bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase-Transition Process in the Hydrothermal Zeolitization of Volcanic Ash into LTA and FAU Structures
Authors: Monzón Jorge D. , Gonzalez Maximiliano R. , Muñoz Mercedes , Pereyra Andrea M. , Basaldella Elena I. 
Published: October 2021

AbstractMinerals such as quartz, present widely in various volcanic ashes, remain unaltered throughout the low-temperature hydrothermal process currently used in industry to obtain zeolites, causing an incomplete hydrothermal transformation of the starting solid. This study presents a novel and cost-effective procedure which improves the reactivity of ash toward the generation of zeolite by increasing the availability of silica and alumina components. This method leads to a final product with a large zeolite content. The transformation consisted of an ash-activation step followed by hydrothermal zeolitization. The influence of the structural, chemical, and morphological characteristics of the volcanic ash as well as the effect of the activation procedure on the ash reactivity were studied. A collected sample (VA) and an amorphous fraction obtained after VA sieving (VA40, retained on #40 mesh) were used for zeolite production. These solids were alkaline-treated separately, aged, and reacted under controlled conditions of temperature at autogenous pressure. Throughout the process, the solid phases were characterized by X-ray diffraction, energy dispersive X-ray microanalysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, and N2adsorption-desorption porosimetry measurements. After activation and alkaline aging, the presence of quartz and plagioclase minerals in the natural ash seemed to improve the growth of NaAlSiO4 polymorphs, which in turn were transformed easily to zeolite structures. Even under adequate pretreatment and suitable synthesis conditions, the coarse non-crystalline fraction led to low conversion, while the highest conversions to zeolites A and X were obtained from the natural ash. The outcomes of the present study could be used to improve the conversion levels of other non-conventional aluminosiliceous minerals into zeolites.
Slices of parameter space for meromorphic maps with two asymptotic values
Authors: CHEN TAO , JIANG YUNPING , KEEN LINDA 
Published: October 2021

AbstractThis paper is part of a program to understand the parameter spaces of dynamical systems generated by meromorphic functions with finitely many singular values. We give a full description of the parameter space for a specific family based on the exponential function that has precisely two finite asymptotic values and one attracting fixed point. It represents a step beyond the previous work by Goldberg and Keen [The mapping class group of a generic quadratic rational map and automorphisms of the 2-shift.Invent. Math.101(2) (1990), 335–372] on degree two rational functions with analogous constraints: two critical values and an attracting fixed point. What is interesting and promising for pushing the general program even further is that, despite the presence of the essential singularity, our new functions exhibit a dynamic structure as similar as one could hope to the rational case, and that the philosophy of the techniques used in the rational case could be adapted.
Boundary maps and maximal representations on infinite-dimensional Hermitian symmetric spaces
Authors: DUCHESNE BRUNO , LÉCUREUX JEAN , POZZETTI MARIA BEATRICE 
Published: October 2021

AbstractWe define a Toledo number for actions of surface groups and complex hyperbolic lattices on infinite-dimensional Hermitian symmetric spaces, which allows us to define maximal representations. When the target is not of tube type, we show that there cannot be Zariski-dense maximal representations, and whenever the existence of a boundary map can be guaranteed, the representation preserves a finite-dimensional totally geodesic subspace on which the action is maximal. In the opposite direction, we construct examples of geometrically dense maximal representation in the infinite-dimensional Hermitian symmetric space of tube type and finite rank. Our approach is based on the study of boundary maps, which we are able to construct in low ranks or under some suitable Zariski density assumption, circumventing the lack of local compactness in the infinite-dimensional setting.
The triangular self in the social media era
Authors: Wang Qi 
Published: October 2021

