bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying the Lexicographic Maximum Solution of Min-Product Fuzzy Relational Inequalities for Finding the Optimal Pricing with a Fixed Priority in a Supply Chain System
Authors: Wu Yan-Kuen , Wen Ching-Feng , Hsu Yuan-Teng , Wang Ming-Xian 
Published: November 2021

Abstract
Fuzzy relational inequalities composed by the min-product operation are established to model the optimal pricing with fixed priority in a single product supply chain system. The solution algorithm has been proposed for solving such an optimization problem and finding the optimal solution (is called lexicographic maximum solution). In this study, a novel approach is proposed to finding the optimal pricing with fixed priority in a single product supply chain system. This approach is based on new properties of solution set in a min-product fuzzy relational inequality. These new properties allow us directly determine the optimal value of variable without many duplicate checks in the solution procedure. A numerical example is provided to illustrate the procedure.
Assessment of Long-term Groundwater Use Increase and Forest Growth Impact on Watershed Hydrology
Authors: Kim Wonjin , Kim Seongjoon , Kim Jinuk , Lee Jiwan , Woo Soyoung , Kim Sehoon 
Published: November 2021

Abstract
This study used Soil and Water Assessment Tool (SWAT) to investigate the impacts of groundwater use increase and forest growth on the watershed hydrology of Geum River basin (9,645.5 km2), South Korea. Groundwater use increase and forest growth data from 1976 to 2015 were prepared in 10-year interval and were reflected to SWAT corresponding to each decade. SWAT was calibrated in the aspect of evapotranspiration, soil moisture, and streamflow using the observation data. The model performance for streamflow was evaluated by coefficient of determination (R2), Nash-Sutcliffe efficiency (NSE), root mean square error (RMSE), and percent bias (PBIAS). The calibration achieved the average R2 value of 0.73 ~ 0.82, NSE value of 0.75 ~ 0.81, RMSE value of 0.53 ~ 2.35 mm/day, and PBIAS value of -2.51 ~ + 11.74%, respectively. The model performance for evapotranspiration and soil moisture was evaluated by R2. The calibration result of evapotranspiration and soil moisture achieved average R2 value of 0.45 and 0.44, respectively. The calibrated model evaluated the impact of two factors on watershed hydrology. Decadal increase of groundwater use has decreased groundwater flow and increased groundwater recharge while decadal forest growth has mainly increased evapotranspiration that led to the decrease of other hydrological components. Resultingly, the change of two factors have imposed temporal decrease of total runoff on the watershed while the influence of two factors on annual streamflow loss was bigger in lower flow rate.
The Relationship Between Spiritual Health With The Levels of Anxiety And Depression Among Cancer Patients
Authors: Tehrani Mohammad Ali Hossein , Yadollahpour Mohammad Hadi , Sadeghi Mohsen Vakili , Hamidia Angela 
Published: November 2021

Abstract
Purpose: Spiritual health is one of the dimensions of health associated with physical, social, and mental health. It can play an essential role in coping with stressful disease-related conditions. The purpose of this study was to evaluate the association between spiritual health and the level of anxiety and depression among cancer patients. Methods: In this cross-sectional study, 200 cancer patients were referred to a tertiary hospital in Iran. Hospital Anxiety and Depression Scale (HADS) and Spiritual Well Being Scale questionnaires were provided to the patients. Results: The mean score of spiritual health was 76.61±20.007 in cancer patients, which was considered moderate. The relationship between spiritual health and anxiety and between spiritual health and depression was significant. According to the Pearson correlation coefficient, the relationship between spiritual health and anxiety (r=-0.838) and depression (r=-0.834) was inverse. Furthermore, the relationship between spiritual health and anxiety (P<0.001) (r=-0.832) and depression (P<0.001) (r=-0.842) and the relationship between existential health and anxiety (P<0.001) (r=-0.830) and depression (P<0.001) (r=-0.813) were significant and inverse. Conclusion: The present study showed that spiritual health positively reduces anxiety and depression in cancer patients, promotes mental health, and accelerates and improves the disease.
In vitro regeneration of Piper longum L. and comparative RP-HPLC analysis of piperine production of in vitro and in vivo grown plants
Authors: Chatterjee Mousumi , Chatterjee Sabyasachi , Chandra Indrani 
Published: November 2021

