bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESEARCH OF ARCHITECTURE FORMATION LANDSCAPE THEATERS IN UKRAINE
Authors: Gumennyk Inna 
Published: December 2021

The article is devoted to the problems of landscape theaters architecture formation on the territory of Ukraine in the realities which have developed in the course of typology development and an arrangement of the cultural data and entertaining and leisure establishments in modern conditions.
The article examines the specifics of the landscape theaters location depending on the functional purpose, capacity of the auditorium and attendance level of various theatrical performances in the open air in Ukraine.
Based on the results of professional questionnaires and analysis of statistical data on the theater and concert network in Ukraine, the author proposes 15 factors that shape the modern architecture of Ukrainian landscape theaters. The author investigates how these factors modify the spectator environment and shows the tools and techniques that allow you to create a harmonious space of the theater.
The list of the above factors influencing the formation of the landscape theaters architecture in Ukraine should include such factors as: the capacity of the auditorium; functional purpose of the building; location of the theater; the mode of the auditorium openness and stage; special conditions of the open-air theater location zone.
In addition, the author investigates the following factors in the formation of landscape theaters architecture, such as: organizational schemes of the stage; the configuration of the amphitheater in relation to the stage; ways to evacuate visitors from the auditorium in case of emergencies; determination of the optimal angle of the auditorium; architectural and constructive solution of the theater location (on a natural or anthropogenic basis).
The author analyzes the influence on the formation of the landscape theaters architecture due to the system of the stage layout and arrangement; when using special technological techniques and technical means; by considering the mobility of the theater; under the conditions of synthesis at the location of the stage relative to the spectator amphitheater; using the means of green architecture and design solutions in the organization of theater space.
HISTORICAL DEVELOPMENT OF PALLIATIVE ESTABLISHMENTS IN THE WORLD AND IN UKRAINE
Authors: Piven Anastasiia , Haraborska Yulia 
Published: December 2021

The object of the research is centers of palliative help.
The article of research is historical development of establishments of palliative medicine.
Global environmental problems of today lead to increase in the incidence of population and increase in incurable cases. The problems of terminally ill patients are been dealt with by palliative medicine, which takes care of the situation of such patients and their families. The article deals with the history of development of palliative care facilities in the world - hospices. The situation of creation of such establishments in Ukraine is analyzed, which indicates the need to revise the state regulatory framework for design. The analysis conducted in the article indicates the inconsistency of the current norms and the absence of special normative bases for the design of hospices. Current situation does not allow for proper development of the construction of palliative care facilities. In addition, the main criteria and needs are discussed in the article:

Physical comfort (achieved by creating a home atmosphere in the hospital)
Psychological comfort (achieved using the principle of an individual approach to each patient, taking into account all their needs)
Social comfort (achieved by designing places for communication with other patients, as well as with relatives and friends. It is important that such places possess and create a positive attitude and distract from negative thoughts)

Visual comfort (achieved with the help of thoughtful landscaping and designing places for walks, squares, intimate areas for rest and relaxation, as well as for the hobbies of patients)
UKRAINIAN ACADEMY OF ARCHITECTURE: HISTORY, PROFITS AND LOSSES, EXPECTATIONS AND PROSPECTS
Authors: Puchkov Andrii 
Published: December 2021

