bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multicenter Retrospective Study of Vancomycin Dosing by Weight Measures in Children
Authors: Khare Manaswitha , Haag Meredith B. , Kneese Garrett , Austin Jared P. , Perlman Jeremy , Azim Aniqa , Orsi Carisse , Foster Byron A. 
Published: November 2021

OBJECTIVE
Vancomycin carries risks of treatment failure and emergent resistance with underexposure and renal toxicity with overexposure. Children with overweight or obesity may have altered pharmacokinetics. We aimed to examine how body weight metrics influence vancomycin serum concentrations and to evaluate alternative dosing strategies.

METHODS
This was a multicenter retrospective cohort study across 3 large, academic hospitals. Patients aged 2 to 18 years old who received ≥3 doses of intravenous vancomycin were included. Weight metrics included total body weight, adjusted body weight, ideal body weight, body surface area, and allometric weight. Outcomes included vancomycin concentration and ratios of area under the curve (AUC) to minimum inhibitory concentration (MIC). Regression analyses were used to examine which body-weight identifier predicted outcomes.

RESULTS
Of the 1099 children, 45% were girls, mean age was 9.0 (SD = 5.4) years, 14% had overweight, and 17% had obesity. Seventy-five percent of children had vancomycin concentrations in the subtherapeutic range by trough &lt;10 µg/mL, and 63% had a ratio of AUC to MIC &lt;400 μg-hr/mL. Three percent had a supratherapeutic initial trough &gt;20 µg/mL or ratio of AUC to MIC &gt;600 μg-hr/mL. Serum vancomycin concentrations were higher in children with overweight or obesity compared with children who were at a normal weight or underweight; the mean ratio of AUC to MIC also trended higher in the groups with overweight or obesity.

CONCLUSIONS
Most children received vancomycin regimens that produced suboptimal trough levels. Children with overweight or obesity experienced higher vancomycin trough levels than children of normal weight despite receiving lower total body weight dosing. Using the ratio of AUC to MIC was a better measure of drug exposure.
Point-of-Care Ultrasound Training in Pediatric Residency: A National Needs Assessment
Authors: Good Ryan J , O’Hara Kimberly L , Ziniel Sonja I. , Orsborn Jonathan , Cheetham Alexandra , Rosenberg Adam 
Published: November 2021

BACKGROUND AND OBJECTIVES
As point-of-care ultrasound (POCUS) evolves into a standard tool for the care of children, pediatric residency programs need to develop POCUS training programs. Few POCUS training resources exist for pediatric residents, and little is known about POCUS training in pediatric residencies. We aim to describe pediatric residency leadership perspectives regarding the value of POCUS and to elucidate the current state of POCUS training in pediatric residency programs.

METHODS
A group of pediatric educators and POCUS experts developed a novel survey followed by cognitive interviews to establish response-process validity. The survey was administered electronically to pediatric residency associate program directors between December 2019 and April 2020. Program characteristics, including region, setting, and size, were used to perform poststratification for analyses. We performed comparative analyses using program and respondent characteristics.

RESULTS
We achieved a 30% (58 of 196) survey response rate. Although only a minority of respondents (26%) used POCUS in clinical practice, a majority (56%) indicated that all pediatric residents should be trained in POCUS. A majority of respondents also considered 8 of 10 POCUS applications important for pediatric residents. Only 37% of programs reported any POCUS training for residents, primarily informal bedside education. Most respondents (94%) cited a lack of qualified instructors as a barrier to POCUS training.

