bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation
Authors: Zhao Chuan-Rong , Yang Fang-Fang , Cui Qinghua , Wang Dong , Zhou Yiran , Li Yi-Shuan , Zhang Yun-Peng , Tang Run-Ze , Yao Wei-Juan , Wang Xiaohong , Pang Wei , Zhao Jia-Nan , Jiang Zhi-Tong , Zhu Juan-Juan , Chien Shu , Zhou Jing 
Published: November 2021

Significance
This work identifies apurinic/apyrimidinic endonuclease1 (APEX1) as a shear stress-sensitive molecule that plays a crucial role in the atherogenic flow-induced endothelial proinflammatory responses. Depletion of endothelial Apex1 in mice ameliorated atherogenesis. We demonstrate that vitexin, a natural flavonoid, can inhibit the activation of APEX1 to protect vascular endothelium against the adverse effects of atherogenic stimuli. Mechanistically, vitexin associates directly with APEX1 to inhibit the atherogenic flow-induced interaction of APEX1 with acetyltransferase p300, its acetylation, and nuclear translocation. The action of APEX1 in the flow-evoked responses is dependent on NF-κB signaling. The translational significance of these findings is that targeting APEX1 with vitexin may represent a potential therapeutic strategy for the treatment endothelial inflammation and the related diseases.
Land and the limits of liberal legalism: property, transitional justice and non-reformist reforms in post-apartheid South Africa
Authors: Evans Matthew 
Published: November 2021

SUMMARY
Critical scholarship on transitional justice, in Africa and globally, has drawn attention both to limits of liberalism and legalism (such as inattention to structural injustices) and to normatively more expansive – transformative, and even revolutionary – approaches to justice. Focusing particularly on South Africa, this debate piece considers the roles of liberal property relations and conceptions of the rule of law in producing and maintaining injustices related to land and property in (post-)transitional societies in Africa and beyond. Moreover, the extent to which transitional justice might contribute to revolutionary aspirations of overcoming capitalist social and economic relations (as espoused, at least rhetorically, by liberation movements throughout Africa) is considered. It is suggested that while this is unlikely, non-reformist reforms offer one avenue by which more expansive (transformative or revolutionary) goals might be pursued, in part, in and through transitional justice.
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation
Authors: Beneke Kira , Pavlidou Nefeli Grammatika , Schäfer Andreas , Nikolaev Viacheslav O. , Molina Cristina E. 
Published: November 2021

Atrial fibrillation (AF) has been linked to the remodeling of membrane receptors and alterations in downstream cAMP-dependent regulation. However, to date, no study has elucidated how the increase on cAMP upon different G-protein-coupled receptors (GPCRs) can lead to different physiological compartmentalized responses. The aim of this study was to investigate the compartmentally specific effects of GPCRs on cAMP levels in human atrial myocytes (HAMs) from patients with AF and control patients without AF (Ctl), and how these compartmentalized effects are altered in AF. HAMs were isolated from 60 AF and 76 Ctl patient tissues. Cells were transduced with adenoviruses (Epac1-camps, pm-Epac1-camps and Epac1-JNC) and cultured for 48 hours to express the FRET-based cAMP sensor in the cytosolic, membrane, and RYR2 nanodomains. Förster-resonance energy transfer (FRET) was used to measure cAMP levels in 525 HAMs stimulated with isoprenaline (100 µM), serotonin (100 µM), or the A2AR agonist CGS (200 nM). A desensitization to β-adrenergic receptor stimulation was exclusively found in the cytosol of AF myocytes, while no difference was seen in the RYR2 or LTCC compartment. Similar effects were observed upon serotonin stimulation with a significant desensitization in the cytosol, and no difference in the RYR2 compartment. In response to A2ARs stimulation AF myocytes displayed a significantly higher cytosolic increase in cAMP levels. However, no response was seen in the LTCC compartment in response to serotonin or A2AR stimulation. Collectively, our data show that cAMP levels are highly compartmentalized and differentially regulated by GPCRs. Furthermore, these results provide a mechanistic insight for the previously reported functional effects seen upon stimulation of these three receptors.
A hollow microlattice based ultralight active thermal control device and its fabrication techniques and thermal performances
Authors: Xu Wenjun , Liu Longquan , Chen Junming , Lv Xinying , Yao Yongtao 
Published: November 2021

