bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroconvulsive therapy for negative symptoms in schizophrenia: a literature review from 2000 to 2021
Authors: Zierhut Marco M. , Bernard Renaldo M. , Turner Eleanor , Mohamad Sara , Hahn Eric , Bajbouj Malek 
Published: July 2021

AbstractNegative symptoms in schizophrenia remain a clinical challenge with small effect sizes and evidence for pharmacological or psychotherapeutic treatment approaches. Studies suggest that electroconvulsive therapy (ECT) holds some promise as a treatment option of often persistent negative symptoms with clinically meaningful effects. This review summarizes the existing evidence on the efficacy of ECT on negative symptoms in patients with schizophrenia. Thirty-five publications were included in this literature review comprising 21 studies, two meta-analyses, eight reviews and four case reports. Conclusions should be interpreted cautiously, given the small number and methodological shortcomings of the included publications with a variation of study designs and missing standardized protocols. Implications for future research and practice are critically discussed. Recommendations are given to provide more evidence that will meet the clinical challenge of reducing the negative symptoms in schizophrenia. Study designs that focus explicitly on negative symptoms and assess patients over longer follow up periods could be helpful. Future research should include control groups, and possibly establish international multicentered studies to get a sufficient study population. Findings suggest that patients with schizophrenia resistant to pharmacological treatment might benefit from ECT. A risk and benefit assessment speaks in favour of the ECT treatment. Future practice of ECT should include a combination treatment with antipsychotics. Whereas the use of anaesthetics and electrode placement does not seem to play a role, the recommendation regarding frequency of ECT treatments is currently three times a week, For the assessment of negative symptoms the assessment tool should be chosen carefully.
Scraping hide in the early Upper Paleolithic: Insights into the life and function of the Protoaurignacian endscrapers at Fumane Cave
Authors: Aleo Alessandro , Duches Rossella , Falcucci Armando , Rots Veerle , Peresani Marco 
Published: July 2021

AbstractEndscrapers are specialized tools that are usually recovered in great quantities in every Upper Paleolithic site in Europe. Although they make their first ephemeral appearance in the Middle–late Middle Paleolithic transitional technocomplexes, endscrapers commonly appear in toolkits from initial and early Upper Paleolithic traditions onwards. Nevertheless, endscrapers and, in general, domestic tools have attracted relatively little attention in debates revolving around the significance of technological change, tool function, and tool specialization after the end of the Middle Paleolithic. With the aim to overcome this paucity of information, here, we present the results of a techno-functional study performed on the large endscraper assemblage recovered from the early and late Protoaurignacian layers at Fumane Cave in northeastern Italy. We analyzed these artifacts using technological, morpho-metrical, typological, and functional approaches. Despite the large morphological variability, use-wear traces reveal functional consistency and high levels of specialization for these tools. Almost all the use-wear traces we recorded developed from hide working with transverse motion. Moreover, we find no evidence that endscrapers were involved in the production of bone and antler tools during the late Protoaurignacian. Macroscopic and microscopic wear on the lateral edges of tools point to a considerable number of hafted endscrapers, which implies systematic time investment and planning depth. Comparison with the few endscrapers from transitional industries that have been analyzed highlights marked differences in the production, morphology, and use of these tools and reinforces our view of the Aurignacian as a complex not directly related with preceding European traditions.
Keeping pace with the healthcare transformation: a literature review and research agenda for a new decade of health information systems research
Authors: Ostern Nadine , Perscheid Guido , Reelitz Caroline , Moormann Jürgen 
Published: July 2021

Abstract
Background
Accelerated by the coronavirus disease 2019 (Covid-19) pandemic, major and lasting changes are occuring in healthcare structures, impacting people's experiences and value creation in all aspects of their lives. Information systems (IS) research can support analysing and anticipating resulting effects.

Aim
The purpose of this study is to examine in what areas health information systems (HIS) researchers can assess changes in healthcare structures and, thus, be prepared to shape future developments.

Method
A hermeneutic framework is applied to conduct a literature review and to identify the contributions that IS research makes in analysing and advancing the healthcare industry.

