bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Gestational Diabetes Mellitus
Authors: Begum Zinat , Banu Dewan Shahida , Shanta Shaila Sharmeen , Islam Shitil Ibna 
Published: June 2021

Objective: The present study was undertaken to determine the risk factors for Gestational Diabetes Mellitus (GDM) presented at Bangladesh Institute of Research in Diabetes, Endocrine & Metabolic Disorders (BIRDEM).
Materials & methods: The present case-control study was conducted at BIRDEM Hospital, Dhaka over a period of 6 months from July to December 2011. A total of 100 pregnant women (20 cases and 80 controls) were consecutively enrolled in the study. Pregnant women who developed diabetes at their 3rd trimester were cases (n = 20), while pregnant women free from diabetes at their 3rd trimester were controls (n = 80). The diagnosis of GDM was made using a two-step approach. Pregnant women were initially screened by measuring the plasma glucose concentrations 1 hour after a 50 gram of oral glucose challenge. A diagnostic oral glucose tolerance test was performed on the subset of women whose plasma glucose concentrations exceded the threshold value for glucose (> 140 mg/dl).
Result: The study showed that older patients (≥ 25 years) were predominant in both case and control groups. The groups were almost comparable in terms of socioeconomic status and occupation. The distribution of gestational age was also similar between groups (33.1 ± 6.3 vs. 34.2 ± 3.9 years, p = 0.476). Majority (85%) of the cases had family history of diabetes (p < 0.001). Thirty five percent of cases were nulipara and 65% multipara compared to 51.3% and 48.7% respectively of the control (p = 0.076). No significant difference was observed between the groups in terms of preterm labour and PROM (p = 0.690 and 0.220 respectively). Forty percent of cases had past history of GDM compared to 3.8% of controls (p < 0.001). The fasting plasma glucose and plasma glucose 2 hrs after 75 g of glucose ingestion were significantly higher in pregnant women having GDM than those in normal pregnant women (8.3 ± 3.1 vs. 4.1 ± 0.5 mmol/L, p < 0.001;12.9 ± 4.8 vs. 5.9 ± 1.2 mmol/L, p < 0.001 respectively).
Conclusion: The study concluded that none of the sociodemographic characteristics like age, socioeconomic status and occupation was found to be associated with GDM. However, pregnant women with family history of diabetes are at risk of developing GDM significantly more than those without GDM. Multipara tend to develop GDM more frequently than the primipara does. Past incidence of GDM increases the risk of GDM in the subsequent pregnancy.
Ibrahim Card Med J 2015; 5 (1&2): 49-53
Iatrogenic Dissection of Left Main-Stem during Primary PCI for Inferior STEMI: A Catastrophic Complication
Authors: Kabir CM Shaheen , Ali M Liaquat , Khan Saidur Rahman , Chowdhury Mashhud Zia , Haq M Maksumul 
Published: June 2021

Coronary artery dissection is a rare but well-recognized complication of coronary angiography with high morbidity and mortality rate. We present the case of a 54-year-old male who experienced iatrogenic left main-stem (LMS) dissection during transradial coronary angiography for inferior STEMI. The patient was successfully treated by prompt bail-out stenting. Intracoronary stenting is of value in stabilising the patients before emergency bypass surgery and can save lives in LMS complications.
Ibrahim Card Med J 2015; 5 (1&2): 67-71
Revisão bibliográfica e análises de visualizações sobre Kingsleya attenboroughi Pinheiro & Santana, 2016 (Crustacea: Decapoda: Brachyura: Pseudothelphusidae)
Authors: Sampaio Raimundo Samuel Leite , Lima Junior Fernandes de , Fernandes Júnior Francisco Ilosmar , Oliveira Maraiza Gregorio de , Teixeira Pedro Hudson Rodrigues , Correia Dennis Bezerra , Oliveira João Paulo Camilo de , Costa Maria Haiele Nogueira da , Rocha Maria Ivaneide , Muniz José Iago , Pereira Ginna Gonçalves , Sampaio Nayane Kely Silva 
Published: June 2021

