bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBELAJARAN ONLINE BERBASIS PROYEK PADA MATA PELAJARAN BAHASA INGGRIS DITENGAH PANDEMI COVID-19
Authors: Suci Lestari  
Published: November 2021

Situasi pandemi pada saat ini menyebabkan beberapa perubahan yang merubah tatanan hidup, termasuk di bidang pendidikan. Sehingga semua tingkat pendidikan "dipaksa" beralih untuk beradaptasi dengan drastis dalam melaksanakan pembelajaran bahasa inggris di rumah melalui media online. Penelitian ini bertujuan untuk menjabarkan secara teoritis dengan menggunakan kajian kepustakaan terkait pembelajaran online berbasis proyek pada pembelajaran bahasa inggris di era pandemi Covid-19 yang berdampak pada sistem belajar dari rumah. Sistem pembelajaran online berbasis proyek pelajar diberikan keleluasaan untuk mengakses materi pembelajaran bahasa inggris melalui internet. Pendidik dan peserta didik dapat mengakses banyak platform maupun media online melalui jaringan internet. Beberapa hal yang menjadi kendala dalam penerapan pembelajaran online antara lain terbatasnya kuota internet, dan pendidik serta peserta didik yang tidak terbiasa dengan penerapan pembelajaran online.
Kata kunci: Pembelajaran Online, Pembelajaran Bahasa Inggris, Pembelajaran Berbasis Proyek, pandemi Covid-19
PELUANG DAN TANTANGAN JURNALISME PERJALANAN DALAM MENGKOMUNIKASIKAN PARIWISATA
Authors: Wardaningsih Agustin Diana 
Published: November 2021

Jurnalisme Perjalanan merupakan salah satu perkembangan jurnalistik masa kini. Jurnalisme Perjalanan adalah kegiatan mengumpulkan, mengemas, dan menyampaikan informasi tentang perjalanan ke suatu lokasi atau daerah kepada masyarakat. Di dalam definisi tersebut, salah satunya adalah pariwisata atau tourism yaitu perjalanan yang dilakukan untuk rekreasi atau liburan. Berkembangnya industri pariwisata meningkatkan kebutuhan akan komunikasi pariwisata sebagai salah satu aktivitas manusia dalam menyampaikan informasi tentang perjalanan ke suatu daerah atau obyek wisata. Selama ini kegiatan komunikasi pariwisata dilakukan sebagai sarana promosi obyek wisata sehingga membuat orang tertarik untuk berkunjung. Namun sering melupakan kelengkapan infrastruktur dan kesiapan masyarakat setempat untuk menerima kunjungan wisatawan. Inilah yang menjadi salah satu tugas dan tanggungjawab jurnalisme perjalanan untuk memberikan gambaran yang utuh dan lengkap sesuai fakta dan data di lapangan terkait dengan tempat atau obyek wisata tertentu. Penelitian ini merupakan studi literatur dengan mencari referensi teori dan konsep – konsep yang relevan untuk menjawab permasalahan yang ada,menghimpun data serta sumber yang berhubungan dengan topik yang diangkat melalui jurnal, buku, dokumentasi, internet, dll. Tantangan bagi Jurnalisme perjalanan dalam mengkomunikasikan pariwisata di Indonesia datang bukan saja dari industri pariwisatanya, melainkan dari dalam industri media sendiri, salah satunya apabila jurnalisme perjalanan masuk dalam ranah komersialisasi. Masih banyak peluang yang ada, salah satunya beragam topik yang bisa dipilih dalam mengkomunikasikan pariwisata Indonesia dalam kerangka jurnalisme perjalanan.
Predicting Post-Therapeutic Visual Acuity and OCT Images in Patients With Central Serous Chorioretinopathy by Artificial Intelligence
Authors: Xu Fabao , Wan Cheng , Zhao Lanqin , Liu Shaopeng , Hong Jiaming , Xiang Yifan , You Qijing , Zhou Lijun , Li Zhongwen , Gong Songjian , Zhu Yi , Chen Chuan , Zhang Li , Gong Yajun , Li Longhui , Li Cong , Zhang Xiayin , Guo Chong , Lai Kunbei , Huang Chuangxin , Ting Daniel , Lin Haotian , Jin Chenjin 
Published: November 2021

