bluuebunny/crossref_metadata_2025_split huggingface dataset:
What exactly is Takeuchi Yoshimi's logic of Asian resistance?
Authors: Stromback Dennis 
Published: September 2021

AbstractLiterary Critic and Sinologist, Takeuchi Yoshimi, provides post-colonial and decolonial studies a logic of resistance that seeks to destabilize the colonialist projects of Western modernity without repeating its structural logic. In this regard, Takeuchi's logic of resistance functions as a dialectical lens into the “emancipatory traps” of Western modernity that frame the victim–victimizer paradox by turning negativity into a method of generating heuristic possibilities. But in this pursuit to look for alternative sites for mining theoretical possibilities, Takeuchi returns to the origins of Chinese modernity for imagining a proper logic of Asian resistance, that which could be deployed as a resource for negating the imperial gestures of modernist thought while affirming the positive kernel of the Enlightenment with the hope of bringing forth a global world that is continuously transformed by the cultural particulars themselves. The goal of this article is to further elucidate Takeuchi's logic of Asian resistance and to discuss how this logic can be read as having the potential to correct Nishida Kitarō's and the Kyoto School's failed attempt to overcome modernity.
The Merluza Graben: How a Failed Spreading Center Influenced Margin Structure, and Salt Deposition and Tectonics in the Santos Basin, Brazil
Authors: Pichel Leonardo M. , Jackson Christopher A.‐L. , Peel Frank , Ferrer Oriol 
Published: September 2021

AbstractThe relative timing between crustal extension and salt deposition can vary spatially along passive margin salt basins as continents unzip, or as the locus of extension shifts toward the embryonic ocean spreading center. Determining the relative timing of salt deposition, rifting, and seafloor spreading is often problematic due to the diachronous nature of rifting, the ability of salt to fill pre‐existing topography, and the subsequent flow and deformation of that salt. We here use 2D PSDM seismic data and structural restorations to investigate the Merluza Graben, a large rift‐related depocentre located in the southern, most proximal part of the Santos Basin, Brazil, along‐strike of a failed spreading center, the Abimael Ridge. The graben is defined by up to 3.5 km of base‐salt relief along its basinward‐bounding fault and internal base‐salt horsts that are up to 1 km high. This compartmentalizes deformation, producing intra‐graben extensional and contraction salt structures, ramp‐syncline basins, and expulsion rollovers, resulting in a remarkably different salt‐tectonic structural style to that seen in the adjacent areas. We also conduct structural restorations to analyze the spatial and temporal evolution of salt‐tectonic structural styles and the relationship this has to potential prolonged crustal extension in the Merluza Graben. This approach further constrains local variations in the relative timing of rifting and salt deposition, and the impact this has on salt tectonics along the margin. The results of our study can be applied to better understand the tectono‐stratigraphic development of other salt‐bearing rifted margins.
Isolated Cavities Dominate Greenland Ice Sheet Dynamic Response to Lake Drainage
Authors: Mejia J. Z. , Gulley J. D. , Trunz C. , Covington M. D. , Bartholomaus T. C. , Xie S. , Dixon T. H. 
Published: September 2021

AbstractSeasonal variability in the Greenland Ice Sheet's (GrIS) sliding speed is regulated by the response of the subglacial drainage system to meltwater inputs. However, the importance of channelization relative to the dewatering of isolated cavities in controlling seasonal ice deceleration remains unsolved. Using ice motion, moulin hydraulic head, and glaciohydraulic tremor measurements, we show the passing of a subglacial floodwave triggered by upglacier supraglacial lake drainages slowed sliding to wintertime background speeds without increasing the hydraulic capacity of the moulin‐connected drainage system. We interpret these results to reflect an increase in basal traction caused by the dewatering of isolated cavities. These results suggest the dewatering of isolated parts of the subglacial drainage system play a key role in driving seasonal slowdowns on the GrIS.
When and Where do Free Bars in Estuaries and Tidal Channels Form?
Authors: Ragno Niccolò , Tambroni Nicoletta , Bolla Pittaluga Michele 
Published: September 2021

AbstractThe incipient formation of free bars in weakly converging tidal channels and estuaries is mathematically framed within a unified two‐dimensional shallow water and sediment mass balance model. The analysis is driven by the recognition that none of the theoretical models introduced so far account for the spatially varying character of the planform morphology, which characterizes estuaries and creeks forming networks in coastal wetlands and in the tide‐dominated reaches of deltas. The problem is tackled by means of a linear stability analysis, by observing that width variations act on a spatial scale that is typically much longer than bars wavelength, allowing for an analytical treatment of the governing system of equations. We focus on two limit cases: first, the river transition into a micro‐tidal sea (estuarine case); second, a tidal channel in the absence of a fluvial supply of freshwater and sediment (coastal case). In the estuarine case, bars arise as a result of an intrinsic instability of the equilibrium state. Width increases toward the mouth leading to channel shallowing, which in turn promotes the development of multiple bars. This effect is partially counteracted by the channel deepening produced by the tidal action, which tends to reduce bar growth and migration rate. In the coastal case, tidal bars form far from the equilibrium state of the system, adapting instantaneously to the evolving bed profile, which in turn affects channel flow conditions. Noteworthy, the model suggests that the spatial‐temporal distribution of bars observed in nature reflects the evolutionary history of the system.
Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2
Authors: Liu Zundong , Sang Xiaolin , Wang Min , Liu Yichao , Liu Jiao , Wang Xuefei , Liu Pixu , Cheng Hailing 
Published: September 2021

