bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypofractionated Radiotherapy for Locally or Systemically Advanced Non-small Cell Lung Cancer
Authors: Zhang Jiajia , Qi Zi'ning , Han Dong , Chen Siying , Sun Jifeng , Wang Jun , Zhao Lujun , Liu Ningbo 
Published: February 2021

Abstract
Background: Palliative thoracic radiotherapy (RT) can improve local control and survival in patients with unresectable locally or systemically advanced non-small cell lung cancer (NSCLC), but the optimal RT dose has not been well-defined. We investigated the survival outcomes of patients with NSCLC who underwent hypofractionated radiotherapy (HFRT).Methods: We retrospectively investigated survival and adverse effects among 74 patients with locally or systemically advanced NSCLC who received HFRT (45 Gy/15 fractions) at our institution.Results: The median overall survival (OS) was 18.7 months, with 1- and 2-year OS rates of 65.9% and 33.9%, respectively. The median local progression-free survival (LPFS) was 7.2 months, with 1- and 2-year LPFS rates of 27.9% and 9.4%, respectively. Sixteen patients (21.6%) developed grade ≤2 pneumonitis and 14 (19%) developed grade ≤2 esophagitis; no grades ≥3 pneumonitis or esophagitis occurred.Conclusions: HFRT is safe, tolerable, and effective for patients with unresectable locally or systemically advanced NSCLC exhibiting poor prognostic factors.
Prospective Analysis of Myocardial Strain Through Evolution of Chagas Disease in the Hamster Animal Model
Authors: Ribeiro Fernando F.F. , Moreira Henrique T. , Barros-Filho Antônio C.L. , Tanaka Denise M , Fabricio Camila G. , Oliveira Luciano F.L. , Prado Cibele M , Simões Marcus V. , Schmidt André , Maciel Benedito Carlos , Marin-Neto José Antônio , Romano Minna Moreira Dias 
Published: February 2021

Abstract
Background: Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and functional ventricular parameters during Chagas disease (CD) natural history in an animal model. Methods: 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Echocardiography was performed before the infection (baseline), at 1month (acute phase), 4, 6 and 8 months (chronic phase) using Vevo 2100 (Fujifilm Inc.) ultrasound system. Left ventricular end-diastolic diameter (LVEDD), end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were evaluated. Tricuspid annular plane systolic excursion (TAPSE) was used to assess right ventricular function. At 8 months, animals were euthanized and LV myocardial samples were analyzed for quantitation of inflammation and fibrosis. Results: LVEF decreased over time in Chagas group and a difference from Control was detected at 6 months (p-value of groups#time interaction = 0.005). There was a pronounced decrease in GLS, GCS and TAPSE in Chagas group (p-value of groups#time interaction = 0.003 for GLS, < 0.001 for GCS and < 0.009 for TAPSE vs Control) since the first month. LVESD, LVEF and GLS were significantly correlated to the number of inflammatory cells (r= 0.41, p=0.046; r= -0.42, p=0.042; r=0.41, p=0.047) but not to fibrosis. Conclusions: In the Syrian hamster model of CD STE parameters (GLS and GCS) showed an early decrease. Changes in LVEF, LVESD and GLS were correlated to myocardial inflammation but not to fibrosis.
Ardisia Crenata Sims Var. Bicolor Physiological Attributes And Soil Physico-Chemical Properties Along An Altitudinal Gradient On The Gaoligong Mountain, Southwest China
Authors: Ai Xingmei , Li Yu , Xie Huan , Zhao Caibao 
Published: February 2021

Abstract
Aims This research investigated the acclimation of Ardisia crenata Sims var. bicolor at different elevations, and evaluated both soil and plant responses to altitude. Methods We collected rhizosphere soil and upper canopy leaves from this evergreen shrub during the plant blooming phase from six different altitudinal ranges on the Gaoligong Mountain. We measured soil nutrients and enzyme activities. Spectrophotometry was used to investigate twelve indicators of leaves, including the antioxidant enzyme activities.Results Soil physicochemical analysis showed that soil pH was negatively correlated with altitude and decreased with soil depth, whereas there were positive correlations between altitude and soil water content, organic matter, and soil nutrients, including organic carbon, total N, and total P. Total K at high elevations showed an increase with soil depth but not significant. Soil urease, saccharase, amylase, catalase, and peroxidase activities were significantly positively correlated with altitude and organic matter, and these enzymes were sensitive to environmental changes. In contrast, specific enzyme activity provided more ecological information and responded more clearly to altitudinal changes, thus playing a crucial role in the study of interactions between soil nutrients and enzymes. Ardisia crenata var. bicolor showed significant differences in physiological compounds (except for anthocyanin); the concentrations of all compounds increased with altitude. Conclusions Our results indicate that plant-soil interactions with elevation changes significantly affect plant distribution and restrict plant growth and reproduction, which contribute to an understanding of the habitat and physiological characteristics and provide a theoretical basis for the effective cultivation and management of this species.
Combined Metabolomics and Machine Learning Algorithms to Explore Metabolic Biomarkers for Diagnosis of Acute Myocardial Ischemia
Authors: Cao Jie , Li Jian , Gu Zhen , Niu Jia-jia , An Guo-shuai , Du Qiu-xiang , Yun Ke-ming , Wang Ying-yuan , Huang Ping , Sun Jun-hong 
Published: February 2021

