bluuebunny/crossref_metadata_2025_split huggingface dataset:
Native American social work – Including family and community
Authors: Swanson Shanley , Nygård Reidunn H , Saus Merete 
Published: July 2021

Summary This study investigates family involvement and culturally informed social work in Native American communities. The study was conducted in Native American communities in Montana, USA. Twenty-three Native American social work professionals participated in qualitative interviews. Analyses draw on theory of historical trauma and family involvement in indigenous social. Throughout the study, indigenous methodology has been a central principle. Findings Among social workers, there is a common understanding that social work should involve family and community if it is to be culturally informed. Social work professionals talk of family involvement in indigenous social work as “common sense.” For the Native American social work professionals interviewed, the following tenets are all “common sense”: (1) family and community belonging are important aspects of Native American culture; 2) oppression and colonization had a negative impact on family, community, and tribal relations; and (3) social work has an obligation to restore family, community, and tribal relations. Application Social work has a responsibility to connect culture, trauma, and the resolution of trauma. Furthermore, family and community involvement plays a core part in restoration and resilience processes, healing historical trauma caused by the colonization. Hence, in order to provide culturally competent care, social work practices serving Native American clients should involve family and community. Mainstream social work does not sufficiently build on family involvement as an ideological foundation for qualitatively good social work. We argue that social work curricula impacting Native clients could benefit from the experience and knowledge of these Native American social workers.
Exploring the impact of pharmacist comprehensive annual care plans on perceived quality of chronic illness care by patients in Alberta, Canada
Authors: Necyk Candace , Johnson Jeffrey A. , Tsuyuki Ross T. , Eurich Dean T. 
Published: July 2021

Background: In 2012, the Government of Alberta introduced a funding program to remunerate pharmacists to develop a comprehensive annual care plan (CACP) for patients with complex needs. The objective of this study is to explore patients’ perceptions of the care they received through the pharmacist CACP program in Alberta. Methods: We invited 3442 patients who received a pharmacist-billed CACP within the previous 3 months and 6888 matched controls across Alberta to complete an online questionnaire. The questionnaire consisted of the short version Patient Assessment of Chronic Illness Care (PACIC-11), with 3 additional pharmacy-specific assessment questions added. Additional questions related to health status and demographics were also included. Results: Overall, most patients indicated a low level of chronic illness care by pharmacists, with few differences noted between CACP patients and non-CACP controls. Of note, controls reported higher quality of care for 5 domains within the adapted PACIC-like tool compared with CACP patients ( p < 0.05 for all). Interestingly, only 79 (44%) of CACP patients reported that they had received a CACP, whereas only 192 (66%) of control patients reported that they did not receive a care plan. In a sensitivity analysis including only these respondents, individuals who received a CACP perceived a significantly higher quality of chronic illness care across all PACIC domains. Conclusion: Overall, chronic illness care incentivized by the pharmacist CACP program in Alberta is perceived to be moderate to low. When limited to respondents who explicitly recognized receiving the service or not, the perceptions of quality of care were more positive. This suggests that better implementation of CACP by pharmacists may be associated with improved quality of care and that some redesign is needed to engage patients more. Can Pharm J (Ott) 2021;154:xx-xx.
Diagnosis of Anosmia and Hyposmia: A Systematic Review
Authors: Saltagi Abdul K. , Saltagi Mohamad Z. , Nag Amit K. , Wu Arthur W. , Higgins Thomas S. , Knisely Anna , Ting Jonathan Y. , Illing Elisa A. 
Published: July 2021

Background Anosmia and hyposmia have many etiologies, including trauma, chronic sinusitis, neoplasms, and respiratory viral infections such as rhinovirus and SARS-CoV-2. We aimed to systematically review the literature on the diagnostic evaluation of anosmia/hyposmia. Methods PubMed, EMBASE, and Cochrane databases were searched for articles published since January 1990 using terms combined with Medical Subject Headings (MeSH). We included articles evaluating diagnostic modalities for anosmia, written in the English language, used original data, and had two or more patients. Results A total of 2065 unique titles were returned upon the initial search. Of these, 226 abstracts were examined, yielding 27 full-text articles meeting inclusion criteria (Level of evidence ranging from 1 to 4; most level 2). The studies included a total of 13,577 patients. The most utilized diagnostic tools were orthonasal smell tests (such as the Sniffin’ Sticks and the UPSIT, along with validated abridged smell tests). Though various imaging modalities (including MRI and CT) were frequently mentioned in the workup of olfactory dysfunction, routine imaging was not used to primarily diagnose smell loss. Conclusion The literature includes several studies on validity and reliability for various smell tests in diagnosing anosmia. Along with a thorough history and physical, validated orthonasal smell tests should be part of the workup of the patient with suspected olfactory dysfunction. The most widely studied modality was MRI, but criteria for the timing and sequence of imaging modalities was heterogenous.
Three-Dimensional Imaging of Displaced Intra-articular Calcaneal Fractures Correlates With the Perioperative Diagnosis
Authors: Misselyn Dominique , Schepers Tim , Buckley Richard , Swords Michael , Matricali Giovanni , Nijs Stefaan 
Published: July 2021

