bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Comeback of the IUD in Twenty-First Century USA
Authors: Watkins Elizabeth Siegel 
Published: February 2021

Abstract
From 1995 to 2014, intrauterine devices (IUDs) rose from ranking 10th (out of 11) among contraceptive methods to being the fourth most popular, outnumbered only by the pill, sterilization, and condoms. In 1995, the IUD had been largely abandoned by American doctors; two decades later, major medical associations promoted it as a “first line” method for prospective users of all ages. This paper explains the rapid and dramatic increase in intrauterine contraception by exploring three influential factors from the 1970s-1980s – the Dalkon Shield disaster, the lack of innovation in contraceptive research and development, and the moral panic over teen pregnancy in America – that created circumstances by the early 2000s in which health care providers became more receptive to long-acting reversible contraception. Key thought leaders in obstetrics and gynecology took it upon themselves to rehabilitate the IUD in the court of medical opinion and succeeded in securing professional approval of the device as the initial step in its resurrection.
Current Distribution and Population Persistence of Five Lepidopteran Pests in U.S. Soybean
Authors: Huseth Anders S , Koch Robert L , Reisig Dominic , Davis Jeffrey A , Paula-Moraes Silvana V , Hodgson Erin W 
Published: February 2021

AbstractThe distribution of lepidopteran pests in soybean (Glycine max (L.) Merr.) is a current knowledge gap limiting accurate prioritization of Integrated Pest Management (IPM) research. Regional characterizations of lepidopteran distribution in soybean are now more than 25 yr old. The goal of this study was to generate a contemporary assessment of the distribution and population persistence of lepidopteran soybean pests. To understand which species are currently infesting soybean and their persistence, we conducted a survey of soybean entomologists with responsibility for approximately 33.6 million hectares of production in 31 U.S. states. Soybean entomologists were asked questions about presence of lepidopteran pests and their persistence in their state. We focused this survey on five lepidopteran pests: corn earworm (Helicoverpa zea Boddie) (Lepidoptera: Noctuidae), green cloverworm (Hypena scabra Fabricius) (Lepidoptera: Erebidae), painted lady (Vanessa cardui L.) (Lepidoptera: Nymphalidae), soybean looper (Chrysodeixis includens Walker) (Lepidoptera: Noctuidae), and velvetbean caterpillar (Anticarsia gemmatalis Hübner) (Lepidoptera: Erebidae). Soybean entomologists also provided insight into regionally relevant or sporadic lepidopteran soybean pests. Participants were also questioned about common scouting practices in each state. Results of this survey highlight dissimilar geographic distribution and relative persistence of lepidopteran pests in soybean. Clear differences in occurrence and abundance among species provide important contemporary distributions and persistence estimates. Assessments of scouting practices demonstrate a need to improve IPM adoption in some states. Results of this study and its complementary pest profile (concurrently published in JIPM) provide a contemporary foundation for studies of lepidopteran soybean pests.
Immunotherapy for sarcomas
Authors: Nakata Eiji , Fujiwara Tomohiro , Kunisada Toshiyuki , Ito Tastuo , Takihira Shota , Ozaki Toshifumi 
Published: February 2021

AbstractSarcomas are a heterogeneous group of malignancies of mesenchymal origin; their molecular and genomic mechanisms differ with regard to histology. These characteristics lead to the presentation of varied immunological profiles based on the tumor microenvironment. Various immunotherapies are considered for the treatment of sarcoma. These treatments are performed either in isolation or in combination with other methods such as cytotoxic chemotherapy or the use of molecular target agents. Among these, two recently emerging immunotherapies include T-cell receptor gene therapy and immune checkpoint inhibitor therapy, which are expected to be effective for many types of sarcoma. A sarcoma with a disease-specific translocation and a limited number of mutations, such as synovial sarcoma, expresses high levels of self-antigens, like the New York esophageal squamous cell carcinoma 1, which has been targeted in T-cell receptor gene therapy. On the other hand, sarcomas with a greater number of mutations, such as undifferentiated pleomorphic sarcomas, myxofibrosarcoma and dedifferentiated liposarcomas, can be good candidates for immune checkpoint inhibitors. Among immune checkpoint inhibitor therapies, programmed cell death-1 blockade (nivolumab and pembrolizumab) and cytotoxic T-lymphocyte–associated antigen 4 blockade (ipilimumab) have been investigated most often in sarcoma. Although the sole use of immune checkpoint inhibitors provides limited efficacy, combined immunotherapy with immune checkpoint inhibitors or molecular target agents, especially antiangiogenic agents, has shown moderate results against some types of sarcoma, such as the alveolar soft part sarcoma. Several clinical trials utilizing immunotherapy, including T-cell receptor gene therapy and immune checkpoint inhibitors, in sarcomas are under progress. By clarifying the tumor microenvironment and biomarker-predictive capacity of immunotherapy in sarcomas, better clinical trials can be designed; this could lead to improved outcomes for immunotherapy in sarcoma.
Adverse Events and Perception of Benefit From Duloxetine for Treating Aromatase Inhibitor-Associated Arthralgias
Authors: Schnell Patrick M , Lustberg Maryam B , Henry N Lynn 
Published: February 2021

