bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imperative to Build Network Security System and Speed Up the Future Network Construction
Authors: Wu Aiqun , Gao Zhangxing 
Published: January 2021

Abstract
Network security is a comprehensive discipline involving computer science, network technology, communication technology, cryptography, information security technology, applied mathematics, number theory, information theory and other disciplines. Network security is to protect the hardware, software and data in the network system from accidental or malicious damage, change, and disclosure. The system runs continuously and reliably and normally, and network services are not interrupted. Although network security in the future market prospect is very good, but the Internet structural defects are known, because in the past nearly 20 years of rapid development of Internet technology, the pioneers of the IT industry seems to be technology focuses on the network flexibility and ignore the security of the network, so, in the site after the loss of a large number of network attacks, network security technology becomes emergent vacuum in the information technology, for the maintenance of computer network system security maintenance, inspection and repair network vulnerabilities, virus protection, organized by the national high strength against network has serious threat to all countries in the world, In such an environment, the core technology, key infrastructure is the only rely on independent innovation, create a new network system, with the new architecture, a new design, new technology, new resources, new standard and new application to open up a new network space, the building has an independent sovereign and independent control system of network security, it is imperative to accelerate the future network development.
OLHAR O BIBLIOTECÁRIO DO PRESENTE, VISUALIZAR A BIBLIOTECA DO FUTURO: ALFA E ÔMEGA, CÂMBIOS QUE FAZEM UMA BIBLIOTECA ESCOLAR
Authors: Carvalho Sandra Maria Souza de , Silveira Rogério Zanon da , Miguel Marcelo Calderari 
Published: January 2021

Averiguar a representação do bibliotecário do presente e a biblioteca do futuro perante a Geração Alpha é um desafio provocador, envolve explorar nuances e compreender suas determinantes locais. O objetivo desse estudo é situar a imagem do bibliotecário do presente e a representação da biblioteca escolar do futuro, ambos os perfis comunicados na ótica dos novos nativos digitais. O método de análise parte da entrevista semiestruturada com os discentes Alphas da Umef Dr Tuffy Nader, na cidade de Vila Velha, ES. O roteiro de diagnóstico serve como instrumento para análise do Discurso do Sujeito Coletivo (DSC) e, visa pautar construtos como: i) o significado, a representação que define o Ser bibliotecário; e, ii) o prospectar de cenários para a nova biblioteca escolar do futuro. Logo, a abordagem é descritiva e analítica, fundamenta-se na análise de discurso com apoio tecnológico do software DSCSoft. Os resultados evidenciam novos tempos e hábitos para a biblioteca escolar e o profissional da informação; pauta os dilemas de utopias, distopia e retrotopia que a cultura digital e as tecnologias de informação geram. O trabalho destaca a necessidade permanente da inovação dos modernos profissionais da informação (MPI) na ambiência da biblioteca e fora dela, e diz que a missão profissional se pauta no conhecimento científico e tecnológico, alinhado a valores humanos, para o exercício pleno da cidadania, com ética.
Investigation of Adsorption Effect of Carbon Monoxide on Coniine:
A DFT Study
Authors: Shahab Siyamak , Sheikhi Masoome , Khaleghian Mehrnoosh , Murashko Marina , Ahmadianarog Mahin , Atroshko Mikhail 
Published: January 2021

:
For the first time in the present study, the non-bonded interaction of the Coniine (C8H17N) with carbon monoxide
(CO) was investigated by density functional theory (DFT/M062X/6-311+G*) in the gas phase and solvent water. The
adsorption of the CO over C8H17N was affected on the electronic properties such as EHOMO, ELUMO, the energy gap between
LUMO and HOMO, global hardness. Furthermore, chemical shift tensors and natural charge of the C8H17N and complex
C8H17N/CO were determined and discussed. According to the natural bond orbital (NBO) results, the molecule C8H17N and
CO play as both electron donor and acceptor at the complex C8H17N/CO in the gas phase and solvent water. On the other
hand, the charge transfer is occurred between the bonding, antibonding or nonbonding orbitals in two molecules C8H17N
and CO. We have also investigated the charge distribution for the complex C8H17N/CO by molecular electrostatic potential
(MEP) calculations using the M062X/6-311+G* level of theory. The electronic spectra of the C8H17N and complex
C8H17N/CO were calculated by time dependent DFT (TD-DFT) for investigation of the maximum wavelength value of the
C8H17N before and after the non-bonded interaction with the CO in the gas phase and solvent water. Therefore, C8H17N can
be used as strong absorbers for air purification and reduce environmental pollution.
A Review on Deep Learning Architecture and Methods for MRI Brain Tumour Segmentation
Authors: Angulakshmi M. , Deepa M. 
Published: January 2021

