bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANIN: Multi-Attention Neural Interaction Networks for Social Rumor Detection
Authors: Jiehu Sun , Yue Wu 
Published: September 2021

Abstract
With the fast-changing development of emerging online media, it has be-come apparent that information on social networks is characterized by extensive, fast and timely spreading. The absence of effective detection methods and moni-toring means has led to a massive outbreak of rumors. Therefore, accurate detection and timely suppression of rumors in social networks is a vital task in maintaining social security and purifying public networks. Most existing work relies only on monotonous textual content and shallow semantic information, and lacks critical at-tention to and potential mining of user relationships. Such being the case, we can better improve these problems by employing attention mechanisms. In this paper, we proposea Multi-Attention Neural Interaction Network (MANIN) for rumor detection, which consists mainly of a self-attention-based BERT encoder, a post-comment co-attention mechanism, and a graph attention neural network for mining potential user interactions. We have conducted numerous experiments on real datasets and verified their validity, and the results show that the model proposed by us outperforms existing models with an accuracy rate of 81.6%.
A Diffeomorphic Aging Model for Adult Human Brain from Cross-Sectional Data
Authors: Thottupattu Alphin J. , Sivaswamy Jayanthi , Krishnan Venkateswaran P. 
Published: September 2021

Abstract
Normative aging trends of the brain can serve as an important reference in the assessment of neurological structural disorders. Such models are typically developed from longitudinal brain image data – follow-up data of the same subject over different time points. In practice, obtaining such longitudinal data is difficult. We propose a method to develop an aging model for a given population, in the absence of longitudinal data, by using images from different subjects at different time points, the so-called cross-sectional data. We define an aging model as a diffeomorphic deformation on a structural template derived from the data and propose a method that develops topology preserving aging model close to natural aging. The proposed model is successfully validated on two public cross-sectional datasets which provide templates constructed from different sets of subjects at different age points.
Treatment of Calcified Lumbar Disc Herniation by Intervertebral Foramen Remolding a Retrospective Study
Authors: Yuan Ao-lin , Shen Xin , Chen Bin 
Published: September 2021

Abstract
Background:

The percutaneous intervertebral foramen mirror technology is a new solution for lumbar disorders. However, like other minimally-invasive treatments for calcified lumbar discs, it is still controversial. The aim of this study was to investigate the use of the percutaneous intervertebral foramen lens technology for secondary molding of the intervertebral foramen in the treatment of calcified lumbar discs.
Methods:

The study included 50 patients aged (mean ± standard deviation) 49.9 ± 14.5 years, 30 (60%) females, who were diagnosed with calcified lumbar disc herniation by computed tomography and magnetic resonance imaging. Patients underwent a percutaneous endoscopic lumbar discectomy surgery in our hospital from January 1, 2017 to December 31, 2019. Demographic characteristics before the surgery and perioperative outcomes were retrospective reviewed. The treatment outcome was analyzed using the visual analog scale (VAS) score, the Oswestry Disability Index score, and modified Macnab criteria.
Results:

We evaluated those patients who showed significant improvement in both the VAS and ODI scores after the surgery and maintained relatively low ODI and VAS scores during subsequent follow-ups. Ninety-four percent of patients rated the results as "excellent" or "good" according to the modified Macnab criteria at the 3-month follow-up. One patient developed neck pain during the surgery, which was diagnosed as spinal hypertension syndrome, and the surgery was suspended until the patient improved. No patient had a dural leak, infection, or other related complications.
Conclusions:

Our results indicate that transforaminal remolding is effective in the treatment of calcified lumbar disc herniations, with few intraoperative and postoperative complications.Our results indicate that secondary reconstruction of the intervertebral foramen under visual conditions using microscopic knife is an effective method for treating calcified lumbar disc herniation, with few intraoperative and postoperative complications.
Prevalence of Metabolic Syndrome Among Adolescents in India: a Population-Based Study
Authors: Ramesh Sowmya , Abraham Ransi Ann , Sarna Avina , Sachdev Harshpal S , Khan Nizamuddin , Porwal Akash , Acharya Rajib , Agrawal Praween K. , Ashraf Sana , Ramakrishnan Lakshmi 
Published: September 2021

