bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE RELATIONSHIP OF BLOOD PRESSURE AND HEART RATE TO VO2MAX IN ADOLESCENT
Authors: NINGRUM TYAS SARI RATNA 
Published: February 2021

ABSTRAK
Pendahuluan : Selama aktivitas fisik yang kita lakukan maka akan terjadi perubahan tekanan darah denyut nadi sebagai respon untuk mengangkut O2 ke otot yang sedang beraktivitas. Adolescent usia 18-21 tahun jaman sekarang memiliki masalah terkait dengan gerak yang mengakibatkan menurunnya ketahanan latihan. Tujuan : menganalisa hubungan antara perubahan tekanan darah dan nadi terhadap VO2Max dan menganalisa seberapa erat hubungannya. Metode : penelitian ini merupakan penelitian observatif dengan Teknik pengambilan sampel purposive sampling dengan desain point time approach sejumlah 183 sampel dengan kriteria usia 18-21 tahun. Variabel independent pada penelitian ini adalah ketahanan latihan, dan variabel dependent adalah perubahan tekanan darah dan perubahan frekuensi nadi. Data diolah menggunakan perangkat lunak untuk Analisa data. Hasil : Dari uji normalitas data menggunakan Kolmogorov Smirnov untuk data tekanan darah dengan nilai 0.509, data nadi dengan nilai 0.069, data VO2Max dengan nilai 0.060. Uji Analisa data menggunakan uji pearson product moment menghasilkan nilai tekanan darah -0.000 dengan nilai r -0.029 dan nilai -0.029. Kesimpulan : terdapat hubungan perubahan tekanan darah dan nadi terhadap VO2Max.
Kata Kunci : Tekanan darah, Nadi, VO2Max

ABSTRACT
Introduction: During the physical activity that we do, there will be a change in pulse blood pressure in response to transporting O2 to the muscles that are on the move. Adolescents 18-21 years of age today have problems related to movement that result in decreased resistance training. Purpose: to analyze the relationship between changes in blood pressure and pulse to VO2Max and to analyze how closely it is. Methods: This study is an observative study using purposive sampling technique with a point time approach design with a total of 183 samples with criteria aged 18-21 years. The independent variable in this study is exercise resistance, and the dependent variable is changes in blood pressure and changes in pulse frequency. The data is processed using software for data analysis. Results: From the data normality test using Kolmogorov Smirnov for blood pressure data with a value of 0.509, pulse data with a value of 0.069, VO2Max data with a value of 0.060. Test Data analysis using the Pearson product moment test resulted in a blood pressure value of -0.000 with a value of r -0.029 and a value of -0.029. Conclusion: there is a relationship between changes in blood pressure and pulse to VO2Max.
Keyword : Blood Pressure, Heart Rate, VO2Max
Місця поховань жертв НКВС в Одесі: огляд преси і документів 1943 року
Authors: Аргатюк Сергій , Сапожников Ігор 
Published: February 2021

Стаття присвячена огляду й аналізу деяких епізодів радянських репресій в Одесі, які мали місце у 1930-ті – на початку 1940-х рр., переважно через призму документів і місцевої преси. Цілий стос беззаперечних фактів про них був розкритий для широкої публіки у 1943 році, а потім у 1990-х – 2000-х роках, шляхом розкопок, перепоховання тіл загиблих і публікації документів, що сформувало у більшості одеситів сталий суспільний погляд на ці явища. Однак в останні роки вони стали піддаватися критиці і ревізії за кордоном, а для одеських вчених і краєзнавців сама тема почала зникати з порядку денного. Тому автори ще раз наводять матеріали стосовно того, що у 1943 р. були досліджені два місця поховань жертв розстрілів НКВС: на міському звалищі біля кургану Могила Татарська, неподалік 6-го км Овідіопольського шосе та на ІІ-му християнському кладовищі. Для повнішого розкриття теми, републікуються дві газетні статті, в яких описані ці місця та виявлені там численні знахідки та факти, які прямо вказували на час, організаторів і виконавців.
Systematic Evaluation of Kinetics and Distribution of Muscle and Lymph Node Activation Measured by 18F-FDG- and 11C-PBR28-PET/CT Imaging, and Whole Blood and Muscle Transcriptomics After Immunization of Healthy Humans With Adjuvanted and Unadjuvanted Vaccines
Authors: Win Zarni , Weiner 3rd January , Listanco Allan , Patel Neva , Sharma Rohini , Greenwood Aldona , Maertzdorf Jeroen , Mollenkopf Hans-Joachim , Pizzoferro Kat , Cole Thomas , Bodinham Caroline L. , Kaufmann Stefan H. E. , Denoel Philippe , Del Giudice Giuseppe , Lewis David J. M. 
Published: February 2021

