bluuebunny/crossref_metadata_2025_split huggingface dataset:
In the Aftermath of School Victimization: Links Between Authoritative School Climate and Adolescents’ Perceptions of the Negative Effects of Bullying Victimization
Authors: Gee Kevin A. , Haghighat Misha D. , Vang Tseng M. , Cooc North 
Published: October 2021

AbstractAlthough authoritative school climate—strict, yet fair enforcement of rules alongside strong adult support—is associated with lower rates of bullying victimization, less is known about whether it influences how negatively adolescents feel after being victimized at school. Further, it is unclear whether boys and girls respond differently to an authoritative climate. Identifying ways that schools can reduce negative feelings after being bullied is important given the long term psychological ramifications of bullying that, if left unaddressed, can extend into adulthood. To address these gaps, this study examined whether authoritative school climate related to how negatively adolescents felt about their schoolwork, relationships, physical health and self-perception after being bullied. Differences between boys and girls were also investigated. Analyses were conducting using national data from the 2017 School Crime Supplement on a sample of 1,331 adolescents aged 12 to 18 years (Mage = 14.3 years; 59% girls). Findings from a set of ordinal regression models with a robust set of student, parent and school controls demonstrated that adolescents in more supportive schools were less likely to report that bullying victimization negatively impacted their schoolwork and feelings about themselves. Similar results were found for girls but not boys. By investing in supportive school climates, schools can be potentially transformative places where adolescents, especially girls, can feel more positively about themselves despite being bullied.
Molecular typing and epidemiologic profiles of human metapneumovirus infection among children with severe acute respiratory infection in Huzhou, China
Authors: Ji Lei , Chen Liping , Xu Deshun , Wu Xiaofang 
Published: October 2021

Abstract
Background
Human metapneumovirus (hMPV) is one of the important pathogens in infant respiratory tract infection. However, the molecular epidemiology of hMPV among children < 14 years of age hospitalized with severe acute respiratory infection (SARI) is unclear. We investigated the hMPV infection status and genotypes of children hospitalized with SARI from January 2016 to December 2020 in Huzhou, China.

Methods
A nasopharyngeal flocked swab, nasal wash, or nasopharyngeal swab/or opharyngeal swab combination sample was collected from children with SARI in Huzhou from January 2016 to December 2020. Quantitative reverse transcription-polymerase chain reaction was performed to detect hMPV RNA. The hMPV F gene was amplified and sequenced, followed by analysis using MEGA software (ver. 7.0). Epidemiological data were analyzed using Microsoft Excel 2010 and SPSS (ver. 22.0) software.

Results
A total of 1133 children with SARI were recruited from 2016 to 2020. Among them, 56 (4.94%) were positive for hMPV-RNA. Children < 5 years of age accounted for 85.71% of the positive cases. The hMPV incidence was high in spring and winter, especially in December and January to March. Phylogenetic analysis of the F-gene sequences of 28 hMPV strains showed that the A1, B1, and B2 genotypes were prevalent in Huzhou, and the dominant hMPV genotype varied according to surveillance year.

Conclusions
HMPV is an important respiratory pathogen in children in Huzhou, with a high incidence in winter and spring in children < 5 years of age. In this study, genotypes A1, B1, and B2 were the most prevalent.
Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions
Authors: Hanke Nina , Gómez-Mantilla José David , Ishiguro Naoki , Stopfer Peter , Nock Valerie 
Published: October 2021

Abstract
Purpose
To build a physiologically based pharmacokinetic (PBPK) model of the clinical OATP1B1/OATP1B3/BCRP victim drug rosuvastatin for the investigation and prediction of its transporter-mediated drug-drug interactions (DDIs).

Methods
The Rosuvastatin model was developed using the open-source PBPK software PK-Sim®, following a middle-out approach. 42 clinical studies (dosing range 0.002–80.0 mg), providing rosuvastatin plasma, urine and feces data, positron emission tomography (PET) measurements of tissue concentrations and 7 different rosuvastatin DDI studies with rifampicin, gemfibrozil and probenecid as the perpetrator drugs, were included to build and qualify the model.

