bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of the CMS-EXO-19-002 search in the MadAnalysis 5 framework (physics beyond the Standard Model with multilepton final states; 137 fb−1)
Authors: Conte Eric , Ducrocq Robin 
Published: January 2021

In this paper, we present the MadAnalysis 5 implementation of the CMS-EXO-19-002 analysis, probing an excess of events featuring multiple charged leptons in LHC proton–proton collisions at [Formula: see text]. The original analysis is based on data acquired by the CMS detector during the 2016–2018 campaign, which corresponds to an integrated luminosity of 137 fb[Formula: see text]. Data have been tested against hypothetical extensions of the Standard Model where additional leptons can stem from new heavy fermion decays or from new light scalar/pseudoscalar decays. The CMS selection has been fully implemented in the MadAnalysis 5 platform and successfully validated by reproducing official results in the form of signal distributions at the end of the selection.
Религията в теоретичното поле на съвременните балкански изследователи (контекстът на разпадането на бивша Югославия)
Authors: Богомилова [Bogomilova] Нонка [Nonka] 
Published: January 2021

Religion Within the Theoretical Field of Contemporary Balkan Scholars (In the Context of the Collapse of the Former Yugoslavia)This study aims to describe and analyse the main topics and trends in the study of religion in contemporary Balkan countries. It pays special attention to the contemporary sociology of religion in the former Yugoslavian countries: Croatia, Slovenia, Serbia, North Macedonia, Montenegro, and Bosnia and Herzegovina. Various theoretical approaches are presented that are used in order to understand the dynamic processes that have developed in the contemporary religious situation. The topics and discussions at various seminar sessions, conferences, and workshops are analyzed as theoretical reflection on religion and as an ethical attitude towards intellectual and cultural developments and processes accompanying social change, the war in former Yugoslavia, and the post-communist transformations in the end of 20th and the beginning of 21st century. The relevant publications and organizational forms are outlined. The mutual collaboration among Balkan scholars and the forms of international relations developed in the Balkans within the framework of religious studies are described. Religia w polu teoretycznym współczesnych badaczy bałkańskich (w kontekście rozpadu byłej Jugosławii)Celem artykułu jest opis i analiza głównych tematów i trendów we współczesnej nauce o religii na Bałkanach. Autorka skupia się na współczesnej socjologii religii w krajach byłej Jugosławii (Chorwacji, Słowenii, Serbii, Macedonii Północnej, Czarnogórze, Bośni i Hercegowinie) i wskazuje na różne podejścia teoretyczne, jakie stosowane są do zrozumienia dynamicznych procesów, którym podlega obecnie sytuacja wyznaniowa. Tematy i dyskusje na różnych sesjach seminaryjnych, konferencjach i warsztatach są tu interpretowane jako teoretyczna refleksja nad religią oraz jako wyraz etycznego podejścia do procesów intelektualnych i kulturowych towarzyszącym zmianom społecznym, wojnie w byłej Jugosławii i transformacjom postkomunistycznym na przełomie XX i XXI wieku. W artykule przedstawione zostały istotne publikacje i formy organizacyjne. Opisana została współpraca bałkańskich uczonych i formy stosunków międzynarodowych, jakie rozwinęły się na tym obszarze w ramach studiów religijnych.
Krzątactwo i droga pielgrzyma we wspomnieniach Michaiła Madżarowa
Authors: Szwat-Gyłybowa Grażyna 
Published: January 2021

