bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-Cavitary Fluid Resulted From Caesarean Section But Not Isthmocele Compromised Clinical Pregnancy After IVF/ICSI Treatment
Authors: Meihong Cai , Pan Xinyi , Xia Wei , Liang Xiaoyan , Yang Xing 
Published: September 2021

Abstract
The aim of this study was to explore whether the presence of intra-cavitary fluid (ICF) influences the pregnancy outcomes of patients with caesarean section (CS) in embryo transfer cycles. A total of 8494 transferred cycles of 4924 women were enrolled in this retrospective study and separated into three subgroups by previous delivery method and the presence of intra-cavity fluid, a caesarean group with ICF (CS-ICF, n=649), a caesarean group without ICF (CS-noICF, n=3207) and the remaining 4638 cycles without ICF were included in the vaginal delivered group (VD, n=4638). Baseline characteristics and clinical outcome were compared. Propensity score matching (PSM) was conducted to adjust confounding factors between groups. Patients in the CS-ICF group were of younger age (36.49±4.19 vs 37.34±4.25, 37.32±4.86, P<0.001), had better ovary reserve and had more blastocyst transferred compared with the CS-noICF and VD groups. However, cycles in the CS-ICF group achieved unsatisfactory clinical pregnancy outcomes. PSM analysis for comparability, differences in clinical outcomes still existed. The clinical pregnancy rate was significantly lower in the CS-ICF group than in the CS-noICF group (35.1% vs 41.7% for CS-noICF group, 48.1% for VD group, P<0.001). Subgroup analysis of fresh embryo transferred cycles, the differences in clinical outcomes disappeared after PSM analysis, while the clinical pregnancy rate was still lowest among the three matched group of FET cycles (36.4% vs 50.3% for VD group, P<0.001). The presence of intra-cavitary fluid (ICF), but not necessarily the isthmocele, significantly compromises the clinical pregnancy rate in patients with previous CS undergoing IVF/ICSI treatment.
Enhanced UV Direct Photolysis And UV/H2O2 For Oxidation of Triclosan And Ibuprofen In Synthetic Effluent: An Experimental Study
Authors: Luz Vilson Conrado da , Bazoti Suzana Fatima , Behling Laura , Rosa Clarissa Dalla , Pasquali Gean Delise Leal 
Published: September 2021

Abstract
This study aimed to evaluate the implementation of an advanced oxidation system based on UV radiation and UV/H2O2 for degradation of TCS and IBU in synthetic effluent. The assays occurred in a 2L reactor, protected from external light and equipped with a UV lamp (λ = 254nm). The effect of contaminant concentration, fractions of chemical species present, and mineralization were evaluated. In the UV/ H2O2 system, different concentrations of H2O2 were studied for oxidation of the contaminants. The kinetic experiments took place between 75 - 270 min of UV irradiation. The results showed > 99% oxidation of TCS in the direct photolysis system at pH 9.4 after 12 min. The degradation of IBU in the UV/H2O2 system, when 10mg L-1 of H2O2 was used, obtained 97.39% oxidation. We obtained k' values of 0.189 min-1 for TCS when its highest oxidation occurred, and k' values of 0.0219 min-1 for IBU. The system was not able to completely mineralize the contaminants, presenting high values of TOC and COD after treatment, thus suggesting the occurrence of phototransformation.
WITHDRAWN: Is Exposure to PM2.5 and PM10, a Factor of Surge of 2nd Wave of COVID-19- A Case Study of Delhi, India?
Authors: Shukla Avnish , Mishra Anirudh , Tandel Bhaven Nirmalbhai Tandel 
Published: September 2021

