bluuebunny/crossref_metadata_2025_split huggingface dataset:
Una propuesta para administrar las TIC en el COBAY Valladolid
Authors: Santos Tejero Jesús Antonio , Ucán Pech Juan Pablo 
Published: October 2021

El uso efectivo de las Tecnologías de la Información y Comunicación (TIC) en la educación permite hacer que la enseñanza sea más fácil y rápida para los estudiantes. En este artículo, se presenta una propuesta de diseño e implementación de servicios de red para administrar los recursos tecnológicos que ofrece el Colegio de Bachilleres del Estado de Yucatán (COBAY), Valladolid, con esta propuesta la meta es la mejora y ampliación de los servicios de red disponibles en el mismo plantel. El COBAY, Plantel 10 ubicado en Valladolid Yucatán, es una institución educativa que imparte educación de nivel medio superior y cuenta con una infraestructura que incluye el uso de las TIC, sin embargo, específicamente en el área de redes, carece de los servicios que permitan optimizar los equipos y los recursos de red disponibles en el plantel, como la distribución y uso de Internet, así como de aplicaciones de apoyo a la docencia.
The effective use of Information Technology and Communications (ITC) in education makes teaching easier and faster for students. In this article, is presented a proposal of design and implementation of network services to manage technological resources offered by the college of bachelors in the state of Yucatán (COBAY) in Valladolid city, the goal with this proposal is the improvement and expansion of network services available on the Campus. El COBAY 10th campus located in Valladolid Yucatan, is an educational institution that provides mid-level education and it has an infrastructure that includes the use of ITC, however specifically on the network area, it has not enough services that allow to optimize the network services on the equipment available on the campus including the distribution and use of the internet and academic support.
Educación Mediática: un estudio correlacional en ambientes de aprendizaje colaborativo utilizando objetos de aprendizaje en la temática de Seguridad en las Redes
Authors: Burbano González Clara , Burbano González Carolina , Márceles Villalba Katerine , Barría Huidobro Cristian 
Published: October 2021

La presente Investigación se realiza en la Corporación Universitaria Unicomfacauca (Colombia), en el programa de Ingeniería de Sistemas en la asignatura de Seguridad Informática, “seguridad en las redes”. La metodología de Investigación científica aplicada tiene el enfoque total o mixto (cualitativo-cuantitativo). El diseño e implementación del objeto virtual de aprendizaje (OVA), cumple con los criterios de análisis y aplicación de gamificación y cuenta con las métricas de evaluación heurística en el contexto de la evaluación de la usabilidad en los sistemas interactivo. El presente artículo expone la propuesta generada desde la problematización en las mediaciones tecnológicas como formas de aprendizaje emergente desde varios prismas en la actual sociedad informacional. La educación mediática prescribe y delinea estudios enfocados en la aplicación y uso de las tecnologías de información y comunicación, por medio de la mediatización y mediación del recurso de información y comunicación con fundamento en los paradigmas analíticos aplicado al aprendizaje gamificado.
The present investigation was carried out in the University Corporation Unicomfacauca (Colombia), in the program of Systems Engineering in the subject of Computer Security, "Security in Networks". The methodology of applied scientific research has the total focus or mixed (qualitative-quantitative). The design and implementation of virtual learning object (OVA), meets the criteria for analysis and implementation of gamification and account with the metrics of heuristic evaluation in the context of the evaluation of the usability in interactive systems. This article exposes the proposal generated from the problematization in Technological mediations as emerging forms of learning from several prisms in the current society of informational. The media education prescribes and outlines studies focused on the implementation and use of information and communication technologies, by means of the media coverage and mediation of the resource of information and communication on the basis of the analytical paradigms applied to learning gamificate.
Estudio comparativo de técnicas de minería de datos para la predicción de rutas de huracanes
Authors: Coronado Arjona M.A. , Bianchi Rosado V. M. , Vivas Burgos J. A. , Perera Collí M.A. 
Published: October 2021