Abstract
Piper longum L. is a well known spice plant belonging to the family Piperaceae with high pharmacognosy potential, but it is becoming threatened due to overexploitation. Thus, this investigation aims to standardize a cost effective protocol for in vitro propagation of this economically important plant. Internodal segments were used as explant for callogenesis in Murashige and Skoog medium with 3% sucrose and 0.8% agar, with NAA or 2,4 D. Optimum callus induction was observed in MS medium with 5.0 mg/L NAA. Calli were subcultured on shoot regeneration media containing different concentrations of cytokinin (KIN/BAP) along with 0.1mg/L NAA. Best shoot regeneration was obtained on MS media supplemented with 2.0 mg/L KIN and 0.1mg/L NAA. Induced shoots were rooted in either NAA or IBA and highest rooting was induced in MS medium enriched with 0.5 mg/L NAA. Rooted plantlets were acclimatized and 88% of hardened plants survived. Field emission scanning electron microscopic (FE-SEM) showed that regeneration from callus had occurred by somatic embryogenesis. A comparative study on identification and quantification of piperine ( the chief alkaloid of the cultivar) were done from root and fruit of both in vitro and in vivo grown plants through Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method. I n vitro grown fruit was found to have the maximum amount of piperine.
Optimal Division of Molecules Into Training And Test Sets With A New Tool To Predict Pharmacophore In 3D-QSAR
Authors: Tokat Tuğba Alp , Türkmenoğlu Burçin , Güzel Yahya 
Published: November 2021

Abstract
According to the descriptors in the pharmacophore model, dividing molecules into training and test sets serves to create a good model. It is difficult to track the Local Reactive Descriptor (LRD) effect of the pharmacophore at each interaction point in the 3D metric system. A subset of clusters of atoms can correspond to all or part of the pharmacophore structure. In this study, the multidimensional system of the subset was reduced to a one-dimensional index and the Vector Fingerprint Functions (VFF) of the molecules were created. Models were established by dividing molecules with close and similar VFFs into training and test sets. Sub-clusters were examined for all molecules by applying the Genetic Algorithm (GA). The model was predicted using the Leave One Out-Cross Validation (LOO-CV) method and verified with an external test set. The statistical results of the model obtained according to the division in the new method we developed (Q2 = 0.604 and R2 = 0.760 for training-80 and external test-20 sets, respectively) were compared with random and manual division results.
The Mirror Reversal Mechanism on Black Hole Collapse and Singularity Eruption in Cosmic Continuum
Authors: Wang Xijia 
Published: November 2021

Abstract
In the Big Bang Theory and the Black Hole Theory, the existing laws of physics all fail atthe singularity, and the singularity has become a blind spot in the existing scientific theories. In Cosmiccontinuum, the cosmic system collapse into a Schwarzschild black hole under the action of a stronggravitational field, and the Planck spheres at the center of the black hole continues to collapse into darkmass bodies, forming dark celestial body and singularity. The Schwarzschild radius is the upper limit ofa black hole, and the Planck sphere is the lower limit of a black hole. The singularity is the conversionpoint between the old and new cosmic systems. The singularity erupts the Planck spheres under theaction of a strong gravitational field, and the Planck spheres expands outward to form a new cosmicsystem. The Planck sphere is both the end of the old cosmic system and the starting point of the newcosmic system. The black hole collapse and the singularity eruption are mirror images of each other.The Planck sphere is the front of the mirror, and the singularity is the back of the mirror.
Ethanol/Water Separation by Linda Type A Membrane
Authors: Zheng Zhuoqi , Li Yan 
Published: November 2021

