bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of permeability heterogeneity on water-alternating-gas displacement in highly stratified heterogeneous reservoirs
Authors: Khan Mohammad Yunus , Mandal Ajay 
Published: October 2021

AbstractAvailability of gases at the field level makes attractive to water-alternating-gas (WAG) process for low viscosity and light oils carbonate reservoir. However, impact of reservoir heterogeneity on WAG performance is crucial before field application. In general, ramp carbonates have heterogeneity due to variation of permeability and porosity. However, WAG performance significantly affected by permeability variations. This article investigates merits and demerits of WAG displacement due to permeability heterogeneities such as permeability anisotropy, high permeability streaks (HKS), matrix permeability, dolomite and thin dense stylolite layers. High-resolution compositional simulations with tuned equation of state (EoS) were carried out using 2D and 3D sector models. The study focuses on WAG performance in terms of oil recovery, vertical sweep, solvent utilization, gas oil ratio (GOR), water cut (WCT), WAG response time, gravity override, hysteresis, un-contacted oil saturation and economics. The results of simulation show that the heterogeneous reservoir provides initially faster WAG response, lower expected ultimate recovery (EUR), faster gas breakthrough, higher GOR and WCT production compared to homogeneous reservoir. The gas gravity override at smaller wells spacing is less in homogeneous reservoir as compared to heterogeneous reservoir, but it is reverse in case of larger well spacing. In heterogeneous reservoir, the HKS shows significant gas override resulting in poor vertical sweep due to capillary holding, and the high permeability dolomite layer shows early water breakthrough. This reservoir has higher solvent utilization in initial stage, and then, it becomes nearly equal to homogeneous reservoir. Simulation in both reservoirs overestimates incremental recovery of 2–3% OOIP at one pore volume injection because of not involving un-contacted oil saturation as predicted in core flood. The findings of this study will help to understand WAG performance and design in highly heterogeneous reservoirs for field applications.
Graphical abstract
Colorectal cancer promoter methylation alteration affects the expression of glutamate ionotropic receptor AMPA type subunit 4 alternative isoforms potentially relevant in colon tissue
Authors: Vega-Benedetti Ana Florencia , Loi Eleonora , Moi Loredana , Restivo Angelo , Cabras Francesco , Deidda Simona , Pretta Andrea , Ziranu Pina , Orrù Sandra , Scartozzi Mario , Zorcolo Luigi , Zavattari Patrizia 
Published: October 2021

AbstractDNA methylation alterations are early events during tumourigenesis, affecting genes involved in the crosstalk between cells and surroundings in colorectal cancer (CRC). Among these genes, GRIA4, Glutamate Ionotropic Receptor AMPA Type Subunit 4, displays hypermethylation in the promoter region, and is an early diagnostic biomarker. It is well known that methylation can also affect alternative transcription. The purpose of this study is to evaluate the expression, at transcript and protein level, of GRIA4 main isoforms (the canonical one and a short variant) in 23 CRC and matched normal samples, of which we previously verified the methylation status. We further predicted miRNA/transcript target interactions as a possible post-transcriptional regulation using bioinformatics tools. As expected, downregulation of both variants has been observed in tumours. Interestingly, in contrast to what observed at transcriptional level, the GluR4 protein short isoform displayed higher expression than the canonical one either in normal or tumoural tissues. This may be explained by miRNA specifically targeting the canonical isoform. Our study is the first one that shows the expression of both isoforms in colon tissues. To note, the evident expression of the short isoform suggests a functional role in intestinal cell biology.
Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak
Authors: Saadeh Marguerita , Calderón-Larrañaga Amaia , Vetrano Davide Liborio , von Rosen Philip , Fratiglioni Laura , Welmer Anna-Karin 
Published: October 2021

Abstract
Background
One’s physical function and physical activity levels can predispose or protect from the development of respiratory infections. We aimed to explore the associations between pre-pandemic levels of physical function and physical activity and the development of COVID-19-like symptoms in Swedish older adults.

