bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Tunicate Swarm Algorithm for Solving Large-Scale Nonlinear Optimization Problems
Authors: Rizk-Allah Rizk M. , Saleh O. , Hagag Enas A. , Mousa Abd Allah A. 
Published: December 2021

AbstractNowadays optimization problems become difficult and complex, traditional methods become inefficient to reach global optimal solutions. Meanwhile, a huge number of meta-heuristic algorithms have been suggested to overcome the shortcomings of traditional methods. Tunicate Swarm Algorithm (TSA) is a new biologically inspired meta-heuristic optimization algorithm which mimics jet propulsion and swarm intelligence during the searching for a food source. In this paper, we suggested an enhancement to TSA, named Enhanced Tunicate Swarm Algorithm (ETSA), based on a novel searching strategy to improve the exploration and exploitation abilities. The proposed ETSA is applied to 20 unimodal, multimodal and fixed dimensional benchmark test functions and compared with other algorithms. The statistical measures, error analysis and the Wilcoxon test have affirmed the robustness and effectiveness of the ETSA. Furthermore, the scalability of the ETSA is confirmed using high dimensions and results exhibited that the ETSA is least affected by increasing the dimensions. Additionally, the CPU time of the proposed algorithms are obtained, the ETSA provides less CPU time than the others for most functions. Finally, the proposed algorithm is applied at one of the important electrical applications, Economic Dispatch Problem, and the results affirmed its applicability to deal with practical optimization tasks.
Edge Computing Using Embedded Webserver with Mobile Device for Diagnosis and Prediction of Metastasis in Histopathological Images
Authors: Johny Anil , Madhusoodanan K. N. 
Published: December 2021

AbstractDiagnosis of different breast cancer stages using histopathology whole slide images is the gold standard in grading the tissue metastasis. Traditional diagnosis involves labor intensive procedures and is prone to human errors. Computer aided diagnosis assists medical experts as a second opinion tool in early detection which prevents further proliferation. Computing facilities have emerged to an extent where algorithms can attain near human accuracy in prediction of diseases, offering better treatment to curb further proliferation. The work introduced in the paper provides an interface in mobile platform, which enables the user to input histopathology image and obtain the prediction results with its class probability through embedded web-server. The trained deep convolutional neural networks model is deployed into a microcomputer-based embedded system after hyper-parameter tuning, offering congruent performance. The implementation results show that the embedded platform with custom-trained CNN model is suitable for medical image classification, as it takes less execution time and mean prediction time. It is also noticed that customized CNN classifier model outperforms pre-trained models when used in embedded platforms for prediction and classification of histopathology images. This work also emphasizes the relevance of portable and flexible embedded device in real time clinical applications.
Easy Access to Antibiotics; Spread of Antimicrobial Resistance and Implementation of One Health Approach in India
Authors: Jani Kunal , Srivastava Vibhaw , Sharma Preeti , Vir Aruna , Sharma Avinash 
Published: December 2021

AbstractAntimicrobial resistance (AMR) is a global public health concern because of its fast spread. India, one of the world’s top consumer of antibiotics and second most populated country has its unique constraints of social, cultural and economic strata. The continual self-medication, use of antibiotics for the growth promotion in animals, and accumulation of residual antibiotics in the environment challenge the implementation of AMR containment policy. Hence, the present review attempts to delineate the influence of antibiotics abuse on the human, animal and environmental health under the realm of one health. It was based on the literature search using public databases to highlight the rapid surge in the burden of AMR in India affecting various sectors and/or ecosystems in India. It was found that the irrational and overuse of antibiotics in different sectors have led to the emergence of extended antimicrobial resistance wherein the environment acts as a reservoir of antibiotic resistance genes (ARGs); completing the cycle of contamination and recontamination. There are efforts by government policy makers to reduce the burden of AMR in the country to reduce the health risks, through the One Health approach. Parallel efforts in educating healthcare professionals, strict legislation for pharmacies and pharmaceutical companies should be prioritize. At the same time surveillance of newly emerged AMR pathogens, prioritising research focusing on AMR, and awareness camps or programs among the local population is critical while addressing the consequences of spared of AMR in India.
A Test for Multiple Binary Endpoints with Continuous Latent Distribution in Clinical Trials
Authors: Ishihara Takuma , Yamamoto Kouji 
Published: December 2021

