bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Contagion in a Two‐Country Model
Authors: MATSUOKA TARISHI 
Published: December 2021

AbstractThis paper studies a two‐country version of the standard banking model with financial markets to investigate the effects of financial market globalization on financial stability. In autarky, two types of banks arise endogenously: some always remain solvent and others can default. When the financial markets are integrated, three types of banks can arise endogenously, and some banks go bankrupt because of the liquidity shock of another country. I show that financial market globalization can cause financial contagion and reduce welfare. In addition, the endogenous heterogeneous risk profile of the two countries can be observed.
College Students Who Are Mindful About Math Achieve Better Grades
Authors: Weed Keri , Usry Christian Hope , Stafford Jane 
Published: December 2021

AbstractHigh levels of math anxiety combined with low levels of mindfulness may contribute to disproportionate failure rates in introductory college mathematics classes. Although research has confirmed benefits of mindfulness in reducing anxiety and stress, findings have been less clear regarding links between mindfulness and achievement outcomes. The current study used an adapted version of the Five Factor Mindfulness Questionnaire, with items reworded specifically for activities related to math, to investigate roles of both math anxiety and mindfulness on midterm course grades. Undergraduate math students completed a brief test of math skills, and questionnaires about math anxiety, general mindfulness, and mindfulness about math during the first week of the semester. Course grades were collected at midterm. Results revealed that math skills and the act with awareness facet of mindfulness were significantly associated with course grades. Supporting mindful awareness during introductory college math classes may also enhance achievement outcomes.
Burkholderia cepacia—A rare but important cause of refractory peritonitis in patients with continuous ambulatory peritoneal dialysis: A case report and literature review
Authors: Huang Xiu , Yang Ting , Li Min , Wang Chendan , Zhou Yun , Zhang Jie 
Published: December 2021

AbstractRefractory peritonitis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) caused by Burkholderia cepacia is very rare. Herein, we describe a case of B. cepacia‐related refractory peritonitis and present a literature review of similar cases. A 62‐year‐old male patient presented with diffuse abdominal pain, bloating, and turbid peritoneal effluent. Initial dialysis effluent culture was negative for any microorganism. The patient initially underwent treatment with piperacillin–sulbactam. The second dialysis effluent culture was positive for gram stain and later tested positive for B. cepacia. Peritoneal dialysis (PD) catheter removal was recommended, and the patient agreed to undergo regular hemodialysis. To the best of our knowledge, this is the first case of B. cepacia‐related refractory peritonitis in a patient undergoing CAPD with no history of a recent hospitalization. B. cepacia infections can result in death in some areas. Therefore, timely catheter removal and switching treatment to hemodialysis is recommended for patients with B. cepacia‐related refractory peritonitis.
Risk of left atrial appendage thrombus and stroke in patients with atrial fibrillation and mitral regurgitation
Authors: Melduni Rowlens , Nkomo Vuyisile T , Wysokinski Waldemar , Gersh Bernard J , Deshmukh Abhishek , Padang Ratnasari , Greene Eddie L , Oh Jae K , Lee Hon-Chi 
Published: December 2021

ObjectiveTo investigate the association of mitral regurgitation (MR) on thromboembolic risk of patients with non-valvular atrial fibrillation (NVAF) undergoing transoesophageal echocardiography (TEE)-guided cardioversion.MethodsData for consecutive patients who underwent TEE-guided cardioversion for NVAF between 2000 and 2012 were analysed. MR severity was assessed by Doppler echocardiography and classified as ≤mild, moderate or severe. Left atrial appendage emptying velocities were averaged for five consecutive cycles. Multivariable regression models were used to identify independent predictors of left atrial appendage thrombus (LAAT) and stroke.Results2950 patients (age, 69.3±12.2 years, 67% men) were analysed. 2173 (73.7%) had ≤mild MR; 631 (21.4%), moderate MR; and 146 (4.9%), severe MR. Patients with moderate (age, 72.4±10.7 years) and severe (age, 72.8±12.1 years) MR were older than those with ≤mild MR (age, 68.2±12.5 years). The prevalence of LAAT was 1.5% (n=43). CHA2DS2-VASc scores (≤mild MR, 3.0±1.6; moderate MR, 3.5±1.5; severe MR, 3.9±1.5; p<0.001) and heart failure frequency (≤mild MR, 38.4%; moderate MR, 48.0%; severe MR, 69.2%; p<0.001) were increasingly higher with greater MR severity. Multivariable logistic regression analysis showed no association of moderate MR (OR 0.77, 95% CI 0.38 to 1.56) or severe MR (OR 0.55, 95% CI 0.21 to 1.49) with LAAT. During a mean follow-up of 7.3±5.1 years (median 7.5, IQR, 2.7–10.9), 216 patients had an ischaemic stroke. Adjusted Cox regression analysis showed no significant association of moderate MR (HR 1.22, 95% CI 0.88 to 1.68) or severe MR (HR 0.73, 95% CI 0.31 to 1.46) with stroke.ConclusionsAmong patients with NVAF, the presence or severity of MR was not associated with a decreased risk of LAAT or stroke.
Safety and efficacy of the tumor-selective adenovirus enadenotucirev with or without paclitaxel in platinum-resistant ovarian cancer: a phase 1 clinical trial
Authors: Moreno Victor , Barretina-Ginesta Maria-Pilar , García-Donas Jesús , Jayson Gordon C , Roxburgh Patricia , Vázquez Raúl Márquez , Michael Agnieszka , Antón-Torres Antonio , Brown Richard , Krige David , Champion Brian , McNeish Iain 
Published: December 2021

