bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right versus left ventricular remodeling in heart failure due to chronic volume overload
Authors: Havlenova Tereza , Skaroupkova Petra , Miklovic Matus , Behounek Matej , Chmel Martin , Jarkovska Dagmar , Sviglerova Jitka , Stengl Milan , Kolar Michal , Novotny Jiri , Benes Jan , Cervenka Ludek , Petrak Jiri , Melenovsky Vojtech 
Published: August 2021

AbstractMechanisms of right ventricular (RV) dysfunction in heart failure (HF) are poorly understood. RV response to volume overload (VO), a common contributing factor to HF, is rarely studied. The goal was to identify interventricular differences in response to chronic VO. Rats underwent aorto-caval fistula (ACF)/sham operation to induce VO. After 24 weeks, RV and left ventricular (LV) functions, gene expression and proteomics were studied. ACF led to biventricular dilatation, systolic dysfunction and hypertrophy affecting relatively more RV. Increased RV afterload contributed to larger RV stroke work increment compared to LV. Both ACF ventricles displayed upregulation of genes of myocardial stress and metabolism. Most proteins reacted to VO in a similar direction in both ventricles, yet the expression changes were more pronounced in RV (pslope: < 0.001). The most upregulated were extracellular matrix (POSTN, NRAP, TGM2, CKAP4), cell adhesion (NCAM, NRAP, XIRP2) and cytoskeletal proteins (FHL1, CSRP3) and enzymes of carbohydrate (PKM) or norepinephrine (MAOA) metabolism. Downregulated were MYH6 and FAO enzymes. Therefore, when exposed to identical VO, both ventricles display similar upregulation of stress and metabolic markers. Relatively larger response of ACF RV compared to the LV may be caused by concomitant pulmonary hypertension. No evidence supports RV chamber-specific regulation of protein expression in response to VO.
CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
Authors: Ren Yan-Long , Li Tao-Tao , Cui Wei , Zhao Li-Min , Gao Na , Liao Hua , Zhang Jiang-Hui , Zhu Jun-Ming , Qiao Zhi-Yu , Guo Shi-Chao , Pan Li-Li 
Published: August 2021

AbstractInterferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls were enrolled. The lymphocyte subsets of peripheral blood were detected by flow cytometry, cytokines were detected by Bio-plex. The correlation among lymphocyte subsets, cytokines and disease activity indexes was analyzed by person correlation. The level of serum IFN-γ in TAK patients was significantly increased (P < 0.05). The percentage of CD3+IFN-γ+ cells in peripheral blood CD3+ cells was significantly higher in TAK patients than that of healthy control group (P = 0.002). A higher proportion of CD3+CD8+IFN-γ+ cells/CD3+IFN-γ+ cells (40.23 ± 11.98% vs 35.12 ± 11.51%, P = 0.049), and a significantly lower CD3+CD4+IFN-γ+/ CD3+CD8+IFN-γ+ ratio (1.34 ± 0.62% vs 1.80 ± 1.33%, P = 0.027) were showed in the TAK group than that of control group. The CD3+CD8+IFN-γ+/CD3+IFN-γ+ ratio was positively correlated with CD3+IFN-γ+cells/ CD3+cells ratio (r = 0.430, P = 0.001), serum IFN-γ level (r = 0.318, P = 0.040) and IL-17 level (r = 0.326, P = 0.031). It was negatively correlated with CD3+CD4+IFN-γ+/CD3+IFN-γ+ ratio (r = − 0.845, P < 0.001). IFN-γ secreted by CD3+CD8 + T cells is an important source of serum IFN-γ in TAK patients.
Dual-pulse photoactivated atomic force microscopy
Authors: Park Byullee , Lee Seunghyun , Kwon Jimin , Kim Woojo , Jung Sungjune , Kim Chulhong 
Published: August 2021

AbstractPhotoactivated atomic force microscopy (pAFM), which integrates light excitation and mechanical detection of the deflections of a cantilever tip, has become a widely used tool for probing nanoscale structures. Raising the illuminating laser power is an obvious way to boost the signal-to-noise ratio of pAFM, but strong laser power can damage both the sample and cantilever tip. Here, we demonstrate a dual-pulse pAFM (DP-pAFM) that avoids this problem by using two laser pulses with a time delay. The first laser heats the light absorber and alters the local Grüneisen parameter value, and the second laser boosts the mechanical vibration within the thermal relaxation time. Using this technique, we successfully mapped the optical structures of small-molecule semiconductor films. Of particular interest, DP-pAFM clearly visualized nanoscale cracks in organic semiconductor films, which create crucial problems for small-molecule semiconductors. DP-pAFM opens a promising new optical avenue for studying complex nanoscale phenomena in various research fields.
Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
Authors: Petreus Tudor , Cadogan Elaine , Hughes Gareth , Smith Aaron , Pilla Reddy Venkatesh , Lau Alan , O’Connor Mark James , Critchlow Susan , Ashford Marianne , Oplustil O’Connor Lenka 
Published: August 2021

