bluuebunny/crossref_metadata_2025_split huggingface dataset:
The social life of creative methods: Filmmaking, fabulation and recovery
Authors: Vitellone Nicole , Theodoropoulou Lena , Manchot Melanie 
Published: December 2024

AbstractIn this article we consider the theoretical and methodological implications of Deleuzian fabulation for research on recovery from drugs and alcohol as an alternative way of making and doing methods in sociology. The article draws on data produced as part of an ongoing interdisciplinary research collaboration, begun in 2019, with the visual artist and filmmaker Melanie Manchot, social scientists Nicole Vitellone and Lena Theodoropoulou, and people in recovery from drugs and alcohol engaged in the production of Manchot’s first feature film STEPHEN. This project attends to the methodological practice of filmmaking as a way of thinking with and alongside colleagues from divergent disciplines about the role of methods, concepts and practices for confronting and resisting processes of stigmatisation. Investigating the research participants’ engagement with Manchot’s filmmaking practices in STEPHEN as a way to tell stories otherwise, our goal is to engage the social life of creative methods and in doing so, propose an alternative narrative of recovery. In this investigation, we use the term fabulation as developed by Deleuze. In Cinema II, Deleuze makes a distinction between the cinema of reality, where storytelling derives from the camera’s objective gaze and a given character’s subjective actions, and cinema verité where the boundaries between fiction and reality are blurred. In cinema verité, the camera is not an objective observer but an active producer that keeps reminding the viewer that the on‐screen characters are neither fully real, nor fictional. Attending to Deleuze’s description of fabulation as it emerges through this process of challenging the existence of ‘real’ identities in cinema, and beyond, we investigate the use of cinematic devices and fabulative processes of filmmaking in the production of STEPHEN. In doing so, the article develops a methodological account of the activity of fabulation as a material and embodied practice that resists processes of stigmatisation. Through this interdisciplinary project, we propose a new arts‐based research agenda which points to the ways in which fabulation as a minor mode of recovery concerns an engagement with the creation of a people to come.
Beverages developed from pseudocereals (quinoa, buckwheat, and amaranth): Nutritional and functional properties
Authors: Li Hang , Zhu Fan , Li Guantian 
Published: December 2024

AbstractThe rising global demand for nutritious, sustainable, and plant‐based beverages has catalyzed interest in pseudocereal‐based products, offering an innovative alternative to traditional cereals. Pseudocereals such as quinoa, buckwheat, and amaranth are valued for their exceptional nutritional profiles, including high‐quality proteins, dietary fibers, and bioactive compounds. This review explores the development of pseudocereal‐based beverages, emphasizing their potential as milk alternatives, fermented drinks, and beer products. The fermentation process enhances their nutritional value, bioavailability, and sensory attributes, while also reducing antinutritional factors like phytates and saponins. Moreover, these beverages exhibit promising health benefits, including antioxidant, hypoglycemic, antidiabetic, and antihypertensive effects. This review provides a comprehensive evaluation of pseudocereal‐based beverages from regulatory considerations to production processes, highlighting the potential of these ancient grains in reshaping the beverage industry while addressing modern nutritional needs. Future research directions on pseudocereal‐based beverages are also suggested.
An overview of the nutritional quality and health benefits linked to the world diversity of citrus fruits/juices
Authors: Dhuique‐Mayer Claudie , Servent Adrient 
Published: December 2024

