bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical profiling and multicomponents quantitative analysis of Panzerina lanata by ultra‐fast liquid chromatography with tandem mass spectrometry
Authors: Mi Yingying , Zheng Wei , Zhao Xiangpei , Zhang Xun , Yang Kang , Shen Gangyi , Liu Weizhi , Li Wenrui , Ma Baiping , Zhu Dan 
Published: May 2021

AbstractPanzerina lanata is a Chinese medicine with the bioactivity of detumescence and detoxification. In this study, novel qualitative and quantitative methods were established by ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry and ultra‐high‐performance liquid chromatography‐triple quadrupole linear ion trap mass spectrometry, respectively. As a result, 20 compounds were identified or tentatively characterized including flavonoids, organic acids, alkaloids, and lignans, five of which were identified for the first time based on the reference standards. The quantitative approach exhibited good linearity (R2 > 0.995), precision (RSDs < 4.97%), stability (RSDs < 4.77%), and recovery (96.04‐104.14%). Afterward, this method was implemented to determine 11 flavonoids in four batches of P. lanata. Among them, seven compounds were quantified for the first time. Narcissin was abundant in each batch of P. lanata (average of 10.890‐14.230 mg/g) with the highest quantities. The results provide valuable information for quality evaluation.
Evidence of nitrification associated with globally distributed pelagic jellyfish
Authors: Hubot Nathan D. , Giering Sarah L. C. , Füssel Jessika , Robidart Julie , Birchill Antony , Stinchcombe Mark , Dumousseaud Cynthia , Lucas Cathy H. 
Published: May 2021

AbstractOften considered detrimental to the environment and human activities, jellyfish blooms are increasing in several coastal regions worldwide. Yet, the overall effect of these outbreaks on ecosystem productivity and structure are not fully understood. Here we provide evidence for a so far unanticipated role of jellyfish in marine nitrogen cycling. Pelagic jellyfish release nitrogen as a metabolic waste product in form of ammonium. Yet, we observed high rates of nitrification (NH4+ → NO3−, 5.7–40.8 nM gWW−1 [wet weight] h−1) associated with the scyphomedusae Aurelia aurita, Chrysaora hysoscella, and Chrysaora pacifica and low rates of incomplete nitrification (NH4+ → NO2−, 1.0–2.8 nM gWW−1 h−1) associated with Chrysaora fulgida, C. hysoscella, and C. pacifica. These observations indicate that microbes living in association with these jellyfish thrive by oxidizing the readily available ammonia to nitrite and nitrate. The four studied species have a large geographic distribution and exhibit frequent population outbreaks. We show that, during such outbreaks, jellyfish‐associated release of nitrogen can provide more than 100% of the nitrogen required for primary production. These findings reveal a so far overlooked pathway when assessing pelagic nitrification rates that might be of particular relevance in nitrogen depleted surface waters and at high jellyfish population densities.
Relational interventions for organizational learning: An experience report
Authors: Thygeson N. Marcus , Logan Caroline , Lindberg Curt , Potts Jennifer , Suchman Anthony , Merchant Robert , Thompson Randy 
Published: May 2021

AbstractIntroductionQuality improvement and implementation science practitioners identify relational issues as important obstacles to success. Relational interventions may be important for successful performance improvement and fostering Learning Health Systems.MethodsThis case report describes the experience and lessons learned from implementing a relational approach to organizational change, informed by Relational Coordination Theory, in a health system. Structured interviews were used to obtain qualitative participant feedback. Relational Coordination was measured serially using a validated seven‐item survey.ResultsAn initial, relational intervention on one unit promoted increased participant engagement, self‐efficacy, and motivation that led to the spontaneous, emergent dissemination of relational change, and learning into other parts of the health system. Staff involved in the intervention reported increased systems thinking, enhanced focus on communication and relationships as key drivers for improvement and learning, and greater awareness of organizational change as something co‐created by staff and executives.ConclusionsThis experience supports the hypothesis that relational interventions are important for fostering the development of Learning Health Systems.
Role of Hydrophilic Monomers in α‐Tocopherol‐Based Copolymers in Causing Cell Death by ROS Production
Authors: Kitazume Takuya , Gan Ning , Yusa Shin‐Ichi , Ooya Tooru 
Published: May 2021

