bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS PENGGUNAAN GOOGLE CLASSROOM TERHADAP KUALITAS PEMBELAJARAN DAN HASIL BELAJAR
Authors: Wardani Kiky Rizky nova , Jamalludin Ratno 
Published: June 2021

Pelajaran penjaskes di sekolah banyak menuntut siswa untuk dapat bergerak lebih aktif diluar kelas dibandingkan pembelajaran di dalam kelas. Kondisi global saat ini yaitu dengan adanya pandemic covid 19 menyebabkan pembelajaran di lingkungan sekolah dialihkan kepembelajaran daring, salah satunya dengan memanfaatkan google classroom sebagai media pembelajaran. Adapun Tujuan dari penelitian ini adalah mengetahui efektivitas pengaruh penggunaan aplikasi google classroom dan google form terhadap kualitas pembelajaran dan hasil belajar siswa SMK Negeri 1 Indralaya Selatan kelas X (Sepuluh). Penelitian ini menggunakan metode penelitian kuantitatif deskriptif yang dalam peneltian ini menggunakan analisis regresi linear berganda dan regresi logistic ordinal dengan jumlah populasi berjumlah 360 siswa. Teknik purposive sampling digunakan dalam menentukan sampel penilitian sehingga didapatkan jumlah 60 siswa sebagai sampel. Sedangkan untuk pengumpulan data menggunakan tes objectif, wawancara, kuesioner, Pengamatan dan dokumentasi. Hasil penelitian yang telah dilakukan menyatakan bahwa: (1) terdapat efektivitas pengaruh positif yang sangat signifikan dalam penggunaan google classroom terhadap kualitas pembelajaran siswa pada mata pelajaran penjaskes kelas Xa dan Xb di SMK N 1 Indralaya Selatan dengan nilai t hitung> t tabel (2.357 > 2.045) dan nilai signifikansi 0.025. Artinya penggunaan google classroom dapat meningkatkan kualitas pembelajaran siswa pada mata pelajaran penjaskes kelas X di SMK N1 Indralaya Selatan. (2) terdapat pengaruh positif signifikan penggunaan google classroom terhadap hasil belajar siswa pada mata pelajaran penjaskes kelas X di SMK N1 Indralaya Selatan sebesar e 0.892= 2.44 kali dengan signifikansi 0.016. Artinya penggunaan aplikasi google classroom memiliki pengaruh signifikan sebesar 2.44 terhadap hasil belajar siswa.
Opiniones de los profesores de la UAA acerca de la formación y actualización académica para la docencia
Authors: Saucedo Ventura Karla del Rosario 
Published: June 2021

Este apartado rescata las opiniones de algunos profesores de la Universidad Autónoma de Aguascalientes de diferentes Centros Académicos en relación con la formación y actualización académica para la labor docente.
Entrevista a: Dra. María Elena Siqueiros Delgado
Authors: Saucedo Ventura Karla del Rosario 
Published: June 2021

(KRSV): ¿Cuántos años tiene usted aquí trabajando en la Universidad como docente?
(MESD): Entré a la Universidad Autónoma de Aguascalientes en 1982. Egresé de la carrera de Biología que empezó a dos años de creada la UAA y voy a cumplir como docente 28 años.
Enseñar, prioridad revolucionaria
Authors: Camacho Sandoval Salvador , Hernández Santos Marcelo 
Published: June 2021

Algunos estudios nos han aclarado ciertos aspectos que antes aparecían nublosos. Ahora sabemos que la Revolución tuvo un carácter popular, campesino y nacionalista, tal como lo señaló Tannenbaum y lo retomó y argumentó décadas después con una magnífica investigación el inglés Alan Knight; pero también ahora sabemos que hubo diversos intereses que jugaron un papel muy importante en el rumbo que siguió el movimiento. En primer lugar, destacaría la intervención de los grupos poderosos de exporfiristas que abogaban por un país moderno y democrático.
La cultura de la evaluación
Authors: León Portillo Oswaldo , Mora López Juana , Sotelo Orozco Luz María 
Published: June 2021

Existe un consenso cada vez mayor entre los expertos en educación a nivel internacional, en el sentido de que la mejor alternativa para mejorar el nivel educativo de los jóvenes no es simplemente invertir más dinero en las escuelas, ni aumentar las horas de estudio, ni reducir el número de estudiantes por aula, sino crear una cultura de evaluación que obligue a los estudiantes a superarse cada vez más.
La lectura bajo un enfoque constructivista
Authors: Ruiz Salazar Jazmín Viridiana 
Published: June 2021

