bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consequences of Extracellular Matrix Remodeling in Headway and Metastasis of Cancer along with Novel Immunotherapies: A Great Promise for Future Endeavor
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: July 2021

:
Tissues are progressively molded by bidirectional correspondence between denizen cells and extracellular
matrix (ECM) via cell-matrix connections along with ECM remodeling. The composition and association of ECM are
spatiotemporally directed to control cell conduct and differentiation; however, dysregulation of ECM dynamics
prompts the development of diseases, for example, cancer. Emerging information demonstrates that hypoxia may have
decisive roles in metastasis. In addition, the sprawling nature of neoplastic cells and chaotic angiogenesis are increasingly
influencing microcirculation as well as altering the concentration of oxygen. In various regions of the tumor
microenvironment, hypoxia, an essential player in the multistep phase of cancer metastasis, is necessary. Hypoxia can
be turned into an advantage for selective cancer therapy because it is much more severe in tumors than in normal tissues.
Cellular matrix gives signaling cues that control cell behavior and organize cells' elements in tissue development
and homeostasis. The interplay between intrinsic factors of cancer cells themselves, including their genotype and signaling
networks, and extrinsic factors of tumor stroma, for example, ECM and ECM remodeling, together decide the
destiny and behavior of tumor cells. Tumor matrix encourages the development, endurance, and invasion of neoplastic
and immune cell activities to drive metastasis and debilitate treatment. Incipient evidence recommends essential parts
of tumor ECM segments and their remodeling in controlling each progression of the cancer-immunity cycle. Scientists
have discovered that tumor matrix dynamics as well as matrix remodeling in perspective to anti-tumor immune reactions
are especially important for matrix-based biomarkers recognition and followed by immunotherapy and targeting
specific drugs.
Insulin Therapy and Outcome of Coronavirus Disease 2019 (COVID-19):
A Systematic Review, Meta-Analysis, and Meta-Regression
Authors: Hariyanto Timotius Ivan , Lugito Nata Pratama Hardjo , Yanto Theo Audi , Siregar Jeremia Immanuel , Kurniawan Andree 
Published: July 2021

Background:
Currently, the relationship between insulin therapy and COVID-19 outcome
is not yet established. Our study aims to evaluate the possible association between insulin
and the composite poor outcome of COVID-19.

Methods:
We systematically searched the PubMed and Europe PMC database using specific keywords
related to our aims until December 12th, 2020. All articles published on COVID-19 and insulin
were retrieved. Statistical analysis was done using Review Manager 5.4 and Comprehensive
Meta-Analysis version 3 software.

Results:
Our pooled analysis showed that insulin use was associated with composite poor outcomes
of COVID-19 [OR 2.06 (95% CI 1.70 – 2.48), p < 0.00001, I2 = 83%, random-effect modelling],
and its subgroup which comprised of risk of COVID-19 [OR 1.70 (95% CI 1.40 – 2.08), p
< 0.00001, I2 = 34%, random-effect modelling], severe COVID-19 [OR 2.30 (95% CI 1.60 –
3.30), p < 0.00001, I2 = 88%, random-effect modelling], and mortality [OR 2.14 (95% CI 1.47 –
3.10), p < 0.0001, I2 = 85%, random-effect modelling]. Meta-regression showed that the association
was influenced by age (p = 0.008), but not by diabetes p = 0.423) and cardiovascular disease
(p = 0.086).

Conclusion:
Physicians should be more aware and take extra precautions with diabetes patients
who use insulin therapy.
Bioinformatics Analysis and Identification of Phytoene Synthase Gene in Microalgae
Authors: Shaker Saeedeh , Morowvat Mohammad Hossein , Ghasemi Younes 
Published: July 2021

Background:
Carotenoids are known as lipophilic secondary metabolites with important
biological activities, which are mostly used in the food and pharmaceutical industry. They contribute
to the colours of many fruits and flowers. Studies on the biosynthetic pathways of isoprenoids
and carotenoids are still scarce, especially in microalgae and are limited to specic groups.
Dunaliella spp. in Chlorophyta taxon of algae, the 2-C-methyl-D-erythritol 4-phosphate/
1-deoxy-D-xylulose 5-phosphate (DOXP/MEP) is the synthesis pathway of sterols and
carotenoids.