Background:
The automatic segmentation of brain tumour from MRI medical images is mainly covered in this
review. Recently, state-of-the-art performance is provided by deep learning-based approaches in the field of image
classification, segmentation, object detection, and tracking tasks.

Introduction:
The core feature deep learning approach is the hierarchical representation of features from images and thus
avoiding domain-specific handcrafted features.

Methods:
In this review paper, we have dealt with a Review of Deep Learning Architecture and Methods for MRI Brain
Tumour Segmentation. First, we have discussed basic architecture and approaches for deep learning methods. Secondly,
we have discussed the literature survey of MRI brain tumour segmentation using deep learning methods and its
multimodality fusion. Then, the advantages and disadvantages of each method analyzed and finally concluded the
discussion with the merits and challenges of deep learning techniques.

Results:
The review of brain tumour identification using deep learning.

Conclusion:
Techniques may help the researchers to have a better focus on it.
Intelligent Techniques Analysis for Glycosylation Site Prediction
Authors: Alkuhlani Alhasan , Gad Walaa , Roushdy Mohamed , Salem Abdel-Badeeh M. 
Published: January 2021

Background:
Glycosylation is one of the most common post-translation modifications (PTMs) in organism
cells. It plays important roles in several biological processes including cell-cell interaction, protein folding, antigen’s
recognition, and immune response. In addition, glycosylation is associated with many human diseases such as cancer,
diabetes and coronaviruses. The experimental techniques for identifying glycosylation sites are time-consuming, extensive
laboratory work, and expensive. Therefore, computational intelligence techniques are becoming very important for
glycosylation site prediction.

Objective:
This paper is a theoretical discussion of the technical aspects of the biotechnological (e.g.,
using artificial intelligence and machine learning) to digital bioinformatics research and intelligent biocomputing.
The computational intelligent techniques have shown efficient results for predicting Nlinked,
O-linked and C-linked glycosylation sites. In the last two decades, many studies have been conducted
for glycosylation site prediction using these techniques. In this paper, we analyze and compare a
wide range of intelligent techniques of these studies from multiple aspects. The current challenges and
difficulties facing the software developers and knowledge engineers for predicting glycosylation sites
are also included.

Method:
The comparison between these different studies is introduced including many criteria such as
databases, feature extraction and selection, machine learning classification methods, evaluation
measures and the performance results.

Results and Conclusions:
Many challenges and problems are presented. Consequently, more efforts are needed to get
more accurate prediction models for the three basic types of glycosylation sites.
Therapeutic Potential of Poncirin Against Numerous Human Health Complications: Medicinal Uses and Therapeutic Benefit of an Active Principle
of Citrus Species
Authors: Patel Dinesh Kumar 
Published: January 2021

