bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liquisolid Orodispersible Tablets of Valeriana officinalis L. Root Extraction: Formulation, Development and Evaluation
Authors: Asgarirad Hossein , Farmoudeh Ali , AmirKhanloo Shervin , Babaei Amirhossein , Hosseini Seyyedeh Saba , Kishani Yashar 
Published: June 2021

Background:
Valerian root extract is used in traditional medicine to treat sleep disorders.
According to previous studies, sedative effects are related to the presence of valerenic acid. Formulating
orodispersible tablets (ODTs) is an effective and cost-benefit technique for accelerating drugs'
therapeutic effects. This study aimed to formulate ODTs of valerian root extract and evaluate their
properties.

Materials and Methods:
Valerian root was extracted by percolation in 70% ethanol. The solubility of
valerenic acid was investigated in various liquid carriers. The extract was uniformly dispersed in the
selected carrier (Tween 80), then mixed with other excipients, and compressed into tablets. Fourteen
formulations with different amounts of sodium starch glycolate (SSG, as a super disintegrant) and
camphor (as a sublimating agent) were prepared. The physicochemical properties of the ODTs, drug
release rates, and microbial limit tests (MLTs) were studied.

Results:
Both SSG and camphor accelerated tablet disintegration rates and their composition showed a
synergistic effect (P<0.05). The infrared spectroscopy revealed no chemical interaction between formulation
components. The MLTs confirmed that a limited number of microbial colonies were grown
in the liquid medium, and no pathogen growth occurred in the specific culture media.

Conclusion:
The results revealed that Valerian ODT's physicochemical properties were significantly
improved compared to conventional tablets. The technique can be utilized for other poorly watersoluble
pharmaceuticals.
A Path-based Method for Identification of Protein Phenotypic Annotations
Authors: Gao Jian , Hu Bin , Chen Lei 
Published: June 2021

Background:
Identification of protein phenotypic annotations is an essential and challenging
problem in modern genetics. Such problem is related to some serious diseases, including
cancers, HIV and so on. The factors of genotype and environment increase the difficulties in determining
the phenotype of proteins. The experiment methods to achieve such a goal are always timeconsuming
and expensive.

Objective:
The aim of this study was to design a quick and cheap method for determining the phenotypes
of proteins.

Methods:
In this study, we proposed a network computational method to identify novel phenotypic
annotations of proteins. To execute such method, a heterogeneous network was constructed, which
contained three sub-networks: protein network, phenotypic type network, and protein-phenotypic
type network. The method tried to find out all paths with limited length, which connected one protein
and one phenotypic type. A scoring scheme was adopted to count obtained paths and induced a
score to indicate the associations between them.

Results and Conclusion:
The ROC and PR curve analyses were done to evaluate the performance
of the method, indicating the utility of the method. Our method was superior to other network
methods, which incorporated popular network algorithms.
Identification of Risk Molecular Subtype of Colon Cancer with Lymphovascular Invasion
Authors: Jin Qing , Liang Binhua , Chen Xiujie , Liu Huiwen 
Published: June 2021

Background:
Although surgical resection generally yields excellent outcomes, a number
of patients with colon cancer still have relapse or metastasis after surgery. Adjuvant chemotherapy
in tumor stage III has been demonstrated to eradicate micrometastasis and improve survival, whereas
the benefits of adjuvant chemotherapy in tumor stage II remain controversial. The leading cause
is the lack of understanding of the molecular basis of underlying metastatic mechanisms.

Objective:
This study aimed to identify molecular subtype(s) of colon cancer with a high risk of
metastasis and provide potential biomarkers for prognostic prediction in tumor stage II.

