bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Occult Colon Cancer with Sepsis as the Primary Manifestation Identified by Bone Marrow Puncture
Authors: wang hua jun , zhou chenjie 
Published: July 2021

Abstract
Background: Bone marrow metastasis is common in liver cancer and lung cancer, but there are few reports in colon cancer. To date, there are no research reports from mainland China; in particular, reports of bone marrow metastasis combined with septic shock as the main manifestation are even rarer. We hope that this case report can raise clinical awareness of the insidiousness of colon cancer and the possibility of metastasis to the bone marrow, especially for patients with progressive thrombocytopenia that is difficult to correct, should be treated differently from sepsis. Case presentation: A 71-year-old elderly woman presented with sepsis as the first symptom, which mainly manifested as high fever, low blood pressure, high inflammatory indicators, etc. CT examination revealed mild inflammation of the lungs and no obvious abnormalities in the abdomen. Blood culture suggested Escherichia coli and Aeromonas hydrophila/caviae. After anti-infective treatment, the patient's sepsis symptoms improved significantly, but after repeated platelet transfusion, her hypothrombosis had still not been corrected. Finally, a large number of malignant cells were identified through a bone marrow puncture smear, and further PET-CT examination confirmed that a malignant tumor in the ascending colon accompanied by multiple metastases, such as in the liver and bones. This patient was ultimately confirmed to have colon adenocarcinoma buy autopsy. Conclusions: Colon cancer can have bone marrow metastasis, and it can be accompanied by intractable thrombocytopenia. Bone marrow aspiration may help distinguish between transient thrombocytopenia associated with sepsis.
Stability and Periodicity in a Mosquito Population Suppression Model Composed of Two Sub-models
Authors: Zhu Zhongcai , Zheng Bo , Shi Yantao , Yan Rong , Yu Jianshe 
Published: July 2021

Abstract
In this paper, we propose a mosquito population suppression model which is composed of two sub-models switching each other. We assume that the releases of sterile mosquitoes are periodic and impulsive, only sexually active sterile mosquitoes play a role in the mosquito population suppression process, and the survival probability is density-dependent. For the release waiting period T and the release amount c , we find three thresholds denoted by T ∗ , g ∗ and c ∗ with g ∗ < c ∗ . We show that the origin is a globally or locally asymptotically stable equilibrium when c ≥ c ∗ and T ≥ T ∗ , or c ∈ ( g ∗ ,c ∗ ) and T < T ∗ . We prove that the model generates a unique globally asymptotically stable T -periodic solution when either c ∈ ( g ∗ ,c ∗ ) and T = T ∗ , or T > T ∗ for any c > g ∗ . We give numerical examples to illustrate our theoretical results and make comparisons with some known models in the literature.
Early aEEG can Predict Neurodevelopmental Outcomes at 12- To 18- Month of Age in VLBWI with NEC: A Cohort Study
Authors: Chen Si , Xiao Xiuman , Lin Su , Zhu Jianghu , Liang Lidan , Zhu Minli , Yang Zuqin , Chen Shangqin , Lin Zhenlang , Liu Yanli 
Published: July 2021

Abstract
Background Studies have shown that neurological damage is not uncommon in NEC survivors. The purpose of the study was to investigate the predictive value of amplitude integrated electroencephalogram (aEEG) for neurodevelopmental outcomes in preterm infants with neonatal necrotizing enterocolitis (NEC).Methods Infants with NEC (n=13) were selected, and the control group was selected according to 1:1-2 pairing by gestational age. We performed single-channel (P3-P4) aEEG in two groups. The Burdjalov score system was evaluated and compared between the two groups. Cranial magnetic resonance imaging (MRI) was performed at term equivalent age. And the neurological outcomes at 12-18 month of age were compared with Gesell Developmental Schedules (GDS).Results There was good consistency between the two groups in general conditions, except for the highest C-reactive protein (CRP) and incidence of thrombocytopenia. In the 1st aEEG examination, the incidence of retardation in Co (7/10:0/16), Cy (8/10:0/16), LB (6/10:0/16), B (8/10:0/16) and Total score(9/10:0/16) were significantly increased in the NEC group (p≤0.01). Cranial MRI in NEC group revealed widened inter-parenchymal space with decreased myelination. The Gesell Developmental Schedules (GDS) assessment indicated that NEC children had inferior performance and lower mean scores in the sub-domains of gross motor (73.12±10.742:94.13±10.366, P<0.001), fine motor (68.15±10.323:100.04±12.608, P<0.001), adaptive behavior (74.79±9.774:100.24±12.175, P<0.001), language (68.59±12.593:96.37±11.493, P<0.001), personal-social responses (82.36±16.013:97.58±11.834, P=0.010) and in overall DQ (73.08±8.901:98.02±9.289, P<0.001). The results of the logistic binary regression analysis revealed that NEC patients had a significantly increased risk of neurodevelopmental retardation compared to no NEC patients (aOR = 27.00, 95% CI 2.561 – 284.696, P = 0.006). Confirmed by Spearman’s rank correlation analysis, the neurodevelopmental outcome was significantly affected by 1st aEEG Burdjalov score (r=0.603, p=0.001). The abnormal 1st Burdjalov score has predictive value for neurodevelopmental retardation with high specificity (84.62%) and positive predictive value (80.00%).Conclusions Early aEEG in NEC patients suggested inhibition of brain function. NEC children are more likely developing neurodevelopmental delay. And there’re high specificity and PPV of the early aEEG in predicting neurodevelopmental retardation.
ECMO After Cardiac Surgery: A Single Center Study On Survival And Optimizing Outcomes
Authors: Brewer Jennifer , Tran Anthony , Yu Jielin , Ali Mohammed I , Poulos Constantine , Gates Jonathan , Gluck Jason , Underhill David 
Published: July 2021

