bluuebunny/crossref_metadata_2025_split huggingface dataset:
God So Loved the World
Authors: Amos Clare 
Published: February 2021

AbstractThe account of the near sacrifice of Isaac in Genesis 22, often referred to as the Aqedah, has been profoundly influential, both directly and indirectly, in Jewish, Christian, and Muslim theological reflection. This article seeks to explore some Christian insights into the use of the motif of the sacrifice of Isaac, suggesting that its use is fundamental to understanding the theme of Christ’s love in the Gospel of John, in particular the link between love, sacrifice, and unity. With a brief exploration of two artworks by Marc Chagall, The Sacrifice of Isaac and the White Crucifixion, it will also raise questions as to what this might mean for the relationship between Christianity and Judaism.
Love Your Neighbour as Yourself
Authors: Hadsell Heidi 
Published: February 2021

AbstractThis paper examines the many ways interreligious dialogue and interreligious relationship‐building interact with and serve how we live out – with others – the moral core of the Christian faith, which is the love of God and neighbour. I take as an example the contemporary Poor People’s Campaign in the United States. The campaign originated with the Rev. Dr Martin Luther King Jr, the Rev. Ralph Abernathy, and others involved in the civil rights movements of the early 1960s. While the Poor People’s Campaign was initiated by and is led by Christians, it is intentionally inclusive of people of many different faiths and those with no particular faith, all of whom share the commitment to love and to serve the poor.
Contributions of Religious Actors to Peace and Security
Authors: Petersen Henrik Sonne , Wandera Joseph 
Published: February 2021

AbstractThe past decade has seen a shift of rhetoric, where religious actors are presented not just as aberrations in the secular and democratic order, but also as significant players in the development of peaceful and diversified societies. However, experiences of extremist religious groups raise questions about the legitimacy of involving religious actors in these kinds of processes, in particular in relation to security, which according to a classical perspective is a matter of national and international security agencies. This paper analyzes the challenges relating to the inclusion of religious actors in security situations in East Africa, particularly those involving confrontations between religious actors, in which the concept of the “religious other” has a specific reference. The main finding is that religious actors have a contribution to make in relation to security and conflict involving religion and faith, given that security is understood in a broader sense than the classical.
Climate warming extends growing season but not reproductive phase of terrestrial plants
Authors: Liu Huiying , Lu Chunyan , Wang Songdan , Ren Fei , Wang Hao 
Published: February 2021

AbstractAimUnderstanding how plant phenophases respond to climate warming is key to prediction of future ecosystem dynamics. Although warming has lengthened the growing season of plants in most terrestrial ecosystems, little is known about the contribution of different phenophases to this extension.LocationGlobal terrestrial ecosystems.Time periodData collected from 1979 to 2020.Major taxa studiedTerrestrial plants.MethodsHere, we conducted a global meta‐analysis, compiling 772 pairs of observational data from 42 warming manipulative experiments to investigate the temperature sensitivity (expressed as days per degree Celsius) of the durations of different phenophases across major natural terrestrial ecosystems.ResultsWe found that the durations of flower bud, flowering and fruiting and the total reproductive phase did not exhibit any significant change in response to experimental warming across all terrestrial plants, although large variations in temperature sensitivity of the reproductive phenology existed. The temperature sensitivity of reproductive phases was influenced by the taxa of plants. Specifically, the flower bud duration of C4 plants had a higher temperature sensitivity than that of C3 plants, and the flowering duration in woody plants exhibited a marginally higher temperature sensitivity than in herbaceous plants. In contrast to the small responses of the reproductive phases, the growing season lengthened under experimental warming. The temperature sensitivity of the growing season length was strongly affected by the magnitude of warming, showing a slower lengthening of the growing season with larger increases in temperatures.Main conclusionsThese results suggest that, under future warmer climates, terrestrial plants will allocate more time to growth than to reproduction; however, the warming‐induced extension of the vegetative phase might slow down over time.
Evaluating the effectiveness of let’s talk period’s high school educational outreach program: A pilot study
Authors: Hossenbaccus Lubnaa , Thibeault Lisa , Grabell Julie , Braund Heather , Hopman Wilma , James Paula 
Published: February 2021

