bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors of cardiovascular changes depending on the type and intensity of physical activity in professional athletes
Authors: Garganeeva N. P , Taminova I. F. , Kalyuzhin V. V. , Kalyuzhina E. V , Smirnova I. N. 
Published: November 2021

Aim. To determine the early predictive factors of cardiovascular changes in professional athletes, depending on the type and intensity of physical activity.Material and methods. A total of 136 male athletes were examined. Of these, 116 were professional athletes (age, 22,07±4,1 years) as follows: freestyle wrestling, judo (n=30), cross-country skiing, biathlon (n=27), powerlifting (n=33), volleyball (n=26). Control group included 20 athletes (age, 17,95±1,5 years) with a history of training less than 3 years. All participants underwent electrocardiography (ECG), echocardiography, cycle ergometry (CE) with assessment of physical performance at a heart rate of 170 bpm (PWC170) and maximum oxygen consumption (MOC). When creating predictive models of early cardiovascular changes, we used logistic regression, stepwise regression and Wald statistics. Differences were considered significant at p<0,05.Results. Predictive models of logistic regression using ROC analysis showed high sensitivity and specificity, a high percentage of correct predictions using data from echocardiography — 86,8%, CE — 80,9%, ECG and other indicators — 83,1%. A stepwise algorithm was used to select prognostic factors determining early cardiovascular changes in young athletes, depending on the stage of sports training, the intensity and type of dynamic and/or static exercise: left ventricular posterior wall thickness (p=0,008), left ventricular mass (p=0,001), stroke volume (p=0,002), end-systolic volume (p=0,001), PWC170 (p=0,025), MOC (p=0,003), recovery time of heart rate (HR) (p=0,029) and blood pressure (p=0,032) after submaximal exercise on a cycle ergometer, body mass index (p=0,029), heart rate (p=0,034), office systolic blood pressure (p=0,009), intraventricular (bundle) block (p=0,046), left ventricular repolarization abnormalities (p=0,010), mild cardiac connective tissue anomalies (p=0,035).Conclusion. The early prognostic factors established by the logistic regression affect the characteristics and risk of cardiovascular changes in each group of young athletes. This demonstrates the need to develop individual medical support programs, further monitoring, evaluation, correction and prevention of identified disorders, taking into account the type of sports, intensity and exercise.
Experience in genetic testing of hypertrophic cardiomyopathy using nanopore DNA sequencing
Authors: Salakhov R. R. , Golubenko M. V. , Pavlukova E. N. , Kucher A. N. , Babushkina N. P. , Valiahmetov N. R. , Markov A. V. , Belyaeva E. O. , Kanev A. F. , Nazarenko M. S. 
Published: November 2021

Aim. To investigate the application of the Oxford Nanopore Technologies’ third generation sequencing for the genetic testing of hypertrophic cardiomyopathy.Material and methods. The study involved 12 patients with hypertrophic cardiomyopathy aged 18 to 67 years (women, 9; men, 3). Using the PCR barcoding amplicons (SQK-LSK109) protocol, DNA libraries were created which contained long-range PCR fragments of the MYH7, MYBPC3, TNNT2, TNNI3 and TPM1 genes. The sequencing was performed using the MinION system by Oxford Nanopore Technologies (UK). Bioinformatic algorithms for data analysis included Guppy v.5.0.7, Nanopolish and Clairvoyante. The identified genetic variants were confirmed by Sanger sequencing.Results. Data on the complete sequence of the five major sarcomeric genes for hypertrophic cardiomyopathy were obtained. We found eight potentially disease-causing sequence variants in MYH7, MYBPC3 and TNNT2 genes by monomolecular sequencing. However, only three mutations p.Arg243Cys, p.Tyr609Asn, p.Arg870His in the MYH7 gene, and one mutation p.Lys985Asn in the MYBPC3 were confirmed by Sanger sequencing. Cascade screening of pathogenic variant p.Arg870His in the MYH7 gene was performed. We found one asymptomatic carrier.Conclusion. It appears that monomolecular sequencing technology is a feasible approach to identify mutations in patients with hypertrophic cardiomyopathy. Although improvement in accuracy of DNA sequencing, as well as optimization and simplification of bioinformatic algorithms for identification of the genetic variants are needed.
Spectrum of desmosomal gene variations in patients with arrhythmogenic right ventricular cardiomyopathy
Authors: Shestak A. G. , Blagova O. V. , Lutokhina Yu. A. , Dzemeshkevich S. L. , Zaklyazminskaya E. V. 
Published: November 2021