AbstractMicrophysiological in vitro systems are platforms for preclinical evaluation of drug effects and significant advances have been made in recent years. However, existing microfluidic devices are not yet able to deliver compounds to cell models in a way that reproduces the real physiological drug exposure. Here, we introduce a novel tumour-on-chip microfluidic system that mimics the pharmacokinetic profile of compounds on 3D tumour spheroids to evaluate their response to the treatments. We used this platform to test the response of SW620 colorectal cancer spheroids to irinotecan (SN38) alone and in combination with the ATM inhibitor AZD0156, using concentrations mimicking mouse plasma exposure profiles of both agents. We explored spheroid volume and viability as a measure of cancer cells response and changes in mechanistically relevant pharmacodynamic biomarkers (γH2AX, cleaved-caspase 3 and Ki67). We demonstrate here that our microfluidic tumour-on-chip platform can successfully predict the efficacy from in vivo studies and therefore represents an innovative tool to guide drug dose and schedules for optimal efficacy and pharmacodynamic assessment, while reducing the need for animal studies.
Long-term stable compressive elastocaloric cooling system with latent heat transfer
Authors: Bachmann Nora , Fitger Andreas , Maier Lena Maria , Mahlke Andreas , Schäfer-Welsen Olaf , Koch Thomas , Bartholomé Kilian 
Published: August 2021

AbstractElastocaloric cooling systems can evolve into an environmentally friendly alternative to compressor-based cooling systems. One of the main factors preventing its application is a poor long-term stability of the elastocaloric material. This especially applies to systems that work with tensile loads and which benefit from the large surface area for heat transfer. Exerting compressive instead of tensile loads on the material increases long-term stability—though at the expense of cooling power density. Here, we present a heat transfer concept for elastocaloric systems where heat is transferred by evaporation and condensation of a fluid. Enhanced heat transfer rates allow us to choose the sample geometry more freely and thereby realize a compression-based system showing unprecedented long-term stability of 107 cycles and cooling power density of 6270 W kg−1.
A novel video noise reduction method based on PDE, adaptive grouping, and thresholding techniques
Authors: Yahya Ali Abdullah , Tan Jieqing , Hu Min 
Published: August 2021

AbstractUndoubtedly, video block‐matching and 3D filtering (VBM3D) has achieved a significant improvement in video denoising. Nevertheless, in practice, failure to distinguish between the different noise areas, ignoring noise variances and pixel intensity, false‐similar patches, and poor matching are the challenges faced by the VBM3D filter. To avoid these drawbacks, a new video denoising algorithm is proposed. This algorithm based on the nature of the noise areas and the spatial distance between the reference block and its candidate blocks. In the algorithm, hard‐thresholding in VBM3D is replaced by adaptive filtering. In this adaptive filter, soft‐thresholding is applied to the heavily contaminated areas, whereas anisotropic diffusion filter is applied to the slight‐noise areas. Applying adaptive filtering creates a balance between noise removal and edges conservation. To avert the occurrence of the poor choice of the threshold, noise variances, clean image coefficients, and pixel intensity are taken into consideration during computing the proposed adaptive threshold. Due to the strong possibility of similar correlative blocks happening in the vicinity, an adaptive grouping technique is proposed to compute the distance between a reference block and its candidate blocks. Applying this technique helps to reduce the occurrence of false‐similar blocks and poor matching.
An XMM–Newton catalogue of BL Lacs
Authors: de la Calle Pérez I. , Álvarez Crespo N. , Racero E. , Rouco A. 
Published: August 2021

