bluuebunny/crossref_metadata_2025_split huggingface dataset:
Past, present, and future of green product innovation
Authors: Khan Sher Jahan , Dhir Amandeep , Parida Vinit , Papa Armando 
Published: July 2021

AbstractFirms are under constant pressure from various governmental and nongovernmental agencies to switch from conventional environmentally polluting products to green product innovations (GPIs). However, the relevant research pertaining to GPI has been published in a diverse set of journals that vary in their scope and readership and, therefore, the scholarly contribution to the topic remains largely fragmented. This study has utilised a systematic literature review approach to examine the literary corpus on GPI to paint a holistic picture of its different aspects. The content and thematic analysis of 85 studies resulted in the extraction of seven key research themes: organisational capabilities, organisational learning, institutional pressures, barriers, structural changes, benefits of GPI, and methodological choices. This study's findings further highlight the various gaps in the GPI literature and raise some research questions that warrant scholarly investigation in the future. Likewise, our study has important implications for practitioners who are likely to benefit from a holistic understanding of the different aspects of GPI. Similarly, policymakers can use this study's findings to introduce policy interventions, especially in countries where GPI adoption is low.
Functional neurological symptoms: Optimising efficacy of inpatient treatment and preparation for change using the Queen Square Guided Self‐Help
Authors: Humblestone Susan , Roelofs Jacob , Selai Caroline , Moutoussis Michael 
Published: July 2021

AbstractObjectiveFunctional neurological symptoms (FNS) are disabling symptoms without macro‐structural cause. While inpatient treatment confers important benefits, it is resource‐intensive, and hence, it is important to optimise its efficiency.MethodsWe developed a brief, Internet‐based preparatory therapy based on psychoeducation and CBT, termed the Queen Square Guided Self‐help (QGSH), to maximise the efficacy of the inpatient FNS treatment at the National Hospital for Neurology and Neurosurgery.ResultsThe QGSH aims to ensure that prior to admission, the patient understands (a) the diagnosis of FNS, (b) the five‐areas CBT model and (c) the use of goal setting in rehabilitation. It has now run since 2017, and 191 patients have taken part in the inpatient FNS programme, with 122 of these having participated in the QGSH. It runs for up to 12 weeks and includes original videos and patient worksheets, as well as signposting to existing published resources. Information is sent weekly by email, and content is delivered in the form of 11 modules built around online video sessions.ConclusionWe believe that the set of materials used in QGSH has the potential to benefit patients with FNS and can support clinicians wishing to develop their expertise. It could help with the development of new FNS services, and we are in the process of developing it into a stand‐alone service. We hope that the experience of the Queen Square team can be used to help patients and clinicians to improve the provision of FNS services.
Fluctuation in electrical hearing in a Morbus Meniere’s patient
Authors: Hast Anne , Meßbacher Maria‐Elena , Liebscher Tim , Hornung Joachim , Hoppe Ulrich 
Published: July 2021

AbstractThe glycerol test is an easy‐to‐use instrument to elucidate fluctuations of electrical hearing in patients with Meniere's disease and it might be also used as a therapeutic option.
Recurrent chest pain as a rare presentation of extra‐pelvic endometriosis
Authors: Hussein Mousa , Albakri Mutaz , Ismail Shanima , Alabbas Abbas , Al Hyassat Samir 
Published: July 2021

AbstractPeriodic chest pain, with bloody pleural effusion should raise the suspicion of pleural endometriosis as a well‐known, but a rare condition in clinical practice.
A diffuse large B‐cell thyroid lymphoma presented as a compressive goiter in a young woman with no evidence of Hashimoto's thyroiditis
Authors: Oueslati Ibtissem , Chatti Hiba‐Allah , Yazidi Meriem , Chaker Fatma , Chihaoui Melika 
Published: July 2021

AbstractThyroid lymphoma should be suspected in case of rapid enlargement of the thyroid gland even in a young patient with no history of Hashimoto thyroiditis. The confirmation is based on histopathology and immunohistochemistry.
Procedure of choice in a patient initially operated for a suspected epithelial appendiceal neoplasm
Authors: Xenou Antigoni , Vranou Eugenia , Boulas Konstantinos A. , Nathanailidou Maria , Kyriakidou Eytyxia , Sitaridis Konstantinos , Filippidis Isaac , Hatzigeorgiadis Anestis 
Published: July 2021

