bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term clinical outcomes of external beam radiation therapy for oligometastatic prostate cancer: A combination of prostate‐targeted treatment and metastasis‐directed therapy
Authors: Aizawa Rihito , Takayama Kenji , Nakamura Kiyonao , Ogata Takashi , Inoue Takahiro , Yamasaki Toshinari , Kobayashi Takashi , Akamatsu Shusuke , Tashiro Yu , Ota Hideto , Ogawa Osamu , Mizowaki Takashi 
Published: April 2021

ObjectiveTo assess the efficacy of combination of prostate‐targeted treatment and metastasis‐directed therapy for oligometastatic prostate cancer.MethodsWe retrospectively evaluated the clinical outcomes of synchronously diagnosed oligometastatic prostate cancer patients treated with external beam radiation therapy for the prostate and all metastatic lesions (≤3 lesions) at Kyoto University Hospital between January 2004 and April 2019. The prescribed dose was basically ≥70 Gy for the prostate with or without whole pelvic irradiation, and ≥45 Gy for the metastatic lesions. Clinical outcomes were compared with a contemporary cohort of 55 synchronous oligometastatic prostate cancer patients treated with the standard of care.ResultsIn total, 16 consecutive patients with synchronous oligometastatic prostate cancer were analyzed. The median follow‐up period was 7.4 years. The 8‐year overall survival, prostate cancer‐specific survival, biochemical failure‐free, clinical failure‐free and castration‐resistant prostate cancer‐free rates were 64.8%, 71.3%, 38.5%, 47.3% and 67.3%, respectively. No grade 3 or higher radiation‐induced late toxicities occurred. Patients with prostate‐targeted treatment plus metastasis‐directed therapy had a significantly higher castration‐resistant prostate cancer‐free rate than those without prostate‐targeted treatment plus metastasis‐directed therapy (P = 0.00741).ConclusionsProstate‐targeted treatment plus metastasis‐directed therapy through external beam radiation therapy can result in favorable long‐term disease‐free and survival outcomes with acceptable morbidities among synchronous oligometastatic prostate cancer patients. Therefore, this approach may represent a promising treatment strategy for this population. Further investigation is required.
Digital media and international migration: Twitter discourse during the Canadian federal election
Authors: Walsh James P. 
Published: April 2021

AbstractAs a contentious, multidimensional issue, migration attracts significant media attention in affluent societies. While analysts have assessed coverage in traditional outlets, less is known about social media – digital platforms that facilitate the creation and sharing of content online. Working with a unique dataset of tweets from the 2019 Canadian federal election, this study analyses migration's representation within visible digital spaces. Employing content analytic methods, it offers new insight into the patterns of participation, claims‐making and engagement associated with the topic's online depiction. Alongside documenting significant lay involvement and creativity, it reveals communications were slightly negative and, reflecting the contemporary political climate, significantly more likely to feature identity‐based issues than economic and redistributive concerns. Messages from professional broadcasters, as well as, those featuring negative sentiments and referencing cultural matters generated greater engagement. The implications of these results and recommendations for future research are considered.
Mothers and nurses' perceptions of the family‐centered care barriers in pediatric departments of an educational hospital in Iran
Authors: Farokhzadian Jamileh , Forouzi Mansooreh Azizzadeh , Sheikhbardsiri Hojjat 
Published: April 2021

AbstractProblemFamily‐centered care (FCC) is a concept used to describe an approach to caring for children and their families within health services. This study compared mothers and nurses' perceptions of barriers to FCC.MethodsThis cross‐sectional study was conducted in an educational hospital affiliated to Kerman University of Medical Sciences at the southeast of Iran in 2019. Using a researcher‐designed questionnaire, we assessed mothers' and nurses' perceptions of barriers to FCC with a census method (60 nurses and 82 mothers).FindingsMothers (49.8 ± 21.1) and nurses' (49.2 ± 16.4) mean scores of the perception of FCC barriers were at a moderate level. No significant difference was found between mothers' and nurses' perceptions of barriers to FCC. A significant relationship was observed between age, child's admission history, and the perception of FCC barriers in the mothers' group.ConclusionFindings suggest that national and regional policies of educational hospitals should assess factors contributing to the FCC barriers, focus on how to reduce these barriers, and provide appropriate collaborative care by nurses and the family of patients.
Retracted: miR‐365 secreted from M2 Macrophage‐derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis
Authors: Li Xin , Xu Hao , Yi Jianfeng , Dong Chunlu , Zhang Hui , Wang Zhengfeng , Miao Long , Zhou Wence 
Published: April 2021

AbstractClinical and experimental evidence indicates that tumour‐associated macrophages support cancer progression. Moreover, macrophage‐derived extracellular vesicles (EVs) are involved in pathogenesis of multiple cancers, yet the functions of molecular determinants in which have not been fully understood. Herein, we aim to understand whether macrophage modulates pancreatic ductal adenocarcinoma (PDAC) progression in an EV‐dependent manner and the underlying mechanisms. microRNA (miR)‐365 was experimentally determined to be enriched in the EVs from M2 macrophages (M2‐EVs), which could be transferred into PDAC cells. Using a co‐culture system, M2‐EVs could enhance the proliferating, migrating and invading potentials of PDAC cells, while inhibition of miR‐365 in M2‐EVs could repress these malignant functions. B‐cell translocation gene 2 (BTG2) was identified to be a direct target of miR‐365, while the focal adhesion kinase (F/ATP)‐dependent tyrosine kinase (AKT) pathway was activated by miR‐365. We further demonstrated that overexpression of BTG2 could delay the progression of PDAC in vitro, whereas by impairing BTG2‐mediated anti‐tumour effect, M2‐EV‐miR‐365 promoted PDAC progression. For validation, a nude mouse model of tumorigenesis was established, in which we found that targeting M2‐EV‐miR‐365 contributed to suppression of tumour growth. Collectively, M2‐EVs carry miR‐365 to suppress BTG2 expression, which activated FAK/AKT pathway, thus promoting PDAC development.
Potential role of FoxO3a in the regulation of trophoblast development and pregnancy complications
Authors: Chen Hao , Tang Xin , Han Ting‐Li , Zhu Jia‐Nan , Zhou Wei , Baker Philip N. , Chen Chang , Zhang Hua 
Published: April 2021

AbstractThe forkhead box O3a protein (FoxO3a) has been reported to regulate tumour invasion and migration, but little is known about the molecular mechanism or its role in trophoblast invasion and migration into the uterus. In this study, we aim to explore its role in trophoblast development and placenta‐related pregnancy complications and the potential mechanism. Levels of FoxO3a and its phosphorylated form (p‐FoxO3a) in placental tissue from healthy pregnant women and pre‐eclampsia patients were first compared. Then, HTR‐8/SVneo cells were transfected with lentiviral vectors to deplete and overexpress FoxO3a. Western blot, immunohistochemistry, Cell Counting Kit‐8, wound‐healing assay, Matrigel invasion assay, cell apoptosis, cell cycle assay, RNA sequencing, qRT‐PCR and ChIP‐qPCR were performed on the cells to study the potential role of FoxO3a and the underlying mechanism. We found the expression of FoxO3a was decreased, whereas p‐FoxO3a was increased in pre‐eclampsia placentae. FoxO3a depletion significantly reduced transcription of the promoter region of intercellular cell adhesion molecule‐1 (ICAM1) gene in ChIP assays and led to reduced invasion and migration of trophoblast cells, arrested cell cycle in G1 phase and increased apoptosis under oxidative stress. Our results suggested that FoxO3a may play a role in the regulation of trophoblast invasion and migration during placental development, which may be because of its affinity to the ICAM1 promotor.
Scymnodon plunketi (Waite, 1910): a junior synonym of Scymnodon macracanthus (Regan, 1906) (Somniosidae: Elasmobranchii)
Authors: B. Vaz Diego F. 
Published: April 2021

AbstractThe taxonomic status and validity of Scymnodon macracanthus (Regan, 1906) and Scymnodon plunketi (Waite, 1910) are revised in light of new material from the Southern Pacific and Indian Oceans. Despite being historically accepted as distinct taxa, recent studies suggested the possibility that these species could represent a single taxon. Morphometrics, meristics and morphology of dermal denticles show that S. plunketi is indeed a junior synonym of S. macracanthus. Previous distinctive characters proved to be the result of intraspecific variation. S. macracanthus is therefore redescribed including an updated comparative diagnosis for the genus Scymnodon in the family Somniosidae.
Deep genetic and morphological divergence in the Hippopotamyrus ansorgii species complex (Teleostei: Mormyridae) in southern Africa
Authors: Mutizwa Tadiwa I. , Kadye Wilbert T. , Chakona Albert 
Published: April 2021

AbstractThe present study used molecular and morphological approaches to investigate hidden diversity within the Hippopotamyrus ansorgii species complex in southern Africa. Phylogenetic reconstructions and three species delimitation methods based on two mitochondrial markers (cytochrome b and cytochrome oxidase I) and one nuclear marker (S7) revealed 12 Molecular Operational Taxonomic Units (MOTUs), with two of them representing two recently described species, Hippopotamyrus longilateralis and Hippopotamyrus szaboi. The highest diversity occurred in the Kwanza River system, which contained five MOTUs, and the Upper Zambezi River system that had two MOTUs. Five other river systems contained a single MOTU each. A major impediment to the review of this complex has been the uncertainty surrounding the type locality of the specimens that were used for the description of H. ansorgii. The present study has, through a careful examination of published literature and synthesis of information on the travel activities of Dr. William Ansorge who collected the specimens, identified the Kwanza River system as the most plausible source of the syntypes. The resolution of the type locality of H. ansorgii facilitates future work on the review of this complex which is critical for providing reliable biodiversity estimates, identifying effective conservation management strategies and understanding the evolutionary history and biogeographic patterns of the fishes of this region.
Effect of anticoagulants on farmed giant kokopu, Galaxias argenteus (Gmelin 1789) haematological parameters and erythrocyte fragility
Authors: Lulijwa Ronald , Alfaro Andrea C. , Young Tim , Venter Leonie , Decker Paul , Merien Fabrice , Meyer Jill 
Published: April 2021

AbstractWe sought to determine a compatible anticoagulant for routine haematological and physiological assessments with giant kokopu (Galaxias argenteus), an endemic New Zealand fish. We observed that blood treated with lithium heparin (LH) rapidly coagulated and haemolysed, making it unsuitable for G. argenteus. Dipotassium ethylenediaminetetraacetic acid (K2EDTA) and trisodium citrate (citrate) effectively prevented blood coagulation. K2EDTA‐treated erythrocytes exhibited the least mean haemolysis and mean corpuscular fragility. Further studies into prolonged storage effects of citrate and K2EDTA are recommended to find a compatible anticoagulant for use with G. argenteus blood.
A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions
Authors: Wu Clement Chun Ho , Namasivayam Vikneswaran , Li James Weiquan , Khor Chris JL , Fock Kwong Ming , Law Ngai Moh , Wang Lai Mun , Ang Tiing Leong 
Published: April 2021

AbstractBackground and AimGastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow‐band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI.MethodPatients were randomized in a 1:1 ratio to receive tandem gastroscopy with WLI inspection followed by LCI, or vice versa. Endoscopic examination was performed using the EG‐L590ZW gastroscope and the LASEREO endoscope system (Fujifilm Co., Tokyo, Japan). Histology was reported by a specialist GI pathologist blinded to the technique of lesion detection and was used as the gold standard for diagnosis.ResultsNinety patients (mean age 66.8 years, 51.5% male patients) were randomized to either LCI examination first followed by WLI (LCI‐WLI), or vice versa (WLI‐LCI). An 18.9% of gastroscopies in the study were for surveillance of previously known gastric cancer precursors. Ten patients (11.1%) had a history of Helicobacter pylori infection. There was no significant difference in the time taken for examination under LCI (311 ± 96 s) and WLI (342 ± 86 s) (P = 0.700). LCI detection rates were higher than WLI detection rates for gastric cancer precursors such as atrophic gastritis (2.19% vs 0.55%) (P < 0.01) and intestinal metaplasia (19.73% vs 7.67%) (P < 0.01). Both sensitivity (82.74% vs 50.96%) and specificity (98.71% vs 96.10%) of LCI were higher than WLI for detection of upper GI lesions.ConclusionsLinked color imaging had better detection rates, sensitivity, and specificity for detection of upper GI lesions compared with WLI.
Eating habits of children and adolescents during the COVID‐19 pandemic: The impact of social isolation
Authors: Teixeira Michelle Teixeira , Vitorino Raquel Santiago , da Silva Julia Holandino , Raposo Letícia Martins , Aquino Luana Azevedo de , Ribas Simone Augusta 
Published: April 2021

AbstractBackgroundThe social isolation enforced as a result of the new coronavirus (COVID‐19) pandemic may impact families’ lifestyle and eating habits. The present study aimed to assess the behaviour and dietary patterns of Brazilian children and adolescents during the social isolation imposed by the COVID‐19 pandemic.MethodsThe present study was conducted using an online, anonymous cross‐sectional survey with 589 children and 720 adolescents from Brazil during a nationwide social isolation policy. The Mann–Whitney U‐test or the Kruskal–Wallis with the Dunn post‐hoc method and a radar chart were used to compare the weekly consumption of each food by age group and isolation status. p < 0.05 was considered statistically significant. Analyses were conducted using R statistical software, version 4.0.2 (R Foundation for Statisitical Computing).ResultsWe found that isolated families showed breakfast eating habits and the consumption of raw salad, vegetables, beans and soft drinks. Lower‐class isolated families and those from the Northeast region consumed fruits, juices, vegetables and beans less frequently. Compared to children, adolescents were less isolated (p = 0.016), less active (p < 0.001), exposed to longer screen time (p < 0.001), showed an inadequate sleeping pattern (p = 0.002) and were from lower‐class families (p < 0.001).ConclusionsSocial isolation affected the eating habits of children and adolescents. Non‐isolated families presented a lower consumption of healthy food, especially those among the lower class, from Northeast Brazil, as well as adolescents.
TMK4 receptor kinase negatively modulates ABA signaling by phosphorylating ABI2 and enhancing its activity
Authors: Li Lan , Li Bin , Zhu Sirui , Wang Long , Song Limei , Chen Jia , Ming Zhenhua , Liu Xuanming , Li Xiushan , Yu Feng 
Published: April 2021

AbstractIn plants, clade A type 2C protein phosphatases (PP2CAs) have emerged as major players in abscisic acid (ABA)‐regulated stress responses by inhibiting protein kinase activity. However, how different internal and external environmental signals modulate the activity of PP2CAs are not well known. The transmembrane kinase (TMK) protein 4 (TMK4), one member of a previously identified receptor kinase subfamily on the plasma membrane that plays vital roles in plant cell growth, directly interacts with PP2CAs member (ABA‐Insensitive 2, ABI2). tmk4 mutant is hypersensitive to ABA in both ABA‐inhibited seed germination and primary root growth, indicating that TMK4 is a negative regulator in ABA signaling pathway. Further analyses indicate that TMK4 phosphorylates ABI2 at three conserved Ser residues, thus enhancing the activity of ABI2. The phosphorylation‐mimic ABI2S139DS140DS266D can complement but non‐phosphorylated form ABI2S139AS140AS266A cannot complement ABA hypersensitive phenotype of the loss‐of‐function mutant abi1‐2abi2‐2. This study provides a previously unidentified mechanism for positively regulating ABI2 by a plasma membrane protein kinase.
A Knowledge Graph to Understand Nursing Big Data: Case Example for Guidance
Authors: Hussey Pamela , Das Subhashis , Farrell Sharon , Ledger Lorraine , Spencer Anne 
Published: April 2021

AbstractPurposeTo provide a summary of research on ontology development in the Centre of eIntegrated Care at Dublin City University, Ireland.DesignDesign science methods using Open Innovation 2.0.MethodsThis was a co‐participatory study focusing on adoption of health informatics standards and translation of nursing knowledge to advance nursing theory through a nursing knowledge graph (NKG). In this article we outline groundwork research conducted through a focused analysis to advance structural interoperability and to inform integrated care in Ireland. We provide illustrated details on a simple example of initial research available through open access.FindingsFor this phase of development, the initial completed research is presented and discussed.ConclusionsWe conclude by promoting the use of knowledge graphs for visualization of diverse knowledge translation, which can be used as a primer to gain valuable insights into nursing interventions to inform big data science in the future.Clinical RelevanceIn line with stated global policy, the uptake and use of health informatics standards in design science within the profession of nursing is a priority. Nursing leaders should initially focus on health informatics standards relating to structural interoperability to inform development of NKGs. This will provide a robust foundation to gain valuable insights into articulating the nursing contribution in relation to the design of digital health and progress the nursing contribution to targeted data sources for the advancement of United Nations Sustainable Development Goal Three.
A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low‐potency topical corticosteroid in the treatment of intertrigo
Authors: Leeyaphan Charussri , Varothai Supenya , Trakanwittayarak Suphattra , Suphatsathienkul Pranittra , Pattaravadee Suthasinee , Matthapan Lalita , Prasong Waranyoo , Lertrujiwanit Kamonpan , Supcharoenkul Salisa , Kulthanan Kanokvalai 
Published: April 2021

AbstractBackgroundIntertrigo is an inflammatory skin‐fold condition. Candida infections may occur concurrently or afterward. Topical corticosteroids may reduce inflammation but exacerbate Candida infections. The treatment is contentious.ObjectiveTo evaluate the efficacies and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin for the treatment of mild‐to‐moderate intertrigo, relative to 1% hydrocortisone cream.MethodsThis randomized, double‐blinded study enrolled 40 intertrigo patients. Twice daily, 20 patients applied adsorbent lotion while the remainder used 1% hydrocortisone cream. Efficacy evaluation, skin biophysical measurements, skin tolerability, safety, and visual analog scale (VAS) patient‐satisfaction scores were evaluated at baseline and Week 2.ResultsThe adsorbent lotion showed higher complete cure rates for color, partial epidermal loss, papules/pustules/vesicles/patches, dryness, and scaling than the corticosteroid without statistical significance. Adsorbent lotion demonstrated significantly higher reduction in pruritus than the corticosteroid treatment. Reduction of erythema level using Mexameter and VAS patient‐satisfaction scores were not statistically different between adsorbent lotion and hydrocortisone cream. No adverse effects or superimposed infections were reported.ConclusionsThe anti‐inflammatory efficacies of adsorbent lotion and low‐potency steroid were equivalent. The lotion was safe and produced excellent pruritus reduction. Patient satisfaction was high.
Impact of polyphenols extracted from Tricholoma matsutake on UVB‐induced photoaging in mouse skin
Authors: Deng Minggao , Wang Jing , Li Yong‐Liang , Chen Hui‐Xiong , Tai Meiling , Deng Lili , Che Biao , Du Zhi‐Yun , Dong Chang‐Zhi , Lin Li 
Published: April 2021

AbstractBackgroundDespite Tricholoma matsutake has been used as natural health products with multiple medicinal properties, detailed information about its polyphenolic composition as sources of anti‐photoaging agents remains to be determined.ObjectiveTo investigate the impact of polyphenols extracted from Tricholoma matsutake (TME) on Ultraviolet B (UVB)‐induced skin photoaging.Materials and MethodsVarious factors of oxidative stress and inflammation as well as histological and immunohistochemical analysis in the mouse dorsal skin were determined after UVB radiation.ResultsTopical administration with TME suppressed the UVB‐induced skin thickness, wrinkles and erythema, and increased skin collagen content. Furthermore, TME decreased reactive oxygen species (ROS) level, upregulated glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD), catalase (CAT), and glucose‐6‐phosphate dehydrogenase (G6PDH) activities and inhibited the expression of IL‐1, IL‐6, IL‐8, and TNF‐α in mice irradiated with UVB. TME could reduce UVB‐induced p38 mitogen‐activated protein kinase (p38 MAPK) phosphorylation and effectively inhibited the activity of the transcriptional factor nuclear factor‐kappa B (NF‐κB), thereby reducing the cyclooxygenase‐2 (COX‐2) expression, which is an important mediator of inflammatory cascade leading to the inflammatory response.ConclusionOur data demonstrated that TME had various beneficial effects on UVB‐induced skin photoaging due to its antioxidant and anti‐inflammatory activities, and it might be exploited as a promising natural product in skin care, anti‐photoaging and the therapeutic intervention of skin disorders related to both oxidative stress and inflammation.