BackgroundTreatment outcomes remain poor in recurrent platinum-resistant ovarian cancer. Enadenotucirev, a tumor-selective and blood stable adenoviral vector, has demonstrated a manageable safety profile in phase 1 studies in epithelial solid tumors.MethodsWe conducted a multicenter, open-label, phase 1 dose-escalation and dose-expansion study (OCTAVE) to assess enadenotucirev plus paclitaxel in patients with platinum-resistant epithelial ovarian cancer. During phase 1a, the maximum tolerated dose of intraperitoneally administered enadenotucirev monotherapy (three doses; days 1, 8 and 15) was assessed using a 3+3 dose-escalation model. Phase 1b included a dose-escalation and an intravenous dosing dose-expansion phase assessing enadenotucirev plus paclitaxel. For phase 1a/b, the primary objective was to determine the maximum tolerated dose of enadenotucirev (with paclitaxel in phase 1b). In the dose-expansion phase, the primary endpoint was progression-free survival (PFS). Additional endpoints included response rate and T-cell infiltration.ResultsOverall, 38 heavily pretreated patients were enrolled and treated. No dose-limiting toxicities were observed at any doses. However, frequent catheter complications led to the discontinuation of intraperitoneal dosing during phase 1b. Intravenous enadenotucirev (1×1012 viral particles; days 1, 3 and 5 every 28-days for two cycles) plus paclitaxel (80 mg/m2; days 9, 16 and 23 of each cycle) was thus selected for dose-expansion. Overall, 24/38 (63%) patients experienced at least 1 Grade ≥3 treatment-emergent adverse event (TEAE); most frequently neutropenia (21%). Six patients discontinued treatment due to TEAEs, including one patient due to a grade 2 treatment-emergent serious AE of catheter site infection (intraperitoneal enadenotucirev monotherapy). Among the 20 patients who received intravenous enadenotucirev plus paclitaxel, 4-month PFS rate was 64% (median 6.2 months), objective response rate was 10%, 35% of patients achieved stable disease and 65% of patients had a reduction in target lesion burden at ≥1 time point. Five out of six patients with matched pre-treatment and post-treatment biopsies treated with intravenous enadenotucirev plus paclitaxel had increased (mean 3.1-fold) infiltration of CD8 +T cells in post-treatment biopsies.ConclusionsIntravenously dosed enadenotucirev plus paclitaxel demonstrated manageable tolerability, an encouraging median PFS and increased tumor immune-cell infiltration in platinum-resistant ovarian cancer.Trial registration numberNCT02028117.
Test–retest reliability of outcome measures: data from three trials in radiographic and non-radiographic axial spondyloarthritis
Authors: Boel Anne , Navarro-Compán Victoria , van der Heijde Désirée 
Published: December 2021

