bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEGs and Biological Process Profiling to screen the novel biomarkers associated with both Uterine Leiomyomas and Uterine leiomyosarcomas
Authors: UPADHYAY Sonal , Gupta Deepali , DUBEY Pawan K. , BHUSHAN Ravi 
Published: May 2021

Abstract
Background

Uterine Leiomyomas (ULM) or Uterine fibroid are benign lesion of unspecified aetiology and still there is dearth of prognostic biomarkers for diagnosis. The aim of this present study is to explore the novel biomarkers to be associated with Uterine Leiomyomas (ULM) and Uterine leiomyosarcomas (ULMS) that were responsible for their pathogenicity.
Methods

The microarray dataset (GSEID:GSE64763) was retrieved from the Gene Expression Omnibus database. Data preprocessing and differential gene expression analysis was performed. Principal Component Analysis (PCA) plot and heat map for ULM and ULMS were constructed for respective differentially expressed genes. The DEGs were further intersected to find the common DEGs in ULM and ULMS. Based upon STRING v 10.5, protein- protein interaction network was constructed. Further, Gene Ontology (GO) and KEGG pathway enrichment analysis were also performed to dissect out possible function and pathways.
Results

A total of 50 significant DEGs for ULM while 321 DEGs for ULMS have been identified with their official gene symbol. Between ULM and ULMS, total 14 common DEGs were identified of which 8 were up-regulated while 6 were down-regulated. Comparison of DEGs list with annotated gene list obtained from OMIM and Gene Cards, lead to identification of only 3 known disease genes (RAD51B, ESR1 and PDGFRA) while SHOX2, TNN and COL11A1 genes were found to be novel biomarkers in ULM and ULMS both. Gene ontology and KEGG pathway enrichment analysis of common novel and known candidate genes led to the identification of several important processes and pathways like ECM receptor interactions and Focal adhesion.
Conclusions

SHOX2, TNN and COL11A1 are the novel biomarkers related to both ULM and ULMS disease and have been found to be associated with ECM receptor interactions and Focal adhesion like pathways and hence can serve as novel diagnostic as well as therapeutic targets.
Combination Chemoradiotherapy with Temozolomide, Vincristine, and Interferon-β Might Improve Outcomes Regardless of O6-Methyl-Guanine-DNA-Methyltransferase (MGMT) Promoter Methylation Status in Newly Glioblastoma
Authors: Asano Kenichiro , Fumoto Toshio , Hasegawa Seiko , Suzuki Naoya , Akasaka Kenichi , Katayama Kosuke , Kamataki Akihisa , Kurose Akira , Ohkuma Hiroki 
Published: May 2021

Abstract
Background: This investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction combination chemoradiotherapy for newly glioblastoma and also the effectiveness of long-term maintenance therapy with temozolomide (TMZ) plus interferon (IFN)-b. Methods: The initial induction combination chemoradiotherapy comprised radiotherapy plus TMZ plus vincristine plus IFN-b. Maintenance chemotherapy comprised monthly TMZ, continued for 24–50 cycles, plus weekly IFN-b continued for as long as possible. The primary endpoint was 2-year overall survival (2y-OS). A 2y-OS exceeding 38%, with upper limit of the 95% confidence interval (CI) exceeding 31.7%, and lower limit of the 95%CI exceeding 21.2% as compared to historical controls, was considered as the criterion for treatment effectiveness. Secondary endpoints were median progression-free survival (mPFS), median OS (mOS), 5-year OS rate (5y-OS), and mPFS and mOS classified according to MGMT promoter methylation status. Results: Forty-seven patients were analyzed. The 2y-OS was 40.7% (95%CI, 27.5–55.4%), suggesting that this protocol was effective. The mPFS and mOS were 11.0 months and 18.0 months, respectively, and 5y-OS was 20.3% (95%CI, 11.0–34.6%). The mPFS in groups with and without MGMT promoter methylation in the tumor was 10.0 months and 11.0 months (p=0.59), respectively, and mOS was 24.0 months and 18.0 months (p=0.88), respectively. The frequency of grade 3/4 neutropenia was 19.1%.Conclusions: These results suggest the efficacy of induction multicombination chemoradiotherapy, as well as of long-term maintenance therapy comprising TMZ plus IFN-b. This protocol would have the possibility to deny the MGMT promoter methylation status as prognostic factors.Trial registration: The University Hospital Medical Information Network (Number UMIN000040599)
Association of lung consolidation with clinical prognosis in children with Mycoplasma pneumoniae pneumonia: a retrospective study
Authors: Chu Caiting , Wang Lijun , Li Huajun , Xu Shanshan , Zhang Liya , Liu Quanhua , Zhang Xi , Zhang Weixi , Li Wenhua , Huang Lisu 
Published: May 2021

Abstract
Objectives

Lung consolidation is common in patients with Mycoplasma pneumoniae pneumonia (MPP). In this study, we aimed to investigate whether this lung lesion associated with the severity and prognosis of MPP.
Methods

Clinical experts reassessed and collected the clinical characteristics, imaging features, and laboratory examination of 752 hospitalized children with MPP who received low-dose computerized tomography (CT) examination between August 2014 and July 2019. We evaluated the impact of lobar consolidation on the fever duration and length of hospital stay using Kaplan-Meier analysis and COX model. The relationship between lobar consolidation and inflammatory markers was also determined, as well as hospital charges.
Results

Among the 752 patients included, 90.3% (679/752) presented lung consolidation, 25.1% (189/752) with 2 or more lobar consolidation, and 16.2% (122/752) patients developed severe MPP (SMPP). Beyond pleural effusion, lobar consolidation had the highest risk of SMPP among low-dose CT imaging-based evidence. Compared with 0 and 1 lobar consolidation, 2 lobes, 3 lobes, and 4 lobes were associated with a 1-fold, 3.1-fold, and 7.5-fold increased risk of SMPP (OR 2.0 [95% CI 1.3–3.2], OR 4.1 [95% CI 2.0–8.5], OR 8.5 [95% CI 2.2–32.6]). The length of stay and fever duration were prolonged correspondingly with increase of number of lobar consolidation, as were hospital charges.
Conclusion

Lobar consolidation is a stable and reliable CT feature for assessing of severity of illness and clinical prognosis for children with MPP.
COVID-19 Data Published by Turkey is Fake or Not?
Authors: Guliyev Hasraddin 
Published: May 2021

Abstract
Turkey attempt to control the fast-rising number of coronavirus cases and deaths since the spread of coronavirus disease 2019 (COVID-19) in every country. Likewise, researchers from different fields have been an effort to explore COVID-19 with distinctive aspects for minimizing the cost of a pandemic on the economy and social life. We know that is impossible reliable and unbiased results of studies without accurate data. Thus, if we gather inadequate data and analysis it, we will be faulty decisions and make policies. For this reason, Benford's Law may be useful for assessing the effects of the current control interventions and may be able to answer the question, ‘‘How flat is flat enough?’’. In this study, we explore whether the COVID-19 data published by Turkey is fake or not with Benford's Law.
DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma
Authors: Keane Simon , de Weerd Hendrik A. , Ejeskär Katarina 
Published: May 2021

