bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID 19 in Geriatric Patients in Vidharbha Region
Authors: Chamat Ayush , Nagrale Ninad , Bankar Nandkishor 
Published: July 2021

Introduction: Although all age groups are at risk of getting COVID-19, older people are at greater risk of developing serious illnesses as a result of the physical changes that come with aging and the onset of health symptoms Symptoms: Fever Cough Throat Throat Tiredness According to the current epidemiological evidence, patients with SARS-coV2 virus over the age of 80 are at greater risk of dying than younger patients, according to a study of Coronavirus 2019 (COVID-19) is a highly contagious disease caused by a novel coronavirus from Wuhan, China, was also recognized by the International Committee on Taxonomy of Viruses as acute acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ICTV).
Aim: Covid-19 in geriatric patients in vidharbha region
Materials and Methods: Covid 19 positive Patients went directly to the Observed Treatment in the Dept. of Medicine and Dept. of Respiratory, DMMC and SMHRC, Nagpur.
Results: Recovery is usually slower and more difficult. Most of us are concerned about our elderly relatives who live far away from us. They can experience anxiety as a result of living alone, being on a fixed income or pension, no longer driving and unable to use public transportation, and having their regular health checkups postponed. They may also be suffering from undiagnosed or poorly treated depression. COVID-19 has exacerbated the concerns of millions of elderly people.
Conclusion: We may also assist them by following the steps below. Ensure their medical supplies are stocked up.
Clinical Feature, Cause and Outcome in Female Paediatric Child with Osseomuscular Type of Wilson’s Disease
Authors: Yelekar Mayuri , Pahune Lina , Alwadkar Indu , Kawale Aparna 
Published: July 2021

Introduction: Genetically inherited diseases have grown in the last few decades. Wilson’s disease is one of those, named after the U.S.-born British neurologist Dr. Samuel Alexander Kinnier Wilson.
Case Presentation: A 12 years old female child was admitted in A.V.B.R. hospital with the chief complaints of altered behaviour, speech disturbances, no physical coordination, uncontrolled movement since 2 to 3 months and fever since 2-3 days. Golden brown eye discoloration was present. After physical examination and investigation doctor diagnosed it as a case of Wilson’s disease.
The Main Diagnosis, Therapeutic Intervention and Outcomes: After physical examination and investigation doctor diagnosed this as a case of Wilson’s disease. Zinc and vitamin supplements were given for 7 days to enhance immunity. Beta-blocker was given For 7days twice a day, Tab. Trietinine 250 mg was given once a day for 7 days to remove the heavy metal i.e. copper. She took all treatment and outcome was good. Her signs and symptoms got reduced and she was able to do her routine activities.
Conclusion: The diagnosis of Wilson's disease relies largely on clinical examination and laboratory confirmation of abnormal metabolism of copper. This case responded well to all treatment and her recovery was good.
The root cause analysis on failed patient‐specific measurements of pencil beam scanning protons using a 2D detection array with finite size ionization chambers
Authors: Ricci Jacob C. , Hsi Wen C. , Su Zhong , Mund Karl , Dawson Robert , Indelicato Daniel J. 
Published: July 2021

AbstractThe aim of this report is to present the root cause analysis on failed patient‐specific quality assurance (QA) measurements of pencil beam scanning (PBS) protons; referred to as PBS‐QA measurement. A criterion to fail a PBS‐QA measurement is having a <95% passing rate in a 3.0%‐3.0 mm gamma index analysis. Clinically, we use a two‐dimensional (2D) gamma index analysis to obtain the passing rate. The IBA MatriXX PT 2D detection array with finite size ionization chamber was utilized. A total of 2488 measurements performed in our PBS beamline were cataloged. The percentage of measurements for the sites of head/neck, breast, prostate, and other are 53.3%, 22.7%, 10.5%, and 13.5%, respectively. The measurements with a passing rate of 100 to >94%, 94 to >88%, and <88% were 93.6%, 5.6%, and 0.8%, respectively. The percentage of failed measurements with a <95% passing rate was 10.9%. After removed the user errors of either re‐measurement or re‐analysis, 8.1% became acceptable. We observed a feature of >3% per mm dose gradient with respect to depth on the failed measurements. We utilized a 2D/three‐dimensional (3D) gamma index analysis toolkit to investigate the effect of depth dose gradient. By utilizing this 3D toolkit, 43.1% of the failed measurements were improved. A feature among measurements that remained sub‐optimal after re‐analysis was a sharp >3% per mm lateral dose gradient that may not be well handled using the detector size of 5.0 mm in‐diameter. An analysis of the sampling of finite size detectors using one‐dimensional (1D) error function showed a large dose deviation at locations of low‐dose areas between two high‐dose plateaus. User error, large depth dose gradient, and the effect of detector size are identified as root causes. With the mitigation of the root causes, the goals of patient‐specific QA, specifically detecting actual deviation of beam delivery or identifying limitations of the dose calculation algorithm of the treatment planning system, can be directly related to failure of the PBS‐QA measurements.
Youth Mentoring Relationships and College Social and Academic Functioning: The Role of Mentoring Relationship Quality, Duration, and Type
Authors: McClain Cara M. , Kelner William C. , Elledge L. Christian 
Published: July 2021

