bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the Impacts of Climate Changes on the Distribution of Aloe vera Species in Ethiopia
Authors: Hussein Abdulbasit , Workeneh Sintayehu 
Published: September 2021

Abstract
Climate change is considered to be one of the most significant challenges to global biodiversity in the 21st century and remains the greatest challenge to biodiversity conservation in the future. Consequently, understanding the effects of climate change on biodiversity can enhance conservation efforts. The use of niche modeling to predict changes in the suitable distribution of species under climate change scenarios is becoming a hot topic of biological conservation. Thus, this study investigated the impacts of climate changes on the distribution of Aloe vera species of concern in Ethiopia. Occurrence data were obtained from the Global Biodiversity Information Facility (GBIF; www.gbif.org/ (1 March 2021)) and specimen collection of the Ethiopian biodiversity institute. Maxent models were used to predict the potential suitable distribution of the Aloe vera species under different climate change scenarios in the present day (the 2020s) 2050s, and 2070s in Ethiopia. In the modeling process, the Akaike information criterion (AIC) was used to choose the best combination of feature type and regularization multiplier. Variables relating to temperature and precipitation were more important variables in predicting Aloe vera species distribution in the optimal model. The predicted suitable distribution areas of Aloe vera were different for the different periods under different climate change scenarios. The suitable distribution area is predicted to become more fragmented in the future. Results reveal the climate conditions suffer the distribution of Aloe vera in Ethiopia and the likely changes to its distribution pattern in the future and Aloe vera are under great threat of extinction from climate changes, providing a scientific basis for the sustainable management, protection, and restoration of the suitable habitat of this economically important vegetation in the context of changing climate condition. Therefore, increased forest protection to prevent further forest cover losses will be key for the Aloe vera species conservation.
ALK Rearrangement-Associated Renal Cell Carcinoma Morphologically Mimicking Mucinous Tubular And Spindle Cell Carcinoma: A Case Report
Authors: Kai Keita , Tobu Shohei , Kido Shinichi , Mikami Shuji , Takeuchi Kengo , Dobashi Akito , Togashi Yuki , Noguchi Mitsuru , Aishima Shinichi 
Published: September 2021

Abstract
Background: Anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC) is a very rare tumor and no single case report of ALK-RCC that mimics mucinous tubular and spindle cell carcinoma (MTSCC) has been reported.Case presentation: A 42-year-old Japanese woman was admitted to our hospital for the treatment of a left renal tumor measuring approximately 5 × 4 cm in diameter. She underwent a laparoscopic left nephrectomy. Histologically, the tumor formed tubular or focally papillary structures with a small amount of spindle-shaped tumor cells against the background of prominent extracellular mucin. Although the tumor cells were negative for immunohistochemistry (IHC) of alpha-methylacyl-CoA racemase (AMACR) and lymph node metastasis was presented (these are atypical findings for MTSCC), we initially diagnosed the tumor as MTSCC based on its morphological characteristics with mucin deposition. However, an additional IHC analysis revealed that the tumor cells were diffusely positive for ALK-IHC. In addition, TPM3 exon 8 – ALK exon 20 fusion gene was detected by RNA sequencing. The tumor was thus correctly diagnosed as ALK rearrangement-associated renal cell carcinoma (ALK-RCC). Conclusions: Since the use of molecular targeted therapy with an ALK inhibitor for ALK-RCC is promising, the correct pathological diagnosis of ALK-RCC is quite important. We strongly recommend that ALK-IHC be routinely performed for renal tumors with negative AMACR staining that mimic MTSCC.
Seed storage protein variation in Indian barley using 2-D diagonal gel electrophoresis approach
Authors: Sharma Jitendra Kumar , Sihmar Monika , Santal Anita Rani , Singh Nater Pal 
Published: September 2021

