bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of non-hereditary amyloidosis in Poland
Authors: Grzeszczak Wladyslaw , Franek Edward , Szypowska Agnieszka , Filipow Winicjusz , Zięba Mariusz , Kabicz Paweł , Więckowska Barbara 
Published: October 2021

WstępW pracy przedstawiono przypadki niedziedzicznej amyloidozy na podstawie danych z publicznej służby zdrowia w Polsce, obejmujących zarówno pacjentów hospitalizowanych, jak i ambulatoryjnych. Dane przedstawiono według podtypów amyloidozy rozpoznanych w okresie od 2013 r. do 2015 r.Materiał i metodyPacjenci z amyloidozą zostali wyłonieni z bazy danych Narodowego Funduszu Zdrowia.
W celu zapewnienia, że zgłaszane dane dotyczące zachorowalności obejmowały tylko nowych pacjentów, osoby już wcześniej wpisane do rejestru z rozpoznaniem amyloidozy zostały wykluczone. Do badania włączono dzieci i dorosłych obojga płci. Obszar geograficzny (miejsce zamieszkania badanych) podzielono na sześć regionów. We wszystkich regionach Polski mieszkają osoby o porównywalnym genomie.WynikiW latach 2013–2015 amyloidozę stwierdzono łącznie u 287 pacjentów, z częstością 2,49 na milion osobolat. Najczęstszą z chorób była amyloidoza nieokreślona, cierpiało z jej powodu 169 pacjentów (1,46 na milion osobolat). Druga co do częstości występowania była amyloidoza ograniczona do określonego narządu – 60 pacjentów (0,52 na milion osobolat). Biorąc pod uwagę wszystkie analizowane podtypy amyloidozy, mężczyźni chorowali częściej niż kobiety. Nie stwierdzono statystycznie istotnej różnicy między zarejestrowaną zapadalnością w analizowanych regionach. Brak istotnych różnic między mężczyznami i kobietami z amyloidozą starczą.WnioskiCzęstość występowania amyloidozy w Polsce wynosi około 2,49 na milion osobolat, z nieco większym ryzykiem zachorowań u mężczyzn niż u kobiet. Badani chorowali najczęściej na amyloidozę o nieokreślonej przyczynie niezwiązaną z dziedziczeniem. Na drugim miejscu pod względem częstości występowania była amyloidoza ograniczona narządowo. Brak istotnych statystycznie różnic pomiędzy zarejestrowaną zapadalnością na amyloidozę w analizowanych regionach Polski. Nie wykazano istotnych różnic pomiędzy kobietami i mężczyznami chorującymi na amyloidozę starczą.
Bipolar pulsed radiofrequency neuromodulation of median nerve for treatment of carpal tunnel syndrome – a preliminary study
Authors: Krzywda Adam , Wypych-Ślusarska Agata , Krupa-Kotara Karolina , Oleksiuk Klaudia , Głogowska-Ligus Joanna , Skrzypek Michał , Słowiński Jerzy 
Published: October 2021

WstępWyniki chirurgicznego odbarczenia nerwu pośrodkowego u części chorych z zespołem cieśni nadgarstka są niezadowalające. Celem pracy jest ocena wczesnych wyników leczenia zespołu cieśni nadgarstka (<i>carpal tunnel syndrome</i> – CTS) za pomocą bipolarnej neuromodulacji nerwu pośrodkowego (<i>median nerve</i> – MN) z użyciem prądu o częstotliwości radiowej w trybie pulsacyjnym (<i>pulsed radiofrequency</i> – PRF).Materiał i metodyLeczeniu poddano 15 dorosłych pacjentów z CTS (10 kobiet i 5 mężczyzn, średni wiek 58,5 roku). Zastosowano technikę bipolarnej neuromodulacji z użyciem prądu PRF. Prawidłowość położenia elektrod potwierdzano neurofizjologicznie. Protokół badania składał się z kwestionariusza objawów zespołu cieśni nadgarstka (Boston Carpal Tunnel Questionnaire – BCTQ), skali numerycznej NRS (Numerical Rating Scale) dla oceny bólu oraz oceny siły mięśniowej przed neuromodulacją oraz 4 i 12 tygodni po leczeniu. Ponadto oceniano szybkość przewodnictwa czuciowego w nerwie pośrodkowym (<i>sensory nerve conduction velocity</i> – SNCV) przed i 12 tygodni po interwencji.WynikiStwierdzono znamienną poprawę w zakresie podskal BCTQ dotyczących ciężkości objawów (33,53 ± 8,25 przed zabiegiem vs. 18,33 ± 11,06 i 25,67 ± 12,39 po upływie 4 i 12 tygodni od zabiegu) oraz stanu czynnościowego (21,0 ± 5,79 vs. 12,07 ± 7,20 i 17,73 ± 9,09), a także poprawę siły mięśniowej (3,39 ± 1,68 vs. 5,86 ± 1,98 i 4,93 ± 2,22). Ponadto stwierdzono redukcję bólu i poprawę SNCV, jednak parametry te nie osiągnęły znamienności statystycznej.WnioskiNeuromodulacja nerwu pośrodkowego za pomocą prądu PRF przeprowadzona techniką bipolarną jest obiecującą metodą leczenia pacjentów z CTS i może być alternatywą dla chirurgicznego uwolnienia nerwu pośrodkowego. Dla oceny trwałości poprawy klinicznej po zastosowanym leczeniu konieczny będzie dłuższy okres obserwacji.
Legitimasi Kedudukan Kepala Desa dalam Penyelesaian Sengketa Agraria
Authors: Dewi Sri Anggraini Kusuma , Hasibuan Rezky Panji Perdana Martua 
Published: October 2021

The agrarian disputes often occur in rural areas, considering that the majority of the livelihoods of rural communities are farmers. In this regard, rural communities also cannot be avoided from agrarian conflicts that occur between residents, including in terms of inheritance. This social legal research aims to analyze the factors causing the occurrence of agrarian conflicts in rural areas; and explain the role of the village head in dealing with disputes related to land. This empirical legal research uses a qualitative approach that is based on primary data and secondary data as obtained through a series of observations, interviews, and documentation. The results of the study indicate that rural communities tend to choose the head of village as the party that resolves agrarian disputes in rural areas. Therefore, the rural community perspective believes and considers the head of village to be able to provide a sense of community justice. The scheme used by the head of village is mediation or what is often called 'deliberation for consensus'.
KEYWORDS: Land, Customary Law, Head of Village, Amadanom, Malang.
AS JOIAS TRADICIONAIS EM FILIGRANA NAS FESTAS RELIGIOSAS DE NATIVIDADE - TOCANTINS
Authors: FERNANDES BONFIM WÁTILA MISLA , BALSAN ROSANE 
Published: October 2021

Resumo
O ofício da ourivesaria e a arte dos mestres filigraneiros, aponta Iphan (2007) não pode ser visto desatrelada de outras manifestações religiosas nativitanas, como a celebração do Divino Espírito Santo, a festa da padroeira Nossa Senhora da Natividade e a festa do Nosso Senhor do Bonfim, bem como a confecção de bolos e biscoitos de D. Naninha – está tudo entrelaçado: as festas, as práticas, personagens e saberes que identificam a cultura imaterial de Natividade. Desse modo, o presente artigo busca demostrar a relação das joias artesanais que marcam o espaço e lugar nativitano e as festas religiosas seculares e presentes no dia a dia e no imaginário local.
HISTÓRIA NA BASE NACIONAL COMUM CURRICULAR DO ENSINO MÉDIO: ALGUNS APONTAMENTOS
Authors: SIQUEIRA ALVES VÂNIA MARIA 
Published: October 2021

Na tradição federativa do Brasil, coube aos diferentes sistemas de ensino, ao longo de décadas, elaborar e implementar orientações curriculares oficiais em suas redes de escolas. Com a intenção de orientá-los foi elaborado a Base Nacional Comum Curricular (BNCC). O trabalho abordará o componente curricular História na BNCC para o ensino médio, buscando analisar a proposição de organização e direcionamentos deste componente curricular para constituir o conhecimento escolar que se ensinará e se aprenderá nas escolas. Para tanto, optou-se pelo uso de metodologia de análise documental e bibliográfica. Nesse nível de ensino, a implementação da BNCC faz parte das mudanças propostas pela Reforma do novo Ensino Médio. O ensino por competências se destaca no documento e na Reforma.

