bluuebunny/crossref_metadata_2025_split huggingface dataset:
Getting Ready for Beyond-5G, Super-IoT and 6G at Hardware Passive Components Level – A Multi-State RF-MEMS Monolithic Step Attenuator Analyzed up to 60 GHz
Authors: Iannacci Jacopo , Tagliapietra Girolamo 
Published: November 2021

Abstract
Looking at 2030, the landscape of technology will be dominated by paradigms like 6G, Super-IoT (Internet of Things) and Tactile Internet (TI). From the perspective of Hardware (HW) components technologies, the turning into reality of such scenarios will demand for a radical reconceptualization of devices, sub-systems and systems, probably modifying the concept of HW itself. Driven by the target of taking initial steps in the direction of such future applications, this work discusses a 4 bit RF power step attenuator entirely realized in RF-MEMS technology. Physical samples are fabricated in a surface micromachining technology and rely on electrostatically actuated cantilevered MEMS ohmic switches to select or short resistive loads placed along the RF line. Fabricated devices are tested and validated up to 30 GHz, while simulations are discussed up to 60 GHz for the full set of allowed configurations. Despite a few technology non-idealities, the network shows levels of attenuation with a flatness as good as 1 dB over 60 GHz frequency span. The measured and simulated data reported in this work offer important indications on how to improve the network concept, both at technology and design level.
Model Simulations Unveil The Structure-Function-Dynamics Relationship of The Cerebellar Cortical Microcircuit
Authors: De Schepper Robin , Geminiani Alice , Masoli Stefano , Rizza Martina Francesca , Antonietti Alberto , Casellato Claudia , D'Angelo Egidio 
Published: November 2021

Abstract
The cerebellar network is renowned for its regular architecture that has inspired foundational computational theories. However, the relationship between circuit structure, function and dynamics remained elusive. To tackle the issue, we have developed an advanced computational modeling framework that allowed us to reconstruct and simulate the structure and function of the mouse cerebellar cortex using morphologically realistic multi-compartmental neuron models. The cerebellar connectome was generated through appropriate connection rules, unifying a collection of scattered experimental data into a coherent construct and providing a new model-based ground-truth about circuit organization. Naturalistic background and sensory-burst stimulation were then used for functional validation against recordings in vivo, monitoring the impact of cellular mechanisms on signal propagation and spatio-temporal processing. Our simulations show, for the first time, how mossy fibers entrain the local neuronal microcircuit boosting the formation of columns of activity travelling from the granular to the molecular layer providing a new resource for the investigation of cerebellar computation.
A GC-MS-based Metabolomic Strategy to Investigate the Protective Effects of Mulberry Polysaccharide on CCl4-induced Acute Liver Injury in Mice
Authors: Ma Xiaofen , Yang Jian , Baker Subinur , Li Zhen , Li Xin , Li Fei , ma xiaoli 
Published: November 2021

Abstract
BackgroundMulberry (Morus alba) fruits of the woody mulberry tree (family: Moraceae Morus) is a type of mulberry fruit grown in the southern Xinjiang region,which polysaccharides have antioxidant and liver protective effects.This article further preliminary study on the protective effects of mulberry polysaccharide (MP) on liver.MethodsA detection kit was used to assess serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver malondialdehyde (MDA), superoxide dismutase (SOD) and other indicators. Liver tissue sections were stained with hematoxylin and eosin (H&E) and observed under a microscope. The entire endogenous metabolite proﬁling was acquired via metabolomics strategy using gas chromatography-mass spectrometry (GC-MS) to assess the underlying protective mechanisms of MPs. ResultsResults indicated that MPs exerted a hepatoprotective effect on acute liver injury by decreasing serum ALT and AST levels, hepatic MDA, and restored hepatic SOD glutathione peroxidase (GSH-Px) activities. A total of 33 possible endogenous metabolites associated with lipid, glucose, and energy metabolism including amino acids, sugars, and fatty acids, were found.Conclusions﻿The results of the present study provide a reference for elucidating the protective mechanisms of MPs against acute liver injury.
Endogenous Calcium Mediated The Seedling Growth And Fluoride Stress Tolerance In Four Bean Genotypes
Authors: Chahine Sara , Melito Sara , Giannini Vittoria , Roggero Pier Paolo , Seddaiu Giovanna 
Published: November 2021

