bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ERP study on facial emotion processing in young people with subjective memory complaints
Authors: Perez Vanesa , Garrido-Chaves Ruth , Perez-Alarcón Mario , Paiva Tiago O. , Pulopulos Matias M. , Hidalgo Vanesa , Salvador Alicia 
Published: May 2021

AbstractSubjective memory complaints (SMCs) are commonly related to aging, but they are also presented by young adults. Their neurophysiological mechanisms are not thoroughly understood, although some aspects related to affective state have been mentioned. Here, we investigated whether facial emotion processing is different in young people with (n = 41) and without (n = 39) SMCs who were exposed to positive, negative, and neutral faces, by recording the event-related potential (ERP) activity. From the ERP activity, the N170 (an index of face processing) and the LPP (an index of motivated attention) components were extracted. Regarding the N170, results showed less amplitude for positive and neutral faces in the participants with SMCs than in those without SMCs. Moreover, women with SMCs displayed longer latencies for neutral faces than women without SMCs. No significant differences were found between the groups in the LPP component. Together, our findings suggest deficits in an early stage of facial emotion processing in young people with SMCs, and they emphasize the importance of further examining affective dimensions.
Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype
Authors: Sakabe Tomohiko , Wakahara Makoto , Shiota Goshi , Umekita Yoshihisa 
Published: May 2021

AbstractMammary serine protease inhibitor (maspin) is a tumor suppressor gene that is downregulated during carcinogenesis and breast cancer progression. While the nuclear localization of maspin is essential for tumor suppression, we previously reported that the cytoplasmic localization of maspin was significantly correlated with poor prognosis in breast cancer patients. To understand the mechanisms that underlie oncogenic role of cytoplasmic maspin, we studied its biological function in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus. In MDA-MB-231 cells, maspin overexpression promoted cell proliferation and cell invasion, whereas maspin downregulation resulted in the opposite effect. Further, we observed that SRGN protein levels were increased in MDA-MB-231 cells stably overexpressing maspin. Finally, maspin overexpression in MDA-MB-231 cells resulted in the N-cadherin and epithelial mesenchymal transition (EMT)-related transcription factors upregulation, and TGFβ signaling pathway activation. These results suggested that cytoplasmic maspin enhances the invasive and metastatic potential in breast cancer cells with aggressive phenotype by inducing EMT via SRGN/TGFβ axis. This study demonstrated a novel biological function of cytoplasmic maspin in progression of breast cancer cells with an aggressive phenotype.
Converting tabular data into images for deep learning with convolutional neural networks
Authors: Zhu Yitan , Brettin Thomas , Xia Fangfang , Partin Alexander , Shukla Maulik , Yoo Hyunseung , Evrard Yvonne A. , Doroshow James H. , Stevens Rick L. 
Published: May 2021

AbstractConvolutional neural networks (CNNs) have been successfully used in many applications where important information about data is embedded in the order of features, such as speech and imaging. However, most tabular data do not assume a spatial relationship between features, and thus are unsuitable for modeling using CNNs. To meet this challenge, we develop a novel algorithm, image generator for tabular data (IGTD), to transform tabular data into images by assigning features to pixel positions so that similar features are close to each other in the image. The algorithm searches for an optimized assignment by minimizing the difference between the ranking of distances between features and the ranking of distances between their assigned pixels in the image. We apply IGTD to transform gene expression profiles of cancer cell lines (CCLs) and molecular descriptors of drugs into their respective image representations. Compared with existing transformation methods, IGTD generates compact image representations with better preservation of feature neighborhood structure. Evaluated on benchmark drug screening datasets, CNNs trained on IGTD image representations of CCLs and drugs exhibit a better performance of predicting anti-cancer drug response than both CNNs trained on alternative image representations and prediction models trained on the original tabular data.
Comparison of the TightRope system versus hook plate in acute acromioclavicular joint dislocations: a retrospective analysis
Authors: Shen Guangsi , Sun Shengxuan , Tang Chengyang , Xie Ye , Li Liubing , Xu Wei , Xu Youjia , Zhou Haibin 
Published: May 2021

