bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Safety and Applicability of Laparoscopic vs Open Non Anatomical Resection of Hepatocellular Carcinoma in Cirrhotic Patients
Authors: Mohammed Mohammed Mahfouz , Basset Hany Saeed Abdel , Elsayed Mohammed Abd Almegeed , Hegazi Ahmed Abdel Basset 
Published: October 2021

Abstract

Background
Laparoscopic liver resection (LLR) has been progressively developed along the past two decades. Liver surgery was one of the last frontiers reached by minimally invasive surgery. Surgical technique and equipment evolved to overcome technical limitations, making laparoscopic liver resections (LLR) safe and feasible. Surgeons developed skills in a stepwise approach, beginning with low complexity operations for benign diseases and reaching high-complexity surgeries for malignant cases and living donor organ harvesting.

Objective
s: The aim of the study is to compare short term results of laparoscopic versus open hepatectomy regarding to intra operative details and post-operative management and complications for achieving a safe hepatic resection for treatment of HCC in cirrhotic patients.

Patients and Methods
In this prospective study, a comparison between laparoscopic resection and open resection was done to compare short-term results between laparoscopic and open liver resection. This study was conducted on 30 patients with hepatocellular carcinoma. 15 patients (50%) were treated by laparoscopic liver resection (Group A) while the other 15 patients (50%) were treated by open liver resection (Group B).

Results
Regarding the demographic data, the presence of past history of medical condition and the preoperative laboratory results, no statistical significance was found. The mean operative time has statistically significant difference between the 2 groups, with decreased operative time in the laparoscopic group (P &lt; 0.001). The mean blood loss has no statistically significant difference relations between the 2 groups, (P = 0.866) with conversion rate of (13.3%) happened in two cases.

Conclusion
Laparoscopic liver resection is a safe and feasible treatment option for HCC in cirrhotic patient needing minor resection at laparoscopic segments (II, III, IVa,V,VI). Laparoscopic liver resection for HCC has superior short- term and comparable oncological outcomes to open liver resection. LLR should be performed for carefully selected patients and by an expert surgical team.
Surgical Management of Early Hepatocellular Carcinoma
Authors: Ewada Adel Abdel Aziz , Mohamed Sherif Boraii , Marie Alshimaa Khalil Abdelmonem 
Published: October 2021

Abstract

Background
Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy ranking sixth in the world among all malignancies and becoming the third cause of death due to cancer. Incidence has increased all over the world, mainly because of increase in the incidence of chronic hepatitis B (HBV) and hepatitis C (HCV) infections

Objective
To study hepatocellular carcinoma in terms of pathogenesis, staging and diagnosis as well as discuss its surgical management and follow up afterwards.

Patients and Methods
Design: Prospective, comparative study. Setting: NHTMRI (national hepatology and tropical medicine research institute). Study duration: Period 3 years from April 2017 - April 2020. Patients: A total of 50 early HCC patients enrolled in the study.

Results
After applying (Forward method) and entering some predictor variables; the increase in operative time; had an independent effect on increasing ICU stay (p &lt; 0.01). After applying (Forward method) and entering some predictor variables; the increase in age and operative time; had an independent effect on increasing drain removal days (p &lt; 0.05 respectively).

Conclusion
Laparoscopic liver resection (LLR) is now considered a feasible alternative to open liver resection (OLR) in selected patients. Nevertheless studies comparing LLR and OLR are few and concerns remain about long-term oncological equivalence. LLR has short-term advantages and seemingly equivalent long-term outcomes and can be considered a feasible alternative to open surgery in experienced hands.
White test versus conventional saline test in detecting intra-operative bile leakage in liver resection
Authors: Wagdi Hesham Hasan , Khalil Ahmed , Saber Hatem Sayed , Gamal Elden Karim Mohamed 
Published: October 2021

Abstract

Background
Hepatic surgery will be always one of the most challenging surgical procedures due to its anatomical and pathophysiologic varieties. Various problems may complicate the post-operative course. Bile leak remains a serious complication after hepatectomy. Bile leaks can significantly impact morbidity, mortality, and cost of treatment. Bile leak increases risk of sepsis, need for further intervention, either radiological or return to theatre, prolongs duration of intensive care unit and hospital stay, and can precipitate liver failure and death.

