bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Postsurgical Outcomes with Prepectoral Breast Reconstruction: A Literature Review and Meta-analysis Update
Authors: Chatterjee Abhishek , Nahabedian Maurice Y. , Gabriel Allen , Sporck Michael , Parekh Mousam , Macarios David , Hammer Jason , Sigalove Steven 
Published: October 2021

Background:
Prepectoral implant-based breast reconstruction is an alternative to subpectoral/dual-plane reconstruction.

Methods:
This study examined outcomes of prepectoral reconstruction using a meta-analysis of data pooled with data from our previous review. Thirty studies were included.

Results:
Explantation, seroma, and infection were the most common complications with no animation deformity reported. Significantly lower odds of infection were observed with prepectoral compared with dual-plane reconstruction.

Conclusions:
Current literature suggests that prepectoral reconstruction may be associated with lower rates of postsurgical infections.
Significant Prognostic Factors Influencing the Survival Difference of Oral Tongue Squamous Cell Carcinoma
Authors: Boonpoapichart Sarinya , Punyavong Pattama , Jenwitheesuk Kamonwan , Surakunprapha Palakorn , Winaikosol Kengkart 
Published: October 2021

Background:
Oral tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Overall survival varies across many countries, and poor prognosis is prevalent in developing countries, including Thailand. Our study aimed to identify prognostic factors that affected survival for oral tongue cancer in Thailand.

Methods:
We performed a retrospective study of 183 patients diagnosed with oral tongue squamous cell carcinoma between January 2012 and December 2016 and who underwent multidisciplinary treatment. The disease stage was classified by tumor-nodes-metastasis (TNM) staging system. The survival outcome was calculated and represented in median survival time. Univariate and multivariate Cox proportional hazards models were used to identify factors that impacted survival outcomes.

Results:
A clear margin was achieved in 88.8% of the 125 operated patients. Radiotherapy was given to 115 patients (62.84%). The survival shown in Kaplan-Meier curves was significantly lower according to advanced TNM stage, poor histologic grade, nonsurgical treatment, and patients treated with radical neck dissection. Radiotherapy was a good prognostic factor [hazard ratio (HR) 0.25, P = 0.022]. Poor prognostic factors were body mass index less than 18.5 kg per m2 (HR 3.03), vertical tumor dimension 20 mm or more (HR 5.84), non-well-differentiated grade tumor (HR 3.09), and operated cases with radical neck dissection (HR 4.29).

Conclusions:
Surgical treatment can improve the survival outcome, whereas advanced stage and poor histological grading can worsen the overall survival. For oral tongue squamous cell carcinoma, radiotherapy was a good prognostic factor. On the contrary, a tumor with large vertical size, closed surgical margin, poor histologic grade, and radical neck dissection in the operated group were poor prognostic factors.
Health Conditions Among Special Operations Forces Versus Conventional Military Service Members: A VA TBI Model Systems Study
Authors: Garcia Amanda , Kretzmer Tracy S. , Dams-O'Connor Kristen , Miles Shannon R. , Bajor Laura , Tang Xinyu , Belanger Heather G. , Merritt Bryan P. , Eapen Blessen , McKenzie-Hartman Tamara , Silva Marc A. 
Published: October 2021

Objective:
To examine traumatic brain injury (TBI) characteristics and comorbid medical profiles of Special Operations Forces (SOF) Active Duty Service Member/Veterans (ADSM/Vs) and contrast them with conventional military personnel.

Setting:
The 5 Veterans Affairs (VA) Polytrauma Rehabilitation Centers.

Participants:
A subset of participants in the VA TBI Model Systems multicenter longitudinal study with known SOF status. These included 157 participants who identified as SOF personnel (average age = 41.8 years; 96% male, 81% active duty), and 365 who identified as Conventional Forces personnel (average age = 37.4 years; 92% male, 30% active duty).

Design:
Retrospective analysis of prospective cohort, cross-sectional.

Main Measures:
The Health Comorbidities Interview.

Results:
SOF personnel were more likely to have deployed to a combat zone, had more years of active duty service, and were more likely active duty at time of TBI. SOF personnel were more likely to have had mild TBI (vs moderate/severe) and their TBI caused by violent mechanism. SOF personnel had a higher number of comorbidities, with more diagnoses of chronic pain, osteoarthritis, hyperlipidemia, hip fractures, and obstructive sleep apnea.

