bluuebunny/crossref_metadata_2025_split huggingface dataset:
POLIGAMI/POLIGINI PERSPEKTIF HUKUM ISLAM
Authors: Mas'ud Muhamad , Abdurrahman Asep , Al-Fahmi Faiz Fikri 
Published: March 2021

AbstractMarriage is formed to create a harmonious, happy, and prosperous family (sakinah, mawaddah, and rahmah). Polygyny or better known as polygamy has always been a subject of fiqh which has always been excellent among fiqh experts and researchers of Islamic law. This form of polygamy is well known among medes, babylonia, abyssinia, and Persians. The Prophet Muhammad allowed polygamy among his people because it was also practiced by the Greeks, among whom even a wife could not only be exchanged but could also be traded commonly among them. Australia and Mormons in America. Even Hinduism in India does not prohibit polygamy. The jahiliyyah Arabs married a number of women and regarded them as possessions, even in large part, especially as they were not part of a marriage because the women could be brought, owned and sold as they pleased. Polygamy becomes an emergency exit for a husband who has been established in household mahligai as a protection against adultery. AbstrakPerkawinan dibentuk untuk menciptakan keluarga yang bernuansa harmonis, bahagia, dan sejahtera, (sakinah, mawaddah, dan rahmah). Poligini atau lebih dikenal dengan istilah poligami senantiasa menjadi bahasan fiqih yang selalu menjadi primadona dikalangan para ahli fiqih dan para peneliti hukum Islam. Bentuk poligami telah dikenal diantara orang-orang medes, babilonia, abesinia, dan Persia. Nabi Muhammad SAW membolehkan poligami diantara masyarakatnya karena telah dipraktekkan juga oleh orang-orang yunani yang diantaranya bahkan seorang istri bukan hanya dapat dipertukarkan tetapi juga dapat diperjual belikan secara lazim diantara mereka. Australia serta mormon di Amerika. Bahkan ajaran hindu di India tidak melarang poligami. Orang-orang arab jahiliyyah menikahi sejumlah wanita dan menganggap mereka sebagai barang kepunyaan bahkan dalam sebagian besar khususnya ia bukanlah bagian perkawinan karena para wanita itu dapat dibawa, dimiliki, dan dijual sekehendaknya. Poligami menjadi sebuah emergency exit bagi seorang suami yang telah mapan dalam mahligai rumah tangga sebagai proteksi terhadap perbuatan perzinaan.
KAIDAH PENAFSIRAN MENURUT MUHAMMAD JAMAL AL-DIN AL-QASIMI
Authors: Haromaini Ahmad 
Published: March 2021

