bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emasculating healers. Medical castration practices in Greco-Roman antiquity*
Authors: König Jacqueline G. M. 
Published: July 2021

AbstractIn the course of the human past the elimination of the testicles of boys and men – what we call castration – has taken place for a variety of reasons. Many times it was meant to deliberately hurt people. It is and was also performed, though, as a therapeutic measure by well-meaning physicians. Studying the motivations of medical practitioners involved in castration practices provides insight into the deontology and cultural context of these healers. This article explores the healing activities of the physicians of the ancient Greek and Roman worlds in this special field of surgery. In the extant literary sources we find medical indications for castration which are quite obvious to a modern eye, but also more mysterious and unexpected occasions which need to be explained from the historical context.
Crystal structure of poly[bis[μ
3-1,3,5-tris[(1H-imidazol-1-yl)methyl]benzene-κ
3
N:N′:N″]nickel(II)] hexafluorosilicate, C36H36N12NiSiF6
Authors: Xu Xi‐Ting , Dong Tong‐Min , Song Wei , Zhong Kai‐Long 
Published: July 2021

Abstract
C36H36N12NiSiF6, trigonal,

P

3
‾

$P&#x203e;{3}$

(no. 147), a = 9.5965(3) Å, c = 11.8821(8) Å, V = 947.65(9) Å3, Z = 1, R

gt
(F) = 0.0437, wR

ref
(F
2) = 0.1076, T = 223 K.
Histological regression of gastrointestinal peritoneal metastases after systemic chemotherapy
Authors: Toussaint Laura , Teixeira Farinha Hugo , Barras Jean-Luc , Demartines Nicolas , Sempoux Christine , Hübner Martin 
Published: July 2021

Abstract

Objectives
Peritoneal metastases (PM) are relatively resistant to systemic chemotherapy, and data on histological response to therapy is rare. The aim of this study was to quantify the treatment response of PM after systemic chemotherapy.

Methods
Retrospective monocentric cohort study of 47 consecutive patients with PM from gastrointestinal origin undergoing surgery (cytoreduction: CRS + Hyperthermic IntraPEritoneal Chemotherapy [HIPEC] or Pressurized IntraPeritoneal Aerosol Chemotherapy [PIPAC]) after prior systemic chemotherapy from 1.2015 to 3.2019. Tumor response was assessed using the 4-scale Peritoneal Regression Grading System (PRGS) (4: vital tumor to 1: complete response).

Results
Patients had a median of 2 (range: 1–7) lines and 10 (3–39) cycles of prior systemic chemotherapy. A median of four biopsies (range: 3–8) was taken with a total of 196 analyzed specimens. Twenty-four biopsies (12%) showed no histological regression (PRGS4), while PRGS 3, two and one were diagnosed in 37 (19%), 39 (20%), and 69 (49%) specimens, respectively. A significant heterogeneity was found between peritoneal biopsies in 51% patients. PRGS correlated strongly with peritoneal spread (PCI, p<0.0001), and was improved in patients with more than nine cycles of systemic chemotherapy (p=0.04). Median survival was higher in patients with PRGS < 1.8 (Quartiles one and 2) than higher (Q3 and Q4), but the difference did not reach significance in this small cohort.

Conclusions
PRGS is an objective too to describe histological response of PM of GI origin after systemic chemotherapy. This response differs significantly between patients, allowing to distinguish between chemosensitive and chemoresistant tumors.
Cremated animal remains and shattered pottery. Rare ritual deposits from the Middle to Late Bronze Age at Aalst – Siesegemkouter (Belgium)
Authors: Verbrugge Arne , Groot Maaike , Deforce Koen , Mulder Guy De , Meer Wouter Van der , Reniere Sibrecht , Cherretté Bart , Boudin Mathieu , Ervynck Anton 
Published: July 2021