Abstract
Background: In India, the prevalence of overweight among adolescents is on the rise, setting the stage for an increase in metabolic syndrome (MS). This paper presents the national prevalence of MS in adolescents in India. Methods: A nationally representative data of adolescents (10–19 years) from the Comprehensive National Nutrition Survey was used. MS was defined based on the NCEP–ATP III criteria for adolescents. Bivariate analysis was used to report socio-demographic differentials in prevalence and to assess interstate variability. Multivariate logistic regression model was constructed to measure the association between socio-demographic characteristics and prevalence of MS. Census data from 2011 was projected to 2017 to calculate burden.Results: The prevalence of MS was 5.2% among adolescents. 11.9%, 15.4%, 26.0%, 31.9% and 3.7% had central obesity, high blood pressure, hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, respectively. The prevalence was higher among males (5.7% vs. 4.7%, adjusted odds ratio (AOR): 1.3, 95% confidence interval [CI]: 1.0, 1.6), those residing in urban areas (7.9% vs 4.2%, AOR: 1.4, 95% CI: 1.1, 1.8), and from wealthier households as compared to their counterparts (8.3% vs. 2.4%, AOR: 3.4, 95% CI: 2.1, 5.5). There was wide interstate variability in the prevalence of MS (0.5% – 16.5%). In 2017, 14.2 million adolescents had MS in India.Conclusions: The prevalence of MS among adolescents in India is low and clustered in urban areas and richer households. Early prevention interventions promoting a healthy lifestyle, especially in high prevalence areas, are needed to keep MS from becoming a public health issue.
Distribution characteristics of SARS-CoV-2 IgM and IgG in false-positive results detected by Chemiluminescent immunoassay
Authors: Lei Yan , Lu Xiaolan , Mou Daiyong , Du Qin , Bin Guo , Guo Xiaolan , Wang Guangrong , Wang Qiang 
Published: September 2021

Abstract
There have been several false-positive results in the antibody detection of the COVID-19. This study aims to analyze the distribution characteristics of SARS-CoV-2 IgM and IgG in false-positive results detected using chemiluminescent immunoassay. The characteristics of the false-positive results in SARS-CoV-2 IgM and IgG testing were retrospectively analyzed. The dynamic changes in the results of SARS-CoV-2 IgM and IgG antibodies were observed. The false-positive proportion of the single SARS-CoV-2 IgM positive results was 95.88%, which was significantly higher than those of the single SARS-CoV-2 IgG positive results (67.50%) (P < 0.001) and SARS-CoV-2 IgM & IgG positive results (29.55%) (P < 0.001). The S/CO of the SARS-CoV-2 IgM and IgG in false-positive results ranged from 1.0 to 50.0. The false-positive probability of SARS-CoV-2 IgM in the S/CO range (1.0 ~ 3.0) was 91.73% (77/84), and the probability of false-positive of SARS-CoV-2 IgG in the S/CO range (1.0 ~ 2.0) was 85.71% (24/28). Dynamic monitoring showed that the S/CO values of IgM in false-positive results decreased or remained unchanged, whereas the S/CO values of IgG in false-positive results only decreased. The possibility of false-positive of the single SARS-CoV-2 IgM positive and single SARS-CoV-2 IgG positive results was high. As the value of S/CO decreased, the probability of false-positive consequently increased, especially among the single SARS-CoV-2 IgM positive results.
Equivalent Inductance Model for the Design Analysis of Electrodynamic Suspension Coils for the Hyperloop
Authors: Lim Jungyoul , Lee Chang-Young , Oh Ye Jun , Jo Jeong-Min , Lee Jin-Ho , Lee Kwan-Sup , Choi Suyong 
Published: September 2021

Abstract
Hyperloop allows for improved transportation efficiency at higher speeds and a lower power consumption. Various magnetic levitation technologies in existing high-speed maglev trains are being considered to overcome speed limitations for the development of Hyperloop, which are driven inside vacuum tubes at 1,200 km/h; and superconducting (SC) electrodynamic suspension (EDS) can provide numerous advantages to Hyperloop. such as enabling stable levitation in high-speed driving without control, and increasing the levitation air gap. However, the analysis of the EDS system requires the electromagnetic transient analysis of complex three-dimensional (3D) features, and its computational load generally limits the use of numerical methods, such as the 3D finite element method (FEM) or dynamic circuit theory; This paper presents a novel model that can rapidly and accurately calculate the frequency-dependent equivalent inductance; and it can model the EDS system with the decoupled resistance-inductance (RL) equations of levitation coils. As a design example, the levitation coils of the SC-EDS were designed and analyzed for the Hyperloop, and the results were compared with those of the FEM results to validate the model. In addition, the model was experimentally validated by measuring currents induced by moving pods.
Complete case logistic regression with a dichotomised continuous outcome: a simulation study
Authors: Cornish Rosaleen Peggy , Bartlett Jonathan William , Macleod John , Tilling Kate 
Published: September 2021

