bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN METODE KARYA WISATA DALAM PEMBELAJARAN TEMATIK UNTUK MENINGKATKAN PRESTASI BELAJAR IPA SISWA KELAS 1.C SD NEGERI 9 AMPENAN
Authors: Surianah Surianah 
Published: September 2021

Penelitian ini dilatar belakangi oleh rendahnya prestasi belajar siswa kelas 1.C SD Negeri 9 Ampenan pada semester I Tahun Pelajaran 2018/2019 yang disebab kan oleh sulitnya siswa memahami materi yang ada pada mata pelajaran IPA. Tujuan penelitian ini adalah untuk meningkatkan prestasi belajar IPA pada siswa kelas 1.C SD Negeri 9 Ampenan pada semester I Tahun Pelajaran 2018/2019. Instrumen yang digunakan dalam penelitian ini adalah tes prestasi belajar yang dianalisis secara deskriptif.Hasil tes kemampuan awal siswa menunjukkan nilai rata-rata kelas baru mencapai 57,60 dengan presentase ketuntasan belajar sebesar 28%. Hasil tersebut menunjukkan prestasi belajar IPA siswa masih rendah. Setelah diterapkannya metode karya wisata dalam pembelajaran tematik, nilai siswa pada siklus I mencapai 59,20 dengan presentase ketuntasan beajar sebesar 36%. Sedangkan nilai rata-rata di siklus II meningkat menjadi 82,00 dengan presentase ketuntasan belajar mencapai 96%.Hasil yang diperoleh menunjukan adanya peningkatan setelah menggunakan metode karya wisata dalam pembelajaran tematik dan indikator keberhasilan penelitian di capai pada siklus II. Hasil yang telah iperoleh menunjukan bahwa penggunaan metode karya wisata dalam pembelajaran tematik terbukti dapat meningkat kanprestasi belajar siswa pada mata pelajaran IPA. Untuk itu disarankan metode karya wisata dalam pembelajaran temetik dapat dipertimbangkan digunakan dalam pembelajaran dikelas.
PENGGUNAAN METODE SAS DENGAN MEDIA KARTU HURUF UNTUK MENINGKATKAN KETERAMPILAN MEMBACA LANCAR PADA SISWA KELAS 1.C SD NEGERI 9 AMPENAN
Authors: Surianah Surianah 
Published: September 2021

Tujuan dari penelitian ini adalah upaya untuk meningkatkan kemampuan membaca siswa kelas 1.C SD Negeri 9 Ampenan, Membaca adalah hal yang di dahulukan karena, dengan membaca anak mulai belajar secara mandiri dengan lebih dini. Tanpa memiliki kemampuan membaca dan menulis yang memadai sejak dini, anak akan mengalami kesulitan belajar di kemudian hari. Dengan membaca kita bisa melihat dunia, dimana kita ketahui kata Belajar merupakan akibat adanya intraksi antara stimulus dan respon. Untuk itu tujuan penelitian ini untuk meningkatkan keterampilan membaca pada siswa kelas satu dengan menggunakan metode sas dengan media kartu huruf. Sehingga dapat meningkatkan prestas dalam membaca lancar, siswa kelas satu 1.C SD Negeri 9 Ampenan Tahun Pelajaran 2019/2020. Penelitiaan ini menggunakan tahapan-tahapan yang dilakukan Perencanaan, Pembahasan, Observasi dan Refleksi, penelitian ini dilaksanakan dalam dua siklus yaitu siklu I dan siklus II. Deskripsi hasil dari penlitian ini dapat kita lihat dari masing-masing siklus pada silus I nilai 76,296 (56%) sebyak 14 siswa dari jumlah siswa kelas 1.C sebanya 25 siswa. pada siklus II jumlah nilai 89,636 (92%) sebanyak 23 siswa dari jumlah 25 siswa, hanya 2 orang yang tidak tuntas dalam penelitian ini. Dapat disimpulkan bahwa dengan metode SAS menggunakan kartu huruf dapat meningkatkan keterampilan membaca lancar pada kelas 1.C SD Negeri 9 Ampenan Tahun Pelajaran 2019/2020. Dapat juga metode SAS ini digunakan dalam pembelajaran selain Bahasa Indonseia.
Sistema de irrigación automático asistido por robot
Authors: Ríos Ana , Hall Andrew , Contreras Kenji , Von Chong Alejandro , Cáceres Danilo 
Published: September 2021

