bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a Primary Care Program to Increase Physical Activity in People With Dementia and Their Family Caregivers (AFISDEMYF Study).
Authors: DE DIOS-RODRIGUEZ Elena , PATINO-ALONSO María C , GONZÁLEZ-SÁNCHEZ Susana , RIPOLL Joana , TAMAYO-MORALES Olaya , MORA-SIMÓN Sara , UNZUETA-ARCE Jaime , GÓMEZ-MARCOS Manuel A , GARCÍA-ORTIZ Luis , RODRÍGUEZ-SÁNCHEZ Emiliano 
Published: December 2021

Abstract
Aim: To evaluate the effectiveness of an intervention in primary health care designed to increase physical activity in people with dementia and their family caregivers.Methods: A cluster-randomized multicentre clinical trial was carried out.Participants: 140 people with dementia (median age 82 years;63.6% women) and 176 caregivers (median age 62 years ;72.7% women). Seventy patients and 80 caregivers were assigned to the Control Group (CG) and 70 patients and 96 caregivers to the Intervention Group (IG). The physical activity was measured with the pedometer and with the IPAQ-SF questionnaire. The intervention consisted of applying in primary care the program promoting physical activity (PEPAF) for 3 months. The changes observed at 6 months were analyzed. Results:In people with dementia, in the pedometer assessment a decrease was observed in both groups, but it was larger in the CG both in the total number step/day lower in the IG than in the CG and in the aerobic steps / day (52.89 vs -615.93). The activity reported with the IPAQ-SF decreased more in IG, both in the MET/min/week (-258.470 vs -148.23) and in the MVPA min/week. In caregivers the pedometer assessment showed that total steps/day increased more in the IG, as did aerobic steps/day (356.91 vs -12.95). The IPAQ-SF a smaller increase in global activity was declared in the IG than in the CG (545.25 MET/min/week vs 609.55), but the increase in vigorous activity was greater. No differences were found in changes in the functional status and the cognitive performances of people with dementia nor in the mental health in the caregivers, but systolic blood pressure, the Family APGAR and overload in the IG did improve.Conclusions: The results suggest that the intervention carried out may be effective on physical activity in both patients and caregivers. It can also improve systolic blood pressure, the Family APGAR and overload in caregivers. This is the first study to implement a primary care intervention aimed at simultaneously increasing physical activity in people with dementia and their relatives. These results reinforce the importance of using objective measures in clinical trials in people with dementia.Trial registration number: NCT 02044887.
More Adherence To A Mediterranean Dietary Pattern is Associated With A Lower Insomnia Score
Authors: yaghtin Zahra , Yuzbashian Emad , Ghayour-mobarhan Majid , Khayyatzadeh Sayyed Saeid 
Published: December 2021

Abstract
Background: Previous studies has shown that low quality diet is correlated with chronic sleep disorders. Mediterranean dietary pattern is considered as a high quality diet which has been shown to have beneficial effects on overall health. Thus, the aim of our study was to investigate the correlation between adherence to Mediterranean dietary pattern and insomnia score in a population of adolescent girls.Methods: Total Data of 734 adolescent girls between 12-18 years old has been considered in this cross-sectional study. To assess dietary intake, a food frequency questionnaire was used. To assess the inherence to Mediterranean dietary style, a modified model of Mediterranean diet was applied and the scores were ranged from 0-9. A valideated version of Insomnia Severity Index questionnaire wss used to assess insomnia. To explore the associations between MED-style diet and insomnia, logistic regression was conducted in crude and adjusted models.Results: The participants with higher adherence to MED-style diet had higher intake of fruits, vegetables, nuts, fish, total energy intake, carbohydrate, dietary fiber, potassium, Beta-carotene, vitamin C, iron and folate. A significant inverse association between adherence to the MED-style diet score and insomnia score was obtained in crude model (β= -0.125; P-value = 0.019) and also after adjustment for confounding variables (β= -0.120; P=0.048).Conclusion: There is an inverse relationship between adherence to the Mediterranean dietary style and the prevalence of insomnia among Iranian adolescent girls. Prospective studies are necessary to confirm these results and clarify whether a causal relationship exists.
Professional Self-Understanding of Teachers in Different Career Stages: A Phenomenological Analysis
Authors: Yağan Ersin , Özgenel Mustafa , Baydar Fatih 
Published: December 2021