Kingsleya attenboroughi, conhecido popularmente como “Guajá”, é uma espécie de caranguejo de água doce, endêmica da Chapada do Araripe- Ceará, Brasil (predominância situada no distrito de Arajara- Município de Barbalha), região caracterizada com inúmeras fontes de água doce, e assim favorecendo condições ideais para a sobrevivência de K. attenboroughi na localidade. Esta pesquisa consiste em um levantamento de dados sobre a espécie, e diferentes bases científicas foram analisadas: Google acadêmico®, ScienceDirect®, Web of sciences®, e Pubmed® para obter as informações. K. attenboroughi difere principalmente de suas congêneres por apresentar características próprias, como uma placa apical curta no primeiro gonópode. Poucos trabalhos foram relatados até o presente momento. Sua ecologia preocupa estudiosos uma vez que esta sobre constante ameaça de extinção. Desta forma, incentivos e pesquisas vem crescendo nesta região para evitar o colapso da biodiversidade.
One-Step Preparation of Nitrogen-Doped Graphene Quantum Dots With Anodic Electrochemiluminescence for Sensitive Detection of Hydrogen Peroxide and Glucose
Authors: Yanyan Zheng , Lin Jing , Xie Liuhong , Tang Hongliang , Wang Kailong , Liu Jiyang 
Published: June 2021

Simple and efficient synthesis of graphene quantum dots (GQDs) with anodic electrochemiluminescence (ECL) remains a great challenge. Herein, we present an anodic ECL-sensing platform based on nitrogen-doped GQDs (N-GQDs), which enables sensitive detection of hydrogen peroxide (H2O2) and glucose. N-GQDs are easily prepared using one-step molecular fusion between carbon precursor and a dopant in an alkaline hydrothermal process. The synthesis is simple, green, and has high production yield. The as-prepared N-GQDs exhibit a single graphene-layered structure, uniform size, and good crystalline. In the presence of H2O2, N-GQDs possess high anodic ECL activity owing to the functional hydrazide groups. With N-GQDs being ECL probes, sensitive detection of H2O2 in the range of 0.3–100.0 μM with a limit of detection or LOD of 63 nM is achieved. As the oxidation of glucose catalyzed by glucose oxidase (GOx) produces H2O2, sensitive detection of glucose is also realized in the range of 0.7–90.0 μM (LOD of 96 nM).
The Oxidative Response of Human Monocytes to Surface Modified Commercially Pure Titanium
Authors: De Poi Robert P. , Kowolik Michael , Oshida Yoshiki , El Kholy Karim 
Published: June 2021

Cellular responses to implanted biomaterials are key to understanding osseointegration. The aim of this investigation was to determine the in vitro priming and activation of the respiratory burst activity of monocytes in response to surface-modified titanium. Human peripheral blood monocytes of healthy blood donors were separated, then incubated with surface-modified grade 2 commercially pure titanium (CPT) disks with a range of known surface energies and surface roughness for 30- or 60-min. Secondary stimulation by phorbol 12-myrisate 13-acetate (PMA) following the priming phase, and luminol-enhanced-chemiluminescence (LCL) was used to monitor oxygen-dependent activity. Comparison among groups was made by incubation time using one-way ANOVA. One sample from each group for each phase of the experiment was viewed under scanning electron microscopy (SEM) and qualitative comparisons made. The results indicate that titanium is capable of priming peripheral blood monocytes following 60-min incubation. In contrast, 30 min incubation time lead to reduced LCL on secondary stimulation as compared to cells alone. At both time intervals, the disk with the lowest surface energy produced significantly less LCL compared to other samples. SEM examination revealed differences in surface morphology at different time points but not between differently surface-modified disks. These results are consistent with the hypothesis that the titanium surface characteristics influenced the monocyte activity, which may be important in regulating the healing response to these materials.
Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
Authors: Aguilera Jose , Vicente-Manzanares Miguel , de Gálvez María Victoria , Herrera-Ceballos Enrique , Rodríguez-Luna Azahara , González Salvador 
Published: June 2021