Abstract
Background: Acute myocardial ischemia (AMI) remains the leading cause of death worldwide. In particular, when death occurs within a short time, it is hard to find post-mortem specific structural anomalies of the heart at autopsy with standard methods. Therefore, the post-mortem diagnosis of AMI represents a current challenge for both clinical and forensic pathologists. Metabolomics technology plays an important role in searching for new diagnostic biomarkers. Here, we characterize metabolic profiles of AMI and attempted to interpret the role of metabolic changes in sudden cardiac death (SCD).Methods: The untargeted metabolomics was applied to analyze serum metabolic signatures from AMI experimental group (ligation of left coronary artery at 5mm below the left atrial appendage in rats), along with the control and sham groups (n = 10 per group). The analytical strategy based on ultra performance liquid chromatography combined with high-resolution mass spectrometry. The resulting data was preprocessed to discriminant metabolites, and a set of machine learning algorithms were used to construct predictable models. Seventeen blood samples from autopsy cases were applied to validate the classification model's value in human samples.Results: A total of 28 endogenous metabolites in serum were significantly altered in AMI group relative to control and sham groups. Gradient tree boosting, support vector machines, random forests, logistic regression, and multilayer perceptron models were used to further screen the more valuable metabolites from 28 metabolites to optimize the biomarker panel. The results showed that classification accuracy and performance of multilayer perceptron (MLP) models were better than other algorithms when the metabolites consisting of L-threonic acid, N-acetyl-L-cysteine, CMPF, glycocholic acid, L-tyrosine, cholic acid, and glycoursodeoxycholic acid. In autopsy cases, the MLP model constructed based on rat dataset achieved an accuracy of 88.23, and ROC of 0.89 for predicting AMI-SCD.Conclusions: A panel of 7 molecular biomarkers was identified by assessment the accuracy and efficacy of different metabolite combinations in inferring AMI using machine learning algorithms. The constructed MLP model has a high diagnostic performance for both AMI rats and autopsies-based blood samples. Thus, the combination of metabolomics and machine learning algorithms provides a novel strategy for AMI diagnosis.
How to Disseminate National Recommendations for Physical Activity: a Qualitative Analysis of Critical Change Agents in Germany
Authors: Wolbring Laura , Reimers Anne Kerstin , Niessner Claudia , Demetriou Yolanda , Schmidt Steffen Christian Ekkehard , Woll Alexander , Wäsche Hagen 
Published: February 2021

Abstract
Background: Physical activity recommendations are only reached by a small part of the population. A common problem is that research findings on public health-related topics such as physical activity promotion are oftentimes not translated into practice. The involvement of relevant stakeholders, such as change agents (role models, decision-makers, and/or knowledge mediators), is a common strategy to implement physical activity recommendations in specific settings as they have the necessary knowledge of contextual factors. However, dissemination and implementation of physical activity recommendations are often prevented by focusing exclusively on the health sector and by underestimating the individual perceptions and needs of change agents. Therefore, the purpose of this study is to address the problem of how physical activity recommendations can be translated into practice through comprehensive consideration of the situation and context of change agents from various sectors of society at different administrative levels. The survey of change agents allows for deriving recommendations for action on how a national dissemination strategy of physical activity recommendations should be designed.Methods: Qualitative expert interviews were conducted with change agents from different sectors of society and administrative levels (N = 21). The interviews were recorded, transcribed verbatim, and analyzed by two trained researchers using qualitative content analysis. Results: The change agents’ perceived relevance of physical activity and physical activity promotion as well as their knowledge of physical activity recommendations varied across different sectors of society. Nine themes were identified covering the change agents’ needs for the implementation of physical activity recommendations: Strengthening of political will and cooperation, availability of public space for physical activity, change of awareness and health education, professional qualification, financial incentives, development of physical activity promoting programs and structures, provision of resources, bridging the theory-practice gap, and knowledge of physical activity recommendations.Conclusions: This exploratory study contributes to the development of an evidence-based dissemination strategy of physical activity recommendations involving change agents from various sectors. Cross-sectoral needs and obstacles were identified indicating gaps that have to be addressed. Future research should choose practice-oriented approaches to develop dissemination strategies that are adapted to the needs of local contexts.
Enhanced Photocatalytic Activity and Magnetic Properties of CNTs/Sn-doped Co3O4 Nanocomposite
Authors: Kazazi Mahdi , Norouzi Mahdi , Moradi Banafsheh 
Published: February 2021

