bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining retirement savings building and depleting behavior
Authors: Sargent Carol Springer , Balasubramnian Bhanu , Bowler Blake D. , Lambert Charles Asa 
Published: January 2025

PurposeAround the globe, low retirement savings threaten the economic well-being of large portions of the population. To better understand what promotes retirement sufficiency, we investigate variables that correlate with retirement savings behaviors.Design/methodology/approachUsing the 2021 National Financial Capability Study data, we examine factors correlated with having a retirement plan, contributing to a retirement plan and avoiding the depletion of retirement savings.FindingsWhile strong financial behavior and actual financial literacy are each connected to retirement plan participation, the link attributed to strong financial behavior is nearly twice as strong as that for actual financial literacy. Strong financial behavior correlates strongly with leaving retirement savings in place. Having a financial literacy blind spot (i.e. not knowing that one does not know about financial literacy) correlates strongly with retirement savings depletion. Financial anxiety does not correlate with retirement plan participation or depletion.Originality/valueOur measure of strong financial behavior explains much more variation in retirement savings than variables commonly explored in the retirement literature. Individuals facing income constraints without a financial literacy blind spot are less likely to deplete their retirement savings. Conversely, those with a financial literacy blind spot tend to deplete their retirement savings regardless of their financial vulnerability or strength. Our findings hold even when restricting the sample to households with incomes below the median ($75,000), as well as above the median, indicating that policies targeting non-income variables could enhance retirement outcomes.
Unveiling workplace dynamics: insights from voluntary disclosures on business outlook and CEO approval
Authors: Kock Ned , Haddoud Mohamed Yacine , Onjewu Adah-Kole , Yang Shiyu 
Published: January 2025

PurposeThis inquiry extends the discourse on job satisfaction and employee referral. It aims to examine the moderating effects of perceived business outlook and CEO approval in the dynamics of job satisfaction and employee referral. A model predicting job satisfaction and employee referral through the lens of Herzberg’s two-factor theory is developed and tested.Design/methodology/approachTo remedy the overreliance on self-reported surveys, impeding generalization and representativeness, this study uses large evidence from 14,840 voluntary disclosures of US employees. A structural equation modeling technique is adopted to test the hypotheses.FindingsThe inherent robust path analysis revealed intriguing findings highlighting culture and values as exerting the most substantial positive impact on job satisfaction, while diversity and inclusion played a relatively trivial role. Moreover, employees’ view of the firms’ outlook and their approval of the incumbent CEO were found to strengthen the job satisfaction–referral nexus.Originality/valueThe study revisits the relationship between job satisfaction and employee referral by capturing the moderating effects of perceived business outlook and CEO approval. We believe that this investigation is one of the first to capture the impact of these two pivotal factors.
A review of public opposition to the establishment of construction and demolition waste recovery facilities
Authors: Behzad Moein , Shooshtarian Salman , Maqsood Tayyab 
Published: January 2025

PurposeUrban expansion in recent decades has led to a surge in new buildings and infrastructure, significantly increasing construction and demolition (C&D) waste materials. This large waste stream presents environmental challenges, prompting stakeholders in the construction and waste recovery sectors to establish waste recovery facilities. However, these infrastructure projects often face public opposition. This research aims to identify the root causes of public opposition to C&D waste recovery facilities and propose strategies to manage and mitigate these concerns effectively.Design/methodology/approachThis research adopts a qualitative approach to extract relevant literature using the PRISMA model, which is common for systematic reviews. A set of selection criteria were used to extract the most relevant literature in this field. The analysis methods are based on bibliometric analysis as well as document analysis.FindingsThe research findings indicate that five major categories impact the public’s perceptions of C&D waste recovery facilities. These categories include environmental, awareness and perception, economic, health, safety and well-being and project management. Furthermore, the research provides eight strategies to effectively manage public opposition to waste recovery facilities.Research limitations/implicationsThis research provides a framework for managing public opposition to C&D waste recovery infrastructure projects fairly and efficiently. Comprising six steps with specific actions, the framework addresses citizens’ concerns while improving C&D waste recovery rates. It serves as a strategic roadmap that can be adapted for use in various infrastructure projects, fostering community support and sustainable development.Originality/valueThis review paper is the first attempt to gather causes for public opposition to the development of C&D waste recovery facilities. The research findings can guide policymakers who strive to establish a fair framework for all stakeholders affected by or involved in the establishment of C&D waste recovery facilities.
Remote sensing reveals scale‐specific effects of forage crop mowing and landscape structure on a declining farmland bird
Authors: Andreatta Davide , Bazzi Gaia , Nardelli Riccardo , Siddi Leonardo , Cecere Jacopo G. , Chamberlain Dan , Morganti Michelangelo , Rubolini Diego , Assandri Giacomo 
Published: January 2025