Abstract
Teachers’ sense of identity plays a central role in understanding their actions as individuals inside and outside the classroom. Therefore, it is important to determine teachers’ understanding of who they are. Thus, teachers’ opinions about their professional self-understanding in the study were aimed to be analysed. In line with this purpose, the qualitative research method was used to address teachers’ views on their professional self-understanding holistically, and the research was carried out according to the phenomenology pattern. The research study group consists of 44 teachers working in primary, secondary, and high schools located in the Pendik district of Istanbul. Research data were obtained as a result of in-depth interviews with teachers through semi-structured interview forms. The findings obtained were grouped under five themes: “Image, Respect, Job Motivation, Perception of Duty, and Future Views”, taking into account the relevant literature. The study revealed that professional self-understanding is closely affected by emotions and teachers’ social status.
Therapeutic Exercise to Improve Motor Function Among Children with Down Syndrome Aged 0 to 3 Years: A Systematic Literature Review
Authors: Rodríguez-Grande Eliana-Isabel , Buitrago-Lopez Adriana , Torres-Narvaez Martha-Rocio , Serrano-Villar Yannely , Verdugo-Paiva Francisca , Ávila Camila 
Published: December 2021

Abstract
Objective: To determine the effect of therapeutic exercises on the motor function of children with Down syndrome (DS) aged 0 to 3 years.Data Sources: A search was carried out on PubMed, PEDro, EMBASE, SCIELO, Lilacs, Cochrane library without publication date restrictions for the terms.Study Selection: The search yielded 1384 eligible articles, which were screened by 2 reviewers. RCTs that would have evaluated the effectiveness of therapeutic exercise were selected, and that would have reported the effectiveness in the outcomes.Data Extraction: The methodology and results of the studies were critically appraised in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines. Data Synthesis: Six studies were included. Two types of therapeutic exercises, aerobic and neuromuscular, were identified. A therapeutic aerobic exercise was performed using the treadmill, while a neuromuscular exercise was done using unstable surfaces. The exercise frequency ranged from three days to five days a week, and the duration of each session was between six and 15 minutes. Conclusion: There is moderate to high evidence to support that therapeutic exercise promotes the occurrence of motor patterns such as gait patterns and enhances the motor skills of children with DS aged 0 to 3 years.
Development and Validation of an Apoptosis-Related Genes Signature in Patients with Gastric Cancer
Authors: Yang Jianqiao , Shang Liang , Li Leping , Wang Zixiao , Dong Kangdi , Li Han , Liu Jin 
Published: December 2021

Abstract
Background: Gastric cancer (GC) is a common malignant tumour of the digestive tract. the prognosis of GC patients is still not optimistic. Apoptosis-related genes (ARGs) plays an important role in the development, invasion, metastasis and drug resistance of GC. Therefore, assessing the interaction between ARGs and the prognosis of GC patients may help identify specific biomarkers.Methods: Differentially expressed genes (DEGs) were identified by integrating gene expression profiling analyses from The Cancer Genome Atlas (TCGA) GC cohort and Gene Set Enrichment Analysis (GSEA) Database. Then, a risk score model was built based on Kaplan-Meier (K-M), least absolute shrinkage and selector operation (LASSO), and multivariate Cox regression analyses. Another cohort (GSE84426) was used for external validation. By combining risk scores with clinical variables, a nomogram was constructed to predict the prognosis of GC patients. Results: We screened 39 DEGS and established a three-gene signature(CAV1、F2、LUM) based on 161 ARGs. In addition, three-gene signature was identified as an independent factor in predicting the prognosis of GC patients and validated in an external independent cohort. Finally, we developed a nomogram that can be applied to clinical practice.Conclusions: Our study established a three-gene signature of GC based on ARGs that has reference significance for in-depth research on the apoptosis mechanism of GC and the exploration of new clinical treatment strategies.
Sodium citrate-assisted prussian blue analogues as K-rich cathode materials for sodium ion batteries
Authors: li Peng , Gu Genfei , Jiang Yong , Cui Baoyin , Sun Minrui , Zheng Shiyou 
Published: December 2021

