bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning Image Processing Enables 40% Faster Spinal MR Scans Which Match or Exceed Quality of Standard of Care
Authors: Bash S. , Johnson B. , Gibbs W. , Zhang T. , Shankaranarayanan A. , Tanenbaum L. N. 
Published: November 2021

Abstract
Objective
This prospective multicenter multireader study evaluated the performance of 40% scan-time reduced spinal magnetic resonance imaging (MRI) reconstructed with deep learning (DL).

Methods
A total of 61 patients underwent standard of care (SOC) and accelerated (FAST) spine MRI. DL was used to enhance the accelerated set (FAST-DL). Three neuroradiologists were presented with paired side-by-side datasets (666 series). Datasets were blinded and randomized in sequence and left-right display order. Image features were preference rated. Structural similarity index (SSIM) and per pixel L1 was assessed for the image sets pre and post DL-enhancement as a quantitative assessment of image integrity impact.

Results
FAST-DL was qualitatively better than SOC for perceived signal-to-noise ratio (SNR) and artifacts and equivalent for other features. Quantitative SSIM was high, supporting the absence of image corruption by DL processing.

Conclusion
DL enables 40% spine MRI scan time reduction while maintaining diagnostic integrity and image quality with perceived benefits in SNR and artifact reduction, suggesting potential for clinical practice utility.
Cooperation by ant queens during colony-founding perpetuates alternative forms of social organization
Authors: Blacher Pierre , De Gasperin Ornela , Chapuisat Michel 
Published: November 2021

AbstractKey social traits, like queen number in eusocial insect colonies, have long been considered plastic, but the recent finding that colony social organization is under strict genetic control in multiple ant lineages challenges this view. This begs the question of which hardwired behavioral mechanism(s) generate alternative forms of social organization during colony development. We addressed this question in the Alpine silver ant,Formica selysi, a species with two social forms determined by a supergene. Queens that carry exclusively theMhaplotype are produced by and live in monogyne (= single-queen) colonies, whereas queens that carry at least one copy of thePhaplotype are produced by and live in polygyne (= multiple-queen) colonies. With extensive field samplings and laboratory experiments, we show that both types of queens successfully establish colonies independently, without being accompanied by workers, but that they do so in contrasting ways. Monogyne queens were generally intolerant of other queens and founded colonies solitarily, whereas polygyne queens were mutually attracted to each other and mainly founded colonies cooperatively. These associations persisted for months after worker emergence, suggesting that cooperative colony-founding leads to permanent multiple queening. Overall, our study shows that queens of each social form found colonies independently in the field but thatP-carrying queens are more likely to cooperate, thereby contributing to perpetuate alternative forms of social organization.Significance statementUnderstanding the genetic and behavioral underpinnings of social organization is a major goal in evolutionary biology. Recent studies have shown that colony social organization is controlled by supergenes in multiple ant lineages. But the behavioral processes linking the genotype of a queen to the type of colony she will form remain largely unknown. Here, we show that in Alpine silver ants, alternative supergene genotypes are associated with different levels of social attraction and tolerance in young queens. These hardwired differences in social traits make queens carrying thePsupergene haplotype more prone to cooperate and form durable associations during independent colony-founding. These findings help explain how genetic variants induce alternative forms of social organization during the ontogeny of a colony. They also illustrate how simple phenotypic differences at the individual level can result in large differences at higher levels of organization.
Impact of COVID-19 crisis on medical care of patients with metastasized uro-oncologic disease under systemic cancer therapy: a multicenter study in German university hospitals
Authors: Struck Julian P. , Schnoor Maike , Schulze Andrea , Hupe Marie C. , Ozimek Tomasz , Oppolzer Immanuel A. , Schnabel Marco J. , Burger Maximilian , Darr Christopher , Gruenwald Viktor , Hadaschik Boris , Weinke Maximilian , Kuebler Hubert , Klockenbusch Jonas C. , Grabbert Markus T. , Gratzke Christian , Kramer Mario W. , Katalinic Alexander , Merseburger Axel S. 
Published: November 2021

