bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Bovine Trypanosomosis and Its Associated Risk Factor in Hawa Galan District, Kelem Wollega Zone of Ethiopia
Authors: Tsegaye Girma , Abebe Belay , Haile Geremew 
Published: November 2021

An analytical cross-sectional study was performed between November 2015 and April 2016 at Hawa Galan woreda, Kelem Wollega Zone, Oromia Region, Ethiopia, to estimate the proportion of cattle with trypanosomosis and to evaluate the elements associated with the prevalence of bovine trypanosomosis. A haemoparasitological examination of the Buffy coat method was implemented to determine the proportion of trypanosomosis-positive cattle. A study population of 428 bovines was randomly selected from three peasant associations (PAs) and tested for the presence of the disease. Findings of the laboratory results indicate that among all animals tested at the study time, 26 (6%) animals were positive for the disease. Among the positive results, the proportion of trypanosome species was Trypanosoma congolense 18 (69.3%) and Trypanosoma vivax 8 (30.7%). The prevalence at the selected PAs was 12.5%, 3.8%, and 3% for Lemlem, Madawalkituma, and Ifajiru, respectively. From this finding, the relationship has a statistically significant variation (

P

< 0.05) among peasant associations and body condition state, and the proportion was significantly greater (

P

< 0.05) in animals categorized under poor body condition score. The relationships between age and sex of cattle show no statistically significant variation among them (

P

> 0.05). This study indicates that the proportion of trypanosomosis was greater in anemic (PCV<24%) cattle than nonanemic (PCV≥24%). Therefore, based on this finding, the proportion of bovine trypanosomosis is evident that can cause a major effect on the health of cattle in the study population in the study area. So, effective control methods could be applied to decrease the disease and its related economic loss.
The Power of Bipartisan Mobilization: The Success of Tunisia’s Feminist Movement During the Coronavirus Pandemic
Authors: Youssef Maro , Yerkes Sarah 
Published: November 2021

Abstract
The Tunisian government, which is deeply divided, especially along ideological lines, responded to growing concerns over increased violence against women during the Coronavirus pandemic by establishing a new domestic violence shelter and 24/7 hotline. This article asks: Why did the state respond to gender-based violence(gbv) concerns during the Coronavirus pandemic in Tunisia, despite ideological and political divisions? We argue that the state addressed some concerns around violence during the pandemic because combatting gbv has bipartisan support in Tunisia. Tunisian Islamist and secularist women’s rights organizations succeeded in building a bipartisan coalition of support on this issue because they worked either together in a short-lived coalition or in tandem with similar goals over the past decade during the democratic transition in Tunisia. Building on the existing coalition literature, we show that feminist coalition formation before a pandemic has implications for feminists’ success in times of crisis.
Umbrian ⟨rs⟩ and ⟨rf⟩
Authors: Onishi Teigo 
Published: November 2021

Abstract
This paper examines two different outcomes of reconstructed *rs sequences in Umbrian. While the sequence *rs which goes back to Proto-Sabellic is continued as ⟨rs⟩,secondary *rs that developed from *rVs by syncope or from *rtt by assibilation and degemination is written as ⟨rf⟩.A synchronic and diachronic analysis of these different outcomes is provided.It is argued that the key conditioning factor for the different outcomes is not whether *rs was diachronically original, but whether *s in *rs formed a simple onset.
Development of a Field-Based Chemistry Experiment Teaching Model to Strengthen Pre-Service Teachers’ Competence for Teaching Chemistry Experiments
Authors: Bae Sung Woo , Lee Jae Hwan , Park Jongseok 
Published: November 2021

