bluuebunny/crossref_metadata_2025_split huggingface dataset:
First branchial cleft fistula: a case report and literature review
Authors: Bawazir Razan , Bawazir Abdullah , Bawazir Osama 
Published: September 2021

Abstract
Background
First branchial cleft fistula is a rare malformation of the neck and head. The purpose of this report is to showcase a method of treating first brachial cleft fistula while preserving the facial nerve.

Case presentation
This case report presents an 8-year-old female with a type 2 first branchial cleft fistula. The treatment process follows multidisciplinary approach with the aid of health professionals from different departments, pre-op magnetic resonance imaging (MRI) scanning to map the fistula, and the use of nerve monitoring device (NIM).

Conclusion
The procedure was successfully done while preserving the facial nerve.
Quantum anomalous Hall effect of Dirac half-metal monolayer TiCl3 with high Chern number
Authors: Liu Ze , Yang Guang , Mao Xiujuan , Li Linyang , Li Jia 
Published: September 2021

Abstract
Based on first-principles calculations, monolayer TiCl3 is predicted to be a 100% spin-polarized Dirac half-metal with ferromagnetic Curie temperature T

c
of 63 K as predicted from Monte Carlo simulations. When considering the spin-orbit coupling, the Dirac point in the spin-up opens a ∼3 meV band gap. The calculated result of the anomalous Hall conductivity shows the Chern number

, indicating that three corresponding gapless chiral edge states have emerged inside the bulk gap. Our findings suggest a feasible new member of the quantum anomalous Hall insulator family with promising applications in spintronic devices without dissipation edge states.
The influence of individuals' movement and memory on the evolutionary cooperative behavior
Authors: Zhang Peipei , Li Dandan 
Published: September 2021

Abstract
Considering the influences of individuals' movement and memory, a modified prisoner's dilemma (PD) game model is proposed in this letter. The evolutionary equation of cooperator density is provided in terms of the mean-field theory firstly, and then the proposed model is performed on the lattice network. The numerical results show that if the individual's memory decay factor or memory length is large enough, it is beneficial to promote the cooperation between individuals. Meanwhile, when the population density is neither too dense nor too sparse, cooperative behavior can be effectively promoted. Finally, we show that the emergence of cooperation could be formed due to the movement of individuals. However, when the temptation gain T is extremely large, it is vulnerable to the invasion of cooperators. Our research could have certain enlightenment and reference value on the evolutionary game.
In the Name of the Father? Fertility, Religion, and Child Naming in the Demographic Transition
Authors: Connor Dylan Shane 
Published: September 2021

Abstract
This article shows that parents reveal information about their fertility behavior through how they name their children. I arrive at this finding from a detailed examination of the net fertility of 130,000 married couples in Ireland, a country known for its historically high fertility rate, circa 1911. After stringently accounting for couples' occupation, religion, and location, I find higher fertility rates among couples who chose distinctly Catholic names and traditional names for their children, with the latter being particularly important. Exposure to towns and cities lowered net fertility and weakened preferences for traditional and Catholic names. Cumulatively, these findings highlight the role of traditional rural norms over explicitly religious influences in driving high fertility rates in Ireland. The impact of towns and cities in reducing net fertility suggests that Ireland's sluggish urbanization was a key factor in its high historical fertility rate.
Examining Ethnic Variation in Life Expectancy Among Asians in the United States, 2012–2016
Authors: Baluran Darwin A. , Patterson Evelyn J. 
Published: September 2021

