bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Resolution Imaging of Complex Shallow Fault Zones Along the July 2019 Ridgecrest Ruptures
Authors: Zhou Zheng , Bianco Michael , Gerstoft Peter , Olsen Kim 
Published: December 2021

AbstractWe perform ambient noise tomography using data recorded on 342 seismographs within a 50 × 50 km area inside which the July 2019 M7.1 and M6.4 Ridgecrest earthquakes occurred. We used the locally sparse tomography (LST) method, an unsupervised machine learning approach that learns to represent small‐scale geophysical structures using only data from the immediate study. The Rayleigh group speed obtained from LST better predicts travel times than conventional regularized least squares inversion. The 3D shear velocity model of the area obtained from the surface wave dispersion maps reveals a highly heterogeneous low‐velocity zone (with the primary velocity reduction in the upper 2–3 km) around the causative faults for the M7.1 and M6.4 events, with a 40% reduction of the shear wave velocity. Further, correlation of other imaged LVZs in the model area with parts of the Little Lake Fault System without recent activity may indicate long‐lasting damage zones.
Simulations of Energetic Neutral Atom Sputtering From Ganymede in Preparation for the JUICE Mission
Authors: Pontoni A. , Shimoyama M. , Futaana Y. , Fatemi S. , Poppe A. R. , Wieser M. , Barabash S. 
Published: December 2021

AbstractJovian magnetospheric plasma irradiates the surface of Ganymede and is postulated to be the primary agent that changes the surface brightness of Ganymede, leading to asymmetries between polar and equatorial regions as well as between the trailing and leading hemispheres. As impinging ions sputter surface constituents as neutrals, ion precipitation patterns can be remotely imaged using the Energetic Neutral Atoms (ENA) measurement technique. Here we calculate the expected sputtered ENA flux from the surface of Ganymede to help interpret future observations by ENA instruments, particularly the Jovian Neutrals Analyzer (JNA) onboard the JUpiter ICy moon Explorer (JUICE) spacecraft. We use sputtering models developed based on laboratory experiments to calculate sputtered fluxes of H2O, O2, and H2. The input ion population used in this study is the result of test particle simulations using electric and magnetic fields from a hybrid simulation of Ganymede's environment. This population includes a thermal component (H+ and O+ from 10 eV to 10 keV) and an energetic component (H+, O++, and S+++ from 10 keV to 10 MeV). We find a global ENA sputtering rate from Ganymede of 1.42 × 1027 s−1, with contributions from H2, O2, and H2O of 34%, 17%, and 49% respectively. We also calculate the energy distribution of sputtered Energetic Neutral Atoms (ENAs), give an estimate of a typical JNA count rate at Ganymede, and investigate latitudinal variations of sputtered fluxes along a simulated orbit track of the JUICE spacecraft. Our results demonstrate the capability of the JNA sensor to remotely map ion precipitation at Ganymede.
Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia
Authors: Yang Erna , Guan Wei , Gong Desheng , Li Jieying , Han Caixia , Zhang Juan , Wang Hong , Kang Synat , Gao Xuefeng , Li Yonghui , Yu Li 
Published: December 2021

AbstractThe formation of the RUNX1-RUNX1T1 fusion protein, resulting from the t(8;21) translocation, is considered to be one of the initiating events of t(8;21) acute myeloid leukemia (AML). However, the mechanisms of the oncogenic mechanism of RUNX1-RUNX1T1 remain unclear. In this study, we found that RUNX1-RUNX1T1 triggers the heterochromatic silencing of UBXN8 by recognizing the RUNX1-binding sites and recruiting chromatin-remodeling enzymes to the UBXN8 promoter region. Decitabine, a specific inhibitor of DNA methylation, upregulated the expression of UBXN8 in RUNX1-RUNX1T1+ AML cell lines. Overexpression of UBXN8 inhibited the proliferation and colony-forming ability of and promoted cell cycle arrest in t(8;21) AML cell lines. Enhancing UBXN8 levels can significantly inhibit tumor proliferation and promote the differentiation of RUNX1-RUNX1T1+ cells in vivo. In conclusion, our results indicated that epigenetic silencing of UBXN8 via methylation of its promoter region mediated by the RUNX1-RUNX1T1 fusion protein contributes to the leukemogenesis of t(8;21) AML and that UBXN8 targeting may be a potential therapeutic strategy for t(8;21) AML.
Understanding dental caries as a non-communicable disease
Authors: Pitts Nigel B. , Twetman Svante , Fisher Julian , Marsh Philip D. 
Published: December 2021

