bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrence Beyond the Milan Criteria of HBV-Related Single Hepatocellular Carcinoma of 2–3 cm: Comparison of Resection and Ablation
Authors: Chen Shuanggang , Ma Weimei , Shen Lujun , Wu Ying , Qi Han , Cao Fei , Huang Tao , Fan Weijun 
Published: October 2021

BackgroundComparison of patterns of early hepatocellular carcinoma (HCC) recurrence beyond the Milan criteria (HRBM) and identification of the independent risk factors of time to recurrence beyond the Milan criteria (TRBM) after resection or ablation can develop an optimal first-line treatment and provide more opportunities and waiting time for salvage transplantation.MethodsThe patterns of HRBM after first-line resection or ablation in 384 patients with single-nodule HBV-associated HCC of 2–3 cm were retrospectively analyzed by one-to-one propensity score matching (PSM) between December 2008 and December 2017. The median TRBM between the resection group and the ablation group was estimated by Kaplan–Meier curves. The Cox regression analysis and binary logistic regression were used for the identification of the independent risk factors of TRBM and the occurrence of HRBM, respectively. The abilities of HRBM and the recurrence to predict overall survival (OS) were compared by the time-dependent receiver operating characteristic curves and estimated area under the curve.ResultsOf 384 patients enrolled in our study, 260 (67.7%) received resection (resection group) and 124 (32.3%) underwent ablation (ablation group). The median TRBM in the resection group was significantly longer than that in the ablation group before PSM (median, not available vs. 101.4 months, P &lt; 0.001) and after PSM (median, not available vs. 85.7 months, P &lt; 0.001). Cox regression showed ablation, older age, CRP ≥1.81 mg/L, and PLT ≤80 × 109/L were the independent risk factors of TRBM. Binary logistic regression also showed that ablation, CRP ≥1.81 mg/L, and PLT ≤80 × 109/L were the independent risk factors of the occurrence of HRBM. The incidences of various phenotypes of HRBM were not significantly different between the two groups, but the incidence of HRBM at the first recurrence in the ablation group was significantly higher than that in the resection group (P &lt; 0.05). Besides, compared with recurrence, HRBM was a better predictor of OS (P &lt; 0.05).ConclusionsCompared with ablation, resection should be considered as a more appropriate first-line option for patients with single-nodule HBV-associated HCC of 2–3 cm and a more promising bridge for liver transplantation in those patients.
Analysis of Clinical Characteristics and Risk Factors of Plastic Bronchitis in Children With Mycoplasma pneumoniae Pneumonia
Authors: Zhong Haiqin , Yin Rong , Zhao Ran , Jiang Kun , Sun Chao , Dong Xiaoyan 
Published: October 2021

Objective: To analyze the clinical characteristics of plastic bronchitis (PB) in children with Mycoplasma pneumoniae pneumonia (MPP) in order to explore its risk factors.Methods: A retrospective analysis was performed in MPP children receiving bronchoscopy admitted to department of respiratory medicine in Shanghai Children's Hospital from January 2018 to December 2020. According to the bronchoscopic findings, the patients were divided into PB group and non-PB group. The clinical manifestations, laboratory examination, etiology, treatment methods and outcomes of the children were analyzed. Logistic regression was used to analyze the risk factors for PB in children with MPP.Results: A total of 296 children with MPP were enrolled in the study, including 42 (14.2%) children in the PB group and 254 (85.8%) children in the non-PB group. There was no difference in the ratios of gender, age, proportion of fever, cough, wet rales, and wheezing rales between the two groups (P &gt; 0.05). The univariate analysis showed that there were significant differences between the PB group and the non-PB group in LDH, D-dimer, CD3+CD4+(%), CD3+CD4+/CD3+CD8+, CD3 count, CD4 count, CD8 count, complement 3, IL8, IL-1β, IL-2, IL-10 (P &lt; 0.05). The multivariate logistic regression analysis showed that fever duration &gt; 12 d, IL-8 &gt; 2,721.33 pg/ml, LDH &gt; 482 U/L and complement 3 &lt;1.02 g/L were independent risk factors for PB in children with MPP.Conclusions: Children with PB caused by MPP have protracted fever, a strong inflammatory response and immune function disturbance.
Prenatal Diagnosis of Holt–Oram Syndrome With a Novel Mutation of TBX5 Gene: A Case Report
Authors: He Guan-nan , Wang Xue-yan , Kang Min , Chen Xi-min , Xi Na , Zhao Jing , Chen Xi 
Published: October 2021

