bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectroscopic Properties and Dispersion Parameters of B2O3 – SiO2 – Bi2O3 – TiO2 – Y2O3 Glasses
Authors: shaaban Kh. S. 
Published: March 2021

Abstract
Glasses with the chemical formula 52B2O3 – 12SiO2- 26Bi2O3 – (10-x) TiO2 - Y2O3, :(0≤ x ≥ 10), the melt-quench method was used to prepare this glass system. The purpose of this article is to investigate the spectroscopic features of these glasses. The nature of the glass system has been investigated using X-ray diffraction analysis. In the current article, the molar volume acquired decreased while the density and refractive index increased. In the current article, Y2O3 plays an important role and impacts the spectroscopic characteristics of the samples accordingly. For all the present glasses, the optical bandgap is found to be in the semiconducting range. The optical bandgap enhances as Y2O3 rises, while Urbach energy reduces. Molar Refractivity, molar polarization, polarization, and optical basicity decrease with increasing Y2O3 content. Wemple and Didomenico principles were used for calculated the Eo and Ed dispersion. The significance of the Y2O3 modifier in the glass system signifies proved.
Bilateral Giant Axillary Artery Aneurysms with Left Complete Embolism in Intravenous Immunoglobulin-Sensitive Kawasaki Disease: A Case Report
Authors: Chu Chen , He Lan , Lin Yi-xiang , Liu Fang 
Published: March 2021

Abstract
Background: Kawasaki disease (KD) is a systemic vasculitis that predominantly affects medium-sized arteries. In addition to well-known coronary artery aneurysms (CAAs), peripheral systemic artery aneurysms (SAAs) have also been sporadically reported. In the literatures, SAAs occurred mainly in untreated, intravenous immunoglobin (IVIG)-resistant, or severe refractory KD, and thrombotic events in SAA were rarely reported.Case presentation: A 10-month-old boy with history of KD was referred to our hospital for suspected pseudoaneurysm of the axillary arteries. Four months prior to presentation, he had recurrent fever, conjunctival congestion, and rash. On the 10th day of fever echocardiography showed biliteral CAAs. He was then diagnosed with KD and given IVIG 2g/kg and aspirin at a local hospital. His fever and symptoms soon subsided and he was discharged with low dose aspirin and dipyridamole. One month prior to presentation, his parents incidentally palpated swellings in his axillae bilaterally. On admission, physical examination revealed a pulsatile swelling in his right axilla and a non-pulsatile swelling in the left. His left brachial and radial pulses were not palpable, while the pulses of other three limbs were normal. His left upper limb was cooler and less active compared to the right. Ultrasound examination revealed bilateral giant axillary artery aneurysms (AAAs) with massive thrombus in the left. Angiography confirmed bilateral giant AAAs with left AAAs completely embolized and fine collateral vessels connecting to the distal brachial artery, in addition to bilateral multiple giant CAAs without stenoses. The patient was given intravenous prostaglandin for ten days to allow for formation of collateral circulation, as well as aspirin, low molecular weight heparin (which was switched to warfarin before discharge) and metoprolol. At discharge, the temperature and movement of his left upper limb improved significantly. On follow-up at three months, his left limb improved and was similar to the right with no cardiovascular event having occurred. The images of CAAs and AAAs on ultrasound and computerized tomography remained the same.Conclusions: This case highlights the importance of evaluating peripheral SAAs in KD patients with CAA, even if their clinical course appears uncomplicated. For both large non-aortic SAAs and CAAs in KD patients, antithrombotic therapy is of utmost importance.
Stretch-Induced Lncrna SNHG8 Inhibits Osteogenic Differentiation by Regulating EZH2 in Hpdlscs
Authors: Zhang Zijie , He Qin , Zhao Xiaolu , Li Xiaoyu , Wei Fulan 
Published: March 2021