Abstract
Ethanol / Water Separation Technology is a long term research. LTA molecular sieve, which is an industrially important desiccant as a kind of zeolite molecular sieve. It is always used in the reverse osmosis method, which is one of the sea water desalination, and extraction of industrial ethanol method in the world. Membrane separation technology is widely used in cell science[1, 2], human science[1, 2], microbial science[3], military industry, battery technology[4, 5] and so on. With 2 years invention and attempts, prototype membrane is finished and the filtered data has also been measured in different side, such as Linda Type A(LTA) making temperature, raw material ratio of membrane preparation and filter curves. The physicochemical analysis of the samples before and after filtration was carried out. The manbrane filtration losses are very low and can be used with food grade filtration
Effect of COVID-19 Vaccination on Seizures in Patients With Epilepsy: a Multicenter, Retrospective Study
Authors: Fang Xiqin , Qiao Shan , Zhang Ranran , Yang Tingting , Wang Zhihao , Kong Qingxia , Sun Meihua , Geng Jianhong , Fang Chunyan , Chen Yanxiu , Sun Yanping , Zhang Dongmei , Qu Lixin , Shang Wei , Wang Jianguo , Liu Xuewu 
Published: November 2021

Abstract
Background: Previous study have shown that seizures may occur as a result of vaccination. This study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy (PWE) after being vaccinated with COVID-19 and to provide reference opinions for PWE to receive COVID-19 vaccine.Methods: We retrospectively enrolled PWE patients who were vaccinated against COVID-19 in the epilepsy centers of nine hospitals in China. The binary logistic regression analysis included variables with a P-value less than 0.1 in the univariate analysis.Results: The study included 290 patients, of which 40 (13.8%) developed seizures within 14 days after vaccination, whereas 250 (86.2%) remained seizure-free. The binary logistic regression analysis revealed statistical significance in seizures within three months before vaccination (P<0.001, OR=10.121, 95% CI: 4.301-23.816) and withdrawal or reduction of anti-seizures medications (ASM) during the peri-vaccination period (P=0.027, OR=4.452, 95% CI: 1.182-16.768). In addition, 32 of 33 patients (97.0%) who were seizure-free within three months before vaccination and had normal EEG results before vaccination did not have any seizures within 14 days following vaccination.Conclusions: SARS-CoV-2 may induce epilepsy through an inflammatory cascade. It is recommended to provide the COVID-19 vaccine to seizure-free patients for at least three months before vaccination, and the vaccination is safer if EEG result is normal. During peri-vaccination period, all PWE should be prohibited from reducing ASM dosage. PWE with well-controlled seizures who have discontinued ASM might consider resuming ASM during the peri-vaccination period if their EEG results are aberrant.
Neuroprotective Effects of Microfluidic Encapsulated Induced Conjunctival Mesenchymal Stem Cells Through Autophagy Modulation in a Parkinsonian Model
Authors: Mostafavi Hossein , Forouzandeh Meysam , Bigdeli Mohammad Reza , Nadri Samad , Eskandari Mehdi 
Published: November 2021

Abstract
Background and Aim: Parkinson's disease (PD) is a progressive neurodegenerative disorder in which cause is attributed to the alpha-synuclein (α-Syn) accumulation due to the decreases rated of autophagy. According to recent studies, cell therapy has been attracted much attention for PD treatment. Due to the many advantages mesenchymal stem cells (MSCs) have proposed, they have been considered a valuable resource for PD cell therapy. The present study aimed to investigate the therapeutic effect of Conjunctival MSCs (CJ-MSCs) on the autophagy manner and the expression of Mammalian target of rapamycin (mTOR), TH, and α-Syn in the parkinsonian rat model.Materials and Methods: our investigation has been performed using the Parkinson's model of rats. Stereotaxic 6-hydroxy dopamine (6-OHDA) was injected directly into the medial forebrain bundle (MFB) to induce Parkinson's disease. An apomorphine-induced rotation test was used to confirm the model establishment. CJ-MSCs were encapsulated in alginate microgel using a microfluidic system. The green fluorescent protein (GFP) labeled CJ-MSCs both encapsulated and free cells were transplanted into the rats' right striatum. Behavioral and molecular analyses have been carried out to evaluate the potency of CJ-MSCs (both encapsulated and free cells) on PD rats. The Rotation, Rotarod Open field test was recruited as the behavioral tests. Immunohistochemistry was used to determine the tyrosine hydroxylase (TH), and Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) has been performed for investigating the α-Syn and mTOR gene expression.Results: Our obtained results indicated that transplantation of CJ-MSCs leads to a decrease in the number of rotations while raising the balance and motor abilities. Immunohistochemistry analysis revealed an increase in the number of TH+ cells compared to the control group. The gene expression evaluation showed a significant reduction in mTOR and α-Syn mRNA levels than the control group. Our results also represented a significant difference between rats receiving encapsulated CJ-MSCs compared to the group received free CJ-MSCs.Conclusion: It seems that CJ-MSCs can promote the degradation of intracellular α-Syn by reducing mTOR and thus increase TH expression that led improve the motor functions of rats. Our results indicated the CJ-MSCs as a suitable source of MSCs to reduce PD complications.
Morphine and Dexamethasone Incorporated Cocktail Regimen Efficiently Reduced Postoperative Pain in Patients Undergoing Primary Total Knee Arthroplasty
Authors: Gong Jian , Li Yuancheng , Liu Shi , XU Cui , Gong Ying 
Published: November 2021

