bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring entrepreneurial culture and its socio-cultural determinants: in case of Woldia University graduating students
Authors: Ebabu Engidaw Abriham 
Published: April 2021

AbstractThe purpose of this study was to explore entrepreneurial intention and its determinants: in the case of Woldia University graduating students. To achieve its objectives, the study employed a descriptive and explanatory research design, and in the study, a cross-sectional study was conducted through a mixed research approach. The target population of the study was 223 regular first-degree 2018 graduating students of Woldia University, Management Department, and their instructors in the study area. The sample size was 143 respondents. The study result showed that majority of the respondents did not plan to start their own knowledge-based business. This was essentially due to the lack of competence in transforming ideas in to practice and commercializing it to create their own business. Correspondingly, prodigious attention should be given to have an entrepreneurial orientation in the contents and methods of teaching at all levels of education systems primary, secondary, and higher educational institutions and use different awareness-raising mechanisms in the country.
When your host shuts down: larval diapause impacts host-microbiome interactions in Nasonia vitripennis
Authors: Dittmer Jessica , Brucker Robert M. 
Published: April 2021

AbstractBackgroundThe life cycles of many insect species include an obligatory or facultative diapause stage with arrested development and low metabolic activity as an overwintering strategy. Diapause is characterised by profound physiological changes in endocrine activity, cell proliferation and nutrient metabolism. However, little is known regarding host-microbiome interactions during diapause, despite the importance of bacterial symbionts for host nutrition and development. In this work, we investigated (i) the role of the microbiome for host nutrient allocation during diapause and (ii) the impact of larval diapause on microbiome dynamics in the parasitoid waspNasonia vitripennis, a model organism for host-microbiome interactions.ResultsOur results demonstrate that the microbiome is essential for host nutrient allocation during diapause inN. vitripennis, as axenic diapausing larvae had consistently lower glucose and glycerol levels than conventional diapausing larvae, especially when exposed to cold temperature. In turn, microbiome composition was altered in diapausing larvae, potentially due to changes in the surrounding temperature, host nutrient levels and a downregulation of host immune genes. Importantly, prolonged larval diapause had a transstadial effect on the adult microbiome, with unknown consequences for host fitness. Notably, the most dominant microbiome member,Providenciasp., was drastically reduced in adults after more than 4 months of larval diapause, while potential bacterial pathogens increased in abundance.ConclusionThis work investigates host-microbiome interactions during a crucial developmental stage, which challenges both the insect host and its microbial associates. The impact of diapause on the microbiome is likely due to several factors, including altered host regulatory mechanisms and changes in the host environment.
Evaluating receiver contributions to acoustic positional telemetry: a case study on Atlantic cod around wind turbines in the North Sea
Authors: van der Knaap Inge , Slabbekoorn Hans , Winter Hendrik V. , Moens Tom , Reubens Jan 
Published: April 2021

Abstract
Background
The effect of individual acoustic receiver contributions to animal positioning is a crucial aspect for the correct interpretation of acoustic positional telemetry (APT). Here, we evaluated the contribution of each receiver within two APT designs to the number of tag signals detected and the position accuracy of free-ranging Atlantic cod, through data exclusion of single receivers from the analysis. The two APTs were deployed around offshore (ca 50 km) wind turbines at which 27 individual cod were tagged.

Results
We found that the exclusion of data from an APT receiver that was positioned within the movement area of the individual fish reduced the number of tag signals detected and the position accuracy of the set-up the most. Excluding the data from a single receiver caused a maximum of 34% positions lost per fish and a maximum increase in core area of 97.8%. Single-receiver data exclusion also caused a potentially large bias in the reconstruction of swimming tracks. By contrast, exclusion of a receiver that was deployed within 50 m from a turbine actually improved fish position accuracy, probably because the turbine can cause signal interference as a reflective barrier.