Los huracanes son las tormentas más grandes y violentas que pueden existir sobre la tierra. Su peligrosidad radica en la velocidad que pueden alcanzar sus vientos, llegando a superar los 250 kilómetros por hora y desatando 9 billones de litros de lluvia al día, en consecuencia, sus efectos son a gran escala y con frecuencia muy destructivos en pérdidas humanas y materiales. A sabiendas de la inexactitud en las trayectorias, muchos habitantes esperan hasta el último momento antes de abandonar su hogar y pertenencias con la esperanza de que el fenómeno meteorológico cambie su curso. Es por esto que surge la necesidad de determinar la mejor técnica para predecir rutas de huracanes. El estudio consistió en entrenar los algoritmos de las técnicas de predicción, regresión lineal, k vecinos más cercanos y perceptrón multicapa, para obtener los modelos que permitan la comparación de datos predictivos con las trayectorias reales de huracanes y así determinar la exactitud de la predicción. Se encontró que la técnica de regresión lineal obtuvo los mejores resultados.
Hurricanes are the largest and most violent storms that exist on Earth. Their dangerousness lies in the speed that can reach their winds, reaching over 250 km per hour and unleashing 9 billion liters of rain a day, so their effects are large scale and very destructive. Due to the effects mentioned before, the number of human and material losses are high. This is because of the inaccuracy in trajectories and many inhabitants wait until the last moment to leave their home and belongings, in the hope that the weather phenomenon will change its course. In this way arises the need to find the best hurricane prediction technique. The study consisted in training the algorithms of prediction techniques, linear regression, k nearest neighbors and multilayer perceptron, to obtain the models that allow the comparison of predictive data with the actual hurricane trajectories and thus determine the accuracy of the prediction. It was found that the linear regression technique obtained the best results.
Evaluación de la usabilidad en aplicaciones domóticas móviles usando el método de recorrido cognitive
Authors: Coronado Arjona M.A. , Bianchi Rosado V. M. , Vivas Burgos J. A. 
Published: October 2021

La domótica es un conjunto de tecnologías hardware y software que se utiliza en la automatización de los hogares. A través de un software llamado aplicación domótica, las personas pueden acceder a los electrodomésticos independientemente si están dentro o fuera del hogar. La falta de aplicaciones que consideren las necesidades de la gente de la tercera edad, representa una problemática en el ámbito de acción de la domótica toda vez que la mayoría de los sistemas software están diseñados por gente joven y para gente joven [1], esto conlleva a que en muy pocas ocasiones sean tomadas en cuenta las características, necesidades y problemas de las personas de la tercera edad y consideradas en el diseño de aplicaciones que automaticen el hogar y por consecuencia no se alcancen los objetivos que la domótica promueve de proteger y facilitar la vida del adulto mayor. Considerándolos como población objetivo de este estudio, se optó por la evaluación de la usabilidad utilizando el método de recorrido cognitivo.
Domotics is a set of hardware and software technologies that is used in home automation. With software called domotics applications, people can access to appliances, regardless of whether they are at home or outside them. The lack of applications that consider the needs of the elderly represents a problem in the field of domotics, since most software systems are designed by young people to young people. This means that the characteristics, needs and problems of the elderly are considered in very few occasions in the design of applications that automate the home. Consequently, the goals that domotics promotes to protect and facilitate the life of the elderly are not achieved. Considering them as the target population of this study, we chose the usability evaluation through the cognitive walkthrough method.
Héroes y leyendas de Popayán: un juego serio basado en realidad aumentada para la apropiación del patrimonio.
Authors: Vidal Caicedo M.I. , Camacho Ojeda M.C. , Burbano Ceron P.D. , Muñoz Muñoz H.F. , Agredo Echavarria V.H. 
Published: October 2021

El patrimonio cultural constituye una de las riquezas más importantes de los pueblos, preservar los espacios históricos es una función social, sin embargo la preservación de los sitios históricos depende de la apropiación que tengan las personas que residen en esos lugares. En los últimos años se han desarrollado aplicaciones que buscan comunicar la importancia del patrimonio haciendo uso de tecnologías como la realidad aumentada y los juego serios, la tecnología permite llegar a diferentes espacios incluso a los que físicamente ya no existen y viajar en el tiempo a épocas pasadas, por lo cual se convierten estas herramientas en facilitadores de la apropiación del patrimonio. En este artículo se presenta un juego serio que emplea realidad aumentada para crear una experiencia de inmersión.
The cultural heritage is one of the most important riches of the people, preserve the historical spaces is a social function. However, the preservation of historical sites depends on the appropriation that have people living in those places. In recent years, applications have been developed that seek to communicate the importance of heritage using of technologies such as augmented reality and serious games. The technology allows to get places even those who physically no longer exist and also travel to the past, so these tools become facilitators of the appropriation of heritage. This paper presents a serious game that uses augmented reality to create an immersive experience.
Influencia del uso de las TICs en los ingresos económicos de la pesca artesanal en Santa Rosa, Salinas
Authors: Mendoza Morán B. M. , Mendoza Morán V. R. , Garzozi Pincay R. F. , Garzozi Pincay Y. S. 
Published: October 2021

