bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating associations between COVID-19 mortality and population-level health and socioeconomic indicators in the United States: A modeling study
Authors: Kandula Sasikiran , Shaman Jeffrey 
Published: July 2021

Background
With the availability of multiple Coronavirus Disease 2019 (COVID-19) vaccines and the predicted shortages in supply for the near future, it is necessary to allocate vaccines in a manner that minimizes severe outcomes, particularly deaths. To date, vaccination strategies in the United States have focused on individual characteristics such as age and occupation. Here, we assess the utility of population-level health and socioeconomic indicators as additional criteria for geographical allocation of vaccines.

Methods and findings
County-level estimates of 14 indicators associated with COVID-19 mortality were extracted from public data sources. Effect estimates of the individual indicators were calculated with univariate models. Presence of spatial autocorrelation was established using Moran’s I statistic. Spatial simultaneous autoregressive (SAR) models that account for spatial autocorrelation in response and predictors were used to assess (i) the proportion of variance in county-level COVID-19 mortality that can explained by identified health/socioeconomic indicators (R2); and (ii) effect estimates of each predictor.
Adjusting for case rates, the selected indicators individually explain 24%–29% of the variability in mortality. Prevalence of chronic kidney disease and proportion of population residing in nursing homes have the highest R2. Mortality is estimated to increase by 43 per thousand residents (95% CI: 37–49; p < 0.001) with a 1% increase in the prevalence of chronic kidney disease and by 39 deaths per thousand (95% CI: 34–44; p < 0.001) with 1% increase in population living in nursing homes. SAR models using multiple health/socioeconomic indicators explain 43% of the variability in COVID-19 mortality in US counties, adjusting for case rates. R2 was found to be not sensitive to the choice of SAR model form. Study limitations include the use of mortality rates that are not age standardized, a spatial adjacency matrix that does not capture human flows among counties, and insufficient accounting for interaction among predictors.

Conclusions
Significant spatial autocorrelation exists in COVID-19 mortality in the US, and population health/socioeconomic indicators account for a considerable variability in county-level mortality. In the context of vaccine rollout in the US and globally, national and subnational estimates of burden of disease could inform optimal geographical allocation of vaccines.
A comparison of liver fat fraction measurement on MRI at 3T and 1.5T
Authors: Athithan Lavanya , Gulsin Gaurav S. , House Michael J. , Pang Wenjie , Brady Emer M. , Wormleighton Joanne , Parke Kelly S. , Graham-Brown Matthew , St. Pierre Tim G. , Levelt Eylem , McCann Gerry P. 
Published: July 2021

Purpose
Volumetric liver fat fraction (VLFF) measurements were made using the HepaFat-Scan® technique at 1.5T and 3T to determine the agreement between the measurements obtained at the two fields.

Methods
Sixty patients with type 2 diabetes (67% male, mean age 50.92 ± 6.56yrs) and thirty healthy volunteers (50% male, mean age 48.63 ± 6.32yrs) were scanned on 1.5T Aera and 3T Skyra (Siemens, Erlangen, Germany) MRI scanners on the same day using the HepaFat-Scan® gradient echo protocol with modification of echo times for 3T (TEs 2.38, 4.76, 7.14 ms at 1.5T and 1.2, 2.4, 3.6 ms at 3T). The 3T analyses were performed independently of the 1.5T analyses by a different analyst, blinded from the 1.5T results. Data were analysed for agreement and bias using Bland-Altman methods and intraclass correlation coefficients (ICC). A second cohort of 17 participants underwent interstudy repeatability assessment of VLFF measured by HepaFat-Scan® at 3T.

Results
A small, but statistically significant mean bias of 0.48% was observed between 3T and 1.5T with 95% limits of agreement -2.2% to 3.2% VLFF. The ICC for agreement between field strengths was 0.983 (95% CI 0.972–0.989). In the repeatability cohort studied at 3T the repeatability coefficient was 4.2%. The ICC for agreement was 0.971 (95% CI 0.921–0.989).

