bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maling Bamboo (Yushania Maling) Overdominance Alters Forest Structure and Composition in Khangchendzonga Landscape, Eastern Himalaya
Authors: Gaira Kailash , Pandey Aseesh , Sinha Sheila , Badola Hemant , Lepcha Jhony , Dhyani Pitamber P. , Chettri Nakul 
Published: October 2021

Abstract
The Khangchendzonga Landscape (KL), a part of ‘Himalayan Biodiversity Hotspot’, is known for its unique biodiversity. In recent years the KL experiencing threats to biodiversity due to biological overdominance of native species such as Maling bamboo (Yushania maling). In the present study, we investigated the impacts of the overdominance of Y. maling on the forest composition of Singalila National Park (SNP), Eastern Himalaya, India. Elevational habitats 2400 to 3400 m asl were surveyed by laying 69 (10m x 10m) forest plots including 51 bamboo plots and 18 non-bamboo plots. Bamboo plots showed significantly (p<0.05) low species richness and density in both shrub and herb layers which further manifested the low seedling density. Generalized Additive Model (GAM) estimated a significant (p<0.0001) decline in species richness and density with increasing bamboo density in SNP. Our study projects the overdominance of Y. maling has a significant negative impact on forest structure and composition. Therefore, management of invasiveness of Y. maling is essential through its optimized removal and utilization in handicrafts to create ecological and economic benefits. Further long-term studies assessing the impacts of Y. maling overdominance on forest ecosystems and soil dynamics are recommended.
Elevated Expression of Urokinase Plasminogen Activator in Rodent Models and Patients With Cerebral Amyloid Angiopathy
Authors: Vervuurt Marc , Zhu Xiaoyue , Schrader Joseph , de Kort Anna , Marques Tainá , Kersten Iris , Ton Annemieke Peters van , Abdo Wilson , Schreuder Floris , Rasing Ingeborg , Terwindt Gisela , Wermer Marieke , Greenberg Steven , Klijn Catharina , Kuiperij Bea , Nostrand William Van , Verbeek Marcel 
Published: October 2021

Abstract
Objective: To study the association of urokinase plasminogen activator (uPA) with development and progression of cerebral amyloid angiopathy (CAA) in a rat model for CAA type-I (rTg-DI) and in patients with sporadic (sCAA) and Dutch-type hereditary CAA (D-CAA). Additionally, to investigate the potential of uPA to serve as a diagnostic biomarker of CAA in cerebrospinal fluid (CSF) from patients with sCAA and D-CAA.Methods: We studied the expression of uPA mRNA by qPCR and co-localization of uPA with amyloid-β (Aβ) using immunohistochemistry in the cerebral vasculature of rTg-DI rats compared to wild type (WT) rats and in an sCAA patient and control subject using immunohistochemistry. CSF levels of uPA were measured in rTg-DI and WT rats and in two separate cohorts of sCAA and D-CAA patients and controls, using enzyme-linked immunosorbent assays (ELISA).Results: The presence of uPA was clearly detected in the cerebral vasculature of rTg-DI rats and an sCAA patient, but not in WT rats or a non-CAA human control. uPA expression was highly co-localized with microvascular Aβ deposits. In rTg-DI rats, uPA mRNA expression was highly elevated at 3 months of age (coinciding with the emergence of microvascular CAA deposition) and sustained up to 12 months of age (with severe microvascular CAA deposition) compared to WT rats. CSF uPA levels were elevated in rTg-DI rats compared to WT rats (p=0.03), and in two separate, independent groups of sCAA patients compared to controls (after adjustment for age of subjects, p=0.05 and p=0.03). No differences in CSF uPA levels were found between asymptomatic and symptomatic D-CAA patients and their respective controls (after age-adjustment, p=0.09 and p=0.44).Conclusion: uPA expression appears linked to the onset of CAA in rTg-DI rats. Increased cerebrovascular expression of uPA in CAA correlates with increased quantities of CSF uPA in rTg-DI rats and human CAA patients, suggesting that uPA could serve as a biomarker for CAA. No differential expression levels of uPA in CSF of (a)symptomatic D-CAA patients were discovered. These studies also further support the use of rTg-DI rat models as a useful preclinical model for the study of human CAA type-I.
Study on Influencing Factors to HIV Health Services Among Men Who Have Sex with Men (MSM) from 2013 to 2021
Authors: Lin Bing , Liu Jiaxiu , Pan Hong , Ma Yingjie , Zhong Xiaoni 
Published: October 2021

