bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA damage and repair in peripheral blood mononuclear cells after internal ex vivo irradiation of patient blood with 131I
Authors: Schumann S. , Scherthan H. , Pfestroff K. , Schoof S. , Pfestroff A. , Hartrampf P. , Hasenauer N. , Buck A. K. , Luster M. , Port M. , Lassmann M. , Eberlein U. 
Published: November 2021

Abstract

Aim
The aim of this study was to provide a systematic approach to characterize DNA damage induction and repair in isolated peripheral blood mononuclear cells (PBMCs) after internal ex vivo irradiation with [131I]NaI. In this approach, we tried to mimic ex vivo the irradiation of patient blood in the first hours after radioiodine therapy.

Material and methods
Blood of 33 patients of two centres was collected immediately before radioiodine therapy of differentiated thyroid cancer (DTC) and split into two samples. One sample served as non-irradiated control. The second sample was exposed to ionizing radiation by adding 1 ml of [131I]NaI solution to 7 ml of blood, followed by incubation at 37 °C for 1 h. PBMCs of both samples were isolated, split in three parts each and (i) fixed in 70% ethanol and stored at − 20 °C directly (0 h) after irradiation, (ii) after 4 h and (iii) 24 h after irradiation and culture in RPMI medium. After immunofluorescence staining microscopically visible co-localizing γ-H2AX + 53BP1 foci were scored in 100 cells per sample as biomarkers for radiation-induced double-strand breaks (DSBs).

Results
Thirty-two of 33 blood samples could be analysed. The mean absorbed dose to the blood in all irradiated samples was 50.1 ± 2.3 mGy. For all time points (0 h, 4 h, 24 h), the average number of γ-H2AX + 53BP1 foci per cell was significantly different when compared to baseline and the other time points. The average number of radiation-induced foci (RIF) per cell after irradiation was 0.72 ± 0.16 at t = 0 h, 0.26 ± 0.09 at t = 4 h and 0.04 ± 0.09 at t = 24 h. A monoexponential fit of the mean values of the three time points provided a decay rate of 0.25 ± 0.05 h−1, which is in good agreement with data obtained from external irradiation with γ- or X-rays.

Conclusion
This study provides novel data about the ex vivo DSB repair in internally irradiated PBMCs of patients before radionuclide therapy. Our findings show, in a large patient sample, that efficient repair occurs after internal irradiation with 50 mGy absorbed dose, and that the induction and repair rate after 131I exposure is comparable to that of external irradiation with γ- or X-rays.
Comparing the clinical performance and cost efficacy of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 in the diagnosis of recurrent prostate cancer: a Markov chain decision analysis
Authors: Alberts Ian , Mingels Clemens , Zacho Helle D. , Lanz Sabine , Schöder Heiko , Rominger Axel , Zwahlen Marcel , Afshar-Oromieh Ali 
Published: November 2021

Abstract
Purpose
Amongst others, [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 are available for the detection of recurrent prostate cancer (rPC). There are currently limited data comparing the performance of these two radioligands with respect to clinical outcomes or their cost efficacy, which this study aims to address.

Methods
Two hundred and forty-four patients undergoing PSMA PET/CT for rPC were retrospectively analysed for this study (one hundred and twenty two with each radiopharmaceutical) to generate rates of PET positivity, negativity and unclear findings. Patients underwent follow-up to determine the rate of additional examinations and to confirm PET findings. A Markov chain decision analysis was implemented to model clinical decision-making processes and to analyse clinical performance of the two tracers. We determine their clinical cost efficacies using cost data from several countries where both radiotracers are in routine use.

Results
The PET positivity rate was non-significantly higher for [18F]PSMA-1007 compared to [68Ga]Ga-PSMA-11 (91.8% vs. 86.9%, p = 0.68), whereas the rate of uncertain findings was significantly greater (17.2% vs. 8.25%, p = 0.02). The probability of a true positive finding was higher for [68Ga]Ga-PSMA-11 (0.90, 95% CI 0.70-0.98) vs. [18F]PSMA-1007 (0.81, 95% CI 0.66–0.91). A significantly (p < 0.0001) higher PPV for [68Ga]Ga-PSMA-11 (0.99, 95% CI 0.99–1.0 vs. 0.86) was found compared to [18F]PSMA-1007 (0.86, 95% CI 0.82–1.00). Intervention efficacy analysis favoured [68Ga]Ga-PSMA-11, where the number needed to image (to achieve a true positive finding) was 10.58 and the number needed to image to harm (to achieve a false positive finding) was − 8.08. A cost efficacy analysis favours [68Ga]Ga-PSMA-11 in three of the four jurisdictions analysed where health economic data was available (Switzerland, Israel, Australia) and [18F]PSMA-1007 in one jurisdiction (Denmark).

