bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Risk Associated With Ibrutinib Use in Chronic Lymphocytic Leukemia: A Population-Based Cohort Study
Authors: Abdel-Qadir Husam , Sabrie Nasruddin , Leong Darryl , Pang Andrea , Austin Peter C. , Prica Anca , Nanthakumar Kumaraswamy , Calvillo-Argüelles Oscar , Lee Douglas S. , Thavendiranathan Paaladinesh 
Published: August 2021

PURPOSE Ibrutinib reduces mortality in chronic lymphocytic leukemia (CLL). It increases the risk of atrial fibrillation (AF) and bleeding and there are concerns about heart failure (HF) and central nervous system ischemic events. The magnitude of these risks remains poorly quantified. METHODS Using linked administrative databases, we conducted a population-based cohort study of Ontario patients who were treated for CLL diagnosed between 2007 and 2019. We matched ibrutinib-treated patients with controls treated with chemotherapy but unexposed to ibrutinib on prior AF, age ≥ 66 years, anticoagulant exposure, and propensity for receiving ibrutinib. Study outcomes were AF-related health care contact, hospital-diagnosed bleeding, new diagnoses of HF, and hospitalizations for stroke and acute myocardial infarction (AMI). The cumulative incidence function was used to estimate absolute risks. We used cause-specific regression to study the association of ibrutinib with bleeding rates, while adjusting for anticoagulation as a time-varying covariate. RESULTS We matched 778 pairs of ibrutinib-treated and unexposed patients with CLL (N = 1,556). The 3-year incidence of AF-related health care contact was 22.7% (95% CI, 19.0 to 26.6) in ibrutinib-treated patients and 11.7% (95% CI, 9.0 to 14.8) in controls. The 3-year risk of hospital-diagnosed bleeding was 8.8% (95% CI, 6.5 to 11.7) in ibrutinib-treated patients and 3.1% (95% CI, 1.9 to 4.6) in controls. Ibrutinib-treated patients were more likely to start anticoagulation after the index date. After adjusting for anticoagulation as a time-varying covariate, ibrutinib remained positively associated with bleeding (HR, 2.58; 95% CI, 1.76 to 3.78). The 3-year risk of HF was 7.7% (95% CI, 5.4 to 10.6%) in ibrutinib-treated patients and 3.6% (95% CI, 2.2 to 5.4) in controls. There was no significant difference in the risk of ischemic stroke or AMI. CONCLUSION Ibrutinib is associated with higher risk of AF, bleeding, and HF, but not AMI or stroke.
Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia
Authors: Roddie Claire , Dias Juliana , O'Reilly Maeve A. , Abbasian Mahnaz , Cadinanos-Garai Amaia , Vispute Ketki , Bosshard-Carter Leticia , Mitsikakou Marina , Mehra Vedika , Roddy Harriet , Hartley John A. , Spanswick Victoria , Lowe Helen , Popova Bilyana , Clifton-Hadley Laura , Wheeler Graham , Olejnik Joanna , Bloor Adrian , Irvine David , Wood Leigh , Marzolini Maria A. V. , Domning Sabine , Farzaneh Farzin , Lowdell Mark W. , Linch David C. , Pule Martin A. , Peggs Karl S. 
Published: August 2021

PURPOSE Prognosis for adult B-cell acute lymphoblastic leukemia (B-ALL) is poor, and there are currently no licensed CD19 chimeric antigen receptor (CAR) therapeutics. We developed a novel second-generation CD19-CAR (CAT19-41BB-Z) with a fast off rate, designed for more physiologic T-cell activation to reduce toxicity and improve engraftment. We describe the multicenter phase I ALLCAR19 ( NCT02935257 ) study of autologous CAT19-41BB-Z CAR T cells (AUTO1) in relapsed or refractory (r/r) adult B-ALL. METHODS Patients age ≥ 16 years with r/r B-ALL were eligible. Primary outcomes were toxicity and manufacturing feasibility. Secondary outcomes were depth of response at 1 and 3 months, persistence of CAR-T, incidence and duration of hypogammaglobulinemia and B-cell aplasia, and event-free survival and overall survival at 1 and 2 years. RESULTS Twenty-five patients were leukapheresed, 24 products were manufactured, and 20 patients were infused with AUTO1. The median age was 41.5 years; 25% had prior blinatumomab, 50% prior inotuzumab ozogamicin, and 65% prior allogeneic stem-cell transplantation. At the time of preconditioning, 45% had ≥ 50% bone marrow blasts. No patients experienced ≥ grade 3 cytokine release syndrome; 3 of 20 (15%) experienced grade 3 neurotoxicity that resolved to ≤ grade 1 within 72 hours with steroids. Seventeen of 20 (85%) achieved minimal residual disease–negative complete response at month 1, and 3 of 17 underwent allogeneic stem-cell transplantation while in remission. The event-free survival at 6 and 12 months was 68.3% (42.4%-84.4%) and 48.3% (23.1%-69.7%), respectively. High-level expansion (Cmax 127,152 copies/µg genomic DNA) and durable CAR-T persistence were observed with B-cell aplasia ongoing in 15 of 20 patients at last follow-up. CONCLUSION AUTO1 demonstrates a tolerable safety profile, high remission rates, and excellent persistence in r/r adult B-ALL. Preliminary data support further development of AUTO1 as a stand-alone treatment for r/r adult B-ALL.
TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology and Disease
Authors: Nelson Adam T , Wang Yu , Nelson Erik R 
Published: August 2021

