bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrapartum Epidural Analgesia and Low Apgar Score Among Singleton Infants Born at Term: A Propensity Score Matched Study
Authors: Ravelli A.C.J. , Abu-Hanna A. , Eskes M. , de Groot C.J.M. , van der Post J.A.M. 
Published: May 2021

(Acta Obstet Gynecol Scand. 2020;99:1155–1162)
While the infant mortality in at-term births is low in Western countries, a recent trend has developed wherein birth asphyxia (based on low Apgar score) is the leading cause of death in term infants in the Netherlands who were admitted to a neonatal intensive care unit (NICU). Therefore, additional attention should be given to term neonates with low Apgar scores, and research on NICU admission should be emphasized as part of the assessment of perinatal health in this group of patients. The underlying risks for asphyxia include hypertensive disorders, maternal diabetes (both preexisting and gestational), non-cephalic presentation at birth, prolonged second stage of labor, and intrapartum epidural analgesia (EA). As EA is not generally used in the Netherlands, although its popularity has slowly increased in recent years, this environment is ideal for analyzing the effects of EA on full-term infants. This study aimed to assess the effects of EA on low Apgar score and subsequent NICU admission in term, singleton births and to analyze other underlying risk factors.
Subcutaneous Buprenorphine Extended-Release Use Among Pregnant and Postpartum Women
Authors: Cleary E.M. , Byron R.K. , Hinely K.A. , Talley A.W. , Costantine M.M. , Rood K.M. 
Published: May 2021

(Obstet Gynecol. 2020;136:902–903)
Sublingual buprenorphine is used to treat moderate-to-severe opioid-use disorder (OUD) in pregnant and lactating women. Its advantages over methadone are fewer cardiac arrhythmias, fewer death due to overdose, and less severe withdrawal symptoms from opioids in neonates. Extended-release buprenorphine has recently been approved by the U.S. Food and Drug Administration for OUD treatment in nonpregnant women, who have been stable on daily sublingual buprenorphine. However, data on its use in pregnant and lactating women is unknown since this population was not included in Phase 1 through Phase 3 trials. The aim of this study was to assess the use of extended-release buprenorphine for the treatment of OUD in pregnant and lactating women.
A Randomized Controlled Trial of Liposomal Bupivacaine for Pain Following Obstetrical Laceration
Authors: Dengler K.L. , Simpson K.J. , Strauchon C.J. , Shaddeau A.K. , Brooks D.I. , Gruber D.D. 
Published: May 2021

(Am J Obstet Gynecol MFM. 2020;2:100115)
Following a second-, third-, or fourth-degree laceration in a vaginal delivery, pain management is important. Correct pain management methods can positively impact the postpartum recovery period and the desire to decrease use of opioids has led to the search for long-acting non-opioid medications. Liposomal bupivacaine is bound by liposomes, allowing for a slow release of bupivacaine (and therefore prolonged analgesia). While studies exist referencing the effectiveness of bupivacaine as a postoperative pain management treatment, its use as a treatment following lacerations after vaginal delivery have yet to be documented. The primary aim of this study was to assess the effectiveness of liposomal bupivacaine as a pain control method following vaginal deliveries involving a second-, third-, or fourth-degree obstetric laceration on postpartum day (PPD) 3.
Cervical Dilation at the Time of Epidural Catheter Insertion Is Not Associated With the Degree of Prolongation of the First or Second Stages of Labor, or the Rate of Instrumental Vaginal Delivery
Authors: Lipschuetz M. , Nir E.A. , Cohen S.M. , Guedalia J. , Hochler H. , Amsalem H. , Karavani G. 
Published: May 2021

(Acta Obstet Gynecol Scand. 2020;99:1039–1049)
Although epidural analgesia (EA) is used in over 60% of deliveries in Western countries with high patient satisfaction, it has been associated with risk of prolonged second stage of labor and instrumental vaginal delivery. The optimal time to administer EA based on cervical dilation is unknown, and whether the timing of its administration affects the duration of the first and second stages of labor or maternal or fetal outcomes. The aim of this study was to determine if the cervical dilation at the time of epidural placement impacts the duration of the first and/or second stage of labor and correlates with the rate of instrumental vaginal delivery.
Impact of Anesthesiologist’s Fellowship Status on the Risk of General Anesthesia for Unplanned Cesarean Delivery
Authors: Wagner J.L. , White R.S. , Mauer E.A. , Pryor K.O. , Kjaer K. 
Published: May 2021

