bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective effects of calorie restriction on insulin resistance and islets function in STZ-induced type 2 diabetes rats
Authors: Zhang Li , Huang Ying-juan , Sun Jia-pan , Zhang Ting-ying , Liu Tao-li , Ke Bin , Shi Xian-fang , Li Hui , Zhang Geng-peng , Ye Zhi-yu , Hu Jian-guo , Qin Jian 
Published: February 2021

Abstract
Background Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.Methods Sixty male Sprague-Dawley rats were used in this study. The diabetes model was induced by 8 weeks of high-fat diet (HFD) followed by a single dose of streptozotocin injection (30 mg/kg). Subsequently, the diabetic rats were fed HFD at 28 g/day (diabetic control) or 20 g/day (30% CR regimen) for 20 weeks. Meanwhile, normal rats fed a free standard chow diet served as the vehicle control. Body mass, plasma glucose levels, and lipid profiles were monitored. After diabetes-related functional tests were performed, the rats were sacrificed at 10 and 20 weeks, and glucose uptake in fresh muscle was determined. In addition, western blotting and immunofluorescence were used to detect alterations in AKT/AS160/GLUT4 signaling. Results We found that 30% CR significantly attenuated hyperglycemia and dyslipidemia, leading to alleviation of glucolipotoxicity and thus protection of islet function. Insulin resistance was also markedly ameliorated, as indicated by notably improved insulin tolerance and homeostatic model assessment for insulin resistance (HOMA-IR). However, the improvement in glucose uptake in skeletal muscle was not significant. The upregulation of AKT/AS160/GLUT4 signaling in muscle induced by 30% CR also attenuated gradually over time. Interestingly, the consecutive decrease in AKT/AS160/GLUT4 signaling in white adipose tissue was significantly reversed by 30% CR. Conclusion CR (30%) could protect islet function from hyperglycemia and dyslipidemia, and improve insulin resistance. The mechanism by which these effects occurred is likely related to the upregulation of AKT/AS160/GLUT4 signaling.
Analysis on transformer vibration signal recognition based on convolutional neural network
Authors: Cai Yonghua , Hou Aixia 
Published: February 2021

In order to study the relationship between the transformer vibration and the operation state, the wavelet analysis method and the convolutional neural network method were used to analyze the transformer vibration signal. This paper proposes a transformer based on convolution neural network-based surface vibration signal feature extraction method. The result show that the convolution of neural network in different station transformer surface vibration signal classification has a lot of advantage, as the integration of feature extraction and classification recognition process together can effectively classify vibration signal recognition processing. This method is feasible for classification and identification by providing an accuracy value of 92.74 %. The future perspective of this research will focus on a generalized network model and parameters through experimentation for further investigation of accuracy and efficiency of this method.
Water policy and regional economic development: evidence from Henan province, China
Authors: Bai Hefei , Tang Ke , Zhao Ximeng , Yu Zhijian 
Published: February 2021

Abstract
With the rapid advance of industrialization and urbanization and the intensified impact of global climate change, the contradiction between the global water shortage and economic growth has become prominent. This paper, taking Henan province as an example, analyzed the influence of water resource policy on regional economic growth through a calculable general equilibrium model and further discussed the relevant policy recommendations. The results showed that the improvement of water supply, water efficiency and water technology could promote the growth of the regional economy and result in a positive effect on regional GDP, employment and resident income. However, the rise of water price has a negative impact on regional economic development, mainly reflected in regional GDP, employment and household income. The improvement of water price, water efficiency and water conservancy technology would lead to a decrease in regional water consumption, while only the increase of the water supply would lead to an increase in water consumption. Accordingly, the paper puts forward policy suggestions, such as accelerating the improvement of water conservancy facilities, establishing a reasonable water price mechanism and actively exploring experience in water conservation and emission reduction.
Estimating the groundwater storage for future irrigation schemes
Authors: Abdul-Ganiyu Shaibu , Prosper Kpiebaya 
Published: February 2021

