bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disciplinary differences in the language needs of engineering students in Iran: a cross-disciplinary analysis
Authors: Gholaminejad Razieh 
Published: January 2021

PurposeAlthough English for academic purposes (EAP) courses are vital components of engineering disciplines in the universities of Iran, studies investigating engineering students' English language needs are infrequent, and even more infrequent are studies comparing how the students of different engineering disciplines vary in their English language needs. Research demonstrates that students of different disciplines have different language needs, which requires competency in different language skills (Soruç et al., 2018). However, in the majority of Iranian universities, students of different engineering disciplines are taught similar subskills, through similar teaching methodologies and textbooks. With the twofold purpose of identification and comparison of the students' language needs and weaknesses, this study focuses on the perceptions of Iranian students of electrical, mechanical and chemical engineering at the undergraduate and postgraduate levels of their present language abilities and target-situation language needs.Design/methodology/approachOnline surveys regarding language needs and self-assessments were completed by 194 undergraduate students and 189 postgraduate students studying at Sharif University.FindingsWhile only educational level was found to have a significant effect on the perceptions of the respondents of their target needs, both educational level and discipline had a significant effect on the perceptions of the students of their present level of language proficiency. Furthermore, almost equal attention to the four language skills were considered necessary by the respondents, who also held that the number of credits devoted to the EAP courses was insufficient. A further finding was that the majority of the undergraduates required that the EAP courses be oriented toward English for specific purposes (ESP), whereas almost half of the postgraduates preferred that the EAP classes be geared toward general English.Originality/valueResearchers have so far analyzed the language needs of students of a number of academic disciplines. This study adds to the existing literature of needs-analysis by comparing the engineering students' present abilities and target language needs. This study is different from the existing publications on language needs-analysis in two ways. First, through a comparative perspective, a profile of engineering students' language needs is obtained, which can serve as a new database for curriculum developers and material designers of engineering programs. Second, investigating whether the students' perceptions of their language needs are affected by their educational levels and disciplines is a topic for which there is little information at present.
Disseminating early years research: an illustrative case study
Authors: O’Connor Siobhan , McGilloway Sinead , Hickey Grainne , Barwick Melanie 
Published: January 2021

PurposeThis paper aims to outline a knowledge translation (KT) case study undertaken as part of a multi-component research programme aimed at evaluating new parenting supports in the earliest years. The study aimed to: explore the influencing factors relating to research use in an early years context; and to use the findings, at least in part, to execute an integrated KT plan – to promote stakeholder engagement, greater research visibility and to enhance the understanding of findings emerging from the research programme.Design/methodology/approachA mixed-methods study was embedded within a large-scale, longitudinal research programme. In the present study, a national survey (n= 162) was administered to stakeholders working with children and families throughout Ireland. A series of one-to-one interviews were also undertaken (n= 37) to amplify the survey findings. Also, one focus group was carried out with parents (n= 8) and one with members of the research team (n= 3). Several dissemination strategies were concurrently developed, executed and evaluated, based partly on survey and interview findings and guided by the knowledge translation planning template (Barwick, 2008; 2013; 2019).FindingsThe main factors influencing the dissemination of evidence, as identified by the stakeholders – were: a lack of resources; an under-developed understanding of research use and dissemination; insufficient collaboration and communication; and conflicting stakeholder priorities. Despite these challenges, the research programme was found to benefit from a multi-component KT plan to achieve the outlined dissemination goals.Practical implicationsThe KT planning process allowed the research team to be more accountable, introspective and to work more efficiently. This helped increase the likelihood of more targeted and successful dissemination of the research findings, delivering a better return on research investment.Originality/valueThis is the first study of its kind (to our knowledge) to provide important insights for stakeholders in Ireland and elsewhere about how to improve the dissemination process. Effective KT planning can ultimately help to bridge the research-policy-practice gap and enable the effective translation of high-quality evidence in the early years’ sector to enhance outcomes for families in the shorter and longer-term.
Assessment of the accuracy of an intermittent‐scanning continuous glucose monitoring device in patients with type 2 diabetes mellitus undergoing hemodialysis (AIDT2H) study
Authors: Toyoda Masao , Murata Takashi , Saito Nobumichi , Kimura Moritsugu , Takahashi Hiroo , Ishida Naoto , Kitamura Makoto , Hida Miho , Hayashi Akinori , Moriguchi Ibuki , Kobayashi Naoyuki , Tsuriya Daisuke , Sakao Yukitoshi , Matsushita Takaya , Ito Yukie , Suzuki Shota , Kasama Shu , Kasahara Masato , Yamakawa Tadashi , Mori Katsuhito , Kuroda Akio , Miura Junnosuke , Hirota Yushi , Abe Masanori , Fukagawa Masafumi , Sakane Naoki , Hosoda Kiminori 
Published: January 2021

