bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of association between MMP13 (rs3819089), ADAM12 (rs3740199-rs1871054) and ADAMTS14 (rs4747096) genotypes and advanced-stage knee osteoarthritis
Authors: Haberal Bahtiyar , Kaya Şimşek Ekin , Pınar Baysan Çebi Hatice , Tuç Özer , Verdi Hasibe , Belgin Ataç Fatma 
Published: July 2021

Objectives: The aim of this study was to investigate the relationship between MMP13 rs3819089, ADAM12 rs3740199 and rs1871054, and ADAMTS14 rs4747096 genotypes in patients with radiologically diagnosed knee osteoarthritis (OA).
Patients and methods: A total of 300 patients (68 males, 232 females; mean age: 61.6 years; range, 25 to 89 years) who were admitted to the orthopedics and traumatology clinic and diagnosed with knee OA according to the 2000 American College of Rheumatology (ACR) criteria between October 2018 and March 2019 were prospectively analyzed. Patients with Grades III-IV OA according to the Kellgren- Lawrence (K-L) grading system were included in the patient group (n=150) and those without radiological features of knee OA (K-L Grades I-II) were included in the control group (n=150) voluntarily. The presence of single nucleotide polymorphisms (SNPs) in the targeted genes in both groups was assessed by real-time polymerase chain reaction in the peripheral blood sample.
Results: The most common nucleotides in both the control and patient groups were CG for rs3740199 and CT for rs1871054 in the ADAM12 gene, and the most common nucleotides in alleles were GG for MMP13 rs3819089 and AA for ADAMTS14 rs4747096. No statistically significant relationship was detected between the gene polymorphisms and advanced OA.
Conclusion: The study results suggest that ADAM12 rs3740199 and rs1871054, MMP13 rs3819089, and ADAMTS14 rs4747096 polymorphisms have no relationship with knee OA susceptibility in the Turkish population. However, as this is the first study to investigate the relationship between the SNPs of ADAM12, ADAMTS14, and MMP13 genes and the development of OA in the Turkish population, it would contribute to our understanding of the molecular bases of OA.
The effect of the COVID-19 pandemic on orthopedic surgeries in a tertiary referral center
Authors: Kamacı Saygın , Göker Barlas , Çağlar Ömür , Atilla Bülent , Tokgözoğlu A. Mazhar 
Published: July 2021

Objectives: The aim of this study is to investigate the effect of the novel coronavirus-2019 (COVID-19) pandemic on the operational trends in the orthopedic surgery department of a tertiary referral center.
Patients and methods: A total of 305 orthopedic surgical procedures in 245 patients (136 males, 109 females; mean age: 34±26.6 years; range, 0 to 91 years) between March 16th and June 27th, 2020 were retrospectively analyzed. The same period of the year before including 860 procedures in 783 patients (364 males, 419 females; mean age: 33.6±25.8 years; range, 0 to 95 years) was also reviewed as a pre-pandemic control group. Patient demographics, surgical indications, COVID-19 polymerase chain reaction (PCR) test status, method of anesthesia, surgical subspecialties (trauma, sports, etc.), trauma mechanisms, and surgical priorities were evaluated. The pandemic and the pre- pandemic periods were compared.
Results: The rate of elective surgeries decreased compared to the previous year, and priority C type surgeries had the highest frequency (42.5%). Orthopedic trauma was the leading subspecialty with 91 (29.8%) cases and had a higher share, compared to the pre-pandemic period (17.0%). Hip fractures (18.7%) were the most common cause of trauma surgery, and simple falls (42.3%) composed the largest group of trauma mechanisms, which was similar to the pre-pandemic period (hip fractures, 13.6%; simple falls, 42.5%). The distribution of surgical urgency levels and subspecialties differed significantly between the pre-pandemic and pandemic periods (p<0.001). Post- hoc analysis of subspecialty distribution revealed a significant decrease in arthroplasty (p=0.002) and hand surgery (p<0.001), and a significant increase in trauma (p<0.001) and the “other” category (p<0.001).
Conclusion: Our experience in a tertiary referral center illustrated a shift toward performing emergent and urgent surgeries, when the severity of the outbreak increased. Prioritizing surgical urgencies during the outbreak changed the orthopedic surgery practice with an emphasis on trauma and oncology surgeries. Hip fractures were the most common cause of trauma surgery, and simple falls composed the largest group of trauma mechanisms.
The Shifting Sands of Happiness
Authors: Johnson Kirk , Garrido Heather , Gordon Alyssa , Perez Artemia , Uncango Amber 
Published: July 2021

