bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alternative splicing of ANLN synergistically contribute to the progression of head-neck squamous cell carcinoma
Authors: Guo Erliang , Mao xionghui , Guo Lunhua , An Changming , Zhang Cong , Song Kaibin , Wang Guohui , Duan Chunbin , Zhang Xiwei , Yang Xianguang , Yuan Zhennan , Sun Ji , Li Xiaomei , Yang Weiwei , Meng Hongxue , Miao Susheng 
Published: February 2021

Abstract
Objective

Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anillin (ANLN) has been identified as an actin-binding protein highly expressed in multiple cancers. However, the expression pattern and functional effects of ANLN in HNSCC remains to be unclear.
Methods

ANLN alternative splicing was assessed in HNSCC tissues and cell lines. We investigated the functional effects and related mechanisms of ANLN alternative splicing in HNSCC in vitro and in vivo.
Results

Our results showed that two ANLN alternative RNA splicing ANLN-201 and ANLN-210 were highly expressed in HNSCC tissues and cell lines. Knockout of ANLN led to inhibited proliferation, migration and invasion of SCC-9 cells. ANLN-201 mainly binded to Myc and thus played a role in promoting cell proliferation, migration and invasion of SCC-9. ANLN-210 was found to bind mainly to HNRNPC and secreting into the environment in the form of exosomes. Exosomal ANLN-210 promotes macrophage polarization via PTEN/PI3K/Akt signaling pathway, which in turn facilitated HNSCC tumor growth.
Conclusions

Variable alternative splicing of ANLN synergistically contribute to the progression of head-neck squamous cell carcinoma, which might offer new perspectives of HNSCC for treatment strategies.
Old Does Not Necessarily Mean Worse: Standard Stupp Regimen for Elderly Patients (≥ 70 years) with Newly Diagnosed Glioblastoma
Authors: Vaugier Loig , Ah-Thiane Loïc , Aumont Maud , Jouglar Emmanuel , Campone Mario , Colliard Camille , Doucet Ludovic , Frenel Jean-Sébastien , Gourmelon Carole , Robert Marie , Martin Stéphane-André , Riem Tanguy , Roualdes Vincent , Campion Loïc , Mervoyer Augustin 
Published: February 2021

Abstract
Introduction

Glioblastoma (GBM) is frequent in elderly patients, but their frailty provokes debate regarding optimal treatment in general, and the standard Stupp regimen in particular, although this is the mainstay for younger (<65 years) patients.

Methods

All patients with newly diagnosed GBM and age ≥ 70 who were referred to our institution for Stupp treatment were reviewed from 2004 to 2018. MGMT status was not available for treatment decision. The primary endpoint was overall survival (OS). Secondary outcomes were relapse-free survival (RFS), early (≤ 1 month after RCT) adverse neurological events (symptoms of intracranial hypertension and/or use of corticosteroids and/or hospitalization) and temozolomide hematologic toxicity assessed by CTCAE v5.

Results

128 patients were included. The median age was 74.1 (IQR: 72-77). 15% of patients were ≥80 years. 62.5% and 37.5% of patients fulfilled the criteria for RPA class I-II and III-IV, respectively. 81% of patients received the entire RCT and 28% completed the maintenance temozolomide. With median follow-up of 11.7 months (IQR: 6.5-17.5), median OS was 11.7 months (CI95%: 10-13 months). Median RFS was 9.5 months (CI95%: 9-10.5 months). 60% of patients had early adverse neurological events, of whom 44% had progression and 8% experienced grade ≥3 hematologic adverse events. RPA class III-IV and occurrence of neurological events were associated with lower OS rates, whereas post-operative neurological disabilities were not. Age ≥80 was not associated with worsened outcomes.

