bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEER COUNSELING TRAINING AS A METHOD OF SEXUAL HEALTH PROMOTION IN ADOLESCENTS
Authors: Isni Khoiriyah 
Published: August 2021

ABSTRACT One characteristic of adolescents is their tendency to share information, tell stories, and gather with their peers. They may experience the negative effects of these habits when they do not have adequate life skills, especially in terms of sexuality. On the other hand, these activities present an opportunity for health promotion through peer-based approaches or peer counseling. The goal is to know the effects of peer counseling methods as media of information to increase adolescents’ knowledge and attitude regarding sexual problems. The study used a quasi-experimental approach with a nonequivalent control group design. The sample consisted of 17 respondents between 15-24 years old living in Banguntapan, Bantul, Yogyakarta who fulfilled the inclusion and exclusion criteria. Data were collected with the purposive sampling technique. The research instrument used was a questionnaire. The results showed that there was a difference in the average knowledge level (p = 0.021) and attitudes (p = 0.000) of respondents related to sexuality before and after receiving peer counseling training. Methods and media used in delivering health information to adolescents should be diversified in schools, in the community, and in health services to generate interest in accessing and heeding appropriate health information. Keywords: peer counseling, sexuality, adolescents, health promotion
IMPLEMENTATION OF WATER SUPPLY SUPERVISION IN CLASS 1 PORT HEALTH OFFICE IN JUANDA AIRPORT WORKING AREA, SURABAYA
Authors: Nugrahanik Rizky , Utomo Bangun Cahyo 
Published: August 2021

ABSTRACTThe provision of clean water in the Class 1 Surabaya Port Health Office is supervised in accordance with the existing regulations to identify sources that could potentially cause pollution and prevent the occurrence of illness caused by unstandardized water quality and unsafe water supply. This study aimed to describe the implementation of clean water supply supervision in the Class 1 Surabaya Port Health Office in the Juanda Airport working area, Surabaya. This was an observational study which analysis was descriptive in nature. The clean water was tested for physical, chemical, and microbiological parameters, and the results showed that the water quality was in accordance with the Regulation of the Indonesian Ministry of Health No. 416 of 1990 about the Terms and Monitoring of Water Quality. However, the result from the simple chemical inspection test of the water showed that it did not fulfil health standards i.e., the residual chlorine score not equal to 0 (zero). It is suggested that more attention and supervision are conducted by water management authorities to ensure the standard residual chlorine level of 0 (zero). Additionally, expired reagents or reagents that have already changed color should not be used as it will affect the parameters tested. Keywords: Quality of clean water, clean water supply facilities, water sampling process
EVALUATING TOBACCO ADVERTISING VIOLATIONS AND IT’S CONTRIBUTION TO LOCAL REVENUE IN MAKASSAR
Authors: Hamdani Musyarrafah , Wahyuni Sri , Sultan Ismi , Maidin M. Alimin , Wadi Ahmad , Hasyim Hadijah , Shabir Achmad Mawardi 
Published: August 2021

ABSTRACT Around 50.82% of the age group 15-19 years were smokers in Makassar city, one of which was influenced by tobacco ads exposure (National Institute of Health Research and Development, 2019b). This study aimed to evaluate the violation of tobacco product advertising to Local Regulation of South Sulawesi No. 1 of 2015 on Smoke-Free Area (SFA) in 2019 and its contribution to local revenue of Makassar City in 2018. This was a descriptive study through a quantitative approach with cross sectional design. The observation was conducted on 21 major roads and the document review was performed by processing and analyzing the secondary data of the Regional Revenue Department of Makassar City 2018. Data were analyzed descriptively using IBM SPSS 22. This study found around 51% of 619 tobacco advertising (banner, billboard, name board, poster, pushcart, and video Tron) did not comply with the Local Regulation of South Sulawesi 1/2015. The violations were located in SFA (2%); near schools and healthcare facilities (14%); cut off the roads (16%); the size >72 m2 (6%); and near government offices (40%). The contribution of tobacco advertising was only IDR 736,643,634,-., which was around 0.02% of the local revenue. The violation of tobacco advertising to the Local Regulation 1/2015 and a very small contribution to local revenue showed that Mayor Regulation on Total Tobacco Advertising, Promotion, and Sponsorship (TAPS) Ban should be carried out immediately to prevent children to be the target tobacco industries in Makassar City.Keywords: tobacco advertising, TAPS contribution, local revenue
Analisis Kolaborasi Apoteker dan Dokter di Puskesmas Surabaya dari Pespektif Dokter
Authors: Gloria Fransisca , Pristianty Liza , Rahem Abdul 
Published: August 2021