Objective
To assess the post-operative bile leak complication after using white test versus conventional saline test

Patients and Methods
A prospective study on 50 Hepatectomy cases divided into two groups, the first group consist of 25 cases using white test and the second group consist of 25 cases using conventional saline test from January 2019 to January 2020, at Hepatobiliary unit of the general surgery department of Ain Shams university hospitals.

Results
The White test has clear advantages in comparison with other bile leakage tests: it precisely detects bile leakages, regardless of size; it does not stain the resection surface, allowing it to be washed off and repeated ad infinitum; and it is safe, quick, and inexpensive. The white test is a feasible and sensitive bile leakage test with no obvious disadvantages. It could be a possible standardized method to prevent bile leakage in major liver resection.

Conclusion
Now after we discussed our study and reviewed other opinions discussing the optimal methods for intraoperative bile leakage testing, we have now settled on White test using fat emulsion solution to be best of all tests.
Gastric Bypass versus Sleeve Gastrectomy in Morbid Obesity Management
Authors: Gawdat Khaled A , El Shayeb Basem H , Naguib Kerolos R 
Published: October 2021

Abstract

Background
Obesity is caused by a combination of excessive food energy intake, lack of physical activity, and genetic susceptibility, although a few cases are caused primarily by genes, endocrine disorders, medications, or psychiatric illness. The main aim of obesity therapy is weight loss and maintenance by dietary interventions and increased physical activity.

Aim of the Work
to review two of the most commonly performed modalities of weight loss namely Sleeve Gastrectomy, Gastric Bypass, and to study their early post-operative complications, outcomes, effects regarding excess body weight loss (EBWL), life style changes and sustainability.

Patients and Methods
This is a prospective comparative randomize study included 40 patients presented with morbid obesity with BMI range between (40 to 60 kg/m2) were treated 20 cases by laparoscopic sleeve Gastrectomy and 20 cases by laparoscopic Gastric Bypass (15 cases one anastomosis gastric bypass – 5 cases Roux-en-Y bypass) in Ain Shams Hospital during the period from October 2017 till May 2018. Cases were followed up monthly for 6 months and after 1 year.

Results
Laparoscopic sleeve gastrectomy has higher incidence of complications (15%) than the incidence of complications of Laparoscopic Gastric Bypass (5%).

Conclusion
Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass are both safe and effective procedures for the surgical management of morbid obesity. Laparoscopic Gastric Bypass has slightly higher mean of (EBWL%) than Laparoscopic sleeve gastrectomy at 6 months, and a higher mean of (EBWL%) than Laparoscopic sleeve gastrectomy at 1 year follow up.
Round Block Technique versus Grisotti Technique in Juxta Areolar Breast Cancer
Authors: Shehab Mohamed Ahmed Helmy , Elmoaty Karim Fahmy Abd , Elsebaai Mahmoud Refaat Mohamed 
Published: October 2021

Abstract

Background
Breast cancer is the most common cancer in women all over the world representing 18% of all women reported cases of cancer. It represents the leading cause of women mortality as representing 23% of all women cancer deaths.

Objectives
To compare aesthetic and surgical outcome of Round block technique and Grisotti technique in juxta areolar breast cancer.

Patients and Methods
In our study 20 breast cancer patients are subdivided into group (A) 10 females which underwent round block technique and group (B) 10 femaleswhich underwent grisotti technique. Patient and tumor criteria including age, co morbidities, tumor size and distance between tumor and nipple-areola complex were considered to be nonsignificant between 2 groups so the only difference is the surgical technique.

Results
The study shows that the round block technique and grisotti technique have the same results regarding operative time, intra-operative blood loss, post operative complications and re-excision rates with slight advantage to round block technique because of its slightly better cosmetic outcomes. So, the round block technique is slightly preferred for selected cases.

Conclusion
When to compare between round block technique and grisotti technique In treatment of juxta areolar breast cancer, there in no evident difference in operating time, post operative complications or need of re-excision between these two groups of patients
Blind Comparative study between Silver nanoparticles dressings and Standard Moist Wound Dressings (SMWD) in management of diabetic foot ulcers
Authors: Abdelaal Amr , Soliman Mostafa , Rafik Hany , Emam Mohamed , Mohamed Elsadek Mohamed Mahmoud 
Published: October 2021

Abstract

Background
Diabetic foot ulcers (DFUs) are the main cause of hospitalization in diabetic patients and they are considered a major worldwide health problem. Thus, there is a need to evaluate various treatment modalities. In this study we will assess the clinical efficacy of Silver nanoparticles dressing vs Standard Moist Wound Dressing (SMWD) in management of diabetic foot ulcers.