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary myocardial disease with a high risk of sudden cardiac death. The most common genetic forms of the disease are associated with desmosomal gene mutations.Aim. To study the prevalence of desmosomal forms of ARVC and to analyze variations in the PKP2, DSG2, DSP, DSC2 and JUP genes in a sample of Russian patients with ARVC.Material and methods. Included patients with ARVC underwent resting electrocardiography (ECG), 24-hour Holter ECG monitoring, echocardiography, chest x-ray, myocardial biopsy (if indicated), contrast-enhanced cardiac magnetic resonance imaging. All patients underwent medical genetic counseling. Mutations in the PKP2, DSG2, DSP, DSC2, and JUP genes was detected using highthroughput sequencing on the IonTorrent platform, followed by Sanger sequencing of uncovered gene regions. The pathogenicity of identified genetic variations was assessed according to modern guidelines.Results. ARVC was established in 80 Russian unrelated patients. More than half of the probands (57%) in the study sample had definite diagnosis of ARVC, while 30% and 13% — borderline and possible ARVC, respectively. A positive family history of heart disease and/or SCD was noted in 30%. Genetic variants of pathogenicity class IV-V were detected in 15 (18,75%) probands in the PKP2, DSG2, DSP genes. The detection of genetic variants of pathogenicity class IV-V was different in the subgroups of patients with varying degrees of diagnosis reliability: 13 probands (28,3%) in the subgroup with definite ARVC and 2 probands (8,3%) in the subgroup with borderline ARVC. No genotype-positive probands were found in the subgroup with possible ARVC. Variations of unknown clinical significance were found in 13 (16,25%) probands.Conclusion. The diagnostic yield of the desmosomal genes PKP2, DSG2, DSP, DSC2, and JUP was 19% with initial diagnosis of ARVC. The detection of mutations was significantly higher in patients with definite ARVC and severe disease manifestations.
Poa mansfieldii (Poaceae), a new species endemic to Steens Mountain, Oregon, U.S.A.
Authors: Wilson Barbara L. , Otting Nick , Brainerd Richard E. 
Published: November 2021

A short, rhizomatous, gynodioecious Poa occurs on alpine slopes below melting snowbanks on Steens Mountain, an isolated, fault-block mountain in southeast Oregon. It was included in P. chambersii, a dioecious species of Oregon’s Cascade Range with cobwebby hairs on at least the lower calluses, although the Steens Mountain form is gynodioecious and its calluses are glabrous. These differences between the Cascadian and Steens Mountain forms were recognized (Soreng 1998, 2007). The Steens Mountain bluegrass is here described as a narrowly endemic species, Poa mansfieldii.
Astragalus pilosior (Fabaceae), a new species from the Sierra Madre Occidental in Chihuahua, Mexico
Authors: Spellenberg Richard W. , Anderson E. Wynn 
Published: November 2021

Astragalus pilosior Spellenb. & E.W. Anderson is described and illustrated as a new species. It is known to occur in the pine forests of southwestern Chihuahua, Mexico, on the western slopes of the Sierra Madre Occidental between approximately 1900 m and 2500 m elevation. The new species is placed in the section Strigulosi. It is compared with the recently described A. spellenbergii from southwestern Durango, Mexico.
Comments on species nomenclature and taxonomy in Clusia section Oedematopus (Clusiaceae)
Authors: Luján Manuel A. , Do Nascimiento Jr. José E. 
Published: November 2021

While Oedematopus divaricatus has already been transferred to Clusia using the available synonym C. myrsinites, here we further explain this synonymy and discuss the similarities of this taxon to related species within Clusia in sect. Oedomatopus.
A floristic survey of the Boulder Mountain Park: with notes on its conservation and management (Boulder, Colorado, U.S.A.)
Authors: Hogan Tim 
Published: November 2021

