bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of an Exercise Bout Prior to the Booster Dose of an Inactivated SARS-CoV-2 Vaccine on Immunogenicity in Immunocompromised Patients
Authors: Gualano Bruno , Saad Carla G. S. , Sieczkowska Sofia M. , Lemes Ítalo Ribeiro , Silva Rafael Pires da , Pinto Ana J. , Mazzolani Bruna C. , Smaira Fabiana I. , Gil Saulo , Oliveira-Junior Gersiel , Aikawa Nadia E. , Medeiros-Ribeiro Ana C. , Silva Clovis A. , Yuki Emily F. N. , Pasoto Sandra G , Pereira Rosa M.R. , Shinjo Samuel K. , Andrade Danieli C. O. , Sampaio-Barros Percival D. , Roschel Hamilton , Bonfa Eloisa 
Published: December 2021

Abstract
This study aimed to investigate whether a single bout of exercise prior to the homologous booster dose of a SARS-CoV-2 inactivated vaccine (Sinovac-CoronaVac) could enhance immunogenicity in patients with dysfunctional immune system. This was a randomized controlled trial (1:1) within a single-arm, phase 4 vaccination trial, conducted in São Paulo, Brazil. Patients with spondyloarthritis assigned to the intervention group performed an exercise bout comprising three unilateral strength exercises involving eccentric and concentric contractions. After exercising, patients remained at rest for 1 h prior to vaccination, which was applied to the exercised arm. The control group remained at rest before vaccination. Immunogenicity was assessed before (Pre) and one month after (Post) the booster dose using seropositivity rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), frequency of NAb positivity, and NAb activity. Before the booster dose, 16 patients from the exercise group and 16 patients from the control group exhibited seropositivity for IgG (59% vs. 57.1%), one month after the booster dose, seropositivity occurred in 96% vs. 100% of the cases (p = 0.84, group by time interaction). Only 10 patients from the exercise group and 12 patients from the control group showed positive NAb serology at Pre (37% vs. 42.8%). One month following the booster, NAb positivity was 96% vs. 93% (p = 0.41, group-by-time interaction). GMT was comparable between groups at Pre (p > 0.05). At Post, GMT increased similarly in both groups (exercise: 56.9%; control: 57.9%), with no group-by-time interaction (p = 0.82; estimated mean difference between groups at Post [EMD]: -40.4 UA/mL, 95%CI: -327, 246 UA/mL). Likewise, NAb activity was similar between groups at Pre and increased similarly in both of them as a result of the booster (47.5% vs. 39.9%), with no group-by-time interaction (p = 0.99; EMD: -6.19%, 95%CI: -17; 4.6%). In conclusion, a single bout of exercise did not enhance immunogenicity to a homologous booster dose of an inactivated SARS-CoV-2 vaccine among patients with spondyloarthritis. Studies assessing exercise as an adjuvant to first or second doses remain necessary.
Vital signs of severe COVID-19 patients during inter-hospital helicopter transfer
Authors: Slagt Cornelis , Spoelder Eduard Johannes , Tacken Marijn Cornelia Theresia , Frijlink Maartje , Servaas Sjoerd , Leijte Guus , Eijk Lucas Theodorus , Geffen Geert Jan 
Published: December 2021