Background: Novel approaches to photoprotection must go beyond classical MED measurements, as discoveries on the effect of UV radiation on skin paints a more complex and multi-pronged scenario with multitude of skin cell types involved. Of these, photoimmunoprotection emerges as a crucial factor that protects against skin cancer and photoaging. A novel immune parameter is enabled by the precise knowledge of the wavelength and dose of solar radiation that induces photoimmunosupression. Natural substances, that can play different roles in photoprotection as antioxidant, immune regulation, and DNA protection as well as its possible ability as sunscreen are the new goals in cosmetic industry.Objective: To analyze the effect of a specific natural extract from Polypodium leucotomos (PLE, Fernblock®), as part of topical sunscreen formulations to protect from photoimmunosuppression, as well as other deleterious biological effects of UV radiation.Methods: The possible sunscreen effect of PLE was analyzed by including 1% (w/w) PLE in four different galenic formulations containing different combinations of UVB and UVA organic and mineral filters. In vitro sun protection factor (SPF), UVA protection factor (UVA-PF), contact hypersensitivity factor (CHS), and human immunoprotection factor (HIF) were estimated following the same protocol as ISO 24443:2012 for in vitro UVA-PF determination.Results: PLE-containing formulations significantly reduced UV radiation reaching to skin. Combination of UVB and UVA filters with PLE increased SPF and UVAPF significantly. PLE also increased UV immune protection, by elevating the contact hypersensitivity factor and the human immunoprotective factor of the sunscreen formulations.Conclusion: This study confirms the double role of PLE in photoprotection. Together to the biological activity shown in previous works, the UV absorption properties of PLE confers a booster effect when it is supplemented in topical sunscreens increasing the protection not only at level of erythema and permanent pigment darkening but also against two photoimmunoprotection factors.
Association Between Atopic Keratoconjunctivitis and the Risk of Recurrent Corneal Erosion
Authors: Jan Ren-Long , Weng Shih-Feng , Wang Jhi-Joung , Tseng Sung-Huei , Chang Yuh-Shin 
Published: June 2021

Purpose: To investigate the risk of recurrent corneal erosion (RCE) in patients with atopic keratoconjunctivitis (AKC).Methods: This national, retrospective, matched cohort study enrolled 184,166 newly-diagnosed AKC patients, selected from the Taiwan National Health Insurance Research Database and identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 372.05. The control group comprised 184,166 non-AKC patients matched by age, sex, and potential comorbidities and they were selected from the Taiwan Longitudinal Health Insurance Database, 2000. Information from patients was gathered from 1 January 2004 to 31 December 2011, and both groups were traced from the index date until December 2013. The incidence and risk of RCE (ICD-9-CM code 361.42) was compared between the groups. The adjusted hazard ratio (HR) for RCE was obtained by a Cox proportional hazard regression analysis. The Kaplan–Meier analysis was performed to calculate the cumulative incidence of RCE.Results: In total, 564 AKC patients and 406 non-AKC controls developed RCE during the follow-up span. The incidence of RCE was 1.45 times higher in AKC patients than in controls (95% confidence interval [CI] = 1.27–1.64; P &lt; 0.0001). After adjusting for potential confounders, including diabetes mellitus, keratoconjunctivitis sicca, corneal transplantation, ocular blunt trauma, corneal dystrophy, and band keratopathy, AKC patients were 1.36 times more likely to develop RCE than controls (adjusted HR, 1.36; 95% CI = 1.19–1.54; p &lt; 0.05).Conclusions: AKC Patients had an increased risk of developing RCE and should be informed of this risk.
Bereitschaftspotential in Multiple System Atrophy
Authors: Yang Yi-Chien , Chang Fang-Tzu , Chen Jui-Cheng , Tsai Chon-Haw , Lin Fu-Yu , Lu Ming-Kuei 
Published: June 2021

Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder manifesting as parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is categorized into MSA with predominant parkinsonism (MSA-P) and into MSA with predominant cerebellar ataxia (MSA-C). The pathophysiology of motor control circuitry involvement in MSA subtype is unclear. Bereitschaftspotential (BP) is a feasible clinical tool to measure electroencephalographic activity prior to volitional motions. We recorded BP in patients with MSA-P and MSA-C to investigate their motor cortical preparation and activation for volitional movement.Methods: We included eight patients with MSA-P, eight patients with MSA-C, and eight age-matched healthy controls. BP was recorded during self-paced rapid wrist extension movements. The electroencephalographic epochs were time-locked to the electromyography onset of the voluntary wrist movements. The three groups were compared with respect to the mean amplitudes of early (1,500–500 ms before movement onset) and late (500–0 ms before movement onset) BP.Results: Mean early BP amplitude was non-significantly different between the three groups. Mean late BP amplitude in the two patient groups was significantly reduced in the parietal area contralateral to the movement side compared with that in the healthy control group. In addition, the late BP of the MSA-C group but not the MSA-P group was significantly reduced at the central parietal area compared with that of the healthy control group.Conclusions: Our findings suggest that patients with MSA exhibit motor cortical dysfunction in voluntary movement preparation and activation. The dysfunction can be practicably evaluated using late BP, which represents the cerebello-dentato-thalamo-cortical pathway.
Brainstem Involvement in Amyotrophic Lateral Sclerosis: A Combined Structural and Diffusion Tensor MRI Analysis
Authors: Li Haining , Zhang Qiuli , Duan Qianqian , Jin Jiaoting , Hu Fangfang , Dang Jingxia , Zhang Ming 
Published: June 2021

IntroductionThe brainstem is an important component in the pathology of amyotrophic lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural changes in ALS patients, few studies have investigated structural alterations in the brainstem. Herein, we compared the brainstem structure between patients with ALS and healthy controls.MethodsA total of 33 patients with ALS and 33 healthy controls were recruited in this study. T1-weighted and diffusion tensor imaging (DTI) were acquired on a 3 Tesla magnetic resonance imaging (3T MRI) scanner. Volumetric and vertex-wised approaches were implemented to assess the differences in the brainstem’s morphological features between the two groups. An atlas-based region of interest (ROI) analysis was performed to compare the white matter integrity of the brainstem between the two groups. Additionally, a correlation analysis was used to evaluate the relationship between ALS clinical characteristics and structural features.ResultsVolumetric analyses showed no significant difference in the subregion volume of the brainstem between ALS patients and healthy controls. In the shape analyses, ALS patients had a local abnormal surface contraction in the ventral medulla oblongata and ventral pons. Compared with healthy controls, ALS patients showed significantly lower fractional anisotropy (FA) in the left corticospinal tract (CST) and bilateral frontopontine tracts (FPT) at the brainstem level, and higher radial diffusivity (RD) in bilateral CST and left FPT at the brainstem level by ROI analysis in DTI. Correlation analysis showed that disease severity was positively associated with FA in left CST and left FPT.ConclusionThese findings suggest that the brainstem in ALS suffers atrophy, and degenerative processes in the brainstem may reflect disease severity in ALS. These findings may be helpful for further understanding of potential neural mechanisms in ALS.
Comparison of Clinical Efficacy of Alectinib Versus Crizotinib in ALK-Positive Non-Small Cell Lung Cancer: A Meta-Analysis
Authors: Tang Hao , Jin Longyu , Zhang Zhang , Jiang Zhibin , Malik Zeeshan 
Published: June 2021

