bluuebunny/crossref_metadata_2025_split huggingface dataset:
MENOPAUSE AS A FACTOR OF ORAL HEALTH
Authors: Mazur Iryna , Tatarchuk Tetiana , Kosey N. V. , Zanko О. V. , Efimenko Olga 
Published: December 2021

General increase of longevity in Ukraine and around the world along with the increasing number of women over 50 necessitates implementation of comprehensive scientifically based programs aimed to improve health and quality of life of this part of population.
The aim of this review of international and Ukrainian studies was to investigate in depth hormone associated mechanisms of pathologic conditions formation in peri- and postmenopausal women.
Materials and methods. Studies on association of climacteric symptoms and symptoms of dental pathology were analyzed.
Results. Our literature review showed worse condition of dental health in menopausal women. The pres­ence of estrogen receptors in oral mucosa and salivary glands increases the risk of dental pathology when ovarian function diminishes. Gradual decrease of ovarian steroids in female body causes changes in oral microbiota and changes microbial landscape of periodontal pockets and effects local immunity. This causes increase of oral mucosa pathology such as glossodynia or burning mouth syndrome, lichen planus and angular cheilitis. It also causes the increase of periodontal diseases rate.
Conclusions. Cross-disciplinary interaction of dentists and gynecologists-endocrinologists will provide possibilities to discover more common causes and pathogenic mechanisms of periodontal diseases and oral mucosa in menopausal women. This will provide possibilities for the development of comprehensive approach to diagnosis, treatment and prophylaxis.
Melihat Peran Perantara dalam Kasus Penyebaran Video Non-Konsensual dengan Kerangka Contextual Integrity
Authors: Saraswati Idha 
Published: December 2021

Jumlah kasus kekerasan berbasis gender online atau KBGO selama masa pandemi dilaporkan meningkat. Penambahan jumlah pengguna internet serta kian masifnya tranformasi digital selama masa pandemi dipandang berkontribusi dalam peningkatan kasus KBGO tersebut. Kekerasan berbasis gender yang selama ini sudah marak terjadi di ranah offline menemukan ruang baru di dunia online sehingga kian mengancam keamanan, kesehatan dan keselamatan perempuan. Dalam kasus KBGO, dua pihak yang paling banyak dibicarakan adalah pelaku dan korban. Namun, pembicaraan tersebut melupakan pihak lain yang juga berpengaruh penting dalam terjadinya kekerasan, yakni platform digital yang menjadi wadah maupun memfasilitasi peristiwa kekerasan. Platform digital seperti media sosial tercatat menjadi salah satu medium terjadinya KBGO. Tulisan ini memaparkan peran platform digital sebagai perantara dalam kasus kekerasan, khususnya KBGO, dengan menerapkan kerangka contextual integrity yang diajukan Nissenbaum (2010) pada kasus penyebaran video intim non-konsensual yang menimpa GA dan GL. Tulisan ini menunjukkan bahwa melalui sistem dan kebijakan layanannya, pihak perantara turut berperan dalam mendorong terjadinya KBGO.
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The number of online gender based violence (OGBV) cases in Indonesia are reportedly increasing during the pandemic. The increasing number of internet users and the massive digital transformation during the pandemic has contributed to the escalation in OGBV cases. Gender-based violence has found a new space in the online world, thus threatening women’s security, health, and safety. In the OGBV case, the two parties that has been discussed the most were the perpetrators and the victims. However, the discussion forgot about the other party that also had an important influence, namely the digital platform. Digital platfarm like social media has become the medium for OGBV.This paper describes the role of the digital platform as an intermediary party for communication exchange in the cases of online violence, especially OGBV, by applying the contextual integrity framework proposed by Nissenbaum (2010) in the dissemination of non-consensual intimate videos of GA and GL cases. This paper shows that through its system and policies, digital platforms play significant role in facilitating OGBV.
Analisis Wacana Kritis Komentar Seksual dalam Media Sosial Twitter Laki-Laki Berekspresi Gender Feminin
Authors: Ayuningrum Nara Garini 
Published: December 2021

