bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion
Authors: Villodre Emilly S. , Hu Xiaoding , Larson Richard , Finetti Pascal , Gomez Kristen , Balema Wintana , Stecklein Shane R. , Santiago-Sanchez Ginette , Krishnamurthy Savitri , Song Juhee , Su Xiaoping , Ueno Naoto T. , Tripathy Debu , Laere Steven Van , Bertucci Francois , Vivas-Mejía Pablo , Woodward Wendy A. , Debeb Bisrat G. 
Published: March 2021

AbstractInflammatory breast cancer (IBC) is an aggressive form of primary breast cancer characterized by rapid onset and high risk of metastasis and poor clinical outcomes. The biological basis for the aggressiveness of IBC is still not well understood and no IBC-specific targeted therapies exist. In this study we report that lipocalin 2 (LCN2), a small secreted glycoprotein belonging to the lipocalin superfamily, is expressed at significantly higher levels in IBC versus non-IBC tumors, independently of molecular subtype. LCN2 levels were also significantly higher in IBC cell lines and in their culture media than in non-IBC cell lines. High expression was associated with poor-prognosis features and shorter overall survival in IBC patients. Depletion of LCN2 in IBC cell lines reduced proliferation, colony formation, migration, and cancer stem cell populations in vitro, and inhibited tumor growth, skin invasion, and brain metastasis in mouse models of IBC. Analysis of our proteomics data showed reduced expression of proteins involved in cell cycle and DNA repair in LCN2-silenced IBC cells. Our findings support that LCN2 promotes IBC tumor aggressiveness and offer a new potential therapeutic target for IBC.
P2X7 receptor signaling is not required but can enhance Th17 differentiation
Authors: Yang Yin , Killeen Meaghan E. , Sumpter Tina L. , Mathers Alicia R. 
Published: March 2021

AbstractThe purinergic receptor P2X7 (P2X7R) is important in inflammasome activation and generally considered to favor proinflammatory Th17 immune responses. However, several studies utilizing P2rx7-/-mice did not observe impaired inflammation, on the contrary, these reports demonstrate that P2rx7-/-mice can have more sever inflammation compared to WT controls. To begin to clarify this discrepancy, the impact of P2X7R signaling on primary Th17 and Th1 cell responses was examined. Initially, utilizing a global knockout approach, we found that P2rx7-/-mice develop comparable Th17 and Th1 responses to those of WT mice. However, indepthin vitroandin vivoinvestigations revealed differences in the immune response outcome depending on which cell type expresses P2X7R. In this regard, DC-specific P2X7R deficient chimeras demonstrate a comparable Th17 differentiation pattern with that of WT chimeras but display a significantly enhanced Th1 response. However, P2rx7-/-T cells have a suppressed Th17 differentiation profile while developing a similarly enhanced Th1 response as observed in DC-specific P2X7R deficient chimeras. Finally, P2X7R expression induces more T cell deathin vivo, attributed to its cytotoxicity, which results in a similar total number of WT Th17 and P2rx7-/-Th17 cells and remarkably higher amounts of P2rx7-/-Th1 cells. Collectively, our findings establish that P2X7R expression on CD4+T cells is necessary for Th17 differentiation while inhibiting Th1 development.
CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM
Authors: Serra Lleti José M. , Steyer Anna M. , Schieber Nicole L. , Neumann Beate , Tischer Christian , Hilsenstein Volker , Holtstrom Mike , Unrau David , Kirmse Robert , Lucocq John M. , Pepperkok Rainer , Schwab Yannick 
Published: March 2021

AbstractCorrelative light and electron microscopy (CLEM) combines two imaging modalities, balancing out the limits of one technique with the other. In recent years, Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) has emerged as a flexible method that enables semi-automated volume acquisition at the ultrastructural level. We present a toolset for adherent cultured cells that enables tracking and finding cell regions previously identified in light microscopy, in the FIB-SEM along with automatic acquisition of high-resolution volume datasets. We detect a grid pattern in both modalities (LM and EM), which identifies common reference points. The novel combination of these techniques enables complete automation of the workflow. This includes setting the coincidence point of both ion and electron beams, automated evaluation of the image quality and constantly tracking the sample position with the microscope’s field of view reducing or even eliminating operator supervision. We show the ability to target the regions of interest in EM within 5µm accuracy, while iterating between different targets and implementing unattended data acquisition. Our results demonstrate that executing high throughput volume acquisition in electron microscopy is possible.
The time-resolved hard X-ray diffraction endstation KMC-3 XPP at BESSY II
Authors: Rössle Matthias , Leitenberger Wolfram , Reinhardt Matthias , Koç Azize , Pudell Jan , Kwamen Christelle , Bargheer Matias 
Published: March 2021