ObjectivesAim of this study was to assess test–retest reliability of candidate instruments for the mandatory domains of the Assessment of Spondyloarthritis international Society (ASAS)-Outcome Measures in Rheumatology core set for axial spondyloarthritis (axSpA).MethodsScreening and baseline data from COAST-V, COAST-X and RAPID-axSpA was used to evaluate test–retest reliability of each candidate instrument for the mandatory domains (disease activity, pain, morning stiffness, fatigue, physical function, overall functioning and health). A maximum time interval of 28 days between both visits was used for inclusion in this study. Test–retest reliability was assessed by intraclass correlation coefficient (ICC). Bland and Altman plots provided mean difference and 95% limits of agreement, which were used to calculate the smallest detectable change (SDC). Data were analysed for radiographic and non-radiographic axSpA separately.ResultsGood reliability was found for Ankylosing Spondylitis Disease Activity Score (ICC 0.79, SDC 0.6), C reactive protein (ICC 0.72–0.79, SDC 12.3–17.0), Bath Ankylosing Spondylitis Functional Index (ICC 0.87, SDC 1.1) and 36-item Short-Form Health Survey (ICC Physical Component Summary 0.81, SDC 4.7, Mental Component Summary 0.80, SDC 7.3). Moderate reliability was found for Bath Ankylosing Spondylitis Disease Activity Index (ICC 0.72, SDC 1.1), patient global assessment (ICC 0.58, SDC 1.5), total back pain (ICC 0.64, SDC 1.3), back pain at night (ICC 0.67, SDC 1.3), morning stiffness (ICC 0.52–0.63, SDC 1.5–2.2), fatigue (ICC 0.65, SDC 1.3) and ASAS-Health Index (ICC 0.74, SDC 2.5). Reliability and SDC for the radiographic and non-radiographic axSpA subgroups were similar.ConclusionOverall reliability was good, and comparable levels of reliability were found for patients with radiographic and non-radiographic axSpA, even though most instruments were developed for radiographic axSpA. Composite measures showed higher reliability than single-item measures in assessing disease activity in patients with axSpA.
Assessment of sediment arsenic and iron occurrence and leaching potential in a potable water treatment plant wastewater stabilization pond system
Authors: Ekhlasi Nia Ali , Bull Harrison , Asadi Mohsen , McPhedran Kerry 
Published: December 2021

Wastewater stabilization ponds (WSPs) are commonly used to reduce wastewater metal(loid) concentrations from drinking water treatment plants (DWTPs) through sedimentation. However, this results in increased sediment concentrations that can be released back into the overlying water. Thus, our goal was to evaluate the WSP metal(loid)s occurrence and leaching potential. Currently, a Saskatchewan based DWTP’s WSP system was investigated given historically elevated effluent As and Fe concentrations. The WSP consists of five ponds that were sampled on six occasions in 2019 and 2020. In addition, sediments were used in laboratory-based experiments to determine their leaching potential. Overall, the sediments were found to contain elevated concentrations of As and Fe of 25 to 400 mg/kg and 10 000 to 45 000 mg/kg, respectively. Leaching experiments indicated that the pond sediments could potentially release As and Fe with log Kd values ranging from 2.21 to 4.31 L/kg, whereas Fe ranged from 3.32 to 5.53 L/kg.
Effects of Continuous vs Discrete Frequency Scaling and Core Allocation on Energy Efficiency of Static Schedules for Moldable Tasks
Authors: Litzinger Sebastian , Keller Jörg 
Published: December 2021

Models for energy-efficient static scheduling of parallelizable tasks with deadlines on frequency-scalable parallel machines comprise moldable vs. malleable tasks and continuous vs. discrete frequency levels, plus preemptive vs. non-preemptive task execution with or without task migration. We investigate the tradeoff between scheduling time and energy efficiency when going from continuous to discrete core allocation and frequency levels on a multicore processor, and from preemptive to non-preemptive task execution. To this end, we present a tool to convert a schedule computed for malleable tasks on machines with continuous frequency scaling [Sanders and Speck, Euro-Par (2012)] into one for moldable tasks on a machine with discrete frequency levels. We compare the energy efficiency of the converted schedule to the energy consumed by a schedule produced by the integrated crown scheduler [Melot et al., ACM TACO (2015)] for moldable tasks and a machine with discrete frequency levels. Our experiments with synthetic and application-based task sets indicate that the converted Sanders Speck schedules, while computed faster, consume more energy on average than crown schedules. Surprisingly, it is not the step from malleable to moldable tasks that is responsible but the step from continuous to discrete frequency levels. One-time frequency scaling during a task’s execution can compensate for most of the energy overhead caused by frequency discretization.
Tumor-Specificity Growth Factor Combined with Tumor Markers in Nuclear Medicine Imaging to Identify Prostate Cancer Osteonosus
Authors: Zhang Xuemin , Chen Zhengfu 
Published: December 2021

