bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Value of Endotracheal Tube-Aspirate Soluble Triggering Receptor Expressed on Myeloid Cells-1 Concentration for Neonatal Ventilator-Associated Pneumonia
Authors: Zhou Jian , Zhou Jingqian , Hong Yan , Wang Youcheng , Lin Hailong , Huang Leting 
Published: August 2021

Background: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is regarded as a biological marker of infection. We aimed to evaluate the diagnostic value of endotracheal tube (ETT)-sTREM-1 concentration in neonatal ventilator-associated pneumonia (NVAP), to explore the difference of (ETT)-sTREM-1 between preterm and full-term, and to investigate the influence of extrapulmonary infection on (ETT)-sTREM-1 concentration.Methods: In this multicenter, controlled clinical trial of 60 preterm and 33 full-term neonates on mechanical ventilators, we measured concentrations of ETT-aspirate and serum sTREM-1, serum C-reactive protein, and serum procalcitonin, as well as white blood cell count. We initially divided cases into eight groups, based on three categories: preterm of full-term; NVAP or non-NVAP; and extrapulmonary infection present or absent. Groups were compared, and logistic regression analysis and receiver operating characteristic (ROC) analysis was performed to determine diagnostic value.Results: The mean gestational age (± standard deviation) of preterm and full-term neonates was 28.9 ± 2.2 weeks and 39.5 ± 1.7 weeks, respectively, and 32/60 were male. The ETT-aspirate sTREM-1 concentration was higher in NVAP cases than in non-NVAP cases, irrespective of extrapulmonary infection. ROC analysis revealed that ETT-aspirate sTREM-1 concentration had an area under the curve (AUC) of 0.986 and a cutoff value of 228.0 pg/ml (sensitivity, 94.3%; specificity, 96%) in preterm neonates; the same values in full-term neonates were 0.938 and 245.5 pg/ml (sensitivity, 100%; specificity, 93.7%), respectively. The optimal combination of indicators was ETT-aspirate sTREM-1 and serum C-reactive protein concentration. All indicators were present at lower levels on days 8 and 10 of ventilation in neonates who ultimately recovered than in those who did not.Conclusions: ETT-aspirate sTREM-1 and serum C-reactive protein concentrations may be useful for the diagnosis of NVAP.
Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway
Authors: Yang Runan , Li Zijing , Zou Yuting , Yang Jingjian , Li Lin , Xu Xiumei , Schmalzing Günther , Nie Hong , Li Guilin , Liu Shuangmei , Liang Shangdong , Xu Changshui 
Published: August 2021

Neuropathic pain is a complex disease with high incidence. Adenosine triphosphate (ATP) and its activated P2X7 receptor are involved in the signal transmission of neuropathic pain. Gallic acid (3,4,5-trihydroxybenzoic acid) is a traditional Chinese medicine obtained from natural plants that exhibit anti-inflammatory, analgesic, and antitumor effects. However, the underlying mechanism for gallic acid in analgesia remains unknown. This study aims to reveal how gallic acid alleviates neuropathic pain behaviors in a rat model with chronic constriction injury (CCI). Real-time PCR, western blotting, double-label immunofluorescence, molecular docking, and whole-cell patch clamp technology were used to explore the therapeutic action of gallic acid on neuropathic pain. The results showed that after CCI rats were treated with gallic acid for 1 week, the mechanical withdrawal threshold and thermal withdrawal latency were increased, accompanied by inhibition of the upregulated expression of P2X7 and TNF-α at both mRNA and protein levels, and reduced NF-κB and phosphorylated-STAT3 in the dorsal root ganglia. At the same time, gallic acid significantly decreased the coexpression of P2X7 and glial fibrillary acidic protein in the dorsal root ganglia. In addition, gallic acid could suppress ATP-activated current in human embryonic kidney 293 (HEK293) cells transfected with the plasmid expressing P2X7 but had no effect on ATP activation current of P2X7-mutant plasmid (with the point mutation sequence of the key site where gallic acid binds to the P2X7 receptor). Therefore, our work suggests that gallic acid may alleviate neuropathic pain in CCI rats by inhibiting the P2X7 receptor and subsequent activation of the TNF-α/STAT3 signaling pathway.
Localized Pulmonary Vein Scar Promotes Atrial Fibrillation in High Left Atrial Pressure
Authors: Gottlieb Lisa A. , Vaillant Fanny , Abell Emma , Belterman Charly , Loyer Virginie , El Hamrani Dounia , Naulin Jérôme , Constantin Marion , Quesson Bruno , Boukens Bastiaan J. , Coronel Ruben , Dekker Lukas R. C. 
Published: August 2021

