bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-Transition Consultations for Adolescents With Chronic Conditions in a General Pediatric Hospital: Lessons Learned
Authors: Mellerio Hélène , Dumas Agnès , Alberti Corinne , Guilmin-Crépon Sophie , Gastaldi Margaux , Passini Loïc , Gabarro Céline , Morsa Maxime , Roux Enora le , Jacquin Paul 
Published: May 2021

Abstract
The objective of the study was to assess the clinically relevant features of the pre-transition consultation (PTC) offered in AD’venir transition unit (R.Debré hospital, Paris) to all adolescents with a chronic condition.PTCs include a face-to-face interview with pediatricians trained in adolescent medicine, exploring the past (disease history), present (daily life, Treatment Burden Questionnaire, family/peer relationships, school, hobbies, sexuality, drugs) and future (global life project, transition, Good2Go questionnaire). Twenty-seven PTC recordings were qualitatively analyzed (girls=56%/median age=17.7yrs) within a multidisciplinary group (clinicians/sociologists/psychologist/public health researchers). Respectively 6-months and 2-years after PTC, benefits of PTC were assessed in referent healthcare providers (questionnaire) and in adolescents (phone interview). PTCs were a form of training for adult care, adolescents meeting a practitioner alone often for the first time. Naming their chronic condition was frequently difficult. All complained of limitations experienced in their social life (notably diet, tiredness, laboratory/medical appointments), but not treatment itself. Most were willing to talk about sexuality. Feelings concerning transition were various, with poor representations of adult healthcare. Transfer was often unplanned, but this did not influence transition readiness. After PTC, healthcare providers often changed their practices. Two years later, transition was successful for most of adolescents. ConclusionThe PTC is a relevant, easily implemented tool to help empower adolescents and customize their transition preparation within a holistic approach. A dedicated and long consultation, with an external/non-prescriber practitioner, including a physical examination are key factors promoting the establishment of trust, sharing of intimate issues and the assessment of potential barriers to transition.
High- Temperature Electrical Properties of Cerium Doped Ni-Zn Nano Ferrites
Authors: Nama Hari Kumar , Venkatesh N. , Ravinder Dachepalli , Batoo Khalid Mujasam , Raslan Emad H. , Hadi Muhammad 
Published: May 2021

Abstract
Rare Earth Ce3+ Substituted Nickel-Zinc Nano Ferrite were synthesized Calculated Chemical Formulation Ni0.2Zn0.8CexFe2-xO4 (0.000 ≤ x ≤ 0.040) by Citrate-Gel Auto Combustion method at lower temperature. The Single-Phase Cubic Spinel Structure was confirmed by the Characteristic of X-ray diffraction analysis (XRD). The SEM Micrographs confess from typical grain size and surface pattering of the samples is nanometric range confirming the nano crystalline nature. Energy Dispersive Spectrometer (EDS) were used to conduct elemental analysis and elemental parentage. Thermo electric power (TEP) of the prepared samples has been obtained using differential method with high temperature studies carried out in cooling cycle. The electric conductivity at high temperatures using two probe methods. The activation energy in the paramagnetic region (EP) is found greater than the ferrimagnetic region (EF). The carrier concentration(n), charge Carrier Mobility (μ) was carried out by TEP and electric conductivity Studies.
Metabolomic Signatures For Liver Tissue and Cecum Contents in High-Fat Diet-Induced Obese Mice Based on UHPLC-Q-TOF/MS
Authors: Cai Hongying , Wen Zhiguo , Meng Kun , Yang Peilong 
Published: May 2021

Abstract
Background: The incidence of obesity is increasing worldwide, and it is a risk factor for diabetes, dyslipidemia，and nonalcoholic fatty liver disease (NAFLD). Our previous study had demonstrated that high-fat diet induced increased weight gain, fat weight, serum cholesterol, triglyceride, and ATL levels in liver, and influenced the diversity and composition of cecal microbiota in mice. Hence, this study aimed to investigate the roles of the gut microbially derived metabolites and liver metabolites between the obese and lean mice, focusing on their association with the progression of obesity induced by high-fat diet (HFD).Methods: An obesity model in mice was established with HFD for 16 weeks. Cecal contents and liver tissues metabolomics based on ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) and orthogonal partial least squares discriminant analyses (OPLS-DA) was performed to identify the alterations in metabolites associated with obese mice. Results: Obese and lean groups were clearly discriminated from each other on OPLS-DA score plot and major metabolites contributing to the discrimination were mainly involved in glycerophospholipid metabolism, primary bile acid biosynthesis, and biosynthesis of unsaturated fatty acids pathways. HFD-induced alterations of 19 metabolites in liver and 43 metabolites in cecum contents were identified as potential biomarkers related to obesity. Specifically, chenodeoxycholic acid, taurochenodeoxycholate, and tauroursodeoxycholic acid in liver were elevated 35.94, 24.36, and 18.71-fold, respectively. PI(P-16:0/18:1(9Z)), PG(19:0/16:0), PS(P-16:0/20:2(11Z,14Z)), PI(22:1(11Z)/12:0), and PE(21:0/0:0) in cecum were enhanced 884, 640.96, 226.63, 210.10, 45.13-fold in comparison with the lean mice. These metabolites were the most important biomarkers for discriminating between the obese and lean mice. In addition, cecum contents metabolites were strongly correlated with hepatic metabolites through gut-liver axis analysis. Conclusions: HFD increased lipid profiles (i.e. glycerophospholipids, PC, PE, PI, PG, and PS) and total bile acid (primary and secondary bile acid) in liver and cecum, suggesting that they may play an important role in the progression of obesity. These metabolites can be used to better understand obesity and related disease induced by HFD. Furthermore, the level alterations of these metabolites can be used to assess the risk of obesity and the therapeutic effect of obesity management.
Selected ‘Starter Kit’ energy system modelling data for Guinea (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger 
Published: May 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to starting energy system modelling in developing countries, thereby causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Guinea, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and three stylized scenarios (Fossil Future, Least Cost and Net Zero by 2050) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Risk of Dementia in Patients with Toxoplasmosis- A Nationwide, Population-based Based Cohort Study in Taiwan
Authors: Yang Hung-Yi , Chien Wu-Chien , Chung Chi-Hsiang , Su Ruei-Yu , Lai Chung-Yu , Yang Chuan-Chi , Tzeng Nian-Sheng 
Published: May 2021

Abstract
Background

Toxoplasma gondii (T. gondii) has infected about 25–30% of individuals worldwide, and it was difficult to detect its latent status. We aimed to evaluate the association between toxoplasmosis, the risk of dementia, and the effects of antibiotics in Taiwan.
Material and methods

This nationwide, population-based, retrospective cohort study was conducted by using the two million Longitudinal Health Insurance Database retrieved from Taiwan’s National Health Insurance Research Database. The Fine and Gray’s competing risk analysis was used for the development of dementia in the toxoplasmosis cohort relative to the non-toxoplasmosis cohort. A sensitivity analysis was also conducted. The effects of the antibiotics (sulfadiazine or clindamycin) on the risk of dementia were also analyzed.
Results

We enrolled a total of 800 subjects, and identified 200 patients with toxoplasmosis and 600 sex- and age-matched controls without toxoplasmosis infections in a ratio of 1:3, selected between 2000 and 2015. The crude hazard ratio (HR) of the risk in the development of dementia was 2.570 (95% confidence interval [CI] = 1.511-4.347, p < 0.001). After adjusting for sex, age, monthly insurance premiums, urbanization level, geographic region, and comorbidities, the adjusted HR was 2.878 (95% CI = 1.709།4.968, p < 0.001). The sensitivity analysis revealed that toxoplasmosis was associated with the risk of Alzheimer and other degenerative dementia even after excluding the diagnosis of these two types of dementia in the first and first five years. The usage of the sulfadiazine or clindamycin in the treatment of toxoplasmosis was associated with a decreased risk of dementia.
Conclusion

This finding supports the evidence that toxoplasmosis is associated with dementia and the antibiotics treatment against toxoplasmosis is associated with a reduced risk of dementia. Further studies are necessary to explore the underlying mechanisms of these associations.
Immobilization of Spathaspora Passalidarum NRRL Y-27907 in Calcium Alginate Aiming the Production of Second-generation Ethanol
Authors: Silveira Juliane Machado da , Soares Lauren Bergmann , Cesca Karina , Silva Anderson Felipe Viana da , Longo Liana , Zanella Eduardo , Stambuk Boris U. , Biazi Luiz Eduardo , Ienczak Jaciane Lutz 
Published: May 2021

Abstract
The immobilization of S. passalidarum in calcium alginate beads for second-generation ethanol production (E2G) was evaluated in a medium that simulated a hemicellulosic hydrolysate of sugarcane bagasse pretreated with diluted sulfuric acid in terms of sugars composition. Three sets of sequential batch fermentations (SBF) were carried out with free cells, or immobilized cells in high (HSC) and moderate (MSC) initial sugar concentration (120 and 70 g/L, respectively). SBF were characterized by five consecutive batches performed in shaker, at 30 °C and 110 rpm. Better results were observed for the SBF with immobilized cells in MSC medium when compared to HSC (Y’P/S of 0.27 ± 0.02 and 0.19 ± 0.03 g/g, respectively), in the second batch cycle. The value for YP/S in MSC was similar to the obtained with free cells (0.30 ± 0.02 to 0.33 ± 0.02 g/g). However, QP was lower for MSC, reaching 0.81 ± 0.04 g/L.h in in the second batch, while for free cells the QP varied from 1.06 ± 0.02 to 1.16 ± 0.22 g/L.h. A technique for determining the concentration of immobilized cells in the alginate beads was applied, which made it possible to determine the specific rates for the SBF performed. According to the results obtained, it was possible to demonstrate that S. passalidarum can be immobilized in calcium alginate and reuse through SBF, with performance similar to free cells, which can be a good strategy for fermentation of hemicellulosic hydrolysates.
Surveying Family Access, Kangaroo Mother Care and Breastfeeding Policy Across NICUs in Italy
Authors: Artese Claudia , Ferrari Fabrizio , Perugi Silvia , Cavicchioli Paola , Paterlini Giuseppe , Mosca Fabio , Italy Developmental care Study Group SIN 
Published: May 2021

Abstract
BackgroundCurrently, there is a lack of data describing neonatal care in Italy, and the board of the Italian Society of Neonatology (SIN) is determined to promote a more active policy that favours family-centred developmental care. We aim to assess parental access to the NICUs, facilities offered to the family members, and to test “the state of art” regarding kangaroo maternal care (KMC) and breastfeeding policies in level III Italian NICUs. Methods A questionnaire both in paper and in electronic format was sent to all the 106 Italian level 3 NICUs; 86 NICUs (corresponding to the 80% units) filled out and sent the questionnaire back . The collected data were analysed; in addition a comparison between the 2017 survey and two previous survey related to the 2001-2006 data were performed in relation to the few items that had been answered by the two previous surveys.ResultsIn total, 62% of NICUs reported a free 24-hour access for both parents (vs 35% in 2001 and 32% in 2006). Parents were requested to leave temporarily the unit during shift changes, emergencies and medical round in 64% of the units. Some parental amenities, such as an armchair next to the cot (94%), a room for pumping milk and a waiting room were common, but others, such as a bed (16%) and accommodation (35%) were not. KMC was practiced in 94% of units but in most cases (62%) was limited to specific times. In 13% of NICUs, KMC was not offered to the father. The average duration of a KMC session, due to an estimation from the unit staff, was described to be longer in 24-h open NICUs than in limited access NICUs. Breast feading was successful in a small proportion of preterms staying in the NICU.Conclusion The number of 24-H open NICUs doubled over the last two decades. Some basic family facilities such as rooms with bed and shower for the parents remain uncommon. KMC and breastfeeding have become routine; however, the frequency and duration of KMC sessions reported by the NICUs professionals still do not meet the WHO recommendations.Trial RegistrationNot applicable
Low Density Neutrophils Are Increased in Patients With Behçet’s Disease but Do 3 Not Explain Differences in Neutrophil Function
Authors: Wallace Graham , Murad Mariam , Low Liying , Davidson Matthew , Murray Philip Ian , Rauz Saaeha 
Published: May 2021