AbstractIntroductionMenorrhagia impacts ~40% of adolescent females, with about half having an underlying bleeding disorder, most commonly von Willebrand Disease (VWD). VWD affects ~1 in 1000 individuals, though many are unaware of their condition. Let's Talk Period (LTP) is an online knowledge translation platform aimed at increasing awareness of bleeding disorders symptoms, with a validated self‐administered bleeding assessment tool (Self‐BAT).AimTo evaluate the effectiveness of the LTP high school outreach program in Grade 9 girls’ health classes quantitatively, using baseline, post‐presentation, and follow‐up quiz scores, and qualitatively, with student and teacher feedback forms.MethodsThe 75‐minute in‐class presentations, developed in alignment with the 2015 Ontario Curriculum for Grade 9 Health and Physical Activity, were led by a haemophilia nurse, clinical research assistant, and undergraduate student from the LTP team. Students completed baseline, post‐presentation, and 4–6‐week follow‐up Kahoot quizzes featuring the same nine questions to evaluate change in knowledge levels and retention. Both student and teacher feedback were collected.ResultsThere was a significant increase (p < 0.001) from baseline to post‐presentation scores, with a significant gain in knowledge, for all questions (p < 0.01). Students found content related to the basics and management of menstruation to be most interesting. Many had constructive feedback on how the presentation method could be improved. On average, the presentations were rated an 8.6 of 10 by students and 8.75 of 10 by teachers.ConclusionThe LTP high school outreach program effectively increases student knowledge of menorrhagia and bleeding disorders. It was well‐received by students and staff alike.
Not as simple as it seems: The ILO and the personal scope of international labour standards
Authors: DE STEFANO Valerio 
Published: February 2021

AbstractThis article examines the personal scope of the international labour standards of the ILO. It argues that they do not set out a universal definition of the terms “employee” or “employment relationship”. Instead, when the standards use such terms, their scope should be determined on a case‐by‐case basis and by referring to the travaux préparatoires and the opinions of the ILO supervisory bodies. This article closely analyses both the application of ILO fundamental Conventions by the supervisory bodies and the most recent ILO debates concerning the personal scope of international labour standards.
Current issues in the prevalence, diagnosis and management of hepatocellular carcinoma in Australia
Authors: Lubel John S. , Roberts Stuart K. , Howell Jessica , Ward James , Shackel Nichols A. 
Published: February 2021

AbstractHepatocellular carcinoma (HCC) is the commonest primary liver cancer encountered in the community and a leading cause of cancer morbidity and mortality. In Australia, there are several current important issues that need to be addressed in HCC management. There is a dramatically rising incidence of HCC in Australia with comparatively poorer outcomes in remote regions and in socioeconomic disadvantaged groups. Aboriginal people have a greater incidence of HCC on a background of increased liver disease prevalence and face several barriers to delivery of better healthcare outcomes compared to other Australians. The previously adopted use of imaging alone to diagnose HCC is now being challenged with biopsy likely to become increasingly necessary with the increased uptake of personalised medicine management. Managing HCC is complex involving many disciplines with the multidisciplinary team approach being the current accepted standard of care for patients. New immunotherapy combinations promise to offer patients with advanced HCC promising novel management options. However, the Australian inequities in prevalence, diagnosis and service provision, especially in Aboriginal people, need to be redressed concurrently with the adoption of new HCC management options.
Incidence and predictors of idiopathic pulmonary fibrosis complicating Type 2 diabetes: the Fremantle Diabetes Study Phase I
Authors: Navaratnam Vidya , Davis Timothy M. E. , Hubbard Richard , Davis Wendy A. 
Published: February 2021

AbstractDuring 106 865 person‐years of follow up, 17 (1.3%) Fremantle Diabetes Study Phase I participants with Type 2 diabetes and 57 (1.1%) matched individuals without diabetes developed idiopathic pulmonary fibrosis (IPF), an incidence rate ratio (95% confidence interval) of 1.40 (0.76–2.44) (P = 0.22). In the diabetes cohort, age at diabetes diagnosis and total serum cholesterol (inversely) predicted incident IPF in competing risk multivariable models. The incidence of IPF was low in community‐based cohorts, regardless of Type 2 diabetes status.
Effect of the COVID‐19 induced phase of massive telehealth uptake on end‐user satisfaction
Authors: Bate Nicole J. , Xu Simon C. , Pacilli Maurizio , Roberts Lynden J. , Kimber Chris , Nataraja Ramesh M. 
Published: February 2021

