bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Benzodiazepines and Z-Drugs in Nursing Home Residents with Dementia: Prevalence and Appropriateness
Authors: Rijksen Dirk O.C. , Zuidema Sytse U. , de Haas Esther C. 
Published: December 2021

Background: Guidelines worldwide recommend restricted prescription of benzodiazepine receptor agonists (BZRAs), i.e., benzodiazepines and Z-drugs, for the treatment of dementia-associated behavioral and psychological symptoms and insomnia. Objective: To assess the prevalence and appropriateness of BZRA use among nursing home residents with dementia. Methods: This is a post-hoc analysis of BZRA prescriptions from two intervention studies on psychotropic drug use, conducted from 2016 to 2018. It includes 1,111 residents of dementia special care units from 24 Dutch long-term care organizations. We assessed the prevalence of use of continuous and as-needed BZRA prescriptions and their association with registered symptoms. Continuous BZRA prescriptions were evaluated for appropriateness, i.e., whether indication, dosage, duration, and evaluation accorded with guidelines for the treatment of challenging behavior in dementia and sleep disorders. Results: The prevalence of BZRA use is 39.2% (95% CI: 36.3%–42.0%): continuous 22.9%; only as-needed 16.3%. Combinations of preferred BZRAs and appropriate indications occur in 19.0% of continuous anxiolytic prescriptions and 44.8% of hypnotic prescriptions. Frequently registered inappropriate indications are aggression/agitation for anxiolytics (continuous: 75.7%; as-needed: 75.2%) and nighttime agitation for hypnotics (continuous: 40.3%; as-needed: 26.7%). None of the continuous prescriptions with appropriate indications were appropriate for all other items. For most of the prescriptions, duration and time to evaluation exceeded 4 weeks. Conclusion: BZRA use in nursing home residents with dementia is highly frequent. A large proportion of prescriptions do not follow the guidelines with regard to indication, exceed the recommended duration and are not evaluated in a timely manner. The discrepancy between evidence-based guidelines and daily practice calls for an exploration of factors maintaining inappropriate use.
EDUKASI MANFAAT JUS KURMA (DACTILIFERA PHOENIX) BAGI IBU HAMIL ATERM
Authors: Mutiah Cut , Veri Nora 
Published: December 2021

Pembatasan asupan makanan dan minuman selama persalinan dapat menyebabkan terjadinya hipoglikemia dan dehidrasi pada ibu bersalin yang dapat berpengaruh pada kontraksi/ his sehingga dapat menghambat kemajuan persalinan. Metode dalam kegiatan pengabdian masyarakat yang dilaksanakan dengan metode pendidikan kesehatan. Hasil pengabdian masyarakat didapatkan hasil pengetahuan ibu hamil tentang manfaat jus kurma dalam proses kelahiran masih sangat rendah dengan nilai rerata 40,5 (41%), Mayoritas ibu hamil tidak mengetahui manfaat kurma selama proses persalinan. Setelah dilakukan edukasi peningkatan nilai rata-rata pengetahuan ibu menjadi 93,5 (91%). Hasil diskusi menyatakan bahwa masih ada pembatasan asupan makanan dan cairan menjelang persalinan. Mitos yang beredar bahwa saat persalinan, ibu sudah tidak boleh lagi mengkonsumsi makanan dan hanya diperbolehkan minum air teh atau susu selama proses persalinan berlangsung. Sebab, jika ibu banyak mengkonsumsi makanan saat persalinan, maka akan menyebabkan banyaknya jumlah feses yang keluar bersamaan pada saat bersalin. Terdapat peningkatan pengetahuan ibu hamil dalam pengabdian masyarakat sebelum dan sesudah diberikan edukasi kepada ibu hamil aterm dalam manfaat jus kurma selama kehamilan dan persalinan. Kesimpulan pengabdian masyarakat ini ada peningkatan pengetahuan ibu hamil sebelum dan sesudah dilakukan penyuluhan manfaat jus kurma selama kehamilan dan persalinan.
Valores morais em adolescentes: a força dos afetos na contemporaneidade
Authors: Braga Maria Cecilia Bergamo , Martins Raul Aragão 
Published: December 2021

