bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of tobacco control measures in the Gulf Cooperation Council countries, 2008–2020
Authors: Monshi Sarah S. , Ibrahim Jennifer 
Published: July 2021

AbstractBackgroundThe World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) was developed to assist nations in reducing the demand and supply of tobacco. As of 2020, 182 nations joined the FCTC, agreeing to implement the recommended tobacco control measures. The Gulf Cooperation Council (GCC) countries, including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE) ratified the WHO FCTC by August 2006. Given the unique political, cultural, and religious context – and known tobacco industry efforts to influence tobacco use- in these nations, a careful examination of the translation of FCTC measures into policy is needed. This study aimed to assess the implementation of FCTC tobacco control measures at the national level within the six GCC countries.MethodWe collected and coded the FCTC measures that were implemented in the GCC countries. We examined trends and variations of the implementation between 2008 and 2020.ResultsGCC countries implemented most FCTC measures targeting the demand for and supply of tobacco, with some variation among countries. Bahrain and Qatar were more comprehensively implementing FCTC measures while Kuwait and Oman implemented the least number of the FCTC measures. Implementing measures related to tobacco prices and eliminating the illicit tobacco trade has slowly progressed in GCC countries. All GCC countries entirely banned smoking in workplaces while three countries implemented a partial ban in restaurants. Only Oman has restrictions on tobacco ads shown in media. There is progress in implementing FCTC measures related to tobacco packaging, cessation, and sale to minors in most GCC countries.ConclusionsGiven the influence of the tobacco industry in the Gulf region, the findings suggest a need for ongoing surveillance to monitor the proliferation of tobacco control measures and evaluate their effectiveness. Efforts required to address tobacco use should correspond to the unique political and cultural background of the GCC countries.
Diagnosis and management of small bowel obstruction in virgin abdomen: a WSES position paper
Authors: Amara Yousef , Leppaniemi Ari , Catena Fausto , Ansaloni Luca , Sugrue Michael , Fraga Gustavo P. , Coccolini Federico , Biffl Walter L. , Peitzman Andrew B. , Kluger Yoram , Sartelli Massimo , Moore Ernest E. , Di Saverio Salomone , Darwish Esfo , Endo Chikako , van Goor Harry , ten Broek Richard P. 
Published: July 2021

AbstractBackgroundSmall bowel obstruction (SBO) is a common surgical emergency, causing high morbidity and healthcare costs. The majority of SBOs are caused by adhesions that result from previous surgeries. Bowel obstruction, however, also occurs in patients without previous operation or known pathology, a so called virgin abdomen. It is unknown if small bowel obstruction in the virgin abdomen (SBO-VA) can be managed according to the same principles as other cases of small bowel obstruction. The aim of this position paper is to evaluate the available evidence on etiology and management of small bowel obstruction in the virgin abdomen.MethodsThis is a narrative review with scoping aspects. Clinical topics covered in this review include epidemiology and etiology of SBO-VA, diagnosis and imaging, initial assessment, the role of surgical management in SBO-VA, and the role of non-operative management in SBO-VA.ResultsOur scoping search revealed seven original studies reporting original patient data related to SBO-VA. All the included studies are retrospective cohorts, with populations ranging between 44 and 103 patients with SBO-VA. Adhesions were found to be the cause of the obstruction in approximately half of the reported cases of SBO-VA. A relatively high number of cases of SBO-VA were managed surgically with studies reporting 39–83%. However, in cases where a trial of non-operative management was started, this was generally successful.ConclusionThe data available suggest that etiology and treatment results for patients with SBO-VA are largely comparable to the results in patients with SBO after previous abdominal surgery. We therefore propose that patients with a virgin abdomen could be treated according to existing guidelines for SBO and adhesive small bowel obstruction.
An updated national survey of triage and triage related work in Sweden: a cross-sectional descriptive and comparative study
Authors: Wireklint Sara C. , Elmqvist Carina , Göransson Katarina E. 
Published: July 2021