AbstractThis study compared the results of the minimally invasive coracoclavicular (CC) fixation with a single TightRope (MITR) procedure and the hook plate (HP) procedure for acute acromioclavicular (AC) joint dislocation treatment. Sixteen patients with a mean age of 44.9 ± 11 years were treated with the MITR procedure. Nineteen patients with a mean age of 40.2 ± 8.7 years were treated using the HP procedure. Clinical outcomes were evaluated with the Visual Analog Scale (VAS) for pain, Constant–Murley Score (CMS), and University of California at Los Angeles (UCLA) Shoulder score. Vertical displacement of the clavicle with reference to the height of the acromion was measured in standard anteroposterior radiographs. The mean follow-up was 27 months in the MITR group and 30 months in the HP group. No statistically significant differences were found between the MITR group and the HR group in terms of VAS score (0.4 ± 0.6 vs 0.7 ± 0.6, P = 0.138), UCLA Shoulder score (33.9 ± 2.5 vs 33.7 ± 1.5, P = 0.843), or CMS (95.7 ± 7.3 vs 93.7 ± 6.6, P = 0.400). No redislocation was identified in the HP group, while redislocation occurred in 1 of 16 (6.3%) patients in the MITR group. One patient in the HP group (5.3%) had acromial osteolysis, while no acromial osteolysis was found in the MITR group. No other adverse events, such as infections, tunnel widening, fractures, or implant-related complications, were observed. Both procedures provided satisfactory results. The HP procedure provided better reduction, while the MITR procedure provided a slightly lower tendency of pain. Long-term follow-up is needed to investigate the clinical outcomes and radiological outcomes of both groups.
Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels
Authors: Patel Bijal , Wonski Bryan T. , Saliganan Dan M. , Rteil Ali , Kabbani Loay S. , Lam Mai T. 
Published: May 2021

AbstractThe ideal engineered vascular graft would utilize human-derived materials to minimize foreign body response and tissue rejection. Current biological engineered blood vessels (BEBVs) inherently lack the structure required for implantation. We hypothesized that an ECM material would provide the structure needed. Skin dermis ECM is commonly used in reconstructive surgeries, is commercially available and FDA-approved. We evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to BEBVs. Alloderm was incorporated into our lab’s unique protocol for generating BEBVs, using fibroblasts to establish the adventitia. To assess structure, tissue mechanics were analyzed. Standard BEBVs without Alloderm exhibited a tensile strength of 67.9 ± 9.78 kPa, whereas Alloderm integrated BEBVs showed a significant increase in strength to 1500 ± 334 kPa. In comparison, native vessel strength is 1430 ± 604 kPa. Burst pressure reached 51.3 ± 2.19 mmHg. Total collagen and fiber maturity were significantly increased due to the presence of the Alloderm material. Vessels cultured for 4 weeks maintained mechanical and structural integrity. Low probability of thrombogenicity was confirmed with a negative platelet adhesion test. Vessels were able to be endothelialized. These results demonstrate the success of Alloderm to provide structure to BEBVs in an effective way.
A high‐gain circular polarization beam scanning transmit array antenna
Authors: Zeng Qingyun , Xue Zhenghui , Ren Wu , Li Weiming , Yang Shiyi 
Published: May 2021

AbstractA high‐gain circular polarization (CP) beam scanning antenna based on planar transmit array (TA) is proposed. The planar TA is implemented using rectangular patches and square rings, and it has different frequency responses to two orthogonal polarized incident waves owing to different phase distributions in x‐ and y‐direction. The TA can convert a linearly polarized spherical incident wave into a circularly polarized transmitted plane wave. In addition, beam scanning is achieved by in‐plane translation of the feed antenna. The procedure is demonstrated for high‐gain beam steering implementation operating in CP at the Ku‐band. Full‐wave simulation results demonstrate that the designed antenna enables elevation beam scanning from −33.6° to +33.6°, with a peak gain of 26.4 dBi. Scanning loss is better than 5 dB and the axis ratio remains below 3 dB for the entire scanning range in the frequency band of 13.9–14.9 GHz. Moreover, a prototype is fabricated and the measured results have good agreement with the simulated results, which confirms the feasibility of using this technology to achieve a high‐gain, CP, low‐cost and low cross‐polarization beam scanning antenna.
Messinstrumente zur Erfassung von Bindungsaufbau während Schwangerschaft und nach der Geburt (Teil 3 einer Serie zur psychologischen Diagnostik im Peripartalzeitraum)
Authors: Weigl Tobias , Garthus-Niegel Susan 
Published: May 2021

