bluuebunny/crossref_metadata_2025_split huggingface dataset:
What drives continuance intention to use a food-ordering chatbot? An examination of trust and satisfaction
Authors: Hsiao Kuo-Lun , Chen Chia-Chen 
Published: December 2021

PurposeArtificial intelligence (AI) customer service chatbots are a new application service, and little is known about this type of service. This study applies service quality, trust and satisfaction to predict users' continuance intention to use a food-ordering chatbot.Design/methodology/approachThe proposed model and hypotheses are tested using online questionnaire responses to collect users' perceptions of such services. One hundred and eleven responses of actual users were received.FindingsEmpirical results show that anthropomorphism and service quality, such as problem-solving, are the antecedents of trust and satisfaction, while satisfaction has the most significant direct effect on the users' intention.Originality/valueThe results provide further useful insights for service providers and chatbot developers to improve services.
The effect of credit rating downgrades along the supply chain
Authors: Alldredge Dallin M. , Chen Yinfei , Liu Steve , Luo Lan 
Published: December 2021

Purpose
This study aims to examine the information transfer effects of customers’ credit rating downgrades on supplier firms.

Design/methodology/approach
In this study, the authors use suppliers’ cumulative abnormal returns around customers’ credit rating downgrade events to identify how shocks to customer credit impact supplier equity prices. The authors also incorporate ordinary least squares and weighted least squares regressions regression analysis of the determinants of supplier market response to customer downgrades.

Findings
The authors find that customer credit rating downgrades present significant negative shocks to the stock prices of supplier firms. Moreover, the authors show that the information transfer effects are determined by both firm- and industry-level factors, including the market anticipation of downgrades, the strength of the customer–supplier linkage, the industry rivals’ reactions to the downgrades and investor attention. The authors also find that the likelihood that a supplier will receive a rating downgrade is significantly higher following its primary customer firm’s downgrade.

Originality/value
To the best of the authors’ knowledge, this paper is the first to explore the information transfer effects of credit rating downgrades on primary stakeholders within the supply chain. The authors document that customer–supplier networks have valuable implications for the spillover effect across debt and equity holders. Information about customers’ financial stress is incorporated into suppliers’ equity prices outside of the context of customer bankruptcy.
Business process prioritization criteria: a case study in the financial market
Authors: Santos Robson Porfírio dos , Salgado Thaiane Martins , Pereira Veridiana Rotondaro 
Published: December 2021

Purpose
This paper aims to analyze and examine how an organization from the financial sector prioritizes its business processes and what criteria are adopted to select the most appropriate process for improvement projects.

Design/methodology/approach
This descriptive research is based on an exploratory approach. Qualitative methodology was applied to a case study through on-site observation, documentation analysis and semi-structured interviews.

Findings
The results confirm criteria mentioned in the literature, such as financial aspects and strategic impacts, but also raised a new critical issue: automation potential of manual processes, reflecting the current movement of process automation.

Research limitations/implications
As a limitation of this study, it is worth mentioning the application in only one organization in the financial market and the small number of respondents, even though they occupy leadership positions in the organization.

Practical implications
As a practical implication, the present work offers a direction for managers of the financial sector in structuring and applying models for prioritizing processes aimed at organizational efficiency.

Social implications
Automation solutions for process improvement need careful study to minimize impacts in human resources reduction. In this sense, the eligibility of a process for automation must be carefully considered.

Originality/value
This paper presents the evolution of the process prioritization model adopted by a large institution in the financial market, which has a significant presence in the Brazilian and international markets as a commercial and wholesale bank.
Estimation of total fine root production using continuous inflow methods in tropical mangrove forest on Pohnpei Island, Micronesia: Fine root necromass accumulation is a substantial contributor to blue carbon stocks
Authors: Ono Kenji , Fujimoto Kiyoshi , Hirata Yasumasa , Tabuchi Ryuichi , Taniguchi Shingo , Furukawa Keita , Watanabe Shin , Suwa Rempei , Lihpai Saimon 
Published: December 2021

AbstractFine root decomposition, mortality, and production are fundamental components of belowground carbon dynamics in mangrove ecosystems. Mangroves are highly productive ecosystems with huge carbon stocks; however, information on the dynamics of submerged fine roots in mangrove soils is limited. To estimate fine root production in several sites of mangrove communities on Pohnpei Island, Micronesia, we estimated continuous inflows using a simple mass balance model to combine ingrowth core and litterbag experimental results. According to our findings, previously reported mangrove fine root production values were severely underestimated because the fine root decomposition process was disregarded during the experimental period. We estimated that annual fine root production up to 0.3 m in depth ranged from 13.8 (Bruguiera gymnorrhiza in a landward plot) to 56.3 Mg ha−1 year−1 (B. gymnorrhiza in a seaward plot). However, comparing the fine root production with respect to the unit of stem cross‐section area increase in the sample tree, the fine root production of Rhizophora spp. was greater than that of other species. The annual fine root mortality and decomposition to annual fine root production was 70%–105% and 11%–52% of annual production, respectively. The annual fine root production estimated here was much higher than that previously reported. These findings begin to quantify the contribution and importance of highly productive mangrove fine roots for carbon sequestration in blue carbon ecosystems. Moreover, this study provides new insights into the organic carbon dynamics in mangrove soils with mangrove vegetation succession.
Sudden death related to the gastrointestinal system in Tunisia: A 13 year autopsy study
Authors: Ben Abderrahim Sarra , Gharbaoui Meriem , Békir Olfa , Hamdoun Moncef , Allouche Mohamed 
Published: December 2021

AbstractSudden gastrointestinal (GI) death is an unexpected death due to digestive system causes mainly found after autopsy. The literature is rich in articles that studied sudden death due to cardiac causes while sudden GI deaths remain less well‐documented. We retrospectively investigated all cases of gastrointestinal death at the Department of Forensic Medicine in Tunis, over 13 years (January 1, 2006 to December 31, 2018). Two hundred and eight cases were collected. The mean age of our series was 51.06 ± 20.99 years. No history of digestive disorders was reported in 78.4%, and no family history of sudden death was found in any cases. A male predominance was found in most epidemiological characteristics of the sample with a significant statistical rate in some features. Non‐specific abdominal pain was the most described symptom (n = 92). Perforation of GI tract was the common mechanism involved in the death of 55 cases, of which 44 were related to ulcer perforation. These ulcer perforations were statistically more reported in smokers and people suffering from schizophrenia. Intestinal obstruction was the second commonest cause of death, mainly found in the elderly. Sudden death in children was most frequently caused by acute intussusception. This study highlights that systematic study of sudden death due to GI causes might provide opportunities to identify avenues for overall health improvement.
Update on adjuvant therapy in completely resected NSCLC patients
Authors: Lim Jeong Uk , Yeo Chang Dong 
Published: December 2021

AbstractIn patients with completely resected non‐small cell lung cancer (NSCLC), postoperative adjuvant chemotherapy has been associated with improvement in survival by minimizing the risk of recurrence. For years, systemic chemotherapy including platinum based regimen has been a mainstay treatment modality of adjuvant treatment after complete resection. ADAURA study showed that among completely resected IB to IIIA NSCLC, disease‐free survival was significantly better in patients under adjuvant osimertinib than a placebo group. After the advent of a variety of new treatment regimens, such as third generation TKI and immunotherapy, the landscape of postoperative adjuvant treatment has been changing. In this review, we discuss some key issues regarding choice of adjuvant treatment after complete resection in NSCLC, and provide further updates on recent advances in treatment modalities.
Differential responses of amphibians and reptiles to land‐use change in the biodiversity hotspot of north‐eastern Madagascar
Authors: Fulgence T. R. , Martin D. A. , Randriamanantena R. , Botra R. , Befidimanana E. , Osen K. , Wurz A. , Kreft H. , Andrianarimisa A. , Ratsoavina F. M. 
Published: December 2021

AbstractLarge expanses of tropical rainforest have been converted into agricultural landscapes cultivated by smallholder farmers. This is also the case in north‐eastern Madagascar; a region that retains significant proportions of forest cover despite slash‐and‐burn shifting hill rice cultivation and vanilla agroforestry expansion. The region is also a global hotspot for herpetofauna diversity, but how amphibians and reptiles are affected by land‐use change remains largely unknown. Using a space‐for‐time study design, we compared species diversity and community composition across seven prevalent land uses: unburned (old‐growth forest, forest fragment, and forest‐derived vanilla agroforest) and burned (fallow‐derived vanilla agroforest, woody fallow, and herbaceous fallow) land‐use types, and rice paddy. We conducted six comprehensive, time‐standardized searches across at least 10 replicates per land‐use type and applied genetic barcoding to confirm species identification. We documented an exceptional diversity of herpetofauna (119 species; 91% endemic). Observed plot‐level amphibian species richness was significantly higher in old‐growth forest than in all other land‐use types. Plot‐level reptile species richness was significantly higher in unburned land‐use types compared with burned land‐use types. For both amphibians and reptiles, the less‐disturbed land‐use types showed more uneven communities and the species composition in old‐growth forest differed significantly from all other land‐use types. Amphibians had higher forest dependency (38% of species occurred exclusively in old‐growth forest) than reptiles (26%). Our analyses thus revealed that the two groups respond differently to land‐use change: we found less pronounced losses of reptile species richness especially in unburned agricultural habitats, suggesting that reptiles are less susceptible to land‐use change than amphibians, possibly due to their ability to cope with hotter and drier microclimates. In conclusion, our findings emphasize existing conservation opportunities – especially for reptiles – in extensive agricultural landscapes while highlighting the precarious situation of amphibians in disappearing old‐growth forests.
Frequency of DPYD gene variants and phenotype inference in a Southern Brazilian population
Authors: Botton Mariana Rodrigues , Hentschke‐Lopes Marina , Matte Ursula 
Published: December 2021

