bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in the Petrophysical and Dynamic Characterization of Deepwater Turbidite Deposits of the Colombian Caribbean Offshore–A Case Study
Authors:   ECOPETROL S.A., Angel Restrepo Juan Alejandro , Gómez-Moncada Ricardo Andrés ,   ECOPETROL S.A., Mora Sánchez Carlos Alberto ,   ECOPETROL S.A., Bueno Silva Ricardo ,   ECOPETROL S.A.
Published: March 2021

The Colombian Caribbean region has become an important exploratory target, and recent discoveries confirm its potential as a gas province to overcome the expected near-future gas deficit.	A petrophysical and dynamic characterization workflow was implemented for this challenging deepwater play, where the depositional environment is the result of turbidity current processes. The reservoirs consist mostly of thin to very thin sand layers, corresponding mainly to the Ta, Tb, and Tc divisions of the Bouma sequence as observed in the cored intervals. Bouma divisions Td and Te are related with the lowest rock quality and represent the nonreservoir intervals.	The greatest challenge in the characterization of this particular reservoir is the vertical resolution, given the very low thickness of the layers, which becomes very difficult to detect using standard resolution logs. Thus, tomography images, resultant CT-scan curves, and their integration with routine and special core analyses were used to reveal the true nature of this complex reservoir.	The proposed methodology focuses on the integration of routine and special core analysis for the petrophysical and dynamic characterization of the reservoir, where the pore-throat-radius distribution from high-pressure mercury injection becomes the basis of the differentiation between what is considered reservoir and what is not. Pore-throat radius estimated from high-pressure mercury injection (R35) correlates extremely well with textural features and clay content in the rock; therefore, this parameter (R35) was used to define the different classes for rock typing. The approach taken was to develop a multilinear regression model of R35 as a function of very high-resolution tomography outputs in the cored zones and then see how it may be extrapolated to the uncored zones using available high-resolution logs.	Special petrophysical analyses, such as NMR low field, porous-plate capillary pressure, electrical properties, and relative permeability curves (steady state), showed correlation with the defined rock types and, in turn, allowed for a determination of the gas accumulation potential of the area.	Finally, rock and fluid (dry-gas) properties have been used to build a single-well radial model to design initial well tests (DST) and predict production performance from each interval (selective tests). The simulation model represents the lateral and vertical heterogeneity related to the geological environment (turbidites). The final results have defined the flow and shut-in times during tests to optimize the budget.
An Integrated Petrophysical Workflow for Fluid Characterization and Contacts Identification Using NMR Continuous and Stationary Measurements in a High-Porosity Sandstone Formation, Offshore Norway
Authors:   Halliburton, Kozlowski Maciej , Chakraborty Diptaroop ,   Halliburton, Jambunathan Venkat ,   Halliburton, Lowrey Peyton ,   Halliburton, Balliet Ron ,   Halliburton, Engelman Bob ,   Halliburton, Ånensen Katrine Ropstad ,   Aker BP, Kotwicki Artur ,   Aker BP, Johansen Yngve Bolstad ,   Aker BP
Published: March 2021

The Alvheim Field in the Norwegian North Sea was discovered in 1998. Two wells were drilled in 2018 in the Gekko structure to confirm oil column height and to evaluate reservoir quality in the Heimdal Formation. A comprehensive wireline logging program, including NMR and formation testing, was optimized to reduce formation evaluation uncertainty. Evaluating fluid properties, oil column height, and reservoir quality were primary objectives. Well A was first drilled on the south of the structure, followed by Well B on the north of the structure. Reservoir quality encountered in both wells was very good, and a project to develop these resources is currently in the selection phase.	Formation evaluation uncertainty encompassing pore geometry distribution, permeability, reservoir quality, and hydrocarbon identification are mitigated by studying the nuclear magnetic resonance (NMR) log response. NMR fluid typing has been widely used in the oil industry since the 1990s. NMR fluid typing today is a combination of the contrast of spin relaxation time T1, the spin-spin relaxation time T2 (T1T2), and the diffusivity (T2D) of formation fluids (Chen et al., 2016). NMR fluid typing can be obtained from a continuous log and/or stationary log measurements.	This paper showcases excellent, textbook-quality NMR data, as well as the integration of NMR data in the petrophysical workflow. High-confidence fluid properties and fluid contacts are determined.	This paper also highlights a comparison of NMR data acquired in stationary vs. continuous depth-based log modes in both wells. The continuous log data quality is equivalent to stationary data, implying continuous log data quality is sufficient for reliable NMR fluid properties evaluation without depending on time-consuming stationary NMR measurements. Reducing logging operations rig time is very advantageous in the North Sea, where drilling rig operations cost is high, and enhanced rig time management is constantly required.
Jordi Castellví Mata (2019). Literacidad crítica digital en los estudios sociales. Estudios de caso en educación primaria
Authors: González Milea Arasy 
Published: March 2021