(Acta Anaesthesiol Scand. 2019;63:769–774)
The use of general anesthesia (GA) in unplanned cesarean delivery (CD) is associated with risks including difficult airway management and fetal depression, while neuraxial anesthesia for cesarean is associated with more successful breastfeeding and decreased use of opioids. While it is recommended to keep the rate of GA use below 3% for unplanned cesarean patients receiving epidural labor analgesia (ELA), GA is used in 5% of these cases (ELA-GA). Care provided by a non-obstetric anesthesiologist is one possible, modifiable risk factor for ELA-GA. This retrospective study aimed to investigate the effect of training in obstetric anesthesia as a risk factor for GA use in ELA-CD patients.
Choice of Hypnotic Drug for Obstetric and Non-obstetric General Anaesthesia. Comment on Br J Anaesth 2020; 125: e81-7
Authors: Bouvet L. , Chassard D. 
Published: May 2021

(Br J Anaesth. 2020;125:e452–e453)
Airway management conditions are affected by many factors, including the anesthetic induction drugs used. A recent study by Bonnett and colleagues in patients undergoing non-elective Cesarean delivery found co-administering propofol with succinylcholine resulted in superior intubating conditions compared with the co-administration of thiopental with succinylcholine. These results support the use of propofol rather than thiopental in obstetric general anesthesia.
Impact of an Enhanced Recovery Program for Cesarean Delivery on Postoperative Opioid Use
Authors: Lester S.A. , Kim B. , Tubinis M.D. , Morgan C.J. , Powella M.F. 
Published: May 2021

(Int J Obstet Anesthesia. 2020;43:47–55)
Enhanced recovery programs have been increasingly used following cesarean delivery (CD). In other settings, enhanced recovery after surgery programs have been shown to speed recovery and decrease the postoperative use of opioids. This study aimed to determine whether postoperative opioid consumption would be reduced in CD patients receiving an enhanced recovery program.
Janus kinase–signal transducers and activators of transcription cell signaling in Spondyloarthritis: rationale and evidence for JAK inhibition
Authors: Raychaudhuri Suravi , Cheema Karmtej Singh , Raychaudhuri Smriti K. , Raychaudhuri Siba P. 
Published: May 2021

Purpose of review
The Janus kinase–signal transducers and activators of transcription (JAK–STAT) signaling proteins represent a group of intracellular kinase molecules that play a central role in the signaling pathways induced by cytokines, chemokines, and certain growth factors associated with systemic and local inflammation of autoimmune diseases including in Spondyloarthritis (SpA). Here, we will discuss (i) the functional significance of the JAK–STAT kinase cascades in the inflammatory-proliferative processes of SpA and its cellular/molecular mechanisms (ii) progress in the development of oral synthetic JAK inhibitors (JAKi) and their therapeutic efficacies in SpA.

Recent findings
Development JAKi is a fast-moving field in the medical science. Several new-generation JAKi are being identified for psoriatic arthritis and ankylosing spondylitis. It is expected these JAKi likely to have higher potency and less adverse effects.

Summary
Here, we are providing an updated review on the significance of JAK–STAT signaling proteins in SpA with an emphasis on new-generation of JAK–STAT inhibitors for the treatment of SpA.
RBC Transfusion Induced ST Segment Variability Following the Norwood Procedure
Authors: Savorgnan Fabio , Bhat Priya N. , Checchia Paul A. , Acosta Sebastian , Tume Sebastian C. , Lasa Javier J. , Asadourian Vicken , Achuff Barbara-Jo , Flores Saul , Ahmed Mubasheer , Crouthamel Daniel I. , Loomba Rohit S. , Bronicki Ronald A. 
Published: May 2021

Objectives:
The transfusion of stored RBCs decreases nitric oxide bioavailability, which may have an adverse effect on vascular function. We assessed the effects of RBC transfusion on coronary vascular function by evaluating the relationship between myocardial oxygen delivery and demand as evidenced by ST segment variability.

Design:
Retrospective case-control study.

Setting:
Nine-hundred seventy-three–bed pediatric hospital with a 54-bed cardiovascular ICU.

