bluuebunny/crossref_metadata_2025_split huggingface dataset:
SPECIAL FEATURES OF HYPERTENSION IN CHRONIC RENAL DISEASE: WHAT WE LEARN FROM AMBULATORY BLOOD PRESSURE MEASUREMENT
Authors: Zahidi Hatim Amine , Anass Maaroufi , Mehdi Aqli , Hajar Bendahou , Imad Nouamou , Sali Arous , Ghali Bennouna , Drighil Abdenacer , Leila Azzouzi , Habbal Rachida 
Published: April 2021

Objective:
High blood pressure (hypertension) is frequently encountered in chronic kidney disease (CKD). Whether responsible for CKD or secondary, hypertension constitutes an important and modifiable risk factor in the course of CKD. The appropriate assessment of BP in CKD therefore becomes crucial to establish the diagnosis of hypertension and to consider appropriate therapies. Recent studies including ambulatory blood pressure measurement (ABPM) in CKD rather than office measurement allows early diagnosis of hypertension and identification of high risk patients

Design and method:
This is a prospective study carried out within the explorations unit, the objective of which was to assess the contribution of MAPA, its peculiarities and its prognostic elements in MRC. The study included two groups of hypertensive patients: a group of patients with stage 3, 4 and 5 CKD and a control group. CKD was defined according to the KDIGO classification, hypertension is defined is defined according to the French society of hypertension and the WHO In group 1.

Results:
the average age is 57.10 +/- 3.55 years vs. 51.28 +/- 9.36 years in group 2. In CKD the hypertension is older (6.34 +/- 6, 18 years vs. 4.71 +/- 4.37 years). Compared to group 2, the ABPM evaluation of hypertension associated with CKD highlights the unbalanced, severe nature with loss of physiological dipping. In multivariate analysis, CKD and male sex are the predictors of no dipping and nocturnal hypertension in group 1

Conclusions:
Several studies highlight the peculiarities of hypertension in CKD. 6 to 50% of patients with CKD are non-dippers and 10 to 35% have nocturnal hypertension. These changes in BP are accompanied by cardiac and renal events in CKD. This underscores the value of continuous assessment of BP in patients with CKD.
BLOOD PRESSURE FROM THE OPTICAL AKTIIA BRACELET: A ONE MONTH VALIDATION STUDY USING AN ADAPTED ISO81060-2 PROTOCOL
Authors: Vybornova Anna , Wurzner-Ghajarzadeh Arlene , Polychronopoulou Erietta , Fallet Sybille , Sola Josep , Wuerzner Gregoire 
Published: April 2021

Objective:
Cuffless Blood Pressure (BP) monitoring is an emerging new technology with the potential to improve patients’ experience while providing physicians with a more comprehensive set out of office blood pressure measurements. The Aktiia Bracelet is a non-invasive BP monitor intended to measure optical photo-plethysmographic signals on the wrist and to calculate Systolic (SBP) and Diastolic (DBP) values using a pulse wave analysis technique. The Aktiia Bracelet requires an initialization procedure to be performed once per month. The objective of this study (NCT04027777) was to validate the accuracy and precision of the Aktiia Bracelet in the sitting position and over a period of one month.

Design and method:
A representative cohort of male and female, hypotensive, normotensive and hypertensive participants, aged 21 to 65 years, presenting different skin pigmentations (Fitzpatrick scale from 1 to 5) and different hair follicle densities were included. Four visits were scheduled for each participant. After initialization, the optical signals measured from the Aktiia Bracelet were used to calculate SBP and DBP values and were compared to auscultatory measurements obtained simultaneously by two double-blinded trained observers. The clinical investigation (including data analysis) was conducted by adapting the methods of ISO81060-2 to the requirements of a multi-visit validation of a cuffless device.

Results:
Data from a total of 91 participants in sitting position were included in the current analysis. For SBP, a mean difference (± SD) of 0.46 ± 7.74 mmHg between reference and Aktiia Bracelet values was found (criterion 1), with measured standard deviation of the averaged differences per subject of 3.9 mmHg (criterion 2). For DBP, a mean difference (± SD) of 0.39 ± 6.86 mmHg between reference and Aktiia Bracelet values was found, with measured standard deviation of the averaged differences per subject of 3.6 mmHg. Bland-Altman plots for SBP and DBP are shown in the following figure.

