bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Ischemic Conditioning With Exercise (RICE)—Rehabilitative Strategy in Patients With Acute Ischemic Stroke: Rationale, Design, and Protocol for a Randomized Controlled Study
Authors: Han Zhenzhen , Zhao Wenbo , Lee Hangil , Wills Melissa , Tong Yanna , Cheng Zhe , Dai Qingqing , Li Xiaohua , Wang Qingzhu , Geng Xiaokun , Ji Xunming , Ding Yuchuan 
Published: May 2021

Objective: Exercise rehabilitation is an effective therapy in reducing the disability rate after stroke and should be carried out as early as possible. However, very early rehabilitation exercise exacerbates brain injury and is difficult to conduct in stroke patients due to their weakened and potentially disabled state. It is valuable to explore additional early rehabilitation strategies. Remote Ischemic Conditioning (RIC) is a novel therapy designed to protect vital organs from severe lethal ischemic injury by transient sublethal blood flow to non-vital organs, including the distal limbs, in order to induce endogenous protection. RIC has previously been conducted post-stroke for neuroprotection. However, whether combined early RIC and exercise (RICE) therapy enhances stroke rehabilitation remains to be determined.Methods: This is a single-center, double-blinded, randomized controlled trial that will enroll acute ischemic stroke patients within 24 h of symptom onset or symptom exacerbation. All enrolled patients will be randomly assigned to either the RICE group (exercise with RIC) or the control group (exercise with sham RIC) at a ratio of 1:1, with 20 patients in each group. Both groups will receive RIC or sham RIC within 24 h after stroke onset or symptom exacerbation, once a day, for 14 days. All patients will begin exercise training on the fourth day, twice a day, for 11 days. Their neurological function [Modified Rankin Scale (mRS) score, National Institutes of Health Stroke Scale (NIHSS) score, Barthel Index, and walking ability], infarct volume (nuclear magnetic resonance, MRI), and adverse events will be evaluated at different time points in their post-stroke care.Results: The primary outcome is safety, measured by the incidence of any serious RICE-related adverse events and decreased adverse events during hospitalization. The secondary outcome is a favorable prognosis within 90 days (mRS score &lt; 2), determined by improvements in the mRS score, NIHSS score, Barthel Index, walking ability after 90 days, and infarct volume after 12 ± 2 days.Conclusion: This study is a prospective randomized controlled trial to determine the rehabilitative effect of early RIC followed by exercise on patients with acute ischemic stroke.Trial Registration:www.chictr.org.cn, identifier: ChiCTR2000041042
Cost-Effectiveness of Anti-Epidermal Growth Factor Receptor Therapy Versus Bevacizumab in KRAS Wild-Type (WT), Pan-RAS WT, and Pan-RAS WT Left-Sided Metastatic Colorectal Cancer
Authors: Lee Shing Fung , Choi Horace C. W. , Chan Sik Kwan , Lam Ka On , Lee Victor H. F. , Wong Irene O. L. , Chiang Chi Leung 
Published: May 2021

