bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroendokrine Neoplasien
Authors: Chouchane Aziz , Bräutigam Konstantin , Perren Aurel 
Published: February 2025

Zusammenfassung
Neuroendokrine Tumoren (NET) sind eine bunte Gruppe von Neoplasien, die von neuroendokrinen Zellen im gesamten Körper ausgehen. Die NET-Diagnose stellt aufgrund ihrer vielfältigen Erscheinungsformen, Morphologie und biologischen Verhaltensweisen eine besondere Herausforderung dar. Dieser Artikel bietet einen Überblick über die wichtigsten für Allgemeinpathologen relevanten diagnostischen Prinzipien, und betont die Bedeutung eines multidisziplinären Ansatzes, der klinische, radiologische, histopathologische und immunhistochemische Daten integriert. Die Etablierung neuer Marker sowie jüngste Fortschritte in der molekularen Pathologie und die Anwendung von Klassifizierungssystemen werden erörtert, wobei deren Einfluss auf die Prognose und therapeutische Strategien hervorgehoben wird.
Fertilization with Humic Acids in Production Changes the Quality of Fresh and Stored Sweet Pepper Fruits (Capsicum annuum L.)
Authors: Zamljen Tilen , Veberič Robert , Slatnar Ana 
Published: February 2025

Abstract
The objective of this study was to assess the impact of humic acid treatment on the physical and biochemical parameters of ‘Cuccino Orange’ pepper fruits before and after storage, which is crucial since the majority of peppers are stored and not sold directly after harvest. The application of humic acid did not result in any discernible changes in fruit length, width, or dry weight. However, it did significantly enhance pericarp thickness post-storage, particularly in the Humistar treatment, which was connected to higher water contents. The control (C) treatment exhibited the highest water loss, with a value of 5.2% after storage. The sugar composition of the samples exhibited alterations, with increased sucrose and decreased glucose observed in the C treatment, accompanied by reductions in total sugar in the biostimulant treatments. Significant decreases were observed in ascorbic and citric acids, while malic and tartaric acids exhibited increased levels in all treatments. Phenolic content analysis revealed that Humistar treatment exhibited increased total phenolics (31.8%) after storage compared to the control, indicating that humic acid may enhance phenolic accumulation. The specific phenolics, such as chlorogenic acid, exhibited variable changes, thereby highlighting the complex metabolic interactions. The results indicate that humic acid treatments can enhance post-harvest quality by improving structural integrity, water retention, and metabolic content, contributing to a longer shelf life and higher nutritional quality. Further research is necessary to elucidate the underlying mechanisms and to extend these findings to other fruit types and storage conditions.
Correlation of a clinical activity index in comparison to frequently measured laboratory values in inflammatory bowel disease
Authors: Rapo Marja , Molander Pauliina , af Björkesten Clas-Göran , Pakarinen Suvi , Arkkila Perttu 
Published: February 2025

Abstract

Purpose
Several laboratory tests are used to monitor disease activity and possible complications in patients with inflammatory bowel disease (IBD). Due to limited resources, it is important to identify patients who benefit the most from tight laboratory testing and follow-up. We sought to assess the correlation between a symptom-based clinical activity index and commonly monitored laboratory tests in a large patient population.

Methods
The Finnish IBD registry records a validated IBD symptom index questionnaire (IBD-SI) that measures disease activity and the influence of IBD on daily life in patients with ulcerative colitis (UC) and Crohn’s disease (CD). The activity index was compared with the commonly measured laboratory values of fecal calprotectin (FC), hemoglobin (Hb), ferritin, and C-reactive protein (CRP).

Results
A total of 5044 IBD patients with 171,967 activity index measurement pairs were included. FC, Hb, and CRP correlated significantly with the activity index in both UC (Spearman’s r 0.383, −0.212, 0.175; p < 0.001) and CD (Spearman’s r 0.156, −0.176, 0.152; p < 0.001). No correlation between the activity index and ferritin (Spearman’s r 0.038 [UC], 0.005 [CD]; p = 0.020, p = 0.825) was found.