Pandemi COVID-19 memaksa masyarakat untuk mengisolasi diri mereka masing-masing demi mencegah penyebaran virus. Hal ini meningkatkan aktivitas daring para individu demi memenuhi segala kebutuhan dan kewajiban. Tidak hanya aplikasi berbasis jasa yang mengalami peningkatan aktivitas pengguna, tetapi juga aplikasi media sosial, salah satunya adalah Twitter. Dengan berbagai fitur yang ditawarkan, Twitter tidak hanya mempermudah individu untuk berkomunikasi dengan orang-orang yang dikenalnya, tetapi juga membuka peluang untuk berinteraksi dengan pengguna lain tanpa adanya batasan. Twitter memungkinkan penggunanya untuk mengunggah swafoto dan membiarkan pengguna lain untuk mengomentari swafoto/unggahan tersebut. Dalam penelitian ini, penulis akan menganalisis komentar-komentar bernada seksual yang ada pada swafoto akun @dododid_ selama periode tahun 2020. Dengan menggunakan metode analisis wacana kritis Norman Fairclough, peneliti menemukan 3 wacana besar terkait swafoto laki-laki berekspresi gender feminin, yaitu wacana cantik = perempuan, wacana objektifikasi dan stigma dan stereotipe. Melalui penelitian ini penulis juga menemukan bahwa kekerasan gender berbasis online bisa dialami oleh siapa saja dalam bentuk yang bermacam-macam.
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The COVID-19 forces people to isolate themselves to prevent the spread of the virus. COVID-19 increases the online activities of individuals to meet all their needs and obligations. Not only service-based applications that increased user activity, but also social media applications, which is Twitter. With the various features that Twitter offers, it not only makes it easier for individuals to communicate with people they know, but also opens up opportunities to interact with other users without any restrictions. Twitter allows its users to upload selfies and allows other users to comment on those selfies/uploads. In this research, authors analyzed sexually comments on @dododid_ selfies during the 2020 period. Using Norman Fairclough's critical discourse analysis method, authors found 3 major discourses related to selfies of men with feminine gender expression, that are beautiful discourse = women, objectification discourse and stigma and stereotypes. Through this study the author also found that online-based gender violence can be experienced by anyone in various forms.
Berebut Kuasa Tubuh: Norma Agama dan Kuasa Tubuh dalam Kekerasan Gender Berbasis Online
Authors: Imawan Rafif Pamenang 
Published: December 2021

Kajian ini akan mengeksplorasi kekerasan berbasis gender dengan mengeksplorasi pengaturan data pribadi dan solusi dominasi patriarki dalam masalah media online. Dengan menggunakan tinjauan pustaka sistematis, tujuan dari penelitian ini adalah memberikan peta kompleksitas dalam masalah pemanfaatan media sosial online. Harapan dari penelitian ini adalah dapat memberikan informasi kepada pembaca tentang masalah hakikat kekerasan berbasis gender online dengan memberikan peta permasalahan sosial di Indonesia. Selain itu, secara akademis, tulisan ini akan mengeksplorasi teori postmodernisme tentang gender, ruang media sosial dan online serta masalah pola pikir struktural terkait kekerasan berbasis gender. Dalam ranah yang lebih praktis, tulisan ini akan memberikan landasan dasar bagi para pemangku kepentingan untuk merumuskan kebijakan terkait kekerasan berbasis gender secara online.
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The COVID-19 forces people to isolate themselves to prevent the spread of the virus. COVID-19 increases the online activities of individuals to meet all their needs and obligations. Not only service-based applications that increased user activity, but also social media applications, which is Twitter. With the various features that Twitter offers, it not only makes it easier for individuals to communicate with people they know, but also opens up opportunities to interact with other users without any restrictions. Twitter allows its users to upload selfies and allows other users to comment on those selfies/uploads. In this research, authors analyzed sexually comments on @dododid_ selfies during the 2020 period. Using Norman Fairclough's critical discourse analysis method, authors found 3 major discourses related to selfies of men with feminine gender expression, that are beautiful discourse = women, objectification discourse and stigma and stereotypes. Through this study the author also found that online-based gender violence can be experienced by anyone in various forms.
ANTIHYPERLIPIDEMIC EFFECT OF THE ETHANOL EXTRACT FRACTION FROM MULBERRY (MORUS AUSTRALIS POIR.) LEAVES ON RATS INDUCED HIGH FAT-DIET (HFD) AND PROPYLTHIOURACIL (PTU)
Authors: TENDA PRISKA ERNESTINA , TOYO ELEONORA MARYETA , RAMADANI ARBA PRAMUNDITA 
Published: December 2021