AbstractAs the fastest growing racial group in the United States, understanding the health patterns of Asians is important to addressing health gaps in American society. Most studies have not considered the unique experiences of the ethnic groups contained in the Asian racial group, implying that Asians have a shared story. However, we should expect differences between the ethnic groups given the differences in their timing and place of migration, socioeconomic status, and racialized experiences in the United States. We estimate the life expectancy of the six largest Asian ethnic groups—Chinese, Asian Indians, Filipinos, Vietnamese, Koreans, and Japanese—analyzing data from the Multiple Cause of Death File (2012–2016) and the American Community Survey (2012–2016) in the United States at the national and regional levels. Nationally, Chinese had the highest life expectancy (males e0 = 86.8; females e0 = 91.3), followed by Asian Indians, Koreans, Japanese, Filipinos, and Vietnamese, generally reflecting the pattern expected given their educational attainment, our primary indicator of socioeconomic status. We also found regional differences in life expectancy, where life expectancy for Asians in the West was significantly lower than all other regions. These findings suggest the presence of underlying selection effects associated with settlement patterns among new and traditional destinations. Our results underline the necessity of studying the experiences of the different Asian ethnic groups in the United States, permitting a better assessment of the varying health needs within this diverse racial group.
Inequality in Place: Effects of Exposure to Neighborhood-Level Economic Inequality on Mortality
Authors: Zhao Linda , Hessel Philipp , Simon Thomas Juli , Beckfield Jason 
Published: September 2021

Abstract
This study contributes to the debate on whether income inequality is harmful for health by addressing several analytical weaknesses of previous studies. Using the Panel Study of Income Dynamics in combination with tract-level measures of income inequality in the United States, we estimate the effects of differential exposure to income inequality during three decades of the life course on mortality. Our study is among the first to consider the implications of income inequality within U.S. tracts for mortality using longitudinal and individual-level data. In addition, we improve upon prior work by accounting for the dynamic relationship between local areas and individuals' health, using marginal structural models to account for changes in exposure to local income inequality. In contrast to other studies that found no significant relation between income inequality and mortality, we find that recent exposure to higher local inequality predicts higher relative risk of mortality among individuals at ages 45 or older.
Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength
Authors: Kong Jennifer H. , Young Cullen B. , Pusapati Ganesh V. , Espinoza F. Hernán , Patel Chandni B. , Beckert Francis , Ho Sebastian , Patel Bhaven B. , Gabriel George C. , Aravind L. , Bazan J. Fernando , Gunn Teresa M. , Lo Cecilia W. , Rohatgi Rajat 
Published: September 2021

ABSTRACT
Birth defects result from interactions between genetic and environmental factors, but the mechanisms remain poorly understood. We find that mutations and teratogens interact in predictable ways to cause birth defects by changing target cell sensitivity to Hedgehog (Hh) ligands. These interactions converge on a membrane protein complex, the MMM complex, that promotes degradation of the Hh transducer Smoothened (SMO). Deficiency of the MMM component MOSMO results in elevated SMO and increased Hh signaling, causing multiple birth defects. In utero exposure to a teratogen that directly inhibits SMO reduces the penetrance and expressivity of birth defects in Mosmo−/− embryos. Additionally, tissues that develop normally in Mosmo−/− embryos are refractory to the teratogen. Thus, changes in the abundance of the protein target of a teratogen can change birth defect outcomes by quantitative shifts in Hh signaling. Consequently, small molecules that re-calibrate signaling strength could be harnessed to rescue structural birth defects.
Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis
Authors: Barcus Craig E. , Hwang Priscilla Y. , Morikis Vasilios , Brenot Audrey , Pence Patrick , Clarke Maria , Longmore Gregory D. 
Published: September 2021

ABSTRACT
Both tumor cell-intrinsic signals and tumor cell-extrinsic signals from cells within the tumor microenvironment influence tumor cell dissemination and metastasis. The fibrillar collagen receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) is essential for breast cancer metastasis in mouse models, and high expression of DDR2 in tumor and tumor stromal cells is strongly associated with poorer clinical outcomes. DDR2 tyrosine kinase activity has been hypothesized to be required for the metastatic activity of DDR2; however, inhibition of DDR2 tyrosine kinase activity, along with that of other RTKs, has failed to provide clinically relevant responses in metastatic patients. Here, we show that tyrosine kinase activity-independent action of DDR2 in tumor cells can support Matrigel invasion and in vivo metastasis. Paracrine actions of DDR2 in tumor cells and cancer-associated fibroblasts (CAFs) also support tumor invasion, migration and lung colonization in vivo. These data suggest that tyrosine kinase-independent functions of DDR2 could explain failures of tyrosine kinase inhibitor treatment in metastatic breast cancer patients and highlight the need for alternative therapeutic strategies that inhibit both tyrosine kinase-dependent and -independent actions of RTKs in the treatment of breast cancer.
This article has an associated First Person interview with the first author of the paper.
The neuroethology of avian brood parasitism
Authors: Lynch Kathleen S. 
Published: September 2021

