bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Benefits of Using Garlic Oil and Its Active Constituent, Dially Disulphide, in Combination With Carvedilol in Ameliorating Isoprenaline-Induced Cardiac Damage in Rats
Authors: Asdaq Syed Mohammed Basheeruddin , Challa Obulesu , Alamri Abdulhakeem S. , Alsanie Walaa F. , Alhomrani Majid , Asad Mohammed 
Published: September 2021

Garlic oil and its primary component, diallyl disulphide (DADS), were tested in rats with isoprenaline (ISO) induced myocardial infarction for cardioprotective benefits when combined with carvedilol. Garlic oil (GO) was administered to rats (Sprague-dawley strain) at two doses of 50 and 100 mg/kg body weight, whereas DADS was given in two doses of 4.47 and 8.94 mg/kg, respectively. The animals were given oral doses of garlic oil and DADS on alternate days for 3 weeks, either alone or in combination with carvedilol (2 mg/kg). Cardiac injury was done by administering two doses of isoprenaline (150 mg/kg, sc) to all treated groups except the first, which served as a control. Biomarkers of cardiac injury and histological investigations were studied for their potential in reducing ISO-induced myocardial damage. Animals pretreated with GO, DADS, and carvedilol had significantly (p &lt; 0.01) lowered heart weight and heart to body weight ratio. In rats treated with carvedilol plus high dosages of garlic oil (100 mg/kg, p.o) and DADS (8.94 mg/kg, p.o) compared to the ISO control and carvedilol group, the activities of SOD and Catalase were enhanced in cardiac tissue homogenate. When compared to ISO control and carvedilol group, the activities of LDH and CK-MB were elevated in heart tissue homogenate with a simultaneous reduction in their serum levels in animals treated with a combination of carvedilol with high doses of garlic oil (100 mg/kg, p.o) and DADS (8.94 mg/kg, p.o). Overall, combining garlic oil or DADS with carvedilol improved the cardioprotective effect of carvedilol and protected rats from ISO-induced myocardial infarction. However, more research is needed to establish the mechanism of garlic oil and DADS interaction with carvedilol.
Relationship Between Medical Students’ Empathy and Occupation Expectation: Mediating Roles of Resilience and Subjective Well-Being
Authors: Wu Wenzhi , Qi Qiqi , Cao Xin , Li Shujun , Guo Zhichao , Yu Lei , Ma Xiao , Liu Yilin , Liu Zijun , You Xu , Chen Yatang , Long Qing , Teng Zhaowei , Zeng Yong 
Published: September 2021

Background: The occupation expectation of medical students can predict the possibility of their future employment in the medical industry, and empathy is the special ability of medical students in their study and career, which affects the development of their occupation expectation.Objective: To explore the relationship between resilience and subjective well-being between medical students’ empathy and occupation expectation and their internal mechanisms.Design: Data were collected from October 2020 to March 2021 using a paper questionnaire survey.Subjective: 586 medical students at a key medical university in Yunnan Province were invited to complete the survey.Main Measures: The Basic Empathy Scale, Connor-Davidson Resilience Scale, Subjective Well-Being Questionnaire, and Occupation Expectation Scale.Key Results: The empathy is intended to affect the occupation expectation of medical students through four paths. The direct path effect value is 0.073 (95% CI: 0.007∼0.217), the indirect path 1 effect value is 0.078 (95% CI: 0.022∼0.134), indirect path 2 effect value is 0.010 (95% CI: 0.005∼0.022), indirect path 3 effect value is 0.022 (95% CI: 0.0604∼0.039), all the confidence intervals do not contain 0, and the mediated effect ratio is 60.109%.Conclusion: Empathy has an impact on occupation expectation of medical students through the sequential mediating effects of resilience and subjective well-being. Medical colleges should fully consider the role of protective factors when cultivating and enhancing the occupation expectation of clinical medical students. Strengthening the intervention of emotional factors (empathy), self-regulating ability (psychological toughness) and cognitive factors (subjective well-being) is an important way to effectively establish professional values, improve occupation expectation of medical students and reduce the turnover rate of medical students.
The Association of Muscle Dysmorphia, Social Physique Anxiety, and Body Checking Behavior in Male College Students With Weight Exercise
Authors: Zheng Yu , Zhang LiFeng , Shao Ping , Guo XueYing 
Published: September 2021