AbstractPurposeTo date, over 4.2 million Germans and over 235 million people worldwide have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Uro-oncology (UO) patients are particularly vulnerable but in urgent need of life-saving systemic treatments. Our multicentric study examined the impact of the COVID-19 crisis on the medical care of UO patients in German university hospitals receiving ongoing systemic anti-cancer treatment and to detect the delay of medical care, defined as deferred medical treatment or deviation of the pre-defined follow-up assessment.MethodsData of 162 UO patients with metastatic disease undergoing systemic cancer treatment at five university hospitals in Germany were included in our analyses. The focus of interest was any delay or change in treatment between February 2020 and May 2020 (first wave of the COVID-19 crisis in Germany). Statistical analysis of contingency tables were performed using Pearson’s chi-squared and Fisher’s exact tests, respectively. Effect size was determined using Cramér’s V (V).ResultsTwenty-four of the 162 patients (14.8%) experienced a delay in systemic treatment of more than 2 weeks. Most of these received immuno-oncologic (IO) treatments (13/24, 54.2%,p = 0.746). Blood tests were delayed or canceled significantly more often in IO patients but with a small effect size (21.1%,p = 0.042,V = 0.230). Treatment of patients with renal cell carcinoma (12/73, 16.4%) and urothelial carcinoma (7/32, 21.9%) was affected the most.ConclusionsOur data show that the COVID-19 pandemic impacted the medical care of UO patients, but deferment remained modest. There was a tendency towards delays in IO and ADT treatments in particular.
A healthy dietary pattern with a low inflammatory potential reduces the risk of gestational diabetes mellitus
Authors: Pajunen Lotta , Korkalo Liisa , Koivuniemi Ella , Houttu Noora , Pellonperä Outi , Mokkala Kati , Shivappa Nitin , Hébert James R. , Vahlberg Tero , Tertti Kristiina , Laitinen Kirsi 
Published: November 2021

Abstract
Purpose
An optimal diet for lowering the risk of gestational diabetes mellitus (GDM) is still to be defined, but may comprise of nutrient intakes, dietary patterns, diet quality, and eating frequency. This study was designed to investigate the contribution of diet in developing GDM in a comprehensive way.

Methods
The dietary intake of overweight or obese women, a risk group for GDM (n = 351), was assessed using 3-day food diaries and diet quality questionnaires in early pregnancy. Eating frequency and nutrient intakes were calculated, and dietary patterns identified using principal component analysis. The inflammatory potential of the diet was determined by calculating the dietary inflammatory index (DII®) and energy-adjusted DII (E-DII™). GDM was diagnosed with an oral glucose tolerance test at 24–28 gestational weeks.

Results
Higher adherence to ‘healthier dietary pattern’ characterized by consumptions of vegetables and rye bread associated with a reduced risk of GDM (adjusted OR 0.27, 95% CI 0.11–0.70). Higher E-DII score, indicating pro-inflammatory diet, was associated with a 27% higher risk of GDM (adjusted OR 1.27; 95% CI 1.08–1.49) for each E-DII point. In the evaluation of nutrient intakes, total fat, saturated fatty acids (SFAs), and trans fatty acids were higher and fiber lower in women developing GDM compared to women not developing GDM (all p < 0.05). Intakes of total fat, SFAs, and trans fatty acids were also significant predictors for GDM (all p < 0.05).

Conclusions
The results emphasize the importance of an overall healthy diet and limitation of foods with SFAs, and other nutrients with a high inflammatory potential in reducing the risk of GDM.