Systems vaccinology has been applied to detect signatures of human vaccine induced immunity but its ability, together with high definition in vivo clinical imaging is not established to predict vaccine reactogenicity. Within two European Commission funded high impact programs, BIOVACSAFE and ADITEC, we applied high resolution positron emission tomography/computed tomography (PET/CT) scanning using tissue-specific and non-specific radioligands together with transcriptomic analysis of muscle biopsies in a clinical model systematically and prospectively comparing vaccine-induced immune/inflammatory responses. 109 male participants received a single immunization with licensed preparations of either AS04-adjuvanted hepatitis B virus vaccine (AHBVV); MF59C-adjuvanted (ATIV) or unadjuvanted seasonal trivalent influenza vaccine (STIV); or alum-OMV-meningococcal B protein vaccine (4CMenB), followed by a PET/CT scan (n = 54) or an injection site muscle biopsy (n = 45). Characteristic kinetics was observed with a localized intramuscular focus associated with increased tissue glycolysis at the site of immunization detected by 18F-fluorodeoxyglucose (FDG) PET/CT, peaking after 1–3 days and strongest and most prolonged after 4CMenB, which correlated with clinical experience. Draining lymph node activation peaked between days 3–5 and was most prominent after ATIV. Well defined uptake of the immune cell-binding radioligand 11C-PBR28 was observed in muscle lesions and draining lymph nodes. Kinetics of muscle gene expression module upregulation reflected those seen previously in preclinical models with a very early (~6hrs) upregulation of monocyte-, TLR- and cytokine/chemokine-associated modules after AHBVV, in contrast to a response on day 3 after ATIV, which was bracketed by whole blood responses on day 1 as antigen presenting, inflammatory and innate immune cells trafficked to the site of immunization, and on day 5 associated with activated CD4+ T cells. These observations confirm the use of PET/CT, including potentially tissue-, cell-, or cytokine/chemokine-specific radioligands, is a safe and ethical quantitative technique to compare candidate vaccine formulations and could be safely combined with biopsy to guide efficient collection of samples for integrated whole blood and tissue systems vaccinology in small-scale but intensive human clinical models of immunization and to accelerate clinical development and optimisation of vaccine candidates, adjuvants, and formulations.
Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF
Authors: Weiss Emmanuel , de la Grange Pierre , Defaye Mylène , Lozano Juan José , Aguilar Ferrán , Hegde Pushpa , Jolly Ariane , Moga Lucile , Sukriti Sukriti , Agarwal Banwari , Gurm Haqeeqat , Tanguy Marion , Poisson Johanne , Clària Joan , Abback Paer-Selim , Périanin Axel , Mehta Gautam , Jalan Rajiv , Francoz Claire , Rautou Pierre-Emmanuel , Lotersztajn Sophie , Arroyo Vicente , Durand François , Moreau Richard 
Published: February 2021

Background and AimsPatients with cirrhosis and acute-on-chronic liver failure (ACLF) have immunosuppression, indicated by an increase in circulating immune-deficient monocytes. The aim of this study was to investigate simultaneously the major blood-immune cell subsets in these patients.Material and MethodsBlood taken from 67 patients with decompensated cirrhosis (including 35 critically ill with ACLF in the intensive care unit), and 12 healthy subjects, was assigned to either measurements of clinical blood counts and microarray (genomewide) analysis of RNA expression in whole-blood; microarray (genomewide) analysis of RNA expression in blood neutrophils; or assessment of neutrophil antimicrobial functions.ResultsSeveral features were found in patients with ACLF and not in those without ACLF. Indeed, clinical blood count measurements showed that patients with ACLF were characterized by leukocytosis, neutrophilia, and lymphopenia. Using the CIBERSORT method to deconvolute the whole-blood RNA-expression data, revealed that the hallmark of ACLF was the association of neutrophilia with increased proportions of macrophages M0-like monocytes and decreased proportions of memory lymphocytes (of B-cell, CD4 T-cell lineages), CD8 T cells and natural killer cells. Microarray analysis of neutrophil RNA expression revealed that neutrophils from patients with ACLF had a unique phenotype including induction of glycolysis and granule genes, and downregulation of cell-migration and cell-cycle genes. Moreover, neutrophils from these patients had defective production of the antimicrobial superoxide anion.ConclusionsGenomic analysis revealed that, among patients with decompensated cirrhosis, those with ACLF were characterized by dysregulation of blood immune cells, including increases in neutrophils (that had a unique phenotype) and macrophages M0-like monocytes, and depletion of several lymphocyte subsets (including memory lymphocytes). All these lymphocyte alterations, along with defective neutrophil superoxide anion production, may contribute to immunosuppression in ACLF, suggesting targets for future therapies.
Integrated Analysis Reveals ENDOU as a Biomarker in Head and Neck Squamous Cell Carcinoma Progression
Authors: Xu Chengzhi , Zhang Yunbin , Shen Yupeng , Shi Yong , Zhang Ming , Zhou Liang 
Published: February 2021

