bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Salem simulator version 2.0: a tool for predicting the productivity of pure and mixed stands and simulating management operations
Authors: Aussenac Raphaël , Pérot Thomas , Fortin Mathieu , de Coligny Francois , Monnet Jean-Matthieu , Vallet Patrick 
Published: June 2021

A growing body of research suggests mixed-species stands are generally more productive than pure stands. However, this effect of mixture depends on species assemblages and environmental conditions and forest managers often lack tools to assess the potential benefit of shifting from pure to mixed stands. Here we present Salem, a simulator filling this gap. Salem predicts the dynamics of pure and mixed even-aged stands and makes it possible to simulate management operations. Its purpose is to be a decision support tool for forest managers and stakeholders as well as for policy makers. It is also designed to conduct virtual experiments and help answer research questions. In Salem, we parameterised the growth in pure stand of 12 common tree species of Europe and we assessed the effect of mixture on species growth for 24 species pairs (made up of the 12 species mentioned above). Thus, Salem makes it possible to compare the productivity of 36 different pure and mixed stands depending on environmental conditions and user-defined management strategies. Salem is essentially based on the analysis of National Forest Inventory data. A major outcome of this analysis is that we found species mixture most often increases species growth, in particular at the poorest sites. Independently from the simulator, foresters and researchers can also consider using the species-specific models that constitute Salem: the growth models including or excluding mixture effect, the bark models, the diameter distribution models, the circumference-height relationship models, as well as the volume equations for the 12 parameterised species. Salem runs on Windows, Linux, or Mac. Its user-friendly graphical user interface makes it easy to use for non-modellers. Finally, it is distributed under a LGPL license and is therefore free and open source.
Trends and predictors of HIV positivity and time since last test at voluntary counselling and testing encounters among adults in Kilifi, Kenya, 2006-2017
Authors: Mugo Peter M. , Agutu Clara A. , Wahome Elizabeth , Juma Margaret , Nzioka Joseph , Mohamed Khamisi , Mumba Teresia , Shally Mahmoud , Fauz Ibrahim , Omar Anisa , Rinke de Wit Tobias F. , van der Elst Elise M. , Graham Susan M. , Sanders Eduard J. 
Published: June 2021

Background: Little is known about HIV retesting uptake among key populations (KP) and general populations (GP) in Kenya. We assessed trends and predictors of first-time testing (FTT), late retesting (previous test more than one year ago for GP or three months for KP), and test positivity at three voluntary counselling and testing (VCT) centres in coastal Kenya. Methods: Routine VCT data covering 2006-2017 was collected from three VCT centres in Kilifi County. We analysed HIV testing history and test results from encounters among adults 18-39 years, categorized as GP men, GP women, men who have sex with men (MSM), and female sex workers (FSW). Results: Based on 24,728 test encounters (32% FTT), we observed declines in HIV positivity (proportion of encounters where the result was positive) among GP men, GP women, first-time testers and MSM but not among FSW. The proportion of encounters for FTT and late retesting decreased for both GP and KP but remained much higher in KP than GP. HIV positivity was higher at FTT and late retesting encounters; at FSW and MSM encounters; and at encounters with clients reporting lower educational attainment and sexually transmitted infection (STI) symptoms. HIV positivity was lower in GP men, never married clients and those less than 35 years of age. FTT was associated with town, risk group, age 18-24 years, never-married status, low educational attainment, and STI symptoms. Late retesting was less common among encounters with GP individuals who were never married, had Muslim or no religious affiliation, had lower educational attainment, or reported STI symptoms. Conclusions: HIV positive test results were most common at encounters with first-time testers and late re-testers. While the proportion of encounters at which late retesting was reported decreased steadily over the period reviewed, efforts are needed to increase retesting among the most at-risk populations.
Induction-phase treatment costs for cryptococcal meningitis in high HIV-burden African countries: New opportunities with lower costs
Authors: Larson Bruce , Shroufi Amir , Muthoga Charles , Oladele Rita , Rajasingham Radha , Jordan Alexander , Jarvis Joseph N. , Chiller Tom M. , Govender Nelesh P. 
Published: June 2021

