bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety among Pregnant Women about Corona Virus Infections during COVID-19 Pandemic at a Tertiary Care Center in Nepal: A Descriptive Cross-sectional Study
Authors: Shrestha Dipty , Saha Rachana , Manandhar Naresh , Adhikari Asmita , Dahal Jyoti 
Published: March 2021

Introduction: COVID-19 is a beta coronavirus that is transmitted by physical interaction or close contact. This Coronavirus Pandemic has also created stress and anxiety among pregnant women all over the world. The disease was first identified in Wuhan city, China, in late December 2019 and was declared pandemic by the World Health Organization on 11th March 2020. Concern and stress in pregnancy are associated with pre-eclampsia, intrauterine growth restriction, preterm labour, depression etc. Pregnancy is an immune-compromised state and poses a high risk to this risk. This study aims to identify anxiety about the coronavirus infection among pregnant women visiting a tertiary care centre in Kathmandu, Nepal, during this COVIDâ€“19 pandemic.
Methods: This is a descriptive cross-sectional study conducted at Kathmandu Medical College and Teaching Hospital from 15th July 2020 to 30th July 2020 after taking the ethical clearance from the Institutional Review Committee of Kathmandu Medical College (reference no. 207202002). Convenient sampling method was used. All the data were entered in Statistical Package for the Social Sciences data 20.0 and analyzed. Data was presented in frequencies, charts and percentage.
Results: Among the total 273 cases, only 2 (0.73%) cases had a score between 25-30 corresponding to moderate to severe anxiety, 21 (7.69%) had a score between 18-24, which corresponds to mild to moderate anxiety and 250 (91.57%) had score 0-17 which corresponds mild status.
Conclusions: Most of the participants in the study reported a mild status of anxiety. Very few participants reported moderate to severe anxiety.
Prevalence of Type 2 Diabetes among Patients Visiting Nepal Police Hospital in Kathmandu: A Descriptive Cross-sectional Study
Authors: Rajbhandari Bibek , Hyoju Sundar Prasad , Poudel Lisasha , Adhikari Anurag , Rijal Badri , Joshi Pramod 
Published: March 2021

Introduction: The growing prevalence of diabetes mellitus (DM) is a critical threat for global health,including in Nepal, especially in Kathmandu District, where diabetic patients are increasing in hospitals catastrophically. This study tends to assess the prevalence rate of type 2 diabetes among admitted patients visiting a hospital in Kathmandu.
Methods: An electronic chart review was done to assess the prevalence of type 2 diabetes in NepalPolice hospital, Kathmandu, Nepal. Ethical approval was taken from the Nepal Health ResearchCouncil. Considering eligibility criteria, 8631 cases from 4 May 2018 to 31 August 2020 wereobserved. The calculated sample size was 500. However, all diabetic cases, i.e., 576, were processedand analyzed using Python and later visualized using MS Excel.
Results: The overall prevalence rate of type 2 diabetes was 6.67%. The prevalence rate was seen higher among males (7.5%). Similarly, a high prevalence rate was seen among 64-73 years, i.e., 15.10%.
Conclusions: The findings showed a high prevalence rate of type 2 diabetes. Older age groups are athigh risk. Urgent public health interventions including lifestyle modification measures are requiredto reduce the extra burden of type 2 diabetes.
Acceptance of Vaginal Birth After Caesarean Section Trial in Shree Birendra Hospital, Kathmandu, Nepal: A Descriptive Cross-sectional Study
Authors: Khatri Ratna , Chand Arju , Thapa Manish , Thapa Sumana , Khadka Shailaja 
Published: March 2021