Background: Holt–Oram syndrome (HOS) is an autosomal dominant disorder caused by mutations of TBX5 gene.Case presentation: We report a fetus with HOS diagnosed sonographically at 23 weeks of gestation. The fetal parents are non-consanguineous. The fetus exhibited short radius and ulna, inability to supinate the hands, absence of the right thumb, and heart ventricular septal defect (VSD), while the fetal father exhibited VSD and short radius and ulna only. Fetal brother had cubitus valgus and thumb adduction, except for VSD, short radius and ulna. The pregnancy was terminated. Whole-exome sequencing (WES) revealed a novel mutation in the TBX5 (c.510+1G&gt;A) in the fetus inherited from the father. The variant (c.510+1G&gt;A) occurs at splice donor and may alter TBX5 gene function by impact on splicing. It was not previously reported in China.Conclusion: Our case reported a novel mutation in TBX5, which expanded the known genetic variants associated with HOS.
Non-Invasive Remote Ischemic Preconditioning May Protect the Gastric Mucosa Against Ischemia-Reperfusion-Induced Injury Through Involvement of Glucocorticoids
Authors: Filaretova Ludmila , Komkova Olga , Sudalina Maria , Yarushkina Natalia 
Published: October 2021

Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only on heart, but also on brain, lungs, kidneys, liver, intestine, and stomach. We previously demonstrated that glucocorticoids participate in protective effect of local gastric ischemic preconditioning against I/R-induced gastric injury. In the present study we investigated whether RIPC may protect the gastric mucosa against I/R-induced injury through involvement of glucocorticoids. Anesthetized fasted Sprague Dawley male rats were exposed to prolonged gastric I/R (30 min occlusion of celiac artery followed by 3 h of reperfusion) alone or with preliminary brief RIPC (10 min non-invasive occlusion of right hind limb blood flow followed by reperfusion for 30 min). First, we investigated the effect of RIPC on I/R-induced injury by itself. Then to study the role of glucocorticoids similar experiments were carried out: 1) in rats pretreated with the inhibitor of glucocorticoid synthesis, metyrapone (30 mg/kg, i.p), and in control animals; 2) in adrenalectomized rats without or with corticosterone replacement (4 mg/kg, s.c.) and in sham-operated animals; 3) in rats pretreated with glucocorticoid receptor antagonist RU-38486 (20 mg/kg, s.c.) and in control animals. I/R induced corticosterone rise and resulted in the gastric erosion formation. RIPC significantly reduced the erosion area in control animals. Metyrapone injected shortly before RIPC caused a decrease in plasma corticosterone levels and prevented the gastroprotective effect of RIPC and, moreover, further aggravated the deleterious effect of I/R. Adrenalectomy performed 1 week before experiment created long-lasting corticosterone deficiency and had no effect on the gastroprotective effect of RIPC. Nevertheless, corticosterone replacement which mimics the corticosterone rise, similar to RIPS, significantly reduced erosion areas of gastric mucosa in adrenalectomized rats supporting the role of glucocorticoids in gastroprotection. RU-38486, which occupied glucocorticoid receptors, similar to metyrapone prevented the gastroprotective effect of RIPC and, moreover, further aggravated the deleterious effect of I/R. The results of the present study demonstrate for the first time that RIPC may protect the gastric mucosa against I/R-induced injury through involvement of glucocorticoids.
Comprehensive Treatment of Trans-Arterial Chemoembolization Plus Lenvatinib Followed by Camrelizumab for Advanced Hepatocellular Carcinoma Patients
Authors: Liu Juanfang , Li Zhen , Zhang Wenguang , Lu Huibin , Sun Zhanguo , Wang Guozheng , Han Xinwei 
Published: October 2021

Aim: This study aimed to report the efficacy and safety of trans-arterial chemoembolization (TACE) plus lenvatinib and camrelizumab in patients with advanced hepatocellular carcinoma (HCC).Methods: This retrospective study enrolled 22 patients with advanced HCC from March 2018 to December 2019. All the patients received comprehensive treatment with TACE plus lenvatinib followed by camrelizumab. Overall survival (OS) and progression-free survival (PFS) were calculated and analysed using the Kaplan-Meier method and log-rank test. Treatment response and adverse events (AEs) were also evaluated.Results: The objective response rate (ORR) and disease control rate (DCR) for the whole cohort were 68.2 and 100% at the first month and 72.7 and 95.5% at the third month, respectively. The median OS was 24 months (95% CI, 20.323–27.677 months), and the median PFS was 11.4 months (95% CI, 8.846–13.954 months). The majority of treatment-related adverse reactions were mild or moderate, except for 4 that developed to grade 3–4 (3 reactions of grade 3, 1 reaction of grade 4). No deaths or other serious adverse reactions occurred.Conclusion:Trans-arterial chemoembolization plus lenvatinib and camrelizumab shows good results incontrolling tumour progression and prolonging median OS in patients with advanced HCC.
Sensor-Based Categorization of Upper Limb Performance in Daily Life of Persons With and Without Neurological Upper Limb Deficits
Authors: Barth Jessica , Lohse Keith R. , Konrad Jeffrey D. , Bland Marghuertta D. , Lang Catherine E. 
Published: October 2021