AbstractIn patients operated for a suspected appendiceal neoplasm, radical appendectomy is the procedure of choice because it provides definitive treatment in most of appendiceal neoplasms, except from mucinous or colonic‐type adenocarcinoma and NET>2 cm.
Hyponatremia and extrapontine myelinolysis in a patient with COVID‐19: A case report
Authors: Abd Ur Rehman Muhammad , Abdulrahman Abdulrahman Fadhl , Zainab Aariz , Paksoy Yahya , Kharma Nadir 
Published: July 2021

AbstractUntil we have strong evidence to the contrary, symptomatic hyponatremia should be treated with extra caution in COVID‐19 co‐infection patients as the latter could be another risk factor for the development of extrapontine myelinolysis.
A 70‐Year‐Old Mystery in Technetium Chemistry Explained by the New Technetium Polyoxometalate [H7O3]4[Tc20O68] ⋅ 4H2O
Authors: German Konstantin E. , Fedoseev Alexander M. , Grigoriev Mikhail S. , Kirakosyan Gayane A. , Dumas Thomas , Den Auwer Christophe , Moisy Philippe , Lawler Keith V. , Forster Paul M. , Poineau Frederic 
Published: July 2021

Abstract[H7O3]4[Tc20O68] ⋅ 4H2O [1] was prepared from an aqueous Tc2O7 solution concentrated over anhydrous H2SO4. [Tc20O68]4− is the first polyanionic species to be reported for Tc. The unit cell contains one centrosymmetric [Tc20O68]4− polyanion as well as hydronium ions and water molecules. The core of the structure consists of four Tc(V)O6 octahedra that form a square Tc4O4 ring. The four Tc(V)O6 octahedra are decorated by sixteen Tc(VII)O4 tetrahedra. Calculations show the bonding within the Tc4O4 ring to consist of a 3‐center bond formed between each neighboring pair of Tc atoms and their bridging oxygen. Calculations also indicate that a strong d→d electronic transition at 513 nm is the origin of the red color of [1]. The characterization of red HTcO4 solutions by X‐ray absorption spectroscopy has complemented the description of this compound in aqueous solution. The formation mechanisms in solution, including the possible role of technetium's radioactivity in the formation of [1], are discussed.
Recruitment, outcomes, and toxicity trends in phase I oncology trials: Six‐year experience in a large institution
Authors: Menon Siddharth , Davies Amy , Frentzas Sophia , Hawkins Cheryl‐Ann , Segelov Eva , Day Daphne , Markman Ben 
Published: July 2021

AbstractBackgroundWith the rapid influx of novel anti‐cancer agents, phase I clinical trials in oncology are evolving. Historically, response rates on early phase trials have been modest with the clinical benefit and ethics of enrolment debated. However, there is a paucity of real‐world data in this setting.AimTo better understand the changing landscape of phase I oncology trials, we performed a retrospective review at our institution to examine patient and trial characteristics, screening outcomes, and treatment outcomes.Methods and resultsWe analyzed all consecutive adult patients with advanced solid organ malignancies who were screened across phase I trials from January 2013 to December 2018 at a single institution. During this period, 242 patients were assessed for 28 different trials. Median age was 64 years (range 30–89) with an equal sex distribution. Among 257 screening visits, the overall screen failure rate was 18%, resulting in 212 patients being enrolled onto a study. Twenty‐six trials (93%) involved immunotherapeutic agents or molecular targeted agents either alone or in combination, with only two trials of cytotoxic agents (7%). Twenty‐two (13.4%) of the 209 treated patients experienced a total of 33 grade 3 or higher treatment‐related adverse events. There was one treatment‐related death (0.5%). Of 190 response‐evaluable patients, 7 (4%) had a complete response, 34 (18%) a partial response, and 59 (31%) experienced stable disease for a disease control rate of 53%. The median overall survival for our cohort was 8.0 (95% CI: 6.8–9.2) months.ConclusionThe profile of phase I trials at our institution are consistent with the changing early drug development landscape. Response rates and overall survival in our cohort are superior to historically reported rates and comparable to contemporaneous studies. Severe treatment‐related toxicity was relatively uncommon, and treatment‐related mortality was rare.
Impact of consensus guidelines for breast‐conserving surgery in patients with ductal carcinoma in situ
Authors: Tremelling Abigail , Aft Rebecca L. , Cyr Amy E. , Gillanders William E. , Glover‐Collins Katherine , Herrmann Virginia , Margenthaler Julie A. 
Published: July 2021

