bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcium: A comprehensive review on quantification, interaction with milk proteins and implications for processing of dairy products
Authors: Barone Giovanni , Yazdi Saeed Rahimi , Lillevang Søren K. , Ahrné Lilia 
Published: October 2021

AbstractCalcium (Ca) is a key micronutrient of high relevance for human nutrition that also influences the texture and taste of dairy products and their processability. In bovine milk, Ca is presented in several speciation forms, such as complexed with other milk components or free as ionic calcium while being distributed between colloidal and serum phases of milk. Partitioning of Ca between these phases is highly dynamic and influenced by factors, such as temperature, ionic strength, pH, and milk composition. Processing steps used during the manufacture of dairy products, such as preconditioning, concentration, acidification, salting, cooling, and heating, all contribute to modify Ca speciation and partition, thereby influencing product functionality, product yield, and fouling of equipment. This review aims to provide a comprehensive understanding of the influence of Ca partition on dairy products properties to support the development of kinetics models to reduce product losses and develop added‐value products with improved functionality. To achieve this objective, approaches to separate milk phases, analytical approaches to determine Ca partition and speciation, the role of Ca on protein–protein interactions, and their influence on processing of dairy products are discussed.
The interactions between anthocyanin and whey protein: A review
Authors: Ren Shuai , Jiménez‐Flores Rafael , Giusti Maria Monica 
Published: October 2021

AbstractAnthocyanins (ACN) are natural pigments that produce bright red, blue, and purple colors in plants and can be used to color food products. However, ACN sensitivity to different factors limits their applications in the food industry. Whey protein (WP), a functional nutritional additive, has been shown to interact with ACN and improve the color, stability, antioxidant capacity, bioavailability, and other functional properties of the ACN‐WP complex. The WP's secondary structure is expected to unfold due to heat treatment, which may increase its binding affinity with ACN. Different ACN structures will also have different binding affinity with WP and their interaction mechanism may also be different. Circular dichroism (CD) spectroscopy and Fourier transform infrared (FTIR) spectroscopy show that the WP secondary structure changes after binding with ACN. Fluorescence spectroscopy shows that the WP maximum fluorescence emission wavelength shifts, and the fluorescence intensity decreases after interaction with ACN. Moreover, thermodynamic analysis suggests that the ACN‐WP binding forces are mainly hydrophobic interactions, although there is also evidence of electrostatic interactions and hydrogen bonding between ACN and WP. In this review, we summarize the information available on ACN‐WP interactions under different conditions and discuss the impact of different ACN chemical structures and of WP conformation changes on the affinity between ACN and WP. This summary helps improve our understanding of WP protection of ACN against color degradation, thus providing new tools to improve ACN color stability and expanding the applications of ACN and WP in the food and pharmacy industries.
Targeted paclitaxel‐octreotide conjugates inhibited the growth of paclitaxel‐resistant human non‐small cell lung cancer A549 cells in vitro
Authors: Liu Yanguo , Xia Handai , Wang Yawei , Han Wenfei , Qin Jing , Gao Wenjuan , Qu Xun , Wang Xiuwen 
Published: October 2021

