bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the outcome between immunotherapy alone or in combination with chemotherapy in EGFR-mutant non-small cell lung cancer
Authors: Shen Chia-I , Chao Heng-Sheng , Shiao Tsu-Hui , Chiang Chi-Lu , Huang Hsu-Ching , Luo Yung-Hung , Chiu Chao-Hua , Chen Yuh-Min 
Published: August 2021

AbstractWhether ICIs combined with chemotherapy can improve outcomes in EGFR-mutant non-small cell lung cancer (NSCLC) remains uncertain. Patients with EGFR-mutant NSCLC and who progressed on first-line EGFR-TKIs treatment were retrospectively collected. We reviewed the outcome of these patients treated with ICIs or ICIs combined chemotherapy (ICI + C). Total 30 patients were included. The ORR were 9.1% and 25.0% for the ICI and ICI + C groups. The ICI + C group showed the trend of longer progression-free survival and overall survival periods. Patients without the T790M mutation had a significantly longer PFS than did those without this mutation (4.23 [95% CI: 2.75–5.72] vs. 1.70 [95% CI: 0.00–3.51] months, HR:4.45, p = 0.019). ICIs combined with chemotherapy tended to be more effective than ICIs alone in pretreated EGFR-mutant NSCLC. The T790M mutation may be a potential biomarker.
UHPLC–electrospray ionization–mass spectrometric analysis of brain cell-specific glucogenic and neurotransmitter amino acid content
Authors: Bheemanapally Khaggeswar , Napit Prabhat R. , Ibrahim Mostafa M. H. , Briski Karen P. 
Published: August 2021

AbstractAstrocyte glycogen, the primary energy reserve in brain, undergoes continuous remodeling by glucose passage through the glycogen shunt prior to conversion to the oxidizable energy fuel l-lactate. Glucogenic amino acids (GAAs) are a potential non-glucose energy source during neuro-metabolic instability. Current research investigated whether diminished glycogen metabolism affects GAA homeostasis in astrocyte and/or nerve cell compartments. The glycogen phosphorylase (GP) inhibitor 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) was injected into the ventromedial hypothalamic nucleus (VMN), a key metabolic-sensing structure, before vehicle or l-lactate infusion. Pure VMN astrocyte and metabolic-sensory neuron samples were obtained by combinatory immunocytochemistry/laser–catapult-microdissection for UHPLC–electrospray ionization–mass spectrometry (LC–ESI–MS) GAA analysis. DAB inhibition of VMN astrocyte aspartate and glutamine (Gln) levels was prevented or exacerbated, respectively, by lactate. VMN gluco-stimulatory nitric oxide (NO; neuronal nitric oxide synthase-immunoreactive (ir)-positive) and gluco-inhibitory γ-aminobutyric acid (GABA; glutamate decarboxylase65/67-ir-positive) neurons exhibited lactate-reversible asparate and glutamate augmentation by DAB, but dissimilar Gln responses to DAB. GP inhibition elevated NO and GABA nerve cell GABA content, but diminished astrocyte GABA; these responses were averted by lactate in neuron, but not astrocyte samples. Outcomes provide proof-of-principle of requisite LC–ESI–MS sensitivity for GAA measurement in specific brain cell populations. Results document divergent effects of decreased VMN glycogen breakdown on astrocyte versus neuron GAAs excepting Gln. Lactate-reversible DAB up-regulation of metabolic-sensory neuron GABA signaling may reflect compensatory nerve cell energy stabilization upon decline in astrocyte-derived metabolic fuel.
Synthetic approach of ternary magnesium niobate (Mg–Nb–O) compounds
Authors: Rahman Md. Wasikur 
Published: August 2021

