bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low density lipoprotein cholesterol and all-cause mortality rate: findings from a study on Japanese community-dwelling persons
Authors: Kawamoto Ryuichi , Kikuchi Asuka , Akase Taichi , Ninomiya Daisuke , Kumagi Teru 
Published: September 2021

AbstractBackgroundLow-density lipoprotein cholesterol (LDL-C) independently impacts aging-related health outcomes and plays a critical role in cardiovascular diseases (CVDs). However, there are limited predictive data on all-cause mortality, especially for the Japanese community population. In this study, it was examined whether LDL-C is related to survival prognosis based on 7 or 10 years of follow-up.MethodsParticipants included 1610 men (63 ± 14 years old) and 2074 women (65 ± 12 years old) who participated in the Nomura cohort study conducted in 2002 (first cohort) and 2014 (second cohort) and who continued throughout the follow-up periods (follow-up rates: 94.8 and 98.0%). Adjusted relative risk estimates were obtained for all-cause mortality using a basic resident register. The data were analyzed by a Cox regression with the time variable defined as the length between the age at the time of recruitment and that at the end of the study (the age of death or censoring), and risk factors including gender, age, body mass index (BMI), presence of diabetes, lipid levels, renal function, serum uric acid levels, blood pressure, and history of smoking, drinking, and CVD.ResultsOf the 3684 participants, 326 (8.8%) were confirmed to be deceased. Of these, 180 were men (11.2% of all men) and 146 were women (7.0% of all women). Lower LDL-C levels, gender (male), older age, BMI under 18.5 kg/m2, and the presence of diabetes were significant predictors for all-cause mortality. Compared with individuals with LDL-C levels of 144 mg/dL or higher, the multivariable-adjusted Hazard ratio (and 95% confidence interval) for all-cause mortality was 2.54 (1.58–4.07) for those with LDL-C levels below 70 mg/dL, 1.71 (1.15–2.54) for those with LDL-C levels between 70 mg/dL and 92 mg/dL, and 1.21 (0.87–1.68) for those with LDL-C levels between 93 mg/dL and 143 mg/dL. This association was particularly significant among participants who were male (Pfor interaction = 0.039) and had CKD (Pfor interaction = 0.015).ConclusionsThere is an inverse relationship between LDL-C levels and the risk of all-cause mortality, and this association is statistically significant.
Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability
Authors: Barnes Sarah E. , Zera Kristy A. , Ivison Geoffrey T. , Buckwalter Marion S. , Engleman Edgar G. 
Published: September 2021

AbstractBackgroundPatients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and dementia. However, the mechanistic basis for these associations is unknown. Given that many patients are unresponsive to existing medications or experience debilitating side effects, novel therapeutics that target the underlying pathophysiology of these conditions are urgently needed.MethodsBecause intestinal disorders such as inflammatory bowel disease are robustly associated with neurological symptoms, we used three different mouse models of colitis to investigate the impact of peripheral inflammatory disease on the brain. We assessed neuronal hyperexcitability, which is associated with many neurological symptoms, by measuring seizure threshold in healthy and colitic mice. We profiled the neuroinflammatory phenotype of colitic mice and used depletion and neutralization assays to identify the specific mediators responsible for colitis-induced neuronal hyperexcitability. To determine whether our findings in murine models overlapped with a human phenotype, we performed gene expression profiling, pathway analysis, and deconvolution on microarray data from hyperexcitable human brain tissue from patients with epilepsy.ResultsWe observed that murine colitis induces neuroinflammation characterized by increased pro-inflammatory cytokine production, decreased tight junction protein expression, and infiltration of monocytes and neutrophils into the brain. We also observed sustained neuronal hyperexcitability in colitic mice. Colitis-induced neuronal hyperexcitability was ameliorated by neutrophil depletion or TNFα blockade. Gene expression profiling of hyperexcitable brain tissue resected from patients with epilepsy also revealed a remarkably similar pathology to that seen in the brains of colitic mice, including neutrophil infiltration and high TNFα expression.ConclusionsOur results reveal neutrophils and TNFα as central regulators of neuronal hyperexcitability of diverse etiology. Thus, there is a strong rationale for evaluating anti-inflammatory agents, including clinically approved TNFα inhibitors, for the treatment of neurological and psychiatric symptoms present in, and potentially independent of, a diagnosed inflammatory disorder.
Impact of an educational programme on Alzheimer’s disease patients’ quality of life: results of the randomized controlled trial THERAD
Authors: Villars Hélène , Cantet Christelle , de Peretti Eva , Perrin Amelie , Soto-martin Maria , Gardette Virginie 
Published: September 2021