Pendahuluan: Diabetes melitus adalah penyakit yang kompleks, suatu penyakit kronis yang membutuhkan perawatan medis terus menerus (kontinyu). Untuk meningkatkan hasil klinis pasien dan keberhasilan dalam terapi diperlukan suatu kolaborasi interprofesi. Tujuan: Penelitian ini menganalisis kolaborasi dokter dan apoteker di Puskesmas se-kota Surabaya khususnya dalam menangani terapi pasien diabetes melitus dari perspektif dokter. Metode: Desain penelitian cross sectional. Penelitian dilakukan dalam waktu 3 bulan di 63 Puskesmas kota Surabaya dengan responden 63 dokter. Instrumen yang digunakan “Kuesioner Kolaborasi Dokter” yang meliputi variabel bebas (karakteristik pertukaran dengan domain kepercayaan, hubungan inisiasi dan peran spesifikasi) dan variabel terikat (praktik kolaborasi). Analisis data menggunakan analisis nonparametric dengan korelasi Rank Spearman Test untuk mengetahui hubungan antara variabel karakteristik pertukaran. Hasil: Hasil analisis data menunjukkan bahwa terdapat hubungan yang signifikan (p = 0,000) antara masing-masing dari ketiga domain dengan praktik kolaborasi (collaborative practice) dokter dan apoteker. Hubungan inisiasi dokter merupakan domain yang memiliki pengaruh yang paling kuat terhadap praktik kolaborasi, diikuti domain peran spesifikasi dan kepercayaan. Kesimpulan: Ketiga domain dalam CWR memengaruhi praktik kolaborasi, namun dibutuhkan informasi lebih lanjut mengenai implementasi kolaborasi antara dokter dan apoteker di Puskesmas dalam penanganan pasien diabetes melitus serta perspektif apoteker mengenai praktik kolaborasi dengan dokter.
Paleogeography of the West Siberian Sedimentary Basin in the Late Bajocian–Bathonian
Authors: Kazanenkov V.A. 
Published: August 2021

Abstract
—The paper presents results of regional paleogeographic reconstructions of the West Siberian sedimentary basin in the Late Bajocian–Bathonian. Regional paleogeographic maps of the Yu4, Yu3 and upper part of the Yu2 reservoir units were constructed and described for the first time ever. The implemented approach provided insights into the evolution of paleolandscapes and highlighted the deposition features of the Upper Tyumen Subformation and Malyshev Formation in the different parts of the West Siberian basin. The compilation of paleogeographic maps was based on the electrofacies analysis performed for individual parts of the Malyshev stratigraphic horizon, with regard to the core description materials, paleontological, sedimentological, geochemical data and other. The paleogeographic control of the reservoir’s formation in the Bathonian regional reservoir is discussed.
The Theory of Naphthidogenesis: A Quantitative Model of the Catagenetic Evolution of Aquatic Organic Matter
Authors: Kontorovich A.E. , Burshtein L.M. , Livshits V.R. 
Published: August 2021

Abstract
—This study discusses the evolution of the composition of dispersed organic matter from the Bazhenov Formation (West Siberian petroleum basin) and the products of its catagenetic transformation on the basis of the balance and kinetic approaches to modeling of the catagenetic transformation of organic matter and its individual components, primarily kerogen. The results show that the variations in the elemental composition of kerogen and the extent of generation of both hydrocarbons and nonhydrocarbons can be quantitatively described using a simplified kinetic model. Preliminary estimates of the model parameters are given for the averaged Bazhenov-type kerogen. It is shown that numerical modeling of the catagenetic transformation of dispersed organic matter confirms the validity of the recognition of the main phase (zone) of oil generation and the main phase (zone) of gas generation.
Technology Focus: Reservoir Simulation (July 2021)
Authors: Burgoyne Mark 
Published: August 2021

