bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elastic, Mechanical and Thermophysical properties of Single-Phase Quaternary ScTiZrHf High-Entropy Alloy
Authors: Rai Sachin , Chaurasiya Navin , Yadawa Pramod K. 
Published: November 2021

Consequent to the interaction potential model, the high-order elastic constants at high entropy alloys in single-phase quaternary ScTiZrHf have been calculated at different temperatures. Elastic constants of second order (SOECs) helps to determine other ultrasonic parameters. With the help of SOECs other elastic moduli, bulk modulus, shear modulus, Young’s modulus, Pugh’s ratio, elastic stiffness constants and Poisson’s ratio are estimated at room temperature for elastic and mechanical characterization. The other ultrasonic parameters are calculated at room temperature for elastic and mechanical characterization. The temperature variation of ultrasonic velocities along the crystal's z-axis is evaluated using SOECs. The temperature variation of the average debye velocity and the thermal relaxation time (τ) are also estimated along this orientation axis. The ultrasonic properties correlated with elastic, thermal and mechanical properties which is temperature dependent is also discussed. The ultrasonic attenuation due to phonon – phonon (p-p) interactions is also calculated at different temperatures. In the study of ultrasonic attenuation such as a function of temperature, thermal conductivity appears to be main contributor and p- p interactions are the responsible reason of attenuation and found that the mechanical properties of the high entropy alloy ScTiZrHf are superior at room temperature.
Ko nipa Africa! – Teach about Africa! Challenging stereotypes about Africa
Authors: Kármán Marianna , Márföldi Nóra 
Published: November 2021

Abstract
Designed for three age groups, Ko Nipa Africa! – Teach about Africa! awareness-raising and sensitization education program is aimed at developing social competencies, especially empathy, social sensitivity, and tolerance in childhood. In addition, its main task is to transform the misconceptions and prejudices about Africa present in Hungary with active learning. The series of programs seeks to bring the diverse cultural, natural, and historical values of the African continent closer to the younger generation using the approach of global education, and the method, and tools of experiential pedagogy. Since the founding of the program series in 2012, it has been tested, implemented, and reworked in dozens of educational institutions, and several studies have demonstrated positive changes in students' thinking as the result of sensitization.
Psychedelic treatment for co-occurring alcohol misuse and post-traumatic stress symptoms among United States Special Operations Forces Veterans
Authors: Mangini Pratheek , Averill Lynnette A. , Davis Alan K. 
Published: November 2021

AbstractBackground&aimsSpecial Operations Forces Veterans (SOFV) have unique treatment needs stemming from multiple repeated forms of combat exposure resulting in a complex sequela of problems including alcohol misuse and post-traumatic stress symptoms. Current approved pharmacologic treatments for alcohol misuse and PTSD are lacking in adherence and efficacy, warranting novel treatment development. The current study examined the correlations between psychedelic treatment and changes in alcohol misuse among trauma exposed United States SOFV.MethodAn anonymous internet-based survey was conducted among SOFV who completed a specific psychedelic clinical program in Mexico. Retrospective questions probed alcohol use and post-traumatic stress symptoms during the 30-days before and 30-days after the psychedelic treatment. A total of 65 SOFV completed treatment and were eligible for contact. Of these, 51 (78%) completed the survey, and 27 (42%) reported alcohol misuse (≥4 on the AUDIT-C) in the 30 days prior to treatment and were included in analyses (Mean Age = 40; male = 96%; Caucasian/White = 96%).ResultsThere were significant and very large reductions in retrospective reports of alcohol use (P< 0.001;d= –2.4) and post-traumatic stress symptoms (P< 0.001;d= –2.8) and a significant and large increase in psychological flexibility (P< 0.001;d= –1.8), from before-to-after the psychedelic treatment. In the 30 days after treatment, 85% reduced their alcohol consumption to non-risky levels (33% abstinent; 52% non-risky drinking). Increases in psychological flexibility were strongly associated with reductions in alcohol use and post-traumatic stress symptoms (rs range 0.38–0.90; ps < 0.05).ConclusionRigorous longitudinal studies should be conducted to determine whether psychedelic-assisted therapy holds promise as an intervention in this population.
Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice
Authors: Hosoya Takuji , Uchida Shunya , Shibata Shigeru , Tomioka Naoko H. , Matsumoto Koji , Hosoyamada Makoto 
Published: November 2021

Significance Statement
Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI). However, the precise pathophysiologic mechanisms underlying EIAKI have yet to be elucidated. We investigated the cause of EIAKI and the therapeutic effect of xanthine oxidoreductase inhibitors by establishment of a high HPRT activity Urat1-Uox double knockout mouse. The onset of EIAKI associated with RHUC1 was related to increased excessive urinary urate excretion brought on by exercise, and inflammatory signals via NLRP3 inflammasome activation in the kidney. We showed xanthine oxidoreductase inhibitors (topiroxostat and allopurinol) to be effective for the treatment of EIAKI with RHUC1 in this mouse model.

