bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the implementation of a primary care intervention to reduce prescriptions of benzodiazepines (BENZORED IV)
Authors: Socias Isabel , Leiva Alfonso , Pombo-Ramos Haizea , Bejarano Ferran , Sempere-Verdú Ermengol , Rodríguez-Rincón Raquel María , Fiol Francisca , Mengual Marta , Ajenjo-Navarro Asunción , Pazo Fernando Do , Mateu Catalina , Folch Silvia , Alegret Santiago , Coll Jose Maria , Martín-Rabadán María , Vicens Caterina 
Published: March 2021

Abstract
Background: General practitioners (GPs) in developed countries widely prescribe benzodiazepines (BZDs) for their anxiolytic, hypnotic, and muscle-relaxant effects. Treatment duration, however, is rarely limited and this results in a significant number of chronic users. Long-term BZD use is associated with cognitive impairment, falls with hip fractures, traffic accidents, and increased mortality. The BENZORED IV trial was a hybrid type 1 trial conducted to evaluate the effectiveness and implementation of an intervention to reduce BZD prescription in primary care. The purpose of this qualitative study was to analyze facilitator and barriers to implement the intervention to primary care settings.Methods: Focus group meetings with GPs from the intervention arm of the BENZORED IV trial were held at primary healthcare centers in the three districts. For sampling purposes, the GPs were classified as high or low implementers according to the success of the intervention measured at 12 months. The Consolidated Framework for Implementation Research (CFIR) was used to conduct the meetings and to code, rate and analyze the dataResults: Three of the 41 CFIR constructs strongly distinguished between high and low implementers: The complexity in the intervention, the individual Stage of Change and the key stakeholder’s engagement. Seven constructs weakly discriminated between the two groups: the adaptability in the intervention, the external policy and incentives, the implementation climate, the relative priority, the self-efficacy and formally appointed implementation leader engaging. Fourteen constructs did not discriminate between the two groups, six had insufficient data for evaluation, and eleven had no data for evaluation.Conclusion: We identified constructs that could explain the variation in the implementation of the intervention, this information is relevant to design successful implementation strategies to implement the intervention.
Transient Silence of VvCSN5 Enhances Powdery Mildew Resistance in Grapevine (Vitis Vinifera)
Authors: Cui Kai-Cheng , Liu Min , Ke Gui-Hua , Zhang Xing-Yuan , Mu Bo , Zhou Min , Hu Yang , Wen Ying-Qiang 
Published: March 2021

Abstract
As one of the most economically important fruit crops in the world, grapevine (Vitis vinifera) suffers significant yield losses from many pathogens including powdery mildew caused by Erysiphe necator. By contrast, several wild Chinese grapevines including Vitis pseudoreticulata accession ‘Baihe-35-1’ exhibit a high resistance to powdery mildew pathogen. Here, we identified a grapevine gene CSN5 (COP9 signalosome complex subunit 5), designated VvCSN5, which showed different expression patterns in ‘Baihe-35-1’ and in susceptible cultivar V. vinifera ‘Thompson Seedless’ during powdery mildew isolate En NAFU1 infection. Moreover, transient silence of VvCSN5 in ‘Thompson Seedless’ leaves enhanced resistance to En NAFU1, which is accompanied by cell wall deposition at the attempt sites, and hypersensitive response-like cell death of penetrated epidermal cells. Several defense-related marker genes (VvPR1, VvPR3, VvPAD4, and VvRBOHD) had higher basal expression levels in VvCSN5-silenced leaves. In addition, we found the structure and activity of CSN5 promoters in ‘Thompson Seedless’ and ‘Baihe-35-1’ were discrepant, which may be one of the reasons for their different resistance to powdery mildew infection. Taken together, these results imply that grapevine CSN5 plays an important role in the responses to powdery mildew.
Unicompartmental Knee Arthroplasty Over the Past 40 Years: a Global Analysis and Review of the Most Highly Cited Articles
Authors: Jiang Buchan , Wei Cong , Zhang Wenchao , George Daniel M , Tang Ning , Huang Tianlong 
Published: March 2021