AbstractMagnesium based niobium oxides (Mg–Nb–O) were prepared by solid-state reactions owing to understand the function of transition metal oxides as promoters/catalysts for practical application. Magnesium niobate (Mg3Nb6O11) was synthesized for the first time in nearly pure form reported in this context. MgNb2O6 and Mg4Nb2O9 were prepared in oxidizing conditions; on the contrary, Mg3Nb6O11 preferred reducing environment. Stoichiometric mixtures of the precursor materials MgO, Nb2O5 and/or metallic Nb were annealed for the syntheses which revealed the effect of temperature on phase formation, reaction kinetics and heat of reaction. The products were examined by ex-situ, in-situ X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Crystallographic parameters of various binary and ternary compounds (Mg/Nb/O) formed in different calcination conditions, were extracted by Rietveld method. In-situ experiment results in single step reaction for the MgNb2O6 synthesis and the heat of formation of the solid-state reaction obtained to be minimum (93 kJ/mol). In contrast, the formation of Mg4Nb2O9 and Mg3Nb6O11 compounds towards pure phases rather complicated due to multistep reactions and corresponding heat of formation were estimated to be 140 and 190 kJ/mol. Experimental results have been discussed based on kinetic and thermodynamic constrains.
Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [18F]JNJ-64413739 PET and MRA-driven image derived input function
Authors: Mertens Nathalie , Schmidt Mark E. , Hijzen Anja , Van Weehaeghe Donatienne , Ravenstijn Paulien , Depre Marleen , de Hoon Jan , Van Laere Koen , Koole Michel 
Published: August 2021

Abstract[18F]JNJ-64413739 has been evaluated as PET-ligand for in vivo quantification of purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a metabolite-corrected arterial plasma input function. In the context of a P2X7R PET dose occupancy study, we evaluated a minimally invasive approach by limiting arterial sampling to baseline conditions. Meanwhile, post dose distribution volumes (VT) under blocking conditions were estimated by combining baseline blood to plasma ratios and metabolite fractions with an MR angiography driven image derived input function (IDIF). Regional postdose VT,IDIF values were compared with corresponding VT,AIF estimates using a arterial input function (AIF), in terms of absolute values, test–retest reliability and receptor occupancy. Compared to an invasive AIF approach, postdose VT,IDIF values and corresponding receptor occupancies showed only limited bias (Bland–Altman analysis: 0.06 ± 0.27 and 3.1% ± 6.4%) while demonstrating a high correlation (Spearman ρ = 0.78 and ρ = 0.98 respectively). In terms of test–retest reliability, regional intraclass correlation coefficients were 0.98 ± 0.02 for VT,IDIF compared to 0.97 ± 0.01 for VT,AIF. These results confirmed that a postdose IDIF, guided by MR angiography and using baseline blood and metabolite data, can be considered for accurate [18F]JNJ-64413739 PET quantification in a repeated PET study design, thus avoiding multiple invasive arterial sampling and increasing dosing flexibility.
Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage
Authors: Anetsberger Aida , Jungwirth Bettina , Blobner Manfred , Ringel Florian , Bernlochner Isabell , Heim Markus , Bogdanski Ralph , Wostrack Maria , Schneider Gerhard , Meyer Bernhard , Graeßner Martin , Baumgart Lea , Gempt Jens 
Published: August 2021

AbstractTroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1–3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.
Comparison of machine and deep learning for the classification of cervical cancer based on cervicography images
Authors: Park Ye Rang , Kim Young Jae , Ju Woong , Nam Kyehyun , Kim Soonyung , Kim Kwang Gi 
Published: August 2021