Objective. This study has explored the application value of malignant tumor SPE growth factor (TSGF) combined with tumor markers (TM) (TSGF + TM) in nuclear medicine imaging to identify prostate cancer osteonosus (PCO). Methods. A retrospective analysis for 70 patients with prostate cancer and bone disease admitted to our hospital was performed, 30 healthy persons in the same period were selected as the control group, and the advantages and disadvantages of various examinations were analyzed. All patients were diagnosed with PET whole body bone imaging. Suspicious lesions could be examined by MRI or CT. According to the results of imaging examination, patients were divided into 40 cases of malignant prostate cancer and 30 cases of benign prostate cancer. All the patients underwent 18F-FDG-PET imaging, alpha-fetoprotein (AFP), and TSGF + TM determination. The case diagnosis results were compared and analyzed, and the sensitivity (SEN), specificity (SPE), and accuracy (ACC) of various detection methods were calculated. The SEN, SPE, and ACC of positron emission tomography (PET) were 90.9%, 57.8%, and 81.2%, respectively; those of TM were 79.2%, 94.6%, and 69.8%, respectively; and those of TSGF + TM were 95.9%, 100%, and 97.3%, respectively. The accuracy of combined diagnosis of tumors can reach 100%. The AFP and TSGF levels of serum TM were compared and analyzed, and it was found that the benign lesion group and the malignant lesion group showed significant increases compared with the control group, and the difference between the malignant lesion group and the control group was obvious (

P

< 0.05). SGF combined with TM could obtain a more definite diagnosis in PCO. Conclusion. TSGF + TM combined with 18F-FDG-PET imaging showed important clinical value to diagnose the PCO. The imaging accuracy of TSGF + TM combined with 18F-FDG-PET is 97.3%, and the specificity of tumor diagnosis is 100%. Therefore, the TSGF + TM applied in medical imaging and identification of PCO was worthy of clinical promotion.
Mechanical Thrombectomy Up to 24 Hours in Large Vessel Occlusions and Infarct Velocity Assessment
Authors: Inoue Manabu , Yoshimoto Takeshi , Tanaka Kanta , Koge Junpei , Shiozawa Masayuki , Nishii Tatsuya , Ohta Yasutoshi , Fukuda Tetsuya , Satow Tetsu , Kataoka Hiroharu , Yamagami Hiroshi , Ihara Masafumi , Koga Masatoshi , Mlynash Michael , Albers Gregory W. , Toyoda Kazunori 
Published: December 2021

Background
We retrospectively compared early‐ (<6 hours) versus late‐ (6–24 hours) presenting patients using perfusion‐weighted imaging selection and evaluated clinical/radiographic outcomes.

Methods and Results

Large vessel occlusion patients treated with mechanical thrombectomy from August 2017 to July 2020 within 24 hours of onset were retrieved from a single‐center database. Perfusion‐weighted imaging was analyzed by automated software and final infarct volume was measured semi‐automatically within 14 days. The primary end point was good outcome (modified Rankin Scale 0–2 at 90 days). Secondary end points were excellent outcome (modified Rankin Scale 0–1 at 90 days), symptomatic intracranial hemorrhage, and death. Clinical characteristics/radiological values including hypoperfusion volume and infarct growth velocity (baseline volume/onset‐to‐image time) were compared between the groups. Of 1294 patients, 118 patients were included. The median age was 74 years, baseline National Institutes of Health Stroke Scale score was 14, and core volume was 13 mL. The late‐presenting group had more female patients (67% versus 31%, respectively;
P
=0.001). No statistically significant differences were seen in good outcome (42% versus 53%, respectively;
P
=0.30), excellent outcome (26% versus 32%, respectively;
P
=0.51), symptomatic intracranial hemorrhage (6.5% versus 4.6%, respectively;
P
=0.74), and death (3.2% versus 5.7%, respectively;
P
=0.58) between the groups. The late‐presenting group had more atherothrombotic cerebral infarction (19% versus 6%, respectively;
P
=0.03), smaller hypoperfusion volume (median: 77 versus 133 mL, respectively;
P
=0.04), and slower infarct growth velocity (median: 0.6 versus 5.1 mL/h, respectively;
P
=0.03).