Abstract
Exposure to air pollutants cause severe health issues. Restriction onmajor activities induced by government improves the air quality during the lockdown due to Covid-19 pandemic. Investigation of correlation of high level of Severe Acute Respiratory Syndrome Coronavirus2 and its mortality rate with ground level particulate matter concentration was carried out in this study during the second wave of covid-19 in the megacity Delhi, India. Daily average concentration of major two fractions of particulate matter PM2.5 and PM10 were analyzed for the period of 22 March 2021 to 15 May 2021 that grouped into two categories before lockdown and during lockdown. Results revealed that overall reduction of 1.6% in PM2.5 concentration and 15% in PM10 concentration was observed on imposing the lockdown and significant reduction in Particulate Matter concentration was observed for most of the locations for the lockdown period as compared to before lockdown period. Furthermore daily new Covid-19 cases and its death rate was found negatively associated (very weak correlation) with the ground level concentration of PM2.5 and PM10 i.e. before lockdown period while positive association (moderately correlated) was noticed among the daily new Covid-19 cases, its death rate, ground level concentration of PM2.5 and PM10 in time period of lockdown. This Study revealed that the high degree of atmospheric contamination in Northern India can be deemed an external co-factor in the area's high mortality and high positivity rate during the second wave Covid19 pandemic.
The Best and the Worst: TEFL Experts' Opinions of the Most and the Least Important Predictors of Situational Willingness to Communicate
Authors: Rafiee Marzieh , Naghneh Salman Abbasian 
Published: September 2021

Abstract
The current study aimed to identify the most and the least important situational properties of second language willingness to communicate (L2WTC) in an EFL context. After reviewing the related literature, 24 influencing factors were identified and then they were prioritized. Ninety TEFL experts participated in the study to answer the research questionnaire. A quantitative research approach applying paired comparison questionnaire was employed. Data analysis was done using Excel spreadsheet for sorting data and calculating the mean and WinQSB software for solving linear programming model. The results showed that, among the selected variables, "the size of the group", "familiarity with topics under discussion", and "interlocutors and familiarity with them" were determined to be the first most important situational variables which highly influence L2WTC. The findings also showed that "attitudes toward the learning situation", "course evaluation criteria" and "alignment with the classroom norms" were the least important factors influencing L2WTC. The significance of the study lies in its theoretical contributions and pedagogical implications it has for the field of second language teaching and learning.
An Observer Tool for to Enhance Learning of Anesthesia Resident’s Non-Technical Skills During High-Fidelity Simulation: A Randomized Controlled Trial
Authors: Blanié Antonia , Arcile Gauthier-Charles , Roulleau Philippe , Benhamou Dan 
Published: September 2021

Abstract
Background: An observer tool (OT) dedicated to technical skills could improve learning of medical knowledge during simulation. However, it remains uncertain whether non-technical skills learning outcomes might be improved by using an OT.Methods: After consent, anesthesia residents enrolled to a crisis management training simulation were randomized to use an observer tool (OT +) (based on non-technical skills) or not (OT-) when not role-playing. The main outcome parameter was non-technical skills learning outcomes assessed by the global score of non-technical skills learning after the training (self-assessment using the 15 items of 4 categories of the Anaesthetists’ Non-Technical Skills (ANTS); 0 to 10 Likert scale; /40). The perceived stress level, satisfaction and the score of medical knowledge were also assessed. Results: All anesthesia residents were randomized (n = 48; OT+ group, n = 37; OT- group). At the end of the session, the global score of ANTS learning and the medical knowledge score were similar in the two groups: 31 ± 4 (OT+) and 31 ± 5 / 40 (OT-) (p = 0.55) and 12 ± 2 (OT+) and 12 ± 2 / 20 (OT-) (p=0.47). The 2 groups had a positive and similar perception of learning stress management, improvement of crisis skills management, satisfaction and changes in professional practice after the training session.Conclusions: This study has shown a positive perception of ANTS learning after crisis training without difference between using or not an OT in anesthesia residents. More studies are necessary to define the place of this educational tool. Trial registration: researchregistry.com. Registration number: researchregistry7055. Retrospectively registered August 13, 2021.
The “Seili-index” For The Prediction of Chlorophyll-α Levels In The Archipelago Sea of The Northern Baltic Sea, Southwest Finland
Authors: Hänninen Jari , Mäkinen Katja , Nordhausen Klaus , Laaksonlaita Jussi , Loisa Olli , Virta Joni 
Published: September 2021