AbstractThe recent developments in the science underpinning our knowledge of both the initiation of dental caries and the subsequent behaviour of lesions over time gives us a solid base to understand caries differently. Advances in understanding the human and oral microbiome have come in parallel with the recognition of the importance of balancing protective and pathological risk factors. Caries prevention and management is now about controlling risk factors to maintain a balanced intraoral biofilm ecology that guards against a continuing low pH driven by the frequent consumption of sugars. Thus, caries control is no longer about attempts at eradicating any specific microorganism. Further, the present knowledge leads to the classification of dental caries as a non-communicable disease (NCD), which is vitally important from a policy perspective (both globally and at the country level). Caries shares similar risk factors with other chronic/systemic diseases, which provides opportunities for developing common prevention strategies and promoting health equity through action on the social determinants of health. So, preventing and controlling caries should be integrated across the so-called upstream, midstream and downstream levels and these activities can also help to control other NCDs.
Sources of confidence in value-based choice
Authors: Brus Jeroen , Aebersold Helena , Grueschow Marcus , Polania Rafael 
Published: December 2021

AbstractConfidence, the subjective estimate of decision quality, is a cognitive process necessary for learning from mistakes and guiding future actions. The origins of confidence judgments resulting from economic decisions remain unclear. We devise a task and computational framework that allowed us to formally tease apart the impact of various sources of confidence in value-based decisions, such as uncertainty emerging from encoding and decoding operations, as well as the interplay between gaze-shift dynamics and attentional effort. In line with canonical decision theories, trial-to-trial fluctuations in the precision of value encoding impact economic choice consistency. However, this uncertainty has no influence on confidence reports. Instead, confidence is associated with endogenous attentional effort towards choice alternatives and down-stream noise in the comparison process. These findings provide an explanation for confidence (miss)attributions in value-guided behaviour, suggesting mechanistic influences of endogenous attentional states for guiding decisions and metacognitive awareness of choice certainty.
Enhancement of drought tolerance in diverse Vicia faba cultivars by inoculation with plant growth-promoting rhizobacteria under newly reclaimed soil conditions
Authors: Mansour Elsayed , Mahgoub Hany A. M. , Mahgoub Samir A. , El-Sobky El-Sayed E. A. , Abdul-Hamid Mohamed I. , Kamara Mohamed M. , AbuQamar Synan F. , El-Tarabily Khaled A. , Desoky El-Sayed M. 
Published: December 2021

AbstractWater deficit has devastating impacts on legume production, particularly with the current abrupt climate changes in arid environments. The application of plant growth-promoting rhizobacteria (PGPR) is an effective approach for producing natural nitrogen and attenuating the detrimental effects of drought stress. This study investigated the influence of inoculation with the PGPR Rhizobium leguminosarum biovar viciae (USDA 2435) and Pseudomonas putida (RA MTCC5279) solely or in combination on the physio-biochemical and agronomic traits of five diverse Vicia faba cultivars under well-watered (100% crop evapotranspiration [ETc]), moderate drought (75% ETc), and severe drought (50% ETc) conditions in newly reclaimed poor-fertility sandy soil. Drought stress substantially reduced the expression of photosynthetic pigments and water relation parameters. In contrast, antioxidant enzyme activities and osmoprotectants were considerably increased in plants under drought stress compared with those in well-watered plants. These adverse effects of drought stress reduced crop water productivity (CWP) and seed yield‐related traits. However, the application of PGPR, particularly a consortium of both strains, improved these parameters and increased seed yield and CWP. The evaluated cultivars displayed varied tolerance to drought stress: Giza-843 and Giza-716 had the highest tolerance under well-watered and moderate drought conditions, whereas Giza-843 and Sakha-4 were more tolerant under severe drought conditions. Thus, co-inoculation of drought-tolerant cultivars with R. leguminosarum and P. putida enhanced their tolerance and increased their yield and CWP under water-deficit stress conditions. This study showed for the first time that the combined use of R. leguminosarum and P. putida is a promising and ecofriendly strategy for increasing drought tolerance in legume crops.
Different increase rate in body mass of two marten species due to climate warming potentially reinforces interspecific competition
Authors: Wereszczuk Anna , Hofmeester Tim R. , Csanády Alexander , Dumić Tomislav , Elmeros Morten , Lanszki József , Madsen Aksel B. , Müskens Gerard , Papakosta Malamati A. , Popiołek Marcin , Santos-Reis Margarida , Zuberogoitia Iñigo , Zalewski Andrzej 
Published: December 2021