ObjectiveTo systematically evaluate the efficacy and safety of alectinib versus crizotinib in the treatment of anaplastic lymphoma kinase (ALK) positive non-small-cell lung cancer.MethodsStudies about the efficacy of alectinib versus crizotinib in the treatment of ALK-positive non-small cell lung cancer were searched in PubMed, Scopus, Embase and the Cocharane Library from inception to February 15, 2020. Two reviewers independently screened these studies, extracted the data, assessed the risk of bias in the included studies by using the Cochrane risk assessment tool, and then used review manager 5.3 software for meta-analysis.ResultsThree studies comprising a total of 697 patients with ALK-positive non-small cell lung cancer were included, 380 in the alectinib group and 317 in the crizotinib group. The dose of alectinib (300 mg) in J-ALEX were lower than the approved dose (600 mg), however the crizotinib group in all three studies received the recommended dose (250 mg). Performance bias was high in all three studies whereas, and the attrition bias was high in two studies (Toyoaki Hida 2017 and Solange peters 2017). The results of meta-analysis showed that: the overall response rate [OR = 2.07, 95% CI (1.41, 3.06), P = 0.0002], the progression free survival [HR = 0.34, 95% CI (0.21, 0.55), P &lt;0.0001], the partial response [OR = 1.71, 95% CI (1.19, 2.46), P = 0.003], P = 0.001], in alectinib group were higher than that of crizotinib group. Though the total number of events in complete response and the disease control rate were more in alectinib group than that of crizotinib group, the meta-analysis results shows no significant differences between two drugs in the disease control rate [OR = 2.24, 95% CI (0.56, 8.88), P = 0.25], the complete response [OR = 1.82, 95% CI (0.75, 4.45), P = 0.19]. In addition, the number of events in the stable disease [OR = 0.45, 95% CI (0.28, O.74), P = 0.001], and the adverse events [OR = 0.50, 95% CI (0.23, 0.81), P = &lt;0.0001] in alectinib group were lower than that of crizotinib group.ConclusionAlectinib in terms of overall response rate, progression-free survival and partial response is superior to crizotinib in the treatment of ALK-positive non-small cell lung cancer and is well tolerated. Compared with crizotinib, alectinib is more effective than crizotinib and has a lower incidence of total adverse reactions. Meta-analysis results confirm the strong base for alectinib as a first-line treatment for ALK-positive NSCLC.
Discovery of New Potent anti-MERS CoV Fusion Inhibitors
Authors: Kandeel Mahmoud , Yamamoto Mizuki , Park Byoung Kwon , Al-Taher Abdulla , Watanabe Aya , Gohda Jin , Kawaguchi Yasushi , Oh-hashi Kentaro , Kwon Hyung-Joo , Inoue Jun-ichiro 
Published: June 2021

Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its HR1 binding site. We designed eleven peptides with stronger estimated HR1 binding affinities than the wild-type peptide to prevent viral fusion with the cell membrane. Eight peptides showed strong inhibition of spike-mediated MERS-CoV cell-cell fusion with IC50 values in the nanomolar range (0.25–2.3 µM). Peptides #4–6 inhibited 95–98.3% of MERS-CoV plaque formation. Notably, peptide four showed strong inhibition of MERS-CoV plaques formation with EC50 = 0.302 µM. All peptides demonstrated safe profiles without cytotoxicity up to a concentration of 10 μM, and this cellular safety, combined with their anti-MERS-CoV antiviral activity, indicate all peptides can be regarded as potential promising antiviral agents.
Implementasi ABSS Accounting Pada Laporan Keuangan CV One Solution Media
Authors: Lesmana Hendra , Erawati Wati , Mubarok Husni , Suryanti Ery 
Published: June 2021

