bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fruit juice mediated multicomponent reaction for the synthesis of substituted isoxazoles and their in vitro bio evaluation
Authors: Gulati Susheel , Singh Rajvir , Sangwan Suman 
Published: March 2021

Abstract
Abstract
A simple, efficient and eco-friendly procedure for the synthesis of isoxazoles derivatives (4a-4h) using one-pot three components reaction between substituted aldehydes (1a), methyl acetoacetate (2a) and hydroxylamine hydrochloride (3a) has been achieved in presence of Cocos nucifera L. juice, Solanum lycopersicum L. juice and Citrus limetta juice respectively. This protocol is natural acid catalysed multicomponent reaction for the synthesis of potentially bioactive isoxazole derivatives. The homogeneity of synthesized compounds was confirmed by melting point and thin layer chromatography. The synthesized compounds were characterized by using 1HNMR, FTIR and CHN spectral analysis and evaluated for in vitro herbicidal activity against Raphanus sativus L. (Radish seeds). The compounds (4a-4h) were also screened for their fungicidal activity against Rhizoctonia solani and Colletotrichum gloeosporioides by poisoned food techniques. Antibacterial activity was also tested against Erwinia carotovora and Xanthomonas citri by inhibition zone method. From bio evaluation data, it was found that compound 4b was most active against Raphanus sativus L. (root) and Raphanus sativus L. (shoot) respectively. Compound 4b was also found most active against both the fungus viz. R. solani and C. gloeosporioides showing maximum percentage growth inhibition i.e. 90.00 against R. solani and 82.45 against C. gloeosporioides at 2000 µg/mL concentration. Compound 4h has shown maximum inhibition zone i.e. 3.00-9.60 mm against Erwinia carotovora at 2000 µg/mL concentration. Maximum Xanthomonas citri growth was also inhibited by compound 4h showing inhibition zone 1.00–5.00 mm at highest concentration. Less reaction time, high yields of desired products, mild reaction conditions, simple work-up, cost effectiveness and no need of column chromatography are some beauties of present methodology.
Evaluating the impact of decontamination interventions performed in sequence for mass casualty chemical incidents
Authors: Collins Samuel , Williams Natalie , Southworth Felicity , James Thomas , Davidson Louise , Orchard Emily , Marczylo Tim , Amlôt Richard 
Published: March 2021

Abstract
The Initial Operational Response (IOR) to chemical incidents is a suite of rapid strategies including evacuation, disrobe and improvised and interim decontamination. IOR and Specialist Operational Response (SOR) decontamination protocols involving mass decontamination units would be conducted in sequence by UK emergency services following a chemical incident, to allow for safe onward transfer of casualties. As part of a series of human volunteer studies, we examined the effectiveness of IOR and SOR decontamination procedures alone and in sequence. Specifically, we evaluated the additional contribution of SOR, when following improvised and interim decontamination. Two simulants, methyl salicylate (MeS) with vegetable oil and benzyl salicylate (BeS), were applied to participants’ skin. Participants underwent improvised dry, improvised wet, interim wet, specialist decontamination and a no decontamination control. Skin analysis and UV photography indicated significantly lower levels of both simulants remaining following decontamination compared to controls. There were no significant differences in MeS levels recovered between decontamination conditions. Analysis of BeS, a more persistent simulant than MeS, showed that recovery from skin was significantly reduced following combined IOR with SOR than IOR alone. These results show modest additional benefits of decontamination interventions conducted in sequence, particularly for persistent chemicals, supporting current UK operational procedures.
Health Literacy and Health Outcomes in Patients with Low Back Pain – A Scoping Review
Authors: See Clarence Ye King , Smith Helen Elizabeth , Car Lorainne Tudor , Protheroe Joanne , Wong Wei Cong , Bartlam Bernadette 
Published: March 2021