AbstractMany species show spatial variation in body size, often associated with climatic patterns. Studying species with contrasting geographical patterns related to climate might help elucidate the role of different drivers. We analysed changes in the body mass of two sympatric medium-sized carnivores—pine marten (Martes martes) and stone marten (Martes foina)—across Europe over 59 years. The body mass of pine marten increased with decreasing latitude, whereas stone marten body mass varied in a more complex pattern across its geographic range. Over time, the average body mass of pine martens increased by 255 g (24%), while stone marten by 86 g (6%). The greatest increase of body mass along both martens’ geographic range was observed in central and southern Europe, where both species occur in sympatry. The body mass increase slowed down over time, especially in allopatric regions. The average pine/stone marten body mass ratio increased from 0.87 in 1960 to 0.99 in 2019, potentially strengthening the competition between them. Thus, a differential response in body size to several drivers over time might have led to an adaptive advantage for pine martens. This highlights the importance of considering different responses among interacting species when studying animal adaptation to climate change.
Overexpression of chalcone isomerase A gene in Astragalus trigonus for stimulating apigenin
Authors: Elarabi Nagwa I. , Abdelhadi Abdelhadi A. , Sief-Eldein Ahmed G. M. , Ismail Ismail A. , Abdallah Naglaa A. 
Published: December 2021

AbstractApigenin is one of the most studied flavonoids and is widely distributed in the plant kingdom. Apigenin exerts important antioxidant, antibacterial, antifungal, antitumor activities, and anti-inflammatory effects in neurological or cardiovascular disease. Chalcone isomerase A (chiA) is an important enzyme of the flavonoid biosynthesis pathway. In order to enhance the apigenin production, the petunia chi A gene was transformed for Astragalus trigonus. Bialaphos survived plants were screened by PCR, dot blot hybridization and RT-PCR analysis. Also, jasmonic acid, salicylic acid, chitosan and yeast extract were tested to evaluate their capacity to work as elicitors for apigenin. Results showed that yeast extract was the best elicitor for induction of apigenin with an increase of 3.458 and 3.9 fold of the control for calli and cell suspension culture, respectively. Transformed cell suspension showed high apigenin content with a 20.17 fold increase compared to the control and 6.88 fold more than the yeast extract treatment. While, transformed T1 calli derived expressing chiA gene produced apigenin 4.2 fold more than the yeast extract treatment. It can be concluded that the highest accumulation of apigenin was obtained with chiA transgenic cell suspension system and it can be utilized to enhancement apigenin production in Astragalus trigonus.
Microstructure of the fluid particles around the rigid body at the shear-thickening state toward understanding of the fluid mechanics
Authors: Jono Ryota , Tejima Syogo , Fujita Jun-ichi 
Published: December 2021

AbstractWe studied the shear-thickening behavior of systems containing rigid spherical bodies immersed in smaller particles using non-equilibrium molecular dynamics simulations. We generated shear-thickening states through particle mass modulation of the systems. From the microstructures, i.e., two-dimensional pair distribution functions, we found anisotropic structures resulting from shear thickening, that are explained by the difference between the velocities of rigid bodies and fluid particles. The increasing viscosity in our system originated from collisions between fluid particles and rigid bodies. The lubrication forces defined in macroscale physics are then briefly discussed.
Abnormal transaminase and lipid profiles in coexisting diseases in patients with fatty liver: a population study in Sichuan
Authors: Jiang Wei , Liu Chang-hai , Wu Dongbo , Wang You-Juan , Tang Hong 
Published: December 2021