To predict visual acuity (VA) and post-therapeutic optical coherence tomography (OCT) images 1, 3, and 6 months after laser treatment in patients with central serous chorioretinopathy (CSC) by artificial intelligence (AI). Real-world clinical and imaging data were collected at Zhongshan Ophthalmic Center (ZOC) and Xiamen Eye Center (XEC). The data obtained from ZOC (416 eyes of 401 patients) were used as the training set; the data obtained from XEC (64 eyes of 60 patients) were used as the test set. Six different machine learning algorithms and a blending algorithm were used to predict VA, and a pix2pixHD method was adopted to predict post-therapeutic OCT images in patients after laser treatment. The data for VA predictions included clinical features obtained from electronic medical records (20 features) and measured features obtained from fundus fluorescein angiography, indocyanine green angiography, and OCT (145 features). The data for OCT predictions included 480 pairs of pre- and post-therapeutic OCT images. The VA and OCT images predicted by AI were compared with the ground truth. In the VA predictions of XEC dataset, the mean absolute errors (MAEs) were 0.074–0.098 logMAR (within four to five letters), and the root mean square errors were 0.096–0.127 logMAR (within five to seven letters) for the 1-, 3-, and 6-month predictions, respectively; in the post-therapeutic OCT predictions, only about 5.15% (5 of 97) of synthetic OCT images could be accurately identified as synthetic images. The MAEs of central macular thickness of synthetic OCT images were 30.15 ± 13.28 μm and 22.46 ± 9.71 μm for the 1- and 3-month predictions, respectively. This is the first study to apply AI to predict VA and post-therapeutic OCT of patients with CSC. This work establishes a reliable method of predicting prognosis 6 months in advance; the application of AI has the potential to help reduce patient anxiety and serve as a reference for ophthalmologists when choosing optimal laser treatments.
The Association of Fatigue With Decreasing Regularity of Locomotion During an Incremental Test in Trained and Untrained Healthy Adults
Authors: Rabuffetti Marco , Steinach Mathias , Lichti Julia , Gunga Hanns-Christian , Balcerek Björn , Becker Philipp Nils , Fähling Michael , Merati Giampiero , Maggioni Martina Anna 
Published: November 2021

Fatigue is a key factor that affects human motion and modulates physiology, biochemistry, and performance. Prolonged cyclic human movements (locomotion primarily) are characterized by a regular pattern, and this extended activity can induce fatigue. However, the relationship between fatigue and regularity has not yet been extensively studied. Wearable sensor methodologies can be used to monitor regularity during standardized treadmill tests (e.g., the widely used Bruce test) and to verify the effects of fatigue on locomotion regularity. Our study on 50 healthy adults [27 males and 23 females; &lt;40 years; five dropouts; and 22 trained (T) and 23 untrained (U) subjects] showed how locomotion regularity follows a parabolic profile during the incremental test, without exception. At the beginning of the trial, increased walking speed in the absence of fatigue is associated with increased regularity (regularity index, RI, a. u., null/unity value for aperiodic/periodic patterns) up until a peak value (RI = 0.909 after 13.8 min for T and RI = 0.915 after 13.4 min for U subjects; median values, n. s.) and which is then generally followed (after 2.8 and 2.5 min, respectively, for T/U, n. s.) by the walk-to-run transition (at 12.1 min for both T and U, n. s.). Regularity then decreases with increased speed/slope/fatigue. The effect of being trained was associated with significantly higher initial regularity [0.845 (T) vs 0.810 (U),p &lt; 0.05 corrected], longer test endurance [23.0 min (T) vs 18.6 min (U)], and prolonged decay of locomotor regularity [8.6 min (T) vs 6.5 min (U)]. In conclusion, the monitoring of locomotion regularity can be applied to the Bruce test, resulting in a consistent time profile. There is evidence of a progressive decrease in regularity following the walk-to-run transition, and these features unveil significant differences among healthy trained and untrained adult subjects.
Open Science Expectations for Simulation-Based Research
Authors: Mullendore Gretchen L. , Mayernik Matthew S. , Schuster Douglas C. 
Published: November 2021

