bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of Neutrophil to Lymphocyte ratio and platelet to lymphocyte ratio as early predicter of severe acute biliary pancreatitis
Authors: Shah Surendra , Paudyal Sanjaya , Maharjan Shanta Bir , Shah Shailendra , Shah Jay Narayan 
Published: July 2021

Introduction: Acute severe pancreatitis is associated with increased mortality. Several scoring systems have been used to predict severe acute pancreatitis which are either time-consuming or calculated 48 hours after admission. This study was aimed to assess the utility of neutrophils to lymphocyte ratio and platelet to lymphocyte ratio as an early predictor of severe acute biliary pancreatitis.Materials and Methods: This was a retrospective cohort study conducted from January 2017 to January 2020. Patients with non-biliary pancreatitis, referred after initial treatment, missed data, and acute pancreatitis with acute cholecystitis or cholangitis were excluded from the study. Data were collected from case sheets. Patients were divided into two groups according to the development of severe acute biliary pancreatitis based on the revised Atlanta Classification. Association of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with severe acute biliary pancreatitis was assessed using Mann Whitney U-test. p-value < 0.05 was considered as statistically significant.Results: Total 73 cases included in the study (males/females= 0.55). Sixty-six patients (90.4%) had mild/moderate acute biliary pancreatitis, and 7 (9.6%) patients had severe acute biliary pancreatitis. There was a development of complications in 7 (9.6%) patients who had severe acute biliary pancreatitis including one mortality. The mean neutrophil to lymphocyte ratio and mean platelet to lymphocyte ratio were high in the severe acute biliary pancreatitis group compared to the nonsevere acute biliary pancreatitis group, however, these differences were not statistically significant.Conclusions: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio cannot predict severe acute biliary pancreatitis.
Diet Pattern and Dyslipidemia Among Type II Diabetes Mellitus Patients Diagnosed More Tthan One Year Visiting Tribhuvan University Teaching Hospital
Authors: Niroula Samiksha , Subba Rama , Karkee Aarem 
Published: July 2021

Introduction: Dyslipidemia is a risk factor for coronary artery disease, a leading cause of mortality in patients with type 2 diabetes mellitus. This study aims to study the dietary pattern and dyslipidemia of type 2 diabetes mellitus patients visiting Tribhuvan University Teaching Hospital.
Materials and Methods: Quantitative study was done to find out the dietary pattern and dyslipidemia of type 2 diabetes mellitus patients visiting Tribhuvan University Teaching Hospital. Patients with type 2 diabetes mellitus diagnosed for more than one year were included in the study.
Results: The percentage of dyslipidemia in type 2 diabetes mellitus was found to be 88.5%. Dyslipidemia was found to be significantly associated (p<0.05) with alcohol consumption, regular dietary management, sedentary behavior, waist-hip ratio, body mass index, glycated hemoglobin, and hypertension. Dyslipidemia was also found to be significantly associated (p<0.05) with the dietary habit (vegetarian and non-vegetarian), consumption of cereals and its product, consumption of fruits, consumption of fast foods and street foods, consumption of red meat, and consumption of oilseeds.
Conclusions: This study indicates the importance of dietary awareness and lifestyle modification for the management of dyslipidemia among type 2 diabetes mellitus.
Unexplained Fatigue in an Otherwise Healthy Man Linked to Kikuchi-Fujimoto Disease, A Case Report
Authors: Pant Vivek , Pradhan Santosh , Sharma Vijay Kumar 
Published: July 2021

Kikuchi histiocytic necrotizing lymphadenitis is a benign and self-limited illness usually characterized by cervical lymphadenopathy and fever. We present a case of a 42-year male who complained of extreme fatigue for 2 weeks. On laboratory workup, he had leucopenia and thrombocytopenia with normal peripheral blood and bone marrow examination. The radiological investigation revealed multiple enlarged lymph nodes in the left axilla and left supraclavicular region. The subsequent excisional biopsy of the axillary node clinched the diagnosis of Kikuchi- Fujimoto disease. The patient was completely recovered and laboratory parameters were normal with supportive treatment. Kikuchi- Fujimoto disease should be considered in patients with unexplained fatigue with lymphadenopathy and early biopsy prevents unnecessary investigations as well as potentially harmful treatments.
Artistic reconstruction of the folklore text in the works of Yu. Illienko (on the example of a film-apologue “A well for the thirsty ones”)
Authors: Breslavets G. 
Published: July 2021