AbstractCervical cancer is the second most common cancer in women worldwide with a mortality rate of 60%. Cervical cancer begins with no overt signs and has a long latent period, making early detection through regular checkups vitally immportant. In this study, we compare the performance of two different models, machine learning and deep learning, for the purpose of identifying signs of cervical cancer using cervicography images. Using the deep learning model ResNet-50 and the machine learning models XGB, SVM, and RF, we classified 4119 Cervicography images as positive or negative for cervical cancer using square images in which the vaginal wall regions were removed. The machine learning models extracted 10 major features from a total of 300 features. All tests were validated by fivefold cross-validation and receiver operating characteristics (ROC) analysis yielded the following AUCs: ResNet-50 0.97(CI 95% 0.949–0.976), XGB 0.82(CI 95% 0.797–0.851), SVM 0.84(CI 95% 0.801–0.854), RF 0.79(CI 95% 0.804–0.856). The ResNet-50 model showed a 0.15 point improvement (p < 0.05) over the average (0.82) of the three machine learning methods. Our data suggest that the ResNet-50 deep learning algorithm could offer greater performance than current machine learning models for the purpose of identifying cervical cancer using cervicography images.
Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
Authors: Prieto-Peña Diana , Remuzgo-Martínez Sara , Genre Fernanda , Pulito-Cueto Verónica , Atienza-Mateo Belén , Llorca Javier , Sevilla-Pérez Belén , Ortego-Centeno Norberto , Marquez Ana , Lera-Gómez Leticia , Leonardo María Teresa , Peñalba Ana , Narváez Javier , Martín-Penagos Luis , Rodrigo Emilio , Miranda-Filloy José A. , Caminal-Montero Luis , Collado Paz , Sánchez Pérez Javier , de Argila Diego , Rubio Esteban , León Luque Manuel , Blanco-Madrigal Juan María , Galíndez-Agirregoikoa Eva , Gualillo Oreste , Martín Javier , Castañeda Santos , Blanco Ricardo , González-Gay Miguel A. , López-Mejías Raquel 
Published: August 2021

AbstractCytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.
Population-wide impacts of aspirin, statins, and metformin use on prostate cancer incidence and mortality
Authors: Koo Hye Yeon , Jeong Su-Min , Cho Mi Hee , Chun Sohyun , Shin Dong Wook , Park Jinsung 
Published: August 2021

AbstractWe evaluated the association between aspirin, statins, and metformin use and prostate cancer (PC) incidence and mortality using a large population-based dataset. 388,760 men who participated in national health screening program in Korea during 2002–2003 were observed from 2004 to 2013. Hazard ratios of aspirin, statins, and metformin use for PC incidence and PC mortality were calculated with adjustment for simultaneous drug use. Cumulative use of each drug was inserted as time-dependent variable with 2-year time windows. Aspirin use ≥ 1.5 year (per 2-year) was associated with borderline decrease in PC mortality when compared to non-users (adjusted hazard ratio [aHR] 0.71, 95% confidence interval [CI] 0.50–1.02). Statins use was not associated with either PC incidence or PC mortality. Metformin ever-use was associated with decreased PC incidence compared with non-diabetics (aHR 0.86, 95% CI 0.77–0.96). Diabetics who were not using metformin or using low cumulative doses had higher PC mortality than non-diabetics (aHR 2.01, 95% CI 1.44–2.81, and aHR 1.70, 95% CI 1.07–2.69, respectively). However, subjects with higher cumulative doses of metformin did not show increased PC mortality. In conclusion, metformin use was associated with lower PC incidence. Use of aspirin and that of metformin among diabetic patients were associated with lower PC mortality.
Identification and characterization of Crassostrea angulata arginine kinase, a novel allergen that causes cross-reactivity among shellfish
Authors: Huan Fei , Han Tian-Jiao , Liu Meng , Li Meng-Si , Yang Yang , Liu Qing-Mei , Lai Dong , Cao Min-Jie , Liu Guang-Ming 
Published: August 2021

AK was identified as a novel allergen in C. angulata, and rAK maintaining IgG/IgE-binding activity and structural integrity was obtained. Notably, the cross-reactivity of shellfish AK may be related to conserved epitopes.
Intestinal congestion and reperfusion injury: damage caused to the intestinal tract and distal organs
Authors: Chen Yajing , Pu Weigao , Maswikiti Ewetse Paul , Tao Pengxian , Li Xuemei , Wang Dengfeng , Gu Baohong , Yu Yang , Gao Lei , Zhao Chengji , Chen Hao 
Published: August 2021