Abstractα‐Tocopheryl succinate (TOS) is known to induce cell death by intracellular production of reactive oxygen species (ROS). However, TOS is not enough for cancer target ability. This study is aimed to enhance the accumulation and cytotoxicity of TOS by designing random copolymers. Methacrylated α‐tocopheryl succinate (MTOS) is polymerized with three types of hydrophilic monomers to find appropriate hydrophilic monomer, in terms of particle size, self‐assembled structure, cellular uptake, and cytotoxicity. N‐Vinylpyrrolidone (VP), 2‐methacryloyloxyethyl phosphocholine (MPC), and glycosyloxyethyl methacrylate (GEMA) are selected to prepare the copolymers, and their effect in forming polymeric assembly and cellular uptake are examined. Each hydrophilic monomer is copolymerized with MTOS to obtain random copolymers [poly(GEMA‐ran‐MTOS), poly(VP‐ran‐MTOS), and poly(MPC‐ran‐MTOS)]. The assembled nature is characterized in terms of particle size by dynamic light scattering and transmission electron microscopy: Size of the assembled copolymers increase with the mol% of MTOS. The cytotoxicity of the human cervical cancer cell line (HeLa cells) increases significantly after incubating with poly(GEMA‐ran‐MTOS) and poly(VP‐ran‐MTOS), whereas poly(MPC‐ran‐MTOS) do not affect the cell viability. Both the copolymers enhance the mitochondrial ROS generation in HeLa cells. Therefore, choice of hydrophilic monomers to copolymerize with MTOS dominates to enhance the accumulation and cytotoxicity of TOS.
High‐Temperature Bearable Polysulfonamide/Polyurethane Composite Nanofibers’ Membranes for Filtration Application
Authors: Li Yajian , Ming Jinfa , Yuan Ding , Ning Xin 
Published: May 2021

AbstractPolysulfonamide (PSA)‐based membranes are widely used for high‐temperature filtration. PSA/polyurethane (TPU) composite membranes that can withstand a temperature exceeding 200 °C are fabricated by an electrospinning method. The effects of PSA/TPU mass ratio on the morphology and properties of the prepared composite membranes are investigated to obtain nanofibers with different diameters. These composite membranes are characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR), and differential scanning calorimetry, and mechanical and filtration properties of membranes are also investigated. The maximum stress and elongation at break of PSA/TPU nanofibers’ membranes reach 13.66 ±1.43 MPa and 75.01 ± 3.78%, respectively, when the PSA/TPU mass ratio is 3:7. Moreover, filtration results show high filtration efficiency (>99%) and low pressure drop for diethyl‐hexyl‐sebacat (DEHS) and sodium chloride (NaCl) aerosol particles at 4 m3 h−1 airflow velocity. Therefore, PSA/TPU composite membranes are a promising candidate for high‐temperature filtration applications.
Holomorphic functions with large cluster sets
Authors: Alves Thiago R. , Carando Daniel 
Published: May 2021

AbstractWe study linear and algebraic structures in sets of bounded holomorphic functions on the ball which have large cluster sets at every possible point (i.e., every point on the sphere in several complex variables and every point of the closed unit ball of the bidual in the infinite dimensional case). We show that this set is strongly ‐algebrable for all separable Banach spaces. For specific spaces including or duals of Lorentz sequence spaces, we have strongly ‐algebrability and spaceability even for the subalgebra of uniformly continous holomorphic functions on the ball.
Blending as a Strategy to Attain Chiro‐Optically Activity Polymers
Authors: Glislere Ana Paula , Turchetti Denis , Nowacki Bruno , Zanlorenzi Cristiano , Akcelrud Leni 
Published: May 2021

AbstractTwo copolymers, one containing a chiral center and another without any asymmetric site are studied regarding their chiro‐optical properties. The pure polymers do not show any signal of chiro‐optical activity, only a smooth line is observed in the circular dichroism spectra, even for the chiral material. However, blends containing the achiral one as a major component show striking chiro‐optical activity, originating by stable supramolecular structures whose size and shape remain unchanged, regardless of the blend composition. Only the number of such structures (composed by the chiral one), vary with blend composition. The results suggest that working with supramolecular morphology can be an important strategy to attain chiro‐optical active polymers.
Disposition of Dietary Polyphenols in Breast Cancer Patients’ Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin
Authors: Ávila‐Gálvez María Ángeles , González‐Sarrías Antonio , Martínez‐Díaz Francisco , Abellán Beatriz , Martínez‐Torrano Alejandro José , Fernández‐López Antonio José , Giménez‐Bastida Juan Antonio , Espín Juan Carlos 
Published: May 2021