Conclusion
There is minimal bias and excellent agreement between the measures of VLFF using the HepaFat-Scan® at 1.5 and 3T. The test retest repeatability coefficient at 3T is comparable to the 95% limits of agreement between 1.5T and 3T suggesting that measurements can be made interchangeably between field strengths.
Cognitive impairment in syphilis: Does treatment based on cerebrospinal fluid analysis improve outcome?
Authors: Davis Arielle P. , Maxwell Clare L. , Mendoza Haley , Crooks Abby , Dunaway Shelia B. , Storey Sher , Stevens Claire , Tantalo Lauren C. , Sahi Sharon K. , Robertson Kevin R. , Marra Christina M. 
Published: July 2021

BackgroundIndividuals with previous syphilis may experience cognitive impairment. The goal of this study was to determine if those at high risk for laboratory-defined neurosyphilis are cognitively impaired, and whether treatment based on cerebrospinal fluid (CSF) findings results in better outcomes.MethodsParticipants had a new syphilis diagnosis, serum RPR titer ≥ 1:32 or peripheral blood CD4+ T cells ≤ 350/ul (in persons living with HIV) and did not endorse neurological symptoms. They underwent computerized cognitive assessment with the CogState. Thirty-two were randomized to either undergo lumbar puncture (LP) or to not undergo LP and 14 underwent LP; 64 were not randomized and 48 opted to undergo LP.ResultsDemographics, cognitive complaints and cognitive impairment did not differ between randomized and nonrandomized participants. Two-thirds were cognitively impaired, and impairment was not more common in those with cognitive complaints. The adjusted odds of increased severity of impairment were 3.8 times greater in those with CSF pleocytosis compared to those without. Time to cognitive normalization, improvement or decline did not differ between those who did not undergo LP and those who underwent LP and whose treatment was based on CSF analysis. Taking into account pre-treatment cognitive impairment, the risk of cognitive decline was lower in those with CSF pleocytosis treated for neurosyphilis compared to those without CSF pleocytosis not treated for neurosyphilis, (HR 0.24 (95% CI 0.07–0.88], p = 0.03).ConclusionIn individuals at high risk for laboratory-defined neurosyphilis, cognitive complaints are not a good indicator of cognitive impairment. Severity of cognitive impairment was greater in those with CSF pleocytosis. Identification and treatment of those with neurosyphilis may mitigate subsequent cognitive decline.
Potential negative impact of reputed regulators’ decisions on the approval status of new cancer drugs in Latin American countries: A descriptive analysis
Authors: Durán Carlos E. , Cañás Martín , Urtasun Martín , Elseviers Monique , Vander Stichele Robert , Christiaens Thierry 
Published: July 2021

Background
Many new cancer drugs are being approved by reputed regulatory authorities without evidence of overall survival benefit, quality of life improvement, and often based on clinical trials at high risk of bias. In recent years, most Latin American (LA) countries have reformed their marketing authorization (MA) rules to directly accept or abbreviate the approval process in case of earlier authorization by the European Medicines Agency (EMA) and the US Food and Drug Administration, mainly. This study assessed the potential impact of decisions taken by EMA regarding the approval of new cancer drugs based on no evidence of overall survival or in potentially biased clinical trials in LA countries.

Design
Descriptive analysis.

Setting
Publicly accessible marketing authorization databases from LA regulators, European Public Assessment Report by EMA, and previous studies accessing EMA approvals of new cancer drugs 2009–2016.

Main outcome and measures
Number of new cancer drugs approved by LA countries without evidence of overall survival (2009–2013), and without at least one clinical trial scored at low risk of bias, or with no trial supporting the marketing authorization at all (2014–2016).

Results
Argentina, Brazil, Chile, Colombia, Ecuador, Panama and Peru have publicly accessible and trustful MA databases and were included. Of the 17 cancer drugs approved by EMA (2009–2013) without evidence of OS benefit after a postmarketing median time of 5.4 years, 6 LA regulators approved more than 70% of them. Of the 13 drugs approved by EMA (2014–2016), either without supporting trial or with no trial at low risk of bias, Brazil approved 11, Chile 10, Peru 10, Argentina 10, Colombia 9, Ecuador 9, and Panama 8.