A lo largo del tiempo, investigadores y expertos en el área del constructivismo se han aproximado al estudio de la lectura utilizando distintos enfoques. Éstos han sido influidos por diferentes corrientes psicológicas y por las nuevas teorías sobre la forma en que se da el proceso de enseñanza y aprendizaje.
El desarrollo de habilidades informativas o alfabetización informativa
Authors: González Sandoval José Luis 
Published: June 2021

La intención del Departamento de Información Bibliográfica (DIB) de la UAA, en comunión con la alfabetización informativa, es crear en los usuarios, ya sean investigadores o profesores de la institución, habilidades básicas para acceder a la información digital y virtual para encontrar información acorde a su entorno educativo y laboral.
El uso del “Ámbito académico” de la UAA como herramienta facilitadora de la práctica docente
Authors: Romero Reyes Evaristo Javier , Vega Martínez Javier Eduardo 
Published: June 2021

Desde hace un tiempo ha estado presente el tema de las tecnologías de información y comunicación; la información más precisa y más actual se puede poner a disposición de cualquier persona en la superficie del mundo, a menudo en tiempo real, y llegar a las regiones más apartadas (Delors, 1997: 37). La expresión tecnología educativa se ha utilizado con diferentes acepciones, siendo aquella que hace referencia a la incorporación de instrumentos técnicos con el propósito de mejorar el proceso didáctico; se trata de la incorporación de la tecnología aplicada a la educación, que incluye fundamentalmente la informática y los medios audiovisuales (Ander-Egg, 1999: 279).
Plataformas educativas para apoyar la formación docente
Authors: (DEFAA) Departamento de Formación y Actualización Académica 
Published: June 2021

La formación docente es una actividad que requiere de una actualización constante, con el fin de buscar innovar la educación y lograr una mejor calidad en diversas áreas de la misma, como la utilización de diversos recursos didácticos para lograr dicho propósito. Por ello, en Ver y leer, le presentamos algunas opciones que podrán ser de utilidad para mejorar su labor en el aula: Coursera, Índice de Revistas Mexicanas de Divulgación Científica y Tecnológica, Recursos en línea para el alumnado de inglés y The Flipped Classroom.
In vitro antioxidant activity of the methanolic extract of leaves of a hill tract plant Begonia roxburghii
Authors: Akter Taslima , Nawar Afra , Alam Md Nur , Md Rafiquzzaman - 
Published: June 2021

The study was designed to investigate the antioxidant activities of the methanolic extract of leaves of Begonia roxburghii by five different in vitro methods namely Folin-Ciocalteu, total flavonoid content, phosphomolybdenum, total reducing power determination, and DPPH scavenging activity. Phenol content (Gallic acid equivalent) was found as 180.40±0.03 mg/g of the dry sample by the Folin-Ciocalteu method. Flavonoid assay method revealed the content of flavonoids (Quercetin equivalent) as 60.43±0.27 mg/g of the dry sample. Total antioxidant capacity of the extract was observed 243.43±0.11 mg/g ( ascorbic acid equivalent) by phosphomolybdenum method. Free radical scavenging activity (measured by the DPPH test) of the methanolic extract was found 158.36±0.22 μg/mL whereas ascorbic acid, the standard, showed 19.53±0.04 μg/mL. The methanolic extract of Begonia roxburghii leaves exhibited positive and linear dose dependent reducing power activity and its activity was comparable to the standard ascorbic acid for a given dose. Phytochemical screening of the extract showed positive results for alkaloids, carbohydrates, flavonoids, glycosides, saponins, steroids, and tannins, which demonstrate definite pharmacological actions on human body. The extract showed negative results for the steroids.
Jahangirnagar University J. Biol. Sci. 9(1 & 2): 79-89, 2020 (June & December)
Production of enzymatic complex from agro-industrial biomass and its application in combustible ethanol
Authors: Arruda Adam Gonçalves , Evangelista Igor Vieira , Menezes Larissa Soares de , Fischer Janaína , Cardoso Vicelma Luiz , Santos Líbia Diniz , Guidini Carla Zanella 
Published: June 2021

