bluuebunny/crossref_metadata_2025_split huggingface dataset:
RE-EVALUATING THE BRONZE AND EARLIEST IRON AGE IN LATVIA: CHANGES IN BURIAL TRADITIONS IN THE LIGHT OF 14C DATES
Authors: Legzdiņa Dardega , Vasks Andrejs , Plankājs Eduards , Zariņa Gunita 
Published: February 2021

ABSTRACTUntil recently, there was a lack of radiocarbon (14C) dates from the Bronze and Earliest Iron Age (1800–500–1 BC) burial sites in Latvia. The chronology of the sites was assessed on the basis of archaeological analogies with neighboring regions and typological studies of the rather meagre grave inventory. In order to establish a firm foundation for an absolute chronology of burial sites and to better understand changes in mortuary practices during the period, sequences of samples from various burial sites have been dated. In this paper we report 48 14C dates from 12 different sites and discuss them in the context of previously established archaeological chronologies. 14C reservoir effects are addressed: regarding FRE, stable isotope analysis is helpful; however, more data should be gathered in future research. In some cases, the new dates are in accord with previous chronologies, while in other cases some widely accepted assumptions may need to be revised. The new dates have proved false several previous assumptions about both the dates of individual graves and whole sites. Based on the 14C dates, we model the chronological spread of burial barrows in Latvia along waterways, the earliest examples appearing in coastal western Latvia.
The conservation research–practice gap: a case study of a threatened bird
Authors: Pérez-Granados Cristian , López-Iborra Germán M. 
Published: February 2021

AbstractConservation research is less often applied in practice than is desirable for the optimization of conservation outcomes. We evaluated this conservation research–practice gap for a threatened passerine, Dupont's lark Chersophilus duponti. We reviewed the literature and classified the conservation interventions proposed by scientists as regulation and legislation, monitoring and research, or management. We sent a questionnaire to managers responsible for species conservation, to gather information about the reasons for implementing, or not, each conservation intervention. We found 16 conservation interventions proposed in the literature, of which 13 (81.2%) had been applied by managers at least once. We found a disparity between the frequency of scientific recommendations and the actions implemented by managers: some measures with high scientific consensus were rarely adopted, whereas approaches less frequently proposed by scientists were more often implemented by managers. Regulatory and monitoring/research interventions were applied more often than management interventions, probably because of legal obligations. Management interventions were less frequently implemented, mainly because of time and budget limitations. There was a negative correlation between the number of interventions implemented and the population trend of the species in each region, which suggests that conservation interventions were more commonly implemented when the species was facing local extinction. Our results indicate a mismatch between science and practice for the conservation of Dupont's lark, the reasons for which seem to be diverse and include factors such as financial and time limitations, legal obstacles and managers' perception of extinction risk. An iterative dialogue needs to be initiated between scientists and managers to evaluate the efficacy of interventions implemented, and facilitate evidence-based conservation.
Comparative efficacy and acceptability of expressive writing treatments compared with psychotherapy, other writing treatments, and waiting list control for adult trauma survivors: a systematic review and network meta-analysis
Authors: Gerger Heike , Werner Christoph Patrick , Gaab Jens , Cuijpers Pim 
Published: February 2021

AbstractBackgroundExpressive writing about a traumatic event is promising in treating posttraumatic stress disorder (PTSD) symptoms in adult trauma survivors. To date, the comparative efficacy and acceptability of this approach is uncertain. Therefore, we aimed to examine the comparative efficacy and acceptability of expressive writing treatments.MethodsWe included 44 RCTs with 7724 participants contributing 54 direct comparisons between expressive writing (EW), enhanced writing (i.e. including additional therapist contact or individualized writing assignments; EW+), PTSD psychotherapies (PT), neutral writing (NW), and waiting-list control (WL).ResultsEW, EW+, PT, and NW were statistically significantly more efficacious than WL at the longest available follow-up, with SMDs (95% CI) of −0.78 (−1.10 to −0.46) for PT, −0.81 (−1.02 to −0.61) for EW+ , −0.43 (−0.65 to −0.21) for EW, and −0.37 (−0.61 to −0.14) for NW. We found small to moderate differences between the active treatments. At baseline mean PTSD severity was significantly lower in EW+ compared with WL. We found considerable heterogeneity and inconsistency and we found elevated risk of bias in at least one of the bias dimensions in all studies. When EW+-WL comparisons were excluded from the analyses EW+ was no longer superior compared with EW.ConclusionsThe summarized evidence confirms that writing treatments may contribute to improving PTSD symptoms in medium to long-term. Methodological issues in the available evidence hamper definite conclusions regarding the comparative efficacy and acceptability of writing treatments. Adequately sized comparative randomized controlled trials preferably including all four active treatment approaches, reporting long-term data, and including researchers with balanced preferences are needed.
Revisiting Security Council action on terrorism: New threats; (a lot of) new law; same old problems?
Authors: McKeever David 
Published: February 2021