Abstract
TLX (NR2E1), an orphan member of the nuclear receptor superfamily, is a transcription factor that has been described to be generally repressive in nature. It has been implicated in several aspects of physiology and disease. TLX is best known for its ability to regulate the proliferation of neural stem cells and retinal progenitor cells. Dysregulation, overexpression, or loss of TLX expression has been characterized in numerous studies focused on a diverse range of pathological conditions, including abnormal brain development, psychiatric disorders, retinopathies, metabolic disease, and malignant neoplasm. Despite the lack of an identified endogenous ligand, several studies have described putative synthetic and natural TLX ligands, suggesting that this receptor may serve as a therapeutic target. Therefore, this article aims to briefly review what is known about TLX structure and function in normal physiology, and provide an overview of TLX in regard to pathological conditions. Particular emphasis is placed on TLX and cancer, and the potential utility of this receptor as a therapeutic target.
Reproducibility and diagnostic value of a new wedge-guided bitewing image receptor-holding device
Authors: Cascante-Sequeira Deivi , Gaêta-Araujo Hugo , Moura Brasil Danieli , Queiroz Freitas Deborah , Haiter-Neto Francisco 
Published: August 2021

Objective To assess the reproducibility of a wedge-guided bitewing image receptor-holding device (IRHD-WG) compared to a commercially available bitewing image receptor-holding device (IRHD-XCP). Methods and materials Ten operators randomly acquired bitewing radiographs of four posterior regions (Premolar, Molar 1, Molar 2, Molar 3) distributed in two dry bone skulls and mandibles using 2 IRHDs (IRHD-WG and IRHD-XCP). The radiographs corresponding to the same region and IRHD but acquired by different operators were paired for reproducibility comparison. A total of 360 pairs of radiographs were randomized for analysis. Objective analysis consisted of extracting the pixel values from each radiograph and comparing the values between each pair by intraclass correlation coefficient. For subjective analysis, the IRHDs images were digitally removed. Five oral radiologists blinded for the study conditions classified the radiograph pairs according to their similarity and diagnostic value. The answers’ relative frequencies were compared by the chi-square test (α = 0.05). Results The IRHD-WG presented a higher reproducibility (Mean = 0.850; SD = 0.144) than the IRHD-XCP (Mean = 0.615; SD = 0.287) in the objective analysis. Radiographs acquired with the IRHD-WG were more similar than those acquired with the IRHD-XCP (p < 0.001). The diagnostic value of bitewing radiographs acquired with the IRHD-WG was considered superior to those acquired with the IRHD-XCP (p < 0.001). Conclusion For the objective and subjective analyses of reproducibility, the IRHD-WG performed better than the commercial IRHD-XCP.
Towards the Peculiarities of Jean-Luc Melenchon’s Idiolecte
Authors: Loginova Polina 
Published: August 2021

The paper presents the analysis of the peculiarities of the verbal behaviour of the French politician Jean-Luc Mélenchon. On the examples obtained from his interviews and videos, the author demonstrates that by means of such figures of speech as metaphors and phraseological units, the French politician was able to materialize his persuasive strategies by manipulating people’s minds. It is emphasized that metaphoric expressions used within the idiolect of Jean-Luc Mélenchon were able to form positive or negative image and perception of the politician, therefore the role of these figures of speech cannot be underestimated.
It is also observed that the study of metaphors is considered to be extremely important within the learning process at the University, especially when teaching the language of French political communication to students in Political Science, International Journalism and Diplomacy.
Effects of a Self-Advocacy Intervention on Abilities of Black College Students With Intellectual and Developmental Disabilities to Request Academic Accommodations
Authors: Brendli Katherine R. , Scott LaRon A. , Xu Yaoying , Thoma Colleen , Holzberg Debra 
Published: August 2021

Abstract
Several barriers exist that inhibit the success of students with disabilities in postsecondary education environments, one of which is the lack of self-advocacy skills to effectively request academic modifications and ask for other supports when needed. In this study, we used a single-subject multiple-probe across participants design to examine the effects of a self-advocacy intervention on the abilities of college students with intellectual and developmental disabilities (IDD) to request their academic accommodations. We primarily focused the intervention on Black youth with IDD attending an inclusive higher education program. Results indicate moderate to strong evidence of a functional relation between the intervention and the students' abilities to request academic accommodations. Implications for future research, policy, and practice are discussed.
Design and Realization of Band Pass Filter in K-Band Frequency for Short Range Radar Application
Authors: Setiawan Arie , Taufiqqurrachman Taufiqqurrachman , Firdaus Adam Kusumah , Darwis Fajri , Rizal Aminuddin , Desvasari Winy , Arisesa Hana , Sulistyaningsih Sulistyaningsih , Putranto Prasetyo , Armi Nasrullah , Arseno Dharu 
Published: August 2021

Short range radar (SRR) uses the K-band frequency range in its application. The radar requires high-resolution, so the applied frequency is 1 GHz wide. The filter is one of the devices used to ensure only a predetermined frequency is received by the radar system. This device must have a wide operating bandwidth to meet the specification of the radar. In this paper, a band pass filter (BPF) is proposed. It is designed and fabricated on RO4003C substrate using the substrate integrated waveguide (SIW) technique, results in a wide bandwidth at the K-band frequency that centered at 24 GHz. Besides the bandwidth analysis, the analysis of the insertion loss, the return loss, and the dimension are also reported. The simulated results of the bandpass filter are: VSWR of 1.0308, a return loss of -36.9344 dB, and an insertion loss of -0.6695 dB. The measurement results show that the design obtains a VSWR of 2.067, a return loss of -8.136 dB, and an insertion loss of -4.316 dB. While, it is obtained that the bandwidth is reduced by about 50% compared with the simulation. The result differences between simulation and measurement are mainly due to the imperfect fabrication process.
Performance Evaluation of DSRC-Zigbee Heterogeneous Network for Intelligent Transportation System
Authors: Hariyadi Randi Eriko , Endroyono E. , Affandi Achmad 
Published: August 2021

Transportation is one of the primary needs of human beings that cannot be avoided, with the increasing vehicle can lead to a congested road situation which can lead to less safe road safety. An Intelligent Transportation System (ITS) can be used to increase road safety. This system uses a Dedicated Short-Range Communication (DSRC) protocol for network access due to its low latency transmission time. Unfortunately, there is research shows that DSRC has a performance issue in a dense area or increased network load. This problem is mostly solved with a heterogeneous network DSRC-LTE but utilizes mobile phone networks that dynamically change can lead to inconsistent and unpredictable network performance. There is some research about ZigBee for ITS shows that it is decent enough for non-critical applications. Thus, the authors try to utilize Zigbee to create the DSRC-Zigbee heterogeneous network so that the network is independent for the ITS application. The proposed heterogeneous network is a fixed model due to its simple architecture. OMNeT++ and Simulation of Urban Mobility (SUMO) are used to evaluate the performance of the network in an urban area with various scenarios. The simulation result shows that the proposed heterogeneous network is capable to improve the messages dissemination rate by 15.78% and 1.22% in a certain scenario compared to the homogeneous network DSRC only.
“Pois não tem de quem se valer senão de Vossa Majestade que é mãe das órfãs pobres honradas”
Authors: Braga Paulo Drumond 
Published: August 2021

Neste artigo, estudam-se alguns pedidos de esmola dirigidos em 1789 a D. Maria I, rainha de Portugal. Entre as diversas formas que os pobres tinham, na época, de obter auxílio, encontrava-se a solicitação, por escrito, de uma esmola, quer a Misericórdias, quer a outras confrarias, quer a particulares poderosos, nomeadamente membros da família real. Esses pedidos eram frequentemente atendidos positivamente, uma vez que a ajuda aos desvalidos da fortuna integrava o arquétipo do bom cristão da época e, por outro lado, visava, por parte de quem esmolava, alcançar a vida eterna, surgindo a caridade e a assistência como complementos de outras formas de intercessão salvífica, nomeadamente a celebração de missas e a instituição de capelas.
PALAVRAS-CHAVE: Portugal. Pobreza. Petições de Pobres. Esmolas.
Em torno da (des)igualdade dos sexos e da educação das mulheres
Authors: Alves-Jesus Susana Mourato 
Published: August 2021

