bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burnout and associated factors among nurses working in public hospitals of Harari region and Dire Dawa administration, eastern Ethiopia. A cross sectional study
Authors: Dechasa Deribe Bekele , Worku Teshager , Baraki Negga , Merga Bedasa Taye , Asfaw Henock 
Published: October 2021

Background
Burnout is a syndrome of emotional exhaustion, low personal accomplishment and depersonalization experienced by a health professional and it is more common in nurses due to high workload and job stress that is mostly caused by working proximity to patients and taking care of them. Burnout compromises the provision of quality health care. Despite this, there is no information in Ethiopia on burnout among nurses in study area.

Objectives
To determine the magnitude of burnout and associated factors among nurses working in public hospitals of Harari regional state and Dire Dawa administration, eastern Ethiopia, February 1–29, 2020.

Methods
Institutional based quantitative cross-sectional study was employed from February 1–29 among 412 randomly selected nurses who have been working in hospitals for the last 6 months. Simple random sampling method was employed and data was collected by self-administered, standardized, reliable and valid, questionnaire (Maslachs Burnout Inventory- Human Services Survey). Data was entered into EpiData Version 3.1 and exported to statistical package for social science version 20 for analysis. All covariate with P-value less than 0.25 in bivariable analysis were candidate for multivariable analysis. Level of statistical significance was declared at p-value < 0.05.

Results
Among 412 nurses taking part in this study, 183(44.4%) of nurses with 95% CI, had experienced burnout. Married marital status [AOR:2.3,95%CI:(1.2–4.3)], poor current health status [AOR:4.8, 95% CI:(1.1–21.4)] and fair current health status [AOR:12, 95% CI:(4.5–32)], working greater than eight hour per-day[AOR:0.52, 95%CI:(0.29–0.92)], intention to leave a job [AOR:0.48,95%CI:(0.2–0.88), being working in emergency room [AOR:0.3,95%CI:(0.1–0.98)] and using a different medication related to work related health problems were factors associated with nurses’ burnout.

Conclusion
The nurses’ burnout in this study is high and it is attributed by marriage, perceiving health status as poor and fair, whereas, having the intention to leave job, being working in emergency room and using a medication in relation to work related health problems reduced risk of developing burnout. So, the concerned bodies should provide trainings which focus on stress copying mechanisms and assertiveness program.
Impact of persistent D-dimer elevation following recovery from COVID-19
Authors: Lehmann Antje , Prosch Helmut , Zehetmayer Sonja , Gysan Maximilian Robert , Bernitzky Dominik , Vonbank Karin , Idzko Marco , Gompelmann Daniela 
Published: October 2021

Background
Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia.

Objectives
To evaluate the rate of persistent elevated D-dimer and its association with thromboembolic complications and persistent ground glass opacities (GGO) after recovery from COVID-19.

Methods
In this post hoc analysis of a prospective multicenter trial, patients underwent blood sampling, measurement of diffusion capacity, blood gas analysis, and multidetector computed tomography (MDCT) scan following COVID-19. In case of increased D-dimer (>0,5 μg/ml), an additional contrast medium-enhanced CT was performed in absence of contraindications. Results were compared between patients with persistent D-dimer elevation and patients with normal D-dimer level.

Results
129 patients (median age 48.8 years; range 19–91 years) underwent D-Dimer assessment after a median (IQR) of 94 days (64–130) following COVID-19. D-dimer elevation was found in 15% (19/129) and was significantly more common in patients who had experienced a severe SARS-CoV2 infection that had required hospitalisation compared to patients with mild disease (p = 0.049). Contrast-medium CT (n = 15) revealed an acute pulmonary embolism in one patient and CTEPH in another patient. A significant lower mean pO2 (p = 0.015) and AaDO2 (p = 0.043) were observed in patients with persistent D-Dimer elevation, but the rate of GGO were similar in both patient groups (p = 0.33).

Conclusion
In 15% of the patients recovered from COVID-19, persistent D-dimer elevation was observed after a median of 3 months following COVID-19. These patients had experienced a more severe COVID and still presented more frequently a lower mean pO2 and AaDO2.
Daily television exposure, parent conversation during shared television viewing and socioeconomic status: Associations with curiosity at kindergarten
Authors: Shah Prachi E. , Hirsh-Pasek Kathy , Kashdan Todd B. , Harrison Kristen , Rosenblum Katherine , Weeks Heidi M. , Singh Priya , Kaciroti Niko 
Published: October 2021

Objective
To examine the main and interactive effects of the amount of daily television exposure and frequency of parent conversation during shared television viewing on parent ratings of curiosity at kindergarten, and to test for moderation by socioeconomic status (SES).

