bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oligo/Amenorrhea Is an Independent Risk Factor Associated With Low Ovarian Response
Authors: Hu Kai-Lun , Gan Kwanghann , Ying Yue , Zheng Junyan , Chen Ruixue , Xue Jinglei , Wu Yiqing , Liu Yifeng , Zhu Yimin , Xing Lanfeng , Zhang Dan 
Published: June 2021

CapsuleOligo/amenorrhea is an independent risk factor of low ovarian response but not high ovarian response, particularly in women with low AMH levels.ObjectiveTo investigate the association of menstrual cycle length (MCL) with anti-Müllerian hormone (AMH) and ovarian response.MethodsThis was a retrospective cohort study. A total of 7471 women who underwent ovarian stimulation and oocyte retrieval were enrolled. The main outcome was the number of oocytes retrieved.Main ResultsA total of 5734 patients were eligible for analysis. In women without polycystic ovary syndrome (PCOS), serum AMH levels and antral follicle count were significantly lower in women with short cycles and higher in women with oligo/amenorrhea than those with a normal menstrual cycle. In women with PCOS, compared to women with a normal menstrual cycle, women with short cycles and women with oligo/amenorrhea showed higher antral follicle count and higher serum AMH levels. Compared with the 0-25th range group of AMH levels, 75-100th percentile groups showed a significantly increased rate of oligo/amenorrhea in women with and without PCOS [adjusted odds ratio (OR) =1.9 (1.04, 3.46), 2.4 (1.70, 3.35)]. In women without PCOS, the low ovarian response was more common in women with short cycles and less common in women with oligo/amenorrhea compared to women with normal cycles [OR=3.0 (2.38, 3.78), 0.7 (0.55, 0.96), respectively]. When adjusted for AMH levels, both short cycles and oligo/amenorrhea were associated with an increased risk of low response [adjusted OR=1.3 (1.02, 1.75), 1.3 (0.93, 1.86), respectively]. In women without PCOS and with low AMH levels, the low ovarian response was more common in women with short cycles as well as in women with oligo/amenorrhea [OR=1.5 (1.08, 1.98), 1.7 (1.08, 2.69), adjusted OR=1.2 (0.86, 1.74), 2.2 (1.31, 3.82), respectively].ConclusionAMH levels are significantly associated with increased risk of oligo/amenorrhea in women with and without PCOS. AMH is an indispensable confounder in the association between MCL and ovarian response in women without PCOS. Oligo/amenorrhea is an independent risk factor associated with a low ovarian response in women without PCOS, particularly those with low AMH levels.
Altered Ex-Vivo Cytokine Responses in Children With Asymptomatic Plasmodium falciparum Infection in Burkina Faso: An Additional Argument to Treat Asymptomatic Malaria?
Authors: Post Annelies , Kaboré Berenger , Berendsen Mike , Diallo Salou , Traore Ousmane , Arts Rob J. W. , Netea Mihai G. , Joosten Leo A. B. , Tinto Halidou , Jacobs Jan , de Mast Quirijn , van der Ven André 
Published: June 2021