Objective
To compare wound outcome, limb salvage, healing time of diabetes related foot ulcers and cost effectiveness in terms of duration of hospital stay between Silver nanotechnology dressings and Standard moist wound therapy (SMWT) in management of diabetic foot ulcers.

Patients and Methods
This is a prospective randomized controlled study involving 34 patients with active diabetic foot ulcers, in a high volume tertiary referral vascular center. They were divided into 2 groups: 17 patients (group A) were prescribed SMWD and the other 17 patients (group B) received Silver nanoparticles wound dressing.

Results
Our study correlates with the study conducted by K.Suhas et al. which had observed that Silver nanoparticles wound dressing was safe and effective treatment for complex diabetic foot wounds and could lead to higher proportion of healed wounds and faster healing rates. At the end of the study, group B promised a better outcome as compared to group A.

Conclusion
The role of Silver nanoparticles wound dressing in healing of diabetic foot ulcers has been proposed as a novel method of manipulating the chronic wound environment in a way that it reduces bacterial burden and chronic interstitial wound fluid, increases vascularity and cytokine expression and to an extent mechanically exploiting the viscoelasticity of peri wound tissues.
Role Of Laparoscopy In Blunt Abdominal Trauma: A Comparative Prospective Cohort Study Between Laparoscopy And Laparotomy In Patients With Blunt Abdominal Trauma
Authors: Ouf Tarek Ismail , ElShinawi Mohamed ElSayed , Abbas Ahmed Adel , El Sayed Nagy Mostafa 
Published: October 2021

Abstract

Background
Trauma is considered to be the main leading cause of death in young adults under 35 years old. Blunt mechanisms accounts for about 95% of injuries. Generally, laparotomy is considered to be the standard procedure used in the trauma cases. Recently, laparoscopic techniques have been increasingly introduced as an alternative to open surgery in trauma cases. This study aims to assess the efficacy of Laparoscopy in management of patients with Blunt abdominal trauma in order to avoid unnecessary laparotomies.

Objective
To investigate the effectiveness and role of laparoscopy in the management of blunt abdominal trauma patients.

Patients and Methods
Observational prospective cohort study. Ain Shams University Surgery Hospital. All isolated blunt abdominal trauma patients at Ain Shams University Surgery hospital from 1/3/2019 to 1/9/2019. Eligibility and exclusion criteria applied as following:

Eligibility criteria
All patients with blunt abdominal trauma presented to ASUH. Patients with class I &class II according to ATLS guidelines for hemorrhagic shock in trauma patients. Patients aged 18 years old or above. Exclusion criteria: Patients with class III &class IV according to ATLS guidelines for hemorrhagic shock in trauma patients. Pregnant patients. Patients with old trauma presented after 24 hours. Patients discharged on demand.

Results
Laparoscopy decreased the operative time in comparison with laparotomy, the mean operative time for patients underwent laparoscopy is 123.28 minutes while in patients underwent laparotomy is 150.48. Also, time to pass gas post operative after laparoscopy is 1-3 days compared to 2-4 days after laparotomy which is in favor of laparoscopy which is associated with rapid recovery of patients. Laparoscopy is associated with decreased post operative ICU stay (1-3) days in comparison with Laparotomy (2-5) days and decreased total hospital stay. The rate of complications after laparoscopy is much less than after laparotomy, 2 patients with respiratory tract infections after laparoscopy and no mortality while six patients with respiratory tract infections, 6 patients with wound infection, one patient with deep venous thrombosis and 2 patients died after laparotomy.

Conclusion
Laparoscopy is found to be a good alternative to laparoscopy, as it is considered to be reliable and safe as a diagnostic and treatment method in hemodynamically stable patients with blunt abdominal trauma, it can be used to reduce the laparotomy rate, and it is associated with lower morbidity and mortality.
Reconstructive Techniques of Primary Distal Penile Hypospadias: A Meta-Analysis Study of Last 10 Years
Authors: Mohammad Omar Goda Hassan , Reyad Khaled Ahmed Mahmoud , Ali Hassan Ahmed , Abdelgawad Osama Fouad Mohamed 
Published: October 2021

Abstract

Background
Hypospadias is one of the most common congenital anomalies affecting males worldwide, with distal variants representing up to 70% of all cases. Several surgical techniques are adopted for distal hypospadias repair. However, there is still much controversy about the ideal technique.

