bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Smart System for Health Caregiver Based on IoMT: Toward Tele-Health Caregiving
Authors: Abdulbaqi Azmi Shawkat , Obaid Ahmed J. , Hmeed Alazawi Sundos Abdulameer 
Published: July 2021

This manuscript introduces the designing and emulation of a wireless, intelligent health surveillance device based on the internet of medical things, with GSM alert technology by health caregivers. In hospitals or medical centers where the body temperature of the patient needs to be constantly checked or other vital signs have to be checked, this is normally achieved by a specialist or another paramedicine personnel by continuously checking the temperature, pulse rate and keeping records of these arguments. This approach is really repetitive and can be very tiring, especially in medical centers crowded with patients. The main system task is to surveillance the patient's body pulse rate and the patient's body temperature and sending the information to the specialists wirelessly via the liquid crystal display. The transmitting unit of this suggested system continuously surveillance the patient's body temperature, as well as the heart rate with digital sensors, and ultimately, displays the outcomes on the liquid crystal display transmitter to present to the specialists. The receiver device is placed in the specialist chamber for continuous wireless surveillance of the patient's body temperature and heart rate. At the receiver end where the specialist will be, an alarm is often triggered and triggered When the patient's heart rate or temperature is below/above the normal human threshold of 37 ° C and 70 beats/min (bpm), then, send an SMS to the specialist if he or she is absent as a means of continuous update. The suggested framework was implemented utilizing Proteus Tools and programs, composed in Embedded C. The obtained outcomes indicate an effective way to relay details on duty to the specialists for urgent patient care.
1981 – « A New C.A.R. for ESP Teachers : Quelques modestes propositions pour la recherche assistée par ordinateur »
Authors: Pradeilles Anne 
Published: July 2021

En C.A.E., Computer-Assisted Education, ou C.A.I., Computer-Assisted Instruction, on parle parfois de C.A.T.s (Computer-Assisted Teachers). Pourquoi nous autres CATs, ou futurs CATs, nous priverions-nous de ce nouveau moyen de progression qu’est la recherche assistée par ordinateur ou C.A.R. (Computer-Assisted Research) ? Au delà du jeu de mots, un vaste champs d’investigation s’ouvre à nous. Le 29 Mai 1981, au 2e Congrès Annuel de l’APLIUT, à Sèvres, au cours de la journée d’études des enseignants d’anglais des départements Informatique des IUT, Madame le Professeur J. Gallais-Homonno, directeur de la section langue d’Anglais de l’université de Metz, a fait une conférence intitulée « L’ordinateur et Les Langues de Spécialités ».
1985 – « L'offre d'emploi technique : présentation d'une enquête sur les besoins langagiers en anglais tels qu'exprimés par l'industrie dans les annonces de presse »
Authors: Durand Gilles 
Published: July 2021

Présentation d’une enquête sur les besoins langagiers en anglais tels qu’exprimés par l’industrie dans les annonces de presse. Cet article se divise en deux parties. La première est l’étude de 102 offres d’emplois techniques dont le but est de définir les capacités langagières de base exigées des postulants. Dans une seconde partie, l’examen de 23 réponses d’entreprises se propose de vérifier cette approche. L’accent porte également sur la définition de directions d’enseignement adaptées à l’enseignement des langues de spécialités.
2014 - « Quelle grammaire pour le LANSAD ? De l’enseignement de la langue à l’apprentissage du discours : éléments pour l’acquisition de l’interaction verbale »
Authors: Rouveyrol Laurent 
Published: July 2021

Ce travail traite du rapport que la grammaire peut/doit entretenir avec le public LANSAD. Nous partons du principe que ce qui doit désormais être acquis, c’est la capacité à interagir avec autrui, à argumenter, à agir sur les systèmes de valeur et les représentations : on passe de l’enseignement de la langue et de sa grammaire à l’acquisition du discours. Comment favoriser une telle acquisition ? La première étape consiste à étudier les débats authentiques pour déterminer quelles stratégies sont adoptées par les locuteurs natifs pour gérer les contraintes du genre ; nous prendrons le débat Question Time pour corpus. La deuxième étape a pour objet de faire prendre conscience aux apprenants de l’existence de ces stratégies, culturellement marquées. Nous nous demandons ensuite quel parcours didactique mettre en place. De façon plus large, il est question ici de déterminer l’apport de l’analyse de discours pour favoriser l’acquisition de certaines compétences langagières inhérentes à l’interaction sociale dans le monde contemporain.
Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28–Stimulated T Cell IFN-γ and TNF-α Production
Authors: Calianese David , Kreiss Tamara , Kasikara Canan , Davra Viralkumar , Lahey Kevin C , Gadiyar Varsha , Geng Ke , Singh Sukhwinder , Honnen William , Jaijyan Dabbu Kumar , Reichman Charles , Siekierka John , Gennaro Maria Laura , Kotenko Sergei V , Ucker David S , Brekken Rolf A , Pinter Abraham , Birge Raymond B , Choudhary Alok 
Published: July 2021

