bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Value of CT Angiography (CTA) in Carotid Cavernous Fistula (CCF) Patients Using the Digital Subtraction Angiography (DSA) as The Gold Standard: Observation in Dr. Soetomo General Hospital Surabaya from January 2016 to July 2020
Authors: Amalia Laila , Hartono Yudi Sarastika  , Bambang Soeprijanto  
Published: December 2021

Background: CT angiography (CTA) is the initial modality for diagnosing the Carotid Cavernous Fistula (CCF), identifying the type of CCF, measuring the diameter of the fistula and the diameter of the internal carotid artery (ICA) pre and post fistula, and then confirmed by Digital Subtraction Angiography (DSA) as the gold standard. CTA is expected to provide more information to improve the accuracy of CCF diagnosis to benefit therapy and prevent complications. This study aimed to determine the diagnostic value of CTA in CCF patients in Dr. Soetomo General Hospital Surabaya, using the DSA as a gold standard.
Methods: An observational retrospective study of CCF patients met the inclusion and exclusion criteria and underwent CTA and DSA examinations at the Radiology Installation of Dr. Soetomo General Hospital, Surabaya, from January 2016 to July 2020.
Results: In the comparison of types of CCF CTA to DSA, the direct group was 53.8% and 57.7%, respectively, while the indirect group was 46.1% and 42.3% with a very strong correlation (κ = 0.922; p = 0.000), sensitivity was 93.3%, specificity was 100 %, PPV of 100%, NPV of 91.7% and accuracy of 96.15%. Direct type evaluation on the DSA showed a large picture of the fistula diameter; the ICA pre fistula's size was enlarged; therefore, the ICA post fistula diameter was reduced or absent. There was a strong correlation of fistula diameter measurement results between CTA and DSA (r = 0.695, p = 0.006).
Conclusion: CTA has a similarity rate of 92.2% with DSA in identifying the type of CCF. The accuracy value of CTA is close to DSA in fistula diameter measurements.
Efficacy of Calcipotriol 0.005% Ointment for Uremic Xerosis with Pruritus in Chronic Kidney Diseases Undergoing Hemodialysis Patients: Randomized Double Blind Clinical Trial
Authors: Widyastuti  , Yahya Yulia Farida , Suroso Adi Nugroho  , Soenarto Kartowigno  , M. Izazi Hari Purwoko  , Irsan Saleh  
Published: December 2021

Introduction: Uremic xerosis with pruritus (UXP) is a chronic cutaneous complication among patients undergoing maintenance renal dialysis. Uremic xerosis level is directly related with pruritus severity or vice versa. Uremic xerosis with pruritus may lead to discomfort and negative psychological effect. The ethiopathogenesis still unknown, Most of treatments are empirical, and there is no effective and safe therapy. Emollient has not been effective enough to improve quality of life. There is some report about efficacy of topical vitamin D in xerosis and chronic pruritus.
Objective: We evaluate the efficacy of calcipotriol 0.005% ointment for uremic xerosis and uremic pruritus in chronic kidney disease patients undergoing hemodialysis.
Material & methode: Sixty two patients with UXP were enrolled, randomized double blind study. Patients were divided to two group, calcipotriol 0.005% ointment group or placebo. In baseline, patients were instructed to apply twice daily for four weeks. We assesesment the efficacy and safety of calcipotriol 0.005% ointment and placebo after 2nd and 4th weeks treatment using overall dry skin score (ODSS), visual analog scale (VAS), corneometer and sebumeter. We also assessed adverse effect and tolerance this drugs using visual assessment scale.
Results: Overall dry skin score (ODSS) and visual analog scale (VAS) significantly decreased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Skin hydration level based on Corneometer score and skin surface lipid based on Sebumeter score was significantly increased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Cure rate and clinical improvement for calcipotriol 0.005% ointment group was significantly higher than placebo group. There was no adverse effect between two groups after treatment.
Conclusion: calcipotriol 0.005% ointment is effective than placebo and can be used as alternative or adjuctive treatment and safe and tolerance for UXP.
Profile of Patients with Gaster Perforation at Dr. Moewardi General Hospital Surakarta in The Period of January-December 2018
Authors: Zaini Imam Hafidh , Ida Bagus Budhi  
Published: December 2021