Abstract
Among chronic liver diseases, fatty liver has the highest incidence worldwide. Coexistence of fatty liver and other chronic diseases, such as diabetes, hepatitis B virus (HBV) and Helicobacter pylori (Hp) infection, is common in clinical practice. The present study was conducted to analyze the prevalence and association of coexisting diseases in patients with fatty liver and to investigate how coexisting diseases contribute to abnormal transaminase and lipid profiles. We enrolled participants who were diagnosed with fatty liver via ultrasound in the physical examination center of West China Hospital. Multivariable logistic regression was used to determine the adjusted odds ratios (ORs). We found that 23.6% of patients who underwent physical examinations were diagnosed with fatty liver. These patients had higher risks of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and hypertension and a lower risk of HBV infection. The risks of Hp infection and hyperthyroidism did not statistically differ. When fatty liver coexisted with T2DM, MetS and thyroid dysfunction, it conferred a higher risk of elevated transaminase. Fatty liver was positively correlated with triglycerides, cholesterol and low-density lipoprotein cholesterol (LDL-C) and negatively correlated with HBV; thus, HBV had a neutralizing effect on lipid metabolism when coexisting with fatty liver. In conclusion, patients with fatty liver that coexists with T2DM, MetS and thyroid dysfunction are more prone to elevated transaminase levels. Patients with both fatty liver and HBV may experience a neutralizing effect on their lipid metabolism. Thus, lipid alterations should be monitored in these patients during antiviral treatment for HBV.
DOA estimation of the quasi‐stationary signal using sparse reconstruction
Authors: Wu Fan , Cao Fei , Zhang Xurong , Lu Shikun , Zhang Yanhong 
Published: December 2021

AbstractGiven the problem of the direction of arrival (DOA) estimation of quasi‐stationary signals, a sparse reconstruction algorithm based on the sparse array is proposed in this study to improve the DOA estimation performance. Specifically, the quasi‐stationary signal is modelled based on the interleaved array (IA), where the algorithm makes full use of the high degree of freedom (DOF) and large array aperture of the interleaved array in the virtual domain. Then, the angle parameters are estimated depending on sparse reconstruction and the Khatri‐Rao transform, which can achieve a higher number of DOF. Compared with the angle measurement algorithm based on uniform linear array and nested linear array, the algorithm proposed in this study not only increases the DOF of angle measurement significantly, but also improves the accuracy of angle measurement. Finally, numerical simulations demonstrate the validity of the proposed method.
Detection of Cerebrospinal Fluid Leaks Using the Endoscopic Fluorescein Test in the Postoperative Period following Pituitary and Ventral Skull Base Surgery
Authors: Benedict Peter A. , Connors Joseph R. , Timen Micah R. , Bhatt Nupur , Lebowitz Richard A. , Pacione Donato R. , Lieberman Seth M. 
Published: December 2021

Abstract
Objective Diagnosis of cerebrospinal fluid (CSF) leaks is sometimes challenging in the postoperative period following pituitary and ventral skull base surgery. Intrathecal fluorescein (ITF) may be useful in this setting.
Design Retrospective chart review.
Setting Tertiary care center.
Methods and Participants All patients who underwent pituitary and ventral skull base surgery performed by a single rhinologist between January 2017 and March 2020 were included. There were 103 patients identified. Eighteen patients received 20 ITF injections due to clinical suspicion for CSF leak during the postoperative period without florid CSF rhinorrhea on clinical exam. Computed tomography scans with new or increasing intracranial air and intraoperative findings were used to confirm CSF leaks. Clinical courses were reviewed for at least 6 months after initial concern for leak as the final determinate of CSF leak.
Main Outcome Measures Specificity and safety of ITF.
Results Eleven (61%) ITF patients were female and 7 (39%) were male. Average patient age was 52.50 ± 11.89. There were six patients with confirmed postoperative CSF leaks, 3 of whom had evaluations with ITF. ITF use resulted in 2 true positives, 1 false negative, 17 true negatives, and 0 false positives. ITF sensitivity was 67%, specificity was 100%, and positive and negative predictive values were 100 and 94.4%, respectively. There were no adverse effects from ITF use.
Conclusions Existing modalities for detecting postoperative CSF leaks suffer from suboptimal sensitivity and specificity, delayed result reporting, or limited availability. ITF represents a specific and safe test with potential utility in the postoperative setting.
Anatomical Step-by-Step Dissection of Complex Skull Base Approaches for Trainees: Endoscopic Endonasal Approach to the Orbit
Authors: Salgado-Lopez Laura , Leonel Luciano C. P. C. , O'brien Michael , Adepoju Adedamola , Graffeo Christopher S. , Carlstrom Lucas P. , Link Michael J. , Pinheiro-Neto Carlos D. , Peris-Celda Maria 
Published: December 2021

