bluuebunny/crossref_metadata_2025_split huggingface dataset:
The skill of self-control
Authors: Bermúdez Juan Pablo 
Published: February 2021

AbstractResearchers often claim that self-control is a skill. It is also often stated that self-control exertions are intentional actions. However, no account has yet been proposed of the skillful agency that makes self-control exertion possible, so our understanding of self-control remains incomplete. Here I propose theskill model of self-control, which accounts for skillful agency by tackling the guidance problem: how can agents transform their abstract and coarse-grained intentions into the highly context-sensitive, fine-grained control processes required to select, revise and correct strategies during self-control exertion? The skill model borrows conceptual tools from ‘hierarchical models’ recently developed in the context of motor skills, and asserts that self-control crucially involves the ability to manage the implementation and monitoring of regulatory strategies as the self-control exercise unfolds. Skilled agents are able do this by means offlexible practical reasoning: a fast, context-sensitive type of deliberation that incorporates non-propositional representations (including feedback signals about strategy implementation, such as the feeling of mental effort) into the formation and revision of the mixed-format intentions that structure self-control exertion. The literatures on implementation intentions and motivation framing offer corroborating evidence for the theory. As a surprising result, the skill of self-control that allows agents to overcome the contrary motivations they experience is self-effacing: instead of continuously honing this skill, expert agents replace it with a different one, which minimizes or prevents contrary motivations from arising in the first place. Thus, the more expert you are at self-control, the less likely you are to use it.
Comparison of two Turnip mosaic virus P1 proteins in their ability to co-localize with the Arabidopsis thaliana G3BP-2 protein
Authors: Reuper Hendrik , Krenz Björn 
Published: February 2021

AbstractTurnip mosaic virus (TuMV), belonging to the genus Potyvirus (family Potyviridae), has a large host range and consists of a single-stranded positive sense RNA genome encoding 12 proteins, including the P1 protease. This protein which is separated from the polyprotein by cis cleavage at its respective C-terminus, has been attributed with different functions during potyviral infection of plants. P1 of Turnip mosaic virus (P1-TuMV) harbors an FGSF-motif and FGSL-motif at its N-terminus. This motif is predicted to be a binding site for the host Ras GTPase-activating protein-binding protein (G3BP), which is a key factor for stress granule (SG) formation in mammalian systems and often targeted by viruses to inhibit SG formation. We therefore hypothesized that P1-TuMV might interact with G3BP to control and regulate plant SGs to optimize cellular conditions for the production of viral proteins. Here, we analyzed the co-localization of the Arabidopsis thaliana G3BP-2 with the P1 of two TuMV isolates, namely UK 1 and DEU 2. Surprisingly, P1-TuMV-DEU 2 co-localized with AtG3BP-2 under abiotic stress conditions, whereas P1-TuMV-UK 1 did not. AtG3BP-2::RFP showed strong SGs formation after stress, while P1-UK 1::eGFP maintained a chloroplastic signal under stress conditions, the signal of P1-DEU 2::eGFP co-localized with that of AtG3BP-2::RFP. This indicates a specific interaction between P1-DEU 2 and the AtG3BP family which is not solely based on the canonical interaction motifs.
Comparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial
Authors: Spanier Britta , Laurençon Anne , Weiser Anna , Pujol Nathalie , Omi Shizue , Barsch Aiko , Korf Ansgar , Meyer Sven W. , Ewbank Jonathan J. , Paladino Francesca , Garvis Steve , Aguilaniu Hugo , Witting Michael 
Published: February 2021

Abstract
Introduction
Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. Despite much progress in lipidomics, there remains, as for all high throughput “omics” strategies, the need to develop strategies to standardize and integrate quality control into studies in order to enhance robustness, reproducibility, and usability of studies within specific fields and beyond.

Objectives
We aimed to understand how much results from lipid profiling in the model organism Caenorhabditis elegans are influenced by different culture conditions in different laboratories.

Methods
In this work we have undertaken an inter-laboratory study, comparing the lipid profiles of N2 wild type C. elegans and daf-2(e1370) mutants lacking a functional insulin receptor. Sample were collected from worms grown in four separate laboratories under standardized growth conditions. We used an UPLC-UHR-ToF–MS system allowing chromatographic separation before MS analysis.

Results
We found common qualitative changes in several marker lipids in samples from the individual laboratories. On the other hand, even in this controlled experimental system, the exact fold-changes for each marker varied between laboratories.