Abstract
Fluoride (F) pollution is a global environmental problem representing a severe risk for food and vegetables grown in contaminated soils. Phaseolus vulgaris L. is widely cultivated in arid and semi-arid regions and in F contaminated areas of the world. F tolerance during germination and seedling growth was evaluated for four bean ecotypes: Borlotto nano and three African genotypes (Lyamungu 85, Lyamungu 90 and Jesca).Seeds were grown in sand enriched with NaF or KF at three different levels (0, 80 and 200 mg kg-1). NaCl was used as a benchmark to determine a potential effect of different Na levels in plant. Total F content and minerals accumulation (Na, K and Ca) in roots and shoots were measured. The translocation factor, growth ratio, F tolerance index were evaluated to estimate plant-salt response. Germination rate decreased with increased F level. Borlotto was more F sensitive (0% germination with 200 mg kg-1of KF and NaF) than African genotypes. Under the highest F concentration (200 mg kg-1), F preferentially accumulated in shoots (Jesca 75.7 mg kg-1, Lyamungu 85 100.1 mg kg-1 and Lyamungu 90 115.4 mg kg-1). Ca content in roots was negatively correlated to F absorption, suggesting its antagonistic role to F mobility.Based on these parameters, Jesca and Lyamungu 85 were the most tolerant species recording a low F uptake and a high Ca content in the root. This study highlighted the central role of Ca, as a key secondary messenger in regulating the plant growth and development under F stress.
Upregulated CCNE1 Correlates with Poor Prognosis, Tumor Immune Infiltration and Escape in Breast Cancer
Authors: Feng Jiaxi , Hu Yanan , Liu Dan , Wang Shanshan , Zhang Mengci , Wang Yan , Qiu Shipei , Li Xiang , Li Xinping 
Published: November 2021

Abstract
BackgroundBreast cancer (BC) is the most common malignant tumor in women and widely known for its poor prognosis. More and more research has discovered that cyclin E1 (CCNE1) plays an important role in progression of various types of cancer. But its specific mechanism in BC progression still needs further research to explore.MethodsAt first, we determined the expression and prognostic value of CCNE1 through The Cancer Genome Atlas (TCGA) database and The Genotype-Tissue Expression (GTEx) data. Then, we predicted the upstream non-coding RNAs of CCNE1 through StarBase, GEPIA, and Kaplan-Meier plotter database. We further studied the correlation of CCNE1 expression with BC immune cell infiltration, biomarkers of immune cells and immune checkpoints expression through TIMER and GEPIA databases.ResultsThe results suggested that CCNE1 was significantly upregulated in BC and its high expression was correlated with poor prognosis in BC patients. Next, we identified long noncoding RNA (lncRNA) LINC00511 / microRNA-195-5p (miR-195-5p) / CCNE1 axis as the most potential pathway that could regulate CCNE1 expression in BC through StarBase, GEPIA, and Kaplan-Meier plotter database. Furthermore, our in-depth research discovered that CCNE1 expression level was significantly correlated with tumor immune cell inﬁltration, biomarkers of immune cells, and immune checkpoint expression in BC.ConclusionIn summary, high expression level of CCNE1 was significantly correlated with poor prognosis, tumor immune infiltration and escape in BC.
Earthworm Community In Relation To Soil Properties And Metals In Hebei Province, North China
Authors: Yin Yue , Wang Kun , Chen Miaomiao , Mu Xiaoquan , Li Bo , Yang Yang , Wang Dianwu 
Published: November 2021