Patients:
Seventy-three neonates with hypoplastic left heart syndrome following the Norwood procedure, 38 with a Blalock-Taussig shunt and 35 with a right ventricle to pulmonary artery shunt.

Interventions:
RBC transfusion.

Materials and Main Results:
High-frequency physiologic data were captured 30 minutes prior to the initiation of (baseline) and during the 120 minutes of the transfusion. A rate pressure product was calculated for each subject and used as an indicator of myocardial oxygen demand. Electrocardiogram leads (aVL, V1, II) were used to construct a 3D ST segment vector to assess ST segment variability and functioned as a surrogate indicator of myocardial ischemia. One-hundred thirty-eight transfusions occurred in the Blalock-Taussig shunt group and 139 in the right ventricle to pulmonary artery shunt group. There was no significant change in the rate pressure product for either group; however, ST segment variability progressively increased for the entire cohort during the transfusion, becoming statistically significant by the end of the transfusion. Upon subgroup analysis, this finding was noted with statistical significance in the Blalock-Taussig shunt group and trending toward significance in the right ventricle to pulmonary artery shunt group.

Conclusions:
We found a significant increase in the ST segment variability and evidence of myocardial ischemia temporally associated with RBC transfusions in neonates following the Norwood procedure, specifically among those in the Blalock-Taussig shunt group, which may impact immediate and long-term outcomes.
The Effects of Focal Electrically Administered Seizure Therapy Compared With Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy on Suicidal Ideation
Authors: Youssef Nagy A. , George Mark S. , McCall William V. , Sahlem Gregory L. , Short Baron , Kerns Suzanne , Manett Andrew J. , Fox James B. , Dancy Morgan , Cook Daniel , Devries William , Rosenquist Peter B. , Sackeim Harold A. 
Published: May 2021

Background
Preliminary data suggest that focal electrically administered seizure therapy (FEAST) has antidepressant effects and less adverse cognitive effects than traditional forms of electroconvulsive therapy (ECT). This study compared the impact of FEAST and ultrabrief pulse, right unilateral (UB-RUL) ECT on suicidal ideation.

Methods
At 2 sites, patients in a major depressive episode were treated openly with FEAST or UB-RUL ECT, depending on their preference. The primary outcome measure was scores on the Beck Scale for Suicide Ideation (SSI). Scores on the suicide item of the Hamilton Rating Scale for Depression (HRSD-SI) provided a secondary outcome measure.

Results
Thirty-nine patients were included in the intent-to-treat sample (FEAST, n = 20; UB-RUL ECT, n = 19). Scores on both the SSI and HRSD-SI were equivalently reduced with both interventions. Both responders and nonresponders to the interventions showed substantial reductions in SSI and HRSD-SI scores, although the magnitude of improvement was greater among treatment responders.

Conclusions
Although limited by the open-label, nonrandomized design, FEAST showed comparable effects on suicidal ideation when compared with routine use of UB-RUL ECT. These results are encouraging and support the need for further research and a noninferiority trial.
Pre-Clinical Application of Functional Human Induced Pluripotent Stem Cell-Derived Airway Epithelial Grafts
Authors: Varma Ratna , Marin-Araujo Alba E. , Rostami Sara , Waddell Thomas K. , Karoubi Golnaz , Haykal Siba 
Published: May 2021

AbstractAirway pathologies including cancer, trauma and stenosis lack effective treatments, meanwhile airway transplantation and available tissue engineering approaches fail due to epithelial dysfunction. Autologous progenitors do not meet the clinical need for regeneration due to their insufficient expansion and differentiation, for which human induced pluripotent stem cells (hiPSCs) are promising alternatives. Airway epithelial grafts are engineered by differentiating hiPSC-derived airway progenitors into physiological proportions of ciliated (73.9±5.5%) and goblet (2.1±1.4%) cells on a Silk Fibroin-Collagen Vitrigel Membrane (SF-CVM) composite biomaterial for transplantation in porcine tracheal defectsex vivoandin vivo. Evaluation ofex vivotracheal repair using hiPSC-derived SF-CVM grafts demonstrate native-like tracheal epithelial metabolism and maintenance of mucociliary epithelium to day 3.In vivostudies reveal SF-CVM integration, maintenance of airway patency, showing 80.8±3.6% graft coverage with an hiPSC-derived pseudostratified epithelium and 70.7±2.3% coverage with viable cells, 3 days post-operatively. We demonstrate the utility of bioengineered, hiPSC-derived epithelial grafts for airway repair in a pre-clinical survival model, providing a significant leap for airway reconstruction approaches.
Effect of reduced graphene oxide (rGO) compaction degree and concentration on rGO-polymer composites printability and cell interactions
Authors: Cámara-Torres María , Sinha Ravi , Eqtesadi Siamak , Wendelbo Rune , Scatto Marco , Scopece Paolo , Sanchez Alberto , Villanueva Sara , Egizabal Ainhoa , Álvarez Noelia , Patelli Alessandro , Mota Carlos , Moroni Lorenzo 
Published: May 2021