Bustling About and the Pilgrim’s Way in Mihail Madjarov’s MemoirThis article is devoted to reflection on Mihail Madjarov’s memoir prose, На Божи Гроб преди шестдесет години и днес (спомени, пътни бележки и впечатления) (To the tomb of Jesus sixty years ago and today (memoirs, travel notes and impressions), 1929), which is primarily dedicated to the author’s childhood pilgrimage to Jerusalem. In the article, I use the philosophical category of ‘bustling about’ (in Polish: krzątactwo), which was proposed by Jolanta Brach-Czaina, as a category that supports analysis of the strategies, described by Madjarov, of pilgrims experiencing everyday life in the three phases of their peregrination (according to Victor Turner’s classification). The analysis of the material takes into consideration the Ottoman historical context in connection with research on the testimonies of nineteenth-century Bulgarian hadjis. Krzątactwo i droga pielgrzyma we wspomnieniach Michaiła MadżarowaArtykuł poświęcony jest refleksji nad prozą wspomnieniową Michaiła Madżarowa На Божи Гроб преди шестдесет години и днес (спомени, пътни бележки и впечатления) (Do Grobu Jezusa przed sześćdziesięcioma laty i dziś (wspomnienia, notatki z podróży i wrażenia), 1929), poświęconą głównie odbytej przez autora w dzieciństwie pielgrzymce do Jerozolimy. W artykule posługuję się zaproponowaną przez Jolantę Brach-Czainę filozoficzną kategorią krzątactwa jako kategorią wspomagającą analizę opisanych przez autora strategii doświadczania codzienności przez pielgrzymów w trzech fazach ich peregrynacji (według klasyfikacji Turnera). Materiał analizowany jest z uwzględnieniem osmańskiego kontekstu historycznego, w powiązaniu z badaniami nad świadectwami bułgarskich dziewiętnastowiecznych hadżijów.
Křesťanský učitel v sekularizované škole České republiky
Authors: Podzimek Michal 
Published: January 2021

Christian Teachers in Secularized Schools in the Czech RepublicThis article presents the specific situation of Christian teachers working in schools in North Bohemia. This region underwent forced secularization during the communist period and Christians became a marginal social group. Since the fall of communism, teachers have been bound by the official framework of objective science, ideological neutrality, and pluralism of opinion. The aforementioned values have been incorporated into the curriculum of the educational system in the Czech Republic. On the other hand, Christian teachers are bound in their conscience by requirements of ecclesiastical orthodoxy, which is partly based on pre-modern dogmatic positions. Chrześcijański nauczyciel w zsekularyzowanej szkole w CzechachArtykuł przedstawia specyficzną sytuację chrześcijańskich nauczycieli pracujących w szkołach w północnych Czechach. Region ten podlegał przymusowej sekularyzacji w czasach reżimu komunistycznego, a chrześcijanie stali się marginalną grupą społeczną. Po upadku komunizmu nauczyciele są związani oficjalnymi ramami obiektywnej nauki, ideologicznej neutralności i pluralizmu opinii. Z jednej strony wymienione wyżej wartości są zagwarantowane w systemie edukacji w Czechach. Z drugiej strony chrześcijańscy nauczyciele są związani w swoim sumieniu wymogami kościelnej ortodoksji, która częściowo opiera się na przednowoczesnych zasadach dogmatycznych.
Transient Climate Response to Arctic Sea Ice Loss with Two Ice-Constraining Methods
Authors: Simon Amélie , Gastineau Guillaume , Frankignoul Claude , Rousset Clément , Codron Francis 
Published: January 2021

AbstractThe impact of Arctic sea ice loss on the ocean and atmosphere is investigated focusing on a gradual reduction of Arctic sea ice by 20% of the annual mean, occurring within 30 years, starting from present-day conditions. Two ice-constraining methods are explored to melt Arctic sea ice in a coupled climate model, while keeping present-day conditions for external forcing. The first method uses a reduction of sea ice albedo, which modifies the incoming surface shortwave radiation. The second method uses a reduction of thermal conductivity, which changes the heat conduction flux inside ice. Reduced thermal conductivity inhibits oceanic cooling in winter and sea ice basal growth, reducing the seasonality of sea ice thickness. For similar Arctic sea ice area loss, decreasing the albedo induces larger Arctic warming than reducing the conductivity, especially in spring. Both ice-constraining methods produce similar climate impacts, but with smaller anomalies when reducing the conductivity. In the Arctic, the sea ice loss leads to an increase of the North Atlantic water inflow in the Barents Sea and eastern Arctic, while the salinity decreases and the gyre intensifies in the Beaufort Sea. In the North Atlantic, the subtropical gyre shifts southward and the Atlantic meridional overturning circulation weakens. A dipole of sea level pressure anomalies sets up in winter over northern Siberia and the North Atlantic, which resembles the negative phase of the North Atlantic Oscillation. In the tropics, the Atlantic intertropical convergence zone shifts southward as the South Atlantic Ocean warms. In addition, Walker circulation reorganizes and the southeastern Pacific Ocean cools.
Improvement of Solid Precipitation Measurements Using a Hotplate Precipitation Gauge
Authors: Thériault Julie M. , Leroux Nicolas R. , Rasmussen Roy M. 
Published: January 2021

