bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drawn to Distraction: Anxiety Impairs Neural Suppression of Known Distractor Features in Visual Search
Authors: Salahub Christine , Emrich Stephen M. 
Published: June 2021

Abstract
When searching for a target, it is possible to suppress the features of a known distractor. This suppression may prevent distractor processing altogether or only after the distractor initially captures attention (i.e., search and destroy). However, suppression may be impaired in individuals with attentional control deficits, such as in high anxiety. In this study (n = 48), we used ERPs to examine the time course of attentional enhancement and suppression when participants were given pretrial information about target or distractor features. Consistent with our hypothesis, we found that individuals with higher levels of anxiety had lower neural measures of suppressing the template-matching distractor, instead showing enhanced processing. These findings indicate that individuals with anxiety are more likely to use a search-and-destroy mechanism of negative templates—highlighting the importance of attentional control abilities in distractor-guided search.
Influence of atmospheric circulation on glacier mass balance in western Tibet: an analysis based on observations and modeling
Authors: Zhu Meilin , Thompson Lonnie G. , Zhao Huabiao , Yao Tandong , Yang Wei , Jin Shengqiang 
Published: June 2021

AbstractGlacier changes on the Tibetan Plateau (TP) have been spatially heterogeneous in recent decades. The understanding of glacier mass changes in western Tibet, a transitional area between the monsoon-dominated region and the westerlies-dominated region, is still incomplete. For this study, we used an energy-mass balance model to reconstruct annual mass balances from October 1967 to September 2019 to explore the effects of local climate and large-scale atmospheric circulation on glacier mass changes in western Tibet. The results showed Xiao Anglong Glacier is close to a balanced condition, with an average value of -53±185 mm w.e. a-1for 1968-2019. The interannual mass balance variability during 1968-2019 was primary driven by ablation-season precipitation, which determined changes in the snow accumulation and strongly influenced melt processes. The interannual mass balance variability during 1968-2019 was less affected by ablation-season air temperature, which only weakly affected snowfall and melt energy. Further analysis suggests that the southward (or northward) shift of the westerlies caused low (or high) ablation-season precipitation, and therefore low (or high) annual mass balance for glaciers in western Tibet. In addition, the average mass balance for Xiao Anglong Glacier was 83±185, -210±185, and -10±185 mm w.e. a-1for 1968-1990, 1991-2012, and 2013-2019, respectively. These mass changes were associated with the variations in precipitation and air temperature during the ablation season on interdecadal time scales.
Surgical Techniques for Tonsillectomy and Perioperative Respiratory Complications in Children
Authors: Baijal Rahul G. , Wyatt Karla E. , Shittu Teniola , Chen Eugenia Y. , Wei Eric Z. , Tan Christine J. , Lee Maxwell , Mehta Deepak K. 
Published: June 2021

ObjectivesThe aim of this study was to determine the incidence of perioperative respiratory complications in children following tonsillectomy with cold and hot dissection surgical techniques.Study DesignThe study was a retrospective cohort study.SettingRetrospective chart review was performed for all children presenting for a tonsillectomy at Texas Children’s Hospital from November 2015 to December 2017.MethodsPre‐ and intraoperative patient factors, including surgical technique with cold or hot dissection (electrocautery or radiofrequency ablation), and perioperative anesthetic factors were collected to determine the incidence of perioperative respiratory complications.ResultsA total of 2437 patients underwent a tonsillectomy at Texas Children’s Hospital from November 2015 to December 2017. The incidence of perioperative respiratory complications was 20.0% (n = 487). Sickle cell disease, cardiac disease, reactive airway disease, pulmonary disease, age >2 and <3 years, and obesity, defined as a body mass index >95th percentile for age, were significant for overall perioperative respiratory complications. There was no difference in the incidence of perioperative respiratory complications in children undergoing tonsillectomy by cold or hot dissection.ConclusionPerioperative respiratory complications following tonsillectomy are more affected by patient factors than surgical technique.
Maternal Characteristics Mediating the Impact of Household Poverty on the Nutritional Status of Children Under 5 Years of Age in Bangladesh
Authors: Ghosh Probir Kumar , Das Pritimoy , Goswam Doli Rani , Islam Ausraful , Chowdhury Sukanta , Mollah Mohammad Manir , Harun Golam Dostogir , Akhtar Zubair , Chowdhury Fahmida 
Published: June 2021

