bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness Analysis of Camrelizumab Versus Chemotherapy as Second-Line Treatment of Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Authors: Cai Hongfu , Xu Baohua , Li Na , Zheng Bin , Zheng Zhiwei , Liu Maobai 
Published: November 2021

Background: This study aimed to analyze the cost effectiveness of camrelizumab in the second-line treatment of advanced or metastatic esophageal squamous cell carcinoma in China.Methods: On the basis of the ESCORT clinical trial, a partitioned survival model was constructed to simulate the patient’s lifetime quality-adjusted life years (QALYs), lifetime costs, and incremental cost-effectiveness ratio (ICER). One-way sensitivity and probability sensitivity analyses were performed to test the stability of the model.Results: Treatment of esophageal squamous cell carcinoma with camrelizumab added 0.36 QALYs and resulted in an incremental cost of $1,439.64 compared with chemotherapy, which had an ICER of $3,999 per QALY gained. The ICER was far lower than the threshold of willingness to pay for one time the GDP per capita in China. Sensitivity analysis revealed that the ICERs were most sensitive to the cost of drugs, but the parameters did not have a major effect on the results of the model.Conclusion: Camrelizumab is likely to be a cost-effective option compared with chemotherapy for patients with advanced or metastatic esophageal squamous cell carcinoma. This informs patient selection and clinical path development.
How to Support Parents of Infants and Young Children in Mental Health Care: A Narrative Review
Authors: Stolper Hanna , van Doesum Karin , Steketee Majone 
Published: November 2021

Objective: The aim of this narrative review is to gain insight into the appropriate intervention targets when parents of infants and young children suffer from psychopathology.Background: Psychopathology in parents is a risk factor for maladaptive parenting and is strongly related to negative cascade effects on parent-child interactions and relations in the short and long term. Children in their first years of life are especially at risk. However, in adult mental health care, this knowledge is rarely translated into practice, which is a missed opportunity for prevention.Methods: Electronic databases were searched for reviews and meta-analysis. In addition, sources were obtained via manual search, reference mining, expert opinion, and communications from conferences. In total, 56 papers, whereof 23 reviews and 12 meta-analyses were included.Results: Findings regarding targets of intervention were identified in different interacting domains, namely the parental, family, child, and environmental domains as well as the developing parent-child relationship. A “one size fits all” intervention is not appropriate. A flexible, tailored, resource-oriented intervention program, multi-faceted in addressing all modifiable risk factors and using different methods (individual, dyadic, group), seems to provide the best results.Conclusion: To address the risk factors in different domains, adult and child mental health care providers should work together in close collaboration to treat the whole family including mental disorders, relational, and contextual problems. A multi-agency approach that includes social services is needed.
The Promotion of Creativity of Vocational College Students: The Role of Parent-Child Relationship, Emotional Intelligence, and Grit
Authors: Wu Yushen , Wu Yubin , Chong Daohan , Zhang Wen 
Published: November 2021

Objective: To examine whether emotional intelligence played a mediation role in the association between parent-child relationship and vocational college student’s creativity, and whether grit moderated this mediating process.Methods: 663 vocational college students participated in this study and completed four questionnaires at three time points, which included measures of parent-child relationship, creativity, emotional intelligence, and grit.Results: (1) Emotional intelligence mediated the relationship between parent-child relationship and vocational college student’s creativity; (2) grit moderated the mediating role of emotional intelligence between parent-child relationship and vocational college student’s creativity.Conclusion: Parent-child relationship had both direct effects on vocational college student’s creativity and indirect effects through emotional intelligence. Grit moderates the effect of emotional intelligence on vocational college student’s creativity.
Callous-Unemotional Traits Moderate the Relationship Between Irritability and Threatening Responding
Authors: Zhang Ru , Bashford-Largo Johannah , Lukoff Jennie , Elowsky Jaimie , Carollo Erin , Schwartz Amanda , Dobbertin Matthew , Bajaj Sahil , Blair Karina S. , Leibenluft Ellen , Blair R. James R. 
Published: November 2021

Background:Irritability and callous-unemotional (CU; reduced guilt/empathy) traits vary dimensionally in the typically developing population but may be particularly marked in youth with conduct disorder (CD). While these dimensional traits are positively correlated, they have been associated with divergent forms of dysfunction, particularly with respect to threat processing (i.e., irritability with increased, and CU traits with decreased, threat responsiveness). This suggests that interactions between these two dimensions may be complex at the neurobiological level. However, this issue has received minimal empirical attention.Methods:The study included 105 adolescents (typically developing and cases with CD;N= 59). They were scanned with fMRI during a looming threat task that involved images of threatening and neutral human faces or animals that appeared to be either looming or receding.Results:Significantirritability-by-CU traits-by-Direction-by-Emotion interactionswere seen within right thalamus/PAG, left lingual gyrus and right fusiform gyrus; irritability was positively associated with the BOLD response for Looming Threatening vs. Receding Threatening trials, particularly for youth with low CU traits. In contrast, CU traits werenegativelyassociated with the same differential BOLD response but particularly for youth showing higher levels of irritability. Similar findings were seen within left ventral anterior and posterior cingulate cortices, though the addition of the interaction with CU traits was only seen at slightly more lenient thresholds.Conclusions:The results support previous work linking irritability to increased, and CU traits to reduced, threat responsiveness. However, for adolescents with high irritability, if CU traits are also high, the underlying neuropathology appears to relate to reduced, rather than increased, threat responsiveness.
Digital Formats for Community Participation in Health Promotion and Prevention Activities: A Scoping Review
Authors: Schroeer Claudia , Voss Stephan , Jung-Sievers Caroline , Coenen Michaela 
Published: November 2021

Objectives:Digital technologies in public health are primarily used in medical settings and mostly on an individual and passive way of use. There are research gaps on digital media facilitating participation, empowerment, community engagement, and participatory research in community settings. This scoping review aims to map existing literature on digital formats that enable participation in the field of health promotion and prevention in community settings.Design:The databases Medline, EMBASE, and PsycINFO were used to identify studies published from 2010 up to date (date of literature search) onward that used digital formats in all or in the main sequences of the process to enable high levels of participation in health promotion and prevention activities in community settings.Results:This review identified nine out of 11 included studies relevant to the research question. We found five studies that applied qualitative participatory research, two studies on peer support and one study each on empowerment and crowdsourcing. The digital technologies used varied widely and included social media platforms, bulletin boards, online forum webpages, and customized web providers and programs. Most studies mentioned anonymity, flexibility, and convenience as benefits of digital interventions. Some papers reported limitations such as difficulties by interpreting written-only data or the possibility of selection bias due to the digital divide.Conclusion:This scoping review identified only few studies relevant to our objective, indicating an existing gap in research on this topic. Digital formats were found to be particularly suitable for purposes where anonymity and flexibility are beneficial, such as for online peer exchange and peer support programs.
Effectiveness of a Non-pharmacological Intervention to Control Diabetes Mellitus in a Primary Care Setting in Kerala: A Cluster-Randomized Controlled Trial
Authors: Rahul Arya , Chintha Sujatha , Anish Thekkumkara Surendran , Prajitha Kannamkottapilly Chandrasekharan , Indu Pillaveetil Sathyadas 
Published: November 2021