Palavras-chave: BNCC; ensino médio; ensino de História.
História pública e história da música do Brasil e a criação do site A Música de: História Pública da Música do Brasil
Authors: Lopes Saraiva Daniel 
Published: October 2021

A história pública tem ganhado destaque no meio historiográfico, ao mesmo tempo em que temos visto um crescimento vertiginoso no mercado editorial, principalmente no que concerne à relação entre história e biografia. Diante disso, o artigo aqui proposto tem como objetivo discutir algumas das possíveis relações entre história oral, história pública, história do tempo presente e história da música. Para isso, são analisados alguns livros e um projeto que contempla a relação entre os estudos acadêmicos sobre a música e suas reverberações para além da universidade. Por fim, são apresentados o projeto A música de: história pública da música do Brasil, que tem como objetivo constituir uma plataforma ampla sobre o tema, e os alguns pontos da entrevista com o cantor Edy Star feita para o site A música de: história pública da música do Brasil são analizados no artigo.
TENDÊNCIAS DA PRODUÇÃO DA AGRICULTURA FAMILIAR NA REGIÃO DE MARABÁ, PARÁ
Authors: Teixeira junior Tiese Rodrigues , De Abreu Monteiro Maurílio 
Published: October 2021

Reconhecendo que a agricultura familiar tem estatuto e dinâmicas conceituais próprias e tendo por base o tratamento de dados dos Censos Agropecuários de 1996 e 2006 e do Cadastro Ambiental Rural de 2016, a pesquisa demonstra algumas tendências no agrário da região de Marabá.Pa. A realização de pesquisa de campo, norteada por leituras das redes de laços sociossimbólicos, indica, por exemplo, um processo de pecuarização da agricultura familiar na região atravessado por ações práticas tomadas, as vezes, de forma inconscientes refletindo produtos do habitus ajustado a um conjunto marcado por um jogo social no qual estes agentes sociais têm respondido com ações práticas voltadas, primeiramente, a garantir o sustento cotidiano da família.
Countermarketing About Fruit Drinks, Alone or With Water Promotion: A 2019 Randomized Controlled Trial in Latinx Parents
Authors: Krieger James , Kwon Taehoon , Ruiz Rudy , Walkinshaw Lina Pinero , Yan Jiali , Roberto Christina A. 
Published: October 2021

Objectives. To test whether fruit drink countermarketing messages alone or combined with water promotion messages reduce Latinx parents’ purchases of fruit drinks for children aged 0 to 5 years. Methods. We performed a 3-arm randomized controlled online trial enrolling 1628 Latinx parents in the United States during October and November 2019. We assessed the effect of culturally tailored fruit drink countermarketing messages (fruit drink‒only group), countermarketing and water promotion messages combined (combination group), or car-seat safety messages (control) delivered via Facebook groups for 6 weeks on parental beverage choices from a simulated online store. Results. The proportion of parents choosing fruit drinks decreased by 13.7 percentage points in the fruit drink‒only group (95% confidence interval [CI] = −20.0, −7.4; P < .001) and by 19.2 percentage points in the combination group (95% CI = −25.0, −13.4; P < .001) relative to control. Water selection increased in both groups. Conclusions. Fruit drink countermarketing messages, alone or combined with water promotion messages, significantly decreased parental selection of fruit drinks and increased water selection for their children. Public Health Implications. Countermarketing social media messages may be an effective and low-cost intervention for reducing parents’ fruit drink purchases for their children. (Am J Public Health. 2021;111(11):1997–2007. https://doi.org/10.2105/AJPH.2021.306488 )
Mathematical Modelling to Determine the Greatest Height of Trees
Authors: Kanahama Tohya , Sato Motohiro 
Published: October 2021

