bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal liver hematopoiesis: from development to delivery
Authors: Lewis Kyle , Yoshimoto Momoko , Takebe Takanori 
Published: February 2021

AbstractClinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for many hematological diseases; however, therapeutic applications are hampered by donor availability. In vivo, HSC exist in a specified microenvironment called the niche. While most studies of the niche focus on those residing in the bone marrow (BM), a better understanding of the fetal liver niche during development is vital to design human pluripotent stem cell (PSC) culture and may provide valuable insights with regard to expanding HSCs ex vivo for transplantation. This review will discuss the importance of the fetal liver niche in HSC expansion, a feat that occurs during development and has great clinical potential. We will also discuss emerging approaches to generate expandable HSC in cell culture that attain more complexity in the form of cells or organoid models in combination with engineering and systems biology approaches. Overall, delivering HSC by charting developmental principles will help in the understanding of the molecular and biological interactions between HSCs and fetal liver cells for their controlled maturation and expansion.
Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort
Authors: Demiselle Julien , Duval Guillaume , Hamel Jean-François , Renault Anne , Bodet-Contentin Laetitia , Martin-Lefèvre Laurent , Vivier Dominique , Villers Daniel , Lefèvre Montaine , Robert René , Markowicz Philippe , Lavoué Sylvain , Courte Anne , Lebas Eddy , Chevalier Stéphanie , Annweiler Cédric , Lerolle Nicolas 
Published: February 2021

Abstract
Background
Improving outcomes of older patients admitted into intensive care units (ICU) is a raising concern. This study aimed at determining which geriatric and ICU parameters were associated with in-hospital and long-term mortality in this population.

Methods
We conducted a prospective multicentric observational cohort study, including patients aged 75 years and older requiring mechanical ventilation, admitted between September 2012 and December 2013 into ICU of 13 French hospitals. Comprehensive geriatric assessment at ICU admission and ICU usual parameters were registered in a standardized manner. Survival was recorded and comprehensive geriatric assessment was updated after 1 year during a dedicated home visit.

Results
501 patients were analyzed. 108 patients (21.6%) died during the hospital stay. One-year survival rate was 53.8% (IC 95% [49.2%; 58.2%]). Factors associated with increased in-hospital mortality were higher acute illness severity score, resuscitated cardiac arrest as primary ICU diagnosis, perception of anxiety and low quality of life by the proxy, and living in a chronic care facility before ICU admission. Among patients alive at hospital discharge, factors associated with increased 1-year mortality in multivariate analysis were longer duration of mechanical ventilation, all primary ICU diagnoses other than septic shock, a Katz-activities of daily living (ADL) score below 5 and living in a chronic care facility before ICU admission. Among the 163 survivors at 1 year who received a second comprehensive geriatric assessment, the ADL score (functional abilities) showed a significant but moderate decline over time, whereas the Mini-Zarit score (family burden) improved. No significant change in patients’ place of life was observed after 1 year, and quality of life was reported as happy-to-very-happy in 88% of survivors.

Conclusions
The mortality rate remains high among older ICU patients requiring mechanical ventilation. Factors associated with short- and long-term mortality combined geriatric and ICU criteria, which should be jointly evaluated in routine care.
Clinical trial registration NCT01679171
An analytics model for TelecoVAS customers’ basket clustering using ensemble learning approach
Authors: Vahidi Farashah Mohammadsadegh , Etebarian Akbar , Azmi Reza , Ebrahimzadeh Dastjerdi Reza 
Published: February 2021

AbstractValue-Added Services at a Mobile Telecommunication company provide customers with a variety of services. Value-added services generate significant revenue annually for telecommunication companies. Providing solutions that can provide customers of a telecommunication company with relevant and engaging services has become a major challenge in this field. Numerous methods have been proposed so far to analyze customer basket and provide related services. Although these methods have many applications, they still face difficulties in improving the accuracy of bids. This paper combines the X-Means algorithm, the ensemble learning system, and the N-List structure to analyze the customer portfolio of a mobile telecommunication company and provide value-added services. The X-Means algorithm is used to determine the optimal number of clusters and clustering of customers in a mobile telecommunication company. The ensemble learning algorithm is also used to assign categories to new Elder customers, and finally to the N-List structure for customer basket analysis. By simulating the proposed method and comparing it with other methods including KNN, SVM, and deep neural networks, the accuracy improved to about 7%.
A potential subsurface cavity in the continuous ejecta deposits of the Ziwei crater discovered by the Chang’E-3 mission
Authors: Ding Chunyu , Xiao Zhiyong , Su Yan 
Published: February 2021