Study design
Sample included 5100 children from the Early Childhood Longitudinal Study, Birth Cohort. Hours of daily television exposure and frequency of parent screen-time conversation were assessed from a parent interview at preschool, and the outcome of early childhood curiosity was derived from a child behavior questionnaire at kindergarten. Multivariate linear regression examined the main and interactive effects of television exposure and parent screen-time conversation on kindergarten curiosity and tested for moderation by SES.

Results
In adjusted models, greater number of hours of daily television viewing at preschool was associated with lower curiosity at kindergarten (B = -0.14, p = .008). More frequent parent conversation during shared screen-time was associated with higher parent-reported curiosity at kindergarten with evidence of moderation by SES. The magnitude of association between frequency of parent conversation during television viewing and curiosity was greater for children from low SES environments, compared to children from high SES environments: (SES ≤ median): B = 0.29, p < .001; (SES > median): B = 0.11, p < .001.

Conclusions
Higher curiosity at kindergarten was associated with greater frequency of parent conversation during shared television viewing, with a greater magnitude of association in low-SES families. While the study could not include measures of television program content, digital media use and non-screen time conversation, our results suggest the importance of parent conversation to promote early childhood curiosity, especially for children with socioeconomic disadvantage.
Cardiovascular biomarkers as predictors of adverse outcomes in chronic Chagas cardiomyopathy
Authors: Echeverría Luis E. , Rojas Lyda Z. , Gómez-Ochoa Sergio Alejandro , Rueda-Ochoa Oscar L. , Sosa-Vesga Cristian David , Muka Taulant , Januzzi James L. , Marcus Rachel , Morillo Carlos A. 
Published: October 2021

Background
Chronic Chagas Cardiomyopathy (CCM) is a unique form of cardiomyopathy compared to other etiologies of heart failure. In CCM, risk prediction based on biomarkers has not been well-studied. We assessed the prognostic value of a biomarker panel to predict a composite outcome (CO), including the need for heart transplantation, use of left ventricular assist devices, and mortality.

Methods
Prospective cohort study of 100 adults with different stages of CCM. Serum concentrations of amino-terminal pro-B type natriuretic peptide (NT-proBNP), galectin-3 (Gal-3), neutrophil gelatinase-associated lipocalin (NGAL), high sensitivity troponin T (hs-cTnT), soluble (sST2), and cystatin-C (Cys-c) were measured. Survival analyses were performed using Cox proportional hazard models.

Results
During a median follow-up of 52 months, the mortality rate was 20%, while the CO was observed in 25% of the patients. Four biomarkers (NT-proBNP, hs-cTnT, sST2, and Cys-C) were associated with the CO; concentrations of NT-proBNP and hs-cTnT were associated with the highest AUC (85.1 and 85.8, respectively). Combining these two biomarkers above their selected cut-off values significantly increased risk for the CO (HR 3.18; 95%CI 1.31–7.79). No events were reported in the patients in whom the two biomarkers were under the cut-off values, and when both levels were above cut-off values, the CO was observed in 60.71%.

Conclusion
The combination of NT-proBNP and hs-TnT above their selected cut-off values is associated with a 3-fold increase in the risk of the composite outcome among CCM patients. The use of cardiac biomarkers may improve prognostic evaluation of patients with CCM.
The contribution of the proximity of the retinal detachment to the fovea for postoperative metamorphopsia after 27-gauge pars plana vitrectomy for the primary rhegmatogenous retinal detachment
Authors: Yamada Hiroko , Imai Hisanori , Tetsumoto Akira , Hayashida Mayuka , Otsuka Keiko , Miki Akiko , Nakamura Makoto 
Published: October 2021

Purpose
To investigate clinical factors contributing to metamorphopsia after 27-gauge pars plana vitrectomy (27GPPV) for primary rhegmatogenous retinal detachment (RRD) to reveal whether the proximity of the preoperative retinal detachment to the fovea is associated with postoperative metamorphopsia.