Abstract
Background We assessed the utilization of HIV health services and its influencing factors on consistent condom use, HIV testing and HIV counseling among men who have sex with men (MSM) based on Andersen Behavioral Model, so as to provide a theoretical basis for future infectious disease prevention and control strategies and health services policy formulation.method This is a cross-sectional study from 2013 to 2021. A sample survey was conducted in southwest China including Chongqing, Sichuan, Xinjiang and Guangxi, and an anonymous self-administered questionnaire survey was conducted among MSM who met the requirements and were recruited. Based on Anderson Behavioral Model, the questionnaire divided the influencing factors into predisposing factor, enabling factor and need factor. There were 2908 valid questionnaires. Multivariate logistic regression analysis was used to explore the factors influencing the utilization of health services.Results In the survey of HIV health services, 36.49% of respondents consistently used condoms, 82.81% had HIV testing, and 65.61% had HIV counseling. It can be obtained that among the predisposing factor, older age is a factor that promotes HIV testing but is a hindrance to consistent condom use. Condom use was higher among MSM who were Ethnic Han and had an education level of "junior high or below". Among the enabling factor, not finding a sexual partner through the Internet, not having commercial sex were associated with consistent condom use. Urban and high income were enablers of HIV testing and HIV counseling. Among the need factor, improved HIV knowledge could promote HIV testing and HIV counseling among MSM.Conclusions For these groups, MSM with high-risk characteristics should be identified as a priority in the future public health services. HIV knowledge should be promoted in health education, and mental health diagnosis and treatment also should be strengthened.
Stabilization of 1D Solitons By Fractional Derivatives In Systems With Quintic Nonlinearity
Authors: Stephanovich V. A. , Olchawa W. 
Published: October 2021

Abstract
We study theoretically the properties of a soliton solution of the fractional Schrödinger equation with quintic nonlinearity. Under ”fractional” we understand the Schrödinger equation, where ordinary Laplacian (second spatial derivative in 1D) is substituted by its fractional counterpart with Lévy index α. We speculate that the latter substitution corresponds to phenomenological account for disorder in a system. Using analytical (variational and perturbative) and numerical arguments, we have shown that while in the case of Schrödinger equation with the ordinary Lapla-cian (corresponding to Lévy index α = 2), the soliton is unstable, even infinitesimal difference α from 2 immediately stabilizes the soliton texture. Our analytical and numerical investigations of ω(N) dependence (ω is soliton frequency and N its mass) show (within the famous Vakhitov-Kolokolov criterion) the stability of our soliton texture in the fractional α < 2 case. Direct numerical analysis of the linear stability problem of soliton texture also confirms this point. We show analytically and numerically that fractional Schrödinger equation with quintic nonlinearity admits the existence of (stable) soliton textures at 2/3 < α < 2, which is in accord with existing literature data. These results may be relevant to both Bose-Einstein condensates in cold atomic gases and optical solitons in the disordered media.
A Prognostic Signature Based on Immune-Related Genes Associated with Tumor Microenvironment for Cholangiocarcinoma
Authors: Zhang Rui , Chen Chen , Li Qi , Jin Zhechuan , Su Jingbo , Zhang Jian , Fu Jialu , Zhang Dong , Geng Zhimin 
Published: October 2021

