bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sinkronisasi Estrus Sapi Peranakan Ongole di Kelompok Tani Sri Mulyo
Authors: Prastowo Sigit , Sunarto Sunarto , Lutojo Lutojo , Widyas Nuzul , Ratriyanto Adi 
Published: February 2021

<span lang="IN">Kelompok Tani Sri Mulyo merupakan kelompok peternak sapi </span><span>Peranakan Ongole (</span><span lang="IN">PO</span><span>) yang menghadapi kendala peningkatan angka kebuntingan. Permasalahan yang dihadapi adalah </span><span lang="IN">kejadian estrus / birahi tenang </span><span>sehingga penentuan </span><span lang="IN">waktu </span><span>Inseminasi Buatan (IB) tidak tepat dan kemudian berakibat pada kegagalan kebuntingan. Salah satu upaya </span><span> </span><span>untuk mengatasi hal tersebut dengan mengaplikasikan metode </span><span lang="IN">sinkronisasi estrus</span><span> (SE) agar tampilan </span><span lang="IN">estrus</span><span> mudah diamati </span><span lang="EN-ID">melalui </span><span>program pengabdian kepada masyarakat. Pengabdian ini dilakukan dalam 3 tahap, yaitu sosialisasi, pelaksanaan dan evaluasi. Informasi dan kesepakatan tentang program SE disosialisasikan pada tahap pertama, dilanjutkan dengan pelaksanaan di lapangan. Sebanyak 20 ekor sapi PO digunakan dalam program ini dan dari hasil pemeriksaan organ reproduksi diperoleh sebanyak 12 ekor sapi layak untuk disinkronisasi estrus. Hormon yang digunakan dalam program SE ini adalah </span><span lang="IN">PGF2</span><span>α dengan metode dua kali injeksi. Hasil SE didapatkan 10 ekor sapi teramati estrus, sedangkan 2 ekor terlewatkan pengamatannya. Inseminasi dengan semen beku kemudian dilakukan dan dievaluasi keberhasilannya setelah 21 dan 60 hari. Sebanyak 6 ekor tidak menunjukkan tanda-tanda estrus pada hari ke 21 setelah IB, dan 4 ekor dinyatakan bunting setelah evaluasi dengan <em>palpasi rektal</em> pada hari ke 60. Selanjutnya, kelahiran pedet didapatkan sebanyak 4 ekor. Berdasar hasil program SE dapat disimpulkan bahwa penggunaan program SE dapat meningkatkan jumlah sapi betina bunting di Kelompok Tani Sri Mulyo.</span>
Nadir CA-125&nbsp;Is Prognostic for Recurrence, but Not for Survival in Patients With Ovarian Cancer
Authors: Piatek Szymon , Panek Grzegorz , Lewandowski Zbigniew , Piatek Dominika , Kosinski Przemyslaw , Bidzinski Mariusz 
Published: February 2021

Abstract
Objective of this study was to evaluate nadir CA-125 in patients with epithelial ovarian cancer. 168 patients, who achieved complete remission (no clinical and radiological signs, CA-125< 35 U/ml) after first line treatment were enrolled in the study. The relation between CA-125 and survival were examined using generalized additive models applied to the Cox proportional hazards model. The median CA-125 concentration after the treatment was 10 U/ml (2.7-35 U/ml). No correlation between CA-125 nadir and overall survival was found (p linear = 0.13; p nonlinear = 0.52). Patients with CA-125 serum concentrations of 11 - 25 U/ml and 26 - 35 U/ml had significantly higher risk of recurrence compared to patients with CA-125 concentration ≤ 10 U/ml with HR = 1.865 (P <0.0024) and HR = 2.17 (P <0.018), respectively. Nadir CA125 was not relevant for risk of recurrence in FIGO I and II (p=0.75 and p=0.99, respectively), neoadjuvant chemotherapy (p=0.49 and p=0.26 respectively) or bevacizumab (p=0.066 and p=0.26). Nadir CA-125 is not related to overall survival. Risk of ovarian cancer relapse increase with CA-125 nadir level. However in patients with early stage disease or those receiving neoadjuvant chemotherapy or bevacizumab may not be associated with recurrence risk.
Meta Competency: Prerequisites of Msc Psychiatric Nursing Students Promoting. A Qualitative Study
Authors: sheikhbahaeddinzadeh Effat , ashktorab Tahereh , Ebadi Abbas 
Published: February 2021