Waste biomass and agro-industrial by-products, for production ethanol, will meet much of the great demand for this product. To reduce costs and optimize production, this study investigated solid-state fermentation (SSF) to obtain crude enzyme complex (CEC) from different agro-industrial biomasses (sugarcane bagasse, corn peel bran, rice straw bran and roasting and ground coffee residue) using cellulolytic fungi. The most promising CEC were evaluated in simultaneous hydrolysis and fermentation (SHF) for ethanol production by Saccharomyces cerevisiae in a culture broth containing sugarcane bagasse treated by steam explosion, and roast and ground coffee residue. In SSF with bioreactor volume of 0.25 L, containing 40 g of the biomass mixture and 40 g of sterile water with resuspended cells (1.0 x108 spores/g of solid medium) and temperature of 30±2 ºC, the strains Trichoderma reesei and Penicilium oxalicum provided the best enzyme activity. The CEC of T. reesei provided a concentration of 7.5 g L-1 of ethanol in a substrate containing treated sugarcane bagasse (60%) and roast and ground coffee residue (40%), under SHF conditions (pH 4.5, 35±2 °C, 48 h). The results obtained in this study show a promising alternative for correct disposal and use of residues and agro-industrial by-products by use in the production of enzymes and lignocellulosic ethanol.
Terapia medicamentosa segura: perspectivas da enfermagem e da farmácia no cuidado de paciente em Unidade de Terapia Intensiva (UTI)
Authors: França Dayane Lins , Castro Tailaine Nascimento de , Nobre Valdjane Nogueira Noleto 
Published: June 2021

Diante do número alarmante de eventos adversos relacionados a medicamentos no âmbito da Unidade de Terapia Intensiva (UTI), ações efetivas no cuidado do paciente são necessárias. Nessa perspectiva, este trabalho tem como objetivo discutir o papel da enfermagem e da farmácia quanto à utilização segura de medicamentos, visando garantir a qualidade da assistência prestada a pacientes críticos. Foi realizada uma revisão integrativa, de caráter exploratório-descritivo com abordagem qualitativa, na qual resultou na seleção de 21 artigos, publicados entre janeiro e abril de 2021, indexados nas principais bases de dados. A partir dos estudos analisados, observou-se que os principais eventos adversos estavam relacionados a erros de prescrição, preparo e administração; ocorrência de interações medicamentosas; incompatibilidades entre drogas e equipamentos. O surgimento desses problemas foi associado à falha de comunicação da equipe multiprofissional, a sobrecarga de trabalho e a falta de conhecimento sobre farmacodinâmica e farmacocinética da droga. Portanto, faz-se necessário a integração e articulação de enfermeiros e farmacêuticos para que a farmacoterapia seja efetiva, segura e assertiva, mediante a complexidade projetada na prática, demandando desses profissionais maior capacitação e treinamento.
Immune Infiltrates of m6A RNA Methylation-Related lncRNAs and Identification of PD-L1 in Patients With Primary Head and Neck Squamous Cell Carcinoma
Authors: Feng Zi-Yi , Gao Hao-Yu , Feng Tian-Da 
Published: June 2021

Background: The purpose of this study was to determine the association between m6A-modified lncRNAs, immune infiltration, and PD-L1 expression in patients with primary head and neck squamous cell carcinoma (HNSCC) and the prognostic value of m6A RNA methylation-related lncRNAs in HNSCC.Methods: We downloaded the RNA-seq transcriptome data and the clinical information for HNSCC from the TCGA databases and used consensus clustering analysis to divide the samples into two groups. To identify a risk signature, least absolute shrinkage and selection operator (LASSO) analyses were conducted. the association between m6A-modified lncRNAs, immune infiltration, and PD-L1 expression were detected by using the R packages. What is more, we used cBioPortal tools to identify genomic alterations and PD-L1 mutations and Gene set enrichment analysis (GSEA) was utilized to predict downstream access of two clusters.Results: Notably, lncRNAs play significant roles in tumorigenesis and development. In total, we identified two subtypes of HNSCC according to consensus clustering of the m6A RNA methylation-related lncRNAs, and the T, grade and age were proven to be related to the subtypes. The Cox regression and LASSO analyses identified a risk signature including GRHL3-AS1, AL121845.4, AC116914.2, AL513190.1. The prognostic value of the risk signature was then proven. The selected gene PD-L1 mutations and the immune infiltration in both groups were further explored.Conclusion: Collectively, our study elucidated the important role of m6A RNA methylation- related lncRNAs in tumor microenvironment of HNSCC. The proposed m6A RNA methylation- related lncRNAs might serve as crucial mediators of tumor microenvironment of HNSCC, representing promising therapeutic targets in improving immunotherapeutic efficacy.
Holocene Lake Evolution and Glacial Fluctuations Indicated by Carbonate Minerals and Their Isotopic Compositions in the Sediments of a Glacial Melt Recharge Lake on the Northwestern Tibetan Plateau
Authors: Li Minghui , Zhu Liping , Wang Junbo , Ju Jianting , Liu Chong , Ma Qingfeng , Xu Teng , Qiao Baojin , Wang Xiaoxiao 
Published: June 2021