AbstractThe application of chemotherapy in non‐small cell lung cancer (NSCLC) is limited by the toxicity to normal cells and the development of multi‐drug resistance. Targeted chemotherapy using cytotoxic analogs against specific receptors on cancer cells could be a less toxic and more efficacious approach. We identified that the expressions of somatostatin receptor (SSTR) 2 and 5 in tumor tissues from NSCLC patients were higher than those in the adjacent normal tissues by immunohistochemistry, and therefore, cytotoxic somatostatin analogues might be applied for SSTRs‐mediated targeted therapy against NSCLC. Two cytotoxic analogs, paclitaxel‐octreotide (PTX‐OCT) and 2paclitaxel‐octreotide (2PTX‐OCT), were synthesized by linking one or two molecules of paclitaxel to one molecule of somatostatin analog octreotide. PTX‐OCT and 2PTX‐OCT significantly inhibited the growth and induced apoptosis of SSTR2‐ and SSTR5‐positive A549 cells, compared with the control (p < 0.01), and had less inhibitory effect on SSTR2‐ and SSTR5‐negative H157 cells than paclitaxel (p < 0.01). Moreover, compared with paclitaxel, PTX‐OCT conjugates induced lower expression of MDR‐1 gene both in vitro and in vivo. Three A549 paclitaxel‐resistant cell lines were established through different approaches, and the paclitaxel‐resistant cell showed higher sensitivity to PTX‐OCT conjugates than to paclitaxel, which might be because of the differential MDR‐related gene expressions and cell‐cycle distribution in paclitaxel‐resistant A549 cells. Our results suggested that PTX‐OCT conjugates could be potentially used for SSTRs‐mediated targeted therapy for NSCLC, especially for those with paclitaxel resistance and induced less multidrug resistance.
Success rate of external cephalic version in relation to the woman’s body mass index and other factors—a population‐based cohort study
Authors: Svensson Emelie , Axelsson Daniel , Nelson Marie , Nevander Sofia , Blomberg Marie 
Published: October 2021

AbstractIntroductionThe aim of this study was to evaluate the impact of women’s body mass index (BMI) on the probability of a successful external cephalic version (ECV).Material and methodsA retrospective population‐based observational study including all women that underwent an ECV in the southeast region of Sweden from January 2014 to December 2019. Data were collected from electronic medical records, Obstetrix, Cerner. The women were divided into BMI categories according to the World Health Organization classification. Women with a BMI below 25 kg/m2 formed the reference group. Crude and adjusted odds ratios for unsuccessful ECV in each BMI group were calculated using binary logistic regression. Furthermore, the association between maternal characteristics and clinical and ultrasound variables at the time of the ECV and unsuccessful ECV was evaluated.ResultsA total of 2331 women were included. The overall success rate of ECV was 53.4%. Women with a BMI below 25 kg/m2 had a success rate of 51.3% whereas obese women had a success rate of 58.6%. The risk of an unsuccessful ECV among obese women (BMI ≥30 kg/m2) had an OR of 0.74 (95% CI 0.59–0.94) compared with women with a BMI below 25 kg/m2. After adjusting for suitable confounding factors, the association was no longer significant. Higher maternal age, multiparity, higher gestational age, posterior placenta position, polyhydramnios and higher estimated weight of the fetus at the ECV significantly decreased the risk of an unsuccessful ECV.ConclusionsMaternal obesity does not seem to negatively influence the success rate of ECV. This is a finding that may encourage both caregivers and obese pregnant women to consider an ECV and so avoid a planned cesarean section for breech presentation in this group.
Comparing risk of repeat surgery for stress urinary incontinence after mid‐urethral slings and polyacrylamide hydrogel
Authors: Svenningsen Rune , Oversand Sissel Hegdahl , Schiøtz Hjalmar August , Kulseng‐Hanssen Sigurd 
Published: October 2021

AbstractIntroductionOver the last two decades synthetic mid‐urethral slings (MUS) have become established as the main surgical method for correcting stress urinary incontinence (SUI). However, transurethral injections with polyacrylamide hydrogel are gaining popularity. We used surgical codes from a national registry to explore potential differences in risk of later surgery for SUI comparing retropubic slings, obturator slings, and polyacrylamide hydrogel injections.Material and methodsThis cohort study used surgical codes from The Norwegian Patient Registry. All women recorded as having had surgery for SUI coded as retropubic sling, obturator sling, or polyacrylamide hydrogel injection from 2008 until end‐of‐study censoring in 2017, were included. Main outcome was time to any recorded new SUI procedure later in the study period. Unadjusted comparison between groups was done using Kaplan–Meier. A Cox regression analysis was then performed to adjust for hospital unit size and patient age at surgery.ResultsThe unadjusted analyses showed significant differences between the chosen index method and the risk of later SUI surgery favoring retropubic slings (p < 0.01). The proportions of patients without any recorded new SUI procedure at 1 and 5 years were 99.3% and 97.7% for retropubic MUS, 98.7% and 96.1% for obturator MUS, and 82.7% and 72.4% for polyacrylamide hydrogel injections. The majority of women having a repeat procedure for SUI after a polyacrylamide hydrogel injection underwent repeat treatment within 1 year (63%). After adjusting for age at time of surgery and hospital size, obturator slings (hazard ratio 1.8, 95% CI 1.4–2.4) and polyacrylamide hydrogel (hazard ratio 23.1, 95% CI 17.6–30.3) remained associated with a higher risk of later incontinence surgery.ConclusionsBoth retropubic and obturator slings have low long‐term risks of repeat incontinence surgery compared with polyacrylamide hydrogel injections. Retropubic slings were found to have superior longevity of the surgical result.
Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts
Authors: van Suylen Vincent , Vandendriessche Katrien , Neyrinck Arne , Nijhuis Foppe , van der Plaats Arjan , Verbeken Erik K. , Vermeersch Pieter , Meyns Bart , Mariani Massimo A. , Rega Filip , Erasmus Michiel E. 
Published: October 2021