ABSTRACTObligate brood-parasitic birds never build nests, incubate eggs or supply nestlings with food or protection. Instead, they leave their eggs in nests of other species and rely on host parents to raise their offspring, which allows the parasite to continue reproducing throughout the breeding season. Although this may be a clever fitness strategy, it is loaded with a set of dynamic challenges for brood parasites, including recognizing individuals from their own species while growing up constantly surrounded by unrelated individuals, remembering the location of potential host nests for successful reproduction and learning the song of their species while spending time being entirely surrounded by another species during a critical developmental period, a predicament that has been likened to being ‘raised by wolves’. Here, I will describe what we currently know about the neurobiology associated with the challenges of being a brood parasite and what is known about the proximate mechanisms of brood parasite evolution. The neuroethology of five behaviors (mostly social) in brood parasites is discussed, including: (1) parental care (or the lack thereof), (2) species recognition, (3) song learning, (4) spatial memory and (5) pair-bonding and mate choice. This Review highlights how studies of brood parasites can lend a unique perspective to enduring neuroethological questions and describes the ways in which studying brood-parasitic species enhances our understanding of ecologically relevant behaviors.
Cryptochrome-dependent magnetoreception in a heteropteran insect continues even after 24 h in darkness
Authors: Netušil Radek , Tomanová Kateřina , Chodáková Lenka , Chvalová Daniela , Doležel David , Ritz Thorsten , Vácha Martin 
Published: September 2021

ABSTRACT
Sensitivity to magnetic fields is dependent on the intensity and color of light in several animal species. The light-dependent magnetoreception working model points to cryptochrome (Cry) as a protein cooperating with its co-factor flavin, which possibly becomes magnetically susceptible upon excitation by light. The type of Cry involved and what pair of magnetosensitive radicals are responsible is still elusive. Therefore, we developed a conditioning assay for the firebug Pyrrhocoris apterus, an insect species that possesses only the mammalian cryptochrome (Cry II). Here, using the engineered Cry II null mutant, we show that: (i) vertebrate-like Cry II is an essential component of the magnetoreception response, and (ii) magnetic conditioning continues even after 25 h in darkness. The light-dependent and dark-persisting magnetoreception based on Cry II may inspire new perspectives in magnetoreception and cryptochrome research.
Disparities in Breast-Conserving Therapy for Non-Hispanic American Indian/Alaska Native Women Compared with Non-Hispanic White Women
Authors: Erdrich Jennifer , Cordova-Marks Felina , Monetathchi Angela R. , Wu Manxia , White Arica , Melkonian Stephanie 
Published: September 2021

Abstract
Background
Little is known about the surgical patterns of American Indian/Alaska Native (AI/AN) breast cancer patients. The purpose of this study is to determine whether there are disparities in breast cancer surgery and radiation therapy between non-Hispanic AI/AN (NH-AI/AN) women and non-Hispanic White (NHW) women.

Methods
Data from the National Program of Cancer Registries of the Centers for Disease Control and Surveillance, Epidemiology, and End Results were used for this cross-sectional study. Female patients with invasive breast cancer diagnosed 2010–2015 were stratified by race/ethnicity, surgical procedure, radiation, and region. Percentage distributions of mastectomy and lumpectomy were compared overall and by region and stage.