The City of Boulder Mountain Park sits in the eastern foothills of the northern Front Range of Colorado. Approximately 7000 acres (2800 ha) in extent, the study area is characterized by a foothills and montane vegetation and flora, predominantly of western North American distribution. Situated at the interface of the Great Plains and the Rocky Mountains, the flora of the Mountain Park is distinguished by a wealth of species with eastern woodland affinities, as well as a number of southern Rocky Mountain species endemic to the Front Range. Six hundred and ninety-eight (698) species of vascular plants in 426 genera and 100 families are documented in this survey. Twenty (20) of the plants are listed as Species of Special Concern by the Colorado Natural Heritage Program, with an additional 26 listed as sensitive by the City of Boulder Open Space and Mountain Parks Department (OSMP). Introduced non-native species constitute 21% of the flora (147 species), a figure that exaggerates their ecological role in the Park; less than a dozen introduced species are of serious concern in their impact upon native diversity. The Mountain Park is viewed by many as the crown jewel of the City’s OSMP system, and serves as a model for public land management across other open spaces in urban areas nationwide. These forested foothills, with their prominent relief and associated diversity of habitats, serve as one of the last low-elevation nature refuges along the Colorado Front Range. With the increasing urbanization of the region and the loss of biological diversity worldwide, the wisdom of the Boulder community in protecting this landscape is becoming ever more apparent. This report presents a thoroughly revised checklist of the flora of the Boulder Mountain Parks since the area was last inventoried in 1993.
Gonolobus taylorianus (Apocynaceae: Asclepiadoideae: Gonolobinae) in Florida, U.S.A.
Authors: Krings Alexander , Franck Alan , Hammer Roger , Jestrow Brett , Renfro Rex , Lange James 
Published: November 2021

Gonolobus taylorianus is reported naturalized from Miami-Dade County, Florida. A key and photographs are provided to distinguish the three species of Gonolobus known from the continental United States.
The vascular flora of Choctaw County, Mississippi, U.S.A.
Authors: Philley Kevin D. 
Published: November 2021

The state of Mississippi is one of the least botanically explored areas in the eastern United States. A floristic survey of Choctaw County, Mississippi, was conducted from November 2009 through November 2017 in order to document the vascular flora and describe its plant communities. The county is located in the central portion of the state within the North Central Plateau physiographic region, an area dominated by dissected uplands with acidic to circumneutral sandy-clay soils. Three major river basins occur in the county, including the Big Black River, Noxubee River, and Pearl River. A total of 950 vascular plant species (958 taxa including varieties, subspecies, and recognized hybrids) was recorded. Three-hundred thirteen of these taxa were new county records. Twenty-eight species of special concern as designated by the Mississippi Natural Heritage Program were documented. Approximately 15 percent of the flora is considered non-native to the United States. Eight primary plant communities are also described.
Erratum: Musineon glaucescens (Apiaceae), a new species from central Montana, U.S.A.
Authors: Lesica Peter 
Published: November 2021

The following is a correction for Lesica (2019) J. Bot. Res. Inst. Texas 13(1):1–6. For Page 4, Figure 2 the captions are reversed and should be as follows.Top: M. glaucescens, Lewis & Clark Co., Montana. Bottom: Musineon vaginatum, Missoula Co., Montana.
Effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia
Authors: KAYA Bülent , PAYDAS Saime , KUZU Tolga , DEMİROGLU Omer , YÜCEL KARAKAYA Sevinç Püren , BALAL Mustafa , TAŞOVA Yeşim 
Published: November 2021

Purpose: We investigated the effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia.
Materials and Methods: In this single-center retrospective study, we recorded characteristics of hospitalized covid-19 pneumonia patients and laboratory test results on the first hospital day. Duration of hospitalization, requiring intensive care including mechanical ventilation and survival, were determined.
Results: Our study included 185 patients and of them 111 male (60% male) patients with mean age of 64 ± 14.5 (23-90). Patients were grouped as hypokalemic (16.8%) and normokalemic patients (83.2%). The number of diabetic patients was higher in the normokalemic group. Serum total protein and albumin levels were lower in hypokalemic group, while alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin, direct bilirubin, blood pH and bicarbonate level were higher. In multiple logistic regression analyses, alkalosis increased risk of hypokalemia 5.73 times. Duration of hospitalization, requirement of intensive care and hospital mortality were similar in hypokalemia and normokalemia patients.
Conclusion: In patients with Covid-19 pneumonia, hypokalemia has been found to be quite common as high as 16.8% at the first presentation. Hypokalemia was related to metabolic alkalosis but unrelated to the duration of hospitalization, requirement of intensive care including mechanical ventilation and hospital mortality.
Ferritin and transferrin levels of the elderly population at Lagos State university teaching hospital, Ikeja, Lagos, Nigeria
Authors: Kareem Abdulateef O. , Akinbami Akinsegun A. , Uche Ebele I. , Suleiman Aishatu M. , Bamiro Rafah A. , Augustine Benjamin , Odebiyi Hassan A. , Odunniyi A. O. 
Published: November 2021