Background: Intra-articular calcaneal fractures are complex injuries, and CT imaging has become the standard imaging in the preoperative assessment. Most classifications of these fractures are CT-based but have been associated with limited interobserver agreement. Three-dimensional imaging has become widely available and may give a better perspective but often with 1 image only. There is not much evidence of the added value of this imaging, compared with the CT imaging. Methods: Eight experienced trauma surgeons assessed 28 different intra-articular calcaneal fractures, on conventional radiology (CR), CT, and 3-D imaging. All had extensive experience in the diagnosis and treatment of this difficult injury. The main questions concerned Sanders classification, the severity of the injury and the difficulty of the operative procedure, choice of approach, and choice of procedure. Results: The classical 2-D CT imaging of the fractures were associated with a higher Sanders classification ranking, compared with the 3-D imaging scores. However, the interobserver agreement, as measured by the Fleiss kappa, was low for all 3 imaging modalities. We found more frequent Sanders III and IV classifications with CT scan imaging compared with 3-D imaging or CR. The scores obtained after assessing 3-D imaging were also not statistically significantly different from the scores of a consensus achieved by 2 authors and based on the 3 imaging modalities and the perioperative diagnosis. Conclusion: The 3-D imaging may result in a more realistic view, reducing the frequency of classifying Sanders III fractures than with the 2-D CT imaging series. 3-D imaging may be more reliable than CT in the planning of operative treatment of displaced intra-articular calcaneal fractures. Level of Evidence: Level III.
20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment
Authors: Margolin Leon , Luchins Jeremy , Margolin Daniel , Margolin Michelle , Lefkowitz Sanford 
Published: July 2021

Objectives and Setting. As the lethal COVID-19 pandemic enters its second year, the need for effective modalities of alleviation remains urgent. This includes modalities that can readily be used by the public to reduce disease spread and severity. Such preventive measures and early-stage treatments may temper the immediacy of demand for advanced anti-COVID measures (drugs, antibodies, vaccines) and help relieve strain also on other health system resources. Design and Participants. We present results of a clinical study with a multi-component OTC “core formulation” regimen used in a multiply exposed adult population. Analysis of clinical outcome data from our sample of over 100 subjects − comprised of roughly equal sized regimen-compliant (test) and non-compliant (control) groups meeting equivalent inclusion criteria − demonstrates a strong statistical significance in favor of use of the core formulations. Results. While both groups were moderate in size, the difference between them in outcomes over the 20-week study period was large and stark: Just under 4% of the compliant test group presented flu-like symptoms, but none of the test group was COVID-positive; whereas 20% of the non-compliant control group presented flu-like symptoms, three-quarters of whom (15% overall of the control group) were COVID-positive. Conclusions. Offering a low cost, readily implemented anti-viral approach, the study regimen may serve, at the least, as a stopgap modality and, perhaps, as a useful tool in combatting the pandemic.
The impact of the disease burden on the quality of life of cluster headache patients
Authors: Pohl Heiko , Gantenbein Andreas R , Sandor Peter S , Schoenen Jean , Andrée Colette 
Published: July 2021

Background: Cluster headache cannot be cured, and not all attacks can be aborted or prevented. Nevertheless, therapeutic guidelines focus solely on the attacks and ignore reverberations of the disorder on patients’ lives. However, it is likely that not only pain reduces patients’ quality of life (QoL). Objective: To investigate whether the interictal burden independently influence the QoL of subjects suffering from cluster headache. Methods: In this cross-sectional study, we asked patients with a self-reported cluster headache diagnosis to answer a modified EUROLIGHT questionnaire that included the EURO-HIS QoL scale. We built a generalised linear model and included the QoL as the dependent variable. Independent variables comprised both the ictal and the interictal burden. Results: The data of 625 participants entered the analysis. Several aspects of the interictal burden independently reduced the QoL. Among them were fear of pain, self-concealment, and private life difficulties due to the disorder. Conclusion: Both the ictal and the interictal burden of cluster headache independently reduce patients’ QoL. We advocate adopting a more holistic approach to cluster headache management extending the focus towards the afflicted person and their QoL, which would generate novel therapeutic goals and strategies, complementary to treating and preventing cluster headache attacks.
Age-related differences in resting state functional connectivity in pediatric migraine
Authors: Bell Tiffany , Khaira Akashroop , Stokoe Mehak , Webb Megan , Noel Melanie , Amoozegar Farnaz , Harris Ashley D. 
Published: July 2021

Abstract
Background
Migraine affects roughly 10% of youth aged 5–15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains of adult migraine sufferers. This study aims to investigate the effects of migraine on resting-state functional connectivity during the period of transition from childhood to adolescence, a critical period of brain development and the time when rates of pediatric chronic pain spikes.

