bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plantago lanceolata – An overview of its agronomically and healing valuable features
Authors: Pol Michal , Schmidtke Knut , Lewandowska Sylwia 
Published: July 2021

Abstract
This article gives an overview of the widely distributed herb ribwort plantain (Plantago lanceolata). Currently, this plant is mostly grown in grasslands, rarely in arable land, and its secondary metabolites are used in medicine. Studies cited in the article indicate its very rapid growth and deep rooting in the soil, which results in high drought tolerance and uptake of valuable nutrients from deep soil layers. An intensive symbiosis with various mycorrhizal fungi is characteristic of plantain for a high capacity for nutrient and water appropriation. It is also characterized by different contents of iridoid glycosides like aucubin and catalpol in shoots and roots of different varieties. The use of P. lanceolata is discussed on permanent and non-permanent grasslands where agriculturally specific varieties have been developed for grazing animals showing positive health effects in them. Information is provided on the cultivation of ribwort plantain, including studies on sowing and fertilization, the yield and infestation of the plant with pathogens, and the occurrence of iridoid glycosides in the plant. In addition, information is included on pests that threaten the plant’s cultivation.
Enhancing the Stability of Asphalt Emulsion Using Environmentally Friendly Cationically Modified Hydroxyethyl Cellulose (CMHEC) at Different Concentrations and pH Values
Authors: Wang Xiaoxi , Hou Runhan , Zhang Qian , Darwesh Osama M. , Gao Mengyao , Zhang Zixu , Wang Yuexin 
Published: July 2021

Abstract
The cationically modified hydroxyethyl cellulose (CMHEC) was synthesized successfully and applied for preparing the cationic asphalt emulsion. The apparent viscosity and phase separation of the emulsion were studied at different CMHEC concentrations and pH values. The results indicated that the apparent viscosity of the emulsion was increased with increasing CMHEC concentration, and the phase separation was significantly reduced correspondingly. In addition, the effect of pH value on the emulsion quality was involved. The apparent viscosity of the emulsion showed the tendency to decrease firstly and then increase to the minimum value at pH 2. All results indicated that CMHEC has excellent potential in the manufacture of asphalt emulsion and the research of the pH effect on the formulation of asphalt emulsion has essential significance.
Numerical treatment of squeezing unsteady nanofluid flow using optimized stochastic algorithm
Authors: Nouar Ahcene , Dib Amar , Kezzar Mohamed , Sari Mohamed R. , Eid Mohamed R. 
Published: July 2021

Abstract
In this paper, very efficient, intelligent techniques have been used to solve the fourth-order nonlinear ordinary differential equations arising from squeezing unsteady nanofluid flow. The activation functions used to develop the three models are log-sigmoid, radial basis, and tan-sigmoid. The neural network of each scheme is optimized with the interior point method (IPM) to find the weights of the networks. The confrontation of the obtained results with the numerical solutions shows good accuracy of the three schemes. The obtained solutions by utilizing the neural network technique of our variables field (velocity and temperature) are continuous contrary to the discrete form obtained by the numerical scheme.
Influence of Angiotensin Converting Enzyme I/D Polymorphism on Hemodynamic and Antioxidant Response to Long-Term Intradialytic Resistance Training in Patients With Chronic Kidney Disease: A Randomized Controlled Trial
Authors: Corrêa Hugo de Luca , Deus Lysleine A. , Neves Rodrigo V.P. , Reis Andrea L. , de Freitas Giovana S. , de Araújo Thaís B. , da Silva Barbosa Jessica M. , Prestes Jonato , Simões Herbert G. , Amorim Carlos E. , dos Santos Marcos A.P. , Haro Anderson , de Melo Gislane F. , Gadelha André B. , Neto Luiz Sinésio S. , Rosa Thiago dos Santos 
Published: July 2021