AbstractPresented in this paper is a feasibility study of groundwater for agricultural use (irrigation) in Northern Ghana. The study was conducted using geo-electrical data, boreholes drill logs, results of water quality, and results of the pumping test. The geo-electrical results were to unearth the lithology of the study area; it was found to be underlain with varying geology of both Precambrian and Paleozoic sedimentary formation. These formations consist of phyllite, schist, granite, meta-sediments, and meta-volcanics making up the Precambrian and sandstone, shale, siltstone, mudstones, granitiods also, of the Paleozoic sedimentary. Areas of low resistivity were targeted for drilling per the geophysical results of the profile, values between 24 and 100 ohm.m were zones of probable groundwater occurrence in the study. The groundwater storage capacity and the extractable storage capacity were estimated to be approximately 710,000 km3 and 290,000 km3. The pumping test results acquired from 81 boreholes from the study were used to analyze the sustainability. However, groundwater depth was studied using the Static water level (SWL), areas of SWL around 22 m and 25 m are likely to have a shallow depth whereas areas of 17 m would have deeper groundwater depth.
Development and numerical modelling of a novel UV/H2O2 rotating flow reactor for water treatment
Authors: Luo Minghan , Xu Wenjie , Jeong Taeseop 
Published: February 2021

Abstract
The ultraviolet photochemical degradation process is widely applied in wastewater treatment due to its low cost, high efficiency and sustainability. In this study, a novel rotating flow reactor was developed for UV-initiated photochemical reactions. The reactor was run in a continuous flow mode, and the tangential installation of the inlet and outlet on the annular reactor improved reaction rates. Numerical modelling, which combined solute transport, radiation transfer and photochemical kinetic degradation processes, was conducted to evaluate improvement compared to current reactor designs. Methylene Blue (MB) decomposition efficiency from the modelling results and the experimental data agreed well with each other. The model results showed that a rotational motion of fluid was well developed inside the designed reactor for a wide range of inflow rates; the generation of ·OH radicals significantly depended on UV irradiation dose, and thus the degradation ratio of MB showed a strong correlation with the UV irradiation distribution. In addition, the comprehensive numerical modelling showed promising potential for the simulation of UV/H2O2 processes in rotating flow reactors.
STRATEGI PEMBENTUKAN KARAKTER SPIRITUALITAS KEAGAMAAN DAN CINTA TANAH AIR (Perspektif Filsafat Pendidikan Islam)
Authors: Maragustam Maragustam 
Published: February 2021

The globalization current is very influential towards the formation of one's character whether to be character or to be a character tuna. The issue is how to make someone character and avoid the character's tuna. For that, then what will be answered in this study is how the strategy of the character formation of religious spirituality and love of Homeland? What are the values that need to be attributed? The scientific approach used was the philosophy of Islamic education with an eclectic incorporative. The study is entirely a kind of qualitative research-a library with a variety of litertur related to the character. Data collection with documentation. Its analytical techniques (1) Content analysis, (2) Miles and Huberman (data collection, data reduction, data desplay, and data verification), and (3) data triangulation. Research results; First, the strategy of establishing religious spirituality characters and the love of Homeland is habituation, moral knowing, moral feeling, immorality, and repentance with the throne, Takhalli, Tahalli, and Tajalli. Secondly, the primary value implanted is religious spiritual. From this core value will give birth to the value of love of homeland, integrity (honesty-trust), responsibility, respect, humility, tolerance, social care, love of science, hard work, patience, self-reliant, and silaturrahim.
Left ventricular geometric sportsmen power sports heavyweight with arterial hypertension
Authors: Miroshnikov Alexander B. , Smolensky Andrey V. 
Published: February 2021