An attempt has been made to outline in a historical and chronological way the main features, achievements and problems of the Academy of Architecture in Ukraine, from 1945 to the present. These are the Academy of Architecture of the USSR, transformed in 1945 from the Ukrainian branch of the Academy of Architecture of the USSR (1944), the Academy of Civil Engineering and Architecture of the USSR, transformed from the Academy of Architecture in 1955, the liquidation of this Academy in 1963, the restoration of the Academy in 1992. year in the status of the Ukrainian Academy of Architecture.
Based on the involvement of little-known factual material outlines the activities and practical and theoretical guidelines of the five presidents of the Academy of Architecture - Vladimir Zabolotny (1945-1955), Anatoly Komar (1955-1959), Pavel Bakuma (1959-1963), Valentyn Shtolko (1992–2020), Oleg Sleptsov (since September 2021), as well as the peculiarities of actual achievements and radiant delusions of lost perspectives, unfulfilled desires and urgent needs of the architectural and architectural shops of Ukraine during the last almost eighty years.
Among other things, the achievements of the Academy on the way of researching the architectural heritage of Ukraine, the care of V. Zabolotny for research in this area are shown; highlights the dynamics of transformation of candidate dissertations in architecture from design and descriptive to the actual scientific, as they are now; the range of problems that accompanied the Ukrainian Academy of Architecture after its restoration in 1992 is depicted, as well as the vastness of important scientific and creative achievements of its academics and corresponding members, in particular in the field of publishing basic scientific works; finally, for the first time, it is proposed to illustrate the general picture of the formation and formation of the forms of activity of the Academy of Architecture during its existence; the prospects of further functioning are outlined and aspects of understanding the role of the Ukrainian Academy of Architecture in the modern architectural world, not only the Ukrainian one, are singled out.
Analytical Solutions of Fractional Partial Differential equations for the Second grade fluid Flow
Authors: Ikram Muhammad Danish , Tahir Zuha Binte , Anwar Maira , Asjad Muhammad Imran 
Published: December 2021

This research work is related to unsteady movement of second-grade fluid over an infinite plate.
The governing equations for flow are developed through constitutive relations. Then classical model
extended to fractional order model with power law fractional differential operator. The Laplace
transform (LT) technique is applied to find the analytical results and stated as series satisfy the
boundary conditions. To see physical significance of flow parameters some graphs are displayed.
Recent results from the existing literature are recovered to validate.

Copyright(c) The Authors
Building Information Modelling Technology in Mitigating Cost Overruns and change orders in Construction Projects
Authors: Aldiabat Al-Btoosh Ja’far A. 
Published: December 2021

Variation order (VO) is one of the main issues faced by the construction industry in Jordan. Many researchers had investigated on the causes of VO and proposed procedures to minimize and control this issue; however, the VO is affecting the construction industry badly even at moment. Building Information Modeling (BIM) is a powerful management system that can make a significant difference in the project costs. However, BIM has not been examined as a tool to minimize the VO in Jordan. The main target of this study is to utilize BIM applications in reducing the effect of VO on the governmental projects in Jordan. In order to achieve this target, the researcher has designed a questionnaire to gather data related to VO causes and the BIM capability to solve this problem. The data collected from the questionnaires were analyzed statistically. The result from the analysis found that the consultant initiated the highest VO of 50% followed by the clients and the contractors of 20% and 10% unforeseen variation respectively. Moreover, it is found that BIM Design Applications, Facility Operations Simulation, Exploration Design Scenarios, BIM Design Detection and BIM Quantity Take-off and Cost Estimation were significantly capable of minimizing VO. The results show positive relationship with the application of BIM in minimizing VO in the construction industry in Jordan.
© 2018. JASET, International Scholars and Researchers Association
A peculiaridade do estético e a emancipação humana: a arte em Aristóteles e Lukács
Authors: Dos Santos Rosa Daniele 
Published: December 2021

Este artigo tem por objetivo investigar a especificidade da forma literária em sua relação com a possibilidade de construção de caminhos para a emancipação humana, por meio do estudo da presença, transformação e atualidade dos conceitos aristotélicos na obra lukacsiana, já que para estes dois estetas a arte se coloca como ação humana incontornável para a sua desfetichização. Por meio de um estudo detido de algumas categorias teóricas, apreentaadas principalmente na Poética, de Aristóteles, e na Estética, de Lukács, foi possível compreender como a arte, enquanto expressão das potencialidades humanas, possibilita – além de uma compreensão mais profunda da experiência humana – a contrução de um sentido ao mundo, um sentido ontogênico, base para qualquer possibilidade de transformação.
A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells
Authors: Dong Haibo , Feng Yue , Yang Yang , Hu Yun , Jia Yimin , Yang Shu , Zhao Nannan , Zhao Ruqian 
Published: December 2021