Abstract
Background: During the COVID-19 pandemic in The Netherlands, critically ill ventilated COVID-19 patients were not only transferred between hospitals by ambulance, but also by the Helicopter Emergency Medical Service (HEMS). To date, little is known about the impact of helicopter transport on critically ill patients, and COVID-19 patients in particular. This study was conducted to explore the impact of inter-hospital helicopter transfer on vital signs of mechanically ventilated severe COVID-19 intensive care patients, with special focus on take-off, midflight, and landing. Methods: All ventilated critically ill COVID-19 patients who were transported between April 2020 and June 2021 by the Dutch ‘Lifeliner 5’ HEMS team and who were fully monitored including non-invasive cardiac output, were included in this study. Three 10 minute timeframes (take-off, midflight and landing) were defined for analysis. Continuous data of vital parameters heartrate, peripheral oxygen saturation, arterial blood pressure, end-tidal CO2 and non-invasive cardiac output using electrical cardiometry were collected and stored at a 1 minute interval. Data were analysed for differences over time within the timeframes using 1-way analysis of variance. Significant differences were checked for clinical relevance. Results: Ninety-eight patients were included in the analysis. During take-off an increase was noticed in cardiac output (from 6.7 to 8.1 Lmin-1; P<0.0001) which was determined by a decrease in systemic vascular resistance (from 1068 to 750 dyne·s·cm−5, P<0.0001) accompanied by an increase in stroke volume (from 92.0 to 110.2 ml, P<0.0001). Other parameters were unchanged during take-off and mid-flight. During the landing cardiac output and stroke volume slightly decreased (from 7.9 to 7.1 Lmin-1, P<0.0001 and from 108.3 to 100.6 ml, P<0.0001 respectively) and total systemic vascular resistance increased (P<0.0001). Though statistically significant, the found changes were small and not clinically relevant to the medical status of the patients as judged by the attending physicians. Conclusions: Interhospital helicopter transfer of ventilated intensive care patients with COVID-19 can be performed safely and does not result in clinically relevant changes in vital signs. This study this has been assessed by the medical ethical committee Arnhem-Nijmegen, the Netherlands (identifier 2021-7313). The committee waived the need for informed consent. The study was registered at www.trialregister.nl (identifier NL9307).
Comparative inhibition analysis of wild type and G671S catalytic site mutant of the SARS-CoV-2 RNA-dependent RNA polymerase
Authors: Khan Faisal , Basharat Zarrin 
Published: December 2021

Abstract
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has wrecked a global havoc, after its emergence in Wuhan, Hubei province of China. It is known to have a distressing effect on the respiratory tract and has a high mortality rate. Till to date (25 Dec 2021), total number of cases (279,362,428) have been reported across the globe. Variable mutations have been reported on various geographical levels. In this study, we have analyzed G671S mutation of RdRp of the SARS-CoV-2, which has been reported in various strains globally, but importantly delta variant cases of Pakistan and has a serious impact on the protein structure. To study the conformational impact, we screened a Tibetan medicinal compound/Sowa Rigpa library against RdRp and compared the best docked compound (Kaempferol 3-O-gentiobioside) to the wild type and mutant RdRp against Remdesivir. A short simulation was used to validate the findings. Both remdesivir and our screened compound showed better inhibition for mutant, compared to the wild type RdRp.
Full-Scale Field Test On Retaining Structure Enhanced With Soil Nails And Prestressed Anchors
Authors: Wang Hui , Cheng Jian-hua , Guo Yuan-cheng 
Published: December 2021

Abstract
Retaining structure enhanced with soil nails and prestressed anchors is found good at constraining the horizontal displacement and therefore ensuring the stability of the foundation pit during excavation. Based on these advantages, such retaining structure is widely used in foundation excavation practice. This paper presents results of a series of in-situ tests conducted to investigate the mechanical behaviors of retaining structure enhanced with soil nails and prestressed anchors. Behaviors of three different retaining structures enhanced with i) soil-nails; ii) soil-nails and prestressed anchors without unbonded part; iii) soil-nails and prestressed anchors with a 2.5m unbonded length, were monitored during staged excavation to investigate the influences of i) the prestressing force and ii) unbonded length of the prestressed anchors on the performance of the entire retaining system. It was found that the affecting the stress and deformation of composite retaining system, which is in agreement with the other published results in the literature. The variation of the magnitude and distribution of soil nail force responding to the anchor prestressing force however showed no systematic trend. The unbonded length of anchors, which is suggested to be the main factor affecting the structural stability in dense materials in the literature, is found to have little influence in loose fill materials used in this study. Studies presented in this paper are useful for the rational design and serviceability analysis of the composite soil-nailed retaining structure enhanced with prestressed anchors.
Preservation of Data Integrity in Public Cloud Using Enhanced Vigenere Cipher Based Obfuscation
Authors: JAITHUNBI A. K. , SABENA S. , SAIRAMESH L. 
Published: December 2021

