bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for Ovarian Endometriosis
Authors: Murakami Mayuko , Osuka Satoko , Muraoka Ayako , Hayashi Shotaro , Bayasula Bayasula , Kasahara Yukiyo , Sonehara Reina , Hariyama Yumi , Shinjo Kanako , Tanaka Hideaki , Miyake Natsuki , Yoshita Sayako , Nakanishi Natsuki , Nakamura Tomoko , Goto Maki , Hiroaki Kajiyama 
Published: November 2021

Abstract
Background

Endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects 10% of women of reproductive age. Ovarian endometriosis (OE) is the most common lesion in endometriosis and may cause infertility in addition to dysmenorrhea. Hormonal treatments for endometriosis suppress ovulation; hence, they are not compatible with fertility. The inflammasome is a complex that includes Nod-like receptor (NLR) family proteins that sense pathogen-/danger‐associated molecular patterns and homeostasis-altering molecular processes. It has been reported that the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing (NLRP) 3 inflammasome, which contributes to the activation of interleukin-1 beta (IL-1β), might be related to the progression of endometriosis. Therefore, the aim of the present study was to evaluate non-hormonal therapies for OE, such as the inhibitors of the NLRP3 inflammasome.
Methods

The expression of NLRP3 was measured in the eutopic endometrium (EM) of patients with/without endometriosis and OE and stromal cells derived from the endometrium of patients with endometriosis and OE (endometrial stromal cells [ESCs] and cyst-derived stromal cells [CSCs]). The effect of an NLRP3 inhibitor (MCC950) on ESC and CSC survival and IL-1β production was evaluated. We then administered MCC950 to a murine model of OE to evaluate its effects on OE lesions and ovarian function.
Results

NLRP3 gene and protein expression levels were higher in OE and CSCs than in EM and ESCs, respectively. MCC950 treatment significantly reduced the survival of CSCs but not that of ESCs. Moreover, MCC950 treatment reduced the co-localization of NLRP3 and IL-1β in CSCs and IL-1β concentrations in CSC supernatants. In the murine model, MCC950 treatment reduced OE lesion size compared to phosphate-buffered saline treatment (89 ± 15 vs. 49 ± 9.3 mm3 per ovary; P < 0.05). In addition, IL-1β and Ki67 levels in the OE-associated epithelia and oxidative stress markers of granulosa cells were reduced in the MCC950-treated group.
Conclusions

These results indicate that NLRP3/IL-1β is involved in the pathogenesis of endometriosis and that NLRP3 inhibitors may be useful for suppressing OE and improving the function of ovaries with endometriosis.
Factors Associated With Long-Term Survival in Gemcitabine-Concurrent Proton Radiotherapy For Non-Metastatic Locally Advanced Pancreatic Cancer: a Single-Center Retrospective Study
Authors: Ogura Yuta , Terashima Kazuki , Nanno Yoshihide , Park SungChul , Suga Masaki , Takahashi Daiki , Matsuo Yoshiro , Sulaiman Nor Shazrina , Tokumaru Sunao , Okimoto Tomoaki , Toyama Hirochika , Fukumoto Takumi 
Published: November 2021

Abstract
Background: Factors associated with long-term survival in gemcitabine-concurrent proton radiotherapy (GPT) for non-metastatic locally advanced pancreatic cancer (LAPC) remain unclear. This study aimed to determine the factors associated with long-term survival in GPT for non-metastatic LAPC.Methods: The medical records of 123 patients with LAPC treated with GPT between February 2009 and December 2019 at Hyogo Ion Beam Medical Center were retrospectively reviewed to assess the factors associated with long-term survival outcomes.Results: The median survival time of the total cohort treated with GPT was 18.7 months. The 1- and 2-year overall, local progression-free, and progression-free survival rates were 70.4% and 35.7%, 78.2% and 59.0%, and 38.6% and 20.8%, respectively. Multivariate analysis revealed that LAPCs at the pancreatic body-tail and those without anterior peripancreatic invasion were independently associated with longer overall survival (P = 0.040 and P = 0.015, respectively). The median survival times of patients with LAPC at the pancreatic body-tail and those with LAPC without anterior peripancreatic invasion were 24.1 and 28.1 months, respectively. LAPCs at the pancreatic body-tail had a higher volume ratio irradiated over 60 Gy equivalents at gross tumor volume than those at the pancreatic head (P < 0.001). LAPCs with anterior peripancreatic invasion had more peritoneal recurrence within 6 months than those without anterior peripancreatic invasion (P = 0.039).Conclusions: GPT is a promising treatment option for patients with LAPC at the pancreatic body-tail and those with LAPC without anterior peripancreatic invasion.
Forest malaria and prospects for antimalarial chemoprophylaxis among forest goers: findings from a qualitative study in Thailand
Authors: Jongdeepaisal Monnaphat , Khonputsa Panarasri , Prasert Orathai , Maneenet Suphitsara , Pongsoipetch Kulchada , Jatapai Anchalee , Rojanaprasert Chawarat , Sudathip Prayuth , Maude Richard James , Pell Christopher 
Published: November 2021

