bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐Portal Approach of Arthroscopy for Anterior Ankle Impingement Syndrome: A Propensity Score‐Matched Analysis
Authors: Wang Zeng‐liang , Cui Lei , Li Gui‐shi 
Published: January 2021

ObjectiveTo introduce a 3‐portal approach of arthroscopic for anterior ankle impingement syndrome and to compare this method with 2‐portal arthroscopy.MethodsFrom July 2011 to April 2019, a total of 52 patients (30 females, 22 males) with anterior ankle impingement syndrome underwent surgery with 2‐portal approach (anterior medial and anterior lateral approach; N = 26) and modified 3‐portal approach (anterior medial, anterior lateral, and an accessory anterior median approach; N = 26) of arthroscopic were recruited retrospectively after we performed a propensity score‐matched analysis (PSMA). The mean age at operation time was 44.1 years (range from 22 years to 74 years) and the mean follow‐up duration was more than two years (range from 2 years to 9 years). Clinical outcomes of all patients were evaluated according to the range of motion (ROM, dorsal flex angle), the American Orthopaedic Foot and Ankle Society lesser metatarsophalangeal interphalangeal scale (AOFAS), the visual analogue scale (VAS), and the operation time before and after the surgery.ResultsDuring the follow‐up period, both two groups indicated significant improvement in these function scores. Clinical assessment showed that for the 2‐portal approach of arthroscopic the total average of AOFAS scores were significantly increased from preoperative 59.91 ± 5.281 points to postoperative 76.18 ± 1.471 points (P = 0.02), the VAS scores were significantly decreased from preoperative 7.64 ± 0.924 points to postoperative 4.18 ± 0.982 points (P = 0.04), and the dorsal flex angle was significantly increased from preoperative 12.27° ± 6.467° to postoperative 21.36° ± 3.931° at the last follow‐up (P = 0.035). However, for the 3‐portal approach of arthroscopic the total average of AOFAS scores were significantly increased from preoperative 48.64 ± 9.646 points to postoperative 79.18 ± 6.555 points (P = 0.015), the VAS scores were significantly decreased from preoperative 7.82 ± 0.751 points to postoperative 2.64 ± 1.629 points (P = 0.01), and the dorsal flex angle was significantly increased from preoperative 13.64° ± 7.775° to postoperative 20.45° ± 6.502° at the last follow‐up (P = 0.045). There were no significant differences among the dorsal flex angle, the AOFAS scores, and the VAS scores between the two groups at the last follow‐up (P > 0.05). Although the operation time of the 3‐portal approach of arthroscopic (74.82 ± 18.395 min) was longer than that of the 2‐portal approach of arthroscopic (92.55 ± 27.153 min), the difference was not significant (P > 0.05).ConclusionBoth the 2‐portal and the 3‐portal approach of arthroscopic provides almost the same satisfactory clinical outcomes for anterior ankle impingement syndrome, but we strongly suggest the 3‐portal approach of arthroscopic which can supply greater joint contact area to treat advanced impingement syndrome for a good result.
Clinical characteristics and management of clinically amyopathic juvenile dermatomyositis across four academic centers
Authors: Bradley Flora , Bayer Michelle L. , Co Dominic O. , Chiu Yvonne , Huber Adam M. , Ahmad Regina‐Celeste , Baris Hatice E. , Oberle Edward J. , Kim Susan 
Published: January 2021

AbstractBackground/ObjectivesClinically amyopathic juvenile dermatomyositis (CAJDM) is an uncommon but important subset of patients with juvenile dermatomyositis, characterized by pathognomonic cutaneous findings without clinically evident muscle weakness. With limited data available and lack of standardized management guidelines for CAJDM, we sought to describe common features, including early indicators that may be associated with progression of muscle disease, and review the course and treatment of these patients.MethodsA retrospective chart review of patients with CAJDM was conducted at four North American academic centers between the years 2000 and 2015.ResultsTwenty‐nine patients were included, of whom 21 (72%) were female. After a median follow‐up of 4 years (IQR 1.8‐5.8 years), 5 of the 29 (17%) patients with CAJDM evolved into classic juvenile dermatomyositis. Median time to develop weakness was 12 months (IQR 8‐19 months) after diagnosis. The skin disease of CAJDM patients who did not develop weakness was often found to be recalcitrant with 58% of them requiring multiple systemic therapies to control their cutaneous disease.ConclusionThese results highlight the need for long‐term monitoring for the development of myositis in CAJDM and for prospective studies on treatment of recalcitrant skin disease.
Comparative rna‐seq analysis of region‐specific miRNA expression in the epididymis of cattleyak
Authors: Zhao Wangsheng , Hussain Solangi Tajmal , Wu Yitao , Yang Xiankang , Xu Chuanfei , Wang Hongmei , Zheng Xuxin , Cai Xin , Zhu Jiangjiang 
Published: January 2021

