bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of non-alcoholic fatty liver disease (NAFLD) severity with novel serum-based markers: A pilot study
Authors: Goyale Atul , Jain Anjly , Smith Colette , Papatheodoridi Margarita , Misas Marta Guerrero , Roccarina Davide , Prat Laura Iogna , Mikhailidis Dimitri P. , Nair Devaki , Tsochatzis Emmanuel 
Published: November 2021

Background/Aims
Non-alcoholic fatty liver disease (NAFLD) represents a significant public health issue. Identifying patients with simple steatosis from those with non-alcoholic steatohepatitis (NASH) is crucial since NASH is correlated with increased morbidity and mortality. Serum-based markers, including adipokines and cytokines, are important in the pathogenesis and progression of NAFLD. Here we assessed the usefulness of such markers in patients with NAFLD.

Methods
This prospective, cross-sectional study included 105 adult patients with varying severity of NAFLD. Twelve serum-based markers were measured by 3 biochip platforms and 2 enzyme-linked immunosorbent assay (ELISA) methods. We also developed a NAFLD individual fibrosis index (NIFI) using the serum-based markers mostly correlated with fibrosis severity.

Results
Sixty-one out of 105 patients were male (58.1%) with mean age was 53.5 years. Higher Interleukin-6 (IL-6) increased (p = 0.0321) and lower Matrix Metalloproteinase-9 (MMP-9) serum levels (p = 0.0031) were associated with higher fibrosis as measured by Fibroscan® in multivariable regression analysis. Using receiver-operating characteristic (ROC) curve analysis for the NIFI, area under the curve for predicting Fibroscan values ≥ 7.2 kPa was 0.77 (95%CI: 0.67, 0.88, p<0.001), with sensitivity of 89.3%, specificity of 57.9% and a positive likelihood ratio of 2.8.

Conclusions
Increasing fibrosis severity in NAFLD is associated with differential expression of IL-6 and MMP-9. NIFI could be valuable for the prediction of advanced NAFLD fibrosis and potentially help avoid unnecessary interventions such as liver biopsy in low-risk patients.
Combined Endoscopic Stent-In-Stent Placement by Lumen-Apposing Metal Stents Through Self-Expanding Metal Stents for Simultaneous Malignant Biliary and Duodenal Obstruction
Authors: Metelli Flavio , Pezzoli Alessandro , Fabbri Carlo , Pizzo Elena , Arena Rosario , Cifalà Viviana , Simone Loredana , Solimando Riccardo , Merighi Alberto 
Published: November 2021

ABSTRACT
The palliation of simultaneous biliary and duodenal obstruction in patients with advanced pancreatic cancer is a clinically and technically challenging scenario. Endoscopic procedures are a valid alternative to surgical or percutaneous transhepatic biliary drainage. The availability of self-expanding metal stents (SEMSs) and lumen-apposing metal stents (LAMS) have expanded therapeutic options. We describe a case in which biliary and duodenal obstructions were treated successfully with the combined use of SEMS and LAMS devices. Endoscopic ultrasound-guided biliary drainage with the use of new LAMS and a duodenal SEMS can be a valid option in expert hands as a palliative and minimally invasive treatment for gastric outlet and biliary obstruction.
THE FRENCH ASPECTS IN THE EDUCATION PATTERN OF THE POLISH NOBILITY IN THE SEVENTEENTH CENTURY
Authors: Serwański Maciej 
Published: November 2021

The pattern of education of the Polish noble youth in the seventeenth century changed in comparison with the preceding century. In the latter, the mul-tinational, multicultural and multidenominational nature of the Polish-Lithuanian Commonwealth nurtured attitudes of widely understood tolerance both in terms of ideology and in practice. Poland was receptive to strong Re-naissance influence, while numerous sons of the Polish nobles studied abroad, mainly in Italy but also in Germany and France. The education system in the Jagiellonian monarchy of reflected the trends and the ideals of contemporary European education. The seventeenth century saw increased influence of the Counter-Reformation in the Nobles’ Commonwealth.
The ideas of Sarmatism, embracing xenophobia, religiosity and self-glorification of the existing, petrified political system, became more pro-nounced. These tendencies were broadly present in the pattern of the educa-tion of nobility, a pattern that was prone to strong Jesuit influence in the spirit of the doctrine laid down by the Council of Trent.
Study on the Creep-Fatigue Interaction Behavior of 1Cr11Ni2W2MoV Steel
Authors: Liu Lanzhou , Gao Yifei , Niu Tong , Zhang Zhiwei , Wang Yanjiang , Chen Xin 
Published: November 2021