AbstractGraphene derivatives combined with polymers have attracted enormous attention for bone tissue engineering applications. Among others, reduced graphene oxide (rGO) is one of the preferred graphene-based fillers for the preparation of composites via melt compounding, and their further processing into 3D scaffolds, due to its established large-scale production method, thermal stability, and electrical conductivity. In this study, rGO (low bulk density 10g/L) was compacted by densification using a solvent (either acetone or water) prior to melt compounding, to simplify its handling and dosing into a twin-screw extrusion system. The effects of rGO bulk density (medium and high), densification solvent, and rGO concentration (3, 10 and 15% in weight) on rGO dispersion within the composite, electrical conductivity, printability and cell-material interactions were studied. High bulk density rGO (90 g/L) occupied a low volume fraction within polymer composites, offering poor electrical properties but a reproducible printability up to 15 wt% rGO. On the other hand, the volume fraction within the composites of medium bulk density rGO (50 g/L) was higher for a given concentration, enhancing rGO particle interactions and leading to enhanced electrical conductivity, but compromising the printability window. For a given bulk density (50 g/L), rGO densified in water was more compacted and offered poorer dispersability within the polymer than rGO densified in acetone, and resulted in scaffolds with poor layer bonding or even lack of printability at high rGO percentages. A balance in printability and electrical properties was obtained for composites with medium bulk density rGO densified in acetone. Here, increasing rGO concentration led to more hydrophilic composites with a noticeable increase in protein adsorption. Moreover, scaffolds prepared with such composites presented antimicrobial properties even at low rGO contents (3 wt%). In addition, the viability and proliferation of human mesenchymal stromal cells (hMSCs) was maintained on scaffolds with up to 15% rGO and with enhanced osteogenic differentiation on 3% rGO scaffolds.
Phospholipases D1 and D2 regulate cell cycling in primary prostate cancer cells and are differentially associated with the nuclear matrix
Authors: Noble Amanda R , Hogg Karen , Bourgoin Sylvain , Coverley Dawn , Archer Leanne , Frame Fiona , Maitland Norman J , Rumsby Martin G 
Published: May 2021

AbstractPhospholipases D1 and D2 (PLD1/2) have been implicated in tumorigenesis. We previously detected higher expression of PLD in the nuclei of patient-derived prostate cancer (PCa) cells and prostate cancer cell lines. Here we have examined whether PLD1 or PLD2 are associated with the nuclear matrix and influence cell cycling. PLD1/PLD2 were detected by qualitative immunofluorescence in cultured PCa cells and extracted with a standardised protocol to reveal nuclear matrix-associated proteins. The effects of isoform-specific inhibition of PLD1or PLD2 on PCa cell cycle progression were analysed by flow cytometry. PLD2 mainly co-localised with the nucleolar marker fibrillarin in PCa cells. However, even after complete extraction, some PLD2 remained associated with the nuclear matrix. Inhibiting PLD2 effectively reduced PCa cell cycling into and through S phase. In contrast, PLD1 inhibition effects were weaker, and a subpopulation of cycling patient-derived PCa cells was unaffected by PLD1 inhibition. When associated with the nuclear matrix PLD2 could generate phosphatidic acid to regulate nuclear mTOR and control downstream transcriptional events. The association of PLD2 with the nucleolus also implies a role in stress regulation. The cell cycling results highlight the importance of PLD2 inhibition as a novel potential prostate cancer therapeutic mechanism by differential regulation of cell proliferation.
Coping with the COVID-19 pandemic: the technical, moral and facilitating role of management control
Authors: Passetti Emilio Emilio , Battaglia Massimo , Bianchi Lara , Annesi Nora 
Published: May 2021

