bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in University Teacher’s Pedagogical Activity in the Context of Digitalization of Education
Authors: Batrakova I. S. , Glubokova E. N. , Pisareva S. A. , Tryapitsyna A. P. 
Published: September 2021

The purpose of this article is to consider the changes in university teacher’s pedagogical activity in the conditions of a rapid transformation of higher education and propose a theoretical and empirical substantiation of the importance of teacher’s understanding of the value-semantic attitude to pedagogical activity, which is not limited only to mastering digital competencies, but consists in mastering pedagogical knowledge that allows you to critically analyze the productivity of modern educational strategies and methods.The conducted research was based on the methodology of post-non-classical science, which implies the widespread use of qualitative research methods that reflect the convergence of explanatory and interpretative research approaches, the use of representations, opinions, attitudes, and values of the research participants as full data.The article describes the results of studying the university teachers’ attitude to changes, the value orientations of the ongoing changes, as well as the main difficulties faced by university teachers in the context of digitalization of education – the design of educational and training programs, modern educational and methodological complex, the organization of productive self-directed work and communication with students in the educational process.The main directions of overcoming the identified difficulties are given – the construction of flexible curricula within the framework of the Federal State Educational Standard of Higher Education, the development of the digital educational environment of the university and updating the content of the professional development programs for teaching staff. The conclusion is made about the increasing importance of pedagogical knowledge in teacher’s professional activity in the conditions of a modern university.
Hubungan Fatigue Terhadap Kualitas Hidup Pasien Hemodialisa
Authors: Gina Nurdina  , Dian Anggraini  
Published: September 2021

Latar Belakang : Hemodialisa membantu meningkatkan harapan hidup pasien penyakit ginjal kronis, namun pasien juga sering melaporkan masalah dari pengobatan tersebut salah satunya fatigue yang merupakan gejala paling umum dari pasien hemodialisa dan sering dikaitkan dengan masalah kualitas hidup . Tujuan : Mengetahui hubungan fatigue terhadap kualitas hidup pasien hemodialisis. Metode : Desain penelitian yang digunakan adalah studi korelasional dengan pendekatan cross-sectional. Populasi penelitian ini adalah pasien yang menjalani hemodialisis di berbagai Klinik Hemodialisis di Kota Bandung dengan tehnik pengambilan sampel menggunakan consecutive sampling . Instrumen yang digunakan dalam penelitian ini yaitu the Fatigue Severity Scale (FSS) dan Kidney Disease Quality of Life Short Form 36 (KDQoL-SF36). Analisis univariat menggunakan distribusi frekuensi. Analisis bivariat dilakukan dengan menggunakan uji korelasi pearson. Hasil : Dari 34 responden sebagian besar pasien mengalami fatigue dengan rerata tingkat fatigue 41.18 (SD=17.11). Sekitar 41% responden memiliki skor fatigue tinggi (45<FAS<=63). Rerata skor KDQoL-SF36 pada aspek daftar gejala/masalah 66.02 (SD=9.06), aspek efek penyakit ginjal 43.70 (SD=10.68), aspek beban penyakit ginjal 12.13 (SD=5.94), aspek komponen kesehatan fisik 35.7 9 (SD=6.58) dan aspek komponen kesehatan mental 45.51 (SD=7.82). Terdapat hubungan antara fatigue dengan aspek beban penyakit ginjal dan komponen kesehatan fisik terlihat dari nilai p value <0.05 dengan nilai koefisien korelasi sebesar (-0.491) dan (-0.515). Kesimpulan: Semakin tinggi skor fatigue maka semakin rendah skor aspek kualitas hidupnya
Forage growth, biomass yield and nutrient content of two different hybrid Napier cultivars grown in Bangladesh
Authors: Ahamed S , Rakib MRH , Jalil MA 
Published: September 2021

