bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Wilms' Renal Tumors In Children:A 139 Cases Series
Authors: Fang Yi Wei , Song Hong Cheng , Sun Ning , Zhang Wei Ping 
Published: December 2021

Abstract
Background:Pediatric non-Wilms renal tumors (NWRTs) which comprise a small proportion of renal tumors,are a heterogeneous group of neoplasms with variable malignant potential, mortality, and response to treatment.This study aimed to determine the clinical characteristics, management and prognosis of children with non-Wilms' renal tumors(NWRTs). Methods:Medical records of all patients (n = 139) treated for NWRTs over a 12-year period (2008.01–2019.10) at a single center were reviewed retrospectively.Results:The histopathological groups of NWRTs included malignant rhabdoid tumor of the kidney(MRTK)(n: 30, 21.6%), renal cell cancer(RCC)(n: 26,18.7%), clear cell sarcoma of the kidney(CCSK)(n: 24,17.3%), congenital mesoblastic nephroma(CMN)(n: 21,15.1%), cystic nephroma(CN)(n: 16,11.5%),metanephric tumours(n: 12, 8.6%), renal angiomyoliporma(RAML)(n: 3, 2.2%), renal primitive neuroectodermal tumor(rPNET)(n: 2, 1.4%), renal hemangioma(n: 2, 1.4%), inflammatory myofibroblastic tumor(IMT)(n: 2, 1.4%), ossifying renal tumor of infancy(ORTI)(n: 1, 0.7%). 123 children were followed up with an average of 42 months. 16 children were lost to follow-up. Tumor-free survival was observed in 94 children. 28 children(22.8%) were died.Conclusions:Pediatric NWRTs comprises 19.1% of all renal tumors in our single center. Accurate diagnoses along with appropriate management are important factors in improving patients outcome. The mainstay treatment of malignant NWRTs including MRTK,CCSK,RCC and PNET is comprehensive treatment. The mainstay treatment of benign NWRTs including RAML,CN, ORTI, CMN,metanephric tumours, and renal hemangioma is surgical resection alone.
Food Consumption Patterns, Breakfast, Meals with Family and Associations with Common Mental Disorders in Adolescents: A School-Based Cross-Sectional Study
Authors: Gratão Lucia Helena Almeida , Pessoa Milene Cristine , Silva Thales Philipe Rodrigues da , Rocha Luana Lara , Inácio Monique Louise Cassimiro , de Oliveira Tatiana Resende Prado Rangel , Cunha Cristiane de Freitas , Mendes Larissa Loures 
Published: December 2021

Abstract
BackgroundAdolescence is a period of transition and vulnerabilities, in which mental illnesses can develop more easily. The objective of this work is to verify the association between food consumption patterns and the presence of Common Mental Disorders in Brazilian adolescents. MethodsThis is a cross-sectional study which analyzed data from 71,553 Brazilian adolescents aged 12-17 years, from the ERICA Study. Principal Component Analysis was performed to identify Food Consumption Patterns, and Logistic Regression Models were performed to identify the associations between Common Mental Disorders, Food Consumption Patterns, and eating practices that are breakfast consumption and practice of having meals accompanied by family. ResultsTwo patterns were found, a Healthy Food Consumption Pattern and a Unhealthy Food Consumption Pattern. Adolescents classified in the second (OR: 0.77; 95% CI 0.68 - 0.88) or third (OR: 0.87; 95% CI 0.74 - 0.95) tercile of the Healthy Food Consumption Pattern had a lower chance of having Common Mental Disorders, while those who belonged to the third tercile of the Unhealthy Food Consumption Pattern (OR: 1.22; 95% CI 1.02 - 1.42), had an increased chance of having Common Mental Disorders. Eating breakfast sometimes (OR: 0.69; 95% CI 0.59 - 0.80) or almost every day/every day (OR: 0.52; 95% CI 0.46 - 0.59), and the practice of having the main meals with the family sometimes (OR: 0.64; 95% CI 0.54 - 0.75) or almost every day/every day (OR: 0.48; 95% CI 0.40-0.55), decreased the chance for Common Mental Disorders.ConclusionStrategies to promote the mental health of adolescents as the adoption of healthy eating practices must be strengthened and promoted.
Spontaneous Regression of Tumor in an Optic Pathway Glioma Patient With Diencephalic Syndrome: Case Report and Literature Review
Authors: Luo Rutao , Zhang Tianlei , Yang Wei , Ji Yuanqi , Sun Hailang , Li Dapeng , Ge Ming 
Published: December 2021