AbstractIn the radargram obtained by the high-frequency lunar penetrating radar onboard the Chang’E-3 mission, we notice a potential subsurface cavity that has a smaller permittivity compared to the surrounding materials. The two-way travel time between the top and bottom boundaries of the potential cavity is ~ 21 ns, and the entire zone is located within the continuous ejecta deposits of the Ziwei crater, which generally have similar physical properties to typical lunar regolith. We carried out numerical simulations for electromagnetic wave propagation to investigate the nature of this low-permittivity zone. Assuming different shapes for this zone, a comprehensive comparison between our model results and the observed radargram suggests that the roof of this zone is convex and slightly inclined to the south. Modeling subsurface materials with different relative permittivities suggests that the low-permittivity zone is most likely formed due to a subsurface cavity. The maximum vertical dimension of this potential cavity is ~ 3.1 m. While the continuous ejecta deposits of Ziwei crater are largely composed of pre-impact regolith, competent mare basalts were also excavated, which is evident by the abundant meter-scale boulders on the wall and rim of Ziwei crater. We infer that the subsurface cavity is supported by excavated large boulders, which were stacked during the energetic emplacement of the continuous ejecta deposits. However, the exact geometry of this cavity (e.g., the width) cannot be constrained using the single two-dimensional radar profile. This discovery indicates that large voids formed during the emplacement of impact ejecta should be abundant on the Moon, which contributes to the high bulk porosity of the lunar shallow crust, as discovered by the GRAIL mission. Our results further suggest that ground penetrating radar is capable of detecting and deciphering subsurface cavities such as lava tubes, which can be applied in future lunar and deep space explorations.
Construct validity and psychosocial correlates of the Italian version of the 21-item Medical Interview Satisfaction Scale in primary care
Authors: Balestrieri Matteo , de Girolamo Giovanni , Rucci Paola 
Published: February 2021

Background
Satisfaction with the medical interview has been rarely explored in primary care outside the UK, despite evidence suggesting that a trustful doctor–patient relationship is a key ingredient to facilitate treatment adherence and relief from illness-related distress.

Aims
The aims of this study are to analyse the construct validity of the Italian version of the Medical Interview Satisfaction Scale (MISS-21) and its correlations with two outcome measures, the Inventory of Depressive Symptomatology – Self-Report and World Health Organization Quality Of Life Brief Version, in patients with mild-to-moderate depression, recruited in primary care practices.

Method
The factor structure underlying the MISS-21 was investigated with principal component analysis, and the internal consistency of the factors was evaluated with Cronbach's alpha. Network analysis was used to investigate the interrelationships among items. The importance of individual items in the network structure was determined with centrality analyses. Correlations of MISS-21 scores with changes in depression and quality of life were analysed with Spearman's correlation coefficient.

Results
The MISS-21 proved to have a robust four-dimensional factor structure. Cronbach's alpha for the factors ranged from 0.77 to 0.93, suggesting good to excellent internal consistency. The four factors identified were positively correlated with improvement in depressive symptoms and three quality-of-life domains.

Conclusions
The MISS-21 has sound psychometric properties, and comprises four factors related to clinical outcomes, which makes it suitable for clinical and research applications. The central items in the network should be considered as possible targets for quality improvement interventions in primary care.
EPA guidance on assessment of negative symptoms in schizophrenia
Authors: Galderisi S. , Mucci A. , Dollfus S. , Nordentoft M. , Falkai P. , Kaiser S. , Giordano G. M. , Vandevelde A. , Nielsen M. Ø. , Glenthøj L. B. , Sabé M. , Pezzella P. , Bitter I. , Gaebel W. 
Published: February 2021

Abstract

Background
During the last decades, a renewed interest for negative symptoms (NS) was brought about by the increased awareness that they interfere severely with real-life functioning, particularly when they are primary and persistent.

