bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two point functions in defect CFTs
Authors: Herzog Christopher P. , Shrestha Abhay 
Published: April 2021

Abstract
This paper is designed to be a practical tool for constructing and investigating two-point correlation functions in defect conformal field theory, directly in physical space, between any two bulk primaries or between a bulk primary and a defect primary, with arbitrary spin. Although geometrically elegant and ultimately a more powerful approach, the embedding space formalism gets rather cumbersome when dealing with mixed symmetry tensors, especially in the projection to physical space. The results in this paper provide an alternative method for studying two-point correlation functions for a generic d-dimensional conformal field theory with a flat p-dimensional defect and d − p = q co-dimensions. We tabulate some examples of correlation functions involving a conserved current, an energy momentum tensor and a Maxwell field strength, while analysing the constraints arising from conservation and the equations of motion. A method for obtaining bulk-to-defect correlators is also explained. Some explicit examples are considered: free scalar theory on ℝp× (ℝq/ℤ2) and a free four dimensional Maxwell theory on a wedge.
Diabetes-related lower extremity complications in a multi-ethnic Asian population: a 10 year observational study in Singapore
Authors: Riandini Tessa , Pang Deanette , Toh Matthias P. H. S. , Tan Chuen Seng , Liu Daveon Y. K. , Choong Andrew M. T. L. , Chandrasekar Sadhana , Tai E Shyong , Tan Kelvin B. , Venkataraman Kavita 
Published: April 2021

AbstractAims/hypothesisDiabetes progression and complication risk are different in Asian people compared with those of European ancestry. In this study, we sought to understand the epidemiology of diabetes-related lower extremity complications (DRLECs: symptomatic peripheral arterial disease, ulceration, infection, gangrene) and amputations in a multi-ethnic Asian population.MethodsThis was a retrospective observational study using data obtained from one of three integrated public healthcare clusters in Singapore. The population consisted of individuals with incident type 2 diabetes who were of Chinese, Malay, Indian or Other ethnicity. We examined incidence, time to event and risk factors of DRLECs and amputation.ResultsBetween 2007 and 2017, of the 156,593 individuals with incident type 2 diabetes, 20,744 developed a DRLEC, of whom 1208 underwent amputation. Age- and sex-standardised incidence of first DRLEC and first amputation was 28.29/1000 person-years of diabetes and 8.18/1000 person-years of DRLEC, respectively. Incidence of both was highest in individuals of Malay ethnicity (DRLEC, 36.09/1000 person-years of diabetes; amputation, 12.96/1000 person-years of DRLEC). Median time from diabetes diagnosis in the public healthcare system to first DRLEC was 30.5 months for those without subsequent amputation and 10.9 months for those with subsequent amputation. Median time from DRLEC to first amputation was 2.3 months. Older age (p < 0.001), male sex (p < 0.001), Malay ethnicity (p < 0.001), Indian ethnicity (p = 0.014), chronic comorbidities (nephropathy [p < 0.001], heart disease [p < 0.001], stroke [p < 0.001], retinopathy [p < 0.001], neuropathy [p < 0.001]), poorer or missing HbA1c(p < 0.001), lower (p < 0.001) or missing (p = 0.002) eGFR, greater or missing BMI (p < 0.001), missing LDL-cholesterol (p < 0.001) at diagnosis, and ever-smoking (p < 0.001) were associated with higher hazard of DRLEC. Retinopathy (p < 0.001), peripheral vascular disease (p < 0.001), poorer HbA1c(p < 0.001), higher (p = 0.009) or missing (p < 0.001) LDL-cholesterol and missing BMI (p = 0.008) were associated with higher hazard of amputation in those with DRLEC. Indian ethnicity (p = 0.007) was associated with significantly lower hazard of amputation.Conclusions/interpretationThis study has revealed important ethnic differences in risk of diabetes-related lower limb complications, with Malays most likely to progress to DRLEC. Greater research efforts are needed to understand the aetiopathological and sociocultural processes that contribute to the higher risk of lower extremity complications among these ethnic groups.Graphical abstract
WEDM single crater asymmetry
Authors: Esteves Paulo M. B. , Wiessner Moritz , Costa João V. M. R. , Sikora Maria , Wegener Konrad 
Published: April 2021