Methods
We retrospectively reviewed medical records of 77 eyes of 77 patients after 27GPPV for RRD. Patients were subdivided into three groups using optical coherence tomography findings: Group A, patients with RRD outside the vascular arcade; Group B, patients whose condition was present within the vascular arcade, but without foveal detachment; and Group C, patients with foveal detachment.

Results
The average metamorphopsia score (°) assessed with M-charts 12 months after surgery was 0.01 ± 0.04 in Group A (24 eyes), 0.08 ± 0.18 in Group B (20 eyes), and 0.49 ± 0.48 in Group C (33 eyes) (p<0.001). Logistic regression analysis revealed that metamorphopsia at 12 months after surgery significantly correlated with the proximity of the retinal detachment to the fovea (p = 0.007).

Conclusion
Metamorphopsia after 27GPPV for RRD correlated with the proximity of the preoperative retinal detachment to the fovea. Attention should be paid to the possibility of postoperative metamorphopsia development when retinal detachment is present within a vascular arcade even if the fovea is not involved.
Heart-rate-variability (HRV), predicts outcomes in COVID-19
Authors: Mol Maartje B. A. , Strous Maud T. A. , van Osch Frits H. M. , Vogelaar F. Jeroen , Barten Dennis G. , Farchi Moshe , Foudraine Norbert A. , Gidron Yori 
Published: October 2021

Background
Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe illness and death. Whilst previous studies have clarified these and several other aspects of COVID-19, one of the ongoing challenges regarding COVID-19 is to determine which patients are at risk of adverse outcomes of COVID-19 infection. It is hypothesized that this is the result of insufficient inhibition of the immune response, with the vagus nerve being an important neuro-immuno-modulator of inflammation. Vagus nerve activity can be non-invasively indexed by heart-rate-variability (HRV). Therefore, we aimed to assess the prognostic value of HRV, as a surrogate marker for vagus nerve activity, in predicting mortality and intensive care unit (ICU) referral, in patients hospitalized with COVID-19.

Methods
A retrospective cohort study including all consecutive patients (n = 271) diagnosed and hospitalized with COVID-19 between March 2020 and May 2020, without a history of cardiac arrhythmias (including atrial and ventricular premature contractions), pacemaker, or current bradycardia (heart rate <50 bpm) or tachycardia (heart rate >110 bpm). HRV was based on one 10s ECG recorded at admission. 3-week survival and ICU referral were examined.

Results
HRV indexed as standard deviation of normal to normal heartbeat intervals (SDNN) predicted survival (H.R. = 0.53 95%CI: 0.31–0.92). This protective role was observed only in patients aged 70 years and older, not in younger patients. HRV below median value also predicted ICU referral within the first week of hospitalization (H.R = 0.51, 95%CI: 0.29–0.90, P = 0.021).

Conclusion
Higher HRV predicts greater chances of survival, especially in patients aged 70 years and older with COVID-19, independent of major prognostic factors. Low HRV predicts ICU indication and admission in the first week after hospitalization.
Staying informed without a cost: No effect of positive news media on stress reactivity, memory and affect in young adults
Authors: Longpré Charlotte , Sauvageau Claudia , Cernik Rebecca , Journault Audrey-Ann , Marin Marie-France , Lupien Sonia 
Published: October 2021

Introduction
We read, see and hear news from various media sources every day. A large majority of the news is negative. A previous study from our laboratory showed that reading negative news is associated with both increased stress reactivity (measured via the stress hormone cortisol) and recall of the negative news segments in women.

Objectives
The present study investigated the effects of positive news on cortisol stress reactivity, memory and affect using a methodology highly similar to the study on negative news that was previously used by our team.

Methods
Sixty-two healthy participants aged between 18 and 35 years (81% women) were randomly exposed to either positive or neutral news segments, followed by a laboratory stressor. We assessed participants’ affect three times during the procedure and measured cortisol in saliva eight times (at 10-minute intervals). Twenty-four hours later, participants were contacted by phone to assess their recall of the news segments.

Results
Results showed that exposure to positive news, relative to neutral news, did not modulate participants’ cortisol levels in response to the laboratory stressor. Positive news had no impact on memory recall of the news and did not change participants’ positive or negative affect. Bayes factors suggested that these nonsignificant results are not attributable to low statistical power.