BackgroundHead and neck squamous cell carcinoma (HNSCC) is a leading cancer with high morbidity and mortality worldwide. The aim is to identify genes with clinical significance by integrated bioinformatics analysis and investigate their function in HNSCC.MethodsWe downloaded and analyzed two gene expression datasets of GSE6631 and GSE107591 to screen differentially expressed genes (DEGs) in HNSCC. Common DEGs were functionally analyzed by Gene ontology and KEGG pathway enrichment analysis. Protein-protein interaction (PPI) network was constructed with STRING database and Cytoscape. ENDOU was overexpressed in FaDu and Cal-27 cell lines, and cell proliferation and migration capability were evaluated with MTT, scratch and transwell assay. The prognostic performance of ENDOU and expression correlation with tumor infiltrates in HNSCC were validated with TCGA HNSCC datasets.ResultsNinety-eight genes shared common differential expression in both datasets, with core functions like extracellular matrix organization significantly enriched. 15 genes showed prognostic significance, and COBL and ENDOU serve as independent survival markers in HNSCC. In-vitro ENDOU overexpression inhibited FaDu and Cal-27 cells proliferation and migration, indicating its tumor-suppressing role in HNSCC progression. GSEA analysis indicated ENDOU down-stream pathways like DNA replication, mismatch repair, cell cycle and IL-17 signaling pathway. ENDOU showed relative lower expression in HNSCC, especially HPV-positive HNSCC samples. At last, ENDOU showed negative correlation with tumor purity and tumor infiltrating macrophages, especially M2 macrophages.ConclusionThis study identified ENDOU as a biomarker with prognostic significance in HNSCC progression.
Students motivation for admission to study on the educational program "Physical Education and Recreation"
Authors: Sitepu Akor , Cahyadi Ardian , Tarigan Herman 
Published: February 2021

Aim: to determine how the motivations and backgrounds of students in Physical Education and recreation in the Physical Education and Recreation Study Program. Material and methods. The method used in this research is a survey method with data collection techniques by distributing questionnaires to all students who are studying in the Lampung University Recreational Physical Education Study Program. The instrument used in this study was a questionnaire consisting of questions about student motivation to enter Lampung University Physical Education Study and additional questions about student backgrounds, school origins and data about students' parents. The shape of the instrument is in the form of multiple choice with a variety of choices, this gives the opportunity for students to choose according to the actual situation. The research sample was determined by census, namely all undergraduate students of Physical Education and Research, Lampung University consisting of 66 undergraduate students who were currently actively attending lectures. Results. From the results of the study, it can be seen that the motivation to enter FKIP in the Penjaskesrek study program, Lampung University was more through the Academic PMDK compared to admissions through SPMB and PMDK Achievement and Talent. Of these, some students who enter the Physical Education study program are motivated because they want to become teachers, join ABRI or train. From this situation it is hoped that their interest will grow in fostering sports that are of interest and from them it is hoped that success in increasing sports achievements both at the regional and national levels. The number of students admitted to the Physical Education and Recreation study program amounted to 72 people, but only 66 students returned the questionnaire, which means more than 50% so that this research can be said to have represented the Physical Education and Recreation students. Conclusions. Received, that of the 66 students of the Physical Education and Recreation study program, 27 people or 40% were accepted through SNMPTN, 23 people or 34.84% were accepted through the SBMPTN, 14 students or 21.21% were accepted through Mandiri and 2 people or 3.03% were accepted via PMPAT.
desafíos de la Nueva Ruta de la seda para América Latina:
Authors: Bravo Lucía 
Published: February 2021