Abstract
Today’s internet world is moves to cloud computing to maintain their public data privately in a secure way. In cloud scenario, many security principles are implemented to maintain the secure transmission of data over the internet. And still, the main concern is about maintaining the integrity of our own data in public cloud. Mostly, research works concentrates on cryptographic techniques for secure sharing of data but there is no such mentioned works are available for data integrity. In this paper, a data masking technique called obfuscation is implemented which is used to protect the data from unwanted modification by data breaching attacks. In this work, enhanced Vigenere encryption is used to perform obfuscation that maintains the privacy of the user’s data. Enhanced Vigenere encryption algorithm combined with intelligent rules to maintain the dissimilarity between the data masking for perform encryption with different set of rules. This work mainly concentrates on data privacy with reduced time complexity for encryption and decryption.
Reviewing the Clinical Spectrum Related to Kmt2b Gene Mutations: Unusual Clinical Presentation and a Possible New Pathogenic Mutation
Authors: Toro Cristina del , Romero Jesús Olivares 
Published: December 2021

Abstract
Introduction KMT2B related dystonia is a childhood onset generalized dystonia. Since its first description in 2016, different phenotypic spectrum have been reported. The aim of the case report is to provide data that may help to understand the spectrum of KMT2B-related disorders. We present two members of a family with a possible non-previously described pathogenic mutation and an unusual KMT2B related dystonia presentation: an adult onset and focal dystonia.Case Presentation The index patient is a 32 year-old woman with a generalized dystonia. Her maternal uncle presented a focal dystonia. Next-generation sequencing revealed a heterozygous missense mutation in KMT2B gene (19q13.12), described as a variant of uncertain significance (VUS). Although characteristic phenotype of KMT2B dystonia is a childhood onset generalized dystonia, different phenotypes have been related according to the kinds of mutations in this gene, also varying the age of symptom onset and the penetrance of the mutation. Asymptomatic or sub-clinical carriers and adult onset has been described. Due to the low prevalence of this variant in the general population and the low penetrance and high intrafamilial variability of this entity, we suggest that this mutation might be a pathogenic variant.ConclusionsKMT2B related dystonia is an emerging and prevalent monogenic dystonia whose incidence, genetic variability and clinical spectrum remain unknown. Despite the study of this gene is indicated in childhood onset dystonia, description of cases such as ours shows that its sequencing in patients with an adult-onset dystonia with family history can be useful for the diagnosis.
Evaluation of Metal Contamination, Flux and the Associated Human Health Risk from Atmospheric Dustfall in Metal Mining Areas of Southern Jharkhand, India.
Authors: Mahato Mukesh Kumar , Singh Abhay Kumar , Giri Soma 
Published: December 2021

Abstract
Metals can be apprehended in the atmospheric environment of copper and iron mining areas of Jharkhand, which falls in one of the most mineralised areas of India with extensive mining and industrial activities. The study was taken up to appraise the metal contamination in the atmospheric dust to evaluate the metal fluxes and associated health risk considering the seasonal variations. Sixty samples were analysed for As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn using the inductively coupled plasma mass spectrometer (ICP-MS) and the contamination levels were assessed by various indices. The metal content of dustfall samples exceeded the average shale values for most of the metals. Higher metal concentrations were found in the locations in close vicinity of mining and industrial areas. The principal component analysis suggested both geogenic and anthropogenic sources for metals in the atmospheric dustfall. Human health risk as determined by hazard quotient (HQ) and hazard index (HI) suggested considerable risk to the child populace through the ingestion pathway for both the mining areas, higher being in iron mining areas. The metal flux and the health risk were higher in summers as compared to winters for both the mining areas. Consequently, the results advocate the necessity of periodic monitoring of the freefall dust of the mining areas and development of proper management strategies to reduce the metal pollution.
School-Based Harm Reduction with Adolescents: A Mixed Methods Pilot Study
Authors: Fischer Nina Rose 
Published: December 2021