AbstractBackgroundConsensus guidelines published in 2016 recommended a 2 mm free margin as the standard for negative margins in patients undergoing breast‐conserving surgery (BCS) for ductal carcinoma in situ (DCIS). The goal of the guideline recommendation was standardization of re‐excision practices.AimsTo evaluate the impact of this consensus guideline on our institutional practices.MethodsWe identified all patients at our institution with pure DCIS who were initially treated with BCS from September 2014 to August 2018 using a prospectively‐maintained institutional database. A retrospective chart review was performed to determine margin status and re‐excision rates during the 2 years before and the 2 years after the guideline was published in order to determine the effect on our re‐excision rates. Close margins were defined as <2 mm.ResultsIn the 2 years before the consensus guideline was published, 184 patients with DCIS underwent BCS. Twenty‐six patients had positive margins and 24 underwent re‐excision, including three who had completion mastectomy. Of the remaining 159 patients, 76 had ≥2 mm (negative) margins. The remaining 82 patients had close margins and 48 of these patients (58.5%) underwent re‐excision, including one who had a completion mastectomy. Excluding the patients with positive margins, our re‐excision rate was 30.4% prior to the guideline. In the 2 years after the consensus guideline was published, 192 patients with DCIS underwent initial BCS. Twenty‐four patients had positive margins and 22 underwent re‐excision, including three who had completion mastectomy. Of the remaining 168 patients, 95 patients had ≥2 mm (negative) margins. The remaining 73 patients had close margins and 45 of those patients (61.6%) underwent re‐excision, including six who had completion mastectomy. Excluding the patients with positive margins, our re‐excision rate was 26.8% after the guideline.ConclusionsOur institution's re‐excision rate did not change significantly during the 2 years before and after the publication of the consensus guideline on adequate margins for patients undergoing BCT for DCIS. Our overall re‐excision rate decreased slightly. However, of the patients who had close margins, a larger proportion underwent re‐excision after the guideline was published. The guideline publication appears to have affected our institutional practices slightly, but not dramatically as many of our surgeons' practices were comparable to the guideline recommendations prior to 2016. We continue to use clinical judgment based on patient and tumor characteristics in deciding which patients will benefit from margin re‐excision.
Neutrophils and their role in the aetiopathogenesis of type 1 and type 2 diabetes
Authors: Giovenzana Anna , Carnovale Debora , Phillips Brett , Petrelli Alessandra , Giannoukakis Nick 
Published: July 2021

AbstractMultiple and complex aetiological processes underlie diabetes mellitus, which invariably result in the development of hyperglycaemia. Although there are two prevalent distinct forms of the disease, that is, type 1 and type 2 diabetes, accumulating evidence indicates that these syndromes share more aetiopathological mechanisms than originally thought. This compels a rethinking of the approaches to prevent and treat the different manifestations of what eventually becomes a hyperglycaemic state. This review aims to address the involvement of neutrophils, the most abundant type of granulocytes involved in the initiation of the acute phase of inflammation, in the aetiopathogenesis of diabetes mellitus, with a focus on type 1 and type 2 diabetes. We review the evidence that neutrophils are the first leucocytes to react to and accumulate inside target tissues of diabetes, such as the pancreas and insulin‐sensitive tissues. We then review available data on the role of neutrophils and their functional alteration, with a focus on NETosis, in the progression towards clinical disease. Finally, we review potential approaches as secondary and adjunctive treatments to limit neutrophil‐mediated damage in the prevention of the progression of subclinical disease to clinical hyperglycaemia.
Environment, vector, or host? Using machine learning to untangle the mechanisms driving arbovirus outbreaks
Authors: Alkhamis Moh A. , Fountain‐Jones Nicholas M. , Aguilar‐Vega Cecilia , Sánchez‐Vizcaíno José M. 
Published: July 2021