Abstract
Objective Behçet’s disease (BD) is a multisystem autoinflammatory disease characterised by mucosal ulceration, ocular, neural, joint and skin inflammation. The cause of BD is not known but there is a strong genetic association with HLA-B*51, IL10 and IL23R. Neutrophils are a first line of defence against invading pathogens and have been described as activated in patients with BD. Neutrophils can now be separated into different subsets, such as low density (LDN) and normal density (NDN) that have diverse functional roles. We wished to address neutrophil heterogeneity in patients with BD. MethodsPeripheral blood neutrophils were obtained from 32 BD patients and 37 healthy aged-matched controls. Percoll isolation was used to isolate all neutrophils, while Ficol-Hypaque was used to obtain LDN and NDN. Phagocytic capacity and production of reactive oxygen species (ROS), and neutrophil extracellular traps (NET) stimulated with phorbol 12-myristate 13-acetate (PMA) and Escherichia coli (E.coli) were assessed in both groups. Results We have demonstrated reduced phagocytic capacity and ROS production but greater NET production by total neutrophils stimulated with PMA or E.coli from BD patients in comparison with healthy controls. Patients with BD had elevated numbers of LDN and lower number of NDN compared with healthy controls. However, both neutrophil subsets showed the same reduced ROS production and phagocytic function as total neutrophils in both 41 groups. Conclusion Our novel findings indicate that the neutrophil population in BD is heterogeneous and the increased number of LDN in combination with greater NET production may contribute to the inflammatory response and pathogenesis.
Modern Concept of Minimally Invasive Treatment of Military Personnel With Mandibular Fracture
Authors: Idashkina Natalia , Matros-Taranets Igor , Gudarian Оlexandr , Shepelia Аlla , Kinchur Hanna 
Published: May 2021

Abstract
Background: The treatment and rehabilitation of military servicemen with mandibular fractures at the hospital stage is an important medical, social and economic problem. Methods: A clinical study was conducted in 63 military servicemen with mandibular fractures, which injured during warfare in eastern Ukraine in the 2014-2019. The analysis of the potential use for the fragments intermaxillary fixation standard band splint vs the titanium pins and elastic traction for the treatment of mandibular fractures in military personnel has been carried out. Results: On the results of seven-year findings of administration in military servicemen injured during the hybrid war on the East of Ukraine, the advantages of using maxillomandibular fixation with screws for the treatment of mandibular fractures were illustrated.Conclusion: The operative treatment of mandibular fractures in military personnel preference should be given to method of maxillomandibular fixation with intermaxillary fixation screws, which provides with the high quality reposition and fixation. Trial registration: The work is a fragment of the research project of the Oral Surgery, Implantology and Periodontology Department of Dnipro State Medical University: «Development of methods for the prevention of complications in the treatment of inflammatory state and traumatic injuries in the maxillofacial area», state registration № 0113U005253 and applied research carried out in 2020-23 at the expense of the government funding "The prognosis, prevention and treatment of delayed union of bone tissue in patients with fractures of the jaws" № 0121U109420.
Reliability Evaluation of Functional Movement Screen for Prevention of Military Training Injury: A Prospective Study in China
Authors: Zeng Jing , Zhang Rong-Bing , Ke Jing-Jiu , Wu Xiang , Chen Li-Hua , Wang Yan-Yan , Xiao Jun 
Published: May 2021

Abstract
Background: Military training injury is a difficult problem in the field of military training. This study aimed to evaluate the effectiveness and feasibility of functional movement screen (FMS) evaluation system and individualized intervention measures in preventing military training injuries.Methods: A total of 420 recruits from a unit of the People's Liberation Army of China (PLA) were included as the research object. According to random grouping method, they were divided into observation group (Group A) and control group (Group B) , with 210 patients in each group. Before recruit training, individual FMS were performed, and functional correction training was performed in the observation group according to the test scores, while no intervention measures were applied in the control group. After three months of training, the tests were repeated. Age, body mass index (BMI) and incidence of military training injuries were recorded during the training period.Results: There was no statistical difference between the two groups in age, BMI, FMS score before the training (P > 0.05). After receiving functional correction training, the FMS score of the Group A was higher than that of the Group B, and the difference was statistically significant (P < 0.05). The incidence of military training injury in Group A and Group B was 20.95% and 44.02%, respectively (P < 0.05), and the difference was statistically significant.Conclusion: The evaluation system of FMS and individualized intervention measures are feasible and effective in predicting and reducing the occurrence of military training injuries.
The Protective of hUC- MSCs Derived Exosomes on Pulmonary Vascular Remodeling in Experimental Pulmonary Hypertension
Authors: Jiang Wan , Liu Xiaoli , Li Susu , Wang Junfu , Li Kailin , Xin Qian , Wang Jue , Sun Chao , luan yun 
Published: May 2021

Abstract
Pulmonary hypertension (PH) is a life-threatening disease, so far no effective method for it. Therefore, the main aim of the present study was to investigate the protective effect of exosomes derived from human umbilical cord msenchymal stem cells (hUC-MSCs) on PH vascular remodeling and reveal the underlying mechanism. We established monocrotaline-induced PH (MCT-PH) rats and hypoxia induced pulmonary artery smooth muscle cells (H-PASMC) model in vivo and vitro . Exosomes derived from hUC-MSCs (hUC-MSC-EXO) were administration, respectively. Post-operation, our results showed that hUC-MSC-EXO significantly reduced the right ventricular systolic pressure (RVSP) and the right ventricular hypertrophy index (RVHI), inhibited pulmonary vascular remodeling. Furthermore, the hypoxia-induced PASMC proliferation was obviously inhibited in vitro . More-importantly, the results showed that the protein expression levels of BMPR2, BMP-4 and BMP-9 were significantly increased, but the levels of nuclear factor-κB (NF-κB) p65 and bone morphogenetic protein (BMP) antagonists Gremlin-1 were significantly decreased in hUC-MSC-EXO than that in MCT-PH and hypoxia-induced PASMC groups in vivo and vitro , respectively. Taken together, this present study provided the firm information for the use of this new method in treatment of PH, and the mechanism was associated with regulation of BMP signaling pathway.
Culture, Innovation and Economic Development
Authors: Kostis Pantelis C. 
Published: May 2021

Abstract
During recent decades, culture is gaining more and more attention as a factor that determines economic outcomes. Trying to investigate its role on innovation and economic development, this paper uses a dataset that offers the potential for a cross sectional and time series analysis. Thus, in this paper the effects of culture on innovation (as measured by patent applications, spending on R&D, number or researchers per 1,000 individuals and number of Government researchers) and economic development are investigated. Cultural background is captured through the Schwartz’s cultural values, as reported through the European Social Survey (ESS) waves during the period 2002- 2018. The dataset is comprised by 18 Eurozone countries. Using Principal Component Analyses to capture the Schwartz’s cultural values, as well as two ways fixed effects analysis (FE), time dummies for each ESS wave included in the analysis and cluster - robust estimates of the standard errors, in order to examine the above relationships, the main conclusions derived from the analysis are that: a) there is significant effect of culture on innovation and economic development, and b) the main cultural dimensions that hinder innovation and economic development are the prevalence of hierarchy, affective autonomy, and mastery. These results hold for all different dependent variables used in the analysis. Thus, when hierarchy, affective autonomy, and mastery are present innovation and economic development are hindered, leading to obstacles regarding the sustainability of economic outcomes. The opposite holds in societies where embeddedness, egalitarianism and harmony prevail.