The time-resolved hard X-ray diffraction endstation KMC-3 XPP for optical pump/X-ray probe experiments at the electron storage ring BESSY II is dedicated to investigating the structural response of thin film samples and heterostructures after their excitation with ultrashort laser pulses and/or electric field pulses. It enables experiments with access to symmetric and asymmetric Bragg reflections via a four-circle diffractometer and it is possible to keep the sample in high vacuum and vary the sample temperature between ∼15 K and 350 K. The femtosecond laser system permanently installed at the beamline allows for optical excitation of the sample at 1028 nm. A non-linear optical setup enables the sample excitation also at 514 nm and 343 nm. A time-resolution of 17 ps is achieved with the `low-α' operation mode of the storage ring and an electronic variation of the delay between optical pump and hard X-ray probe pulse conveniently accesses picosecond to microsecond timescales. Direct time-resolved detection of the diffracted hard X-ray synchrotron pulses use a gated area pixel detector or a fast point detector in single photon counting mode. The range of experiments that are reliably conducted at the endstation and that detect structural dynamics of samples excited by laser pulses or electric fields are presented.
Constructive schemes to spacecraft attitude control with low communication frequency using sampled-data and encryption approaches
Authors: Zhang Chengxi , Wu Jin , Huang Yulong , Jiang Yu , Dai Ming-zhe , Wang Mingjiang 
Published: March 2021

Purpose
Recent spacecraft attitude control systems tend to use wireless communication for cost-saving and distributed mission purposes while encountering limited communication resources and data exposure issues. This paper aims to study the attitude control problem with low communication frequency under the sampled-data.

Design/methodology/approach
The authors propose constructive control system structures based on quantization and event-triggered methods for intra-spacecraft and multi-spacecraft systems, and they also provide potential solutions to shield the control system's data security. The proposed control architectures can effectively save communication resources for both intra-spacecraft and multi-spacecraft systems.

Findings
The proposed control architectures no longer require sensors with trigger-ing mechanism and can achieve distributed control schemes. This paper also provides proposals of employing the public key encryption to secure the data in control-loop, which is transmitted by the event-triggered control mechanism.

Practical implications
Spacecraft attempts to use wireless communication, yet the attitude control system does not follow up promptly to accommodate these variations. Compared with existing approaches, the proposed control structures can save communication resources of control-loop in multi-sections effectively, and systematically, by rationally configuring the location of quantization and event-triggered mechanisms.

Originality/value
This paper presents several new control schemes and a necessary condition for the employment of encryption algorithms for control systems based on event-based communication.
AMO perspectives on the well-being of neurodivergent human capital
Authors: Szulc Joanna Maria , Davies Julie , Tomczak Michał T. , McGregor Frances-Louise 
Published: March 2021

PurposeExisting management research and management practices frequently overlook the relationship between the above-average human capital of highly functioning neurodivergent employees, their subjective well-being in the workplace and performance outcomes. This paper calls for greater attention to the hidden human capital associated with neurodiversity by mainstreaming implementation of neurodiversity-friendly policies and practices.Design/methodology/approachDrawing on the ability, motivation and opportunity (AMO) framework, this conceptual paper integrates research on employee neurodiversity and well-being to provide a model of HR-systems level and human capital development policies, systems and practices for neurodivergent minorities in the workplace.FindingsThis paper illustrates that workplace neurodiversity, like biodiversity, is a natural phenomenon. For subjective individual psychological and organisational well-being, neurodivergent employees require an empathetic culture and innovative talent management approaches that respect cognitive differences.Practical implicationsThe case is made for neurodivergent human capital development and policy-makers to promote inclusive employment and decent work in a context of relatively high unemployment for neurodivergent individuals.Originality/valueThis paper extends current debates on organisational equality, diversity and inclusion to a consideration of workplace well-being for highly functioning neurodivergent workers. It calls for more equitable and empathetic approaches to investing in employees with neurodevelopmental and cognitive disabilities.
Developing entrepreneurial competencies in higher education: a structural model approach
Authors: Ferreras-Garcia Raquel , Sales-Zaguirre Jordi , Serradell-López Enric 
Published: March 2021

PurposeThe aim of this article is to propose and test a structural model of relationships between generic and specific competencies and entrepreneurial competencies in order to assess students' learning.Design/methodology/approachThe study was carried out on a sample of 337 students enrolled on the entrepreneurship specialisation of the final bachelor's degree project course on the Bachelor's Degree in Business Administration and Management at the Universitat Oberta de Catalunya. A questionnaire was designed to gather information on students' perception of their level of acquisition of the different groups of competencies. The partial least squares (PLS) multivariate technique was used to analyse the model.FindingsThe results confirm that there are significant relationships between the different groups of competencies. Specifically, it shows that generic competencies influence specific competencies and that there is a strong relationship between systemic and professional competencies and entrepreneurial competencies. It also shows that the experience variable contributes positively to different competency groups, while the gender and age variables have no effect on the development of entrepreneurial competencies.Practical implicationsThe study provides relevant information to the academic world on different factors that affect competency development.Originality/valueThe analysis provides an innovative research and contributes knowledge on entrepreneurial competency acquisition, providing an answer to whether generic and specific competencies influence entrepreneurial competencies.
Research on the influence of college students’ crowd decision-making on improving the content of public account tweets
Authors: Yang Xiangpeng , He Yi 
Published: March 2021