Abstract

Background
Duloxetine effectively treats aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) in women with breast cancer but causes low-grade toxicities. This secondary analysis examines the relationship between adverse events (AE) and patient-perceived benefit, based on patient self-report that the treatment received was beneficial despite side effects. We hypothesized that duloxetine had a favorable effect on patient-perceived benefit, even among duloxetine-treated patients who experienced AEs and who, had they been treated with placebo, would have experienced none.

Methods
Principal stratification was used to estimate the effect of duloxetine vs placebo on patient-perceived benefit and Functional Assessment of Cancer Therapy-Endocrine Scale functional quality of life in the randomized, double-blind trial SWOG S1202 (n = 289). Subgroups of patients were defined by observed and counterfactual (what would have occurred had they been randomly assigned to the opposite study arm) experiences of AEs and the original primary outcome, reduction of average pain after 12 weeks of at least 2 points on the Brief Pain Inventory-Short Form.

Results
Duloxetine caused an estimated 23.4% (95% credible interval [CI] = 13.4% to 33.7%) of patients to experience an AE even though they would have experienced none on placebo. Those patients remained more likely to report that their received treatment was beneficial than comparable patients assigned placebo (73.3% vs 41.8%, respectively; 95% CI for difference = 15.4 to 47.2 percentage points), although there was no statistically significant effect of duloxetine on functional quality of life (11.3 vs 9.0, 95% CI for difference = -2.2 to +6.7).

Conclusion
Duloxetine resulted in higher patient-perceived benefit, even among those who would have an AE on duloxetine but none on placebo. Treatment of AIMSS with duloxetine should be considered for appropriate patients.
Theoretical study on dynamic responses of an unlined circular tunnel subjected to blasting P-waves
Authors: Lu Shiwei , Zhou Chuanbo , Zhang Zhen , Ji Ling , Jiang Nan 
Published: February 2021

Abstract
In conventional studies, the blasting seismic wave is always treated as a time-harmonic wave, which is not suitable in some situations due to its short duration. In this paper, the blasting P-wave is simplified as a triangular impulse. The distribution functions of dynamic stress concentration factor (DSCF) and the radial and hoop vibration velocity scaling factors (RVSF and HVSF) around the circular tunnel are derived based on the Fourier–Bessel expansion method. Then, the effects of the rising duration, the total duration and Poisson's ratio on DSCF, RVSF and HVSF are discussed. Results show that (1) the maximum RVSF and HVSF are located at the incident side, and the location of the maximum DSCF will move from the incident side to the shadow side when the total duration increases; (2) the maximum DSCF increases with the increasing total duration, decreases with the increasing Poisson's ratio, but is immune to the ratio of the rising to total duration; (3) the maximum RVSF decreases with the increase of the total duration and the ratio of the rising to total duration, but increases with the increasing Poisson's ratio; (4) the maximum HVSF decreases with the increase of the total duration and the ratio of the rising to total duration, but is immune to Poisson's ratio; (5) the RVSF and HVSF under triangular impulses gradually change from less than those under time-harmonic waves to greater than those under time-harmonic waves with the increasing total duration, but the DSCF shows the opposite trend.
Effect of total glucosides of paeony and Tripterygium wilfordii polyglycosides on erythrocyte methotrexate polyglutamates in rats, analysed using ultra-high-performance liquid chromatography-tandem mass spectrometry
Authors: Wu Shulong , Mo Liqian , Ye Chunxiao , Xun Tianrong , Wang Xiaokang , Lv Bin , Zhan Xia , Liu Bin , Ding Qing , Peng Jun , Chen Congyan , Yang Xixiao 
Published: February 2021

Abstract

Objectives
The aim of the study was to explore the effect of total glucosides of paeony (TGP) and Tripterygium wilfordii polyglycosides (TWP) on erythrocyte methotrexate polyglutamates (MTXPGs), the metabolites of methotrexate (MTX).

Methods
An ultra-high-performance liquid chromatography (UPLC)-tandem mass spectrometry (MS/MS) method was developed to determine MTXPGs. The effects of MTXPGs were analysed using 24 male Sprague-Dawley rats that were randomly divided into the MTX alone, MTX-TGP combined, and MTX-TWP combined groups. Rats were administered MTX at a dose of 0.9 mg/kg once a week, TGP at 0.054 g/kg and TWP at 1.8 mg/kg three times a day. Venous blood (1.0 ml) was collected at weeks 2, 4, 6, 9, 12 and 15 and then analysed using the developed UPLC-MS/MS method.

Key findings
Specificity, linear range, inter-and intra-day precision, recovery, matrix effect and stability of MTXPGs met the standard regulations. This method was successfully used for the detection of MTXPGs. After administration of MTX alone, erythrocyte MTXPGs increased and accumulated in a time- and dose-dependent manner. Compared to MTX alone, the combination with TGP significantly decreased the content of total MTXPGs and short-chain MTXPGs (Methotrexate [MTX/MTXPG1] and 4-amino-10-methylpteroyldiglutamic acid [MTXPG2], P &lt; 0.05), but had no significant effect on long-chain MTXPGs (4-amino-10-methylpteroyltriglutamic acid [MTXPG3], P &gt; 0.05) and very long-chain MTXPGs (4-amino-10-methylpteroyltetraglutamic acid [MTXPG4] and 4-amino-10-methylpteroylpentaglutamic acid [MTXPG5], P &gt; 0.05) at week 15. The combination of MTX with TWP had no significant effect on the content of total MTXPGs, short-chain MTXPGs and long-chain MTXPGs (P &gt; 0.05), but it significantly decreased the content of very long-chain MTXPGs (P &lt; 0.05) at week 15.

Conclusions
The UPLC-MS/MS method was successfully used to determine MTXPGs in rat erythrocytes. TGP and TWP in combination with MTX affected the production of MTXPGs of different chain lengths in erythrocytes.
The Zhenhua Case: the emergence of civil environmental public interest litigation in China
Authors: Yan Wenjun 
Published: February 2021

Abstract
In 2015, the All-China Environment Federation v Dezhou Jinghua Group Zhenhua Corporation Limited case was the first civil environmental public interest litigation (CEPIL) against air pollution in China. Constituting a milestone in the field of air pollution control in China, this case (i) confirms the eligibility of a non-governmental organisation (NGO) to file civil public interest litigations; (ii) discusses remedies for the ecological destruction caused by air pollution; (iii) assesses the ecological and environmental damage using the ‘virtual restoration cost’ method; and (iv) uses public apology as an innovative way for Zhenhua to assume liability. By applying and interpreting several important rules under the Environmental Protection Law of China (EPLC) for the first time, this case sets an example for future CEPILs against air pollution in China.
Ammonium supply induces differential metabolic adaptive responses in tomato according to leaf phenological stage
Authors: Poucet Théo , González-Moro María Begoña , Cabasson Cécile , Beauvoit Bertrand , Gibon Yves , Dieuaide-Noubhani Martine , Marino Daniel 
Published: February 2021

Abstract
Nitrate (NO3−) and ammonium (NH4+) are the main inorganic nitrogen sources available to plants. However, exclusive ammonium nutrition may lead to stress characterized by growth inhibition, generally associated with a profound metabolic reprogramming. In this work, we investigated how metabolism adapts according to leaf position in the vertical axis of tomato (Solanum lycopersicum cv. M82) plants grown with NH4+, NO3−, or NH4NO3 supply. We dissected leaf biomass composition and metabolism through an integrative analysis of metabolites, ions, and enzyme activities. Under ammonium nutrition, carbon and nitrogen metabolism were more perturbed in mature leaves than in young ones, overall suggesting a trade-off between NH4+ accumulation and assimilation to preserve young leaves from ammonium stress. Moreover, NH4+-fed plants exhibited changes in carbon partitioning, accumulating sugars and starch at the expense of organic acids, compared with plants supplied with NO3−. We explain such reallocation by the action of the biochemical pH-stat as a mechanism to compensate the differential proton production that depends on the nitrogen source provided. This work also underlines that the regulation of leaf primary metabolism is dependent on both leaf phenological stage and the nitrogen source provided.
Clinical Predictors of SARS-CoV-2 Testing Pressure on Clinical Laboratories: A Multinational Study Analyzing Google Trends and Over 100 Million Diagnostic Tests
Authors: Lippi Giuseppe , Mattiuzzi Camilla , Santos de Oliveira Maria Helena , Henry Brandon M 
Published: February 2021

Abstract

Objective
Evidence has shown that Google searches for clinical symptom keywords correlates with the number of new weekly patients with COVID-19. This multinational study assessed whether demand for SARS-CoV-2 tests could also be predicted by Google searches for key COVID-19 symptoms.

Methods
The weekly number of SARS-CoV-2 tests performed in Italy and the United States was retrieved from official sources. A concomitant electronic search was performed in Google Trends, using terms for key COVID-19 symptoms.

Results
The model that provided the highest coefficient of determination for the United States (R2 = 82.8%) included a combination of searching for cough (with a time lag of 2 weeks), fever (with a time lag of 2 weeks), and headache (with a time lag of 3 weeks; the time lag refers to the amount of time between when a search was conducted and when a test was administered). In Italy, headache provided the model with the highest adjusted R2 (86.8%), with time lags of both 1 and 2 weeks.

Conclusion
Weekly monitoring of Google Trends scores for nonspecific COVID-19 symptoms is a reliable approach for anticipating SARS-CoV-2 testing demands ~2 weeks in the future.
Multiplicity among the cool supergiants in the Magellanic Clouds
Authors: Dorda R , Patrick L R 
Published: February 2021

ABSTRACT
The characterization of multiplicity of high-mass stars is of fundamental importance to understand their evolution, the diversity of observed core-collapse supernovae and the formation of gravitational wave progenitor systems. Despite that, until recently, one of the final phases of massive star evolution – the cool supergiant phase – has received comparatively little attention. In this study, we aim to explore the multiplicity among the cool supergiant (CSG) population in the Large and Small Magellanic Clouds (LMC and SMC, respectively). To do this we compile extensive archival radial velocity (RV) measurements for over 1000 CSGs from the LMC and SMC, spanning a baseline of over 40 yr. By statistically correcting the RV measurements of each stellar catalogue to the Gaia DR2 reference frame we are able to effectively compare these diverse observations. We identify 45 CSGs where RV variations cannot be explained through intrinsic variability, and are hence considered binary systems. We obtain a minimum binary fraction of $15\pm 4{{\ \rm per\ cent}}$ for the SMC and of $14\pm 5{{\ \rm per\ cent}}$ for the LMC, restricting our sample to objects with at least 6 and 5 observational epochs, respectively. Combining these results, we determine a minimum binary fraction of $15\pm 3{{\ \rm per\ cent}}$ for CSGs. These results are in good agreement with previous results which apply a correction to account for observational biases. These results add strength to the hypothesis that the binary fraction of CSGs is significantly lower than their main-sequence counterparts. Going forward, we stress the need for long-baseline multi-epoch spectroscopic surveys to cover the full parameter space of CSG binary systems.
The relationship between photometric and spectroscopic oscillation amplitudes from 3D stellar atmosphere simulations
Authors: Zhou Yixiao , Nordlander Thomas , Casagrande Luca , Joyce Meridith , Li Yaguang , Amarsi Anish M , Reggiani Henrique , Asplund Martin 
Published: February 2021

ABSTRACT
We establish a quantitative relationship between photometric and spectroscopic detections of solar-like oscillations using ab initio, 3D, hydrodynamical numerical simulations of stellar atmospheres. We present a theoretical derivation as a proof of concept for our method. We perform realistic spectral line formation calculations to quantify the ratio between luminosity and radial velocity amplitude for two case studies: the Sun and the red giant ϵ Tau. Luminosity amplitudes are computed based on the bolometric flux predicted by 3D simulations with granulation background modelled the same way as asteroseismic observations. Radial velocity amplitudes are determined from the wavelength shift of synthesized spectral lines with methods closely resembling those used in Birmingham Solar Oscillations Network (BiSON) and Stellar Oscillations Network Group (SONG) observations. Consequently, the theoretical luminosity to radial velocity amplitude ratios are directly comparable with corresponding observations. For the Sun, we predict theoretical ratios of 21.0 and 23.7 ppm [m s−1]−1 from BiSON and SONG, respectively, in good agreement with observations 19.1 and 21.6 ppm [m s−1]−1. For ϵ Tau, we predict K2 and SONG ratios of 48.4 ppm [m s−1]−1, again in good agreement with observations 42.2 ppm [m s−1]−1, and much improved over the result from conventional empirical scaling relations that give 23.2 ppm [m s−1]−1. This study thus opens the path towards a quantitative understanding of solar-like oscillations, via detailed modelling of 3D stellar atmospheres.
White dwarf–main sequence star collisions from wide triples in the field
Authors: Michaely Erez , Shara Michael M 
Published: February 2021

