bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coal–rock damage characteristics caused by blasting within a reverse fault and its resultant effects on coal and gas outburst
Authors: Gao Kui , Huang Ping , Liu Zegong , Liu Jian , Shu ChiMin , Qiao Guodong 
Published: September 2021

AbstractIn view of the coal and gas outburst accidents occur frequently caused by blasting in geological structural belt, in order to study the mechanical characteristics of coal rock in tectonic belt disturbance by blasting and blasting vibration effect influenced on the stability of surrounding rock, coal–rock damage and failure characteristics within a reverse fault caused by a blasting stress wave were investigated using numerical analyses and experiments. According to the experimental results, the causes of coal and gas outburst dynamic disasters within a reverse fault during blasting are analyzed. The outcomes indicated that the crushing circle created by the crack propagation near the blasting hole severely damaged the fault plane and floor rocks adjacent to the footwall of the reverse fault. Fractures also extended to the upper and lower coal seams of the reverse fault; this caused the surface of the coal seam to fall off and severe internal damage. According to theoretical analysis, the reflection of the blasting stress wave propagating to the reverse fault intensified the damage to coal and rock. Elastic strain energy accumulation within the reverse fault structural zone was accompanied by high-stress concentration. The reverse fault tectonic region was destroyed by blasting vibration. It increased gas pressure and caused a weak surface, which provided a channel for gas flow and a dynamic basis for the occurrence of coal and gas outburst. The research results have important theoretical value to reveal the mechanism of coal and gas outburst in tectonic belt induced by blasting.
Selectivity of weak intermolecular forces and precursor state of elementary oxidation reactions, a new insight on Ne* + N2 chemiionization
Authors: Falcinelli Stefano , Vecchiocattivi Franco , Pirani Fernando 
Published: September 2021

AbstractThis paper reports on the collision dynamics of N2 with metastable Ne* promoting chemiionizations, prototype of barrier-less oxidation reactions of great interest for fundamental and applied research. Extending guidelines presented in previous papers for the atom–atom case, an innovative treatment of the reaction stereodynamics involving molecules in a quantum state-to-state resolution conditions is proposed that emphasizes the role of structure and stability of the precursor that is here the reaction transition state. A critical test of such treatment, carried out exploiting a new formulation both of real and imaginary parts of the optical potential driving the reaction dynamics, is represented by the detailed-combined description of all relevant findings, provided by high resolution molecular beam scattering experiments carried out in our and other laboratories. The present analysis casts light on basic electronic rearrangements of such prototype oxidation reaction which are expected to be of fundamental interest for many other reactions involving open shell atoms and free radicals.
Usability of abattoir-acquired pig eyes for refractive excimer laser research
Authors: Topka Marius , Zhang Yao , Bock Antonia , Riedel Peter , Lörner Johannes , Hammer Alexander , Maier Eva , Paulsen Friedrich , Hammer Christian M. 
Published: September 2021

AbstractThe purpose of this study was to elucidate, under which conditions abattoir-acquired pig eyes are suitable for refractive excimer laser experiments. Porcine eyes from tunnel-scalded (n = 5) and tank-scalded (n = 10) pigs were compared to unscalded eyes (n = 5) and to eyes scalded in the laboratory (n = 5). The corneal epithelium was removed before an excimer laser was used to perform a − 8.0 D photoablation. Corneal thickness was measured by optical coherence topography before and after photoablation. The ablation depth was determined with a contour measuring station, the morphology of the ablated areas was characterized by scanning electron microscopy and white-light profilometry. The scalded eyes showed an increase in corneal swelling which gained statistical significance in tank-scalded eyes showing a wedge-shaped opaque stromal lesion in the nasal corneal quadrant. A measurable deterioration of photoablation was only found in tank-scalded eyes that exhibited the opaque lesion. Ablated area morphology was smooth and regular in the unscalded and tunnel-scalded eyes. The tank-scalded eyes showed conspicuous wrinkles. While unscalded eyes should always be preferred for excimer laser laboratory experiments, the data suggest that the use of tunnel-scalded eyes may also be acceptable and should be chosen over tank-scalded eyes.
Mechanical properties of bulk Sylgard 184 and its extension with silicone oil
Authors: Moučka R. , Sedlačík M. , Osička J. , Pata V. 
Published: September 2021

