bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Equivalence of GGTA-1 Glycosyltransferase Knockout and Standard Porcine Pericardial Tissue Using 90-Day Mitral Valve Implantation in Adolescent Sheep
Authors: McGregor Christopher , Salmonsmith Jacob , Burriesci Gaetano , Byrne Guerard 
Published: November 2021

Abstract
Objective
There is growing interest in the application of genetically engineered reduced antigenicity animal tissue for manufacture of bioprosthetic heart valves (BHVs) to reduce antibody induced tissue calcification and accelerated structural valve degeneration (SVD). This study tested biological equivalence of valves made from Gal-knockout (GalKO) and standard porcine pericardium after 90-day mitral valve implantation in sheep.

Methods
GalKO (n = 5) and standard (n = 5) porcine pericardial BHVs were implanted in a randomized and blind fashion into sheep for 90-days. Valve haemodynamic function was measured at 30-day intervals. After explantation, valves were examined for pannus, vegetation, inflammation, thrombus, and tissue calcification.

Results
Nine of 10 recipients completed the study. There was no difference between study groups for haemodynamic performance and no adverse valve-related events. Explanted BHVs showed mild pannus integration and minimal thrombus, with no difference between the groups. Limited focal mineral deposits were detected by x-ray. Atomic spectroscopy analysis detected tissue calcium levels of 1.0 µg/mg ± 0.2 for GalKO BHVs and 1.9 µg/mg ± 0.9 for standard tissue BHVs (p = 0.4), considered to be both low and equivalent.

Conclusions
This is the first demonstration of biological equivalence between GalKO and standard pig pericardium. The GalKO mutation causes neither intrinsic detrimental biological nor functional impact on BHV performance. Commercial adaptation of GalKO tissue for surgical or transcatheter BHVs would remove the clinical disparity between patients producing anti-Gal antibody and BHVs containing the Gal antigen. GalKO BHVs may reduce accelerated tissue calcification and SVD, enhancing patient choices, especially for younger patients.

Graphical Abstract
Coherent Precipitates as a Condition for Ultra-Low Fatigue in Cu-Rich Ti53.7Ni24.7Cu21.6 Shape Memory Alloys
Authors: Bumke L. , Wolff N. , Chluba C. , Dankwort T. , Kienle L. , Quandt E. 
Published: November 2021

AbstractSputtered Ti–rich TiNiCu alloys are known to show excellent cyclic stability. Reversibility is mostly influenced by grain size, crystallographic compatibility and precipitates. Isolating their impact on cyclic stability is difficult. Ti2Cu precipitates for instance are believed to enhance reversibility by showing a dual epitaxy with the B2 and B19 lattice. Their influence on the functional fatigue, if they partly lose the coherency is still unknown. In this study, sputtered Ti53.7Ni24.7Cu21.6 films have been annealed at different temperatures leading to a similar compatibility (λ2 ~ 0.99), grain size and thermal cyclic stability. Films annealed at 550 °C exhibit a superior superelastic fatigue resistance but with reduced transformation temperatures and enthalpies. TEM investigations suggest the formation of Guinier–Preston (GP) zone-like plate precipitates and point towards a coherency relation of the B2 phase and finely distributed Ti2Cu precipitates (~ 60 nm). Films annealed at 700 °C result in the growth of Ti2Cu precipitates (~ 280 nm) with an irregular distribution and a partial loss of their coherency. Thus, GP zones are assumed to cause the reduction of transformation temperatures and enthalpies due to increased internal stresses, whereas the coherency relation of both, Ti2Cu and GP zones, help to increase the superelastic stability, well beyond 107 cycles.
Aotearoa New Zealand’s New National History Curriculum and Histories of Mourning
Authors: Bell Avril , Russell Elizabeth 
Published: November 2021

AbstractFrom 2022, New Zealand schools are teaching a new compulsory history curriculum that aims to teach diverse New Zealand histories, while foregrounding the centrality of Māori histories and the impacts of colonisation. The new curriculum will upend a long history of ‘forgetting’ the nation’s contentious and conflictual past, and in particular the nineteenth century ‘wars for New Zealand’ (O’Malley, 2016) that secured settler hegemony over the nation-state. In this paper, we focus on the roles of remembering and forgetting in the narration of national histories to explore what might be a productive orientation to take to this contentious and unsettling past. We argue that the new history curriculum inaugurates a new phase of narrating the nation, replacing earlier phases of monocultural and bicultural nationhood that depended on this past being ‘forgotten’. And we argue for the productive value of a histories of critical mourning approach to remembering this founding violence.
Die Abbildung von Wirkungen beruflicher Weiterbildung in der Bildungsberichterstattung: Bestand und Perspektiven
Authors: Echarti Nicolas , Reichart Elisabeth , Gerhards Pia 
Published: November 2021