Objectives: We explored the maternal characteristics that mediate the effect of household poverty on childhood undernutrition. Methods: We used the population-based Bangladesh Demographic Health Survey data from 2014 for demographic characteristics, child and maternal factors. Results: Of the 7173 under-5 children, 3456 (48.2%) had undernutrition. The prevalence of undernutrition was less common in wealthy households (poorest vs richest: adjusted prevalence ratio [aPR] = 1.37), mothers having history of antenatal care (ANC) visits (no visit vs ≥ 4 visits: aPR = 1.22), maternal higher education (no education vs higher education: aPR = 1.54), and mothers with good nutritional status (underweight vs healthy: aPR = 1.13). The risk of undernutrition (37.1%) was attributed to household wealth, mediated 55% by maternal factors; of which 20% by maternal education, 21% by ANC visits, and 14% by maternal nutritional status. Conclusions: Our study findings outlined higher maternal education, ≥ 4 ANC visits and good maternal nutritional status in mediating the impact of household wealth on childhood nutrition.
Conservative management of grade 4 and 5 renal injuries: A high-volume trauma center experience
Authors: Glykas Ioannis , Fragkoulis Charalampos , Paizis Theodoros , Papadopoulos Georgios , Stathouros Georgios , Ntoumas Konstantinos 
Published: June 2021

Introduction: Traumatic renal injuries represent a major public health issue concerning mostly young men. Over the last decades there is growing debate regarding the management of high-grade renal injuries due to the emerging role of conservative treatment. The aim of this study is to present our experience in the conservative management of patients presenting with grade 4 or grade 5 renal injuries in our department. Material and methods: In this retrospective, single center study we evaluated data from a total of 57 hemodynamically stable patients who were managed conservatively for grade 4 or grade 5 renal injuries from 2015 to 2019 in our high-volume trauma center. Grading was based on contrast enhanced abdominal computed tomography (CT) scans. Patients managed with immediate nephrectomy due to hemodynamic instability and patients who underwent immediate laparotomy due to concomitant injuries or penetrating wounds were excluded from the study. Results: A total of 54 patients diagnosed either with grade 4 or grade 5 renal trauma were finally successfully managed conservatively and included in the study. Median age was 34 years. Most patients presented with grade 4 renal trauma while five patients presented with grade 5 renal injury. Concomitant injuries not requiring surgical intervention were present in 48 patients. Continuous renal bleeding was detected in 15 patients (27.8%) and subsequent arterial embolization was performed with no further intervention required. Urine leak was diagnosed in 12 patients treated either by double j stent or by nephrostomy tube. Conclusions: Grade 4 and selected cases of grade 5 renal trauma can be treated conservatively with close monitoring and CT scan protocols in hemodynamic stable patients. In cases of continuous bleeding, arterial embolization can be performed. In cases of severe urine leak conservative management is also feasible either by inserting a double j stent or a nephrostomy tube.
A Guide to Using the Synthetic Control Method to Quantify the Effects of Shocks, Policies, and Shocking Policies
Authors: Adhikari Bibek 
Published: June 2021

Governments introduce various policies intending to improve the overall economy or to influence individual behavior. However, estimating the causal impact of these policies is challenging. I describe how the Synthetic Control Method (SCM) can be used in undergraduate econometrics or capstone courses to estimate the impact of economic policies. The SCM is a data-driven design that provides a systematic way of constructing a comparison group that looks very similar to the group implementing the policy. Thus, it allows us to estimate the policy’s impact by comparing the outcome variable’s post-policy path between the policy group and the comparison group. I review a broad range of policies and events that are analyzed using this method, briefly describe the theory behind the method, discuss various best practices, and provide a step-by-step implementation guide using the adoption of a value-added tax (VAT) by France as an example. JEL Classifications: C01, A1, A2
Ruxolitinib is an alternative to etoposide for patient with hemophagocytic lymphohistiocytosis complicated by acute renal injury: A case report
Authors: Yan Wei-Ling , Yang Shi-Long , Zhao Fen-Ying , Xu Xiao-Jun 
Published: June 2021