No presente artigo caracterizamos o modo como era apreendido o universo feminino no séc. XVIII em Portugal e observamos de que forma se assistiu paulatinamente, neste contexto, a uma consciencialização para os direitos das mulheres, por via da afirmação da igualdade entre os sexos e de uma educação alargada a todos.
PALAVRAS-CHAVE: Mulheres. Direitos Humanos. Portugal. Igualdade. Educação.
História e Memória
Authors: Abreu Irene Silva de , Gonçalves Josiane Peres 
Published: August 2021

O objetivo principal deste trabalho é o de investigar as lutas e as conquistas da mulher por direitos importantes, como aqueles que lhe conferiram espaço e certo reconhecimento, principalmente nos campos social, político e cultural. Para tal, considerou-se relevante abordar a gênese da desigualdade entre homens e mulheres, bem como a centralidade dos movimentos feministas na trajetória de luta da mulher em busca de seus direitos. A pesquisa em questão se utiliza do método materialista histórico e é de natureza predominantemente bibliográfica. Evidenciou-se que, durante o desenrolar da história, os movimentos sob a liderança feminina proporcionaram conquistas usufruídas pela mulher contemporânea. Dessa maneira, ao passo que se afirmam como cidadãs e sujeitos de direito, as mulheres modernas podem lutar por novos objetivos. Destaca-se, pois, que tais lutas se travam, inclusive e especialmente, em Goiás.
PALAVRAS-CHAVE: Movimentos Feministas. Lutas e Conquistas. Direitos da Mulher. Cidadania.
A família feminina de D. Mariana Vitória de Bourbon: mulheres e linhagens ao serviço da rainha (1750 − 1781)
Authors: Catarino Adriana Rodrigues 
Published: August 2021

O presente artigo pretende estudar a evolução e composição do núcleo familiar feminino de D. Mariana Vitória de Bourbon entre 1750 e 1781. Neste sentido, privilegia-se a abordagem do perfil sociológico e das formas de retribuição das camareiras-mores, donas de honor, damas e demais senhoras que serviram a soberana.
PALAVRAS-CHAVE: D. Mariana Vitória de Bourbon. Casa das Rainhas.Nobreza. Corte. Rainhas.
As mulheres e a doença
Authors: Esteves Alexandra 
Published: August 2021

Em Portugal, não abundam os trabalhos, no âmbito da história das mulheres, sobre as doenças específicas do sexo feminino, embora o parto e os riscos que lhe são inerentes estejam muito presentes na literatura médica, designadamente nos séculos XVIII e XIX. Sem haver a pretensão de colmatar essa lacuna, pretendemos, com o presente artigo, dar a conhecer, entre outros aspetos, as enfermidades que mais afetavam a mulher em diferentes contextos, o modo como a sociedade e a medicina encaravam a condição feminina e era justificada a pretensa inferioridade da mulher face ao sexo masculino, que terapias eram usadas para combater os males de que padeciam, que produtos e processos usados para a prática do aborto. Para a consecução dos objetivos estabelecidos, recorremos, essencialmente, à literatura médica e a estudos que versam sobre a temática que constitui objeto do nosso trabalho.
PALAVRAS-CHAVE: Mulher. Doença. Literatura Médica. Terapias.
A Nupcialidade no Reinado de D. José I (1750-1777)
Authors: Barata Ana Margarida Fernandes 
Published: August 2021

A demografia portuguesa e europeia da época moderna encontra-se desenvolvida ao ponto de podermos estabelecer padrões e encontrar semelhanças e particularidades em várias regiões. Este artigo tem como objetivo perceber se a paróquia de Serpins se insere nesses padrões, nomeadamente os ritmos de nupcialidade, durante o reinado de D. José I (1750-1777).
PALAVRAS-CHAVE: Demografia. Nupcialidade. Freguesia de Serpins
Madalena pregadora
Authors: Duran Maria Renata da Cruz , Molina Ana Heloisa 
Published: August 2021

