bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplemental findings of the 2019 National Blood Collection and Utilization Survey
Authors: Mowla Sanjida J. , Sapiano Mathew R. P. , Jones Jefferson M. , Berger James J. , Basavaraju Sridhar V. 
Published: August 2021

AbstractIntroductionSupplemental data from the 2019 National Blood Collection and Utilization Survey (NBCUS) are presented and include findings on donor characteristics, autologous and directed donations and transfusions, platelets (PLTs), plasma and granulocyte transfusions, pediatric transfusions, transfusion‐associated adverse events, cost of blood units, hospital policies and practices, and implementation of blood safety measures, including pathogen reduction technology (PRT).MethodsNational estimates were produced using weighting and imputation methods for a number of donors, donations, donor deferrals, autologous and directed donations and transfusions, PLT and plasma collections and transfusions, a number of crossmatch procedures, a number of units irradiated and leukoreduced, pediatric transfusions, and transfusion‐associated adverse events.ResultsBetween 2017 and 2019, there was a slight decrease in successful donations by 1.1%. Donations by persons aged 16–18 decreased by 10.1% while donations among donors >65 years increased by 10.5%. From 2017 to 2019, the median price paid for blood components by hospitals for leukoreduced red blood cell units, leukoreduced apheresis PLT units, and for fresh frozen plasma units continued to decrease. The rate of life‐threatening transfusion‐related adverse reactions continued to decrease. Most whole blood/red blood cell units (97%) and PLT units (97%) were leukoreduced.ConclusionBlood donations decreased between 2017 and 2019. Donations from younger donors continued to decline while donations among older donors have steadily increased. Prices paid for blood products by hospitals decreased. Implementation of PRT among blood centers and hospitals is slowly expanding.
Interobserver reliability of Feline Dermatitis Extent and Severity Index (FEDESI) and Scoring Feline Allergic Dermatitis (SCORFAD) and the relationship between lesion scores and pruritus
Authors: Brame Bailey E. , Canning Peter , Morris Daniel O. , Drobatz Kenneth J. , Rook Kathryn , Cain Christine L. 
Published: August 2021

BackgroundFeline Dermatitis Extent and Severity Index (FEDESI) and Scoring Feline Allergic Dermatitis (SCORFAD) are scales used to assess lesion severity in cats with allergic dermatitis. Interobserver reliability has not been assessed for either.Hypothesis and objectivesTo determine interobserver reliability for FEDESI and SCORFAD, and the relationship between lesion scores and pruritus.AnimalsThirty‐eight cats presenting for pruritus.Methods and materialsEach cat’s lesions were scored by two observers at each visit using both FEDESI and SCORFAD (n = 117 paired observations). Spearman’s rho was calculated to assess correlation between scales and between each scale and the owner‐reported pruritus Visual Analog Scale (pVAS). Concordance correlation coefficients were calculated between observers for each scale, and Bland–Altman plots were used to visually represent the relationship between paired scores.ResultsFEDESI and SCORFAD were strongly positively correlated with one another (rho = 0.84, P < 0.001). Each scale showed fair correlation with pVAS (rho = 0.42, P < 0.001; rho = 0.38, P < 0.001, respectively). There was good concordance between observers for both scales, with a correlation coefficient of 0.77 for FEDESI and 0.80 for SCORFAD [intraclass correlation coefficient (ICC) 95%, confidence interval (CI) 0.69–0.83; ICC 95%, CI 0.72–0.86, respectively]. Median lesion score was low (FEDESI 20; SCORFAD 4), which may improve interobserver reliability.Conclusions and clinical importanceThere is good interobserver reliability for both FEDESI and SCORFAD. FEDESI and SCORFAD are positively correlated with one another and with pVAS. These findings support use of both scales in clinical research and assessment.
A Development Strategy for Structural Health Monitoring Applications
Authors: Cawley Peter 
Published: August 2021

