bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Remodeling and Disease Progression in Patients With Repaired Coarctation of Aorta and Aortic Stenosis
Authors: Egbe Alexander C. , Oh Jae K. , Pellikka Patricia A. 
Published: December 2021

Background:
Valvulo-arterial impedance (Zva) is used for assessment of left ventricular (LV) global pressure load in patients with aortic stenosis (AS) and impaired arterial compliance. Because patients with repaired coarctation of aorta (COA) have impaired arterial compliance, we hypothesized that COA patients with greater than or equal to moderate AS (AS-COA group) will have higher Zva, symptomatic progression, and cardiovascular events, as compared to non-COA patients with similar AS severity (AS group).

Methods:
Propensity matching (1:1) of 71 AS-COA and 71 AS patients based on age, sex, body mass index, and aortic valve mean gradient (cohort 1). Of 172 patients, 117 patients (AS-COA [n=62]; AS [n=55]) underwent aortic valve replacement, cohort 2. Cohort 1 was used to assess the relationship between preoperative Zva, cardiac remodeling, and symptomatic progression, while cohort 2 was used to assess the relationship between postoperative Zva, LV mass index regression (reduction in LV mass index after aortic valve replacement), and cardiovascular events.

Results:

The AS-COA group had higher Zva (4.2±0.6 versus 3.5±0.4 mm Hg/mL·m
2
,
P
<0.001), more advanced cardiac remodeling, and higher 5-year incidence of symptomatic progression (85% versus 51%,
P
<0.001). Preoperative Zva was independently associated with cardiac remodeling (r=0.66,
P
<0.001) and symptomatic progression (hazard ratio, 1.06 [1.02–1.10], per mm Hg/mL·m
2
increase in Zva).

The AS-COA group had higher postoperative Zva (3.3±0.5 versus 2.4±0.4 mm Hg/mL·m
2
,
P
<0.001), less robust LV mass index regression at 1-year post–aortic valve replacement, and higher 5-year incidence of cardiovascular events. Postoperative Zva was independently associated with LV mass index regression (r=−0.46,
P
<0.001) and cardiovascular events (hazard ratio, 1.06 [1.02–1.10], per mm Hg/mL·m
2
increase in Zva).

Conclusions:
Adults with AS-COA had higher LV global pressure load, cardiac remodeling, symptomatic progression, and cardiovascular events as compared to non-COA patients with similar severity of AS. Zva can identify patients at risk for adverse outcomes, and perhaps should be used for risk stratification with regards to timing of aortic valve replacement.
Canadian Multicenter Chronic Total Occlusion Registry: Ten-Year Follow-Up Results of Chronic Total Occlusion Revascularization
Authors: Strauss Bradley H. , Knudtson Merril L. , Cheema Asim N. , Galbraith P. Diane , Elbaz-Greener Gabby , Abuzeid Wael , Henning Kayley A. , Qiu Feng , Wijeysundera Harindra C. 
Published: December 2021

Background:
Chronic total occlusions (CTO) occur in nearly 20% of coronary angiograms. CTO revascularization, either by percutaneous coronary intervention (PCI) or coronary artery bypass grafting surgery (CABG), is infrequently performed, approximately one-third of cases. Long-term outcomes are unknown. The objective of the study was to determine whether early CTO revascularization of patients, either by CABG or PCI, was associated with improved clinical outcomes.

Methods:
One thousand six hundred twenty-four patients from the Canadian CTO registry were followed for at least 9.75 years. Revascularization was performed according to routine clinical practice. Patients were grouped according to CTO revascularization status (PCI or CABG of CTO vessel, CTO revasc) or no CTO revasc (medical therapy only, or PCI/CABG of non-CTO vessels only), within 3 months of initial angiogram. Patients were followed for mortality, revascularization procedures (PCI and CABG), and hospitalizations for acute coronary syndromes and heart failure.

Results:
Early CTO revasc was performed in 28.2% of patients (17.5% CABG, 10.7% PCI). The CTO revasc group was younger, with more males and generally fewer comorbidities. There was a significantly lower mortality probability at 10 years in the CTO revascularization group (22.7% [95% CI, 19.0%–26.9%]) compared with the no CTO revasc group (36.6% [95% CI, 33.8%–39.5%]). At 10 years, revascularization rates (14.0% versus 22.8%) and acute coronary syndrome hospitalization rates (10.0% versus 16.6%) were significantly lower in the CTO revasc group. Baseline-adjusted analysis showed CTO revasc was associated with significantly lower all-cause mortality (hazard ratio, 0.67 [95% CI, 0.54–0.84]). In both landmark and time varying analyses, association with lower mortality was particularly robust for CTO revascularization by CABG (hazard ratio 0.56 and 0.60, respectively), with a marginally significant result for PCI in the time varying analysis (hazard ratio 0.711 [95% CI, 0.51–0.998]).