Conclusions:
The Aktiia Bracelet fulfilled the requirements of criterion 1 and 2 of the adapted ISO81060-2 protocol. The use of the Aktiia Bracelet could facilitate widespread use of accurate, longitudinal and easy out-of-office blood pressure measurements.
BLOOD PRESSURE MEASUREMENT METHODS AND KNOWLEDGE, PERCEPTION, PRACTICE OF NURSES: ARE WE THERE YET?
Authors: Todkar Shweta , Padwal Raj , Cloutier Lyne 
Published: April 2021

Objective:
Accurate Blood pressure measurement (BPM) is a fundamental aspect of hypertension management. Guidelines regarding BPM methods, namely home (HBPM), ambulatory (ABPM), office (OBPM) and automated (AOBP) are published by Hypertension Canada. Nurses commonly perform BPM, but little is known regarding their knowledge, perception and practice when considering all BPM methods. A recent scoping review concluded that insufficient data was available for all professionals, but specifically nurses. This descriptive study assessed knowledge, perception and practice of nurses regarding all BPM methods.

Design and method:
All nurses licensed to practice in primary care settings across Québec were targeted for this survey. A personalized email invitation, and 2 reminders, including a link to a secured platform was send between in December 2019. Data was collected using a validated and pretested questionnaire consisting of 48 questions for knowledge, perception and practice for all BPM methods in English and French.

Results:
A total of 447 nurses participated, with a response rate of 11%. The median age was 40.5 ± 11,5 years old and 92% were women. For knowledge and perception, the mean percentage score obtained are presented in Table 1. For practice, the most frequently recommended method was HBPM (47%), followed by ABPM (18%). One third (35%) nurses reported education for HBPM was frequently provided to their patients, while for ABPM it was only 18%. While AOBP is the preferred method in Canada, more than half (52%) never use it and only 57% use oscillometric device for OBPM, meaning that there are still a large number of measurements being performed manually by auscultation.

Conclusions:
Although nurses had positive perceptions about the use of out-of-office measurements there is still much room for improvement for knowledge and practice. Our results show that a gap remains between what is recommended, what is known, and what is actually done in the field. Further strategies should involve optimal use of educational resources such as BPM algorithm posters and booklets, optimizing patient centered care using team-based approach, incorporating HBPM and encouraging participation in certification programme offered by hypertension societies.
VALIDATION OF THE INBODY BPBIO750 OSCILLOMETRIC BLOOD PRESSURE MONITOR FOR PUBLIC SPACES (KIOSK) ACCORDING TO THE AAMI/ESH/ISO UNIVERSAL STANDARD
Authors: Ntineri Angeliki , Prapa Sofia , Bountzona Ioanna , Menti Ariadni , Stergiou George 
Published: April 2021

Objective:
To evaluate the accuracy of the upper-arm cuff oscillometric blood pressure (BP) monitor InBody BPBIO750 developed for self-measurement by adults in public spaces (kiosk) in general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018).

Design and method:
Subjects were recruited to fulfil the age, gender, BP and cuff distribution criteria of the AAMI/ESH/ISO Universal Standard in general population using the same arm sequential BP measurement method. The device has a fixed hole to insert the user's arm with a single implanted upper-arm cuff.

Results:
A total of 102 subjects were recruited and 85 were analyzed (mean age 56.7 ± 15.4 [SD] years, 40 men, arm circumference 32.3 ± 5.3 cm, range 22–42 cm). For validation Criterion 1, the mean ± SD of the differences between the test device and reference BP readings (N = 255) was 2.2 ± 6.1/-2.2 ± 5.2 mmHg (systolic/diastolic). For Criterion 2, the SD of the averaged BP differences between the test device and reference BP per individual (N = 85) was 5.00/4.63 mmHg (systolic/diastolic).

Conclusions:
The InBody BPBIO750 oscillometric device for BP measurement in public spaces fulfilled all the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) in general population and can be recommended for clinical use in adults.
PREVALENCE OF ARTERIAL HYPERTENSION IN THE UNORGANIZED POPULATION in ONE OF THE REGIONS OF KAZAKHSTAN
Authors: Chernokurova Yelena , Assembeko Batyrbek , Davletov Kairat , Amirov Baurzhan 
Published: April 2021

Objective:
The objectives of the study were to assess:

Design and method:
A cross-sectional study was conducted to assess the prevalence and risk factors of CVDs using the WHO STEPS questionnaire survey, physical measurements and biochemical measurements. Sample size was 1,500 people aged 18–69 years. Samples composition: 900 urban and 600 rural population according to the overall urban/rural residents ratio specific for the region.