Abstract
Photocatalysis is a green technology which transforms available photon energy into useful chemical energy. The reaction mechanism is based on the ability to create electron-hole pairs under appropriate light. Semiconductors have attracted great attention in photocatalysts because of their high photosensitivity. Spinel–type cobalt oxide nanorods have been prepared by a simple hydrothermal method using cobalt nitrate as precursor. Sn-doped Co3O4 was composited with carbon nanotubes for better photocatalytic activity. An extensive characterization of the prepared samples was carried out using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometer (VSM) and UV–Visible absorption spectroscopy. The XRD results show the formation of Co3O4 phase with FCC structure, FESEM confirms the nanorods morphology of the cobalt oxide and the VSM taken at room temperature shows an antiferromagnetic behavior. The investigation of photocatalytic activity of Co3O4 based was done by methyl orange dye. At the end, the responsible mechanism of CNT/Sn-CO was discussed.
Mechanical aspects of construction of new TBM tunnel under existing structures
Authors: Ke Wu , Zhang Zheng , Li Chen Shu , Zhou Sheng Lei , Zhao Hui Jia , Zheng Yang 
Published: February 2021

Abstract
It is inevitable for the construction of subways to pass under the existing structures in the city; this will cause settlement of the existing structures and affect their safety. The soil is a complex mixture, and hence it is difficult to determine the damage caused by construction using tunnel boring machine (TBM) method to the stress balance of the surrounding soil. Normally, settlement and uplift of the surface are caused during tunneling. Therefore, large-scale 3D simulations are needed to study the interaction between mechanically driven tunnel construction and the surrounding soil to estimate the expected settlement and related damage risks to the existing structures, especially in tunnel construction in urban areas. Qingdao Metro Line 1 in the Haixiao section (Xiaocunzhuang and Haiboqiao stations) was taken up as the research object to study the trend and degree of the effect of TBM tunnel construction using the numerical simulation software Midas GTS NX. The numerical simulation results and measured data were used for the reliability analysis to study the influence of different digging speeds and pressures in TBM construction on ground subsidence, and the effect of vibrations generated at the tunnel face by the TBM cutter head on the ground structure. It is shown that when other factors remain unchanged, the faster the driving speed, the smaller the ground settlement; the higher the surrounding rock pressure, the smaller the ground settlement. The vibration of the ground structure caused by the TBM cutter head complies with the relevant specifications. During construction, the driving parameters should be selected suitably depending on the available budget.
Clinical Analysis of Metagenomic Next-generation Sequencing Confirmed Chlamydia psittaci Pneumonia: A Case Series and Literature Review
Authors: Teng Xin-Qi , Gong Wen-Cheng , Qi Ting-Ting , Li Guo-Hua , Qu Qiang , Lu Qiong , Qu Jian 
Published: February 2021

Abstract
Introduction: Chlamydia psittaci infection is a zoonotic infectious disease, which mainly inhaled through the lungs when exposed to the secretions of poultry that carry pathogenic bacteria. The traditional respiratory specimens or serological antibody testing is slow and the false-negative rate is high. Metagenomic next-generation sequencing gives a promising rapid diagnosis tool. Methods: We retrospective summarized the clinical characteristics of five C. psittaci pneumonia patients diagnosed by mNGS, conducted a literature review summarizing the clinical characteristics of patients with C. psittaci pneumonia reported since 2010.Results: Five C. psittaci. pneumonia patients confirmed by mNGS aged from 36 to 66 years with three males. 60% of patients had type 2 diabetes mellitus. And 60% of patients had a history of contact with avian or poultry. All patients had a high fever over 38.5 °C, cough, hypodynamia, hypoxemia, and dyspnea on admission. Two patients had invasive ventilator support and Extracorporeal Membrane Oxygenation support. The levels of C-reactive protein, procalcitonin, and erythrocyte sedimentation rate on admission and follow-up were all higher than normal values. Doxycycline or moxifloxacin monotherapy was accounted for 1/5 (20%) and 2/5 (40%) patients, and combination therapy was accounted for 2/5(40%) patients. Four patients improved and were discharged, and one patient died due to multiple organ failure and disseminated intravascular coagulation.Conclusions: mNGS can increase the detection rate of C. psittaci, shorten the diagnosis time of C. psittaci pneumonia and improve the prognosis of patients.
Hybrid Raman-Erbium Random Fiber Laser with a Half Open Cavity Assisted by Artificially Controlled Backscattering Fiber Reflectors
Authors: Perez-Herrera R. A. , Roldan-Varona P. , Galarza M. , Sañudo-Lasagabaster S. , Rodriguez-Cobo L. , Lopez-Higuera J. M. , Lopez-Amo M. 
Published: February 2021