AbstractThe aim of the present study was to examine how college students’ retrospective reports of youth‐mentoring experiences were associated with current sense of belonging and community, academic motivation, and college self‐efficacy, and to determine hows these outcomes vary as a function of mentoring relationship quality, duration, and type (e.g., natural versus program‐sponsored). Analyses were conducted in Mplus 8.0 on a sample of 400 college students. Our findings suggest that most college students endorse a mentoring relationship. We found that having a mentor was associated with increased college self‐efficacy. Among those with a youth mentor, relationship quality was positively associated with sense of belonging and college self‐efficacy while duration of the mentoring relationship and relationship type were not associated with college‐related outcomes. Further analyses were conducted to assess how the associations between relationship quality and the college‐related outcomes varied as a function of mentoring duration and type. Relationship quality was uniquely associated with these college‐related outcomes over and above student gender, race, and first‐generation status. Our findings suggest it may be important to prioritize the enhancement of mentor relationship quality as a mechanism to affect change in academic‐related outcomes.
Radical Trifluoroacetylation of Alkenes Triggered by a Visible‐Light‐Promoted C–O Bond Fragmentation of Trifluoroacetic Anhydride
Authors: Zhang Kun , Rombach David , Nötel Nicolas Yannick , Jeschke Gunnar , Katayev Dmitry 
Published: July 2021

AbstractWe report a mild and operationally simple trifluoroacylation strategy of olefines, that utilizes trifluoroacetic anhydride as a low‐cost and readily available reagent. This light‐mediated process is fundamentally different from conventional methodologies and occurs through a trifluoroacyl radical mechanism promoted by a photocatalyst, which triggers a C−O bond fragmentation. Mechanistic studies (kinetic isotope effects, spectroelectrochemistry, optical spectroscopy, theoretical investigations) highlight the evidence of a fleeting CF3CO radical under photoredox conditions. The trifluoroacyl radical can be stabilized under CO atmosphere, delivering the trifluoroacetylation product with higher chemical efficiency. Furthermore, the method can be turned into a trifluoromethylation protocol by simply changing the reaction parameters. Beyond simple alkenes, this method allows for chemo‐ and regioselective functionalization of small‐molecule drugs and common pharmacophores.
Instrument Set Decontamination Workflows Designed for Success in Sterile Processing
Authors: Mace Davis Courtney , Spear Joan M. 
Published: July 2021

ABSTRACTIn sterile processing, several factors can result in confusion and unpredictable quality outcomes in surgical instrument sets, including the large number of instruments to manage, the complexity of certain instruments, and the multiple instructions for cleaning solutions and cleaning equipment for use. At a multihospital health system, the director of sterile processing had a vision that involved designing standard decontamination workflows and standardized cleaning pathways based on quality concepts to support patient safety. When there was a pause in elective surgeries in the spring of 2020 as a result of the spread of coronavirus disease 2019, sterile processing personnel became available to participate in a project to create and test these new standardized cleaning pathways and decontamination workflows. This article provides an overview of the inception and execution of this project and how instrument cleaning and decontamination was streamlined to promote a more efficient workflow for sterile processing.
A Systematic Review of Interventions Used to Enhance Implementation of and Compliance With the World Health Organization Surgical Safety Checklist in Adult Surgery
Authors: Liu Liang Qin , Mehigan Sinead 
Published: July 2021