AbstractThe epididymis is the site of post‐testicular sperm maturation, which constitutes the acquisition of sperm motility and the ability to recognize and fertilize oocytes. The role of miRNA in male reproductive system, including the control of different steps leading to proper fertilization such as gametogenesis, sperm maturation and maintenance of male fertility where the deletion of Dicer in mouse germ cells led to infertility, has been demonstrated. The identification of miRNA expression in a region‐specific manner will therefore provide valuable insight into the functional differences between the regions of the epididymis. In this study, we employed RNA‐seq technology to explore the expression pattern of miRNAs and establish some miRNAs of significant interest with regard to epididymal sperm maturation in the CY epididymis. We identified a total of 431 DE known miRNAs; 119, 185 and 127 DE miRNAs were detected for caput versus corpus, corpus versus cauda and caput versus cauda region pairs, respectively. Our results demonstrate region‐specific miRNA expression in the CY epididymis. The GO and KEGG enrichment for the predicted target genes indicated the functional values of miRNAs. Furthermore, we observed that the expression of miR‐200a was downregulated in the caput, compared with cauda. Since the family of miR‐200 has previously been suggested to contribute to the distinct physiological function of sperm maturation in epididymis of adult rat, we speculate that the downregulation of miR‐200a in CY caput epididymis may play an important role of sperm maturation in the epididymis of CY. Therefore, our findings may not only increase our understanding of the molecular mechanisms regulated by the miRNA functions in region‐specific miRNA expression in the CY epididymis, it could provide a valuable information to understand the mechanism of male infertility of CY.
Financial dollarization of households and firms: How does it differ by level of economic development?
Authors: Corrales Juan‐Sebastian , Imam Patrick Amir 
Published: January 2021

AbstractUsing a newly compiled and comprehensive database from International Financial Statistics, and applying panel‐regression techniques, this paper documents the evolution of households’ and firms’ dollarization over the past decade and assesses its macroeconomic determinants. Households’ and firms’ dollarization have much in common. Structural factors are more relevant than macroeconomic stability. Regarding differences, deposit dollarization, better institutions and lower inflation are relevant for households but not firms, whereas the exchange rate movements seem to play a role only for firms, particularly in higher‐income countries. In terms of loan dollarization, financial deepening is a critical driver for households only.
Mother's sense of coherence and dental characteristics in children and adolescents with osteogenesis imperfecta: A paired study
Authors: Teixeira Suélen Alves , Santos Paula Carolina Mendes , Carneiro Túlio Canella Bezerra , Paiva Saul Martins , Valadares Eugênia Ribeiro , Borges‐Oliveira Ana Cristina 
Published: January 2021

AbstractBackgroundThe relevance of sense of coherence (SOC) is important to the wellbeing of parents, especially mothers of children and adolescents with osteogenesis imperfecta (OI).ObjectiveDetermine whether the oral health status of children/adolescents with OI is associated with mother's SOC.Materials and methodA paired cross‐sectional study was conducted with 37 children/adolescents with OI, 37 without OI, and their respective mothers. The children/adolescents were between two and 19 years of age, mean age 7.2 years, being 47 male and 27 female. The mothers completed Antonovsky's SOC questionnaire (SOC‐13), and the oral status of the children/adolescents was investigated. The following clinical conditions were evaluated: dentinogenesis imperfecta, malocclusion, gingivitis, and dental caries experience.ResultsThe genetic condition of the children was significantly associated with mother's SOC (P < .001). Mothers of children with OI had lower SOC scores (mean: 35.6 [± 4.9]) than mothers of children without OI (mean: 38.5 [± 4.3]). In the group with OI, a low socioeconomic status was associated with lower mother's SOC scores (P = .004). In both groups, dental caries experience was associated with lower mother's SOC scores (P = .007). Most individuals with OI presented malocclusion (78.3%) and experience of dental caries (59.4%).ConclusionHaving a child with OI influenced the sense of coherence of the mothers. Socioeconomic status and dental caries experience in children and adolescents with OI were associated with mother's SOC.
Serum NT‐proBNP levels are associated with cognitive functions in hemodialysis patients
Authors: Akkus Gulsum , Seyithanoglu Muhammed , Akkus Hadi , Ulu Sena , Ciftcioglu Muhammed , Erken Ertugrul , Altunoren Orcun , Gungor Ozkan 
Published: January 2021