Abstract
To build a forecasting tool for the state of eutrophication in the Archipelago Sea, we fitted a Generalized Additive Mixed Model (GAMM) to marine environmental monitoring data, which were collected over the years 2011-2019 by an automated profiling buoy at the Seili ODAS-station. The resulting “Seili-index” can be used to predict the chlorophyll-α (chl-a) concentration in the seawater a number of days ahead by using the temperature forecast as a covariate. An array of test predictions with two separate models on the 2019 data set showed that the index is adept at predicting the amount of chl-a especially in the upper water layer. The visualization with 10 days of chl-a level predictions are presented online at https://saaristomeri.utu.fi/seili-index/. We also applied GAMMs to predict abrupt blooms of cyanobacteria on the basis of temperature and wind conditions and found the model to be feasible for short-term predictions. The use of automated monitoring data and the presented GAMM model in assessing the effects of natural resource management and pollution risks is discussed.
Tillage, Green Manure And Residue Retention Improve Aggregate-Associated Phosphorus Fractions Under Rice-Wheat Cropping
Authors: Sharma Sandeep , Kaur Sukhjinder , Choudhary Om Parkash 
Published: September 2021

Abstract
The sustainability of rice-wheat system (RWS) in north-western India is threatened due to the deterioration of soil health and emergence of new challenges of climate change caused by low nutrient use efficiency and large scale burning of crop residues. Phosphorus and phosphatase activities in the soil aggregates affected by different residue management practices remain poorly understood. Thus, soil samples were obtained after a five year field experiment to identify the effect of tillage, green manure and residue management on aggregate-associated phosphorus fractions. In rice, the main plot treatments were combinations of wheat straw and Sesbania green manure (GM) management: (1) puddled transplanted rice (PTR) with no wheat straw (PTRW0), (2) PTR with 25% wheat stubbles (12-15 cm long) retained (PTRW25), (3) PTR without wheat straw and GM (PTRW0+GM), and (4) PTR with wheat stubbles (25%) and GM (PTRW25+GM). Three sub-plots treatments in the successive wheat crop were (1) conventional tillage with rice straw removed (CTWR0), (2) zero tillage (ZT) with rice straw removed (ZTWR0) and (3) ZT with 100% rice straw retained as surface mulch (ZTWR100). Results of the present study revealed that all phosphorus fractions were significantly higher in PTRW25+GM followed by ZTWR100 compared with PTRW0/CTWR0 treatment within both macro- and micro-aggregates. The total phosphorus (P), available P, alkaline phosphatase and phytin-P were significantly higher under ZTWR100 than CTWR0. Principal component analysis identified NaOH-Po, NaHCO3-Pi and HCl-P as the dominant and reliable indicators for evaluating P transformation within aggregates under conservation agriculture based practices.
Protective Effect of Calcium Dobesilate Administration Against Hepatorenal Damage Induced By CCL4 In Male Mice
Authors: Hakimizadeh Elham , Kaeidi Ayat , Rahmani Mohammadreza , Allahtavakoli Mohammad , Hassanshahi Jalal 
Published: September 2021

Abstract
Purpose: Calcium dobesilate (CaD) has antioxidant and anti-inflammatory properties. In this study, the protective effects of CaD against hepatorenal damage induced by CCL4 in male mice were evaluated. Methods: Thirty male mice randomly were divided into five groups: Control, CaD 100 mg/kg, CCL4, CCL4+CaD 50 mg/kg, and CCL4+CaD 100 mg/kg. Drugs were administered orally once a day for 4-weeks. The liver and kidney indices (serum creatinine, blood urine nitrogen, alanine aminotransferase and aspartate aminotransferase levels) were determined. Also, hepatic and renal tissue oxidant/antioxidant markers (glutathione peroxidase, malondialdehyde, total antioxidant capacity, and superoxide dismutase) were measured. Cleaved caspase-3, Bax, and Bcl-2 protein levels were measured by immunoblotting method. The liver and kidney histopathological changes were evaluated by H&E staining.Results: CCL4 induces significant oxidative stress in the kidney and liver that was concomitant with functional and histopathological abnormalities in these organs in the CCL4 group versus the control (P<0.05). CaD could significantly improve the histopathological change in the liver and kidney tissues of CCL4+CaD 100 mg/kg mice versus the CCL4 group (P<0.05). In addition, CaD attenuated apoptosis in the liver and kidney tissues (P<0.05).Conclusion: The protective effect of CaD may be related to its anti-inflammatory and antioxidant properties.
Clinical Outcomes of Nicorandil Administration In Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Systematic Review And Meta-Analysis of Randomized Controlled Trials
Authors: Geng Ning , Ren Li , Xu Lisheng , Zou Deling , Pang Wenyue 
Published: September 2021