Introduction: Access to and the cost of induction treatment for cryptococcal meningitis (CM) is rapidly changing. The newly-announced price for flucytosine ($0.75 per 500 mg pill) and possibly lower prices for liposomal amphotericin B (AmB-L) create opportunities to reduce CM treatment costs compared to the current standard treatment in low- and middle-income countries. Methods: We developed an Excel-based cost model to estimate health system treatment costs for CM over a two-week induction phase for multiple treatment combinations, newly feasible with improved access to flucytosine and AmB-L. CM treatment costs include medications, laboratory tests and other hospital-based costs (bed-day costs and healthcare worker time). We report results from applying the model using country-specific information for South Africa, Uganda, Nigeria, and Botswana. Results: A 14-day induction-phase of seven days of inpatient AmB-D with flucytosine, followed by seven days of high-dose fluconazole as an outpatient, will cost health systems less than a 14-day hospital stay with AmB-D and fluconazole. If daily AmB-L replaces AmB-D for those with baseline renal dysfunction, with a cost of $50 or less per 50 mg vial, incremental costs would still be less than the AmB-D with fluconazole regimen. Simple oral combinations (e.g., seven days of flucytosine with fluconazole as an inpatient) are practical when AmB-D is not available, and treatment costs would remain less than the current standard treatment. Conclusions: Improved access to, and lower prices for flucytosine and AmB-L create opportunities for improving CM treatment regimens. An induction regimen of flucytosine and AmB-D for seven days is less costly than standard care in the settings studied here. As this regimen has also been shown to be more effective than current standard care, countries should prioritize scaling up flucytosine access. The cost of AmB-L based regimens is highly dependent on the price of AmB-L, which currently remains unclear.
Towards an integration of two aspects of semiosis – A cognitive semiotic perspective
Authors: Konderak Piotr 
Published: June 2021

Meaning-making processes, understood hierarchically, in line with the Semiotic Hierarchy framework, change on various timescales. To account for and predict these changes, one can take a cognitive view on semiosis. I adopt an interdisciplinary approach combining semiotic studies and cognitive studies in an attempt to account for meaning-making activity and to predict the course of semiosis. In this context, I consider meaning-making activity as shaped by both “external” (to a semiotic system) as well as “internal” factors. I also show how both the “external” and “internal” sources of the dynamicity of meaning-making should be framed in terms of studies on cognition.
I start with a non-standard, 4e approach to meaning-making. According to this framework, meaning-making processes are constituted by (and not just dependent on) environmental and bodily factors. The dynamicity of semiosis can be accounted for in terms of an experiencing, embodied subject (agent) enacting her/his/its own domain of meaningful phenomena. As I argue, this perspective on meaning-making is the cognitive foundation of the first two levels of the Semiotic Hierarchy.
In the following sections I present the Peircean view on signs and semiosis, according to which semiosis is a result of the very nature of a sign and a sign system. In this view, the dynamicity of semiosis has primarily “internal” sources: it stems from the unavoidable fallibility of interpretation and synechism of signs. As I show, this aspect of semiosis can be addressed by means of standard (cognitivist) cognitive science and by means of cognitive modelling.
Ultimately, I sketch a proposal of an attempt to develop a uniform cognitive framework allowing for integration of the above-mentioned aspects of semiosis – a framework based on Rowlands’ idea of the Amalgamated Mind.
Millimeter-level recognition capability of BOTDA based on a transient pump pulse and algorithm enhancement
Authors: Zhou Dengwang , Ba Dexin , Wang Benzhang , Qiu Liqiang , Hasi Wuliji , Dong Yongkang 
Published: June 2021

Brillouin optical time-domain analysis requires a pulsed pump to obtain a distributed Brillouin gain spectrum (BGS) containing environmental information, whose width corresponds to spatial resolution (SR). We propose a rising edge demodulation (RED) algorithm acting on Brillouin information generated by a transient pump pulse (

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lifetime) via a nonlinear weight matrix to enhance SR. The distributed BGS generated by using an 8-ns transient pump pulse is processed by the RED algorithm, and its SR is enhanced from 0.8 m to 1 mm (i.e., 800-fold improvement) in the simulation and 8 mm (i.e., 100-fold improvement) in the experiment.
Prevalence of pulmonary tuberculosis among the tribal populations in India
Authors: Thomas Beena E. , Thiruvengadam Kannan , Vedhachalam Chandrasekaran , A Srividya , Rao V. G. , Vijayachari Paluru , Rajiv Yadav , V Raghavi , Bansal Avi Kumar , Indira Krishna Anil Kumar , Joseph Alex , J Anil Purty , Hussain Tahziba , Anand Praveen , Das Pradeep , John K. R. , Devi K. Rekha , P Sunish , S Azhagendran , Dusthakeer Azger , J Bhat , K. Chadha Vineet , G. S. Toteja , Raghunath Dasarathy , Das Madhuchhanda , Khan A. M. , Kaur Hapreet 
Published: June 2021

ImportanceThere is no concrete evidence on the burden of TB among the tribal populations across India except for few studies mainly conducted in Central India with a pooled estimation of 703/100,000 with a high degree of heterogeneity.ObjectiveTo estimate the prevalence of TB among the tribal populations in India.Design, participants, settingA survey using a multistage cluster sampling design was conducted between April 2015 and March 2020 covering 88 villages (clusters) from districts with over 70% tribal majority populations in 17 States across 6 zones of India. The sample populations included individuals ≥15 years old.Main outcome and measuresEligible participants who were screened through an interview for symptoms suggestive of pulmonary TB (PTB); Two sputum specimens were examined by smear and culture. Prevalence was estimated after multiple imputations for non-coverage and a correction factor of 1.31 was then applied to account for non-inclusion of X-ray screening.ResultsA total of 74532 (81.0%) of the 92038 eligible individuals were screened; 2675 (3.6%) were found to have TB symptoms or h/o ATT. The overall prevalence of PTB was 432 per 100,000 populations. The PTB prevalence per 100,000 populations was highest 625 [95% CI: 496–754] in the central zone and least 153 [95% CI: 24–281] in the west zone. Among the 17 states that were covered in this study, Odisha recorded the highest prevalence of 803 [95% CI: 504–1101] and Jammu and Kashmir the lowest 127 [95% CI: 0–310] per 100,000 populations. Findings from multiple logistic regression analysis reflected that those aged 35 years and above, with BMI <18.5 Kgs /m2, h/o ATT, smoking, and/or consuming alcohol had a higher risk of bacteriologically positive PTB. Weight loss was relatively more important symptom associated with tuberculosis among this tribal populations followed by night sweats, blood in sputum, and fever.Conclusion and relevanceThe overall prevalence of PTB among tribal groups is higher than the general populations with a wide variation of prevalence of PTB among the tribal groups at zone and state levels. These findings call for strengthening of the TB control efforts in tribal areas to reduce TB prevalence through tribal community/site-specific intervention programs.
Is either anosmia or constipation associated with cognitive dysfunction in Parkinson’s disease?
Authors: Sheng Ming-Zhi , Fang Ting-Chun , Chen Yi-Huei , Chang Ming-Hong , Yang Chun-Pai , Lin Ching-Heng 
Published: June 2021

Objective
To clarify the association of anosmia or constipation with cognitive dysfunction and disease severity in patients with Parkinson’s disease (PD).