La tesis titulada “Literacidad Crítica Digital. Estudios de caso en Educación Primaria” ha sido dirigida por el Dr. Antoni Santisteban Fernández, y defendida el 2 de diciembre de 2019 en la Facultad de Ciencias de la Educación de la Universidad Autónoma de Barcelona.
El tribunal de evaluación estuvo constituido por el Dr. Joan Pagès Blanch (Presidente), Dra. Montserrat Yuste Munté (Vocal), y la Dra. Edda Sant Obiols (Secretaria).
УПРАВЛІННЯ ІННОВАЦІЙНИМИ БІЗНЕС-ПРОЦЕСАМИ АГРАРНИХ ПІДПРИЄМСТВ СІЛЬСЬКИХ РЕГІОНІВ
Authors: Nifatova Olena M. 
Published: March 2021

The article seeks to provide a robust framework to ensure effective management of innovative business processes at agricultural companies in rural areas. Based on different conceptual interpretations of the "innovation" and "business processes" terms, this study suggests to consider the innovative business processes as a goal-oriented set of operations (activities) performed sequentially or simultaneously (transforming inputs into outputs) that shapes a desired ultimate result with a focus to its application and R&D commercialization. Presenting innovation-based activities of rural agricultural companies in a business process format will facilitate their better adaptability to rapidly changing external environment, enable to assess the effectiveness of individual innovations as well as to detect the bottlenecks and errors and eliminate or mitigate them at the initial stage of innovation development. From the perspective of a process-based approach, the proposed model of managing innovative business processes of agricultural enterprises in rural areas provides an opportunity to: 1) benefit from effective use of innovative technology to achieve strategic goals of rural agricultural enterprises; 2) harmonize stakeholder interests of all rural agribusinesses and accumulate resources for their implementation) to provide rationale for agribusiness activities in rural areas in terms of ensuring their competitiveness; 4) to boost the profitability of rural agribusinesses and generate unused resources. The identification of such common elements contributes to better understanding of the logic of a systemic framework to manage innovative technology process based on business process compositional modeling. The findings demonstrate that step-by-step algorithm based on the proposed model will enable to carry out a sound assessment of the innovation potential of agricultural companies, build their sustainable competitive advantages along with contributing to creating a favourable environment to implement innovative development strategy in the agriculture industry and promote the application of technological innovations in manufacturing and management.
The Gamifying Teaching Elementary English: Word Search Game to Reach Vocabulary Mastery
Authors: Simatupang Devi Novita Sari , Derin Tatum 
Published: March 2021