Conclusion:
SOF personnel are at a higher risk for multimorbidity after TBI. Current rehabilitation practices should incorporate early screening and treatment of common conditions in this population, while future practices may benefit from a focus on prevention.
Manufacturing defect of a Zeiss multifocal intraocular lens
Authors: McKee Hamish D. , Jhanji Vishal 
Published: October 2021

Introduction:
A case of cataract surgery with multifocal intraocular lens (IOL) insertion where the lens was found to have a manufacturing defect with decentred diffractive rings on the optic is reported.

Patient and clinical findings:
A toric AT LISA tri (Carl Zeiss Meditec AG) IOL was implanted into the capsular bag in the right eye of a 58-year-old woman. After implantation it was noted that the diffractive rings were off center and not aligned with the toric lens markings.

Diagnosis, intervention, and outcomes:
The IOL was explanted and another IOL of the same type and power was inserted.

Conclusions:
This case shows that centration defects of multifocal IOLs exist. Surgeons need to be aware of this and make sure they have instruments on hand for explantation and backup IOLs for each case.
Classification and citation analysis of the 100 top-cited articles on adult spinal deformity since 2011: A bibliometric analysis
Authors: Liu Po-Chun , Lu Yi , Lin Hsi-Hsien , Yao Yu-Cheng , Wang Shih-Tien , Chang Ming-Chau , Chien Tsair-Wei , Chou Po-Hsin 
Published: October 2021

Background:
Studies of the 100 most-cited articles are reported for many subjects. However, none has analyzed the article characteristics associated with high citation frequency. This study aims to (1) graphically depict characteristics of the 100 top-cited articles addressing adult spinal deformity (ASD), (2) diagram the association between articles according to subject and major topic medical subject headings (MeSHs), and (3) investigate whether major topic MeSH correlates with article citation frequency.

Methods:
The 100 top-cited ASD publications since 2011 were retrieved using a PubMed Central search on May 6, 2020. Using titles and abstracts, eight subject categories were identified: surgery, conservative treatment, normal values in spinopelvic alignment, review, cervical alignment, classification, compensatory mechanism, and spine-hip relationship. Sankey diagrams were used to organize the information. Network analysis was performed according to article subject and major topic MeSHs. Pearson’s r was used to determine whether the weighted number of citations correlates with major topic MeSHs and the number of citations.

Results:
The average number of citations per article was 34.8 (range, 19–156). The most represented country was USA (n = 51). The most productive and highly cited journal was Spine (Phila Pa 1976) (n = 34; average, 38.2 citations per article). The most frequent subject categories and major topic MeSHs were “surgery” (n = 53) and “scoliosis” (weighted count, 9.8), while articles with the subject “compensatory” had the highest average number of citations (64.7). The most highly cited article, by Dr. F. Schwab in 2012, had 156 citations. Network analysis revealed the relationships between these articles according to major topic MeSHs. The weighted number of citations according to major topic MeSHs correlated significantly with article citation frequency (Pearson’s r, 0.57; p < 0.001).

Conclusion:
Multiple characteristics of the 100 top-cited ASD articles are presented in diagrams to guide evidence-based clinical decision-making in ASD.
Does rotation during catheter withdrawal in embryo transfer increase pregnancy rates?
Authors: Gurbuz Ali Sami , Yildiz Yunus 
Published: October 2021

Background:
The aim of this study was to determine whether there is a difference in pregnancy rates between groups that we removed directly and removed by rotating the embryo transfer catheter 360°.

Methods:
The study group consisted of 552 patients who were withdrawn by 360° rotation and 797 patients who were withdrawn without catheter rotation. All patients underwent one or two fresh ETs on day 3 or 5. Groups were compared in terms of cycle characteristics and clinical pregnancy rates.

Results:
There were no significant differences in demographic and clinical characteristics of both groups, such as age, body mass index (BMI), duration of infertility, causes of infertility, and basal hormone levels. Clinicals pregnancy rate, in the study group, 48% (265/552) and in the control group, 50.8% (405/797) were similar in both groups. When the implantation rate and miscarriage rate were examined, both groups were found to be similar.