Purpose
As human beings step into the age of information network, big data technology is constantly improving the intelligence level of various agents such as individuals and enterprises. The crowd decision-making of the intellectual community plays an important role in the active participation of many individuals and schools in giving their wisdom, effectively solve the problems of negative internet communication, single publicity media and unprofessional promotion team in WeChat public account.

Design/methodology/approach
This paper aims to optimize the content and improve the effectiveness of network ideological and political education in universities. This study analyzes five highly popular WeChat public accounts at the Central University of Finance and Economics in 2019. It obtains the popularity index of tweets using the WeChat communication index algorithm and finds that the important factors that influence tweet popularity are release time and content value.

Findings
To improve the public account tweets, this study highlights the connection between the tweets’ value and students’ emotional needs, which enhances the value of tweet content in students’ life and provides more original and distinctive content.

Originality/value
This study found that the content and interest of college students are tweet time, tweet value and tweet content. Therefore, the public account of college ideological and political education should be improved from the following three aspects: realizing the connection between the value of tweet content and students’ emotional needs; enhancing the value of tweet content in students’ life and learning; and insisting on the original and distinctive original intention of tweet content.
The influence of technological interactivity and media sociability on sport consumer value co-creation behaviors via collective efficacy and collective intelligence
Authors: Lee Younghan , Kim Dae-eun 
Published: March 2021

PurposeThe current study aims to explain the influence of technological interactivity and media sociability on sport consumer value co-creation behavior via collective efficacy and collective intelligence.Design/methodology/approachSubjects were individuals who have a mobile smart device and experience of accessing sport-related community websites (n = 513). A face-to-face self-administered survey was employed based on the convenience sampling method. A structural equation modeling test was conducted to examine the relationships between the variables.FindingsTechnological interactivity and media sociability based on mobile smart devices improve sport consumers' collective efficacy, and media sociability positively affects collective intelligence. Also, perceived collective efficacy and collective intelligence in virtual communities induce consumers to engage in the value co-creation process more actively (i.e. consumer participation behavior and citizenship behavior). One of the key findings includes the significant role of media sociability in the process of value co-creation between consumers and sport organizations. Media sociability is more likely to contribute to improving sport consumers' collective efficacy and the development of intelligence than the properties of technological interactivity.Originality/valueResearch findings contribute to extending the body of knowledge in interactivity studies related to sport consumers' value co-creation behaviors in the virtual environment context.
Blockchain performance in supply chain management: application in blockchain integration companies
Authors: Hong Leo , Hales Douglas N. 
Published: March 2021

PurposePerformance assessment of blockchain in the supply chain requires a systematic approach because of its interdisciplinary and multiobjective nature. Hence, four types of performance domains are identified, namely, environmental, economic, customer and information.Design/methodology/approachThe following methodologies have been utilized: (1) literature review to find relevant factors, (2) factor analysis to validate factors and (3) DEMATEL theory to find the cause and effect relationships amongst performance measures.FindingsAn integrated holistic performance assessment model incorporating the 4 criteria and 25 subcriteria is applied.Originality/valueThis is the first paper to analyze blockchain performance in an industry setting.
Importing a management accounting concept into the Russian language: a case of resistance from Russian academics
Authors: Golyagina Alena 
Published: March 2021

PurposeDrawing on the semantic field theory, the paper aims to uncover the challenges of importing and translating a management accounting concept into the Russian language and the semantic nature of resistance towards the imported management accounting concept.Design/methodology/approachThe paper draws on the extensive literature review of the histories of accounting in the Soviet Union and the United States in the first part of the twentieth century and 17 interviews conducted with the Russian accounting academics.FindingsWe demonstrate the case of resistance in adopting the imported Anglo-Saxon management accounting concept. We also discuss historical underpinning and origins of this resistance in light of semantic field theory.Research limitations/implicationsThe paper calls for more research in the non-Anglo-Saxon contexts problematizing conventional assumptions and beliefs about objectivity and universality of accounting language.Practical implicationsThe study demonstrates the importance of understanding historical and cross-cultural developments of accounting language for accounting educators and practitioners. Critical awareness of the differences in semantic fields of accounting can help accounting researchers and educators to develop contextualized research projects and context-relevant teaching practices.Originality/valueThe study contributes to the literature on translations of accounting concepts by demonstrating that accounting concepts are not understood in isolation, instead, they are interpreted in relation to each other. The present study demonstrates that the relationship between the management accounting concept (the signifier) and its meanings (signifieds) is fluid, culturally and historically contingent. To understand this relationship, we should attend to the historical development of semantic fields and associative relations between concepts.
Optimising building performance through integrating risk management and building information modelling during the design process
Authors: Othman Ayman Ahmed Ezzat , Alamoudy Fatma Othman 
Published: March 2021