Conclusions

Stupp radiochemotherapy was feasible and effective for “real-life” elderly patients diagnosed with glioblastoma, even in the case of post-operative neurological disabilities.
Assessment of Triboelectricity in Colossal-Surface-Area-Lanthanum Oxide Nanocrystals Synthesized via Low-Temperature Hydrothermal Process
Authors: METI SUNIL , Sagar Hosangadi Prutvi , Rahman Mohammad Rizwanur , K Udaya Bhat 
Published: February 2021

Abstract
Triboelectric nanogenerators (TENGs) have marked their applications in various fields, most importantly, in medical devices. The electrical output of the TENGs mainly concentrated on parameters such as electrode separation distance, applied mechanical pressure, surface charge density, and overlapping surface-area. The surface-area of the active layer in TENGs plays a crucial role. Given this, the present contribution is the first report on the utilization of lanthanum oxide (La2O3) as an active material with a large surface-area (~72.33 m2/g) in TENGs. The nanocrystals of La2O3 have been successfully embedded into TENGs architecture through a high-quality screen-printed film with a Teflon-counter surface. The in-house test-rig of TENGs resulted in an output open-circuit voltage of 120 V and a short-circuit current of 23.7 μA. Further, the maximum power density is 7.125 W/m2 at an external load resistance of 30 MΩ. These results suggest that La2O3 is a suitable contender in various self-powered devices.
Green synthesize of fly ash-based zeolite X: A potential microwave absorbent
Authors: Shi Bin , Zhao Junjie , Chang Qing 
Published: February 2021

Abstract
Zeolite X is a potential electromagnetic wave (EMW) absorption material owning to its advantages of good dielectric properties, light weight and large specific surface area. Herein, high-purity zeolite X was prepared from fly ash using a green synthesis approach, in which only trace water was used and achieved zero discharge of waste water. Physiochemical properties of fabricated zeolite X were comprehensively evaluated through XRD, PSD, SEM, TG-DSC and BET test. XRD pattern shows the successful preparation of zeolite X with good crystallinity and high purity, and the average particle size is ~2.45 μm, which conforms to Gaussian distributions. The fabricated zeolite X exhibits typical octahedral structure and good thermal stability. It is noteworthy that the specific surface area is up to 473.56 m 2 /g, representing porous structure, which is beneficial to EMW attenuation. What’s more, the abundant crystal water and adsorbed water existing in the sample is conductive to dipole polarization, which further consume EMW energy. This study provides an eco-friendly approach to change waste into valuables, and moreover the synthesized zeolite X is a potential EMW absorbing material.
Fabrication and Characterization of a Light-Emitting Device Based on the CdS/ZnS Spherical
Quantum Dots
Authors: Hasanirokh Kobra , Asgari Asghar , Mohammadi Saber 
Published: February 2021

Abstract
In this work, we focus on the colloidal quantum dot based light-emitting diodes (QD-LEDs) performance. First, we synthesize the spherical QDs with a CdS core that covered with a wider band gap II–VI semiconductor acting as a shell (ZnS). In order to synthesize this nano crystal QDs with structure of CdS/ZnS/CdS/ZnS, we use a reverse micelle process. These four-layer quantum well quantum dots (QWQDs) can generate the white light emission. The positional design of different layers i.e., core/shell QD emitters is a critical factor for white emissive devices. The blue emission generated by CdS core mixes with green/orange components originating from ZnS inner shell and creates an efficiency white light emission. Then, we fabricate a white-QDLED with a device structure of ITO/ ZnO / QD / CBP/ MoO 3 / Al films. A thin film of CdS/ZnS/CdS/ZnS QDs is deposited by electrostatically assembled colloidal QD solutions. The experimental results show that the emission spectra of QDs and current density through the LED are controlled by varying the particle sizes. The peaks of absorbance and Photoluminescence (PL) spectrums get the red shifted as the dot size increases. Furthermore, this QD-LED with a smaller nano particle layer has a higher current density.
Study on shear properties of riveted lap joints of aircraft fuselage with different hole diameters
Authors: Li Ming , Tian Wei , Liao Wenhe , Hu Junshan , Wang Changrui 
Published: February 2021