AbstractI propose a triangular theory of self to characterise the sense of selfhood in the era of social media. According to the theory, the self in the social media era comprises the represented self that is located in the private mind of the person, the registered self that is presented on social media platforms, and the inferred self that is constructed by the virtual audience. The three components of the self interact in dynamic ways to constitute a sense of selfhood and identity specific to the social media era. Autobiographical memory plays a critical role in the development and maintenance of these components. The triangular theory of self introduces new ways to understand and study memory and self in a digitally mediated world.
Do social factors influence perceptions of the jaguar Panthera onca in Ecuador?
Authors: Álvarez Hernán G. , Zapata-Ríos Galo 
Published: October 2021

AbstractIn Latin America, the jaguar Panthera onca is one of the most persecuted and hunted carnivores as a result of its depredation of livestock. In north-west Ecuador jaguar populations are highly threatened, and the largest known population (20–30 individuals) is in El Pambilar Wildlife Refuge, a wet tropical forest surrounded by degraded forests and an agricultural matrix. As the killing of jaguars is one of the main threats to this population, its conservation depends on the perceptions and behaviour of the people living in this region. We interviewed people from 159 households (64% of the total) in eight communities in the buffer zone of the Wildlife Refuge, to examine people's perceptions of any harm caused by jaguars, and to determine the factors that influence these perceptions. In general, people perceived that jaguars caused little harm to their domestic animals or to themselves. However, our models showed that young people with a low level of formal education are the demographic group most likely to hold negative attitudes towards the jaguar, suggesting this group could potentially benefit from involvement in environmental education and awareness programmes.
Visual diplomacy in virtual summitry: Status signalling during the coronavirus crisis
Authors: Danielson August , Hedling Elsa 
Published: October 2021

AbstractOn 26 March 2020, the leaders of the Group of twenty major economies (G20) convened in an emergency virtual meeting to discuss the extraordinary situation facing the world. Virtual summitry provided a stark visual contrast to the traditional staging of modern multilateral diplomacy – leaders were suddenly responsible for their own staging, leaving them with new opportunities to create a favourable impression of how they, and their respective state, would be seen. Taking the disruption of virtual summitry as a starting point, we focus on the resulting new opportunities for visual diplomacy. We draw on the symbolic interactionism of Erving Goffman and we argue that status signalling in this context was based on a shared understanding of the symbols and resources that have social value in the interaction order of summit diplomacy. Based on a visual analysis of 51 photographs from the G20 video conference, we find that the visual performances during the extraordinary meeting reflected evident, but not necessarily intentional, attempts at status seeking. The article thus contributes to an increased understanding of how visual performances contribute to uphold status distinctions in multilateral diplomacy.
Congruences for critical values of higher derivatives of twisted Hasse–Weil L-functions, III
Authors: BLEY WERNER , MACIAS CASTILLO DANIEL 
Published: October 2021

AbstractLetAbe an abelian variety defined over a number fieldk, letpbe an odd prime number and let$F/k$be a cyclic extension ofp-power degree. Under not-too-stringent hypotheses we give an interpretation of thep-component of the relevant case of the equivariant Tamagawa number conjecture in terms of integral congruence relations involving the evaluation on appropriate points ofAof the${\rm Gal}(F/k)$-valued height pairing of Mazur and Tate. We then discuss the numerical computation of this pairing, and in particular obtain the first numerical verifications of this conjecture in situations in which thep-completion of the Mordell–Weil group ofAoverFis not a projective Galois module.
Asymptotics for the number of standard tableaux of skew shape and for weighted lozenge tilings
Authors: Morales Alejandro H. , Pak Igor , Tassy Martin 
Published: October 2021

AbstractWe prove and generalise a conjecture in [MPP4] about the asymptotics of$\frac{1}{\sqrt{n!}} f^{\lambda/\mu}$, where$f^{\lambda/\mu}$is the number of standard Young tableaux of skew shape$\lambda/\mu$which have stable limit shape under the$1/\sqrt{n}$scaling. The proof is based on the variational principle on the partition function of certain weighted lozenge tilings.
Partial Least Squares Analysis of Alzheimer’s Disease Biomarkers, Modifiable Health Variables, and Cognition in Older Adults with Mild Cognitive Impairment
Authors: Stark Jessica , Palombo Daniela J. , Hayes Jasmeet P. , Hiersche Kelly J. , Hasselbach Alexander N. , Hayes Scott M. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: October 2021