There is strong agreement across the sciences that replicable workflows are needed for computational modeling. Open and replicable workflows not only strengthen public confidence in the sciences, but also result in more efficient community science. However, the massive size and complexity of geoscience simulation outputs, as well as the large cost to produce and preserve these outputs, present problems related to data storage, preservation, duplication, and replication. The simulation workflows themselves present additional challenges related to usability, understandability, documentation, and citation. These challenges make it difficult for researchers to meet the bewildering variety of data management requirements and recommendations across research funders and scientific journals. This paper introduces initial outcomes and emerging themes from the EarthCube Research Coordination Network project titled “What About Model Data? - Best Practices for Preservation and Replicability,” which is working to develop tools to assist researchers in determining what elements of geoscience modeling research should be preserved and shared to meet evolving community open science expectations.Specifically, the paper offers approaches to address the following key questions:• How should preservation of model software and outputs differ for projects that are oriented toward knowledge production vs. projects oriented toward data production?• What components of dynamical geoscience modeling research should be preserved and shared?• What curation support is needed to enable sharing and preservation for geoscience simulation models and their output?• What cultural barriers impede geoscience modelers from making progress on these topics?
IL-18 Mediates Vascular Calcification Induced by High-Fat Diet in Rats With Chronic Renal Failure
Authors: Zhang Yinyin , Zhang Kun , Zhang Yuling , Zhou Lingqu , Huang Hui , Wang Jingfeng 
Published: November 2021

Objective: Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality in patients with chronic renal failure (CRF). It is well-known that obesity and metabolic syndrome (OB/MS) predicts poor prognosis of CRF patients. However, the influence of OB/MS on VC in CRF patients isn't clear. IL-18 mediates OB/MS-related inflammation, but whether IL-18 is involved in OB/MS -mediated VC in CRF patients hasn't been studied. In this study, it was explored that whether OB/MS caused by high-fat diet (HFD) can affect the level of serum IL-18 and aggravate the degree of VC in CRF rats. Furthermore, it was studied that whether IL-18 induces rat vascular smooth muscle cells (VSMCs) calcification by activating the MAPK pathways.Approach: The rats were randomly assigned to the sham-operated, CRF and CRF + HFD groups. CRF was induced by 5/6 nephrectomy. Serum IL-18 levels and aortic calcification indicators were compared in each group. Primary rat VSMCs calcification were induced by β-glycerophosphate and exposed to IL-18. VSMCs were also treated with MAPK inhibitors.Results: The weight, serum levels of hsCRP, TG and LDL-C in CRF + HFD group were significantly higher than those in sham-operated and CRF groups (p &lt; 0.05). Compared with the sham-operated group, the calcium content and the expression of BMP-2 of aorta in CRF and CRF + HFD groups were significantly increased (p &lt; 0.05). Moreover, the calcium content and the expression of BMP-2 of aorta in CRF + HFD group was significantly higher than those in CRF group (p &lt; 0.05). And the serum IL-18 level was positively correlated with aortic calcium content. It was also found that p38 inhibitor SB203580 can suppress the VSMCs calcification and osteoblast phenotype differentiation induced by IL-18. But the JNK inhibitor SP600125 can't suppress the VSMCs calcification and osteoblast phenotype differentiation induced by IL-18.Conclusions: These findings suggest that obesity-related inflammation induced by high-fat diet could exacerbate VC in CRF rats. Furthermore, serum IL-18 level had a positive correlation with the degree of VC. It is also found that IL-18 promoted osteogenic differentiation and calcification of rat VSMCs via p38 pathway activation.
Incidence and Characterization of Concealed Cardiac Amyloidosis Among Unselected Elderly Patients Undergoing Post-mortem Examination
Authors: Porcari Aldostefano , Bussani Rossana , Merlo Marco , Varrà Guerino Giuseppe , Pagura Linda , Rozze Davide , Sinagra Gianfranco 
Published: November 2021