ObjectivesWe aimed to compare the economic value of chemotherapy plus anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibody (mAb) against chemotherapy with bevacizumab (Bev, an anti-vascular endothelial growth factor mAb) as first-line treatment in KRAS wild-type (WT), pan-RAS WT and pan-RAS WT left-sided metastatic colorectal cancer (mCRC) patients from the Hong Kong societal perspective.Materials and MethodsWe developed Markov models and 10-year horizon to estimate costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER) of chemotherapy plus anti-EGFR therapy against chemotherapy plus Bev in KRAS WT, pan-RAS WT, and pan-RAS WT left-sided mCRC. We considered two times of the local gross domestic product per capita (GDPpc) as the willingness-to-pay (WTP) threshold (2× GDPpc; US$97,832).ResultsAdding anti-EGFR mAb to chemotherapy provides additional 0.24 (95% confidence interval [CI] 0.19–0.29), 0.32 (95% CI 0.27–0.37), and 0.57 (95% CI 0.49–0.63) QALY compared to adding Bev in KRAS WT, pan-RAS WT, and left-sided pan-RAS WT mCRC populations respectively. The corresponding ICER is US$106,847 (95% CI 87,806–134,523), US$88,565 (95% CI 75,678–105,871), US$76,537 (95% CI 67,794–87,917) per QALY gained, respectively.ConclusionsAnti-EGFR therapy is more cost-effective than Bev as a first-line targeted therapy in left-sided pan-RAS WT and pan-RAS WT, with ICER &lt;US$100,000/QALY, compared to KRAS WT mCRC population.
Calcitonin Gene–Related Peptide Monoclonal Antibody Versus Botulinum Toxin for the Preventive Treatment of Chronic Migraine: Evidence From Indirect Treatment Comparison
Authors: Lu Jiajie , Zhang Quanquan , Guo Xiaoning , Liu Wei , Xu Chunyang , Hu Xiaowei , Ni Jianqiang , Lu Haifeng , Zhao Hongru 
Published: May 2021

Background: The previously approved botulinum toxin and nowadays promising calcitonin gene-related peptide (CGRP) monoclonal antibody have shown efficacy for preventing chronic migraine (CM). However, there is no direct evidence for their relative effectiveness and safety. In this study, we conducted an indirect treatment comparison to compare the efficacy and safety of CGRP monoclonal antibody with botulinum toxin for the preventive treatment of chronic migraine.Methods: Up to August 31, 2020, we systematically searched PubMed, Embase, and Cochrane Library Central Register of Controlled Trials (Central). Weighted mean difference (WMD) and relative risk (RR) were used to evaluate clinical outcomes. Indirect treatment comparison (ITC) software was used to conduct indirect treatment comparison.Results: Ten studies were pooled with 6,325 patients in our meta-analysis. Both botulinum toxin and CGRP monoclonal antibody demonstrated favorable efficacy in the change of migraine days, headache days, HIT-6 score, and 50% migraine responder rate compared with placebo. In indirect treatment comparison, CGRP monoclonal antibody was superior to botulinum toxin in the frequency of acute analgesics intake (WMD = −1.31, 95% CI: −3.394 to 0.774, p = 0.02113), the rate of treatment-related adverse events (AEs) (RR = 0.664, 95% CI: 0.469 to 0.939, p = 0.04047), and the rate of treatment-related serious adverse events (RR = 0.505, 95% CI: 0.005 to 46.98, p &lt; 0.001).Conclusion: For chronic migraine patients, CGRP monoclonal antibody was slightly better than botulinum toxin in terms of efficacy and safety. In the future, head-to-head trials would be better to evaluate the efficacy and safety between different medications in the prevention of chronic migraine.
Pulmonary Arterial Remodeling Is Related to the Risk Stratification and Right Ventricular-Pulmonary Arterial Coupling in Patients With Pulmonary Arterial Hypertension
Authors: Grignola Juan C. , Domingo Enric , López-Meseguer Manuel , Trujillo Pedro , Bravo Carlos , Pérez-Hoyos Santiago , Roman Antonio 
Published: May 2021