Abstract
Corrêa, HdL, Deus, LA, Neves, RVP, Reis, AL, de Freitas, GS, de Araújo, TB, da Silva Barbosa, JM, Prestes, J, Simões, HG, Amorim, CE, dos Santos, MAP, Haro, A, de Melo, GF, Gadelha, AB, Neto, LS, and Rosa, TdS. Influence of angiotensin converting enzyme I/D polymorphism on hemodynamic and antioxidant response to long-term intradialytic resistance training in patients with chronic kidney disease: a randomized controlled trial. J Strength Cond Res 35(10): 2902–2909, 2021—The aim of the study was to verify the influence of Angiotensin-converting enzyme (ACE) I/D genotype on blood pressure, muscle mass, and redox balance response to long-term resistance training (RT) in end-stage renal disease patients. Three hundred and twenty subjects were randomized into 4 groups: II + ID control (II + ID CTL, n = 80), II + ID RT (II + ID RT, n = 79), DD control (DD CTL n = 83), and DD RT (DD RT, n = 78). The RT lasted 24 weeks with a frequency of 3 times per week, on alternative days. Each section consisted of 3 sets of 8–12 repetitions in 11 exercises, with training loads at 6 point (somewhat hard) to 8 point (hard) based on OMNI-RES scale and was prescribed during dialysis (intradialytic). Statistical significance was accepted with p < 0.05. The most relevant benefits in blood pressure were found for DD homozygotes (p < 0.0001), whereas allele I carriers displayed a higher increase in muscle mass (p < 0.0001). Hemodialysis clinics that already use RT for their patients could include the genotyping of ACE to identify the predisposal of the patients to respond to RT and to counteract kidney disease-related comorbidities.
Community SARS-CoV-2 Surge and Within-School Transmission
Authors: Zimmerman Kanecia O. , Brookhart M. Alan , Kalu Ibukunoluwa C. , Boutzoukas Angelique E. , McGann Kathleen A. , Smith Michael J. , Maradiaga Panayotti Gabriela M. , Armstrong Sarah C. , Weber David J. , Moorthy Ganga S. , Benjamin Daniel K. 
Published: July 2021

OBJECTIVES
When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began, experts raised concerns about in-person instruction in the setting of high levels of community transmission. We describe secondary transmission of SARS-CoV-2 within North Carolina kindergarten through 12th-grade school districts during a winter surge to determine if mitigation strategies can hinder within-school transmission.

METHODS
From October 26, 2020, to February 28, 2021, 13 North Carolina school districts participating in The ABC Science Collaborative were open for in-person instruction, adhered to basic mitigation strategies, and tracked community- and school-acquired SARS-CoV-2 cases. Public health officials adjudicated each case. We combined these data with that from August 2020 to evaluate the effect of the SARS-CoV-2 winter surge on infection rates as well as weekly community- and school-acquired cases. We evaluated the number of secondary cases generated by each primary case as well as the role of athletic activities in school-acquired cases.

RESULTS
More than 100 000 students and staff from 13 school districts attended school in person; of these, 4969 community-acquired SARS-CoV-2 infections were documented by molecular testing. Through contact tracing, North Carolina local health department staff identified an additional 209 infections among &gt;26 000 school close contacts (secondary attack rate &lt;1%). Most within-school transmissions in high schools (75%) were linked to school-sponsored sports. School-acquired cases slightly increased during the surge; however, within-school transmission rates remained constant, from presurge to surge, with ∼1 school-acquired case for every 20 primary cases.