Conclusions
Patients with early‐ and late‐time windows treated with mechanical thrombectomy by automated perfusion‐weighted imaging selection have similar outcomes, comparable with those in randomized trials, but different in infarct growth velocities.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02251665.
The Dimensions of Attila the Hun
Authors: McDonald William C. 
Published: December 2021

Abstract
For well over a millennium after his death in the fifth century, Attila the Hun was victim to calumnious artistic and verbal representations as the quintessential barbarian and Other. Some historians defamed him a half-human. Others slandered his name by adapting a brief corporeal catalog compiled by Jordanes in the Getica (c. 551), a history of the Goths. Jordanes’ pejorative assessment of Attila’s supposed physical characteristics (arrogant gait and gaze, snub nose, alleged offensive skin pigmentation) served later chroniclers as an explanation for the failures and successes of Attila, helping to influence reader perception. Medieval and early modern representations of Attila call to mind the campaign against Tamerlane in art and print. Here are gathered for the first time several early German versions of the physical features of Attila, as transmitted by Jordanes.
Gaulish Warriors and Finnish Shoes
Authors: Markey Thomas L. 
Published: December 2021

Abstract
OIr. cing ‘hero’ and cingid ‘steps (marches)’ are reflected in the aristocratic Gaulish name Cingetorix ‘king of marchers (warriors), heroes’. These Celtic tokens, altogether lacking in Italic, have sometimes been considered reflexes of IE *(s)keng- which appears in Classical Sanskrit as khā̆ñjati ‘limps’ and in Greek as σκάζω ‘limp’. It has also been argued that late prehistoric Germanic borrowed a Celtic *kanxsto- ‘stepper, trotter’ (or the like) which it deployed in equestrian terms; so, for example, Old English hengest, hengst ‘gelding, horse’. The pejorative ‘limping’ sense of IE *(s)keng-, which is still maintained in German hinken, was mistakenly thought to have been ameliorated in Celtic allowing cingid to express ‘to step, proceed go, stride, march’. Here, however, it is shown that, other than in loans from Germanic, Celtic lacked reflexes of IE *(s)keng-. It is then demonstrated that Celtic *keng-, as in OIr. cingid, was derived by dissimilation of IE *g̑hengh- ‘to go, stride, ride’. Finally, it is remarked that Proto-Finnic borrowed Proto-Germanic *skenka- < IE *(s)keng- and adapted it as *kenkä > Finnish kenkä / kengä ‘shoe/boot (anything resembling a shoe in function, a heavy boot … for walking or striding in snow)’.
Prospective and Retrospective: Le Corbusier’s Twofold Voyage d’Orient
Authors: Huet Jacobé 
Published: December 2021

Abstract
In 1911, a twenty-three-year-old Le Corbusier embarked on a six-month journey from Dresden to Istanbul, and back to his native Switzerland through Greece and Italy. Upon his return, the young architect unsuccessfully attempted to publish his travel notes as a book in 1912 and again in 1914. Only in 1965, forty days before his death, did Le Corbusier conduct the final revision of his 1914 typescript for publication. The next year, Le Voyage d’Orient was published posthumously. Previous scholarship on this book has overlooked the importance of Le Corbusier’s 1965 edits, consequently approaching the work as an authentic testament of the author’s youthful spirit. Based on a new and contextualized reading of the 1914 typescript hand-annotated by Le Corbusier in 1965, this article demonstrates how the late edits constitute a re-writing of a segment of Le Corbusier’s own history, especially in relation to his ideas of modernity, tradition, inspiration, and attachment to Mediterranean architecture.
The Sekbanbaşı Mescidi or a Lesser-Known Middle Byzantine Church Typology at Constantinople
Authors: Taddei Alessandro 
Published: December 2021

Abstract
Cross-in-square churches are an exceptional feature for the middle Byzantine architecture of Constantinople. The simpler variant of this architectural type is widely known from ‘provincial’ contexts but appears seldomly throughout the city. It should not be absent from modern scholarship, since some few examples of this type of church had survived well into the early 20th century. Because of this paucity of scholarship, the history, functions, and phases of these small edifices are mostly unknown. The now lost Sekbanbaşı Mescidi is a case in point.
Monastic Pathways on the Fourth and Fifth Hills of Constantinople (Eleventh–Fifteenth Centuries)
Authors: Melvani Nicholas 
Published: December 2021

Abstract
The area between the so-called Fourth and Fifth hills of Constantinople is known for its monasteries, especially those from the Komnenian and Palaiologan periods. In general, this part of the city was less urbanised and was therefore suitable for monastic life, but it was intimately connected with various aspects of social, economic, and scholarly activity. The present article examines monuments and itineraries in this area within the urban context and the ceremonial topography of medieval Constantinople in order to highlight the place of these monastic neighborhoods in the Byzantine capital’s public life.