Aim.To conduct a comparative analysis of the geometry of the left ventricle (LV) at sportsmen heavyweight power sports with hypertension.
Material and methods.We examined 238 representatives of power sports (weightlifting, powerlifting, bodybuilding) with an average body weight of 102.76.4 kg and arterial blood pressure at rest: systolic blood pressure 157.45,6, diastolic blood pressure 91.25.3. Along with the examination, all examined athletes underwent: bioimpedansometry, standard resting electrocardiogram, two-fold measurement of blood pressure, transthoracic echocardiography.
Results.A survey of 238 weightlifting athletes of heavy weight categories with arterial hypertension showed an increased fat component in powerlifters (SAT 31.83.3%; BMI 34.41.3 kg/m2; Fat Mass Index 10.91,1 kg/m2; Fat-to-Muscle Ratio 0.50.1) and a sufficiently large muscle component: bodybuilding Fat Free Mass Index (FFMI) 26.92.1 kg/m2; powerlifting FFMI 23.51.6 kg/m2and weightlifting FFMI 23.71.8 kg/m2. The examination also showed a violation of the geometry of the LV. For athlete powerlifters, the following LV parameters were noted: LVMM 270.228.7 g; LVMI 123.77.9 g/m2; RWTLV 0.460.03 sm. For representatives of weightlifting; LVMM 267.832.3 g; LVMI 121.48.6 g/m2; RWTLV 0.450.02 sm. For bodybuilder athletes: LVMM 271.418.9 g; LVMI 120.16.3 g/m2; RWTLV 0.300.01 sm.
Conclusion.Thus, the patterns obtained in relation to the geometry of the heart of athletes of power sports, heavy weight categories with arterial hypertension, can serve as a scientific basis for the formation of some aspects of the preventive program of physical rehabilitation with a priority focus on risk groups in such men.
Comparison of the results in Normal Flow High Gradient and Low Flow Low Gradient patients after correction of pronounced aortic stenosis with Ozaki procedure in the long-term observation
Authors: Bazylev Vladlen V. , Tungusov Dmitrii S. , Babukov Ruslan M. , Bartosh Fedor L. , Mikulyаk Artur I. , Gorshkova Alena V. 
Published: February 2021

Relevance.It has been proven that patients with Low Flow Low Gradient (LFLG) after aortic valve replacement with biological or mechanical prostheses have a higher mortality rate and the number of adverse events compared with patients with Normal Flow High Gradient (NFHG). However, there are currently no comparative studies of patients with NFHG and LFLG after the Ozaki procedure. The better hemodynamic properties of autopericardial cusps compared with biological prostheses can more favorably influence the results in patients with LFLG in the short and long-term follow-up periods.
Aim.1. Compare the hospit and long-term results of patients of the LFLG group with the results of patients of the NFHG group after the Ozaki procedure. 2. Identify predictors of hospital and long-term mortality in patients with LFLG.
Materials and methods.All patients have been divided into two groups. Group 1: 137 patients with NFHG and signs of classic aortic stenosis: AVA1 cm2, Gmean40, SV index 35 ml/m2and normal left ventricle (LV) ejection fraction. Group 2. 71 patients with LFLG and underestimation of the average gradient indices (Gmean40) despite a decrease in the aortic valve aperture AVA1 cm2amid a decrease in the index of stroke volume 35 ml/m2and LV systolic function.
Results.Hospital mortality after surgical correction of AV stenosis was significantly higher in patients of group 2: 3 (4.2%) patients and 1 (0.7%) patients, respectively (p=0.002). Survival at the maximum follow-up period for patients with LFLG was significantly lower than in the group of patients with NFHG 88.6 (95% confidence interval CI 4449.6) and 97.8 (95% CI 48.951), respectively (p=0.009). According to the results of the Cox regression analysis, the independent predictors of mortality in the long-term follow-up of patients with LFLG are the SV odds ratio 0.8 (95% CI 0.91.1);p=0.008 and the global longitudinal LV deformation (GLS) odds ratio 0.56 (95% CI 0.471.1);p=0.01.
Conclusions.1. After the Ozaki procedure, patients with the LFLG group have higher risks of adverse events, both at the hospital stage and in the long-term follow-up, compared to patients with NFHG. 2. The duration of ischemia and LV mass are predictors of hospital mortality in the LFLG group of patients. 3. Predictors of long-term mortality in patients with LFLG are LV stroke volume index and global longitudinal LV deformation.
Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
Authors: Zakirova Aliara N. , Abdiukova Elvina R. , Viktorov Vitalii V. , Zakirova Nelli E. , Nizamova Dinara F. 
Published: February 2021

