bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bereitschaft zur Impfung mit einem COVID‑19-Vakzin – Risikoeinschätzung, Impferfahrungen und Einstellung zu Behandlungsverfahren
Authors: Haug Sonja , Schnell Rainer , Scharf Anna , Altenbuchner Amelie , Weber Karsten 
Published: November 2021

Zusammenfassung
Hintergrund
Impfungen stellen eine bedeutende Präventionsmaßnahme dar. Grundlegend für die Eindämmung der Coronapandemie mittels Durchimpfung der Gesellschaft ist eine ausgeprägte Impfbereitschaft.

Ziel der Arbeit
Die Impfbereitschaft mit einem COVID‑19-Vakzin (Impfstoff gegen das Coronavirus) und deren Einflussfaktoren werden anhand einer Zufallsstichprobe der Gesamtbevölkerung in Deutschland untersucht.

Material und Methoden
Die Studie basiert auf einer telefonischen Zufallsstichprobe und berücksichtigt ältere und vorerkrankte Personen ihrem Bevölkerungsanteil entsprechend. Die Ein-Themen-Bevölkerungsbefragung zur Impfbereitschaft (n = 2014) wurde im November/Dezember 2020 durchgeführt.

Ergebnisse
Die Impfbereitschaft in der Stichprobe liegt bei rund 67 %. Vorerfahrungen mit Impfungen moderieren die Impfbereitschaft. Sie steigt bei Zugehörigkeit zu einer Risikogruppe. Der Glaube an die Wirksamkeit alternativer Heilmethoden und Befürwortung alternativer Behandlungsverfahren geht mit geringerer Impfbereitschaft einher. Ältere Menschen sind impfbereiter, kovariierend mit ihrer Einschätzung höherer Gefährdung bei Erkrankung. Ebenso ist die Ablehnung einer Impfung mit der Überschätzung von Nebenwirkungen assoziiert.

Schlussfolgerung
Die Impfbereitschaft hängt mit Impferfahrungen und Einstellungen zu Gesundheitsbehandlungsverfahren allgemein zusammen. Die Überschätzung der Häufigkeit ernsthafter Nebenwirkungen bei Impfungen weist auf weit verbreitete Fehlinformationen hin.
Major threats to early safety after transcatheter aortic valve implantation in a contemporary cohort of real-world patients
Authors: van Ginkel D. J. , Brouwer J. , van Hemert N. D. , Kraaijeveld A. O. , Rensing B. J. W. M. , Swaans M. J. , Timmers L. , Voskuil M. , Stella P. R. , ten Berg J. M. 
Published: November 2021

Abstract
Introduction
Despite considerable advances in the last decade, major adverse events remain a concern after transcatheter aortic valve implantation (TAVI). The aim of this study was to provide a detailed overview of their underlying causes and contributing factors in order to identify key domains for quality improvement.

Methods
This observational, prospective registry included all patients undergoing TAVI between 31 December 2015 and 1 January 2020 at the St. Antonius Hospital in Nieuwegein and the University Medical Centre in Utrecht. Outcomes of interest were all-cause mortality, stroke, major bleeding, life-threatening or disabling bleeding, major vascular complications, myocardial infarction, severe acute kidney injury and conduction disturbances requiring permanent pacemaker implantation within 30 days after TAVI, according to the Valve Academic Research Consortium‑2 criteria.

Results
Of the 1250 patients who underwent TAVI in the evaluated period, 146 (11.7%) developed a major complication. In 54 (4.3%) patients a thromboembolic event occurred, leading to stroke in 36 (2.9%), myocardial infarction in 13 (1.0%) and lower limb ischaemia in 11 (0.9%). Major bleeding occurred in 65 (5.2%) patients, most frequently consisting of acute cardiac tamponade (n = 25; 2.0%) and major access-site bleeding (n = 21; 1.7%). Most complications occurred within 1 day of the procedure. Within 30 days a total of 54 (4.3%) patients died, the cause being directly TAVI-related in 30 (2.4%). Of the patients who died from causes that were not directly TAVI-related, 14 (1.1%) had multiple hospital-acquired complications.