BackgroundPulmonary arterial (PA) stiffness has an essential contribution to the right ventricular (RV) failure pathogenesis. A comprehensive and multiparameter risk assessment allows predicting mortality and guiding treatment decisions in PA hypertension (PAH). We characterize PA remodeling with intravascular ultrasound (IVUS) in prevalent and stable patients with PAH according to the ESC/ERS risk table and analyze the RV-PA coupling consequences.MethodsTen control subjects and 20 prevalent PAH adult patients underwent right heart catheterization (RHC) with simultaneous IVUS study. We estimated cardiac index (CI), pulmonary vascular resistance, and compliance (PVR, PAC) by standard formulas. From IVUS and RHC data, PA diameter, wall thickness/luminal diameter ratio, and indexes of stiffness (pulsatility, compliance, distensibility, incremental elastic modulus - Einc-, and the stiffness index β) were measured. We evaluated RV-PA coupling by the ratio of tricuspid annular plane systolic excursion to systolic pulmonary arterial pressure (TAPSE/sPAP). The individual average risk was calculated by assigning a score of 1 (low-risk -LR-), 2 (intermediate-risk -IR-), and 3 (high-risk -HR-) for each of seven variables (functional class, six-minute walking test, brain natriuretic peptide, right atrial area and pressure, CI, and PA oxygen saturation) and rounding the average value to the nearest integer.ResultsAll PA segments interrogated showed increased vessel diameter, wall cross-sectional area (WCSA), and stiffness in patients with PAH compared to control subjects. 45% corresponded to LR, and 55% corresponded to IR PAH patients. The different measurements of PA stiffness showed significant correlations with TAPSE/sPAP (r = 0.6 to 0.76) in PAH patients. The IR group had higher PA stiffness and lower relative WCSA than LR patients (P &lt; 0.05), and it is associated with a lower PAC and TAPSE/sPAP (P &lt; 0.05).ConclusionIn prevalent PAH patients, the severity of proximal PA remodeling is related to the risk stratification and associated with PAC and RV-PA coupling impairment beyond the indirect effect of the mean PA pressure. The concomitant assessment of IVUS and hemodynamic parameters at diagnosis and follow-up of PAH patients could be a feasible and safe tool for risk stratification and treatment response of the PA vasculopathy during serial hemodynamic measurements.
End of Life Intervention Program During COVID-19 in Vall d'Hebron University Hospital
Authors: Beneria Anna , Castell-Panisello Eudald , Sorribes-Puertas Marta , Forner-Puntonet Mireia , Serrat Laia , García-González Sara , Garriga Maria , Simon Carmen , Raya Consuelo , Montes Maria José , Rios Giuliana , Bosch Rosa , Citoler Bárbara , Closa Helena , Corrales Montserrat , Daigre Constanza , Delgado Mercedes , Dip Maria Emilia , Estelrich Neus , Jacas Carlos , Lara Benjamin , Lugo-Marin Jorge , Nieto-Fernández Zaira , Regales Christina , Ibáñez Pol , Blanco Eunice , Ramos-Quiroga Josep Antoni 
Published: May 2021

Introduction: The coronavirus disease 19 (COVID-19) and its consequences have placed our societies and healthcare systems under pressure. Also, a major impact on the individual and societal experience of death, dying, and bereavement has been observed. Factors such as social distancing, unexpected death or not being able to say goodbye, which might predict Prolonged Grief Disorder (PGD), are taking place. Moreover, hospitals have become a habitual place for End of Life (EOL) situations but not in the usual conditions because, for example, mitigation measures prevent families from being together with hospitalized relatives. Therefore, we implemented an EOL program with a multidisciplinary team involving health social workers (HSW) and clinical psychologists (CP) in coordination with the medical teams and nursing staff.Objectives: We aim to describe an EOL intervention program implemented during COVID-19 in the Vall d'Hebron University Hospital (HUVH). We present its structure, circuit, and functions. Descriptive analyses of the sample and the interventions that required psychological and social attention are reported.Material and methods: The total sample consists of 359 relatives of 219 EOL patients. Inclusion criteria were families cared for during the COVID-19 pandemic with family patients admitted to the HUVH in an EOL situation regardless of whether or not the patient was diagnosed with COVID-19.Results: Our program is based on family EOL care perceptions and the COVID-19 context features that hinder EOL situations. The program attended 219 families, of which 55.3% were COVID-19 patients and 44.7% had other pathologies. The EOL intervention program was activated in most of the EOL situations, specifically, in 85% of cases, and 78% of relatives were able to come and say goodbye to their loved ones. An emotional impact on the EOL team was reported. It is necessary to dignify the EOL situation in the COVID-19 pandemic, and appropriate psychosocial attention is needed to try to minimize future complications in grief processes and mitigate PGD.
EGFR Alterations Influence the Cetuximab Treatment Response and c-MET Tyrosine-Kinase Inhibitor Sensitivity in Experimental Head and Neck Squamous Cell Carcinomas
Authors: Nelhűbel Györgyi A. , Cserepes Mihály , Szabó Balázs , Türk Dóra , Kárpáti Adél , Kenessey István , Rásó Erzsébet , Barbai Tamás , Hegedűs Zita , László Viktória , Szokol Bálint , Dobos Judit , Őrfi László , Tóvári József 
Published: May 2021