Results
We draw an complexity theory by borrowing the concept of 'zooming-in and out', which provides us with a overview of the current, broad body of research in the HIS field. As a result of analysing almost 500 papers, we discovered various shortcomings of current HIS research.

Contribution
We derive future pathways and develop a research agenda that realigns IS research with the transformation of the healthcare industry already under way.
An evidence-based perspective on Lower Urinary Tract Symptoms and telemedicine during the COVID-19 pandemic
Authors: Collins Linda , Khasriya Rajvinder , Malone-Lee James 
Published: July 2021

AbstractThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 pandemic, has had an enormous effect on conventional clinical practice. Telemedicine has emerged as critical to the provision of healthcare services when reducing the transmission of COVID-19 among patients, families, and clinicians. It has been an essential tool for continuing care for patients with lower urinary tract symptoms (LUTS) during the COVID-19 pandemic and has been the link between socially distant patient contact. The aim of this perspective paper was to identify the strengths and limitations of technology-based care focusing on literature linked to patients with lower urinary tract symptoms (LUTS). We search PubMed and CINHAL Plus for grey literature and secondary research on LUTS and telemedicine during the COVID-19 pandemic. Publications dated between the year March 2020 and March 2021were searched. We gathered key specialist opinions in the field of LUTS from several countries around the world, including the countries that had been hit significantly with COVID-19. This perspective paper proposes that there is evidence to support the use of modern technology to facilitate continued healthcare services for patients with LUTS during the COVID-19 pandemic. Telemedicine has been recognised a crucial digital tool for diagnosis, treatment and follow-up appointments during a time of social distancing. Although there are many advantages of telemedicine, the older adult population and those economically disadvantaged with technology may not benefit from technology-based healthcare. The available literature on telemedicine during the COVID-19 pandemic has proven to be successful in the management of some patients with LUTS. It is certain that the COVID-19 pandemic has given telemedicine a significant drive for implementation now and in the immediate future. Robust data on long-term efficacy and safety of telemedicine is required to ensure there are governance protocols embedded when looking after patients with LUTS.
Vortex interaction on a LEX configuration
Authors: Chou Moo-Ting , Miau Jiun-Jih , Chen Li-Yu 
Published: July 2021

AbstractFlow visualization experiments were conducted in a water channel and a low-speed wind tunnel at Reynolds number of 1.54 $$\times$$
×
104 to 1.2 $$\times$$
×
105 for a leading-edge extension model, which is referred to as a NASA TP-1803 model in this study. In addition, particle image velocimetry velocity measurements were taken in the water channel to obtain the quantitative information about the three-dimensional velocity field over the strake and wing surfaces. The results obtained at low, medium and high angles of attacks represent three distinct cases of interaction between the strake and wing vortices. Namely, at α = 5o and 10° the strake and wing vortices were developed over the wing surface without significant interaction noticed; at α = 20°, the strake vortex strongly interacted with the wing vortex in an intertwining manner, which was sensitive to Reynolds number; at α = 30°, the breakdown of the strake vortex took place close to the junction of the strake and the wing; thus, the interaction of the strake and the wing vortices appeared to be less significant than the case of α = 20°.
Graphic abstract
Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer
Authors: Morteza-Semnani Katayoun , Saeedi Majid , Akbari Jafar , Eghbali Mohammad , Babaei Amirhossein , Hashemi Seyyed Mohammad Hassan , Nokhodchi Ali 
Published: July 2021