Objectives: To evaluate the effect of extract and its fraction (n-hexane, ethyl acetate, and water) of the mulberry leaf (Morus australis Poir.) in reducing triglyceride and total cholesterol levels on HFD and PTU induced rats.
Methods: In this study, mulberry leaves were collected from East Nusa Tenggara-Indonesia, extracted using maceration method, and fractionated with various solvents. The thin layer chromatography with silica gel 60 F254 was utilized to identify the active compound on both extract and fraction. Furthermore, using a quasi-experimental with control group design, this study employed 40 healthy male Wistar rats and divided into 8 groups, namely: normal and negative control, positive controls (simvastatin and gemfibrozil), ethanolic extract, and fractions (n-hexane, ethyl acetate, and water). All groups were fed with a high cholesterol diet and 0.01% PTU, except for the normal group. During the study, the blood was drawn at day 0, 28, 35, and 42. The triglyceride level was observed using Glycerophosphate-Oxidase Phenol Aminoantipyrine (GPO-PAP) method, while the total cholesterol was measured by Cholesterol Oxidase Phenol Aminoantipyrine (CHOD-PAP).
Results: On the 42nd day, ethyl fraction of mulberry leaf (Morus australis Poir.) showed the most significant result of reducing the level of triglyceride and total cholesterol compared to the high-fat diet and PTU induced rat on day 0: triglyceride of 104.89±2.70 mg/dl vs 64.76±1.97 mg/dl and total cholesterol of 96.70±2.45 vs 88.02±1.38 mg/dl. Ethyl acetate fraction was similar to simvastatin in lowering the level of total cholesterol. TLC identification also showed that mulberry leaf contains flavonoids and polyphenols that act as anti-hyperlipidemic.
Conclusion: Ethyl acetate fraction of mulberry leaf (Morus australis Poir.) showed best activity on lowering both triglyceride and total cholesterol.
THE MOLECULAR INTERACTION AND ADMET PREDICTION OF MODIFIED JPH203 AS A POTENTIAL RADIOPHARMACEUTICAL KIT FOR MOLECULAR IMAGING OF CANCER: AN IN SILICO RESEARCH
Authors: HOLIK HOLIS ABDUL , IBRAHIM FAISAL MAULANA , WIANATALIE ELISHA , ACHMAD ARIFUDIN , FARIED AHMAD , KARTAMIHARDJA ACHMAD HUSSEIN SUNDAWA 
Published: December 2021

Objective: In this study, various types of pharmacokinetic modifying linkers and chelators are combined with JPH203 to obtain the best-docked molecule for prospective radiopharmaceutical kits.
Methods: AutoDock 4.2.6 and AutoDockTools 1.5.6 programs was used to do the molecular docking simulation and ADMET prediction was done using VNN-ADMET to predict the pharmacokinetics and toxicity of the ligand.
Results: The result of this study showed that JPH203-linker K-NOTA has the best affinity with a docking score of about-10.7 kcal/mol and shows hydrogen interaction with Tyr259, which acts as key residue of the active site.
Conclusion: Based on the results, JPH203-linker K-NOTA has good potential as a radiopharmaceutical kit of cancer.
DEVELOPMENT OF PAPER-BASED ANALYTICAL DEVICE FOR DETECTING DIAZEPAM IN URINE
Authors: PRATIWI RIMADANI , AMALIA NISA , HASANAH ALIYA NUR 
Published: December 2021

Objective: The aim of this study was to develop Paper-based Analytical Devices (PADs) with colorimetric method as a presumptive test for detecting diazepam in urine
Methods: Colorimetric method was used as a principle of this study. PADs were fabricated with wax-printing methods. Chosen colorimetric reagent was tested for selectivity with hydromorphone and codeine; and sensitivity by measuring the absorbance with UV-Vis spectrophotometer. PADs were tested for its sensitivity and stability. The intensity of color developed on PADs are measured with ImageJ. The ability of PADs to detect diazepam in urine was simulated with testing spiked urine sample to the PADs
Results: Zimmermann gave the most obvious prominent color change from colorless to purple-red color out of the four reagents. PAD is selective to diazepam when tested with hydromorphone and codeine. PAD is sensitive with a cut-off concentration at 100 ppm. PAD can detect diazepam in urine with the highest recovery percent at 92.8%±4,6
Conclusion: It can be concluded that PAD is quite selective and sensitive to detect diazepam in urine and can be done easily and fast for onsite analysis
IN SILICO STUDIES OF (S)-2-AMINO-4-(3,5-DICHLOROPHENYL) BUTANOIC ACID AGAINST LAT1 AS A RADIOTHERANOSTIC AGENT OF CANCER
Authors: HOLIK HOLIS ABDUL , IBRAHIM FAISAL MAULANA , FATAH ABIB LATIFU , ACHMAD ARIFUDIN , KARTAMIHARDJA ACHMAD HUSSEIN SUNDAWA 
Published: December 2021

