bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-Load Blood Flow Restriction and High-Load Resistance Training Induce Comparable Changes in Patellar Tendon Properties
Authors: Centner Christoph , Jerger Simon , Lauber Benedikt , Seynnes Olivier , Friedrich Till , Lolli David , Gollhofer Albert , König Daniel 
Published: November 2021

ABSTRACT

Introduction
Low-load resistance training with blood flow restriction (LL-BFR) has emerged as a viable alternative to conventional high-load (HL) resistance training regimens. Despite increasing evidence confirming comparable muscle adaptations between LL-BFR and HL resistance exercise, only very little is known about tendinous mechanical and morphological adaptations after LL-BFR. Therefore, the aim of the present study was to examine the effects of 14 wk of LL-BFR and HL training on patellar tendon adaptations.

Methods
Twenty-nine recreationally active male participants were randomly allocated into the following two groups: LL-BFR resistance training (20%–35% one-repetition maximum (1RM)) or HL resistance training (70%–85% 1RM). Both groups trained three times per week for 14 wk. One week before and after the intervention, patellar tendon mechanical and morphological properties were assessed via ultrasound and magnetic resonance imaging. In addition, changes in muscle cross-sectional area were quantified by magnetic resonance imaging and muscle strength via dynamic 1RM measurements.

Results
The findings demonstrated that both LL-BFR and HL training resulted in comparable changes in patellar tendon stiffness (LL-BFR: +25.2%, P = 0.003; HL: +22.5%, P = 0.024) without significant differences between groups. Similar increases in tendon cross-sectional area were observed in HL and LL-BFR. Muscle mass and strength also significantly increased in both groups but were not statistically different between HL (+38%) and LL-BFR (+34%), except for knee extension 1RM where higher changes were seen in LL-BFR.

Conclusions
The present results support the notion that both HL and LL-BFR cause substantial changes in patellar tendon properties, and the magnitude of changes is not significantly different between conditions. Further studies that examine the physiological mechanisms underlying the altered tendon properties after LL-BFR training are needed.
Classification of Runners with High versus Low Hip Adduction Based on Measures of Pelvis and Femur Morphology
Authors: Liu Jia , Powers Christopher M. 
Published: November 2021

ABSTRACT

Purpose
To determine the most relevant pelvis and femur morphological characteristics for differentiating runners with high versus low hip adduction during running.

Methods
Fifteen female and 14 male runners underwent instrumented kinematics analysis of overground running and computed tomography scanning of pelvis and femur. The peak hip adduction angle during the stance phase of running was identified for each participant. Using the cohort average of the peak hip adduction angle as the classifying threshold, participants were categorized into high or low hip adduction groups. To determine the most relevant morphologic features for discriminating high and low hip adduction runners, a feature selection-based support vector machine classification analysis was performed.

Results
Of the 15 morphology variables examined, femoral head anteversion and femur length were shown to be the best discriminant variables for group classification. Together, these variables achieved a prediction accuracy of 0.93, sensitivity of 1.0, and specificity of 0.88.

Conclusions
Our results highlight the importance of femur morphology in contributing to increased hip adduction during running.
Tart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage
Authors: Wangdi Jimmy T. , O’Leary Mary F. , Kelly Vincent G. , Jackman Sarah R. , Tang Jonathan C. Y. , Dutton John , Bowtell Joanna L. 
Published: November 2021

ABSTRACT

Introduction
Montmorency cherry concentrate (MCC) supplementation enhances functional recovery from exercise, potentially due to antioxidant and anti-inflammatory effects. However, to date, supporting empirical evidence for these mechanistic hypotheses is reliant on indirect blood biomarkers. This study is the first to investigate functional recovery from exercise alongside molecular changes within the exercised muscle after MCC supplementation.

Methods
Ten participants completed two maximal unilateral eccentric knee extension trials after MCC or placebo (PLA) supplementation for 7 d before and 48 h after exercise. Knee extension maximum voluntary contractions, maximal isokinetic contractions, single leg jumps, and soreness measures were assessed before, immediately, 24 h, and 48 h after exercise. Venous blood and vastus lateralis muscle samples were collected at each time point. Plasma concentrations of interleukin-6, tumor necrosis factor alpha, C-reactive protein, creatine kinase, and phenolic acids were quantified. Intramuscular mRNA expressions of superoxide dismutase 1 (SOD1), SOD3, glutathione peroxidase 1 (GPX1), GPX3, GPX4, GPX7, catalase, and nuclear factor erythroid 2–related factor 2 and relative intramuscular protein expressions of SOD1, catalase, and GPX3 were quantified.