AbstractComplete blockade of the HER2 protein itself and HER signaling network is critical to achieving effective HER2-targeted therapies. Despite the success of HER2-targeted therapies, the diseases will relapse in a significant fraction of patients with HER2+ breast cancers. How to improve the therapeutic efficacy of existing HER2-targeted agents remains an unmet clinical need. Here, we uncover a role of Melatonin in diminishing HER2-mediated signaling by destruction of HER2 protein. Mechanistically, Melatonin treatment attenuated the protective effect of the HSP90 chaperone complex on its client protein HER2, triggering ubiquitylation and subsequent endocytic lysosomal degradation of HER2. The inhibitory effect of Melatonin on HER2 signaling substantially enhanced the cytotoxic effects of the pan-HER inhibitor Neratinib in HER2+ breast cancer cells. Lastly, we demonstrate that dual inhibition of HER2 by combined use of Melatonin and Neratinib effectively blocked the growth of HER2+ breast tumor xenografts in vivo. Our findings shed light on the potential use of Melatonin in a novel dual HER2 blockade strategy for HER2+ breast cancer treatment.
Substance and Internet use during the COVID-19 pandemic in China
Authors: Huang Qiuping , Chen Xinxin , Huang Shucai , Shao Tianli , Liao Zhenjiang , Lin Shuhong , Li Yifan , Qi Jing , Cai Yi , Shen Hongxian 
Published: September 2021

AbstractThe coronavirus disease 2019 (COVID-19) has adversely influenced human physical and mental health, including emotional disorders and addictions. This study examined substance and Internet use behavior and their associations with anxiety and depression during the COVID-19 pandemic. An online self-report questionnaire was administered to 2196 Chinese adults between February 17 and 29, 2020. The questionnaire contained the seven-item Generalized Anxiety Disorder Scale (GAD-7) and Patient Health Questionnaire (PHQ-9), questions on demographic information, and items about substance and Internet use characteristics. Our results revealed that males consumed less alcohol (p < 0.001) and areca-nut (p = 0.012) during the pandemic than before the pandemic. Age, gender, education status, and occupation significantly differed among increased substance users, regular substance users, and nonsubstance users. Time spent on the Internet was significantly longer during the pandemic (p < 0.001) and 72% of participants reported increased dependence on the Internet. Compared to regular Internet users, increased users were more likely to be younger and female. Multiple logistic regression analysis revealed that age <33 years (OR = 2.034,p < 0.001), increased substance use (OR = 3.439,p < 0.001), and increased Internet use (OR = 1.914,p < 0.001) were significantly associated with depression. Moreover, anxiety was significantly related to female gender (OR = 2.065,p < 0.001), “unmarried” status (OR = 1.480,p = 0.017), nonstudents (OR = 1.946–3.030,p = 0.001), and increased substance use (OR = 4.291,p < 0.001). Although there was a significant decrease in social substance use during the pandemic, more attention should be paid to increased Internet use. Increased Internet use was significantly associated with both anxiety and depression, and increased substance use was related to depression. Professional support should be provided to vulnerable individuals to prevent addiction.
SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury
Authors: Lv Lin-Li , Wang Cui , Li Zuo-Lin , Cao Jing-Yuan , Zhong Xin , Feng Ye , Chen Jun , Tang Tao-Tao , Ni Hai-Feng , Wu Qiu-Li , Wang Bin , Lan Hui-Yao , Liu Bi-Cheng 
Published: September 2021