Abstract
BACKGROUND: The World Health Organisation highlights low back pain as a leading and growing cause of disability worldwide. In the field of chronic pain, higher health literacy is linked to lower pain intensity and better pain control. However, there remains a paucity of evidence, with a recent systematic review finding only three studies meeting its inclusion criteria. OBJECTIVES: This scoping review had two objectives in exploring research in chronic back pain, which were to identify:1) The health literacy measures currently employed for back pain and the aspects of health literacy they include.2) The back-pain health outcomes included in such work and the extent to which these reflect the core outcome set for clinical trials in non-specific low back pain.METHODS: The search broadened the search strategy used in the systematic review, with the eligibility criteria defined by the Joanna Briggs Institute PCC mnemonic, namely: · Population – Patients with LBP (≥ 10% of study population), of any age, gender, or race· Concept – Relationship of LBP health outcomes to HL· Context – Any healthcare setting, in any geographical settingIt was conducted using thirteen bibliographic databases, employing medical subject heading (MeSH) terms for low back pain and health literacy, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A thematic framework approach was used for analysis.RESULTS: The search yielded ten relevant studies for inclusion, amongst which a total of nine health literacy measures and 50 health outcome measures were used. The health outcomes assessed by the included studies could be broadly categorised into: Pain, Disability, Behaviour, Knowledge and Beliefs, and Resource Utilisation. Most outcome measures employed (36 out of 50) were not directly relevant to addressing the core outcome set for clinical trials in non-specific low back pain.CONCLUSIONS: A dearth of studies in this field of research was noted, especially in Asia and low-middle income countries. Methodological limitations were identified, including in study design and outcome measures. To allow for comparison across findings and the development of a rigorous evidence base, future work should include the core outcome set for clinical trials in non-specific low back pain. Furthermore, research thus far has focused on a narrow range of populations and there is an urgent need to broaden the evidence-base to include those with characteristics known to be moderators in health outcomes. Such work demands the incorporation of comprehensive measures of health literacy that have both generic and culturally sensitive components.
Development a set of scales to assess job satisfaction among physicians in Peru: validity and reliability assessment
Authors: Villarreal-Zegarra David , Torres-Puente Roberto , Castillo-Blanco Ronald , Cabieses Baltica , Bellido-Boza Luciana , Mezones-Holguín Edward 
Published: March 2021

Abstract
Background: To assess the evidences of validity and reliability of a set of scales on different areas of job satisfaction (general professional activity, health services management, and working conditions) in Peruvian physicians based on data from the National Survey of Satisfaction of Users in Health (ENSUSALUD). Method: We carried out a psychometric study based on secondary data analysis. Participants were selected from a two-stage probabilistic national representative sampling stratified by political region. Validity was assessed by exploratory and confirmatory factor analysis and measurement invariance analysis. Reliability was assessed by internal consistency coefficients (alpha and omega). The set of scales was composed of items related to three different areas of job satisfaction: 1) satisfaction with general professional activity, 2) satisfaction with the health services management, and 3) satisfaction with the working conditions of the health center. Results: We included 2,137 participants in the analysis. General professional activity scale with 6 items (CFI=0.946; RMSEA=0.071; SRMR=0.035) and the health services management scale with 8 items (CFI=0.972; RMSEA=0.081; SRMR=0.028) showed good measurement properties for the one-dimensional model. The scale of working conditions presented adequate measurement properties with a two-dimensional model (CFI=0.914; RMSEA=0.080; SRMR=0.055): individual conditions (8 items) and infrastructural conditions (3 items). The invariance analysis presented that comparisons can be made between sex, age, civil status, medical specialty, working in other institutions, work-related illness, chronic disease, and time working in health care center. All scales had adequate internal consistency (ω and α between 0.70 and 0.90). Conclusions: The set of scales solid factorial structure and measurement invariance, which makes it possible for group comparison. They also achieved stability in their scores as they showed adequate internal consistency coefficients. Based on our findings, these instruments are suitable for measuring job satisfaction among outpatient physicians throughout Peru, as our data is representative at the country level.
The System of Intergovernmental Relations: are there any Incentives for Economic Development
Authors: Lykova L. N. 
Published: March 2021

