bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic effects of ramipril and indapamide in hypertensive patients with non-alcoholic fatty liver disease
Authors: Statsenko M. E. , Streltsova A. M. 
Published: October 2021

Objective. To assess the effects of combined antihypertensive therapy with ramipril and indapamide on insulin resistance, carbohydrate, lipid and purine metabolism, as well as the structure and function of the liver in hypertensive patients with non-alcoholic fatty liver disease (NAFLD).Design and methods. In a pre-post study, we included 30 patients with hypertension (HTN) 1–2 degrees in combination with NAFLD (Fatty Liver Index (FLI) > 60) aged 45 to 65 years. Patients discontinued antihypertensive therapy 5–7 days before the initial examination. After that one of the fixed combinations of ramipril (2,5/5 mg/day) and indapamide (0,625/1,25 mg) were prescribed along with the lifestyle and weight reduction recommendations (the Mediterranean type of diet, a decrease in calorie intake by 500–1000 kcal from baseline, and physical aerobic exercise at least 150 minutes per week). All patients underwent clinical examination, measurement of office blood pressure (BP), ambulatory BP monitoring (ABPM), anthropometric parameters, assessment of the visceral obesity index (VAI), anthropometric parameters, VAI, the degree of adipose tissue dysfunction (ATD), the percentage of visceral and subcutaneous fat by the bioelectrical impedance method. We also assessed lipid, carbohydrate, purine metabolism and the structural and functional state of the liver before and after the treatment.Results. After 24-week therapy with a fixed combination of ramipril and indapamide (average dosage of 4,04 ± 1,24 and 1,01 ± 0,31 mg, respectively) HTN patients with NAFLD achieved target BP. There was a decrease in both office systolic BP (SBP) (p < 0,001) and office diastolic BP (DBP) (p = 0,007) in 100 % of patients, as well as in ABPM indices. We observed a decrease in waist and hip circumferences (p ≤ 0,001 and p ≤ 0,001, respectively), the proportion of subcutaneous (p = 0,0134) and visceral (p = 0,002) fat. The number of patients with normal ATD increased (p = 0,030), while the proportion of patients with dysfunction decreased (p = 0,039). There was also a significant increase in high-density lipoprotein cholesterol (p = 0,027) and a decrease in insulin resistance (p = 0,002) and metabolic index (p = 0,030). We also found an improvement in carbohydrate metabolism with no change in purine metabolism. There was a favorable effect on the liver structure and function, and the number of patients with high alaninaminotransferase > 40 U/L decreased (5 (16,7 %) vs 0, p = 0,026).Conclusions. Twenty-fourweek treatment with a fixed combination of ramipril and indapamide, together with recommendations for lifestyle changes and weight loss, led to a significant decrease in BP levels, the severity of insulin resistance, and visceral obesity. In addition, the treatment had a beneficial effect on the parameters of carbohydrate and lipid metabolism, as well as liver structure and function (decreased severity of steatosis and fibrosis).
EXPERIÊNCIA DE PROFESSORES-TUTORES NA MUDANÇA METODOLÓGICA DO CURSO DE ADMINISTRAÇÃO 100% EAD EM UMA IES PRIVADA
Authors: Kuabara Flávia Harumi Souza , Coelho Tavany Cibele , Bustamante Ana Carolina de Melo 
Published: October 2021

A pesquisa discorre sobre o desenvolvimento do ensino à distância e as possibilidades dialógicas no processo de ensino-aprendizagem por meio da tecnologia da informação, bem como a inserção de uma tecnologia estabelecendo uma nova dinâmica no processo de comunicação. Objetiva-se apresentar a mudança metodológica do curso de Administração 100% a distância de uma IES privada a partir da perspectiva dos professores-tutores. Para tanto, este trabalho caracteriza-se como um relato de experiência como método de pesquisa qualitativa. Segundo Domingues (2016), caracteriza-se como uma narrativa trazendo vivências educacionais contribuindo para conhecimentos pedagógicos. Os processos da mudança da metodologia do curso de Administração 100% EaD, foram acessados por meio de entrevistas aplicadas a professores-tutores que vivenciaram as duas metodologias, e professores-tutores que apenas conheceram a experiência dos encontros virtuais, além de dados secundários que demonstram a adesão dos estudantes às aulas virtuais. Após as mudanças realizadas, o encontro virtual é visto pelos professores-tutores como um recurso que trouxe aspectos positivos, pois é de fácil acesso e o aluno não precisa estar síncrono no momento de sua realização em função da possibilidade de assistir ao encontro gravado, além de fazer com que o professor-tutor inove com didáticas pedagógicas e tecnológicas. Porém, por outro lado, a transformação da videoconferência em videoaula pode indicar conflitos estruturais dos recursos afetando a fluidez da comunicação, até mesmo podendo ser a causa do desinteresse por parte do aluno.