Conclusions
We recommend that an exploratory small-scale study like the one presented here be conducted before embarking on a larger-scale APT study. By excluding the data of single receivers from the positioning analysis, we were able to explore the suitability of a receiver set-up for the movement patterns of our target species. Furthermore, when a receiver is lost from an APT during deployment, the data should be treated with care as our results show that changes in triangulation outcome can lead to considerable differences in swimming tracks and home range estimates.
An analysis of the graph processing landscape
Authors: Coimbra Miguel E. , Francisco Alexandre P. , Veiga Luís 
Published: April 2021

AbstractThe value of graph-based big data can be unlocked by exploring the topology and metrics of the networks they represent, and the computational approaches to this exploration take on many forms. For the use-case of performing global computations over a graph, it is first ingested into a graph processing system from one of many digital representations. Extracting information from graphs involves processing all their elements globally, which can be done with single-machine systems (with varying approaches to hardware usage), distributed systems (either homogeneous or heterogeneous groups of machines) and systems dedicated to high-performance computing (HPC). For these systems focused on processing the bulk of graph elements, common use-cases consist in executing for example algorithms for vertex ranking or community detection, which produce insights on graph structure and relevance of their elements. Many distributed systems (such as , ) and libraries (e.g. , ) have been built to enable these tasks and improve performance. This is achieved with techniques ranging from classic load balancing (often geared to reduce communication overhead) to exploring trade-offs between delaying computation and relaxing accuracy. In this survey we firstly familiarize the reader with common graph datasets and applications in the world of today. We provide an overview of different aspects of the graph processing landscape and describe classes of systems based on a set of dimensions we describe. The dimensions we detail encompass paradigms to express graph processing, different types of systems to use, coordination and communication models in distributed graph processing, partitioning techniques and different definitions related to the potential for a graph to be updated. This survey is aimed at both the experienced software engineer or researcher as well as the graduate student looking for an understanding of the landscape of solutions (and their limitations) for graph processing.
Successful laparoscopy-assisted repair of a rectovaginal fistula after low anterior resection for rectal cancer: a report of two cases
Authors: Ohta Hiroyuki , Hashimoto Kyozo , Mizukuro Tomoyuki , An Byonggu , Zen Yumi , Nishina Yusuke , Terada Yoshitaka , Kitamura Naomi , Akabori Hiroya , Fujino Mitsuhiro , Mekata Eiji 
Published: April 2021

Abstract
Background
Rectovaginal fistula (RVF) after low anterior resection for rectal cancer is troublesome and refractory. Although various surgical procedures have been previously described, no definitive procedure has shown a satisfactory outcome. We present two consecutive Japanese patients who underwent successful surgery for an RVF after low anterior resection.

Case presentation
The patients were two women (61-year-old and a 64-year-old). They were admitted to our hospital with a chief complaint of fecal discharge from the vagina after low anterior resection using the double-stapling technique for rectal cancer. They were diagnosed with RVF. Local surgical procedures, including diverting ileostomy, were unsuccessful in previous hospitals. Therefore, we performed laparoscopy-assisted repair of the RVF. In both patients, laparoscopically robust pelvic adhesions were dissected, and the sigmoid colon was transected at just oral side to the RVF. Thereafter, in combination with a perineal approach, the rectum, along with a previous anastomosis and fistula, were completely removed. Surgeries were completed after vaginal repair, redo coloanal anastomosis, and interposition of the dissected connective tissue. In both patients, the postoperative courses were uneventful. They complained of neither recurrence of any RVF nor fecal incontinence 1 year and 10 months after diverting stoma closure.

Conclusions
A laparoscopy-assisted procedure with reanastomosis and interposition of the perineal connective tissue can be an effective treatment for RVF after low anterior resection for rectal cancer.
Association Between Short-, Intermediate-, and Long-term Mortality and Myocardial Injury After Noncardiac Surgery After Hip Fracture Surgery: A Retrospective Cohort
Authors: Vacheron Charles-Hervé , Hentzen Julie , Fauvernier Mathieu , Fessy Michel , Chaudier Philippe , Landel Verena , David Jean Stephane , Incagnoli Pascal , Piriou Vincent , Friggeri Arnaud 
Published: April 2021

BACKGROUND:
For more than 20 years, hip fracture 1-year mortality has remained around 20%. An elevation of the postoperative troponin peak within 72 hours (myocardial injury after noncardiac surgery [MINS]) is associated with a greater risk of short-term mortality in the general population. However, there seem to be conflicting results in the specific population who undergo hip fracture surgery, with some studies finding an association between troponin and mortality and some not. The objective of the present study was to investigate the association of MINS and the short- (before 28th day), intermediate- (before 180th day), and long-term (before 365th day) mortality after hip fracture surgery.

