bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobilized Yet Contained: Popular Women, Feminisms, and Organizing around Venezuela’s 2012 Organic Labor Law
Authors: Elfenbein Rachel 
Published: May 2021

Venezuela’s state-led national-popular Bolivarian process opened up a new political field for feminism—an approach that was both institutional and popular, aiming to combine forces from above and from below and use state gender institutions to foment popular women’s organization. Yet this field was conflictual, containing contesting popular feminist projects with different implications for the gendered division of labor. Analysis of popular women’s organizing around Venezuela’s 2012 organic labor law shows that state adoption of feminism marked a gendered political opening for popularizing feminism while also presenting risks of state co-optation of popular women’s organizing. The state understood popular women’s organization and mobilization as central to the revolution, yet it generally attempted to limit their autonomy and organizing to challenge the gendered division of labor. El bolivarianismo nacional-popular liderado por el estado venezolano abrió un nuevo campo político para el feminismo: un enfoque que era tanto institucional como popular y cuyo objetivo era combinar fuerzas tanto de arriba como de abajo, así como utilizar las instituciones estatales de género para fomentar las organizaciones populares de mujeres. Sin embargo, este campo resultó conflictivo, y parte de su contenido impugnaba proyectos feministas populares con diferentes implicaciones para las divisiones de género en el trabajo. El análisis de la organización popular de las mujeres en torno a la ley orgánica del trabajo de Venezuela de 2012 muestra que la adopción estatal del feminismo marcó una apertura política de género con intenciones de popularizar el feminismo a la vez que presentaba el riesgo de que la organización popular de las mujeres fuera cooptada por el estado. El estado consideraba la organización y movilización popular de las mujeres como esenciales a la revolución. Sin embargo y hablando generalmente, se abocó a limitar su autonomía y organización cuando se trataba de desafiar las divisiones de género en el trabajo.
Population Data for Students with Visual Impairments in the United States
Authors: Schles Rachel Anne 
Published: May 2021

Introduction: The purpose of this study was to determine how many young children and students (birth to 22 years old) were identified with visual impairments and receiving special education services in the United States. Professionals estimate at least 50% of students with visual impairments have additional disabilities and are not identified as having a visual impairments for the purposes of the federal Child Count census; therefore, the differences between Child Count and states’ total population counts were explored. Methods: A mixed-methods survey was sent to each U.S. state to determine the total population of students with visual impairments (birth to 22 years old) during the 2016–2017 school year. Results: The 49 responding states reported an average total population four times greater than the number of students with visual impairments than were documented in Child Count data. Many states had limited or no data on their total population of students with visual impairments. Discussion: The findings demonstrate many states are making policy and administrative decisions based on Child Count data not their total population data of students with visual impairments (e.g., planning for 100 students with a primary disability of visual impairments rather than a total population of 405 students with visual impairments). Misuse of Child Count data contributes to underfunding and under-hiring of teachers of students with visual impairments and orientation and mobility instructors. How to address these issues at a systemic level so all students with visual impairments receive appropriate access to resources and quality instruction is also discussed. Implications for practitioners: Practitioners can use available population data across states to educate decision makers at local and state levels regarding the differences between Child Count and total population data for students with visual impairments. Statewide vision programs can also circumvent limited data collection programs at the state level by developing their own systems for total population counts of students with visual impairments.
Evaluation of biomarkers related to zinc nutritional status, antioxidant activity and oxidative stress in rheumatoid arthritis patients
Authors: Duarte Graziela Biude Silva , Callou Kátia Rau de Almeida , Almondes Kaluce Gonçalves de Sousa , Rogero Marcelo Macedo , Pollak Daniel Feldman , Cozzolino Silvia Maria Franciscato 
Published: May 2021