Conclusions:
Early CTO revascularization was associated with significantly lower all-cause mortality, revascularization rates, and hospitalization for acute coronary syndrome at 10 years, and mainly driven by outcomes in patients with CABG.
Connectomic analysis of Alzheimer’s disease using percolation
theory
Authors: Kotlarz Parker , Nino Juan C. , Febo Marcelo 
Published: December 2021

Abstract
Alzheimer’s disease (AD) is a severe neurodegenerative disorder that affects a growing worldwide elderly population. Identification of brain functional biomarkers is expected to help determine preclinical stages for targeted mechanistic studies and development of therapeutic interventions to deter disease progression. Connectomic analysis, a graph theory–based methodology used in the analysis of brain-derived connectivity matrices was used in conjunction with percolation theory targeted attack model to investigate the network effects of AD-related amyloid deposition. We used matrices derived from resting-state functional magnetic resonance imaging collected on mice with extracellular amyloidosis (TgCRND8 mice, n = 17) and control littermates (n = 17). Global, nodal, spatial, and percolation-based analysis was performed comparing AD and control mice. These data indicate a short-term compensatory response to neurodegeneration in the AD brain via a strongly connected core network with highly vulnerable or disconnected hubs. Targeted attacks demonstrated a greater vulnerability of AD brains to all types of attacks and identified progression models to mimic AD brain functional connectivity through betweenness centrality and collective influence metrics. Furthermore, both spatial analysis and percolation theory identified a key disconnect between the anterior brain of the AD mice to the rest of the brain network.
Serpent Handling: Toward a Cognitive Account – Honoring the Scholarship of Ralph W. Hood Jr.
Authors: Coleman Thomas J. , Silver Christopher F. , Jong Jonathan 
Published: December 2021

Abstract
The ritual handling of serpents remains an unnoticed cultural form for the explanatory aims and theoretical insights desired by cognitive scientists of religion. In the current article, we introduce the Hood and Williams archives at The University of Tennessee at Chattanooga that contains data culled from Hood’s 40-plus year career of studying serpent handlers. The archives contain hundreds of hours of interviews and recordings of speaking in tongues, handling fire, drinking poison, and taking up serpents by different congregants and congregations. The archive remains a rich but untapped source of data for building, testing, and refining cognitive theories of ritual in general, and serpent handling in specific. We connect Hood’s work to current cognitive theories and engage critically with research on the social functions of ritual. Finally, we discuss several further reasons to pay more attention to SHS communities and practices in cognitive theories of ritual.
The “Catholic” Church in Socrates of Constantinople and Pacian of Barcelona
Authors: Whiting Colin. M. 
Published: December 2021

Abstract
While this article does not presume to answer the old question “Was Socrates of Constantinople a Novatian?”, it does offer a hitherto-unnoticed observation that may bear on the question. Socrates, as has been noted, is very reticent to use the term “catholic” in describing the church in his Historia ecclesiastica. This is unlikely to be a stylistic quirk, as a comparison to the history of Sozomen shows. No one yet has connected his reticence to the Novatian Sympronian, who objects to the same term on theological grounds in letters exchanged with Pacian of Barcelona. Given Socrates’ reluctance to use the term and Novatian’s rejection of the same term, we may well have more evidence suggesting that Socrates was at the very least sympathetic not only to Novatians as a community but to their theological positions as well. In any case, the resistance of both Sympronian and Socrates to the notion of a “catholic” church stands in contrast to the usual interpretation of late antiquity as a period of growing universalism. The article also discusses whether it is even valid to ask whether Socrates was a Novatian or whether this question falls into less useful confessional dichotomies.
A New Family to the ANOC Groups: A Study of Stelae CG 20077 and CG 20098
Authors: Rosell Pablo M. 
Published: December 2021

