bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEBERHASILAN MENGEMBANGKAN USAHA MIKRO (Studi Kasus Buah-buahan Ibu Wartini)
Authors: Santika Ledia , Rizkan Rizkan , Gusti Ririn 
Published: June 2021

The fruit business of Mrs. Wartini is is a micro business different from the fruit business in general, because in addition to selling fruits, there are many other sales variations of processed fruits. Thus, the selling differences based on Mrs. Wartini's fruit business are what make researchers interested in conduct research. The purpose of this study is first, to describe the characteristics of success in developing micro-businesses which include orientation to achievement, courage to take risks, hard work, responsibility, commitment and develop and maintain good relations. The research method used in this research is descriptive qualitative method. The results obtained are as follows: first, the aspect of orientation on achievement is the quality of fresh products, many variations of sales and affordable prices. Second, the aspect of courage to take risks is to open a business and dare to stock a lot of fruits. Third, the aspect of hard work, which is employees who arrive early. Fourth, the aspect of responsibility that is paying employees' salaries and fruit suppliers is always on time. Fifth, the aspect of commitment is to the time and tengga issued and always provide immediate fruit. Sixth, aspects of developing and maintaining good relations, namely the existence of a good relationship between the owner and employees, customers and fruit suppliers. Keywords: Success, Business, Micro
PERAN DPRD DALAM MEMBANGUN PEMERINTAHAN YANG BAIK DAN BERWIBAWA
Authors: Nurochman Nurochman 
Published: June 2021

DPRD Kota Batu berusaha maksimal membangun pemerintahan daerah yang baik dan berwibawa. Standar baik dan kuat ini terletak terwujudnya suatu pemerintahan yang dapat menjalankan perintah peraturan perundang-undangan dengan sebaik-baiknya sesuai dengan kepentingan masyarakat di Kota Batu. Penyelenggaraan pemerinatahan daerah di Kota Batu identik dengan sejumlah pemerintahan daerah di Propinsi lain, yang sama-sama mengandalkan optimalisasi, efektifitas, dan profesionalitas kinerja dewan, sehingga apa yang diperankan oleh DPRD Kota Batu pun menentukan bangunan pemerintahan sekarang dan mendatang. Oleh karena itu, DPRD Kota Batu akan berusaha memaksimalisasikan peran yang sudah digariskan oleh norma yuridis.Kata kunci: dewan, peran, yuridis, kinerja, penyelenggaraan The Batu City DPRD tries its best to build good and authoritative regional government. This good and strong standard lies in the realization of a government that can best carry out the orders of laws and regulations in accordance with the interests of the people in Batu City. The implementation of regional government in Kota Batu is identical with a number of regional governments in other provinces, which both rely on the optimization, effectiveness and professionalism of the performance of the council, so that what is played by the Batu City DPRD determines the current and future government buildings. Therefore, the Batu City DPRD will try to maximize the role outlined by juridical norms.Keywords: board, role, juridical, performance, administration
PRO KONTRA KOMPARASI HUKUMAN MATI UNTUK PENGEDAR NARKOTIKA
Authors: Mardhani Candra Tri 
Published: June 2021

AbstrakPro kontra soal hukuman mati bagi pengedar narkotika adalah logis. elaksanaan hukuman mati terhadap pengedar narkoba atau tindak pidana pengedaran narkotika di sejumlah Negara juga mempunyai kesamaan dan perbedaan. Persamaannya, bahwa tidak setiap pengedar bisa dijatuhi hukuman mati. Hanya pengedar dengan jumlah tertentu yang bisa dijatuhi dengan sanksi hukuman mati. Mereka (masing-masing Negara) tetap dalam suatu kesepakatan untuk menjadikan pengedar narkoba sebagai ancaman serius bagi kelangsungan hidup bermasyarakat dan bernegara, khususnya dalam merusak dan menghancurkan generasi mudaKata kunci: narkotika, hukuman mati, pengedar AbstractThe pros and cons of the death penalty for narcotics dealers are logical. the implementation of the death penalty for drug dealers or criminal acts of drug trafficking in a number of countries also have similarities and differences. Similarly, not every dealer can be sentenced to death. Only dealers with a certain amount can be sentenced to death penalty. They (each country) remain in an agreement to make drug dealers a serious threat to the survival of society and the state, especially in destroying and destroying the younger generation Keywords: narcotics, death penalty, dealer
Sifat Organoleptik Bakso Pada Berbagai Rasio Perbandingan Daging Sapi Dan Babi
Authors: Hetharia Charliany , Loppies Yerrynaldo , Handu Herman 
Published: June 2021