Introduction: The rate of primary cesarean section is on the rising trend. Vaginal birth after cesarean section can be an alternative to reduce cesarean section worldwide. Antenatal examination and intrapartum monitoring are the most important factors for a vaginal birth after a cesarean section. This study aims to determine the acceptance of vaginal birth after cesarean section trial in a tertiary care hospital in Nepal.
Methods: This is a descriptive cross-sectional study carried out in Shree Birendra Hospital, Kathmandu, Nepal, from March 2019 to March 2020. All pregnant women with a previous history of cesarean section meeting Royal College of Obstetrics and Gynecology criteria were included. A trial of labor was conducted on the patients who accepted vaginal birth after cesarean section.
Results: A total of 85 cases with previous lower section cesarean section were included in the study. Out of which, 75 (88.2%) refused vaginal birth after cesarean section, and only 10 cases (11.8%) accepted to undergo a trial of labor. Five women (50%) had a successful vaginal birth. Complications were less among the vaginal birth after cesarean section group than the repeat cesarean section group. There was no maternal and neonatal mortality.
Conclusions: The acceptance of vaginal birth after cesarean section is very low in this study. No complications were observed among vaginal birth after cesarean section in our study.
Status of Thyroid Disorder among the Thyroid Function Test Samples Received in a Laboratory among Postmenopausal Women: A Descriptive Cross-sectional Study
Authors: Shrestha Manoranjan , Shrestha Reshmi 
Published: March 2021

Introduction: Thyroid dysfunction prevalence is high in females worldwide which increases with age. Postmenopausal and elderly women are particularly at risk of developing comorbidities and mortality related to thyroid dysfunction. We aimed to study the prevalence of thyroid dysfunction in postmenopausal women in the National Reference Laboratory of Nepal.
Methods: A descriptive cross-sectional study was conducted in National Reference Laboratory from January 2019 to June 2019 including postmenopausal females, â‰¥49 years. The database of thyroid function test result was used for statistical analysis and proportion of thyroid dysfunction was calculated. The data was collected after approval from the institutional review committee. Statistical Package for Social Sciences version 21 was used to study descriptive data.
Results: Out of a total of 160 postmenopausal females with thyroid function tests, 71 (44.4%) had thyroid dysfunction. Subclinical hypothyroidism was the frequently occurring thyroid dysfunction 51 (32%) followed by subclinical hyperthyroidism 13 (8%), hypothyroidism 3 (2%) and hyperthyroidism 3 (2%). In our study population, thyroid dysfunction peaked at 49 to 58 years of age interval 53 (33.1%) and subclinical hypothyroidism was the most frequent form 38 (23.7%).
Conclusions: Subclinical hypothyroidism was the common thyroid dysfunction in postmenopausal age which peaked at 49 to 58 years of age group. Early postmenopausal females are predisposed to increased risk of comorbidities (cardiovascular disease, osteoporosis with high fracture, depression) which could be exacerbated with thyroid dysfunction; therefore awareness of thyroid dysfunction prevalence and thyroid screening for early management seems appropriate in Nepalese postmenopausal women.
Myalgic encephalomyelitis /chronic fatigue syndrome as a breakdown of homeostasis
Authors: Marks David F 
Published: March 2021

ME/CFS a multi-system, complex illness disabling millions of people worldwide. A new theory holds that ME/CFS is caused by a breakdown of homeostasis [https://www.scientificamerican.com/article/what-is-homeostasis/]. Homeostasis is a fundamental physiological principle that ensures equilibrium, stability and safety of the organism in a continuously changing and potentially life-threatening environment. A breakdown in homeostasis produces an aberrant state of disequilibrium with endocrinological and immunological changes consistent with the experienced disease symptoms.
Treatment harms to patients with ME/CFS
Authors: Marks David F 
Published: March 2021

Despite evidence of physiological and cellular abnormalities in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS), the dominant therapeutic approach has been cognitive behaviour therapy (CBT) and graded exercise therapy (GET). Patients report distress and dissatisfaction following healthcare encounters based on GET and CBT. A significant body of research suggests that CBT and GET are harmful for many patients with ME/CFS. These findings raise ethical concerns and suggest that more collaborative working between scientists, therapists and patients would be helpful in making scientific progress in this difficult field.
ANALISIS KUALITAS PELAYANAN TERHADAP TINGKAT KEPUASAN PENGGUNA RUANG TUNGGU PENUMPANG PELABUHAN TANJUNG PERAK DENGAN METODE SERVQUAL DAN TRIZ
Authors: Dirang Muhamad , Iriani Iriani 
Published: March 2021