AbstractDue to its simple curing and very good mechanical properties, Sylgard 184 belongs to the most widely and frequently used silicones in many industrial applications such as microfluidics and microengineering. On top of that its mechanical properties are further controllable through the curing temperature, which may vary from ambient temperature up to 200 °C; the lower the curing temperature the lower the mechanical properties (Johnston et al. in J Micromech Microeng 24:7, 2014. 10.1088/0960-1317/24/3/035017). However, certain specialised application may require even a softer binder than the low curing temperature allows for. In this study we show that this softening can be achieved with the addition of silicone oil into the Sylgard 184 system. To this end a series of Sylgard 184 samples with varying silicone oil concentrations were prepared and tested (tensile test, rotational rheometer) in order to determine how curing temperature and silicone oil content affect mechanical properties. Curing reaction of the polymer system was found to observe 2nd order kinetics in all cases, regardless the oil concentration used. The results suggest that within the tested concentration range the silicone oil addition can be used to soften commercial silicone Sylgard 184.
A comparison of head movements tests in force plate and accelerometer based posturography in patients with balance problems due to vestibular dysfunction
Authors: Janc Magdalena , Sliwinska-Kowalska Mariola , Jozefowicz-Korczynska Magdalena , Marciniak Pawel , Rosiak Oskar , Kotas Rafal , Szmytke Zuzanna , Grodecka Joanna , Zamyslowska-Szmytke Ewa 
Published: September 2021

AbstractThis study compares HS posturography on inertial sensors (MediPost) with force platform posturography in patients with unilateral vestibular dysfunction. The study group included 38 patients (age 50.6; SD 11.6) with unilateral vestibular weakness (UV) and 65 healthy volunteers (48.7; SD 11.5). HS tests were performed simultaneously on the force plate and with MediPost sensor attached at L4. Four conditions applied: eyes open/closed, firm/foam. The tests were performed twice, with the head moving at the frequency of 0.3 Hz (HS 0.3) and 0.6 Hz (HS 0.6). Mean sway velocity was significantly lower for MediPost than force plate in 4th condition both in UV and healthy group. For HS 0.3 the differences between devices were marginal; the highest sensitivity (87%) and specificity (95%) were in 4th condition. For HS 0.6 MediPost revealed lower sensitivity than force plate although the surface parameter improved results. MediPost IMU device and force platform posturography revealed a similar ability to differentiate between patients with balance problems in course of vestibular pathology and healthy participants, despite the differences observed between measuring methods. In some tests surface parameter may be more appropriate than sway velocity in improving MediPost sensitivity.
Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues
Authors: Martin Gottfried , Wolf Julian , Lapp Thabo , Agostini Hansjürgen T. , Schlunck Günther , Auw-Hädrich Claudia , Lange Clemens A. K. 
Published: September 2021