AbstractEssential oils have been proposed as promising non-toxic transdermal permeation enhancers. Their use is limited because of their low water solubility. The use of nanotechnology-based strategies is one of the ways to overcome this limitation. This study aimed to explore the transdermal permeation enhancing capability of cumin essential oil in nanoemulgel systems containing diclofenac sodium. Cumin essential oil nanoemulsion was produced by high-pressure homogenization technique. The formulation was optimized by changing HLB values in a range of 9.65–16.7 using different surfactant mixtures, namely, Tween 20, Tween 80, and Span 80. Preparations were characterized by polydispersity index, droplet size, and zeta potential. Nanoemulsion with concentrations of 2 and 4% essential oil was incorporated into 0.75% Carbopol gel matrix to make nanoemulgel formulation, and its permeation enhancing effect was performed through Franz diffusion cells. Antinociceptive activities of the formulations were measured in thermal (tail-flick) and chemical (formalin) models of nociception in mice. Characterization exhibited that at HLB value of 9.65, the smallest particle size (82.20 ± 5.82 nm) was formed. By increasing the essential oil percentage in the nanoemulgel from 1 to 2%, the permeation of diclofenac increased from 28.39 ± 1.23 to 34.75 ± 1.07 µg/cm2 at 24 h. The value of permeation from the simple gel (21.18 ± 2.51 µg/cm2) and the marketed product (22.97 ± 1.92 µg/cm2) was lower than the formulations containing essential oil. Nanoemulgel of diclofenac containing essential oil showed stronger antinociceptive effects in formalin and tail-flick tests than simple diclofenac gel and marketed formulation. In conclusion, the study proved that nanoemulgel formulation containing cumin essential oil could be considered as a promising skin enhancer to enhance the therapeutic effect of drugs.
Graphical abstract
Laplace Contour Integrals and Linear Differential Equations
Authors: Steinmetz Norbert 
Published: July 2021

AbstractThe purpose of this paper is to determine the main properties of Laplace contour integrals$$\begin{aligned} \Lambda (z)=\frac{1}{2\pi i}\int _\mathfrak {C}\phi (t)e^{-zt}\,dt \end{aligned}$$Λ(z)=12πi∫Cϕ(t)e-ztdtthat solve linear differential equations$$\begin{aligned} L[w](z):=w^{(n)}+\sum _{j=0}^{n-1}(a_j+b_jz)w^{(j)}=0. \end{aligned}$$L[w](z):=w(n)+∑j=0n-1(aj+bjz)w(j)=0.This concerns, in particular, the order of growth, asymptotic expansions, the Phragmén–Lindelöf indicator, the distribution of zeros, the existence of sub-normal and polynomial solutions, and the corresponding Nevanlinna functions.
Children with Autism Spectrum Disorder Spent 30 Min Less Daily Time in Moderate-to-Vigorous Physical Activity than Typically Developing Peers: a Meta-Analysis of Cross-sectional Data
Authors: Rostami Haji Abadi Mahdi , Zheng Yuwen , Wharton Tiffany , Dell Colleen , Vatanparast Hassanali , Johnston James , Kontulainen Saija 
Published: July 2021

AbstractIt remains unclear if participation in moderate-to-vigorous physical activity (MVPA) differs between children with ASD and typically developing children (TDC). We compared daily MVPA, time spent in MVPA during physical education (PE) and recess, and odds of not meeting MVPA recommendation (60 min/day) between children with ASD and TDC. Nine studies reporting accelerometer-measured MVPA were included in the meta-analyses. MVPA was 30 min lower/day, 12% and 8% lower during PE and recess, respectively, in children with ASD, and they had 4 times higher odds of not meeting MVPA recommendation when compared to TDC. Children with ASD engage in daily MVPA less than TDC and below the guidelines. Tailored interventions to increase MVPA in children with ASD are warranted.
A neutrosophic set-based TLBO algorithm for the flexible job-shop scheduling problem with routing flexibility and uncertain processing times
Authors: Jin Liangliang , Zhang Chaoyong , Wen Xiaoyu , Sun Chengda , Fei Xinjiang 
Published: July 2021