Results
MCC supplementation enhanced the recovery of normalized maximum voluntary contraction 1-s average compared with PLA (postexercise PLA, 59.5% ± 18.0%, vs MCC, 76.5% ± 13.9%; 24 h PLA, 69.8% ± 15.9%, vs MCC, 80.5% ± 15.3%; supplementation effect P = 0.024). MCC supplementation increased plasma hydroxybenzoic, hippuric, and vanillic acid concentrations (supplementation effect P = 0.028, P = 0.002, P = 0.003); SOD3, GPX3, GPX4, GPX7 (supplement effect P < 0.05), and GPX1 (interaction effect P = 0.017) gene expression; and GPX3 protein expression (supplementation effect P = 0.004) versus PLA. There were no significant differences between conditions for other outcome measures.

Conclusions
MCC supplementation conserved isometric muscle strength and upregulated antioxidant gene and protein expression in parallel with increased phenolic acid concentrations.
Retrospective trial of long acting analogues detemir and degludec usage in children and adolescents to overcome glucose variability caused by dawn phenomenon and reverse dawn phenomenon
Authors: Vitebskaya A. V. , Shreder E. V. , Popovich A. V. , Pisareva E. A. 
Published: November 2021

Backgraund: Children with type 1 diabetes mellitus (T1DM) need more insulin late in the evening (reverse dawn phenomenon (RDP)), and adolescents need more insulin yearly in the morning (dawn phenomenon (DP)); these cause blood glucose variability. Modern long acting insulin analogues allow to achieve satisfactory glycemic control.Aims: To study the characteristics of insulin therapy in children and adolescents with T1DM using insulin analogues detemir and degludec to overcome blood glucose variability caused by DP and RDP in different age periods.Materials and methods: We analyzed medical documents of 200 patients using detemir, admitted to pediatric endocrinology department in 2013–2019, at mean age 9.0 years (5.4; 13.0), with T1DM for 1.3 years (0.5; 3.0); and medical documents of 50 patients switched to degludec in 2018–2019 at mean age 12.0 years (10.5; 14.5) with T1DM for 3.0 years (1.5; 6.0). Before degludec they were on intensive insulin therapy with glargine (22), detemir (26), or insulin pump (2); 16 patients (32%) presented with clinical characteristics of DP, and 5 (10%) — RDP.Results: 67 children of 108 (62%) aged 1–9 years had redistribution of detemir doses to daytime; 58 adolescents of 92 (63%) aged 10–17 лет — to nighttime. Patients switched to degludec demonstrated decrease in HbA1с from 8.7% (7.8; 9.9) to 8.0% (7.4; 9.0) (р<0.001); fasting blood glucose from 9.8 mmol/l (7.4; 11.7) to 7.7 mmol/l (6.4; 8.6) (р<0.001); within-day variability from 35.2% (31.6; 40.9) to 23.5% (19.7; 28.6) (р<0.001); daily insulin dose from 0.98 U/kg/day (0.82; 1.14) to 0.87 U/kg/day (0.75; 1.07) (р=0.002). Sub-groups of patients with DP and RDP demonstrated decrease in fasting blood glucose (from 11.5 mmol/l (9.8; 13.8) to 7.5 mmol/l (6.6; 9.1) (р<0.001)), and late evening blood glucose (from 11.0 mmol/l (10.2; 11.2) to 8.0 mmol/l (6.7; 9.5) (р= 0.03)) correspondently. Achieved levels of glycemic control did not differ between sub-groups of patients initially using glargine or detemir.Conclusions: Compensation of T1DM may be complicated due to DP and RDP. Switching to degludec allowed to achieve better glycemic control and lowering of blood glucose variability caused by DP and DRP.
Neovascular glaucoma in patients with diabetes mellitus — the current state of the problem
Authors: Biletskaya V. A. , Lipatov D. V. , Frolov M. A. , Kazakova K. A. 
Published: November 2021