Objectives:
In this study, we used 12 Psy gene sequences in Dunaliella sp., also Scenedesmus acutus
and Diospyros kaki to investigate a genome-wide search. The results are useful for better identification
of carotenoids metabolisms, and increasing the production rate of beta-carotene in pharmaceutical,
food and industrial processes.

Methods:
Phytoene synthase (Psy) from Dunaliella spp. was selected as the rst regulatory point in
the carotenoids pathway that catalysis the formation of geranylgeranyl pyrophosphate in isoprenoid
biosynthesis. Structural, evolutionary and physics-chemical characteristics were investigated, using
various bioinformatics tools and computer techniques. Moreover, some recently published patents
were also regarded.

Results:
The maximum length of the conserved motif was 5167 bp for Dunaliella. sp.
(DQ463306.1) and the smallest length of the conserved motif was 416 bp belonging to D. salina
(JQ762451.1). The average molecular weight of species was 41820.53 Da. The theoretical pI of
species varied from 4.87 to 9.65, indicating vernation in the acidic nature. Two strains of D. bardawil
(U91900.1 and EU328287.1) showed just a long-distance relationship with all other Dunaliella
strains. Whilst, D. parva displayed the furthest vicinity with all the studied strains.

Conclusion:
Our study highlighted the Psy regulatory mechanism, as a key factor in the
carotenoids pathway, to facilitate genetic and metabolic engineering studies. The obtained tree-dimensional
arrangement of the amino acids revealed the regional structures and folding of the diverse
segments of helices, sheets and turns. This information is a key point to unveil the protein's
operation mechanism. Besides, we confirmed the suitability of bioinformatic approaches for analysing
the gene structures and identifying the new Psy genes in unstudied microalgal strains.
Behavior Hollow Concrete Reinforced Slab with The Utilization of Polyvivyl Chloride Pipe as a Cavity
Authors: Trias Atmadja Wahyu Mahendra , Parung Herman , Irmawaty Rita , Amiruddin A.Arwin 
Published: July 2021

Background:
Slab weight can be reduced by replacing the amount of concrete in the tensile area with the utilization of modification polyvinyl chloride pipe as cavity without reducing the flexural strength because the nature of concrete is weak against tensile strength.

Methods:
This research with the experimental method using static load. The setting of tools refers to the American Society for Testing and Material E 2322, bending analysis is used moment coefficient method, deflection by applying Ugural and Navier method, and shear analysis using Indonesia National Standard 03-2847-2019.

Results:
The specimens consist of solid plates with a thickness of 140 mm and hollow plates with a thickness of 140 mm and 159 mm. The maximum load capacity solid plate is 410.642 kN, while the hollow plates (140 mm) is 335.18 kN, and for the hollow plates 159 mm is 396.257 kN. The solid plate’s stiffness is 16.321, the hollow plates 140 mm is 14.787 and the hollow plate 159 mm is 24.194, while the ductility is 1.993 on solid plate, the hollow plate 140 mm is 2.014, and the hollow plate 159 mm is 1.862. The solid plate’s damage is flexural, while the two hollow plates are a combination of bending and shear damage. The crack pattern on the solid plates is flexible, while the crack pattern on both hollow plates is a combination of flexural cracks and shear cracks.

Conclusion:
The use of modified polyvinyl chloride pipes can be recommended in the structure of the plate. There is a small, insignificant difference in the flexural behaviour between the solid plate and hollow concrete reinforced slab with the utilization of Polyvinyl Chloride.
The Comparison of Biofilm Formation, Mechanical and Chemical Properties between Glass Ionomer Cement and Giomer
Authors: Alinda Sylva Dinie , Margono Anggraini , Putranto Aditya Wisnu , Maharti Ike Dwi , Amalina Retno , Rahmi Sherly Firsta 
Published: July 2021

Aims:
The aim of this study was to compare compressive strength and its correlation with the surface morphology and chemical elements of GIC and Giomer, as well as to determine the fluoride amount effect on the bacterial biofilm formation of GIC and Giomer.