In reviewing the long list of papers this year, it has become apparent to me that the hot topic in reservoir simulation these days is the application of data analytics or machine learning to numerical simulation and with it quite often the promise of data-driven work flows—code for needing to think about the physics less.
Data-driven work flows have their place, especially when we have a lot of data and the system is very complex. I’m thinking shales especially, but seeing it being applied to more conventional reservoirs gave me a moment of pause.
I can’t help but think that, in terms of the hype cycle as related to the application of machine learning to numerical simulation, we may be approaching the peak of inflated expectations. I say “approaching,” because many companies appear to be dipping their toes in the water, perhaps because they think they should, but few are truly committing to it. Many vocal champions of the approach exist, but most decision-makers just don’t understand it yet.
If we cannot explain how something works simply, then thoughtful leaders will tend not to trust it. Whether it be numerical-simulation findings or self-organizing neural networks, the need will always exist for a deep understanding and clarity of explanation of both the discipline and method used. To decision-makers, it will be an attractive concept, but they will generally ask to validate against more traditional methods.
I look forward to a future when we are through the trough of disillusionment and start climbing the slope of enlightenment to a new level of productivity. I suspect, though, that it will take at least another 5 years, as our current crop of knowledgeable evangelists become decision-makers themselves and can put in place work flows and teams to leverage the approach appropriately for their problems, intelligently leveraging their years of hard-won experience.
I will lay a wager with you, though, that when that time comes, those new ways of working more efficiently will rely just as much if not more upon a deep understanding of reservoir engineering as our current methods.
I hope you enjoy these papers, which include examples of both the new approach as well as tried-and-true approaches.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 202436 - Fast Modeling of Gas Reservoirs Using Proper Orthogonal Decomposition/Radial Basis Function (POD/RBF) Nonintrusive Reduced-Order Modeling by Jemimah-Sandra Samuel, Imperial College London, et al.
IPTC 21417 - A New Methodology for Calculating Wellbore Shut-In Pressure in Numerical Reservoir Simulations by Babatope Kayode, Saudi Aramco, et al.
SPE 201658 - Mechanistic Model Validation of Decline Curve Analysis for Unconventional Reservoirs by Mikhail Gorditsa, Texas A&M University, et al.
Extended Reach Drilling with Coiled Tubing: A Case Study on the Alaskan North Slope That Proves the Benefits of Drilling a Straight Hole
Authors: Miszewski Antoni , Miszewski Adam , Stevens Richard , Gemignani Matteo 
Published: August 2021

Summary
A set of five wells were to be drilled with directional coiled tubing drilling (CTD) on the North Slope of Alaska. The particular challenges of these wells were the fact that the desired laterals were targeted to be at least 6,000 ft long, at a shallow depth, almost twice the length of laterals that are regularly drilled at deeper depths. The shallow depth meant that two of the five wells involved a casing exit through three casings, which had never been attempted before. After drilling, the wells were completed with a slotted liner, run on coiled tubing (CT). This required a very smooth and straight wellbore so that the liner could be run as far as the lateral had been drilled. In this paper, we focus on one of the two wells on which triple casing exit was performed. However, the same considerations and results apply to the other wells on which the same technology has been used.
Various methods were considered to increase lateral reach, including running an extended reach tool, using a friction reducer, increasing the CT size, and using a drilling bottomhole assembly (BHA) that could drill a very straight well path. All of these options were modeled with tubing forces software, and their relative effectiveness was evaluated.
The drilling field results easily exceeded the minimum requirements for success. This project demonstrated record-breaking lateral lengths, a record length of liner run on CT in a single run, and a triple casing exit. The data gained from this project can be used to fine-tune the modeling for future work of a similar nature.
The Impact of Early Achievement of Therapeutic Levels of Vancomycin in Critically ill Patients with Confirmed Gram-positive Infection: A Retrospective Cohort Study
Authors: Sulaiman Khalid Al , Alshaya Abdulrahman , Alsaeed Amjad , Alshehri Nadiyah , Vishwakarma Ramesh , Alzahrani Hamdan , Harbi Shmeylan Al 
Published: August 2021