BackgroundPulmonary vein (PV) ablation is unsuccessful in atrial fibrillation (AF) patients with high left atrial (LA) pressure. Increased atrial stretch by increased pressure is proarrhythmic for AF, and myocardial scar alters wall deformation. We hypothesized that localized PV scar is proarrhythmic for AF in high LA pressure.MethodsRadiofrequency energy was delivered locally in the right PV of healthy sheep. The sheep recovered for 4 months. Explanted hearts (n = 9 PV scar, n = 9 controls) were perfused with 1:4 blood:Tyrode’s solution in a four-chamber working heart setup. Programmed PV stimulation was performed during low (∼12 mmHg) and high (∼25 mmHg) LA pressure. An AF inducibility index was calculated based on the number of induction attempts and the number of attempts causing AF (run of ≥ 20 premature atrial complexes).ResultsIn high LA pressure, the presence of PV scar increased the AF inducibility index compared with control hearts (0.83 ± 0.20 vs. 0.38 ± 0.40 arb. unit, respectively, p = 0.014). The diastolic stimulation threshold in high LA pressure was higher (108 ± 23 vs. 77 ± 16 mA, respectively, p = 0.006), and its heterogeneity was increased in hearts with PV scar compared with controls. In high LA pressure, the refractory period was shorter in PV scar than in control hearts (178 ± 39 vs. 235 ± 48 ms, p = 0.011).ConclusionLocalized PV scar only in combination with increased LA pressure facilitated the inducibility of AF. This was associated with changes in tissue excitability remote from the PV scar. Localized PV ablation is potentially proarrhythmic in patients with increased LA pressure.
The Effect of Child Quantity and Education on Parents' Well-Being in Vietnam
Authors: Vu Linh Hoang , Phung Tung Duc 
Published: August 2021

Background: Vietnam currently has a rapidly aging population, while formal social protection has only covered a small fraction of older people. Therefore, many older people with insufficient income or poor health must rely on their children's support.Method: This study uses the Vietnam National Aging Survey 2011 to determine whether the quality of children's education/employment and the number of children in a family impact older people's life satisfaction and health.Results: We find that the number of children has no effect on parents' life satisfaction but is adversely related to parents' health across a range of physical and mental health measures. In contrast, children's education has beneficial impacts on the well-being of elderly parents. Parents with better-educated children are more satisfied with their lives and report better health and fewer illness issues. Among other factors, income and wealth are strong and consistent predictors of older people's life satisfaction and self-perceived physical and mental health.Conclusion: To the best of our knowledge, this is the first study to explore the relationship between quantity and quality of children and the well-being of elderly parents. Our results show that the number of children has an adverse effect on older people's self-reported health and life satisfaction in Vietnam. Meanwhile, parental health and life satisfaction are significantly related to children's education. The findings of this study provide several practical implications. Most importantly, investment in education for children will have long-lasting impacts on the health and well-being of elderly adults. In addition, our paper indicates that the government program for reducing fertility has contributed to the longer-term health of people.
Cost-Effectiveness of a School-and Family-Based Childhood Obesity Prevention Programme in China: The “CHIRPY DRAGON” Cluster-Randomised Controlled Trial
Authors: Zanganeh Mandana , Adab Peymane , Li Bai , Pallan Miranda , Liu Wei Jia , Hemming Karla , Lin Rong , Liu Wei , Martin James , Cheng Kar Keung , Frew Emma 
Published: August 2021