Methods
Newly diagnosed patients with PD (less than 5 years) without a clinical diagnosis of dementia were included from February 2017 to August 2018. The subjects were further divided into subgroups based on whether anosmia occurred and the grade of constipation. The severity of PD motor symptoms was rated using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), and cognitive functions were evaluated by Montreal Cognitive Assessment (MoCA). Statistical analyses including t-tests, chi-square tests, multiple linear regression, and binary logistic regression were used to determine statistical significance.

Results
A total of 107 newly diagnosed PD patients were included in this study. The MoCA score was significantly lower in the anosmia group (p < 0.001). Constipation was associated with impaired olfaction in a post-hoc test. The correlation coefficient between MoCA and UPSIT score was 0.41 (p < 0.001). Total anosmia and age were associated with cognitive dysfunction (MoCA < 26) (odds ratio, 2.63, p = 0.003; 1.10, p < 0.001, respectively). The anosmia group had a higher MDS-UPDRS part 3 score with β coefficient of 7.30 (p = 0.02). Furthermore, grade 3 constipation was associated with a higher MDS-UPDRS total score with β coefficient of 14.88 (p = 0.02).

Conclusions
Anosmia but not constipation was associated with cognitive impairment in PD patients. Nevertheless, severe constipation was associated with impaired olfaction and PD disease severity. We suggest that the propagation of α-synuclein from the olfactory route is distinct from the enteric nervous system, but the intercommunication between these two routes is complex.
Evaluation of nutritional supplements prescribed, its associated cost and patients knowledge, attitude and practice towards nutraceuticals: A hospital based cross-sectional study in Kavrepalanchok, Nepal
Authors: Shrestha Rabi , Shrestha Sweta , K. C. Badri , Shrestha Sunil 
Published: June 2021

BackgroundThere is substantial increment in nutraceutical consumption in Nepal, although the data on its efficacy and safety is scarce. The practices of nutraceutical supplements users in Nepal remain undocumented. Therefore, this study was conducted to study the prescription pattern, cost, knowledge, attitude and practice (KAP) of the patient towards nutraceutical.MethodsDescriptive cross-sectional study with stratified purposive sampling (n = 400) (patients from the out-patient departments of Scheer Memorial Adventist Hospital, Kavre, Nepal) was performed using a validated structured questionnaire assessing the socio-demographic characteristics, knowledge, attitude, practice of nutraceutical and total cost patients spent on nutraceutical alone. Pearson Chi-square test (x2) was used to investigate the association between socio-demographic variables and patients’ KAP (knowledge, attitude and practice) towards nutraceutical. One way ANOVA was performed to compare the cost of nutraceutical among the different outpatient departments.ResultsMore than 80% of patients were found to be consuming nutraceutical on their own. The mostly prescribed nutraceutical were vitamins (40.7%), minerals (23.7%), enzymes (21.1%), proteins (8.8%), probiotics (4.2%) and herbals (2.0%). With the most common reasons for consuming nutraceutical were to maintain good health (70.0%) and healthcare professionals (57.85%) were the most approached source of information for nutraceutical. Nearly half of the patients (46.5%) had an inadequate level of knowledge whereas more than two-third (71.5%) showed a moderate positive attitude towards nutraceutical use. The average amount patients spent was NRs.575.78 [equivalent to USD 4.85] per prescription on nutraceutical alone. The maximum cost amounted to NRs 757.18 [equivalent to USD 6.43] in Orthopedics, and the minimum cost was NRs 399.03 [equivalent to USD 3.36] in Obstetrics and gynecology, respectively. There was a significant difference (p<0.001) in cost of nutraceutical prescribed between the OPD clinics.ConclusionThe higher prevalence of inadequate knowledge despite moderate positive attitude towards nutraceutical among patients regarding some significant issues such as safety and interactions of nutraceutical consumption and its’ substitution for meals reflects the need to develop an educational strategy to increase general public awareness on the rational use of nutraceutical.
Developing a protocol for adapting multimedia patient-reported outcomes measures for low literacy patients
Authors: Long Chao , Beres Laura K. , Wu Albert W. , Giladi Aviram M. 
Published: June 2021

