bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economy analysis of the implementation of extruded tiles fabrication in a ceramic industry containing ornamental rock waste
Authors: Coelho de Azevedo Marilena , Teixeira Marvila Markssuel , Carla Girondi Delaqua Geovana , Fonseca Amaral Lucas , Colorado Henry , Maurício Fontes Vieira Carlos 
Published: February 2021

AbstractAs a result of the economic crisis faced in Brazil, industries in the red ceramic sector have economic problems. The objective of this work was to evaluate, technologically and economically, through analysis of economy, the implementation of the production of ceramic tiles, a material with higher added value than bricks and ceramic blocks, in a ceramic industry located in the state of Rio de Janeiro, Brazil. The ceramic tiles were produced containing the incorporation of ornamental rock waste (ORW). The state has a region that has a red ceramic pole, but produces only products with lower added value. For this, specimens were produced with four different ceramic masses burned at temperatures in the range of 800 to 1050°C. Three masses were produced with different clays from the region (ceramic mass 1, 2 and 3) and a ceramic mass 4 was evaluated containing the clay that presented the best results and with the inclusion of sand and ORW, aiming at the analysis of economy. It was found that the masses containing only clays showed satisfactory parameters of resistance, but showed deficiencies in water absorption. The fourth mass, however, presented acceptable values in all the evaluated properties and was chosen to carry out a full‐scale industrial test, which enabled the development of economic analysis and an economic analysis using the theory of real options. The results obtained in this last stage were also positive, providing an internal rate of return of 16.82%, above the minimum practiced rate of 15%, proving the efficiency of the economy applied to the manufacture of extruded tiles in the industries of the study region.
Controllable hydrothermal synthesis and photoluminescence properties of CaGd2(WO4)4:Eu3+ red‐emitting phosphor
Authors: Xu Yangyi , Wang Xiaohui , Wei Yunge , Liu Yuanxi , Li Guifang 
Published: February 2021

AbstractCaGd2(WO4)4:Eu3+ phosphors with controllable morphology were synthesized via the hydrothermal method. The influences of pH value, reaction time and Eu3+ concentration on the crystal structure, morphology, and photoluminescence properties of CaGd2(WO4)4:Eu3+ were studied. The pure tetragonal structure CaGd2(WO4)4 is obtained when the pH value is 8 and 9. Furthermore, by altering the pH value of the reaction solution, the morphologies of the CaGd2(WO4)4:Eu3+ phosphors evolve from spindle‐shaped grains to tetragonal plate‐like grains and finally to aggregated bulk particles. Under the 394 nm excitation, the phosphors display a bright red emission corresponding to the characteristic 4f‐4f transitions of Eu3+, and the intensity of emission peaks depends mainly on the pH value, the reaction time, and the Eu3+ concentration. The optimum photoluminescence performance is achieved for CaGd2‐x(WO4)4:xEu3+ (x = 1) phosphor synthesized at pH = 8 under the reaction time of 16 h. Finally, the thermal stability of the phosphors is analyzed at different ambient temperatures.
The dark side of social media: Stalking, online self‐disclosure and problematic sleep
Authors: Dhir Amandeep , Talwar Shalini , Kaur Puneet , Budhiraja Sunil , Islam Najmul 
Published: February 2021

AbstractThe proliferation of social media usage has led to the manifestation of certain negative behaviours that are now referred to as the ‘dark side’ of social media use. These behaviours are a matter of concern, as they are detrimental to people's well‐being. The present study examines the empirical association among social media stalking, online self‐disclosure, social media sleep hygiene, compulsive social media use and problematic sleep, most of which have been previously recognized as key dark side behaviours. While social media stalking is a relatively new and under‐explored phenomenon, its predecessor, the much‐castigated cyberstalking, has received sufficient scholarly attention. This study's hypothesized associations are grounded in cognitive‐behavioural theory, self‐awareness theory and problem behaviour theory, which we test using cross‐sectional data from 876 social media users. We further control for age and gender. The findings suggest that stalking and online self‐disclosure drive compulsive use and poor sleep hygiene, with stalking being the chief driver in both cases. Problematic sleep is influenced by stalking, compulsive use and poor sleep hygiene, with sleep hygiene having the strongest effect, while poor sleep hygiene and compulsive use also partially mediate the association of both stalking and online self‐disclosure with problematic sleep.
Dermoscopy in general dermatology (non‐neoplastic dermatoses): pitfalls and tips
Authors: Errichetti Enzo 
Published: February 2021