Objectives: Rapid socioeconomic and nutrition transitions in Chinese populations have contributed to the growth in childhood obesity. This study presents a cost-effectiveness analysis of a school- and family-based childhood obesity prevention programme in China.Methods: A trial-based economic evaluation assessed cost-effectiveness at 12 months. Forty schools with 1,641 children were randomised to either receive the multi-component (diet and physical activity) intervention or to continue with usual activities. Both public sector and societal perspectives were adopted. Costs and benefits in the form of quality-adjusted life years (QALYs) were compared and uncertainty was assessed using established UK and US thresholds.Results: The intervention cost was 35.53 Yuan (£7.04/US$10.01) per child from a public sector perspective and 536.95 Yuan (£106/US$151) from a societal perspective. The incremental cost-effectiveness ratio (ICER) was 272.7 Yuan (£54/US$77)/BMI z-score change. The ICER was 8,888 Yuan (£1,760/US$2,502) and 73,831 Yuan (£14,620/US$20,796) per QALY from a public sector and societal perspective, respectively and was cost-effective using UK (£20,000) and US (US$50,000) per QALY thresholds.Conclusion: A multi-component school-based prevention programme is a cost-effective means of preventing childhood obesity in China.
Hemoglobinuria in the Early Poststem-Cell–Transplant Period: Risk Factors and Association with Outcomes
Authors: Kompotiatis Panagiotis , Manohar Sandhya , Alkhateeb Hassan B. , Hogan William J. , Nath Karl A. , Leung Nelson 
Published: August 2021

Key Points

Post-HSCT hemoglobinuria was associated with graft type (BMT+Cord).Post-HSCT hemoglobinuria was associated with early (48–72 hours) post-HSCT AKI.Graft type (BMT+Cord) was associated with AKI among patients with hemoglobinuria.

Background
Information on risk factors of hemoglobinuria after hematopoietic stem-cell transplant (HSCT) and its association with AKI, mortality, and engraftment is limited.

Methods
We conducted a retrospective cohort study on all consecutive adults that underwent HSCT from January 6, 1999, to November 6, 2017. The study included 6039 patients that underwent bone marrow transplantation (BMT), umbilical cord blood, and peripheral blood stem-cell transplantation (PBSCT).

Results
Early post-HSCT, AKI occurred in 393 (7%) patients, and 52 (0.9%) patients had post-HSCT hemoglobinuria. Post-HSCT hemoglobinuria was associated with graft type (BMT+Cord), underlying disease (lymphoma, acute leukemia), and fludarabine-based conditioning regimen. Post-HSCT hemoglobinuria was associated with early (48–72 hours) post-HSCT AKI. Graft type (BMT+Cord) was associated with AKI among patients with hemoglobinuria. AKI in patients with hemoglobinuria was associated with delayed platelet engraftment and delayed WBC engraftment but not 100-day mortality.

Conclusion
Close monitoring is recommended in this patient group to facilitate a good engraftment outcome.
ÜÇ KUŞAKTA KORONAVİRÜS VE SOMESFOBİ
Authors: GÜNLÜ Aykut 
Published: August 2021