Objectives: To investigate the association between muscle dysmorphia (MD), social physique anxiety, and body-checking behavior in male college students with weight exercise, and to reveal the association between them.Methods: A total of 492 male college students with weight exercise from 18 Fitness Clubs or bodybuilding centers in Chengdu, China, participated in this study.Results: First, the social physique anxiety scores, body checking frequency, and weight exercise behavior (i.e., frequency, time, and intensity) in male college students with MD were significantly higher than those without MD; it indicated that the higher the exercise frequency they had, the longer the exercise time they cost, and the higher exercise intensity carried out, and the higher the social physique anxiety scores tended to be, the higher the frequency of body checking on “global muscles,” “chest and shoulder muscles,” “comparison with others” and “posture measurement” they did. Second, the mediating effect of the social physique anxiety on MD and body checking was established in the “MD → global muscle checking,” “MD → chest and shoulder muscle checking,” “MD → comparison with others,” and “muscle dysmorphia → posture measurement.”Conclusion: Male college students with MD not only have a higher social physique anxiety, but also a higher frequency of body-checking behavior than the ordinary individuals. Social physique anxiety is one of the important mediating factors to those with MD which affects the body-checking behavior.
Time Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017
Authors: He Jun , Ouyang Feiyun , Qiu Dan , Li Ling , Li Yilu , Xiao Shuiyuan 
Published: September 2021

Background: High suicide rate in the elderly is an important global public health problem but has not received the attention it deserves. This study aimed to examine time trends of suicide mortality for people aged 70 years and over by sex, age, and location from 1990 to 2017, and to provide predictions up to 2030.Methods: Using data from the Global Burden of Disease study 2017, we presented elderly suicide mortality changes and compared the patterns for the elderly with that for all ages. We estimated associations between socio-demographic index (SDI) and suicide mortality rates using a restricted cubic spline smoother, and predicted suicide mortality rates up to 2030.Results: In 2017, 118,813 people aged 70 years and over died from suicide, indicating a mortality rate of 27.5 per 100,000, with the highest rates in Eastern Sub-Saharan Africa, Western Sub-Saharan Africa, and Central Sub-Saharan Africa, and for countries and territories, the highest were in South Korea, Zimbabwe, Lesotho, Mozambique, and Senegal. Between 1990 and 2017, suicide mortality rate for the elderly aged 70 years and over decreased globally (percentage change −29.1%), and the largest decreases occurred in East Asia, Southern Latin America, and Western Europe. Nationally, the largest decrease was found in Chile, followed by Czech Republic, Hungary, Turkey, and Philippines. For most countries, the elderly mortality rate was higher than the age-standardized rate, with the largest percentage differences in China and countries in Sub-Saharan Africa. The elderly suicide mortality rate decreased as SDI increased, except for a slight rebound at mid to high SDI. According to projections, 10 out of 195 countries were expected to meet the SDGs indicator of a third reduction by 2030.Conclusions: Variability in suicide mortality rates for the elderly aged 70 years and over by sex, age, region, country, and SDI can guide preventive policies, but causes of the variability need further study. Comprehensive strategies should be adopted to reduce suicide rates and close the gap to the 2030 SDGs.
Gender Discrepancies in SARS-CoV-2 Pandemic Related Beliefs, Attitudes, and Practices
Authors: Pflugeisen Bethann Mangel , Mou Jin 
Published: September 2021