Abstract
Background Across the Greater Mekong Sub-region, malaria remains a dangerous infectious disease, particularly for people who visit forested areas where residual transmission continues. Because vector control measures offer incomplete protection to forest goers, chemoprophylaxis has been suggested as a potential supplementary measure for malaria prevention and control. To implement prophylaxis effectively, additional information is needed to understand forest goers’ activities and their willingness to use malaria prevention measures, including prophylaxis, and how it could be delivered in communities. Drawing on in-depth interviews with forest goers and stakeholders, this article examines the potential acceptability and implementation challenges of malaria prophylaxis for forest goers in northeast Thailand. Methods In-depth interviews were conducted with forest goers (n = 11) and stakeholders (n = 16) including healthcare workers, community leaders, and policymakers. Interviews were audio-recorded, transcribed and coded using NVivo, employing inductive and deductive approaches, for thematic analysis.Results Forest goers were well aware of their (elevated) malaria risk and reported seeking care for malaria from local health care providers. Forest goers and community members have a close relationship with the forest but are not a homogenous group: their place and time-at-risk varied according to their activities and length of stay in the forest. Among stakeholders, the choice and cost of antimalarial prophylactic regimen - its efficacy, length and complexity, number of tablets, potential side effects, and long-term impact on users - were key considerations for its feasibility. They also expressed concern about adherence to the preventive therapy and potential difficulty treating malaria patients with the same regimen. Prophylaxis was considered a low priority in areas with perceived accessible health system and approaching malaria elimination.Conclusions In the context of multi-drug resistance, there are several considerations for implementing malaria prophylaxis: the need to target forest goers who are at-risk with a clear period of exposure, to ensure continued use of vector control measures and adherence to prophylactic antimalarials, and to adopt an evidence-based approach to determine an appropriate regimen. Beyond addressing current intervention challenges and managing malaria incidence in low-transmission setting, it is crucial to keep malaria services available and accessible at the village level and provide support, especially in areas home to highly mobile populations.
Influence of Different Fixed System in Osteoporotic Lumbar Vertebrae in Fusion：A 3D Finite Element Analysis
Authors: Ye Han , Jincheng Wu , Xiaodong Wang , Wenshan Gao , Shaosong Sun , zepei Zhang , Kepeng Li , Jun Miao 
Published: November 2021

Abstract
Background：Posterior lumbar interbody fusion(PLIF) is the most common surgical method for lumbar fusion surgery, and pedicle screws（PS）can provide effective fixation strength in normal bone. However, pedicle screws are prone to loosening in osteoporotic patients. cortical bone trajectory (CBT) screw fixation and cement augmentation pedicle screw（CAPS） fixation are often used to reduce the risk of loosening. Although several studies are reported that the pullout strength of CBT screws or CAPS screws are higher than PS，There are no relevant studies on different internal fixation stress analysis. The purpose of this study was to compare the stresses of different fixation methods and analyze the stresses of different internal fixation systems through finite element analysis.Methods: Five finite element models were established and tested by simulating PLIF surgery at L4/5. They included: (1) normal model (2) osteoporosis model (3) pedicle screw model; (4) cement augmentation pedicle screw（CAPS）model; (5) cortical bone trajectory (CBT) model. The range of motion (ROM), stress of fusion cage and screw-rod system of different models were analyzed by simulating flexion, extension, left bending, right bending, left rotation and right rotation movements through software.Results: The ROM of the osteoporosis model was increased compared with the normal bone, and the osteoporosis was increased by 5.3%, 17.6%, 11.5%, 11.3%, 7.5%, and 8.3% compared with the normal model during flexion, extension, left bending, right bending, left rotation, and right rotation. After fixation, the ROM decreased, but the difference was not significant between the different fixation models. The stress of the screw-rods is the minimum one in the CAPS group. the PS group is the middle one, and stress of the CBT group is max. The cage stress is the minimum in the CAPS group which is slightly smaller than the cage stress in the PS group. the cage stress was the max in the CBT group.Conclusion: PLIF can decrease the ROM of lumbar vertebra and fusion segment in osteoporosis, but different fixation methods have little effect on ROM. However, there was a great difference in the stress of implant, with the least stress in the CAPS group, the second in the PS group, and the greatest stress in the CBT. The same is true for Cage stress. At the same time, the maximum stress zone to occur at the screw-rod junction, while the maximum stress of cage occurs at the position in contact with the endplate. The study has guiding significance for clinical practice.
Determination of Equivalent Mohr-Coulomb Criterion from Generalised Hoek-Brown Criterion
Authors: Yang Qingqing , Cai Fei 
Published: November 2021

