bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of ABO and Rh Blood Group in Susceptibility, Severity, and Mortality of Coronavirus Disease 2019: A Hospital-Based Study From Delhi, India
Authors: Rana Rashmi , Ranjan Vivek , Kumar Naveen 
Published: November 2021

BackgroundABO and Rh blood group systems are associated with many diseases including cancerous, infectious, non-infectious, bacterial and viral diseases. Studies have shown association of blood groups A and O with higher and lower odds for coronavirus disease 2019 positivity, respectively.MethodsThis is a single-center, retrospective study conducted at Sir Ganga Ram Hospital, Delhi. We investigated the association of ABO and Rh blood groups with susceptibility to coronavirus disease 2019 infection, severity of disease, recovery period, and mortality of patients. Patients were enrolled from April 8, 2020 to October 4, 2020. A total of 2,586 real-time PCR (RT-PCR)-confirmed coronavirus disease 2019 (COVID-19) patients were recruited. Data was analyzed using chi-square test, odds ratio, and Mann–Whitney test to determine the association of blood groups.ResultsIn the 2,586 COVID-19-infected patients, the frequencies of A, B, O, and AB were 29.93%, 41.80%, 21.19%, and 7.98%, respectively. Of the patients, 98.07% were Rh positive. Blood group A (odds ratio, 1.53; CI, 1.40–1.66; p &lt; 0.001) and B (odds ratio, 1.15; CI, 1.06–1.24; p &lt; 0.001) is observed to be significantly associated with COVID-19 susceptibility, whereas blood group O (odds ratio, 0.65; CI, 0.59–0.71; p &lt; 0.001) and AB (odds ratio, 0.66; CI, 0.59–0.71; p &lt; 0.001) have low risk of COVID-19 infection.ConclusionA, B, and Rh+ are found to be more susceptible to COVID-19 infection, whereas blood groups O, AB, and Rh− are at a lower risk of COVID-19 infection. No association was found between blood groups and susceptibility to severity of disease and mortality.
Association Between Previous or Active Cancer and Clinical Outcomes in TAVR Patients: A Systematic Review and Meta-Analysis of 255,840 Patients
Authors: Diaz-Arocutipa Carlos , Torres-Valencia Javier , Zavaleta-Camacho Gabriela , Vicent Lourdes 
Published: November 2021

Background: It has been proposed that transcatheter aortic valve replacement (TAVR) may be an option for patients with cancer and severe aortic stenosis. We assessed the association between previous or active cancer and clinical outcomes in TAVR patients.Methods: We searched four electronic databases from inception to March 05, 2021. The primary outcome was all-cause mortality. Secondary outcomes were cardiovascular mortality, myocardial infarction, stroke, acute kidney injury, pacemaker implantation, major bleeding, and vascular complications. All meta-analyses were performed using a random-effects model. Relative risks (RRs) and adjusted hazard ratios (aHRs) with their 95% confidence interval (95% CI) were pooled.Results: Thirteen cohort studies involving 255,840 patients were included. The time period for mortality ranged from inpatient to 10 years. Patients with active cancer had a higher risk of all-cause mortality using both crude (RR, 1.46; 95% CI, 1.13–1.88) and adjusted (aHR, 1.79; 95% CI, 1.43–2.25) estimates compared to non-cancer group. In contrast, the risk of cardiovascular mortality (RR, 1.26; 95% CI, 0.58–2.73), myocardial infarction (RR, 0.94; 95% CI, 0.34–2.57), stroke (RR, 0.90; 95% CI, 0.75–1.09), pacemaker implantation (RR, 0.87; 95% CI, 0.50–1.53), acute kidney injury (RR, 0.88; 95% CI, 0.74–1.04), major bleeding (RR, 1.15; 95% CI, 0.80–1.66), and vascular complications (RR, 0.96; 95% CI, 0.79–1.18) was similar between patients with or without cancer.Conclusion: Our review shows that TAVR patients with active cancer had an increased risk of all-cause mortality. No significant association with secondary outcomes was found.
In-Depth Molecular Characterization of Neovascular Membranes Suggests a Role for Hyalocyte-to-Myofibroblast Transdifferentiation in Proliferative Diabetic Retinopathy
Authors: Boneva Stefaniya Konstantinova , Wolf Julian , Hajdú Rozina Ida , Prinz Gabriele , Salié Henrike , Schlecht Anja , Killmer Saskia , Laich Yannik , Faatz Henrik , Lommatzsch Albrecht , Busch Martin , Bucher Felicitas , Stahl Andreas , Böhringer Daniel , Bengsch Bertram , Schlunck Günther , Agostini Hansjürgen , Lange Clemens A. K. 
Published: November 2021