:
Medicinal plants have been used in the indigenous system of medicine for the treatment of numerous human
health complications. Medicinal plants were used for the separation and isolation of pure phytochemical and some of the
best examples are tubocurarine, aspirin, morphine, digoxin, atropine, quinine and reserpine. Phytoconstituents are pure plant
derived natural chemical found to be present in the medicinal plants and examples are flavonoids, alkaloids and phenolic
compounds etc. In the modern medicine there is global growth of herbal medicines due to their nutrition, physical
effectiveness and pharmacological activities. Plants have been used in the traditional medicines and modern drug
discoveries program. In order to investigate the biological potential of poncirin in modern medicine, here different scientific
data have been analyzed in the present investigation through various literature sources. Detailed pharmacological activities
of poncirin were also investigated in the present investigation to reveal the medicinal properties of poncirin in the medicine
and other allied health sectors. Analytical techniques used for the isolation of poncirin from various medicinal plants have
been also presented in this study. Poncirin is a flavanone glycoside found to be present in the Poncirus trifoliata and Citrus
reticulate having bitter taste. Biological importance of poncirin for their anti-inflammatory activity through inhibition of
PGE2 and IL-6 production has been investigated in the scientific field. Biological importance of poncirin against bacterial,
viral infections, gastric disease and human gastric cancer has been investigated in the medicine. Pharmacological data
analysis revealed the biological application of poncirin against bone loss, inflammation, colitis, human gastric cancer,
gastritis, liver injury and alzheimer's disease. From the analysis of the presented scientific information of poncirin it was
found that poncirin have significant biological activities and health benefit in the modern health sectors for the treatment of
human health complications and could be used as a drug in the future.
Influence of Removable Denture Cleaning Agents on Adhesion of Oral Pathogenic Microflora In Vitro: A Randomized Controlled Trial
Authors: Volchkova I.R. , Yumashev A.V. , Borisov V.V. , Doroshina V.I. , Kristal E.A. , Repina S.I. 
Published: January 2021

Introduction:
Removable dentures are used by 20% of the population. These may be accompanied by denture stomatitis in 15-70% of patients. The choice of the optimal cleansing agent for removable dental prostheses is of high significance.

Aim:
The aim of our research was to study the influence of removable denture cleansing products on the adhesion of microorganisms and yeast.

Materials and Methods:
We manufactured 144 specimens of standardized round shape with a diameter of 10 mm from 4 types of modern polymeric materials used by prosthetic dentistry to produce removable dentures, 12 specimens of each material were placed into suspensions of bacterial cultures of Staphylococcus aureus, Escherichia coli, Candida albicans, then into “ClearaSept” (Test group 1), “Рrotefix active cleanser” (Test group 2), saline solution (Control group), followed by nutrient media. The adhesion index was calculated and analyzed.

Results:
There was no reliable lowering of adhesion index of Staphylococcus Aureus to all materials detected in Test group 1 (U=6, p>0.05 for Bio XS; U=8, p>0.05 for Dental D, Denotokeep Peek, Vertex Rapid Simplified). In Test group 2, the adhesion index of Staphylococcus Aureus reliably decreased to all materials compared to the Control group (U=0, p≤0.01). The adhesion index of Candida albicans and Escherichia coli to all materials in Test group 1 had a minor to moderate reliable reduction compared to the Control group (U=0, p≤0.01). Test group 2 showed a significant reliable decrease in Candida albicans and Escherichia coli adhesion index to all materials in comparison with the Control group (U=0, p≤0.01).

Conclusion:
The research showed an unreliable or minor and moderate reliable decrease in microorganisms adhesion index depending on the microorganism species after treatment of denture material specimens by antibacterial soap “ClearaSept” and a reliable significant decrease in microbial and yeast adhesion after application of Protefix active cleaner solution, which demonstrates a more significant antimicrobial effect in comparison to “ClearaSept” against Staphylococcus aureus, Escherichia coli, and Candida albicans.
Comparing Adjuvant Beta Radiation, Mitomycin C, and Conjunctival Autograft in Primary Pterygium Treatment, a Three-year Follow-up Study
Authors: Al-Salem Khalil M. , Saif Ahmad T.S. , Saif Passant S. 
Published: January 2021

Purpose:
To compare the recurrence rate of primary pterygium surgery after the adjuvant use of Beta radiation, Mitomycin C, and conjunctival autograft.

Methods:
180 eyes of 180 patients were included in the study. All cases had primary pterygium excision following the use of adjuvant therapy of Beta radiation or Mitomycin C (0.02% for 5 minutes) or conjunctival autograft. The study was conducted at Fayoum University Hospital, Fayoum, Egypt, and Misr University Hospital. The patients were randomly divided into three groups, with each group comprising 60 patients. Group (A) included patients treated with Beta radiation following Pterygium excision, group (B) patients had primary pterygium excision with the application of 0.02% Mitomycin C for 5 minutes, and group (C) patients had conjunctival autograft to cover the bare area after pterygium excision. Patients were followed up for three years postoperatively.