AbstractBackgroundTriage and triage related work has been performed in Swedish Emergency Departments (EDs) since the mid-1990s. According to two national surveys from 2005 to 2011, triage was carried out with different triage scales and without guidelines or formal education. Furthermore, a review from 2010 questioned the scientific evidence for both triage as a method as well as the Swedish five level triage scale Medical Emergency Triage and Treatment System (METTS); nevertheless, METTS was applied in 65% of the EDs in 2011. Subsequently, METTS was renamed to Rapid Emergency Triage and Treatment System (RETTS©). The hypothesis for this study is that the method of triage is still applied nationally and that the use of METTS/RETTS© has increased. Hence, the aim is to describe the occurrence and application of triage and triage related work at Swedish Emergency Departments, in comparison with previous national surveys.MethodsIn this cross-sectional study with a descriptive and comparative design, an electronic questionnaire was developed, based on questionnaire from previous studies. The survey was distributed to all hospital affiliated EDs from late March to the middle of July in 2019. The data was analysed with descriptive statistics, by IBM SPSS Statistics, version 26.ResultsOf the 51 (75%) EDs partaking in the study, all (100%) applied triage, and 92% used the Swedish triage scale RETTS©. Even so, there was low concordance in how RETTS© was applied regarding time frames i.e., how long a patient in respective triage level could wait for assessment by a physician. Additionally, the results show a major diversion in how the EDs performed education in triage.ConclusionThis study confirms that triage method is nationally implemented across Swedish EDs. RETTS© is the dominating triage scale but cannot be considered as one triage scale due to the variation with regard to time frames per triage level. Further, a diversion in introduction and education in the pivotal role of triage has been shown. This can be counteracted by national guidelines in what triage scale to use and how to perform triage education.
The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019
Authors: Huang Runzhi , Meng Tong , Zha Qiongfang , Cheng Kebin , Zhou Xin , Zheng Junhua , Zhang Dingyu , Liu Ruilin 
Published: July 2021

Abstract
Background
The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known.

Objective
The aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism.

Methods
The retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively.

Results
In total, 304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.020). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell–cell communication.

Conclusion
This study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell–cell communication of developing neutrophils and type II pneumocyte.
Adrenocortical adenoma with myelolipomatous metaplasia: a potential diagnostic pitfall: a case report and review of the literature
Authors: Anbardar Mohammad Hossein , Soleimani Neda , Nikeghbalian Saman , Mohebbi Maryam 
Published: July 2021

Abstract
Background
Adrenal incidentalomas are often found during investigation for another tumor or unrelated problems. Except for adrenal myelolipoma (second most common primary adrenal incidentaloma following adrenocortical adenomas), adrenal lipomatous tumors are uncommon generally and are often described as case reports in the literature. Since the amount of fat is variable, without the help of advanced imaging techniques, some adrenal lipomatous tumors may be misdiagnosed before pathologic examination. Herein, we report a case of adrenal adenoma with myelolipomatous metaplasia that was excised as a periceliac mass in the setting of recurrent pancreatic cyst.

Case report
A 45-year-old Iranian woman with hypertension and end-stage renal disease presented with recurrence of a pancreatic cyst (previous pathologic report was mucinous cyst adenoma). During exploratory laparotomy, the mentioned pancreatic cyst was tightly attached to the stomach and jejunum. There was also a periceliac round rubbery lesion (firstly diagnosed by endoscopic ultrasound) that was excised for ruling out malignancy. Histologic examination of the periceliac mass was found to be adrenocortical adenoma with foci of myelolipomatous metaplasia. The pancreatic cyst histology was just a pseudocyst.