Abstract
In this study, we examined the influence of soil properties (pH, total potassium (TK), available potassium (AK), total nitrogen (TN), total phosphorus (TP), available potassium (AP), cation exchange capacity (CEC), and soil organic carbon (SOC)), and metals (Cd, Pb, Cu, and Zn) on the density, diversity, and species composition of earthworms in the Hebei Province, North China. In total, 535 earthworms were collected from 20 sites in the study area, and belonged to three families, six genera, and ten species. Amynthas hupeiensis (39.4%) and Drawida gisti (37.8%) were the dominant species. The correlations between soil variables and earthworm composition determined using redundancy analysis indicated that SOC, TK, and AK enhanced earthworm density (total, adult, and juvenile) and species (A. hupeiensis and D. gisti) abundances. Earthworm composition remained unaffected by the metals (Cd and Pb) in the uncontaminated sites; in contrast, species were absent in areas with high metal concentrations (S19 and S20). Soil TN content was negatively and positively related to Shannon and Peilou indexes (p<0.05), respectively, indicating that TN may be pivotal in influencing earthworm diversity and species evenness. Overall, the soil properties such as K, SOC, and TN were the key variables affecting earthworm density, diversity, and species dominance.
Preparation of a Novel Clay Loaded With Fe (VI) for Degradation of Cefazolin: Performance, Pathway and Mechanism
Authors: Zhou Mingluo , Zhou Riyu , Jiang Peng , Liang Huili , Zhou Yi , Chen Haiyan , Wang Bin , Chen Shu , Tu Weiguo , Yang Yuankun 
Published: November 2021

Abstract
Cephalosporin antibiotics, a group of widely prescribed antibiotics, are frequently detected in wastewater effluent and in the natural aquatic environment. Materials have been sought to effectively degrade the antibiotics. In this study, a novel high-iron clay was prepared with potassium ferrate and montmorillonite via a strong alkaline in-situ synthesis method. Degradation of cefazolin sodium (CFZ) by this novel Fe (VI)-clay was investigated. The optimal conditions for the degradation of CFZ were determined using a single factor experiment and response surface optimization method. We found that 89.84 % removal efficiency was obtained in 137 min when pH value was 5.16 and Fe (VI)-clay dosage was 0.79 g/100mL. The CFZ degradation mechanism was studied by the Density Functional Theory (DFT) in combination with spectroscopic and mass spectroscopic analysis. The spectroscopic characteristics of the products at different stages showed that the oxidation decomposition reaction occurred during the degradation of CFZ by Fe(VI) -clay. Further, DFT calculation combined with GC-MS results showed that the degradation pathways of CFZ by the Fe (VI)-clay was mainly the cleavage of β-lactam, thiadiazole, tetrazole and dihydrothiazine rings.
Efficacy of a Chinese Herbal Medicine, Qinzhuliangxue Granules, for The Treatment of Eczema: A Randomized, Double-Blind, Multi-Center Clinical Trial
Authors: Wang Ruiping , Zheng Qi , Chen Yu , Li Su , Jiang Wencheng , Yin Qingfeng , Cai Xi , Mao Weian , Li Yongmei , Zhang Huimin , Xie Shaoqiong , Yang Qinping , Li Fulun , Li Xin , Li Bin 
Published: November 2021