Conclusions
LA countries keep approving new cancer drugs often based on poorly performed clinical trials measuring surrogate endpoints. EMA and other reputed regulators must be aware that their regulatory decisions might directly influence decisions regarding MA, health budgets and patient’s care elsewhere.
Regional timber supply for shipbuilding and maintenance of war fleets in Cadiz: methods, agents and phases (1717-1736)
Authors: Trindade Ana Rita 
Published: July 2021

In the period of 1717-1736, the southern peninsular forests became a new resource frontier at the service of the Spanish Navy, in the context of the Bourbon Reforms. The timber supply for shipbuilding and maintenance of war fleets in Cádiz was made through four methods: direct administration by commissioned services; purchase from regional middlemen merchants; articulation between contractors and direct administration; articulation with the Royal Exchequer. The rhythm of supply was the reflex of different needs and constraints in three phases: maintenance of fleets during the period of consolidation of Cádiz as a naval and commercial center (1717-1727); the first shipbuilding series (1728-1731); the impact of the 30’s Mediterranean campaigns and the shipbuilding production of Ciprian Autran (1731-1736).
Sensory Adaptation Training or Escitalopram for IBS With Constipation and Rectal Hypersensitivity: A Randomized Controlled Trial
Authors: Rao Satish S.C. , Coss-Adame Enrique , Yan Yun , Erdogan Askin , Valestin Jessica , Ayyala Deepak Nag 
Published: July 2021

INTRODUCTION:
Rectal hypersensitivity is an important pathophysiological dysfunction in irritable bowel syndrome with predominant constipation (IBS-C), whose treatment remains challenging. In a randomized controlled trial, we compared the efficacy and safety of a novel sensori-behavioral treatment, sensory adaptation training (SAT) with escitalopram.

METHODS:
Patients with IBS-C (Rome III) with rectal hypersensitivity received 6 biweekly sessions of SAT or escitalopram 10 mg daily for 3 months. SAT was performed by repetitive gradual distension of 10-cm long highly compliant rectal balloon above tolerability thresholds using barostat. Treatment effects on sensory thresholds and symptoms were compared. Coprimary outcome measures were those achieving improvements in rectal hypersensitivity (≥20% increase in ≥2/3 sensory thresholds) and pain (≥30% decrease).

RESULTS:
We randomized 49 patients; 26 received SAT and 23 escitalopram. SAT significantly improved desire to defecate (Δ 13.5 ± 2.3 vs 2.2 ± 1.1 mm Hg, P = 0.0006) and maximum tolerability (Δ 14.8 ± 1.9 vs 1.6 ± 0.9 mm Hg, P < 0.0001) thresholds compared with escitalopram. There were significantly greater percentage of hypersensitivity responders with SAT than escitalopram (69% vs 17%, P < 0.001), but not pain responders (58% vs 44%, P = 0.4). Daily pain scores did not differ between groups (P = 0.8) or escitalopram (P = 0.06) but decreased with SAT (P = 0.0046) compared with baseline. SAT significantly increased rectal compliance (P < 0.019) and complete spontaneous bowel movements per week than escitalopram (P = 0.04). Five withdrew from adverse events with escitalopram and none with SAT.

DISCUSSION:
SAT was significantly more efficacious in improving hypersensitivity and bowel symptoms in IBS-C than escitalopram. SAT is a promising novel treatment for IBS with rectal hypersensitivity.
The effect on student behaviour and achievement of removing incentives to complete online formative assessments
Authors: Agnew Stephen , Kerr Jane , Watt Richard 
Published: July 2021

This research explored the effect of incentives to complete online quizzes during a course. When a 1% weighting incentive per quiz was removed, student engagement dropped dramatically. There is also evidence that students who continued to complete quizzes did so with less vigour, spending less time on each quiz, starting them later in the week and having fewer attempts per quiz on average. The average mark per quiz was also lower once an incentive to complete them was removed. There was no significant difference in examination performance based on how many quizzes a student continued to attempt after incentives were removed. However, a comparison to a control group of students who sat the same invigilated assessments showed that, relative to term test performance, final exam mean score was 7% lower for the cohort who had the incentive to complete online quizzes removed. This differed from the control group, who showed no difference between term test and final examination mean scores when quiz incentives were maintained for the entire course. Building on previous research, this study demonstrates that a binary variable representing engagement in online quizzes did not capture the quality of that online engagement.
Implications for practice or policy:

Completion of online formative assessments by students is reduced if course leaders remove small-stakes incentives.
The removal of small-stakes incentives by course leaders harms student motivation and achievement. Specifically, students who complete formative online assessment without incentives have fewer attempts, start them later in the availability window, spend less time completing them and record a lower mean score than those with incentives.
Average final examination achievement is lower when incentives to complete online formative assessments are removed by course leaders.
Corona an der Universitätsbibliothek Basel: Die zwei Seiten der Digitalisierungsmedaille
Authors: Tréfás David 
Published: July 2021