AbstractBackgroundCOVID‐19 has resulted in a massive increase in telehealth utilisation.AimsTo determine the user and clinician satisfaction during this period and compare to a pre‐COVID‐19 cohort.MethodsA prospectively collected voluntary questionnaire following the telehealth appointment at a tertiary‐level hospital with all adult and paediatric‐based specialities was conducted over two time periods: COVID‐19 (16 March 2020 to 15 April 2020) and pre‐COVID‐19 (1 January 2019 to 31 December 2019). There were four groups of participants: patients; parents; adult‐based clinicians; and paediatric‐based clinicians. The outcomes assessed included perceived standard of care, willingness for repeat telehealth consultations, and patient and parental perceptions of safety.ResultsFive thousand and thirty‐three telehealth consultations occurred in the COVID‐19 period with 1757 questionnaires completed, compared to 1917 consultations with 271 questionnaires completed in the pre‐COVID‐19 period. Clinicians were more likely to have previously used telehealth in both time periods than end‐users. In COVID‐19, 1240 actual onsite hospital outpatients' visits were prevented. All groups reported a good overall impression of the telehealth quality; patients/parents scored higher compared to clinicians: 3.6/4 versus 3.3/4, P = 0.02 (pre‐COVID‐19) and 3.3/4 versus 2.8/4, P = 0.001 (COVID‐19). The majority of patients and parents (90%, 1379/1528) felt safer by having a telehealth appointment compared to a face‐to‐face appointment in the COVID‐19 pandemic. All participant groups reported an overall good standard of care, good levels of engagement and were strongly willing to use telehealth again in both of the study time periods. Patients and parents consistently rated higher than clinicians.ConclusionsDuring a rapid increase in its utilisation and scope due to the COVID‐19 pandemic, telehealth was generally well accepted by patients, parents and clinicians, which was consistent with pre‐COVID‐19 experiences.
Si fertigation attenuates water stress in forages by modifying carbon stoichiometry, favouring physiological aspects
Authors: Rocha Juan Ricardo , de Mello Prado Renato , Teixeira Gelza Carliane Marques , de Oliveira Filho Antonio Santana Batista 
Published: February 2021

AbstractClimate change has aggravated the occurrence of drought periods, affecting pasturelands in different regions of the world. Silicon attenuates water deficiency in several species, but there is a lack of research to verify whether Si can modify C stoichiometry and its effects in mitigating water deficit in forage plants. To this end, this research was carried out with the aim of evaluating whether Si supply via fertigation causes an increase in its absorption, stoichiometric modification of C and improvement in physiological variables and in the growth of Brachiaria cultivated under two soil water regimes (70% and 40% of water holding capacity in the soil). Two experiments were carried out with the cultivars BRS RB331 Ipyporã and Mavuno grown in pots filled with Quartzipsamments. In the experiments, the same treatments arranged in a 2 × 2 factorial scheme were applied, with Si application via fertigation applied to the soil and control (Si omission) combined with two soil water regimes (70% and 40% of the water retention capacity in the soil, adequate and deficient water contents, respectively). The two forages that received silicon via fertigation specially cultivated under water deficit had a greater accumulation of Si in the shoot, decreased C content and C:Si ratio and increased C use efficiency, and decreased rate of electrolyte leakage with increased relative water content, leaf water potential, chlorophyll b content, quantum efficiency of photosystem II and, consequently, increased growth and dry matter production. The present research shows that the use of Si via fertigation promotes a new strategy to mitigate water deficit in forages, based on the improvement of the physiological aspects of the plant resulting from the modification of carbon stoichiometry, thereby increasing C use efficiency.
Life in the “dead heart” of Australia: The geohistory of the Australian deserts and its impact on genetic diversity of arid zone lizards
Authors: Pepper Mitzy , Keogh J Scott 
Published: February 2021