Background
Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI). However, because there is no useful experimental RHUC1 animal model, the precise pathophysiologic mechanisms underlying EIAKI have yet to be elucidated. We established a high HPRT activity Urat1-Uox double knockout (DKO) mouse as a novel RHUC1 animal model for investigating the cause of EIAKI and the potential therapeutic effect of xanthine oxidoreductase inhibitors (XOIs).

Methods
The novel Urat1-Uox DKO mice were used in a forced swimming test as loading exercise to explore the onset mechanism of EIAKI and evaluate related purine metabolism and renal injury parameters.

Results

Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine and BUN as renal injury markers, and decreased creatinine clearance observed in a forced swimming test. In addition, Urat1-Uox DKO mice had increased NLRP3 inflammasome activity and downregulated levels of Na+-K+-ATPase protein in the kidney, as Western blot analysis showed. Finally, we demonstrated that topiroxostat and allopurinol, XOIs, improved renal injury and functional parameters of EIAKI.

Conclusions

Urat1-Uox DKO mice are a useful experimental animal model for human RHUC1. The pathogenic mechanism of EIAKI was found to be due to increased levels of IL-1β via NLRP3 inflammasome signaling and Na+-K+-ATPase dysfunction associated with excessive urinary urate excretion. In addition, XOIs appear to be a promising therapeutic agent for the treatment of EIAKI.
Emprendimiento en México: el antes y el después de la covid-19
Authors: Santamaria Velasco Carlos Alberto , Montañez Moya Gloria Silviana , Gutierrez Olvera Sandra 
Published: November 2021

La crisis sanitaria ocasionada por la covid-19 ha generado incertidumbre en la economía global y en todos los sectores; en particular a los emprendedores de mipymes que han sufrido consecuencias significativas. Este artículo se centra en una revisión de literatura sistemática con estudios relacionados con emprendimiento, crisis y oportunidades. En total se analizaron 30 artículos para identificar las percepciones y acciones que efectúan los emprendedores para hacerle frente a una crisis en América Latina, y especialmente en México. Además de abordar experiencias de emprendedo- res de México acerca de los impactos de la covid-19 en sus negocios.
Los resultados proveen una revisión de literatura sobre emprendimiento y crisis para contribuir a los desafíos que puedan deparar los emprendimientos pospandemia; además, se determina cómo los emprendedores han tenido que adaptarse a esta nueva situación.
Se logró identificar actitudes adoptadas bajo la crisis, características de los empren- dedores, capital social y humano, entre otros. Estos factores pueden ser considerados en las universidades y en los stakeholders con el objetivo de implementarlos en los programas de emprendimiento que ofertan sobre qué hacer cuando se presente una crisis en la empresa.
Este estudio provee una revisión de literatura sobre emprendimiento y crisis para contribuir a lo que pueden deparar los emprendimientos pospandemia; así como para proponer una línea de investigación futura en economías emergentes sobre el impacto de la covid-19 en los emprendedores.
Alkol ve madde kullanım bozukluğu tanılı hastalarda inflamasyon düzeyleri
Authors: KULU Müberra , ÖZSOY Filiz , DEMİR Bahadır 
Published: November 2021

