bluuebunny/crossref_metadata_2025_split huggingface dataset:
Context counts: a qualitative study exploring the interplay between context and implementation success
Authors: Rogers Lisa , De Brún Aoife , Birken Sarah A. , Davies Carmel , McAuliffe Eilish 
Published: March 2021

PurposeImplementing change in healthcare is difficult to accomplish due to the unpredictability associated with challenging the status quo. Adapting the intervention/practice/program being implemented to better fit the complex context is an important aspect of implementation success. Despite the acknowledged influence of context, the concept continues to receive insufficient attention at the team-level within implementation research. Using two heterogeneous multidisciplinary healthcare teams as implementation case studies, this study evaluates the interplay between context and implementation and highlights the ways in which context influences the introduction of a collective leadership intervention in routine practice.Design/methodology/approachThe multiple case study design adopted, employed a triangulation of qualitative research methods which involved observation (Case A = 16 h, Case B = 15 h) and interview data (Case A = 13 participants, Case B = 12 participants). Using an inductive approach, an in-depth thematic analysis of the data outlined the relationship between team-level contextual factors and implementation success.FindingsThemes are presented under the headings: (1) adapting to the everyday realities, a key determinant for implementation success and (2) implementation stimulating change in context. The findings demonstrate a dynamic relationship between context and implementation. The challenges of engaging busy healthcare professionals emphasised that mapping the contextual complexity of a site and adapting implementation accordingly is essential to enhance the likelihood of successful implementation. However, implementation also altered the surrounding context, stimulating changes within both teams.Originality/valueBy exposing the reciprocal relationship between team-level contextual factors and implementation, this research supports the improved design of implementation strategies through better understanding the interplay and mutual evolution of evidence-based healthcare interventions within different contexts.
Examining the extent of and drivers for materiality assessment disclosures in sustainability reports
Authors: Farooq Muhammad Bilal , Zaman Rashid , Sarraj Dania , Khalid Fahad 
Published: March 2021

Purpose
This paper aims to evaluate the extent of materiality assessment disclosures in sustainability reports and their determinants. The study examines the disclosure practices of listed companies based in the member states of the Cooperation Council for the Arab States of the Gulf, colloquially referred to as the Gulf Cooperation Council (GCC).

Design/methodology/approach
First, the materiality assessment disclosures were scored through a content analysis of sustainability reports published by listed GCC companies during a five-year period from 2013 to 2017. Second, a fixed effect ordered logic regression was used to examine the determinants of materiality assessment disclosures.

Findings
While sustainability reporting rates improved across the sample period, a significant majority of listed GCC companies do not engage in sustainability reporting. The use of internationally recognised standards has also declined. While reporters provide more information on their materiality assessment, the number of sustainability reports that offer information on how the reporter identifies material issues has declined. These trends potentially indicate the existence of managerial capture. Materiality assessment disclosure scores are positively influenced by higher financial performance (Return on Assets), lower leverage and better corporate governance. However, company size and market-to-book ratio do not influence materiality assessment disclosures.

Practical implications
The findings may prove useful to managers responsible for preparing sustainability reports who can benefit from the examples of materiality assessment disclosures. An evaluation of the materiality assessment should be included in the scope of assurance engagements and practitioners can use the examples of best practice when evaluating sustainability reports. Stock exchanges may consider developing improved corporate governance guidelines as these will lead to materiality assessment disclosures.

Social implications
The findings may assist in improving sustainability reporting quality, through better materiality assessment disclosures. This will allow corporate stakeholders to evaluate the reporting entities underlying processes, which leads to transparency and corporate accountability. Improved corporate sustainability reporting supports the GCC commitment to implement the United Nations Sustainable Development Goals and transition to sustainable development.

