bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring Health-Related Quality of Life in Vietnamese Patients After Kidney Transplantation
Authors: Vu Le Nguyen , Nghia Nguyen Quang , Tuan Tran Minh , Phuong Tran Ha , Vo Hoang-Long , Viet Khai Ninh , Giang Tran Binh 
Published: August 2021

Objectives: To consider that the health-related quality of life (HRQOL) has become an inherent part of the patient outcomes in the care and treatment after kidney transplantation (KT). This study aimed to measure HRQOL among a representative sample size of patients after KT by using both the Short Form 36 (SF-36) and the Kidney Disease Quality of Life 36 (KDQOL-36).Methods and Results: Data of this cross-sectional design were collected in the Organ Transplant Center, Viet Duc University Hospital (Hanoi, Vietnam) from January 2020 to March 2020 and included the patients aged 18 years or over after KT at 6 months, 1 year, and 3 years postoperatively. HRQOL was evaluated through face-to-face interviews by means of the SF-36 and KDQOL-36 measurement tools. According to the SF-36, the overall mean score of HRQOL was 69.13 ± 15.55 and the two domains were the highest scores of “Mental Health” (81.23 ± 14.28) and “General Health” (80.06 ± 14.81). When measuring with the KDQOL-36, the overall mean score was 68.67 ± 13.75 and was the highest in the domain “Symptoms and Problems of Kidney Disease” (87.06 ± 16.00). Both instruments had good reliability for those after KT. The reliability of the SF-36 was high with Cronbach's coefficients α = 0.90. There were positive relationships between the dimensions measured by the KDQOL-36 and SF-36 (correlation coefficient: 0.03–0.69). Similarly, the domains of the SF-36 also had positive correlations with the KDQOL-36 (correlation coefficient: 0.18–0.51). The correlation coefficient between overall HRQOL scores of the SF-36 and KDQOL-36 was 0.62, indicating a strong correlation between the SF-36 and KDQOL-36.Conclusions: There were slight fluctuations in the HRQOL score in domains in the 3-year follow-up stages, suggesting not having clear change. The mean SF-36 score was consistent with the mean KDQOL-36 score. High reliability and strong correlation were found between two instruments of the SF-36 and KDQOL-36. This study provides the reliability and constructs validity in the combination of two sets of the SF-36 and KDQOL-36 scales for the assessment of HRQOL among post-KT patients, thereby assisting physicians and health professionals in the clinical decision-making, assessment of therapeutic efficacy, and understanding of treatment risk.
The Effectiveness of Self-Instructional Video vs. Classroom Teaching Method on Focused Assessment With Sonography in Trauma Among House Officers in University Hospital
Authors: Isa Mohd Hisham , Lim Kristina , Jaafar Mohd Johar , Mohd Saiboon Ismail 
Published: August 2021

Background: The aim of this study was to compare the effectiveness of self-instructional-video (SIV) and classroom training method (CTM) in learning Focus-Assessment with Sonography-in-Trauma (FAST) among house officers (HO).Method: A randomized controlled study involving house officers working in the university hospital in Malaysia was conducted where participants were randomized into SIV group (intervention) and CTM group (control). Each group had to undergo a 4 h hands-on training. The intervention group has undergone self-training using the video material without any facilitation while the control group received lecture and hands-on training with facilitators. Participants' performance was assessed using a validated Objective Structured Clinical Examination checklist for landmark identification and interpretation of images generated. Learning preference and confidence level were also assessed.Result: A total of 33 HO were enrolled in this study. Marks obtained in image acquisition by the intervention and control were 25.3 (SD = 5.3) and 25.6 (SD = 2.3) p &gt; 0.05, respectively. While in image interpretation, the mean score for the intervention and control group was 10.3 (SD 1.7) and 9.8 (SD = 1.7) p &gt; 0.05, respectively. Overall performance assessment, showed the intervention group obtained 35.6 (SD = 5.9) compared to control 35.3 (SD = 3.4), p &gt; 0.05. Based on pre-specified determinant these scores difference falls within the 10% of non-inferiority margin. The absolute difference between both groups was 0.3 (CI = −3.75 to 3.21, p = 0.871), which proves non-inferiority but not superiority. In terms of learning preference and confidence to perform FAST, most of the participants preferred the control group approach.Conclusion: The SIV method is as effective as the CTM for learning FAST among the house officers and served as an alternative to classroom teaching. However, this technique needs improvement in promoting their confidence and preference. Perhaps incorporating a feedback session after going through the SIV would improve the confidence.
Effectiveness of a Video-Based Intervention on Reducing Perceptions of Fear, Loneliness, and Public Stigma Related to COVID-19: A Randomized Controlled Trial
Authors: Valeri Linda , Amsalem Doron , Jankowski Samantha , Susser Ezra , Dixon Lisa 
Published: August 2021