Abstract

The effectiveness of agri‐environment schemes (AESs), the largest conservation‐related expenditure for farmland biodiversity conservation within the European Union, is often compromised by a limited spatial scale of implementation. We focused on multiannual forage crops, a surrogate habitat for grassland birds, to assess the scale‐dependent effects of mowing timing and frequency on the local population size of an iconic species, the skylark (Alauda arvensis). While there is much evidence for a negative impact of in‐field mowing activities on grassland birds, whether such effects occur also at broader spatial scales is largely unknown.

We surveyed breeding skylarks in the Po Plain (northern Italy) to determine (1) the association between landscape composition/configuration and abundance and (2) how abundance is affected by forage crop mowing timing and frequency. We addressed both questions through scale optimisation, identifying the most influential spatial scales for each covariate. Forage crop mowing timing was assessed through a novel remote sensing algorithm based on high‐resolution Sentinel‐2 satellite images.

We observed a strong scale dependence on the importance of different habitats in determining skylark abundance. Abundance increased with an increasing cover of forage crops locally (200 m) and of winter crops at a landscape scale (2600 m), suggesting that the species is favoured by heterogeneous agroecosystems. Locally (150–350 m), skylarks were more abundant when crops were aggregated, being negatively impacted by crop fragmentation caused by urbanization and by seminatural habitats.

At the landscape scale (1150 m), the timing of mowing was consistent across years, with early‐mown areas supporting fewer skylarks. This is probably because, over longer temporal scales, early‐mown forage patches have limited or null productivity, eventually limiting local population size.

Synthesis and applications. We provide a new perspective on the overarching influence of spatial scale in driving the abundance of a declining farmland bird species, supporting the urgency of designing landscape scale‐effective AESs. This should be framed within the new EU Common Agricultural Policy reform and operated by farmer collectives, whereby management interventions should be monitored by state‐of‐the‐art remote sensing techniques. These results suggest that implementing scale‐optimized AESs could be crucial for effective farmland biodiversity conservation.
Adaptive Capacity in a Crisis: Turbulence Managers in Street‐Level Organizations
Authors: Alirani Gertrud , Oscarsson Olof , Olausson Pär M. , Danielsson Erna 
Published: January 2025

ABSTRACTThis study explores the adaptive capacity of managers in street‐level organizations (SLOs) in response to global crises. Using a Swedish municipality as a case study, we explore the challenges encountered by managers during the extended COVID‐19 pandemic. The abilities required to manage the crisis differ from the challenges and skills typically associated with professional crisis managers. We propose the term ‘turbulence manager’ to describe the unique challenges in SLOs and the skills required to navigate the situation, particularly the delicate balance between crisis management and regular duties. In conclusion, this study emphasizes the crucial role of SLO managers in crisis adaptation, highlighting their ability to mitigate the impact of turbulence by creatively adjusting their existing routines.
Rethinking the pan scan in stable trauma: A comparison of whole‐body computed tomography and selective imaging in clinically stable blunt force trauma
Authors: Kerslake Milo , Chui Yingbin , Pham Tan‐Phu , Dinh Michael , Kaikhosrovi Mahsa , Bennett Katherine , Oliver Matthew 
Published: January 2025