Abstract
A new analytical solution is presented for determining equivalent Mohr-Coulomb (MC) shear strength parameters over an arbitrary interval of minor principal stress σ3 from the generalised Hoek-Brown (HB) criterion using least squares method. Comparison with several published examples demonstrates that the proposed solution had a capacity to accurately determine equivalent MC parameters over a given interval of σ3, as well as instantaneous MC parameters by using a very small interval of σ3. EMC parameters depended heavily on the interval of σ3, which highlighted the importance of intervals of σ3. A calculation case shows that the equivalent internal friction angle and cohesion over the interval of σ3 from tension cut-off σcut−off to maximum minor principal stress σ3max were approximately 12% smaller and 10.3% larger than those over an interval from tensile strength to σ3max, respectively. The proposed solution offers great flexibility for the application of the HB criterion with existing methods based on the MC criterion for rock engineering practice.
Long-term persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein-specific and neutralizing antibodies in recovered COVID-19 patients
Authors: Chansaenroj Jira , Yorsaeng Ritthideach , Wanlapakorn Nasamon , Chirathaworn Chintana , Sudhinaraset Natthinee , Sripram Manit , Chalongviriyalert Piti , Jirajariyavej Supunee , Kiatpanabhikul Phatharaporn , Saiyarin Jatuporn , Soudon Chulikorn , Thienfaidee Orawan , Ayuthaya Thitisan Palakawong Na , Brukesawan Chantapat , Intharasongkroh Duangnapa , Chaiwanichsiri Dootchai , Issarasongkhram Mila , Kitphati Rungrueng , Mungaomklang Anek , Thitithanyanont Arunee , Nagavajara Pijaya , Poovorawan Yong 
Published: November 2021

Abstract

Understanding antibody responses after natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can guide the coronavirus disease 2019 (COVID-19) vaccine schedule. This study aimed to assess the dynamics of SARS-CoV-2 antibodies, including anti-spike protein 1 (S1) immunoglobulin (Ig)G, anti-receptor-binding domain (RBD) total Ig, anti-S1 IgA, and neutralizing antibody against wild-type SARS-CoV-2 in a cohort of patients who were previously infected with SARS-CoV-2. Between March and May 2020, 531 individuals with virologically confirmed cases of SARS-CoV-2 infection were enrolled in our immunological study. The neutralizing titers against SARS-CoV-2 were detected in 95.2%, 86.7%, 85.0%, and 85.4% of recovered COVID-19 patients at 3, 6, 9, and 12 months after symptom onset, respectively. The seropositivity rate of anti-S1 IgG, anti-RBD total Ig, anti-S1 IgA, and neutralizing titers remained at 68.6%, 89.6%, 77.1%, and 85.4%, respectively, at 12 months after symptom onset. The half-life of neutralizing titers was estimated at 100.7 days (95% confidence interval = 44.5 – 327.4 days, R2 = 0.106). These results support that the decline in serum antibody levels over time depends on the symptom severity, and the individuals with high IgG antibody titers experienced a significantly longer persistence of SARS-CoV-2-specific antibody responses than those with lower titers.
Bacteria-engineered porous sponge for hemostasis and vascularization
Authors: Bian Jie , Bao Luhan , Gao Xiaokang , Wen Xiao , Zhang Qiang , Huang Jinhua , Xiong Zhenghui , Hong Feng F. , Ge Zili , Cui Wenguo 
Published: November 2021