Background: The use of wearable sensor technology (e. g., accelerometers) for tracking human physical activity have allowed for measurement of actual activity performance of the upper limb (UL) in daily life. Data extracted from accelerometers can be used to quantify multiple variables measuring different aspects of UL performance in one or both limbs. A limitation is that several variables are needed to understand the complexity of UL performance in daily life.Purpose: To identify categories of UL performance in daily life in adults with and without neurological UL deficits.Methods: This study analyzed data extracted from bimanual, wrist-worn triaxial accelerometers from adults from three previous cohorts (N = 211), two samples of persons with stroke and one sample from neurologically intact adult controls. Data used in these analyses were UL performance variables calculated from accelerometer data, associated clinical measures, and participant characteristics. A total of twelve cluster solutions (3-, 4-, or 5-clusters based with 12, 9, 7, or 5 input variables) were calculated to systematically evaluate the most parsimonious solution. Quality metrics and principal component analysis of each solution were calculated to arrive at a locally-optimal solution with respect to number of input variables and number of clusters.Results: Across different numbers of input variables, two principal components consistently explained the most variance. Across the models with differing numbers of UL input performance variables, a 5-cluster solution explained the most overall total variance (79%) and had the best model-fit.Conclusion: The present study identified 5 categories of UL performance formed from 5 UL performance variables in cohorts with and without neurological UL deficits. Further validation of both the number of UL performance variables and categories will be required on a larger, more heterogeneous sample. Following validation, these categories may be used as outcomes in UL stroke research and implemented into rehabilitation clinical practice.
The Effects of Nosema apis and Nosema ceranae Infection on Survival and Phenoloxidase Gene Expression in Galleria mellonella (Lepidoptera: Galleriidae) Compared to Apis mellifera
Authors: Özgör Erkay 
Published: October 2021

The study aims to prove the possibility of colonization of N. apis and N. ceranae to the intestine of the greater wax moth, detect the differences of greater wax moth based on the presence of Nosema species and examine the effect of Nosema species on the phenoloxidase level of greater wax moth compared with honeybees. Each group was fed on the 1st day of the experiment with its appropriate diet containing 106 Nosema spores per insect. Each group was checked daily, and dead insects were counted. Furthermore, changes in the level of expression of the phenoloxidase-related gene after Nosema spp. treatment on the 6th, 9th and 12th days, which was detected by Q-PCR, and the mRNA level of phenoloxidase gene were measured in all experiment groups with the CFX Connect Real-Time PCR Detection System. This study shows that Apis mellifera L. has a 66.7% mortality rate in mixed Nosema infections, a 50% mortality rate in N. ceranae infection, a 40% mortality rate in N. apis infection, while there is no death in G. mellonella. A significant difference was found in the mixed Nosema infection group compared to the single Nosema infection groups by means of A. mellifera and G. mellonella (Duncan, p < 0.05). G. mellonella histopathology also shows that Nosema spores multiply in the epithelial cells of greater wax moth without causing any death. The increase in the mRNA level of Phenoloxidase gene in A. mellifera was detected (Kruskal–Wallis, p < 0.05), while the mRNA level of the Phenoloxidase gene did not change in G. mellonella (Kruskal–Wallis, p > 0.05). These findings prove that the Nosema species can colonize into the greater wax moth, which contributes to the dissemination of these Nosema species between beehives.
Stres Kerja terhadap Kepuasan Kerja pada Pengemudi Gojek Salatiga selama Pandemi COVID-19
Authors: Bayuaji Bagaskoro 
Published: October 2021

The purpose of this study is to examine the impact of job stress on job satisfaction among Gojek online drivers in Salatiga. The number of participants in this study was 50 that data collected by using questionnaire with Incidental Sampling technique. This study used a quantitative approach with simple linear regression data analysis. The results showed that there was a significant negative impact between job stress on job satisfaction among Gojek online drivers in Salatiga with -2,053 t-value (t-value -2,053> t-table 2,009) and 0,045 significance value (Sig.<0,05). These results indicated that the higher job stress among Gojek online drivers, the lower would be job satisfaction among them.
Keywords: job stress, job satisfaction, online drivers, pandemy, covid-19.
PENGARUH KOMPETENSI, MOTIVASI DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PDAM TIRTA RANDIK SEKAYU KABUPATEN MUSI BANYUASIN
Authors: Mindari Ellisyah 
Published: October 2021