ScopeSome polyphenol‐derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) and malignant (MT) mammary tissues of newly‐diagnosed BC patients and the tissue‐occurring metabolites’ anticancer activity are evaluated.Methods and resultsPatients (n = 26) consumed 3 capsules/day (turmeric, red clover, and flaxseed extracts plus resveratrol; 296.4 mg phenolics/capsule) from biopsy‐confirmed diagnosis to surgery (5 ± 2 days) or did not consume capsules (n = 13). NT and MT, blood, and urine are analyzed by UPLC‐QTOF‐MS using targeted metabolomics. Anticancer activity was tested in MCF‐7 and MDA‐MB‐231 BC cells. Mainly phase‐II metabolites were detected (108, 84, 49, and 47 in urine, plasma, NT, and MT, respectively). Total metabolite concentrations reached 10.7 ± 11.1 and 2.5 ± 2.4 µmol L–1 in NT and MT, respectively. Free curcumin, but not its glucuronide, was detected in the tissues (1.1 ± 1.8 and 0.2 ± 0.2 µmol L–1 in NT and MT, respectively). Breast tissue‐occurring metabolites’ antiproliferation was mainly exerted in p53‐wild‐type MCF‐7 cells by curcuminoids through cell cycle arrest, senescence, and apoptosis induction via p53/p21 induction, while isoflavone‐derived metabolites exerted estrogenic‐like activity.ConclusionCurcuminoids could be coadjuvants that might help fight BC upon regular consumption.
Display Week Provides Sustenance for the Body and Mind
Authors: Atwood Stephen P. 
Published: May 2021

AbstractI miss restaurants and the incredible variety of places available to indulge in all manner of tastes and the shared experiences to energize me at the same time. Going to California a couple of times each year for Display Week activities was always a highlight of my year. First, we'd gather in January for the technical program committee meetings and then again in May for the main event. I'd see people I truly admire but only get to talk with a few times a year—people who would help me feel re‐energized with their incredible work and personal stories.
Toward “Light‐to‐Light” Protection of Automotive Camera Monitor Systems
Authors: Axmann Benjamin , Langner Frank , Xu Chihao , Blankenbach Karlheinz , Conrad Mirko , Bauer Jan 
Published: May 2021

AbstractThe use of CMS to replace rear‐ and side‐view mirror functions in cars is gaining traction. However, implementing these systems safely requires a high level of performance monitoring to ensure that they work properly. The authors describe new methods toward full end‐to‐end or “light‐to‐light” performance monitoring.
„Die Angewandte ist etwas Besonderes“
Authors: Landfester Katharina , Remenyi Christian 
Published: May 2021

AbstractDie Polymerchemikerin Katharina Landfester ordnet im Angewandte Council die Steuerungsgremien der Zeitschrift Angewandte Chemie neu. Die Nachrichten aus der Chemie sprachen mit ihr über Monster‐Impact‐Faktoren und warum Editoren aus der Wissenschaft einem Fachjournal gut tun.
Computer statt Kolben
Authors: Tratter Anna 
Published: May 2021

AbstractSie arbeiten mit Forschungsergebnissen, ohne das Labor von innen zu sehen – Chemiker:innen in Wissenschaftsverlagen. Sie prüfen Manuskripte, suchen Gutachter, arbeiten mit Datenbanken oder optimieren ihr Produkt: die Wissensvermittlung.
Phthalocyanin‐Synthese: vom Ursprung zu aktuellen Trends
Authors: Galstyan Anzhela 
Published: May 2021

AbstractPhthalocyanine wurden in Schottland zufällig vor mehr als 90 Jahren bei einem industriellen Prozess entdeckt. Heute sind die Makrocyclen mit alternierender Stickstoff‐Kohlenstoff‐Ringstruktur nicht nur selektiv herstellbar, sondern auch ihre Eigenschaften lassen sich einstellen.
Verlagswesen: Von Büchern und Zeitschriften
Authors: Bulmahn Maren 
Published: May 2021

AbstractUnter den nach Umsatz 15 größten deutschsprachigen Verlagen sind einige Fachinformationsverlage. Internationale Wissenschaftsverlage wie Elsevier, Springer Nature und Wiley setzen jeweils mehr um. Besonders gut verkauften sich im vergangenen Jahr aber Kinderbücher.
Anticipated nursing care as perceived by nursing students: Findings from a qualitative study
Authors: Lunardelli Lisa , Danielis Matteo , Bottega Michela , Palese Alvisa 
Published: May 2021