Abstract
Background: Primary percutaneous coronary intervention is the treatment of choice in ST-segment elevation myocardial infarction and no-reflow phenomenon is still an unsolved problem.Methods: We searched PubMed, EmBase, and Cochrane Central Register of Controlled Trials for relevant randomized controlled trials. The primary endpoint was the incidence of major adverse cardiac events and the secondary endpoint was the incidences of no-reflow phenomenon and complete resolution of ST-segment elevation. Results: Eighteen randomized controlled trials were enrolled. Nicorandil significantly reduced the incidence of no-reflow phenomenon (OR, 0.46; 95% CI, 0.36 to 0.59; P＜0.001; I2=0%) and major adverse cardiac events (OR, 0.42; 95% CI, 0.27 to 0.64; P＜0.001; I2=52%). For every single outcome of major adverse cardiac events, only heart failure and ventricular arrhythmia were significantly improved with no heterogeneity (OR, 0.36; 95% CI, 0.23 to 0.57, P＜0.001; OR, 0.43; 95% CI, 0.31 to 0.60, P＜0.001 respectively). A combination of intracoronary and intravenous nicorandil administration significantly reduced the incidence of major adverse cardiac events with no heterogeneity (OR, 0.24; 95% CI, 0.13 to 0.43, p＜0.001), while a single intravenous administration could not (OR, 0.66; 95% CI, 0.40 to 1.06, p=0.09; I2=52%). Conclusions: Nicorandil can significantly improve no-reflow phenomenon and major adverse cardiac events in patients undergoing primary percutaneous coronary intervention. The beneficial effects on major adverse cardiac events might be driven by the improvements of heart failure and ventricular arrhythmia. A combination of intracoronary and intravenous administration might be an optimal usage of nicorandil.
The Role of Endogenous Carbon Monoxide (CO) on Functioning of Biological Clock in Pig and Wild Boar Hybrid During Long and Short Day Season
Authors: GILUN Przemysław , Wąsowska Barbara , Sowa-Kućma Magdalena , Kozioł Katarzyna , Romerowicz-Misielak Maria , Koziorowski Marek , Koziorowska-Gilun Magdalena 
Published: September 2021

Abstract
Bacground: The master biological clock (pacemaker) is located in the suprachiasmatic nuclei (SCN) of the preoptic part of the hypothalamus (POA) and makes organisms adjust to the rhythms, both annual and circadian. Intrinsic pacemaker function is based on the 24-hour oscillator of the transcription factor genes Bmal1/Clock or its paralog Npas2 in which an E-box-bound heterodimeric transcription factor drives the expression of Per 1-2, Cry 1-2 and Rev-erb α-β (NR1D1 and NR1D2) genes. The main factor that influences the functioning of this clock rhythm is the light signal reaching the SCN from the retina via the neural pathway, the so-called non-forming image signal. On the other hand, endogenous carbon monoxide (CO) whose formation and availability depends on the amount of light is a chemical signal delivered through the humoral pathway independently of the neural signal. The aim of this experiment was to demonstrate that chemical light carrier CO, regulates the expression of biological clock genes via humoral pathways. Mature males of a wild boar-pig crossbreed, during long and short day season, were used for the study. Autologous blood with experimentally elevated concentrations of endogenous CO (using lamps with white light-emitting diodes) was infused into ophthalmic venous sinus via the right dorsal nasal vein.Results: The results showed that elevated endogenous CO levels through blood irradiation induces changes in genes expressioninvolved in functioning of the major biological clock. Changes in the expression of the transcription factors Bmal1, Clock and Npas2 have a similar pattern in both structures where a very large decrease in gene expression was shown after exposure to elevated endogenous CO levels. The changes in the gene expression of Per 1-2, Cry 1-2, and Rev-erb α-β and Ror β are not the same for both POA and DH structures indicating that both structures respond differently to the received humoral signal.Conclusion: Obtained results indicate that CO is a chemical light molecule whose production in organism depends on the amount of light. An adequate amount of light is an essential factor for the proper functioning of the internal biological clock which is a regulator of many important physiological processes.
Geospatial characterization of immune cell distributions and dynamics across the microenvironment in renal cell carcinoma
Authors: Chakiryan Nicholas , Kim Youngchul , Berglund Anders , Kimmel Gregory , Chang Andrew , Hajiran Ali , Nguyen Jonathan , Moran Carlos , Saeed-Vafa Daryoush , Katende Esther , Lopez-Blanco Neale , Chahoud Jad , Rappold Phillip , Spiess Phillip , Fournier Michelle , Jeong Daniel , Wang Liang , Du Dongliang , Teer Jamie , Dhillon Jasreman , Hakimi Ari , Altrock Phillip , Mule James , Manley Brandon 
Published: September 2021