Aim.To evaluate the effect ofb-blockers (BB) on myocardial remodeling and endothelial adhesive function in patients with chronic heart failure (CHF) and atrial fibrillation (AF) of ischemic origin.
Material and methods.The study included 77 patients with functional class IIIII CHF and AF who had previously suffered a large-focalQ-myocardial infarction. Patients were randomized into 2 groups, comparable in clinical and instrumental characteristics and homogeneous in basic therapy of CHF and AF. Group 1 included 40 patients who took carvedilol for 24 weeks as part of the basic therapy of CHF and AF, and group 2 included 37 patients who received metoprolol tartrate. We used clinical and instrumental (echocardiography, 6-minute walking test, clinical assessment scale) and enzyme immunoassay (analysis of the level of soluble molecules of intercellular adhesion sVCAM-1 and sE-selectin) research methods.
Results.The use of carvedilol a non-cardioselective BB that performsa1,b1andb2-adrenoblockade, andb1-selective, short- acting BB metoprolol tartrate as part of basic therapy improved the clinical condition and physical performance of patients with CHF and AF. It was found that carvedilol more significantly than metoprolol affects the state of intracardiac hemodynamics, slows down the processes of remodeling of the left atrium and left ventricle, increases the contractile function of the myocardium. Carvedilol as part of basic therapy reduces endothelial adhesion and inhibits the overexpression of intercellular adhesion molecules sVCAM-1 and sE-selectin, and when using metoprolol tartrate, there is only a tendency to decrease these indicators.
Conclusion.Carvedilol as part of the basic therapy of CHF and AF has significant endothelial-protective and clinical-hemodynamic effects, positively affects the adhesive function of the endothelium and the processes of left atrium and left ventricle remodeling.
El camino es árduo y está sembrado de peligros: los warao del Delta del Orinoco
Authors: González Muñoz Jenny 
Published: February 2021

La cosmovisión indígena se constituye en parte de la tradición oral del pueblo, teniendo una continua vigencia por medio de la transmisión de generación en generación, que si bien debe ser observada desde la perspectiva de la diferenciación entre las versiones existentes y por existir, es parte esencial en la memoria social del pueblo, bien sea en el soporte oral como en el lugar de la memoria escrita a la manera occidental. El presente ensayo se enfoca en el análisis del mito de origen conocido como “La aparición de los warao”, “Buen Brazo” o “Jarayaquera”, de la etnia warao (Delta del Orinoco, Venezuela) en dos versiones, y la perspectiva indígena de realidades y eternidades que se desprenden de dicha etnohistoria en el ámbito contemporáneo.
Bibliometric Analysis of Trends in Theory-related Policy Publications
Authors: Zahra Abitassha Az , Nurmandi Achmad , Tenario Christine B. , Rahayu Riska , Benectitos Samantha Herector , Mina Faye Lorraine P. , Haictin Ken M. 
Published: February 2021

This study's bibliometric analysis evaluates the scope and trends of theory-related policy publications in various international journals. The method used the Scopus search engine on random journals in identifying policy-related publications. The study also used a data visualization software called VOSviewer to analyze the results, underlying network linkages, and information production trends in policy analysis. The findings shows that only a few proportions of policy-related researches apply theories in their study. Field-specialized journals were having practitioners publish less research as compared to interdisciplinary science and technology journals. This article calls for greater engagements among scholars, and for policy researchers to more explicitly consider how their work might contribute to the understanding of the policy challenges. The findings also shows that it is important to recognize the approach and theory behind policy development to determine the incremental nature of aspects involved in policy development. It is extremely valuable to be clear that if one deals only with conceptual level of policy research without testing those ideas against independent empirical information, then scientific theory development is not possible. Thus, failure to consistently and clearly make theory connection towards policy research is a lost opportunity for scholars to influence policy thinking and public argument. Doi: 10.28991/esj-2021-01261 Full Text: PDF
DIAGNOSIS OF DIABETIC RETINOPATHY THROUGH SCREENING OF RETINAL IMAGES
Authors: Purushottama  , C Kishore 
Published: February 2021

Diabetic Retinopathy (DR) is progressive dysfunction of the retinal blood vessels caused by chronic hyperglycemia which can be a complication of diabetes type 1 or diabetes type 2. Initially, DR is asymptomatic, if not treated though it can cause low vision and blindness. Diabetic retinopathy is responsible for 1.8 million of the 37 million cases of blindness throughout the world. So the early detection of Diabetic retinopathy through proper screening is essential.
The paper presents a Diabetic Retinopathy Screening System which can be used as a primary diagnosis tool by ophthalmologists in the screening process to detect symptoms of Diabetic Retinopathy. The system uses the anatomical structures such as blood vessels, exudates and microaneurysms in retinal images. The retinal images are segmented and classified as normal or DR affected images by extracting features from segmented images and the Gray Level Co-occurrence Matrix (GLCM). The classifier used is Support Vector Machine (SVM) which gives a better accuracy.
The system is implemented and tested in MATLAB and LabView for the standard database and need to be optimized for real time screening of images. LabView creates distributable .EXE files and .DLL files which can be downloaded into the FPGA/DSP processor. Hardware implementation on LabView FPGA presents a small learning curve which drastically reduces development time and eliminates the need for custom hardware design.
IDENTIFIKASI SIFAT FISIS KANDIDAT WAFER DARI LIMBAH TAHU SEBAGAI ALTERNATIF PAKAN TERNAK
Authors: Rahayu Susi , Nurhidayati Nurhidayati , Kurniawidi Dian Wijaya , Alaa Siti 
Published: February 2021