AbstractDifferent with the plain flexible job-shop scheduling problem (FJSP), the FJSP with routing flexibility is more complex and it can be deemed as the integrated process planning and (job shop) scheduling (IPPS) problem, where the process planning and the job shop scheduling two important functions are considered as a whole and optimized simultaneously to utilize the flexibility in a flexible manufacturing system. Although, many novel meta-heuristics have been introduced to address this problem and corresponding fruitful results have been observed; the dilemma in real-life applications of resultant scheduling schemes stems from the uncertainty or the nondeterminacy in processing times, since the uncertainty in processing times will disturb the predefined scheduling scheme by influencing unfinished operations. As a result, the performance of the manufacturing system will also be deteriorated. Nevertheless, research on such issue has seldom been considered before. This research focuses on the modeling and optimization method of the IPPS problem with uncertain processing times. The neutrosophic set is first introduced to model uncertain processing times. Due to the complexity in the math model, we developed an improved teaching-learning-based optimization(TLBO) algorithm to capture more robust scheduling schemes. In the proposed optimization method, the score values of the uncertain completion times on each machine are compared and optimized to obtain the most promising solution. Distinct levels of fluctuations or uncertainties on processing times are defined in testing the well-known Kim’s benchmark instances. The performance of computational results is analyzed and competitive solutions with smaller score values are obtained. Computational results show that more robust scheduling schemes with corresponding neutrosophic Gantt charts can be obtained; in general, the results of the improved TLBO algorithm suggested in this research are better than those of other algorithms with smaller score function values. The proposed method in this research gives ideas or clues for scheduling problems with uncertain processing times.
Healthcare Sustainability Evaluation Using a Hybrid Fuzzy Multi-Criteria Decision-Making Model
Authors: Erjaee Asma , Hendiani Sepehr , Moradi Shohreh , Bagherpour Morteza 
Published: July 2021

AbstractDeveloping a sustainable healthcare system directly depends on the level of maturity in environmental, social, and economic practices. Although there are huge number of researches considering environmental, social, and economic aspects, to the best of our knowledge, no approach was found which unifies these dimensions as an integrated method to assess the current status of sustainable development in healthcare organizations. In order to cope with this gap, this article suggests a method for analyzing the sustainability indicator in healthcare systems by manipulating the sustainability dimensions, criteria, and attributes. The following research has collected 62 attributes and 15 criteria for three sustainability dimensions. A new implementation method is also proposed to make this approach applicable in real-world problems. The contributions of this paper can be distinguished as the healthcare system’s sustainability level in imprecise conditions is obtained, the capability of identifying the weak points in implementing sustainability aspects is presented, and a new methodology for collecting the fundamental data for measuring the sustainability level in healthcare systems is given. The findings of this paper assist the practitioners and experts to successfully evaluate the sustainability level of healthcare systems and significantly improve the performance of them.
The remaining CO2 budget: a comparison of the CO2 emissions of diesel and BEV drivetrain technology
Authors: Böhmeke Christian , Koch Thomas 
Published: July 2021

AbstractThis paper describes the CO2 emissions of the additional electricity generation needed in Germany for battery electric vehicles. Different scenarios drawn up by the transmission system operators in past and for future years for expansion of the energy sources of electricity generation in Germany are considered. From these expansion scenarios, hourly resolved real-time simulations of the different years are created. Based on the calculations, it can be shown that even in 2035, the carbon footprint of a battery electric vehicle at a consumption of 22.5 kWh/100 km including losses and provision will be around 100 g CO2/km. Furthermore, it is shown why the often-mentioned German energy mix is not suitable for calculating the emissions of a battery electric vehicle fleet. Since the carbon footprint of a BEV improves significantly over the years due to the progressive expansion of renewable-energy sources, a comparison is drawn at the end of this work between a BEV (29.8 tons of CO2), a conventional diesel vehicle (34.4 tons of CO2), and a diesel vehicle with R33 fuel (25.8 tons of CO2) over the entire useful life.
Citywide quality of health information system through text mining of electronic health records
Authors: Funkner Anastasia A. , Egorov Michil P. , Fokin Sergey A. , Orlov Gennady M. , Kovalchuk Sergey V. 
Published: July 2021

