bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysfunction of calcium regulating system in comorbidity of peptic ulcer disease and osteoporosis and its correction
Authors: Fomina L. A. , Chernin V. V. , Fomina M. P. 
Published: January 2021

The comorbidity of various diseases requires the use of drugs that affect common etiological and pathogenetic aspects, which reduces polypharmacy and the risk of side-effect.Purpose of the study.Find out the state of calcium regulating system, calcium-phosphorus balance in the comorbidity of ulcer disease (UD) with osteoporosis (OP), and the effect of their shifts on the acid secretion and regional microcirculation. To determine the effectiveness of bisphosphonates in the complex treatment of these pathologies.Materials and methods.We examined 77 people with recurrent UD, 10 of whom revealed its comorbidity with OP. All patients underwent clinical and endoscopic studies, pH-metry, X-ray densitometry. The levels of parathyroid hormone, calcitonin, calcium and phosphorus in the blood were studiedResults.Recurrent of ulcer was characterized by a increase in para- thyroid hormone and calcium, a decrease in blood phosphorus. These changes were more pronounced in patients with a comorbidity of UD with OP and were accompanied by an increase in acid secretion and regional microcirculation. The use of etidronic acid in the treatment UD was characterized by a positive clinical result, normalization of secretion and regional microcirculation.Conclusion.The comorbidity of UD with OP is accompanied by functional changes in calcium regulating system. Correction of these changes with the use of bisphosphonates in the treatment of relapse of ulcer demonstrates clinical efficacy.
A LASSO-Derived Risk Model for Subclinical CAC Progression in Asian Population With an Initial Score of Zero
Authors: Wu Yun-Ju , Mar Guang-Yuan , Wu Ming-Ting , Wu Fu-Zong 
Published: January 2021

Background: This study is aimed at developing a prediction nomogram for subclinical coronary atherosclerosis in an Asian population with baseline zero score, and to compare its discriminatory ability with Framingham risk score (FRS) and atherosclerotic cardiovascular disease (ASCVD) models.Methods: Clinical characteristics, physical examination, and laboratory profiles of 830 subjects were retrospectively reviewed. Subclinical coronary atherosclerosis in term of Coronary artery calcification (CAC) progression was the primary endpoint. A nomogram was established based on a least absolute shrinkage and selection operator (LASSO)-derived logistic model. The discrimination and calibration ability of this nomogram was evaluated by Hosmer–Lemeshow test and calibration curves in the training and validation cohort.Results: Of the 830 subjects with baseline zero score with the average follow-up period of 4.55 ± 2.42 year in the study, these subjects were randomly placed into the training set or validation set at a ratio of 2.8:1. These study results showed in the 612 subjects with baseline zero score, 145 (23.69%) subjects developed CAC progression in the training cohort (N = 612), while in the validation cohort (N = 218), 51 (23.39%) subjects developed CAC progression. This LASSO-derived nomogram included the following 10 predictors: “sex,” age,” “hypertension,” “smoking habit,” “Gamma-Glutamyl Transferase (GGT),” “C-reactive protein (CRP),” “high-density lipoprotein cholesterol (HDL-C),” “cholesterol,” “waist circumference,” and “follow-up period.” Compared with the FRS and ASCVD models, this LASSO-derived nomogram had higher diagnostic performance and lower Akaike information criterion (AIC) and Bayesian information criterion (BIC) value. The discriminative ability, as determined by the area under receiver operating characteristic curve was 0.780 (95% confidence interval: 0.731–0.829) in the training cohort and 0.836 (95% confidence interval: 0.761–0.911) in the validation cohort. Moreover, satisfactory calibration was confirmed by Hosmer–Lemeshow test with P-values of 0.654 and 0.979 in the training cohort and validation cohort.Conclusions: This validated nomogram provided a useful predictive value for subclinical coronary atherosclerosis in subjects with baseline zero score, and could provide clinicians and patients with the primary preventive strategies timely in individual-based preventive cardiology.
A Thirty-Month Seafloor Test of the A-0-A Method for Calibrating Pressure Gauges
Authors: Wilcock William S. D. , Manalang Dana A. , Fredrickson Erik K. , Harrington Michael J. , Cram Geoff , Tilley James , Burnett Justin , Martin Derek , Kobayashi Taro , Paros Jerome M. 
Published: January 2021