A 2×3 factorial experiment was conducted to compare two cultivars; Bangladesh Livestock Research Institute developed Napier hybrid-3 (BN-3) (Pennisetum purpureum) and Pakchong-1 (Pennisetum purpureum× P. glaucum) in terms of forage growth, biomass yield, and nutritional quality. Cultivars were cultivated in 03 blocks with 03 replicates and were harvested at 03 cutting periods (40, 50, and 60 days). Plot sizes for each cultivar were 25 m2 (5m × 5m), and in every plot, twenty-five stem cuttings with two healthy nodes per cutting were planted with (1×1) m spacing. The effects of cultivar and cutting period were significant on plant height, leaves per tiller, leaf DM production, and leaf stem ratio (LSR). Highest plant height (P<0.01) and leaves per tiller (P<0.05) were consistently produced by BN-3, while Pakchong-1 produced the highest amount of CP (P<0.05), LSR (P<0.05), tiller diameter (P<0.01) and diameter of the lowest node (P<0.01). Based on the %DM, DM yield, and CP yield, BN-3 performed better cutting at 50 days after the first plantation, but Pakchong-1 performed better cutting at 60 days after the first plantation. From the forage standpoint, Pakchong-1 seems to have little advantages over BN-3 because of its higher DM, LSR, and CP production.
Bang. J. Anim. Sci. 2021. 50 (1):43-49
Strategi Pengembangan Bisnis Usaha Mikro Kecil Menengah Keripik Pisang Dengan Pendekatan Business Model Kanvas
Authors: Suwarni Emi , Handayani Maidiana Astuti 
Published: September 2021

The aim of this research is to describe the business model canvas and to create a business transformation design. The research was carried out at the MSMEs Arabar Shop Bandar Lampung, which is one of the MSMEs whose main activity is marketing Banana Chips. This research uses a descriptive method with a qualitative approach, namely explaining in depth about the situation or process being researched, namely the Arabar Shop MSMEs. The key informants in this research are the owners of MSMEs and staff. Data collection was carried out through in-depth interviews with key informants to obtain clear information about the application of the business model canvas at the Arabar Shop MSMEs. The general description of the company is explained by the position of company resources and their performance. The business transformation model is analyzed using a business model canvas approach and a customer empathy map. The result of the Arabar Shop MSMEs business transformation development strategy is to improve the preservation of customer segments and as their key resource. Increasing value propositions such as customer customization service, and social media in its value in customer channels and relationships generate a revenue stream from selling new products made of bananas and other ingredients. Increases are also needed in social activities in the main activities, increasing partners such as supplier and delivery services as the main partners, as well as additional costs for adjustments and social activities to the cost structure.

Abstrak
Tujuan penelitian ini adalah untuk mendeskripsikan Bisnis model kanvas dan menciptakan desain transformasi bisnis. Riset ini dilakukan pada UMKM Arabar Shop Bandar Lampung yang kegiatan utamanya adalah memasarkan keripik Pisang. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif, yakni menjelaskan dan menggambarkan secara mendalam tentang situasi atau proses objek yang diteliti yaitu UMKM Arabar Shop. Informan kunci dalam penelitian ini adalah pemilik UMKM dan staf bagian pemasaran. Pengumpulan data dilakukan melalui wawancara mendalam kepada informan penelitian sehingga diperoleh gambaran yang jelas mengenai penerapan business model canvas pada UMKM Arabar Shop. Deskripsi umum perusahaan dijelaskan melalui posisi sumber daya perusahaan dan kinerjanya. Model transformasi bisnisnya dianalisis dengan pendekatan bisnis model kanvas dan peta emphaty pelanggan. Hasil strategi pengembangan transformasi bisnis UMKM Arabar Shop adalah meningkatkan pelestarian segmen pelanggan sebagai kunci sumber daya mereka. Peningkatan proposisi nilai seperti layanan penyesuaian pelanggan, dan media sosial dalam nilainya di saluran dan hubungan pelanggan menghasilkan aliran pendapatan dari penjualan produk baru yang terbuat dari pisang dan bahan lainnya.
Kata kunci: Bisnis Model Canvas; Keripik Pisang; Strategi Pengembangan.
High Visceral Adipose Tissue Density Correlates With Unfavorable Outcomes in Patients With Intermediate-Stage Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Authors: Li Qiang , Zhang Lei , Hou Zhong-Heng , Zhao Dong-Xu , Li Jian-Bin , Zhang Shuai , Yin Yu , Ni Cai-Fang , Chen Tao 
Published: September 2021