ZusammenfassungDer Bindungsaufbau von (werdenden) Müttern und Vätern zu ihrem Kind hat große Bedeutung für das psychische Wohlbefinden der Eltern und des Kindes. Dies gilt insbesondere dann, wenn bei den Eltern bereits psychische Beschwerden wie Depressionen vorhanden sind. Darüber hinaus können frühkindliche Bindungserfahrungen sowohl die psychische Gesundheit des Kindes als auch spätere Beziehungen beeinflussen. Klassische Verfahren der Bindungsforschung wie der Fremde-Situations-Test zur standardisierten Erfassung des Bindungserlebens sind jedoch für den klinischen Alltag in Neonatologie und Geburtshilfe nicht praktikabel, zumal hier v. a. das Bindungsverhalten des Kindes im Fokus steht. Zudem kann die Bindung zum ungeborenen Kind so nicht erfasst werden. Daher bieten sich zur Erfassung des elterlichen Bindungserlebens v. a. Fragebögen an. Sowohl für die Zeit der Schwangerschaft, als auch für den Postpartalzeitraum sind geeignete Instrumente vorhanden, die jedoch überwiegend für Frauen entwickelt wurden. Allerdings besteht bei den meisten Fragebögen Bedarf zur methodischen Weiterentwicklung, da Cut-off Werte sowie Normwerte z. T. bisher nicht etabliert wurden. Solche Werte dürften allerdings insbesondere in der Regelversorgung von Bedeutung sein. Insgesamt scheint die Erfassung des Bindungserlebens sinnvoll zu sein, damit rechtzeitig Unterstützung beim Bindungsaufbau gegeben oder in unterstützende Angebote vermittelt werden kann.
„Ich finde, das ist halt in vielen Punkten im Leben
wichtig“ – Subjektive Vorstellungen junger Erwachsener von
Teilhabe
Authors: Cytera Chirine , Thyen Ute 
Published: May 2021

Zusammenfassung
Ziel Die Studie untersucht die subjektiven Vorstellungen junger
Erwachsener von Teilhabe. Im Fokus stehen dabei deren Verständnis von
Teilhabe sowie Lebensbereiche, in denen diese von der Zielgruppe als bedeutsam
erlebt wird.
Methodik In leitfadengestützten Gruppeninterviews (N=6)
wurden 20 junge Erwachsene mit und ohne Beeinträchtigung zu ihren
Vorstellungen von Teilhabe befragt. Um auch schwerer beeinträchtigte
Personen indirekt einzuschließen, wurden zusätzlich deren
Stellvertreter in Einzelinterviews (N=3) befragt. Das Material wurde
mittels qualitativer Inhaltsanalyse nach Mayring ausgewertet.
Ergebnisse Teilhabe wird vielseitig und individuell unterschiedlich
verstanden. Sechs Aspekte einer Begriffsbestimmung konnten ermittelt werden:
Miteinander; soziale Einbindung/Teilnahme an der Gesellschaft;
Aufgeschlossenheit/Unvoreingenommenheit/Interesse; gleiche
Möglichkeiten/ Gleichbehandlung;
Entscheidungsfreiheit/Autonomie; Mitbestimmung/Mitsprache.
Teilhabe ist für die Befragten in sieben Lebensbereichen bedeutsam:
soziales Umfeld; Arbeit/Bildung; Freizeit; Medien; Mobilität;
Politik; Finanzen/Selbstverwaltung.
Schlussfolgerung In den komplexen Vorstellungen junger Erwachsener von
Teilhabe sind insbesondere soziale Aspekte sowie Gleichberechtigung und
Selbstbestimmung von Bedeutung. Teilhabe im Bereich Sexualität und neue
Medien wird ein entscheidender Wert beigemessen, weshalb diese vermehrt
Beachtung finden sollten. Die Lebensbereiche, in denen Teilhabe als relevant
beschrieben wird, können je nach Interessen des Individuums variieren,
was auf den subjektiven Charakter des Konzeptes hinweist und die Bedeutsamkeit
aufzeigt, die jeweiligen Vorstellungen und Präferenzen einer Person oder
Personengruppe zu berücksichtigen.
Prognostische Einflussfaktoren auf den Erfolg der Sialendoskopie bei Sialolithiasis
Authors: Giotakis Aris I , Fischlechner Rene , Dejaco Daniel , Gottfried Timo , Riechelmann Herbert 
Published: May 2021