Abstract
The FCE (field-based chemistry experiment) model was developed to cultivate pre-service science teachers’ ability to teach chemistry experiments in secondary classrooms. We describe the process of developing the FCE model and student activities via feedback from experts and analysis of the implemented program. This study evaluated the effectiveness of implementing the FCE model with 58 pre-service science teachers to examine how this model impacts on the role of the instructor and students. Implementation impact was examined by analyzing qualitative data from surveys and observations of student activities. The FCE model minimized the role of the instructor by using flipped learning and cooperative learning, which enabled learners to construct class contents by themselves with topics aligned to the secondary science curriculum. Findings suggest the FCE model supports pre-service science teachers to acquire both knowledge and practical skills related to conducting and teaching experiments. Implications for pre-service science teacher preparation are discussed.
Pre-contractual relational governance for public–private partnerships: how can ex-ante relational governance help formal contracting in smart city outsourcing projects?
Authors: Mu Rui , Wu Peiyi , Haershan Maidina 
Published: November 2021

In the literature on relational governance, it is often assumed that relational governance emerges primarily after formal contracting and acts as a functional supplement to a formal contract. In this article, we show that especially facing deep uncertainties, relational governance can emerge before the start of formal partnerships, in the form of trust-building, exchanging resources, and fostering flexibility. Based on a case study of a smart city outsourcing project, this article introduces a forward-extended framework of relational governance that captures the pre-contractual dimensions of relationship cultivation and their role in facilitating formal contracting. The study finds that pre-contractual relational governance facilitates formal contracting by reducing substantive, evaluative, technological, and procedural uncertainties in the project and helps the partners to design an elaborative contract, undergo an easy negotiation, adopt short-term contracts, and use simple monitoring and evaluation methods. The article thus argues that only understanding post-contractual relational governance is insufficient for exploring the relation between formal contracting and relational governance; facing deep uncertainties, it is necessary to understand how public and private parties develop their pre-contractual relationship and reduce the uncertainties before a formal contract can be signed. Points for practitioners Practitioners should realize that there is much room for relational governance in the pre-contractual phase of PPP projects when the projects are rife with various uncertainties. Public and private parties can take measures to build trust, foster flexibility, and create interdependence before a formal contract is signed. These ex-ante relational governance measures can facilitate formal contracting by reducing the various uncertainties, making a formal contract designable, making negotiation smooth and easy, and reducing the need for contract supervision.
The key role of pulse wave transit time to predict blood pressure variation during anaesthesia induction
Authors: Hu Guoqiang , Chen Minjuan , Wang Xiaodan , Chen Lingyang , Wang Weijian 
Published: November 2021

Objective To establish the relationship between pulse wave transit time (PWTT) before anaesthesia induction and blood pressure variability (BPV) during anaesthesia induction. Methods This prospective observational cohort study enrolled consecutive patients that underwent elective surgery. Invasive arterial pressure, electrocardiography, pulse oximetry, heart rate and bispectral index were monitored. PWTT and BPV were measured with special software. Anaesthesia was induced with propofol, sufentanil and rocuronium. Results A total of 54 patients were included in this study. There was no correlation between BPV and the dose of propofol, sufentanil and rocuronium during anaesthesia induction. Bivariate linear regression analysis demonstrated that PWTT ( r = –0.54), age ( r = 0.34) and systolic blood pressure ( r = 0.31) significantly correlated with systolic blood pressure variability (SBPV). Only PWTT ( r = –0.38) was significantly correlated with diastolic blood pressure variability (DBPV). Patients were stratified into high PWTT and low PWTT groups according to the mean PWTT value (96.8 ± 17.2 ms). Compared with the high PWTT group, the SBPV of the low PWTT group increased significantly by 3.4%. The DBPV of the low PWTT group increased significantly by 2.1% compared with the high PWTT group. Conclusions PWTT, assessed before anaesthesia induction, may be an effective predictor of haemodynamic fluctuations during anaesthesia induction.
The Hatnub Quarries Industrial Landscape Survey 2017: Mobile-GIS Ground-truthing of the Satellite Remote-survey
Authors: Pethen Hannah 
Published: November 2021