Introduction Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive production of inflammatory cytokines and multiple organs injury. Ruxolitinib, an oral selective JAK1/2 inhibitor, has recently shown efficacy and safety in the treatment of secondary HLH, which may be an alternative to intensive chemotherapy. Case report We report a case of a 2-year-old boy who presented to our institution with recurrent fever and acute renal failure. We made the diagnosis of Epstein-Barr virus related HLH based on the HLH-2004 protocol, and gave the treatment of ruxolitinib instead of etoposide. Management and outcome The patient received dexamethasone and continuous renal replacement therapy due to renal failure, but he still had fever and anuria. Given that the use of etoposide may deteriorate renal function, ruxolitinib was administered instead of etoposide. After 5 days of ruxolitinib treatment, the patient’s fever was resolved and renal function also gradually recovered 14 days later. Discussion Currently, dexamethasone, etoposide and cyclosporine A are the main drugs in HLH treatment. However, cytotoxic chemotherapy can temporally deteriorate organ damage and induce serious myelosuppression, which makes clinicians hesitate to implement these regimens. Ruxolitinib has shown efficacy in treating HLH without much toxicity in clinical trials. Thus, we suggest that ruxolitinib constitutes a treatment option for secondary HLH complicated by severe renal damage which may reduce toxic effects compared with intense chemotherapy.
Orbital anatomy magnetic resonance imaging in diplopic versus non-diplopic patients after glaucoma drainage device placement
Authors: Shah Saumya M , Kilgore Khin P , Bothun Erick D , Hunt Christopher H , Khanna Cheryl L 
Published: June 2021

Purpose: New-onset persistent diplopia has become a common complication after glaucoma drainage device (GDD) placement. Understanding the orbital anatomy of such patients may provide information regarding risk of diplopia, GDD selection, and post-operative management. The purpose of this study was to examine the orbital anatomic differences in diplopic and non-diplopic patients after GDD implantation using high-resolution MRI. Methods: Seven eyes ( N = 4 with diplopia and N = 3 without diplopia after GDD placement) of seven patients that had undergone placement of Baerveldt 250 (B250), Baerveldt 350 (B350), or Ahmed FP7 (FP7) GDD were prospectively enrolled at a single institution. All patients underwent a 3.0T orbital MRI with 3D volumetric T1 and T2 weighted sequence. Images were analyzed for orbital volume, axial length, orbital distances, presence of superior rectus-lateral rectus (SR-LR) band, position of GDD, and SR-LR angles. Results: Patients with diplopia had smaller mean ± SD orbital axial (911.5 ± 111.8 mm3 vs 931.7 ± 79.7 mm3) and coronal volumes (1162.5 ± 145.5 mm3 vs 1180 ± 34.6 mm3) compared to non-diplopic patients. Average orbital rim distances were larger for the diplopic group. The SR-LR displacement angle for diplopic patients was larger (101.6° ± 8.1 vs 94.7° ± 17.6) while the SR-LR quadrantic angle (86.6° ± 4.2 vs 89.1° ± 4.3) was smaller. SR-LR band was present and intact in all patients. GDD malpositioning was not evident in any patient. Conclusion: The decreased orbital axial and coronal volumes as well as increased orbital rim distances in diplopic patients suggests the need for further studies to understand the role of orbital anatomy in occurrence of diplopia. Dynamic MRI imaging may be helpful in identifying differences in extraocular muscle function that reveal an etiology of diplopia in patients with GDD implantation.
Seven years follow-up of corneal cross-linking (CXL) in pediatric patients: Evaluation of treated and untreated eye
Authors: Simantov Iliya , Or Lior , Gazit Inbal , Dubinsky-Pertzov Biana , Zadok David , Pras Eran , Hartstein Morris , Einan Lifshitz Adi 
Published: June 2021

