bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep disorders and their relationship to other psychiatric disorders in women with breast cancer: a case-control study
Authors: Gabra Romany H. , Hashem Doaa F. 
Published: February 2021

Abstract
Background
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year. The aim of the study is to determine prevalence of sleep disorders among patients with breast cancer, its correlation with different psychological symptoms and the ability of such symptoms to predict sleep disorders among those patients. The current study is a case-control study compromised of 153 participants, 93 breast cancer patients versus 60 cross-matched healthy control persons recruited from the outpatient clinic of Oncology Department—Assiut University Hospital. Arabic versions of Beck’s Depression Inventory, symptom checklist, and Sleep Disorder Scale were used to evaluate depression, obsession, sensitivity, anxiety, hostility, phobic anxiety, paranoia ideation, psychoticism, and sleep disorders, respectively. The correlation of this data with clinical and social variables of these patients and the effect of such variables on each other were also determined.

Results
A statistically higher prevalence of sleep disorders and depression was reported among breast cancer patients compared to the control group. Also, patients with breast cancer scored statistically higher mean scores in somatization, obsession, sensitivity, anxiety, and phobic anxiety than those of the control group.

Conclusions
Prevalence of sleep disorders, depression, obsession, sensitivity, anxiety, hostility, phobic anxiety, paranoia ideation, and psychoticism among breast cancer patients poses a challenge to the treatment of such patients. Misdiagnosis and mismanagement lead to poor treatment outcomes of both cancer disease and psychiatric disorders.
COVID-19 infection and cardiac angiosarcoma: a dangerous combination—a case report
Authors: Endara Santiago A. , Dávalos Gerardo A. , Molina Gabriel A. , Zavala Aldo B. , Ponton Patricia M. , Brito Maribel , Nieto Carlos , Ullauri Vladimir E. 
Published: February 2021

Abstract
Background
The COVID-19 pandemic has strained all medical systems, especially in countries like Ecuador, where health services were already limited. These conditions, combined with a deadly and unusual disease, like primary heart angiosarcoma, can lead to severe outcomes. Angiosarcomas represent the most common and aggressive primary malignant heart tumor; regretfully, its clinical manifestations are vague and can be easily missed. Most patients become symptomatic when there is local invasion, embolization, or metastases, leading to late diagnosis and poor survival. High clinical awareness, adequate diagnosis, and prompt treatment are vital in these rare diseases, in which time is of paramount importance.

Case presentation
We report the case of a 28-year-old female who had cough, hemoptysis, and ground-glass opacities in the CT (computed tomography). Since Ecuador is in the middle of this pandemic, she was misdiagnosed and mistreated. Primary heart angiosarcoma was diagnosed, and regretfully, the patient suffered multiple complications due to diagnosis and died.

Conclusion
To this day, most cardiac angiosarcomas are found in a late-stage with distal metastasis and advanced local invasion. Sadly, this tumor is frequently missed due to its incidence and broad-spectrum of clinical symptoms. Considering that its manifestations can be misleading, misdiagnosis can occur, especially in pandemic times. Therefore, knowledge of other pathologies prevents COVID-19 from overshadowing other diagnoses, hence preventing delayed diagnosis or even misdiagnosis and consequent adverse outcomes for patients.
Short-term outcomes of reconstruction of extensively diseased left anterior descending artery with or without endarterectomy: a propensity score analysis
Authors: Fayad El-Sayed A. , Amr Mohamed A. 
Published: February 2021

Abstract
Background
Surgical management of extensively diseased left anterior descending artery (LAD) is challenging. Reconstruction of the LAD with endarterectomy may lead to intimal disruption and affect the outcomes of surgery. We aimed to compare hospital outcomes of surgical reconstruction of extensively diseased LAD with and without endarterectomy.