ABSTRACTObjectives:To identify novel associations between modifiable physical and health variables, Alzheimer’s disease (AD) biomarkers, and cognitive function in a cohort of older adults with Mild Cognitive Impairment (MCI).Methods:Metrics of cardiometabolic risk, stress, inflammation, neurotrophic/growth factors, AD, and cognition were assessed in 154 MCI participants (Mean age = 74.1 years) from the Alzheimer’s Disease Neuroimaging Initiative. Partial Least Squares analysis was employed to examine associations among these physiological variables and cognition.Results:Latent variable 1 revealed a unique combination of AD biomarkers, neurotrophic/growth factors, education, and stress that were significantly associated with specific domains of cognitive function, including episodic memory, executive function, processing speed, and language, representing 45.2% of the cross-block covariance in the data. Age, body mass index, and metrics tapping basic attention or premorbid IQ were not significant.Conclusions:Our data-driven analysis highlights the significant relationships between metrics associated with AD pathology, neuroprotection, and neuroplasticity, primarily with tasks tapping episodic memory, executive function, processing speed, and verbal fluency rather than more basic tasks that do not require mental manipulation (basic attention and vocabulary). These data also indicate that biological metrics are more strongly associated with episodic memory, executive function, and processing speed than chronological age in older adults with MCI.
Relationship of Purpose in Life to Dementia in Older Black and White Brazilians
Authors: Wilson Robert S. , Capuano Ana W. , Sampaio Carolina , Leurgans Sue E. , Barnes Lisa L. , Boyle Patricia A. , Farfel Jose M. , Bennett David A. 
Published: October 2021

AbstractObjectives:To test the hypothesis that higher level of purpose in life is associated with lower likelihood of dementia and mild cognitive impairment (MCI) in older Brazilians.Methods:As part of the Pathology, Alzheimer’s and Related Dementias Study (PARDoS), informants of 1,514 older deceased Brazilians underwent a uniform structured interview. The informant interview included demographic data, the Clinical Dementia Rating scale to diagnose dementia and MCI, the National Institute of Mental Health Diagnostic Interview Schedule for depression, and a 6-item measure of purpose in life, a component of well-being.Results:Purpose scores ranged from 1.5 to 5.0 with higher values indicating higher levels of purpose. On the Clinical Dementia Rating Scale, 940 persons (62.1%) had no cognitive impairment, 121 (8.0%) had MCI, and 453 (29.9%) had dementia. In logistic regression models adjusted for age at death, sex, education, and race, higher purpose was associated with lower likelihood of MCI (odds ratio = .58; 95% confidence interval [CI]: .43, .79) and dementia (odds ratio = .49, 95% CI: .41, .59). Results were comparable after adjusting for depression (identified in 161 [10.6%]). Neither race nor education modified the association of purpose with cognitive diagnoses.Conclusions:Higher purpose in life is associated with lower likelihood of MCI and dementia in older black and white Brazilians.
Automated Quantitative Image Evaluation of Antigen Retrieval Methods for 17 Antibodies in Placentation and Implantation Diagnostic and Research
Authors: Fuchs Julia , Nonn Olivia , Daxboeck Christine , Groiss Silvia , Moser Gerit , Gauster Martin , Lang-Olip Ingrid , Brislinger Dagmar 
Published: October 2021

