bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the transition from more than adequate iodine to adequate iodine on national changes in the prevalence of thyroid disorders: repeat national cross-sectional surveys in China
Authors: Li Yongze , Shan Zhongyan , Teng Weiping 
Published: November 2021

Objective
Longitudinal studies have investigated the effects of changing iodine status on thyroid disorders, but the effect of a transition from more than adequate iodine to adequate iodine on national changes in prevalence adjusted for changing risk factors remains unclear.

Design
Two repeat nationwide surveys were conducted from 2009–2010 to 2015–2017 to assess changes in thyroid disorder prevalence and iodine status in China.

Methods
A multistage stratified random sampling method was used to obtain a nationally representative sample of urban adults aged 18 and older in mainland China in 2009 (n = 14 925) and 2015 (n = 12 553). Changes in thyroid disorder prevalence, urinary iodine concentration (UIC), and thyroid-stimulating hormone (TSH) levels were assessed. Logistic regression models were used to examine changes in prevalence over time.

Results
The median UIC decreased significantly from 219.7 to 175.9 μg/L (P < 0.0001). The weighted prevalence of overt hyperthyroidism, subclinical hyperthyroidism, Graves’ disease, and goitre decreased between 2009 and 2015 in the overall population (P < 0.05 for all). Despite no significant changes in subclinical hyperthyroidism or hypothyroidism or anti-thyroid peroxidase or anti-thyroglobulin antibody positivity prevalence, a significant increase in thyroid nodule prevalence (P < 0.0001) was found in the overall population. The 2.5th TSH percentile increased by 0.15 mIU/L (95% CI: 0.01 to 0.30 mIU/L, P = 0.04) from 2009 to 2015.

Conclusions
With the iodine status transition from more than adequate to adequate, thyroid disorder (except for thyroid nodules) prevalence remained stable or even decreased after adjusting for confounding factors among adults in mainland China between 2009 and 2015. Additional studies are needed to explore the reasons for the increased thyroid nodule prevalence.
Research underpinning the design of an optical sorting plant
Authors: Győrfi Alexandra , Leitol Csaba 
Published: November 2021

Abstract
In the sorting plant examined during the research, the sorting of the selectively collected mixed packaging waste is done by hand. Studies were performed on the quantitative changes of the waste stream entering and leaving the sorting plant, the composition properties according to the particle size, and lastly the number of pickings. The amount of incoming waste has increased linearly over the years. The sizes preferred by the optical separators were the guideline during the measurements. Sixty percentage of all incoming waste falls in the ideal range of 70–350 mm, 20% in the range of <70 mm and 20% in the range of >350 mm. Because there are significant differences in composition and quantities as the seasons and months alternate, these results provide important information for engineers designing a mechanized technology.
Percepción del estrés en estudiantes de odontología ante procedimientos nuevos
Authors: Díaz-Caballero Antonio , Bustillo-Arrieta José , Vergara-Hernández Clara , Casseres-Navarro Jhon , Galvis-Franco Alejandro 
Published: November 2021

Objetivo: identificar los parámetros que afectan el nivel de estrés en los estudiantes de odontología ante prácticas preclínicas y clínicas. Método: estudio descriptivo que buscó instaurar la relación de variables de medidas en una muestra de 150 estudiantes en el periodo 2017-2018, con una participación del 30.6% de estudiantes de 4-5 semestre y 69.4% de estudiantes que pertenecen al componente clínico de 6-9 semestre. Resultados: se definió y caracterizó el concepto de estrés académico desde el enfoque psicológico. Respecto a los factores estresores del componente básico y clínico se evidenció que el 46.6% “algunas veces” ha tenido dificultad para aprender la teoría y al pasar a la práctica carece de conocimientos requeridos en la preclínica y clínica, además que el 44.66% “casi siempre” aducen que la falta de tiempo para llevar a cabo la práctica de procedimientos nuevos, conllevan a factores estresantes. Discusión y conclusiones: el estrés ante procedimientos nuevos se puede asociar a varios factores principalmente a la falta de tiempo para el estudio y la práctica de ciertas actividades odontológicas que más adelante repercutirán en la práctica clínica diaria.
Palabras clave: Estrés, miedo, estudiantes, odontología, salud (DECS-BIREME)
Pencitraan BUMN Dalam Media Online
Authors: Silvana Hana , Kurniawan Harry 
Published: November 2021