AbstractClimatic, landscape, and host features are critical components in shaping outbreaks of vector‐borne diseases. However, the relationship between the outbreaks of vector‐borne pathogens and their environmental drivers is typically complicated, nonlinear, and may vary by taxonomic units below the species level (e.g., strain or serotype). Here, we aim to untangle how these complex forces shape the risk of outbreaks of Bluetongue virus (BTV); a vector‐borne pathogen that is continuously emerging and re‐emerging across Europe, with severe economic implications. We tested if the ecological predictors of BTV outbreak risk were serotype‐specific by examining the most prevalent serotypes recorded in Europe (1, 4, and 8). We used a robust machine learning (ML) pipeline and 23 relevant environmental features to fit predictive models to 24,245 outbreaks reported in 25 European countries between 2000 and 2019. Our ML models demonstrated high predictive performance for all BTV serotypes (accuracies > 0.87) and revealed strong nonlinear relationships between BTV outbreak risk and environmental and host features. Serotype‐specific analysis suggests, however, that each of the major serotypes (1, 4, and 8) had a unique outbreak risk profile. For example, temperature and midge abundance were as the most important characteristics shaping serotype 1, whereas for serotype 4 goat density and temperature were more important. We were also able to identify strong interactive effects between environmental and host characteristics that were also serotype specific. Our ML pipeline was able to reveal more in‐depth insights into the complex epidemiology of BTVs and can guide policymakers in intervention strategies to help reduce the economic implications and social cost of this important pathogen.
Pilot outcomes from a multidisciplinary telehealth versus in‐person intensive outpatient program for eating disorders during versus before the Covid‐19 pandemic
Authors: Levinson Cheri A. , Spoor Samantha P. , Keshishian Ani C. , Pruitt Alexandria 
Published: July 2021

AbstractIntroductionEating disorders (EDs) are serious mental illnesses with high rates of mortality, morbidity, and personal and societal costs. Onset of the Covid‐19 pandemic led to increased ED diagnoses in the general public, as well as worsening of ED symptoms in those with an existing ED diagnosis. Heightened prevalence and severity of EDs during the pandemic is complicated by the fact that traditional modes of ED care (specialty intensive treatment provided by a multidisciplinary team) have been difficult to access during the pandemic.MethodsThe current between‐groups study (N = 93 ED) tested a multidisciplinary intensive outpatient program (IOP) delivered via in‐person (pre‐pandemic; n = 60) and virtually via telehealth (during the pandemic; n = 33).ResultsWe found no differences in outcomes via delivery mode, such that regardless of in‐person versus telehealth programming, ED symptoms, depression, and perfectionism significantly decreased and body mass index significantly increased.ConclusionsOur findings suggest that a multi‐disciplinary telehealth ED IOP program is feasible and has comparable outcomes to in‐person IOP treatment. These findings have implications for treatment beyond the pandemic, suggesting that adoption of telehealth IOPs is warranted. Such delivery modes of intensive treatments for EDs could be expanded to reach underserved populations, especially in rural areas where treatment is often difficult to access.
Streetlights positively affect the presence of an invasive grass species
Authors: Murphy Shannon M. , Vyas Dhaval K. , Hoffman Jennifer L. , Jenck Clara S. , Washburn Brooke A. , Hunnicutt Kelsie E. , Davidson Angie , Andersen Jasmine M. , Bennet Rachel K. , Gifford Amarin , Herrera Mia , Lawler Braelynn , Lorman Sophie , Peacock Vanessa , Walker Lyndi , Watkins Esme , Wilkinson Lakyn , Williams Zariah , Tinghitella Robin M. 
Published: July 2021

AbstractAnthropogenic disturbances associated with urban ecosystems can create favorable conditions for populations of some invasive plant species. Light pollution is one of these disturbances, but how it affects the growth and establishment of invasive plant populations is unknown. Cheatgrass (Bromus tectorum) is a problematic invasive species where it has displaced native grassland communities in the United States, but to our knowledge, there have been no studies of the ecological factors that affect cheatgrass presence in urban ecosystems. We conducted field surveys in urban alleys in Denver, Colorado, to compare the presence of cheatgrass at sites with and without artificial light at night (hereafter artificial light) from streetlights. These streetlights are mounted on utility poles, which cause ground disturbance when installed in alleys; we were able to test the independent effect of poles on cheatgrass establishment because not all poles have streetlights on them. We found that cheatgrass was positively associated with the presence of streetlights and to a lesser extent poles. In addition to cheatgrass, we also found that other plants were positively associated with the presence of both poles and streetlights. Our results suggest that artificial light may benefit the occurrence of cheatgrass and other plant species in urban settings. While invasive populations of cheatgrass in wild habitats attract the most attention from managers, we suggest more consideration for this grass in urban environments where its growth and establishment benefit from anthropogenic changes.
Natural distinction of carbon and nitrogen isotopic niches in common fish species across marine biotopes in the Yellow River estuary
Authors: Qu Pei , Pang Min , Qu Fangyuan , Li Zhao , Xiao Meng , Zhang Zhaohui 
Published: July 2021

