bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN METODE PEMBELAJARAN LEARNING START WITH AQUESTION DALAM MATA PELAJARAN AKIDAH AKHLAK KELAS IX DI MTsAL-AMIEN BUGIH KECAMATAN PAMEKASAN
Authors: Lutfi Muhammad Lutfi Kurniawan , Nawawi Ainul Haq 
Published: September 2021

Abstrak:
Pelaksanaan metode pembelajaran learning start with a questiondalam mata pelajaran akidah akhlak kelas IX yang diterapkan di MTs Al-Amien bugih kecamatan pamekasan. merupakan salah satu metode yang dapat melatih siswa untuk lebih aktif dalam bertanya. Dengan ini siswa dituntut untuk memahami sendiri materi pelajarannya, tanpa dijelaskan oleh guru. Sehingga metode ini dapat merangsang siswa untuk bertanya mengenai hal yang tidak dimengerti tetang materi pelajaran yang akan dipelajari, dan metode ini sangat cocok diterapkan dalam pembelajaran untuk menciptakan siswa yang berani mengemukakan pendapat, berpikir ktritis dan kreatif.
Fokus penelitian ialah penerapan metode learning start with a question dalam mata pelajaran Akidah Akhlak kelas IX dan faktor pendukung dan penghambat dalam menerapkan metode learning start with a question dalam mata pelajaran Akidah Akhlak kelas IX di MTs Al-Amien Bugih Kecamatan Pamekasan.
Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian inkuiri naturalistik.
Hasil penelitian menunjukan bahwa: Pertama,Penerapan metode learning start with a question yang ada pada penelitian ini, yaitu sebelum guru mata pelajaran Akidah Akhlak kelas IX di MTs Al-Amien Bugih Kecamatan Pamekasan memulai pembelajaran, terlebih dahulu guru memberikan materi kepada siswa yang berupa bahan bacaan terkait materi yang akan dipelajari kemudian guru memberikan waktu beberapa menit kepada siswa untuk mempelajari materi yang sudah diberikan, setelah itu guru memerintahkan kepada siswa jika ada materi yang tidak dipahami di catat dan nantik disuruh bertanya apabila sudah sampai waktunya. Setelah siswa selesai bertanya sambil lalu guru menjelaskan materi yangdipelajari dan menjawab pertanyaan-pertanyaan dari siswa dan meluruskan pendapat siswa yang keluar dari materi pembelajaran. Kedua,penerapan proses pembelajaran learning faktor pendukung dan juga penghambatnya ialah siswa siswa mengalami kesulitan untuk memahami pembelajaran sehingga membutuhkan pembiasaan terlebih dahulu dikarenakan belum terbiasa dengan metode pembelajaran seperti ini.
Population Dynamics of Bullet Tuna (Auxis rochei Risso 1881) from the Indian Ocean, West Nusa Tenggara, Indonesia
Authors: Asrial Evron , Khasanah Ruly Isfatul , Fathrurriadi Fathurriadi , Arapat Yasir , Hadi Usma Kurniawan , Kalih Lalu Achmad Tan Tilar Wangsajati Sukmaring , Rizal Lalu Samsul , Liliyanti Mita Ayu , Rosadi Erwin , Setyohadi Daduk , Junaidi Muhammad , Rathnayake Ishani Nelunika 
Published: September 2021

