bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of content trimming iPhone 12 Pro Max video files in iOS 14
Authors: Koenig Bruce E. , Lacey Douglas S. 
Published: August 2021

AbstractIn this audio/video authenticity research project, 44 original MOV files were produced on an Apple iPhone 12 Pro Max mobile device, running the iOS 14.2.1 operating system, in all available video formats and at four different nominal recording lengths. Each of the original files was then trimmed, using the Apple Photos app, in three different ways: deleting a portion of the beginning, a portion of the end, and portions of both the beginning and end. These 176 original and trimmed files were transferred to a laboratory computer and the footer and other metadata were analyzed with a hex editor. This analysis revealed that the trimmed recordings could be differentiated from the originals; that the iPhone model and the iOS operating system version could be identified; that important recording dates and times can be determined; and that the type of trimming, in some cases, could be determined.
Effects of mobile mindfulness on emergency department work stress: A randomised controlled trial
Authors: Xu Hui (Grace) , Eley Robert , Kynoch Kathryn , Tuckett Anthony 
Published: August 2021

AbstractObjectiveHigh‐occupational stress among ED staff has a detrimental impact on both staff wellness and patient care. The objective of the study is to determine whether 4 weeks of smartphone app‐guided mindfulness practice reduces stress levels of ED staff.MethodsThis two‐arm randomised controlled trial was conducted in two Australian EDs in 2019–2020. Eligible participants were randomly assigned (1:1) to either an App group or a Wait to Treat group to practice daily 10 min app‐guided mindfulness for 4 weeks. Online surveys were collected for both groups at three time periods: before (T1), immediately after (T2) and 3 months after cessation (T3). Then the Wait to Treat group received the same intervention, followed by surveys immediately after the intervention (T4) and 3 months later (T5). Primary outcome was measured using the Perceived Stress Scale. Secondary outcomes were measured using the Maslach Burnout Inventory (three subscales: emotional exhaustion, depersonalisation and personal accomplishment), Mindfulness Attention Awareness Scale and Warwick‐Edinburgh Mental Well‐being Scale. Both intention‐to‐treat and per‐protocol analysis were performed. Repeated measurement data were analysed by the linear mixed model.ResultsOf 148 enrolled participants 98 completed all the surveys, but only half (48%) reported continuous use of the app. Based on the results of the intention‐to‐treat analysis, there was a statistically significant improvement of perceived stress levels (F = 15.70, P < 0.001), all three components of burnout (emotional exhaustion [F = 14.22, P < 0.001], depersonalisation [F = 3.62, P = 0.030], personal accomplishment [F = 7.51, P < 0.001]), mindfulness (F = 8.83, P < 0.001) and wellbeing levels (F = 10.71, P < 0.001) from pre‐intervention to 3 months later with small effect sizes.ConclusionResults of the present study demonstrate that brief mindfulness training via innovative digital technology had a small positive effect in improving emergency staff stress, burnout, mindfulness and wellbeing.
Renal replacement therapy for critically ill patients with COVID‐19‐associated acute kidney injury: A review of current knowledge
Authors: Shemies Rasha Samir , Nagy Eman , Younis Dalia , Sheashaa Hussein 
Published: August 2021

AbstractThe outbreak of coronavirus disease 2019 (COVID‐19) has rapidly evolved into a global pandemic. A significant proportion of COVID‐19 patients develops severe symptoms, which may include acute respiratory distress syndrome and acute kidney injury as manifestations of multi‐organ failure. Acute kidney injury (AKI) necessitating renal replacement therapy (RRT) is increasingly prevalent among critically ill patients with COVID‐19. However, few studies have focused on AKI treated with RRT. Many questions are awaiting answers as regards AKI in the setting of COVID‐19; whether patients with COVID‐19 commonly develop AKI, what are the underlying pathophysiologic mechanisms? What is the best evidence regarding treatment approaches? Identification of the potential indications and the preferred modalities of RRT in this context, is based mainly on clinical experience. Here, we review the current approaches of RRT, required for management of critically ill patients with COVID‐19 complicated by severe AKI as well as the precautions that should be adopted by health care providers in dealing with these cases. Electronic search was conducted in MEDLINE, PubMed, ISI Web of Science, and Scopus scientific databases. We searched the terms relevant to this review to identify the relevant studies. We also searched the conference proceedings and ClinicalTrials.gov database.
Peat Accumulation and Early Carboniferous Environments of the Kizel Coal Basin, the Urals, Russia
Authors: NAUGOLNYKH Serge V. 
Published: August 2021