Abstract
Barley is the fourth most important cereal, which is used as feed and fodder. It is also used as raw material in the brewing industry and is rich in soluble dietary fiber. Thus, it has economic as well as health benefits. The present study studied seed storage protein characterization of malt, feed, two row, six row, salinity tolerant and susceptible Indian barley genotypes. The polymorphic bands in feed and malt barley were 59% and 54%; in two and six-row barley 35% and 59%; and in salt-tolerant and susceptible barley 38% and 59%. The salt-tolerant lines DL 88 and NB 1were exhibited five interlinked polypeptides, while NDB 1173, NB 3, and RD 2552 exhibited four, two, and one interlinked disulfide linkage, respectively. Whereas, in the case of salt susceptible lines Alfa 93, NB 2, K 508, BH 393 and K 551 a total of six each in Alfa 93 and K 551 barley lines, while in K 508 BH 393 barley lines, two disulfide-linked polypeptides were found. The current study portrayed a simple and economical procedure to characterize the seed protein by gel electrophoresis. Characterization of seed storage proteins by banding pattern analysis using one dimensional SDS-PAGE is the simple molecular technique to evaluate the barley lines with particular traits such as salinity tolerance ability, malt or feed quality, and others. The unique protein bands can also be used as a marker to identify the lines.
Impact of Oral Health-Related Quality of Life among Addicts' People in Ahvaz City; Iran
Authors: Saki Fatemh , Mohamadian Hashem , GhorbanyJavadpour Fataneh , Cheraghi Maria 
Published: September 2021

Abstract
Backgrounds: Quality of life related to oral health impact profile-14 (OHIP-14) is one of the important dimensions of quality of life. Since using narcotics or stimulants increases the incidence of periodontal diseases, we aimed to determine impact of Oral health-related quality of life in narcotic or stimulant addicts who referred to maintenance methadone therapy (MMT) centers in Ahvaz City, Iran.Methods: It was descriptive-analytical cross-sectional study which has conducted on 187 narcotic and stimulant addicts who referred to MMT centers in Ahvaz city; 2020. The data collection tools included the demographic variables and the standard OHIP-14 questionnaires. Descriptive statistics, independent t-test, one-way analysis of variance, and LMS test were run at the significance level of less than 0.05. Results: The mean and standard deviation of the participants' age was 36.03 ± 8.98 years. The quality-of-life scores related to oral health were 34.89 ± 6.50 totally as well as 37.37 and 33.96 in narcotic and stimulant addicts, respectively. The total quality of life related to OHIP-14 did not have a significant relationship with variables of age, life companions, level of education, number of children, economic status, employment status, insurance status, underlying disease, toothbrush use status, last dentist visit, and number of missing teeth (P> 0.05). However, a significant difference was found between the quality of life related to oral health based on the type of substance used (narcotic or stimulant), so that the mean quality of life related to oral health was higher in narcotic addicts than stimulant users (P <0.05). Conclusion: The quality of life related to OHIP-14 was more unfavorable in stimulant users than narcotic users. So, policy makers and authorities are required to focus their interventions and research programs to improve health-related quality of life in addicts, especially stimulant users.
Psychometric Properties of Nepali Translated Version of Preschool Anxiety Scale (Parent) Among Preschool Children in Nepal
Authors: Maharjan Sabina , Rana Mita , Neupane Bidusha , Rijal Sujan , Shakya Suraj , Pradhan Pramesh Man , Ojha Saroj Prasad , Gautam Kamal 
Published: September 2021

Abstract
Background

The Preschool Anxiety Scale (PAS) is a 28- item measure designed to assess anxiety symptoms in pre-schoolers aged 3 to 6 years. The aim of this study is to assess the psychometric properties of the Nepali translated version of the Preschool Anxiety Scale -Parent version, together with evidence on the reliability and cross-informant agreement among parents.
Methods

A descriptive cross-sectional design was used to collect data from 680 mothers among seven conveniently selected private schools in Kathmandu.
Results

Age groups and gender differences across PAS scales were found statistically significant in mother’s reports. Exploratory factor analyses results suggest that the items of the PAS- Nepalese version do not reflect the five categories in anxiety in a clear way. This is particularly in separation anxiety, social phobia, and obsessive-compulsion. In confirmatory factor analysis, 28 items showed a poor fit of the five-factor original model for the data. However, removing three items (25 item version) through the five-factor model indicated a better fit. Internal consistency measured by Cronbach’s alpha for the PAS-Parent version scale was of good range (0.87). Cronbach’s alpha of the subscales: generalized anxiety (0.63), social phobia (0.67), physical injury fears (0.75), and Separation anxiety (0.63) were in fair range; while it was in poor range for the Obsessive-Compulsive subscale (0.567). Cross informant agreement on the ratings of anxiety symptoms of children by the fathers and mothers was low, as reflected by a weak positive correlation.
Conclusion