Pelabuhan Tanjung Perak Surabaya, merupakan pelabuhan terbesar kedua setelah Pelabuhan Tanjung Priok. Dalam menjalankan fungsi dan tugasnya pelabuhan ini melayani terminal penumpang dan barang dan untuk memperoleh hasil yang optimal dan efisien diperlukan fasilitas penunjang. Penelitian ini dilakukan di Ruang tunggu pelabuhan tanjung perak Surabaya terhadap 84 responden dengan menggunakan metode servqual dan Triz
Namun dalam kenyataannya pihak pelabuhan sendiri mengalami berbagai permasalahan dalam memberikan layanan kepada para pengguna ruang tunggu,dibuktikan dengan berbagai keluhan dari 84 responden terhadap pelayanan diruang tunggu tersebut.
Berdasarkan permasalahan yang ada maka peneliti melakukan observasi pada ruang tunggu pelabuhan tanjung perak surabaya ini untuk mengetahui sejauh mana tingkat kualitas pelayanan yang diberikan dengan menerapkan metode Servqual, dan dari hasil penelitian menunjukkan bahwa tingkat kualitas pelayanan yang diberikan oleh pihak pelabuhan secara keseluruhan menunjukkan skor -1,42 yang mengindikasikan pihak pelabuhan belum bisa memenuhi harapan pengguna ruang tunggu dimana dari sebagian besar atribut layanan yang diteliti sebagian masih memiliki nilai negatif. Untuk menentukan solusi terbaik pada tiap atribut perbaikan kualitas pelayanan yang dirasa masih kurang, maka peneliti menerapkan metode 40 inventive principle TRIZ untuk menemukan langkah-langkah efektif dalam mewujudkan perbaikan kualitas layanan sesuai dengan kapasitas, dan kondisi pelabuhan yang ada saat ini.

Kata kunci: Servqual, harapan, persepsi pelanggan, 40 inventive principle TRIZ.
PENERAPAN METODE KANO DALAM ANALISIS KUALITAS PELAYANAN SISTEM PEMBELAJARAN BERBASIS ONLINE PADA PROGRAM STUDI TEKNIK INDUSTRI UPN “VETERAN” JAWA TIMUR
Authors: Ubaidillah Afiady Fitsal , Donoriyanto Dwi Sukma , Tranggono Tranggono 
Published: March 2021

Sistem pembelajaran yang terjadi di beberapa kampus umumnya masih menggunakan metode tradisional. Salah satu program studi teknik industri di Universitas Pembangunan Nasional “Veteran” Jawa Timur mengalami tingkat kualitas pelayanan yang menurun terhadap penggunaan metode pembelajaran berbasis online.di tengah maraknya sistem pembelajaran online. Dari segi kualitas belum pernah dilakukan analisa mengenai kepuasan mahasiswa dan dosen akan sistem pembelajaran berbasis online ini. Maka dari itu perlu dilakukan penelitian yang bertujuan untuk menganilisa kualitas pelayanan sistem pembelajaran berbasis online yang telah diberikan. Sehingga didapatkan saran perbaikan bagi perusahaan untuk meningkatkan kualitas pelayanannya. Penelitian dilakukan dengan menggunakan metode Servqual dan Kano kemudian dianalisa dalam bentuk matriks IPA dan tabel Kano. Hasil penelitian yang didapati berupa gap antara harapan dan kepuasan mahasiswa dan dosen akan sistem pembelajaran yang berlakus serta hal hal yang diprioritaskan untuk perbaikan berupa pengenalan lebih lanjut baik mahasiswa dan dosen untuk sistem pembelajaran online dan penambahan fitur fitur baru untuk sinkronisasi saat pembelajaran berlangsung sehingga apabila diterapkan maka akan tercipta upaya peningkatan kualitas pelayanan sistem pembelajaran berbasis onlene untuk program studi teknik industri UPN Veteran Jawa Timur.
Kata kunci : Sistem pembelajaran, Kualitas pelayanan,Servqual, Kano, Matriks IPA
EVALUASI EFEKTIVITAS LINI PRODUKSI BETON PRA-CETAK MENGGUNAKAN OVERALL EQUIPMENT EFFECTIVENESS (OEE)
Authors: Swara Suluh Elman , Novareza Oyong , Gita Sherenia Yuanggra 
Published: March 2021