Abstract
Phosphatidylserine (PS)-targeting monoclonal Abs (mAbs) that directly target PS and target PS via β2-gp1 (β2GP1) have been in preclinical and clinical development for over 10 y for the treatment of infectious diseases and cancer. Although the intended targets of PS-binding mAbs have traditionally included pathogens as well as stressed tumor cells and its associated vasculature in oncology, the effects of PS-targeting mAbs on activated immune cells, notably T cells, which externalize PS upon Ag stimulation, is not well understood. Using human T cells from healthy donor PBMCs activated with an anti-CD3 + anti-CD28 Ab mixture (anti-CD3/CD28) as a model for TCR-mediated PS externalization and T cell stimulation, we investigated effects of two different PS-targeting mAbs, 11.31 and bavituximab (Bavi), on TCR activation and TCR-mediated cytokine production in an ex vivo paradigm. Although 11.31 and Bavi bind selectivity to anti-CD3/28 activated T cells in a PS-dependent manner, surprisingly, they display distinct functional activities in their effect on IFN-γ and TNF-ɑ production, whereby 11.31, but not Bavi, suppressed cytokine production. This inhibitory effect on anti-CD3/28 activated T cells was observed on both CD4+ and CD8+ cells and independently of monocytes, suggesting the effects of 11.31 were directly mediated by binding to externalized PS on activated T cells. Imaging showed 11.31 and Bavi bind at distinct focal depots on the cell membrane. Collectively, our findings indicate that PS-targeting mAb 11.31 suppresses cytokine production by anti-CD3/28 activated T cells.
Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21–Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells
Authors: van Asten Saskia D , Unger Peter-Paul , Marsman Casper , Bliss Sophie , Jorritsma Tineke , Thielens Nicole M , van Ham S Marieke , Spaapen Robbert M 
Published: July 2021

Abstract
Differentiation of Ag-specific B cells into class-switched, high-affinity, Ab-secreting cells provides protection against invading pathogens but is undesired when Abs target self-tissues in autoimmunity, beneficial non–self-blood transfusion products, or therapeutic proteins. Essential T cell factors have been uncovered that regulate T cell–dependent B cell differentiation. We performed a screen using a secreted protein library to identify novel factors that promote this process and may be used to combat undesired Ab formation. We tested the differentiating capacity of 756 secreted proteins on human naive or memory B cell differentiation in a setting with suboptimal T cell help in vitro (suboptimal CD40L and IL-21). High-throughput flow cytometry screening and validation revealed that type I IFNs and soluble FAS ligand (sFASL) induce plasmablast differentiation in memory B cells. Furthermore, sFASL induces robust secretion of IgG1 and IgG4 Abs, indicative of functional plasma cell differentiation. Our data suggest a mechanistic connection between elevated sFASL levels and the induction of autoreactive Abs, providing a potential therapeutic target in autoimmunity. Indeed, the modulators identified in this secretome screen are associated with systemic lupus erythematosus and may also be relevant in other autoimmune diseases and allergy.
T Cells Retain Pivotal Antitumoral Functions under Tumor-Treating Electric Fields
Authors: Diamant Gil , Simchony Goldman Hadar , Gasri Plotnitsky Lital , Roitman Marina , Shiloach Tamar , Globerson-Levin Anat , Eshhar Zelig , Haim Oz , Pencovich Niv , Grossman Rachel , Ram Zvi , Volovitz Ilan 
Published: July 2021