AbstractThe lithological and geochemical composition and conditions of formation of the coal‐bearing deposits of the Kizel Coal Basin in the Perm region of the Urals (central Russia) are described using the two most representative sections, Gubakha–Stary Most and Krestovaya Mountain, based on a detailed “layer‐by‐layer” technique. Brief characteristics of the Lower Carboniferous paleosols from fossil paleosol (FPS‐) profiles of the studied region are given. Special attention is paid to the parent vegetation of the coal‐forming processes, based on an analysis of both plant macrofossils and palynoflora. The peat accumulation in conditions of permanent incoming of clastic material from the Paleo‐Urals to the Kizel Basin was probably effective only in more or less stable environments, when the accumulated organic matter produced by plant mortmass was not dissolved by clastic particles. Thus, the conditions of coal‐forming are reconstructed as a forest swamp, where the main dominants are represented by lycopodiopsids of the order Lepidodendrales, predominantly Lepidodendron veltheimii. These plants in particular were the source of the initial organic matter for the peat (and later coal) of the Kizel Coal Basin.
Geochemical and Boron Isotopic Evidence that Tourmaline Records Country Rock Assimilation of Leucogranites in the Himalayan Orogen
Authors: HU Guyue , GAO Li'e , ZENG Lingsen , LI Yike 
Published: August 2021

AbstractTourmaline geochemical and boron (B) isotopic compositions in two‐mica granites (TMG), tourmaline‐bearing leucogranites (Tou‐LG), tourmalites and metapelites from the Gyirong–Malashan areas of the Himalayan orogen provide evidence for country rock assimilation during the intrusion of Himalayan leucogranite. The schorls in Gyirong leucogranitic plutons show low contents of MgO (0.238%–1.160%) and δ11B values (–12.1‰––11.2‰), while dravites gathered in the contact zone between the leucogranitic veins and metapelites show high contents of MgO (4.815%–6.755%) and δ11B values (–10.7‰––9.3‰). This geochemical and isotopic variation of tourmalines can also be identified in the Malashan gneiss dome. As a result, three types of tourmaline were identified in the Himalayan orogen: (1) Tou‐I in the TMG and Tou‐LG, which is the most common tourmaline type of schorl; (2) Tou‐II (dravite and high‐Mg schorl) in the Tou‐LG and tourmalite at the margins of the leucogranite; and (3) Tou‐III (mainly dravite, with minor high‐Mg schorl) in metapelites of the High Himalayan Crystalline Sequence. The lenses and veins of Tou‐LG may have experienced metasomatism and assimilation as a result of interaction with the High Himalayan Crystalline Sequence metasedimentary country rocks, which can be traced by the geochemical and isotopic characteristics of the tourmaline therein.
Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases
Authors: Mitsumura Takahiro , Kumaki Yuichi , Takahashi Kenta , Matsudera Shotaro , Sakakibara Rie , Honda Takayuki , Ishizuka Masahiro , Iijima Yuki , Shirai Tsuyoshi , Okamoto Tsukasa , Tateishi Tomoya , Sakashita Hiroyuki , Miyake Satoshi , Ikeda Sadakatsu , Miyazaki Yasunari 
Published: August 2021