Introduction: A gastric perforation is a form of hollow digestive organ perforation in which the entire thickness of the stomach wall is injured. Perforation of hollow organs can be suspected based upon the clinical picture, and the diagnosis becomes obvious through an image of free air on imaging performed.
Methods: Data of patient characteristics were observed retrospectively from medical records of patients diagnosed with gastric perforation between January and December 2018.
Results: Between January and December 2018, 45 patients with gastric perforation were identified, with data distributed by gender. There were 36 women (80%) and 9 men (20%) in the group. Based on the age group, 32 patients (71%) were distinguished by the age group over 40 years and 13 patients (29 %) under 40 years of age. When viewed from the location of the gastric perforations, it was found that 4 patients (9%) had a perforation in the antrum, 36 patients (80%) in the Prepylorus, and 5 patients (11.2%) in the major curvature. Data on analgesic use revealed 32 patients (71%) had a history of taking analgesics and 13 patients (29%) without a history of taking analgesics.
Conclusion: In 2018, the majority of gastric perforation patients at Dr. Moewardi Hospital were female (80%), with the highest age group being over 40 years (71%) and the most gastric perforations occurring in the pylori (80%). The number of patients with gastric perforation who had previously used herbs and analgesics was higher (70%) than those who had not. Thus, the results of this retrospective study are consistent with previous research findings and can be used to continue research into the relationships (correlations) between the aforementioned variables.
Contamination of Soil Transmitted Helminths (STH) Eggs in Raw Vegetables at Street Food Stalls and Restaurant in Lorok Pakjo Village, Palembang
Authors: Leo Medianto Faziqin  , Dalilah  , Dwi Handayani  , Chairil Anwar  , Susilawati  
Published: December 2021

Background: Infection Soil Transmitted Helminths (STH) is a disease that is a problem in the world, especially in areas with a tropical climate like Indonesia. This infection can be transmitted through consumption of raw vegetables contaminated with STH. This study aims to determine whether there is contamination of STH eggs in raw vegetables at street food stalls and restaurants in Lorok Pakjo Village, Palembang.
Methods: This research is a descriptive observational study. Samples in the form of fresh vegetables were collected from 18 street stalls and 14 restaurants in Lorok Pakjo Village, Palembang. Samples were examined using the sedimentation method and observed using a microscope.
Results: The results obtained 80 samples consisting of 30 cabbage, 18 basil, 30 cucumber, 1 lettuce, and 1 eggplant. Of the 80 samples, there were 20 (25%) positive samples contaminated with STH eggs consisting of 8 (10%) cabbage samples, 8 (10%) basil samples, 4 (5%) cucumber samples, and no STH contamination was found in lettuce. and eggplant. Of the 20 positive samples of STH contamination, 12 samples came from street vendors consisting of 5 (10.6%) cabbage samples, 6 (12.8%) basil samples, and 1 (2.1%) cucumber samples. While the other 8 samples came from restaurants consisting of 3 (9.1%) cabbage samples, 2 (6%) basil samples, and 3 (9.1%) cucumber samples. Found only eggs of Ascaris lumbricoides infertile decorticate in all samples consisting of 9 eggs on cabbage, 16 eggs on basil, and five eggs on cucumber.
Conclusion: There is contamination of eggs Soil Transmitted Helminths in raw vegetables in street food stalls and restaurants in Lorok Pakjo Village, Palembang.
Khilafah Dalam Kajian Al-Quran Dan Historis: Rekonstruksi Hukum Khilafah Islamiyah
Authors: Prasetyo Aldi , Mukhtar Naqiyah , Qiptiyah Maryatun 
Published: December 2021

