bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОСОБЕННОСТИ ТЕЧЕНИЯ ПНЕВМОНИИ ПРИ COVID-19 У ДЕТЕЙ
Authors: Руженцова Татьяна , Хавкина Дарья , Попова Раиса , Чухляев Павел , Гарбузов Александр 
Published: July 2021

Цель исследования – изучить особенности клинических проявлений пневмоний, развившихся у детей, больных COVID-19.
Материалы и методы. Проанализированы данные историй болезней 36 детей в возрасте от 8 месяцев до 17 лет, находившихся на лечении в детском инфекционном отделении ГБУЗ МО «МГКБ», г. Мытищи с подтвержденной пневмонией и выявленным SARS-CoV-2 в период с марта по июль 2020 года.
Всем детям в 1-й день госпитализации было проведено обследование: клинический осмотр, пульсоксиметрия, стандартные общеклинические анализы крови и мочи; рентгенологическое исследование органов грудной клетки или КТ органов грудной клетки, биохимический анализ крови; коагулограмма; мазок из носоглотки и ротоглотки на РНК вируса методом ПЦР. Повторные лабораторные и инструментальные исследования проводились по мере необходимости. Из 36 детей большинство пациентов были в возрасте от 8 месяцев до трех лет – 13 человек (36%), с трех до шести лет – 8 человек (22%), с шести до 10 лет – 5 детей (14%), старше 10 лет- 10 детей (28%).
Результаты. Большинство пациентов (96%) имели среднюю степень тяжести заболевания, 4% - легкую. Основными проявлениями были выраженные симптомы интоксикации в виде слабости, сонливости, повышенной утомляемости и снижения аппетита, редкий сухой кашель и повышение температуры тела до субфебрильных цифр (37.3-38.00С). Аускультативно в легких выслушивалось жесткое дыхание (100%), одышка при беспокойстве или физической нагрузке (у 37%), сухие хрипы (чаще в нижних отделах). По локализации превалировала правосторонняя (78%) верхнедолевая (58%) пневмония.
Выводы
1. Клиническая картина пневмонии легкой и средней степени тяжести, возникшая у детей на фоне инфицирования SARS-CoV-2, характеризуется выраженной интоксикацией с отсутствием характерной аускультативной картины.
2. Клинико-лабораторные данные не являются специфичными, по результатам анализа крови чаще выявляется лимфопения с нормальным уровнем лейкоцитов, повышение С-реактивного белка.
ЭПИДЕМИОЛОГИЧЕСКАЯ СИТУАЦИЯ ПО COVID-19 В ИРКУТСКОЙ ОБЛАСТИ И ПРОГНОЗ ЕЕ РАСПРОСТРАНЕНИЯ
Authors: Балахонов Сергей , Чеснокова Маргарита , Пережогин Алексей , Никитин Алексей , Каверзина Светлана , Бренева Наталья , Дугаржапова Зоригма , Савиных Дмитрий , Поталицина Наталья , Гаврилова Татьяна , Лиханова Надежда , Чумаченко Ирина , Хакимова Марьяна 
Published: July 2021

Широкое распространение новой коронавирусной инфекции COVID-19 в Российской Федерации определяет актуальность оценки конкретной территории по ее эпидемиологической значимости.
Цель исследования. Выявление эпидемиологических особенностей и установление тенденций эпидемического процесса новой коронавирусной инфекции COVID-19 в Иркутской области и прогнозирование ее распространения.
Материалы и методы. Проведен оперативный анализ эпидемиологической ситуации по COVID-19 в Иркутской области по состоянию на 16.08.2020 г., обоснованы ограничительные мероприятия на основании расчета коэффициента распространения инфекции (Rt).
Полученные результаты. Иркутская область по заболеваемости людей COVID-19 на 16.08.2020 г. продолжает оставаться одной из неблагополучных территорий в СФО и Российской Федерации. Определена постепенная динамика развития эпидемического процесса, чему способствовали на первом этапе развития эпидемии завозные случаи из неблагополучных стран и регионов Российской Федерации, в последующем − местная передача. Подъем заболеваемости смещен на 2 месяца позже по сравнению с центральными регионами РФ. Рост случаев инфицирования превалировал среди лиц, пребывающих на вахтовые и сезонные работы в административный центр и северные районы Иркутской области. Определен характер по гендерному, возрастному и социальному проявлениям эпидемического процесса. Показано, что риск заболеваемости новой коронавирусной инфекцией определяется интенсивностью контакта в семейных очагах, распространением в медицинских организациях и значительной долей бессимптомного носительства. Установлены высокие показатели летальности (0,7 %) и смертности (31,1 %ооо) среди лиц старше 65 лет. Наблюдаемый с июня стационарный временной ряд изменения Rt-показателя с колебаниями от 0,92 до 1,01 требует сохранения контроля проводимых ограничительных мероприятий с оперативным принятием управленческих решений, исходя из складывающейся эпидемиологической ситуации в Иркутской области и с учетом оценки рисков ее возможного осложнения.
Respiratory Impairment Related To Vaping
Authors: Wysoczańska Anna , Moreira Helena , Barg Ewa 
Published: July 2021