CONCLUSIONS
With adherence to basic mitigation strategies, within-school transmission of SARS-CoV-2 can be interrupted, even during a surge of community infections.
Games e moralidade: como os jogadores se relacionam com os conteúdos morais dos jogos?
Authors: Evangelista Vítor de Morais Alves , Kadooka Aline , Lepre Rita Melissa 
Published: July 2021

INTRODUÇÃO: Os jogos eletrônicos se tornaram parte fundamental de uma sociedade marcada pelo uso da tecnologia e pela virtualização das relações humanas. Considerados como produto de uma cultura de consumo tecnológica recente, os jogos apresentam a seu respeito diversas opiniões contraditórias, principalmente às que se referem aos seus conteúdos morais e suas supostas influências. OBJETIVO: A presente pesquisa tem como objetivo analisar como os jogadores se relacionam com os conteúdos morais presentes nos jogos eletrônicos. METODOLOGIA: Trata-se de um estudo quanti-qualitativo envolvendo 30 jogadores. Recorreu-se a entrevistas semiestruturadas com a apresentação de dilemas virtuais baseados em jogos eletrônicos. As entrevistas foram transcritas e analisadas por meio de análise de conteúdo e estatística descritiva, sendo os resultados discutidos à luz das teorias morais. RESULTADOS E DISCUSSÃO: Os resultados apontam que a maioria dos jogadores considera o ambiente virtual como um espaço de permissividade, satisfação dos desejos e livre de qualquer sanção, apresentando um número bem maior de respostas utilitaristas aos videodilemas. CONCLUSÃO:Os resultados sugerem que a ação moral no ambiente virtual pode ser vista como um construto independente para o julgamento moral.
Низовая организация досуга в заброшенных зданиях Воркуты
Authors: Литвинова София Александровна , Кузинер Евгения Николаевна , Гладченко Екатерина Андреевна 
Published: July 2021

В условиях институциональных и пространственных ограничений молодежь в Воркуте активно осваивает нефункционирующие заброшенные здания. Цель данной статьи — представить результаты исследования особенностей низовой организации досуга в заброшенных городских пространствах Воркуты, а также результаты анализа переплетений социальных и пространственных аспектов существования в городе различных молодежных групп, которые самостоятельно организуют досуг, создавая уникальные досуговые пространства в ситуации ограниченности ресурсов.
Для исследования были выбраны два кейса: байк-клуб «Полярные волки» и скейт-площадка в заброшенном здании. Эмпирический материал исследования был собран в ходе социологической экспедиции 7–13 июля 2019 года в Воркуте в рамках проекта «Открываем Россию заново» и включает в себя 20 глубинных интервью с воркутинцами в возрасте от 16 до 35 лет, а также более 200 часов включенного наблюдения. При анализе материала авторы опирались на сценовой подход и концепцию третьих мест Рэя Ольденбурга. При этом досуговое пространство молодежи определяется в исследовании как место, в котором существует молодежная сцена (или сцены). Для определения сцены и последующего анализа материала используется концепт «культурной сцены», предложенный Еленой Омельченко и Святославом Поляковым, где сцены — это связь досуговых практик сообществ и культурных пространств. В ходе анализа были выделены особенности низовой организации досуговых пространств в Воркуте — молодежь повторно использует заброшенные здания и создает внутри них свой особый социальный и связанный с ним пространственный порядок. Авторы пришли к заключению, что постоянные преобразования зданий молодежью являются развитием и продолжением сцены. Когда-то заброшенные здания становятся местами с определенной социальной динамикой, которая постоянно воспроизводится через пересечение повседневных практик участников сцен.
Поскольку исследованиям организации досуга молодежи в отдаленных от Центральной России арктических городах уделяется мало внимания, результаты данной статьи способны привлечь ученых к изучению форм досуга молодежи в регионах Арктики как ответа на институциональные ограничения в месте проживания.
Clinical and morphological portrait of tumors with microsatellite instability
Authors: Musaelyan A. A. , Nazarov V. D. , Budnikova A. S. , Lapin S. V. , Vorobyev S. L. , Emanuel V. L. , Zakharenko A. A. , Orlov S. V. 
Published: July 2021