Abstract
Permanently installed structural health monitoring (SHM) systems are now a viable alternative to traditional periodic inspection (nondestructive testing (NDT)). However, their industrial use is limited, and this article reviews the steps required in developing practical SHM systems. The transducers used in SHM are fixed in location, whereas in NDT, they are generally scanned. The aim is to reach similar performance with high temporal frequency, low spatial frequency SHM data to that achievable with conventional high spatial frequency, and low temporal frequency NDT inspections. It is shown that this can be done via change tracking algorithms such as the generalized likelihood ratio (GLR), but this depends on the input data being normally distributed, which can only be achieved if signal changes due to variations in the operating conditions are satisfactorily compensated; there has been much recent progress on this topic, and this is reviewed. Since SHM systems can generate large volumes of data, it is essential to convert the data to actionable information, and this step must be addressed in the SHM system design. It is also essential to validate the performance of installed SHM systems, and a methodology analogous to the model-assisted probability of detection (POD) (MAPOD) scheme used in NDT has been proposed. This uses measurements obtained from the SHM system installed on a typical undamaged structure to capture signal changes due to environmental and other effects and to superpose the signal due to damage growth obtained from finite element predictions. There is a substantial research agenda to support the wider adoption of SHM, and this is discussed in this study.
Moringa Oil With Pristine and Fluorinated Carbon Nanofibers as Additives for Lubrication
Authors: Nomede-Martyr Nadiege , Bercion Yves , Philippe Bilas , Dubois Marc , Joseph Henry , Philippe Thomas 
Published: August 2021

Abstract
This study focuses on the influence of local moringa oil on the performances of lubricants obtained from a blend of dodecane and pristine or fluorinated carbon nanofibers at ambient temperature. The friction experiments have been evaluated using a reciprocating ball on a plane tribometer. Moringa oil is used as a bio-additive in lubricant formulations. First, the addition of a small amount of moringa oil to dodecane allowed a reduction of about 50% of the base oil friction performances. Second, a comparative study on the friction properties of their blends with pristine carbon nanofibers (CNFs) and fluorinated ones (CF0.85) was investigated, based on which they were intended to be used as solid lubricant additives. An adsorption effect of fatty acid molecules is observed in CNFs particles unlike CF0.85. Whatever was the percentage of moringa oil added, more promising results were obtained with CF0.85. Physicochemical characterizations of the tribofilms evidence the good antiwear properties of the lubricants.
Mode Mixity in the Fracture Toughness Evaluation of Heat-Affected-Zone Material Using SEN(T) Experiment
Authors: Kalyanam S. , Hioe Y. , Wilkowski G. M. 
Published: August 2021

Abstract
Single-edge-notch-tension, SEN(T), specimens have been found to provide a good similitude for surface cracks in pipes, where a surface-cracked structure has lower constraint condition than single-edge notch bend, SEN(B) (bend-bars), and compact-tension, C(T) specimens. This lower constraint condition gives higher upper-shelf toughness values, and also a lower brittle-to-ductile transition temperature. Additionally, the SEN(T) specimen eliminates concern of material anisotropy since the crack growth direction in the SEN(T) specimen is the same as in a surface-cracked pipe. While the existing recommended and industrial practices for SEN(T) have been developed based on assumption of homogenous or monomaterial across the crack, their applicability for the evaluation of fracture toughness of the heat-affected zone (HAZ) were evaluated in this investigation. When conducting experiments on SEN(T) specimens with a prescribed notch/crack in the HAZ, the asymmetric deformation around the crack causes the occurrence of a combination of Mode-I (crack opening) and mode-II (crack in-plane shearing) behavior. The extent of this mode mixity is dependent on the relative difference between the material properties of the adjacent girth weld and pipe base metals, as well as the amount of crack growth in the experiment. This mode mixity affects the measurement of the crack-tip-opening-displacement (CTOD) and evaluation of fracture mechanics parameter, J. The CTOD-R curve depicts the change in toughness with crack growth, in a manner similar to the J–R curve methodology. Observations also show a mismatch in the length of the crack growth that is measured on the fracture surface, attributable to the material deformation differences across the two adjacent materials (weld and base metals). This paper discusses the experimental observations of Mode I and Mode II behavior seen in experiments conducted on SEN(T) specimens with a notch/crack in the HAZ and as the crack propagates through the weld/HAZ thickness. The paper addresses the issues related to and the changes needed to account for such behavior toward the development of recommended practices or standards for SEN(T) experiments of weld/HAZ. The effects of mode mixity in HAZ SEN(T) experiments is critical to the development of crack growth resistance, CTOD-R and J–R curves employed in engineering critical assessment (ECA) of pipelines.
Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships
Authors: Scheetz Marc H. , Pais Gwendolyn M. , Lodise Thomas P. , Tong Steven Y. C. , Davis Joshua S. , O’Donnell J. Nicholas , Liu Jiajun , Neely Michael , Prozialeck Walter C. , Lamar Peter C. , Rhodes Nathaniel J. , Holland Thomas , Avedissian Sean N. 
Published: August 2021