CONCLUSIONS
Most pediatric residency programs do not provide residents with POCUS training despite its perceived value and importance. Numerous POCUS applications are considered important for pediatric residents to learn. Future curricular and faculty development efforts should address the lack of qualified POCUS instructors.
Advanced Tertiary Lymphoid Tissues in Protocol Biopsies are Associated with Progressive Graft Dysfunction in Kidney Transplant Recipients
Authors: Lee Yu Ho , Sato Yuki , Saito Mitsuru , Fukuma Shingo , Saito Masaya , Yamamoto Shigenori , Komatsuda Atsushi , Fujiyama Nobuhiro , Satoh Shigeru , Lee Sang-Ho , Boor Peter , Habuchi Tomonori , Floege Jürgen , Yanagita Motoko 
Published: November 2021

Significance Statement
Tertiary lymphoid tissues (TLTs) are frequently found in transplanted kidneys, but their prevalence and clinical significance remain uncertain. Serial protocol kidney transplant biopsies without signs of rejection were collected and TLTs staged according to the presence of proliferating lymphocytes and follicular dendritic cells. TLTs rapidly developed within 1 month after kidney transplantation in approximately half of the 214 patients. Advanced TLTs, defined as the presence of follicular dendritic cells, were associated with progressive decline in graft function independent of interstitial inflammation score. These findings suggest advanced TLTs are strongly associated with late graft dysfunction, even in the absence of rejection.

Background
Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues found in chronically inflamed organs. Although studies have documented TLT formation in transplanted kidneys, the clinical relevance of these TLTs remains controversial. We examined the effects of TLTs on future graft function using our histologic TLT maturity stages and the association between TLTs and Banff pathologic scores. We also analyzed the risk factors for the development of TLTs.

Methods
Serial protocol biopsy samples (0 hour, 1, 6, and 12 months) without rejection were retrospectively analyzed from 214 patients who underwent living donor kidney transplantation. TLTs were defined as lymphocyte aggregates with signs of proliferation and their stages were determined by the absence (stage I) or presence (stage II) of follicular dendritic cells.

Results
Only 4% of patients exhibited TLTs at the 0-hour biopsy. Prevalence increased to almost 50% at the 1-month biopsy, and then slightly further for 12 months. The proportion of advanced stage II TLTs increased gradually, reaching 19% at the 12-month biopsy. Presence of stage II TLTs was associated with higher risk of renal function decline after transplantation compared with patients with no TLT or stage I TLTs. Stage II TLTs were associated with more severe tubulitis and interstitial fibrosis/tubular atrophy at 12 months and predicted poorer graft function independently from the degree of interstitial inflammation. Pretransplantation rituximab treatment dramatically attenuated the development of stage II TLTs.

Conclusions
TLTs are commonly found in clinically stable transplanted kidneys. Advanced stage II TLTs are associated with progressive graft dysfunction, independent of interstitial inflammation.
Data Envelopment Analysis (DEA): Efisiensi Kinerja SD Muhammadiyah di Kabupaten dengan Akuntabilitas ”A”
Authors: Parwoto Parwoto , Susilawati Desi , Utami Anifah Syafitri 
Published: November 2021