Makalah ini berpendapat bahwa dorongan kekuatan kapitalisme di dunia modern dan gagasan bahwa kemakmuran dan kesuksesan terkait erat dengan pasar, pada dasarnya bertentangan dengan nilai-nilai dan tradisi budaya asli. Dengan fokus penelitian pada dua masyarakat pulau yaitu Guam dan Bali, kami menggali bagaimana kekuatan materialisme dan globalisasi modern yang didorong oleh filosofi individualisme, telah menantang budaya tradisional untuk melihat lebih dalam dan menemukan cara kreatif untuk mempertahankan nilai, pandangan hidup dan interaksi mereka tapi dengan tetap mengikuti kemajuan dunia modern. Penelitian ini menggali konsep “object of desire” atau “objek keinginan” dari perspektif dua budaya tersebut yaitu Chamoru dan Bali. Melalui wawancara mendalam yang dilakukan di Guam (Mikronesia) dan Bali (Indonesia) dengan para tokoh budaya, organisasi masyarakat, praktisi pembangunan dan seniman, kami belajar bagaimana masyarakat adat memahami dunia dan apa yang penting dalam hidup mereka, serta alat praktis apa yang digunakan untuk mengajar generasi berikutnya tentang di mana sumber kebahagiaan dan kepuasan sejati berada. Temuan kami menawarkan wawasan dan pemahaman yang bermanfaat bagi masyarakat global yang semakin hari menyadari bahwa penekanan pada pasar saat ini sebagai sumber kebahagiaan, tidaklah berkelanjutan dan bahwa pada kenyataannya penekanan ini malah menjadi penyebab begitu banyak penderitaan dan eksploitasi di dunia saat ini. Banyak jawaban atas tantangan yang kita hadapi saat ini baik.
ANALISIS RETURN ON INVESTMENT (ROI) UNTUK MENILAI KINERJA KEUANGAN PADA PT. MITRA INVESTINDO, Tbk.
Authors: Hardiansyah Dedy , Nurhayati Nurhayati 
Published: July 2021

The purpose of this study is to find out how much Return On Investment (ROI) is to assess the financial performance of PT Mitra Investindo, Tbk. This type of quantitative descriptive research uses secondary data. Data collection techniques are documentation and literature study. Research population for 22 years from the start of listing on the Indonesia Stock Exchange 1997-2019. Then a sample of 10 years from 2010-2019 with purposive sampling technique. The data analysis technique used statistical analysis with a one-sample t-test. The results showed that the Return On Investment (ROI) to assess the financial performance of PT Mitra Investindo, Tbk was in a bad condition because it was less than 30% of the expected.
What is being Illustrated? Case Study of a “Revised” St. Agnes Vita in the Earliest German Translation of the Legenda Aurea (1362)
Authors: Winston-Allen (Emerita) Anne 
Published: July 2021

Abstract
Very few copies of Jacobus de Voragine’s Latin “best seller,” the Legenda aurea, were supplied with illustrations. Yet a large number of its vernacular translations were generously illustrated. Accordingly, these “visual narratives” must also be “read” and interpreted. For, as Mieke Bal observed, an illustration “does not replace a text, it is one.” The image of St. Agnes painted in 1362 for the earliest German translation is a surprising example unlike any other depiction of the saint before or after it. Examining what was behind this image casts light on alternative ways in which different medieval audiences understood the text.
Re-reading Noir
Authors: Smith Erin 
Published: July 2021

ABSTRACT
This article considers Judith Fetterley's The Resisting Reader in relation to the author's current research on Cold-War American women's crime fiction. The dominant critical framework about this fiction from the 1940s, 1950s, and 1960s is noir, a masculinist genre about male loners / outsiders that often embraces a cynical or nihilistic worldview. Many of these books objectify women and feature a spider woman or femme fatale, who is punished for her pursuit of self-interest and use of her sexuality to attain power. The lesser-known female crime writers of the period were–in many ways–resisting readers of this tradition. Their re-readings and rewritings often privileged community and connection over isolation and offered more complicated female characters. The author uses the case of Charlotte Armstrong's A Dram of Poison (1956) to make this case.
Tutela penal nicaragüense de la Propiedad Industrial con énfasis en el delito de fraude sobre patente, modelo de utilidad o diseño industrial
Authors: Flores Páiz Jessica Alexandra 
Published: July 2021

