bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of tyrosine kinase inhibitors for paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia: a systematic review and meta-analysis
Authors: Chen Min , Zhu Yiping , Lin Yunzhu , Tengwang Tianzi , Zhang Lingli 
Published: January 2021

ObjectivesTo investigate the effectiveness and safety of tyrosine kinase inhibitors (TKIs) in the management of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ALL).DesignA systematic review and meta-analysis.Data sourcesElectronic searches were conducted on CENTRAL, MEDLINE, EMBASE, SIOP, ASPHO, ASCO, ASH and four Chinese databases from inception to 8 March 2020. Language of publications was restricted in English and Chinese.Eligibility criteriaProspective and retrospective comparative studies were included.Data extraction and synthesisTwo authors independently assessed and extracted data. Quality of studies was assessed by the Cochrane Collaboration’s tool and Newcastle-Ottawa Scale. Subgroup analysis was performed by comparing different types of TKIs. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.ResultsTwo randomised controlled trials (RCTs) and four cohort studies enrolling 536 patients were included. For RCTs, the pooled HR was 0.68 (95% CI 0.26 to 1.78) in overall survival (OS), 0.63 (95% CI 0.28 to 1.42) in event-free survival (EFS), respectively, comparing TKI arm with non-TKI arm for treatment of paediatric Ph+ALL. There was significant difference in OS and EFS between imatinib arm and dasatinib arm (HR 2.26, 95% CI 1.02 to 5.01; HR 2.36; 95% CI 1.27 to 4.39, respectively). For cohort studies, the pooled HR was 0.25 (95% CI 0.14 to 0.47) in OS, 0.25 (95% CI 0.12 to 0.56) in EFS, respectively, comparing TKI arm with non-TKI arm. There was no significance difference in adverse drug reaction between TKI group and without TKI group (risk ratio (RR) 0.82, 95% CI 0.63 to 1.08 in RCT; RR 1.01, 95% CI 0.64 to 1.59 in cohort studies; respectively), and imatinib versus dasatinib (RR 0.97, 95% CI 0.77 to 1.23). The quality of evidence was rated as low for OS, EFS and adverse drug reaction (ADR).ConclusionsThe combination of TKIs with chemotherapy is likely to improve the OS and EFS rates in paediatric Ph+ALL, and dasatinib is superior than imatinib. Large sample size and prospective controlled studies are warranted.PROSPERO registration numberCRD42018104107.
Fingertip pulse oximetry prevented premature declaration of death
Authors: Kiedrowski Miroslaw , Kapala Przemyslaw , Deptala Andrzej 
Published: January 2021

ObjectiveWe describe a case of persisting readings from a fingertip pulse oximeter (FPO) in an elderly cachectic woman with pancreatic cancer, who fulfilled all classical criteria of death.MethodsIt is an instructive example of a home hospice patient who died during the physician’s intervention. Although all classical signs of death had been confirmed several times, a portable FPO continued to indicate satisfactory saturation and pulse readings for the following 30 min.ResultsOur case report confirms that the classical criteria of death might sometimes be faulty. The application of a portable FPO prevented a premature declaration of death.ConclusionIn exceptional cases, even the most careful physical examination may erroneously indicate that a person is dead. A residual cardiac output and gas exchange may be preserved and revealed by FPO readings. In doubtful situations, FPO can provide additional information and prevent a premature declaration of death.
Slavery de jure and de facto: The United Nations’ Definition of Slavery and Its Incomplete Dutch Translation in Belgium, The Netherlands, and Suriname
Authors: Paschke Boris 
Published: January 2021

Abstract
The international legal definition of slavery (Art. 1 Slavery Convention [1926]; Art. 7 Supplementary Convention [1956]) distinguishes between slavery de jure and slavery de facto. The definition puts the emphasis on slavery de facto. However, by letting some words untranslated, the respective Dutch translation prevalent in Belgium, The Netherlands, and Suriname (unintentionally) focuses on slavery de jure. Nowadays, slavery is illegal (Art. 4 udhr; Art. 4 echr) and, thus, only exists de facto. A corrected and completed Dutch translation will increase the awareness of the various forms of slavery de facto. In so doing, it can make an important contribution to the fight against slavery.
A Genealogy of Lust
Authors: Olivero Vladimir 
Published: January 2021