Highlight Research:The bullet tuna (Auxis rochei) was identified and analysed.The length at first maturity (Lm) of bullet tuna (Auxis rochei) was analyzedThe eligibility status of bullet tuna (Auxis rochei) has been analyzed and estimatedThe LWR curve can be used to estimate age groups of fish compared to the sigmoid curveThe CF cannot be automatically used to estimate fish worth selling AbstractThe bullet tuna (Auxis rochei), BLT or tongkol lisong (Indonesian) is a species of neritic tuna which is one of the target fish for small scale fishers. The problem of bullet tuna fisheries was that it has reached overexploitation and the immature bullet tuna are still caught. This study aimed to assess the population dynamics of the BLT and its size composition caught by small scale fishers in the Indian Ocean, West Nusa Tenggara area was carried out in Bangko-Bangko (West Lombok), Cemplung Beach (South Sumbawa) and Tanjung Luar Fishing Port (East Lombok) between July 2019 and June 2020. The data was derived from the measurement and weighing results of 1,217 BLT collected from the respective collector traders at each sampling location. The growth pattern of BLT was isometric () which meant the ideal body shape (mesomorph) and length at first maturity (FLm) was 31.11 cm. The length-weight relationship curve showed that BLT was in an immature age group (adolescent fish). Meanwhile, the composition of BLT is worth selling (Condition Factor > 1.00), fit for catch (FLc / FLm > 1.00) and worthy of maturity (FLc > FLm), respectively 99.92%, 0.82% and 0.00%. The BLT fish composition indicates that the stocks of resources and populations do not support current sustainable fisheries management.
Geostatistical Model for the Arab-D Reservoir, North ’Ain Dar Pilot, Ghawar Field, Saudi Arabia: An Improved Reservoir Simulation Model
Authors: Douglas John L. ,   Members of the ‘Ain Dar/Shedgum Modeling Team
Published: September 2021

ABSTRACT
The North ‘Ain Dar 3-D geocellular model consists of geostatistical models for electrofacies, porosity and permeability for a portion of the Jurassic Arab-D reservoir of Ghawar field, Saudi Arabia. The reservoir consists of a series of shallow water carbonate shelf sediments and is subdivided into 10 time-stratigraphic slices on the basis of core descriptions and gamma/porosity log correlations. The North ‘Ain Dar model includes an electrofacies model and electrofacies-dependent porosity and permeability models. Sequential Indicator Simulations were used to create the electrofacies and porosity models. Cloud Transform Simulations were used to generate permeability models. Advantages of the geostatistical modeling approach used here include: (1) porosity and permeability models are constrained by the electrofacies model, i.e. by the distribution of reservoir rock types; (2) patterns of spatial correlation and variability present in well log and core data are built into the models; (3) data extremes are preserved and are incorporated into the model. These are critical when it comes to determining fluid flow patterns in the reservoir.
Comparison of model Kh with production data Kh indicates that the stratigraphic boundaries used in the model generally coincide with shifts in fluid flow as indicated by flowmeter data, and therefore represent reasonable flow unit boundaries. Further, model permeability and production estimated permeability are correlated on a Kh basis, in terms of vertical patterns of distribution and cumulative Kh values at well locations. This agreement between model and well test Kh improves on previous, deterministic models of the Arab-D reservoir and indicates that the modeling approach used in North ‘Ain Dar should be applicable to other portions of the Ghawar reservoir.
Menstrual hygiene practice and its determinants among Adolescent Girls in Sub-Saharan Africa. A systematic review and meta-analysis protocol
Authors: Anbesu Etsay Woldu , Aychiluhm Setognal Birara 
Published: September 2021

Abstract
Background: Poor menstrual hygiene practices can lead to gynecological problems, psychosocial stress, and reduced access to school. Menstrual hygiene has not received adequate attention in Sub-Saharan Africa. Despite this, there are fragmented and inconsistent findings in Sub-Saharan Africa. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of good menstrual hygiene practice and identify its associated factors among adolescent girls in Sub-Saharan Africa. Methods: The protocol for this review was registered at PROSPERO with registration number: CRD42020165628. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be used to report the protocol. Online electronic databases PubMed, Google Scholar, CINAHL and unpublished grey literature will be searched to retrieve available studies from January 1-May/2021. The selection, data extraction, and quality assessment of studies will be carried by two authors. Joanna Briggs Institute checklist will be used to assess the quality of the studies. Heterogeneity among studies will be examined using a chi-squared test and I-squared statistic. To investigate sources of heterogeneity, subgroup analyses and meta-regression will be done based on region and sample size. Sensitivity analysis will be conducted to identify influential studies. Publication bias will be examined by funnel plots and Egger’s test. The statistical analysis will be conducted using STATA version-14 software. A random-effect model will be used to estimate the pooled prevalence, and statistical significance will be determined at a p-value of <0.05.Discussion: Poor menstrual hygiene practice affects the health of millions of adolescent girls in developing countries. Currently, there are no synthesis research findings on the pooled prevalence of menstrual hygiene practice and its associated factor in Sub-Saharan Africa. Therefore, the findings of this systematic review and meta-analysis will be helpful to inform policy-makers, planners, and researchers to design appropriate interventions.
Prevalence and Incidence of Patients with Fibromyalgia in Catalonia between 2010 and 2017. A Descriptive Observational Study
Authors: Valmaña Glòria Sauch , Catalina Queralt Miró , Vidal-Alaball Josep 
Published: September 2021