ABSTRAK Pada perkembangannya media massa lebih mengarah pada media online. Dalam arus penyebaran informasi media online menjadi lebih luas dan cepat. Penelitian ini bertujuan untuk mendeskripsikan citra perusahaan pada PT.PLN (Persero) pada pemberitaan media online. Penelitian ini menganalisis isi konten pemberitaan terkait perusahaan pada isu subsidi listrik tepat sasaran 2016. Pendekatan penelitian menggunakan penelitian kuantitatif. Metode yang digunakan pada penelitian ini adalah analisis isi. Dari kategori dan indikator yang telah ditentukan, ditemukan bahwa banyak digunakan nada pernyataan buruk pada judul berita namun tidak sama halnya dengan isi konten berita yang cenderung mendapatkan penilaian positif. Hal itu dikarenakan narasumber yang dominan dan terdapat dalam konten pemberitaan merupakan pihak-pihak yang terlibat dalam proses pembuatan kebijakan subsidi listrik tepat sasaran. Hasil penelitian ini dapat disimpulkan bahwa perusahaan PT.PLN (Persero) dalam penelitian ini mendapatkan citra yang positif dari pemberitaan di media online detik.com terkait Isu Subsidi Listrik Tepat Sasaran 2016. Kata Kunci: Citra perusahaan, PLN, Subsidi, Kebijakan ABSTRACT In its development, mass media is more directed at online media. In the flow of information dissemination online media becomes wider and faster. This study aims to describe the company's image to PT. PLN (Persero) on online media coverage. This study analyzes the content of news related content about the company on the issue of electricity subsidies on target 2016. The research approach uses quantitative research. The method used in this study is content analysis. From the categories and indicators that have been determined, it was found that many used bad statement tones in the headline but not the same as the content of news content which tended to get a positive rating. This is because the dominant sources included in the news content are those involved in the process of making electricity subsidy policy on target. The results of this study can be concluded that the company PT PLN (Persero) in this study get a positive image from the news on detik.com online media related to the Issue of the Right Target Electricity Subsidy 2016. Keywords: Company image, PLN, Subsidies, Policy
Strategi Kepala Sekolah dalam Mempersiapkan Pembelajaran Daring di Lingkungan SDN 1 Selaawi Kabupaten Garut
Authors: Hidayat Asep , Mintarsih Mimin 
Published: November 2021

Adanya wabah pandemi yang berlangsung di Indonesia sejak Maret 2020 lalu telah mengubah tatanan kehidupan manusia. Dengan era kehidupan new normal yang mengharuskan semua aktivitas mengikuti protokol kesehatan tertentu dalam pembelajaran diperlukan perencanaan yang memadai. Tujuan penelitian adalah untuk mengetahui bagaimanakah strategi kepala sekolah dalam mempersiapkan pembelajaran daring di lingkungan SDN 1 Selaawi Kecamatan Selaawi Kabupaten Garut. Penelitian ini termasuk penelitian deskriptif kualitatif. Dalam penelitan ini yang menjadi subyek penelitian adalah kepala sekolah SDN 1 Selaawi yang terletak di Kecamatan Selaawi Kabupaten Garut. Penelitian ini dilaksanakan di SD Negeri 1 Selaawi, tepatnya di Desa Selaawi Kecamatan Selaawi Kabupaten Garut. Dalam penelitian ini, digunakan teknik pengumpulan data dengan teknik observasi, wawancara dan dokumentasi. Hasil penelitian yang dilakukan oleh peneliti kepada Kepala Sekolah SDN 1 Selaawi maka dapat dijelaskan bahwa kepala sekolah ini menggunakan strategi yang tepat dalam mempersiapkan pembelajaran daring, berupa analisis kebutuhan terhadap kesiapan siswa, mempersiapkan guru dalam menentukan aplikasi dan dapat menggunakan aplikasi yang ditetapkan, membentuk tim layanan konsultasi pembelajaran daring serta evaluasi. Kesiapan melaksanakan pembelajaran daring tampak dari adanya kesiapan siswa, kesiapan guru, adanya layanan konsultasi dan dilakukan evaluasi.
Modern principles of diagnosis and treatment of patients with neuroendocrine carcinoma of the prostate
Authors: Startsev V. Yu. , Shpof E. V. , Krivonosov D. I. 
Published: November 2021