Abstract
Tumor-treating fields (TTFields) are a localized, antitumoral therapy using alternating electric fields, which impair cell proliferation. Combining TTFields with tumor immunotherapy constitutes a rational approach; however, it is currently unknown whether TTFields’ locoregional effects are compatible with T cell functionality. Healthy donor PBMCs and viably dissociated human glioblastoma samples were cultured under either standard or TTFields conditions. Select pivotal T cell functions were measured by multiparametric flow cytometry. Cytotoxicity was evaluated using a chimeric Ag receptor (CAR)–T–based assay. Glioblastoma patient samples were acquired before and after standard chemoradiation or standard chemoradiation + TTFields treatment and examined by immunohistochemistry and by RNA sequencing. TTFields reduced the viability of proliferating T cells, but had little or no effect on the viability of nonproliferating T cells. The functionality of T cells cultured under TTFields was retained: they exhibited similar IFN-γ secretion, cytotoxic degranulation, and PD1 upregulation as controls with similar polyfunctional patterns. Glioblastoma Ag–specific T cells exhibited unaltered viability and functionality under TTFields. CAR-T cells cultured under TTFields exhibited similar cytotoxicity as controls toward their CAR target. Transcriptomic analysis of patients’ glioblastoma samples revealed a significant shift in the TTFields-treated versus the standard-treated samples, from a protumoral to an antitumoral immune signature. Immunohistochemistry of samples before and after TTFields treatment showed no reduction in T cell infiltration. T cells were found to retain key antitumoral functions under TTFields settings. Our data provide a mechanistic insight and a rationale for ongoing and future clinical trials that combine TTFields with immunotherapy.
Evaluation of Screening Tests for Pre-Transplant Compatibility Testing in Live-Related Kidney Transplants
Authors: Chauhan Rajni , Tiwari Aseem Kumar , Rajvanshi Chhavi , Mehra Simmi , Aggarwal Geet , Bansal Shyam Bihari , Kher Vijay 
Published: July 2021

Introduction:
Pre-transplant compatibility testing involves the use of different methodologies (cell-based and solid phase based) for the determination of anti-human-leukocyte antigen (HLA) antibodies. Implementation of these donor-recipient methods in the screening of patients awaiting transplantation increased their chance of successful graft and patient outcomes.

Materials and Methods:
A total of 1054 patients visiting tertiary care hospitals for pretransplant compatibility testing were screened with cell-based tests; complement-dependent cytotoxicity crossmatch (CDC-XM) and flow cytometric crossmatch (FC-XM). The patients positive for either or both screening tests were suspected to have anti-HLA antibodies. Luminex single-antigen bead (SAB) tests were performed in such patients to determine and identify antibody specificity and establish donor-specific antibody (DSA).

Results:
The study showed a significantly higher sensitivity of the FCXM (94.6%) method when compared with CDC-XM (35.7%), considering the SAB assay as the gold standard technique. The specificity of CDC-XM (100%) was slightly higher than the FC-XM (76.3%). Combination of FC-XM with CDC-XM (17 cases) was 100% sensitive and specific to identify DSA (s). The graft-survival was 94.77% using the proposed algorithm.

Conclusions:
The combination of CDC-XM and FC-XM, along with SAB assay, could be used as a screening algorithm as it is a useful technique in identifying the specificities of alloantibodies, assessment of DSAs. Hence, the presented algorithm can become a new standard for the identification of potential recipients awaiting kidney transplantation in India.
Raoultella terrigena Infections in Hematopoietic Stem Cell Transplant Recipients
Authors: Mellouli Ameni , Chebbi Yosra , Raddaoui Anis , El Fatmi Rym , Ladeb Saloua , Othmen Tarek Ben , Achour Wafa 
Published: July 2021

Background:

Raoultella terrigena is a Gram-negative bacterium mainly reported as aquatic and soil organism. It is rarely involved in human infections. This study investigated the epidemiology of R. terrigena infections in the National Bone Marrow Transplant Center of Tunis (NBMTC) between January 2010 and March 2018, their associated antibiotics resistance patterns, and the molecular features of extended-spectrum β-lactamase (ESBL) producing strains.

Materials and Methods:
Our retrospective study concerned hematopoietic stem cell transplant (HSCT) adult recipients hospitalized at the NBMTC and infected with R. terrigena. The search of the ESBL and carbapenemases genes for multidrug-resistant strains was performed by PCR amplification.