Abstract
Archaeological research at Aalst – Siesegemkouter revealed several pits within a Middle to Late Bronze Age settlement. Most of them hardly contained any artefacts, but one exception showed a structured stratigraphy with an abundance of finds, including a large amount of shattered pottery, charcoal and calcined animal bone. The study of this assemblage, and comparison with two other pits showing similarities, provides strong indications of a closing deposit or another type of ‘site maintenance practice’. In the Low Countries, comparable contexts generally date from the Iron Age, suggesting that the finds from Aalst – Siesegemkouter represent early forerunners of this ritual practice. On top of this early date, the large volume of cremated animal bone represents an almost unique characteristic for which, until now, parallels from the Metal Ages have hardly been found, even on a Northwestern European scale. In general, the role played by organic remains in ritual contexts from these periods and regions is poorly understood, often due to bad preservation conditions or the lack of a multidisciplinary approach.
Lean mass, magnesium, faecal calprotectin and glucocorticoid exposure as risk factors for low bone mineral density in inflammatory bowel disease patients
Authors: Soare Iulia , Sirbu Anca , Diculescu Mihai Mircea , Mateescu Bogdan Radu , Tieranu Cristian , Martin Sorina , Barbu Carmen Gabriela , Ionescu Mirela , Fica Simona 
Published: July 2021

Background and aim
Low bone mineral density (BMD) is a common complication in patients with inflammatory bowel disease (IBD). However, debates are ongoing with regard to the other involved factors, especially in younger patients. This study aimed to evaluate the parameters that contribute to decreased BMD, focusing on premenopausal women and men aged <50 years.

Methods
This study included 81 patients with IBD and 81 age-, sex- and BMI-matched controls. Blood tests were conducted on IBD patients, and a dual-energy X-ray absorptiometry (DXA) scan was performed on both groups.

Results
Low BMD and fragility fracture were found to be more prevalent in IBD patients than in healthy subjects (49.3% vs 23.4%, P = 0.001 and 9.8% vs 1.2%, P = 0.01, respectively). Patients with low BMD were older, with a longer disease duration, higher faecal calprotectin (FC) levels and lower magnesium and lean mass (appreciated as appendicular skeletal muscle index (ASMI)). Multiple regression analysis revealed that ASMI, age and use of glucocorticoids were the independent parameters for decreased BMD. Although 91.3% of the patients had a 25-hydroxy vitamin D level of <30 ng/mL, it was not a statistically significant factor for decreased BMD.

Conclusion
In our study, the levels of vitamin D did not seem to have an important impact on BMD. Conversely, FC, magnesium and lean mass are important factors, suggesting that good control of disease, adequate magnesium intake and increased lean mass can have a good impact on bone metabolism in patients with IBD.
MOTIVACIÓN INTRÍNSECA, INTELIGENCIA EMOCIONAL Y AUTORREGULACIÓN DEL APRENDIZAJE: UN ANÁLISIS MULTINIVEL
Authors: Rodríguez-González P. , Cecchini J.A. , Méndez-Giménez A. , Sánchez-Martínez B. 
Published: July 2021

La finalidad del estudio es modelar, por primera vez, las relaciones entre la motivación intrínseca, la inteligencia emocional y la autorregulación del aprendizaje en las clases de Educación Física (EF). La muestra estuvo formada por 480 estudiantes (248 varones y 232 mujeres) de cuarto curso de Educación Primaria (M = 9,29, DT = 0,52) procedentes de un total de 23 clases de EF. El análisis multinivel, tomando la motivación intrínseca como variable dependiente, reveló un efecto estadísticamente significativo para el profesor (colegio), la planificación, la autocomprobación, el esfuerzo, la regulación, el control emocional y el reconocimiento emocional. La reducción en el coeficiente de correlación intraclase, del modelo nulo al modelo final, fue aproximadamente del 67%. Promover el desarrollo de inteligencia emocional y la mejora de la autorregulación en las clases de EF podría incrementar la motivación intrínseca del alumnado por la materia.
Beneficios de la lactancia materna
Authors: Meza-Salcedo Rocío , Pérez-Valverde Alan 
Published: July 2021