Methods
We analyzed data from 904 individuals aged ≥ 68 years from the population-based Swedish National study on Aging and Care in Kungsholmen. COVID-19-like symptoms were assessed by phone interview (March–June 2020) and included fever, cough, sore throat and/or a cold, headache, pain in muscles, legs and joints, loss of taste and/or odor, breathing difficulties, chest pain, gastrointestinal symptoms, and eye inflammation. Muscle strength, mobility, and physical activity were examined in 2016–2018 by objective testing. Data were analyzed using logistic regression models in the total sample and stratifying by age.

Results
During the first outbreak of the pandemic, 325 (36%) individuals from our sample developed COVID-19-like symptoms. Those with slower performance in the chair stand test had an odds ratio (OR) of 1.5 (95% confidence interval [CI] 1.1–2.1) for presenting with COVID-19-like symptoms compared to better performers, after adjusting for potential confounders. The association was even higher among people aged ≥ 80 years (OR 2.6; 95% CI 1.5–4.7). No significant associations were found between walking speed or engagement in moderate-to-vigorous physical activity and the likelihood to develop COVID-19-like symptoms.

Conclusion
Poor muscle strength, a possible indicator of frailty, may predispose older adults to higher odds of developing COVID-19-like symptoms, especially among the oldest-old.
Probabilistic measures of edge criticality in graphs: a study in water distribution networks
Authors: Ponti Andrea , Candelieri Antonio , Giordani Ilaria , Archetti Francesco 
Published: October 2021

AbstractThe issue of vulnerability and robustness in networks have been addressed by several methods. The goal is to identify which are the critical components (i.e., nodes/edges) whose failure impairs the functioning of the network and how much this impacts the ensuing increase in vulnerability. In this paper we consider the drop in the network robustness as measured by the increase in vulnerability of the perturbed network and compare it with the original one. Traditional robustness metrics are based on centrality measures, the loss of efficiency and spectral analysis. The approach proposed in this paper sees the graph as a set of probability distributions and computes, specifically the probability distribution of its node to node distances and computes an index of vulnerability through the distance between the node-to-node distributions associated to original network and the one obtained by the removal of nodes and edges. Two such distances are proposed for this analysis: Jensen–Shannon and Wasserstein, based respectively on information theory and optimal transport theory, which are shown to offer a different characterization of vulnerability. Extensive computational results, including two real-world water distribution networks, are reported comparing the new approach to the traditional metrics. This modelling and algorithmic framework can also support the analysis of other networked infrastructures among which power grids, gas distribution and transit networks.
Basic Creep-Fatigue Models Considering Cavitation
Authors: Sandström Rolf 
Published: October 2021

AbstractCavitation plays a central role during creep-fatigue. During recent years, fundamental models for initiation and growth of creep cavities that do not involve any adjustable parameters have been developed. These models have successfully been used to predict creep rupture data for austenitic stainless steels again without using adjustable parameters. However, it appears that basic models have not yet been applied to creep-fatigue assessments. A summary of the fundamental cavitation models is given. A model for monotonous deformation is transferred to cyclic loading. The parameter values are kept except that the dynamic recovery constant is raised due to increased interactions between dislocations during cycling. This model is successfully compared with observed LCF and TMF hysteresis loops. A new model for cavity growth due to plastic deformation is presented. The model is formulated in such a way that the condition for constrained growth is automatically satisfied. In this way, it is avoided to overestimate the growth rate.
Presence, Absence, and Alterity: Fire Space and Goffman’s Selves in Postdigital Education
Authors: Gourlay Lesley 
Published: October 2021