This study aims to determine the efficiency level of the educational process performance in Muhammadiyah Elementary Schools in Kulon Progo and Bantul Regencies. The research method uses descriptive qualitative. Data collection through documentation and literature study. The research sample (DMU) is SD Muhammadiyah with accredited criteria "A". The research variables consisted of input variables (number of students, number of students participating in the UN, number of teachers) and output (national examination scores, namely Indonesian, Mathematics, and Science). Data analysis using DEA Model CRS and VRS with MaxDEA 8 Basic application. The results showed that: 1) the percentage of the number of SD Muhammadiyah in Bantul Regency (74%) that was accredited A was higher than that in Kulon Progo Regency (42%). 2) The average UN score in 2018 and 2019 SD Muhammadiyah in Kulon Progo Regency is higher than in Bantul Regency. 3) The average UN SD Muhammadiyah 2019 score in 2 (two) districts has decreased compared to 2018. 4) The percentage of the number of SD Muhammadiyah in Kulon Progo Regency that has a greater efficient performance (65% highest, 20% lowest) than in the Regency Bantul (highest 33%, lowest 10%). 5) The VRS model is proven to be able to check relatively better levels (highest 13 DMU, lowest 9 DMU) than the CRS model (highest 6 DMU, lowest 4 DMU).Keywords: DEA; Performance Efficiency; SD Muhammadiyah. AbstrakPenelitian ini bertujuan untuk mengetahui tingkat efisiensi relatif kinerja proses pendidikan pada SD Muhammadiyah di Kabupaten Kulon Progo dan Bantul. Metode penelitian menggunakan deskriptif kualitatif. Pengumpulan data melalui dokumentasi dan studi literatur. Sampel penelitian ini adalah SD Muhammadiyah di kabupaten Kulon Progo dan kabupaten Bantul yang terakreditasi “A” pada tahun 2018 dan 2019. Variabel penelitian terdiri dari variabel input (jumlah total siswa, jumlah siswa peserta UN, dan jumlah guru) dan output (nilai UN yaitu; Bahasa Indonesia, Matematika, dan IPA). Analisis data menggunakan DEA Model CRS dan VRS dengan aplikasi MaxDEA 8 Basic. Hasil penelitian menunjukkan bahwa: 1) prosentase jumlah SD Muhammadiyah di Kabupaten Bantul (74%) yang terakreditasi A lebih tinggi dibanding di Kabupaten Kulon Progo (42%). 2) Rata-rata nilai UN tahun 2018 dan tahun 2019, SD Muhammadiyah di Kabupaten Kulon Progo lebih tinggi dibanding di Kabupaten Bantul. 3) Rata-rata nilai UN tahun 2019 SD Muhammadiyah di 2 (dua) kabupaten tersebut mengalami penurunan dibanding tahun 2018. 4) Prosentase jumlah SD Muhammadiyah di Kabupaten Kulon Progo yang memiliki kinerja efisien lebih besar (tertinggi 65%, terendah 20%) dibanding di Kabupaten Bantul (tertinggi 33%, terendah 10%). 5) Model VRS terbukti mampu mendeteksi level efisiensi relatif lebih baik (tertinggi 13 DMU, terendah 9 DMU) dibanding Model CRS (tertinggi 6 DMU, terendah 4 DMU). Kata Kunci: DEA; Efisiensi Kinerja; SD Muhammadiyah.
Penerapan Sistem Persamaan Diferensial Linier pada Simulasi Debit Air pada Pipa
Authors: Efendi Rustam , Sagita Diang 
Published: October 2021

Salah satu permasalahan dalam kehidupan sehari-hari yang cukup rumit untuk diselesaikan adalah sistem aliran fluida (air) dalam bejana bertingkat. Pada penelitian ini, telah dilakukan pembuatan model sistem persamaan diferensial linear (SPDL) yang menggambarkan aliran air dari sistem instalasi air dengan tangki bertingkat serta membandingkan hasil simulasi numerik dari model dengan hasil eksperimen. Model SPDL dibangun dengan melibatkan observasi lapang secara langsung untuk menentukan nilai konstanta model (C1, C2 dan C3). Model yang telah dibangun disimulasikan secara numerik menggunakan metode Euler dengan 4 skenario nilaikonstanta. Hasil menunjukkan bahwa volume tangki A dan B serta laju perubahan volume airnya telah berhasil digambarkan oleh model SPDL yang telah dibangun dengan hasil yang paling mendekati hasil eksperimen adalah nilai C1 sebesar 0.01323 dan C2 sebesar 0.01091 dengan nilai RMSE 0.2599.
A comparative study on the effectiveness of budesonide nasal irrigation versus normal saline nasal irrigation in post endoscopic sinus surgery patients
Authors: Srinivasa Rao U. , Farooq S. A. S , Ranga Lakshmi J. 
Published: November 2021