AbstractOf the 80 solid tumor cases in which liquid biopsy (LB) was performed using Guardant360 in the PROFILE study, nine were lung cancer cases. Here, we review three cases in which LB was useful in diagnosing ALK fusion‐positive lung cancer, selecting sequential ALK‐tyrosine kinase inhibitors, confirming uncommon EGFR mutations, and receiving biomarker‐compatible therapy.
Antimicrobial action, cytotoxicity, calcium ion release, and pH variation of a calcium hydroxide‐based paste associated with Myracrodruon urundeuva Allemão extract
Authors: Krüger Helington Castro , Francio Jordano , Silva Arthur Sorgatto da , Oliveira Gabriela Silva Neubern de , Brancher João Armando , Dantas Letícia Ramos , Oliveira Rodrigo Cardoso de , Tuon Felipe Francisco , Carneiro Everdan 
Published: August 2021

AbstractThe extract of Myracrodruon urundeuva Allemão (aroeira), as a vehicle, associated with calcium hydroxide (CH) paste was evaluated based on cell viability, antimicrobial action, calcium ion release, and pH variation. Calcium hydroxide with propylene glycol was used as control. The pH variation was measured at 3, 24, 72, 168, 140, 360, and 720 h and calcium ion release was measured on days 7, 15, and 30. Cell viability was assessed with NIH/3T3 cells using MTT and crystal violet assays, after 24, 48, and 72 h. Antibacterial activity was determined by the disc diffusion method, while microbial reduction (Enterococcus faecalis) was evaluated using the time–kill test. The CH paste formulated with aroeira showed antibacterial activity against Enterococcus faecalis and further did not interfere with pH, calcium ion release, or cell viability; moreover, the formulation had antimicrobial activity and could serve as a vehicle for CH paste.
Algorithmic intraocular lens power calculation formula selection by keratometry, anterior chamber depth and axial length
Authors: Kim Jung Wan , Eom Youngsub , Yoon Eun Gyu , Choi Young , Song Jong Suk , Jeong Ji Won , Park Seh Kwang , Kim Hyo Myung 
Published: August 2021

AbstractPurposeTo compare the prediction accuracy of algorithmic intraocular lens (IOL) power calculation formula selection method using conventional formulas (Haigis, Hoffer Q, Holladay 1, SRK/T and/or Barrett Universal II) based on keratometry (K), anterior chamber depth (ACD) and axial length (AL).MethodsA total of 1653 patients (1653 eyes) implanted with Tecnis ZCB00 IOL during cataract surgery were enrolled in this study. Intraocular lens (IOL) power calculation formulas with a small absolute value in the sum of the area under the curve measured by K, ACD and AL subgroup were selected to calculate IOL power in the relevant biometry subgroup. The median absolute error (MedAE) calculated by the Haigis, Hoffer Q, Holladay 1, SRK/T and Barrett Universal II formulas individually was compared to that calculated by the algorithmic selection method using four formulas, Haigis, Hoffer Q, Holladay 1 and SRK/T, or five formulas when Barrett is included.ResultsThe MedAE was 0.27 D in the Haigis, 0.30 D in the Hoffer Q, 0.27 D in the Holladay 1, 0.29 D in the SRK/T and 0.26 D in the Barrett Universal II formulas. The MedAEs determined by the algorithmic selection method using four (019 D) and five (0.21 D) formulas were significantly lower than those by the conventional IOL power calculation formulas.ConclusionsThe IOL power calculation formula selection method by biometry subgroup combined with biometric parameters K, ACD and AL may offer a more superior postoperative refractive error prediction in cataract surgery.
Sing4Health: Randomised controlled trial of the effects of a singing group program on the subjective and social well‐being of older adults
Authors: Galinha Iolanda Costa , García‐Martín Miguel Ángel , Lima Maria Luísa 
Published: August 2021