Abstract
Background: Diencephalic syndrome (DS) can cause failure to thrive in pediatrics, which is mostly found in optic pathway gliomas (OPGs) patients. OPGs patients with DS always show a poor outcome. Case presentation: We present the case of an OPG patient with DS who got a spontaneous regression without any treatment. A 6-month-old girl presented with failure to thrive for two months and visual dysfunction with bilateral horizontal nystagmus. MRI demonstrated a 42mm*37mm*36mm enhanced and lobulated lesion located in the sellar region with a clear boundary with surrounding tissues. OPG and DS was diagnosed according to her radiological examination and manifestation. Conservative follow-up was given. There was a spontaneous decrease in tumor size during follow-up. Symptom improves and the patient continues to have a good quality of life despite a moderate dysfunction of her left eye.Conclusions: Conservative observation can be used as a treatment for some OPG patients, body weight may be a marker of the growth of tumor in OPG patients with DS.
Composition And Key-Influencing Factors of Bacterial Communities Active In Sulfur Cycling of Soda Lake Sediments
Authors: Li Xiangyuan , Yang Maohua , Mu Tingzhen , Miao Delu , Liu Jinlong , Xing Jianmin 
Published: December 2021

Abstract
Bacteria are important participants in sulfur cycle of the extremely haloalkaline environment, e.g. soda lakes. The effects of physicochemical factors on the composition of sulfide-oxidizing bacteria (SOB) and sulfate-reducing bacteria (SRB) in soda lakes have remained elusive. Here, we surveyed the communities structure of total bacteria, SOB and SRB based on 16S rRNA, soxB and dsrB gene sequencing, respectively, in five soda lakes with different physicochemical factors. The results showed that the dominant bacteria in soda lakes sediments belonged to the phyla Proteobacteria, Bacteroidetes, Halanaerobiaeota, Firmicutes and Actinobacteria. SOB and SRB were widely distributed in lakes with different physicochemical characteristics，and the community composition were different . In general, salinity and inorganic nitrogen sources (NH4+-N, NO3--N) were the most significant factors. Specifically, the communities of SOB, mainly including Thioalkalivibrio, Burkholderia, Paracoccus, Bradyrhizobium, and Hydrogenophaga genera, were remarkably influenced by the levels of NH4+-N and salinity. Yet, for SRB communities, including Desulfurivibrio, Candidatus Electrothrix, Desulfonatronospira, Desulfonatronum, Desulfonatronovibrio, Desulfonatronobacter and so on, the most significant determinants were salinity and NO3--N. Besides, Rhodoplanes played a significant role in the interaction between SOB and SRB. From our results, the knowledge regarding the community structures of SOB and SRB in extremely haloalkaline environment was extended.
Together Apart: Increased Crowd Heterogeneity Influences Crowd Dynamics and Interpersonal Distance at Bottlenecks
Authors: Geoerg Paul , Schumann Jette , Boltes Maik , Kinateder Max 
Published: December 2021

Abstract
Despite considerable research efforts, most controlled empirical studies on crowd movement usually rely on homogeneous crowds, i.e., research participants are typically young adults without disabilities. Consequently, little is known about pedestrian movement in more diverse and heterogeneous crowd conditions, e.g., when persons with reduced mobility are present. This gap may be particularly relevant at bottlenecks, along the path of a moving crowd that limit the capacity of pedestrian flow. Here, we present results from 12 studies in which participants (total N = 252) with and without visible disabilities moved together in a crowd. In each study, groups of participants walked together in a hallway with a bottleneck at the end. The point of speed adoption, distances between neighbours, and behavioural activities were analysed. We found (1) that participants with disabilities reduced their speed further away from the bottleneck than participants without disabilities; (2) participants without disabilities stayed closer to neighbors with disabilities than to neighbors without disabilities; and (3) participants interacted and communicated with each other to organise in front of the bottleneck. These results underline the importance of studying representative and heterogeneous samples in crowd dynamics. We also argue that more interdisciplinary research is needed to better understand the dynamics of interactions between neighbors in a crowd. A more nuanced understanding of pedestrian dynamics holds the promise of improving the validity of simulation tools such as movement and evacuation models.
GPER Activation Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome Sex-Dependently and Inhibits Alveolar Macrophage Activation
Authors: Yang Cui , Cong Zhukai , Zhao Feng , Shen Ziyuan , Zhu Xi 
Published: December 2021