Abstract
This study aimed to analyse the critical height of a column whose weight varies vertically in order to obtain a simple scaling law for a tree where the weight distribution considered. We modelled trees as cantilevers that were fixed to the ground and formulated a self-buckling problem for various weight distributions. A formula for calculating the critical height was derived in a simple form that did not include special functions. We obtained a theoretical clarification of the effect of the weight distribution of heavy columns on the buckling behaviour. A widely applicable scaling law for trees was obtained. We found that an actual tree manages to distribute the weight of its trunk and branches along its vertical extent in a manner that adequately secures its critical height. The method and findings of this study are applicable to a wide range of fields, such as the simplification of complicated buckling problems and the study of tree shape quantification.
Racial/ethnic Disparities on Inflammation and Response to Methylprednisolone in Severe Covid-19 Pneumonia
Authors: Go Ronaldo C. , Nyirenda Themba , Bojarian Maryam , Hosseini Davood Karimi , Kim Kevin , Rahim Mehek , Paleoudis Elli Gourna , Go Anna C. , Han Zhihong , Sperber Steven J , Gupta Anjali 
Published: October 2021

Abstract
BACKGROUNDRacial/Ethnic minorities are at higher risk for Severe COVID-19. This may be related to social determinants that lead to chronic inflammatory states. The aims of the study were to determine if there are racial/ethnic differences between the inflammatory markers of survivors and non-survivors and if there was a dose dependent association of methylprednisolone to in hospital survival. METHODSThis was a secondary analysis of a retrospective cohort. Patients were older than 18 years of age and admitted for severe COVID-19 Pneumonia Between March to June 2020 in 13 Hospitals in New Jersey, United States. Comparison of inflammatory markers used Kruskal-Wallis followed by pairwise comparison using two-sided Wilcoxon rank sum test. A Youden Index Method was used to determine the cut-off between low dose and high dose methylprednisolone. For each racial/ethnic group, cox regression was used to determine the association to survival between no methylprednisolone and methylprednisolone (high dose versus low dose). RESULTSPropensity matched sample (n=759) between no methylprednisolone (n=380) and methylprednisolone (n=379) had 338 Whites, 102 Blacks, 61 Asian/Indians, and 251 Non-Black Non-White Hispanics. Interleukin-6, C-reactive protein, ferritin, and d-dimer values were higher in non-survivors compared to survivors except in Asian/Indian survivors who had higher ferritin values compared to non-survivors (median: 1,265 vs 418 ug/L, P=0.0211). Black and Hispanic survivors had persistently elevated C-reactive protein, (10.2 mg/mL) and (13.70 mg/mL) respectively. Low dose methylprednisolone was associated with prolonged 60 days in hospital survival over no methylprednisolone in Whites (P<0.0001), Asian/Indians (P=0.0180), and Hispanics (P=0.0004). Regardless of dose, methylprednisolone was not associated with prolonged survival in Blacks. High dose methylprednisolone was associated with worse survival in Hispanics. (P=0.0181). CONCLUSIONRacial/Ethnic disparities with inflammatory markers in survivors and non-survivors preclude the use of one marker as predictor of survival. Low dose methylprednisolone is associated with prolonged survival in Asian/Indians, Hispanics, and Whites. Methylprednisolone, regardless of dose, was not associated with prolonged survival in Blacks.
CD34+THY1+ Synovial Fibroblast Subset in Arthritic Joints Has High Osteoblastic and Chondrogenic Potentials in Vitro
Authors: Noda Seiji , Hosoya Tadashi , Komiya Yoji , Tagawa Yasuhiro , Endo Kentaro , Komori Keiichiro , Koga Hideyuki , Takahara Yasuhiro , Sugimoto Kazutaka , Sekiya Ichiro , Saito Tetsuya , Mizoguchi Fumitaka , Yasuda Shinsuke 
Published: October 2021