Sr. Editor.
Debido a la pandemia por COVID-19 se puso en duda la importancia de la lactancia materna, por la probabilidad de contagio al bebé o recién nacido; por ello plantearemos la importancia de los beneficios, priorizando al ser humano futuro y tratando de encontrar un equilibrio entre salud bucal, salud general y riesgos generales, siempre con un enfoque multidisciplinario y basada en evidencias
Ciclo de conversión del efectivo y su incidencia en la liquidez de una empresa industrial
Authors: Diaz Cuenca Patrick Ademir , Ramón Martínez Jesabel Jesús 
Published: July 2021

Objetivo: Establecer la incidencia del ciclo de conversión del efectivo en la liquidez de la empresa industrial Damar G&L S.A.C de Lima, durante los periodos 2016 al 2019. Método: El estudio presentó un enfoque cuantitativo con un alcance correlacional de corte transversal, utilizando un diseño no experimental. El método aplicado para la recolección de los datos fue el análisis documental; como población de estudio se utilizó datos de los registros contables de cuentas por cobrar, inventarios y cuentas por pagar de la empresa, estructurados en 48 estados financieros mensualizados. Resultados: Los resultados evidencian una relación mínima no significativa entre el ciclo de conversión del efectivo y la liquidez (Rho = .075, p = .614) correspondiente a los periodos en estudio; asimismo, los indicadores de la variable independiente, periodo de rotación de cuentas por cobrar, periodo de rotación de inventarios y periodo de rotación de cuentas por pagar, muestran una relación débil (Rho = .201, -.267, .086) en la prueba ácida, con un nivel de significancia mayor al 5%. Conclusión: Se concluye que durante el periodo comprendido 2016 al 2019 de la empresa en estudio, el ciclo de conversión del efectivo no incide directamente en la liquidez.
Presencia de haplotipos reproductivos y su efecto en una población de vacunos lecheros en la costa central del Perú
Authors: Calderón Velásquez Jorge Pedro , Gutiérrez Reynoso Gustavo Augusto , Garay Livia Gladys Luz 
Published: July 2021

Se utilizaron 6350 registros de reproducción de un rebaño lechero entre 2000 hasta el primer semestre de 2016, con base a los índices reproductivos del rebaño, considerando el número de servicios por preñez, días vacíos, tasa de preñez y ocurrencia de abortos. Se genotiparon 58 vacas Holstein seleccionadas al azar para determinar la presencia de haplotipos reproductivos (HH) que afectan el comportamiento reproductivo de las vacas produciendo abortos. Se determinó que el 5.2% de las vacas eran portadoras para HH1, 5.2% para HH3 y 3.4% para HH5, no encontrándose animales portadores para los haplotipos HH2 y HH4. El 75% de las vacas portadoras (6/8) presentaron abortos no asociados al haplotipo, a excepción de un evento cuyo reproductor fue portador para el HH3. Asimismo, el 54% de las vacas no portadoras presentaron eventos de aborto (27/50), no estableciéndose un efecto directo del haplotipo sobre la ocurrencia de abortos. El número de servicios por preñez asociado con la tasa de concepción genómica (CCR) determinó una correlación de 8.3% (p>0.05) y un coeficiente de regresión de -0.07115 servicios (p>0.05). De los cinco grupos genéticos de padres encontrados en el rebaño, cuatro grupos genéticos tienen presencia a través de la progenie de machos que presentaron los haplotipos reproductivos.
Image segmentation and analysis for densification mapping of nanoporous gold after nanoindentation
Authors: Richert Claudia , Wu Yijuan , Hablitzel Murilo , Lilleodden Erica T. , Huber Norbert 
Published: July 2021

AbstractSegmentation of scanning electron microscopy (SEM) images of focused ion beam (FIB) cross-sections through indented regions in nanoporous gold (np-Au) is carried out. A key challenge for image analysis of open porous materials is the appropriate binarization of the pore and gold ligament regions while excluding material lying below the cross-sectional plane. Here, a manual approach to thresholding is compared to global and local approaches. The global thresholding resulted in excessive deviations from the nominal solid fraction, due to a strong gray-scale gradient caused by the tilt angle during imaging and material shadowing. In contrast, the local thresholding approach delivered local solid fractions that were free of global gradients, and delivered a quality comparable to the manual segmentation. The extracted densification profiles vertically below the indenter as well as parallel to the surface showed an exponential-type decay from the indenter tip towards the nominal value of 1 far from the indenter.
Graphic abstract
VIRAL DELIVERY USING SCAFFOLDS
Authors: Laevskaya A. A. , Kosenchuk V. V. , Yakushov S. I. , Timashev P. S. , Ulasov I. V. 
Published: July 2021