Zusammenfassung
Die Maßnahmen, die in der Schweiz landesweit zur Bewältigung der Corona-Pandemie eingeführt wurden, betrafen auch die Universitätsbibliothek Basel. Auf den ersten Schock folgte während der ersten Welle eine regelrechte Digitalisierungseuphorie, die während der zweiten Welle einer Digitalisierungsmüdigkeit wich. In einer Erholungsphase im Sommer 2020 wurden die Mitarbeitenden über ihre Erfahrungen befragt, Lehren gezogen und Maßnahmen beschlossen. Es zeigte sich vor allem, dass die Bewältigung einer Krise vor allem nach guter Führung verlangt.
Wissenschaftliche Weiterbildung während und nach der COVID-19-Pandemie – der Versuch einer theoretischen Annäherung
Authors: Georgy Ursula 
Published: July 2021

Zusammenfassung
Die wissenschaftliche Weiterbildung hat sich durch die COVID-19-Pandemie grundlegend verändert. Dies betrifft zum einen die Formate, aber auch die Zielgruppen und vor allem die Anforderungen in der Zukunft. Für das ZBIW und auch für andere Weiterbildungsanbieter stellt dies in den meisten Fällen eine große Herausforderung dar. Der Beitrag stellt die Veränderungen in einen theoretischen Kontext, um herauszustellen, wie wichtig strategisches Vorgehen ist, um erfolgreich durch eine Krise zu kommen.
Wenn das Leben Dir Zitronen gibt … Pandemie als Chance?
Authors: Bodem Claudia , Ellis Rachel , Kabitzke Katrin 
Published: July 2021

Zusammenfassung
Wie alle anderen Bibliotheken stand auch die SuUB am Anfang der Pandemie von einem Tag auf den anderen vor zahlreichen neuen Herausforderungen. Entscheidungen mussten innerhalb kürzester Zeit gefällt und Angebote kurzfristig angepasst werden. Die Auswirkungen der Pandemie betrafen und betreffen alle Bereiche der Bibliothek. Der Fokus dieses Beitrags liegt jedoch auf den Kundenservices und der internen Zusammenarbeit. Die Ausführungen beschränken sich auf den größten Standort, die Zentrale auf dem Campus der Universität Bremen.
Effect of yoga on cardiovascular functions and psychological aspects of people on public service-related work: an exploratory study
Authors: Deepa Y. , Mooventhan A. , Christa Edmin , Kayelarasi C.A. 
Published: July 2021

Abstract

Objectives
Yoga is increasingly being introduced in workplace settings to improve health and well-being. However, there is a lack of studies reporting the effect of yoga in people on public service-related work, who are at high risk for various health-related problems. Thus, the objective of this study was to find the effect of yoga on cardiovascular functions and psychological (stress, anxiety, and depression) aspects of people on public service-related work.

Methods
A single-group pre-test and post-test experimental study design was adopted. Eighty-two participants aged 41.52 ± 7.44 years who are working in the Tamil Nadu Public Service Commission were undergone 1-h of yoga (under the supervision of a yoga & naturopathy doctor) a day, 5-days a week for a period of 1-month at their office. Cardiovascular functions such as systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) were measured using an automatic BP monitor. Psychological variables such as stress, anxiety, and depression were measured using Depression Anxiety and Stress Scales (DASS) before and after the intervention.

Results
Results of this study showed a significant reduction in body mass index, SBP, DBP, PR, mean arterial pressure, rate pressure product, and double product. Though results showed insignificant (just missed the statistical significance [p=0.056]) reduction in anxiety, it showed clinical improvement (i.e. the mean anxiety score has reduced from moderate category to mild category). However, there is neither statistically significant nor clinical difference in stress and depression. None of the participants reported any untoward events during the study period.