Abstract
Prussian blue analogue (PBA), as the cathode material of sodium ion batteries (SIBs), has attracted much attention because of its low price and open three-dimensional channel structure. However, the traditional methods for preparing PBA have high crystallization rate, high water content and many structural defects, which hinder the development of PBA for the application of in batteries. To solve the above problems, in this study, sodium citrate was used to improve the nucleation rate and crystallinity. Herein, PBM1 synthesized by this method not only has good crystallinity and regular particles, but also shows excellent electrochemical performance when used as cathode in SIBs. Under the current density of 0.05A/g, it has a specific capacity of 109.6 mAh/g. At a current density of 0.1A/g, the reversible specific capacity could keep as high as 95.0 mAh/g and with a coulombic efficiency of almost 100% after 300 cycles.
Comparative Transcriptomic Analysis of Two Cucumis Melo Var. Saccharinus Germplasms Differing in Fruit Physical and Chemical Characteristics
Authors: Liang Renfan , Su Yicheng , Qin Xiaojuan , Gao Zhongkui , Fu Zhixin , Qiu Huijun , Lin Xu , Zhu Jinlian 
Published: December 2021

Abstract
Background: Hami melon (Cucumis melo var. saccharinus) is a popular fruit in China noted for its excellent taste, which is largely determined by its physical and chemical characteristics, including flesh texture, sugar content, aroma, and nutrient composition. However, the mechanisms through which the associated with these characteristics are regulated have not yet been sufficiently determined. In this study, we monitored changes in the fruits of two germplasms differing in physical and chemical characteristics throughout the period of fruit development. Results: Ripe fruit of the bred variety ‘Guimi’ had significantly higher soluble sugar contents than the fruit of the common variety ‘Yaolong’, whereas differences in fruit shape and color between these two germplasms were observed during the course of development. Comparative transcriptome analysis, conducted to identify regulators and pathways underlying the observed differences at corresponding stages of development, revealed a higher number of differentially expressed genes (DEGs) in Guimi than in Yaolong. Moreover, most of the DEGs detected during early fruit development of Guimi were associated with cell wall biogenesis. Temporal analysis of the identified DEGs revealed similar trends in the enrichment of downregulated genes in both germplasms, although there were certain differences in the enrichment trends of upregulated genes. Further analyses revealed trends in the differential changes of multiple genes involved in cell wall biogenesis and sugar metabolism during fruit ripening.Conclusions: We were thus able to identify a number of genes associated with the ripening of Hami melon, which will accordingly provide novel insights into the molecular mechanisms underlying the development of fruit characteristics in these melons.
Accurate THz Ellipsometry Using Calibration in Time Domain
Authors: Mazaheri Zahra , Koral Can , Andreone Antonello 
Published: December 2021

Abstract
We report on the realisation of a customized THz Time Domain Spectroscopic Ellipsometer (THz-TDSE) based on fiber-coupled photoconductive antennas, operating in a wide range of incident angles and allowing also standard transmission spectroscopy without any optical realignment. To ensure accurate parameter extraction for a broad range of materials, we developed a fast and effective algorithm-assisted method to calibrate the setup and compensate for the nonideality in the response of the THz system. The procedure allows to minimise errors induced by imperfect response of the antennas and polarizers, imprecise setting of the impinging and receiving angles in the goniometric mechanical arms, and unavoidable mismatches in the THz beam optics. Differently from other calibration methods applied in the literature, our approach compares in time domain the ellipsometric derived electric field s- and p-polarised components at a given angle of incidence with the reconstructed ones, attained by using the complex dielectric function of a known sample. The calibrated response is determined with high precision by setting the system in transmission mode. In order to validate the technique, ellipsometric measurements have been carried out at various angle of incidences on a number of materials both in solid and liquid form, and their data compared with what obtained by conventional THz spectroscopy. Results show that THz-TDSE accompanied with an accurate calibration procedure is an effective technique for material characterization, especially in case of samples with a high absorption rate that are not easily investigated through transmission measurements.
Automated vitrification of cryo-EM samples with controllable sample thickness using suction and real-time optical inspection
Authors: Koning Roman , Vader Hildo , Nugteren Martijn van , Grocutt Peter , Yang Wen , Renault Ludovic , Koster Abraham , Kamp Arnold , Schwertner Michael 
Published: December 2021