Conclusion
A variety of underlying mechanisms and causes form a wide spectrum of major threats affecting early safety in 11.7% of patients undergoing TAVI in a contemporary cohort of real-world patients.
Assessment of high enthalpy flow conditions for re-entry aerothermodynamics in the plasma wind tunnel facilities at IRS
Authors: Loehle Stefan , Zander Fabian , Eberhart Martin , Hermann Tobias , Meindl Arne , Massuti-Ballester Bartomeu , Leiser David , Hufgard Fabian , Pagan Adam S. , Herdrich Georg , Fasoulas Stefanos 
Published: November 2021

AbstractThis article presents the full operational experimental capabilities of the plasma wind tunnel facilities at the Institute of Space Systems at the University of Stuttgart. The simulation of the aerothermodynamic environment experienced by vehicles entering the atmosphere of Earth is attempted using three different facilities. Utilizing the three different facilities, the recent improvements enable a unique range of flow conditions in relation to other known facilities. Recent performance optimisations are highlighted in this article. Based on the experimental conditions demonstrated a corresponding flight scenario is derived using a ground-to-flight extrapolation approach based on local mass-specific enthalpy, total pressure and boundary layer edge velocity gradient. This shows that the three facilities cover the challenging parts of the aerothermodynamics along the entry trajectory from Low Earth Orbit. Furthermore, the more challenging conditions arising during interplanetary return at altitudes above 70 km are as well covered.
Meshfree simulation and experimental validation of extreme thermomechanical conditions in friction stir extrusion
Authors: Li Lei , Gupta Varun , Li Xiao , Reynolds Anthony P. , Grant Glenn , Soulami Ayoub 
Published: November 2021

AbstractFriction stir extrusion (FSE) is a novel solid-phase processing technique that consolidates and extrudes metal powders, flakes, chips, or billets into high-performance parts by plastic deformation, which has the potential to save substantial processing time and energy. Currently, most studies on FSE are experimental and only a few numerical models have been developed to explain and predict the complex physics of the process. In this work, a meshfree simulation framework based on smoothed particle hydrodynamics (SPH) was developed for FSE. Unlike traditional grid-based methods, SPH is a Lagrangian particle-based method that can handle severe material deformations, capture moving interfaces and surfaces, and monitor the field variable histories explicitly without complicated tracking schemes. These aspects of SPH make it attractive for the FSE process, where in situ evolution of field variables is difficult to observe experimentally. To this end, a 3-D, fully thermomechanically coupled SPH model was developed to simulate the FSE of aluminum wires. The developed model was thoroughly validated by comparing the numerically predicted material flow, strain, temperature history, and extrusion force with experimental results for a certain set of process parameters. The validated SPH model can serve as an effective tool to predict and better understand the extreme thermomechanical conditions during the FSE process.
Synthesis of a Composite Aerogel of Reduced Graphene Oxide Supported by Two-Dimensional Montmorillonite Nanolayers for Methylene Blue Removal
Authors: Ma Qiulin , Wang Wei , Ge Wei , Xia Ling , Song Shaoxian 
Published: November 2021

AbstractTwo-dimensional montmorillonite nanolayers (2D Mnt) are excellent adsorbents for methylene blue due to the fully exposed active sites, but the separation of 2D Mnt from water is difficult. The objective of the present study was to assemble 2D Mnt and graphene oxide sheets into a three-dimensional aerogel (3D Mnt-rGO Gel) to achieve easy solid–liquid separation. Structural characterization demonstrated that the Mnt-rGO Gel has a porous 3D structure with Mnt nanolayers distributed uniformly within; the introduction of 2D Mnt could reduce significantly the degree of restacking of graphene sheets. Adsorption tests indicated that 2D Mnt enhances the methylene blue (MB) removal performance of Mnt-rGO Gel with a large adsorption capacity of 207 mg g–1, which may be attributed to the adsorption of MB onto 2D Mnt and the increased adsorption surface of rGO resulting from the reduced restacking of graphene sheets. The MB was removed completely by 300 mg L–1 of Mnt-rGO Gel-3 in 180 min. The adsorption process of MB onto Mnt-rGO Gel followed the pseudo-second order kinetic model and the Langmuir isotherm model. Mnt-rGO Gel also showed good reusability. Fourier-transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) results suggested that the adsorption of MB onto Mnt-rGO Gel may be attributed to the π–π interactions between aromatic rings of MB and graphene, hydrogen bonding, and the electrostatic interactions between the nitrogen groups on the MB and oxygen-containing groups on the Mnt-rGO Gel.
Negotiating South–South cooperation for mental health: the World Health Organization and the African Mental Health Action Group, 1970s–90s
Authors: Pringle Yolana 
Published: November 2021

