bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Identification of Clinically Approved Medicines Against the main Protease of Sars-Cov-2 – A Causative Agent of Covid-19
Authors: Estari Mamidala  , Rakesh Davella  , Swapna Gurrapu  , Pujala Shivakrishna  
Published: January 2021

The COVID-19 pandemic triggered by SARS-CoV-2 is a worldwide health disaster. Main protease is an attractive drug target among coronaviruses, due to its vital role in processing the polyproteins that are translated from the viral RNA. There is presently no exact drug or treatment for this disease caused by SARS-CoV-2.Speeding up drug innovation is immediately required. In the present study, we report the potential inhibitory activity of some FDA approved drugs against SARS-CoV-2 main protease by molecular docking study to investigate their binding affinity in protease active sites. Total 47 FDA approved drugs were selected for molecular docking with main COVID-19 protease. The docking of selected drugs to the active site of protein was performed using AutoDock software. Docking was achieved to attain a population of potential conformations and alignments for the ligand at the binding site. Docking study revealed that great inhibitory efficacy of the one anti-H1N1 drug (Oseltamivir), one anti-TB drug (Rifampin), four anti-HIV drugs (Maraviroc, Etravirine, Indinavir, Rilpivirine) and seven anti- malarial drugs (Atovaquone, Quinidine, Halofantrine, Amodiaquine, Tetracylcine, Azithromycin, hydroxycholoroquine) was found since they could launch H2 bonds with different amino acid residues that caused an inhibition of SARS-CoV-2 protease activity with higher binding affinity ranging from (-10.67 to -8.3 kcal/mol). However, the in-silico abilities of the drug molecules tested in this study, further needs to be validated by carrying out in vitro and in vivo studies. Moreover, this study spreads the potential use of current drugs to be considered and used to comprise the fast expanding SARS-CoV-2 infection.
Case Report on Worldwide Deaths Cases of Covid 19 from December to Mid- May 2020 and Its Impact
Authors: Sumayya Rehaman  
Published: January 2021

The epidemic spate time has made to freeze the entire world of pandemic outbreak (Covid -19) Coronavirus disease 2019 which needs a crisis alert. WHO declared the Covid–19 of novel coronavirus as a public emergency and a pandemic outbreak? WHO report says, that in the end of mid-May, 2020 about 4,526,850 cases, 303,405 deaths (15%), 1,704,268 recovered (85%) were reported and about 81,997 total cases and 2,649 deaths have been reported in India. Moreover, the result of the outbreak has locked down many countries including China, USA, Italy, Spain, France, Germany, Japan and Vietnam. Within 23 weeks of its spread, it has affected almost 215 countries across the world. India is in the 12th most affected economy due to Global and domestic recession. The positive impact of the lockdown is on the healing of the environment pollution proved by its Air Quality index (AQI). On analysis of total affected cases and the total deaths from January to mid-May, 2020 and on comparison about 1.4% death cases are increased. The Crude Death Rate in the month of January- mid May, 2020 was 21.6, 35.1, 51.06, 70.8 and 67.02 per 1000 individuals of given time period. WHO has recommended the drugs on physician advice such as the hydroxychloroquine with the antibiotic azithromycin and antiviral drugs were acyclovir, ribavirin, ganciclovir and methylprednisolone for the Covid -19 for clinical practice. This review has briefed about coronavirus structure with virulence infection and case report on crude death rate and its impact on world economy as well as the environment.
Diversity of Economically Useful Wild Plants of Jhalana Forest, Jaipur
Authors: Reenu Agarwal  , Shilpi Rijhwani  
Published: January 2021

The Biodiversity of an area influences every aspect of the lives of people who inhabit it. Their living space and their livelihood depend on the ecosystem. Even people living in urban areas are dependent on the ecological services provided by the wilderness in the protected areas. The indigenous communities have played a vital role in the development and management of the environment through their traditional knowledge and practice. They use abundant plant biodiversity as fodder, fuel, food, medicine etc. Jhalana forest, situated in the heart of the Jaipur city, spread across an area of 17 square kilometres. The Aravalli Mountain Range is located nearby and surrounds the area with thick forest, which is home to varied flora and fauna. The study is to document nearly 40 species of wild plants of economic uses. Analysis of taxonomic group of plants revealed that a total of 40 wild plants species belonging to 33 genera and 21 families were listed. Vegetation of the study area is mainly dominated by the Anogeissus latifolia, Anogeissus pendula and Boswellia serrata. Analysis of habits of plants documented show that trees share the largest proportion with 23species followed by shrub with 6 species, along with herb with 7species and Climber with 4 species Among the 40 species 26 are used as medicinal, 15 species are edible, 6 species used as fodder, 5 species used as fuel and 1 species is used as timber. Due to deforestation, colonization and industrialization there is an urgent need is felt to undertake ethnobotanical studies before extinction of the tribal life and Sustainable Utilization of wild plants.
The Effects of Multi-Level Group Identification on Intergroup Helping Behavior
Authors: Brown Jason L. , Sprinkle Geoffrey B. , Way Dan 
Published: January 2021