Nepalese version of the PAS demonstrated fair psychometric properties, supporting its utility in screening and assessing a broad range of anxiety symptoms in Nepalese pre-schoolers.
Effectiveness of Community-based Substance Use Prevention Program Among Adolescents - Using Social Cognitive Theory
Authors: Fathian-Dastgerdi Zohreh , Eslami Ahmad-Ali , Ghofranipour Fazlolah , Mostafavi Firoozeh 
Published: September 2021

Abstract
BackgroundThis study aims to assess a tailored community-based intervention protocol for preventing substance use in Iranian adolescents based on social cognitive theory. MethodsAn ecological approach, Mobilizing for Action through Planning and Partnership(MAPP), was used to develop an intervention for preventing substance use among 180 adolescences (14-18 years old) participating in the study in Iran, through six main steps. Outcomes were analyzed 6, 18, and 24 months later by the SPSS.23. RM-ANOVA, ANCOVA, and Pearson correlation tests were used for data analysis.ResultsAlmost more than 40% of the adolescents from Qhahjavarestan county participated in this study in 4 stages measurement. Substance use behavior explainers, including positive outcome expectancies (p<0.001, F=25), negative outcomes expectancies (p<0.001, F=31.2), and self-efficacy (p<0.001, F=12.3), were significantly promoted in the intervention group at three stages (6, 18, and 24 months after intervention). The program demonstrated insignificant reductions in cigarette, alcohol, and drug use at the initial users, but the incidence of new cases of cigarette using (p<0.001, F=9.93) and alcohol drinking (p<0.07, F=2.9) in the intervention group was reduced at 6 and 18 months after the intervention.Conclusion﻿Our results support the effectiveness of a community-based educational program based on social cognitive theory to reduce the incidence of new cases of drug users among adolescents. More effective educational interventions with a greater focus on self-efficacy and social support may be warranted.
Adenosine inhibits TNFα-induced MMP-3 Production in MH7A RA Synoviocytes via A2A Receptor Signaling
Authors: Konishi Hiroe , Kanou Shun-En , Yukimatsu Rika , Inui Mizuki , Sato Motoya , Yamamoto Naruto , Nakano Masayoshi , Koshiba Masahiro 
Published: September 2021

Abstract
BackgroundAdenosine is the effector molecule mediating the antirheumatic effects of methotrexate, but the contributions of synoviocyte adenosine receptors (AdoRs) are unknown. Matrix metalloproteinase 3 (MMP-3) is released by fibroblast-like synoviocytes in response to inflammatory signaling, and serum MMP-3 is elevated during active rheumatoid arthritis. To elucidate the therapeutic mechanisms of methotrexate, we investigated the effects of A2A AdoR activation and inhibition on tumor necrosis factor-alpha (TNFa)-induced MMP-3 release by MH7A human rheumatoid synovial cells.MethodsCultured MH7A cells were treated with 25 pg/ml TNFa or vehicle for 24 h in the presence or absence of the selective A2A AdoR agonist HENECA (10, 50, or 100 nM), and MMP-3 release was measured in the culture supernatant. In other experiments, cells were treated with TNFa plus the cAMP analog dbcAMP or pretreated with the A2A AdoR antagonist ZM241385 prior to TNFa with or without HENECA. Activation of the p38 MAPK signaling pathway was evaluated by western blotting of phosphorylated signaling proteins. Treatment group means were compared by independent samples t-tests.ResultsMH7A cells constitutively expressed membrane-associated A2A AdoRs, and HENECA enhanced intracellular cAMP, indicating that these receptors are functionally coupled to adenylyl cyclase. Stimulation with TNFa markedly enhanced release of MMP-3 from MH7A cells, whereas HENECA partially and dose-dependently inhibited TNFa-evoked MMP-3 release. Similarly, dbcAMP partially inhibited TNFa-induced MMP-3 release. Pretreatment with ZM241385 reversed the inhibitory effects of HENECA. Further, TNFa induced p38 MAPK and ATF-2 phosphorylation, whereas HENECA suppressed p38 MAPK and ATF-2 phosphorylation.ConclusionsAdenosine signaling via A2A AdoRs, adenylyl cyclase, and cAMP reduces (although does not completely block) TNFa-induced MMP-3 production, by interfering with p38 MAPK/ATF-2 activity. Activation of A2A AdoR pathway and suppression of MMP-3 release may explain the antirheumatic effects of methotrexate.
Assessing the need for resuscitative endovascular balloon occlusion of the aorta (REBOA) for management of non-compressible hemorrhage at a Canadian urban trauma centre: a retrospective chart review.
Authors: Purssell Elizabeth , Patrick Sean , Haegert Joseph , Ivkov Vesna , Taylor John 
Published: September 2021