Conclusion:
It was found that 360° rotation while pulling catheter during embryo transfer had no effect on pregnancy and clinical pregnancy.
Total knee replacement for patients with severe hemophilic arthropathy in Taiwan: A nationwide population-based retrospective study
Authors: Chen Cheng-Fong , Yu Yuan-Bin , Tsai Shang-Wen , Chiu Jan-Wei , Hsiao Liang-Tsai , Gau Jyh-Pyng , Hsu Hui-Chi 
Published: October 2021

Background:
Total knee replacement (TKR) surgery is a treatment option for advanced hemophilic arthropathy. Due to its rarity and complexity, previous reports could only demonstrate the results of single-site studies including few cases. This population-based study aimed to investigate the major epidemiological characteristics, mean consumption of coagulation factors, length of hospital stays, complications, and failure rate of primary TKR for severe hemophilia patients in Taiwan.

Methods:
A cohort of 996 hemophilia patients registered between 1995 and 2011 was included, and 103 primary TKRs were performed on 75 patients. Unilateral TKR was performed on 47 patients and bilateral TKRs on the remaining 28 patients, including 12 simultaneous and 16 staged surgeries. The mean age at surgery was 32.3 years (range, 17.3–55.7), and the mean follow-up duration was 77.9 months (range, 2.3–176.8).

Results:
Failure was noted in 8 patients (8.5%) at mean 32.8 months (range, 2.3–95) after surgery. Four patients revealed aseptic loosening, whereas infection in 4. The 10-year prosthesis survivorship was 88.6%. For patients receiving unilateral TKR, the mean length of hospital stay was 15 days (range, 7–32). The mean cost of factor supplement was United States Dollar (USD) 43 543 with a mean 4-unit packed red blood cells transfusion (range, 0–38). The total admission cost was USD 48 326 (range, USD 4165–262 619).

Conclusion:
The prevalence of TKA for hemophilia patients was 7.5% in Taiwan. The mean hospital stay was 14 days, and the 10-year prosthesis survivorship was 88.6%. The mean daily factor usage was decreased from 235.7 units preoperatively to 202.1 units postoperatively. In comparison with the staged-bilateral TKRs, the simultaneous procedures significantly reduced the mean total cost from USD 101 923 to USD 61 587 (p = 0.023). Therefore, in terms of cost-effectiveness, bilateral simultaneous TKR is more preferable than staged procedures.
Group-based trajectory analysis of postoperative pain in epidural analgesia for video-assisted thoracoscopic surgery and risk factors of rebound pain
Authors: Chang Wen-Kuei , Li Yi-Shiuan , Wu Hsiang-Ling , Tai Ying-Hsuan , Lin Shih-Pin , Chang Kuang-Yi 
Published: October 2021

Background:
The current study aimed to investigate the patterns of postoperative pain trajectories over time and their associated risk factors in patients receiving video-assisted thoracoscopic surgery (VATS) and epidural analgesia (EA) for non–small cell lung cancer (NSCLC).

Methods:
This retrospective study was conducted at a tertiary medical center and included patients undergoing VATS for stage I NSCLC between 2011 and 2015. Maximal pain intensity was recorded daily during the first postoperative week. Group-based trajectory analysis was performed to categorize variations in pain scores over time. Associations between pain trajectory classification and amount of EA administered and length of hospital stay (LOS) after surgery were also evaluated.

Results:
A total of 635 patients with 4647 pain scores were included in the analysis, and 2 postoperative pain trajectory groups were identified: group 1, mild pain trajectory (78%); and group 2, rebound pain trajectory (22%). Risk factors for rebound pain trajectory were a surgical time longer than 3 hours (odds ratio [OR], 1.97; 95% CI, 1.27–3.07), female sex (OR, 1.62; 95% CI, 1.04–2.53), and higher pain score on postoperative day 0 (OR, 1.21; 95% CI, 1.08–1.36; linear effect). Although group 2 had a longer LOS (p < 0.001), they did not receive more EA than group 1 (p = 0.805).

Conclusion:
Surgical time, sex, and pain intensity after surgery were major determinants of rebound pain trajectory, and more aggressive pain control strategies should be considered in high-risk patients.
Clinical characteristics and outcomes of drug-induced liver injury in Taiwan: With emphasis on the impact of chronic hepatitis B infection
Authors: Huang Yi-Shin , Tseng Shao-Yu , Chen Wen-Wen , Chang Ting-Tsung , Peng Cheng-Yuan , Lo Gin-Ho , Hsu Chao-Wei , Hu Chi-Tan , Huang Yi-Hsiang 
Published: October 2021

Background:
Whether hepatitis B virus (HBV) infection can affect the outcomes of drug-induced liver injury (DILI) is controversial. This study aimed to evaluate the characteristics and outcomes of DILI in Taiwan, with an emphasis on the impact of HBV infection.