Background:There has been a recent appreciation that some metabolic enzymes can profoundly influence the nature of the immune response produced in macrophages. However, the role of mitochondrial phosphoenolpyruvate carboxykinase (PCK2) in immune response remains unknown. This study aims to investigate the role of PCK2 in lipopolysaccharides (LPS)-induced activation in Kupffer cells.Methods:Inflammatory cytokines were determined by real-time quantitative reverse transcription-polymerase chain action (qRT-PCR) and flow cytometric analysis using a cytometric bead array. Western blotting and immunofluorescence staining were used to determine PCK2 expression and subcellular distribution under confocal laser microscopy. qRT-PCR, flow cytometry, and high-performance liquid chromatography (HPLC) were used to determine mitochondrial function. Pharmacological inhibition, knockdown, and overexpression of PCK2 were used to confirm its function. Co-immunoprecipitation (Co-IP) was performed to determine MAPK/NF-κB phosphorylation.Results:Inflammatory response was significantly increased in LPS-treated mice and Kupffer cells. During the inflammatory process, the protein level of PCK2 was significantly upregulated in Kupffer cells. Interestingly, the localization of PCK2 was mainly in cytosol rather than mitochondria after LPS stimulation. Gain-of-function and loss-of-function analyses found that PCK2 overexpression significantly upregulated the levels of inflammation markers, whereas PCK2 knockdown or inhibition significantly mitigated LPS-induced inflammatory response in Kupffer cells. Furthermore, PCK2 promoted protein phosphorylation of NF-κB and AKT/MAPK, the major signaling pathways, controlling inflammatory cascade activation.Conclusion:We identified a novel function of PCK2 in mediating LPS-induced inflammation and provided mechanistic insights into the regulation of inflammatory response in Kupffer cells. Therefore, PCK2 may serve as a novel therapeutic target for the regulation of Kupffer cells-mediated inflammatory responses.
A Diagnostic Nomogram Based on 18F-FDG PET/CT for Bone Metastasis of Gastric Cancer
Authors: Wu Chunhui , Lin Xiaoping , Li Zhoulei , Chen Zhifeng , Xie Wenhui , Zhang Xiangsong , Wang Xiaoyan 
Published: December 2021

Purpose: To develop an effective diagnostic model for bone metastasis of gastric cancer by combining 18F-FDG PET/CT and clinical data.Materials and Methods: A total of 212 gastric cancer patients with abnormal bone imaging scans based on 18F-FDG PET/CT were retrospectively enrolled between September 2009 and March 2020. Risk factors for bone metastasis of gastric cancer were identified by multivariate logistic regression analysis and used to create a nomogram. The performance of the nomogram was evaluated by using receiver operating characteristic curves and calibration plots.Results: The diagnostic power of the binary logistic regression model incorporating skeleton-related symptoms, anemia, the SUVmax of bone lesions, bone changes, the location of bone lesions, ALP, LDH, CEA, and CA19-9 was significantly higher than that of the model using only clinical factors (p = 0.008). The diagnostic model for bone metastasis of gastric cancer using a combination of clinical and imaging data showed an appropriate goodness of fit according to a calibration test (p = 0.294) and good discriminating ability (AUC = 0.925).Conclusions: The diagnostic model combined with the 18F-FDG PET/CT findings and clinical data showed a better diagnosis performance for bone metastasis of gastric cancer than the other studied models. Compared with the model using clinical factors alone, the additional 18F-FDG PET/CT findings could improve the diagnostic efficacy of identifying bone metastases in gastric cancer.
The Appropriateness Criteria of Abdominal Fat Measurement at the Level of the L1-L2 Intervertebral Disc in Patients With Obesity
Authors: Sun Jing , Lv Han , Zhang Meng , Li Mengyi , Zhao Lei , Zeng Na , Liu Yawen , Wei Xuan , Chen Qian , Ren Pengling , Liu Yang , Zhang Peng , Yang Zhenghan , Zhang Zhongtao , Wang Zhenchang 
Published: December 2021

BackgroundIn this study, we proposed to use MR images at L1-L2 (lumbar) intervertebral disc level to measure abdominal fat area in patients with obesity. The quantitative results would provide evidence for the individualized assessment of the severity of obesity.MethodsAll patients in the IRB-approved database of Beijing Friendship Hospital who underwent bariatric surgery between November 2017 and November 2019 were recruited. We retrospectively reviewed upper abdominal magnetic resonance (MR) data before surgery. We analyzed the correlation and consistency of the area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) measured at the L1-L2 and L2-L3 levels on MR images. We randomly distributed the cases into prediction model training data and testing data at a ratio of 7:3.ResultsTwo hundred and forty-five subjects were included. The ASAT and VAT results within the L1-L2 and L2-L3 levels were very similar and highly correlated (maleASAT: r=0.98, femaleASAT: r=0.93; maleVAT: r=0.91, femaleVAT: r=0.88). There was no substantial systematic deviation among the results at the two levels, except for the ASAT results in males. The intraclass correlation coefficients (ICCs) were 0.91 and 0.93 for maleASAT and femaleASAT, and 0.88 and 0.87 for maleVAT and femaleVAT, respectively. The ASAT/VAT area at the L2-L3 level was well predicted. The coefficient β of linear regression that predicted L2-L3 ASAT from L1-L2 ASAT was 1.11 for males and 0.99 for females. The R-squares were 0.97 and 0.91, respectively. For VAT prediction, the coefficient β was 1.02 for males and 0.96 for females. The R-squares were 0.82 and 0.77, respectively.ConclusionFor patients with obesity, the L1-L2 intervertebral disc level can be used as the substitution of L2-L3 level in abdominal fat measurement.
Baseline Characteristics of Mitochondrial DNA and Mutations Associated With Short-Term Posttreatment CD4+T-Cell Recovery in Chinese People With HIV
Authors: Liu Anni , Wei Qian , Lin Haijiang , Ding Yingying , Sun Yan V. , Zhao Dan , He Jiayu , Ma Zhonghui , Li Feihu , Zhou Sujuan , Chen Xiaoxiao , Shen Weiwei , Gao Meiyang , He Na 
Published: December 2021

BackgroundMitochondrial DNA (mtDNA) profiles and contributions of mtDNA variants to CD4+T-cell recovery in Euramerican people living with HIV (PLWH) may not be transferred to East-Asian PLWH, highlighting the need to consider more regional studies. We aimed to identify mtDNA characteristics and mutations that explain the variability of short-term CD4+T-cell recovery in East-Asian PLWH.MethodEight hundred fifty-six newly reported antiretroviral therapy (ART)-naïve Chinese PLWH from the Comparative HIV and Aging Research in Taizhou (CHART) cohort (Zhejiang Province, Eastern China) were enrolled. MtDNA was extracted from peripheral whole blood of those PLWH at HIV diagnosis, amplified, and sequenced using polymerase chain reaction and gene array. Characterization metrics such as mutational diversity and momentum were developed to delineate baseline mtDNA mutational patterns in ART-naïve PLWH. The associations between mtDNA genome-wide single nucleotide variants and CD4+T-cell recovery after short-term (within ~48 weeks) ART in 724 PLWH were examined using bootstrapping median regressions.ResultsOf 856 participants, 74.18% and 25.82% were male and female, respectively. The median age was 37 years; 94.51% were of the major Han ethnicity, and 69.04% and 28.62% were of the heterosexual and homosexual transmission, respectively. We identified 2,352 types of mtDNA mutations and mtDNA regions D-loop, ND5, CYB, or RNR1 with highest mutational diversity or volume. Female PLWH rather than male PLWH at the baseline showed remarkable age-related uptrends of momentum and mutational diversity as well as correlations between CD4+T &lt;200 (cells/μl) and age-related uptrends of mutational diversity in many mtDNA regions. After adjustments of important sociodemographic and clinical variables, m.1005T&gt;C, m.1824T&gt;C, m.3394T&gt;C, m.4491G&gt;A, m.7828A&gt;G, m.9814T&gt;C, m.10586G&gt;A, m.12338T&gt;C, m.13708G&gt;A, and m.14308T&gt;C (at the Bonferroni-corrected significance) were negatively associated with short-term CD4+T-cell recovery whereas m.93A&gt;G, m.15218A&gt;G, and m.16399A&gt;G were positively associated with short-term CD4+T-cell recovery.ConclusionOur baseline mtDNA characterization stresses the attention to East-Asian female PLWH at risk of CD4+T-cell loss-related aging and noncommunicable chronic diseases. Furthermore, mtDNA variants identified in regression analyses account for heterogeneity in short-term CD4+T-cell recovery of East-Asian PLWH. These results may help individualize the East-Asian immune recovery strategies under complicated HIV management caused by CD4+T-cell loss.
The Associations of Caesarean Delivery With Risk of Wheezing Diseases and Changes of T Cells in Children
Authors: Lin Jilei , Yuan Shuhua , Dong Bin , Zhang Jing , Zhang Lei , Wu Jinhong , Chen Jiande , Tang Mingyu , Zhang Bin , Wang Hansong , Dai Yuanyuan , Liu Shijian , Hu Yabin , Qi Xinyi , Xu Liangye , Zhao Liebin , Yin Yong 
Published: December 2021