Background: Despite being the first Indian state with a dedicated Non-Communicable Disease (NCD) program, glycemic control among a large proportion of patients is low in Kerala. This study tries to find evidence for a standardized non-pharmacological strategy delivered through Junior Public Health Nurses (JPHNs) in achieving and maintaining glycemic control among diabetic patients registered with NCD clinics of primary health care settings.Design: A cluster randomized controlled trial was conducted among adult patients with Diabetes Mellitus attending NCD clinics of primary care settings of South Kerala, India. JPHNs of the intervention group received additional module-based training while standard management continued in the control group. Sequence generation was done by random permuted blocks method and a cluster of 12 patients was selected from each of the 11 settings by computer-generated random numbers. Patients were followed up for 6 months with monthly monitoring of Fasting Blood Sugar (FBS), Post-Prandial Blood Sugar (PPBS), blood pressure, Body Mass Index (BMI), and health-related behaviors. Knowledge and skills/practice of JPHNs were also evaluated. Analysis of Covariance was done to study the final outcome adjusting for the baseline values and a model for glycemic control was predicted using multilevel modeling.Results: We analyzed 72 participants in the intervention group and 60 participants in the control group according to the intention-to-treat principle. The intervention was associated with a significant reduction in FBS (p &lt; 0.001) and PPBS (p &lt; 0.001) adjusting for the baseline values. The achievement of glycemic control was 1.5 (95% CI: 1.05–2.3) times better with intervention and they showed a better trend of maintenance of glycemic control (FBS, p = 0.003 and PPBS, p = 0.039). Adjusting for clustering and the baseline values, the intervention showed a significant effect on FBS (B = −3.1, SE = 0.57; p &lt; 0.001) and PPBS (B = −0.81, SE = 0.3; p &lt; 0.001) with time. Drug adherence score (p &lt; 0.001), hours of physical activity (p &lt; 0.001), BMI (p = 0.002), fruit intake (p = 0.004), and green leafy vegetable intake (p = 0.01) were the major predictors of FBS control. The practice/skills score of the JPHNs significantly improved with intervention (p &lt; 0.001) adjusting for baseline values.Conclusion: A well-designed health worker intervention package incorporated into the existing health system can translate into attitude change and skill development in the health workers which can reflect in the improvement of glycemic control among the patients.Trial registration: [URL: http://www.ctri.nic.in], identifier [CTRI/2017/11/010622].
Intravenous Tranexamic Acid Improves the Intraoperative Visualization of Endoscopic Sinus Surgery for High-Grade Chronic Rhinosinusitis: A Randomized, Controlled, Double-Blinded Prospective Trial
Authors: Yang Wenjing , Gou Haoling , Li He , Liu Ying , Wan Ying , Wang Chengshuo , Wang Guyan , Zhang Luo 
Published: November 2021

Objective: Intraoperative bleeding during endoscopic sinus surgery (ESS) for high-grade rhinosinusitis can be serious and can further obscure the surgical field. This study was designed to evaluate the effect of tranexamic acid (TXA) on the surgical visualization of ESS for high-grade rhinosinusitis.Methods: In total, 60 patients with high-grade chronic rhinosinusitis (Lund-Mackay score 12 or greater) treated by ESS were randomized into two groups: the control group (Group C) or the TXA group (Group T). Each group included 30 patients. Patients in Group T received intravenous TXA, and those in Group C received normal saline. The Boezaart grading scale (BS) score was assessed as the primary outcome. Total blood loss (TBL), whole blood coagulation, and fibrinolysis were assessed by Sonoclot analysis, and complications were recorded and compared between the groups.Result: A significant difference was found in the BS score between Group T and Group C [2.02 (1.88–2.05) vs. 2.27 (2.13–2.41), P = 0.011]. Increases in platelet function (PF) and fibrin degradation time (FDT) were assessed during the operation and showed significant differences between Group T and Group C (P = 0.040 for PF; P = 0.010 for FDT). No difference in complications was found between the two groups.Conclusion: A 15 mg/kg bolus of intravenous TXA before surgery can improve the surgical visualization of ESS for high-grade chronic rhinosinusitis without causing significant adverse effects. Intravenous TXA may be beneficial in ESS for high-grade chronic rhinosinusitis.Clinical Trial Registration:https://www.chictr.org.cn/edit.aspx?pid=121653&amp;htm=4.
HOẠT ĐỘ ENZYM GAMMA GLUTAMYL TRANSFERASE HUYẾT TƯƠNG Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG
Authors: Hoa Nguyễn Thị , Thu Vũ Thị Hoài 
Published: November 2021

