bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Products and Their Promise Against COVID 19: Review
Authors: Temraz Abeer , Abo-Elghiet Fatma , Alharbi Hanan M. 
Published: September 2021

Background:
Since the beginning of medical history, plants have been exemplary
sources of a variety of pharmacological compounds that are still used in modern medication.

Respiratory infections are a serious and persistent global health problem, most acute and
chronic respiratory infections are caused by viruses, whose ability to mutate rapidly may result
in epidemics and pandemics, as seen recently with MERS-COV (2012) and SARS-COV-2
(2019), the latter causing coronavirus disease 2019 (COVID-19).

Methods:
This study aims to highlight the tremendous benefits of plants that have been widely
used as dietary supplements or traditional treatment for various respiratory infections, with a
focus on the most effective constituents and studies that revealed their activities against
COVID-19.

Results:
Several traditional plants and their phytoconstituents have shown activity against respiratory
viruses, including SARS-COV-2. The presented plants are Nigella sativa, Punica
granatum, Panax ginseng, Withania somnifera, Glycyrrhiza glabra, Curcuma longa, Zingiber
officinale, Camellia sinensis, Echinacea purpurea, Strobilanthes cusia, Stephania tetrandra,
and genus Sambucus.

Conclusion:
The data discussed in this review can encourage carrying out in-vivo studies that
may help in the discovery of herbal leads that can be feasibly used to alleviate, prevent or treat
COVID-19 infection.
Nanoencapsulation of Polyphenols as Drugs and Supplements for Enhancing
Therapeutic Profile - A Review
Authors: Shaikh Mohd. Farooq , Ansari Mohammed Tahir , Khatoon Saima , Kalam Nida , Hasnain M Saquib , Hafiz Aurangzeb Khurram 
Published: September 2021

:
Polyphenolic phytoconstituents have been widely in use worldwide since ages and are categorised as secondary metabolites of plants. The application of polyphenols such as quercetin, resveratrol. curcumin as nutritional supplement has been researched widely. The use of polyphenols, and specifically quercetin for improving the memory and mental endurance have shown significant effects among rats. Even though similar results has not been resonated among human but encouraging preclinical results have encouraged researchers to explore other polyphenols to study the effects as supplements among athletes. The phytopharmacological research has elucidated the use of natural polyphenols to prevent and treat various physiological and metabolic disorders owing to its free radical scavenging properties, anti-inflammatory, anti-cancer and immunomodulatory effects. In spite of the tremendous pharmacological profile, one of the most dominant problem regarding the use of polyphenolic compounds is their low bioavailability. Nanonization is considered as one of the most prominent approaches among many. This article aims to review and discuss the molecular mechanisms of recently developed nanocarrier-based drug delivery systems for polyphenols and its application as drugs and supplements. Nanoformulations of natural polyphenols are bioactive agents, such as quercetin, kaempferol, fisetin, rutin, hesperetin, and naringenin epigalloccatechin-3-gallate, genistein, ellagic acid, gallic acid, chlorogenic acid, ferulic acid, curcuminoids and stilbenes is expected to have better efficacy. These delivery systems are expected to provide higher penetrability of polyphenols at cellular levels and exhibit a controlled release of the drugs. It is widely accepted that natural polyphenols do demonstrate significant therapeutic effect. However, the hindrances in their absorption, specificity and bioavailability can be overcome using nanotechnology.
Metal Nanoparticles: Ligand-Free Approach Towards Coupling Reactions
Authors: Mengane Sharwari K. , Wu Ronghui , Ma Liyun , Panse Chhaya S. , Vajekar Shailesh N. , Patil Aniruddha B. 
Published: September 2021