Abstract
In clinical practice, intestinal autologous diseases, ailments and organ transplants can cause severe congestive damage to the intestinal tract. However, after the etiological factor is gotten rid of and blood flow is free without any hinderance, further damage to the intestinal wall often occurs, causing other related organ dysfunctions. This ultimately results in intestinal congestion reperfusion injury (ICRI). When the structure and function of the intestine are destroyed, bacteria, metabolites and endotoxins in the intestinal tract perfuse and enter the portal vein through the already compromised intestinal mucosa, to the other organs via the liver. Nevertheless, this gives rise to further aggravation of the injury, and reperfusion injury syndrome occurs. ICRI is a very common complication encountered by clinicians, and its harm is more severe and serious as compared with that caused by ischemia–reperfusion. Quite a few number of studies on ICRI have been reported to date. The exact mechanism of the injury is still idiopathic, and effective treatment strategies are still limited. Based on recent studies, this article is aimed at reviewing the destruction, damage mechanisms resulting from ICRI to the intestinal anatomical sites and distant organs. It is geared towards providing new ideas for the prevention and therapeutic approaches of ICRI.
Optimal Lp filtering for discrete‐time non‐Gaussian dynamic systems
Authors: Javanfar Elham , Rahmani Mehdi 
Published: August 2021

AbstractThis paper investigates the filtering problem for linear dynamic systems. The main objective is to discuss the optimal filter for non‐Gaussian systems. The filter structure is obtained by extension of the maximum a posteriori estimation problem for general norm exponential probability density functions. The obtained filter has a linear structure, and two different algorithms are proposed for and . In the following, the choice of has been discussed based on the asymptotic distribution and the central limit theorem as well as the kurtosis of error probability density function. Both of them confirm that the filter is optimal for Gaussian systems, and the filter, for , has the best performance for the systems with leptokurtic error distributions, and for , it is the best for the systems with platykurtic error distributions. In this regard, it is shown that the and filters have the best MSE performance for the systems with Laplacian and uniform error probability distribution functions, respectively. Simulation results verify the superior performance of the proposed filtering approach for linear time‐invariant and time‐varying systems.
Origine des inclusions dans les aciers peu alliés
Authors: Gatellier C. , Gaye H. , Lehmann J. 
Published: August 2021

Dans cette synthèse bibliographique est donnée une description de la nature des principales inclusions susceptibles de se retrouver dans un échantillon d'acier au carbone brut de coulée.
Uévolution potentielle de la morphologie et de la composition de certaines inclusions à haute température et leur comportement rhéologique au cours du laminage à chaud de l'acier sont ensuite discutés.
Drawing places, recreating spaces: visual voices from at-risk children
Authors: Pinto Giuliana , Tosi Francesco , Incognito Oriana 
Published: August 2021

AbstractDrawing is a highly participatory mode of communication, particularly suited to allowing children to express their knowledge and ideas about various aspects of reality. It is necessary to ascertain whether children are able to master drawing sufficiently to place it at the service of their representational intentions, and whether they possess the pictorial flexibility needed to articulate and differentiate their graphic representations. The presence and development of this important cognitive–symbolic ability are investigated. This exploratory study aimed to investigate, in children living in socioeconomic and cultural disadvantaged conditions, (1) the emergence and development of the pictorial flexibility needed to effectively represent and differentiate the building in which they live from the building in which they wish they lived; and (2) the patterns in the number and quality of pictorial differentiation strategies adopted for representational purposes. Two-hundred 8-to-12-year-old Brazilian children living in a favela were asked to produce two specific thematic drawings, representing their real house vs. their desired house. The children’s pictorial representations were coded according to their communicative efficacy (allowing the viewer to distinguish, in each pair of drawings, between the real house and the one desired by the drawer) and according to the number and type of pictorial strategies used to diversify the two types of buildings. The children were had sufficient representational flexibility to effectively perform a pictorial differentiation task, and express their point of view on the environment in which they live, and imagine alternative scenarios, adopting a variety of painting strategies. Drawing, prompted with a contrastive task, has proven to be effective in allowing even disadvantaged children to differentiate their real and desired urban environments. Children’s pictorial flexibility manifests itself through a wide range of strategies, varying in number and quality according to the age of the artists. As such, its use can be encouraged by educational interventions aimed at broadening the expressive potential of children, and as a tool for fostering resilience.
Impurity charge compensation in graphene by a polarized ferroelectric polymer and its effect on charge transport near the Dirac point
Authors: Figueroa Kelotchi S. , Zimbovskaya Natalya A. , Pinto Nicholas J. , Wen Chengyu , Johnson A. T. Charlie 
Published: August 2021