Geodetic observations in the oceans are important for understanding plate tectonics, earthquake cycles and volcanic processes. One approach to seafloor geodesy is the use of seafloor pressure gauges to sense vertical changes in the elevation of the seafloor after correcting for variations in the weight of the overlying oceans and atmosphere. A challenge of using pressure gauges is the tendency for the sensors to drift. The A-0-A method is a new approach for correcting drift. A valve is used to periodically switch, for a short time, the measured pressure from the external ocean to the inside of the instrument housing at atmospheric pressure. The internal pressure reading is compared to an accurate barometer to measure the drift which is assumed to be the same at low and high pressures. We describe a 30-months test of the A-0-A method at 900 m depth on the MARS cabled observatory in Monterey Bay using an instrument that includes two A-0-A calibrated pressure gauges and a three-component accelerometer. Prior to the calibrations, the two pressure sensors drift by 6 and 2 hPa, respectively. After the calibrations, the offsets of the corrected pressure sensors are consistent with each other to within 0.2 hPa. The drift corrected detided external pressure measurements show a 0.5 hPa/yr trend of increasing pressures during the experiment. The measurements are corrected for instrument subsidence based on the changes in tilt measured by the accelerometer, but the trend may include a component of subsidence that did not affect tilt. However, the observed trend of increasing pressure, closely matches that calculated from satellite altimetry and repeat conductivity, temperature and depth casts at a nearby location, and increasing pressures are consistent with the trend expected for the El Niño Southern Oscillation. We infer that the A-0-A drift corrections are accurate to better than one part in 105 per year. Additional long-term tests and comparisons with oceanographic observations and other methods for drift correction will be required to understand if the accuracy the A-0-A drift corrections matches the observed one part in 106 per year consistency between the two pressure sensors.
Case Report: Late-Onset Congenital Adrenal Hyperplasia and Acute Covid-19 Infection in a Pregnant Woman: Multidisciplinary Management
Authors: Giavoli Claudia , Iurlaro Enrico , Morelli Valentina , Rodari Giulia , Ronchi Andrea , Pietrasanta Carlo , Pugni Lorenza , Tubiolo Daniela , Properzi Paolo , Pesenti Antonio , Mantovani Giovanna , Ferrazzi Enrico , Arosio Maura 
Published: January 2021

BackgroundThe impact of the Covid-19 infection on patients with chronic endocrine disease is not fully known. We describe here the first case of a pregnant woman with Covid-19 acute infection and non-classical congenital adrenal hyperplasia (NCAH).Case descriptionA woman at 36 weeks of gestation was referred to our Maternity Hospital for premature rupture of membranes (PROM). Her medical history was positive for NCAH on chronic steroid replacement till the age of 17 years (cortisone acetate and dexamethasone, both in the morning). At admission, her naso-oro-pharyngeal swab resulted positive for SARS-CoV-2. Due to hyperpyrexia and late preterm PROM, cesarean section was planned, and she was started on a 100 mg-bolus of hydrocortisone, followed by continuous infusion of 200 mg/24 h. A female neonate in good clinical condition and with a negative nasopharyngeal Covid-19 swab was delivered. On secondpostpartumday, the mother was in good condition and was switched to oral steroid therapy. On thirdpostpartumday she worsened, with radiological signs of acute pulmonary embolism. Oro-tracheal intubation and mechanical ventilation were started, and she was switched back to intravenous steroid therapy. On April 30, pulmonary embolism was resolved, and on May 13th she was discharged in good condition.ConclusionsWe report the first case of Covid-19 acute infection that occurred in late-pregnancy in a woman with NCAH on chronic steroid replacement. The management of the patient in a reference center with early involvement of a multidisciplinary team granted prompt care and adequate protection for all the involved sanitary operators.
Sodium Glucose Cotransporter 2 Inhibitors Reduce the Risk of Heart Failure Hospitalization in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Zhang Ailing , Luo Xufei , Meng Haiyang , Kang Jian , Qin Guijun , Chen Yaolong , Zhang Xiaojian 
Published: January 2021