BackgroundRetinal neovascularization (RNV) membranes can lead to a tractional retinal detachment, the primary reason for severe vision loss in end-stage disease proliferative diabetic retinopathy (PDR). The aim of this study was to characterize the molecular, cellular and immunological features of RNV in order to unravel potential novel drug treatments for PDR.MethodsA total of 43 patients undergoing vitrectomy for PDR, macular pucker or macular hole (control patients) were included in this study. The surgically removed RNV and epiretinal membranes were analyzed by RNA sequencing, single-cell based Imaging Mass Cytometry and conventional immunohistochemistry. Immune cells of the vitreous body, also known as hyalocytes, were isolated from patients with PDR by flow cytometry, cultivated and characterized by immunohistochemistry. A bioinformatical drug repurposing approach was applied in order to identify novel potential drug options for end-stage diabetic retinopathy disease.ResultsThe in-depth transcriptional and single-cell protein analysis of diabetic RNV tissue samples revealed an accumulation of endothelial cells, macrophages and myofibroblasts as well as an abundance of secreted ECM proteins such as SPARC, FN1 and several types of collagen in RNV tissue. The immunohistochemical staining of cultivated vitreal hyalocytes from patients with PDR showed that hyalocytes express α-SMA (alpha-smooth muscle actin), a classic myofibroblast marker. According to our drug repurposing analysis, imatinib emerged as a potential immunomodulatory drug option for future treatment of PDR.ConclusionThis study delivers the first in-depth transcriptional and single-cell proteomic characterization of RNV tissue samples. Our data suggest an important role of hyalocyte-to-myofibroblast transdifferentiation in the pathogenesis of diabetic vitreoretinal disease and their modulation as a novel possible clinical approach.
Long-Term Outcomes and Prognosticators of Pediatric Primary Dilated Cardiomyopathy in an Asian Cohort
Authors: Wang Po-Yuan , Tseng Wei-Chieh , Fu Chun-Min , Wu Mei-Hwan , Wang Jou-Kou , Chen Yih-Sharng , Chou Nai-Kuan , Wang Shoei-Shen , Chiu Shuenn-Nan , Lin Ming-Tai , Lu Chun-Wei , Chen Chun-An 
Published: November 2021

Background: Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy. The epidemiological profiles and prognosticators of clinical outcomes in Asian populations are not well elucidated.Methods: Data of 104 children aged &lt;18 years with a diagnosis of primary DCM from January 1990 to December 2019 in our institutional database were retrospectively investigated. Relevant demographic, echocardiographic, and clinical variables were recorded for analysis. A P &lt;0.05 was considered statistically significant.Results: The median age at diagnosis was 1.4 years (interquartile range = 0.3–9.1 years), and 52.9% were males. During a median follow-up duration of 4.8 years, 48 patients (46.2%) were placed on the transplantation waitlist, and 52.1% of them eventually received heart transplants. An exceptionally high overall waitlist mortality rate was noted (27.1%), which was even higher (43.5%) if the diagnostic age was &lt;3 years. The 1-, 5-, and 10-year transplant-free were 61.1, 48.0, and 42.8%. Age at diagnosis &gt;3 years and severe mitral regurgitation at initial diagnosis were independent risk factors for death or transplantation (hazard ratios = 2.93 and 3.31, respectively; for both, P &lt;0.001). In total, 11 patients (10.6%) experienced ventricular function recovery after a median follow-up of 2.5 (interquartile range = 1.65–5) years. Younger age at diagnosis was associated a higher probability of ventricular function recovery.Conclusions: Despite donor shortage for heart transplantation and subsequently high waitlist mortality, our data from an Asian cohort indicated that transplant-free long-term survival was comparable with that noted in reports from Western populations. Although younger patients had exceptionally higher waitlist mortality, lower diagnostic age was associated with better long-term survival and higher likelihood of ventricular function recovery.
Parental Punishment and Adolescents’ Loneliness: A Moderated Mediation Model of General Self-Concept and Teacher–Student Relationships
Authors: Luo Yun , Wu Anyi , Zhang Hui 
Published: November 2021