Abstract
Riveting is the most important way to connect metal sheets, which is widely used in the connection of aircraft components. In this paper, the effect of different hole diameters on the shear properties of riveted lap joints were studied from the perspective of practical application. Considering the symmetry and the calculation time of the model, a 2D axisymmetric finite element method is established with the help of ABAQUS commercial finite element software, the validity of the finite element model is verified by experiment tests. Because the interference distribution has an important influence on the mechanical properties of riveted lap joints, the interference distribution and material flow characteristics in riveting process are analyzed in detail by using finite element method, and the shear characteristics of riveted lap joints in tensile process are explained. The variation of hole diameter with shear force under different squeeze force was obtained by shear test in order to explain the effect of hole diameter on the shear mechanical properties of riveted lap joint. In addition, the fracture mode and microstructure of the rivet shank were characterized by SEM and the formation process of brittleness and plastic fracture is discussed. Finally, the shear failure mechanism of riveted lap joint is analyzed in detail to provide guidance for engineering application. The test results show that all the specimens are both brittle and plastic mixed fracture modes of rivet shank, and the shear strength of the rivet increases with the increase of the hole diameter. Compared with increasing the squeeze force, increasing the hole diameter can effectively improve the shear strength of the riveted lap joint.
Socioeconomic Variation of Multimorbidity in Colombian Older Adults
Authors: Ballesteros Silvia Marcela , Moreno-Montoya José , Grooten Wilhelmus Johannes Andreas , Barrera-López Pedro , Hoz-Valle José A. De la 
Published: February 2021

Abstract
BackgroundMultimorbidity prevalence in the elderly is increasing worldwide. Variations regarding the socioeconomic characteristics of the individuals and their context have been described, mostly in high-income scenarios. This study aims to assess the magnitude and the socioeconomic factors associated with variations on multimorbidity in Colombia.MethodsA cross-sectional multilevel study with a nationally representative sample of 23 694 Colombian adults aged 60 years and older was conducted. Individual socioeconomic, demographic, childhood and health related characteristics, as well as group level variables (multidimensional poverty index and infectious diseases mortality rate) were analyzed. A two-level stepwise structural equation model was used to simultaneously adjust the individual and contextual effects. ResultsMultimorbidity prevalence was 62.3% (95% CI 61.7–62.9). In the multilevel adjusted models, age, female sex, having functional limitations, non-white ethnicity, high body mass index, higher income, physical inactivity, poverty during childhood and living in urban areas were associated with multimorbidity. The mediation analysis showed that living in rural areas was significantly associated with infectious disease mortality rate and other individual associations with multimorbidity were mediated by the multidimensional poverty variable. ConclusionsThis paper demonstrates a strong association between multimorbidity and poverty in a low-middle income country. Differences in the factors involved in the etiology of multimorbidity are expected among wealthy and poor countries regarding availability and prioritization of health services.
Curvularia Lunata as New Causal Pathogen of Tomato Early Blight Disease in Egypt
Authors: AbdElatah Heba-Alla S. , Sallam Nashwa M.A. , Mohamed Mohamed S. , Bagy Hadeel M. M. Khalil 
Published: February 2021

Abstract
Tomato plants displaying early blight symptoms were collected from different localities in the provinces of Assiut and Sohag, Egypt. The causal pathogens were isolated on potato dextrose agar plates. Pathogenicity tests with 48 isolates were carried out under greenhouse conditions on tomato cultivar (CV 844). All tested isolates caused symptoms of early blight disease with different degrees. The highest disease severity on tomato plants was found after inoculation with isolate No. 6 followed by isolates No. 20 and No. 31. The most pathogenic isolates were identified by sequence analysis using ITS1 and ITS4 primers. The analysis of the amplified sequences from fungal isolates No. 6, 20 and 31 displayed 99 - 100% nucleotide identity with Alternaria solani, Curvularia lunata and A. alternata, respectively. To our knowledge, this is the first report of Curvularia lunata as one of the causal pathogens of early blight disease of tomato plants in Egypt.
FDA-approved COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health system
Authors: Soundararajan Venky , Pawlowski Colin , Lenehan Patrick , Puranik Arjun , Agarwal Vineet , Venkatakrishnan AJ , Niesen Michiel , O'Horo John , Badley Andrew , Halamka John 
Published: February 2021