Background: Anti-EGFR antibody therapy is still one of the clinical choices in head and neck squamous cell carcinoma (HNSCC) patients, but the emergence of cetuximab resistance questioned its effectiveness and reduced its applicability. Although several possible reasons of resistance against the antibody treatment and alternative therapeutic proposals have been described (EGFR alterations, activation of other signaling pathways), there is no method to predict the effectiveness of anti-EGFR antibody treatments and to suggest novel therapeutics. Our study investigated the effect of EGFR R521K alteration on efficiency of cetuximab therapy of HNSCC cell lines and tried to find alternative therapeutic approaches against the resistant cells.Methods: After genetic characterization of HNSCC cells, we chose one wild type and one R521K+ cell line for in vitro proliferation and apoptosis tests, and in vivo animal models using different therapeutic agents.Results: Although the cetuximab treatment affected EGFR signalization in both cells, it did not alter in vitro cell proliferation or apoptosis. In vivo cetuximab therapy was also ineffective on R521K harboring tumor xenografts, while blocked the tumor growth of EGFR-wild type xenografts. Interestingly, the cetuximab-resistant R521K tumors were successfully treated with c-MET tyrosine kinase inhibitor SU11274.Conclusion: Our results suggest that HNSCC cell line expressing the R521K mutant form of EGFR does not respond well to cetuximab treatment in vitro or in vivo, but hopefully might be targeted by c-MET tyrosine kinase inhibitor treatment.
La Búsqueda de Soluciones Creativas desde la Práctica Laboral en la Carrera Educación Preescolar
Authors: Rodríguez Álvarez Maidelys , Vázquez Vázquez Juana María , Del Cristo Sosa Yudith 
Published: May 2021

La solución de determinadas tareas en la práctica constituye el punto de partida para la Disciplina Principal Integradora, la cual se apoya en los aportes de las restantes disciplinas de la carrera y las asume en su integración para dar respuesta a las exigencias del quehacer profesional para la Educación Preescolar, asegura el dominio de los modos de actuación esenciales, sin embargo, se hace necesario potenciar el desarrollo de la creatividad en situaciones que se presentan en la práctica educativa. El presente trabajo forma parte de una investigación que se realiza en la universidad, se hace referencia a los fundamentos teóricos y metodológicos acerca del modo de actuación creativo de los profesionales en formación desde el proceso de enseñanza aprendizaje de la Disciplina Principal Integradora.
Orientaciones Educativas para Promover el Crecimiento Personal en los Jóvenes. Una Propuesta para Educadores
Authors: Cubela González Juana Maria 
Published: May 2021

Los educadores, con responsabilidad de influir positivamente en la formación integral de la juventud, tienen ante sí la compleja tarea de contribuir al desarrollo y crecimiento personal de los jóvenes, han de tener a su alcance alternativas que le permitan conducir, con intencionalidad, esta complicada responsabilidad. Es propósito de la autora sugerir vías, acciones de orientación educativa, procedimientos que contribuyan a potenciar en la juventud la capacidad de asumir su propio crecimiento personal, con una mejor comprensión de sí mismo en armonía con el grupo. Para lograr este propósito se aplicaron diferentes métodos como: Análisis – síntesis, inducción - deducción, sistematización de opiniones y valoraciones, entrevistas y triangulación de fuentes y métodos.
KECERNAAN BAHAN ORGANIK, SERAT KASAR DAN LEMAK KASAR PAKAN AYAM PEDAGING YANG DIBERI TEPUNG LIMBAH LABU KUNING (Cucurbita moschata)
Authors: Moningkey Andre F. , Wolayan Fenny R. , Rahasia Cathrien A. , Regar Mursye N. 
Published: May 2021