AbstractIn clinical trials, two or more binary responses obtained by dichotomizing continuous responses are often employed as multiple primary endpoints. Testing procedures for multiple binary variables with latent distribution have not yet been adequately discussed. Based on the association measure among latent variables, we provide a statistic for testing the superiority of at least one binary endpoint. In addition, we propose a testing procedure with a framework in which the trial efficacy is confirmed only when there is superiority of at least one endpoint and non-inferiority of the remaining endpoints. The performance of the proposed procedure is evaluated through simulations.
Current antimicrobial prescription at outpatient dentistry centers and clinics in tertiary-care hospitals in Tokyo, Japan: A multicenter cross-sectional study
Authors: Tagashira Yasuaki , Horiuchi Masao , Kosaka Atsushi , Washino Takuya , Horiuchi Mikihiro , Murakami Shutaro , Tagashira Itoe , Honda Hitoshi 
Published: December 2021

Abstract

Background:
Antimicrobial administration is necessary before specific dental procedures to prevent postprocedural infections and complications and antimicrobials are sometimes indicated for the treatment of odontogenic infections. However, antimicrobials are commonly misused by dentists.

Methods:
This cross-sectional study was conducted at 4 public, tertiary-care hospitals in Tokyo, Japan, from June to July 2019. We included patients who received an antimicrobial prescription at the outpatient dentistry center or clinic at each participating hospital. The indications for antimicrobial prescription were (1) antimicrobial prescriptions for prophylaxis (APPs) or (2) antimicrobial prescriptions for treatment (APTs). Prescribing patterns were described in terms of antimicrobial choice, timing, and dosages for APPs and APTs.

Results:
During the study period, 1,772 patients received an antimicrobial prescription. Among them 1,439 (81.2%) were APPs and 333 (18.8%) were APTs. The most common aim of APP was to prevent local infections and complications following tooth extraction (n = 1,244, 86.4%). The proportion of appropriate APPs was only 0.8% (12 of 1,439). Among 1,439 total APPs, 171 (11.9%) were unnecessary, 32 (2.2%) were inappropriate, and 1,224 (85.1%) were suboptimal. Whereas 101 (30.3%) of 333 APTs were appropriate, the remaining 97 instances (29.1%) were unnecessary, 86 (26.7%) were inappropriate, and 46 (13.8%) were suboptimal.

Conclusion:
Inappropriate antimicrobial prescriptions were common among dentists in Japan. Understanding the differences in the current antimicrobial prescribing patterns for prophylaxis and treatment is critically important for implementing an effective antimicrobial stewardship program in dentistry.
Atypical symptom reporting after mild traumatic brain injury
Authors: Sullivan Karen , Keyter Anna , Jones Kelly , Ameratunga Shanthi , Starkey Nicola , Barker-Collo Suzanne , Webb James , Theadom Alice 
Published: December 2021

AbstractObjective:Early reporting of atypical symptoms following a mild traumatic brain injury (mTBI) may be an early indicator of poor prognosis. This study aimed to determine the percentage of people reporting atypical symptoms 1-month post-mTBI and explore links to recovery 12 months later in a community-dwelling mTBI sample.Methods:Adult participants (>16 years) who had experienced a mTBI were identified from a longitudinal incidence study (BIONIC). At 1-month post-injury, 260 participants completed the Rivermead Post-Concussion Symptoms Questionnaire (typical symptoms) plus four atypical symptom items (hemiplegia, difficulty swallowing, digestion problems and difficulties with fine motor tasks). At 12 months post-injury, 73.9% (n = 193) rated their overall recovery on a 100-point scale. An ordinal regression explored the association between atypical symptoms at 1 month and recovery at 12 months post-injury (low = 0–80, moderate = 81–99 and complete recovery = 100), whilst controlling for age, sex, rehabilitation received, ethnicity, mental and physical comorbidities and additional injuries sustained at the time of injury.Results:At 1-month post-injury <1% of participants reported hemiplegia, 5.4% difficulty swallowing, 10% digestion problems and 15.4% difficulties with fine motor tasks. The ordinal regression model revealed atypical symptoms were not significant predictors of self-rated recovery at 12 months. Older age at injury and higher typical symptoms at 1 month were independently associated with poorer recovery at 12 months, p < 0.01.Conclusion:Atypical symptoms on initial presentation were not linked to global self-reported recovery at 12 months. Age at injury and typical symptoms are stronger early indicators of longer-term prognosis. Further research is needed to determine if atypical symptoms predict other outcomes following mTBI.
Anthelmintic activity ofStevia multiaristataextract againstEchinococcus granulosus sensu stricto
Authors: Albani C. M. , Borgo J. , Fabbri J. , Pensel P. , Fasciani L. , Elso O. , Papademetrio D. , Grasso D. , Paladini A. , Beer M. F. , Farias N. E. , Elissondo N. , Gambino G. , Zoppi J. , Sülsen V. , Elissondo M. C. 
Published: December 2021

