bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry 4.0 and green supply chain practices: an empirical study
Authors: Umar Muhammad , Khan Syed Abdul Rehman , Yusoff Yusliza Mohd , Ali Shahzad , Yu Zhang 
Published: June 2021

PurposeThe purpose of this study is to examine the impact of Industry 4.0 on economic and environmental performance through the mediation of green supply chain management (GSCM) practices in the emerging economic context, like Pakistan.Design/methodology/approachThis cross-sectional study investigates Industry 4.0 effects on economic and environmental performance through GSCM practices in an emerging economy. For the testing of hypotheses, Smart-PLS is employed. In total, 284 valid responses were analyzed in this study.FindingsThe outcomes indicate that GSCM practices mediate the effect of Industry 4.0 on both economic and environmental performance. Also, the results indicate that GSCM practices are positively affected by Industry 4.0.Research limitations/implicationsThe scope of this study is limited to manufacturing firms in Pakistan. Future studies may explore other variables that could expedite the adoption of GSCM as the concept of GSCM is still in its infancy. Future studies can conceptualize GSCM through resource based theory as mainstream SCM research has largely ignored the synergistic view of resource based approach in conceptualizing green supply chain models. Implications include policy making that emphasis on enhancing environmental knowledge training.Originality/valueAccording to the best knowledge of the researcher, no study has been conducted regarding the effect of Industry 4.0 on economic and environmental performance through the mediation of GSCM practices in the emerging economy, like Pakistan.
The impact of COVID-19 closures on the Megalithic Temples of Malta UNESCO world heritage site
Authors: Caruana Josef , Debono Elaine , Stroud Katya , Zammit MariaElena 
Published: June 2021

PurposeThis study will determine the impact COVID-19 closures had on the Megalithic Temples of Malta. The physical, economic, social and conservation impacts will be discussed.Design/methodology/approachThis study relies mainly on field observations of the effects managerial and state decisions had on the sites. A timeline from February to July 2020 will outline all major events and changes caused by the COVID-19 pandemic happening in Malta and specifically within Heritage Malta sites.FindingsThe pandemic impacted the sites under study economically, and socially, whilst the impact on the sites attributed to visitors and other agents of deterioration were variable. These findings affected the way sites reopened to the public with restrictions and additional safety measures.Originality/valueThis article highlights the effect the pandemic had on archaeological sites in Central Mediterranean islands which are heavily reliant on tourism. It also highlights the important role such open-air sites have within the local community.
Íhé Ńkètá and Òkè: concepts and practice of indigenous cultural heritage management in the Igbo cultural area of south-eastern Nigeria
Authors: Onyemechalu Stanley Jachike , Ugwuanyi J. Kelechi 
Published: June 2021

PurposeThis study explored an alternative understanding of heritage through the lens of the Igbo cultural group in Nigeria. It used the Igbo concept of “Ihe Nketa” or “Oke” to examine the complex relationship between indigeneity, attachment and sustainability in the context of heritage management and conservation.Design/methodology/approachA qualitative approach was used, and ethnographic methods of data collection that include interviews and focus-group discussions (FGD) applied. The interview participants included village chiefs and the elderly (men and women), and the FGD comprised village elders (men and women) and youths. The interview guide contained demographic questions to determine age and occupation, followed by interactive open-ended questions stemming from the study's objectives. The interviews were conducted in the language most preferred by the respondents such as the Igbo language, Nigerian Pidgin English and the English language. The evidence generated was thematically analysed in a descriptive and interpretive manner.FindingsThe study found that while the Igbo understanding of heritage have related meaning with the definitions offered by the United Nations, their approach to heritage conservation takes a different turn through the concepts of “Ihe Nketa” or “Oke,” which recognises the ephemerality of tangible heritage resources with particular focus on the preservation of intangible heritage–knowledge over objects. The Igbo approach describes the framework for the acquisition, use and transfer of heritage resources in the Igbo society.Originality/valueThis study contributes to the understanding of the concept of heritage through the lens of the Igbo of Nigeria. Against the centralised national management approach to heritage, this paper argues that achieving sustainable heritage management in a multi-ethnic country like Nigeria requires the recognition of the principles that conserve(d) and manage(d) heritage among the indigenous/local peoples.
How long are newcomers new in different occupations?
Authors: Capitano Johnna , Mishra Vipanchi , Selvarathinam Priyatharsini , Collins Amy , Crossett Andrew 
Published: June 2021

Purpose
This study aims to examine the effects of occupational characteristics on the length of time required to socialize newcomers. The authors examine task mastery, role clarity and social acceptance as indicators of socialization.

Design/methodology/approach
To test the hypotheses, the authors used occupational data from the Bureau of Labor Statistics and survey data of subject matter experts in 35 occupations.

Findings
Findings show that occupational differences account for a significant variance in the time needed to socialize newcomers. Across occupations, it takes longer to achieve task mastery than role clarity or social acceptance. Occupational complexity increases the time it takes for newcomers to attain task mastery, role clarity and social acceptance. Additionally, unstructured work and decision-making freedom increase the time it takes for newcomers to attain role clarity.

Originality/value
This study provides both theoretical and empirical guidance on the duration of the organizational socialization period. The study also provides empirical support for prior propositions that different types of newcomer learning occur at different rates.
Organizational experience of social media: impacts on competitive intelligence
Authors: Carvalho Diogo , Picoto Winnie , Busch Peter 
Published: June 2021

PurposeThe paper aims to clarify the potential impact of data gathered from social media (SM) in the competitive intelligence (CI) process of organizations. As use of SM expands, analysis of this data becomes a critical business need providing essential support for decision makers. This paper seeks to examine how SM be used to enhance CI in an organizational context.Design/methodology/approachThis paper adopted an exploratory mixed-method approach followed by a sequential and equal status design, with qualitative semi-structured interviews, accounting for the qualitative study and serving as precursor to a quantitative structured survey. Interviewees included a university professor and CI consultant, an SM analyst and a subject in a management position – all in the field of CI. A survey was sent to Fortune 1000 companies. Some 227 companies replied.FindingsThe findings were that the majority of respondents produce CI reports at least monthly, and that information transmitted mainly by presentation within organizations. Over 70% of companies outsource CI activities to specialized firms, while 80.9% of organizations felt CI improved their relationship with their customers. Not surprisingly, as the number of people dedicated to CI activities increased, the likelihood of an organization hiring outside companies specializing in CI diminished.Research limitations/implicationsAll organizations sampled were large US companies; thus, small- and medium-sized enterprises were excluded, as were non-US viewpoints. As survey respondents were anonymous, the source of data at the level of the individual is missing. Finally, only three interviewees provided the qualitative data.Practical implicationsThis investigation determined organizations should have an established and well-structured CI department. Furthermore, such a department should have between five and ten employees to maximize the potential. Outsourcing depends on the company’s specific needs. Nevertheless, regardless of whether it outsources CI activities or not, each firm should monitor SM to enhance the CI process.Originality/valueMuch SM-based CI is either non-existent or in “embryotic” stages in most companies, and therefore still a work in progress. Furthermore, as SM is a relatively new phenomenon, studies supporting its implementation are scarce. Companies stand to gain significant improvements to CI if SM is effectively used.
Dietary differences between grasshoppers are associated with life history tradeoffs in an alpine meadow
Authors: Lan Bin , Dong Yuran , Niklas Karl J. , Sun Shucun 
Published: June 2021