The purpose of the research is to find out whether there is any significant effect of the word search game compared to the board game towards the students’ vocabulary mastery at the fourth grade SD Swasta Karya Tani Kandis. The design used in this research is experimental research. The location for this research was at SD Swasta Karya Tani Kandis. The vocabulary test was used to find out the students’ ability in vocabulary. The result of this research shown that the data obtained from the students’ pre-test to find the homogeneity to see the equal ability from both classes. and post-test scores of experimental classes 1 and 2 to know the different scores of two experimental classes. The test was to answer the questions based on the vocabulary test. Before treatment, the researcher gave the pre-test to IVA (experiment class 1) and IVB (experiment class 2). The researcher taught within 6 (Six) meetings including pre-test and post-test. Based on the data analysis it can be seen that Sig < 0,000. The value of sig (2-tailed) was 0.03 and it was lower than significant probabilities 5% (P< 0.05) in post-test experimental classes 1 and 2. Furthermore, there is a significant effect of using Word Search Game toward students’ vocabulary mastery fourth grade SD Swasta Karya Tani Kandis between experimental groups 1 and 2. In conclusion, there was a significant effect of using Word Search Game toward students’ vocabulary mastery.
ANALISIS KEMAMPUAN BERPIKIR KRITIS SISWA PADA MATA PELAJARAN MATEMATIKA
Authors: Dores ,S.Pd., M.Pd Olenggius Jiran , Wibowo Dwi Cahyadi , Susanti Susi 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui kemampuan berpikir kritis siswa pada mata pelajaran matematika dikelas IV Sekolah Dasar Negeri 03 Sebungkang tahun pelajaran 2020/2021. Subjek penelitian ini adalah seluruh siswa kelas IV SDN 03 sebungkang sebanyak 15 orang siswa. Pendekatan pada penelitian ini kualitatif dengan metode penelitian kualitatif sedangkan bentuk penelitian ini adalah deskriptif kualitatif. Berdasarkan hasil penelitian diperoleh: 1) kemampuan berpikir kritis siwa pada mata pelajaran matematika di kelas IV SDN 03 Sebungkang sebesar 29,58% kategori sangat rendah. Memahami masalah matematis untuk didiskusikan sebesar 63,33%, mengajukan alasan yang logis berupa konsep/ide sebagai bukti yang valid dan relevan sebesar 26,67%,menyimpulkan hubungan antara ide-ide untuk menyelesaikan masalah matematis sebesar 13,33%, dan mengambil tindakan berupa penyelesaian masalah matematis sebesar 15%. 2) faktor-faktor yang mempengaruhi kemampuan berpikir kritis siswa yaitu faktor psikologis yang terdiri dari perkembangan intelektual, motivasi, dan kecemasan, Faktor fisiologis yang terdiri dari kondisi fisik, faktor kemandirian belajar, dan faktor interaksi. 3) upaya yang dilakukan guru untuk meningkatkan kemampuan berpikir kritis siswa yaitu pengelolaan kelas, menggunakan pendekatan dan metode pembelajaran yang bervariasi, menciptakan interaksi antara guru dan siswa, dan melakukan evaluasi pembelajaran.
Clinical Management of Duchenne Muscular Dystrophy in the Netherlands: Barriers to and Proposals for the Implementation of the International Clinical Practice Guidelines
Authors: Heutinck Lotte , van Gameren Maaike , Verschuuren Jan J.G.M. , Geurts Alexander C.H. , Jansen Merel , de Groot Imelda J.M. 
Published: March 2021

Background: In order to successfully implement the international clinical care guidelines for Duchenne muscular dystrophy (DMD) in the Netherlands, it is essential to know what barriers are experienced by healthcare practitioners regarding guideline adherence and organization of care. In the Netherlands, academic medical centers provide follow up visits and work together with peripheral hospitals, rehabilitation centers, centers for home ventilation and primary care centers for treatment. Objective: To investigate perceived barriers to international clinical DMD guideline adherence and identify potential areas of improvement for implementation in the Dutch ‘shared care’ organization. Methods: Semi-structured in-depth interviews with healthcare practitioners of academic medical hospitals and questionnaires for healthcare practitioners of rehabilitation centers, based on the framework of Cabana. Results: The analyses identified 4 barriers for non-adherence to the DMD guideline: (i) lack of familiarity/awareness, (ii) lack of agreement with specific guideline, (iii) lack of outcome expectancy, (iv) external barriers. Conclusions: A heterogeneous set of barriers is present. Therefore, a multifaceted intervention strategy is proposed to overcome these barriers, including a clear division of roles, allowing for local (Dutch) adaptations per specialism by local consensus groups, and the facilitation of easy communication with experts/opinion leaders as well as between care professionals.
Baseline apparent diffusion coefficients: Validation study of new predictor of survival in patients with unresectable hepatocellular carcinoma following chemoembolization
Authors: Xu Lichao , Wang Shiqin , Wang Shengping , Wang Ying , Li Wentao , Lin Guangwu , Yuan Zheng 
Published: March 2021