Abstract
Background

Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a less invasive alternative to resuscitative thoracotomy (RT) for life threatening, infra-diaphragmatic, non-compressible hemorrhage from trauma. Existing evidence surrounding the efficacy of REBOA is conflicting; nevertheless, expert consensus suggests that REBOA should be considered in select trauma patients. There has been a paucity of studies that evaluate the potential utility of REBOA in the Canadian setting. The study objective was to evaluate the percentage of trauma patients presenting to a Level 1 Canadian trauma centre that would have met criteria for REBOA.
Methods

We conducted a retrospective chart review of patients recorded in the British Columbia Trauma Registry who warranted a trauma team activation (TTA) at our institution. We identified REBOA candidates using pre-defined criteria based on published guidelines. Each TTA case was screened by a reviewer, and then each Potential Candidate was reviewed by a panel of trauma physicians for determination of final candidacy.
Results

Fourteen patients were classified as Likely REBOA Candidates (2.2% of TTAs, median age 46.1 years, 64.3% female). These patients had a median Injury Severity Score of 31.5 (IQR 26.8). The main sources of hemorrhage in these patients were from abdominal injuries (71.4%) and pelvic fractures (42.9%).
Conclusion

The percentage of patients who met criteria for REBOA is similar to that of RTs performed at our Canadian institution. While REBOA would be performed infrequently, it is a less-invasive alternative to RT, which could be a potentially life-saving procedure in a small group of the most severely injured trauma patients.
Intimate Partner Violence (IPV) Against Pregnant Women And Unfavourable Birth Upshot in Ekiti State, Nigeria
Authors: AGBANA Richard Dele , Owoseni Joseph Sina , Akintimoye Johnson O 
Published: September 2021

Abstract
Background

Intimate partner violence is a typical phenomenon in Nigerian families. About 86% of women accepted that a man is legitimized in beating or being violent again his wife. Around 35–65% of families were affected by their intimates. Women always suffer sexual, physical, economic and emotional, social violence from their intimate partners. It always remains either for family secrecy, cultural norms, or, because of dread, stigma and the community's hesitance on the domestic affair and social shame. The objective of this research is to examine the relationship and association between intimate partner violence against pregnant women and unfavourable birth results.
Methods

A clinical-based and unparalleled case-control study was conducted in four government hospitals in Ekiti State, Nigeria. An aggregate of 644 (284 cases and 360 controls) research participants were taken. In the main, systematic sampling was utilized to choose the cases and controls. Ethical clearance was acquired all through the research period.
Results

Consequently, out of the total 644 mothers interviewed women, 429 (66.6%) had encountered intimate partner violence during the pregnancy period. Multivariate logistic regression analysis indicated that pregnant women exposed to intimate partner violence were multiple times bound to encounter low birth weight (AOR = 2.9; CI 95% (1.398, 6.587)) and preterm birth (AOR = 2.7; CI 95% (3.198–4.017)). It was discovered that women, who were exposed to physical violence during pregnancy were multiple times bound to experience low birth weight (AOR = 4.563; CI 95% (2.685, 8.684)) and preterm birth (AOR = 6.1; CI 95%: (4.01, 7.154)). (AOR = 4.563; 95% CI (2.685, 8.684
Conclusion

It was discovered that the danger of low birth weight and preterm birth would be on the increase when there is an exposure of pregnant women to various forms of intimate partner violence and certain physical violence in pregnancy. Subsequently, various efforts must be put in place in addressing maternal and infant healthcare needs to incorporate issues of violence against pregnant women in Ekiti State and Nigeria at large.
Reactions of Some Varieties of Pearlmillet, Pennisetum glaucum (Linn.) R. Br. emend Stuntz. to Rice Moth, Corcyra cephalonica Staint
Authors: Sharma Anita , Kumawat K.C. , Khinchi S.K. 
Published: September 2021

