bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry
Authors: Satterfield Benjamin A. , Dikilitas Ozan , Safarova Maya S. , Clarke Shoa L. , Tcheandjieu Catherine , Zhu Xiang , Bastarache Lisa , Larson Eric B. , Justice Anne E. , Shang Ning , Rosenthal Elisabeth A. , Shah Amy Sanghavi , Namjou-Khales Bahram , Urbina Elaine M. , Wei Wei-Qi , Feng QiPing , Jarvik Gail P. , Hebbring Scott J. , de Andrade Mariza , Manolio Teri A. , Assimes Themistocles L. , Kullo Iftikhar J. 
Published: July 2021

Background:
Lp(a) (lipoprotein [a]) levels are higher in individuals of African ancestry (AA) than in individuals of European ancestry (EA). We examined associations of genetically predicted Lp(a) levels with (1) atherosclerotic cardiovascular disease subtypes: coronary heart disease, cerebrovascular disease, peripheral artery disease, and abdominal aortic aneurysm and (2) nonatherosclerotic cardiovascular disease phenotypes, stratified by ancestry.

Methods:
We performed (1) Mendelian randomization analyses for previously reported cardiovascular associations and (2) Mendelian randomization–phenome-wide association analyses for novel associations. Analyses were stratified by ancestry in electronic Medical Records and Genomics, United Kingdom Biobank, and Million Veteran Program cohorts separately and in a combined cohort of 804 507 EA and 103 580 AA participants.

Results:
In Mendelian randomization analyses using the combined cohort, a 1-SD genetic increase in Lp(a) level was associated with atherosclerotic cardiovascular disease subtypes in EA—odds ratio and 95% CI for coronary heart disease 1.28 (1.16–1.41); cerebrovascular disease 1.14 (1.07–1.21); peripheral artery disease 1.22 (1.11–1.34); abdominal aortic aneurysm 1.28 (1.17–1.40); in AA, the effect estimate was lower than in EA and nonsignificant for coronary heart disease 1.11 (0.99–1.24) and cerebrovascular disease 1.06 (0.99–1.14) but similar for peripheral artery disease 1.16 (1.01–1.33) and abdominal aortic aneurysm 1.34 (1.11–1.62). In EA, a 1-SD genetic increase in Lp(a) level was associated with aortic valve disorders 1.34 (1.10–1.62), mitral valve disorders 1.18 (1.09–1.27), congestive heart failure 1.12 (1.05–1.19), and chronic kidney disease 1.07 (1.01–1.14). In AA, no significant associations were noted for aortic valve disorders 1.08 (0.94–1.25), mitral valve disorders 1.02 (0.89–1.16), congestive heart failure 1.02 (0.95–1.10), or chronic kidney disease 1.05 (0.99–1.12). Mendelian randomization–phenome-wide association analyses identified novel associations in EA with arterial thromboembolic disease, nonaortic aneurysmal disease, atrial fibrillation, cardiac conduction disorders, and hypertension.

Conclusions:
Many cardiovascular associations of genetically increased Lp(a) that were significant in EA were not significant in AA. Lp(a) was associated with atherosclerotic cardiovascular disease in four major arterial beds in EA but only with peripheral artery disease and abdominal aortic aneurysm in AA. Additionally, novel cardiovascular associations were detected in EA.
Translating Functional Connectivity After Stroke: Functional Magnetic Resonance Imaging Detects Comparable Network Changes in Mice and Humans
Authors: Blaschke Stefan J. , Hensel Lukas , Minassian Anuka , Vlachakis Susan , Tscherpel Caroline , Vay Sabine U. , Rabenstein Monika , Schroeter Michael , Fink Gereon R. , Hoehn Mathias , Grefkes Christian , Rueger Maria A. 
Published: July 2021

Background and Purpose:
The translational roadblock has long impeded the implementation of experimental therapeutic approaches for stroke into clinical routine. Considerable interspecies differences, for example, in brain anatomy and function, render comparisons between rodents and humans tricky, especially concerning brain reorganization and recovery of function. We tested whether stroke-evoked changes in neural networks follow similar patterns in mice and patients using a systems-level perspective.

Methods:
We acquired resting-state functional magnetic resonance imaging data during the early poststroke phase in a sample of human patients and compared the observed network changes with data from 2 mouse stroke models, that is, photothrombosis and distal middle cerebral artery occlusion. Importantly, data were subjected to the same processing steps, allowing a direct comparison of global network changes using graph theory.