Background. Microsatellites are short tandem nucleotide repeats, the change in length of which plays a key roles in the pathogenesis of various malignant neoplasms. This change is called microsatellite instability. It is caused by aberrations in the genes of DNA mismatch repair system. Tumors with microsatellite instability are a special subtype regardless of location and are characterized by high sensitivity to immune checkpoint inhibitors.Objective – determination of characteristic clinical and morphological patterns of tumors of various localizations with microsatellite instability.Materials and methods. The study included 512 patients with malignant tumors of different localizations. Of these, 359 patients were diagnosed with colorectal cancer, 57 with uterine body cancer, and 57 with stomach cancer. Determination of the status of microsatellite instability was performed by a PCR-based method using 5 mononucleotide markers: BAT-25, BAT-26, NR-21, NR-24, NR-27.Results. The prevalence of microsatellite instability in colorectal cancer, uterine neoplasm and gastric cancer was 6.4; 22.8 and 1.75 %, respectively. Patients with MSI-positive colorectal cancer are characterized by yonger age (p = 0.023), right-sided localization of the tumor (p <0.0001), presence of multiple primary tumors (p = 0.0299), poorly differentiation (p = 0.0025), mucinous component (p <0.0001), tumor-infiltrating lymphocytes (p <0.0001) and Crohn-like reaction (p = 0.0006). Patients with uterine neoplasms with microsatellite instability are characterized by the presence of endometrial adenocarcinoma (p = 0.047), as well as the presence of tumor-infiltrating lymphocytes (p = 0.0022) and cribriform growth (p = 0.0011).Conclusion. A common pattern for colorectal cancer and uterine neoplasms is the presence of tumor-infiltrating lymphocytes. Certain clinical and morphological features of tumors of these localizations will more accurately identify candidates for microsatellite instability status determination for further immunotherapy.
Chemoreactome screening of pharmaceutical effects on SARS-CoV-2 and human virome to help decide on drug-based COVID-19 therapy
Authors: Torshin I. Yu. , Gromova O. A. , Chuchalin A. G. , Zhuravlev Yu. I. 
Published: July 2021

Background. So-called rational drug design is suboptimal when it comes to finding effective and safe drug-based treatment for COVID-19. Another approach seems promising: to reprofile the pharmaceuticals registered in the Anatomical, Therapeutic, and Chemical Classifier (ATC).Material and methods. Chemoreactome screening, a method that simulates the results of inhibiting viral growth in a cell culture, models the effects of pharmaceuticals on the human virome, and estimates the adverse effects of medicines, was used to reprofile about 2700 pharmaceuticals from the ATC. The information technology behind chemoreactome analysis is based on the topological recognition theory advanced by the Institute of Pharmaceutical Informatics, Federal Research Center for Informatics and Control, Russian Academy of Sciences.Results. Sixty two pharmaceuticals and 20 micronutrients were found to have a pronounced antiviral effect with minimal side effects. Comparison against data of basic research and clinical trials showed 31 out of 62 pharmaceuticals to have been independently confirmed usable in COVID-19 treatment. These inhibit coronaviral proteins and/or function as adaptogenic molecules that improve the functioning of cells exposed to viral stress. Glucosamine sulfate was found to have the best safety profile and minimum effects on the healthy human virome out of all the tested anticoronaviral micronutrients.Conclusions. Reprofiling of pharmaceuticals registered in the ATC could significantly speed up the search for more effective and safer drugbased COVID-19 treatments. Several micronutrients show promise for long-term coronavirus prevention, especially in the elderly.
Effect of vitamin D intake on quality of life parameters in office workers
Authors: Sharman A. T. , Adambekov Sh. K. , Imandosova A. A. , Elemesova G. F. 
Published: July 2021