Results
This retrospective multicenter study included 275 patients who had reconstruction of extensively diseased LAD from 2015 to 2019. We divided patients into two groups: group 1 (n = 138) included patients who had plaque exclusion and patching, and group 2 (n = 137) included patients who had endarterectomy and patching. All patients had primary isolated on-pump coronary artery bypass grafting with the left internal mammary artery (LIMA) grafting to LAD. On-lay LIMA patch was used in 118 patients in group 1 and 132 patients in group 2. A saphenous vein patch was used in 20 patients in group 1 and 5 patients in group 2. Propensity score matching identified 100 matched pairs. The age in group 1 was 56.1 ± 7.8 years versus 55.2 ± 7.1 in group 2 (P = 0.34). There were 119 (86.2%) males in group 1 and 113 (82.5%) in group 2 (P = 0.39). After matching, there was no difference in preoperative and operative data. In the matched groups, low cardiac output occurred in 6 (6%) patients in group 1 and 4 (4%) patients in group 2 (P = 0.73). There was no difference in mechanical ventilation time between groups (9 (25th- 75th percentiles: 7.5–14) hours in group 1 vs. 9 (7–14) hours in groups 2; P = 0.93). Length of hospital stay was 7 (6–9) days in group 1 and 7 (6–10) days in group 2 (P = 0.57). Mortality occurred in one patient in group 1. We did not report early graft occlusion cases in group 1, and one patient had a myocardial infarction in group 2.

Conclusion
The outcomes after reconstructing extensively diseased LAD with endarterectomy or plaque exclusion and patching are satisfactory and comparable in both approaches.
Demographic and clinical phenotypic differences between people with dissociative seizures and those with other psychiatric disorders
Authors: Smakowski Abigail , Bird Jacob S. , Pritchard Megan , Mula Marco 
Published: February 2021

Background
A large amount of literature surrounds the differences between dissociative neurological symptom disorder with non-epileptic seizures (DNSD-S) and epilepsy.

Aims
To explore the research gap on phenotypic differences between DNSD-S and other psychiatric disorders.

Method
We conducted a case–control study of 1860 patients (620 patients with DNSD-S and 1240 controls with other psychiatric disorders) seen at the South London and Maudsley Hospital NHS Trust between 2007 and 2019.

Results
Compared with the controls, the patients with DNSD-S were more likely to be female (76 v. 47%, P < 0.001), of White ethnicity (77 v. 60%, P < 0.001), married (34 v. 14%, P < 0.001) and living in areas of lower socioeconomic status (−3.79, 95% CI −2.62 to −4.96, P < 0.001). Two peaks for age at diagnosis were observed for DNSD-S: the early 20s and late 40s. After 31 years of age, men's chance of being diagnosed with DNSD-S increased from 19 to 28% (P = 0.009). People with DNSD-S presented more commonly with a history of a neurological episodic or paroxysmal disorder (OR = 12, 95% CI 7.82–20.26), another dissociative disorder (OR = 10, 95% CI 1.64– 65.95) or unclassified signs or symptoms (OR = 4, 95% CI 2.61–6.43). Neither anxiety, depression nor other somatoform disorders predicted subsequent diagnosis of DNSD-S, and controls had a larger proportion of preceding psychiatric diagnoses than patients with DNSD-S (65 v. 49%, P < 0.001).

Conclusions
This is the first study comparing demographic and phenotypic correlates of patients with DNSD-S against a large cohort of psychiatric patients. These data will inform development and drive service needs in psychiatry for people with DNSD-S.
How the Critique of Heaven Confines the Critique of the Earth
Authors: Amer Meziane Mohamad 
Published: February 2021

AbstractThis essay examines the effects of the critique of religion on the critique of capital and how the former confines the latter. It asks: What remains of the concepts of alienation or fetishism if they all stem from an anthropology of religion that seems to be criticized? If religion ceases to refer to an anthropological essence and is criticized as a European colonial concept, then what happens to the critique of capital? It argues that what Marx considers the condition for critique seems to be the blind spot of Western Marxism. Without a critical analysis of how the concept of religion is constructed and how religion is thus described as a human invention, Marxism cannot know itself. If Marx is a “critic of the critique of religion,” this gesture must apply to Marx as well as to Marxism itself. The critique of capitalism might need an alternative foundation if the anthropological concept of religion that supported it collapses. It is therefore impossible to maintain the critique of capital as it is while refusing the critique of religion that lies at its foundation.
Workers Entering the Prison
Authors: McGowan Christopher 
Published: February 2021