Results:
We found that network parameters computed for both mouse models of stroke and humans follow a similar pattern in the postacute stroke phase. Parameters indicating the global communication structure’s facilitation, such as small worldness and characteristic path length, were similarly changed in humans and mice in the first days after stroke. Additionally, small worldness correlated with concurrent motor impairment in humans. Longitudinal observation in the subacute phase revealed a negative correlation between initial small worldness and motor recovery in mice.

Conclusions:
We show that network measures based on resting-state functional magnetic resonance imaging data after stroke obtained in mice and humans share notable features. The observed network alterations could serve as therapeutic readout parameters for future translational studies in stroke research.
Residual Inflammatory Risk Predicts Poor Prognosis in Acute Ischemic Stroke or Transient Ischemic Attack Patients
Authors: Li Jiejie , Pan Yuesong , Xu Jie , Li Shiyu , Wang Mengxing , Quan Kehua , Meng Xia , Li Hao , Lin Jinxi , Wang Yilong , Zhao Xingquan , Liu Liping , Wang Yongjun ,   on behalf of the CNSR-III Investigators
Published: July 2021

Background and Purpose:
It is still unclear whether the residual cholesterol and inflammatory risk in the acute phase is associated with prognosis of stroke. We aimed to investigate the proportion and relative contribution of residual cholesterol and inflammatory risk, determined by baseline low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) levels, to the risk of recurrent stroke and poor functional outcome at 1 year.

Methods:
In this prospective multicenter cohort study, 10 499 consecutive acute ischemic stroke and transient ischemic attack patients with levels of LDL-C and hsCRP were enrolled. Patients were divided into 4 groups: residual cholesterol risk only (LDL-C ≥2.6 mmol/L and hsCRP <3 mg/L), residual inflammatory risk (RIR) only (LDL-C <2.6 mmol/L and hsCRP ≥3 mg/L), both risk (LDL-C ≥2.6 mmol/L and hsCRP ≥3 mg/L), and neither risk (LDL-C <2.6 mmol/L and hsCRP <3 mg/L). The primary outcomes consisted of stroke recurrence and a modified Rankin Scale score of 2 to 6 within 1 year.

Results:

The relative proportions of patients with RIR only, residual cholesterol risk only, both risk, and neither were 21.3%, 23.7%, 14.4%, and 40.6%, respectively. RIR only was independently associated with recurrent stroke (adjusted hazard ratio, 1.18 [95% CI, 1.00–1.40];
P
=0.05). The association was slightly attenuated after further adjusting for usage of antiplatelet agent and statin during 1-year follow-up in addition to the traditional risk factors (hazard ratio, 1.31 [95% CI, 0.99–1.76];
P
=0.07). When applying the LDL-C cutoff value of 1.8 mmol/L in the sensitivity analyses, such association in large-artery atherosclerosis subtype was more significant (adjusted hazard ratio, 1.69 [95% CI, 1.06–2.67];
P
=0.03). Patients with RIR only also had increased risk of poor functional outcome (adjusted odds ratio, 1.43 [95% CI, 1.24–1.64];
P
<0.0001).

Conclusions:
In the patients with acute ischemic stroke or transient ischemic attack, RIR only could be predictive for recurrent stroke, especially for those with large-artery atherosclerosis, and poor functional outcome.
Association of Oral Anticoagulation With Stroke in Atrial Fibrillation or Heart Failure
Authors: Reddin Catriona , Judge Conor , Loughlin Elaine , Murphy Robert , Costello Maria , Alvarez Alberto , Ferguson John , Smyth Andrew , Canavan Michelle , O’Donnell Martin J. 
Published: July 2021

Background and Purpose:
Atrial fibrillation and heart failure with reduced ejection fraction (HFrEF) are common sources of cardioembolism. While oral anticoagulation is strongly recommended for atrial fibrillation, there are marked variations in guideline recommendations for HFrEF due to uncertainty about net clinical benefit. This systematic review and meta-analysis evaluates the comparative association of oral anticoagulation with stroke and other cardiovascular risk in populations with atrial fibrillation or HFrEF in sinus rhythm and identify factors mediating different estimates of net clinical benefit.