DIGESTIBILITY OF THE ORGANIC MATTER, CRUDE FIBER AND CRUDE FAT IN BROILERS RATION CONTAINING PUMPKIN WASTE MEAL (Cucurbita moschata). A research was done to determine the digestibility values of feed in term of organic matter, crude fiber and crude fat containing pumpkin waste meal (PWM) fed to broilers. The research was conducted by involving 20 unsexed broilers, strain CP 707 at 5 weeks old with an average body weight of 1073 g. Experiment design of the Completely Randomized Designed (CRD) was applied with 4 treatments and 5 replications at each treatment. Honestly significant difference test (HSD) was used to define higher significant effects of the treatments. The treatments consist of 100% basal ration (BR) + 0% PWM (R0), 95% BR + 5% PWM (R1), 90% BR + 10% PWM (R2) and 85% BR + 15% PWM (R3). Results showed that digestibility of crude fiber was significantly affected by treatments (P<0.01), but digestibility values of organic matter and crude fat were not influenced by these treatments. The statistical test showed that the crude fiber digestibility of R0 (56.92%) was lower than those of R1 (63.10%), R2 (67.71%) and R3 (66.30%). Furthermore, there was no difference among digestibility values of R1, R2 and R3. Based on this research, it can be concluded that pumpkin waste meal could be utilized to replace some parts up to 15% in ration of broilers. Keyword: Pumpkin waste meal, digestibility, broiler
PENGARUH PENGGUNAAN MINYAK KELAPA DALAM RANSUM TERHADAP BOBOT BADAN AKHIR, BOBOT DAN PERSENTASE KARKAS, SERTA PERSENTASE LEMAK ABDOMINAL PADA AYAM BURAS SUPER
Authors: Nelwan Yosua , Leke Jein R. , Sompie Florencia N. , Laihad Jacqueline T. 
Published: May 2021

UTILIZATION EFFECT OF COCONUT OIL IN RATION ON BODY WEIGHT, PERCENTAGES OF CARCASS AND ABDOMINAL FAT IN SUPER NATIVE HENS. This study was conducted to evaluate utilization effect of coconut oil in ration on body weight, percentages of carcass and abdominal fat in super native hens. This study was involving hundred unsexed super native hens at ages of eight weeks with the average initial body weight of 862.24 g ± 44.13 g. The treatments were ration without coconut oil (CO) utilization (R0), ration of 99.5% basal added with 0.5% CO (R1), ration of 99% basal added with 1% CO (R2), ration of 98.5% basal added with 1.5% CO (R3), and ration of 98.0% basal added with 2.0% CO (R4). The completely randomized design was applied as design with five treatments consisted of five replications at each treatment. Each experimental unit was put four heads of super native hens. The significant treatments were tested by Duncan’s test. Variables measured were life body weight, slaughter body weight, carcass weight and carcass percentage as well as abdominal percentage. Results showed that utilization effect of coconut oil in ration had the same effects on percentages carcassand abdominal fat, but had significant effect on life body weight and carcass weight. Therefore, it was concluded that utilizatilization of coconut oil up to 2 percents in ratio increased life body weight and carcass weight. Keyword: carcass weight, coconut oil, super native chicken.
PENGARUH PENYULUHAN TERHADAP PETERNAK SAPI DI KECAMATAN KAWANGKOAN BARAT
Authors: Sondakh Rinaldo D , Oley F S , Sondakh B F.J , Sajow A S 
Published: May 2021