AbstractA system of hospitals in large cities can be considered a large and diverse but interconnected system. Widely applied in hospitals, electronic health records (EHR) are crucially different from each other because of the use of different health information systems, internal hospital rules, and individual behavior of physicians. The unstructured (textual) data of EHR is rarely used to assess the citywide quality of healthcare. Within the study, we analyze EHR data, particularly textual unstructured data, as a reflection of the complex multi-agent system of healthcare in the city of Saint Petersburg, Russia. Through analyzing the data collected by the Medical Information and Analytical Center, a method was proposed and evaluated for identifying a common structure, understanding the diversity, and assessing information quality in EHR data through the application of natural language processing techniques.
Hi–C interaction graph analysis reveals the impact of histone modifications in chromatin shape
Authors: Sefer Emre 
Published: July 2021

AbstractChromosome conformation capture experiments such as Hi–C map the three-dimensional spatial organization of genomes in a genome-wide scale. Even though Hi–C interactions are not biased towards any of the histone modifications, previous analysis has revealed denser interactions around many histone modifications. Nevertheless, simultaneous effects of these modifications in Hi–C interaction graph have not been fully characterized yet, limiting our understanding of genome shape. Here, we propose ChromatinCoverage and its extension TemporalPrizeCoverage methods to decompose Hi–C interaction graph in terms of known histone modifications. Both methods are based on set multicover with pairs, where each Hi–C interaction is tried to be covered by histone modification pairs. We find 4 histone modifications H3K4me1, H3K4me3, H3K9me3, H3K27ac to be significantly predictive of most Hi–C interactions across species, cell types and cell cycles. The proposed methods are quite effective in predicting Hi–C interactions and topologically-associated domains in one species, given it is trained on another species or cell types. Overall, our findings reveal the impact of subset of histone modifications in chromatin shape via Hi–C interaction graph.
TemporalRI: subgraph isomorphism in temporal networks with multiple contacts
Authors: Micale Giovanni , Locicero Giorgio , Pulvirenti Alfredo , Ferro Alfredo 
Published: July 2021

AbstractTemporal networks are graphs where each edge is associated with a timestamp denoting when two nodes interact. Temporal Subgraph Isomorphism (TSI) aims at retrieving all the subgraphs of a temporal network (called target) matching a smaller temporal network (called query), such that matched target edges appear in the same chronological order of corresponding query edges. Few algorithms have been proposed to solve the TSI problem (or variants of it) and most of them are applicable only to small or specific queries. In this paper we present TemporalRI, a new subgraph isomorphism algorithm for temporal networks with multiple contacts between nodes, which is inspired by RI algorithm. TemporalRI introduces the notion of temporal flows and uses them to filter the search space of candidate nodes for the matching. Our algorithm can handle queries of any size and any topology. Experiments on real networks of different sizes show that TemporalRI is very efficient compared to the state-of-the-art, especially for large queries and targets.
A measure of local uniqueness to identify linchpins in a social network with node attributes
Authors: Nemesure Matthew D. , Schwedhelm Thomas M. , Sacerdote Sofia , O’Malley A. James , Rozema Luke R. , Moen Erika L. 
Published: July 2021

AbstractNetwork centrality measures assign importance to influential or key nodes in a network based on the topological structure of the underlying adjacency matrix. In this work, we define the importance of a node in a network as being dependent on whether it is the only one of its kind among its neighbors’ ties. We introduce linchpin score, a measure of local uniqueness used to identify important nodes by assessing both network structure and a node attribute. We explore linchpin score by attribute type and examine relationships between linchpin score and other established network centrality measures (degree, betweenness, closeness, and eigenvector centrality). To assess the utility of this measure in a real-world application, we measured the linchpin score of physicians in patient-sharing networks to identify and characterize important physicians based on being locally unique for their specialty. We hypothesized that linchpin score would identify indispensable physicians who would not be easily replaced by another physician of their specialty type if they were to be removed from the network. We explored differences in rural and urban physicians by linchpin score compared with other network centrality measures in patient-sharing networks representing the 306 hospital referral regions in the United States. We show that linchpin score is uniquely able to make the distinction that rural specialists, but not rural general practitioners, are indispensable for rural patient care. Linchpin score reveals a novel aspect of network importance that can provide important insight into the vulnerability of health care provider networks. More broadly, applications of linchpin score may be relevant for the analysis of social networks where interdisciplinary collaboration is important.