bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and Facilitative Factors in the Implementation of Workplace Health Promotion Activities in Small and Medium-Sized Enterprises: A Qualitative Study
Authors: Saito Junko , Odawara Miyuki , Takahashi Hirokazu , Fujimori Maiko , Yaguchi-Saito Akiko , Inoue Manami , Uchitomi Yosuke , Shimazu Taichi 
Published: September 2021

Abstract
Background: It is reasonable to target small and medium-sized enterprises (SMEs) as a workplace to promote the implementation of evidence-based interventions (EBIs) for reducing health inequalities. Previous literature reveals various barriers that SMEs face during implementation, such as a lack of time, accessibility, and resources. However, few studies have comprehensively examined those influential factors at multi-levels. This study aims to identify the factors influencing the implementation of non-communicable disease prevention activities (tobacco, alcohol, diet, physical activity, and health check-up) in SMEs using Consolidated Framework for Implementation Research (CFIR). Methods: We conducted 15 semi-structured interviews with health managers and/or employers in 15 enterprise, and four focus groups among public health nurses/nutritionists of health insurers who support SMEs in four prefectures across Japan. A qualitative content analysis by a deductive directed approach was performed. After coding the interview transcript text into the CFIR framework constructs by two independent researchers, the coding results were compared and revised in each enterprise until an agreement was reached.Results: Of the 39 CFIR constructs, 25 were facilitative and 7 were inhibitory for workplace health promotion implementation in SMEs, which were across individual, internal, and external levels. In particular, the leadership engagement of employers in implementing the workplace health promotion activities was identified as a fundamental factor which may influence other facilitators, including “access to knowledge and information,” “relative priority,” “learning climate,” at organizational level, and “self-efficacy” at health manager level. The main barrier was the beliefs held by the employer/manager that “health management is one's own responsibility.” Conclusions: Multi-level factors influencing the implementation of non-communicable diseases prevention activities in SMEs were identified. In resource-poor settings, strong endorsement and support, and positive feedback from employers would be important for health managers and employees to be highly motivated and promote or participate in health promotion. Future studies are needed to develop context-specific strategies based on identified barriers and facilitative factors, and empirically evaluate them, which would contribute to narrowing the inequalities in worksite health promotion implementation by company size.
Comprehensive Analysis of Hub Genes In Prostate Cancer
Authors: Yang Zhi , MI JUN 
Published: September 2021

Abstract
Abstract：The present study aims to explore the involvement of hub genes in prostate cancer (PCa). Three series were used in this study: GSE46602, GSE5377, and GSE8511 from GPL570 platform in the Gene Expression Omnibus and the other resources from The Cancer Genome Atlas and UCSC Xena. A total of 47 differentially expressed genes (DEGs)from 77 patients with PCa and normal individuals were selected in this study. Cytoscape revealed 21 central nodes with 20 edges from the 47 DEGs genes. PCA3, SIM2, AMACR, HOXB6, ERG and TOP2A were overexpressed and correlated in prostate cancer cells and tumors. These findings suggest that PCA3 and TOP2A might help explore the prognosis and diagnostic markers of PCa.Purpose: The gene audition was completed using R software and Venn diagrams. The outcome, Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes preliminary analyses of differentially expressed genes (DEGs) were performed using the R software. A string image was obtained using the Search Tool for the Retrieval of Interacting Genes. The protein–protein interaction (PPI) network was examined using Cytoscape software. The corrplot package was used to analyze the correlation of genes. Human Protein Atlas was used to confirm the protein levels. Univariate Cox regression was used to analyze whether these genes were related to survival. UALCAN was used to confirm the effect of these genes on patient survival[8].Results: A total of 47 differentially expressed genes from 77 patients with PCa and normal individuals were selected in this study. Cytoscape revealed 21 central nodes with 20 edges from the 47 DEGs genes. The overexpressed genes as PCA3, SIM2, AMACR, HOXB6, ERG and TOP2A were selected based on the cell cycle pathway. A significant correlation was found among the 6 DEGs. The transcription levels and protein levels of these genes were verified in cells and human tissue samples. The overall survival for these genes was analyzed using univariate Cox regression, UALCAN and UCSC Xena.Conclusion: PCA3, SIM2, AMACR, HOXB6, ERG and TOP2A were overexpressed and correlated in prostate cancer cells and tumors. PCA3 and TOP2A might help explore the prognosis and diagnostic markers of PCa.
Systematic Analysis of tRNA-Derived Small RNAs Reveals Effects of Xuefu-Zhuyu Decoction on Hippocampus of Rats after Traumatic Brain Injury
Authors: Dai Feng , Tang Tao , Lu Ruohuang , Li Pengfei , Feng Dandan , Hu Mingrui , Wang Yang , Gan Pingping 
Published: September 2021