AbstractFreeStyle Libre has been approved for use in patients undergoing hemodialysis (HD) in Japan, unlike Europe and the United States; however, evidence regarding its accuracy in such patients is sparse. Forty‐one participants with type 2 diabetes undergoing HD were recruited. The overall mean absolute relative difference and mean absolute difference were 23.4% and 33.9 mg/dL, respectively. Sensor glucose levels and capillary glucose levels were significantly correlated (r = 0.858, P < .01), although the sensor glucose levels were significantly lower than the capillary glucose levels. The accuracy of FreeStyle Libre in patients undergoing HD became deteriorated with the days of usage. The percentage of sensor results in Zones A and B in the consensus error grid analysis and in the Clarke error grid analysis were 99.7% and 99.0%, respectively. Its insufficient accuracy necessitates adjunct usage of FreeStyle Libre with self‐monitoring of blood glucose in patients undergoing HD.
The association of TV viewing time with 2‐hour plasma glucose is modified by a prudent dietary pattern
Authors: Cao Yingting , Dunstan David W. , Sethi Parneet , Owen Neville 
Published: January 2021

AbstractBackgroundTV viewing is associated with elevated plasma glucose, but it is not clear whether such associations can be modified by dietary patterns.MethodsWe examined the interactions of TV viewing time and dietary patterns in relation to fasting and 2‐hour plasma glucose. Cross‐sectional analyses were performed among participants (N = 3081; 44.7% male; mean age 57.8 years) from the 2011 to 2012 Australian Diabetes, Obesity and Lifestyle Study (AusDiab) without clinically diagnosed diabetes or cardiovascular disease. Factor analysis (principal component) was conducted to identify dietary patterns. Multivariable linear regression models were used to examine distinct associations of TV viewing time and dietary patterns with fasting and 2‐hour plasma glucose. Dichotomous TV viewing time (low: ≤ 2 h/d vs high: >2 h/d) and quartiles of dietary patterns were further combined to examine the joint associations with plasma glucose.ResultsThree dietary patterns were identified: prudent, Western, and mixed. TV viewing time was positively associated (β = .01, P < .05) and the prudent dietary pattern was inversely associated (β = −.03, P < .05) with log transformed 2‐hour plasma glucose. Compared with participants with high TV viewing/lowest prudent dietary pattern, participants with low TV viewing/highest prudent diet had the lowest 2‐hour plasma glucose (β = −.05, P = .028). No interactions were found between TV viewing time and the Western dietary pattern, nor the mixed dietary pattern, in relation to either fasting or 2‐hour plasma glucose.ConclusionsFollowing a prudent dietary pattern may attenuate the adverse effect of TV viewing on 2‐hour plasma glucose. Prospective studies and intervention trials are needed to further clarify these relationships.
Melflufen plus dexamethasone in relapsed/refractory multiple myeloma: long‐term survival follow‐up from the Phase II study O‐12‐M1
Authors: Bringhen Sara , Voorhees Peter M. , Plesner Torben , Mellqvist Ulf‐Henrik , Reeves Brandi , Sonneveld Pieter , Byrne Catriona , Nordström Eva , Harmenberg Johan , Obermüller Jakob , Richardson Paul G. 
Published: January 2021