Background: Oxidative stress (OS) is an important process related to the pathophysiology of rheumatoid arthritis and can be increased by the low intake of antioxidants. Zinc (Zn) is an important antioxidant trace-element for human health and the assessment of the nutritional status of this micronutrient in these patients is of relevance. Aim: This study aimed to evaluate Zn nutritional status in rheumatoid arthritis patients and its relation to OS. Methods: A case–control study was carried out with 51 patients diagnosed with rheumatoid arthritis (RA group) recruited in Hospital São Paulo (São Paulo, Brazil) and 55 healthy women (CO group) from the campus of the University of São Paulo. Blood and 24-hour urine collection were used for biochemical parameters related to Zn status and OS. The assessment of dietary Zn was performed by three 24-hour dietary recalls. Results: The RA group presented significative low Zn intake ( p < 0.001) and plasma concentration ( p = 0.040) of this mineral compared to the CO group. However, both groups were Zn deficient and the disease activity (DAS28 score) for RA patients did not influence Zn biomarkers. In addition, the antioxidant enzymes (superoxide dismutase and glutathione peroxidase) activity and the urinary 8-isoprostanes were reduced in RA patients. Conclusion: The evaluation of dietary intake and biochemical biomarkers indicates that rheumatoid arthritis patients are zinc deficient and have increased OS.
A Bayesian Framework for Patient-Level Partitioned Survival Cost-Utility Analysis
Authors: Gabrio Andrea 
Published: May 2021

Patient-level health economic data collected alongside clinical trials are an important component of the process of technology appraisal. For end-of-life treatments, the modeling of cost-effectiveness data may involve some form of partitioned survival analysis, in which measures of quality of life and survival for pre- and postprogression periods are combined to generate aggregate measures of clinical benefits (e.g., quality-adjusted survival). In addition, resource use data are often collected and costs are calculated for each type of health service (e.g., treatment, hospital, or adverse events costs). A critical problem in these analyses is that effectiveness and cost data present some complexities, such as nonnormality, spikes, and missingness, which should be addressed using appropriate methods to avoid biased results. This article proposes a general Bayesian framework that takes into account the complexities of trial-based partitioned survival cost-utility data to provide more adequate evidence for policy makers. Our approach is motivated by, and applied to, a working example based on data from a trial assessing the cost-effectiveness of a new treatment for patients with advanced non–small-cell lung cancer. [Box: see text]
CAG repeats and one polymorphism in androgen receptor gene are associated with renal calcium stone disease
Authors: Basiri Abbas , Naji Mohammad , Houshmand Massoud , Shakhssalim Nasser , Golestan Banafsheh , Azadvari Mohaddeseh , Pakmanesh Hamid , Kashi Amir H 
Published: May 2021

Purpose: Evidence suggests that androgens can be involved in the pathogenesis of renal stones. This study aimed at investigating coding region polymorphisms and CAG repeats in androgen receptor (AR) and their association with active renal calcium stone disease. Materials and Methods: Male patients with calcium kidney stones ( N = 106) with at least two episodes of stone recurrence or size increase during the past 5 years (ASF) were enrolled from December 2008 to April 2009. Control individuals were recruited after matching for age and gender from healthy individuals without current stone or history of stone disease. Genetic sequencing and single strand conformational polymorphism (SSCP) were used to determine AR polymorphisms in the patients and controls. Results: Two polymorphisms were identified in the AR gene: Silent G to A polymorphism in the first exon of the AR gene and C to G polymorphism in intron 4. CAG repeats ranged from 12 to 37. The C/G polymorphism in intron 4 and CAG repeats were associated with the status of active renal calcium stone disease (all p < 0.05). The CC variant of C/G polymorphism was not observed in patients with stone disease. CAG repeats less than 20 and more than 28 were mostly observed in ASF patients ( p < 0.05). Conclusions: CAG repeats and intron 4 C/G polymorphism in the AR gene have an association with renal calcium stone disease.
Socioeconomic Factors Influence Health Information Seeking and Trust Over Time: Evidence From a Cross-Sectional, Pooled Analyses of HINTS Data
Authors: Fareed Naleef , Jonnalagadda Pallavi , Swoboda Christine M. , Samineni Pranav , Griesenbrock Tyler , Huerta Timothy 
Published: May 2021