PT. XYZ merupakan perusahaan industri penghasil beton pra-cetak di Indonesia dan Asia Tenggara yang memiliki 6 lini produksi untuk memproduksi beton pra-cetak. Penelitian ini dilakukan di lini produksi 2 karena memiliki downtime mesin yang tinggi dan defect yang berada diatas 1%. Oleh karena itu, perlu dilakukan pengukuran efektivitas menggunakan Overall Equipment Effectiveness (OEE). Berdasarkan hasil perhitungan, diketahui rata-rata nilai OEE sebesar 38.62% yang menunjukkan efektivitas dari lini produksi 2 masih rendah. Hal tersebut disebabkan oleh waktu siklus yang tidak memperhitungkan loading time, unloading time, dan waktu tunggu material, sehingga perlu melakukan penelitian waktu siklus menggunakan Stopwatch Time Study (STS) pada mesin Overhead Crane 1 (dari total 5 Overhead Crane) dan mesin Cor karena memiliki nilai OEE terendah. Penelitian STS menghasilkan perubahan waktu siklus mesin Overhead Crane menjadi 6,63 menit dan mesin Cor menjadi 10.2 menit sehingga terdapat peningkatan nilai OEE yaitu menjadi 40,8167% untuk mesin Overhead Crane dan 61,6871% untuk mesin Cor.
REPRESENTASI IMPERIALISME BUDAYA KOREA DALAM IKLAN NUTRISARI VERSI “JUNG MIN BUTUH VITAMIN”
Authors: M.B.P Ratu Laura , Wahyuningratna Ratu Nadya 
Published: March 2021

Istilah K-Pop dan K-Wave saat ini tidak asing lagi didengar. Kedua istilah tersebut sangat erat dengan kebudayaan Korea Selatan yang sedang menjamur tidak hanya di Indonesia namun juga di seluruh dunia. Dapat dipastikan saat ini semua orang dapat dengan mudah mengakses segala hal yang berhubungan dengan kebudayaan Korea Selatan melalui media cetak, elektronik maupun online. Dari drama, film, variety show maupun konser online dapat dinikmati di mana saja dan kapan saja tanpa Batasan waktu dan tempat. Tak hanya kaum remaja, anak-anak sampai dewasa mulai “teracuni” dengan hal-hal yang berbau Korea. Menurut Shim (2006) koreanisasi, adalah bentuk baru dari imperialisme budaya. Secara perlahan tapi pasti masyarakat di dunia tak lagi menjadikan budaya barat sebagai pusat dari segala budaya. K-Wave merupakan efek yang diinginkan dari strategi negara yang dirancang khusus untuk mengekspor produk-produk hiburan Korea ke luar negeri. Euphoria ini mulai dimanfaatkan oleh para pengiklan untuk memasukan unsur “berbau” Korea Selatan untuk menarik audiens. Salah satunya adalah Iklan Nutrisari versi “Jung Min Butuh Vitamin!” yang menggaet talent asli orang Korea untuk menarik perhatian. Peneliti tertarik untuk “membedah” iklan ini untuk mengetahui representasi imperialism budaya Korea Selatan yang dimunculkan menggunakan Semiotika Roland Barthes.
STRATEGI KOMUNIKASI HUMAS BIRO PEMBERITAAN DPR RI DALAM MENJAGA CITRA POSITIF ORGANISASI
Authors: Sidharta Veranus , Anisti Anisti , Arlena Wenny Maya , Azwar Azwar 
Published: March 2021