Lakes and glaciers are widely distributed on the Tibetan Plateau and are linked via hydrological processes. They are experiencing rapid changes due to global warming, but their relationships during the Holocene are less well known due to limited coupled geological records. Here, we analyzed the δ13C-VPDB and δ18O-VPDB values and ion content of calcite and aragonite in a 407-cm-long sediment core from Guozha Co, a closed basin on the northwestern Tibetan Plateau supplied by glacial meltwater, in order to understand how the lake responded to glacier changes during the Holocene. Our results indicate that the glacial meltwater lowered the lake’s temperature and the δ18Olake water and δ18Oendogenic + authigenic carbonate values and diluted the ion concentrations in the lake water. Three stages of evolution, 8.7–4.0, 4.0–1.5, and 1.5 kyr BP to present, are distinguished based on the decrease in glacial meltwater recharge. Guozha Co has been a closed basin since at least 8.7 kyr BP, and it has changed from a fresh water lake during 8.7–1.5 kyr BP to a brackish lake from 1.5 kyr BP to present due to several climate events. The famous 4.2 kyr BP cold event was identified in the core at 4.0 kyr BP, while warm events occurred at 6.2, 3.9, 2.2, 0.9, and 0.4 kyr BP. Both glaciers and lakes in this area are controlled by climate, but they exhibit opposite changes, that is, glaciers retreat and lakes expand, and vice versa. Our results provide an accurate interpretation of the cold events based on carbonate minerals and carbon–oxygen isotopes in glacial meltwater–recharged lake sediments.
High Genetic Heterogeneity in Chinese Patients With Waardenburg Syndrome Revealed by Next-Generation Sequencing
Authors: Zhang Sen , Xu Hongen , Tian Yongan , Liu Danhua , Hou Xinyue , Zeng Beiping , Chen Bei , Liu Huanfei , Li Ruijun , Li Xiaohua , Zuo Bin , Tang Ryan , Tang Wenxue 
Published: June 2021

ObjectiveThis study aimed to explore the genetic causes of probands who were diagnosed with Waardenburg syndrome (WS) or congenital sensorineural hearing loss.MethodsA detailed physical and audiological examinations were carried out to make an accurate diagnosis of 14 patients from seven unrelated families. We performed whole-exome sequencing in probands to detect the potential genetic causes and further validated them by Sanger sequencing in the probands and their family members.ResultsThe genetic causes for all 14 patients with WS or congenital sensorineural hearing loss were identified. A total of seven heterozygous variants including c.1459C &gt; T, c.123del, and c.959-409_1173+3402del of PAX3 gene (NM_181459.4), c.198_262del and c.529_556del of SOX10 gene (NM_006941.4), and c.731G &gt; A and c.970dup of MITF gene (NM_000248.3) were found for the first time. Of these mutations, we had confirmed two (c.1459C &gt; T and c.970dup) are de novo by Sanger sequencing of variants in the probands and their parents.ConclusionWe revealed a total of seven novel mutations in PAX3, SOX10, and MITF, which underlie the pathogenesis of WS. The clinical and genetic characterization of these families with WS elucidated high heterogeneity in Chinese patients with WS. This study expands the database of PAX3, SOX10, and MITF mutations and improves our understanding of the causes of WS.
A Non-invasive Model for Predicting Liver Inflammation in Chronic Hepatitis B Patients With Normal Serum Alanine Aminotransferase Levels
Authors: Li Xiaoke , Xing Yufeng , Zhou Daqiao , Xiao Huanming , Zhou Zhenhua , Han Zhiyi , Sun Xuehua , Li Shuo , Zhang Ludan , Li Zhiguo , Zhang Peng , Zhang Jiaxin , Zhang Ningyi , Cao Xu , Zao Xiaobin , Du Hongbo , Tong Guangdong , Chi Xiaoling , Gao Yueqiu , Ye Yong'an 
Published: June 2021