AbstractBackgroundDermoscopy is gaining appreciation in the spectrum of non‐neoplastic skin conditions, especially papulosquamous and granulomatous dermatoses. However, the use of dermoscopy in such diseases has not yet acquired a standard role in daily practice due to the lack of a structured approach as well as possible pitfalls limiting its accuracy.MethodsA descriptive analysis of the most common limitations/pitfalls described in the literature regarding dermoscopy of non‐neoplastic dermatoses was performed, also providing possible tips to deal with them.ResultsThe following items were analyzed: “two‐step” dermoscopic procedure and basic dermoscopic parameters in non‐neoplastic dermatoses, uniform dotted vessels in dermatoses other than psoriasis, pseudo‐Wickham striae, yellow sero‐crusts in non‐eczematous dermatoses, peripheral scaling collarette in conditions other than pityriasis rosea, orange areas in non‐granulomatous dermatoses, and dermoscopic variability of Grover disease according to histological subtype.ConclusionsDermoscopy is candidate to become a relevant part of diagnostic approach to non‐neoplastic dermatoses, yet only the use of a systematic/validated methodology and the in‐depth knowledge of possible pitfalls may optimize its use in this field.
Use of heat‐moisture treated maize starch to modify the properties of wheat flour and the quality of noodles
Authors: Ma Mengting , Li Zijun , Yang Feng , Wu Huaixiang , Huang Wuyang , Sui Zhongquan , Corke Harold 
Published: February 2021

SummaryWaxy, normal and high‐amylose maize starches were subjected to heat‐moisture treatment (HMT) and then added to wheat flour (WF) in different ratios (1%, 5% and 10%). The properties of blends and their cooked noodles were studied to investigate the effects of HMT starches. The incorporation of HMT starch in WF led to an increase in swelling power, peak viscosity and breakdown and to a decrease in setback, thus inhibiting retrogradation, hence enhancing resultant noodle softness. Compared to the same addition ratio of native starch to WF, HMT starch led to higher tensile strength and extensibility in resultant noodles. WF with added HMT starch had higher resistant starch than with native starch. This study showed that addition of HMT maize starch has potential to bring nutritional benefits. However, it is necessary to select the proper blending ratio and amylose content of starch to add, in consideration of its effect on noodle quality.
Extraction, physicochemical characterisation, and bioactive properties of ink melanin from cuttlefish (Sepiaesculenta)
Authors: Xie Jingwen , Li Hongyan , Che Hongxia , Dong Xiufang , Yang Xihong , Xie Wancui 
Published: February 2021

SummaryThe extracted melanin from Sepia esculenta was characterised by physicochemical properties and biological activities. The yields of melanin were 87.1%, 69.9%, and 62.5% by water extraction, enzymolysis and acidolysis, respectively. The ink melanin contained a characteristic indole structure with irregular spherical structures. Water extraction showed a positive effect on preserving the complete structure of melanin particles based on component analysis, whereas enzymes and acids had destructive effect. Water extraction melanin (WM) exhibited a certain thermal stability and light resistance. WM performed in radical scavenging in a dose‐dependent manner. The IC50 of WM for DPPH and ABTS was 99.8 and 104.2 μg mL−1, respectively. WM protected kojic acid and ascorbic acid from light radiation. As the exposure time to light radiation prolonged, the stability of kojic acid and ascorbic acid was preserved. It indicated that melanin might be potentially used as an antioxidant and photo‐protectant.
Epigenetic analysis reveals significant differential expression of miR‐378C and miR‐128‐2‐5p in a cohort of relapsed pediatric B‐acute lymphoblastic leukemia cases
Authors: Bhatia Prateek , Singh Minu , Singh Aditya , Sharma Pankaj , Trehan Amita , Varma Neelam 
Published: February 2021

