bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela
Authors: Nakhjiri Elnaz , Roqanian Shaqayeq , Zangbar Hamid Soltani , Vafaee Manuchehr Seyedi , Mohammadnejad Daryoush , Ahmadian Shahin , Zamanzadeh Selva , Ehsani Ehsan , Shahabi Parviz , Shahpasand koorosh 
Published: September 2021

Abstract
Spinal cord injury (SCI) can lead to neurological impairment with significant functional and cognitive deficits. It is obvious that SCI causes focal neurodegeneration that gradually expands to the other cord areas. On the other hand, it is clear that traumatic brain injuries result in tau protein pathology and profound neurodegeneration. Tau is a microtubule-associated protein, which is highly expressed in neurons, and its abnormalities result in neuronal cell death. Moreover, it is clear that tau pathology spreads in various brain areas upon trauma. Therefore, we herein examined tau pathology in the spinal cord as well as brain samples at various time-points in severe SCI mouse models. We examined the effects of severe SCI on locomotor function, spatial memory, and anxiety/risk-taking behavior. We found a gradual increased tau pathology in the spinal cord as well as brain areas; confirmed by immunostaining and immunoblotting. Moreover, we studied the brain samples with electron microscopy and observed disrupted mitochondria and microtubule structure upon SCI. SCI caused motor dysfunction, memory impairment, and abnormal risk-taking behavior. Importantly, pathogenic cis P-tau elimination with systemic administration of respective monoclonal antibody restored SCI-related pathological and functional consequences. Thus, our finding suggests that SCI results in profound tauopathy, which spreads to brain areas, reflecting brain dysfunction. Moreover, tau immunotherapy with anti-cis P-tau antibody could suppress the pathogenic outcomes in the SCI mouse models, which would have profound clinical implications in the SCI patients.
Strategic alliances for sustainable development: An application of DEA and Grey Theory Models
Authors: Wang Chia-Nan , Nguyen Hoang-Phu , Nhieu Nhat-Luong 
Published: September 2021

Abstract
Sustainable development is a global trend and an economic priority for many nations. Although new energies can be considered good investments in green growth, it may lead to financial barriers to developing countries. The purpose of the study concentrates on an alternative solution that increasing the efficiency performance of current fossil energy industries. The study has combined two models of Data Envelopment Analysis (DEA) and Grey Theory in determining inefficiency units and proposed potential strategic alliances for sustainable development in the Vietnam Coal industry. Besides considering inputs and outputs in the models, the location of coal mines is also a key indicator in recommending good alliances. The results show that the collaborations between Cao Son coal mine and Coc Sau coal mine; between Nui Beo coal mine and Vang Danh coal mine brings the best improvement for sustainable development. The study suggests detailed strategies in action that enterprises and policymakers can refer to apply in practice.
Optimization of a Heliostat Field by Multiobjective Particle Swarm Optimization (MOPSO) Algorithm Based on Energy, Exergy, and Economic Point of Views
Authors: Zhang Huijuan , Bayati Morteza , Ehyaei M. A. , Ahmadi A. , Costa V. A. F. 
Published: September 2021

Abstract
This research is devoted to the energy, exergy, and economic analyses and optimization of a heliostat field. The model of the heliostat solar receiver includes detailed geometric factors related to the optical and thermal losses and efficiencies throughout the year. The main parameters of the thermal performance of this system consist of energy and exergy efficiencies, and economic parameters are investigated. By computing the energy, exergy, and economic analysis tools, they are applied for the analysis of performance, and viability of the system’s operating in Tehran City, including the detailed information of the environmental conditions of that location. For optimization purposes, 7 design variables related to geometric specification of the heliostat field are selected and the related lower and upper bonds are selected. Two target functions considered for the optimization are heliostat field exergy efficiency and payback period. The economic feasibility results of this study reveal that the net present value is 58.84 million US$, the payback period is 6.76 years, and the internal rate of return is 0.16. By considering the MOPSO algorithml, the annual mean exergy efficiency is increased from the 30.9–34.3% while the heliostat field payback period in reduced from the 6.76 to 4.3 years.
Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxic Effect via SLC7A11-Mediated Redox Collapse
Authors: Chen Hui , Zhang Han , Cao Lixing , Cui Jinling , Ma Xuan , Zhao Chong , Yin Shutao , Hu Hongbo 
Published: September 2021

