bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose tissue: colors, depots and functions
Authors: Romantsova T. I. 
Published: October 2021

Obesity is a chronic disease characterized by excessive accumulation of adipose tissue. The prevalence of obesity and associated diseases has prompted researchers to expand the study of the biology of adipose tissue. New technologies have significantly expanded the understanding of adipogenesis mechanisms, various aspects of lipid and glucose metabolism, as well as the paracrine and endocrine functions of adipose tissue. Adipose tissue is a complex, heterogeneous endocrine organ. The existence of several shades of adipocytes demonstrates their morphological and functional heterogeneity. The main function of white adipose tissue is to store energy. Brown and white adipocytes perform a predominantly thermogenic function. Bone marrow (yellow) adipose tissue regulates the processes of bone remodeling and hematopoiesis. Pink adipocytes are formed during pregnancy and satisfy the energy needs of the offspring. The study of the biology of adipose tissue is crucial to understanding the pathophysiology of obesity and determining its molecular relationships with type 2 diabetes as well as cardiovascular and oncological diseases. The review presents current literature data on the origin, adipogenesis, and functional properties of adipose tissue depending on its cellular composition and localization. It outlines the nature of changes in adipose tissue in obesity and the clinical significance and therapeutic potential of various adipose tissue depots.
Potential prognostic value of miRNAs as biomarker for progression and recurrence after nephrectomy in renal cell carcinoma: a literature review
Authors: Fasanella Daniela , Antonaci Alessio , Esperto Francesco , Scarpa Roberto M. , Ferro Matteo , Schips Luigi , Marchioni Michele 
Published: October 2021

Abstract

Objectives
We provide a systematic literature review on tissue miRNAs in patients with RCC to evaluate and summarize their usefulness as prognostic markers. We undertook a systematic search for articles in English using the PubMed-Medline database from January 2010 to December 2020. Studies were identified and selected according to the PRISMA criteria and the PICO methodology. The population consisted of RCC patients undergoing nephrectomy and the main outcome of interest was recurrence-free survival (RFS). Only studies providing hazard ratios (HRs) from multivariate or univariate analyzes with corresponding 95% confidence intervals (CI) and/or area under the curve (AUC) were considered.

Content
All nine included studies (1,541 patients) analyzed the relationship between tissue miRNA expression levels (up or downregulated) and RFS. Some of these found that the methylation status of miR-9-1, miR-9-3 and miR-124 was associated with a high risk of relapse. Moreover, miR-200b overexpression was associated with OS. MiR-210 overexpression indicated a shorter OS than those who were miR-210 negative. Finally, patients with high miR-125b expression had shorter cancer-specific survival (CSS) than those with low expression; similarly, patients with low miR-126 expression also had shorter CSS time.

Summary and outlook
Several studies tested the usefulness of specific miRNAs to predict RCC recurrence. Some of them showed a fair accuracy and strong relationship between specific miRNA over or under-expression and survival outcomes. However, results from these studies are preliminary and miRNAs use in routine clinical practice is still far to come.
Lebanese conversational style and cultural values
Authors: Louis Sasha G. , Khoudary Rana N. 
Published: October 2021

AbstractThis paper investigates the Lebanese conversational style in relation to Lebanese cultural values. The study adopts a discourse analysis approach based on interactional sociolinguistic methodology for the analysis of audio-recordings and semi-structured interviews involving Lebanese nationals (multi-active culture) and members of linear-active cultures, in addition to participant observation. Four distinctive linguistic features characterizing the Lebanese conversational style are identified: topic (focus on personal topics and abrupt topic shift), pacing (overlap and fast pace), expressive phonology and intonation, and formulaic language. The findings of this study reveal that the Lebanese have a high-involvement conversational style as a result of their cultural values which reflect those of high-context, multi-active and collectivist cultures. Furthermore, a connection is made between cultural and communicative differences which can account for instances of stereotyping and misunderstandings between members of the two cultural groups.
The frame system as an interlingual representation for parallel texts
Authors: Pluwak Agnieszka 
Published: October 2021