A forma de interação dos membros de uma sociedade mostra como eles veem uns aos outros, e a compreensão destas interações é um elemento importante para o trabalho educacional. Este estudo se propôs a uma discussão teórica sobre conceitos relativos ao tema da moral e da ética, e à investigação empírica de uma possível relação entre a positiva representação de si e o nível de perspectiva sociomoral de alunos do ensino médio. A base teórica do trabalho apoia-se nos estudos de sobre desenvolvimento moral de Piaget e Kohlberg. Foi investigado como 122 alunos de duas escolas (sendo uma privada de orientação religiosa e outra pública) aderem aos valores morais justiça, solidariedade, respeito e convivência democrática, e qual representação de si eles têm. As escolas situam-se em duas cidades da região noroeste do estado de São Paulo. Os alunos responderam à Escala de Valores Morais e a duas questões sobre representação de si. A aplicação dos instrumentos foi realizada de forma coletiva, na própria sala de aula dos alunos. Os resultados apontaram para uma caracterização majoritariamente sociocêntrica dos alunos e para correspondências afirmativas entre alguns dados de perfil, autorrepresentação positiva, e melhores níveis de respostas morais.
Características métricas del paladar de neonatos nacidos a término y pre-término en el Instituto Nacional Materno Perinatal
Authors: Munayco Magallanes Américo , Ocampo Escobedo Llisel Ocampo Escobedo , Cortez Marino María , Lapa Meza Maryjose 
Published: December 2021

Objetivo: Determinar las características métricas del paladar en neonatos nacidos a término y pre-término en el Instituto Nacional Materno Perinatal (INMP). Materiales y métodos: Se realizó un estudio retrospectivo de tipo transversal en el INMP en la ciudad de Lima – Perú mediante un muestreo no probabilístico por conveniencia en 60 neonatos; divididos en dos grupos: 30 neonatos nacidos a término y 30 neonatos nacidos pre-término. El registro del paladar se hizo mediante impresiones con silicona y cubetas de acrílico individualizadas, obteniéndose modelos de estudio con yeso Ortodóncico; dichos modelos fueron llevados a Tomografía Espiral Multicorte, para realizar las mediciones longitudinales, transversales y de profundidad en vistas axiales y sagitales. Resultados: En neonatos pre-término el ancho promedio del paladar fue 26,4 mm, mientras que en los neonatos a término fue 29,5 mm. La profundidad promedio del paladar de los neonatos pre-término es 6,95 mm y en neonatos a término es 7,87mm. El índice palatal promedio en los neonatos pre-término es igual a 0,26 mm y en los neonatos a término es 0,27 mm. El Índice Palatal no presenta diferencias significativas en neonatos a término y pre-término (p=0,785). Conclusiones: La profundidad del paladar en neonatos pre-término es menor que en neonatos a término. Los neonatos a término tienen el paladar más ancho y largo que los neonatos pre-término. El índice palatal es el mismo en neonatos a término y pretérmino y, no es afectado por el género y edad gestacional.
Recomendaciones para la atención de recién nacidos hijos de madre COVID-19 positivas
Authors: Dávila Aliaga Carmen Rosa , Torres Marcos Elsa , Hinojosa Perez J. Rosmary , Espinoza Vivas Ylia 
Published: December 2021

La COVID-19 fue declarada pandemia mundial por la OMS el 11 de marzo del 2020, en la actualidad hay más de 34 millones de personas infectadas en el mundo y más de un millón han fallecido1,2. Dong reportó de un total de 2,135 niños afectados solo el 1.5% en edad neonatal3.
En el Perú, al 30 de setiembre del 2020, se han reportado 818,290 infectados y 32,535 fallecidos. Según el registro de NOTI-CDC-MINSA Perú hasta el 20 de setiembre del presente año, 6183 recién nacidos sospechosos a COVID-19, representa una incidencia acumulada de 17.93 x 1000 nacimientos. Por otro lado, notificaron 313 casos positivos con PCRrt, de ellos fallecieron 24 recién nacidos4.
Los niños de todas las edades pueden enfermar con COVID-19, la mayoría no se enferman con tanta gravedad como los adultos, y algunos quizás no presenten síntomas. Los índices de hospitalización para niños han sido mucho más bajos que para los adultos5-8.
En estos momentos existen pocos datos epidemiológicos de la enfermedad en neonatos y menos aún de seguimiento de estos casos. La Red de la Sociedad Iberoamericana de Neonatología reportó que de 86 mujeres embarazadas con COVID-19, 6% de los recién nacidos fueron prematuros, 7% dieron positivo al PCRrt, ninguno falleció, 76% separó al binomio, en 95% de los casos la madre no pudo ser acompañada en el parto ni puerperio, solo 24% de las madres fueron autorizadas a amamantar9. Esta es una realidad que grafica parte de las consecuencias de la pandemia en la atención neonatal10.
СULTURAL EPOCHS AS TEXT IN LESIA UKRAINKA’S DRAMAS
Authors: Turhan Olha 
Published: December 2021