ABSTRACT
We conduct an experiment to examine the effects of multi-level group identification on intergroup helping behavior. We predict and find that stronger identification with a sub-group and a superordinate group—separately and interactively—increase helping behavior. We provide evidence that the relationships between stronger identification and helping behavior operate in part through increased salience of superordinate group boundaries, perceived potential benefits to one's own group of intergroup helping, and positive affect. Collectively, our findings illustrate the importance of understanding how individuals identify with the different groups naturally present in organizations and highlight how identification can be used as an informal control to motivate important organizational behaviors. Such an understanding can help firms determine the best organizational hierarchy, develop communication and control strategies to build identification at appropriate levels, and establish evaluation and compensation systems that measure and reward outcomes in a manner that accounts for these group effects.
ONLINE DIGITAL PLATFORMS DURING COVID-19 IN EFL CLASSES: VISUAL IMPAIRMENT STUDENT’ PERCEPTION
Authors: Hamid Sitti Maryam 
Published: January 2021

ABSTRACT. Due to the COVID-19 Pandemic, the government decided to implement work and learning from home. Teachers are expected to teach online. It also applied to teaching and learning English. Thus, Google Classroom, WhatsApp, and Zoom are commonly used as online learning platforms by EFL teachers and students during pandemic. The online digital platforms are also used as the main tool to provide teaching materials not only for the sighted student but also for Visual Impairment student (VIs). The present study is aimed at investigating how Visual Impairment student (VIs) perceive utilizing Digital Platforms in online learning, the barriers VIs faced in utilizing Digital Platforms, and the kinds of Digital Platforms that appropriate for Visual Impairment student (VIs). The study involved one Visual Impairment student (low vision) in one of the private universities of Makassar, South Sulawesi. Questionnaires and interviews were used to collect data. It analyzed using descriptive qualitative research. The results of the study showed that Visual impairment has a positive response towards Google Classroom, WhatsApp, and Zoom in understanding the content, improving the ability to use various digital platforms in learning, presenting more interesting teaching materials, selecting of Digital Platforms by English Language skill, and hindering of utilizing Digital Platform. Even though slow-speed internet connectivity, take longer, and vague learning instruction was considered to be barriers in using Digital Platforms. Besides, Zoom is a digital platform that appropriates for VIs; Zoom is a video conferencing learning platform that offers VIs an opportunity to respond in real-time and there is a recording system that records the learning process from start to finish.
INVESTIGATING THE STUDENT-TEACHER TECHNOLOGY COMPETENCY FOR ENGLISH LANGUAGE TEACHING: DOES IT MATTER?
Authors: Anas Ismail , Akhmad Akhmad 
Published: January 2021

The availability of technological tools, the Student and Teacher Technology Competency (STTC) are the essential considerations for the effective use of technology integration in ELT. However, these three aspects are closely interrelated as the key indicators of successful teaching English with technology. This paper reports on the result of an investigation on STTC involving 6 English lecturers and 80 students across the multidisciplinary courses at a vocational higher education setting. The survey is concerned with four domains of technology competencies, they are 1) basic technology operation, 2) personal/ professional use of technology tools, 3) social, ethical, and human issues, and 4) application of technology in instruction (classroom and web-based technology in instruction). This study’s implications call for an inclusion of technological literacy skills in pre-service and in-service EFL teacher professional development programs and education.
PENERAPAN METODE CREATIVE LEARNING CYCLE PADA PEMBELAJARAN PEMROGRMAN BAGI SISWA SMP
Authors: ANGGRAINI DIAN , SEPTIANA ASYIFA IMANDA , SYAWANODYA INDIRA 
Published: January 2021