Abstract
Background: Due to getting optimal psychiatric nursing care, competent psychiatric nurses is required. One approach for MSc psychiatric nursing students` optimal clinical competency is clinical education. Identifying the factors affecting on achieving maximum scientific and technical abilities, education would be more effective. This study aims to explore the meta competency required in MSc students in psychiatric nursing.Methods: This is a qualitative study with content analysis approach conducted on 21 participants in Iran. Sampling were done based on purposive sampling. Data were collected using individual semi structured and in-depth interviews. Collected data were analyzed using the conventional content analysis. The rigor of qualitative data were assessed using the 4 criteria proposed by Guba and Lincoln. Results: Four dimensions were revealed: (1)Thinking and clinical reasoning skills, (2)Dynamic learning, (3)Research and evidence based practice, (4)Human and organizational management. Each category had several distinct sub-categories.Conclusions: The results of this study showed that meta-competency for psychiatric nursing MSc students is multidimensional concept. The findings of the study can be used for educating MSc students in psychiatric nursing and evaluating meta competency. More studies on meta competency required psychiatric nursing students and designing an objective tool for assessing them meta competency in Iran are proposed.
A Natural Representation of Functions for Exact Learning
Authors: Irwin Benedict 
Published: February 2021

Abstract
We present a collection of mathematical tools and emphasise a fundamental representation of analytic functions. Connecting these concepts leads to a framework for `exact learning', where an unknown numeric distribution could in principle be assigned an exact mathematical description. This is a new
perspective on machine learning with potential applications in all domains of the mathematical sciences and the generalised representations presented here have not yet been widely considered in the context of machine learning and data analysis. The moments of a multivariate function or distribution are extracted using a Mellin transform and the generalised form of the coefficients is trained assuming a highly generalised Mellin-Barnes integral representation. The functions use many fewer parameters than contemporary
machine learning methods and any implementation that connects these concepts successfully will likely carry across to non-exact problems and provide approximate solutions. We compare the equations for the exact learning method with those for a neural network which leads to a new perspective on understanding what a neural network may be learning and how to interpret the parameters of those networks.
An Automated Jet Nebulizer with Dynamic Flow Regulation
Authors: Dampage Udaya , Ariyasinghe Malmindi , Pulleperuma Samanthi 
Published: February 2021

Abstract
PurposeThe present study is focused on designing an automated jet nebulizer that possesses the capability of dynamic flow regulation. In the case of existing equipment, a high fraction of the aerosol is lost to the atmosphere through the vent, during the exhalation phase of respiration. Specifically, 50% of the volume of aerosol generated, is wasted. Desired effects of nebulization may not achieve by neglecting this poor administration technique. There may be adverse effects like bronchospasm, and exposure to high drug concentrations.MethodsThe proposed nebulizer is composed of two modes as “Compressed Air” mode and “Oxygen Therapy” mode. The automated triggering from one mode to another will be dependent upon the percentage of oxygen saturation of the patient, monitored from the SpO2 sensor. The compressed airflow will be delivered to the patient according to his or her minute ventilation, derived with the aid of a temperature sensor-based algorithm.ResultsThe compressor circuitry controller ensures that the patient receives compressed air as per the flow rate decided by the system. At the end of the drug delivery, if the liquid level sensor detects the absence of medication within the nebulizer chamber, the nebulization process will be terminated.ConclusionsThe dynamic regulation of the motor speed with respect to the minute ventilation was accomplished successfully. A laminar flow was obtained from the outlet of the compressor towards the nebulizer tubing, and a turbulent flow was obtained within the chamber, as expected. No excessive turbulent flows or rotational flow patterns were detected. The result could certainly lead to the improvements of the existing nebulizers.
High Cytoplasmic and Membranous Versus Nuclear Talin-1 Expression Associated With Malignancy Potential and Poor Survival in Clear Cell Renal Cell Carcinoma
Authors: Zanjani Leili Saeednejad , Vafaei Somayeh , Abolhasani Maryam , Fattahi Fahimeh , Madjd Zahra 
Published: February 2021