Methods
Using independent component analysis, we compared resting state network spatial maps and power spectra between youth with migraine aged 7–15 and age-matched controls. Statistical comparisons were conducted using a MANCOVA analysis.

Results
We show (1) group by age interaction effects on connectivity in the visual and salience networks, group by sex interaction effects on connectivity in the default mode network and group by pubertal status interaction effects on connectivity in visual and frontal parietal networks, and (2) relationships between connectivity in the visual networks and the migraine cycle, and age by cycle interaction effects on connectivity in the visual, default mode and sensorimotor networks.

Conclusions
We demonstrate that brain alterations begin early in youth with migraine and are modulated by development. This highlights the need for further study into the neural mechanisms of migraine in youth specifically, to aid in the development of more effective treatments.
Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study
Authors: Hou Chenyang , Hou Qingzhi , Xie Xing , Wang Huifeng , Chen Yueliang , Lu Tingxi , Wu Qunying , Liang Yongcong , Hu Yanling , Mao Yuang 
Published: July 2021

Abstract
Background
Previous observational studies have provided conflicting results on the association between serum iron status and the risk of breast cancer. Considering the relevance of this relationship to breast cancer prevention, its elucidation is warranted.

Object
We used a two-sample Mendelian randomisation (MR) study to explore the causal relationship between serum iron status and the risk of breast cancer.

Method
To select single nucleotide polymorphisms (SNPs) that could be used as instrumental variables for iron status, we used the Genetics of Iron Status consortium, which includes 11 discovery and 8 replication cohorts, encompassing 48,972 individuals of European descent. Moreover, we used the OncoArray network to select SNPs that could be considered instrumental variables for the outcome of interest (breast cancer); this dataset included 122,977 individuals of European descent with breast cancer and 105,974 peers without breast cancer. Both conservative (SNPs associated with overall iron status markers) and liberal (SNPs associated with the levels of at least one iron status marker) approaches were used as part of the MR analysis. For the former, we used an inverse-variance weighted (IVW) method, whereas for the latter, we used the IVW, MR-Egger regression, weighted median and simple mode methods.

Results
When the conservative approach was used, iron status showed no significant association with the risk of breast cancer or any of its subtypes. However, when the liberal approach was used, transferrin levels were found to be positively associated with the risk of ER-negative breast cancer based on the simple mode method (OR for MR, 1.225; 95% CI, 1.064, 1.410; P = 0.030). Nevertheless, the levels of the other iron status markers showed no association with the risk of breast cancer or its subtypes (P > 0.05).

Conclusion
In our MR study, the liberal approach suggested that changes in the concentration of transferrin could increase the risk of ER-negative breast cancer, although the levels of other iron status markers had no effect on the risk of breast cancer or its subtypes. This should be verified in future studies.
Penile Mondor’s in a Covid-19 patient on prophylactic anti-thrombosis with rivaroxaban: a case report
Authors: Eren Murat Tuğrul , Özveri Hakan , Kurtoğlu Hilal 
Published: July 2021

Abstract
Background
Penile Mondor’s disease (PMD) is thrombophlebitis of the superficial dorsal vein of the penis. Following the occurrence of thrombotic events in the affected veins, the lumen often becomes occluded with fibrin and inflammatory cells. A hyper-coagulative state is one of the underlying causes although most cases of PMD are idiopathic. Coronavirus disease-2019 infection (COVID-19) is associated with frequent thrombotic events. Inflammation and thrombosis play a central role in the course and outcome of COVID-19, which can predispose to both venous and arterial thromboembolism. In this report, we present a 33-year-old male patient diagnosed with PMD during the subacute phase of COVID-19 infection while on prophylactic antithrombotic treatment.

Case Presentation
A 33-year-old male patient was diagnosed as PMD which occurred during the subacute phase of COVID-19 infection, while he was on active treatment of COVID-19 by prophylactic antithrombotic Rivaroxaban 15 mg therapy and curative antiviral medication. There was no recent sexual intercourse or trauma to the genitals. His PCR test for COVID-19 had become negative, and antibody test was positive at the time of his PMD’s onset. Rivaroxaban was replaced by Enoxaparin (8000 IU/0.8 ml.), a low molecular weight heparin administered subcutaneously and twice daily. On the third day of this medication, all coagulative measurements returned to normal. PMD disappeared in the second week.