Results:
Twelve strains of R. terrigena were responsible for infections in 10 hematopoietic stem cell transplant recipients (1.2% of total HSCT recipients). They were responsible for skin (n = 4) and urinary tract infections (n = 4). The first-line antibiotherapy was based on a monotherapy in one case and a dual therapy in eleven cases. Imipenem was the most prescribed antibiotic (n = 7/12). Mortality was attributable to R. terrigena infection in two over ten patients. Nine strains were producing ESBL. Five strains were resistant to ertapenem, two to imipenem, ten to ciprofloxacin, and five to amikacin. BlaCTX-M1
, blaOXA-48,
and bla
KPC were found in seven, four, and one strains, respectively.

Conclusion:
Low prevalence of R. terrigena infections in HSCT recipients but high rates of attributable mortality and multidrug-resistant strains.
Postexposure psychological sequelae in frontline health workers to COVID-19 in Andhra Pradesh, India
Authors: Das Keya , Ryali V. S. S. R. , Bhavyasree R. , Sekhar C. Madhu 
Published: July 2021

Introduction:
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 has engulfed the globe since December 2019. Healthcare workers remain at the forefront of this battle, and like prior pandemics face mental health challenges along with physical risks. We aimed to study the perceived stress and possible posttraumatic stress in the frontline workers exposed to active COVID-19 duties in the state of Andhra Pradesh, India.

Methodology:
A special voluntary, anonymous, survey-based Google questionnaire was designed with mandatory consent form and queries to clarify inclusion exclusion criteria. Tools included valid, reliable self-administered scales, namely General Health Questionnaire 12, Perceived Stress Scale and Impact of Events Scales-Revised. A purposive sampling method was adopted, by posting the survey questionnaire on WhatsApp groups of doctors, interns, and nurses working on active COVID-19 duty in Andhra Pradesh.

Results:
About 69.7% of the frontline workers recorded higher perceived stress and definitive posttraumatic stress disorder (PTSD) was found in 34.8%, with psychological distress recorded in 53%.

Conclusion:
The higher levels of perceived stress discovered in the vast majority with definitive PTSD features in a third of the sample indicates the need for provision of mental health support proactively among frontline workers on active COVID-19 duty.
Impact of mindfulness-based therapy on psychological characteristics of juveniles in conflict with law in India
Authors: Madiha Maria , Akhouri Deoshree 
Published: July 2021

Background:
According to National Crime Records Bureau, India, there has been a significant increase in criminal activities among juvenile over the past 3 years, especially in Uttar Pradesh in comparison to other Northern States. Various management strategies have been undertaken for such adolescents. However, there is a lack of management strategies in the Indian context for juvenile in conflict with law. Thus, this research work aims to see the effect of mindfulness-based therapy (MBT) on juveniles in conflict with law and not in conflict with law.

Aim:
The aim of the study was to see the effect of MBT on juveniles in conflict with law and not in conflict with law; to assess and compare the effect of MBT on their temperament, aggression, emotional quotient, and social quotient; and to see the effect of MBT on their level of mindfulness.

Methodology:
A total 25 adolescents of 13–19 years of age, both genders, literate and illiterate belonging from rural and urban population were included for the study. Among these, 17 juveniles in conflict with law were taken from District Child Protection Unit and eight juveniles not in conflict with law were taken from general adolescent population. After explaining the purpose of the study and attaining the consent from guardians, assessment was done using different psychological tools. MBT was used for the management. The pre-postresearch design was used.

Results and Conclusion:
Results obtained in this study are suggestive of that MBT is a fruitful management technique for juveniles in conflict with law serving in observation homes as well as for juveniles not in conflict with law.
Multiple cross-sectional assessments of empathy in medical undergraduate students
Authors: Shashikumar Ramadugu , Agarwal Kruti , Mohammad Aiman , Kaushik Chatterjee 
Published: July 2021

Introduction:
Empathy a cognitive phenomenon, with affective and behavioral components; helps improve clinical competence. It varies depending on physicians' gender and specialty. While some western studies reported significant fall in empathy levels when they progressed from non-clinical to clinical training years, Asian studies including Indian had varied results. We hypothesize that empathy will decrease among medical undergraduates over four years while they progress from non- clinical to clinical rotations and that female medical students and those opting for clinical specialties will have higher empathy than male medical students and those opting for non clinical specialty.