Abstract
Background

Several studies indicate immune related genes (IRGs) dramatically correlates with tumorigenesis and progress of cancer. However, the association IRGs and the value in predicting the prognosis of cholangiocarcinoma (CCA) patients remains unclear. Thus, we aimed to discover reliable biomarkers based on IRGs signature to predict survival in CCA.
Methods

Gene expression profiles of CCA patients were collected from TCGA and GEO database. Univariate, multivariate and Lasso (Least absolute shrinkage and selection operator) Cox analysis was used to identify IRGs signature. Subsequently, a nomogram that predicts outcomes for CCA patients based on IRGs signature was constructed to visualize prognosis. We also explored the relationships between tumor-infiltrating immune cells (TIICs) and IRGs. GDSC database was used to explore potential targeted drugs. Tissue samples of 23 CCA patients were collected and qRT-PCR were employed to validate the mRNA level of IRGs.
Results

5 IRGs (AVPR1B, CST4, TDGF1, RAET1E and IL9R) were identified as robust indicators for OS. A prognostic model based on IRGs signature can significantly stratify patients into high-risk and low-risk groups. Meanwhile, ROC indicated that the risk model had satisfactory performance. We also observed that the risk score was an independent prognostic factor for OS and built a nomogram. The low-risk group had a significantly higher percentage of infiltrated macrophages M1 than the high-risk group. Through analyzing the GDSC database, the high-risk group demonstrated drug sensitivity to some targeted drugs such as AMG 706 and Thapsigargin. Finally, the results of qRT-PCR were consistent with bioinformatics analysis.
Conclusions

We established a novel IRGs signature to predict prognosis for CCA. The risk model exhibited excellent diagnostic efficiency in predicting OS.
LeukoSegmenter: A Double Encoder-decoder Based Network for Leukocyte Segmentation From Blood Smear Images
Authors: Dhalla Sabrina , Mittal Ajay , Gupta Savita 
Published: October 2021

Abstract
Segmentation of blood cells is a prerequisite step in automated morphological analysis of blood smear images, cell count determination and diagnosis of various diseases such as leukemia. It is extremely challenging due to different sizes, shapes, morphological characteristics and overlapping of blood cells. Due to its complicated nature, it is generally performed as a sequence of steps. However, sequential segmentation results in restricted accuracy due to cascading of errors that creep during each stage. On the contrary, pixel-wise segmentation of blood cells is a single step task and gives promising results. In this paper, we propose LeukoSegmenter, a double encoder-decoder for precise pixel-wise segmentation of leukocytes from blood smear images. It uses pre-trained ResNet18 based encoders and U-Net based decoders. Feature maps obtained from the first network are utilised as attention maps. These are used as input in conjunction with the original 3-channel image to obtain final mask from the second network. This mechanism allows the latter encoder-decoder pair to focus explicitly on leukocytes and ignore other blood cells and debris, thus improving the segmentation accuracy. Experiments on ALL-IDB1 dataset show that the proposed LeukoSegmenter achieves intersection-over-union score of 94.6827% and Dice score of 97.1987% which is superior than that of state-of-the-art methods.
Soft Tissue Defects of Neck and Shoulder Managed by Pedicled Latissimus Dorsi Myocutaneous Flap Transthoracic Transposition
Authors: Abula Abulaiti , Liu Yanshi , Cai Feiyu , Liu Kai , Ren Peng , Abulaiti Alimujiang , Maimaiti Xiayimaierdan , Yusufu Aihemaitijiang 
Published: October 2021