AbstractIntroduction and ObjectiveEpigenetic changes play a major role in mediating chemoresistance and relapse in pediatric ALL, and hence in current pilot study, we tried to identify DNA methylation, miRNA expression, and copy number variations (CNVs) in a cohort of relapse pediatric B‐ALL cases.MethodologyDNA methylation, miRNA expression, and CNV analysis were performed in a total of 14, 16, and 18 cases as diagnosis‐relapse samples. Briefly, DNA methylation was performed using Infinium HumanMethylation850 chip and data analyzed using RnBeads. miRNA was sequenced on illumina NextSeq500 platform for 20M 75bp SE reads and analyzed by DESeq2. CNVs were assessed by MLPA assay using the ALL P‐335 probemix kit and analyzed by coffalyzer.net.ResultsOn methylation analysis, oncogenes MYCN, MYB, and EGFR and tumor suppressor genes MDM4 & BCL11B were found differentially expressed as compared to controls (p‐0.03). In addition, protooncogenes—AXL, HCK, MED12, and ETS2—were hypomethylated/overexpressed in 4 or more cases (P < .05). miRNA analysis revealed significant differential expression of miR‐128‐2‐5p and miR‐378C (p‐4.4e‐15 and p‐6.4E‐12) in relapse samples. CNV analysis revealed that frequency of good and intermediate/poor risk CNV profile at diagnosis was nearly equal (40% vs 60%). However, CDKN2A/2B and IKZF1 gene CNVs if present in initial diagnostic clone usually persisted in relapse clone.Discussion and ConclusionOur pilot study highlights two miRNAs (miR‐128‐2‐5p and miR‐378C) as possible candidate biomarkers of relapsed B‐ALL. However, these miRNAs and hypomethylated protooncogene signature noted in our data needs validation in a larger series of B‐ALL.
Identification of a mitogen‐activated protein kinase kinase (AccMKK4) from Apis cerana cerana and its involvement in various stress responses
Authors: Guo D. , Zhao G. , Li G. , Wang C. , Wang H. , Liu Z. , Xu B. , Guo X. 
Published: February 2021

AbstractThe mitogen‐activated protein kinase (MAPK) cascade pathway is a ubiquitous signal transduction pathway in eukaryotes that regulates a variety of immune responses. This study accomplished the first isolation of an AccMKK4 gene from Apis cerana cerana and explored its function. Yeast two‐hybrid experiments proved that AccMKK4 can interact with Accp38b, and the silencing of AccMKK4 in honeybees downregulated the expression level of Accp38b, which suggests that AccMKK4 might participate in the oxidative stress response through the p38 MAPK pathway. Tissue‐specific expression levels of AccMKK4 analysis showed that AccMKK4 in the thorax, particularly muscle tissue, was higher than that in other tissues. The qRT‐PCR results from different conditions demonstrated that AccMKK4 responds to various environmental stresses. After AccMKK4 silencing, the transcription level of some antioxidant genes and the activity of antioxidant‐related enzymes are reduced, which indicated that AccMKK4 plays an important role in resistance against oxidative stress caused by external stimuli. In summary, our findings indicate that AccMKK4 probably plays an indispensable role in the response of honeybees to environmental stress and might aid for further research on the role of the MAPK cascade pathway in the antioxidant defence mechanisms of insects.
Harnessing CD8+ T‐cell exhaustion to treat type 1 diabetes
Authors: Kwong Chun‐Ting J , Selck Claudia , Tahija Krisna , McAnaney Lachlan J , Le Dan V , Kay Thomas WH , Thomas Helen E , Krishnamurthy Balasubramanian 
Published: February 2021

AbstractAlthough immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet in routine clinical use or able to achieve insulin independence in patients. In addition to this, the principles of T1D treatment remain essentially unchanged since the isolation of insulin, almost a century ago. T1D is characterized by insulin deficiency as a result of destruction of insulin‐producing beta cells mediated by autoreactive T cells. Therapies that target beta‐cell antigen‐specific T cells are needed to prevent T1D. CD8+ T‐cell exhaustion is an emerging area of research in chronic infection, cancer immunotherapy, and more recently, autoimmunity. Recent data suggest that exhausted T‐cell populations are associated with improved markers of T1D. T‐cell exhaustion is both characterized and mediated by inhibitory receptors. This review aims to identify which inhibitory receptors may prove useful to induce T‐cell exhaustion to treat T1D and identify limitations and gaps in the current literature.
Epithelial cell‐derived CD83 restores immune tolerance in the airway mucosa by inducing regulatory T‐cell differentiation
Authors: Mo Li‐Hua , Luo Xiang‐Qian , Yang Gui , Liu Jiang‐Qi , Yang Li‐Teng , Liu Zhi‐Qiang , Wang Shuai , Liu Da‐Bo , Liu Zhi‐Gang , Yang Ping‐Chang 
Published: February 2021