Inovasi pembuatan pakan ternak dalam sediaan wafer perlu dilakukan untuk menjadi alternatif pakan saat musim kemarau. Limbah tahu merupakan salah satu bahan dasar yang dimanfaatkan sebagai bahan pembuatan wafer. Tujuan penelitian ini untuk mengidentifikasi perlakuan yang direkomendasikan dalam pembuatan kandidat wafer berdasarkan karakteristik fisis wafer. Kandidat wafer ditinjau berdasarkan warna, kadar air, densitas wafer, densitas partikel, dan porositas. Proses pembuatan wafer dilakukan dengan proses pemadatan dan pemanasan. Sebelum serbuk limbah tahu dicetak, dipastikan dahulu kadar air pada serbuk limbah tahu sesuai dengan stadar SNI 3148:2:200. Suhu pemanasan serbuk limbah tahu yang direkomendasikan menggunakan suhu 100oC. Karakteristik serbuk limbah tahu yang dihasilkan yaitu serbuk berwarna putih, kadar air sebesar 14,1% dengan nilai densitas partikel serbuk limbah tahu(𝜌sa ) 0,189g/cm3 serta porositas (𝜙sa ) 0,216%. Sedangkan untuk proses pencetakan wafer, suhu pemanasan yang direkomendasikan yaitu 70oC. Kandidat wafer yang diperoleh menghasilkan warna putih, tahan hingga 4 minggu, kadar air 7,19%, densitas partikel (𝜌p ) 0,254 g/cm3, densitas wafer 1,10 g/cm3 dan porositas 𝜙w sebesar 3,47±0,0118%.
Analisis Pembelajaran Daring di SD 2 Tenggeles Mejobo Kudus pada Masa Pandemi Covid-19
Authors: Kartika Muhammad , Erik Aditya Ismaya  , Muhammad Noor Ahsin  
Published: February 2021

Latar belakang dilakukannya penelitian ini adalah melihat dari latar belakang kendala pembelajaran daring yang dialami oleh siswa dan guru dalam melakukan pembelajaran daring selama pandemi Covid-19 di SD 2 Tenggeles. Penelitian ini bertujuan mendeskripsikan kendala pembelajaran daring yang dialami oleh siswa dan guru, dan mendeskripsikan solusi kendala pembelajaran daring di SD 2 Tenggeles pada masa pandemi Covid-19. Metode penelitian yang digunakan dalam penelitian ini adalah Kualitatif Deskriptif. Teknik pengumpulan data yang digunakan adalah dokumentasi, observasi dan wawancara. Hasil penelitian menunjukkan beberapa kendala yang dialami oleh siswa yaitu siswa merasa jenuh karena selalu belajar di rumah, siswa tidak pernah bertemu untuk belajar dengan temannya dan siswa merasa kurang paham dalam memahami materi pelajaran. Selain itu kendala yang dialami guru adalah guru merasa pembelajan kurang maksimal kerena guru tidak bisa menyampaikan meteri secara tatap muka dan guru tidak bisa melihat perkembangan siswa dalam menguasai materi pelajaran. Solusi dari kendala yang dialami oleh siswa adalah orang tua selain mengasuh dan menemani anak dalam belajar diharapkan juga menggantikan peran guru untuk mengajari anak dalam memahami materi pelajaran yang sulit dan siswa diharapkan untuk bisa belajar kelompok dengan teman agar tidak jenuh dalam belajar di rumah. Lalu solusi dari kendala yang di alami oleh guru adalah guru dapat menghimbau orang tua untuk membiarkan anak mengerjakan soal evaluasi agar dapat melihat kemampuan anak dalam menguasai materi pelajaran. Berdasarkan kendala yang dialami oleh guru dan siswa solusi dari permasalahan tersebut adalah melakukan pembelajaran berbasis Blended Learning atau pembelajaran yang mengkombinasikan pembelajaran tatap muka dengan pembelajaran berbasis komputer.