Abstract
Background: To measure the prevalence and cumulative incidence of individuals diagnosed with fibromyalgia (FM) in Catalonia between 2010 and 2017. Methods: A retrospective observational study of the population of Catalonia between 2010 and 2017, both included, was designed to describe the incidence, prevalence and sociodemographic characteristics of individuals diagnosed with fibromyalgia. A total of 56,098 patients were included in the study. The scope of the study were the 283 Primary Care Teams (PCT), all managed by the Instituto Catalán de la Salud [Catalan Institute of Health] (ICS). Results: The diagnosis of FM is higher in females (95.4%) than males (4.55%), with a mean age of 53.0 [45.0-61.0] years. The prevalence of FM in the total population was 0.4% in 2010 and 1.4% in 2017. The highest prevalence was found in the 55-65 age group (1.05% in 2010, and 2.46% in 2017). A relationship was found between the prevalence of FM and the degree of socioeconomic deprivation in urban areas: the greater the deprivation, the greater the prevalence of FM. The cumulative incidence of FM in the population remained constant over time (0.11% in 2010 and 0.10% in 2017), being more prevalent in women than men (0.18% women, 0.01% men in 2017).Conclusions: Our study confirms that FM is a prevalent disease in Catalonia, with an upward trend in recent years and it is more prevalent in women.
Investigating the Feasibility of Implementing a Cloud Seeding Project in Sistan and Baluchestan Province, South East of Iran
Authors: Monfared Seyed Arman Hashemi , Poormohammadi Samaneh , Fatemi Mehran , Rasaei Faezeh , Khosravi Mahmood 
Published: September 2021

Abstract
The water shortage is a challenge in many countries around the world. Today, the latest scientific and practical technologies are used to solve the problem of water shortage in arid and semi-arid regions. The optimal use of water resources as well as the use of novel methods of water extraction plays a significant role in alleviating the effects of this crisis. One of the methods used for increasing rainfall and water harvesting from the atmosphere is cloud seeding technology. The first step of this technique involves studying the target area and selecting the appropriate time and place for cloud seeding. The purpose of this study is to investigate the feasibility of cloud seeding in Sistan and Baluchestan province, south east of Iran, for rainmaking. Therefore, using the parameters of precipitation, minimum temperature, relative humidity and cloudy parameter, the status and feasibility for rainmaking in the province were evaluated and suitable months for cloud seeding were determined. Accordingly, December, January, February and March were found to provide suitable conditions for seeding. In order to select suitable places for cloud seeding, zoning maps of precipitation, temperature and relative humidity in selected months as well as the topographic map of the province were prepared by GIS After fuzzyization and integration of these maps, the zoning map of suitable areas for cloud seeding in Sistan and Baluchestan province was drawn to select the most susceptible areas. The area surrounding Khash synoptic station and the southern areas of the province were found to be suitable for cloud seeding.
Transitional Self-Disappear: The Journey of Cancer Survivors to Self Re-Coherence
Authors: Dehghan Mojtaba , Hasani Jafar , Moradi Alireza , Mohammadkhani Shahram 
Published: September 2021

Abstract
Purpose

People who experience cancer often face serious and unpleasant challenges in understanding their past, present, and future. They think they have lost their lifetime, agency, and interpersonal relationships, and no longer know their bodies. These experiences can change survivors' perceptions of themselves. Therefore, the present study aimed to develop a deep theoretical understanding of the change of self in cancer survivors.
Methods

Semi-structured interviews were used to collect data. Interviews were conducted with 17 cancer survivors, 2 oncologists, and 2 family members of survivors. In this study, grounded theory methodology was used to explore the process of understanding and experiencing "self" in cancer survivors.
Results