AbstractTubules injury and immune cell activation are the common pathogenic mechanisms in acute kidney injury (AKI). However, the exact modes of immune cell activation following tubule damage are not fully understood. Here we uncovered that the release of cytoplasmic spliceosome associated protein 130 (SAP130) from the damaged tubular cells mediated necroinflammation by triggering macrophage activation via miRNA-219c(miR-219c)/Mincle-dependent mechanism in unilateral ureteral obstruction (UUO) and cisplatin-induced AKI mouse models, and in patients with acute tubule necrosis (ATN). In the AKI kidneys, we found that Mincle expression was tightly correlated to the necrotic tubular epithelial cells (TECs) with higher expression of SAP130, a damaged associated molecule pattern (DAMP), suggesting that SAP130 released from damaged tubular cells may trigger macrophage activation and necroinflammation. This was confirmed in vivo in which administration of SAP130-rich supernatant from dead TECs or recombinant SAP130 promoted Mincle expression and macrophage accumulation which became worsen with profound tubulointerstitial inflammation in LPS-primed Mincle WT mice but not in Mincle deficient mice. Further studies identified that Mincle was negatively regulated via miR-219c-3p in macrophages as miR-219c-3p bound Mincle 3′-UTR to inhibit Mincle translation. Besides, lentivirus-mediated renal miR-219c-3p overexpression blunted Mincle and proinflammatory cytokine expression as well as macrophage infiltration in the inflamed kidney of UUO mice. In conclusion, SAP130 is released by damaged tubules which elicit Mincle activation on macrophages and renal necroinflammation via the miR-219c-3p-dependent mechanism. Results from this study suggest that targeting miR-219c-3p/Mincle signaling may represent a novel therapy for AKI.
Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes
Authors: Lee Kyu Hyun , Ni Yu-Li , Colonell Jennifer , Karsh Bill , Putzeys Jan , Pachitariu Marius , Harris Timothy D. , Meister Markus 
Published: September 2021

AbstractState-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically many fewer wires carrying signals off the probe, which restricts the number of channels that can be recorded simultaneously. To overcome this fundamental constraint, we propose a method called electrode pooling that uses a single wire to serve many recording sites through a set of controllable switches. Here we present the framework behind this method and an experimental strategy to support it. We then demonstrate its feasibility by implementing electrode pooling on the Neuropixels 1.0 electrode array and characterizing its effect on signal and noise. Finally we use simulations to explore the conditions under which electrode pooling saves wires without compromising the content of the recordings. We make recommendations on the design of future devices to take advantage of this strategy.
Spin-valley coupling in single-electron bilayer graphene quantum dots
Authors: Banszerus L. , Möller S. , Steiner C. , Icking E. , Trellenkamp S. , Lentz F. , Watanabe K. , Taniguchi T. , Volk C. , Stampfer C. 
Published: September 2021

AbstractUnderstanding how the electron spin is coupled to orbital degrees of freedom, such as a valley degree of freedom in solid-state systems, is central to applications in spin-based electronics and quantum computation. Recent developments in the preparation of electrostatically-confined quantum dots in gapped bilayer graphene (BLG) enable to study the low-energy single-electron spectra in BLG quantum dots, which is crucial for potential spin and spin-valley qubit operations. Here, we present the observation of the spin-valley coupling in bilayer graphene quantum dots in the single-electron regime. By making use of highly-tunable double quantum dot devices we achieve an energy resolution allowing us to resolve the lifting of the fourfold spin and valley degeneracy by a Kane-Mele type spin-orbit coupling of ≈ 60 μeV. Furthermore, we find an upper limit of a potentially disorder-induced mixing of the $$K$$
K
and $$K^{\prime}$$

K

′

states below 20 μeV.
Proposal for a continuous wave laser with linewidth well below the standard quantum limit
Authors: Liu Chenxu , Mucci Maria , Cao Xi , Dutt M. V. Gurudev , Hatridge Michael , Pekker David 
Published: September 2021

AbstractDue to their high coherence, lasers are ubiquitous tools in science. We show that by engineering the coupling between the gain medium and the laser cavity as well as the laser cavity and the output port, it is possible to eliminate most of the noise due to photons entering as well as leaving the laser cavity. Hence, it is possible to reduce the laser linewidth by a factor equal to the number of photons in the laser cavity below the standard quantum limit. We design and theoretically analyze a superconducting circuit that uses Josephson junctions, capacitors and inductors to implement a microwave laser, including the low-noise couplers that allow the design to surpass the standard quantum limit. Our proposal relies on the elements of superconducting quantum information, and thus is an example of how quantum engineering techniques can inspire us to re-imagine the limits of conventional quantum systems.
Deep learning framework for material design space exploration using active transfer learning and data augmentation
Authors: Kim Yongtae , Kim Youngsoo , Yang Charles , Park Kundo , Gu Grace X. , Ryu Seunghwa 
Published: September 2021