AbstractThis article argues that Steve McQueen’s Hunger (2008) represents an unexpected but compelling mutation of the genre of postindustrial labor film. Hunger depicts the protests of Irish republican prisoners inside the Maze Prison that culminated in the 1981 Irish hunger strike. At the same time, the film develops an extended representation of the labor of the prison workers who beat, humiliate, care for, and counsel the prisoners throughout the protests. By combining and reworking the genres of labor film, prison film, and Irish Troubles film, Hunger imagines the prison as a microcosm of a deindustrialized Northern Irish economy where labor has left the factory and become conjoined to the disciplinary power of the state, either as police work or as care work. In this way, Hunger attends to the “spirit” of what Lenin called the “labor aristocracy,” here reduced to the work of maintaining the very boundary between itself and those excluded from it. McQueen’s attention to the body and to the affective dimensions of labor and struggle, the article argues, allows Hunger to achieve a uniquely committed, totalizing representation of the political economy of Northern Ireland.
Dealing with predictable and unpredictable temperatures in a climate change context: the case of parasitoids and their hosts
Authors: Le Lann Cécile , van Baaren Joan , Visser Bertanne 
Published: February 2021

ABSTRACT
The Earth's climate is changing at a rapid pace. To survive in increasingly fluctuating and unpredictable environments, species can either migrate or evolve through rapid local adaptation, plasticity and/or bet-hedging. For small ectotherm insects, like parasitoids and their hosts, phenotypic plasticity and bet-hedging could be critical strategies for population and species persistence in response to immediate, intense and unpredictable temperature changes. Here, we focus on studies evaluating phenotypic responses to variable predictable thermal conditions (for which phenotypic plasticity is favoured) and unpredictable thermal environments (for which bet-hedging is favoured), both within and between host and parasitoid generations. We then address the effects of fluctuating temperatures on host–parasitoid interactions, potential cascading effects on the food web, as well as biological control services. We conclude our review by proposing a road map for designing experiments to assess if plasticity and bet-hedging can be adaptive strategies, and to disentangle how fluctuating temperatures can affect the evolution of these two strategies in parasitoids and their hosts.
Influence of time and hydration (ageing) on flexural strength of Yttrium stabilized Zirconia polycrystals (Y-TZP) fabricated with different CAD-CAM Systems
Authors: Al Aali Khulud A , Alresayes Saad , Alhenaki Aasem M , Vohra Fahim , Abduljabbar Tariq 
Published: February 2021

Objectives: To evaluate the effect of time and hydration (ageing) on flexural strength of yttrium-stabilized zirconia polycrystals (Y-TZP) zirconia fabricated from three different materials.
Methods: This in-vitro study was performed from June to September 2019. Y-TZP bars, measuring 2 x 3 x 20 mm were prepared and sintered from three different materials, Group-1: LAVA™ Zirconia (3M™ ESPE, US) (control) Group-2: Vita In-Ceram YZ (VITA, Germany) and Group-3: Aadva™ Zirconia (Zr) (GC Advanced technologies Inc.). 30 zirconia bars per group were prepared using sectioning of blocks with isomet saw. Followed by sintering in furnaces for recommended temperature cycles. One side of bars were polished and beveled for flexural testing. Groups of specimens were divided into subgroups of 3 (n=10) based on the ageing (distilled water in the incubator at 37ºC) durations (48 Hrs and two and half years). Ten specimens in each material groups were not aged (controls). Samples were exposed to a static force in a three-point bend test using a universal instron-testing machine until fracture. Scanning electron microscopic assessment was performed for fractured specimens for ageing. Data was analyzed using ANOVA and Tukey post hoc test.
Results: The mean flexural strength at baseline for Group-1: LAVA™ Zirconia, group (632.7 ± 136.5 MPa) 2: Vita In-Ceram YZ (1036.3 ± 229.6 MPa), and Group-3: Aadva™ Zirconia (1171.3 ± 266.3 MPa) were significantly different. Group-2 and Group-3 specimens showed higher strength compared to Group-1 specimens, irrespective of the ageing duration (p<0.05). Analysis of pooled data for flexural strength for materials by aging period (baseline, after 48 hours and after 2 and ½ years) showed that there was significant reduction of strength with increasing duration (p<0.05).
Conclusions: Y-TZP showed variations in flexural strength depending on the material type. Ageing duration exhibited significant influence on the flexural strength of Y-TZP when comparing no ageing to two and half years. Vita In-Ceram YZ and Aadva Zirconia (Zr) showed higher and clinically acceptable flexural strength outcomes.
doi: https://doi.org/10.12669/pjms.37.3.3996
How to cite this:Al-Aali KA, Alresayes S, Alhenaki AM, Vohra F, Abduljabbar T. Influence of time and hydration (ageing) on flexural strength of Yttrium stabilized Zirconia polycrystals (Y-TZP) fabricated with different CAD-CAM Systems. Pak J Med Sci. 2021;37(3):833-839. doi: https://doi.org/10.12669/pjms.37.3.3996
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RP-REP Ribosomal Profiling Reports: an open-source cloud-enabled framework for reproducible ribosomal profiling data processing, analysis, and result reporting
Authors: Jensen Travis L. , Hooper William F. , Cherikh Sami R. , Goll Johannes B. 
Published: February 2021