IntroductionPatients with clinical malaria have an increased risk for bacterial bloodstream infections. We hypothesized that asymptomatic malaria parasitemia increases susceptibility for bacterial infections through an effect on the innate immune system. We measured circulating cytokine levels and ex-vivo cytokine production capacity in asymptomatic malaria and compared with controls.MethodsData were collected from asymptomatic participants &lt;5 years old with and without positive malaria microscopy, as well as from hospitalized patients &lt;5 years old with clinical malaria, bacteremia, or malaria/bacteremia co-infections in a malaria endemic region of Burkina Faso. Circulating cytokines (TNF-α, IFN-γ, IL-6, IL-10) were measured using multiplex assays. Whole blood from asymptomatic participants with and without positive malaria microscopy were ex-vivo stimulated with S. aureus, E. coli LPS and Salmonella Typhimurium; cytokine concentrations (TNF-α, IFN-γ, IL-1β, IL-6, IL-10) were measured on supernatants using ELISA.ResultsIncluded were children with clinical malaria (n=118), bacteremia (n=22), malaria and bacteremia co-infection (n=9), asymptomatic malaria (n=125), and asymptomatic controls (n=237). Children with either clinical or asymptomatic malaria had higher plasma cytokine concentrations than controls. Cytokine concentrations correlated positively with malaria parasite density with the strongest correlation for IL-10 in both asymptomatic (r=0.63) and clinical malaria (r=0.53). Patients with bacteremia had lower circulating IL-10, TNF-α and IFN-γ and higher IL-6 concentrations, compared to clinical malaria. Ex-vivo whole blood cytokine production to LPS and S. aureus was significantly lower in asymptomatic malaria compared to controls. Whole blood IFN-γ and IL-10 production in response to Salmonella was also lower in asymptomatic malaria.InterpretationIn children with asymptomatic malaria, cytokine responses upon ex-vivo bacterial stimulation are downregulated. Further studies are needed to explore if the suggested impaired innate immune response to bacterial pathogens also translates into impaired control of pathogens such as Salmonella spp.
Cancer Treatment With the Ketogenic Diet: A Systematic Review and Meta-analysis of Animal Studies
Authors: Li Jing , Zhang Haiyan , Dai Zhu 
Published: June 2021

Background: The ketogenic diet (KD) has been reported to play an important role in the development of cancer by an abundance of pre-clinical experiments; however, their conclusions have been controversial. We therefore aimed to perform a systematic review and meta-analysis of animal studies evaluating the effects of KD on cancer.Methods: Relevant studies were collected by searching PubMed, Embase, and Web of Science. Outcome measures comprised tumor weight, tumor volume, and survival time. Meta-analysis was performed using the random-effect model according to heterogeneity.Results: The search resulted in 1,254 references, of which 38 were included in the review and 17 included in the meta-analysis. Pooled results indicated that KD supplementation significantly prolonged survival time [standardized mean difference (SMD) = 1.76, 95% CI (0.58, 2.94), p = 0.003], and reduced tumor weight [SMD = −2.459, 95% CI (−4.188, −0.730), p = 0.027] and tumor volume [SMD = −0.759, 95% CI (−1.349, −0.168), p = 0.012]. Meta-regression and subgroup analysis results suggested that KD supplementation at a ratio of 4:1 was associated with remarkable prolongation of survival time in animals with limited tumor types.Conclusion: In summary, the pre-clinical evidence pointed toward an overall anti-tumor effect of the KD in animals studies currently available with limited tumor types.
Hydrogen Sulfide Attenuated Sepsis-Induced Myocardial Dysfunction Through TLR4 Pathway and Endoplasmic Reticulum Stress
Authors: Chen Yu-hong , Teng Xu , Hu Zhen-jie , Tian Dan-yang , Jin Sheng , Wu Yu-ming 
Published: June 2021

Aims: We examined the change in endogenous hydrogen sulfide (H2S) production and its role in sepsis-induced myocardial dysfunction (SIMD).Results: Significant elevations in plasma cardiac troponin I (cTnI), creatine kinase (CK), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were noted in SIMD patients, whereas left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), and plasma H2S were significantly decreased relative to those in the controls. Plasma H2S was linearly related to LVEF and LVFS. Subsequently, an SIMD model was developed in mice by injecting lipopolysaccharide (LPS), and NaHS, an H2S donor, was used to elucidate the pathophysiological role of H2S. The mice showed decreased ventricular function and increased levels of TNF-α, IL-1β, cTnI, and CK after LPS injections. Toll-like receptor (TLR) 4 protein and endoplasmic reticulum stress (ERS) proteins were over expressed in the SIMD mice. All of the parameters above showed more noticeable variations in cystathionine γ-lyase knockout mice relative to those in wild type mice. The administration of NaHS could improve ventricular function and attenuate inflammation and ERS in the heart.Conclusion: Overall, these findings indicated that endogenous H2S deficiency contributed to SIMD and exogenous H2S ameliorated sepsis-induced myocardial dysfunction by suppressing inflammation and ERS via inhibition of the TLR4 pathway.
Sleep Quality in Medical Staffs During the Outbreak of Coronavirus Disease 2019 in China: A Web-Based Cross-Sectional Study
Authors: Jiang Furong , Xiao Yi , Dong Huixi , Liu Siyu , Guo Feng , Gong Zhicheng , Xiao Shuiyuan , Shen Minxue , Zhou Qiuhong , Li Jianling 
Published: June 2021

Background: The aim of this study was to describe the sleep quality and its influencing factors among medical workers of different working statuses and staff types during the coronavirus disease 2019 (COVID-19) epidemic.Methods: Through an online questionnaire survey, all medical staffs in Xiangya Hospital were invited to complete sections on general information, the Self-Rating Scale of Sleep (SRSS), the Depression, Anxiety and Stress Scale (DASS-21), the Social Support Rating Scale (SSRS), and the Simplified Coping Style Questionnaire (CSQ).Results: A total of 4,245 respondents completed the survey. Among them, 38.7% had sleep disturbance. After matching, the SRSS scores in the staffs who were assigned to the intensive care unit (ICU) of Union Hospital in Wuhan and working in the epidemic area of Xiangya Hospital were not significantly different (P &gt; 0.05); the SRSS scores in the battlefront staffs were significantly higher than (P &lt; 0.05) those who were not treating patients infected with COVID-19. The SRSS scores of nurses were significantly higher than those of doctors and hospital administrators (P &lt; 0.01). Anxiety, depression, and coping style were associated with sleep disturbance.Conclusion: The sleep quality of the medical staffs has been impaired during the epidemic period, especially among nurses, doctors, and administrators who are working on the front line. Medical institutions should strengthen psychological services and coping strategies for medical staffs.
Quality of Life and Mental Health in Kidney Transplant Recipients During the COVID-19 Pandemic
Authors: De Pasquale Concetta , Pistorio Maria Luisa , Veroux Pierfrancesco , Gioco Rossella , Giaquinta Alessia , Privitera Francesca , Veroux Massimiliano 
Published: June 2021

Introduction: The COVID-19 pandemic has led to an increase in mental distress such as phobic anxieties, depressive reactions, hypochondriac concerns, and insomnia. Among the causes are risk of infection and prolonged isolation. This study aimed to analyze psychopathological variables and dysfunctional lifestyles related to adequate therapeutic compliance in kidney transplant recipients.Methods: Eighty-nine kidney transplant recipients were evaluated using an online protocol including a questionnaire concerning habits, lifestyle and psychophysical well-being in the COVID-19 period, the Middlesex Hospital Questionnaire (MHQ) and the SF-36 Health Survey to evaluate the perception of their physical and emotional health.Results: Of these recipients, 28.6% reported changes in their emotional state. Sleep quality deteriorated for 16.1%. Anxiety (M = 5.57, r = 0.33; p &lt; 0.05) and phobia (M = 6.28, r = 0.26; p &lt; 0.05) correlated with concerns related to physical health. There was no negative impact on relational and socialization aspects, which were likely well compensated by the use of remote technologies such as video phone calls, Zoom meetings and use of computers (r = 0.99; r = 0.80; p &lt; 0.05).Conclusions: It would be interesting to maintain this remote visit and interview mode to monitor, on a clinical and psychological level, kidney transplant recipients in subsequent follow-ups (12–18 months), to check for any psychopathological disorders and/or changes in their resilience capacity in the Coronavirus emergency.
DETERMINAN PERNIKAHAN USIA MUDA DI KABUPATEN POLEWALI MANDAR
Authors: Raehan Raehan , Sitti Aras Diana  , Wahida Munir  
Published: June 2021

Indonesia merupakan negara berkembang yang termasuk negara dengan persentase pernikahan usia dini tinggi di dunia. Pernikahan dini pada remaja merupakan salah satu masalah kesehatan reproduksi remaja dan memiliki lebih banyak implikasi negatif terhadap kelangsungan hidup remaja. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan kejadian pernikahan usia muda di Kabupaten Polewali Mandar tahun 2019. Dengan menggunakan desain penelitian cross sectional dengan pendekatan kuantitatif. Hasil penelitian menunjukkan ada pengaruh yang signifikan antara pengetahuan responden terhadap kejadian pernikahan Usia Muda. Ada pengaruh antara pendidikan, pengetahuan, ekonomi responden terhadap kejadian pernikahan dini. Diharapakan untuk lebih meningkatkan penidikan kesehatan bagi remaja dan orang tuanya tentang bahanyanya melakukan pernikahan dini bagi kesehatan maupun masa depan bagi remaja itu sendiri.
PERILAKU IBU DALAM STIMULASI TUMBUH KEMBANG BALITA USIA 0-6 BULAN SETELAH PEMBERIAN ANTICIPATORY GUIDANCE
Authors: Trianita Desi , Wilujeng Atik Pramesti , Indriyani Ninis 
Published: June 2021

Periode balita adalah periode tumbuh kembang yang pesat dimana anak mencapai perkembangan yang optimal pada usia ini. Keluarga terutama ibu adalah pihak yang memiliki peran penting dalam mengoptimalkan tumbuh kembang anak. Penelitian ini bertujuan menganalisis perbedaan perilaku ibu dalam memberikan stimulasi tumbuh kembang setelah diberikan anticipatory guidance dengan kelompok ibu yang tidak diberikan anticipatory guidance. Desain penelitian ini menggunakan quasy experimental post test only non equivalent control group sedangkan sampelnya adalah ibu-ibu yang memiliki bayi usia 0-6 bulan sebanyak 54 orang yang diambil dengan tehnik purposive sampling. Hasil uji statistik U Mann-Whitney menunjukkan bahwa terdapat perbedaan perilaku ibu dalam memberikan stimulasi tumbuh kembang pada kelompok perlakuan dengan kelompok kontrol dengan nilai ρ = 0,000. Penilaian perilaku ibu dalam memberikan stimulasi tumbuh kembang dilakukan dengan melakukan pengisian kuesioner Anticipatory guidance merupakan pemberian bimbingan dan pendampingan oleh tenaga kesehatan kepada orang tua anak dalam hal ini adalah ibu mengenai bagaimana mengasuh dan memenuhi kebutuhan tumbuh kembang anaknya.
A DÖNTÉS HÁTTERÉBEN ÁLLÓ KOGNITÍV KÉPESSÉGEK ÉS STRESSZ TOLERANCIA SZINTJÉNEK ÖSSZEHASONLÍTÓ ELEMZÉSE KEZDŐ ÉS TAPASZTALT SPORTOLÓKNÁL
Authors: Donka Dorottya Bianka , Balogh László 
Published: June 2021

Bevezetés: Kiemelten fontos a csapatjátékokban, a kognitív képességek az érzékelés, észlelés, döntés (taktikai gondolkodás, tanulás, figyelem, gondolkodás, érzelmek) stressz tolerancia, sőt az ezek hátterében álló, a végrehajtás minőségét befolyásoló, motorikus képességek, technikai-taktikai képzettség szintje.
Célkitűzés: A játékintelligencia és stressz tűrőképesség vizsgálata során azt tapasztaltuk, hogy a kezdő/ fiatal és tapasztalt csapatsportolók stressz tűrőképességében van különbség (BALOGH, DONKA 2020). Az eredményeink azt mutatták, hogy a tapasztalt sportolóknak jobb a stressz tűrő képességük, azonban mivel ez egy leíró tanulmány volt, ezt az állításunkat szerettük volna nagyobb alanyszámmal is elvégezni, kognitív képességek vizsgálatának bevonásával is.Módszer: A kutatásunk módszere kísérlet. Keresztmetszeti vizsgálatot végeztünk 41 férfi és 13 nő csapatsportolón. Kognitív képességekre a VTS DT programcsomagját, stressz mérésre az MDE Heidelberg Stressz Holterét (gasztro, HR, TH, GSR) használtuk. A 35 perces mérés során az első szakaszban nyugalmi állapotot, a második szakaszban egy 10 perces stresszhelyzetre (kognitív tesztre VTS-DT) való reakciót, a harmadik szakaszban pedig egy megnyugvási állapotot, latenciát mértünk.Eredmények: Szignifikáns eredményeket kaptunk, miszerint valóban van kapcsolat a nők és férfiak stressz tűrő és kognitív képessége között. A sportágak összehasonlítása során is szignifikáns eredményeket kaptunk, hiszen a futballisták minden más csapathoz képest rosszabban tűrték a stresszt, és többet hibáztak a VTS-DT teszt során.Következtetések: A jövőben a kezdő és tapasztalt kategóriába való besorolást egységesebben szükséges végezni, valamint a sportágak szerinti egyenlőtlen alanyszámú részvétel sem kedvező. Azonban bíztató, hogy a szignifikáns eredményeknél egyértelmű kapcsolat mutatható ki a stressz tűrőképesség és a jó döntések száma között. Ezek az eredmények további kutatási területeket tárnak fel számunkra.
A TÁNC- ÉS MOZGÁSTERÁPIÁK SZEREPE A STRESSZKEZELÉSBEN
Authors: Barna Lilla , Balogh László 
Published: June 2021

Napjainkban kedvelt kutatási téma az egészség és a fizikai aktivitás kapcsolata. Számtalan egészség megőrzési program segít elérni az egyén számára a fizikai aktivitás adta gyakorlási lehetőséget. Számos cikk írja le a fizikai aktivitás, ám valamivel kevesebb a tánc- és mozgásterápiák pozitív hatását a stressz kezeléssel kapcsolatban mind a gyermekek, fiatal felnőttek, középkorúak, illetve idősek, azon belül nők és férfiak számára egyaránt.
Az analízishez angol és magyar nyelvű vizsgálatok, szisztematikus tanulmányok áttekintését alkalmaztuk a stressz, a tánc- és mozgásterápiák kapcsolatának elemzésére a PubMed, a Google Scholar, a Cochrane Library, a ScienceDirect és a Reserch Gate adatbázisokból.
Napjaink egyik legnagyobb problémája a hétköznapokban megjelenő stressz annak kezeletlensége és egészségkárosító tulajdonságai. Így számos szakirodalomban számolnak be arról, hogy a tánc, mint fizikai aktivitás művelésével pozitív változás érhető el az egyensúlyi állapotból (homeosztázis) történő kibillenés és az arra történő reakció területén. Vizsgálatok bizonyítják, hogy a táncos mozgásprogramok (akár egyedül, párban, vagy csoportban) kisebb vagy nagyobb részt segítik a stressz kezelést és stresszre megjelenő reakciók feldolgozását.
Bizonyított, hogy a fizikai aktivitás hatására a stressz megjelenése és feldolgozása könnyebben kezelhető lesz. A tánc által az egyén kibillen a komfortzónájából számos koordinációs képességét és kognitív funkcióját aktivizálva, így kihasználva a mozgás és a zene adta pozitív következményeket, hatással lehet például a szorongás, a depresszió, az elszigetelődéssel járó megbetegedések kezelésében. Hiszen a tánc által rengeteg változás zajlik le mind a testben, mind az agyban, ezáltal boldogabbnak, kiegyensúlyozottabbnak érezheti magát az egyén, így életminősége, még ha csak a eleinte a mozgás időtartama alatt is, de pozitívan alakul.
Conduct Unbecoming? Teacher Professionalism, Ethical Codes, and Shifting Social Expectations
Authors: Cochran Natasha , Lemisko Lynn 
Published: June 2021

In this paper, we share findings from a historical investigation into changing expectations regarding teacher conduct as connected to the evolving Saskatchewan Teachers’ Federation Code of Ethics and the eventual proclamation of a Government-mandated teacher regulatory board. This study was based on the idea that views of appropriate conduct embedded in ethical codes evolve in relation to shifting societal norms and values. We demonstrate that the tone and content of ethical codes of conduct for Saskatchewan teachers transformed from explicit and concrete to abstract and ambiguous.
Keywords: conduct unbecoming; code of ethics; teacher regulation; teaching profession
Curriculum Integration and the Forgotten Indigenous Students: Reflecting on Métis Teachers’ Experience
Authors: Gillies Carmen Leigh 
Published: June 2021

Curriculum integration, or in other words, changing what students are taught within racially desegregated Canadian schools, has served as a primary but incomplete pathway to racial justice. In this paper, I present evidence from a qualitative critical race theory (CRT) methodological study with 13 Métis teachers to demonstrate how curricular integration has been framed as a key solution to inequitable outcomes concerning Indigenous students. This strategy has been instilled within the Saskatchewan K–12 education system by a wide spectrum of authorities over several decades. Although absolutely essential for multiple reasons, I argue that teaching students about Indigenous knowledge systems and experiences, as well as anti-racist content, cannot resolve the systemic racial injustices encountered by Indigenous students who attend provincial schools. In particular, three CRT analytical tools—structural determinism, anti-essentialism, and interest convergence—are utilized to examine the limitations of curricular integration as a strategy of racial justice.
Keywords: Métis teachers; Indigenous education; critical race theory; integrated schools
Formulation and Evaluation of Benidipine Nano-suspension by Precipitation Method using Central Composite Design
Authors: Patel Sejal , Patel Anita P 
Published: June 2021

In the interest of administration of dosage form oral route is most desirable and preferred method. Poor solubility and slow dissolution rate major challenges in upcoming and existing therapeutically active compound. Water insoluble drug indicate insufficient bioavailability as well dissolution resulting in fluctuating plasma level. Benidipine (BND) is Biopharmaceutical Classification System Class-II drug having low solubility and high permeability, antihypertensive drug has lower bioavailability. The purpose of the present study was to improve solubility as well dissolution profile of Benidipine HCL. BND nanosuspension was formulated using precipitation technique. Various polymers were evaluated viz. HPMC E15, Tween 20, PVP K30 in preliminary trial to stabilized nanosuspension but PVP K30 was selected among them. The solubility of BND was carried out using different solvents like Ethanol, Acetonitrile; Acetone. Ethanol was used as a preferred solvent as BND shows high solubility in it. The effect of different important process parameters e.g. selection of polymer concentration X1(10 mg), solvent concentration X2 (0.2 ml) were investigated by Central Composite factorial design to accomplish desired particle size and rate of dissolution. Stirring speed and time of stirring was kept constant as 1000 rpm and 2h respectively. To achieve optimized batch, 9 formulations (F1-F9) were prepared. The optimized batch had 237 nm particle size Y1, and showed in-vitro dissolution Y2 98±0.72 % in 30 mins related to pure BND (58±0.25%) and zeta potential was -15.3. None of interaction between drug and polymer was confirmed by Differential scanning calorimetry (DSC) and FT-IR analysis. The obtained results showed that issues related particle size (nm) and rate of dissolution of BND has been solved when nanosuspension can be prepared by precipitation method by considering optimized parameter due to formation of nanosized particles
Le requiem des abscons : des effets pervers de l’usage extrême du principe de précaution
Authors: Baumard Philippe 
Published: June 2021

La présente contribution explore les biais de perception sélective qui ont siégé dans la gestion de la crise pandémique du Sars-CoV-2 lors de sa première phase de croissance, puis de décroissance (oct. 2019-sept. 2020). En mobilisant les cadres théoriques de l’apprentissage stratégique (proposés par des auteurs tels que Cyert, March, Simon, Starbuck), nous examinons les erreurs stratégiques de gestion de la crise, en particulier la confiance excessive donnée à des modèles épidémiologiques dont les conditions de production scientifique sont ici discutées. L’article se conclut sur une réflexion sur la capacité humaine à générer des vides stratégiques pour ensuite s’y fondre, échouant à apprendre des expériences passées aussi bien que de la très présente réalité.