bluuebunny/crossref_metadata_2025_split huggingface dataset:
Original Article (Clinical Investigation) Enhanced Prediction of Renal Function Decline by Replacing Waist Circumference With “a Body Shape Index (Absi)” in Diagnosing Metabolic Syndrome: A Retrospective Cohort Study in Japan
Authors: Nagayama Daiji , Fujishiro Kentaro , Tsuda Shinichi , Watanabe Yasuhiro , Yamaguchi Takashi , Suzuki Kenji , Saiki Atsuhito , Shirai Kohji 
Published: August 2021

Abstract
Background: Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is conventionally evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. We aimed to examine whether replacing WC with “A Body Shape Index (ABSI)”, an abdominal obesity index, in MetS diagnosis is useful for predicting renal function decline (RFD). Methods: A retrospective cohort study was conducted in 5438 Japanese urban residents (median age 48 years) who participated in a public health screening program for 4 consecutive years. Systemic arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and high CAVI was defined as CAVI ≥ 9.0. The predictability of the occurrence of RFD (eGFR < 60 mL/min/1.73m 2 ) by replacing high WC with high ABSI (ABSI ≥ 0.080) was examined using three sets of MetS diagnostic criteria: Japanese, International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Results: In Japanese and NCEP-ATPIII criteria, MetS diagnosed using ABSI (ABSI-MetS) was associated with significantly higher age-adjusted CAVI compared to non-MetS, whereas MetS diagnosed using WC (WC-MetS) showed no association. Kaplan-Meier analysis of the rate of new-onset RFD over 4 years (total 8.7%) showed remarkable higher rate in subjects with ABSIMetS than in those without (log-rank test p <0.001), but almost no difference between subjects with and without WC-MetS ( p = 0.014-0.617). In Cox analysis including gender, high CAVI and low-density lipoprotein‒cholesterol ≥140 mg/dL as confounders, only ABSI-MetS diagnosed by Japanese criteria contributed independently to the occurrence of RFD (HR = 1.41, p = 0.011). High CAVI was also an independent contributor to the occurrence of RFD. In a subanalysis, ABSI-MetS diagnosed by Japanese criteria contributed significantly to the occurrence of RFD regardless of age or gender, while WC-MetS by Japanese criteria contributed significantly only in older women. Conclusion: In this study, replacing WC with ABSI in MetS diagnostic criteria more efficiently predicted subjects at risk of RFD and arterial stiffening. Further studies are needed to confirm whether MetS diagnosed using ABSI also predicts CVD.
Evidence of Climate Change Impact on Parkinson’s Disease
Authors: Buizza Roberto , Carratore Renata Del , Bongioanni Paolo 
Published: August 2021

Abstract
We have investigated the link between climate change and Parkinson’s diseases (PD) by contrasting variations between 1990 and 2016 of PD patients’ indices (prevalence, deaths, and disability-adjusted life years) and climate indices (warming and annual average temperature) for 185 countries. Countries have been clustered in four categories, depending on whether they had higher-than-median warming and higher-than-median temperature, and for each cluster variations in PD patients’ and climate indices have been studied. In the cluster of the 25 countries (home to about 900 million people) characterized by higher-than-average warming and higher-than-average temperature, we have found evidence of a correlation between more intense warming and higher variations. This statistical result is discussed and linked to other evidence reported in literature. To our knowledge, this is the first time that a statistically-sound link between climate change and the epidemiological data of PD patients has been found and documented.
A Customized Mask Retainer and Its Effects on Improving the Fit Performance of Surgical Masks
Authors: Chen Xi , Xi Qi , Lu Wei , Sun Fangfang , Wang Lirong , Zhang Li , Wu Guofeng 
Published: August 2021