Tafsir merupakan produk teks dari sumber teks al-Qur’an. Kehadiran tafsir sangat dibutuhkan dalam menjelaskan petunjuk-petunjuk al-Qur’an. Namun apakah penafsiran yang dilakukan sudah sesuai dengan ketentuan kaidah penafsiran? Lalu apakah setiap ulama tafsir menuliskan kaidah penafsiran sebelum menafsirkan al-Qur’an di kitab tafsirnya? Ulama kontemporer seperti Muhammad Jamal al-Din al-Qasimi sebelum memulai penafsiran al-Qur’an, terlebih dulu menjelaskan beberapa kaidah penafsiran yang harus dipenuhi bagi mereka yang ingin menafsirkan al-Qur’an. Penelitian ini menggunakan metode penelitian kualitatif dengan mengolah data dari kitab Tafsir Mahasin al-Ta’wil karya Muhammad Jamal al-Din al-Qasimi sebagai data primer dan kitab-kitab tafsir lain sebagai data sekunder. Dari hasil penelitian ditemukan bahwa kaidah penafsiran oleh Muhammad Jamal al-Din al-Qasimi dibagi menjadi qawa’id fi makhaidz tafsir dan kaidah memilih tafsir yang shahih dan yang paling shahih. Kaidah yang pertama Al-Qasimi didasari dari kaidah-kaidah penafsiran yang ditulis Jalal al-Din al-Suyuti dalam kitab al-Itqan fi ‘Ulum al-Qur’an
ANALISIS BEBAN KERJA FISIOLOGIS MAHASISWA SAAT PRAKTIKUM ANALISA PERANCANGAN KERJA DENGAN MENGGUNAKAN METODE 10 DENYUT
Authors: Rahayu Monita 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui beban kerja fisiologis pada mahasiswa saat melakukan praktikum Analisa Perancangan Kerja Program Studi Teknik Industri Fakultas Teknik Universitas Islam Syekh-Yusuf. Pengukuran denyut nadi merupakan salah satu cara untuk mengetahui beban kerja seseorang. Metode yang digunakan adalah metode 10 denyut. Dalam penelitian ini terdapat sampel sebanyak 6 orang mahasiswa yang akan diukur denyut nadi saat beraktivitas dan saat istirahat saat melakukan praktikum. Selain itu juga dihitung HR reverse, %CVL, konsumsi energi serta waktu istirahat. Dari hasil penelitian berdasarkan %CVL berada pada kategori tidak terjadi kelelahan sedangkan dari jumlah konsumsi energi rata-rata mahasiswa berada pada kategori ringan.Kata Kunci : beban kerja, denyut nadi, %CVL
Analisis Beton Ringan Dengan Penambahan Batu Apung Dan Zat Additive Untuk Pengujian Kuat Tekan Beton
Authors: Basid Abdul 
Published: March 2021

Beton ringan merupakan material penting dan diminati sehingga saat ini telah diaplikasikan pada struktur bangunan dan jembatan. Beton ringan mempunyai keuntungan ekonomi jika dibandingkan beton agregat normal, meskipun biaya per volume beton lebih tinggi tetapi karena beratnya yang lebih ringan menyebabkan pengurangan dimensi struktur sehingga secara keseluruhan akan memberikan biaya yang rendah. Penambahan batu apung yang dijadikan agregat ringan dalam pembuatan beton ringan dengan penambahan zat additive penta 003 dan juga agent foam dapat mempengaruhi terhadap berat jenis beton tersebut sesuai SNI 03-2847-2002 (Beton ringan adalah beton yang mempunyai berat satuan tidak lebih dari 1900 kg/m3). Didapati berat jenis 1m3 sebesar 1772,6 kg/m3 . Dari hasil penelitan beton normal yang dibandingkan dengan beton ringan memiliki perbandingan berat jenis 1m3 sebesar 458,4 kg/m3 , hal ini menjelaskan bahwa batu apung yang dijadikan agregat halus dapat dijadikan bahan dasar untuk pembuatan beton ringan. Pada pengujian kuat tekan beton ringan didapati peningkatan dalam kuat tekan beton pada umur 7 hari ke 14 hari sebesar 26,77% , lalu umur 14 ke 28 hari sebesar 20,21% dan yang terakhir perbandingan pada umur 7 hari ke 28 hari memiliki kuat tekan 41,72%.Kata kunci: Beton ringan, breksi batu apung, kuat tekan, zat additive
Origins of the African Offshore Oil and Gas Cooperation Milestone: The Nigeria – São Tomé & Principe Regime
Authors: Ferrara Pablo 
Published: March 2021

This paper aims at identifying and explaining the design principles of the joint development regime between Nigeria and São Tomé & Principe, analysing the subsequent dynamics – the nature of cooperation – generated by the regime's design. In order to fulfil its objectives, it shall start by explaining the applicable socio-legal research methodology, then continue with the analysis of the case study, finishing with the relevant conclusions. Characterized by large oil reserves, low development capacity, international oil companies appetite, and corrupt governments, this work depicts Nigeria and São Tomé e Príncipe as large oil reservists with potential but low development capacity, resulting in a dyad of international oil companies keen on offshore development and corrupt governments looking to exploit it. On the other hand, recognition of the offshore development potential in their overlapping claim zone and international oil companies’ pressured the States to improve their political governance, developing on both countries the decision to achieve an international development regime (JDZ) proven profitable for both countries in many ways – not only economic.
OPCML Methylation and the Risk of Ovarian Cancer: A Meta and Bioinformatics Analysis
Authors: Shao Yang , Kong Jing , Xu Hanzi , Wu Xiaoli , Cao YuePeng , Li Weijian , Han Jing , Li Dake , Xie Kaipeng , Wu Jiangping 
Published: March 2021