The topicality. The factors that influence the disclosure nature of the director’s and composer’s creative concept are the leading artistic polystylistic tendencies — stylistic layers and trailblazing experiments in the formation of sound-timbre and visualized combinations, where ancient intonations together with modern sound formation and video performance create new sound and performance realities.
The purpose. To determine the role of artistic reconstruction of the folklore text and the specifics of their artistic embodiment in the film parable “A well for the thirsty ones” by the popular Ukrainian film director Yu. Illienko; to determine the specifics of the embodiment of the signs of cultural codes in the musical-sound score of the film by composer L. Hrabovskyi.
The methodology. The culturological approach applied in revealing the issues of the article made it possible to consider the peculiarities of the drama and musical-sound score of Yu. Illienko’s film “A well for the thirsty ones” in a broad cultural context. The interpretive approach helped to highlight the importance of cultural codes of the folklore text, the specifics of their embodiment in the director’s idea through the artistic reconstruction of the folklore text.
The results. Yu. Illienko and L. Hrabovskyi, addressing the folk song tradition, create a new intonation world, embodied in separate “emergings” of female solo singing (verses of the ballad one by one are strung like beads throughout the picture), in lamentations, in incantations, in children’s amusements when playing on pots, that intersperse with a general, very concise and minimalist sound score of the film. The characteristic and figural semantics of the musical-sound background of the film is saturated with active rhythmics, complex sound palette of combination of electronic sounds with natural ones, which demonstrates the author’s (at the choice of director and composer) special sound complex. Folklore texts in the film create a single hypertext, which is manifested at the appropriate levels — auditory, visual and dramatic.
The novelty. The article considers for the first time the specifics of the embodiment of artistic reconstruction of a folklore text as the basis of the drama of Yu. Illienko’s film “A well for the thirsty ones” and defines sense forming and semantic role of the embodiment of the cultural codes signs in the musical-sound score of the film by composer L. Hrabovskyi.
The practical significance. The artistic reconstruction of the folklore text in the film is based on the introduction of polystylistic tendencies and features of sound (timbre) thinking into the cinematographic process. Prospects for further study of this issue is the study of modern manifestations of artistic reconstruction of the folklore text, the processes of formation of semiotic space both in cinema and in culture in general.
Investigation of sinus vein thrombosis cases detected in the emergency department
Authors: ERDEM Ahmet Burak , ÇELİKEL Elif , YILMAZ Muhittin , KARAPINARLI Berkin , KAYA Uğur Bilgay 
Published: July 2021

Objective: Sinus vein thrombosis often presents to the emergency department with headache and is a rare disease among all strokes. Epidemiological data on sinus vein thrombosis are insufficient. Our aim in this study is to examine the findings of patients with sinus vein thrombosis who applied to our emergency department.
Material and Method: 267 patients with suspected sinus vein thrombosis in patients who came to our emergency department between 2013-2018 were included in the study. Patients were divided into 2 groups as present and without sinus vein thrombosis. Women were divided into 3 subgroups as not pregnant, pregnant and postpartum period. Demographic data, comorbid diseases, hemogram parameters and radiological data of the patients were recorded in a form. The relationship of the data with sinus vein thrombosis was examined.
Results: Sinus vein thrombosis was detected in 19.48% of the patients. 76.3% of the patients were women. 65.4% of them were between the ages of 18-40. The most common complaint was headache with 51.9%. And most of the patients’ neurological examinations were normal. We found that hemoglobin
Investigation of factors associated with nausea and vomiting in pregnant women
Authors: MIZRAK ŞAHİN Berrak 
Published: July 2021

Aim: In the study, it was aimed to determine the factors that may be associated with nausea and vomiting in pregnant women.
Material and Methods: The research was conducted between November 2020 - February 2021. The sample consisted of 434 pregnant women. Included were primiparous and multiparous pregnant women aged 18 and older, at 6-16 weeks of gestation, able to read, write and understand the Turkish language. "Personal Information Form" and "Pregnancy-Unique Quantification of Emesis and Nausea - PUQE" were used as data collection tools. The data were collected by online questionnaire created in Google Forms. The data obtained from the study were analyzed using a statistical package program. A value of p
The predictors of complicated acute appendicitis: large unstained cells, gamma-glutamyl transferase, monocyte to platelet ratio, age and gender
Authors: SUREL Aziz Ahmet , GÜNGÖRER Bülent 
Published: July 2021