Methods
In this guidance paper, we provide a systematic review of the evidence and elaborate several recommendations for the conceptualization and assessment of NS in clinical trials and practice.

Results
Expert consensus and systematic reviews have provided guidance for the optimal assessment of primary and persistent negative symptoms; second-generation rating scales, which provide a better assessment of the experiential domains, are available; however, NS are still poorly assessed both in research and clinical settings.
This European Psychiatric Association (EPA) guidance recommends the use of persistent negative symptoms (PNS) construct in the context of clinical trials and highlights the need for further efforts to make the definition of PNS consistent across studies in order to exclude as much as possible secondary negative symptoms. We also encourage clinicians to use second-generation scales, at least to complement first-generation ones.
The EPA guidance further recommends the evidence-based exclusion of several items included in first-generation scales from any NS summary or factor score to improve NS measurement in research and clinical settings. Self-rated instruments are suggested to further complement observer-rated scales in NS assessment.
Several recommendations are provided for the identification of secondary negative symptoms in clinical settings.

Conclusions
The dissemination of this guidance paper may promote the development of national guidelines on negative symptom assessment and ultimately improve the care of people with schizophrenia.
Eprenetapopt Plus Azacitidine in TP53-Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia: A Phase II Study by the Groupe Francophone des Myélodysplasies (GFM)
Authors: Cluzeau Thomas , Sebert Marie , Rahmé Ramy , Cuzzubbo Stefania , Lehmann-Che Jacqueline , Madelaine Isabelle , Peterlin Pierre , Bève Blandine , Attalah Habiba , Chermat Fatiha , Miekoutima Elsa , Rauzy Odile Beyne , Recher Christian , Stamatoullas Aspasia , Willems Lise , Raffoux Emmanuel , Berthon Céline , Quesnel Bruno , Loschi Michael , Carpentier Antoine F. , Sallman David A. , Komrokji Rami , Walter-Petrich Anouk , Chevret Sylvie , Ades Lionel , Fenaux Pierre 
Published: February 2021

PURPOSE TP53-mutated ( TP53m) myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) have very poor outcome irrespective of the treatment received, including 40% responses (20% complete remission [CR]) with azacitidine (AZA) alone, short response duration, and a median overall survival (OS) of approximately 6 months. Eprenetapopt (APR-246), a novel first-in-class drug, leads to p53 protein reconformation and reactivates its proapoptotic and cell-cycle arrest functions. PATIENTS AND METHODS This phase II study assessed the safety and efficacy of eprenetapopt in combination with AZA in untreated high or very high International Prognostic Scoring System-R TP53m MDS and AML patients. RESULTS Fifty-two TP53m patients (34 MDS, 18 AML [including seven with more than 30% blasts]) were enrolled. In MDS, we observed an overall response rate (ORR) of 62%, including 47% CR, with a median duration of response at 10.4 months. In AML, the ORR was 33% including 17% CR (27% and 0% CR in AML with less than and more than 30% marrow blasts, respectively). Seventy-three percent of responders achieved TP53 next-generation sequencing negativity (ie, variant allele frequency < 5%). The main treatment-related adverse events were febrile neutropenia (36%) and neurologic adverse events (40%), the latter correlating with a lower glomerular filtration rate at treatment onset ( P < .01) and higher age ( P = .05), and resolving with temporary drug interruption without recurrence after adequate eprenetapopt dose reduction. With a median follow-up of 9.7 months, median OS was 12.1 months in MDS, and 13.9 and 3.0 months in AML with less than and more than 30% marrow blasts, respectively. CONCLUSION In this very high-risk population of TP53m MDS and AML patients, eprenetapopt combined with AZA was safe and showed potentially higher ORR and CR rate, and longer OS than reported with AZA alone.
Erythrocytosis in a Large Cohort of Trans Men Using Testosterone: A Long-Term Follow-Up Study on Prevalence, Determinants, and Exposure Years
Authors: Madsen Milou Cecilia , van Dijk Dennis , Wiepjes Chantal Maria , Conemans Elfi Barbara , Thijs Abel , den Heijer Martin 
Published: February 2021

Abstract

Context
Erythrocytosis is a known side effect of testosterone therapy that can increase the risk of thromboembolic events.