Abstract
Large Phase 3 clinical trials of the two FDA-approved COVID-19 vaccines, mRNA-1273 (Moderna) and BNT162b2 (Pfizer/BioNTech), have demonstrated efficacies of 94.1% (n = 30,420, 95% CI: 89.3-96.8) and 95% (n = 43,448, 95% CI: 90.3-97.6) in preventing symptomatic COVID-19, respectively. Given the ongoing vaccine rollout to healthcare personnel and residents of long-term care facilities, here we provide a preliminary assessment of real-world vaccination efficacy in 62,598 individuals from the Mayo Clinic and associated health system (Arizona, Florida, Minnesota, Wisconsin) between December 1st 2020 and February 8th 2021. Our retrospective analysis contrasts 31,299 individuals receiving at least one dose of either vaccine with 31,299 unvaccinated individuals who are propensity-matched based on demographics, location (zip code), and number of prior SARS-CoV-2 PCR tests. Administration of two COVID-19 vaccine doses was 89.0% effective in preventing SARS-CoV-2 infection (95% CI: 69.1-97.2%) with onset at least 36 days after the first dose. Furthermore, vaccinated patients who were subsequently diagnosed with COVID-19 had significantly lower 14-day hospital admission rates than propensity-matched unvaccinated COVID-19 patients (3.7% vs. 9.2%; Relative Risk: 0.4; p-value: 0.007). Building upon the previous randomized trials of these vaccines, this study demonstrates their real-world effectiveness in reducing the rates of SARS-CoV-2 infection and COVID-19 severity among individuals at highest risk for infection.
Isotope Analysis Reveals Differential Impacts of Artificial and Natural Afforestation on Soil Organic Carbon Dynamics in Abandoned Farmland
Authors: Di Dongrui , Huang GuangWei 
Published: February 2021

Abstract
Backgrounds A multitude of studies have applied different methods to study the dynamics of soil organic carbon (SOC), but the differential impact of artificial and natural vegetation restoration on SOC dynamic are still poorly understood. Methods and aims We investigated the SOC dynamics following artificial and natural afforestation in Loess Plateau of China, characterizing soil structure and stoichiometry using stable isotope carbon and radiocarbon models. We aim to compare SOC dynamics under both natural and artificial afforestation and examine how soil aggregate size classes control SOC dynamics based on stoichiometry and soil respiration.Results Total top soil SOC stocks, C:N and C:P of differently sized soil aggregates significantly increased following vegetation restoration. 13C results and Radiocarbon models indicated that the SOC decomposition rate and new SOC input rate were lower under natural afforestation than artificial afforestation and revealed the highest SOC decomposition rate under natural afforestation compared to other two ecosystems. Conclusions Vegetation restorations can accumulate SOC in top soils. Soil aggregates alternately play a dominant role in SOC accumulation following vegetation restoration; SOC loss from soil respiration was derived from microaggregates during afforestation. Recovery time is a key factor for the accumulation of SOC following afforestation.
International Consensus on Clinical Severity Scale Use in Evaluating Niemann-pick Disease Type C in Paediatric and Adult Patients: Results From a Delphi Study
Authors: Evans William , Patterson Marc , Platt Frances , Guldberg Christina , Mathieson Toni , Pacey Jessica 
Published: February 2021

Abstract
Background: Several scales have been developed in the past two decades to evaluate Niemann-Pick disease Type C (NPC) severity in clinical practice and trials. However, a lack of clarity concerning which scale to use in each setting is preventing the use of standardised assessments across the world, resulting in incomparable data sets and clinical trial outcome measures. This study aimed to establish agreed approaches for the use of NPC severity scales in clinical practice and research. Methods: A Delphi method of consensus development was used, comprising three survey rounds. In Round 1, participants were asked nine multiple-choice and open-ended questions to gather opinions on the six severity scales and domains. In Rounds 2 and 3, questions aimed to gain consensus on the opinions revealed in Round 1 using a typical Likert scale.Results: Nineteen experts, active in NPC paediatric and adult research and treatment, participated in this study. Of these, 16/19 completed Rounds 1 and 2 and 19/19 completed Round 3. Consensus (defined as ≥70% agreement or neutrality) was achieved for 66.7% of the multiple-choice questions in Round 2 and 83% of the multiple-choice questions in Round 3. Consensus was almost reached (68%) on the use of the 5-domain NPCCSS scale as the first choice in clinical practice. Consensus was reached (74%) for the 17-domain NPCCSS scale as the first choice in clinical trial settings, but the domains measured in the 5-domain scale should be prioritised as the primary endpoints. Experts called for educational and training materials on how to apply the NPCCSS (17- and 5-domains) for clinicians working in NPC.Conclusions: In achieving a consensus on the use of the 17-domain NPCCSS scale as the first choice for assessing clinical severity of NPC in clinical trial settings, but prioritising the domains in the 5-domain NPCCSS scale for routine clinical practice, this study can help to inform future discussion around the use of the existing NPC clinical severity scales. For routine clinical practice, the study helps provide clarity on which scale is favoured by a significant proportion of a representative body of experts, in this case, the 5-domain NPCCSS scale.
Dynamic Mitigation of Tearing Mode Instability in Current Sheet in Collisionless Plasma
Authors: Gu Yan-Jun , Kawata Shigeo , Bulanov Sergei 
Published: February 2021