Methods:

PubMed and Embase were searched from database inception to November 20, 2019 for randomized clinical trials comparing oral anticoagulation to control. A random-effects meta-analysis was used to estimate a pooled treatment-effect overall and within atrial fibrillation and HFrEF trials. Differences in treatment effect were assessed by estimating I
2
among all trials and testing the between-trial-population
P
-interaction. The primary outcome measure was all stroke. Secondary outcome measures were ischemic stroke, hemorrhagic stroke, mortality, myocardial infarction, and major hemorrhage.

Results:

Twenty-one trials were eligible for inclusion, 15 (n=19 332) in atrial fibrillation (mean follow-up: 23.1 months), and 6 (n=9866) in HFrEF (mean follow-up: 23.9 months). There were differences in primary outcomes between trial populations, with all-cause mortality included for 95.2% of HFrEF trial population versus 0.38% for atrial fibrillation. Mortality was higher in controls groups of HFrEF populations (19.0% versus 9.6%) but rates of stroke lower (3.1% versus 7.0%) compared with atrial fibrillation. The association of oral anticoagulation with all stroke was consistent for atrial fibrillation (odds ratio, 0.51 [95% CI, 0.42–0.63]) and HFrEF (odds ratio, 0.61 [95% CI, 0.47–0.79]; I
2
=12.4%;
P
interaction=0.31). There were no statistically significant differences in the association of oral anticoagulation with cardiovascular events, mortality or bleeding between populations.

Conclusions:
The relative association of oral anticoagulation with stroke risk, and other cardiovascular outcomes, is similar for patients with atrial fibrillation and HFrEF. Differences in the primary outcomes employed by trials in HFrEF, compared with atrial fibrillation, may have contributed to differing conclusions of the relative efficacy of oral anticoagulation.
Factors Responsible for the Increase of Winter Low Temperature Extremes from the Mid-1990s to the Early 2010s in Northern China
Authors: Wang Zunya , Liu Yanju , Wang Guofu , Zhang Qiang 
Published: July 2021

AbstractIt is argued that the occurrence of cold events decreases under the background of global warming. However, from the mid-1990s to the early 2010s, northern China experienced a period of increasing occurrence of low temperature extremes (LTE). Factors responsible for this increase of LTE are investigated in this analysis. The results show that the interdecadal variation of the winter mean temperature over mid- and high-latitude Eurasia acts as an important thermal background. It is characterized by two dominant modes, the “consistent cooling” pattern and the “warm high-latitude Eurasia and cold midlatitude Eurasia” pattern, from the mid-1990s to the early 2010s. The two patterns jointly provide a cooling background for the increase of LTE in northern China. Meanwhile, though the interdecadal variation of the Arctic Oscillation (AO), Ural blocking (UB), and Siberian high (SH) are all highly correlated with the occurrence of LTE in northern China, the AO is found to play a dominant role. On one hand, the AO directly affects the occurrence of LTE because of its dynamic structure; on the other hand, it takes an indirect effect by affecting the intensity of UB and SH. Further analyses show that the winter temperature in mid- and high-latitude Eurasia and the AO are independent factors that influence the increase of LTE in northern China from the mid-1990s to the early 2010s.
Projections of South Asian Summer Monsoon Under Global Warming from 1.5° to 5°C
Authors: Li Zhibo , Sun Ying , Li Tim , Chen Wen , Ding Yihui 
Published: July 2021

AbstractThe South Asian summer monsoon (SASM) is one of the most crucial climate components in boreal summer. The future potential changes in the SASM have great importance for climate change adaption and policy setting in this populous region. To understand the SASM changes and its link with the global warming of 1.5°C to 5°C above the preindustrial level, we investigate the changes in the SASM circulation and precipitation based on a large-ensemble simulation conducted with Canadian Earth System Model version 2 (CanESM2). With the global mean surface temperature (GMST) increase, the large-ensemble mean of SASM circulation is projected to weaken almost linearly while the precipitation and precipitable water to enhance quasi-linearly. A double anticyclone along the tropical Indian Ocean is a major anomalous circulation pattern for each additional degree of warming and is responsible for the weakening of the lower-level westerlies. The decreased upper-level land-sea thermal contrast (TCupper) is the main thermal driver for the weakening of the SASM circulation while the lower-level thermal contrast contributes little. The non-linearly decreased TCupper is mainly related to the temperature response to the increased CO2 forcing and convection induced latent heat release in the tropics. The increase in the SASM precipitation is mainly due to the quasi-linearly increased positive contribution of the thermodynamic component, while the dynamic component has a negative impact. Both horizontal moisture advection and moisture convergence contribute to the precipitation increase, and moisture convergence plays a dominant role. These results provide new insight that the SASM changes can be roughly scaled by the GMST changes.
The annual cycle of terrestrial water storage anomalies in CMIP6 models evaluated against GRACE data
Authors: Wu Ren-Jie , Lo Min-Hui , Scanlon Bridget R. 
Published: July 2021