Abstract
Background: The aim of this study was to use citation analysis to identify the top 100 papers in unicompartmental knee arthroplasty (UKA) and report the qualities and characteristics of the most influential articles in UKA research.Methods: UKA–related articles published from 1950 to June 2020 were identified using multiple databases. The 100 most cited articles were selected for further analysis of citation count, citation density, current citation rate, authorship, theme, geographic distribution, level of evidence, and network analysis.Results: The top 100 articles' publication dates ranged from 1980 to 2015, with the largest number in the 2000s. Total citations per article ranged from 65 to 473. The USA was the most productive country, but England led the race in terms of citations. The Bone & Joint Journal was the most prolific journal with 25 articles. Price AJ was the most productive first author and corresponding author. The most popular study theme was therapeutic research, followed by prognostic research. The most common level of evidence was level IV. The network analysis connoted that follow-up study had the highest degree of centrality.Conclusions: The study of UKA is steadily evolving. It could be predicted that there will be an increasing number of publications on UKA research in the following years according to the current global trends, the United States and England will likely maintain leadership in this area. Meanwhile, further prospective studies are required to better recognize the prognosis of UKA procedures.
Differential Gene Expression in Patients With Prostate Cancer and in Patients With Parkinson Disease: an Example of Inverse Comorbidity
Authors: Pepe Pietro , Vetrano Simona , Cannarella Rossella , Calogero Aldo E , Marchese Giovanna , Ravo Maria , Fraggetta Filippo , Pepe Ludovica , Pennisi Michele , Romano Corrado , Ferri Raffaele , Salemi Michele 
Published: March 2021

Abstract
Prostate cancer (PCa) is one of the leading causes of death in Western countries. Environmental and genetic factors play a pivotal role in PCa etiology. Timely identification of the genetic causes is useful for an early diagnosis. Parkinson’s disease (PD) is the most frequent neurodegenerative movement disorder; it is associated with the presence of Lewy bodies (LBs) and genetic factors are involved in its pathogenesis. Several studies have indicated that the expression of target genes in patients with PD is inversely related to cancer development; this phenomenon has been named “inverse comorbidity”. The present study was undertaken to evaluate whether a genetic dysregulation occurs in opposite directions in patients with PD or PCa. In the present study, next-generation sequencing (NGS) transcriptome analysis was used to assess whether a genetic dysregulation in opposite directions occurs in patients with PD or PCa. The genes SLC30A1, ADO, SRGAP2C, and TBC1D12 resulted up-regulated in patients with PD compared to healthy donors as controls and down-regulated in patients with PCa compared with the same control group. These results support the hypothesis of the presence of inverse comorbidity between PD and PCa.
“Hesitating and puzzling”: The experiences and decision process of acute ischaemic stroke patients with prehospital delay after the onset of symptoms
Authors: Wang¹ pao yu , Tsao² Lee-Ing , Lin² Mei-Hsiang , Chen³ Yu-Wei , Lo⁴ Ying-Tao 
Published: March 2021

Abstract

Background
Despite campaigns to increase public awareness of stroke symptoms by advocating FAST(Face-Arms-Speech-Time), some stroke patients still show delays in the recognition of and response to stroke symptoms and miss the golden first 4.5 hours to receive rt-PA treatment. The aim of this study was to explore how acute ischaemic stroke patients with prehospital delay seek help and undergo the decision process before arriving at the hospital.
Methods
A qualitative approach using a grounded theory was applied. There were 24 ischaemic stroke patients recruited by purposive sampling.
Results
“Hesitating and puzzling” was the core category to describe and guide the process of acute ischaemic stroke patients with prehospital delay. During this process, “Sudden loss of physical limbs sensation and dysfunction” was identified as the antecedent condition. This process would be marked by action and interaction among the following categories: “Self-judgement and self-rationalization”, “Self-treatment and seek medical attention nearby”, “Puzzling and doubting-it may only be a minor problem”, “Worse symptoms” needing immediate advanced medical help and “Rush to nearby ER-self-alerting that serious disease is coming”. Eventually, the patients would be informed that they were admitted to the ER too late to receive rt-PA and would become sad, melancholy and regretful about becoming a disable person.
Conclusions
The study emphasizes the importance of educating the community residents about identifying stroke symptoms and seeking medical attention immediately. These results will assist the healthcare providers by offering references for designing patient-centric educational strategies for preventing stroke pre-hospital delay to improve the quality of stroke medical care.
The impact of quarantine&nbsp;duration on psychological outcomes and vaccination intention during the second outbreak of COVID-19 in China
Authors: Chen Lele , Xia Yuxin , Wang Dingding , Zhou Renlai 
Published: March 2021