AbstractThe devastating events of 9/11 triggered the adoption of Resolution 1373 (2001) by the UN Security Council, a contentious development which was much debated and was widely seen as presaging a new type of activity by the Security Council – legislating for all UN member states. And yet, in the counter-terrorism sphere at least, the Council’s legislative activity in the years following 9/11 was relatively modest. Both quantitatively and qualitatively, that activity has been far exceeded by the Council’s response to the emergence of ISIL in 2014. This more recent activity is of interest beyond the confines of counter-terrorism, but has received far less scrutiny to date. This article will remedy this gap, revisiting, in light of the recent activity, the relative merits and disadvantages of making counter-terrorism law through Security Council resolutions. It makes two main contentions. The first is that – due to some factors which were anticipated in the early 2000s and many which were not – Security Council resolutions on terrorism constitute a distinctive category of international law-making and pose serious challenges for the application of organizing principles and processes of general international law. The second is that, for these reasons as well as doubts as to the necessity and efficacy of recent action, making counter-terrorism law through Security Council resolutions should be the exception rather than the norm.
LV non-compaction in patients with coarctation of the aorta: prevalence and effects on cardiac function
Authors: Choudhary Preeti , Strugnell Wendy , Puranik Rajesh , Hamilton-Craig Christian , Kutty Shelby , Celermajer David S. 
Published: February 2021

AbstractBackground:Left ventricular non-compaction has been associated with heart failure, arrhythmia, thromboembolism and sudden death. The prevalence of non-compaction in patients with coarctation of the aorta and its clinical significance remains unknown, although obstructive left heart disease is common in patients with non-compaction. We sought to evaluate the prevalence of left ventricular non-compaction in patients with repaired aortic coarctation as well as its effect on left ventricular size and systolic function.Methods and results:In total, 268 patients (Mean age 26 (inter-quartile range 21–37) years, 63% male) undergoing cardiac magnetic resonance imaging for clinical follow-up were included from three tertiary centres for adult congenital heart disease. Clinical data was obtained from medical records and correlated with ventricular volumes and function. Left ventricular non-compaction was defined as a diastolic non-compacted:compacted dimension ratio >2.3 in the worst affected segment on a long-axis view. Left ventricular non-compaction was present in 8.2% of patients with repaired coarctation. Left ventricular end-diastolic volumes and stroke volumes were significantly higher in patients with non-compaction compared to those without. There were no significant differences in ventricular mass or ejection fraction in these two groups.Conclusions:Left ventricular non-compaction is relatively common in patients with repaired coarctation of the aorta and correlates with increased left ventricular end-diastolic volumes.
Early augmentation by using neuromodulation in psychiatric disorder: a kaleidoscopic view
Authors: Kar Sujita Kumar , Menon Vikas 
Published: February 2021

AbstractEarly augmentation is a relatively newer concept in the management of psychiatric disorders. In managing psychiatric disorders, augmentation strategies are commonly used after failed attempts of optimization of a dose of the medications and then switching to another medication. Neuromodulation methods are recommended by traditional treatment recommendations as augmenting strategies (mostly) in managing treatment-resistant/refractory cases of psychiatric disorders. Late in the process of therapy, several of these techniques are applied to the patient. However, using different neuromodulation techniques, early augmentation of the ongoing pharmacological or psychological treatment may be achieved, resulting in early symptom reduction or remission and early return to work by resuming functionality. The length of the symptomatic cycle may be shortened by early augmentation. There are several potential challenges to adopting an early augmentation strategy in clinical practice. This article discusses the concept and evidence of early augmentation strategy in managing psychiatric disorder by using neuromodulation technique and potential challenges before it.
Cyproheptadine: a psychopharmacological treasure trove?
Authors: Badr Bassem , Naguy Ahmed 
Published: February 2021

AbstractCyproheptadine has a unique pharmacologic portfolio that speaks to the idea of a pluripotent molecule beyond an antiallergic agent which can expand its therapeutic potential to address a multitude of psychiatric indications. Here, authors touch on the topic with focused literature review of extant evidence.
Review of biosensing with whispering-gallery mode lasers
Authors: Toropov Nikita , Cabello Gema , Serrano Mariana P. , Gutha Rithvik R. , Rafti Matías , Vollmer Frank 
Published: February 2021

AbstractLasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
Authors: Wang Bei , Wu Lujin , Chen Jing , Dong Lingli , Chen Chen , Wen Zheng , Hu Jiong , Fleming Ingrid , Wang Dao Wen 
Published: February 2021