Abstract
Background: Combination of fasting with chemotherapy has been drawn an increasing attention because of the encouraging efficacy. SLC7A11 is frequently over-expressed in most of cancer cells, and elevated expression of SLC7A11 renders cancer cells more susceptible to glucose starvation owing to SLC7A11-mediated redox collapse. Selenite is a representative inorganic form of selenium, and is preferentially accumulated in tumors. This selenophilic peculiarity of cancer cells is closely associated with the elevated expression of SLC7A11. Given the established the link among glucose deprivation, SLC7A11, oxidative stress and selenite, we hypothesized that glucose starvation could specifically sensitize cancer cells to selenite-mediated cytotoxic effect. Methods: The cytotoxic effect of combining selenite with glucose starvation on cancer cell was assessed by crystal violet staining and Annexin V/PI staining. Flow cytometry were employed to assess intracellular ROS levels, labile iron pool and lipid peroxidation. Xenograft models were used to test its in vivo antitumor activity. Commercial assay kit, LC-MS, RNA interference and western blot were applied to investigate the mechanism underlying synergistic effect.Results: It showed that cytotoxic effect of selenite on cancer cells, but not on normal cells, was significantly enhanced in response to the combination of selenite and glucose limitation. Furthermore, in vivo therapeutic efficacy of combining selenite with fasting was dramatically improved in xenograft models of lung and colon cancer. Mechanistically, we found that SLC7A11 expression in cancer cells was up-regulated by selenite both in vitro and in vivo. The elevated SLC7A11 led to accumulation of cystine, depletion of NADPH, and inhibition of cystine to cysteine conversion, which in turn boosted selenite-mediated reactive oxygen species (ROS), followed by enhancement of selenite-mediated cytotoxic effect. Conclusion: The findings of the present study provide an effective and practical approach for increasing the therapeutic window of selenite, and imply that combination of selenite with fasting holds promising potential to be developed a clinically useful regimen for treating certain types of cancer.
Prevalence and associated factors of Female genital mutilation among reproductive age women’s of Wolayita Zone, Southern Ethiopia: a cross-sectional study, 2018
Authors: Anjulo Bargude Balta , Lambebo Amanuel Fanta 
Published: September 2021

Abstract
Background

Female genital mutilation (FGM) is estimated to have been practiced on at least 200 million girls and women in 30 countries around the world. Clitoridoctomy is the most common type of FGM in Ethiopia.
Objectives

The aim of the study was to assess the magnitude of Female Genital Mutilation and associated factors among women’s of Wolayita zone.
Methods

A community-based quantitative cross-sectional study was used. Face-to-face interviews with prepared questionnaires were used to collect data. SPSS version 20 software was used to analyze the data. The prevalence of FGM was determined using descriptive statistics. The researchers utilized a bivariate and multivariate logistic regression model to find independent determinants of FGM.
Result

296 women were circumcised out of a total of 333, indicating that FGM is prevalent in the research area (88.9%). age (AOR-1.86, 95% CI: 0.42–0.98) and support for tradition (AOR: 14.595, 95% CI: 3.391–6.807) were all independently linked to FGM.
Conclusion

An integrated effort administrative and surrounding community intervention to be initiated to alleviate FGM practices through empowering women, discouraging risky factors like traditions; and sensitizing parents, community members and the public focusing on the rejecting of FGM.
Biomolecular Characterization of Bacillus tequilensis A1C1 Isolated from Soil and Chromatographic Analysis of D-serine in its Cellular Fraction
Authors: Kapil Shikha , Bhattu Monika , Kumar Tarun , Sharma Vipasha 
Published: September 2021