This paper presents the results of the 2017 mobile-GIS survey of 1 km2 around the Hatnub Egyptian alabaster quarries and analysis of the accuracy of the remote-survey of the same area, which was completed in 2016 using satellite imagery. The analysis revealed that remote-survey was a very accurate method for recording archaeological features in clear and unobstructed parts of the desert, while targeted mobile-GIS survey of obscure areas and questionable features was an effective method for reducing inaccuracies in remote-survey data. The results will inform future phases of the Hatnub Industrial Landscape Project and the fieldwork also identified several avenues of future research into routes and roads across the desert.
Health Care Providers’ Knowledge, Attitudes, and Practices and the Association With Referrals to the National Diabetes Prevention Program Lifestyle Change Program
Authors: Hulbert LaShonda R. , Zhang Xuanping , Ng Boon Peng , Nhim Kunthea , Khan Tamkeen , Cannon Michael J. 
Published: November 2021

Purpose To examine how health care providers’ knowledge, attitudes, and practices affect their referrals to the National Diabetes Prevention Program. Design Cross-sectional, self-report data from DocStyles—a web-based survey Setting USA Sample Practicing family practitioners, nurse practitioners, pharmacists, and internists, n = 1,503. Measures Questions regarding health care providers’ knowledge, attitudes, and practices and their referrals to the National Diabetes Prevention Program. Analysis Bivariate and multivariate analyses were used to calculate predictive margins and the average marginal effect. Results Overall, 15.2% of health care providers ( n = 1,503) reported making a referral to the National Diabetes Prevention Program. Health care providers were more likely to make referrals if they were familiar with the program (average marginal effect = 36.0%, 95% CI: 29.1%, 42.8%), reported knowledge of its availability (average marginal effect=49.1%, 95% CI: 40.2%, 57.9%), believed it was important to make referrals to the program (average marginal effect = 20.7%, 95% CI: 14.4%, 27.0%), and used electronic health records to manage patients with prediabetes (average marginal effect = 9.1%, 95% CI: 5.4%, 12.7%). Health care providers’ demographic characteristics had little to no association with making referrals. Conclusion Making referrals to the National Diabetes Prevention Program was associated with health care providers’ knowledge of the program and its reported availability, their attitudes, and their use of the electronic health record system to manage patients with prediabetes.
Daratumumab-based therapies in transplant-ineligible patients with untreated multiple myeloma and hepatic dysfunction: A systematic review of subgroup analyses
Authors: Gil-Sierra Manuel David , Briceño-Casado Maria del Pilar , Fénix-Caballero Silvia , Alegre-Del Rey Emilio Jesús , de la Lastra-Romero Catalina Alarcón , Sánchez-Hidalgo Marina 
Published: November 2021

Introduction There is subgroup analysis suggesting a lack of benefit of daratumumab use in multiple myeloma (MM) and hepatic disease (HD). The objectives of this study were to conduct a systematic review and interpretation of daratumumab-based regimen efficacy in transplant-ineligible patients with untreated MM and HD. Methods A systematic search in Pubmed® database about randomized clinical trials (RCTs) with subgroup analysis regarding hepatic function for overall survival (OS) or progression-free survival (PFS) were developed. Two methodologies were applied. One of them considered statistical interaction, prespecification, biological support and consistency of subgroup results. Second methodology was two-part validated tool: preliminary questions to reject subset analysis without minimal relevance, and a checklist relating a recommendation for applicability in clinical practice. Results It was included three records. About first methodology, statistical interaction among subgroups was found for PFS in one RCT. Subsets were prespecified in all RCTs. Biological support of efficacy differences could be reasonable. Inconsistent results were found. Second methology directly rejected applicability of subset analysis in two records. Checklist recommended “null” application of results in the remaining RCT. Conclusions No consistent heterogeneity for daratumumab-based regimen efficacy was observed among subgroups regarding hepatic function in transplant-ineligible patients with untreated MM. Patients with normal hepatic function and HD could benefit from these treatments.
Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report
Authors: Banerjee Rahul , Lo Mimi , Klein Liviu , Aras Mandar , Logan Aaron C. 
Published: November 2021