THE EXTENSION EFFECT ON ANIMAL SMALLHOLDER FARMERS AT WEST KAWANGKOAN DISTRICT. Study was conducted on April 2019 to evaluate the extension effect on the animal smallholder attitude in changing their skill development at West Kawangkoan district. Samples were determined by purposive sampling method involving 40 smallholders of local beef cattle. Data were analyzed byChi-Square analysis method. The data analyses showed that the expected frequency value ) was 290.35 to the affecting parameter and nothing effectexpectation value was 69.65. For the attitude variable, the expected frequency )value was 225.83 to the affecting parameter and nothing effectexpectation value was 54.17.Moreover, the skill variableshowed that the expected frequency )value was 225.83 to the affecting parameter and nothing effectexpectation value was 54.17.Analysis result of the calculatedwas 49.0954 > tabel of 5.991. The calculatedwasset at the area of . Therefore, it can be concluded that the extension activity at villages of theKanonang I, Kanonang II, Kanonang IV and Kanonang V affected the animal smallholder attitude in changing their skill development at West Kawangkoan district. Keywords : Chi square analysisi, Extension activity, smallholder attitude,
Pemilihan Staffberprestasi dengan menggunakan metode profile matching pada “COPPAMAGZ” (KOREAN ENTERTAINMENT MEDIA & COMMUNITY)
Authors: Mareta Ayu Datari , Wahyuni Asri 
Published: May 2021

The decision support system in selecting staff candidates at COPPAMAGZ (KOREAN ENTERTAINMENTMEDIA & COMMUNITY) is expected to assist in deciding the selection of outstanding staff. Previouslythere had never been an award for outstanding staff every year, it was undeniable that it was a difficulty inchoosing outstanding staff. To find out which staff is performing well, it is necessary to conduct aperformance appraisal of prospective staff. Conduct assessment results for outstanding staff using theprofile matching method. With the application of the profile matching method in selecting outstanding staffto solve problems that exist during the selection process of outstanding staff, so there are no errors indecision making. It is hoped that this effort can assist leaders in providing performance appraisals forprospective staff. After the leader gives a performance appraisal, the results of the assessment arecalculated using the profile matching method. The results of the selection of outstanding staff atCOPPAMAGZ (KOREAN ENTERTAINMENT MEDIA & COMMUNITY), namely a staff named Cindy witha data entry position with the final result of calculating a total of 5 ranks 1.
Keywords: Decision Support System, Outstanding Staff, Profile Matching
SISTEM INFORMASI AKUNTANSI PENGGAJIAN BERBASIS VB.NET PADA PT BANK PERKREDITAN RAKYAT (BPR) SANGGABUANA AGUNG KARAWANG
Authors: Sadiah Jamilatus , Indaryono Indaryono , Yusuf Arif Maulana 
Published: May 2021

The payroll system is an important function that is the responsibility of Human Resources Management. Its main function is to provide compensation to employees in the form of salary in exchange for their contribution to the organization / agency. Payroll is one of the processes in an organization that is vulnerable to problems. Slow data processing can result in slow presentation of slow report making so that it is also possible to delay payment of salaries to employees. Plus if something goes wrong making salary calculations inaccurate. This makes the payroll system needs to be supported by a good information system. The research methodology used by the author in this research is the System Development Life Sycle (SDLC) Waterfall method. The development of research methodology has several sequential stages, namely: planning (modeling), modeling (modeling), construction (construction), and the delivery of the system to the customers / users (deployment). Based on the problems found, The author proposes to PT Bank Perkreditan Rakyat (BPR) Sanggabuana Agung Karawang to use VB.Net, it is expected that with the proposed system can improve Payroll problems that occur at PT Bank Perkreditan Rakyat (BPR) Sanggabuana Agung. Based on this research, the existence of a computerized employee payroll calculation system is expected to become a system that is useful for the development of the company in the future, and it is hoped that it can fix the problem and can also facilitate the calculation of payroll.
Keywords : Accountimg Information System, Payroll, VB.Net Programming