Results:
Respondents were asked whether they have ever had blood pressure measurement and whether they had been diagnosed with high blood pressure. Among all age groups, 4.1% reported that their blood pressure had never been measured; 59.8% had undergone blood pressure measurement but had not been diagnosed with hypertension; 6.9 % had been diagnosed with high blood pressure more than a year before; and 31.3% had been diagnosed with hypertension within the 12 months prior to the interview. Some statistically significant differences emerged in terms of raised blood pressure history between the sexes. A total of 6.0% of men had never had their blood pressure measured, compared to3.5% of women. The percentage of women diagnosed with high blood pressure during the previous 12 months was higher (31.9%) than that of men (29.2%) (Table 1).
Compliance with high blood pressure treatment was found to be very low. Among all respondents aged 18–69 years diagnosed with high blood pressure, less than half were taking medication prescribed by a doctor or a health worker. The age group difference was statistically significant, with an increase in the proportion of those taking medication from 25.6% among the age group 18–34 years to 78.0% in the age group 55–69 years (Table 2).

Conclusions:
Coverage with blood pressure measurement was quite high among the respondents (over 95%, at almost twice higher proportion of males who never had measured their blood pressure). Almost third of respondents had been diagnosed with hypertension while compliance with proper treatment was insufficient.
THE SAFETY OF ANTIHYPERTENSIVE AGENTS ON PERIOPERATION OF CARDIAC SURGERY: A SYSTEMATIC REVIEW BASED ON META-ANALYSIS
Authors: Li Caie , Ma Liping , Wang Qiongying , Zhao Xu , Ma Ruixin , Li Ningyin , Yu Jing 
Published: April 2021

Objective:
To assess the safety of anti-hypertensive agents including calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists (ACEIs/ARBs), and beta blockers during perioperation of cardiac surgery.

Design and method:
We included randomized controlled trials investigating perioperative application of CCBs, ACEIs/ARBs or beta blockers in cardiac surgery. We extracted data for in-hospital mortality and serious side effects, among which atrial fibrillation (AF), stroke and acute renal failure (ARF) were assessed independently.

Results:
Twenty-three trials with 5378 patients were included. There were no significant differences between CCBs and placebo, nitroglycerin, or nitroprusside in terms of side effects, AF and ARF. Incidences of side effects (RR [95% CI] 0.55 [0.38, 0.80], I2=0, p < 0.01) and ARF (RR [95% CI] 0.16 [0.05, 0.53], I2=0, p < 0.01) were significantly reduced in ACEIs/ARBs group, compared with placebo, while differences in the incidences of AF and stoke were not found. No differences were found in the incidences of in-hospital death, side effects, ARF and stroke between beta blockers and placebo. However, use of beta blockers significantly reduced the incidence of AF (RR [95% CI] 0.51 [0.39, 0.67], I2=48%, p < 0.01).

Conclusions:
Perioperative use of CCBs, ACEIs/ARBs or beta blockers does not increase incidences of side effects in patients undergoing cardiac surgery and beta blockers are more appropriate in patients with high risk of postoperative atrial tachycardia. Large randomized trials are needed to confirm these findings.
DUAL INHIBITION OF ANGIOTENSIN II RECEPTOR- NEPRILYSIN COULD POSTPONE THE OXIDATIVE STRESS AND FIBROSIS IN THE GENITALTRACT OF FEMALE SPONTANEOUS HYPERTENSIVE RATS
Authors: Yu Jing 
Published: April 2021

Objective:
Hypertension-mediated organ damage(HMOD) usually refers to the heart, brain, kidney and peripheral blood vessels. Our previous study proved that female hypertensive patients are more likely to develop sexual dysfunction than women with normal blood pressure, female genital tract can also be described as one of the HMOD. In this study, we investigated the effects of AT1 receptor and neprilysin double blocker (Sacubitril / valsartan) on oxidative stress and fibrosis in the genital tract of female spontaneously hypertensive rats (SHR) rats.

Design and method:
16-week-old SPF-grade SHR rats were randomly divided into sacubitril / valsartan group, valsartan group, diuretic group (chlorothiazone),SHR group, and WKY group with 10 rats in each group. The systolic blood pressure(SBP), diastolic blood pressure(DBP) and mean arterial blood pressure(MBP) were obtained by measuring rat tail artery pressure. After 12 weeks, all the rats were operated, and their vaginal tissues were taken. The oxidative stress index (eNOS, nNOS protein expression) was measured by Western blotting, and the degree of vaginal fibrosis was observed by HE staining and Masson staining.