Objectives
The aim of this study is to compare between the most popular reconstructive techniques for distal penile hypospadias repair. Highlighting their effectiveness, in term of success rate as well as the risk of postoperative complications.

Methods
For this systematic review, PubMed/Medline and ScinceDirect online databases were searched using the keywords ‘distal hypospadias, complications and outcome’. Inclusion criteria were primary repairs; distal hypospadias; pediatric case series and standard techniques. Abstracts of articles identified were reviewed, and then relevant articles were retrieved in full. Papers were only included if data on at least one of the main outcome measures was obtainable, which are postoperative fistula, meatal stenosis and glanular dehiscence. Data were pooled using CMA software, effect sizes were reported as event rates with 95% confidence intervals (CI) been calculated for each outcome.

Results
A total of 25 studies, which included 4572 patients, met the inclusion criteria. The tubularised incised plate (TIP) was the most commonly adopted procedure followed by the peri-meatal flap (Mathieu). Few studies reported data for other techniques like onlay flap, Thiersch-Duplay, meatal advancement and MAGPI procedures, in addition to urethral mobilization technique. The overall incidence of main complications was 10.5% with comparable results among different techniques. The results are in favor of urethral mobilization and TIP procedures over Mathieu regarding the incidence of both meatal stenosis and post-operative fistula. Overall, the quality of the included studies was determined to be satisfactory.

Conclusion
Compared with Mathieu technique, urethral mobilization and the TIP procedure for distal penile hypospadias (DPH) reconstruction were associated with a lower risk of overall complications specifically postoperative fistula and meatal stenosis.
A Histological study on the effect of Platelet Rich Plasma on Hair Growth in Male Albino Rat Model of Androgenic Alopecia
Authors: Nada Hoda Fouad , ElSebay Sarah Abdel Gawad , El-Waseef Dalia Alaa El-Din Aly , Saad Nancy Sultan 
Published: October 2021

Abstract

Background
Androgenetic alopecia (AGA) is the commonest cause of hair loss in men with limited treatment options. Platelet-rich plasma (PRP) is defined as an autologous concentration of plasma with a greater count of platelets than that of whole blood. Its action depends on the released growth factors from platelets. It has been investigated and used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss.

Aim of the work
This study aimed at evaluating the efficacy of PRP therapy on experimentally induced AGA in male albino rats.

Materials and Methods
Eighteen rats were divided into 3 groups - Group I (the control group), Group II (testosterone group): rats were injected 0.1 ml testosterone daily in the shaved area of the dorsum , Group III (PRP group): rats were injected 0.1 ml of testosterone daily+ 0.1 ml of PRP every 3 days in the shaved area of their dorsum. After 21 days from the start of the experiment, skin samples were collected from the site of injection and prepared for histological examination by hematoxylin and eosin stain and immunohistochemical examination by anti Ki 67. Morphometrical and statistical analysis were performed.

Results
Testosterone group when compared to the control group showed a significant decrease in the mean epidermal thickness, decreased mean number of anagen hair follicles, increase in the mean number of telogen hair follicles and decreased anagen/telogen ratio, all were statistically significant (P &lt; 0.05). PRP group showed significant increase in the mean number of anagen hair follicles (p &lt; 0.05), and a decrease in the mean number of telogen hair follicles (p &lt; 0.05). This resulted in an increase in anagen/telogen ratio. There was also a significant increase in the mean epidermal thickness in the PRP group as compared to the other groups (p &lt; 0.05). Immunohistochemical examination of anti Ki 67 stained sections showed significant decrease of the mean number of Ki 67 positive basal epidermal cells (P &lt; 0.05) in the testosterone group compared to control group, and an increase in the mean number of Ki 67 positive basal epidermal cells in the PRP group (p &lt; 0.05) as compared to the control group and the testosterone group.