AbstractFluoropyrimidines are chemotherapy drugs that may cause severe adverse events, and their metabolism occurs by dihydropyrimidine deydrogenase (DPD), coded by DPYD. Variants in the DPYD were associated to a greater risk of toxicity. Our aim was to determine the frequency of the most relevant DPYD alleles according to CPIC guidelines (DPYD*2A‐rs3918290, DPYD*13‐rs55886062, rs67376798, and HapB3‐rs75017182) in a sample of 800 healthy Southern Brazilians. Frequencies for rs3918290, rs75017182, and rs67376798 were 0.25%, 1.06%, and 0.38%, respectively. No rs55886062 allele was detected. In total, 3.4% of individuals were classified as intermediate metabolizers. Frequencies for rs3918290, rs55886062, and rs67376798 were similar to those found in non‐Finnish Europeans; however, rs75017182 was less frequent when compared to non‐Finnish Europeans, but more frequent than in Africans and East Asians. rs3918290 and rs67376798 also presented higher frequency when compared to Africans. The Latino population was the only one that did not differ from our sample in any variant analyzed. The frequencies for all the other populations (non‐Finnish European, African, South Asian, and East Asian) presented differences from our sample in at least one variant. rs115232898 was not analyzed in the present study. Cost‐effective studies should be performed to evaluate the implementation of these tests in the clinical practice in the Southern Brazil.
Two internal critiques for theists who oppose moral enhancement on a process virtue basis
Authors: Brummett Abram , Crutchfield Parker 
Published: December 2021

AbstractSome bioconservatives reject the use of biotechnology for moral enhancement while simultaneously purporting to accept standard theism and process virtue. Standard theism holds that God is a personal, omniscient, omnibenevolent, omnipotent, transcendent being. Process virtue holds that virtue can only be obtained through a specific process and not by means of biotechnological shortcuts. For example, proponents of the view may claim that the virtue of compassion cannot be achieved by taking a pill but must come about from organic life experience that involves suffering, and reflection. We describe two internal critiques that arise by combining standard theism and process virtue. The first critique arises when the process virtue view is applied to the concept of God himself. Because God is thought to have always been perfectly virtuous, it follows he did not obtain his virtue through a process. Theistic bioconservatives must either give up the notion that God has always been perfectly virtuous or give up their claim that virtue must be obtained through a particular kind of process. The second critique argues that rejecting moral enhancement on the basis of process virtue is selfish, which is a vice by the lights of all mainstream manifestations of standard theism. Process virtue is selfish because it requires prioritizing the development of one's own personal virtue over moral enhancement that will improve one's other‐regarding virtues. We conclude that the combination of standard theism and process virtue does not serve as a strong basis from which to oppose moral enhancement.
Elevational distribution of birds in an Eastern African montane environment as governed by temperature, precipitation, and habitat availability
Authors: van der Hoek Yntze , Sirami Clélia , Faida Emmanuel , Musemakweli Valens , Tuyisingize Deogratias 
Published: December 2021

AbstractTropical species, many of which have limited thermal tolerances and narrow ecological niches, are likely to experience elevational shifts due to climate change. However, our ability to predict these shifts is limited by a scarcity of baseline data on current distributions and a lack of understanding of drivers of species ranges. To characterize the elevational distributions of a suite of Afromontane birds, we conducted annual point counts between 2013 and 2018 at 297 plots across habitats and elevations (2416–4303 m) in Volcanoes National Park, Rwanda. We assessed elevational and habitat preferences via indicator analyses, and modeled abundance distributions as a function of temperature, precipitation, habitat availability, and congeneric competition. Although most of the 35 focal species were distributed across habitats and elevational ranges, 20 species particularly associated with narrow elevational range (<300 m) and 24 species were strongly associated with one to three habitat types. Abiotic factors significantly correlated with abundance distributions of 33 species (temperature 33, precipitation 17), and biotic factors with distributions of 31 species (habitat 30, competition 7). Temperature and habitat availability were particularly associated with upper elevational limits (31 and 26 species, respectively, vs. 10 and 6 at lower limits), whereas precipitation affected both limits similarly (17 lower, 16 upper), and competition had a limited role at either limit (4 lower, 3 upper). That the elevational distribution of Afromontane birds results from a species‐specific combination of biotic and abiotic factors is crucial information in our effort to predict climate change effects in this region.
RUNX1 transactivates BCR‐ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia
Authors: Masuda Tatsuya , Maeda Shintaro , Shimada Sae , Sakuramoto Naoya , Morita Ken , Koyama Asami , Suzuki Kensho , Mitsuda Yoshihide , Matsuo Hidemasa , Kubota Hirohito , Kato Itaru , Tanaka Kuniaki , Takita Junko , Hirata Masahiro , Kataoka Tatsuki R , Nakahata Tatsutoshi , Adachi Souichi , Hirai Hideyo , Mizuta Shuichi , Naka Kazuhito , Imai Yoichi , Kimura Shinya , Sugiyama Hiroshi , Kamikubo Yasuhiko 
Published: December 2021