Mevcut çalışmanın temel amacı koronavirüsün aile bireyleri tarafından nasıl algılandığının belirlenmesidir. Çalışmanın bir diğer amacı ise çocukların koronavirrüs sürecinde virüs ile ilgili düşünce ve algılarının belirlenmesidir. Çalışmadaki veriler nitel veri toplama araçlarından görüşme tekniği ile toplanmıştır. Çalışmanın yöntemi, nitel araştırma türlerinden gömülü araştırma desenine dayalı bir çalışmadır. Mevcut araştırmanın örneklemi amaçlı örnekleme yöntemlerinden ölçüt örnekleme yöntemi ile belirlenmiştir. Çalışma grubuna 16 aile (toplam 48 kişi) katılmıştır. Aile bireylerinden çocukların koronavirüs ile ilgili algılarının; anne-babayla daha çok zaman geçirme, kendini dinleyebilme, büyükanne/büyükbabaya sarılamama, oyun oynayamama, parka çıkamama, yüz yüze eğitimin uzaktan eğitime dönüşmesi şeklinde olduğu görülmektedir. Annelerin nasıl algıladığına bakıldığında; çocuklarla daha çok birlikte zaman geçirebilme, kitap okuyabilme, kendine zaman ayıra- bilme, uzaktan eğitimin takip edilmek zorunda olunması, sosyal yaşamın değişmesi, endişenin artması, belirsizliğin devam etmesi, büyüklerle sosyal mesafenin korunmaya çalışılması kategorisinde olduğu belirlenmiştir. Babaların algılarının aile ile daha çok zaman geçirebilme, aile bireyleriyle ortak saatlerin daha çok olması, işe gidip gelindiğinde aile bireylerine sarılamama, onlarla sosyal mesafeyi korumaya çalışma, yürüyüş yapamama, temizliğe dikkat etme şeklinde olduğu tespit edilmiştir. Büyükanne/ büyükbabaların algılarının ise hareketsiz bir yaşam dönemi, çocukları ve torunları görememe, daha çok dinlenme, kitap/gazete okuma, Allah'ın bir sınavı kategorilerinde toplandığı görülmüştür. Çocuklar üzerindeki olumlu etkiler; anne/baba ile daha çok zaman birlikte zaman geçirme, çevrimiçi eğitimden faydalanma şeklinde gruplandırılırken, olumsuz etkilerin ise özgürlüğün kısıtlanması, spor yapamama, internet ve televizyon ile daha çok zaman harcama, arkadaşları ile görüşememe şeklinde gruplandırılmıştır. Ayrıca çalışma sonucuna dayalı olarak somesfobi yeni bir kavram olarak önerilmiş ve kuramsal açıdan açıklanmaya çalışılmıştır. Çalışma doğrultusunda alandaki araştırmacılara pandemi dönemlerinde bireylerin ruh sağlığını koruma ve destekleme amaçlı eğitim programlarının geliştirilerek, işlevselliğinin test edilmesine yönelik çalışmaların planlanması önerilebilir.
SAĞLIK BİLİMLERİ FAKÜLTESİ ÖĞRENCİLERİNİN FONKSİYONEL BESİNLERE YÖNELİK TUTUMLARININ VE BAZI FONKSİYONEL BESİNLERİ TÜKETİM SIKLIKLARININ BELİRLENMESİ
Authors: İRKİN Reyhan , BATU Zehra 
Published: August 2021