Tujuan penelitian ini adalah untuk mengetahui rasio antara daging sapi dan daging babi yang disukai serta untuk mengetahui pengaruh rasio antara daging sapi dan daging babi terhadap sifat organoleptik bakso yang dihasilkan. Penelitian ini menggunakan rasio presentasi daging sapi dan daging babi yang berbeda yaitu Â P1 (75% daging sapi : 25% daging babi),Â Â P2 (50% daging sapi : 50% daging babi), P3 (25% daging sapi : 75% daging babi), K1 (kontrol bakso sapi) dan K2 (kontrol bakso babi) Â dan 35 panelis Â sebagai ulangan. Peubah yang diamati adalah sifat organoleptik berupa warna, aroma, tekstur, rasa dan kekenyalan. Data yang diperoleh dianalisa dengan metode Kruskal-Wallis.Hasil penelitian menunjukkan bahwa perlakuan rasio daging sapi dan daging babi berpengaruh nyata pada taraf (P<0,05) terhadap sifat organoleptik warna dan kekenyalan tetapi tidak berpengaruh terhadap sifat organoleptik aroma, rasa dan tekstur. Berdasarkan hasil tersebut maka dapat disimpulkan bahwa rasio antara daging sapi dan daging babi yang disukai serta memberikan pengaruh terhadap sifat organoleptik adalah P2 (50% daging sapi : 50% daging babi)
Well-Placed Acetabular Component Oriented Outside the Safe Zone During Weight-Bearing Daily Activities
Authors: Zheng Nan , Hu Xiangjun , Dimitriou Dimitris , Dai Kerong , Guo Tao , Tsai Tsung-Yuan 
Published: June 2021

Background:A comprehensive and thorough understanding of functional acetabular component orientation is essential for optimizing the clinical outcome after total hip arthroplasty (THA). This study aimed to quantify the functional acetabular anteversion and inclination of unilateral THA patients during walking and static standing and to determine whether the functional acetabular orientation falls within the Lewinnek safe zone.Methods:Seventeen patients with unilateral THA received a CT scan and dual fluoroscopic imaging during level walking and static standing to evaluatein vivohip kinematics. The pelvic functional coordinate system of the 3D CT-based computer model was defined by the line of gravity and anterior pelvic plane (APP) to measure functional acetabular anteversion and inclination in different postures. The Lewinnek safe zone was used to determine the acetabular malposition during functional activities.Results:The THA side demonstrated an average of 10.1° (± 9.6°, range –7.5° to 29.9°) larger functional anteversion and 16.0° (± 9.2°, range –7.2° to 29.9°) smaller inclination than native hips during level walking. Functional acetabular anteversion in the THA side during level walking and static standing was significantly larger than anatomical measurements (p&lt; 0.05). Acetabular orientation of most well-placed THA components anatomically in the Lewinnek safe zone fell outside the safe zone during more than half of the gait cycle and static standing.Conclusion:The current study revealed that an anatomically well-placed acetabular cup does not guarantee a well-functional orientation during daily activities. Thein vivomechanical performance and loading conditions of the THA component during other weight-bearing activities should be investigated in further studies.
miR-548d-3p Alters Parasite Growth and Inflammation in Leishmania (Viannia) braziliensis Infection
Authors: Souza Marina de Assis , Ramos-Sanchez Eduardo Milton , Muxel Sandra Márcia , Lagos Dimitris , Reis Luiza Campos , Pereira Valéria Rêgo Alves , Brito Maria Edileuza Felinto , Zampieri Ricardo Andrade , Kaye Paul Martin , Floeter-Winter Lucile Maria , Goto Hiro 
Published: June 2021

