bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrative multilevel review of thriving at work: Assessing progress and promise
Authors: Goh Zen , Eva Nathan , Kiazad Kohyar , Jack Gavin A. , De Cieri Helen , Spreitzer Gretchen M. 
Published: October 2021

SummaryThriving at work is a notable construct given its role in individual health and developmental outcomes. According to the Socially Embedded Model of Thriving (SEMT), individuals thrive at work when embedded in environments that support agentic behaviors and can self‐sustain this state through positive spirals of agentic behaviors, resources, and thriving. The SEMT is inherently multilevel, yet there are two unarticulated but critical multilevel issues in existing scholarship: a paucity of research reflecting these multilevel features of the SEMT and an incipient multilevel conceptualization of thriving that has little theoretical justification. As a catalyst for progress, we present an integrative review drawing from the SEMT and other supplementary theoretical perspectives to define a multilevel conceptualization of thriving at work. Through this lens, we organize, synthesize, and evaluate the body of evidence, integrating the multilevel view of thriving within established scholarship. To substantiate our framework theoretically, we articulate how lower level processes unfold to develop higher level collective manifestations of thriving at work. We identify opportunities for theoretical and empirical advancement, coupled with specific, actionable recommendations, to deepen a multilevel conceptualization of thriving. Altogether, we advance thriving at work as a multilevel construct meaningful at three levels—individuals, dyads, and collectives.
The cross‐level moderating effect of team task support on the nonlinear relationship between proactive personality and employee reflective learning
Authors: Yang Huadong , van der Heijden Beatrice , Shipton Helen , Wu Chiahuei 
Published: October 2021

SummaryReflective learning is a fundamental part of human learning and development and has attracted attention from management scholars as well as practitioners. In this study, we build on trait activation theory and investigate how proactive personality and team task support jointly influence employee reflective learning. Using a questionnaire survey, we collected data at two time points from 154 participants nested in 37 teams in five organizations in the United Kingdom. The results from multilevel analyses showed that proactive personality had a positive effect on reflective learning up to a certain point. Over and above this inflection point, this positive effect ceased to further increase. In addition, the nonlinear effect of proactive personality on reflective learning was much stronger when team task support was weak than when it was strong. The finding regarding the nonlinear relationship extends our understanding of the effect of proactive personality. The cross‐level moderating effect of team task support suggests a complementary perspective to appreciate the interactions between proactive personality and its relevant situational characteristics. Practitioners can use these findings to design effective intervention plans and facilitate employee reflective learning in specific settings and in workplace learning in general.
Polyurea Modified with 4‐Dihydropyrimidone‐2‐ketone Rings by Biginelli Reaction and its Boostered AIE Characteristic
Authors: Zhang Da , Zheng Jinxin , Zhang Pengfei , Zhao Ronghui , Chen Zhuo , Wang Meng , Deng Kuilin 
Published: October 2021

AbstractIn the synthesis of traditional AIE‐active polymers with conjugate or multi‐benzene system, the troublesome process is still faced such as consuming time, high temperature, catalysis, no water or vacuum, and so on. In this study, the polydihydropyrimidone derivatives (PDPMDs) with AIE properties are facilely synthesized by the introduction of 4‐dihydropyrimidone rings onto non‐AIE‐active intermediate polyureas (PUs) in Biginelli reaction. It is found that the unsymmetrical L‐lysine ethyl diisocyanate and butylenediamine played a very important role in the smooth preparation and fluorescence enhancement of PDPMDs. Compared with the intermediate PUs, the fluorescence of PDPMDs is significantly enhanced (35‐fold increase), which is mainly due to the intramolecular aggregation of dihydropyrimidone rings on PUs chains. At the same time, with the increase of the content of dihydropyrimidone rings, the fluorescence intensity of PDPMDs also increases, and the emission wavelength shows an obvious red shift. The fluorescence of PDPMDs also showed obvious dependence on excitation wavelength, which further reveals the clusterization‐triggering emission (CTE) mechanism. In summary, the strategy of endowing AIE properties to non‐AIE active polymer by introducing heterocycles into the backbone through multi‐component reaction provides useful guidance for AIE functionalization of other non‐AIE materials.
Reducing systematic errors due to deformation of organs at risk in radiotherapy
Authors: Rørtveit Øyvind Lunde , Hysing Liv Bolstad , Stordal Andreas Størksen , Pilskog Sara 
Published: October 2021