AbstractCitrus juices represent a nutrient‐dense beverage due to the remarkable balance in their bioactive compounds (vitamins, minerals, dietary fibers, and phytochemicals such as flavonoids and carotenoids). This review aims to examine the nutritional quality and the health benefits of citrus juice consumption linked to the world diversity of citrus fruits. This work provides heterogenous data found on the main citrus bioactive compounds, especially carotenoids and flavonoids, which are difficult to correlate to particular geographic areas. Through an example of study, this work addresses the question of how and to what extent the content of citrus bioactive compounds is linked to the health benefits observed in humans. We explore through the more recent human clinical trials, the health effects of consuming citrus fruit or taking dietary supplements of bioactive compounds to prevent the exponential increase of world chronic diseases (type 2 diabetes, cardiovascular diseases, and obesity) and discuss the effects of dose. Finally, even if the data highlight the importance of geographical origin in accumulation of carotenoids or flavonoids from different Citrus species, the difference of content in front of the complex human metabolism of their absorption has lesser consequences for health than the fact of consuming citrus or not. The citrus health effect results in a synergistic action of numerous phytochemicals whose targeted health benefits vary depending more on the diversity of Citrus species than their geographic origin. Therefore, the use of the diversity of Citrus species could be an interesting approach to providing functional food.
Construction of chitosan hydrochloride‐carboxymethyl chitosan nanoparticles using anti‐solvent method for the co‐delivery of puerarin and resveratrol
Authors: Wang Zi‐Xuan , Wang Yi‐Zhen , Chen Xiao , Wu An‐Ji , Liu Wei , Li Hui‐Jing 
Published: December 2024

AbstractThe applications of resveratrol (RES) and puerarin (PUE) with notable physiological functions are greatly limited in functional food and pharmaceutical industries due to their poor water solubility and chemical instability. Accordingly, co‐loading of RES and PUE into chitosan‐based nanoparticles (NPs) is performed here by an anti‐solvent method to improve their bioavailability. The fabricated NPs at 8:1 mass ratio of carboxymethyl chitosan (CMC) to chitosan hydrochloride (CHC) with the particle size of 375.1 nm and zeta potential of +36.5 mV showed encouraging encapsulation efficiency and loading capacity at 85.2% (RES), 89.5% (PUE), and 15.5%. The microstructure of core–shell CMC–CHC was confirmed through dynamic light scattering and transmission electron microscopy. Molecular docking and storage stability indicating the more beneficial encapsulation of chitosan derivatives to PUE in comparison to RES. Cellular antioxidant activity experiments showed that the bioactivities of PUE/RES after loading with 20 and 40 mg·mL−1 were improved by 13.2% and 18.5%, respectively, with respect to free ones. Therefore, RES/PUE‐loaded CHC–CMC NPs were successfully prepared in this study, thus significantly improving the RES and PUE bioavailability and promoting their applications in functional food and pharmaceutical industries.
Composition, microstructure, rheology, and meltdown behavior of commercial nondairy frozen desserts
Authors: Freire Dieyckson O. , Atik Didem Sözeri , Gladem Payton M. , Rankin Scott A. , Hartel Richard W. 
Published: December 2024

AbstractThe demand for nondairy and plant‐based products has increased, but there is still a need for more information about and improvement in these products, especially when it comes to frozen desserts. Similar to ice cream, which simultaneously is an emulsion, dispersion, and foam, nondairy frozen desserts also have a complex structure. As a starting point, 15 commercial nondairy frozen desserts, marketed as offering an ice cream‐like experience, were purchased and evaluated for compositional, physical, structural, rheological, and meltdown properties. The correlations between the parameters of these characteristics were also studied. The parameters with the greatest variability in percentage terms for each property after melt‐down were fat content ranging from 3.8% to 18.6%, surface tension from 26.4 to 45.4 mN·m−1, fat destabilization from 3.6% to 94.4%, yield stress from 0.0 to 25.2 Pa, and final height from 0% to 77.3%. Interestingly, the maximum overrun found was about 82%, considered low compared to economy dairy ice creams. The fat content was the most significant parameter that influenced drip‐through rate, height change rate, and final height. Additionally, yield stress was the only rheological parameter that correlated with the meltdown behavior, which affected only one of them, the induction time. Therefore, in the meltdown profile, the lag phase was driven by yield stress, while the fast‐melting phase and the plateau phase were influenced by the fat content. Moreover, four samples presented uncommon drip‐though curves, which were visually recorded. This study offers a baseline understanding of the compositional, structural, rheological, and melting characteristics of commercial nondairy frozen desserts available in the United States.Practical ApplicationThe compositional, microstructural, rheological, and meltdown characteristics of nondairy frozen desserts available in the US market were evaluated. The information can be used for industry research and development, understanding the challenges, and advancing knowledge regarding nondairy frozen desserts.
Preservative effects and mechanism of condensed tannins from Cercis chinensis Bunge leaves on fresh‐cut lotus root
Authors: Jian Yanbo , Xiao Xiaoxue , Qian Xufeng , Liang Meng , Chen Hui , Song Wei 
Published: December 2024

