ileum and ileoileal anastomosis (n = 36, 42.85%); (2) Meckel's diverticulectomy (n = 32, 38.09%); (3) resection of Meckel's diverticulum, an adjacent segment of ileum with or without cecum and an ileostomy (n = 12, 14.28%); and (4) resection of Meckel's diverticulum, an adjacent segment of ileum, cecum, part of the colon, and ileocolic anastomosis (n = 4, 4.76%). In 8 (9.52%) children, complications were documented during the postoperative period. The present study observed three (3.57%) deaths during the postoperative period.

Conclusion
Meckel's diverticulum was one of the common causes of acute intestinal obstruction in infants and older children. Ninety percent of children with Meckel's diverticulum presented with features of an acute abdomen. Forty percent of children evidenced bowel gangrene during the surgical procedures. In these children, early diagnosis, timely referral, and institution of surgical therapy for acute abdomen/intestinal obstruction may prevent the development of bowel gangrene and the requirement of bowel resections to some extent.
A novel Nb superconducting joint with ultralow resistance fabricated by electron beam welding method for superconducting gravimeter
Authors: Zhang Zili , Huang Xing , Cui Chunyan , Wang Hao , Niu Feifei , Zhang Yuan , Kong Xiangdong , Han Li , Wang Lei , Hu Xinning , Wang Qiuliang 
Published: November 2021

Abstract
This paper presents a novel Nb superconducting joint with an ultralow resistance of 7.9 × 10−16 Ω, fabricated using the electron beam welding (EBW) method. After the EBW process, the two Nb filaments formed a single joint with a much larger grain size and smaller grain misorientation. More importantly, the resistance of the EBW Nb joint was nearly one magnitude lower than that of most conventional pressing joint. The ultralow resistance is essential for superconducting gravimeters, which require an extremely low drift rate. The EBW Nb joint allowed the superconducting gravimeter to have a much better performance when applied in the field of structural geology, geodesy, microgravity, and metrology. We believe that the EBW method could be one of the most promising joint fabrication methods for achieving maximum stability (less than 1 μgal yr−1).
Disorder in parity–time symmetric quantum walks
Authors: Xue Peng 
Published: November 2021

Abstract
We experimentally investigate the impact of static disorder and dynamic disorder on the non-unitary dynamics of parity–time (PT)-symmetric quantum walks. Via temporally alternating photon losses in an interferometric network, we realize the passive PT-symmetric quantum dynamics for single photons. Controllable coin operations allow us to simulate different environmental influences, which result in three different behaviors of quantum walkers: a standard ballistic spread, a diffusive behavior, and a localization, respectively, in a PT-symmetric quantum walk architecture.
Asteroids, Holoblack and Clearance Futurism
Authors: McConville Pat 
Published: November 2021

Abstract
In this paper, I argue that the video game Asteroids’ enduring appeal turns on its ability to be read as futurist text. I connect Asteroids’ black and white aesthetic to the phenomenologist Vivian Sobchack’s notion of postfuturism. Central to postfuturism is a change from representations of space as deep to representations of space as surface, incapable of concealment. I consider materials designed to absorb almost all visible light—which I call holoblacks—as pushing past representations of space as surface into a paradigm of non-representation of space or space as non-representation. I argue that this non-representation is what is meant by Martin Heidegger in the concept of a thing. I therefore offer an interpretation of Heidegger’s Lichtung, or clearing, in which holoblacks act as a vehicle for the gathering, disclosure and nearing of world which I call ‘clearance futurism’. I conclude by reading Asteroids as a clearance futurist text.
Immuno-informatics analysis predicts B and T cell consensus epitopes for designing peptide vaccine against SARS-CoV-2 with 99.82% global population coverage
Authors: Shukla Priyank , Pandey Preeti , Prasad Bodhayan , Robinson Tony , Purohit Rituraj , D’Cruz Leon G , Tambuwala Murtaza M , Mutreja Ankur , Harkin Jim , Rai Taranjit Singh , Murray Elaine K , Gibson David S , Bjourson Anthony J 
Published: November 2021