Objectives:During the first peak of the COVID-19 outbreak in the United States, we investigated the impact of digital interventions to reduce COVID-19 related fear, loneliness, and public stigma.Methods:We recruited and randomly assigned 988 United States residents to: 1) no intervention 2) informational sheet to learn about COVID-19, 3) (2) AND video encouraging digital social activity, 4) (2) AND video sensitizing to COVID-19 related stigma (registered in Clinicaltrials.gov). Surveys were conducted between April 2-16, 2020. We employed generalized linear mixed models to investigate intervention effects.Results:10% of the participants reported not being afraid of people COVID-19+ and 32% reported not feeling lonely. Stigma and fear items reflected acute worries about the outbreak. Relative to the informational sheet only group, video groups led to greater reduction in perceptions of fear towards COVID-19+ (ORvideo.solo = 0.78, p-val&lt;0.001; ORvideo.friend = 0.79, p-val&lt;0.001) and of stigma (BETAvideo.solo = −0.50, p-val&lt;0.001; BETAvideo.friend = −0.69, p-val&lt;0.001).Conclusion:Video-based interventions lead to reductions in COVID-19-related fear and stigma. No difference in social activity among groups was found, potentially explaining lack of efficacy on loneliness.
Filamentous Fungi Producing l-Asparaginase with Low Glutaminase Activity Isolated from Brazilian Savanna Soil
Authors: Freitas Marcela , Souza Paula , Cardoso Samuel , Cruvinel Kellen , Abrunhosa Letícia Santos , Ferreira Filho Edivaldo X. , Inácio João , Pinho Danilo Batista , Pessoa Adalberto , O. Magalhães Pérola 
Published: August 2021

l-asparaginase is an enzyme used as treatment for acute lymphoblastic leukemia (ALL) due to its ability to hydrolyze l-asparagine, an essential amino acid synthesized by normal cells unlike neoplastic cells. The adverse effects of l-asparaginase formulations are associated with its glutaminase activity and bacterial origin; therefore, it is important to find new sources of l-asparaginase-producing eukaryotic microorganisms with low glutaminase activity. This work evaluated the biotechnological potential of filamentous fungi isolated from Brazilian Savanna soil and plants for l-asparaginase production. Thirty-nine isolates were screened for enzyme production using the plate assay, followed by measuring enzymatic activity in cells after submerged fermentation. The variables influencing l-asparaginase production were evaluated using Plackett–Burman design. Cell disruption methods were evaluated for l-asparaginase release. Penicillium sizovae 2DSST1 and Fusarium proliferatum DCFS10 showed the highest l-asparaginase activity levels and the lowest glutaminase activity levels. Penicillium sizovae l-asparaginase was repressed by carbon sources, whereas higher carbon concentrations enhanced l-asparaginase by F. proliferatum. Maximum enzyme productivity, specific enzyme yield and the biomass conversion factor in the enzyme increased after Plackett–Burman design. Freeze-grinding released 5-fold more l-asparaginase from cells than sonication. This study shows two species, which have not yet been reported, as sources of l-asparaginase with possible reduced immunogenicity for ALL therapy.
Respiration monitoring during 6 min walk using wearable sensor measuring capacitance built across skin
Authors: Karita Momoko , Kumagai Shinya , Sasaki Minoru 
Published: August 2021

Abstract
A wearable respiratory sensor is developed based on capacitance sensing. The conductive cloth electrodes are sewn inside the belly band to give a natural feeling during wear. Respiration is unconsciously monitored using the capacitance built at the skin of the abdomen. Its expansion or contraction generates the capacitance change. Body motion other than respiration can cause noise. The coaxial electrode layout can be insensitive to the twisting body, which is included in the walking motion. Respiration is well monitored during a 6 min walk, which is the standard test in medical diagnoses. With the load of the exercise, metabolism requiring more oxygen is monitored.
A New Broadening Technique of the Numerically Unresolved Solar Transition Region and Its Effect on the Spectroscopic Synthesis Using Coronal Approximation
Authors: Iijima Haruhisa , Imada Shinsuke 
Published: August 2021