AbstractThis study aimed to investigate the potential of condensed tannins isolated from Cercis chinensis Bunge leaves as natural preservatives for fruits and vegetables. The research demonstrated that C. chinensis leaves condensed tannins (CLCT) significantly delay the browning process and reduce nutritional loss in fresh‐cut lotus roots. Prodelphinidins were identified as the primary component of CLCT through electrospray ionization mass spectrometry and high‐performance liquid chromatography analyses, with minor proportions of procyanidins and high levels of galloylation. The structural units predominantly consisted of (epi)gallocatechin. CLCT exhibited substantial inhibitory activity against tyrosinase, which may involve interactions with copper ions at the enzyme's active site and alterations in enzyme conformation, resulting in reversible inhibition. Additionally, CLCT displayed remarkable antioxidant and antibacterial properties, effectively scavenging 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2'‐ azinobis (3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium salt (ABTS) radicals and significantly inhibiting the growth of Pseudomonas aeruginosa and Staphylococcus aureus. Overall, the potential of CLCT as a natural preservative and tyrosinase inhibitor underscores its promising application in preserving fruits and vegetables.
Cytotoxicity and Bone Biocompatibility of the C‐Root SP Experimental Root Canal Sealer
Authors: Yang Xiliang , Xia Lingyun , Chen Yongji , Jiang Lei , Zheng Tianxia , Bai Yuhong 
Published: December 2024

ABSTRACTThis study evaluated the cytotoxicity and biocompatibility of a new strontium silicate‐based root canal sealer (C‐Root SP), in comparison with those of iRoot SP and AH plus. The sealer extract was diluted to the concentrations of 100%, 75%, 50%, and 25%. L929 cells were cultured for 24 h, and the absorbance value was determined. Two‐way analysis of variance (two‐way ANOVA) and sealers were implanted in the tibia of Sprague–Dawley (SD) rats, At 2, 6, and 12 weeks, rats were euthanised. The tissue reaction was evaluated by HE staining. The least significant difference (LSD) t‐test and Kruskal–Wallis test were used. The cytotoxicity of C‐Root SP and iRoot SP was found to be less than that of AH plus. At 12 weeks, new bone formation was induced around C‐Root SP and iRoot SP sealer, but minimal evidence of bone formation was found in AH plus. C‐Root SP has low cytotoxicity and superior biocompatibility.
Normative prospective data on automatically quantified retinal morphology correlated to retinal function in healthy ageing eyes by two microperimetry devices
Authors: Birner Klaudia , Coulibaly Leonard M. , Schrittwieser Johannes , Steiner Irene , Mohamed Hamza , Schürer‐Waldheim Simon , Gumpinger Markus , Bogunovic Hrvoje , Schmidt‐Erfurth Ursula , Reiter Gregor S. 
Published: December 2024

AbstractPurposeThe relationship between retinal morphology, as assessed by optical coherence tomography (OCT), and retinal function in microperimetry (MP) has not been well studied, despite its increasing importance as an essential functional endpoint for clinical trials and emerging therapies in retinal diseases. Normative databases of healthy ageing eyes are largely missing from literature.MethodsHealthy subjects above 50 years were examined using two MP devices, MP‐3 (NIDEK) and MAIA (iCare). An identical grid, encompassing 45 stimuli was used for retinal sensitivity (RS) assessment. Deep‐learning‐based algorithms performed automated segmentation of ellipsoid zone (EZ), outer nuclear layer (ONL), ganglion cell layer (GCL) and retinal nerve fibre layer (RNFL) from OCT volumes (Spectralis, Heidelberg). Pointwise co‐registration between each MP stimulus and corresponding location on OCT was performed via registration algorithm. Effect of age, eccentricity and layer thickness on RS was assessed by mixed effect models.ResultsThree thousand six hundred stimuli from twenty eyes of twenty patients were included. Mean patient age was 68.9 ± 10.9 years. Mean RS for the first exam was 28.65 ± 2.49 dB and 25.5 ± 2.81 dB for MP‐3 and MAIA, respectively. Increased EZ thickness, ONL thickness and GCL thickness were significantly correlated with increased RS (all p < 0.001). Univariate models showed lower RS with advanced age and higher eccentricity (both p < 0.05).ConclusionThis work provides reference values for healthy age‐related EZ and ONL‐thicknesses without impairment of visual function and evidence for RS decrease with eccentricity and increasing age. This information is crucial for interpretation of future clinical trials in disease.
How and When Does Unethical Pro‐Organizational Behavior Lead to Organizational Deviance? A Moderated Dual‐Path Model
Authors: Wang Taolin , Qu Hao , Zhang Guanglei , Zhou Hao , Chen Fengwen , Zhang Yong 
Published: December 2024