Conclusion
Our case highlights the significance of complete evaluation of incidental findings before surgical intervention, even in the setting of another primary tumor. Myelolipoma and myelolipomatous change (metaplasia) are two different entities. Although very similar as to pathogenesis, there are still some differences.
Whole-body [18F]-FDG-PET/MRI for staging of pediatric non-Hodgkin lymphoma: first results from a single-center evaluation
Authors: Kurch L. , Kluge R. , Sabri O. , Fischer L. , Wendt S. , Graf Einsiedel H. , Starke S. , Kühl J.-S. , Christiansen H. , Hirsch F. W. , Sorge I. , Roth C. 
Published: July 2021

Abstract
Aim
In 2015, the revised International Pediatric Non-Hodgkin Lymphoma Staging System was published. It mentions [18F]-FDG-PET/MRI as the latest method to perform whole-body imaging. However, supporting data are pending. Our aim was to investigate the performance of whole-body [18F]-FDG-PET/MRI in pediatric non-Hodgkin lymphoma patients by using a limited number of MRI sequences.

Materials and methods
Ten pediatric patients with histologically proven non-Hodgkin lymphoma underwent whole-body [18F]-FDG-PET/MRI at staging. The retrospective analysis included three steps: First, [18F]-FDG-PET and MR scans were evaluated separately by a nuclear medicine physician and a pediatric radiologist. Nineteen nodal and two extranodal regions as well as six organs were checked for involvement. Second, discrepant findings were reviewed together in order to reach consensus. Third, [18F]-FDG-PET/MRI findings were correlated with the results of other clinical investigations.

Results
Of the 190 lymph node regions evaluated, four were rated controversial. Consensus was reached by considering metabolic, functional and morphologic information combined. Concordantly, [18F]-FDG-PET and MRI detected Waldeyer’s ring involvement in two patients whose Waldeyer’s ring was negative on clinical assessment. In four patients MRI showed pleural effusion. However, in only two of them an increased glucose metabolism as a reliable sign of pleural involvement was detectable. In six patients [18F]-FDG-PET and MRI detected skeletal lesions although bone marrow biopsy was positive in only one of them.

Conclusion
Despite the small number of cases evaluated, whole-body [18F]-FDG-PET turned out to be a valuable tool for staging of pediatric non-Hodgkin lymphoma.
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level
Authors: Ma Fen , Zhang Siwei , Song Lianhao , Wang Bozhi , Wei Lanlan , Zhang Fengmin 
Published: July 2021

Abstract
Background
Cellular communication is an essential feature of multicellular organisms. Binding of ligands to their homologous receptors, which activate specific cell signaling pathways, is a basic type of cellular communication and intimately linked to many degeneration processes leading to diseases.

Main body
This study reviewed the history of ligand-receptor and presents the databases which store ligand-receptor pairs. The recently applications and research tools of ligand-receptor interactions for cell communication at single cell level by using single cell RNA sequencing have been sorted out.

Conclusion
The summary of the advantages and disadvantages of analysis tools will greatly help researchers analyze cell communication at the single cell level. Learning cell communication based on ligand-receptor interactions by single cell RNA sequencing gives way to developing new target drugs and personalizing treatment.
Complex mathematical SIR model for spreading of COVID-19 virus with Mittag-Leffler kernel
Authors: Akyildiz F. Talay , Alshammari Fehaid Salem 
Published: July 2021

AbstractThis paper investigates a new model on coronavirus-19 disease (COVID-19), that is complex fractional SIR epidemic model with a nonstandard nonlinear incidence rate and a recovery, where derivative operator with Mittag-Leffler kernel in the Caputo sense (ABC). The model has two equilibrium points when the basic reproduction number $R_{0} > 1$

R
0

>
1
; a disease-free equilibrium $E_{0}$

E
0

and a disease endemic equilibrium $E_{1}$

E
1

. The disease-free equilibrium stage is locally and globally asymptotically stable when the basic reproduction number $R_{0} <1$

R
0

<
1
, we show that the endemic equilibrium state is locally asymptotically stable if $R_{0} > 1$