Conclusion
The analysis reveals a non-significantly higher PET positivity rate for [18F]PSMA-1007, but finds significantly greater rates of uncertain findings and false positive findings when compared to [68Ga]Ga-PSMA-11. We find differences in the two tracers in terms of clinical performance and cost efficacy. The method presented herein is generalisable and can be used with clinical or cost data for other countries or tracers.
Spatiotemporal non-uniformly correlated beams
Authors: Hyde Milo W. 
Published: November 2021

AbstractWe present a new partially coherent source with spatiotemporal coupling. The stochastic light, which we call a spatiotemporal (ST) non-uniformly correlated (NUC) beam, combines space and time in an inhomogeneous (shift- or space-variant) correlation function. This results in a source that self-focuses at a controllable location in space-time, making these beams potentially useful in applications such as optical trapping, optical tweezing, and particle manipulation. We begin by developing the mutual coherence function for an ST NUC beam. We then examine its free-space propagation characteristics by deriving an expression for the mean intensity at any plane $$z \ge 0$$

z
≥
0

. To validate the theoretical work, we perform Monte Carlo simulations, in which we generate statistically independent ST NUC beam realizations and compare the sample statistical moments to the corresponding theory. We observe excellent agreement amongst the results.
Inter-microbial competition for N and plant NO3− uptake rather than BNI determines soil net nitrification under intensively managed Brachiaria humidicola
Authors: Egenolf Konrad , Schad Philipp , Arevalo Ashly , Villegas Daniel , Arango Jacobo , Karwat Hannes , Cadisch Georg , Rasche Frank 
Published: November 2021

AbstractBrachiaria humidicola (syn. Urochloa humidicola) has been acknowledged to control soil nitrification through release of nitrification inhibitors (NI), a phenomenon conceptualized as biological nitrification inhibition (BNI). Liming and N fertilization as features of agricultural intensification may suppress BNI performance, due to a decrease in NI exudation, increased NH3 availability and promotion of ammonia oxidizing bacteria (AOB) over archaea (AOA). A 2-year three-factorial pot trial was conducted to investigate the influence of soil pH and soil microbial background (ratio of archaea to bacteria) on BNI performance of B. humidicola. The study verified the capacity of B. humidicola to reduce net nitrification rates by 50 to 85% compared to the non-planted control, irrespective of soil pH and microbial background. The reduction of net nitrification, however, was largely dependent on microbial N immobilization and efficient plant N uptake. A reduction of gross nitrification could not be confirmed for the AOA dominated soil, but possibly contributed to reduced net nitrification rates in the AOB-dominated soil. However, this putative reduction of gross nitrification was attributed to plant-facilitated inter-microbial competition between bacterial heterotrophs and nitrifiers rather than BNI. It was concluded that BNI may play a dominant role in extensive B. humidicola pasture systems, while N immobilization and efficient plant N uptake may display the dominant factors controlling net nitrification rates under intensively managed B. humidicola.
Vasculogenic mimicry correlates to presenting symptoms and mortality in uveal melanoma
Authors: Sabazade Shiva , Gill Viktor , Herrspiegel Christina , Stålhammar Gustav 
Published: November 2021

Abstract
Purpose
Fluid-conducting extracellular matrix patterns known as vasculogenic mimicry (VM) have been associated with poor prognosis in uveal melanoma and other cancers. We investigate the correlations between VM, presenting symptoms, mortality, and the area density of periodic acid-Schiff positive histological patterns (PAS density).

Methods
Sixty-nine patients that underwent enucleation for uveal melanoma between 2000 and 2007 were included. Clinicopathological parameters presenting symptoms and outcomes were collected. Histological tumor sections were evaluated for VM and PAS density was quantified with digital image analysis.

