bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin attenuates morphine‐induced conditioned place preference in Wistar rats
Authors: Alshehri Fahad S. , Alghamdi Badrah S. , Hakami Alqassem Y. , Alshehri Abdullah A. , Althobaiti Yusuf S. 
Published: October 2021

AbstractPurposeMorphine is the predominantly used drug for postoperative and cancer pain management. However, the abuse potential of morphine is the primary disadvantage of using opioids in pain management. Melatonin is a neurohormone synthesized in the pineal gland and is involved in circadian rhythms in mammals, as well as other physiological functions. Melatonin provenly attenuates alcohol‐seeking and relapse behaviors in rats. Therefore, we aimed to investigate the involvement of the melatonergic system in attenuating morphine dependence.Materials and methodsMale Wistar rats were divided into three groups: control, morphine, and morphine + melatonin. Animals were habituated for 3 days, and the initial preference was evaluated. Following the initial preference, the control group received the vehicle and was placed for a 45‐min session in the assigned chamber every day, alternating between the two chambers, for 8 days. The morphine group received a morphine injection (5 mg/kg, IP) and was placed for a 45‐min session in the white chamber, for a total of four sessions. The morphine + melatonin group received the morphine injection (5 mg/kg, IP) for a total of four sessions over an 8‐day period. In the posttest session, the control and morphine groups received a vehicle injection 30 min before placement in the conditioned place preference (CPP). The morphine + melatonin group received a single injection of melatonin (50 mg/kg, IP) 30 min before the preference test.ResultsStatistical analysis revealed that repeated administration of morphine for four sessions produced a significant increase in the CPP score in the morphine group compared to the control group. However, a single melatonin injection administered 30 min before the posttest attenuated morphine‐seeking behavior and reduced morphine‐induced place preference.ConclusionThese findings provide novel evidence for the role of the melatonergic system as a potential target in modulating morphine‐seeking behavior.
Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
Authors: Nimitrungtawee Natthaphong , Inmutto Nakarin , Chattipakorn Siriporn C. , Chattipakorn Nipon 
Published: October 2021

AbstractHepatocellular carcinoma (HCC) is the sixth most common cancer with a high mortality rate. Early diagnosis and treatment before tumor progression into an advanced stage is ideal. The current diagnosis of HCC is mainly based on imaging modalities such as ultrasound, computed tomography, and magnetic resonance imaging. These methods have some limitations including diagnosis in the case of very small tumors with atypical imaging patterns. Extracellular vesicles (EVs) are nanosized vesicles which have been shown to act as an important vector for cell‐to‐cell communication. In the past decade, EVs have been investigated with regard to their roles in HCC formation. Since these EVs contain biomolecular cargo such as nucleic acid, lipids, and proteins, it has been proposed that they could be a potential source of tumor biomarkers and a vector for therapeutic cargo. In this review, reports on the roles of HCC‐derived EVs in tumorigenesis, and clinical investigations using circulating EVs as a biomarker for HCC and their potential diagnostic roles have been comprehensively summarized and discussed. In addition, findings from in vitro and in vivo reports investigating the potential roles of EVs as therapeutic interventions are also presented. These findings regarding the potential benefits of EVs will encourage further investigations and may allow us to devise novel strategies using EVs in the early diagnosis as well as for treatment of HCC in the future.
Factors influencing ‘burn‐out’ in newly qualified counsellors and psychotherapists: A cross‐cultural, critical review of the literature
Authors: Davies Siân M. , Sriskandarajah Shamini , Staneva Aleksandra S. , Boulton Helena C. M. , Roberts Chelsey , Shaw Shereen H. , Silverio Sergio A. 
Published: October 2021