Pelajaran pemrograman semestinya sudah diajarkan sejak dini. Untuk dapat mengajarkan pemrograman kepada siswa dibutuhkan usaha yang besar agar dapat diterima dan membuat siswa tertarik untuk mempelajari pemrograman. Pada penelitian ini, kami menyajikan model pembelajaran creative learning cycle untuk mendukung siswa dalam pembelajaran pemrograman. Model Creative Learning Cycle memiliki lima tahapan yang meliputi imagine, create, play, share, dan reflect, masing masing tahapan dapat membantu siswa dalam mengembangkan ide pemikiran yang kreatif dalam pemecahan masalah dan mampu memberikan solusi dari permasalahan tersebut sehingga dapat meningkatkan minat siswa dalam pembelajaran pemrograman. Berdasarkan hasil analisis diperoleh bahwa 76% siswa menyukai pembelajaran pemrograman, 71% siswa berpikir pemrograman mudah dimengerti dan 74% siswa bahkan ingin belajar pemrograman lebih lanjut. Kata Kunci: Creative Learning Cycle, Metode Pembelajaran, Pemrograman
PENGENALAN SISTEM ISYARAT BAHASA INDONESIA (SIBI) MENGGUNAKAN GRADIENT-CONVOLUTIONAL NEURAL NETWORK
Authors: DARMATASIA DARMATASIA 
Published: January 2021

Penelitian ini bertujuan untuk melakukan pengenalan alfabet pada Sistem Isyarat Bahasa Indonesia (SIBI). Penelitian ini memiliki dua kontribusi utama, Pertama dilakukan pengumpulan dataset alfabet SIBI. Kedua, pengenalan alfabet SIBI menggunakan algoritma Convolutional Neural Network (CNN). Pada penelitian ini, citra masukan berupa alfabet bahasa isyarat pada lapisan input diberikan filter gradient agar bentuk objek menjadi lebih jelas. Hasil penelitian menunjukkan bahwa pemberian filter pada lapisan input dapat meningkatkan akurasi pengenalan yaitu sekitar 85%. Citra masukan yang tidak difilter hanya memperoleh akurasi sebesar 25%. Akurasi terbaik yang diperoleh yaitu 98% dengan meningkatkan jumlah iterasi. Metode yang diusulkan juga diuji menggunakan tiga benchmark dataset. Hasil pengujian menunjukkan bahwa metode yang diusulkan dapat meningkatkan akurasi pengenalan pada benchmark dataset yang memiliki background yang kompleks.Kata Kunci: Convolutional Neural Network; Gradient; Sistem Isyarat Bahasa Indonesia
IMPLEMENTASI METODE AHP DAN MOORA UNTUK PEMERINGKATAN EMARKETPLACE INDONESIA TAHUN 2020 KUARTAL KEDUA
Authors: YUNIANTO ERA , WIBOWO ARI PUTRA 
Published: January 2021

Banyak pelaku usaha telah memanfaatkan emarketplace. Pemilihan emarketplace yang tepat sangat berpengaruh terhadap profitabilitas bisnis. Dalam penelitian ini akan melakukan pemeringkatan emarketplace di Indonesia tahun 2020 kuartal kedua menggunakan metode AHP dan MOORA. Metode AHP digunakan untuk pembobotan kriteria, sedangkan metode MOORA digunakan untuk pemeringkatan alternatif. Dari hasil analisis data diperoleh bobot kriteria kualitas pelayanan (38,6%), bobot kualitas sistem (21%), bobot kualitas informasi (31,4%) dan bobot kualitas vendor (9,1%). Dari hasil pemeringkatan diperoleh nilai kinerja Shopee adalah 0,618, nilai kinerja Tokopedia adalah 0,568, dan nilai kinerja bukalapak adalah 0,542. dari nilai kinerja dapat disimpulkan bahwa Shopee merupakan alternatif terbaik dalam pemeringkatan emarketplace di Indonesia tahun 2020 kuartal kedua menggunakan metode AHP dan MOORA. Diharapkan hasil penelitian ini dapat dijadikan rekomendasi bagi para pelaku usaha dalam memilih emarketplace sehingga berdampak terhadap profitabilitas bisnis. Kata Kunci: AHP, emarketplace, MOORA.
The Success of The Teaching Methods of Prophet Muhammad (PBUH) in Engineering Education
Authors: Dadach Zin Eddine 
Published: January 2021