Background:
The liability of Glass Ionomer Cement (GIC) mechanical properties is overcome with better antibacterial properties among restorative materials. Another fluoride-releasing restorative material, such as Giomer, has been discovered and is expected to overcome the issues with GIC’s mechanical properties; however, no research has been conducted related to antibacterial properties in Giomer.

Objective:
To compare compressive strength and its correlation with the surface morphology and chemical elements, then determine the fluoride amount effect on the bacterial biofilm formation of GIC and Giomer.

Methods:
Sixteen specimens of GIC and Giomer were prepared for a compressive strength measurement with the Universal Testing Machine. Sixteen specimens of GIC and Giomer were incubated for three days with the Streptococcus mutans culture at 37°C. The bacterial colonization was calculated using the Colony Forming Unit (CFU) and bacterial adhesion was calculated using a Scanning Electron Microscope (SEM). The mechanical properties’ compressive strength measurement, surface morphology, and chemical elements analyses were performed using SEM-EDX.

Results:
The compressive strength of Giomer was higher than GIC (P=0.001). The higher compressive strength of Giomer was reflected by a predominant regular surface, fewer voids, smaller and denser particles, and a higher content of silica and carbon. The bacterial biofilm on the surface of Giomer was higher than GIC, although there was no significant difference. GIC and Giomer have identical chemical elements: C, O, F, Na, Al, Si, P, and Ca.

Conclusion:
The compressive strength of Giomer is better than GIC; however, the biofilm formation of Giomer is higher than GIC, whereas GIC has a higher fluoride content but inferior in surfaces morphology characteristic
Green Synthesis of Silver Chloride Nanoparticles using Phlomoides Labiosa
(Bunge) Adylov, Kamelin & Makhm Herbal Extract by Investigating
Antioxidant Properties and Antibacterial Effects
Authors: Arkani Toktam , Firoznia Ali , Izanloo Cobra 
Published: July 2021

Background:
Considering the high cost of nano-particles chemical synthesis and bacteria’s
high resistance against antibiotics, investigating silver particles biosynthesis and their effect
on clinical and standard strains of different bacteria is very important.

Objective:
This study investigates the feasibility of green synthesis of silver chloride nanoparticles
by labiosa (Bunge) Adylov, Kamelin & Makhm Phlomoides (Eremostachys labiosa
Bunge) herbal extract and Phlomoides binaludensis Salmaki & Joharchi (Binaloud Cistanche tubulosa)
plant.

Methods:
Scanning Electron Microscope (SEM), X-Ray Diffraction (XRD), UV-Visible Spectroscopy,
and Energy-Dispersive X-ray Spectroscopy (EDS) are used for nano-particles characterization.
The antibacterial property of extracts and synthesized nano-particles was evaluated
against Staphylococcus aureus, Bacillus cereus and Escherichia coli by agar disk diffusion and
well diffusion, respectively. As antioxidants existing in plants are expected to act as regenerators
in nano-particles synthesis, the plants used were investigated considering the existence of antioxidants
through two DPPH and FRAP methods. Total values of phenol and IC50 were determined
by the extract of considered plants.

Results:
The results showed that what has been successful in nano-particles synthesis is silver
chloride nano-particles synthesis, which is due to the existence of chlorinated compounds in the
herbal extract. Synthesized nano-particles are spherical, and their size is in the range of 27-35 nm,
and synthesized nano-particles were distributed consistently. Also nano-particles enjoy significant
antibacterial activity.