En la ciudad de Salinas, provincia de Santa Elena, la actividad de la pesca artesanal es una actividad ancestral que mueve la economía local y de la cual dependen aproximadamente 7.000 familias. En la actualidad, las TIC’s han llegado a todos los sectores de la sociedad, ya sea por sus prestaciones y por su sencillez de uso. Los pescadores artesanales utilizan para su faena diaria equipos de comunicación y geoposición como: GPS, Radios de Onda Corta y celulares como herramientas de ayuda para su trabajo. La presente investigación tiene como objetivo determinar el nivel de utilización de los equipos de comunicación y ubicación, y su influencia sobre el ingreso económico de los pescadores artesanales de la parroquia Santa Rosa del cantón Salinas, provincia de Santa Elena, Ecuador (2017).
In the city of Salinas province of Santa Elena, the activity of the artisanal fishing is an ancestral activity that moves the local economy and of which 7.000 families depend. Nowadays ICT has reached all sectors of society and the sea for its benefits and for its capacity of use, artisanal fishermen use for communication and navigation equipment such as: GPS, Short Wave Radios, cellular as a tool Help for your work. The present research aims to determine the level of utilization of communication and location equipment and their impact on the economic income of artisanal fishermen from the Santa Rosa parish of Salinas, Santa Elena Province, Ecuador (2017).
Diseño y Aplicación de un Instrumento de Evaluación Diagnóstica para el Programa Académico de Informática de la Universidad Autónoma de Nayarit
Authors: Olivares Granados Sergio Agustín , González Reyes Janoe Antonio 
Published: October 2021

La Evaluación Intermedia para los programas de licenciatura tiene como propósito la detección e implementación de estrategias que permitan corregir anomalías en los programas de estudio tales como la similitud de contenidos entre diferentes unidades de aprendizaje o temas no cubiertos durante la impartición de los cursos. Este documento da cuenta de la experiencia en la instrumentación la evaluación intermedia en el año 2015 para el programa académico de Informática que pertenece a la Unidad Académica de Economía en la Universidad Autónoma de Nayarit, particularmente en la elaboración del instrumento y el método que se siguió para la construcción del mismo, al final se presentan algunos resultados y conclusiones posteriores a la aplicación respecto a esta experiencia que involucro a docentes, personal administrativo y directivo de la Unidad Académica y de la propia Universidad.
The porpoise for an interim assessment in a Bachelor’s degree program is to detect and enforce strategies that leads to solve studies program anomalies. This document reports the 2015 experience on apply an interim assessment for a computing bachelors program at the Academic Unit of Economics in the Nayarit’s Autonomous University, specially about the instrument and it’s processing method, in the end some results and conclusions are presented about this experience where teachers, administrators and managers from the Academic Unit and the University itself were involved.
Silent Genes: Antimicrobial Resistance and Antibiotic Production
Authors: STASIAK MONIKA , MAĆKIW ELŻBIETA , KOWALSKA JOANNA , KUCHAREK KATARZYNA , POSTUPOLSKI JACEK 
Published: October 2021

Abstract
Silent genes are DNA sequences that are generally not expressed or expressed at a very low level. These genes become active as a result of mutation, recombination, or insertion. Silent genes can also be activated in laboratory conditions using pleiotropic, targeted genome-wide, or biosynthetic gene cluster approaches. Like every other gene, silent genes can spread through horizontal gene transfer. Most studies have focused on strains with phenotypic resistance, which is the most common subject. However, to fully understand the mechanism behind the spreading of antibiotic resistance, it is reasonable to study the whole resistome, including silent genes.
Barreiras enfrentadas por mulheres vivendo com o HIV no relacionamento afetivo-sexual: revisão integrativa
Authors: Barros Alice Nunes de , Barros Júlia Rodrigues Guimarães , Alves Regina de Souza , Santos Priscilla Souza dos , Lima Flávia dos Santos , Calixto Débora Mical de Almeida , Melo Beatriz Raquel Fonseca dos Santos , Reis Renata Karina 
Published: October 2021