Background: The association of opioid binding protein cell adhesion molecule-like (OPCML) gene methylation with ovarian cancer risk remains unclear.Methods: We identified eligible studies by searching the PubMed, Web of Science, ScienceDirect, and Wanfang databases. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to determine the association of OPCML methylation with ovarian cancer risk. Meta-regression and subgroup analysis were used to assess the sources of heterogeneity. Additionally, we analyzed the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets to validate our findings.Results: Our study included 476 ovarian cancer patients and 385 controls from eight eligible studies. The pooled OR was 33.47 (95% CI = 12.43–90.16) in the cancer group vs. the control group under the random-effects model. The association was still significant in subgroups according to sample type, control type, methods, and sample sizes (all P &lt; 0.05). Sensitivity analysis showed that the finding was robust. No publication bias was observed in Begg's (P = 0.458) and Egger's tests (P = 0.261). We further found that OPCML methylation was related to III/IV (OR = 4.20, 95% CI = 1.59–11.14) and poorly differentiated grade (OR = 4.37; 95% CI = 1.14–16.78). Based on GSE146552 and GSE155760, we validated that three CpG sites (cg16639665, cg23236270, cg15964611) in OPCML promoter region were significantly higher in cancer tissues compared to normal tissues. However, we did not observe the associations of OPCML methylation with clinicopathological parameters and overall survival based on TCGA ovarian cancer data.Conclusion: Our findings support that OPCML methylation is associated with an increased risk of ovarian cancer.
The Association of TLR2, TLR3, and TLR9 Gene Polymorphisms With Susceptibility to Talaromycosis Among Han Chinese AIDS Patients in Guangdong
Authors: Wang Min , Li Linghua , Xiao Saiyin , Chen Wanshan , Hu Fengyu , Li Feng , Guo Pengle , Chen Xiejie , Cai Weiping , Tang Xiaoping 
Published: March 2021

BackgroundTalaromycosis (TM) caused by Talaromyces marneffei (T. marneffei) is a growing public health concern. Although Toll-like receptor (TLR) genes play a critical role in the host defense against fungal infection, the influence of polymorphisms in these genes on the susceptibility of acquired immune deficiency syndrome (AIDS) patients to TM remains unknown. This study aims to uncover the associations of single nucleotide polymorphisms (SNPs) in TLR genes with TM susceptibility among patients with AIDS.MethodsAltogether 200 AIDS patients complicated with TM, 200 matched AIDS patients without TM, and 76 healthy controls (HCs) were enrolled in this case-control study. In total, 23 SNPs in the TLR2, TLR4, and TLR9 genes, which may influence the susceptibility of AIDS patients to TM, were checked by the time of flight mass spectrometry (TOF/MS) method among these Han Chinese subjects.ResultsNo significant differences in genotype or allele frequencies of selected SNPs were found among the TM group, Non-TM group, and HC group. Haplotype analysis also demonstrated no correlation of these SNPs with TM. However, subgroup analysis showed that the genotype TT and the T allele in TLR2 SNP rs1339 were more frequent in typical TM cases than controls (50.0 vs. 35.8%, 70.5 vs. 59.7%); the frequency of the GT genotype in TLR2 SNP rs7656411 was markedly higher in severe TM cases compared to controls (57.8 vs. 34.4%).ConclusionOur results demonstrate a genetic connection of TLR2 SNPs rs1339 and rs7656411 with an increased susceptibility and severity of TM among Han Chinese populations.
Reduced Albumin Concentration Predicts Weight Gain and Higher Ad Libitum Energy Intake in Humans
Authors: Basolo Alessio , Ando Takafumi , Chang Douglas C. , Hollstein Tim , Krakoff Jonathan , Piaggi Paolo , Votruba Susanne 
Published: March 2021

