bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Insights in Coagulation and Fibrinolysis in Patients with Primary Brain Cancer: A Systematic Review
Authors: Winther-Larsen Anne , Sandfeld-Paulsen Birgitte , Hvas Anne-Mette 
Published: October 2021

AbstractPatients with primary brain tumors have a high incidence of thrombosis and hemorrhage. The underlying mechanism is believed to be derangement of their hemostatic system. To get nearer a clarification of this, we aimed to systematically review the existing literature regarding primary and secondary hemostasis as well as fibrinolysis in patients with primary brain tumor. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases PubMed, Embase, and Web of Science were searched on December 15, 2020, without time restrictions. Studies were included if they evaluated at least one blood coagulation and/or fibrinolysis parameter in patients with primary brain cancer. In total, 26 articles including 3,288 patients were included. Overall, increased activity of secondary hemostasis was observed as increased prothrombin fragment 1 + 2 and endogenous thrombin generation levels were found in glioma patients compared with controls. Furthermore, data showed a state of hypofibrinolysis with increased plasminogen activator inhibitor 1 and prolonged clot lysis time in glioma patients. In contrast, no consistent increase in the primary hemostasis was identified; however, data suggested that increased sP-selectin could be a biomarker of increased venous thromboembolism risk and that increased platelet count may be prognostic for survival. Lastly, data indicated that fibrinogen and D-dimer could hold prognostic value. In conclusion, this review indicates that an increased activity of secondary hemostasis and impaired fibrinolysis could be important players in the pathogeneses behind the high risk of thromboembolisms observed in brain cancer patients. Thus, long-term thromboprophylaxis may be beneficial and additional studies addressing this issue are wanted.
Salvage of Infected Cardiac Implantable Electrical Devices with Subpectoral Plane Pocket Revision
Authors: Chatterjee Pallab , Sharma Anuj Kumar , Pratap Pranay , Dabas Ajay , Mishra Bharat , Mehare Samiksha 
Published: October 2021

Abstract
Introduction Infection of cardiac implantable electrical devices (CIEDs) may lead to serious complications. Complete CIED explantation is expensive, requires expertise, not free from complications, and may not be an option in patients with device dependence.
Aim To highlight that carefully selected infected CIEDs can be salvaged by placing the device in a subpectoral pocket below the pectoralis major muscle. We conducted a retrospective descriptive observational study.
Material and Methods Twelve patients (10 male and two female) with erosion, exposure or infection of infraclavicular, subcutaneously placed CIED were treated over a 30-month period between July 2018 and December 2020. The technique involved debridement and excision of a peridevice capsule, creating a subpectoral pocket beneath the pectoralis major muscle, and placing the CIED in a new pocket with total muscle coverage and closure of skin without tension.
Results Twelve patients (m = 10; f = 2) with a mean age of 65 years (range, 46–82 years) presented with infection of CIED within 9 months of implantation. None had sepsis or endocarditis. In nine patients, CIEDs were successfully salvaged with relocation to subpectoral pocket. Mean follow-up was 20 months (range, 8–30 months). Three out of 12 developed reinfection that ultimately required CIED explantation. There was no mortality.
Conclusion In the absence of sepsis or endocarditis, infected CIEDs may be attempted at salvage by subpectoral pocket placement. This obviates the need for potentially risky explantation or replacement of expensive CIEDs.
An Analysis of the Femoral Drilling Angle to Avoid Tunnel Collision during Double-Bundle Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction on the Knee
Authors: Kawanishi Yusuke , Kobayashi Makoto , Yasuma Sanshiro , Fukushima Hiroaki , Kato Jiro , Murase Atsunori , Takenaga Tetsuya , Yoshida Masahito , Kuroyanagi Gen , Kawaguchi Yohei , Nagaya Yuko , Murakami Hideki , Nozaki Masahiro 
Published: October 2021

AbstractConcomitant anterior cruciate ligament (ACL) and anterolateral ligament (ALL) reconstruction has been reported as an effective technique for providing rotational control of the knee. However, the intraoperative risk of collision with an ACL tunnel during the drilling for the femoral ALL tunnel has been described. The purpose of this study was to investigate the various femoral drilling procedures to avoid tunnel collisions during combined double-bundle ACL and ALL reconstruction. Nine cadaveric knees were used in this study. ACL drilling was performed through the anteromedial portal to footprints of the posterolateral bundle at 120° (PL120) and 135° (PL135) knee flexion and the anteromedial bundle at 120° (AM120) and 135° (AM135) knee flexion. ALL drilling was performed at 0° (Cor0-ALL) and 30° (Cor30-ALL) coronal angles using a Kirschner wire (K-wire). The distance between the ALL footprint and ACL K-wire outlets, axial angles of ALL K-wires colliding with ACL K-wires, and distances from the ALL footprint to the collision point were measured. From these values, the safe zone, defined as the range of axial angles in which no collisions or penetrations occurred, was identified by simulation of tunnels utilized for reconstruction grafts in each drilling procedure. The point-to-point distance from the ALL footprint to the K-wire outlet was significantly greater in the AM120 than the AM135 (13.5 ± 3.1, 10.8 ± 3.2 mm; p = 0.048) and in the PL135 than the PL120 (18.3 ± 5.5, 16.1 ± 6.5 mm; p = 0.005) conditions, respectively. During an ACL drilling combination of PL135/AM120, a safe zone of > 45° in Cor30-ALL was identified. With a narrow safe zone during the PL135/AM120 combination only, the risk of femoral tunnel collisions in combined double-bundle ACL and ALL reconstruction is high. AM drilling at 120° and PL drilling at > 135° knee flexion, combined with ALL drilling at 30° coronal angle and > 45° axial angle, may reduce this risk.
Investigation of Langdon effect on the stimulated backward Raman and Brillouin scattering
Authors: Qiu Jie , Hao Liang , Cao Lihua , Zou Shiyang 
Published: October 2021

Abstract
In a laser-irradiated plasma, the Langdon effect makes the electron energy distribution function tend to a super-Gaussian distribution, which has important influence on laser plasma instabilities. In this work, the influence of a super-Gaussian electron energy distribution function on the convective stimulated backward Raman scattering and stimulated backward Brillouin scattering is studied systematically for a wide range of typical plasma parameters in the inertial confinement fusion. Distinct behaviors are found for stimulated Raman scattering and stimulated Brillouin scattering in the variation trend of the peak spatial growth rate and the corresponding wavelength of the scattered light. Especially, the Langdon effect on the stimulated Brillouin scattering in plasmas with different ion species and isotopes is analyzed in detail, and the parameter boundary for judging the variation trend of the peak spatial growth rate of stimulated Brillouin scattering with the super-Gaussian exponent is presented for the first time. In certain plasma parameter region, it is found that the Langdon effect could enhance stimulated Brillouin scattering in mixed plasma, which may attenuate the improvement in suppressing stimulated Brillouin scattering by mixing low-Z ions into the high-Z plasma. The comprehension of Langdon effect on stimulated Raman scattering and stimulated Brillouin scattering would contribute to a better understanding of laser plasma instabilities in experiments.
Lugsail lag windows for estimating time-average covariance matrices
Authors: Vats D , Flegal J M 
Published: October 2021

Summary
Lag windows are commonly used in time series analysis, econometrics, steady-state simulation and Markov chain Monte Carlo to estimate time-average covariance matrices. In the presence of positive correlation in the underlying process, estimators of this matrix almost always exhibit significant negative bias, leading to undesirable finite-sample properties. We propose a new family of lag windows specifically designed to improve finite-sample performance by offsetting this negative bias. Any existing lag window can be adapted into a lugsail equivalent with no additional assumptions. We use these lag windows in spectral variance estimators and demonstrate their advantages in a linear regression model with autocorrelated and heteroskedastic residuals. We further employ the lugsail lag windows in weighted batch means estimators because of their computational efficiency on large simulation output. We obtain bias and variance results for these multivariate estimators and significantly weaken the mixing condition on the process. Superior finite-sample properties are demonstrated in a vector autoregressive process and a Bayesian logistic regression model.
Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study
Authors: Smyth Andrew , O’Donnell Martin , Hankey Graeme J , Rangarajan Sumathy , Lopez-Jaramillo Patricio , Xavier Denis , Zhang Hongye , Canavan Michelle , Damasceno Albertino , Langhorne Peter , Avezum Alvaro , Pogosova Nana , Oguz Aytekin , Yusuf Salim ,   INTERSTROKE investigators
Published: October 2021

Abstract

Aims
In INTERSTROKE, we explored the association of anger or emotional upset and heavy physical exertion with acute stroke, to determine the importance of triggers in a large, international population.