: Comparative studies evaluating budesonide and saline nasal irrigations for patients with polyposis/ rhinosinusitis are deficient in the current literature. This study aimed to evaluate the effectiveness of budesonide nasal irrigations compared with saline irrigations during postoperative care of patients with rhinosinusitis.: A total of 100 patients who underwent functional Endoscopic Sinus SurgeryESS) were randomly divided into two groups (A and B) of 50 participants each (normal saline [NS] + budesonide irrigation and NS irrigation alone, respectively). Pre- and post operative evaluation was done with a 22-item sinonasal outcomes test (SNOT-22), and Lund Kennedy endoscopic (LKE scores) in second and sixth week. : The condition of the patients significantly improved in both intervention arms related to SNOT-22 and LKE score at each postoperative visit (Group A: p&#60;0.001, Group B: p&#60;0.001). The reduction of SNOT 22 score was higher in budesonide group by 10% (mean SNOT 22 score from 33.31 to 15.84) compared to normal saline group (mean SNOT 22 score from 37.49 to 22.24). The reduction of LKEscore was higher in budesonide group by 18.69% (mean LKE score from 4.49 to 2.71) compared to normal saline group (mean LKE score from 5.02 to 4). : Steroid nasal irrigation is a good option in postoperative EES patients. The difference of reduction of both SNOT 22 score and LKEscore was statistically significant (p &#60;0.05 and p&#60;0.01 respectively) by repeated contrast test. This study is one of the few comparative studies evaluating budesonide and saline nasal irrigations in post-ESS patients.
Activities of membarong on Dadak Merak mask dancers of Reog Ponorogo (Indonesia) and the effects on their teeth
Authors: Nurhalizah Hayyumu Farina 
Published: November 2021

Reog Ponorogo is an art that uses the Dadak Merak mask which is used by the dancer by biting on a wooden stick inside or commonly called cokotan. The Dadak Merak mask dancer is called pembarong, while the activity of playing the Dadak Merak mask is called membarong or mbarong. A pembarong may do a range of tricks, including kayang, gulungan, lifting the stacked Dadak Merak mask, and lifting the Dadak Merak mask while mounted on someone, all while the mask's weight exceeds 50 kg to 80 kg. The researchers wanted to know if mbarong action on the Dadak Merak Reog Ponorogo dancer produces tooth wear and how many degrees of wear there are on the dancer's teeth. Cross-tabulation analysis is the data analysis technique employed in this paper. This study included 20 pembarong respondents, ranging in age from 15 to 50 years old. The conclusions of this study show that mbarong exercise produced tooth wear in the dancers, with the most severe wear occurring in the first and second molars. The fulcrum of the Dadak Merak mask load on those teeth causes wear in the first and second molar teeth.
Avian Influenza Antibody Titer Of Laying Hens in Production Phase At District Penebel Tabanan Regency
Authors: Ikhsan Haris Muhamad 
Published: November 2021

Background: The virus of Avian Influenza (AI) H5N1 has become endemic in Indonesia since 2003. In 2012, the Avian Influenza outbreak at District Penebel caused chickens mortality in large numbers. One of the efforts to prevention the Avian Influenza outbreak is by vaccination. Therefore, supporting AI vaccination program needs diagnostic methods from post-vaccinated chickens that produce antibody titer by Hemagglutination Inhibition (HI) test. Purpose: The study aims to monitor the antibody of Avian Influenza phase I and phase II production in laying hens at District Penebel, Tabanan Regency. Method: 131 serum samples were collected from hens serums at poultry which has been sampled before. The serum sample is tested by Hemagglutination Inhibition (HI) test to calculate antibody titer. The serum is protective if the titer reacheas 24 or more, and the serum is unprotective if the titer is under 24. Data presented in 2x2 cross-sectional study contingent tabel and analyzed by Chi-Square (X2) non-parametric with the distribution. Results: Protective percentage of immunity level in production phase I in laying hens at District Penebel is 60,3%, whereas on production phase II is 43,6%. Data from the 2x2 contingent table showed an odd ratio of 1,9. The result of the Chi-Square (X2) analysis statistic represents immunity levels between production phase I and II are non-significance (p>0,05). Conclusion: Production phase I in laying hens has an immunity level 1,9x higher than production phase II. There is an association between the production phase and the protective immunity level of Avian Influenza.
Factors Affecting Fresh Semen Quality in Pasundan Cattle at UPTD BPPIBTSP Ciamis
Authors: Susandani Oky , Suprayogi Tri Wahyu , Damayanti Ratna , Ma'ruf Anwar 
Published: November 2021