Abstract
BackgroundThe purpose of this study was to evaluate the effectiveness of latissimus dorsi myocutaneous flap in repairing neck and shoulder soft tissue defects combined with infection.MethodsA total of 11 patients with neck and shoulder soft tissue defects combined with infection, from July 2017 to December 2019, were treated by pedicled latissimus dorsi myocutaneous flap (PLDMF) in our department. There were 9 males and 2 females with an average age of 40.2±12.6 years. The mean defect size after debridement was (7.0±1.3) cm × (4.8±1.2) cm, and the average size of the flaps was (34.4±3.8) cm × (6.0±1.0) cm. The donor site was sutured directly. The postoperative blood supply in the transferred flap and function recovery of the affected limb were retrospectively collected and analyzed.ResultsSeven cases obtained direct healed without significant complications. Four cases developed postoperative infections at the distal ends of the skin flaps, and they were successfully treated by anti-infection treatment and repeated dressing changes. All patients were regularly followed up with an average of 17.3±3.8 months, satisfactory results with good flap blood supply and limb function were achieved in all patients, and no recurrence of infection was observed. ConclusionsPLDMF is a practically alternative treatment for the reconstruction of soft tissue defects combined with infection in neck and shoulder, including advantages of high survival rate, satisfactory functional recovery, and clinical practicality. However, surgical indications should be taken into account due to the inferior aesthetic appearance, especially for young female.
Reconstructing antibody dynamics to estimate the risk of influenza virus infection
Authors: Tsang Tim , Perera Ranawaka , Fang Vicky , Wong Jessica , Shiu Eunice , So Hau Chi , Ip Dennis , Peiris Malik , Leung Gabriel , Cowling Benjamin , Cauchemez Simon 
Published: October 2021

Abstract
For >70 years, a 4-fold or greater rise in antibody titer has been used to confirm influenza virus infections in paired sera, despite recognition that this heuristic can lack sensitivity. Here we analyze with a novel Bayesian model a large cohort of 2,353 individuals followed for up to 5 years in Hong Kong to characterize influenza antibody dynamics and develop an algorithm to improve the identification of influenza virus infections. After infection, we estimate that hemagglutination-inhibiting (HAI) titers were boosted by 16-fold on average and subsequently decrease by 14% per year. Greater boosting in HAI titer is observed in epidemics with a circulating strain that is different from the previous epidemic. In six epidemics, the infection risks for adults were 3%-19% while the infection risks for children were 1.6-4.4 times higher than that of younger adults. Every two-fold increase in pre-epidemic HAI titer was associated with 19%-58% protection against infection. Among the 1731 infections inferred by our model, around half were missed by the 4-fold rise criteria, suggesting that this criteria underestimates infection risks by 23-70%. The sensitivity and specificity of identifying infections for our approach are 87% (95% CrI: 85%, 89%) and 98% (95% CrI: 97%, 98%) respectively, which are higher than 82% (95% CrI: 80%, 84%) and 96% (95% CrI: 96%, 97%) for using 4-fold rise criteria. Our inferential framework clarifies the contributions of age and pre-epidemic HAI titers to characterize individual infection risk and offers an improved algorithm to identify influenza virus infections.
Lettres de Henri Roorda à Jacques Gross
Authors: Losseroy Gilles 
Published: October 2021

De la correspondance échangée entre J. Gross et H. Roorda de 1894 à 1923, seules demeurent les lettres de Roorda. Cet article en propose la synthèse, et la mise en perspective des actions et réflexions des deux correspondants au sein du mouvement anarchiste.
Keywords : Henri Roorda, Jacques Gross, anarchie, libertaire, solidarité, lectures, livres, pédagogie.
"Nomen Nominandum". La photographie comme modèle inconnu dans les carnets de voyage en Italie au début du xixe siècle
Authors: Mohs Johanne 
Published: October 2021

Pour l’histoire de l’art, les expérimentations chimiques qui ont conduit à l’invention de la photographie au début du xixe siècle sont secondaires. Ce n’est pas la fixation réussie de l’image lumineuse dans la camera obscura qui a donné naissance à ce nouveau médium, mais une nouvelle esthétique du regard qui émerge dans la peinture au début du siècle, notamment dans les croquis à l’huile de paysages. S’appuyant sur l’exemple des carnets de voyage en Italie de la même période, l’article examine dans quelle mesure cette nouvelle conception de la perspective peut également être observée dans les textes littéraires, et remet en question la datation de l’invention de la photographie à l’année 1839.
Keywords : Perspective centrale, Invention de la photographie, Carnets de voyage en Italie, Esthétique du regard, Point de vue.
Nel regno del possibile. Incontri tra fotografia e poesia nell’opera di Mario Giacomelli
Authors: Nassi Giovanni 
Published: October 2021