AimTo evaluate the impact of sodium glucose cotransporter 2 inhibitors (SGLT-2i) on risk of heart failure hospitalization in patients with type 2 diabetes.MethodsWe searched the PubMed, Embase, The Cochrane Library, CNKI, Wanfang, CBM, and other web knowledge databases for data from randomized controlled trials. We performed statistical analyses by using review Manager (RevMan) 5.3 and STATA 12.0 for meta-analysis.ResultsEight randomized controlled trials that compared SGLT-2i versus placebo met our inclusion criteria and were included in the study. The final meta-analysis included a total of 55,763 type 2 diabetes patients. Compared with placebo, SGLT-2i reduced the risk of heart failure hospitalization (RR, 0.63; 95% CI, 0.53 to 0.74; P &lt; 0.00001), MACE (defined as cardiovascular death, myocardial infarction, or ischemic stroke) (RR, 0.92; 95% CI, 0.86 to 0.98; P &lt; 0.007), cardiovascular death (RR, 0.78; 95%CI, 0.62 to 0.99; P = 0.04) in type 2 diabetes patients. SGLT-2i could reduce the risk of death from any cause (RR, 0.77; 95% CI, 0.59 to 1.01; P = 0.06) without statistical significance in type 2 diabetes patients.ConclusionCompared with placebo, SGLT-2i may reduce the risk of heart failure hospitalization, MACE, and cardiovascular death. Therefore, SGLT-2i may be an ideal choice for type 2 diabetes mellitus patient with heart failure. These results will help inform practitioners, patients, and authorities making appropriate choices in hypoglycemic therapy clinical practice.
Integrated WGCNA and PPI Network to Screen Hub Genes Signatures for Infantile Hemangioma
Authors: Xu Miao , Ouyang Tianxiang , Lv Kaiyang , Ma Xiaorong 
Published: January 2021

BackgroundInfantile hemangioma (IH) is characterized by proliferation and regression.MethodsBased on the GSE127487 dataset, the differentially expressed genes (DEGs) between 6, 12, or 24 months and normal samples were screened, respectively. STEM software was used to screen the continued up-regulated or down-regulated in common genes. The modules were assessed by weighted gene co-expression network analysis (WGCNA). The enrichment analysis was performed to identified the biological function of important module genes. The area under curve (AUC) value and protein-protein interaction (PPI) network were used to identify hub genes. The differential expression of hub genes in IH and normal tissues was detected by qPCR.ResultsThere were 5,785, 4,712, and 2,149 DEGs between 6, 12, and 24 months and normal tissues. We found 1,218 DEGs were up-regulated or down-regulated expression simultaneously in common genes. They were identified as 10 co-expression modules. Module 3 and module 4 were positively or negatively correlated with the development of IH, respectively. These two module genes were significantly involved in immunity, cell cycle arrest and mTOR signaling pathway. The two module genes with AUC greater than 0.8 at different stages of IH were put into PPI network, and five genes with the highest degree were identified as hub genes. The differential expression of these genes was also verified by qRTPCR.ConclusionFive hub genes may distinguish for proliferative and regressive IH lesions. The WGCNA and PPI network analyses may help to clarify the molecular mechanism of IH at different stages.
Cognitive Behavioural Therapy and Light Dark Therapy for Maternal Postpartum Insomnia Symptoms: Protocol of a Parallel-Group Randomised Controlled Efficacy Trial
Authors: Verma Sumedha , Rajaratnam Shantha M. W. , Davey Margot , Wiley Joshua F. , Bei Bei 
Published: January 2021

Background: Symptoms of insomnia are common in new mothers and have been associated with a range of negative maternal and child outcomes. Despite this, interventions to improve maternal postpartum sleep remain scarce. Cognitive Behavioural Therapy (CBT) and Light Dark Therapy (LDT) represent two promising interventions for insomnia symptoms and associated daytime consequences such as fatigue. This randomised controlled trial examines whether CBT and LDT improve maternal insomnia symptoms as the primary outcome and maternal sleep disturbance, mood, fatigue, and sleepiness as secondary outcomes. This protocol paper outlines the development, design, and implementation of the trial.Methods: Participants are an Australian community-sample of 90 first-time mothers who are 4–12 months postpartum with self-reported symptoms of insomnia (Insomnia Severity Index scores ≥ 8). Exclusion criteria include current severe sleep/psychiatric disorders, unsettled infant sleep behaviour, sleep-affecting medication use, and photosensitivity. Eligible women are randomised into a CBT (strategies targeting sleep, worries, fatigue, and relaxation), LDT, or a treatment-as-usual control condition. Interventions are therapist-assisted and personalised through two telephone calls and include a series of automated intervention emails delivered over 6 weeks. Primary and secondary outcomes are assessed at four time points: baseline, intervention mid-point, post-intervention, and 1-month post-intervention.Discussion: If found effective, these interventions could represent efficacious, safe, and inexpensive treatments for improving postpartum insomnia and mitigate its negative impact on maternal well-being. Interventions tested are highly scalable and can be integrated into postpartum care and made available to the broader community.ANZCTR trial registration: Accessible at: https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12618000842268.
A Systematic Review With Network Meta-Analysis of the Available Biologic Therapies for Psoriatic Disease Domains
Authors: Torres Tiago , Barcelos Anabela , Filipe Paulo , Fonseca João Eurico 
Published: January 2021