AbstractDespite the reported low expression of the primary SARS-CoV-2 receptor ACE2 in distinct ocular tissues, some clinical evidence suggests that SARS-CoV-2 can infect the eye. In this study, we explored potential entry sites for SARS-CoV-2 by viral S protein histochemistry on various ocular tissues and compared the staining patterns with RNA and protein expression of TMPRSS2 and ACE2. Potential viral entry sites were investigated by histochemistry using tagged recombinant viral S protein on 52 ocular tissue samples including specimens of the cornea, conjunctiva, lid margin, lacrimal gland tissue, retina, choroid, and RPE. In addition, ACE2 and TMPRSS2 immunohistochemistry were performed on the same ocular tissue, each with distinct antibodies binding to different epitopes. Lung tissue samples were used as positive controls. Finally, bulk RNA sequencing (RNA-Seq) was used to determine the expression of ACE2 and its auxiliary factors in the tissues mentioned above. S protein histochemistry revealed a positive staining in lung tissue but absent staining in the cornea, the conjunctiva, eye lid samples, the lacrimal glands, the retina and the optic nerve which was supported by hardly any immunoreactivity for ACE2 and TMPRSS2 and scarce ACE2 and TMPRSS2 RNA expression. Negligible staining with antibodies targeting ACE2 or TMPRSS2 was seen in the main and accessory lacrimal glands. In contrast, ocular staining (S protein, ACE2, TMPRSS2) was distinctly present in pigmented cells of the RPE and choroid, as well as in the ciliary body and the iris stroma. S protein histochemistry revealed hardly any SARS-CoV-2 entry sites in all ocular tissues examined. Similarly, no significant ACE2 or TMPRSS2 expression was found in extra- and intraocular tissue. While this study suggest a rather low risk of ocular infection with SARS-CoV-2, it should be noted, that potential viral entry sites may increase in response to inflammation or in certain disease states.
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control
Authors: Zhang Wenliang , You Baiyang , Qi Dake , Qiu Ling , Ripley-Gonzalez Jeffrey W. , Zheng Fan , Fu Siqian , Li Cui , Dun Yaoshan , Liu Suixin 
Published: September 2021

AbstractObesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction. Trimetazidine, a partial inhibitor of lipid oxidation, has been proposed as a metabolic modulator for several cardiovascular pathologies. However, the effects of Trimetazidine on regulating skeletal muscle function are largely unknown. Our present study used cell culture and obese mice models to test a novel hypothesis that Trimetazidine could improve muscle atrophy with similar results to exercise. In C2C12 cells, high palmitic acid-induced atrophy and mitochondrial dysfunction, which could be reversed by the treatment of Trimetazidine. In our animal models, with high-fat diet-induced obesity associated with skeletal muscle atrophy, Trimetazidine prevented muscle dysfunction, corrected metabolic abnormalities, and improved mitochondrial quality control and mitochondrial functions similarly to exercise. Thus, our study suggests that Trimetazidine successfully mimics exercise to enhance mitochondrial quality control leading to improved high-fat diet-induced muscle dysfunction.
Changes in energy metabolism and respiration in different tracheal narrowing in rats
Authors: Segev Yael , Nujedat Haiat , Arazi Eden , Assadi Mohammad H. , Tarasiuk Ariel 
Published: September 2021

AbstractWhy obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that persists following successful obstruction removal. Here, we explored the effect of two different types of tracheal narrowing, i.e., AO and mild airway obstruction (mAO), and its removal on respiratory homeostasis and metabolic physiology. We show that after ten weeks, mAO vs. AO consumes sufficient energy that is required to maintain respiratory homeostasis and thermoregulation. Obstruction removal was associated with largely irreversible increased feeding associated with elevated serum ghrelin, hypothalamic growth hormone secretagogue receptor 1a, and a phosphorylated Akt/Akt ratio, despite normalization of breathing and energy requirements. Our study supports the need for lifestyle eating behavior management, in addition to endocrine support, in order to attain healthy metabolic physiology in OSA patients.
Characterization of magneto-convection in sunspots
Authors: Schmassmann M. , Rempel M. , Bello González N. , Schlichenmaier R. , Jurčák J. 
Published: September 2021