El artículo se centró en analizar un mecanismo de tutela, desde la norma jurídico penal sustantiva, con la que cuentan los titulares de bienes inmateriales, particularmente, los titulares de patentes de invención, modelos de utilidad y de diseños industriales, como medida coercitiva de mayor rigurosidad para perseguir y castigar a los infractores de sus derechos exclusivos con penas que incluye la privación de libertad, para ello se utilizó en la elaboración de este trabajo investigativo el método teórico-documental a través de instrumentos como la exploración y análisis documental de una serie de fuentes primarias y secundarias del conocimiento, mediante lo cual se evidenció por un lado que los delitos contra la Propiedad Industrial presentan características similares que son perfectamente deducibles del propio precepto normativo y por otro lado, se determinó la protección de la Propiedad Industrial desde la norma jurídico penal sustantiva, como una herramienta a conocer y aplicar por los titulares de Derechos de Propiedad Industrial en la resolución de sus controversias en esta materia.
Établissements bilingues et gouvernance francophone : espoirs et déroute du projet universitaire des Franco-Ontariens (1945-2008)
Authors: Dupuis Serge 
Published: July 2021

L’article présente les débuts du projet d’université défendu par les porte-parole franco-ontariens depuis les années 1960. D’abord, l’auteur procède à un rappel des grands moments qui ont jalonné le développement de l’enseignement supérieur en français en Ontario. Ensuite, il montre comment les gouvernements, les organismes francophones et les universités bilingues se sont engagés envers le développement de l’enseignement supérieur en français. Le texte aborde les thèmes de la francisation des universités bilingues, l’élargissement de l’accès aux programmes en français, l’autonomie administrative des francophones et le réseautage des programmes en français dans une nouvelle structure. Au tournant du 21e siècle, le projet de création d’une université par et pour les francophones est apparu comme la réponse la plus cohérente à plus de 40 ans d’expérimentation de solutions plus ou moins satisfaisantes, et ce, malgré l’augmentation de l’offre de programmes en français dans les établissements bilingues. Enfin, l’article permet de dresser un bilan de la situation et d’esquisser des pistes de réflexion pour l’avenir de l’enseignement supérieur en français en Ontario.
Childhood maltreatment and suicidal ideation in Chinese children and adolescents: the mediation of resilience
Authors: Chen Xue , Jiang Linling , Liu Yi , Ran Hailiang , Yang Runxu , Xu Xiufeng , Lu Jin , Xiao Yuanyuan 
Published: July 2021

BackgroundChildhood maltreatment could increase the risk of suicidal ideation (SI) in adolescents. However, the mediation of resilience in this association remains unclear.MethodsA population-based cross-sectional study has been done among 3,146 Chinese adolescents. We collected relevant information from the study participants by using self-administered questionnaire. Chinese version of the Childhood Trauma Questionnaire (CTQ), the Resilience Scale for Chinese Adolescents (RSCA), and the Beck Scale for Suicide Ideation (BSSI) were used to measure childhood maltreatment, resilience, and SI, respectively. Univariate and multivariate binary Logistic regression models were employed to estimate crude and adjusted associations between childhood maltreatment, resilience, and SI. Path analysis has subsequently been performed to measure the mediation of resilience in this association.ResultsMultivariate Logistic regression models revealed that compared to non-abused counterparts, adolescents who had ever experienced any type of childhood maltreatment was 1.74 times likely to report SI. Among the specific types of childhood maltreatment, emotional abuse showed the strongest association with SI (adjusted OR = 3.01, 95% CI [2.37–3.82]). Path model suggested that over one-third (39.8%) of the total association between childhood maltreatment and SI was mediated via resilience. Emotion regulation and interpersonal assistance were the most prominent mediators among all dimensions of resilience.ConclusionsResilience played as a significant mediator in the association between childhood maltreatment and SI. Resilience-oriented intervention measures could be considered for suicidal risk prevention among abused Chinese adolescents.
Assessment of Gender Differences in Depression- A Cross-Sectional study
Authors: Agravat Tushar 
Published: July 2021