Aim: In this study, we sought to investigate possible biomarkers markers that can preoperatively distinguish complicated and non-complicated acute appendicitis.
Material and Method: Patients who underwent appendectomy between February and December 2019 were screened retrospectively. Patients with pathology findings other than appendicitis were excluded. Patients with a confirmed diagnosis of acute appendicitis were categorized as complicated and non-complicated appendicitis for analysis of sociodemographic characteristics, comorbidities and preoperative laboratory parameters.
Results: A total of 575 patients were included in the study. Among these, 432 (75.1%) were diagnosed with non-complicated appendicitis and 143 (24.9%) were diagnosed with complicated appendicitis. The mean (SD) age was 34.2±14.2 years. Hypertension, diabetes mellitus and hypothyroidism were the most frequent comorbidities. Age (OR, 1.026; p=0.010), male gender (OR, 1.837; p=0.044), LUC (OR: 19.868; p=0.034) and GGT (OR: 1.013; p=0.013) were associated with a higher risk of complicated appendicitis. An increase in monocyte to platelet ratio (MPR) (OR: 0.920; p=0.047) was associated with a lower risk of complicated appendicitis.
Conclusion: In patients with acute appendicitis, parameters including age, gender, as well as LUC, GGT and MPR, which are easily available and relatively cheap biomarkers, can be useful to distinguish non-complicated and complicated cases preoperatively.
The effects of anogenital condylomas on female sexuality and psychology: a case-control study
Authors: AĞAR Eser , ŞAHİN AKER Seda 
Published: July 2021

Objective: HPV is a sexually transmitted virus with over two hundred subtypes. It can cause anogenital condyloma, cervical dysplasia, and cervical cancer. HPV types 6 and 11 are responsible for anogenital condylomas. The effect of condylomas on female sexual life and psychological state is investigated in our study.
Material and Methods: Seventy-six vulvar condyloma patients and 80 participants as the control group were included in the study after excluding the subjects not meeting the inclusion criteria. After an initial evaluation, condylomas excised using carbon dioxide laser followed by a medical assessment in the 3rd post-excisional month. FSFI and BDI scales were used on a group of healthy patients with anogenital condyloma at 0-3 months.
Results: There was a statistically significant difference in the FSFI scores at 0 and 3 months between the case and control groups (p
Prognostic value of blood gas lactate levels among COVID-19 patients who visited to emergency department
Authors: KURT Erdem , BAHADIRLI Suphi 
Published: July 2021

Objective: Our aim in this study, to determine the relationship between the mortality status and the ICU requirement of COVID-19 patients, with their blood gas lactate levels at the time of admission to the ED.
Material and method: This study was planned as retrospectively, all COVID-19 patients over the age of 18 who were admitted to the ED, had oropharyngeal /nasopharyngeal swabs and hospitalized between April 1, 2020 and June 31, 2020 were included. The primary outcome was in-hospital mortality. The secondary outcome is to determine the relationship between lactate levels and the ICU requirement
Results: The study was completed with 265 patients after the inclusion and exclusion criteria were applied. The median (IQR) age of the patients was 43.0 (31.0 – 59.0), and 132 (49.8%) were female. The comorbid diseases are; hypertension (HT), cardiovascular disease and diabetes mellitus (DM) were in the first three places with 23.0%, 17.0%, 9.1%, respectively. The cut-off value of lactate to determined for ICU admissions was 2.92, and 4.25 for mortality.The AUC for ICU requirement was 0.718 ± 0.038 (95% CI, 0.644 - 0.792), and AUC for mortality was 0.752 ± 0.058 (95% CI, 0.637 - 0.867), (p
PECULIARITIES OF ETHANOL INTOXICATION OF ANIMALS AT APPLICATION OF INTERMITTENT HYPOXIC TRAINING AT THE BEGINNING OF ALCOHOL CONSUMPTION
Authors: Kozak L.P. 
Published: July 2021