Abstract
Background: Periodontal ligament stem cells (PDLSCs) are important for the remodeling of the alveolar bone while tooth moving. However, the effect of long non-coding RNA (lncRNA) on osteogenic differentiation of PDLSCs under mechanical force remains unclear.Methods: In this study, we compared stretched and non-stretched PDLSCs by high-throughput sequencing. The verification and selection of lncRNAs were achieved by quantitative reverse transcription polymerase chain reaction (qRT-PCR). PDLSCs osteogenic differentiation potentials were assessed by alkaline phosphatase (ALP) staining, Alizarin Red staining, qRT-PCR, and western blot. The application of mechanical force used Flexcell-FX-6000-Tension System in vitro, and constructing rats’ tooth movement model in vivo. To verify the osteogenic regulation ability of small nucleolar RNA host gene 8 (SNHG8), PDLSCs were stretched or applied osteogenic induction after been infected by lentivirus. RNA fluorescence in situ hybridization, isolation of nuclear and cytoplasmic RNA, qRT-PCR and western blot were performed to locate SNHG8. Western blot and qRT-PCR to find the relationship between enhancer of zeste homolog 2 (EZH2) and SNHG8.Results: Our results demonstrated that among lncRNAs altered screened by high-throughput sequencing, the expression level of SNHG8 steadily decreased after being stretched. Analysis of mRNA expression and protein levels revealed an upregulation of ALP and RUNX2, ALP and Alizarin Red staining showed more obvious alkaline phosphatase and more mineralized nodules in SNHG8 knockdown PDLSCs. In vivo experiments showed lower expression of the homologous gene of SNHG8 after tooth movement, and better ability of ectopic osteogenesis after knockdown SNHG8. The verification of SNHG8’s nuclear location led us to infer that SNHG8 may interact with EZH2. The qRT-PCR and western blot results disclosed EZH2 expression reduced along with the knockdown of SNHG8. Furthermore, knockdown of EZH2 lead to PDLSCs’ osteogenic differentiation ability increasing under osteogenic induction according to the mRNA level of ALP and RUNX2 accompanied by ALP and Alizarin Red staining results.Conclusion: In general, our study confirmed that mechanically sensitive lncRNA SNHG8 can influence the osteogenic differentiation of PDLSCs through epigenetic pathways without directly encoding protein, which provides solid evidence for the regulation by non-coding genes.
Partial characterization of Prunus Necrotic Ringspot Virus on apple in EGYPT&nbsp;
Authors: Abdel-Salam Aly M. , Mokbel Samah A. 
Published: March 2021

Abstract
A severe isolate of Prunus necrotic ringspot virus (PNRSV) was isolated from apple orchards in the vicinity of Nubaria city, Beheira governorate, Egypt. Infected-apple trees showed chlorotic, necrotic ringspots, and shoot holes on leaves. Severely infected- trees withered, became useless, and were removed causing severe economic losses. Reverse transcriptase (RT) polymerase chain reaction (PCR), RT-PCR, using degenerate primer pair for the coat protein (CP) gene of Ilarvirus amplified products similar to those produced from peach and apricot isolates of PNRSV-infecting stone fruits). Dot blotting immuno-binding assay (DBIA showed a positive reaction between PNRSV-infected apple sap and an Egyptian antiserum for PNRSV. Purified preparation from infected leaves, using the electro-elution technique yielded nucleoprotein, which had Amax and Amin at 260 and 240 nm respectively. Electron microscopy examination showed spherical virions with ca. 26 nm in diameter.
Communication Processes about Predictive Genetic Testing within High-Risk Breast Cancer Families: A Two-Phase Study Design
Authors: Blomen Chiara Lena , Pott Aliaksandra , Volk Alexander E. , Budäus Lars , Witzel Isabell 
Published: March 2021