AbstractAimThe Australian deserts are home to a remarkable diversity of taxa that might appear to have evolved in the absence of topographic and physical barriers to dispersal. In fact this is a biogeographical illusion, as the dunefields of the modern arid zone obscure the fossil landscapes of the wet desert that existed for much of the Cenozoic. As the geohistory of Australia's arid zone is not widely understood by biologists, we review its geological development and contemporary landscapes in an accessible way, and describe eight biogeographical hypotheses centred on how geomorphology, evolutionary history and contemporary ecological factors interact to shape diversification patterns in the desert lowlands.LocationAustralia.TaxonLizards.MethodsWe review the arid zone landscapes before and after the development of the vast dunefields. As lizards represent a significant component of genetic studies that sample widely across the arid biome, we focus on this taxonomic group to establish emerging patterns.ResultsRecent geological work suggests that the dunefields never formed extensive mobile landscapes such as in the Sahara, but rather were a mosaic of vegetated and stable dune surfaces with scattered bare, mobile patches. Large fluvial systems in the eastern arid zone during the Pleistocene also are at odds with the general perception of an arid landscape during this time. Incorporating this geohistorical insight, understanding where landscape heterogeneity is greatest within the arid zone, and where relative homogeneity might facilitate connectivity and gene flow, are at the heart of our biogeographic hypotheses.Main conclusionsPatterns are emerging that reflect the underlying influence of geomorphological processes on the genetic structure of Australian desert taxa. Quantifying finer‐scale edaphic complexity across the arid zone, widespread genetic sampling from disparate taxonomic groups, and a more detailed understanding of species ecology and life history will greatly improve our understanding of the ecological and historical drivers of diversity gradients in the Australian deserts.
Construction of a robust prognostic model for adult adrenocortical carcinoma: Results from bioinformatics and real‐world data
Authors: Tian Xi , Xu Wen‐Hao , Anwaier Aihetaimujiang , Wang Hong‐Kai , Wan Fang‐Ning , Cao Da‐Long , Luo Wen‐Jie , Shi Guo‐Hai , Qu Yuan‐Yuan , Zhang Hai‐Liang , Ye Ding‐Wei 
Published: February 2021

AbstractThis study aims to construct a robust prognostic model for adult adrenocortical carcinoma (ACC) by large‐scale multiomics analysis and real‐world data. The RPPA data, gene expression profiles and clinical information of adult ACC patients were obtained from The Cancer Proteome Atlas (TCPA), Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). Integrated prognosis‐related proteins (IPRPs) model was constructed. Immunohistochemistry was used to validate the prognostic value of the IPRPs model in Fudan University Shanghai Cancer Center (FUSCC) cohort. 76 ACC cases from TCGA and 22 ACC cases from GSE10927 in NCBI’s GEO database with full data for clinical information and gene expression were utilized to validate the effectiveness of the IPRPs model. Higher FASN (P = .039), FIBRONECTIN (P < .001), TFRC (P < .001), TSC1 (P < .001) expression indicated significantly worse overall survival for adult ACC patients. Risk assessment suggested significantly a strong predictive capacity of IPRPs model for poor overall survival (P < .05). IPRPs model showed a little stronger ability for predicting prognosis than Ki‐67 protein in FUSCC cohort (P = .003, HR = 3.947; P = .005, HR = 3.787). In external validation of IPRPs model using gene expression data, IPRPs model showed strong ability for predicting prognosis in TCGA cohort (P = .005, HR = 3.061) and it exhibited best ability for predicting prognosis in GSE10927 cohort (P = .0898, HR = 2.318). This research constructed IPRPs model for predicting adult ACC patients’ prognosis using proteomic data, gene expression data and real‐world data and this prognostic model showed stronger predictive value than other biomarkers (Ki‐67, Beta‐catenin, etc) in multi‐cohorts.
Elevated angiotensin II induces platelet apoptosis through promoting oxidative stress in an AT1R‐dependent manner during sepsis
Authors: Xu Dun‐Feng , Liu Yu‐Jian , Mao Yan‐Fei , Wang Yan , Xu Chu‐Fan , Zhu Xiao‐Yan , Jiang Lai 
Published: February 2021

