bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart
Authors: Li Xiaochen , Meng Cheng , Han Fei , Yang Juhong , Wang Jingyu , Zhu Yanjuan , Cui Xiao , Zuo Minxia , Xu Jie , Chang Baocheng 
Published: March 2021

Aim: Vildagliptin (vild) improves diastolic dysfunction and is associated with a lower relative risk of major adverse cardiovascular events in younger patients. The present study aimed to evaluate whether vild prevents the development of diabetic cardiomyopathy in type 2 diabetic mice and identify its underlying mechanisms.Methods: Type 2 diabetic mouse model was generated using wild-type (WT) (C57BL/6J) and miR-21 knockout mice by treatment with HFD/STZ. Cardiomyocyte-specific miR-21 overexpression was achieved using adeno-associated virus 9. Echocardiography was used to evaluate cardiac function in mice. Morphology, autophagy, and proteins levels in related pathway were analyzed. qRT-PCR was used to detect miR-21. Rat cardiac myoblast cell line (H9c2) cells were transfected with miR-21 mimics and inhibitor to explore the related mechanisms of miR-21 in diabetic cardiomyopathy.Results: Vild restored autophagy and alleviated fibrosis, thereby enhancing cardiac function in DM mice. In addition, miR-21 levels were increased under high glucose conditions. miR-21 knockout DM mice with miR-21 knockout had reduced cardiac hypertrophy and cardiac dysfunction compared to WT DM mice. Overexpression of miR-21 aggravated fibrosis, reduced autophagy, and attenuated the protective effect of vild on cardiac function. In high-glucose-treated H9c2 cells, the downstream effectors of sprouty homolog 1 (SPRY1) including extracellular signal-regulated kinases (ERK) and mammalian target of rapamycin showed significant changes following transfection with miR-21 mimics or inhibitor.Conclusion: The results of our study indicate that vild prevents DCM by restoring autophagy through the miR-21/SPRY1/ERK/mTOR pathway. Therefore, miR-21 is a target in the development of DCM, and vild demonstrates significant potential for clinical application in prevention of DCM.
Growing Up in a Digital World – Digital Media and the Association With the Child’s Language Development at Two Years of Age
Authors: Sundqvist Annette , Koch Felix-Sebastian , Birberg Thornberg Ulrika , Barr Rachel , Heimann Mikael 
Published: March 2021

Digital media (DM), such as cellphones and tablets, are a common part of our daily lives and their usage has changed the communication structure within families. Thus, there is a risk that the use of DM might result in fewer opportunities for interactions between children and their parents leading to fewer language learning moments for young children. The current study examined the associations between children’s language development and early DM exposure.Participants: Ninety-two parents of 25months olds (50 boys/42 girls) recorded their home sound environment during a typical day [Language ENvironment Analysis (LENA)] and participated in an online questionnaire consisting of questions pertaining to daily DM use and media mediation strategies, as well as a Swedish online version of the MacArthur Communicative Development Inventory, which includes a vocabulary scale as well as a grammar and pragmatics scale.Results: Through correlations and stepwise regressions three aspects of language were analyzed. The child’s vocabulary was positively associated with interactional turn-taking. The child’s vocabulary and grammar were negatively associated with the likelihood of parent’s device use during everyday child routines and the amount of TV watched by the child. The child’s pragmatic development was also positively associated with the parent’s device use in child routines but also with the parent’s joint media engagement (JME), as well as the child’s gender (where girls perform better).Conclusion: Our study confirms that specific aspects of the 2-year old’s DM environment are associated with the child’s language development. More TV content, whether it is viewed on a big screen or tablet, is negatively associated with language development. The likelihood of parents’ use of DM during everyday child routines is also negatively associated with the child’s language development. Positive linguistic parental strategies such as interactional turn-taking with the child, JME, and book reading, on the other hand, are positively associated with the child’s language development.
A Proposed Classification of ICD-11 Severity Degrees of Personality Pathology Using the Self and Interpersonal Functioning Scale
Authors: Gamache Dominick , Savard Claudia , Leclerc Philippe , Payant Maude , Berthelot Nicolas , Côté Alexandre , Faucher Jonathan , Lampron Mireille , Lemieux Roxanne , Mayrand Kristel , Nolin Marie-Chloé , Tremblay Marc 
Published: March 2021