Abstract
Background: The detection of a pathogenic variant in the BRCA1 or BRCA2 gene has medical and psychological consequences for both, affected mutation carriers and their relatives. This study analyzed the psychological impact of genetic testing and mutation-positive test result as well as associated family communication processes from the perspective of BRCA1 or BRCA2 mutation carriers and their family members.Methods: We conducted a two-phase study with explanatory sequential mixed methods design to understand the perspective of psychological process regarding genetic testing more efficiently. First, we analyzed a survey data of 79 carriers of a BRCA1 or BRCA2 mutation. Second, we conducted focus group interviews of 10 family members to deepen understanding of communication processes in high-risk families.Results: The average age of the BRCA1 or BRCA2 mutation carriers was 48 years, 58% had a history of cancer. The majority (64.6%) had general psychological distress independent of cancer diagnosis in the patients’ history. The point prevalence of depression was 16.9%. The main motives for undergoing genetic testing were desire for safety, prevention and risk assessment for the own children. The mutation carriers were satisfied with the decision to undergo genetic testing. Contrary to their subjective perception, the respondents' knowledge about those mutations was moderate. The familial communication was merely partially successful. In contrast to the high rate of disclosure to at-risk relatives (100%), the reported uptake of genetic testing among informed at-risk relatives was low (45.6%). In-depth focus group interviews with 10 family members revealed significant barriers to accessing genetic counseling including anxiety, uncertainty about the benefits of testing and the own cancer risk, particulary among males.Conclusion: The detection of a BRCA1 or BRCA2 mutation has psychological impact not only on mutation carriers but also on their family members. An adequate knowledge of the genetic background is required to reduce the level of psychological distress and to support the familial communication process. Therefore, the quality of information sources for affected individuals and relatives and also the awareness of health care professionals have to be improved.
ANALYSIS OF POSITION AND ROTATION DIRECTION OF DOUBLE STIRRER ON CHAOTIC ADVECTION BEHAVIOR
Authors: Susilo Sugeng Hadi , Asrori Asrori 
Published: March 2021

Turbulent mixing can damage the material molecules because of turbulence. Whereas laminar mixing raises a problem when mixing is carried out on viscous liquids. The mixing mechanism using chaotic flow affects the mixing quality. The aim of the experiment was to determine the position and direction of the double stirrer chaotic mixer. The installation of a chaotic mixer uses a cylindrical tub and two different mixers consisting of a primary mixer (Pp) and a secondary mixer (Ps). Periodically rotate the container and stirrer. The center of the vessel and primary mixer are placed at the same coordinates. For ε=4 cm (Pp to Ps distance), there are three experiments, namely: vessel rotation and directional stirrer (P2S-a), vessel rotation and opposite stirrer (P2B-a), and vessel rotation, both primary and secondary stirrers are directional variations. (P2V-a). Eccentricity 7 cm, there are also three treatments as above: one direction (P2S-b), reverse direction (P2B-b), and variation of direction (P2V-b).
The video camera recordings are processed digitally. Qualitative data show a pattern of behavior during mixing. Meanwhile, quantitative data is used to determine the level of mixing effectiveness. The results showed that the direction of rotation of the two cylinders had no effect on the effectiveness of chaotic mixing. Based on the number of initial droplets of dye, the treatment that experienced the fastest chaos was P2B-b, at n=2 and r=3.5303. The difference in the number of color droplets does not affect chaotic behavior. The highest mixing efficiency was generated by the lowest P2V-b mixing index value of 0.94. Simultaneously, the direction between the mixer and the container will provide maximum mixing efficiency. Isolated mixing areas (island) and areas of poor mixing occur because of one-way rotation and low eccentricity
IMPLEMENTATION OF CHORDAL RING NETWORK TOPOLOGY TO ENHANCE THE PERFORMANCE OF WIRELESS BROADBAND NETWORK
Authors: Attrah Nibras Habeeb , Abdul-Majeed Ghassan H. , Abdullah Mahmood Zaki 
Published: March 2021

The expansion of networks involved higher jump on the users utilizing the networks resources, which may require extra higher bandwidth. Due to the development of technology especially those folded under the Internet of Things (IoT), the new demand of higher data rate is been witnesses among the users. In order to feed the demand of users with high data rate, broadband networks are required where high data rate can be ensured for each user. Broadband networks can be established using optical network that carries the data through wide broadband. Areas such as rural and forests sides which are witnessing plenty of natural obstacles such as mountains, trees, seas, etc. are forming big challenge for propagating a cable (wire) or optical network.
Due to the limitations of the wire network, World Interoperability for Microwave Access (WiMAX) technology has been introduced as substitution for the broadband network. Such kind of alternative can be deployed through any geographical area without concerning on the wire paths. WiMAX preserved large coverage area and hence it may not suffer from the signal hand-off as in the case of another wireless network. In this project, Chordal Ring network topology is implemented to enhance the performance of wireless broadband network. With different routing protocols such as Destination Sequenced Distance Vector Protocol (DSDV) and Ad hoc On Demand Distance Vector (AODV), the network performance was examined for various Chordal Ring degree (e.g. fourth degree and fifth degree). Performance metrics such as number of transmitted packets, number of received packers, delivered packet rate (PDR), total number of drop packers (DP) and average queuing delay (been measured). Finally, the obtained results had been shown that fifth-degree Chordal Ring network is outperforming through DSDV routing protocol
Transverse vibration analysis of wire rope in deep mining hoisting system
Authors: Wu Shuiyuan , He Ping , Gong Xiansheng 
Published: March 2021