Conclusion
Contrary to negative news, positive and neutral news do not modulate stress reactivity, memory and affect. These results suggest that people can stay informed without physiological and psychological costs when the news to which they are exposed adopt a positive or neutral approach.
A novel paclitaxel coated balloon with increased drug transfer for treatment of complex vascular lesions
Authors: Gemeinhardt Ole , Schnorr Beatrix , Speck Ulrich , Scheller Bruno 
Published: October 2021

Background
Drug coated balloons (DCB) with paclitaxel (Ptx) dose of 2–3.5 μg/mm2 balloon surface inhibit restenosis with different effectiveness and duration of success. A clinical dose finding study is not known for any of the currently marketed products. The aim of the present preclinical trial was to investigate a novel DCB coated with 6 μg Ptx/mm2 in a porcine model.

Methods and results
The current study investigated a DCB with a novel, modified iopromide based matrix with 6 μg Ptx/mm2. Drug transfer to the vessel wall of peripheral arteries was compared with a dose of 3 μg Ptx/mm2 and two fully overlapping DCB with 3 μg Ptx/mm2, each.
Ptx concentration in the vessel wall after drug transfer was about twice as high for balloons with 6 μg/mm2 (1957±1472 μg/g) and two overlapping DCB with 3 μg Ptx/mm2, each (1287±619 μg/g) compared to a single balloon with 3 μg Ptx/mm2, (787±738 μg/g), with statistical significant differences for 1x6 μg/mm2 vs. 1x3 μg/mm2 (p = 0.017) but not for 2x3 μg/mm2 vs. 1x3 μg/mm2 (p = 0.184) and 1x6 μg/mm2 vs. 2x3 μg/mm2 (p = 0.178). The proportion of residual Ptx on balloon after treatment was similar for all groups between 6±1% and 10±3% of dose on balloon.

Conclusion
The dose of 6 μg Ptx/mm2 was successfully as well as reproducibly coated on conventional balloon catheters. Increased Ptx on balloons resulted in increased drug concentration in the vessel wall. A single balloon with 6 μg Ptx/mm2 seems to provide double dose compared to 3 μg Ptx/mm2, facilitates the procedure, and may reduce medico-economic cost compared to the use of two standard DCB.
Is BMI associated with anemia and hemoglobin level of women and children in Bangladesh: A study with multiple statistical approaches
Authors: Kamruzzaman Md 
Published: October 2021

Background
The coexistence of undernutrition and obesity is an emerging problem for developing countries like Bangladesh. Anemia is another critical public health threat, prevalent predominantly among women and children. Undernutrition is linked with a higher risk of anemia, and lower dietary iron intake might be the possible reason. However, the risk of anemia among obese/overweight individuals is controversial. The study explores the relation of BMI with anemia and blood hemoglobin level among women and children in Bangladesh.

Methods
Multiple statistical approaches were employed to nationally representative secondary data (BDHS 2011) on women (n = 5680) age 15–49 years and children (n = 2373) age 6–59 months to illuminate the relation between BMI and anemia. BMI was categorized according to the WHO recommended BMI category for Asian people. Descriptive statistics were used to measure mean hemoglobin level. Chi-square test, Pearson correlation, Two-way ANOVA, binary, ordinal, and restricted cubic splines (RCS) regression were used to study the association of BMI with anemia and hemoglobin level.

Results
Chi-square test reveals significant association, though not intense, among BMI and anemia categories of women (15–49 years) (χ2 ≥99, p<2.2e-16 and Cramér’s V = 0.0799–0.1357). From ANOVA analysis, a significant difference in blood hemoglobin level was found among women (total sample and nonpregnant) with different BMI categories (p≤0.05). Binary (Severely Underweight: OR 1.2680, 95% CI 0.755–2.161; Obese: OR 0.4038, 95% CI 0.120–1.177), Ordinal logistic regression (Severely Underweight: OR 1.337, 95% CI 0.842–2.115; Obese: OR 0.504, 95% CI 0.153–1.411) and restricted cubic spline regression (Severely Underweight: OR >1.5; Obese: OR ~0.5) reveal that the risk of anemia was higher among underweight and lower among obese/overweight women compared to normal women. Lower anemia risk among richest women indicates probable higher dietary iron intake among obese/overweight women.

Conclusion
In the current study, women with overweight/obesity from Bangladesh were shown to have lower likelihood of being anemic, while underweight women more likely to be anemic. However, no relation between BMI and anemia was found among children.
Compression of medical images by quaternionic wavelet transform
Authors: Ledoux Ebassa Eloundou Bertrand , Joseph Oyobe  Okassa AimÃ© , Ndongo Abena HervÃ© , ELE Pierre 
Published: October 2021

Technological developments for several years have resulted in the handling (storing, exchanging or processing) of increasingly important data in various fields and particularly in medical field. In this works we present a new image compression / decompression algorithm based on the quaternion wavelet transform (QWT). This algorithm is simple, fast and efficient. It has been applied to medical images. The results obtained after decompression are appreciated through the compression parameter values of CR, PSNR, and MSE and by visual observation. By the values of these parameters, the results of the algorithm are considered encouraging.Â Â
Diagnosis of Medical Images Using Cloud-Deep Learning System
Authors: Jacobs Michael , Arfan Ali , Sheta Alaa 
Published: October 2021

Diagnosis of brain tumors is one of the most severe medical problems that affect thousands of people each year in the United States. Manual classification of cancerous tumors through examination of MRI images is a difficult task even for trained professionals. It is an error-prone procedure that is dependent on the experience of the radiologist. Brain tumors, in particular, have a high level of complexity.Â Therefore, computer-aided diagnosis systems designed to assist with this task are of specific interest for physicians. Accurate detection and classification of brain tumors via magnetic resonance imaging (MRI) examination is a famous approach to analyze MRI images. This paper proposes a method to classify different brain tumors using a Convolutional Neural Network (CNN). We explore the performance of several CNN architectures and examine if decreasing the input image resolution affects the model's accuracy. The dataset used to train the model has initially been 3064 MRI scans. We augmented the data set to 8544 MRI scans to balance the available classes of images. The results show that the design of a suitable CNN architecture can significantly better diagnose medical images. The developed model classification performance was up to 97\% accuracy.
Development and validation of the questionnaire on EFL students’ perceptions of authorial stance in academic writing
Authors: Zhang Lu , Zhang Lawrence Jun 
Published: October 2021

AbstractStudies on academic writing of EFL students have found that they have been less successful in presenting an effective stance. It has been assumed that how they perceive authorial stance may influence their stance deployment. Yet few studies have been conducted to assess student writers’ perceptions of stance. To fill the gap, this research intends to develop and validate an instrument, thePerceptions of Authorial Stance Questionnaire(PASQ), for assessing EFL students’ perceptions of authorial stance and further exploring their relationships with stance deployment and the overall quality of English academic writing. Taking a dialogic perspective, we designed the research with two studies in it. In Study 1, exploratory factor analysis with 197 respondents and subsequent confirmatory factor analysis with another sample of 191 respondents produced results of a 17 item scale with two-factors: dialogic contraction and dialogic expansion. In Study 2, scores for the two subscales of the PASQ were examined in relation to the frequencies of various stance types and writing scores. Results show that scores for the two subscales of perceptions were positively correlated with the frequencies of different stance types. However, no significant relationship was detected between students’ perceptions and their writing scores. Possible reasons of the findings and their pedagogical implications are discussed.
On the torsion values for sections of an elliptic scheme
Authors: Corvaja Pietro , Demeio Julian , Masser David , Zannier Umberto 
Published: October 2021

Abstract
We shall consider sections of a complex elliptic scheme

ℰ

{{{\mathcal{E}}}}

over an affine base curve B, and study the points of B where the section takes a torsion value. In particular, we shall relate the distribution in B of these points with the canonical height of the section, proving an integral formula involving a measure on B coming from the so-called Betti map of the section. We shall show that this measure is the same one which appears in dynamical issues related to the section.
This analysis will also involve the multiplicity with which a torsion value is attained, which is an independent problem. We shall prove finiteness theorems for the points where the multiplicity is higher than expected. Such multiplicity has also a relation with Diophantine Approximation and quasi-integral points on

ℰ

{{{\mathcal{E}}}}

(over the affine ring of B), and in Sections 5 and 6 of the paper we shall exploit this viewpoint, proving an effective result in the spirit of Siegel’s theorem on integral points.