Methods and results
INTERSTROKE was a case–control study of first stroke in 32 countries. Using 13 462 cases of acute stroke we adopted a case-crossover approach to determine whether a trigger within 1 hour of symptom onset (case period), vs. the same time on the previous day (control period), was associated with acute stroke. A total of 9.2% (n = 1233) were angry or emotional upset and 5.3% (n = 708) engaged in heavy physical exertion during the case period. Anger or emotional upset in the case period was associated with increased odds of all stroke [odds ratio (OR) 1.37, 99% confidence interval (CI), 1.15–1.64], ischaemic stroke (OR 1.22, 99% CI, 1.00–1.49), and intracerebral haemorrhage (ICH) (OR 2.05, 99% CI 1.40–2.99). Heavy physical exertion in the case period was associated with increased odds of ICH (OR 1.62, 99% CI 1.03–2.55) but not with all stroke or ischaemic stroke. There was no modifying effect by region, prior cardiovascular disease, risk factors, cardiovascular medications, time, or day of symptom onset. Compared with exposure to neither trigger during the control period, the odds of stroke associated with exposure to both triggers were not additive.

Conclusion
Acute anger or emotional upset was associated with the onset of all stroke, ischaemic stroke, and ICH, while acute heavy physical exertion was associated with ICH only.
A Mediterranean Lifestyle and Frailty Incidence in Older Adults: The Seniors-ENRICA-1 Cohort
Authors: Maroto-Rodriguez Javier , Delgado-Velandia Mario , Ortolá Rosario , García-Esquinas Esther , Martinez-Gomez David , Struijk Ellen A , Lopez-Garcia Esther , Rodríguez-Artalejo Fernando , Sotos-Prieto Mercedes 
Published: October 2021

Abstract

Background
Frailty is a geriatric syndrome that entails high risk of hospitalization, disability, and death. While adherence to Mediterranean diet has been associated with lower risk of frailty, the joint effect of diet and lifestyle is uncertain. This study examined the association between a Mediterranean lifestyle (diet, customs, and traditions) and frailty incidence in older adults.

Methods
We analyzed data from 1 880 individuals aged ≥ 60 from the prospective Seniors-ENRICA-1 cohort. Adherence to the Mediterranean lifestyle was assessed at baseline with the 27-item MEDLIFE index (higher scores representing better adherence), divided into 3 blocks: (1) “Mediterranean food consumption,” (2) “Mediterranean dietary habits” (practices around meals),” and (3) “Physical activity, rest, social habits and conviviality.” Frailty was ascertained as the presence of ≥ 3 of the 5 Fried criteria: (a) Exhaustion; (b) Muscle weakness; (c) Low physical activity; (d) Slow walking speed; and (e) Unintentional weight loss. Main statistical analyses were performed using logistic regression models, adjusting for the main confounders.

Results
After a 3.3-year follow-up, 136 incident frailty cases were ascertained. Compared with participants in the lowest tertile of the MEDLIFE score, the OR (95% CI) for frailty was 0.88 (0.58–1.34) for the second tertile, and 0.38 (0.21–0.69) for the third tertile (p-trend = .003). Blocks 1 and 3 of the MEDLIFE score were independently associated with lower frailty risk. Most items within these blocks showed a tendency to reduced frailty.

Conclusions
Higher adherence to a Mediterranean lifestyle was associated with lower risk of frailty.
Low Serum Klotho Associated With All-cause Mortality Among a Nationally Representative Sample of American Adults
Authors: Kresovich Jacob K , Bulka Catherine M 
Published: October 2021