In experimental oncology there are multiple approaches have been developed to target tumor cells. Many of them are based on scaffolds, a 3D models that mimics the structure of tissue in normal and pathophysiological state. It is known that to deliver a viral load to target cells, cells-carriers undergo limited differentiation, and premature aging. Since viral agents require cells to be in specific proliferative state, the delivery of the virus to the target cell is the main goal of the functional framework such as scaffold. Over decade, multiple studies demonstrate the production of scaffolds using matrigel, polyalacinic acid, poly-lactide-co-glycolide, vinyl stilbens, or bioactive polymers. Our review will describe the potential benefits of delivering the viral vector using 3D scaffolds for virus-mediated expression of biologically active substances that prevent angiogenesis, neoplasm proliferation, or, conversely, stimulate wound healing. 3D materials such as hydrogels and scaffolds are among the key innovations in the field of material chemistry. Moreover, viral vectors provide specific delivery of genes to target cells. However, the immunogenicity of a viral capsid consisting of viral proteins hinders the clinical use of such vectors widely. These limitations can be surmounted by using scaffolds. Therefore, our review might interest researchers working in the fields of chemistry, materials science and natural sciences, as well as in the field of bioengineering and medical technologies.
AVALIAÇÃO DA CASCATA DE CUIDADO CONTÍNUO EM INDIVÍDUOS COM HIV/AIDS EM UM CENTRO AMBULATORIAL DE REFERÊNCIA NO NORDESTE DO BRASIL
Authors: Farias Geysa Maria Nogueira , Pinto José Reginaldo , Junior Geraldo Bezerra da Silva , Colares Jeová Keny Baima , Távora Lara Gurgel Fernandes , Lima Danielle Malta 
Published: July 2021

Objetivo: A cascata de cuidado contínuo surgiu como uma estratégia para se transpor a infecção por HIV e se alcançar o objetivo final em cuidados, que seria a supressão viral. Este estudo tem como objetivo descrever a cascata de cuidado contínuo em indivíduos com HIV/AIDS em um Serviço Ambulatorial Especializado. Metodologia: Esse é um estudo de coorte retrospectivo que analisou indivíduos adultos com diagnóstico confirmado de HIV/AIDS que iniciaram seu acompanhamento no Núcleo de Atenção Médica Integrada (NAMI) da Universidade de Fortaleza (UNIFOR), cidade de Fortaleza, estado do Ceará, na região Nordeste do Brasil. Os dados que se seguem foram usados na pesquisa: carga viral CD4+/CD8+ e carga viral do HIV. Os participantes foram classificados em dois grupos: retidos no cuidado em saúde (grupo 1) e não retidos no cuidado em saúde (grupo 2), totalizando uma coorte de 511 participantes. Resultados: A análise univariada entre os grupos demonstrou que havia predominância significativa de pacientes homens com média de idade mais alta no grupo 1 (p = 0,01). Um histórico prévio de dependência química quando da primeira consulta foi mais frequente no grupo 2 (p = 0,001 e p = 0,01 respectivamente). Os pacientes do grupo 1 tinham um histórico mais frequente de infecções sexualmente transmissíveis (IST) (p=0,002) e estavam mais imunossuprimidos quando do diagnóstico (p = 0,002). O uso de terapia antirretroviral (TARV) na primeira consulta foi mais significativo no grupo de pacientes retidos (p<0,001). Conclusões: Este estudo sugere a necessidade de aprimoramento da “cascata de cuidados” através de sua expansão, na medida em que considere riscos comportamentais dinâmicos, o que poderia transpor as barreiras sistêmicas de acesso aos serviços de saúde para as pessoas que vivem com HIV/AIDS.
AnÃ¡lise espacial da mortalidade fetal e carÃªncia social: estudo ecolÃ³gico
Authors: Canuto Indianara Maria de Barros , MacÃªdo Vilma Costa de , Bonfim Cristine Vieira do 
Published: July 2021

Objetivo: Analisar a dinÃ¢mica espacial da mortalidade fetal e sua relaÃ§Ã£o com a carÃªncia social. MÃ©todo: Estudo ecolÃ³gico, cujasÂ unidadesÂ de anÃ¡lise serÃ£o os municÃ­pios de Pernambuco. O cÃ¡lculo das taxas de mortalidade fetal incluirÃ¡ Ã³bitos fetais de residentes em Pernambuco entre 2010 e 2017, registrados no Sistema de InformaÃ§Ãµes sobre Mortalidade. O Ã­ndice de carÃªncia sÃ³cialÂ serÃ¡ elaborado comÂ dados do Censo 2010 do Instituto Brasileiro de Geografia e EstatÃ­stica que apresentem significÃ¢ncia estatÃ­stica com a mortalidade fetal.OÂ calculo doÂ Ã­ndice utilizarÃ¡Â a tÃ©cnica de anÃ¡lise fatorial por componentes principais com rotaÃ§Ã£o ortogonal varimax. Na anÃ¡lise espacialÂ serÃ¡ aplicado o mÃ©todo bayesiano empÃ­rico, e calculados os Ã­ndices de autocorrelaÃ§Ã£o espacial de Moran local e global. Resultados esperados:Â A identificaÃ§Ã£o da relaÃ§Ã£o da carÃªncia social com a dinÃ¢mica espacial da mortalidade fetal, a fim de auxiliar no desenvolvimento de aÃ§Ãµes em saÃºde ao apontar Ã¡reas que necessitam de atenÃ§Ã£o prioritÃ¡ria.
Ser enfermeiro no quotidiano da AtenÃ§Ã£o PrimÃ¡ria Ã saÃºde: o fazer, o aprender e o conviver
Authors: Silva LÃ­via Silveira , Viegas Selma Maria da Fonseca , Menezes CÃ¡ssia 
Published: July 2021

Objetivo: compreender o quotidiano do enfermeiro na AtenÃ§Ã£o PrimÃ¡ria Ã SaÃºde (APS) e suas vivÃªncias como ser, no fazer, aprender e conviver. MÃ©todo: estudo de casos mÃºltiplos holÃ­stico-qualitativo, fundamentado na Sociologia Compreensiva do Quotidiano, com 54 enfermeiros. Resultados: o ser enfermeiro na APS vivencia o protagonismo, a autonomia, a aplicabilidade de conhecimentos e as habilidades profissionais, ao desempenhar o fazer com humanizaÃ§Ã£o, empatia, responsabilidade e Ã©tica. Os enfermeiros vivem, aprendem e convivem com os desafios quotidianos, como elevado nÃºmero de pessoas cadastradas, falta de recursos humanos, elevada demanda espontÃ¢nea e reprimida, atenÃ§Ã£o centrada no adoecimento e necessidade de EducaÃ§Ã£o Permanente. ConsideraÃ§Ãµes finais: o ser, fazer, aprender e conviver dos enfermeiros Ã© pautado por grandes responsabilidades e cobranÃ§as em torno do que Ã© ideal e o que Ã© real no quotidiano da APS. A infraestrutura e a funcionalidade das unidades de APS encontram-se longÃ­nquas da realidade idealizada e desejada.
Representações sociais atribuídas pelo homem ao pré-natal da companheira: estudo descritivo
Authors: Oliveira Sylvia Silva de , Medeiros Anderson Brito de , Temoteo Rayrla Cristina de Abreu , Lopes Thaís Rosental Gabriel , Miranda Francisco Arnoldo Nunes de , Carvalho Jovanka Bittencourt Leite de 
Published: July 2021