METHODS:
We conducted a single-center retrospective cohort of patients undergoing hip fracture surgery from November 2013 to December 2015. MINS was defined as postoperative troponin peak within the 72 hours >5 ng/L. Four MINS subgroups were defined according to the value of troponin peak (ie, ≥5–<20, ≥20–<65, ≥65–<1000, and ≥1000 ng/L). To document the association between the different mortality terms and the troponin peak, odds ratio (OR) and adjusted OR (aOR) associated with their 95% confidence interval (CI) with the log of the scaled troponin peak within 72 hours were estimated, with and without patients presenting a postoperative acute coronary syndrome (ACS). Cox proportional hazards modeling was used to estimate hazard ratio (HR) and adjusted HR (aHR) of death between the no MINS and MINS subgroups. The adjustment was performed on the main confounding factors (ie, sex, American Society of Anesthesiologists [ASA] physical status, dementia status, age, and time from admission to surgery).

RESULTS:
Among 729 participants, the mean age was 83.1 (standard deviation [SD] = 10.8) years, and 77.4% were women; 30 patients presented an ACS (4%). Short-, intermediate-, and long-term mortality were at 5%, 16%, and 23%, respectively. The troponin peak was significantly associated with all terms of mortality before and after adjustment and before and after exclusion of patients presenting an ACS. HR and aHR for each subgroup of troponin level were significantly associated with an increased probability of survival, except for the 5 to 20 ng/L group for which aHR was not significant (1.75, 95% CI, 0.82-3.74). In the landmark analysis, there was still an association between survival at the 365th day and troponin peak after the short- and intermediate-term truncated mortality.

CONCLUSIONS:
MINS is associated with short-, intermediate-, and long-term mortality after hip fracture surgery. This could be a valuable indicator to determine the population at high risk of mortality that could benefit from targeted prevention and possible intervention.
Appetite and Energy Intake Regulation in Response to Acute Exercise
Authors: HALLIDAY TANYA M. , WHITE MOLLIE H. , HILD ALLISON K. , CONROY MOLLY B. , MELANSON EDWARD L. , CORNIER MARC-ANDRE 
Published: April 2021

ABSTRACT

Purpose
This study aimed to determine if energy intake and appetite regulation differ in response to an acute bout of resistance exercise (REx) versus aerobic exercise (AEx).

Methods
Physically inactive adults (n = 24, 35% ± 2% body fat, 50% female) completed three conditions: AEx (walking at 65%–70% heart rate max for 45 min), REx (1 set to failure of 12 exercises), and sedentary control (SED). Each condition was initiated in the postprandial state (35 min after breakfast). Appetite (visual analog scale for hunger, satiety, and prospective food consumption) and hormones (ghrelin, peptide YY (PYY), and glucagon-like peptide-1 (GLP-1)) were measured before and 30, 90, 120, 150, and 180 min after a standardized breakfast. Area under the curve was calculated using the trapezoid method. Ad libitum energy intake was evaluated at a lunch meal after the 180-min measurements.

Results
No differences in ad libitum energy intake (REx, 991 ± 68; AEx, 937 ± 65; SED, 944 ± 76 kcal; P = 0.50) or appetite ratings (all, P > 0.05) were detected. The area under the curve for ghrelin, PYY, and GLP-1 were all lower after REx versus AEx (ghrelin: 130,737 ± 4928 for REx; 143,708 ± 7500 for AEx (P = 0.006); PYY: 20,540 ± 1177 for REx, 23,812 ± 1592 for AEx (P = 0.001); and GLP-1: 1314 ± 93 for REx, 1615 ± 110 for AEx (P = 0.013)). Neither exercise condition significantly differed from SED.