Today, diabetes is one of the leading medical and social problems. This is due to a pandemic increase in the development of the disease. Eye complications that occur against the background of diabetes are complex. Diabetic damage to the visual organ is the main cause of visual acuity in these patients. One of the serious complications of proliferative diabetic retinopathy is secondary neovascular glaucoma, which is often refractory to treatment and eventually leads to irreversible blindness. Currently, neovascular glaucoma is an important and urgent problem in modern society, as it leads a large number of patients to disability and impaired social adaptation. The paper presents a review of the literature on the current state of the problem of neovascular glaucoma and presents the results of major international studies.Based on the data of domestic and foreign literature, the authors provide up-to-date information on the incidence, evaluate the clinical manifestations of the disease, paying attention to new methods of diagnosis and treatment. These data allow us to evaluate the effectiveness of modern therapeutic and surgical approaches in the treatment of neovascular glaucoma, as well as its various complications and measures for their prevention.
Low risk of hypoglycemia and high efficacy of gliclazide MB: results of recent studies
Authors: Kononenko I. V. , Smirnova O. M. 
Published: November 2021

Sulfonylureas are widely prescribed all over the world, mainly because of their high effectiveness. At the same time, the heterogeneity of the group is obvious, primarily in relation to the effect of drugs on the risk of developing hypoglycemic events. The review presents the results of new studies, including «Comparative effectiveness of gliclazide modified release versus sitagliptin as second-line treatment after metformin monotherapy in patients with uncontrolled type 2 diabetes» and results of a model-based meta-analysis of 24 antihyperglycemic drugs for type 2 diabetes, confirming the higher efficacy of modified release gliclazide (gliclazide MB) compared to DPP-4, as well as a low risk of hypoglycemic conditions. The results of recent studies, as well as the results of the ADVANCE and ADVANCE-ON studies, suggest that gliclazide MB is safe to use as a second-line drug, especially in patients with chronic kidney disease.
Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid
Authors: Gobom Johan , Parnetti Lucilla , Rosa-Neto Pedro , Vyhnalek Martin , Gauthier Serge , Cataldi Samuela , Lerch Ondrej , Laczo Jan , Cechova Katerina , Clarin Marcus , Benet Andrea L. , Pascoal Tharick A. , Rahmouni Neserine , Vandijck Manu , Huyck Else , Le Bastard Nathalie , Stevenson Jenna , Chamoun Mira , Alcolea Daniel , Lleó Alberto , Andreasson Ulf , Verbeek Marcel M. , Bellomo Giovanni , Rinaldi Roberta , Ashton Nicholas J. , Zetterberg Henrik , Sheardova Katerina , Hort Jakub , Blennow Kaj 
Published: November 2021

Abstract

Objectives
The core cerebrospinal fluid (CSF) biomarkers; total tau (tTau), phospho-tau (pTau), amyloid β 1-42 (Aβ 1-42), and the Aβ 1-42/Aβ 1-40 ratio have transformed Alzheimer’s disease (AD) research and are today increasingly used in clinical routine laboratories as diagnostic tools. Fully automated immunoassay instruments with ready-to-use assay kits and calibrators has simplified their analysis and improved reproducibility of measurements. We evaluated the analytical performance of the fully automated immunoassay instrument LUMIPULSE G (Fujirebio) for measurement of the four core AD CSF biomarkers and determined cutpoints for AD diagnosis.

Methods
Comparison of the LUMIPULSE G assays was performed with the established INNOTEST ELISAs (Fujirebio) for hTau Ag, pTau 181, β-amyloid 1-42, and with V-PLEX Plus Aβ Peptide Panel 1 (6E10) (Meso Scale Discovery) for Aβ 1-42/Aβ 1-40, as well as with a LC-MS reference method for Aβ 1-42. Intra- and inter-laboratory reproducibility was evaluated for all assays. Clinical cutpoints for Aβ 1-42, tTau, and pTau was determined by analysis of three cohorts of clinically diagnosed patients, comprising 651 CSF samples. For the Aβ 1-42/Aβ 1-40 ratio, the cutpoint was determined by mixture model analysis of 2,782 CSF samples.

Results
The LUMIPULSE G assays showed strong correlation to all other immunoassays (r>0.93 for all assays). The repeatability (intra-laboratory) CVs ranged between 2.0 and 5.6%, with the highest variation observed for β-amyloid 1-40. The reproducibility (inter-laboratory) CVs ranged between 2.1 and 6.5%, with the highest variation observed for β-amyloid 1-42. The clinical cutpoints for AD were determined to be 409 ng/L for total tau, 50.2 ng/L for pTau 181, 526 ng/L for β-amyloid 1-42, and 0.072 for the Aβ 1-42/Aβ 1-40 ratio.