AbstractThe arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid (diHETEs), eicosatetraenoic acids (ETEs), and lipoxins (LXs). Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases (CVD), cancers, and inflammatory diseases. This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2. Thus, we herein present a synopsis of AA metabolism in human health, cardiovascular and cancer biology, and the signaling pathways involved in these processes. To explore the role of the AA metabolism and potential therapies, we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions.
Ultra-processed food targets bone quality via endochondral ossification
Authors: Zaretsky Janna , Griess-Fishheimer Shelley , Carmi Adi , Travinsky Shmul Tamara , Ofer Lior , Sinai Tali , Penn Svetlana , Shahar Ron , Monsonego-Ornan Efrat 
Published: February 2021

AbstractUltra-processed foods have known negative implications for health; however, their effect on skeletal development has never been explored. Here, we show that young rats fed ultra-processed food rich in fat and sugar suffer from growth retardation due to lesions in their tibial growth plates. The bone mineral density decreases significantly, and the structural parameters of the bone deteriorate, presenting a sieve-like appearance in the cortices and poor trabecular parameters in long bones and vertebrae. This results in inferior mechanical performance of the entire bone with a high fracture risk. RNA sequence analysis of the growth plates demonstrated an imbalance in extracellular matrix formation and degradation and impairment of proliferation, differentiation and mineralization processes. Our findings highlight, for the first time, the severe impact of consuming ultra-processed foods on the growing skeleton. This pathology extends far beyond that explained by the known metabolic effects, highlighting bone as a new target for studies of modern diets.
CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129
Authors: Zhang Zhanqin , Zhu Hongtao , Hu Jianguo 
Published: February 2021

AbstractAt present, no systematic and in-depth study is available on the function and potential mechanisms of circular RNA in autophagy. This study aimed to screen the expression profiles of circRNA, miRNA, and mRNA of ovarian cancer cells induced by Torin 1 (10 µM). The expression profiles of circRNA, miRNA, and mRNA were analyzed with next-generation sequencing technology. CircRAB11FIP1 expression was elevated in epithelial ovarian cancer (EOC) tissues than in normal ovarian tissues. Silencing circRAB11FIP1 inhibited the autophagic flux of ovarian cancer SKOV3 cells. However, circRAB11FIP1 overexpression activated the autophagic flux of ovarian cancer A2780 cells. CircRAB11FIP1-induced autophagy accelerated EOC proliferation and invasion. Also, circRAB11FIP1 directly bound to miR-129 and regulated its targets ATG7 and ATG14. CircRAB11FIP1 bound to desmocollin 1to facilitate its interaction with ATG101. Also, circRAB11FIP1 directly bound to the mRNA of fat mass and obesity-associated protein and promoted its expression. Then, circRAB11FIP1 mediated mRNA expression levels of ATG5 and ATG7 depending on m6A. In general, this study demonstrated that circRAB11FIP1 regulated ATG7 and ATG14 by sponging miR-129. The data suggested that circRAB11FIP1 might serve as a candidate biomarker for EOC diagnosis and treatment.
Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling
Authors: Wang Yingyan , Lan Wen , Xu Mingxin , Song Jing , Mao Jun , Li Chunyan , Du Xiaohui , Jiang Yunling , Li Encheng , Zhang Rui , Wang Qi 
Published: February 2021

Abstract
Cancer-associated fibroblasts (CAFs) contribute to tumour epithelial-mesenchymal transition (EMT) via interaction with cancer cells. However, the molecular mechanisms underlying tumour-promoting EMT of CAFs in lung adenocarcinoma (ADC) remain unclear. Here, we observed that CAFs isolated from lung ADC promoted EMT via production of stromal cell-derived factor-1 (SDF-1) in conditioned medium (CM). CAF-derived SDF-1 enhanced invasiveness and EMT by upregulating CXCR4, β-catenin, and PPARδ, while downregulating these proteins reversed the effect. Furthermore, RNAi-mediated CXCR4 knockdown suppressed β-catenin and PPARδ expression, while β-catenin inhibition effectively downregulated PPARδ without affecting CXCR4; however, treatment with a PPARδ inhibitor did not inhibit CXCR4 or β-catenin expression. Additionally, pairwise analysis revealed that high expression of CXCR4, β-catenin, and PPARδ correlated positively with 75 human lung adenocarcinoma tissues, which was predictive of poor prognosis. Thus, targeting the CAF-derived, SDF-1-mediated CXCR4 β-catenin/ PPARδ cascade may serve as an effective targeted approach for lung cancer treatment.
Neuromodulation of the cerebellum rescues movement in a mouse model of ataxia
Authors: Miterko Lauren N. , Lin Tao , Zhou Joy , van der Heijden Meike E. , Beckinghausen Jaclyn , White Joshua J. , Sillitoe Roy V. 
Published: February 2021