Conclusion
The activity index is a useful tool in the assessment of IBD activity. Active or inactive disease can be identified better, which may be beneficial in planning more personalized follow-up strategies. Tight monitoring of disease can be better targeted to the correct patient population, and the onset of disease flare may be caught at an earlier stage.
Limb-specific blood flow regulation during cycling exercise in traumatic single lower limb amputees
Authors: Pedrinolla Anna , Laginestra Fabio Giuseppe , Martignon Camilla , Cavedon Valentina , Fioraso Elisa , Biasiolo Caterina , Milanese Chiara , Schena Federico 
Published: February 2025

Abstract

Purpose
To investigate the limb-specific blood flow regulation during dynamic bilateral cycling exercise in individuals with traumatic single lower-limb amputation compared to a control group.

Methods
Seven individuals with single lower leg amputation (AMP) (37 ± 11 years, 11 ± 8 years since amputation) and 7 age-matched controls (Ctrl) (36 ± 10 years) were tested during three 5 min constant workload exercise at 60W, 100W, and 80% of peak power output (PPO), on a reclined cycling ergometer. In AMP, femoral blood flow (FBF) and leg vascular conductance (LVC) were measured in the amputated leg (AL) and whole leg (WL), while in Ctrl, the same measurements were obtained in the right and left legs. Interlimb balance was measured with a power meter, and bilateral asymmetry index was calculated for FBF and interlimb balance. Oxygen consumption (

$$\dot{V}$$

V
˙

O2), ventilation (

$${\dot{V}}_{E}$$

V
˙

E

), mean arterial pressure (MAP), heart rate (HR), and cardiac output (CO) were also quantified.

Results
AMP exhibited lower FBF in AL compared to WL (60W, − 61%; 100W, -69%; 80% PPO, − 64%; p < 0.001). LVC increased as expected in WL but did not increase significantly throughout workloads in AL. Interlimb balance exhibited a much higher contribution of the WL (60W, 76% of the work; 100W, 68%; 80% PPO,65%) than AL (60W, 26%; 100W, 34%; 80% PPO, 35%). No differences were found in FBF (p = 0.187), LVC (p = 0.871), and interlimb balance (p = 0.829) in CTRLs. No difference between AMP and CTRL in

$$V$$

V

O2 (p = 0.241),

$${\dot{V}}_{E}$$

V
˙

E

(p = 0.124), MAP (p = 0.186), HR (p = 0.360), and CO (p = 0.144) at any workload was detected.

Conclusion
Individuals with amputation present considerable limb-specific blood flow regulation during bilateral cycling exercise. Understanding the mechanisms for this interlimb difference may provide important information to improve rehabilitation and training in this population.
Early Allograft Dysfunction after liver transplantation– definition, incidence and relevance in a single-centre analysis
Authors: Wiemann Bengt A. , Beetz Oliver , Weigle Clara A. , Tessmer Philipp , Störzer Simon , Kleine-Döpke Dennis , Vondran Florian W. R. , Richter Nicolas , Schmelzle Moritz , Oldhafer Felix 
Published: February 2025

Abstract

Purpose
Early Allograft Dysfunction (EAD) is a serious complication following liver transplantation. With more marginal donors and critical recipients, identifying EAD risk factors and their impact on long-term outcomes is crucial.

Methods
We reviewed all liver transplants performed between 2007 and 2017 at our institution, excluding pediatric recipients, combined thoracic transplants, and retransplants in the same hospital stay. EAD was defined as either: (i) AST/ALT > 2000 IU/l in first 7 postoperative days (POD), (ii) Bilirubin ≥ 10 mg/dl on POD 7, (iii) INR ≥ 1.6 on POD 7.

Results
Of the 621 cases analyzed, the EAD rate was 53.6%. Multivariate analysis identified only donor-dependent variables as independent risk factors for the onset of EAD: donor age (p = 0.012), donor serum sodium (p = 0.021), cold ischemic time (p = 0.007) and graft weight (p < 0.001). EAD significantly impaired graft survival (69.2% vs. 86.2% after 1 year; p = 0.005) but did not impact long-term patient survival (76.3% vs. 87.6% after 1 year; p = 0.162). Of the EAD components, elevated INR proved to be the only reliable predictor of patient mortality. Additionally, an AST/ALT concentration of > 4000 IU/l significantly improved the predictive value of the EAD definition for patient survival (p = 0.002).