Methodology:
This study was carried out in a medical college from the year 2012 to 2015. Each year at the beginning of academic session all students were asked to complete Jefferson's -Scale for Physician's Empathy (JSPE student) student version. Over next three years similar assessments were repeated for all batches. The results were tabulated and analyzed using EpiInfo7 software.

Results:
Over four years 481, 416, 412 and 354 medical students in 1st, 2nd, 3rd and 4th year respectively from seven different batches were evaluated. Choice of specialty differed significantly in each year different batches. The empathy score had no relation to gender or choice of specialty. Empathy declines from first year onwards till third year but is not statistically significant.

Conclusion:
In this large multiple sample cross sectional study, it is evident empathy drops from 1st to 3rd year therefore there is an urgent need to evaluate why empathy falls.
Population-based seropositivity for IgG antibodies against SARS-CoV-2 in Ahmedabad city
Authors: Prakash Om , Solanki Bhavin , Sheth Jay , Oza Divyang , Kadam Mina , Vyas Sheetal , Shukla Aparajita , Pethani Jayshri , Tiwari Hemant 
Published: July 2021

Context:
Ahmedabad city with approximately 7 million population was one of the earliest cities to witness the high case load of COVID-19 pandemic in India. A population-based sero-survey was ideally suited in Ahmedabad to guide the public health response for managing COVID-19 pandemic.

Objectives:
To study the percentage sero-positivity for SARS-CoV-2 to understand the pandemic status and deriving conclusions for guiding the public health measures for managing the COVID-19 pandemic.

Settings and Design:
Population-based cross-sectional sero-surveillance.

Methods and Material:
Large scale sero-surveillance with population-based stratified sampling covering more than 10,000 samples from general population of Ahmedabad was carried out during second half of August 2020. The seropositivity was correlated and compared with various demographic factors and other parameters for valid and precise predictions on the immunity status of the population.

Results:
With 2,396 samples positive for IgG antibodies from a total of 10,310 samples, the seropositivity against COVID-19 in the general population of Ahmedabad is around 23.24%. The seropositivity has increasing trend with increasing age and is significantly higher among females (25.37%) than males (21.81%). The zone wise positivity ranged from 11.74% to 33.14%. This closely correlates with the cases recorded so far, higher for those zones with high current or past cases.

Conclusions:
Seropositivity of 23.24% in general population indicate the overall current level of protection. Since effective vaccine is not yet available, it is required to continue emphasis on the public health preventive measures for controlling and managing the COVID-19 pandemic.
Diagnostic accuracy of screening tools for chronic obstructive pulmonary disease in primary health care
Authors: Tyagi Jyoti , Moola Sandeep , Bhaumik Soumyadeep 
Published: July 2021

Background:
Chronic obstructive pulmonary disease (COPD) contributed significantly to burden of diseases in India, with missed, incorrect, and delayed diagnosis in primary care. We conducted a rapid evidence synthesis, to summarize the evidence on accuracy of the screening tests for COPD in primary health care on request form State Health Resource Centre, Chhattisgarh.

Methods:
Considering the rapid nature of decision making, our approach was to first search for existing systematic reviews. We identified one existing systematic review on the topic with the search conducted until 2014. We updated the review by searching in two major databases screened, title/abstracts, and full texts of studies as per eligibility criteria and extracted relevant data. A narrative synthesis was conducted.

Results:
We retrieved 7,007 and included five new studies, to add to 10 studies of the existing systematic review. Overall, 13 studies assessed diagnostic accuracy of screening questionnaires [e.g., COPD Diagnostic Questionnaire (CDQ)], five assessed handheld flow meters (COPD6 and PICO-6), and four assessed the combination of both the tests. The CDQ questionnaire using a score threshold ≥16.5 or >17 demonstrated comparatively a higher sensitivity both in pooled result for ever-smokers [87.5% (95% CI 83.1--90.9%)] and among the adults >35 years [73.8--93% (95% CI 69--98%)] when compared to a different score threshold of CDQ and other questionnaires. Handheld flow meters reported a pooled high sensitivity of 79.9% (95% CI 74.2--84.7%) in ever-smokers and 87.9% in adults with age >35 years.

Conclusions:
The need for better diagnosis of COPD in primary healthcare can be addressed by using of COPD Diagnostic Questionnaire alone or in combination with hand-held flow meters. There is scope for more implementation research on the domain.