<p class="abstract"><strong>Background:</strong> The elderly have limited regenerative abilities thus predisposing them to various diseases. Measuring both serum ferritin and transferrin serve as biomarkers of iron deficiency. This study, using enzyme-linked immunosorbent assay (ELISA) determined the serum levels of ferritin and transferrin in the elderly. Full blood count was also done and correlated with serum ferritin and transferrin levels of every participant.</p><p class="abstract"><strong>Methods:</strong> This was a cross-sectional study at the Geriatric Clinic of Lagos State University Teaching Hospital (LASUTH). Following receipt of written consents from ninety (90) elderly participants, venous samples were drawn for full blood count (FBC) and samples for serum ferritin and transferrin ELISA assay collected and stored at -40<sup>o</sup>C until the required sample size was obtained. Data were analyzed using SPSS version 23.0 (Statistical Package for Social Sciences, Inc., Chicago, Ill). The Pearson chi-square test was used for statistical analysis. P value was considered to be statistically significant when &lt;0.05. </p><p class="abstract"><strong>Results:</strong> Participants consisted of 50 (55.6%) females and 40 (44.4%) males. The mean age of all participants was 71.31±7.38 years. The Majority, 90% (36 of 40) of the males had haemoglobin values lower than 13 gm/dl, while 66% (33 of 50) of females had haemoglobin values lower than 12 gm/dl. The mean ferritin concentration of all participants was 196.19 ±121.21ng/ml. The overall mean serum transferrin was 0.187±0.157 ng/ml with a minimum of 0.03 ng/ml and a maximum of 1.18 ng/ml.</p><p class="abstract"><strong>Conclusions:</strong> Anaemia in the elderly is very common using the World Health Organization (WHO) haemoglobin cut-off values, however, iron deficiency anaemia prevalence is low.</p>
Adverse Local Tissue Reaction and Late-Onset Eosinophilic Gastroenteritis After Primary Total Hip Arthroplasty
Authors: Mihara Masahiko , Hirakawa Kazuo , Takayanagi Satoshi , Maekawa Kazunari , Kitagawa Ryuta , Sato Toshifumi 
Published: November 2021

Case:
A 67-year-old woman suffered from chronic diarrhea at 10 years after right total hip arthroplasty. She also had a pseudotumor caused by an adverse local tissue reaction (ALTR) in her right pelvis. We performed revision arthroplasty, in part because we suspected the diarrhea may have been associated with the intrapelvic pseudotumor. She was later diagnosed with eosinophilic gastroenteritis (EGE).

Conclusion:
Although these two diseases were thought be be related through a similar immune reaction, our patient's clinical course suggests that the ALTR and EGE were independent events.
Climate Change and Variability in the Northeastern Himalayan Region of India
Authors: Saitluanga Benjamin L , Lalchhandama Gabriel , Rinawma P 
Published: November 2021

Mountainous regions are considered highly vulnerable to the affects of climate change. The extent of change and variability of climatic parameters is still unexamined in many remote mountainous areas. This paper aims in understanding the change in pattern of rainfall and temperature for a period of 30 years in Mizoram. The analysis of time series changing trend in climatic variables is carried out by using Coefficient of Variation (CV), Mann-Kendall (M-K) and Sen’s Slope estimator. The analysis reveals that high variation is observed for both the variables in all the decadal, three decadal and seasonal change. The CV analysis shows that the highest seasonal rainfall variation occurs during winter and the highest seasonal temperature variation occurs during spring. Mann-Kendall test shows a significant change in rainfall with November showing the highest negative trend of rainfall. The temperature trend analysis in the study also reveals drastic change of temperature. An understanding of climatic change, trend and variability helps in predicting for better natural resources from the susceptibility of climate change.
Efficient Drilling Sequence Optimization Using Heuristic Priority Functions
Authors: Wang Z. , He J. , Tanaka S. , Wen X.-H. 
Published: November 2021