Trial registration
ClinicalTrials.gov Identifier: NCT01922791, August 14, 2013.
Establishing a risk assessment framework for point-of-care ultrasound
Authors: Conlon Thomas W. , Yousef Nadya , Mayordomo-Colunga Juan , Tissot Cecile , Fraga Maria V. , Bhombal Shazia , Suryawanshi Pradeep , Villanueva Alberto Medina , Siassi Bijan , Singh Yogen 
Published: November 2021

AbstractPoint-of-care ultrasound (POCUS) refers to the use of portable ultrasound (US) applications at the bedside, performed directly by the treating physician, for either diagnostic or procedure guidance purposes. It is being rapidly adopted by traditionally non-imaging medical specialties across the globe. Recent international evidence-based guidelines on POCUS for critically ill neonates and children were issued by the POCUS Working Group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC). Currently there are no standardized national or international guidelines for its implementation into clinical practice or even the training curriculum to monitor quality assurance. Further, there are no definitions or methods of POCUS competency measurement across its varied clinical applications.Conclusion: The Hippocratic Oath suggests medical providers do no harm to their patients. In our continued quest to uphold this value, providers seeking solutions to clinical problems must often weigh the benefit of an intervention with the risk of harm to the patient. Technologies to guide diagnosis and medical management present unique considerations when assessing possible risk to the patient. Frequently risk extends beyond the patient and impacts providers and the institutions in which they practice. POCUS is an emerging technology increasingly incorporated in the care of children across varied clinical specialties. Concerns have been raised by clinical colleagues and regulatory agencies regarding appropriate POCUS use and oversight. We present a framework for assessing the risk of POCUS use in pediatrics and suggest methods of mitigating risk to optimize safety and outcomes for patients, providers, and institutions.

What is Known:

• The use POCUS by traditionally non-imaging pediatric specialty physicians for both diagnostic and procedural guidance is rapidly increasing.

• Although there are international guidelines for its indications, currently there is no standardized guidance on its implementation in clinical practice.

What is New:

• Although standards for pediatric specialty-specific POCUS curriculum and training to competency have not been defined, POCUS is likely to be most successfully incorporated in clinical care when programmatic infrastructural elements are present.

• Risk assessment is a forward-thinking process and requires an imprecise calculus that integrates considerations of the technology, the provider, and the context in which medical care is delivered. Medicolegal considerations vary across countries and frequently change, requiring providers and institutions to understand local regulatory requirements and legal frameworks to mitigate the potential risks of POCUS.
Phenological response to temperature variability and orography in Central Italy
Authors: Cerlini P. B. , Saraceni M. , Orlandi F. , Silvestri L. , Fornaciari M. 
Published: November 2021

AbstractEven if the sensitivity of vegetation phenology to climate change has been accepted on global and continental scales, the correlation between global warming and phenotypic variability shows a modulated answer depending on altitude, latitude, and the local seasonal thermal trend. To connect global patterns of change with local effects, we investigated the impact of the observed signal of warming found in Central Italy on two different willow species, Salix acutifolia and Salix smithiana, growing in three phenological gardens of the International Phenological Gardens’ network (IPG) located in different orographic positions. The time series of temperatures and phenological data for the period 2005–2018 were analysed first to find trends over time in the three gardens and then to correlate the recent local warming and the change in the two species phenology. The results confirmed the correlation between phenological trends and local trend of temperatures. In particular: budburst showed a trend of advancement of 1.4 days/year on average in all three gardens; flowering showed a divergent pattern between the gardens of either advancement of 1.0 days/year on average or delay of 1.1 days/year on average; while senescence showed a delay reaching even 3.3 days/year, although significant in only two gardens for both species. These trends were found to be correlated mainly with the temperatures of the months preceding the occurrence of the phase, with a shift in terms of days of the year (DOY) of the two species. Our conclusion is that the observed warming in Central Italy played a key role in controlling the phenophases occurrences of the two willow species, and that the orographic forcing leads to the different shift in DOY of phenophases (from 5 to 20 days) due to the local thermal forcing of the three phenological gardens.
Challenges of Tunnelling in Volcanic Rock Masses
Authors: Villeneuve Marlène C. 
Published: November 2021