Abstract
Objective: Synovial fibroblasts (SF)s in rheumatoid arthritis (RA) and osteoarthritis (OA) play biphasic roles in joint destruction and regeneration of bone/cartilage as mesenchymal stem cells (MSC)s. Although MSCs contribute to joint homeostasis, such function is impaired in arthritic joints. We have identified functionally distinct three SF subsets characterized by the expression of CD34 and THY1 as follows: CD34+THY1+, CD34-THY1- and CD34-THY1+. The objective of this study was to clarify the differentiation potentials as MSCs in each SF subset since both molecules would be associated with the MSC function.Methods: SF subsets were isolated from synovial tissues of 70 patients (RA: 18, OA: 52). Expressions of surface markers associated with MSCs (THY1, CD73, CD271, CD54, CD44 and CD29) were evaluated in fleshly-isolated SF subsets by flow cytometry. The differentiation potentials of osteogenesis, chondrogenesis, and adipogenesis were evaluated with histological staining and quantitative polymerase chain reaction of differentiation marker genes. Small interfering RNA was examined to deplete THY1 in SFs. Results: The expression levels of THY1+, CD73+ and CD271+ were highest and those of CD54+ and CD29+ were lowest in CD34+THY1+ among three subsets. Comparing three subsets, the calcified area, alkaline phosphatase (ALP)-stained area and cartilage matrix subset were the largest in CD34+THY1+ subset. Consistently, the expressions of differentiation markers of the osteoblasts (RUNX2, ALPL and OCN) or chondrocytes (ACAN) were the highest in CD34+THY1+ subset, indicating that CD34+THY1+ subset possessed the highest osteogenic and chondrogenic potential among three subsets. While the differentiation potentials to adipocytes were comparable among the subsets regarding lipid droplet formations and the expression of LPL and PPARγ. The knockdown of THY1 in bulk SFs resulted in impaired osteoblast differentiation indicating some functional aspects in this stem-cell marker. Conclusion: CD34+THY1+ SF subset has high osteogenic and chondrogenic potentials. The preferential enhancement of MSCs functions in CD34+THY1+ subset may provide a new treatment strategy for regenerating damaged bone/cartilage in arthritic joints.
Identification of Fruit Firmness QTL ff2.1 by SLAF-BSA and QTL Mapping in Melon
Authors: Dai Dongyang , Zeng Shuang , Wang Ling , Li Junfeng , Ji Peng , Liu Huiying , Sheng Yunyan 
Published: October 2021

Abstract
Fruit firmness is an important target of melon breeding, as it is associated with shelf life and economic value; however, the precise mechanism determining fruit firmness during fruit ripening remains elusive. In the present study, one hundred forty-four F2 plants and F2-3 families derived from the high-firmness melon line M2-10 and the low-firmness melon line ZT091 were used to identify major quantitative trait loci (QTLs) by specific-locus amplified fragment (SLAF) sequencing with bulked segregant analysis (BSA). Simple sequence repeat (SSR) and cleaved amplified polymorphic sequence (Caps) markers based on the resequencing of parental lines were also used to narrow the associated region to identify candidate genes. Two regions associated with fruit firmness were investigated, including a 4.87 Mb region on chr. 2 and a 28.7 Mb region on chr. 5 of the melon genome. SSR and Caps markers were used to construct a genetic map of the associated regions: QTL ff5.1 was located between CmSSR13509 and CmSSR13423 and explained 38.44% of the observed variation, with an LOD threshold of 17.44; ff2.1 was located between CmSSR07709 and SNP22228 and explained 28.14% of the variation, with an LOD threshold of 3.8, and this region included 106 Kb and 10 candidate genes. Quantitative Real-time PCR (qRT-PCR) was used to investigated the investigate candidate gene expression at 15, 20 and 25 days after pollination (DAP) in the parental lines, and significant expression levels were detected for most of the genes, including four genes of unknown function and MELO3C017519, MELO3C017520, MELO3C017522, MELO3C029506, and MELO3C029520. These results revealed a new QTL, ff2.1, for melon fruit firmness-related gene identification.
Predictive Value of Immune Genomic Signatures From Breast Cancer Cohorts Containing Data for Both Response to Neoadjuvant Chemotherapy and Prognosis After Surgery
Authors: Zhu Yidan , Iwamoto Takayuki , Kajiwara Yukiko , Takahashi Yuko , Kochi Mariko , Shien Tadahiko , Taira Naruto , Toyooka Shinichi , Doihara Hiroyoshi 
Published: October 2021