AbstractTerrestrial water storage anomaly (TWSA) is a critical component of the global water cycle where improved spatiotemporal dynamics would enhance exploration of weather and climate-linked processes. Thus, correctly simulating TWSA is essential not only for water-resource management but also for assessing feedbacks to climate through land-atmosphere interactions. Here we evaluate simulated TWSA from 25 climate models (from the Climate Model Intercomparison Project 6) through comparison with TWSA from GRACE satellite data (2003 – 2014) in 14 river basins globally and assess causes of discrepancies by examining precipitation (P), evapotranspiration (ET), and runoff (Roff) fluxes during recharge (increasing TWS) and discharge (decreasing TWS) cycles. Most models show consistent biases in seasonal amplitudes of TWS anomalies relative to GRACE output: higher modeled amplitudes in river basins in high northern latitudes, Parana, and Congo, and lower amplitudes in most mid-latitude basins and other tropical basins. This TWSA systematic bias also exists in the previous CMIP5 simulations. Models overestimate P compared to observed P datasets in 7 out of 14 basins, which increases (decreases) seasonal storage amplitude relative to GRACE in the recharge (discharge) cycle. Overestimation (underestimation) of runoff is another common contributing factor in the discharge phase that increases (decreases) TWSA amplitudes relative to GRACE in 5 river basins. The results provide a comprehensive assessment of the reliability of the simulated annual range in TWSA through comparison with GRACE data that can be used to guide future model development.
Retrieval of Snow Water Equivalent by the Precipitation Imaging Package (PIP) in the Northern Great Lakes
Authors: Tokay Ali , Lerber Annakaisa von , Pettersen Claire , Kulie Mark S. , Moisseev Dmitri N. , Wolff David B. 
Published: July 2021

Abstract
Performance of the Precipitation Imaging Package (PIP) for estimating the snow water equivalent (SWE) is evaluated through a comparative study with the collocated National Oceanic and Atmospheric Administration National Weather Service snow stake field measurements. The PIP together with a vertically pointing radar, a weighing bucket gauge, and a laser-optical disdrometer was deployed at the NWS Marquette, Michigan, office building for a long-term field study supported by the National Aeronautics and Space Administration’s Global Precipitation Measurement mission Ground Validation program. The site was also equipped with a weather station. During the 2017/18 winter, the PIP functioned nearly uninterrupted at frigid temperatures accumulating 2345.8 mm of geometric snow depth over a total of 499 h. This long record consists of 30 events, and the PIP-retrieved and snow stake field measured SWE differed less than 15% in every event. Two of the major events with the longest duration and the highest accumulation are examined in detail. The particle mass with a given diameter was much lower during a shallow, colder, uniform lake-effect event than in the deep, less cold, and variable synoptic event. This study demonstrated that the PIP is a robust instrument for operational use, and is reliable for deriving the bulk properties of falling snow.
Characteristics and treatment outcome of suicidal depression: Two large naturalistic cohorts of depressed outpatients
Authors: Nobile Bénédicte , Olié Emilie , Dubois Jonathan , Guillaume Sebastien , Gorwood Philip , Courtet Philippe 
Published: July 2021