Abstract
Background
Although educational interventions are recommended in Alzheimer’s disease (AD), studies assessing the impact of interventions such as “therapeutic patient education” are scarce. Indeed, the intrinsic nature of the disease is considered a barrier to patients’ involvement in such approaches. We aimed to evaluate an intervention by using a “dyadic” approach (patient and caregiver) in both intervention and assessment.

Methods
THERAD is a monocentric, randomized, controlled trial assessing the effects of a 2-month educational programme in mild to moderately severe AD patients among 98 dyads (caregiver/patient) on caregiver-reported patient quality of life (QOL) at 2 months. Community-dwelling patients and their caregivers were recruited in ambulatory units of the French Toulouse University Hospital. Self-reported patient QOL, autonomy, behavioural and psychological symptoms and caregiver QOL and burden were collected at 2, 6 and 12 months. Linear mixed models were used in modified intention-to-treat populations. We also performed sensitivity analysis.

Results
A total of 196 dyads were included, 98 in each group. The mean age of the patients was 82 years, 67.7% were women, diagnosed with AD (+/- cerebrovascular component) (mean MMSE =17.6), and 56.9% lived with a partner. The mean age of the caregivers was 65.7 years, and 64.6% were women (52.3% offspring/42.6% spouses), with a moderate burden (mean Zarit score = 30.9). The mean caregiver-reported patient QOL was lower than the self-reported QOL (28.61 vs. 33.96). We did not identify any significant difference in caregiver-reported patients’ QOL (p = 0.297) at 2 months, but there was a significant difference in self-reported patients’ QOL at 2 months (p = 0.0483) or 6 months (p = 0.0154). No significant difference was found for the secondary outcomes. The results were stable in the sensitivity analyses.

Conclusions
This randomized controlled trial assessing an educational intervention in 196 dyads (Alzheimer’s disease affected patient/caregiver) highlights the need to better consider the patient’s point of view, since only the self-reported QOL was improved. Additional studies using this dyadic approach are necessary in targeted subpopulations of caregivers (spouse vs. child, gender) and of patients (severity of cognitive impairment or behavioural disturbances)

Trial registration
THERAD study NCT01796314. Registered on February 19, 2013.
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only
Authors: Grimbert Lucile , Sanz Maria-Nieves , Gressette Mélanie , Rucker-Martin Catherine , Novotova Marta , Solgadi Audrey , Karoui Ahmed , Gomez Susana , Bedouet Kaveen , Jacquet Eric , Lemaire Christophe , Veksler Vladimir , Mericskay Mathias , Ventura-Clapier Renée , Piquereau Jérôme , Garnier Anne 
Published: September 2021

Abstract
Background
The AMP-activated protein kinase (AMPK) is a major regulator of cellular energetics which plays key role in acute metabolic response and in long-term adaptation to stress. Recent works have also suggested non-metabolic effects.

Methods
To decipher AMPK roles in the heart, we generated a cardio-specific inducible model of gene deletion of the main cardiac catalytic subunit of AMPK (Ampkα2) in mice. This allowed us to avoid the eventual impact of AMPK-KO in peripheral organs.

Results
Cardio-specific Ampkα2 deficiency led to a progressive left ventricular systolic dysfunction and the development of cardiac fibrosis in males. We observed a reduction in complex I-driven respiration without change in mitochondrial mass or in vitro complex I activity, associated with a rearrangement of the cardiolipins and reduced integration of complex I into the electron transport chain supercomplexes. Strikingly, none of these defects were present in females. Interestingly, suppression of estradiol signaling by ovariectomy partially mimicked the male sensitivity to AMPK loss, notably the cardiac fibrosis and the rearrangement of cardiolipins, but not the cardiac function that remained protected.