Abstract
α-Klotho (klotho) is a protein involved in suppressing oxidative stress and inflammation. In animal models, it is reported to underlie numerous aging phenotypes and longevity. Among a nationally representative sample of adults aged 40–79 years in the United States, we investigated whether circulating concentrations of klotho is a marker of mortality risk. Serum klotho was measured by ELISA on 10 069 individuals enrolled in the National Health and Nutrition Examination Survey between 2007 and 2014. Mortality follow-up data based on the National Death Index were available through December 31, 2015. After a mean follow-up of 58 months (range: 1–108), 616 incident deaths occurred. Using survey-weighted Cox regression models adjusted for age, sex, and survey cycle, low serum klotho concentration (&lt;666 pg/mL) was associated with a 31% higher risk of death (compared to klotho concentration &gt; 985 pg/mL, hazard ratio [HR]: 1.31, 95% confidence interval [CI]: 1.00, 1.71, p = .05). Associations were consistent for mortality caused by heart disease or cancer. Associations of klotho with all-cause mortality did not appear to differ by most participant characteristics. However, we observed effect modification by physical activity, such that low levels of serum klotho were more strongly associated with mortality among individuals who did not meet recommendation-based physical activity guidelines. Our findings suggest that, among the general population of American adults, circulating levels of klotho may serve as a marker of mortality risk.
Embodied Cognition and Media Engagement: When the Loneliness of the Protagonist Makes the Reader Sense Coldness (and Vice Versa)
Authors: Tal-Or Nurit , Razpurker-Apfeld Irene 
Published: October 2021

Abstract
Embodied cognition research documents the interplay between physical sensations and corresponding psychological experiences within the individual. Accordingly, physical warmth leads to a sense of social inclusion, and being socially rejected leads to physical coldness. In the current research, we demonstrate that these embodied cognition relationships also apply to a media consumer and a media character with whom the consumer identifies. In Study 1, participants (N  =  120) read one of four narratives in which we manipulated identification with the protagonist and her social exclusion/inclusion situation. In Study 2 (N  =  120), the narrative described the protagonist experiencing coldness/warmth in high/low identification conditions. The findings suggest that when the character experiences either the physical or the psychological state, the identifying consumer consequently experiences either psychological feelings or physical sensations, respectively. We discuss potential limitations of the study and also its contribution to media psychology and to embodied cognition research.
Why NATO survived Trump: the neglected role of Secretary-General Stoltenberg
Authors: Schuette Leonard August 
Published: October 2021

Abstract
The election of Donald Trump posed an existential challenge to NATO. At the end of his tenure, however, the US president had neither withdrawn membership nor substantially undermined the alliance from within. This article helps explain the puzzle of why NATO survived Trump's presidency. Extant explanations emphasize domestic factors such as the US foreign policy machinery and entrenched liberal ideology, structural reasons and Trump's idiosyncratic personality. While these accounts possess some explanatory value, they remain incomplete as they omit one central factor: NATO's leadership. Drawing on more than twenty original interviews with senior officials, the article demonstrates that particularly Secretary-General Stoltenberg's strategic responses were a necessary factor in changing Trump's stance on burden-sharing and helped maintain a robust deterrence policy toward Russia. These findings carry important implications both for theoretical debates on international organizations' agency in fending off contestation and policy debates on which actors shape NATO by emphasising the hitherto understated role of the secretary-general.
Probability of Stoma in Incident Patients With Crohn’s Disease in Sweden 2003-2019: A Population-based Study
Authors: Everhov Åsa H , Kalman Thordis Disa , Söderling Jonas , Nordenvall Caroline , Halfvarson Jonas , Ekbom Anders , Ludvigsson Jonas F , Olén Ola , Myrelid Pär 
Published: October 2021

Abstract

Background
Surgery rates in patients with Crohn’s disease have decreased during the last few decades, and use of antitumor necrosis agents (anti-TNF) has increased. Whether these changes correlate with a decreased probability of stoma is unknown. The objective of this study was to investigate the incidence of stoma in patients with Crohn’s disease over time.

Methods
Through linkage of national registers, we identified patients who were diagnosed with Crohn’s disease in 2003–2014 and were followed through 2019. We compared formation and closure of stomas over the calendar periods of diagnosis (2003–2006, 2007–2010, and 2011–2014).