Objective: to study the prevalence of vitamin D deficiency and analyze the results of therapy in office workers, including an assessment of the quality of life.Material and methods. An observational non-interventional cross-sectional, cohort, prospective phase IV clinical study included office workers (151 people, age 18–44 years), who were prescribed an aqueous solution of vitamin D. The concentration of 25(OH)D in the blood of patients was measured before and after undergoing treatment. The duration of therapy, depending on the degree of deficiency, was 4 or 8 weeks. The SF-36 scale was used to assess the physiological and psychological status.Results. In 75.5% of the study participants, a insufficiency or deficiency of vitamin D was detected. Differences in the average content of 25(OH)D in blood serum before and after treatment with vitamin D were statistically significant. The level of vitamin D in blood serum, measured by the content of its metabolite 25(OH)D <30 ng/ml, is regarded as suboptimal, i.e. its insufficiency occurs, and <20 ng/ml – as vitamin D deficiency (p<0.0001). The SF-36 score showed significant statistically significant improvements in overall health, physical functioning, and pain in individuals with vitamin D deficiency after vitamin D supplementation. The use of multiple linear regression demonstrated an association of serum 25(OH)D levels with vitamin D-rich foods taken less than once a week.Conclusions. Vitamin D deficiency is very common among office workers: 75.5% had D 25(OH)D levels below 30 ng/ml. Vitamin D deficiency is corrected by taking this vitamin. Vitamin D supplementation helps to improve physical and mental health indicators. Serum 25(ОН)D levels are associated with intake of vitamin D-rich foods and duration of vitamin D treatment.
Medical care payment improvement within diagnosis-related groups of patients with severe asthma requiring biologic disease-modifying drugs by regional adaptation mechanism in the Moscow Region
Authors: Ermolaeva A. D. , Krysanova V. S. , Ermolaeva T. N. , Polyakova K. I. , Kokushkin K. A. 
Published: July 2021

Objective: scientific rationale of changing approaches to medical care payment for hospitalization of patients suffering from severe asthma (SA) that require the prescription of biologic disease-modifying drugs (bDMDs) within the constraints of diagnosis-related groups (DRGs) on the level of the Moscow Region.Material and methods. For the federal model regional adaptation, the authors used the mechanism of subgroups selection in the structure of basic DRG No. 336 st36.003 and No. 139 ds36.004 “Treatment with biologic disease-modifying drugs and selective immunosuppressants” in the round-the-clock (RH) and day-time hospital (DH). Budget impact analysis (BIA) was performed to provide scientific and economic feasibility for the improvement of medical care payment for bDMDs proscribed to patients with SA within DRG at the level of the Moscow Region.Results. The analysis of cost of drug therapy and medical services per 1 case of hospitalization of patients with SA, that required bDMDs therapy, considering the classification criterion (international nonproprietary name of drugs and drug therapy regimens), showed 10 subgroups in DRG No. 336 st36.003 (level 1) and 9 subgroups in DRG No. 139 ds36.004. Expert estimates on the rate of hospitalizations and drug dosage regimen indicated for patients with SA were used to calculate the relative cost weights (CW). The highest CW was observed in the subgroup that received benralizumab in RH (CW=7.46) and in DH (CW=12.08) conditions. BIA demonstrated 110,103,901.53 rubles (or 31%) budget savings for the health care system of the Moscow Region.Conclusion. The implementation of the adapted DRG federal model in the conditions of the health care system of Moscow Region is an economically feasible approach to the organization of the inpatient medical care provided to patients with SA needing bDMDs prescription.
AVRUPA’NIN YÜKSELEN EKONOMİLERİNDE BÜTÇE AÇIĞININ ENFLASYON ÜZERİNDEKİ ETKİSİ: PANEL ARDL YAKLAŞIMI
Authors: DOĞAN Bahadır Sazak , GÜNEL Tuğay 
Published: July 2021