Zusammenfassung
Hintergrund Der Erfolg der Sialendoskopie hängt von mehreren Faktoren ab. Im Jahr 2008 wurde die Lithiasis-Stenosis-Dilatation (LSD) -Klassifikation zur genaueren Beschreibung des Stein-Gang-Verhältnisses eingeführt. Neben dem Nutzen der LSD-Klassifikation untersuchten wir weitere prä- und intraoperativ erhobene Einflussfaktoren auf den Erfolg der Sialendoskopie bei Sialolithiasis.
Methode PatientInnen mit Sialolithiasis der Glandula submandibularis und Glandula parotis, die zwischen September 2018 und März 2020 eine primäre Sialendoskopie erhielten, wurden retrospektiv untersucht. Die Steingröße, Steinlokalisation und LSD-Klassifikation wurden unter anderem als prognostische Einflussfaktoren untersucht.
Ergebnisse Insgesamt wurden 37 PatientInnen retrospektiv untersucht. Eine erfolgreiche Steinextraktion wurde bei 12/37 (32 %) PatientInnen durchgeführt. Bei Erfolg betrug die mediane Steingröße 3,7 mm, verglichen mit 10 mm bei Misserfolg (Mann-Whitney-Test; p < 0,0001). Bei Erfolg waren 11/12 Steine distal lokalisiert, verglichen mit 13/25 proximal lokalisierten Steinen bei Misserfolg (Pearson-Chi-Quadrat-Test; p = 0,010). Bei Erfolg wurden 10/12 Steine als L1S0D0 klassifiziert, während 15/25 bei Misserfolg als L3aS0D0-Steine klassifiziert wurden (Pearson-Chi-Quadrat-Test; p = 0,001). Für distal lokalisierte Steine, die kleiner als 5 mm waren, lag die Erfolgsrate bei 100 %. Für proximal lokalisierte Steine, die größer als 4 mm waren, lag die Erfolgsrate bei 0 %. Für die als L1S0D0 klassifizierten Steine betrug die Erfolgsrate 60–100 %.
Schlussfolgerung Distal lokalisierte Steine und Steine kleiner als 5 mm in einem ansonsten unauffälligen Gangsystem können als prognostisch günstige Faktoren angesehen werden. Zukünftige Studien sollten anhand größerer Datenmengen die LSD-Klassifikation, das Volumen der Steine und deren Gangorientierung bzw. deren Abstand von der Papille untersuchen.
Green Aerobic Oxidation of Thiols to Disulfides by Flavin–Iodine Coupled Organocatalysis
Authors: Iida Hiroki , Oka Marina , Kozako Ryo 
Published: May 2021

AbstractCoupled catalysis using a riboflavin-derived organocatalyst and molecular iodine successfully promoted the aerobic oxidation of thiols to disulfides under metal-free mild conditions. The activation of molecular oxygen occurred smoothly at room temperature through the transfer of electrons from the iodine catalyst to the biomimetic flavin catalyst, forming the basis for a green oxidative synthesis of disulfides from thiols.
Clinical Efficacy of the Multilayered Skull Base Reconstruction Using In Situ Bone Flap in Endoscopic Endonasal Approach for Craniopharyngioma
Authors: Zhou Yuefei , Hei Yue , Soto Jose M. , Jin Tao , Jiang Xiaofan , Feng Dongxia , Liu Weiping , Gao Dakuan 
Published: May 2021

Abstract
Objective The aim of the study is to summarize and analyze the efficacy of the multilayered skull base reconstruction using in situ bone flap in endoscopic endonasal approach (EEA) for craniopharyngiomas.
Methods A retrospective review of 65 patients who underwent resection of their histopathology confirmed craniopharyngiomas performed at a single institution. Based on the team's understanding and mastery of skull base reconstruction techniques, patients were divided into two groups according to the methods of reconstruction in two periods. First (March 2015 through August 2016), osseous reconstruction was not adopted and served as the control group (34 cases). Second (September 2016 through July 2019), in situ bone flap repair of the skull base (complete osseous reconstruction) served as observation group (31 cases). The length of hospitalization and nasal exudation, bed rest time of hospital discharge, the incidence of cerebrospinal fluid leaks, lumbar drainage, and intracranial/pulmonary infections were collected and compared.
Results Compared with the control group, patients in the observation group had obviously less lumbar drainage and CSF leakage (p < 0.05), but had no significant difference in cases of re-operation, meningitis, and pulmonary infection. At the meantime, cases of nasal exudation, bed rest, and hospitalization of the observation group were significantly reduced (p < 0.05) in the observation group.
Conclusion The multilayered reconstruction technique (especially using in situ bone flap, combined with vascularized pedicled nasoseptal flap) is a safe and effective method in achieving watertight closure after EEEA, and can significantly reduce the incidence of cerebrospinal fluid leaks, and facilitate rehabilitation in skull base reconstruction of craniopharyngiomas.
Racial and Ethnic Disparities in Adverse Perinatal Outcomes at Term
Authors: Parchem Jacqueline G. , Rice Madeline Murguia , Grobman William A. , Bailit Jennifer L. , Wapner Ronald J. , Debbink Michelle P. , Thorp Jr John M. , Caritis Steve N. , Prasad Mona , Tita Alan T.N. , Saade George R. , Sorokin Yoram , Rouse Dwight J. , Tolosa Jorge E. ,   for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network
Published: May 2021