ObjectivesThis study aimed to assess the associations of caesarean delivery (CD) with risk of wheezing diseases and changes of immune cells in children.DesignThe cross-sectional study was conducted between May, 2020 and April, 2021.Setting and participantsThe study was conducted in Shanghai Children’s Medical Center, Shanghai, China. A total of 2079 children with a mean age of 36.97 ± 40.27 months and their guardians were included in the present study via face-to-face inquiry and physical examination by clinicians.MethodsLogistic regression was applied to estimate odds ratio (ORs) and 95% confidence intervals (CIs) for the association between CD and first episode of wheezing (FEW) or asthma. Models were adjusted for premature or full-term delivery, exclusive breastfeeding (at least 4 months) or not.ResultsAmong the 2079 children, 987 children (47.47%) were born by CD and 1092 (52.53%) by vaginal delivery (VD). Children delivered by caesarean had significantly lower gestational age (P&lt;0.01) compared with those who delivered vaginally. Our results also showed that CD was related to increased risk of FEW by the age of 3(adjusted OR 1.50, 95%CI 1.06, 2.12) and increased tendency to develop asthma by the age of 4 (adjusted OR 3.16, 95%CI 1.25, 9.01). The subgroup analysis revealed that the negative effects of CD on asthma were more obvious in children without exclusive breastfeeding (adjusted OR 4.93, 95%CI 1.53, 21.96) or without postnatal smoking exposure (adjusted OR 3.58, 95%CI 1.20, 13.13). Furthermore, compared with children born through VD, a significant change of the T cells (increased proportion of CD4+ T cells and decreased number and proportion of CD8+ T cells) were observed before the age of one in the CD group. However, the changes were insignificant in children over 1 year old.ConclusionsThis study showed age-dependent associations of CD with asthma and FEW in offspring. Moreover, CD appeared to have an effect on the cellular immunity in infants, the disorder of which may contribute to the development of asthma in children.
Portal Vein Thrombosis Might Develop by COVID-19 Infection or Vaccination: A Systematic Review of Case-Report Studies
Authors: Kheyrandish Setare , Rastgar Amirhossein , Arab-Zozani Morteza , Sarab Gholamreza Anani 
Published: December 2021

Background and Objective: Infection by the novel coronavirus disease 2019 (COVID-19) has been associated with different types of thrombotic complications same as portal vein thrombosis (PVT). However, by emerging vaccines of COVID, the thrombosis did not seem to be concerning anymore. Until new findings showed that, the vaccine of COVID itself can cause PVT.Method: We performed an electronic search in PubMed, Scopus, and Web of Sciences to evaluate the possibility of occurring PVT due to infection and vaccination of COVID-19. The results were reported in a narrative method and categorized into tables.Result: Overall, 40 cases of PVT from 34 studies were reviewed in this article. The prevalence of PVT following COVID-19 was more remarkable in males. However, it was more common in females after vaccinations of COVID-19 in the reviewed cases. Regardless of etiology, 20 of PVT cases reviewed in this article had at least one comorbidity. The most common clinical presentation was abdominal pain (AP). After anticoagulant therapies, most of the patients improved or discharged.Conclusion: As long as the laboratory findings are not appropriate enough to predict PVT, the diagnosis of this complication with whatever underlying reason is challengeable, while rapid diagnosis and treatment of that are vital. Therefore, by providing available data in an organized way, we aimed to prepare the information of infected patients for better and easier future diagnosis of PVT in new cases.