AbstractCystic echinococcosis is a zoonotic disease caused by the larval stage of the parasiteEchinococcus granulosus sensu lato. The available anti-parasitic treatment is mostly limited to a continuous administration of albendazole. However, due to its numerous side-effects and efficacy of around 50%, there is a need to find new drugs to improve the treatment for this disease. In the current study, thein vitroandin vivoefficacy of aStevia multiaristataextract againstE. granulosus sensu stricto(s.s.) was demonstrated.Stevia multiaristataextract (100 and 50μg mL−1) caused a quick viability decrease on protoscoleces which was consistent with the observed tegumental alterations. Loss of turgidity was detected in 95 ± 3.4% of cysts incubated withS. multiaristataextract during 2 days (100μg mL−1) and the collapse of the germinal layer was observed in 60 ± 9.3% of cysts treated with 100μg mL−1of theS. multiaristataextract during 4 days. The half maximal effective concentration value was 69.6μg mL−1and the selectivity index forE. granulosus s.s.cysts was 1.9. In this clinical efficacy study, the treatment of infected mice with theS. multiaristataextract (50 mg kg−1) caused a significant decrease in the weight of the cysts compared with the control group. These results coincided with the tissue damage observed in the cysts at the ultrastructural level. In conclusion, we observed high protoscolicidal and cysticidal effects, and significant reduction in the weight of the cysts in experimentally infected mice following treatment with theS. multiaristataextract.
Two multistate outbreaks of a reoccurring Shiga toxin-producing Escherichia coli strain associated with romaine lettuce: USA, 2018–2019
Authors: Waltenburg Michelle A. , Schwensohn Colin , Madad Asma , Seelman Sharon L. , Peralta Vi , Koske Sarah E. , Boyle Michelle M. , Arends Katherine , Patel Kane , Mattioli Mia , Gieraltowski Laura , Neil Karen P. ,   Outbreak Investigation Team
Published: December 2021

Abstract
Leafy green vegetables are a common source of Shiga toxin-producing Escherichia coli O157:H7 (STEC O157) foodborne illness outbreaks. Ruminant animals, primarily cattle, are the major reservoir of STEC O157. Epidemiological, traceback and field investigations were conducted to identify potential outbreak sources. Product and environmental samples were tested for STEC. A reoccurring strain of STEC O157 caused two multistate outbreaks linked to romaine lettuce in 2018 and 2019, resulting in 234 illnesses in 33 states. Over 80% of patients interviewed consumed romaine lettuce before illness. The romaine lettuce was sourced from two California growing regions: Santa Maria and Salinas Valley in 2018 and Salinas Valley in 2019. The outbreak strain was isolated from environmental samples collected at sites >90 miles apart across growing regions, as well as from romaine-containing products in 2019. Although the definitive route of romaine contamination was undetermined, use of a contaminated agricultural water reservoir in 2018 and contamination from cattle grazing on adjacent land in 2019 were suspected as possible factors. Preventing lettuce contamination from growth to consumption is imperative to preventing illness. These outbreaks highlight the need to further understand mechanisms of romaine contamination, including the role of environmental or animal reservoirs for STEC O157.
Contextual risks, child problem-solving profiles, and socioemotional functioning: Testing the specialization hypothesis
Authors: Li Zhi , Sturge-Apple Melissa L. , Davies Patrick T. 
Published: December 2021