Conclusions
Acute REx lowers both orexigenic (ghrelin) and anorectic (PYY and GLP-1) gut peptides compared with acute AEx. Ad libitum energy intake did not increase compared with SED in either exercise condition, indicating both exercise modalities have appetite and energy intake suppressing effects. Future work is needed to determine if exercise of differing modalities influences chronic appetite regulation.
Are computed-tomography-based hematoma radiomics features reproducible and predictive of intracerebral hemorrhage expansion? an in vitro experiment and clinical study
Authors: Chen Kai , Deng Lijing , Li Qing , Luo Liangping 
Published: April 2021

Objectives:
To identify reproducible hematoma radiomics features (RFs) for use in predicting hematoma expansion (HE) in patients with acute intracerebral hemorrhage (ICH).

Methods:
For test–retest analysis, three syringes with different volumes of blood collected at the same time (to mimic homogeneous hematoma) and a phantom (FT/HK 2000; Huake, Szechwan, China) containing three cylindrical inserts were scanned seven times within 6 h on the same CT scanner. Three additional syringes with mixed blood collected at different time points (to mimic heterogeneous hematoma) were tied together with the first three syringes as well as the phantom were scanned using modified CT acquisition parameters for intra CT analysis. A coefficient of variation below 10% served as the cutoff value for reproducibility. Finally, reproducible and potentially useful RFs were used to predict HE in 144 acute ICH patients, with the area under the receiver operating characteristic curves (AUC) used to evaluate their diagnostic performance.

Results:
A total of 630 RFs including 18 first-order, 24 gray-level co-occurrence matrix (GLCM), 16 gray-level run length matrix (GLRLM), five neighborhood gray-tone difference matrix (NGTDM), 63 Laplacian of Gaussian (LoG), and 504 Wavelet features were evaluated. In the test-retest analysis, the percentages of reproducible RFs ranged from 42.54% (268/630) to 45.4% (286/630) for the three homogeneous hematoma samples and 79.05% (498/630) to 81.43% (513/630) for the phantom. In the intra-CT analysis, the percentages varied from 31.43% (198/630) to 42.38% (267/630) for the six hematoma samples and 48.89% (308/630) to 53.97% (340/630) for the phantom. In the in vitro experiment, 148 RFs were reproducible for all hematoma samples in both the test-retest and intra-CT analyses; however, only 80 were statistically different between homogeneous and heterogeneous hematoma samples. Finally, HE occurred in 25% (growth &gt;6 ml, 36/144) to 31.94% (growth &gt;3 ml or 33%, 46/144) of the patients. The AUCs in predicting HE ranged from 0.625 to 0.703.

Conclusions:
Only a few CT-based RFs from the in vitro hematoma were reproducible and can distinguish between homogeneous and heterogeneous hematomas. The use of RFs alone to predict HE in acute ICH showed only a moderate performance.

Advances in knowledge:
Using an in vitro experiment and clinical validation, this study demonstrated for the first time that CT-based hematoma RFs can be used to predict HE in acute ICH; nonetheless, only a few RFs are reproducible and can be used for prediction.
Inter-site and interpersonal diversity of salivary and tongue microbiomes, and the effect of oral care tablets
Authors: Maruyama Hugo , Masago Ayako , Nambu Takayuki , Mashimo Chiho , Takahashi Kazuya , Okinaga Toshinori 
Published: April 2021