Results
Thirty-four patients (49%) presented with blurred vision. 18 (26%) with a shadow in the visual field, 7 (10%) with photopsia and/or floaters, and 2 (3%) with metamorphopsia. Nine patients (13%) had no symptoms at all. Median follow-up was 16.7 years (SD 2.6). A shadow in the visual field, but no other symptom, was positively correlated with the presence of VM (φ 0.70, p < 0.001) and greater PAS density (p < 0.001). In multivariate regression, retinal detachment (RD), presence of VM, and PAS density ≥ median were independent predictors of a shadow, but not tumor distance to the macula, tumor apical thickness, tumor diameter, or ciliary body engagement. The presence of VM was associated with significantly shorter cumulative disease-specific survival (Wilcoxon p = 0.04), but not PAS density ≥ median, presenting symptoms or RD (p > 0.28).

Conclusion
Tumors from uveal melanoma patients that report a visual field shadow are likely to display VM and greater PAS density, likely explaining the previously reported association between this symptom and poor prognosis.
A novel linguistic decision-making method based on the voting model for large-scale linguistic decision making
Authors: Yan Li , Pei Zheng 
Published: November 2021

AbstractThe notable characteristic of large-scale linguistic decision-making problems is that there are so many decision makers who provide linguistic assessments by using fuzzy linguistic representation models. In real-world applications, fuzzy linguistic terms mean different things for different people, and linguistic assessments based on different linguistic representation models may be simultaneous in the same large-scale linguistic decision-making problems. To this end, a novel linguistic decision-making method based on the voting model is proposed in the paper to deal with multi-linguistic assessments provided by decision makers. In large-scale linguistic decision process, evaluation-based voting is defined and multi-linguistic decision matrix is designed to represent multi-linguistic assessments provided by decision makers by using different linguistic representation models, and properties of the decision matrix are analyzed to show that linguistic assessments based on different linguistic representation models can be simultaneously represented. Based on multi-linguistic decision matrix, a new linguistic decision-making framework is developed to deal with large-scale linguistic decision-making problems with multi-linguistic assessments, in which normalization of multi-linguistic decision matrix and trust degrees of linguistic terms are contained, and more important, based on trust degrees of linguistic terms and 2-tuple fuzzy linguistic aggregation operators, an uniform fusion method of multi-linguistic assessments is proposed to aggregate multi-linguistic assessments of large-scale linguistic decision-making problems. Finally, user experiences of shared bikes, which are a large-scale linguistic decision-making problem in real-world applications, are employed to show the new decision-making framework and the uniform fusion method of multi-linguistic assessments, and furthermore, compared with existing linguistic decision-making methods analyzed in the example, it seems that multi-linguistic decision matrix and the uniform fusion method are useful and effective tools to deal with large-scale linguistic decision-making problems with multi-linguistic assessments.
Gross hematuria after SARS-CoV-2 vaccination: questionnaire survey in Japan
Authors: Matsuzaki Keiichi , Aoki Ryousuke , Nihei Yoshihito , Suzuki Hitoshi , Kihara Masao , Yokoo Takashi , Kashihara Naoki , Narita Ichiei , Suzuki Yusuke 
Published: November 2021

Abstract
Background
Recent clinical reports indicate a correlation between gross hematuria after the coronavirus 2019 (COVID-19) vaccination in patients with glomerulonephritis, especially immunoglobulin A nephropathy (IgAN). Furthermore, healthcare workers in Japan were initially vaccinated with an mRNA vaccine from February 17, 2021, and some of them experienced gross hematuria after receiving the vaccination.

Methods
We conducted a web-based survey of the councilor members of the Japanese Society of Nephrology (581 members, 382 facilities) to elucidate the relationship between gross hematuria and COVID-19 vaccination.

Results
In the first survey, 27 cases (female: 22, 81.5%) of gross hematuria were reported after receiving a COVID-19 vaccination. Of them, 19 (70.4%) patients were already diagnosed with IgAN at the occurrence of gross hematuria. Proteinuria appeared in eight of the 14 (57.1%) cases with no proteinuria before vaccination and hematuria in five of the seven (71.4%) cases with no hematuria before vaccination. The second survey revealed that a renal biopsy was performed after vaccination in four cases, all of whom were diagnosed with IgAN. Only one case showed a slightly increased serum creatinine level, and no patients progressed to severe renal dysfunction.