PurposeThe study analyses how management control supports the organisation's response to the COVID-19 pandemic lockdown.Design/methodology/approachVideo interviews with top and middle-level managers who were directly involved in handling the response to the COVID-19 crisis in late winter and spring 2020 form the empirical base. The object-of-control framework and the distinction between organic and mechanistic management controls inform the exploratory case analysis of a large food retail cooperative in Italy.FindingsBoth organic and mechanistic management control mechanisms enabled an immediate response and management of the crisis. The use of cultural, action and results controls supported employees' health and safety coordination, a tight monitoring of financial performance and social interventions in support of the local community.Originality/valueThe study provides original exploratory insights on the use and role of management control in the context of an unprecedented emergency and an unplanned setting (i.e. a pandemic crisis), which is an under-investigated topic in the accounting literature. The study shows how management control operated, linking moral and technical aspects as well as facilitating organisational adaptation and pandemic effects mitigation.
Producers' and processors' perceptions of locality and its interaction with the concept of organic farming – empirical evidence from Denmark
Authors: Teuber Ramona , Jensen Jørgen Dejgård 
Published: May 2021

PurposeGiven the fact that local food as a tool to create value-added is a relatively new trend in Scandinavian countries with a strong emphasis on organic food, only limited – and mainly qualitative and case-based - empirical evidence on producers and processors involved in local food value chains (FVCs) has been available so far. Thus, the present paper contributes to the small but growing literature analyzing local FVCs by providing and analyzing quantitative survey data. More specifically, the authors aim at investigating (1) how agricultural producers and processors define and perceive local food, (2) which drivers are important for the decision to become involved in local FVC and (3) whether these drivers differ in a systematic way across producers and processors.Design/methodology/approachIn order to address these research questions, empirical data from a quantitative stakeholder survey carried out in spring in 2017 is used. Data are analyzed via descriptive and inductive statistics including a cluster analysis.FindingsThe survey results concerning the definition and perceptions of local food are in line with previous studies showing that there is usually a strong emphasis on geographic proximity. Besides, local (organic) food producers and processors are diverse and heterogeneous with differing distribution and product differentiation strategies being implemented and pursued. In particular, businesses employing primarily a personified distribution strategy (e.g. direct sales via farmers markets) differ quite substantially from businesses employing mainly a standardized distribution strategy (e.g. via retail) in their economic characteristics. Moreover, differences in the perception of potential benefits of local food as well as in the underlying drivers to become part of local FVCs were detected across businesses with different distribution strategies.Research limitations/implicationsAlthough the employed data sample is considered adequate for analyzing heterogeneity in firms' business strategies, the sample is not representative for Denmark and cannot straight-forwardly be extrapolated to the population level.Originality/valueOne of the first quantitative study on producers' and processors' perceptions of local food and its interaction with organic farming. So far, there is a large literature on consumers' perceptions but empirical evidence for other stakeholders is scarce. Hence, the present study provides a complementary perspective on the topic of local food.
Who does the media love? A qualitative content analysis of the narratives of founders and nonfounders in IPO firms
Authors: Tupper Christina H. 
Published: May 2021

PurposeResearchers have investigated the distinctions between founder and nonfounder chief executive officers (CEOs) for different performance variables. Researchers have also investigated the use of media as supplemental information that investors review to make decisions about initial public offering (IPO) firms. Research that investigates founders and nonfounder CEOs of IPO firms in the media is limited but growing. This paper aims to explore how founder and nonfounder CEOs' narratives are portrayed differently in business media following an IPO.Design/methodology/approachUsing insights from the narrative paradigm, 1,057 news paragraphs about CEOs from 19 matched pairs (38 firms) were content analyzed using a contrasting coding strategy.FindingsFounders and nonfounders' narratives differ in three ways. Specifically, founder CEOs are more likely to (1) have their personal background detailed in the media, (2) translate technical business information to easy-to-understand general language and (3) be quoted talking about positive information than nonfounder CEOs.Research limitations/implicationsThe results of this study show the media's role in creating narratives about management and how the experiences of founders and nonfounders are represented differently in the media. The study is limited by only investigating media articles about CEOs and not investigating the entire organizational narrative.Originality/valueThis study adds to the growing literature that investigates the role the media plays in portraying management in the media at time of IPO.