Results:
Sacubitril/valsartan, valsartan and chlorothiazone could all significantly reduce blood pressure, including SBP, DBP and MBP in SHR rats, and compared with valsartan and chlorothiazone groups, the decrease of SBP insacubitril / valsartan group was more significant.(p < 0.01). Compared with WKY group, the relative expression of eNOS, nNOS protein in vaginal tissue of SHR group was significantly lower than that of the control group, and there was significant difference between two groups (P < 0.01). In SHR, the relative expression of eNOS, nNOS protein in sacubitril / valsartan group and valsartan group was significantly up-regulated (P < 0.01). In SHR group, the thickness of vaginal epithelium was significantly increased, the collagen fibers increased significantly, and arranged disorder. The small artery wall in vaginal was thickened and stenoses.

Conclusions:
The gentital tract fibrosis in female SHR rats are related to oxidative stress. Sacubitril / valsartan is able to inhibit oxidative stress and inflammation, to reduce the fibrosis, and thus ameliorate the gentital tract remodeling in female SHR rats.
EFFECT OF MENOPAUSE ON BLOOD PRESSURE VARIABILITY AND CAROTID INTIMA-MEDIA THICKNESS IN WOMEN
Authors: Ye Runyu , Zhang Xin , Chen Xiaoping 
Published: April 2021

Objective:
To investigate the characteristics of blood pressure variability and carotid intima-media thickness in middle-aged hypertensive women during premenopausal, early perimenopausal, late perimenopausal and postmenopausal. And the effect of menopause status on them.

Design and method:
A total of 340 middle-aged hypertensive women were enrolled in this cross-sectional study. Each subject underwent anthropometric measurements, serum biochemistry evaluation, 24-h ambulatory blood pressure monitoring, and carotid ultrasound. According to their menstrual status, they were divided into four groups: group 1 (premenopausal), group 2 (early perimenopausal), group 3 (late perimenopausal) and group 4 (post menopausal).

Results:
There was no difference in mean blood pressure between the 4 groups, but a statistical difference in systolic blood pressure variability (standard deviation, coefficient of variation). On multiple linear regression analysis, SDs (all-day SBP, daytime SBP, nighttime SBP), CVs (all-day SBP, daytime SBP, nighttime SBP) were influenced by late peri-menopausal and postmenopausal status. And IMT was influenced by postmenopausal status. On logistic regression analysis, the risk of IMT thickening in postmenopausal women was 3.217 times higher than premenopausal (OR = 3.217 (1.325–7.811)), and the risk of plaque is 2.793 times higher than premenopausal (OR = 2.793 (1.443–5.404)).

Conclusions:
Late perimenopausal and menopausal status can increase blood pressure variability independently of age and BMI. Menopause status can significantly increase the risk of carotid intima-media thickening and carotid plaque.
THE EFFECT OF FREQUENT CONSUMPTION OF ENERGY DRINKS ON BLOOD PRESSURE, HEART RATE AND BLOOD GLUCOSE IN HEALTHY ADULTS WORKING OUT IN THE GYMNASIUM
Authors: Verma Abhinav , Vemra Narsingh , Siddiqui Mohd Ehsan 
Published: April 2021

Objective:
To assess the effect of frequent consumption of energy drinks on blood pressure, heart rate and blood glucose in healthy adults working out in the gymnasium.

Design and method:
200 healthy young adults, were divided into two groups: the first consumed at least three energy drinks at one-hour intervals, and the second drank the same amount of water. Systolic blood pressure (SBP), diastolic blood pressure(DBP),heart rate (HR) and blood glucose (BG) were measured before consumption of energy drink (250 ml per can)/ water (250 ml) and before working out. After working out for 45 minutes (treadmill, cycling and elliptical cross trainer) 1 hr of rest was given to both groups. SBP, DBP, HR and blood glucose were then measured. All participants could report any health problems before and after consuming each portion of energy drink. All parameters were measured thrice weekly for 3 months.

Results:
Having consumed three portions of ED (150 to 180 mg of caffeine), the participants presented a significant increase in DBP (p = 0.033), by over 10.32%, no significant change in SBP (p = 0.715). HR increased in adults drinking 3 energy drinks (p = 0.040). Consumption of EDs caused a significant increase (p < 0.001) in BG, by 23.5 %, on average. Some participants reported of palpitations and disturbed sleep which increased after 2 and 3 energy drinks.