Abstract
We performed multiplex immunofluorescence (mIF) using an array of myeloid and lymphoid markers on primary tumor samples from 122 patients with RCC. Regions of interest (ROIs) were selected from three distinct tumor zones: the tumor-core, stroma, and tumor-stroma interface. Digital pathologic imaging analysis was leveraged to quantify the geospatial location and distribution of immune cells within the TIME, and these findings were correlated with a variety of tumor molecular profiles. For patients with ccRCC, as clinical stage increased, immunosuppressive M2-like CD163+ TAMs migrated from the tumor compartment and into the stroma at the tumor-stroma interface and became increasingly co-localized with CD8+ T-cells. Furthermore, high CD163+ TAM clustering into the stromal compartment and high CD8+/CD163+ stromal co-localization were independently associated with worse OS and cancer-specific survival (CSS), while accounting for clinical stage. Overall, this data suggests that the pro-tumor effect of M2-like TAMs and their effect on CD8+ T-cells may be dependent on their specific geospatial location and distribution within the TIME -- namely, that M2-like TAMs exert their pro-tumor effect and interact with CD8+ T-cells most effectively from the stromal compartment at the tumor-stroma interface.
Unit Price of Manufacturing Exports that Process Natural Resources From Latin America.
Authors: Fujii-Gambero Gerardo , Morales-López Rodrigo 
Published: September 2021

Abstract
Lead-inWe explore the potential domestic income increase in Latin American exports following unit prices of exported products by processing stage.In various developed countries, manufacturing began through the internal processing of locally available natural resources. Currently, high-income countries participate in world trade by exporting these types of products. The objective of this paper is to demonstrate the level of sophistication of these exports by monitoring the unit price of exports of the petrochemical chain (Argentina, Brazil, Mexico, and Venezuela); copper (Chile and Peru); iron and steel (Brazil and Mexico); and soybean and its derivatives (Argentina and Brazil). We show the potential for elevating domestic income in exports by increasing manufacturing done within a country before export.JEL classification: F14, L61, L65, L66, L71, O13, Q17
DNA Hypermethylation of Brain-Derived Neurotrophic Factor is Associated with High Levels of Polybrominated Diphenyl Ethers in the Cord Serum: A Laizhou Wan Birth Cohort Study From China
Authors: Chen Limei , Zhang Yan , Zhou Yijun , Shi Rong , Tian Ying , Gao Yu 
Published: September 2021

Abstract
Background

Recent studies have suggested that in utero exposure to environmental organic pollutants, such polybrominated diphenyl ethers (PBDEs) and bisphenol A may induce epigenetic alterations, specifically by modifying the patterns of DNA methylation. We investigated the relationship between PBDE exposure and BDNF DNA methylation.
Methods

We measured the levels of eight PBDE congeners in umbilical cord serum samples using gas chromatography/mass spectrometry. Genomic DNA was extracted from whole cord blood samples. The methylation status of the BDNF gene was determined using methylation-specific PCR with primers specific for either methylated or unmethylated alleles. The unconditional logistic regression model was used to investigate the relationship between PBDE levels and BDNF DNA methylation.
Results

The total PBDE congener level (range) in cord serum samples was 23.17 (4.17–2459.46) ng/g lipid. After adjusting for potential confounders, the incidence of BDNF DNA methylation status may increase when cord serum BDE-28, BDE-47, BDE-99 and BDE-100 levels increased (OR = 3.32, 95% CI: 1.01, 10.85; OR = 7.89, 95% CI: 1.75, 35.66; OR = 7.34, 95% CI: 1.79, 30.09; OR = 3.96, 95% CI: 1.15, 13.68; respectively).
Conclusions

We found that the levels of BDE-28, -47, -99, and − 100 were positively associated with BDNF DNA hypermethylation. Changes in cord blood BDNF DNA methylation may be a part of the biological pathway underlying in utero PBDE exposure and adverse foetal growth.