AbstractAimTo explore the perceptions of nursing students on the phenomenon of anticipated nursing care.DesignA descriptive‐qualitative study was performed in 2019 according to the Consolidated Criteria for Reporting Qualitative Research principles.MethodsData were collected using 16 face‐to‐face, audio‐recorded interviews across four Italian Bachelor of Nursing degrees. Then, content analysis was performed, identifying, analysing and describing the anticipated nursing care phenomenon as perceived by nursing students.ResultsAdministering medications, providing fundamentals of care, managing some clinical procedures, freeing up the patient's bed and starting the shifts early emerged as the most anticipated nursing interventions. Stable, older patients who were more functionally dependent were reported to receive some fundamental nursing care before the expected time, while older, stable and more independent patients were used to receiving medications in advance. Anticipated nursing care is triggered by factors at the time management, resource, programming, professional and organizational levels.
Health literacy and its relation to continuing with breastfeeding at six months post‐partum in a sample of Spanish women
Authors: Valero‐Chillerón María Jesús , González‐Chordà Victor M. , Cervera‐Gasch Águeda , Vila‐Candel Rafael , Soriano‐Vidal Francisco Javier , Mena‐Tudela Desirée 
Published: May 2021

AbstractAimTo explore the relation between health literacy (HL) and continuing breastfeeding (BF) at 6 months post‐partum.DesignObservational, longitudinal and prospective study between December 2018–May 2019. The STROBE checklist was used.Methods114 mother/baby pairings from a Spanish Hospital were included. Mothers’ health literacy was studied with the Newest Vital Sign and Short Assessment of Health Literacy for Spanish Adults 50 (SAHLSA‐50). Before hospital discharge, BF efficiency was studied using the LATCH BF score and BF continuity was followed for 6 months. Survival analysis and Cox regression were done.ResultsHealth literacy levels and BF effectiveness were adequate before hospital discharge. At 6 months post‐partum, less than half the sample still exclusively breastfed. The main reason for early exclusive BF cessation was lower than the recommended newborn weight gain. The HL level acted as a protective factor against abandonment of BF.
Health promotion behaviours of pregnant women and spiritual well‐being: Mediatory role of pregnancy stress, anxiety and coping ways
Authors: Chehrazi Mohammad , Faramarzi Mahbobeh , Abdollahi Somayeh , Esfandiari Maria , Shafie rizi Shiva 
Published: May 2021

AbstractAimLittle is known about the link between spiritual well‐being and health promotion behaviours in pregnant women. The study aimed to explore the direct and indirect effects of spirituality on health promotion behaviours with the mediatory roles of pregnancy stress, anxiety and coping ways.DesignCross‐sectional.MethodsTwo hundred women aged above 18 years completed Spiritual Well‐Being scale (SWBS), State‐Anxiety Inventory (SAI), Promoting Lifestyle Profile (HPLP), Prenatal Coping Inventory (Nu‐PCI) and Revised Prenatal Distress Questionnaire (NuPDQ).ResultsSpirituality directly and negatively affected the state anxiety (β = −.41; p < .001) and NuPDQ (β = −.36; p < .001). Health promotion behaviours were negatively related to state anxiety (β = −.36; p < .001) and positively to planning‐preparation coping (β = .23; p = .001). Spirituality had a significant indirect effect on health promotion behaviours (β = .33; p < .001), mediated through its association with state anxiety and planning‐preparation coping. Thus, health professionals are proposed to consult pregnant women on the benefits of spirituality for improving healthy behaviours.
Metabolic Characterization of Meat, Fish, and Soda Intake in Males: Secondary Results from a Randomized Inpatient Pilot Study
Authors: Mitchell Cassie M. , Piaggi Paolo , O’Brien Diane M. , Krakoff Jonathan , Votruba Susanne B. 
Published: May 2021

ObjectiveThis study aimed to evaluate whether a 12‐week, weight‐maintaining, macronutrient‐stable dietary intervention that varies only by meat, fish, or soda consumption alters 24‐hour energy expenditure (24hrEE) and substrate oxidation.MethodsHealthy males were recruited to participate in a 12‐week inpatient study and were randomized to a weight‐maintaining dietary intervention that contained varying combinations of meat (0% or 19%), fish (0% or 6%), or soda (0% or 14%) in a factorial design. Macronutrient composition across dietary intervention groups was as follows: 50% of energy from carbohydrates, 30% of energy from fat, and 20% of energy from protein. Whole‐room indirect calorimetry at baseline and week 12 were used to measure 24hrEE and substrate oxidation.ResultsTwenty‐six males (mean [SEM], age: 46.6 [10.4] years; BMI: 26.9 [4.1] kg/m2) completed all measurements. Fish consumption resulted in higher 24hrEE by 126 (55) kcal/d compared with no fish consumption (P = 0.03), whereas 24hrEE for soda consumption was 132 (56) kcal/d (P = 0.03) lower. Approximately 80% of the decrease in 24hrEE with soda consumption was due to lower awake‐inactive energy expenditure (EE; P = 0.001). No specific EE component accounted for the differences observed with fish consumption.ConclusionsThe data indicate that dietary sources of protein and carbohydrates appear to influence 24hrEE and inactive EE.
Impact of adherence to drugs for secondary prevention on mortality and cardiovascular morbidity: A population‐based cohort study. IMPACT study
Authors: Sotorra‐Figuerola Gerard , Ouchi Dan , Giner‐Soriano Maria , Morros Rosa 
Published: May 2021

AbstractPurposeAdherence to pharmacological therapy for secondary prevention after an acute coronary syndrome (ACS) reduces the risk of new cardiovascular events. However, several studies showed poor adherence. Our study aim was to assess the risk of a composite endpoint of major cardiovascular events (MACE) and all‐cause mortality according to the adherence to these drugs in patients after an ACS in a primary health care cohort.MethodsPopulation‐based observational cohort study of patients with a first episode of ACS during 2009–2016. Data source: Information System for Research in Primary Care (SIDIAP) database. Drug adherence was evaluated through proportion of days covered (PDC).ResultsWe included 7152 patients and 5692 (79.6%) were adherent (PDC ≥ 75%) to the study drugs during the first year after the event. Adherents to any combination showed a significant reduction of the composite endpoint risk (HR 0.80 [0.73–0.88]), and a significant lower probability of the composite endpoint than nonadherents for all drugs, except beta‐blockers. Adherents to 2 (HR 1.2; 95% CI 1.0–1.3) and 1 drug (HR 1.5; 95% CI 1.2–1.8) had higher composite endpoint risk compared to adherents to 4–3 drugs.ConclusionAdherence to any combination of recommended drugs reduced the composite endpoint risk, regardless the number of drugs prescribed. Adherence to a combination of 4–3 drugs was significantly associated with a reduced mortality risk compared with adherents to 2 or 1, but it was not significant for MACE.
Monitoring of nonthermal plasma degradation of phthalates by ion mobility spectrometry
Authors: Moravský Ladislav , Michalczuk Bartosz , Hrdá Jana , Hamaguchi Satoshi , Matejčík Štefan 
Published: May 2021

AbstractIon mobility spectrometry was used to monitor the degradation of phthalate vapors by corona discharge. Three different phthalates (dimethyl [DMP], diethyl [DEP], and dipropyl [DPP]) were examined in a corona discharge reactor (wire‐to‐cylinder geometry) at direct current positive polarity in ambient air. The relative removal efficiencies up to 96% and energetical degradation efficiencies of 229.27, 216.12, and 198.84 kJ mg−1 were achieved for DMP, DEP, and DPP, respectively. Byproducts such as methanol, ethanol, and 1‐ and 2‐propanol at extremely low densities were also detected. The identified degradation processes involved two steps: (i) An electron‐impact dissociation of phthalates into alkoxyl radicals and (ii) reactions of alkoxy radicals with water molecules to form alcohols.
Protein folding ‐ seeing is deceiving
Authors: Rose George D. 
Published: May 2021

AbstractThis Perspective is intended to raise questions about the conventional interpretation of protein folding. According to the conventional interpretation, developed over many decades, a protein population can visit a vast number of conformations under unfolding conditions, but a single dominant native population emerges under folding conditions. Accordingly, folding comes with a substantial loss of conformational entropy. How is this price paid? The conventional answer is that favorable interactions between and among the side chains can compensate for entropy loss, and moreover, these interactions are responsible for the structural particulars of the native conformation. Challenging this interpretation, the Perspective introduces a proposal that high energy (i.e., unfavorable) excluding interactions winnow the accessible population substantially under physical–chemical conditions that favor folding. Both steric clash and unsatisfied hydrogen bond donors and acceptors are classified as excluding interactions, so called because conformers with such disfavored interactions will be largely excluded from the thermodynamic population. Both excluding interactions and solvent factors that induce compactness are somewhat nonspecific, yet together they promote substantial chain organization. Moreover, proteins are built on a backbone scaffold consisting of α‐helices and strands of β‐sheet, where the number of hydrogen bond donors and acceptors is exactly balanced. These repetitive secondary structural elements are the only two conformers that can be both completely hydrogen‐bond satisfied and extended indefinitely without encountering a steric clash. Consequently, the number of fundamental folds is limited to no more than ~10,000 for a protein domain. Once excluding interactions are taken into account, the issue of “frustration” is largely eliminated and the Levinthal paradox is resolved. Putting the “bottom line” at the top: it is likely that hydrogen‐bond satisfaction represents a largely under‐appreciated parameter in protein folding models.