AbstractMental health problems have been established as one of the leading causes of the global burden of disease. Approximately a quarter of all people worldwide will experience a mental disorder during their lifetime. With depression and anxiety becoming the leading causes of mental ill health globally, the numbers of people reporting mental health complaints are set to grow. The dramatic increase in reporting and diagnosis of mental health disorders has been in parallel to a decline in the ability to cope with mental health symptoms and a rise in the incidence of self‐harm and suicidal ideation. While mental health assessment and diagnoses are usually the responsibility of general practitioners (family doctors) or psychiatrists, the frontline provision of mental health care is often delegated to counsellors and psychotherapists. Publicly funded counselling and psychotherapy services vary across the globe, but are commonly under‐resourced and lacking in adequate funding. This may lead to insufficient clinical supervision and compressed time to complete continuing professional development, which are both vital for new counsellors and psychotherapists to feel confident in providing care, and to learn new skills. Newly qualified counsellors and psychotherapists may also experience emotional, physical, and mental exhaustion or ‘burn‐out’. This position paper aims to critically appraise available cross‐cultural literature on the experiences of ‘burn‐out’ by newly qualified counsellors and psychotherapists, globally. Finally, we make recommendations for how best to support the mental health and psychological well‐being of newly qualified practitioners.
Accurate cisAB typing is essential to ensure the safety of a transfusion: A case of a cisAB01 neurosurgery pediatric patient and family study
Authors: Zhang Yanan , Wang Nuochuan , Tian Yongji 
Published: October 2021

AbstractThe rare cisAB subgroups inherited from a single parent are characterized by the activities of dual A and B glycosyltransferases encoded by a gene on one chromosome. The serological complexity of cisAB challenges clinical blood transfusion practice because of misclassification in ABO grouping.
Leech therapy of nipple‐areolar complex (NAC) congestion in reduction mammoplasty: A case report
Authors: Vasei Narges , Jahangiri Katayoun 
Published: October 2021

AbstractLeech therapy is a safe, easy‐to‐use, cost‐effective traditional treatment to save reattached body parts and flaps in reconstructive plastic surgery especially in cases with blood circulatory problems.
Endoscopic‐assisted transantral‐endonasal approach to large dentigerous cyst of maxillary sinus
Authors: Sigdel Brihaspati , Sah Kusheswar , Kandel Dipendra , Karn Mitesh , Moran Andrew , Panta Ashirbad 
Published: October 2021

AbstractDentigerous cysts are seen in the maxillary canine and third molars. We report a case of dentigerous cysts invading the maxillary sinus, which was managed surgically by endoscopic‐assisted transantral and transnasal approach.
Possible HSP reactivation post‐COVID‐19 vaccination and booster
Authors: Kondo Makoto , Yamanaka Keiichi 
Published: October 2021

AbstractA 45‐year‐old woman with a history of Henoch‐Schönlein (HSP) purpura received COVID‐19 vaccination. The patient showed HSP reactivation after COVID‐19 vaccination and booster. In HSP, autoimmune memory of vasculitis persists and might be reactivated with COVID‐19 vaccination.
Efficient Automation Engineering of Modular Process Equipment Assemblies Using the Digital Twin
Authors: Rahm Julian , Theißen Manfred , Klose Anselm , Soemers Marcus , Temmen Heiner , Schäfer Christian , Urbas Leon 
Published: October 2021

AbstractModular process plants are a promising approach to accelerate the engineering of greenfield process plants. This is achieved by the combination of pre‐engineered process equipment assemblies (PEAs) with a standardized interface for the integration in process control systems, the module type package (MTP). This standardized interface can be integrated in the engineering process to further improve the potential. In this paper existing standards are used to generate aspects of the MTP. For this purpose, the engineering process of conventional plants is adapted for the engineering of PEAs. Therefore, similarities and potential of the described aspects have been analyzed regarding shared fundamental standards and characterized by their location in the asset life cycle. To describe the interconnections of the different standards, exemplary rules are proposed, which can be used for a transformation.
Functionalized ZIF‐90 for Gene‐mediated Chemotherapy to Ameliorate Multidrug Resistance in Breast Cancer Therapy
Authors: Gong Senyi , Shang Mengdi , Li Dawei , Cai Yanfei , Jin Jian , Yang Zhaoqi 
Published: October 2021

AbstractBreast cancer, the most common cancer, is a threat to women's health. A great challenge for breast cancer is the multidrug resistance (MDR) problem. P‐glycoprotein (P‐gp) is one of main reasons to induce MDR in the therapy of breast cancer. A novel nanosystem based on ZIF‐90 was developed for alleviating MDR and to improve the therapeutic efficacy. In this investigation, ZIF‐90 was used as a carrier to deliver two kinds of DNA molecular beacons (MBs) and Doxorubicin (Dox). The loop sequences of two kinds of MBs were designed to specifically hybridize with the mRNAs related to P‐gp (MDR1 gene and ETS1 gene, respectively), thereby directly inhibiting the expression of downstream proteins P‐gp. The results of confocal fluorescence imaging and qRT‐PCR analysis indicated that MB and Dox were delivered into cells and the mRNAs related to P‐gp were silenced. The MTT assay showed that the IC50 of nanosystem to the drug‐resistant breast cancer cells (34.78 μg/mL) was much lower than the IC50 of Dox to the same cells (152.7 μg/mL). These results distinctly confirmed that the problem of MDR has been ameliorated by our designed nanosystem. It is our hope that this investigation may provide a new treatment strategy for enhancing the therapeutic efficacy of chemotherapy for breast cancer.
Paget's disease of nipple with dermal invasion: A case report
Authors: Maharjan Rubina , Shrestha Suraj , Shakya Prafulla , Kharel Sanjeev , Shrestha Aagon Krishna , Singh Moushami 
Published: October 2021