AbstractPurposeIn radiotherapy (RT), the planning CT (pCT) is commonly used to plan the full RT‐course. Due to organ deformation and motion, the organ shapes seen at the pCT will not be identical to their shapes during RT. Any difference between the pCT organ shape and the organ's mean shape during RT will cause systematic errors. We propose to use statistical shrinkage estimation to reduce this error using only the pCT and the population mean shape computed from training data.MethodsThe method was evaluated for the rectum in a cohort of 37 prostate cancer patients that had a pCT and 7–10 treatment CTs with rectum delineations. Deformable registration was performed both within‐patient and between patients, resulting in point‐to‐point correspondence between all rectum shapes, which enabled us to compute a population mean rectum. Shrinkage estimates were found by combining the pCTs linearly with the population mean.The method was trained and evaluated using leave‐one‐out cross validation. The shrinkage estimates and the patient mean shapes were compared geometrically using the Dice similarity index (DSI), Hausdorff distance (HD), and bidirectional local distance. Clinical dose/volume histograms, equivalent uniform dose (EUD) and minimum dose to the hottest 5% volume (D5%) were compared for the shrinkage estimate and the pCT.ResultsThe method resulted in moderate but statistically significant increase in similarity to the patient mean shape over the pCT. On average, the HD was reduced from 15.6 to 13.4 mm, while the DSI was increased from 0.74 to 0.78. Significant reduction in the bias of volume estimates was found in the DVH‐range of 52.5–65 Gy, where the bias was reduced from −1.3 to −0.2 percentage points, but no significant improvement was found in EUD or D5%,ConclusionsThe results suggest that shrinkage estimation can reduce systematic errors due to organ deformations in RT. The method has potential to increase the accuracy in RT of deformable organs and can improve motion modeling.
Screening for von Willebrand disease does not impact posttonsillectomy bleeding in a low‐risk population
Authors: Digiandomenico Stefanie , Conley Stephen F. , Johnson Victoria P. , Christopherson Pamela A. , Haberichter Sandra L. , Zhang Jian , Simpson Pippa , Abshire Thomas C. , Montgomery Robert R. , Flood Veronica H. 
Published: October 2021

AbstractBackgroundBleeding is an important complication in children following tonsillectomy. Screening with coagulation tests prior to procedure is common to assess bleeding risk in the perioperative period, although ASH/ASPHO Choosing Wisely guidelines recommend against routine PT/PTT testing. Our aim was to compare von Willebrand factor antigen (VWF:Ag) and activity levels among patients with postoperative bleeding following tonsillectomy to evaluate for potential risk for bleeding.ProcedureEligible subjects were aged 0–18 without significant personal or family history of major bleeding. Postoperative bleeding diaries were collected and symptoms measured using a postoperative bleeding score. Plasma VWF levels were drawn at time of anesthesia administration.ResultsPostoperative bleeding occurred in 248 cases out of 1399 total subjects. Median VWF:Ag was 86 in patients with postoperative bleeding scores of 1–2, 86 for scores 3–4, 84 for scores 5–6, and 83 for scores >6, with no significant difference among groups (p = .98). Additionally, no difference was observed for subjects with multiple days of postoperative bleeding as compared to those with only 1 day of postoperative bleeding. Finally, no difference in VWF:Ag was observed for subjects whose first reported bleed occurred early in the postoperative course compared to those whose first reported bleed occurred later. VWF:Ag does not correlate with severity of bleeding, time of onset of first bleeding event, or recurrence of bleeding in healthy children with no personal or family history of bleeding who have postoperative bleeding following tonsillectomy.ConclusionsThis data does not support routine von Willebrand disease screening prior to tonsillectomy.
Long‐term health‐related quality of life in young childhood cancer survivors and their parents
Authors: Fardell Joanna E. , Wakefield Claire E. , De Abreu Lourenco Richard , Signorelli Christina , McCarthy Maria , McLoone Jordana , Osborn Michael , Gabriel Melissa , Anazodo Antoinette , Alvaro Frank , Lockwood Liane , Walwyn Thomas , Skeen Jane , Tillemans Ramon , Cohn Richard J. ,   ANZCHOG Survivorship Group
Published: October 2021