Method:
Based on the assumption that colon cancer evolves because of the stepwise accumulation
of a series of genetic mutations, we performed a systematic investigation on the molecular basis of
colon cancer through applying restart random walk on the PPI network. To compare functional similarity
of patients, we extracted mutation-propagating modules of each patient and calculated their
enrichment score in 50 hallmark gene sets. According to functional similarity matrix, we classified
colon cancers with positive lymphovascular invasion and the prognosis of molecular subtypes. We
determined the molecular characteristics of subtypes by enrichment analysis of subtype-specific
genetic mutations. Additionally, we identified potential biomarkers for predicting patients with a
high risk of metastasis in stage II through differential analysis of miRNA expression profiles of
subtypes. Then we used two independent data sets to construct a random forest classifier and performed
10-fold cross-validation of miRNA biomarkers.

Results:
Firstly, we identified two molecular subtypes of colon cancer with positive lymphovascular
invasion as well as their associated biological characteristics: LVI1=Canonical subtype (110,
85%); LVI2=Metastatic subtype (20, 15%). Secondly, we identified 11 miRNA biomarkers for predicting
patients with a high risk of metastasis in tumor stage II.

Conclusion:
Our findings put forward a detailed classification for colon cancer and provided risk
biomarkers for stage II patients to determine whether to take adjuvant chemotherapy after surgery.
System Identification of Dampers Using Chaotic Accelerated Particle
Swarm Optimization
Authors: Talatahari S. , Talatahari B. , Tolouei M. 
Published: June 2021

Aims:
Different chaotic APSO-based algorithms are developed to deal with high non-linear
optimization problems. Then, considering the difficulty of the problem, an adaptation of these algorithms
is presented to enhance the algorithm.

Background: :
Particle swarm optimization (PSO) is a population-based stochastic optimization technique
suitable for global optimization with no need for direct evaluation of gradients. The method
mimics the social behavior of flocks of birds and swarms of insects and satisfies the five axioms of
swarm intelligence, namely proximity, quality, diverse response, stability, and adaptability. There are
some advantages to using the PSO consisting of easy implementation and a smaller number of parameters
to be adjusted; however, it is known that the original PSO had difficulties in controlling the balance
between exploration and exploitation. In order to improve this character of the PSO, recently, an
improved PSO algorithm, called the accelerated PSO (APSO), was proposed, and preliminary studies
show that the APSO can perform superiorly.

Objective:
This paper presents several chaos-enhanced accelerated particle swarm optimization methods
for high non-linear optimization problems.

Method:
Some modifications to the APSO-based algorithms are performed to enhance their performance.
Then, the algorithms are employed to find the optimal parameters of the various types of hysteretic
Bouc-Wen models. The problems are solved by the standard PSO, APSO, different CAPSO,
and adaptive CAPSO, and the results provide the most useful method. The sub-optimization mechanism
is added to these methods to enhance the performance of the algorithm.

Result:
Seven different chaotic maps have been investigated to tune the main parameter of the APSO.
The main advantage of the CAPSO is that there is a fewer number of parameters compared with other
PSO variants. In CAPSO, there is only one parameter to be tuned using chaos theory.

Conclusion:
To adapt the new algorithm for susceptible parameter identification algorithm, two series
of Bouc-Wen model parameters containing standard and modified Bouc-Wen models are used. Performances
are assessed on the basis of the best fitness values and the statistical results of the new approaches
from 20 runs with different seeds. Simulation results show that the CAPSO method with
Gauss/mouse, Liebovitch, Tent, and Sinusoidal maps performs satisfactorily.
Ogilvie Syndrome Following Caesarean Section: A Case Report
Authors: Sninate Sanae , Bellamlih Habib , Allioui Soukaina , Jroundi Leila , Laamrani Fatima Zahrae 
Published: June 2021

Background. Ogilvie syndrome is a rare postpartum complication. It is characterized by an acute colonic pseudo-obstruction which occurs in the absence of a mechanical cause. Early detection of the diagnosis is essential to avoid cecal perforation.
Case report. We report a case of Ogilvie syndrome following caesarean section in a 39-year-old woman (gravida 2, para 2) with a history of secondary infertility 10 years ago due to tubal stenosis and subserous fibroma, which led to the indication for cesarean section in second pregnancy at 39 weeks of gestation. Three days after cesarean section, the patient presented with significant abdominal distension and tenderness, vomiting, weakness, and nausea; an abdominal X-ray showed cecal distension. Abdominal computed tomography scan with intravenous contrast revealed distension of the ascending and transverse colon with air-fluid levels but without transitional mechanical obstruction. The patient was successfully treated.
Conclusions. Ogilvie syndrome is a rare but serious complication that should be considered in fit young patients who present with pain, severe abdominal distension and failure to pass flatus after caesarean section.
The Relationship Between Perceived Parental Attitude and Life Satisfaction Among University Students
Authors: Işik Nurten Arslan 
Published: June 2021