A pregação sagrada cristã foi um dos acentos do movimento confessional dos séculos XVII e XVIII na Europa, todavia, a licença para o uso da palavra era resguardada aos homens. Não obstante, algumas religiosas, além de escreverem regulamentos institucionais, cartas e memórias, dedicaram-se à elaboração de textos tanto acerca de sermões quanto em formato sermonístico. Paralelamente, a bibliografia especializada, embora não encontre uma prova cabal da pregação feminina, indica sua possibilidade de existência. Na aridez dos estudos, representações e fontes sobre uma eventual pregação feminina, começamos por identificar as imagens barrocas das religiosas das letras querendo, com isso, materializar as metáforas de uma intelligentsia feminina, representada nos sermões pregados por homens. Depois, garimpamos as relíquias do uso da palavra pelas vozes femininas portuguesas, procurando demonstrar sua literacia no universo parenético, assim como a convicção de que essa lacuna não implica numa inexistência, mas antes num silenciamento.
PALAVRAS-CHAVE: Barroco Português. Mulheres Letradas. Sermonística Lusófona.
Retour des expériences individuelles de stage pour un apprentissage collaboratif
Authors: Grandjean Jacques 
Published: August 2021

S’appuyant sur des théories du groupe et des apports théorico-pratiques sur la méthode de conduite de groupe, l’auteur montre en quoi l’expérience du groupe et du travail de groupe, régulée par un conducteur de groupe expérimenté, contribue à l’apprentissage de la complexité et de co-apprentissage permettant l’acquisition de compétences psychosociales et d’aptitudes au travail collaboratif.
Il s’appuie sur l’analyse d’un séminaire de retour d’expérience du stage d’ingénieur pour montrer qu’en mettant le groupe, lieu de confrontation des différences, au centre du dispositif, il est possible de développer les capacités des étudiants au co-apprentissage et d’accompagner l’individualisation de leurs dynamiques professionnelles.
Poincaré Inequality for a Mesh-Dependent 2-Norm on Piecewise Linear Surfaces with Boundary
Authors: Walker Shawn W. 
Published: August 2021

AbstractWe establish several useful estimates for a non-conforming 2-norm posed on piecewise linear surface triangulations with boundary, with the main result being a Poincaré inequality. We also obtain equivalence of the non-conforming 2-norm posed on the true surface with the norm posed on a piecewise linear approximation. Moreover, we allow for free boundary conditions. The true surface is assumed to beC2,1C^{2,1}when free conditions are present; otherwise,C2C^{2}is sufficient. The framework uses tools from differential geometry and the closest point map (see [G. Dziuk, Finite elements for the Beltrami operator on arbitrary surfaces,Partial Differential Equations and Calculus of Variations, Lecture Notes in Math. 1357, Springer, Berlin (1988), 142–155]) for approximating the full surface Hessian operator. We also present a novel way of applying the closest point map when dealing with surfaces with boundary. Connections with surface finite element methods for fourth-order problems are also noted.
From Dream to Reality: The Ambivalent Role of Nascent Entrepreneurs’ Motivation in the Intention-Action Gap
Authors: Blank Tali Hadasa , Gabay-Mariani Laëtitia 
Published: August 2021

Abstract
This paper addresses nascent entrepreneurs’ intention-action gap by examining the predictive and the moderating role of different types of motivations. We draw on the theory of planned behavior and on action theory to explain the entrepreneurial action of 205 student nascent entrepreneurs operating in academic incubators within the French higher education system. Our results demonstrate an indirect influence of extrinsic and intrinsic motivation on entrepreneurial action. When referring to motivation as moderating the relationship between intention and action, we show that mid-levels of extrinsic and intrinsic motivation reinforce the positive association between nascent entrepreneurs’ intentions and actions. Our study demonstrates the importance of distinguishing between motivational and volitional phases of the entrepreneurial process, and provides new insights for academic institutions seeking to incubate businesses created by student nascent entrepreneurs.
Mariusz Soltanifar, Mathew Hughes, Lutz Gocke – Digital Entrepreneurship, Impact on Business and Society (2021, Springer International Publishing)
Authors: Ranković Marko , Ilić Milena P. 
Published: August 2021

Abstract
The book by Mariusz Soltanifar, Mathew Hughes, and Lutz Göcke entitled “Digital Entrepreneurship Impact on Business and Society” (Soltanifar, M., M. Hughes, and L. Göcke. 2021. Digital Entrepreneurship Impact on Business and Society. Charm: Springer International Publishing; Springer) published by Springer International Publishing demonstrates the global challenges that companies and economies face related to digital entrepreneurship. The book emphasizes the impact that digital entrepreneurial activities have on business and society in a way that shapes the world business environment in the present time, and will continue to the same in the future. The book provides the reader with an overview of the processes, means, and challenges that are transforming the business world, giving the possible opportunities to companies and citizens, but also threats as well that also shape their everyday life and society as a whole.