Objectives: International studies suggest that males may be less likely to adhere to SARS-CoV-2 transmission mitigation efforts than females. However, there is a paucity of research in this field in the United States. The primary aim of this study was to explore the relationship of binary gender identity (female/male) with beliefs, attitudes, and pandemic-related practices in the early stages of the pandemic.Methods: This study is based on a cross-sectional, voluntary response survey. Patients who were tested for SARS-CoV-2 between March 5 and June 7, 2020 were invited to participate. All patients were tested within a large community healthcare system that serves patients through eight hospitals and hundreds of clinics across Washington State. Bivariate associations between gender and various demographics were tested using Chi-squared and Student's t-tests. We examined associations between gender and pandemic-related beliefs, attitudes, and practices using multivariable logistic regression, accounting for potential confounding factors.Results: Females were more likely than males to agree that they (aOR = 1.51, 95% CI 1.14–2.00) or their families (aOR = 1.75, 95% CI 1.31–2.33) were threatened by SARS-CoV-2, or that their own behavior could impact transmission (aOR = 2.17, 95% CI 1.49–3.15). Similarly, females were more likely to agree that social distancing (aOR = 1.72, 95% CI 1.19–2.46), handwashing (aOR = 3.27, 95% CI 2.06–5.21), and masking (aOR = 1.41, 95% CI 1.02–1.94) were necessary to slow SARS-CoV-2 spread. Females were significantly less likely to visit outside of their social distancing circle (aOR = 0.62, 95% CI 0.47–0.81), but among those who did, practices of social distancing (aOR = 1.41, 95% CI 0.89–2.23), remaining outdoors (aOR = 0.89, 95% CI 0.56–1.40), and masking (aOR = 1.19, 95% CI 0.74–1.93) were comparable to males, while females practiced handwashing more than males (aOR = 2.11, 95% CI 1.33–3.34).Conclusions: Our study suggests that gender disparate beliefs, attitudes, and practices existed in the early stages of the SARS-CoV-2 pandemic. Efforts should be tailored to encourage males to engage with mitigation efforts in ongoing pandemic-related public health campaigns.
The Clinical Value of Pulmonary Rehabilitation in Reducing Postoperative Complications and Mortality of Lung Cancer Resection: A Systematic Review and Meta-Analysis
Authors: Mao Xiaowei , Ni Yiqian , Niu Yanjie , Jiang Liyan 
Published: September 2021

Background: Pulmonary rehabilitation is one meaningful way of improving exercise tolerance and pulmonary function. Thus, it may reduce the postoperative complications and mortality of pulmonary resection. Hence, we refreshed the data and conducted this systemic analysis.Method: We searched Pubmed, Web of Science, and EMBASE using “lung OR pulmonary” AND “operation OR resection OR surgery” AND “rehabilitation or exercise.” The cut-off date was September 30, 2020. The publications were filtrated, and data were extracted from all selected studies by two reviewers. Review Manger 5.1 and the fixed or random regression model were used for calculating the pooled odds ratio (OR).Result: Finally, 13 publications were enrolled in this study. Among them, five publications reported mortality, nine reported postoperative complications, and seven reported postoperative pulmonary complications. The pooled OR of mortality was 1.32 [95% confidence interval (CI): 0.54–3.23] for the pulmonary rehabilitation group, the pooled OR of postoperative complications was 0.62 (95% CI: 0.49–0.79) for the pulmonary rehabilitation group, and the pooled OR of postoperative pulmonary complications was 0.39 (95% CI: 0.27–0.56) for the pulmonary rehabilitation group. Subgroup analysis revealed the perioperative pulmonary rehabilitation was the most important part.Conclusion: Pulmonary rehabilitation may not affect the mortality of pulmonary resection patients, however, it could decrease the number of postoperative complications, especially pulmonary complications. Perioperative pulmonary rehabilitation was the most important part of the program.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms
Authors: Truong Duong Thi Quy , Hounmanou Yaovi Mahuton Gildas , Dang Son Thi Thanh , Olsen John Elmerdahl , Truong Giang Thi Huong , Tran Nhat Thi , Scheutz Flemming , Dalsgaard Anders 
Published: September 2021

We analyzed and compared genomes of Extended Spectrum Beta-Lactamase (ESBL)-producing Escherichia coli from pigs and pig farm workers at 116 farms in Vietnam. Analyses revealed the presence of blaCTX-M-55, blaCTX-M-27, blaCTX-M-15, blaCTX-M-14, blaCTX-M-3, blaCTX-M-65, blaCTX-M-24, blaDHA-1, and blaCMY2 in both hosts. Most strains from pigs contained quinolones (qnr) and colistin resistance genes (mcr-1 and mcr-3). Isolates predominantly harbored more than one plasmid replicon and some harbored plasmid replicons on the same contigs as the ESBL genes. Five strains from farm workers of ST38 (2), ST69 (1), and ST1722 (2) were classified as either uropathogenic E. coli (UPECHM)/extraintestinal pathogenic E. coli (ExPECJJ) or UPECHM, and the remaining were genetically distinct commensals. A high heterogeneity was found among the ESBL-producing E. coli from pigs and workers, with most isolates belonging to unrelated phylogroups, serogroups, and sequence types with >4046 Single-Nucleotide Polymorphisms-(SNPs). In comparing the genomes of pig isolates to those from humans, it appeared that ESBL-producing E. coli in workers did not predominantly originate from pigs but were rather host-specific. Nevertheless, the occurrence of ESBL-producing E. coli carrying plasmid-mediated colistin and quinolone resistance genes in pigs could represent a potential source for horizontal transmission to humans through food rather than direct contact.
Validation and Concordance Analysis of a New Lateral Flow Assay for Detection of Histoplasma Antigen in Urine
Authors: Cáceres Diego H. , Gómez Beatriz L. , Tobón Ángela M. , Minderman Melissa , Bridges Nicole , Chiller Tom , Lindsley Mark D. 
Published: September 2021