Introduction. The effect of parental attitudes and behaviors in raising their children on the individual’s life has been the subject of numerous studies for many years. There is a strong correlation between parental attitudes and the child’s ability to be satisfied with life.
The objective of the research was to determine the relationships between perceived parental attitudes (overprotection, rejection, emotional warmth) and life satisfaction among university students. We investigated whether parental attitudes play a role in predicting life satisfaction among university students, and what role they play.
Materials and Methods. The study was conducted from June 2020 to September 2020. Data were collected using Google Forms. Each person consented to anonymously participate in the study and was informed about the objectives of the study being a descriptive one. The population of the study consisted of nursing students enrolled in the Faculty of Health Sciences. For this purpose, 220 students at the age of 20 to 30 years participated in the study. The assessment battery consisted of Student Demographic Form, the Short-Egna Minnen Beträffande Uppfostran (Own Memories of Upbringing), and the Life Satisfaction Scale.
Results. There was a significant negative correlation between maternal rejection and life satisfaction among the students. Male students were more likely to perceive their fathers as being disapproving than female students did. These findings were discussed in line with the studies in the related literature.
Conclusions. High life satisfaction is a variable that protects young people from risk factors. Therefore, a focus should be placed on increasing life satisfaction among students. Parental attitude is an effective factor for life satisfaction among students. For this reason, it can be said that it would be beneficial to inform families about appropriate parental attitudes to increase their children’s life satisfaction.
Peer-to-Peer Social Media Communication About Dietary Supplements Used for Weight Loss and Sports Performance Among Military Personnel: Pilot Content Analysis of 11 Years of Posts on Reddit
Authors: Sharp Kendall J , Vitagliano Julia A , Weitzman Elissa R , Fitzgerald Susan , Dahlberg Suzanne E , Austin S Bryn 
Published: June 2021

BackgroundOver 60% of military personnel in the United States currently use dietary supplements. Two types of dietary supplements, weight loss and sports performance (WLSP) supplements, are commonly used by military personnel despite the associated serious adverse effects such as dehydration and stroke.ObjectiveTo understand peer-to-peer communication about WLSP supplements among military personnel, we conducted a pilot study using the social media website, Reddit.MethodsA total of 64 relevant posts and 243 comments from 2009 to 2019 were collected from 6 military subreddits. The posts were coded for year of posting, subreddit, and content consistent with the following themes: resources about supplement safety and regulation, discernability of supplement use through drug testing, serious adverse effects, brand names or identifiers, and reasons for supplement use.ResultsA primary concern posted by personnel who used supplements was uncertainty about the supplements that were not detectable on a drug test. Supplements to improve workout performance were the most frequently used.ConclusionsOur pilot study suggests that military personnel may seek out peer advice about WLSP supplements on Reddit and spread misinformation about the safety and effectiveness of these products through this platform. Future directions for the monitoring of WLSP supplement use in military personnel are discussed.
Using Living Labs to Explore Needs and Solutions for Older Adults With Dementia: Scoping Review
Authors: Verloo Henk , Lorette Adrien , Rosselet Amoussou Joëlle , Gillès de Pélichy Estelle , Matos Queirós Alcina , von Gunten Armin , Perruchoud Elodie 
Published: June 2021

Background
Numerous living labs have established a new approach for studying the health, independent living, and well-being of older adults with dementia. Living labs interact with a broad set of stakeholders, including students, academic institutions, private companies, health care organizations, and patient representative bodies and even with other living labs. Hence, it is crucial to identify the types of cocreations that should be attempted and how they can be facilitated through living labs.