AbstractBackgroundInvasive mammary Paget's disease (MPD) is an extremely rare eczematous eruption on the nipple and areola with an invasion of the dermis by Paget cells. This entity can often be misdiagnosed and overtreated for invasive carcinoma of the breast.CaseA 34‐year woman presented with a 2‐year history of right nipple eczema and right axillary lump for a month. Breast ultrasound revealed dilated intra‐nipple lactiferous duct and an enlarged right axillary lymph node. Histopathology from biopsy revealed MPD with ductal carcinoma in situ (DCIS) whereas final histopathology after right modified radical mastectomy revealed Invasive MPD with DCIS and axillary metastasis. She underwent adjuvant chemotherapy and is under hormonal therapy with complete remission for 18 months.ConclusionAwareness of invasive MPD is important to avoid misdiagnosis and probable radical treatment. Close follow‐up is warranted due to limited knowledge regarding treatment and prognosis of invasive MPD.
Solvation and Ion‐Pairing Effects of Choline Acetate Electrolyte in Protic and Aprotic Solvents Studied by NMR Titrations
Authors: Veroutis Emmanouil , Merz Steffen , Eichel Rüdiger‐A. , Granwehr Josef 
Published: October 2021

AbstractCholine‐based electrolytes have been proposed as environmentally friendly and low‐cost alternatives for secondary zinc air batteries. Choline acetate [Ch]+[OAc]− in protic (D2O) and aprotic (DMSO‐d6) solvents has been studied by means of concentration‐dependent 1H NMR, viscosity, and density measurements. The viscosities have been calculated on the basis of the Jones‐Dole equation and showed that the dominant contribution originates from short‐range ion‐solvent interactions. Site‐specific association affinities were assigned from NMR chemical shift titrations. In DMSO‐d6, the hydroxyl group of choline was found to have the smallest dissociation constant followed by the methyl group of acetate. The corresponding Gibbs energies at low concentration were found to be in agreement with a solvent‐separated ion pair (2SIP) configuration, whereas at concentrations above 300 mM, a solvent‐shared ion pair (SIP) configuration was assigned. For [Ch]+[OAc]− in D2O, association effects were found to be weaker, attributed to the high dielectric constant of the solvent. On time scales on the order of 100 ms, NMR linewidth perturbations indicated a change in the local rotational dynamics of the ions, attributed to short‐range cation‐solvent interactions and not to solvent viscosity. At 184 mM,
40 % of the cations in DMSO‐d6 and
10 % in D2O were found to exhibit short‐range interactions, as indicated by the linewidth perturbations. It was found that at about 300 mM, the ions in DMSO‐d6 exhibit a transition from free to collective translational dynamics on time scales on the order of 400 ms. In DMSO‐d6, both ions were found to be almost equally solvated, whereas in D2O solvation of acetate was stronger, as indicated by the obtained effective hydrodynamic radii. For [Ch]+[OAc]− in DMSO‐d6, the results suggest a solvent‐shared ion association with weak H‐bonding interactions for concentrations between 0.3–1 M. Overall, the extent of ion association in solvents such as DMSO is not expected to significantly limit charge transport and hinder the performance of choline‐based electrolytes.
Joint subcarrier and power allocation with proportional fairness in multicarrier nonorthogonal multiple access systems
Authors: Ding Hongwen , Li Li 
Published: October 2021