Results:
group A had the highest recurrence rate (33.3%) followed by group B (13.3%), and finally group C presented a recurrence rate of 6.7%. Group B showed the highest rate of intra-ocular postoperative complications, while no intra-ocular complications were recorded in group C. Common complications in groups A and B were scleral melting, keratitis, and Dellen formation.

Conclusion:
Using conjunctival autograft after primary pterygium excision gives the best results regarding the rate of recurrence and postoperative complications. Meanwhile, B-radiation or Mitomycin C did not prove to be as good.
Sole Anti-inflammatory Immunomodulators: Innovative Drugs to Prevent and Treat Autoimmune Diseases and Proteopathies
Authors: Marciani Dante J. 
Published: January 2021

Objective:
To review the available sole anti-inflammatory immunomodulators or adjuvants,
different from pro-inflammatory ones, which elicit a Th2 immunity while inhibiting but
without abrogating Th1/Th17 immunities. Adjuvants that are useful to develop vaccines for T-cell
mediated autoimmune conditions.

Methods:
A literature search using PubMed and Google Scholar databases was made to identify
reports regarding adjuvants, mechanisms of action, pro-inflammatory autoimmunity and vaccines
to treat it, immunosuppressive agents, dendritic cells, helminths, immunotolerance, and infectious
diseases causing autoimmunity.

Results:
Some anti-inflammatory drugs to treat autoimmune diseases inhibit DNA or protein synthesis
causing global immunosuppression, which is reduced by using biologics to block key steps
in the inflammatory cascade. Fucosylated glycans from helminths, which are anti-inflammatory
but not immune-suppressive, offer an avenue to develop better drugs. Fucosylated glycans bind to
DC-SIGN, a receptor on dendritic cells, entering the cells via receptor-mediated endocytosis, biasing
their immunoresponse to a sole Th2 anti-inflammatory immunity, while inhibiting the proinflammatory
Th1/Th17 immunities. New anti-inflammatory drugs are particular plant-derived
fucosylated glycosides with immunological properties like those of helminth-derived glycans.
Another class of anti-inflammatory immunomodulators is ligands of the aromatic-hydrocarbon
receptor, which by activating this intracellular receptor, boosts the differentiation of regulatory Tcells,
inducing an anti-inflammatory immunity. However, aromatic ligands can also stimulate a
pro-inflammatory response. Exogenous aromatic ligands are usually delivered intracellularly using
carriers like nanoparticles, which upon translocation to the nucleus, activate this receptor.

Conclusions:
Autoimmune conditions and some infectious diseases, characterized by organ damage
due to pro-inflammatory autoimmune immunoresponses, could benefit from nonimmunosuppressive
agents to modulate immunity; this way, averting a damaging inflammation.
Short, but Highly Concentrated, Direct Inhalations of Essential Oil Molecules Improve Poor Sleep Quality: A Natural History Controlled, Withingroup, Self-administration Field Pilot Study
Authors: Schneider Rainer 
Published: January 2021

Background:Essential oils are among the preferred alternative remedies for treating sleep disturbance, but empirical evidence for their effectiveness is varied. According to a new line of research, an inhaler designed to deliver high concentrations of essential oil molecules directly into the nose effectively influences the hypothalamic-pituitaryadrenal axis and the autonomous nervous system.Objective:This study was run to investigate whether insomnia complaints were reduced upon use of the inhaler AromaStick® ‘Relax’.Methods:A documentation field study involving thirty individuals with a recorded history of non-specific insomnia complaints was conducted to determine the inhaler’s specific effects.Results:Upon the nightly use for one week, the odor inhaler strongly improved sleep quality and reduced symptoms associated with poor sleep. Depending on the dimensions tested, effect sizes ranged between 0.8 < d < 2.6. Strongest effects were found for ‘difficulty maintaining sleep’, ‘difficulty initiating sleep’ and ‘feeling recovered after sleeping’.Conclusion:The inhaler proved to be useful in mitigating sleep impairment. The effects were strongest in individuals reporting low sleep quality.
Ascorbic Acid in Health and Disease: A Review
Authors: Alur Ashwini , Das Paramita , Chikkamath Vinuth 
Published: January 2021