Rekonstruksi khilafah merupakan wacana dunia yang merebah di berbagai negara. Semangat ini berawal dari flashback sejarah emas umat Islam di bawah naungan sistem khilafah. Banyaknya pro-kontra yang terjadi di kalangan umat Islam membuat tidak kunjung terealisasinya rekonstruksi khilafah di berbagai negara. Hal itu menunjukan adanya perbedaan pemahaman umat Islam terkait sistem khilafah. Tujuan penelitian ini yaitu menemukan dasar hukum rekonstruksi khilafah di zaman modern. Bertolak dari Al-Quran dan sejarah, peneliti mencoba menemukan dasar hukum rekonstruksi khilafah yang telah usang dimakan zaman. Berdasarkan hasil studi hermeneutik serta analisis sejarah, peneliti menyimpulkan bahwa upaya rekonstruksi khilafah tidak mempunyai dasar yang kuat. Hal itu dapat ditelisik dari istilah khilafah itu sendiri yang secara tertulis tidak ditemukan dalam Al-Quran. Sedangkan kata yang berhubungan seperti kata kholaaif, khulafaa, dan kholifah merujuk pada makna regenerasi kelompok atau umat yang sama sekali tidak merujuk pada sistem pemerintahan. Sedangkan kata kholifah pada surat Shad ayat 26, cenderung menerangkan tentang karakter seorang pemimpin pada umumnya. Disisi lain penolakan sistem khilafah di berbagai negara dipicu oleh tidak adanya sistem baku yang dapat dijadikan patokan upaya rekonstruksi khilafah. Disamping itu, banyaknya sisi kelam yang menyertai sejarah khilafah dianggap khilafah bukan satu-satunya jalan untuk dapat menerapkan syariat Islam.
Persepsi, Pengambilan Keputusan, Konsep diri dan Value
Authors: Hakim Firdayanti B , Yunita Puteri Eka , Supriyadi Dedi , Isbaya Isbaya , Ramly Amir Tengku 
Published: December 2021

Dalam sebuah organisasi yang terdiri dari berbagai macam orang dengan berbagai macam karakter yang berbeda, akan mengakibatkan kumpulan interaksi yang menciptakan sebuah budaya organisasi yang khas. Persepsi anggota organisasi berbeda-beda sesuai dengan motivasinya, demikian juga degan konsep diri dan value pada tiap individu akan menentukan bagaimana sebuah keputusan organisasi diambil. Organisasi yang ingin mencapai tujuannya secara efektif dan efisien harus bisa mengontrol factor-faktor yang mempengaruhi kualitas dari persepsi, konsep diri dan value dari tiap individu. Sehingga dapat memimimalisir konflik dan dapat mencapat tujuan organisasi sesuai yang direncanakan.
Model Pembangunan Keusahawanan Asnaf Luar Bandar
Authors: Arif Mohd Izzat Amsyar Mohd 
Published: December 2021

Usahawan dikenali sebagai pemacu pertumbuhan ekonomi yang penting dan memberi nilai yang besar kepada ekonomi setempat. Zakat merupakan mekanisme yang digunakan untuk membantu golongan yang kurang bernasib baik dan miskin bagi memenuhi keperluan asas dan meningkatkan kualiti hidup mereka. Dengan menentukan faktor kritikal, kajian ini bertujuan untuk menyelidiki model multidimensi yang dapat digunakan dalam program pembangunan bagi memenuhi keperluan usahawan asnaf luar bandar. Kajian ini menggunakan reka bentuk penyelidikan kualitatif yang merangkumi pengumpulan data melalui kaedah perpustakaan dan analisis data secara deskriptif. melalui sorotan literatur, konsep dan tema kajian ditetapkan dan dianalisis. Dapatan kajian menunjukkan bahawa untuk menjadikan asnaf seorang sahawan yang berjaya, semua faktor kritikal mesti dititikberatkan, terutama di kawasan luar bandar. Di akhir kajian, dicadangkan sebuah model komprehensif bagi pembangunan keusahawanan asnaf luar bandar.