Background: The 11th version of the World Health Organization's International Classification of Diseases (ICD-11) has adopted a dimensional approach to personality disorder (PD) nosology. Notably, it includes an assessment of PD degree of severity, which can be classified according to five categories. To date, there is no gold standard measure for assessing degree of PD severity based on the ICD-11 model, and there are no empirically-based anchor points to delineate the proposed categories. With the operationalization of PD degrees of severity in the ICD-11 PD model now being closely aligned with Criterion A of the DSM-5 Alternative Model for Personality Disorders (AMPD), sharing a focus on self and interpersonal dysfunction, self-report instruments developed for the latter model might prove useful as screening tools to determine degrees of severity in the former.Methods: The Self and Interpersonal Functioning Scale, a brief validated self-report questionnaire originally designed to assess level of personality pathology according to the AMPD framework, was used to derive anchor points to delineate the five severity degrees from the ICD-11 PD model. Data from five clinical and non-clinical samples (total N = 2,240) allowed identifying anchor points for classification, based on Receiver Operating Characteristic curve analysis, Latent Class Analysis, and data distribution statistics. Categories were validated using multiple indices pertaining to externalizing and internalizing symptoms relevant to PD.Results: Analyses yielded the following anchor points for PD degrees of severity: No PD = 0–1.04; Personality Difficulty = 1.05–1.29; Mild PD = 1.30–1.89; Moderate PD = 1.90–2.49; and Severe PD = 2.50 and above. A clear gradient of severity across the five categories was observed in all samples. A high number of significant contrasts among PD categories were also observed on external variables, consistent with the ICD-11 PD degree of severity operationalization.Conclusions: The present study provides potentially useful guidelines to determine severity of personality pathology based on the ICD-11 model. The use of a brief self-report questionnaire as a screening tool for assessing PD degrees of severity should be seen as a time-efficient support for clinical decision and treatment planning.
MENGGALI NILAI-NILAI ETIKA SYARIAH PEMBIAYAAN MUDHARABAH
Authors: Rezky Maulida  , Abdul Gafur  , Isna Yuningsih  
Published: March 2021

Tujuan penelitian ini adalah untuk memahami kesadaran etika syariah pelaku perbankan dalam pembiayaan mudarabah bank syariah. Penelitian menggunakan paradigma Islam melalui adopsi pendekatan fenomenologi Islam, melalui wawancara terhadap tiga orang pelaku perbankan BNI Syariah cabang Samarinda dan satu orang ahli fikih. Hasil penelitian menunjukkan bahwa kesadaran etika syariah pelaku perbankan berdasar pada nilai hasanah, dakwah, dan matematika akhirat dalam pemberian layanan pembiayaan mudarabah, melalui kepatuhan terhadap norma syariah yang mengatur akad mudarabah.

Abstract: Exploring the Sharia Ethical Values of Mudharabah Financing. The purpose of this research is to understand the awareness of sharia ethics in banking actors in Islamic bank mudarabah financing. This research uses the Islamic paradigm through the adoption of the Islamic phenomenology approach, through interviews with three BNI Syariah banking actors in the Samarinda branch and one jurisprudence expert. The results show that the awareness of sharia ethics in banking actors is based on the value of hasanah, da'wah, and the hereafter mathematics in providing mudarabah financing services, through compliance with sharia norms that govern the mudarabah contract.
[Reseña] Organización, funcionamiento y gestión de los procesos educativos
Authors: Marqués Donoso Albert 
Published: March 2021

Juan Carlos Sánchez Huete (Coord.) (2021). Organización, funcionamiento y gestión de los procesos educativos. Madrid: CCS, 163 páginas. ISBN: 978-84-1379-014-5
El libro es una recopilación de siete artículos que se centran en cómo se organizan los centros educativos y expone las ramificaciones de la gestión de los procesos educativos. La presente obra expone una serie de conceptos abstractos que tras el devenir de sus páginas se convierten en elementos tangibles como los proyectos educativos...
Strategi Pengembangan Obyek Wisata Negeri Dongeng Sebagai Destinasi Wisata Unggulan Berbasis Taman Wisata Miniatur Tempoe Doeloe
Authors: Susilo Eko Adi , Maknunah Lu'lu Ul 
Published: March 2021