ZusammenfassungDieser Beitrag nimmt eine Bestandsaufnahme der indikatorenbasierten Darstellung der Wirkungen beruflicher Weiterbildung in der nationalen Bildungsberichterstattung vor. Dafür werden Wirkungsdimensionen in einer Wirkungskette systematisiert und die Teilbereiche beruflicher Weiterbildung abgegrenzt. Die Analyse relevanter nationaler Berichte zeigt auf, dass die Teilbereiche sehr uneinheitlich abgedeckt sind und überwiegend öffentlich geförderte Weiterbildungsmaßnahmen dargestellt werden. Es dominieren deskriptive Kennziffern zu kurz- und mittelfristigen Bildungserfolgen und -ergebnissen. In den analysierten Berichten liegen hingegen nur wenige analytische Kennziffern und keine Kennziffern zu langfristigen Bildungserträgen vor. Perspektiven der Weiterentwicklung liegen sowohl in einer verbesserten Datennutzung als auch auf konzeptioneller Ebene der Bildungsberichterstattung.
A network-based group testing strategy for colleges
Authors: Zhao Alex , Kumaravel Kavin , Massaro Emanuele , Gonzalez Marta 
Published: November 2021

AbstractGroup testing has recently become a matter of vital importance for efficiently and rapidly identifying the spread of Covid-19. In particular, we focus on college towns due to their density, observability, and significance for school reopenings. We propose a novel group testing strategy which requires only local information about the underlying transmission network. By using cellphone data from over 190,000 agents, we construct a mobility network and run extensive data-driven simulations to evaluate the efficacy of four different testing strategies. Our results demonstrate that our group testing method is more effective than three other baseline strategies for reducing disease spread with fewer tests.
»Ein echter Naturforscher von heute hat eine tiefe Verachtung gegen ›Literatur‹«
Authors: Gronau Magdalena , Gronau Martin 
Published: November 2021

ZusammenfassungDer vorliegende Aufsatz beleuchtet die komplexen Wechselbeziehungen zwischen Physik, Literatur und Philologie in der ersten Hälfte des 20. Jahrhunderts. Ausgehend von einem Brief des österreichischen Physikers Erwin Schrödinger an Ernst Cassirer gehen wir der Frage nach, inwiefern die prominenten deutschsprachigen Vertreter der aufstrebenden theoretischen Physik nicht nur literarische Texte und Inhalte verarbeiteten, sondern in ihrer zutiefst philologisch geprägten Publikations- und Arbeitspraxis auch textwissenschaftlich operierten. Lassen sich in den nachgelassenen und publizierten Schriften von Physikern wie Schrödinger neue Hinweise darauf finden, dass die »Macht der Philologie« noch weit ins Jahrhundert der Physik nachwirken, ja Philologie vielleicht sogar als Wissensmodell in der theoretischen Physik fungieren konnte?
AUV localisation: a review of passive and active techniques
Authors: Maurelli Francesco , Krupiński Szymon , Xiang Xianbo , Petillot Yvan 
Published: November 2021

AbstractLocalisation, i.e. estimation of one’s position in a given environment is a crucial element of many mobile systems, manned and unmanned. Due to the high demand for autonomous exploration, patrolling and inspection services and a rapid improvement of batteries, sensors and machine learning algorithms, the quality of localisation becomes even more important for smart robotic systems. The underwater domain is a very challenging environment due to the water blocking most of the signals over short distances. Recent results in localisation techniques for underwater vehicles are summarised in two principal categories: passive techniques, which strive to provide the best estimation of the vehicle’s position (global or local) given the past and current information from sensors, and active techniques, which additionally produce guidance output that is expected to minimise the uncertainty of estimated position.
Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
Authors: Sampson Kaylie , Koo Songmi , Gadola Carter , Vasiukhina Anastasiia , Singh Aditya , Spartano Alexandra , Gollapudi Rachana , Duley Matthew , Mueller Jens , James Paul F. , Yousefi Amy M. 
Published: November 2021