Conclusion
This study clarified the clinical features of gross hematuria after a COVID-19 vaccination. Because there was no obvious progression to severe renal dysfunction, safety of the COVID-19 vaccination is warranted at least in the protocol of inoculation twice.
Student teachers’ knowledge integration across conceptual borders: the role of study approaches, learning strategies, beliefs, and motivation
Authors: Lehmann Thomas 
Published: November 2021

AbstractThere is widespread agreement that student teachers need to construct an integrated knowledge base across multiple domains. This study examined the contributions of intraindividual factors of self-regulated learning to explaining student teachers’ (a) integration of knowledge across topics and domains (i.e., integrative learning) and (b) disjointed processing of potentially domain-specific learning content (i.e., separative learning). The factors considered were study approaches; cognitive, metacognitive, and resource-related learning strategy use; epistemological and pedagogical beliefs; and career choice motivation. The study applied a cross-sectional survey design and examined separative and integrative learning in N = 103 student teachers by way of multiple regression analyses with backward eliminations. A key finding is that deep and strategic study approaches and certain cognitive learning strategies contributed significantly to explaining integrative learning in student teachers. Epistemological and pedagogical beliefs were not able to predict integrative learning. Regarding separative learning, the study identified the surface study approach, specific epistemological and pedagogical beliefs, and the “usefulness” motive for career choice as positive predictors and critical thinking as a negative predictor. The study demonstrates differences in how integrative and separative learning are shaped by distinct intraindividual factors. Implications are discussed with regard to student teachers’ self-regulated learning and pre-service teacher education.
Decomposable Specht Modules Indexed by Bihooks II
Authors: Muth Robert , Speyer Liron , Sutton Louise 
Published: November 2021

AbstractPreviously, the last two authors found large families of decomposable Specht modules labelled by bihooks, over the Iwahori–Hecke algebra of type B. In most cases we conjectured that these were the only decomposable Specht modules labelled by bihooks, proving it in some instances. Inspired by a recent semisimplicity result of Bowman, Bessenrodt and the third author, we look back at our decomposable Specht modules and show that they are often either semisimple, or very close to being so. We obtain their exact structure and composition factors in these cases. In the process, we determine the graded decomposition numbers for almost all of the decomposable Specht modules indexed by bihooks.
Work-related problems faced by coordinators of organ, cell, and tissue transplantations in Poland and possible ways of ameliorating them
Authors: Kamiński Artur , Bury Marcin , Rozenek Hanna , Banasiewicz Jolanta , Wójtowicz Stanisław , Owczarek Krzysztof 
Published: November 2021

AbstractIn recent years in Poland, the numbers of reported potential cadaveric donors of organs, tissues, and cells, and the numbers of transplantations being carried out seem to be low in the context of the size of the country population and the presumed consent legal principle which rules transplantations. This research project was carried out on 109 Polish transplant coordinators by means of a questionnaire created specifically for this study. The goal of the project was to detect problems specific to transplant coordinators working in Poland which, when properly addressed, might improve the efficacy of transplantation network within the Polish health care system. The results suggest that Polish transplant coordinators face a variety of issues in their work. It appears that the most important interventions which could improve working conditions for in this population and—as a result—also improve the efficacy of transplantation network in Poland could include: (1) a variety of training programs for transplant coordinators; (2) a social campaign promoting transplantations and spreading awareness of the transplantation-related legislation; and (3) introduction of changes in the regulations pertaining to medical professions in Poland.
A Riemannian rank-adaptive method for low-rank matrix completion
Authors: Gao Bin , Absil P.-A. 
Published: November 2021