Conclusion
Our results thus reveal a serious limitation to the reproducibility of current lipid profiling experiments and reveal challenges to the integration of such data from different laboratories.
SUITMAs as an archive of the human past: educational implications
Authors: Urbańska Magdalena , Charzyński Przemysław 
Published: February 2021

Abstract
Purpose
The relics of the industry are widely used for educational and touristic purposes. There are many examples of brownfield sites turned into tourist attractions. Interest in post-industrial areas concerns not only an infrastructure and ruins but also the soil cover. Soils in such areas should be also considered as important element of this type of landscape due to the artefacts’ stored. This article aim is to present educational potential of post-industrial soils and artefacts to be found there on the example of the area of “Polchem”.

Methods and materials
This publication is based on the analysis of soils’ artefacts in the non-reclaimed area of former chemical plant. Photographic material and literature studies focus on technogenic soils and its functions. The history of “Polchem”, industrial tourism and industrial archaeology as well as verbal communication of people associated with the company were important components of this publication.

Results and discussion
Soils play many ecological functions, one of them is archiving human history. In this approach, archaeology is combined with soil science serving as a tool in archaeological research. Such cooperation within two scientific fields leads often to valuable scientific achievements. Relatively young post-industrial areas are generally out of interest of archaeology. However, they can form the basis of soil education activities targeted at a larger number of recipients.

Conclusions
Soils within cities are interesting due to recorded marks of human activity. Artefacts in soils can be used in various ways. One of them is an educational purpose. “Polchem” area is out of use now so it can be accessed by visitors (students and teachers). Artefact’s diversity allows for quick finding and recognition of industrial history of the former plant. In this way, it could be present an important soil function—protecting cultural heritage.
Fear of COVID-19 and Depression: A Comparative Study Among the General Population and Healthcare Professionals During COVID-19 Pandemic Crisis in Bangladesh
Authors: Sakib Najmuj , Akter Tahmina , Zohra Fatematuz , Bhuiyan A. K. M. Israfil , Mamun Mohammed A. , Griffiths Mark D. 
Published: February 2021

AbstractThe COVID-19 pandemic affects individuals’ mental health that can result in fear of getting COVID-19 infection and depression. As there is no prior study available, we evaluated these mental health outcomes and associated factors among the general population and healthcare professionals (HCPs) in Bangladesh. This nationwide cross-sectional study comprised 3388 individuals including 834 HCPs. The measures included socio-demographics, healthcare, and patient-care related information, the Bangla Patient Health Questionnaire, and the Bangla Fear of COVID-19 Scale. Multiple linear regression analyses were performed to identify risk factors. Just over one-quarter of the participants were depressed, and was significantly associated with COVID-19 fear. Regression analyses showed that, both in general population and HCPs, depression and fear of COVID-19 were strongly predicted by being female; however, depression was inversely associated with being married. Particularly, among the HCPs, being restless while examining a patient with flu-like symptoms and while examining a patient returning from abroad was found to be significant predictor for both depression and fear of COVID-19. HCPs who were using single protective equipment for a week had greater depression and those who felt insecure due to the pandemic had a high level of COVID-19 fear. The findings identified major psychological impacts among the participants, suggesting the urgent need to promote mental wellbeing in both general population and medical professionals.
Qualitative research: extending the range with flexible pattern matching
Authors: Bouncken Ricarda B. , Qiu Yixin , Sinkovics Noemi , Kürsten Wolfgang 
Published: February 2021

AbstractThe flexible pattern matching approach has witnessed increasing popularity. By combining deduction with induction in logic, flexible pattern matching is well suited for exploration and theory development. The paper discusses its logic, advantages and process of this approach while offering a review of research adopting this approach. We also compare and contrast it with another popular qualitative data analysis technique, the grounded theory approach, to further ground the method on the established knowledge and elaborate its strength and fitting context. This paper advances the flexible pattern matching approach by suggesting a five-step roadmap to conduct qualitative research with the approach.
Designing and enacting instruction that enhances language for mathematics learning: a review of the state of development and research
Authors: Erath Kirstin , Ingram Jenni , Moschkovich Judit , Prediger Susanne 
Published: February 2021

AbstractAfter four decades of research and development on language in mathematics classrooms, there is consensus that enhancing language is crucial for promoting students’ mathematics learning. After briefly sketching the theoretical contexts for work on this topic, in this paper we present six design principles for instruction that enhances language for mathematics learning. We then review the research that provides an empirical foundation for these principles, (a) concerning the design of learning environments to enhance language for mathematics learning and (b) on teaching practices (including teacher moves and classroom norms) involved in the enactment of those designed learning environments. Without claiming completeness, this review of the state of development and research shows that some aspects of design and instruction that enhance language for mathematics learning have been well researched, whereas research gaps for other aspects persist.
EDTA interfacial chelation Ca2+ incorporates superhydrophobic coating for scaling inhibition of CaCO3 in petroleum industry
Authors: Zhu Ming-Liang , Qian Hui-Juan , Yuan Rui-Xia , Zhao Dong-Yan , Huang Hai-Chao , Wang Huai-Yuan 
Published: February 2021