Abstract
The transition region is a thin layer of the solar atmosphere that controls the energy loss from the solar corona. Large numbers of grid points are required to resolve this thin transition region fully in numerical modeling. In this study, we propose a new numerical treatment, called LTRAC, which can be easily extended to the multidimensional domains. We have tested the proposed method using a one-dimensional hydrodynamic model of a coronal loop in an active region. The LTRAC method enables modeling of the transition region with a numerical grid size of 50–100 km, which is about 1000 times larger than the physically required value. We used the velocity differential emission measure to evaluate the possible effects on the optically thin emission. Lower-temperature emissions were better reproduced by the LTRAC method than by previous methods. Doppler shift and nonthermal width of the synthesized line emission agree with those from a high-resolution reference simulation within an error of several kilometers per second above the formation temperature of 105 K.
Probing Polarization and the Role of Magnetic Fields in Cloud Destruction in the Keyhole Nebula
Authors: Seo Young Min , Dowell C. Darren , Goldsmith Paul F. , Pineda Jorge L. , Majumdar Liton 
Published: August 2021

Abstract
We present polarimetric observations of the Keyhole Nebula in the Carina Nebula Complex carried out using the Stratospheric Observatory for Infrared Astronomy. The Keyhole Nebula, located to the west of η Carinae, is believed to be disturbed by the stellar winds from the massive star. We observed the Keyhole Nebula at 89 μm wavelength with the HAWC+ instrument. The observations cover the entire Keyhole Nebula spanning 8′ by 5′ with central position R.A. = 10:44:43 and decl. = −59:38:04. The typical uncertainty of polarization measurement is less than 0.5% in the region with intensity above 5500 MJy sr−1. The polarization fraction has a mean value of 2.4% with a standard deviation of 1.6% in the region above this intensity, similar to values in other high-mass star-forming regions. The magnetic field orientation in the bar-shaped structure is similar to the large-scale magnetic field orientation. On the other hand, the magnetic field direction in the loop is not aligned with the large-scale magnetic fields but is tightly aligned with the loop itself. Analysis of the magnetic field angles and the gas turbulence suggests that the field strength is ∼70 μG in the loop. A simple comparison of the magnetic field tension to the ram pressure of η Carinae’s stellar wind suggests that the magnetic fields in the Keyhole Nebula are not strong enough to maintain the current structure against the impact of the stellar wind and that the role of the magnetic field in resisting stellar feedback in this region is limited.
Efficiencies of Magnetic Field Amplification and Electron Acceleration in Young Supernova Remnants: Global Averages and Kepler’s Supernova Remnant
Authors: Reynolds Stephen P. , Williams Brian J. , Borkowski Kazimierz J. , Long Knox S. 
Published: August 2021

Abstract
Particle acceleration to suprathermal energies in strong astrophysical shock waves is a widespread phenomenon, generally explained by diffusive shock acceleration. Such shocks can also amplify the upstream magnetic field considerably beyond simple compression. The complex plasma physics processes involved are often parameterized by assuming that shocks put some fraction ϵ

e
of their energy into fast particles and another fraction ϵ

B
into the magnetic field. Modelers of shocks in supernovae, supernova remnants (SNRs), and gamma-ray bursters, among other locations, often assume typical values for these fractions, presumed to remain constant in time. However, it is rare that enough properties of a source are independently constrained that values of the epsilons can be inferred directly. SNRs can provide such circumstances. Here we summarize results from global fits to spatially integrated emission in six young SNRs, finding 10−4 ≲ ϵ

e
≲ 0.05 and 0.001 ≲ ϵ

B
≲ 0.1. These large variations might be put down to the differing ages and environments of these SNRs, so we conduct a detailed analysis of a single remnant, that of Kepler’s supernova. Both epsilons can be determined at seven different locations around the shock, and we find even larger ranges for both epsilons, as well as for their ratio (thus independent of the shock energy itself). We conclude that unknown factors have a large influence on the efficiency of both processes. Shock obliquity, upstream neutral fraction, or other possibilities need to be explored, while calculations assuming fixed values of the epsilons should be regarded as provisional.
13C Isotopic Ratios of HC3N on Titan Measured with ALMA
Authors: Iino Takahiro , Taniguchi Kotomi , Sagawa Hideo , Tsukagoshi Takashi 
Published: August 2021