Objective This study aimed to evaluate whether racial and ethnic disparities in adverse perinatal outcomes exist at term.Study Design We performed a secondary analysis of a multicenter observational study of 115,502 pregnant patients and their neonates (2008–2011). Singleton, nonanomalous pregnancies delivered from 37 to 41 weeks were included. Race and ethnicity were abstracted from the medical record and categorized as non-Hispanic White (White; referent), non-Hispanic Black (Black), non-Hispanic Asian (Asian), or Hispanic. The primary outcome was an adverse perinatal composite defined as perinatal death, Apgar score < 4 at 5 minutes, ventilator support, hypoxic–ischemic encephalopathy, subgaleal hemorrhage, skeletal fracture, infant stay greater than maternal stay (by ≥ 3 days), brachial plexus palsy, or facial nerve palsy.Results Of the 72,117 patients included, 48% were White, 20% Black, 5% Asian, and 26% Hispanic. The unadjusted risk of the primary outcome was highest for neonates of Black patients (3.1%, unadjusted relative risk [uRR] = 1.16, 95% confidence interval [CI]: 1.04–1.30), lowest for neonates of Hispanic patients (2.1%, uRR = 0.80, 95% CI: 0.71–0.89), and no different for neonates of Asian (2.6%), compared with those of White patients (2.7%). In the adjusted model including age, body mass index (BMI), smoking, obstetric history, and high-risk pregnancy, differences in risk for the primary outcome were no longer observed for neonates of Black (adjusted relative risk [aRR] = 1.06, 95% CI: 0.94–1.19) and Hispanic (aRR = 0.92, 95% CI: 0.81–1.04) patients. Adding insurance to the model lowered the risk for both groups (aRR = 0.85, 95% CI: 0.75–0.96 for Black; aRR = 0.68, 95% CI: 0.59–0.78 for Hispanic).Conclusion Although neonates of Black patients have the highest frequency of adverse perinatal outcomes at term, after adjustment for sociodemographic factors, this higher risk is no longer observed, suggesting the importance of developing strategies that address social determinants of health to lessen extant health disparities.Key Points
The Caudal Septum Pivot Technique for Short Nose Correction
Authors: Marianetti Tito M. , Vellone Valentino , De Angelis Francesca , Ramieri Valerio 
Published: May 2021

AbstractThe short nose represents one of the greatest challenges in rhinoplasty. It is characterized by a reduced distance from the nasal radix to the tip-defining points, often associated with inadequate tip projection. Several techniques have been described for correction of short nose with the common objective of replacing and rebuilding the osteocartilaginous framework. One of the most effective method to correct the short nose is the septal extension graft. The authors describe the caudal septum pivot (CSP) technique, a simple method to elongate short noses by using a graft inserted in the dorsal septum after its division using as pivot the caudal portion, without detaching it from its natural anchorage to the anterior nasal spine. A retrospective analysis was performed reviewing the clinical charts and the operative records of 315 patients who underwent revision rhinoplasty from January 2015 to June 2019; among this group, 34 were considered eligible for the study. The patients (8 men, 26 women; mean age: 25.4 years; age range: 22–53 years) were divided into two groups: in 12 patients (Group 1) the CSP technique was performed, while Group 2 was composed of 22 patients who received a more classic treatment with a septal extension graft. To evaluate the outcomes, nasal length, tip projection, and tip rotation were measured pre- and 1 year postoperatively on digital photographs of each patient. Nasal anthropometric measurements revealed, at 12-month visit follow-up, an improvement in nasal length, tip projection, and nasolabial angle was achieved in all the patients. The comparison of the pre- and postoperative values showed a statistically significant reduction in the nasolabial angle (p < 0.05) and an increase in the tip projection (p < 0.05) and in the nasal lengthening (p < 0.05) in both groups. In authors' experience, the CSP technique could be considered a safe, reliable, and effective alternative technique in selected patients.