AbstractGuided by the evolutionary perspective and specialization hypothesis, this multi-method (behavioral observation, questionnaire) longitudinal study adopted a person-centered approach to explore children’s problem-solving skills within different contexts. Participants were 235 young children (M age = 2.97 years at the first measurement occasion) and their parents assessed in two measurement occasions spaced one year apart. Latent profile analyses revealed four unique problem-solving profiles, capturing variability in children’s performance, and observed engagement in abstract vs. reward-oriented (RO) problem-solving tasks at wave one. The four profiles included: (a) a high-abstract-high-RO, (b) a high-abstract-low-RO, (c) a low-abstract-high-RO, and (d) a low-abstract-low-RO classes. Contextual risks within and outside families during wave one, including greater neighborhood crime, impoverishment, and observed lower maternal sensitivity were linked to the elevated likelihood for children from the two profiles with low-abstract problem-solving, particularly those from the low-abstract-high-RO problem-solving profile. Furthermore, child problem-solving profiles were linked to meaningful differences in their socioemotional functioning one year later. The present finding has important implications in revealing the heterogeneity in child problem-solving within different contexts that responded differently to contextual risks. In addition, this study advanced the understanding of the developmental implications of child problem-solving capacity.
Status and habitat description of the globally threatened Udzungwa Forest PartridgeXenoperdix udzungwensisthirty years after discovery
Authors: DINESEN LARS , JENSEN FLEMMING PAGH , SONNE JESPER , LEVINSKY IRINA , MULUNGU ELIA 
Published: December 2021

SummaryThe Udzungwa Forest PartridgeXenoperdix udzungwensiswas discovered in 1991 in the geologically old and eco-climatically stable Udzungwa Mountains (hereafter the Udzungwas) in Tanzania - a global biodiversity hotspot in the Eastern Arc Mountains of East Africa. The partridge is categorised as globally ‘Endangered’ and this study aims at assessing its population status and habitat requirements in the two separate montane forests where it was discovered c.30 years ago and for the first time using systematic playback technique. We estimate the partridge population at c.2,800 individuals (1,680–3,860) confined to less than 150 km2and now confined to a single forest and with a clearly declining distribution within the last few decades since its discovery. The species is confined to evergreen closed (semi-closed) canopy forest habitat with leaf litter and sedges on the forest floor for feeding and cover. The partridge has become an emblem for the high concentration of endemic species of the Udzungwa Mountains National Park. At the same time there is a risk that this species could go extinct without notice if the Tanzanian authorities do not tackle two envisaged main drivers, namely fragmentation of the evergreen forest area over the last few centuries and current illegal hunting. Hence it seems crucial to allow natural expansion of its forest habitat in the Udzungwas and to eliminate hunting in the other forest within its recently known distribution where the population has presumably been extirpated. The partridge is remarkable as its closest relatives are in South-east Asia and it is used as a flagship species for the Udzungwas, which has one of the highest concentrations of endemic species on earth.
Importation of plastic fragments into a seabird colony: accident or design, threat or benign?
Authors: VAN DE CROMMENACKER JANSKE , SOARES JOANNA H. , LAROSE CHRISTINE S. , FEARE CHRIS J. 
Published: December 2021

SummaryPlastic pollution affects marine ecosystems worldwide and poses risks for seabirds. Most recorded impacts on organisms are negative but, in some cases, the constructive use of plastic fragments or objects by birds has also been recorded. Small blue and green plastic fragments are found scattered among nests in a large (c.500,000 pairs) Sooty Tern Onychoprion fuscatus nesting colony on Bird Island, Seychelles. We investigated whether the fragments were being imported by the birds, and if so whether import was accidental or intentional. We found that Sooty Terns were the only seabird species to have plastic fragments in their nesting area and import of fragments varied seasonally and spatially. Throughout the colony, plastic fragments were imported during egg-laying, incubation, and chick-rearing, but import declined as chicks began to fledge. A part of the colony where all eggs were harvested for human consumption received more fragments than among undisturbed nests. We failed to find evidence of ingestion and excretion of fragments and suggest other avenues for investigation.
How to Build Your Own ASP-based System?!
Authors: KAMINSKI ROLAND , ROMERO JAVIER , SCHAUB TORSTEN , WANKO PHILIPP 
Published: December 2021