Background: Loneliness adversely affects physical and mental health; therefore, it is necessary to explore its related influencing factors and mechanisms. This study investigated the mediating role of general self-concept in the association between parental punishment (PP) and adolescent loneliness and as well as the moderating role of teacher–student relationships (TSR) in Chinese students.Methods: Data were obtained from 1,169 Chinese students (10–18years old) using several self-report questionnaires: the Egna Minnen av Barndoms Uppfostran (EMBU), Self-Description Questionnaire (SDQ), Teacher–Student Relationships Scale (TSR), and UCLA Loneliness Scale. Data were analyzed with IBM SPSS 22.0, and the PROCESS macro program.Results: (1) Parental punishment had a positive predictive effect on adolescent loneliness, (2) parental punishment predicted adolescent loneliness not only directly but also indirectly through the mediating effect of general self-concept, and (3) teacher–student relationships moderated the influence of PP on adolescent loneliness.Conclusion: Adolescent loneliness is less affected by parental punishment when TSRs are better. Additionally, when adolescents are punished less by their parents and have good teacher–student relationships, they have higher general self-concepts.Limitations: This study’s cross-sectional research design was unable to show causal relationships among the factors influencing adolescent loneliness.
Prevalence of Dementia in China in 2015: A Nationwide Community-Based Study
Authors: Qi Shige , Yin Peng , Zhang Han , Zhang Qingjun , Xiao Yize , Deng Ying , Dong Zhong , Shi Yan , Meng Jun , Peng Dantao , Wang Zhihui 
Published: November 2021

Objective: This study aims to estimate the prevalence of dementia and Alzheimer's disease (AD) and associated risk factors among the general Chinese population.Methods: We carried out a nationwide study including 24,117 participants aged 60 years and older in China using a multistage clustered sampling. Dementia and AD were diagnosed according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders and the criteria issued by the National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association. Face-to-face interviews were administered by the trained interviewers to obtain information on demographics, lifestyle factors, and previous diseases.Results: The overall weighted prevalence of dementia was 4.22% (95%CI 2.27–6.17%) for people aged 60 years and older, was higher in women than in men and increased with age. Daily tea drinking and daily exercises were the protective factors for both dementia and AD. Engaging in social and intellectual activities was significantly associated with a lower risk of dementia and AD.Conclusions: A large number of population with dementia posed a significant challenge to China where the population is rapidly aging. The increase of public awareness, building more care facilities, and training dementia specialists and professional caregivers are all urgently needed and should be the future priorities of dementia care in China.
Addressing Patients’ Alcohol Consumption–A Population-Based Survey of Patient Experiences
Authors: Lid Torgeir Gilje , Karlsson Nadine , Thomas Kristin , Skagerström Janna , O'Donnell Amy , Abidi Latifa , Nilsen Per 
Published: November 2021

Objectives: To identify the proportion of the population that had experienced that alcohol was addressed in health care the previous year, to explore experiences and perceived effects of addressing alcohol, and to investigate the proportion of risky drinkers in the population.Methods: Cross-sectional national web-based survey with 1,208 participants. Socio-demographic data, alcohol consumption (AUDIT-C), and experiences with alcohol conversations were investigated.Results: Approximately four in five respondents had visited health care the past 12 months, and one in six reported having experienced addressing alcohol. Women and older respondents were less likely to report having experienced alcohol conversations compared to other groups. Risky drinkers were not more likely to have experienced an alcohol conversation, but reported longer duration of alcohol conversations and more frequently perceived addressing alcohol as awkward or judgmental. Almost a third of respondents were classified as risky drinkers.Conclusion: The proportion experiencing addressing alcohol in routine health care is low, also among risky drinkers, and risky drinkers more frequently experienced the conversations as judgmental. More sensitive and relevant ways of addressing alcohol in health care is needed.
Development of a Clamping Device for Tensile Testing of Intracranial Flow Diverter Stents
Authors: Bukor Csongor , Károly Dóra , Csippa Benjamin 
Published: November 2021

Abstract
The main danger of a brain aneurysm (a sack-like bulge on the vessel wall) is that in the event of a rupture a severe hemorrhage can occur which may cause death. However, if doctors have tools at their disposal, such as numerical models and simulations for analyzing patient-specific blood vessels, they could use them to decide if a particular treatment is necessary and if so, when. For such models, the different mechanical characteristics of the flow control devices are the input data. Several of these mechanical properties of the devices, such as modulus of elasticity and tensile strength, are determined by tensile testing. In the course of our research, we have developed a clamping device suitable for uniaxial tensile testing of flow diverter stents.
Development of Pneumatic Deformability Test of Polylactic Acid Films
Authors: Gere Dániel , Pölöskei Kornél 
Published: November 2021

Abstract
The aim of the present study is to develop a test method suitable for modelling thermoforming processes and which provides an index that accurately characterises the thermoformability of a film or sheet at a given temperature and pressure. For this purpose, the elevated temperature pneumatic deformability test was considered to be the most suitable. During the test, the film is blown until it tears, which takes only a few seconds. We recorded blowing during the test, and used the images to determine the ascent (k) of the specimens and approach the estimated surface of the deformed specimens with a sphere.
Implementasi Metode Role Playing Pada Pembelajaran Tematik di Madrasah Ibtidaiyah Darul Ulum Sukorambi Jember Tahun Pelajaran 2018/2019
Authors: Ilmanuddin Ilmanuddin , Siregar Robby Sadha 
Published: November 2021

Kegiatan belajar mengajar siswa disekolah yang berpusat pada guru mengakibatkan siswa hanya menerima mata pelajaran secara pasif pembelajaran yang seperti ini mengakibatkan siswa kurang berminat dalam mengikuti pembelajaran tematik,proses pembelajaran yaitukurang maksimal pelaksanaan proses pembelajaran yang diterapkan sehingga peserta didik kurang menarik dengan pembelajaran dan metode yang sebelumnya, Sehingga berpengaruh kepada pemahaman siswa. Berdasarkan latar belakang Fokus dalam penelitian ini adalah 1)Bagaimana Perencanaan metode Rol Playing pada pembelajaran tematik di Madrasah IbidaiyahDarul Ulum Sukorambi Jember tahun pelajaran 2018/2019? 2)Bagaimana Pelaksanaanmetode Rol Playing pada pembelajaran tematik di Madrasah Ibidaiyah Darul Ulum Sukorambi Jember tahun pelajaran 2018/2019? 3) Bagaimna evalusai Metode Role Playingpada pembelajaran tematik di Madrasah Ibidaiyah Darul Ulum Sukorambi Jember tahun pelajaran 2018/2019? Hasil dari penelitian ini adalah: Perencanaan metode Role Playing pada pembelajaran tematik di kelas IV yaitu: dengan menyusun Program tahunan, program semester, silabus dan RPP(Rencana Pelaksanaan Pembelajaran) dan dikembangkan dalam RPP dengan menggunakan metode Role Playing sehingga setiap siswa dapat memahami materi yang telah dipelajarinya.
Implementasi Strategi Cooperative Learning Tipe Jigsaw dalam Pembelajaran Akidah Akhlak Kelas V MIN Bangka Belitung Pontianak
Authors: Firmansyah Firmansyah , Zaini Akhmad 
Published: November 2021

Penelitian ini dilatar belakangi oleh adanya permasalahan yang terjadi pada MIN Bangka Belitung Pontianak seperti guru kurang melibatkan siswa dalam materi pembelajaran, guru cenderung menyampaikan materi dengan menggunakan metode ceramah tanpa adanya variasi sehingga menyebabkan kejenuhan dalam belajar, guru kurang memahami dalam tentang memilih dan menentukan strategi cooperative learning tife jigsawyang tepat sehingga berdampak pada terciptanya proses pembelajara yang lebih baik. Penelitian bertujuan untukmengetahui: perencanaan, langkah-langkah, dan evaluasi dalam pembelajaran Materi Aqidah dengan Strategi Cooperative Tipe Jigsaw dalam pembelajaran Akidah Akhlak Materi Sikap pada guru di Kelas V MIN Bangka Belitung Pontianak Tahun Pelajaran 2017/2018. Hasil penelitian ini dapat disimpulkan bahwa Perencanaan Strategi Cooperative Learning Tipe Jigsawdalam Pembelajaran Akidah Akhlak Pada Materi Akhlak Tercela di Kelas V MIN Bangka Belitung Pontianak dengan lebih baik dan siswa lebih aktif dalam proses pembelajaran; langkah-langkah strategi cooperative learning tipe jigsaw dalam materi sikap siswa di sekolahdi kelas V MIN dibagi menjadi 5 kelompok, setiap kelompok diksih materi pembelajaran, dan siswa mendiskusikan dengan materi tersebut; Pelaksanaan evaluasi proses dan hasil kegiatan pembelajaran yang menggunakan langkah strategi cooperative learning tipe jigsaw dalam materi sikap siswa di sekolahdi kelas V MIN Negeri Bangka Belitung Pontianak adalah menggunakan tes tertulis dan tes lisan juga mengunakan penilain proses dari observasi siswa saat proses pembelajaran atau setelah mata kuliah selesai.
Peningkatan Hasil Belajar PKn Melalui Model Word Square Kelas 3 MIS NU 2 Pontianak
Authors: Fathurrosi Fathurrosi , Rohmah Nikmatur 
Published: November 2021