AbstractThrombocytopenia is independently related with increased mortality in severe septic patients. Renin‐angiotensin system (RAS) is elevated in septic subjects; accumulating studies show that angiotensin II (Ang II) stimulate the intrinsic apoptosis pathway by promoting reactive oxygen species (ROS) production. However, the mechanisms underlying the relationship of platelet apoptosis and RAS system in sepsis have not been fully elucidated. The present study aimed to elucidate whether the RAS was involved in the pathogenesis of sepsis‐associated thrombocytopenia and explore the underlying mechanisms. We found that elevated plasma Ang II was associated with decreased platelet count in both patients with sepsis and experimental animals exposed to lipopolysaccharide (LPS). Besides, Ang II treatment induced platelet apoptosis in a concentration‐dependent manner in primary isolated platelets, which was blocked by angiotensin II type 1 receptor (AT1R) antagonist losartan, but not by angiotensin II type 2 receptor (AT2R) antagonist PD123319. Moreover, inhibiting AT1R by losartan attenuated LPS‐induced platelet apoptosis and alleviated sepsis‐associated thrombocytopenia. Furthermore, Ang II treatment induced oxidative stress level in a concentration‐dependent manner in primary isolated platelets, which was partially reversed by the AT1R antagonist losartan. The present study demonstrated that elevated Ang II directly stimulated platelet apoptosis through promoting oxidative stress in an AT1R‐dependent manner in sepsis‐associated thrombocytopenia. The results would helpful for understanding the role of RAS system in sepsis‐associated thrombocytopenia.
Tumour angiogenesis normalized by myo‐inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response
Authors: El Hafny‐Rahbi Bouchra , Brodaczewska Klaudia , Collet Guillaume , Majewska Aleksandra , Klimkiewicz Krzysztof , Delalande Anthony , Grillon Catherine , Kieda Claudine 
Published: February 2021

AbstractPathologic angiogenesis directly responds to tumour hypoxia and controls the molecular/cellular composition of the tumour microenvironment, increasing both immune tolerance and stromal cooperation with tumour growth. Myo‐inositol‐trispyrophosphate (ITPP) provides a means to achieve stable normalization of angiogenesis. ITPP increases intratumour oxygen tension (pO2) and stabilizes vessel normalization through activation of endothelial Phosphatase‐and‐Tensin‐homologue (PTEN). Here, we show that the tumour reduction due to the ITPP‐induced modification of the tumour microenvironment by elevating pO2 affects the phenotype and properties of the immune infiltrate. Our main observations are as follows: a relative change in the M1 and M2 macrophage‐type proportions, increased proportions of NK and CD8+T cells, and a reduction in Tregs and Th2 cells. We also found, in vivo and in vitro, that the impaired access of PD1+NK cells to tumour cells is due to their adhesion to PD‐L1+/PD‐L2+ endothelial cells in hypoxia. ITPP treatment strongly reduced PD‐L1/PD‐L2 expression on CD45+/CD31+ cells, and PD1+ cells were more numerous in the tumour mass. CTLA‐4+ cell numbers were stable, but level of expression decreased. Similarly, CD47+ cells and expression were reduced. Consequently, angiogenesis normalization induced by ITPP is the mean to revert immunosuppression into an antitumor immune response. This brings a key adjuvant effect to improve the efficacy of chemo/radio/immunotherapeutic strategies for cancer treatment.
Sexual dimorphism in the otolith shape of shi drum, Umbrina cirrosa (L.), in the eastern Mediterranean Sea: Fish size–otolith size relationships
Authors: Başusta Nuri , Dürrani Ömerhan 
Published: February 2021

AbstractLittle is known about possible differences in sagitta otolith size and shape between sexes of the shi drum, Umbrina cirrosa, and relationships between their body and otolith size. Thus, this study aimed to fill this knowledge gap via examination of 414 sagittal otoliths from 108 male (total length 13.8–26.8 cm) and 99 female (13.5–26.7 cm) U. cirrosa caught between May 2017 and April 2018 in gillnets set at a depth of ~15 m in Mersin Bay, Eastern Mediterranean Sea. No statistical differences were observed between the shape indices of the left‐sided and right‐sided sagitta. However, there were significant differences in the size and shape of otoliths between males and females. The slopes of allometric power functions from otolith width × fish sizes gave significant differences between males and females (ANCOVA, P < 0.05). The relationship for length × weight of otoliths from both males and females showed isometric growth, whereas the relationship of otolith width × otolith weight showed positive allometry. Negative allometric growth was observed for the relationship otolith length × otolith width. In summary, this study revealed the presence of sexual dimorphism in the otolith shape of U. cirrosa, and the data on regression relationships of fish‐otolith sizes can be used to estimate fish size from U. cirrosa otolith sizes.