Histoplasmosis is a major cause of mortality in people living with HIV (PLHIV). Rapid methods to diagnose Histoplasma capsulatum disease could dramatically decrease the time to initiate treatment, resulting in reduced mortality. The aim of this study was to validate a MiraVista® Diagnostics (MVD) Histoplasma urine antigen lateral flow assay (MVD LFA) for the detection of H. capsulatum antigen (Ag) in urine and compare this LFA against the MVista® Histoplasma Ag quantitative enzyme immunoassays (MVD EIA). We assessed the MVD LFA using a standardized reference panel of urine specimens from Colombia. We tested 100 urine specimens, 26 from PLHIV diagnosed with histoplasmosis, 42 from PLHIV with other infectious diseases, and 32 from non-HIV infected persons without histoplasmosis. Sensitivity and specificity of the MVD LFA was 96%, compared with 96% sensitivity and 77% specificity of the MVD EIA. Concordance analysis between MVD LFA and the MVD EIA displayed an 84% agreement, and a Kappa of 0.656. The MVD LFA evaluated in this study has several advantages, including a turnaround time for results of approximately 40 min, no need for complex laboratory infrastructure or highly trained laboratory personnel, use of urine specimens, and ease of performing.
EMOTIONAL DEPENDENCE IN ROMANTIC RELATIONSHIPS: THE ROLE OF ADVERSE CHILDREN’S EXPERIENCE AND EARLY DYSFUNCTION SCHEMES
Authors: Shyroka A. , Brukh I. 
Published: September 2021

Emotional dependency is a persistent pattern of unsatisfied emotional needs, that the individual tries to fulfill in close intimate relationship in particular romantic relationship. Adverse childhood experiences (ACEs) are often identified as a cause of emotional dependency. However, there is plenty of evidence that many psychosocial problems are more strongly associated with early maladaptive schemas (EMS), than directly with ACEs. ACEs and EMS both can have effect on emotional dependency. Such assumption has strong theoretical reasoning, but there is still lack of empirical evidence about the exact role ACEs and EMS can play in emotional dependency. The present study examined early maladaptive schemas as mediators of the adverse childhood experiences – emotional dependency in romantic relationship.
The study has cross-sectional design. Questionnaires completed by 128 individuals (78% females) (Mage=26; SD=9), who currently or in the past were involved in romantic relationship. There were assessed 10 types of childhood trauma (The Adverse Childhood Experiences Questionnaire), early maladaptive schemas (Young Schema Questionnaire-Short Form) and emotional dependency (Emotional Dependency Questionnaire). The mediation role of EMS was tested by Baron and Kenny (1986) analysis strategy using hierarchical multiple regression procedures.
The findings showed that ACEs didn’t predict, but such EMS as abandonment / instability, mistrust / abuse and failure to achieve did predict emotional dependency in romantic relations (R2=0,44). The experience of emotional neglect mildly predicted schema of mistrust / abuse (R2=0,16).
Such results discussed in the context of previous research, limitations that restricted the study’s conclusions and future research recommendation.
COMPARATIVE ANALYSIS OF COMMUNICATION MOTIVES OF PRESCHOOLERS’ WITH VARIOUS DEGREES OF EMOTIONAL ADMIRATION OF JOINT ACTIVITY
Authors: Yudina N. 
Published: September 2021