AbstractThe literature on space in higher education has arguably been dominated by the concept of ‘learning spaces’. In this paper, I will argue that this construct, while appearing student-focused and creative, is ideologically circumscribed by an underlying social constructivism. Following Bayne et al. (2014), I draw on science and technology studies to consider social topologies, in particular regional space,network space, and their proposedfluid space, and the work of Law and colleagues on the category offire space, derived from Bachelard’s (The Psychoanalysis of Fire, 1964) disquisition on the nature of fire. I work with this construct in an analysis of postdigital education, in particular looking at synchronous interaction via video conferencing software such as Zoom. Linking this analysis to the work of Goffman and his concept of the lecturerselves(Goffman inForms of Talk, 1981), I argue that the concept offire spacemay allow for a more nuanced and accurate account of the flickering, contingent nature of (co) presence, absence, and alterity, allowing for a more immanent account of digital interaction in ‘distance’ or ‘online’ education.
Steam gasification of municipal solid waste for hydrogen production using Aspen Plus® simulation
Authors: Shafiq Hamza , Azam Shakir Ul , Hussain Arshad 
Published: October 2021

AbstractApproximately 50 million ton of municipal waste is generated in Pakistan per annum and most of this waste does not reach final deposit sites. In this research, Silvia gas technology for municipal solid waste (MSW) steam gasification is studied to produce high energy density product gas. A detailed simulation model is developed with the help of Aspen Plus®. Catalyst coal bottom ash along with lime (CaO) as sorbent is employed for tar reduction and improving the hydrogen (H2) yield in the product gas. The effect of gasification operating temperature and the ratio of steam to feedstock on synthetic gas composition, hydrogen (H2) yield and heating values of synthesis gas was studied. Coal bottom ash along with CaO had a substantial effect on hydrogen (H2) yield and synthesis gas production. Rise in steam–MSW ratio increased the hydrogen (H2) from 58 to 74.9% (vol.). The maximum value of hydrogen (H2) production, i.e., 74.9% by vol. was achieved at a steam–feedstock ratio of 1.9. A maximum of 79.8% by vol. hydrogen (H2) was attained at 680 °C gasification operating temperature with 1.3 ratio of steam to feedstock and coal bottom ash 0.07% by wt. High value of 13.1 MJ/Nm3 of hydrogen-rich synthetic gas was achieved at 680 °C. The acquired results lay the foundation for the economic feasibility study and pilot plant for MSW usage for hydrogen production.
Arterial Blood Gas and Rotational Thromboelastometry Parameters in Healthy Rescuers Incidentally Exposed to Nitroglycerin, Nitrogen Compounds, and Combustion Products
Authors: Petrucci Emiliano , Cofini Vincenza , Pizzi Barbara , Necozione Stefano , Marinangeli Franco 
Published: October 2021

Introduction Acute exposure to nitrogen compounds combined with a massive inhalation of air pollutants can influence respiratory and cardiovascular symptoms and coagulation abnormalities in accidentally exposed healthy adults during cave detonation operations. Methods Italian alpine and cave rescuers widened a cave in the Abisso Luca Kralj in Trieste, Italy. Volunteers inside the cave were accidentally exposed to the fumes from an uncontrolled detonation of blasting gelatin microcharges. We performed a retrospective cohort study on the clinical data, arterial blood gas analysis, and rotational thromboelastometry parameters from the rescuers involved in the accident. Results Ninety-three healthy rescuers were involved in the uncontrolled detonation: 47 volunteers handled a mixture of nitrogen compounds (blaster group), and 46 volunteers did not (nonblaster group). After the accident, statistically significant differences ( P<0.05) in arterial blood gas values were observed between the groups, with a pattern of mild respiratory acidosis with hypercapnia in the nonblaster group and severe mixed acid-base disorder with hypoxia and hypercapnia in the blaster group. Mild hyperfibrinolysis was observed in 44 volunteers in the blaster group, as were associated bleeding symptoms in 34 volunteers; no significant coagulation modifications were recorded in the nonblaster group. Conclusions Respiratory acidosis with hypoxia, hypercapnia, a compensatory metabolic response, and mild hyperfibrinolysis were probably related to the combined effect of nitrogen compounds and the inhaled toxic products of detonation. Therefore, each element exerts a determinant effect on promoting the biological toxicity of the others.
Intelligent Recognition of Ore‐Forming Anomalies Based on Multisource Data Fusion: A Case Study of the Daqiao Mining Area, Gansu Province, China
Authors: Cai Huihui , Chen Siqiong , Xu Yongyang , Li Zixuan , Ran Xiangjin , Wen Xingping , Li Yongsheng , Men Yanqing 
Published: October 2021