Abstract
This paper introduces a new thermal control device (TCD) which has not only low weight and high efficiency but also passive and active cooling capabilities. The TCD mainly consists of hollow graphene-enhanced-metallic microlattice material, phase change material (PCM) and a peristatic pump. The PCM is inside the spatial-interconnected millimeter-scale diameter tubes, which are the basic constitution of the hollow microlattice material, in addition, the peristatic pump was connected with the tubes and used to force the liquid-state PCM to circulate inside the interconnected thin tubes. Thus, the proposed TCD takes combined advantages of the ultralight and high thermal transfer properties of the hollow graphene-enhanced-metallic microlattice materials, the thermal storage capability of the PCM and forced convection of the PCM driven by the peristatic pump as the PCM is in liquid state. The manufacturing process of the active TCD was also developed and proposed, which mainly includes additive manufacturing, composite electroless plating, polymer etching, liquid PCM injecting and the peristatic pump connecting. In addition to that, a thermal test system was built and the effective thermal conductivities of the TCD in passive cooling and with active cooling modes were experimentally studied. The TCD can absorb heat and actively dissipate heat by means of forced convection. Consequently, the proposed active TCD can be used to guarantee the electronic components and spacecrafts operate in a specific temperature range.
Electron beam-plasma discharge in GDT mirror trap: experiments on plasma start-up with electron gun
Authors: Soldatkina E.I. , Pinzhenin E.I. , Korobeynikova O.A. , Maximov V.V. , Yakovlev D.V. , Solomakhin A.L. , Savkin V.Ya. , Kolesnichenko K.S. , Ivanov A.A. , Trunev Yu.A. , Voskoboynikov R.V. , Shulzhenko G.I. , Annenkov V.V. , Volchok E.P. , Timofeev I.V. , Bagryansky P.A. 
Published: November 2021

Abstract
The paper describes experiments on the injection of an electron beam into a gas at the gas dynamic trap (GDT) and develops a technique for creating a starting plasma with parameters sufficient for its subsequent heating by neutral beams. It is found that a relatively thin electron beam is capable of ionizing plasma in the entire volume of the trap, and the plasma turbulence it excites is capable of accelerating some of the electrons to energies tens of times higher than the initial energy of the beam. It is shown that, in contrast to early experiments on tabletop open traps, collective beam relaxation under GDT conditions occurs in the vicinity of the entrance magnetic mirror. Since the electron cyclotron frequency in this region significantly exceeds the plasma frequency, it is necessary to study the mechanism of a beam-plasma discharge under these conditions. As a first step along this path, we measure the radial diffusion coefficient of fast particles, as well as the rate at which they gain energy.
Identifying the microtearing modes in the pedestal of DIII-D H-modes using gyrokinetic simulations
Authors: Hassan Ehab , Hatch D.R. , Halfmoon M.R. , Curie M. , Kotchenreuther M.T. , Mahajan S.M. , Merlo G. , Groebner R.J. , Nelson A.O. , Diallo A. 
Published: November 2021

AbstractRecent evidence points toward the microtearing mode (MTM) as an important fluctuation in the H-mode pedestal for anomalous electron heat transport. A study of the instabilities in the pedestal region carried out using gyrokinetic simulations to model an ELMy H-mode DIII-D discharge (USN configuration, 1.4 MA plasma current, and 3 MW heating power) is presented. The simulations produce MTMs, identified by predominantly electromagnetic heat flux, small particle flux, and a substantial degree of tearing parity. The magnetic spectrogram from Mirnov coils exhibits three distinct frequency bands—two narrow bands at lower frequency (∼35–55 kHz and ∼70–105 kHz) and a broader band at higher frequency (∼300–500 kHz). Global linear GENE simulations produce MTMs that are centered at the peak of theω*profile and correspond closely with the bands in the spectrogram. The three distinctive frequency bands can be understood from the basic physical mechanisms underlying the instabilities. For example (i) instability of certain toroidal mode numbers (n) is controlled by the alignment of their rational surfaces with the peak in theω* profile, and (ii) MTM instabilities in the lowernbands are the conventional collisional slab MTM, whereas the highernband depends on curvature drive. While many features of the modes can be captured with the local approximation, a global treatment is necessary to quantitatively reproduce the detailed band gaps of the low-nfluctuations. Notably, the transport signatures of the MTM are consistent with careful edge modeling by SOLPS.
Overview of the Load-source Duality Modeling for Demand Side
Authors: Wang Xueying , Xue Yawei , Peng Dong , Zhao Lang , Liu Hongyang , Li Yizheng , Zhang Tianqi 
Published: November 2021