Introduction:Several new treatments have been developed for psoriatic disease, an inflammatory condition that involves skin and joints. Notwithstanding, few studies have made direct comparisons between treatments and therefore it is difficult to select the ideal treatment for an individual patient. The aim of this systematic review with network meta-analysis (NMA) was to analyze available and approved biologic therapies for each domain of psoriatic disease: skin, peripheral arthritis, axial arthritis, enthesitis, dactylitis, and nail involvement.Methods:Data from randomized clinical trials (RCTs) were included. A systematic review was performed using the MEDLINE database (July 2020) using PICO criteria. Bayesian NMA was conducted to compare the clinical efficacy of biological therapy in terms of the American College of Rheumatology criteria (ACR, 24 weeks) and Psoriasis Area and Severity Index (PASI, 10–16 weeks).Results:Fifty-four RCTs were included in the systematic review. Due to the design of the RCTs, namely, outcomes and time points, network meta-analysis was performed for skin and peripheral arthritis domains. For the skin domain, 30 studies reporting PASI100 were included. The peripheral arthritis domain was analyzed through ACR70 in 12 studies. From the therapies approved for both domains, secukinumab and ixekizumab were the ones with the highest probability of reaching the proposed outcomes. There is a lack of outcome uniformization in the dactylitis, enthesitis, and nail domains, and therefore, an objective comparison of the studies was not feasible. Nevertheless, secukinumab was the treatment with the best compromise between the number of studies in each domain and the results obtained in the different outcomes.Conclusion:Secukinumab and ixekizumab were the treatments with the highest probability of reaching both PASI100 and ACR70 outcomes. Due to the lack of a standard evaluation of outcomes of the other psoriatic disease domains, a network meta-analysis for all the domains was not possible to perform.
Anharmonic Vibrational Frequencies and Spectroscopic Constants for the Detection of Ethynol in Space
Authors: Dallas Jax D. , Westbrook Brent R. , Fortenberry Ryan C. 
Published: January 2021

The ethynol (HCCOH) molecule has recently been shown to be present in simulated astrochemical ices possibly linking it to molecular building blocks for interstellar complex organic molecules like amino acids. The proposed reaction mechanism suggests the simultaneous formation of both ketene and ethynol from mixed carbon monoxide/water ice in simulated interstellar conditions. Rigorous anharmonic spectral data within both the IR and microwave regions are needed for possible detection of ethynol in the interstellar medium. This study provides the first such data for this molecule from high-level quantum chemical computations where experiment is currently lacking. Ethynol has aBeffcomparable to, but distinct from acetonitrile at 9,652.1 MHz and three notable infrared features with two in the hydride stretching-regions and the C–C stretch at 2,212.8 cm−1. The ketene isomer has already been detected in the interstellar medium, and the possible detection of ethynol made possible by this work may lead to a deeper understanding of the proposed ice formation mechanism involving both species and how this relates to the molecular origins of life.
The Relationship and Interaction Between Industry 4.0 and Education
Authors: Beke Éva 
Published: January 2021

Abstract
The effects and results of Industry 4.0 are ubiquitous: in mobile applications and laptops, in sensor-driven technologies, in communication capabilities, in intelligent robots, in smart offices and in cyberspace. In the future, the most sought after skills will not only be technology-related, but there will be a huge demand for creativity, emotional intelligence, critical thinking, and interpersonal skills.
Based on this knowledge, a whole new economic model and a change to the old system will be needed.
Reconstruction of a Grinding Machine Intended for Thermo-Polymers, and Design of a Linux Based Iot Control System
Authors: Debreceni Attila , Erdei Timotei István , Tóth Szabolcs , Husi Géza 
Published: January 2021