Based on Lesia Ukrainka’s dramas “Iphigenia in Tavrida”, “Cassandra”, “The Orgy”, “Ruphin and Priscilla”, and “The Stone Master”, the paper highlights peculiarities of cultural and historical codes of the Antiquity and the Middle Ages in the writer's works as well as literary manifestation of the world-view features of European and Ukrainian Modernism in the antique and medieval images and motifs.
Lesia Ukrainka reconsidered the heritage of archaic and late Antiquity, Hellenistic period, Galilee at the time of Jesus, Early Christianity, and Medieval Spain. Each of these epochs has its own dichotomy of social and biological phenomena, parameters of the world model, and dominant fundamental points.
Lesia Ukrainka’s dramas transform the material of various cultural epochs, providing polysemantic images that transfer the cosmos of a certain period into the neo-romantic and neo-classical system of images and symbols. In the dramas, the writer raised the issues recurrent in her works, such as love and sacrifice; beauty and ugliness; prophet, artist and ‘revolt of the masses’; reality and dream; good and evil; truth and benefit; nostalgia for chivalry; nostalgia for the Absolute; psychological and moral freedom and violence; spirit, soul, and body; spiritual nobility and the rule of brutes; nature and culture, etc.
Numerous issues and characters, multifunctional ontological, cultural, and historical phenomena, cultural codes, symbols, and mythologems acquire an existential meaning in the author’s dramas fitting not only into various cultural contexts but also into the modern reconsideration of mythopoetics.
Integrated Study of Transcriptome-wide m6A Methylome Reveals Novel Insights Into the Character and Function of m6A Methylation During Yak Adipocyte Differentiation
Authors: Zhang Yongfeng , Liang Chunnian , Wu Xiaoyun , Pei Jie , Guo Xian , Chu Min , Ding Xuezhi , Bao Pengjia , Kalwar Qudratullah , Yan Ping 
Published: December 2021

Yak (Bos grunniens) is considered an iconic symbol of Tibet and high altitude, but they suffer from malnutrition during the cold season that challenges the metabolism of energy. Adipocytes perform a crucial role in maintaining the energy balance, and adipocyte differentiation is a complex process involving multiple changes in the expression of genes. N6-methyladenosine (m6A) plays a dynamic role in post-transcription gene expression regulation as the most widespread mRNA modification of the higher eukaryotes. However, currently there is no research existing on the m6A transcriptome-wide map of bovine animals and their potential biological functions in adipocyte differentiation. Therefore, we performed methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) to determine the distinctions in m6A methylation and gene expression during yak adipocyte differentiation. In yak adipocyte and preadipocyte the content of m6A and m6A-associated enzymes was substantially different. In the two groups, a total of 14,710 m6A peaks and 13,388 m6A peaks were identified. For the most part, m6A peaks were enriched in stop codons, 3′-untranslated regions, and coding regions with consensus motifs of GGACU. The functional enrichment exploration displayed that differentially methylated genes participated in some of the pathways associated with adipogenic metabolism, and several candidate genes (KLF9, FOXO1, ZNF395, and UHRF1) were involved in these pathways. In addition to that, there was a positive association between m6A abundance and levels of gene expression, which displayed that m6A may play a vital role in modulating gene expression during yak adipocyte differentiation. Further, in the adipocyte group, several methylation gene protein expression levels were significantly higher than in preadipocytes. In short, it can be concluded that the current study provides a comprehensive explanation of the m6A features in the yak transcriptome, offering in-depth insights into m6A topology and associated molecular mechanisms underlying bovine adipocyte differentiation, which might be helpful for further understanding its mechanisms.
New Methylene Blue Covalently Functionalized Graphene Oxide Nanocomposite as Interfacial Material for the Electroanalysis of Hydrogen Peroxide
Authors: Chen Jifang , Gao Ziqing , Yang Ruonan , Jiang Huiling , Bai Lin , Shao Ailong , Wu Hai 
Published: December 2021

New methylene blue (NMB), a phenothiazine dye, was covalently bonded to graphene oxide (GO) using glutaraldehyde as a crosslinking agent, which was characterized by spectroscopic techniques and electrochemistry. The obtained GO–NMB nanocomposite was used as interface material to construct a novel electrochemical sensor for the determination of hydrogen peroxide (H2O2). The electrochemical sensor based on GO–NMB nanocomposite exhibited excellent electrocatalytic activity for the reduction of hydrogen peroxide (H2O2), which was also enhanced by GO within the GO–NMB nanocomposite. With the optimized experimental conditions, the developed sensor showed high sensitivity (79.4 μA mM−1 cm−2) for electrocatalytic determination of H2O2 at the applied potential of −0.50 V in the concentration range of 0.000333 to 2.28 mΜ. The low limit of detection (1.35 μM), good reproducibility, and high stability of the sensor suggests that the electrochemical sensor based on the GO–NMB nanocomposite possesses obvious advantages, which paves a new avenue to functionalize GO for obtaining electrode interface materials.
Using the More Than Words Program With Chinese Families: A Case-Control Study
Authors: Lok Jasper S. Y. , Qi Xin , To Carol K. S. 
Published: December 2021