Literature has shown that effective teachers have succeeded in making students feel good about school and learning, thus increasing student achievement. Moreover, students in an actively taught class do a better job of learning (memorizing) the material they are exposed to, compared to those in a passively taught section. The main goal of this paper is to show that the teaching methods of Prophet Muhammad (PBUH) are successful tools for engineering education. First, to fully deliver his message, Prophet Muhammad (PBUH) addressed the hearts of followers to become the beloved one in order to inspire them to listen to his message. Secondly, in order to maximize the effects of his message, he used a type of speech that made his followers think during his educational methods. He utilized analogies and active learning strategies to enhance the imagination and curiosity of the listeners. As utilized by The Prophet (PBUH), the literature review highlights the use of analogies and active learning have a positive impact on both performance and the motivation of students to learn. Moreover, these teaching strategies engage students in higher thinking to be deeply involved in learning. From this perspective, the success of the utilization of the teaching methodology of our Beloved Teacher (PBUH) is demonstrated by the fact that the performance of thirty-eight (69%) students was higher in a process control course than the average performance in the department. Additionally, the results also show that the combined methodology, including analogies and active learning, increased the intrinsic motivation of twenty-two (40%) students.
DEFINING THE CONCEPTS & APPROACHES IN VERNACULAR ARCHITECTURE STUDIES
Authors: Asadpour Ali 
Published: January 2021

Abstrak_ Makalah ini membahas arsitektur vernakular dalam hal konsep dan pendekatan dalam studi. Keragaman definisi, sikap, dan preferensi telah menghasilkan berbagai pendekatan dalam beberapa dekade terakhir. Mengenali perbedaan ini dapat membantu untuk mendapatkan pemahaman yang lebih dalam tentang kondisi saat ini dan cakrawala masa depan dalam penelitian. Tujuan dari penelitian ini termasuk mengidentifikasi dan mengkategorikan pendekatan dominan terhadap arsitektur vernakular. Metode penelitian yang digunakan adalah kualitatif dan deskriptif. Hasil penelitian mengidentifikasi lima kecenderungan yang dianggap arsitektur vernakular sebagai objek estetika, fenomena biologis (jenis dan evolusi), substansi material-fisik (penjelasan fisik), realitas budaya-sosiologis, dan akhirnya sebagai fenomena antropologis. Pendekatan-pendekatan ini merepresentasikan perpindahan dari dokumentasi ke interpretasi, objektivitas ke subjektivitas, dan primitif ke biasa dalam studi. Fenomenologi, hermeneutika, semiotik, studi gender, dan feminisme menetapkan cakrawala baru bagi penelitian arsitektur vernakular. Evolusi sikap dapat dijelaskan di bawah perubahan paradigma penelitian dari positivisme ke post-positivisme dan fenomenologi.Kata kunci: Arsitektur Vernakular; Desain Iklim; Budaya; Sosiologi; Tipologi. Abstract_ This paper addresses vernacular architecture in terms of concepts and approaches in studies. The diversity of definitions, attitudes, and preferences has led to a variety of approaches in recent decades. Recognizing these differences can help to obtain a deeper understanding of today's conditions and future horizons in research. The objectives of this study included identifying and categorizing the dominant approaches toward vernacular architecture. The research used a qualitative and descriptive method. The results identified five tendencies considered vernacular architecture as an object of aesthetics, a biological phenomenon (types and evolution), a material-physical substance (physical explanations), a cultural-sociological reality, and finally as an anthropological phenomenon. These approaches represented the movement from documentation to interpretation, objectivity to subjectivity, and primitive to ordinary in the studies. Phenomenology, hermeneutics, semiotics, gender studies, and feminism set new horizons for vernacular architectural research. The evolution of attitudes can be explained under the change in research paradigms from positivism to post-positivism and phenomenology.Keywords: Vernacular Architecture; Climatic Design; Culture Sociology; Typology.
Educação permanente em saúde: o cuidado seguro à criança hospitalizada
Authors: Barbosa da Silva Valentina , Conceição Stipp Marluci Andrade , Alves Mendes Vanessa , Cabral Siqueira Tatiane , Rodrigues Tadeus Vivian , Souza de Oliveira Andrade Josimeire 
Published: January 2021

Relatar a experiência da educação permanente em saúde na prática da higienização das mãos. Trata-se de um relato de experiência sobre a educação permanente em saúde na temática de higienização das mãos com profissionais de saúde de um hospital infantil. As atividades foram desenvolvidas em conjunto com a Comissão de Controle de Infecção Hospitalar, divididas em quatro momentos. A experiência possibilitou a aquisição de novos conhecimentos e percepção das dificuldades que os profissionais possuem para a adesão da técnica correta de higienização das mãos, além de evidenciar a importância da educação permanente com os profissionais para a mudança no processo de trabalho. A realização das atividades permitiu a vivência de experiências significativas para o grupo, envolvendo aspectos pessoais, acadêmicos e profissionais contribuindo para o conhecimento da situação e incentivo a continuação de novos projetos que estimulem a educação permanente no âmbito hospitalar.
Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct
Authors: Wattanapitayakul Suvara K. , Chularojmontri Linda , Schäfer-Korting Monika 
Published: January 2021