Background
Self-administration of patient-reported outcomes measures (PROMs) by patients with low literacy is a methodologic and implementation challenge. There is an increasing emphasis on patient-centered care and wider adoption of PROMs to understand outcomes and measure healthcare quality. However, there is a risk that the use of PROMs could perpetuate health disparities unless they are implemented in an inclusive fashion. We present a protocol to adapt validated, text-based PROMs to a multimedia format (mPROMs) to optimize self-administration in populations with limited literacy. We describe the processes used to develop the protocol and the planned protocol implementation.

Methods/Design
Our study protocol development was guided by the International Quality of Life Assessment (IQOLA) protocol for translating and culturally adapting PROMs to different languages. We used the main components of IQOLA’s protocol to generate a conceptual framework to guide development of a Multimedia Adaptation Protocol (MAP). The MAP, which incorporates human-centered design (HCD) and takes a community-engaged research approach, includes four stages: forward adaptation, backward adaptation, qualitative evaluation, and validation. The MAP employs qualitative and quantitative methods including observation, cognitive and discovery interviews, ideation workshops, prototyping, user testing, co-creation interviews, and psychometric testing. An iterative design is central to the MAP and consistent with both the IQOLA protocol and HCD processes. We will pilot test and execute the MAP to adapt the Patient Reported Outcomes Measurement Information System (PROMIS) Upper Extremity Short Form for use in a mixed literacy hand and upper extremity patient population in Baltimore, Maryland.

Discussion
The MAP provides an approach for adapting PROMs to a multimedia format. We encourage others to evaluate and test this approach with other questionnaires and patient populations. The development and use of mPROMs has the potential to expand our ability to accurately capture PROs in limited literacy populations and promote equity in PRO measurement.
Comparison between femoral block and PENG block in femoral neck fractures: A cohort study
Authors: Allard Céline , Pardo Emmanuel , de la Jonquière Christophe , Wyniecki Anne , Soulier Anne , Faddoul Annibal , Tsai Eileen S. , Bonnet Francis , Verdonk Franck 
Published: June 2021

BackgroundRegional analgesia is worth performing in the multimodal postoperative management of hip fracture (HF) because it reduces hospital morbidity and mortality. The aim of this study is to compare the efficacy and side effects of the recently described “Pericapsular Nerve Group (PENG) Block” with those of the femoral block, which is considered the standard of care for postoperative pain control after femoral neck fracture.Materials and methodsWe conducted a comparative observational study at a university hospital (Saint Antoine Hospital, Sorbonne University, Paris, France), where the PENG block was introduced in August 2019. We include all patients from June to October 2019, who were coming for femoral neck fractures and who had an analgesic femoral block or PENG block before their surgery. The primary outcome was the comparison of cumulative postoperative morphine consumption 48 hours after surgery.ResultsDemographics, medical charts, and perioperative data of 42 patients were reviewed: 21 patients before (Femoral group) and 21 patients after the introduction of PENG block (PENG group) in clinical practice. Thirteen total hip arthroplasties (THA) and eight hemi arthroplasties (HA) were included in each group. Demographics were also comparable. The median, postoperative, morphine equivalent consumption at 48 hours was 10 [0–20] mg and 20 [0–50] mg in Femoral and PENG groups respectively (p = 0.458). No statistically significant differences were found in postoperative pain intensity, time to ambulation, incidence of morphine-related side effects, or length of hospital stay. The postoperative muscle strength of the quadriceps was greater in the PENG group than in the Femoral group (5/5 vs. 2/5, p = 0.001).ConclusionIn the management of hip fractures, PENG block is not associated in our study with a significant change in postoperative morphine consumption, compared to femoral block. However, it does significantly improve the immediate mobility of the operated limb, making it appropriate for inclusion in enhanced recovery programs after surgery.