Artikel ini merupakan kajian atas strategi komunikasi humas Biro Pemberitaan DPR RI dalam menjaga reputasi dan citra positif organisasi. Hal penting yang mendasari penelitian ini adalah tidak kunjung baiknya citra DPR RI sebagai lembaga negara di mata masyarakat Indonesia. Selain kinerja DPR RI yang harus ditingatkan, tentu saja humas sebagai halaman depan lembaga, berperan besar dalam mengubah citra negatif ini menjadi citra positif. Penelitian ini akan melihat bagaimana peran Humas DPR RI dalam menjaga reputasi organisasi. Pelitian ini menggunakan metode kualitatif dimana peneliti melakukan kajian kepustakaan, observasi, dan wawancara mendalam terkait topik yang diteliti. Peneliti melakukan analisis PEST (Politik, Ekonomi, Sosial dan Teknologi) untuk melihat strategi komunikasi Humas Biro Pemberitaan DPR RI. Hasil penelitian ini menunjukkan bahwa intrumen politik legalitas DPR RI memuat wewenang dan fungsi sebagai lembaga penyelenggara negara dalam perencanaan program pembentukan dan perubahan Undang-Undang disusun secara terencana, terpadu, dan sistematis. Intrumen Ekonomi dan Sosial meliputi anggaran dan kebijakan ekonomi, dimana DPR RI membahas dan memberikan sebuah persetujuan atau tidak memberikan persetujuan terhadap sebuah rancangan undang-undang tentang APBN yang diajukan oleh presiden, serta faktor sosial mencakup aspek-aspek yang terkait dengan pemanfaatan media dalam penyebaran informasi kebijakan, layanan masyarakat dan progam berbagai event serta hubungan dengan media. Sedangkan faktor teknologi mencakup aspek-aspek teknologi informasi dan komunikasi berupa akses ketersediaan data dan informasi tentang program pemerintah tersediannya sistem dan jaringannya.Kata Kunci: strategi komunikasi, citra lembaga, analisis PEST
C-Reactive Protein Apheresis as Anti-inflammatory Therapy in Acute Myocardial Infarction: Results of the CAMI-1 Study
Authors: Ries Wolfgang , Torzewski Jan , Heigl Franz , Pfluecke Christian , Kelle Sebastian , Darius Harald , Ince Hueseyin , Mitzner Steffen , Nordbeck Peter , Butter Christian , Skarabis Horst , Sheriff Ahmed , Garlichs Christoph D. 
Published: March 2021

Background: C-reactive protein (CRP) is a well-known marker of inflammation. It is less known that CRP mediates tissue damage in acute myocardial infarction (AMI) thus potentially worsening prognosis. A newly developed specific CRP adsorber allows efficient lowering of CRP levels and may improve survival.Objectives: Aim of this multi-center, controlled, non-randomized first-in-man CRP apheresis in Acute Myocardial Infarction study (CAMI-1) was to investigate the relationship between CRP levels (CRP gradient), myocardial infarct size and function as well as safety and efficacy of CRP apheresis in the setting of acute ST-segment Elevation Myocardial Infarction (STEMI) in humans.Methods: Eighty-three patients (45 apheresis, 38 controls) were recruited. CRP apheresis was performed 24 ± 12, 48 ± 12, and optionally 72 ± 12 h after onset of symptoms. First aphereses were performed at a median CRP concentration of 23.0 mg/L (range 9–279). In each apheresis session, 5,900 ± 400 mL plasma was processed via peripheral venous access. Primary study endpoint was a reduction in myocardial infarct size after STEMI as determined by cardiovascular magnetic resonance (CMR).Results: In controls, the CRP concentration significantly correlated with infarct size (p = 0.002) and decreased myocardial function (p ≤ 0.001). The CRP concentration in apheresis patients did not correlate with infarct size (p = 0.66) or left ventricular (LV) function (p = 0.79) and global strains and therefore significantly differed from controls (p = 0.03 and p = 0.002). Three major adverse cardiac events occurred in the control group after 12 months, none occurred in the apheresis group. Mean CRP depletion achieved over all apheresis procedures was 53.0 ± 15.1%. Apheresis sessions were well-tolerated. Reduced infarct size in the apheresis group compared to the control group (primary endpoint) was not achieved according to the original statistical analysis plan. Taking into account the individual CRP levels, however, revealed significant results. Modifications of the analysis plan were introduced in order to recruit a sufficient number of patients.Conclusions: This pilot study in humans reveals a correlation between CRP concentration and myocardial infarct size. CRP concentrations in STEMI can effectively be reduced by CRP apheresis without relevant side effects. CRP apheresis has the potential to interfere with deleterious aspects of STEMI. By lowering CRP levels, it resulted in the loss of correlation of CRP concentrations with myocardial infarct sizes as well as LV function. These results encourage a larger, randomized clinical trial.Clinical Trial Registration:https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00008988, DRKS00008988.
Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review
Authors: Wells Georgia , Kennedy Paul T. , Dahal Lekh N. 
Published: March 2021