Abstract
Objectives

A second outbreak of COVID-19 happened in China. We assessed the impact of quarantine duration on psychological outcomes and vaccination intention.
Methods

A cross-sectional online survey was employed. Participants were invited to complete the measurement of quarantine duration, social distancing, psychological distress, wellbeing (WHO-5), and vaccination intention. Multiple linear and logistic regression was used to examine the relationship between quarantine duration and social distancing, psychological distress, wellbeing, as well as vaccination intention.
Results

Of the 944 participants, 17.2% (7.8% quarantined for 1–7 days and 9.4% quarantined for > 7 days) of the sample have been quarantined. Quarantine for 1–7 days raised the social distancing(β = 2.61 95% CI 1.90–3.33) and vaccination intention (OR = 2.16 95% CI 1.22–3.82) .While quarantine for > 7 days was associated with the increases the social distancing(β = 3.00 95% CI 2.37–3.64) and psychological distress (β = 1.03 95% CI 0.22–1.86), and the decrease of wellbeing(β = 1.27 95% CI 0.29–2.26).
Conclusions

Longer quarantine duration reported a greater impact on social distancing and psychological distress, and a poorer wellbeing during the second COVID-19 pandemic. Quarantine for 1–7 days associated with the increase of vaccination intention. The duration of quarantine should be considered when preparing for immunization programs and preventing psychological disorders during COVID-19 pandemic.
Humour styles influence the perceived valence, humour, and beneficial use of depressive internet memes in depression
Authors: Akram Umair , Gardner Kathryn , Drabble Jennifer , Jabs Nicola-Maria 
Published: March 2021

Abstract
Previous research highlights the potential benefits of engaging with depressive internet memes for those experiencing symptoms of depression, a phenomenon that can be explained in part by the humorous interpretation of depressive stimuli and a perceived sense of social support through the normalisation of depressive symptoms. This study examined whether individuals experiencing significant depressive symptoms would differ from controls in their interpretation of internet memes related to depression, whilst incorporating the mediating role of humour style. N = 78 individuals with self-reported depressive symptoms (indicating ≥24 on the CES-D) and 67 controls (indicating ≤23) rated the emotional valance, humour, relatability, shareability, and mood improving potential of 32 depressive and control internet memes (depicting general neutral or positive social commentaries). Measures of depression and humour style were also completed. The perception of humour, relatability, shareability and mood improving potential of depressive, but not control, memes were all greater amongst individuals with symptoms of depression relative to controls. However, for ratings of humour, relatability and mood improving potential, these differences were mediated by the extent of ones self-defeating humour style. These outcomes further evidence benefits of engaging with depressive internet memes for those with depression.
Morphology, development stages, and phylogeny of the Rhabditolaimus ulmi (Nematoda: Diplogastridae), a phoront of the bark beetle Scolytus multistriatus from the elm Ulmus glabra Huds. in Northwest Russia
Authors: Ryss Alexander Y. , Polyanina Kristina S. , Álvarez-Ortega Sergio , Subbotin Sergei A. 
Published: March 2021

