bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra-High Temperature Thermal Conductivity Measurements of a Reactive Magnesium Manganese Oxide Porous Bed Using a Transient Hot Wire Method
Authors: Hayes Michael , Masoomi Faezeh , Schimmels Philipp , Randhir Kelvin , Klausner James , Petrasch Joerg 
Published: August 2021

Abstract
Pelletized magnesium manganese oxide shows promise for high temperature thermochemical energy storage. It can be thermally reduced in the temperature range between 1250 °C and 1500 °C and re-oxidized with air at typical gas-turbine inlet pressures (1–25 bar) in the temperature range between 600 °C and 1500 °C. The combined thermal and chemical volumetric energy density is approximately 2300 MJ/m3. The rate at which a thermochemical storage module can be charged is limited by heat transfer inside the solid packed bed. Hence, the effective thermal conductivity of packed beds of magnesium-manganese oxide pellets is a crucial parameter for engineering Mg-Mn-O redox storage devices. We have measured the effective thermal conductivity of a packed bed of 3.66 ± 0.516 mm sized magnesium manganese oxide (Mn to Mg molar ratio of 1:1) pellets in the temperature range of 300–1400 °C. Since the material is electrically conductive at temperatures above 600 °C, the sheathed transient hot wire method is used for measurements. Raw data is analyzed using the Blackwell solution to extract the bed thermal conductivity. The effective thermal conductivity standard deviation is less than 10% for a minimum of three repeat measurements at each temperature. Experimental results show an increase in the effective thermal conductivity with temperature from 0.50 W/m °C around 300 °C to 1.81 W/m °C close to 1400 °C. We propose a dual porosity model to express the effective thermal conductivity as a function of temperature. This model also considers the effect of radiation within the bed, as this is the dominant heat transfer mode at high temperatures. The proposed model accounts for microscale pellet porosity, macroscale bed porosity, pellet size, solid thermal conductivity (phonon transport), and radiation (photon transport). The coefficient of determination between the proposed model and the experimental results is greater than 0.90.
Improved Motor Proficiency and Quality of Life in Youth With Prader–Willi Syndrome and Obesity 6 Months After Completing a Parent-Led, Game-Based Intervention
Authors: Rubin Daniela A. , Wilson Kathleen S. , Tucker Jared M. , Castner Diobel M. , Dumont-Driscoll Marilyn C. , Rose Debra J. 
Published: August 2021

Purpose: To determine changes and potential differences in physical activity (PA), gross motor proficiency (MP), and health parameters after a 6-month follow-up (FU) period following participation in a parent-led PA intervention in youth with or without Prader–Willi syndrome (PWS). Methods: About 42 youth with PWS and 65 youth without PWS but with obesity (body fat percentage >95th percentile for age and sex), aged 8–16 years, participated. The intervention included preplanned PA sessions containing playground and console-based video games scheduled 4 days per week for 24 weeks. Families received training and curriculum materials. PA (accelerometry), MP (Bruininks–Oseretsky Test of MP), and health-related quality of life were obtained before (PRE), after completing the intervention (POST), and at FU. Results: There were no significant changes in PA at any time point. At FU and POST, participants showed higher bilateral coordination (PRE = 9.3 [0.4], POST = 11.7 [0.5], and FU = 11.1 [0.6]); speed and agility (PRE = 9.2 [0.4], POST = 10.8 [0.4], and FU = 11.5 [0.5]); and strength (PRE = 8.0 [0.3], POST = 9.2 [0.3], and FU = 9.2 [0.3]) than at PRE. At FU (80.3 [2.1]) and POST (79.8 [1.7]), youth without PWS showed higher health-related quality of life than PRE (75.0 [1.8]). Conclusion: The improvements in MP and health-related quality of life at FU suggest long-term durability of intervention outcomes.
High-Selectivity Polysiloxane Membranes for Gases and Liquids Separation (A Review)
Authors: Grushevenko E. A. , Borisov I. L. , Volkov A. V. 
Published: August 2021