Abstract
We present the first determination of the abundance ratios of 13C substitutions of cyanoacetylene (HC3N), [H13CCCN]:[HC13CCN]:[HCC13CN], in Titan’s atmosphere measured using millimeter-wave spectra obtained by the Atacama Large Millimeter/submillimeter Array. To compare the line intensities precisely, data sets that include multiple molecular lines were extracted to suppress effects of Titan’s environmental conditions and observation settings. The [HC13CCN]:[HCC13CN] and [H13CCCN]:[HCC13CN] ratios were obtained from 12 and 1 selected data sets, respectively. As a result, nearly the uniform [H13CCCN]:[HC13CCN]:[HCC13CN] abundance ratios of 1.17 ( ±0.20) : 1.09 ( ±0.25) : 1 (1σ) were derived, whereas previously reported ratios for the interstellar medium (ISM) have shown large anomalies that may be caused by 13C concentrations in precursors. The result obtained here suggests that 13C concentration processes suggested in the ISM studies do not work effectively on precursors of HC3N and HC3N themselves owing to Titan’s high atmospheric temperature and/or depletion of both 13C and 13C+.
Retrospective Analysis of 170 Patients Followed up with Herpes Zoster and Postherpetic Neuralgia in Nothern Cyprus
Authors: Cebeci Dua , Karasel Seide 
Published: August 2021

Herpes zoster is viral infection that occurs with reactivation of the varicella-zoster virus (VZV). It is usually a painful but self-limited dermatomal rash with cutaneous distribution. Although it's usually a painful, self-limiting rash, it can be much more serious; In addition, acute cases often lead to postherpetic neuralgia (PHN) and seriously impair quality of life. It is important to recognize those at risk of developing postherpetic neuralgia, early treatment and prevent complications.
Objectives :Our aim is to determine the clinical features of our herpes zoster diseases and to review the treatments in patients with postherpetic neuralgia.
Methods: A search for HZ and PHN was conducted in a general practice research database, comprising 2 general practices( dermatologist and physatrist) and representing 5600 people. We analyzed a retrospective 170 case series of pediatirc and adults addmited to the dermatology and physical therapy and rehabilitation outpatient clinic between October 2018 and October 2020.
Results: A total of 170 new cases had been diagnosed with HZ in the dermatology and physical therapy and rehabilitation clinics over 2 years . Female to male ratio was 2:1 and the age ranged from 5 years to 88 years. The thoracic dermatomes were the most commonly involved. The risk of developing PHN 1 month after the start of the zoster rash was 21 %. Independent risk indicators for the occurrence of PHN were age [55–74] years.
Conclusion : The risk of developing PHN increases with age and with commorbitity. Preventive strategies such as vaccination should focus on patients with herpes zoster aged >55 years.
Evaluation of apoptotic effect of crocin, cisplatin, and their combination in human oral squamous cell carcinoma cell line HN5
Authors: Bijani Fatima , Zabihi Ebrahim , Bijani Ali , Nouri Hamid Reza , Nafarzadeh Shima , Seyedmajidi Maryam 
Published: August 2021

Background:
Squamous cell carcinoma (SCC) is the most common oral malignancy with high rate of mortality. Cisplatin, as the most effective chemotherapy drug, has side effects. Considering the studies on the use of crocin in saffron in the treatment of various malignancies, this study aimed at investigating the effects of crocin and cisplatin and their combination on SCC and fibroblast cell lines.

Materials and Methods:
In this interventional study, HN5 and fibroblast cell lines were treated with different concentrations of crocin (12.5–50 μg/mL) and cisplatin (2, 4, 8, 16, and 32 μg/mL), and the cells were counted after 24, 48, and 72 h by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Data were analyzed with SPSS Version 17, and P < 0.05 was considered the level of significance. In the final stage, flow cytometry after 24 h in terms of the pattern of cell death was done.

Results:
Both drugs had a toxic effect on malignant cells. One point was the high toxic effect of 8 μg/mL cisplatin not only on cancer cells (P < 0.001) but also on fibroblasts. However, combination with 12.5 μg/mL of crocin had the same effect on HN5 cell line, despite the less toxic effect in fibroblasts in comparison with cisplatin alone (P = 0.012). Apoptosis was the pattern of cell death showed by flow cytometry.