AbstractAccurate snowfall measurement is challenging because it depends on the precipitation gauge used, meteorological conditions, and the precipitation microphysics. Upstream of weighing gauges, the flow field is disturbed by the gauge and any shielding used usually creates an updraft, which deflects solid precipitation from falling in the gauge, resulting in significant undercatch. Wind shields are often used with weighing gauges to reduce this updraft, and transfer functions are required to adjust the snowfall measurements to consider gauge undercatch. Using these functions reduces the bias in precipitation measurement but not the root-mean-square error (RMSE). In this study, the accuracy of the Hotplate precipitation gauge was compared to standard unshielded and shielded weighing gauges collected during the WMO Solid Precipitation Intercomparison Experiment program. The analysis performed in this study shows that the Hotplate precipitation gauge bias after wind correction is near zero and similar to wind corrected weighing gauges. The RMSE of the Hotplate precipitation gauge measurements is lower than weighing gauges (with or without an Alter shield) for wind speeds up to 5 m s−1, the wind speed limit at which sufficient data were available. This study shows that the Hotplate precipitation gauge measurement has a low bias and RMSE due to its aerodynamic shape, making its performance mostly independent of the type of solid precipitation.
Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt
Authors: Flukes Stephanie , Long Sallie , Lohia Shivangi , Barker Christopher A. , Dunn Lara A. , Cracchiolo Jennifer , Ganly Ian , Patel Snehal , Cohen Marc A. 
Published: January 2021

ObjectiveTo characterize a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic outcomes following definitive treatment.Study DesignRetrospective chart review.SettingNational Cancer Institute–designated Comprehensive Cancer Center.MethodsWe conducted a retrospective chart review of patients with cutaneous squamous cell carcinoma with metastases to intraparotid lymph nodes who underwent parotidectomy between 1993 and 2020. Baseline patient and tumor characteristics were assessed. Regional control, disease‐specific survival, and overall survival were estimated using Kaplan‐Meier method. Multivariate analysis was used to determine the relationship between adverse pathological features and survival.ResultsA total of 122 patients were included. The median age was 76, 84.4% of patients were male, and 17.2% were immunosuppressed. Regional control, disease‐specific survival, and overall survival were 68.5%, 70.7%, and 59.4% at 5 years, respectively. Perineural and lymphovascular invasion were predictive of worse disease‐specific survival. Extracapsular spread was observed in 90.2% of patients and was not a significant predictor of outcome.ConclusionsWe found the demographics and oncologic outcomes of our cohort in the Northeast United States to be comparable with those previously reported in Australia and the Sun Belt of the United States. We noted a high rate of extracapsular spread but did not find it to be a significant predictor of recurrence or survival. Future efforts should address the impact of extracapsular spread on prognosis and adjuvant treatment decisions.
Concizumab: a novel anti-TFPI therapeutic for hemophilia
Authors: Shapiro Amy D. 
Published: January 2021