Conclusion
Our data suggest that PRP injections may have a positive therapeutic effect on experimentally induced androgenic alopecia in adult male albino rats.
Study of serum Fetuin-A level in pateints with post HCV liver cirhosis with and without hepatocellular carcinoma
Authors: Mohamed Mansour N , Yousry Wael A , Soliman Mohamed L , Zaki Khalid A , Tawfik Abdalla M 
Published: October 2021

Abstract

Background
Measurement and assessment of the levels of glycoprotein as fetuin-A which provides insights into the pathogenic mechanisms of various liver diseases and improved capability to identify disease- specific profiles of proteins leads to more accurate prediction of disease classes and development of novel treatments.

Aim of the work
Assessment of diagnostic value of Fetuin –A in cases of liver cirrhosis due to HCV with and without HCC.

Patients and methods
This study was conducted at the Internal Medicine, Faculty of Medicine, Zagazig University, during the period from November 2014 to Decmeber 2015 on 80 patients with liver cirrhosis due to chronic HCV infection. Two groups of post HCV patients with liver cirrhosis as a first group & post HCV liver cirrhosis with HCC as a second group; each group included 40 patients. The study also included 20 healthy subjects as a control. Patients who were excluded, those who had received antiviral therapy within 6 months before the study, subjects with high triglyceride or had received lipid lowering drugs, HBV infected patients, patients with medical history of ESRD, diabetes mellitus.

Results
fetuin A was significantly lower in post HCV liver cirrhosis than a healthy control cases, fetuin-A was significantly lower in post HCV liver cirrhosis with HCC versus post HCV liver cirrhotic patients. Serum levels of fetuin A was a useful marker in post HCV liver cirrhosis with HCC, with AFP levels below cutoff value. Serum levels of AFP was a useful marker in post HCV liver cirrhosis with HCC, with fetuin-A levels above cutoff value.

Conclusion
Serum fetuin-A level is decreasing in post HCV liver cirrhosis and liver cirrhosis with HCC than in healthy control with the lowest level in HCC. Post HCV liver cirrhosis with HCC cases which are not diagnosed by alph-fetoprotein can be captured by Fetuin A and vice versa. Also, the results show no significant correlations of fetuin-A with the CP scores and MELD score in post HCV liver cirrhosis .
Incidence of intradialytic hypertension in hemodialysis patients in Beheira governorate and effect of high flux versus low flux dialysis on it
Authors: Mady Gamal E , El Leil Hisham Atef Abou , Tawfik Ahmed M , Elgendy Ahmed M 
Published: October 2021

Abstract

Background
Intradialytic hypertension (IDH) is a common complication of hemodialysis (HD) that is under-recognized and its significance is underappreciated. No standard definition of IDH exists. As a unifying criteria for the diagnosis of IDH has not been proposed, the focus of this review will be on systolic blood pressure (SBP) rise = 10 mmHg at = 4 over six consecutive sessions. IDH is estimated at 5–15% of HD patients. IDH has been associated with poor clinical outcomes in HD patients including increased hospitalizations, higher ambulatory blood pressure (BP), cardiovascular morbidity, and mortality.

Aim of the Work
To detect the incidence of IDH in HD patients in Beheira governorate and to compare the effect of high flux versus low flux dialysis on it.

Patients and Methods
This study was conducted on 200 patients on maintenance HD from different HD units in Beheira governorate. The patients were divided into two groups: Group 1: 100 patients on HD with high flux dialyzers and Group 2: 100 patients on HD with low flux dialyzers. Results: Incidence of IDH in HD patients in Beheira governorate was 23.5% at the start, 21% after one month and 13% after three months duration. Results of our study demonstrated that there were no significant differences between both groups as regards effect of high-flux vs low-flux dialysis on IDH after one month and at the end of the study (P &gt; 0.05), but there was a significant decrease in number of IDH patients after one month duration and after three months in both high-flux and low-flux dialysis patients. In our study, there was significant improvement in the form of reductions in all of pre-dialysis BUN, post-dialysis BUN, serum creatinine levels and serum IPTH levels at the end of the study in high flux group compared to low flux group. Finally, our results showed significant improvement in serum hemoglobin levels in high flux group by the end of the study in contrast to the low flux group.

Conclusion
No significant difference in the effect of high flux versus low flux dialysis on IDH, but there was significant improvement in all of pre-dialysis BUN, post-dialysis BUN, serum creatinine levels and serum IPTH levels by the end of the study in the high flux group compared to the low flux group.