Abstract
The Middle Kingdom stelae found at Abydos are some of the most important sources of information to analyze and reconstruct Egyptian society. This article aims at providing a study and translation of two Middle Kingdom stelae that are preserved in the Grand Egyptian Museum in Giza and in the Egyptian Museum in Cairo. They are stela CG 20077, which belongs to an individual called Nemtu, and stela CG 20098, which belongs to a man called Nemtyemmer. The family relations attested in both stelae suggest that they could be part of the same family group and consequently constitute a new Abydos North Offering Chapel (ANOC). This paper also offers an analysis of the ANOC and proposes that these stelae should be added to the ANOC groups. Lastly, we attempt to identify the social identities represented in both stelae and the possible social and geographical origin of this family.
從浙江江山長汀話探究長汀中部與南部客家話的類型差異
Authors: 吳 中杰 , 張 學年 
Published: December 2021

摘要
唐末入居福建長汀宣成，北宋中期遷到同縣的戴坊，清初又從戴坊搬到浙江江山廿八都鎮的戴氏移民所操之客家話，究竟在哪些方面保留宣成特色？哪些又是戴坊成分？受到通用於廿八都鎮當地的正話如何的影響？受更大範圍通行的吳語如何的左右？是否有上述因素之外的存古現象或自行演變？本文逐一剖析，以期了解江山長汀話的固有及外來層次、乃至語言演變歷史。以中古音系為間架，記錄長汀三洲鎮戴坊村、宣成鄉藍田村的語料，著重彼等在聲母、韻母、聲調的區別，進而觀察江山長汀話的各種組成部分。援用陳忠敏（2007）的工作方法，來離析出江山長汀話的固有及外來層次，而非推究原始客家話在語音上的出發點；且對於系統性的常規、和個別的非常規語音對應訊息同等重視。此研究經驗顯示，如欲探究特定地點的語言（江山長汀話）演變歷程，要先將在地強勢語言（正話、吳語）造成的影響成分先剔除出來，因為這屬於表層現象。其次和移民原鄉語言比對，有可能超過一種以上（宣成、三洲），因此非常複雜。最後才能確定不是來自原鄉和在地強勢語言的獨特存古或自行演變成分。調查結果能呼應何純惠（2014）紀錄，證明長汀中部與南部客家話，確實各有其特點，韻母、聲調上都具有明顯的類型差異。
Մեսրոպ Մաշտոցի անուան Մատենադարանի 2020 թուականի հրատարակութիունները
Authors: Hambardzumyan (Հայկ Համբարձումյան) Hayk 
Published: December 2021

Ամփոփում
Երևանի Մեսրոպ Մաշտոցի անուան Մատենադարանը իր գիտակրթական ու թանգարանային գործունէութեանը զուգահեռ իրականացնում է նաև հրատարակչական աշխատանքներ: Մատենադարանում հրատարակութեան պատրաստուող գրքերը ընդգրկում են հումանիտար գիտութիւնների գրեթէ բոլոր ոլորտները՝ պատմագիտութիւն, միջնադարագիտութիւն, հայագիտութիւն, արուեստագիտութիւն, ձեռագրագիտութիւն, գրականագիտութիւն, եւ այլն։ Այս յօդուածը կ՚ամփոփէ 2020 տարուայ տպագրուած այն գիրքերը։ 2020 թուականին և նախորդ տարիներին Մատենադարանում հրատարակուած գրքերի թուային տարբերակները կարելի է ընթերցել www.matenadaran.am կայքի « Թվային գրադարան » բաժնում:
Role of Upwind Precipitation in Transboundary Pollution and Secondary Aerosol Formation: A Case Study during the KORUS-AQ Field Campaign
Authors: Ryu Young-Hee , Min Seung-Ki , Knote Christoph 
Published: December 2021

Abstract
Clouds and precipitation play critical roles in wet removal of aerosols and soluble gases in the atmosphere, and hence their accurate prediction largely influences accurate prediction of air pollutants. In this study, the impacts of clouds and precipitation on wet scavenging and long-range transboundary transport of pollutants are examined during the 2016 Korea–United States Air Quality (KORUS-AQ) field campaign using the Weather Research and Forecasting Model coupled with chemistry. Two simulations—one in which atmospheric moisture is constrained and one in which it is not—are performed and evaluated against surface and airborne observations. The simulation with moisture constraints is found to better reproduce precipitation as well as surface PM2.5, whereas the areal extent and amount of precipitation are overpredicted in the simulation without moisture constraints. As a results of overpredicted clouds and precipitation and consequently overpredicted wet scavenging, PM2.5 concentration is generally underpredicted across the model domain in the simulation without moisture constraints. The effects are significant not only in the precipitating region (upwind region, southern China in this study) but also in the downwind region (South Korea) where no precipitation is observed. The difference in upwind precipitation by 77% on average between the two simulations leads to the difference in PM2.5 by ∼39% both in the upwind and downwind regions. The transboundary transport of aerosol precursors, especially nitric acid, has a considerable impact on ammonium-nitrate aerosol formation in the ammonia-rich downwind region. This study highlights that skillful prediction of atmospheric moisture can have ultimate potential to skillful prediction of aerosols across regions.
Using Nonlinear Kinematic Parameters as a Means of Predicting Motion Sickness in Real-Time in Virtual Environments
Authors: Smart L. James , Drew Anthony , Hadidon Tyler , Teaford Max , Bachmann Eric 
Published: December 2021