ObjectiveCirculating albumin is negatively associated with adiposity but whether it is associated with increased energy intake, lower energy expenditure or weight gain has not been examined.MethodsIn study 1 (n=238; 146 men), we evaluated whether fasting albumin concentration was associated with 24-h energy expenditure and ad libitum energy intake. In study 2 (n=325;167 men), we evaluated the association between plasma albumin and change in weight and body composition.ResultsAfter adjustment for known determinants of energy intake lower plasma albumin concentration was associated with greater total daily energy intake (β= 89.8 kcal/day per 0.1 g/dl difference in plasma albumin, p=0.0047). No associations were observed between plasma albumin concentrations and 24-h energy expenditure or 24-h respiratory quotient (p&gt;0.2). Over 6 years, volunteers gained on average 7.5 ± 11.7 kg (p&lt;0.0001). Lower albumin concentrations were associated with greater weight [β=3.53 kg, p=0.039 (adjusted for age, sex, follow up time), CI 0.16 to 6.21 per 1 g/dl difference albumin concentration] and fat mass (β=2.3 kg, p=0.022), respectively, but not with changes in fat free mass (p=0.06).ConclusionsLower albumin concentrations were associated with increased ad libitum food intake and weight gain, indicating albumin as a marker of energy intake regulation.Clinical Trial RegistrationClinicalTrials.gov, identifiers NCT00340132, NCT00342732.
Effect of Tissue-Selective Estrogen Complex on Hip Structural Geometry in Postmenopausal Women: A 12-Month Study
Authors: Kim Bo Mi , Kim Sung Eun , Lee Dong-Yun , Choi DooSeok 
Published: March 2021

BackgroundHip structural analysis (HSA) is a method for evaluating bone geometry reflecting bone structural and biomechanical properties. However, tissue-selective estrogen complex (TSEC) treatment effects on HSA have not been investigated.ObjectiveThis study was performed to evaluate the effect of TSEC treatment on hip geometry in postmenopausal Korean women. The treatment was given for 12 months, and hip geometry was measured by HSA.Materials and MethodsA total of 40 postmenopausal women who received TSEC containing conjugated estrogen 0.45 mg and bazedoxifene 20 mg for treating vasomotor symptoms were included in this retrospective cohort study. The changes in bone mineral density and parameters of HSA including the outer diameter, cross-sectional area, cross-sectional moment of inertia, cortical thickness, section modulus, and buckling ratio as determined by dual-energy X-ray absorptiometry were compared before and after 12 months of TSEC treatment.ResultsMean age and years since menopause were 55.1 and 4.5 years, respectively. Total hip bone mineral density significantly increased by 0.74% after treatment (P=0.011). The changes in HSA were mainly demonstrated in the narrow femoral neck: cross-sectional area (P=0.003) and cortical thickness (P&lt;0.001) increased significantly. For the shaft region, only SM decreased significantly after treatment (P=0.009). However, most parameters did not change significantly with TSEC treatment in the intertrochanteric and shaft regions.ConclusionsOur findings demonstrate that 12 months of TSEC treatment could improve bone geometry as measured by HSA. The findings suggest that TSEC might be an interesting option for the prevention of fracture as well as osteoporosis in postmenopausal women.
Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity
Authors: Feng Y. , Cirera S. , Taşöz E. , Liu Y. , Olsen L. H. , Christoffersen B. Ø. , Pedersen H. D. , Ludvigsen T. P. , Kirk R. K. , Schumacher-Petersen C. , Deng Y. , Fredholm M. , Gao F. 
Published: March 2021