AbstractThis article explores the African Mental Health Action Group (AMHAG), one of the earliest examples of the World Health Organization’s (WHO) attempts to promote ‘ownership’ over development through the South–South cooperation envisaged in Technical Cooperation in Developing Countries. Formed in 1978, the AMHAG was intended to guide national and regional policy on mental health, while also fostering national and collective self-reliance. For a short period, between the late 1970s and the early 1990s, it was central to the WHO’s strategy for promoting policies of mental health in primary healthcare in Africa. It was a largely ineffective tool, with national governments having different opinions on the value of mental health, and poor coordination between AMHAG countries. Approaching the AMHAG as a regional project and transnational network, however, the article provides explores the importance of regions and regionalism in international health cooperation, as well as the inequities of participation in health development. Drawing on WHO archival material spanning over twenty countries and two national liberation movements, it argues that participating countries were differently positioned not only to navigate relationships between countries, but also to contend with the shifting landscape of international assistance, as well as – for some – contexts of war, violence and political and economic instability. The article not only serves as a case study of power imbalances in a failed development initiative, but also sheds light on the WHO’s engagement with mental health during a period that historians of psychiatry in Africa have tended to overlook.
THE SCOPE OF STATE SOVEREIGNTY UNDER ARTICLE 194(2) TFEU AND THE EVOLUTION OF EU COMPETENCES IN THE ENERGY SECTOR
Authors: Huhta Kaisa 
Published: November 2021

AbstractThis article analyses the European Union's competences in the energy sector. It focuses on Article 194(2) of the Treaty on the Functioning of the European Union, which affords EU Member States the right to determine the conditions for exploiting their energy resources, the choice between different energy sources and the general structure of their energy supply. This article traces the constitutional development of EU competences in the energy sector to demonstrate the relevance of Article 194(2) TFEU in the current constitutional, international and sector-specific contexts of EU energy law. It analyses the recent case law of the Court of Justice of the European Union, which shows that the scope of Article 194(2) TFEU is considerably narrower in practice than its wording implies. The article concludes by evaluating the implications of this narrow interpretation on the future development of EU energy law and, in a broader context, on the reach of EU energy and climate policy.
THE CJEU AS THE GATEKEEPER OF INTERNATIONAL LAW: THE CASES OF WTO LAW AND THE AARHUS CONVENTION
Authors: Hadjiyianni Ioanna 
Published: November 2021

AbstractAs the gatekeeper of international law, the CJEU determines the effects not only of international agreements but also decisions of compliance review bodies. This article analyses the Court's engagement with rulings of the WTO dispute settlement bodies (DSB) and findings of the Aarhus Convention Compliance Committee (ACCC). These case studies demonstrate the varied toolkit used by the CJEU to forge relationships with external regimes, while maintaining the EU's autonomy. The CJEU considers DSB reports and ACCC findings selectively and implicitly, demonstrating a qualified openness to international law and a reluctance to engage in a meaningful dialogue with international quasi-judicial bodies.
Validity of the DSM-5 craving criterion for alcohol, tobacco, cannabis, cocaine, heroin, and non-prescription use of prescription painkillers (opioids)
Authors: Shmulewitz D. , Stohl M. , Greenstein E. , Roncone S. , Walsh C. , Aharonovich E. , Wall M. M. , Hasin D. S. 
Published: November 2021

AbstractBackgroundAlthough the DSM-5 was adopted in 2013, the validity of the new substance use disorder (SUD) diagnosis and craving criterion has not been investigated systematically across substances.MethodsAdults (N= 588) who engaged in binge drinking or illicit drug use and endorsed at least one DSM-5 SUD criterion were included. DSM-5 SUD criteria were assessed for alcohol, tobacco, cannabis, cocaine, heroin, and opioids. Craving was considered positive if “wanted to use so badly that could not think of anything else” (severe craving) or “felt a very strong desire or urge to use” (moderate craving) was endorsed. Baseline information on substance-related variables and psychopathology was collected, and electronic daily assessment queried substance use for the following 90 days. For each substance, logistic regression estimated the association between craving and validators, i.e. variables expected to be related to craving/SUD, and whether association with the validators differed for DSM-5 SUD diagnosed with craving as a criterionv.without.ResultsAcross substances, craving was associated with most baseline validators (pvalues<0.05); neither moderate nor severe craving consistently showed greater associations. Baseline craving predicted subsequent use [odds ratios (OR): 4.2 (alcohol) – 234.3 (heroin);p's ⩽ 0.0001], with stronger associations for moderate than severe craving (p's < 0.05). Baseline DSM-5 SUD showed stronger associations with subsequent use when diagnosed with craving than without (p's < 0.05).ConclusionThe DSM-5 craving criterion as operationalized in this study is valid. Including craving improves the validity of DSM-5 SUD diagnoses, and clinical relevance, since craving may cause impaired control over use and development and maintenance of SUD.
Effect of Topographic Degradation on Small Lunar Craters: Implications for Regolith Thickness Estimation
Authors: Yang Xi , Fa Wenzhe , Du Jun , Xie Minggang , Liu Tiantian 
Published: November 2021