AbstractIn wire electrical discharge machining (WEDM), the erosion is made through a series of overlapped craters. The shape of these craters has a relevant impact on the characteristics of the machined surface, from surface roughness to heat effects during the spark. Current models on EDM process do not represent specific WEDM characteristics, such as radial asymmetry of the crater or geometrical effects on the crater shape. In order to characterize the crater’s dimensions in WEDM, single discharge experiments are performed on polished steel for pulses with different energy levels. A 3D optical microscope is used to map the single craters’ topographies (experimental work). To capture the craters’ dimensions, an ellipsoidal equation is applied with a Levenberg–Marquardt algorithm. The ellipsoidal equation is capable of identifying the dimensions along the wire length, perpendicular to the wire and the depth of the crater. The ratio between the dimension along the wire and the dimension perpendicular to the wire is used to define a crater’s aspect ratio and characterizes its elongation. The aspect ratio of the single craters is found to be dependent on the pulse energy. Low-energy pulses create rounder craters, while high-energy pulses form elongated craters that are longer along the wire length. Such behavior suggests that the crater formation is constricted by the wire geometry, having a preferential direction of growth, along the wire length.
Short-baseline interferometry local-tie experiments at the Onsala Space Observatory
Authors: Varenius Eskil , Haas Rüdiger , Nilsson Tobias 
Published: April 2021

AbstractWe present results from observation, correlation and analysis of interferometric measurements between the three geodetic very long baseline interferometry (VLBI) stations at the Onsala Space Observatory. In total, 25 sessions were observed in 2019 and 2020, most of them 24 h long, all using X band only. These involved the legacy VLBI station ONSALA60 and the Onsala twin telescopes, ONSA13NE and ONSA13SW, two broadband stations for the next-generation geodetic VLBI global observing system (VGOS). We used two analysis packages: $$\nu $$
ν
Solve to pre-process the data and solve ambiguities, and ASCOT to solve for station positions, including modelling gravitational deformation of the radio telescopes and other significant effects. We obtained weighted root mean square post-fit residuals for each session on the order of 10–15 ps using group-delays and 2–5 ps using phase-delays. The best performance was achieved on the (rather short) baseline between the VGOS stations. As the main result of this work, we determined the coordinates of the Onsala twin telescopes in VTRF2020b with sub-millimetre precision. This new set of coordinates should be used from now on for scheduling, correlation, as a priori for data analyses, and for comparison with classical local-tie techniques. Finally, we find that positions estimated from phase-delays are offset $$\sim +3$$

∼
+
3

mm in the up-component with respect to group-delays. Additional modelling of (elevation dependent) effects may contribute to the future understanding of this offset.
Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients
Authors: Rodin William , Sundström Patrik , Ahlmanner Filip , Szeponik Louis , Zajt Kamil Kajetan , Wettergren Yvonne , Bexe Lindskog Elinor , Quiding Järbrink Marianne 
Published: April 2021

AbstractMucosal-associated invariant T (MAIT) cells are unconventional T cells recognizing microbial metabolites, presented by the invariant MR1 protein. Upon activation, MAIT cells rapidly secrete cytokines and exert cytotoxic functions, and may thus be highly relevant also in tumor immunity. MAIT cells accumulate in colon tumors, but in contrast to other cytotoxic T cell subsets, their presence in tumors has been associated with worse patient outcome. Here we investigated if exhaustion may contribute to reduced anti-tumor immunity by MAIT cells. Freshly isolated lymphocytes from colon tumors, unaffected tissue and blood from the same patients were analyzed by flow cytometry to detect MAIT cells with effector functions that are relevant for tumor immunity, and their expression of inhibitory receptors and other exhaustion markers. Our studies show that MAIT cells with a PD-1highTim-3+CD39+ terminally exhausted phenotype and an increased proliferation accumulate in colon tumors. The exhausted MAIT cells have reduced polyfunctionality with regard to production of important anti-tumor effector molecules, and blocking antibodies to PD-1 partly improved activation of tumor-infiltrating MAIT cells in vitro. We conclude that the tumor microenvironment leads to exhaustion not only of conventional T cells, but also MAIT cells, and that checkpoint blockade therapy may be useful also to reinvigorate tumor-infiltrating MAIT cells.
Effect of n-3 PUFA on extracellular matrix protein turnover in patients with psoriatic arthritis: a randomized, double-blind, placebo-controlled trial
Authors: Holm Nielsen Signe , Sardar Samra , Siebuhr Anne Sofie , Schlemmer Annette , Schmidt Erik Berg , Bay-Jensen Anne-Christine , Karsdal Morten A. , Christensen Jeppe Hagstrup , Kristensen Salome 
Published: April 2021