Context. Observations have shown that in stable sunspots, the umbral boundary is outlined by a critical value of the vertical magnetic field component. However, the nature of the distinct magnetoconvection regimes in the umbra and penumbra is still unclear.
Aims. We analyse a sunspot simulation in an effort to understand the origin of the convective instabilities giving rise to the penumbral and umbral distinct regimes.
Methods. We applied the criterion from Gough & Tayler (1966, MNRAS, 133, 85), accounting for the stabilising effect of the vertical magnetic field, to investigate the convective instabilities in a MURaM sunspot simulation.
Results. We find: (1) a highly unstable shallow layer right beneath the surface extending all over the simulation box in which convection is triggered by radiative cooling in the photosphere; (2) a deep umbral core (beneath −5 Mm) stabilised against overturning convection that underlies a region with stable background values permeated by slender instabilities coupled to umbral dots; (3) filamentary instabilities below the penumbra nearly parallel to the surface and undulating instabilities coupled to the penumbra which originate in the deep layers. These deep-rooted instabilities result in the vigorous magneto-convection regime characteristic of the penumbra; (4) convective downdrafts in the granulation, penumbra, and umbra develop at about 2 km s−1, 1 km s−1, and 0.1 km s−1, respectively, indicating that the granular regime of convection is more vigorous than the penumbra convection regime, which, in turn, is more vigorous than the close-to-steady umbra; (5) the GT criterion outlines both the sunspot magnetopause and peripatopause, highlighting the tripartite nature of the sub-photospheric layers of magnetohydrodynamic (MHD) sunspot models; and, finally, (6) the Jurčák criterion is the photospheric counterpart of the GT criterion in deep layers.
Conclusions. The GT criterion as a diagnostic tool reveals the tripartite nature of sunspot structure with distinct regimes of magneto-convection in the umbra, penumbra, and granulation operating in realistic MHD simulations.
Veränderungen des Alveolarknochens nach Gaumennahterweiterung
und Therapie mit festsitzenden Apparaturen
Authors: Jung Britta A. 
Published: September 2021

Material und MethodenIm Rahmen einer retrospektiven Kohortenstudie wurden die DVT-Datensätze
von 45 Patienten (durchschnittliches Alter: 13,01 Jahre) mit klassischer
Gaumennahterweiterung und Edgewise-Therapie analysiert. Die Studie untersuchte
die Fragestellung, ob die Variablen Patientenalter, Expansionsweite,
Behandlungsdauer sowie die initiale Knochendicke Einfluss auf die bukkale
Knochendicke nach Therapie haben. Es wurden die Null-Hypothesen untersucht: (a)
es gibt keine Unterschiede zwischen der Knochendicke und anatomischen Defekten
im Bereich des bukkalen Alveolarknochens vor und nach der Therapie, (b) die
Dicken des bukkalen Alveolarknochens und anatomischen Defekte korrelieren nicht
mit dem Alter der Patienten, der Expansionsmenge, dem Behandlungszeitpunkt und
der initialen Knochendicke. Es wurden bei allen Patienten DVTs vor der
Behandlung (T1) und nach der Behandlung (T2) ausgewertet.
Predicting voice choice in symmetrical voice languages
Authors: Riesberg Sonja , Bardají i Farré Maria , Malcher Kurt , Himmelmann Nikolaus P. 
Published: September 2021

AbstractWestern Austronesian symmetrical voice languages exhibit at least two basic transitive constructions. This paper investigates what factors influence speakers’ choice of one voice over another in natural spoken discourse. It provides a thorough assessment of all factors that have been proposed to be relevant for voice choice in the literature on symmetrical voice systems. Using the Indonesian language Totoli as a case study, we show that unlike in languages with asymmetrical voice alternations, argument-related properties such as topicality, activation state, animacy, etc. do not play a major role in voice choice in symmetrical voice languages. We argue that for symmetrical voice alternations other factor groups are relevant than for asymmetrical voice alternations and that the clear structural differences between the two alternation types are mirrored in functional differences.
Biomechanical responses to landing strategies of female artistic gymnasts
Authors: Straker Rebecca , Exell Timothy A. , Farana Roman , Hamill Joseph , Irwin Gareth 
Published: September 2021