ABSTRACTThe focus of this systematic review is to identify and synthesize the evidence for effectiveness of interventions to increase compliance with the World Health Organization Surgical Safety Checklist (SSC) for adult surgery. We searched a variety of databases and identified 24 peer‐reviewed articles of either a quantitative (n = 17), qualitative (n = 4), or mixed‐methods design (n = 3) published in English from January 1, 2008, to July 8, 2020. Interventions included modifying the ways of delivering the SSC, integrating or tailoring the SSC to local context or existing practice, promoting clinician awareness and engagement, and managing policies. Despite a lack of common outcome measures, all quantitative and mixed‐methods study results showed a significant positive effect on SSC compliance. A few researchers reported nonsignificant or negative changes in certain aspects with the interventions. Additional research is needed to address SSC compliance measures globally and outcomes in developing countries.
Synthesis of new 7‐amino‐3,4‐dihydroquinolin‐2(1H)‐one‐peptide derivatives and their carbonic anhydrase enzyme inhibition, antioxidant, and cytotoxic activities
Authors: Küçükbay Hasan , Gönül Zeynep , Küçükbay Fatümetüzzehra Zehra , Tekin Zehra , Angeli Andrea , Bartolucci Gianluca , Supuran Claudiu T. , Tatlıcı Eray , Apohan Elif , Yeşilada Özfer 
Published: July 2021

AbstractSix new monopeptides, seven new dipeptides, and two deprotected monopeptide dihydroquinolinone conjugates were prepared by the benzothiazole‐mediated method and their structures were confirmed by nuclear magnetic resonance, mass, infrared spectroscopy, and elemental analysis methods. The human carbonic anhydrase (hCA) I and hCA II enzyme inhibition activities of the compounds were determined using the stopped‐flow instrument. The synthesized peptide–dihydroquinolinone conjugates 2, 3, 6, 10, 13, and 15 showed inhibition against the hCA II enzyme in the range of 15.7–65.7 µM. However, none of the compounds showed inhibition of hCA I at a concentration of 100 µM. The antioxidant activities of the compounds were also examined using the DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) radical scavenging method at concentrations of 12.5–125 µg/ml, but when compared with the standard antioxidant compounds α‐tocopherol and butylated hydroxyanisole (BHA), weak antioxidant activities were detected. The cytotoxic effects of four compounds against the A549 and BEAS‐2B cell lines were also investigated. Among the compounds studied, compound 7 was found to be most effective, with the IC50 values on the A549 cells for 48 and 72 h being 26.87 and 9.979 µg/ml, respectively, and the IC50 values on the BEAS‐2B cells being >100 µg/ml. None of the tested compounds showed antimicrobial activity in the concentration range (800–1.56 µg/ml) studied.
An engineered microfluidic blood‐brain barrier model to evaluate the anti‐metastatic activity of β‐boswellic acid
Authors: Vakilian Saeid , Alam Khurshid , Al‐Kindi Juhaina , Jamshidi‐Adegani Fatemeh , Rehman Najeeb Ur , Tavakoli Rezvan , Al‐Riyami Khamis , Hasan Anwarul , Zadjali Fahad , Csuk Rene , Al‐Harrasi Ahmed , Al‐Hashmi Sulaiman 
Published: July 2021

AbstractBackgroundThe development of anti‐cancer drugs with the ability to inhibit brain metastasis through the blood‐brain barrier (BBB) is substantially limited due to the lack of reliable in vitro models.Main MethodsIn this study, the Geltrex‐based Transwell and microfluidic BBB models were applied to screen the effect of β‐boswellic acid (β‐BA) on the metastasis of MDA‐MB‐231 cells through the BBB in static and dynamic conditions, respectively.Major ResultsThe toxicity assay revealed that β‐BA deteriorates MDA‐MB‐231 cells, while β‐BA had no detectable toxic effects on human umbilical vein endothelial cells (HUVECs) and astrocytes. Trans‐endothelial electrical resistance evaluation showed sustainable barrier integrity upon treatment with β‐BA. Vimentin expression in HUVECs, evaluated using western blot, confirmed superior barrier integrity in the presence of β‐BA. The obtained results were confirmed using an invasion study with a cell tracker and a scanning electron microscope. β‐BA significantly inhibited metastasis by 85%, while cisplatin (Cis), a positive control, inhibited cancer cell migration by 12% under static conditions. Upon applying a dynamic BBB model, it was revealed that β‐BA‐mediated metastasis inhibition was significantly higher than that mediated by Cis.Conclusions and Implications In summary, the current study proved the anti‐metastatic potential of β‐BA in both static and dynamic BBB models.
Differential expression of microRNAs associated with neurodegenerative diseases and diabetic nephropathy in proteinl‐isoaspartyl methyltransferase‐deficient mice
Authors: Su Zhonghao , Ren Na , Ling Zicheng , Sheng Lanyue , Zhou Sirui , Guo Chunxia , Ke Zunji , Xu Tiefeng , Qin Zhenxia 
Published: July 2021