AbstractStable isotope analysis is a universally recognized and efficient method of indicating trophic relationships that is widely applied in research. However, variation in stable isotope ratios may lead to inaccuracies due to the effects of complex environmental conditions. This research compared the carbon and nitrogen isotopic niches of fish communities between diverse biotopes around the Yellow River estuary and adjacent sea areas, with the aim of revealing distinctions in stable isotopic niche metrics, trophic positions, and feeding preferences. Our analysis of the food source contribution indicated that allochthonous sources were considered major energy sources in estuarine areas directly affected by Yellow River‐diluted water, while autochthonous benthic and pelagic producers dominated carbon input into the food web in Laizhou Bay and the open water. A significant variation in the fish δ15N characteristic was found within estuarine adjacent regions, so, together with the results from previous studies, we deemed the local high concentration of dissolved inorganic nitrogen as the original trigger of the abnormal δ15N characteristic in fishes via a transport process along food chains. These results provide a new perspective on the natural distinction of carbon and nitrogen isotopic niches. The detailed data reported here enhance our understanding of variations in fish communities in estuarine ecosystems.
Risk of mortality among inpatients with COVID‐19 and type 2 diabetes: National data from Kuwait
Authors: Al‐Ozairi Ebaa , Brown Rosemary , Hamdan Yasmine , Alabdullah Lulwa , Voase Nia , Al Kandari Jumana , Alsaeed Dalal , Al Ozairi Abdulla , Hasan Amal , Al‐Mulla Fahd , Katikireddi Srinivasa Vittal , Gray Stuart R. , Gill Jason M. R. , Celis‐Morales Carlos A. , Sattar Naveed , Welsh Paul 
Published: July 2021

AbstractIntroductionTo investigate type 2 diabetes as a risk factor for COVID‐19 death following hospital admission in Kuwait.MethodsA retrospective cohort study using data from a central hospital that cared for all hospitalized COVID‐19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID‐19 mortality using multiply imputed logistic regression and calculated the population attributable fraction.ResultsA total of 5333 patients were admitted with COVID‐19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID‐19 death was 19.6% (95% CI 10.8, 35.6).ConclusionType 2 diabetes is a strong risk factor for COVID‐19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.
Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways
Authors: Xiong Yanlei , Wang Yueming , Xiong Yanlian , Teng Lianghong 
Published: July 2021

AbstractHigh‐altitude hypoxia‐induced oxidative stress and inflammation played an essential role in the incidence and development of liver injury. Salidroside (Sal), a phenylpropanoid glycoside extracted from the plant Rhodiola rosea, has recently demonstrated antioxidant, anti‐inflammatory, and antihypoxia properties. Herein, we hypothesized that salidroside may alleviate hypoxia‐induced liver injury via antioxidant and antiinflammatory‐related pathways. A high‐altitude hypoxia animal model was established using hypobaric chamber. Male SD rats were randomly divided into the control group, hypoxia group, control +Sal group, and hypoxia +Sal group. Salidroside treatment significantly inhibited hypoxia‐induced increases of serum and hepatic pro‐inflammatory cytokines release, hepatic ROS production and MDA contents; attenuated hypoxia‐induced decrease of hepatic SOD, CAT, and GSH‐Px activities. Furthermore, salidroside treatment also potentiated the activation of Nrf2‐mediated anti‐oxidant pathway, as indicated by upregulation of n‐Nrf2 and its downstream HO‐1 and NQO‐1. In vitro study found that blocking the Nrf2 pathway using specific inhibitor ML385 significantly reversed the protective effect of salidroside on hypoxia‐induced liver oxidative stress. In addition, salidroside treatment significantly inhibited hepatic pro‐inflammatory cytokines release via JAK2/STAT3‐mediated pathway. Taken together, our findings suggested that salidroside protected against hypoxia‐induced hepatic oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways.