bluuebunny/crossref_metadata_2025_split huggingface dataset:
The incidence and outcome of postoperative hepatic encephalopathy in patients with cirrhosis
Authors: Saleh Zachary M. , Solano Quintin P. , Louissaint Jeremy , Jepsen Peter , Tapper Elliot B. 
Published: June 2021

AbstractBackgroundCirrhosis is associated with increased perioperative risks related to hepatic decompensation. However, data are lacking regarding the incidence and outcomes of postoperative hepatic encephalopathy (HE).ObjectiveTo determine the incidence of HE postoperatively, factors associated with its development, and its association with in‐hospital mortality.MethodsRetrospective cohort study of 583 patients with cirrhosis undergoing non‐hepatic surgery over a 10‐year period. Outcomes included postoperative HE and in‐hospital mortality and were, respectively, evaluated using multi‐state modeling and Fine‐Gray competing risk regression (with postoperative HE as a time‐varying covariate).ResultsOverall, the median Model for End‐Stage Liver Disease Sodium was 10, 61.7% had a history of ascites, 49.9% esophageal varices, and 34.6% HE. The most common surgeries including abdominal/non‐bowel (33.3%), orthopedic (18.0%), and bowel (12.2%). A total of 42 (7.2%) patients developed HE postoperatively during admission. The cumulative risk of HE was 7.2%, which was most associated with a history of HE, ASA class, postoperative AKI, and postoperative infection. In‐hospital mortality occurred in 34 (5.8%) individuals. Only ASA class was independently associated (HR 2.46, 95%CI 1.21–5.02), but there was a trend for postoperative HE (HR 1.71, 95%CI 0.73–3.98).DiscussionHE is an uncommon but not rare postoperative complication that increases the risk of patient harm. This study implies its development is predictable. Consequently, at‐risk patients should have consultation with a hepatologist before undergoing elective surgery.
Semi-supervised Text Mining for Monitoring the News About the ESG Performance of Companies
Authors: Borms Samuel , Boudt Kris , Holle Frederiek Van , Willems Joeri 
Published: June 2021

AbstractWe present a general monitoring methodology to summarize news about predefined entities and topics into tractable time-varying indices. The approach embeds text mining techniques to transform news data into numerical data, which entails the querying and selection of relevant news articles and the construction of frequency- and sentiment-based indicators. Word embeddings are used to achieve maximally informative news selection and scoring. We apply the methodology from the viewpoint of a sustainable asset manager wanting to actively follow news covering environmental, social, and governance (ESG) aspects. In an empirical analysis, using a Dutch-written news corpus, we create news-based ESG signals for a large list of companies and compare these to scores from an external data provider. We find preliminary evidence of abnormal news dynamics leading up to downward score adjustments and of efficient portfolio screening.
Extraction and Representation of Financial Entities from Text
Authors: Repke Tim , Krestel Ralf 
Published: June 2021

AbstractIn our modern society, almost all events, processes, and decisions in a corporation are documented by internal written communication, legal filings, or business and financial news. The valuable knowledge in such collections is not directly accessible by computers as they mostly consist of unstructured text. This chapter provides an overview of corpora commonly used in research and highlights related work and state-of-the-art approaches to extract and represent financial entities and relations.The second part of this chapter considers applications based on knowledge graphs of automatically extracted facts. Traditional information retrieval systems typically require the user to have prior knowledge of the data. Suitable visualization techniques can overcome this requirement and enable users to explore large sets of documents. Furthermore, data mining techniques can be used to enrich or filter knowledge graphs. This information can augment source documents and guide exploration processes. Systems for document exploration are tailored to specific tasks, such as investigative work in audits or legal discovery, monitoring compliance, or providing information in a retrieval system to support decisions.
Supervised Learning for the Prediction of Firm Dynamics
Authors: Bargagli-Stoffi Falco J. , Niederreiter Jan , Riccaboni Massimo 
Published: June 2021

AbstractThanks to the increasing availability of granular, yet high-dimensional, firm level data, machine learning (ML) algorithms have been successfully applied to address multiple research questions related to firm dynamics. Especially supervised learning (SL), the branch of ML dealing with the prediction of labelled outcomes, has been used to better predict firms’ performance. In this chapter, we will illustrate a series of SL approaches to be used for prediction tasks, relevant at different stages of the company life cycle. The stages we will focus on are (1) startup and innovation, (2) growth and performance of companies, and (3) firms’ exit from the market. First, we review SL implementations to predict successful startups and R&D projects. Next, we describe how SL tools can be used to analyze company growth and performance. Finally, we review SL applications to better forecast financial distress and company failure. In the concluding section, we extend the discussion of SL methods in the light of targeted policies, result interpretability, and causality.
Inquiry Systems: How Do We Know What We Need to Know?
Authors: Mitroff Ian I. , Kilmann Ralph H. 
Published: June 2021

AbstractNo less problematic than the various elements we’ve been discussing are the kinds of knowledge that are needed to navigate a complex world of Wicked Messes. As we shall see, it’s not just a matter of Epistemology, i.e., formal theories of knowledge, but how they are affected by and interact with different Psychological states of mind, especially the Parent, Adult, Child, and Secure versus Insecure Adults.
Towards a Standardized Questionnaire for Measuring Agility at Team Level
Authors: Looks Hanna , Fangmann Jannik , Thomaschewski Jörg , Escalona María-José , Schön Eva-Maria 
Published: June 2021

AbstractContext: Twenty years after the publication of the agile manifesto, agility is becoming more and more popular in different contexts. Agile values are changing the way people work together and influence people’s mindset as well as the culture of organizations. Many organizations have understood that continuous improvement is based on measurement.Objective: The objective of this paper is to present how agility can be measured at the team level. For this reason, we will introduce our questionnaire for measuring agility, which is based on the agile values of the manifesto.Method: We developed a questionnaire comprising 36 items that measure the current state of a team’s agility in six dimensions (communicative, change-affine, iterative, self-organized, product-driven and improvement-oriented). This questionnaire has been evaluated with respect to several expert reviews and in a case study.Results: The questionnaire provides a method for measuring the current state of agility, which takes the individual context of the team into account. Furthermore, our research shows, that this technique enables the user to uncover dysfunctionalities in a team.Conclusion: Practitioners and organizations can use our questionnaire to optimize collaboration within their teams in terms of agility. In particular, the value delivery of an organization can be increased by optimizing collaboration at the team level. The development of this questionnaire is a continuous learning process with the aim to develop a standardized questionnaire for measuring agility.
Black holes and the swampland: the deep throat revelations
Authors: Li Yixuan 
Published: June 2021

Abstract
Multi-centered bubbling solutions are black hole microstate geometries that arise as smooth solutions of 5-dimensional $$ \mathcal{N} $$
N
= 2 Supergravity. When these solutions reach the scaling limit, their resulting geometries develop an infinitely deep throat and look arbitrarily close to a black hole geometry. We depict a connection between the scaling limit in the moduli space of Microstate Geometries and the Swampland Distance Conjecture. The naive extension of the Distance Conjecture implies that the distance in moduli space between a reference point and a point approaching the scaling limit is set by the proper length of the throat as it approaches the scaling limit. Independently, we also compute a distance in the moduli space of 3-centre solutions, from the Kähler structure of its phase space using quiver quantum mechanics. We show that the two computations of the distance in moduli space do not agree and comment on the physical implications of this mismatch.
Status and advances in mining for blackleg (Leptosphaeria maculans) quantitative resistance (QR) in oilseed rape (Brassica napus)
Authors: Amas Junrey , Anderson Robyn , Edwards David , Cowling Wallace , Batley Jacqueline 
Published: June 2021

AbstractKey messageQuantitative resistance (QR) loci discovered through genetic and genomic analyses are abundant in theBrassica napusgenome, providing an opportunity for their utilization in enhancing blackleg resistance.AbstractQuantitative resistance (QR) has long been utilized to manage blackleg inBrassica napus(canola, oilseed rape), even before major resistance genes (R-genes) were extensively explored in breeding programmes. In contrast to R-gene-mediated qualitative resistance, QR reduces blackleg symptoms rather than completely eliminating the disease. As a polygenic trait, QR is controlled by numerous genes with modest effects, which exerts less pressure on the pathogen to evolve; hence, its effectiveness is more durable compared to R-gene-mediated resistance. Furthermore, combining QR with major R-genes has been shown to enhance resistance against diseases in important crops, including oilseed rape. For these reasons, there has been a renewed interest among breeders in utilizing QR in crop improvement. However, the mechanisms governing QR are largely unknown, limiting its deployment. Advances in genomics are facilitating the dissection of the genetic and molecular underpinnings of QR, resulting in the discovery of several loci and genes that can be potentially deployed to enhance blackleg resistance. Here, we summarize the efforts undertaken to identify blackleg QR loci in oilseed rape using linkage and association analysis. We update the knowledge on the possible mechanisms governing QR and the advances in searching for the underlying genes. Lastly, we lay out strategies to accelerate the genetic improvement of blackleg QR in oilseed rape using improved phenotyping approaches and genomic prediction tools.
Ordinary varieties with trivial canonical bundle are not uniruled
Authors: Patakfalvi Zsolt , Zdanowicz Maciej 
Published: June 2021

AbstractWe prove that smooth, projective,K-trivial, weakly ordinary varieties over a perfect field of characteristic$$p>0$$p>0are not geometrically uniruled. We also show a singular version of our theorem, which is sharp in multiple aspects. Our work, together with Langer’s results, implies that varieties of the above type have strongly semistable tangent bundles with respect to every polarization.
Playing your pain away: designing a virtual reality physical therapy for children with upper limb motor impairment
Authors: Phelan Ivan , Furness Penny Jayne , Matsangidou Maria , Carrion-Plaza Alicia , Dunn Heather , Dimitri Paul , Lindley Shirley A. 
Published: June 2021

AbstractChildren with upper limb motor impairment often undergo repetitive therapeutic physiotherapy sessions to minimize functional disabilities of the affected area. Even though therapeutic processes can improve functional outcomes and minimize persistent disabilities, patients often neglect to participate fully in physical therapies due to the associated procedural pain. Over recent decades, there has been a growing interest in designing non-pharmacological interventions which aim to minimize pain during physical therapies and improve functional outcomes. Via two interrelated studies, we explored the use of virtual reality (VR) as a tool to provide therapeutic physiotherapy for child patients in an out-patient hospital department. We found that VR is an effective solution for children with upper limb motor impairment undergoing painful therapeutic process within a hospital environment. VR can improve functional disabilities, alleviate perceived pain, reduce the perceived difficulty of rehabilitation exercises, increase exercise duration and produce positive emotions towards the therapy.Trial registration number and date of registration Protocol ID NCT03998995. Release Date: June 25, 2019.
Diagnostic performance of four SARS-CoV-2 antibody assays in patients with COVID-19 or with bacterial and non-SARS-CoV-2 viral respiratory infections
Authors: Huber Timo , Steininger Philipp , Irrgang Pascal , Korn Klaus , Tenbusch Matthias , Diesch Katharina , Achenbach Susanne , Kremer Andreas E. , Werblow Marissa , Vetter Marcel , Bogdan Christian , Held Jürgen 
Published: June 2021

AbstractSARS-CoV-2 antibody assays are used for epidemiological studies and for the assessment of vaccine responses in highly vulnerable patients. So far, data on cross-reactivity of SARS-CoV-2 antibody assays is limited. Here, we compared four enzyme-linked immunosorbent assays (ELISAs; Vircell SARS-CoV-2 IgM/IgA and IgG, Euroimmun SARS-CoV-2 IgA and IgG) for detection of anti-SARS-CoV-2 antibodies in 207 patients with COVID-19, 178 patients with serological evidence of different bacterial infections, 107 patients with confirmed viral respiratory disease, and 80 controls from the pre-COVID-19 era. In COVID-19 patients, the assays showed highest sensitivity in week 3 (Vircell-IgM/A and Euroimmun-IgA: 78.9% each) and after week 7 (Vircell-IgG: 97.9%; Euroimmun-IgG: 92.1%). The antibody indices were higher in patients with fatal disease. In general, IgM/IgA assays had only limited or no benefit over IgG assays. In patients with non-SARS-CoV-2 respiratory infections, IgG assays were more specific than IgM/IgA assays, and bacterial infections were associated with more false-positive results than viral infections. The specificities in bacterial and viral infections were 68.0 and 81.3% (Vircell-IgM/IgA), 84.8 and 96.3% (Euroimmun-IgA), 97.8 and 86.0% (Vircell-IgG), and 97.8 and 99.1% (Euroimmun-IgG), respectively. Sera from patients positive for antibodies against Mycoplasma pneumoniae, Chlamydia psittaci, and Legionella pneumophila yielded particularly high rates of unspecific false-positive results in the IgM/IgA assays, which was revealed by applying a highly specific flow-cytometric assay using HEK 293 T cells expressing the SARS-CoV-2 spike protein. Positive results obtained with anti-SARS-CoV-2 IgM/IgA ELISAs require careful interpretation, especially if there is evidence for prior bacterial respiratory infections.
Maturing Autophagosomes are Transported Towards the Cell Periphery
Authors: Hilverling Anna , Szegö Eva M. , Dinter Elisabeth , Cozma Diana , Saridaki Theodora , Falkenburger Björn H. 
Published: June 2021

AbstractAutophagosome maturation comprises fusion with lysosomes and acidification. It is a critical step in the degradation of cytosolic protein aggregates that characterize many neurodegenerative diseases. In order to better understand this process, we studied intracellular trafficking of autophagosomes and aggregates of α-synuclein, which characterize Parkinson’s disease and other synucleinopathies. The autophagosomal marker LC3 and the aggregation prone A53T mutant of α-synuclein were tagged by fluorescent proteins and expressed in HEK293T cells and primary astrocytes. The subcellular distribution and movement of these vesicle populations were analyzed by (time-lapse) microscopy. Fusion with lysosomes was assayed using the lysosomal marker LAMP1; vesicles with neutral and acidic luminal pH were discriminated using the RFP-GFP “tandem-fluorescence” tag. With respect to vesicle pH, we observed that neutral autophagosomes, marked by LC3 or synuclein, were located more frequently in the cell center, and acidic autophagosomes were observed more frequently in the cell periphery. Acidic autophagosomes were transported towards the cell periphery more often, indicating that acidification occurs in the cell center before transport to the periphery. With respect to autolysosomal fusion, we found that lysosomes preferentially moved towards the cell center, whereas autolysosomes moved towards the cell periphery, suggesting a cycle where lysosomes are generated in the periphery and fuse to autophagosomes in the cell center. Unexpectedly, many acidic autophagosomes were negative for LAMP1, indicating that acidification does not require fusion to lysosomes. Moreover, we found both neutral and acidic vesicles positive for LAMP1, consistent with delayed acidification of the autolysosome lumen. Individual steps of aggregate clearance thus occur in dedicated cellular regions. During aggregate clearance, autophagosomes and autolysosomes form in the center and are transported towards the periphery during maturation. In this process, luminal pH could regulate the direction of vesicle transport.
Graphic Abstract
(1) Transport and location of autophagosomes depend on luminal pH: Acidic autophagosomes are preferentially transported to the cell periphery, causing more acidic autophagosomes in the cell periphery and more neutral autophagosomes at the microtubule organizing center (MTOC). (2) Autolysosomes are transported to the cell periphery and lysosomes to the MTOC, suggesting spatial segregation of lysosome reformation and autolysosome fusion. (3) Synuclein aggregates are preferentially located at the MTOC and synuclein-containing vesicles in the cell periphery, consistent with transport of aggregates to the MTOC for autophagy.
Phase 1a study of the CDK4/6 inhibitor, FCN-437c, in Chinese patients with HR + /HER2- advanced breast cancer
Authors: Zhang Jian , Wang Xiaojia , Wang Xian , Hui Aimin , Wu Zhuli , Tian Ling , Xu Changjiang , Yang Yuchen , Zhang Wenjing , Hu Xichun 
Published: June 2021

Summary Purpose This phase 1a, first-in-human study assessed the safety, maximum tolerated dose (MTD), pharmacokinetics (PK), and antitumor activity of FCN-437c, a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Methods The study enrolled female patients with HR + /HER2- advanced breast cancer (BC) who failed standard of care therapy. A 3 + 3 dose-escalation design was utilized with a starting dose of 50 mg daily for 3 weeks on and 1 week off treatment in 28-day cycles. Patients received escalating doses of FCN-437c monotherapy (50, 100, 200, 300, and 450 mg). Results Seventeen patients received FCN-437c 50 mg (n = 3), 100 mg (n = 3), 200 mg (n = 3), 300 mg (n = 6), and 450 mg (n = 2). Two patients who received the 450-mg dose experienced dose-limiting toxicities (DLTs; grade 4 thrombocytopenia and neutropenia); no DLT was observed at any other dose level. Frequently reported treatment-emergent adverse events (TEAEs) of any grade were hematological: leukopenia (94.1%), neutropenia (88.2%), anemia (64.7%), and thrombocytopenia (47.1%). Grade 3–4 TEAEs included neutropenia (64.7%) and leukopenia (47.1%). Exposure of FCN-437c increased almost proportionally to doses ranging from 50 to 200 mg. At doses from 200 to 450 mg, there appeared to be a trend of saturation. The MTD was determined to be 300 mg. Of 15 patients with measurable disease, nine (60.0%) patients experienced stable disease; no complete or partial responses were observed. Conclusions These results established an acceptable safety profile for FCN-437c in patients with advanced BC, and there were no unexpected signals relative to other CDK4/6 inhibitors. (NCT04488107; July 13, 2020)
Experiences and Perceived Effects of Rosary Praying: A Qualitative Study
Authors: Stöckigt Barbara , Jeserich F. , Walach H. , Elies M. , Brinkhaus B. , Teut M. 
Published: June 2021

AbstractThe aim of this study is to explore experiences and perceived effects of the Rosary on issues around health and well-being, as well as on spirituality and religiosity. A qualitative study was conducted interviewing ten Roman Catholic German adults who regularly practiced the Rosary prayer. As a result of using a tangible prayer cord and from the rhythmic repetition of prayers, the participants described experiencing stability, peace and a contemplative connection with the Divine, with Mary as a guide and mediator before God. Praying the Rosary was described as helpful in coping with critical life events and in fostering an attitude of acceptance, humbleness and devotion.
Effect of mānuka (Leptospermum scoparium) on nitrogen and Escherichia coli reductions in soils: a field experiment
Authors: Halford Sky , Gutiérrez-Ginés María J. , Rees Andrew , Alderton Izzie , Schaller Kolja , Smith Rawiri , Horswell Jacqui 
Published: June 2021

Abstract
Purpose
Planting strategies can be effective mechanisms to reduce diffuse pollution from agricultural catchments reaching water bodies. Plants with antimicrobial properties such as mānuka (Leptospermum scoparium) demonstrated in controlled conditions the ability to inhibit nitrification and growth of pathogens in soils. This potential in a real on-farm setting was still to be investigated.

Methods
In a stock-excluded riparian area, planted with mānuka on a dry stock farm, synthetic excrement patches high in urea (950 kg N ha−1 equiv.) and Escherichia coli (7.9 × 109 cfu plant-1) underneath mānuka saplings and pasture were applied. Soil was sampled at three depths over 21 days after the excrement application and analysed for total C and N, inorganic N, pH, soil moisture and E. coli.

Results
There was no significant difference between the pasture and mānuka for total C and N, C:N ratio, and soil moisture. E. coli was only different between both at 20–30 cm deep. NO3− - N and NH4+ - N concentrations were significantly lower under mānuka compared to pasture for the upper two soil depths (NO3− - N: 109 mg kg−1 vs 205 mg kg−1 in the topsoil).

Conclusions
The results of this study indicate that mānuka may inhibit urease activity and nitrification and could reduce on-farm nitrate leaching, while also highlighting that field conditions make quantifying such phenomenon more complex.
Effect of Jet Vortex Generators on Shock Wave Induced Separation on Gas Turbine Profile
Authors: Flaszynski Pawel , Doerffer Piotr , Piotrowicz Michal 
Published: June 2021

AbstractThe interaction between a shock wave and a boundary layer on a suction side of gas turbine profile, namely Transition Location Effect on Shock Wave Boundary Layer Interaction, was one of main objectives of TFAST project. A generic test section in a transonic wind tunnel was designed to carry out such investigations. The design criteria were to reproduce flow conditions on the profile in wind tunnel as the one existing on the suction side of the turbine guide vane. In this paper, the effect of film cooling and jet vortex generators on the shock wave boundary layer interaction and shock induced separation is presented. Numerical results for Explicit Algebraic Reynolds Stress Model with transition modeling are compared with experimental data.