Originality/value
This study addresses the call for greater research examining materiality within a sustainability reporting context. This is the first paper to examine sustainability reporting quality in the GCC region, focussing particularly on materiality assessment disclosures.
Does knowledge hiding undermine buyer-supplier relationship performance in supply chains? A dyadic perspective
Authors: Butt Atif Saleem , Shah Syed Hamad Hassan , Ahmad Ahmad Bayiz 
Published: March 2021

Purpose
The purpose of this paper is to explore how knowledge hiding affects buyer-supplier relationship performance in the supply chain.

Design/methodology/approach
This study uses a multiple case study methodology. Overall, 26 semi-structured interviews (13 dyadic interviews) with managers of buying and supplying firms (who have been a victim of knowledge hiding) were undertaken.

Findings
Based on comprehensive data analysis, results reveal seven factors that adversely affect buyer-supplier relationship performance (lack of trust, lack of cooperation and lack of commitment). In addition, results reveal that such factors reduced the firm’s business performance in terms of low-quality products, increased lead time and higher costs.

Research limitations/implications
This study has some limitations. First, the results of this study are not generalizable to a broader population. Second, this study explores behavioral patterns with respect to United Arab Emirates culture only.

Practical implications
Firms can use the findings from this study to understand how knowledge hiding in a buyer-supplier relationship adversely affects a buyer-supplier relationship performance.

Originality/value
A considerable weakness in buyer-supplier relationship literature is a need for a study examining how knowledge hiding harms buyer-supplier relationship performance in the supply chain. This paper addresses this gap.
Influence of information and communication technologies on customer satisfaction and increase in the number of customers
Authors: Acosta-Prado Julio César , Tafur-Mendoza Arnold Alejandro 
Published: March 2021

Purpose
Information and communication technologies (ICT) play an important role in business management today. However, there is little information on how the uses of ICT within firms create positive results regarding service. The purpose of the study is to know the degree of influence of ICT on customer satisfaction and increase in the number of customers.

Design/methodology/approach
The sample consisted of 102 Colombian new technology-based firms (NTBFs) located in business incubators and technology parks, selected through a non-probabilistic, purposeful sampling. To perform the statistical analysis, structural equation modeling was used.

Findings
The results indicated a good fit of the proposed model, where ICT have a positive and significant influence with a medium effect on customer satisfaction and a large effect on increase in the number of customers. The findings showed that the implementation of ICT in the different internal processes of NTBFs favors external processes, to improve and innovate the quality of their service, reflecting in a positive perception of customers.

Originality/value
Influence of ICT on the performance of firms has not been widely studied in non-economic results. The internal processes of the firms are the use of internet technologies, collaboration, management, decision-making support, search and data management. Meanwhile, external processes involve services directly visible to customers. Previous research does not consider the impact of ICT on internal processes that have repercussions on external processes.
Population risk factors for nulliparous, term, singleton, vertex caesarean birth: a national cross‐sectional study
Authors: Andrikopoulou M , Wen T , Sheen J‐J , Krenitsky N , Baptiste CD , Goffman D , Staniczenko AP , D’Alton ME , Friedman AM 
Published: March 2021

ObjectiveTo characterise medical, obstetric and demographic risk factors associated with nulliparous, term, singleton, vertex (NTSV) caesarean birth.Study designCross‐sectional study.SettingUnited States delivery hospitalisations.PopulationNTSV births in 2016–18 US natality data.MethodsThis study analysed a national sample of natality data generated by the United States National Vital Statistics System. NTSV deliveries were identified. The primary outcome was caesarean birth. Risk factors including maternal age, body mass index (BMI) and pregestational diabetes were analysed. Multivariable log‐linear regression models analysed factors associated with NTSV caesarean with adjusted risk ratios (aRR) as measures of effect.ResultsOf 11 622 400 deliveries, 3 764 707 met NTSV criteria, and their caesarean section rate was 25.9%. Maternal age 35–39 years (aRR 1.51, 95% CI 1.50–1.52) and 40–54 years (aRR 2.03, 95% 2.00–2.05) compared with age 19–34 years; BMI 25 to <30 kg/m2 (aRR 1.32, 95% CI 1.31–1.33), 30 to <35 kg/m2 (aRR 1.57 95% CI 1.56–1.58), 35 to <40 kg/m2 (aRR 1.82, 95% CI 1.80–1.83) and ≥40 kg/m2 (aRR 2.17, 95% CI 2.15–2.19) compared with BMI 18.5–24.9 kg/m2; and pregestational diabetes (aRR 1.54, 95% CI 1.51–1.57) were all associated with increased risk. Risk factors allowed stratification of patients into high‐risk versus low‐risk groups. The NTSV caesarean rate was 37.9% in women who had one or more of the following characteristics: age ≥35 years, BMI ≥30 kg/m2 or pregestational diabetes. In comparison, the NTSV caesarean rate was 20.8% among women without any of these three risk factors (P < 0.01).ConclusionAmong NTSV births, BMI, maternal age and medical conditions are important risk factors for caesarean delivery.
Comparing footwear impressions that are close non‐matches using correlation‐based approaches
Authors: Venkatasubramanian Gautham , Hegde Vighnesh , Padi Sarala , Iyer Hari , Herman Martin 
Published: March 2021