AbstractPsoriatic arthritis (PsA) is a chronic inflammatory disease characterized by involvement of skin, axial and peripheral skeleton. An altered balance between extracellular matrix (ECM) formation and breakdown is a key event in PsA, and changes in ECM protein metabolites may provide insight to tissue changes. Dietary fish oils (n-3 PUFA) might affect the inflammation driven tissue turnover. The aim was to evaluate ECM metabolites in patients with PsA compared to healthy individuals and investigate the effects of n-3 PUFA. The 24-week randomized, double-blind, placebo-controlled trial of PUFA included 142 patients with PsA. Fifty-seven healthy individuals were included for comparison. This study is a sub-study investigating biomarkers of tissue remodelling as secondary outcomes. Serum samples at baseline and 24 weeks and healthy individuals were obtained, while a panel of ECM metabolites reflecting bone and soft tissue turnover were measured by ELISAs: PRO-C1, PRO-C3, PRO-C4, C1M, C3M, C4M, CTX-I and Osteocalcin (OC). C1M, PRO-C3, PRO-C4 and C4M was found to be elevated in PsA patients compared to the healthy individuals (from 56 to 792%, all p < 0.0001), where no differences were found for OC, CTX-I, PRO-C1 and C3M. PRO-C3 was increased by 7% in patients receiving n-3 PUFA after 24 weeks compared to baseline levels (p = 0.002). None of the other biomarkers was changed with n-3 PUFA treatment. This indicates that tissue turnover is increased in PsA patients compared to healthy individuals, while n-3 PUFA treatment for 24 weeks did not have an effect on tissue turnover. Trial registration NCT01818804. Registered 27 March 2013–Completed 18 February 2016. https://clinicaltrials.gov/ct2/show/NCT01818804?term=NCT01818804&rank=1
Measuring standing hindfoot alignment: reliability of different approaches in conventional x-ray and cone-beam CT
Authors: Brandenburg Leonard Simon , Siegel Markus , Neubauer Jakob , Merz Johanna , Bode Gerrit , Kühle Jan 
Published: April 2021

Abstract
Introduction
Currently there is no consensus how hindfoot alignment (HA) should be assessed in CBCT scans. The aim of this study is to investigate how the reliability is affected by the anatomical structures chosen for the measurement.

Materials and methods
Datasets consisting of a Saltzman View (SV) and a CBCT of the same foot were acquired prospectively and independently assessed by five raters regarding HA. In SVs the HA was estimated as follows: transversal shift between tibial shaft axis and heel contact point (1); angle between tibial shaft axis and a tangent at the medial (2) or lateral (3) calcaneal wall. In CBCT the HA was estimated as follows: transversal shift between the centre of the talus and the heel contact point (4); angle between a perpendicular line and a tangent at the medial (5) or lateral (6) calcaneal wall; angle between the distal tibial surface and a tangent at the medial calcaneal wall (7). Intraclass correlation coefficients (ICC) were calculated to assess inter-rater reliability. A linear regression was performed to compare the different measurement regarding their correlation.

Results
32 patients were included in the study. The ICCs for the measurements 1–7 were as follows: (1) 0.924 [95% CI 0.876–0.959] (2) 0.533 [95% CI 0.377–0.692], (3) 0.553 [95% CI 0.399–0.708], (4) 0.930 [95% CI 0.866–0.962], (5) 0.00 [95% CI − 0.111 to 0.096], (6) 0.00 [95% CI − 0.103 to 0.111], (7) 0.152 [95% CI 0.027–0.330]. A linear regression between measurement 1 and 4 showed a correlation of 0.272 (p = 0.036).