Abstract
Background: Traumatic brain injury (TBI) is one of the most common neurosurgical diseases which refers to brain function impairment or brain pathological changes induced by external causes. A traditional Chinese medicine, Xuefu Zhuyu Decoction (XFZYD), has been indicated to harbor therapeutic property against TBI. Transfer RNA (tRNA)-derived small RNAs i.e., tsRNAs (a group of small RNAs derived from tRNAs) are multifunctional regulatory non-coding RNAs generated under pressure and implicated in the progression of TBI.Methods: TBI model was successfully constructed by using of rats. Further using sequencing and omics to identify novel tsRNAs as drug targets for XFZYD therapy against TBI in rat hippocampus. qPCR assay was used to further verify the experimental results. GO analyzed the signaling pathways of downstream target genes of tsRNA in XFZYD regulated TBI model. qPCR was used to detect the influence of over-expressed tsRNA mimic/inhibitor on their target genes in PC12 cell.Results: Our RNA-Seq data illustrates that 11 tsRNAs were mediated by the XFZYD. The experimental data revealed AS-tDR-002004 and AS-tDR-002583 as potential targets for XFZYD therapy and influenced TBI via the cadherin signaling pathway, cocaine addiction, circadian entrainment and nicotine pharmacodynamics pathway. We also confirm that Pi4kb, Mlh3, Pcdh9, and Ppp1cb were targets genes of 2 XFZYD regulated tsRNAs in hippocampus of rat model and PC12 cells. Furthermore, biological function analysis revealing potential therapeutic effects of tsRNAs, and results found Mapk1, Gnai1 was the related genes of for XFZYD therapy against TBI.Conclusion: Our work successfully illuminates the efficiency of XFZYD for the treatment of TBI. The experimental data revealed AS-tDR-002004 and AS-tDR-002583 as potential targets for XFZYD therapy and influenced TBI via the cadherin signaling pathway, cocaine addiction, circadian entrainment and nicotine pharmacodynamics pathway in TBI rat model.
Treatment of Geriatric Acetabular Anterior Fractures: Role of “Frame and Buttress”
Authors: Wan Yizhou , Ma Yan , Yao Sheng , Zeng Lian , Wang Yulong , Huang Guixiong , Qu Yanzhen , Cao ShaoMing , Chen Kaifang , Guo Xiaodong 
Published: September 2021

Abstract
Background: As the rate of geriatric acetabular fractures was increasing gradually and accompanied with the quadrilateral surface(QLS) involved resulting by impacting from the head of femur, which usually leaded to the dislocation/subluxation of the head of femur and intra-pelvic medial displacement of the QLS. Traditionally, applying an infra-pectineal buttress plate in the true pelvis to resist the protrusive fragments of the QLS, however, these plates with small contact area could not provide enough buttress effect to age-related fractures. This study was to evaluate the “frame and buttress” fixation strategy for treatment of geriatric acetabular anterior fractures(GAAF).Methods: A cohort of 28 patients with acetabular fractures involving QLS were managed operatively with the “frame and buttress” fixation strategy with a single pelvic anterior approach. 7 cases were transverse, 3 cases were posterior column, 8 cases were associated both columns, 4 cases were anterior posterior hemi-transverse and 6 cases were T-type patterns fracture. The quality of reduction, functional outcomes and complicates were recorded for analyzing.Results: Functional outcomes were 15 cases in excellent; 9 cases were good; 3 cases were fair, and 1 case was poor. The quality of surgical reduction was evaluated by the Matta score system, which was graded as excellent in 17 cases, good in 9 cases and poor in 2 cases, respectively. No loss or failure of internal fixation, no second dislocation/subluxation of femoral head and no complications like infection were observed.Conclusions: The “frame and buttress” fixation strategy provided firm method for treating GAAF, the “frame” formed rigid fixation structure for acetabular fractures and the “buttress” resisted protrusive QLS.
Prevalence and Associated Factors of Gender Based Violence Among Baso High School Female Students, 2020.
Authors: Mingude Alemu Basazin , Dejene Tadesse Mamo 
Published: September 2021