Abstract
With the increase of load and clean-green energy connect to the power system, big challenges are brought to the traditional control method of generation-follows-load (GFL). Therefore, it is important to study the load-follows-generation (LFG) models which can achieve active demand response by changing the load temporarily to reduce the difference between maximum and minimum load. This paper introduces the concept of LFG and GFL models, summarizes the difference between them and puts forward the concept of load-source duality at first. Then, introduces load response modeling, optimization objectives, constraints, scheduling methods and control methods of six LFG models based on the recent research results in this area. Each model can alleviate the pressure in maintaining stability on the generation side, improving the safety and reliability of the power system. Finally, this paper puts forward the future development trend of LFG models based on the overviews.
Single-phase-to-ground Fault Line Selection Method Based on STOA-SVM
Authors: Liu Yicen , Liu Xiaojiang , Fan Songhai , Ma Xiaomin , Deng Sijing 
Published: November 2021

Abstract
In view of the complex characteristics of nonlinearity and non-stableness of the zero-order current of each line after the single-phase ground fault of the distribution network, a distribution network fault selection method based on Sooty Tern Optimization Algorithm(STOA) and the combination of support vector machine is proposed. At first, the zero-sequence current before and after fault is obtained, then five kinds of IMFs including different components are obtained by ensemble empirical mode decomposition, and the energy entropy of the fault transient zero-sequence current is obtained by Hilbert transform, the results of training and testing are obtained by inputting the feature vector. The simulation results show that the accuracy of the proposed line selection model is 97.5%.
Improved UKF-SLAM with Lie Group Operation and Robust Feature Tracking for Motion Vehicles
Authors: Huang Xin , Liang Zuoxian , Zhang Kai , Liu Pingyuan 
Published: November 2021

Abstract
This paper proposes an improved simultaneous localization and mapping (SLAM) algorithm based on tightly coupled camera images and IMU data, which provides accurate and robust localization for autonomous vehicles and unmanned aerial vehicles (UAV), especially for those in GPS-denied environments. Many research efforts have demonstrated the effectiveness of fusing camera images and inertial data with the Unscented Kalman filter (UKF), but there is still one tricky problem about the non-linearity of the kinematics of rotations. To address this issue, we propose a novel UKF-SLAM approach by rebuilding system and measurement models based on the Lie group and Lie algebra, which obtains state estimates with reasonably high accuracy. Besides, we also offer a new method to handle corner matching outliers, which only causes slightly additional computation costs but eliminates outliers and enhances corner tracking robustness. Results from extensive experimental data have validated the effectiveness of the proposed approach, and this method also achieves comparable precision to the state-of-art.
Research on Intelligent Control System Based on Feature Recognition
Authors: Wu Jinghong , Liu Qian , Chen Jian 
Published: November 2021

Abstract
Fountain is an important facility in modern landscape art. Ordinary fountains are regulated by water valves, which makes the water column of the fountain very high, so the height of the fountain cannot be changed flexibly, the fountain is the product of the combination of the most popular garden architecture and appreciation in recent years. In this paper, intelligent control system based on feature recognition is designed. According to the system, fountain forms and features can be recognized automatically. At the same time, the system can also be integrated with computer animation, which makes the melody, emotion, rhythm and waterscape art to realize harmonious and unified.
Research on Aging Resistance of Three Phase Composites for Anti-collision Intelligent Control of Bridge Engineering
Authors: Wang Jifeng , Guan Liangchao , Ge Jing 
Published: November 2021