Charge transport near the Dirac point (DP) was investigated in graphene using ferroelectric (FE) gating in the temperature range of 300 &lt; T &lt; 350 K. We observed that the conductivity (σ) near the DP had a positive temperature gradient that switched to a negative temperature gradient with increasing temperature. The switch to a negative temperature gradient shifted to higher temperatures and gradually weakened upon moving away from the DP. Impurity charge compensation via polarization of the FE together with a temperature-dependent graphene–impurity charge separation was proposed as being responsible for the non-monotonicity in σ(T). A self-consistent theory for graphene transport with impurity charge scattering and phonon scattering was used to analyze the results. Non-monotonic charge transport was also observed in the temperature dependence of the residual conductivity (σr). Theoretical analysis of both σ and σr revealed a temperature independent contribution of ∼1.16e2h that is probably inherent to pristine graphene.
Steiner Decomposition Number of Complete ռ —Sun graph
Authors: Ebin Raja Merly E. , Mahiba M. 
Published: August 2021

Abstract
If each subgraph of the decomposition π of the graph G has the Steiner number same as G then π is said to be a Steiner decomposition of G. The maximum cardinality among the Steiner decomposition π of G is the Steiner decomposition number of G and is denoted by π

st
(G). In this paper, we present the Steiner decomposition number for Complete n-Sun graph.
Prime Cordial Labeling of Some Graphs
Authors: Gayathri K. , Sasikala A. , Sekar C. 
Published: August 2021

Abstract
A bijectionfrom the vertex set V of a graph G to {1,2,…|V|} is called a prime cordial labeling of G if each edge uv is assigned the label 1 if gcd (f (u), f (v)) = 1 and 0 if gcd (f (u), f (v)) > 1, where the number of edges labeled with 0 and the number of edges labeled with 1 differ at most by one. In this paper we prove that 8-polygonal snake containing n number of 8-polygon, Splitting graph of Cn for n ≥ 5 and Armed Crown C2k Pm for all k ≥ 3 and m ≥ 2 admit prime cordial labeling.
Symmetric Prime and Symmetric Semiprime Ideals in Symmetric Semirgroups
Authors: Punitha Tharani A. , Uma Maheswari V. 
Published: August 2021

Abstract
In this note we introduce the notion of Symmetric Prime and Symmetric Semiprime ideals in Symmetric Semiroups and we define completely symmetric prime and completely symmetric semiprime ideals also we derive some results based on the above concepts.
Ascending Bi-Pendant Domination Decomposition of Path and Cycle
Authors: Brishni V. , Maheswari V. , Bala Deepa Arasi K. 
Published: August 2021

Abstract
Let G = (V, E) be a simple connected graph. A pendant dominating set S of a graph G is a bi-pendant dominating set if V-S also contains pendant vertex. The least cardinality of the bi-pendant dominating set in G is called the bi-pendant domination number of G denoted by γ
b
p
e (G). If G
1, G
2, G
3, …, G

n
are connected edge disjoint sub graphs of G with E(G) = E(G
1) ∪ E(G
2) ∪ E(G
3) …∪ E(G

n
), then G
1, G
2, G
3, …, G

n
is said to be decomposition of G. In this paper, we define Ascending Bi-Pendant Domination Decomposition (ABPDD) and discuss the values of m in P

m
and C

m
which admits APBDD into n-parts.