Conclusions
Results suggest that yoga might improve the cardiovascular functions and anxiety of people in public service-related work. However, no such significant improvement was noted in their stress and depression levels. However, a randomized controlled trial is required to warrant the results of this study.
An optimization of color halftone visual cryptography scheme based on Bat algorithm
Authors: Aswad Firas Mohammed , Salman Ihsan , Mostafa Salama A. 
Published: July 2021

AbstractVisual cryptography is a cryptographic technique that allows visual information to be encrypted so that the human optical system can perform the decryption without any cryptographic computation. The halftone visual cryptography scheme (HVCS) is a type of visual cryptography (VC) that encodes the secret image into halftone images to produce secure and meaningful shares. However, the HVC scheme has many unsolved problems, such as pixel expansion, low contrast, cross-interference problem, and difficulty in managing share images. This article aims to enhance the visual quality and avoid the problems of cross-interference and pixel expansion of the share images. It introduces a novel optimization of color halftone visual cryptography (OCHVC) scheme by using two proposed techniques: hash codebook and construction techniques. The new techniques distribute the information pixels of a secret image into a halftone cover image randomly based on a bat optimization algorithm. The results show that these techniques have enhanced security levels and make the proposed OCHVC scheme more robust against different attacks. The OCHVC scheme achieves mean squared error (MSE) of 95.0%, peak signal-to-noise ratio (PSNR) of 28.3%, normalized cross correlation (NCC) of 99.4%, and universal quality index (UQI) of 99.3% on average for the six shares. Subsequently, the experiment results based on image quality metrics show improvement in size, visual quality, and security for retrieved secret images and meaningful share images of the OCHVC scheme. Comparing the proposed OCHVC with some related works shows that the OCHVC scheme is more effective and secure.
The Ahmadiyya, Blasphemy and Religious Freedom: The Institutional Discourse Analysis of Religious Discrimination in Indonesia
Authors: Irawan Andi Muhammad , Adnan Zifirdaus 
Published: July 2021

AbstractThe article investigates the development of discourses related to freedom of religion and discrimination against religious minority in current Indonesia by identifying the discourse constructions of Ahmadiyya in various texts and talks produced and disseminated by government institution and the Indonesian Council of Ulama (the MUI). This study aims to reveal these institutions’ views and perspectives on Ahmadiyya issue using various discourse strategies. The data analysed are some legal proclamations issued and personal views delivered by the officials of these two institutions. The CDA theoretical framework employed is to examine the positive-self and negative-other presentations. The finding reveals that the issue of Ahmadiyya is addressed through discourses related to Indonesian national interest and discourses related to religious matters. in these discourses, the two institutions and their officials present themselves positively and portray the Ahmadiyya sect negatively. The sect followers are negatively presented as the troublemaker, blasphemer, and the destroyer of religious harmony and social order.
What can women’s networks do to close the gender gap in STEM?
Authors: Kim Jung Sun 
Published: July 2021

Abstract
Despite the efforts of the Korean government to implement gender mainstreaming in Science, Technology, Engineering and Mathematics (STEM), the gender gap remains intact. The low rank of Gender Gap Indices (GGI) of Korea is mainly due to the low economic participation of women, especially in STEM. However, Korea has been steadily advancing in terms of government policies for women in STEM. The enactment of the law on fostering and supporting women in science and technology in 2002 is attributed to the collective efforts of women scientists and engineers through a women in STEM organization. The next task for women’s networks would be to identify the barriers of gender disparities by gathering the voices of women in STEM.
TOTAD interface: A review of its application for LVI and LC-GC
Authors: Espinosa Francisco J. , Toledano Rosa M. , Villén Jesús , Cortés Jose M. , Vázquez Ana M. 
Published: July 2021

Abstract
Large volume injection (LVI) in gas chromatography (GC) and online liquid chromatography-gas chromatography (LC-GC) are useful techniques for analyzing the compounds present at very low concentrations in complex samples since they substantially increase the sensitivity of the analysis and simplify sample preparation. LVI avoids the need to concentrate the extract and even the extraction step itself by directly injecting the sample. In online LC-GC, the liquid chromatography (LC) step acts as the sample preparation and/or fractionation step. The main problem in both techniques is the selective elimination of the large volume of solvent without losing the analytes. The TOTAD (through oven transfer adsorption–desorption) interface, based on a widely modified PTV (programmed temperature vaporizer) injector, allows large volumes to be injected into the gas chromatograph using both nonpolar and polar solvents, including water. Consequently, online LC-GC can be carried out whether the LC step is in the normal phase or the reversed phase. Various methods for analyzing trace compounds in food and environmental samples have been developed for LVI and online LC-GC using the TOTAD interface. Such analysis methods require the optimization of several variables common to LVI and online LC-GC and specific variables involved in online LC-GC, which must be optimized by taking into account the nature of the analytes and the characteristics of the sample matrix. This article reviews how each of these variables affects the performance of the analysis.