American Tegumentary Leishmaniasis (ATL) is an endemic disease in Latin America, mainly caused in Brazil byLeishmania (Viannia) braziliensis. Clinical manifestations vary from mild, localized cutaneous leishmaniasis (CL) to aggressive mucosal disease. The host immune response strongly determines the outcome of infection and pattern of disease. However, the pathogenesis of ATL is not well understood, and host microRNAs (miRNAs) may have a role in this context. In the present study, miRNAs were quantified using qPCR arrays in human monocytic THP-1 cells infectedin vitrowithL. (V.) braziliensispromastigotes and in plasma from patients with ATL, focusing on inflammatory response-specific miRNAs. Patients with active or self-healed cutaneous leishmaniasis patients, with confirmed parasitological or immunological diagnosis, were compared with healthy controls. Computational target prediction of significantly-altered miRNAs fromin vitro L. (V.) braziliensis-infected THP-1 cells revealed predicted targets involved in diverse pathways, including chemokine signaling, inflammatory, cellular proliferation, and tissue repair processes. In plasma, we observed distinct miRNA expression in patients with self-healed and active lesions compared with healthy controls. Some miRNAs dysregulated during THP-1in vitroinfection were also found in plasma from self-healed patients, including miR-548d-3p, which was upregulated in infected THP-1 cells and in plasma from self-healed patients. As miR-548d-3p was predicted to target the chemokine pathway and inflammation is a central to the pathogenesis of ATL, we evaluated the effect of transient transfection of a miR-548d-3p inhibitor onL. (V.) braziliensisinfected-THP-1 cells. Inhibition of miR-548d-3p reduced parasite growth early after infection and increased production of MCP1/CCL2, RANTES/CCL5, and IP10/CXCL10. In plasma of self-healed patients, MCP1/CCL2, RANTES/CCL5, and IL-8/CXCL8 concentrations were significantly decreased and MIG/CXCL9 and IP-10/CXCL10 increased compared to patients with active disease. These data suggest that by modulating miRNAs,L. (V.) braziliensismay interfere with chemokine production and hence the inflammatory processes underpinning lesion resolution. Our data suggest miR-548d-3p could be further evaluated as a prognostic marker for ATL and/or as a host-directed therapeutic target.
Rise of the Colorado Plateau: A Synthesis of Paleoelevation Constraints From the Region and a Path Forward Using Temperature-Based Elevation Proxies
Authors: Heitmann Emma O. , Hyland Ethan G. , Schoettle-Greene Philip , Brigham Cassandra A. P. , Huntington Katharine W. 
Published: June 2021

The Colorado Plateau’s complex landscape has motivated over a century of debate, key to which is understanding the timing and processes of surface uplift of the greater Colorado Plateau region, and its interactions with erosion, drainage reorganization, and landscape evolution. Here, we evaluate what is known about the surface uplift history from prior paleoelevation estimates from the region by synthesizing and evaluating estimates 1) in context inferred from geologic, geomorphic, and thermochronologic constraints, and 2) in light of recent isotopic and paleobotanical proxy method advancements. Altogether, existing data and estimates suggest that half-modern surface elevations were attained by the end of the Laramide orogeny (∼40 Ma), and near-modern surface elevations by the mid-Miocene (∼16 Ma). However, our analysis of paleoelevation proxy methods highlights the need to improve proxy estimates from carbonate and floral archives including the ∼6–16 Ma Bidahochi and ∼34 Ma Florissant Formations and explore understudied (with respect to paleoelevation) Laramide basin deposits to fill knowledge gaps. We argue that there are opportunities to leverage recent advancements in temperature-based paleoaltimetry to refine the surface uplift history; for instance, via systematic comparison of clumped isotope and paleobotanical thermometry methods applied to lacustrine carbonates that span the region in both space and time, and by use of paleoclimate model mediated lapse rates in paleoelevation reconstruction.
Omics in a Digital World: The Role of Bioinformatics in Providing New Insights Into Human Aging
Authors: Dato Serena , Crocco Paolina , Rambaldi Migliore Nicola , Lescai Francesco 
Published: June 2021

