bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation into deep hole drilling of austenitic steel with advanced tool solutions
Authors: Felinks Nils , Rinschede Timo , Biermann Dirk , Stangier Dominic , Tillmann Wolfgang , Fuß Moritz , Abrahams Hendrik 
Published: September 2021

AbstractDeep hole drilling processes for high-alloyed materials are characterised by worn guide pads and chatter vibrations. In order to increase feed rates, process stability and bore quality in STS deep hole drilling, various investigations were carried out with adjustments to the tool. First, a new process chain for the production of tribologically optimised guide pads and their effects on the guide pad shape is described in detail. The results of these studies show that the shape change in the area of the axial run-in chamfer through a micro finishing process leads to a better bore hole quality. Furthermore, the influence of guide pad coating and cooling lubricant on the deep hole drilling process was investigated. In addition, the machining of the austenitic steel AISI 304 is analysed by using a conventional steel boring bar and an innovative carbon fibre reinforced plastic (CFRP)-boring bar. While the conventional drill tube oscillates with different eigenfrequencies, the CFRP-boring bar damps chatter vibrations of the drill head and stabilises the process. Even at higher feed rates up tof= 0.3 mm, it is possible to machine austenitic, difficult-to-cut-materials with significantly reduced vibrations.
Territoriality is just an option: allocation of a resource fundamental to the resource defense polygyny in the European wool carder bee, Anthidium manicatum (Hymenoptera: Megachilidae)
Authors: Seidelmann Karsten 
Published: September 2021

Abstract
The wool carder bee Anthidium manicatum is one textbook example of resource defense polygyny among solitary bees, known for intense male–male competition, forced copulations, and the extreme form of interspecific territoriality toward other flower visitors. This mating system depends on the spatial structure of the defended resource and requires several adaptations in males. The allocation of patches with host plants as well as male body size and phenology was analyzed over 3 years in the diverse habitat of a botanical garden. Anthidium manicatum males searched in groups up to 12 individuals a wide diversity of patches with various food plants of foraging females. Territories were established in small high-quality patches only. Males abandoned aggressive and territorial behavior in large patches. Available patches were occupied by males of the various body size fractions independently of each other according to patch profitability. The higher competitive weight of large males in small patches compared to spacious ones was balanced by an opposing correlation of patch profitability. Although the mating system in A. manicatum is clearly a resource defense polygyny, males were found to be plastic in their behavior, and territoriality was not consistently observed. Mate acquiring tactics, be they territory holder (bourgeois), sneaker, floater, or scrambler for mating, can be considered to be different behavioral phenotypes within one environmentally sensitive conditional strategy.

Significance statement
Territoriality is a rare and derived pattern in solitary bee mating behavior. In most cases of territoriality, males defend rendezvous places to meet freshly emerged, virgin females. While this type of mating behavior fits still into the framework of ancestral monandry of aculeate Hymenoptera, the continually polyandric resource defense polygyny found in the genus Anthidium is highly derived. Males occupy flower resources exploited for larval provisions and extort copulations from provisioning nesting females. Territoriality in Anthidium does not lead to a monopolization of females, the exclusion of many competitors from reproduction, and a reduction of sperm competition as is typical for resource-based mating systems. Contrary, Anthidium is a highly promiscuous species and both males and females are lifelong engaged in copulations with multiple mates. Also, the allocation of the resource fundamental to the defense polygyny was found to be more fairly balanced than expected. This study diversifies the mating system of anthidiine bees and demonstrates unusually high plasticity in the resource allocation of a territorial species.
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
Authors: Lecour Sandrine , Andreadou Ioanna , Bøtker Hans Erik , Davidson Sean M. , Heusch Gerd , Ruiz-Meana Marisol , Schulz Rainer , Zuurbier Coert J. , Ferdinandy Péter , Hausenloy Derek J. ,   on behalf of the European Union-CARDIOPROTECTION COST ACTION CA16225, Adamovski Pavle , Andreadou Ioanna , Batirel Saime , Barteková Monika , Bertrand Luc , Beauloye Christophe , Biedermann David , Borutaite Vilmante , Bøtker Hans Erik , Chlopicki Stefan , Dambrova Maija , Davidson Sean , Devaux Yvan , Di Lisa Fabio , Djuric Dragan , Erlinge David , Falcao-Pires Ines , Ferdinandy Péter , Galatou Eleftheria , Garcia-Sosa Alfonso , Girao Henrique , Giricz Zoltan , Gyongyosi Mariann , Hausenloy Derek J , Healy Donagh , Heusch Gerd , Jakovljevic Vladimir , Jovanic Jelena , Kararigas George , Kerkal Risto , Kolar Frantisek , Kwak Brenda , Leszek Przemysław , Liepinsh Edgars , Lonborg Jacob , Longnus Sarah , Marinovic Jasna , Muntean Danina Mirela , Nezic Lana , Ovize Michel , Pagliaro Pasquale , Da Costa Gomes Clarissa Pedrosa , Pernow John , Persidis Andreas , Pischke Søren Erik , Podesser Bruno , Potočnjak Ines , Prunier Fabrice , Ravingerova Tanya , Ruiz-Meana Marisol , Serban Alina , Slagsvold Katrine , Schulz Rainer , van Royen Niels , Turan Belma , Vendelin Marko , Walsh Stewart , Zidar Nace , Zuurbier Coert , Yellon Derek 
Published: September 2021