SummaryAn updated survival analysis was conducted for the Phase II study O‐12‐M1 of melphalan flufenamide (melflufen) plus dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM) with two or more prior lines of therapy (including bortezomib and lenalidomide). Partial response or better was seen in 31%. After a 46‐month median overall survival (OS) follow‐up, melflufen plus dexamethasone had a median OS of 20·7 months (75th percentile OS, 47·5 months). The median time‐to‐next treatment for melflufen plus dexamethasone was 7·9 months. In summary, melflufen plus dexamethasone resulted in sustained long‐term clinical benefit in patients with RRMM.
Patterns of urgent hoarseness referrals to ENT—When should we be suspicious of cancer?
Authors: Douglas Catriona M , Middleton Crawford , Sim Pauline , Wight Megan , Young David , MacKenzie Kenneth , Montgomery Jenny 
Published: January 2021

AbstractBackgroundCurrent UK referral criteria stipulate that hoarseness should be persistent to merit 2 week wait (2WW) or urgent suspicion of cancer (USOC) referral. This study delineates patterns of hoarseness presentation with a view to assisting referral pathways, and whereby reassurance could be provided.MethodsA pre‐existing database of patients referred with hoarseness under the urgent suspicion of cancer (USOC) category was analysed. Univariate and multivariate analyses were performed on a variety of demographic and comorbid features to produce odds ratios (OR) of features either related or not related to laryngeal cancer.ResultsOf 698 consecutive hoarseness referrals were studied. In these referrals there were 506(73%) with persistent hoarseness and 192(27%) with intermittent hoarseness. The most significant patient variables related to laryngeal cancer were persistent hoarseness (OR 4.97), recreational drug use (OR 4.94), male gender (OR 4.01) and weight loss (OR 3.75). Significant patient variables present not related to laryngeal cancer diagnosis were intermittent hoarseness (OR 0.2), the presence of cough (OR 0.2), globus sensation (OR 0.25) and recent viral infection (OR 0.29).ConclusionThe strongest association with cancer is seen in patients that are persistently hoarse. Patients with fluctuating hoarseness do not need an “urgent suspicion of cancer” referral. Additional demographic referral information could help to streamline the referral of these patients, and reassure others.
An international study of public contact with people who have an intellectual disability
Authors: McConkey R. , Slater P. , Dubois L. , Shellard A. , Smith A. 
Published: January 2021

AbstractBackgroundPeople with intellectual disability (ID) are often socially isolated, and many experience stigma and discrimination. Increased contact with the general public is thought to overcome prejudices. This large‐scale international study had three main aims: to determine the type and frequency of contact that the general public has with people with ID; to identify the personal characteristics of those who have greater contact; and to examine the public's level of comfort at the prospect of having contact with people with ID.MethodSelf‐completed online questionnaires were administered to nationally representative panels of respondents in 17 countries; totally 24 504 persons. Multivariate analyses were used to identify respondents more likely to have had frequent personal contact with persons with ID from those with infrequent or no contact and those respondents who were most comfortable at meeting a person with ID.ResultsInternationally around one in four of the general population reports having frequent personal contact with people who have an ID although this varied from 7% in Japan to 46% in Panama. The principal forms of contact were through friendships, neighbours or extended family members. Over all countries, volunteering and engagement with Special Olympics were the two main predictors of frequent personal contact followed by employment in the education, health or social care field, being a parent of children under 18 years, playing sports and being employed. People who reported frequent personal contact were also more comfortable at meeting a person with ID.ConclusionsThis international dataset provides a baseline against which public contact can be compared across countries and changes monitored over time. The findings suggest ways in which greater contact can be promoted and making the public more comfortable at meeting people with ID.
CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA‐485‐3p/zinc finger E‐box binding homeobox 1 axis
Authors: Xie Chen , Li Junyu , Xu Chen , Xiong Wenmin , Yuan Xia 
Published: January 2021