Conclusions
Our results suggest that the LUMIPULSE G assays for the CSF AD biomarkers are fit for purpose in clinical laboratory practice. Further, they corroborate earlier presented reference limits for the biomarkers.
Methods to reduce lipemic interference in clinical chemistry tests: a systematic review and recommendations
Authors: Soh Sheila X. , Loh Tze Ping , Sethi Sunil K. , Ong Lizhen 
Published: November 2021

Abstract

Objectives
Lipemia is the presence of abnormally high lipoprotein concentrations in serum or plasma samples that can interfere with laboratory testing. There is little guidance available from manufacturers or professional bodies on processing lipemic samples to produce clinically acceptable results. This systematic review summarizes existing literature on the effectiveness of lipid removal techniques in reducing interference in clinical chemistry tests.

Methods
A PubMed search using terms relating to lipid removal from human samples for clinical chemistry tests produced 1,558 studies published between January 2010 and July 2021. 15 articles met the criteria for further analyses.

Results
A total of 66 analytes were investigated amongst the 15 studies, which showed highly heterogenous study designs. High-speed centrifugation was consistently effective for 13 analytes: albumin, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, creatine kinase (CK), creatinine (Jaffe method), gamma-glutamyl transferase (GGT), glucose (hexokinase-based method), lactate dehydrogenase (LDH), phosphate, potassium, and urea. Lipid-clearing agents were uniformly effective for seven analytes: ALT, AST, total bilirubin, CK, creatinine (Jaffe method), lipase, and urea. Mixed results were reported for the remaining analytes.

Conclusions
For some analytes, high-speed centrifugation and/or lipid-clearing agents can be used in place of ultracentrifugation. Harmonized protocols and acceptability criteria are required to allow pooled data analysis and interpretation of different lipemic interference studies.
Simple modifications of nicotinic, isonicotinic, and 2,6-dichloroisonicotinic acids toward new weapons against plant diseases
Authors: Czerwoniec Patrycja , Szymkowiak Joanna , Smiglak Marcin 
Published: November 2021

Abstract
Recently, the biggest challenge in agriculture is the search for new, effective, and ecological methods of protecting plants against diseases. One of the fastest-growing and prospective strategies is a method based on activating the plant’s natural defenses. The use of suitable substances (elicitors) stimulates the immune system of plants, which makes them resistant to infections even before the first symptoms appear. This article presents preparation, characterization, phytotoxicity, and plant resistance induction efficacy of 28 ester derivatives of nicotinic, isonicotinic, and 2,6-dichloroisonicotinic acids as potential inducers of plants’ natural immune system. Plant resistance induction efficacy tests were performed on tobacco Nicotiana tabacum var. Xanthi infected by the tobacco mosaic virus (TMV).
Towards the use of acrylic acid graft-copolymerized plant biofiber in sustainable fortified composites: Manufacturing and characterization
Authors: Rana Ashvinder K. , Thakur Vijay Kumar , Singha Amar S. 
Published: November 2021

Abstract
In this study, the impact of particle form of the Cannabis indica plant biofibers and the fiber’s surface tailoring on the physical, thermal, dielectric, and mechanical properties of unsaturated polyester composite specimens manufactured utilizing nonconventional materials were investigated. The mechanical properties such as compressive, flexural, and tensile strengths of the composite specimens were noticed to increase after functionalization of biofiber with acrylic acid and maximum enhancement was found at 20% of biofiber sacking. The physical characterization was concentrated on the assurance of the dielectric constant, dielectric strength, dielectric loss, moisture absorption, chemical resistance, percentage of swelling, limiting oxygen index, and biodegradation of polymer composites under red soil. An increase in dielectric strength from 28 to 29 kV, limiting oxygen index values from 19% to 23%, and moisture/water absorption behavior was noted for resulted bio-composites after surface tailoring of biofiber. To assess the deterioration of the polymeric materials with the temperature, differential scanning calorimetric and the thermogravimetric tests were carried out and enhancement in thermal stability was noted after fortification of polyester composites with functionalized biofiber.
Towards understanding kraft lignin depolymerisation under hydrothermal conditions
Authors: Ahlbom Anders , Maschietti Marco , Nielsen Rudi , Hasani Merima , Theliander Hans 
Published: November 2021