Methods:
We prospectively recruited patients with DILI from multiple centers in Taiwan from 2010 to 2018.

Results:
A total of 1,014 patients were enrolled. The leading culprit drug category was antimicrobials (481, 47.4%), followed by nonsteroidal anti-inflammatory drugs, anticonvulsants, and statins. Among the antimicrobials, antituberculosis agents were most likely to induce liver injury (257, 25.3%), followed by antibacterial, antifungal, and antiviral agents. The liver-related mortality rate was 8.2% (83/1,014). The patients who died had higher rates of hepatocellular-type liver injury, elevated liver biochemical tests, preexisting liver cirrhosis, jaundice, chronic HBV infection, and antituberculosis drug-induced liver injury (ATDILI) than the survivors. A total of 131 patients (12.9%) with DILI were HBV carriers, of whom 23 (17.6%) died of hepatic failure. The rate of HBV-DNA > 2000 IU/mL was higher in the patients who died (47.8% vs. 26.9%, p = 0.047) than in the survivors. After adjusting for possible risk factors, active HBV infection with HBV-DNA > 2000 IU/mL was the most significant risk factor for liver-related mortality (adjusted HR, 4.40, 95% CI, 2.31%-8.38%, p < 0.001). The other independent risk factors for mortality were ATDILI and albumin-bilirubin (ALBI) score (adjusted HR, 1.25 and 4.09, respectively, p < 0.003).

Conclusion:
Antituberculosis agents were the leading cause of DILI in Taiwanese, and they were associated with poorer outcomes than other drug categories. Active HBV infection, ATDILI and ALBI score were independent risk factors for fatal DILI. Close monitoring of liver tests and timely antiviral therapy should be implemented in HBV carriers during the administration of high-risk drugs, such as antituberculosis agents.
Discriminant Validity of the Parent-Proxy Preschool HEAR-QL
Authors: Zhang Amy L. , Jeffe Donna B. , Lieu Judith E. C. 
Published: October 2021

Objective:
The parent-proxy Preschool HEAR-QL (Hearing Environments And Reflections on Quality of Life) is a quality of life (QOL) measure for 2 to 6-year-old children with hearing loss (HL). We compared Preschool HEAR-QL scores for children with HL and children with normal hearing (NH) to examine the measure's discriminant validity.

Study Design:
Cross-sectional study.

Setting:
Three tertiary care pediatric otolaryngology clinics.

Patients:
Two hundred forty-eight parents of children 2 to 6 years old with NH or HL participated.

Interventions:
None.

Main Outcome Measure:
The Preschool HEAR-QL has five domains: Behavior and Attention, Hearing Environments, New Social Situations, Social Interactions, and Communications. Scores range from 0 to 100; higher scores indicate higher QOL. Scores for children with NH and with HL were compared using analysis of variance (ANOVA) and area under the receiver operating characteristic (AUROC) curves.

Results:
Total HEAR-QL mean (SD) scores were higher for children with NH compared to children with HL (75.7 [10.5] vs. 67.5 [15.5], p < 0.001). Scores were not significantly different between children with unilateral and bilateral HL. Children 2 to 4 years old received lower Communications-domain scores than children 4 to 6 years old across all children (63.7 [25.4] vs. 74.1 [24.3], p = 0.01) and within the HL cohort (61.3 [25.1] vs. 72.6 [25.3]; p = 0.009). The Hearing Environments domain displayed excellent discrimination (AUROC = 0.858); other domains showed little to no discrimination.

Conclusions:
The Hearing Environments-domain of the Preschool HEAR-QL differentiated between children with and without HL. Children with NH had higher scores than children with HL on both Total HEAR-QL and Hearing Environment-domain scores.
Relationship Between Clinical Features and the Arc and Length of Dehiscence in SCDS: A Single Center Review of 42 Cases
Authors: Darr Adnan , Thomas Charlotte , Rainsbury James , Banga Rupan , Irving Richard , Chavda Swarupsinh 
Published: October 2021

Introduction:
Superior canal dehiscence syndrome (SCDS) is a rare disorder characterized by an array of audiovestibular symptoms due to a dehiscence of bone overlying the superior semicircular canal (SSC). In the presence of debilitating symptoms, surgical management, to plug or resurface the SCC is performed. Although computed tomography (CT) may overestimate the size or presence of a dehiscence due to a partial volume effect, it remains an invaluable diagnostic tool.