Abstract
Background: With the outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the effectiveness of providing mask protection is important for people. This article introduces a customized mask retainer to improve the fit performance of face masks.Methods: The participant’s 3D face scans with and without a surgical mask were taken by using a 3D face scanner. The fitter was designed on the 3D face scan data according to the facial anthropometric landmarks, and examined and adjusted on the face scan data with a mask. The fitter was 3D printed using a metal printer for Titanium. The effectiveness of the fitter on augmentation of fit of surgical mask was test according to the Chinese Standard. Tests were repeated three times per participant, and compare differences between groups by Wilcoxon Matched-Pairs Signed-Ranks Test using software (a=.05).Results: The effectiveness test of the retainer on augmentation of fit performance showed a result more than 25-fold increase of overall Fit Factor, which have met the fit requirement for KN95 respirators in China.Conclusions: Fit Factor results indicated that by using the retainer, the Fit Factors of overall and each exercise have significantly increased as compared to that of face mask alone group. It may provide a solution to the shortage of N95 respirators the world is now encountering as fighting against the COVID-19 epidemic.
Prenatal Diagnosis of Complete Paternal Uniparental Isodisomy for Chromosome 3: A Case Report
Authors: bu xiufen , Li Xu , Zhou Shihao , Shi Liangcheng , Jiang Xuanyu , Peng Can , Li Hongyu , He Jun 
Published: August 2021

Abstract
Background Paternal uniparental disomy (UPD) of chromosome 3 is a very rare condition. At present, only 5 cases of paternal UPD(3) has been reported. This was the second ascertained paternal UPD(3) with no apparent disease phenotype.Case presentation We hereby reported a case of a fetus with normal karyotype and normal ultrasound features at the whole gestation. A copy neutral regions of homozygosity on chromosome 3 was indentified by Single Nucleotide Polymophism array (SNP array). Subsequent SNP array data of parent–child trios showed the fetus has carried complete paternal uniparental isodisomy (isoUPD) of chromosome 3. The parents decided to continue the pregnancy after genetic counseling. The neonate had normal physical findings at birth and develops normally after 1.5 years. Conclusions The findings could provide further evidence to confirm that there was no important imprinted genes causing serious diseases on paternal chromosome 3 and provided a reference for the prenatal diagnosis and genetic counseling of UPD(3) in the future.
Study on the Kinematic characteristics of different level jumpers squatting and jumping under different ground
Authors: Hewehn Hua 
Published: August 2021

Abstract
Objective: The purpose of this study is to compare the kinematic differences of different level jumping athletes in the process of squatting on different ground, and to reveal the photomechanical mechanism of the effect of squatting on the different ground on training effect.Methods: The subjects were 11 first-class and above jumping athletes (excellent group) and 11 second-class athletes (ordinary group). The kinematic data were photographed by SONYDCRHC52E high-speed camera with a sampling frequency of 50 frames per second, and the data were analyzed by SIMI-Motion three-dimensional motion analysis system. Subjects squatted and jumped on four kinds of ground (force platform, balance pad, gymnastics pad, and sand) with their hands on their hips.Results: In the intra-group analysis, it was found that the athletes of different levels squatted and jumped on four different kinds of ground, but there was no significant difference only on the balance pad and gymnastics mat (excellent group p=0.344, ordinary group p=1). In the inter-group analysis, it was found that there were significant differences between different levels of athletes in balance pad (p=0.043) and sand (p=0.02). In the buffering stage of the squatting jump, there was no significant difference in the buffering angle displacement of lower limb joints of different athletes on different ground. In the stage of pedal and extension, the angular displacement of the ankle on the middle platform of the excellent group was significantly different from that of the balance pad (p=0.014), gymnastics pad (p=0.017), and sand (p=0.013), but in the ordinary group, the ankle angular displacement of the middle platform was only significantly different from that of the gymnastics pad (p= 0.048) and sand (p=0.017), but not significantly different from that of the balance pad (p=0.166). The maximum angular velocity of the hip joint of athletes of different levels was significantly different among different ground groups. The maximum angular velocity of the ankle joint of the common group was significantly different in force platform and sand (p=0.032), gymnastics ma,t and sand (p=0.008), but there was no significant difference in balance pad.Conclusion: Different places have a great influence on the ordinary group, and on the ground with lower elastic coefficient, the maximum angular velocity of the ankle joint in the ordinary group is much smaller than that in the excellent group, which indicates that the rapid contractile ability of ankle muscles in the ordinary group is poor on the ground with low elastic coefficient. When squatting and jumping on the ground with a lower elastic coefficient, the excellent group has better body control and coordination and lower joint energy loss, which makes the jumping effect better, while the ordinary group squats and jumps on the ground with a low elastic coefficient and unstable ground. The jumping effect is poor.
Molecular Dynamics of SARS-CoV-2 Nsp1 Structural Changes Associated with Variant Mutations
Authors: Rezaei Shokouh , Sefidbakht Yahya , Pereira Filipe 
Published: August 2021