ABSTRACTInconsistencies between sexes in the landing criteria provided by the international gymnastics governing body (FIG) may predispose female gymnasts to lower extremity injury. This study aimed to investigate lower extremity biomechanics when performing the male and female landing strategy. Seven collegiate, female gymnasts (age: 20.5 ± 1.2 years, height: 1.64 ± 0.06 m, mass: 60.4 ± 10.2 kg) performed drop landings using the prescribed women's and men's landing strategy. Kinematic and kinetic data from 10 trials of each landing strategy were collected. Differences between landing strategy at individual and group level for key injury risk variables of the lower limb were explored. Group differences (p ≤ .05) were reported in the sagittal range of motion (ROM) at the knees and hips, with the men's landing strategy eliciting a larger ROM decelerating the body upon impact. Large inter and intra‐individual variation was apparent with different movement responses shown across individuals and demonstrating degeneracy as gymnasts satisfied the overall landing objective. These results indicate an individually favoured landing strategy to fulfil the informational constraints and hence supporting the use of a single‐subject design. The current study emphasises the potential injury risk associated with the different informational constraints placed on females’ landing strategy by the FIG, whilst recognising the individual gymnasts’ task response.Highlights
An increase in the range of motion at the knee and hip may support the recommendation of the men's landing style.
Gymnasts appear to utilise individual landing strategies to complete the landing objective, supporting the use of a single‐subject design.
Genomic organization of the autonomous regulatory domain of eyeless locus in Drosophila melanogaster
Authors: Verma Shreekant , Pathak Rashmi U , Mishra Rakesh K 
Published: September 2021

Abstract
In Drosophila, expression of eyeless (ey) gene is restricted to the developing eyes and central nervous system. However, the flanking genes, myoglianin (myo), and bent (bt) have different temporal and spatial expression patterns as compared to the ey. How distinct regulation of ey is maintained is mostly unknown. Earlier, we have identified a boundary element intervening myo and ey genes (ME boundary) that prevents the crosstalk between the cis-regulatory elements of myo and ey genes. In the present study, we further searched for the cis-elements that define the domain of ey and maintain its expression pattern. We identify another boundary element between ey and bt, the EB boundary. The EB boundary separates the regulatory landscapes of ey and bt genes. The two boundaries, ME and EB, show a long-range interaction as well as interact with the nuclear architecture. This suggests functional autonomy of the ey locus and its insulation from differentially regulated flanking regions. We also identify a new Polycomb Response Element, the ey-PRE, within the ey domain. The expression state of the ey gene, once established during early development is likely to be maintained with the help of ey-PRE. Our study proposes a general regulatory mechanism by which a gene can be maintained in a functionally independent chromatin domain in gene-rich euchromatin.
Objectively Measured Patterns of Daily Physical Activity and Phenotypic Frailty
Authors: Wanigatunga Amal A , Cai Yurun , Urbanek Jacek K , Mitchell Christine M , Roth David L , Miller Edgar R , Michos Erin D , Juraschek Stephen P , Walston Jeremy , Xue Qian-Li , Appel Lawrence J , Schrack Jennifer A 
Published: September 2021

Abstract

Background
Self-reported low physical activity is a defining feature of phenotypic frailty but does not adequately capture physical activity performed throughout the day. This study examined associations between accelerometer-derived patterns of routine daily physical activity and frailty.

Methods
Wrist accelerometer and frailty data from 638 participants (mean age 77 [SD = 5.5] years; 44% women) were used to derive 5 physical activity metrics: active minutes/day, sedentary minutes/day, total activity counts/day, activity fragmentation (reciprocal of the average active bout length), and sedentary fragmentation (reciprocal of the average sedentary bout length). Robust, prefrail, and frail statuses were identified using the physical frailty phenotype defined as having 0, 1–2, or ≥3 of the following criterion: weight loss, exhaustion, slowness, self-reported low activity, and weakness. Frailty was collapsed into not frail (robust and prefrail) and frail, and each frailty criteria was dichotomized. Multiple logistic regression was used to model each accelerometer metric. Separate frailty criteria and interactions with age and sex were also examined.

Results
With higher amounts and intensity of daily activity (more active minutes, fewer sedentary minutes, higher activity counts) and lower activity fragmentation, the odds of frailty were lower compared to robust/prefrail states (p &lt; .02 for all). For interactions, only an age by sedentary fragmentation interaction on the odds of frailty was observed (p = .01). For each separate criteria, accelerometer metrics were associated with odds of slowness, low activity, and weakness.

Conclusion
Less favorable patterns of objectively measured daily physical activity are associated with frailty and the components of slowness, low self-reported activity, and weakness.