Abstract
Background: Eczema is the most common allergic skin disorder in the world. The treatment of eczema with western medicine generally involves antihistamines, antibiotics, glucocorticoids, and immunomodulatory preparations, which are limited by common relapse events following drug withdrawal. Many traditional Chinese medicines have demonstrated significant effects on eczema; however, high-quality clinical studies are lacking.Objectives: We performed a multi-center, randomized, double-blind, clinical trial to evaluate the efficacy and safety of a Chinese herbal medicine, Qinzhuliangxue (QZLX) granules, and its effect on recurrence of eczema.Methods: A total of 342 patients with eczema who met the inclusion criteria were recruited and randomly divided into a traditional Chinese medicine (TCM) treatment group, a Western medicine (WM) treatment group, and a TCM plus WM treatment group, according to random numbers generated using the central stratified zone group random method. The Eczema Area and Severity Index (EASI) score and the level of pruritus were set as the primary outcome measures, and the Dermatology Quality of Life Index (DLQI) score served as the secondary outcome measure. In this study, a two-sided p-value less than 0.05 was considered statistically significant. Results: The median EASI score and the pruritus level at baseline were not statistically significant. However, as the treatment period progressed, the EASI score (including the total score and scores for the head, upper limb, trunk, and lower limb) and pruritus level decreased significantly in all three treatment groups. Repeated measures Analysis of Variance (ANOVA) demonstrated that the DLQI scores in the TCM, WM, and TCM+WM groups decreased significantly over time. Limitations: Basic experiments need to be increased.Conclusions: The Chinese herbal medicine QZLX granules significantly improved the EASI score and decreased the pruritus level in eczema patients, with good safety and no obvious adverse reactions.Trial RegistrationThe protocol for this study was registered with the Clinical Trials database (NCT02517957). Registered 1 May 2015, Xia Shi Surgical Treatment for Eczema Multi-center Clinical Research - Full Text View - ClinicalTrials.gov
A Spiking Visual Neuron for Depth Perceptual Systems
Authors: Chen Chunsheng , He Yongli , Mao Huiwu , Zhu Li , Wang Xiangjing , Zhu Ying , Zhu Yixin , Shi Yi , Wan Changjin , Wan Qing 
Published: November 2021

Abstract
The biological visual system encodes information into spikes and processes them parallelly by the neural network, which enables the perception with high throughput of visual information processing at an energy budget of a few watts. The parallelism and efficiency of bio-visual system motivates electronic implementation of this biological computing paradigm, which is challenged by the lack of bionic devices, such as spiking neurons that can mimic its biological counterpart. Here, we present a highly bio-realistic spiking visual neuron based on an Ag/TaOX/ITO memristor. Such spiking visual neuron collects visual information by a photodetector, encodes them into action potentials through the memristive spiking encoder, and interprets them for recognition tasks based on a network of neuromorphic transistors. The firing spikes generated by the memristive spiking encoders have a frequency range of 1-200 Hz and sub-micro watts power consumption, very close to the biological counterparts. Furthermore, a spiking visual system is demonstrated, replicating the distance-dependent response and eye fatigue of biological visual systems. The mimicked depth perception shows a recognition improvement by adapting to sights at different distance. Our design presents a fundamental building block for energy-efficient and biologically plausible artificial visual systems.
Wide-range IR spectra of diarylethene derivatives and their simulation using the Density Functional Theory
Authors: Jarota Arkadiusz , Drwal Daria , Pięta Jakub , Pastorczak Ewa 
Published: November 2021

Abstract
Diarylethenes (DAEs), promising photochromic molecular switches, undergo pericyclic reactions upon ultraviolet or visible light illumination. For this reason, most studies on DAEs employ UV-vis spectroscopies. However, also their infrared (IR) spectra are valuable in particular, for understanding the vibrational dynamics which accompanies the relevant photoreactions. An accurate assignment of IR bands to molecular modes can be achieved through a comparison between experimental and computed theoretical spectra. Even though more sophisticated computational methods are available, the density functional theory (DFT) is usually employed for this task, because of its modest cost and versatility. Here, we have tested the ability of several DFT functionals to reproduce the wide-range, 400-3200 cm−1, IR spectra of open and closed isomers of four representative DAE molecules. We find that global and range-separated, corrected for anharmonicity by scaling factors, hybrid DFT functionals are able to reproduce the IR spectra of DAEs accurately, especially in the low-frequency and fingerprint ranges. Instead of the most commonly used B3LYP functional, we recommend the use of dispersion-corrected PBE0 functional, which at the same cost as B3LYP, offers a more accurate and reliable performance, with a mean absolute error of just under 10 cm−1 and a mean signed error of 0.2 cm −1.
ANALISIS PEMBERDAYAAN UMKM PADA MASA PANDEMI COVID-19
Authors: Emiliani Fristica , Rizqiana Sabilla , Suhandito Ryan , Muchibbah Navira Nuraini , Nurmahfidhoh Risna , Habib Muhammad Alhada Fuadilah 
Published: November 2021