Abstract
Kraft lignin depolymerisation using hydrothermal liquefaction suffers from the formation of char, resulting in a decreased product yield as well as causing operational problems. While this may be mitigated by the addition of capping agents such as phenol and isopropanol, other reaction parameters, for example reaction time and temperature, are also important for the product yields. In this work, the effect of short reaction times on the hydrothermal liquefaction of kraft lignin in an alkaline water and isopropanol mixture was investigated at 1–12 min and 290 °C. The results show that there were swift initial reactions: the major ether bonds in the lignin were broken within the first minute of reaction, and the molecular weight of all product fractions was halved at the very least. Longer reaction times, however, do not cause as pronounced structural changes as the initial reaction, indicating that a recalcitrant carbon-carbon skeleton remained in the products. Nevertheless, the yields of both char and monomers increased slowly with increasing reaction time. The swift initial depolymerising reactions were therefore followed by slower repolymerisation as well as a slow formation of monomers and dimers, which calls for careful tuning of the reaction time.
Study on crystallization kinetics of dry fractionation products of beef tallow
Authors: Liu Shoushan , Li Dong , He Xinyi , Li Hang , Li Xiaoyan , Liao Zhenyu , Wang Zhanzhong 
Published: November 2021

Abstract
The dry fractionation beef tallow and their products were analyzed in the dynamic thermodynamic analysis, isothermal analysis and crystallization kinetics analysis in this experiment. Through the dynamic thermodynamic analysis by DSC, the possibility of fine fractionation of beef tallow at 25 °C and 42.9 °C crystallization temperature was obtained. The dynamic thermodynamic analysis of dry fractionation products was carried out, and the linear functions of peak temperature and melting/crystallization rate of beef tallow and its stearic acid mixture were constructed. The crystallization temperature and melting point were obtained by linear function. The isothermal crystallization kinetic model was used to calculate and fit the experimental data by the Avrami model. Beef tallow and its stearic mixture were fitted with the Avrami equation to obtain R
2 ≥ 0.98. This analysis provides an innovative idea and method for thermodynamics and crystallization kinetics of beef tallow.
(Meta-)communicative work in a counselling centre for refugees: reiteration, erasure and agency
Authors: Hassemer Jonas 
Published: November 2021

Abstract

We have no apartments is a phrase repeated over and over again at the counselling centre for refugees on housing matters based in Vienna, Austria, where I conducted ethnographic fieldwork. Based on an analysis of processes of entextualisation, de- and recontextualisation in the reiterative, discursive chain, this paper traces the emergence of an institutional regime of communication and the ways institutional actors – counsellors and volunteers – produce, navigate and reproduce this regime by engaging in (meta-)communicative work. The analysis shows how individual agency is both contingent and co-productive of institutional order and social order more generally. With this contribution, I propose Judith Butler’s concept of the postsovereign subject as a way to understand the relations between “local” practices and wider processes of trans-situational meaning-making.
The dialectics of indexical semiosis: scaling up and out from the “actual” to the “virtual”
Authors: Silverstein Michael 
Published: November 2021

Abstract
Conventional indexicality is semiotically effective when regimented by its meta-indexical (or “metapragmatic”) interpretant, a conceptual scheme presumed upon by participants in communication that determines the categories of possibility for a relevant “here-and-now” of indexically signaled co-presence, just as, conversely, such an interpretant is an emergent consequence of the sign’s pointing to its object. In the more general case of non-denotational indexicality – forms indicating everything from perduring demographic characteristics of participants in interaction to their role incumbencies, voicings of identity, and momentary relational attitudes and affects (loosely termed “stances”) – the culture – and thus group-specific metapragmatics (or “ethno-metapragmatics”) is central to how indexicals entail the mutual (il)legibility of interlocutors and the (in)coherence of interactional projects in which they are engaged, the “interactional text” of what is happening. This inherent metapragmatic functionality of models of indexical signs and their contexts is, in general, itself influenced by genres of metapragmatic discourse about social life that “circulate” among networks of people who participate in certain sites of sociality. Such “circulation” is a virtual reality that comes into being via chains of interdiscursivity, allowing us to imagine an “ideological” plane with its own order of virtual semiotic dialectic that, notwithstanding, we experience in actual interactional context by its effects on the ever-changing what and how of indexicality.