Amaç: Bu çalışmada amaç; alkol kullanım bozukluğu (AKB) ve madde kullanım bozukluğu (MKB) tanısı konulan iki ayrı hasta grubunun inflamasyon belirteçlerini sağlıklı kontroller ve birbirleri ile karşılaştırarak incelemektir.
Gereç ve Yöntem: Çalışmamıza 159 kişi (100 kişi hasta grubu ve 59 kişi kontrol grubu olarak) alındı. Tüm katılımcıların demografik verileri bir form halinde yazıldı ve laboratuvar parametreleri tam kan sayımı ile değerlendirildi.
Bulgular: MKB tanılı hastaların; 24’ü (%48) esrar, 26’sı (%52) sentetik kannabinoid kullanıyordu. Her iki hasta grubunda da hemoglobin, hematokrit, RDW-standart sapma olarak değeri (RDW-SD), ortalama platelet hacmi (MPV) değeri sağlıklı kontrollerden yüksek idi. Platelet değeri AKB hastalarında diğer iki gruptan düşük iken, eritrosit değeri MKB hastalarında diğer iki gruptan yüksek idi.
Sonuç: Hem AMKB patofizyolojisinde bazı inflamatuvar parametrelerinin etkili olabileceği düşünülmüştür. Ayrıca bu parametrelerdeki değişikliklere bağlı olarak oluşabilecek spontan kanama, enfeksiyon hastalıklarına yatkınlık gibi komplikasyonlar da hem hastaların değerlendirilmeleri hem de tedavi planlamalarında göz önüne alınmalıdır.
Enrichment of aqueous solubility and dissolution profile of mesalamine: In vitro evaluation of solid dispersion
Authors: Pawar Anil Raosaheb , Mundhe Pralhad Vitthalrao , Deshmukh Vinayak  Kashinath , Pandhare Ramdas Bhanudas , Nandgude Tanaji Dilip 
Published: November 2021

The aim of the present study was to formulate solid dispersion (SD) of Mesalamine to enrich the aqueous solubility and dissolution rate. Mesalamine is used in the management of acute ulcerative colitis and for the prevention of relapse of active ulcerative colitis. In the present study, Solid dispersion of Mesalamine was prepared by Fusion and Solvent evaporation method with different polymers. SD’s were characterized by % practical yield, drug content, Solubility, FT-IR, PXRD (Powder X- ray diffractometry), SEM (Scanning electron microscopy), in vitro dissolution studies and Stability studies. The percent drug release of prepared solid dispersion of Mesalamine by fusion and solid dispersion method (FM47, FM67, SE47 and SE67) in 1:7 ratio was found 81.36±0.41, 86.29±0.64, 82.45±0.57and 87.25±1.14 respectively. The aqueous solubility and percent drug release of solid dispersion of Mesalamine by both methods was significantly increased. The PXRD demonstrated that there was a significant decrease in crystallinity of pure drug present in the solid dispersions, which resulted in an increased aqueous solubility and dissolution rate of Mesalamine.The significant increase in aqueous solubility and dissolution rate of Mesalamine was observed in solid dispersion as the crystallinity of the drug decreased, absence of aggregation and agglomeration, increased wetability and good dispersibility after addition of PEG 4000 and PEG 6000.
Conceptual issues of professional education of specialists in the "Environmental Protection Technologies"
Authors: Andrianova I.S. , Gerasimov O.I. , Kuryatnikov V.V. , Spivak A.Ya 
Published: November 2021

Composing the programs for the education of specialists in the field of environmental protection requires clear ideas about the concepts, place of basic disciplines and the main issues of the future specialty. Peculiarities of methodological aspects of description of levels and assessment of quality of education in terminology of competences and learning outcomes are considered. They consist in the predominance of competencies, that have a physical meaning and ensure the filling of the "core" of the educational program with physical principles, methods and models.
The study of polluting processes in natural objects requires knowledge of the physics of aerodisperse systems in connection with the solution of aerosol emissions into the atmosphere, knowledge of the physics of the dispersible silt-covered upcasts into the aquatic environment, knowledge and understanding of physical phenomena of heat and mass transfer processes in soil, as in the granular system, knowledge of the physics of external radiation, including sound, heat, electromagnetic, in particular, ionizing radiation, and their impact on the environment.
Peculiarities of the educational system of training specialists in the field of environmental protection take into account the tasks of systemic radioecology, among which the tasks of radiation monitoring are especially important. The conceptual approach to the study of radioecology is proposed not as a whole, mixing the laws of physics, chemistry and, for example, biology, but by individual branches, and systematically.
Genetic and Morphological Variability among the Isolates of Fusarium oxysporum f. sp. lentis causing Wilt of Lentil
Authors: Arya Anshul , Singh Sujata , Kushwaha K.P.S. , Bohra Yogita , Kushwaha Arun , Sharma Roopali 
Published: November 2021