Nghiên cứu nhằm xác định hoạt độ enzym GGT huyết tương ở bệnh nhân đái tháo đường type 2 và phân tích mối liên quan giữa hoạt độ enzym GGT huyết tương với một số yếu tố khác ở bệnh nhân đái tháo đường type 2. Bằng phương pháp nghiên cứu mô tả, cắt ngang trên 216 bệnh nhân đái tháo đường type 2 tại bệnh viện trường Đại học Y Dược Thái Nguyên, bệnh nhân được chia thành 2 nhóm: Nhóm 1 gồm 95 bệnh nhân đái tháo đường type 2 kiểm soát tốt nồng độ glucose; Nhóm 2 gồm 121 bệnh nhân đái tháo đường type 2 kiểm soát không tốt nồng độ glucose. Kết quả cho thấy, hoạt độ GGT huyết tương ở nhóm 1, nhóm 2 tương ứng là: 43,5±29,8 U/L, 56,2 ±33,6 U/L, p<0,001; Tỷ lệ tăng hoạt độ GGT huyết tương tương ứng là 34,7%; 64,5%, p<0,01. Có mối tương quan thuận mức độ vừa có ý nghĩa giữa GGT với nồng độ glucose, HbA1C và thời gian mắc bệnh. Tăng hoạt độ enzym GGT huyết tương ở bệnh nhân đái tháo đường, đặc biệt tăng cao hơn ở nhóm bệnh nhân đái tháo đường kiểm soát không tốt nồng độ glucose. Hoạt độ GGT huyết tương có xu hướng tăng theo nồng độ glucose, thời gian mắc bệnh cũng như theo chỉ số khối cơ thể.
Kualitas Hidup Ibu Hamil Selama Masa Pandemic Covid-19
Authors: Yuliani Meda 
Published: November 2021

Ibu hamil merupakan salah satu kelompok rentan, baik dalam kondisi hamil selama pandemic ataupun saat tidak pandemic. sehingga kondisi fisik dan psikologis ibu hamil perlu diketahui. selama pandemic ini ibu hamil dibatasi untuk melakukan pemeriksaan ke instansi kesehatan.Tujuan penelitian untuk mengetahui bagaimana kondisi kualitas hidup ibu hamil selama pandemic dengan mengkaji berdasarkan karakteristik ibu hamil dengan menggunakan instrument kualitas hidup dari WHO yaitu WHOQOL (Quality Of Life ), sehingga kualitas hidup dapat diketahui dari aspek fisik, psikis, social dan lingkungan ibu hamil selama pandemic. Metode dalam penelitian ini menggunakan deskriptif kuantitatif. Menggunakan rancangan penelitian cross sectional, Dengan tahap pengambilan data primer dengan menggunakan kuesioner kualitas hidup dari WHO yang sudah baku yaitu WHOQOL. Sampel dalam penelitian ini adalah seluruh ibu hamil yang datang ke Puskemas Cinunuk, dengan teknik pengambilan sampel menggunakan accidental sampling, dengan jumlah sampel sebanyak 123 ibu hamil. Data hasil penelitian menunjukan bahwa kualitas ibu hamil selama pandemic merasakan dalam kondisi fisik baik ( 62,6 %) dan kondisi kurang ( 4,9%), kondisi Psikologis merasa baik ( 62,6%) dan kondisi kurang (7,3%), kondisi sosial merasa baik ( 61,8%) dan kurang ( 7,3 %), kondisi lingkungan merasa baik ( 72,4%) dan cukup (20,3%). Penilaian kualitas hidup ibu hamil selama pandemic covid-19 ini memberikan gambaran situasi kondisi ibu hamil selama pandemic covid-19, meskipun didpatkan hasil kualitas hidup baik tetapi masih terdapat juga yang kualitas hidup kurang, sehingga diperlukan terus pemantauan kondisi kehamilan selama pandemic covid-19 ini baik dengan self control oleh ibu hamil itu sendiri ataupun self management oleh pihak tenaga kesehatan.
terapi slow deep breathing exerc PENGARUH TEKNIK RELAKSASI BENSON TERHADAP TINGKAT STRES PADA MAHASISWA TINGKAT AKHIR PROGRAM STUDI ILMU KEPERAWATAN FAKULTAS ILMU KESEHATAN UNIVERSITAS KADIRI
Authors: Ramayanti Eva Dwi 
Published: November 2021