Abstract
In this study I argue that the translator of Prov 24:50–51 LXX (30:15–16 MT) adapts the Hebrew text to his Hellenistic audience by alluding to Hesiod’s Theogony. The core message of these verses—the ineluctability of cosmic greed—remains the same, yet the images employed in the Septuagint are engrained in and originally belong to the Hellenic mythological understanding of how the universe came into being. The use of classical literature to convey the message contained in the texts of the Hebrew Bible speaks to the hybrid character of the Jewish community of the Egyptian diaspora. When the translator quotes or alludes to Greek literature, he is not borrowing foreign material, but rather drawing wisdom from his very own well. In Alexandria, the waters that flowed from the rock at Horeb and from the Hippocrene spring have merged their course.
Interdecadal Change in the Relationship between the Winter North Pacific Storm Track and the East Asian Winter Monsoon
Authors: Yang Minghao , Li Chongyin , Li Xin , Tan Yanke , Chen Xiong , Zhang Chao 
Published: January 2021

AbstractBased on the daily NCEP reanalysis, the present study investigates the interdecadal change in the relationship between the winter North Pacific storm track (WNPST) and the East Asian winter monsoon (EAWM), and evaluates the WNPST–EAWM relationship in 17 CMIP6 models. The results show that the out-of-phase WNPST–EAWM relationship underwent an interdecadal change in the mid-1980s. The WNPST–EAWM relationship became less significant during period 2 (P2; 1990–2015). The atmospheric circulation anomaly related to the EAWM during period 1 (P1; 1955–80) is more robust than that during P2. The interdecadal weakening WNPST–EAWM relationship may be attributed to the interdecadal damping WNPST–EAWM interaction. The EAWM-related anomalous baroclinic energy conversion and moisture effects, including meridional and vertical eddy moisture fluxes, contribute to the significant attenuation of the WNPST during P1. The transient eddy-induced dynamic forcing and thermal forcing anomalies, as well as the barotropic process represented by the local Eliassen–Palm flux divergence associated with WNPST, can also significantly manipulate the upper-tropospheric jet during P1. However, the atmospheric circulation and interaction between the WNPST and EAWM during P2 are not as significant as those during P1. The effect of ENSO on the WNPST is significantly different before and after the mid-1980s. After the mid-1980s, the WNPST shows the characteristic of moving equatorward during El Niño events. It seems that ENSO takes over the WNPST from the EAWM after the mid-1980s. In addition, except for BCC-ESM1, CanESM5, and SAM0-UNICON, most of the CMIP6 models cannot reproduce the significant out-of-phase WNPST–EAWM relationship.
Clouds and Vegetation Modulate Shallow Groundwater Table Depth
Authors: Shrestha Prabhakar 
Published: January 2021

AbstractA 10-yr simulation of shallow groundwater table (GWT) depth over a temperate region in northwestern Europe, using a physics-based integrated hydrological model at kilometer scale, exhibits a strong seasonal cycle. This is also well captured in terms of near-surface soil moisture anomalies, terrestrial water storage anomalies, and shallow GWT depth anomalies from observations over the region. The modeled monthly anomaly of GWT depth exhibits a statistically significant (p < 0.05) moderate positive/negative correlation with non-rain- and rain-affected monthly anomalies of incoming solar radiation. The vegetation cover also produces a strong local control on the variability of shallow GWT depth. Thus, much of the variability in the simulated seasonal cycle of shallow GWT depth could be linked to the distribution of clouds and vegetation. The spatiotemporal distribution of clouds, partly influenced by the Rhine Massif, modulates the seasonal variability of incoming solar radiation and precipitation over the region. Particularly, the southwestern and northern part of the Rhine Massif divided by the Rhine Valley exhibits a dipole behavior with relatively high (low) shallow GWT depth fluctuations, associated with positive (negative) anomaly of incoming solar radiation and negative (positive) anomaly of precipitation.
An in-depth evaluation of personal barriers to technology adoption in irrigated agriculture in South Africa
Authors: de Witt Marlene , de Clercq Willem Petrus , Velazquez Francisco José Blanco , Altobelli Filiberto , Marta Anna Dalla 
Published: January 2021