AbstractIt has been demonstrated that NT‐proBNP and macrophage inhibitor cytokine‐1 (MIC‐1/GDF‐15) are associated with cognitive functions in patients without renal disease. In the present study, we examined the association of these two molecules with cognitive functions in hemodialysis patients for the first time in the literature. A total of 94 patients were enrolled. The Mini‐Mental Test and the Montreal Cognitive Assessment Test (MoCA) were applied for the purpose of measuring the cognitive functions. The NT‐proBNP and MIC‐1/GDF‐15 levels were examined with the ELISA. The mean age of the patients was 48 ± 12; 58 (61.7%) of them were male and 21.3% were diabetic. We found that in 77% of patients have impaired cognitive functions (MoCA total score <24). The NT‐proBNP level had a significant and negative correlation with the MoCA Test Delayed Recall and Total Score. When the patients were divided into two groups according to NT‐proBNP levels (above 10.500 and below), it was observed that the Mini‐Mental Test Record Memory, MoCA Test Delayed Recall, and MoCA test total scores were significantly different from each other. In the present study, we show, for the first time in the literature, that NT‐proBNP levels are associated with cognitive functions in dialysis patients.
Formation, dispersion and accumulation of terra rossa on the Cayman Islands
Authors: Jones Brian 
Published: January 2021

AbstractUnconsolidated and lithified terra rossa fills surface depressions, joints, fractures and cavities throughout the karst landscapes on the Cayman Islands. The terra rossa is formed from kaolinite, halloysite, vermiculite, hydrotalcite, böhmite, gibbsite, goethite, hematite, anatase, quartz, calcite, dolomite, halite and X‐ray amorphous material. Locally, phosphate derived from bird guano and biofragments is present. Lithified terra rossa is characterized by numerous generations of fractures that are lined with clay and filled with multiple phases of calcite cement. There are no obvious geographic or stratigraphic differences between the terra rossa found on the three islands. A residual origin for the terra rossa is unlikely given that the Oligocene to Pleistocene limestone/dolostone bedrock contains <1% non‐carbonate material. Detrital sediments cannot be the source because none developed on these islands, given that they are surrounded by deep oceanic waters. The terra rossa probably originated largely from wind‐blown volcanic dust or Saharan dust. Various geochemical ratios and rare earth element profiles indicate that that the Cayman terra rossa has a strong affinity to Saharan dust that is frequently blown into the Caribbean region each year. The Cayman terra rossa is characterized by SiO2/Al2O3 ratios (<1.1) that are significantly lower than those associated with terra rossa on other islands, such as Jamaica and Barbados. The low SiO2/Al2O3 ratios of the Cayman terra rossa is due, at least in part, to the fact that quartz is rare to absent. X‐ray amorphous material is a common component in many of the Cayman samples. Although difficult to date precisely, the formation of terra rossa on the Cayman Islands appears to have been an ongoing process for at least the last 5 Myr. This time frame is consistent with the origin of the Sahara Desert that came into existence with aridification of North Africa about 5 Ma.
A new lack‐of‐fit test for quantile regression with censored data
Authors: Conde‐Amboage Mercedes , Van Keilegom Ingrid , González‐Manteiga Wenceslao 
Published: January 2021

AbstractA new lack‐of‐fit test for quantile regression models will be presented for the case where the response variable is right‐censored. The test is based on the cumulative sum of residuals, and it extends the ideas of He and Zhu (2003) to censored quantile regression. It will be shown that the empirical process associated with the test statistic converges to a Gaussian process under the null hypothesis and is consistent. To approximate the critical values of the test, a bootstrap mechanism will be used. A simulation study will be carried out to study the performance of the new test in comparison with other tests available in the literature. Finally, a real data application will be presented to show the good properties of the new lack‐of‐fit test in practice.
Measuring coarse grain deformation by digital image correlation
Authors: Silvani Claire , Réthoré Julien , Nicaise Sylvie 
Published: January 2021