Objectives
To study the prevalence and determinants in the development of erythrocytosis in trans men using testosterone.

Methods
A 20-year follow-up study in adult trans men who started testosterone therapy and had monitoring of hematocrit at our center (n = 1073).

Results
Erythrocytosis occurred in 11% (hematocrit &gt; 0.50 L/L), 3.7% (hematocrit &gt; 0.52 L/L), and 0.5% (hematocrit &gt; 0.54 L/L) of trans men. Tobacco use (odds ratio [OR] 2.2; 95% CI, 1.6-3.3), long-acting undecanoate injections (OR 2.9; 95% CI, 1.7-5.0), age at initiation of hormone therapy (OR 5.9; 95% CI, 2.8-12.3), body mass index (BMI) (OR 3.7; 95% CI, 2.2-6.2), and pulmonary conditions associated with erythrocytosis and polycythemia vera (OR 2.5; 95% CI, 1.4-4.4) were associated with hematocrit &gt; 0.50 L/L. In the first year of testosterone therapy hematocrit increased most: 0.39 L/L at baseline to 0.45 L/L after 1 year. Although there was only a slight continuation of this increase in the following 20 years, the probability of developing erythrocytosis still increased (10% after 1 year, 38% after 10 years).

Conclusion
Erythrocytosis occurs in trans men using testosterone. The largest increase in hematocrit was seen in the first year, but also after the first years a substantial number of people present with hematocrit &gt; 0.50 L/L. A reasonable first step in the care for trans men with erythrocytosis while on testosterone is to advise them to quit smoking, to switch to a transdermal administration route, and if BMI is high, to lose weight.
Laocoön’s Scream; or, Lessing Redux
Authors: Gyenge Andrea 
Published: February 2021

AbstractThis article returns to the figure of the mouth in Gotthold Ephraim Lessing’s Laocoön: An Essay on the Limits of Painting and Poetry. While many scholars treat Lessing’s attention to the statue’s mouth as a sign of his contempt for the body, the article argues that Lessing’s interest in orality is a test of the limits of the eighteenth century’s neoclassicism. The article concludes that Lessing is thus not a representative of conservative aesthetics but a proto-Freudian thinker who inadvertently challenged the foundations of his own aesthetic project.
What IsLeitkultur?
Authors: Cattien Jana 
Published: February 2021

AbstractThis article interrogates the discursive regimes that underpin Leitkultur (guiding culture) discourse in contemporary Germany and argues that Leitkultur conjures Germany’s imagined “freedom from history” from within Enlightenment temporalities of liberal freedom. This requires that liberal Germany mark its limits in certain moments of German history—namely, National Socialism—while disavowing its role in the constitution of German colonialism. The return to the Enlightenment implied in hegemonic formulations of Leitkultur restores Germany’s freedom from an ugly past; this imagined return can carry the promise of a “diverse” and “inclusive” Germany only insofar as Germany’s colonial heritage is suppressed. The article aims to expose how Germany’s colonial legacy underpins dominant Leitkultur discourse while it is nevertheless hidden from it.
Combined heterogeneity in cell size and deformability promotes cancer invasiveness
Authors: Asadullah  , Kumar Sandeep , Saxena Neha , Sarkar Madhurima , Barai Amlan , Sen Shamik 
Published: February 2021