AbstractOne of the key problems in comparative studies based on frame semantics is the question whether frames can become an interlingua. This paper argues that not only single frames, but theirsystemsorframe semantic domain representationsconsisting of frames and their relations are also useful in comparative studies. Such a system of frames helps one explain why seemingly unrelated expressions in different languages find a common denominator in higher-order frames, thus becoming semantic-pragmatic equivalents. To support this argument, an analysis of Polish, English and German lease agreements as parallel texts is conducted and the benefits of this approach to comparative studies are presented. The study is in line with the recent FrameNet initiatives, such as the Global FrameNet and automatic translation studies. However, it differs in some methodological aspects. Instead of using FrameNet as the given lexical resource, domain specific frames are defined starting from common general concepts of the analyzed semantic domain. A text-based approach rather than a comparison of bi-sentences or phrases is adapted. The work thus introduces a new approach to comparative studies based on frame semantics and frame semantic research. It also follows the recent research trend of adding a pragmatic dimension to frame semantic analysis by analyzing frames in context.
Gene editing therapy ready for cardiovascular diseases: opportunities, challenges, and perspectives
Authors: Zhou Jun , Ren Zhuoying , Xu Jie , Zhang Jifeng , Chen Y. Eugene 
Published: October 2021

Abstract
Gene editing nucleases (GENs), represented by CRISPR/Cas9, have become major tools in biomedical research and offer potential cures for many human diseases. Gene editing therapy (GETx) studies in animal models targeting genes such as proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein C3 (APOC3), angiopoietin Like 3 (ANGPTL3) and inducible degrader of the low-density lipoprotein receptor (IDOL) have demonstrated the benefits and advantages of GETx in managing atherosclerosis. Here we present our views on this brand new therapeutic option for cardiovascular diseases (CVD).
The preparations of nanoporous carbon with multi-heteroatoms co-doping from black liquor powders for supercapacitors
Authors: Hao Pengfei , Yi Yanjie , Li Youming , Hou Yi 
Published: October 2021

Abstract
A green and economically viable route without any additional activation agents and templates has been developed to synthesize biomass-derived nanoporous carbon for superior electric double-layer capacitors via direct pyrolysis of dried black liquor powders, which is the main waste in pulping and paper-making industry. The resulting carbon materials present hierarchical porosity and moderate specific surface area of 1134

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, as well as multi-heteroatoms co-doping such as N, S, Na and K, which exist originally in black liquor. When evaluated as electrode materials for supercapacitors in 6 M KOH aqueous electrolyte, the-prepared carbon samples deliver a significantly high gravimetric capacitance of 331

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in a three-electrode system. Moreover, the fabricated symmetric supercapacitor also possesses a gravimetric capacitance of 211

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, with an impressive long-term cycling stability of 92 % capacitance retention after 3000 cycles. This work explores a suitable and scalable approach for mass production of high-performance electrode materials with industrial wastes on the base of cost-efficiency and environment-friendship.
Interpretation of force profiles in mill-scale LC refining
Authors: Aigner Matthias , Olson James , Sun Yu , Wild Peter 
Published: October 2021

AbstractA set of piezo electric force sensors is implemented in a 52-inch mill-scale low consistency refiner to explore the effect of varying operating conditions on bar force profiles. The sensor replaces a short length of a stator bar and measures normal and shear forces applied during the passage of each rotor bar. In previous work with this type of force sensor a rotary encoder was used to investigate force profiles for individualbar passing events(BPE) on a 16-inch laboratory-scale refiner. In the work presented here, force profiles for individual BPEs are identified based on key features in the time domain force data. The individual bar force profiles are classified assingle peakevents which feature one peak corresponding to thefiber compression forceand asdual peakevents corresponding to fiber compression force and thecorner force. The bar passing events are then analysed based on theirmean force profilesand theirdual peak ratioin the bar passing event. Findings are compared and validated by previous work on bar force profiles. It is shown that dual peak events which are considered to represent the corner force, are present through out the whole range of refining and increase with increased refining energy. This increases the understanding of the way corner force contributes to the refining process. Furthermore, it is found that different radial positions on the stator plate are subjected to different force profiles. This is thought to be due to the difference in tangential speed and a change in the fiber and floc material properties at different radial positions.
Job as a Steadfast Wrestler: Athletic Exemplarity in John Chrysostom and Severian of Gabala
Authors: De Backer Olympe , Valgaeren Thomas 
Published: October 2021

Abstract
In Greek Late Antiquity, the Biblical character of Job was portrayed in two different ways: as Job the impatient complainer and as Job the patient sufferer. The latter image has often been enriched by means of agonistic metaphors describing Job as the perfect athlete wrestling with the devil. Despite its pervasiveness, however, this image has only been studied in a sporadic and incomplete way. The article intends to bridge this gap by researching how Christian authors strategically used the image of Job as an athlete in order to increase his impact as a role model. First, it briefly explores this image in Biblical traditions and in the works of Origen, Basil of Caesarea, and Gregory of Nyssa. The main part of the article then focuses on the works of John Chrysostom and Severian of Gabala. It is necessary to ascertain which image(s) of Job each author presents and how this image is presented as well as to lay bare the function and relevance of the agonistic metaphors that are used to portray Job. To achieve this aim, the article offers a philological analysis of some crucial primary sources in their socio-cultural context. The agonistic metaphors have also been analysed according to the principles of cognitive-linguistic metaphor theory. In the end, the article shows how Chrysostom and Severian used Job as a model-athlete to incite their audience to strive for a perfect Christian life. It demonstrates that the agonistic metaphors are deeply significant for the portrayal of Job, since they incite the audience to view Job’s life, and consequently also their own life, from a new angle. By turning Job the passive sufferer into an active athlete who is the ultimate example of resilience, the metaphors shed a new light on Job’s suffering and thereby on the problem of theodicy.
The Biblical Text and its Variants at the Heart of the Debate between the Emperor Julian and Cyril of Alexandria: The Cases of Genesis 6,2 and 49,10
Authors: Boulnois Marie-Odile 
Published: October 2021

Abstract
The biblical argument plays a considerable role in Julian’s controversy against Christianity and has certainly contributed to the “invincible efficiency” of his work, as pointed out by his adversary Cyril of Alexandria. This paper focuses on two verses Gen 49:10 and Gen 6:2 invoked by Julian to prove that Moses has never spoken, either of the coming of Jesus, or of an Only-Begotten Son of God, and consequently that Christians are unfaithful to Moses. The specificity of this debate is that it concerns not only the interpretation of these verses, but the very form of the biblical text, its possible falsification or the existence of marginalia. In this second case, Cyril’s refutation in his Contra Julianum, as well as parallels in other Cyrillian works, helps to understand that Julian is referring to a biblical paratext, a rare element that enhances his reputation as a good connoisseur of the exegetical debates of his time, and provides a particularly interesting testimony about the material transmission of the biblical text.
Einführung neuer Produktvarianten in digitalen Montage-Assistenzsystemen
Authors: Bayer Christian , Scholz Patrick , Metternich Joachim 
Published: October 2021

Abstract
Assistenzsysteme bieten die Möglichkeit, Werker bei manuellen Montageprozessen mit zahlreichen Varianten und Arbeitsinhalten zu unterstützen. Die Konfiguration eines bestehenden Assistenzsystems für neue Produktvarianten kann einen hohen Aufwand in der Arbeitsvorbereitung verursachen. Eine Darstellung des Status quo beim Anlegen neuer Produktvarianten fehlt allerdings bisher aufgrund der Neuartigkeit der Systeme. Daher werden der Konfigurationsprozess und die Herausforderungen anhand einer Literaturrecherche und durch Interviews strukturiert aufgearbeitet.
DINAMIKA PENERAPAN PRINSIP-PRINSIP PEKERJAAN SOSIAL DALAM UPAYA MENANGGULANGI GELANDANGAN DAN PENGEMIS
Authors: Humairoh Siti 
Published: October 2021