In this paper, the transverse vibration displacement, velocity and acceleration of the wire rope of deep mining hoisting system is acquired by establishing a mathematical model and solving it by Galerkin discrete method. The results show that: for the deep mining hoisting system with hoisting depth of 1000m and hoisting load of 25 t, when there is an excitation with amplitude of 0.002 m and frequency of 10 Hz at one end, the transverse vibration displacement of the wire rope at 200 m is between -0.015 m and 0.015 m, the transverse vibration velocity is between –0.05 m/s and 0.05 m/s, and the transverse vibration acceleration is between –0.5 m/s2 to 0.5 m/s2. Meanwhile, it can be found that different loads, accelerations and mass of wire rope per unit length have little influence on the transverse vibration displacement of the wire rope, but different external excitation frequency have an impact on the transverse vibration displacement of the wire rope. Then the vibration energy and natural frequencies are analyzed. And the maximum vibration energy and 30 natural frequencies are obtained. Finally, the mathematical model is verified through the experiment and the validity of the mathematical model is proved.
Coupling of the coagulation/flocculation and the anodic oxidation processes for the treatment of textile wastewater
Authors: Bouznif Sourour , Bali Mahmoud 
Published: March 2021

Abstract
The increased demand for textile products leads to an increase in the quantity of wastewater discharged. It becomes indeed one of the most critical health and environmental problems in the world. The main challenge, therefore, is to develop innovative techniques for treating this wastewater with low production costs and better efficiency. The major objective of this work was to investigate the efficiency of the coupling of the coagulation–flocculation and the anodic oxidation processes on the platinum electrode in the removal of organic, mineral, and microbial pollution contained in textile effluents. A series of experiments is carried out on samples prepared in the laboratory, in which the textile effluent was mixed with a secondary effluent from an urban wastewater treatment plant. The treatment consists of two steps: a coagulation–flocculation process using aluminum salts as a coagulant and an anodic oxidation on the platinum electrode using photovoltaic panels for the production of electric current. The treatment at optimized conditions reveals that the coupling of the two processes made it possible to achieve satisfactory results. The abatement rates were 95.97% for the turbidity, 90% for COD, 100% for BOD, 100% for , 53.6% for , and 100% for . The coupling of the two processes ensured the complete elimination of fecal germs. Thanks to the satisfactory results, the obtained permeate can be reused in the dyeing process in the textile industry.
High flux membrane based on in-situ formation of zirconia layer coated the polyethersulfone substrate for ions separation
Authors: Worou Chabi Noël , Kang Jing , Alamou Eric A. , Degan Arcadius , Yan Pengwei , Gong Yingxu , Guene Razack L. , Chen Zhonglin 
Published: March 2021

Abstract
A flawless, extremely loose, membrane, efficient for multivalent ions separation, has been successfully synthesized by the in-situ formation approach. The as-synthesized nanofiltration (NF) membrane, NF_PES-Zr, proceeded from a thin film layer of nanoparticles (NPs) zirconium that coated the platform of the polyethersulfone (PES) ultrafiltration (UF) membrane through a bio-glue made from dopamine hydrochloric and sodium bicarbonate buffer. The estimation of the average pore size of the novel organic-inorganic NF membrane NF_PES-Zr using the filtration velocity approach of Guerout-Elford-Ferry was close to 0.9 nm. NF_PES-Zr membrane holds a record in permeate water flux release of about 62.5 and was revealed to be effective for multivalent ions separation. A 5 days-test performed on NF_PES-Zr demonstrated its long-term stability and showed a rejection rate of 93.4% and 37.8% respectively for and .
Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis,
Mechanisms and Potential Treatments
Authors: Du Yi , Li Kaijun , Liu Wei , Song Ruitong , Luo Meifeng , He Jianfeng , Xu Xiaoyu , Qu Xiaosheng 
Published: March 2021