Las plantas juegan un rol importante en nuestras vidas, trayéndonos bienestar, mejorando la estética del hogar y brindando beneficios como la purificación del aire, por lo que se desea brindarles el cuidado apropiado, especialmente en el riego continuo y adecuado; tarea que se dificulta de acuerdo con la cantidad de plantas que se poseen. Con el objetivo de facilitar esta tarea, se propone la creación de un sistema de irrigación automático, que tome mediciones de humedad en la tierra de las plantas de un jardín o huerto, establezca la necesidad de riego y realice esta tarea. El desarrollo del prototipo se divide en los sistemas que lo incorporan, como el sistema de medición, el sistema de riego y sistema de detección de plantas. El resultado es un sistema asistido por un robot que se traslada a lo largo de un jardín tomando mediciones en cada planta y tomando la decisión de regarla o no, activando remotamente un sistema de riego que irriga a cada planta según su necesidad, basado en las lecturas tomadas por el robot. El sistema desarrollado brinda una solución autónoma a un problema presente en la vida de muchas personas, y una herramienta útil en los cultivos para la venta, además de que promueve la sostenibilidad ya que permite hacer uso eficiente del agua para suplir a las plantas la cantidad necesaria para mantener su salud y realizar sus funciones.
Multimicronutrient supplements in nutrition of pregnant women: critical analysis of research results
Authors: Kodentsova V. M. , Risnik D. V. 
Published: September 2021

The purpose of the review is to analyze the results of the use of vitamin-mineral supplements (MMS) during pregnancy using the databases of the RSCI, CyberLeninka, pubMed. The detection of micronutrient deficiency in a significant part of pregnant women requires its unconditional correction by taking vitamin-mineral supplements. In recent years, the emphasis has shifted to studying the effect of MMS intake on the course and outcomes of pregnancy. The effects described in the literature should be treated critically. Most of the studies are based only on a retrospective survey of pregnant women (according to the ‘yes' or ‘no' principle), their supply of micronutrients is not monitored; no causal relationship is established. There is no objective monitoring of the MMS intake. Uncertainties include the composition and doses of micronutrients in the MMS used, the lack of data on drug intake, the assumption that all MMS are equivalent in composition and micronutrient content, and the grouping of women taking MMS with different composition into one group. In addition, the use of incorrect indicators in assessing the physical growth of children occurs. The positive effect of additional intake of MMS is manifested only if initially there was a deficiency of micronutrients.Conclusions. The intake of MMS during pregnancy improves the supply of vitamins for those women in whose diet there is a lack of them. This prophylaxis reduces the risk of adverse pregnancy outcomes due to vitamin deficiencies.
A Reference Database of Standardised Continuous Lumbar Intervertebral Motion Analysis for Conducting Patient-Specific Comparisons
Authors: Breen Alexander , De Carvalho Diana , Funabashi Martha , Kawchuk Greg , Pagé Isabelle , Wong Arnold Y. L. , Breen Alan 
Published: September 2021

Lumbar instability has long been thought of as the failure of lumbar vertebrae to maintain their normal patterns of displacement. However, it is unknown what these patterns consist of. Research using quantitative fluoroscopy (QF) has shown that continuous lumbar intervertebral patterns of rotational displacement can be reliably measured during standing flexion and return motion using standardised protocols and can be used to assess patients with suspected lumbar spine motion disorders. However, normative values are needed to make individualised comparisons. One hundred and thirty-one healthy asymptomatic participants were recruited and performed guided flexion and return motion by following the rotating arm of an upright motion frame. Fluoroscopic image acquisition at 15fps was performed and individual intervertebral levels from L2-3 to L5-S1 were tracked and analysed during separate outward flexion and return phases. Results were presented as proportional intervertebral motion representing these phases using continuous means and 95%CIs, followed by verification of the differences between levels using Statistical Parametric Mapping (SPM). A secondary analysis of 8 control participants matched to 8 patients with chronic, non-specific low back pain (CNSLBP) was performed for comparison. One hundred and twenty-seven asymptomatic participants’ data were analysed. Their ages ranged from 18 to 70 years (mean 38.6) with mean body mass index 23.8 kg/m2 48.8% were female. Both the flexion and return phases for each level evidenced continuous change in mean proportional motion share, with narrow confidence intervals, highly significant differences and discrete motion paths between levels as confirmed by SPM. Patients in the secondary analysis evidenced significantly less L5-S1 motion than controls (p &lt; 0.05). A reference database of spinal displacement patterns during lumbar (L2-S1) intersegmental flexion and return motion using a standardised motion protocol using fluoroscopy is presented. Spinal displacement patterns in asymptomatic individuals were found to be distinctive and consistent for each intervertebral level, and to continuously change during bending and return. This database may be used to allow continuous intervertebral kinematics to drive dynamic models of joint and muscular forces as well as reference values against which to make patient-specific comparisons in suspected cases of lumbar spine motion disorders.
Serum Uric Acid and Kidney Disease Measures Independently Predict Cardiovascular and Total Mortality: The Uric Acid Right for Heart Health (URRAH) Project
Authors: Russo Elisa , Viazzi Francesca , Pontremoli Roberto , Barbagallo Carlo M. , Bombelli Michele , Casiglia Edoardo , Cicero Arrigo F. G. , Cirillo Massimo , Cirillo Pietro , Desideri Giovambattista , D'Elia Lanfranco , Dell'Oro Raffaella , Ferri Claudio , Galletti Ferruccio , Gesualdo Loreto , Giannattasio Cristina , Iaccarino Guido , Leoncini Giovanna , Mallamaci Francesca , Maloberti Alessandro , Masi Stefano , Mengozzi Alessandro , Mazza Alberto , Muiesan Maria L. , Nazzaro Pietro , Palatini Paolo , Parati Gianfranco , Rattazzi Marcello , Rivasi Giulia , Salvetti Massimo , Tikhonoff Valérie , Tocci Giuliano , Quarti Trevano Fosca A. L. , Ungar Andrea , Verdecchia Paolo , Virdis Agostino , Volpe Massimo , Grassi Guido , Borghi Claudio 
Published: September 2021