AbstractProteinl‐isoaspartyl methyltransferase (PIMT/PCMT1), an enzyme repairing isoaspartate residues in peptides and proteins that result from the spontaneous decomposition of normall‐aspartyl andl‐asparaginyl residues during aging, has been revealed to be involved in neurodegenerative diseases (NDDs) and diabetes. However, the molecular mechanisms for a putative association of PIMT dysfunction with these diseases have not been clarified. Our study aimed to identify differentially expressed microRNAs (miRNAs) in the brain and kidneys of PIMT‐deficient mice and uncover the epigenetic mechanism of PIMT‐involved NDDs and diabetic nephropathy (DN). Differentially expressed miRNAs by sequencing underwent target prediction and enrichment analysis in the brain and kidney of PIMT knockout (KO) mice and age‐matched wild‐type (WT) littermates. Sequence analysis revealed 40 differentially expressed miRNAs in the PIMT KO mouse brain including 25 upregulated miRNAs and 15 downregulated miRNAs. In the PIMT KO mouse kidney, there were 80 differentially expressed miRNAs including 40 upregulated miRNAs and 40 downregulated miRNAs. Enrichment analysis and a systematic literature review of differentially expressed miRNAs indicated the involvement of PIMT deficiency in the pathogenesis in NDDs and DN. Some overlapped differentially expressed miRNAs between the brain and kidney were quantitatively assessed in the brain, kidney, and serum‐derived exosomes, respectively. Despite being preliminary, these results may aid in investigating the pathological hallmarks and identify the potential therapeutic targets and biomarkers for PIMT dysfunction‐related NDDs and DN.
Immobilisation of Iron Porphyrin from an Equilibrium Solution with Diazonium‐Functionalised Axial Ligand: Dependence of Film Composition on Grafting Potential
Authors: Wu Ting , Brooksby Paula A. , Fitchett Christopher M. , Downard Alison J. 
Published: July 2021

AbstractIn dichloromethane solution, tetraphenylporphyrin iron (III) chloride (FeTPPCl) and 4‐(1H‐Imidazol‐1‐yl)aniline (Im‐Ph‐NH2) exist in equilibrium with axially‐coordinated [FeTPP(Im‐Ph‐NH2)n]+ (n=1 and 2). After in situ diazotisation of Im‐Ph‐NH2, electroreduction of the diazonium ion leads to deposition of a film incorporating [FeTPP(Im‐Ph)2]+ and uncoordinated Im‐Ph. In the 1 : 1 FeTPPCl:Im‐Ph‐NH2 grafting solution used in this work, Im‐Ph‐NH2 is mostly uncoordinated. However, the formation constant for axially coordinated Fe(II)TPP is significantly greater than for Fe(III)TPP+. Consequently, the relative amounts of coordinated and uncoordinated Im‐Ph in the films depends on whether the grafting scans traverse the potential for reduction of FeTPPCl. In addition, redox grafting can occur based on the Fe(III)/(II) couple of solution‐ and film‐based porphyrin. Electrochemistry, atomic force microscopy and X‐ray photoelectron spectroscopy reveal that the relative amount of free and coordinated Im‐Ph, and concentration of [FeTPP(Im‐Ph)2]+ in the films depend on the negative potential limit during grafting.
The Impact of C2 Insertion into a Carbazole Donor on the Physicochemical Properties of Dibenzo[a,j]phenazine‐Cored Donor–Acceptor–Donor Triads
Authors: Zimmermann Crocomo Paola , Kaihara Takahito , Kawaguchi. Soki , Stachelek Patrycja , Minakata Satoshi , de Silva Piotr , Data Przemyslaw , Takeda Youhei 
Published: July 2021