Abstract
The most promising approaches to making polysiloxane-based membranes more selective are considered. These approaches can be subdivided into three groups: (1) development of new membrane materials by copolymerization, (2) modification of the polysiloxane chain (in the backbone and pendant chains), and (3) development of mixed matrix membranes. All the three approaches are subjected to a critical analysis, and conclusions are made on the prospects for the development of high-selectivity materials and high-performance membranes based on them. The data are presented from the viewpoint of applied aspects of polysiloxane-based membranes.
Feasibility and acceptability of a community pharmacy referral service for suspected lung cancer symptoms
Authors: Holland-Hart Daniella , McCutchan Grace M , Quinn-Scoggins Harriet Dorothy , Brain Kate , Hill Lucy , Shanbag Savita , Abel Michael , White Kelly , Evans Angela , Rees Sarah , Bowen Sarah , Gemine Rachel , Collier Gareth 
Published: August 2021

BackgroundLung cancer survival rates in the UK are among the lowest in Europe, principally due to late-stage diagnosis. Alternative routes to earlier diagnosis of lung cancer are needed in socioeconomically deprived communities that are disproportionately affected by poor lung cancer outcomes. We assessed the feasibility and acceptability of a community-based pharmacy referral service to encourage earlier symptomatic referral for chest X-rays.MethodsSeventeen community pharmacies located in a deprived area of Wales participated between March 2019 and March 2020. Stakeholder interviews were conducted with four patients, seven pharmacy professionals and one general practitioner. Four focus groups were conducted, including one with healthcare professionals (n=6) and three with members of the public who were current and former smokers (n=13). Quantitative data regarding patient characteristics and clinical outcomes were collected from hospital records and patient referral questionnaires completed by pharmacists and analysed using descriptive statistics. Qualitative data sets were analysed thematically and triangulated.ResultsTwelve patients used the pharmacy referral service, all of whom were male. Average length of the pharmacy consultation was 13 min, with a mean 3 days to accessing chest X-rays in secondary care. Patients experienced a mean 46-day wait for results, with no lung cancer detected. Participants found the service to be acceptable and considered the pharmacy element to be broadly feasible. Perceived barriers included low awareness of the service and concerns about the role and capacity of pharmacists to deliver the service. Facilitators included perceived approachability and accessibility of pharmacists. A well-publicised, multifaceted awareness campaign was recommended.ConclusionsA community pharmacy referral service for lung symptoms was considered an acceptable alternative pathway to symptomatic diagnosis of lung cancer in deprived communities. Wider implementation of the service would require workforce capacity and training to be addressed to ensure optimum utilisation and promotion of the service.
Risk factors and outcomes of unrecognised endobronchial intubation in major trauma patients
Authors: Heyne Guido , Ewens Sebastian , Kirsten Holger , Fakler Johannes Karl Maria , Özkurtul Orkun , Hempel Gunther , Krämer Sebastian , Struck Manuel Florian 
Published: August 2021

BackgroundEmergency tracheal intubation during major trauma resuscitation may be associated with unrecognised endobronchial intubation. The risk factors and outcomes associated with this issue have not previously been fully defined.MethodsWe retrospectively analysed adult patients admitted directly from the scene to the ED of a single level 1 trauma centre, who received either prehospital or ED tracheal intubation prior to initial whole-body CT from January 2008 to December 2019. Our objectives were to describe tube-to-carina distances (TCDs) via CT and to assess the risk factors and outcomes (mortality, length of intensive care unit stay and mechanical ventilation) of patients with endobronchial intubation (TCD <0 cm) using a multivariable model.ResultsWe included 616 patients and discovered 26 (4.2%) cases of endobronchial intubation identified on CT. Factors associated with an increased risk of endobronchial intubations were short body height (OR per 1 cm increase 0.89; 95% CI 0.84 to 0.94; p≤0.001), a high body mass index (OR 1.14; 95% CI 1.04 to 1.25; p=0.005) and ED intubation (OR 3.62; 95% CI 1.39 to 8.90; p=0.006). Eight of 26 cases underwent tube thoracostomy, four of whom had no evidence of underlying chest injury on CT. There was no statistically significant difference in mortality or length of stay although the absolute number of endobronchial intubations was small.ConclusionsShort body height and high body mass index were associated with endobronchial intubation. Before considering tube thoracostomy in intubated major trauma patients suspected of pneumothorax, the possibility of unrecognised endobronchial intubation should be considered.
Application of Lyon Consensus criteria for GORD diagnosis: evaluation of conventional and new impedance-pH parameters
Authors: Frazzoni Leonardo , Frazzoni Marzio , De Bortoli Nicola , Ribolsi Mentore , Tolone Salvatore , Russo Salvatore , Conigliaro Rita Luisa , Penagini Roberto , Fuccio Lorenzo , Zagari Rocco Maurizio , Savarino Edoardo 
Published: August 2021