AbstractBackgroundCircular RNAs (circRNAs) are associated with tumorigenesis of breast cancer. Nevertheless, how and whether circRNA DNA methyltransferase 1 (circ‐DNMT1) controls breast cancer development remains poorly understood.MethodsThe paired tumor and paracancer tissues (n = 41) were obtained from breast cancer patients. Circ‐DNMT1, microRNA (miR)‐485‐3p, and zinc finger E‐box binding homeobox 1 (ZEB1) abundances were measured by quantitative reverse transcription polymerase chain reaction and western blot. Cell colony formation, migration, invasion, and apoptosis were analyzed by colony formation analysis, transwell analysis, and flow cytometry. Target relationship was evaluated via dual‐luciferase reporter analysis, RNA immunoprecipitation, and pull‐down. The in vivo experiments were conducted using a xenograft model.ResultsCirc‐DNMT1 and ZEB1 levels were upregulated in breast cancer, and miR‐485‐3p was downregulated. Circ‐DNMT1 knockdown restrained cell colony formation, migration, and invasion and increased apoptosis. MiR‐485‐3p was negatively regulated by circ‐DNMT1, and miR‐485‐3p knockdown mitigated the effect of circ‐DNMT1 silence on breast cancer development. ZEB1 was targeted via miR‐485‐3p, miR‐485‐3p overexpression repressed cell colony formation, migration, and invasion and triggered apoptosis by decreasing ZEB1. Circ‐DNMT1 silence reduced ZEB1 expression via regulating miR‐485‐3p. Circ‐DNMT1 knockdown reduced xenograft tumor growth.ConclusionCirc‐DNMT1 knockdown constrains breast cancer development via modulating miR‐485‐3p/ZEB1 axis.
Conservative management of grade 2 stage IA endometrial carcinoma and literature review
Authors: Shan Weiwei , Wu Pengfei , Yang Bingyi , Zhang Hongwei , Sun Li , Lv Qiaoying , Luo Xuezhen , Cheng Yali , Zhu Qin , Chen Xiaojun 
Published: January 2021

AbstractPurposeTo explore the clinical outcomes of megestrol acetate alone or plus metformin in young women with grade 2 stage IA endometrial carcinoma who ask for preserved fertility.MethodsPatients with stage IA grade 2 endometrial carcinoma who asked for fertility‐sparing treatment in the Obstetrics and Gynecology Hospital of Fudan University between 2015 and 2017 were enrolled and retrospectively reviewed.ResultsFour patients were included and treated with oral megestrol acetate (160 mg per day), while metformin (500 mg, thrice daily) was added for patients with metabolic syndrome. Regular hysteroscopic examination was performed every 3 months during the conservative treatment. Overall, 75% (3/4) of the patients had a complete response, one relapsed and achieved a complete response after changing the therapy plan, and one patient had an indication of myometrial invasion during fertility‐sparing treatment and chose to remove uterus.ConclusionsFertility‐sparing treatment for stage IA grade 2 endometrial carcinoma patients is worth exploration. Megestrol acetate with or without metformin combined with hysteroscopic lesion ablation may be an effective therapy.
A comparison of farming‐ and non‐farming‐related suicides from the United States’ National Violent Deaths Reporting System, 2003–2016
Authors: Kennedy Alison , Cerel Julie , Kheibari Athena , Leske Stuart , Watts James 
Published: January 2021

AbstractFarmers are at higher risk of suicide than other occupations and the general population. The complex suicide risk factors have not been examined in a large, population‐wide study across a significant time period. This observational study draws on existing data from the United States’ National Violent Death Reporting System (NVDRS), including 140,523 farming‐ or non‐farming‐related suicide decedents between 2003 and 2016 from across 40 states. “Farming‐related” decedents included 2,801 suicides. Farmers had higher odds of being male, older, less well‐educated, and American Indian/Alaska Native. Farmers had higher odds of using firearms and—when farmers used a gun—higher odds of using a long‐arm weapon. Farmers had lower odds of having a known mental health condition or job problem, and lower odds of having made a previous suicide attempt or leaving a suicide note. Findings highlight the complexity of suicide risk within the context of farming in the United States and reinforce the need for tailored prevention efforts; employing means restriction of firearms; and emphasizing that traditional risk factors may not be as common in the farming population.
Analytical Solution of Aluminum Alloy Plates With Holes Subjected to Cold Expansion With Reverse Yielding
Authors: Bouzid Abdel-Hakim , Touahri Hacène , Benfriha Khaled 
Published: January 2021