Abstract
Background: Acute respiratory distress syndrome (ARDS), a common and critical disease, is clinically characterized by uncontrolled inflammation and alveolar-capillary barrier disruption. Estrogen can reportedly alleviate ARDS caused by numerous insults in mice. Moreover, the estradiol receptors α, not β,participated in E2-induced attenuation of ARDS. But the role of another estradiol receptor, G protein-coupled estradiol receptor 1 (GPER1) in ARDS are not undertood. This study is aimed to investigate the effect of GPER activation on LPS-induced ARDS in mice.Methods: Female mice were randomly subjected to bilateral ovarectomy (OVX) or sham surgery two weeks before lung injury. The GPER-selective agonist G1 or vehicle were intraperitoneally injected 0.5 h before intratracheal administration of LPS or phosphate-buffered saline in male and female mice. After 24 h, mice were sacrificed to collect blood, bronchoalveolar lavage fluid (BALF), and lung tissue. Histological injury and inflammatory cell infiltration in lung tissue, as well as cytokine and protein concentrations in BALF were determined. In vitro experiments were also performed on alveolar macrophages (MH-S cells) to investigate the effect of GPER activation on LPS-induced inflammatory responses.Results: Activation of GPER by G1 administration significantly ameliorated lung pathological damage, attenuated alveolar capillary barrier destruction, inhibited recruitment of inflammatory cells into alveoli, and decreased concentrations of the pro-inflammatory factors tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in BALF of LPS-administered male and OVX female mice, but not intact female mice. In vitro experiments demonstrated that G1 pretreatment significantly inhibited LPS-mediated increases of TNF-α, IL-6, and MIP2 in a dose-dependent manner.Conclusions: These results demonstrated that GPER activation attenuated lung injury of male and OVX female mice by inhibiting the inflammatory response of alveolar macrophages.
Decomposition of Fine Roots and Aboveground Agroforestry Litter as Plant-soil Feedback After Volcanic Ash Deposition
Authors: Purnamasari Eka , Noordwijk Meine van , Maulana Rizky , Saputra Danny , Sari Rika Ratna , Hairiah Kurniatun 
Published: December 2021

Abstract
Background and PurposeAbove- and belowground organic inputs feed decomposer communities in the soil enhancing soil organic matter (Corg) formation, depending on the vegetation, soil, contextual factors and human management of (agro)ecosystems. Plant-soil feedback in volcanic ash rapidly increases Corg during transformation to Andisols. We quantified fine root turnover in agroforestry systems, including the ash-adapted native tree Parasponia rigida, as part of the C accumulation process. MethodsFine root (<2 mm) decomposition was quantified with a total of 1440 litterbag samples, testing the effects of six tree species (Coffea canephora, Persea americana, Durio zibethinus, Gliricidia sepium, Falcataria moluccana and Parasponia rigida), three distances to the nearest coffee trees, two seasons (rainy and dry), two sites (with and without recent ash deposits), four time intervals (2, 4, 6 and 8 weeks) and five replicates. Soil temperature around the litterbags was used to derive equivalent decomposition rates at 20oC. The ratio of lignin plus phenolics over nitrogen was used as main litter quality indicator.ResultsDecomposition of fine tree roots was up to three times faster than that of aboveground litter with the same quality index measured in the same habitat. Root decomposition was slower in topsoils with recent volcanic ash, with a mean residence time extended by, on average, two weeks. Decomposition of roots of the ash-adapted native tree Parasponia rigida was especially rapid. ConclusionsFine root turnover contributes to the Corg accumulation that turns low-C volcanic ash into high-carbon andic soil and has relatively short necromass residence times.
Association of Circulating Circular RNAs (mmu-015947, hg38-0008980, and DLGAP4) in Diagnosis, Diseases Severity, and Prognosis of Ischemic Stroke
Authors: Zeraatiannejad Mastaneh , Bayat Mahnaz , Tabrizi Reza , Borhani-Haghighi Afshin , Mokhtari Mohammad Javad 
Published: December 2021

Abstract
Backgrounds Quickly diagnosing ischemic stroke (IS) is a critical issue in clinical studies, as it allows more effective therapy and stops the progression of IS. The blood level of CircRNAs after stroke may act as a rapid diagnostic marker.Methods and Results In this study, the blood level of circRNAs was evaluated using a real-time PCR. We used logistic and linear regression analysis to evaluate the potential of circRNAs levels with the risk of IS. Circ-mmu-015947 was up-regulated in patients. Its expression also showed a good value in predicting IS risk, and a significant diagnostic value. CircDLGAP4 was decreased in patients compared with controls and logistic regression showed its expression negatively associated with IS risk. The expression level of hg38 was reduced significantly in patients with small vessel disease (SVD) and the linear regression analysis showed a negative relationship between hg38 expression with SVD subtype. Circhg38 expression relative to controls showed a significant association with IS risk. Conclusion Taken together, circulating circ-mmu-015947 may serve as a novel biomarker for IS, and we found a significant decrease in the level of hg38-0008980 after IS it may act as a novel circRNA in IS pathophysiology with a positive correlation with stroke severity.
Roots With Larger Specific Root Length and C: N Ratio Sustain More Complex Nematode Community
Authors: Zhang Jingru , Hu Zhengkun , Zhang Chongzhe , Tao Yiheng , Chen Xiaoyun , Griffiths Bryan , Liu Manqiang 
Published: December 2021