Objectives:This study aimed to evaluate the association between different body composition features with prognostic outcomes of intermediate stage hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE).Methods:The areas and density of skeletal muscle area (SM) and adipose tissue [subcutaneous (SAT); visceral (VAT)] were calculated on the pre-TACE CT scans. Overall survival (OS) and progression-free survival (PFS) curves were calculated using the Kaplan–Meier method and compared with log-rank test. The discrimination and performance of body composition features were measured by area under time-dependent receiver operating characteristic (ROC) curve. Univariate and multivariate Cox proportional hazard analyses were applied to identify the association between body composition parameters and outcomes.Results:A significant prolonged OS and PFS was displayed by Kaplan–Meier curve analysis for HCC patients with VAT HU below −89.1 (25.1 months, 95% CI: 18.1–32.1 vs. 17.6 months, 95% CI: 16.3–18.8,p&lt; 0.0001, 15.4 months, 95% CI: 10.6–20.2 vs. 6.6 months, 95% CI: 4.9–8.3,p&lt; 0.0001, respectively). The 1-, 2-, 3-, and 5-year OS area under the curve (AUC) values of the VAT HU were higher than the other body composition parameters. Meanwhile, it is also found that 3-, 6-, 9-, and 12-month PFS AUC values of VAT HU were the highest among all the parameters. Univariate and multivariate Cox-regression analysis suggested a significant association between VAT density and outcomes (OS, HR: 1.015, 95% CI: 1.004–1.025,p= 0.005, PFS, HR: 1.026, 95% CI: 1.016–1.036,p&lt; 0.0001, respectively).Conclusion:The VAT density could provide prognostic prediction value and may be helpful to stratify the intermediate stage HCC patients.
The Construction and Analysis of ceRNA Network and Immune Infiltration in Kidney Renal Clear Cell Carcinoma
Authors: Deng Lugang , Wang Peixi , Qu Zhi , Liu Nan 
Published: September 2021

Background: Kidney renal clear cell carcinoma (KIRC) has the highest invasion, mortality and metastasis of the renal cell carcinomas and seriously affects patient’s quality of life. However, the composition of the immune microenvironment and regulatory mechanisms at transcriptomic level such as ceRNA of KIRC are still unclear.Methods: We constructed a ceRNA network associated with KIRC by analyzing the long non-coding RNA (lncRNA), miRNA and mRNA expression data of 506 tumor tissue samples and 71 normal adjacent tissue samples downloaded from The Cancer Genome Atlas (TCGA) database. In addition, we estimated the proportion of 22 immune cell types in these samples through “The Cell Type Identification by Estimating Relative Subsets of RNA Transcripts.” Based on the ceRNA network and immune cells screened by univariate Cox analysis and Lasso regression, two nomograms were constructed to predict the prognosis of patients with KIRC. Receiver operating characteristic curves (ROC) and calibration curves were employed to assess the discrimination and accuracy of the nomograms. Consequently, co-expression analysis was carried out to explore the relationship between each prognostic gene in a Cox proportional hazards regression model of ceRNA and each survival-related immune cell in a Cox proportional hazards regression model of immune cell types to reveal the potential regulatory mechanism.Results: We established a ceRNA network consisting of 12 lncRNAs, 25 miRNAs and 136 mRNAs. Two nomograms containing seven prognostic genes and two immune cells, respectively, were successfully constructed. Both ROC [area under curves (AUCs) of 1, 3, and 5-year survival in the nomogram based on ceRNA network: 0.779, 0.747, and 0.772; AUCs of 1, 3, and 5-year survivals in nomogram based on immune cells: 0.603, 0.642, and 0.607] and calibration curves indicated good accuracy and clinical application value of both models. Through co-correlation analysis between ceRNA and immune cells, we found both LINC00894 and KIAA1324 were positively correlated with follicular helper T (Tfh) cells and negatively correlated with resting mast cells.Conclusion: Based on the ceRNA network and tumor-infiltrating immune cells, we constructed two nomograms to predict the survival of KIRC patients and demonstrated their value in improving the personalized management of KIRC.
Expression Profiles of Circulating microRNAs in South African Type 2 Diabetic Individuals on Treatment
Authors: Weale Cecil J. , Matshazi Don M. , Davids Saarah F. G. , Raghubeer Shanel , Erasmus Rajiv T. , Kengne Andre P. , Davison Glenda M. , Matsha Tandi E. 
Published: September 2021