Background: The prevalence of cardiac amyloidosis (CA) is unknown.Aims and Methods: We sought to (a) determine the prevalence of CA in unselected patients ≥75 years undergoing autopsy, (b) characterize cardiological profiles of CA and non-CA patients by providing clinical-histological correlations, and (c) compare their cardiological profiles. After dedicated staining, the localization (interstitial or vascular) and the distribution (non-diffuse or diffuse) of amyloid deposition were analyzed. Cardiological data at last evaluation were retrospectively assessed for the presence of CA red-flags.Results: CA (50% light chains, 50% transthyretin) was found in 43% (n = 24/56) of the autopsied hearts. Atria were involved in 96% of cases. Amyloid localized both at the perivascular and interstitial levels (95.5 and 85%, respectively) with a slightly predominant non-diffuse distribution (58% of cases). Compared to the other patients, CA patients had a more frequent history of heart failure (HF) (79 vs. 47%, p = 0.014), advanced NYHA functional class (III-IV 25 vs. 6%, p = 0.047), atrial fibrillation (68 vs. 36%, p = 0.019), discrepancy between QRS voltage and left ventricular (LV) thickness (70 vs. 12%, p &lt; 0.001), thicker LV walls (15 vs. 11 mm, p &lt; 0.001), enlarged left atrium (49 vs. 42 mm, p = 0.019) and restrictive filling pattern (56 vs. 19%, p = 0.020). The presence of right ventricular amyloidosis seemed to identify hearts with a higher amyloid burden. Among the CA patients, &gt;30% had ≥3 echocardiographic red-flags of disease.Conclusion: CA can be found in 43% of autopsied hearts from patients ≥75 years old, especially in patients with HF, LV hypertrophy and atrial fibrillation.
Cardiac Care of Non-COVID-19 Patients During the SARS-CoV-2 Pandemic: The Pivotal Role of CCTA
Authors: Conte Edoardo , Mushtaq Saima , Mancini Maria Elisabetta , Annoni Andrea , Formenti Alberto , Muscogiuri Giuseppe , Gaudenzi Asinelli Margherita , Gigante Carlo , Collet Carlos , Sonck Jeroen , Guglielmo Marco , Baggiano Andrea , Cosentino Nicola , Denora Marialessia , Belmonte Marta , Agalbato Cecilia , Esposito Andrea Alessandro , Assanelli Emilio , Bartorelli Antonio L. , Pepi Mauro , Pontone Gianluca , Andreini Daniele 
Published: November 2021

Aim: The aim of this study is to evaluate the potential use of coronary CT angiography (CCTA) as the sole available non-invasive diagnostic technique for suspected coronary artery disease (CAD) during the coronavirus disease 2019 (COVID-19) pandemic causing limited access to the hospital facilities.Methods and Results: A consecutive cohort of patients with suspected stable CAD and clinical indication to non-invasive test was enrolled in a hub hospital in Milan, Italy, from March 9 to April 30, 2020. Outcome measures were obtained as follows: cardiac death, ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina. All the changes in medical therapy following the result of CCTA were annotated. A total of 58 patients with a mean age of 64 ± 11 years (36 men and 22 women) were enrolled. CCTA showed no CAD in 14 patients (24.1%), non-obstructive CAD in 30 (51.7%) patients, and obstructive CAD in 14 (24.1%) patients. Invasive coronary angiography (ICA) was considered deferrable in 48 (82.8%) patients. No clinical events were recorded after a mean follow-up of 376.4 ± 32.1 days. Changes in the medical therapy were significantly more prevalent in patients with vs. those without CAD at CCTA.Conclusion: The results of the study confirm the capability of CCTA to safely defer ICA in the majority of symptomatic patients and to correctly identify those with critical coronary stenoses necessitating coronary revascularization. This characteristic could be really helpful especially when the hospital resources are limited
Retrospective Analysis and Forecasted Economic Impact of a Virtual Cardiac Rehabilitation Program in a Third-Party Payer Environment
Authors: Harzand Arash , Weidman Aaron C. , Rayl Kenneth R. , Adesanya Adelanwa , Holmstrand Ericka , Fitzpatrick Nicole , Vathsangam Harshvardhan , Murali Srinivas 
Published: November 2021

Background: Participation in cardiac rehabilitation (CR) is recommended for all patients with coronary artery disease (CAD) following hospitalization for acute coronary syndrome or stenting. Yet, few patients participate due to the inconvenience and high cost of attending a facility-based program, factors which have been magnified during the ongoing COVID pandemic. Based on a retrospective analysis of CR utilization and cost in a third-party payer environment, we forecasted the potential clinical and economic benefits of delivering a home-based, virtual CR program, with the goal of guiding future implementation efforts to expand CR access.Methods: We performed a retrospective cohort study using insurance claims data from a large, third-party payer in the state of Pennsylvania. Primary diagnostic and procedural codes were used to identify patients admitted for CAD between October 1, 2016, and September 30, 2018. Rates of enrollment in facility-based CR, as well as all-cause and cardiovascular hospital readmission and associated costs, were calculated during the 12-months following discharge.Results: Only 37% of the 7,264 identified eligible insured patients enrolled in a facility-based CR program within 12 months, incurring a mean delivery cost of $2,922 per participating patient. The 12-month all-cause readmission rate among these patients was 24%, compared to 31% among patients who did not participate in CR. Furthermore, among those readmitted, CR patients were readmitted less frequently than non-CR patients within this time period. The average per-patient cost from hospital readmissions was $30,814 per annum. Based on these trends, we forecasted that adoption of virtual CR among patients who previously declined CR would result in an annual cost savings between $1 and $9 million in the third-party healthcare system from a combination of increased overall CR enrollment and fewer hospital readmissions among new HBCR participants.Conclusions: Among insured patients eligible for CR in a third-party payer environment, implementation of a home-based virtual CR program is forecasted to yield significant cost savings through a combination of increased CR participation and a consequent reduction in downstream healthcare utilization.
Gabbro Discovery in Discovery Deep: First Plutonic Rock Samples From the Red Sea Rift Axis
Authors: Follmann Jörg , van der Zwan Froukje M. , Preine Jonas , Hübscher Christian , Bousquet Romain , Augustin Nico 
Published: November 2021