Palavras-chave: EaD. TICs. Encontro Virtual. Papel do Professor-tutor.
Efecto de una dieta sin antibióticos, coccidiostatos y aminoácidos sintéticos en pollos sexados Cobb 500
Authors: Sánchez Quinche Angel Roberto , Muñoz Izquierdo Carla Dennisse , Jurado Correa Juan Marcelo , León Armijos Erika María , Pimbosa Ortiz Dioselina Esmeralda 
Published: October 2021

La presente investigación se desarrolló en el área experimental de la Granja Santa Inés perteneciente a la Facultad de Ciencias Agropecuarias de la Universidad Técnica de Machala-Ecuador, con la finalidad de evaluar el efecto de una dieta sin antibióticos, coccidiostatos y aminoácidos sintéticos, administrada a pollos Cobb 500 sexados sobre los parámetros productivos: Peso vivo, consumo de agua y alimento acumulado, conversión alimenticia, mortalidad, peso ante mortem, peso de la canal y porcentaje de rendimiento de la canal. Se empleó un DCA, en el cual se utilizó un único factor a manipular, el balanceado, separando los machos de las hembras, de una muestra de 100 aves, aplicando una réplica por sexo, dando como resultado 4 unidades experimentales (jaulas), con 25 unidades muestrales (pollos) por replica, las jaulas fueron distribuidas con un número 1 y 4 (hembras), 2 y 3 (machos), cuyos datos se procesaron semanalmente. Para el análisis estadístico, se empleó el programa Statgraphics Centurión XV.I.®, aplicando un ANOVA y para establecer las diferencias entre las medias se usó el procedimiento de comparación múltiple de Bonferroni con un nivel del 95,0% de confianza. Los resultados muestran que los machos a partir de la 2da semana presentan los mejores pesos, así como el mejor peso de la canal, mientras que en el porcentaje de rendimiento de la canal y consumo de agua de bebida destacan las hembras sobre todo en los últimos días del experimento. Demostrando un efecto marcado en algunas variables, al someter a los sexos a una dieta especial.
Investigation of shape stability of semi-finished samples in the form of a ring made of plastic ceramic material based on SiC, obtained by injection molding
Authors: Psiarnetska Tetiana , Tsysar Maksym , Lyeshchuk Oleksandr 
Published: October 2021

The concept of form stability is considered. A semifinished product in the form of a ring from a thermoplastic mass based on SiC powder has been made on the installation for injection molding developed at the Bakul Institute for Superhard Materials of the National Academy of Sciences of Ukraine in accordance with the established technological parameters optimized by the results of computer modeling. Schemes of loading and dividing the ring into samples in the form of prismatic segments are presented. A technique for the preparation of experimental samples is proposed. The study of the compressive strength of the samples from the injected semi-finished product has been carried out on the FP-5 mechanical test machine and a corresponding здще of its change has been constructed. The formation of a barrel shape during compression tests of samples, both along the radial and tangential directions, has been established. The values of the minimum and maximum loads at which the samples are destroyed have been determined. An increase in the compaction of the thermoplastic mass around the injection point has been experimentally proved. The scheme and the actual image of crack distribution as a result of destruction of samples have been presented. It is shown that the failure occurs in the area of the presence of the calculated parting lines, which have become stress concentrators.
Simultaneous Bilateral Latissimus Dorsi Tendon Ruptures
Authors: Ahmad Aamir N. , Hankins David A. , Wascher Daniel C. 
Published: October 2021

Case:
We report a case of a 55-year-old man who sustained bilateral, complete latissimus dorsi tendon ruptures during a water-skiing accident. Physical examination and magnetic resonance imaging confirmed the patient's diagnosis but also revealed a tear of the teres major on the left side. Staged primary repair was performed on each side, with a 6-week interval between procedures. At 1-year follow-up, the patient had an excellent clinical outcome.