Abstract
In order to investigate the creep-fatigue interaction of 1Cr11Ni2W2MoV steel, strain-controlled low-cycle fatigue tests were performed at various strain ranges with fully reversible cycle of triangular waveform at 500°C. In addition, different hold times were introduced at the maximum tensile strain to investigate the impact of creep damage on fatigue life. Fracture surfaces and axial section were evaluated in terms of crack growth behavior and propagation path. The creep-fatigue life decreased with increasing hold time. It was observed that cyclic softening effect intensified with tensile holding. Crack initiation and growth behavior changed in relation to hold time that exceeded 60 s at a strain range of 1.2 %, which led to premature failure. Under the present test conditions, a good description of fatigue life was provided by the model based on inelastic strain energy density.
Organic Compounds Evaluation from Fumes Generated in Laboratory by Bio-recycled Asphalt Mixtures
Authors: Gaudefroy Vincent , Presti Davide Lo , Porot Laurent , Pouget Simon , Planche Jean-Pascal , Williams Chris , Chailleux Emmanuel 
Published: November 2021

Abstract
Using bio-binder and bio-additives as recycling agents for asphalt mixtures with high-content of reclaimed asphalt (RA) is proving to be feasible. It is still not clear whether this combination might provide new known hazardous emissions from airborne binder fumes. The health hazard related to airborne bitumen fume generation is primarily relevant for paving crews, whereas there is little opportunity for exposure for asphalt plant workers. In this study, measurements of gaseous organic compounds from airborne binder fumes of selected bio-asphalt mixtures have been measured during the laboratory mixing process by using a thermo-mixer equipped with a chimney at University Gustave Eiffel. Parameters studied are the binder nature, mix formula, and mixing temperatures. Results show that generally combining bio-based materials and RA is as safe as using conventional bitumen and RA; however, thanks to this approach, it was possible to identify a strong link between bituminous materials’ composition and their emission potential.
Vertical Random Vibration Test Spectrum to Simulate Forklift Handling Environment
Authors: Böröcz Péter , Horvath Laszlo , Huang Yu Yang 
Published: November 2021

Abstract
Analyzing and measuring the vibration environment during distribution is fundamental to understanding and simulating the ability of a packaged-product system to avoid any damages from transportation hazards. During distribution, various vehicles, including forklifts, are used to perform shipping and handling tasks such as loading, unloading, and warehouse organizing processes. The aim of this paper was to provide an understanding of the average vibration levels that occur during handling so they can be used in pre-shipment testing. Various forklifts were observed, measured, and analyzed to obtain information about their average vibration levels while performing recommended tests. The measured acceleration-time data were analyzed in terms of power spectral densities (PSD) and presented with statistical data that provided an understanding of the variability of intensity. The PSD peaks were between approximately 2.5 and 5 Hz, and then they decreased to 120 Hz. The number of instances over 120 Hz was extremely low. The final recommended vibration test spectrum was determined to be in the frequency range of 1–120 Hz and the data were smoothed between six breakpoints.
Serotonin 2C Antagonism in the Lateral Orbitofrontal Cortex Ameliorates Cue-Enhanced Risk Preference and Restores Sensitivity to Reinforcer Devaluation in Male Rats
Authors: Hathaway Brett A. , Schumacher Jackson D. , Hrelja Kelly M. , Winstanley Catharine A. 
Published: November 2021

AbstractPrevious research has indicated that reward-paired cues can enhance disadvantageous risky choice in both humans and rodents. Systemic administration of a serotonin 2C receptor antagonist can attenuate this cue-induced risk preference in rats. However, the neurocognitive mechanisms mediating this effect are currently unknown. We therefore assessed whether the serotonin 2C receptor antagonist RS 102221 is able to attenuate cue-enhanced risk preference via its actions in the lateral orbitofrontal cortex (lOFC) or prelimbic (PrL) area of the medial prefrontal cortex (mPFC). A total of 32 male Long–Evans rats were trained on the cued version of the rat gambling task (rGT), a rodent analog of the human Iowa gambling task, and bilateral guide cannulae were implanted into the lOFC or PrL. Intra-lOFC infusions of the 5-HT2Cantagonist RS 102221 reduced risky choice in animals that showed a preference for the risky options of the rGT at baseline. This effect was not observed in optimal decision-makers, nor those that received infusions targeting the PrL. Given prior data showing that 5-HT2Cantagonists also improve reversal learning through the same neural locus, we hypothesized that reward-concurrent cues may amplify risky decision-making through cognitive inflexibility. We therefore devalued the sugar pellet rewards used in the cued rGT (crGT) through satiation and observed that decision-making patterns did not shift unless animals also received intra-lOFC RS 102221. Collectively, these data suggest that the lOFC is one critical site through which reward-concurrent cues promote risky choice patterns that are insensitive to reinforcer devaluation, and that 5-HT2Cantagonism may optimize choice by facilitating exploration.
Stochastic Volatility Estimation of Stock Prices using the Ensemble Kalman Filter
Authors: Mahatma Yudi , Hadi Ibnu 
Published: November 2021

