bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent Validity Between Two Sound Sequencing Tasks Used to Identify Childhood Apraxia of Speech in School-Age Children
Authors: Preston Jonathan L. , Benway Nina R. , Leece Megan C. , Caballero Nicole F. 
Published: March 2021

Purpose
To assess the concurrent validity of two tasks used to inform diagnosis of childhood apraxia of speech (CAS), this study evaluated the agreement between the Syllable Repetition Task (SRT) and the Maximum Repetition Rate of Trisyllables (MRR-Tri).

Method
A retrospective analysis was conducted with 80 children 7–16 years of age who were referred for treatment studies. All children had a speech sound disorder, and all completed both the SRT and the MRR-Tri. On each task, children were classified as meeting or not meeting the tool's threshold for CAS based on the sound sequencing errors demonstrated.

Results

The two tasks were in agreement for 47 participants (59% of the sample); both tasks classified 13 children as meeting the threshold for CAS and 34 children as not meeting the threshold for CAS. However, the two tasks disagreed on CAS classification for 33 children (41% of the sample). Overall, the MRR-Tri identified more children as having sound sequencing errors indicative of CAS (
n
= 39) than did the SRT (
n
= 20).

Conclusions
These two tasks of sound sequencing differ in the children they identify with CAS, possibly due to aspects of the underlying task requirements (e.g., time pressure). The SRT and the MRR-Tri should not be used in isolation to identify CAS but may be useful as part of a balanced CAS assessment battery that includes additional tasks that inform the nature of the impairment and that aid treatment planning.

Supplemental Material

https://doi.org/10.23641/asha.14110280
SVM‐based online learning for interference‐aware multi‐cell mmWave vehicular communications
Authors: Li Dapeng , Zhu Jiangpei , Zhao Haitao , Wang Xiaoming , Jiang Rui 
Published: March 2021

AbstractThis paper proposes a data‐driven method of mmWave beam selection in multi‐cell systems to achieve a near‐optimal fast beam allocation with low complexity. In particular, an online learning algorithm based on support vector machine (SVM) equipped with the radial basis function kernel, namely SVM‐based online beam selection (SBOS) algorithm is proposed. The proposed algorithm starts with an adaptive beam selection process for certain traffic pattern that uses an SVM learning model to adaptively refine the beam selection strategy. Specifically, SVM‐based model labels the feedback (the average information rate) from the cellular system, then learns from samples, and makes the scheme space smaller by maximising samples' minimum distances to all labelled samples in the sample space constrained by newly learned boundaries. Then, according to the aggregated data about the traffic patterns and the performance of corresponding beam selection strategy, SBOS algorithm exploits beam selection schemes recorded in the database or explores new schemes for unknown situations, respectively, and how to tune the hyperparameters for the SBOS algorithm is discussed. Furthermore, the extensive simulation results show that the proposed algorithm achieves a better performance versus upper confidence bound and Random methods.
Non‐fragile H∞ control for LPV‐based CACC systems subject to denial‐of‐service attacks
Authors: Huang Cong , Karimi Hamid Reza 
Published: March 2021

AbstractThis paper is concerned with a non‐fragile state feedback control issue for linear parameter‐varying collaborative adaptive cruise control systems subject to denial‐of‐service attacks. The dynamics of the collaborative adaptive cruise control system is described by a linear model where the deviation of the position and the velocity are selected as the state variables. The attack model is utilized, thereby better reflecting the randomly occurring phenomenon of the denial‐of‐service attacks based on a sequence of binary random variables. The main objective of this note is to develop a non‐fragile state feedback control scheme such that, for denial‐of‐service attacks and possible parameter variations in controller gains, the exponential mean‐square stability and the predefined performance index for the system states are guaranteed simultaneously. By using the matrix analysis techniques and Lyapunov stability theory, sufficient conditions for the desired controller are established and solved based on the solutions to the linear matrix inequality conditions. Finally, a three‐car model is provided to check the feasibility of the designed control scheme.
CSIS: Compressed sensing‐based enhanced‐embedding capacity image steganography scheme
Authors: Agrawal Rohit , Ahuja Kapil 
Published: March 2021

AbstractImage steganography plays a vital role in securing secret data by embedding it in the cover images. Usually, these images are communicated in a compressed format. Existing techniques achieve this but have low embedding capacity. Hence, the goal here is to enhance the embedding capacity while preserving the visual quality of the stego‐image. It is also intended to ensure that the scheme is resistant to steganalysis attacks. This paper proposes a compressed sensing image steganography (CSIS) scheme to achieve these goals. In CSIS, the cover image is sparsified block‐wise, linear measurements are obtained, and then permissible measurements are selected. Next, the secret data is encrypted, and 2 bits of this encrypted data are embedded into each permissible measurement. For the reconstruction of the stego‐image, ADMM and LASSO are used for the resultant optimization problem. Experiments are performed on several standard greyscale images and a colour image. Higher embedding capacity, 1.53 times more compared to the most recent scheme, is achieved. An average of 37.92 dB PSNR value, and average values close to 1 for both the mean SSIM index and the NCC coefficients are obtained, which is considered good. These metrics show that CSIS substantially outperforms existing similar steganography schemes.
Investigation of novel thermoelectric sensor array configurations operating under non‐uniform temperature distribution conditions for the measurement of maximum output power in an energy harvesting system
Authors: Thankakan Rakesh , Samuel Nadar Edward Rajan 
Published: March 2021

AbstractThis research work proposes a configuration study of thermoelectric module (TEM) sensor array operating under uniform and non‐uniform temperature distribution (NUTD) conditions. The four different (10 × 10) TEM array configurations, which are electrically connected in series‐parallel (SP), all‐tied (AT), bridge‐joint (BJ), and bee‐hive (BH), are considered to evaluate its performance under six cases of NUTD conditions. The electrical characteristics of the various sensor array configurations has been analysed and tested under both temperature distribution conditions using MATLAB‐Simulink. A comparison of results of the various configurations is carried out in terms of maximum output power, voltage and current corresponding to maximum power, utilization factor, losses, relative error, standard deviation, and root mean square error. The maximum output power obtained from various cases of NUTD conditions confirm that the performance of bridge‐joint configuration is best than all other configurations in the field of thermoelectric energy harvesting systems.
Psychosomatische Rehabilitation bei Patientinnen und Patienten mit Rentenüberlegungen: Reha-Erfolg und therapeutische Beziehung
Authors: Henn Jessica , Kessemeier Franziska , Kobelt-Pönicke Axel , Bassler Markus , Schmidt Jürgen , Nübling Rüdiger 
Published: March 2021

Zusammenfassung
Ziel der Studie Rehabilitand(inn)en mit latentem oder manifestem Rentenwunsch gelten als Problemgruppe für eine erfolgreiche Reha-Teilnahme und anschließende berufliche Wiedereingliederung. Diese Patient(innen)gruppe zu erreichen, ist zum einen gesetzlicher Auftrag und zum anderen aus gesundheitlicher und wirtschaftlicher Perspektive von Bedeutung. Die vorliegende Arbeit untersucht Patient(inn)en, die zu Beginn ihrer Reha-Maßnahme überlegen, einen Antrag auf Erwerbsminderungsrente zu stellen. Fragestellungen sind, ob sich diese Personen hinsichtlich soziodemografischer Variablen und des Reha-Erfolgs von solchen ohne Rentenüberlegung unterscheiden und welche Patient(inn)en trotz Rentenüberlegung von ihrer Rehabilitation profitieren. Besonders berücksichtigt wird dabei die therapeutische Beziehung.
Methodik Die Daten entstammen der Routinedokumentation zweier Rehabilitationskliniken, die zwischen Oktober 2012 und Februar 2017 in stationärer psychosomatischer Rehabilitationsbehandlung erhoben wurden (N=8503).
Ergebnisse Rehabilitand(inn)en mit Rentenüberlegung waren etwas älter, häufiger arbeitsunfähig und bezogen häufiger Arbeitslosengeld. Bei beiden Gruppen zeigte sich bei Entlassung eine signifikante Reduktion der selbstberichteten Symptome. Innerhalb der Gruppe mit Rentenüberlegung berichteten Personen, die eine Symptombesserung angaben, von einer positiveren Beziehungszufriedenheit.
Diskussion/Schlussfolgerung Soziodemografische Ausgangsbedingungen und eine ausgeprägte Symptomatik von Patient(inn)en mit Rentengedanken sind Voraussetzungen, die eine psychosomatische Rehabilitation erschweren können. Dennoch berichten viele von einer Besserung der psychosomatischen Symptomatik und einer positiven therapeutischen Beziehung.
Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway
Authors: Wang Dingkun , Ren Yanlin , Sun Wei , Gong Jing , Zou Xin , Dong Hui , Xu Lijun , Wang Kaifu , Lu Fuer 
Published: March 2021

AbstractBerberine is an isoquinoline derivative alkaloid extracted from Chinese herbs. Recent studies have demonstrated the therapeutic effect of berberine on glucose metabolic disorders. However, its specific mechanism is still unclear. Our study aimed to research the glucose-lowering effect of berberine in diabetic rats and to reveal the possible role of the cholinergic anti-inflammatory pathway. Diabetic rats induced by administration of a high-calorie diet and streptozocin tail vein injection were assessed by the oral glucose tolerance test. Then, the diabetic rats were divided into two groups, those with or without the alpha7 nicotinic acetylcholine receptor gene downregulated, respectively, followed by treatment including berberine for 6 weeks. Results of this study show that the administration of berberine downregulated levels of fasting blood glucose and fasting insulin, and ameliorated insulin resistance in diabetic rats. Treatment with berberine inhibited acetylcholinesterase activity, and upregulated acetylcholine levels in the serum and alpha7 nicotinic acetylcholine receptor gene expression in the liver tissue. Meanwhile, berberine reversed elevated expression of cytokines interleukin-1β and TNF-α in the serum and downregulated nuclear factor κB expression. However, berberine administration showed no glucose-lowering or anti-inflammatory effect in diabetic rats in which alpha7 nicotinic acetylcholine receptor gene expression was downregulated, and acetylcholinesterase activity was also significantly inhibited. In conclusion, berberine may ameliorate glucose metabolism by activating the alpha7 nicotinic acetylcholine receptor-mediated cholinergic anti-inflammatory pathway.
Utilization and reproducibility of World Endoscopy Organization post-colonoscopy colorectal cancer algorithms: retrospective analysis
Authors: Beaton David , Beintaris Iosif , Rutter Matthew D. 
Published: March 2021

AbstractBackground Colorectal cancer (CRC) diagnosed following a cancer-negative colonoscopy is termed post-colonoscopy CRC (PCCRC). In addition to calculating PCCRC rates, the World Endoscopy Organization (WEO) recommends review of individual PCCRC cases, including categorization into interval/non-interval PCCRCs, and root cause analysis to determine the most plausible explanation. We aimed to test the usability, reproducibility, and outcomes of the WEO algorithms.Methods All CRC cases diagnosed from January 2015 to December 2016 in a single organization were cross referenced with local endoscopy and pathology databases to identify cases of PCCRC. We assessed: 1) WEO most plausible explanation for PCCRC; and 2) WEO PCCRC interval/non-interval subtype categorization. Interobserver agreement was measured using Cohen’s kappa (κ). Cases with interobserver variation underwent panel discussion to reach consensus.Results Among 527 patients with CRC, 48 PCCRCs were identified. A consistent most plausible explanation was found in 97 % of cases, showing almost perfect agreement (κ = 0.94). Most PCCRCs (66 %) were attributed to “possible missed lesion, prior examination adequate.” Interval/non-interval categorization was consistent in 77 %, showing substantial agreement (κ = 0.67). Following panel discussion, consensus was reached in all cases. Overall, 15 % were categorized as interval and 85 % as non-interval PCCRCs (12 % type A, 31 % type B, and 42 % type C).Conclusions Review of PCCRC cases using WEO recommendations was performed accurately at a local level using readily available clinical information. The high number of non-interval type B PCCRCs suggests a significant proportion of PCCRCs could be avoided by better adherence to recommended surveillance intervals.
Giant electrostrictive coefficient in rapidly cooled nanodisordered KTa1−xNbxO3 lead-free single crystals
Authors: Shang Annan , Chen Chang-Jiang , Liu Ruijia , Lee Yun Goo , Chao Ju-Hung , Yin Shizhuo 
Published: March 2021

The temperature dependent electrostrictive effect, with respect to increasing the cooling rate to a cooling temperature, was quantitatively investigated in potassium tantalate niobate (KTN) lead-free single crystals above and near Curie temperature (TC). High work-function Pt electrodes are used to minimize the effect of charge injection, and the electric field induced displacement was measured with Michelson interferometry. It was found that a giant electrostrictive coefficient of 696 × 10−16 m2/V2 could be obtained at a high cooling rate of 0.75 °C/s to a temperature of TC + 4.5 °C due to the evolution of polar nano-regions, which is one order of magnitude larger than the previously reported value in KTN crystals. This strengthens the realization of replacing toxic lead-based electrostrictive materials with environmentally friendly KTN materials in real world applications.
Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer
Authors: Park Jeongwoo , Park Byullee , Kim Tae Yeong , Jung Sungjin , Choi Woo June , Ahn Joongho , Yoon Dong Hee , Kim Jeongho , Jeon Seungwan , Lee Donghyun , Yong Uijung , Jang Jinah , Kim Won Jong , Kim Hong Kyun , Jeong Unyong , Kim Hyung Ham , Kim Chulhong 
Published: March 2021

Significance
Multimodal imaging based on optics and ultrasound can provide guide images and complementary structural and functional information, thus improving the accuracy of medical diagnosis and treatment monitoring. However, because conventional ultrasound transducers are opaque, in multimodal imaging with optics, the optical devices must be placed off-axis from the ultrasound transducer. This off-axis arrangement is prone to misalignment, adds complexity and bulk to the system, and can result in a low signal-to-noise-ratio. Here, we present a transparent ultrasound transducer at the heart of a quadruple fusion imaging system that seamlessly integrates ultrasound imaging, photoacoustic imaging, optical coherence tomography, and fluorescence imaging, and we demonstrate the system’s use in imaging responses to both ophthalmologic injuries and oncologic diseases.
JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging
Authors: Müller Katrin , Honcharova-Biletska Hanna , Koppe Christiane , Egger Michèle , Chan Lap Kwan , Schneider Anne T. , Küsgens Lena , Böhm Friederike , Boege Yannick , Healy Marc E. , Schmitt Johannes , Comtesse Sarah , Castoldi Mirco , Preisinger Christian , Szydlowska Marta , Focaccia Enrico , Gaisa Nadine T. , Loosen Sven H. , Jörs Simone , Tacke Frank , Roderburg Christoph , Keitel Verena , Bode Johannes G. , Boor Peter , Davis Roger J. , Longerich Thomas , Geisler Fabian , Heikenwalder Mathias , Weber Achim , Vucur Mihael , Luedde Tom 
Published: March 2021

Significance
JNK signaling has been studied intensively in models of liver physiology and disease, but previous studies had focused on young mice. However, it had not been recognized that JNK plays a fundamental role in maintaining liver homeostasis and preventing the formation of biliary cysts in aging mice. These observations call for caution in all long-term pharmacological inhibition strategies targeting the JNK pathway. Finally, our results provide evidence of a molecular link between JNK and the cell-death mediator RIPK1. The specific overexpression of RIPK1 in cysts of a subset of patients with polycystic liver disease suggests that RIPK1 might be mechanistically involved in the pathogenesis of human biliary cysts.
Screening for gene expression fluctuations reveals latency-promoting agents of HIV
Authors: Lu Yiyang , Bohn-Wippert Kathrin , Pazerunas Patrick J. , Moy Jennifer M. , Singh Harpal , Dar Roy D. 
Published: March 2021

Significance
Strategies to stabilize and suppress the latent cell reservoir of HIV have been proposed and need to be carefully examined. We demonstrate the use of time-lapse fluorescence microscopy to quantify HIV gene-expression dynamics and detect several latency-promoting agents (LPAs) that would be overlooked when screening for mean gene expression alone. These LPAs are structurally and functionally related to inhibitors of the thioredoxin/thioredoxin reductase redox pathway, which has been suggested as a promising HIV target. Some LPAs are Food and Drug Administration–approved and commercially available and can expand the currently limited LPA repertoire. This study provides a foundation to research suppression mechanisms of HIV gene expression, alternative latency-promoting therapies, and ultimately remove the need for antiretroviral therapy in patients.
Long-read assembly of a Great Dane genome highlights the contribution of GC-rich sequence and mobile elements to canine genomes
Authors: Halo Julia V. , Pendleton Amanda L. , Shen Feichen , Doucet Aurélien J. , Derrien Thomas , Hitte Christophe , Kirby Laura E. , Myers Bridget , Sliwerska Elzbieta , Emery Sarah , Moran John V. , Boyko Adam R. , Kidd Jeffrey M. 
Published: March 2021