Objective This article presents two studies (one simulation and one pilot) that assess a custom computer algorithm designed to predict motion sickness in real-time. Background Virtual reality has a wide range of applications; however, many users experience visually induced motion sickness. Previous research has demonstrated that changes in kinematic (behavioral) parameters are predictive of motion sickness. However, there has not been research demonstrating that these measures can be utilized in real-time applications. Method Two studies were performed to assess an algorithm designed to predict motion sickness in real-time. Study 1 was a simulation study that used data from Smart et al. (2014). Study 2 employed the algorithm on 28 new participants’ motion while exposed to virtual motion. Results Study 1 revealed that the algorithm was able to classify motion sick participants with 100% accuracy. Study 2 revealed that the algorithm could predict if a participant would become motion sick with 57% accuracy. Conclusion The results of the present study suggest that the motion sickness prediction algorithm can predict if an individual will experience motion sickness but needs further refinement to improve performance. Application The algorithm could be used for a wide array of VR devices to predict likelihood of motion sickness with enough time to intervene.
A Cross-Sectional, Questionnaire-Based Study on Drug Treatment Awareness in Schizophrenia Patients and Caregivers: An Unexplored Avenue
Authors: Tripathi Raakhi , Jalgaonkar Sharmila , Gajbhiye Snehalata , Khatri Nishtha , Sayyed Mohsin , Parkar Shubhangi 
Published: December 2021

Background: Schizophrenia is associated with high relapse rates, and medication nonadherence is a major factor contributing toward relapse. Since medication adherence and treatment awareness are linked, an alarming need was felt to evaluate the level of drug treatment awareness in patients who have schizophrenia. Besides, patients who have schizophrenia are often dependent on their caregivers for medications. Hence, the current study was also designed to look into drug treatment awareness among caregivers. Methods: This was a cross-sectional, questionnaire-based study. Patients diagnosed with schizophrenia as per The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition were included, provided they had good insight and had been prescribed medications at the study center for at least three months. Caregivers were included using the Pollak and Perlick criteria. The sociodemographic profile of the patients and caregivers was recorded, and further assessment for treatment awareness was done using the prevalidated Drug Treatment Awareness Questionnaire (DTAQ). Results: A total of 166 patients and 157 caregivers were enrolled. Mean drug awareness scores among patients and caregivers did not show statistically significant differences (P= 0.22). Mean ± SD DTAQ awareness scores in patients and caregivers were 12.57 ± 1.81 and 12.84 ± 1.91, respectively. The majority of patients and caregivers (> 90%) possessed awareness in domains related to past medication records and in that of re-visit/re-contact instructions. Awareness was least commonly seen in relation to side effects of medications and details of the prescribed medications, where only about 50% of patients and caregivers possessed awareness. No clinically significant correlation was found between sociodemographic factors and drug treatment awareness scores. Conclusion: Drug treatment awareness in patients and caregivers was comparable and was not reliant on the sociodemographic factors. Special interventions should be conducted to raise drug treatment awareness among patients having insight and their caregivers.
Effectiveness of brief patient information materials for promoting correct beliefs about imaging and inevitable consequences of low back pain: A randomised controlled trial
Authors: Diniz Leandro M. , Oliveira Crystian B. , Machado Gustavo C. , Maher Christopher G. , Verhagen Arianne P. , Fernandes Daysiane A. M. , Franco Marcia R. , Souza Thales R. , Pinto Rafael Z. 
Published: December 2021