Abstract
The current global pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has taken a substantial number of lives across the world. Although few vaccines have been rolled-out, a number of vaccine candidates are still under clinical trials at various pharmaceutical companies and laboratories around the world. Considering the intrinsic nature of viruses in mutating and evolving over time, persistent efforts are needed to develop better vaccine candidates. In this study, various immuno-informatics tools and bioinformatics databases were deployed to derive consensus B-cell and T-cell epitope sequences of SARS-CoV-2 spike glycoprotein. This approach has identified four potential epitopes which have the capability to initiate both antibody and cell-mediated immune responses, are non-allergenic and do not trigger autoimmunity. These peptide sequences were also evaluated to show 99.82% of global population coverage based on the genotypic frequencies of HLA binding alleles for both MHC class-I and class-II and are unique for SARS-CoV-2 isolated from human as a host species. Epitope number 2 alone had a global population coverage of 98.2%. Therefore, we further validated binding and interaction of its constituent T-cell epitopes with their corresponding HLA proteins using molecular docking and molecular dynamics simulation experiments, followed by binding free energy calculations with molecular mechanics Poisson–Boltzmann surface area, essential dynamics analysis and free energy landscape analysis. The immuno-informatics pipeline described and the candidate epitopes discovered herein could have significant impact upon efforts to develop globally effective SARS-CoV-2 vaccines.
Outcome reporting in therapeutic mammaplasty: a systematic review
Authors: Lee Alice , Kwasnicki Richard M , Khan Hasaan , Grant Yasmin , Chan Abigail , Fanshawe Angela E E , Leff Daniel R 
Published: November 2021

Abstract

Background
Therapeutic mammaplasty (TM) is an oncological procedure which combines tumour resection with breast reduction and mastopexy techniques. Previous systematic reviews have demonstrated the oncological safety of TM but reporting of critically important outcomes, such as quality of life, aesthetic and functional outcomes, are limited, piecemeal or inconsistent. This systematic review aimed to identify all outcomes reported in clinical studies of TM to facilitate development of a core outcome set.

Methods
Medline, EMBASE, CINAHL and Web of Science were searched from inception to 5 August 2020. Included studies reported clinical outcomes following TM for adult women. Two authors screened articles independently for eligibility. Data were extracted regarding the outcome definition and classification type (for example, oncological, quality of life, etc.), time of outcome reporting and measurement tools.

Results
Of 5709 de-duplicated records, 148 were included in the narrative synthesis. The majority of studies (n = 102, 68.9 per cent) reported measures of survival and/or recurrence; approximately three-quarters (n = 75, 73.5 per cent) had less than 5 years follow-up. Aesthetic outcome was reported in half of studies (n = 75, 50.7 per cent) using mainly subjective, non-validated measurement tools. The time point at which aesthetic assessment was conducted was highly variable, and only defined in 48 (64.0 per cent) studies and none included a preoperative baseline for comparison. Few studies reported quality of life (n = 30, 20.3 per cent), functional outcomes (n = 5, 3.4 per cent) or resource use (n = 28, 18.9 per cent).

Conclusion
Given the oncological equivalence of TM and mastectomy, treatment decisions are often driven by aesthetic and functional outcomes, which are infrequently and inconsistently reported with non-validated measurement tools.
Semantic scene-object consistency modulates N300/400 EEG components, but does not automatically facilitate object representations
Authors: Chen Lixiang , Cichy Radoslaw Martin , Kaiser Daniel 
Published: November 2021

Abstract
During natural vision, objects rarely appear in isolation, but often within a semantically related scene context. Previous studies reported that semantic consistency between objects and scenes facilitates object perception and that scene-object consistency is reflected in changes in the N300 and N400 components in EEG recordings. Here, we investigate whether these N300/400 differences are indicative of changes in the cortical representation of objects. In two experiments, we recorded EEG signals, while participants viewed semantically consistent or inconsistent objects within a scene; in Experiment 1, these objects were task-irrelevant, while in Experiment 2, they were directly relevant for behavior. In both experiments, we found reliable and comparable N300/400 differences between consistent and inconsistent scene-object combinations. To probe the quality of object representations, we performed multivariate classification analyses, in which we decoded the category of the objects contained in the scene. In Experiment 1, in which the objects were not task-relevant, object category could be decoded from ~100 ms after the object presentation, but no difference in decoding performance was found between consistent and inconsistent objects. In contrast, when the objects were task-relevant in Experiment 2, we found enhanced decoding of semantically consistent, compared with semantically inconsistent, objects. These results show that differences in N300/400 components related to scene-object consistency do not index changes in cortical object representations but rather reflect a generic marker of semantic violations. Furthermore, our findings suggest that facilitatory effects between objects and scenes are task-dependent rather than automatic.
Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review
Authors: Takahashi Kazuya , Khwaja Iman Geelani , Schreyer Jocelyn Rachel , Bulmer David , Peiris Madusha , Terai Shuji , Aziz Qasim 
Published: November 2021