AbstractAcute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against acute ischemia/reperfusion injury to reduce myocardial infarct size and prevent the onset of HF in patients presenting with AMI. However, the clinical translation of cardioprotective interventions that have proven to be beneficial in preclinical animal studies, has been challenging. One likely major reason for this failure to translate cardioprotection into patient benefit is the lack of rigorous and systematic in vivo preclinical assessment of the efficacy of promising cardioprotective interventions prior to their clinical evaluation. To address this, we propose an in vivo set of step-by-step criteria for IMproving Preclinical Assessment of Cardioprotective Therapies (‘IMPACT’), for investigators to consider adopting before embarking on clinical studies, the aim of which is to improve the likelihood of translating novel cardioprotective interventions into the clinical setting for patient benefit.
Towards a universal shear correction factor in filament stretching rheometry
Authors: van Berlo F. P. A. , Cardinaels R. , Peters G. W. M. , Anderson P. D. 
Published: September 2021

AbstractFilament stretching rheometry is a prominent experimental method to determine rheological properties in extensional flow whereby the separating plates determine the extension rate. In literature, several correction factors that can compensate for the errors introduced by the shear contribution near the plates have been introduced and validated in the linear viscoelastic regime. In this work, a systematic analysis is conducted to determine if a material-independent correction factor can be found for non-linear viscoelastic polymers. To this end, a finite element model is presented to describe the flow and resulting stresses in the filament stretching rheometer. The model incorporates non-linear viscoelasticity and a radius-based controller for the plate speed is added to mimic the typical extensional flow in filament stretching rheometry. The model is validated by comparing force simulations with analytical solutions. The effects of the end-plates on the extensional flow and resulting force measurements are investigated, and a modification of the shear correction factor is proposed for the non-linear viscoelastic flow regime. This shows good agreement with simulations performed at multiple initial aspect ratios and strain rates and is shown to be valid for a range of polymers with non-linear rheological behaviour.
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders
Authors: Kurzawa-Akanbi Marzena , Tammireddy Seshu , Fabrik Ivo , Gliaudelytė Lina , Doherty Mary K. , Heap Rachel , Matečko-Burmann Irena , Burmann Björn M. , Trost Matthias , Lucocq John M. , Gherman Anda V. , Fairfoul Graham , Singh Preeti , Burté Florence , Green Alison , McKeith Ian G. , Härtlova Anetta , Whitfield Phillip D. , Morris Christopher M. 
Published: September 2021

AbstractMutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD)—collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutations increase susceptibility to develop LBD. We investigated relationships between LBD-specific glucocerebrosidase deficits, GBA-related pathways, and α-synuclein levels in brain tissue from LBD and controls, with and without GBA mutations. We show that LBD is characterised by altered sphingolipid metabolism with prominent elevation of ceramide species, regardless of GBA mutations. Since extracellular vesicles (EV) could be involved in LBD pathogenesis by spreading disease-linked lipids and proteins, we investigated EV derived from post-mortem cerebrospinal fluid (CSF) and brain tissue from GBA mutation carriers and non-carriers. EV purified from LBD CSF and frontal cortex were heavily loaded with ceramides and neurodegeneration-linked proteins including alpha-synuclein and tau. Our in vitro studies demonstrate that LBD EV constitute a “pathological package” capable of inducing aggregation of wild-type alpha-synuclein, mediated through a combination of alpha-synuclein–ceramide interaction and the presence of pathological forms of alpha-synuclein. Together, our findings indicate that abnormalities in ceramide metabolism are a feature of LBD, constituting a promising source of biomarkers, and that GBA mutations likely accelerate the pathological process occurring in sporadic LBD through endolysosomal deficiency.
Eduard Gamper (1887–1938): cases and accidents
Authors: Ruzicka Evzen , Hinterhuber Hartmann , Förstl Hans 
Published: September 2021

AbstractEduard Gamper (1887–1938) was Head of the Department of Neuropsychiatry at the Charles University’s German Faculty of Medicine in Prague. He had trained in Innsbruck, where he undertook groundbreaking work on the midbrain in an anencephalic child and in a series of patients who had died from Wernicke’s encephalopathy. Gamper identified the mamillary bodies as key in the performance of declarative memory. Considered an expert in memory disorders, he was chosen by the Medical Faculty in Innsbruck to provide expert opinion on the notorious case of Philipp Halsmann, who was suspected of murdering his father. Details of the case remained unresolved and Gamper’s opinion caused both professional and political controversy. When in Prague, Gamper made great efforts to improve patient care and clinical services, establishing a special ward for patients with neurological conditions. This task was not nearly completed, when he and his wife died after their car drove over a cliff into the Walchensee in Bavaria. Rumours surrounded his death: that Gamper had just examined Adolf Hitler; that he was a political victim; that the Gestapo were behind the accident. After an investigation of the available evidence, we can report that an unusual 22 cm of snow fell in the area of the Walchensee on April 20, 1938, the day of the Gampers’ deaths. We were unable to find any evidence for foul play in what appears to have been a tragic accident.
Diagnostik und Therapie bei Haarausfall und Hirsutismus
Authors: Kopera Daisy 
Published: September 2021

ZusammenfassungKaum ein Symptom kann so irritierend sein wie die unwillentliche Veränderung des Behaarungsmusters. Haarverlust an sich ist ein Phänomen, das durch die asynchron verlaufenden Wachstumsphasen der einzelnen Haarfollikel physiologisch zum Verlust von etwa 100 Kopfhaaren pro Tag führt. Die Ursachen für einen darüber hinausgehenden Haarausfall sind vielfältig: Sie können hormonell, psychosomatisch oder autoimmunologisch sein, aber auch alimentär oder paraneoplastisch. In diesem Beitrag werden die unterschiedlichen Formen von Haarausfall (Alopezien) erläutert, ergänzend wird auch das unerwünscht vermehrte Haarwachstum bei Frauen (Hirsutismus) erklärt. Die Behandlung der jeweiligen Alopezie ist aufgrund der unterschiedlichen Ursachen nicht in einen allgemeingültigen Algorithmus zu fassen.
The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof
Authors: Veldhuizen Gregory P. , Alnazer Rawan M. , de Leeuw Peter W. , Kroon Abraham A. 
Published: September 2021

Abstract
Purpose
Hydralazine, doxazosin, and verapamil are currently recommended by the Endocrine Society as acceptable bridging treatment in those in whom full cessation of antihypertensive medication is infeasible during screening for primary aldosteronism (PA). This is under the assumption that they cause minimal to no effect on the aldosterone-to-renin ratio, the most widely used screening test for PA. However, limited evidence is available regarding the effects of these particular drugs on said ratio.

Methods
In the present study, we retrospectively assessed the changes in aldosterone, renin, and aldosterone-to-renin values in essential hypertensive participants before and after treatment with either hydralazine (n = 26) or doxazosin (n = 20) or verapamil (n = 15). All samples were taken under highly standardized conditions.

