bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incremental value of feature-tracking cardiac magnetic resonance imaging in detecting myocardial dysfunction in patients with idiopathic ventricular arrhythmias
Authors: Nikolaidou C , Kotanidis C , Leal-Pelado J , Kouskouras K , Vassilikos VP , Karvounis H , Karamitsos TD 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Cardiac magnetic resonance (CMR) imaging can identify the underlying substrate in patients with ventricular arrhythmias (VAs) and normal echocardiography. Myocardial strain has emerged as a superior index of systolic performance compared to ejection fraction (EF), with an incremental prognostic value in many cardiac diseases.

Purpose
To assess myocardial deformation using 2-D feature-tracking CMR strain imaging (CMR-FT) in patients with frequent VAs (≥500 ventricular premature contractions (VPC)/24 hours; and/or non-sustained ventricular tachycardia), and structurally normal hearts on echocardiography without evidence of coronary artery disease.

Methods
Sixty-eight consecutive patients (mean age 46 ± 16 years; 54% female) and 72 healthy controls matched for age and body surface area were included in the study. CMR imaging was performed on a 1.5T Magnetom Avanto (Siemens, Erlangen, Germany) scanner using a standard cardiac protocol.

Results
CMR showed normal findings in 30 patients (44%), while 16 (24%) had previous myocarditis, 6 (9%) had a diagnosis of non-ischaemic cardiomyopathy (NICM), 15 (22%) were diagnosed with VPC-related cardiomyopathy, and 1 patient had subendocardial infarction [excluded from strain analysis]. Mean left ventricular EF (LVEF) in patients was 62% ± 6% and right ventricular EF 64% ± 6% (vs. 65% ± 3% and 66% ± 4% in controls, respectively). Compared to control subjects, patients with VAs had impaired peak LV global radial strain (GRS) (28.88% [IQR: 25.87% to 33.97%] vs. 36.65% [IQR:33.19% to 40.2%], p &lt; 0.001) and global circumferential strain (GCS) (-17.73% [IQR: -19.8% to -16.33%] vs. -20.66% [IQR: -21.72% to -19.6%], p &lt; 0.001, Panel A). Peak LV GRS could differentiate patients with previous myocarditis from patients with NICM and those with VPC-related cardiomyopathy (Panel B). Peak LV GCS could differentiate patients with previous myocarditis from patients with NICM (Panel C). Peak LV GRS showed excellent diagnostic accuracy in detecting patients from control subjects (Panel D). In a multivariable regression model, subjects with a low GRS (&lt;29.91%-determined by the Youden’s index) had 5-fold higher odds of having VAs (OR:4.99 [95%CI: 1.2-21.95]), after adjusting for LVEF, LV end-diastolic volume index, age, sex, BMI, smoking, hypertension, and dyslipidaemia. Peak LV global longitudinal strain (GLS) and RV strain indices were not statistically different between patients and controls.

Conclusion
Peak LV GRS and GCS are impaired in patients with frequent idiopathic VAs and can detect myocardial contractile dysfunction in patients with different underlying substrates. Our findings suggest that LV strain indices on CMR-FT constitute independent markers of myocardial dysfunction on top and independently of EF.
Abstract Figure.
Misalignment of hemodynamic forces in the left ventricle is associated with adverse remodeling following STEMI
Authors: Filomena D , Cimino S , Monosilio S , Birtolo LI , Galea N , Francone M , Mancuso G , Riccio F , Pierucci N , Pedrizzetti G , Tonti G , Fedele F , Maestrini V , Agati L 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Infarct size (IS), area at risk (AAR) and microvascular obstruction (MVO) are well known predictors of adverse remodeling (aLVr) following acute myocardial infarction, while the pathogenic role of left ventricular (LV) hemodynamic forces (HDFs) is still unknown. Recent evidence suggests the role of HDFs in negative remodeling after pathogenic events.

Purpose
To identify LV HDFs patterns associated with aLVr in reperfused ST-segment elevation MI (STEMI) patients.

Methods
Forty-nine acute STEMI patients underwent CMR at 1 week (baseline) and 4 months (follow-up) after MI. The following parameters were measured: left ventricular end-diastolic and end-systolic volume index for body surface area (LVEDVi and LVESVi), left ventricular ejection fraction (LVEF) and LV mass index, AAR and IS. LV HDFs were computed at baseline from cine CMR long axis datasets using a novel method based on LV endocardial boundary tracking. LV HDFs were calculated both in apex-base (A-B) and latero-septal (L-S) directions. The distribution of LV HDFs were evaluated by L-S over A-B HDFs ratio (L-S/A-B HDFs ratio %). All HDFs parameters are computed over the entire heartbeat, in systole and diastole. aLVr was defined as an absolute increase in LVESV of at least 15% (ΔLV-ESV ≥15%).

Results
Patients with aLVr (n = 18; 37%) had significant greater value of AAR (32 ± 23 vs 22 ± 18; p = 0.03) and slightly larger IS (23 ± 16 vs 15 ± 11; p= 0.07) at baseline. In patients with aLVr at FU, baseline systolic L-S HDF were lower (2.7 ± 0.9 vs 3.6 ± 1; p = 0.027) while diastolic L-S/A-B HDF ratio was significantly higher (28 ± 14 vs 19 ± 6; p = 0.03), reflecting higher grade of diastolic HDFs misalignment. At univariate logistic regression analysis, higher IS [Odd ratio (OR) 1.05; 95% confidence interval (95% CI) 1.01-1.1; p= 0.04] L-S HDFs (OR 0.41; 95% CI 0.2-0.9; p= 0.04] and higher diastolic L-S/A-B HDFs ratio (OR 1.1; 95% CI 1.01-1.2; p= 0.05) were associated with aLVr at FU (Table). At multivariate logistic regression analysis, L-S/A-B HDF ratio remained the only independent predictor of adverse LV remodeling after correction for other baseline determinants.

Conclusion
Misalignment of diastolic HDFs following STEMI is associated with aLVr observed after 4 months.
Predictors of adverse remodeling Univariate Multivariate Parameter OR (95% CI) P OR (95% CI) P IS (%) 1.05 (1.01-1.1) 0.042 - - Systolic L-S HDF 0.41 (0.2-0.9) 0.04 - - Diastolic L-S/A-B HDF Ratio 1.1 (1.01-1.2) 0.05 1.1 (1.01-1.2) 0.04 A-B:apex-base; L-S: latero-septal; HDFs: hemodynamic forces Abstract Figure. Diastolic HDFs distribution and aLVr
CMR 4D flow underestimates peak systolic flow measurements in patients with severe aortic stenosis
Authors: Halva R , Peltonen J , Kaasalainen T , Lommi J , Suihko S , Kylmala M , Kivisto S , Holmstrom M , Vaara SM , Syvaranta S 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public hospital(s). Main funding source(s): Helsinki University Hospital, Finland

Background
Aortic stenosis (AS) is the most prevalent valvular disease in the developed countries. 4D flow is an emerging cardiac magnetic resonance (CMR) imaging technique, which has been suggested to improve the evaluation of AS severity. The accuracy of peak flow measurement by 4D flow CMR in patients with severe AS has, however, remained unvalidated.

Purpose
We investigated the reliability of the novel 4D flow CMR technique in measuring transvalvular peak systolic flow in patients with severe aortic valve stenosis.

Methods
The study included 63 patients clinically evaluated for valve replacement due to severe symptomatic AS. All the patients underwent echocardiography, 2D phase-contrast and 4D flow CMR. CMR was performed on consecutive patients according to international guidelines. Mean age of the patients was 73.8 ± 11.5 years, mean aortic valve area 0.7 ± 0.2 cm², and 40 of the valves were tricuspid and 23 bicuspid. QFlow and QFlow 4D software were used for flow analyses. Bland-Altman analyses and Wilcoxon signed rank sum tests were performed using SPSS software.

Results
CMR 4D flow analyses underestimated peak flow values when compared with echocardiography (bias -1.1 m/s, limits of agreement ± 1.5 m/s) and with 2D flow analyses (bias -1.2 m/s, limits of agreement ± 1.7 m/s). The difference between values obtained by 4D flow (median 3.1 m/s, range 1.5 – 4.9 m/s) and echocardiography (median 4.3 m/s, range 2.1 – 6.1 m/s) as well as by 2D flow (median 4.3 m/s, range 2.0 – 8.4 m/s) were statistically significant (p &lt; 0,001). The difference between 2D flow analyses and echocardiography remained statistically insignificant (bias 0.05 m/s, limits of agreement ± 1.6 m/s).

Conclusions
We found that 4D flow analysis significantly underestimates systolic peak flow values in patients with severe AS. This may be due to intra-voxel averaging of the narrow jets. In contrast to previous assumptions, traditional 2D flow technique may therefore outperform 4D flow in measuring valvular peak flow by CMR in patients with severe AS. This should be taken into consideration when assessing disease severity by CMR.
Abstract Figure. Peak systolic flow in AS patients (n = 63)
Vasodilatation stress cardiovascular magnetic resonance: feasibility and safety in a monocentric prospective study
Authors: Pezel T , Garot P , Hovasse T , Toupin S , Unterseeh T , Morice MC , Champagne S , Louvard Y , Sanguineti F , Garot J 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

BACKGROUND
Cardiovascular magnetic resonance imaging (CMR) has emerged as an accurate technique that can assess ventricular function, stress myocardial perfusion, and viability, without radiation. Recent studies have shown that stress CMR would be the best test to predict obstructive coronary artery disease (CAD) with a good safety.

PURPOSE
The aim of our study was to assess the feasibility and incidence of immediate complications of stress CMR in a tertiary Cardiovascular Center with CMR Laboratory dedicated.

METHODS
Prospective registry of vasodilator stress CMR in a French center with CMR expertise included all consecutive patients referred for vasodilator stress perfusion CMR to detect an obstructive CAD between 2008 and 2020. Stress CMR was performed at 1.5 T using dipyridamole. The clinical and demographic data, quality of test, CMR findings, haemodynamic data, and complications were prospectively recorded.

RESULTS
Stress CMR was performed in 35,157 patients (98.2% of requested). The study could not be performed due to claustrophobia in 0.3%. Quality was optimal in 93.1%, suboptimal in 6.4%, and poor in 0.5% of studies. Images were diagnostic in 97.9% of patients. No patient died or had acute myocardial infarction during the test. Moreover, 56 patients (0.16%) had severe immediate complications, and one anaphylactic shock post-gadolinium. The only factor significantly associated with higher incidence of serious complications was the detection of inducible ischaemia (p &lt; 0.001). Incidence of non-severe complications was low (1.5%), severe controlled chest pain being the most frequent. Minor symptoms occurred frequently (35.5%).

CONCLUSION
Performance of stress CMR is safe with very high image rate of satisfactory quality to perform the diagnosis in a referral population. Inducible ischaemia was the only factor identified which was associated with serious complications.
Abstract Table. Final results after stress CMR
Hyperventilation-breath-hold maneuver to detect ischemia by strain-encoded CMR: a pilot study to evaluate a needle-free stress protocol
Authors: Kajzar I , Ochs MM , Salatzki J , Ochs AT , Riffel J , Osman N , Katus HA , Friedrich MG 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Safety concerns for gadolinium-containing contrast agents and pharmacological stressors, together with tremendous costs and inconsistent reimbursement modalities are still limiting a widespread application of CMR stress testing despite proven benefits. Like the effect of adenosine, hyperventilation-breath-hold-maneuver (HVBH) has demonstrated to induce myocardial vasodilation and might serve as a stressor to induce coronary steal with consecutive hypokinesia.

Purpose
To evaluate the diagnostic accuracy of a needle-free, ultrafast stress test to detect myocardial ischemia by strain-encoded CMR (fSENC) after HVBH.

Methods
Patients referred for CMR stress testing underwent an extended protocol in order to evaluate three different stress forms: (1) Adenosine first-pass perfusion (Ad-FPP), (2) Adenosine-fSENC (Ad-fSENC) and (3) HVBH-fSENC. Diagnostic accuracy was assessed using quantitative coronary angiography as reference.

Results
One-hundred-twenty-two predominantly male patients (age 66 ± 11years; 80% men) suspected for obstructive CAD were enrolled. Ad-fSENC and HVBH-fSENC provided significantly better diagnostic accuracy than Ad-FPP, both on a patient-level (Ad-fSENC: sensitivity 82%[65-93], specificity 83%[73-90], p &lt; 0.05; HVBH-fSENC: sensitivity 81%[64-93], specificity 86%[77-93], p &lt; 0.05) and territory-level (Ad-fSENC: sensitivity 67%[52-80], specificity 93%[90-96], p &lt; 0.05; HVBH-fSENC: sensitivity 63%[47-76], specificity 95%[91-97], p &lt; 0.05). The stress response of longitudinal strain differs significantly between ischemic and non-ischemic segments to Adenosine (LSischemic = 0.6 ± 5.4%, LSnon-ischemic = 0.9 ± 2.7%, p &lt; 0.05) and HVBH (LSischemic = 1.3 ± 3.8%, LSnon-ischemic=-0.3 ± 1.8%, p = 0.002). Stress test duration of HVBH-fSENC (t = 64 ± 2s) was significantly shortened compared to Ad-fSENC (t = 184 ± 59s, p &lt; 0.0001) or Ad-FPP (t = Ad-FPP: 172 ± 59s, p &lt; 0.0001).

Conclusions
Stress testing by HVBH-fSENC provides promising diagnostic accuracy to detect myocardial ischemia and is faster than established methods without the necessity to apply contrast agent or pharmacological stressors.
Long term outcomes in left ventricular noncompaction
Authors: Casas G , Limeres J , Oristrell G , Gutierrez L , Barriales R , Garcia-Pavia P , Zorio E , Gimeno JR , Villacorta E , Jimenez-Jaimez J , Ripoll T , Bayes A , Ferreira I , Rodriguez-Palomares JF 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Left ventricular noncompaction (LVNC) is a heterogeneous entity with a wide phenotypic expression. Risk factors have not been well established and prognostic stratification remains challenging.

Objectives
Describe long term outcomes of LVNC patients and determine predictors of cardiovascular events.

Methods

Prospective multicentric study of consecutive patients fulfilling imaging diangostic criteria for LVNC (Jenni echo criteria and Petersen CMR criteria). Demographic, ECG, imaging and genetic variables were collected. End points were heart failure (HF), ventricular arrhythmias (VA), systemic embolisms (SE) and all-cause death. Major adverse cardiovascular events (MACE) was the combination of the four previous end points.

Results
585 patients from 12 referral centres were included from 2000 to 2018. Age at diagnosis was 45 ± 20 years, 334 (57%) were male, baseline LVEF was 48 ± 17% and 18% presented late gadolinium enhancement (LGE). During a median follow-up of 5.1 years (IQR 2.3-8.1), 110 (19%) patients presented HF, 87 (15%) VA, 18 (3%) SE and 34 (6%) died. MACE occurred in 223 (38%) patients.
LVEF was independently associated with HF, VA, SE and MACE: HR were 1.08, 1.02, 1.04 and 1.02 respectively (all p &lt; 0.05). LGE was more frequent in patients with reduced LVEF (39 Vs 53%, p &lt; 0.001) and was associated with higher HF and VA risk in patients with LVEF &gt; 35% (HR 2.69 and 2.48 respectively, p &lt; 0.05) (Figure 1). Patients with a normal ECG, LVEF≥50%, no LGE and no family aggregation presented no MACE (0%) at long term follow-up.
Among patients who underwent genetic testing (354, 61%), TTN variants and complex genotype (more than one variant) presented lower LVEF and higher HF risk. ACTC1 variants were associated with VA.

Conclusions
LVNC carries a high long term risk of heart faliure and ventricular arrhythmias. LVEF is the most important predictor and myocardial fibrosis is associated with increased risk in patients without severe systolic dysfunction. Genotype is a modifier of outcomes. These factors might be used to risk stratify LVNC patients.
Abstract Figure. Kaplan Meier survival curves
Myocardial extracellular space expansion is related to burden of premature ventricular contractions in patients with hypertrophic cardiomyopathy without non-sustained ventricular tachycardia
Authors: Chung H , Park CH , Kim YJ , Kim JY , Min PK , Yoon YW , Lee KA , Lee BK , Hong BK , Kim TH , Rim SJ , Kwon HM , Choi EY 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Current guidelines suggest the presence of non-sustained ventricular tachycardia (NSVT) as a risk factor of sudden cardiac death in patients with hypertrophic cardiomyopathy (HCM). However, high burden of premature ventricular contraction (PVC) may reflect myocardial fibrosis although the absence of NSVT.

Purpose
We investigated the association between PVC burden and myocardial extracellular space expansion in HCM patients without NSVT.

Methods
Of the 212 patients prospectively enrolled to the HCM registry of genetics, 84 patients were evaluated with both cardiac magnetic resonance and 24hr holter. Among them, 71 patients (58 males, mean age: 71 ± 13 years) have not been diagnosed with NSVT.

Results
Patients with NSVT (n = 13) showed more impaired LA functional indices and higher myocardial fibrosis burden compared with patients without NSVT (n = 71). Among patients who have not been diagnosed with NSVT, patients with late gadolinium enhancement (LGE, n = 46) had a higher total beats (109 ± 332 vs. 7 ± 13 beats per a day, p = 0.003) and burden (0.114 ± 0.225 vs. 0.008 ± 0.014 %, p = 0.003) of PVC during 24-hour compared with patients without LGE (n = 25). %LGE was correlated with total beats of PVC (r = 0.358, p = 0.002) and PVC burden (r = 0.377, p = 0.001). ECV also correlated with total beats of PVC (r = 0.387, p = 0.001) and PVC burden (r = 0.401, p = 0.001). The optimal cutoff value for PVC number was 45 (37.0% of sensitivity and 100% of specificity) with 0.733 of the area under the ROC curve (p &lt; 0.001). Pathogenic or likely pathogenic sarcomere mutation was higher in NSVT group than no NSVT group (p &lt; 0.05), and had a higher tendency in higher PVC burden group (0.05 &lt; p &lt; 0.1) than lower PVC burden group.

Conclusions
Total beats and burden of PVC are significantly related to increase in myocardial fibrosis in HCM patients without NSVT.
Abstract Figure. Mechanism of ventricular arrhythmia
What if HCM Risk-SCD was assessed with CMR maximum LV wall thickness measurements?
Authors: Neto A , Oliveira I , Cruz I , Seabra D , Pontes Dos Santos R , Andrade A , Azevedo J , Pinto P 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
The HCM Risk-SCD estimates the risk of sudden cardiac death at 5 years in patients (pts) with hypertrophic cardiomyopathy (HCM). According to ESC Guidelines, in pts with a 5-year risk of SCD &lt;4%, an implantable cardioverter defibrillator (ICD) is generally not indicated, in pts with a risk of 4 to less than 6%, an ICD may be considered and in pts with a 5-year risk ≥6%, an ICD should be considered. The association between the degree of LVH and sudden cardiac death (SCD) has been based on measurements of maximum LVWT by echocardiography which is part of HCM Risk-SCD score. However, cardiac magnetic resonance (CMR) has shown a superior resolution in characterization of cardiac structures, with additional role in SCD risk stratification. Whether measurements of LVWT by echocardiography and CMR are interchangeable has been brought to question.

Purpose
We sought to evaluate the incidence of discrepant measurements of maximal LVWT between echocardiography and CMR and determine its implication in HCM Risk-SCD score and ICD indication.

Methods
Unicentric, retrospective analysis of pts submitted to CMR who had HCM as definitive diagnosis, between 1/2013 and 9/2019. CMR and echocardiographic measures were compared, as well as HCM Risk-SCD score calculated with these values (maximum LVWT was the only variable that differed between measures). Subsequently, pts were divided in three groups according to HCM Risk-SCD score: pts with a 5-year risk of SCD &lt;4% (G1), risk of 4 to less than 6% (G2) and risk ≥6% (G3).

Results
Out of the 781 CMR studies evaluated, 59 pts were found to have HCM (7.6%) with mean age of 62 ± 11 years and female predominance (50.8%). 12 pts had obstructive phenotype (20.3%). Mean LVWT was 20.0 ± 4.6mm when measured by CMR and 18.8 ± 4.6mm by echo; when comparing the measures by echo with CMR, there was a positive correlation between them (p &lt; 0.001; r 0.719). Mean HCM Risk-SCD was 2.80 ± 1.51% when measured by CMR and 2.69 ± 1.53% by echo; there was a positive correlation between these measures too (p &lt; 0.001; r 0.963). Maximum LV thickness evaluated by CMR showed a positive correlation (p = 0.006, r 0.384) with the HCM risk-score assessed by CMR. Only 1 pt changed risk group with CMR measurement of maximum LVWT (from G1 to G2). Conclusion: In this cohort, there was a positive, linear relationship between maximum LVWT and HCM Risk-SCD score measured by CMR and echocardiogram. Only 1 pt changed risk stratification group (5-year risk of SCD &lt;4% to 4 to less than 6%). Although CMR measurements, when interpreted correctly, are more precise compared with echocardiography, in this cohort there was no impact on the patient"s future clinical orientation regarding ICD implantation.
Analysis of a large cohort of African/Afro-Caribbean patients by cardiac magnetic resonance
Authors: Nakou E , Peters B , Bromage D , Kellman P , Sado D , Rosmini S 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Limited data is available in the literature on Cardiac Magnetic Resonance (CMR) features of African/Afro-Caribbeans, in particular exploring differences between hypertensive heart disease (HHD) and hypertrophic cardiomyopathy (HCM).

Purpose
To describe the cardiac morphology and pattern of late gadolinium enhancement (LGE) in patients of African/Afro-Caribbean origin.

Methods
We retrospectively analysed African/Afro-Caribbean patients who underwent clinical CMR at a tertiary centre. Three groups were specifically investigated: HHD, HCM and combination of HHD and HCM or ambiguous (HHD&HCM).

Results
Overall, 166 consecutive patients (58% male, mean age 55 ± 14yo) were analysed. One-hundred fifty-four (93%) had history of arterial hypertension (HTN), including 17 with uncontrolled/malignant HTN. Overall, 28(17%) had normal scans, 70(42%) HHD, 15(9%) apical HCM, 10(6%) classical septal HCM, 19(11%) dilated cardiomyopathy, 6(4%) cardiac amyloidosis, 3(2%) ischemic heart disease, 4(2%) myocarditis, 2 sarcoidosis and 1 valvular disease. In 7(4%) the diagnosis was ambiguous between HHD and HCM and 1 uncertain. Forty-four (27%) had dual pathology, most frequently HHD, bystander myocardial infarction (MI) and embolic MI. LGE was detected in 95(57%), 26 with ischemic pattern, 13 diffuse mid-wall, 29 focal non-ischemic and 28 diffuse/multifocal non-ischemic. CMR features and correlations between subgroups are reported in the Table. Patients with HHD had significantly higher left ventricular (LV) end-diastolic (ED) volume indexed (Vi) and LV end-systolic (ES) Vi, but lower LV ejection fraction (EF) and LV maximum wall thickness (MWT) compared to HCM patients. HHD&HCM had higher LVEF and MWT compared to HHD and higher LVEDVi compared to HCM. LGE was more frequently seen in HCM and HHD&HCM as focal non-ischemic (6vs5vs10,p = 0.049) and diffuse multifocal(5vs6vs9,p = 0.009). A history of uncontrolled/malignant HTN was more frequent in HHD and HHD&HCM (11vs1vs5,p = 0.025) and was associated with diffuse LGE with lateral wall involvement (p &lt; 0.0001) (Figure). Conclusions: CMR findings in African/Afro-Caribbeans may overlap between aetiologies. A specific pattern of diffuse non-ischaemic LGE involving the lateral wall appears though to be more often associated with severe uncontrolled HTN.
Table HHD(n = 70) HCM(n = 19) HHD&HCM or ambiguous (n = 13) p LVEDVi, ml/m2 88 ± 33 62 ± 11 77 ± 6 0.003 LVESVi, ml/m2 36 ± 26 16 ± 10 26 ± 19 0.002 LVEF, % 62 ± 16 79 ± 6 74 ± 12 0.567 LVMWT, mm 13 ± 2 15 ± 4 14 ± 3 &lt;0.0001 CMR features and correlations between subgroups Abstract Figure