Abstract
Background: Gender-based violence (GBV) is a common reproductive health problem especially in developing countries. It is still the first research priority area in Africa that is identified by World Health Organization. The main aim of this study was to identify the prevalence and determinants of Gender Based Violence among Baso high school female students in Debre Berhan town, Ethiopia.Methods: An institutional based cross-sectional study was conducted in Debre Berhan, Ethiopia. A total of 350 female students were selected by stratified sampling technique. Self-administered structured questionnaire was used to collect the data. Each independent variable was fitted separately into bivariate logistic analysis and Variables with p-values less than 0.25 in bivariable model were fitted into multivariate logistic regression analysis to evaluate the degree of association with gender-based violence. The significance level was obtained with 95% CI and p-value < 0.05.Result: The prevalence of GBV during the lock down was 124 (36.2%; 95% CI: 0.31, 0.41), and the lifetime prevalence of GBV was 162(47.2%; 95% CI: 0.42, 0.53). The prevalence of life time sexual violence and physical violence were found to be 96 (27.99%; 95% CI: 0.23, 0.33), and 130 (37.99%; 95% CI: 0.33, 0.43), respectively. Sexual violence and physical violence during the lockdown were found to be 73 (21.28), and 61(17.78%), respectively. Respondents educational performance (AOR = 4.52; 95% CI: 1.82,11.3), monthly pocket money received from their parents (AOR = 2.97; 95% CI: 1.56,5.64), free discussion about reproductive issue(AOR = 2.72; 95% CI: 1.42,5.21), and experience of sexual intercourse(AOR = 13.22; 95% CI: 4.80, 36.37) were found to be determinants of gender based violence.Conclusion and recommendation: Gender Based Violence is still a significant sexual and reproductive health issue in Ethiopia. Governmental and non-governmental organizations should give due attention for this problem. Moreover, further large-scale studies are needed to estimate the national figure of GBV and to identify route causes.
Enhanced photocatalytic removal of nitric oxide over Ag-decorated ZnSn(OH)6 microcubes
Authors: Pham Minh-Thuan , Van Nguyen Thi , Nguyen Truc-Mai Thi , Tran Hong-Huy , Nguyen Hieu Trung , Jiang Jheng-Jie , You Sheng-Jie , Wang Ya-Fen 
Published: September 2021

Abstract
Presently, most of the population has been facing a string of severe climate change problems that primarily come from the intensive emission of nitric oxide (NO), which requires a practical approach to sustain our living conditions. Herein, Ag nanoparticles-decorated ZnSn(OH)6 microcubes (Ag:cZHS) photocatalysts were synthesized rapidly and used for photocatalytic NO removal under solar light activation. The properties of the newly prepared photocatalysts are comprehensively characterized by a series of routine methods. The NO removal performance over the ZnSn(OH)6 microcubes (c:ZHS) photocatalysts was increased markedly upon being combined with Ag nanoparticles through the surface plasmon resonance effect. The contribution of e−, h+, •OH, and •O2 was extensively investigated through trapping tests and electron spin resonance analysis (ESR). Also, the by-products and apparent quantum efficiency of the cZHS photocatalysts were studied.
Minimally Invasive Versus Open Surgery for Radical Hysterectomy Followed By Adjuvant Radiotherapy in Intermediate- or High-Risk Early-Stage Cancer of The Cervix: A Retrospective Study
Authors: Zhang Qi-ying , Liu Zi , Wang Ya-li , Zhang Jing , Li Wen , Wang Tao , Wang Juan , Shi Fan , Su Jin 
Published: September 2021

Abstract
Background

Postoperative radiotherapy (RT) or chemoradiotherapy (CRT) improves outcomes of cervical cancer patients with risk factors. Minimally invasive surgery (MIS) has an inferior survival than open radical hysterectomy (ORH), however, the impact of MIS on postoperative RT remains uncertain. The study compared the impacts of MIS versus ORH on delivering of adjuvant RT or CRT for intermediate- or high-risk early-stage cervical cancer.
Methods

Data on stage IB1-IIA2 patients who underwent radical hysterectomy and postoperative RT/CRT in our institution, from 2014 to 2017, were retrospectively collected. Patients with high or intermediate-risk factors who met the Sedlis criteria received postoperative pelvic external beam radiotherapy (50Gy/25f) with platinum-based chemotherapy (0–6 cycles) according to guidelines. Disease-free survival (DFS) and overall survival (OS) were compared in the two surgical groups.
Results