O presente trabalho tem como objetivo buscar evidências na literatura sobre as barreiras enfrentadas por mulheres vivendo com o HIV no relacionamento afetivo-sexual. Trata-se de uma revisão integrativa de literatura, feita por levantamento bibliográfico nas bases de dados Scientific Eletronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Banco de Dados em Enfermagem (BDENF) e US National Library of Medicine National Institutes of health (PubMed) durante o mês de setembro de 2020. Os critérios de inclusão foram estudos publicados na íntegra no período de 2015 a 2020, no idioma português e inglês que estivessem disponíveis gratuitamente online. Foram descartados os artigos duplicados, monografia, dissertação, tese, revisões e os que não corresponderam ao objetivo da pesquisa. Foram identificados 2.090 artigos, mas somente 7 artigos atenderam aos critérios de inclusão e exclusão. Sendo quatro (57,2%) encontrados na SciELO, dois (28,6%) na BDENF e um (14,2%) no LILACS. O presente estudo permitiu perceber que os principais obstáculos enfrentados por mulheres vivendo com o HIV no aspecto afetivo-sexual são de cunho emocional, psicológico e social, tornando-se notáveis os diversos impactos que o diagnóstico do HIV causa na vida das mulheres.
GEDpm-cg: Genome Editing Automated Design Platform for Point Mutation Construction in Corynebacterium glutamicum
Authors: Yang Yi , Mao Yufeng , Liu Ye , Wang Ruoyu , Lu Hui , Li Haoran , Luo Jiahao , Wang Meng , Liao Xiaoping , Ma Hongwu 
Published: October 2021

Advances in robotic system-assisted genome editing techniques and computer-aided design tools have significantly facilitated the development of microbial cell factories. Although multiple separate software solutions are available for vector DNA assembly, genome editing, and verification, by far there is still a lack of complete tool which can provide a one-stop service for the entire genome modification process. This makes the design of numerous genetic modifications, especially the construction of mutations that require strictly precise genetic manipulation, a laborious, time-consuming and error-prone process. Here, we developed a free online tool called GEDpm-cg for the design of genomic point mutations in C. glutamicum. The suicide plasmid-mediated counter-selection point mutation editing method and the overlap-based DNA assembly method were selected to ensure the editability of any single nucleotide at any locus in the C. glutamicum chromosome. Primers required for both DNA assembly of the vector for genetic modification and sequencing verification were provided as design results to meet all the experimental needs. An in-silico design task of over 10,000 single point mutations can be completed in 5 min. Finally, three independent point mutations were successfully constructed in C. glutamicum guided by GEDpm-cg, which confirms that the in-silico design results could accurately and seamlessly be bridged with in vivo or in vitro experiments. We believe this platform will provide a user-friendly, powerful and flexible tool for large-scale mutation analysis in the industrial workhorse C. glutamicum via robotic/software-assisted systems.
Diagnostic Role of Extracellular Vesicles in Cancer: A Comprehensive Systematic Review and Meta-Analysis
Authors: Liu Shu-ya , Liao Yin , Hosseinifard Hossein , Imani Saber , Wen Qing-lian 
Published: October 2021

Background: Cancer-derived extracellular vesicles (EVs) are regarded to have significant function in most steps during cancer progression. This meta-analysis aims to investigate the accuracy of EVs as a biomarker in cancer diagnosis.Methods: The diagnostic efficacy of EVs for different cancers was assessed using pooled sensitivity and specificity, diagnostic odds ratio (DOR), and overall area under the curve (AUC) of the summary receiver operating characteristic (SROC). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were verified to estimate the diagnostic efficacy of EV at a clinical level.Results: In all, 6,183 cancer patients and 2,437 healthy controls from 75 eligible studies reported in 42 publications were included in the study. The overall pooled sensitivity, specificity, PLR, NLR, and DOR were 0.62 (95% CI: 0.60–0.63), 0.76 (95% CI: 0.75–0.78), 3.07 (95% CI: 2.52–3.75), 0.34 (95% CI: 0.28–0.41), and 10.98 (95% CI: 7.53–16.00), respectively. Similarly, the AUC of the SROC was 0.88, indicating a high conservation of EVs as an early diagnostic marker. Furthermore, subgroup analysis suggested that the use of small EVs as a biomarker was more accurate in serum-based samples of nervous system cancer (p &lt; 0.001). As a result, ultracentrifugation and quantification and size determination methods, such as Western blotting and ELISA were the most reliable identification methods for EV detection. We also indicated that increased secretion of EVs made them a capable biomarker for diagnosing cancer in elderly European individuals.Conclusions: Our study provides evidence that EVs are a promising non-invasive biomarker for cancer diagnosis. Well-designed cohort studies should be conducted to warrant the clinical diagnostic value of EVs.
Neutrophils and Lymphocytes Can Help Distinguish Asymptomatic COVID-19 From Moderate COVID-19
Authors: Gu Xuefeng , Sha Ling , Zhang Shaofeng , Shen Duo , Zhao Wei , Yi Yongxiang 
Published: October 2021