SummaryDrilling sequence optimization is a common challenge faced in the oil and gas industry, and yet it cannot be solved efficiently by existing optimization methods due to its unique features and constraints. For many fields, the drilling queue is currently designed manually based on engineering heuristics. In this paper, we combined the heuristic priority functions (HPFs) with traditional optimizers to boost the optimization efficiency at a lower computational cost to speed up the decision-making process.The HPFs are constructed to map the individual well properties such as well index and interwell distance to the well priority values. As the name indicates, wells with higher priority values will be drilled earlier in the queue. The HPFs are a comprehensive metric of interwell communication and displacement efficiency. For example, injectors with fast support to producers, or producers with a better chance to drain the unswept region, tend to have high scores. They contain components that weigh the different properties of a well. These components are then optimized during the optimization process to generate the beneficial drilling sequences. Embedded with reservoir engineering heuristics, the priority function (PF) helps the optimizer focus on exploring scenarios with promising outcomes.The proposed HPFs, combined with the genetic algorithm (GA), have been tested through drilling sequence optimization problems for the Brugge Field and Olympus Field. Optimizations that are directly performed on the drilling sequence are used as reference cases. Different continuous/categorical parameterization schemes and various forms of HPFs are also investigated. Our exploration reveals that the HPF including well type, constraints, well index, distance to existing wells, and adjacent oil in place (OIP) yields the best outcome. The proposed approach achieved a better optimization starting point (∼5 to 18% improvement due to more reasonable drilling sequence rather than random guess), a faster convergence rate (results stabilized at 12 vs. 30 iterations), and a lower computational cost [150 to 250 vs. 1,300 runs to achieve the same net present value (NPV)] over the reference methods. Similar performance improvement was also observed in another application to a North Sea–type reservoir. This demonstrated the general applicability of the proposed method.The use of HPFs improves the efficiency and reliability of drilling sequence optimization compared with the traditional methods that directly optimize the sequence. They can be easily embedded in either commercial or research simulators as an independent module. In addition, they are also an automatic process that fits well with iterative optimization algorithms.NOTE: This paper is also published as part of the 2021 SPE Reservoir Simulation Conference Special Issue.
Experimental Investigation of Polyethylene Oxide Polymer Solutions for Enhanced Oil Recovery in Low-Permeability Carbonate Rocks
Authors: Mejía Miguel , Pope Gary A. , Song Haofeng , Balhoff Matthew T. 
Published: November 2021

SummaryNew experiments using polyethylene oxide (PEO) polymer were performed to evaluate its potential for enhanced oil recovery (EOR) applications in low-permeability reservoirs. This is the first time that high molecular weight PEO solutions have been shown to have favorable transport in low-permeability (~20 md) carbonate cores and the first time PEO has been shown to improve oil recovery in a fractured carbonate core. Rheology measurements in synthetic seawater show the higher viscosity of PEO solutions compares favorably to the viscosity of acrylamide–sodium acrylate (AM-AA) copolymers of similar molecular weight because PEO is less sensitive to hardness and high salinity. Filtration experiments using 0.45 μm cellulose filters show very favorable filtration ratios of PEO with a molecular weight of 4 million g/mol, which is consistent with its favorable transport in low-permeability cores. Four coreflood experiments in Texas Cream Limestone (TC Limestone) cores demonstrate the viability of PEO for EOR in low-permeability carbonate rocks. Single-phase experiments show 4 million g/mol PEO solutions transported through 18 and 28 md TC Limestone cores. Oil recovery experiments show 4 million g/mol PEO solutions transported and was more efficient than waterflooding in aged TC Limestone with favorable retention of 40 µg/g rock. An oil recovery experiment in an artificially fractured TC Limestone core improved oil recovery by a remarkable 15% considering the very large fracture-matrix permeability contrast (&gt;7,000). These experimental results as well as other favorable properties of PEO reported in the literature indicate PEO should be considered for some EOR applications, especially in low-permeability reservoirs.