Ribosomal profiling is an emerging experimental technology to measure protein synthesis by sequencing short mRNA fragments undergoing translation in ribosomes. Applied on the genome wide scale, this is a powerful tool to profile global protein synthesis within cell populations of interest. Such information can be utilized for biomarker discovery and detection of treatment-responsive genes. However, analysis of ribosomal profiling data requires careful preprocessing to reduce the impact of artifacts and dedicated statistical methods for visualizing and modeling the high-dimensional discrete read count data. Here we present Ribosomal Profiling Reports (RP-REP), a new open-source cloud-enabled software that allows users to execute start-to-end gene-level ribosomal profiling and RNA-Seq analysis on a pre-configured Amazon Virtual Machine Image (AMI) hosted on AWS or on the user’s own Ubuntu Linux server. The software works with FASTQ files stored locally, on AWS S3, or at the Sequence Read Archive (SRA). RP-REP automatically executes a series of customizable steps including filtering of contaminant RNA, enrichment of true ribosomal footprints, reference alignment and gene translation quantification, gene body coverage, CRAM compression, reference alignment QC, data normalization, multivariate data visualization, identification of differentially translated genes, and generation of heatmaps, co-translated gene clusters, enriched pathways, and other custom visualizations. RP-REP provides functionality to contrast RNA-SEQ and ribosomal profiling results, and calculates translational efficiency per gene. The software outputs a PDF report and publication-ready table and figure files. As a use case, we provide RP-REP results for a dengue virus study that tested cytosol and endoplasmic reticulum cellular fractions of human Huh7 cells pre-infection and at 6 h, 12 h, 24 h, and 40 h post-infection. Case study results, Ubuntu installation scripts, and the most recent RP-REP source code are accessible at GitHub. The cloud-ready AMI is available at AWS (AMI ID: RPREP RSEQREP (Ribosome Profiling and RNA-Seq Reports) v2.1 (ami-00b92f52d763145d3)).
Interactive biomedical segmentation tool powered by deep learning and ImJoy
Authors: Ouyang Wei , Le Trang , Xu Hao , Lundberg Emma 
Published: February 2021

Deep learning-based methods play an increasingly important role in bioimage analysis. User-friendly tools are crucial for increasing the adoption of deep learning models and efforts have been made to support them in existing image analysis platforms. Due to hardware and software complexities, many of them have been struggling to support re-training and fine-tuning of models which is essential to avoid overfitting and hallucination issues when working with limited training data. Meanwhile, interactive machine learning provides an efficient way to train models on limited training data. It works by gradually adding new annotations by correcting the model predictions while the model is training in the background. In this work, we developed an ImJoy plugin for interactive training and an annotation tool for image segmentation. With a small example dataset obtained from the Human Protein Atlas, we demonstrate that CellPose-based segmentation models can be trained interactively from scratch within 10-40 minutes, which is at least 6x faster than the conventional annotation workflow and less labor intensive. We envision that the developed tool can make deep learning segmentation methods incrementally adoptable for new users and be used in a wide range of applications for biomedical image segmentation.
O pensar de Heidegger: notas sobre a história da recepção da filosofia
Authors: Trawny Peter 
Published: February 2021