AbstractPurposeFew studies have investigated the health‐related quality of life (HRQoL) of young childhood cancer survivors and their parents. This study describes parent and child cancer survivor HRQoL compared to population norms and identifies factors influencing child and parent HRQoL.MethodsWe recruited parents of survivors who were currently <16 years, and >5 years postdiagnosis. Parents reported on their child's HRQoL (Kidscreen‐10), and their own HRQoL (EQ‐5D‐5L). Parents rated their resilience and fear of cancer recurrence and listed their child's cancer‐related late effects.ResultsOne hundred eighty‐two parents of survivors (mean age = 12.4 years old and 9.7 years postdiagnosis) participated. Parent‐reported child HRQoL was significantly lower than population norms (48.4 vs. 50.7, p < .009). Parents most commonly reported that their child experienced sadness and loneliness (18.1%). Experiencing more late effects and receiving treatments other than surgery were associated with worse child HRQoL. Parents’ average HRQoL was high (0.90) and no different to population norms. However 38.5% of parents reported HRQoL that was clinically meaningfully different from perfect health, and parents experienced more problems with anxiety/depression (43.4%) than population norms (24.7%, p < .0001). Worse child HRQoL, lower parent resilience, and higher fear of recurrence was associated with worse parent HRQoL.ConclusionsParents report that young survivors experience small but significant ongoing reductions in HRQoL. While overall mean levels of HRQoL were no different to population norms, a subset of parents reported HRQoL that was clinically meaningfully different from perfect health. Managing young survivors’ late effects and improving parents’ resilience through survivorship may improve HRQoL in long‐term survivorship.
Association between weight change and remission of type 2 diabetes: a retrospective cohort study in primary care
Authors: Dambha‐Miller Hajira , Hounkpatin Hilda , Stuart Beth , Farmer Andrew 
Published: October 2021

AbstractThe purpose of this study was to quantify the association between weight change and the likelihood of remission of type 2 diabetes in a population‐based cohort without intensive interventions.We undertook a retrospective analysis of adults with type 2 diabetes registered across 150 primary care practices in Southern England, United Kingdom, within the electronic Care and Health Information Analytics (CHIA) database between 2013 and 2020. Stepwise mixed logistic models were constructed to examine the association between percentage weight change over five‐years, and the likelihood of remission in the subsequent two years using four categories: weight gain ≥2.5%; weight loss ≤2.5–5% or ≥5–10% or ≥10%.The study cohort included 56,120 people with type 2 diabetes with a mean (SD) disease duration of 8.0 (6.7) years. In total, 17,035 (30.4%) had microvascular complications and 10,661 (19.0%) had macrovascular complications. A total of 19.4% (10,896) lost ≥10% of their baseline weight with 1646 (15.1%) of these achieving remission. Overall, those who lost ≥10% in weight had a significantly higher likelihood of remission in both unadjusted and adjusted models; RR 1.53 (95% CI 1.40–1.68); and RR 1.51 (95% CI 1.37–1.66), respectively. Remission was still achievable but less likely among younger men with a longer diabetes duration (≥5 years), higher baseline HbA1c level, or pre‐existing microvascular or macrovascular complications.It was concluded weight loss of >10% is associated with remission of type 2 diabetes even among those with advanced disease and established microvascular or macrovascular complications. Our findings could motivate people with diabetes to lose weight in order to increase likelihood of remission. Copyright © 2021 John Wiley & Sons.
Synergistic effects of cellulose nanocrystals‐organic montmorillonite as hybrid nanofillers for enhancing mechanical, crystallization, and heat‐resistant properties of three‐dimensional printed poly(lactic acid) nanocomposites
Authors: Liu Hao , Zhang Bao , Zhou Laihong , Li Jinbo , Zhang Jiacheng , Chen Xiao , Xu Shunjian , He Hui 
Published: October 2021