In the last decade, the system of inter-budgetary relations has undergone some changes, which were mainly of a partial nature. The result is an established model with a significant and non-decreasing number of subsidized regions, a high level of income concentration, and subfederal budgets that differ significantly in the degree of income base diversification. At the same time, if half of the regions have an insufficient level of economic development to finance the necessary expenditures (relative to GRP), then for the other half this level is quite sufficient within the GRP potential, but the current tax system and the procedure for distributing tax revenues do not allow this, which requires replacing tax revenues with federal transfers. This model does not generate intention in supporting economic growth and economic activity in the regions and deprives them of incentives for development. The way out of this situation may be to take into account the formed macro-trends (changes in the place of the hydrocarbon economy, the place in the value chains, etc.) in the formation of an explicitly asymmetric model of intergovernmental relations, which may allow us to use the intention in economic development at the level of the subjects of the Russian Federation.
Development and Implementation of a Multidisciplinary Electronic Discharge Readiness Tool: User-Centered Design Approach
Authors: Keniston Angela , McBeth Lauren , Pell Sr Jonathan , Bowden Kasey , Ball Stephen , Stoebner Kristin , Scherzberg Elaina , Moore Susan L , Nordhagen Jamie , Anthony Amanda , Burden Marisha 
Published: March 2021

Background
Typical solutions for improving discharge planning often rely on one-way communication mechanisms, static data entry into the electronic health record (EHR), or in-person meetings. Lack of timely and effective communication can adversely affect patients and their care teams.

Objective
Applying robust user-centered design strategies, we aimed to design an innovative EHR-based discharge readiness communication tool (the Discharge Today tool) to enable care teams to communicate any barriers to discharge, the status of patient discharge readiness, and patient discharge needs in real time across hospital settings.

Methods
We employed multiple user-centered design strategies, including exploration of the current state for documenting discharge readiness and directing discharge planning, iterative low-fidelity prototypes, multidisciplinary stakeholder meetings, a brainwriting premortem exercise, and preproduction user testing. We iteratively collected feedback from users via meetings and surveys.

Results
We conducted 28 meetings with 20 different stakeholder groups. From these stakeholder meetings, we developed 14 low-fidelity prototypes prior to deploying the Discharge Today tool for our pilot study. During the pilot study, stakeholders requested 46 modifications, of which 25 (54%) were successfully executed. We found that most providers who responded to the survey reported that the tool either saved time or did not change the amount of time required to complete their discharge workflow (21/24, 88%). Responses to open-ended questions offered both positive feedback and opportunities for improvement in the domains of efficiency, integration into workflow, avoidance of redundancies, expedited communication, and patient-centeredness.

Conclusions
Survey data suggest that this electronic discharge readiness tool has been successfully adopted by providers and clinical staff. Frequent stakeholder engagement and iterative user-centered design were critical to the successful implementation of this tool.
Patient-Facing Mobile Apps to Support Physiotherapy Care: Protocol for a Systematic Review of Apps Within App Stores (Preprint)
Authors: Merolli Mark , Francis Jill J , Vallance Patrick , Bennell Kim L , Malliaras Peter , Hinman Rana S 
Published: March 2021

BACKGROUND

Care delivered by physiotherapists aims to facilitate engagement in positive health behaviors by patients (eg, adherence to exercise). However, research suggests that behavioral interventions are frequently omitted from care. Hence, better understanding of strategies that can be used by physiotherapists to support patients to engage in positive behaviors is important and likely to optimize outcomes. Digital health interventions delivered via mobile apps are garnering attention for their ability to support behavior change. They have potential to incorporate numerous behavior change techniques (BCTs) to support goals of physiotherapy care, including but not limited to self-monitoring, goal setting, and prompts/alerts. Despite their potential to support physiotherapy care, much is still unknown about what apps are available to consumers, the BCTs they use, their quality, and their potential to change behaviors.

OBJECTIVE

The primary aim of this study is to systematically review the mobile apps available in app stores that are intended for use by patients to support physiotherapy care, including the BCTs within these apps. The secondary aims are to evaluate the quality and behavior change potential of these apps.

METHODS

A systematic review of mobile apps in app stores will be undertaken. This will be guided by recommendations for systematic reviews in line with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement but adapted to suit our app store search, consistent with similar systematic reviews of apps published in the <i>Journal of Medical Internet Research</i>. Apple Store and Google Play will be searched with a two-step search strategy, using terms relevant to physiotherapy, physiotherapists, and common physiotherapy care. Key eligibility criteria will include apps that are intended for use by patients and are self-contained or stand-alone without the need of additional wearable devices or other add-ons. Included apps will be coded for BCTs and rated for quality using the Mobile Application Rating Scale (MARS) and for potential to change behavior using the App Behavior Change Scale (ABACUS).