:
Catalysis is a multidisciplinary field involving areas of organometallic chemistry, material
science and engineering. It finds use in the synthesis of various industrially applicable compounds,
such as fuels and fine chemicals. The activity and selectivity are fundamental issues to be
dealt with in catalysis, which are associated with the high surface area. Current research activities
primarily deal with homogeneous and heterogeneous catalysis. Although homogeneous and heterogeneous
catalysis have been well researched, they have certain drawbacks that need to be overthrown
for their wider applications. Therefore, it is imperative to find a catalytic protocol that would
lead to higher selectivity and exemplary product yield with quick and easy retrieval. Along with
being an alternative to conventional bulk materials, nanomaterials have further established their caliber
into various industrial and scientific applications. Nanocatalysis has emerged as an advanced
substitute for conventional homogeneous and heterogeneous catalysis. The nanomaterials are accountable
for intensifying the surface area of a catalyst, ultimately resulting in an increase in the
catalyst reactants' contacts. Furthermore, it enacts as a robust component providing high surface
area like a heterogeneous catalyst. Nanoparticles can be yielded out of a reaction medium due to
their insoluble behaviour, and thus, as catalysts, they can be retracted easily from the product.
Hence, it has been proven that nanocatalysts enact as both homogeneous and heterogeneous catalysts,
functioning as a bridge between the conventional catalytic systems. Considering these merits,
researchers have tried to intensively study the applications of nanocatalysts in numerous organic
reactions. This review article focuses on the catalytic applications of metal nanoparticles (MNPs),
such as Pd, Ag, Au, Cu, Pt, in ligand-free coupling reactions. Also, it covers the applications of bimetallic
and multimetallic nanoparticles in ligand-free coupling reactions.
Views on Using Social Robots in Professional Caregiving: Content Analysis of a Scenario Method Workshop
Authors: Busse Theresa Sophie , Kernebeck Sven , Nef Larissa , Rebacz Patrick , Kickbusch Ilona , Ehlers Jan Peter 
Published: September 2021

Background
Interest in digital technologies in the health care sector is growing and can be a way to reduce the burden on professional caregivers while helping people to become more independent. Social robots are regarded as a special form of technology that can be usefully applied in professional caregiving with the potential to focus on interpersonal contact. While implementation is progressing slowly, a debate on the concepts and applications of social robots in future care is necessary.

Objective
In addition to existing studies with a focus on societal attitudes toward social robots, there is a need to understand the views of professional caregivers and patients. This study used desired future scenarios to collate the perspectives of experts and analyze the significance for developing the place of social robots in care.

Methods
In February 2020, an expert workshop was held with 88 participants (health professionals and educators; [PhD] students of medicine, health care, professional care, and technology; patient advocates; software developers; government representatives; and research fellows) from Austria, Germany, and Switzerland. Using the scenario methodology, the possibilities of analog professional care (Analog Care), fully robotic professional care (Robotic Care), teams of robots and professional caregivers (Deep Care), and professional caregivers supported by robots (Smart Care) were discussed. The scenarios were used as a stimulus for the development of ideas about future professional caregiving. The discussion was evaluated using qualitative content analysis.

Results
The majority of the experts were in favor of care in which people are supported by technology (Deep Care) and developed similar scenarios with a focus on dignity-centeredness. The discussions then focused on the steps necessary for its implementation, highlighting a strong need for the development of eHealth competence in society, a change in the training of professional caregivers, and cross-sectoral concepts. The experts also saw user acceptance as crucial to the use of robotics. This involves the acceptance of both professional caregivers and care recipients.

Conclusions
The literature review and subsequent workshop revealed how decision-making about the value of social robots depends on personal characteristics related to experience and values. There is therefore a strong need to recognize individual perspectives of care before social robots become an integrated part of care in the future.
Soluble Klotho and Incident Hypertension
Authors: Drew David A. , Katz Ronit , Kritchevsky Stephen , Ix Joachim H. , Shlipak Michael G. , Newman Anne B. , Hoofnagle Andrew N. , Fried Linda F. , Sarnak Mark , Gutiérrez Orlando M. , Semba Richard D. , Neyra Javier A. 
Published: September 2021

Background and objectives
Hypertension is associated with significant morbidity and mortality despite effective antihypertensive therapies. Soluble klotho is a circulating protein that in preclinical studies is protective against the development of hypertension. There are limited studies of klotho and blood pressure in humans.

Design, setting, participants, & measurements
Within the Health, Aging, and Body Composition Study, a cohort of well-functioning older adults, soluble klotho was measured in serum. We evaluated the cross-sectional and longitudinal association between klotho and blood pressure, prevalent hypertension, incident hypertension, and BP trajectories. Analyses were adjusted for demographics, cardiovascular disease and kidney disease risk factors, and measures of mineral metabolism including calcium, phosphate, parathyroid hormone, 25(OH) vitamin D, and fibroblast growth factor 23.