La complejidad que implica el tablero de las relaciones internacionales ha experimentado importantes cambios en este último siglo. La iniciativa impulsada por China desde el 2013 conocida como “Iniciativa de la Franja y la Ruta” (IFR), o como el “proyecto del siglo” tiene el potencial de cambiar la geografía económica y estratégica del mundo, re orientándola hacia el pacífico, con centro en Oriente.
En el caso de América Latina se refleja en una fuerte cantidad de inversiones en infraestructura, orientando el comercio hacia una reprimarización de las economías regionales. Después de siete años del lanzamiento oficial de este proyecto se abre el interrogante sobre si las nuevas estructuras y entidades financieras creadas por China se orientarán a profundizar el denominado consenso de Beijing, y sobre cuáles son los riesgos y desafíos de la nueva Ruta de la Seda para América Latina.
El presente trabajo tiene como finalidad analizar geopolíticamente, desde una perspectiva latinoamericana, cuales son las implicancias de la Nueva Ruta de la Seda para la región, planteando el desafío que implica insertarse dentro del plan chino, las oportunidades que genera en términos de desarrollo y cuales son los márgenes de autonomía. Para esto a los fines metodológicos, el trabajo está centrado en tres aspectos: a) los lineamientos generales y estratégicos de la Nueva Ruta de la Seda; b) el significado y alcance para la región; y c) y el desafío entre las oportunidades y la autonomía que se plantea la región ante el BRI.
PENGGUNAAN VIDEO EDUKASI DALAM UPAYA PENANGGULANGAN PENYAKIT KULIT PADA PEMULUNG
Authors: Valentina Valentina , Erlindai Erlindai 
Published: February 2021

Penyakit kulit merupakan salah satu masalah kesehatan yang sering diderita oleh pemulung di Tempat Pembuangan Akhir Sampah Terjun Kota Medan, dengan proporsi 70,7% pada tahun 2018. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian informasi kesehatan menggunakan video edukasi dalam upaya penanggulangan penyakit kulit pada pemulung. Penelitian ini menggunakan quasi eksperimen dengan non equivalent control group design. Sampel kelompok intervensi diambil secara purposive sejumlah 30 orang pemulung di Tempat Pembuangan Akhir Terjun. Sedangkan kelompok kontrol berjumlah 30 orang yang merupakan kelompok pemulung yang tinggal di Tempat Pembuangan Akhir Namo Bintang. Pengumpulan data menggunakan menggunakan kuesioner. Analisis data menggunakan uji Wilcoxon dan Mann Whitney dengan Confidence Interval 95% untuk mengukur perubahan pengetahuan dan sikap pada kelompok intervensi. Penelitian menunjukan ada peningkatan nilai rata-rata pengetahuan yaitu dari 10,86 menjadi 12,80 dan nilai rata-rata sikap meningkat dari 52,96 menjadi 59,76 . Hasil penelitian menunjukkan ada pengaruh pemberian informasi kesehatan menggunakan video edukasi terhadap peningkatan pengetahuan (p value = 0,001) dan sikap (p value = 0,0001) dalam upaya penanggulangan penyakit kulit pada pemulung di Tempat Pembuangan Akhir Terjun Kota Medan. Disarankan kepada Puskesmas Terjun untuk memberikan informasi kesehatan kepada pemulung mengenai sanitasi lingkungan rumah dan kebersihan diri dalam upaya penanggulangan penyakit kulit menggunakan video edukasi secara berkelanjutan.
PERILAKU MASYARAKAT INDONESIA BAGIAN BARAT SELAMA PANDEMI COVID 19
Authors: Sitohang Tiur Romatua , Rosyad Yafi Sabila , Rias Yohanes Andy , Malini Hema , Widodo Aji Kiyat 
Published: February 2021