Abstract
Using bioinformatics analysis Talin-1 protein was indicated as a potential prognostic focal adhesion factor in renal cell carcinoma (RCC). We, therefore, examined its protein expression levels and prognostic significant of Talin-1 with clinical follow-up in total of 269 tissue specimens from three important subtypes of RCC and 30 adjacent normal samples using tissue microarrays (TMAs). Then, we used combined analysis with B7-H3 to confirm that Talin-1 may be related to metastasis. The results showed that high membranous and cytoplasmic expression of Talin-1 was significantly associated with advanced nucleolar grade (P < 0.001, all), microvascular invasion (P = 0.007, P = 0.004, respectively), histological tumor necrosis (P = 0.020, P = 0.018), and invasion to Gerota’s fascia (P = 0.025, P = 0.050) in ccRCC. In addition, high membranous and cytoplasmic expression of Talin-1 was associated with significantly poorer disease-specific survival (P = 0.043, P = 0.024, respectively) and progression- free survival (P = 0.046, in cytoplasm). Moreover, increased cytoplasmic expression of Talin-1 High/B7-H3 High compared to the other phenotypes was associated with poor prognosis and progression of the disease in patients with distant metastasis. Collectively, these observations indicate that Talin-1 is an important molecule involved in the spread and progression of ccRCC when expressed particularly in cytoplasm and may serve as a novel prognostic biomarker in this subtype.
Prevalence and Factors Associated with Severe Anaemia Post-Caesarean Section at a Tertiary Hospital in Southwestern Uganda
Authors: Sivahikyako Sylvie Atosa , Owaraganise Asiphas , Tibaijuka Leevan , Agaba David Collins , Kayondo Musa , Ngonzi Joseph , Mugisha Julius , Kanyesigye Hamson 
Published: February 2021

Abstract
Background: Severe anaemia post-caesarean section adversely affects the woman and the new-born. While prenatal anaemia is extensively studied, the literature on post-caesarean section anaemia is limited and characteristics of women more likely to develop severe anaemia after caesarean section are unknown. This study aimed to determine the prevalence and factors associated with severe anaemia on day three post caesarean section.Methods: Women at day three post-caesarean section were consecutively enrolled in a cross-sectional study at Mbarara Regional Referral Hospital. We measured their haemoglobin (Hb) concentration and defined severe anaemia as Hb<7.0 g/dL. We excluded women diagnosed with severe pre-caesarean section anaemia and those who got blood transfusion without pre-transfusion Hb record. We interviewed the women and collected data on sociodemographic, obstetric, and medical characteristics. The primary outcome was severe anaemia post-caesarean section. We used logistic regression analysis to determine independent factors associated with severe anaemia after caesarean section. P-value <0.05 was considered statistically significant.Results: From December 2019 to March 2020, 427 of 431 screened women were enrolled in the study. Their mean age was 26.05 (SD ± 5.84) years. Three hundred thirteen (73.3%) had attended at least four antenatal care visits. The prevalence of severe post-caesarean section anaemia was 6.79 per cent. Fetal macrosomia (aOR 7.9 95%CI: 2.18-28.85, p<0.01) and having mild or moderate anaemia pre-caesarean section (aOR:9.6, 95%CI: 3.91- 23.77, p<0.01) were the factors associated with severe anaemia post-caesarean section.Conclusion: Severe anaemia post-caesarean section commonly occurs and is associated with anaemia preoperatively and delivering a foetus with macrosomia. Preoperative haemoglobin optimization and intraoperative blood conserving measures are imperative among such women to prevent postoperative anaemia—as well as post-caesarean section haemoglobin estimation before discharge from the hospital to detect anaemia early and optimise remedies.
Regulation of Matrix Metalloproteinase in Vascularization of Endothelial Cells On Extracellular Matrix Secreted By Mesenchymal Stem Cell Sheet
Authors: Ren Lina , Li Jinda , Yang Dan , Zhang Xuan , Shen Yuan , Chen Rui , Ma Dongyang , Ren Liling 
Published: February 2021