AbstractDietary differences are often observed among generalist herbivores co‐occurring in the same community. However, the factors underlying the differences remain poorly understood. In the context of insect herbivores, we hypothesized that interspecific dietary differences are associated with life history traits. Specifically, we hypothesized that the size of wings as well as gender participate in defining dietary preferences, that is, long‐winged species and males will tend to forage on plants with high C/N to maximize dispersal and mating, whereas short‐winged species and females will forage on N‐rich plants to maximize egg production. We tested this hypothesis by examining the diets of the males and females of three long‐winged and two short‐winged grasshopper species in an alpine meadow. The dietary composition and relative abundance of each species were determined using DNA meta‐barcoding. The data showed that the consumed plant species were similar among all of the grasshopper species and between the males and females. However, quantitative differences in the diets were significant between the long‐winged and short‐winged guilds and between the males and females of each species. Consistent with the hypothesis, (1) the long‐winged species fed more on monocots with high C/N, whereas the short‐winged species fed more on legumes with high N contents, (2) for each short‐winged species the males fed more on monocots with high C/N compared to the females, and (3) across all grasshopper species, egg numbers were positively associated with the weighted dietary N. These data indicate that the dietary preferences of these generalist grasshoppers are associated with life history tradeoffs.
Negotiating identities of ‘responsible drinking’: Exploring accounts of alcohol consumption of working mothers in their early parenting period
Authors: Vicario Serena , Peacock Marian , Buykx Penny , Meier Petra Sylvia , Bissell Paul 
Published: June 2021

AbstractMothers’ alcohol consumption has often been portrayed as problematic: firstly, because of the effects of alcohol on the foetus, and secondly, because of the association between motherhood and morality. Refracted through the disciplinary lens of public health, mothers’ alcohol consumption has been the target of numerous messages and discourses designed to monitor and regulate women's bodies and reproductive health. This study explores how mothers negotiated this dilemmatic terrain, drawing on accounts of drinking practices of women in paid work in the early parenting period living in Northern England in 2017–2018. Almost all of the participants reported alcohol abstention during pregnancy and the postpartum period and referred to low‐risk drinking practices. A feature of their accounts was appearing knowledgeable and familiar with public health messages, with participants often deploying ‘othering’, and linguistic expressions seen in public health advice. Here, we conceptualise these as Assumed Shared Alcohol Narratives (ASANs). ASANs, we argue, allowed participants to present themselves as morally legitimate parents and drinkers, with a strong awareness of risk discourses which protected the self from potential attacks of irresponsible behaviour. As such, these narratives can be viewed as neoliberal narratives, contributing to the shaping of highly responsible and self‐regulating subjectivities.
Exploiting within‐breed variability in the autochthonous Reggiana breed identified several candidate genes affecting pigmentation‐related traits, stature and udder defects in cattle
Authors: Bovo S. , Schiavo G. , Kazemi H. , Moscatelli G. , Ribani A. , Ballan M. , Bonacini M. , Prandi M. , Dall’Olio S. , Fontanesi L. 
Published: June 2021

SummaryAutochthonous cattle breeds constitute important reservoirs of genetic diversity. Reggiana is an Italian local cattle breed reared in the north of Italy for the production of a mono‐breed Parmigiano–Reggiano cheese. Reggiana cattle usually have a classical solid red coat colour and pale muzzle. As part of the strategies designed for the sustainable conservation of this genetic resource, we investigated at the genome‐wise level the within‐breed detected variability of three pigmentation‐related traits (intensity of red coat colour, based on three classes – light/diluted, normal and dark; spotted patterns/piebaldism that sometime emerge in the breed; muzzle colour – pink/pale, grey and black), stature, presence/absence and number of supernumerary teats and teat length. A total of 1776 Reggiana cattle (about two‐thirds of the extant breed population) were genotyped with the GeneSeek GGP Bovine 150k SNP array and single‐marker and haplotype‐based GWASs were carried out. The results indicated that two main groups of genetic factors affect the intensity of red coat colour: darkening genes (including EDN3 and a few other genes) and diluting genes (including PMEL and a few other genes). Muzzle colour was mainly determined by MC1R gene markers. Piebaldism was mainly associated with KIT gene markers. Stature was associated with BTA6 markers upstream of the NCAPG–LCORL genes. Teat defects were associated with TBX3/TBX5, MCC and LGR5 genes. Overall, the identified genomic regions not only can be directly used in selection plans in the Reggiana breed, but also contribute to clarifying the genetic mechanisms involved in determining exterior traits in cattle.
Drug induced vitiligo‐like depigmentation from a CDK 4/6 inhibitor
Authors: Chan On B. , Su John C. , Yazdabadi Anousha , Chan Arlene 
Published: June 2021

AbstractRibociclib is an inhibitor of cyclin‐dependent kinases 4 and 6 (CDK 4/6) that is used in combination with an aromatase inhibitor in the first‐line setting for advanced or metastatic hormone receptor positive and human epidermal growth factor receptor 2 (HER2)‐negative breast cancer. We report two cases of drug‐induced vitiligo‐like depigmentation (DI‐VLD) associated with ribociclib. The awareness of this side effect is important given the increasing use of this drug and others with a similar mechanism of action.
Combination chemotherapy with NAB®‐paclitaxel and capecitabine for patients with advanced biliary tract cancer (NAP‐CAPABIL Pilot Study)
Authors: Woodford Rachel , Brungs Daniel , Leighton Carly , Grimison Peter , Sjoquist Katrin M. , Becker Therese , Robinson Samuel , Gebski Val , Wilson Kate , Chantrill Lorraine , Aghmesheh Morteza 
Published: June 2021

AbstractBackground Advanced biliary tract cancer (ABTC) is a highly aggressive malignancy, with a 5‐year overall survival of < 10%. Although preliminary evidence suggests a role of targeted treatments or immunotherapy in a subset of patients, chemotherapy remains the standard second‐line treatment in the majority. We conducted a pilot study of second‐line chemotherapy with capecitabine and nab‐paclitaxel after failure of gemcitabine and platinum.MethodsEligible patients had histologically proven, unresectable biliary tract cancer, which had progressed on a gemcitabine/platinum doublet. In this single‐arm, multicenter trial, all patients received capecitabine (825 mg/m2 bd PO D1‐14 q21d) and nab‐paclitaxel (125 mg/m2 IV D1,8 q21d) until progression or unacceptable toxicity. The primary objective was feasibility of delivering the proposed regimen, with secondary objectives of disease control measures and QOL outcomes.ResultsTen patients were enrolled between 2015 and 2016 from four cancer centers in NSW. Treatment was generally well tolerated with grade III toxicities in five patients (including infection, cholangitis, obstruction, and intestinal perforation) and no grade IV toxicity. Median treatment duration was 4.3 months, with a disease control rate of 80% (8/10), and median progression‐free and overall survival of 5.7 and 12.1 months, respectively. Quality of life data and specimens for translational research have been collected.ConclusionsOur pilot study demonstrates that combination of capecitabine and nab‐paclitaxel is feasible as a second‐line treatment in ABTC. Adequate safety and promising early efficacy signals make further assessment of the combination in a formal phase II or III trial reasonable. Clinical trial information: ACTRN12615000504516.
Separation of the CaV1.2‐CaV1.3 calcium channel duo prevents type 2 allergic airway inflammation
Authors: Giang Nicolas , Mars Marion , Moreau Marc , Mejia Jose E. , Bouchaud Grégory , Magnan Antoine , Michelet Marine , Ronsin Brice , Murphy Geoffrey G. , Striessnig Joerg , Guéry Jean‐Charles , Pelletier Lucette , Savignac Magali 
Published: June 2021

AbstractBackgroundVoltage‐gated calcium (Cav1) channels contribute to T‐lymphocyte activation. Cav1.2 and Cav1.3 channels are expressed in Th2 cells but their respective roles are unknown, which is investigated herein.MethodsWe generated mice deleted for Cav1.2 in T cells or Cav1.3 and analyzed TCR‐driven signaling. In this line, we developed original fast calcium imaging to measure early elementary calcium events (ECE). We also tested the impact of Cav1.2 or Cav1.3 deletion in models of type 2 airway inflammation. Finally, we checked whether the expression of both Cav1.2 and Cav1.3 in T cells from asthmatic children correlates with Th2‐cytokine expression.ResultsWe demonstrated non‐redundant and synergistic functions of Cav1.2 and Cav1.3 in Th2 cells. Indeed, the deficiency of only one channel in Th2 cells triggers TCR‐driven hyporesponsiveness with weakened tyrosine phosphorylation profile, a strong decrease in initial ECE and subsequent reduction in the global calcium response. Moreover, Cav1.3 has a particular role in calcium homeostasis. In accordance with the singular roles of Cav1.2 and Cav1.3 in Th2 cells, deficiency in either one of these channels was sufficient to inhibit cardinal features of type 2 airway inflammation. Furthermore, Cav1.2 and Cav1.3 must be co‐expressed within the same CD4+ T cell to trigger allergic airway inflammation. Accordingly with the concerted roles of Cav1.2 and Cav1.3, the expression of both channels by activated CD4+ T cells from asthmatic children was associated with increased Th2‐cytokine transcription.ConclusionsThus, Cav1.2 and Cav1.3 act as a duo, and targeting only one of these channels would be efficient in allergy treatment.
Vices in autonomous paternalism: The case of advance directives and persons living with dementia1
Authors: Um Sungwoo 
Published: June 2021

AbstractAdvance directives are intended to extend patient autonomy by enabling patients to prospectively direct the care of their future incapacitated selves. There has been much discussion about issues such as whether the future incompetent self is identical to the agent who issues the advance directive or whether advance directives can legitimately secure patient autonomy. However, there is another important question to ask: to what extent and in what conditions is it ethically appropriate for one to limit the liberty or agency of one’s future incompetent self by issuing an advance directive? In this paper, I use a virtue‐ethical approach to explore this question, focusing on the case of an advance directive for the future self with moderate dementia. First, I examine virtuous attitudes with regard to autonomy and argue that one can manifest vices or ethically undesirable character traits in trying to intervene in the future self’s life. In particular, I argue that this case can manifest vices such as disdainfulness, intellectual arrogance, and self‐dictatorship, which is the vice of trying to control one’s life to an excessive degree, and that a self‐dictator fails to give due moral consideration to the future self’s liberty or agency. I then introduce the Daoist idea of wu‐wei, which recommends embracement of what happens in one’s life, as one of the possible remedies for the overemphasis on the value of autonomy and control.
Public funding of uterus transplantation: Deepening the socio‐moral critique
Authors: Lotz Mianna 
Published: June 2021

AbstractHuman uterus transplantation (UTx)—the most radical and experimental of all current forms of assisted reproduction—gives rise to a range of complex ethical questions, including those related to individual safety, risk, and informed consent. I have argued elsewhere that the wider social impacts and implications of UTx provision must form part of a comprehensive ethical analysis. My socio‐moral critique of UTx provision has been responded to with a number of defences of possible public funding of UTx. In this paper I examine a select number of those defences. These include: that UTx provision would address harms and needs that already exist and as such have priority; that UTx provision is fully compatible with the needed reform of the procreative context in which it would be offered; that UTx provision would not necessarily involve legitimation or endorsement of what are widely agreed to be problematic pronatalist or geneticist norms; and that UTx provision is required as a matter of justice and consistency with other practices. Importantly, defenders are not proposing a ceteris paribus justification of UTx provision; nor do my responses to their arguments represent a comprehensive opposition to UTx. Rather, my more limited purpose here is to show that whatever other defences may be given of publicly funded UTx provision, those considered here do not ultimately succeed and therefore do not allay the concerns underpinning the original socio‐moral critique.
Three‐year monitoring of roadkill trend in a road adjacent to a national park in Panama
Authors: Gálvez Dumas 
Published: June 2021

AbstractRoadkill monitoring can provide important information about spatial and temporal trends on roadkill events. These studies are important for conservation, but there are few examples from Central America. Here, I identified in a road near a national park in Panama that monthly vertebrate roadkill events decreased with increases in temperature and precipitation.Abstract in Spanish is available with online material.
Extraction, structural analysis, and activities of rice bran polysaccharide
Authors: Huang Shiyu , Huang Gangliang 
Published: June 2021

AbstractThe rice bran polysaccharide was extracted from defatted rice bran, and the optimal conditions of the experiment were determined. The chemical structure of rice bran polysaccharide was analyzed by IR and 13C NMR. Three rice bran polysaccharide derivatives were prepared and characterized, namely carboxymethylated rice bran polysaccharide, phosphorylated rice bran polysaccharide, and acetylated rice bran polysaccharide. It showed that the phosphorylated rice bran polysaccharide had good activity.