RESULTS

App store search and screening are expected to be completed in 2021. Data extraction and quality appraisal are expected to commence by November 2021. The study results are expected to be published in a subsequent paper in 2022.

CONCLUSIONS

Knowledge gained from this review will support clinical practice and inform research by providing a greater understanding of the quality of currently available mobile apps and their potential to support patient behavior change goals of physiotherapy care.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/29047
Pengaruh Kepadatan Penduduk Terhadap Jumlah Kasus Mingguan Covid-19 Di Kabupaten Badung Provinsi Bali
Authors: Dwi Novia Wahyuni  
Published: March 2021

Geografi mengkaji fenomena di Bumi dengan menganalisis ragam dinamika termasuk pada unsur sosial lingkungan, seperti terjadinya sebaran pandemi Covid-19 di Kabupaten Badung Provinsi Bali dengan pendekatan spasial. Adapun tujuan dalam penelitian ini ialah mengetahui hubungan antara variabel kepadatan penduduk di Kabupaten Badung dengan kasus COVID-19 dan memetakan tingkat kejadian mingguan COVID-19. Dalam melihat analisis pengaruh antar variabel digunakan metode analisis korelasi dan regresi, sedangkan dalam memetakan serta menganalisis tingkat kejadian menggunakan software ArcGIS. Hasil dari penelitian ini adalah terdapat hubungan sangat lemah antar variabel sebesar 1,7%, dikarenakan kejadian COVID-19 di Kabupaten Badung hanya meningkat pada kecamatan yang memiliki kepadatan penduduk sedang sehingga variabel kepadatan penduduk bukanlah penyebab utama dan tidak berpengaruh secara signifikan terhadap penyebaran COVID-19. Selain itu, temuan dari hasil interpretasi peta menunjukkan terdapat beberapa kecamatan yang tetap konstan pada tingkat kejadian rendah yang disebabkan oleh kepatuhan masyarakat dalam menerapkan kebijakan pemerintah setempat.
Perancangan Aplikasi Rental Mobil Pada Sumardi Rental
Authors: Salamah Umniy , Rusandy Gusty Age 
Published: March 2021

Perkembangan teknologi informasi telah bergerak dengan cepat. Hal ini menimbulkan perubahan, dimana pelanggan tidak lagi puas berinteraksi hanya secara fisik, namun pelanggan menginginkan suatu nilai lebih yang bisa diperoleh dari perusahaan, maka Aplikasi Rental Mobil Berbasis Web Menggunakan Framework Codeigniter perlu untuk dibuat. Sehingga customer tidak perlu repot-repot datang ke tempat rental mobil hanya untuk melihat jenis-jenis mobil yang disewakan. Sisten informasi rental mobil online dapat dilaksanakan di komputer rumah, kantor, warnet, dan dimanapun asalkan ada media yang terhubung dengan internet.
Optical Character Recognition Citra Kata Kanji Menggunakan Ekstraksi Fitur Algoritma Chain Code dan Algoritma L1-Metric
Authors: Hartono Kevin Laurence , Surya Karman , Agung Halim 
Published: March 2021

Kanji merupakan salah satu bahasa yang berasal dari negara Jepang. Bahasa Jepang sendiri telah menyebar di berbagai negara terutama di Indonesia. Namum dikarenakan bahasa Jepang bukanlah bahasa yang mudah dipelajari karena bahasa Jepang tidak termasuk kedalam bahasa Internasional. Oleh karena itu diperlukan sistem yang bisa membaca bahasa aksara bahasa Jepang khususnya kanji. Penelitian ini akan difokuskan pada perancangan aplikasi pengenalan karakter optik dari aksara kanji menggunakan ekstraksi fitur chain code untuk melakukan pengenalan pola dari citra aksara kanji dan perhitungan jarak manhattan distance (L1 Metric). Dalam membangun aplikasi digunakan bahasa pemrograman pascal menggunakan Lazarus IDE dan integrasi sistem basis data. Proses dalam penelitian ini terdiri dari 5 tahap yaitu pre-processing, segmentasi, filtering spasial linier, ekstraksi fitur chain code, dan perhitungan jarak nilai fitur. Jarak citra kanji yang diuji akan dibandingkan dengan citra kanji yang sudah dilatih di basis data untuk mencari jarak terkecil. Hasil pengujian yang dilakukan dengan algoritma chain code dan manhattan distance (L1 Metric) menunjukkan bahwa sebesar 21.82% citra tulisan tangan kanji berhasil dikenali dan 78.18% mengalami kegagalan dalam mengenali citra yang diuji
Rancang Bangun Sistem Deteksi Pelanggaran Lalu Lintas dalam Simulator Mengemudi menggunakan Unity Game Engine
Authors: Iqbal Mohammad , Karmilasari Karmilasari , Karyanti Yuli , Chalri Yulia 
Published: March 2021