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (
n
= 48) and two prospective clinical studies (PROVIDE [
n
= 263] and CAMERA2 [
n
= 291]).
The fossilist and his engraver: Samuel Springsguth’s illustrations of James Parkinson’s Organic Remains
Authors: Lewis* Cherry 
Published: August 2021

ABSTRACT
James Parkinson was an apothecary surgeon, political activist, and paleontologist during the latter part of the long eighteenth century. He is most famous for his 1817 work, An Essay on the Shaking Palsy, in which he was the first to describe and define the symptoms of paralysis agitans, a condition now known as Parkinson’s disease. During his lifetime, however, he was internationally renowned for his three-volume study of fossils, Organic Remains of a Former World. Sales of this work continued for 25 years after Parkinson’s death, even though much of its scientific content had become redundant. This was due to the beauty and fidelity of its illustrations, although Samuel Springsguth, the illustrator and engraver, is never explicitly acknowledged in the work. By examining several extant fossils known to have been in Parkinson’s collection and illustrated in his works, it has been possible to gain some insight into the way that Parkinson and Springsguth worked together when illustrating these volumes.
Association between informal employment and mortality rate by welfare regime in Latin America and the Caribbean: an ecological study
Authors: Silva-Peñaherrera Michael , López-Ruiz María , Merino-Salazar Pamela , Gomez Garcia Antonio Ramon , Benavides Fernando G 
Published: August 2021

ObjectiveWe aimed to estimate the association between informal employment and mortality in Latin America and the Caribbean (LAC) by comparing welfare state regimes.DesignEcological study using time-series cross-sectional analysis of countries. Informality was estimated from household surveys by the Center for Distributive, Labor and Social Studies in collaboration with the World Bank, and the adult mortality rates for 2000–2016 were obtained from the WHO databases. Countries were grouped by welfare state regimes: state productivist, state protectionist and familialist. We calculated the compound annual growth rate for each country and performed linear regression between the informality and the adult mortality rates stratified by sex and welfare state regime.SettingSeventeen countries from LAC with available data on informality and adult mortality rates for 2000–2016.Primary outcome measureThe association between informality and mortality by welfare state regime.ResultsBetween 2000 and 2016, mortality rates decreased an average 1.3% per year and informal employment rates 0.5% per year. We found a significant positive association between informality and mortality rates (women: R2=0.48; men: R2=0.36). The association was stronger among the state regime countries (women: R2=0.58; men: R2=0.77), with no significant association among the familialist countries.ConclusionInformal employment negatively impacts population health, which is modified by welfare state regimes. Addressing informal employment could be an effective way to improve population health in LAC. However, linkage with public health and labour market agendas will be necessary.
Is the outcome of fitting hearing aids to adults affected by whether an audiogram-based prescription formula is individually applied? A systematic review protocol
Authors: Almufarrij Ibrahim , Dillon Harvey , Munro Kevin J 
Published: August 2021