Abstract
BackgroundThe study purpose is to examine survival prognostic and extracorporeal membrane oxygenation (ECMO) application outcomes at our tertiary care center.MethodsThis is a retrospective analysis, January 2014 to September 2019. We analyzed 60 patients who underwent ECMO after cardiac surgery. All inpatients with demographic and intervention data was examined. 52 patients (86.6%) had refractory cardiogenic shock, 7 patients (11.6%) had pulmonary insufficiency, and 1 patient (1.6%) had hemorrhagic shock, all patients required either venous-arterial (VA) (n=53, 88.3%), venous-venous (VV) (n=5, 8.3%) or venous-arterial-venous (VAV) (n=2, 3.3%) ECMO for hemodynamic support.ECMO parameters were analyzed and common postoperative complications were examined in the setting of survival with comorbidities.ResultsIn-hospital mortality was 60.7% (n=37). Patients who survived were younger (52 ± 3.3 vs 66 ± 1.5, p < 0.001) with longer hospital stays (35 ± 4.0 vs 20 ± 1.5, p < 0.03). Survivors required fewer blood products (13 ± 2.3 vs 25 ± 2.3, p = 0.02) with a net negative fluid balance (-3.5 ± 1.6 vs 3.4 ± 1.6, p = 0.01). Cardiac re-operations worsened survival.ConclusionECMO is a viable rescue strategy for cardiac surgery patients with a 40% survival to discharge rate. Careful attention to volume management and blood transfusion are important markers for potential survival.
Production of Activated Carbon Electrode for Energy Storage Application in Supercapacitors via KOH Activation of Waste Termite Biomass
Authors: Kalu-Uka Godwin Mong , Kumar Shubham , Kalu-Uka Abraham Chinedu , Vikram Shruti , Ihekweme Gina Odochi , Ranjan Nishant , Anosike-Francis Esther Nneka , Prajapati Gaurav , Nduba Anayo , Onwualu Azikiwe Peter , Kumar Sandeep 
Published: July 2021

Abstract
The devastating effects of termites on wood and the contribution of termite activities to the rising levels of atmospheric CO2 and CH4 constitute a serious threat to global economy and the ozone layer. In order to stall the contribution of termites to the rising levels of greenhouse gases, this work considers the conversion of termite biomass to activated carbon electrode. The waste termite biomass obtained during the production of termite biodiesel was converted to activated carbon electrode by a one-step carbonization-activation process, using potassium hydroxide as activating agent. The optimal specific surface area of the activated carbon was recorded at 900 oC, 9 h and 3:1 KOH-biomass ratio. The surface morphology and functionalization of the activated carbon were examined using the SEM, TEM, XRD, Raman and XPS characterization techniques. The electrochemical performance of the activated carbon electrode was tested in aqueous (1 M H2SO4) and ionic liquid (1 M EMImBF4) electrolytes. Results obtained from cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance experiments showed that the specific capacitance of the activated carbon electrode was higher in 1 M H2SO4 (78 Fg-1 at 0.5 Ag-1) than in 1 M EMImBF4 (53 Fg-1 at 0.5 Ag-1). However, after completing 10, 000 chare-discharge cycles at 10 Ag-1, the activated carbon electrode lost ~ 5% of its specific capacitance in 1 M H2SO4 and ~ 2% of its capacitance in 1 M EMImBF4. Overall, the results showed that waste termite biomass could be valorised in the production of activated carbon for energy storage in supercapacitors.
Association Between Sleep Pattern and Depression in South Korean Adults: Sleep Duration and Sleep Inconsistency Between Weekdays and Weekends
Authors: Kim Nam-Hwa , Lee Bo-Hyun , Cho Young-Woo , Park Yoon Sik , Park Eun-Cheol 
Published: July 2021