Lo studio prende in considerazione la pratica di Mario Giacomelli di comporre serie fotografiche in relazione a testi poetici. Vengono indagati in particolare gli intrecci semantici generati dall’incontro tra gli scatti del maestro marchigiano e i versi di Mario Luzi.
Keywords: Mario Giacomelli, Mario Luzi, La notte lava la mente, ipertesto visuale, transito.
Epistemología barroca y sentido gongorino en "Perito en lunas"
Authors: Ruiz Pérez Pedro 
Published: October 2021

Se propone la clave gongorina, con los ecos del sentido profundo de sus poemas mayores, como vía de acceso a la escritura de Perito en lunas y su cosmovisión. La epistemología de la trascendencia sostiene la clave metafórica y la visión metamórfica en una construcción que integra la aparente dispersión de las octavas, mediante la articulación de las imágenes en un universo coherente de objetos naturales y mirada poética.
Keywords: Miguel Hernández, Perito en lunas, Góngora, barroco, epistemología.
La censura y Miguel Hernández
Authors: Larrabide Aitor L. 
Published: October 2021

Este trabajo es un resumen del libro homónimo, escrito con Juan José Sánchez Balaguer y la extraordinaria participación de Nerea Pérez Rubio, mientras redactamos estas líneas (enero 2021), que será publicado a finales de 2021. La documentación procede, en su mayor parte, del Archivo General de la Administración (AGA), además del Archivo Histórico Provincial de Alicante (AHPA) y de la Biblioteca Pública del Estado «Fernando de Loazes» de Orihuela, instituciones a las que deseamos agradecer su colaboración.
Keywords: censura, Miguel Hernández, franquismo, historia del siglo XX, poesía del siglo XX.
Estimasi Kadar Air Daging Sapi Berdasarkan Luas Area Jejak Air Daging Fresh Meat Water Estimate Based On Meat Water Stain Area
Authors: Husain Fakhri , Rahmawati Elok Elita , Nugroho Widagdo Sri 
Published: October 2021

Daging sapi mengandung protein tinggi, zat besi, seng, selenium, riboflavin, vitamin B6, vitamin B12, niasin, fosfor, dan asam amino esensial yang dibutuhkan manusia. Penelitian ini bertujuan untuk mengestimasi kadar air daging sapi berdasarkan jejak air daging pada kertas. Penelitian ini dimaksudkan untuk mengantisipasi pemalsuan daging (gelonggongan). Sebanyak 10 sampel daging bagian silrloin sberat 250gram diambil dari individu berbeda yang telah dipastikan dalam kondisi sehat dan normal dan dipotong di RPH. Daging dibawa dengan kotak pendingin dari ke laboratorium. Sebanyak 100gram daging diuji proksimat dan lima (5) gram untuk uji tekan dengan berat beban sebagai perlakuan yaitu 0,5 kg dan 2 kg selama 5 menit di atas kertas di kertas saring Whatmann no 1. Luas area jejak air daging pada kertas diukur menggunakan planimeter (Planix-5, Tamaya®, Jepang). Data luas area jejak air daging hasil uji tekan dan kadar air hasil uji proksimat dianalisis regresi linier sederhana. Hasil uji proksimat menunjukkan kandungan nutrisi daging yaitu kadar air -rata 74,16±1,11%, kadar abu 0,98 ± 0,09%, kadar protein 19,38±1,47%, dan kadar lemak 3,98±2,86%. Rerata luas jejak air daging menggunakan beban 0,5 kg adalah 27,03±14,3 cm2, dan persamaan linier yang dihasilkan kadar air daging (Y)= 72,925+0,046 (P>0,05), sedangakan dengan beban 2 kg menghasilkan luas rata-rata 43,37±15,67 cm2, dan persamaan linier Y = 71,573 + 0,059X (P<0,05). Berdasarkan persamaan linier dengan beban 2 kg maka kisaran luas jejak air untuk daging normal diperoleh dari 1-143 cm2 dengan perkiraan kadar air 71,63-80,01%.
La promoción de la lectura en la vinculación universitaria
Authors: Jarvio Fernández Antonia Olivia 
Published: October 2021