Abstract
Aims Roots bridge above and belowground systems, and play a pivotal role in structuring root-associated organisms via influencing food resources and habitat conditions. Most studies focused on the relationships between plant identity and root-associated organisms, however, little is known about how root traits affect nematode communities within the rhizosphere. Methods We investigated the relationships between root traits of four plant species and nematode diversity, community structure and trophic complexity in an ex-arable field. Results While the relative abundance of herbivorous nematodes was negatively associated with specific root length (SRL), specific root area (SRA), root length density (RLD) and root C: N ratio, free-living nematodes were positively affected by these traits, implying a multifaceted effect of root traits on root-associated organisms. Importantly, we found that finer root systems promoted the complexity of the nematode community, by increasing the relative abundance of high trophic-level nematodes (i.e., omnivores and predators) and enhancing nematode diversity. Conclusion Our findings suggest that root traits could be reliable indicators of soil community structure and interactions, and provide new insights into soil biodiversity and functional maintenance.
Removal of Silica in Wastes With Methyl Cellulose Composite Membranes
Authors: Dağıdır Demet , Acaralı Nil 
Published: December 2021

Abstract
In this study, experiments were carried out for composite membrane synthesis with m-phenylenediamine (MPD), hydroxyethyl methacrylate (HEMA) and methyl cellulose (MS) by changing process parameters (methyl cellulose ratio, synthesis temperature, stirring time, oven temperature). Taguchi Method, an optimization method for production, was applied to 4 levels 4 parameters. The silica solution was passed through the produced composite membrane, and the filtering property of the membrane for different periods was examined. Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscope (SEM), X-Ray Diffraction (XRD) were used for characterization of composite membranes. Shore A test was performed to determine the mechanical strength of composite membranes. The amount of silica in membranes obtained because of the silica treatment was determined by Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) analysis. As a result, it was seen that the composite membranes produced could be evaluated in the treatment of wastewater containing silica.
Targeting the Tumor Immune Microenvironment Could Become a Potential Therapeutic Modality for Invasive Pituitary Adenoma.
Authors: Yang Zuocheng , Tian Xuemei , Wang Chen , Yao Kun , Yang Yakun , Zhang Linpeng , Liu Ning , Yan Changxiang , Qi Xueling , Han Song 
Published: December 2021

Abstract
Objective: The study aimed to explore the relationship between the invasiveness and immune cell infiltration in pituitary adenoma (PA) and provide the basis for immuno-targeting therapies.Methods: One hundred three patients who underwent surgery at a single institution were retrospectively identified. The infiltration of macrophages and T lymphocytes was quantitatively assessed in PA.Results: The number of CD68+ macrophages was positively correlated with Knosp (P=0.003) and MMP-9 grades (P=0.00). The infiltration of CD163+ macrophages differed among Knosp (P=0.022) and MMP-9 grades (P=0.04). CD8+ tumor-infiltrating lymphocytes (TILs) were also positively associated with Knosp (P=0.002) and MMP-9 grades (P=0.01). Interestingly, MGMT expression was positively correlated with MMP-9 staining extent (P=0.000). The quantity of CD8+ TILs (P= 0.016), CD68+ macrophages (P=0.000) and CD163+ macrophages (P=0.043) were negatively associated with MGMT expression levels. The number of CD68+ macrophages in the PD-L1 negative group was significantly more than in the PD-L1 positive group (P=0.01). The rate of PD-L1 positivity had positive correlations with the Ki-67 index (P=0.046) and p53 expression (P =0.029). Conclusion: Targeted therapy for macrophages and CD8+ TILs could be a helpful treatment in the future for invasive PA. Temozolomide (TMZ) may have better effects on the treatment of PA infiltrating more immune cells. Anti-PD-L1 therapy may better respond to PA with higher Ki-67, p53 expression and more infiltrating CD68+ macrophages. Multiple treatment modalities, especially combined immunotherapy, or immunotherapy with TMZ combination, could become a novel therapeutic strategy for invasive PA.
RBM24 Mediates Lymph Node Metastasis and Epithelial-Mesenchymal-Transition in Human Hypopharyngeal Squamous Cell Carcinoma Via Regulating Twist1
Authors: Liu Yuhong , Lu Tao , Pan Min , Yu Dan , Li Yanshi , Hu Guohua 
Published: December 2021