Background. Prostate cancer (PCa) is well-known as the 2nd leading cause of death from malignant neoplasms among the males from developed countries. One of the variants of the disease - neuroendocrine carcinoma of the prostate (NECP) -manifests itself as the form of castration-resistant PCa. Distinctive manifestations of NECP include a low level of serum prostate specific antigen (PSA), a high potential rate of metastasis, and resistance to hormone replacement therapy. There are very few medical publications on the possibilities of diagnosis and therapy of this type of tumor.The objective of the study is to review the current foundations of pathogenesis, methods of diagnosis and treatment of patients with NECP.Materials and methods. The data of modern medical literature from the PubMed/Crossref archives, from the Elsevier and Scopus databases for 1991-2020 were studied. The materials on the epidemiology and pathogenesis of NECP, as well as the methods of diagnosis and treatment of patients with this pathology are summarized. A comparative analysis of the levels of neuroendocrine markers in castration-resistant and localized forms of PCa was carried out. The schemes of combination therapy of NECP with the use of somatostatin analogs are considered.Results. The detection rate of NECP is reduced due to the blurred clinical picture and morphological characteristics similar to poorly differentiated carcinoma. The basis for the diagnosis of NECP is the determination of the levels of neuronal markers - chromogranin A, neuron-specific enolase, and a number of potentially mitogenic hormones, including PTHrP, NT, serotonin, bombesin, calcitonin, and thyroid-stimulating hormone. The worst prognosis was observed in patients with initially high levels of chromogranin A, which emphasizes the high significance of this indicator for monitoring NECP. The drug of choice in the treatment of patients with this pathology is the somatostatin analogue octreotide-depot, the use of which in combination with hormone replacement therapy leads to stabilization of PCa in 50 % of cases. During therapy with an analogue of somatostatin alone or in cases of tumor progression against the background of chemotherapy, a decrease in PSA level is noted in 50-60 % of cases, and PSA level stabilization - in 41.7-53.3 %.Conclusion. We founded an insufficient number of randomized clinical trials of NECP, therefore, the prognosis of the development of this pathology remains completely unclear. The use of somatostatin analogues, along with targeted therapy, is the main choice of therapy for NECP, but requires further study in the program of randomized trials. If a positive result is obtained, it will be possible to use somatostatin analogs more widely to improve the quality and increase the life expectancy of patients with NECP.
Molecular determinants of recurrences of the human urothelial tumor
Authors: Startsev V. Yu. , Balashov A. E. , Merzlyakov A. S. , Vorobiov S. L. , Kozorezova E. S. 
Published: November 2021

Background. Urothelial carcinoma (UTC) is an aggressive disease with a known propensity for frequent recurrence. It is difficult to predict the velocity of the development of UTC recur using modern means of clinical diagnostics. Therefore, the development of the capabilities of histo-morphological study of tumor tissues is of particular relevance.Materials and methods. The materials of publications (PubMed, CrossRef) for 1990-2021, devoted to the choice of biomarkers for the diagnosis of UTC, the analysis of molecular pathways, progression and metastasis, were studied. The search was carried out for the key phrases "urothelial carcinoma", "recurrent UTK", "stem cells", "biomarkers of bladder cancer", "genetic changes in urothelium", "circulating tumor DNA".Results. Cancer stem cells serve as a source of UTC recurrence after removal from the primary focus, localizing in any areas of the urothelium, as well as outside the main tumor focus and are characterized by a common genotype, but different phenotypic manifestations. To predict the recurrence of the tumour is advisable to use gene expression signatures, since the subtypes of UTC are characterized by clear gene expression profiles. A larger sample and independent dataset is needed to confirm the clinical significance of the findings. Combined biomarkers predict UTC behavior, and FGFR3 and TP53 mutations can be components for a panel for predicting UTC recurrence. The use of the liquid biopsy method with the determination of the level of circulating tumor DNA is a promising diagnostic method that needs to evaluate the results of an initiated randomized trial.Conclusion. The accumulation of knowledge base about the molecular patterns of UTC will help bridge the gap between the results of molecular genetic and clinical diagnostics. Molecular changes in the transitional cell UTC demonstrates a high potential for determining the timing of tumor recurrence, assessing disease-free survival of patients and for planning the resource base of the healthcare system.
Organizing the national prostate cancer audit in the UK (review of foreign literature)
Authors: Andreev D. A. , Zavyalov A. A. 
Published: November 2021