AbstractVolatility plays important role in options trading. In their seminal paper published in 1973, Black and Scholes assume that the stock price volatility, which is the underlying security volatility of a call option, is constant. But thereafter, researchers found that the return volatility was not constant but conditional to the information set available at the computation time. In this research, we improve a methodology to estimate volatility and interest rate using Ensemble Kalman Filter (EnKF). The price of call and put option used in the observation and the forecasting step of the EnKF algorithm computed using the solution of Black-Scholes PDE. The state-space used in this method is the augmented state space, which consists of static variables: volatility and interest rate, and dynamic variables: call and put option price. The numerical experiment shows that the EnKF algorithm is able to estimate accurately the estimated volatility and interest rates with an RMSE value of 0.0506.Keywords: stochastic volatility; call option; put option; Ensemble Kalman Filter. AbstrakVolatilitas adalah faktor penting dalam perdagangan suatu opsi. Dalam makalahnya yang dipublikasikan tahun 1973, Black dan Scholes mengasumsikan bahwa volatilitas harga saham, yang merupakan volatilitas sekuritas yang mendasari opsi beli, adalah konstan. Akan tetapi, para peneliti menemukan bahwa volatilitas pengembalian tidaklah konstan melainkan tergantung pada kumpulan informasi yang dapat digunakan pada saat perhitungan. Pada penelitian ini dikembangkan metodologi untuk mengestimasi volatilitas dan suku bunga menggunakan metode Ensembel Kalman Filter (EnKF). Harga opsi beli dan opsi jual yang digunakan pada observasi dan pada tahap prakiraan pada algoritma EnKF dihitung menggunakan solusi persamaan Black-Scholes. Ruang keadaan yang digunakan adalah ruang keadaan yang diperluas yang terdiri dari variabel statis yaitu volatilitas dan suku bunga, dan variabel dinamis yaitu harga opsi beli dan harga opsi jual. Eksperimen numerik menunjukkan bahwa algoritma ENKF dapat secara akurat mengestimasi volatiltas dan suku bunga dengan RMSE 0.0506.Kata kunci: volatilitas stokastik; opsi beli; opsi jual; Ensembel Kalman Filter.
Validade do questionário internacional de atividade física (IPAQ) em idosos: uma revisão integrativa da literatura
Authors: Miranda Kessketlen Alves , Da Silva Ivaldo Miranda , Cerqueira Juliana Cecilio , Santos Maria Paula Maia dos 
Published: November 2021

Introdução: O questionário Internacional de Atividade Física (IPAQ) tem sido amplamente utilizado nas pesquisas. É considerado uma boa ferramenta de medição de Atividade Física (AF), no entanto, este questionário não é específico para idosos, geralmente, é aplicado à população em geral. Objetivo: Realizar uma Revisão Integrativa da Literatura apresentando os estudos que investigaram a validade do IPAQ na avaliação de AF em idosos nos últimos seis anos. Métodos: Foi realizada uma Revisão Integrativa da Literatura nas bases de dados PUBMED, BVS e SCOPUS, relativa aos anos de 2014 a 2020, utilizando-se os descritores: Elderly, Aged, IPAQ questionnaire validity, Physical Activity e Exercise. Resultados: Foram selecionados oito artigos cuja metodologia apresenta a validade do IPAQ, na avaliação em idosos com idade ≥65 anos. Seis dos artigos selecionados apresentaram em suas metodologias a avaliação realizada pelo IPAQ-L (versão longa), e apenas dois artigos apresentaram IPAQ-S (versão curta). Conclusão: O IPAQ- L tem sido amplamente utilizado para avaliar os níveis de AF e comportamento sedentário (CS) em idosos. As evidências demonstram que a aplicação do questionário combinado com os dados do acelerômetro, tem mostrado medições satisfatórias, no entanto, futuras versões devem ser estruturadas para atender a este público específico.
To a problem of the markers of vessels wall at EPH-gestosis
Authors: Ailamasian E. K. , Zainulina M. S. , Petrishev N. N. 
Published: November 2021

Content in blood of markers of damage of a vessel wall (factor Willebrand, tissue of a catalyst plasminogen, cells circulating in blood endothelium), and also intravessel an aggregate platelet and uterine - placental bloodcurrent at 205 patients, among which woman with physiological current of pregnancy and with EPH-gestosis of a various degree of weight is investigated. The patients with nephropathy and preeclampsy were divided into groups depending on a method of treatment.
The 46 pregnant with EPH-gestosis of a various degree of weight was carried by clofelin in a daily doze 0,00015-0,0003 g during 7-10 days, 42 women therapy (the course doze 25,5-27 g of dry substance) is spent magnesium, 59 pregnant received clofelin and magnesium therapy in the above-stated dozes. The group of comparison formed 38 patients.
It was shown the important value of a research of markers of damage endothelium for diagnostics, definition of a degree of weight and control for efficiency of therapy pregnant with EPH-gestosis. Clofelin and magnesium, used for treatment of pregnant with EPH-gestosis as is independent, and in a combination, have endotheliumprotection operation, as reduce in authentic decrease of a content in blood of a marker of vessel's disorders of circulating cells endothelium, and also reduce intravessel an aggregate of platelets and improve uterine-placental bloodcurrent.
Positive experience of replacement hormonal therapy in patients with climacteric syndrome with Proginova, Cyclo-Proginova and Climen
Authors: Vishnevsky A. S. , Safronnikova N. R. , Melnikova N. U. , VIadykina T. N. , Artamonova E. A. 
Published: November 2021

At 75 patients (average age 57,2 years, average postmenopausal period 3,5 years) the hormonal replacement therapy is carried out because of climacteric syndrome with Proginova (29 women), Cyclo-Proginova (25 women) and Climen (21 women). The preparations were nominated in a cyclic mode (average duration of treatment has made 5,6 cycles).
There is marked a high therapeutic effect as reduction of frequency of vegetovascular climacteric frustrations in Proginova application (83 % ), Cyclo- Proginova (84 %) and Climen (96%).
The application of Proginova, Cyclo-Proginova and Climen resulted in normalization of lipid spectrum of blood by 3 month of treatment, that was expressed in authentic decrease in initially raised cholesterin and cholesterin of low density, with increase of the contents of cholesterin fraction of high density.
The marked normalization of lipid spectrum as a result of hormonal replacement therapy can be considered as pathogenic influence directed on normalization in age - associated metabolic infringements in female organism.
Hematological changes in hypothyroidism and hyperthyroidism in adults
Authors: Chauhan Seema G , Kadgi Nalini V , Nakate Leena A 
Published: November 2021

Thyroid function disorders are among the most common endocrine diseases. Thyroid disorders can cause certain forms of anemia, more commonly in hypothyroidism. Slightly decreased TLC, relative neutropenia, relative lymphocytosis or relative eosinophilia may be found in thyroid disorders. These observations confirmed the association between thyroid gland dysfunction and hemopoiesis.1) To study the pattern of hematological changes in thyroid dysfunction 2) To correlate thyroid function tests with complete blood count & red cell indices findings 3) To correlate complete blood count investigations and peripheral blood smear findings with serum TSH levels.It was an Observational study conducted during 18 months of period from March 2018 to October 2019 with 100 subjects of hypothyroidism, 80 subjects of hyperthyroidism and 100 euthyroid subjects as control group. CBC was done on automated cell counter. PBS was stained with Leishman stain and observed under microscope. TFTwas done by immunoassay method.It was done with SPSS Software.: Predominance of female was seen in hypothyroidism and hyperthyroidism. Significant decrease was seen in RBC, Hb, HCT, MCV and MCH in hypothyroid group, while in hyperthyroid group RBC, Hb and HCT were significantly decreased as compared with euthyroid control group. Both groups showed significant increase in RDW as compared with control group.It is important to carefully evaluate the thyroid hormones in cases of unexplained anemias. So, periodic evaluation for probable hematological changes should be done in all the patients with hypothyroidism and hyperthyroidism.
Seroepidemiological Study of Hepatitis A in Medical Students of Mazandaran University of Medical Sciences in 2019
Authors: Shirazinia Saman , Shayan Navid Reza , Ghiyasi Moghaddam Negin , Ameli Nima , Alian Shahriar , Davoodi Lotfollah 
Published: November 2021

Introduction: Hepatitis A (HA) is a common infectious disease caused by the HA virus that primarily affects the liver. We need to determine the safety status and infection rate in the community. Therefore, we decided to study the Seroepidemiological of HA in medical students of Mazandaran University of Medical Sciences in 2019.Material and Methods: This was a cross-sectional descriptive-analytical study prospectively examining anti-HAV antibodies in medical students of Mazandaran University of Medical Sciences in 2019. Patient demographic data, laboratory results of anti-HAV IgG and vaccination history were recorded. Four cc of blood were drawn from each student for the anti-HAV IgG test and after the test was performed. Data were analyzed using SPSS 24 software.Results: One hundred and fifty-five students were interviewed. The mean age (standard deviation) of the students in this study was 23.81 (1.47) years. Ninety-nine (63.9%) of the students were male. Therefore, it was caused by previous infection with HAV and 120 (77.4%) cases were considered susceptible individuals whose serum anti-HAV IgG was negative. This was not seen to be statistically significant (P=0.754). According to the test, 77.4% of the predictions were correct. None of the variables of sex, age, history of underlying disease, place of residence, and history of travel had a significant effect on the incidence and positivity of anti-HAV IgG.Conclusion: This study showed that the incidence of anti-HAV IgG was positive in 22.6% of the students, which is much lower than previous studies. This may be due to the higher level of health in this segment of the population.
MICROBIOLOGICAL AND SANITARY - CHEMICAL CHARACTERISTICS OF WASTEWATER FROM PHARMACEUTICAL COMPANY
Authors: Gudzenko T. V. , Gorshkova O. G. , Voliuvach O. V. , Burlaka T. V. , Metelitsina I. P. 
Published: November 2021

Aim. Оssessment of wastewater from a pharmaceutical company according to sanitary-microbiological and chemical indicators to determine the method of treatment and remediation of them from pollutants and pathogens. Methods. In sanitary and bacteriological studies, classical microbiological methods were used to determine the total microbial number of pathogenic bacteria. Determination of the concentration of ammonium, nitrite and nitrate in wastewater samples from a pharmaceutical company was carried out spectrophotometrically using the chemical reaction of ions to Nessler's reagent, Griss reagent, and phenol sulfide acid. The content of heavy metal ions was determined by the method of electrothermal AAS using the device "Saturn-2", by the photometric method using 4-aminoantipyrine – phenol, by the extraction-photometric method – by surfactants, by the method of infrared spectrometry – by petroleum hydrocarbons. Results. It was experimentally confirmed that the total microbial count in wastewater samples from a pharmaceutical company slightly exceeded the standard value. The BGKP index and the E. coli index were within the normal range. The pathogenic bacteria Salmonella moscow and Klebsiella pneumoniae were found in the wastewater of pharmaceutical company. The contamination of pharmaceutical stock can be judged by the 8.5 times excess of the concentration of ammonium ions in them compared to the MPC. The results of chemical analysis of wastewater samples from a pharmaceutical company indicate their multicomponent composition.Of the heavy metal ions, ions of zinc, copper, lead, hexavalent chromium and cadmium were mainly detected. With the exception of cadmium ions, the concentration of heavy metal ions was 1.4–7.2 times higher than the MPC norm. Anionic surfactants predominated in pharmaceutical stocks – their concentration was 8.2 ± 0.7 mg/dm3. The level of phenolic and oil pollution of wastewater was minimal in comparison with the content of anionic surfactants, which could be caused by the activity of aboriginal strains of bacteria-destructors with a high phenolic capacity. Conclusion. The results of sanitary-microbiological and chemical analysis of wastewaters of a pharmaceutical company indicate their multicomponent nature and environmental hazard – they contain pathogenic bacteria Salmonella moscow and Klebsiella pneumoniae and pollutants of various nature: heavy metal ions Cu (II), Cr (VI) and Pb (II) at a concentration of 36.0 ± 14 μg/dm3, 3.0 ± 0.4 μg/dm3 and 14.0 ± 0.7 μg/dm3, respectively, and organic pollutants – phenol, oil products and anionic surfactants at a concentration of 0.003 ± 0.0006 mg/dm3, 0.81 ± 0.05 mg/dm3 and 8.2 ± 0.7 mg/dm3, respectively. Werecommend to carry out a comprehensive purification of wastewater from a pharmaceutical company from phenol, heavy metal ions [Cu (II), Cr (VI), Zn (II)], oil products, anionic surfactants and pathogens.