AbstractGroup singing may be an optimal intervention strategy to promote active ageing and well‐being; however, evidence with experimental validity is scarce. This study aims to fill this gap by analysing the effects of a 34‐session singing group programme (SGP) on participants' subjective and social well‐being and the mediating roles of social identification with the singing group and of self‐esteem. An RCT with intervention (n = 89) and active waiting‐list control (n = 60) conditions was conducted, and a mixed method quantitative and qualitative data collection and analysis were performed. Participants were mostly elderly day‐care centre users (M = 76.66 years old; SD = 8.79) with low average levels of education and income. Structured measures of life satisfaction, positive and negative affect, self‐esteem, loneliness, social identification and social well‐being were collected, as well as interviews on the perceived benefits of participating in the SGP. Results showed significant effects of the SGP on the positive affect, social well‐being and marginally on the self‐esteem of the participants. The observed effects were sustained at the follow‐up. Qualitative analysis corroborated the quantitative results. Mediation analysis showed indirect effects of social identification with the singing group on loneliness and social identification with the social care institution group; and of self‐esteem on positive and negative affect.
Editorial: central obesity is a risk factor for hepatocellular carcinoma in Asian patients with chronic hepatitis B on anti‐viral therapy
Authors: Yip Terry Cheuk‐Fung , Wong Vincent Wai‐Sun 
Published: August 2021

LINKED CONTENTThis article is linked to Fan et al and Fan & Hou papers. To view these articles, visit https://doi.org/10.1111/apt.16469 and https://doi.org/10.1111/apt.16548
Editorial: does anti‐TNF “treatment persistence” always equate to “effective treatment”? Only objective disease assessments can answer the question
Authors: Srinivasan Ashish , van Langenberg Daniel R. 
Published: August 2021

LINKED CONTENTThis article is linked to Blesl et al papers. To view these articles, visit https://doi.org/10.1111/apt.16478 and https://doi.org/10.1111/apt.16535
Editorial: when to start carvedilol in cirrhosis—time to reconsider? Authors' reply
Authors: Wijarnpreecha Karn , Li Fang , Taner C. Burcin , Yang Liu , Tao Cui 
Published: August 2021

LINKED CONTENTThis article is linked to Wijarnpreecha et al and Gillespie & Hayes papers. To view these articles, visit https://doi.org/10.1111/apt.16490 and https://doi.org/10.1111/apt.16512
Inhibition of DNA methylation de‐represses peroxisome proliferator‐activated receptor‐γ and attenuates pulmonary fibrosis
Authors: Wei Ai , Gao Qi , Chen Fang , Zhu Xiaobo , Chen Xingren , Zhang Lijun , Su Xin , Dai Jinghong , Shi Yi , Cao Wangsen 
Published: August 2021

Background and PurposeDevelopment of pulmonary fibrosis is associated with altered DNA methylation modifications of fibrogenic gene expression. However, their causal relationships and the underlying mechanisms remain unclear. This study investigates the critical role of DNA methylation aberration‐associated suppression of peroxisome proliferator‐activated receptor‐γ (PPARγ) in pulmonary fibrosis.Experimental ApproachExpression of PPARγ and bioactive DNA methyltransferases (DNMTs) and PPARγ promoter methylation status were examined in fibrotic lungs of idiopathic pulmonary fibrosis (IPF) patients and bleomycin (Blm)‐treated mice. DNA demethylating agent 5‐aza‐2′‐deoxycytidine (5aza) and glycyrrhizic acid (GA) derived from medicinal plant were assessed for their PPARγ de‐repression and anti‐pulmonary fibrosis activities. PPARγ knockout mice were created to determine the critical role of PPARγ in this protection.Key ResultsLung PPARγ expression was markedly suppressed in IPF patients and Blm mice, accompanied by increased DNMT 1/DNMT3a and PPARγ promoter hypermethylation. Administration of 5‐aza and GA similarly demethylated PPARγ promoter, restored PPARγ loss and alleviated fibrotic lung pathologies, including structural alterations and adverse expression of fibrotic mediators and inflammatory cytokines. In cultured lung fibroblasts and alveolar epithelial cells, GA alleviated PPARγ–mediated suppression of fibrosis in a gain of DNMT‐sensitive manner, and in PPARγ knockout mice, the anti‐fibrotic effects of 5aza and GA were significantly reduced, suggesting that PPARγ is a critical mediator of epigenetic pulmonary fibrogenesis.Conclusion and ImplicationsAberrant DNMT1/3a elevations and the resultant PPARγ suppression contribute significantly to the development of pulmonary fibrosis, and strategies targeting DNMT/PPARγ axis with synthetic or natural compounds might benefit patients with pulmonary fibrotic disorders.
Laparoscopic versus open resection in locally advanced rectal cancers: a propensity matched analysis of oncological and short‐term outcomes
Authors: Sasi Sajith , Kammar Praveen , Masillamany Sivasanker , de' Souza Ashwin , Engineer Reena , Ostwal Vikas , Saklani Avanish 
Published: August 2021