Results
The carefully developed and thoroughly evaluated model adequately describes the analyzed clinical data, including blood, liver, feces and urine measurements. The processes implemented to describe the rosuvastatin pharmacokinetics and DDIs are active uptake by OATP2B1, OATP1B1/OATP1B3 and OAT3, active efflux by BCRP and Pgp, metabolism by CYP2C9 and passive glomerular filtration. The available clinical rifampicin, gemfibrozil and probenecid DDI studies were modeled using in vitro inhibition constants without adjustments. The good prediction of DDIs was demonstrated by simulated rosuvastatin plasma profiles, DDI AUClast ratios (AUClast during DDI/AUClast without co-administration) and DDI Cmax ratios (Cmax during DDI/Cmax without co-administration), with all simulated DDI ratios within 1.6-fold of the observed values.

Conclusions
A whole-body PBPK model of rosuvastatin was built and qualified for the prediction of rosuvastatin pharmacokinetics and transporter-mediated DDIs. The model is freely available in the Open Systems Pharmacology model repository, to support future investigations of rosuvastatin pharmacokinetics, rosuvastatin therapy and DDI studies during model-informed drug discovery and development (MID3).
Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis
Authors: Upadhyay Parth J. , Vet Nienke J. , Goulooze Sebastiaan C. , Krekels Elke H. J. , de Wildt Saskia N. , Knibbe Catherijne A. J. 
Published: October 2021

Abstract
Aim
In critically ill mechanically ventilated children, midazolam is used first line for sedation, however its exact sedative effects have been difficult to quantify. In this analysis, we use parametric time-to-event (PTTE) analysis to quantify the effects of midazolam in critically ill children.

Methods
In the PTTE analysis, data was analyzed from a published study in mechanically ventilated children in which blinded midazolam or placebo infusions were administered during a sedation interruption phase until, based on COMFORT-B and NISS scores, patients became undersedated and unblinded midazolam was restarted. Using NONMEM® v.7.4.3., restart of unblinded midazolam was analysed as event. Patients in the trial were divided into internal and external validation cohorts prior to analysis.

Results
Data contained 138 events from 79 individuals (37 blinded midazolam; 42 blinded placebo). In the PTTE model, the baseline hazard was best described by a constant function. Midazolam reduced the hazard for restart of unblinded midazolam due to undersedation by 51%. In the blinded midazolam group, time to midazolam restart was 26 h versus 58 h in patients with low versus high disease severity upon admission (PRISM II < 10 versus > 21), respectively. For blinded placebo, these times were 14 h and 33 h, respectively. The model performed well in an external validation with 42 individuals.

Conclusion
The PTTE analysis effectively quantified the effect of midazolam in prolonging sedation and also the influence of disease severity on sedation in mechanically ventilated critically ill children, and provides a valuable tool to quantify the effect of sedatives.
Clinical trial number and registry URL: Netherlands Trial Register, Trial NL1913 (NTR2030), date registered 28 September 2009 https://www.trialregister.nl/trial/1913.
Accounting for uncertainty: an application of Bayesian methods to accruals models
Authors: Breuer Matthias , Schütt Harm H. 
Published: October 2021

AbstractWe provide an applied introduction to Bayesian estimation methods for empirical accounting research. To showcase the methods, we compare and contrast the estimation of accruals models via a Bayesian approach with the literature’s standard approach. The standard approach takes a given model of normal accruals for granted and neglects any uncertainty about the model and its parameters. By contrast, our Bayesian approach allows incorporating parameter and model uncertainty into the estimation of normal accruals. This approach can increase power and reduce false positives in tests for opportunistic earnings management as a result of better estimates of normal accruals and more robust inferences. We advocate the greater use of Bayesian methods in accounting research, especially since they can now be easily implemented in popular statistical software packages.
Implementing the Variability of Crystal Surface Reactivity in Reactive Transport Modeling
Authors: Prill Torben , Fischer Cornelius , Gavrilenko Pavel , Iliev Oleg 
Published: October 2021