Abstract
The use of electronic cigarettes referred to as “vaping” have a detrimental impact on human health, especially on the respiratory system. Depending on the chemical composition and the frequency and quantity of inhalation exposure, the severity of the symptoms may vary among patients. Here we discuss the main potential triggers for EVALI (e-cigarette or vaping product use-associated lung injury). Some vaping-related cellular response mechanisms, including inflammatory response and oxidative stress, and a correlation between vaping and the susceptibility to respiratory infections (including SARS-CoV-2), are presented. In-depth, long-term studies, especially involving cellular responses, are necessary to fully elucidate the process leading to the onset of EVALI symptoms.
Anosmia in SARS-CoV-2 Patients: a Retrospective Study
Authors: Yee ChenHui , Koh Matthew , Tambyah Paul Anantharajah , Allen David , Somani Jyoti , Wang De Yun , Loh Woei-Shyang 
Published: July 2021

Abstract
BackgroundPost viral anosmia has been reported in human coronavirus infections. In this current pandemic, olfactory dysfunction (OD) has emerged as a common key presenting symptom of COVID-19 infection. In this study, we describe OD assessment in the inpatient setting of patients both suspected of and with confirmed COVID-19 infection via University of Pennsylvania Smell Identification Test (UPSIT) objective assessment and a simple self-reported 3-item questionnaire.MethodsThirty patients admitted to the isolation wards of the National University Hospital, Singapore for either suspected or confirmed COVID-19 infection from April to May 2020 were recruited to this study. 10 patients who tested negative for SARS-CoV-2 were recruited as control subjects. The 20 patients with COVID-19 infection were divided into two groups (10 had olfactory testing performed during the first week of illness, 10 in the second week of illness). A simple 3-question survey was administered to each participant - to rank the severity, state the onset and duration of their hyposmia. Olfactory testing was performed using an English version of the UPSIT.ResultsLoss of smell was reported in 2 participants from the control group, 6 participants from the in the first week of illness and 5 participants from the second week of illness. Two COVID-19 patients have anosmia on the UPSIT. COVID-19 patients were more likely to have severe hyposmia or anosmia by objective assessment, a difference that was statistically significant (P = 0.0485). The differences in degree of OD among COVID-19 patients in their first and second week of illness were not statistically significant (P= 0.6563).ConclusionSelf-reported anosmia was higher among COVID-19 patients compared to controls who were admitted to isolation wards for respiratory symptoms but were tested negative for SARS-CoV-2 infection. On objective assessment by the UPSIT, COVID-19 patients were found to have higher rates of severe hyposmia or anosmia, a difference that was statistically significant (P = 0.0485). A limitation of this study is the odorants used in UPSIT which may be less familiar to the primarily Asian participants in this study, owing to cultural differences.
Dental pulp stem cells as a therapy for congenital entero-neuropathy
Authors: Kajioka Shunichi , Yoshizumi Junko , Oda Yoshinao , Iwata Naoko , Takai Chiho , Nakayama Shinsuke , Yoshimaru Koichiro , Yamaza Takayoshi , Sonoda Soichiro , Yanagi Yusuke , Taguchi Tomoaki , Matsuura Toshiharu 
Published: July 2021

Abstract
Hirschsprung’s disease (HSCR) and its allied disorders are congenital entero-neuropathies with life-long implications in many cases. Here we report the effects of intravenous transplantation of cultured dental pulp stem cells derived from deciduous teeth (dDPSCs) into ‘Japanese fancy-1’ (JF1) mice with entero-neuropathy caused by Ednrb mutation. Intravenously injected dDPSCs (multipotent neural crest cells with low immunogenicity) migrated to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Notably, transplanted dDPSCs differentiated into both enteric neurons and pacemaker interstitial cells to correct abnormalities in the electrical and mechanical activities of the proximal colon. dDPSC transplantation also led to repair of the small intestinal mucosa, changes in the gastrointestinal microbiota, improvements in nutritional status and prolongation of survival. We anticipate that dDPSC transplantation could be developed into a novel cell-based therapy for HSCR and its allied disorders.
Intraspecific Variation In Plant Economic Traits Predicts Trembling Aspen Resistance To A Generalist Insect Herbivore
Authors: Morrow Clay J. , Jaeger Samuel J. , Lindroth Richard L. 
Published: July 2021

Abstract
Patterns of trait expression within some plant species have recently been shown to follow patterns described by the leaf economics spectrum paradigm. Resistance to herbivores is also expected to covary with leaf economics traits. We selected multiple mature Populus tremuloides genotypes from a common garden to assess whether aspen leaf economics patterns follow those observed among species globally. We also evaluated leaf economics strategies in the context of insect resistance by conducting bioassays to determine the effects of plant traits on preference and performance of Lymantria dispar. We found that: 1) intraspecific trait patterns of P. tremuloides parallel those exhibited by the interspecific leaf economics spectrum, 2) herbivores preferred leaves from genotypes with resource-acquisitive strategies, and 3) herbivores also performed best on genotypes with resource-acquisitive strategies. We conclude that a leaf economics spectrum that incorporates defense traits is a useful tool for explaining intraspecific patterns of variation in plant strategies, including resistance to herbivores.
Relationships Between Dietary Patterns And Low Level Lead Exposure Among Children From Hunan Province of China
Authors: Huang Zhi , Yin Xico-chen , Chen Ming , Li Mei-ling , Chen Bo , Hu Yu-ming 
Published: July 2021

Abstract
Background: Lead (Pb) is a potent environmental toxic metal. Few studies have focused on low-level Pb exposure in children. This study evaluated the relationships of dietary patterns with low-level Pb exposure in children from Hunan province of China.Methods: A cross-sectional study was conducted in a single primary school, located in Hunan Province. In total, 425 children were recruited. Principal component analysis was used to identify dietary patterns based on dietary intake from a food frequency questionnaire (FFQ). The blood lead level (BLLs) was measured. Multivariate regression analysis was used to investigate the correlations of BLLs with dietary patterns. Results: Three dietary patterns were identified: balanced, plant, and beverage and snack. The concentration of blood lead (median (IQR)) was 2 (2, 15.96) μg /L. Only 0.24% children’s BLLs were >100 µg/L and 1.18% children’s BLLs were >50 µg/L. No significant risk association was found between dietary patterns and BLLs by logistic regression analysis based on 50th percentile (P50) of blood lead. However, children’s gender of girl decreased the risk of BLLs (AOR=0.57, 95% CI: 0.38, 0.85, P=0.006). The plant pattern had weekly positive association with log-Pb (B=0.04, 95% CI: 0.00, 0.08, P=0.035) in group of > P50 by linear regression analysis.Conclusions: BLLs was low among children aged 4–7 years in Hunan province of China. Low BLLs had no association with dietary pattern, mediated by some confounding factors, such as gender. However, diet may become an important source of blood lead with increasing blood lead levels.
Lower Serum Dipeptidyl peptidase-Ⅳ Level is Associated With 3 Types of Autoimmune Thyroid Diseases
Authors: zhang Yuanyuan , Fu Ying , Yang Yuxian , Song Jing , Zhao Dong 
Published: July 2021

Abstract
Backgroud:

Autoimmune thyroid diseases (AITD) are the most common organ specific autoimmune disorders. The reduction of serum dipeptidyl peptidase-IV (sDPPIV) levels have been reported in patients with autoimmune diseases. Few studies have analyzed the association between sDPPIV levels and AITD, especially in Graves’ disease (GD), Graves’ ophthalmopathy (GO) patients. So the aim of this study was to evaluate the association between sDPP-IV levels and 3 types of AITD, that is Graves’ disease (GD), Graves’ ophthalmopathy (GO), Hashimoto’s thyroiditis (HT).
Methods

65 newly diagnosed GD ,22 GO, 27 HT patients and 30 healthy individuals were recruited for this study. Clinical characteristics and thyroid function data were collected for all participants. sDPP-IV was measured by enzyme-linked immunosorbent assay.
Results