R
0

>
1
. We also prove the existence and uniqueness of the solution for the Atangana–Baleanu SIR model by using a fixed-point method. Since the Atangana–Baleanu fractional derivative gives better precise results to the derivative with exponential kernel because of having fractional order, hence, it is a generalized form of the derivative with exponential kernel. The numerical simulations are explored for various values of the fractional order. Finally, the effect of the ABC fractional-order derivative on suspected and infected individuals carefully is examined and compared with the real data.
Effects of COVID-19 prevention procedures on other common infections: a systematic review
Authors: Dadras Omid , Alinaghi Seyed Ahmad Seyed , Karimi Amirali , MohsseniPour Mehrzad , Barzegary Alireza , Vahedi Farzin , Pashaei Zahra , Mirzapour Pegah , Fakhfouri Amirata , Zargari Ghazal , Saeidi Solmaz , Mojdeganlou Hengameh , Badri Hajar , Qaderi Kowsar , Behnezhad Farzane , Mehraeen Esmaeil 
Published: July 2021

Abstract
Introduction
Since the outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) began, necessary measures to prevent virus transmission and reduce mortality have been implemented, including mandatory public use of masks, regular hand-sanitizing and hand-washing, social distancing, avoidance of crowds, remote work, and cancellation of public events. During and after the introduction of COVID-19 lockout, we performed a systematic review of available published literature to investigate the incidence of seasonal influenza and other respiratory viral infections.

Methods
PubMed, Embase, Web of Science, Scopus, Science Direct, Google Scholar, Research Gate, and the World Health Organization databases and websites were systematically searched for original studies concerning the impact of COVID-19 prevention means and measures on other common respiratory infectious diseases during the pandemic published by March 2021.

Results
The findings showed that the adherence to health protocols to prevent COVID-19 could help to reduce the incidence of other infectious diseases such as influenza, pneumonia, and Mycobacterium tuberculosis.

Conclusion
The implemented prevention measures and protocols might have reduced the incidence of influenza and some other common respiratory infections. However, controversies exist on this matter and future large population-based studies might provide further information to address these controversies.
Developing horizontal subsurface flow constructed wetland using pumice and Chrysopogon zizanioides for tannery wastewater treatment
Authors: Aregu Mekonnen Birhanie , Asfaw Seyoum Leta , Khan Mohammed Mazharuddin 
Published: July 2021

Abstract
Background
High-strength wastewater defined by elevated levels of hazardous pollutants measured in BOD, heavy metals, nutrients and other toxic substances. This kind of wastewater discharged to water body without treatment from different industrial sectors that adversely affects aquatic environment and downstream water consumers. The general objective of this study is to investigate efficient substrate with selected plant type for constructed wetland to remove hazardous pollutants from tannery wastewater. This study was conducted at Modjo town, Modjo tannery PLC. Plug flow experimental study design was carried out. The substrate (Pumice) was collected around the study area and chemical characteristics were determined. Chrysopogon zizanioides was planted and grown for 5 months before running tannery wastewater for the treatment. The composite wastewater was introduced to the constructed wetland from Modjo leather industry, Ethiopia. The physicochemical analysis of the sample wastewater was done before and after treatment at four different hydraulic retention time.

Results
Characterization of the untreated tannery wastewater revealed that the mean concentration of BOD5, COD, TSS, PO4-P, TP, NO3-N, TN and total chromium were 1641 ± 373.6, 6953.33 ± 339.4, 1868 ± 863.1, 88.06 ± 40.8, 144.53 ± 20.8, 116.66 ± 26.6, 650.33 ± 93.6 and 18.33 ± 6.7 mg/l respectively beyond the permissible limits. The maximum removal efficiency of the constructed wetland in pumice bed revealed that BOD5 at HRT 7and 9 days (96.42%, 96.30%), COD at HRT 5 and 7 days (96.76%, 96.91%), NO3-N at HRT 5 and 7 days (99.99%, 99.68%), TN (98.67%, 99.00%), PO4-P HRT 7and 9 days (96.97%,100%), TP at HRT 5 and 7 days (94.79%, 96.17%) and total Chromium at HRT 5 and 7 days (98.36%, 98.91%) respectively. Whereas, the removal efficiency of constructed wetland bed with gravel substrate used as a control subject with similar condition to pumice showed lower performance. The result between pumice and gravel bed was tested for their significance difference using two sample t-test statistics. Based on the test statistics, the pumice substrate perform better than the gravel significantly at 95% confidence interval, p-value = 0.01.