AbstractCurrent reactive transport model (RTM) uses transport control as the sole arbiter of differences in reactivity. For the simulation of crystal dissolution, a constant reaction rate is assumed for the entire crystal surface as a function of chemical parameters. However, multiple dissolution experiments confirmed the existence of an intrinsic variability of reaction rates, spanning two to three orders of magnitude. Modeling this variance in the dissolution process is vital for predicting the dissolution of minerals in multiple systems. Novel approaches to solve this problem are currently under discussion. Critical applications include reactions in reservoir rocks, corrosion of materials, or contaminated soils. The goal of this study is to provide an algorithm for multi-rate dissolution of single crystals, to discuss its software implementation, and to present case studies illustrating the difference between the single rate and multi-rate dissolution models. This improved model approach is applied to a set of test cases in order to illustrate the difference between the new model and the standard approach. First, a Kossel crystal is utilized to illustrate the existence of critical rate modes of crystal faces, edges, and corners. A second system exemplifies the effect of multiple rate modes in a reservoir rock system during calcite cement dissolution in a sandstone. The results suggest that reported variations in average dissolution rates can be explained by the multi-rate model, depending on the geometric configurations of the crystal surfaces.
Natural regeneration responses to thinning and burning treatments in ponderosa pine forests and implications for restoration
Authors: Wasserman Tzeidle N. , Waltz Amy E. M. , Roccaforte John Paul , Springer Judith D. , Crouse Joseph E. 
Published: October 2021

AbstractUnderstanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment, but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition. A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United States. The focus was on site-specific variability in pine regeneration dynamics, temporal trends in regeneration presence and abundance, and response to treatment as described in the current literature using 29 studies that met our evidence-based review protocols. Data showed that the effects of thinning and burning treatments on regeneration depended on time since treatment. Mechanical thinning, prescribed burning, and thinning plus burn treatments all increased seedling density, but there was high variability among sites and studies. There were mixed results in the short-term (< 10 years) with both increasing and decreasing regeneration, and a general increase in regeneration 11 − 20 years post-treatment. Some long-term studies (> 20 years) concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments applied. Several studies showed the average ponderosa pine seedling presence, survival and growth found in today’s forests to be at a high density; this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.
Development and Validation of a Short Questionnaire on Dietary and Physical Activity Habits for Patients Submitted to Bariatric Endoscopic Therapies
Authors: Miranda-Peñarroya Gemma , Vallejo-Gracia Marta , Ruiz-León Ana-Maria , Saenger-Ruiz Fernando , Sorio-Fuentes Ricardo , Izquierdo-Pulido Maria , Farran-Codina Andreu 
Published: October 2021

Abstract
Purpose
Individuals with obesity frequently regain weigh after endoscopic bariatric therapies (EBT) unless they adhere to healthy habits. The objective was to create and validate a short, self-administered questionnaire (EMOVE) to assess healthy dietary and physical activity (PA) habits’ adherence to be used in clinical practice.

Materials and Methods
In this prospective, unicentric study, 463 patients completed the short, Spanish EMOVE questionnaire, to be validated following the Medical Outcome Trust Criteria. Conceptual and measurement model, reliability (internal consistency and test–retest [subgroup of 93 patients]), construct validity, responsiveness, interpretability, and burden were evaluated. Patients enrolled from January 2017 through August 2018 and auto-filled the EMOVE at baseline and at 3, 6, and 12 months.

Results
Patients submitted to intragastric ballon for 6 and 12 months or POSE were 82.7% women with a mean age of 42.7 years, and a mean BMI of 37.1 kg/m2. Four factors were extracted with exploratory factor analysis related to intake frequency, portions and proportions, time and place of eating, and physical activity. EMOVE showed adequate internal consistency (α = 0.73), very good test–retest (r = 0.91, CI: 0.86–0.94; p < 0.001), moderate construct validity of dietary (r = 0.24, CI: 0.11–0.37, p < 0.001), and PA habits (r = 0.44, CI 0.30–0.58; p < 0.001). Stable responsiveness, with correlations from 0.29 to 0.39 (p < 0.001) between the EMOVE scores and the % of total weight loss at 3, 6, and 12 months. Participants categorized as having good or excellent habits (score ≥ 30 points) lost significantly more weight (p < 0.05). Finally, the administration burden was 2.96 min.