Objective
This study aims to scope publications that examine all types of living lab activities, exploring the needs and expectations of older adults with dementia and seeking solutions, whether they live in the community or long-term health care facilities (LTHFs).

Methods
This scoping review was reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations for the extension of scoping reviews. We searched six bibliographic databases for publications up to March 2020, and a forward-backward citation chasing was performed. Additional searches were conducted using Google Scholar. The quality of the selected papers was assessed.

Results
Of the 5609 articles identified, we read 58 (1.03%) articles and retained 12 (0.21%) articles for inclusion and final analysis. All 12 articles presented an innovative product, developed in 4 main living labs, to assist older adults with cognitive disorders or dementia living in the community or LTHFs. The objectives of these studies were to optimize health, quality of life, independent living, home care, and safety of older adults with cognitive disorders or dementia, as well as to support professional and family caregivers or reduce their burdens. The overall methodological quality of the studies ranged from poor to moderate.

Conclusions
This scoping review identified several living labs playing a pivotal role in research aimed at older adults with dementia living in the community or LTHFs. However, it also revealed that living labs should conduct more better-quality interventional research to prove the effectiveness of their technological products or service solutions.

International Registered Report Identifier (IRRID)
RR2-10.2147/SHTT.S233130
A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study
Authors: O'Loughlin Patricia , Pavithra Pavithra , Regan John , Bennett Marc , Knight Rachel , Lenaert Bert , Marquez Melissa , Taddeo Michelle , Griffith James , Shapiro Rita , Farina Francesca 
Published: June 2021

Background
Dementia is the most feared disease associated with aging. Prolonged fears about memory loss and dementia can have harmful consequences even in the absence of cognitive decline. Fear of dementia is associated with poorer health outcomes and psychological well-being and increased memory failures in older adults.

Objective
We will conduct a randomized controlled trial to determine the feasibility of a tailored, web-based mindfulness program to reduce fear of memory loss and increase quality of life in older adults experiencing heightened fear.

Methods
Eighty participants will be recruited and divided into 2 groups (40 in each group). One group will receive psychoeducation plus mindfulness training. A second group will receive psychoeducation, mindfulness training, and additional modules targeting maladaptive behavioral avoidance (ie, social and cognitive withdrawal).

Results
Our recent etiological model posits that maladaptive behavioral avoidance strategies critically underlie psychosocial dysfunction associated with fear of memory loss. Thus, we predict better outcomes in the second group, including reduced fear of memory loss (primary outcome), Alzheimer disease, anxiety, and subjective memory failures, and increased quality of life (secondary outcomes). Outcome measures will be applied at 5 time points (before, baseline, interim, and after the intervention, and at 3-month follow-up). Data will be analyzed using mixed models and correlations.

Conclusions
Results from this study will contribute to the current literature on dementia-related fear and improve our understanding of how to effectively address and reduce these fears.

Trial Registration
ClinicalTrials.gov NCT04821960; https://clinicaltrials.gov/ct2/show/NCT04821960.

International Registered Report Identifier (IRRID)
PRR1-10.2196/30514
Prediction of Surface Roughness after Turning of Duplex Stainless Steel (DSS)
Authors: Abdulateef Osamah F. 
Published: June 2021

Feed Forward Back Propagation artificial neural network (ANN) model utilizing the MATLAB Neural Network Toolbox is designed for the prediction of surface roughness of Duplex Stainless Steel during orthogonal turning with uncoated carbide insert tool. Turning experiments were performed at various process conditions (feed rate, cutting speed, and cutting depth). Utilizing the Taguchi experimental design method, an optimum ANN architecture with the Levenberg-Marquardt training algorithm was obtained. Parametric research was performed with the optimized ANN architecture to report the impact of every turning parameter on the roughness of the surface. The results suggested that machining at a cutting speed of 355 rpm with a feed rate of 0.07 mm/rev and a depth of cut 0.4 mm was found to achieve lower surface roughness with, an increase in the cutting speed and feed rate with the increases of the surface roughness. In addition, an increase in the depth of cut was found to reduces the surface roughness. The outcome of this study showed that ANN is a versatile tool for prediction of surface roughness and may be easily extended with greater confidence to various metal cutting processes.
The Application of Virtual Reality to (Mechatronics Engineering) by Creating an Articulated Robotic Work Cell Using EON Reality V9.22.24.24477
Authors: Allaq Aiman Al- , Jaksic Nebojsa , Al-Amili Hussein Ali , Mahmood Dhuha Mohammed 
Published: June 2021

