bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of spontaneous tumor regression on melanoma progression
Authors: Titov K. S. , Sorokina M. V. , Paklina O. V. , Kiselevskiy M. V. , Lebedev S. S. , Lunina A. V. 
Published: December 2024

Background. Skin melanoma (SM) is a malignant non-epithelial tumor of transformed melanocytes with predominant localization on the skin (more than 90 % of cases). According to statistics for 2021, SM in Russia accounted for 1.82 % of all malignant neoplasms of the adult population and 12.65 % of all skin tumors. There has been a steady and annual increase in the incidence of SM throughout the world, especially in countries with a predominantly Caucasian population. In Russia, over the past 10 years, mortality from SM has increased by 17.6 %. SM is a heterogeneous tumor with a high metastatic potential, because in addition to standard clinical and pathomorphological prognostic factors, the identification of additional factors of progression and unfavorable prognosis of the disease remains an urgent and unresolved problem of modern oncology.Aim. To determine the role of spontaneous tumor regression in the occurrence of SM progression based on the analysis of literature data and their systematization.Results. This literature review reflects various global research data on the role of spontaneous regression of SM in progression. Spontaneous regression of SM is an immunological process in which the disappearance of tumor cells is observed, which leads to the division of the tumor into separate islands with intermediate areas of non-tumor tissue. The mechanism of spontaneous regression of primary SM, as well as its prognostic significance, is not well understood and studied. Of course, most researchers primarily associate the occurrence of spontaneous regression of melanoma with an immune response, since lymphocytic infiltration of the tumor was noted in all cases of regression. The presence of lymphoid infiltration, as well as the quantitative and qualitative ratio of its cells, are important in the development of the tumor process, affect the effectiveness of immunotherapy and is to a greater extent a factor in a favorable prognosis.Conclusion. The prognostic role of spontaneous melanoma regression is still an unresolved and controversial issue. Interestingly, a number of studies demonstrate that regression is an independent predictor of the progression of SM.
FCGR3A (CD16A) and FCGR3B (CD16B) mRNA levels in the blood of prostate cancer patients
Authors: Novikov D. V. , Arioua Kh. M. , Korovin O. A. , Kalugin A. V. , Shumilova S. V. , Alyasova A. V. , Hamidani L. , Novikov V. V. 
Published: December 2024

Background. FCGR3A and FCGR3B messengers RNA (mRNA) translate the synthesis of membrane molecules of CD16A and CD16B, which are low-affinity immunoglobulin (Ig) G receptors bound to different cells of the immune system and involved in the immune response to tumors.Aim. The aim of this study was to determine the level of FCGR3A and FCGR3B mRNA in the peripheral blood of patients with prostate cancer (PC).Materials and methods. Blood samples from 47 prostate cancer patients and 31 healthy blood donors were examined. The relative level of FCGR3A and FCGR3B mRNA in the blood of patients and healthy donors was determined by reverse transcription polymerase chain reaction in real time (real-time RT-PCR).Results. It has been shown that the relative level of FCGR3A and FCGR3B mRNA in the blood of PC patients exceeds the level evaluated in volunteers. The relative level of FCGR3A mRNA increases with age, with an increase in PSA concentration, prostate volume and stiffness, and in the presence of metastases. Differences in testosterone concentration, Gleason score, disease stage and tumor spread were not accompanied by changes in FCGR3A mRNA level. For FCGR3B mRNA, a different manner of its changes was revealed. As PSA concentration and prostate tissue stiffness increased, elevated FCGR3B mRNA level decreased, reaching normal levels. In the absence of metastases, it was higher than if they were present. In addition, trends towards an increase in the level of FCGR3B mRNA were revealed with an increase in the stage of the disease, the concentration of testosterone to 7 mmol / L and above, as well as the Gleason score to 7 and above.Conclusion. Multidirectional changes in FCGR3A and FCGR3B mRNA levels were found with an increase in the severity of PC. Probably, the revealed nature of the change in the level of FCGR3A and FCGR3B mRNA associated with the dose-dependent effect of PSA on their level. The results indicate a possible monitoring value of FCGR3A mRNA and FCGR3B mRNA levels in the blood of PC patients.
Comparative pharmacokinetics of pembrolizumab after single intravenous administration to Macaca fascicularis
Authors: Kosman V. M. , Karlina M. V. , Barybina T. N. , Faustova N. M. , Matichin A. A. , Makarov V. G. , Makarova M. N. , Dmitrieva A. A. , Shipaeva E. V. , Podolyakina A. I. , Filon O. V. , Samsonov M. Yu. , Ignatiev V. G. 
Published: December 2024

Background. Pembrolizumab belongs to a fundamentally new class of antitumor agents with biological source – monoclonal antibodies. when creating generic biological medicinal products, it is necessary to assess the comparability of the pharmacokinetics of the developed drug and the original (reference) drug product in relevant animal species.Aim. To compare the pharmacokinetics of two drugs with INN pembrolizumab, concentrate for solution for infusion, administered once intravenously to Macaca fascicularis.Materials and methods. Biosimilar RPH-075 (INN pembrolizumab, JSC R-Pharm, Russia) and reference drug Keytruda® (INN pembrolizumab, MSD International GmbH) were administered once intravenously to male monkeys (2 groups of 4 males each) at a dose of 30 mg/kg. Macaque blood samples were collected for analysis before administration and at 1, 2, 4, 8, 24, 48, 72, 144, 312, 480, 648, 984, 1320 h after administration. Plasma concentrations of the active ingredient were determined by bridging ELISA using commercially available antibodies, followed by calculation of the main pharmacokinetic parameters (Cmax, AUC, MRT, Vss, T1/2, Cl).Results. Using antibodies more available than commercial reagent kits, the pembrolizumab assay method recommended by the antibody manufacturer has been replicated. The method has been validated and applied to the analysis of biosamples obtained in the preclinical study. There was no effect of the test drug and the reference drug upon single intravenous administration to monkeys condition and animals body weigh; drugs were found to have comparable pharmacokinetic profiles.Conclusion. The creation of a biosimilar drug in the Russian Federation will improve the treatment of patients with cancer, reduce the cost of treatment and increase the number of patients receiving high-quality medical care.
Experimental study of somatostatin analogue cyphetrylin lipophilicity
Authors: Shprakh Z. S. , Ignateva E. V. , Kraeva M. N. , Yartseva I. V. , Gusev D. V. , Dmitrieva M. V. 
Published: December 2024

Background. Lipophilicity is a fundamental physicochemical property that determines the solubility and transport of a drug through biological membranes, as well as its behavior in the body. Lipophilicity also affects the ability of a drug to bind to plasma proteins and reach the corresponding receptors. The standard for drug lipophilicity experimental study is measuring the distribution between two immiscible phases – aqueous (water and buffer solutions) and hydrophobic (most often octanol).Aim. The experimental study of somatostatin analogue cyphetrylin lipophilicity in octanol/water system distribution test.Materials and methods. The lipophilicity of cyphetrylin, synthesized in the Laboratory of Chemical Synthesis of the N.N. Blokhin National Medical Research Center for Oncology of the Russian Ministry of Health, was studied in the octanol/water system; ethanol was used to study cyphetrylin spectral characteristics and its quantitative determination; shake flask method, UV-spectrometry.Results. The experimental assessment of cyphetrylin lipophilicity was carried out by shake flask method in a system of mutually saturated water and octanol 1:1. Since cyphetrylin is practically insoluble in water, the concentration of the drug in the octanol phase was determined by UV-spectrometry and the concentration in water was calculated by mass balance. Lipophilicity was expressed as the decimal logarithm of the concentration of cyphetrylin in the octanol phase to its concentration in the aqueous phase (logPo/w) ratio. The experimentally determined value of logPo/w was 1.14.Conclusion. The lipophilicity of cyphetrylin was studied experimentally by shake flask method as a parameter that determines the molecule probability to reach the biological target. The logPo/w value 1.14 in decimal logarithmic form indicates moderate lipophilicity of cyphetrylin, which exhibits antitumor activity when interacting with somatostatin receptors.
Comparing the curriculum and academic structure of the Iraqi college of dentistry with Arab Universities, and conducting satisfaction surveys among Iraqi dentistry students and alumni
Authors: Aljazaeri Sundus Abdull Wadood , Radhi Reham Adnan , Abbas Husain lafta , Hafidh Abd Alzahra Abbas , Abdulnabi Abbas Dawood , Raheem Abdullah Ayoub , Saiwan Ahmed Abdulmotleb 
Published: December 2024