OBJETIVO: analisar as Representações Sociais atribuídas pelo homem ao pré-natal da companheira. MÉTODO: estudo descritivo, com aporte teórico na Teoria das Representações Sociais, na perspectiva estrutural. Participarão do estudo homens que vivenciaram o pré-natal e estejam presentes com a sua companheira no período pós-parto. A coleta de dados será efetuada em uma maternidade escola, situada em Natal-RN, Brasil, por meio da utilização de uma entrevista semidirigida. No que concerne à análise dos dados adotar-se-á os pressupostos da Teoria das Representações Sociais, bem como os achados da literatura os quais sejam pertinentes à temática. RESULTADOS ESPERADOS: almeja-se que o estudo propicie a apreensão do quão relevante é a participação do homem, como futuro pai, no contexto das consultas de pré-natal da companheira, além de subsidiar o planejamento de ações de Enfermagem contributivas para a inserção do homem nas consultas de pré-natal.
La correspondencia «familiar» de José Nicolás de Azara con su hermano Eustaquio, obispo de Barcelona (Ms. 3783 de la Biblioteca de Catalunya)
Authors: Gimeno Puyol María Dolores 
Published: July 2021

Entre la abundante correspondencia del diplomático ilustrado José Nicolás de Azara, el Ms. 3783 de la Biblioteca de Catalunya posee 11 cartas que dirigió en 1795-1796 desde Roma a su hermano mayor, Eustaquio quien entonces ocupaba la sede episcopal de Barcelona hasta su fallecimiento en junio de 1797. El conjunto ofrece el interés de mostrar cómo eran las relaciones entre dos hermanos que se habían separado en la edad temprana para seguir sus respectivas carreras en la alta administración y la Iglesia de su tiempo. Presumiblemente, es solo una parte de un epistolario más extenso y sólo contiene las cartas de uno de los corresponsales, pero permite advertir las preocupaciones ilustradas de ambos, los temas de actualidad que trataron así como el tono de confianza y estilo llano, propios del intercambio epistolar familiar o privado. Su edición anotada intenta reconstruir el contexto español y europeo sobre el que se sustenta.PALABRAS CLAVEIlustración. Siglo XVIII. Género epistolar. Cartas familiares. José Nicolás de Azara. Le Ms. 3783 contient 11 lettres du diplomate éclairé José Nicolas de Azara, auteur d’une nombreuse correspondance, qu’il a adressées entre 1795 et 1796 depuis Rome à son frère aîné Eustaquio, qui était alors évêque de Barcelone jusqu’à son décès en juin 1797. L’ensemble présente l’intérêt de montrer les relations entre deux frères qui s’étaient séparés à un âge précoce pour suivre leurs carrières, l’un dans la haute administration et l’autre dans l’Église de son temps. Celle-ci n’est, probablement, qu’une partie d’une correspondance plus large et elle contient seulement les lettres de l’un des correspondants, mais qui permet d’y remarquer les inquiétudes éclairées des deux frères, les sujets d’actualité qu’ils ont traités ainsi que le climat de confiance et le style simple, proles à l’échange épistolaire familial ou privé. Son édition annotée essaie de reconstruire le contexte espagnol et européen dont il se nourrit.MOTS-CLÉLumières. XVIIIè siècle. Genre épistolaire. Lettres familiales. José Nicolás de Azara.
ANISOtime: Traveltime Computation Software for Laterally Homogeneous, Transversely Isotropic, Spherical Media
Authors: Konishi Kensuke , Borgeaud Anselme F. E. , Kawai Kenji , Geller Robert J. 
Published: July 2021

Abstract
Software packages for computing seismic traveltimes and raypaths in an isotropic, spherically symmetric, Earth model are well known and widely used. However, even though the theory for transversely isotropic (TI), spherically symmetric, models has been known since the late 1960s, readily available programs for traveltime calculations are restricted to isotropic models. We have developed a new software package, ANISOtime, for computing seismic traveltimes and raypaths in laterally homogeneous, TI, spherical media. This package calculates traveltime tables for both immediate and subsequent use. ANISOtime has both graphical user interface and command-line interface modes. The package is available for free public download. As it offers cross-platform compatibility through Java 8, it runs on Windows, macOS, Unix, and Linux.