Background: Serum uric acid predicts the onset and progression of kidney disease, and the occurrence of cardiovascular and all-cause mortality. Nevertheless, it is unclear which is the appropriate definition of hyperuricemia in presence of chronic kidney disease (CKD). Our goal was to study the independent impact of uric acid and CKD on mortality.Methods: We retrospectively investigated 21,963 patients from the URRAH study database. Hyperuricemia was defined on the basis of outcome specific cut-offs separately identified by ROC curves according to eGFR strata. The primary endpoints were cardiovascular and all-cause mortality.Results: After a mean follow-up of 9.8 year, there were 1,582 (7.20%) cardiovascular events and 3,130 (14.25%) deaths for all causes. The incidence of cardiovascular and all-cause mortality increased in parallel with reduction of eGFR strata and with progressively higher uric acid quartiles. During 215,618 person-years of follow-up, the incidence rate for cardiovascular mortality, stratified based on eGFR (&gt;90, between 60 and 90 and &lt;60 ml/min) was significantly higher in patients with hyperuricemia and albuminuria (3.8, 22.1 and 19.1, respectively) as compared to those with only one risk factor or none (0.4, 2.8 and 3.1, respectively). Serum uric acid and eGFR significantly interact in determining cardiovascular and all-cause mortality. For each SUA increase of 1 mg/dl the risk for mortality increased by 10% even after adjustment for potential confounding factors included eGFR and the presence of albuminuria.Conclusions: hyperuricemia is a risk factor for cardiovascular and all-cause mortality additively to eGFR strata and albuminuria, in patients at cardiovascular risk.
A Comparison Between Two Definitions of Contrast-Associated Acute Kidney Injury for Long-Term Mortality in Elderly and Non-elderly Patients After Elective Percutaneous Coronary Intervention
Authors: He Haoming , You Zhebin , Lin Xueqin , He Chen , Zhang Sicheng , Luo Manqing , Lin Maoqing , Zhang Liwei , Lin Kaiyang , Guo Yansong 
Published: September 2021