Conclusions
EAD risk factors are primarily donor-based and significantly impair graft but not patient survival. The high EAD rates and increased use of marginal grafts suggest the need to adjust conventional EAD definitions to optimize graft allocation in the future
Investigation of dysmenorrhea in adolescent girls with familial Mediterranean fever: a comparative study with healthy controls
Authors: Demirkan Fatma Gül , Yetim Şahin Aylin , Çakmak Figen , Akgün Özlem , Guliyeva Vafa , Tuğrul Aksakal Melike Zeynep , Baş Firdevs , Aktay Ayaz Nuray 
Published: February 2025

Abstract
Perimenstrual attacks have been reported in up to 15% of patients with FMF, suggesting that menstruation may be a trigger for FMF attacks. The aim of this study was to investigate menstrual period patterns and dysmenorrhea in adolescents with FMF in comparison to their healthy peers. This cross-sectional case–control study included 73 FMF patients and 70 age- and body mass index-matched controls. A structured questionnaire was designed to assess menstrual history, the frequency and severity of dysmenorrhea, symptoms related to dysmenorrhea, and the clinical features of FMF attacks. Dysmenorrhea was present in 90.4% of patients and 95.7% of controls (p = 0.32). Pain was reported during every cycle or every two cycles by 83.3% of patients versus 65.6% of controls (p = 0.02). Fever (27.4% vs. 10.3%, p = 0.01) was significantly more frequent in patients, while musculoskeletal symptoms (46.6% vs. 66.2%, p = 0.02), fatigue (53.4% vs. 83.8%, p < 0.001), and sleep disturbances (19.2% vs. 50.7%, p < 0.001) were more common in controls. Notably, FMF patients reported heavier bleeding episodes with higher number of sanitary pads used during menstruation (p = 0.001). Menstruation-associated FMF attacks were reported by 37% of patients, with 14.8% experiencing them every cycle. Exon 10 variants were present in 86.3% of cases, with 23.3% being homozygous. The frequency and character of dysmenorrhea did not differ significantly according to genetic profiles. Conclusions: This study is the first to investigate menstrual patterns and dysmenorrhea symptoms in adolescent FMF patients compared to their healthy peers. Dysmenorrhea is prevalent in FMF patients with distinct menstrual characteristics, including more frequent fever and heavier bleeding.

What is Known:
•
Menstruation may trigger Familial Mediterranean Fever (FMF) attacks in a subset of patients, but the relationship between FMF and dysmenorrhea remains unclear.•
Some studies suggest that inflammation associated with FMF could contribute to menstrual pain and abnormalities, but comprehensive data in adolescents are limited.

What is New:
•
This study is the first to compare menstrual patterns and dysmenorrhea characteristics between adolescent FMF patients and healthy controls, highlighting distinct menstrual symptoms in FMF patients.•
FMF patients experience more frequent febrile episodes and heavier menstrual bleeding compared to their healthy peers, but dysmenorrhea characteristics are not influenced by specific MEFV gene mutations.
Mixed reality representation of hazard zones while collaborating with a robot: sense of control over own safety
Authors: San Martin Ane , Kildal Johan , Lazkano Elena 
Published: February 2025

Abstract
Safety is the main concern in human-robot collaboration (HRC) in work environments. Standard safety measures based on reducing robot speed affect productivity of collaboration, and do not inform workers adequately about the state of the robot, leading to stressful situations due to uncertainty. To grant the user control over safety, we investigate using audio, visual and audio-visual mixed reality displays that inform about the boundaries of zones with different levels of hazard. We describe the design of the hazard displays for scenario of collaboration with a real robot. We then report an experimental user study with 24 users, comparing performance and user experience (UX) obtained with the auditory display, the visual display, and the audio-visual display resulting from combining both. Findings suggest that all modalities are suitable for HRC scenarios, warranting similar performance during collaboration. However, distinct qualitative results were observed between displays, indicating differences in the UX obtained.
Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy
Authors: Yoshimura Ryo-ichi , Toda Kazuma , Watanabe Hiroshi , Miura Masahiko , Notake Ryoichi , Murakami Naoya , Igaki Hiroshi , Nakamura Satoshi , Umezawa Rei , Kadoya Noriyuki , Jingu Keiichi , Itami Jun 
Published: February 2025

Abstract

Background
To evaluate the efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for recurrent head and neck cancer (rHNC) after radiotherapy.

Methods
This study was a multicenter prospective clinical trial. Eligibility criteria included all patients with biopsy-proven rHNC and history of radiotherapy. The efficacy of DaRT was evaluated in terms of tumor shrinkage after 10 weeks of DaRT seed implantation. To assess safety of DaRT, radioactivity levels in blood and urine were measured, and incidence and grade of adverse events (AEs) were evaluated.

Results
Between 2019 and 2021, DaRT was performed in 11 patients and completed in 10 patients with 11 tumors. The tumor sites included the tongue (n = 3), buccal mucosa (2), lips (2), floor of the mouth (1), soft palate (1), nose (1), and subcutaneous layer (1). Nine tumors were confirmed to be squamous cell carcinoma, and the remaining two tumors were basal cell carcinoma and neuroblastoma. Complete response (CR) and partial response (PR) were observed in three and six patients, respectively. The response rate was 81.8%. The maximum average radioactivity levels in blood and urine were 42.5 Bq/cm3 and 8.4 Bq/cm3, respectively, on the second day after implantation. Forty AEs were observed in all 11 patients, including 22 Grade 1 AEs, 16 Grade 2, and 2 Grade 3 (hypertension and seed remnants).

Conclusion
The initial response of rHNC after radiotherapy to DaRT was favorable, and the incidence and grade of AEs were acceptable, as compared to existing therapies.
Atmospheric Dispersion Downstream a Two-Dimensional Obstacle: Experimental Evaluation of Turbulence Closure Models
Authors: Salizzoni Pietro , Fellini Sofia , Gamel Hervé , Marro Massimo , Soulhac Lionel 
Published: February 2025

Abstract
This study investigates the turbulent dispersion of pollutants in the wake of a two-dimensional square obstacle. Utilizing Laser Doppler Anemometry and Particle Image Velocimetry, we characterized the flow dynamics, identifying a recirculation zone downstream of the obstacle, marked by high shear and increased turbulent viscosity, and playing a crucial role in turbulent momentum exchange. We evaluated the turbulence kinetic energy budget, estimating its dissipation rate, and found traditional isotropy and Taylor hypothesis methods inadequate within the wake region. Furthermore, we explored pollutant dispersion from a linear source located downstream the obstacle. Analysis of mean concentration and variance revealed that the log-normal distribution is most effective for modelling concentrations within the recirculating region, while the Gamma distribution suits areas outside it. Testing various closure models for turbulent mass fluxes highlighted the limitations of the Simplified Gradient Diffusion Hypothesis model, favouring more complex closure models for longitudinal trends, though these still faced challenges with intensity estimation. The Simplified Gradient Diffusion Hypothesis model proved robust for vertical mass fluxes, with satisfactory results in turbulent diffusivity and turbulent Schmidt number calculations. The experimental results serve as a benchmark for validating numerical simulations and assessing the accuracy of closure models typically employed in pollutant dispersion modelling.
Lack of induced chemical changes in leaves of susceptible alternate hosts of Cronartium spp. after inoculation by Cronartium pini and C. ribicola
Authors: Piispanen Juha , Bergmann Ulrich , Karhu Jouni , Kauppila Tuomas , Witzell Johanna , Kaitera Juha 
Published: February 2025

Abstract
Phenolic compounds, known for their antioxidant and antifungal properties may be connected to infection processes of Cronartium rusts in alternate host plants. We studied changes in leaf chemistry after Cronartium inoculation on susceptible alternate hosts of C. pini and C. ribicola. Impatiens balsamina and Paeonia lactiflora were inoculated with C. pini, and R. nigrum with C. ribicola in the greenhouse. Leaves of the inoculated plants were harvested 3 and 6 days after inoculation for chemical analysis, which was done using LC–MS (liquid chromatography mass spectrometry). Species-specific differences were found in dominant phenolics ferulic acid, hyperoside, quercitrin, and rutin. Rust inoculation produced limited changes in phenolic concentrations, with significant increases only in p-coumaric acid in I. balsamina and rutin in R. nigrum. Significant post-inoculation decrease was found in several cases. While phenolic fluctuations varied by species and incubation time, there was no significant interaction between inoculation and incubation time, suggesting the absence of induced phenolic accumulation during early infection stages. The results support the hypothesis that susceptible alternate hosts exhibit weak, delayed phenolic defenses, possibly due to rust virulence factors suppressing these responses. Indirectly, they provide support for the defensive role of phenolics in resistant congeneric hosts, emphasizing also the importance of further molecular studies to explore plant defense mechanisms against rust pathogens.
VIRL: Volume-Informed Representation Learning towards few-shot manufacturability estimation
Authors: Chen Yu-hsuan , Cagan Jonathan , Kara Levent Burak 
Published: February 2025

Abstract
Designing for manufacturing poses significant challenges in part due to the computation bottleneck of Computer-Aided Manufacturing (CAM) simulations. Although deep learning as an alternative offers fast inference, its performance is dependently bounded by the need for abundant training data. Representation learning, particularly through pre-training, offers promise for few-shot learning, aiding in manufacturability tasks where data can be limited. This work introduces VIRL, a Volume-Informed Representation Learning approach to pre-train a 3D geometric encoder. The pretrained model is evaluated across four manufacturability indicators obtained from CAM simulations: subtractive machining (SM) time, additive manufacturing (AM) time, residual von Mises stress, and blade collisions during Laser Power Bed Fusion process. Across all case studies, the model pre-trained by VIRL shows substantial enhancements in generalizability, as measured by R2 regression results, with improved performance on limited data and superior predictive accuracy with larger datasets. Regarding deployment strategy, case-specific phenomenon exists where finetuning VIRL-pretrained models adversely affects AM tasks with limited data but benefits SM time prediction. Moreover, the efficacy of Low-rank adaptation (LoRA), which balances between probing and finetuning, is explored. LoRA shows stable performance akin to probing with limited data, while achieving a higher upper bound than probing as data size increases, without the computational costs of finetuning. Furthermore, static normalization of manufacturing indicators consistently performs well across tasks, while dynamic normalization enhances performance when a reliable task dependent input is available.
Time-Spatial Job Crafting and Other Self-Regulation Strategies in Hybrid Work: The Impact of a Self-Training Intervention
Authors: Demerouti Evangelia 
Published: February 2025

Abstract
Hybrid work presents a challenge to employees’ self-regulation skills, requiring them to effectively manage their working time and location while balancing energy between professional and personal activities. The present study introduces a brief, multi-component, self-training intervention for hybrid workers based on solid theory for the choice of trained behaviors and for achieving change and examines whether the trained self-regulation strategies, i.e., time-spatial crafting, work-home domain management, and psychological energy preservation explain improvement on two distal outcomes, namely work engagement and goal attainment. Using a pretest–posttest intervention with a control group (intervention group: N = 39, control group N = 46) and cluster randomization, the training was executed over six consecutive workdays. The self-training included information about self-regulation strategies, reflection exercises, and five daily assignments. Results of multilevel analyses showed that the training effectively increased work-home facilitation and relaxation, which consequently explained increases in goal attainment and, in the case of work-home facilitation, work engagement. Moreover, univariate tests indicated the effectiveness of the training to stimulate time-spatial crafting. The results imply that self-regulating strategies are essential to improve valuable outcomes during hybrid work and can be trained.
Research Assessment Reform as Collective Action Problem: Contested Framings of Research System Transformation
Authors: Rushforth Alexander 
Published: February 2025

Abstract
The rise of managerial logics in research policy and universities in many countries over the past decades, has met with concerns and criticisms about dysfunctional effects of research evaluation and indicator regimes. Recently, concerted trans-national and national reform efforts have emerged seeking collective action to redress this complex, multi-level issue. For some actors in science systems, however, research assessment reform threatens the common good. In this study, I describe and theorize the contours of public debates in the Netherlands, over its national initiative for research assessment reform, Recognition and Rewards. Formally launched in 2019 to coordinate system-wide changes in assessment practices across the Dutch science system, the initiative has so far proved effective in uniting support from multiple influential national stakeholders. Simultaneously, though, it has provoked criticisms and animated debates, with concerns raised over the Netherlands ‘going it alone’ in pursuing reforms. This study makes two original contributions. The first is conceptual: drawing on a collective action frames perspective, I analyze a large corpus of publicly available documents and statements and provide a framework for navigating how the case for collective action on assessment reform is constructed and contested. The second contribution is to call for expanding the agenda of science studies, where existing literature remains centered on critiquing performance indicators and the excellence regime. I argue a new research focus is urgently needed, focusing on the emerging realities, value conflicts, and ambiguities catalyzed by research assessment reform movements.