Faktor penyebab kecelakaan lalu lintas secara umum, terdiri dari beberapa hal, yaitu kondisi sarana transportasi, faktor kelalaian manusia, dan alam, serta belum optimalnya penegakan hukum lalu lintas. Namun demikian, hal yang menjadi penyebab utama tingginya angka kecelakaan lalu lintas adalah kelalaian manusia, sehingga diperlukan kesadaran berlalu lintas yang baik bagi masyarakat terutama untuk pengendara kendaraan bermotor kalangan usia produktif. Fakta bahwa pengemudi kendaraan yang memiliki sedikit pengalaman mengemudi lebih berisiko mengalami kecelakaan dibandingkan pengemudi yang telah berpengalaman. Pengalaman tersebut sangat mempengaruhi keterampilan kontrol, keterampilan pemrosesan, kalibrasi diri, persepsi risiko, dan motivasi atau sikap yang berhubungan dengan keselamatan. Dalam kegiatan ini, Sistem Simulator mengemudi menjadi sistem penting yang dapat digunakan meningkatkan keahlian. Tuntutan membuat situasi yang mirip dengan keadaan sesungguhnya di jalan raya menjadi tantangan bagi para pengembang untuk membuat desain simulator yang baik. Dalam penelitian ini dihasilkan rancang bangun sistem deteksi pelanggaran lalu lintas dalam simulator mengemudi dengan menggunakan alat bantu Unity Game Engine, yang telah diuji secara sistem black box.
Cold Coagulation of high grade premalignant disease of the cervix – standing the test of time: a Retrospective study
Authors: RAGUPATHY KALPANA , Jayasinghe Thummini , McMullen Wendy 
Published: March 2021

Analyse long term (20 years) cytology and histology outcomes following
treatment of high grade cervical intraepithelial neoplasia (HGCIN) with
Cold Coagulation (CC). Methods All women having CC for HGCIN
between Jan 1996 and December 1998 (36 months; n=885) were identified;
data was collected on age of patients, symptoms, colposcopy findings and
biopsy reports. Local and national (cytology and colposcopy) databases
and colposcopy records were used to collect long term follow up data.
Probability of CIN recurrence was assessed using Kaplan Meir ‘Survival’
curve. Results Follow up data (available for 796) was collected in
2018 capturing 20 years of follow-up data. 281 women were treated for
CIN2 and 515 women for CIN3. 791/796(>99%) were treated at
first visit and 152/796(19%) had symptoms at presentation.
262/796(33%) had evidence of glandular involvement on pre-treatment
biopsy. Probability of having consistently normal cytological follow up
was 92%, 89%, 86% and 83% at 5, 10, 15 and 20 years
respectively. Cumulative probability of having recurrent HGCIN was
0.5% at 5 years, 1% at 10years, 1.9% at 15 years and 3% at 18
years. Conclusion CC is a safe and effective treatment for HGCIN
which is now shown to have stood the test of time. We advise more
widespread adoption in the UK and globally so long as agreed criteria
are met.
DISJUNCTIVISM ABOUT INTENDING
Authors: Levy Yair 
Published: March 2021

AbstractThe overwhelmingly predominant view in philosophy sees intending as a mental state, specifically a plan-like state. This paper rejects the predominant view in favor of a starkly opposed novel alternative. After criticizing both the predominant Bratman-esque view of intention, and an alternative view inspired by Michael Thompson, the paper proceeds to set out and defend the idea that acting with an intention to V should be understood disjunctively, as (roughly) either one’s V-ing intentionally or one’s performing some kind of failed intentional V-ing, where the two disjuncts share no common state of intention. Instructive structural parallels to perceptual disjunctivism are pointed out, and the view is shown, unlike its rivals, to successfully extend to capture both prospective and present intention, thereby unifying the three different guises of intention.