Bu çalışmada İzmir ilinde eğitim veren bir kamu üniversitesinde eğitim alan sağlık bilimleri fakültesi öğrencilerinin fonksiyonel besinlere yönelik tutumlarının, bilgi düzeylerinin ve bazı fonksiyonel besinleri tüketim sıklıklarının belirlenmesi amaçlanmıştır. Çalışma 290 öğrenci (%18.6 erkek, %81.4 kadın) ile gerçekleştirilmiştir. Araştırmada veri toplama aracı olarak anket formu ve Fonksiyonel Besin Bilgi Düzeylerini Belirleme Ölçeği uygulanmıştır. Öğrencilerin %42.4’ü fonksiyonel besinleri daha önce hiç duymadığını belirtmiş, %5.2’sinin fonksiyonel besin bilgi düzeyinin yetersiz düzeyde olduğu bulunmuştur. Fonksiyonel besinlerle ilgili güvenilir kaynak olarak katılımcıların %45.9’u uzman görüşünü, %43.8’i bilimsel yayınları göstermiştir. Fonksiyonel besinlerin bilinirliğinin fonksiyonel besin tüketimini artırdığı (p&lt;0.001), fonksiyonel besin bilgi düzeyi puanının beslenme ve diyetetik bölümü öğrencilerinde daha yüksek olduğu (p=0.004), fonksiyonel besinleri tüketmeyi düşünme konusunda aylık gelir açısından gruplar arasında farklılık olmadığı (p=0.480), beslenmenin sağlık üzerinde büyük etkisi olduğu yönünde görüş bildirenlerin fonksiyonel besin tüketmeyi düşünme oranının daha fazla olduğu (p=0.001) belirlenmiştir. Öğrencilerin en sık tükettikleri fonksiyonel besinler domates ve zeytinyağı olarak, en az bilinen fonksiyonel besinler ise zenginleştirilmiş yumurta ve ekinezya olarak belirlenmiştir. Sağlık bilimleri fakültesi öğrencilerinin fonksiyonel besinler konusunda bilgilendirilmeleri önerilmektedir.
Ideologisasi Partai Islam Masyumi di Indonesia
Authors: Argenti Gili 
Published: August 2021

Kemunculan Masyumi Reborn awal Maret 2020 kembali mengingatkan publik politik Indonesia mengenai Partai Masyumi. Partai politik Islam yang pernah berjaya pada masa demokrasi liberal atau parlementer ini diklaim sangat ideologis bila dibandingkan dengan partai-partai Islam saat ini. Tulisan ini merupakan studi mengenai sejarah, kiprah politik dan ideologi Partai Masyumi ketika masa pemerintahan Orde Lama. Tulisan ini memfokuskan perdebatan di Konstituente. Penelitian ini adalah tipe penelitian deskriptif yang menggunakan literatur untuk mendapatkan data, dan kemudian dianalisis berdasarkan landasan teori yang digunakan untuk membingkai data yang dianalisis. Landasan teoritik yang digunakan adalah partai politik Islam, ideologi dan relasi Islam dengan negara. Berdasarkan hasil penelitian literatur ternyata ditemukan terjadi pergeseran ideologi Masyumi di akhir masa sidang konstituante, mereka bergeser sedikit ke arah subtansi dari sebelumnya ideologinya bercorak formalis. Meski mengalami kegagalan di Konstituante pengaruh dari ideologisasi Masyumi ini masih terasa sampai saat ini, pengaruhnya tidak saja di kelompok Islam politik di Indonesia, tetapi juga di negara Malaysia.Kata Kunci: Partai Masyumi, Ideologi, Partai Politik Islam, Konstituante
Partisipasi Politik Pemilih Milenial pada Pemilu di Indonesia
Authors: Zulkarnaen Fizher , Adara Adea Suci , Rahmawati Alvi , Wartadiayu Lidia , Pamungkas Mochamad Dimas 
Published: August 2021

Pemilu merupakan suatu bentuk sarana berdemokrasi dalam suatu Negara. Pemilu juga merupakan bentuk pemenuhan hak warga Negara dalam mengeluarkan suara. Dan suatu Negara tidak dapat terlepas dari generasi Milenial sebagai estafet penerus pembangunan suatu Negara di masa depan selain itu tingginya kewenangan hak pilih dikalangan Milenial menjadi salah satu ketertarikan tersendiri bagi setiap tim sukses, hanya saja pemilih Milenial dengan kemajuan teknologi membuat beberapa miss informasi yang didapat generasi milenial yang tentunya akan berpengaruh terhadap calon pilihannya selin itu tim sukses memiliki tantangan tersendiri untuk mengajak mereka memilih calon yang masing tim sukses siapkan. Artikel ini dibuat bertujuan untuk memberikan pengetahuan tentang bagaimana partisipasi Generasi Milenial dalam mempergunakan hak suara mereka pada penyelenggaraan pemilu. Dengan pendekatan kualitatif serta metode studi literatur yaitu dengan mencari berbagai referensi mengenai partisipasi pemilih Milenial di Indonesia baik itu dari sumber buku dan artikel ilmiah. Dimana penelitian ini menyimpulkan bahwa Partisipasi generasi Milenial ini sangat berpengaruh pada tingkat keterpilihan suatu calon yang di usung dan untuk mejaga roh demokrasi tetap diperlukannnya beberapa strategi untuk meningkatkan pemilih pada sector Milenial.
Half-integer Shapiro-steps in superconducting qubit with a π-Josephson junction
Authors: Mori Michiyasu , Maekawa Sadamichi 
Published: August 2021