Conclusion:
Staged surgical repair of bilateral latissimus dorsi tendon ruptures can be performed, leading to excellent clinical and functional outcomes for patients.
Treatment of an Extruded Middle Phalanx Epiphysis in a 6-Year-Old Boy
Authors: Lentz Jonathon , Klingbeil Laura , Hochwald Neal , Dagly Kamal 
Published: October 2021

Case:
A Salter-Harris II fracture of the small finger middle phalanx with complete extrusion of the epiphyseal fragment in a 6-year-old boy is described. Closed reduction was unsuccessful. Open reduction was performed, the epiphysis was reduced, and a single Kirschner wire was placed obliquely across the fracture and joint.

Conclusion:
This is an extremely rare injury. Open reduction and pinning was successful in preserving functional range of motion. Despite eventual growth arrest, there was no clinically significant angular deformity, and the joint was preserved. Surgical technique and early hand therapy allowed the patient to return to high-level activity without pain or functional limitation thus far at the 27-month follow-up.
Novel Utilization of Anterior Intrapelvic (Stoppa) Approach for Periacetabular Ganz Osteotomy
Authors: Klahs Kyle J. , Castagno Christopher , Tadlock Joshua , Garcia E’Stephan , Abdelgawad Amr , Thabet Ahmed M. 
Published: October 2021

Case:
The Ganz periacetabular osteotomy (PAO) is widely used to correct developmental hip dysplasia in the adolescent and young adult population. The aim of this case study was to examine the novel utility and safety of Stoppa approach for the Ganz PAO in a 15-year-old girl and 25-year-old man. The Stoppa approach is traditionally used for acetabular fractures, and its use for a Ganz PAO is relatively novel.

Conclusion:
The Stoppa approach allows surgeons to successfully perform the Ganz PAO while simultaneously providing direct visualization for all osteotomies and vital structures.
Lymphatic Injury with Lymph Fistula After Anterior Lumbar Fusion Managed with Vacuum-Assisted Closure
Authors: Hartnett Davis A. , Zhang Andrew S , Hogan William B. , Daniels Alan H. 
Published: October 2021

Case:
A 40-year-old man underwent an L5-S1 anterior lumbar interbody fusion (ALIF) and subsequently developed abdominal distention and persistent wound drainage. During wound reexploration, a substantial lymphocele and lymphatic fistula tracking from the ALIF site were visualized and evacuated. The deep space was coated with fibrin sealant. A deep drain and wound vacuum were placed within the retroperitoneal cavity, leading to progressive recovery.

Conclusion:
Intraoperative lymphatic injury during anterior spinal surgery can progress to the development of a lymphocele and lymphatic fistula, manageable with an exploratory laparotomy, fibrin sealant, and the use of a wound vacuum to promote fistula sealing.
Notes on the distribution, morphological variation, and mechanoreceptors of Tretanorhinus nigroluteus (Serpentes: Dipsadidae) in Colombia
Authors: García-Cobos Daniela , Vásquez-Restrepo Juan Daniel 
Published: October 2021

Aquatic species are among the least studied groups of snakes in Colombia. This is mainly due to their ecology, which makes some species difficult to survey, resulting mostly in fortuitous encounters. Within this group is the genus Tretanorhinus, for which there are records of two species in Colombia, T. mocquardi and T. taeniatus, along with a possible third one, T. nigroluteus. The presence of T. nigroluteus in Colombia has been problematic, since records are based on misidentifications and incomplete information. Here we extend the distribution of this species to the Pacific region of Colombia and discuss the uncertainty of the previous record. We also compare the morphological variation of the only Colombian specimen currently known with individuals of Central America, finding that this individual differs in having a black dorsal ground color without punctulations and a darkened belly. Nonetheless, we consider this combination of scales and color as previously unknown intraspecific variation. Finally, we report for the first time the presence of dome-shaped cephalic mechanoreceptor sensilla for the genus, quantify its density and size for six cephalic scales, and discuss the possible taxonomic value of these structures.
Aspectos de la reproducción de Plagioscion magdalenae (Pisces: Sciaenidae) en el embalse El Guájaro, bajo Magdalena, Colombia
Authors: Garcia-Alzate Carlos , Rojas-Luna René A. 
Published: October 2021

Plagioscion magdalenae es el recurso íctico más importante del embalse El Guájaro, en el norte de Colombia, y para sus pobladores ribereños, fundamental para las pesquerías de subsistencia de la región, lo que ha llevado a su sobreexplotación. En este artículo se describen los aspectos reproductivos de P. magdalenae, en este embalse. Se realizaron diez muestreos de recolección mensuales, entre abril de 2018 y enero de 2019, con el fin de abarcar cada momento del pulso de inundación. Se calcularon la proporción sexual, relación gonadosomática (RGS), fecundidad, diámetro de ovocitos y talla media de madurez sexual (L50). Se analizaron 207 ejemplares, y se establecieron siete intervalos de tallas; 126 individuos fueron machos y 81 hembras, con una proporción sexual de 1:1.6 (hembra-macho). La RGS indicó que este pez tiene varios picos reproductivos, los principales en julio y septiembre. La fecundidad absoluta fue 1909 ovocitos para aguas bajando, 1590 para aguas bajas, 2435 para aguas subiendo y 2132 para aguas altas, con un diámetro promedio de ovocito de 0.29 mm. Los machos maduraron primero que las hembras y la L50 estuvo por debajo de la talla media de captura (30 cm), lo cual refleja que la normativa legal está bien determinada, pero no hay regulación para su pesca.
Reevaluation of the Seismogenic Fault of the 1654 M8.0 Tianshui Earthquake: Evidence from Geology, Geomorphology, and Chronology along the Lixian-Luojiapu Fault
Authors: Xie Chao , Wang Jinshuo , Pang Wei , He Siyuan , Bian Zongpan , Wang Yang , Zhou Bengang 
Published: October 2021

AbstractA historically documented M8.0 earthquake occurred in Tianshui, Gansu, China, in 1654. Its epicenter was located near the Lixian-Luojiapu fault in the triangular area at the conjunction of the Tibetan Plateau, North China block and South China block. Due to the lack of geologic and geomorphologic evidence and precise chronologic constraints, the seismogenic fault of this large event remains controversial. This work attempted to further address this issue. Based on data from unmanned aerial vehicle measurements, field investigations, analysis of typical fault profiles, and 14C dating, we determined the age of the latest slip on the Lixian-Luojiapu fault and the corresponding surface rupture range. In combination with historical earthquake data for this region, our work suggests that two sections of the Lixian-Luojiapu fault, the Tanchang-Lixian subsegment and the eastern portion of the Lixian-Luojiapu subsegment, were indeed involved in the surface rupturing of the 1654 Tianshui M8.0 earthquake. The scratches on the fault plane indicate that this seismic rupturing exhibited a left-lateral slip with a normal component and the maximum vertical displacement by this shock on the Tanchang-Lixian subsegment was 1.7±0.2 m. We suggest that the Tanchang-Lixian subsegment and the eastern portion of the Lixian-Luojiapu subsegment of the Lixian-Luojiapu fault and the West Qinling fault in the north jointly constituted the seismogenic structure of the Tianshui M8.0 earthquake based on a previous trench study. Located in the triangular zone between the Tibetan Plateau and the North China and South China blocks, tectonic stress accumulates rapidly on the Lixian-Luojiapu fault, resulting in a high potential of moderate to strong earthquakes, and this issue should be given more attention in the future.
Host-specific Signature Identification for Influenza A Using An Adjusted Entropy Measurement
Authors: Zhang Yixiang , Eskridge Kent M. , Zhang Shunpu , Lu Guoqing 
Published: October 2021

Abstract
Background. Influenza A viruses (IAV) exhibit vast genetic mutability and have great zoonotic potential to infect avian and mammalian hosts and are known to be responsible for a number of pandemics. A key computational issue in influenza prevention and control is the identification of molecular signatures with cross-species transmission potential. We propose an adjusted entropy-based host-specific signature identification method that uses a similarity coefficient to incorporate the amino acid substitution information and improve the identification performance.Results. Validation with a set of H5N1 PB2 sequences from 1996 to 2006 results in adjusted entropy having a 40% false negative discovery rate compared to an 80% false negative rate using unadjusted entropy. Simulations across a range of phenotypic divergence levels show a false negative rate of no higher than 10% while unadjusted entropy ranged from 9% to 100%. In addition, under all levels of divergence adjusted entropy never had a false positive rate higher than 9%. Adjusted entropy also identifies important mutations in H1N1pdm PB2 previously identified in the literature that explain changes in divergence between 2008 and 2009 which unadjusted entropy could not identify.Conclusions. Based on these results, adjusted entropy provides a reliable and widely applicable host signature identification approach useful for IAV monitoring and vaccine development.
Diversity of SAT2 Foot-and-Mouth Disease Virus in Sudan: Implication for Diagnosis and Control
Authors: Hussien Yazeed Raouf , Ibrahim Inas 
Published: October 2021