Abstract
The bacteria isolated from the pomace dumping soil site (bacteria id A1C1) showed maximum growth (O.D600 = 1.97 ± 0.4 X 109 cells/ml) within 48h in the minimal salt media supplemented with L-serine. The isolated strain was identified as ‘Bacillus tequilensis’ through 16sRNA sequencing. The strain was quantified for D-serine content by using RP-HPLC. The D-serine concentration was calculated as 0.919 ± 0.02 nM in the bacterial cellular fraction by using a standard curve plot and linear curve equation. Further, recovery % was also calculated for the spiked samples which vary from 85–90%. The study’s peculiarity reflects the fact that the isolated strain was explored for the first time to detect the presence of serine enantiomers. The biochemical features also showed 70% similarity to the standard strain Bacillus tequilensis 10bT. The optimum growth parameters were recorded as 37℃±0.5, 150 ± 0.5 RPM, and 7 ± 0.5pH. The strain was Gram-positive and synthesized endospores. Morphological results showed its rod shape, large, irregular, and off-white-coloured colonies. A1C1 was also tested for the production of secondary metabolites and enzymes. A1C1 showed positive results for indole production, lactose fermentation, protease, and gelatinase whereas, negative results for catalase, MR-VP, citrate utilization, cellulase, amylase, and pectinase. Further, the strain was assayed for PGPR attributes and showed a negative phosphate solubilization index and IAA production. The antibacterial assay showed 5% and 2% efficacy of the extracellular fraction against MTCC 40 and MTCC 11949 respectively. These results demonstrate that Bacillus tequilensis A1C1 has antibacterial activity, the potential to secrete extracellular enzymes, and D-serine content in the intracellular fraction of the cultivated cells.
To study the in-vivo efficacy and safety of AYUSH polyherbal formulation among COVID-19 infected Syrian gold hamsters
Authors: Kanchibhotla Divya , Subramanian Saumya , K.R. Hari Venkatesh , reddy Ravi 
Published: September 2021

Abstract
The COVID-19 pandemic has infected millions of people around the world and the resulting disease burden has challenged the already stressed healthcare systems globally. Amidst the increasing morbidity rate of SARS-CoV-2, the scientific community is vigorously researching possible remedies targeted against the virus. Natural herbs have a great potency to cure infectious diseases and are vastly unexplored. The present study aims to investigate Ayurvedic herbs in a unique polyherbal formulation, NOQ19, against the SARS-CoV-2 virus in an animal model. A total of 19 female Syrian hamsters were infected with the virus cell culture through intranasal route. 4 out of 19 animals were mock controls, 5 were infection controls, 4 were treated with remdesivir and acted as positive controls and remaining 6 were treated with NOQ19. The hamsters were observed to note body weight reduction and adverse events followed by sacrifice on day 4 after inoculation with the virus. The lung pathology and viral load was studied in each hamster. Results showed a significant reduction of 78.2% in the viral load for the NOQ19 arm, as compared to the infection control. Gross examination of the lung histology of the NOQ19 arm suggested an improvement in edema and congestion compared to the infection control. Also, no adverse events were noticed in NOQ19 hamster group. Therefore, the authors propose NOQ19 formulation as a potential option to be tested further for its efficacy and efficiency against COVID-19.
Ranking of barriers for the internet of things implementation in the E-learning platform
Authors: Yadav Vinay Kumar , Yadav Sanjeev 
Published: September 2021

