bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental post-traumatic stress and psychiatric care utilisation among refugee adolescents
Authors: Berg Lisa , de Montgomery Edith , Brendler-Lindquist Monica , Mittendorfer-Rutz Ellenor , Hjern Anders 
Published: June 2021

AbstractParental psychiatric morbidity related to experiences of war and trauma has been associated with adverse psychological outcomes for children. The aim of this study was to investigate parental post-traumatic stress in relation to psychiatric care utilization among children of refugees with particular attention on the child’s own refugee status, sex of both child and parents, and specific psychiatric diagnoses. This was a register study in a population of 16 143 adolescents from refugee families in Stockholm County born 1995–2000 and followed between 2011 and 2017 (11–18 years old). Parental post-traumatic stress, identified in three levels of care, was analysed in relation to child and adolescent psychiatric care use. Cox regression analysis was used to estimate hazard ratios (HR) and 95% confidence intervals (CI), adjusted for duration of residence and demographic and socioeconomic variables. Having a mother with post-traumatic stress was associated with higher psychiatric care utilization, with adjusted HR 2.44 (95% CI 1.90–3.14) among foreign-born refugee children and HR 1.77 (1.33–2.36) among Swedish-born children with refugee parents, with particularly high risks for children with less than five years of residence (HR 4.03; 2.29–7.10) and for diagnoses of anxiety and depression (HR 2.71; 2.11–3.48). Having a father with post-traumatic stress was not associated with increased HRs of psychiatric care utilization. Similar results were seen for boys and girls. Treatment for post-traumatic stress should be made available in refugee reception programmes. These programmes should use a family approach that targets both parents and children.
Second-line treatments for Advanced Hepatocellular Carcinoma: A Systematic Review and Bayesian Network Meta-analysis
Authors: Solimando Antonio Giovanni , Susca Nicola , Argentiero Antonella , Brunetti Oronzo , Leone Patrizia , De Re Valli , Fasano Rossella , Krebs Markus , Petracci Elisabetta , Azzali Irene , Nanni Oriana , Silvestris Nicola , Vacca Angelo , Racanelli Vito 
Published: June 2021

Abstract
Background & Aims
A plethora of second-line therapies have been recently introduced for hepatocellular carcinoma (HCC) treatment with promising results. A meta-analysis of second-line treatments for HCC has been performed to better tailor their use based on improved patient stratification and to identify the best available option.

Methods
Pubmed, Scopus, Web of Science, and ClinicalTrials.gov were searched for randomized controlled trials evaluating second-line treatment for advanced HCC in patients already treated with sorafenib. The primary outcome was overall survival (OS). Secondary outcomes were progression-free survival (PFS) and drug withdrawal due to adverse events. Network meta-analyses were performed considering placebo as the basis for comparison in efficacy and safety analyses. Subgroup stratification considered gender, age, sorafenib-responsiveness and drug tolerability, viral infection, macrovascular invasion, HCC extrahepatic spread, performance status, and alpha-fetoprotein levels.

Results
Fourteen phase II or III randomized controlled trials, involving 5,488 patients and 12 regimens, were included in the analysis. Regorafenib (hazard ratio (HR) = 0.63, 95% confidence interval (CI) = 0.50–0.79), cabozantinib (HR = 0.76, 95% CI = 0.63–0.92), and ramucirumab (HR = 0.82, 95% CI = 0.70–0.76) significantly prolonged OS compared with placebo. Cabozantinib (HR = 0.44, 95% CI = 0.36–0.52), regorafenib (HR = 0.46, 95% CI = 0.37–0.56), ramucirumab (HR = 0.54, 95% CI = 0.43–0.68), brivanib (HR = 0.56, 95% CI = 0.42–0.76), S-1 (HR = 0.60, 95% CI = 0.46–0.77), axitinib (HR = 0.62, 95% CI = 0.44–0.87), and pembrolizumab (HR = 0.72, 95% CI = 0.57–0.90) significantly improved PFS compared with placebo. None of the compared drugs deemed undoubtedly superior after having performed a patients’ stratification.