Tourism is one of the major assets that can generate a fairly high source of foreign exchange for the country. Therefore, every area that has certain tourism objects requires regular and sustainable tourism development so that people can take advantage of the existence of tourist destinations in the area. As with the tourism object of the Land of Fairy tales in the area of Kawedusan Ponggok Village, Blitar Regency. The design of this tour is entitled the miniature garden of the wonders of the world which is interesting to visit as a vehicle for education for children. The community can use this as a learning medium and it will have a broad impact on the people around this location to revive the economic sector. This research aims to; (1) Identifying the actual conditions of the current development aspects of the Land of Fairy Tales Tourism. (2) Identifying the influence of the tourism object of the Land of Tales as a vehicle for recreation on tourist visitors and the community around Kawedusan Ponggok Village. (3) Formulating a strategy to develop tourism objects in the Land of Tales as recreational vehicles based on the Tempoe Doeloe tourism park. The research method used by the author in this study is qualitative research and uses a descriptive analysis approach. The results of this study using SWOT analysis techniques can be concluded that the fairy tale tourism development strategy shows that the process of identifying relevant indicators is expected to be able to provide benefits in formulating a tourism development strategy for the Land of Tales in Blitar Regency. Through the formulation of a tourism strategy in a fairy tale country, it is hoped that it will be able to provide benefits to strengthening the competitive bidding position of the concepts offered. It is hoped that this will also be able to provide benefits to strengthening the economic and social aspects of the community at large.
RESPUESTA DE LA CARTA AL EDITOR: SATISFACCIÓN DE USUARIOS EN CONSULTA EXTERNA DE HOSPITALES PÚBLICOS DE LA REGIÓN ICA, 2018.
Authors: BECERRA-CANALES BLADIMIR 
Published: March 2021

Estimado Editor:
En respuesta a la carta al editor respecto al artículo titulado “Satisfacción de usuarios en consulta externa de hospitales públicos de la región Ica, 2018” publicado en el número 3 del volumen 7 del año 2018; de mi autoría, me permito hacer algunas precisiones.
Dado que, el nivel de satisfacción más bajo encontrado en el Hospital Regional de Ica (HRI) y el más alto en el Hospital Apoyo de Nasca (HAN); en la carta al editor se afirma que: “Este resultado se debe a la distancia y equipos que diferencia a estas Instituciones Hospitalarias”. A ese respecto es necesario informar que según la Norma Técnica de Categorización de Establecimientos de Salud del MINSA1, ambas instituciones se diferencian por su nivel de complejidad y el equipamiento depende de la oferta de servicios de salud según la categoría asignada. El HRI, es el nosocomio de mayor complejidad de la región (Mejor equipamiento); por lo tanto, es un hospital referencial, de ahí que las Instituciones Prestadoras de Servicios de Salud (IPRESS) están organizados en función a su nivel de complejidad y el usuario externo consciente de ello, está en la condición de emitir un juicio razonable de su percepción respecto a la satisfacción, más aun si reconocemos que el trato, es el primer aspecto que el usuario toma en cuenta para valorar la calidad de atención; siendo así, la satisfacción del usuario debe ser la misma en una IPRESS del primer o segundo nivel de atención; por ende, el equipamiento y la distancia constituyen posibles factores asociados de la insatisfacción usuaria de ahí que sería prematuro aseverar que: “El traslado de un lugar a otro sea un factor negativo y significativo para medir su satisfacción”; más aún, si no disponemos de un antecedente investigativo previo, en el contexto temporal y espacial donde se realizó el estudio por tratarse de una investigación de nivel descriptivo; no obstante, se sugiere a quienes comparten la misma Línea de Investigación, realizar estudios de nivel relacional y/o explicativo (Desarrollar la Línea de Investigación), para identificar los factores condicionantes de la insatisfacción usuaria o explicar una relación de causalidad entre las variables analizadas.
Sonochemical synthesis of Au/Pd nanoparticles on the surface of LiFePO₄/C cathode material for lithium-ion batteries
Authors: Yoshida Kotaro , Okawa Hirokazu , Ono Yuki , Kato Takahiro , Sugawara Katsuyasu 
Published: March 2021

