bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reverse hybrid therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis
Authors: Hu Yi , Ouyang Yaobin , Zhu Yin , Lu Nong‐Hua 
Published: February 2021

ABSTRACTBackgroundThe efficacy and safety of reverse hybrid therapy in the treatment of Helicobacter pylori (H. pylori) infection remained unclear.Materials and MethodsThis systematic review was performed in accordance with the PRISMA 2009 guidelines. A systematic search of the Pubmed, Embase, and Cochrane database was conducted using the combination of “Helicobacter pylori or H. pylori or Hp” and “hybrid”. The primary endpoint of this meta‐analysis was to evaluate the efficacy of reverse hybrid therapy; the second endpoint was to evaluate the efficacy of reverse hybrid therapy among the strains with antibiotic resistance and the compliance, safety of reverse hybrid therapy.ResultsFour studies with 1530 participants were included. The crude H. pylori eradication rate of reverse hybrid therapy was 95.5% (737/772) and 96.2% (701/729) by ITT and PP analysis, respectively. There is no statistical significance of efficacy between reverse hybrid therapy and control according to ITT (pooled rate: 96% vs. 94%, RR = 1.02, 95% CI, 0.95–1.05, p = .28) and PP (pooled rate: 96% vs. 94%, RR = 1.02, 95% CI, 0.99–1.06, p = .23) analysis. The effect of reverse hybrid therapy in strains with isolated clarithromycin resistance (pooled rate: 89% vs. 65%, RR = 1.13, 95% CI, 0.77–1.66, p = .53), metronidazole resistance (pooled rate: 91% vs. 81%, RR = 1.00, 95% CI, 0.96–1.05, p = .85), and dual clarithromycin‐metronidazole resistance (pooled rate: 86% vs. 83%, RR = 0.94, 95% CI, 0.69–1.27, p = .69) showed no superior to that of control. The compliance of reverse hybrid therapy is 96%, and side effect is slightly lower to that of control group.ConclusionReverse hybrid therapy shows good efficacy, safety, and compliance in the treatment of H. pylori infection. However, its application for H. pylori treatment in regions with high antibiotic resistance need to be further explored.
Physicochemical and emulsifying properties of whey protein isolate (WPI)‐polydextrose conjugates prepared via Maillard reaction
Authors: Liu Hui , Zhu Xiaofei , Jiang Yang , Sun‐Waterhouse Dongxiao , Huang Qingrong , Li Feng , Li Dapeng 
Published: February 2021

SummaryIn this study, whey protein isolate (WPI) and polydextrose (PDX) were used to produce WPI‐PDX covalent conjugates via dry‐heating Maillard reaction, and their characteristics and functional properties including abilities to emulsify and stabilise the corn germ oil/water emulsions were measured. Compared with WPI alone, the WPI‐PDX conjugates had higher water solubility and DPPH radical scavenging ability, and the derived emulsions exhibited good storage stability over 60 days prepared under these conditions: reaction time 24 h, conjugate concentration 4–6%, oil fraction ratio 0.6 and emulsion system pH 3–8. Further, we found that the emulsion possessed the best storage stability under the condition of 4% WPI‐PDX conjugates and 0.6% oil fraction. These results provide a potent to prepare a beneficial Maillard conjugation following an optimised reaction condition and highlight the potential use of WPI‐PDX conjugates as the emulsifier in food industry.
Onward migration and intra‐European mobilities: A critical and theoretical overview
Authors: Della Puppa Francesco , Montagna Nicola , Kofman Eleonore 
Published: February 2021