Purpose: Assessed socioeconomic factors in health information seeking behavior and trust of information sources from 2007 to 2017. Design: Pooled cross-sectional survey data. Setting: Health Information National Trends Survey. Participation: Data included 6 iterations of U.S. adults (Pooled: N = 19,496; 2007: N = 3,593; 2011: N = 3,959; 2013: N = 3,185; FDA 2015: N = 3,738; 2017: N = 3,285; and FDA 2017: N = 1,736). Measures: Outcome variables were health information seeking, high confidence, and high trust of health information from several sources. Independent variables were education and income group, controlling for other sociodemographic variables. Analysis: Weighted descriptive and multivariate logistic regression for the pooled sample assessed associations by education and income. Fully interacted models with education/income-survey year interactions compared differences in outcomes between years. Results: We found information seeking, confidence, and trust were associated with income and education, which supported previously reported findings. Additionally, our findings indicated low-and medium-income groups had significantly lower odds of seeking health information compared to those in a high-income group. Regarding trust of information, a high school education was associated with higher odds of trust in family and friends. We also found that, over time, information seeking, confidence, and trust behavior differed by income and education, with some differences persisting. Conclusion: Disparities by income and education in trust of information sources remained across time. Understanding optimal information sources, their reach, and their credibility among groups could enable more targeted interventions and health messaging. We also describe the implications for our findings in the context of COVID-19.
The mental health of Australian medical practitioners during Covid-19
Authors: Adams Michelle Anne , Brazel Matthew , Thomson Richard , Lake Hannah 
Published: May 2021

Objectives: To ascertain whether doctors were experiencing higher rates of distress during Covid-19 and whether this was impacted by demographic factors. Our hypotheses were that being a junior doctor, having a previous mental health diagnosis and treating Covid-19 positive patients would predict higher rates of distress. Methods: Cross-sectional survey conducted via Survey Monkey. Voluntary participants were recruited from the mailing list of a national-based referral service for doctors to psychiatrists. Distress was measured using the Kessler Psychological Distress Scale (K10). Demographic factors were analysed for predictive value of a higher rating on the K10. Areas of concern in relation to Covid-19 and preference for support services were measured on a Likert scale and compared to levels of distress. Results: The rate of very high distress was 15%. Being a junior doctor and having a previous mental health diagnosis were predictive factors of a higher K10 score. K10 was not affected by likelihood of contact with Covid-19-positive patients. Social isolation had a larger impact on mental health in the context of a previous psychiatric diagnosis. Face-to-face assessments were preferred. Conclusions: Rates of distress in doctors have been higher than baseline during Covid-19. Some groups have been particularly vulnerable.
Amphetamine use and psychiatric admissions: a 10-year perspective
Authors: Nathani Jai , Morris Richard W , Glozier Nicholas , Sara Grant 
Published: May 2021

Objective: We aimed to (i) describe the 10-year trend in admissions associated with amphetamine use, (ii) describe the distinguishing characteristics of people with an amphetamine-related diagnosis (ARD) and (iii) examine predictors of repeated admissions among people with an ARD. Method: We conducted a retrospective cohort study. We (i) counted the number of admissions with an ARD and evaluated any trends, and using univariate and multivariate tests, (ii) compared those who had an ARD with those who did not and (iii) compared those with an ARD who had one, two to four, and five or more admissions. Results: Admissions associated with amphetamine use increased between 2009 and 2015. Those with an ARD had significant differences in demographics, diagnosis and pattern of service use relative to those without an ARD. Amongst those with an ARD, a higher number of admissions was positively associated with a schizophrenia diagnosis but inversely associated with a transient psychotic disorder diagnosis. Conclusions: The increase in admissions associated with amphetamine use indicates that people with an ARD posed major demands on inpatient services. Targeting amphetamine treatment to those with psychotic disorders, both schizophrenia and transient psychotic disorders, may reduce hospital-related costs and re-admissions.
Prenatal Maternal Infections and Children’s Neurodevelopment in the UK Millennium Cohort Study: A Focus on ASD and ADHD
Authors: Hall Hildigunnur Anna , Speyer Lydia Gabriela , Murray Aja Louise , Auyeung Bonnie 
Published: May 2021