Abstract
Background

A complete case logistic regression will give a biased estimate of the exposure odds ratio only if there is a multiplicative interaction between the exposure and outcome with respect to the probability of missingness – whereas linear regression with a continuous outcome is biased in more scenarios, including when only the outcome causes missingness. It is not clear whether a complete case logistic regression will give a biased estimate of the odds ratio if missingness depends on a continuous outcome but this outcome is dichotomised for the analysis – a common situation in epidemiology.
Methods

We investigated this using a simulation study and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK birth cohort. We also examined whether any bias could be reduced by including a proxy for the binary outcome as an auxiliary variable in multiple imputation.
Results

There was negligible bias in the exposure odds ratio when the probability of being a complete case was independently associated with the exposure and (continuous) outcome but important bias in the presence of an interaction, particularly at high levels of missing data. Inclusion of the proxy led to significant bias reductions when this had high sensitivity and specificity in relation to the study outcome.
Conclusions

The robustness of logistic regression to missing data is maintained even when the outcome is a binary version of a continuous outcome. Bias due to an interaction between the exposure and outcome in their effect on selection could be reduced by including proxies for the missing outcome as auxiliary variables in MI. If such proxies are available, we would recommend using MI over a complete case analysis because, in practice, it would be difficult to rule out an interaction.
Gonadal histology of adult western mosquitofish (Gambusia affinis) following early life exposure to 17α-ethynylestradiol, 17β- trenbolone, and/or atrazine
Authors: Matkin Caroline , Felgenhauer Bruce , Klerks Paul 
Published: September 2021

Abstract
Confined animal feeding operations (CAFOs) are a source of endocrine disrupting compounds (EDCs) in the aquatic environment and introduced there through agricultural runoff and insufficient waste storage systems. This study used the three compounds 17α-ethynylestradiol (EE2), 17β- trenbolone (TB), and atrazine (Atr) alone and in a mixture representing a simulated CAFO runoff. Laboratory exposures were performed in order to assess if early life exposure during the period of sexual differentiation to CAFO runoff altered gonadal development in western mosquitofish (Gambusia affinis). Juveniles were exposed to low and high concentrations of EE2 (50 or 250 ng/L), TB (10 or 50 ng/L), Atr (150 or 1,500 ng/L), or simulated CAFO runoff (50 ng/L EE2, 10 ng/L TB, and 150 ng/L Atr or 250 ng/L EE2, 50 ng/L TB, and 1,500 Atr) for 30-days followed by a 46-day recovery period. Gonadal histology was measured in adult males and females to assess stages of sexual development (i.e., oogenesis or spermatogenesis) and gonadal histopathology. All of the ovaries analyzed were in the maturing or mature stages of oogenesis, and all of the testes examined were in the intermediate or advanced stages of spermatogenesis. Intersex was observed in one individual exposed to 1,500 ng/L Atr. Ovarian histopathology was normal in all females, however testicular histopathology showed a loss of cyst structure leading to unbound interstitial sperm cells and unsynchronized cyst development in all males except the control fish. This study provided some evidence that exposure to simulated CAFO runoff and its individual compounds impaired testicular development.
Information-Sharing Reduces Anxiety Towards Vaccines for SARS-CoV-2 in Patients With Autoimmune Liver Disease
Authors: Kakisaka Keisuke , Suzuki Yuji , Abe Hiroaki , Eto Hisashi , Yusa Kenji , Takikawa Yasuhiro 
Published: September 2021