Results
Hydralazine resulted in a borderline significant rise in active plasma renin concentration (19 vs 25 mIU/L, p = 0.067) and a significant fall in the aldosterone-to-renin ratio (38 vs 24, p = 0.017). Doxazosin caused declines in both plasma aldosterone concentration (470 vs 330 pmol/L, p = 0.028) and the aldosterone-to-renin ratio (30 vs 20, p = 0.020). With respect to verapamil, we found no statistically significant effect on any of these outcome variables.

Conclusion
We conclude that the assumption that these drugs can be used with little consequence to the aldosterone-to-renin cannot be substantiated. While it is possible that they are indeed the best option when full antihypertensive drug cessation is infeasible, the potential effects of these drugs must still be taken into account when interpreting the aldosterone-to-renin ratio.
Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study
Authors: Bhatta Laxmi , Cepelis Aivaras , Vikjord Sigrid A. , Malmo Vegard , Laugsand Lars E. , Dalen Håvard , Langhammer Arnulf , Janszky Imre , Strand Linn B. , Brumpton Ben M. 
Published: September 2021

AbstractThe association between bone mineral density (BMD) and cardiovascular disease (CVD) is not fully understood. We evaluated BMD as a risk factor for cardiovascular disease and specifically atrial fibrillation (AF), acute myocardial infarction (AMI), ischemic (IS) and hemorrhagic stroke (HS) and heart failure (HF) in men and women. This prospective population cohort utilized data on 22 857 adults from the second and third surveys of the HUNT Study in Norway free from CVD at baseline. BMD was measured using single and dual-energy X-ray absorptiometry in the non-dominant distal forearm and T-score was calculated. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated from adjusted cox proportional hazards models. The analyses were sex-stratified, and models were adjusted for age, age-squared, BMI, physical activity, smoking status, alcohol use, and education level. Additionally, in women, we adjusted for estrogen use and postmenopause. During a mean follow-up of 13.6 ± 5.7 years, 2 928 individuals (12.8%) developed fatal or non-fatal CVD, 1 020 AF (4.5%), 1 172 AMI (5.1%), 1 389 IS (6.1%), 264 HS (1.1%), and 464 HF (2.0%). For every 1 unit decrease in BMD T-score the HR for any CVD was 1.01 (95% CI 0.98 to 1.04) in women and 0.99 (95% CI 0.94 to 1.03) in men. Point estimates for the four cardiovascular outcomes ranged from slightly protective (HR 0.95 for AF in men) to slightly deleterious (HR 1.12 for HS in men). We found no evidence of association of lower distal forearm BMD with CVD, AF, AMI, IS, HS, and HF.
Origins space telescope: from first light to life
Authors: Wiedner M. C. , Aalto S. , Armus L. , Bergin E. , Birkby J. , Bradford C. M. , Burgarella D. , Caselli P. , Charmandaris V. , Cooray A. , De Beck E. , Desert J. M. , Gerin M. , Goicoechea J. , Griffin M. , Hartogh P. , Helmich F. , Hogerheijde M. , Hunt L. , Karska A. , Kral Q. , Leisawitz D. , Melnick G. , Meixner M. , Matsuura M. , Milam S. , Pearson C. , Pesce D. W. , Pontoppidan K. M. , Pope A. , Rigopoulou D. , Roellig T. , Sakon I. , Staguhn J. , Stevenson K. 
Published: September 2021

AbstractThe Origins Space Telescope (Origins) is one of four science and technology definition studies selected by the National Aeronautics and Space Administration (NASA) in preparation of the 2020 Astronomy and Astrophysics Decadal survey in the US. Origins will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. It is designed to answer three major science questions: How do galaxies form stars, make metals, and grow their central supermassive black holes from reionization? How do the conditions for habitability develop during the process of planet formation? Do planets orbiting M-dwarf stars support life? Origins operates at mid- to far-infrared wavelengths from ~ 2.8 μm to 588 μm, and is more than 1000 times more sensitive than prior far-IR missions due to its cold (~ 4.5 K) aperture and state-of-the-art instruments.
A Parallel Dynamic Asynchronous Framework for Uncertainty Quantification by Hierarchical Monte Carlo Algorithms
Authors: Tosi Riccardo , Amela Ramon , Badia Rosa M. , Rossi Riccardo 
Published: September 2021