Abstract
Ultraviolet B (UVB) induces morphological and functional changes of the skin. This study investigated the effect of UVB on keratinocyte senescence and the development of reconstructed human epidermis (RHE). Primary normal human keratinocytes (NHK) from juvenile foreskin were irradiated with UVB (30 mJ cm−2) and these effects were compared to NHK that underwent senescence in the late passage. UVB enhanced the accumulation of reactive oxygen species (ROS) and halted cell replication as detected by BrdU cell proliferation assay. The senescence phenotype was evaluated by beta-galactosidase (β-gal) staining and qPCR of genes related to senescent regulation, i.e. p16INK4a, cyclin D2, and IFI27. Senescence induced by high dose UVB resulted in morphological changes, enhanced β-gal activity, elevated cellular ROS levels and reduced DNA synthesis. qPCR revealed differential expression of the genes regulated senescence. p16INK4a expression was significantly increased in NHK exposed to UVB whereas enhanced IFI27 expression was observed only in cultural senescence. The levels of cyclin D2 expression were not significantly altered either by UVB or long culturing conditions. UVB significantly induced the aging phenotype in keratinocytes and impaired epidermal development. RHE generated from UVB-irradiated keratinocytes showed a thinner cross-sectional structure and the majority of keratinocytes in the lower epidermis were degenerated. The 3D epidermis model is useful in studying the skin aging process.
Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells
Authors: Huang Shuaishuai , Tuergong Gulimire , Zhu Hangjie , Wang Xue , Weng Guobin , Ren Yu 
Published: January 2021

Abstract
Renal cell carcinoma (RCC) is generally acknowledged as the most resistant primary malignancy unresponsive to conventional radiotherapy and chemotherapy treatments. Norcantharidin (NCTD), a therapeutic compound derived from medicinal plants, has been shown to trigger apoptosis, as well as antimetastatic and antioxidant activities in several tumor cells. However, NCTD’s mechanism of antitumor activity in the RCC cell line remains unclear. In this study, we report that NCTD led to a time- and dose-dependent inhibition of cell proliferation. It had also markedly induced apoptosis and G2/M phase cell cycle arrest in a dose-dependent manner by decreasing the expressions of pro-caspase-3, pro-caspase-9, cyclin B1, and pCDC25C while increasing active caspase-3, cleaved-PARP, P21, and pCDC2 levels. Interestingly, NCTD treatment provoked the phosphorylation of extracellular-regulated protein kinase (ERK) and c-Jun-N-terminal kinase (JNK), but not of p38 MAPK. Moreover, SCH772984 and SP600125, ERK and JNK inhibitors, respectively, could partially abolish NCTD-induced apoptosis and G2/M phase cell cycle arrest. Collectively, these findings suggest that NCTD might activate JNK and ERK signaling pathways, consequently inducing apoptosis and G2/M arrest through the modulation of related proteins. This study provided evidence that NCTD is a promising therapeutic drug for the treatment of RCC.
Sitagliptin: a potential drug for the treatment of COVID-19?
Authors: Bardaweel Sanaa K. , Hajjo Rima , Sabbah Dima A. 
Published: January 2021

Abstract
Recently, an outbreak of a fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. Possible interaction of SARS-CoV-2 with DPP4 peptidase may partly contribute to the viral pathogenesis. An integrative bioinformatics approach starting with mining the biomedical literature for high confidence DPP4-protein/gene associations followed by functional analysis using network analysis and pathway enrichment was adopted. The results indicate that the identified DPP4 networks are highly enriched in viral processes required for viral entry and infection, and as a result, we propose DPP4 as an important putative target for the treatment of COVID-19. Additionally, our protein-chemical interaction networks identified important interactions between DPP4 and sitagliptin. We conclude that sitagliptin may be beneficial for the treatment of COVID-19 disease, either as monotherapy or in combination with other therapies, especially for diabetic patients and patients with pre-existing cardiovascular conditions who are already at higher risk of COVID-19 mortality.