Conclusions
It could be shown that reliability of measuring HA depends on the investigated anatomical structure. Placing a tangent along the calcaneus (2, 3, 5, 6, 7) was shown to be unreliable, whereas determining the weight-bearing heel point (1, 4) appeared to be a reliable approach. The correlation of the measurement workflows is significant (p = 0.036), but too weak (0.272) to be used clinically.
Learning of across- and within-task contingencies modulates partial-repetition costs in dual-tasking
Authors: Pelzer Lasse , Naefgen Christoph , Gaschler Robert , Haider Hilde 
Published: April 2021

AbstractDual-task costs might result from confusions on the task-set level as both tasks are not represented as distinct task-sets, but rather being integrated into a single task-set. This suggests that events in the two tasks are stored and retrieved together as an integrated memory episode. In a series of three experiments, we tested for such integrated task processing and whether it can be modulated by regularities between the stimuli of the two tasks (across-task contingencies) or by sequential regularities within one of the tasks (within-task contingencies). Building on the experimental approach of feature binding in action control, we tested whether the participants in a dual-tasking experiment will show partial-repetition costs: they should be slower when only the stimulus in one of the two tasks is repeated from Trial n − 1 to Trial n than when the stimuli in both tasks repeat. In all three experiments, the participants processed a visual-manual and an auditory-vocal tone-discrimination task which were always presented concurrently. In Experiment 1, we show that retrieval of Trial n − 1 episodes is stable across practice if the stimulus material is drawn randomly. Across-task contingencies (Experiment 2) and sequential regularities within a task (Experiment 3) can compete with n − 1-based retrieval leading to a reduction of partial-repetition costs with practice. Overall the results suggest that participants do not separate the processing of the two tasks, yet, within-task contingencies might reduce integrated task processing.
Impact of the COVID-19 lockdown on screen media use in patients referred for ADHD to child and adolescent psychiatry: an introduction to problematic use of the internet in ADHD and results of a survey
Authors: Werling Anna Maria , Walitza Susanne , Drechsler Renate 
Published: April 2021

AbstractThe COVID-19 outbreak and lockdown have been associated with multiple consequences for mental health, including an excessive and potentially harmful increase in screen media use. The specific consequences for children, adolescents and young adults with ADHD are still unknown. In the first part of this study, a short review of problematic use of the internet (PUI) in ADHD is presented, showing that patients with ADHD are at risk for different aspects of PUI, such as excessive gaming or problematic social media use. In the second part, we report original data of an online survey on screen media use before, during and after the lockdown completed by parents of children and adolescents clinically referred for ADHD. Parents rated children’s/adolescents’ media-related behavior and media time on a new screening questionnaire for PUI. Each item was rated three times, referring to the observed behavior before, during and 1–2 months after the lockdown. N = 126 parents of patients referred for ADHD aged 10–18 years participated in the study. Total media time increased by 46% during the lockdown and did not completely return to pre-Corona levels afterwards. Patients with difficulties concentrating, high irritability or deterioration of ADHD problems under lockdown spent more time with screen media than those with milder or no such problems. While the effects of the lockdown on screen media use and its negative impact on everyday life appear to be largely reversible, a small proportion of patients with ADHD apparently continue to show increased media use.
Zusammenhänge zwischen Empathie, therapeutischer Haltung und Wirkeffizienz
Authors: Steinmair Dagmar , Löffler-Stastka Henriette 
Published: April 2021

ZusammenfassungEmpathisch sein heißt, fühlen und verstehen können, was andere fühlen. Vermuten zu können, was das Gegenüber fühlt, denkt und wünscht, beruht auf der Fähigkeit, eigene Gefühle und Gedanken als getrennt von jenen anderer wahrnehmen und regulieren zu können. Definierte Therapieerfolge mit adäquatem Aufwand erreichen zu können, verlangt ein Fokussieren auf Wesentliches und Wichtiges. Die Empathie ist im Bereich der Psychotherapie jener Faktor, für den für sich genommen die höchste Effektstärke nachgewiesen werden konnte. Empathietraining ermöglicht eine bessere soziale Performance. Im Falle von Defiziten in sozialer Kompetenz ist störungsunabhängig ein besonders hoher Leidensdruck nachweisbar.
Subcutaneous and visceral adipose tissue in patients with primary and recurrent incisional hernia
Authors: Qandeel H. , Chew C. , Young D. , O’Dwyer P. J. 
Published: April 2021

Abstract
Purpose
Visceral obesity rather than body mass index has been reported to be associated with a higher incidence of incisional hernias. The aim of this study was to examine the relationship between CT measured adipose tissue and muscle in primary and recurrent incisional hernia.