Conclusion:
IC50 was 0.56 mg/ml and 0.96 mg/ml for the aerial organs of Eremostachys labiosa
Bunge and Binaloud Cistanche tubulosa, respectively, in this study, while it was 0.38 mg/ml for
BHT synthetic antioxidant. Also, iron regeneration ability reported 255.990 and 64.110 Fe ion
mmol/extract gr by the extracts.
INFORMATION GAIN PADA ALGORITMA C4.5 UNTUK KLASIFIKASI PENERIMAAN BANTUAN PANGAN NON TUNAI (BPNT)
Authors: Saputra Rizal Amegia , Wasiyanti Sri , Pribadi Denny 
Published: July 2021

Masalah kemiskinan diberbagai belahan dunia khususnya indonesia menjadi persoalan serius yang menjadi pusat perhatian pemerintah saat ini. Berbagai cara telah di lakukan oleh pemerintah untuk menekan angka kemiskinan meningkat, salah satunya memberikan bantuan kepada masyarakat miskin melalui perogram Bantuan Pangan Non Tunai (BPNT). Namun pemangku kepentingan memiliki permasalahan yang terjadi dilapangan yaitu sulitnya mengklasifikasikan data yang menerima bantuan sehingganya mengakibatkan kurang tepatnya sasaran dalam memberikan bantuan. Dalam penelitian ini menerapkan algoritma C4.5 dengan split kriteria information gain, algoritma C4.5 adalah salahsatu algoritma terbaik pada algoritma klasifikasi, dan dataset yang didapat pada tahun 2018 pada Desa Nagrak Utara Sukabumi sebanyak 130 data. Model pohon keputusan yang dihasilkan dari penerapan algoritma C4.5 yaitu menghasilkan akurasi sebesar 91.54% dengan nilai AUC 0.986, dengan demikian algoritma C4.5 untuk klasifikasi penentukan penerimaan BPNT itu termasuk algoritma Sangat Baik, karena range AUC diantara 0.90-1.00.
MENINGKATKAN KEAWETAN JAMU TRADISIONAL SEBAGAI UPAYA OPTIMALISASI PRODUK UNGGULAN DESA KARANGREJO
Authors: Trianti Khoiriyah , Sari Celvia Gusmia , Khasanah Shofia Uswatul , Imandasari Rizqi , Cholifah Junika Nur , Udi Mohalimas' , Cintya Oktriaayu Mega 
Published: July 2021

Program Inovasi Desa merupakan pendampingan yang dilakukan untuk mendorong pemanfaatan produk unggulan dengan meningkatkan kualitas supaya lebih baik lagi. Program inovasi desa merupakan kegiatan yang dapat meningkatkan produk unggulan sebagai bentuk upaya pengabdian kepada masyarakat untuk meningkatkan kesejahteraan dan perekonomian masyarakat pada masa pandemi covid-19.
Pengabdian kepada masyarakat KKN PPM edisi covid-19 bertempatkan di Desa Karangrejo, Kecamatan Kromengan, Kabupaten Malang. Penduduk asli Desa Karangrejo mayoritas pedagang jamu gendong. Himbauan pemerintah melarang warganya untuk beraktivitas diluar terlebih berkumpul dengan banyak orang guna mencegah penularan virus Covid-19 berdampak pada pedagang jamu tersebut. Pedagang jamu mengalami dampak yang luar biasa mereka tidak bisa menjual jamu dengan cara berkeliling seperti biasa sementara jamu gendong tersebut hanya bertahan sepekan saja. Hal ini juga akan menjadi kendala apabila jamu tersebut dijual secara online karena batas waktu bertahannya relatif pendek. Sehingga, kami memberikan inovasi terhadap pengemasan jamu supaya dapat bertahhan lebih lama yaitu dijadikan serbuk jamu dan dikemas secara menarik.
A SPEECH ACT ANALYSIS OF WRITTEN ADVERTISEMENT OF COSMETIC BRAND IN INDONESIA
Authors: Aditria Nanda , Rizqiya Rissa San 
Published: July 2021