Abstract
A pilot study of the Safety First: Real Drug Education for Teens curriculum showed significant results pre to post with high school freshmen. Negative outcomes of drug education are linked to failure to engage students because of developmentally inappropriate material or activities are too unrelated to young people to be meaningful. A few harm reduction studies showed significant increase in student's drug related knowledge. Students were less likely to consume substances and less likely to consume to harmful levels. More studies are necessary to evidence harm reduction efficacy in the classroom. The goal of this study was to measure harm reduction knowledge, attitude and behaviors, including drug policy advocacy, before and after Safety First. Data was analyzed using AVOVA, linear regression, t-tests and thematic coding. Survey results, corroborated by the qualitative findings, showed a significant change (p <.05) in high school freshmen knowledge, attitudes and behaviors in relationship to substance use pre to post class. These findings have implications for replication of the curriculum to other sites. Institutional Review Board approval was granted before the study was conducted with human subjects. The file number is 2017-0746. The date of initial registration was June 29 th , 2017, and continued approval has been granted through August 8 th , 2022.
Immediate Effects of Spinal Manipulation on Painful Sensitivity and Postural Stability in Patients with Chronic Nonspecific Low Back Pain: Study Protocol for A Controlled Randomised Clinical Trial.
Authors: FREITAS JOAO PAULO , Corrêa Leticia Amaral , Bittencourt Juliana Valentim , Armstrongd Karine Marcondes , Nogueira Leandro Alberto Calazans 
Published: December 2021

Abstract
Background: Low back pain is one of the main public health concerns. Chronic low back pain (cLBP)reduces functional capacity and affects postural stability.Although health professionals widely use spinal manipulation, its immediate effect on painful sensitivity and postural stability is lacking. This study aims to verify the immediate effects of lumbar spinal manipulation on the pressure pain threshold and postural stability in individuals with cLBP. Methods: A two-arm, placebo-controlled clinical trial with parallel groups and examiner-blinded will be conducted with 80 participants with cLBPfrom an outpatient physical therapy department,randomly allocated at a 1:1 distribution. The experimental group will receive a lumbar spinal manipulation technique, and the placebo group will receive a simulated lumbar spinal manipulation. Both groups will receive one session of treatment and will be evaluated before and immediately after the intervention.The primary outcomes will be the pressure pain threshold and postural stability. Pain intensity and patient´s expectation will be assessed as a secondary outcome. The pressure pain threshold will be assessed using a pressure algometer in 6 different anatomical regions. The evaluation of postural stability will be performed in a baropodometry exam by displacing the centre of pressure. The pain intensity will be measuredusing the Numeric Pain Rating Scale. A Likert scale will be used for the patient´s expectationabout the treatment. A two-way analysis of variance will compare the effect of the interventions between groups. Discussion:This study will provide insights regarding the immediate effects of spinal manipulation in patients with cLBPagainst a simulated spinal manipulation using objective outcomes and considering patients’ expectations regarding the treatment.Trial registration: Brazilian Registry of Clinical Trials:RBR-3ksq2c; registered on 13 July 2020.
Consumption behavior and the lack of financial literacy among teens
Authors: Trisnani Sifa Asri , Adriyani Atika Dian , Wandansari Rifky Aulia , Isthika Wikan 
Published: December 2021

Purpose – The main purpose of this study is to examine role of financial literacy, peer conformity, and hedonic lifestyle towards teenagers’ consumption behavior.Method - Consumer behavior explains the desire to have excessive consumption. The population in this study were all adolescents high school and university in the region of Central Semarang, amounting to 26 583 students, with a sample of 100 adolescents. This study uses a quantitative approach to data collection methods in the form of a questionnaire. The analytical method used is multiple linear regression analysis.Result - Peer conformity, hedonistic lifestyle, and financial literacy simultaneously influence consumer behavior adolescent high school and university in the Middle Semarang with a contribution of 37%. Partially significance value 0769 for peer conformity and 0. 992 for financial literacy while lifestyle 0:00 hedonic significance value. In this study, only hedonic factors that influence consumer behavior of teenagers.Implication - This study can be used to understand behavior in teenager, especially in terms of purchase and consumption behavior.Originaility - This research examine financial literacy in teenager phase.
Role of Grab on the social life changes of Bengkulu City
Authors: Widanti Afrima , Rahmayanti Dewi 
Published: December 2021