Latar Belakang: Organisasi Kesehatan Dunia (WHO) menyatakan bahwa Penyakit Coronavirus 2019 dikategorikan sebagai pandemi global.Hingga tanggal 31 Maret 2020, jumlah positif Covid -19 di Indonesia sebanyak 1.528 kasus, pasien sembuh 81 orang , meninggal dunia sebanyak 136 orang. Tindakan penanggulangan COVID-19 masih tetap berlanjut sampai saat ini, dibutuhkan kepatuhan masyarakat terhadap langkah-langkah upaya yang dilakukan, yang sebagian besar dipengaruhi oleh pengetahuan, sikap, dan tindakan masyarakat terhadap COVID-19.Tujuan : Mengetahui gambaran distribusi frekuensi pengetahuan, sikap dan tindakan masyarakat Indonesia Bagian Barat selama Pandemi Covid 19.Metode : Metode kuantitatif dengan jumlah sampel adalah masyarakat Indonesia Bagian Barat sebanyak 817 orang. Teknik pengambilan sampel menggunakan random sampling.Hasil: Hasil analisa data univariat diperoleh sebagian besar pengetahuan masyarakat Indonesia Bagian Barat selama pandemi Covid 19 adalah berpengetahuan baik yaitu sejumlah 581 orang (71,1%), sebagian besar sikap masyarakat Indonesia Bagian Barat Selama Pandemic Copid 19 adalah sikap positif yaitu sejumlah 761 orang (93,1%), sebagian besar tindakan masyarakat Indonesia Bagian Barat Selama Pandemic Covid 19 adalah tindakan positif yaitu sejumlah 607 orang (74,3%).Kesimpulan : Sebagian besar masyarakat Indonesia Bagian Barat memiliki pengetahuan yang baik, sikap yang positif dan tindakan yang positif sebagai upaya untuk mencegah penularan COVID-19
Overcoming optimization constraint for J
c by hybrid pinning in YBa2Cu3O7 films containing nanorods
Authors: Horide Tomoya , Torigoe Kenta , Kita Ryusuke , Awaji Satoshi , Matsumoto Kaname 
Published: February 2021

Abstract
Critical current density (J
c) in YBa2Cu3O7 films are improved by nanorods. J
c increases with increasing the nanorod content up to an optimum content, and decreases after exhibiting a maximum due to degradation of the nanorod structure. To overcome this optimization constraint, hybrid pinning consisting of multiple types of pinning centers was investigated. In the present study, Y2O3 nanoparticles were additionally introduced into the YBa2Cu3O7 films containing high density BaHfO3 nanorods to increase the effective matching field. As a result, the global pinning force maximum was shifted to high magnetic field, and the J
c was improved especially in high magnetic field. Thus, even in the case that the J
c improvement in the YBa2Cu3O7 + BaHfO3 was difficult by increasing the nanorod content, the Y2O3 addition successfully improved the J
c. This demonstrates that the hybrid pinning can overcome the optimization constraint for J
c in the YBa2Cu3O7 films containing nanorods.
Interpretation of the European Convention for the Protection of Human Rights and Fundamental Freedoms in the light of modern concepts of legal understanding
Authors: Liashenko Ruslana , Dobrovinsky Myroslav 
Published: February 2021

The article presents the results of theoretical and practical research of the interpretation of the European Convention for the Protectionof Human Rights and Fundamental Freedoms in the light of modern concepts of legal understanding.On July 17, 1997, Verkhovna Rada of Ukraine ratified the European Convention for the Protection of Human Rights and FundamentalFreedoms of 1950 (hereinafter – the Convention), which was the initial stage in the formation and development of Ukrainianlaw and legal science in general. From that moment, a new stage began – the introduction of legal practice and legal values of Europeinto Ukrainian law.The Convention for the Protection of Human Rights and Fundamental Freedoms, as a complex mechanism has a direct effectwithin the jurisdiction of the Ukrainian court system, the principles of interpretation of the Convention applied by the European Courtof Human Rights are valuable and special for judges in Ukraine. One of the main methods of interpreting the Convention is the principleof judicial precedent. Judicial case law is an important part of the legal system of common law states, and the increase in the boundariesof judicial precedent has been observed in Western Europe over the past century. The case law of the European Court of Human Rightsis an additional factor for the official recognition of judicial precedent as a source of law in the protection of human rights, which willhelp strengthen the independence of the judiciary in Ukraine.
Nowadays, the use of the Convention for the Protection of Human Rights and Fundamental Freedoms in Ukraine makes it possibleto replace the prevailing positivist views on law, apply the latest principles of interpretation of human and civil rights, and developthe constitutional jurisprudence of fundamental human rights.The Convention opens a new horizon of tasks in the development of democracy in Ukraine, with the basic principles of whichvarious legal acts of the country must be monitored for compliance with fundamental human rights and freedoms.Through the interpretation and use of the Convention, our state has begun a rapid process of moving away from the positivistunderstanding of law, which has resulted in the emergence of the necessary for the further development of pluralism of legal understandingof law.