BackgroundAging is a complex phenotype influenced by a combination of genetic and environmental factors. Although many studies addressed its cellular and physiological age-related changes, the molecular causes of aging remain undetermined. Considering the biological complexity and heterogeneity of the aging process, it is now clear that full understanding of mechanisms underlying aging can only be achieved through the integration of different data types and sources, and with new computational methods capable to achieve such integration.Recent AdvancesIn this review, we show that an omics vision of the age-dependent changes occurring as the individual ages can provide researchers with new opportunities to understand the mechanisms of aging. Combining results from single-cell analysis with systems biology tools would allow building interaction networks and investigate how these networks are perturbed during aging and disease. The development of high-throughput technologies such as next-generation sequencing, proteomics, metabolomics, able to investigate different biological markers and to monitor them simultaneously during the aging process with high accuracy and specificity, represents a unique opportunity offered to biogerontologists today.Critical IssuesAlthough the capacity to produce big data drastically increased over the years, integration, interpretation and sharing of high-throughput data remain major challenges. In this paper we present a survey of the emerging omics approaches in aging research and provide a large collection of datasets and databases as a useful resource for the scientific community to identify causes of aging. We discuss their peculiarities, emphasizing the need for the development of methods focused on the integration of different data types.Future DirectionsWe critically review the contribution of bioinformatics into the omics of aging research, and we propose a few recommendations to boost collaborations and produce new insights. We believe that significant advancements can be achieved by following major developments in bioinformatics, investing in diversity, data sharing and community-driven portable bioinformatics methods. We also argue in favor of more engagement and participation, and we highlight the benefits of new collaborations along these lines. This review aims at being a useful resource for many researchers in the field, and a call for new partnerships in aging research.
Acute Urticaria in Inpatients Undergoing Non-emergent Coronary Angiography With Corticosteroid Prophylaxis: A Retrospective Study
Authors: Chen Bangtao , Yu Fubing , Chen WenChieh , Wang Yong , Hao Fei 
Published: June 2021

Background and Aims: Acute urticaria (AU) is the most frequently reported immediate hypersensitivity reaction in skin by administration of iodinated contrast media (ICM). We aimed to establish the pattern and identify the risk factors of AU among inpatients undergoing non-emergent coronary angiography (CAG) with prophylactic corticosteroids in China.Methods: Medical records of 19,326 adult inpatients undergoing non-emergent CAG with prophylactic methylprednisolone in 2013–2019 were retrospectively investigated. AU was identified within 1 h post-ICM administration, and diffuse involvement was defined when wheals occur in two or more body parts, including the back, abdomen, chest, and extremities. Age- and sex-matched inpatients (1:4) without AU were randomly selected for assessment of risk factors.Results: Approximately 0.8% of CAG inpatients had AU, including 101 diffuse and 64 limited form. The diffuse AU was more common in settings of non-diagnostic CAG, iohexol used, average ICM injection≥3 ml/min, recurrent CAG, and past history of immediate hypersensitivity to ICM. Inpatients with preexisting allergies, decreased evaluated glomerular filtration rate, and increased high sensitivity C reactive protein or neutrophil-to-lymphocyte ratio prior to CAG had a higher probability of AU (odds ratio &gt;1, P &lt; 0.05 for all variables). All AU inpatients complained of pruritus, and mild itching predominated. AU dissipated in several days under treatment of ebastine or levocetirizine 10 mg/daily, but ebastine showed superiority.Conclusions: ICM-induced AU is not uncommon in non-emergent CAG inpatients with prophylactic methylprednisolone. Preexisting allergies, renal dysfunction, and mild inflammation are high-risk factors, and antihistamine monotherapy is a favorable candidate for ICM-related AU.
Voxel-Based Morphometry of Cerebellar Lobules in Essential Tremor
Authors: Ågren Richard , Awad Amar , Blomstedt Patric , Fytagoridis Anders 
Published: June 2021