AbstractAnswer Set Programming, or ASP for short, has become a popular and sophisticated approach to declarative problem solving. Its popularity is due to its attractive modeling-grounding-solving workflow that provides an easy approach to problem solving, even for laypersons outside computer science. However, in contrast to ASP’s ease of use, the high degree of sophistication of the underlying technology makes it even hard for ASP experts to put ideas into practice whenever this involves modifying ASP’s machinery. For addressing this issue, this tutorial aims at enabling users to build their own ASP-based systems. More precisely, we show how the ASP system clingo can be used for extending ASP and for implementing customized special-purpose systems. To this end, we propose two alternatives. We begin with a traditional AI technique and show how metaprogramming can be used for extending ASP. This is a rather light approach that relies on clingo’s reification feature to use ASP itself for expressing new functionalities. The second part of this tutorial uses traditional programming (in Python) for manipulating clingo via its application programming interface. This approach allows for changing and controlling the entire model-ground-solve workflow of ASP. Central to this is clingo’s new Application class that allows us to draw on clingo’s infrastructure by customizing processes similar to the one in clingo. For instance, we may apply manipulations to programs’ abstract syntax trees, control various forms of multi-shot solving, and set up theory propagators for foreign inferences. A cross-sectional structure, spanning meta as well as application programming, is clingo’s intermediate format, aspif, that specifies the interface among the underlying grounder and solver. We illustrate the aforementioned concepts and techniques throughout this tutorial by means of examples and several nontrivial case studies. In particular, we show how clingo can be extended by difference constraints and how guess-and-check programming can be implemented with both meta and application programming.
Modalities of Assimilation: Subcultural Currents in Felix Mendelssohn's Lieder Ohne Worte
Authors: Deutsch Dan 
Published: December 2021

In this article I examine the impact of Felix Mendelssohn's affiliation with a German-Jewish subculture on his music as reflected in the Lieder ohne Worte (Songs without Words) for piano solo. To better understand the interrelationship between musical formations and sociocultural realities, I associate the real and imaginary tensions between the German, the Jewish, and the German-Jewish with stylistic ambiguities in Mendelssohn's piano songs, which often destabilize the lyrical simplicity projected by the lieder framework through formal complexities that exceed the narrow scope of the piano miniature.I establish the connections between Mendelssohn's music and sociocultural disposition by identifying a correlation between his so-called stylistic ‘conservatism’ and the anachronistic devotion of German Jewry to the universal ideals of the Enlightenment during the rise of German nationalism. Against this background, I primarily reveal the generic heterogeneity of the Lieder ohne Worte, which feature ‘progressive’ stylistic frameworks associated with the lied traditions yet concurrently point toward the formal ideals of eighteenth-century classicism. And following this, I position the stylistic duality of Mendelssohn's piano songs within a broader context through Heinrich Heine's essay The Romantic School, which sheds crucial light on the negotiation of Jewishness within German culture as it is reflected in aesthetic movements, historical changes, and political climates.
Illuminating a Contorted Slab With a Complex Intraslab Rupture Evolution During the 2021 Mw 7.3 East Cape, New Zealand Earthquake
Authors: Okuwaki Ryo , Hicks Stephen P. , Craig Timothy J. , Fan Wenyuan , Goes Saskia , Wright Tim J. , Yagi Yuji 
Published: December 2021

AbstractThe state‐of‐stress within subducting oceanic plates controls rupture processes of deep intraslab earthquakes. However, little is known about how the large‐scale plate geometry and the stress regime relate to the physical nature of the deep intraslab earthquakes. Here we find, by using globally and locally observed seismic records, that the moment magnitude 7.3 2021 East Cape, New Zealand earthquake was driven by a combination of shallow trench‐normal extension and unexpectedly, deep trench‐parallel compression. We find multiple rupture episodes comprising a mixture of reverse, strike‐slip, and normal faulting. Reverse faulting due to the trench‐parallel compression is unexpected given the apparent subduction direction, so we require a differential buoyancy‐driven stress rotation, which contorts the slab near the edge of the Hikurangi plateau. Our finding highlights that buoyant features in subducting plates may cause diverse rupture behavior of intraslab earthquakes due to the resulting heterogeneous stress state within slabs.