AbstractBackgroundThere is a continued interest in ex situ heart perfusion as an alternative strategy for donor heart preservation. We hypothesize that oxygenated machine perfusion of donor hearts at a temperature that avoids both normothermia and deep hypothermia offers adequate and safe preservation.MethodsCardioplegia‐arrested porcine donor hearts were randomly assigned to six hours of preservation using cold storage (CS, n = 5) or machine perfusion using an oxygenated acellular perfusate at 21°C (MP, n = 5). Subsequently, all grafts were evaluated using the Langendorff method for 120 min. Metabolic parameters and histology were analyzed. Systolic function was assessed by contractility and elastance. Diastolic function was assessed by lusitropy and stiffness.ResultsFor both groups, in vivo baseline and post‐Langendorff biopsies were comparable, as were lactate difference and myocardial oxygen consumption. Injury markers gradually increased and were comparable. Significant weight gain was seen in MP (p = 0.008). Diastolic function was not impaired in MP, and lusitropy was superior from 30 min up to 90 min of reperfusion. Contractility was superior in MP during the first hour of evaluation.ConclusionWe conclude that the initial functional outcome of MP‐preserved hearts was transiently superior compared to CS, with no histological injury post‐Langendorff. Our machine perfusion strategy could offer feasible and safe storage of hearts prior to transplantation. Future studies are warranted for further optimization.
A systematic review of near work and myopia: measurement, relationships, mechanisms and clinical corollaries
Authors: Gajjar Shail , Ostrin Lisa A. 
Published: October 2021

ABSTRACTAfter decades of investigation, the role of near work in myopia remains unresolved, with some studies reporting no relationship and others finding the opposite. This systematic review is intended to summarize classic and recent literature investigating near work and the onset and progression of myopia, potential mechanisms and pertinent clinical recommendations. The impact of electronic device use is considered. PubMed and Medline were used to find peer‐reviewed cross‐sectional and longitudinal studies related to near work and myopia from 1980 to July 2020 using the PRISMA checklist. Studies were chosen using the Joanna Briggs Institute checklist, with a focus on studies with a sample size greater than 50. Studies were independently evaluated; conclusions were drawn per these evaluations. Numerous cross‐sectional studies found increased odds ratio of myopia with increased near work. While early longitudinal studies failed to find this relationship, more recent longitudinal studies have found a relationship between myopia and near work. Rather than daily duration of near work, interest has increased regarding absolute working distance and duration of continuous near viewing. Several reports have found that shorter working distances (<30 cm) and continuous near‐work activity (>30 min) are risk factors for myopia onset and progression. Novel objective continuously measuring rangefinding devices have been developed to better address these questions. The literature is conflicting, likely due to the subjective and variable nature in which near work has been quantified and a paucity of longitudinal studies. We conclude that more precise objective measures of near viewing behaviour are necessary to make definitive conclusions regarding the relationship between myopia and near work. Focus should shift to utilizing objective and continuously measuring instruments to quantify near‐work behaviours in children, followed longitudinally, to understand the complex factors related to near work. A better understanding of the roles of absolute working distance, temporal properties, viewing breaks and electronic device use on myopia development and progression will aid in the development of evidence‐based clinical recommendations for behavioural modifications to prevent and slow myopia.
Impact of timing of PERT on gastrointestinal symptoms in Danish children and adolescents with CF
Authors: Raun Anne Mette Terp , Brekke Ghita , Mølgaard Christian , Jaudszus Anke , Mainz Jochen G. , Pressler Tacjana , Skov Marianne 
Published: October 2021

AbstractAimGastrointestinal (GI) symptoms are often reported by CF patients. Despite a proven relation to exocrine pancreatic insufficiency (PI), it remains unclear whether GI symptoms are related to the timing of pancreatic enzyme replacement therapy (PERT). Whereas most international recommendations suggest administration of PERT at the beginning of meals, it has not been studied whether such a proceeding is associated with lower burden of symptoms. Methods: Thirty CF patients aged 0–17 years of age with PI were randomised to four weeks of PERT prior to meals followed by four weeks of PERT after meals or vice versa. Using the CF‐specific validated CFAbd‐Score, abdominal pain, dysfunctional bowel habits and Quality of Life (QoL) related to GI symptoms were assessed in relation to the timing of PERT. Data were analysed using a linear mixed model. Results: There was no significant difference regarding abdominal pain, bowel habits or QoL related to GI symptoms when timing of PERT was changed from prior to after meals. Conclusion: No significant difference was found when administration mode of PERT changed from prior to after meals or vice versa. However, after an individual assessment, some patients may profit from changing administration mode of PERT from prior to after meals.
Provenances and production techniques of the so‐called ‘Port Saint Symeon ware’ (13th–early 14th centuries ce) from Kinet Höyük (Cilicia, Turkey): Witnessing interactions in the medieval north‐eastern Mediterranean
Authors: Burlot Jacques , Waksman Sylvie Yona 
Published: October 2021

AbstractOne of the most widely distributed ceramics in the North‐eastern Mediterranean during the 13th century ce was the ceramic commonly called ‘Port Saint Symeon ware’, whose iconography reflects multicultural influences and traditions. Samples coming mainly from the archaeological site of Kinet Höyük (Cilicia, Turkey), as well as from several sites in the Mediterranean, enabled us to define the output of two production centres of Port Saint Symeon ware based on archaeological data and wavelength‐dispersive X‐ray fluorescence spectrometry (WD‐XRF) analyses of the ceramic bodies. The materials and recipes used for their decoration—glazes, slips and colorants—were investigated by scanning electron microscopy with energy‐dispersive spectroscopy (SEM‐EDS). The results show that the two production centres had very different scales of diffusion, but shared similar decoration techniques that might be considered as standardized. They consisted of the application of a transparent high‐Pb glaze on a ‘hybrid’ vitrified clayey slip, rich in angular siliceous inclusions, whose features suggest technical influences of the Islamic tradition. The potters of the Port Saint Symeon ware seem to have selected inclusions and K‐rich clays in order to obtain off‐white slips which are visually and technically close to synthetic ones.
Genetic polymorphism of bovine beta‐casein gene in Japanese dairy farm herds
Authors: Yamada Asaha , Sugimura Miyu , Kuramoto Takashi 
Published: October 2021

AbstractThe aim of this study was to investigate beta‐casein polymorphism among 320 Japanese cows sampled from eight dairy farms. We used a newly‐developed genotyping method that involved collecting DNA from hairs and a Cycleave polymerase chain reaction (PCR) assay to detect the A1, A2, and B variants. Results revealed the presence of five genotypes (A1A1, A2A2, A1A2, A1B, and A2B). We found that the most common genotype was A2A2 (0.42), followed by A1A2 (0.39) and A1A1 (0.11). The A1B and A2B genotypes were less frequent (<0.05). The frequencies of alleles A1, A2, and B were calculated to be 0.32, 0.64, and 0.04, respectively. Our study is the first to show the current status of beta‐casein polymorphisms in Japanese dairy farms. Given the adverse effects of A1 beta‐casein on human health, attempts have been made to develop herds consisting solely of A2A2 cows. Our study provides a reference for improving cow populations in Japanese dairy farms. The Cycleave PCR‐based assay we developed here can be used for rapid and reliable genotyping of bovine beta‐casein.
Switching between reference adalimumab and biosimilars in chronic immune‐mediated inflammatory diseases: A systematic literature review
Authors: García‐Beloso Nerea , Altabás‐González Irene , Samartín‐Ucha Marisol , Gayoso‐Rey Mónica , De Castro‐Parga María Luísa , Salgado‐Barreira Ángel , Cibeira‐Badia Amelia , Piñeiro‐Corrales María Guadalupe , González‐Vilas Daniel , Pego‐Reigosa Jose María , Martínez‐López de Castro Noemí 
Published: October 2021