AbstractThis work presents results from oedometric compression of coarse granular material. Coarse granular media exhibit significant deformations making it complicated to predict the settlement of structures. In this paper, a measurement technique was developed for the analysis of two‐dimensional (2‐D) images of a deforming coarse granular medium to investigate its deformation. This was achieved by realising grain‐based image correlation to measure the grain transformation in gravel with the use of a digital image correlation technique. The 2‐D displacement fields enable us to explore the behaviour of granular media at different scales: microscopic, mesoscopic and macroscopic scales. The mesoscopic scale is defined from branches that connect the centres of three neighbouring grains, using a Delaunay triangulation to account for an equivalent continuum media. Whereas the consistency of the macroscopic strain and the average mesoscopic strain is assessed, it is shown that a deviation from the normalised microscopic vertical displacement is an indicator of the heterogeneity of the mesoscopic strain field. The proposed mesoscopic analysis allows us to investigate these heterogeneities. Another important result is that even if the amplitude of the microscopic strain is small (approximately 100 times smaller) compared with the other strain measures, it confirms that the grains are not rigid and that their ultimate strain can be estimated using the proposed approach.
Donor‐derived herpes simplex virus hepatitis in a kidney transplant recipient and review of the literature
Authors: Zeidan Joseph H. , Casingal Vincent , Hippen Benjamin , Ahrens William , Lamm Kevin , Gerber David A. , Schmeltzer Paul A. , Gajurel Kiran 
Published: January 2021

AbstractDonor‐derived (DD) herpes simplex virus (HSV) hepatitis in solid organ transplant (SOT) recipients is extremely uncommon but carries a high mortality rate. The diagnosis is challenging due to the non‐specific presentation and lack of clinical suspicion. We report a case of DDHSV hepatitis in a HSV2 pre‐transplant seronegative kidney recipient who received the organ from a HSV2 seropositive donor. The case is highlighted by a few unusual features, namely severe thrombocytopenia and the development of cutaneous, oral and esophageal HSV lesions several weeks after symptom onset while recovering on appropriate treatment. A review of nine proven and probable DDHSV hepatitis cases (including eight previously published ones) showed that fever is a common presenting feature while gastrointestinal symptoms and cutaneous manifestations are uncommon. The symptoms almost always occurred within 2 weeks of transplant. Six out of the nine DDHSV hepatitis patients, including five patients who were on appropriate treatment, died within a month after transplant.
Gene atlas of iron‐containing proteins in Arabidopsis thaliana
Authors: Przybyla‐Toscano Jonathan , Boussardon Clément , Law Simon R. , Rouhier Nicolas , Keech Olivier 
Published: January 2021

SUMMARYIron (Fe) is an essential element for the development and physiology of plants, owing to its presence in numerous proteins involved in central biological processes. Here, we established an exhaustive, manually curated inventory of genes encoding Fe‐containing proteins in Arabidopsis thaliana, and summarized their subcellular localization, spatiotemporal expression and evolutionary age. We have currently identified 1068 genes encoding potential Fe‐containing proteins, including 204 iron‐sulfur (Fe‐S) proteins, 446 haem proteins and 330 non‐Fe‐S/non‐haem Fe proteins (updates of this atlas are available at https://conf.arabidopsis.org/display/COM/Atlas+of+Fe+containing+proteins). A fourth class, containing 88 genes for which iron binding is uncertain, is indexed as ‘unclear’. The proteins are distributed in diverse subcellular compartments with strong differences per category. Interestingly, analysis of the gene age index showed that most genes were acquired early in plant evolutionary history and have progressively gained regulatory elements, to support the complex organ‐specific and development‐specific functions necessitated by the emergence of terrestrial plants. With this gene atlas, we provide a valuable and updateable tool for the research community that supports the characterization of the molecular actors and mechanisms important for Fe metabolism in plants. This will also help in selecting relevant targets for breeding or biotechnological approaches aiming at Fe biofortification in crops.
Unveiling the spatial distribution of aflatoxin B1 and plant defense metabolites in maize using AP‐SMALDI mass spectrometry imaging
Authors: Righetti Laura , Bhandari Dhaka Ram , Rolli Enrico , Tortorella Sara , Bruni Renato , Dall’Asta Chiara , Spengler Bernhard 
Published: January 2021

SUMMARYIn order to cope with the presence of unfavorable compounds, plants can biotransform xenobiotics, translocate both parent compounds and metabolites, and perform compartmentation and segregation at the cellular or tissue level. Such a scenario also applies to mycotoxins, fungal secondary metabolites with a pre‐eminent role in plant infection. In this work, we aimed to describe the effect of the interplay between Zea mays (maize) and aflatoxin B1 (AFB1) at the tissue and organ level. To address this challenge, we used atmospheric pressure scanning microprobe matrix‐assisted laser desorption/ionization mass spectrometry imaging (AP‐SMALDI MSI) to investigate the biotransformation, localization and subsequent effects of AFB1 on primary and secondary metabolism of healthy maize plants, both in situ and from a metabolomics standpoint. High spatial resolution (5 µm) provided fine localization of AFB1, which was located within the root intercellular spaces, and co‐localized with its phase‐I metabolite aflatoxin M2. We provided a parallel visualization of maize metabolic changes, induced in different organs and tissues by an accumulation of AFB1. According to our untargeted metabolomics investigation, anthocyanin biosynthesis and chlorophyll metabolism in roots are most affected. The biosynthesis of these metabolites appears to be inhibited by AFB1 accumulation. On the other hand, metabolites found in above‐ground organs suggest that the presence of AFB1 may also activate the biochemical response in the absence of an actual fungal infection; indeed, several plant secondary metabolites known for their antimicrobial or antioxidant activities were localized in the outer tissues, such as phenylpropanoids, benzoxazinoids, phytohormones and lipids.
A prospective multi‐faceted interventional study of blood bank technologist screening of red blood cell transfusion orders: The START study
Authors: Kron Amie T. , Collins Allison , Cserti‐Gazdewich Christine , Pendergrast Jacob , Webert Kathryn , Lieberman Lani , Zeller Michelle P. , Harding Sheila R. , Nahirniak Susan , Prokopchuk‐Gauk Oksana , Lin Yulia , Mendez Brent , Armali Chantal , Lee Christina , Watson Danielle , Arnott Dena , Xun Fengju , Blain Heather , Panchuk Heather , Hughes Hertha , Chorneyko Kathy , Angers Michael , Pilutti Nicole , Lett Ryan , Dowsley Shauna , Ruijs Theodora , Cupido Tracy , Kichinko Tracy , Thompson Troy , Afshar‐Ghotli Zohreh , Callum Jeannie ,   University of Toronto Quality in Utilization, Education and Safety in Transfusion (QUEST) Research Program
Published: January 2021

AbstractBackgroundTransfusion of red blood cells (RBC) is a common procedure, which when prescribed inappropriately can result in adverse patient outcomes. This study sought to determine the impact of a multi‐faceted intervention on unnecessary RBC transfusions at hospitals with a baseline appropriateness below 90%.Study Design and MethodsA prospective medical chart audit of RBC transfusions was conducted across 15 hospitals. For each site, 10 RBCs per month transfused to inpatients were audited for a 5‐month pre‐ and 10‐month post‐intervention period, with each transfusion adjudicated for appropriateness based on pre‐set criteria. Hospitals with appropriateness rates below 90% underwent a 3‐month intervention which included: adoption of standardized RBC guidelines, staff education, and prospective transfusion order screening by blood bank technologists. Proportions of RBC transfusions adjudicated as appropriate and the total number of RBC units transfused per month in the pre‐ and post‐intervention period were examined.ResultsOver the 15‐month audit period, at the 13 hospital sites with a baseline appropriateness below 90%, 1950 patients were audited of which 81.2% were adjudicated as appropriate. Proportions of appropriateness and single‐unit orders increased from 73.5% to 85% and 46.2% to 68.2%, respectively from pre‐ to post‐intervention (P < .0001). Pre‐ and post‐transfusion hemoglobin levels and the total number of RBCs transfused decreased from baseline (P < .05). The median pre‐transfusion hemoglobin decreased from a baseline of 72.0 g/L to 69.0 g/L in the post‐intervention period (P < .0001). RBC transfusions per acute inpatient days decreased significantly in intervention hospitals, but not in control hospitals (P < .001). The intervention had no impact on patient length of stay, need for intensive care support, or in‐hospital mortality.ConclusionThis multifaceted intervention demonstrated a marked improvement in RBC transfusion appropriateness and reduced overall RBC utilization without impacts on patient safety.