Conclusion
Low-dose Rivaroxaban 15 mg is not safe for some COVID-19-associated thromboembolism prophylaxis, and careful follow-up is critical due to the possibility of a wide range of pathologic thrombotic manifestations in COVID-19 infection.
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
Authors: Feng Song , Heath Emily , Jefferson Brett , Joslyn Cliff , Kvinge Henry , Mitchell Hugh D. , Praggastis Brenda , Eisfeld Amie J. , Sims Amy C. , Thackray Larissa B. , Fan Shufang , Walters Kevin B. , Halfmann Peter J. , Westhoff-Smith Danielle , Tan Qing , Menachery Vineet D. , Sheahan Timothy P. , Cockrell Adam S. , Kocher Jacob F. , Stratton Kelly G. , Heller Natalie C. , Bramer Lisa M. , Diamond Michael S. , Baric Ralph S. , Waters Katrina M. , Kawaoka Yoshihiro , McDermott Jason E. , Purvine Emilie 
Published: July 2021

Abstract
Background
Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data. However, graphs do not natively capture the multi-way relationships present among genes and proteins in biological systems. Hypergraphs are generalizations of graphs that naturally model multi-way relationships and have shown promise in modeling systems such as protein complexes and metabolic reactions. In this paper we seek to understand how hypergraphs can more faithfully identify, and potentially predict, important genes based on complex relationships inferred from genomic expression data sets.

Results
We compiled a novel data set of transcriptional host response to pathogenic viral infections and formulated relationships between genes as a hypergraph where hyperedges represent significantly perturbed genes, and vertices represent individual biological samples with specific experimental conditions. We find that hypergraph betweenness centrality is a superior method for identification of genes important to viral response when compared with graph centrality.

Conclusions
Our results demonstrate the utility of using hypergraphs to represent complex biological systems and highlight central important responses in common to a variety of highly pathogenic viruses.
Feature selection and causal analysis for microbiome studies in the presence of confounding using standardization
Authors: Goren Emily , Wang Chong , He Zhulin , Sheflin Amy M. , Chiniquy Dawn , Prenni Jessica E. , Tringe Susannah , Schachtman Daniel P. , Liu Peng 
Published: July 2021

AbstractBackgroundMicrobiome studies have uncovered associations between microbes and human, animal, and plant health outcomes. This has led to an interest in developing microbial interventions for treatment of disease and optimization of crop yields which requires identification of microbiome features that impact the outcome in the population of interest. That task is challenging because of the high dimensionality of microbiome data and the confounding that results from the complex and dynamic interactions among host, environment, and microbiome. In the presence of such confounding, variable selection and estimation procedures may have unsatisfactory performance in identifying microbial features with an effect on the outcome.ResultsIn this manuscript, we aim to estimate population-level effects of individual microbiome features while controlling for confounding by a categorical variable. Due to the high dimensionality and confounding-induced correlation between features, we propose feature screening, selection, and estimation conditional on each stratum of the confounder followed by a standardization approach to estimation of population-level effects of individual features. Comprehensive simulation studies demonstrate the advantages of our approach in recovering relevant features. Utilizing a potential-outcomes framework, we outline assumptions required to ascribe causal, rather than associational, interpretations to the identified microbiome effects. We conducted an agricultural study of the rhizosphere microbiome of sorghum in which nitrogen fertilizer application is a confounding variable. In this study, the proposed approach identified microbial taxa that are consistent with biological understanding of potential plant-microbe interactions.ConclusionsStandardization enables more accurate identification of individual microbiome features with an effect on the outcome of interest compared to other variable selection and estimation procedures when there is confounding by a categorical variable.
Assessment of habitat change on bird diversity and bird–habitat network of a Coral Island, South China Sea
Authors: Li Yingcan , Chen Zhiwen , Peng Chao , Huang Guangchuan , Niu Hongyu , Zhang Hongmao 
Published: July 2021

Abstract
Background
Understanding how island ecosystems change across habitats is a major challenge in ecological conservation under the conditions of habitat degradation. According to a 2-year investigation on Dong Island of the Paracel Islands, South China Sea, we assessed the roles of different habitats at the species level and community level of birds using topological and network analysis.

Results
In addition to the thousands of Sula sula (a large-sized arboreal seabird) inhabiting the forests, there were 56 other bird species were recorded, representing 23 families and 12 orders, ranging in habitats of wetlands, forests, shrublands, grasslands, and/or beaches. The bird–habitat network had high nestedness, and bird species showed obvious clustering distribution. Integrated topological and network analysis showed that wetlands had a high contribution to species diversity and network structure, and it was a cluster center of migrant birds. Forests and grasslands were species hub and connector respectively, and forests were also the key habitat for residents. Beaches and shrublands were peripherals. The loss of wetlands and forests will result in a sharp reduction of species richness, and even make the S. sula, and most of the resident birds, become locally extinct.

Conclusions
These results suggest that the wetland and forest habitats on the focal island are key important for migrant birds and resident birds respectively, and therefore much more attention should be paid to conservation of the focal island ecosystems.