AbstractThe mechanism of generation of regulatory T cells (Treg) remains incompletely understood. Recent studies show that CD83 has immune regulatory functions. This study aims to investigate the role of epithelial cell‐derived CD83 in the restoration of immune tolerance in the airway mucosa by inducing the Treg differentiation. In this study, CD83 and ovalbumin (OVA)‐carrying exosomes were generated from airway epithelial cells. An airway allergy mouse model was developed to test the role of CD83/OVA‐carrying exosomes in the suppression of airway allergy by inducing Treg generation. We observed that mouse airway epithelial cells expressed CD83 that could be up‐regulated by CD40 ligand. The CD83 deficiency in epithelial cells retarded the Treg generation in the airway mucosa. CD83 up‐regulated transforming growth factor‐β‐inducible early gene 1 expression in CD4+ T cells to promote Foxp3 expression. Exposure of primed CD4+ T cells to CD83/OVA‐carrying exosomes promoted antigen‐specific Treg generation. Administration of CD83/OVA‐carrying exosomes inhibited experimental airway allergic response. In summary, airway epithelial cells express CD83 that is required in the Treg differentiation in the airway mucosa. Administration of CD83/OVA‐carrying exosomes can inhibit airway allergy that has the translation potential in the treatment of airway allergic disorders.
Consumer experiences of community‐based residential mental health rehabilitation for severe and persistent mental illness: A pragmatic grounded theory analysis
Authors: Parker Stephen , Wyder Marianne , Pommeranz Matthew , Newman Ellie , Meurk Carla , Dark Frances 
Published: February 2021

AbstractSemi‐structured interviews were used to explore the consumer experience of community‐based residential mental health rehabilitation support at Community Care Units in Australia. These clinical services provide recovery‐oriented residential rehabilitation to people affected by severe and persistent mental illness. Typically, nurses occupy the majority of staff roles. However, two of the three sites in the study were trialling a novel integrated staffing model where the majority of staff were people with a lived experience of mental illness employed as peer support workers (PSWs). The interviews explored consumers' experiences of care 12–18 months after admission. Fifteen interviews were completed with an independent interviewer. Most participants were diagnosed with schizophrenia or a related psychotic disorder. The analysis followed a pragmatic approach to grounded theory. Consumers viewed the CCU favourably, emphasizing the value of the relationships formed with staff and co‐residents. No major differences in consumers' experience under the traditional versus integrated staffing models were identified; however, those from the integrated staffing model sites valued the contributions of the peer support workers. The understanding of the consumer experience emerging through this study aligned with their expectations of the service at the time of commencement.
Parents' preferences for preventive and curative dental services: A comparison between fissure sealant and composite filling using willingness‐to‐pay method
Authors: Saadatfar Navid , Jadidfard Mohammad‐Pooyan 
Published: February 2021

AbstractBackgroundThe early years of life play a significant role in the lifelong health of humans and parents have an important role in healthcare decision making. Thus, it seems necessary for policymakers and clinicians to be aware of how parents value pediatric health services. Willingness to pay (WTP) is a recommended method for measuring the stated utility of health services/goods or health states.AimThis study aimed to elicit and compare parents’ WTP for health services such as fissure sealant and composite filling.DesignAn originally developed questionnaire was used to guide interviews with a sample of 290 parents attending a public pediatric healthcare center. Related‐samples Wilcoxon signed‐rank test was performed for comparing the difference in absolute WTP amounts between the two services, and linear regression was used to assess the association between WTP and relevant variables using SPSS version 21.ResultsMean WTP for fissure sealant and filling was 269 724 and 555 327 Tomans, respectively, and the difference between them was statistically significant (P < .001). Higher WTP amounts found in both services were associated with income levels of 4 and 5 (P < .05).ConclusionsRespondents highly valued the considered services and stated a significantly higher relative preference for filling. Public awareness should be promoted about the importance of prevention of oral health diseases and the attributes of the oral healthcare system services.
Applications of artificial intelligence for hypertension management
Authors: Tsoi Kelvin , Yiu Karen , Lee Helen , Cheng Hao‐Min , Wang Tzung‐Dau , Tay Jam‐Chin , Teo Boon Wee , Turana Yuda , Soenarta Arieska Ann , Sogunuru Guru Prasad , Siddique Saulat , Chia Yook‐Chin , Shin Jinho , Chen Chen‐Huan , Wang Ji‐Guang , Kario Kazuomi ,   the HOPE Asia Network
Published: February 2021