The present study generated a model about the change of self, with the main concept called "transitional self-disappear", which is understandable based on the concepts of self-disruption (temporal disruption, highlighted body, interference in the agency, - individual-self disruption, over differentiation, relational self-disruption, and painful emotional experiences), self-reconstruction strategy and quality of self-coherence; and occurs in the cancer-based contextual experiences and individual-environmental preparedness.
Conclusion

This model illuminated the complex paths and roads of the survivors' journey from self-disappear to self reconstruction/re-coherence. A healthier experience of this journey can be facilitated by the transcendence of the "self" conceptualized in the past, and the promotion of specific (cancer-based contextual experiences) and general (individual-environmental preparedness) conditions.
FDA-Approved Excipient N,N-Dimethylacetamide Attenuates In-Vitro and In-Vivo Inflammatory Bowel Disease
Authors: Koya Jagadish , Shen Tong , Lu Geming , Gauthier Alex , Mantell Lin , Ashby Charles , Reznik Sandra 
Published: September 2021

Abstract
Background: Inflammatory bowel disease (IBD) affects almost 7 million people worldwide and is increasing in incidence. While the precise pathogenesis of IBD remains unknown, the production of inflammatory cytokines and chemokines play a central role. We have previously found that N,N-dimethylacetamide (DMA), a widely used non-toxic drug excipient, suppresses cytokine and chemokine secretion in vitro and prevents inflammation-induced preterm birth in vivo. Methods: Using sandwich enzyme-linked immunosorbent assays (ELISAs), we tested whether DMA attenuates cytokine and chemokine secretion from LPS- or TNFa-stimulated human intestinal epithelial cells and human monocytes and HMGB1 release from RAW 264.7 cells. To test our hypothesis that the mechanism of DMA’s effects in in-vitro and in-vivo models of IBD is inhibition of the NF-kB pathway, we used western blotting to track levels of the nuclear factor kappa B (NF-kB) inhibitory molecule I kappa B alpha (IkBa) in THP-1 human monocytes in the absence or presence of DMA. Finally, we induced colitis in C57Bl/6 mice with dextran sodium sulfate (DSS) and then tested whether daily i.p injections of DMA at 2.1 g/kg/day attenuates clinical and histopathologic signs of colitis.Results: DMA attenuated cytokine and chemokine release from human intestinal epithelial cells and human monocytes and HMGB1 release from RAW 264.7 cells. Importantly, DMA prevented degradation of IkBa in THP-1 cells, thereby suggesting one mechanism for DMA’s effects. Finally, we show here, for the first time, that DMA attenuates clinical and histologic features of DSS-induced colitis. Conclusion: DMA should be further explored in preclinical and clinical trials for its potential as novel drug therapy for IBD.
SNHG3/miR-148a-3p Axis–mediated High Expression of DNMT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Hepatocellular Carcinoma
Authors: Yao Ninghua , Jiang Wei , Sun Jie , Yang Chen , Zheng Wenjie , Wang Yan 
Published: September 2021

Abstract
Background Epigenetic reprogramming plays an important role in the occurrence, development, and prognosis of hepatocellular carcinoma (HCC). DNA methylation is a key epigenetic regulatory mechanism, and DNA methyltransferase 1 (DNMT1) is the major enzyme responsible for maintenance methylation. Nevertheless, the role and mechanism of DNMT1 in HCC remains poorly defined. Methods In the current study, we conducted pan-cancer analysis for DNMT1’s expression and prognosis using The Cancer Genome Atlas (TCGA) data set. We conducted gene Set Enrichment Analysis (GSEA) between high-and-low DNMT1 expression groups to identify DNMT1-related functional significance. We also investigated the relationship between DNMT1 expression and tumor immune microenvironment, including immune cell infiltration and the expression of immune checkpoints. Through a combination series of computer analyses (including expression analyses, correlation analyses, and survival analyses), the noncoding RNAs (ncRNAs) that contribute to the overexpression of DNMT1 were ultimately identified. Results We found that DNMT1 was upregulated in 16 types of human carcinoma including HCC, and DNMT1 might be a biomarker predicting unfavorable prognosis in HCC patients. DNMT1 mRNA expression was statistically associated with age, histological grade, and the level of serum AFP. Moreover, DNMT1 level was significantly and positively linked to tumor immune cell infiltration, immune cell biomarkers, and immune checkpoint expression. Meanwhile, Gene Set Enrichment Analysis (GSEA) revealed that high-DNMT1 expression was associated with epithelial mesenchymal transition (EMT), E2F target, G2M checkpoint, and inflammatory response. Finally, through a combination series of computer analyses the SNHG3/hsa-miR-148a-3p/DNMT1 axis was confirmed as the potential regulatory pathway in HCC. Conclusion SNHG3/miR-148a-3p axis upregulation of DNMT1 may be related to poor outcome, tumor immune infiltration, and regulated malignant properties in HCC.
PKC Mediates PACSIN2 to Regulate Hypertrophic Cardiomyocytes in the Aggravation of the Compensatory Function
Authors: Wei Siang , Xu Ran , Li Xiaohui , Ding Zhiwen , Zou Yunzeng 
Published: September 2021