Stres merupakan suatu kondisi dimana keadaan tubuh terganggu karena tekanan fisik maupun psikologis atau ketika individu merasa tidak sanggup mengatasi tuntutan yang dihadapinya. Stres mahasiswa dalam mengerjakan skripsi merupakan suatu keadaan mahasiswa yang mengalami ketidaksepadanan antara pekerjaan skripsi secara fisik maupun psikologis. Pada tahun 2015-2016 mahasiswa tingkat akhir Program Studi Ilmu Keperawatan Fakultas Ilmu Kesehatan Universitas Kadiri berjumlah 15 orang mengalami stres. Tujuan penelitian ini untuk mengetahui pengaruh teknik relaksasi benson terhadap stres pada mahasiswa tingkat akhir program studi ilmu keperawatan fakultas ilmu kesehatan universitas Kadiri tahun 2016. Rancangan penelitian ini adalah inferensial, penelitian lapangan, pre eksperimental, desain penelitian one group pre test pos test dan sumber data penelitian primer. Populasi dalam penelitian ini berjumlah 15 orang dan sampelnya semua total populasi. Variabel independen (X) adalah teknik relaksasi benson terhadap stres dan variabel dependent (Y) adalah mahasiswa tingkat akhir yang mengerjakan skripsi dengan menggunakan SOP dan lembaran observasi. Uji yang digunakan yaitu uji statistik Wilcoxon Sign Rank Test dengan α=0,05. Dari hasil penelitian sebelum diberikan teknik relaksasi benson sebagian besar mengalami stres sedang dan sesudah diberikan teknik relaksasi benson sebagian besar responden mengalami stres ringan. Berdasarkan uji statistik dengan Wilcoxon Sign Rank Test, diperoleh nilai p value (0,003) < dari nilai α (0,05), bahwa H0 ditolak dan H1 diterima. Dari hasil uji hipotesis dapat di simpulkan bahwa ada pengaruh teknik relaksasi benson terhadap stres pada mahasiswa tingkat akhir program studi ilmu keperawatan fakultas ilmu kesehatan universitas Kadiri Tahun 2016. Berdasarkan penelitian ini diharapkan lembaga pendidikan dapat memberikan fasilitasi dan terapi yang dapat menunjang kemampuan mahasiswa.
Hubungan Stres dengan siklus menstruasi
Authors: Handayani Trisna Yuni handayani Trisna 
Published: November 2021

Masa remaja merupakan masa transisi yang ditandai dengan perubahan fisik dan psikologis. Perubahan fisik dapat dilihat dari tanda-tanda seks primer dan sekunder. Pada remaja putri salah satunya adalah menstruasi. Sebagian remaja mengalami masalah dengan menstruasi diantaranya siklus menstruasi yang tidak teratur. Faktor yang menyebabkan terganggunya siklus menstruasi salah satunya adalah gangguan psikologis yaitu stres. Penelitian ini bertujuan untuk mengetahui hubungan stres dengan siklus menstruasi. Penelitian ini merupakan penelitian kuantitatif, jenis penelitian deskriptif analitik dengan pendekatan cross secsional. Teknik pengamblan sampel dengan simple random sampling. Sampel dalam penelitian ini adalah 42 mahasiswi kebidanan Institut Kesehatan Mitra. Penelitian ini menggunakan kuesioner dan untuk mengukur tingkat stress menggunakan DASS 42. Analisa data menggunakan chi square. Hasil analisis ada hubungan signifikan tingkat stress dengan siklus menstruasi Sig. (2- sided) adalah 0,015 yang berarti bahwa nilai (p<0,05). Remaja sebaiknya dapat melakukan mekanisme coping yang baik karena stres memiliki hubungan dengan siklus menstruasi.
Curricularização da extensão universitária: práticas de extensão realizadas no Curso de Letras - Língua Portuguesa durante a pandemia
Authors: Eckert Kleber , Fior Postingher Balzan Carina , Ogliari Mariani Priscila , Almeida de Lemos Aline , De Paula Guedes Esther , Ornes Bitencourt Junior Hamilton 
Published: November 2021