AbstractThe prevalence of hypertension is increasing along with an aging population, causing millions of premature deaths annually worldwide. Low awareness of blood pressure (BP) elevation and suboptimal hypertension diagnosis serve as the major hurdles in effective hypertension management. The advent of artificial intelligence (AI), however, sheds the light of new strategies for hypertension management, such as remote supports from telemedicine and big data‐derived prediction. There is considerable evidence demonstrating the feasibility of AI applications in hypertension management. A foreseeable trend was observed in integrating BP measurements with various wearable sensors and smartphones, so as to permit continuous and convenient monitoring. In the meantime, further investigations are advised to validate the novel prediction and prognostic tools. These revolutionary developments have made a stride toward the future model for digital management of chronic diseases.
Hypertension and chronic kidney disease in Asian populations
Authors: Teo Boon Wee , Chan Gek Cher , Leo Christopher Cheang Han , Tay Jam Chin , Chia Yook‐Chin , Siddique Saulat , Turana Yuda , Chen Chen‐Huan , Cheng Hao‐Min , Hoshide Satoshi , Minh Huynh Van , Sogunuru Guru Prasad , Wang Tzung‐Dau , Kario Kazuomi 
Published: February 2021

AbstractThe countries of Asia are home to multiple ethnicities. There are ethnic differences in diet, culture, and attitudes towards health screening, access to care, and treatment of chronic diseases. Chronic kidney disease (CKD) and end‐stage kidney disease (ESKD) have rising incidence and prevalence due to increased affliction with non‐communicable diseases of diabetes and hypertension. To prevent the expensive complications of ESKD, one of the most important risk factors to control is hypertension in patients with CKD. We performed a narrative review on the prevalence of CKD in patients with hypertension, the prevalence and control of hypertension in patients with CKD, and the dietary sodium intake in CKD populations.
Paeonol attenuates inflammation by confining HMGB1 to the nucleus
Authors: Miao Jifei , Zhong Jun , Lan Jiao , Ye Sen , Ye Peng , Li Siyan , You Aijia , Chen Xianjie , Liu Xiaoyi , Li Hui 
Published: February 2021

AbstractInflammation is a biological process that exists in a large number of diseases. If the magnitude or duration of inflammation becomes uncontrolled, inflammation may cause pathological damage to the host. HMGB1 and NF‐κB have been shown to play pivotal roles in inflammation‐related diseases. New drugs aimed at inhibiting HMGB1 expression have become a key research focus. In the present study, we showed that paeonol (Pae), the main active component of Paeonia suffruticosa, decreases the expression of inflammatory cytokines and inhibits the translocation of HMGB1 induced by lipopolysaccharide (LPS). By constructing HMGB1‐overexpressing (HMGB1+) and HMGB1‐mutant (HMGB1m) RAW264.7 cells, we found that the nuclear HMGB1 could induce an LPS‐tolerant state in RAW264.7 cells and that paeonol had no influence on the expression of inflammatory cytokines in HMGB1m RAW264.7 cells. In addition, the anti‐inflammatory property of paeonol was lost in HMGB1 conditional knockout mice, indicating that HMGB1 is a target of paeonol and a mediator through which paeonol exerts its anti‐inflammatory function. Additionally, we also found that HMGB1 and P50 competitively bound with P65, thus inactivating the NF‐κB pathway. Our research confirmed the anti‐inflammation property of paeonol and suggests that inhibiting the translocation of HMGB1 could be a new strategy for treating inflammation.
Brahma‐Related Gene‐1 (BRG1) promotes the malignant phenotype of glioblastoma cells
Authors: Wang Yinan , Yang Chuan He , Schultz Andrew P. , Sims Michelle M. , Miller Duane D. , Pfeffer Lawrence M. 
Published: February 2021

AbstractGlioblastoma multiforme (GBM) is an aggressive malignant brain tumour that is resistant to existing therapeutics. Identifying signalling pathways deregulated in GBM that can be targeted therapeutically is critical to improve the present dismal prognosis for GBM patients. In this report, we have identified that the BRG1 (Brahma‐Related Gene‐1) catalytic subunit of the SWI/SNF chromatin remodelling complex promotes the malignant phenotype of GBM cells. We found that BRG1 is ubiquitously expressed in tumour tissue from GBM patients, and high BRG1 expression levels are localized to specific brain tumour regions. Knockout (KO) of BRG1 by CRISPR‐Cas9 gene editing had minimal effects on GBM cell proliferation, but significantly inhibited GBM cell migration and invasion. BRG1‐KO also sensitized GBM cells to the anti‐proliferative effects of the anti‐cancer agent temozolomide (TMZ), which is used to treat GBM patients in the clinic, and selectively altered STAT3 tyrosine phosphorylation and gene expression. These results demonstrate that BRG‐1 promotes invasion and migration, and decreases chemotherapy sensitivity, indicating that it functions in an oncogenic manner in GBM cells. Taken together, our findings suggest that targeting BRG1 in GBM may have therapeutic benefit in the treatment of this deadly form of brain cancer.