Abstract
Purpose: The present study was conducted to evaluate the pain-reducing efficacy and safety of the morphine and dexamethasone incorporated cocktail regimen in patients undergoing total hip arthroplasty (THA).Methods: The current study enrolled 75 patients and randomized them into three groups. The patients in group I were injected with morphine, dexamethasone, bupivacaine, flurbiprofen axetil, and normal saline. Patients assigned to group II were injected with dexamethasone, bupivacaine, flurbiprofen axetil, and normal saline. Patients in group III were given bupivacaine, flurbiprofen axetil, and normal saline. The visual analog scale (VAS) score and active and passive range of movement (ROM) were recorded and evaluated to compare the pain-controlling efficiency. The side effects of headache, dizziness, nausea, vomiting, wound leakage, and wound infection were monitored.Results: The patients in group I had the lowest VAS, and highest active ROM and passive ROM. The VAS reduced from day 1 to day 4, and the ROM increased conversely. The patients in group II presented a smaller reduction in VAS and a smaller increase in ROM, compared to the patients in Group III. The side effects of headache, dizziness, nausea, and vomiting were not recorded. Wound leakage was observed from 4 patients in group I (2 patients) and group II (2 patients). The was no statistical intergroup difference (p = 0.85). No wound infection symptoms were detected.Conclusions: Morphine and dexamethasone incorporated cocktail regimen efficiently reduced postoperative pain in patients undergoing primary total knee arthroplasty.Trial registration: Drug clinical trial registration system, CTR20181569. Registered 20 October 2018, http://www.chinadrugtrials.org.cn/clinicaltrials
Association Between Neck Circumference And Metabolic Syndrome In Women With Polycystic Ovary Syndrome
Authors: Liu Chang , Mu Liangshan , Ding Lin , Yang Haiyan , Chen Zimiao 
Published: November 2021

Abstract
Objective: To explore the correlation of neck circumference (NC) with metabolic syndrome (MetS) and metabolic risk factors, and assess the predictive value of NC for MetS in women with polycystic ovary syndrome (PCOS).Methods: This is a cross-sectional study recruited 633 women diagnosed with PCOS from January 2018 to June 2021. Anthropometric parameters, neck circumference, blood pressure, reproductive hormones, glycemic and lipid profile were measured in all subjects. The definition of MetS adopted in this study was the International Diabetes Federation (IDF) criteria.Results: Of the 633 subjects, MetS was diagnosed in 177 women (28.0%). PCOS women with larger NC had significantly greater values of body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist to hip ratio (WHR), systolic blood pressure, diastolic blood pressure, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β cell function (HOMA-β), triglyceride and high-density lipoprotein cholesterol. The prevalence of MetS, hypertention, obesity, central obesity, hyperglycemia and dyslipidaemia was also significantly higher in women with larger NC. Additionally, logistic regression analysis showed that women in the highest quartile of NC had the highest prevalence of MetS (RR=7.14, 95%CI: 1.82-28.01) after adjusting for confounding factors. Furthermore, NC was able to identify MetS in women with PCOS and the optimal cutoff points were 33.0 cm (Youden index = 0.44). The area under the curve (AUC) in predicting MetS by NC was 0.813，which was significantly larger than HC while comparable with BMI and WHR.Conclusions: Neck circumference was positively and independently correlated with the prevalence of MetS and showed a good predictive ability in women with PCOS. Therefore, NC could be recommended as a simple, stable and highly reproducible measuring method in the routine clinical assessment and long-term management of women with PCOS to screen those at high risk of MetS.
The Role of Gestational Diabetes Mellitus and Pelvic Floor 3D-Ultrasound Markers at the Second and Third Trimester of Pregnancy Predicting 6-18 Months Postpartum Urinary Incontinence: Preliminary Results From a Prospective Cohort
Authors: Filho Carlos Izaias Sartorão , Pinheiro Fabiane Affonso , Takano Luiz , Shetty Raghavendra Hallur Lakshmana , Nunes Sthefanie K. , Magyori Adriely Bittencourt Morgenstern , Magalhães Claudia G. , Junginger Baerbel , Bella Zsuzsanna Ilona Katalin de Jármy Di , Calderon Iracema M P , Barbosa Angélica M P , Rudge Marilza Vieira Cunha 
Published: November 2021