Conclusion
The EMOVE is a useful tool in Spanish language to easily assess the level of adherence to healthy dietary and PA habits to be used routinely in clinical practice.

Graphical abstract
Systemic Therapy for Metastatic Pancreatic Cancer
Authors: Ettrich Thomas J. , Seufferlein Thomas 
Published: October 2021

Opinion statementPancreatic cancer is mainly diagnosed at an advanced, often metastatic stage and still has a poor prognosis. Over the last decades, chemotherapy of metastatic pancreatic cancer (mPDAC) has proven to be superior to a mere supportive treatment with respect to both survival and quality of life. Recently, even sequential treatment of mPDAC could be established. Options for first-line treatment are combination chemotherapy regimens such as FOLFIRINOX and gemcitabine plus nab-paclitaxel when the performance status of the patient is good. For patients with poorer performance status, gemcitabine single-agent treatment is a valid option. Recently, the PARP inhibitor olaparib has been demonstrated to improve progression-free survival when used as a maintenance treatment in the subgroup of patients with mPDAC and a BRCA1/-2 germ line mutation having received at least 16 weeks of platinum-based chemotherapy. This group of patients also benefits from platinum-based chemotherapy combinations. Therefore, the BRCA1/-2 stats should be examined early in patients with mPDAC even when the occurrence of these mutations is only about 5% in the general Caucasian population. After the failure of first-line treatment, patients should be offered a second-line treatment if their ECOG permits further treatment. Here, the combination of 5-FU/FA plus nanoliposomal irinotecan has shown to be superior to 5-FU/FA alone with respect to overall survival. Immune checkpoint inhibitors like PD1/PD-L1 mAbs are particularly efficacious in tumors with high microsatellite instability (MSI-h). Limited data in mPDACs shows that only a part of the already small subgroup of MSI-H mPDACs (frequency about 1%) appears to benefit substantially from a checkpoint inhibitor treatment. The identification of further subgroups, e.g., tumors with DNA damage repair deficiency, gene fusions, as well as novel approaches such as tumor-organoid-informed treatment decisions, may further improve therapeutic efficacy.
Shear orientation of nematic phases of clay nanosheets: processing of barrier coatings
Authors: Röhrl Maximilian , Mettke Judith H. , Rosenfeldt Sabine , Schmalz Holger , Mansfeld Ulrich , Timmins Renee L. , Habel Christoph , Breu Josef , Durst Franz 
Published: October 2021

AbstractWhen suspensions are exposed to shear forces, the particles may form ordered structures depending on their shapes, concentrations, and the material. For some processes, e.g., for wet-film coating, it is important to know how fast these structures form in shear fields and for how long the structures persist when the shear is relaxed. To obtain information on the particle structure formation and the decay time, the effective viscosity of nematic suspensions of Na-hectorite nanosheets was investigated by rheology employing a cone-plate measurement geometry. The necessary time for the formation textured nematic films could be deduced by carrying out effective viscosity measurements at constant time steps. Information could also be obtained on the lifetime of the platelet textures when shear is relaxed. All this information was employed to identify geometrical requirements for slot dies to produce barrier liners with nanosheet layers oriented parallel to PET substrates. Thereby, we obtained green and simple coatings that are in line with state-of-the-art high-performance materials such as metalized plastic foils in terms of oxygen barrier properties.
Acromegaly disease activity according to ACRODAT®, a cross-sectional study in Spain: ACROVAL study
Authors: Marazuela Mónica , Blanco Concepción , Bernabeu Ignacio , Menendez Edelmiro , Villar Rocío , Paja Miguel , Sampedro-Nuñez Miguel , Samaniego M. Luz , Díaz-Muñoz Marcos , Sánchez-Cenizo Laura 
Published: October 2021