AbstractCellulose nanocrystals (CNC)‐organic montmorillonite (OMMT) hybrid nanofillers were prepared, and their effects in reinforcing the performance of three‐dimensional (3D) printed poly(lactic acid) (PLA) nanocomposites were studied. The results indicated that the hybrid CNC‐OMMT nanofillers had a synergistic impact on enhancing the mechanical properties of PLA nanocomposites compared to either single nanofillers (CNC or OMMT). The dispersion of CNC‐OMMT in the PLA matrix was not only significantly improved, but also the hybrid nanofillers did not form pore defects in the nanocomposites. In terms of the crystallization performance, the multidimensional hybrid nanofillers acted as efficient heterogeneous‐nucleating agents and increased the PLA crystallization rate. Additionally, the incorporation of the hybrid nanofillers improved the heat resistance of the PLA nanocomposites when the printing platform temperature was adjusted to a temperature within the crystallization temperature range of PLA. The preparation of hybrid nanofillers based on existing nanomaterials and their incorporation into polymers creates a novel route for the development of high‐performance polymer nanocomposites.
Elevated acute phase proteins affect pharmacokinetics in COVID‐19 trials: Lessons from the CounterCOVID ‐ imatinib study
Authors: Bartelink Imke H. , Bet Pierre M. , Widmer Nicolas , Guidi Monia , Duijvelaar Erik , Grob Bram , Honeywell Richard , Evelo Amanda , Tielbeek Ivo P. E. , Snape Sue D. , Hamer Henrike , Decosterd Laurent A. , Jan Bogaard Harm , Aman Jurjan , Swart Eleonora L. 
Published: October 2021

AbstractThis study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (COVID‐19). Total (bound + unbound) and unbound imatinib plasma concentrations obtained from 134 patients with COVID‐19 participating in the CounterCovid study and from an historical dataset of 20 patients with gastrointestinal stromal tumor (GIST) and 85 patients with chronic myeloid leukemia (CML) were compared. Total imatinib area under the concentration time curve (AUC), maximum concentration (Cmax) and trough concentration (Ctrough) were 2.32‐fold (95% confidence interval [CI] 1.34–3.29), 2.31‐fold (95% CI 1.33–3.29), and 2.32‐fold (95% CI 1.11–3.53) lower, respectively, for patients with CML/GIST compared with patients with COVID‐19, whereas unbound concentrations were comparable among groups. Inclusion of alpha1‐acid glycoprotein (AAG) concentrations measured in patients with COVID‐19 into a previously published model developed to predict free imatinib concentrations in patients with GIST using total imatinib and plasma AAG concentration measurements (AAG‐PK‐Model) gave an estimated mean (SD) prediction error (PE) of −20% (31%) for total and −7.0% (56%) for unbound concentrations. Further covariate modeling with this combined dataset showed that in addition to AAG; age, bodyweight, albumin, CRP, and intensive care unit admission were predictive of total imatinib oral clearance. In conclusion, high total and unaltered unbound concentrations of imatinib in COVID‐19 compared to CML/GIST were a result of variability in acute phase proteins. This is a textbook example of how failure to take into account differences in plasma protein binding and the unbound fraction when interpreting PK of highly protein bound drugs, such as imatinib, could lead to selection of a dose with suboptimal efficacy in patients with COVID‐19.
Study of a Selected Series of 3‐ and 4‐Arylcoumarins as Antifungal Agents against Dermatophytic Fungi: T. rubrum and T. mentagrophytes
Authors: Lopez Cisneros Carmen Lucía , Cazar Ramírez María Elena , Bailon‐Moscoso Natalia , Guardado Estela , Borges Fernanda , Uriarte Eugenio , Matos Maria João 
Published: October 2021

AbstractThe main etiological agents in dermatophytosis of human skin and nails are Trichophyton, in particular Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagrophytes). A new series of twenty‐three 3‐ and 4‐arylcoumarins was synthesized and the antifungal activities against clinical isolates of T. rubrum and T. mentagrophytes were evaluated. Sixteen out of twenty‐three molecules exhibited antifungal activity against one or both fungi strains. In some cases, the activity against T. rubrum has been comparable to fluconazole, one of the standards, being 8‐methoxy‐3‐(4’‐nitrophenyl)coumarin (16) the best compound within this series (minimum inhibitory concentration, MIC=6.25 μg/mL). The preliminary structure‐activity relationship study showed that the antifungal activity depends on the position and nature of the substitution patterns. The cytotoxicity of eleven compounds on D‐384 (astrocytoma), A‐549 (lung cancer) and RKO (colorectal cancer) cell lines was also performed. With the aim of deeply understand the potential of these molecules as hits to develop new drugs, the theoretical absorption, distribution, metabolism and excretion (ADME) properties of the active compounds were calculated.
The Abelian Higgs model under a gauge invariant looking glass: exploiting new Ward identities for gauge invariant operators and the Equivalence Theorem
Authors: Dudal D. , Peruzzo G. , Sorella S. P. 
Published: October 2021

Abstract
The content of two additional Ward identities exhibited by the U(1) Higgs model is exploited. These novel Ward identities can be derived only when a pair of local composite operators providing a gauge invariant setup for the Higgs particle and the massive vector boson is introduced in the theory from the beginning. Among the results obtained from the above mentioned Ward identities, we underline a new exact relationship between the stationary condition for the vacuum energy, the vanishing of the tadpoles and the vacuum expectation value of the gauge invariant scalar operator. We also present a characterization of the two-point correlation function of the composite operator corresponding to the vector boson in terms of the two-point function of the elementary gauge fields. Finally, a discussion on the connection between the cartesian and the polar parametrization of the complex scalar field is presented in the light of the Equivalence Theorem. The latter can in the current case be understood in the language of a constrained cohomology, which also allows to rewrite the action in terms of the aforementioned gauge invariant operators. We also comment on the diminished role of the global U(1) symmetry and its breaking.
Clinical Speech fMRI in Children and Adolescents
Authors: Krafft Hannah , Staudt Martin 
Published: October 2021

Abstract
Purpose
In patients with drug-resistant focal epilepsy, surgical resection is often the only treatment option to achieve long-term seizure control. Prior to brain surgery involving potential language areas, identification of hemispheric language dominance is crucial. Our group developed and validated a functional magnetic resonance imaging (fMRI) battery of four pediatric language tasks. The present study aimed at optimizing fMRI data acquisition and analysis using these tasks.

Methods
We retrospectively analyzed speech fMRI examinations of 114 neuropediatric patients (age range 5.8–17.8 years) who were examined prior to possible epilepsy surgery. In order to evaluate hemispheric language dominance, 1–4 language tasks (vowel identification task VIT, word-chain task WCT, beep-story task BST, synonym task SYT) were measured.

Results
Language dominance was classified using fMRI activation in the 13 validly lateralizing ROIs (VLR) in frontal, temporal and parietal lobes and cerebellum of the recent validation study from our group: 47/114 patients were classified as left-dominant, 34/114 as bilateral and 6/114 as right-dominant. In an attempt to enlarge the set of VLR, we then compared for each task agreement of these ROI activations with the classified language dominance. We found four additional task-specific ROIs showing concordant activation and activation in ≥ 10 sessions, which we termed validly lateralizing (VLRnew). The new VLRs were: for VIT the temporal language area and for SYT the middle frontal gyrus, the intraparietal sulcus and cerebellum. Finally, in order to find the optimal sequence of measuring the different tasks, we analyzed the success rates of single tasks and all possible task combinations. The sequence 1) VIT 2) WCT 3) BST 4) SYT was identified as the optimal sequence, yielding the highest chance to obtain reliable results even when the fMRI examination has to be stopped, e.g., due to lack of cooperation.

Conclusion
Our suggested task order together with the enlarged set of VLRnew may contribute to optimize pediatric speech fMRI in a clinical setting.
Paper-based aptamer-antibody biosensor for gluten detection in a deep eutectic solvent (DES)
Authors: Svigelj Rossella , Dossi Nicolò , Grazioli Cristian , Toniolo Rosanna 
Published: October 2021

AbstractPaper has been widely employed as cheap material for the development of a great number of sensors such as pregnancy tests, strips to measure blood sugar, and COVID-19 rapid tests. The need for new low-cost analytical devices is growing, and consequently the use of these platforms will be extended to different assays, both for the final consumer and within laboratories. This work describes a paper-based electrochemical sensing platform that uses a paper disc conveniently modified with recognition molecules and a screen-printed carbon electrode (SPCE) to achieve the detection of gluten in a deep eutectic solvent (DES). This is the first method coupling a paper biosensor based on aptamers and antibodies with the DES ethaline. Ethaline proved to be an excellent extraction medium allowing the determination of very low gluten concentrations. The biosensor is appropriate for the determination of gluten with a limit of detection (LOD) of 0.2 mg L−1 of sample; it can detect gluten extracted in DES with a dynamic range between 0.2 and 20 mg L−1 and an intra-assay coefficient of 10.69%. This approach can be of great interest for highly gluten-sensitive people, who suffer from ingestion of gluten quantities well below the legal limit, which is 20 parts per million in foods labeled gluten-free and for which highly sensitive devices are essential.
Graphical abstract