One hundred and twenty-nine patients eligible for the study (68 in ORH; 61 in MIS groups) had similar clinicopathologic features except for the stage (highest in MIS was IB1; IIA1 in ORH) and presence of lymph vascular space invasion (higher in MIS group). The median time interval from surgery to chemotherapy and to RT was shorter in the MIS group. Three-year DFS and OS were similar in both groups. Further sub-analysis indicated that the DFS and OS in intermediate/high-risk groups had no significant difference. Cox-multivariate analyses found that tumor size > 4 cm and time interval from surgery to RT beyond seven weeks were adverse independent prognostic factors for DFS.
Conclusions

In early-stage (IB1-IIA2) cervical cancer patients with intermediate or high-risk factors who received postoperative RT or CRT, no matter they received ORH or MIS as their primary treatment, the DFS and OS had no significant difference, despite TI from surgery to postoperative adjuvant therapy being shorter in the MIS group than ORH.
Antivirus Applied to Jar Malware Detection based on Runtime Behaviors
Authors: Pinheiro Ricardo , Lima Sidney , Souza Danilo , Silva Sthéfano , Lopes Petrônio , Lima Rafael , Oliveira Jemerson , Monteiro Thyago , Fernandes Sérgio , Albuquerque Edison , Silva Washington , Santos Wellington 
Published: September 2021

Abstract
Background and Objective: Java vulnerabilities correspond to 91% of all exploits observed on the World Wide Web. Then, this present work aims to create an antivirus software with machine learning and artificial intelligence, master in Java malwares detection.. Methods: Within the proposed methodology, the suspect Jar sample is executed in order to infect, intentionally, Windows OS monitored in a controlled environment. In all, our antivirus monitors and ponders, statistically, 6,824 actions that the suspected Jar file can do when executed. Results: Our antivirus achieves an average performance of 91.58% in the distinction between benign and malwares Jar files. Different initial conditions, learning functions and architectures of our antivirus are investigated in order to maximize their accuracy.Conclusions: The limitations of commercial antiviruses can be supplied by intelligent antiviruses.Instead of blacklist-based models, our antivirus allows Jar malware detection in a preventive way and not in a reactive manner as Oracle's Java and traditional antivirus modus operandi.
Outcomes of Different Treatments for Hydrosalpinx Undergoing in Vitro Fertilization and Embryo Transfer: A Retrospective Study with a Follow-Up of 5 Years
Authors: Bi Beibei , Han Xiao , Dai Wei , Fang Lanlan , Shi Hao , Hu Linli 
Published: September 2021

Abstract
Background: Except for laparoscopic surgery (salpingectomy or proximal tubal occlusion/ligation), there are also some other common treatments used for hydrosalpinx before IVF such as ultrasonic-guided hydrosalpinx aspiration, hysteroscopic tubal occlusion etc. More evidence is needed to give advice for clinicians on the most effective treatment for hydrosalpinx undergoing IVF-ET.Methods: We reviewed 936 women with hydrosalpinx and 6715 tubal infertile women without hydrosalpinx who underwent IVF/ICSI between January 2014 and August 2019 in our center. Hydrosalpinx patients received different treatments including laparoscopic surgery (only salpingectomy and proximal tubal occlusion/ligation were included), ultrasonic-guided aspiration and hysteroscopic tubal occlusion. Patients received laparoscopic surgery (salpingectomy or proximal tubal occlusion/ligation) before fresh cycles or freeze-thaw embryo transfer cycles. Ultrasonic-guided aspiration was conducted during oocyte retrieval procedure in fresh cycles. Hysteroscopic tubal occlusion was conducted before freeze-thaw embryo transfer cycles. Outcomes were analyzed by One-way ANOVA, Chi-Square test and logistic regression.Results: The live birth rate (LBR) of laparoscopic surgery (salpingectomy or proximal tubal occlusion/ligation) was significantly higher compared with hydrosalpinx aspiration (48.3% vs 39.6%, P=0.024). The cumulative live birth rate (CLBR) of subsequent laparoscopic surgery was significantly higher compared with subsequent hysteroscopic occlusion (65.1% vs 34.1%, P=0.001) and no subsequent treatment (65.1% vs 44.9%, P＜0.005). Subsequent laparoscopic surgery (salpingectomy or proximal tubal occlusion/ligation) significantly improved the CLBR of hydrosalpinx patients who received ultrasonic-guided aspiration and didn't get clinical pregnancy in fresh cycles (Oddis Ratio (OR) =1.875; 95%CI=1.041-3.378, P=0.036).Conclusions: Laparoscopic surgery (salpingectomy or proximal tubal occlusion/ligation) leads to significantly higher LBR than ultrasonic-guided aspiration and significantly higher CLBR than hysteroscopic occlusion and no treatment.
Emodin Ameliorates Acute Pancreatitis-associated Lung Injury Through Inhibiting the Alveolar Macrophages Pyroptosis
Authors: Wu Xiajia , Yao Jiaqi , Hu Qian , Kang Hongxin , Miao Yifan , Zhu Lv , Li Cong , Zhao Xianlin , Li Juan , Wan Meihua , Tang Wenfu 
Published: September 2021