Conclusions
The results of this network meta-analysis suggest the use of regorafenib and cabozantinib as second-line treatments in HCC.
Can global rainfall estimates (satellite and reanalysis) aid landslide hindcasting?
Authors: Ozturk U. , Saito H. , Matsushi Y. , Crisologo I. , Schwanghart W. 
Published: June 2021

AbstractPredicting rainfall-induced landslides hinges on the quality of the rainfall product. Satellite rainfall estimates or rainfall reanalyses aid in studying landslide occurrences especially in ungauged areas, or in the absence of ground-based rainfall radars. Quality of these rainfall estimates is critical; hence, they are commonly crosschecked with their ground-based counterparts. Beyond their temporal precision compared to ground-based observations, we investigate whether these rainfall estimates are adequate for hindcasting landslides, which particularly requires accurate representation of spatial variability of rainfall. We developed a logistic regression model to hindcast rainfall-induced landslides in two sites in Japan. The model contains only a few topographic and geologic predictors to leave room for different rainfall products to improve the model as additional predictors. By changing the input rainfall product, we compared GPM IMERG and ERA5 rainfall estimates with ground radar–based rainfall data. Our findings emphasize that there is a lot of room for improvement of spatiotemporal prediction of landslides, as shown by a strong performance increase of the models with the benchmark radar data attaining 95% diagnostic performance accuracy. Yet, this improvement is not met by global rainfall products which still face challenges in reliably capturing spatiotemporal patterns of precipitation events.
Using MALDI-TOF mass spectrometry to identify ticks collected on domestic and wild animals from the Democratic Republic of the Congo
Authors: Ngoy Steve , Diarra Adama Zan , Laudisoit Anne , Gembu Guy-Crispin , Verheyen Erik , Mubenga Onésime , Mbalitini Sylvestre Gambalemoke , Baelo Pascal , Laroche Maureen , Parola Philippe 
Published: June 2021

AbstractMatrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) has recently emerged as an alternative to morphological and molecular tools to identify tick species. In this study, we set out to evaluate and confirm the ability of MALDI-TOF MS to identify different species of ticks collected in the Democratic Republic of the Congo and preserved in 70% ethanol. A total of 575 ticks, of which 530 were collected from domestic pigs and 45 from wild animals, were subjected to MALDI-TOF MS analysis to evaluate the intraspecies reproducibility and interspecies specificity of MS profiles obtained from the different species. Morphologically, the ticks belonged to seven different species, namelyRhipicephalus complanatus,Rhipicephalus congolensis,Haemaphysalis muhsamae,Ixodes cumulatimpunctatus,Amblyomma exornatum,Amblyomma compressumand an unidentifiedRhipicephalussp. A total of 535/575 (93%) of the spectra obtained were of good enough quality to be used for our analyses. Our home-made MALDI-TOF MS arthropod database was upgraded with spectra obtained from between one and five randomly selected specimens per species. For these reference specimens, molecular identification of the ticks was also made using 16S, 12S rDNA genes and the Cox1 mtDNA gene sequencing. The remaining good quality spectra were then queried against the upgraded MALDI-TOF MS database, showing that 100% were in agreement with the morphological identification, with logarithmic score values (LSVs) between 1.813 and 2.51. The consistency between our morphological, molecular and MALDI-TOF MS identification confirms the capability and precision of MALDI-TOF MS for tick identification.
Toward a comparative anthropology of activism: activist identity formations in Germany and Uganda
Authors: Podgornik-Jakil Žiga , Bens Jonas 
Published: June 2021

AbstractThere is an ongoing debate in anthropology on the kinds of subject positions activists ascribe to the marginalized actors they encounter and the political consequences this brings about. Drawing from ethnographic research on refugee activism in Germany and transitional justice activism in Uganda, we revisit the respective debates on humanitarian activism, human rights activism, and political activism and argue to reframe the analysis. Instead of looking for the “right” subject position activists should ascribe to the people they engage with, the anthropology of activism should embrace a research approach that looks at the material conditions, in which activists and their subjects find themselves in and the kind of agency they are able to develop within these conditions.
Promoting Active Citizenship in Mathematics and Science Teaching
Authors: Maass Katja , Sorge Stefan , Romero-Ariza Marta , Hesse Alice , Straser Oliver 
Published: June 2021

AbstractThe world is facing severe global challenges such as climate change, food security, rising migration, social justice, or the current corona crisis. In these times, citizenship education seems more important than ever. How can this citizenship education relate to mathematics and science learning? The research project MaSDiV (Supporting mathematics and science teachers in addressing diversity and promoting fundamental values) connected mathematics and science with citizenship education by modeling real-life problems relevant to society. In this paper, we present the foundational design features of the PD course as well the results from the accompanying evaluation of this PD course, which was implemented by partners in six countries to support teachers in connecting mathematics and science education with citizenship education. More specifically, we investigate how participating teachers experienced the PD program; how their self-efficacy beliefs, learning-related beliefs, as well as teaching practices change; and which factors contributed to that change. In order to investigate the outcome of the PD program, we surveyed N = 311 mathematics and science teachers’ pre- and post-participation of the PD in six different European countries. Among others, our results show that in general, most participating teachers reported a high overall satisfaction with the course across all six participating countries. They also indicate that teachers’ self-efficacy beliefs about using relevant contexts, their learning-related beliefs about the benefits of using contexts, as well as their own teaching practice changed significantly after participating in the MaSDiV PD course.
Associations between Adolescents’ Social Leisure Activities and the Onset of Mental Disorders in Young Adulthood
Authors: Timonen Johanna , Niemelä Mika , Hakko Helinä , Alakokkare Anni , Räsänen Sami 
Published: June 2021

AbstractThe association of leisure time activities with specific mental disorders has mainly remained unclear because of lack of such research. This study analyzed the association of different levels of social leisure time activity during adolescence (ages 15–16 years) with the incidence of mental disorders during adolescence and young adulthood between the ages of 16–33 years. The study population consisted of 6838 (females 51.5%) participants from the longitudinal follow-up study, the Northern Finland Birth Cohort 1986, covering 72% of the total 1986 birth cohort. Psychiatric morbidity of the participants was followed through nationwide health registers until the end of the year 2018 when the participants were 33 years old. High social leisure time activity in adolescence associated with lower incidence of psychiatric disorders in general, and specifically, with affective, anxiety, and substance use disorders. Low social leisure time activity was related to increased incidence of any psychiatric disorder in general, and particularly to anxiety and behavioral disorders. In terms of prevention of mental disorders, these study findings encourage families, schools and other communities to continue to enhance and develop community-based social leisure time activities for children and adolescents.
Causal Sufficiency and Actual Causation
Authors: Beckers Sander 
Published: June 2021

AbstractPearl opened the door to formally definingactual causationusing causal models. His approach rests on two strategies: first, capturing the widespread intuition thatX=xcausesY=yiffX=xis aNecessary Element of a Sufficient SetforY=y, and second, showing that his definition gives intuitive answers on a wide set of problem cases. This inspired dozens of variations of his definition of actual causation, the most prominent of which are due to Halpern & Pearl. Yet all of them ignore Pearl’s first strategy, and the second strategy taken by itself is unable to deliver a consensus. This paper offers a way out by going back to the first strategy: it offers six formal definitions ofcausal sufficiencyand two interpretations of necessity. Combining the two gives twelve new definitions of actual causation. Several interesting results about these definitions and their relation to the various Halpern & Pearl definitions are presented. Afterwards the second strategy is evaluated as well. In order to maximize neutrality, the paper relies mostly on the examples and intuitions of Halpern & Pearl. One definition comes out as being superior to all others, and is therefore suggested as a new definition of actual causation.
Ethical issues in biomedical research using electronic health records: a systematic review
Authors: Piasecki Jan , Walkiewicz-Żarek Ewa , Figas-Skrzypulec Justyna , Kordecka Anna , Dranseika Vilius 
Published: June 2021