Objectives:
To assess for correlation between the arc and length of dehiscence and clinical symptomology.

Method:
A single-center, single-operator retrospective analysis of 42 patients who underwent trans mastoid plugging of SCC with confirmed radiological dehiscence of their SSC between January 2008 and July 2019 was undertaken. Patients were assessed based on seven predefined clinical symptoms. Length and arc of dehiscence's were evaluated by means of high resolution (0.5 mm) CT (HRCT), using multiplanar reconstruction (MPR). Receiver operating characteristics (ROC), and more specifically the area under the ROC curve (AUROC) were used to assess for statistical significance.

Results:
Our results demonstrate overall very little correlation between the arc and size of the dehiscence and symptoms. The only statistically significant correlation we found was between length of dehiscence and the presence of aural fullness.

Conclusion:
SCDS is a debilitating condition with an array of symptoms on presentation. While dehiscence length demonstrated a correlation with aural fullness, no other symptomology in patients with radiologically evident SCDS demonstrated a statistically significant correlation either against the length or arc of dehiscence.
Effects of vibegron on ambulatory blood pressure in patients with overactive bladder: results from a double-blind, placebo-controlled trial
Authors: Weber Michael A. , Haag-Molkenteller Cornelia , King Jennifer , Walker Ann , Mudd Paul N. , White William B. 
Published: October 2021

Objectives
To characterize the blood pressure (BP) profile of the new β3-adrenergic receptor agonist, vibegron, in patients with overactive bladder.

Methods
Patients were randomized to once-daily vibegron 75 mg or placebo for 28 days and underwent ambulatory BP monitoring. The primary endpoint was change from baseline (CFB) to day 28 in mean daytime ambulatory systolic BP (SBP). Secondary endpoints were CFB in mean 24-h SBP and in mean daytime and mean 24-h ambulatory diastolic BP (DBP) and heart rate (HR). Safety was assessed through adverse event reporting.

Results
Of 214 patients randomized, 96 receiving vibegron and 101 receiving placebo had evaluable baseline and day 28 measurements. Overall, 39.6 and 30.7% of patients receiving vibegron and placebo, respectively, had preexisting hypertension. The least squares mean difference (LSMD; 90% confidence interval) between vibegron and placebo in CFB in mean daytime SBP was 0.8 (–0.9, 2.5) mmHg. LSMD in CFB in mean daytime DBP and HR was 0.0 mmHg and 0.9 bpm, respectively. No significant differences between treatments were seen in CFB in mean 24-h SBP (LSMD, 0.6 mmHg), DBP (–0.2 mmHg) or HR (1.0 bpm). The most common treatment-emergent adverse event was hypertension, with rates comparable between groups [vibegron: n = 5 (4.7%); placebo: n = 4 (3.7%)]. One patient receiving vibegron took a prohibited medication (phentermine) known to increase BP.

Conclusions
Once-daily vibegron had no statistically significant or clinically relevant effects on BP or HR.
Pediatric Mycosis Fungoides: Retrospective Analysis of a Series With CD8+ Profile and Female Predominance
Authors: Purnak Seda , Mark Lawrence A. 
Published: October 2021

Background:
Mycosis fungoides (MF) in children is a rare disease and there are limited data regarding the behavior of the disease in this age group. We aimed to collect additional data to better understand the clinicopathologic features of MF in children.

Materials and Methods:
This study was a retrospective analysis of pediatric MF patients (diagnosed at age 0 to 18 y).

Results:
Thirteen pediatric patients with MF were identified. Female predominance was observed with a ratio of 1.6:1. Median values for age of onset of skin lesions and age at the time of histologic diagnosis were 5 and 12 years, respectively. All patients had early stage (stage IA to IIA) of MF at the time of diagnosis. Hypopigmented MF comprised 77% of all study patients, followed by classic MF (15%) and pagetoid reticulosis (8%). The lower extremity (especially proximal leg) followed by trunk and upper extremity were most commonly affected sites. Seven of 9 patients who had available immunohistochemistry data showed CD8+ predominance. Five of 8 patients whose follow-up data was available, achieved complete response with narrowband ultraviolet B treatment, while 2 and 1 had near complete response and partial response, respectively.

Conclusions:
Our study demonstrated female sex and CD8+ profile predominance. Hypopigmented MF constituted the majority of cases. We observed good responses with narrowband ultraviolet B treatment.