Abstract
Background: Hypopharyngeal squamous cell carcinoma (HSCC) has the worst prognosis among head and neck tumours, and Lymph node (LN) metastasis mainly accounts for the poor prognosis. RBM24 (RNA Binding Motif Protein 24) regulates target RNA as an RNA binding protein involved in several cancers. However, its role in HSCC remains completely unknown. Here we attempt to explore the effects of RBM24 on HSCC. Methods: RNA sequencing was conducted to find the differentially expressed genes in tumour tissues from HSCC patients with LN metastasis and without LN metastasis in our previous study. Expression of RBM24 in HSCC tissues was analyzed by qRT-PCR, western blot and immunohistochemistry. Cell proliferation was tested by CCK8 assay as well as Colony formation analysis. Cell migration and invasion capacity were estimated by transwell assay. The wound healing assay was also carried out to evaluate the motility of FaDu cells. QRT-PCR, western blot and immunofluorescence assays were conducted to detect the process of EMT. A popliteal lymph node metastasis model was constructed to explore the effect of RBM24 on HSCC in vivo.Results: RBM24 was remarkably down-regulated in HSCC patients with LN metastasis, and low expression of RBM24 was inextricably linked to the poor prognosis. Knockdown of RBM24 facilitated the proliferation, migration and invasion of RBM24, whereas overexpression of RBM24 showed the opposite effects and suppressed the epithelial-mesenchymal-transition (EMT) process. Overexpression of Twist1 could reverse the inhibitory effects of RBM24 on motility and invasion of FaDu cells. The inhibitory effects of RBM24 on tumour growth and lymphatic metastasis in HSCC were demonstrated by the in vivo experiment as well.Conclusions: These results indicated RBM24 was a suppressor gene and might inhibit EMT and LN metastasis in HSCC via regulating Twist1.
Gastric Cancer and Associated Pathogens: Is There Any Association in Moroccan Region?
Authors: Boukhris Samia Alaoui , khadir Mounia El , Karim Safae , Souho Tiatou , Benajah Dafr-Allah , Ibrahimi Sidi Adil , Chbani Laila , Abkari Mohamed El , Bennani Bahia 
Published: December 2021

Abstract

Purpose: Helicobacter pylori, Epstein-Barr virus and human papillomavirus are three pathogens associated with various human cancers. This study aimed to investigate the role of these pathogens in gastric cancer in Moroccan population Methods: For this, a retrospective study has been conducted on participants attending the gastroenterology department of Hassan II University Hospital of Fez. A total of 279 participants were enrolled. H. pylori, EBV and HPV were detected and genotyped by PCR.Results: A significant association has been established between H. pylori, EBV and gastric cancer. 93.4% and 43.3% of gastric cancer cases are related to H. pylori and EBV respectively (p≤0.01). H. pylori-EBV co-infection is responsible of 31.6% of gastric cancer cases (p<0.01). Correlation between pathogens genotypes and gastric cancer shows 55.6% of GC EBV positives are carrying the 30bp deletion in LMP1gene, while 16% of gastric cancers cases are carrying high-risk genotypes of HPV (p=0.21). Conclusion: The obtained results highlight the possible role of co-infection in gastric cancer development.
The Cyclical Sine Model Explanation for Climate Change
Authors: Nierode Dale Erwin 
Published: December 2021

Abstract
This paper will show that the global warming/climate change underway on Earth today is a totally natural occurrence with solid scientific and historical support. The Earth is currently in the upswing part of its normal temperature cycle. Very warm (Medieval Warming) and very cold (Little Ice Age) cycles have been historically documented on Earth for at least the last 3,000 years. This cyclicity has a repeated period of approximately every 1,500 years [1]. The explanation for the Earth’s temperature increases since 1850 is captured in a mathematical model called the Cyclical Sine Model. This model fits past climate cycles, measured temperatures since 1850, and correlates closely with the thousand year cyclicity of solar activity from 14C/12C ratio studies [2], and Bond [3] Atlantic drift ice cycles. This model also agrees with sunspot history, the Atlantic Multidecadal Oscillation, and the Pacific Decadal Oscillation. In addition, this model quantitively explains the time span 1945-1975 when an impending ice age was feared [4]. Earth temperatures are controlled by three solar cycles of approximately 1,000, 70, and 11 years. The Cyclical Sine Model is the best explanation for the Earth’s recent temperature increases.