AbstractObjectiveTo compare the frequency of clinically significant missed injuries in clinically stable trauma patients undergoing initial whole‐body computed tomography (WBCT) versus selective imaging. Secondary objectives include comparisons of radiation exposure, incidental findings, ED length of stay (LOS), hospital LOS and mortality.MethodsWe performed a retrospective cohort study of trauma activations at a tertiary trauma centre in patients with normal vital signs from 1st January 2022 to 31st December 2022. Data were collected from the trauma registry and chart review of medical records.ResultsA total of 665 patients were included with 42% (n = 277) receiving a WBCT, compared to 58% (n = 388) undergoing selective imaging. Most patients (52%) did not have any traumatic axial injuries identified. Missed injuries were identified in 0.8% (n = 3/388) of patients in the selective imaging cohort, with no adverse patient outcomes or major alteration to inpatient management. No missed injuries were identified in the WBCT group. Mortality was rare (0.9%, n = 6/665), occurring exclusively in elderly patients and mostly attributed to non‐traumatic pathologies. Patients undergoing WBCT had a significantly increased likelihood of incidental findings (75% vs 35%, P < 0.001), increased radiation exposure (mean 24.67 vs 8.19 millisieverts [mSv], P < 0.001), longer ED LOS (9.86 vs 8.43 h, P = 0.012) and a higher likelihood of admission (65.3% vs 55.7%, P = 0.012).ConclusionsMissed injuries were rare and without major complications in this clinically stable cohort. The liberal use of WBCT, despite low rates of missed injuries, morbidity and mortality, suggests over‐utilisation of WBCT for ‘mechanism only’ traumas.
circSIRT2/miR‐542‐3p/VASH1 axis regulates endothelial‐to‐mesenchymal transition (EndMT) in subretinal fibrosis in age‐related macular degeneration models
Authors: Zhang Min , Wu Jiali , Wang Yimin , Wu Yidong , Wan Xiaoling , Jiang Mei , Bo Qiyu , Chen Jieqiong , Sun Xiaodong 
Published: January 2025

AbstractNeovascular age‐related macular degeneration (nAMD), characterized by choroidal neovascularization (CNV), is one of the leading causes of severe visual impairment and irreversible vision loss around the world. Subretinal fibrosis (SRF) contributes to the incomplete response to anti‐vascular endothelial growth factor (VEGF) treatment and is one of the main reasons for long‐term poor visual outcomes in nAMD. Reducing SRF is urgently needed in the anti‐VEGF era. The role of non‐coding RNAs has been implicated in CNV; however, their roles in SRF have not been elucidated yet. Herein, we comprehensively investigated circular RNA (circRNA) profiles in the laser‐induced mouse SRF model and the transforming growth factor‐β (TGF‐β) induced human umbilical vein endothelial cell (HUVEC) fibrosis model. A novel circRNA, circSIRT2, was identified, and its function in SRF and endothelial‐to‐mesenchymal transition (EndMT) regulation was investigated. circSIRT2 was consistently upregulated in fibrotic models in vivo and in vitro. circSIRT2 overexpression downregulated the fibrotic markers and inhibited the proliferation and migration of endothelial cells in vitro. circSIRT2 overexpression in vivo also reduced SRF area in mice. Mechanistically, circSIRT2 functioned by sponging miR‐542‐3p, which further upregulated the expression of vasohibin‐1 (VASH1) and reduced SRF lesion development. Vitreous delivery of miR‐542‐3p and VASH1 in the mouse SRF model also confirmed the pro‐fibrotic function of miR‐542‐3p and anti‐fibrotic function of VASH1, respectively. In conclusion, circSIRT2 inhibited SRF by binding miR‐542‐3p, which stimulated the VASH1 expression and subsequently suppressed EndMT. The circSIRT2/miR‐542‐3p/VASH1 axis may serve as a promising therapeutic target for SRF in nAMD.
Age‐Related Dynamics and Spectral Characteristics of the TCRβ Repertoire in Healthy Children: Implications for Immune Aging
Authors: Fang Mingyan , Miao Yu , Zhu Lin , Mei Yunpeng , Zeng Hui , Luo Lihua , Ding Yuan , Zhou Lina , Quan Xueping , Zhao Qin , Zhao Xiaodong , An Yunfei 
Published: January 2025