ABSTRACTPrevious research on the detrimental consequences of employees' unethical pro‐organizational behaviors (UPB) has been based mainly on cognitive dissonance theory. The authors suggest that moral disengagement theory and cognitive dissonance theory can be used to explain the negative effects of UPB. We conducted two studies, including a scenario experiment and a survey, to test the mediating roles of moral identity and moral disengagement and the moderating role of performance pressure in the relationship between UPB and organizational deviance. The results revealed that UPB impacts organizational deviance through moral identity and moral disengagement and that distinct psychological reactions are differentially moderated by performance pressure. Employees who face low levels of performance pressure are more receptive to the effects of moral identity; in contrast, employees who face high levels of performance pressure are more receptive to the effects of moral disengagement. The theoretical and managerial implications of this research are discussed.
Assessing student perceptions and use of instructor versus AI‐generated feedback
Authors: Er Erkan , Akçapınar Gökhan , Bayazıt Alper , Noroozi Omid , Banihashem Seyyed Kazem 
Published: December 2024

AbstractDespite the growing research interest in the use of large language models for feedback provision, it still remains unknown how students perceive and use AI‐generated feedback compared to instructor feedback in authentic settings. To address this gap, this study compared instructor and AI‐generated feedback in a Java programming course through an experimental research design where students were randomly assigned to either condition. Both feedback providers used the same assessment rubric, and students were asked to improve their work based on the feedback. The feedback perceptions scale and students' laboratory assignment scores were compared in both conditions. Results showed that students perceived instructor feedback as significantly more useful than AI feedback. While instructor feedback was also perceived as more fair, developmental and encouraging, these differences were not statistically significant. Importantly, students receiving instructor feedback showed significantly greater improvements in their lab scores compared to those receiving AI feedback, even after controlling for their initial knowledge levels. Based on the findings, we posit that AI models potentially need to be trained on data specific to educational contexts and hybrid feedback models that combine AI's and instructors' strengths should be considered for effective feedback practices.
Practitioner notesWhat is already known about this topic

Feedback is crucial for student learning in programming education.
Providing detailed personalised feedback is challenging for instructors.
AI‐powered solutions like ChatGPT can be effective in feedback provision.
Existing research is limited and shows mixed results about AI‐generated feedback.
What this paper adds

The effectiveness of AI‐generated feedback was compared to instructor feedback.
Both feedback types received positive perceptions, but instructor feedback was seen as more useful.
Instructor feedback led to greater score improvements in the programming task.
Implications for practice and/or policy

AI should not be the sole source of feedback, as human expertise is crucial.
AI models should be trained on context‐specific data to improve feedback actionability.
Hybrid feedback models should be considered for a scalable and effective approach.
Agonists of the opioid δ‐receptor improve irritable bowel syndrome‐like symptoms via the central nervous system
Authors: Yoshioka Toshinori , Kimiki Sayaka , Yamazaki Mayuna , Hamano Takumi , Ou Mizuki , Ode Yumi , Ehara Rui , Kajino Keita , Kasai Satoka , Yoshizawa Kazumi , Saitoh Tsuyoshi , Yamada Daisuke , Nagase Hiroshi , Saitoh Akiyoshi 
Published: December 2024