Objective: Environmental factors can influence obesity by epigenetic mechanisms. The aim of this study was to investigate obesity-related epigenetic changes and the potential for reversal of these changes in the liver of Göttingen minipigs subjected to diet interventions.Methods: High-throughput liquid hybridization capture-based bisulfite sequencing (LHC-BS) was used to quantify the methylation status of gene promotor regions in liver tissue in three groups of male castrated Göttingen minipigs: a standard chow group (SD, N = 7); a group fed high fat/fructose/cholesterol diet (FFC, N = 10) and a group fed high fat/fructose/cholesterol diet during 7 months and reversed to standard diet for 6 months (FFC/SD, N = 12). Expression profiling by qPCR of selected metabolically relevant genes was performed in liver tissue from all pigs.Results: The pigs in the FFC diet group became morbidly obese. The FFC/SD diet did not result in a complete reversal of the body weight to the same weight as in the SD group, but it resulted in reversal of all lipid related metabolic parameters. Here we identified widespread differences in the patterning of cytosine methylation of promoters between the different feeding groups. By combining detection of differentially methylated genes with a rank-based hypergeometric overlap algorithm, we identified 160 genes showing differential methylation in corresponding promoter regions in the FFC diet group when comparing with both the SD and FFC/SD groups. As expected, this differential methylation under FFC diet intervention induced de-regulation of several metabolically-related genes involved in lipid/cholesterol metabolism, inflammatory response and fibrosis generation. Moreover, five genes, of which one is a fibrosis-related gene (MMP9), were still perturbed after diet reversion.Conclusion: Our findings highlight the potential of exploring diet-epigenome interactions for treatment of obesity.
Parameters of Capsulorrhexis and Intraocular Lens Decentration After Femtosecond and Manual Capsulotomies in High Myopic Patients With Cataracts
Authors: Zhu Yanan , Shi Kexin , Yao Ke , Wang Yuyan , Zheng Sifan , Xu Wen , Chen Peiqing , Yu Yibo , Shentu Xingchao 
Published: March 2021

Purpose: To compare the parameters of capsulorrhexis and intraocular lens decentration after femtosecond laser capsulotomy and manual continuous curvilinear capsulorrhexis in high myopic patients with cataracts.Methods: This is a prospective consecutive non-randomized comparative cohort study. Selected patients with axial length &gt; 26.0 mm were divided into femtosecond laser capsulotomy (FS) group and manual continuous curvilinear capsulorrhexis (CCC) group. Five experienced phacoemulsification surgeons conducted all surgeries. Intraoperative complications and post-operative anterior segment photography were recorded. Intraocular lens decentration, area of capsulorrhexis, circularity, and capsule overlap were measured at 1 week, 1 month, and 2 years after surgery. Between group differences of parameters were determined with independent-sample t-test or the Mann–Whitney U-test, analysis of variance test, Pearson chi-square test, and Spearman rank correlation test.Results: The study included 142 eyes (108 patients), 68 eyes in the FS group, and 74 eyes in the CCC group. At 1 week, 1 month, and 2 years after surgery, the area of capsulorrhexis in the CCC group was significantly larger than in the FS group (P &lt; 0.05), while no significant difference was noted in circularity values. The complete overlap ratio in the FS group was significantly higher than that in the CCC group (P &lt; 0.05) at each measured timepoint. Significant correlations were noted between the anterior chamber depth and the area of capsulorrhexis in the CCC group (R = 0.25, P = 0.04), but did not correlate in the FS group (P &gt; 0.05). In patients with an anterior chamber depth &gt;3 mm, the capsule-intraocular lens (IOL) overlap of the CCC group was less than that of the FS group at all measured timepoints after surgery (P &lt; 0.05). Meanwhile, the IOL decentration in the CCC group was significantly greater than that of the FS group in those patients at 2 years after surgery (P &lt; 0.05).Conclusion: In high myopic patients with cataracts, with anterior chamber depth more than 3 mm, femtosecond laser capsulotomy can achieve better capsulorrhexis sizing and centering. Due to more precise capsulotomy and a better capsule-IOL overlap in the FS group, femtosecond laser capsulotomy resulted in better long-term centration of the IOL.
Sex-Specific Association of Endogenous PCSK9 With Memory Function in Elderly Subjects at High Cardiovascular Risk
Authors: Simeone Paola G. , Vadini Francesco , Tripaldi Romina , Liani Rossella , Ciotti Sonia , Di Castelnuovo Augusto , Cipollone Francesco , Santilli Francesca 
Published: March 2021