Conclusion
Our results confirm the close link between AMPK and cardiac mitochondrial function, but also highlight links with cardiac fibrosis. Importantly, we show that AMPK is differently involved in these processes in males and females, which may have clinical implications for the use of AMPK activators in the treatment of heart failure.
Enhanced recovery after surgery for hip fractures: a systematic review and meta-analysis
Authors: Liu Song-yang , Li Ci , Zhang Pei-xun 
Published: September 2021

Abstract
Background
Enhanced recovery after surgery (ERAS) programs have achieved promising results in many surgical specialties. However, uncertainty still remains regarding the effect of ERAS on hip fractures. The objective of this review was to investigate the clinical prognosis of ERAS programs in terms of (1) hospital-related endpoints (time to surgery [TTS], length of stay [LOS]), (2) readmission rate, (3) complications, and (4) mortality.

Methods
Published literature was searched in the PubMed, EMBASE, and Cochrane Library databases. All of the included studies met the inclusion criteria. The primary outcomes were TTS and LOS. The secondary outcomes included the 30-day readmission rate, overall complication rate, specific complication rate (delirium and urinary tract infection), and 30-day and 1-year mortality. Language was restricted to English. The data analysis was carried out by Review Manager 5.3.

Results
A total of 7 published studies (9869 patients) were finally included, and these were all cohort studies. The meta-analysis showed that the TTS, LOS, and overall complication rate were significantly reduced in the ERAS group compared with the control group (p < 0.01). Moreover, no significant change was found in the 30-day readmission rate or 30-day and 1-year mortality.

Conclusions
ERAS significantly decreases the TTS, LOS, and complication rate without increasing readmission rate and mortality, which adds to the evidence that the implementation of ERAS is beneficial to patients undergoing hip fracture repair surgeries.
Artificial lightning strike tests and coupled electrical–thermal analysis on roofing glazed tiles of ancient buildings
Authors: Li Jingxiao , Fang Zhiling , Fu Lin , Fu Shangchen , Shi Lihua , Li Yun , Huo Peidong 
Published: September 2021

Abstract
Lightning strike is one of the natural disasters to the roof components of ancient buildings. To investigate the causes and damage effects of lightning strikes on the roofing glazed tiles of ancient buildings, artificial lightning strike tests were carried out on glazed tiles. Based on the experiment results, a coupled electrical–thermal finite element model of mortar-containing glazed tiles was established and the Joule heat effect of lightning current was further investigated. The results show that when the lightning channel is attached to the surface of the enamel and body with a low electrical conductivity, the lightning current is mainly released in the form of surface flashover, and a minor damage is induced along the flashover path; when the lightning channel is attached to the mortar with a high electrical conductivity, the lightning current is injected into the mortar, resulting in significant tile damage. The spatial distributions of the temperature present clear gradient characteristics. The high-temperature area appears in the mortar while the high–thermal–stress area appears in the body connected to the grounding rail. As the peak of the lightning current increases, both the high-temperature and high–thermal–stress areas of the glazed tiles expand. The combination of the experiments and the numerical analysis results demonstrate that the damage mechanism of lightning Joule heat effect to glazed tiles may include two aspects. One is the internal explosive force generated from the sharp vaporization and expansion of the moisture inside the tiles due to rapid temperature increase, and the other is the thermal stress caused by the uneven temperature distribution.
Monitoring of Paraquat in soya products intended for animal feed
Authors: Heydebreck Franziska 
Published: September 2021

AbstractEven though paraquat is considered to be one of the most toxic herbicides, it is one of the most used ones. Paraquat-based preparations are heavily used across many important agricultural countries and for a lot of types of crops such as soya. As soya is used in large quantities in the feed production, paraquat residues in soya products are a potential threat to livestock. The aim of this study was to investigate whether soya products intended for animal feed contain residues of paraquat. Therefore, an optimized Quick Polar Pesticides (QuPPe) Method was developed. In total, 174 samples were analyzed via LC-MS/MS using zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC). The results showed that paraquat was detected in 66 % of the samples above 0.008 mg/kg. Residues were mainly present in soya bean meals that were imported from Brazil or the USA and cultivated using genetically modified soya. Around 5 % of the samples were not compliant with the European regulation on maximum residue levels of pesticides in or on food and feed. The results of this study support the view that paraquat residues play a significant role in soya products intended for animal feed and, thus, need to be controlled on a regular basis. However, for enforcement actions reliable processing factors for paraquat in soya products or maximum residue levels for processed soya products are urgently required.
Near real time flood inundation mapping using social media data as an information source: a case study of 2015 Chennai flood
Authors: Karmegam Dhivya , Ramamoorthy Sivakumar , Mappillairaju Bagavandas 
Published: September 2021