AbstractDigitization of a health record changes its accessibility. An electronic health record (EHR) can be accessed by multiple authorized users. Health information from EHRs contributes to learning healthcare systems’ development. The objective of this systematic review is to answer a question: What are ethical issues concerning research using EHRs in the literature? We searched Medline Ovid, Embase and Scopus for publications concerning ethical issues of research use of EHRs. We employed the constant comparative method to retrieve common ethical themes. We descriptively summarized empirical studies. The study reveals the breadth, depth, and complexity of ethical problems associated with research use of EHRs. The central ethical question that emerges from the review is how to manage access to EHRs. Managing accessibility consists of interconnected and overlapping issues: streamlining research access to EHRs, minimizing risk, engaging and educating patients, as well as ensuring trustworthy governance of EHR data. Most of the ethical problems concerning EHR-based research arise from rapid cultural change. The framing of concepts of privacy, as well as individual and public dimensions of beneficence, are changing. We are currently living in the middle of this transition period. Human emotions and mental habits, as well as laws, are lagging behind technological developments. In the medical tradition, individual patient’s health has always been in the center. Transformation of healthcare care, its digitalization, seems to have some impacts on our perspective of health care ethics, research ethics and public health ethics.
The case for biotechnological exceptionalism
Authors: Heinrichs Jan-Hendrik 
Published: June 2021

AbstractDobiomedicalinterventions raise special moral concerns? A rising number of prominent authors claim that at least in the case of biomedical enhancement they do not. Treating biomedical enhancements different from non-biomedical ones, they claim, amounts to unjustified biomedical exceptionalism. This article vindicates the familiar thesis that biomedical enhancement raises specific concerns. Taking a close look at the argumentative strategy against biomedical exceptionalism and provides counterexamples showing that the biomedical mode of interventions raises concerns not relevant otherwise. In particular, biomedical interventions throughout raise concerns of informed consent, which only rarely turn up in comparable non-biomedical interventions.
Detection and localization of partial audio matches in various application scenarios
Authors: Maksimović Milica , Aichroth Patrick , Cuccovillo Luca 
Published: June 2021

AbstractIn this paper, we describe various application scenarios for archive management, broadcast/stream analysis, media search and media forensics which require the detection and accurate localization of unknown partial audio matches within items and datasets. We explain why they cannot be addressed with state-of-the-art matching approaches based on fingerprinting, and propose a new partial matching algorithm which can satisfy the relevant requirements. We propose two distinct requirement sets and hence two variants / settings for our proposed approach: One focusing on lower time granularity and hence lower computational complexity, to be able to deal with large datasets, and one focusing on fine-grain analysis for small datasets and individual items. Both variants are tested using distinct evaluation sets and methodologies and compared with a popular audio matching algorithm, thereby demonstrating that the proposed algorithm achieves convincing performance for the relevant application scenarios beyond the current state-of-the-art.
Exploring patients’ pharmacy stories: an analysis of online feedback
Authors: Loo Jared , Greaves Georgina , Lewis Penny J. 
Published: June 2021