IntroductionHearing aids are typically programmed using the individual’s audiometric thresholds. Developments in technology have resulted in a new category of direct-to-consumer devices, which are not programmed using the individual’s audiometric thresholds. This review aims to identify whether programming hearing aids using the individual’s audiogram-based prescription results in better outcomes for adults with hearing loss.Methods and analysisThe methods of this review are reported in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. On 23 August 2020, eight different databases were systematically searched without any restrictions: EMBASE, MEDLINE, PubMed, PsycINFO, Web of Science, Cochrane Library, Emcare and Academic Search Premier. To ensure that this review includes the most recent evidence, the searches will be repeated at the final write-up stage. The population of interest of this review will be adults with any degree or type of hearing loss. The studies should compare hearing aids programmed using an audiogram-based prescription (and verified in the real ear) with those not programmed on the basis of the individual’s audiogram. The primary outcome of interest is consumers’ listening preferences. Hearing-specific health-related quality of life, self-reported listening ability, speech intelligibility of words and sentences in quiet and noisy situations, sound quality ratings and adverse events are the secondary outcomes of interest. Both randomised and non-randomised controlled trials will be included. The quality of each individual study and the overall evidence will be assessed using Downs and Black’s checklist and the Grading of Recommendations, Assessment, Development and Evaluations tool, respectively.Ethics and disseminationWe will only retrieve and analyse data from published studies, so no ethical approval is required. The review findings will be published in a peer-reviewed journal and presented at scientific conferences.PROSPERO registration numberCRD42020197232.
Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper
Authors: Ranger Tom Alan , Burchardt Judith , Clift Ashley Kieran , Mei Winnie Xue , Coupland Carol , Tan Pui San , Dixon Sharon , Cardwell Christopher Robert , Hippisley-Cox Julia 
Published: August 2021

IntroductionHormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean that more women who survive cancer go on to experience menopausal symptoms. Understanding these relationships is important so that women and their clinicians can make informed decisions around the risks and benefits of HRT. This study’s primary aim is to determine the association between HRT use after cancer diagnosis and the risk of cancer-specific mortality. The secondary aims are to investigate the risks of HRT on subsequent cancer, all-cause mortality and CVD.Methods and analysisWe will conduct a population-based longitudinal cohort study of 18–79 year-old women diagnosed with cancer between 1998 and 2020, using the QResearch database. The main exposure is HRT use, categorised based on compound, dose and route of administration, and modelled as a time-varying covariate. Analysis of HRT use precancer and postcancer diagnosis will be conducted separately. The primary outcome is cancer-specific mortality, which will be stratified by cancer site. Secondary outcomes include subsequent cancer diagnosis, CVD (including venous thrombo-embolism) and all-cause mortality. Adjustment will be made for key confounders such as age, body mass index, ethnicity, deprivation index, comorbidities, and cancer grade, stage and treatment. Statistical analysis will include descriptive statistics and Cox proportional hazards models to calculate HRs and 95% CIs.Ethics and disseminationEthical approval for this project was obtained from the QResearch Scientific Committee (Ref: OX24, project title ‘Use of hormone replacement therapy and survival from cancer’). This project has been, and will continue to be, supported by patient and public involvement panels. We intend to the submit the findings for peer-reviewed publication in an academic journal and disseminate them to the public through Cancer Research UK.
SUpporting wellbeing through PEeR-Befriending (SUPERB) feasibility trial: fidelity of peer-befriending for people with aphasia
Authors: Behn Nicholas , Moss Becky , McVicker Sally , Roper Abi , Northcott Sarah , Marshall Jane , Thomas Shirley , Simpson Alan , Flood Chris , James Kirsty , Goldsmith Kimberley , Hilari Katerina 
Published: August 2021