AbstractThe low-rank matrix completion problem can be solved by Riemannian optimization on a fixed-rank manifold. However, a drawback of the known approaches is that the rank parameter has to be fixed a priori. In this paper, we consider the optimization problem on the set of bounded-rank matrices. We propose a Riemannian rank-adaptive method, which consists of fixed-rank optimization, rank increase step and rank reduction step. We explore its performance applied to the low-rank matrix completion problem. Numerical experiments on synthetic and real-world datasets illustrate that the proposed rank-adaptive method compares favorably with state-of-the-art algorithms. In addition, it shows that one can incorporate each aspect of this rank-adaptive framework separately into existing algorithms for the purpose of improving performance.
Mars’ plasma system. Scientific potential of coordinated multipoint missions: “The next generation”
Authors: Sánchez-Cano Beatriz , Lester Mark , Andrews David J. , Opgenoorth Hermann , Lillis Robert , Leblanc François , Fowler Christopher M. , Fang Xiaohua , Vaisberg Oleg , Mayyasi Majd , Holmberg Mika , Guo Jingnan , Hamrin Maria , Mazelle Christian , Peter Kerstin , Pätzold Martin , Stergiopoulou Katerina , Goetz Charlotte , Ermakov Vladimir Nikolaevich , Shuvalov Sergei , Wild James A. , Blelly Pierre-Louis , Mendillo Michael , Bertucci Cesar , Cartacci Marco , Orosei Roberto , Chu Feng , Kopf Andrew J. , Girazian Zachary , Roman Michael T. 
Published: November 2021

AbstractThe objective of this White Paper, submitted to ESA’s Voyage 2050 call, is to get a more holistic knowledge of the dynamics of the Martian plasma system, from its surface up to the undisturbed solar wind outside of the induced magnetosphere. This can only be achieved with coordinated multi-point observations with high temporal resolution as they have the scientific potential to track the whole dynamics of the system (from small to large scales), and they constitute the next generation of the exploration of Mars analogous to what happened at Earth a few decades ago. This White Paper discusses the key science questions that are still open at Mars and how they could be addressed with coordinated multipoint missions. The main science questions are: (i) How does solar wind driving impact the dynamics of the magnetosphere and ionosphere? (ii) What is the structure and nature of the tail of Mars’ magnetosphere at all scales? (iii) How does the lower atmosphere couple to the upper atmosphere? (iv) Why should we have a permanent in-situ Space Weather monitor at Mars? Each science question is devoted to a specific plasma region, and includes several specific scientific objectives to study in the coming decades. In addition, two mission concepts are also proposed based on coordinated multi-point science from a constellation of orbiting and ground-based platforms, which focus on understanding and solving the current science gaps.
Dimensional Latent Structure of Callous-Unemotional Traits in German Adolescents: Results from Taxometric Analyses
Authors: Kliem Sören , Krieg Yvonne , Klatt Thimna , Baier Dirk 
Published: November 2021

AbstractA large amount of research has addressed the issue of the latent status of psychiatric disorders and related phenomena. We used a new taxometric approach developed by Ruscio to examine the latent status of callous-unemotional (CU) traits in a large representative study of German ninth graders (N = 3,878). Rather than estimating a putative taxon base rate and using that estimate to generate the taxon comparative data, we estimated CCFI profiles with each base rate estimate between 2.5% and 97.5% in increments of 2.5%. Results of different indicator sets clearly suggested a dimensional solution. This finding is consistent with different studies showing the dimensionality of psychopathy in adolescents. In summary, the results of this study point to the need for critical reflection in defining a high-risk-group in the context of CU traits. However, further studies are necessary to substantiate this result in different samples using different measurement approaches.
End Stage Kidney Disease in Non-citizen Patients: Epidemiology, Treatment, and an Update to Policy in Illinois
Authors: Lange-Maia Brittney S. , Johnson Tricia J. , Gely Yumiko I. , Ansell David A. , Cmunt J. Kevin , Lynch Elizabeth B. 
Published: November 2021

AbstractEnd-stage kidney disease (ESKD) is common in the U.S. There is no cure, and survival requires either dialysis or kidney transplant. Medicare provides coverage for most ESKD patients in the U.S., though non-citizens are excluded from most current policies providing standard ESKD care, especially regarding kidney transplants. Despite being eligible to be organ donors, non-citizens often have few avenues to be organ recipients—a major equity problem. Overall, transplants are cost-saving compared to dialysis, and non-citizens have comparable outcomes to the general population. We reviewed the literature regarding the vastly different policies across the U.S., with a focus on current Illinois policy, including updates regarding Illinois legislation which passed in 2014 providing non-citizens to receive coverage for transplants. Unfortunately, despite legislation providing avenues for transplants, funds were not allocated, and the bill has not had the impact that was expected when initially passed. We outline opportunities for improving current policies.