Abstract
Background: We have previously developed a prevascularized platform by seeding endothelial cells on the mesenchymal stem cell sheet and the technology provides a promising vascularization potential for wide applications in tissue engineering. However, the mechanism behind the interactions between stem cell sheet-derived matrix and endothelial cells (ECs) are still unknown. The purpose of this study is to investigate the role of MMPs in angiogenesis process in vitro.Methods: Human bone marrow-derived mesenchymal stem cells (hBMSCs) were cultured continually to form a thin cell sheet, and then green fluorescent protein (GFP)-labeled human umbilical vein endothelial cells (HUVECs) were seeded on the cell sheet to form a prevascularized system. Fibronectin, collagen I and MMPs immunofluorescence staining were used to observe their interaction changes. After that, HUVECs and hBMSCs were sorted by flow cytometry and RT-PCR was performed to quantify related gene expression of ECs and stem cells. In order to further explore the possible mechanism, the broad-spectrum MMPs inhibitor GM6001 was added into the medium to observe the effects of vascular network formation. Results: The immunofluorescence staining results showed that HUVECs secreted MMP-2 and membrane-type matrix metalloproteinase-1 (MT1-MMP) in the early stage of angiogenesis. MMPs degraded and remodeled the ECM to create space for vascular formation. HUVECs also promoted hBMSCs to secrete tissue inhibitors of metalloproteinase-2 (TIMP-2), which can stabilize blood vessels by avoiding excessive vascularization or vascular degradation in the later stage. Thus, HUVECs/hBMSCs co-culture group were beneficial for angiogenesis than the other two control groups. With the addition of the broad-spectrum matrix metalloproteinase inhibitor GM6001, RT-PCR results showed that the formation of EC lumen was blocked, while the mean fluorescence density of fibronectin and collagen I were increased.Conclusions: our study suggests that the MMP-2, MT1-MMP and TIMP-2 can synergistically regulate the angiogenesis. In addition, HUVECs and hBMSCs interact with each other in the process of vascular formation, and jointly regulate and promote the construction of lumen. These results also indicate a promising potential using the hBMSCs sheet as a platform for broad applications in engineering vascularized tissues.
Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity in Human Chordomas
Authors: Duan Wanru , Zhang Boyan , Li Xinqiang , Jia Shanhang , Xin Zong , Jian Qiang , Jian Fengzeng , Chou Dean , Chen Zan 
Published: February 2021

Abstract
Background: Chordoma is a rare and aggressive bone tumor with high recurrence. The intra-tumoral heterogeneity of chordomas is poorly understood, limiting the development of effective therapeutic strategies. Methods: Single-cell RNA sequencing was performed to delineate the transcriptomic landscape of chordomas. Six tumor samples of pathologically classical chordomas were obtained, and 33,737 cells that passed quality control were included in the analysis. Results: The main cellular populations identified with specific markers were: chordomas cells (6392, 47.6%), fibroblasts (6945, 20.6%), mononuclear phagocytes (4734, 14.0%), and T/NK cells (3944, 11.7%). Downstream analysis was performed according to each cellular population. There were six subclusters of chordomas, which exhibited properties of an epithelial-like extracellular matrix, and stem cells with immunosuppression. Although few immune checkpoint was detected on cytotoxic immune cells such as T and NK cells, there was strong immunosuppression exerted by Tregs and M2 macrophages. In addition, the cellular interactions indicated an enhanced TGF-β signaling pathway as the main mechanism for tumor progression, invasion, and immunosuppression in chordomas. Conclusion: Our study contribute to the clarification of intra-tumoral heterogeneity, and may pave the way to identify potential therapeutic targets in chordomas.
Factors Associated with Prevalence of Malaria Infection among Children under 5 Years of Age in Mozambique: 2015 vs 2018
Authors: Salvador Crizolgo De Jesus , Arnaldo Paulo , Rafael Bernardete Xavier , Cassy Annette , Candrinho Baltazar , Sabonete Acácio , Enosse Sónia 
Published: February 2021

Abstract
Background: Malaria is still a leading cause of morbidity and mortality among children under five years old in Mozambique. In this study we sought to determine the prevalence of malaria infection and its predictors among children six to 59 months old in Mozambique.Methods: Data from two national malaria indicators surveys in 2015 and 2018 were compared. In both surveys, blood samples were collected among children six to 59 months old to detect Plasmodium falciparum antigen by a rapid diagnostic test, and questionnaires were applied to collect socio-economic, demographic and vector control data from their households. Association of malaria rapid diagnostic test positivity with age, gender, residence, region, use of a vector control intervention, mother’s level of education and wealth index was assessed by logistic regression, using both univariate and multivariate analysis. A complex sampling logistic regression model was used to identify factors associated with malaria infection with estimated adjusted odds ratio and respective 95% confidence intervals. Results: A total of 9,068 children were tested for malaria infection of which 4,640 were in 2015 and 4,428 in 2018. The prevalence of malaria infection was 40.2% and 38.9% in 2015 and 2018, respectively. From 2015 to 2018, insecticide-treated nets ownership increased from 72.3% to 90.2% (p<0.001) and insecticide-treated nets use increased from 45.5% to 72.4% in children under the age of 5 years (p<0.001). In multivariate analysis, malaria infection was associated with region (north and central regions) and rural area for both surveys. Living in households with a wealth quintile lower than the wealthiest was associated with an increased odds of malaria infection (p<0.001). Maternal level of education and absence of an insecticide-treated net in the household were associated with malaria infection in 2015 (p<0.001) but not in 2018. Malaria infection was associated with age older than 12 months in 2015 and with age 24-35 months and 48-59 months in2018. Conclusions: Although insecticide-treated nets ownership and use have increased between the two surveys, prevalence of malaria infection remained stagnant. The main predictors of malaria infection were region, place of residence and socioeconomic status, underscoring the importance of broader developmental and socioeconomic factors on malaria prevalence.
Analysis of tectonic fracturing in the Mibladen ore deposit (Upper Moulouya, Morocco) and its impact on the Pb-Ba mineralization emplacement
Authors: Yaagoub Driss , Hinaje Saïd , Fartati Mohamed El , Gharmane Youssef 
Published: February 2021