Abstract
ObjectivesThis study aimed to understand the relationship between sleep duration, inconsistency between weekdays and weekends and depression.MethodsA total of 10,205 participants were included in the 2016 and 2018 Korea National Health and Nutrition Examination Survey. Sleep duration over a week was calculated by averaging sleep durations on weekdays and weekends. Sleep duration ratio was defined as sleep duration on weekends divided by that on weekdays and depression as Patient Health Questionnaire scores higher than 5. We stratified the participants by sex and analyzed using multiple logistic regression.ResultsIn men, those who slept more than 9 hours was compared to those who slept between 7 and 7.9 hours. In women, those who slept less than 5.9 hours related to be more depressed. In men who slept for more than 9 hours and over 1.01 times more on weekends than on weekdays showed the highest chance of depression. In women, the highest odds ratio was associated with those who slept less than 5.9 hours and slept more on weekdays than on weekends.ConclusionsIn men, sleep durations that were too short or long were associated with depression. In women, extremely short sleep durations were associated with depression.
The Compensatory Increased BDNF and NGF in Patients With Multiple Sclerosis Following Home-based Aerobic Training and Vitamin D Supplementation During the COVID-19 Outbreak
Authors: Bahmani Elahe , Hoseini Rastegar , Amiri Ehsan 
Published: July 2021

Abstract
Background: Lifestyle modifications (physical activity and diet) are among the most promising strategies in MS rehabilitation. This study aimed to investigate the effect of home-based aerobic training and vitamin D supplementation in patients with multiple sclerosis during the COVID-19 outbreak.Methods: In this randomized, single-blinded, placebo-controlled trial, 38 females with Multiple sclerosis with EDSS: 3-5 (aged 20–40 years with body mass index [BMI] of 25–30 kg/m2) were randomly assigned into four groups: aerobic training + Vitamin D supplementation (AT+Vit D; n=10); aerobic training (AT; n=9); Vitamin D supplementation (Vit D; n=9), and Control (Placebo) (n=10). The AT program consisted of 50-70% of HRMax, 25-40 min/day, three days/wk for eight weeks. Participants in the Vit D group consumed 50000 IU of Vitamin D supplement capsules per week for eight weeks. The data were analyzed through paired t-test and one-way analysis of variance, as well as Tukey's post hoc test at the signification level of P<0.05.Results: BDNF and NGF levels improved significantly from pre-test to post-test within all experimental groups. BDNF and NGF decreased significantly in AT+Vit D, AT, and Vit D compared to C. Also, the results show that the AT+Vit D had significantly lower BDNF and NGF compared to AT (P=0.023 and P=0.011) and Vit D (P=0.001 and P=0.002). Conclusions: These findings suggest that the combination of AT+Vit D improves BDNF and NGF status more effectively than AT or Vit D alone in female Multiple sclerosis patients.
Whole Genome Sequencing of Clinical Samples Reveals Extensively Drug Resistant Tuberculosis (XDR TB) Strains From The Beijing Lineage in Nigeria, West Africa.
Authors: Olawoye Idowu Bolade , Uwanibe Jessica N. , Kunle-Ope Chioma N. , Davies-Bolorunduro Olabisi F. , Abiodun Temitope , Audu Rosemary , Salako Babatunde , Happi Christian 
Published: July 2021