Abstract
Aminated Carbon Nanotubes (CNTs) and Carbon Fiber (CF) materials for anticollision intelligent control of Bridge Engineering were used to enhance the properties of Bismaleimide Resin (BMI) matrix resin and then tested the moist heat aging, salt spray aging and erosion resistance in this study. The resulted show that when the aging time was 168h, after wet heat and salt spray, the flexural strength and impact strength of three-phase composites with 1.5wt% MWNTs-NH2 content can reach maximum, and the wet heat aging bending performance is 45% better than that of non-added carbon nanotubes, the impact performance is 41% higher, the salt spray aging bending performance is 43% higher and the salt spray aging impact performance is 32% higher.
Design of Automatic Controller System for Three Axis 3D Printing Platform
Authors: Ren Hongwei , Luan Yongchao , Dong Xingkun , Zhou Haijun , Chen Xin , Yu Xiaochuan 
Published: November 2021

Abstract
With the development of society and the continuous improvement of the level of automation, automatic three-dimensional work platform is more and more popular, but now the three-dimensional work platform has a single function, and the waste of capacity is a serious problem. Therefore, this paper uses STM32F429 MCU to design a set of replaceable working position of the three axis control platform. The design of the table with replaceable work head, by identifying the ID on the head, change the control mode, enhance the functional diversity of the three-axis platform. In addition, in order to improve the universality of the system, the platform has many external communication interfaces, visual man-machine interface and LAN network communication functions.
Design of On-line Detecting Device for Groove Wear of Elevator Traction Wheel
Authors: Shi Xiaomin , Jia Senjun 
Published: November 2021

Abstract
After the wear of elevator traction wheel, there is a traditional detection method which can measure the geometric dimensions of wheel groove. But this method has low measurement accuracy and cannot accurately reflect the actual profile of wheel groove. By means of the machine vision inspection technology, the profile of the traction wheel groove can be measured, a new detection method is proposed in this paper, and the corresponding measuring device is designed in detail. At the same time, with help of the computer simulation, the processing of the work piece image is used. In this method, the size and profile of the wheel groove of the traction wheel can be measured more accurately and quickly to reflect the actual wear value of the wheel groove.
An Improved Artificial Potential Field Escape Method with Weight Adjustment
Authors: Wang Hongyun , Gao Min , Gao Weiwei , Wang Yi , Zhou Haijun 
Published: November 2021

Abstract
Aiming at the problems of obstacle avoidance and bullet avoidance during the patrol swarm, this paper analyzed the defects of the classical artificial potential field, proposed an adjustable escape method, which establish the relationship between the adjustment coefficient and the distance. This method avoid too large or too small escape force that get the bullet into new local shock problem near the target. Then given the weight calculation and parameter selection method, restricted the escape motion by kinematics according to the constraints in the actual motion. This improved method can effecting solve the problem of avoidance in dynamic and complex environment.
Propagation Characteristics of Pressure Pulsation in Hydraulic Hose
Authors: Meng Yuzhen , Han Lei , Zhao Wenkui , Zhang Lishan 
Published: November 2021

Abstract
Most modern aircraft hydraulic systems use variable plunger pumps. The pulsating flow output is its inherent characteristic. The resulting pressure pulsation often causes serious damage to the energy pipeline system and endangers the lives of the occupants. This paper studies the propagation law of hydraulic oil in hydraulic hoses, fully considers the coupling vibration of hydraulic oil high-pressure fluid and flexible solids of the hose, establishes a fluid-solid coupling vibration model of hydraulic hoses, and uses ANSYS for numerical simulation to study different frequencies and pipe bending. Using ANSYS for numerical simulation to study the influence of different frequencies and pipe bending radii on the amplitude of fluid pressure pulsation, after comparative analysis, the law of fluid pressure pulsation propagation in hydraulic hoses is obtained.
Numerical Simulation of Temporal and Spatial Evolution of Stress Field in Unconsolidated Sandstone Oil Reservoir
Authors: Pei Guihong , Song Jiecheng , Zhang Xiaolong 
Published: November 2021