AbstractVolcanic rock masses exhibit temporal and spatial variability, even at the scale and duration of engineering projects. Volcanic processes are dynamic, resulting in rock masses ranging from high-porosity, clay-rich, fractured, and soil-like to low-porosity, high-strength, brittle, and massive. Based on a number of studies in a variety of geological settings, such as active and fossil geothermal systems, on the surface of active volcanoes and up to 3000 m below the surface, the work presented in this article shows the relationship between geological characteristics and mechanical parameters of volcanic rocks. These are then linked to the resultant challenges to tunnelling associated with the mechanical behaviour of volcanic rocks and rock masses, ranging from ductile failure such as squeezing and swelling to dynamic failure such as spalling and rockburst.This article highlights some of the key parameters that should be incorporated in site and laboratory investigations to build representative ground models in volcanic rocks and rock masses. Rock mass characterisation needs to address the highly variable and anisotropic nature of volcanic rocks, ranging from millimetre to decametre scale. Ground models must include not only the mechanical properties, such as strength and stiffness, of typical lab investigations, but also petrophysical properties, such as porosity, and geological conditions, such as alteration. Geomechanical characterisation of these rock masses requires an understanding of geological processes to select appropriate field, lab and design tools. In volcanic rocks, perhaps more than any other rock types, the geology is critical to characterising and understanding the behaviour in response to tunnelling.
Learning from text and video blogs: comprehension effects on secondary school students
Authors: Delgado P. , Anmarkrud Ø. , Avila V. , Altamura L. , Chireac S. M. , Pérez A. , Salmerón L. 
Published: November 2021

AbstractInformational video blogs are a popular method of communication among students that may be fruitful educational tools, but their potential benefits and risks remain unclear. Streaming videos created by YouTubers are often consumed for entertainment, which may lead students to develop habits that hinder in-depth information processing. We aimed to test this hypothesis by comparing students’ perceived attention to task, metacognitive calibration of their level of comprehension, and comprehension outcomes between reading text blogs and watching video blogs. We also examined the influence of notetaking. 188 lower secondary students read two text blog entries and watched two video blog entries, and completed a series of tasks. Results showed no statistically significant effect of blog format and notetaking on students’ perceived on-task attention, metacognitive calibration, and comprehension of blog entries. Nevertheless, we found a triple interaction effect of format, notetaking, and students’ reading comprehension on blog entry comprehension. Only students low in reading comprehension benefited from notetaking and only when they read the text blog entries. These results indicate that video blogs can be as suitable for learning as text blogs and that notetaking can help struggling readers overcome their difficulties when learning from text blogs but not from video blogs.
Causal Proportionality as an Ontic and Epistemic Concept
Authors: Harbecke Jens 
Published: November 2021

AbstractThis paper is concerned with the content of the causal proportionality constraint. It investigates two general versions of the constraint, namely “horizontal” and “vertical” proportionality. Moreover, it discusses whether proportionality is considered an ontic or an epistemic, i.e. explanatory, constraint on causation in the context of some of the most prominent theories of causation. The following main claims are defended: (1) The horizontal (HP) and the vertical version (VP) of the proportionality constraint are logically independent. (2) HP is implied by some prominent theories of causation, not by others. (3) None of the discussed popular theories of causation contradicts either HP or VP. (4) HP and VP are not ontic or epistemic principles as such; rather, whether they are ontic or epistemic depends on the theories chosen plus background assumptions about the existence of higher-level causes and their non-identity to lower-level ones.
They are Doing Well, but is it by Doing Good? Pathways from Nonpolitical and Political Volunteering to Subjective Well-Being in Age Comparison
Authors: Lühr Matthias , Pavlova Maria K. , Luhmann Maike 
Published: November 2021

AbstractWe investigated whether higher internal control beliefs (perceived control, political efficacy) and improved social relationships (lower loneliness, social support availability) mediated the associations between nonpolitical and political volunteering and subjective well-being (SWB; life satisfaction, emotional well-being). Moreover, we examined whether these effects differed between nonpolitical and political volunteering and across age groups. We conducted longitudinal multilevel regression analyses of data from the German Socio-Economic Panel (1985–2016) in younger (14–29, n = 7,547), middle-aged (40–50, n = 6,437), and older (65–75, n = 3,736) adults (see preregistration at https://osf.io/qk6mu). Significant effects on SWB emerged mainly in older adults who reported higher life satisfaction on occasions with more frequent nonpolitical volunteering than usual but lower life satisfaction on occasions with more frequent political volunteering. The negative effect of political volunteering was mediated by higher loneliness. In younger and middle-aged adults, mixed effects of nonpolitical and political volunteering on the mediating variables and no significant effects on SWB emerged. We discuss methodological, contextual, and life-stage explanations of our findings.
Validation of the National Health And Nutritional Survey (NHANES) single-item self-reported sleep duration against wrist-worn accelerometer
Authors: Lee Paul H. 
Published: November 2021