AbstractBackground and PurposeIrritable bowel syndrome (IBS) is a common condition that is challenging to treat, and novel drugs are needed for this condition. Previously, a chronic vicarious social defeat stress (cVSDS) mouse model exhibits IBS‐like symptoms. Also agonists of the opioid δ‐receptor exert anti‐stress effects in rodents with minimal adverse effects. Here, we evaluated the effects of δ‐receptor agonists on the IBS‐like symptoms in cVSDS mice.Experimental ApproachcVSDS mice (male C57BL/6J mice) were prepared following a 10‐day exposure to witness of social defeat stress. Subsequently, intestinal peristaltic motility and abdominal hyperalgesia were evaluated using the charcoal meal test (CMT) and capsaicin‐induced hyperalgesia test (CHT), respectively. Extracellular glutamate levels were measured using in vivo brain microdialysis. The drug was singly administrated 30 min before testing.Key ResultsIn cVSDS mice, systemic (10 mg kg−1) and intracerebroventricular (30 nmol) administration of a δ‐receptor agonist regulated intestinal peristalsis in the CMT and relieved abdominal pain in the CHT. Effects of systemic administration were blocked by intracerebroventricular injection of a δ‐receptor inhibitor. Local infusion of the δ‐receptor agonist (0.6 nmol) into the insular cortex improved cVSDS‐induced intestinal hypermotility. The in vivo brain microdialysis study showed that re‐exposure to VSDS elevated the extracellular glutamate levels in the IC, which was restored by the δ‐receptor agonist.Conclusions and ImplicationsWe propose that agonists of opioid δ‐receptors are potential drugs for the radical treatment of IBS because they can ameliorate IBS‐like symptoms via the CNS, specifically the insular cortex.
Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patients
Authors: Kaliki Swathi , Vempuluru Vijitha S. , Ahmad Alia , Berry Jesse L. , Diaz‐Coronado Rosdali , Eiger‐Moscovich Maya , Fabian Ido Didi , Grossniklaus Hans , Baker Hubbard G. , Mohammad Mona , Pe'er Jacob , Reddy M. Ashwin , Sagoo Mandeep S. , Shields Carol L. , Staffieri Sandra E. , Tanabe Mika , Ushakova Tatiana , Yousef Yacoub A. ,   High‐Risk Retinoblastoma Collaborative Study Group
Published: December 2024

ABSTRACTBackgroundTo evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race of origin in a global cohort of patients.MethodsRetrospective collaborative study of 1426 patients who underwent primary enucleation for retinoblastoma.ResultsPatients were grouped into Caucasians (n = 231, 16%), Asians (n = 841, 59%), Hispanics (n = 226, 16%), Arabs (n = 96, 7%) and Others (Africans, African Americans, Indigenous Australians; n = 32, 2%) cohorts. On histopathology, massive choroidal invasion was higher in Asians (30%) and Hispanics (26%) than Caucasians (15%, p < 0.001). Post‐laminar optic nerve invasion was higher in Asians (28%), Hispanics (20%) and Others (9%) than Caucasians (11%, p < 0.001). At a mean follow‐up of 41 months (median, 35 months; range, < 1–149 months), tumour recurrence and metastasis‐related death was higher in Hispanics (9% and 12%, respectively), Asians (4% and 13%, respectively) and Others (6% and 6%, respectively). Multivariate Cox proportional hazards analysis of outcomes based on race with 8th edition AJCC pT stage and adjuvant therapy as covariates revealed 6.8 times greater risk for orbital tumour recurrence in Hispanics compared to Caucasians (p = 0.010) and 3.2 times risk hazards for metastasis‐related death in Hispanics and Asians compared to Caucasians (p = 0.028 and p = 0.038, respectively).ConclusionThe histopathological features in primarily enucleated eyes with retinoblastoma vary with race. Despite adjusting for tumour staging and adjuvant treatment, race remains an independent predictor of outcomes, including orbital tumour recurrence and metastasis‐related death. A stringent follow‐up and a more aggressive treatment approach is recommended in Asians and Hispanics who manifest high‐risk histopathological features.