Abstract
Immunostaining in clinical routine and research highly depends on standardized staining methods and quantitative image analyses. We qualitatively and quantitatively compared antigen retrieval methods (no pretreatment, pretreatment with pepsin, and heat-induced pretreatment with pH 6 or pH 9) for 17 antibodies relevant for placenta and implantation diagnostics and research. Using our newly established, comprehensive automated quantitative image analysis approach, fluorescent signal intensities were evaluated. Automated quantitative image analysis found that 9 out of 17 antibodies needed antigen retrieval to show positive staining. Heat induction proved to be the most efficient form of antigen retrieval. Eight markers stained positive after pepsin digestion, with β-hCG and vWF showing enhanced staining intensities. To avoid the misinterpretation of quantitative image data, the qualitative aspect should always be considered. Results from native placental tissue were compared with sections of a placental invasion model based on thermo-sensitive scaffolds. Immunostaining on placentas in vitro leads to new insights into fetal development and maternal pathophysiological pathways, as pregnant women are justifiably excluded from clinical studies. Thus, there is a clear need for the assessment of reliable immunofluorescent staining and pretreatment methods. Our evaluation offers a powerful tool for antibody and pretreatment selection in placental research providing objective and precise results.
PTV margin calculation for head and neck patients treated with VMAT: a systematic literature review
Authors: Caruana Kristina , Refalo Nick , Spiteri Denise , Couto José Guilherme , Zarb Frank , Bezzina Paul 
Published: October 2021

AbstractAim:The intent of the review was to identify different methodological approaches used to calculate the planning target volume (PTV) margin for head and neck patients treated with volumetric arc therapy (VMAT), and whether the necessary factors to calculate the margin size with the selected formula were used.Materials and Methods:A comprehensive, systematic search of related studies was done using the Hydi search engine and different databases: MEDLINE, PubMed, CINAHL, ProQuest (Nursing and Allied Health), Scopus, ScienceDirect and tipsRO. The literature search included studies published between January 2007 and December 2020. Eligibility screening was performed by two reviewers.Results:A total of seven studies were found. All the reviewed studies used the Van Herk formula to measure the PTV margin. None of the studies incorporated the systematic errors of target volume delineation in the PTV equation. Inter-fraction translational errors were assessed in all the studies, whilst intra-fraction errors were only included in the margin equation for two studies. The studies showed great heterogeneity in the key characteristics, aims and methods.Findings:Since systemic errors from target volume delineation were not considered and not all studies assess intra-fraction errors, PTV margins may be underestimated. The recommendations are that studies need to determine the effect of target volume variance on PTV margins. It is also recommended to compare PTV margin results using various formulas.
Vanishing Glaciers at Southeast Tibetan Plateau Have Not Offset the Declining Runoff at Yarlung Zangbo
Authors: Wang Yuanwei , Wang Lei , Zhou Jing , Yao Tandong , Yang Wei , Zhong Xiaoyang , Liu Ruishun , Hu Zhidan , Luo Lun , Ye Qinghua , Chen Ningsheng , Ding Haitao 
Published: October 2021

AbstractThe Third Pole experiences accelerated glacier retreating particularly in the eastern‐Himalaya, coinciding with a decrease of monsoon‐precipitation in the early 21st century. The extent to which the vanishing abundant maritime glaciers buffer the declining precipitation‐runoff remains unclear. Here, with a state‐of‐the‐art enthalpy‐based distributed cryosphere‐hydrology model and first‐hand hydrometeorology observations at Motuo (latest accessible Chinese county), we carefully examine the Yarlung Zangbo basin along Himalayas. We find that during 1998–2019, the rising downstream runoff (lower Nuxia; +6.40 × 108 m3/yr) offsets the dropping upstream runoff (upper Nuxia; −6.89 × 108 m3/yr); however, only the marginal contribution from the vanishing eastern‐Himalaya and Nyainqêntanglha glaciers. During 1998–2019, dry upstream illustrates limited glacier melt (15.7 mm/yr) with dominated snow melt (78.8 mm/yr); while much larger at humid downstream (144.8 mm/yr for glacier melt and 219.1 mm/yr for snow melt). From 1981 to 2019, we observe glacier‐to‐snow melt transition in both upstream and downstream due to glacier degradation and growing nonmonsoon‐season precipitation.
DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma
Authors: Gravemeyer Jan , Spassova Ivelina , Verhaegen Monique E. , Dlugosz Andrzej A. , Hoffmann Daniel , Lange Anja , Becker Jürgen C. 
Published: October 2021