Penelitian ini bertujuan untuk menguji pengaruh kompetensi, motivasi dan lingkungan kerja terhadap kinerja karyawan PDAM Tirta Randik Sekayu Kabupaten Musi Banyuasin. Penelitian ini menggunakan pendekatan kuantitatif. Dalam penarikan sampel yang peneliti lakukan dengan menggunakan metode slovin. Sampel dalam penelitian ini adalah karyawan PDAM Tirta Randik Sekayu dengan junlah responden sebanyak 76 karyawan. Metode analisis dengan menggunakan alat analisis dengan bantuan program SPSS Versi 17.0. Hasil penelitian ini menunjukan bahwa ada pengaruh yang positif dan signifikan kompetensi, motivasi dan lingkungan kerja secara bersama-sama terhadap kinerja karyawan dengan nilai Fhitung (45,776) Ftabel (2,732) dan nilai signifikan 0,000. Selanjutnya berdasarkan hasil uji t untuk variabel kompetensi (x1) diperoleh nilai thitung (0,734) nilai ttabel 1,993, nilai signifikan t sebesar 0,465 nilai α (0,05), sehingga dapat disimpulkan bahwa kompetensi (x1) secara parsial tidak berpengaruh secara signifikan terhadap kinerja (Y). Variabel motivasi (x2) diperoleh nilai thitung (2,743) nilai ttabel (1,993), nilai signifikan t sebesar 0,008 nilai α (0,05). Dengan hasil tersebut berarti bahwa motivasi (x2) secara parsial berpengaruh positif dan signifikan terhadap kinerja (Y). Sementara itu, hasil uji t untuk variabel lingkungan kerja (x3) dihasilkan nilai thitung (4,637) nilai ttabel (1,993), nilai signifikan t sebesar 0,000 nilai α (0,05). Dari hasil tersebut berarti bahwa lingkungan kerja (x3) secara parsial berpengaruh positif dan signifikan terhadap kinerja (Y).
DAMPAK STRUKTUR KEPEMILIKAN TERHADAP KEPUTUSAN PENDANAAN PADA PERUSAHAAN MANUFAKTUR (Suatu Penelitian Eksperimen)
Authors: Banding Mappa Panglima , Hasnawati Hasnawati 
Published: October 2021

Penelitian ini bertujuan untuk mengkaji dan memperoleh bukti empiris dari dampak struktur kepemilikan terhadap keputusan pendanaanpada perusahaan manufaktur. Jenis penelitian ini adalah eksperimen laboratorium dengan mengunakan completely randomized designs (CR- p). Dimana sampelnya adalah randomized partisipan (partisipan acak) sebanyak 20 orang berdasarkan kategori yang telah ditentukan sebelumnya dan dibagi menjadi dua kelompok yang menjadi pengambil keputusan yang propesional. Partisipan diperhadapkan dengan dua treatment manipulasi. Berdasarkan analisis data ANOVA peneliti memperoleh hasil bahwa data yang diambil adalah efektif. Dari teknik analisis data yang digunakan untuk menguji hipotesis adalah Repeated Measures t Test menggunakan sofware SPSS 23,0 dengan data berupa hasil pengisian foam simulasi pembuatan keputusan pendanaan. Dan dari hasil pengujian diperoleh bahwa kinerja keuangan berimplikasi terhadap keputusan pendanaan.
strategi pengembangan sektor industri kecil kota tarakan
Authors: Fahreza zulkarnain Muhammad Andra , Wijayanti Asih Kusuma 
Published: October 2021