:
Ascorbic acid is an essential nutrient, and required for various metabolic activities in humans.
Typically citrus fruits, vegetables and organ meat are good source of vitamin C. It acts as
strong antioxidant and act as a scavenger in defence against free radical oxygen species. It has also
contributed to rejuvenate photo aged skin. It has ability to control the pigmentation of melanin by
inhibiting the enzyme tyrosinase by interacting with copper ions. It serves as a co-antioxidant with
vitamin E to regenerate alpha tocopherol, thereby retards cellular damage. Ascorbic acid is deprotonated
to form ascorbate anion, contributes to its prooxidant properties and act as a potential anticancer
agent. It reduces the mutation rate in mismatch-repair deficient human colon cancer cells.
Ascorbic acid is a phytochemical has micronutrients that act against the inflammation in arthritis.
Currently, challenges lies finding most stable formulation for achieving optimum results.
Performance of Resins Based on Poly(Divinylbenzene-co-Methyl Methacrylate) for Removal of Calcium and Magnesium Ions from Water
Authors: Bernardo Camilla N. , Silva Carla Michele F. , Aguiar Paula F. , Lucas Elizabete F. 
Published: January 2021

Background:
The mixing of the formation water present in oil and gas reservoirs and
the injected water (often seawater) can form inorganic incrustations, during enhanced oil recovery
operations. In this case, the cations (calcium, barium, strontium, iron, magnesium, etc.) of the injected
water react with the anions (mainly sulfate and carbonate) of the formation water and produce
inorganic salts that can precipitate in the reservoir rock, damaging the oil production by clogging
the pipes and production lines. One of the ways to prevent this problem is to remove the cations
from the injected water, but this is a challenging procedure.

Objective:
In this study, the Sulfonated polymer(divinylbenzene) (DVBS) and the copolymer sulfonated
poly(methyl methacrylate-co-divinylbenzene (MMA-DVB) were compared in their efficiencies
in reducing, to a very low level, the concentration of removing, chemically modified with sulfonic
(S) groups to ascertain their performance, the calcium and magnesium ions present in water.

Method:
The resins were modified with sulfonic groups and characterized. We used central composition planning with
batch tests to evaluate the adsorption, which occurred significantly for both ions using both resins with contact time of 10
minutes.

Results:
For both resins, calcium was preferentially adsorbed in relation to magnesium.

Conclusion:
Taking is account cost benefit, the copolymer MMA-DVBS (a less expensive adsorbent than the polymer
DVBS) presented a satisfactory behavior, making it a potential material for treatment of water.
Corpos, instituições e necropolítica: reflexões contemporâneas sobre a internação involuntária das pessoas com deficiência mental e as Comunidades Terapêuticas
Authors: Martins Laércio Melo 
Published: January 2021

RESUMO:O objetivo do presente artigo é analisar a execução da internação involuntária a partir da Lei n. 13.840/2019, que trata sobre o Sistema Nacional de Políticas Públicas sobre Drogas, ao considerar inclusive a Lei 10.216/01 (Lei da Reforma Psiquiátrica). Nesse caminho, foi considerada a construção social do indivíduo no processo de subjetivação atravessado pelas instituições médico-jurídicas ao pensar o cuidado médico em liberdade da pessoa com deficiência mental usuária de álcool ou outras drogas na Rede de Atenção Psicossocial brasileira. Além disso, buscou-se realizar uma compreensão sobre o controle sociopolítico do corpo, a partir do método hipotético-dedutivo, bem como descritivo, teórico e analítico, através das instituições. Como resultado da análise em documentos legislativos, livros e artigos acadêmicos, observa-se a opção necropolítica do Estado brasileiro, ao fortalecer às Comunidades Terapêuticas, em detrimento dos Centros de Atenção Psicossocial.
Editorial da seção especial "Pesquisadoras do Direito: nossas investigações, nossas produções acadêmicas”
Authors: Emerique Lilian Balmant , Achury Liliana Estupiñan , Storini Claudia 
Published: January 2021

RESUMO: Editorial da seção especial "Pesquisadoras do Direito: nossas investigações, nossas produções acadêmicas”ABSTRACT:Editorial (Introduction to the Special Issue "Pesquisadoras do Direito: nossas investigações, nossas produções acadêmicas")