Aim: The influence of disease duration and anti-diabetic treatment on epigenetic processes has been described, with limited focus on interactions with microRNAs (miRNAs). miRNAs have been found to play key roles in the regulation of pathways associated with type 2 diabetes mellitus (T2DM), and expression patterns in response to treatment may further promote their use as therapeutic targets in T2DM and its associated complications. We therefore aimed to investigate the expressions of circulating miRNAs (miR-30a-5p, miR-1299, miR-182-5p, miR-30e-3p and miR-126-3p) in newly diagnosed and known diabetics on treatment, in South Africa.Methods: A total of 1254 participants with an average age of 53.8years were included in the study and classified according to glycaemic status (974 normotolerant, 92 screen-detected diabetes and 188 known diabetes). Whole blood levels of miR-30a-5p, miR-1299, miR-182-5p, miR-30e-3p and miR-126-3p were quantitated using RT-qPCR. Expression analysis was performed and compared across groups.Results: All miRNAs were significantly overexpressed in subjects with known diabetes when compared to normotolerant individuals, as well as known diabetics vs. screen-detected (p&lt;0.001). Upon performing regression analysis, of all miRNAs, only miR-182-5p remained associated with the duration of the disease after adjustment for type of treatment (OR: 0.127, CI: 0.018–0.236, p=0.023).Conclusion: Our findings revealed important associations and altered expression patterns of miR-30a-5p, miR-1299, miR-182-5p, miR-30e-3p and miR-126-3p in known diabetics on anti-diabetic treatment compared to newly diagnosed individuals. Additionally, miR-182-5p expression decreased with increasing duration of T2DM. Further studies are, however, recommended to shed light on the involvement of the miRNA in insulin signalling and glucose homeostasis, to endorse its use as a therapeutic target in DM and its associated complications.
Redefining COVID-19 Severity and Prognosis: The Role of Clinical and Immunobiotypes
Authors: Torres-Ruiz Jiram , Pérez-Fragoso Alfredo , Maravillas-Montero José Luis , Llorente Luis , Mejía-Domínguez Nancy R. , Páez-Franco José Carlos , Romero-Ramírez Sandra , Sosa-Hernández Victor Andrés , Cervantes-Díaz Rodrigo , Absalón-Aguilar Abdiel , Nuñez-Aguirre Miroslava , Juárez-Vega Guillermo , Meza-Sánchez David , Kleinberg-Bid Ari , Hernández-Gilsoul Thierry , Ponce-de-León Alfredo , Gómez-Martín Diana 
Published: September 2021

BackgroundMost of the explanatory and prognostic models of COVID-19 lack of a comprehensive assessment of the wide COVID-19 spectrum of abnormalities. The aim of this study was to unveil novel biological features to explain COVID-19 severity and prognosis (death and disease progression).MethodsA predictive model for COVID-19 severity in 121 patients was constructed by ordinal logistic regression calculating odds ratio (OR) with 95% confidence intervals (95% CI) for a set of clinical, immunological, metabolomic, and other biological traits. The accuracy and calibration of the model was tested with the area under the curve (AUC), Somer’s D, and calibration plot. Hazard ratios with 95% CI for adverse outcomes were calculated with a Cox proportional-hazards model.ResultsThe explanatory variables for COVID-19 severity were the body mass index (BMI), hemoglobin, albumin, 3-Hydroxyisovaleric acid, CD8+ effector memory T cells, Th1 cells, low-density granulocytes, monocyte chemoattractant protein-1, plasma TRIM63, and circulating neutrophil extracellular traps. The model showed an outstanding performance with an optimism-adjusted AUC of 0.999, and Somer’s D of 0.999. The predictive variables for adverse outcomes in COVID-19 were severe and critical disease diagnosis, BMI, lactate dehydrogenase, Troponin I, neutrophil/lymphocyte ratio, serum levels of IP-10, malic acid, 3, 4 di-hydroxybutanoic acid, citric acid, myoinositol, and cystine.ConclusionsHerein, we unveil novel immunological and metabolomic features associated with COVID-19 severity and prognosis. Our models encompass the interplay among innate and adaptive immunity, inflammation-induced muscle atrophy and hypoxia as the main drivers of COVID-19 severity.
To Investigate the Risk of Herpes Zoster in Women With Endometriosis: A Taiwan National Population-Based Cohort Study
Authors: Hsu Chao-Yu , Ke Der-Shin , Lin Cheng-Li , Kao Chia-Hung 
Published: September 2021