Abstrak : Banyak potensi yang dapat di kembangkan di Tarakan di antaranya pada sector kelautan dan perikanan, sector pariwisata, industri dan perdagangan serta investasi di sector energi. Dengan berbagai potensi tersebut peluang pengembangan UMKM di Kota Tarakan Provinsi Kalimantan Utara menjadi strategis. Posisi Wilayah Kalimantan Utara yang berbatasan langsung dengan negara jiran Malaysia, menjadikan UMKM harus berbenah diri dalam meningkatkan daya saingnya terlebih lagi dengan pemberlakuan perdagangan bebas pada ASEAN Economic Community (AEC) sejak tahun 2015. Untuk itu strategi pengembangan usaha bagi UMKM perlu dirumuskan dan dapat menjadi rekomendasi bagi pemerintah dan stakeholder lainnya dalam membuat kebijakan pemberdayaan UMKM di Kota Tarakan. (Ariani, Utomo. 2017). Tujuan penelitian yaitu untuk mengetahui strategi pengembangan sektor industri kecil di Kota Tarakan. Objek penelitian ini adalah industry kecil di Kota Tarakan menurut jenis usaha. Perumusan strategi pengembangan industri kecil di Kota Tarakan perlu adanya identifikasi mengenai kekuatan dan kelemahan sebagai faktor internal dan faktor eksternal berupa peluang dan ancaman. Dari hasil olah data diketahui bahwa posisi kuadran industri kecil di Kota Tarakan terletak di kuadran 1 atau terletak antara peluang eksternal dan kelemahan internal. Berdasarkan posisi kuadrannya, strategi yang digunakan adalah strategi SO ( Strength - Opportunity ), yaitu strategi yang meminimalkan kelemahan dan memanfaatkan peluang. Alternatif strategi SO yang dirumuskan adalah sebagai membuat akun media sosial untuk mempermudah promosi dalam penjualan produk. Di zaman yang modern dan serba memanfaatkan kecanggihan teknologi, media sosial yang beragam saat ini dapat dijadikan sebagai alat untuk melakukan promosi. Media sosial menjadi salah satu alat promosi yang efektif karena dapat secara langsung memberikan infromasi kepada pasar penjualan hasil produksi industri kecil. Selain itu membuka cabang di luar wilayah industri. Dengan membuka cabang usaha di wilayah lain akan meningkatkan produksi dan cakupan wilayah pemasaran hasil industri kecil.
analisis strategi pengembangan ukm amplang bulan-bulan azzahra trk di kota tarakan
Authors: Rahmawati Meylin 
Published: October 2021

Abstrak : Usaha amplang ikan bulan-bulan Azzahra di Kota Tarakan merupakan salah satu usaha rumah tangga yang memproduksi amplang ikan bulan-bulan. Tujuan dari penelitian ini untuk menganalisis strategi pengembangan amplang ikan bulan-bulan Azzahra. Berdasarkan hasil pembobotan menggunakan alat analisis SWOT diperoleh skor terbobot dari faktor internal dan eksternal. Total nilai yang diperoleh dari faktor internal yaitu strength 2,23 dan weakness 1,05 dan dari faktor eksternal yaitu opportunities 1,28 dan threats 0,98. Hal tersebut menunjukkan faktor peluang yang dimiliki oleh UKM Amplang Ikan Bulan-Bulan Azzahra lebih besar dari ancaman. Dapat disimpulkan bahwa strategi pengembangan yang dapat digunakan yaitu strategi SO (Strength – Opportunities) dengan menggunakan kekuatan yang dimiliki untuk memanfaatkan peluang yang ada.
Dukungan Sosial Dalam Adaptasi Kehidupan Klien Kanker Payudara di Kabupaten Garut
Authors: Witdiawati Witdiawati , Purnama Dadang , Eriyani Theresia 
Published: October 2021

Kanker payudara merupakan kanker paling umum pada wanita di seluruh dunia, dengan hampir 1,7 juta kasus baru didiagnosis pada tahun tahun 2012. Jawa Barat merupakan salah satu provinsi sebagai penyumbang jumlah kasus kanker payudara ketiga tertinggi di Indonesia. Tujuan penelitian ini adalah mengidentifikasi makna dukungan sosial dalam adaptasi kehidupan klien kanker payudara. Rancangan penelitian dengan pendekatan kualitatif fenomenologi. Pengumpulan data dengan teknik wawancara dan observasi partisipasi dengan subyek penelitian 6 Key informan individu yang mempunyai penyakit kanker payudara. Transkripsi data di analisis menggunakan metoda analisis tematik. Hasil penelitian menunjukan 3 tema muncul sebagai pemaknaan dari dukungan sosial dalam adaftasi kehidupan klien kanker payudara yaitu dukungan sosial membantu adaptasi klien dalam menjalani kehidupan, dukungan keluarga sebagai kekuatan dan jaringan sosial sebagai akses informasi pengobatan. Perjalananan kehidupan klien kanker payudara tidak terlepas dari pengaruh dukungan sosial. Dukungan sosial sangat bermakna dan menjadi satu kekuatan dalam adaftasi kehidupan klien kanker payudara, sehingga terbentuk mekanisme koping yang adaptif dalam menghadapi kondisi penyakit nya dan aktivitas sosial sebagai wujud adaftasinya. Perlu penguatan dukungan sosial berbasis masyarakat dalam pengelolaan pelayanan kesehatan terhadap klien kanker payudara.