Conclusion:
Crocin in high concentrations can have not only significant toxicity in cancer cells but also side effects in healthy tissue. It seems that lower doses of crocin, in combination with cisplatin, besides having anticancer effect, can reduce the toxicity of cisplatin in healthy tissue.
Basic Health Care Provision Fund Project Implementation
Authors: Adewole David Ayobami , Bello Segun , Okunola Olumide Olaolu , Owoaje Eme Theodora 
Published: August 2021

Introduction:
Knowledge and skills in quantitative/numerical disciplines are some of the essential skills necessary for sustainable and successful administration and management in financing health care. It is not clear whether the personnel across relevant establishments in the health sector of Nigeria have the requisite capacity to implement and manage a performance-based financing project. This survey assessed the availability of certain technical skills among selected mid-level managers in charge of the implementation of the Basic Health Care Provision Fund Project (BHCPFP).

Materials and Methods:
Data were collected with the aid of a self-administered questionnaire developed from a review of the project document. A total population of mid-level managers from all the respective ministries was studied across the six states in Southwest Nigeria. Data collection was conducted between February and June 2019. Data analysis was done using SPSS version 22. Frequency tables were generated and charts were constructed.

Results:
A total of 234 eligible participants were studied. Those who had formal training in quantitative/numerical-based skills such as accounting-related courses were about one-third, 77 (32.8%) and those who had acquired formal training in insurance-related disciplines were 91 (38.7%). A little above one-third, 66 (28.2%) had a form of on-the-job health insurance training.

Conclusions:
This study showed that mid-level managers had poor quantitative-related skills necessary for administrative and technical roles for implementation of BHCPFP. Mid-level managers should be trained and re-trained on those administrative and technical skills for better implementation of BHCPFP.
Notas de Jurisprudencia.- Tribunal Superior de Justicia de Andalucía
Authors: Rivero Ysern José Luis 
Published: August 2021

SUMARIO:
I. ACTO ADMINISTRATIVO. LICENCIA DE PRIMERA OCUPACIÓN.III. BIENES PÚBLICOS. AGUAS. SANCIONES POR CAPTACIÓN DE AGUAS NO AUTORIZADAS. IV. BIENES PÚBLICOS. DOMINIO PÚBLICO MARÍTIMO TERRESTRE. IX. DERECHO ADMINISTRATIVO ECONÓMICO. FOMENTO. REINTEGRO DE SUBVENCIONES.X. DERECHO ADMINISTRATIVO SANCIONADOR.XII. EXPROPIACION FORZOSA . EXPROPIACIONES URBANÍSTICAS. MÉTODO Y SISTEMA DE VALORACIÓN.XX. RESPONSABILIDAD CAUSA EFICIENTE.
Notas de Jurisprudencia.- Tribunal Constitucional
Authors: Escribano López Francisco 
Published: August 2021

SUMARIO:
- Sentencia 14/2020, de 28 de enero (BOE de 29de febrero).Recurso de inconstitucionalidad..- Sentencia 13/2020, de 28 de enero de 2020. Recurso de inconstitucionalidad 976-2019.- Sentencia 15/2020, de 28 de enero de 2020. Cuestión interna de inconstitucionalidad 2754-2019).-Sentencia 16/2020, de 28 de enero de 2020. Recurso de inconstitucionalidad 5530-2019- Sentencia 20/2020, de 10 de febrero de 2020. Cuestión de inconstitucionalidad 4268- 2019- Sentencia 25/2020, de 13 de febrero de 2020. Recurso de inconstitucionalidad 5531-2019..
Noticia de Revistas Autonómicas
Authors: Fernández Ramos Severiano 
Published: August 2021

SUMARIO:
1.- Unión Europea, Comunidades Autónomas, Derecho autonó-mico, Régimen Local.2.- Derechos Fundamentales y derechos de ciudadanía.3.- Fuentes, Potestad Reglamentaria, organización administrativa y Control Jurisdiccional de las Administraciones Públicas. 4.- Acto, procedimiento administrativo y contratación pública. 5.- Empleo, bienes, expropiación y responsabilidad. 5. Modalidades administrativas de Intervención (Policía, Fomento, Servicio público, Actividad Sancionadora, Arbitral y Planificadora).6.- Sectores Administrativos de Intervención. Derecho Administrativo económico. (Aguas, Montes, Minas, Costas, Agricultura y pesca, Urbanismo y Ordenación del territorio, Medio ambiente, Energía, Telecomunicaciones, Patrimonio cultural, etc.).7.- Varia.