Background: Retrospective cohort study evaluating long term keratoconus progression amongst cross-linking (CXL) treated pediatric patients in the treated and the fellow untreated eyes. Methods: Data on 60 eyes of 30 patients, 18 years old or younger, who underwent CXL in at least one eye was collected and analyzed. Follow-up measurements taken from the treated and untreated eye up to 7 years after CXL treatment, were compared to baseline measurements. Parameters included uncorrected distance visual acuity (UCDVA), best-corrected spectacle visual acuity (BCSVA), manifest refraction, pachymetry, corneal tomography, and topography. Results: Mean age of patients was 16 ± 2.1 years. For the treated eyes, during follow-up period mean UCDVA had improved (from 0.78 ± 0.22 at baseline to 0.58 ± 0.26 logMAR at 7 years; p = 0.13), as well as mean BCSVA (from 0.23 ± 0.107 at baseline to 0.172 ± 0.05 logMAR at 7 years; p = 0.37). The mean average keratometry showed a significant flattening (from 49.95 ± 4.04 to 47.94 ± 3.3 diopters (D); p < 0.001), However there was no change in the mean maximal keratometry. The mean minimal corneal thickness (MCT) showed a significant mild reduction of 26 µm ( p = 0.006). Although statistically insignificant, the mean manifest cylinder was also reduced to 2D ( p = 0.15). During the follow-up period, eight untreated eyes (26.6%) deteriorated and underwent CXL, while only one treated eye (3.33%) required an additional CXL. Conclusion: CXL is a safe and efficient procedure in halting keratoconus progression in the pediatric population, the fellow eye needs to be carefully monitored but only a 25% of the patients will require CXL in that eye during a period of 7 years.
Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective Study
Authors: Jurcau Anamaria , Nunkoo Vharoon Sharma 
Published: June 2021

Background: The study aims at identifying features predictive of early onset of dementia in Parkinson’s disease (PD). Methods: 103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up. Results: By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = −.621, p < 0.001) and insomnia (r = −.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017). Conclusion: Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.
Unstable Type III Wrisberg-type Lateral Discoid Meniscus: All-inside Arthroscopic Repair
Authors: Grassi Alberto , Pizza Nicola , Macchiarola Luca , Zaffagnini Stefano 
Published: June 2021

Background: The Type III Wrisberg-type represents the rarest subtype of discoid meniscus. It exhibits a normal non-discoid “C”-shape with possible posterior horn hypertrophy, but meniscotibial ligaments and capsular restraints are lacking, leading to a clinical scenario of knee pain, popping, and catching due to meniscal hypermobility. Moreover, concomitant tears can be present due to repeated meniscal traumas. Indications: Type III Wrisberg-type lateral discoid meniscus with hypermobility, dislocation, or tear. Technique Description: Through standard arthroscopic portals, the meniscus is reduced in its anatomical position (if displaced). Abnormal mobility and anatomy should be noted. All-inside sutures are used in the posterior horn and body to stabilize the meniscus to the capsule and popliteus tendon. In the case of radial tears, horizontal stitches are used. Results: Patients are expected to return to sport approximately 4 to 5 months after the procedure with relief of pain, popping sensation, and knee locking. Conclusion: Arthroscopic all-inside repair is an effective treatment for unstable and displaced Type III Wrisberg-type lateral discoid meniscus. However, the diagnosis can be challenging, especially without frank meniscal dislocation.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know
Authors: Arepally Gowthami M. , Ortel Thomas L. 
Published: June 2021

AbstractThe development of vaccines to fight COVID-19 has been a remarkable medical achievement. However, this global immunization effort has been complicated by a rare vaccine-related outcome characterized by thrombocytopenia and thrombosis in association with platelet-activating anti–platelet factor 4 antibodies. In this Spotlight, we will discuss the recently described complication of vaccine-induced immune thrombotic thrombocytopenia (VITT) occurring in response to certain COVID-19 vaccines. Although information about this clinical condition is rapidly evolving, we will summarize our current understanding of VITT.
Stigma from medication use: an under recognised burden of care
Authors: Kansra Sonal , Calvert Rachel , Jones Steve 
Published: June 2021