Abstract
Background: Vancomycin is a commonly used antibiotic in critically ill patients for various indications. Critical illness imposes pharmacokinetic-pharmacodynamics challenges which makes optimizing vancomycin in this population cumbersome. Data are scarce on the clinical impact of time to therapeutic trough levels of vancomycin in critically ill patients. The aim of this study to evaluate the timing to achieve therapeutic trough level vancomycin on 30-day mortality in critically ill patients.Method: A retrospective cohort study for all adult critically ill patients aged 18 years or older with confirmed Gram-positive infection and received vancomycin between January 1st, 2017 and December 31st, 2018 at a tertiary teaching hospital. We compared early (<48 hours) versus late (≥ 48 hours) attainment of vancomycin therapeutic trough levels. Primary outcome was the 30-day mortality in critically ill patients. Secondary outcomes were development of resistant organisms, eradicating microorganisms within 4-5 days of vancomycin initiation, vancomycin-induced acute kidney injury (AKI), and ICU length of stay (LOS). Results: Two hundred and nine patients were included. No significant differences between comparative groups in baseline characteristics. Achieving therapeutic levels were associated with better survival at 30 days (OR: 0.48; 95% CI [0.26-0.87]; p<0.01). Additionally, patients who achieved therapeutic levels of vancomycin early were less likely to develop resistant organisms (OR=0.08; 95% CI [0.01-0.59]; p=0.01). The AKI and ICU LOS were not significant between the two groups.Conclusion: Early attainment of vancomycin therapeutic levels was associated with possible survival benefit.
Rhamnocitrin Ameliorates Ovarian Fibrosis Via PPARγ/TGF-β1/Smad Pathway to Repair Ovarian Function in Polycystic Ovary Syndrome Rats Running Title：rhamnocitrin Ameliorates Ovarian Fibrosis in Polycystic Ovary Syndrome Rats
Authors: Zhou Yanyuan , He Chunhua , Dong Zhewen , Lan Huan , Chong Chaojie , Song Jiale 
Published: August 2021

Abstract
Background: Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders in women, characterized by androgen excess, chronic anovulation and ovarian fibrosis. Rhamnocitrin is an herbal bioactive flavonoid that has anti-inflammation and antioxidant effects. We intended to investigate the impacts of Rhamnocitrin on PCOS-induced ovarian fibrosis and its underlying mechanisms.Methods: Dehydroepiandrosterone (DHEA) induced-PCOS rats were treated with Rhamnocitrin. HE staining was performed to detect ovarian histological features. Ovarian fibrosis was evaluated by Sirius Red and Masson staining. Vaginal smear was examined to exhibit estrus cycle stage and vaginal cornification. The serum hormone levels of FSH, LH, E2 and T were measured with ELISA. The related mRNAs and proteins of fibrosis factors and PPARγ/TGF-β1/Smad2 signaling were detected by RT-qPCR and western blot. The weights of rat bodies and ovaries were recorded. PPARγ inhibitor T0070907 and its agonist GW1929 were employed for the mechanistic investigation.Results: The corpus luteum and follicles were increased and irregular estrous cycle was restored after Rhamnocitrin treatment in PCOS rats. Rhamnocitrin inhibited ovarian fibrosis and down-regulated the expressions of fibrotic factors. Rhamnocitrin reduced the increased levels of LH, E2, and T, and elevated the decreased FSH level in PCOS rats. Besides, Rhamnocitrin elevated the down-regulated PPARγ, and suppressed the up-regulated TGF-β1 and p-Smad2 expressions induced by PCOS. These effects of Rhamnocitrin on PCOS rats could be antagonized by T0070907, whereas GW1929 markedly mimics the functions of Rhamnocitrin. Conclusions: Rhamnocitrin ameliorates ovarian fibrosis in PCOS rats through regulation PPARγ/TGF-β1/Smad2pathway, suggesting it can be a potentially effective therapeutic candidate for PCOS treatment.
Identifying Network Biomarkers of Cancer By Sample-Specific Differential Network
Authors: Zhang Yu , Chang Xiao , Xia Jie , Huang Yanhong , Sun Shaoyan , Chen Luonan , Liu Xiaoping 
Published: August 2021

Abstract
Abundant datasets generated from various big science projects on diseases have presented great challenges and opportunities, which are contributed to unfold the complexity of diseases. The discovery of disease- associated molecular networks for each individual plays an important role in personalized therapy and precision treatment of cancer based on the reference networks. However, there are no effective ways to distinguish the consistency of different reference networks. In this study, we developed a statistical method, i.e. a sample-specific differential network (SSDN), to construct and analyze such networks based on gene expression of a single sample against a reference dataset. We proved that the SSDN is structurally consistent even with different reference datasets if the reference dataset can follow certain conditions. The SSDN also can be used to identify patient-specific disease modules or network biomarkers as well as predict the potential driver genes of a tumor sample.
Antioxidants Supplementation In Acute Amitriptyline Abuse for Pain
Authors: S Hameed Kadar Ali , K Wasim Ali Raja , Navabshan IRFAN , Habeeb Mohammad , Y Ismail 
Published: August 2021