Abstract
SARS-CoV-2 non-structural protein 1 (Nsp1) is a virulence factor that inhibits the translation of host mRNAs and interact with viral RNA. Despite the relevance of Nsp1, few studies have been conducted to understand the effect of mutations on Nsp1 structure and function. Here, we provide a molecular dynamics simulation of SARS-CoV-2 Nsp1, wild type and variants. We found that SARS-CoV-2 Nsp1 has a more Rg value than SARS-CoV-1 Nsp1, with indicate an effect on the folding protein. This result suggest that SARS-CoV-2 Nsp1 can more easily approach the active site of the ribosome compared to SARS-CoV-1 Nsp1. In addition, we found that the C-terminal of the SARS-CoV-2 Nsp1, in particular residues 164 to 170, are more flexible than other regions of SARS-CoV-2 Nsp1 and SARS-CoV-1 Nsp1, confirming the role of this region in the interaction with the 40S subunit. Moreover, multiple deletion mutations have been found in the N/C-terminal of the SARS-CoV-2 Nsp1, which seems the effect of SARS-CoV-2 Nsp1 multiple deletions is greater than that of substitutions. Among all deletions, D156-158 and D80-90 may destabilize the protein structure and possibly increase the virulence of the SARS-CoV-2. Overall, our findings reinforce the importance of studying Nsp1 conformational changes in new variants and its effect on virulence of SARS-CoV-2.
Removal of Lead From Aqueous Solutions Using Three Biosorbents of Aquatic Origin: Evaluating the Relative Roles of Factors Affecting the Biosorption Process
Authors: Rezaei Maryam , Pourang Nima , Moradi Ali Mashinchian 
Published: August 2021

Abstract
The biosorptive potentials of three aquatics-based biosorbents, including shells of a bivalve mollusk and scales of two fish species for Pb removal from aqueous solutions were evaluated, for the first time. A Box–Behnken design with the response surface methodology was used to investigate the effects of the seven important variables (contact time, temperature, initial concentration, dosage, size, salinity and pH) on the sorption capacity of the sorbents. Among the seven studied factors, the effects of biosorbent dosage, initial concentration and pH were significant for all the response variables, while biosorbent size was not significant for any of the responses. The initial concentration was the most influential factor. The presence of Pb ions on the surfaces of the biosorbents after the adsorption was clearly confirmed by the SEM-EDX and XRF analyses. The maximum sorption capacities of the biosorbents were comparable to the literature and the descending order was as follows: scales of Rutilus kutum and Oncorhynchus mykiss and the shells of Cerastoderma glaucum. The isotherm studies revealed Langmuir model applicability for the Pb adsorption by R. kutum scales and C. glaucum shells, while Freundlich model was fitted to the adsorption by O. mykiss scales.
Does Neighborhood Status Affect Access to a Healthy Built Environment?
Authors: Goheer Amina , Pomeroy-Stevens Amanda , Mishra Neeraj , Krishnan Anand , Armarchand Ritvik , Bachani Damodar 
Published: August 2021