AbstractThis paper aims to give a theoretical introduction on onward migration and provide a review of empirical research on this topic in the EU. While there is a growing body of work on the topic, this still remains an under‐researched phenomenon. Existing studies have looked at different, often overlapping, dimensions of onward migration and how it may be an effect of mobility capital or influenced by variables as diverse as economic crises, gender, country of origin, age and skills. In this article, we proceed by isolating some of these variables and identify common issues across research. The first section provides some defining points and conceptualizes different types of onward movement. The second section focuses on different dimensions of onward migration and highlights some key areas examined by research such as push and pull factors, different forms of capital including the role of EU citizenship and the economic crisis of 2008.
Effects of allogenic acellular dermal matrix combined with autologous razor‐thin graft on hand appearance and function of patients with extensive burn combined with deep hand burn
Authors: Shang Feng , Hou Qiang 
Published: February 2021

AbstractThe aim of the study was to observe the effect of allogeneic acellular dermal matrix (ADM) combined with autologous razor‐thin graft on the appearance and function of hands in patients with extremely large area burns combined with deep hand burns. Sixty‐four patients with severe burn combined with deep burn of the hand in our hospital from August 2015 to August 2019 were selected as the study subjects. All patients were randomly divided into the study group (32 cases, given allogeneic ADM combined with autologous razor‐thin graft) and the control group (32 cases, given autologous scar tissue combined with autologous razor‐thin graft). Hand appearance, wound healing, wound contraction, hand function, and quality of life were compared between the two groups at 3 and 6 months after treatment. The vascular distribution, skin thickness, and flexibility scores of the two groups 6 months post operation were lower than those of the 3 months post operation (P < .05). At 6 months after operation, there were significant differences in blood vessel distribution, skin thickness, flexibility, and colour between the two groups (P < .05). The wound healing rate and wound contraction rate of the two groups at 6 months after operation were higher than those at 3 months after operation (P < .05). The wound healing rate of the study group was higher than that of the control group (P < .05), but there was no significant difference in the wound contraction rate between the two groups. Hand function was better in both groups 6 months after operation than 3 months after operation (P < .05). The hand function of the experimental group was better than that of the control group at 3 and 6 months after operation (P < .05). The quality of life in the two groups at 6 months after operation was significantly higher than that at 3 months after operation, and the quality of life in the study group was consistently higher than that in the control group (P < .05). Allogeneic ADM combined with razor‐thin graft in the treatment of patients with extensive burns and deep hand burns can effectively restore the shape and function of the hand, which is conducive to wound healing and improve the quality of life of patients, and it is worthy of wide clinical application.
Inequities in diagnosis of Fragile X syndrome in Colombia
Authors: Saldarriaga‐Gil Wilmar , Cabal‐Herrera Ana Maria , Fandiño‐Losada Andrés , Vásquez Andrés , Hagerman Randi , Tassone Flora 
Published: February 2021

AbstractBackgroundFragile X syndrome (FXS) is the most common cause of inherited intellectual disability and autism spectrum disorder (ASD). In Colombia, there are no screening or testing protocols established for the diagnosis of FXS. In this study, we aimed to describe the diagnostic trends of FXS in Colombia.MethodsData were included on 1322 individuals obtained based on data from the only 2 databases available. Sociodemographic information and data related to the diagnostic process were obtained and included in this study.ResultsThe average age at the time of diagnosis for individuals with the full mutation (FM) was of 26.9 ± 2.57 years and was strongly dependent on sex and socioeconomic status. Most individuals with a molecular diagnosis were from the main cities.ConclusionThe overall age of diagnosis of FXS is later in life than reports from other countries. Restricted access to molecular testing through the national health system might explain this discrepancy in Colombia.
Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
Authors: Mulè’ Giuseppe , Sorce Alessandra , Vario Maria Giovanna , Giambrone Marta , Cottone Santina 
Published: February 2021

AbstractIt has long been known that blood pressure (BP) is characterized by marked short‐term fluctuations occurring within a 24‐h period and also by long‐term oscillations occurring over more prolonged periods of time. An increased short‐term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24‐h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short‐term BPV and the need for its control by treatment, evidence is still needed from intervention trials aimed at demonstrating that by reducing BPV through administration of antihypertensive drugs, a reduction in organ damage and in the rate of cardiovascular events can be obtained.
AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells
Authors: Zou Junrong , Li Cong , Jiang Shanshan , Luo Lingyu , Yan Xiaohua , Huang Deqiang , Luo Zhijun 
Published: February 2021