Abstract
Like other East African countries, Sudan experienced circulation of several SAT2 topotypes. In Sudan, topotype XIII and VII of SAT2 virus were recorded. This work meant to evaluate the impact of such diversity on diagnosis and control. A Sudanese SAT2 foot-and-mouth disease virus (FMDV) of topotype VII originated in 2010 showed poor antigenic relationship (r1 value ≈ 0.00) with Sudanese SAT2 FMDV from 2008 when topotype XIII was circulating. After one or three doses of a vaccine derived from SAT2 virus in 2010, heterologous antibody titres with SAT2 virus in 2008 were ≤ 1.2 log 10, not consistent with likely protection, while homologous titres were 1.65 (after one dose) or 1.95 and 2.55 log10 (after 3 doses). SAT2 positive field sera from Sudan in 2016 were not unvaryingly identified by virus neutralization tests (VNT) employing SAT2 viruses from 2010 and 2008. Proportions of positive sera by SAT2 virus from 2010 were always higher than those by viruses from 2008; consistent with the more frequent and recent circulation of topotype VII prior to 2016. Proportions by SAT2 virus from 2010 were 0.68 (±0.1) in one location (n=72), 0.39 (±0.1) in another one (n=94) and 0.52 (±0.1) in the whole test group (n=166). Corresponding values by viruses of 2008 were 0.53 (±0.1), 0.27 (±0.1) and 0.38 (±0.1). In the whole test group, differences were statistically significant (p=.02339). Like post-vaccination sera, field sera (natural immunity) showed no considerable cross neutralization between topotype VII and presumably XIII; almost 45% (43/96) of SAT2 positive field sera were positive to one topotype but not to the other. Experimental and surveillance findings emphasized the implication of SAT2 diversity in Sudan. It is concluded that it is difficult to control SAT2 infection in Sudan using a monovalent vaccine. Beside a prophylactic vaccine from topotype VII, stockpiling of antigens from topotype XIII and rapid genotyping and matching studies are necessary approaches. When more frequent circulation of more than one topotype occurs, retrospective diagnosis by serological surveys could be problematic or imprecise.
Classification of Obese and Healthy Children Based on Machine Learning Algorithms using Choroidal Thickness Features
Authors: Bulut Erkan , Koprubasi Sumeyra , Dayi Ozlem , Bulut Hatice 
Published: October 2021

Abstract
Purpose: To analyse the effect of macular choroidal thickness (MCT) and peripapillary choroidal thickness (PPCT) on the classification of obese and healthy children by comparing the performance of Random Forest (RF) or Support Vector Machine (SVM), and Multilayer Perceptrons (MLP) algorithms. Methods: 59 obese children and 35 healthy children aged 6 to 15 years were studied in this prospective comperative study using optical coherence tomography. MCT and PPCT were measured at 500 μm, 1000 μm, and 1500 μm distances from fovea and optic disc. Three different feature selection algorithms were used to determine the most prominent features of all extracted features. The classification efficiency of the extracted features was analyzed using RF, SVM, and MLP algorithms, demonstrating their efficacy for distinguishing obese from healthy children. The precision and reliability of measurements were assessed using Kappa analysis.Result: Correlation Feature Selection algorithm produced the most successful classification results among the different feature selection methods. The most prominent features for distinguishing the obese and healthy groups from each other were PPCT temporal 500 μm, PPCT temporal 1500 μm, PPCT nasal 1500 μm, PPCT inferior 1500 μm, and subfoveal MCT. The classification rates for RF, SVM, and MLP algorithms were 98.6%, 96.8% and 89%, respectively. Conclusion: Obesity-related metabolic alterations have an effect on the choriocapillaries of children, particularly in the subfoveal region and the outer semi-circle at 1500 μm from optic disc head. Both the RF and SVM algorithms are effective and accurate at classifying obese and healthy children.