OBJECTIVES: To investigate whether the baseline apparent diffusion coefficient (ADC) can predict survival in the hepatocellular carcinoma (HCC) patients receiving chemoembolization. MATERIALS AND METHODS: Diffusion-weighted MR imaging of HCC patients is performed within 2 weeks before chemoembolization. The ADC of the largest index lesion is recorded. Responses are assessed by mRECIST after the start of the second course of chemoembolization. Receiver operating characteristic (ROC) curve analysis is performed to evaluate the diagnostic performance and determine optimal cut-off values. Cox regression and Kaplan–Meier survival analyses are used to explore the differences in overall survival (OS) between the responders and non-responders. RESULTS: The difference is statistically significant in the baseline ADC between the responders and non-responders ( P < 0.001). ROC analyses indicate that the baseline ADC value is a good predictor of response to treatment with an area under the ROC curve (AUC) of 0.744 and the optimal cut-off value of 1.22×10–3 mm2/s. The Cox regression model shows that the baseline ADC is an independent predictor of OS, with a 57.2% reduction in risk. CONCLUSION: An optimal baseline ADC value is a functional imaging response biomarker that has higher discriminatory power to predict tumor response and prolonged survival following chemoembolization in HCC patients.
A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer
Authors: Cavalli M. , Diamanti K. , Pan G. , Dabrowski M.J. , Komorowski J. , Wadelius C. 
Published: March 2021

Background: Somatic mutations in coding regions of the genome may result in non-functional proteins that can lead to cancer or other diseases, however cancer mutations in the non-coding regions have rarely been studied and the interpretation of their effects is difficult. Non-coding mutations might act by breaking or creating transcription factor binding motifs in promoters, enhancers or silencers resulting in altered expression of target gene(s). A high number of mutations have been reported in coding and non-coding regions in cells of liver cancer. Hepatocyte nuclear factor 4α is a transcription factor that regulates the expression of several genes in liver cells, while the motifs it binds are frequently mutated in promoters and enhancers in liver cancer. Aim: The aim of the study is to evaluate the genetic effects of a non-coding somatic mutation frequently observed in liver cancer. Materials and Methods: We evaluated experimentally the effects of a somatic mutation frequently reported in liver cancer as a motif-breaker for the binding of hepatocyte nuclear factor 4α. The effects of the mutation on protein binding and enhancer activity were studied in HepG2 cells via electrophoresis mobility shift assay and dual luciferase reporter assays. We also studied genome-wide promoter-enhancer interactions performing targeted chromosome conformation capture in liver tissue to identify putative target genes whose expression could be altered by the mutation. Results: We found that the mutation leads to reduced protein binding and a decrease in enhancer activity. The enhancer harboring the mutation interacts with the promoters of ANAPC13, MAP6D1 and MUC13, which have been implicated in liver cancer. Conclusions: The study highlights the importance of non-coding somatic mutations, vastly understudied, but likely to contribute to cancer development and progression.
ROS production by circulating phagocytes and Guerin carcinoma resistance to cisplatin
Authors: Prokhorova I.V. , Gorbach O.I. , Yakshibaeva Yu.R. , Shliakhtova N.А. , Solyanik G.I. 
Published: March 2021

Background: Tumor drug resistance remains a primary cause of unsuccessful cancer therapy. The search for biological markers of the sensitivity/resistance of malignant neoplasms to drug therapy is an urgent and important task, the solution of which will increase the effectiveness of anticancer chemotherapy. Aim: To study the relationship between the functional activity (parameters of the phagocytosis and reactive oxygen species (ROS) production) of neutrophils and monocytes in the peripheral blood of rats with transplanted Guerin carcinoma and the degree of its sensitivity to cisplatin (Cpt). Materials and Methods: The original and Cpt-resistant variants of Guerin carcinoma were transplanted to female Wistar rats 2.5 months old. The parameters of the phagocytic activity of circulating neutrophils and monocytes were determined by the degree of ingestion of inactivated and FITC-labeled staphylococci using flow cytometry. The number of ROS-generating cells and the intensity of ROS production by phagocytes were determined by flow cytometry using 2’,7’-dichlorodihydrofluorescein diacetate. Results: The growth of both variants of Guerin carcinoma caused a statistically significant decrease in the intensity of neutrophil phagocytosis by more than 47% with a tendency to the reduction of the intensity of phagocytosis by monocytes. The phagocytic activity of circulating neutrophils and monocytes did not differ significantly between the groups of animals with the original and Cpt-resistant variant of Guerin carcinoma. In contrast, the intensity of ROS generation by both monocytes and neutrophils in the peripheral blood of animals with Cpt-resistant tumor increased by more than 86% as compared to original carcinoma-bearing rats. Conclusion: This study provides evidence that the intensity of ROS production by circulating monocytes and neutrophils may reflect the degree of tumor sensitivity to Cpt. Increased intensity of ROS production could serve as a pretreatment predictor of the formation of tumor drug resistance.
Ornithine decarboxylase activity in prostate cancer
Authors: Samoylenko O.А. , Stakhovsky E.O. , Vitruk Y.V. , Shlyakhovenko V.O. 
Published: March 2021