Tradução de Felipe Maia da Silva e Deborah Moreira GuimarãesEste artigo explicita a problematização da recepção do pensamento de Heidegger e o modo pelo qual a prática filosófica tem sido realizada no ambiente universitário. Trata-se de sustentar a tese de que a grande relevância do pensamento heideggeriano consiste em defender a autonomia do pensar em relação às demais formas de manifestação da existência. Nesse sentido, a História da Filosofia foi consolidada, apesar do que buscamos defender aqui, como uma história de recepções, fortemente determinada pela objetificação do pensar e pela manutenção de estruturas fixas de atuação. Portanto, nosso objetivo é mostrar que a filosofia de Heidegger preserva um importante instrumento de combate à sedimentação do pensamento em obras e à estagnação da atividade filosófica em si mesma.Palavras-chave: Heidegger. História da Filosofia. Recepção filosófica.
Exploring anticancer activity of wild and polyploid mutant of Artemisia cina
Authors: Kasmiyati Sri , Kristiani Elizabeth Betty Elok , Herawati Maria Marina , Rondonuwu Ferdy S 
Published: February 2021

Abstract. Kasmiyati S, Kristiani EBE, Herawati MM, Rondonuwu FS. 2021. Exploring anticancer activity of wild and polyploid mutant of Artemisia cina. Biodiversitas 22: 1227-1234. The research aims were to explore the anticancer compounds in wild type (W) and polyploid mutant (P) of Artemisia cina Berg ex Poljakov using NIR and compare their cytotoxicity and selectivity on WiDR colon cancer and HTB183 lung cancer cell lines and Vero normal cell line. The W was obtained from B2P2TOOT Tawangmangu, Indonesia while P was by inducing A. cina shoot culture with 100 mg/l colchicine for 48 hours. They were extracted with hexane using the soxhletation method for 6 hours. The anticancer compounds were detected using NIR. The cytotoxic activity was determined using MTT assay, with Doxorubicin (D) as a control. The calculation of IC50 value used SPSS16 with a Probit analysis. The P contained the determined four compounds while the W contained no rutin. The IC50 values of W, P, and D were 295.5, 84.1, and 0.5 µg/mL on WiDr, 322.4, 128.6, and 39.9 µg/mL on HTB 183, whereas on Vero were 104, 315.6, and 295.5 µg/mL respectively. The selectivity indexes of W, P, and D were 34, 4, and 91 on WiDr, while HTB 183 was 31, 3, and 7, respectively. The P contained artemisinin, quercetin, kaemferol, and rutin, while the W contained no rutin. The cytotoxicity of both plants was less than doxorubicin. Both plants were selective on WiDR and HTB 183.
Variations of grain physical properties, amylose and anthocyanin of upland red rice cultivars from East Nusa Tenggara, Indonesia
Authors: Markus Jenny E.R. , Ndiwa Antonius S.S. , Oematan Shirly S. , Mau Yosep S. 
Published: February 2021

Abstract. Markus JER, Ndiwa ASS, Oematan SS, Mau YS. 2021. Variations of grain physical properties, amylose and anthocyanin of upland red rice cultivars from East Nusa Tenggara, Indonesia. Biodiversitas 22: 1345-1354. Red rice is becoming more popular nowadays due to the increasing awareness of rice consumers on its health benefits. The demands for red rice are increasing but the supply is limited, thus, local red rice cultivars can be used to fill this gap. Optimal use of local rice germplasm requires a comprehensive evaluation of their traits, and the genotypes having the most desirable traits can be selected for direct use. Several upland red rice cultivars from East Nusa Tenggara Province have been evaluated for various traits while their grain properties are still unrevealed. Information on grain properties is important, both for consumer preference and rice breeders. This study aimed to elucidate the grain physical properties, amylose, and anthocyanin of upland red rice germplasm from ENT Province, and to identify genotypes with the most desirable characters for further employment. Eighteen rice genotypes were used in this study. They were cultivated in the field, and the harvested grains were analyzed in the laboratory. Both ANOVA and descriptive statistics were used for data analysis. Substantial variations were observed on all variables, except the chalky grain percentage. The kernel length of tested genotypes was classified as long, medium, and short while the kernel shapes were slender, medium, and bold. Most tested genotypes had high head rice percentage and low to medium percentages of large and small broken kernels. Chalky grain was almost absent. Amylose content ranged from 1.0% to 28% while anthocyanin was about 1.0 - 20 mg/100 g. The evaluated genotypes were clustered into three main groups. Percentages of large and small broken kernels, and amylose content were mostly responsible for the observed variations among the rice genotypes. The red rice genotypes were diverse in the studied characters, thus, those with desirable grain characters are useful for further development and utilization.