BackgroundThe extent of neurodegeneration underlying essential tremor (ET) remains a matter of debate. Despite various extents of cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity and included a limited number of patients. Novel automated pipelines allow detailed segmentation of cerebellar lobules based on structural MRI.ObjectiveTo compare the volumes of cerebellar lobules in ET patients with those in healthy controls (HCs) using an automated segmentation pipeline.MethodsStructural MRI scans of ET patients eligible for deep brain stimulation (n = 55) and of age-matched and gender-matched HCs (n = 55, from the IXI database) were segmented using the automated CEREbellum Segmentation pipeline. Lobule-specific volume differences between the ET and HC groups were evaluated using a general linear model corrected for multiple tests.ResultsTotal brain tissue volumes did not differ between the ET and HC groups. ET patients demonstrated reduced volumes of lobules I-II, left Crus II, left VIIB, and an increased volume of right X when compared with the HC group.ConclusionA large cohort of ET patients demonstrated subtle signs of decreased cerebellar lobule volumes. These findings oppose the hypothesis of localized atrophy in cerebellar motor areas in ET, but not the possibility of cerebellar pathophysiology in ET. Prospective investigations using alternative neuroimaging modalities may further elucidate the pathophysiology of ET and provide insights into diagnostic and therapeutic approaches.
Analysis of Prognostic Risk Factors Determining Poor Functional Recovery After Comprehensive Rehabilitation Including Motor-Imagery Brain-Computer Interface Training in Stroke Patients: A Prospective Study
Authors: Wu Qiong , Ge Yunxiang , Ma Di , Pang Xue , Cao Yingyu , Zhang Xiaofei , Pan Yu , Zhang Tong , Dou Weibei 
Published: June 2021

Objective: Upper limb (UL) motor function recovery, especially distal function, is one of the main goals of stroke rehabilitation as this function is important to perform activities of daily living (ADL). The efficacy of the motor-imagery brain-computer interface (MI-BCI) has been demonstrated in patients with stroke. Most patients with stroke receive comprehensive rehabilitation, including MI-BCI and routine training. However, most aspects of MI-BCI training for patients with subacute stroke are based on routine training. Risk factors for inadequate distal UL functional recovery in these patients remain unclear; therefore, it is more realistic to explore the prognostic factors of this comprehensive treatment based on clinical practice. The present study aims to investigate the independent risk factors that might lead to inadequate distal UL functional recovery in patients with stroke after comprehensive rehabilitation including MI-BCI (CRIMI-BCI).Methods: This prospective study recruited 82 patients with stroke who underwent CRIMI-BCI. Motor-imagery brain-computer interface training was performed for 60 min per day, 5 days per week for 4 weeks. The primary outcome was improvement of the wrist and hand dimensionality of Fugl-Meyer Assessment (δFMA-WH). According to the improvement score, the patients were classified into the efficient group (EG, δFMA-WH &gt; 2) and the inefficient group (IG, δFMA-WH ≤ 2). Binary logistic regression was used to analyze clinical and demographic data, including aphasia, spasticity of the affected hand [assessed by Modified Ashworth Scale (MAS-H)], initial UL function, age, gender, time since stroke (TSS), lesion hemisphere, and lesion location.Results: Seventy-three patients completed the study. After training, all patients showed significant improvement in FMA-UL (Z = 7.381, p = 0.000**), FMA-SE (Z = 7.336, p = 0.000**), and FMA-WH (Z = 6.568, p = 0.000**). There were 35 patients (47.9%) in the IG group and 38 patients (52.1%) in the EG group. Multivariate analysis revealed that presence of aphasia [odds ratio (OR) 4.617, 95% confidence interval (CI) 1.435–14.860; p &lt; 0.05], initial FMA-UL score ≤ 30 (OR 5.158, 95% CI 1.150–23.132; p &lt; 0.05), and MAS-H ≥ level I+ (OR 3.810, 95% CI 1.231–11.790; p &lt; 0.05) were the risk factors for inadequate distal UL functional recovery in patients with stroke after CRIMI-BCI.Conclusion: We concluded that CRIMI-BCI improved UL function in stroke patients with varying effectiveness. Inferior initial UL function, significant hand spasticity, and presence of aphasia were identified as independent risk factors for inadequate distal UL functional recovery in stroke patients after CRIMI-BCI.