Aims. We present an XMM–Newton catalogue of BL Lac X-ray, optical, and UV properties based on cross-correlation with the 1151 BL Lacs listed in the fifth edition of the Roma–BZCAT.
Methods. We searched for the X-ray counterparts to these objects in the field of view of all pointed observations in the XMM–Newton archive over nearly 20 years of mission. The cross-correlation yields a total of 310 XMM–Newton fields which correspond to 103 different BL Lacs. We homogeneously analysed data from the three EPIC cameras (X-ray) and OM (optical/UV) using the XMM–Newton SAS software, and produced images, light curves, and spectral products for BL Lacs detected in any of the three EPIC cameras. We tested two different phenomenological models, log parabola and power law, with different variations of the absorbing column density and extracted their parameters. We derived time-variability information from the light curves following well-established statistical methods and quantified variability through statistical indicators. OM magnitudes and fluxes were computed wherever possible.
Results. We see that the log parabola model is preferred over the power law model for sources showing higher fluxes, which might indicate that curvature is intrinsic to BL Lacs and is only seen when the flux is high. We present the results of our analysis as a catalogue of X-ray spectral properties of the sample in the 0.2–10 keV energy band as well as in the optical/UV band. We complete the catalogue with multi-wavelength information at radio and γ-ray energies.
Spatially resolved X-ray spectra of the galactic SNR G18.95-1.1: SRG/eROSITA view
Authors: Bykov A. M. , Uvarov Y. A. , Churazov E. M. , Gilfanov M. R. , Medvedev P. S. 
Published: August 2021

Aims. We study the X-ray emission of the galactic supernova remnant (SNR) G18.95-1.1 with the eROSITA telescope on board the Spectrum Röntgen Gamma (SRG) orbital observatory. In addition to the pulsar wind nebula that was previously identified and examined by ASCA and Chandra, we study the X-ray spectra of the bright SNR ridge, which is resolved into a few bright clumps.
Methods. The wide field of view and the large collecting area in the 0.2-2.3 keV energy range of SRG/eROSITA allowed us to perform spatially resolved spectroscopy of G18.95-1.1.
Results. The X-ray ridge of G18.95-1.1 is asymmetric, indicating either supernova ejecta asymmetry or their interaction with a cloud. The X-ray dim northern regions outside the pulsar wind nebula can be described by a thin thermal plasma emission with a temperature ~0.3keV and a solar composition. The X-ray spectra of a few bright clumps located along the southern ridge may be satisfactorily approximated by a single thermal component of the Si-rich ejecta at the collisional ionization equilibrium with a temperature of about 0.3 keV. The bright ridge can be alternatively fit with a single component that is not dominated by equilibrium ejecta with T ~ 0.6 keV. The high ratio of the derived Si/O abundances indicates that the ejecta originated in deep layers of the progenitor star. The plasma composition of a southern Si-rich clump and the bright ridge are similar to what was earlier found in the Vela shrapnel A and G.
The operational and research DTM-2020 thermosphere models
Authors: Bruinsma Sean , Boniface Claude 
Published: August 2021

Aims: The semi-empirical Drag Temperature Models (DTM) predict the Earth’s thermosphere’s temperature, density, and composition, especially for orbit computation purposes. Two new models were developed in the framework of the H2020 Space Weather Atmosphere Models and Indices (SWAMI) project. The operational model is driven by the trusted and established F10.7 andKpindices for solar and geomagnetic activity. The so-called research model is more accurate, but it uses the indices F30 and the hourly Hpo, which are not yet accredited operationally.Methods: The DTM2020 models’ backbone comprises GOCE, CHAMP, and Swarm A densities, processed by TU Delft, and Stella processed in-house. They constitute the standards for absolute densities, and they are 20–30% smaller than the datasets used in the fit of DTM2013. Also, the global daily mean TLE densities at 250 km, spanning four solar cycles, were now used to improve solar cycle variations. The operational model employs the same algorithm as DTM2013, which was obtained through fitting all data in our database from 1967 to 2019. Because of the Hpo index, which is not available before 1995, the coefficients linked to the geomagnetic activity of the research model are fitted to data from 2000 to 2019. The algorithm was updated to take advantage of the higher cadence of Hpo. Both models are assessed with independent data and compared with the COSPAR International Reference Atmosphere models NRLMSISE-00, JB2008, and DTM2013. The bias and precision of the models are assessed through comparison with observations according to published metrics on several time scales. Secondly, binning of the density ratios are used to detect specific model errors.Results: The DTM2020 densities are on average 20–30% smaller than those of DTM2013, NRLMSISE-00, and JB2008. The assessment shows that the research DTM2020 is the least biased and most precise model compared to assimilated data. It is a significant improvement over DTM2013 under all conditions and at all altitudes. This is confirmed by the comparison with independent SET HASDM density data. The operational DTM2020 is always less accurate than the research model except at 800 km altitude. It has comparable or slightly higher precision than DTM2013, despite using F10.7 instead of F30 as solar activity driver. DTM, and semi-empirical models in general, can still be significantly improved on the condition of setting up a more complete and consistent total density, composition, and temperature database than available at this time by means of a well-conceived observing system.
Therapieoptionen und outcome bei idiopathischen entzündlichen Muskelerkrankungen
Authors: Unger Leonore 
Published: August 2021