Abstract
Purpose and methods
This study aimed to validate the single-item sleep duration question used in the National Health And Nutritional Survey (NHANES), “How much sleep do you usually get at night on weekdays or workdays (hours)?”, against a wrist-worn accelerometer (ActiGraph GT3X +) in waves 2011–2012 and 2013–2014 among an adult population aged 20 or above (n = 8,438, mean age 49.7, 48% male).

Results
The accelerometer-measured and self-reported sleep duration were 6.01 (SD 1.48) and 6.88 (SD 1.40) h/day, respectively, representing a 0.87 h/day of over-reporting (SD 1.90, p < 0.001). Such an over-reporting was observed in all subgroups, where the over-reporting ranged from 0.72 (those aged 41–50) to 1.13 h/day (those aged 71 or above). The correlation between accelerometer-measured and self-reported sleep duration was low (ρ = 0.14, p < 0.001).

Conclusions
The associations between sleep duration and other health outcomes identified using NHANES data should be further tested using more accurate and valid measures of sleep duration.
COVID-19 Fear Among Pakistanis: Psychometric Evaluation of the Fear of COVID-19 Scale Using Item Response Theory and Confirmatory Factor Analysis
Authors: Ullah Irfan , Tahir Muhammad Junaid , Ali Sajjad , Waseem Rabia , Griffiths Mark D. , Mamun Mohammed A. , Lin Chung-Ying , Pakpour Amir H. 
Published: November 2021

Abstract
The Fear of COVID-19 Scale (FCV-19S) assesses the fear of the novel coronavirus disease 2019 (COVID-19) and has been translated and validated into over 20 languages. The present study conducted confirmatory factor analysis (CFA) and item response theory (IRT) analyses on the FCV-19S among a sample of 937 Pakistani adults (mean [SD] age of 25.83 [11.80] years; 537 [57.3%] females). The CFA and IRT confirmed the unidimensionality of the FCV-19S. The Likert-type scale used in the FCV-19S was supported by the proper threshold orderings. Additionally, no DIF contrast had an absolute value larger than 0.5 regarding the participants’ characteristics of gender, age, living status, and education in the IRT findings. The FCV-19S was found to be valid and reliable with strong psychometric properties among the Pakistani adult population.
Understanding and Responding to Substance Use and Abuse in the Palestinian Refugee Camps in Lebanon Prior to and During COVID-19 Times
Authors: Aaraj Elie , Haddad Patricia , Khalife Sara , Fawaz Mirna , Van Hout Marie Claire 
Published: November 2021

Abstract
Due to its geographical proximity to the Syrian conflict and the occupied territories, Lebanon has experienced an influx of refugees in recent times. Palestinian refugees are an identified key vulnerable population, with displaced communities increasingly experiencing camp insecurity, vulnerability to drug use and related health harms. A qualitative study consisting of in-depth interviews and focus group discussions (FGDs) was undertaken as part of a regional exercise investigating Palestinian community experiences of substance and drug use in refugee camps. Thematic analysis triangulated the perspectives of 11 professional stakeholders representing United Nations, human rights and non-governmental organizations (NGOs), and eight Palestinian community members. Emerging themes centered on the interplay between socio-economic instability, lack of law enforcement and camp governance contributing to concerning levels of familial, drug and camp violence, trafficking and availability of drugs. Transactional sex and the exploitation of women and children in drug dealing, diversification toward drug manufacture and dealing of drugs with the outside community were described. There is a lack of harm reduction and rehabilitation supports for those in need. This study highlights the complexities in tackling drug dealing and related criminal activity within refugee camps and humanitarian settings, and the vulnerabilities of those living within to harmful drug use.