Advertising is a tool for creating communication and can promote goods or other products to everyone or what customers call using binding language. Every language uses good language to attract customers. The main purpose of advertising is the point of view to promote and promise an item.This study used qualitative research from several cosmetic advertisements. This ad uses 16 types of speech acts, and out of 16 types of speech acts, only 10 brands are taken from cosmetic advertisements to attract or invite products to buy. And advertising results from 10 cosmetic brands in Indonesia only got 7% speech statement, 30% information, 9% claim, 19% suggestion, 9% suggestion, 2% argument, 2% accusation, 2% referral, 16% directive, persuasion 2%, promise 2%. From this result that most cosmetic brands in Indonesia use information, to make it more interesting for buyers to find out more information than other advertisements. Keyword :A speech act advertisement, cosmetic.
THE APPLICATION OF INSTRUCTIONAL MEDIA IN TEACHING ENGLISH TO YOUNG LEARNERS
Authors: Winola Tiya 
Published: July 2021

In Indonesia, English is a foreign language, hence not easy to teach English to young learner in Indonesia, thus, need something interesting to teach English to young learners, one of which uses instructional media. Instructional media as a tool needed to facilitate the teachers in presenting the material, but many English teachers in Indonesia find it difficult to use instructional media in the classroom. This study aims to (1) how the teacher applied the instructional media in the classroom. (2) to investigate problems faced by the teacher, and (3) elaborate the teacher's strategies in solving problems using the instructional media. This study was conducted a case study design, by using observation and interviews to collect data. In the investigation teachers do not have free access to use the media provided at school. Thus, they faced obstacles to provide proper media in classroom. Therefore this paper described certain strategies to solve teacher problems in using instructional media in the class. Keywords: Teaching English, Instructional media, Young learners
Türkiye Ulusal Spor Federasyonlarında Ters VZA İle Kaynak Tahsisi
Authors: ÇAKIR Gökhan , ÇAKIR Süleyman 
Published: July 2021

Sporcular, antrenörler, sponsorlar ve kamu otoritelerini içeren paydaşlarının beklentilerini karşılamak için ulusal spor federasyonlarının (NSF'ler) performans ölçüm modellerini üstlenmesi gerekmektedir. Bu çalışmada Ters Veri Zarflama Analizi(InDEA) modelleri kullanılarak 18. Akdeniz Oyunları'na katılan Türkiye'den 15 spor federasyonunun etkinlik analizi yapılmıştır. Sonuçlar, spor federasyonlarının ortalama verimliliğinin oldukça düşük olduğunu ortaya koymuştur. Önerilen InDEA modeli, NSF'lerin ve farklı organizasyonların yöneticilerine üretim analizi, performans ölçümü, kaynak planlama ve stratejik yönetim konusunda yardımcı olabilir.
The Association of Fried Meat Consumption With the Gut Microbiota and Fecal Metabolites and Its Impact on Glucose Homoeostasis, Intestinal Endotoxin Levels, and Systemic Inflammation: A Randomized Controlled-Feeding Trial
Authors: Gao Jian , Guo Xiaoyu , Wei Wei , Li Ran , Hu Ke , Liu Xin , Jiang Wenbo , Liu Siyao , Wang Weiqi , Sun Hu , Wu Huanyu , Zhang Yuntao , Gu Wenbo , Li Ying , Sun Changhao , Han Tianshu 
Published: July 2021

OBJECTIVE
This randomized controlled-feeding trial aimed to determine the impact of fried meat intake on the gut microbiota and fecal cometabolites and whether such impacts influenced host glucose homoeostasis, intestinal endotoxin levels, and systemic inflammation.

RESEARCH DESIGN AND METHODS
A total of 117 overweight adults were randomized into two groups. Fifty-nine participants were provided fried meat four times per week, and 58 participants were restricted from fried meat intake, while holding food group and nutrient compositions constant, for 4 weeks. The gut microbiota was analyzed by 16S rRNA sequencing. Glucose and insulin concentrations at 0, 30, 60, and 120 min of an oral glucose tolerance test, fecal microbiota-host cometabolite levels, and intestinal endotoxin and inflammation serum biomarker levels were measured. The area under the curve (AUC) for insulin, insulinogenic index (IGI), and muscle insulin resistance index (MIRI) were calculated.