Background and Aims: Chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels are at risk of disease progression. Currently, liver biopsy is suggested to identify this population. We aimed to establish a non-invasive diagnostic model to identify patients with significant liver inflammation.Method: A total of 504 CHB patients who had undergone liver biopsy with normal ALT levels were randomized into a training set (n = 310) and a validation set (n = 194). Independent variables were analyzed by stepwise logistic regression analysis. After the predictive model for diagnosing significant inflammation (Scheuer's system, G ≥ 2) was established, a nomogram was generated. Discrimination and calibration aspects of the model were measured using the area under the receiver operating characteristic curve (AUC) and assessment of a calibration curve. Clinical significance was evaluated by decision curve analysis (DCA).Result: The model was composed of 4 variables: aspartate aminotransferase (AST) levels, γ-glutamyl transpeptidase (GGT) levels, hepatitis B surface antigen (HBsAg) levels, and platelet (PLT) counts. Good discrimination and calibration of the model were observed in the training and validation sets (AUC = 0.87 and 0.86, respectively). The best cutoff point for the model was 0.12, where the specificity was 83.43%, the sensitivity was 77.42%, and the positive likelihood and negative likelihood ratios were 4.67 and 0.27, respectively. The model's predictive capability was superior to that of each single indicator.Conclusion: This study provides a non-invasive approach for predicting significant liver inflammation in CHB patients with normal ALT. Nomograms may help to identify target patients to allow timely initiation of antiviral treatment.
Policy and Food Consumption: What Nutrition Guidelines Are Swiss Children Meeting and What Determines Adherence?
Authors: Rangelov Natalie , Nogueira Avelar e Silva Raquel , Suggs L. Suzanne 
Published: June 2021

Objectives: To describe the adherence of the children to the Swiss Society for Nutrition (SSN) dietary guidelines, assess determinants of adherence, and compare these findings with a previous study in the same population.Methods: Data from 312 children ages 5–12 were collected through a survey and a 2-day food record. The associations of children- and parent-related factors with adherence of the children to guidelines were assessed by logistic regression analyses.Results: SSN guidelines were not met for any food category, although there were improvements: vegetables (4.5% in this study vs. 0% in the previous study), sweets, snacks, and soft drinks (SSD) (12.5 vs. 9.5%), and fruit (45.5 vs. 10.4%). Higher Body Mass Index (BMI) in children was associated with higher adherence to guidelines for protein intake. Higher parental BMI was associated with higher adherence to vegetables. Parental lower educational level was associated with higher adherence for cereal.Conclusion: Despite improvements since the last eating behavior assessment in this population, children consume too little fruit, vegetables, cereal, and milk and dairy products, and too much SSD and proteins. Further efforts are needed to promote healthy eating to children and achieve adherence to guidelines.
Neutropenia Is Not Associated With the Outcomes in Patients With Kawasaki Disease
Authors: Tang Yunjia , Gang Miao , Qian Weiguo , Ma Jin , Xu Qiuqin , Lv Haitao 
Published: June 2021

Objective: To investigate the outcomes of coronary artery lesions (CALs) and intravenous immunoglobulin (IVIG) resistance in patients with and without neutropenia during the disease course and to explore the relationships between Δ absolute neutrophils count (ΔANC) and the outcomes.Methods: We retrospectively reviewed the medical records of patients hospitalized in Children's Hospital of Soochow University with a main diagnosis of KD during January 2019 and December 2019. 1:4 propensity score matching was carried out to adjust the baseline characteristics. Smoothed plots and threshold effect analyses were performed to reveal the relationships between ΔANC and the outcomes.Results: Of the 438 patients enrolled, 75 (17.1%) were neutropenia cases and 363 (82.9%) were non-neutropenia cases. Patients with neutropenia were younger, had lower levels of initial ANC, white blood cell (WBC) count and C-reactive protein (CRP). Propensity score matching included 75 neutropenia and 247 non-neutropenia patients. No significant difference was found between neutropenia and non-neutropenia groups regarding CALs, coronary artery aneurysms, irregular coronary lumen, IVIG resistance and days of fever duration. There was a non-linear relationship between ΔANC and IVIG resistance. However, threshold effect analysis showed the incidence of IVIG resistance decreased with increasing ΔANC before the turning point (ΔANC = 1.6) (OR = 0.65, 95% CI = 0.50–0.8.4 P = 0.001). On the other hand, there was a linear relationship between ΔANC and CALs, even after adjusting the confounders (OR = 1.06, 95% CI = 1.02–1.11, P = 0.008).Conclusions: Neutropenia after IVIG was not exactly associated with the outcomes. However, ΔANC was in relation to CALs and IVIG resistance.