AbstractIn this paper, the superhydrophobic poly(vinylidene fluoride)/fluorinated ethylene propylene/SiO2/CNTs-EDTA (PFSC-EDTA) composite coating was successfully fabricated and applied for anti-scaling performance. The deposition of CaCO3 on the surface of the superhydrophobic PFSC-EDTA composite coating reached 0.0444 mg/cm2 for 192-h immersion into the supersaturated CaCO3 solution, which was only 11.4% that of the superhydrophobic PFSC composite coating. At the interface between the CaCO3 solution and the PFSC-EDTA coating, the Ca2+ could be firstly chelated by EDTA that was benefit for improving the anti-scaling performance of the superhydrophobic PFSC-EDTA composite coating. In another hand, the addition of EDTA to the CNTs played an important role in fabricating the SiO2-centric and CNTs-EDTA-surrounded multilevel micro–nanostructure in the superhydrophobic PFSC-EDTA composite coating, in favor of maintaining the air film under the water and the stability of the superhydrophobic surface. The research supplies a new way of improving anti-scaling performance of superhydrophobic coating by incorporating the organic chelating agent at the interface and changing the traditional way of scale prevention.
Decoding Cortical Glial Cell Development
Authors: Li Xiaosu , Liu Guoping , Yang Lin , Li Zhenmeiyu , Zhang Zhuangzhi , Xu Zhejun , Cai Yuqun , Du Heng , Su Zihao , Wang Ziwu , Duan Yangyang , Chen Haotian , Shang Zicong , You Yan , Zhang Qi , He Miao , Chen Bin , Yang Zhengang 
Published: February 2021

AbstractMouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start to generate ASCL1+EGFR+ apical multipotent intermediate progenitors (MIPCs), which then differentiate into basal MIPCs that express ASCL1, EGFR, OLIG2, and MKI67. These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons. Finally, single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons. Taken together, this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes.
Clinicopathological predictors of postoperative upstaging to invasive ductal carcinoma (IDC) in patients preoperatively diagnosed with ductal carcinoma in situ (DCIS): a multi-institutional retrospective cohort study
Authors: Tanaka Kiyo , Masuda Norikazu , Hayashi Naoki , Sagara Yasuaki , Hara Fumikata , Kadoya Takayuki , Matsui Akira , Miyazaki Chieko , Shien Tadahiko , Tokunaga Eriko , Hayashi Takako , Niikura Naoki , Maeda Shigeto , Komoike Yoshihumi , Bando Hiroko , Kanbayashi Chizuko , Iwata Hiroji 
Published: February 2021

Abstract
Background
We conducted a prospective study with the intention to omit surgery for patients with ductal carcinoma in situ (DCIS) of the breast. We aimed to identify clinicopathological predictors of postoperative upstaging to invasive ductal carcinoma (IDC) in patients preoperatively diagnosed with DCIS.

Patients and methods
We retrospectively analyzed patients with DCIS diagnosed through biopsy between April 1, 2010 and December 31, 2014, from 16 institutions. Clinical, radiological, and histological variables were collected from medical records.

Results
We identified 2,293 patients diagnosed with DCIS through biopsy, including 1,663 DCIS (72.5%) cases and 630 IDC (27.5%) cases. In multivariate analysis, the presence of a palpable mass (odds ratio [OR] 1.8; 95% confidence interval [CI] 1.2–2.6), mammography findings (≥ category 4; OR 1.8; 95% CI 1.2–2.6), mass formations on ultrasonography (OR 1.8; 95% CI 1.2–2.5), and tumor size on MRI (> 20 mm; OR 1.7; 95% CI 1.2–2.4) were independent predictors of IDC. Among patients with a tumor size on MRI of ≤ 20 mm, the possibility of postoperative upstaging to IDC was 22.1%. Among the 258 patients with non-palpable mass, nuclear grade 1/2, and positive for estrogen receptor, the possibility was 18.1%, even if the upper limit of the tumor size on MRI was raised to ≤ 40 mm.