SummaryIn this paper, we investigate joint subcarrier and power allocation in multicarrier nonorthogonal multiple access (MC‐NOMA) systems aims to guarantee rate proportional fairness among all users. To this end, we adopt the sum logarithmic rate function as the objective and formulate a resource optimization problem which is a mixed‐integer nonlinear programming (MINLP) problem. Based on variable relaxation and replacement, we convert this problem into a convex optimization problem. On this basis, the expressions of joint subcarrier and power allocation solutions are obtained by using convex optimization theory and the Karush–Kuhn–Tucker (KKT) condition. However, power and subcarrier allocation solutions are highly coupled, and it is difficult to derive both solutions simultaneously. Fortunately, when the subcarrier allocation strategy is given, the optimal power allocation solution can be derived by solving the equations. Furthermore, we develop an iterative resource allocation algorithm to implement joint subcarrier and power allocation among users. Numerical results reveal that the proposed algorithm is effective in general multiuser and multicarrier scenarios, and a substantial performance improvement can be achieved by the proposed algorithm in contrast with the traditional orthogonal multiple access (OMA) schemes. In specific, the proposed algorithm achieves 63% and 59% gains in terms of utility and fairness performance, respectively.
Prevalence and genotype distribution of high‐risk human papillomavirus infection among women with cervical cytological abnormalities in Chongqing, China, 2014–2020
Authors: Luo Qinli , Lang Lin , Han Na , Liang Ling , Shen Lianjun , Zhang Haiyan 
Published: October 2021

AbstractBackgroundPersistent infection with high‐risk human papillomavirus (HR‐HPV) is the main leading cause of cervical precancerous lesions and cervical cancer. This study aims to explore the epidemiological characteristics of HR‐HPV genotypes and their correlation with the ThinPrep cytological test (TCT) results among women in Chongqing, in China.MethodsIn this retrospective study, cervical exfoliations of 14,548 women who visited Chongqing university cancer hospital were collected for detecting HR‐HPV genotypes and TCT.ResultsOverall, the rate of HR‐HPV infection was 14.26%. The three most common HR‐HPV genotypes are HPV52 (4.39%), HPV58 (2.21%), and HPV16 (1.94%). In this study, the positive rate of cervical TCT was 4.54%. Atypical squamous cells of undetermined significance (ASC‐US), atypical squamous cells that could not exclude high‐grade squamous intraepithelial lesion (ASU‐H), low‐grade squamous intraepithelial lesions (LSIL), high‐grade squamous intraepithelial lesions (HSIL), and atypical glandular cells of undetermined significance (AGC) were 2.99%, 0.20%, 0.92%, 0.29%, and 0.14%, respectively. Among the several types of cytological lesions, the HR‐HPV infection rates of ASC‐US, ASC‐H, LSIL, HSIL, and (AGC) were 24.82%, 41.38%, 64.18%, 95.24%, and 23.81%, respectively.ConclusionsHPV52, HPV 58, and HPV16 are the most common infection subtypes in Chongqing. When implementing HPV vaccine programs in Chongqing, HPV58 and HPV52 should be attached importance as HPV16 and HPV18.
Site fidelity and behavioral plasticity regulate an ungulate’s response to extreme disturbance
Authors: Kreling Samantha E.S. , Gaynor Kaitlyn M. , McInturff Alex , Calhoun Kendall L. , Brashares Justin S. 
Published: October 2021

AbstractWith rapid global change, the frequency and severity of extreme disturbance events are increasing worldwide. The ability of animal populations to survive these stochastic events depends on how individual animals respond to their altered environments, yet our understanding of the immediate and short‐term behavioral responses of animals to acute disturbances remains poor. We focused on animal behavioral responses to the environmental disturbance created by megafire. Specifically, we explored the effects of the 2018 Mendocino Complex Fire in northern California, USA, on the behavior and body condition of black‐tailed deer (Odocoileus hemionus columbianus). We predicted that deer would be displaced by the disturbance or experience high mortality post‐fire if they stayed in the burn area. We used data from GPS collars on 18 individual deer to quantify patterns of home range use, movement, and habitat selection before and after the fire. We assessed changes in body condition using images from a camera trap grid. The fire burned through half of the study area, facilitating a comparison between deer in burned and unburned areas. Despite a dramatic reduction in vegetation in burned areas, deer showed high site fidelity to pre‐fire home ranges, returning within hours of the fire. However, mean home range size doubled after the fire and corresponded to increased daily activity in a severely resource‐depleted environment. Within their home ranges, deer also selected strongly for patches of surviving vegetation and woodland habitat, as these areas provided forage and cover in an otherwise desolate landscape. Deer body condition significantly decreased after the fire, likely as a result of a reduction in forage within their home ranges, but all collared deer survived for the duration of the study. Understanding the ways in which large mammals respond to disturbances such as wildfire is increasingly important as the extent and severity of such events increases across the world. While many animals are adapted to disturbance regimes, species that exhibit high site fidelity or otherwise fixed behavioral strategies may struggle to cope with increased climate instability and associated extreme disturbance events.
Permafrost response to temperature rise in carbon and nutrient cycling: Effects from habitat‐specific conditions and factors of warming
Authors: Gao Wenlong , Sun Weimin , Xu Xingliang 
Published: October 2021