AbstractDuring and just after flash flood, data regarding water extent and inundation will not be available as the traditional data collection methods fail during disasters. Rapid water extent map is vital for disaster responders to identify the areas of immediate need. Real time data available in social networking sites like Twitter and Facebook is a valuable source of information for response and recovery, if handled in an efficient way. This study proposes a method for mining social media content for generating water inundation mapping at the time of flood. The case of 2015 Chennai flood was considered as the disaster event and 95 water height points with geographical coordinates were derived from social media content posted during the flood. 72 points were within Chennai and based on these points water extent map was generated for the Chennai city by interpolation. The water depth map generated from social media information was validated using the field data. The root mean square error between the actual water height data and extracted social media data was ± 0.3 m. The challenge in using social media data is to filter the messages that have water depth related information from the ample amount of messages posted in social media during disasters. Keyword based query was developed and framed in MySQL to filter messages that have location and water height mentions. The query was validated with tweets collected during the floods that hit Mumbai city in July 2019. The validation results confirm that the query reduces the volume of tweets for manual evaluation and in future will aid in mapping the water extent in near real time at the time of floods.
Endoscopic management of periventricular and intraventricular arachnoid cysts
Authors: Fayed Ahmed Abdel Aziz , Ibrahim Tamer , Rayan Tarek 
Published: September 2021

Abstract
Introduction
The most successful surgical management of periventricular and intraventricular cysts is still a matter of debate. Up to the early 1990s, open cyst fenestration and cystoperitoneal shunts were the only options available. Recently, different endoscopic approaches to these lesions have gained popularity.

Methods
Eighteen endoscopic procedures were performed for the treatment of arachnoid cysts in 18 patients. Sylvian fissure arachnoid cysts were excluded from this study. Ten of them were females and eight were males with their ages ranging from 6 months to 50 years with a mean of 16 years. All patients were prospectively observed.

Results
Seven of the arachnoid cysts were in the suprasellar region, 5 in the quadrigeminal region, 2 in the posterior fossa, 2 parietal, and 2 intraventricular. Seventeen cases (94%) had hydrocephalus. The main presenting manifestations were those of increased intracranial pressure. All fenestrations were done in the lateral ventricle except for the 2 cases with posterior fossa arachnoid cysts, the fenestrations were done to the fourth ventricle. Endoscopic ventriculocytostomies (VC) were performed in 14 cases without operative complications and no stents were placed. Endoscopic cystocisternostomies (C) were done in all suprasellar cases. Endoscopic cystoventriculostomies (CV) were done in 4 cases. The mean surgical time was 1 h. The mean follow-up period was 15 months. Symptoms improved in 17 cases. Seventeen cases demonstrated a significant decrease of the cysts’ size in the postoperative computed tomography (CT) and magnetic resonance imaging (MRI). A single case developed a complication in the form of subdural hygroma which required no intervention and was managed conservatively.

Conclusion
Endoscopic management of periventricular and intraventricular arachnoid cysts is a useful safe option in the management of arachnoid cysts related to the ventricular system.
Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis
Authors: Mac Grory Brian , Nossek Erez , Reznik Michael E. , Schrag Matthew , Jayaraman Mahesh , McTaggart Ryan , de Havenon Adam , Yaghi Shadi , Feng Wuwei , Furie Karen , Boyanpally Anusha 
Published: September 2021

Introduction
The carotid web is a compelling potential mechanism of embolic ischemic stroke. In this study, we aim to determine the prevalence of ipsilateral carotid web in a cohort of ischemic stroke patients and to perform a systematic review and meta-analysis of similar cohorts.