Abstract
Concizumab is a novel subcutaneous prophylactic therapy for hemophilia. It is a hemostatic rebalancing agent that binds to the Kunitz-2 domain of tissue factor pathway inhibitor (TFPI), one of the molecules that contributes to downregulation of coagulation thereby preventing TFPI from binding to and blocking the factor Xa (FXa) active site. When the TFPI inhibitory activity is decreased, sufficient FXa is produced by the FVIIa-tissue factor complex to achieve hemostasis. On the basis of this mechanism of action, concizumab is expected to be equally effective in hemophilia A and B, regardless of inhibitor status. Moreover, the concizumab mechanism of action does not interfere with the regulation of coagulation downstream of TFPI. Results from 2 phase 2 trials in patients with hemophilia A or B with and without inhibitors demonstrated that concizumab had a favorable safety profile, with no deaths, no thromboembolic events, and no adverse events leading to withdrawal. Clinical proof of concept in prevention of bleeding episodes was confirmed in both concizumab phase 2 trials across all hemophilia subtypes assessed, with a statistically significant and clinically relevant reduction in annualized bleeding rates observed in inhibitor patients compared to those who received on-demand treatment. On the basis of phase 2 results, the US Food and Drug Administration granted concizumab Breakthrough Therapy designation for hemophilia B with inhibitor patients, a rare and vulnerable patient subgroup that currently has the highest unmet medical need. In the ongoing concizumab phase 3 trials, an optimized dosing regimen will be administered in patients with hemophilia A or B with and without inhibitors.
ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
Authors: James Paula D. , Connell Nathan T. , Ameer Barbara , Di Paola Jorge , Eikenboom Jeroen , Giraud Nicolas , Haberichter Sandra , Jacobs-Pratt Vicki , Konkle Barbara , McLintock Claire , McRae Simon , R. Montgomery Robert , O’Donnell James S. , Scappe Nikole , Sidonio Robert , Flood Veronica H. , Husainat Nedaa , Kalot Mohamad A. , Mustafa Reem A. 
Published: January 2021

Background:
von Willebrand disease (VWD) is the most common inherited bleeding disorder known in humans. Accurate and timely diagnosis presents numerous challenges.

Objective:
These evidence-based guidelines of the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF), and the World Federation of Hemophilia (WFH) are intended to support patients, clinicians, and other health care professionals in their decisions about VWD diagnosis.

Methods:
ASH, ISTH, NHF, and WFH established a multidisciplinary guideline panel that included 4 patient representatives and was balanced to minimize potential bias from conflicts of interest. The Outcomes and Implementation Research Unit at the University of Kansas Medical Center (KUMC) supported the guideline-development process, including performing or updating systematic evidence reviews up to 8 January 2020. The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including GRADE Evidence-to-Decision frameworks, to assess evidence and make recommendations, which were subsequently subject to public comment.

Results:
The panel agreed on 11 recommendations.

Conclusions:
Key recommendations of these guidelines include the role of bleeding-assessment tools in the assessment of patients suspected of VWD, diagnostic assays and laboratory cutoffs for type 1 and type 2 VWD, how to approach a type 1 VWD patient with normalized levels over time, and the role of genetic testing vs phenotypic assays for types 2B and 2N. Future critical research priorities are also identified.
Under the influence of regulations: spatio-temporal trends of the UV filter 2-Ethylhexyl-4-methoxycinnamate (EHMC) in German rivers
Authors: Nagorka Regine , Duffek Anja 
Published: January 2021

Abstract
Background
Globally, 2-Ethylhexyl-4-methoxycinnamate (EHMC) is one of the most commonly used UV filters in sunscreen and personal care products. Due to its widespread usage, the occurrence of EHMC in the aquatic environment has frequently been documented. In the EU, EHMC is listed under the European Community Rolling Action Plan (CoRAP) as suspected to be persistent, bioaccumulative, and toxic (PBT) and as a potential endocrine disruptor. It was included in the first watch list under the Water Framework Directive (WFD) referring to a sediment PNEC of 200 µg/kg dry weight (dw). In the light of the ongoing substance evaluation to refine the environmental risk assessment, the objective of this study was to obtain spatio-temporal trends for EHMC in freshwater.
We analyzed samples of suspended particulate matter (SPM) retrieved from the German environmental specimen bank (ESB). The samples covered 13 sampling sites from major German rivers, including Rhine, Elbe, and Danube, and have been collected since mid-2000s.

Results
Our results show decreasing concentrations of EHMC in annual SPM samples during the studied period. In the mid-2000s, the levels for EHMC ranged between 3.3 and 72 ng/g dw. The highest burden could be found in the Rhine tributary Saar. In 2017, we observed a maximum concentration ten times lower (7.9 ng/g dw in samples from the Saar). In 62% of all samples taken in 2017, concentrations were even below the limit of quantification (LOQ) of 2.7 ng/g dw.