Purpose
This paper aims to develop a framework for optimising building performance through the integration between risk management (RM) and building information modelling (BIM) during the design process.

Design/methodology/approach
To achieve this aim, a research strategy consisting of literature review, case studies and survey questionnaire is designed to accomplish four objectives. First, to examine the concepts of design process, building performance, RM and BIM; second, to present three case studies to explain the role of using RM and BIM capabilities towards optimising building performance; third, to investigate the perception and application of architectural design firms in Egypt towards the role of RM and BIM for enhancing building performance during the design process; and finally, to develop a framework integrating RM and BIM during the design process as an approach for optimising building performance.

Findings
Through literature review, the research identified 18 risks that hamper optimising building performance during the design process. In addition, 11 building performance values and 20 BIM technologies were defined. Results of data analysis showed that “Design budget overrun”, “Lack of considering life cycle cost” and “Inefficient use of the design time” were ranked the highest risks that affect the optimisation of building performance. Respondents ranked “Risk avoid” or “Risk transfer” as the most risk responses adopted in the Egyptian context. In addition, “BIM As Built” was ranked the highest BIM technology used for overcoming risks during the design process. These findings necessitated taking action towards developing a framework to optimising building performance.

Originality/value
The research identified the risks that affect optimising building performance during the design process. It focuses on improving the design process through using the capabilities of BIM technologies towards overcoming these risks during the design process. The proposed framework which integrates RM and BIM represents a synthesis that is novel and creative in thought and adds value to the knowledge in a manner that has not previously occurred.
Improved black widow-bear smell search algorithm (IBWBSA) for optimal planning and operation of distributed generators in distribution system
Authors: K. R. Sathish , Ananthapadmanabha T. 
Published: March 2021

Purpose
This paper aims to propose, the multi-objective method for optimal planning and operation of distributed generators (DGs) on distribution system (DS) using hybrid technique is proposed.

Design/methodology/approach
The proposed hybrid technique denotes hybrid wrapper of black widow optimization algorithm (BWOA) and bear smell search algorithm (BSSA). BWOA accelerates the convergence speed with combination of the search strategy of BSSA; hence, it is named as improved black widow-bear smell search algorithm (IBWBSA) technique.

Findings
The multiple-objective operation denotes reducing generation cost, power loss, voltage deviation with optimally planning and operating the DS. For setting up the DG units on DS, IBWBSA technique is equipped to simultaneously reconfigure and find the optimal areas.

Originality/value
In this planning model, the constraints are power balance, obvious power flow limit, bus voltage, distribution substation’s capacity and cost. Then, proposed multiple-objective hybrid method to plan electrical distribution scheme is executed in the MATLAB/Simulink work site.
The effect of brand personality congruence, brand attachment and brand love on loyalty among HENRY's in the luxury branding sector
Authors: Shetty Khyati , Fitzsimmons Jason R. 
Published: March 2021

PurposeThe purpose of this research study is to empirically investigate a hypothesized theoretical framework that captures the impact of brand personality congruence, brand love and brand attachment on brand loyalty in the luxury branding sector.Design/methodology/approachEmpirical data were gathered from 416 millennial shoppers with incomes from US$100,000 and above (High-Earners-Not–Rich-Yet). Structural equation modeling was used to test the hypotheses of the framework developed for the study. Dubai is chosen as the context of the study based on the fact that the luxury brands sector is one of the leading industries in the country, and has a sizeable population of HENRY's.FindingsThe findings of this study revealed that brand personality congruence is a critical determinant of brand love and brand loyalty, suggesting congruence between the consumer's personality and the brand is essential to the luxury branding sector. The study also establishes a relationship between brand attachment and brand loyalty.Research limitations/implicationsThis study offers new empirical support for the proposition that consumers' emotional aspects like brand personality congruence and brand love are critical for enhancing brand loyalty toward luxury. The findings from this study can provide brand managers with a guide to managing their branding strategies and understand the strategic role of these variables on communication strategies for a new emerging segment of the HENRY's customer segment.Originality/valueThis study contributes to luxury branding and a new segment of millennials by examining the relationship between brand personality congruence, brand love, brand attachment and its effect on brand loyalty in the luxury branding context.