AbstractThe use of porous 3D scaffolds for the repair of bone nonunion and osteoporotic bone is currently an area of great interest. Using a combination of thermally-induced phase separation (TIPS) and 3D-plotting (3DP), we have generated hierarchical 3DP/TIPS scaffolds made of poly(lactic-co-glycolic acid) (PLGA) and nanohydroxyapatite (nHA). A full factorial design of experiments was conducted, in which the PLGA and nHA compositions were varied between 6‒12% w/v and 10‒40% w/w, respectively, totaling 16 scaffold formulations with an overall porosity ranging between 87%‒93%. These formulations included an optimal scaffold design identified in our previous study. The internal structures of the scaffolds were examined using scanning electron microscopy and microcomputed tomography. Our optimal scaffold was seeded with MC3T3-E1 murine preosteoblastic cells and subjected to cell culture inside a tissue culture dish and a perfusion bioreactor. The results were compared to those of a commercial CellCeram™scaffold with a composition of 40% β-tricalcium phosphate and 60% hydroxyapatite (β-TCP/HA). Media flow within the macrochannels of 3DP/TIPS scaffolds was modeled in COMSOL software in order to fine tune the wall shear stress. CyQUANT DNA assay was performed to assess cell proliferation. The normalized number of cells for the optimal scaffold was more than twofold that of CellCeram™scaffold after two weeks of culture inside the bioreactor. Despite the substantial variability in the results, the observed improvement in cell proliferation upon culture inside the perfusion bioreactor (vs. static culture) demonstrated the role of macrochannels in making the 3DP/TIPS scaffolds a promising candidate for scaffold-based tissue engineering.
Provable Data Possession (PDP) and Proofs of Retrievability (POR) of Current Big User Data
Authors: Walker Ieuan , Hewage Chaminda , Jayal Ambikesh 
Published: November 2021

AbstractA growing trend over the last few years is storage outsourcing, where the concept of third-party data warehousing has become more popular. This trend prompts several interesting privacy and security issues. One of the biggest concerns with third-party data storage providers is accountability. This article, critically reviews two schemas/algorithms that allow users to check the integrity and availability of their outsourced data on untrusted data stores (i.e., third-party data storages). The reviewed schemas are provable data possession (PDP) and proofs of retrievability (POR). Both are cryptographic protocols designed to provide clients the assurance that their data are secure on the untrusted data storages. Furthermore, a conceptual framework is proposed to mitigate the weaknesses of the current storage solutions.
Therapeutic Effects of Microsurgical Clipping at Different Time Points on Intracranial Aneurysm and Prognostic Factors
Authors: Huang Ge , Sun Yang , Li Jinhong , Xie Zhengyuan , Tong Xiaoguang 
Published: November 2021

Abstract
Background
Microsurgical clipping is effective for treating early rupture hemorrhage in intracranial aneurysm (IA) patients. We aimed to evaluate the therapeutic effects of microsurgical clipping at different time points on IA and to explore prognostic factors.

Methods
A total of 102 eligible patients were divided into good prognosis group (n = 87) and poor prognosis group (n = 15) according to Glasgow Outcome Scale (GOS) scores at discharge. The effects of microsurgical clipping at different time points (within 24 h, 48 h and 72 h) were compared. The incidence rates of postoperative complications in patients with different Hunt–Hess grades were compared. Prognostic factors were determined by multivariate logistic regression analysis. The nomogram prediction model was established based on independent risk factors and validated.

Results
The good recovery and success rates of complete aneurysm clipping were significantly higher in patients undergoing surgery within 24 h after rupture. The incidence rate of complications was significantly higher in patients with Hunt–Hess grade IV. Good and poor prognosis groups had significantly different age, history of hypertension, preoperative intracranial hematoma volume, aneurysm size, preoperative Hunt–Hess grade, later surgery, postoperative complications and National Institute of Health Stroke Scale (NIHSS) score, as independent risk factors for prognosis. The nomogram model predicted that poor prognosis rate was 14.71%.

Conclusion
Timing (within 24 h after rupture) microsurgical clipping benefits the prognosis of IA patients. Age, history of hypertension, preoperative intracranial hematoma volume, aneurysm size, preoperative Hunt–Hess grade, later surgery, postoperative complications and NIHSS score are independent risk factors for poor prognosis.
MicroRNA-320a-3p Signatures as a Satisfactory Predictor of Acute Coronary Syndrome and Attenuates Inflammation by Targeting X-Linked Inhibitor of Apoptosis Protein
Authors: Zhang Yong , Zhang Zhen , Zhang Aiyuan 
Published: November 2021

AbstractAcute coronary syndrome (ACS) is a heart disease with a high mortality rate. Recently, more and more evidence illustrated that microRNAs (miRNA) participated in regulating the occurrence of heart disease. This study aimed to detect the level of serum miR-320a-3p in patients with ACS, predict its possibility as a candidate gene for diagnosis, and explore its potential mechanism in the regulation of ACS. 139 ACS patients and 126 controls were recruited in this study. The expression level of miR-320a-3p was determined by qRT-PCR. The predictive value in ACS was assessed by receiver operating characteristic (ROC) curve. Enzyme-linked immunosorbent assay (ELISA) was used to measure the protein expression levels of inflammatory factors. The downstream targets of miR-320a-3p were verified by luciferase reporter gene assay. In ACS patients and rat models, the expression level of serum miR-320a-3p was significantly increased. ROC curve revealed that abnormal expression of miR-320a-3p was of diagnostic value for ACS. In an in vivo rat model, down-regulation of miR-320a-3p inhibited the production of von Willebrand factor (vWF), Heart fatty acid-binding protein (H-FABP), interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α). In other words, down-regulation of miR-320a-3p reduced rat vascular endothelial injury and inflammation. X-linked inhibitor of apoptosis protein (XIAP) was determined to be a direct target of miR-320a-3p. miR-320a-3p is useful for the diagnosis of ACS. Animal experiments confirmed that up-regulated miR-320a-3p promoted vascular endothelial injury and inflammatory response by targeting XIAP, thus promoting the development of ACS. MiR-320a-3p may be a new breakthrough in the diagnosis and treatment of ACS.
Considerations for Post-processing Parameters in Mixed-Method 3D Analyses
Authors: Selden Robert Z. , Butaric Lauren N. , Bergstrom Kersten , Van Gerven Dennis 
Published: November 2021

ABSTRACTThe production of three-dimensional (3D) digital meshes of surface and computed tomographic (CT) data has become widespread in morphometric analyses of anthropological and archaeological data. Given that processing methods are not standardized, this leaves questions regarding the comparability of processed and digitally curated 3D datasets. The goal of this study was to identify those processing parameters that result in the most consistent fit between CT-derived meshes and a 3D surface model of the same human mandible. Eight meshes, each using unique thresholding and smoothing parameters, were compared to assess whole-object deviations, deviations along curves, and deviations between specific anatomical features on the surface model when compared with the CT scans using a suite of comparison points. Based on calculated gap distances, the mesh that thresholded at “0” with an applied smoothing technique was found to deviate least from the surface model, although it is not the most biologically accurate. Results have implications for aggregated studies that employ multimodal 3D datasets, and caution is recommended for studies that enlist 3D data from websites and digital repositories, particularly if processing parameters are unknown or derived for studies with different research foci.
The sources of military dissent: Why and how the US military contests civilian decisions about the use of force
Authors: Brooks Risa , Erickson Peter M. 
Published: November 2021

AbstractHow do militaries push back when they oppose civilian initiatives? This article analyses the sources and character of military dissent, focusing on the United States. It details the sources of military preferences over policy and strategy outcomes, emphasising the interplay of role conceptions with other material and ideational factors. It then presents a repertoire of means – tactics of dissent – through which military leaders can exert pressure, constraining and shaping civilians’ decision-making calculus and the implementation of policy and strategy choices. Empirically, it traces military dissent in the 1990s-era humanitarian interventions; the US's ‘War on Drugs’ beginning in the 1980s; and the Afghanistan surge debate in 2009. In so doing, the article contributes to a broader research programme on military dissent across regime types. It also expands scholars’ understandings of preference formation within militaries and illuminates the various pathways through which military dissent operates and potentially undermines civilian control.
Divergent effects of sex and calcium/vitamin D supplementation on serum magnesium and markers of bone structure and function during initial military training
Authors: Hennigar Stephen R. , Kelley Alyssa M. , Nakayama Anna T. , Anderson Bradley J. , McClung James P. , Gaffney-Stomberg Erin 
Published: November 2021

AbstractMaintaining Mg status may be important for military recruits, a population that experiences high rates of stress fracture during initial military training (IMT). The objectives of this secondary analysis were to (1) compare dietary Mg intake and serum Mg in female and male recruits pre- and post-IMT, (2) determine whether serum Mg was related to parameters of bone health pre-IMT, and (3) whether Ca and vitamin D supplementation (Ca/vitamin D) during IMT modified serum Mg. Females (n 62) and males (n 51) consumed 2000 mg of Ca and 25 μg of vitamin D/d or placebo during IMT (12 weeks). Dietary Mg intakes were estimated using FFQ, serum Mg was assessed and peripheral quantitative computed tomography was performed on the tibia. Dietary Mg intakes for females and males pre-IMT were below the estimated average requirement and did not change with training. Serum Mg increased during IMT in females (0·06 ± 0·08 mmol/l) compared with males (–0·02 ± 0·10 mmol/l; P < 0·001) and in those consuming Ca/vitamin D (0·05 ± 0·09 mmol/l) compared with placebo (0·001 ± 0·11 mmol/l; P = 0·015). In females, serum Mg was associated with total bone mineral content (BMC, β = 0·367, P = 0·004) and robustness (β = 0·393, P = 0·006) at the distal 4 % site, stress–strain index of the polaris axis (β = 0·334, P = 0·009) and robustness (β = 0·420, P = 0·004) at the 14 % diaphyseal site, and BMC (β = 0·309, P = 0·009) and stress–strain index of the polaris axis (β = 0·314, P = 0·006) at the 66 % diaphyseal site pre-IMT. No significant relationships between serum Mg and bone measures were observed in males. Findings suggest that serum Mg may be modulated by Ca/vitamin D intake and may impact tibial bone health during training in female military recruits.
Effect of black soldier fly (Hermetia illucens) larvae meal on lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei
Authors: Chen Yongkang , Chi Shuyan , Zhang Shuang , Dong Xiaohui , Yang Qihui , Liu Hongyu , Tan Beiping , Xie Shiwei 
Published: November 2021

AbstractThe present study investigated the effect of black soldier fly (Hermetia illucens) larvae meal (BSF) on haemolymph biochemical indicators, muscle metabolites as well as the lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei. Four diets were formulated in which the control diet contained 25 % of fishmeal (FM) and 10 % (BSF10), 20 % (BSF20), and 30 % (BSF30) of FM protein were replaced with BSF. Four hundred and eighty shrimp (0·88 ± 0·00 g) were distributed to four groups of three replicates and fed for 7 weeks. Results showed that growth performance of shrimp fed BSF30 significantly decreased compared with those fed FM, but there was no significant difference in survival among groups. The whole shrimp crude lipid content, haemolymph TAG and total cholesterol were decreased with the increasing BSF inclusion. The results of metabolomics showed that the metabolite patterns of shrimp fed different diets were altered, with significant changes in metabolites related to lipid metabolism, glucose metabolism as well as TCA cycle. The mRNA expressions of hk, pfk, pk, pepck, ampk, mcd, cpt-1 and scd1 in hepatopancreas were downregulated in shrimp fed BSF30, but mRNA expression of acc1 was upregulated. Unlike BSF30, the mRNA expressions of fas, cpt-1, fbp and 6pgd in hepatopancreas were upregulated in shrimp fed BSF20. This study indicates that BSF20 diet promoted lipid synthesis and lipolysis, while BSF30 diet weakened β-oxidation and glycolysis as well as affected the unsaturated fatty acids synthesis, which may affect the growth performance and body composition of shrimp.
Triassic calc-alkaline lamprophyre dykes from the North Qiangtang, central Tibetan Plateau: evidence for a subduction-modified lithospheric mantle
Authors: Liu Bin , Tang You-Jun , Xing Lü-Ya , Xu Yu , Zhao Shao-Qing , Sun Yang , Huang Jian 
Published: November 2021

AbstractPrimitive lamprophyres in orogenic belts can provide crucial insights into the nature of the subcontinental lithosphere and the relevant deep crust–mantle interactions. This paper reports a suite of relatively primitive lamprophyre dykes from the North Qiangtang, central Tibetan Plateau. Zircon U–Pb ages of the lamprophyre dykes range from 214 Ma to 218 Ma, with a weighted mean age of 216 ± 1 Ma. Most of the lamprophyre samples are similar in geochemical compositions to typical primitive magmas (e.g. high MgO contents, Mg no. values and Cr, with low FeOt/MgO ratios), although they might have experienced a slightly low degree of olivine crystallization, and they show arc-like trace-element patterns and enriched Sr–Nd isotopic composition ((87Sr/86Sr)i = 0.70538–0.70540, ϵNd(t) = −2.96 to −1.65). Those geochemical and isotopic variations indicate that the lamprophyre dykes originated from partial melting of a phlogopite- and spinel-bearing peridotite mantle modified by subduction-related aqueous fluids. Combining with the other regional studies, we propose that slab subduction might have occurred during Late Triassic time, and the rollback of the oceanic lithosphere induced the lamprophyre magmatism in the central Tibetan Plateau.