Conclusions
The results indicate a general declining discharge of EHMC into German rivers within the last 15 years and correspond to the market data. Although the measured levels are below the predicted no-effect level (PNEC) in sediment, further research should identify local and seasonal level of exposure, e.g., at highly frequented bathing waters especially in lakes. In addition, possible substitutes as well as their potentially synergistic effects together with other UV filters should be investigated.
PacBio full-length transcriptome of wild apple (Malus sieversii) provides insights into canker disease dynamic response
Authors: Liu Xiaojie , Li Xiaoshuang , Wen Xuejing , Zhang Yan , Ding Yu , Zhang Yiheng , Gao Bei , Zhang Daoyuan 
Published: January 2021

Abstract
Background
Valsa canker is a serious disease in the stem of Malus sieversii, caused by Valsa mali. However, little is known about the global response mechanism in M. sieversii to V. mali infection.

Results
Phytohormone jasmonic acid (JA) and salicylic acid (SA) profiles and transcriptome analysis were used to elaborate on the dynamic response mechanism. We determined that the JA was initially produced to respond to the necrotrophic pathogen V. mali infection at the early response stage, then get synergistically transduced with SA to respond at the late response stage. Furthermore, we adopted Pacific Biosciences (PacBio) full-length sequencing to identify differentially expressed transcripts (DETs) during the canker response stage. We obtained 52,538 full-length transcripts, of which 8139 were DETs. Total 1336 lncRNAs, 23,737 alternative polyadenylation (APA) sites and 3780 putative transcription factors (TFs) were identified. Additionally, functional annotation analysis of DETs indicated that the wild apple response to the infection of V. mali involves plant-pathogen interaction, plant hormone signal transduction, flavonoid biosynthesis, and phenylpropanoid biosynthesis. The co-expression network of the differentially expressed TFs revealed 264 candidate TF transcripts. Among these candidates, the WRKY family was the most abundant. The MsWRKY7 and MsWRKY33 were highly correlated at the early response stage, and MsWRKY6, MsWRKY7, MsWRKY19, MsWRKY33, MsWRKY40, MsWRKY45, MsWRKY51, MsWRKY61, MsWRKY75 were highly correlated at the late stage.

Conclusions
The full-length transcriptomic analysis revealed a series of immune responsive events in M. sieversii in response to V. mali infection. The phytohormone signal pathway regulatory played an important role in the response stage. Additionally, the enriched disease resistance pathways and differentially expressed TFs dynamics collectively contributed to the immune response. This study provides valuable insights into a dynamic response in M. sieversii upon the necrotrophic pathogen V. mali infection, facilitates understanding of response mechanisms to canker disease for apple, and provides supports in the identification of potential resistance genes in M. sieversii.
Sleep disturbances in obsessive-compulsive disorder: influence of depression symptoms and trait anxiety
Authors: Segalàs Cinto , Labad Javier , Salvat-Pujol Neus , Real Eva , Alonso Pino , Bertolín Sara , Jiménez-Murcia Susana , Soriano-Mas Carles , Monasterio Carmen , Menchón José M. , Soria Virginia 
Published: January 2021

Abstract
Background
Sleep disturbances have been reported in obsessive-compulsive disorder (OCD) patients, with heterogeneous results. The aim of our study was to assess sleep function in OCD and to investigate the relationship between sleep and the severity of obsessive-compulsive (OC) symptoms, depressive symptoms and trait anxiety.

Methods
Sleep quality was measured in 61 OCD patients and 100 healthy controls (HCs) using the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regression was conducted to explore the association between sleep and psychopathological measures; a mediation analysis was also performed.

Results
OCD patients showed poor sleep quality and more sleep disturbances compared to HCs. The severity of depression, trait anxiety and OC symptomatology were correlated with poor sleep quality. Multiple linear regression analyses controlling for potential confounders revealed that the severity of depression and trait anxiety were independently related to poor sleep quality in OCD. A mediation analysis showed that both the severity of trait anxiety and depression mediate the relationship between the severity of OC symptoms and poor sleep quality among patients with OCD.

Conclusions
Our findings support the existence of sleep disturbances in OCD. Trait anxiety and depression play a key role in sleep quality among OCD patients.