Virtual reality, VR, offers many benefits to technical education, including the delivery of information through multiple active channels, the addressing of different learning styles, and experiential-based learning. This paper presents work performed by the authors to apply VR to engineering education, in three broad project areas: virtual robotic learning, virtual mechatronics laboratory, and a virtual manufacturing platform. The first area provides guided exploration of domains otherwise inaccessible, such as the robotic cell components, robotic kinematics and work envelope. The second promotes mechatronics learning and guidance for new mechatronics engineers when dealing with robots in a safe and interactive manner. And the third provides valuable guidance for industry and robotic based manufacturing, allowing a better view and simulating conditions otherwise inaccessible.
INTERLOCUÇÕES ENTRE LA MULTIPLICACIÓN DRAMÁTICA - EDUARDO PAVLOVSKY - E O ARCO-ÍRIS DO DESEJO - AUGUSTO BOAL
Authors: De Oliveira Douglas Henrique , Bortolini Neide Das Graças de Souza 
Published: June 2021

Este artigo faz aproximações entre práxis teatrais desenvolvidas no contexto latino-americano de resistência aos regimes ditatoriais no século XX, nos âmbitos artístico, educacional, social e terapêutico, constituídas de poéticas políticas criadas por Eduardo Pavlovsky, na Argentina, e Augusto Boal, no Brasil. Essas epistemologias marcaram o pensamento estético e projetaram-se internacionalmente, uma vez que os autores foram exilados por suas expressões críticas e libertárias na área teatral. São trajetórias distintas que se aproximam especialmente pelo caráter de transformações sociais, políticas e interpessoais realizadas por estéticas de resistência na conjuntura das ditaduras latino-americanas. O argentino Pavlovsky desenvolve, entre outras importantes realizações, a abordagem La multiplicación dramática (1989), enquanto o brasileiro, partindo de seu Teatro do Oprimido, desenvolve O arco-íris do desejo: método Boal de teatro e terapia (1992), trabalhos que se assemelham por serem abordagens grupais terapêuticas que implicam mudanças psicossociais. Palavras-chaveTeatro. Terapia Grupal. Resistência.
JOGO, CURIOSIDADE E AD-MIRAÇÃO: INDÍCIOS DE APROXIMAÇÃO ENTRE A PEDAGOGIA DA AUTONOMIA FREIREANA E A PEGADOGIA DO TEATRO
Authors: Bezerra de Souza Henrique 
Published: June 2021

O presente artigo investiga a aproximação entre a noção de autonomia – tal como cunhada por Paulo Freire – e a prática do jogo em processos de ensino-aprendizagem em teatro. Para tanto, tece uma breve apresentação das ideias do educador pernambucano a respeito do processo de construção de conhecimento para, em seguida, relacionar tais reflexões a elementos presentes na prática do jogo. Na tentativa de encontrar os primeiros indícios dessa aproximação, toma como ponto de partida as características que Johan Huizinga atrela ao ato de jogar e, em seguida, analisa os jogos teatrais de Viola Spolin, buscando neles similaridades ao pensamento freireano. Nesse trajeto, se depara com desdobramentos que trespassam a metodologia realizada em sala de aula, revelando a importância da postura do sujeito docente no processo pedagógico. Palavras-chaveAutonomia. Jogo. Ensino-aprendizagem. Paulo Freire. Pedagogia do Teatro.