Increasing pressure on water resources is driving the development of technology to improve water-use efficiency in irrigation. Uptake of these technological advances are essential to ensure long-term water security in catchments, particularly in water-scarce regions and where agricultural activities and urban centres compete for the same resources. Research suggests that uptake of technology lags far behind the development of new products. The study presented in this paper interviewed 29 commercial farmers from the water-scarce Central Breede River Valley in South Africa to investigate their reasons behind the use or non-use of irrigation technology for scheduling, and in particular the uptake of a free, government-funded remote-sensing service called FruitLook. Evaluating the uptake of a free service eliminates monetary cost as one key barrier to uptake. In-depth interviews revealed a high uptake of technology (83%), but use of only one type – soil water measurement. Among the farmers that use water-use efficiency technology, 78% use the same probe service provider. Perceived accuracy and ease of use, as well as personalised after-sales service are the key reasons for this probe’s popularity. While 86% of the farmers have heard about FruitLook, only one farmer uses it for irrigation purposes. The non-use of the free service can mainly be attributed to the time cost associated with the product’s initial set-up, use, and interpretation of information. The study revealed that the integration of information from various products is essential for farmers – too much information in different formats is too time-costly. Developers of new technology should focus on these latter two findings to improve the likelihood of new product uptake.
Myositis in systemic lupus erythematosus
Authors: Cotton Thaisa , Niaki Omid Zahedi , Zheng Boyang , Pineau Christian A , Fritzler Marvin , Vinet Evelyne , Clarke Ann E , Bernatsky Sasha 
Published: January 2021

Objectives Myositis is an infrequent feature of SLE and may often be overlooked. We aimed to estimate the incidence of myositis in SLE, and to determine demographic and clinical factors associated with it. Methods Within our lupus cohort, we identified potential myositis cases using the SLICC Damage Index for muscle atrophy or weakness, the SLEDAI-2K item for myositis, and annually measured serum creatinine kinase. Cases were confirmed through chart review. We performed descriptive analyses of prevalent myositis cases as of January 2000. From that point onward, we studies patients without myositis to determine risk of incident myositis, using cohort analyses adjusted for demographic variables (age, sex, race/ethnicity). Results As of January 2000, there were 5 prevalent myositis cases in our SLE cohort. Among 560 SLE patients with a study visit from January 2000 onward, with no history of myositis at baseline, 5 new cases (4 females, 1 male) were identified over an average follow-up of 8.5 years (incidence 1.05 cases per 1000 person-years). There was a higher proportion of Caucasians in the non-myositis group versus myositis group, with a trend for fewer females in the myositis cases. Arthritis, Raynaud’s phenomenon, and anti-Smith antibodies were common pre-existing features, occurring in all incident myositis cases. In Cox regression analyses adjusting for age, race/ethnicity and sex, non-Caucasian patients had a markedly increased risk of developing myositis. Conclusion We found a low incidence of myositis in our SLE cohort. A cluster of variables, particularly non-Caucasian race/ethnicity, arthritis, Raynaud’s phenomenon, and anti-Smith antibodies were associated with risk of developing myositis in SLE. These variables may aid clinicians in identifying SLE patients at highest risk for this important complication.
The utility of teledermatology in the evaluation of skin lesions
Authors: Clarke Emily L , Reichenberg Jason S , Ahmed Ammar M , Keeling Brett , Custer James , Rathouz Paul J , Jambusaria-Pahlajani Anokhi 
Published: January 2021