AbstractAimThe aim was to compare oncological and short‐term outcomes between open and laparoscopic surgery in locally advanced rectal cancers.MethodsIt is a retrospective analysis conducted in a high volume tertiary centre. Matching was carried out for nine variables, including preoperative factors, neoadjuvant treatment and sphincter preservation.ResultsBoth the open and laparoscopic surgery arms had 239 patients each. The distributions of pretreatment MRI T3, T4, circumferential resection margin (CRM) positive tumours, neoadjuvant long‐course chemoradiation and sphincter preservation were 80.3%, 13.6%, 50%, 89% and 56.4% respectively. The mean number of nodes harvested (12.9 vs. 12.7, P = 0.716), pathological CRM positivity (6.3% in open vs. 5.4% in laparoscopic, P = 0.697) and distal resection margins were similar. The mean blood loss was higher in open surgeries (910 ml vs. 349 ml, P < 0.001). Anastomotic leaks and Clavien–Dindo Grade 3–4 complications were higher in the open arm than in the laparoscopy arm (5.9% vs. 1.7%, P = 0.024, and 12.5% vs. 6.7%, P = 0.015 respectively). The median postoperative hospital stay was significantly shorter in the laparoscopy arm (7 vs. 6, P = 0.015). In CRM positive and threatened cases, the measured outcomes were similar between the two groups except for blood loss which was significantly higher in the open surgery (872 vs. 379, P = 0.000).ConclusionsIn high volume centres, in the hands of experienced colorectal surgeons, laparoscopic rectal surgery is oncologically safe in locally advanced rectal cancers and has lesser morbidity and shorter hospital stay than open surgery. In CRM positive and threatened cases the laparoscopic surgery showed less blood loss compared to open surgery, while other outcome measures were similar to open surgery.
Pharmacokinetic and pharmacodynamic bioequivalence of biosimilar MYL‐1601D with US and European insulin aspart in healthy volunteers: A randomized, double‐blind, crossover, euglycaemic glucose clamp study
Authors: Hövelmann Ulrike , Raiter Yaron , Chullikana Anoop , Liu Mark , Donnelly Charles , Lawrence Tracey , Sengupta Nilanjan , CL Gopu , Ranganna Gopinath , Barve Abhijit 
Published: August 2021