Abstract
Background: Emodin, one of the most dominant components of the traditional Chinese medicine rhubarb, has been utilized to treat acute pancreatitis (AP). Acute lung injury (ALI) is one of the most common complications of acute pancreatitis, leading to a serious mortality rate. However, the specific mechanism of emodin in the treatment of AP-associated lung injury remains unclear. Therefore, we investigated the protective roles of emodin in AP-ALI and its underlying mechanisms in two clinically relevant experimental AP models.Methods: NaT-AP model in rats was constructed using 3.5% sodium taurocholate, and CER+LPS-AP model in mice was constructed using caerulein combined with Lipopolysaccharide. Animals were divided randomly into sham, AP, Ac‐YVAD‐CMK (caspase-1 specific inhibitor, AYC), and emodin groups. AP-associated lung injury was assessed through H&E staining, inflammatory cytokine levels, and myeloperoxidase activity. Alveolar macrophages (AMs) pyroptosis was evaluated by flow cytometry. In bronchoalveolar lavage fluid, the levels of lactate dehydrogenase and inflammatory cytokines were measured by enzyme-linked immunosorbent assay. Pyroptosis-related protein expressions were detected by Western Blot. Results: Emodin, similar to the positive control AYC, significantly alleviated pancreatic and lung damage in rats and mice. Additionally, emodin decreased the pyroptotic rates of AMs, inflammatory cytokines, and the lactate dehydrogenase level. More importantly, the protein expressions of NLRP3, ASC, Caspase1 p10, GSDMD, and GSDMD-NT in AMs were significantly downregulated after emodin intervention. Conclusion: Emodin has a therapeutic effect on AP-associated lung injury, which is at least partially due to the inhibition of NLRP3/Caspase1/GSDMD-mediated AMs pyroptosis signaling ways.
Zhuanggu Guanjie herbal formula mitigates osteoarthritis via NF-κB transduction mechanism in vitro
Authors: Gong Guowei , Zheng Yuzhong , Zhou Xuan , Dai Zhi , Duan Juanhui , Yang Peikui , Liu Xiangzhi , Wen Zhen 
Published: September 2021

Abstract
BackgroundZhuanggu Guanjie herbal formula, a famous Chinese prescription, which is commonly applied for mitigating bone-related problems, clinically. According to the China Pharmacopeia (CP, 2020), this herbal formula includes 12 raw materials, and the major components are Rehmanniae Radix (RR) and Psoraleae Fructus (PF). The anti-osteoarthritis properties of this herbal prescription are well-documented in CP (2020). However, the working mechanism of this ancient herbal formula has not been elucidated. Therefore, we would like to probe the anti-osteoarthritis pharmaceutical values of this ancient herbal prescription.Materials and methodsThe differentiated ATDC5 cells were employed in the following experiments. In the present study, the involvements of cytokine levels and hallmark proteins reflecting inflammatory responses in Zhuanggu Guanjie Capsule (ZGC)-induced differentiated cells were detected by RT-PCR, flow cytometer, western blot and laser confocal assays.ResultsThe cytokines and inflammation-specific proteins, i.e. interleukin (IL)-6, tumor necrosis factor- (TNF-) and inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostaglandin synthesis E2 (PGES-2) were robustly declined after incubating with ZGC for 48 hours, and the attenuation levels were in a dose-dependent manner. Furthermore, ZGC could also block NF-B translocation from cytosol to nucleus and which has been verified by the laser confocal microscope.ConclusionsThe in vitro studies have clarified the anti-osteoarthritis properties of ZGC and the working mechanism involved, and this herbal formula shed light on osteoarthritis treatment.