AbstractMerkel cell carcinoma (MCC) is a neuroendocrine tumor either induced by integration of the Merkel cell polyomavirus into the cell genome or by accumulation of UV-light-associated mutations (VP-MCC and UV-MCC). Whether VP- and UV-MCC have the same or different cellular origins is unclear; with mesenchymal or epidermal origins discussed. DNA-methylation patterns have a proven utility in determining cellular origins of cancers. Therefore, we used this approach to uncover evidence regarding the cell of origin of classical VP- and UV-MCC cell lines, i.e., cell lines with a neuroendocrine growth pattern (n = 9 and n = 4, respectively). Surprisingly, we observed high global similarities in the DNA-methylation of UV- and VP-MCC cell lines. CpGs of lower methylation in VP-MCC cell lines were associated with neuroendocrine marker genes such as SOX2 and INSM1, or linked to binding sites of EZH2 and SUZ12 of the polycomb repressive complex 2, i.e., genes with an impact on carcinogenesis and differentiation of neuroendocrine cancers. Thus, the observed differences appear to be rooted in viral compared to mutation-driven carcinogenesis rather than distinct cells of origin. To test this hypothesis, we used principal component analysis, to compare DNA-methylation data from different epithelial and non-epithelial neuroendocrine cancers and established a scoring model for epithelial and neuroendocrine characteristics. Subsequently, we applied this scoring model to the DNA-methylation data of the VP- and UV-MCC cell lines, revealing that both clearly scored as epithelial cancers. In summary, our comprehensive analysis of DNA-methylation suggests a common epithelial origin of UV- and VP-MCC cell lines.
Complete loss of miR-200 family induces EMT associated cellular senescence in gastric cancer
Authors: Yu Liang , Cao Can , Li Xu , Zhang Mili , Gu Qisheng , Gao Hugh , Balic Jesse J. , Xu Duogang , Zhang Lei , Ying Le , Xu Dakang , Yang Yuqin , Wu Di , He Baokun , Jenkins Brendan J. , Liu Youdong , Li Jikun 
Published: October 2021

AbstractThe EMT (epithelial-to-mesenchymal-transition) subtype of gastric cancer (GC) is associated with poor treatment responses and unfavorable clinical outcomes. Despite the broad physiological roles of the micro-RNA (miR)-200 family, they largely serve to maintain the overall epithelial phenotype. However, during late-stage gastric tumorigenesis, members of the miR-200 family are markedly suppressed, resulting in the transition to the mesenchymal state and the acquisition of invasive properties. As such, the miR-200 family represents a robust molecular marker of EMT, and subsequently, disease severity and prognosis. Most reports have studied the effect of single miR-200 family member knockdown. Here, we employ a multiplex CRISPR/Cas9 system to generate a complete miR-200 family knockout (FKO) to investigate their collective and summative role in regulating key cellular processes during GC pathogenesis. Genetic deletion of all miR-200s in the human GC cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated β-galactosidase (SA-β−Gal) activity, and aberrant metabolism, collectively resembling the senescent phenotype. Coupling RNA-seq data with publicly available datasets, we revealed a clear separation of senescent and non-senescent states amongst FKO cells and control cells, respectively. Further analysis identified key senescence-associated secretory phenotype (SASP) components in FKO cells and a positive feedback loop for maintenance of the senescent state controlled by activation of TGF-β and TNF-α pathways. Finally, we showed that miR-200 FKO associated senescence in cancer epithelial cells significantly recruited stromal cells in the tumor microenvironment. Our work has identified a new role of miR-200 family members which function as an integrated unit serving to link senescence with EMT, two major conserved biological processes.