Abstract
With the aim of investigating the deposition of Au/Pd core–shell nanoparticles (NPs) on cathode materials to decrease charge transfer resistance, Au/Pd core–shell NPs were successfully synthesized and deposited on LiFePO4 coated with carbon (LiFePO4/C) using ultrasound irradiation. Transmission electron microscopy observation confirmed that dispersed Au/Pd NPs with an average particle size of 7.2 nm were deposited on LiFePO4/C. An X-ray diffraction measurement evidenced a peak shifting from 38.2° to 39.1° upon calcination at 400 °C in Ar atmosphere, which can be attributed to the phase transition of the Au/Pd NPs from core–shell to alloy.
Flipped classroom, como herramienta educomunicacional. Un enfoque ante la globalización
Authors: Gutiérrez Gutiérrez Benjamín , Sánchez Lara Jabneel Alejandra 
Published: March 2021

Las herramientas educativas junto con los medios de comunicación cada vez educan diversificadamente al receptor estudiantil a nivel mundial y de todos los niveles educativos, por lo que, la educación como eje articulador de generación de mensajes debe estar orientada a la acción, así como de las corrientes semióticas del estructuralismo formal y de los movimientos constructivistas que abogan por metodologías más abiertas y centradas en el alumno.

La problemática del presente escrito radica en el desfase generacional entre docente-educando, educando – contenidos educativos, así como de las diferentes capacidades humanas de superar entre la concepción de lo académico y no académico. Del mismo modo, los modelos educativos en los que prevalece un proceso unidireccional de la educación, no cubren las necesidades de una sociedad globalizada que exige el uso de inserción educativa del entorno mediático y sociocultural. En ese sentido, plataformas como Flipped Clasroom, al ser herramientas basadas en comunicación permiten proponer en aula nuevas perspectivas educativas con: TICs y TEP a nivel universitario a partir de entornos personales de aprendizaje, con el fin de desarrollar estrategias de enseñanza-aprendizaje a nivel universitario que cumplan con los requisitos impuestos por el constante movimiento, resultado de la globalización y desarrollen así entre otras habilidades, la habilidad oral del inglés. Actualmente la BUAP tiene como objetivo aportar una mejora de la comunidad estudiantil fomentando el intercambio o movilidad estudiantil en diferentes niveles, siendo la internacionalización junto con el inglés aportan una oportunidad para que distintas instituciones se integren a la aldea global.
Percepción de riesgo frente al Covid-19 en adolescentes escolarizados colombianos
Authors: Rosero Bolaños Aldayr David , Carvajal Guachavez Jorge Luis , Bolaños Eduardo Fabio 
Published: March 2021

Se realizó un estudio cuyo objetivo fue determinar los niveles de la percepción de riesgo frente a la nueva enfermedad Covid-19 que presentó una muestra de 296 adolescentes escolarizados de la ciudad de Pasto – Colombia, el muestreo fue no probabilístico de tipo incidental. Se aplicaron de manera virtual dos instrumentos, que fueron un cuestionario socio económico y la escala: Percepción de Riesgo Frente al Covid-19 (PRFC), los cuales se sometieron a análisis estadísticos de tipo descriptivo- correlacional.
Los resultados muestran que la mayoría de participantes (70%) presentan una percepción de riesgo alta y media frente a la enfermedad y sus consecuencias, destacándose el temor a la muerte de un familiar o a enfermar gravemente, también se identificó que los encuestados presentan una baja percepción de riesgo para los componentes relacionados con la probabilidad de contagiarse en situaciones de alta transmisión viral, por lo que no adoptan de manera adecuada las medidas de autocuidado y aislamiento social. Por lo anterior, se concluye que existe una tendencia a percibir el Covid-19 como una enfermedad que pone en riesgo la vida propia y de los demás, sin embargo, se presentan dificultades relacionadas con el desarrollo de hábitos que reduzcan la probabilidad de contagio del virus SARS-Cov-2, causante de la enfermedad ya mencionada.
Exploring the impact of the COVID-19 pandemic on medical learner wellness: a needs assessment for the development of learner wellness interventions
Authors: Cherak Stephana , Brown Allison , Kachra Rahim , Makuk Kira , Sudershan Sanjana , Paget Mike , Kassam Aliya 
Published: March 2021