Abstract
The fundamental aim of this study is to establish the role of anti-oxidant supplementation in alleviating acute amitriptyline induced oxidative stress. The effect of supplementation was compared on treatment of acute amitriptyline intoxication cases for pain management, with Alpha lipoic acid (ALA) alone or with vitamin C, with that of healthy individuals (Group I), and those receiving only routine standard treatment (RST) as control (Group II). Total of 132 human subjects divided into 5 groups were supplemented with either placebo, RST, RST with Vitamin C, RST with ALA, or RST with Vitamin C and ALA. Results of this study revealed that the decrease in the level of oxidative stress and enzyme activity was observed among those supplemented with either Alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in the latter group. P value < 0.001 was considered statistically significant. The percentage of benefit of treatment on supplementation with vitamin C and Alpha lipoic acid showed a marked increase in-group V cases after supplementation with both in combination. The results provided that the oxidative stress induced by acute amitriptyline poisoning is comparatively decreased by supplementation with antioxidants like Alpha lipoic acid and Vitamin C, than those only on routine standard treatment.
Comparison of Electrical Characterization of AlGaN/GaN HEMT with Multi-finger Gate
Authors: He Lijun , Zhao Boyang , He Chengyun , Xie Zhiyang , Long Xing , Zhang Zhaopeng , Qi Fei 
Published: August 2021

Abstract
This paper presents an exhaustive TCAD based comparison of the multi-gate and T-gate AlGaN/GaN HEMT. This paper simulates the DC and RF characteristics of the device and makes an accurate comparison. The important feature of the device such as threshold voltage, drain current output characteristics, transconductance, cut-off frequency, and maximum oscillation frequency were obtained. It is concluded that the shape optimization of the HEMT with multi-finger gates and the advantages over traditional T-gate devices. The device of two-finger gate with 50nm spacing has the best output characteristics, and its maximum saturation current is about 110% the size of the device of four-finger gate with 200nm at VGS=0V. And the gm and the gain of the device with 50nm spacing two-finger gate is 76mS/mm larger than the HEMT of three-finger gate with 200nm. In addition, we also conducted a simulation in the case of changing only refers to finger-gate length and cap-gate length. And it is concluded that the two-finger gate HEMT with 250nm finger-gate length and 2.0µm cap-gate length has the best output characteristics, which output current is 0.159 A/µm at VGS=-1.5V. The results show that AlGaN/GaN HEMT with multi-finger gate have great potential for high power and high frequency applications electronic devices.
Different In Situ Immune Patterns Between Primary Tumor And Lymph Node In Non-Small Cell Lung Cancer: Potential Impact On Neoadjuvant Immunotherapy
Authors: Ye Zheng-Hao , Zhao Ze-Rui 
Published: August 2021

Abstract
Background Neoadjuvant immunotherapy is promising for locally-advanced non-small cell lung cancer (NSCLC). The in situ immune patterns, as predictor of PD-1/PD-L1 blockade outcomes, of the primary tumor (PT) and metastatic lymph nodes (mLNs) is unknown. Methods Multiplex immunofluorescence staining and multispectral imaging were used to evaluate the in situ immune patterns of T cells (CD3+) and cytotoxic T cells (CD8+) in terms of density, location (center of tumor [CT] and invasive margin [IM]), and the PD-L1 expression status of tumor cells and stromal T cells of paired PTs and mLNs in 38 stage-III NSCLCs.Results The densities of T cells and cytotoxic T cells were correlated between PTs and mLNs at both CT and IM. Higher densities of stromal T cells (S-CD3+) at CT and both S-CD3+ and cytotoxic T cells (S-CD8+) at IM were observed in mLNs compared to PTs, while in tumor compartment, there were no differences in the densities of T cells (T-CD3+) or cytotoxic T cells (T-CD8+). Only the density of stromal PD-L1-positive T cells (S-PD-L1+CD3+) at CT was correlated between PTs and mLNs, while the densities and frequencies of S-PD-L1+CD3+ at CT and IM of mLNs were higher than PTs. Combine positive score discordance of PD-L1 between PTs and mLNs was greater than tumor proportion score.Conclusions In situ immune patterns of T cells and cytotoxic T cells were different between PTs and mLNs in NSCLC. Higher densities of S-CD3+ and S-PD-L1+CD3+ in mLNs may result in better immune-mediated response to neoadjuvant immunotherapy.