ZusammenfassungDie idiopathischen entzündlichen Muskelerkrankungen (IIM) sind eine sehr heterogene Gruppe, die sich immer besser differenzieren lässt. Damit eröffnen sich mehr Möglichkeiten für gezieltere Therapien, die zum einen auf die Veränderung pathogenetischer Faktoren gerichtet sind. Zum anderen sollen sie Krankheitsaktivität vermindern, Muskelaufbau fördern, Organschäden verhindern und Lebensqualität verbessern.Die folgende Übersichtsarbeit fasst die vorhandenen Daten zu bereits angewandten Behandlungen in der Praxis zusammen und gibt einen Ausblick auf zukünftige Alternativen.Für die Polymyositis (PM) und Dermatomyositis (DM) sind Glukokortikoide weiter unverzichtbarer Therapiebestandteil. Eine frühe Kombination mit konventionellen DMARDs hat sich durchgesetzt. Die ProDerm- Studie stellt für die Immunglobulintherapie in der Praxis eine gute Basis dar. Rituximab (RTX) löst Cyclophosphamid (CYC) bei schweren Verlaufsformen immer mehr ab.Für Abatacept, Jak-Kinase-Hemmer, Apremilast, Sifalimumab und Lenabasum müssen vielversprechende erste Ergebnisse durch weiter Studien untermauert werden. Anspruchsvoll ist die Behandlung bei extramuskulärer Beteiligung. Von großem Interesse ist der zukünftige Stellenwert von Nintedanib bei der interstitiellen Lungenerkrankung im Rahmen einer Myositis (IIM-ILD).Die Therapie der Einschlusskörperchen- Myositis (IBM) ist immer noch eine große Herausforderung. Zahlreiche Studien haben bisher nicht überzeugend zu einer Besserung der Prognose führen können. Spätestens bei therapierefraktärem Verlauf sollte an eine Malignom- assoziierte Myositis gedacht werden. Gelegentlich verbirgt sich auch eine hereditäre Myopathie hinter einer, zum Beispiel durch einen Infekt oder Überlastung getriggerten, Myositis.Komplikationen im Verlauf, wie Dysphagie, Infektionen, Myokardbeteiligung stellen keine Seltenheit dar. Häufig besteht Multimorbidität. Eine interdisziplinäre Zusammenarbeit in einem kompetenten Team, in dem erfahrene Physio-, Ergo- und Psychotherapeuten fester Bestandteil sind, ist unabdingbar für eine erfolgreiche Begleitung dieser Patienten.
Long-term outcome after EUS-guided radiofrequency ablation: Prospective results in pancreatic neuroendocrine tumors and pancreatic cystic neoplasms
Authors: Barthet Marc , Giovannini Marc , Gasmi Mohamed , Lesavre Nathalie , Boustière Christian , Napoleon Bertrand , LaQuiere Arthur , Koch Stephane , Vanbiervliet Geoffroy , Gonzalez Jean-Michel 
Published: August 2021

Abstract
Background and study aims Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for pancreatic neuroendocrine tumors (NETs) and intraductal pancreatic mucinous neoplasia (IPMN) with worrisome features or high-risk stigmata (WF/HRS) has been evaluated in few series with short-term outcomes. This studyʼs primary endpoint was to assess the long-term efficacy of EUS-RFA in patients with NETs or pancreatic cystic neoplasms (PCNs) over at least 3 years.
Patients and methods Twelve patients had 14 NETs with a mean 13.4-mm size (10–20) and 17 patients had a cystic tumor (16 IPMN, 1 MCA) with a 29.1-mm mean size (9–60 were included. They were treated with EUS-guided RFA, evaluated prospectively at 1 year, and followed annually for at least 3 years.
Results The mean duration of follow-up was 42.9 months (36–53). Four patients died during follow-up (17–42 months) from unrelated diseases.At 1-year follow-up, and 85.7 % complete disappearance was seen in 12 patients with 14 NETs. At the end of follow-up (45.6 months), complete disappearance of tumors was seen in 85.7 % of cases. One case of late liver metastasis occurred in a patient with initial failure of EUS-RFA. At 1-year follow-up, a significant response was seen in 70.5 % of 15 patients with PCNs. At the end of the follow-up, there was a significant response in 66.6 % with no mural nodules. Two cases of distant pancreatic adenocarcinoma unrelated to IPMN occurred.
Conclusions EUS-RFA results for pancreatic NETs or PCNs appear to be stable during 42 months of follow-up.
Feasibility of an EUS e-training course with live cases
Authors: Dhir Vinay , Udawat Priyanka , Shah Rahul , Alahari Aruna 
Published: August 2021