Results
The median klotho concentration was 630 pg/ml (478–816, 25th to 75th percentile). Within the cohort, 2093 (76%) of 2774 participants had prevalent hypertension and 476 (70%) of the remaining 681 developed incident hypertension. There was no association between klotho and prevalent hypertension or baseline systolic BP, but higher klotho was associated with higher baseline diastolic BP (fully adjusted β=0.92 mmHg, 95% confidence interval, 0.24 to 1.60 mmHg, higher per two-fold higher klotho). Higher baseline serum klotho levels were significantly associated with a lower rate of incident hypertension (fully adjusted hazard ratio, 0.80; 95% confidence interval, 0.69 to 0.93 for every two-fold higher klotho). Higher klotho was also associated with lower subsequent systolic BP and diastolic BP (−0.16, 95% confidence interval, −0.31 to −0.01, mmHg lower systolic BP per year and −0.10, 95% confidence interval, −0.18 to −0.02, mmHg lower diastolic BP per year, for each two-fold higher klotho).

Conclusions
Higher klotho is associated with higher baseline diastolic but not systolic BP, a lower risk of incident hypertension, and lower BP trajectories during follow-up.
The Relation between Internal Forecasting Sophistication and Accounting Misreporting
Authors: Kroos Peter , Schabus Mario , Verbeeten Frank H. M. 
Published: September 2021

ABSTRACT
We examine the association between internal forecasting sophistication and end-of-the-year accounting misreporting. We draw on survey data from investment center managers of Dutch companies. Consistent with our hypothesis, results suggest that more sophisticated internal forecasting allows firms to reduce their costly accounting misreporting, as these firms make more accurate projections and create contingency plans such that they can revise operational plans in a more appropriate and timely manner. Cross-sectional analyses reveal that the benefits in terms of greater forecasting capabilities can vary across conditions. We find that investments in internal forecasting are less effective in reducing the demand for misreporting when environmental volatility is high, when capital market pressure to meet expectations is comparably high, and when within-firm information asymmetry is high. The paper especially speaks to the planning role of budgeting and forecasting, as opposed to the relatively more extensively studied evaluation and incentive role.
JEL Classifications: M12; M41.
СОЦИАЛЬНО-ПРОФЕССИОНАЛЬНОЕ САМОЧУВСТВИЕ СОТРУДНИКОВ ЮФУ: АНАЛИЗ ВОВЛЕЧЕННОСТИ И УДОВЛЕТВОРЕННОСТИ (2020-2021 гг.)
Authors: Михалкина Елена , Скачкова Людмила , Дюжиков Сергей , Шевченко Инна , Тарасенко Лариса , Астоянц Маргарита 
Published: September 2021

В данной работе представлены результаты двух этапов исследования соци-
ально-профессионального самочувствия сотрудников Южного федерального уни-
верситета, проведенных в 2019-2020 гг и 2020-2021гг. Результаты исследования
интерпретируются индикаторами уровня вовлеченности (дополнительных усилий
на рабочем месте в академической сфере, участие в реализации программ разви-
тия), индикаторами профессионального самочувствия (удовлетворенность рабо-
той в университете, удовлетворенность системой оплаты труда и социальными
льготами, удовлетворенность рабочим графиком и условиями труда, удовлетво-
ренность программами обучения сотрудников), индикаторами социального само-
чувствия (удовлетворенность отношениями в коллективе, оценка выполнения
условий социально-трудовых отношений, оценка реализации возможностей ком-
муникации, оценка социального благополучия), а также индикаторами психоло-
гического самочувствия (удовлетворенность жизнью в целом и уровень счастья
академических работников, оценка стресса, оценка баланса между работой и лич-
ной жизнью, оценка психологического комфорта). Данные исследовательские ре-
зультаты будут интересны с позиции принятия управленческих решений и разра-
ботки комплексной системы мотивации сотрудников университета
Benefits and drivers of inclusive human capital development
Authors: Kosorukova Irina Vyacheslavovna , Kukharenko Olesya Gennadievna , Orekhov Viktor Dmitrievich , Piel Helena , Karanashev Anzor Khasanbievich 
Published: September 2021

The paper aims to analyze the benefits and drivers of economic transformation through the development of human capital using inclusive principles. The study is a continuation of a series of works on modeling the system of labor activity using the factors of knowledge, education, and human capital. The research methodology includes both quantitative studies of the impact of knowledge and education on economic dynamics, and qualitative studies of the benefits and forces that promote and counteract fruitful inclusive changes. According to the analysis of the field of forces, the factors that counteract inclusive socio-economic changes (educational differentiation, the desire to have wealth and power) have, in general, high strength. The forces that contribute to change are relatively less powerful, but more numerous, which allows counting on the successful implementation of positive inclusive changes.
Assessment of iris vasculature abnormalities in dogs with diabetes mellitus
Authors: Pirie Christopher G. , Shelnutt Leslie M. , Langlois Daniel K. 
Published: September 2021

Abstract

OBJECTIVE
To identify and characterize abnormalities of iris vasculature in dogs with diabetes mellitus, compared to clinically normal, age-matched control dogs, by means of anterior segment angiography.