AbstractThe necessity of dealing with uncertainties is growing in many different fields of science and engineering. Due to the constant development of computational capabilities, current solvers must satisfy both statistical accuracy and computational efficiency. The aim of this work is to introduce an asynchronous framework for Monte Carlo and Multilevel Monte Carlo methods to achieve such a result. The proposed approach presents the same reliability of state of the art techniques, and aims at improving the computational efficiency by adding a new level of parallelism with respect to existing algorithms: between batches, where each batch owns its hierarchy and is independent from the others. Two different numerical problems are considered and solved in a supercomputer to show the behavior of the proposed approach.
Religion-Adapted Cognitive Behavioral Therapy: A Review and Description of Techniques
Authors: de Abreu Costa Marianna , Moreira-Almeida Alexander 
Published: September 2021

AbstractSystematic reviews have shown the efficacy of religion-adapted cognitive behavioral therapy (R-CBT); however, many clinicians lack practical knowledge of these protocols. We describe here the techniques of religious adaptation to CBT that have proved effective. We selected randomized clinical trials comparing R-CBT with control conditions in clients with a diagnosis of a psychiatric disorder and extracted the information from their adapted manuals. The most frequent religious adaptations were the integration of religious content to perform cognitive restructuring, psychoeducation and motivation; engagement in religious activities such as behavioral activation, meditation, or prayer to help cognitive restructuring, using religious values and coping strategies. A description of these techniques is presented here, as well as some practical examples.
Local search approaches for the test laboratory scheduling problem with variable task grouping
Authors: Mischek Florian , Musliu Nysret , Schaerf Andrea 
Published: September 2021

AbstractThe Test Laboratory Scheduling Problem (TLSP) is a real-world scheduling problem that extends the well-known Resource-Constrained Project Scheduling Problem (RCPSP) by several new constraints. Most importantly, the jobs have to be assembled out of several smaller tasks by the solver, before they can be scheduled. In this paper, we introduce different metaheuristic solution approaches for this problem. We propose four new neighborhoods that modify the grouping of tasks. In combination with neighborhoods for scheduling, they are used by our metaheuristics to produce high-quality solutions for both randomly generated and real-world instances. In particular, Simulated Annealing managed to find solutions that are competitive with the best known results and improve upon the state-of-the-art for larger instances. The algorithm is currently used for the daily planning of a large real-world laboratory.
The role of the dentist and orthodontist in recognizing oro-facial manifestations of acromegaly: a questionnaire-based study
Authors: Preo Giorgia , De Stefani Alberto , Dassie Francesca , Wennberg Alexandra , Vettor Roberto , Maffei Pietro , Gracco Antonio , Bruno Giovanni 
Published: September 2021

Abstract
Purpose
Oro-facial manifestations of acromegaly are among the earliest signs of the disease and are reported by a significant number of patients at diagnosis. Despite this high prevalence of acromegaly oral manifestation, dentists do not play a pivotal role in acromegaly identification and diagnosis. The aim of our study was to evaluate the ability of dentists and orthodontists in the early recognition of the oro-facial manifestations of acromegaly.

Methods
A telematic questionnaire was administered to dentists and orthodontists. The questionnaire included photos with facial and oral-dental details and lateral teleradiography of acromegaly patients (ACRO).

Results
The study included 426 participants: 220 dentists and 206 orthodontists. Upon reviewing the photos, dentists most often observed mandibular prognathism and lips projection, while orthodontists also reported the impairment of relative soft tissue. Orthodontists, who usually use photos to document patients’ oral-facial characteristics, paid more attention to oral-facial impairment than dentists. During dental assessment, 90% of the participants usually evaluated tongue size and appearance, diastemas presence, and signs of sleep impairment (mainly orthodontists). Orthodontists were also more able to identify sella turcica enlargement at teleradiography. A total of 10.8% of the participants had ACRO as patients and 11.3% referred at least one patient for acromegaly suspicion.

Conclusion
The study highlighted dentists’ strategic role in identifying ACRO. Increasing dentists’ awareness about acromegaly clinical issues may improve early diagnosis, potentially resulting in an increased quality of life and decreased mortality among ACRO.