The Iraqi dental education program follows a standardized curriculum derived from the original College of Dentistry in Baghdad, which has undergone some recent revisions. to determine the effectiveness of the Iraqi dental education program, identify areas for improvement, compare the program to an Arabic university and assess the satisfaction of graduates. : A comparative analysis was conducted at the College of Dentistry at the University of Basra in the academic year 2022-2023 between the curriculum of Basrah dental curriculum and that of four Arab dental colleges, involving 466 graduates and students from Iraqi dental colleges. Iraq's College of Dentistry follows an annual study system with a unified curriculum, which differs from Arab colleges; that follow the semester study system; in terms of basic sciences, pre-clinical dental subjects, clinical subjects, and clinical dental curricula. In contrast, basic sciences are taught in a preparatory year before studying in three Arab colleges, while basic medical sciences are taught in the first three years in all colleges except Iraq. A study of students and practising dentists from 466 dental colleges in Iraq found that the College of Dentistry was not the right place for students to study the first level of basic science. The program failed to effectively prepare students for the workplace.Dental colleges need to change to the semester system instead of the annual one. The curricula need to be reviewed intensively in terms of the types of curricula and their distribution to the stages. Introducing a preparatory year for basic sciences before studying in dental colleges. Limiting the medical sciences in the first and second years. The third year is concentrated on preclinical for all dental subjects and the fourth and fifth years include all clinical dentistry with the addition of curricula such as research methodology, artificial intelligence approaches, medical ethics, patient rights and effective communication that can help dentistry colleges graduate students with well-rounded skills.
Myxoglobulosis in mucocele of oral cavity – A rare entity
Authors: Baskaran Birundha , Danassegarane Senthilkumaran , Sandirakesan Kalaiarasan , Shambavi Jeya , Kaliyamoorthy Siva 
Published: December 2024

Myxoglobulosis, a variant of mucocele,was first coined by Von Hansemann in 1914. The mucin globules were formed as an attempt to organise the mucin by the surrounding granulation tissue.A 17 years old male patient came with the history of swelling over the lower lip for past 2 months. Swelling measured about 2x2 cm, fluctuating, soft in consistency. Histopathological examination revealed features of mucocele with globules forming myxoglobulosis.Prognosis of mucocele – myxoglobulosis variant will be better than other types of mucoceles with low recurrence rate, good host response, however follow-up is essential.
Rola grupy G6 w polityce bezpieczeństwa wewnętrznego Unii Europejskiej
Authors: Gruszczak Artur 
Published: December 2024

Niniejszy artykuł ma na celu przeanalizowanie wpływu grupy G6 na obszar bezpieczeństwa wewnętrznego Unii Europejskiej. G6 jest przykładem inicjatyw, które powstały poza prawno-instytucjonalnymi ramami Unii Europejskiej, ale miały na celu wywarcie znaczącego wpływu na procesy polityczne w UE. Pytanie badawcze postawione w tym artykule brzmi: Jaki wpływ miała agenda G6 na kształtowanie polityki w zakresie bezpieczeństwa wewnętrznego UE? Metodologia obejmuje postfunkcjonalizm jako ramę teoretyczną. Badania opierały się na metodach jakościowych, analizie źródeł pierwotnych i literatury przedmiotu. Wyniki badań wskazują na znaczący wpływ G6 jako nieformalnego forum konsultacji i ustalania agendy w odniesieniu do istotnych kwestii bezpieczeństwa wewnętrznego UE. G6 wspierała politykę UE w sytuacji najpoważniejszych wyzwań bezpieczeństwa, korzystając z konstruktywnego kompromisu między ponadnarodowymi skutkami polityki UE a interesami państw członkowskich.
Ogromne kazni in veliko novih obveznosti glede uvedbe direktive NIS2
Authors: DE MARGAN FLORIAN 
Published: December 2024

Na tisoč slovenskih podjetij, občin, bolnic, državnih ustanov, čaka kmalu najnovejša kibernetična obveznost imenovana NIS2 (varnost omrežij in informacija ali Network and Information Security). Široko prediskutovana evropska smernica ima za cilj nekompromisno posilit kibernetično varnost podjetjem in državnim organom – ustanov v EU kot celote. Stroške, ki ne bodo majhni bodo morale plačati sama podjetja oziroma državne ustanove s potrebnimi tehničnimi, operativnimi in organizacijskimi ukrepi, ki jih bo zahtevala izvedba odloka oziroma navedena smernica.
Effect of Foliar Application of Chemical Nutrient Mixture and Growth Regulators on Different Leaf Parameters of Pot-Anthuriums
Authors: Sahu Subhasmita , Palai Siddharth Kumar , Tripathy Pradyumna , Panda Narayan , Jena Lopamudra , Pradhan Pranaya , Samantaray Banani Priyadarshini 
Published: December 2024