Results
From 2010 to 2015 there were 3292 NH-AI/AN women and 165,225 NHW women diagnosed with breast cancer. For early stage (AJCC stage 1 and 2), NH-AI/AN women had overall significantly higher percentage of mastectomy (41% vs 34.4%, p < 0.001) and significantly lower percentage of lumpectomy (59% vs 65.6%) compared with NHW women, without significant differences in post-lumpectomy radiation (71% vs 70%). There were regional variations, notably in the Northern Plains, where the percentage of mastectomy for early-stage disease was 48.9% for NH-AI/AN women versus 35.9% for NHW women, and in Alaska with 47% for NH-AI/AN women versus 33.3% for NHW women (p < 0.001). There were no overall significant differences in type of surgery or radiation for late-stage disease between groups.

Conclusion
This is the first study to show disparities in surgical management of NH-AI/AN women with breast cancer. For early-stage disease, NH-AI/AN women undergo a higher percentage of mastectomy. Future clinical directions could focus on the factors that drive awareness, decision-making, and access to breast conservation.
Ethics issues identified by applicants and ethics experts in Horizon 2020 grant proposals
Authors: Buljan Ivan , Pina David  G , Marušić Ana 
Published: September 2021

Background: We assessed the ethics review of proposals selected for funding under the Marie Skłodowska-Curie Actions (MSCA) and the European Research Council (ERC) in Horizon 2020, EU’s framework programme for research and innovation, 2014-2020. Methods: We analysed anonymized datasets for 3,054 MSCA individual fellowships (IF), 417 MSCA Innovative Training Networks (ITN), and 1,465 ERC main-listed proposals with ethics conditional clearance, over four years (2016 to 2019). The datasets included the information on ethics issues identified by applicants in their proposal and ethics issues and requirements identified by ethics experts during the ethics review. Results: 42% of proposals received ethical clearance. For proposals with conditional ethics clearance (n=3546), most of the identified ethics issues by both applicants and ethics experts were in the ethics categories related to humans; protection of personal data; environment, health and safety; and non-EU countries. Ethics experts identified twice as many ethics issues compared to applicants across funding schemes, years, and from high- and low-research performing countries. ERC grants had the highest number of ethics requirements per proposal (median (Md)=8, interquartile range (IQR=4-14), compared to ITN (Md=6, IQR=3-13) and IF grants (Md=3, IQR=2-6). The majority of requirements had to be fulfilled after grant agreement: 99.4% for IF, 99.5% for ITN, and 26.0% for ERC. For 9% of the proposals, the requirements included the appointment of an independent ethics advisor and 1% of the proposals had to appoint an ethics advisory board. Conclusions: Many applicants for highly competitive H2020 funding schemes lack awareness of ethics issues raised by their proposed research. There is a need for better training of researchers at all career stages about ethics issues in research, more support to researchers from research organizations to follow the funding agencies requirements, as well as further development and harmonization of the ethics appraisal process during grant assessment.
Type 2 Diabetes Mellitus in Nepal from 2000 to 2020: A systematic review and meta-analysis
Authors: Shrestha Dhan Bahadur , Budhathoki Pravash , Sedhai Yub Raj , Marahatta Achyut , Lamichhane Samit , Nepal Sarbin , Adhikari Anurag , Poudel Ayusha , Nepal Samata , Atreya Alok 
Published: September 2021

Aims: To evaluate the prevalence and risk factors of type 2 diabetes mellitus (T2DM) from 2000-2020 in various parts of Nepal. Methods: PubMed, Embase, Scopus, and Google Scholar were searched using the appropriate keywords. All Nepalese studies mentioning the prevalence of T2DM and/or details such as risk factors were included. Studies were screened using Covidence. Two reviewers independently selected studies based on the inclusion criteria. Meta-analysis was conducted using Comprehensive Meta-Analysis Software v.3. Results: A total of 15 studies met the inclusion criteria. The prevalence of T2DM, pre-diabetes, and impaired glucose tolerance in Nepal in the last two decades was 10% (CI, 7.1%- 13.9%), 19.4% (CI, 11.2%- 31.3%), and 11.0% (CI, 4.3%- 25.4%) respectively. The prevalence of T2DM in the year 2010-15 was 7.75% (CI, 3.67-15.61), and it increased to 11.24% between 2015-2020 (CI, 7.89-15.77). There were 2.19 times higher odds of having T2DM if the body mass index was ≥24.9 kg/m2. Analysis showed normal waist circumference, normal blood pressure, and no history of T2DM in a family has 64.1%, 62.1%, and 67.3% lower odds of having T2DM, respectively. Conclusion: The prevalence of T2DM, pre-diabetes, and impaired glucose tolerance in Nepal was estimated to be 10%, 19.4%, and 11% respectively.
Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder
Authors: Lumbanraja Sarma , Yaznil M Rizki , Siahaan Andre M , Berry Eka Parda Bancin 
Published: September 2021