ObjectiveTo validate Lyon Consensus criteria for diagnosing gastro-oesophageal reflux disease (GORD) by reflux monitoring.DesignManual review of impedance-pH tracings from patients with proton pump inhibitor (PPI)-dependent heartburn, evaluated off PPI. Acid exposure time (AET) thresholds defined by the Lyon Consensus and impedance parameters were investigated, namely, total refluxes (TRs), postreflux swallow-induced peristaltic wave (PSPW) index and mean nocturnal baseline impedance (MNBI).ResultsThe study included 488 patients, 178 (36%) with normal (<4%) AET, 89 (18%) with inconclusive (4%–6%) AET and 221 (45%) with abnormal (>6%) AET, alongside with 70 healthy controls. At receiver operating characteristic analysis, area under curve was 0.89, 0.95 and 0.89 for TRs, PSPW index and MNBI, respectively, and threshold values were 40, 50% and 2000 Ω; the 4% physiological AET threshold defined by the Lyon Consensus showed 100% specificity but 63% sensitivity. The thresholds defined for impedance parameters were validated against AET by means of ordered logistic regression, being in concordance with the 4% AET threshold (OR 2.5 for TRs, 18.9 for PSPW index and 5.7 for MNBI). TRs positivity and concordant PSPW index/MNBI positivity were found in 80%–90% of patients in the abnormal AET group, in 73%–74% of cases in the inconclusive AET group and in 28%–40% of cases in the group with normal AET.ConclusionsOur results show the overall validity of the Lyon Consensus approach to GORD diagnosis. Adding evaluation of impedance parameters, namely, TRs, PSPW index and MNBI to AET appraisal, substantially improves the diagnostic yield of reflux monitoring.
Malignant pleural mesothelioma with heterologous elements
Authors: Kawai Toshiaki , Seki Reishi , Miyajima Kuniharu , Nakashima Hiroshi , Takeda Takayuki , Murakami Tomoyuki , Aoe Keisuke , Okabe Kazunori , Homma Keiichi , Tsukamoto Yoshitane , Sunada Koichi , Terasaki Yasuhiro , Iida Maki , Orikasa Hideki , Hiroshima Kenzo 
Published: August 2021

AimsMalignant pleural mesothelioma with heterologous elements (such as osseous, cartilaginous or rhabdomyoblastic differentiation) is very rare. We tried to differentiate such mesothelioma cases from extraskeletal pleural osteosarcoma, which is very challenging.MethodsWe compared 10 malignant pleural mesotheliomas (three biphasic and seven sarcomatoid types) with two pleural osteosarcomas using clinicopathological and immunohistochemical methods, and also fluorescence in situ hybridisation (FISH) to examine for homozygous deletion of p16.ResultsThe median age was 72 years for mesotheliomas, and 69 years for osteosarcoma. For mesothelioma, eight cases were male and two were female. Growth was diffuse in all mesothelioma cases except case 10, where it was localised, as it was for the two osteosarcomas. Among mesothelioma cases, 80% displayed osteosarcomatous and 60% chondromatous elements, while 10% exhibited rhabdomyoblastic ones. Immunohistochemical labelling for calretinin and AE1/AE3 was present in 8/10 and 7/10 mesotheliomas, respectively, but in only one osteosarcoma. Loss of methylthioadenosine phosphorylase was seen in 5/7 mesotheliomas. FISH analysis revealed homozygous deletion of p16 in 5/8 mesothelioma and 2/2 osteosarcoma. Median survival was 6.5 months after biopsy or surgical operation in mesothelioma, and 12 months after operation in osteosarcoma.ConclusionsAlthough median survival was longer for osteosarcoma than for malignant mesothelioma, we could not differentiate mesothelioma from pleural osteosarcoma on the combined basis of clinicopathological and immunohistochemical data, and FISH analysis. However, diffuse growth was more frequent in mesothelioma than in osteosarcoma.
High-risk human papillomavirus (HPV) detection in formalin-fixed paraffin-embedded cervical tissues: performances of Aptima HPV assay and Beckton Dickinson (BD) Onclarity assay
Authors: Kir Gozde , Gunel Humeyra , Olgun Zeynep Cagla , McCluggage W Glenn 
Published: August 2021