AbstractWe have previously shown that adenine monophosphate‐activated protein kinase (AMPK) regulates transforming growth factor β (TGF‐β)‐triggered Smad3 phosphorylation. Here we report that AMPK inhibits TGF‐β1 production. First, metformin reduced mRNA levels of TGF‐β1 in gastric cancer cells, in parallel to the decrease of its protein abundance. The effects were more prominent in the cells containing LKB1, an upstream kinase of AMPK. Second, knockdown of Smad3 by siRNA abrogated the expression of TGF‐β1. Third, metformin suppressed firefly luciferase activity whose transcription was driven by TGF‐β1 promoter. In accordance, deletion of the putative binding site of Smad3 in the TGF‐β1 promoter region severely impaired the promoter activity and response to metformin. Fourth, in support of our in vitro study, clinical treatment of type 2 diabetes with metformin significantly reduced the plasma level of TGF‐β1. Finally, immunohistochemical studies revealed that TGF‐β1 was highly expressed in human gastric cancer tissues as compared with adjacent normal tissues. In contrast, p‐AMPK exhibited opposite changes. Furthermore, the survival rate of gastric cancer patients was positively correlated with p‐AMPK and negative with TGF‐β1. Therefore, our present studies depict a mechanism underlying AMPK suppression of TGF‐β1 autoinduction, which is mediated through inhibition of Smad3 phosphorylation and activation. Collectively, our study sheds a light on the potential usage of AMPK activators in the treatment of TGF‐β1‐mediated gastric cancer progression.
Prospective impact of COVID‐19 on mental health functioning in adolescents with and without ADHD: protective role of emotion regulation abilities
Authors: Breaux Rosanna , Dvorsky Melissa R. , Marsh Nicholas P. , Green Cathrin D. , Cash Annah R. , Shroff Delshad M. , Buchen Natalie , Langberg Joshua M. , Becker Stephen P. 
Published: February 2021

BackgroundThe impact of chronic stressors like the COVID‐19 pandemic is likely to be magnified in adolescents with pre‐existing mental health risk, such as attention‐deficit/hyperactivity disorder (ADHD). This study examined changes in and predictors of adolescent mental health from before to during the COVID‐19 pandemic in the Southeastern and Midwestern United States.MethodsParticipants include 238 adolescents (132 males; ages 15–17; 118 with ADHD). Parents and adolescents provided ratings of mental health symptoms shortly before the COVID‐19 pandemic and in spring and summer 2020.ResultsAdolescents on average experienced an increase in depression, anxiety, sluggish cognitive tempo, inattentive, and oppositional/defiant symptoms from pre‐COVID‐19 to spring 2020; however, with the exception of inattention, these symptoms decreased from spring to summer 2020. Adolescents with ADHD were more likely than adolescents without ADHD to experience an increase in inattentive, hyperactive/impulsive, and oppositional/defiant symptoms. Adolescents with poorer pre‐COVID‐19 emotion regulation abilities were at‐risk for experiencing increases in all mental health symptoms relative to adolescents with better pre‐COVID‐19 emotion regulation abilities. Interactive risk based on ADHD status and pre‐COVID‐19 emotion regulation abilities was found for inattention and hyperactivity/impulsivity, such that adolescents with ADHD and poor pre‐COVID‐19 emotion regulation displayed the highest symptomatology across timepoints. Lower family income related to increases in inattention but higher family income related to increases in oppositional/defiant symptoms.ConclusionsThe early observed increases in adolescent mental health symptoms during the COVID‐19 pandemic do not on average appear to be sustained following the lift of stay‐at‐home orders, though studies evaluating mental health across longer periods of time are needed. Emotion dysregulation and ADHD increase risk for sustained negative mental health functioning and highlight the need for interventions for these populations during chronic stressors. Results and clinical implications should be considered within the context of our predominately White, middle class sample.
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 2: specific clinical and comorbid situations
Authors: Nast A. , Smith C. , Spuls P.I. , Avila Valle G. , Bata‐Csörgö Z. , Boonen H. , De Jong E. , Garcia‐Doval I. , Gisondi P. , Kaur‐Knudsen D. , Mahil S. , Mälkönen T. , Maul J.T. , Mburu S. , Mrowietz U. , Reich K. , Remenyik E. , Rønholt K.M. , Sator P.G. , Schmitt‐Egenolf M. , Sikora M. , Strömer K. , Sundnes O. , Trigos D. , Van Der Kraaij G. , Yawalkar N. , Dressler C. 
Published: February 2021

