bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-model Subseasonal Precipitation Forecasts over the Contiguous United States: Skill Assessment and Statistical Postprocessing
Authors: Li Yanzhong , Tian Di , Medina Hanoi 
Published: July 2021

AbstractThis study assessed multi-model subseasonal precipitation forecasts (SPFs) from eight subseasonal experiment (SubX) models over the contiguous United States (CONUS) and explored the generalized extreme value distribution (GEV)-based ensemble model output statistics (EMOS) framework for postprocessing multi-model ensemble SPF. The results showed that the SubX SPF skill varied by location and season, and the skill were relatively high in the western coastal region, north-central region, and Florida peninsula. The forecast skill was higher during winter than summer seasons, especially for lead week 3 in the northwest region. While no individual model consistently outperformed the others, the simple multi-model ensemble (MME) demonstrated a higher skill than any individual model. The GEV-based EMOS approach dramatically improved the MME subseasonal precipitation forecast skill at long lead times. The continuous ranked probability score (CRPS) was improved by approximately 20% in week 3 and 43% in lead week 4; the 5-mm Brier skill score (BSS) was improved by 59.2% in lead week 3 and 50.9% in lead week 4, with the largest improvements occurring in the northwestern, north-central, and southeastern CONUS. Regarding the relative contributions of the individual SubX model to the predictive skill, the NCEP model was given the highest weight at the shortest lead time, but the weight decreased dramatically with the increase in lead time, while the CESM, EMC, NCEP, and GMAO models were given approximately equal weights for lead weeks 2-4. The presence of active MJO conditions notably increased the forecast skill in the north-central region during weeks 3-4, while the ENSO phases influenced the skill mostly in the southern regions.
Flexible endoscopy versus direct laryngoscopy for localising impacted pharyngeal foreign bodies in emergency department: A randomised cross‐over manikin pilot study
Authors: Sin Chi‐Kit , Young Bun 
Published: July 2021

Background:Direct laryngoscopy is often poorly tolerated in patients with foreign body ingestion. The use of flexible endoscopes, which are reported to be better tolerated, was described. However, studies on endoscopy usage by emergency physicians are lacking.Objective:This study evaluates whether using a bronchoscope is as effective as the direct laryngoscopy for localising pharyngeal foreign bodies by emergency physicians.Methods:This was a randomised cross‐over manikin study conducted on 32 emergency physicians. Four foreign bodies were placed at the oropharynx, vallecula, arytenoid and post‐cricoid area of a manikin. Participants, being randomised into two groups, examined the pharynx with a bronchoscope and a direct laryngoscope in designated orders. The primary outcome was the complete visualisation rate defined as visualising all the four foreign bodies within the time limit. Secondary outcomes included participants‐rated difficulty scores, device preferences, the time needed for complete visualisation and cumulative success rates.Results:Complete visualisation rate was significantly higher using the bronchoscope (93.8%) than the direct laryngoscope (62.5%) p = 0.02. The overall difficulty score was lower using the bronchoscope (median 4, interquartile range: 3–5) than the direct laryngoscope (median 6, interquartile range: 5–8), p < 0.001. The bronchoscope was the preferred method for overall examination (71.9%) over the direct laryngoscope (28.1%), p = 0.001. There were no significant differences in times needed for complete examination for the bronchoscope (median 73.6 s, interquartile range: 54.7–97.7 s) and the direct laryngoscope (median 82.2 s, interquartile range: 40.1–120 s), p = 0.9, and cumulative success rates, p = 0.081.Conclusion:The bronchoscope was associated with an increased complete visualisation rate and was the easier and preferred method for pharyngeal examination.
Concordance of recommendations across clinical practice guidelines for the management of hypertension in Southeast Asia with internationally reputable sources
Authors: Kow Chia Siang , Hasan Syed Shahzad , Wong Pei Se , Verma Rohit Kumar 
Published: July 2021

AbstractObjectivesThis study aimed to assess the rate of concordance, and to investigate sources of non-concordance of recommendations in the management of hypertension across CPGs in Southeast Asia, with internationally reputable clinical practice guidelines (CPGs).MethodsCPGs for the management of hypertension in Southeast Asia were retrieved from the websites of the Ministry of Health or cardiovascular specialty societies of the individual countries of Southeast Asia during November to December 2020. The recommendations for the management of hypertension specified in the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guideline and the 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guideline were selected to be the reference standards; the recommendations concerning the management of hypertension in the included CPGs in Southeast Asia were assessed if they were concordant with the reference recommendations generated from both the 2017 ACC/AHA guideline and the 2018 ESC/ESH guideline, using the population (P)-intervention (I)-comparison (C) combinations approach.ResultsA total of 59 reference recommendations with unique and unambiguous P-I-C specifications was generated from the 2017 ACC/AHA guideline. In addition, a total of 51 reference recommendations with unique and unambiguous P-I-C specifications was generated from the 2018 ESC/ESH guideline. Considering the six included CPGs from Southeast Asia, concordance was observed for 30 reference recommendations (50.8%) out of 59 reference recommendations generated from the 2017 ACC/AHA guideline and for 31 reference recommendations (69.8%) out of 51 reference recommendations derived from the 2018 ESC/ESH guideline.ConclusionsHypertension represents a significant issue that places health and economic strains in Southeast Asia and demands guideline-based care, yet CPGs in Southeast Asia have a high rate of non-concordance with internationally reputable CPGs. Concordant recommendations could perhaps be considered a standard of care for hypertension management in the Southeast Asia region.
Symptoms of anxiety/depression during the COVID-19 pandemic and associated lockdown in the community: longitudinal data from the TEMPO cohort in France
Authors: Andersen Astrid Juhl , Mary-Krause Murielle , Bustamante Joel José Herranz , Héron Mégane , El Aarbaoui Tarik , Melchior Maria 
Published: July 2021

Abstract
Background
To cope with the COVID-19 pandemic, social distancing restrictions where implemented in France, which could have led to social isolation. This is expected to have affected the mental health situation, including increasing risk of symptoms of anxiety and depression in the general population. Persons with prior mental health difficulties could be an especially vulnerable group, however, few studies have tested this empirically considering preexisting mental health difficulties. We examine the association between preexisting symptoms of anxiety/depression and anxiety/depression during lockdown due to the COVID-19 pandemic in a longitudinal community sample.

Methods
A longitudinal follow-up during lockdown (data collection March–June 2020) was implemented among participants of the TEMPO cohort. Prior knowledge of anxiety/depression was included from prior waves of data collection. Generalized estimation equations models were used to estimate the association between preexisting symptoms of anxiety/depression and symptoms of anxiety/depression during lockdown among 662 mid-aged individuals.

Results
Individuals with symptoms of anxiety/depression measured prior to lockdown had 6.73 higher odds [95% CI = 4.45–10.17] of symptoms of anxiety/depression during lockdown. Additionally, the likelihood of symptoms of anxiety/depression during lockdown was elevated among women (OR = 2.07 [95% CI = 1.32–3.25]), subjects with low household income (OR = 2.28 [1.29–4.01]) and persons who reported being lonely (OR = 3.94 [95% CI = 2.47–6.28]).

Conclusions
Our study underlines the role of preexisting symptoms of anxiety/depression as a vulnerability factor of anxiety/depression during lockdown. Interventions focusing on individuals with mental health difficulties as well as people feeling lonely should be considered, to reduce the psychological impact of the COVID-19 pandemic.
Non-adherence to preventive behaviours during the COVID-19 epidemic: findings from a community study
Authors: Urbán Róbert , Paksi Borbála , Miklósi Ádám , Saunders John B. , Demetrovics Zsolt 
Published: July 2021

Abstract
Backgrounds
Preventive behaviours are an essential way to slow down and eliminate the transmission of SARS-CoV-2. The aim of this study was to estimate adherence to preventive behaviors and to identify whether any subgroups were not adopting these behaviours and for whom greater engagement in these approaches was indicated.

Methods
In this cross-sectional study, we obtained data from a random sample of a panel representing men and women of adult age residing in Hungary (N = 5254). The survey included questions about the frequencies of preventive behaviours, perceived susceptibility and severity of COVID-19.

Results
We found four factors of preventive behaviours: using physical barriers (mask and gloves), avoidance of close contacts, personal hygiene, and preparation. We identified two broadly adherent groups (36.8 and 45.3%) and two non-adherent groups (13.1 and 4.8%). Being male and being aged between 18 and 29 years were the strongest predictors of non-adherence. Concern about the severity of COVID-19 was a predictor of adherence.

Conclusions
To ensure maximal adherence to preventive behaviours for COVID-19, additional strategies should focus on their adoption by men and young adults.
Uptake and correlates of chlamydia and gonorrhea testing among female sex workers in Southern China: a cross-sectional study
Authors: Zhao Pei Zhen , Wang Ya Jie , Cheng Huan Huan , Zhang Ye , Tang Wei Ming , Yang Fan , Zhang Wei , Zhou Ji Yuan , Wang Cheng 
Published: July 2021

Abstract
Background
Female sex workers (FSW) are highly susceptible to chlamydia and gonorrhea infection. However, there is limited literature examining their testing uptake to date. This study aimed to assess the uptake and determinants of chlamydia and gonorrhea testing among FSW in Southern China.

Methods
A cross-sectional study with convenience sampling was performed in five cities in Southern China. Data on socio-demographic characteristics, sexual behaviors, chlamydia and gonorrhea testing, and the utilization of health care services from participants were collected through face-to-face interviews. Univariate and multivariable logistic regressions were used to determine factors associated with chlamydia and gonorrhea testing, respectively.

Results
Overall, 1207 FSWs were recruited, with the mean age of 30.7 ± 6.8 years and an average number of clients of 7.0 (4.0–10.0) per week. 65.4% participants constantly used condoms with clients during the past month. Only 7.5 and 10.4% had been tested for chlamydia and gonorrhea in the last year, respectively. Multivariable analysis indicated that FSW who worked at low tiers (adjusted Odds Ratio (aOR) = 2.36, 95%CI:1.23–10.14), had more clients in the last month (aOR = 1.03, 95%CI:1.01–1.05), used condoms consistently (aOR = 1.79, 95%CI:1.12–2.86), had STD symptoms (aOR = 4.09,95%CI:2.62–6.40), had been tested for HIV (aOR = 5.16, 95%CI:3.21–8.30) or syphilis (aOR = 6.90, 95%CI:4.21–11.22) in the last year were more likely to have chlamydia testing. In addition, FSW who had more clients in the past month (aOR = 1.02,95%CI:1.00–1.04), had STD symptoms (aOR = 3.33, 95%CI:2.03–5.46), had been tested for HIV (aOR = 3.94, 95%CI:2.34–6.65) and syphilis (aOR = 3.27, 95%CI:1.96–5.46) in the last year were more likely to have gonorrhea testing.

Conclusions
The testing rates of chlamydia and gonorrhea are low among Chinese FSW. Integrating chlamydia and gonorrhea testing into HIV testing promotion programs may help bridge the gap among FSW.
Development of a competency for professional oral hygiene care of endotracheally-intubated patients in the intensive care unit: development and validity evidence
Authors: Choi Eun-Sil , Noh Hie-Jin , Chung Won-Gyun , Mun So-Jung 
Published: July 2021

Abstract
Background
Professional oral care in the intensive care unit may reduce the incidence of Ventilator Associated Pneumonia, which increases the patient’s mortality rate. This study aimed to develop a competency for professional oral hygiene care of endotracheally-intubated intensive-care patients.

Methods
First, we developed a competency draft by reviewing the literature on oral hygiene care of patients in the intensive care unit. Next, we developed expert validity test questionnaires using this draft and conducted expert validity tests twice on 18 experts. We determined competency as a content validity index of 0.8 or more and received expert additive opinions about competency through an open-questionnaire expert validity test paper in this methodology study.

Results
The content validity index ranged from 0.8 ~ 1.0 for all items. The competency of ‘professionalism’ comprised 2 sub-competencies with 7 behavioral indicators. ‘POHC preparation’ comprised 3 sub-competencies with 10 behavioral indicators. ‘POHC implementation’ comprised 3 sub-competencies with 6 behavioral indicators. ‘POHC evaluation’ comprised 2 sub-competencies with 8 behavioral indicators. Lastly ‘Cooperation among experts’ comprised 3 sub-competencies with 7 behavioral indicatiors.

Conclusions
To provide patients with high quality oral hygiene care, these competencies should be implemented, and oral hygiene care professionals and related medical personnel should form a cooperative system.
Anthropometric indices and the risk of incident sudden cardiac death among adults with and without diabetes: over 15 years of follow-up in The Tehran Lipid and Glucose Study
Authors: Moazzeni Seyyed Saeed , Tamehri Zadeh Seyed Saeed , Asgari Samaneh , Azizi Fereidoun , Hadaegh Farzad 
Published: July 2021

Abstract
Background
We investigated the association of anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and hip circumference (HC) with the risk of incident sudden cardiac death (SCD) among Iranian population with and without type 2 diabetes mellitus (T2DM).

Methods
The study population included 9,089 subjects without and 1,185 subjects with T2DM, aged ≥ 20 years. Participants were recruited in 1999–2001 or 2001–2005, and followed for incident SCD annually, up to 20 March 2018. Multivariate Cox proportional hazard models, adjusted for traditional risk factors of cardiovascular disease, were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of anthropometric indices (as continuous and categorical variables).

Results
During a follow-up of over 15 years, 144 (1.58%) and 86 (7.26%) incident SCD occurred in non-T2DM and T2DM groups, respectively.
Among non-T2DM group, a 1 standard deviation (SD) increase in WHtR was associated with higher risk of incident SCD by a HR of 1.23 (95% CI: 1.00–1.50) in the multivariable model. From the first quartile to the fourth quartile of WHtR, the trend of SCD risk was significant in age- and sex-adjusted analysis (P-value for trend: 0.041). Other indices did not show significant associations with SCD.
Among T2DM group, a 1 SD increase in WHR had a HR of 1.36 (1.05–1.76) in the multivariable model. Considering WHR as categorical variables, the trend of SCD risk across quartiles of WHR was significant. Furthermore, a 1 SD increase in HC led to reduced risk of incident SCD with a HR of 0.75 (0.58–0.97) in multivariable analysis; this lower risk remained significant even after adjustment for WC. Compared to the first quartile, the fourth quartile of HC also showed a HR of 0.50 (0.25–0.99) (P-value for trend = 0.018). BMI, WC, and WHtR did not have significant associations with incident SCD.

Conclusion
In our long-term population-based study, we demonstrated central but not general obesity (as assessed by WHR in participants with T2DM, and WHtR in participants without T2DM) as a herald of incident SCD. Moreover, HC can have an inverse association with SCD among participants with T2DM.
A new semismooth Newton method for solving finite-dimensional quasi-variational inequalities
Authors: Xie Shui-Lian , Sun Zhe , Xu Hong-Ru 
Published: July 2021

AbstractIn this paper, we consider the numerical method for solving finite-dimensional quasi-variational inequalities with both equality and inequality constraints. Firstly, we present a semismooth equation reformulation to the KKT system of a finite-dimensional quasi-variational inequality. Then we propose a semismooth Newton method to solve the equations and establish its global convergence. Finally, we report some numerical results to show the efficiency of the proposed method. Our method can obtain the solution to some problems that cannot be solved by the method proposed in (Facchinei et al. in Comput. Optim. Appl. 62:85–109, 2015). Besides, our method outperforms than the interior point method proposed in (Facchinei et al. in Math. Program. 144:369–412, 2014).
Relation of therapies for ankylosing spondylitis and psoriatic arthritis to risk of myocardial infarction: a nested case control study
Authors: Stovall Rachael , Peloquin Christine , Felson David , Neogi Tuhina , Dubreuil Maureen 
Published: July 2021

AbstractBackgroundRisk of myocardial infarction (MI) is elevated in ankylosing spondylitis and psoriatic arthritis (AS/PsA) compared to the general population. We evaluated the risk of MI related to the use of tumor necrosis factor inhibitor (TNFi) and other therapies in AS/PsA.MethodsWe conducted a nested case-control study using 1994–2018 data from OptumLabs® Data Warehouse, which includes de-identified medical and pharmacy claims, laboratory results, and enrollment records for commercial and Medicare Advantage enrollees. The database contains longitudinal health information on enrollees and patients, representing a diverse mixture of ages, ethnicities and geographical regions across the United States. Assessing AS/PsA separately, MI cases were matched to 4 controls by sex, age, diagnosis year and insurance type. We evaluated treatment within 6 months prior to MI including NSAIDs (AS referent), disease-modifying anti-rheumatic drug (DMARDs; PsA referent) and TNFi alone or in combinations. We evaluated the relation of treatment categories to MI risk using conditional logistical regression adjusting for confounders.ResultsAmong 26,648 AS subjects, there were 237 MI cases and 894 matched controls. Among 43,734 PsA subjects, there were 404 cases and 1596 controls. In AS, relative to NSAID use, the adjusted odds ratio (aOR) for MI among TNFi only users was 0.85 (95% CI 0.39–1.85) and for DMARD only users was 1.04 (95% CI 0.65–1.68). In PsA, relative to DMARD use, the aOR among TNFi only was 1.09 (95% CI 0.74–1.60). Combination therapies also had no effect.ConclusionsAmong AS/PsA, no combination of therapies appeared to be protective or harmful with regards to MI. Future studies should capture more AS and PsA patients and include longer term follow up to further investigate this question.
Indigenous Record Keeping and Hacienda Culture in the Andes: Modern Khipu Accounting on the Island of the Sun, Bolivia
Authors: Hyland Sabine , Lee Christine 
Published: July 2021

AbstractHow did khipus—knotted cords that encode information—function within the economic systems of the postcolonial Andes? Best known as the method by which the Incas recorded administrative data, khipu use continued into the nineteenth and twentieth centuries. Few studies of modern khipus, however, have analyzed how khipu cords were integrated with the institutions of the modern state, such as the hacienda. This article examines a set of modern khipus from the Island of the Sun in Bolivia. These khipus, which contain dried potatoes and beans, are the first ever known to include agricultural produce. Our analysis demonstrates how the circulation of khipu styles within the Island of the Sun was linked to hacienda production, underscoring the intimate relationship between khipus and hacienda culture. Modern herding and crop khipus did not arise out of a generalized Andean consciousness but were products of specific historical and economic circumstances.
MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6
Authors: Yang Jie , Zhou Yunping , Liang Xiaojun , Jing Bingfei , Zhao Zandong 
Published: July 2021

Aims Osteoarthritis (OA) is characterized by persistent destruction of articular cartilage. It has been found that microRNAs (miRNAs) are closely related to the occurrence and development of OA. The purpose of the present study was to investigate the mechanism of miR-486 in the development and progression of OA. Methods The expression levels of miR-486 in cartilage were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The expression of collagen, type II, alpha 1 (COL2A1), aggrecan (ACAN), matrix metalloproteinase (MMP)-13, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4) in SW1353 cells at both messenger RNA (mRNA) and protein levels was determined by qRT-PCR, western blot, and enzyme-linked immunosorbent assay (ELISA). Double luciferase reporter gene assay, qRT-PCR, and western blot assay were used to determine whether silencing information regulator 6 (SIRT6) was involved in miR-486 induction of chondrocyte-like cells to a more catabolic phenotype. Results Compared with osteonecrosis, the expression of miR-486 was significantly upregulated in cartilage from subjects with severe OA. In addition, overexpressed miR-486 promoted a catabolic phenotype in SW1353 cells by upregulating the expressions of ADAMTS4 and MMP-13 and down-regulating the expressions of COL2A1 and ACAN. Conversely, inhibition of miR-486 had the opposite effect. Furthermore, overexpression of miR-486 significantly inhibited the expression of SIRT6, confirming that SIRT6 is a direct target of miR-486. Moreover, SW1353 cells were transfected with small interfering RNA (si)-SIRT6 and it was found that SIRT6 was involved in and inhibited miR-486-induced changes to SW1353 gene expression. Conclusion Our results indicate that miR-486 promotes a catabolic phenotype in SW1353 cells in OA by targeting SIRT6. Our findings might provide a potential therapeutic target and theoretical basis for OA. Cite this article: Bone Joint Res 2021;10(7):459–466.