Abstract
Ten varieties of pearlmillet (RHB-173, RHB-177, MPMH-17, HHB-67, Pro Agro-9450, Pro Agro-9001, Pioneer 86 m 86, Pioneer 86 m 84, Pioneer 86 m 38 and Raj-171.) were evaluated for reaction to Corcyra cephalonica Staint. in the laboratory conditions. The adult emergence (F1), weight losses and susceptibility index in these varieties were ranged from 9.33-32.00, 10.44-31.69% and 2.77-6.82, respectively, the minimum in Pioneer 86 m 86 and maximum in Raj-171; other varieties were in the middle order. The seed damage recorded in different varieties ranged from 23.67-75.84%, the minimum in Pioneer 86 m 86 (23.67%), Pro Agro-9450 (25.55%) and Pro Agro-9001 (28.33%), these treatments were found at par each other. The Raj-171 was found to be badly infested (75.84% grain damage) which differed significantly over other varieties. The developmental period of the pest varied from 50.88-80.61 days in different varieties, minimum being in Raj-171 and maximum in Pioneer 86 m 86.
Platelet is the Early Predictor of Bronchopulmonary Dysplasiaa in Very Premature Infants: An Observational Cohort Study
Authors: Wang Xiaoling , Ma Yan , Wang Shenghui , Dong Wenbin , Lei Xiaoping 
Published: September 2021

Abstract
Background: A previous study showed that the lungs are involved in the biogenesis of platelets (PLTs). Thus, the present study aimed to investigate the association between bronchopulmonary dysplasia (BPD), a chronic lung disease, and PLT parameters in very premature infants.Methods: The study subjects were premature infants with a gestational age of < 30 weeks and birth weight of < 1500 g in a preterm birth cohort study recruited between January 1, 2015, and August 31, 2019. BPD was defined as the need for oxygen supplementation more than 28 days after birth. The PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) level were compared between BPD and non-BPD infants. A generalized estimating equation model was used to adjust for confounding factors. A forward stepwise logistic regression model was used to calculate the adjusted odds ratio (OR) for thrombocytopenia in the BPD group.Results: The final study subjects were 134 very premature infants, namely, 64 infants with BPD and 70 infants without BPD. The BPD infants had lower PLT counts (F=25.39, P=0.00) and PCT levels (F=41.16, P=0.00) than the non-BPD infants. However, the MPV (F=37.65, P=0.00) and PDW (F=28.43, P=0.00) were higher in the BPD group. After adjusting for potential confounding factors, the BPD infants had a higher risk of thrombocytopenia than the non-BPD infants (adjusted OR 3.18, 95% CI 1.21, 8.35), and the risk of BPD was increased in very premature infants with a PLT count ≤ 177*109/l (OR 4.74, 95% CI 1.93–11.62) at the end of the second week.Conclusions: Abnormal PLT parameters were observed in BPD infants, and a PLT count ≤ 177*109/l was an early predictor for BPD in very premature infants.
A Pure NanoICG-Based Homogeneous Lipiodol Formulation: Toward Precise Surgical Navigation of Hepatocellular Carcinoma After Long-Term Transcatheter Arterial Embolization
Authors: Zhang Yang , Cheng Hongwei , Chen Hu , Xu Peiyao , Ren En , Jiang Yonghe , Li Dengfeng , Gao Xing , Zheng Yating , He Pan , Lin Huirong , Chen Biaoqi , Lin Gan , Chen Aizheng , Chu Chengchao , Mao Jingsong , Liu Gang 
Published: September 2021

Abstract
Purpose To surmount the critical issues of clinical hepatectomy and achieve a precise surgical navigation of hepatocellular carcinoma after long-term transcatheter arterial embolization (TAE).Methods A facile and green pure-nanomedicine formulation technology was developed to construct carrier-free indocyanine green nanoparticles (nanoICG). The nanoICG was dispersed into lipiodol via a super-stable homogeneous lipiodol formulation technology (SHIFT nanoICG) for TAE combined with near-infrared fluorescence-guided precise hepatectomy.Results We demonstrate that SHIFT nanoICG integrates excellent anti-photobleaching capacity, great optical imaging properties, and specific tumoral deposition to recognize tumor regions, featuring sufficient physical stability for fluorescence-guided precise hepatectomy. Importantly, SHIFT nanoICG is capable of visualizing all lesions in rabbit-bearing VX2 orthotopic hepatocellular carcinoma models, even the tiny focus to 0.6 × 0.4 mm.Conclusion Our findings indicate that SHIFT nanoICG provides a promising avenue to address the clinical issue of hepatectomy and has excellent potential for a translational pipeline.