Objective: This study aims to obtain a good activity of radiotheranostic kit for cancer which is built by combining (S)-2-amino-4-(3,5-dichlorophenyl) butanoic acid (ADPB) with various bifunctional chelators.
Methods: This study was conducted through in silico method that consists of molecular docking simulation using AutoDock 4 as well as ADMET prediction using vNN-ADMET and Pre-ADMET. Six bifunctional chelators (i.e. CTPA, DOTA, H2CB-TE2A, H2CB-DO2A, NOTA, and TETA) were conjugated with ADPB as a carrier molecule and further analyzed through molecular docking and ADMET prediction.
Results: The results showed that the ADPB-NOTA has the best affinity with the Gibbs free energy (ΔG) of-7.68 kcal/mol with an inhibition constant of 2.36 µM and its ability to bind with the gating residue of LAT1 (ASN258) through hydrogen interactions. Besides that, the ADPB-NOTA compound has a good ADME profile and is predicted to be safe for human use.
Conclusion: This study showed that ADPB-NOTA is the most prospective candidate to be used as a radiotheranostic agent.
Desarrollo de prototipo de un sistema de reconocimiento visual para determinar el grado de madurez de la de mauritia flexuosa en el departamento del Guaviare
Authors: Acosta Rodríguez Gustavo Adolfo , Hernández González Jesús Manuel , Figueroa Edgar Camilo , Salamanca Mahecha Daniel 
Published: December 2021

Realizar un prototipo de un Sistema de Reconocimiento Visual (SRV) que por medio de redes neuronales (inteligencia artificial) con acoplación de la caracterización del objeto a evaluar tendrá como funcionalidad la identificación de la madurez del fruto de la palma de moriche (Mauritia flexuosa) por medio de una imagen utilizando drones para los registros fotográficos de los racimos de la misma. Esto con el fin, primero, de minimizar la intervención humana en los humedales que son hábitats naturales de la palma para mantener el equilibrio en la fauna y flora propio de este ecosistema. Segundo, crear una alternativa económica legal y justa para las familias campesinas y comunidades indígenas del Municipio de San José del Guaviare.
Herramientas de ingeniería para el desarrollo de un software matemático
Authors: Hernández Molina Oscar Julián , Buitrago Tabares Bairo , Caamaño Cadavid Valeria 
Published: December 2021

En este Working Paper se explicará la manera como se implementaron las herramientas de la ingeniería del software con el desarrollo del software matemático, haciendo que este sistema sea lo suficientemente competente para ser implementado en la Institución Educativa Nuestra Señora del Carmen, cumpliendo los estándares de calidad apropiados y basados en las mallas curriculares del grado 5° de primaria del Ministerio de Educación Nacional.
Este sistema fue desarrollado con el fin de que los alumnos aprenda de una forma didáctica y práctica cada uno de los temas y resuelvan los ejercicios para el grado 5° de primaria, permitiendo realizar una medición de los datos de los estudiantes, la utilización de las TICs como herramientas de software y la trazabilidad mirando si con el sistema se logra la mejora continua con los alumnos.
La importancia de promover actividades de interacción en la producción lingüística de los aprendices del programa virtual English dot Works
Authors: Osorio Vélez Martha Isabel 
Published: December 2021