ANIMALS
10 dogs with naturally occurring diabetes mellitus and 10 age-matched control dogs with no ocular or systemic disease.

PROCEDURES
The day before iris vasculature abnormality (IVA) assessment, all dogs underwent complete physical and ophthalmic examinations and baseline clinicopathologic analyses. For diabetic dogs, serum fructosamine concentration and a 12-hour blood glucose concentration curve were generated. The next day, all dogs were sedated and anterior segment angiography (following IV injection of indocyanine green [1 mg/kg] and subsequently sodium fluorescein [20 mg/kg]) was performed with a full-spectrum camera and camera adapter system. Group findings were compared, and multiple linear regression analysis was performed to identify potential factor associations with IVAs.

RESULTS
During anterior segment angiography, the arterial, capillary, and venous phases were identified in all dogs. Times to onset of all phases in diabetic dogs were significantly less than those in control dogs. Vascular disruptions within the peripupillary region (evident following sodium fluorescein administration) were common in diabetic dogs. Severity of dye leakage into the iris stroma and aqueous humor was significantly greater in diabetic dogs than in control dogs. Duration of disease, mean blood glucose concentration, and serum fructosamine concentration were significantly associated with IVAs.

CONCLUSIONS AND CLINICAL RELEVANCE
In diabetic dogs, anterior segment angiography revealed IVAs that were not evident in control dogs. The severity of those changes appeared to be associated with disease duration and blood glucose regulation.
Plasma concentrations of tramadol after transdermal application of a single metered dose of a compounded tramadol gel to cats
Authors: Aldrich Lauren A. , Roush James K. , KuKanich Butch 
Published: September 2021

Abstract

OBJECTIVE
To determine plasma tramadol concentrations in cats following a single dose of oral and transdermal formulations and the pharmacokinetics for and the concentration of tramadol in the transdermal formulation.

ANIMALS
8 healthy client-owned domestic shorthair cats.

PROCEDURES
1 cat was orally administered 1 dose of tramadol (2 mg/kg), and 7 cats received 1 dose of a proprietary compounded tramadol gel product (median actual dose, 2.8 mg/kg) applied to their inner pinnae. Plasma tramadol concentrations were measured with high-performance liquid chromatography–mass spectrometry at fixed times over 24 hours.

RESULTS
Plasma tramadol concentrations were undetectable or much lower (range, < 1 to 4.3 ng/mL) following application of the transdermal formulation, compared with those following oral administration (maximum plasma tramadol concentration, 261.3 ng/mL [at 4 hours]). Tramadol pharmacokinetics for the transdermal formulation could not be determined. Tramadol concentrations of the transdermal gel product exceeded the estimated label dose in all analyzed gel samples, with concentrations greater than the 90% to 110% United States Pharmacopeia standard for compounded drugs.

CONCLUSIONS AND CLINICAL RELEVANCE
Application of 1 dose of the proprietary transdermal formulation did not yield clinically relevant plasma tramadol concentrations in cats. Although this proprietary formulation is currently available to prescribing veterinarians, it should be used with caution.
Pendampingan Lansia dalam Pelayanan Keperawatan Mandiri Dengan Masalah Nyeri Kronik
Authors: Hidayat Syaifurrahman , Hannan Mujib 
Published: September 2021

The decreasing of biological function in the aging process affecting a damage in organ tissue in the elderly, so they are easy to be susceptible of diseases including chronic pain. Pain management in the elderly with osteoarthritis in the community in large mount use pain relievers, and rarely use non-pharmacological therapy, even though the use of non-pharmacological pain management has a smaller risk of drug side effects. The solution needed to be done is Assistance to elderly in Independent Nursing Services with Chronic Pain Problems.
The implementation method is providing health education to elderly families, mentoring chronic pain management independently, assisting in developing an integrated healthcare center program for the elderly on chronic pain management and conducting training for elderly health cadres.
The results of the implementation of mentoring for elderly were carried out in four activities including health counseling for the elderly and family, assistancing in managing chronic pain independently, optimizing the elderly integrated healthcare center program on pain management and training for elderly health cadres.
Assistancing for the elderly in independent nursing services as part of human resource development efforts in improving the handling of problems that occur in the elderly, one of which is chronic pain in the elderly, namely with independent nursing services that can be done at home, so that it becomes part of promotive and preventive efforts
PELAKSANAAN FUNGSI SOSIAL HAK ATAS TANAH DI PT. GARAM KABUPATEN SUMENEP
Authors: Sutrisni Sutrisni , Sugiarti Yayuk 
Published: September 2021