Entrepreneurs are known as important drivers of economic growth and add considerable value to local economies. Zakat is one of the tools used to help disadvantaged and impoverished people meet their basic needs and improve their quality of life. By defining the critical factors, this study aims to investigate a multidimensional model that can be used in development programmes to meet the needs of rural asnaf entrepreneurs. This study uses a simple qualitative research design that includes data collection through library methods and descriptive analysis. The findings from previous studies were analysed to establish the concept and theme of the analysis. Finally, it is discovered that in order to turn an asnaf into a successful entrepreneur, all of the critical factors must be emphasised, especially in rural areas. As a result, a detailed model for the growth of rural asnaf entrepreneurship is proposed.
Kerangka Pembangunan Insan Dalam Mengupaya Keusahawanan Asnaf: Rasulullah SAW Sebagai Model Usahawan
Authors: Arif Mohd Izzat Amsyar Mohd 
Published: December 2021

Usahawan asnaf dapat diklasifikasikan sebagai asnaf fakir dan miskin yang didedahkan dengan kemahiran dan kecenderungan dalam bidang keusahawanan. Bantuan modal yang diterima oleh institusi zakat membolehkan mereka berkecimpung dalam bidang perniagaan, sekaligus bertujuan untuk menjadikan asnaf sebagai pengeluar zakat. Justeru, artikel ini membincangkan aspek yang dapat diteladani oleh usahawan asnaf berpandukan perjalanan sirah Nabi Muhammad SAW sebagai peniaga dan pedagang yang berjaya. Kajian merumuskan bahawa kualiti peribadi berpandukan agama adalah amat penting membangunkan dan merealisasikan keusahawanan asnaf yang berjaya.

Asnaf entrepreneurs can be classified as poor and needy asnaf who are exposed to skills and inclinations in the field of entrepreneurship. The capital assistance received by zakat institutions enables them to engage in business, at the same time aiming them later to transform into producers of zakat. Thus, this article discusses the aspects that can be emulated by asnaf entrepreneurs based on the historical journey of the Prophet Muhammad SAW as a successful trader. The study concludes that religiously-guided personal qualities are very important in developing and realizing successful asnaf entrepreneurship.
ELIMINATION OF THE PESTILENCE (PLAGUE) OUTBREAK IN MOSCOW IN THE XVIII CENTURY: HISTORICAL AND LEGAL ASPECTS
Authors: ИСХАКОВ Эдуард Робертович 
Published: December 2021

Taking into account the historical experience of eliminating epidemics of particularly dangerous infections is relevant for the design and implementation of measures in the modern period, when the main challenge at the beginning of this century is the coronavirus pandemic. The purpose of the study is to identify the features of regulatory legal acts aimed at eliminating the plague outbreak in Moscow in the 18th century. Methods: the author uses analytical and bibliographic methods (scientific literature on the plague epidemic in Moscow in the 18th century and normative legal acts are analyzed). Results: the paper shows the role of the main liquidator of the epidemic – Count G. Orlov, who, along with additional prohibitive and restrictive measures, introduced financial support for patients and persons in quarantine, as well as health care institutions, which made it possible to eliminate the epidemic in almost two months and prevent its spread throughout the Empire. The measures to eliminate the plague were based on the opinion of leading Russian doctors that the plague is a disease that is transmitted by contact, which was scientific progress.
A política educacional e o ensino remoto na educação infantil em Fortaleza em época de pandemia: relato de experiência
Authors: Mendonça Gilzélia Cristina Pereira de , Gonçalves Gabriel Coutinho , Almeida Dennys Ramon de Melo Fernandes 
Published: December 2021