Abstract
Background: Patients with autoimmune liver disease may feel anxiety towards vaccination for Severe Acute respiratory syndrome coronavirus-2 because of insufficient data regarding its efficacy and adverse effects. The aim of this study was to study how information-sharing regarding coronavirus disease 19 (COVID-19) affects anxiety towards the vaccine in patients with autoimmune liver disease.Methods: Information about COVID-19 and its vaccines provided to subjects with autoimmune liver disease, and change of anxiety to the vaccines after information-sharing were prospectively evaluated.Results: Seventy-one patients prospectively and consecutively registered between March 2021 and May 2021 were assessed. Information-sharing decreased patient anxiety scores towards vaccination from 46 to 23 (p < 0.01). A beneficial effect of information-sharing was confirmed via a visual analog scale (VAS). The correlation of VAS before information-sharing to change of VAS during the study was negative (rho = −0.405, p = 0.00046). There was no significant difference regarding the comparison of VAS to age, or medication use. Conclusion: Information-sharing improved anxiety towards vaccination in patients with autoimmune liver disease, especially in patients who felt strong anxiety before information-sharing.
Discovery of Signature Cyclic Immonium Ion for Lactyllysine Reveals Widespread and Functional Lactylation
on Non-histone Proteins
Authors: Ye Hui , Wan Ning , Wang Nian , Kong Ying , Wang Xinmiao , Wang Dexiang , Yu Siqin , Lu Wenjie , Zhu Yinxue , Yang Chenxi , Shao Chang , Sun Runbin , Wang Nanxi , Hao Haiping 
Published: September 2021

Abstract
Lactylation is a new modification discovered on histones. However, whether it can be installed on non-histone proteins remains unclear. Here we report the formation of a signature cyclic immonium ion of lactyllysine, together with the characteristically changed chromatographic behavior, enabling confident protein lactylation assignment by mass spectrometry. This identification strategy was confirmed by affinity-enriched lactylation proteome and revealed lactylation on nuclear non-histone proteins such as nucleolin. Subsequent exploitation of the approach to mining unenriched, deep proteome resources unveiled an understudied lactylation landscape. From the draft map of the Human Proteome, we identified widespread lactylation on DHRS7 among human tissues, and demonstrated site-directed mutagenesis of the lactylated site affects previously unannotated proteinaceous association. Additionally, the Meltome Atlas showed lactylation frequently occurs on glycolytic enzymes and concomitantly induces thermal stability changes on carrier enzymes. Collectively, the identified signatures of protein lactylation enable confident assignment and allow for the discovery of lactylation proteome expanding beyond histones, representing a step to further understand how lactylation governs cells.
Perspectives of Pain Specialists, Patients, and Family Members on Long-Term Opioid use for Chronic Non- Cancer Pain: A Qualitative Study
Authors: Seangrung Rattaphol , Tempeetikul Thongchai , Pannarunothai Supasit , Sakdanuwatwong Supalak 
Published: September 2021

Abstract
Background: Opioids are currently prescribed for chronic non-cancer pain (CNCP), and some patients use opioids continuously for long-term treatment. Stakeholders’ awareness about long-term opioid therapy is essential for improving the safety and effectiveness of pain treatment. The purpose of this study is to explore the perspectives of pain specialists, patients, and family caregivers about long-term opioid use in CNCP management.Methods: This study was a qualitative study and adhered to the COREQ guidelines. Pain specialists (n = 12), patients (n = 14), and family members (n = 9) were recruited to the study by purposive sampling at the Pain Clinic of Ramathibodi Hospital. Semi-structured interviews were recorded, verbatim transcribed, conceptually coded, and analyzed using Atlas.ti 8.0.Results: All groups of participants described opioids as non-first-line drugs for pain management. Opioids should be prescribed only for severe pain, when non-opioid pharmacotherapy and non-pharmacological therapies are not effective. Patients reported that the benefits of opioids were for pain relief, while physicians and most family members highlighted that opioid use should improve functional outcomes. Physicians and family members expressed concerns about opioid-related side effects, harm, and adverse events, while patients did not. Patients confirmed that they would continue using opioids for pain management under supervision. However, physicians stated that they would taper off or discontinue opioid therapy if patients’ pain relief or functional improvement was not achieved. Both patients and family members were willing to consider non-pharmacological therapies if potential benefits existed. Patient education, doctor–patient/family relationships, and opioid prescription policies were proposed to enhance CNCP management.Conclusion: Long-term opioid therapy for CNCP may be beneficial in patients who have established realistic treatment goals (for both pain relief and functional improvement) with their physicians. Regular monitoring and evaluation of the risks and benefits, adverse events, and drug-related aberrant behaviors are necessary. Integrated multimodal multidisciplinary therapies and family member collaborations are also important for improving CNCP management.
Changing Transmission Dynamics Among Migrant, Indigenous and Mining Populations in a Malaria Hotspot in Northern Brazil: 2016 to 2020
Authors: Wetzler Erica , Marchesini Paola , Villegas Leopoldo , Canavati Sara 
Published: September 2021