Abstract
BackgroundPrevious studies of immune-related gene signatures (IGSs) in breast cancer have attempted to predict the response to chemotherapy or prognosis and were performed using different patient cohorts. The purpose of this study was to evaluate the predictive functions of various IGSs using the same patient cohort that included data for response to chemotherapy as well as the prognosis after surgery.MethodsWe applied five previously described IGS models in a public dataset of 508 breast cancer patients treated with neoadjuvant chemotherapy. The prognostic and predictive values of each model were evaluated, and their correlations were compared.ResultsWe observed a high proportion of expression concordance among the IGS models (r: 0.56-1). Higher gene expression scores of IGSs were detected in aggressive breast cancer subtypes (basal and HER2-enriched) (P < 0.001). Four of the five IGSs could predict chemotherapy responses and two could predict 5-year relapse-free survival in cases with hormone receptor-positive (HR+) tumors. However, the models showed no significant differences in their predictive abilities for hormone receptor-negative (HR-) tumors.ConclusionsIGSs are, to some extent, useful for predicting prognosis and chemotherapy response; moreover, they show substantial agreement for specific breast cancer subtypes. However, it is necessary to identify more compelling biomarkers for both prognosis and response to chemotherapy in HR- and HER2+ cases.
Prevalence and Factors Associated With Adverse Drug Events Among Patients On Dolutegravir-Based Regimen At The Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: A Retrospective Cross-Sectional Study.
Authors: Namulindwa Angella , Wasswa John Hans , Muyindike Winnie , Tamukong Robert , Oloro Joseph 
Published: October 2021

Abstract
Background: Highly Active Antiretroviral Therapy is efficacious in suppression of Human Immunodeficiency Virus (HIV) however, it is associated with numerous toxicities hence great effort has been put into development of antiretrovirals with better tolerability. The World Health Organization recommended dolutegravir as first-line antiretroviral therapy however, recent studies have raised concerns regarding its safety in real-clinical settings due to adverse drug reactions (ADEs). Hence the purpose of this study was to establish the prevalence and factors associated with adverse drug events among patients on dolutegravir-based regimen at the Immune Suppression Syndrome (ISS) Clinic- Mbarara Regional Referral Hospital (MRRH).Methods: A retrospective cross-sectional study was conducted at ISS Clinic-MRRH among 375 randomly selected patients who had been exposed to DTG-based regimen for at least 12 weeks. The patients were interviewed to obtain data on sociodemographics, dietary habits and thereafter their files reviewed to obtain data on ADEs. Data entry was done using Epi-data 3.0 and exported to SPSS version 25.0 for analysis. The prevalence of ADEs was determined as a percentage, and ADE associated factors were assessed using bivariate analysis, those found significant were further subjected to multivariate logistic regression model and were considered significant at P<0.05.Results: The prevalence of adverse drug events among patients on DTG-based regimen was found to be 33.1% (124/375) with 5.6% (7/124) participants discontinued from treatment due ADEs, 4 of which were due to hyperglycemia and 3 due to liver toxicity. The commonly experienced ADEs included abdominal pain, hyperglycemia and liver toxicity each at 7.3%, headache at 11.3%, and allergy at 36.3%. Male sex (AOR 1.571, 95% CI 1.433- 1.984), WHO stage one at entry to care (AOR 4.586, 95% CI 1.649-12.754), stage two (AOR 4.536, 95% CI 1.611-12.776), stage three (AOR 3.638, 95% CI 1.262-10.488), were significantly associated with ADEs. Patients with undetectable viral load at initiation of DTG-based regimen were less likely to experience ADEs (AOR = .324, 95% CI .1167-.629).Conclusions: Up to a third of patients on DTG-based regimen experienced ADEs. Male sex, WHO HIV disease stage and a detectable viral load at initiation of DTG-based regimen were significantly associated with ADEs. It is crucial to actively monitor patients with these characteristics for ADEs.