Plutonic rocks such as gabbros provide information on magmatic and tectonic processes which occur beneath a mid-ocean rift axis as well as on the formation of the oceanic crust. Igneous rocks, reported from the Red Sea Rift valley, have been limited to extrusive basalts so far. The only deeper crustal rocks found in the Red Sea area are from the rift flanks and are interpreted as late-stage continental rift magmatism. Here, we present the geochemistry of the first recovered gabbro fragments from the axis of the Red Sea Rift, sampled from a crater structure within the brine-filled Discovery Deep at the axis of the Red Sea Rift. Petrology and geochemistry show characteristics of a typical mid-ocean ridge gabbro formed at shallow crystallization depth. Clinopyroxene core mineral data fall within two groups, thus pointing to a multiphased magmatic history, including different magma batches and a joint late-stage fractional crystallization. Geobarometry, based on clinopyroxene cores, suggests lower crystallization pressures than similar geobarometric data reported for gabbroic samples from Zabargad (8–9 kbar) and Brother’s Islands (2.5–3.5 kbar) at the rift flanks. However, based on the evolved whole rock composition, its multiphase history, the thickness of the crust, the current location of the samples, and the uncertainties in the barometer, geobarometric estimates for the samples are likely overestimated. Instead, we propose that these rock fragments originate from the upper part of a fully developed oceanic crust in the central Red Sea Rift. High-resolution bathymetry and sparker seismic data reveal that the Discovery Deep is characterized by a significant normal fault and a strong reflector near the rift axis, which we interpret as a potential sill intrusion in an approximate depth of 400 m. Based on the lack of progressive alteration and the sampling location within a sediment-free crater structure, we interpret that the emplacement of the gabbros has to be geologically recent. We interpret the gabbro either as a xenolith transported by the eruptive volcanism that formed the crater, potentially related to the sill intrusion visible at depth, or as intrusive gabbro, which was uplifted and deposited in a talus fan by the adjacent normal fault, exposed by the formation of the volcanic crater.
Pastoralism and Millet Cultivation During the Bronze Age in the Temperate Steppe Region of Northern China
Authors: Zhang Yaping , Zhang Ying , Hu Songmei , Zhou Xinying , Liu Linjing , Liu Junchi , Zhao Keliang , Li Xiaoqiang 
Published: November 2021

Eastern and Western Asia were important centers for the domestication of plants and animals and they developed different agricultural practices and systems. The timing, routeway and mechanisms of the exchanges between the two centers have long been important scientific issues. The development of a mixed pastoral system (e.g., with the rearing of sheep, goats and cattle) and millet cultivation in the steppe region of northern China was the result of the link between the two cultures. However, little detailed information is available about the precise timing and mechanisms involved in this mixture of pastoralism and millet cultivation. To try to address the issue, we analyzed the pollen, fungal spores and phytolith contents of soil samples from the Bronze Age Zhukaigou site in the steppe area of North China, which was combined with AMS 14C dating of charcoal, millet and animal bones. A mixed pastoralism and millet agricultural system appeared at the site between 4,000 and 3,700 cal yr BP, and the intensity of animal husbandry increased in the later stage of occupation. Published data indicate that domestic sheep/goats appeared across a wide area of the steppe region of northern China after ∼4,000 cal yr BP. A comparison of records of sheep/goat rearing and paleoclimatic records from monsoon area in China leads us to conclude that the mixture of pastoralism and millet cultivation was promoted by the occurrence of drought events during 4,200–4,000 cal yr BP. Moreover, we suggest that mixed rainfed agriculture and animal husbandry increased the adaptability and resilience of the inhabitants of the region which enabled them to occupy the relatively arid environment of the monsoon marginal area of northern China.