AbstractNeural network-based generative models have been actively investigated as an inverse design method for finding novel materials in a vast design space. However, the applicability of conventional generative models is limited because they cannot access data outside the range of training sets. Advanced generative models that were devised to overcome the limitation also suffer from the weak predictive power on the unseen domain. In this study, we propose a deep neural network-based forward design approach that enables an efficient search for superior materials far beyond the domain of the initial training set. This approach compensates for the weak predictive power of neural networks on an unseen domain through gradual updates of the neural network with active transfer learning and data augmentation methods. We demonstrate the potential of our framework with a grid composite optimization problem that has an astronomical number of possible design configurations. Results show that our proposed framework can provide excellent designs close to the global optima, even with the addition of a very small dataset corresponding to less than 0.5% of the initial training dataset size.
Nanosilica modified with polyaspartic acid as an industrial circulating water scale inhibitor
Authors: Cheng Yamin , Guo Xinyu , Zhao Xiaowei , Wu Yufeng , Cao Zhongyan , Cai Yonghong , Xu Ying 
Published: September 2021

AbstractGiven the special performance of nanosilica with its small size, large specific surface area and high surface activity, nanosilica containing reactive amino group (denoted as SiO2–NH2) and polysuccinimide were allowed to take part in polymerization reaction to afford SiO2–NH2 modified polyaspartic acid (denoted as SiO2–NH2/PASP), a potential polymer scale inhibitor with good water solubility for industrial circulating water. The scale inhibition performance of the as-prepared SiO2–NH2/PASP was evaluated by static scale inhibition test; and its scale inhibition mechanism was explored by means of scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Results indicated that SiO2–NH2/PASP exhibits excellent scale inhibition performance against CaSO4 and CaCO3 at very low concentrations (optimum scale inhibition rate of 100% and 68%, respectively), and the presence of 5 mg/L of SiO2–NH2/PASP greatly increases the inhibition efficiency of CaSO4 and CaCO3 scale by 21% and 53%, obviously higher than that of pure PASP.
Optical read-out of Coulomb staircases in a moiré superlattice via trapped interlayer trions
Authors: Baek Hyeonjun , Brotons-Gisbert Mauro , Campbell Aidan , Vitale Valerio , Lischner Johannes , Watanabe Kenji , Taniguchi Takashi , Gerardot Brian D. 
Published: September 2021

AbstractMoiré patterns with a superlattice potential can be formed by vertically stacking two layered materials with a relative twist or lattice constant mismatch. In transition metal dichalcogenide-based systems, the moiré potential landscape can trap interlayer excitons (IXs) at specific atomic registries. Here, we report that spatially isolated trapped IXs in a molybdenum diselenide/tungsten diselenide heterobilayer device provide a sensitive optical probe of carrier filling in their immediate environment. By mapping the spatial positions of individual trapped IXs, we are able to spectrally track the emitters as the moiré lattice is filled with excess carriers. Upon initial doping of the heterobilayer, neutral trapped IXs form charged IXs (IX trions) uniformly with a binding energy of ~7 meV. Upon further doping, the empty superlattice sites sequentially fill, creating a Coulomb staircase: stepwise changes in the IX trion emission energy due to Coulomb interactions with carriers at nearest-neighbour moiré sites. This non-invasive, highly local technique can complement transport and non-local optical sensing techniques to characterize Coulomb interaction energies, visualize charge correlated states, or probe local disorder in a moiré superlattice.
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism
Authors: Rao Qinhui , Han Long , Wang Yue , Chai Pengxin , Kuo Yin-wei , Yang Renbin , Hu Fangheng , Yang Yuchen , Howard Jonathon , Zhang Kai 
Published: September 2021

AbstractThousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Coordination among multiple OADs is essential for generating mechanical forces to bend microtubule doublets (MTDs). Using electron microscopy, we determined high-resolution structures ofTetrahymena thermophilaOAD arrays bound to MTDs in two different states. OAD preferentially binds to MTD protofilaments with a pattern resembling the native tracks for its distinct microtubule-binding domains. Upon MTD binding, free OADs are induced to adopt a stable parallel conformation, primed for array formation. Extensive tail-to-head (TTH) interactions between OADs are observed, which need to be broken for ATP turnover by the dynein motor. We propose that OADs in an array sequentially hydrolyze ATP to slide the MTDs. ATP hydrolysis in turn relaxes the TTH interfaces to effect free nucleotide cycles of downstream OADs. These findings lead to a model explaining how conformational changes in the axoneme produce coordinated action of dyneins.
Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity
Authors: Cimino Irene , Rimmington Debra , Tung Y. C. Loraine , Lawler Katherine , Larraufie Pierre , Kay Richard G. , Virtue Samuel , Lam Brian Y. H. , Fagnocchi Luca , Ma Marcella K. L. , Saudek Vladimir , Zvetkova Ilona , Vidal-Puig Antonio , Yeo Giles S. H. , Farooqi I. Sadaf , Pospisilik J. Andrew , Gribble Fiona M. , Reimann Frank , O’Rahilly Stephen , Coll Anthony P. 
Published: September 2021

AbstractNeuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/−p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/−p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30 °C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/−p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/−p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin deficiency on energy expenditure. Male and female Nnat+/−p mice displayed subtle distinctions in the degree of variance body weight phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/−p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals.