bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh (Keselamatan dan Kesehatan Kerja) dan Stres Kerja Terhadap Kinerja Karyawan (Studi kasus pada PT. Ridar Essindo di Tangerang)
Authors: Maduningtias Lucia , Khoir Oki Iqbal , Tarwijo Tarwijo 
Published: November 2021

Penelitian bertujuan untuk mengetahui Keselamatan dan Kesehatan Kerja, Stres Kerja Terhadap Kinerja Karyawan. Penelitian ini menggunakan metode deskritif kuantitatif analisis dengan pendekatan survey, kuesioner, dan wawancara. Populasi dalam penelitian ini adalah seluruh karyawan Ridar Essindo yang berjumlah 50 orang dengan menggunakan sampel jenuh. Teknik analisis menggunakan uji validitas, uji reliabilitas, uji normalitas, uji multikolinieritas, uji heteroskedastisitas, analisis regresi linear berganda, koefisien determinasi dan korelasi, uji f, dan uji t. Berdasarkan hasil perhitungan analisis regresi berganda diperoleh Y = 21.096 + 0.645 X1 + 0.099 X2 + 6.205. Hasil uji t menunjukkan bahwa variabel X1 berpengaruh signifikan dilihat dari nilai t-hitung lebih besar dari t-tabel sebesar 4.358 < 1,677 dan nilai signifikasi lebih kecil sebesar 0,000 < 0,05. Sedangkan X2 berpengaruh namun tidak signifikan terhadap kinerja karyawan dilihat dari nilai t-hitung lebih besar dari t-tabel sebesar 0,793 > 1,677 dan nilai signifikasi lebih besar sebesar 0,464 > 0,05. Kemudian melalui uji koefisien determinasi menunjukkan R sebesar 0,533 yang berarti terdapat hubungan yang positif dan kuat antara keselamatan dan kesehatan kerja, stress kerja terhadap kinerja karyawan. Koefisien determinasinya sebesar 0,276. Hal ini menunjukkan sebesar 27,6%, sedangkan 72,4% dipengaruhi oleh faktor lain seperti penempatan karyawan, pelatihan kerja, lingkungan kerja dan lain-lain. Berdasarkan pengujian hipotesis yang telah dilakukan dengan menggunakan uji f diperoleh bahwa fhitung = 27,396 dan setelah dikonsultasikan dengan ftabel pada taraf signifikan 5% dan n = (-3) menunjukkan ftabel = 3,20 yang artinya terdapat pengaruh yang positif antara kesehatan dan keselamatan kerja, stres kerja terhadap kinerja karyawan karena fhitung (27,396) > (3,20).
A praia como lugar de memória e formação de sociabilidades
Authors: Tavares Marcelo Ribeiro , Vaz Lilian Fessler , Matos Madalena Cunha 
Published: November 2021

Introdução: Esporte e espaço urbano formam um binômio singular. A cidade como lugar privilegiado de práticas sociais possui no esporte um uso importante para a produção de memórias e para o fortalecimento de sociabilidades.Metodologia: Inclui revisão de literatura e pesquisa de campo para observação dos eventos, além da aplicação de questionários via ambiente virtual com jogadores amadores e frequentadores da praia.Resultados e discussão: Destaca-se a praia como lugar de diferenciação e conflito, que institui códigos, normas e usos segregados; a praia como lugar de mediações de conflitos advindos da intensidade de usos que são requeridos para esse espaço e a praia como lugar de disputa por espaço, desde atividades de trabalho às atividades de esportes e lazer. Frequentar a praia é um exercício intenso de socialização. Contribuições teórico-metodológicas: Destacar a pesquisa de literatura e de campo como suporte para ações de investigação que tenham a paisagem, a memória e o esporte como temas fundamentais para se pensar o espaço urbano, sobretudo, em lugares onde há uso de lazer ao longo do tempo.Conclusões: Verifica-se que a praia é um lugar onde conflitos e disputas por espaço se dão de forma intensa, mas a sociabilidade que se forma em torno de um ambiente tão agradável e voltado para atividades lúdicas e de lazer torna-se também uma marca da identidade carioca. Copacabana é uma referência mundial para a prática do vôlei, sede de campeonatos internacionais e das Olimpíadas de 2016. Assim, a orla é um espaço público importante como lugar de lazer e sociabilidade em meio urbano.
FAD-Linked Autofluorescence and Chemically-Evoked Zinc Changes at Hippocampal Mossy Fiber-CA3 Synapses
Authors: M.C. Bastos Fatima , M. Matias Carlos , O. Lopes Ines , P. Vieira João , M. Santos Rosa , M. Rosario Luis , M. Quinta-Ferreira Rosa , Emilia Quinta-Ferreira Maria 
Published: November 2021

Glutamatergic vesicles in hippocampal mossy fiber presynaptic boutons release zinc, which plays a modulatory role in synaptic activity and LTP. In this work, a fluorescence microscopy technique and the fluorescent probe for cytosolic zinc, Newport Green (NG), were applied, in a combined study of autofluorescence and zinc changes at the hippocampal mossy fiber-CA3 synaptic system. In particular, the dynamics of flavoprotein (FAD) autofluorescence signals, was compared to that of postsynaptic zinc signals, elicited both by high K+ (20 mM) and by tetraethylammonium (TEA, 25 mM). The real zinc signals were obtained subtracting autofluorescence values, from corresponding total NG-fluorescence data. Both autofluorescence and zinc-related fluorescence were raised by high K+. In contrast, the same signals were reduced during TEA exposure. It is suggested that the initial outburst of TEA-evoked zinc release might activate ATP-sensitive K+ (KATP) channels, as part of a safeguard mechanism against excessive glutamatergic action. This would cause sustained inhibition of zinc signals and a more reduced mitochondrial state. In favor of the “KATP channel hypothesis”, the KATP channel blocker tolbutamide (250 μM) nearly suppressed the TEA-evoked fluorescence changes. It is concluded that recording autofluorescence from brain slices is essential for the accurate assessment of zinc signals and actions.
Low Etanercept Concentrations in Children With Obesity and Juvenile Idiopathic Arthritis
Authors: Balevic Stephen J. , Becker Mara L. , Gonzalez Daniel , Funk Ryan S. 
Published: November 2021

OBJECTIVE
To evaluate the impact of obesity on etanercept (ETN) drug exposure in children with juvenile idiopathic arthritis (JIA).

METHODS
We conducted a pilot, cross-sectional, observational study in a real-world cohort of children with JIA receiving ETN as standard of care from a single center. We analyzed the relationship between body size and ETN plasma concentrations, adjusting for dosage. Body size was analyzed as a continuous measure using weight and body mass index (BMI) percentiles and categorically using BMI percentile classifications according to the CDC guidelines.

RESULTS
We enrolled a total of 29 children. Each child provided one plasma sample for ETN concentration measurement, and all participants were receiving subcutaneous ETN dosed weekly. We observed that the ETN concentration normalized for dose decreased significantly as a function of weight (p = 0.004) and BMI percentile (p = 0.04). Similarly, we observed a progressive decline in mean and median dose-normalized concentrations across higher body size categories. Because of reaching maximum ETN dosage (50 mg), 7 of 8 children (87.5%) with obesity received a weight-based dosage &lt; 0.8 mg/kg/dose.

CONCLUSIONS
We found that higher body weight and BMI percentile are significantly and negatively associated with ETN drug serum concentration, accounting for differences in dosing. Our data suggest that children who are obese may be routinely under-dosed using current dosing strategies. Inadequate dosing may increase the risk for therapeutic failure and long-term morbidity in a developing child. As a result, characterizing adequate drug exposure in children of all sizes is an important step toward precision dosing.
Transaktionsomkostninger i frivillige sociale organisationer
Authors: Clausen Mads Roke 
Published: November 2021

Stigende brug af målrettede sociale investeringer har medført en relevant forskningsmæssig interesse for transaktionsomkostninger i sociale indsatser. Men hovedparten af forskningen er præget af to udfordringer: Dels at analyserne oftest begrænser sig til offentlige indtægtskilder og således udelader private kilder, dels at transaktionsomkostningerne måles ud fra selvdeklarerede oplysninger om administrative omkostninger.
Denne artikel bidrager til forskningsfeltet på to måder. For det første med en analysemodel, der samler private og offentlige indtægtskilder i én model, hvilket giver en unik mulighed for at sammenligne transaktionsomkostningerne fra disse to kilder. For det andet måles transaktionsomkostninger ud fra den faktiske udvikling i antallet af administrative akademiske årsværk i organisationerne. Derved opnås også en bedre kobling til teorien på området, som fokuserer på netop administrative medarbejdere.
Artiklens datagrundlag udgøres af et paneldatasæt for perioden 2012-17 med regnskabsoplysninger om indtægter i de landsdækkende frivillige sociale organisationer samt registeroplysninger fra Danmarks Statistik om medarbejderes uddannelse og timetal i de samme organisationer. Det vises, at målrettede projektmidler fra private kilder medfører markant højere transaktionsomkostninger end både statslige projektmidler og faste offentlige bevillinger, og at mindre organisationer generelt har højere omkostninger ved at skaffe finansiering end større organisationer med stordriftsfordele.
Upcycle Limbah Kayu Palet Jati Belanda Menjadi Wadah Modular Serbaguna untuk Anak-Anak (Studi Kasus: Kota Surabaya)
Authors: Sutanto Jessica , Gede P Cok , E.D. Tedjokoesoemo Purnama 
Published: November 2021

Anak-anak memiliki kebutuhan yang terus meningkat seperti buku, baju, dan sepatu. Kebutuhan yang berbeda dari setiap anak menyebabkan wadah yang sifatnya dapat ditambahkan sesuai kebutuhan serta memiliki fleksibilitas yang tinggi dapat dilihat sebagai solusi yang tepat. Momot sebagai wadah modular dengan memanfaatkan limbah palet Jati Belanda dihadirkan sebagai solusi atas masalah di atas. Kayu palet Jati Belanda memiliki carbon footprint lebih kecil dibanding dengan material lainnya seperti, plastik, logam, dan beton sehingga limbahnya dapat dimanfaatkan kembali tanpa merugikan lingkungan. Selain itu, sosialisasi green lifestyle dapat dimulai dari usia dini yaitu, usia 6-12 tahun agar anak menjadi lebih peka dan bertanggung jawab terhadap lingkungan. Pendekatan pemanfaatan limbah yang digunakan dalam perancangan ini adalah upcycle. Proses perancangannya menggunakan metode kualitatif yang berlangsung dalam enam tahap yaitu, discovery -interpretation – ideation – experimentation – evolution - implementation. Perancangan mebel knockdown ini dibuat dalam bentuk modular dengan sambungan dasar mortise dan tenon.
Why do habitual violent video game players believe in the cathartic effects of violent video games? A misinterpretation of mood improvement as a reduction in aggressive feelings
Authors: Kersten Riccarda , Greitemeyer Tobias 
Published: November 2021

AbstractPrevious research found that violent video game play leads to increased aggression, but many people (mainly habitual violent video game players) still believe that playing violent games releases aggressive feelings and in turn reduces aggressive behavior. Other research has shown that video game play can have a positive impact on the player's mood. Based on the General Aggression Model and mood management theory, we thus hypothesized that habitual violent video game players misinterpret their better mood after game play as a reduction of aggressive feelings and hence believe in the cathartic effects of violent video games. Two studies examined this reasoning in the player's natural habitat. Habitual video game players were surveyed multiple times for a period of 2 weeks before and after each gaming session. Results showed that playing video games improved the participant's mood, which in turn was positively associated with the belief in the cathartic effect of violent video game play. Importantly, this relation held when controlling for the player's actual level of aggressive feelings. Study 1 further showed that playing a violent game tended to lead to a higher level of reported aggressive feelings after playing. In contrast, in Study 2, level of reported aggressive feelings was not related to the violence of the game. Taken together, habitual violent video game players (erroneously) believe in the cathartic effects of violent video games, because they are in a better mood after playing.
An Autonomous Molecular Bioluminescent Reporter (AMBER) for Voltage Imaging in Freely Moving Animals
Authors: Srinivasan Prasanna , Griffin Nicole M , Thakur DhananjayP. , Joshi PradeepM. , Nguyen‐Le Alex , McCotter Sean , Jain Akshar , Saeidi Mitra , Kulkarni Prajakta , Eisdorfer Jaclyn T. , Rothman Joel H. , Montell Craig , Theogarajan Luke 
Published: November 2021

AbstractGenetically encoded reporters have greatly increased our understanding of biology. While fluorescent reporters have been widely used, photostability and phototoxicity have hindered their use in long‐term experiments. Bioluminescence overcomes some of these challenges but requires the addition of an exogenous luciferin limiting its use. Using a modular approach, Autonomous Molecular BioluminEscent Reporter (AMBER), an indicator of membrane potential is engineered. Unlike other bioluminescent systems, AMBER is a voltage‐gated luciferase coupling the functionalities of the Ciona voltage‐sensing domain (VSD) and bacterial luciferase, luxAB. When co‐expressed with the luciferin‐producing genes, AMBER reversibly switches the bioluminescent intensity as a function of membrane potential. Using biophysical and biochemical methods, it is shown that AMBER switches its enzymatic activity from an OFF to an ON state as a function of the membrane potential. Upon depolarization, AMBER switches from a low to a high enzymatic activity state, showing a several‐fold increase in the bioluminescence output (ΔL/L). AMBER in the pharyngeal muscles and mechanosensory touch neurons of Caenorhabditis elegans is expressed. Using the compressed sensing approach, the electropharingeogram of the C. elegans pharynx is reconstructed, validating the sensor in vivo. Thus, AMBER represents the first fully genetically encoded bioluminescent reporter without requiring exogenous luciferin addition.
Viscoelastic Response of Graphene Oxide‐Based Membranes and Efficient Broadband Sound Transduction
Authors: Hu Kaiwen , Cardenas William , Huang Yi‐Chi , Wei Huijing , Gaskell Robert‐Eric , Martel Eli , Cerruti Marta , Szkopek Thomas 
Published: November 2021

AbstractFreestanding micrometer thick graphene oxide (GO) membranes combine high stiffness, low mass density, and high loss coefficient. This unique combination of properties is ideal for efficient and broadband electro‐acoustic transduction, relying on membrane lightness, stiffness, and internal damping. Here, the viscoelastic response of GO membranes is measured, and the application of ≈100 µm thick GO membranes is demonstrated in dynamic loudspeakers. Using dynamic mechanical analysis and the time‐temperature superposition principle of polymer rheology, it is found that the stiffness of GO membrane increases by more than 50% over 1–20 kHz while damping decreases by less than 20%. GO membranes exhibit 45% higher damping than aluminum membranes in loudspeakers assemblies. Consequently, GO membranes enable the upshift of loudspeaker breakup frequency by octave above speakers assembled with aluminum, polyethylene terephthalate, titanium, and oak wood membranes. GO is thus found to be an exceptional material for electro‐acoustic transduction.
Structural Engineering in Graphite‐Based Metal‐Ion Batteries
Authors: Luo Pan , Zheng Cheng , He Jiawei , Tu Xin , Sun Wenping , Pan Hongge , Zhou Yanping , Rui Xianhong , Zhang Bing , Huang Kama 
Published: November 2021

AbstractGraphite‐derived carbon materials have been widely used in metal‐ion batteries due to their good mechanical and electrical properties, cost effectiveness, light weight, and environmental friendliness. Though natural graphite has been commercially used in lithium‐ion batteries, the small interlayer spacing hinders its application in other metal‐ion batteries. As such, numerous works have been done to enhance the metal‐ion storage capability of graphite and its derivatives. In this review, structural engineering on graphite including expanded graphite, graphite intercalation compounds and porous graphite, and the corresponding electrolyte engineering for lithium‐ion batteries, sodium ion batteries, potassium ion batteries, and dual ion batteries are summarized, aiming to make a comparison between various strategies and give a suggestion on future work in this area.
An Annealing Accelerator for Ising Spin Systems Based on In‐Memory Complementary 2D FETs
Authors: Sebastian Amritanand , Das Sarbashis , Das Saptarshi 
Published: November 2021

AbstractMetaheuristic algorithms such as simulated annealing (SA) are often implemented for optimization in combinatorial problems, especially for discreet problems. SA employs a stochastic search, where high‐energy transitions (“hill‐climbing”) are allowed with a temperature‐dependent probability to escape local optima. Ising spin glass systems have properties such as spin disorder and “frustration” and provide a discreet combinatorial problem with a high number of metastable states and ground‐state degeneracy. In this work, subthreshold Boltzmann transport is exploited in complementary 2D field‐effect transistors (p‐type WSe2 and n‐type MoS2) integrated with an analog, nonvolatile, and programmable floating‐gate memory stack to develop in‐memory computing primitives necessary for energy‐ and area‐efficient hardware acceleration of SA for Ising spin systems. Search acceleration of >800× is demonstrated for 4 × 4 ferromagnetic, antiferromagnetic, and spin glass systems using SA compared to an exhaustive search using a brute force trial at miniscule total energy expenditure of ≈120 nJ. The hardware‐realistic numerical simulations further highlight the astounding benefits of SA in accelerating the search for larger spin lattices.
Probing Electronic States in Monolayer Semiconductors through Static and Transient Third‐Harmonic Spectroscopies
Authors: Wang Yadong , Iyikanat Fadil , Rostami Habib , Bai Xueyin , Hu Xuerong , Das Susobhan , Dai Yunyun , Du Luojun , Zhang Yi , Li Shisheng , Lipsanen Harri , García de Abajo F. Javier , Sun Zhipei 
Published: November 2021

AbstractElectronic states and their dynamics are of critical importance for electronic and optoelectronic applications. Here, various relevant electronic states in monolayer MoS2, such as multiple excitonic Rydberg states and free‐particle energy bands are probed with a high relative contrast of up to ≥200 via broadband (from ≈1.79 to 3.10 eV) static third‐harmonic spectroscopy (THS), which is further supported by theoretical calculations. Moreover, transient THS is introduced to demonstrate that third‐harmonic generation can be all‐optically modulated with a modulation depth exceeding ≈94% at ≈2.18 eV, providing direct evidence of dominant carrier relaxation processes associated with carrier–exciton and carrier–phonon interactions. The results indicate that static and transient THS are not only promising techniques for the characterization of monolayer semiconductors and their heterostructures, but also a potential platform for disruptive photonic and optoelectronic applications, including all‐optical modulation and imaging.
Polymeric Hydrogels—A Promising Platform in Enhancing Water Security for a Sustainable Future
Authors: Loo Siew‐Leng , Vásquez Lía , Athanassiou Athanassia , Fragouli Despina 
Published: November 2021

AbstractAlthough water is essential for global health and the socio‐economic development of modern society, providing fresh water universally in a sustainable and affordable manner, for both developing and industrialized communities, is challenging. Polymeric hydrogels have recently drawn increasing interest as promising material platforms to sustainably enhance global water security. This review aims to provide a consolidated overview of polymeric hydrogels as an enabling agent in various water treatment technologies. First, a summary of the different approaches for the preparation of hydrogels with tailored chemistry, morphology, structure, and functions that enable the multifaceted requirements of different water technologies to be met is presented. Then, a set of properties unique to hydrogels, which gives them competitive advantages compared to other materials in the context of water treatment, is presented and discussed. This is followed by a comprehensive review of the applications of hydrogels in different water technologies. Their performance is correlated to their unique properties in order to gain an in‐depth mechanistic understanding of how hydrogels can lead to impressive performance and technological innovation. The authors conclude with some proposed solutions and recommendations for prospective research directions to address the remaining challenges specific to each hydrogel‐enabled water technology.
Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
Authors: Cao Man , Wang Shan , Hu Jia‐Hua , Lu Bing‐Huai , Wang Qian‐You , Zang Shuang‐Quan 
Published: November 2021

AbstractSuperbugs are bacteria that have grown resistant to most antibiotics, seriously threating the health of people. Silver (Ag) nanoparticles are known to exert a wide‐spectrum antimicrobial property, yet remains challenging against superbugs. Here, Ag clusters are assembled using porphyrin‐based linkers and a novel framework structure (Ag9‐AgTPyP) is produced, in which nine‐nuclearity Ag9 clusters are uniformly separated by Ag‐centered porphyrin units (AgTPyP) in two dimensions, demonstrating open permeant porosity. Ag9‐AgTPyP eliminates over 99.99999% and 99.999% methicillin‐resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) within 2 h upon visible‐light irradiation, which are superior to a majority of bacteria inactivation photocatalysts. The novel‐established long‐term charge‐transfer states from AgTPyP to adjacent Ag9 cluster that has preferential affinity to O2 greatly promote reactive oxygen species (ROS) production efficiency; and its unique framework accelerates the ROS transportation. Personal protective equipment (masks and protective suits) incorporating Ag9‐AgTPyP film also shows excellent performances against superbugs. This superbugs‐killing efficiency is unprecedented among silver complexes and porphyrin derivatives. Utilizing efficient photogenerated electrons and holes between metal cluster and linkers can open up new interests of research in photocatalytic areas.
Research Progress on the Relationship Between Inflammation and Colorectal Cancer
Authors: Zhang Feng , Qiao Song 
Published: November 2021

AbstractColorectal cancer is one of the common malignant tumors. Relevant epidemiology and a large number of experimental studies have proved that chronic inflammation is highly correlated with the occurrence and development of colorectal cancer. And inflammatory bowel disease has been proven to be an independent risk factor for colorectal cancer. Various inflammatory cells participate in the establishment of the chronic inflammatory intestinal microenvironment required for the onset of colorectal cancer. The abnormal signal pathways mediated by various inflammatory factors and inflammatory mediators promote the occurrence of tumors, which are related to colorectal cancer and pathogenesis‐related inflammation mechanisms. At the gene level, miRNAs can also affect the pathogenesis of colorectal cancer by regulating mesenchymal epithelial transformation. This article reviews the relationship between inflammation and colorectal cancer as well as the related inflammatory mechanisms.