Background: Oral microbiota has been linked to both health and diseases. Specifically, tongue-coating microbiota has been implicated in aspiration pneumonia and halitosis. Approaches altering one's oral microbiota have the potential to improve oral health and prevent diseases. Methods: Here, we designed a study that allows simultaneous monitoring of the salivary and tongue microbiomes during an intervention on the oral microbiota. We applied this study design to evaluate the effect of single-day use of oral care tablets on the oral microbiome of 10 healthy individuals. Tablets with or without actinidin, a protease that reduces biofilm formation in vitro, were tested. Results: Alpha diversity of the tongue microbiome was significantly lower than that of the salivary microbiome, using both the number of observed amplicon sequence variants (254 ± 53 in saliva and 175 ± 37 in tongue; P = 8.9e-7, Kruskal–Wallis test) and Shannon index (6.0 ± 0.4 in saliva and 5.4 ± 0.3 in tongue; P = 2.0e-7, Kruskal–Wallis test). Fusobacterium periodonticum, Saccharibacteria sp. 352, Streptococcus oralis subsp. dentisani, Prevotella melaninogenica, Granulicatella adiacens, Campylobacter concisus, and Haemophilus parainfluenzae were the core operational taxonomic units (OTUs) common to both sites. The salivary and tongue microbiomes of one individual tended to be more similar to one another than to those of other individuals. The tablets did not affect the alpha or beta diversity of the oral microbiome, nor the abundance of specific bacterial species. Conclusions: While the salivary and tongue microbiomes differed significantly in terms of bacterial composition, they showed inter- rather than intra-individual diversity. A one-day usage of oral care tablets did not alter the salivary or tongue microbiomes of healthy adults. Whether the use of oral tablets for a longer period on healthy people or people with greater tongue coating accumulation shifts their oral microbiome needs to be investigated.
Influence of Proton Pump Inhibitors and Histamine Receptor 2 Antagonists on Blastocystis ST3 and Selected Microorganisms of Intestinal Microbiota In Vitro
Authors: Lepczyńska Małgorzata , Dzika Ewa , Chen WenChieh , Lu Chien-Yu 
Published: April 2021

INTRODUCTION:
Proton pump inhibitors (PPIs) and histamine receptor 2 (H2) antagonists are commonly prescribed medications. Association between PPIs and alteration of the gut microbiota has been reported. Blastocystis, the most common intestinal protozoan worldwide, occurs in both healthy and symptomatic people with gastrointestinal or cutaneous disorders, with controversial pathogenicity. The current study was aimed to investigate the influence of PPIs and H2 blockers on the in vitro proliferation of selected intestinal bacteria, fungi, and protozoa.

METHODS:
Cultures of Lactobacillus rhamnosus, Escherichia coli, Enterococcus faecium, Candida albicans, and Blastocystis subtype 3 were treated with different concentrations of respective medications in vitro, and the numbers of microorganisms were quantified and compared.

RESULTS:
Pantoprazole and esomeprazole exerted a significant inhibition on Blastocystis and C. albicans, especially at higher concentrations, which were even more effective than metronidazole. On the other hand, treatment with pantoprazole caused an increase in proliferation of L. rhamnosus and E. coli. There was no influence of H2 blockers on the examined microorganisms.

DISCUSSION:
PPIs, such as pantoprazole, can be a potential treatment in the prophylaxis or eradication of Blastocystis and C. albicans.
Many Paradoxes of My Gastroenterology Practice
Authors: Sonnenberg Amnon 
Published: April 2021

Abstract
A paradox describes the clash between 2 seemingly reasonable prepositions whose joint occurrence appears impossible. Like any other human endeavor, medicine is also filled with paradoxes that await resolution. This editorial lists several common paradoxes frequently encountered by clinical gastroenterologists. These examples illustrate the interplay between risk and benefit, cost and effect, disease and cure, and escape and exposure. It is hoped that addressing these paradoxes and trying to resolve their underlying contradictions will ultimately lead to a more efficacious and rational delivery of healthcare.
TRAJECTORIES OF DISSOCIATIVE EXPERIENCES IN ADOLESCENT FEMALES EXPOSED TO CHILD MALTREATMENT: INFLUENCE OF FRONTAL EEG ASYMMETRY
Authors: Hassan Raha , Macmillan Harriet L. , Schmidt Louis A. 
Published: April 2021

Introduction: Dissociative experiences resulting in disruptions in the integration of an organized sense of self are one consequence of childhood maltreatment, and is associated with psychopathology and maladjustment across development. Despite the consequences of dissociative experiences, we know relatively little about the physiological factors associated with the development of dissociative experiences in children exposed to maltreatment.Methods: Using a 3-wave short-term prospective design, we examined the influence of resting frontal alpha asymmetry at rest on the trajectory of dissociative experiences in a sample of adolescents exposed to documented child maltreatment (N = 55; Mage= 15.93, SDage= 1.02).Results: Adolescents with greater relative left frontal alpha asymmetry at rest exhibited increasing trajectories of dissociative experiences over one year.Discussion: Our results are discussed in the context physiological indexes of emotion dysregulation associated with dissociative experiences in youth exposed to child maltreatment.