Abstract. This study describes the practice of social work in an effort to further improve the quality and quantity as a helping profession for others, by applying the principles of social work in accordance with the code of ethics contained in it. This research is a type of qualitative-descriptive research, data collection techniques with observation, interviews, documentation. This research is oriented to the description of the application of social work principles and the dynamics of efforts to tackle homeless people and beggars in Kab. Jember and how to work with team work. The performance of this research explains the existence of several social work principles applied by Liposos Jember: individualization, meaningful relationships, acceptance, communication and expression of feelings, controlled emotional involvement, non-judgmental attitude, self-determination, self-awareness, social learning, confidentiality. The dynamics are: the skills/skills of social workers themselves, determining the fate of the clients themselves, improper planning in the static innovation and innovation process, financial problems/budget funds, and there are several strategies carried out by social workers in dealing with dynamics in the application of social work principles as is the case when burn out, namely: Relax or accept reality, dedicated me time, self-relaxation, exercise and adequate rest. The results of this study also show that Liposos social workers work together in providing services to clients. Abstrak. Studi ini mendeskripsikan praktik pekerjaan sosial dalam upaya lebih meningkatkan kualitas dan kuantitas sebagai profesi penolong bagi sesama, dengan menerapkan prinsip pekerjaan sosial yang sesuai dengan kode etik yang terkandung di dalamnya. Penelitian ini merupakan jenis penelitian kualitatif-deskriptif, teknik pengumpulan data dengan observation, interview, documentation. Penelitian ini berorientasi tentang deskripsi penerapan prinsip pekerjaan sosial dan dinamikanya upaya menanggulangi gelandangan dan pengemis di Kab. Jember serta bagaimana bekerja dengan team work. Performa penelitian ini menjelaskan adanya beberapa prinsip pekerjaan sosial diterapkan oleh Liposos Jember: individualisasi, hubungan yang bermakna, penerimaan, komunikasi dan ekspresi perasaan, keterlibatan emosional terkontrol, sikap tidak menghakimi, penentuan nasib sendiri, kesadaran diri, pembelajaran sosial, kerahasiaan. Adapun dinamikanya yaitu: keterampilan/skill Peksos itu sendiri, menentukan nasib klien itu sendiri, perencanaan yang kurang tepat dalam proses inovasi dan inovasi yang statis, masalah keuangan/anggaran dana, serta terdapat beberapa strategi yang dilakukan oleh para peksos dalam menghadapi dinamika dalam penerapan prinsip pekerjaan sosial seperti halnya ketika burn out, yaitu: legawa atau menerima kenyataan, dedicated me time, self-relaksasi, latihan dan istirahat yang cukup. Hasil penelitian ini juga menunjukkan bahwa Peksos Liposos saling bekerja sama dalam memberikan pelayanan kepada klien. Kata kunci: .
Arroz, feijão e ultraprocessados: caracterização das refeições segundo o grau de processamento dos alimentos no Brasil
Authors: Xavier Rossetti Francini , Winnie Lo Wai Yee , Vieira da Silva Marina 
Published: October 2021

O objetivo foi descrever as refeições consumidas segundo o grau de processamento de alimentos e bebidas e analisar as evidências sobre o processo de substituição de preparações culinárias por alimentos ultraprocessados.Foram utilizados dados do consumo alimentar de 34.008 indivíduos da Pesquisa de Orçamentos Familiares de 2008-2009 por meio de registro alimentar. Refeições foram definidas a partir de horário de consumo e combinação dos alimentos e bebidas conforme a classificação NOVA e categorizadas em: tradicionais (preparações culinárias e/ou processados), mistas (preparações culinárias e/ou processados e ultraprocessados) e ultraprocessadas (exclusivamente ultraprocessados). Frequência de consumo dessas categorizações foram avaliadas por regressão linear univariada. Foram consumidas 4,52 [IC: 4,48-4,55] refeições, sendo 2,63 [IC: 2,59-2,67] tradicionais, 1,32 [IC: 1,30-1,35] mistas e 0,56 [IC:0,54-0,58] ultraprocessadas. A frequência de refeições mistas e ultraprocessadas foi maior entre mulheres, conforme aumento da renda, escolaridade, idade, residir no sul e sudeste e situação de domicílio urbana (p<0,05). Alimentos ultraprocessados são mais consumidos acompanhados de preparações culinárias, nas refeições mistas.
Создание образцового социалистического города Иваново-Вознесенск 1920–1930-х годов
Authors: Тимофеев Михаил Юрьевич 
Published: October 2021