Results
In a nationwide cohort of 18,815 incident patients with a minimum 5 years of follow-up, 652 (3.5%) underwent formation of a stoma. This was mostly performed in conjunction with ileocolic resection (39%). The 5-year cumulative incidence of stoma formation was 2.5%, with no differences between calendar periods (P = .61). Less than half of the patients (44%) had their stoma reversed. Stomas were more common in elderly-onset compared with pediatric-onset disease: 5-year cumulative incidence 3.6% vs 1.3%. Ileostomies were most common (64%), and 24.5% of the patients who underwent stoma surgery had perianal disease at end of follow-up. Within 5 years of diagnosis, 0.8% of the incident patients had a permanent stoma, and 0.05% had undergone proctectomy. The time from diagnosis to start of anti-TNF treatment decreased over calendar periods (P &lt; .001).

Conclusions
Despite increasing use of anti-TNF and a low rate of proctectomy, the cumulative incidence of stoma formation within 5 years of Crohn’s disease diagnosis has not decreased from 2003 to 2019.
Policy Signaling and Foreign Electoral Uncertainty: Implications for Currency Markets
Authors: Slaski Alexander 
Published: October 2021

AbstractThis paper examines the effects of foreign electoral shocks on currency markets. I develop a theory of signaling and uncertainty to explain why elections in countries with close economic ties should affect exchange rates. Methodologically, this paper focuses on several case studies, with the 2016 US election as a central case. I utilize an event analysis framework to measure the impact of the election on the Mexican peso by exploiting the plausible exogeneity of Donald Trump's tweets. I also measure changes in the peso using Trump's predicted chance of winning the election and show that the peso is weakest when Trump has the highest chance of winning the election. In addition, I include a series of robustness checks and analyses of other notable recent cases when electoral uncertainty affected currencies in other countries, including the 2018 Brazilian election. The results quantify the effect of foreign elections on exchange rates, building on the existing literature that focuses on how domestic elections shape currency markets. I conclude with a discussion of the external validity of the phenomenon demonstrated by the cases in the paper, charting future research on the topic and outlining ways to extend the findings.
Coup Agency and Prospects for Democracy
Authors: Albrecht Holger , Koehler Kevin , Schutz Austin 
Published: October 2021

AbstractThis research note introduces new global data on military coups. Conventional aggregate data so far have conflated two distinct types of coups. Military interventions by leading officers are coups “from above,” characterized by political power struggles within authoritarian elite coalitions where officers move against civilian elites, executive incumbents, and their loyal security personnel. By contrast, power grabs by officers from the lower and middle ranks are coups “from below,” where military personnel outside of the political elite challenge sitting incumbents, their loyalists, and the regime itself. Disaggregating coup types offers leverage to revise important questions about the causes and consequences of military intervention in politics. This research note illustrates that coup attempts from the top of the military hierarchy are much more likely to be successful than coups from the lower and middle ranks of the military hierarchy. Moreover, coups from the top recalibrate authoritarian elite coalitions and serve to sustain autocratic rule; they rarely produce an opening for a democratic transition. Successful coups from below, by contrast, can result in the breakdown of authoritarian regimes and generate an opening for democratic transitions.
First Report of Adult Aedes aegypti (Diptera: Culicidae) Resistance to Pyrethroids in Argentina
Authors: Harburguer Laura , Gonzalez Paula V , Zerba Eduardo 
Published: October 2021

Abstract
Severe human arboviral diseases can be transmitted by the mosquito Aedes aegypti (Linnaeus), including dengue, chikungunya, Zika, and yellow fever. Adult control using spatial sprays with adulticides is recommended only when dengue outbreaks occur. In Argentina, mainly pyrethroids, like cis-permethrin, have been used as an adulticide, especially since 2008. The evolution and spread of resistance to insecticides is a major concern for vector control. This study reports for the first time pyrethroid resistance in Ae. aegypti adults from Argentina, in the city of Salvador Mazza (Salta). WHO discriminating doses of 0.75% were used for permethrin, 0.05% for deltamethrin, and 5% for malathion. Also the discriminating dose for cis-permethrin (0.6%) was calculated and evaluated for the first time. We found a resistance ratio 50 (RR50) of 10.3 (9.7–10.4) for cis-permethrin, which is considered as high resistance. Our results also indicated resistance to deltamethrin (22.6% mortality) and permethrin (53.6% mortality), and a total susceptibility to malathion (100% mortality). Results from this study highlight the importance of the correct use of insecticides within an Integrated Vector Management (IVM) approach and of early detection of resistance to enable Ae. aegypti control in Argentina. More studies are needed to determine the spread of mosquito resistance to pyrethroids.