:
Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and disability rates are high. In the present work, we review recent advances in the diagnosis and treatment of patients with NMOSD, as well as the pathogenesis and mechanisms of AQP4-IgG-seropositive NMOSD.
A New Silver Nano-Formulation of Cassia auriculata Flower Extract and
its Anti-Diabetic Effects
Authors: Berlin Grace Viswanathan Mariammal , Wilson Devarajan David , M Divyadharshini , S Viswanathan , Siddikuzzaman  , Gopal ‪Rengaswamy 
Published: March 2021

Background:
Treatment of diabetes mellitus (DM) using plant based drugs is advancing
and getting much attention in recent years. Cassia auriculata L. is widely used in Indian folk
medicine for the treatment of DM. Site-specific targeted plant drug delivery by metallic nanoparticles
carriers is a new emerging procedure under research due to its enhanced bioavailability and
reduced toxicity. This study was therefore aimed at biosynthesizing a new silver nanoparticle of
Cassia auriculata L. flower extract and study its anti-diabetic efficiency in rats.

Methods:
The silver nanoparticles were biosynthesized using AgNO3 solution and characterized
by spectroscopy, SEM and EDAX analyses. The acute toxicity of this nano-preparation (up to
2000 mg/kg b. wt) was analyzed in rats and the anti-diabetic efficiency (for 50 mg/kg.b.wt and 200
mg/kg.b.wt) was studied in Streptozotocin induced diabetic rats. The diabetic parameters such as;
blood glucose, serum protein, liver glycogen, serum lipid profile, serum levels of creatinine, urea,
ALT, AST and ALP were analyzed. The histology of the liver, kidney and pancreas was evaluated
after staining with Haematoxylin and Eosin.

Results:
The increased blood glucose in Streptozotocin induced diabetic rats was found to be significantly
reduced (p<0.01) in the treated group of rats. The characteristic damage and disorganization
in the cells of Streptozotocin induced DM was found to be recovered in the treated group of
rats. The alterations in the lipid profile, hyperglycaemia, reduced serum protein and liver glycogen,
enhanced liver function and kidney function markers observed in the rats of DM control
group were normalized in the treated group of rats.

Conclusion:
The results of this study, proving an efficient anti-diabetic activity of the biosynthesized
silver nanoparticles of Cassia auriculata L. flower extract, implies that this nano-preparation
may be exploited as an alternative biopharmaceutical agent for treating DM.
Formulation and Evaluation of α-Pinene Loaded Self-emulsifying
Nanoformulation for In-Vivo Anti-Parkinson's Activity
Authors: Srivastava Rajnish , Choudhury Pratim K. , Dev Suresh Kumar , Rathore Vaibhav 
Published: March 2021

Aim:
The present study was aimed to developed and optimize the self-nano emulsifying
drug delivery system of α-pinene (ALP-SNEDDS) and evaluate its in-vivo anti-Parkinson's activity.

Background:
Different lipid-based drug delivery technologies have been researched to upgrade drug
bioavailability and expand their clinical adequacy upon oral administration. Self-emulsifying drug delivery
systems (SEDDS) have pulled in developing the interest specifically for self nano emulsifying
drug delivery systems (SNEDDS).

Objective:
The present work was attempted to improve the bioavailability of the ALP by defining the
role of self-nano emulsifying formulations for its neuroprotective effect.

Method:
Miscibility of the ALP was estimated in various excipient components to select the optimized
combination. Self-nano emulsification, thermodynamic stability, the effect of dilution on robustness,
optical clarity, viscosity, and conductivity tests were performed. The in-vivo anti-Parkinson's
activity of the ALP-SNEDDS formulations were done using Pilocarpine antagonism induced Parkinsonism
in rodents. Behavioral tests like tremulous jaw movements, body temperature, salivation, and
lacrimation are performed.

Result:
Two optimized formulations, composed of Anise oil, Tween 80, and Transcutol-HP of Oil:
Smix ratio (4:6 and 3:7) were selected. The Smix ratio for both the formulation was 2:1. The particle
size was found to consistent with the increase in dilution. The mean negative zeta potential of the formulations
was found to be increased with an increase in dilution. The TEM images of the formulations
revealed spherical shape of the droplet. The in-vitro drug release profile was found to be significant as
compared to plain ALP suspension.

Conclusion:
The results of in-vivo studies indicate that nanosizing and enhanced solubilization of oral
ALP-SNEDDS formulations significantly improved the behavioral activities compared to plain ALP
suspension.