Compared with the controls, GD patients and GO patients had significantly lower sDPP-IV levels(662.2 ± 38.81 and 438.4 ± 31.78 vs.786.3 ± 46.95, P = 0.01 or P < 0.001). It was also found that in GO individuals, sDPP-IV was lower than in GD subjects(P = 0.002). The lower the sDPP-IV level is, the higher the risk for developing GD or GD will be. In addition, sDPP-IV levels have negative association with the antithyroid peroxidase antibody(TGab)(r =-0.20, p = 0.02) and antithyroglobulin antibody(TPOab)(r =-0.19, p = 0.03). But there was no significant relationship between thyroid hormone and sDPP-IV levels.GO parients were groups by proptosis with and without muscle thicken,the sDPP-IV levels in proptosis with muscle thicken were lower than proptosis without muscle thicken(P < 0.05).Logistic regression analysis showed that sDPP4 were negatively correlated with GO and GD.
Conclusions

Take together, the present study showed for the first time that sDPP-IV concentrations are aberrant in GD and GO patients and that the reduced sDPP-IV expression may be involved in the progression of GO and GD diseases.
Differences in Immune Indicators and Prognosis Between IgG4-Positive and Negative Lacrimal Gland Benign Lymphoepithelial Lesion
Authors: Liu Rui , Wang Nan , Wang Jinjin , Li Jing , Ge Xin , Zhang Jingxue , Ma Jianmin 
Published: July 2021

Abstract
Purpose: The differences in immune indicators and prognosis between IgG4-positive and negative lacrimal gland benign lymphoepithelial lesion (LGBLEL) were analyzed.Methods: This was a single-center retrospective clinical study. Clinical data of 146 patients with LGBLEL were collected from June 2011 to June 2019. Results: The age, preoperative glucocorticoid history, and serum C3, C4, IgG, IgG2, IgG4 had statistical difference between the IgG4-positive and negative groups (P<0.05). The expression levels of IgG and IgG4 in the IgG-positive group with preoperative glucocorticoid therapy were lower than those in the IgG4-negative group without preoperative glucocorticoid therapy (P=0.021 and P=0.013). The 5-year recurrence-free cumulative percentages of IgG4-positive group was 81.85%, and 83.46% in the IgG-negative group, which had no statistical difference (P=0.216). The history of preoperative glucocorticoid therapy, serum C4, IgG1 and IgG2 were the factors affecting IgG4-positive LGBLEL’ recurrence, while the history of preoperative glucocorticoid therapy, serum C4, and IgG1 were the factors affecting LGBLEL’ recurrence (P<0.05).Conclusion: Serum C3, C4, IgG, IgG2, IgG4 had statistical difference between the IgG4-positive and negative LGBLEL. The history of preoperative glucocorticoid therapy, serum C4 and IgG1 were the factors affecting LGBLEL’ recurrence, while the expression level of IgG4 was not the factor affecting LGBLEL’ recurrence.
Enhanced Recovery After Surgery (ERAS) for Hysterectomy - A Systematic Review
Authors: O'Sullivan Sarah Louise , Iranloye Rhoda 
Published: July 2021

Abstract
Purpose: Enhanced Recovery After Surgery (ERAS) is an evidence-based recovery programme that aids in the recovery time following major surgery to improve clinical outcomes while reducing demand on impatient beds. Previous studies from multiple specialities have demonstrated positive effects of ERAS, including colorectal, liver and pancreatic surgery with ERAS pathways becoming part of normal practice. The aim of this study was to systematically review the impact of ERAS in hysterectomy for benign conditions. Methods: A comprehensive literature search was undertaken using CINAHL, EMBASE and PubMed using the search terms ‘Multi-modal’ or ‘fast track’ or ‘ERAS’ or ‘enhanced recovery’ or ‘same day discharge’ and ‘hysterectomy. In accordance with the PRISMA checklist, articles were selected for inclusion based on predetermined criteria, and a narrative synthesis was used to systematically review the selected articles. Results: Eight articles describing the use of ERAS protocols in hysterectomy for benign conditions were identified. Three were cohort studies, three randomised controlled trials (RCTs) and two case-control studies. While there were no significant differences in postoperative pain, patient satisfaction, postoperative complications, or readmissions between groups, length of stay and cost were both decreased in the ERAS groups. Conclusions: The use of ERAS protocols for hysterectomy resulted in reduced length of stay without increasing rates of complications or readmissions.
Morindone From Morinda Citrifolia as a Potential Antiproliferative Agent Against Colorectal Cancer Cell Lines
Authors: Chee Cheok Wui , Zamakshshari Nor hisam , Lee Vannajan , Abdullah Iskandar , Othman Rozana , Lee Yean Kee , Hashim Najihah Mohd , Rashid Nurshamimi Nor 
Published: July 2021