Abstract
Learning through the Web or training via e-learning is rising exponentially and is gradually preferred by conventional ways of education and training. This massive change is directly related to digital computer technological advancement. The transformation driven by innovation in computer technology has enhanced the reach of e-learning and education, making the process of sharing knowledge easy, clear, and efficient. The E-learning system relies on various success factors from several viewpoints, such as framework, organisational alignment, instructor, and student support. This paper aims to identify the critical barriers to the Internet of Thing implementation in e-learning and to establish a relational relationship between identified barriers using the Interpretive Structural Modelling approach. This paper has established some primary barriers that are useful for Internet of Things implementation in E-learning by research scholars and industrial practitioners. For the study of the driving force and dependency power of the E-learning barrier, Interpretive Structural Modelling methodology was used to classify interrelationships between barriers for improved understanding and relationships between these barriers, and Management Cross Impact Multiplications were conducted to estimate the magnitude of these relationships. Applied to classification analysis, which is used for analysing the driving power and dependence power of E-learning barriers.
Individualized Clinical Target Volume Delineation and Efficacy Analysis in Unilateral Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy (IMRT): 10-Year Summary and Results
Authors: Xie De-Huan , Wu Zheng , Li Wang-Zhong , Cheng Wan-Qin , Tao Ya-Lan , Wang Lei , Lv Shao-Wen , Lin Fei-Fei , Cui Nian-Ji , Zhao Chong , Ma Jun , Huang Shao-Min , Lu Tai-Xiang , Su Yong , Han Ya-Qian 
Published: September 2021

Abstract
Purpose: To evaluate the long-term local control, failure patterns, and toxicities after individualized clinical target volume (CTV) delineation in unilateral nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).Methods: Unilateral NPC was defined as nasopharyngeal mass confined to one side of nasopharynx and did not significantly exceed the midline of nasopharyngeal apex/posterior wall. From November 2003 to December 2017, 95 patients with long-term follow-up were retrospectively included. All patients received IMRT. The CTVs were determined based on the distance from the gross tumor, the contralateral parapharyngeal space and skull base orifices were spared from irradiation.Results: There were 3 local recurrence and 8 regional recurrences in 10 patients during 84- month follow-up. All local recurrences were PGTVnx-in-field, and no recurrences in traditional high-risk area including contralateral parapharyngeal space and skull base orifices. The 10-year local-recurrence free survival, regional-recurrence free survival and overall survival were 96.2%, 90.5% and 84.7%, respectively. The dosimetry parameters of the tumor-contralateral organs were all lower than the values of the tumor-ipsilateral side (P < 0.05). The late toxicities occurred mainly in the tumor-ipsilateral organs, including radiation-induced temporal lobe injury, impaired visuality, hearing loss and subcutaneous fibrosis.Conclusion: Individualized CTV delineation in unilateral NPC could yield excellent long-term local control with limited out-of-field recurrences, reduced dose to tumor- contralateral organs and mild late toxicities, which is worthy of further exploration.
Adsorption-regulated precise synthesis of atomically-dispersed bimetallic Fe-Co sites on carbon for electrocatalytic nitrogen reduction reaction
Authors: Zhang Shengbo , Han Miaomiao , Shi Tongfei , Zhang Haimin , Lin Yue , Zheng Xu-Sheng , Zheng Li Rong , Zhou Hongjian , Chen Chun , Zhang Yunxia , Wang Guozhong , Yin Huajie , Meng Guowen , Zhao Huijun 
Published: September 2021

Abstract
The intriguing features of single-atom catalysts (SACs) could bring catalysis into a new paradigm, however, controllably synthesising SACs with desired SA loadings and coordination forms are challenging. Here, we report an adsorption-regulated approach to precisely control the synthesis of bimetallic Fe-Co SAs on carbon. Bacterial cellulose (BC) is utilised as an adsorption regulator to controllably impregnate Fe3+/Co2+ on BC and through carbonisation to anchor Fe-Co SAs on BC-derived carbon via bimetallic [(O-C2)3Fe-Co(O-C2)3] coordination with desired Fe/Co contents and atomic ratios. Under electrocatalytic nitrogen reduction reaction (NRR) conditions, [(O-C2)3Fe-Co(O-C2)3] is operando transformed to [(O-C2)3Fe-Co(O-C)C2] that promotes and sustains NRR performance. A superb ammonia yield of 574.8 ± 35.3 μg h-1 mgcat.-1 with an exceptional faradaic efficiency of 73.2 ± 4.6% are obtained from an electrocatalyst with the highest bimetallic Fe-Co site density. The exemplified synthetic approach would be of generically applicable to controllably anchor SAs on carbon that enables meaningfully investigate and rationally design SACs.
Revealing the scientific root of scratch formation on soda-lime-silica glass surface: Digging deeper into structural modification of glass surface
Authors: Roy Barsheek , Rosin Andreas , Gerdes Thorsten , Schafföner Stefan 
Published: September 2021