AbstractNovel electron donor–acceptor–donor (D‐A‐D) compounds comprising dibenzo[a,j]phenazine as the central acceptor core and two 7‐membered diarylamines (iminodibenzyl and iminostilbene) as the donors have been designed and synthesized. Investigation of their physicochemical properties revealed the impact of C2 insertion into well‐known carbazole electron donors on the properties of previously reported twisted dibenzo[a,j]phenazine‐core D‐A‐D triads. Slight structural modification caused a drastic change in conformational preference, allowing unique photophysical behavior of dual emission derived from room‐temperature phosphorescence and triplet–triplet annihilation. Furthermore, electrochemical analysis suggested sigma‐dimer formation and electrochemical polymerization on the electrode. Quantum chemical calculations also rationalized the experimental results.
Modeling of Single Droplet Mass Transfer of Acetic Acid with Triisooctylamine‐Based Solvent
Authors: Rudelstorfer Georg , Siebenhofer Matthäus , Grafschafter Annika 
Published: July 2021

AbstractThe design of mass transfer equipment based on single droplet mass transfer data is still a great challenge, although having been subject of intensive discussion for decades already. Extraction with chemical reaction may rather contribute to additional problems when modeling single droplet mass transfer. Single droplet mass transfer of acetic acid from aqueous carrier into triisooctylamine based solvents modified with the Lewis acid modifier isodecanol and the diluent Shellsol T has been investigated. Mass transfer of acetic acid into triisooctylamine‐based solvent droplets is strictly controlled (actually limited) by diffusion of the laden solvent from the interface into the droplet bulk phase.
Longer term outcomes with single‐agent belantamab mafodotin in patients with relapsed or refractory multiple myeloma: 13‐month follow‐up from the pivotal DREAMM‐2 study
Authors: Lonial Sagar , Lee Hans C. , Badros Ashraf , Trudel Suzanne , Nooka Ajay K. , Chari Ajai , Abdallah Al‐Ola , Callander Natalie , Sborov Douglas , Suvannasankha Attaya , Weisel Katja , Voorhees Peter M. , Womersley Lynsey , Baron January , Piontek Trisha , Lewis Eric , Opalinska Joanna , Gupta Ira , Cohen Adam D. 
Published: July 2021

BackgroundOn the basis of the DREAMM‐2 study (ClinicalTrials.gov identifier NCT03525678), single‐agent belantamab mafodotin (belamaf) was approved for patients with relapsed or refractory multiple myeloma (RRMM) who received ≥4 prior therapies, including anti‐CD38 therapy. The authors investigated longer term efficacy and safety outcomes in DREAMM‐2 after 13 months of follow‐up among patients who received belamaf 2.5 mg/kg.MethodsDREAMM‐2 is an ongoing, phase 2, open‐label, 2‐arm study investigating belamaf (2.5 or 3.4 mg/kg) in patients with RRMM who had disease progression after ≥3 lines of therapy and were refractory to immunomodulatory drugs and proteasome inhibitors and refractory and/or intolerant to an anti‐CD38 therapy. The primary outcome was the proportion of patients that achieved an overall response, assessed by an independent review committee.ResultsAs of January 31, 2020, 10% of patients still received belamaf 2.5 mg/kg. Thirty‐one of 97 patients (32%; 97.5% confidence interval [CI], 21.7%‐43.6%) achieved an overall response, and 18 responders achieved a very good partial response or better. Median estimated duration of response, overall survival, and progression‐free survival were 11.0 months (95% CI, 4.2 months to not reached), 13.7 months (95% CI, 9.9 months to not reached), and 2.8 months (95% CI, 1.6‐3.6 months), respectively. Response and survival outcomes in patients who had high‐risk cytogenetics or renal impairment were consistent with outcomes in the overall population. Outcomes were poorer in patients with extramedullary disease. In patients who had a clinical response and prolonged dose delays (>63 days; mainly because of corneal events), 88% maintained or deepened responses during their first prolonged dose delay. Overall, there were no new safety signals during this follow‐up.ConclusionsExtended follow‐up confirms sustained clinical activity without new safety signals with belamaf in this heavily pretreated patient population with RRMM.
Web service selection and composition based on uncertain quality of service
Authors: Zeyneb Yasmina Remaci , Fethallah Hadjila , Fadoua Lahfa 
Published: July 2021

AbstractWeb services are becoming a major utility for accomplishing complex tasks over the Internet. In practice, the end‐users usually search for Web service compositions that best meet the quality of service (QoS) requirements (i.e., QoS global constraints). Since the number of services is constantly increasing and their respective QoS is inherently uncertain (due to environmental conditions), the task of selecting optimal compositions becomes more challenging. To tackle this problem, we propose a heuristic based on majority judgment that allows for reducing the search space. In addition, we perform a constraint programming search to select the Top K compositions that fulfill the QoS global constraints. The experimental results demonstrate the high performance of our approach.