RESULTS
The participants who consumed fried meat had lower IGI values than the control subjects, but they had higher MIRI and AUC values of insulin and lipopolysaccharide (LPS), TNF-α, IL-10, and IL-1β levels (P &lt; 0.05). Fried meat intake lowered microbial community richness and decreased Lachnospiraceae and Flavonifractor abundances while increasing Dialister, Dorea, and Veillonella abundances (P FDR &lt;0.05), provoking a significant shift in the fecal cometabolite profile, with lower 3-indolepropionic acid, valeric acid, and butyric acid concentrations and higher carnitine and methylglutaric acid concentrations (P FDR &lt;0.05). Changes in these cometabolite levels were significantly associated with changes in IGI and MIRI values and LPS, FGF21, TNF-α, IL-1β, and IL-10 levels (P &lt; 0.05).

CONCLUSIONS
Fried meat intake impaired glucose homoeostasis and increased intestinal endotoxin and systemic inflammation levels by influencing the gut microbiota and microbial-host cometabolites.
The influence of demographic factors and financial literacy on the financial behavior
Authors: Iriani Agustina Rosa , Rahayu Caecilia Wahyu Estining , Rahmawati Christina Heti Tri 
Published: July 2021

Penelitian ini bertujuan untuk mengetahui (1) pengaruh faktor demografi terhadap perilaku keuangan mahasiswa Fakultas Ekonomi Universitas Sanata Dharma; dan (2) pengaruh literasi keuangan terhadap perilaku keuangan mahasiswa Fakultas Ekonomi Universitas Sanata Dharma. Jenis penelitian ini menggunakan metode survei. Penelitian ini membagikan 100 kuesioner untuk memperoleh data responden. Teknik pengambilan sampel menggunakan purposive sampling. Teknik analisis data yang digunakan adalah analisis crosstabulation dan analisis Chi Square. Hasil penelitian ini menunjukkan bahwa faktor demografi (pekerjaan orangtua, pendidikan orangtua, dan pendapatan orangtua) tidak berpengaruh terhadap perilaku keuangan mahasiswa Fakultas Ekonomi Universitas Sanata Dharma. Sedangkan, literasi keuangan berpengaruh terhadap perilaku keuangan mahasiswa Fakultas Ekonomi Universitas Sanata Dharma. Implikasi penelitian ini, meningkatnya literasi keuangan mahasiswa Fakultas Ekonomi Universitas Sanata Dharma diharapkan dapat meningkatkan perilaku keuangan mahasiswa menjadi lebih baik sehingga mampu meningkatkan kesejahteraannya.Kata kunci: Faktor demografi; literasi keuangan, perilaku keuangan
Determinant of sharia banks profitability in Indonesia: The moderating effect of non performing financing
Authors: Muchtar Darmawati , Azhari Fahmi , Bensaadi Iswadi 
Published: July 2021

This study aims to analyze the effect of capital adequacy ratio (CAR), operating cost of operating income (BOPO) on profitability and examine the role of non performing financing (NPF) in influencing the relationship between CAR and BOPO on profitability of sharia bank in Indonesia. The data used in this study is a panel data that consisting of 10 sharia banks for the period 2010-2018 with 99 observations. The method of analysis data is multiple regression analysis with random effect model. The results of this study in model one show that BOPO has negative and significantly affects profitability, meanwhile CAR has positive but insignificant effect, while and NPF has negative effect on profitability but insignificant in model two. Furthermore, when NPF interected with CAR shows interesting results, in which CAR has negative and significant effect on profitability, while BOPO is still consistent with negative and significant effect on profitability. This suggests that the NPF moderates the influence of CAR and BOPO on profitability. This implies that increase NPF would decrease the effect of CAR on profitability and the effect of BOPO on profitability would be strangted of syaria bank in Indonesia. Keywords: Capital adequacy ratio; BOPO; non performing financing, profitability