AbstractPatients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain–gut axis, such as peripheral and central sensitization, altered sympatho-vagal balance, hypothalamic–pituitary–adrenal axis activation, and psychosocial factors, play a significant role in the development of post-inflammatory pain. A comprehensive study investigating the interaction between multiple predisposing factors, including clinical psycho-physiological phenotypes, molecular mechanisms, and multi-omics data, is still needed to fully understand the complex mechanism of post-inflammatory pain. Furthermore, current treatment options are limited and new treatments consistent with the underlying pathophysiology are needed to improve clinical outcomes.
Reinterventions and new aortic events after aortic surgery in Marfan syndrome
Authors: Toolan Caroline , Oo Shwe , Shaw Matthew , Field Mark , Kuduvalli Manoj , Harrington Deborah , Nawaytou Omar 
Published: November 2021

Abstract

OBJECTIVES
Pre-emptive strategies to manage the aortic complications of Marfan syndrome have resulted in improved life expectancy yet, secondary to the variation of phenotypic expression, anticipating the risk and nature of future aortic events is challenging. We examine rates of new aortic events and reinterventions in a Marfan cohort following initial aortic presentation.

METHODS
Retrospective cohort study of Marfan patients with aortic pathology presenting to our institution 1998–2018. Patients were grouped according to index event: aortic dissection or root aneurysm. Patients with aortic dissection were classified according to Debakey criteria. Incidence of new aortic events and frequency of reintervention were analysed.

RESULTS
One hundred and twenty-six aortic procedures were performed in 74 Marfan patients with a median follow-up of 7 years. Forty-seven patients had an index event of root aneurysm and 27 had aortic dissection. Following operative intervention in the aneurysm group, 7 patients developed Debakey III dissections raising the overall number of patients who developed dissection within this cohort to 34. Reinterventions were more frequent in the dissection group with full replacement of the native aorta in 5 patients.

CONCLUSIONS
After operative intervention on the proximal aorta, a proportion will develop distal pathology. A greater focus on factors contributing to future events, such as mapping genotypes to clinical course, may lead the way for targeted operative techniques and surveillance.
Perceived personal risk and vulnerability in recognizing and responding to symptoms of acute coronary syndrome: an integrative review
Authors: Blakeman John R , Prasun Marilyn A 
Published: November 2021

Abstract

Background
Simply knowing the common symptoms of acute coronary syndrome (ACS) is not sufficient to ensure prompt care-seeking when these symptoms occur. Factors other than symptom knowledge contribute to prompt care-seeking behaviours and correct symptom attribution to the heart.

Objectives
To explore how perceived personal risk and perceived personal vulnerability towards ACS affect a person’s ACS symptom recognition and attribution and also how this perception affects a person’s response to ACS symptoms.

Design
An integrative review, using Whittemore and Knafl’s approach.

Data sources
PubMed, Academic Search Complete, CINAHL Complete, APA PsycINFO, and APA PsycARTICLES

Eligibility criteria for study selection
We included studies that (i) were original human-subjects research or secondary analyses of human-subjects research, (ii) provided information about how perceptions of risk or perceptions of vulnerability towards ACS or heart disease affect symptom recognition, attribution, and/or response to symptoms, and (iii) were published in English.

Results
Thirteen articles were included. Studies were conducted in nine different countries and were descriptive or exploratory in nature. The existing evidence suggests that perceived personal risk or vulnerability towards heart disease may promote earlier care-seeking for ACS symptoms and facilitates attribution of symptoms to the heart.

Conclusion
The designs of the included studies limit causal attribution, and additional prospective and intervention-based research is needed to determine how perceived risk/vulnerability may affect care-seeking and ACS symptom attribution. Increasing perceptions of vulnerability towards heart disease may reduce care seeking delay.