AbstractObjectivesTo evaluate disease activity status using the Acromegaly Disease Activity Tool (ACRODAT®) in a cohort of Spanish acromegaly patients, to assess the relationship between the level of disease activity according to both ACRODAT®and the physicians’ clinical evaluation, and to study the potential discrepancies in the perception of symptoms between physicians and patients.DesignMulticenter, observational, descriptive and cross-sectional study.MethodsDisease activity was assessed in adult patients with acromegaly under pharmacological treatment during at least 6 months using ACRODAT®.ResultsAccording to ACRODAT®, 48.2%, 31.8% and 20.0% of a total of 111 patients were classified as having a stable disease (S), mild disease activity (M-DA) and significant disease activity (S-DA) respectively. ACRODAT®classification of disease activity significantly correlated with physicians’ opinion, with a moderate inter-rater agreement and a specificity of 92.45% (PPV = 86.21%). No correlation was found between IGF-I levels and severity of symptoms or quality of life (QoL). A decision to take clinical action was significantly more frequent in S-DA and M-DA patients than S patients but no action was taken on 5 (22.7%) and 27 (77.1%) S-DA and M-DA patients, respectivelyConclusionsACRODAT®detected disease activity in 51.8% of patients. Interestingly, although M-DA and S-DA patients were likely to be in the process of being controlled, action was not always taken on these patients. ACRODAT®is a validated and highly specific tool that may be useful to routinely monitor acromegaly and to identify patients with non-obvious disease activity by incorporating “patient-centred” parameters like symptoms and QoL to the clinical evaluation of acromegaly.
Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group
Authors: Guirado M. , Sanchez-Hernandez A. , Pijuan L. , Teixido C. , Gómez-Caamaño A. , Cilleruelo-Ramos Á. 
Published: October 2021

AbstractMultidisciplinary care is needed to decide the best therapeutic approach and to provide optimal care to patients with lung cancer (LC). Multidisciplinary teams (MDTs) are optimal strategies for the management of patients with LC and have been associated with better outcomes, such as an increase in quality of life and survival. The Spanish Lung Cancer Group has promoted this review about the current situation of the existing national LC-MDTs, which also offers a set of excellence requirements and quality indicators to achieve the best care in any patient with LC. Time and sufficient resources; leadership; administrative and institutional support; and recording of activity are key factors for the success of LC-MDTs. A set of excellence requirements in terms of staff, resources and organization of the LC-MDT have been proposed. At last, a list of quality indicators has been agreed to achieve and measure the performance of current LC-MDTs.
Valorization of granite micronized stones wastes for eco-friendly production of fired clay bricks
Authors: Ngayakamo Blasius , Komadja Gbetoglo Charles , Bello Abdulhakeem , Onwualu Azikiwe Peter 
Published: October 2021

AbstractConstruction and mining industries around the globe have been criticized for production of enormous solid wastes that have potential environmental impacts. Therefore, this study presents a feasible approach to recover and utilize granite micronized stones waste for production of eco-friendly bricks. This research work, aimed at substituting a natural clay with granite powder to produce value-added bricks with pronounced physical–mechanical properties. The micronized granite waste stones were crushed and ground to obtain a fine powder sample. Thereafter, different batch compositions containing a varied proportions of granite powder were prepared and fired at different sintering temperatures: 900, 1000 and 1100 °C. The raw materials and bricks were characterized for their chemical compositions, microstructural, mineralogical and physical–mechanical properties. The results showed that, an increase in granite waste powder and sintering temperature enhanced the quality of fired clay bricks in terms of mechanical strength and decreased simultaneously the apparent porosity and water absorption. The final experimental approach showed that, the possibility to produce eco-friendly bricks containing up to 30 wt% of granite powder with enhanced engineering properties fired at 1100 °C is promising.
Graphic abstract