Introduction Past studies have shown mixed results about the accuracy of store-and-forward (SAF) teledermatology in the evaluation of skin lesions. The objective of this study is to determine the accuracy of SAF teledermatology in the diagnosis of skin lesions and biopsy decision compared to in-person clinical evaluation. Methods Histories and photographs of skin lesions gathered at clinic visits were sent as SAF consults to teledermatologists, whose diagnoses and biopsy decisions were recorded and compared statistically to the clinic data. Results and Discussion: We enrolled 206 patients with 308 lesions in the study. The study population was composed of 50% males ( n = 104), and most patients were white ( n = 179, 87%) and not Hispanic/Latino ( n = 167, 81%). There was good concordance for biopsy decision between the clinic dermatologist (CD) and teledermatologist (TD) (Cohen’s kappa (κ) = 0.51), which did not significantly differ when melanocytic lesions were excluded (κ = 0.54). The sensitivity and specificity of teledermatology based on biopsy decision was 0.71 and 0.85, respectively. Overall concordance in first diagnosis between the CD and TD was good (κ = 0.60). While there was no difference between CD and TD in proportion of correct diagnoses compared to histopathology, two skin cancers presentations were missed by TD. Study limitations included sample size, enrolment bias and differing amounts of teledermatologist case experience. Teledermatology has good concordance in diagnosis and biopsy decision when compared to clinic dermatology. Teledermatology may be utilized in the evaluation of skin lesions to expand access to dermatologic care.
Lumbar Disc Herniation and Preoperative Modic Changes: A Prospective Analysis of the Clinical Outcomes After Microdiscectomy
Authors: Kumarasamy Dinesh , Rajasekaran Shanmuganathan , Anand K. S Sri Vijay , Soundararajan Dilip Chand Raja , Shetty T Ajoy Prasad , Kanna P Rishi Mugesh , Pushpa B.T 
Published: January 2021

Study design: Prospective comparative cohort study. Objectives: The study aims to elucidate the relationship between Modic endplate changes and clinical outcomes after a lumbar microdiscectomy. Methods: Consecutive patients undergoing microdiscectomy for lumbar disc herniation (LDH) were prospectively studied. Pre-operative clinical and radiological parameters were recorded. The pain was assessed by Numeric pain rating scale (NPRS), and functional assessment by Oswestry Disability Index (ODI). Minimal clinically important difference (MCID) in outcome was calculated for both the groups. Complications related to surgery were studied. Follow-up was done at 6 weeks, 3 months, 6 months and 1 year. Mac Nab criteria were used to assess patient satisfaction at 1 year. Results: Out of 309 patients, 86 had Modic changes, and 223 had no Modic changes. Both groups had similar back pain (p-value: 0.07) and functional scores (p-value: 0.85) pre-operatively. Postoperatively patients with Modic changes had poorer back pain and ODI scores in the third month, sixth month and 1 year (p-value: 0.001). However, MCID between the groups were not significant (p-value: 0.18 for back pain and 0.58 for ODI scores). Mac Nab criteria at 1 year were worse in Modic patients (p-value: 0.001). No difference was noted among Modic types in the pre-operative and postoperative pain and functional outcomes. Four patients in Modic group (4.7%) and one patient in the non-Modic group (0.5%) developed postoperative discitis (p-value: 0.009). Conclusions: Preoperative Modic changes in lumbar disc herniation is associated with less favorable back pain, functional scores and patient satisfaction in patients undergoing microdiscectomy.
Auxin is involved in arbuscular mycorrhizal fungi-promoted tomato growth and NADP-malic enzymes expression in continuous cropping substrates
Authors: Wang Yu , Zhang Wenze , Liu Weikang , Ahammed Golam Jalal , Wen Wenxu , Guo Shirong , Shu Sheng , Sun Jin 
Published: January 2021

Abstract
Background
Despite significant limitations of growth medium reuse, a large amount of organic substrate is reused in soilless cultivation of horticultural crops in China. Arbuscular mycorrhizal fungi (AMF) can promote nutrient absorption and improve plant tolerance to biotic and abiotic stresses. However, the mechanisms governing the effects of AMF on crop growth in organic continuous cropping substrates have not been elucidated.

Results
In this study, we showed that the inoculation of AMF in continuous cropping substrates promoted growth and root development, and increased the root and NADP-malic enzyme (NADP-ME) activity of tomato seedlings. Root transcriptome analysis demonstrated that the plant hormone signal transduction pathway was highly enriched, and 109 genes that positively correlated with the AMF-inoculated plant phenotype were obtained by gene set enrichment analysis (GSEA), which identified 9 genes related to indole acetic acid (IAA). Importantly, the levels of endogenous IAA in tomato seedlings significantly increased after AMF inoculation. Furthermore, the application of AMF significantly increased the expression levels of NADP-ME1 and NADP-ME2, as well as the activity of NADP-ME, and enhanced the root activity of tomato seedlings in comparison to that observed without inoculation of AMF. However, these effects were blocked in plants treated with 2,3,5-triiodobenzoic acid (TIBA), a polar transport inhibitor of IAA.

Conclusions
These results suggest that IAA mediates the AMF-promoted tomato growth and expression of NADP-MEs in continuous cropping substrates. The study provides convincing evidence for the reuse of continuous cropping substrates by adding AMF as an amendment.
A unique case of diagnosis of a heterotopic pregnancy at 26 weeks – case report and literature review
Authors: Kajdy Anna , Muzyka-Placzyńska Katarzyna , Filipecka-Tyczka Dagmara , Modzelewski Jan , Stańczyk Marek , Rabijewski Michał 
Published: January 2021

Abstract
Background
Heterotopic pregnancy (HP) is a rare condition when at least two pregnancies are present simultaneously at different implantation sites and only one located in the uterine cavity. The majority of cases are diagnosed in the first trimester.

Case presentation
We present a unique case of HP diagnosed at 26 weeks of spontaneous pregnancy in a patient without any relevant risk factors. We performed an extensive review of HP cases from MEDLINE (PUBMED) published in English between 2005-2019 to prove this case's uniqueness.
A 24-year-old woman presented because of threatened preterm birth. Despite treatment, pain aggravated, without progression of labor. An emergency ultrasound exam revealed free fluid in the abdominal cavity. Suspicion of active bleeding prompted the medical team to perform an exploratory laparotomy. The surgery team found a ruptured heterotopic pregnancy. This was an unexpected cause of nontraumatic hemoperitoneum at such advanced gestational age. The postoperative period was uneventful, and the intrauterine pregnancy continued to term.
The final review included 86 out of 124 records. A total number of 509 cases were identified, but not all of them had complete data. The maximum reported gestational age at the time of diagnosis was 16 weeks of pregnancy, while our case became symptomatic and was diagnosed at 26 weeks of pregnancy.

Conclusions
Regardless of pregnancy age, HP can be a cause of hemoperitoneum, and it should be included in the differential diagnosis of acute abdomen in the second trimester.
Breastfeeding, prenatal depression and children’s IQ and behaviour: a test of a moderation model
Authors: Amiel Castro Rita , Glover Vivette , Ehlert Ulrike , O’Connor Thomas G. 
Published: January 2021

Abstract
Background
We aimed to determine the associations between breastfeeding and children’s neurodevelopment indexed by intelligence quotient (IQ) and emotional and behavioural problems through mid-childhood adjusting for prenatal and postnatal depression and multiple confounders; and to test the novel hypothesis that breastfeeding may moderate the effects of prenatal depression and anxiety on children’s neurodevelopment.

Methods
The study is based on women and their children from the longitudinal Avon Longitudinal Study of Parents and Children (n=11,096). Children’s IQ was derived from standardized in-person testing; behaviour problems were assessed according to parent-report; information on breastfeeding, prenatal depression and anxiety and multiple confounders were derived from self-report questionnaires. We conducted hierarchical multiple regression adjusting for several covariates.

Results
43% women were exclusively breastfeeding at 1 month and an additional 16.8% were engaged in mixed or partial breastfeeding. Both exclusive breastfeeding (B = 2.19; SD = 0.36, p =.00) and mixed feeding (B = 1.59; SD= 0.52; p=.00) were positively associated with IQ at 8 years of age, after adjusting for covariates. Exclusive breastfeeding was negatively associated with hyperactivity/attention deficit at 4 years (B = −.30, SD = .05; p < .01); mixed feeding was related to hyperactivity/attention deficit at age 9 (B = .20; SD = .08; p = .03) after adjustments. There was no association between breastfeeding and emotional or conduct problems. Breastfeeding did not moderate the association between prenatal depression and anxiety and children’s neurodevelopment.

Conclusions
The selective association between breastfeeding and neurodevelopmental measures suggests a nutritional rather than broader beneficial psychological effect on child neurodevelopment. Breastfeeding did not moderate the associations between prenatal depression and anxiety and child neurodevelopment, suggesting separate mechanisms of action.