В статье исследуется попытка превращения города Иваново-Вознесенска (с 1932 года — Иваново) в образцовый социалистический город, предпринятая в 1920–1930-е годы. Предпосылкой этой идеи была особая роль города в период Первой русской революции, когда во время всеобщей стачки в нем был создан Совет рабочих депутатов. Местные власти стремились опробовать в городе самые современные веяния в формировании городской среды и реализовать амбициозные архитектурные проекты. Поскольку социальнокультурную сферу пришлось создавать практически с нуля, в городе было возведено большое количество объектов в новых архитектурных формах конструктивизма, постконструктивизма и «пролетарской классики».
В 1918 году городская инфраструктура Иваново-Вознесенска была совершенно не приспособлена для выполнения функций губернского центра. Первоначально были реализованы планы по созданию водопровода и канализации, мощению улиц. Часть масштабных проектов — в частности, народный дом имени В. И. Ленина — не удалось реализовать из-за нехватки ресурсов. В результате массовых переименований 1927 года около 300 улиц получили в значительной степени идеологически маркированные названия. Символическими актами стало создание в 1918 году Политехнического института и пуск трамвая в 1934 году, а также открытие в 1925 году первой в СССР фабрики-кухни. В конце 1920-х годов в городе были построены две новые прядильные фабрики и огромный меланжевый комбинат.
С середины 1920-х до второй половины 1930-х годов в городе были построены несколько рабочих поселков, большое количество жилых домов, большой железнодорожный вокзал, банки, больницы, детские сады, большой кинотеатр, цирк, интернациональный детский дом, студенческие общежития. Такие проекты, как строительство Большого драматического театра и комплекса зданий для Политехнического института, предваряли всесоюзные конкурсы. На рубеже 1920–1930-х годов особое значение придавалось строительству дома-коммуны. Однако лишение города статуса родины первого Совета в 1936 году и ликвидация Ивановской промышленной области привели к тому, что значительная часть градостроительных планов не была реализована.
Medico-ecological aspects of physical and sexual development of the adolescent girls
Authors: Baranov A. N. , Lebedeva Т. В. 
Published: October 2021

It has been established that ecologic factors could badly influence on the development of the reproductive system. Among anthropogenic ecologic factors, metal pollutants are of special interest.
In our survey, we have revealed that adolescent girls, living in the territories polluted by the salts of heavy metals, tend to have intersexual type of body build, which has manifested in enlarged shoulder width, enlarged length of the arms and decreased transverse pelvic distances. The development of the secondary sexual signs was accompanied by the retardation in development of mammas, arm-pits pilosis and onset of the first menstrual period. The fact that adolescent girls live in the areas with elevated soil concentration of the salts of heavy metals should be considered as unfavorable, with feasible influence on the physical and sexual development.
DYNAMICS OF UKRAINIAN-AMERICAN RELATIONS DURING OBAMA'S ADMINISTRATION (2014-2016)
Authors: Pashkov V. O. 
Published: October 2021

The article analyzes the dynamics, interests of the parties, priority areas of cooperation and contradictions of Ukrainian-American relations in the post-Maid period, reveals the reasons for supporting Ukraine in resisting Russian aggression from the United States. The influence of the Revolution of Dignity on the geopolitical interests of the United States in Eastern Europe and the post-Soviet space is determined. It was determined that in 2014-2016. bilateral relations between Ukraine and the United States in terms of summit meetings and diplomatic support have reached their highest development in the 30th anniversary of Ukraine's independence. At the same time, they lacked practical content - specific projects and common interests.
The American strategy for Ukraine provided for limited military assistance and diplomatic containment of the Russian Federation in order to maintain the balance of power in the region.
Six areas were identified that formed the bilateral agenda - military-technical cooperation, political dialogue, support for reforms, the fight against corruption, energy, support for democratic institutions. The main directions of cooperation, projects and problems within each of these areas are disclosed in detail. In the context of the formation of "strategic friendship" after 2014, the parties demonstrated different diplomatic rhetoric. Ukrainian politicians emphasized the importance of strategic partnership between countries, military assistance, and American representatives put the need for economic reforms and the fight against corruption in the first place, pushing Ukrainian leaders to take appropriate action.
It was concluded that US-Ukrainian relations at this stage were more reminiscent not of a strategic partnership, but of patronage, where Kiev, as a clientele, sought protection from Russian aggression, and the United States saw the support of the pro-Western regime in Kiev as an opportunity to strengthen its positions in Eastern Europe and the post-Soviet space.