Relevance. It was shown a wide therapeutic effects of intermittent hypoxic training (IHT) on the human organism which can increase the organism's resistance to damaging factors by inducing mechanisms of the safety use of energy resources.
The objective: to investigate the protective effect of IHT applied at the beginning of the 30-day alcohol intoxication of rats on the redox processes and the state of the antioxidant system of blood and liver tissues.
Materials and methods. The study was performed on white male rats, which were divided into four groups: the first - intact (control); animals of the second group received a 15% ethanol solution for 30 days as the only source of drink; third - animals under IHT; fourth - rats that IHT was applied at the beginning of 30 days alcohol intoxication. The amount of the consumed ethanol was monitored during the experiment. Intermittent hypoxic training was performed in the altitude chamber in the following mode: five 10-min “elevations” to a height of 6 km at a rate of 20 m/sec, intervals between the elevations being 30 min. The activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), total antioxidant activity (IAOA), as well as the content of lactic and pyruvic acids, malone dialdehyde and diene conjugates were determined. The research materials were homogenates of liver tissues and blood. The process is two-phase, which obviously reflects the stages of alcoholism.
Results. It was found that alcohol intoxication of animals adapted to IHT is accompanied by an increase in the activity of superoxide dismutase and glutathione peroxidase in the blood and liver tissue against rats that consumed ethanol as the only source of drink. A tendency to increase IAOA and catalase activity against rats that received ethanol for a long time under these conditions was revealed. Analyzing the process of consumption of ethanol solution by animals, we can conclude that animals have a pronounced craving for alcohol in this model of alcoholization. The application of IHT at the beginning of alcohol intoxication as a protective agent delays the phase of formation of a pronounced craving for ethanol and reduces the amount of daily alcohol consumption.
Conclusions. Thus, sessions of short-term hypoxic effects at the beginning of chronic ethanol consumption, provide an increase in the antioxidant defence of these animals relative to rats with alcohol intoxication.
IMPROVEMENT OF THE ANALYTICAL CONTROL FOR APPLICATION OF PESTICIDES IN THE SYSTEM OF CHEMICAL PROTECTION OF CHICKPEA
Authors: Korshun О.М. , Lipavska А.О. , Milokhov D.S. , Аvramchuk А.О. , Omelchuk S.T. 
Published: July 2021

Relevance. To date, there are no approved methods in Ukraine for the determination of azoxystrobin, thiabendazole, fludioxonil and pyridate in grain chickpeas. Therefore, there is a need for scientific substantiation of the method selection, the development of conditions for sample preparation of chickpea grain, qualitative identification and quantification of pesticides in this matrix used in protection system of chickpea was given in the article, which will allow to control the established hygienic standards of pesticides and minimize pesticide negative impact on population health and the environment.
Objective of the research is to develop methods for the determination of azoxystrobin, thiabendazole, fludioxonil and pyridate in grain chickpea.
Materials and methods. Chromatographic analysis was performed by Shimazu (Japan) liquid chromatographs using ultraviolet and fluorescent detection.
The package of IBM SPSS StatisticsBase v.22 and MS Exel statistical programs was used for statistical processing of results.
Results. Optimal conditions of sample preparation of chickpea grain and chromatographic determination of azoxystrobin, fludioxonil, thiabendazole and pyridate (as the sum of pyridate and its metabolite – pyridafol) with the limits of quantitative determination of 0.1; 0.1; 0.01 and 0.05 mg/kg, respectively, wеre developed to provide the determination of the analyzed compounds at the required level (the measure of correctness is (72–75)%) and the control of the established hygienic standards of these compounds in chickpea grain.
Conclusions. Developed methods for determination of azoxystrobin, fludioxonil, thiabendazole and pyridate in chickpea grain by high-performance liquid chromatography allow to control the established hygienic standards, to obtain representative information on the content of pesticide residues, which is a prerequisite for risk assessment of plant protection products.
FORMULATION AND EVALUATION OF CLOPIDOGREL BISULFATE TRANSDERMAL PATCHES
Authors: Reddy P. Srikanth , Alagarsamy V. , Ravi G. , Bose P. Subhash Chandra , Saritha D. 
Published: July 2021

Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. The main objective of the present work was to develop a suitable matrix type transdermal drug delivery system of Clopidogrel bisulphate using different polymers HPMC E15, Eudragit L100 and to compare the drug release through physical method and chemical method. Matrix type transdermal patches containing Clopidogrel Bisulfate were prepared by solvent evaporation technique. The prepared transdermal patches were evaluated for Thickness, folding endurance, tensile strength and in vitro studies. The prepared transdermal drug delivery system of Clopidogrel bisulphate using different polymers such as HPMC E15 and Eudragit L 100 had shown good promising results for all the evaluated parameters. Based on the In-vitro drug release, drug content and folding endurance results formulation F4 was concluded as an optimized formulation which shows its higher percentage of drug release.
Keywords: Transdermal drug delivery, Clopidogrel bisulphate, HPMC E15, Eudragit L100
Evaluation of the range of fertilizers and methods of their application for a new variety of fiber flax Universal
Authors: Sorokina Olga Yu. 
Published: July 2021

Relevance. The productivity and especially the quality of flax products largely depend on a set of technological techniques that take into account varietal characteristics, agrochemical properties of the soil and the fertilizers used. Identification of the reaction to the production process of a new high-yielding flax variety of Universal is an important element of agricultural technology.Methods. The sod-podzolic medium loamy soil is characterized by a slightly acidic reaction of the soil solution pHKCl-5.44, a very high content of phosphorus (298 mg/kg) and medium potassium (85 mg/kg), low humus — 2.05%, medium boron (0.33 mg/kg), low zinc (0.56 mg/kg). The HTC (hydrothermal coefficient) for May — August by year was — 1.56 optimal (2017), — 1.09 arid (2018), — 1.80 wet(2019).Results. Studies have shown that the Universal flax variety has a high responsiveness to the use of fertilizers. The yield increases were: for flax straw 24 to 43%, for flax seeds from 27 to 49%, depending on the form of fertilizer and the method of their application. The advantage of the complex organomineral OMU “Universal” and mineral nitrogen-phosphorus-potassium with boron containing trace elements over the azofoska in equalized doses of nitrogen is noted. The increase in the yield of the flax stock of these fertilizers with the row method of application was lower by 40 and 34% of their main application, but the profitability of this method increased from 46 to 234% and from 62 to 219%. The application of organic fertilizer Sivid — Bor for seed treatment and Sivid-Zinc for crop processing on the background of reducing the dose of azofoski from 1.5 to 1.0 c/ha allowed to raise close to making azofoski of 1.5 c/ha, but with a greater profitability of 115%.
Assessment of the viability of cultures of lactic acid microorganisms during their freezing and low-temperature storage
Authors: Malik Nina I. , Guleychik Irina A. , Malik Evgeny V. , Chupahina Nataliya A. , Rusanov Ivan A. , Samohvalova Nadezhda S. , Safronova Vera I. 
Published: July 2021

Relevance. A significant increase in microbiome-associated diseases, closely related to violations of the bacterial diversity and functions of the normal intestinal microbiota, dictates the need to develop and implement measures for the long-term preservation of individual representatives of the normal microbiota in order to create new strategies for modifying the composition of microbiomes.Methods. The influence of the technology of deep freezing and storage of intestinal isolates of lactic acid bacteria of 2 taxonomic groups isolated from poultry in the conditions of the Low-temperature automated storage of biological samples of the Departmental Collection of useful microorganisms for Agricultural purposes of the Russian Agricultural Academy (VKSM) on the MRS culture medium using 10 and 20% glycerin or 10 and 20% sucrose as cryopreservants was studied. The suspensions of the isolates were frozen at - 150 °C for 18 hours and then placed in an automated cryopreservation at -80 °C. Control of samples for safetyResults. The technology of cryofreezing of lactic acid bacteria on MRS-broth using 10 and 20% glycerin or 10 and 20% sucrose as cryopreservants allows preserving the viability, physiological and biochemical properties of intestinal isolates of lactic acid bacteria when stored for 18 months. All the protective media used (MRS-broth with glycerin 10 and 20%, MRS -broth with sucrose 10 and 20%) showed comparable results in the preservation of viability and acid-forming activity of Lactobacillus fermentum-2, Pediococcus pentosaceus 6p-3, Pediococcus pentosaceus 28p-1 isolates. Then the storage of Pediococcus pentosaceus isolate (28p-1) in a given parameter on a protective medium with 10 and 20% sucrose led to a decrease in the activity of acid formation.