Abstract
Speed and efficiency of data collection and image processing in cryo electron microscopy have increased over the last decade. However, cryo specimen preparation techniques have lagged behind and faster, more reproducible specimen preparation devices are needed. Here we present a new vitrification device with highly automated sample handling, requiring only limited user interaction. Moreover, the device allows inspection of thin films using light microscopy, since excess liquid is removed through suction by tubes, not blotting paper. In combination with dew-point control, this enables thin film preparation in a controlled and reproducible manner. The advantage is that quality of the prepared cryo specimen is characterized prior to electron microscopy data acquisition. Practicality and performance of the device are illustrated by experimental results obtained by vitrification of protein suspensions, lipid vesicles, bacterial and human cells, followed by imaged using single particle analysis, cryo electron tomography and cryo correlated light and electron microscopy.
DDPG-Based Continuous Thickness and Tension Coupling Control for the Unsteady Cold Rolling Process
Authors: Zeng Wenying , Wang Jinkuan , Zhang Yan , Han Yinghua , Zhao Qiang 
Published: December 2021

Abstract
Cold rolling is an important part of the iron and steel industry, and the unsteady rolling process of cold rolling usually brings significant influences on the stability of product quality. In the unsteady rolling process, various disturbances and uncertainties such as variable lubrication state, variable equipment working conditions lead to difficulties in the establishment of state space model of thickness and tension, which has become a thorny problem in thickness and tension control. In this paper, we present a model-free controller based on Deep Deterministic Policy Gradient(DDPG), which can continuously control the thickness tension of the unsteady rolling process without the mathematical model. We first formulate the thickness and tension control problem to Markov Decision Process(MDP). We apply strategies such as dividing state space variables with mechanism model, defining reward function and state normalization, the random disturbance and complex uncertainties of unsteady cold rolling process are coped with by utilizing the DDPG controller. In addition, these strategies also ensure the learning performance and stability of the DDPG controller under random disturbance. Simulations and experiments show that the proposed the DDPG controller does not require any prior knowledge of uncertain parameters and can operate without knowing unsteady rolling mathematical models, which has better accuracy, stability and rapidity for thickness and tension in the unsteady rolling process than proportional integral(PI) controller. The artificial intelligence-based controller brings both product quality improvement and intelligence to cold rolling.
Prevalence of Peptic Ulcer Disease and Associated Factors Among Dyspeptic Patients At Endoscopy Unit, University of Gondar Hospital, Northwest Ethiopia
Authors: Assefa Belete , Tadesse Abilo , Abay Zinahebizu , Abebe Alula , Tesfaye Tsebaot , Tadesse Melaku , Lakew Ayenew Molla 
Published: December 2021