This study investigated the effectiveness of the Hanen More Than Words® (HMTW) program amongst parents of children with autism spectrum disorder (ASD) in Hong Kong. In this prospective cohort study, 31 Cantonese-speaking young children with ASD and their parents were divided into either the HMTW group (n= 26) or a control group (n= 5). The HMTW intervention was provided over 11 weeks. The children’s communication abilities were measured prior to the intervention (Time 1) and 1 month after the end of the intervention (Time 2), and the results were compared between the two groups. The parents’ attributes and demographic information were measured at Time 1. The results showed a significant increase in children’s communication and social skills in the HMTW group compared with the control group. Children of parents with lower levels of Time 1 parenting self-efficacy exhibited facilitated growth in communication and social skills. These findings provide evidence of the effectiveness of the HMTW program in a Chinese cultural setting and demonstrate an important link between parenting self-efficacy and the effectiveness of the HMTW program.
Holocene Environmental Changes Inferred From an Aeolian-Palaeosol-Lacustrine Profile in the Mu Us Desert, Northern China
Authors: Liu Xiaokang , Lu Ruijie , Ding Zhiyong , Lyu Zhiqiang , Li Yijing , Dong Zhibao 
Published: December 2021

An excavated profile of aeolian-palaeosol-lacustrine sediments (the Wapianliang profile), located at the southeastern part of the Mu Us Desert, Northern China, was studied to reconstruct regional Holocene environmental changes. A chronology was established based on three AMS 14C and two OSL dates, and variations in the lithology and grain size, magnetic susceptibility, soil micromorphology, and chemical elements were used to explore the regional depositional environments during the Holocene. The results showed that since around 14 ka BP, this region had experienced seven alternations of wetting and drying. A shallow lake, which was identified by celadon lacustrine sediments with sporadic freshwater gastropod fossils, occurred in this area from around 13.0 ka BP to 9.9 ka BP. There existed two obvious intervals of soil formation, inferred from the environmental proxies of the palaeosol/sandy palaeosol layers, with relatively fine average grain-size, high magnetic susceptibility value, remarkable pedogenesis features, and strong chemical weathering, in particular, a well-developed palaeosol layer dating from the middle Holocene (8.6 ka BP to 4.2 ka BP). A weakly-developed palaeosol layer (from around 1.2 ka BP) at the upper part of the profile is possibly an indication of the Medieval Warm Period. This implies a forest steppe environment at both of these sedimentary stages. After 0.9 ka BP, a desert environment returned, analogous to before around 13.0 ± 1.4 ka BP, between 9.9 ± 1.1 ka BP to 8.6 ka BP, and between 4.2 ka BP to 1.6 ka BP, indicating the aggravation of aeolian activity and the expansion of mobile sand dunes. The variations in sedimentary environments were mainly triggered by changes in the East Asian Summer Monsoon (EASM).
Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
Authors: He Lei , Zhang Jinghan , Yu Tengfei , Du Yue , Liu Xinyao , He Wen 
Published: December 2021

BackgroundTranscranial sonography (TCS) is a convenient tool for detecting certain brain diseases, such as brain tumors. Few studies have reported on the use of TCS in the area of Sella turcica. The accuracy and repeatability of Sella turcica with or without pituitary tumor is not clear.PurposeThis study aimed to investigate the feasibility and accuracy of TCS to measure the size of Sella turcica according to the measurement in MRI and determine its diagnostic performance in individuals with pituitary tumor.Materials and MethodsIn this cross-sectional comparative study, healthy volunteers and patients with pituitary tumor were enrolled for examination of TCS and MRI between October 2020 and July 2021. The transverse diameter (D1, cm) of Sella turcica and the volume of the pituitary tumor were measured by TCS and MRI, respectively, and compared by using Student’s t-test or Mann–Whitney test, using the receiver operating characteristic (ROC) curve to analyze the diagnostic value of D1 in TCS for pituitary tumor.ResultsA total of 75 healthy volunteers and 51 patients with pituitary tumor were evaluated. In healthy volunteers, the mean D1 was 1.30 ± 0.35 (range, 0.82–3.22) by TCS and 1.32 ± 0.29 (range, 0.94–3.02) by MRI (P = 0.054). In patients with pituitary tumor, the mean D1 was 2.0 ± 0.65 (range, 0.90–3.48) by TCS and 2.42 ± 1.0 (range, 0.80–4.70) by MRI (P = 0.000). The median measurement volume was 4.41 and 6.59 cm3 in TCS and MR, respectively (P = 0.000). The mean D1 was 1.31 ± 0.35 in healthy volunteers and 2.0 ± 0.65 cm in patients with pituitary tumor (P = 0.000). In the ROC curve analysis, the area under the curve was 0.836, and the optimal cutoff value (1.56) exhibited a sensitivity and specificity of 67.31 and 88.0%, respectively.ConclusionThe consistency between the two imaging technologies performed well in D1 measurement, while the volume of the pituitary tumor was smaller as assessed by TCS than by MRI. D1 in TCS had good diagnostic performance in pituitary tumor.
Health-Related Quality of Life of Children and Adolescents With Congenital Hyperinsulinism – A Scoping Review
Authors: Kristensen Kaja , Quitmann Julia , Witt Stefanie 
Published: December 2021

