bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidimensional Adaptive Deep Clustering for Intelligent Diagenetic Facies Logging Recognition
Authors: Zhang Liying , He Jingyu , Chen Lumeng , Mao Zhiguo , Shi Bingbo 
Published: February 2025

Summary
Diagenetic facies are indicators that characterize the nature, type, and quality of reservoirs. Identifying diagenetic facies is critical for efficient exploration and development of tight sandstone gas reservoirs. Currently, research on diagenetic facies recognition focuses on the use of supervised learning methods based on labeled data sets. However, the high cost of generating diagenetic facies labels, due to the use of sophisticated instrumentation and expert annotation, limits the generalization of supervised learning methods. Therefore, there is an urgent need for an efficient and adaptive unsupervised learning method in the field of diagenetic facies recognition. In unsupervised learning, diagenetic phase identification faces the problems of complex data distribution and optimizing the number of clusters. To address these issues, we propose a multidimensional adaptive deep clustering model (MADELINE). The advantages of this model are as follows: (1) To address the problem of low-quality feature extraction caused by differences in data distribution, we propose an asymmetric autoencoder module (ASAE) that uses internal features of log data to extract representative multidimensional features of attributes. (2) Design the adaptive cluster number learning module (ACME) to realize adaptive learning of clustering parameters and solve the problem of intelligent optimization of clustering parameters. Log data from six wells (AC, CNL, DEN, GR, SP, RT) in the Ordos Basin and six representative models were selected for comparative experiments. The results show that MADELINE achieves optimal performance in both the Silhouette Coefficient (SC) and the Calinski-Harabasz Index (CHI). The proposed method improves the SC metric by 8.94% compared to classic clustering and deep clustering algorithms. To further verify the effectiveness of MADELINE, ablation experiments, hyperparameter analysis, and visualization analysis of the experimental results were performed. The results of the ablation experiments show that each module of MADELINE plays a positive role, and the asymmetric model structure is more beneficial for feature learning. The MADELINE model proposed in this study effectively solves the problems of data distribution differences and adaptive optimization of cluster numbers in diagenetic facies recognition and provides a low-cost and rapid diagenetic facies recognition method for oil exploration and development. This research has practical application value for reservoir quality evaluation, oil-bearing prediction, and exploration and development decision-making.
Drilling Contracts and Alliances: The Pendulum Swings
Authors: Gooch Stephen G. 
Published: February 2025

Introduction
Use of offshore rigs has increased to levels not seen since the early 1980's, creating supply shortages in many markets, as Figs. 1 through 3 illustrate. This tight market condition is expected to continue for some time because demand is not anticipated to abate and the supply will be relatively static. While rates are approaching levels high enough to encourage new builds, a spate of new construction has not yet ensued. Even if new construction occurs, it will take another 2 or 3 years for deli very of these new rigs. How has and will this tight market condition affect drilling contracts and alliances?

Drilling Contracts
In general, operators have used a favorable supply/demand rig ratio during the past 15 years to reshape drilling contracts in their favor. The current tight market has reversed this trend, at least in part, and is expected to continue to do so. The purpose of this presentation is to focus on certain issues that will be impacted by the tight market, not to seek out perceived inequities in drilling contracts. The following is a discussion of some of these issues.
Impact of Accelerated Seldinger Technique long peripheral catheters on catheter related outcomes: a systematic review and meta-analysis
Authors: Pieteraerens Wouter , Delft Brenda van , Scholliers Annelies , Vanhonacker Domien , Torsy Tim 
Published: February 2025