AbstractThe emergence of tyrosine kinase inhibitors as part of a front‐line treatment has greatly improved the clinical outcome of the patients with Ph+ acute lymphoblastic leukemia (ALL). However, a portion of them still become refractory to the therapy mainly through acquiring mutations in the BCR‐ABL1 gene, necessitating a novel strategy to treat tyrosine kinase inhibitor (TKI)‐resistant Ph+ ALL cases. In this report, we show evidence that RUNX1 transcription factor stringently controls the expression of BCR‐ABL1, which can strategically be targeted by our novel RUNX inhibitor, Chb‐M'. Through a series of in vitro experiments, we identified that RUNX1 binds to the promoter of BCR and directly transactivates BCR‐ABL1 expression in Ph+ ALL cell lines. These cells showed significantly reduced expression of BCR‐ABL1 with suppressed proliferation upon RUNX1 knockdown. Moreover, treatment with Chb‐M' consistently downregulated the expression of BCR‐ABL1 in these cells and this drug was highly effective even in an imatinib‐resistant Ph+ ALL cell line. In good agreement with these findings, forced expression of BCR‐ABL1 in these cells conferred relative resistance to Chb‐M'. In addition, in vivo experiments with the Ph+ ALL patient‐derived xenograft cells showed similar results. In summary, targeting RUNX1 therapeutically in Ph+ ALL cells may lead to overcoming TKI resistance through the transcriptional regulation of BCR‐ABL1. Chb‐M' could be a novel drug for patients with TKI‐resistant refractory Ph+ ALL.
The neural correlates of working memory training in typically developing children
Authors: Jones Jonathan S. , Adlam Anna‐Lynne R. , Benattayallah Abdelmalek , Milton Fraser N. 
Published: December 2021

AbstractWorking memory training improves children's cognitive performance on untrained tasks; however, little is known about the underlying neural mechanisms. This was investigated in 32 typically developing children aged 10–14 years (19 girls and 13 boys) using a randomized controlled design and multi‐modal magnetic resonance imaging (Devon, UK; 2015–2016). Training improved working memory performance and increased intrinsic functional connectivity between the bilateral intraparietal sulci. Furthermore, improvements in working memory were associated with greater recruitment of the left middle frontal gyrus on a complex span task. Repeated engagement of fronto‐parietal regions during training may increase their activity and functional connectivity over time, affording greater working memory performance. The plausibility of generalizable cognitive benefits from a neurobiological perspective and implications for neurodevelopmental theory are discussed.
International differences in the CEO gender pay gap
Authors: Chen Xiaoqi , Torsin Wouter , Tsang Albert 
Published: December 2021

AbstractResearch question/issueThis study examines (i) whether and to what extent differences in the level of compensation paid to men and women can be observed at the corporate executive (i.e., CEOs) level in an international setting and (ii) whether and how country‐level attitudes toward gender equality help explain the heterogeneity in the CEO gender pay gap observed across countries.Research findings/insightsUsing executive compensation data from 27 countries over the 2001–2016 period, this study documents a 3.3% average difference in the level of executive compensation between male and female CEOs in countries around the world. The results further indicate that firms that transition from a male to a female CEO tend to have a significantly lower level of compensation. These results are robust when controlling for an array of key CEO attributes including education, age, and work experience and when US firms are excluded from the sample. Our findings also suggest that attitudes related to gender equality across countries can be an important factor explaining the CEO gender pay gap observed in our study.Theoretical/academic implicationsThe results of our study suggest the existence of a CEO gender pay gap at the international level. Specifically, our study suggests that the difference in pay between men and women, which is well documented in the literature of many countries, not only applies to regular employees in an economy but can also be generalized to those who work at the chief executive level. More importantly, our study suggests that a country's institutional environment vis‐à‐vis gender equality can contribute to the gender pay differences observed in various countries around the world.Practitioner/policy implicationsWe provide evidence supporting the existence of a gender pay gap using executive compensation data at the CEO level. We further show that country‐level institutional characteristics related to gender equality partly contribute to gender pay differences between male and female CEOs across countries. Thus, the findings of our study provide new insights into the potential determinants of executive compensation (i.e., CEO gender and country‐level gender equality) and are valuable to policymakers in proposing legislative changes to reduce the gender pay gap.