Abstract
Dynamic mitigation for the tearing mode instability in the current sheet in collisionless plasma is demonstrated by applying a wobbling electron current beam. The initial small amplitude modulations imposed on the current sheet induce the electric current filamentation and the reconnection of the magnetic field lines. When the wobbling or oscillation motion is added from the electron beam having a form of a thin layer moving along the current sheet, the perturbation phase is mixed and consequently the instability growth is saturated remarkably, like in the case of the feed-forward control.
Meta-analysis of Cellular Toxicity for Graphene via Data-Mining the Literature and Machine Learning
Authors: Ma Ying , Wang Jianli , Wu Jingying , Tong Chuxuan , Zhang Ting 
Published: February 2021

Abstract
Background: Due to graphene is currently incorporated into various consumer product and numerous new applications, determining the relationships between physicochemical properties of graphene and their toxicity is a prominent concern for environmental and health risk analysis. Data from the literatures suggested that graphene exposure may resulted in cytotoxicity, however, the toxicity data of graphene is still insufficient to point out its side because of the complexity and heterogeneity of available data on potential risks of graphene. Methods and Results: Here, we developed a meta-analysis approach for assembling published evidence on cytotoxicity based on 792 related publications, 986 cell survival rate samples, 762 IC50 samples, and 100 LDH release samples. In this study, among corresponding attributes, we proved that the cytotoxicity of graphene assessed in the form of cell viability, IC50 and LDH can be primarily predicted from exposure dose and detection method, diameter and surface modification, detection method and organ source, respectively. Furthermore, this paper provides guidance regarding three optional data sets for above-mentioned three endpoints that are chiefly related to cellular toxicity for future studies and cross-validation studies based on machine learning tools including Random Forests (RFs), Support Vector Machine (SVM), LASSO regression, and Elastic Net were conducted for result verification. Conclusions: In summary, our study indicates that following rigorous methodological experimental and extract approaches accompanied with suitable machine learning tools, in parallel to continuous addition to reliable data set developed using our meta-analysis approach, will offer higher predictive power and accuracy, and also help to provide effective information on designing safe graphene.
Highly Rearranged Mitochondrial Genome in Falcolipeurus lice (Phthiraptera: Philopteridae) from Endangered Eagles
Authors: Nie Yu , Fu Yi-Tian , Zhang Yu , Deng Yuan-Ping , Tu Ya , Liu Guo-Hua 
Published: February 2021

Abstract
Background: Fragmented mitochondrial (mt) genomes and extensive mt gene rearrangements have been frequently reported from parasitic lice (Insecta: Phthiraptera). However, relatively little is available about the mt genomes from the family Philopteridae that is the most species-rich family within the suborder Ischnocera. Methods: Herein, we use next-generation sequencing to decode the mt genome sequences of Falcolipeurus suturalis and compared it with the mt genome sequences of F. quadripustulatus. Phylogenetic relationship of the concatenated amino acid sequence data for 13 protein-coding genes of the two Falcolipeurus lice and selected members of the family Philopteridae was evaluated using Bayesian inference (BI).Results: The complete mt genome of F. suturalis is a circular double-stranded DNA molecule of 16,659 bp, and contains 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, as well as three putative non-coding regions. The gene order in F. suturalis mt genome was rearranged compared with that of F. quadripustulatus, and they were radical different from other louse species and the ancestral insect. Phylogenetic analyses revealed that the clear genetic distinctiveness between F. suturalis and F. quadripustulatus (Bayesian posterior probabilities=1.0), and the genus Falcolipeurus is more closely related to the genus Ibidoecus than to other genera (Bayesian posterior probabilities=1.0). Conclusions: These novel datasets will help to better understand the gene rearrangements and phylogenetic position of Falcolipeurus and provide useful genetic markers for systematics and phylogenetic studies of bird lice.