Conclusions:
Increased diastolic blood pressure, blood glucose, no significant change in systolic blood pressure occurred in healthy young people as compared to their controls drinking water.
EFFECT OF SHIFT-WORK ON 7-DAY/24-H AMBULATORY BLOOD PRESSURE MONITORING
Authors: Siegelova Jarmila , Havelkova Alena , Pohanka Michal , Dusek Jiri , Dunklerova Leona , Dobsak Petr , Cornelissen Germaine 
Published: April 2021

Objective:
Poor health outcomes associated with shift work include increased risks of diabetes mellitus, dyslipidemia, hypertension, heart disease, peptic ulcer disease, depression and cancer.
The aim of the study was to compare the 7-day/24-h blood pressure ambulatory monitoring in healthy subjects and nurses working in day and night work shifts.

Design and method:
We examined 297 healthy subjects and 6 women (age 33 ± 2 years, body weight 70 ± 21 kg, mean height 165 ± 5 cm) and 4 men (age 28 ± 7 years, body weight 93 ± 11 kg, mean height 185 ± 5 cm), in days with day work, days with night work and free days, using Medical Instruments TM2431 (A and D, Japan).

Results:
The mean (±SD) of sleep hours in the week in 10 nurses during 7-day/24-h blood pressure monitoring was 37.75 ± 2.75 h per week. The mean of 7-day/24-h ambulatory blood pressure monitoring was SBP 126 ± 7.6 mmHg, of DBP 76 ± 5 mmHg, of HR 74 ± 5 bpm. Contrary to healthy subjects, in all shift workers we have found the disturbences in circadian rhythm according the day and night shifts. The seven day/24-hour systolic blood pressure profiles vary from 110 to 140 mmHg and we can not use reference values for 24-h ambulatory blood pressure monitoring, while there is impairment in circadian rhythm because of irregular night work. The similar condition is valid for diastolic blood pressure. Longitudinal monitoring could be implemented more generally to assess inter-individual responds to shift work.

Conclusions:
Seven day/24-h ambulatory blood pressure monitoring in night shift workers showed impairment of circadian rhythm and BP vary according to the work depending on different working shifts, and decrease of sleep hours. Further work is also needed to determine whether there may be shift work schedules that are less detrimental than others.
NEW CONCEPT OF TRIGGER-SPECIFIC BLOOD PRESSURE SENSITIVITY “THERMOSENSITIVITY” MEASURED BY ICT-BASED MULTISENSOR ABPM IN PATIENTS WITH HEART FAILURE
Authors: Narita Keisuke , Hoshide Satoshi , Kario Kazuomi 
Published: April 2021

Objective:
A sudden elevation of blood pressure (BP) by cold temperatures in winter is widely recognized as one of causes in exacerbation of heart failure. A reactivity of BP against changes in temperature in ambulatory setting remains unclear in patients with heart failure. We assessed the BP reactivity against changes of temperature using a newly developed device ICT-based Multisensor Ambulatory BP Monitoring (IMS-ABPM) in patients with heart failure.

Design and method:
The IMS-ABPM has accelerometer, thermometer and atmospheric barometer, which enable to measure physical activity, temperature and atmospheric pressure with measuring ambulatory BP. In this study, we evaluated trigger-specific BP sensitivity according to the ambulatory BP reactivity based on the slope of BP change against the triggers using the IMS-ABPM, which was “thermosensitivity” defined as the slope of BP change against temperature in the BP measurement. This study was a cross-sectional study to assess relationship between “thermosensitivity” and cardiac function by using IMS-ABPM in patients who had been admitted to a medical facility due to heart failure.

Results:
Among 103 patients with heart failure (mean ± SD age, 76.4 ± 14.4 years; 47.6% men), 55.6% of patients was heart failure with preserved ejection fraction (HFpEF). Although mean 24-hour systolic BP level and ambulatory BP variability evaluated coefficient of variation, average real variability had not significant difference between patients with HFpEF and heart failure with reduced ejection fraction (HFrEF), the thermosensitivity was significantly lower (hyperthermosensitive) in patients with HFpEF compared to HFrEF (HFpEF, –1.59 ± 3.22 vs. HFrEF, 0.08 ± 4.14, p = 0.038). After adjusted age and sex, the thermosensitivity was significantly associated with HFpEF. Moreover, the thermosensitivity tended to be correlated with ejection fraction in echocardiography (r = –0.21, p = 0.052 in Spearman's correlation).

Conclusions:
Based on the results of this study, patients with HFpEF showed lower thermosensitivity (hyperthermosensitive), which suggested BP strongly elevated with cold temperature, compared to patients with HFrEF. The new concept of trigger-specific BP sensitivity “thermosensitivity” might be associated with the exacerbation of heart failure in HFpEF.