Purpose – The presence of Grab has invited many discussions. The purpose of this study is to know the role of Grab on changes in social life in Bengkulu city both in terms of Grab drivers, consumers, and other conventional transportation.Method – This study uses a qualitative approach with an in-depth interview method. The total respondents in this study are 38 people consisting of 5 people from Grab drivers, 30 people from consumers, and five people from conventional transportation.Result – This study found that there were changes in Grab drivers' income, but there were no social changes in Grab drivers. On the other hand, there were social changes in Grab consumers and conventional drivers. Implication – This study can be used by public, government, and private sector to understand better consumer behaviour in online transportation field.Originality – As the growth of online transportation in Indonesia is increasing, this study offers early understanding upon the phenomena.
INVESTIGATION OF THE EFFECT OF COVID-19 OUTBREAK ON PHYSICAL ACTIVITY, PERCEIVED STRESS, PHYSICAL ACTIVITY AWARENESS AND EXERCISE BARRIERS: A NATIONAL STUDY
Authors: AKÇAY Burçin , YILMAZ GÖKMEN Gülhan , KEÇELİOĞLU Şule , KESKİN Esra , TÜRKMEN Ozan 
Published: December 2021

Purpose: The aim of this study was to investigate the effect of COVID-19 on physical activity, perceived stress, awareness of physical activity, and exercise barriers nationally.
Methods: The survey was sent on-line and data were collected from 1087 volunteers between May 8 and May 31, 2020. The physical activity levels of the respondents were evaluated with the Physical Activity (PA) Questionnaire-Short Form and stress levels with the Perceived Stress Scale. The awareness of exercise and barriers to exercise were questioned with qualitative questions. One-way ANOVA, the Chi-squared test, and Pearson Correlation analysis were used to evaluate the data.
Results: During the COVID-19, 70% of adults had inadequate PA. It was observed that the stress level was different in terms of PA levels (p
The Significant Role of Nutraceutical Compounds in Ulcerative Colitis
Treatment
Authors: Maio Azzurra Chiara De , Basile Giovanna , Iacopetta Domenico , Catalano Alessia , Ceramella Jessica , Cafaro Danilo , Saturnino Carmela , Sinicropi Maria Stefania 
Published: December 2021

Abstract:
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) mainly
affecting the colon and the rectum. Its main characteristics include relapsing and remitting
mucosal inflammation, starting in the rectum and typically extending continuously
proximally through part of or the entire colon. UC pathogenesis depends on multiple factors,
such as genetic predisposition, defects in the epithelial barrier, dysregulated immune
responses, and environmental causes. The most frequent symptoms are abdominal pain,
weight loss, mucus discharge, bloody diarrhoea, incontinence, nocturnal defecations, fever,
and anemia. Existing therapies for UC include 5-aminosalicylic acid (5-ASA) and its
derivatives, steroids, immunosuppressants, and biological drugs. However, limited efficacy
and unwanted adverse effects hardly limit these strategies of treatment. In the last decades,
research studies have been driven towards complementary and alternative
medicines for the treatment of UC. Various nutraceuticals have exhibited promising results
in modulating intestinal inflammation while improving symptoms. These compounds
possess a wide spectrum of positive health effects evidenced by in vitro studies,
characterized by their involvement in antioxidant defenses, cell proliferation, and gene
expression. The present review analyzes the available data about the different types of nutraceuticals
and their potential effectiveness as adjuvant therapy of IBD, with particular
emphasis to UC.
Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges
Authors: Rahman Lutfur , Asif Sabahat , Ullah Ata , Khan Waheed S. , Rehman Asma 
Published: December 2021

Abstract:
The rapid emergence of multidrug-resistant bacterial strains highlights the need for the
development of new antimicrobial compounds/materials to address associated healthcare challenges.
Meanwhile, the adverse side effects of conventional antibiotics on human health urge the
development of new natural product-based antimicrobials to minimize the side effects. In this respect,
we concisely review the recent scientific contributions to develop natural product-based
nano-antibiotics. The focus of the review is on the use of flavonoids, peptides, and cationic biopolymer
functionalized metal/metal oxide nanoparticles as efficient tools to hit the MDR bacterial
strains. It summarizes the most recent aspects of the functionalized nanoparticles against various
pathogenic bacterial strains for their minimal inhibitory concentrations and mechanism of action at
the cellular and molecular levels. In the end, the future perspectives to materialize the in vivo applications
of nano-antimicrobials are suggested based on the available research.