AbstractForensic activities related to footwear evidence may be broadly classified into the following two categories: (1) intelligence gathering and (2) evidential value assessment. Intelligence gathering provides additional leads for investigators. Assessment of evidential value, as practiced in the United States, involves a trained footwear examiner evaluating the degree of similarity between a known shoe of interest (together with its test impressions) and footwear impressions obtained from a crime scene, by performing side‐by‐side visual comparisons. However, the need for developing quantitative approaches for expressing similarities during such comparisons is being increasingly recognized by the forensic science community. In this paper, we explore the ability of similarity metrics to discriminate between impressions made by a shoe of interest and impressions made by close non‐matching shoes. Close non‐matching shoes largely share the same design and size. Therefore, the ability to effectively discriminate between them requires considering, either explicitly or implicitly, not only design and size, but also wear patterns and, to some extent, individual characteristics. This type of discrimination is necessary for assessment of evidential value. The similarity metrics examined in this paper are correlation‐based metrics, including normalized cross‐correlation, phase‐only correlation, AvNCC, and AvPOC. The latter two metrics are based on features obtained from a convolutional neural network. Experiments are performed using Everspry impressions, FBI boot impressions, and the West Virginia University footwear impression collection. The results show that phase‐only correlation performs as well as or better than the other metrics in all cases for the datasets we considered.
Redesign of ultrasensitive and robust RecA gene circuit to sense DNA damage
Authors: Chen Jack X. , Lim Boon , Steel Harrison , Song Yizhi , Ji Mengmeng , Huang Wei E. 
Published: March 2021

SummarySOS box of the recA promoter, PVRecA from Vibrio natriegens was characterized, cloned and expressed in a probiotic strain E. coli Nissle 1917. This promoter was then rationally engineered according to predicted interactions between LexA repressor and PVRecA. The redesigned PVRecA‐AT promoter showed a sensitive and robust response to DNA damage induced by UV and genotoxic compounds. Rational design of PVRecA coupled to an amplification gene circuit increased circuit output amplitude 4.3‐fold in response to a DNA damaging compound mitomycin C. A TetR‐based negative feedback loop was added to the PVRecA‐AT amplifier to achieve a robust SOS system, resistant to environmental fluctuations in parameters including pH, temperature, oxygen and nutrient conditions. We found that E. coli Nissle 1917 with optimized PVRecA‐AT adapted to UV exposure and increased SOS response 128‐fold over 40 h cultivation in turbidostat mini‐reactor. We also showed the potential of this PVRecA‐AT system as an optogenetic actuator, which can be controlled spatially through UV radiation. We demonstrated that the optimized SOS responding gene circuits were able to detect carcinogenic biomarker molecules with clinically relevant concentrations. The ultrasensitive SOS gene circuits in probiotic E. coli Nissle 1917 would be potentially useful for bacterial diagnosis.
The role of EGFR‐TKIs as adjuvant therapy in EGFR mutation‐positive early‐stage NSCLC: A meta‐analysis
Authors: Lin Chutong , Hu Fengling , Chu Hongling , Ren Peng , Ma Shanwu , Wang Jingdi , Bai Jie , Han Xuan , Ma Shaohua 
Published: March 2021

AbstractBackgroundThe role of adjuvant epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) is not clear in early‐stage nonsmall‐cell lung cancer (NSCLC) patients. This meta‐analysis aims to compare the efficacy and safety of EGFR‐TKIs as adjuvant therapy with chemotherapy or placebo in NSCLC patients harboring EGFR mutations.Patients and MethodsPubmed, Embase, and Cochrane databases were searched for randomized controlled trials. The hazard ratio (HR) of disease‐free survival (DFS) and overall survival (OS) as well as the risk ratio (RR) of severe adverse events were merged.ResultsSeven articles from five studies from 1843 records, a total of 1227 patients, were included in the analysis. The HR for DFS was 0.38 (95% confidence interval [CI] 0.22–0.63), in favor of EGFR‐TKIs. However, no significant benefit of OS was seen (HR = 0.61, 95% CI 0.31–1.22). Treatment benefit was more pronounced in patients with advanced disease stage and longer duration of medication, EGFR exon 19 deletion mutation, and treatment with third‐generation EGFR‐TKIs. Adjuvant targeted therapy may cause few adverse events compared with chemotherapy (RR = 0.28, 95% CI 0.09–0.94). The possibility of severe adverse events for the first‐generation drugs was significantly lower than for third‐generation drugs.ConclusionIn EGFR mutation‐positive patients with stage IB–IIIA NSCLC, compared with adjuvant chemotherapy or placebo, adjuvant EGFR‐TKIs should effectively improve the patient's DFS, but not effectively improve OS. Disease stage, treatment duration, mutation types, and therapeutic drugs could affect the degree of benefit. Adjuvant EGFR‐TKIs had more favorable tolerability than chemotherapy, especially with the usage of first‐generation drugs.
Short‐Termist CEO Compensation in Speculative Markets: A Controlled Experiment*
Authors: Chang Yen‐Cheng , Huang Minjie , Su Yu‐Siang , Tseng Kevin 
Published: March 2021

ABSTRACTBolton, Scheinkman, and Xiong (2006) model a setting where investors disagree and short‐sales constraints cause pessimistic views of stock prices to be less influential, which leads to speculative stock prices. A theoretical implication of the model is that existing shareholders can exploit the speculative stock prices by (i) designing managerial compensation contracts that encourage short‐term performance, and (ii) subsequently selling their shares to more optimistic investors. We document empirical support for this theory by finding that an exogenous removal (Regulation SHO) of short‐sales constraints curbs the provision of short‐term incentives, an effect reflected in longer CEO compensation duration. The effect is concentrated among stocks with high investor disagreement and short‐term‐oriented institutional ownership. Consistent with prior work, we also find that longer CEO compensation duration leads to longer CEO investment horizons, less overinvestment, and less earnings management. Collectively, our results speak to the contributing role of speculative stock prices in corporate short‐termism. Finally, our study implies that effective policies to curb corporate short‐termism should address stock market speculation and promote mechanisms that tie executive compensation to longer‐term stock price performance.
Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease
Authors: Wang Jiangong , Liu Bin , Xu Yong , Yang Meizi , Wang Chaoyun , Song Mengmeng , Liu Jing , Wang Wentao , You Jingjing , Sun Fengjiao , Wang Dan , Liu Dunjiang , Yan Haijing 
Published: March 2021