Laporan keuangan yang digunakan pada CV. One Solution Media masih dilakukan secara manual yaitu membuat laporan keuangan dengan mencatat pembukuan di kertas atau buku sehingga perusahaan sering kehilangan bukti transaksi dan perhitungan maupun pencatatan yang belum sesuai standar akuntansi membuat jumlah harta, modal maupun utang yang ada pada perusahaan tidak tampak jelas, serta laporan yang dihasilkan tidak lengkap, tidak ada laporan neraca dan perubahan modal perusahaan ini juga kurang ketat dalam mengelola bukti transaksi, sehingga pencatatan laporan keuangan secara manual dianggap kurang efektif. Sehingga perusahaan membutuhkan sebuah sistem informasi akuntansi untuk menciptakan laporan keuangan yang lengkap, rapi, tersaji tepat waktu, dan sesuai standar akuntansi. Sistem pencatatan akuntansi Berbasis Kas (Cash Basis), dan Sistem pencatatan persediaan menggunakan Metode Perpetual. Aplikasi yang di gunakan dalam penelitian ini yaitu ABSS Accounting. Penelitian diawali dengan pengelolaan data transaksi secara manual dan juga terkomputerisasi, kemudian dilakukan analisis untuk menemukan suatu perbedaan. Hasil dari penelitian ini menunjukkan bahwa laporan keuangan yang dihasilkan dari pencatatan secara manual maupun pencatatan dengan aplikasi ABSS Accounting sesuai dengan standar akuntansi, namun untuk pembuatan laporan akuntansi menggunakan ABSS Accounting lebih cepat jika dibandingkan dengan pencatatan akuntansi secara manual dan resiko mengalami kesalahan perhitungan lebih kecil. Tujuan dari penelitian adalah menciptakan laporan keuangan yang berkualitas bagi perusahaan, efektif, efisien, dan sesuai dengan standar akuntansi. Sehingga bermanfaat bagi perusahaan dalam pengendalian internal serta penunjang dalam pengambilan keputasan.
Pengaruh Regulasi Digital Cryptocurrency Model Bitcoin Terhadap Sistem Pembayaran Pada UMKM
Authors: Manurung Ria , Paath David Kristian 
Published: June 2021

Transaksi pembayaran secara online tak hanya menggunakan nominal sejumlah uang, tetapi menggunakan alternatif metode pembayaran dengan menggunakan uang virtual atau disebut dengan bitcoin. Tujuan penelitian untuk menganalisis dan mengetahui pengaruh regulasi digital Cryptocurrency terhadap sistem pembayaran pada Usaha Mikro Kecil dan Menengah (UMKM), mengetahui seberapa banyak UMKM yang pernah menggunakan bitcoin, sejauh mana perkembangan dari bitcoin tersebut. Penelitian menggunakan metode kualitatif dengan data primer diperoleh dari penyebaran kuisioner dan data sekunder yang terkait dengan penelitian melalui buku, jurnal, data kementerian keuangan dan Bank Indonesia. Penelitian dilakukan di Kabupaten Banyumas dengan menggunakan sampel sebanyak 250 responden yang terdiri dari masyarakat pengguna mata uang virtual bitcoin baik UMKM maupun non UMKM. Pemilihan sampel melalui metode non probability sampling yaitu metode purposive sampling serta data dianalisis menggunakan analisis regresi linear berganda dengan alat bantu aplikasi SPSS. Variabel yang digunakan pada penelitian yaitu ketetapan Bank Indonesia, keamanan sistem, dan peraturan otoritas jasa keuangan sebagai variabel X sedangkan variabel Y adalah sistem pembayaran pada UMKM. Hasil analisis masing-masing koefisien regresi yakni b1 = -0,021; b2 = 0,043; b3 = 0,10. Kesimpulan penelitian yaitu regulasi penggunaan digital cryptocurrency memiliki pengaruh signifikansi yang relatif kecil terhadap sistem pembayaran pada UMKM di kota Purwokerto. Penggunaan bitcoin mengalami peningkatan walaupun belum ada aturan yang berlaku di Indonesia khususnya daerah Banyumas.