O ano de 2020 surpreendeu o mundo pela força tempestuosa da pandemia da Covid-19. Em meados de março do corrente ano, o novo coronavírus chega ao Brasil e toda a dinâmica da vida em sociedade passa por grandes e necessárias mudanças, adotando novas formas de ser e estar no mundo. O país vem, ao longo desse período, enfrentando diversos problemas de ordem social, política, econômica e cultural, gerando consequências complexas, principalmente em assegurar o direito subjetivo à educação pública de qualidade, como expressa o artigo 5º da Lei de Diretrizes e Bases da Educação Nacional (LDB), Lei n.º 9.394/1996. Nossa proposta é apresentar um relato de experiência sobre o ensino remoto na educação infantil em Fortaleza no ano de 2020, abordando os desafios e as conquistas da política educacional em período de pandemia. A primeira etapa da educação básica, segundo determina o artigo 29 da LDB, define que a educação infantil tem por foco o desenvolvimento integral da criança de até cinco anos, em seus aspectos físico, psicológico, intelectual e social, complementando a ação da família e da comunidade. O relato de experiência elegeu destacar as ações que foram realizadas nessa etapa de ensino da rede municipal de Fortaleza, no período de isolamento social referente ao ano de 2020.
Effect of pH on the Electrochemical Behavior of Hydrogen Peroxide in the Presence of Pseudomonas aeruginosa
Authors: Espinoza-Vergara Javier , Molina Paulo , Walter Mariana , Gulppi Miguel , Vejar Nelson , Melo Francisco , Urzua Marcela , Muñoz Hugo , Zagal José H. , Zhou Xiaorong , Azocar Manuel I. , Paez Maritza A. 
Published: December 2021

The influence of pH on the electrochemical behavior of hydrogen peroxide in the presence ofPseudomonas aeruginosawas investigated using electrochemical techniques. Cyclic and square wave voltammetry were used to monitor the enzymatic activity. A modified cobalt phthalocyanine (CoPc) carbon electrode (OPG), a known catalyst for reducing O2to H2O2, was used to detect species resulting from the enzyme activity. The electrolyte was a sterilized aqueous medium containing Mueller-Hinton (MH) broth. The open-circuit potential (OCP) of thePseudomonas aeruginosaculture in MH decreased rapidly with time, reaching a stable state after 4 h. Peculiarities in the E / I response were observed in voltammograms conducted in less than 4 h of exposure to the culture medium. Such particular E/I responses are due to the catalase’s enzymatic action related to the conversion of hydrogen peroxide to oxygen, confirming the authors’ previous findings related to the behavior of other catalase-positive microorganisms. The enzymatic activity exhibits maximum activity at pH 7.5, assessed by the potential at which oxygen is reduced to hydrogen peroxide. At higher or lower pHs, the oxygen reduction reaction (ORR) occurs at higher overpotentials, i.e., at more negative potentials. In addition, and to assess the influence of bacterial adhesion on the electrochemical behavior, measurements of the bacterial-substrate metal interaction were performed at different pH using atomic force microscopy.
RETRACTED: Disposable Polymeric Nanostructured Plasmonic Biosensors for Cell Culture Adhesion Monitoring
Authors: Vila Judith Camaló , Castro-Aguirre Nerea , López-Muñoz Gerardo A. , Ferret-Miñana Ainhoa , De Chiara Francesco , Ramón-Azcón Javier 
Published: December 2021

Over the last years, optical biosensors based on plasmonic nanomaterials have gained great scientific interest due to their unquestionable advantages compared to other biosensing technologies. They can achieve sensitive, direct, and label-free analysis with exceptional potential for multiplexing and miniaturization. Recently, it has been demonstrated the potential of using optical discs as high throughput nanotemplates for the development of plasmonic biosensors in a cost-effective way. This work is a pilot study focused on the development of an integrated plasmonic biosensor for the monitoring of cell adhesion and growth of human retinal pigmented cell line (ARPE-19) under different media conditions (0 and 2% of FBS). We observed an increase of the plasmonic band displacement under 2% FBS compared to 0% conditions over time (1, 3, and 5 h). These preliminary results show that the proposed plasmonic biosensing approach is a direct, non-destructive, and real-time tool that could be employed in the study of living cells behavior and culture conditions. Furthermore, this setup could assess the viability of the cells and their growth over time with low variability between the technical replicates improving the experimental replicability.
Transcriptome-wide N6-Methyladenosine Methylome Profiling Reveals m6A Regulation of Skeletal Myoblast Differentiation in Cattle (Bos taurus)
Authors: Yang Xinran , Wang Jianfang , Ma Xinhao , Du Jiawei , Mei Chugang , Zan Linsen 
Published: December 2021