ABSTRACT
Phenotypic heterogeneity is increasingly acknowledged to confer several advantages to cancer progression and drug resistance. Here, we probe the collective importance of heterogeneity in cell size and deformability in breast cancer invasion. A computational model of invasion of a heterogeneous cell aggregate predicts that combined heterogeneity in cell size and deformability enhances invasiveness of the whole population, with maximum invasiveness at intermediate cell-cell adhesion. We then show that small cells of varying deformability, a subpopulation predicted to be enriched at the invasive front, exhibit considerable overlap with the biophysical properties of cancer stem cells (CSCs). In MDA-MB-231 cells, these include CD44hi CD24− mesenchymal CSCs, which are small and soft, and CD44hi CD24+ hybrid CSCs, which exhibit a wide range of size and deformability. We validate our predictions by tracking the pattern of cell invasion from spheroids implanted in three-dimensional collagen gels, wherein we show temporal enrichment of CD44hi cells at the invasive front. Collectively, our results illustrate the advantages imparted by biophysical heterogeneity in enhancing cancer invasiveness.
This article has an associated First Person interview with the first author of the paper.
Why Join a Team?
Authors: Cooper David J. , Saral Krista , Villeval Marie Claire 
Published: February 2021

We present experiments exploring why high ability workers join teams with less able coworkers when there are no short-term financial benefits. We distinguish between two explanations: prosocial preferences and expected long-term financial gains from teaching future teammates. Participants perform a real-effort task and decide whether to work independently or join a two-person team. Treatments vary the payment scheme (piece rate or revenue sharing), whether teammates can communicate, and the role of teaching. High ability workers are more willing to join teams in the absence of revenue sharing and less willing to join teams when they cannot communicate. When communication is possible, the choice of high ability workers to join teams is driven by expected future financial gains from teaching rather than some variety of prosocial preferences. This result has important implications for the role of adverse selection in determining the productivity of teams. This paper was accepted by Yan Chen, decision analysis.
Supply Chains and Antitrust Governance
Authors: Jain Nitish , Hasija Sameer , Netessine Serguei 
Published: February 2021

Antitrust regulations are meant to promote fair competition in the market, but balancing administrative and legal costs with enforcement can be difficult when multilayered supply chains are involved. The canonical example of this challenge is the landmark Illinois Brick ruling, which limits antitrust damages to only the direct purchasers of a product; for instance, consumers can file antitrust claims against colluding retailers but not against colluding manufacturers—only retailers can file claims against manufacturers. This controversial ruling was meant to reduce legal costs, but it can clearly lead to missed enforcement opportunities. In this paper, we demonstrate how the Illinois Brick ruling interacts with contracts adopted in the supply chain, and we show that otherwise equivalent supply chain arrangements can have markedly different effects. In particular, we find that wholesale price, minimum order quantity, revenue sharing, and quantity discount contracts lead retailers to take legal action against manufacturers in the event of collusive behavior. However, the wholesale price plus fixed fee contract structure (also known as a two-part tariff or slotting fee contract) facilitates collusion among the manufacturers with retailers compensated by the fixed fee and not filing the antitrust litigation. We further demonstrate that collusion is more likely under high demand uncertainty and high competition at the retail level but is less likely under high competition at the manufacturer level. Our paper helps public enforcers identify market conditions conducive to antitrust violations. This paper was accepted by Vishal Gaur, operations management.
REPRESENTASI KELUGASAN BERANDA LAMAN WWW.COVID19.GO.ID: TINJAUAN ANALISIS WACANA KRITIS
Authors: Suswandi Irwan 
Published: February 2021

The digital era has encourages information providers to innovate by utilizing the internet to convey information quickly. No exception for the government in a way to provide information and news related to Covid-19 which has become a global pandemic. Using a website as a source of information can give quick access for people to obtain actual and valid information relating to Covid-19. Through www.covid19.go.id, the government provides a facility for people to be able to access all information about Covid-19 matters. In this research, the researcher will analyze how government gives simplicity in providing information related to Covid-19, which is represented on the www.covid19.go.id homepage. The researcher used CDA (critical discourse analysis) theory from Fairclough to analyze the text found on the www.covid19.go.id homepage. Then, the results of critical discourse analysis were linked with the reputation theory of Charles J. Fombrun. The analysis produced information in the form of language units of www.covid19.go.id homepage which contains a simplicity matter in the delivery of information. From this analysis, the researcher can conclude that the simplicity in www.covid19.go.id homepage was represented through the website components, content, and propositions contained in the homepage. The simplicity matter also found in the use of modes, those were descriptive, persuasive, and interrogative mode.