Background. The growing number of patients with prostate cancer (PCa) imposes additional requirements on the quality control system in healthcare, including ensuring the widespread availability of innovative algorithms for early diagnosis and treatment. One illustrative example of quality management initiatives is national PCa audit in the UK. Objective. Highlighting the approaches to quality assessments within audit of PCa care in the UK.Materials and methods. The relevant scientific data have been retrieved from Google and PubMed. The search horizon covered the last 10 years. The queries included such wording as: "prostate cancer" AND "audit" OR/AND "Great Britain" AND "quality assurance", etc.Results. At least four basic parameters were used as signal indicators to check the consistency and overall quality of the collected data on PCa patients in England and Wales. The fundamental arrangement of clinical quality indicators for PCa care comprised not less than fourteen measures. The outliers for some indicators were allocated into two groups using such criteria as: 1) more than three standard deviations from the national average (definition of an alarm); 2) more than two but below three standard deviations from the national average (definition of an alert). The outlier policy is usually applied for three treatment outcome performance indicators.Conclusion. The multidisciplinary teams must actively collaborate to provide the best standards of cancer care to the community. The introduction of multicriterial assessments to monitor the performance of highly specialized professional groups would bring a great benefit for cancer patients, particularly, through increasing the affordability of state-of-the-art medical algorithms across the counties.
Prognosis of patients operated on for renal cell carcinoma and tumor venous thrombosis: experience of the Urology Clinics, N.N. Blokhin National Medical Research Center of Oncology
Authors: Volkova M. I. , Vashakmadze N. L. , Klimov A. V. , Begaliev A. K. , Kuznetsov K. P. , Matveev V. B. 
Published: November 2021

Objective: to identify independent risk factors affecting survival of patients with renal cell carcinoma (RCC) and tumor venous thrombosis who have undergone nephrectomy and thrombectomy.Materials and methods. This study included 768 patients with RCC complicated by tumor venous thrombosis who have undergone nephrectomy and thrombectomy. Median age was 58 years (range: 16-82 years); the male to female ratio was 2.3:1. The symptoms of tumor venous thrombosis were identified in 232 patients (30.2 %); laboratory abnormalities at baseline were observed in 456 patients (59.3 %). Grade I and II tumor thrombosis was diagnosed in 456 (59.3 %) and 201 (26.2 %) patients, respectively; grade III and IV thrombosis was found in 171 (22.3 %) and 177 (23.0 %) patients, respectively. One hundred and twenty-nine participants (16.8 %) had infrarenal inferior vena cava thrombosis. Regional metastases were detected in 188 individuals (24.4 %), distant metastases were registered in 274 patients (35.7 %). All patients have undergone surgery: either radical (n = 555; 72.3 %) or cytoreductive (n = 213; 27.7 %). All primary tumors were histologically classified as RCC (G3-4 in 337 cases; 43.9 %). A total of 719 patients (93.6 %) survived the perioperative period; 183 patients with metastasis (23.8 %) received systemic antitumor therapy.Results. The median follow-up was 24 months (range: 1-200 months). The 24-month overall and cancer-specific survival of all patients were 96.9 and 99.7 %, respectively; recurrence-free survival of patients after radical surgery reached 92.9 %. Progression-free survival among those patients who underwent cytoreductive surgery and received first-line therapy/follow-up was 41.7 %. Negative predictive factors of overall survival included hepatomegaly (p = 0.024), ascites (p = 0.033), level IV tumor thrombosis (p <0.0001), infrarenal inferior vena cava thrombosis (p = 0.002), regional metastases (p <0.0001), and cytoreductive surgery (p = 0.012). Depending on the number of risk factors, we have identified 3 prognostic groups: favorable (0 factors), intermediate (1-2 factors), and poor (3-6 factors). Median overall survival differed significantly between the groups and was 128.6 ± 11.8; 40.9 ± 6.7 and 12.3 ± 2.2 months, respectively (p <0.0001 for all).Conclusion. Stratification of patients operated on for RCC and venous tumor thrombosis with their allocation to prognostic groups will ensure the choice of an optimal management strategy.
Obesity in children with acute lymphoblastic leukemia in remission: the evaluation of causes, hidden nutritional deficiency and the experience of its correction by using artificial enteral nutrition
Authors: Vashura A. Yu. , Zhukovskaya E. V. , Lukina S. S. , Gavrilova A. E. 
Published: November 2021