Abstract
Introduction Although endonasal endoscopic approaches (EEA) to the orbit have been previously reported, a didactic resource for educating neurosurgery and otolaryngology trainees regarding the pertinent anatomy, techniques, and decision-making pearls is lacking.
Methods Six sides of three formalin-fixed, color latex–injected cadaveric specimens were dissected using 4-mm 0- and 30-degree rigid endoscopes, as well as standard endoscopic equipment, and a high-speed surgical drill. The anatomical dissection was documented in stepwise three-dimensional (3D) endoscopic images. Following dissection, representative case applications were reviewed.
Results EEA to the orbit provides excellent access to the medial and inferior orbital regions. Key steps include positioning and preoperative considerations, middle turbinate medialization, uncinate process and ethmoid bulla removal, complete ethmoidectomy, sphenoidotomy, maxillary antrostomy, lamina papyracea resection, orbital apex and optic canal decompression, orbital floor resection, periorbita opening, dissection of the extraconal fat, and final exposure of the orbit contents via the medial-inferior recti corridor.
Conclusion EEA to the orbit is challenging, in particular for trainees unfamiliar with nasal and paranasal sinus anatomy. Operatively oriented neuroanatomy dissections are crucial didactic resources in preparation for practical endonasal applications in the operating room (OR). This approach provides optimal exposure to the inferior and medial orbit to treat a wide variety of pathologies. We describe a comprehensive step-by-step curriculum directed to any audience willing to master this endoscopic skull base approach.
Local Anesthesia and Conscious Sedation Does Not Affect Patient's Mood and Anxiety Levels during Percutaneous Endoscopic Lumbar Diskectomy: A Prospective Study
Authors: Erken H. Yener , Karaeminogullari Oguz , Yilmaz Onur , Mirel Kerem , Ozer R. Ozgur 
Published: December 2021

Abstract
Background and Study Aims Undergoing a surgical procedure can be very stressful for patients and can lead to high anxiety levels during both the preoperative and the postoperative period. Levels of anxiety and fear may depend on multiple factors including the type of anesthesia to be used. The objective of this study is to evaluate whether patient's awareness of the surgical environment in the operating room under local anesthesia and conscious sedation (LACS) affects their mood and anxiety levels.
Methods We performed a prospective study for a series of consecutive patients who underwent transforaminal percutaneous endoscopic lumbar diskectomy (PELD) for the treatment of lumbar disk herniation. The patients completed Profile of Mood States (POMS) and State-Trait Anxiety Inventory (STAI) forms in the preoperative period and in the early postoperative period. We divided the patients into two groups according to the type of anesthesia applied during surgery: LACS and general anesthesia (GA) groups. We compared the preoperative and postoperative POMS and STAI scores between groups and the change of these scores between the preoperative and postoperative periods in each group.
Results In this study, we included 30 patients who underwent PELD between May and December 2019 and met the inclusion criteria. The GA group consisted of 16 patients and the LACS group consisted of 14 patients. In each group, POMS and STAI scores decreased in the early postoperative period compared with the preoperative period. We found no significant difference in percentage of POMS and STAI TX-1 score changes between the LACS and GA groups.
Conclusion The results of our study show that patients' awareness of the surgical environment in the operating room under LACS does not significantly affect their mood and anxiety levels and patients do not seem to endure increased emotional stress during the PELD operation, as compared with PELD operation under GA.