O presente trabalho busca relatar as experiências de extensão realizadas no componente curricular de “Estágio Supervisionado - Projetos de Extensão”, inserido no Curso de Licenciatura em Letras - Língua Portuguesa, no Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul campus Bento Gonçalves. As atividades realizadas envolveram planejamento e atuação em dois projetos de extensão do campus. O primeiro, a VI Semana de Língua e Literatura no campus, promoveu palestras, a respeito de temas vinculados ao ENEM e vestibulares, voltadas para a preparação dos alunos do Ensino Médio para essas provas. O segundo, o Curso de Português para imigrantes e refugiados, promoveu aulas de português para esse perfil de alunos, sob a perspectiva da Língua de Acolhimento. O objetivo deste relato é relacionar as práticas de extensão realizadas à proposta da curricularização da extensão, a fim de destacar a contribuição da extensão na formação dos sujeitos e na sociedade em que se insere e, portanto, a relevância da realização dessas atividades. Ainda, as ações de extensão aqui descritas foram realizadas em contexto pandêmico, portanto, também será objeto de reflexão o papel da extensão no sentido de mitigar os efeitos deletérios da pandemia da COVID-19 no ensino.
Aneurisma de la Vena Cava Superior
Authors: Santa Botero Daniel Catalina , Encizo Luisa Fernanda 
Published: November 2021

Síntomas progresivos inicalmente como disnea de levea a moderados esfuerzos 10 días previos a consulta que empeoraron con el reposo y que interrumpían las actividades diarias asociada a edemas de miembros inferiores y bipalpebral. Igualmente refería ortopnea y disnea paroxística nocturna sin tos o cianosis.
Un mes previo a su consulta inicial, la paciente inicia con placas eritematosas en ambas piernas acompañadas tanto de artralgias como astenia y eritema malar. Posteriormente se le confirmó el diagnóstico de lupus eritematoso sistémico.
Se le toma como imagen de valoración inicial, radiografía de tórax con imagen de masa a nivel de mediastino anterior por lo que se lleva a escanografía de tórax con contraste revelando imagen mostrada compatible con dilatación aneurismática de vena cava superior por lo que fue tratada inicialmente para cuadro de falla cardiaca y posteriormente se llevó con éxito a corrección quirúrgica.
Fachdidaktik Ernährung
Authors: Angele Claudia , Buchner Ursula , Michenthaler Johanna , Obermoser Susanne , Salzmann-Schojer Katharina 
Published: November 2021

Ernährungslehre kompetent unterrichten
Dieses Studienbuch für das Lehramt Sekundarstufe zeigt theoretisch-konzeptionelle Grundlagen fachdidaktischer Modelle, Prinzipien und Diskurse in den Handlungsfeldern des Lehrerberufs auf.
Authentische Fallbeispiele aus der Unterrichtspraxis, Studienaufgaben und Anregungen für die Unterrichtspraxis geben einen Einblick in zielgruppenspezifische Herangehensweisen. Es werden Ansatzpunkte und Desiderate für die fachdidaktische Forschung zum Lernen im Fachunterricht Ernährung sichtbar. Das Werk leistet somit einen wesentlichen Beitrag zur weiteren wissenschaftlichen Fundierung der Fachdidaktik Ernährung.
Das Studienbuch bietet Grundlagenwissen, das durch umfangreiche Studienaufgaben eigenständig vertieft werden kann. Es richtet sich an Studierende und Lehrende im Fach Ernährungslehre als auch an Interessierte aus der Praxis.
utb+: Leser:innen erhalten zum Buch als digitales Zusatzmaterial Beispiele aus der Unterrichtspraxis. 180 Anwendungsaufgaben regen zur vertiefenden Auseinandersetzung mit relevanten Kompetenzbereichen an.