Abstract
Casing damage in the process of oilfield development is a serious problem, which is affected by geological structure, production technology and many other factors. To prevent casing damage, it is necessary to master the space-time evolution law of reservoir in-situ stress field, to provide support for casing damage prevention. Based on the perseage-stress coupling theory, taking the actual reservoir block as the research object, the change law of the in-situ stress field in unconsolidated sandstone reservoir is obtained through the fluid-solid coupling numerical simulation of the reservoir, and the internal correlation between the stress field and casing damage is analysed. The research results provide theoretical guidance for the formulation of casing damage prevention measures in the research block.
Characterization of Silicon-Photomultipliers for a Cosmic Muon Veto detector
Authors: Jangra M. , Majumder G. , Saraf M. , Satyanarayana B. , Shinde R.R. , Upadhya S.S. , Datar V.M. , Glenzinski D.A. , Bross A. , Pla-Dalmau A. , Zutshi V.V. , Group R.C. , Dukes E.C. 
Published: November 2021

Abstract
A Cosmic Muon Veto (CMV) detector using extruded scintillators is being designed around the mini-Iron Calorimeter detector at the transit campus of the India-based Neutrino Observatory, Madurai for measuring its efficiency at shallow depth underground experiments. The scintillation signal is transmitted through a Wavelength Shifting (WLS) fibre and readout by Hamamatsu Silicon-Photomultipliers (SiPMs). A Light Emitting Diode (LED) system is included on the front-end readout for in-situ calibration of the gain of each SiPM. A characterization system was developed for the measurement of gain and choice of the overvoltage (V
ov) of SiPMs using the LED as well as a cosmic muon telescope. The V
ov is obtained by studying the noise rate, the gain of the SiPM, and the muon detection efficiency. In case of any malfunction of the LED system during the operation, the SiPM can also be calibrated with the noise data as well as using radioactive sources. This paper describes the basic characteristics of the SiPM and the comparison of the calibration results using all three methods, as well as the V
ov of the SiPMs and muon selection criteria for the veto detector.
Isotopic evidence of increasing water abundance and lake hydrological change in Old Crow Flats, Yukon, Canada
Authors: MacDonald Lauren A , Turner Kevin W , McDonald Ian , Kay Mitchell L , Hall Roland I , Wolfe Brent B 
Published: November 2021

Abstract
Lake-rich northern permafrost landscapes are sensitive to changing climate conditions, but ability to track real-time and potentially multiple hydrological responses (e.g. lake expansion, drawdown, drainage) is challenging due to absence of long-term, sustainable monitoring programs in these remote locations. Old Crow Flats (OCF), Yukon, is a Ramsar Wetland of International Importance where concerns about low water levels and their consequences for wildlife habitat and traditional ways of life prompted multidisciplinary studies during the International Polar Year (2007–2008) and led to the establishment of an aquatic ecosystem monitoring program. Here, we report water isotope data from 14 representative thermokarst lakes in OCF, the foundation of the monitoring program, and time-series of derived metrics including the isotope composition of input waters and evaporation-to-inflow ratios for a 13 year period (2007–2019). Although the lakes spanned multiple hydrological categories (i.e. rainfall-, snowmelt- and evaporation-dominated) based on initial surveys, well-defined trends from application of generalized additive models and meteorological records reveal that lakes have become increasingly influenced by rainfall, and potentially waters from thawing permafrost. These sources of input have led to more positive lake water balances. Given the documented role of rainfall in causing thermokarst lake drainage events in OCF and elsewhere, we anticipate increased vulnerability of lateral water export from OCF. This study demonstrates the value of long-term isotope-based monitoring programs for identifying hydrological consequences of climate change in lake-rich permafrost landscapes.
Modelling and Analysis of a Virtual Prototype of a Rotary Machine in MSC.ADAMS
Authors: Sapietová A , Dekýš V , Sapieta M , Jastraban A , Pástor M 
Published: November 2021

Abstract
The article presents an analysis of the virtual model of Laval (Jeffcott) rotor in the software environment MSC.ADAMS. The parameters describing the stability of the rotor operation were monitored and evaluated, i. j. critical angular velocity and trajectory of the rotor center of gravity (orbit). The results were compared with the values measured on the experimental equipment, as well as with the values obtained by analytical calculation. The paper further presents a simulation in which the second critical velocity was reached. The paper further presents a simulation in which the second critical velocity was reached.