AbstractNovel prediction methods using artificial intelligence have been developed to improve the identification, discovery, and utilization of new types of mineral resources at new depths or using new technologies. However, most artificial intelligence methods require large training data sets that are often unavailable for mineralization prediction models, leading to inaccuracies. To address this issue, we developed a semi‐supervised machine‐learning method to identify metallogenic anomalies using the density‐based spatial clustering of applications with noise method and autoencoder. The outputs of this method show irregularity in distributions inferred from geological, geochemical, and hyperspectral remote sensing data that match known mineralization locations. We focus on the Daqiao mining area of Gansu Province in China to show that the model predictions are highly consistent with known deposits of the Yinmahe and Daqiao gold mines, and two new prospecting areas have been highlighted for further field confirmation. The accuracy of this semi‐supervised learning method was verified by an interdisciplinary intelligent analysis, showing that this method could have wide‐reaching applications for improving regional geological surveys.
Tectonic Inheritance During Plate Boundary Evolution in Southern California Constrained From Seismic Anisotropy
Authors: Schulte‐Pelkum Vera , Becker Thorsten W. , Behr Whitney M. , Miller Meghan S. 
Published: October 2021

AbstractThe style of convective force transmission to plates and strain‐localization within and underneath plate boundaries remain debated. To address some of the related issues, we analyze a range of deformation indicators in southern California from the surface to the asthenosphere. Present‐day surface strain rates can be inferred from geodesy. At seismogenic crustal depths, stress can be inferred from focal mechanisms and splitting of shear waves from local earthquakes via crack‐dependent seismic velocities. At greater depths, constraints on rock fabrics are obtained from receiver function anisotropy, Pn and P tomography, surface wave tomography, and splitting of SKS and other teleseismic core phases. We construct a synthesis of deformation‐related observations focusing on quantitative comparisons of deformation style. We find consistency with roughly N‐S compression and E‐W extension near the surface and in the asthenospheric mantle. However, all lithospheric anisotropy indicators show deviations from this pattern. Pn fast axes and dipping foliations from receiver functions are fault‐parallel with no localization to fault traces and match post‐Farallon block rotations in the Western Transverse Ranges. Local shear wave splitting orientations deviate from the stress orientations inferred from focal mechanisms in significant portions of the area. We interpret these observations as an indication that lithospheric fabric, developed during Farallon subduction and subsequent extension, has not been completely reset by present‐day transform motion and may influence the current deformation behavior. This provides a new perspective on the timescales of deformation memory and lithosphere‐asthenosphere interactions.
Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer
Authors: Yu Chune , Luo Dan , Yu Jing , Zhang Min , Zheng Xiaobo , Xu Guangchao , Wang Jiaxin , Wang Huiling , Xu Yufei , Jiang Ke , Xu Jie , Ma Xuelei , Jing Jing , Shi Hubing 
Published: October 2021