Background: The objective of this study is to investigate the occurrence of herpes zoster (HZ) in patients with endometriosis.Methods: This retrospective population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. Between 2000 and 2012, women aged ≥20 years with newly diagnosed endometriosis were enrolled into the endometriosis group. Each patient with endometriosis was randomly matched to 4 controls according to age and index year. All the patients were traced from the index date to HZ diagnosis, loss to follow-up, death, or the end of December 2013.Results: In total, 19,147 patients with newly diagnosed endometriosis and 76,588 participants without endometriosis were enrolled. The incidence of HZ was higher in endometriosis persons (5.36 per 1,000 person-years) than in matched controls (4.43 per 1,000 person-years) (p &lt; 0.001). After adjustment for age and comorbidities, patients with endometriosis age ≤ 49 years (adjusted hazard ratio [aHR] = 1.17) (p &lt; 0.001) and 50–64 years (aHR = 1.27) (p &lt; 0.05) showed significantly higher risk of HZ than the corresponding controls. Among women without any comorbidities, patients with endometriosis were 1.22 times (p &lt; 0.001) more likely to have HZ than those without endometriosis.Conclusion: Taiwanese women with endometriosis may have a higher rate of HZ occurrence. Endometriosis seems to be a high burden for affected women. Therefore, we suggest that clinicians should be aware of HZ among women with endometriosis, although there may be ethnic differences.
Comparison of Inflammatory and Angiogenic Factors in the Aqueous Humor of Vitrectomized and Non-Vitrectomized Eyes in Diabetic Macular Edema Patients
Authors: Liang Youling , Yan Bin , Meng Zhishang , Xie Manyun , Liang Zhou , Zhu Ziyi , Meng Yongan , Ma Jiayue , Ma Bosheng , Yao Xiaoxi , Luo Jing 
Published: September 2021

Objectives: To compare the aqueous concentrations of inflammatory and angiogenetic factors in vitrectomized vs. non-vitrectomized eyes with diabetic macular edema (DME).Methods: Aqueous samples were obtained from 107 eyes with DME before intravitreal injection of anti-VEGF, 36 eyes with previous pars plana vitrectomy (PPV) combined with pan-retinal endolaser photocoagulation (PRP), and 71 treatment-naïve. Interleukin (IL)-6, IL-8, interferon-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and vascular endothelial growth factor (VEGF) were measured by cytometric bead array (CBA). Optical coherence tomography (OCT) was used for measuring central retinal thickness (CRT).Results: IL-6, IL-8, IP-10, and MCP-1 in aqueous humor of DME vitrectomized eyes were significantly higher than in non-vitrectomized DME eyes, while VEGF was lower than in non-vitrectomized DME eyes. VEGF in aqueous humor significantly correlated with CRT for DME in non-vitrectomized DME eyes. IL-6, IL-8, IP-10, and MCP-1 in aqueous humor were not significantly associated with VEGF for DME in vitrectomized eyes.Conclusions: Inflammation might play an important role in the pathogenesis of DME in vitrectomized eyes. Moreover, inflammation might play a central role in the development of DME via the VEGF-independent pathway. Thus, anti-inflammatory therapy might be a strategy for DME in vitrectomized eyes.
Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
Authors: Shurbaji Samar , Manaph Nimshitha P. Abdul , Ltaief Samia M. , Al-Shammari Abeer R. , Elzatahry Ahmed , Yalcin Huseyin C. 
Published: September 2021

A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer photothermal therapy. To be most effective, photothermal agents need to be internalized by the cancer cells. In this study, MXene was fabricated using chemical reactions and tested as a photothermal agent on MDA-231 breast cancer cells under static and physiological conditions. Fluid shear stress (∼0.1 Dyn/cm2) was applied using a perfusion system to mimic the physiological tumor microenvironment. The uptake of MXene was analyzed under fluid flow compared to static culture using confocal microscopy, scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and transmission electron microscopy (TEM). Furthermore, a viability assay was used to assess cell’s survival after exposing the treated cells to photothermal laser at different power densities and durations. We showed that when incubated with cancer cells, 2D MXene nanoparticles were successfully internalized into the cells resulting in increased intracellular temperatures when exposed to NIR laser. Interestingly, dynamic culture alone did not result in a significant increase in uptake suggesting the need for surface modifications for enhanced cellular uptake under shear stress.