AimThere are many scenarios where high-risk human papillomavirus (HPV) detection in formalin-fixed paraffin-embedded (FFPE) specimens is important. However, there is no Food and Drug Administration (FDA)-approved and clinically validated technique for detecting high-risk HPV in FFPE tissues. In this study, we evaluated two commercially available HPV assays which are FDA-approved for use on cytology specimens, the Aptima HPV assay and the Beckton Dickinson (BD) Onclarity assay, to detect high-risk HPV in FFPE tissues of cervical high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma (SCC).MethodsA total of 189 cases (46 SCC, 107 HSIL and 36 benign/normal) were tested for high-risk HPV with the Aptima HPV assay and a subset of cases (n=97) with the BD Onclarity assay.ResultsThe sensitivities of the Aptima and BD Onclarity HPV assays were 99.4% (95% CI 96.46% to 99.98%) and 75.9% (95% CI 65.27% to 84.62%), respectively; the specificity and positive predictive value (PPV) of the two assays were 100%. Negative predictive values of the Aptima and BD Onclarity HPV assays were 97.3% (95% CI 83.61% to 99.61%) and 67.7% (95% CI 58.91% to 75.47%), respectively. The kappa value (0.96) for comparison of the distribution of high-risk HPV types between the two assays was high. HPV 16 was the most common high-risk HPV type for HSIL and SCC cases. However, SCC cases had higher percentages of HPV 16 and HPV 18/45 and lower percentages of other high-risk HPV types compared with HSIL cases.ConclusionBoth assays are reliable methods for high-risk HPV detection and genotype determination in FFPE specimens, with high PPV and specificity. The Aptima HPV assay has the advantage of higher sensitivity. As far as we are aware, this is the first study comparing the Aptima HPV assay and the BD Onclarity assay in FFPE tissues. Our study results should be tested and confirmed in larger cohorts.
Tobacco industry pricing strategies in response to excise tax policies: a systematic review
Authors: Sheikh Zaineb Danish , Branston J Robert , Gilmore Anna B 
Published: August 2021

ObjectiveTo explore what is known about the tobacco industry’s (TI) price-based responses to tobacco excise tax policies and whether these vary by country income group using a systematic review.Data sourcesStudies assessing TI pricing tactics were identified via searches of five online databases using a combination of search keywords.Study selectionInclusion criteria were applied by two reviewers independently who screened all search results (titles and abstracts) for possible inclusion. They identified 37 publications that reported TI pricing tactics.Data extractionStudy details were tabulated, and information was extracted on the country income group, population characteristics, excise tax structure, and pricing strategies.Data synthesisOf the 37 publications identified, 22 were conducted in high-income countries, while 15 covered low-income and middle-income countries (LMICs). Major pricing strategies employed were: differentially shifting taxes between products (35 studies); launching new brands/products as pathways for downtrading (six studies), product promotions and different prices for the same products for different customers (six studies); price smoothing (two studies); and changing product attributes such as length/size of cigarettes or production processes (three studies).ConclusionsWhile there is limited evidence to fully ascertain industry responses to tax increases, this review suggests that the TI widely uses a multitude of sophisticated pricing strategies across different settings around the world with the intention of undermining tax policies, thereby increasing tobacco consumption and maximising their profits. There is a need for further research in this area especially in LMICs so that effective policy responses can be developed.
Liquid intrusion in and extrusion from non-wettable nanopores for technological applications
Authors: Giacomello Alberto , Casciola Carlo Massimo , Grosu Yaroslav , Meloni Simone 
Published: August 2021