Background: On March 11, 2020 the World Health Organization declared the novel coronavirus SARS-CoV-2 disease (COVID-19) a global pandemic. We sought to understand impact of COVID-19 on learner wellness at a large tertiary care academic institution to inform the future development of learner wellness interventions during the COVID-19 pandemic.
Methods: A cross-sectional, internet-based survey collected quantitative and qualitative data from learners April-June 2020. Descriptive statistics and univariate analyses were reported for quantitative data. Open-ended, qualitative responses were analyzed deductively using thematic analysis.
Results: Twenty percent of enrolled learners in that faculty of medicine (540/2741) participated including undergraduate [Bachelor’s] students (25.7%), graduate [science] students (27.5%), undergraduate medical students (22.8%), and postgraduate resident physicians (23.5%). We found that learner wellness across all stages of training was negatively impacted and the ways in which learners were impacted varied as a result of their program's response to the COVID-19 pandemic.
Conclusions: Learners in health sciences and medical education report worsening well-being because of the programs and the systems in which they function with the added burden of the COVID-19 pandemic. Future interventions would benefit from a holistic framework of learner wellness while engaging in systems thinking to understand how individuals, programs and respective systems intersect. The importance of acknowledging equity, diversity and inclusion, fostering psychological safety and engaging learners as active participants in their journey during a pandemic and beyond are key elements in developing wellness interventions.
Physiotherapist-led musculoskeletal education: an innovative approach to teach medical students musculoskeletal assessment techniques
Authors: Boulila Cyril , Girouard-Chantal Élise , Gendron Christophe , Lassman Matthew , Dubé Timothy 
Published: March 2021

Implication Statement
We developed physiotherapist-led interprofessional (IP) workshops for medical students each dedicated to a specific anatomical region. The workshops alternated between theoretical presentations from a physiotherapist about basic musculoskeletal (MSK) assessment techniques and hands-on practice in small groups with feedback from Master’s-level physiotherapy students (MPT). The workshops created an optimal IP learning environment where medical students can learn MSK assessment techniques and MPTs can apply their knowledge and clinical skills. Academic institutions with physiotherapy and medical programs seeking to develop IP learning activities should foster opportunities for IP collaboration between physiotherapy and undergraduate medical education.
On the question of setting the level of calculated impact and reliability of high-rise construction
Authors: Zhemchugov-Gitman Dmitry M. , Mozzhukhina Lyubov V. , Uzdin Alexander M. 
Published: March 2021

The question of setting the seismic design input
on high rise buildings is considered. The existing approaches to accounting for
increased responsibility of high rise buildings in Russia are described. The
proposal to reduce the probability of an acceptable building failure in
proportion to the number of floors and Guideline proposals to increase the
reliability factor and using maps of general seismic zoning are analyzed. The
main disadvantages of methods described are indicated. It is shown that the current
regulatory documents in the field of earthquake engineering do not provide the
same reliability of designed structures in general and high-rise buildings in
particular. The influence of seismic dangers in according with seismic zoning
maps on the reliability of the designed objects is noted. An approach to
generating the design input based on the permissible probability of its
exceeding is considered using the example of five five-storey buildings and one
25-storey buildings. The probability of the admissible damage value included in
the normative calculations is estimated. An estimate of the allowable failure
probability on the value of acceptable damage (risk) is proposed under the
assumption of a normal distribution of damage caused by earthquake. It is shown
that the allowable failure probability decreases with decreasing acceptable
damage only in the area of small damages. An approach to the assignment of
seismic action based on an assessment of seismic risk has been formulated. The
system of design coefficients used to calculate seismic loads on high-rise
buildings is analyzed. It is noted that along with an increase in the design
level of seismic acceleration, it is necessary to increase the coefficient,
taking into account the low damping of high-rise buildings oscillations. At the
same time, it is possible to significantly reduce the reduction coefficient by
regulating the strains between the building floors.