Abstract
The nematode Rhabditolaimus ulmi was found in galleries, adults, and larvae of Scolytus multistriatus, the vector of the Dutch elm disease, in St. Petersburg parks. This nematode co-occurred with Bursaphelenchus ulmophilus, which is another phoretic partner of S. multistriatus. Nematodes were cultured on the fungus Botryotinia fuckeliana in potato sugar agar (PA) and used for morphological analyses of adults, juveniles, eggs, and dauers. Nematode females showed a didelphic female genital tract rather than a monoprodelphic gonad as reported in the original description. Male bursa peloderan, caudal papillae include three preanal pairs and one precloacal unpaired papillae; seven postanal papilla pairs, among which one is pore-like and possibly the phasmid homolog, one subdorsal, and a pair of three closely situated posteriorly at bursa alae. The juvenile stages differ in size and structure of their sexual primordia. Sex of juveniles may be identified from the third stage. The dauer juvenile is a phoretic third juvenile stage (DJ3), which enters and remains localized in the buccal cavity of beetle adults and last-instar larvae and also under the elytra and in the ovipositor’s cavity of pupae and imagoes. The first molt J1-J2 occurred inside the eggshell. Adult females laid eggs in early stages of embryonic development or containing molted J2. The propagative non-phoretic J2 inside the egg and J3 have a long and well-developed median bulb. The phoretic dauer DJ3 has a small spherical bulb like the J1 juvenile within the egg. In a sterile fungal culture, the nematodes feed on both mycelium and their unidentified ecto-symbiotic bacteria, located on nematode surface coat and multiplying in PA. Diagnosis and tabular key to the Rhabditolaimus species are given. Phylogenetic analysis of the D2-D3 of 28S rRNA gene sequences resulted in the Bayesian consensus tree with the highly supported clade of the Rhabditolaimus species.
Withdrawal Notice: Involvement of the Gut-brain Axis in Neurological Disorders
Authors: Kaushal Swati , Singh Charan , Singh Arti 
Published: March 2021

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Feasibility and Convergent Validity of an Activity Tracker for Low Back Pain Within a Clinical Study: Cross-sectional Study
Authors: Zhuo Linda Xiaoqian , Macedo Luciana Gazzi 
Published: March 2021

Background
Low back pain (LBP) is a highly prevalent condition affecting individuals of all ages. To manage the symptoms and prevent recurrences and flare-ups, physical activity in conjunction with self-management education is recommended. Tools such as diaries and questionnaires have been the gold standard for tracking physical activity in clinical studies. However, there are issues with consistency, accuracy, and recall with the use of these outcome measures. Given the growth of technology in today’s society, consumer-grade activity monitors have become a common and convenient method of recording physical activity data.

Objective
The aim of this study is to test the feasibility and convergent validity of a Garmin Vivofit 3 activity tracker in evaluating physical activity levels in a clinical trial of patients with LBP.

Methods
We recruited 17 individuals with nonspecific LBP referred from health care professionals or self-referred through advertisements in the community. The participants entered into a 12-week physical activity and self-management program. Physical activity was assessed using a self-reported questionnaire and the Garmin activity tracker. Activity tracker data (eg, steps taken, distance walked, and intensity minutes) were extracted weekly from the Garmin Connect online platform. Outcomes of pain and activity limitation were assessed weekly using a mobile app. A linear regression was conducted to evaluate if demographic factors (ie, age, gender, pain level) affected the adherence rates to the activity monitor. We also used Pearson correlations to evaluate the convergent validity of the Garmin activity tracker with the physical activity questionnaire.

Results
The mean daily adherence rate for activity monitors was 70% (SD 31%) over the 26 weeks of study. The mean response rate for the weekly physical activity measures using REDCap for the first 12 weeks of the study was 91% (SD 17%). None of the hypothesized variables or questionnaires were predictors of response rate.

Conclusions
The majority of participants were compliant with wearing the tracker, and demographic factors were not found to be predictors of adherence to wearing the device. However, there were poor correlations between the modified International Physical Activity Questionnaire Short Form (IPAQ-SF) and the activity monitor, demonstrating problems with convergent validity.
Revisitando el discurso eugenésico argentino (1932 - 1943)
Authors: Dalmau Iván Gabriel 
Published: March 2021

El propósito de este trabajo es llevar a cabo una lectura en clave biopolítica del discurso eugenésico (Argentina, 1932 - 1943). Por lo tanto, pondremos el foco de nuestra lectura en la problematización del capital humano. Analizaremos, entonces, ciertas propuestas políticas concernientes al cuidado de dicho capital.
Prensa, dictadura e Iglesia católica
Authors: Farías Roxana Janet , Navarrete Marcela Haydeé , Martínez Cintia Débora 
Published: March 2021