ABSTRACTT‐cell receptor (TCR) diversity is crucial for adaptive immunity, yet baseline characterizations in pediatric populations remain sparse. We sequenced the TCRβ chain of 325 healthy Chinese children aged 0–18, categorized into six age groups. We also analyzed cellular composition and TCRβ associations using flow cytometry in 81 of these samples. Our results indicate a decrease in TCRβ diversity with age, characterized by an increase in high‐frequency clonotypes and notable changes in CDR3 length and V(D)J gene usage. These changes are influenced by early life vaccinations and antigen exposures. Additionally, we found a significant association between reduced TCRβ diversity and a decrease in CD4+ T naïve cells. We also developed a predictive model that identifies specific TCRβ features as potential biomarkers for biological age, validated by their significant correlation with changes in the immune repertoire. These findings enhance our understanding of age‐related variations in the TCRβ repertoire among children, providing resourceful information for research on pediatric TCR in health and disease.
Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice
Authors: Tian Xiaoxue , Kan Hao , Yang Liu , Wang Zhiwei , Zhang Tiantian , Zhang Ka , Mao Aiqin , Wen Xin , Zhou Tingting , Wang Xiaoyan , Zhang Xiaodong , Feng Lei , Geng Li 
Published: January 2025

ABSTRACTEndothelial dysfunction, characterized by a decline in endothelial physiological functions, is a significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), a key member of Ca2+‐permeable channels, plays a crucial role in maintaining vascular functions. However, the role and mechanisms of TRPV4 in aging‐related endothelial dysfunction remain incompletely understood. Here, we demonstrated a marked reduction in endothelial TRPV4 function without alterations in its expression, leading to abnormal endothelial Ca2+ signaling and impaired vasodilation in aging mesenteric arteries. Employing transcriptome sequencing, co‐IP, and PLA assays, we characterized G protein‐coupled receptor 35 (GPR35) interacting with TRPV4, and abnormally enhanced interactions were found in aging endothelial cells. Subsequently, we revealed that intensive GPR35‐TRPV4 interaction significantly contributes to endothelial dysfunction during aging, utilizing TRPV4 endothelial‐specific knockout (TRPV4EC−/−), AAV‐FLT1‐shRNA (GPR35) mice, and GPR35 overexpressed/knocked‐down HUVECs. Furthermore, molecular docking analysis and subsequent co‐IP and pressure myograph experiments indicated that both Thonningianin A and Carfilzomib efficiently restored the GPR35‐TRPV4 interaction, preventing endothelial dysfunction and vasodilation impairment. Our study identifies the crucial role of GPR35‐TRPV4 interaction in aging‐associated abnormal endothelial function and vascular tone modulation. Restoring GPR35‐TRPV4 interaction via Thonningianin A or Carfilzomib represents a promising precision approach for aging‐related endothelial dysfunction.
Risk Factors for Antepartum Haemorrhage in Women With Placenta Praevia
Authors: Treffers A. , Reynoldson O. , Beckmann M. 
Published: January 2025