Abstract
Background: When looking to better understand the links between income and health, urban settings add an additional dimension of structural inequity. Without proactive urban planning, some neighborhoods are deprived of essential services, while other neighborhoods enjoy easier access to services and providers. The case of Indore, India was used to explore differentials in available services, infrastructure, and access to goods and services relating to non-communicable disease risk when the data was disaggregated by neighborhood type (slum vs non-slum). Methods: The environmental data for this paper came from a city-wide multi-level survey conducted in 2018, which included a neighborhood environmental assessment tool adapted from pre-validated questionnaires. Wards were randomly selected using a probability proportional to size (PPS) method after stratification by presence of slums. Within each ward, three colonies were then selected by PPS. The environmental data were collected from the same 30 wards and 93% (84/90) of the same colonies as the individual data. Results: The analysis highlighted some expected inequalities by neighborhood status, such as neighborhoods with no parks (62% slum vs 31% in non-slum). In neighborhoods where parks were present, there appeared to be issues with safety within the parks. Regarding walkability, slum neighborhoods generally had a higher prevalence of broken glass, liquor bottles, and stray dogs on footpaths. Non-slum neighborhoods had, on average, more vegetable stores, while slum neighborhoods had more snack and tobacco stores. The ratio of pro-tobacco versus anti-tobacco ads was twice as bad in slums than in non-slums. Conclusion: Better understanding of the access and availability of green spaces, transportation, and food markets between neighborhoods will help local officials, developers, and citizens as they formulate more equitable ways to distribute resources to build healthier environments for all citizens.
The Influence of Inherent Soil Factors And Agricultural Management On Soil Organic Matter
Authors: Richardson Gregory S. , Ruark Matthew D. , Radatz Timothy , Radatz Amber , Cooley Eric , Silva Erin M. , Augarten Abigail J , Zhu Jun , Zegler Chelsea H. 
Published: August 2021

Abstract
The accumulation of soil organic matter (SOM) is vital to the agronomic and environmental functioning of agroecosystems, yet the relative influence of inherent soil properties and agricultural management practices on SOM dynamics are not often addressed in individual studies. Using a network of 218 operating farm fields across Wisconsin and southern Minnesota, USA, this research employs single variable analysis (ANOVA and regression) and regression tree analysis to assess the effects of soil properties (texture, drainage class, pH) and management variables related to crop rotation, tillage, cover cropping, and manure application on SOM, as well as total organic carbon (TOC) and total nitrogen (TN) in the upper 15 cm. Single variable analysis revealed that greater SOM, TOC, and TN were associated with poorly drained soil, tile drained fields, high-clay content soil, and high biomass crop rotations. Soil organic matter (SOM) and TOC were strongly related (R2=0.71), but different regression trees were produced; SOM was most influenced by clay content, while TOC was most influenced by drainage class. Future benchmarking of SOM should be conducted with drainage and texture class categories. The rapid building of data sets thorough unstructured sampling, including an abundance of meta-data, should be a research priority in agricultural science.
Biosynthesis and Characterization of Zinc Oxide Nanoparticles Using Leaf Extract of Phoenix Dactylifera and Their Impact on Biomass and Bioactive Compounds in Juniperus Procera in Vitro
Authors: Salih Abdalrhaman , Qurainy Fahad Al , Khan Salim , Tarroum Mohamed , Nadeem Mohammad , Shaikhaldein Hassan , Gaafar Abdel-Rhman , Alfarraj Norah 
Published: August 2021

Abstract
Biosynthesized nanoparticles have played vital role recently, as suggested to be alternative to physical and chemical methods. In this study, biosynthesis of zinc oxide nanoparticles (ZnO NPs) were carried out using leaf extracts of Phoenix dactylifera and Zinc nitrate. The effect of ZnO nanoparticles on biomass and biochemical parameters was investigated. Biosynthesized ZnO nanostructure was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), UV–visible spectrophotometer and Fourier transform infrared spectroscopy (FTIR). Which resulted in spherical shape with size ranging between 16 to 35 nm of Biosynthesized ZnO nanoparticles and UV absorption beak at 370.5 nm with clear peaks of functional groups. The impact of different concentrations (0.0 mg/L, 80 mg/L and 160 mg/L) of biosynthesized ZnO nanoparticles on biomass and bioactive compounds production of Juniperus Procera in vitro was investigated. The results showed that, biosynthesized ZnO NPs (80 mg /L and 160 mg/L) concentrations were boosted the growth of J. Procera with significantly compared to non-treated plants in vitro. The highest concentration (160mg/L) of ZnO NPs was enhanced the growth of plant at beginning period, one month later shoots became yellow and callus turned to be brownish. Moreover, the influence of ZnO NPs on phytochemical compounds in callus of Juniperus procera was examined using GC-MS analysis. The differences among treatments were recoded. Overall, zinc oxide nanoparticles substantially improved the growth of shoots and callus with increasing of biochemical parameters such as chlorophyll a, total phenolic and flavonoids contents, besides the total protein and, SOD, CAT and APX activity. ZnO NPs might be induced some phytochemical compounds as well as inhibit.
New Predictive Models for Falls in Acute Care Setting Classified Using An Activities of Daily Living Scale in Japan: A Retrospective Cohort Study
Authors: Saito Chihiro , Nakatani Eiji , Sato Yoko , Katuki Naoko , Tago Masaki , Okushio Kazuyo , Unno Satomi , Yumioka Motoe , Harada Kiyoshi 
Published: August 2021