Conclusion
Pumice substrate and Chrysopogon zizanioides have a potential ability to remove hazardous pollutants from tannery wastewater in horizontal subsurface constructed wetlands.
‘A roller coaster of emotions’: a phenomenological study on medical students lived experiences of emotions in complex simulation
Authors: Behrens Claudia C. , Driessen Erik W. , Dolmans Diana H. , Gormley Gerard J. 
Published: July 2021

Abstract
Background
Simulation-based education can induce intense learner emotions. The interplay between emotions and learning is less well understood. Gaining greater insights into learner emotions has potential to guide how best we manage emotions and optimise learning. This study aimed to understand learners’ lived emotional experiences in complex simulation and the perceived impact on learning.

Methods
Eight final-year medical students participated in the study. Wearing video-glasses, participants took part in a ward-based simulation. Video-footage was used to elicitate exploratory interviews and analysed using Template Analysis reflexively.

Results
Analysis yielded four main themes: ‘nervous anticipation’: encapsulating the fear, anxiety and uncertainty experienced by learners prior to simulation; ‘shock and awe’: feelings of anxiousness and being overwhelmed at the start of a simulation; ‘in the moment: flowing or buffeting with the emotions’: experiencing fear of being judged as incompetent, but also experiencing positive emotions such as satisfaction; ‘safe-landing?’: whilst debriefing aimed to encourage more positive emotions, negative emotions about the simulation could persist even with debriefing.

Conclusions
Complex simulation can evoke intense emotions in students. If students experienced a positive progression, they reported positive emotions and felt competent which was perceived to have a positive impact on learning. If students experienced failure, they reported strong negative emotions which made them question about their future performance and was perceived as negative for learning. Bringing to the surface these complex emotional dynamics, could permit educators to be aware of and adapt the emotional climate within simulation in order to optimise learning.
Prevalence of diarrhea in end-stage renal disease patients initiating hemodialysis
Authors: Oba Miho , Minakuchi Hitoshi , Yoshida Tadashi 
Published: July 2021

Abstract
Background
Diarrhea is one of the symptoms occasionally seen in patients initiating hemodialysis. When they have diarrhea, they need several additional cares for defecation during the hemodialysis sessions and for infection control at dialysis facilities.

Methods
We retrospectively examined the prevalence and the characteristics of the patients with diarrhea initiating hemodialysis. Data were collected from medical records.

Results
Of 243 patients who initiated hemodialysis therapy, 46 patients (19%) had diarrhea. The age, gender, and etiology of end-stage renal disease did not differ between the patients with diarrhea and those without diarrhea. Body weight in the patients with diarrhea was lighter than those without diarrhea. The prevalence of concomitant diseases, such as cardiovascular diseases, malignancies, and diabetes, was not different between the groups, whereas the patients with diarrhea were complicated more frequently with infectious diseases. Antibiotics and steroids had been used more frequently in the patients with diarrhea (59% and 26%, respectively) than those without diarrhea (10% and 10%, respectively). Inflammatory markers, such as white blood cell numbers, C-reactive protein levels, and body temperature, were significantly higher in the patients with diarrhea. Serum levels of total protein, albumin, and creatinine were significantly lower in the patients with diarrhea, while urea nitrogen levels did not differ between the groups.

Conclusion
Results of the present study showed, for the first time, that 19% of the patients initiating hemodialysis had diarrhea and suggest that incident hemodialysis patients with infectious diseases and those under treatment with antibiotics and/or steroids are high-risk for diarrhea.