Objective: No clear answer has yet been attained as to the influence of prenatal exposure to infection on autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), either alone or as co-occurring issues. The current study examined links between hospital-recorded and maternal-reported prenatal infections and ASD, ADHD, and co-occurring ASD and ADHD. Methods: Participants were n = 15,462 children and mother pairs from the Millennium Cohort Study (MCS), a population-representative UK sample. Results: Findings show associations between maternal-reported infections and ASD, and some evidence of links with ADHD and co-occurring ASD and ADHD. Hospital-recorded infections were not found to be associated with ASD, ADHD, or their co-occurrence. Agreement between hospital-recorded and maternal-reported infections was low, which may explain the discrepant findings. Conclusion: Prenatal maternal infections may be associated with increased odds of ASD and ADHD. Findings point to the importance of drawing on multiple sources of information when ascertaining prenatal infection status.
Parental relationship status and age at autism spectrum disorder diagnosis of their child
Authors: Kalb Luther G , Holingue Calliope , Pfeiffer Danika , Reetzke Rachel , Dillon Emily , Azad Gazi , Freedman Brian , Landa Rebecca 
Published: May 2021

A reliable autism spectrum disorder (ASD) diagnosis can occur as early as 18 months; however, the average age at diagnosis in the United States is over 2 years later. While there are numerous well-known barriers to seeking an ASD diagnosis, no research has examined if separation between a child’s biological parents affects timing of ASD diagnosis for their child. Data for this study were obtained from 561 children ( M age = 5.4 years, SD = 3.9 years) referred to an urban, outpatient ASD specialty clinic for their first ASD evaluation. Biological parents self-reported their relationship status during the evaluation, which was then categorized as either “together” (married or living together but not married) or “not together” (separated, divorced, or never married). An inverse-probability of exposure weighted linear regression model, which adjusted for 16 different child, family, and sociodemographic variables, was utilized to assess differences in child age of ASD diagnosis between groups. At the time of diagnosis, most children’s biological parents were together (69%) versus not together (31%). In the fully adjusted model, children of parents who were together were diagnosed 1.4 years earlier than those who were not together ( p < 0.001). Strategies for supporting these families and reducing age disparities are indicated. Lay abstract Autism spectrum disorder (ASD) can be diagnosed as early as 18 months of age. However, the average age at diagnosis in the United States is over 2 years later. A lot has been written about the many barriers families face when seeking a diagnosis for their child. One area of research that has received no attention is whether separation between a child’s biological parents affects the age at which a child is diagnosed with ASD. This study was conducted among 561 children who were receiving an ASD diagnosis for the first time. On average, these children were 5 years of age. The study took place in an urban, outpatient specialty autism clinic in the United States. Biological parents self-reported their relationship status during the evaluation. This was categorized as either “together” (married or living together but not married) or “not together” (separated, divorced, or never married). At the time of diagnosis, most children’s biological parents were together (69%). We found children of parents who were together were diagnosed 1.4 years earlier than those who were not together. These findings have important implications for providing support to families that separate early in a child’s life, with the goal of reducing the age at ASD evaluation among single parents and those who have been separated from their child’s other biological parent. Providing support to these families is important since earlier age at diagnosis leads to earlier intervention, which can improve long-term outcomes for the child, family, and community as a whole.
Temporal Analysis of Tachycardia During Catheter Directed Thrombolysis for Acute Pulmonary Embolism
Authors: Graif Assaf , Grilli Christopher J. , Scott Amanda L. , Patel Keval D. , Zimmermann Trelawny J. , Wimmer Neil J. , Kimbiris George , Leung Daniel A. 
Published: May 2021