AbstractThis evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following the EuroGuiDerm Guideline and Consensus Statement Development Manual. The second part of the guideline provides guidance for specific clinical and comorbid situations such as treating psoriasis vulgaris patient with concomitant psoriatic arthritis, concomitant inflammatory bowel disease, a history of malignancies or a history of depression or suicidal ideation. It further holds recommendations for concomitant diabetes, viral hepatitis, disease affecting the heart or the kidneys as well as concomitant neurological disease. Advice on how to screen for tuberculosis and recommendations on how to manage patients with a positive tuberculosis test result are given. It further covers treatment for pregnant women or patients with a wish for a child in the near future. Information on vaccination, immunogenicity and systemic treatment during the COVID‐19 pandemic is also provided.
Desmoplastic melanoma: a review of its pathology and clinical behaviour, and of management recommendations in published guidelines
Authors: Hughes T.M. , Williams G.J. , Gyorki D.E. , Kelly J.W. , Stretch J.R. , Varey A.H.R. , Hong A.M. , Scolyer R.A. , Thompson J.F. 
Published: February 2021

AbstractDesmoplastic melanomas are uncommon. Their behaviour differs from that of other melanoma subtypes; therefore, management guidelines for non‐desmoplastic melanomas may not be applicable. This review sought to examine all available evidence relating to the behaviour and management of desmoplastic melanomas, based on review of all relevant English‐language publications, and to critically assess the recommendations for their management in current published melanoma management guidelines. Compared with other melanoma subtypes, patients with ‘pure’ desmoplastic melanomas (where ≥90% of the invasive melanoma is of desmoplastic melanoma subtype) have much lower rates of sentinel node positivity and distant metastasis. Local recurrence rates are higher for desmoplastic melanomas, but resection margins wider than those recommended for non‐desmoplastic melanomas have not been shown to be of benefit. Adjuvant radiotherapy reduces the risk of local recurrence when a satisfactory histological clearance (≥8 mm) cannot be achieved. Of 29 published melanoma management guidelines identified, only 11 specified management for desmoplastic melanomas, while seven simply stated that the feature should be reported. Desmoplastic melanoma is a unique melanoma subtype with biology that differs from that of other melanoma subtypes. It requires specific management strategies but few current guidelines address these.
Intermediation in a directed search model
Authors: Kultti Klaus , Takalo Tuomas , Vähämaa Oskari 
Published: February 2021

AbstractWe provide an example where establishing competitive coordination service platforms is so lucrative that they end up reducing welfare. We consider a canonical directed search model in which buyers have unit demands and sellers' capacity constraint leads to a coordination problem: in a symmetric equilibrium without intermediation some sellers receive too many and some too few buyers. We compare this equilibrium to one where sellers and buyers can choose to become intermediaries who coordinate the meetings. In this setup, roughly one‐fifth of agents become intermediaries. As a result, a large part of the supply and demand in the economy vanishes. Moreover, the large amount of intermediaries actually reduces the meeting efficiency. Jointly, these effects imply that the gains from trade are lower than that in the economy without intermediation.
The Effectiveness of Bereavement Support for Adult Family Caregivers in Palliative Care: A Meta‐Analysis of Randomized Controlled Trials
Authors: Kustanti Christina Yeni , Fang Hui‐Fen , Linda Kang Xiao , Chiou Jeng‐Fong , Wu Shen‐Chi , Yunitri Ninik , Chu Hsin , Chou Kuei‐Ru 
Published: February 2021