Abstract

Managing intravenous therapy in patients with difficult intravenous access (DIVA) often requires the use of midline catheters (MCs) or long peripheral catheters (LPCs). This study aimed to review and meta-analyze catheter-related outcomes of LPCs inserted using the Accelerated Seldinger Technique (AST) in adult DIVA patients, focusing on dwell time, catheter-related infections, thrombosis, infiltration, occlusion, phlebitis and other outcomes. A systematic review was conducted on quantitative studies from 2000 to 2023, sourced from databases including CINAHL, Cochrane Library, Google Scholar and PubMed, to identify studies on adult DIVA patients requiring AST-LPCs. The review adhered to PRISMA guidelines, and the Quality Assessment Tool for Quantitative Studies was used to ensure rigorous evaluation. Of 1017 records initially reviewed, 11 studies were included in the final analysis. The mean dwell time for LPCs ranged from 2.92 (± 0.54) to 17.1 (± 12.3) days. A meta-analysis showed a significant mean difference in dwell time of 1.98 days (± 1.16 to 2.80) in favor of LPCs over short peripheral catheters (p < 0.00001). Reported complications included infiltration (up to 24%), dysfunction (up to 15.7%), thrombosis (up to 15.4%), catheter-related infections (up to 10.2%), occlusion (up to 10.2%) and phlebitis (up to 9.8%). The findings suggest that AST-LPCs may offer greater durability than short peripheral catheters in DIVA patients. While MCs may be more effective for therapies exceeding four weeks, they involve higher procedural complexities. This review highlights the need for high-quality randomized studies comparing AST-LPCs, MCs, and newer catheter-over-needle LPCs to better inform vascular access specialists in managing DIVA patients. Prospero ID: CRD42023425513
Bladder instillation cocktail for preventing catheter-related bladder irritation after gynecologic surgery: a double-blind, randomized, placebo- controlled study
Authors: Liu Yuwen , Zheng Xiangying , Wei Tao , Gu Yajuan , Deng Chao 
Published: February 2025

Abstract

Background:
Catheter-related bladder discomfort (CRBD) can lead to decreased patient satisfaction and increased postoperative adverse events. Although existing prevention methods for CRBD have demonstrated certain therapeutic effects, they may cause various adverse reactions. In this study, a "cocktail" reagent containing a combination of three drugs, including ropivacaine, dexamethasone, and magnesium sulfate, was used. This study aimed to investigate whether bladder instillation of a "cocktail" can prevent postoperative CRBD in gynecological patients.
Methods:
This double-blind, prospective, randomized controlled clinical study included 112 patients randomly divided into two groups: 56 patients in the "cocktail" group and 56 patients in the control group. Patients in the "cocktail" group received an intravesical infusion of the "cocktail" ("cocktail" formula included 20 mL of 1% ropivacaine + 5 g of magnesium sulfate injection + 10 mg of dexamethasone, all diluted to a total volume of 32 mL), while those in the control group received an intravesical infusion of 32 mL of physiological saline. After bladder instillation in all patients, the catheter was clamped for 20 min. The CRBD and visual analog scale (VAS) of the patients were recorded at 0, 1, 2, and 6 h after surgery. The 15-item Quality of Recovery (QoR-15) scale was used 24 h after surgery to assess the patient's postoperative recovery status.
Results:
The "cocktail" group exhibited significantly decreased CRBD severity at 0, 1, 2, and 6 h postoperatively (P = 0.002, P < 0.001, P < 0.001, and P < 0.001, respectively). Specifically, compared with the control group, the "cocktail" group exhibited a significant decrease in moderate-to-severe CRBD at 0, 1, and 2 h postoperatively (P = 0.040, P = 0.043, P = 0.031, respectively). Moreover, patients in the "cocktail" group exhibited significantly higher postoperative recovery scale scores compared to those in the control group (P < 0.001).
Conclusion:
Bladder instillation of the "cocktail" can prevent catheter-related bladder irritation and improve postoperative recovery in gynecologic patients.
Trial registration:
This trial was a retrospective registration with the Chinese Clinical Trial Registry (No. ChiCTR2300078550), registered on December 12, 2023.
Early Alzheimer’s brain atrophy in entorhinal cortex is associated with HSD11B1-cortisol axis in APOE4 carriers
Authors: Lai Rai-Hua , Chung Ren-Hua , Hsu Paul Wei-Che , Chen Yi-Chung , Lam Ka-Hei , Pai Wan-Yu , Juang Jyh-Lyh 
Published: February 2025

Abstract

Background
Entorhinal cortex (EC) atrophy, driven by tau pathology, is an early hallmark of Alzheimer’s disease (AD), preceding hippocampal degeneration. APOE4, the strongest genetic risk factor for AD, is linked to increased tau accumulation and impaired Aβ clearance in the EC. However, the specific cellular factors associated with APOE4 that contribute to this selective vulnerability remain unclear.
Methods
Longitudinal brain imaging, plasma biomarkers, and genetic polymorphism data from mild cognitive impairment (MCI) participants in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed. Linear regression and genetic association analyses were conducted to identify factors associated with entorhinal cortex volume, with stratified analyses examining the influence of APOE4 genotype.
Results
Cortisol, α1-antichymotrypsin (AACT), and trefoil factor 3 (TFF3) were identified as potential contributors to EC volume changes. Elevated plasma cortisol levels were significantly associated with EC volume decline in APOE4 carriers with MCI (p = 0.0043) and predicted a faster progression from MCI to AD (p = 0.040), whereas no such association was observed in noncarriers. HSD11B1, an enzyme responsible for converting cortisone to cortisol, showed higher expression in the EC compared to the hippocampus. Genetic analysis identified two functional HSD11B1 variants (rs2282738 and rs2282739) associated with elevated cortisol levels and increased AD risk. Notably, rs2282738 was significantly linked to EC volume decline (p = 0.0494), while no significant association was observed in the hippocampus.
Conclusion
Our findings suggest that HSD11B1-mediated local cortisol activation may contribute to entorhinal cortex vulnerability in APOE4 carriers with MCI, potentially accelerating AD onset. Targeting HSD11B1 could represent a promising therapeutic strategy to mitigate EC atrophy and slow disease progression in APOE4 carriers.
Artificial Intelligence-Assisted Quality Control Circles Led by Clinical Pharmacists to Improve the Rational Use of Injectable Proton Pump Inhibitors in Hospitalised Patients
Authors: Zhang Ming , Ma Wei-cheng , He Wen-yue 
Published: February 2025

Abstract

Proton pump inhibitors (PPIs) are a class of drugs that inhibit gastric acid secretion, and their overuse in clinical practice are relativity common. We developed a quality control circles (QCC) assisted by artificial intelligence (AI) and led by clinical pharmacists to improve the rational use of (PPIs) among hospitalised patients at our hospital. A QCC team was established to follow QCC procedures. The root causes of inappropriate use were identified using AI-assisted brainstorming, and corresponding strategies were developed. The rational use rates of injectable PPIs before and after QCC implementation were calculated and compared. After QCC implementation, the rational use rate of injectable PPIs among hospitalised patients in our hospital increased from 66.51–93.43%, with a goal achievement rate of 126.92% and a progression rate of 40.47%. The increase in the rational use rate of PPIs was statistically significant (P < 0.001). Additionally, team cohesion, responsibility and proficiency in QCC techniques improved after QCC implementation. Furthermore, the standardised process for using injectable PPIs became more regulated after QCC implementation. AI-assisted, clinical pharmacist-led QCCs can serve as an efficient management tool for improving the rational use of injectable PPIs in hospitalised patients, thereby advancing the work of rational drug use in clinics.
Comparative Study on Positioning Error Analysis and PTV Expansion Standards for Multi-Site Radiotherapy Based on TOMO and TrueBeam Accelerators
Authors: Gui Longgang , Shi Miao , Li Jun , Wang Lin 
Published: February 2025

Abstract

Objective
To establish recommended PTV expansion values for head-neck, thoracic, and abdominopelvic regions based on MVCT data from the TOMO system, compare them with TrueBeam expansion standards, and explore the impact of device characteristics on error distribution.
Methods
Patients treated with TOMO or TrueBeam at Subei People’s Hospital from March 2024 to February 2025 were included. The TOMO group underwent daily MVCT scans, while the TrueBeam group used daily CBCT registration. Translational errors were recorded. SPSS26 was used to calculate systematic error (Σ) and random error (σ). The expansion formula (MPTV = 2.5Σ + 0.7σ) was applied to compute expansion values, and independent-sample t-tests were conducted to compare inter-device differences.
Results
Positioning errors followed the trend: head-neck < thoracic < abdominopelvic. Errors in the SI (superior-inferior) direction were consistently higher than those in LR (left-right) and AP (anterior-posterior) directions. TrueBeam exhibited significantly higher random errors in the AP direction than TOMO. Significant differences in expansion values between devices were observed in all head-neck directions and SI/AP directions of the abdominopelvic region, but not in thoracic directions. TOMO demonstrated significantly lower head-neck expansion values than TrueBeam. For thoracic regions, TrueBeam showed the highest SI-direction expansion value. In the abdominopelvic region, TrueBeam’s SI-direction expansion value was significantly higher than TOMO’s.
Conclusion
TOMO is more suitable for high-precision radiotherapy in head-neck and pelvic regions. TrueBeam requires integration with respiratory management techniques to optimize thoracoabdominal treatment. Clinically, PTV expansion standards should be dynamically adjusted based on tumor location and device characteristics. Future studies should incorporate deformable registration and artificial intelligence to develop real-time error prediction models.
ERD Full-process Longitudinal Trend and Pre-post Motor Recovery Under BCI-controlled Sixth-finger Neurofeedback Intervention in Stroke Patients
Authors: Zhuang Wang , Yuan Liu 
Published: February 2025

Abstract

Background Brain-computer interface (BCI) is used in stroke rehabilitation to match brain activity with contingent feedback to establish closed-loop pathways and provide a measure of neuroplasticity changes of patients. However, most studies assessed neural function only at pre- and post-intervention, thereby longitudinal trends of neural patterns and mechanismsduring full-process of intervention remain unclear.
Methods Forty stroke patients were recruited to receive a total of 8 sessions motor imagery-based (MI-based) BCI-controlled “sixth-finger” neurofeedback intervention, 4 sessions per week for 2 weeks. Electroencephalography (EEG) measure and clinical scales were assessed at three time points: baseline, post-train and 1month follow-up period, and EEG data of each intervention sessions were also tracked. ERD phenomenon induced by MI and resting-state functional connectivity were used to reflect the longitudinal trends and pre-post changes in neural activity. The upper extremity Fugl-Meyer assessment (FMA-UE) and Barthel index (BI) were used to reflect the motor improvement.
Results EEG longitudinal trend shows three phases over full-process of intervention: ERD gradually increased in the first week of training, weakened and focused on the contralateral sensorimotor area in the second week, and showed a significant correlation over sessions, remaining focused and contralateral pattern in the follow-up period. And resting-state functional connectivity increased after intervention. Motor function between pre-post intervention showed significant improvement by clinical metrics, with + 7.9 in FMA-UE and + 7.1 in BI. More than half of patients (9/14) reached the minimally clinically important difference (MCID) of 6.6 points change for FMA-UE after therapy. Meanwhile the improvement was maintained until the one-month follow-up after the end of therapy. In addition, improvement of motor function is associated with the enhancement of resting-state functional connectivity.
Conclusions This work reveals longitudinal trend of neural patterns over full-process of intervention and its correlation with motor recovery, so as to provide more evidence for a detailed understanding of the mechanism of neural plasticity.
Effects of sleep quality on the default mode network and on anxiety- depression symptoms in premenstrual syndrome
Authors: Qin Haixia , Zhang Yan , Li Shanshan , Ou Yuanyuan , Lin Shihuan , Lai YinQi , Zhang Qingping , Zhou Kaixuan , Sun Ruijing , Wu Yuejuan , Liu Zhen , Lai Ziyan , Chen Ya , Wu Rongcai , Chen Zhizhong , Zhang Hui , Duan Gaoxiong , Deng Demao 
Published: February 2025

Abstract

Background
Neuroimaging evidence suggests existence of an association between the aberrant default mode network (DMN) and anxiety-depression severity in premenstrual syndrome (PMS); however, ignoring the effects of sleep prevents understanding the pathophysiology of PMS.
Methods
Seventy-seven PMS patients and sixty-six healthy controls (HCs) underwent resting-state functional MRI, and clinical assessment included the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale. PSQI scores classified PMS patients into normal sleep quality (PMS-NSQ) and poor sleep quality (PMS-PSQ) groups. Resting-state functional connectivity (rsFC) and regional homogeneity (ReHo) within the DMN were compared among the three groups. Correlation and mediation analyses examined potential associations relating sleep quality, changes in brain function, and clinical variables.
Results
Compared to HCs, both PMS groups exhibited increased rsFC between left inferior parietal lobule (IPL) and right middle occipital gyrus. Additionally, the PMS-NSQ group presented decreased FC of right ventromedial prefrontal cortex (VMPFC) and right posterior cingulate/precuneus, decreased ReHo in right VMPFC, and increased ReHo value in left IPL. Combined correlation and mediation analyses showed that the altered functional activity within the DMN and anxiety-depression symptoms were mediated by sleep quality in PMS patients, mainly involving the right VMPFC and left IPL regions of the brain.
Conclusions
The findings reveal the potential neuropathology of sleep problems in PMS, which sleep quality may mediate the association between functional connectivity within DMN and anxiety-depression severity. The right VMPFC and the left IPL may prospectively serve as potential intervention targets for the treatment of sleep disturbances in PMS.
Trial registration: Chinese Clinical Trial Registry (ChiCTR1900020642)
Physical activity advice from general practitioners in Germany: Findings from a cross-sectional population survey of individuals with chronic ischemic heart disease (OptiCor study)
Authors: Hoppe Sabrina , Prinz Alicia , Kotz Daniel , Mons Ute , Kuß Oliver , Crutzen Rik , Kastaun Sabrina 
Published: February 2025

Abstract

Objectives: The current German treatment guideline for chronic ischemic heart disease (IHD) recommends that general practitioners (GPs) deliver brief advice on physical activity (PA) to IHD patients. Such advice consists of at least three elements (i.e., 3As): (1) assessing the PA level, (2) advising on PA, and (3) assisting with recommendations. This study examined the extent to which individuals with IHD in Germany reported the receipt of such advice.
Design: Cross-sectional population-based face-to-face survey (06/2023-08/2024).
Setting: Germany.
Participants: 1,004 individuals aged 35+ with self-reported IHD and GP contact.
Outcome measures: Primary outcome: Self-reported proportions of receipt of GP-delivered PA advice according to the 3As. Main secondary outcome: Associations between person characteristics and the likelihood of receiving PA advice.
Results: Among individuals with IHD, 36.4% (95% CI=33.4 to 39.4) received all 3As of PA advice, 42.1% (95% CI=39.1 to 45.2) received one or two elements, 9.9% (95% CI=8.1 to 11.8) received no advice at all, and 3.8% (95% CI=2.7 to 5.1) were advised to avoid PA (7.9% did not remember/refused to answer). Women (vs. men) were more likely to receive no advice (OR=1.74, 95% CI=1.11 to 2.72), while individuals with higher PA levels (OR=0.82, 95% CI=0.75 to 0.90, per hour/week) and those with higher (vs. lower) education were less likely to receive no advice (OR=0.39, 95% CI= 0.20 to 0.76). Individuals living in urban (vs. rural) areas were less likely to receive only one or two (vs. all) of the 3As (OR=0.65, 95% CI=0.46 to 0.88). Of those who received at least one element of advice (n=766), 72.5% reported they were more active afterwards, with a higher proportion when all 3As (vs. only some elements) were provided (86.8% vs. 59.6%).
Conclusions: Only one-third of individuals with IHD in Germany received comprehensive PA advice. Specific person characteristics, such as female gender and lower education, were associated with lower proportions of received PA advice. Efforts are needed to improve GP-led PA guidance, particularly for underserved groups.
Trial registration: German Clinical Trials Register (DRKS00031304)
Az edző szerepe a sportoló fiatalok táplálkozásában
Authors: Biróné Ilics Katalin , Nagyváradi Katalin , Stelczer Ádám 
Published: February 2025

Munkánk elsődleges célja az edző szerepének vizsgálata a sportolók táplálkozásában. Arra a kérdésre kerestük a választ, hogy: Vajon az edző munkája kiterjed-e a sportolók táplálkozási szokásainak ellenőrzésére, nyomon követésére?
Vizsgálatunkba 6 sportág I. és II. osztályú utánpótlás korú versenysportolóit vontuk be (N= 162). Saját készítésű kérdőívünkben felhasználtuk az Élelmiszerfogyasztási Gyakorisági kérdőív egyes kérdéseit.
A válaszadók 54%-a arról nyilatkozott, hogy senkitől sem kap táplálkozási tanácsot. 23%-uk a csapat dietetikusától, 16%-uk az edzőtől, további 6%-uk az erőnléti edzőtől, és néhányan (1 %) a gyógytornásztól.
A sportolók jelentős többsége (74,6 %) fogyaszt étrend-kiegészítőt. Ezek használatához leginkább a szülőktől (27%), és a dietetikustól (26%) kértek tanácsot. Az edző szerepe ebben a kérdésben is elenyésző (6%) volt.
A sportolók igényei miatt szükség lenne szakemberek bevonására az egyesületek táplálkozási alapelveinek kidolgozásához azért, hogy tudjanak személyre szabott táplálkozási tanácsokat adni, étrendet tervezni, és az étrend-kiegészítők fogyasztását szakszerűen alkalmazni. Az edző segítheti ezen elvek betartásának ellenőrzését.