Abstract
The MVT-type Pb-Ba mineralizations of the Mibladen ore deposit are hosted by Jurassic carbonates as well as Infracenomanian conglomerates and sandstones. The mineral paragenesis is mainly composed of galena and barite with lesser chalcopyrite and pyrite, accompanied by supergene oxidation minerals. This ore deposit is the result of a major epigenetic mineral stage with economic orebodies occuring as replacement of pre-existent carbonate rocks, fillings of karst cavities, interstratal joints, collapse-breccias, fractures and faults. Structural and microtectonic analyses we carried out in this ore deposit, allowed us to highlight two main fracture networks controlling ore deposition within karst cavities and interstratal joints: i) NNW-SSE to NNE-SSW trending tension gashes and normal faults; ii) ENE-WSW to E-W trending reverse faults with strike-slip components and transtensive relay zones. All of these structures are developed under a regional compressional tectonic regime divided into extensional and transtensional episodes (σ1-σ2 and σ2-σ3 permutations) with sub-meridian σ1 axis and sub-equatorial σ3 axis. This compressive tectonic event caused the uplift of Mibladen area and favored the circulation of mineralizing fluids along the NW-SE and ENE-WSW major faults such as Amourou and Aouli Faults, during the Infracenomanian period (Upper Jurassic-Early Cretaceous).
Volcanic Unrest at Hakone Volcano after the 2015 phreatic eruption — Reactivation of a Ruptured Hydrothermal System?
Authors: Mannen Kazutaka , Abe Yuki , Daita Yasushi , Doke Ryosuke , Harada Masatake , Kikugawa George , Honma Naoki , Miyashita Yuji , Yukutake Yohei 
Published: February 2021

Abstract
Since the beginning of the 21st century, volcanic unrest has occurred every 2–5 years at Hakone volcano. After the 2015 eruption, unrest activity changed significantly in terms of seismicity and geochemistry. Like the pre- and co-eruptive unrest, each post-eruptive unrest episode was detected by deep inflation below the volcano (~ 10 km) and deep low frequency events, which can be interpreted as reflecting supply of magma or magmatic fluid from depth. The seismic activity during the post-eruptive unrest episodes also increased; however, seismic activity beneath the eruption center during the unrest episodes was significantly lower, especially in the shallow region (~2 km), while sporadic seismic swarms were observed beneath the caldera rim, ~3 km away from the center. This observation and a recent InSAR analysis imply that the hydrothermal system of the volcano could be composed of multiple sub-systems, each of which can host earthquake swarm and show independent volume change. The 2015 eruption established routes for steam from the hydrothermal sub-system beneath the eruption center (≥ 150 m deep) to the surface through the cap-rock, allowing emission of super-heated steam (~ 160 ºC). This steam showed an increase in magmatic/hydrothermal gas ratios (SO2/H2S and HCl/H2S) in the 2019 unrest episode; however, no magma supply was indicated by seismic and geodetic observations. Net SO2 emission during the post-eruptive unrest episodes, which remained within the usual range of the post-eruptive period, is also inconsistent with shallow intrusion. We consider that the post-eruptive unrest episodes were also triggered by newly derived magma or magmatic fluid from depth; however, the breached cap-rock was unable to allow subsequent pressurization and intensive seismic activity within the hydrothermal sub-system beneath the eruption center. The heat released from the newly derived magma or fluid dried the vapor-dominated portion of the hydrothermal system and inhibited scrubbing of SO2 and HCl to allow a higher magmatic/hydrothermal gas ratio. The 2015 eruption could have also breached the sealing zone near the brittle–plastic transition and the subsequent self-sealing process seems not to have completed based on the observations during the post-eruptive unrest episodes.