AbstractBackgroundStudies have demonstrated the potential for patient feedback to inform quality care as well as a direct relationship between patient experience and clinical outcomes. Over recent years, there has been increasing use of online patient feedback platforms, however, there has been little study of the content of patient feedback relating to pharmacy and pharmacy services.ObjectiveThis study explores the content of online feedback provided by patients from across the UK in relation to their experiences of their interaction with pharmacy staff and pharmacy services.Main outcome measureContent of online patient feedback relating to pharmacy.MethodPatient stories published on Care Opinion, a national online patient feedback platform, for a one-year period were searched for all content relating to patients’ pharmacy experiences. A thematic and sentiment analysis was conducted on 237 patient stories.ResultsPatient stories related to supply, staff attitudes, services, accessibility, systems, and errors. Patient sentiment depended on pharmacy setting, but staff attitudes, services, and accessibility were generally positive across all settings. Waiting time was the most common complaint in both hospital and community pharmacies with stories relaying experiences of slow discharge, stock shortages and poor communication and collaboration between pharmacies and GP surgeries.ConclusionsOnline patient feedback highlighted factors important to patients when interacting with pharmacies and their staff. Medication supply was the primary topic of patient stories with waiting times and stock shortages being clear areas for improvement; however, accessibility, pharmacy services and advice were key strengths of the profession. Further research is needed to understand how online patient feedback can be used effectively to inform improvements in pharmacy services.
Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review
Authors: Amdal Cecilie Delphin , Pe Madeline , Falk Ragnhild Sørum , Piccinin Claire , Bottomley Andrew , Arraras Juan Ignacio , Darlington Anne Sophie , Hofsø Kristin , Holzner Bernard , Jørgensen Nina Marie Høyning , Kulis Dagmara , Rimehaug Stein Arne , Singer Susanne , Taylor Katherine , Wheelwright Sally , Bjordal Kristin 
Published: June 2021

Abstract
Purpose
This systematic review was performed to identify all relevant health-related quality of life (HRQoL) issues associated with COVID-19.

Methods
A systematic literature search was undertaken in April 2020. In four teams of three reviewers each, all abstracts were independently reviewed for inclusion by two reviewers. Using a pre-defined checklist of 93 criteria for each publication, data extraction was performed independently by two reviewers and subsequently compared and discussed. If necessary, a third reviewer resolved any discrepancies. The search was updated in February 2021 to retrieve new publications on HRQoL issues including issues related to the long-term consequences of COVID-19.

Results
The search in April 2020 identified 3342 potentially relevant publications, and 339 publications were selected for full-text review and data extraction. We identified 75 distinct symptoms and other HRQoL issues categorized into 12 thematic areas; from general symptoms such as fever, myalgia, and fatigue, to neurological and psychological issues. The updated search revealed three extra issues experienced during active disease and long-term problems with fatigue, psychological issues and impaired cognitive function.

Conclusion
This first comprehensive systematic review provides a detailed overview of the wide range of HRQoL issues experienced by patients with COVID-19 throughout the course of the disease. It demonstrates the devastating impact of the disease and provides critically important information for clinicians, to enable them to better recognize the disease and to provide knowledge important for treatment and follow-up. The results provided the foundation for the international development of a COVID-19 specific patient-reported HRQoL questionnaire.
Many candidates for a single chair: a critical review of the genetic determinant of flat fruit shape trait in peach (Prunus persica L. Batsch)
Authors: Cirilli Marco , Rossini Laura 
Published: June 2021

AbstractKnown since ancient times, flat-shaped peach (Prunus persica L. Batsch) fruits have aroused considerable research interest. Breeding activities for this trait have expanded since the 1980s of the last century in several countries, in parallel with research into its genetic basis. Following the need for molecular markers to assist selection, linkage mapping studies have positioned the flat shape S locus at the end of chromosome 6. Recently, a series of independent studies focused on detailed characterization of the genomic region harbouring the S locus and different hypotheses about the candidate gene or variant were proposed: from a constitutively activated cell death 1 protein (PpCAD1) to a Brassinosteroid insensitive 1-associated receptor kinase 1 group (PpLRR-RLK) until the discovery of large structural variant (a chromosomal inversion of about 1.7 Mb) putatively affecting an OVATE Family Protein (PpOFP1) and a homolog of sucrose non-fermenting 1-related kinase (PpSNF4), respectively, located at the proximal and distal breakpoints. This short review revises historical studies and recent literature, integrating reanalysis of available genetic and genomic data, to provide a critical overview of the topic and highlight avenues for further research.
A Review of Elinor Mason’s Ways to be Blameworthy
Authors: Carlsson Andreas Brekke 
Published: June 2021

AbstractIn this review, I summarize Elinor Mason’s Ways to be Blameworthy and raise some worries concerning three aspects of her book: her account of the knowledge condition on moral responsibility, her notion of blame and its justification as well as Mason’s conception of extended blameworthiness.