Background: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not fully understood. Soluble fms-like tyrosine kinase-1 (sflt-1) as a protein produced by the placenta was found to be decreased in placenta accreta, Therefore we aim to see if sfltsFlt-1 has a role in the development of placenta accreta. Methods: This study involved 40 samples from patients that had been diagnosed with placenta accreta spectrum disorder (case group), and 40 samples from patients with normal pregnancies (control group) at Rumah Skit Umum Pusat H.Adam Malik (RSUP) Haji Adam Malik Medan, in Indonesia. Diagnosis of placenta accreta syndrome was based on Placenta Accreta Spectrum Score (PAS), and International Federation of Gynecology and Obstetrics (FIGO) classification of placenta accreta spectrum disorder.Analyses were performed by independent t-test, man Mann-Whitney U test, and Kruskal-Wallis analysis test, with a P-value <0.05 considered as statistically significant (95%CI). Results: Based on this study, we found that the sFlt-1 level in the case group was lower than the control group. Data analysis using the Kruskal-Wallis test showed that there was a difference in sFlt-1 levels in this study group (p = 0.02), which was further evaluated with post hoc analysis using Mann. -Whitney U test. The results indicated that there were significant differences between the control and PAS 0, PAS1, and PAS 2 (p = 0.043; p = 0.002; p = 0.03). Conclusion: sFlt-1 levels decreased in placental invasive pregnancies compared to normal pregnancies, however, this still needs to be investigated further in a multi-center study, considering that sFlt-1 levels are also influenced by ethnicity and other conditions that cannot be excluded in this study.
Doctoral Studies as part of an Innovative Training Network (ITN): Early Stage Researcher (ESR) experiences
Authors: Biswas Roshni , Schiller Axel , Casolani Chiara , Daoud Elza , Dode Albi , Genitsaridi Eleni , Jacquemin Laure , Liyanage Nuwan , Lourenco Matheus , Makani Punitkumar , Parameshwarappa Vinay , Riha Constanze , L Santacruz Jose , Shabbir Maryam , Simoes Jorge , Trpchevska Natalia , Schoisswohl Stefan 
Published: September 2021

Background: The Marie-Skłodowska-Curie Actions’ (MSCA) Innovative Training Network (ITN) is a doctoral training programme jointly implemented by academic institutions and industries from countries across Europe and beyond. To our knowledge no study has examined the experience of students participating in MSCA-ITNs. This study aims to evaluate and report MSCA-ITN Early Stage Researcher (ESR) experiences. Methods: The Innovative Training Network - Evaluation Questionnaire (ITN-EQ) was developed to assess supervision, training, collaborations and experiences of ESRs and forwarded to two tinnitus-related ITNs and seven ITNs of other disciplines. Results: Key advantages identified included better career prospects, multidisciplinary research opportunities/collaborations, international exposure, personal/professional development, plus generous salaries and research budgets. However, lack of a common EU framework resulted in the experience being largely dependent on the host institution, country and supervisor. Moreover, managing the dual requirements of ITNs and host institutions while completing a three-year PhD seemed challenging for most ESRs. ESR involvement in workshop and training school planning was desirable. More than 80% of ESRs rated the overall ITN experience favourably and 98.3% would recommend the same to prospective PhD students. Conclusions: This report could provide valuable insights in planning and management of future ITNs and could assist prospective students in their decision of joining an ITN for their PhD.