Abstract
There is an increasing demand in developing new, effective, and affordable anti-cancer against colon and rectal. In this study, our aim is to identify the potential anthraquinone compounds from the root bark of Morinda citrifolia to be tested in vitro against colorectal cancer cell lines. Eight potential anthraquinone compounds were successfully isolated, purified and tested for both in-silico and in-vitro analyses. Based on the in-silico prediction, two anthraquinones, morindone and rubiadin, exhibit a comparable binding affinity towards multitargets of β-catenin, MDM2-p53 and KRAS. Subsequently, we constructed a 2D interaction analysis based on the above results and it suggests that the predicted anthraquinones from Morinda citrifolia offer an attractive starting point for potential antiproliferative agents against colorectal cancer. In vitro analyses further indicated that morindone and damnacanthal have significant cytotoxicity effect and selectivity activity against colorectal cancer cell lines.
Predictive Factors Related To Brucellosis Prevention Among Livestock Farmers Based on The PRECEDE-PROCEED Model
Authors: kalan Ebrahim , Narimani Sajjad , Maleki Ali , Zarehoseinzadeh Elham , Shaker Hamidreza , Ahmadi Fatemeh 
Published: July 2021

Abstract
Brucellosis is one of the most common zoonotic diseases that wreaking havoc on economy of rural communities and society in general. In this study we sought to determine the predictive factors related to brucellosis prevention among livestock farmers in rural areas of Germi county. In a cross-sectional analytical study, 365 Livestock farmers in villages of Germi were selected using cluster sampling. Educational needs assessment about brucellosis were assessed using the questionnaire comprising 4 modules; first module included demographic characteristics and other 3 modules assessed the components of PRECEDE-PROCEED Model (i.e., predisposing factors, enabling factors, and Reinforcement factors). A high average (M = 64.5 ± 6) knowledge about the transmission of brucellosis was observed among livestock farmers. However, the mean of attitude scores (about the regular visit of animals by the veterinarian and the effects of the disease on health status) were low (M = 27 ± 3.3). Enabling factors (having protective equipment, access to pasteurized dairy products, keeping livestock outside the village and vaccination of livestock) had the low average (M = 35 ± 8.7). Enabling factors and reinforcement factors were strongly correlated (r = 0.338,p = 0.001). This study indicated that increasing of enabling factors can lead to livestock empowerment and brucellosis prevention among them in rural areas of Germi county.
Identification of an E2F Target‐Related Gene Signature to Improve the Prognosis Prediction for Patients with Hepatocellular Carcinoma
Authors: Bian Jing , Chen Xi , Jiang Mingyan , Gao Xinghua 
Published: July 2021

Abstract
Liver cancer is one of the most common malignant tumors in the world, of which hepatocellular carcinoma (HCC) is the most common histological subtype. Although thousands of biomarkers related to HCC survival and prognosis have been found through database mining, the predictive effects of single-gene biomarkers are not specific enough. Therefore, we aimed to construct a pathway-related signature that could effectively forecast HCC prognosis. We obtained gene expression data and clinical patient information from The Cancer Genome Atlas database (TCGA). Univariate and multivariate Cox regression analyses were used to identify genes enriched in the E2F target gene pathway by Gene Set Enrichment Analysis. In the training set, NBN, PHF5A, CDCA8, AK2, and EXOSC8 were significantly associated with overall survival. They were validated in the test and entire groups, confirmed by Gene Expression Omnibus (GEO), and compared with two known prognostic signatures for HCC. Overall, we demonstrated a novel five-mRNA prognostic signature based on E2F targets that successfully predicted the survival of HCC patients, is independent of clinicopathological data, and displayed superior prediction performance in HCC prognosis. Our study elucidates the cell cycle mechanism in identifying patients with poor HCC prognosis. The application of our five-mRNA prognostic signature may improve risk stratification in HCC patients and existing methods for survival prediction.