Objective To investigate what format for providing patient information (i.e. written summary, infographic or video animation) is most effective for promoting correct beliefs about imaging and inevitable consequences of low back pain (LBP). Design Randomised controlled trial. Setting/Patients One hundred and fifty-nine patients with non-specific LBP were recruited from outpatient physiotherapy clinics. Intervention Participants were randomised to receive patient information in one of three formats: video animation, infographic or written summary. Patients were allowed to read or watch the materials for up to 20 min. Measurements Outcome were assessed before and immediately after the intervention. The primary outcome was the Back Beliefs Questionnaire. The secondary outcome was beliefs about imaging for LBP assessed by two questions. Results All 159 patients completed the study. Our findings revealed no difference between groups for the Back Beliefs Questionnaire. Correct beliefs about imaging were more likely with the infographic than the video animation (Question 1- Odds Ratio [OR] = 3.9, 95% confidence interval [CI]: 1.7, 8.7; Question 2- OR = 6.8, 95%CI: 2.7, 17.2) and more likely with the written summary than the video animation (Question 1- OR = 3.3, 95%CI: 1.5, 7.4; Question 2- OR = 3.7, 95%CI: 1.6, 8.5). No difference between infographic and written summary formats were reported for the questions assessing LBP imaging beliefs. Conclusion The three materials were equally effective in improving patient's general beliefs about LBP care. However, the traditional written summary or infographic formats were more effective than the video animation format for improving beliefs about imaging for LBP.
Retrospective evaluation of sodium acetate use for urine alkalinization in patients receiving high dose methotrexate
Authors: Perkey Cassandra L , Flynn Laura A , Lentz Katie , Butler Sara 
Published: December 2021

Purpose Methotrexate is an antifolate agent used in treatment of several malignancies. Many toxicities accompany methotrexate that are minimized with urine alkalinization. Parenteral sodium bicarbonate is the historical standard alkalinizing agent, but use has been limited by intermittent shortages. However, intravenous sodium acetate may be considered as a chemically equivalent alternative. The primary objective of this study is to determine the efficacy of sodium acetate versus sodium bicarbonate for urine alkalinization for high-dose methotrexate (HDMTX). Methods This is a retrospective cohort study including adults admitted to Barnes-Jewish Hospital to receive HDMTX for lymphoma, breast cancer with leptomeningial spread, or osteosarcoma. Patients must have received intravenous sodium acetate or sodium bicarbonate alkalinization. Results Of 192 HDMTX encounters, 154 (sodium bicarbonate, n = 86; sodium acetate, n = 68) were evaluated for efficacy and safety. Safety outcomes were not significantly different between groups except for higher peak methotrexate level in the bicarbonate group (2.9 mcmol/L vs. 1.7 mcmol/L, p = 0.023), and increased incidence of grade 3–4 ALT in the sodium bicarbonate group (23.5% vs. 9%, p = 0.02). Time from alkalinizer initiation to pH ≥7 was significantly shorter with sodium bicarbonate (4 vs. 5.15 h, p = 0.021). Nonetheless, outcomes such as length of stay (4.4 vs. 4 days respectively, p = 0.037) and time to methotrexate clearance (3.6 vs. 3.2 days respectively, p = 0.023) reveal that inpatient time was shorter with sodium acetate overall. Conclusion This retrospective analysis suggests that sodium acetate has similar efficacy and safety to sodium bicarbonate for alkalinization and may be considered as an alternative in future shortage situations.
Evaluation of music therapy to reduce stress in hospitalized cats
Authors: Paz Juliane EG , da Costa Fernanda VA , Nunes Luciana N , Monteiro Eduardo R , Jung Jenifer 
Published: December 2021

Objectives This study aimed to evaluate the use of two different types of music – cat-specific music and classical music – compared with no music, to reduce stress in cats during hospitalization. Methods Thirty-five hospitalized cats were randomly divided into three groups and each group received a different stimulus – cat-specific music, classical music or no music (control) – throughout their hospitalization. Respiratory rate, salivary cortisol and social interaction were documented. A blinded researcher performed the Cat Stress Score (CSS) during the video analysis of recordings at five specific times over 31 h of hospitalization. Results There was no difference in the mean CSS between cats listening to cat-specific music, classical music and control throughout the five evaluations. Cat-specific music had a higher percentage of positive social interactions than the other groups on the first evaluation ( P <0.05). The average respiratory rate was significantly lower in the classical music group vs control on the fourth evaluation ( P <0.05). Although statistically insignificant, the average respiratory rate decreased only in the classical music group during the five evaluations. Cortisol quantification did not seem to follow the CSS results. However, owing to the low and unrepresentative number of samples, it was not possible to perform statistical analysis on these results or a group sample comparison. Conclusions and relevance Both cat-specific music and classical music seem to have some benefit to hospitalized cats. The salivary cortisol analysis was not adequate nor useful to measure stress in hospitalized cats in our study.