Background and Aim: Major depression in both women and men is a debilitating disorder that disrupts relationship and daily lives and affects nearly 10% of general populations. The aims and objectives of this study were to determine the gender differences in major depression with respect to following: Demographic characteristics, Clinical manifestations, Stressful life events, Risk factors.
Materials and Methods: Total of 100 patients was included in the study. All the included patients meet the criteria for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) diagnosis of major depression. The included patients were interviewed at the department of Psychiatry, B. J. Medical College & civil hospital Ahmedabad. Based on the Life Events Scale by Holmes and Rahe (1967), its Indian adaptation PSLE (Presumptive stressful life events scale) was done by Gurmeet Singh (1983). The statistical analysis was done by using SPSS IX version.
Results: Their ages range from 18 to 70 years. Most of the patients were married, were from urban background, and nuclear family. On Hamilton Depression rating scale when the statistical analysis was done, there was no significant difference between males and females. Men had higher mean life events score than women but this was not statistically significant. In female, there was significant positive correlation between number of life events in one year and severity of depression as well as impact score during one year prior to onset of depression and Hamilton rating scores.
Conclusion: Male and female major depression patients did not differ as regards demographic characteristics, except that most women were homemakers and men were employed. Number of stressful life events experienced during 1 year prior to onset of MDD was similar. Early insomnia, middle insomnia and somatic symptoms general were more severely present in female patients.
The resource constrained time/cost tradeoff project scheduling problem with discounted cash flows
Authors: Icmeli Oya , Erenguc S.Selcuk 
Published: July 2002

AbstractMany of the recent studies on Project Scheduling focus on maximizing the Net Present Value (NPV) of cash flows that occur during the implementation of a project in the presence of precedence and resource constraints. The literature contains several integer programming formulations, heuristic procedures and their implementations. In most of these formulations, activity durations are assumed to be fixed. In this paper, we study a practical extension of the problem where the activity durations can be reduced from their normal durations by allocating more resources. Costs associated with such reductions are referred to as crashing costs. The problem under consideration involves determining the timing and duration of activities such that the NPV of all cash flows is maximized in the presence of precedence and resource constraints. We suggest a heuristic procedure for obtaining “good” feasible solutions. We compare the performance of three priority rules embedded in the proposed procedure. Two of these priority rules have been shown to be the most effective in the literature, the third is a new rule developed in this paper. Extensive computational experiments with the heuristic procedure on a total of 380 test problems are reported. The heuristic solutions are compared to benchmark solutions obtained from the best of 50‐randomly generated solutions for each test problem. In addition, upper bounds on the optimal values are obtained by performing Subgradient optimization on a Lagrangian Relaxation of the problem. These upper bounds are used to assess the quality of the heuristic solutions. In general, none of the priority rules produced consistently better results for all the test problems. However, all three priority rules provide “good” quality solutions with modest computational effort. The Lagrangian approach is found to provide tight bounds on the optimal values.
Ganglioside GM1 and GM3 in early human brain development: An immunocytochemical study
Authors: Stojiljković M. , Blagojević T. , Vukosavić S. , Zvezdina N.D. , Peković S. , Nikezić G. , Rakić L. 
Published: July 2002

AbstractThe distribution of GM1 and GM3 gangliosides in human brain development between gestational week (g.w.) 6 and 15 was demonstrated by an immunocytochemical approach using polyclonal anti‐GM1 and anti‐GM3 antibodies. The first appearance of GM1‐ and GM3‐positive cells was recorded as early as in g.w. 6. Both antibodies labeled the cells in the ventricular zone of the telencephalic wall, with radially oriented fibers toward the pial surface, which represent radial glia cells with glia fibers. The intensive GM3 immunoreactivity was also exhibited in proliferating cells in the ventricular zone between g.w. 6 and 12. During the period from g.w. 12 to 15, characterized by a rapid multiplication of neurons and glia cells, an increased number of GM1‐ and GM3‐positive cells was observed. Prominent GM1 ganglioside staining was observed at the surface of the cell bodies in the ventricular zone. Besides surface labeling in migrating cells, GM1 immunoreactivity was identified inside the soma in the regions of cortical plate and subplate. GM1 immunoreactivity was more pronounced on the membrane of neuronal cells migrating along radial glia fibers, especially at the contact site between neuronal and glial cells. The GM3 ganglioside was localized mostly inside the soma, showing a granular immunoreactivity pattern.Our observations confirm the presence of GM1 and GM3 gangliosides in neuronal and glial cells in early human brain development. The involvement, especially of GM1 ganglioside in glia‐neuronal contacts during migration of neuroblasts to their final destination, as well as the presence of GM3 ganglioside in proliferative cells in the ventricular zone of the telencephalic wall was also recorded.
Illegal abortion: consequences for women's health and the health care system
Authors: Faúndes A. , Hardy E. 
Published: July 2002