Abstract
Background and study aims One-on-one endoscopic ultrasound (EUS) mentorship was not possible at most institutions during the COVID-19 pandemic. We decided to test the feasibility of structured training in EUS with virtual e-classes with live cases. The aim of this study was to assess the feasibility of a virtual EUS training course with objective end points.
Patients and methods Twenty-one trainees were trained on a virtual platform over 16 classes of 90 minutes each, over 3 months. The virtual training screen had two equal parts, one showing the endoscopist’s hand movements, and another the resultant EUS display. The course curriculum included EUS anatomy of the mediastinum, pancreatico-biliary region and rectum. The assessment was done on videos of procedures performed by trainees.
Results Twenty trainees performed 251 EUS procedures (range 8–25, mean 12.5 ± 4.9) at their institutions. At the end of the course, all students (100 %) could maneuver the echo-endoscope through to the duodenum. Fifteen trainees sent a video for final assessment. The successful specified area identification rates were 12 of 15 (80 %) for the subcarinal space, 10 of15 (66.6 %) for the head of the pancreas, 10 of 15 (66.6 %) for the common bile duct, and nine of 15 (60 %) for the tail of pancreas. The success rate of ability to get appropriate windows was 10 of 15 (67 %) for the subcarinal space, eight of 15 (53.3 %) for the head of the pancreas, seven of 15 (46.6 %) for the common bile duct and six of 15 (40 %) for the tail of pancreas. No adverse events were reported.
Conclusions A virtual EUS training course with live cases appears feasible. It allows the possibility of training a large number of students. Further evaluation is needed, especially of virtual assessment methods and training benchmarks.
Video clips compared with high-definition still images for characterization of colorectal neoplastic lesions: a randomized comparative prospective study
Authors: Pioche Mathieu , Jacques Jérémie , Héroin Lucile , Rivory Jérôme , Ponchon Thierry , Legros Romain , Albouys Jérémie , Chaussade Stanislas , Gronier Olivier , Reimund Jean-Marie , Fabacher Thibaut , Sautereau Denis , Dumeirain Franck ,   and the French Society of Digestive Endoscopy (SFED)
Published: August 2021

Abstract
Background and study aims Accurate real-time characterization of colorectal neoplastic lesions (CNLs) during colonoscopy is important for deciding appropriate treatment. No studies have evaluated whether still images or video clips are better for characterization. We compared histological predictions and size estimations of CNLs between two groups of gastroenterologists: one viewing still images and the other viewing video clips.
Materials and methods Participants were shown 20 CNLs as either 3–5 still images or a video clip. Three endoscopy experts obtained the images using high-definition white light and virtual chromoendoscopy without magnification. Stratified randomization was performed according to experience. For each lesion, participants assessed the size and histological subtype according to the CONECCT classification (hyperplastic polyp [IH], sessile serrated lesion [IS], adenoma [IIA], high-risk adenoma or superficial adenocarcinoma [IIC], or deeply invasive adenocarcinoma [III]). The correct histological status and size were defined by the pathology reports or combined criteria between histology and expert opinion for high-risk adenoma or superficial adenocarcinoma (CONECCT IIC).
Results 332 participants were randomized and 233 performed the characterization. Participants comprised 118 residents, 75 gastroenterologists, and 40 endoscopy experts; 47.6 % were shown still images and 52.4 % viewed video clips. There was no statistically significant difference between the two groups in histological prediction, our primary end point. However, the lesion size was better assessed using still images than video clips (P = 0.03).
Conclusions Video clips did not improve the histological prediction of CNLs compared with still images. Size was better assessed using still images.