AbstractTargeting the KRAS pathway is a promising but challenging approach for colorectal cancer therapy. Despite showing potent efficacy in BRAF-mutated melanoma, MEK inhibitors appeared to be tolerated by colorectal cancer cells due to their intrinsic compensatory signaling. Here, we performed genome-wide CRISPR/Cas9 screening in the presence of MEK inhibitor to identify genes that are synthetically lethal with MEK inhibition in CRC models harboring KRAS mutations. Several genes were identified as potential functional drivers, which were significantly enriched in the GRB7-mediated RTK pathway. Loss-of-function and gain-of-function assays validated that GRB7 potently rendered CRC cells primary resistance to MEK inhibitors through the RTK pathway. Mass spectrum analysis of GRB7 immunoprecipitates revealed that PLK1 was the predominant interacting kinase of GRB7. Inhibition of PLK1 suppressed downstream signaling of RTK, including FAK, STAT3, AKT, and 4EBP1. The combination of PLK1 and MEK inhibitors synergistically inhibited CRC cell proliferation and induced apoptosis in vitro and in vivo. In conclusion, we identified GRB7-PLK1 as a pivotal axis mediating RTKs, resulting in MEK inhibitor tolerance. PLK1 is therefore a promising target for synergizing MEK inhibitors in the clinical treatment of CRC patients harboring KRAS mutations.
Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
Authors: Penack Olaf , Peczynski Christophe , Mohty Mohamad , Yakoub-Agha Ibrahim , de la Camara Rafael , Glass Bertram , Duarte Rafael F. , Kröger Nicolaus , Schoemans Hélène , Koenecke Christian , Peric Zinaida , Basak Grzegorz W. 
Published: October 2021

AbstractRisk assessment of allogeneic hematopoietic cell transplantation (allo-HCT) is hindered by the lack of current data on comorbidities and outcome. The EBMT identified 38,760 allo-HCT recipients with hematologic malignancies transplanted between 2010 and 2018 from matched sibling and unrelated donors with a full data set of pre-existing comorbidities. Multivariate analyses using the Cox proportional-hazards model including known risk factors for non-relapse mortality (NRM) were performed. We found that pre-existing renal comorbidity had the strongest association with NRM (hazard ratio [HR] 1.85 [95% CI 1.55–2.19]). In addition, the association of multiple pre-existing comorbidities with NRM was significant, including diabetes, infections, cardiac comorbidity, and pulmonary comorbidity. However, the HR of the association of these comorbidities with NRM was relatively low and did not exceed 1.24. Consequently, the risk of NRM was only moderately increased in patients with a high hematopoietic cell transplantation comorbidity index (HCT-CI) ≥ 3 (HR 1.34 [1.26–1.42]). In the current EBMT population, pre-existing non-renal comorbidities determined NRM after allo-HCT to a much lesser extent as compared with the underlying HCT-CI data. Improvements in management and supportive care as well as higher awareness based on the use of HCT-CI may have contributed to this favorable development.
TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis
Authors: Hu Jianyang , Lai Yuni , Huang Hao , Ramakrishnan Saravanan , Pan Yilin , Ma Victor W. S. , Cheuk Wah , So Grace Y. K. , He Qingling , Geoffrey Lau C. , Zhang Liang , Cho William C. S. , Chan Kui Ming , Wang Xin , Rebecca Chin Y. 
Published: October 2021

Abstract
Background
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. By performing multiomic profiling, we recently uncovered super-enhancer heterogeneity between breast cancer subtypes. Our data also revealed TCOF1 as a putative TNBC-specific super-enhancer-regulated gene. TCOF1 plays a critical role in craniofacial development but its function in cancer remains unclear.

Methods
Overall survival and multivariant Cox regression analyses were conducted using the METABRIC data set. The effect of TCOF1 knockout on TNBC growth and stemness was evaluated by in vitro and in vivo assays. RNA-seq and rescue experiments were performed to explore the underlying mechanisms.

Results
TCOF1 is frequently upregulated in TNBC and its elevated expression correlates with shorter overall survival. TCOF1 depletion significantly inhibits the growth and stemness of basal-like TNBC, but not of mesenchymal-like cells, highlighting the distinct molecular dependency in different TNBC subgroups. RNA-seq uncovers several stem cell molecules regulated by TCOF1. We further demonstrate that KIT is a downstream effector of TCOF1 in mediating TNBC stemness. TCOF1 expression in TNBC is regulated by the predicted super-enhancer.

Conclusions
TCOF1 depletion potently attenuates the growth and stemness of basal-like TNBC. Expression of TCOF1 may serve as a TNBC prognostic marker and a therapeutic target.