Abstract
The expansion induced by cold working is a common process that generates residual stresses. It is used when fatigue damage accumulation and life reduction of aluminum alloy perforated plates is an issue in the aeronautics industry. This process is an attractive solution to extend the fatigue lifetime of these structures. It aims at generating residual stresses and increases thereby the strength of hollow parts including aluminum alloy plates with holes commonly used in the manufacture of airplane fuselage. Unfortunately, the life predictions require a good prediction of the residual stresses and in particular when reverse yielding takes place. An analytical model to predict the residual stresses induced during the expansion process due to the cold strain hardening is developed. The proposed analytical model is based on an elasto-plastic behavior, with a power law material behavior and relies on the theory of autofrettaged thick wall cylinders in plane strain state to which reverse yielding is incorporated. The application of Hencky theory of plastic deformation is used in the analytical calculations of the stresses and strains. Finite element numerical simulation is used to validate the developed analytical model by comparison of the radial, hoop, longitudinal, and equivalent stresses for both the loading and unloading phases. The obtained results show clearly that the level of residual stresses depend mainly on the interference and strain hardening while reverse yielding reduces the stresses near the hole.
A New Hierarchy for Automaton Semigroups
Authors: Bartholdi Laurent , Godin Thibault , Klimann Ines , Noûs Camille , Picantin Matthieu 
Published: January 2021

We define a new strict and computable hierarchy for the family of automaton semigroups, which reflects the various asymptotic behaviors of the state-activity growth. This hierarchy extends that given by Sidki for automaton groups, and also gives new insights into the latter. Its exponential part coincides with a notion of entropy for some associated automata. We prove that the Order Problem is decidable whenever the state-activity is bounded. The Order Problem remains open for the next level of this hierarchy, that is, when the state-activity is linear. Gillibert showed that it is undecidable in the whole family. We extend the aforementioned hierarchy via a semi-norm making it more coarse but somehow more robust and we prove that the Order Problem is still decidable for the first two levels of this alternative hierarchy.
Os anos de formação na Europa, 1964-1970
Authors: Rolland Denis 
Published: January 2021

Este é um itinerário em meados do século XX: ser brasileiro na França após o golpe de Estado contra João Goulart, um "refugiado" sem status além do de estudante, sem dinheiro; um estudante estrangeiro na França em uma grande universidade do interior antes e durante 1968. Seja um sul-americano descobrindo, além da França, este Velho Mundo da Guerra Fria, as duas Europas, de ambos os lados do Muro, e o Oriente Médio.
Intended Bridging Therapy or Intravenous Thrombolysis Alone in Minor Stroke With Basilar Artery Occlusion
Authors: Seners Pierre , Dargazanli Cyril , Piotin Michel , Sablot Denis , Bracard Serge , Niclot Philippe , Baron Jean-Claude , Turc Guillaume , Perrin Claire , Arquizan Caroline , Lamy Chantal , Sibon Igor , Obadia Michael , Papassin Jérémie , Henon Hilde , Preterre Cécile , Suissa Laurent , Debiais Séverine , Lyoubi Aïcha , Garnier Pierre , Girard-Buttaz Isabelle , Lapergue Bertrand , Triquenot Aude , Duong Duc-Long , Laksiri Nadia , Mione Gioia , Mas Jean-Louis 
Published: January 2021

Background and Purpose:
Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with basilar artery occlusion remains uncertain.

Methods:
Multicentric retrospective observational study of consecutive minor stroke patients (National Institutes of Health Stroke Scale score ≤5) with basilar artery occlusion intended for IVT alone or bridging therapy. Propensity-score weighting was used to reduce baseline between-groups differences, and residual imbalance was addressed through adjusted logistic regression, with excellent outcome (3-month modified Rankin Scale score 0–1) as the dependent variable.

Results:

Fifty-seven patients were included (28 and 29 in the bridging therapy and IVT alone groups, respectively). Following propensity-score weighting, the distribution of baseline clinical and radiological variables was similar across the 2 patient groups, except age, posterior circulation Alberta Stroke Program Early CT Score, history of hypertension and smoking, and onset-to-IVT time. Compared with IVT alone, bridging therapy was associated with excellent outcome (adjusted odds ratio=3.37 [95% CI, 1.13–10.03];
P
=0.03). No patient experienced symptomatic intracranial hemorrhage.

Conclusions:
Our results suggest that bridging therapy may be superior to IVT alone in minor stroke with basilar artery occlusion.