Background. Antineoplastic treatment can have late toxic manifestations that can often appear after end of treatment. Children after treatment for acute lymphoblastic leukemia (ALL) have a risk of developing both obesity and undernutrition, which may be concealed by increased fat mass.Objective: to explore the incidence of obesity and hidden undernutrition in children with ALL and to describe the effect of enteral feeding using in these children.Materials and methods. In a retrospective study the data of 62 children with obesity that was revealed by standard examination was analyzed. The criterion of obesity was increased value of fat mass received by bioimpedance analysis. For this evaluation Russian bioimpedance analysis standards were used. Additionally, the included data were following: presence of endocrine pathology, weight change during latter 6 months before admission, physical activity and alimentary characteristics (usual regimen and structure of daily feed).Results. Only 54.8 % of patients with an actual excess of fat body mass index detected obesity (Z‑score higher than +2.00) and another 29 % body mass index was within the normal range (Z‑score from –1.00 to +1.00). This was the result of a tissue imbalance: reduce fat‑free mass. Some patients were diagnosed with insulin resistance and hyperinsulinemia. 83.7 % have a completely passive lifestyle. 49.0 % almost do not eat fruits and berries, 79.6 % – vegetables and 91.8 % – fish and seafood. Frequent intake of sweet dishes – 22.4 %, sausage products – 49.0 %, bakery products – 42.9 %, dishes from fast food restaurants – 42.9 %. 55.1 % of patients had more than 5 meals a day, while 18.4 % – less than 3. In or‑ der to correct hidden nutritional deficiencies, 22 patients received artificial nutritional formulas. They had a significant increase in fat‑free mass and a decrease in fat, in comparison with those who did not receive enteral feeding.Conclusion. Treatment‑associated factors, physical activity and alimentary causes play an important role in formation of not only obesity, but also hidden nutritional insufficiency in children with ALL after treatment. Enteral feeding using artificial polymeric formulas showed its effectiveness. An integrated and multidisciplinary approach to solving the problem is appropriate of prevention and treatment of obesity.
Introducing ISMDq—A Web Portal for Real-Time Quality Monitoring of Italian Strong-Motion Data
Authors: Massa Marco , Scafidi Davide , Mascandola Claudia , Lorenzetti Alessio 
Published: November 2021

Abstract
We present the Istituto Nazionale di Geofisica e Vulcanologia Strong-Motion Data-quality (ISMDq)—a new automatic system designed to check both continuous data stream and event strong-motion waveforms before online publication. The main purpose of ISMDq is to ensure accurate ground-motion data and derived products to be rapidly shared with monitoring authorities and the scientific community. ISMDq provides data-quality reports within minutes of the occurrence of Italian earthquakes with magnitude ≥3.0 and includes a detailed daily picture describing the performance of the target strong-motion networks. In this article, we describe and discuss the automatic procedures used by ISMDq to perform its data-quality check.
Before an earthquake, ISMDq evaluates the selected waveforms through the estimation of quality indexes employed to reject bad data and/or to group approved data into classes of quality that are useful to quantify the level of reliability. The quality indexes are estimated based on comparisons with the background ambient noise level performed both in the time and frequency domains. As a consequence, new high- and low-noise reference levels are derived for the overall Italian strong-motion network, for each station, and for groups of stations in the same soil categories of the Eurocode 8 (Eurocode 8 [EC8], 2003).
In absence of earthquakes, 24 hr streaming of ambient noise recordings are analyzed at each station to set an empirical threshold on selected data metrics and data availability, with the goal to build a station quality archive, which is daily updated in a time span of six months.
The ISMDq is accessible online (see Data and Resources) from August 2020, providing rapid open access to ∼10,000 high-quality checked automatically processed strong-motion waveforms and metadata, relative to more than 160 Italian earthquakes with magnitude in the 3.0–5.2 range. Comparisons between selected strong-motion data automatically processed and then manually revised corroborate the reliability of the proposed procedures.