AbstractIllegal abortion is responsible for up to half of maternal deaths and consumes a large proportion of health resources in many developing countries, particularly in Africa and Latin America. The legal situation of abortion in a country does not influence the abortion rate, but illegality is associated with a much greater risk of complications and death. To make abortion legal is not enough. Access to safe abortion strongly depends on the capacity and willingness of physicians and the health system to provide safe services, which sometimes are made available in spite of restrictive laws. The abortion rate will drop and the safety of the procedure will improve, parallel to the position women occupy in a given society, and to the level of recognition of their sexual and reproductive rights. The medical profession, and FIGO in particular, has a great role to play in implementing initiatives that will reduce the consequences of illegal abortion for women and society.
Prophylactic augmentin in prelabor preterm rupture of the membranes
Authors: Magwali T.L. , Chipato T. , Majoko F. , Rusakaniko S. , Mujaji C. 
Published: July 2002

AbstractObjective: To determine whether the use of prophylactic Augmentin in PPROM prolongs gestation and reduces neonatal and maternal morbidity due to sepsis. Method: Study setting was Harare Maternity Hospital, Zimbabwe. Women with PPROM between 26 and 36 weeks' gestation were randomly allocated either to a group given a course of prophylactic oral Augmentin or another receiving no prophylactic antibiotic treatment. The calculated sample size was 72 women per group. Data were analyzed using the EPI INFO program. Results: A total of 171 women were recruited into the study, 84 in the Augmentin group and 87 in the No Treatment group. The group receiving prophylactic Augmentin had a significantly longer latency period between rupture of membranes and delivery. There was a trend towards increased neonatal and maternal morbidity due to sepsis in the No Treatment group although no statistical significance was reached. Conclusion: The use of prophylactic Augmentin in PPROM significantly prolongs gestation. It appears to decrease neonatal and maternal morbidity due to sepsis.
The effects of partial and total interosseous membrane transection on load sharing in the cadaver forearm
Authors: Shepard Michael F. , Markolf Keith L. , Dunbar Arati M. 
Published: July 2002

AbstractThis study was performed to examine the effects of partial and total transection of the interosseous membrane (IOM) on load transfer in the forearm. Twenty fresh frozen forearms were instrumented with custom designed load cells placed in the proximal radius and distal ulna. Simultaneous measurements of load cell forces, radial head displacement relative to the capitellum, and local tension within the central band of the IOM were made as the wrist was loaded to 134 N with the forearm at 90° of elbow flexion and in neutral pronation supination. For valgus elbow alignment (radial head contacting the capitellum), mean force carried by the distal ulna was 7.1% of the applied wrist force and mean force transferred from radius to ulna through the IOM was 4.4%. For varus elbow alignment (mean 2.0 mm gap between the radial head and capitellum), mean distal ulna force was 28% and mean IOM force was 51%. Section of the proximal and distal one‐thirds of the IOM had no significant effect upon mean distal ulnar force or mean IOM force. Total IOM section significantly increased mean distal ulnar force for varus elbow alignment in all wrist positions tested. The mean level of applied wrist force necessary to close the varus gap (89 N) decreased significantly after both partial IOM section (71 N) and total IOM section (25 N). The IOM became loaded only when the radius displaced proximally relative to the ulna, closing the gap between the radius and capitellum. As the radius displaced proximally, the wrist becomes increasingly ulnar positive, which in turn leads to direct loading of the distal ulna. This shift of force to the distal ulna could present clinically as ulnar sided wrist pain or as ulnar impaction after IOM injury. © 2001 Orthopaedic Research Society. Punlished by Elsevier Science Ltd. All rights reserved.