N6-methyladenosine (m6A) is the most prevalent methylation modification of eukaryotic mRNA, and it plays an important role in regulating gene expression. Previous studies have found that m6A methylation plays a role in mammalian skeletal muscle development. However, the effect of m6A on bovine skeletal myogenesis are still unclear. Here, we selected proliferating myoblasts (GM) and differentiated myotubes (on the 4th day of differentiation, DM) for m6A-seq and RNA-seq to explore the m6A methylation modification pattern during bovine skeletal myogenesis. m6A-seq analysis revealed that m6A methylation was an abundant modification of the mRNA in bovine myoblasts and myotubes. We scanned 5,691–8,094 m6A-modified transcripts, including 1,437 differentially methylated genes (DMGs). GO and KEGG analyses revealed that DMGs were primarily involved in transcriptional regulation and RNA metabolism, as well as insulin resistance and metabolic pathways related to muscle development. The combined analysis further identified 268 genes that had significant changes at both m6A and mRNA levels, suggesting that m6A modification may regulate myoblast differentiation by mediating the expression of these genes. Furthermore, we experimentally confirmed four genes related to myogenesis, including MYOZ2, TWIST1, KLF5 and MYOD1, with differential changes in both m6A and mRNA levels during bovine myoblast differentiation, indicating that they can be potential candidate targets for m6A regulation of skeletal myogenesis. Our results may provide new insight into molecular genetics and breeding of beef cattle, and provide a reference for investigating the mechanism of m6A regulating skeletal muscle development.
An Inhibitor of Grp94 Inhibits OxLDL-Induced Autophagy and Apoptosis in VECs and Stabilized Atherosclerotic Plaques
Authors: Wei Qun , Ren Hui , Zhang Jun , Yao Wen , Zhao Baoxiang , Miao Junying 
Published: December 2021

Background: Oxidized low-density lipoprotein (oxLDL) induces vascular endothelial cell (VEC) injury and atherosclerosis through activating endoplasmic reticulum stress. Expression of glucose-regulated protein 94 (Grp94) is induced by endoplasmic reticulum stress and Grp94 is involved in cardiovascular diseases. This study aimed to determine the role of Grp94 in oxLDL-induced vascular endothelial cell injury and atherosclerosis.Methods and Results: An inhibitor of Grp94, HCP1, was used to investigate the role of Grp94 in oxLDL-induced VEC injury in human umbilical vein endothelial cells and atherosclerosis in apolipoprotein E−/− mice. Results showed that HCP1 inhibited autophagy and apoptosis induced by oxLDL in VECs. And we found that Grp94 might interact with adenosine monophosphate-activated protein kinase (AMPK) and activate its activity. HCP1 inhibited AMPK activity and overexpression of Grp94 blocked the effect of HCP1. Besides, HCP1 activated the activity of mechanistic target of rapamycin complex 1 (mTORC1), co-treatment with AMPK activator acadesine eliminated the effect of HCP1 on mTORC1 activity as well as autophagy. In apolipoprotein E−/− mice, HCP1 suppressed autophagy and apoptosis of atherosclerotic plaque endothelium. In addition, HCP1 increased the content of collagen, smooth muscle cells, and anti-inflammatory macrophages while reducing the activity of MMP-2/9 and pro-inflammatory macrophages in the atherosclerotic lesion.Conclusion: HCP1 inhibited oxLDL-induced VEC injury and promoted the stabilization of atherosclerotic plaque in apoE−/− mice. Grp94 might be a potential therapeutic target in the clinical treatment of atherosclerosis.