Abstract
Scratch formation on glass surfaces is a ubiquitous phenomenon induced by the virtue of plastic deformation, often accompanied by radial, lateral or median cracks with consequent chipping and brittle fracture caused during and after the event of dynamic abrasion instigated by shear stress by another harder material. This paper deals with the fundamental aspect of scratch formation on soda-lime-silica (SLS) glass surfaces. A constructive combination of surface-sensitive characterization tools including field emission scanning electron microscopy (FESEM), laser scanning microscopy (LSM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and instrumented indentation technique (IIT), helped to investigate the structural cause of generation of visible scratches on SLS glass surfaces. The experimental evidences propose that a silicate network possessing a mechanically-weakening structural characteristic in terms of network connectivity confined to the region between 5 nm and 100 nm below the glass surface, is likely to cause a destructive surface scratch eminently visible to naked eyes.
Sonographic Measurement and Sex Variability of Portal Vein Using US scan in a sample of Sudanese Adults
Authors:   Mohammedelghazali Abuelgassim Elbagir Mustafa1, Mustafa Elbagir , Abdulkarim Mohamed , Awad Khalid A. , Koko Alaa Osman Mohamed 
Published: September 2021

Abstract

Background: Measurements of the normal portal venous dimension in a specified population is so crucial. portal vein can be measured by several methods for assessing different parameters, Computed topography (CT) and sonographic imaging are common examples. The diagnosis of portal hypertension depends on the transverse portal vein diameter (normal diameter from 6-15 mm). The aim of this study is to establish baseline value for the portal vein diameter and assess the correlation with age, gender, weight, height and BMI in Sudanese populations.Methodology: This was a descriptive cross-sectional study that included a sample of Sudanese adults who were requested to have routine abdominal sonographic scanning due to reasons not related to liver or portal vein problems. The study was carried out at the Radiology Department of Qatar Alnada Hospital, Umbadda, Khartoum, Sudan 2020.Results: In this study, 376 participants were included of which more than half were females (56.1%, n=211), while 165(43.9%) were males. The mean age of the participants was 38.12 + 15.57 years. The mean portal vein diameter was 10.79 + 1.27 millimeters. From this study the portal vein diameter varied with age (p value = 0.000), weight (p value = 0.002), height (p value = 0.000) and gender (p value = 0.000). It is not related to BMI (p value = 0.3).Conclusion: This study has revealed that the portal vein diameter has positive correlation with age, gender, height, and weight of the person and has no correlation with the BMI.
Achievements, challenges and opportunities of rainwater harvesting in the Ethiopia context: a review
Authors: Roba Negash Tessema , Kassa Asfaw Kebede , Geleta Dame Yadeta , Hishe Birhanu Kindshih 
Published: September 2021

Abstract
Rainwater harvesting (RWH) is a novel way for developing countries to construct and maintain long-term water supply systems. As a result, this review paper draws on actual findings and lessons learned from various places in Ethiopia to assess the country's achievements and opportunities when it comes to RWH, as well as to guide future alternatives toward its sustainability. RWH acts as to help throughout the rainy season's dry spells, as a potential asset for the dry season, aiding human and livestock consumption as well as crop production through irrigation. So, for successful well-organized rain water collection, watershed treatment, seepage and evaporation control, soil and water conservation, conservation tillage, and integration of low-cost water lifting techniques and family drip systems should all be undertaken. Given that the country has not been significantly modernized, it has outdated experience in the operation and exploitation of RWH systems. Aside from financial inadequacies, historical and political instability, lack of understanding among farmers, and resistance to new technologies, the country has opportunities and has made some progress on RWH systems. In general, RWH could enable smallholder farmers to diversify their crops, thereby enhancing household food security, dietary status, and economic return. In addition, the much-needed green revolution and climate change adaptations should combine RWH ideas with agronomic principles in the country. More work is needed to strengthen indigenous practices and share best practices to a larger scale.