ABSTRACTBackgroundPlacenta praevia (PP) is a significant obstetric complication associated with antepartum haemorrhage (APH) and adverse maternal and fetal outcomes. Identifying risk factors for APH in women with PP is important for guiding management decisions.AimsThis study aimed to identify risk factors associated with APH amongst women admitted to a single tertiary hospital with PP.Materials and MethodsA retrospective cohort study was undertaken, utilising data from the hospital's maternity dataset (2007–2021) and included publicly funded women with PP after 24 weeks gestation. Exclusions comprised multiple pregnancies, fetal abnormalities, intra‐uterine fetal death and deliveries at other hospitals. Baseline characteristics, outcomes and potential risk factors for APH were analysed through bivariate and stepwise logistic regression.ResultsOf the 430 cases with PP, 112 (26%) were admitted with APH. Of these, 45 had two or more admissions with APH, constituting 40% of the APH cohort. Those requiring admission were more likely to deliver at an early gestation, and their baby required nursery admission. Factors independently associated with APH included a higher number of previous caesarean sections, parity, Caucasian ethnicity and major PP.ConclusionsMost women with PP will not require an admission with APH. In considering inpatient versus outpatient management, multiparous Caucasian women with a major PP appear more likely to be at risk of APH admission and premature delivery. These findings underscore the importance of tailoring clinical decision‐making.
Portuguese Society of Ophthalmology and Portuguese Society of Human Genetics Joint Clinical Practice Guidelines for Genetic Testing in Inherited Retinal Dystrophies
Authors: Marques João Pedro , Soares Célia Azevedo , Carvalho Ana Luísa , Estrela‐Silva Sérgio , Santos Luísa Coutinho , Ramos Lina , Silva Eduardo 
Published: January 2025

ABSTRACTThe Portuguese Society of Ophthalmology and the Portuguese Society of Human Genetics developed clinical practice guidelines to streamline genetic testing for inherited retinal dystrophies (IRDs), underlining the critical role of molecular diagnosis in enhancing patient care. Genetic testing is pivotal in diagnosis, genetic counselling, prognosis and access to clinical trials, and new gene‐specific therapies. These guidelines recommend genetic testing in all IRD patients and provide a detailed assessment of available testing methods, ensuring that genetic counselling is integrated into ophthalmic care. Essential to this process is the inclusion of at least one genetic counselling session to effectively communicate and discuss implications of test results with patients and families/carers. Key recommendations include cascade testing to identify at‐risk family members and standardisation of variant classification according to international criteria to ensure consistency in diagnosis and care. Ophthalmological follow‐up is generally prescribed at intervals of 1–2 years for adults and 6 months for paediatric patients, to monitor disease progression and complications. Paediatric considerations are addressed, reflecting the complexities and ethical concerns associated with testing minors. These guidelines aim to elevate diagnostic accuracy, guide therapeutic decisions and ultimately improve patient outcomes, marking a significant advance in the genetic management of IRDs.
Diagnostic accuracy of early neonatal MRI in predicting adverse motor outcomes in children born preterm: Systematic review and meta‐analysis
Authors: Mistry Karen H. , Boyd Roslyn N. , Pagnozzi Alex M. , Bora Samudragupta , Ware Robert S. , George Joanne M. 
Published: January 2025

AbstractAimTo examine the diagnostic accuracy of Early structural and diffusion‐weighted magnetic resonance imaging (MRI) (acquired at < 36 weeks postmenstrual age) to detect cerebral palsy (CP) or other adverse motor outcomes at or beyond 3 years corrected age in infants born preterm.MethodIn this systematic review and meta‐analysis, we searched the CINAHL, Embase, PubMed, and Web of Science databases for studies without language restrictions and a prospectively registered protocol up to October 2023. We extracted the study details, associations presented, and meta‐analyses conducted with pooled sensitivity and specificity.ResultsTwenty‐seven articles met the overall inclusion criteria. White matter injury, cerebellar haemorrhage, intraventricular haemorrhage, and lower thalamic volume were associated with poorer motor outcomes. Abnormal Early structural MRI detected infants with a later diagnosis of CP (n = 448, eight studies) with a pooled sensitivity of 98% (95% confidence interval [CI] = 86–100), specificity of 75% (95% CI = 51–93), and adverse motor outcomes (n = 215, four studies), with a pooled sensitivity of 39% (95% CI = 20–59) and a specificity of 90% (95% CI = 88–94).InterpretationEarly abnormal structural MRI predicted later CP with high sensitivity and specificity, while specificity was higher than sensitivity in predicting adverse motor outcomes using the Movement Assessment Battery for Children, Second Edition. Further research into diagnostic accuracy and association between Early MRI and long‐term motor outcomes is warranted.