Abstract
Background: Dyspepsia is a common complaint in upper gastrointestinal disorders. It is described as predominant epigastric pain lasting for at least one month. Peptic Ulcer Disease (PUD) occurs in 5-15% of patients with dyspepsia. Helicobacter pylori (H.pylori) infection and non-steroidal anti-inflammatory drugs (NSAIDs)/aspirin (ASA) use are widely known risk factors for PUD. This research article aimed to determine the prevalence of PUD and associated factors among dyspeptic patients at the endoscopy unit, University of Gondar hospital, Northwest Ethiopia.Methods: A hospital-based cross-sectional study was conducted at University of Gondar hospital. A sample of 218 adults who presented with the complaint of dyspepsia, and underwent endoscopic evaluation were interviewed from June 1 to November 30, 2020. A consecutive sampling method was used to recruit the study subjects. Relevant clinical history was obtained from patients’ medical records. Upper gastrointestinal endoscopy was used to confirm the presence of peptic ulcer disease. The Data were entered into EpiData version 4.6.0.2 and exported to SPSS version 20 for analysis. Logistic regression analysis was used to identify associated factors with the occurrence of PUD among dyspeptic patients. P-value <0.05 was used to declare a statistically significant association.Results: A total of 218 dyspeptic patients who underwent upper gastrointestinal endoscopic evaluations were included in the study. The PUD was diagnosed in one-third of patients with dyspepsia. Dyspeptic patients with active H. pylori infection (AOR=6.3, 95%CI: 2.96-13.38) and NSAIDs/ASA use (AOR=6.2, 95%CI: 2.93-13.36) were at higher risk of developing PUD.Conclusion: The magnitude of active H. pylori infection among symptomatic PUD patients was high. So then, a “test-and-treat” strategy is advised. Cautious use of NSAIDs/ASA is required as it is readily available over-the-counter.
Solvation Structure and Interfacial Regulation for Extremely Stable Zinc Metal Anodes Operating in a Wide Range of Temperatures
Authors: Xiong Peixun , Kang Yingbo , Yao Nan , Chen Xiang , Zeng Lingxing , Dou Qingyun , Han Xiaotong , Rana Harpalsinh , Tian Zhenchuan , Park Jeong Hee , Zhang Qiang , Park Ho Seok 
Published: December 2021

Abstract
Aqueous zinc-metal batteries are promising for large-scale energy storage owing to their reasonable energy density, safety and low cost. However, their practical applications are limited by hydrogen evolution, corrosion, and dendrite formation of Zn anode and there is trade-off between efficiency and stability at high and low temperatures. Herein, we propose a solvation chemistry regulation strategy that can adjust the Zn2+-solvation structure and in situ form a robust and Zn2+-conducting Zn5(CO3)2(OH)6 SEI on the Zn surface, using hybrid electrolytes of water and a polar aprotic N, N-dimethylformamide. As verified by experimental characterizations and computational analyses, the unique solvation structure and the newly formed solid electrolyte interface are created by hybrid electrolytes, resulting in highly reversible and dendrite-free Zn plating/stripping process as well as thermal stability and high ionic conductivity from −30 to 70 °C. The Zn||Zn symmetric cells in hybrid electrolytes are very stable over 2500 h at 25 ℃ and 2000 h even at –20 ℃. Thus, the stability and reversibility of the hybrid zinc-ion capacitors with Zn metal anode in hybrid electrolytes are firstly achieved in a wide and extreme temperature range, demonstrating high capacity retentions and Coulombic efficiencies over 14000, 10000, and 600 cycles at 25, −20, and 70 ℃, respectively.
Ethical challenges in palliative sedation of adults: protocol for a systematic review of current clinical practice guidelines
Authors: TOMCZYK Martyna , JAQUES Cécile , JOX Ralf J. 
Published: December 2021

Abstract
Introduction:

This study aims to identify the full spectrum of ethical challenges of all forms of palliative sedation for adults as presented in current clinical practice guidelines (CPGs), and to determine whether CPGs specify ethical challenges of this therapy for cancer and non-cancer patients and, if so, how exactly they do this. To the best of our knowledge, no studies have yet investigated this topic. The purpose is purely descriptive; our aim is not to make any kind of normative judgements on these challenges. Nor is our aim to assess the quality of the CPGs.
Methods and analysis

: We will perform a systematic review of CPGs on palliative sedation for adults via five electronic databases, grey literature search tools, citation tracking, and contact with palliative care experts. Current CPGs validated by an international, national, or regional authority, published in English, German, French, Italian, or Polish, from 2000 to the date of the search, will be subjected to content analysis at the textual, linguistic, and thematic levels. This study protocol is reported in accordance with the PRISMA-P criteria and registered on PROSPERO.
Discussion

The results of our systematic review can help raise awareness and understanding of the complexity of ethical problems, rigorously guide reflection in this field, and be useful in elaborating ethical guidelines in an interdisciplinary approach, in order to have a positive impact on the quality of patient care, education and training, and research in respect of this complex and challenging practice.