Abstract
Background
Roraima state is the northernmost state in Brazil and the primary border-crossing point between Brazil and Venezuela. The uncontrolled surge of malaria in Venezuela, coupled with mass migration of Venezuelans to and from neighbouring countries and the uptick in informal mining in Roraima state, pose a serious threat to the broader region, especially to migrant, indigenous and mining populations, jeopardizing malaria elimination efforts. This study describes changes in the epidemiological profile of malaria in Roraima State related to time, place and populations at risk from 2016 to 2020.
Methods
De-identified malaria surveillance data were obtained from the Malaria Epidemiological Surveillance System from 2016 to 2020. Pearson’s chi-square tested different between imported and autochthonous cases. Multivariable logistic regression was used to identify risk factors for imported versus autochthonous cases by demographic characteristics.
Results
Odds of being an imported case were higher Plasmodium falciparum cases (AOR = 2.08). However, as the number of cases from Venezuela decreased in 2020 following closure of the border, the proportion of Plasmodium falciparum cases increased markedly, from 6.24% in 2019 to 18.50% in 2020. Over the 5-year period, the odds of being an imported case among miners were about nine times higher than the general population (AOR = 8.99). The proportion of total malaria cases that were among indigenous people increased from 33.09% in 2016 to 54.83% in 2020. Indigenous children had a higher burden of malaria with over 40% of cases in children 0 to 9 years old, compared to 8% in non-indigenous children 0 to 9 years old. In some municipalities, place of infection differed from place of notification, with a large proportion of cases in these municipalities reporting in Boa Vista.
Conclusions
Malaria remains a serious threat in Roraima state, especially among high-risk populations, such as miners, migrants, and indigenous people. As malaria cases have increased among indigenous people, miners, and the proportion of Plasmodium falciparum cases has increased, elimination efforts require understanding of these risk factors to tailor interventions appropriately. Furthermore, cross-border surveillance systems need to be urgently strengthened at formal and unofficial border points, especially since the border with Venezuela reopened in July 2021.
Relationship Between Overweight and Obesity and Cardiac Dimensions and Function in a Paediatric Population.
Authors: Cabeza Juan Fernández , Aristizábal-Duque Cristhian H , Sánchez Isabel María Blancas , Ortiz Martín Ruíz , Almodóvar Ana Rodríguez , Ortega Mónica Delgado , Martínez Fátima Esteban , Saldaña Manuel Romero , Pozo Francisco Javier Fonseca del , Álvarez-Ossorio Manuel Pan , Rubio María Dolores Mesa 
Published: September 2021

Abstract
Obesity in adults is associated with left ventricular hypertrophy, dilatation and myocardial fibrosis, as well as heart failure and coronary heart disease. These associations have been studied to a lesser extent in the paediatric population. This study aims to investigate the relationship between obesity and cardiac structure and function in the paediatric population. In a southern Spanish town, we selected all inhabitants aged 6–17 years stratifying by age, gender, and educational centres. We performed a complete transthoracic echocardiogram evaluating all the cardiac morphological and functional parameters commonly measured in an echocardiographic study. There were 212 children and adolescents included. Of them, 48,1 % were males. The mean age was 10.9 ± 3.0 years. 106 (50%) were normal weight, 57 (26.9%) overweight and 49 (23.1%) obese. Sex and age were similar in all three groups. Overweight and obesity were associated with larger left ventricular end-diastolic and end-systolic volumes (p < 0.0005), greater left ventricular mass (p < 0.0005) and smaller ejection fraction (p < 0.0005). They were also associated with larger atrial, aortic and right ventricular size. Lateral and mean E/e' ratios were higher (p = 0.007 and p = 0.01 respectively). Body mass index was independently associated with all cavity size variables as well as left ventricular ejection fraction. Conclusion: Childhood obesity is independently associated with larger heart chambers, greater left ventricle mass, and smaller left ventricle ejection fraction.