Summary. Prostate cancer (PCa), the most common solid malignant neoplasm in men, is characterized using the Gleason score and diagnosed using prostate-specific antigen (PSA) biomarker. However, Gleason score and PSA-based diagnostics are not universal and have significant limitations. It is supposed that the ornithine decarboxylase activity (AODC) could be a suitable auxiliary biomarker for the PCa diagnosis or monitoring the therapeutic efficacy. Aim: To assess the relation between AODC in PCa tissues and the level of serum PSA with the Gleason score (GS) and the clinical stage. Materials and Methods: 29 patients (48 to 79 years old) with prostate adenocarcinoma of different GS (6 to 10) and clinical stage (T1 to T4) were enrolled in the study. The AODC was analyzed in the PCa tissues by the modified spectrophotometric assay. Results: The patients with PCa were distributed into two groups: with low AODC < 0.3 and high AODC > 0.45. In group with AODC < 0.3, the highest value of AODC was recorded in patients with the lowest GS (= 6), while in group with AODC > 0.45, the highest value of AODC was recorded in the patients with the highest GS (= 9–10). Furthermore, in group with AODC > 0.45, the highest value of AODC was registered in the patients with T1 or T4 stage. The highest levels of serum PSA were detected in T3–T4 cases and in cases with the highest GS. Conclusion: The patterns of AODC and serum PSA can be used as supplementary indices useful for monitoring PCa course.
Varied Presentation of Oral Verrucous Carcinoma in a Tertiary Hospital of Dhaka City
Authors: Mamun Md Talal , Rahman Tarin , Haider Ismat Ara , Ripon Mohammad Rezaul Karim 
Published: March 2021

Introduction: Ackerman’s tumor or Verrucous carcinoma is a distinguished clinic-pathological variant of squamous cell carcinoma, presenting with multiple clinical presentations. This study provides a contemporary survey of morphological presentation of oral verrucous carcinoma (OVC) in the oral cavity with site of predilection and possible etiological factors.
Method: An observational studywas conducted from January 2014 to June 2016.A suspected patient diagnosed clinically and histologically as OVC at the Dhaka Dental College Hospital (DDCH) was enrolled in this study. Results: In this study total 15 number of patients male were 53.3% and female were 47%. The morphological presentation of the study was proliferative and verrucous, each of which comprises 40.0% of cases. The tumor's primary site was the buccal mucosa 46.67% and history ofbetel quid chewing was 46.9%.
Conclusion: The study concluded that it is very difficult to distinguishing clinically between verrucous carcinoma and other exophytic lesions of the oral cavity. OVC presents with different morphological presentation such as proliferative and verrucous types. Buccal mucosa is the site of predilection.
J Bangladesh Coll Phys Surg 2021; 39(2): 80-86
Giant Ovarian Tumor Presenting as a Huge Abdomino-Pelvic Mass in a Teenage Girl: A Case Report
Authors: Muhammad Jamaluddin - , Ahmed Hajrah Hilal 
Published: March 2021

Ovarian cysts are common causes of lower abdominal pain and abdominal distention in females. While most of them are benign and rarely grow immensely to achieve a huge size, they may be neoplastic in origin, reaching enormous dimensions with minimum or without raising any symptoms.Here, we present an interesting case of a 19-year-old female,who presented with huge abdominal swelling and pain in whole abdomen from whom a 9.1 kg borderline mucinous ovarian cyst, occupying the whole abdominal cavity was removed.
J Bangladesh Coll Phys Surg 2021; 39(2): 137-141