Background: Lentil wilt is one of the most important diseases of lentil directly contributing to the yield losses of the crop. It is caused by Fusarium oxysporum f. sp. lentis which shows the great genetic and morphological diversity. Methods: Present investigation was conducted during 2017-2019 with 22 isolates of the pathogen, collected from lentil grown areas of Uttarakhand and Uttar Pradesh to explore genetic and morphological variability employing eight ISSR and five SSR primers. Result: The isolates showed huge morphological variability based on the color, pigmentation and shape of conidia. Study on molecular variability revealed the versatility in the genome of different isolates of pathogen. The diversity among the isolates of pathogens collected from Uttarakhand and Uttar Pradesh was also evident. Generated work on genetic and morphological variability and the population diversity among the different isolates of the pathogen impact on developing ideal disease management strategies.
Survey of Preservation and Conservation of Information Resources in Private University Libraries, South-west, Nigeria
Authors: Bashorun Musediq Tunji , Idogun-Omogbai Esther Kehinde , Muhammad Jamiu Oladele 
Published: November 2021

Background of study: Preservation and conservation of the cultural, social and technical context of our heritage are germane.
Purpose: The study examined the preservation and conservation of information resources in selected private university libraries in South-west Nigeria. Eight (8) selected private universities in South-west, Nigeria with the population consisted of one hundred thirty-seven respondents which comprised of library professionals and para-professionals.
Method: The study employed a survey research design and random sampling technique. Data collected with aids of semi- structured questionnaire and was analysed using frequency, mean and standard deviation with the aid of a Statistical Package for Social Sciences (IBM-SPSS) version 20.0
Results: The findings revealed that book becoming torn is the highest nature of deterioration followed by vandalisation, mutilation and brittle of print library materials. Moreover, the study revealed that digital preservation level of utilisation is low and is not extensively used in selected private university libraries.
Conclusion: The study concluded that preservation and conservation techniques are recognized in the selected university libraries, but the digital preservation techniques are not adequately used due to various constraints. One of the recommendations made was the provision of formal training for library staff on preservation and conservation of information resources.
A Compass to Guide Insights into TH17 Cellular Metabolism and Autoimmunity
Authors: Wilson Adrianna N. , Mosure Sarah A. , Solt Laura A. 
Published: November 2021

Abstract
T cells rapidly convert their cellular metabolic requirements upon activation, switching to a highly glycolytic program to satisfy their increasingly complex energy needs. Fundamental metabolic differences have been established for the development of Foxp3+ T regulatory (Treg) cells versus TH17 cells, alterations of which can drive disease. TH17 cell dysregulation is a driver of autoimmunity and chronic inflammation, contributing to pathogenesis in diseases such as multiple sclerosis. A recent paper published in Cell by Wagner, et al. combined scRNA-seq and metabolic mapping data to interrogate potential metabolic modulators of TH17 cell pathogenicity. This Compass to TH17 cell metabolism highlights the polyamine pathway as a critical regulator of TH17/Treg cell function, signifying its potential as a therapeutic target.
Discussion on Hundru fall as a knick point, Iharkhand, India
Authors: Sinha Malavika 
Published: November 2021

Subarnarekha River lies in the vicinity to the Ranchi mega lineament zone of Jharkhand State. This river links the Tamar Porapahar shear zone and North Singhbhum shear zone. The Hundru falls is the sudden and abrupt drop of elevation (longitudinal profile) of upstream of river Subarnarekha. The basic aim of this paper is to assess the Hundru falls as a perfect citation of an upstream knick point in Indian context. This paper covers the knick point formation of upstream of the Subarnarekha river. This upper catchment is more diversified in the terms of metamorphic and igneous rocks. This zone has crossed a long path with diversified lithospheric adjustment with epirogenic upliftment.
ANALISIS PENERAPAN PRINSIP ETIKA BISNIS ISLAM TERHADAP TRANSAKSI JUAL BELI PADA MARKETPLACE LAZADA
Authors: Rianti Rianti 
Published: November 2021