AbstractSmall crater morphology method has been used extensively in lunar regolith thickness estimation. However, topographic degradation can change crater morphology and thus bias regolith thickness estimation. In this study, we first developed a shape model for small fresh craters with normal, central mound, flat‐bottomed, and concentric geometry. We then simulated their degradation processes by using a topographic diffusion model. Simulation results show that as a small crater degrades, its morphology changes from concentric/central mound to flat‐bottomed, from flat‐bottomed to normal, and from normal to invisible, depending on its initial morphology. Upon the time a crater becomes invisible, its diameter can be enlarged by a factor of ∼70%. We proposed a revised small crater morphology method and applied it to the Apollo 11 and 14 landing sites. Our revised method permits a more accurate estimate of regolith thickness, and our results are helpful in understanding the evolution of the Moon's surface.
Machine‐Learning Characterization of Tectonic, Hydrological and Anthropogenic Sources of Active Ground Deformation in California
Authors: Hu Xie , Bürgmann Roland , Xu Xiaohua , Fielding Eric , Liu Zhen 
Published: November 2021

AbstractTectonic, hydrological and industrial processes coexist in the dynamic natural environments. However, our knowledge of ground deformation associated with tectonic, hydrological and anthropogenic processes and their interactions remains limited. California represents a natural laboratory that hosts the San Andreas fault system, Central Valley and other aquifer systems, and extensive human extraction of natural resources. The attendant multi‐scale ground deformation that has been mapped using Copernicus Sentinel‐1 Synthetic Aperture Radar (SAR)‐satellite constellation from four ascending and five descending tracks during 2015–2019. We consider the secular horizontal surface velocities and strain rates, constrained from GNSS measurements and tectonic models, as proxies for tectonic processes, and seasonal displacement amplitudes from interferometric SAR (InSAR) time series as proxies for hydrological processes. We synergize 23 types of multidisciplinary datasets, including ground deformation, sedimentary basins, precipitation, soil moisture, topography, and hydrocarbon production fields, using a machine learning algorithm–random forest, and we succeed in predicting 86%–95% of the representative data sets. High strain rates along the SAF system mainly occur in areas with a low‐to‐moderate vegetation fraction (∼0.3), suggesting a correlation of rough/high‐relief coastal range morphology and topography with the active faulting, seasonal and orographic rainfall, and vegetation growth. Linear discontinuities in the long‐term, seasonal amplitude and phase of the surface displacement fields coincide with some fault strands, the boundary zone between the sediment‐fill Central Valley and bedrock‐dominated Sierra Nevada, and the margins of the inelastically deforming aquifer in the San Joaquin Valley, suggesting groundwater flow interruptions, contrasting elastic properties, and heterogeneous hydrological units.
Energy Partitioning, Dynamic Fragmentation, and Off‐Fault Damage in the Earthquake Source Volume
Authors: Johnson Scott E. , Song Won Joon , Vel Senthil S. , Song Bo Ra , Gerbi Christopher C. 
Published: November 2021