Background: Leaves are vital plant organs executing major physiological functions of plants. They act as a primary site for carbohydrate synthesis and transpiration. The leaf characteristics also readily affect the flowering. Chlorophyll in the leaves plays major role in photosynthesis. In pot plant industry, the size, shape and colour hold the commercial value. An experiment was carried out on tropical flowering Anthuriums for pot plant production in coastal Bhubaneswar area under AICRP floriculture to study effect of different nutrients and growth regulators/bio-stimulants on pot- Anthuriums leaves. Methods: The treatments include five types of nutrient solution sprayed with varying frequency of weekly once and twice and six types of growth regulators with varying forms and concentrations. Significant variation was observed in different leaf parameters obtained from different treatment combinations. Result: Among all the nutrient treatments, liquid MS medium resulted better leaf characteristics with once week spray and among different growth regulators, GA3 @ 200 ppm resulted better leaf characteristics. Among the treatments, spraying of liquid MS medium once in week resulted in highest leaf breadth (1.93 cm), leaf area (8.20 cm2) and leaf chlorophyll content (0.87 mg/ cm2). Spraying liquid MS medium once in a week along with GA3 @ 200ppm sprayed at two months interval resulted in largest leaf area (12.42 cm2).
MENINGKATKAN KECERDASAN INTERPERSONAL ANAK USIA DINI MELALUI KEGIATAN BERMAIN PERAN
Authors: Rizqi Ilahi Zaitun Nur , Elvira Melly 
Published: December 2024

Interpersonal intelligence has an important role in children's social development. Children who have good interpersonal intelligence will easily adapt to new environments. This research aims to determine the increase in interpersonal intelligence of children aged 5-6 years through role playing activities. This research uses a quantitative approach of the Quasi Experiment type with an equivalent time series design. The sample in this study was the B2 group of Almaarif Singosari Islamic Kindergarten, totaling 16 children. The data collection technique used is observation and documentation, while the data analysis technique uses the Friedman Test. Based on the research results, data analysis carried out using the Friedman test showed that the p value was <.001, which means there was a significant difference in each posttest carried out. The results of the Friedman test calculation show that the p value (<.001) <0.05 means Ha is accepted and Ho is rejected. Therefore, it can be concluded that role playing activities can improve interpersonal intelligence in children aged 5-6 years at Al Maarif Singosari Islamic Kindergarten.
Keywords: Interpersonal Intelligence; Role Playing
ABSTRAK
Kecerdasan interpersonal memiliki peranan penting bagi perkembangan sosial anak. Anak yang memiliki kecerdasan interpersonal yang baik akan mudah beradaptasi dengan lingkungan baru. Penelitian ini bertujuan untuk mengetahui peningkatan kecerdasan interpersonal anak usia 5-6 tahun melalui kegiatan bermain peran. Penelitian ini menggunakan pendekatan kuantitatif jenis Quasi Eksperiment dengan equivalent time series design. Sampel pada penelitian ini adalah kelompok B2 TK Islam Almaarif Singosari yang berjumlah 16 anak. Teknik Pengumpulan data yang digunakan berupa observasi dan dokumentasi, sedangkan teknik analisis data menggunakan Uji Friedman. Berdasarkan hasil penelitian, analisis data yang dilakukan menggunakan uji friedman diperoleh bahwa nilai p sebesar <.001 yang artinya terdapat perbedaan yang signifikan pada setiap posttest yang dilakukan. Hasil perhitungan uji friedman tersebut menunjukkan bahwa nilai p (<.001) < 0,05 maka Ha diterima dan Ho ditolak. Oleh karena itu, dapat disimpulkan bahwa kegiatan bermain peran dapat meningkatkan kecerdasan interpersonal pada anak usia 5-6 tahun di TK Islam Al maarif singosari.
Kata-Kata Kunci: Kecerdasan Interpersonal; Bermain Peran
STRATEGI PENGEMBANGAN MASJID BAGI GENEARSI MUDA MELALUI PERSATUAN BULUTANGIS
Authors: Yusuf Milin Ari Yunaldi 
Published: December 2024

Abstract
Youths and teenagers in Islam represent the future generation of the Muslim community, starting from the enrichment of mosques to involvement in Islamic organizations. With the presence of Islamic youths and teenagers in Gang Slamet, Bina Karya Hamlet, Rasau Jaya Satu Village, there are numerous activities that can be undertaken to enrich the mosques, especially during Islamic celebrations such as the Prophet's Birthday, Isra' Mi'raj, Takbir parades on Eid al-Fitr and Eid al-Adha, and during the month of Muharram, among others. There are various ways for youths and teenagers to participate in these Islamic celebrations, such as encouraging them to join badminton training and engage in sports activities within the Badminton Committee established by Nurul Hidayah Badminton Committee (PBND). This enables youths and teenagers to foster camaraderie and mutual support among themselves, regardless of age.