Background: Contrast-associated acute kidney injury (CA-AKI) is responsible for a substantial proportion of the observed mortality that occurs after percutaneous coronary intervention (PCI), particularly in elderly patients. However, there has been significant and debate over whether the optimal definition of CA-AKI persists over prolonged periods due to variations in the prevalence and effects on prognosis. In this study, we aimed to identify whether different definitions of CA-AKI exert differential impacts on long-term mortality when compared between elderly and non-elderly patients receiving elective PCI.Methods: We prospectively investigated 5,587 consenting patients undergoing elective PCI between January 2012 and December 2018. We considered two classical definitions of CA-AKI from the European Society of Urogenital Radiology (ESUR) and the Acute Kidney Injury Network (AKIN). Multivariable Cox regression analysis was used to investigate the association between CA-AKI and long-term mortality. We also performed interaction and stratified analyses according to age (≤75 or &gt;75 years).Results: The incidence of CA-AKI according to the ESUR and AKIN definitions was 18.7 and 6.1%, respectively. After a median follow-up of 2.1 years, multivariable Cox regression analysis indicated that CA-AKI according to the AKIN definition was a risk factor for long-term mortality in the overall population [hazard ratio (HR) = 2.20; 95% confidential interval (CI): 1.51–3.22; p &lt; 0.001]; however, this was not the case for the ESUR definition (HR = 1.27; 95% CI: 0.92–1.76; p = 0.153). Further interaction analysis identified a significant interaction between age and the ESUR definition (p = 0.040). Stratified analyses also found an association between the ESUR definition and long-term mortality in patients &gt;75 years of age (p = 0.011), but not in patients ≤75 years of age (p = 0.657).Conclusion: As a stringent definition of CA-AKI, the AKIN definition was significantly associated with long-term mortality in both non-elderly and elderly patients. However, in elderly patients, the more lenient definition provided by the ESUR was also significantly correlated with long-term mortality, which could sensitively identify high-risk elderly patients and may provide a better alternative.
Diagnosis of Cardiac Involvement in Amyloid A Amyloidosis by Cardiovascular Magnetic Resonance Imaging
Authors: Chamling Bishwas , Drakos Stefanos , Bietenbeck Michael , Klingel Karin , Meier Claudia , Yilmaz Ali 
Published: September 2021

Background: Diagnosis of cardiac involvement in amyloid A (AA) amyloidosis is challenging since AA amyloidosis is a rare disease and cardiac involvement even less frequent. The diagnostic yield of currently available non-invasive imaging methods is not well-studied and rather limited, and invasive endomyocardial biopsy (EMB) is rarely performed due to the potential risk of this procedure. Cardiovascular magnetic resonance (CMR)-based myocardial tissue characterization by late-gadolinium-enhancement (LGE) imaging and novel-mapping approaches may increase the diagnostic yield in AA amyloidosis.Methods: Two patients with AA amyloidosis in whom cardiac involvement was suspected based on CMR findings and subsequently proven by biopsy work-up are presented. CMR studies were performed on a 1.5-T system and comprised a cine steady-state free precession pulse sequence for ventricular function and a late-gadolinium-enhancement (LGE) sequence for detection of myocardial pathology. Moreover, a modified Look-Locker inversion recovery (MOLLI) T1-mapping sequence was applied in basal, mid and apical short-axes prior to contrast agent administration and ~20 min thereafter to determine native T1 and ECV values.Results: Both patients showed slightly dilated left ventricles (LV) with mild to moderate LV hypertrophy and preserved systolic function. Only a very subtle pattern of LGE was observed in both patients with AA amyloidosis. However, markedly elevated native T1 (max. 1,108 and 1,112 ms, respectively) and extracellular volume fraction (ECV) values (max. 39 and 48%, respectively) were measured in the myocardium suggesting the presence of cardiac involvement - with subsequent EMB-based proof of AA amyloidosis.Conclusion: We recommend a multi-parametric CMR approach in patients with AA amyloidosis comprising both LGE-based contrast-imaging and T1-mapping-based ECV measurement of the myocardium for non-invasive work-up of suspected cardiac involvement. The respective CMR findings may be used as gatekeeper for additional invasive procedures (such as EMB) and as a non-invasive monitoring tool regarding assessment and modification of ongoing treatments.
Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires
Authors: Petersen Brian M. , Ulmer Sophia A. , Rhodes Emily R. , Gutierrez-Gonzalez Matias F. , Dekosky Brandon J. , Sprenger Kayla G. , Whitehead Timothy A. 
Published: September 2021

Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mAb development. Here, we present position-specific scoring matrices (PSSMs) for antibody framework mutations developed using baseline human antibody repertoire sequences. Our analysis shows that human antibody repertoire-based PSSMs are consistent across individuals and demonstrate high correlations between related germlines. We show that mutations in existing therapeutic antibodies can be accurately predicted solely from baseline human antibody sequence data. We find that mAbs developed using humanized mice had more human-like FR mutations than mAbs originally developed by hybridoma technology. A quantitative assessment of entire framework regions of therapeutic antibodies revealed that there may be potential for improving the properties of existing therapeutic antibodies by incorporating additional mutations of high frequency in baseline human antibody repertoires. In addition, high frequency mutations in baseline human antibody repertoires were predicted in silico to reduce immunogenicity in therapeutic mAbs due to the removal of T cell epitopes. Several therapeutic mAbs were identified to have common, universally high-scoring framework mutations, and molecular dynamics simulations revealed the mechanistic basis for the evolutionary selection of these mutations. Our results suggest that baseline human antibody repertoires may be useful as predictive tools to guide mAb development in the future.
Safety and Efficacy of the Rechallenge of Immune Checkpoint Inhibitors After Immune-Related Adverse Events in Patients With Cancer: A Systemic Review and Meta-Analysis
Authors: Zhao Qing , Zhang Jianwei , Xu Lingyi , Yang Huaxia , Liang Naixin , Zhang Li , Zhang Fengchun , Zhang Xuan 
Published: September 2021