Abstract
Background
Hemostasis and repair are two essential processes in wound healing, yet early hemostasis and following vascularization are challenging to address in an integrated manner.
Results
In this study, we constructed a hemostatic sponge OBNC-DFO by fermentation of Acetobacter xylogluconate combined with TEMPO oxidation to obtain oxidized bacterial nanocellulose (OBNC). Then angiogenetic drug desferrioxamine (DFO) was grafted through an amide bond, and it promoted clot formation and activated coagulation reaction by rapid blood absorption. The further release of DFO stimulated the secretion of HIF-1α and the reconstruction of blood flow, thus achieving rapid hemostasis and vascularization in damaged tissue. This new hemostatic sponge can absorb approximately 38 times its weight in 28 seconds, rapidly enhancing clot formation in the early stage of hemostasis. In vitro and in vivo coagulation experiments (in rat tail amputation model and liver trauma model) demonstrated superior pro-coagulation effects of OBNC and OBNC-DFO to clinically used collagen hemostatic sponges (COL). They promoted aggregation and activation of red blood cells and platelets with shorter whole blood clotting time, more robust activation of endogenous coagulation pathways and less blood loss. In vitro cellular assays showed that OBNC-DFO prevailed over OBNC by promoting the proliferation of human umbilical vein endothelial cells (HUVECs). In addition, the release of DFO enhanced the secretion of HIF-1α, further strengthening vascularization in damaged skin. In the rat skin injury model, 28 days after being treated with OBNC-DFO, skin appendages (e.g., hair follicles) became more intact, indicating the achievement of structural and functional regeneration of the skin.
Conclusion
This hemostatic and vascularization-promoting oxidized bacterial nanocellulose hemostatic sponge, which rapidly activates coagulation pathways and enables skin regeneration, is a highly promising hemostatic and pro-regenerative repair biomaterial.
Evolution and Dynamics of Quantum Fluids
Authors: Sengupta Sohan 
Published: November 2021

Abstract
Quantum Fluids follow Quantum Dynamical Equation(s), which were not known till date. There exist a set of two equations, that is semiclassical approach to Quantum Fluids called Madelung’s Equations. But a new fully quantum variant of Madelung’s Equations when embedded in the Schrodinger Equation is gives full description of evolution of Quantum fluid with respect to time and position. The equation presented in this article has two unknown variables, one is density and other is velocity field as a function of spatial and time coordinates. The equation presented in this article, is derived from Schrodinger Equation, obeying Continuity equation, and Navier Strokes Equation. Bohm’s potential were externally added in Madeline’s equation. But the new equation which is fully quantum mechanical in nature; Bohm’s potential appears out of the equation, which is interesting to observe. Astrophysical cold stellar dynamics and condensed fluids have the main application of this equation. Quantum fluids show strange behaviour when compared to normal fluids. It is also shown that quantum fluid also have spins which has no classical analog.
Impact of Temperature and Material Variation on Mechanical Properties of Parts Fabricated with Fused Deposition Modelling (FDM) Additive Manufacturing
Authors: Sehhat M. Hossein , Mahdianikhotbesara Ali , Yadegari Farzad 
Published: November 2021

Abstract
Additive Manufacturing (AM) can be deployed for space exploration purposes, such as fabricating different components of robots’ bodies. The produced AM parts should have desirable thermal and mechanical properties to withstand the extreme environmental conditions, including the severe temperature variations on moon or other planets which cause changes in parts’ strengths and may fail their operation. Therefore, the correlation between operational temperature and mechanical properties of AM fabricated parts should be evaluated. In this study, three different types of polymers, including polylactic acid (PLA), polyethylene terephthalate glycol (PETG), and acrylonitrile butadiene styrene (ABS), were used in Fused Deposition Modeling (FDM) process to fabricate several parts. The mechanical properties of produced parts were then investigated at various temperatures to generate knowledge on the correlation between temperature and type of material. When varying the operational temperature during tensile tests, the material’s glass transition temperature was found influential in determining the type of material failure. Among the materials used, ABS showed the best mechanical properties at all temperatures due to its highest glass transmission temperatures. The results of statistical analysis indicated the temperature as the significant factor on tensile strength while the change in material did not show a significant effect.
Binary Tree Based Data Gathering Routing Scheme for Wireless Sensor Networks
Authors: Bathla Gaurav , Pawar Lokesh , Bajaj Rohit 
Published: November 2021