Purpose: To evaluate the effect of catheter directed thrombolysis (CDT) on heart rate (HR) in patients with sinus tachycardia and acute pulmonary embolism (PE). Methods: A retrospective chart review was performed for patients who underwent CDT with tPA for acute massive or submassive PE between 12/2009 and 2/2020. Included were patients who presented with tachycardia at the time of initiation of CDT. Patients with chronic PE, atrial fibrillation, beta blocker therapy, adjunctive endovascular therapy, systemic thrombolysis, or who expired before conclusion of CDT were excluded. HR was measured approximately every hour during CDT. Graphs were plotted of HR as a function of CDT duration. Two interventional radiologists identified the point of plateau (POP) on the graph where CDT had maximized its benefit in decreasing the patient’s HR. Discrepancies were adjudicated by a third interventional radiologist and the median of the 3 measurements was selected. The primary endpoint was the duration of CDT from initiation until the POP. Results: 48 patients were included (52.5 ± 14.7 years, 56.3% female). The POP occurred after 13.1 ± 6.1 hours, by which point HR had been reduced from 110 ± 9.2 bpm to 88 ± 10.6 bpm. Sinus tachycardia was not resolved in 10 patients even though they achieved maximal improvement in HR after 11.3 ± 6.7 hours. Conclusion: Patients presenting with sinus tachycardia related to acute PE achieved maximal, sustained reduction in heart rate from CDT, after approximately 13 hours of infusion. Patients who did not resolve their tachycardia by that point in time were unlikely to resolve it by the conclusion of CDT.
Management of Pancreaticoduodenal Artery Aneurysms Based on a Single-Institution Experience
Authors: Vani Kunal , Calligaro Keith D. , Maloni Krystal , Madden Nicholas , Troutman Douglas A. , Dougherty Matthew J. 
Published: May 2021

Objectives: Pancreaticoduodenal artery aneurysms (PDAAs) are rare and have a high propensity for rupture. Historically, management of PDAAs included surgical reconstruction but has evolved with advances in endovascular therapy. We report our experience with management of PDAAs during the last 30 years. Methods: We retrospectively reviewed our prospectively maintained registry between January 1, 1992 – March 30, 2020. Results: We identified 8 patients with PDAAs: 4 with associated celiac artery occlusive disease and 4 without identifiable etiologies. Four patients were treated with surgical resection of the PDAAs: 2 intact aneurysms underwent concomitant revascularization (superior mesenteric artery-to-hepatic artery Dacron bypass; supra celiac aorta-to-hepatic artery Dacron bypass) and 2 (1 intact, 1 rupture) underwent ligation alone. Four patients were treated with coil embolization of the PDAA: 2 with concomitant stent-graft exclusion of the aneurysm (1 non-rupture, 1 rupture) and 2 without adjunctive measures (intact). There were no deaths nor any significant procedure-related morbidity. Conclusion: Our large single-center experience shows that PDAAs can be successfully treated by open or endovascular intervention with selective revascularization.
Central nervous system-related safety and tolerability of add-on ketamine to antidepressant medication in treatment-resistant depression: focus on the unique safety profile of bipolar depression
Authors: Włodarczyk Adam , Cubała Wiesław J. , Gałuszko-Węgielnik Maria , Szarmach Joanna 
Published: May 2021

Background: There is evidence supporting the use of ketamine in treatment-resistant depression (TRD). However, there are some safety and tolerability concerns associated with ketamine. This study aimed to investigate ketamine’s safety and tolerability to the central nervous system and to assess the relationship between dissociative symptomology and psychometric outcomes during and after intravenous ketamine treatment concurrent with treatment by varying psychotropic medications in treatment-refractory inpatients with major depressive disorder (MDD) and bipolar disorder (BP). Methods: A total of 49 patients with MDD and BP were included in this study. The subjects were administered ketamine and were assessed for changes using an observational protocol. Results: No antidepressants were associated with psychomimetic symptomatology except for citalopram ( p = 0.019). Patients treated with citalopram showed a higher intensity of psychomimetic symptomatology. The use of classic mood-stabilizers was significantly associated with an increase in psychomimetic symptomatology according to the Brief Psychiatric Rating Scale (BPRS; lamotrigine p = 0.009, valproate p = 0.048, lithium p = 0.012). No sequelae were observed. Conclusions: Despite the limitations that this study may be underpowered due to the small sample size, the sample consisted of a heterogeneous TRD population in a single site, and there no blinding of who underwent only acute ketamine administration, our observations indicate ketamine use requires close safety and tolerability monitoring with regards to psychomimetic and dissociative symptoms in TRD-BP and careful management for MDD patients. ClinicalTrials.gov identifier: NCT04226963