Background: Growing evidence indicates that cognitive decline and cardiovascular diseases (CVDs) share common vascular risk factors. Protease proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with CV disease risk and has been also involved in neuronal differentiation.Aim: Evaluate whether in patients at high CV risk cognitive function is related to PCSK9 levels.Methods. One hundred sixty-six patients (67 female) were enrolled. A detailed neuropsychological (NP) assessment was performed. PCSK9 levels were measured with ELISA.Results: Men had significantly higher short-term memory, executive function, and praxic and mental representation skills, as reflected by Forward Digit Span (FDS) (p = 0.005), Trail Making Test-A (TMT-A) (p = 0.047), Clock Drawing Test (CDT) (0.016). Endogenous PCSK9 levels were higher in female (p = 0.005). On linear regression analysis PCSK9 predicts short term memory only in females (Beta = 0.408, p = 0.001), with an interaction between PCSK9 and gender (p = 0.004 for interaction PCSK9 by sex). The association of PCSK9 with FDS in female was partially mediated by waist circumference (mediation effect 8.5%).Conclusions: In patients at high CV risk short term memory was directly related to PCSK9 levels only in women, revealing the relevance of sex in this relationship. The association of PCSK9 with memory function may be mediated, at least in part, by waist circumference.
Endolymphatic Hydrops in Patients With Vestibular Migraine and Concurrent Meniere's Disease
Authors: Oh Sun-Young , Dieterich Marianne , Lee Bit Na , Boegle Rainer , Kang Jin-Ju , Lee Na-Ri , Gerb Johannes , Hwang Seung-Bae , Kirsch Valerie 
Published: March 2021

Objective: Intravenous contrast agent enhanced, high-resolution magnetic resonance imaging of the inner ear (iMRI) confirmed that patients with Menière's disease (MD) and vestibular migraine (VM) could present with endolymphatic hydrops (EH). The present study aimed to investigate EH characteristics and their interrelation to neurotologic testing in patients with VM, MD, or VM with concurrent MD (VM-MD).Methods: Sixty–two patients (45 females, aged 23–81 years) with definite or probable VM (n = 25, 19 definite), MD (n = 29, 17 definite), or showing characteristics of both diseases (n = 8) were included in this study. Diagnostic workup included neurotologic assessments including video-oculography (VOG) during caloric stimulation and head-impulse test (HIT), ocular and cervical vestibular evoked myogenic potentials (o/cVEMP), pure tone audiometry (PTA), as well as iMRI. EH's degree was assessed visually and via volumetric quantification using a probabilistic atlas-based segmentation of the bony labyrinth and volumetric local thresholding (VOLT).Results: Although a relevant number of VM patients reported varying auditory symptoms (13 of 25, 52.0%), EH in VM was only observed twice. In contrast, EH in VM-MD was prevalent (2/8, 25%) and in MD frequent [23/29, 79.3%; χ2(2) = 29.1, p &lt; 0.001, φ = 0.7]. Location and laterality of EH and neurophysiological testing classifications were highly associated (Fisher exact test, p &lt; 0.005). In MD, visual semi-quantitative grading and volumetric quantification correlated highly to each other (rS = 0.8, p &lt; 0.005, two-sided) and to side differences in VOG during caloric irrigation (vestibular EH ipsilateral: rS = 0.6, p &lt; 0.05, two-sided). In VM, correlations were less pronounced. VM-MD assumed an intermediate position between VM and MD.Conclusion: Cochlear and vestibular hydrops can occur in MD and VM patients with auditory symptoms; this suggests inner ear damage irrespective of the diagnosis of MD or VM. The EH grades often correlated with auditory symptoms such as hearing impairment and tinnitus. Further research is required to uncover whether migraine is one causative factor of EH or whether EH in VM patients with auditory symptoms suggests an additional pathology due to MD.