Abstract
A superconducting quantum interference device (SQUID) comprising 0- and π-Josephson junctions (JJs), called π-SQUID, is studied by the resistively shunted junction model. The π-SQUID shows half-integer Shapiro-steps (SS) under microwave irradiation at the voltage V =

(
ℏ

/

2
e
)
Ω
(
n

/

2
)

, with angular frequency Ω and half-integer n/2 in addition to integer n. We show that the π-SQUID can be a π-qubit with spontaneous loop currents by which the half-integer SS are induced. Making the 0- and π-JJs equivalent is a key for the half-integer SS and realizing the π-qubit.
Limitation of the distribution of the latent form of potato phomosis with the use of biofungicides
Authors: Andriychuk T. , Skoreyko A. , Lisnychiy V. 
Published: August 2021

Goal. To establish the spread of the latent form of the phomosis pathogen in the western region of the Forest-Steppe zone and to study the possibility of crop protection through the use of biofungicides.
Methods. In the process of work used laboratory (cultivation of pathogens) and field (analysis, processing of tuber material).
Results. The results of research conducted during 2019—2020 to detect latent infection of phomosis rot of potatoes in the western part of the forest-steppe zone of Ukraine (Zakarpattia, Chernivtsi, Ivano-Frankivsk regions) are presented. Within two years, the highest damage to tubers by latent phomosis infection was observed in varieties Yavir and Vodogray in the Ukrainian Carpathians (Ivano-Frankivsk region, Verkhovyna district, Bystrets village; Zakarpattia region, Mizhhirya district, Maidan village; Zakarpattia region, Rakhiv district, Yasinya village; Chernivtsi region, Vyzhnytskyi district, Berehomet village), which reached 25—33 and 21.0—23.0%, respectively. In the plain zone of Chernivtsi region (Hertsaiv district, Bukivka village; Novoselytsia district, UkrNDSKR IZR) a significantly lower percentage of tuber lesions with a latent form of the disease was observed. The minimum rates of tuber damage, both latent form of phomosis and with existing external signs, were observed in the variety Slovyanka and were in the plain zone 4.5—5.5% and 7.0—8.0 in the mountain. When treating tubers with biofungicides, the least pathogen tuber damage was observed in the variants using Trichodermin-Bio, PhytodoDoctor and Planriz, where the number of infected tubers was 10.0, 11.0 and 12.5%, respectively. In the control variant, the percentage of affected tubers with latent form of phomosis was 2.1—3.2 times higher than in the experimental ones. The effectiveness of biofungicides was greatest when using Trichodermin-Bio and PhytoDoctor and was 68.3 and 65.1%, respectively. Less effective drug against the latent form of phomosis, compared with other options was Hetomic, where its technical efficiency was 52.4%.
Conclusions. The causative agent of phomotic rot of potatoes (Phoma exigua var. Exigua) in latent form is a widespread pathogen in the western part of the Forest-Steppe zone. To limit the spread of latent infection of phomos, biological drugs Hetomik (0.4 kg/ha) were used, Gaupbsin (5 l/t), Planriz (2 l/t), Trichodermin-Bio (2 l/t), PhytoDoctor (0.3 l/t), which helped to reduce the damage to the tubers by a latent form of the disease by 2.1—3.2 times compared to the control.