Abstract
Multi-drug (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) continues to be a global public health problem especially in high TB burden countries like Nigeria. Many of these cases are undetected and go on to infect high risk individuals. Clinical samples from positive rifampicin resistant Xpert®MTB/Rif assay were subjected to direct whole genome sequencing and bioinformatics analysis to identify the full antibiotics resistance and lineage profile. We report two (2) XDR TB samples also belonging to the East-Asian/Beijing family of lineage 2 Mycobacterium tuberculosis complex (MTBC) from clinical samples in Nigeria. Our findings further reveal the presence of resistance genes to first-line drugs (rifampicin, isoniazid, ethambutol and pyrazanimide), second-line injectables (capreomycin, streptomycin, kanamycin and/or amikacin) and at least one of the fluoroquinolones (ofloxacin, moxifloxacin, levofloxacin and/or ciprofloxacin) in both samples. The genomic sequence data from this study not only provide the first evidence of XDR TB in Nigeria and West Africa, but also emphasize the importance of WGS in accurately detecting MDR and XDR TB, to ensure adequate and proper management treatment regimens for affected individuals. This will greatly aid in preventing the spread of drug resistance TB in high burden countries.
Mid-to-long-term Results of Hemi-resurfacing Arthroplasty and Metal-on-metal Hip Resurfacing Arthroplasty for Osteonecrosis of the Femoral Head
Authors: Hasegawa Masahiro , Tone Shine , Naito Yohei , Wakabayashi Hiroki , Sudo Akihiro 
Published: July 2021

Abstract
Background: Hemi-resurfacing arthroplasty (Hemi) and metal-on-metal hip resurfacing arthroplasty (HRA) are alternatives to conventional total hip arthroplasty (THA) for patients with osteonecrosis of the femoral head (ONFH). Mid- to long-term results were evaluated.Methods: Twenty-three hips with osteonecrosis of the femoral head were treated, using Hemi in 12 and HRA in 11. Mean follow-up was 13.8 years in the Hemi group and 8.7 years in the HRA group. Mid- to long-term clinical scores, radiographic results, and survivorship were reviewed retrospectively.Results: In the Hemi group, 8 hips were revised to THA due to migration. In the HRA group, 1 hip was revised due to adverse local tissue reaction. No evidence of any femoral loosening or neck narrowing was seen in either group. Clinical score was superior with HRA compared to Hemi. Ten-year survival rates were 64.2% and 90.9% in the Hemi and HRA groups, respectively. Survival rate in the Hemi group dropped to 22.0% at 14 years.Conclusion: Hemi did not represent a better alternative to THA for patients with ONFH. HRA could offer attractive indications for 10 years.
Nanofiber Template-Induced Preparation of ZnO Nanocrystal and its Application in Photocatalysis
Authors: Chen Rouxi , Chen Mingyi , Liu Peng , Wang Hsing-Lin , Wang Xin , He Ji-Huan 
Published: July 2021

Abstract
Traditional preparation of ZnO nanocrystal requires heating zinc acetate to a temperature over 350°C, whereas in this work, zinc acetate was first electrospun with PVDF to form a nanofiber, followed by thermal treatment at only 140°C to give nanocrystalline ZnO. The much lower temperature required in thermal treatment is attributed to the high reactivity of zinc acetate at nano dimension. The as-prepared ZnO-doped PVDF nanofiber mat shows excellent effect in the photocatalytic degradation of Rhodamine B, comparable to ZnO particle thermally treated at 600°C. Highly-oriented ZnO nanorods were obtained by further hydrothermal synthesis of the electrospun nanofiber mat, giving nanostructured ZnO of different morphologies well-aligned on the surface of organic nanofiber. Notably, the hydrothermal synthesis of the successful preparation of these nanostructured ZnO requires a processing temperature below 100°C at atmospheric pressure, showing great potential to be scaled up for vast manufacturing.
MCM7 Ubiquitination Regulates CMG Helicase Disassembly In Human
Authors: Sun Qianqian , Liu Kun , Li Fangzhou , Qiu Bingquan , Fu Zhisong , Mao Zebin , Tong Tanjun , Zhao Wenhui 
Published: July 2021

Abstract
The disassembly of the replisome plays an essential role in maintaining genome stability at the termination of DNA replication. However, the mechanism of replisome disassembly remains unknown in human. In this study, we screened E3 ligases and deubiquitinases (DUBs) for the ubiquitination of minichromosome maintenance protein (MCM) 7 and provided evidence of this process driving CMG helicase disassembly in human tumor cells. Our data identified two important features of helicase disassembly in human. First, RNF8 catalyzes the K63-linkedpolyubiquitylation of MCM7 on chromatin, which is transiently modified mainly in the late S phase of the cell cycle. Moreover, the proteasome, p97 segregase, USP29 and ATXN3 are required for the removal of MCM7 ubiquitination to promote the disassembly of CMG on chromatin. Our study will help to uncover the novel role of the regulation of CMG helicase disassembly via MCM7 ubiquitination.
Simultaneous Arterial and Venous Brain Infarctions in a Patient with COVID-19.
Authors: Bermúdez Sonia , Forero Paula , Salej Vanessa , González Silvia , Toro Jaime 
Published: July 2021