The article presents the results of theoretical and empirical research of psychological peculiarities of communication motivation of preschoolers who have different degrees of emotional admiration of joint activity. As a result of theoretical analysis, it was found that the most common reason for children to choose a communication partner is the attractiveness of another person as a personality due to the moral, business or physical qualities, a manifestation of sympathy, love to this person, i.e. emotional attitude. At the same time, the need for a more detailed practical study of the problem was confirmed, because the issue of communication motivation in preschool age, in particular, the influence of the degree of emotional admiration of joint activity on this process, remains insufficiently resolved.
The data of an empirical study of the peculiarities of communication motives of preschool children with different degrees of emotional admiration of joint activity showed that the higher the degree of emotional interest of preschoolers for joint activity is, the higher the degree of development of communication motives they have. Parameters such as the subjective significance of a peer for a child, which is manifested in the general admiration of others; peer orientation, i.e. the ability to concede, to help; ability to empathy, as well as the child’s choice (to help or not to help to his or her peers), the degree of emotional admiration of the activity and an indication of its expression (positive or negative); the nature of the child’s behavior, its emotional expression, speech, were used as the main indicators of interpersonal relationships.
It was proved that the degree of preschoolers’ emotional admiration of joint activity is largely correlated with the level of development of their ability to concede and the willingness to help. Thus, the motives of communication of the preschooler with other children differ depending on the degree of his or her emotional admiration of joint activity, because it was found that the higher the degree of emotional admiration of preschoolers is, the higher the level of development of the ability to concede and the willingness to help they have.
Comparative analysis of the results using direct lateral interbody spondilodesis and transforaminal lumbar interbody spondilodesis in patients with degenerative diseases of the lumbar spine
Authors: Bokov A. E. , Bulkin A. A. , Kalinina S. Y. , Leontev A. V. , Mlyavykh S. G. 
Published: September 2021

Introduction Various spondylodesis techniques are used in patients with degenerative diseases of the lumbar spine, but the benefits of these techniques have not been proven.Objective of the study was to assess the effect of the type of fusion on the incidence of implant instability and related revision surgeries.Material and Methods This monocentric prospective study included 133 patients with degenerative stenosis of the lumbar spine and confirmed instability of spinal motion segments. Patients underwent transforaminal lumbar interbody fusion (TLIF) with a single cage or direct lateral interbody fusion (DLIF) using standard-sized cages. The conventional open technique was used to supplement TLIF with pedicle screws while percutaneous screw placement was applied in patients treated with DLIF. The duration of follow-up was 18 months. Fisher's exact test was used to assess differences in the incidence of fixator instability based on MSCT and revision interventions. Logistic regression was used to assess the association between potential risk factors and complication rates.Results The use of DLIF detected by MSCT (32.9 vs 3.6%, p < 0.0001) resulted in a significant reduction in the incidence of screw instability and associated revision interventions (11.8 vs 0%, p = 0.0122). The results of logistic regression, taking into account factors such as bone density and the number of levels at which spondylodesis was performed, confirm the relationship between the reduced incidence of complications and the use of DLIF technology. Conclusion Using DLIF instead of TLIF in patients with degenerative stenosis at the lumbar spine level can lead to a significant reduction in the frequency of screw instability and associated revision surgeries.
Analysis of the influence parameters spine-pelvic balance on the risk of development degeneration and degenerative disease of adjacent segments after lumbar spine rigid fixation
Authors: Spiridonov A. V. , Pestryakov Yu. Ya. , Kalinin A. A. , Byvaltsev V. A. 
Published: September 2021

Introduction An increase in the load on adjacent segments causes changes in the parameters of the spinal-pelvic balance and, as a consequence, the development of the so-called biomechanical «stress». Such pressures are a key link in the pathogenesis of degeneration, and in the presence of clinical and neurological manifestations of the latter and adjacent segment degenerative disease (ASD/ASDd).Objective of this study was to assess the effect of the parameters of the spinal pelvic balance on the risk of developing ASD/ASDd after dorsal decompression-stabilizing interventions (DDSI).Material and Methods The study included medical records of patients who underwent DDSI for lumbar spine degenerative diseases. Clinical and instrumental parameters were assessed.Results Based on the inclusion criteria, 98 patients (48 with signs of ASD/ASDd and 50 without) were included in the study. The average postoperative follow-up period for the respondents was 46.6 ± 9.8 months. If PI/ LL parameters were <10 and the ratio of segmental and global lumbar lordosis (LIV-SI/LI-SI) was 50% or more, the incidence of ASD/ASDd was significantly lower in patients who underwent rigid lumbar stabilization surgery.Conclusion The values of PI/LL parameters and the ratio of segmental and global lumbar lordosis are obvious risk factors for the development of ASD/ASDd after rigid lumbar spine DDSI.