Berdasarkan Undang-Undang nomor 5 tahun 1960 tentang Peraturan Dasar Pokok-pokok Agraria, pada pasal 19 dinyatakan bahwa untuk menciptakan kepastian hukum Pertanahan, Pemerintah menyelenggarakan pendaftaran tanah. Atas tanah yang telah didaftarkan selanjutnya diberikan tanda bukti hak atas tanah, yang merupakan alat bukti yang kuat mengenai kepemilikan tanah. Dalam pendaftaran tanah, girik yaitu tanda bukti pembayaran pajakatas tanah dapat disertakan untuk proses administrasi. Girik, dengan demikian bukan merupakan tanda bukti kepemilikan hak atas tanah, namun semata-mata hanyalah merupakan bukti pembayaran pajak-pajak atas tanah. Dengan demikian, apabila di atas bidang tanah yang sama, terdapatklaim dari pemegang girik dengan klaim dari pemegang surat tanda bukti hak atas tanah (sertipikat), maka pemegang sertipikat atas tanah akan memilikiklaim hak kebendaan yang lebih kuat.
TINJAUAN YURIDIS TENTANG HAK MILIK YANG DIGUNAKAN OLEH NEGARA UNTUK KEPENTINGAN UMUM
Authors: Sjaifurrachman Sjaifurrachman , Fithry Abshoril 
Published: September 2021

Penelitian ini dilakukan untuk mendapatkan gambaran tentang Mekanisme dalam Pelepasan Tanah Untuk Kepentingan Umum. Mekanisme yang dituangkan dalam Undang-Undang No.2 Tahun 2012 tentang pengadaan tanah bagi pembangunan untuk kepentingan umum berbeda dengan mekanisme yang di atur dalam KUH Perdata, di mana dalam KUH Perdata mekanisme dapat dilakukan jika sebelumnya terdapat hubungan hukum antara para pihak. Sedangkan mekanisme yang diterapkan disaat kesepakatan antara para pihak tidak tercapai, tidak ada hubungan hukum sama sekali diantara para pihak tersebut. Dari uraian latar belakang diatas maka Permasalahan yang diangkat dalam penelitian ini Bagaimana prosedur pelepasan hak milik atas tanah yang dilakukan oleh Pemerintah untuk kepentingan umum dan Bagaimana penyelesaian hukum yang dapat dilakukan oleh Pemerintah jika terjadi sengketa dalam pelepasan hak milik atas tanah untuk kepentingan umum. Tujuan yang hendak dicapai untuk mengetahui dan menganalisa prosedur pelepasan hak milik atas tanah yang dilakukan oleh Pemerintah untuk kepentingan umum dan untuk mengetahui dan menganalisa upaya penyelesaian hukum yang dapat dilakukan oleh Pemerintah jika terjadi sengketa dalam pelepasan hak milik atas tanah untuk kepentingan umum.
KEDUDUKAN BENDA JAMINAN YANG DIBEBANI HAK TANGGUNGAN APABILA TERJADI EKSEKUSI DALAM HAL DEBITUR WANPRESTASI
Authors: Sjaifurrachman Sjaifurrachman , Fithry Abshoril 
Published: September 2021

Orang melakukan perikatan dengan yang lain guna memenuhi kebutuhan hidupnya dengan cara barter (penukaran barang dengan barang), lalu berubah menjadi penukaran barang dengan uang barang dan kemudian berganti menjadi barang dengan uang.
Wanprestasi adalah ketiadaan suatu prestasi didalam hukum perjanjian, berarti suatu hal yang harus dilaksanakan sebagai isi dari suatu perjanjian. Barangkali daslam bahasa Indonesia dapat dipakai istilah “pelaksanaan janji untuk prestasi dan ketiadaan pelaksanaannya janji untuk wanprestasi.