IntroductionLittle evidence exists on the safety and efficacy of the rechallenge of immune checkpoint inhibitors (ICIs) after immune-related adverse events (irAEs) in patients with cancer.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane for articles on ICI rechallenge after irAEs for systemic review and meta-analysis. The outcomes included the incidence and associated factors for safety and objective response rate (ORR) and disease control rate (DCR) for efficacy.ResultsA total of 789 ICI rechallenge cases from 18 cohort studies, 5 case series studies, and 54 case reports were included. The pooled incidence of all-grade and high-grade irAEs after rechallenge in patients with cancer was 34.2% and 11.7%, respectively. Compared with initial ICI treatment, rechallenge showed a higher incidence for all-grade irAEs (OR, 3.81; 95% CI, 2.15–6.74; p &lt; 0.0001), but similar incidence for high-grade irAEs (p &gt; 0.05). Types of initial irAEs (pneumonitis and global irAEs) and cancer (non-small cell lung cancer and multiple cancer) recapitulated these findings. Gastrointestinal irAEs and time interval between initial irAEs and ICI rechallenge were associated with higher recurrence of high-grade irAEs (p &lt; 0.05), whereas initial anti-PD-1/PD-L1 antibodies were associated with a lower recurrence (p &lt; 0.05). Anti-PD-1/PD-L1 antibodies rechallenge was associated with a lower all-grade irAE recurrence (p &lt; 0.05). The pooled ORR and DCR after rechallenge were 43.1% and 71.9%, respectively, showing no significant difference compared with initial ICI treatment (p &gt; 0.05).ConclusionsICI rechallenge after irAEs showed lower safety and similar efficacy outcomes compared with initial ICI treatment.Systematic Review RegistrationPROSPERO, identifier CRD42020191405.
Plant-Morphing Strategies and Plant-Inspired Soft Actuators Fabricated by Biomimetic Four-Dimensional Printing: A Review
Authors: Ren Luquan , Li Bingqian , Wang Kunyang , Zhou Xueli , Song Zhengyi , Ren Lei , Liu Qingping 
Published: September 2021

Graphical AbstractThe plant-morphing strategies, manufacturing methods, materials, stimuli and applications of biological and bioinspired material.
Recharging Difficulty With Pulse Generator After Deep Brain Stimulation: A Case Series of Five Patients
Authors: Li Hongyang , Su Daoqing , Lai Yijie , Xu Xinmeng , Zhang Chencheng , Sun Bomin , Li Dianyou , Pan Yixin 
Published: September 2021

Background: Deep brain stimulation (DBS) is a well-established treatment for a variety of movement disorders. Rechargeable cell technology was introduced to pulse generator more than 10 years ago and brought great benefits to patients. However, with the widespread use of rechargeable implanted pulse generators (r-IPGs), a new hardware complication, when charging the r-IPG has been difficult, was encountered.Objective: The aims of this study were to report five cases confronted with r-IPG charging difficulty postoperatively and to explore the predisposing factors and treatment strategies for this rare complication.Methods: We retrospectively reviewed our DBS patient database for those who were implanted with r-IPGs. From 2012, we identified a total of 1,226 patients, with five of them experiencing charging difficulties after surgery. Detailed patient profiles and clinical procedures were scrutinized and reviewed.Results: All the charging problems were resolved by reoperation. Cases 1 and 2 required their r-IPGs to be anchored to the muscle and fascia. Cases 3 and 4 had their r-IPGs inserted in the wrong orientation at the initial surgery, which was resolved by turning around the r-IPGs at the revision surgery. Case 5, in which we propose that the thick subcutaneous fat layer blocked the connection between the r-IPG and the recharger, required a second operation to reposition the r-IPG in a shallow layer underneath the skin. For all cases, the charging problems were resolved without reoccurrences to date.Conclusion: Our case series indicates a novel hardware complication of DBS surgery, which had been rarely reported before. In this preliminary study, we describe several underlying causes of this complication and treatment methods.