Introduction For young adult patients with acute leukemia, both the efficacy and cardiotoxicity of anthracycline-based regimens have been documented. We report the case of a patient with severe cardiomyopathy, mechanically supported by a left ventricular assist device (LVAD), who subsequently developed Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph + ALL). To our knowledge, this is the first report of anthracycline administration in a patient with heart failure requiring mechanical support. Case report Our 27-year-old female patient was diagnosed with Ph + B-ALL as part of workup for leukocytosis. Past medical history included non-ischemic cardiomyopathy with a left ventricular ejection fraction of 30–35% and moderate-severe right ventricular dysfunction, for which LVAD had been placed 4 years previously. Management & outcome After shared decision-making and multidisciplinary discussions, we felt that hyperfractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone alternating with cytarabine and high-dose methotrexate in addition to ponatinib (HyperCVAD-ponatinib) best balanced the patient's goals for aggressive treatment with the potential for rapid and durable remissions. The patient received a single reduced dose of doxorubicin alongside dexrazoxane with her first cycle of HyperCVAD-ponatinib. She attained a complete molecular response 22 days later and remains in remission (with stable cardiac function) 30 months later on maintenance therapy. Discussion In conclusion, LVAD placement is not an absolute contra-indication to anthracyclines if such therapies offer the best opportunity for a durable response.
Corneal Surgery in the Cat: Diseases, considerations and techniques
Authors: Telle Mary Rebecca , Betbeze Caroline 
Published: November 2021

Practical relevance: The ability to recognize, diagnose and treat corneal disease is essential for maintaining vision and comfort in feline patients. Being able to correctly identify appropriate techniques for surgical cases is of particular importance for success when performing corneal surgery. Clinical challenges: Many different corneal diseases present with similar clinical signs, and it can be hard to determine the appropriate treatment for individual patients. It is essential for the clinician to understand the indications for corneal surgery, instrumentation needed and microsurgical principles prior to attempting these procedures. The prognosis following surgery and potential complications should be discussed with the client. Audience: This review article aims to assist in decision-making and to provide detailed guidance for primary care clinicians considering referral of cats for corneal surgery. The review outlines common feline corneal diseases and associated surgical therapies performed by veterinary ophthalmologists, highlighting appropriate instrumentation and case selection. Some surgeries are explained in depth for ophthalmologists and residents in training. Equipment: Although some procedures may be performed with common surgical equipment and supplies, most require specialized ophthalmic instrumentation and expertise, which entails significant microsurgical training and practice, as well as financial investment. Most of the procedures require an operating microscope for the best surgical outcomes; however, surgical loupes may be sufficient in some cases. Evidence base: This review article compiles information from many published references on feline corneal diseases and surgeries, complemented by the experience of the authors.
Trans-radial percutaneous intervention for thrombosed hemodialysis access: A single-center experience
Authors: Rao Sudhakar M , Jayaram Ashwal Adamane , VB Mohan , UK Abdul Razak , Rangaswamy Dharshan , Samath Jyothi 
Published: November 2021

Background: Traditionally, percutaneous transluminal angioplasty (PTA) is a first-line approach for stenosed dialysis accesses and has been performed through the non-thrombosed vein segment. For thrombosed accesses, thrombectomy (whether open or percutaneous) is a standard approach. The primary objective of our study is to determine the clinical and technical outcomes of the trans-radial approach of PTA among thrombosed dialysis accesses, in terms of safety and feasibility, technical and clinical aspects and factors influencing them, as well as assisted primary patency, secondary patency at 6 and 12 months. Methods: This is a single-center retrospective study that included 150 patients over 3 years. About 123 patients underwent successful percutaneous balloon angioplasty through the radial access. Results: We report an overall technical and clinical success rate of 82%, assisted primary patency rate of about 90.25% at 3 months, 82.93% at 6 months, 73.18% at 1 year, and secondary patency rate of 94% at 1 year. Twenty-seven patients were referred for surgical revisions/creation of a new fistula for reasons like inability to pass wire (6 patients), unfavorable anatomical variations like aneurysms at the proximal segments (5 patients), inability to cross the fistula (5 patients), and persistent fistula dysfunction with no flow after initial balloon dilatation (11 patients). Three patients had hematoma at the radial access site (2.5%) while two patients had the AV fistula segment rupture and were successfully treated conservatively. Conclusion: We conclude that PTA through the trans-radial approach to completely thrombosed hemodialysis accesses is a good alternative to transvenous access and has a very good assisted primary patency and secondary patency at 1 year without major complications.
Contemporary practice patterns of tyrosine kinase inhibitor use among older patients with chronic myeloid leukemia in the United States
Authors: Shallis Rory M. , Wang Rong , Bewersdorf Jan P. , Zeidan Amer M. , Davidoff Amy J. , Huntington Scott F. , Podoltsev Nikolai A. , Ma Xiaomei 
Published: November 2021