IntroductionDespite improvements in diagnosis and therapeutic advances in treatment, congenital hyperinsulinism (CHI) remains a severe disease with high patient impairment. We aimed to review the literature on Health-related Quality of Life in children and adolescents with congenital hyperinsulinism and summarize the findings.Materials and MethodsFor this scoping review, a literature search was conducted in PubMed and Web of Science in May 2021. Inclusion and exclusion criteria for the selection of articles were defined a priori.ResultsTwo hundred and forty-five (245) articles were identified through the search and screened on the basis of title and abstract. The full texts of forty articles were then assessed. Finally, four articles (published 2012-2020) describing Health-related Quality of Life in children and adolescents with congenital hyperinsulinism were included. The study designs were heterogeneous and included cross-sectional observational studies (n=2), clinical trials (n =1), and case reports (n=1) with different sample sizes. Three studies were conducted in European countries and one in Japan. The results for Health-related Quality of Life revealed inconsistencies.ConclusionThere are only a few studies looking at Health-related Quality of Life in children and adolescents with congenital hyperinsulinism. To gain a comprehensive understanding of the impact of congenital hyperinsulinism on Health-related Quality of Life in children and adolescents, it is necessary to use both generic and condition-specific instruments to measure Health-related Quality of Life of young patients in larger samples, to collect longitudinal data, and to consider qualitative research approaches.
Evaluating the Effects of Symptom Monitoring on Menopausal Health Outcomes: A Systematic Review and Meta-Analysis
Authors: Andrews Robin , Hale Gabrielle , John Bev , Lancastle Deborah 
Published: December 2021

Evidence suggests that monitoring and appraising symptoms can result in increased engagement in medical help-seeking, improved patient-doctor communication, and reductions in symptom prevalence and severity. To date, no systematic reviews have investigated whether symptom monitoring could be a useful intervention for menopausal women. This review explored whether symptom monitoring could improve menopausal symptoms and facilitate health-related behaviours. Results suggested that symptom monitoring was related to improvements in menopausal symptoms, patient-doctor communication and medical decision-making, heightened health awareness, and stronger engagement in setting treatment goals. Meta-analyses indicated large effects for the prolonged use of symptom diaries on hot flush frequencies. Between April 2019 and April 2021, PsychInfo, EMBASE, MEDLINE, CINAHL, Cochrane, ProQuest, PsychArticles, Scopus, and Web of Science were searched. Eighteen studies met the eligibility criteria and contributed data from 1,718 participants. Included studies quantitatively or qualitatively measured the impact of symptom monitoring on menopausal populations and symptoms. Research was narratively synthesised using thematic methods, 3 studies were examined via meta-analysis. Key themes suggest that symptom monitoring is related to improvements in menopausal symptoms, improved patient-doctor communication and medical decision-making, increased health awareness, and stronger engagement in goal-setting behaviours. Meta-analysis results indicated large effects for the prolonged use of symptom diaries on hot flush frequency: 0.73 [0.57, 0.90]. This review is limited due to the low number of studies eligible for inclusion, many of which lacked methodological quality. These results indicate that symptom monitoring has potential as an effective health intervention for women with menopausal symptoms. This intervention may be beneficial within healthcare settings, in order to improve patient-doctor relations and adherence to treatment regimes. However, findings are preliminary and quality assessments suggest high risk of bias. Thus, further research is needed to support these promising outcomes.Systematic Review Registration Number:https://www.crd.york.ac.uk/prospero/display_record.php?, PROSPERO, identifier: CRD42019146270.