Significance
Advancements in long-read DNA sequencing technologies provide more comprehensive views of genomes. We used long-read sequences to assemble a Great Dane dog genome that provides several improvements over the existing reference derived from a Boxer. Assembly comparisons revealed that gaps in the Boxer assembly often occur at the beginning of protein-coding genes and have a high-GC content, which likely reflects limitations of previous technologies in resolving GC-rich sequences. Dimorphic LINE-1 and SINEC retrotransposons represent the predominant differences between the Great Dane and Boxer assemblies. Proof-of-principle experiments demonstrated that expression of a canine LINE-1 could promote the retrotransposition of itself and a SINEC_Cf consensus sequence in cultured human cells. Thus, ongoing retrotransposon activity is a major contributor to canine genetic diversity.
A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming
Authors: Padmanarayana Murugesh , Liu Haowen , Michelassi Francesco , Li Lei , Betensky Daniel , Dominguez Matthew J. , Sutton R. Bryan , Hu Zhitao , Dittman Jeremy S. 
Published: March 2021

Significance
Rapid communication between neurons relies on the precise coordination of several presynaptic active-zone proteins. Munc13/UNC-13 is the centerpiece of this deeply conserved process, and several domains of this large cytoplasmic protein serve specific roles such as coordinating SNARE protein assembly, integrating calcium and lipid signals, and bringing synaptic vesicles close to the plasma membrane, although a mechanistic understanding of these critical steps is lacking. Here, we describe for the first time a novel C2 domain (HC2M) at the C terminus of UNC-13 that helps to bind synaptic vesicles to the plasma membrane in preparation for fusion. We demonstrate the impact of HC2M loss on nervous system function and characterize its structural, biochemical, and evolutionarily conserved features.
A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
Authors: Li Lulu , Zhang Hehong , Chen Changhai , Huang Haijian , Tan Xiaoxiang , Wei Zhongyan , Li Junmin , Yan Fei , Zhang Chuanxi , Chen Jianping , Sun Zongtao 
Published: March 2021

Significance
To accomplish the infection cycle, plant viruses usually employ various pathogenic factors to inhibit host antiviral defense. Revealing pathogenic mechanisms conserved among different viruses is essential for developing broad-spectrum disease control. Here, we show that a class of independently evolved transcriptional repressors is widely present in different plant viruses. Despite the diverse sequences and different evolutionary origins, these transcriptional repressors all modulate JA signaling by inhibiting the transcriptional activation of OsMYC transcription factors, disassociating the OsMED25-OsMYC complex, and cooperating with OsJAZ to improve their transcriptional repression activity. This facilitates viral infection and enhances vector feeding. Our findings reveal key functions of the transcriptional repressors in plant viruses and shed light on the general mechanism of viral pathogenicity and vector transmission.
Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors
Authors: Helfinger Valeska , Freiherr von Gall Florian , Henke Nina , Kunze Michael M. , Schmid Tobias , Rezende Flavia , Heidler Juliana , Wittig Ilka , Radeke Heinfried H. , Marschall Viola , Anderson Karen , Shah Ajay M. , Fulda Simone , Brüne Bernhard , Brandes Ralf P. , Schröder Katrin 
Published: March 2021

SignificanceThe stereotype of ROS produced by NADPH oxidases as cause of malignant diseases persists in a generalized manner. In fact, high levels of ROS formation could be harmful in the context of a disease process. This study demonstrates that loss of the NADPH oxidase Nox4, as a constitutive source of ROS, promotes cancerogen-induced formation of solid tumors. Accordingly, a certain tonic, constitutive low level of Nox4-derived hydrogen peroxide appears to reduce the risk of cancerogen-induced tumor formation.
Improved photosynthetic capacity and photosystem I oxidation via heterologous metabolism engineering in cyanobacteria
Authors: Santos-Merino María , Torrado Alejandro , Davis Geoffry A. , Röttig Annika , Bibby Thomas S. , Kramer David M. , Ducat Daniel C. 
Published: March 2021

Significance
Cyanobacteria have been increasingly explored as a biotechnological platform, although their economic feasibility relies in part on the capacity to maximize their photosynthetic, solar-to-biomass energy conversion efficiency. Here we show that cyanobacterial photosynthetic capacity can be increased by diverting cellular resources toward heterologous, energy-storing metabolic pathways and by reducing electron flow to photoprotective, but energy-dissipating, oxygen reduction reactions. We further show that these heterologous sinks can partially contribute to photosystem I (PSI) oxidation, suggesting an engineering strategy to improve both energy storage capacity and robustness by selective diversion of excess photosynthetic capacity to productive processes.