Children with respiratory diseases take treatments for the self-management of symptoms and to maintain disease control. Often, these treatments need to be taken in social environments like school. Respiratory treatments can foster a feeling of difference and stigmatisation, which negatively impact on the quality of life and adherence to treatment. Such perceptions can lead to a less than optimal disease control, a vicious cycle leading to further social exclusion and stigma. This aspect of “burden of treatment” is poorly recognised by clinicians. Recognition of how treatments and clinical practice can contribute to stigma, can help address this burden of care.Educational aimsTo understand the meaning of the term “stigma” within the context of respiratory health conditions and how medication or treatments can contribute to stigma in children and young people.To understand the potential impact of stigma on adherence, disease control and quality of life.To consider strategies to manage the stigma associated with health treatments across spheres of influence.
Inflammatory bowel disease and the lung in paediatric patients
Authors: Jochmann Anja , Trachsel Daniel , Hammer Jürg 
Published: June 2021

The prevalence of inflammatory bowel disease (IBD) has increased over the past 20 years. Pulmonary involvement in paediatric IBD is rare but may be missed since the spectrum of symptoms is broad and mimics other diseases. The most important differential diagnoses of pulmonary manifestations of IBD are infections and therapy-related side-effects. There is no gold standard to diagnose respiratory manifestations in children with IBD. Diagnostic tests should be chosen according to history and clinical presentation. Treatment of respiratory manifestations of IBD includes inhaled or oral corticosteroids and initiation or step-up of immunomodulatory IBD therapies.
In silico drug repositioning using deep learning and comprehensive similarity measures
Authors: Yi Hai-Cheng , You Zhu-Hong , Wang Lei , Su Xiao-Rui , Zhou Xi , Jiang Tong-Hai 
Published: June 2021

Abstract
Background
Drug repositioning, meanings finding new uses for existing drugs, which can accelerate the processing of new drugs research and development. Various computational methods have been presented to predict novel drug–disease associations for drug repositioning based on similarity measures among drugs and diseases. However, there are some known associations between drugs and diseases that previous studies not utilized.

Methods
In this work, we develop a deep gated recurrent units model to predict potential drug–disease interactions using comprehensive similarity measures and Gaussian interaction profile kernel. More specifically, the similarity measure is used to exploit discriminative feature for drugs based on their chemical fingerprints. Meanwhile, the Gaussian interactions profile kernel is employed to obtain efficient feature of diseases based on known disease-disease associations. Then, a deep gated recurrent units model is developed to predict potential drug–disease interactions.

Results
The performance of the proposed model is evaluated on two benchmark datasets under tenfold cross-validation. And to further verify the predictive ability, case studies for predicting new potential indications of drugs were carried out.

Conclusion
The experimental results proved the proposed model is a useful tool for predicting new indications for drugs or new treatments for diseases, and can accelerate drug repositioning and related drug research and discovery.
An ego-centred approach for the evaluation of spatial effects on health in urban areas based on parametric semi-variogram models: concept and validation
Authors: Sauzet Odile , Breiding Janne H. , Zolitschka Kim A. , Breckenkamp Jürgen , Razum Oliver 
Published: June 2021

Abstract
Background
Neighbourhood is a complex structure but of high relevance for health. Its operationalisation remains however a challenge.The aim of this work is to present a new application of the use of semi-variograms as an approach for the evaluation of spatial effects on health. For this, we propose to estimate two parameters providing a measure of an average neighbourhood or spatial effect at city level without having to predefine any notion of physical neighbourhood.

Methods
We present the statistical method to estimate the parameters of this correlation neighbourhood by fitting an exponential model to the empirical semi-variogram at short distances. With a simulation study, we show for which sample size and sampling density the method performs well and illustrate how to use the method with data from a birth cohort using the outcome birthweight.

Results
For small sample sizes (500) the method provides reliable estimates if the density of observations is high. For larger sample sizes other parameters influencing the quality of estimates are the maximal distance at which the semi-variograms are estimated.

Conclusions
Given the complexity of spatial scales relative to neighbourhood spatial processes, our approach offers the possibility to incorporate existing approaches to the operationalisation of neighbourhood in quantitative analyses while providing a measure of the part of health inequalities which could be possibly due to unmeasured spatial exposure as well as a measure of their spatial scale.