PKN Subject is on one of lesson implemented on SD, SMP and SMA to apply student characters and to form the student to understand and love home land also understand global life. The research background of the low student achievement on study still using lecture method, giving assignments, answer and guestion on PKN subject. The purposes of this research: 1.how student achievement on PKN subject before using word sguare model. 2. How student achievement on PKN subject after using calassroom action rescarch with quantitative approach. The sample is the students of class III MIS NU 2 Pontianak.in order to get the data, researcher using observation shett, measurement technique and documentation study.The result concluded: 1.the student achievement before using word square model the average is 53 ( good category ) with KKM > 70 as 5 or 25% and students with KKM < 70 as 15 students or 75%. 2. The student achievement after using word square on cycle 1 is 68,5 ( Better category) with KKM 55%. On the other hands, cycle 11 is 82,5 (Great category ) with KKM 90%.

Mata pelajaran PKn salah satu pelajaran yang diterapkan mulai dari SD, SMP dan SMA dengan membekali karakter dan membentuk peserta didik cinta tanah air dan paham dalam kehidupan yang serba global. Rumusan penelitian ini; 1) Bagaimanan hasil belajar siswa pada mata pelajaran pendidikan kewarganegaraan sebelum menggunakan model pembelajaran word square kelas 3 MIS NU 2 Pontianak. 2) Bagaimana hasil belajar siswa pada mata pelajaran pendidikan kewarganegaraan setelah menggunakan model pembelajaran word square kelas 3 MIS NU 2 Pontianak. Metode dan jenis penelitian ini menggunakan jenis penelitian tindakan kelas dengan pendekatan kuantitatif.Subjek penelitian ini adalah siswa kelas III MIS NU 2 Pontianak. Untuk mendapatkan data peneliti menggunakan lembar observasi, teknik pengukuran dan studi dokumentasi. Hasil dari penelitian ini yaitu: 1) Hasil belajar siswa pada Mata Pelajaran PKn sebelum menggunakan model pembelajaran Word Square diperoleh nilai rata-rata sebesar 53 (kategori cukup) dengan siswa yang tuntas mencapai nilai KKM ? 70 sebanyak 5 atau 25% dan siswa yang tidak tuntas dengan nilai KKM ? 70 sebanyak 15 siswa atau 75%. 2) Hasil belajar siswa pada Mata Pelajaran PKn setelah menggunakan model pembelajaran Word Square pada siklus I sebesar 68,5 (kategori baik) dan siswa yang mencapai KKM sebesar 55%. Sedangkan pada siklus II sebesar 82,5 (kategori sangat baik) dan siswa yang mencapai KKM sebesar 90.
PAPÉIS SOCIAIS E DESIGUALDADE DE GÊNERO NO ESPAÇO ESCOLAR
Authors: Sombra Ana Quesado , Leonardo Geórgia de Mendonça Nunes 
Published: November 2021

Historicamente, as relações de gênero são atravessadas por paradigmas sobre os papéis sociais atribuídos aos homens e às mulheres, que reverberam em preconceitos, discriminações e desigualdades, bem como em expressões de violência contra a mulher, nos diversos contextos sociais. Essas concepções presentes na sociedade são também percebidas no espaço escolar, nos discursos, práticas pedagógicas e conteúdos didáticos que naturalizam a hierarquia nas relações entre homens e mulheres, e legitimam a desigualdade de gênero. Trata-se de uma revisão bibliográfica, realizada por meio de buscas nas bases de dados SciELO e Periódicos CAPES. Foram selecionados artigos publicados de janeiro de 2010 a agosto de 2020, objetivando investigar como a escola tem dialogado sobre os papéis sociais de gênero, baseados no modelo de masculinidade hegemônica, e como tais estereótipos contribuem para a reprodução e naturalização da desigualdade de gênero nas relações sociais entre homens e mulheres no espaço escolar. Para vislumbrarmos mudança no atual cenário, é essencial reconhecer a escola como lócus de transformação social, que se dá por meio de reflexão e consciência crítica. Cabe à escola utilizar estratégias que visem a problematizar as questões de gênero e ressignificar os paradigmas sociais que geram a desigualdade de gênero. Ademais, salientamos a importância da participação do poder público na promoção de formação docente sobre a temática gênero e diversidade, e proposição de políticas públicas que favoreçam a participação efetiva das mulheres, a fim de garantir uma educação para a equidade de gênero, com vistas ao desenvolvimento de uma sociedade mais justa e digna.