AbstractPermafrost is experiencing climate warming at a rate that is two times faster than the rest of the Earth's surface. However, it is still lack of a quantitative basis for predicting the functional stability of permafrost ecosystems in carbon (C) and nutrient cycling. We compiled the data of 708 observations from 89 air‐warming experiments in the Northern Hemisphere and characterized the general effects of temperature increase on permafrost C exchange and balance, biomass production, microbial biomass, soil nutrients, and vegetation N dynamics through a meta‐analysis. Also, an investigation was made on how responses might change with habitat‐specific (e.g., plant functional groups and soil moisture status) conditions and warming variables (e.g., warming phases, levels, and timing). The net ecosystem C exchange (NEE) was found to be downregulated by warming as a result of a stronger sensitivity to warming in respiration (15.6%) than in photosynthesis (6.2%). Vegetation usually responded to warming by investing more C to the belowground, as belowground biomass increased much more (30.1%) than aboveground biomass (2.9%). Warming had a minor effect on microbial biomass. Warming increased soil ammonium and nitrate concentrations. What's more, a synthesis of 70 observations from 11 herbs and 9 shrubs revealed a 2.5% decline of N in green leaves. Compared with herbs, shrubs had a stronger response to respiration and had a decline in green leaf N to a greater extent. Not only in dry condition did green leaf N decline with warming but also in wet conditions. Warming in nongrowing seasons would negatively affect soil water, C uptake, and biomass production during growing seasons. Permafrost C loss and vegetation N decline may increase with warming levels and timing. Overall, these findings suggest that besides a positive C cycling–climate feedback, there will be a negative feedback between permafrost nutrient cycling and climate warming.
Implantation of ventricular assist devices in hypertrophic cardiomyopathy with left ventricular systolic dysfunction
Authors: Yagi Nobuichiro , Seguchi Osamu , Mochizuki Hiroki , Kuroda Kensuke , Nakajima Seiko , Watanabe Takuya , Yanase Masanobu , Tadokoro Naoki , Fukushima Satsuki , Fujita Tomoyuki , Fukushima Norihide 
Published: October 2021

AbstractAimsThe outcomes of patients with hypertrophic cardiomyopathy with left ventricular systolic dysfunction (HCM‐LVSD) undergoing left ventricular assist device (LVAD) implantation remain unclear. We retrospectively evaluated the clinical impact of LVAD implantation on clinical outcomes, including haemodynamics and brain natriuretic peptide (BNP) levels, in patients with HCM‐LVSD, in comparison with those with dilated cardiomyopathy (DCM).Methods and resultsIn this retrospective, single‐centre, observational study conducted in Japan, the medical records of patients who underwent LVAD implantation in the National Cerebral and Cardiovascular Center between 2011 and 2020 were reviewed. We enrolled 96 patients with DCM (average age: 43.5 years; 73 men) and 24 patients with HCM‐LVSD (average age: 48.3 years; 16 men). The HCM‐LVSD group had smaller left ventricles with thicker ventricular walls than the DCM group, which became more prominent after LVAD implantation. Preoperatively, BNP values were comparable between both groups; however, 3 months post‐implantation, they were significantly higher in the HCM‐LVSD group. Pulmonary artery pulsatility index, right ventricular stroke work index, and cardiac index were lower, and right atrial pressure was higher, in the HCM‐LVSD group, suggesting subclinical impairment of right ventricular function. The HCM‐LVSD group demonstrated equivalent outcomes, including overall survival, cerebrovascular accidents, right ventricular failure, LVAD‐related infections, arrhythmia, and aortic insufficiency, post‐implantation.ConclusionsDespite a decreased right ventricular function with higher BNP values, patients with HCM‐LVSD and DCM showed comparable outcomes post‐LVAD implantation.