ABSTRACT
Multiple star systems interact strongly with galactic field stars when the outer semi-major axis of a triple or multiple star is &gt;103 AU. Stable triples composed of two white-dwarfs (WD) and a low-mass main sequence (MS) star in a wide outer orbit can thus be destabilized by gravitational interactions with random field stars. Such interactions excite the eccentricity of the distant third star sufficiently so that it begins to interact significantly with the inner binary. When this occurs, the triple undergoes multiple binary-single resonant encounters. These encounters may result either in a collision between the non-degenerate component and a WD, or the breakup of the triple into a compact binary and a third object which is ejected. The compact binary can be either a MS–WD pair which survives, or collides or a double WD (DWD), which may inspiral through gravitational wave emission. We calculate the collision rate between a MS and WD star, and the merger rate of DWDs. Additionally, we describe the prospects of detectability of such a collision, which may resemble a sub-luminous supernovae event.
AlFoCS + F3D – II. Unexpectedly low gas-to-dust ratios in the Fornax galaxy cluster
Authors: Zabel Nikki , Davis Timothy A , Smith Matthew W L , Sarzi Marc , Loni Alessandro , Serra Paolo , Lara-López Maritza A , Cigan Phil , Baes Maarten , Bendo George J , De Looze Ilse , Iodice Enrichetta , Kleiner Dane , Koribalski Bärbel S , Peletier Reynier , Pinna Francesca , de Zeeuw P Tim 
Published: February 2021

ABSTRACT
We combine observations from Atacama Large Millimeter/submillimeter Array (ALMA), Australia Telescope Compact Array, Multi Unit Spectroscopic Explorer (MUSE), and Herschel to study gas-to-dust ratios in 15 Fornax cluster galaxies detected in the FIR/sub-mm by Herschel and observed by ALMA as part of the ALMA Fornax Cluster Survey. The sample spans a stellar mass range of 8.3 ≤  log(M⋆/M⊙) ≤ 11.16, and a variety of morphological types. We use gas-phase metallicities derived from MUSE observations (from the Fornax3D survey) to study these ratios as a function of metallicity, and to study dust-to-metal ratios, in a sub-sample of nine galaxies. We find that gas-to-dust ratios in Fornax galaxies are systematically lower than those in field galaxies at fixed stellar mass/metallicity. This implies that a relatively large fraction of the metals in these Fornax systems is locked up in dust, which is possibly due to altered chemical evolution as a result of the dense environment. The low ratios are not only driven by H i deficiencies, but H2-to-dust ratios are also significantly decreased. This is different in the Virgo cluster, where low gas-to-dust ratios inside the virial radius are driven by low H i-to-dust ratios, while H2-to-dust ratios are increased. Resolved observations of NGC 1436 show a radial increase in H2-to-dust ratio, and show that low ratios are present throughout the disc. We propose various explanations for the low H2-to-dust ratios in the Fornax cluster, including the more efficient stripping of H2 compared to dust, more efficient enrichment of dust in the star formation process, and altered interstellar medium physics in the cluster environment.
Eigenstates of quasi-Keplerian self-gravitating particle discs
Authors: Melton Walker , Batygin Konstantin 
Published: February 2021

ABSTRACT
Although quasi-Keplerian discs are among the most common astrophysical structures, computation of secular angular momentum transport within them routinely presents a considerable practical challenge. In this work, we investigate the secular small-inclination dynamics of a razor-thin particle disc as the continuum limit of a discrete Lagrange–Laplace secular perturbative theory and explore the analogy between the ensuing secular evolution – including non-local couplings of self-gravitating discs – and quantum mechanics. We find the ‘quantum’ Hamiltonian that describes the time evolution of the system and demonstrate the existence of a conserved inner product. The lowest-frequency normal modes are numerically approximated by performing a Wick rotation on the equations of motion. These modes are used to quantify the accuracy of a much simpler local-coupling model, revealing that it predicts the shape of the normal modes to a high degree of accuracy, especially in narrow annuli, even though it fails to predict their eigenfrequencies.