Abstrak: UMKM (Usaha Mikro Kecil dan Menengah) merupakan usaha (bisnis) yang umumnya dilakukan oleh masyarakat dalam skala rumah tangga. UMKM di Indonesia memiliki andil yang cukup besar dalam meningkatkan perekonomian masyarakat, karena UMKM dapat membantu Indonesia ketika mengalami krisis ekonomi tahun 1998. Pandemi covid-19 yang dimulai dari tahun 2020 hingga 2021 ini, menjadi penyebab UMKM di berbagai daerah mengalami penurunan pendapatan. Pada masa pandemi covid-19 beberapa pengusaha UMKM yang mengalami penurunan penghasilan antara lain seperti pelaku bisnis pariwisata, transportasi atau pun kuliner. Pelaku UMKM pada masa pandemi covid-19 dapat memaksimalkan penjualannya menggunakan media online dan para pelanggan dapat menilai produk yang dibeli dengan cara memberikan bintang untuk meningkatkan penjualan agar dikenal masyarakat secara luas. Penelitian ini menggunakan metode penelitian deskriptif kualitatif dengan teknik pengumpulan data studi kepustakaan. Adapun hasil penelitian ini menunjukkan bahwa strategi pemberdayaan masyarakat melalui UMKM yang tepat pada masa pandemi yaitu dengan mengembangkan produk melalui e-commerce, mempromosikan produk dengan pemasaran digital, mempertahankan Customer Relationship Marketing (CRM), dan memperbaiki kualitas dan pelayanan produk maupun jasa.
Kata Kunci: Pemberdayaan UMKM; Pandemi Covid-19; UMKM Pada Masa Pandemi.

Abstract: MSME (Micro, Small and Medium Enterprises) are businesses (businesses) that are generally carried out by the community on a household scale. MSME in Indonesia have a significant role in improving the community's economy, because MSME can help Indonesia when it experienced the economic crisis in 1998. The COVID-19 pandemic, which started from 2020 to 2021, has caused MSME in various regions to experience a decline in income. During the COVID-19 pandemic, several MSME entrepreneurs experienced a decline in their income, such as tourism, transportation or culinary businesses. MSME actors during the COVID-19 pandemic can maximize their sales using online media and customers can assess the products purchased by giving stars to increase sales so that they are widely known to the public. This study uses descriptive qualitative research methods with data collection techniques literature study. The results of this study indicate that the right strategy for community empowerment through MSME during the pandemic is to develop products through e-commerce, promote products with digital marketing, maintain Customer Relationship Marketing (CRM), and improve the quality and service of products and services.
Keywords: MSME Empowerment; Covid-19 Pandemic; MSMEs During a Pandemic.
TRAUMA PASCA TSUNAMI DALAM NOVEL TE O TORIATTE KARYA AKMAL NASERY BASRAL: PENDEKATAN PSIKOANALISIS
Authors: Widiastuti Rini 
Published: October 2021

Tsunami Aceh merupakan bencana yang meluluhlantakan wilayah sekitar pesisir pantai, ratusan ribu orang meninggal dan hilang, harta benda tak bersisa. Bencana Tsunami menyisakan trauma yang mendalam pada tokoh Meutia yang diceritakan dalam novel Te O Toriatte karya Akmal Nasery Basral. Tulisan ini mengungkapkan bagaimana Meutia menjalani hidup pascatsunami dengan trauma yang dideritanya melalui pendekatan psikoanalisis dengan menggunakan metode deskriptif. Hasil analisis menunjukkan bahwa Meutia mengalami trauma dan sering berhalusinasi setelah menghadapi peristiwa tsunami Aceh, Jepang, dan kebocoran reaktor nuklir di Jepang. Meutia juga menderita kepribadian ganda.
PERPINDAHAN PEMUKIMAN PENDUKUNG SITUS DAS SEKAMPUNG: JEJAK BENCANA MASA LAMPAU
Authors: Laili Nurul 
Published: October 2021