Methods
Patients with a ‘Primary’ or ‘Recurrent incisional hernia’ were obtained from a prospective cohort of patients who were being assessed for incisional hernia repair over a 2-year period. Computerised tomography (CT)-images were analysed using NIH Image-J software to quantify adipose tissue and skeletal muscle cross-sectional areas at the level of lumber vertebra 3/4 using standard Hounsfield units. To test inter-observer ‘absolute agreement’, each parameter was measured independently by two investigators and reliability analysis performed.

Results
Thirty-six patients were included in the study: 15 had a Primary while 21 had a Recurrent incisional hernia. Both groups had similar baseline characteristics. Reliability analysis for CT-measured areas showed very high interclass correlation coefficient (ICC) between observers. Patients in the recurrent group had significantly greater subcutaneous adipose tissue (SAT) [median = 321.9cm2 vs 230.9cm2, p = 0.04] and visceral adipose tissue (VAT) [median = 221.1cm2 vs 146.8cm2, p = 0.03] than those in the primary group. There was no difference in skeletal muscle areas for right [median = 2.8cm2 vs 2.9cm2] and left [median = 3.7cm2 vs 4.1cm2] rectus muscles between groups.

Conclusion
Our study shows that patients with a recurrent incisional hernia have significantly more subcutaneous and visceral adipose tissue than those with a primary incisional hernia. Further studies in this area are required if we are to reduce the burden of recurrent hernia following repair of a primary incisional hernia.
Comparison of urethral sling surgery and non-ablative vaginal Erbium:YAG laser treatment in 327 patients with stress urinary incontinence: a case-matching analysis
Authors: Okui Nobuo , Miyazaki Hironari , Takahashi Wataru , Miyauchi Toshihide , Ito Chikako , Okui Machiko , Shigemori Kaori , Miyazaki Yoshiharu , Vizintin Zdenko , Lukac Matjaž 
Published: April 2021

AbstractStress urinary incontinence (SUI) occurs when abdominal pressure, such as from coughing or sneezing, causes urine leakage. We retrospectively compared tension-free vaginal tape (TVT) and non-ablative vaginal Erbium:YAG laser treatment (VEL) by propensity score (PS) analysis in women with SUI. No PS analysis studies have investigated urethral sling surgery using polypropylene TVT and VEL for SUI. Data from patients aged 35–50 years who were treated for SUI and registered at several institutions were selected. Patients with medical records covering 1 year for the 1-h pad test, who completed the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) and the Overactive Bladder Symptom Score (OABSS), were included. We analyzed 102, 113, and 112 patients in the TVT, VEL, and control groups, respectively. Compared with the control group, the TVT and VEL groups exhibited significant improvement in the 1-h pad test and ICIQ-SF. In the PS analysis, the TVT and VEL groups similarly improved in the 1-h pad test and ICIQ-SF. As for the OABSS, the VEL group showed significantly greater improvement than the TVT group. In the odds ratio analysis for the 1-h pad test, no differences in any of the parameters were observed between TVT and VEL. VEL may be considered an alternative to TVT for SUI treatment.
Some algorithms for maximum volume and cross approximation of symmetric semidefinite matrices
Authors: Massei Stefano 
Published: April 2021

AbstractVarious applications in numerical linear algebra and computer science are related to selecting the $$r\times r$$

r
×
r

submatrix of maximum volume contained in a given matrix $$A\in \mathbb R^{n\times n}$$

A
∈

R

n
×
n

. We propose a new greedy algorithm of cost $$\mathcal O(n)$$

O
(
n
)

, for the case A symmetric positive semidefinite (SPSD) and we discuss its extension to related optimization problems such as the maximum ratio of volumes. In the second part of the paper we prove that any SPSD matrix admits a cross approximation built on a principal submatrix whose approximation error is bounded by $$(r+1)$$

(
r
+
1
)

times the error of the best rank r approximation in the nuclear norm. In the spirit of recent work by Cortinovis and Kressner we derive some deterministic algorithms, which are capable to retrieve a quasi optimal cross approximation with cost $$\mathcal O(n^3)$$

O
(

n
3

)

.