Background: The immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) facilitates tryptophan catabolism at the rate-limiting step of the kynurenine (Kyn) pathway. IDO expression and elevations in Kyn metabolites are associated with immunosuppressive tumor microenvironment including T cell proliferative arrest and generation of regulatory T cells (Tregs) which can favor tumor progression. However, the extent of the role of IDO in acute myeloid leukemia (AML) is currently ill-defined. This study reviews the role of IDO-driven Treg function in AML and evaluates the current body of evidence implicating IDO in AML pathogenesis.Method: Studies related to IDO in AML were identified through a systematic review of PubMed and Scopus. Data extracted described sample analysis, IDO expression, IDO in prognosis, techniques used in Treg phenotypic studies, and the effect of IDO inhibitors.Results: Twenty studies were included in the systematic review. Expression of IDO was identified in a range of cells in AML, both inducible and constitutive. Seven studies indicated an association between elevated expression and poor clinical prognosis. Six studies suggested a positive correlation between IDO expression and Treg induction, with FoxP3 being the prominent Treg phenotypic marker. Of eight studies investigating IDO inhibition, some reported reductions in Treg frequency and enhanced effector T cell proliferation.Conclusion: This review highlights that IDO expression in AML is associated with poor prognosis and measurement of IDO and its Kyn metabolites may offer utility as prospective prognostic markers. Pharmacological inhibition of IDO using novel drugs may hold promise for the treatment of AML.
Early Venous Filling Following Thrombectomy: Association With Hemorrhagic Transformation and Functional Outcome
Authors: Elands Sophie , Casimir Pierre , Bonnet Thomas , Mine Benjamin , Lubicz Boris , Sjøgård Martin , Ligot Noémie , Naeije Gilles 
Published: March 2021

Background and Purpose: Previous studies have noted the angiographic appearance of early venous filling (EVF) following recanalisation in acute ischemic stroke. However, the prognostic implications of EVF as a novel imaging biomarker remain unclear. We aimed to evaluate the correlation between EVF with (i) the risk of subsequent reperfusion hemorrhage (RPH) and (ii) the association of EVF on both the NIHSS score at 24 h and functional outcome as assessed with the Modified Rankin Scale (mRS) score at 90 days.Methods: We conducted a retrospective cohort study of patients presenting with an acute ischemic stroke due to a proximal large-vessel occlusion of the anterior circulation treated by thrombectomy. Post-reperfusion digital subtraction angiography was reviewed to look for EVF as evidenced by the contrast opacification of any cerebral vein before the late arterial phase.Results: EVF occurred in 22.4% of the 147 cases included. The presence of EVF significantly increased the risk of RPH (p = 0.0048), including the risk of symptomatic hemorrhage (p = 0.0052). The presence of EVF (p = 0.0016) and the absence of RPH (p = 0.0021) were independently associated with a better outcome as defined by the NIHSS difference at 24 h, most significantly in the EVF+RPH− group. No significant relationship was however found between either EVF or RPH and a mRS score ≤ 2 at 90 days.Conclusion: Early venous filling on angiographic imaging is a potential predictor of reperfusion hemorrhage. The absence of subsequent RPH in this sub-group is associated with better outcomes at 24 h post-thrombectomy than in those with RPH.