AimsAdalimumab is a biological therapy used to treat different chronic inflammatory diseases. At present, there is an increasing number of adalimumab biosimilars. To assume the acceptability of interchangeability between reference adalimumab and biosimilars, there should be evidence about efficacy and safety of this switching. Regulation of this practice falls under the authority of individual European Union Member States. The aim of this study is tosystematically review the evidence on the efficacy, safety and immunogenicity of switching between reference adalimumab and biosimilars in different chronic immune‐mediated inflammatory diseases.MethodsStudies presenting data about switching between reference adalimumab and biosimilars were identified by sensitive search strategies in Medline and EMBASE from 1 January 2004 to 30 June 2021.ResultsA total of 471 references were obtained and 21 finally included in the analysis (total number of patients switching: 2802). Eight different adalimumab biosimilars were tested after receiving reference adalimumab. Eight articles included rheumatoid arthritis (RA), one miscellaneous rheumatic disease, six psoriasis (PSO) and six inflammatory bowel disease (IBD) patients. Overall, the efficacy results in the switching groups were comparable to those obtained in the arms of continuous biosimilar and continuous reference adalimumab. There were no significant differences in treatment emergent adverse events, anti‐drug or neutralising antibodies among the three groups.ConclusionsSwitching between reference adalimumab and biosimilars has no impact on efficacy, safety and immunogenicity in patients with RA, PSO and IBD. This finding was consistent for the different adalimumab biosimilars analysed. These conclusions could probably be extended to other rheumatic diseases such as psoriatic arthritis and ankylosing spondylitis.
Association of proton‐pump inhibitor use with adverse health outcomes: A systematic umbrella review of meta‐analyses of cohort studies and randomised controlled trials
Authors: Veettil Sajesh K. , Sadoyu Saranrat , Bald Elizabeth M , Chandran Viji P. , Khuu Scott Anh Tuan , Pitak Panitan , Lee Yeong Yeh , Nair Athira Balakrishnan , Antony Paul T. , Ford Alexander C. , Chaiyakunapruk Nathorn 
Published: October 2021

AimsThe aim was to perform an umbrella review to summarise the existing evidence on proton‐pump inhibitor (PPI) use and adverse outcomes and to grade the certainty of evidence.MethodsElectronic databases were searched up to July 2021 for meta‐analyses of cohort studies and/or randomised controlled trials (RCTs). Summary effect sizes from a random‐effects model, between‐study heterogeneity, 95% prediction interval, small‐study effect, excess significance and credibility ceilings were devised to classify the credibility of evidence from meta‐analyses of cohort studies, whereas the GRADE approach was used for meta‐analyses of RCTs.ResultsIn meta‐analyses of cohort studies, 52 of the 91 examined associations were statistically significant (P ≤ .05). Convincing evidence emerged from main analysis for the association between PPI use and risk of all‐site fracture and chronic kidney disease in the elderly population. However, none of these associations remained supported by convincing evidence after sensitivity analyses. The use of PPI is also associated with an increased risk of mortality due to COVID‐19 infection and other related adverse outcomes, but the quality of evidence was weak. In meta‐analyses of RCTs, 38 of the 63 examined associations were statistically significant. However, no associations were supported by high or moderate‐quality evidence.ConclusionThis study's findings imply that most putative adverse outcomes associated with PPI use may not be supported by high‐quality evidence and are likely to have been affected by underlying confounding factors. Future research is needed to confirm the causal association between PPI use and risk of fracture and chronic kidney disease.