El problema investigado en este artículo es la construcción de verdad que realizan dos soportes de prensa locales, El Diario de San Luis (EDSL) y La Opinión (LO), en torno a la última dictadura cívico-militar en las noticias cuya fuente de información principal es el Obispado de San Luis. El análisis abarca el periodo comprendido entre enero de 1976 y agosto de 1977.
En cuanto a los aspectos metodológicos, este trabajo se inscribe en un análisis interpretativo, a partir de categorías que provienen de la Sociosemiótica y de la Translingüística.
The changing map of subnational governance in the Republic of Ireland
Authors: Breathnach Proinnsias , O’Mahony Eoin , van Egeraat Chris 
Published: March 2021

Abstract
The evolution of the territorial structure of Ireland’s system of local government during the period of colonial rule by England is outlined. The independence period saw little change in this structure until the abolition of municipal-level government in 2014, reflecting the very marginal role of devolved administration in Ireland’s political system. The creation and functioning of regional-level administrative systems, mainly related to the management of EU Structural Fund expenditure, are reviewed. Regional assemblies, established in 2015, have the role of preparing regional strategies under the 2018 National Planning Framework. Ongoing problems arising from a mismatch between subnational governance systems and underlying socio-spatial structures are discussed.
Cartesian space robot manipulator clamping movement in ROS simulation and experiment
Authors: Mu Longtao , Zhou Yunfei , Zhao Tiebiao 
Published: March 2021

Abstract
This paper studies the robot arm sorting position control based on robot operation system (ROS), which works depending on the characteristics of the robot arm sorting operation using the top method, to automate the sorting operation and improve the work efficiency of workpiece sorting. Through the ROS MoveIt! module, the sorting pose and movement path of the robotic arm are planned, the inverse kinematics of the sorting robotic arm is solved, and the movement pose characteristics of the sorting robotic arm are analysed. The robot arm model was created using Solidworks software, and the URDF model file of the robot arm was exported through the sw2urdf plugin conversion tool, and the parameters were configured. Based on ROS for 6-degree-of-freedom (DOF) robot motion simulation, random extended tree (RRT) algorithm from open motion planning library (OMPL) is selected. The robot motion planning analysis and sorting manipulator drive UR5 manipulator. The results show that the sorting pose and motion trajectory of the robot arm are determined by controlling the sorting pose of the sorting robot arm, and the maximum radius value of the tool centre point (TCP) rotation of the robot arm and the position of the workpiece are obtained. This method can improve the success rate of industrial sorting robots in grabbing objects. This analysis is of great significance to the research of robots’ autonomous object grabbing.
Alveolar echinococcosis of the liver with a rare infiltration of the adrenal gland
Authors: Šimeková K. , Rosoľanka R. , Szilágyová M. , Antolová D. , Nováková E. , Novák M. , Laca Ľ. , Sadloňová J. , Šoltys J. 
Published: March 2021

Summary
Human alveolar echinococcosis (AE) is a silently-progressing disorder that has become a threat in many countries. Since 2000, when the first case was recorded, the number of human AE patients in Slovakia is on continuous raise. The article presents a rare case of alveolar echinococcosis with infiltration in the adrenal gland and discusses the problems associated with differential diagnosis of the disease. In 2016, abdominal ultrasound performed due abdominal pain complaint showed the presence of cystic lesions in the right liver lobe of 54-year old female patient. During surgery, another lesion in the right adrenal gland was found, and neoplastic processes or echinococcosis were considered in the differential diagnosis. Due to unclear correlation between radiology, serology and histopathology results and endemic situation in Slovakia, molecular examination was recommended. Subsequently E. multilocularis was confirmed as etiological agent of infection. Alveolar echinococcosis is considered as a rare disease, with very few patients referred to clinicians or hospitals that sometimes have almost none existing experience with the diagnosis and treatment of the disease. Therefore, the establishment of networks or reference centres specialized on management of the disease would be suitable way to provide the patients with the best care and improve the disease diagnosis, treatment and prognosis.