El propósito de este estudio fue conocer hasta qué punto las diferentes actividades interactivas realizadas en las tutorías sincrónicas generaron un impacto en el desarrollo de habilidades comunicativas elementales en los aprendices del segundo nivel del programa English Dot Works (EDW) del SENA. Siempre reconociendo un enfoque de aprendizaje combinado y basado en las tecnologías de información y comunicación. El estudio se realizó bajo una investigación cualitativa desarrollando un enfoque descriptivo cuasi experimental con un diagnóstico inicial, el cual dio cuenta del bajo nivel de los aprendices en la producci
El propósito de este estudio fue conocer hasta qué punto las diferentes actividades interactivas realizadas en las tutorías sincrónicas generaron un impacto en el desarrollo de habilidades comunicativas elementales en los aprendices del segundo nivel del programa English Dot Works (EDW) del SENA. Siempre reconociendo un enfoque de aprendizaje combinado y basado en las tecnologías de información y comunicación. El estudio se realizó bajo una investigación cualitativa desarrollando un enfoque descriptivo cuasi experimental con un diagnóstico inicial, el cual dio cuenta del bajo nivel de los aprendices en la producción del idioma inglés como lengua extranjera (EFL) debido a la falta de estrategias de interacción en el curso en línea siendo un obstáculo para alcanzar las metas esperadas del nivel. Se realizó una etapa de acción de tutorías adicionales en las que se implementó y evaluó la propuesta del desarrollo y producción del lenguaje en entornos de aprendizaje en línea. El objetivo principal de la intervención fue ayudar a los aprendices a comprender mejor las nociones y los temas que se estudian en el curso; así como la producción lingüística por medio de actividades que promuevan interacción entre aprendiz-tutor y aprendiz-aprendiz.
ón del idioma inglés como lengua extranjera (EFL) debido a la falta de estrategias de interacción en el curso en línea siendo un obstáculo para alcanzar las metas esperadas del nivel. Se realizó una etapa de acción de tutorías adicionales en las que se implementó y evaluó la propuesta del desarrollo y producción del lenguaje en entornos de aprendizaje en línea. El objetivo principal de la intervención fue ayudar a los aprendices a comprender mejor las nociones y los temas que se estudian en el curso; así como la producción lingüística por medio de actividades que promuevan interacción entre aprendiz-tutor y aprendiz-aprendiz.
INNOVATIVE APPROACHES TO THE FORMATION OF “SOFT SKILLS” IN THE PROFESSIONAL ACTIVITY OF SERVICE PROFESSIONALS
Authors: Shestel Olena , Starynets Olena , Danyliuk Alla 
Published: December 2021

The article analyzes the role of and approaches to the formation of “soft skills” in the studying and professional activities of service professionals.
The relevance of the proposed study lies in the lack of coverage in the scientific literature of the role of “soft skills”in the professional activities of service professionals. It should be noted that the role of “soft skills” in the process of performing professional tasks of specialists in various fields of knowledge is increasingly attracting the attention of scientists, primarily due to globalization, focus on European quality standards in services, and employers' requirements for employee’s not only professional but also social skills.
To achieve this goal it is necessary to perform the following tasks: to determine the pedagogical conditions for the formation of “soft” competencies in higher education in Tourism and Hospitality, which are extremely important for the daily professional activities of hospitality professionals, to analyze the prospects for “soft skills” actually in the process of professional activity, during professional internships, etc., as well as to analyze the current requirements of employers to the level of mastery of social skills.
Achieving this goal led to the use of the following research methods: systematization of modern scientific literature, theoretical analysis of scientific sources to determine the status and theoretical justification of the role of “soft skills” in the professional activities of service professionals. Methods of empirical research: observation, comparison, generalization.
It was proved that social skills play an important role in the professional activities of hospitality professionals, as the implementation of daily tasks is related to communication, including communication in foreign languages, teamwork, cooperation, stress, responsibility, etc. It should be noted that the analysis of labor market requirements revealed that employers are increasingly paying attention to the possession of future employees’ not only professional knowledge, skills and abilities, but “soft”competencies.
MODERN FORMS OF ORGANIZATION AND PROCESS OF ANIMATION SERVICE AT HOTEL ENTERPRISES
Authors: Tymchuk Svitlana , Tereshchuk Natalia 
Published: December 2021

The article considers the process of improving the quality of service in hospitality enterprises through animation activities. Animation is considered as a whole industry in hotel service, an integral part of the whole service and quality hotel service. The paper also outlines areas for improving service in hotel enterprises through the introduction of animation services to their activities.
The main purpose of this article is to analyze the factors influencing the development of animation services, to reveal the main functions and directions of animation services and to find possible innovations in the hotel industry animation programs, using the experience of leading hotel companies and foreign countries.
The problem of product quality assurance is very important now, because much in the development of a particular industry depends on how progressive its implementation is. However, speaking about the main indicators of quality, as well as possible problems that may arise with the release of quality services, they are individual for the hotel and restaurant business and the hospitality industry in general. Now a whole new direction has been actively used all over the world - animation, it occupies an important niche in the development of tourism in general, and is quite relevant for the effective functioning of hospitality enterprises. The organization of animation is the main part of the hotel business, which expresses its high degree of professionalism.
Considering the animation service in hotels, we can conclude that in today's world in conditions of fierce competition in the market of tourist services it is impossible to imagine a hotel complex without the organization of animation activities. In order for the guests of the hotel and restaurant business of different nationalities, different ages, wealth and opportunities (physical, intellectual, etc.) to remain satisfied, animation programs must be improved and changed throughout the season in content, intensity, time and other parameters for the return of visitors to the hotel.