Conclusion
We identified four independent predictive factors of upstaging to IDC after surgery among patients with DCIS diagnosed by biopsy. The combined use of various predictors of IDC reduces the possibility of postoperative upstaging to IDC, even if the tumor size on MRI is larger than 20 mm.
Auditory Phenotypic Variability in Friedreich’s Ataxia Patients
Authors: Koohi Nehzat , Thomas-Black Gilbert , Giunti Paola , Bamiou Doris-Eva 
Published: February 2021

AbstractAuditory neural impairment is a key clinical feature of Friedreich’s Ataxia (FRDA). We aimed to characterize the phenotypical spectrum of the auditory impairment in FRDA in order to facilitate early identification and timely management of auditory impairment in FRDA patients and to explore the relationship between the severity of auditory impairment with genetic variables (the expansion size of GAA trinucleotide repeats, GAA1 and GAA2), when controlled for variables such as disease duration, severity of the disease and cognitive status. Twenty-seven patients with genetically confirmed FRDA underwent baseline audiological assessment (pure-tone audiometry, otoacoustic emissions, auditory brainstem response). Twenty of these patients had additional psychophysical auditory processing evaluation including an auditory temporal processing test (gaps in noise test) and a binaural speech perception test that assesses spatial processing (Listening in Spatialized Noise-Sentences Test). Auditory spatial and auditory temporal processing ability were significantly associated with the repeat length of GAA1. Patients with GAA1 greater than 500 repeats had more severe auditory temporal and spatial processing deficits, leading to poorer speech perception. Furthermore, the spatial processing ability was strongly correlated with the Montreal Cognitive Assessment (MoCA) score. To our knowledge, this is the first study to demonstrate an association between genotype and auditory spatial processing phenotype in patients with FRDA. Auditory temporal processing, neural sound conduction, spatial processing and speech perception were more severely affected in patients with GAA1 greater than 500 repeats. The results of our study may indicate that auditory deprivation plays a role in the development of mild cognitive impairment in FRDA patients.
History and Current Status of Sugarcane Breeding, Germplasm Development and Molecular Genetics in Brazil
Authors: Cursi D. E. , Hoffmann H. P. , Barbosa G. V. S. , Bressiani J. A. , Gazaffi R. , Chapola R. G. , Fernandes Junior A. R. , Balsalobre T. W. A. , Diniz C. A. , Santos J. M. , Carneiro M. S. 
Published: February 2021

AbstractBrazil is the world’s largest producer of sugarcane and one of the leading suppliers of sugar and ethanol worldwide. In the 2019–2020 crop season, the country produced 642.7 million tons of sugarcane in a harvest area of 8.44 million hectares. Historically, sugarcane breeding has contributed continuously to increasing yields by regularly releasing superior cultivars for use by the Brazilian industry. In the last 40 years, an average annual increase of 155.7 kg ha−1 of sugar yield has been reported, about half of which may be attributed to breeding programs. However, due to the size of the country, the intensive expansion of the crop to low-fertility soils in the last few years, especially in degraded pasture areas, and the widespread adoption of mechanization, new challenges have been imposed on national breeding programs. This review covers the current situation with sugarcane breeding in Brazil and the main advances that have allowed the country to maintain world leadership in developing the industry. Additionally, the history of sugarcane breeding, current national breeding institutions, germplasm development, key breeding objectives, selection stages and methodologies are summarized. An overview is also presented of biotechnological approaches which have become key tools for improving Brazilian traditional breeding programs. The adoption of strategies to increase Brazilian sugarcane yield, aiming to consolidate crop production in a food and energy matrix, is also discussed.
PeppeRecycle: Improving Children’s Attitude Toward Recycling by Playing with a Social Robot
Authors: Castellano Giovanna , De Carolis Berardina , D’Errico Francesca , Macchiarulo Nicola , Rossano Veronica 
Published: February 2021

AbstractIn this paper, we investigate the use of a social robot as an engaging interface of a serious game intended to make children more aware and well disposed towards waste recycle. The game has been designed as a competition between the robot Pepper and a child. During the game, the robot simultaneously challenges and teaches the child how to recycle waste materials. To endow the robot with the capability to play as a game opponent in a real-world context, it is equipped with an image recognition module based on a Convolutional Neural Network to detect and classify the waste material as a child would do, i.e. by simply looking at it. A formal experiment involving 51 primary school students is carried out to evaluate the effectiveness of the game in terms of different factors such as the interaction with the robot, the users’ cognitive and affective dimensions towards ecological sustainability, and the propensity to recycle. The obtained results are encouraging and draw promising scenarios for educational robotics in changing children’s attitudes toward recycling. Indeed Pepper turns out to be positively evaluated by children as a trustful and believable companion and this allows children to be concentrated on the “memorization” task during the game. Moreover, the use of real objects as waste items during the game turns out to be a successful approach not only for perceived learning effectiveness but also for the children’s engagement.