Business ethics is a character that is used to differentiate between a good and bad thing, right or wrong, should or should not, etc. and means a general principle that corrects someone to implement it in their behavior in terms of the business world. In today's era where technology has developed very rapidly, people can often understand in the business world about a business that has the main goal of getting very much profit. In economic law that continues to rely on little capital and also wants to get as much profit as possible, it is possible that business actors dominate business actors so that they do everything they can to get very large profits. Whereas in Islamic law, it has been explained how the ethics of doing business in sharia which have been exemplified by the Prophet Muhammad SAW. This study aims to analyze the suitability of the application of business ethics in online buying and selling transactions on Lazada Marketplace with sharia business ethics in accordance with the rules set by Islam. The method used in this study is a descriptive method to describe an object or subject as it is to present reality and have the characteristics of the object precisely studied. The results showed that Islamic business ethics have not been applied in the practice of buying and selling in online stores in Marketplace Lazada and the application of business ethics practices has not been in accordance with islamic business ethics principles.
Etika bisnis adalah karakter yang digunakan untuk membedakan antara hal yang baik dan buruk, benar atau salah, harus atau tidak, dll dan berarti prinsip umum yang mengoreksi seseorang untuk menerapkannya dalam perilaku mereka dalam dunia bisnis. Di era sekarang ini di mana teknologi berkembang sangat pesat, orang sering kali dapat memahami dalam dunia bisnis tentang sebuah bisnis yang memiliki tujuan utama untuk mendapatkan keuntungan yang sangat banyak. Dalam hukum ekonomi yang terus mengandalkan modal yang kecil dan juga ingin mendapatkan keuntungan yang sebesar-besarnya, tidak menutup kemungkinan pelaku usaha mendominasi pelaku usaha sehingga melakukan segala cara untuk mendapatkan keuntungan yang sangat besar. Padahal dalam hukum Islam telah dijelaskan bagaimana etika berbisnis secara syariah yang telah dicontohkan oleh Nabi Muhammad SAW. Penelitian ini bertujuan untuk menganalisis kesesuaian penerapan etika bisnis dalam transaksi jual beli online di Marketplace Lazada dengan etika bisnis syariah sesuai dengan aturan yang telah ditetapkan oleh Islam. Metode yang digunakan dalam penelitian ini adalah metode deskriptif untuk menggambarkan suatu objek atau subjek apa adanya untuk menyajikan realitas dan memiliki ciri-ciri objek yang diteliti secara tepat. Hasil penelitian menunjukkan bahwa etika bisnis Islam belum diterapkan dalam praktik jual beli di toko online dalam Marketplace Lazada serta penerapan praktik etika bisnis belum sesuai dengan dengan prinsip etika bisnis Islam.
PENERAPAN ISLAMIC MARKETING STRATEGY DAN ISLAMIC HUMAN RESOURCE MANAGEMENT DI UB. SURYA MADIUN
Authors: Fauziah Nur 
Published: November 2021

Surya Madiun is a company engaged in the retail sector, namely minimarkets that provide basic daily needs. At UB. Surya Madiun in implementing the company's activities uses a sharia-based marketing strategy system and Islamic Human Resource Management to improve the quality of the company. This research was conducted to find out how the implementation of Islamic Marketing Strategy and Islamic Human Resource Management in UB. Surya Madison. In this analysis, qualitative data analysis method is used, namely by interviewing parties from UB. Surya Madison. In field research procedures that produce descriptive data, in the form of written or oral data from the people or observed behavior. Therefore, in this study, every symptom related to Islamic Marketing Strategy and Islamic Human Resource Management in UB. Surya Madiun will be thoroughly researched and endeavored to give meaning to every phenomenon found.
Surya Madiun adalah sebuah perusahaan yang bergerak di bidang peretailan, yaitu minimarket yang menyediakan kebutuhan pokok sehari-hari. Di UB. Surya Madiun dalam pelaksanaan kegiatan perusahaan menggunakan sistem strategi pemasaran berbasis syariah serta Manajemen Sumber Daya Manusia yang Islami guna peningkatan kualitas perusahaan. Penelitian ini dilakukan guna mengetahui bagaimana penerapan Islamic Marketing Strategy dan Islamic Human Resource Management di UB. Surya Madiun. Dalam analisis ini menggunakan metode analisis data kualitatif, yaitu dengan cara mewawancarai pihak dari UB. Surya Madiun. Dalam prosedur penelitian lapangan yang menghasilkan data deskriptif, berupa data tertulis atau lisan dari orang-orang atau perilaku yang diamati. Oleh karena itu dalam penelitian ini dari setiap gejala yang terkait dengan Islamic Marketing Strategy dan Islamic Human Resource Management di UB. Surya Madiun akan diteliti secara menyeluruh serta diupayakan untuk memberikan makna dalam setiap fenomena yang ditemukan.