Abstract
Introduction: Stroke is one of the manifestations of COVID-19 associated coagulopathy. Arterial infarcts are the most common presentation, however involvement of both arterial and venous irrigation is possible but rare. We report, what is, to our knowledge, the second case of concomitant arterial and venous brain thrombosis evidenced in magnetic resonance. Case presentation: A 62-year-old man presented with acute weakness of the left hand and lack of coordination in the left arm. Nine days earlier, he was positive for SARS-CoV-2 RT-PCR. The brain images revealed two subacute infarcts, one corresponding to the territory of the right middle cerebral artery, and the other in the right frontal cortical vein. Conclusion: The existence of both venous and arterial brain infarcts due to COVID-19 infection, has been previously reported once. Most of the cases of stroke are due to only arterial thrombosis, therefore this could be the starting point to start collecting data about simultaneous compromise in order to assess and compare outcomes, severity of the disease, among other variables.
Development of Ritonavir Loaded Nanostructured Lipid Carriers Employing Quality By Design (QbD) As A Tool: Characterizations, Permeability, And Bioavailability Studies
Authors: Gurumukhi Vishal , Bari Sanjaykumar 
Published: July 2021

Abstract
The objective of the present work was to optimize ritonavir (RTV) loaded nanostructured lipid carriers (NLCs) to improve bioavailability using quality by design (QbD) based technique. Risk assessment was studied using ‘cause and effect’ diagram followed by failure mode effect analysis (FMEA) to identify the effective high-risk variables for the formulation development. Quality target product profile (QTPP) and critical quality attributes (CQAs) were initially assigned for the proposed product. Central composite rotatable design (CCRD) was used to identify the individual and combined interactions of formulation variables. RTV loaded NLC (RTV-NLC) was prepared using emulsification-ultrasonication method. The effect of formulation variables like ultrasound amplitude, lipid concentration, surfactant concentration on their responses like particle size, polydispersity index (PDI), and entrapment efficiency (EE) were studied by CCRD. The optimized formulation was subjected to lyophilization to obtain dry NLCs for solid-state analysis. DSC and PXRD investigations showed RTV was molecularly dispersed in lipid matrix indicating amorphous form present in the formulation. FESEM and AFM depicted the spherical and uniform particles. The enhanced solubility and dissolution may be attributed due to the reduced particle size. The optimized NLCs showed good physical stability during storage for six months. RTV-NLC was further subjected to in vitro studies and found a successful sustained release rate of 92.37±1.03 %. The parallel artificial membrane permeability assay (PAMPA) and everted gut sac model have demonstrated the permeation enhancement of RTV. In vivo study observed the enhanced bioavailability with 2.86 fold suggesting optimized NLC successfully overcome the issue of solubility.
The Effect of Temperature on Physical Activity: An Aggregated Analysis of Smartphone Users in Five Major Chinese Cities
Authors: Ho Janice Ying-en , Goggins William Bernard , Mo Phoenix Kit Han , Chan Emily Y. Y. 
Published: July 2021

Abstract
Background:Physical activity is an important factor in premature mortality reduction, non-communicable disease prevention, and well-being protection. Climate change will alter temperatures globally, with impacts already found on mortality and morbidity. While uncomfortable temperature is often perceived as a barrier to physical activity, the actual impact of temperature on physical activity has been less well studied, particularly in China. This study examined the associations between temperature and objectively measured physical activity among adult populations in five major Chinese cities. Methods:Aggregated anonymized step count data was obtained between December 2017-2018 for five major Chinese cities: Beijing, Shanghai, Chongqing, Shenzhen, and Hong Kong. The associations of temperature with daily aggregated mean step count were assessed using Generalized Additive Models (GAMs), adjusted for meteorological, air pollution, and time-related variables.Results:Significant decreases in step counts during periods of high temperatures were found for cold or temperate climate cities (Beijing, Shanghai, and Chongqing), with maximum physical activity occurring between 16-19.3°C. High temperatures were associated with decreases of 800-1500 daily steps compared to optimal temperatures. For cities in subtropical climates (Shenzhen and Hong Kong), non-significant declines were found with high temperatures. Overall, females and the elderly demonstrated lower optimal temperatures for physical activity and larger decreases of step count in warmer temperatures. Discussion: As minor reductions in physical activity could consequentially affect health, an increased awareness of temperature’s impact on physical activity is necessary. City-wide adaptations and physical activity interventions should seek ways to sustain physical activity levels in the face of shifting temperatures from climate change.