Como respuesta a las exigencias globales, las instituciones de educación superior han asumido un nuevo paradigma para la educación de calidad: la formación integral de ciudadanos con competencias básicas y profesionales sustentadas en valores humanistas, en el diálogo igualitario e inclusivo; es decir, formados en programas educativos altamente vinculados a los problemas sociales. La lectura y la escritura habilitan para aprender a lo largo de la vida y para neutralizar desigualdades de diverso tipo, por lo que la formación de lectores requiere de promotores profesionales que, con los conocimientos adecuados, incidan directamente en la transformación social. Por tanto, el objetivo del presente trabajo es contribuir a la promoción de la lectura y al uso de metodologías para la evaluación y mejora de proyectos en el ámbito lector, por lo cual se analiza el impacto de un programa que hace énfasis en la vinculación universitaria y en las políticas públicas.
En concreto, se presenta una revisión sistemática de 54 proyectos de intervención en promoción de la lectura y la escritura con diversos tipos de grupos. Los proyectos se diseñaron e implementaron a partir del enfoque de aprendizaje basado en proyectos (ABP), con una perspectiva sociocultural, y en el marco de un programa de posgrado. Para la revisión se realizó una clasificación por ámbito de intervención y la discusión de resultados se alineó con una revisión de literatura. Los resultados demuestran el impacto del programa en los diversos grupos atendidos, que incluyó a diferentes ámbitos educativos, grupos sociales, algunos considerados marginales o vulnerables. Se muestra un cambio en las percepciones sobre el significado de leer y el notable desarrollo en prácticas de la lectura y la escritura, así como en el de habilidades comunicativas. Se destaca la importancia del rol del promotor de la lectura en este proceso, con lo que se reafirma la importancia de su profesionalización como agente de cambio. El conocimiento obtenido permitirá retroalimentar las políticas institucionales. En este sentido, se identificaron los avances y los retos en la promoción de la lectura tanto para la institución como para la región, sobre la importancia de fortalecer los lazos comunicantes de la universidad con los sectores sociales.
Herpes Simplex Associated Erythema Multiforme: A Case Report and Review of the Literature
Authors: Dzhelyatova G. , Miteva L. , Dourmishev L. 
Published: October 2021

Abstract
Erythema multiforme (EM) is an acute immune-mediated disease with multifactor etiology, which presents with symmetric target-like lesions on the skin. Probably the most common etiological factor of EM is viral infections, particularly herpes simplex virus (HSV). Herpes-associated erythema multiforme (HAEM) is an acute exudative dermatosis, caused mostly by HSV-1 and much rarely by HSV-2. A 44-year-old female patient with herpes associated erythema multiforme was consulted with initial appearance of typical target lesions on the dorsal surface of both hands, after long history of labial herpes episodes. The diagnostic algorithm included routine laboratory tests, histological examination and serologic test for HSV-1 and 2. Our first choice of treatment was acyclovir 5 x 200 mg/24 h and dexamethasone 4 mg/24 h, however due to increased anxiety and tachycardia reported by patient the corticosteroid therapy was discontinued and promethazine was initiated. The patient responded well to the therapeutic regimen and at the follow-up visit was in clinical remission. In conclusion, the diagnosis of HAEM is mainly clinical, when the patient develops target lesions and coexisting HSV infection is detected.