Abstract
Wireless sensor network (WSN) is an emerging area in networking since the era of 21 st century. The major benefits of WSN using sensor nodes make it affordable, scalable, economic and reliable. The limitations of sensor nodes are in terms of fixed and limited power supply, durability, storage and computational facilities which make energy as a vast challenge in deploying sensor nodes in order to prevent them from draining. This paper proposes a novel deployment scheme for connecting the sensor nodes in the form of a 4-sided virtual full binary tree structure. In the proposed scheme, data is expected to reach resource opulence Base Station (BS) via hops as equal to the height of the tree. Also, the stability of the network will increase by an average value of around 82.78% in the range of 49- 98% with existing scheme of the network lifetime with respect to different scenarios. The proposed scheme gives excellent results with a variable number of nodes and changing the size of deployment area of WSN.
Explainable Neural Network Ensembles
Authors: Chakraborty Manomita , Biswas Saroj Kumar , Purkayastha Biswajit 
Published: November 2021

Abstract
Neural networks are known for providing impressive classification performance, and the ensemble learning technique is further acting as a catalyst to enhance this performance by integrating multiple networks. But like neural networks, neural network ensembles are also considered as a black-box because they cannot explain their decision making process. So, despite having high classification performance, neural networks and their ensembles are not suited for some applications which require explainable decisions. However, the rule extraction technique can overcome this drawback by representing the knowledge learned by a neural network in the guise of interpretable decision rules. A rule extraction algorithm provides neural networks with the power to justify their classification responses through explainable classification rules. Several rule extraction algorithms exist to extract classification rules from neural networks, but only a few of them generates rules using neural network ensembles. So this paper proposes an algorithm named Rule Extraction using Ensemble of Neural Network Ensembles (RE-E-NNES) to demonstrate the high performance of neural network ensembles through rule extraction. RE-E-NNES extracts classification rules by ensembling several neural network ensembles. Results show the efficacy of the proposed RE-E-NNES algorithm compared to different existing rule extraction algorithms.
LDES: Detector Design for Version Number Attack Detection using Linear Temporal Logic based on Discrete Event System
Authors: Seth Abhay Deep , Biswas Santosh , Dhar Amit Kumar 
Published: November 2021

Abstract
The Internet Engineering Task Force (IETF) has defined routing protocols for Low Power and Lossy Networks (RPL) for constrained devices. RPL constructs DODAGs (Destination Oriented Directed Acyclic Graphs), to optimize routing. RPL ensures acyclic topology with the DODAG version number. However, the control message's DODAG version number is not authenticated. So, RPL is vulnerable to topological inconsistency attack known as DODAG Version Number (DVN) attack. DVN attack creates a packet delay, packet loss, cyclic topology, etc., in the network. This paper proposes a method for detecting DODAG version number attacks. Several existing schemes to defend against the DVN, such as cryptographic techniques, trust-based, threshold-based and mitigation are computationally intensive or require protocol modification. DVN does not change the packet format or sequence of packets, but can still perform attacks and hence fall under the category of stealthy attacks, which are difficult to detect using traditional Intrusion Detection System$'$s (IDS). Discrete-Event System (DES) based IDS have been applied in the literature for stealthy attacks that achieve low overhead, low false alarm rate, etc. However, the construction of DES-based IDS for network protocol may lead to errors, as modelling is manual. The resulting IDS, therefore, is unable to guarantee its correctness. This paper proposes Linear Temporal Logic (LTL) based DES paradigm to detect DVN. LTL-based paradigm facilitates formal verification of the DES-based IDS, and hence the correctness of the scheme is ascertained. The proposed technique is simulated using the Contiki cooja simulator. When the percentage of spiteful nodes in the network increases, the true positive rate, and packet delivery rate drops, while the false positive rate and control message overhead increase. The memory requirement for sending the packets and verifying the nodes is minimal. The LTL-based IDS has been formally verified using NuSMV to ensure the correctness of the framework.