Bütçe açığı ile enflasyon arasındaki karşılıklı ilişki, kamu maliyesi literatüründe yüksek öneme haiz olan tar-tışmalı konu başlıklarından bir tanesidir. İlgili çerçevede, makroekonomik göstergelerden bir tanesi olan enf-lasyonu düşük seviyelerde tutmak ise zaman ve coğrafyadan bağımsız olarak tüm hükümetlerin öncelikli hedeflerinden olmasından ötürü; bütçe açıklarının enflasyon üzerindeki etkileri de önem kazanmaktadır.
Bu çalışmada Avrupa’nın yükselen ekonomilerinden Bulgaristan, Hırvatistan, Çekya, Macaristan, Polonya, Romanya, Slovakya ve Slovenya’da bütçe açıklarının enflasyon üzerindeki kısa ve uzun dönem etkileri 1999-2019 dönemi verileri ile panel ARDL yöntemi ile araştırılmaktadır. Bu bağlamda çalışmanın amacı bütçe açıklarının enflasyon üzerindeki kısa ve uzun dönem etkilerini ortaya koymaktır. Panel ARDL yöntemi ile ya-pılan tahmin sonuçlarına göre çalışmanın örneklemini oluşturan ülkelerde bütçe açıkları kısa dönemde azal-tıcı etkide bulunurken, uzun dönemde ise artırıcı niteliktedir.
KİLİT DENETİM KONULARINA ETKİ EDEN FAKTÖRLER: BIST KOBİ ÖRNEĞİ
Authors: VARICI İdris , KALIPÇI ÇAĞIRAN Fevziye 
Published: July 2021

Son yıllarda denetim raporlarına olan güvenin azalması, işletme skandallarının ve denetim şirketlerine açılan davaların artması nedeniyle düzenleyici kuruluşlar harekete geçmiş, denetim raporlarında birtakım yenilikler yapılmıştır. Bu yeniliklerin en önemlilerinden biri kilit denetim konularının bağımsız denetim raporlarında açıklanması gerekliliğidir. Bu gereklilikle birlikte kilit denetim konuları denetim alanında araştırılacak temel konulardan biri haline gelmiştir.
Denetçinin muhakemesi doğrultusunda belirlenmekte olan kilit denetim konuları farklı işletmelerde farklı sayıda raporlanabilmektedir. Bu anlamda açıklanan kilit denetim konusu sayısına etki edebilecek birtakım faktörlerin olduğu düşünülmektedir. Bu çalışmanın amacı denetim raporlarında yer alan kilit denetim konularını nicelik bakımdan etkileyen faktörleri tespit etmektir. Bu amaçla BIST KOBİ Sanayi Endeksinde işlem gören işletmelerin denetim ve finansal raporları analiz edilmiştir. Araştırmanın sonunda açıklanan kilit denetim konusu sayısına denetçi türünün, işletme büyüklüğünün ve likidite açısından cari oranın etki ettiği tespit edilmiştir.
Extraction and Characterization of Collagen from Sand Sea Cucumber (Holothuria scabra)
Authors: Syahputra Gita , Hariyatun Hariyatun , Firdaus Muhammad , Santoso Pugoh 
Published: July 2021

Sand sea cucumber (Holothuria scabra) is an aquatic product that belongs to Echinodermata, a habitant in almost all Indonesian seas. The main component of the sea cucumber is protein, one of which is collagen. This study aimed to extract and characterize collagen from the species using the acid-base extraction method. The characterization of sea cucumber collagen includes molecular weight, amino acid components, Fourier transform infrared spectrophotometry, and scanning electron microscopy analysis. This study has successfully extracted collagen from the sample using an extraction system: NaOH 0.1 M; CH3COOH 0.1 M; and distilled water under 45°C treatments, gave 6% yield. The collagen has a molecular weight 110-130 kDa. Based on the infrared spectra, the specific functional groups of the collagen are amide A (3379.29 cm-1), amide B (2924.09 cm-1), amide I (1681.93 cm-1), amide II (1560.41 cm-1), and amide III (1249.87 cm-1). The collagen falls into type I. We suggest an alternative resource of collagen from sand sea cucumber, other than poultry and mammals.

Keywords: characterization, collagen, extraction, fishery, sand sea cucumber