Objective: The emergence of new drugs for managing suicidal ideation (e.g. ketamine) raises the question of whether suicidal depression (i.e. moderate to severe depression with concomitant suicidal ideation) is a specific depression phenotype. Therefore, this study characterized patients with suicidal depression (baseline clinical characteristics, suicidal ideation and depression evolutions, suicide risk) in two large cohorts of outpatients with depression. Methods: LUEUR and GENESE are two large, prospective, naturalistic cohorts of French adult outpatients with depression (Diagnostic and Statistical Manual of Mental Disorders, fourth edition, criteria), treated and followed up for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale, and suicidal ideation with the suicidal item of the Montgomery–Åsberg Depression Rating Scale. Patients with moderate or severe depression (Hospital Anxiety and Depression Scale–Depression subscale score >11) were selected and classified as without suicidal ideation (suicidal item of the Montgomery–Åsberg Depression Rating Scale <2), with moderate suicidal ideation (suicidal item of the Montgomery–Åsberg Depression Rating Scale [2; 3]) and with severe suicidal ideation (suicidal item of the Montgomery–Åsberg Depression Rating Scale ⩾4). Results: Baseline clinical features were more severe (e.g. higher anxiety and depression scores) in depressed patients with moderate/severe suicidal ideation. Depression remission after treatment was less frequent among patients with severe suicidal ideation. The risk of suicide attempt during the follow-up was threefold higher in patients with suicidal ideation among those 10% had persistent suicidal ideation. Conclusion: Suicidal depression could be a specific depression phenotype with more severe clinical characteristics, less frequent depression remission, suicidal ideation persistence and higher suicide attempt risk, despite antidepressant treatment. It seems that novel therapeutic strategies could be needed.
Loneliness Among US Adults Aged ≥55 Early in the COVID-19 Pandemic
Authors: O’Shea Brendan Q. , Finlay Jessica M. , Kler Jasdeep , Joseph Carly A. , Kobayashi Lindsay C. 
Published: July 2021

Objectives Loneliness is associated with increased risks of adverse health outcomes among middle-aged and older adults. We estimated the prevalence of loneliness and identified key sociodemographic, employment, living, and health-related risk factors for loneliness among adults aged ≥55 during the early phase of the COVID-19 pandemic in the United States, when much of the country was under shelter-in-place orders. Methods We collected data from online questionnaires in the COVID-19 Coping Study, a national study of 6938 US adults aged ≥55 from April 2 through May 31, 2020. We estimated the population-weighted prevalence of loneliness (scores ≥6 of 9 on the 3-item UCLA Loneliness Scale), overall and by sociodemographic, employment, living, and health-related factors. We used population-weighted modified Poisson regression models to estimate prevalence ratios (PRs) and 95% CIs for the associations between these factors and loneliness, adjusting for age, sex, race, ethnicity, and education level. Results Overall, we estimated that 29.5% (95% CI, 27.9%31.3%) of US adults aged ≥55 were considered high in loneliness in April and May 2020. In population-weighted adjusted models, loneliness was the most prevalent among those who reported depression, who were not married or in a relationship, who lived alone, and who were unemployed at the onset of the pandemic. Conclusions We identified subpopulations of middle-aged and older adults who were vulnerable to loneliness during a period when COVID-19 shelter-in-place orders were in place across most of the country. These insights may inform the allocation of resources to mitigate an unintended health consequence during times of restricted activity.
The Importance of Female Mentors and Safety in the Workplace to Female Otolaryngology Applicants When Creating Rank Lists
Authors: Goosmann Madeline , Williams Amy M. , Grewal Jeewanjot , Patel Jena , Jones Lamont , Yaremchuk Kathleen L. 
Published: July 2021

Objectives: The aim of this research is to understand the importance of female career mentors, research mentors, co-residents, and program directors/chairs to current female otolaryngology residents when applying to residency. The importance of safety in the workplace was also investigated. Methods: Surveys were sent via electronic mail to 119 programs, and program directors were asked to distribute them to female residents. Using the Likert scale, participants ranked the importance of various factors when creating a rank list, in particular, importance of safety in the workplace and importance of female mentors in various leadership positions. Demographic information, geographic location, LGBTQ identification, and fellowship plans were also collected. Results: There were 62 participants nationally. Eighty-seven percent (n = 54) of participants stated that having at least 1 female attending and having female co-residents was “very important” or “important” when ranking programs. A number of respondents replied that having a female career development mentor (38.7% [n = 24] and 43.5% [n = 27]), female program director or chair (4.8% [n = 3] and 16.1% [n = 10]), and female research mentor (12.9% [n = 8] and 29% [n = 18]) was “very important” or “important,” respectively. Ninety-three percent (n = 58) replied that feeling safe in their training environment was “very important” or “important.” Conclusion: Having female mentors as well as safety in the workplace in residency is important to a vast majority of residents and applicants when creating a rank list. Programs with women in these roles may gain a disproportionate number of female residents because they may be more desirable places than those without women in these roles.