AbstractIn this article, we review some recent theoretical results about intrusion and extrusion of non-wetting liquids in and out of cavities of nanotextured surfaces and nanoporous materials. Nanoscale confinement allows these processes to happen at conditions which significantly differ from bulk phase coexistence. In particular, the pressure at which a liquid penetrates in and exits from cavities is of interest for many technological applications such as energy storage, dissipation, and conversion, materials with negative compressibility, ion channels, liquid chromatography, and more. Notwithstanding its technological interest, intrusion/extrusion processes are difficult to understand and control solely via experiments: the missing step is often a simple theory capable of providing a microscopic interpretation of the results, e.g., of liquid porosimetry or other techniques used in the field, especially in the case of complex nanoporous media. In this context, simulations can help shedding light on the relation between the morphology of pores, the chemical composition of the solids and liquids, and the thermodynamics and kinetics of intrusion and extrusion. Indeed, the intrusion/extrusion kinetics is determined by the presence of free energy barriers and special approaches, the so-called rare event techniques, must be used to study these processes. Usually, rare event techniques are employed to investigate processes occurring in relatively simple molecular systems, while intrusion/extrusion concerns the collective dynamics of hundreds to thousands of degrees of freedom, the molecules of a liquid entering in or exiting from a cavity, which, from the methodological point of view, is itself a challenge.
Background identification in cryogenic calorimeters through $$\alpha -\alpha $$ delayed coincidences
Authors: Azzolini O. , Beeman J. W. , Bellini F. , Beretta M. , Biassoni M. , Brofferio C. , Bucci C. , Capelli S. , Cardani L. , Carniti P. , Casali N. , Chiesa D. , Clemenza M. , Cremonesi O. , Cruciani A. , Dafinei I. , D’Addabbo A. , Di Domizio S. , Ferroni F. , Gironi L. , Giuliani A. , Gorla P. , Gotti C. , Keppel G. , Martinez M. , Nagorny S. , Nastasi M. , Nisi S. , Nones C. , Orlandi D. , Pagnanini L. , Pallavicini M. , Pattavina L. , Pavan M. , Pessina G. , Pettinacci V. , Pirro S. , Pozzi S. , Previtali E. , Puiu A. , Rusconi C. , Schäffner K. , Tomei C. , Vignati M. , Zolotarova A. 
Published: August 2021

AbstractLocalization and modeling of radioactive contaminations is a challenge that ultra-low background experiments are constantly facing. These are fundamental steps both to extract scientific results and to further reduce the background of the detectors. Here we present an innovative technique based on the analysis of $$\alpha -\alpha $$

α
-
α

delayed coincidences in $${}^{232}$$

232

Th and $${}^{238}$$

238

U decay chains, developed to investigate the contaminations of the ZnSe crystals in the CUPID-0 experiment. This method allows to disentangle surface and bulk contaminations of the detectors relying on the different probability to tag delayed coincidences as function of the $$\alpha $$
α
decay position.
Analytical simulation of nanoparticle-embedded blood flow control with magnetic field influence through spectra homotopy analysis method
Authors: Ige Ebenezer Olubunmi , Oyelami Funmilayo Helen , Adedipe Emmanuel Segun , Tlili Iskander , Khan M. Ijaz , Khan Sami Ullah , Malik M. Y. , Xia Wei-Feng 
Published: August 2021

Nanoparticles-based infusion strategies are presently being employed for a range of clinical interventions either for in vivo or in vitro applications while imposition of magnetic field is also identified as an important technique for fluid manipulation during nanoparticles-based propulsion. The impact of magnetic field to control of the transport of nanoparticles-based blood flow is demonstrated numerically over an elaborate variant of transport mechanisms. Mathematical formulations were undertaken and stability analysis of the mathematical problem was a scrutinized by generation of eigen values using the Lyapunov scheme. The numerical solution based on Chebysehev pseudo-spectra and spectra homotopy analysis method (SHAM) was implemented to handle the combination on nonlinear ordinary differential equations derived from the transport models. We observed that far-field of the stagnation point, nanoparticles specie dispersion increased with higher thermal diffusivity, while the decrease in concentration profile around the vicinity of stagnation point depicts clustering of nanoparticles-embedded blood flow. The observations revealed that higher magnitude of thermophoretic parameters constitute significantly to increase in momentum as well as energy fields during transport of nanoparticles-containing blood flow under magnetic field influence. These findings showed the potentials of magnetic-field for control of suspended particles in transport medium which could be harnessed to manipulate transport of nanoparticles-containing fluids in microfluidic platforms with intricate configurations.