Background: Pasundan cattle are local cattle native to Indonesia. One way to conserve beef cattle genetics is to use Artificial Insemination technology. The success of Artificial Insemination can be influenced by the quality of semen. Purpose: To determine factors affecting fresh semen quality in Pasundan cattle at UPTD BPPIBTSP Ciamis. Methods: The data were obtained through observations on seven Pasundan bulls in March 2021 towards fresh semen quality and some factors influencing it. The Pasundan bulls observed were seven productive males. Results: The fresh semen quality of Pasundan cattle, such as volume, color, and pH, showed good result,s but the average consistency and concentration of spermatozoa were still below the standard. The factors that can affect the fresh semen quality are the breed of beef cattle, age, body weight, feed, season, exercise, and frequency of semen storage. Conclusion: The determining factors that can cause the consistency and concentration of Pasundan cattle’s spermatozoa at UPTD BPPIBTSP Ciamis are feed and season.
Dilatated Cardiomyopathy In Two Month Old Puppy
Authors: Ikhsan Haris Muhamad , Putriningsih Putu Ayu Sisyawati 
Published: November 2021

Background: Canine dilated cardiomyopathy (DCM) is a disease that results in a decreased ability of the cardiac contraction to generate pressure to pump blood through the vascular system. DCM is characterized by dilation of the ventricles with ventricular wall thinning. Purpose: The DCM case in Indonesia is rarely reported; therefore, this paper contains information about dilatated cardiomyopathy in a 2-month-old puppy. Case Analyze: A two-month-old local dog arrived with a complaint about coughing, loss of appetite, fatigue, and swelling on extremities, also having a history of seizures and bloody diarrhea. Physical examination shows that the patient breathes using abdominal type and polypnea, tachycardia pulse, pale mucose, and dehydration. Electrocardiogram result shows tachycardia sinus and abnormality in the depression of ST-segment. Radiography examination shows heart dilation and liquid accumulation in the thoracic cavity and abdomen. Hematology routine examination shows microcytic hyperchromic anemia, leucocytosis, and eosinophilia. Feces examination resulted in negative. Pathology anatomy examination show dilatated cardio, pulmonum hepatization, fluid accumulation in the thoracic cavity and abdomen cavity. Result: According to anamnesis, clinical examination, laboratory examination, and anatomy pathology examination can be concluded that the dog, in this case, is diagnosed with dilatated cardiomyopathy.
Handling of Scabies in Domestic Cat at Q-one Petklinik Surabaya
Authors: Palgunadi Bagus Uda , Wangge Katarina Kole Grace , Wardhani Lailia Dwi Kusuma 
Published: November 2021

Background: Scabies is a skin disease caused by Sarcoptes scabiei. Scabies is transmitted through direct contact with animals affected by scabies or contact with the source of scabies mite in area of cat lives. Purpose: This study aims to determine the management of scabies at Q-One PetKlinik Surabaya. Method: Handling domestic cats affected by S.scabiei began with an interview with the owner and examinated with the physical condition of cats, and observed the body that was infected with S.scabiei. Scrabbing on scabs was conducted in the cat’s body which was located in the facial area, and followed by microscopic examination to observe the S.scabiei mite. Results: During April 2021, there were 13 domestic cats affected by scabies. Treatment for scabies was by administrated drugs containing 5% Permethrin. Cats were also given supportive therapy by grooming with antiectoparasite shampoo after two weeks from being given drugs. Conclusion: Handling cases of scabies in domestic cats at Q-One PetKlinik Surabaya is performed by cleaning the scab, applying an ointment containing 5% permethrin, and giving anti-histamine and anti-parasitic as well as providing supportive therapy in the form of grooming using shampoo containing anti-ectoparasites.
Early Detection of Children with Special Needs by Educators
Authors: Hamdan Stephani Raihana , Kusdiyati Sulisworo , Khasanah Andhita Nurul , Djamhoer Temi Damayanti 
Published: November 2021