Way Sekampung sebagai sungai utama mempunyai peranan tumbuhnya peradaban manusia, dari masa lampau hingga kini. Jejak arkeologi menunjukkan adanya tumbuhnya peradaban masa lampau dengan hadirnya situs-situs arkeologi di sepanjang Daerah Aliran Sungai (DAS) Sekampung. Tulisan ini fokus pada tiga situs yang berada di DAS Sekampung Lampung Timur, yaitu Situs Serampang, Cicilik, dan Putak. Pendekatan yang digunakan dalam tulisan ini adalah pendekatan atas tinggalan materi dan memori kolektif dengan melalui wawancara. Hasil penelitian menunjukkan ketiga situs tersebut saling terkait dan dimungkinkan telah terjadi perpindahan hunian yang diakibatkan adanya bencana sosial berupa teror dan serangan bajau (bajak laut).
LEKSIKON-LEKSIKON DARI SARS-COV SAMPAI DENGAN COVID-19 SEBAGAI PENANDA SUATU PERISTIWA SEJARAH
Authors: Sariah  
Published: October 2021

Setiap peristiwa melahirkan leksikon atau diksi yang menjadi indikator utama dalam peristiwa sejarah, misal wabah cacar melahirkan varian istilah dari penyakit tersebut, seperti cacar, cacar air, cacar api, cacar alas, dan sebagainya. Masa pandemi Covid-19 juga melahirkan leksikon yang menjadi karakteristik masa pandemi Covid-19. Pandemi ini dengan segala persoalannya melahirkan leksikon yang menarik untuk disimak. Tulisan ini mengangkat leksikon masa pandemi Covid-19. Masalah yang menjadi fokus tulisan ini adalah bagaimana leksikon-leksikon diungkap dengan semua variannya pada masa pandemi ini. Penelitian ini menggunakan metode deskriptif untuk memaparkan leksikon dalam masa pandemi dengan menggunakan teori (Kridalaksana, 2009b) dan (Verhaar, 2001) mengenai morfologi. Data diunduh dari media daring yang memiliki leksikon seputar Covid-19, yaitu Budi, 2020 dan Pasys, 2020 Temuannya adalah leksikon masa pandemi Covid-19 dinyatakan dalam leksem primer (LP) sebesar 33,3%, leksem skunder (LS) sebesar 52,4%, dan singkatan sebesar 14,3%. Leksikon tersebut merupakan leksikon yang khas yang muncul akibat mewabahnya Covid-19. Leksikon masker, Covid-19, karantina wilayah, kenormalan baru, zona merah, bekerja dari rumah (BDR), dan PSBB adalah leksikon yang sangat dikenal oleh penutur bahasa Indonesia pada masa pandemi Covid-19. Selain itu, leksikon tersebut dikaitkan dengan penanda suatu peristiwa sejarah dalam hal ini Covid-19, seperti peristiwa sejarah yang terjadi pada wabah cacar, kolera, kuning yang memiliki kekhasan leksikon yang digunakan
ANALISIS STRUKTURAL TERHADAP INFORMASI KITAB SUCI : MITIGASI BENCANA HYDROMETEOROLOGI DARI PENGALAMAN NABI YUSUF AS
Authors: Sudarma Momon 
Published: October 2021

al-Qur’an adalah salah satu sumber Kitab Suci yang bisa dijadikan sumber informasi. Dalam perspektif Islam, al-Qur’an bukan saja sumber etika beragama, melainkan juga sumber etika dan panduan perilaku dalam merespon lingkungan dan kehidupan. Di dalamnya terdapat aturan, kisah, atau pedoman yang dapat dijadikan pedoman dalam merumuskan kode etik hidup dan kehidupan, termasuk dalam merespon bencana. Kisah Nabi Yusuf AS, memberikan kode informasi dalam kaitannya dengan mitigasi Bencana Hydrometeorologi. Wacana ini, berusaha secara kritis, melakukan studi kepustkaan, terhadap ayat-ayat mitigas, khususnya dalam Kisah Yusuf As. Dalam temuan ini, terkonstruksi langkah strategis mitigasi, yaitu (1) pengumpulan data dan informasi, baik local maupun scientific knowledge, (2) membangun jaringan informasi dan komunikasi, (3) staffing yang professional, dan (4) menyusun program strategis.