IntroductionAsymptomatic coronavirus disease 2019 (COVID-19) and moderate COVID-19 may be the most common COVID-19 cases. This study was designed to develop a diagnostic model for patients with asymptomatic and moderate COVID-19 based on demographic, clinical, and laboratory variables.MethodsThis retrospective study divided the subjects into 2 groups: asymptomatic COVID-19 (without symptoms, n = 15) and moderate COVID-19 (with symptoms, n = 57). Demographic characteristics, clinical data, routine blood tests, other laboratory tests, and inpatient data were collected and analyzed to compare patients with asymptomatic COVID-19 and moderate COVID-19.ResultsComparison of the asymptomatic COVID-19 group with the moderate COVID-19 group yielded the following results: the patients were younger (P = 0.045); the cluster of differentiation (CD)8+ (cytotoxic) T cell level was higher (P = 0.017); the C-reactive protein (CRP) level was lower (P = 0.001); the white blood cell (WBC, P &lt; 0.001), neutrophil (NEU, P = 0.036), lymphocyte (LYM, P = 0.009), and eosinophil (EOS, P = 0.036) counts were higher; and the serum iron level (P = 0.049) was higher in the asymptomatic COVID-19 group. The multivariate analysis showed that the NEU count (odds ratio [OR] = 2.007, 95% confidence interval (CI): 1.162 - 3.715, P = 0.014) and LYM count (OR = 9.380, 95% CI: 2.382 - 36.934, P = 0.001) were independent factors for the presence of clinical symptoms after COVID-19 infection. The NEU count and LYM count were diagnostic predictors of asymptomatic COVID-19. This diagnostic prediction model showed high discriminatory power, consistency, and net clinical benefits.ConclusionsThe proposed model can distinguish asymptomatic COVID-19 from moderate COVID-19, thereby helping clinicians identify and distinguish patients with potential asymptomatic COVID-19 from those with moderate COVID-19.
Donor-Derived Human Parvovirus B19 Infection in Kidney Transplantation
Authors: Yu Yedong , Wei Chunchun , Lyu Junhao , Wu Xiaoliang , Wang Rending , Huang Hongfeng , Wu Jianyong , Chen Jianghua , Peng Wenhan 
Published: October 2021

BackgroundDonor-derived human parvovirus B19 (B19V) infections are rarely reported. Thus, its incidence in kidney transplantation is still unknown due to lack of surveillance studies. Similarly, whether the donor needs to be routinely screened for B19V and whether the kidneys from those with B19V DNAemia could be accepted also remain unknown.MethodsThis retrospective study aims to evaluate the donor-derived B19V infections occurring in 823 living and 1,225 deceased donor kidney transplantations from January 2016 to December 2020. The serum viral load of living donors and their corresponding recipients was evaluated before and after transplantation. Meanwhile, for the deceased donor kidney transplantation, the serum viral load of recipients was only tested after transplantation; if recipients of a deceased donor subsequently developed B19V infection, the serum viral load of recipients and their corresponding donors before transplantation would then be further traced.ResultsA total of 15 living donors were B19V DNAemia positive before the donation, of which B19V DNAemia occurred in three corresponding recipients. In deceased donor kidney transplantation, DNAemia occurred simultaneously in 18 recipients and their corresponding nine donors. A progressive decline in hemoglobin and reticulocyte count could be observed in one living donor recipient and other 11 deceased donor recipients, which were all well controlled by treatment eventually.ConclusionThe incidence of donor-derived B19V infection was 0.4% and 1.5% in living and deceased kidney transplantations, respectively. B19V was seemingly unnecessary to be routinely screened for the donor. Moreover, kidneys of the donors with B19V infection were acceptable.