Abstract
Background Myocardial hypertrophy (MH) is an independent risk factor for cardiovascular and cerebrovascular events in patients with hypertension and myocardial infarction. Recent studies have shown that PACSIN2 is associated with cardiovascular disease; however, the function of cardiomyocytes remains unclear. Here, the interaction between protein kinase C‎‎ (PKC) and PACSIN2 and the manner in which PACSIN2 regulates MH was studied. Methods The cell models were constructed with angiotensin II (AII) and PMA; qRT-PCR and Western Blot were used to verify the relative protein expression of PKC and PACSIN2; immunofluorescence was used to determine the effect of PKC upregulation on the morphology of hypertrophic cardiomyocytes after an overexpression and silencing of PACSIN2 by qRT-PCR and Western blot analysis. Results The results indicate that PKC positively regulates the expression of PACSIN2 and causes MH phenotype. The overexpression of PACSIN2 was not solely responsible for MH, while the overexpression of PACSIN2 under MH caused hypertrophy to increase. In addition, the high expression of PACSIN2 caused an increase in α-MHC mRNA, but it was not related to the expression of tubulin. The morphological results indicate that the overexpression of PKC causes MH, which causes heart failure. Conclusion Studies have shown that PACSIN2 plays an important role in maintaining myocardial cell contraction and MH. To clarify, the PAC interacting protein and the cardiomyocyte function provide a theoretical basis for the pathology and treatment of hypertrophic cardiomyopathy.
Modeling Relationships Between Iron Status, Behavior, And Brain Electrophysiology: Evidence From a Randomized Study Involving a Biofortified Grain in Indian Adolescents
Authors: Wenger Michael J. , Kolb Laura E. Murray , Scott Samuel P. , Boy Erick , Haas Jere D 
Published: September 2021

Abstract
Background: Iron deficiency (ID) and iron deficiency anemia (IDA) are highly-prevalent nutrient deficiencies and have been shown to have a range of negative effects on cognition and brain function. Human intervention studies including measures at three levels—blood, brain, and behavior—are rare and our objective was to model the relationships among measures at these three levels in school-going Indian adolescents.Methods: Male and female adolescents in rural India were screened for ID/IDA. Subjects consumed 2 meals/day for 6 months; half were randomly assigned to consume meals made from a standard grain (pearl millet) and half consumed meals made from an iron biofortified pearl millet (BPM). Prior to and then at the conclusion of the feeding trial, they completed a set of cognitive tests with concurrent electroencephalography (EEG).Results: Consumption of the BPM resulted in significantly larger improvements (relative to the comparison pearl millet) in the iron biomarkers (mean partial η2 for treatment condition = 0.07), the behavioral variables (mean partial η2 = 0.18), and the EEG variables (mean partial η2 = 0.21). Critically, the best model for the relationship between iron status and cognition had brain measures as a mediating factor, with both serum ferritin as a primary predictor and hemoglobin as a moderator.Conclusions: A dietary intervention involving a biofortified staple grain was shown to be effective in improving blood iron biomarkers, behavioral measures of cognition, and EEG measures of brain function. Modeling the relationships among these variables strongly suggests multiple mechanisms by which blood iron level affects brain function and cognition.Trial registration: Registered at ClinicalTrials.gov: NCT02152150, 02 June 2014.