AbstractAlzheimer's disease (AD) is an age‐related neurodegenerative disease, and the imbalance between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis. Autophagy is an intracellular degradation pathway whereby leads to removal of aggregated proteins, up‐regulation of which may be a plausible therapeutic strategy for the treatment of AD. Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative feedback way. Our previous study showed that thioperamide, as an antagonist of H3R, enhances autophagy and protects against ischemic injury. However, the effect of thioperamide on autophagic function and Aβ pathology in AD remains unknown. In this study, we found that thioperamide promoted cognitive function, ameliorated neuronal loss, and Aβ pathology in APP/PS1 transgenic (Tg) mice. Interestingly, thioperamide up‐regulated autophagic level and lysosomal function both in APP/PS1 Tg mice and in primary neurons under Aβ‐induced injury. The neuroprotection by thioperamide against AD was reversed by 3‐MA, inhibitor of autophagy, and siRNA of Atg7, key autophagic‐related gene. Furthermore, inhibition of activity of CREB, H3R downstream signaling, by H89 reversed the effect of thioperamide on promoted cell viability, activated autophagic flux, and increased autophagic‐lysosomal proteins expression, including Atg7, TFEB, and LAMP1, suggesting a CREB‐dependent autophagic activation by thioperamide in AD. Taken together, these results suggested that H3R antagonist thioperamide improved cognitive impairment in APP/PS1 Tg mice via modulation of the CREB‐mediated autophagy and lysosomal pathway, which contributed to Aβ clearance. This study uncovered a novel mechanism involving autophagic regulating behind the therapeutic effect of thioperamide in AD.
Efficacy and safety of treatment with biologicals for severe chronic rhinosinusitis with nasal polyps: A systematic review for the EAACI guidelines
Authors: Agache Ioana , Song Yang , Alonso‐Coello Pablo , Vogel Yasmin , Rocha Claudio , Solà Ivan , Santero Marilina , Akdis Cezmi A. , Akdis Mubeccel , Canonica Giorgio Walter , Chivato Tomas , del Giacco Stefano , Eiwegger Thomas , Fokkens Wytske , Georgalas Christos , Gevaert Philippe , Hopkins Claire , Klimek Ludger , Lund Valerie , Naclerio Robert , O'Mahony Liam , Palkonen Susanna , Pfaar Oliver , Schwarze Jürgen , Soyka Michael B. , Wang De Yun , Zhang Luo , Canelo‐Aybar Carlos , Palomares Oscar , Jutel Marek 
Published: March 2021

AbstractThis systematic review evaluates the efficacy and safety of biologicals for chronic rhinosinusitis with nasal polyps (CRSwNP) compared with the standard of care. PubMed, Embase, and Cochrane Library were searched for RCTs. Critical and important CRSwNP‐related outcomes were considered. The risk of bias and the certainty of the evidence were assessed using GRADE. RCTs evaluated (dupilumab‐2, omalizumab‐4, mepolizumab‐2, and reslizumab‐1) included 1236 adults, with follow‐up of 20–64 weeks. Dupilumab reduces the need for surgery (NFS) or oral corticosteroid (OCS) use (RR 0.28; 95% CI 0.20–0.39, moderate certainty) and improves with high certainty smell evaluated with UPSIT score (mean difference (MD) +10.54; 95% CI +9.24 to +11.84) and quality of life (QoL) evaluated with SNOT‐22 (MD −19.14; 95% CI −22.80 to −15.47), with fewer treatment‐related adverse events (TAEs) (RR 0.95; 95% CI 0.89–1.02, moderate certainty). Omalizumab reduces NFS (RR 0.85; 95% CI 0.78–0.92, high certainty), decreases OCS use (RR 0.38; 95% CI 0.10–1.38, moderate certainty), and improves high certainty smell (MD +3.84; 95% CI +3.64 to +4.04) and QoL (MD −15.65; 95% CI −16.16 to −15.13), with increased TAE (RR 1.73; 95% CI 0.60–5.03, moderate certainty). There is low certainty for mepolizumab reducing NFS (RR 0.78; 95% CI 0.64–0.94) and improving QoL (MD −13.3; 95% CI −23.93 to −2.67) and smell (MD +0.7; 95% CI −0.48 to +1.88), with increased TAEs (RR 1.64; 95% CI 0.41–6.50). The evidence for reslizumab is very uncertain.