AbstractDeep brain stimulation (DBS) relieves motor dysfunction in Parkinson’s disease, and other movement disorders. Here, we demonstrate the potential benefits of DBS in a model of ataxia by targeting the cerebellum, a major motor center in the brain. We use the Car8 mouse model of hereditary ataxia to test the potential of using cerebellar nuclei DBS plus physical activity to restore movement. While low-frequency cerebellar DBS alone improves Car8 mobility and muscle function, adding skilled exercise to the treatment regimen additionally rescues limb coordination and stepping. Importantly, the gains persist in the absence of further stimulation. Because DBS promotes the most dramatic improvements in mice with early-stage ataxia, we postulated that cerebellar circuit function affects stimulation efficacy. Indeed, genetically eliminating Purkinje cell neurotransmission blocked the ability of DBS to reduce ataxia. These findings may be valuable in devising future DBS strategies.
Layer number dependent ferroelasticity in 2D Ruddlesden–Popper organic-inorganic hybrid perovskites
Authors: Xiao Xun , Zhou Jian , Song Kepeng , Zhao Jingjing , Zhou Yu , Rudd Peter Neil , Han Yu , Li Ju , Huang Jinsong 
Published: February 2021

AbstractFerroelasticity represents material domains possessing spontaneous strain that can be switched by external stress. Three-dimensional perovskites like methylammonium lead iodide are determined to be ferroelastic. Layered perovskites have been applied in optoelectronic devices with outstanding performance. However, the understanding of lattice strain and ferroelasticity in layered perovskites is still lacking. Here, using the in-situ observation of switching domains in layered perovskite single crystals under external strain, we discover the evidence of ferroelasticity in layered perovskites with layer number more than one, while the perovskites with single octahedra layer do not show ferroelasticity. Density functional theory calculation shows that ferroelasticity in layered perovskites originates from the distortion of inorganic octahedra resulting from the rotation of aspherical methylammonium cations. The absence of methylammonium cations in single layer perovskite accounts for the lack of ferroelasticity. These ferroelastic domains do not induce non-radiative recombination or reduce the photoluminescence quantum yield.
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
Authors: Zheng Fang , Chen Jianing , Zhang Xiaoqian , Wang Zifeng , Chen Jiewen , Lin Xiaorong , Huang Hongyan , Fu Wenkui , Liang Jing , Wu Wei , Li Bo , Yao Herui , Hu Hai , Song Erwei 
Published: February 2021

AbstractHypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to pyruvate kinase 2 (PKM2) to induce its prolyl hydroxylation and introduces the PKM2/PHD3 complex into the nucleus via binding with heterogeneous nuclear ribonucleoprotein F (hnRNPF) to enhance HIF-1α transactivation. Reciprocally, HIF-1α induces HIFAL transcription, which forms a positive feed-forward loop to maintain the transactivation activity of HIF-1α. Clinically, high HIFAL expression is associated with aggressive breast cancer phenotype and poor patient outcome. Furthermore, HIFAL overexpression promotes tumor growth in vivo, while targeting both HIFAL and HIF-1α significantly reduces their effect on cancer growth. Overall, our results indicate a critical regulatory role of HIFAL in HIF-1α-driven transactivation and glycolysis, identifying HIFAL as a therapeutic target for cancer treatment.
Complex plasmon-exciton dynamics revealed through quantum dot light emission in a nanocavity
Authors: Gupta Satyendra Nath , Bitton Ora , Neuman Tomas , Esteban Ruben , Chuntonov Lev , Aizpurua Javier , Haran Gilad 
Published: February 2021

AbstractPlasmonic cavities can confine electromagnetic radiation to deep sub-wavelength regimes. This facilitates strong coupling phenomena to be observed at the limit of individual quantum emitters. Here, we report an extensive set of measurements of plasmonic cavities hosting one to a few semiconductor quantum dots. Scattering spectra show Rabi splitting, demonstrating that these devices are close to the strong coupling regime. Using Hanbury Brown and Twiss interferometry, we observe non-classical emission, allowing us to directly determine the number of emitters in each device. Surprising features in photoluminescence spectra point to the contribution of multiple excited states. Using model simulations based on an extended Jaynes-Cummings Hamiltonian, we find that the involvement of a dark state of the quantum dots explains the experimental findings. The coupling of quantum emitters to plasmonic cavities thus exposes complex relaxation pathways and emerges as an unconventional means to control dynamics of quantum states.