AbstractPurposeThis meta‐analysis aimed to summarize and synthesize the effectiveness of bereavement support for adult family caregivers in palliative care.MethodsMeta‐analysis was conducted. The databases of the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane, Embase, Medline, PubMed, Scopus, and Web of Science were comprehensively searched from inception until January 2020. This study followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and standard methods for conducting a meta‐analysis. Data analysis was performed using Comprehensive Meta‐analysis version 3.0, and the random‐effects model was adopted.FindingsIn total, 19 randomized controlled trials with an overall sample size of 2,690 participants met the inclusion criteria. The study showed that bereavement support had a significant effect on reducing grief (Hedges’ g score = ‐0.198; 95% confidence interval [CI] ‐0.310 to ‐0.087), depression (Hedges’ g score = ‐0.252; 95% CI ‐0.406 to ‐0.098), and anxiety (Hedges’ g score = ‐0.153; 95% CI ‐0.283 to ‐0.023); however, high heterogeneity was present. No statistically significant difference was shown for traumatic feelings. Based on moderator analysis, a group format was more effective for grief, a combined individual and group format for depression, and an individual format for anxiety. Bereavement support was more effective when delivered by professionals, when delivered in more than six sessions, and need to be evaluated within 6 months.ConclusionsBereavement support was effective in reducing grief, depression, and anxiety. The majority of the included studies had moderate heterogeneity, which limited the comparability of the evidence. Therefore, more robust randomized controlled trials are needed to confirm these study results.Clinical RelevanceThis meta‐analysis provides evidence that bereavement support delivered in the palliative care setting is effective for reducing grief, depression, and anxiety. Nurses and other healthcare professionals can make recommendations for adult family caregivers based on this study in reducing psychological symptoms due to a loss in the palliative care domain.
Ten statements to support nurse leaders implement e‐health tools for nursing work in hospitals: A modified Delphi study
Authors: Bail Kasia , Merrick Eamon , Fox Amanda , Gibson Jo , Hind Alicia , Moss Cameron , Strickland Karen , Redley Bernice 
Published: February 2021

AbstractAimTo use expert consensus to develop guidance for nurse leaders implementing e‐health tools to support nursing work in hospitals.BackgroundNurse leaders are increasingly required to make decisions about the selection, development, implementation and optimisation of e‐health tools for nursing work in hospitals. Guidance in this rapidly evolving and complex space is limited.DesignA two‐phase modified Delphi study.MethodsPhase one involved in‐depth interviews with five nursing informatics experts. Analysis used the qualitative framework method, informed by the Theoretical Domains Framework (TDF), to develop statements for an anonymous online Delphi scoring survey. This was distributed using snowball sampling methods to Australian nurse informatics leaders and experts. Final analysis involved synthesis of qualitative and quantitative data. The study adheres to the COnsolidated criteria for REporting Qualitative research (COREQ) checklist.ResultsTen guidance statements to support nurse leaders to implement e‐health tools in hospitals were developed from the synthesis of qualitative interview data and 29 experts’ responses to the 55‐item Delphi response survey.ConclusionImplementation of e‐health tools for nursing work is complex in health settings and requires careful examination of multiple factors and interactions between clinicians, tools, service users and the health organisation. This research proposes ten statements to support nurse leaders with decisions about implementing e‐health tools to support nursing work in hospitals.Relevance to clinical practiceThe ten statements developed by this research provide a resource to assist policy and practice decisions about e‐tools to ensure they are suited to supporting nursing work. Nurse leaders can use the ten statements for guidance in the selection, development, implementation and optimisation of e‐health tools to ensure suitability and adaptation for nursing work in hospitals.