Abstrak
Pemuda dan remaja Islam adalah generasi penurus bagi umat Islam kedepannya, mulai dari memakmurkan masjid dan mengikuti organisasi Islam. Dengan adanya pemuda dan remaja Islam, di Gang Slamet Dusun Bina Karya Desa Rasau Jaya Satu banyak sekali yang bisa dilakukan dalam memakmurkan masjid, yakni di Hari Besar Islam, baik diacara Maulid Nabi, Isro’ Mi’raj, Takbir Keliling hari Raya Idul Fitri dan Raya Idul Adha, Muharrom dll. Banyak cara untuk pemuda dan remaja agar bisa mengikuti hari besar Islam yang dilaksanakan, dengan memancing pemuda dan remaja untuk mengikuti Pelatihan Badminton dan saling mensport dalam Pengurus Bulutangkis yang didirikan oleh Pengurus Bulutangkis Nurul Hidayah (PBND). Sehingga pemuda dan remaja bisa saling silaturrahmi dan saling mengayomi dengan sesama, baik itu tua maupun muda.
PENGARUH BERMAIN KOLASE TERHADAP KEMAMPUAN MOTORIK ANAK SEKOLAH DASAR PADA KONSEP LINGKUNGAN SEHAT
Authors: Abdurrahim Abdurrahim , Fahmi Fahmi 
Published: December 2024

Masalah dalam penelitian ini adalah rendahnya kemampuan motorik pada anak usia 6 tahun di SDN Kuin Selatan 6. Penelitian ini bertujuan untuk mengetahui pengaruh kegiatan bermain kolase terhadap kemampuan motorik anak. Metode penelitian yang digunakan adalah pre-eksperimental dengan desain one group prestest-posttest. Teknik pengambilan sampel menggunakan sampel jenuh. Teknik pengumpulan data yang digunakan adalah teknik observasi. Hasil penelitian menunjukkan adanya pengaruh antara kegiatan bermain kolase terhadap kemampuan motorik anak. Dibuktikan dengan adanya peningkatan kemampuan motorik anak SDN Kuin Selatan 6.Kata kunci: Sekolah dasar, bermain kolase, kemampuan motorik. The problem in this study is the low motor skills of 6-year-old children at SDN Kuin Selatan 6. This study aims to determine the effect of collage playing activities on children's motor skills. The research method used is pre-experimental with a one group pretest-posttest design. The sampling technique uses saturated samples. The data collection technique used is the observation technique. The results of the study showed an effect between collage playing activities on children's motor skills. Evidenced by an increase in the motor skills of children at SDN Kuin Selatan 6.Keywords: Elementary school, collage play, motor skills.
Pengaruh Tingkat Kesejahteraan Keluarga Terhadap Prestasi Belajar Siswa Pada Mata Pelajaran Sosiologi di SMAN 19 Kabupaten Tangerang
Authors: Bachtiar Janu Shyam , Kuntari Septi , Irfani Lindawati Yustika 
Published: December 2024

The focus of this research is student learning achievement which is caused by the level of family welfare. The aims of this research are 1) To find out whether there is an influence of the level of family welfare on student learning achievement in sociology subjects at SMAN 19 Tangerang Regency, 2) To find out how much influence the level of family welfare has on student learning achievement in sociology subjects at SMAN 19 Tangerang Regency. Data collection techniques use questionnaries, interviews and documentation. The sampling technique used was purposive sampling technique, in this study the samples chosen were 2 (two) classes, namely XI IPS 3 and XI IPS 4 for the 2022/2023 academic years. The results of research showed that 1) Based on linear regression analysis show that the regression equation is Ŷ = 90,671 – 0,027X, so that an r2 value of 0,005 or 0,5% is obtained. This shows that there is a negative and insignificant influence on the level of family welfare on student learning achievement in sociology subjects at SMAN 19 Kabupaten Regency it was 0,5%. 2) Based on the analysis of the stages of a prosperous family according to the BKKBN the respondents is in the prosperous family category 3, 3) Based on the analysis of learning achievement the respondents is in the high achievement category, In the end, analysis of Maslow’s hierarchy of needs theory, students go to school to feel secure about their future and students go to school to get good achievements so as to improve their social status.