AbstractWith the increasing use of 3D printing technology, a closely related problem is that of spreading. This problem is the presence of the polymer waste created by faulty prints, and support material used during printing. To create filament from this waste, it must first be chopped into fine pieces. In this project, an original polymer grinder was designed and built, adopting the innovations of Industry 4.0. Remote control and supervision were achieved using a Raspberry Pi I. type B and an Arduino Nano. The finished project can be seen in the faculty of engineering at the University of Debrecen.
Does Whom Patients Sit Next to during Hemodialysis Affect Whether They Request a Living Donation?
Authors: Gillespie Avrum , Fink Edward L. , Gardiner Heather M. , Gadegbeku Crystal A. , Reese Peter P. , Obradovic Zoran 
Published: January 2021

Background
The seating arrangement of in-center hemodialysis is conducive to patients forming a relationship and a social network. We examined how seating in the in-center hemodialysis clinic affected patients forming relationships, whether patients formed relationships with others who have similar transplant behaviors (homophily), and whether these relationships influenced patients (social contagion) to request a living donation from family and friends outside of the clinic.

Methods
In this 30-month, prospective cohort study, we observed the relationships of 46 patients on hemodialysis in a hemodialysis clinic. Repeated participant surveys assessed in-center transplant discussions and living-donor requests. A separable temporal exponential random graph model estimated how seating, demographics, in-center transplant discussions, and living-donor requests affected relationship formation via sociality and homophily. We examined whether donation requests spread via social contagion using a susceptibility-infected model.

Results
For every seat apart, the odds of participants forming a relationship decreased (OR, 0.74; 95% CI, 0.61 to 0.90; P=0.002). Those who requested a living donation tended to form relationships more than those who did not (sociality, OR, 1.6; 95% CI, 1.02 to 2.6; P=0.04). Participants who discussed transplantation in the center were more likely to form a relationship with another participant who discussed transplantation than with someone who did not discuss transplantation (homophily, OR, 1.9; 95% CI, 1.03 to 3.5; P=0.04). Five of the 36 susceptible participants made a request after forming a relationship with another patient.

Conclusions
Participants formed relationships with those they sat next to and had similar transplant behaviors. The observed increase in in-center transplant discussions and living-donation requests by the members of the hemodialysis-clinic social network was not because of social contagion. Instead, participants who requested a living donation were more social, formed more relationships within the clinic, and discussed transplantation with each other as a function of health-behavior homophily.
Análisis de la percepción de los docentes estudiantes sobre el sistema de articulación del currículo integrado (SACI) implementado por el programa de Lic. en lenguas extranjeras con énfasis en inglés de la UCEVA
Authors: Giraldo Arcila Fabio Nelson , Rios Quintero Karina 
Published: January 2021

La Facultad de Ciencias de la Educación de Uceva ha venido implementando una estrategia de articulación que busca que los estudiantes planteen una propuesta alrededor de una pregunta integradora con la confluencia de todas las asignaturas, generado espacios de diálogo entre los diversos saberes y acercándose al propósito de articulación. Esta dinámica ha posibilitado contar con un Sistema de articulación que permite el diseño, implementación y evaluación de dicha articulación. Con el fin de fortalecer este proceso, el presente proyecto de investigación buscó conocer la percepción de los estudiantes y maestros sobre el sistema de articulación del currículo integrado (SACI), implementado por el Programa de Lic. en Lenguas Extranjeras con Énfasis en Inglés de la Uceva con el fin de conocer los posibles ajustes que requieren los instrumentos constituyéndose así en un insumo para un proceso de restructuración del mismo. Para este fin, se empleó un método mixto que involucró la recolección, análisis y la mezcla de los enfoques cuantitativo y cualitativo en un mismo estudio, lo que permitió una mejor y más completa comprensión de la percepción sobre el Sistema de articulación. Los resultados mostraron una percepción acertada tanto de docentes y estudiantes hacia la metodología y diseño del SACI, no obstante, de ellos parte la necesidad de realizar ajustes en cuanto a su implementación. Finalmente, se concluye que el diseño e implementación del SACI ha dado un aporte significativo al proceso de enseñanza- aprendizaje tanto para docentes y estudiantes y, así mismo, toda vez que se realicen los ajustes pertinentes se verán resultados eficientes.