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>The early detection of children with special needs is very important for educators, as they require special handling in the learning process so that they can develop optimally. The first important level for early detection is the early childhood education level. Early childhood teachers become agents who play a major role of early detection. Problems that occur due to late diagnosis of children with special needs often lead to learning and behavioural problems. If not handled properly, these disturbances will continue to the next level of further education. Knowledge of various types of disorders and early intervention in children with special needs must be the responsibility of early childhood education teachers to reduce the negative effects of any disruption that may occur. In order to assist teachers in early detection, this paper presents a study related to various developmental disorders that occur in children with special needs and the skills, techniques and steps that are needed for early detection. </span></p></div></div></div>
PENGENALAN SAINS SEJAK DINI MELALUI IT DAN ALAT PERAGA BAGI GURU PAUD DAN TK KECAMATAN POLOKARTO
Authors: Soeparmi Soeparmi , Yunianto Mohtar , Kusumandari Kusumandari 
Published: November 2021

<p>Telah dilakukan upaya dalam rangka mengenalkan sains bagi anak usia dini melalui pelatihan yang diikuti oleh 46 Guru dari 23 sekolah PAUD dan TK se kecamatan Polokarto. Kegiatan dilaksanakan dalam 2 tahap, tahap 1 pengenalan sains berbasis IT yaitu mengenalkan aplikasi <em>Augmented Reality</em> <em>AR Animal</em> dan <em>Planet AR</em>, tahap berikutnya pengenalan sains menggunakan alat peraga yaitu alat peraga kesetimbangan dan Angka digital. Sebelum dilakukan pelatihan sebagian besar belum dapat menimplementasikan IT dan alat peraga dalam mengenalkan sains ke anak didik, setelah pelatihan dari hasil angket yang di sebarkan semua Guru dapat memanfaatkan media pembelajaran berbasis IT dan juga memahami dalam mengenalkan sains melalui alat peraga.</p>
Suture Fixation of a Pediatric Pelvic Ring Injury
Authors: LaTulip Scott M. , DiCenso Stefano M. , Romeo Nicholas M. , Mistovich R. Justin 
Published: October 2021

Case:
A 2-year-old male child presented as a polytrauma after having been run over by a motor vehicle. His orthopaedic injuries included a pelvic ring injury, a displaced subtrochanteric femur fracture, and a clavicle fracture. His pelvic ring injury ultimately required open reduction with suture fixation after failure of closed management.

Conclusion:
Pelvic ring injuries are relatively uncommon in young children, and even more rarely do they require surgical intervention. We detail the case of one such patient who required open management of his anteroposterior compression II pelvic ring injury, and we describe an alternative fixation technique using suture wire.
Intramedullary Foreign Bodies within Fresh-Frozen Fibular Cortical Allograft
Authors: Putko Robert M. , Rodkey Daniel L. , White Sharese M. 
Published: October 2021

Case:
A 71-year-old man with a proximal humerus fracture nonunion underwent surgery augmented by a fibular cortical strut allograft. On placing the allograft within the proximal humerus, fluoroscopic images showed 2 foreign bodies found to be broken drill bits located within the allograft. The drill bits were extracted, and the allograft was reprepared for use.

Conclusion:
After 2 years of follow-up, no significant sequela related to the foreign bodies was noted. To the best of our knowledge, this case report represents the first-of-its-kind occurrence of broken drill bits found within bone allograft.