Patients & methods
We performed a retrospective, observational, cohort study of acute ischemic stroke patients admitted to a comprehensive stroke center from June 2012 to September 2017. Carotid web was defined on computed tomography angiography (CTA) as a thin shelf of non-calcified tissue immediately distal to the carotid bifurcation. We described the prevalence of carotid artery webs in our cohort, then performed a systematic review and meta-analysis of similar cohorts in the published literature.

Results
We identified 1,435 potentially eligible patients of whom 879 met criteria for inclusion in our analysis. An ipsilateral carotid web was detected in 4 out of 879 (0.45%) patients, of which 4/4 (1.6%) were in 244 patients with cryptogenic stroke and 3/4 were in 66 (4.5%) patients <60 years old with cryptogenic stroke. Our systematic review yielded 3,192 patients. On meta-analysis, the pooled prevalence of ipsilateral carotid web in cryptogenic stroke patients <60 was 13% (95% CI: 7%-22%; I2 = 66.1%). The relative risk (RR) of ipsilateral versus contralateral carotid web in all patients was 2.5 (95% CI 1.5–4.2, p = 0.0009) whereas in patients less than 60 with cryptogenic stroke it was 3.0 (95% CI 1.6–5.8, p = 0.0011).

Discussion
Carotid webs are more common in young patients with cryptogenic stroke than in other stroke subtypes. Future studies concerning the diagnosis and secondary prevention of stroke associated with carotid web should focus on this population.
Education, Arts and Sustainability: Emerging Practice for a Changing World, Mary Ann Hunter, Arnold Aprill, Allen Hill and Sherridan Emery (eds) (2018)
Authors: Babu Kudrat-E-Khuda 
Published: September 2021

Review of: Education, Arts and Sustainability: Emerging Practice for a Changing World, Mary Ann Hunter, Arnold Aprill, Allen Hill and Sherridan Emery (eds) (2018)
Singapore: Springer, 120 pp.,
ISBN 978-9-81107-709-6, p/bk, $24.99
Mind your Prayers. Aristotle’s Notion ofeuchê
Authors: Kontos Pavlos 
Published: September 2021

AbstractIn Aristotle’s world there is no God to answer our prayers (euchê) and yet prayers follow the excellent city of thePoliticslike a shadow. Nonetheless, as far as I know, people have been content to narrow the focus of investigation to Aristotle’s utopia, its plausibility, structure and infrastructure, leaving prayers out of the picture. The most prayers themselves seem to deserve is a footnote or so. The result is that attention is switched away from the most basic questions: What is the function of practical reason that prayers are meant to perform and why could not, or should not, that function be carried out by deliberate choices, wishes, and action plans? Prayers matter, and matter a lot, so I will argue, for they mirror our understanding ofconstitutivemoral luck. The legislators and the rulers who ignore or overlook this truth are theoretically incompetent and politically perilous.
Expert Impressions in Stoicism
Authors: Veres Máté , Machek David 
Published: September 2021

Abstract
We focus on the question of how expertise as conceived by the Stoics interacts with the content of impressions. In Section 1, we situate the evidence concerning expert perception within the Stoic account of cognitive development. In Section 2, we argue that the content of rational impressions, and notably of expert impressions, is not exhausted by the relevant propositions. In Section 3, we argue that expert impressions are a subtype of kataleptic impressions which achieve their level of clarity and distinctness due to the contribution of expertise. In Section 4, we argue that the expertise in living well not only allows the wise person to assent correctly but also affects the content of her impressions. We suggest that these two models – one’s attitude toward an impression being informed by expertise, and one’s impressions being affected by expertise – might characterize distinct stages of cognitive development. Stoic wisdom is not only a matter of the way one assents to one’s impressions but also a matter of the condition of one’s soul and, consequently, of the kinds of impressions one even entertains. Expertise offers a model of how cognitive and discriminatory improvement through practice and effort can transform the non-wise into the wise. A reading on which the content of impressions is not exclusively propositional illuminates a further aspect of this transformation. If the same propositions are accessible through impressions with different non-propositional content, we can account for cases in which the novice and the expert entertain the same proposition.