Introduction: The choice of BCR-ABL1 tyrosine kinase inhibitors (TKI) for the first line of therapy (LOT) for chronic-phase chronic myeloid leukemia (CML) is tailored to disease risk and patient characteristics like comorbidities, which become more prevalent with age. However, contemporary evaluations of frontline TKI choice and the factors associated with TKI switching in this specific patient population are lacking. Methods: We sought to describe TKI use in older patients (age: 66–99 years) with CML in the United States. Using the Surveillance, Epidemiology, and End Results–Medicare-linked database, we identified 810 older (median age: 75 years, interquartile range: 70–80 years) patients diagnosed during 2007–2015. Results: Imatinib was the most common frontline TKI (63.1%) throughout the study period, but its utilization as such decreased from 76% in 2010 to 47% in 2015. Most patients (65.3%) used only one TKI, but 12.5% of the 281 patients who switched from frontline TKI received ⩾4 LOT. Among the 167 patients switching from frontline imatinib, 18.6% eventually returned to imatinib with nearly all as the third LOT, supporting its favorable safety profile and indicating that the initial switch from imatinib might have been premature. Older patients within our cohort, white patients and those with greater comorbidity were less likely to switch from frontline TKI. Diagnosis year, geographic region, and surrogates for socioeconomic status and healthcare access had no impact on TKI switching. Conclusion: As expected, our findings highlight the frequent use of imatinib as the treatment option for older CML patients despite the availability of second-generation TKIs.
The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study
Authors: Czubilińska-Łada Justyna , Gliwińska Aleksandra , Świȩtochowska Elżbieta , Nowak-Borzȩcka Lucyna , Sadownik Beata , Behrendt Jakub , Szczepańska Maria 
Published: November 2021

Introduction: Gestational hypertension is one of the most common complications of pregnancy and childbirth worldwide and may be associated with metabolic disorders. Adiponectin is an adipocyte-specific plasma protein with insulin-sensitizing, vascular-protective, anti-inflammatory properties, and its role in metabolic disorders in prenatal and postnatal development in neonates remains unclear. The primary purpose of this study was to determine whether gestational hypertension is a condition lowering cord blood adiponectin level. Next, we have evaluated whether cord blood adiponectin level correlates with selected anthropometric parameters in neonates. Material and methods: The case–control study included 89 newborns divided into two groups: 30 neonates in the study group whose mothers were diagnosed with gestational hypertension and 59 healthy neonates born from normotensive pregnancies. Adiponectin determinations were performed in both groups, and neonatal anthropometric measurements and perinatal data were collected. Results: There was no statistically significant difference ( p = 0.27) between adiponectin concentration in cord blood of newborns from the study group [median (Q1–Q3) 9.86 μg/ml (8.16–13.26 μg/ml)] compared with the control group [median (Q1–Q3) 10.65 μg/ml (8.69–14.29 μg/ml)]. No statistically significant correlations were observed between adiponectin level and gestational age, body weight, body length, and chest circumference. A significant correlation was observed between adiponectin level and head circumference among newborns in the control group and among the entire population of newborns included in the study. Conclusion: No significant influence of gestational hypertension on cord blood adiponectin levels or their correlation with neonatal anthropometric measurements was observed.