AbstractSeismological fracture or breakdown energy represents energy expended in a volume surrounding the advancing rupture front and the slipping fault surface. Estimates are commonly obtained by inverting ground motions and using the results to model slip on the fault surface. However, this practice cannot identify contributions from different energy‐consumption processes, so our understanding of the importance of these processes comes largely from field‐ and laboratory‐based studies. Here, we use garnet fragment size data to estimate surface‐area energy density with distance from the fault core in the damage zone of a deeply exhumed strike‐slip fault/shear zone. Estimated energy densities per fragmentation event range from 2.87 × 103 to 2.72 × 105 J/m3 in the outer and inner portions of the dynamic damage zone, respectively, with the dynamic zone being inferred from the fractal dimensions of fragment size distributions and other indicators. Integrating over the ∼105 m width of the dynamic damage zone gives fracture surface‐area energy per unit fault area ranging from a lower bound of 6.63 × 105 J/m2 to an upper bound of 1.63 × 107 J/m2 per event. This range overlaps with most geological, theoretical, and kinematic slip‐model estimates of energy expenditure in the source volume for earthquakes characterized by seismic moments >1017 N·m. We employ physics‐based fragmentation models to estimate equivalent tensile strain rates associated with garnet fragmentation, which range from 5.42 × 102 to 1.04 × 104 s−1 per earthquake in the outer and inner portions of the dynamic damage zone, respectively. Our results suggest that surface‐energy generation is a nonnegligible component of the earthquake energy budget.
Intraseasonal Variability of the North Equatorial Current Bifurcation Off the Philippines
Authors: Zhou Hui , Liu Xueqi , Li Ruixiang , Wang Yonggang , Yang Guang 
Published: November 2021

AbstractCharacteristics of the intraseasonal variability (ISV) of the North Equatorial Current bifurcation latitude (NBL) are analyzed by using both observations and reanalysis data. The maximum amplitude of the ISV of the NBL can reach about 6° of latitude, which almost triples its annual excursion. The NBL shows a broad spectral peak around 50–140 days with the highest peak occurring around 73 days. Both the Madden‐Julian oscillation and mesoscale eddies have a significant impact on its ISV. A case study for a cyclonic eddy indicates that it can transport about 1.5 Sv (1 Sv–106 m3 s−1) waters to the NBL, and the bifurcation shifts northward with an amplitude of about 8° of latitude in 1 month. Meanwhile, the influence of mesoscale eddies on the ISV of the NBL is highly modulated by the interannual variations of the eddy field. Active eddy activities associated with enhanced barotropic and baroclinic instabilities show a large influence on the NBL. The eddy kinetic energy level around the NBL showed a quite diverse character for the 1997–1998 and the 2015–2016 extreme El Niños, with the latter being double or triple that of the former due to the much stronger vertical and horizontal shears. Given the significant impact on the NBL by the individual eddies and the unevenly distributed cyclonic and anticyclonic eddies around the NBL, the effect of mesoscale eddies on the bifurcation latitude may not cancel each other on seasonal or interannual time scales.
Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
Authors: Deng Jiayin , Gutiérrez Lucía G. , Stoll Gautier , Motiño Omar , Martins Isabelle , Núñez Lucía , Bravo-San Pedro José Manuel , Humeau Juliette , Bordenave Chloé , Pan Juncheng , Fohrer-Ting Hélène , Souquere Sylvie , Pierron Gerard , Hetz Claudio , Villalobos Carlos , Kroemer Guido , Senovilla Laura 
Published: November 2021

AbstractPro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial outer membrane permeabilization (MOMP), which is the rate-limiting step of the intrinsic pathway of apoptosis. Human or mouse cells lacking both BAX and BAK (due to a double knockout, DKO) are notoriously resistant to MOMP and cell death induction. Here we report the surprising finding that BAX/BAK DKO cells proliferate less than control cells expressing both BAX and BAK (or either BAX or BAK) when they are driven into tetraploidy by transient exposure to the microtubule inhibitor nocodazole. Mechanistically, in contrast to their BAX/BAK-sufficient controls, tetraploid DKO cells activate a senescent program, as indicated by the overexpression of several cyclin-dependent kinase inhibitors and the activation of β-galactosidase. Moreover, DKO cells manifest alterations in ionomycin-mobilizable endoplasmic reticulum (ER) Ca2+ stores and store-operated Ca2+ entry that are affected by tetraploidization. DKO cells manifested reduced expression of endogenous sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (Serca2a) and transfection-enforced reintroduction of Serca2a, or reintroduction of an ER-targeted variant of BAK into DKO cells reestablished the same pattern of Ca2+ fluxes as observed in BAX/BAK-sufficient control cells. Serca2a reexpression and ER-targeted BAK also abolished the tetraploidy-induced senescence of DKO cells, placing ER Ca2+ fluxes downstream of the regulation of senescence by BAX/BAK. In conclusion, it appears that BAX/BAK prevent the induction of a tetraploidization-associated senescence program. Speculatively, this may contribute to the low incidence of cancers in BAX/BAK DKO mice and explain why human cancers rarely lose the expression of both BAX and BAK.