AbstractAimTo evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) bioequivalence (BE) of MYL‐1601D biosimilar with originator, NovoLog (Ref‐InsAsp‐US), and NovoRapid (Ref‐InsAsp‐EU).Materials and MethodsThis was a double‐blind, randomized, crossover study that enrolled 71 healthy subjects to receive a single subcutaneous dose (0.2 U/kg) of each formulation under automated euglycaemic clamp conditions (ClampArt, level 81 mg/dL, duration 12 hours postdose). Primary PK endpoints were area under the plasma insulin aspart concentration‐time curve from 0 to 12 hours (AUC0‐12h) and maximum plasma insulin aspart concentration (Cmax). Primary PD endpoints were area under the glucose infusion rate (GIR) time curve from 0 to 12 hours (AUCGIR0‐12h) and maximum GIR (GIRmax). Insulin aspart in plasma was quantified using immunoaffinity purification followed by ultraperformance liquid chromatography and tandem mass spectrometric detection. The pairwise comparisons of geometric least square mean (LS‐mean) ratio for a 90% confidence interval (CI) of primary PK, and 90% CIs (MYL‐1601D vs. Ref‐InsAsp‐US) and 95% CIs (MYL‐1601D vs. Ref‐InsAsp‐EU) of primary PD variables, were to be within 80% to 125% to show BE.ResultsMYL‐1601D showed PK BE to both Ref‐InsAsp‐US (AUC0‐12h geometric LS‐mean ratio 102.17, 90% CI [100.26; 104.11]; Cmax 106.13 [100.71; 111.85]) and Ref‐InsAsp‐EU (AUC0‐12h 101.84 [100.04; 103.67]; Cmax 105.74 [101.09; 110.60]). Likewise, MYL‐1601D showed PD BE to Ref‐InsAsp‐US (AUCGIR_0‐last 99.93; 90% CI [95.74; 104.30]; GIR_max 100.12 [94.46; 106.12]) and Ref‐InsAsp‐EU (AUCGIR_0‐last 96.42; 95% CI [91.17; 101.98]; GIR_max 95.10 [89.37; 101.19]). All three insulin aspart products were well tolerated.ConclusionMYL‐1601D showed BE to Ref‐InsAsp‐US and Ref‐InsAsp‐EU with a comparable safety profile.
Exploring the implications of cloud‐based enterprise resource planning systems for public sector management accountants
Authors: Carlsson‐Wall Martin , Goretzki Lukas , Hofstedt Jesper , Kraus Kalle , Nilsson Carl‐Johan 
Published: August 2021

AbstractBased on a case study of a large Swedish local government municipality, we explored the extent to which a cloud‐based enterprise resource planning (CERP) system enabled the role performance of public sector management accountants. Our findings suggest that the CERP system enabled central management accountants to mobilize their specific expertise because it eliminated manual work, increased transparency, and made them feel more comfortable with the numbers. However, the less flexible features of a CERP system provided by external vendors, such as limited customization, posed a challenge for the local management accountants serving the different needs of a diverse range of managers and business units. Looking at the different attitudes that central and local management accountants developed toward the CERP system, we found that although both focal groups in our analysis belonged to the same occupation, they framed the role of technology differently. Although local management accountants framed it as a tool that should enable them to draw on their local expertise to produce tailor‐made information for their local units, central management accountants saw the CERP system as a tool that allowed them to consume prefabricated “high‐quality” information to assure efficient and risk‐free accounting processes throughout the entire organization. Given this, cloud technology constitutes a risk that accounting and control processes become unduly inflexible and cumbersome at the local level. Coping with an inflexible cloud‐based system may therefore add to the list of challenges that public sector management accountants experience when trying to be(come) business partners.
Fatal remedies. How dealing with policy conflict can backfire in a context of trust‐erosion
Authors: Wolf Eva Elizabeth Anne , Dooren Wouter Van 
Published: August 2021

AbstractThis article investigates the relationship between policy conflict and trust‐erosion. It concludes that in a context of trust‐erosion, practices to deal with conflict may backfire and lead to further conflict escalation. The article draws on an in‐depth analysis of 32 interviews with key actors in the conflict over a contested multibillion‐euro highway project in Antwerp (Belgium). It concludes that while all actors draw on the policy repertoire of “managing public support” to explain the conflict, their perspectives of what it means for a policy to have public support differ. Practices to “manage public support” that made sense from one perspective, contributed to the erosion of trust from those holding a different perspective, thus further escalating the conflict. Practices intended to end conflict proved to be fatal remedies.