ObjectiveTo evaluate systematically the fidelity of a peer-befriending intervention for people with aphasia.DesignSUpporting wellbeing through Peer-befriending (SUPERB) was a feasibility randomised controlled trial comparing usual care to usual care +peer-befriending. This paper reports on the fidelity of all intervention aspects (training and supervision of providers/befrienders; intervention visits) which was evaluated across all areas of the Behaviour Change Consortium framework.SettingCommunity.ParticipantsPeople with aphasia early poststroke and low levels of distress, randomised to the intervention arm of the trial (n=28); 10 peer-befrienders at least 1-year poststroke.InterventionPeer-befrienders were trained (4–6 hours); and received regular supervision (monthly group while actively befriending, and one-to-one as and when needed) in order to provide six 1-hour peer-befriending visits over 3 months.Main measuresMetrics included number and length of training, supervision sessions and visits. All training and supervision sessions and one (of six) visits per pair were rated against fidelity checklists and evaluated for inter-rater and intrarater reliability (Gwets AC1 agreement coefficient). Per-cent adherence to protocol was evaluated.ResultsAll peer-befrienders received 4–6 hours training over 2–3 days as intended. There were 25 group supervision sessions with a median number attended of 14 (IQR=8–18). Twenty-six participants agreed (92.8%) to the intervention and 21 (80.8%) received all six visits (median visit length 60 min). Adherence was high for training (91.7%–100%) and supervision (83%–100%) and moderate-to-high for befriending visits (66.7%–100%). Where calculable, inter-rater and intrarater reliability was high for training and supervision (Gwets AC1 >0.90) and moderate-to-high for intervention visits (Gwets AC1 0.44–1.0).ConclusionPlanning of fidelity processes at the outset of the trial and monitoring throughout was feasible and ensured good-to-high fidelity for this peer-befriending intervention. The results permit confidence in other findings from the SUPERB trial.Trial registration numberNCT02947776.
HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial
Authors: Bakker Noor Alida Maria , Rotman Jossie , van Beurden Marc , Zijlmans Henry J MAA , van Ruiten Maartje , Samuels Sanne , Nuijen Bastiaan , Beijnen Jos , De Visser Karin , Haanen John , Schumacher Ton , de Gruijl Tanja D , Jordanova Ekaterina S , Kenter Gemma G , van den Berg Joost H , van Trommel Nienke E 
Published: August 2021

BackgroundUsual vulvar intraepithelial neoplasia (uVIN) is a premalignancy caused by persistent infection with high-risk types of human papillomavirus (HPV), mainly type 16. Even though different treatment modalities are available (eg, surgical excision, laser evaporation or topical application of imiquimod), these treatments can be mutilating, patients often have recurrences and 2%–8% of patients develop vulvar carcinoma. Therefore, immunotherapeutic strategies targeting the pivotal oncogenic HPV proteins E6 and E7 are being explored to repress carcinogenesis.MethodIn this phase I/II clinical trial, 14 patients with HPV16+ uVIN were treated with a genetically enhanced DNA vaccine targeting E6 and E7. Safety, clinical responses and immunogenicity were assessed. Patients received four intradermal HPV-16 E6/E7 DNA tattoo vaccinations, with a 2-week interval, alternating between both upper legs. Biopsies of the uVIN lesions were taken at screening and +3 months after last vaccination. Digital photography of the vulva was performed at every check-up until 12 months of follow-up for measurement of the lesions. HPV16-specific T-cell responses were measured in blood over time in ex vivo reactivity assays.ResultsVaccinations were well tolerated, although one grade 3 suspected unexpected serious adverse reaction was observed. Clinical responses were observed in 6/14 (43%) patients, with 2 complete responses and 4 partial responses (PR). 5/14 patients showed HPV-specific T-cell responses in blood, measured in ex vivo reactivity assays. Notably, all five patients with HPV-specific T-cell responses had a clinical response.ConclusionsOur results indicate that HPV-16 E6/E7 DNA tattoo vaccination is a biologically active and safe treatment strategy in patients with uVIN, and suggest that T-cell reactivity against the HPV oncogenes is associated with clinical benefit.Trial registration numberNTR4607.