Abstract
Background

In several current fall prediction models, the reported predictors vary from one model to another. We developed and validated a new fall prediction model for patients admitted to an acute care hospital by identifying predictors of falls considering a combination of background factors and one crucial stratum.
Methods

We conducted a retrospective cohort study of patients admitted to Shizuoka General Hospital from April 2019 to September 2020, aged 20 years or older. We developed and validated a new fall prediction model by identifying predictors of falls stratified by essential activities of daily living (ADL) indicators and integrating these models.
Results

A total of 22,988 individuals were included in the analysis, with 653 (2.8 %) experiencing all falls and 400 (1.7 %) experiencing falls with medical resources during the study period. Multivariate analysis was performed after one stratification level, using bedridden rank (ability to move around in daily life) as a stratifying variable, a clinically important variable and highly correlated with 17 other variables. The results of multivariate analysis showed that the risk factors for falls (high risk) were age (high), sex (men), and ambulance transport (yes) for rank J (independence/autonomy); age (high),) and sex (men) for rank A (house-bound); There were no predictors for rank B (chair-bound); and there was ophthalmologic disease (no) for rank C (bed-bound). The c-index indicating the prediction model’s performance for falls within 28 days of hospitalisation was 0.705 (95 % CI, 0.664–0.746). Hosmer-Lemeshow goodness-of-fit statistics were significant (χ2 = 192.06; 8 degrees of freedom; p < 0.001). The c-index for the entire unstratified sample was 0.703 (95 % CI, 0.661–0.746), indicating that the predictive model stratified by bedriddenness rank was accurate (p < 0.001).
Conclusion

We identified predictors of falls using important ADLs (bedriddenness rank) and developed a more accurate prediction model in acute care hospital settings. This predictive model is an essential tool for fall prevention.
The Dose-Response Relationship between The triglyceride-glucose index and Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal Study in Chinese Obesity adult population
Authors: he jiacheng 
Published: August 2021

Abstract
BackgroundTriglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Obesity population. The purpose of this study was to evaluate the correlation between TyG index and the risk of incident T2DM in Chinese Obesity adult population.Methods80,919 participants with BMI≥ 24 were selected from a prospective cohort study data which was collected between 2010 and 2016 across 32 sites and 11 cities in China.The risk of incident T2DM according to TyG index was estimated using multivariable Cox proportional hazards models and a two-piece wise linear regression model was developed to find out the threshold effect.The formula for TyG index was expressed as ln[fasting triglyceride leve (mg/dL)× fasting plasma glucose level(mg/dL)/2].ResultsAfter follow-up, 3008 ( 3.7%) patients developed T2DM. After adjusting for potential confounders, as a continuous variable, TyG index was associated with an increased risk of incident T2DM (adjusted hazard ratio (aHR), 3.81; 95% confidence interval (95% CI), 3.56-4.09.Further analysis revealed a positive curvilinear association between TyG index and incident T2DM, with a saturation effect predicted at 9.328. When the TyG index was less than 9.328, the risk of incident T2DM increased significantly[HR 4.778 (4.149,5.462), P< 0.001], while the risk became gentle when beyond 9.328[HR 2.61 (2.123,3.209), P< 0.001]. Subgroup analyses showed that the association between TyG index and incident T2DM stably existed in different subgroups.ConclusionsTyG index was a significant predictor of subsequent risk of incident T2DM in Chinese Obesity adult population. An increase in TyG index of one unit increased the risk of developing T2DM by 3.81-fold.