Abstract
Background
Gestational Diabetes Mellitus and long-term urinary incontinence (UI) have a severe impact on women's health. New methods to identify pregnant predictor risk factors of UI are needed. Our study investigated clinical and pelvic floor 3D-ultrasound markers in pregnant women at the second and third trimesters to predict 6-18 months postpartum UI.
Methods
This ongoing prospective cohort study included one hundred five nulliparous pregnant women with universal GDM screening and diagnosis, treated with nutritional and healthy lifestyle intervention. Pelvic floor 3DUltrasound was performed at the second and third trimesters of gestation. Clinical and pelvic floor 3DUltrasound biometry were collected. The ICIQ-SF and ISI questionnaires for UI were applied in the third trimester and 6-18 months postpartum. We performed univariate analysis (P<.20) to extract risk factors variables and multivariate logistic regression analysis (P<.05) to obtain the adjusted relative ratio for 6-18 months postpartum UI.
Results
In a preliminary result, a total of 93 participants concluded the follow-up. Using the variables obtained by the univariate analysis and after the adjustments for potential confounders, logistic regression analysis revealed that Gestational Diabetes Mellitus exposure was a strong and independent risk factor for 6-18 months postpartum UI (Adjusted RR 8.088; 95%CI 1.17-55.87; P:.034). In addition, higher hiatal area distension at rest from the second to the third trimester was negatively correlated with 6-18 months postpartum UI (Adjusted RR 0.966; 95%CI 0.93-0.99; P: .023).
Conclusion
Gestational Diabetes Mellitus was positively correlated with 6-18 months postpartum UI, and a higher hiatal area distension was negatively correlated with 6-18 months postpartum UI development.
Trial registration:
Regulatory approval was obtained from the Institutional Review Board (number 1.716.895) by “Botucatu Medical School of São Paulo State University (Unesp)” Ethics Committee.
Impact of Bronchopulmonary Dysplasia on Early Life Respiratory Morbidity in Children With Respiratory Distress Syndrome
Authors: Shin Jeong Eun , Jang Haerin , Han Jungho , Park Junsik , Kim Soo Yeon , Kim Yoon Hee , Eun Ho Seon , Lee Soon Min , Park Kook In , Sohn Myung Hyun , Park Min Soo , Kim Kyung Won 
Published: November 2021

Abstract
Bronchopulmonary dysplasia (BPD) can cause respiratory morbidity beyond the neonatal period. We aimed to analyze the influence of BPD on childhood lower respiratory illness (LRI) and asthma among patients diagnosed with respiratory distress syndrome (RDS). This case–control study analyzed data between 2002 and 2015 from a nationwide database. We included 55,066 children with RDS. Two-year LRI and asthma at ages 3 and 5 were assessed. Readmission for LRIs within 2 years of birth occurred in 53.9% and 37.9% of the BPD (n=9,470) and non-BPD (n=45,596) cases, respectively. In the BDP group, the median number of hospitalizations, mechanical ventilation and oxygen use rates were significantly higher, while the hospitalization duration was significantly longer (P<0.001 for all). The relative risk of BPD was 1.42 (1.39–1.45) on total readmission and 6.53 (5.96–7.15) on intensive care unit readmission. Asthma prevalences were significantly higher in BPD group (57.6% vs. 48.9% at age 3 and 44.3% vs. 38.2% at age 5, P<0.001). In children with RDS, BPD could affect repetitive and worse LRI as an independent risk factor for respiratory morbidity during the first 2 years of life. BPD may also be a crucial risk factor for asthma in preschoolers.