Abstract
A hybrid Raman-erbium random fiber laser (RFL) with a half-open cavity assisted by chirped artificially controlled backscattering fiber reflectors (ACBFRs) is presented. A combination of 2.4 km of dispersion compensating fiber (DCF) with two highly erbium-doped fiber (EDF) pieces of 5 m length was used as gain medium. A single random laser emission line centered at 1553.8 nm with an output power level of -6.5 dBm and an optical signal to noise ratio (OSNR) of 47 dB was obtained when pumped at 37.5 dBm. A full width at half maximum (FHWM) of 1 nm and a 100% confidence level (CL) output power instability as low as 0.08 dB were measured. The utilization of the new laser cavity as a temperature and strain sensor is also experimentally studied.
FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T cell lymphoma, not otherwise specified
Authors: Debackere Koen , Marcelis Lukas , Demeyer Sofie , Bempt Marlies Vanden , Mentens Nicole , Gielen Olga , Jacobs Kris , Broux Michael , Verhoef Gregor , Michaux Lucienne , Graux Carlos , Wlodarska Iwona , Gaulard Philippe , de Leval Laurence , Tousseyn Thomas , Cools Jan , Dierickx Daan 
Published: February 2021

Abstract
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we performed RNA-sequencing of 18 cases and validated results in an independent cohort of 37 PTCL cases. We identified FYN-TRAF3IP2, KHDRBS1-LCK and SIN3A-FOXO1 as new in-frame fusion transcripts, with FYN-TRAF3IP2 as a recurrent fusion detected in 8 of 55 cases. Using ex vivo and in vivo experiments, we demonstrate that FYN-TRAF3IP2 and KHDRBS1-LCK activate signaling pathways downstream of the T cell receptor (TCR) complex and confer therapeutic vulnerability to clinically available drugs.
EVALUATING QUALITY OF LIFE IN FAMILIES WITH WILLIAMS SYNDROME PATIENTS
Authors: Sepúlveda Esther Moraleda , Arana-Zumaquero Mario , López-Resa Patricia 
Published: February 2021

Abstract
Background: Williams Syndrome is a developmental disorder characterized by a variable intellectual disability. People with Williams Syndrome need the intervention of several clinical and educational specialists throughout their life. However, little is known about the impact produced by this disability in their immediate environment, especially in families. The purpose was to know the level of quality of life described by families with Williams Syndrome. Methods: The sample was made up of 33 families belong to Spanish Williams Syndrome Association who were evaluated using the Kidslife Scale. Their children and adolescents were between 4 and 20 years old. Eight main quality of life domains were evaluated: emotional well-being, physical well-being, material well-being, personal development, interpersonal relations, social inclusion, self-determination and rightsResults: The obtained data indicated that the degree and presence of intellectual disability did not homogeneously influence people’s quality of life, but many variables could alter their quality of life to a greater or lesser extent. There are no significant differences between quality of life areas but significant differences appeared for level of dependence in the self-determination subarea (p<.05). Conclusions: These results led us to analyse the social and emotional implications for families and their environment.
Critical incidents in anorexia nervosa: perspectives of those with a lived experience
Authors: Leppanen Jenni , Tosunlar Lara , Blackburn Rachael , Williams Steven , Tchanturia Kate , Sedgewick Felicity 
Published: February 2021

Abstract
Background: Although social-emotional difficulties are believed play a key role in anorexia nervosa (AN), there is uncertainty regarding what these difficulties might look like. Previous research has largely focused on a “disease model” of social-emotional processing in AN with little attention paid to positive emotions and experiences. Therefore, the aim of the present study was to obtain a fuller picture of critical life events as identified by those with lived AN experience.Methods: Thirty-four participants aged 16-48 with current or past AN completed an online survey describing self-defined positive and difficult critical events. Thematic analysis was used to assess patterns in participants narrative responses.Results: Two major themes were identified in the descriptions of positive critical events: Moments of celebration and Unexpected positive outcomes. These major themes revealed increased external focus and some corrective experiences. Difficult events clustered into life events that were identified as Eating disorder (ED) related and Non-ED related and included the dimensions of relational conflict and feeling unsupported.Discussion: The findings suggest that although negative emotionality was identified in the accounts of those with lived experience of AN capacity for “big-picture” thinking with and explicit focus on others was also identified. Moreover, an openness to corrective experiences that worked to challenge negative expectations was evident for some participants. Together these findings have scope as targets for further clinical research and treatment interventions.