Abstract
Background: In primary neuroblastoma, deletions on chromosome 11q are known to result in an increase in the total number of chromosomal breaks. Microhomology mediated-end joining (MMEJ) is an error-prone pathway for DNA double-strand break repair that is often upregulated in cancer. DLG2, a candidate tumor suppressor gene on chromosome 11q, has previously been implicated in DNA repair.Methods: We evaluated an association between MMEJ gene expression and neuroblastoma patient outcome, risk categorization, and 11q status using publicly available microarray data from independent neuroblastoma patient datasets. Functional studies were conducted using comet assay and H2AX phosphorylation in neuroblastoma cell lines and in the fruit fly with UVC-induced DNA breaks. Results: We show that the MMEJ genes PARP1 and FEN1 are over expressed in neuroblastoma and restoration of DLG2 impairs their gene and protein expression. When exposed to UVC radiation, cells with DLG2 over expression show less DNA fragmentation and induce apoptosis in a p53 S46 dependent manner. We could also confirm that DLG2 expression results in CHK1 phosphorylation consistent with previous reports of G2/M maintenance. Conclusions: Taken together, we show that DLG2 expression increases p53 mediated apoptosis in response to genotoxicity, by maintaining S317 CHK1 phosphorylation and reducing the DNA replication machinery.
Die Väterbeteiligung in Europa und der Schweiz — Die Rolle der Väter für mehr Gleichberechtigung
Authors: Lütz Fabian 
Published: May 2021

Nachdem die Europäische Union (EU) mit der Verabschiedung der Work-Life Balance Richtlinie (WLB-RL) zum ersten Mal im EU-Recht einen zehntägigen Vaterschaftsurlaub verankert hat und die Schweiz am 27. September 2020 im Rahmen der Volksabstimmung ebenfalls einen zehntägigen Vaterschaftsurlaub angenommen hat, lohnt sich ein Blick auf beide Rechtssysteme, um Gemeinsamkeiten und Unterschiede herauszuarbeiten. Der vorliegende Beitrag verfolgt einen rechtlichen und verhaltensökonomischen Ansatz und analysiert das europäische und schweizerische Recht vor dem Hintergrund des Zielsder Gleichstellung von Männern und Frauen. Schliesslich wagt er einen Ausblick und arbeitet rechtsvergleichend Reformmöglichkeiten heraus, die sich jeweils aus dem europäischen und Schweizer Recht für das jeweils andere Rechtssystem ergeben.
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Suite à l’inscription d’un congé de paternité de dix jours dans le droit de l’Union européenne, par l’adoption de la directive concernant l’équilibre entre vie professionnelle et vie privée (dite « Work-Life Balance »), et dans le droit suisse à l’issue du référendum du 27 septembre 2020, une analyse des similitudes et différences entre ces deux systèmes juridiques s’avère judicieuse. Cette contribution adopte une approche juridique et comportementale qui analyse les droits européen et suisse dans le contexte de l’objectif de l’égalité entre les hommes et les femmes. Enfin, il ouvre une perspective et suggère, sur la base de cette approche comparative, des possibilités de réforme, respectivement pour les systèmes européen et suisse.
Results of using 3-D simulation methods in treatment of midfacial fractures
Authors: Khudyk Anton , Grigorov Sergey 
Published: May 2021

The article publishes the results of treatment of 27 patients with fractures of the face middle area, of which 14 used standard titanium mini-plates to reposition the fragments, and 13 – individual 3D simulated titanium mini-plates / grids. Before and after treatment, its effectiveness was assessed by the values of the displacements of bone fragments and the index of the visual-analog scale, which allows determining the functional and cosmetic effect of the surgery. It was found that the use of individual 3D simulated titanium mini-plates / grids allowed obtaining in 85 % of patients displacements not exceeding 3 mm. In 72 % of patients in whom standard titanium mini-plates were used, the displacement after surgery was 3.1–6 mm, which is significantly greater than in the group with individual modeling of structures.
On the 7th day after surgery in the first group (treatment with standard mini-plates), the index on the visual-analog scale was 11 (7; 13), which was significantly (p=0.00147) less than before surgery. In the second group (treatment using individual 3D simulated titanium mini-plates / grids) the index on the visual analog scale was 4 (6; 8) points, which was significantly (Z=3.3; p=0.00098) less than before surgery. Comparison of the visual-analog scale of the first and second groups on the 7th day after surgery revealed the presence of significant (U=2.47; p=0.013) differences. The obtained results testify to the greater efficiency of individual 3D modeled titanium mini-plates / grids in comparison with standard titanium mini-plates.
The object of the research: fractures of the middle area of the face. Comparison of the visual-analog scale of the first and second groups on the 7th day after surgery revealed the presence of significant (U=2.47; p=0.013) differences.
Investigated problem: the comparative evaluation of the effectiveness of the middle area of the face fractures treatment using individual 3D simulated titanium mini-plates / grids and standard titanium mini-plates.
The main scientific results: Optimizing the treatment of fractures of the face middle area will help to achieve good cosmetic and functional results.
The area of practical use of the research results: Department of Surgical Dentistry and Maxillofacial Surgery.
Innovative technological product: The proposed technique using individual 3D-simulated titanium miniplates will help to optimize the treatment of patients with traumatic fractures of the face middle area.
Scope of the innovative technological product: Clinical practice.
Method of evaluation of the minimal sample size for acoustical signal therapy monitored via electroencephalographic activity of human brain
Authors: Pareniuk Dmytro 
Published: May 2021

The aim of the study. Improvement of the preparation to the acoustical signal therapy test or experiment of electroencephalographic activity of human brain and validation of the specified test results.
The problem to be solved. Estimation of the minimal possible sample size for maintaining needed research accuracy in the research field of the electroencephalographic activity of human brain via monitoring of the brainwave patterns during exposure to the musical signal.
Main scientific results. New method for selection minimal passable sample size for brainwave pattern studies is presented. Example of application of method for one rhythm of the brainwaves (delta-rhythm) is shown. Perspective way of obtaining clinically valuable differences between test group results was acquired. Differences between mean values for groups of results of different types of music and stress factor exposure are presented.
The area of practical use of the research results. Research facilities dedicated to the study of electroencephalographic activity of human brain and medical facilities and institutions, dedicated to the treatment of pathologies of the central nervous system, brain damage, stress, and progressive post-stress action psychological state restoration.
An innovative technological product. Dedicated method for quick estimation of minimal passable sample size for brainwave pattern studies, which is recommended for usage in the studies of the implementation of music therapy.
The area of application of an innovative technological product. Electroencephalographic activity of human brain study via brainwave pattern research. Clinical practice of application of a music therapy.
Comparison of distance education problems during the COVID-19 pandemic
Authors: Klochko Vitalii , Kulynych Tetiana , Chuiko Natalia , Postolna Natalia , Holovanova Olena 
Published: May 2021

The object of research: distance learning in higher educational institutions of Ukraine and the world during the COVID-19 pandemic.
Investigated problem: building a higher education system during the COVID-19 pandemic, capable of quickly adapting to adverse conditions and providing a high level of training.
The main scientific results: explored trends regarding the study of the impact of the pandemic on higher education, the effectiveness of distance education. Analyzed Ukrainian studies of distance education in universities. Held by students of the KNTEU Kharkiv Trade and Economic College. Based on the research results, conclusions and recommendations were made regarding the improvement of the quality of distance education in the field of higher education.
The area of practical use of the research results: higher education and professional education organizations.
Technological innovation: identified the problems of distance education during the COVID-19 pandemic, based on them, recommendations were developed to improve the quality of education in higher educational institutions of Ukraine.
Scope of application for technological innovation: practical activity in higher education and relations with stakeholders of educational organizations.
Development of main principles and tasks of Jewish national movement for revival of the state by Vladimir Zhabotinsky
Authors: Radchenko Liudmyla 
Published: May 2021

The social and political activity of V. Zhabotinsky as a Jewish politician, a famous Zionist, the founder of modern Israel and a multifaceted personality. Its focus on the consolidation of Jewish political and social organizations, the development of a common platform on the basic principles and objectives of the Jewish national movement for the revival of statehood and the involvement of Jews from around the world in this process is substantiated. V. Zhabotinsky's commitment to the Ukrainian national movement is proved.
The object of research: V. Zhabotinsky as a great political figure of the Jewish and Ukrainian national movement.
Investigated problem: V. Zhabotinsky contribution to the consolidation of Jewish political and public organizations, to the development of Zionist theory, the basic principles and tasks of the Jewish national movement for the revival of the independent Jewish state of Israel and the solution of the Ukrainian national question.
The main scientific results: based on the analysis of socio-political activities and creative achievements of V. Zhabotinsky as a Jewish politician, his focus on defining a common platform on the basic principles and tasks of the Jewish national movement for the revival of statehood, involving Jews from around the world. V. Zhabotinsky's commitment to the Ukrainian national movement was revealed.
The area of practical use of the research results: determined by the suitability for practical use of modern Jewish political and public organizations to preserve Jewish national identity, ideology and organization of the revisionist movement, as well as to address the Ukrainian issue of bilateral relations, understanding nationalism as a great life idea has nothing to do with chauvinism, racism or any form of ethical supremacy.
The results can be used in the development and teaching of courses: "World History" and "History of Ukraine".
Innovative technological product: on the basis of numerous sources and materials, some of which are introduced into scientific circulation for the first time, the V. Zhabotinsky Institute (Tel Aviv) has filled a significant gap in V. Zhabotinsky 's contribution as a great figure of the Jewish national movement. His commitment to the Ukrainian national movement is substantiated, the myth of eternal antagonism between Jews and Ukrainians is refuted, arguing that the two people have lived on Ukrainian lands for thousands of years.
Scope of the innovative technological product: theoretical research, development of Zionist theory and practice of preserving Jewish national identity, ideology and organization of the revisionist movement, solution of the Ukrainian national question.
Kharkiv organization of the CP (b) U: a study of the formation of totalitarian principles of internal party life (1920-1929)
Authors: Redka Sergiy , Yaremchuk Nadiia , Prykhodko Tetiana , Zolotoverkha Viktoriia , Borzilo Lesia 
Published: May 2021

The object of research: Kharkiv organization of the CP (b) U as a component of the institutions of the political system of Ukraine.
Investigated problem : The article depicts the process of transformation of the party organization of the Communist Party of the Bolsheviks of Ukraine of the Kharkiv province into a totalitarian organization.
Main scientific results: From the very beginning, Communist Party of the Bolsheviks of Ukraine of the Kharkiv province was created as an undemocratic organization. But in the early 1920s, the internal party life of the party organization was characterized by some features of democracy. After the civil war, some communists demanded greater freedom of criticism, the initiative of the masses, and the fight against bureaucracy, but the opposition in the party organization, in contrast to the all-Union center, did not have an ideological platform. They were dissatisfied with the low financial status of ordinary communists and the privileges of the party nomenclature. The party apparatus resisted attempts to democratize party life, and ordinary communists were unable to resist this process. As a result, the party organization of Kharkiv region was transformed into a totalitarian organization, which was characterized by unanimity, intolerance of criticism, strict centralization, lack of election, powerlessness of ordinary members and uncontrolled power of the party apparatus.
Field of practical usage of research results: determined by suitability for use in the field of the modern state formation by politicians, parties, public organizations, state institutions, and the media.
Innovative technological product: on the basis of numerous archival materials, many of which are introduced into scientific circulation for the first time, a significant gap has been filled in the ideas about the process formation of totalitarian principles of internal party life at the regional level, namely in Kharkiv region.
Field of application of innovative technological product: the practice of forming, implementing and improving the system of state regulation by politic parties.
Biochemical composition of vegetable raw materials and the impact of dosage on the properties of processed cheese
Authors: Tlevlessova Dinara , Alimardanova Mariam , Kazhymurat Assemay 
Published: May 2021

The object of research is the cream cheese, elaborated using vegetable raw materials.
Investigated problem: This article provides information on the biochemical composition of leaves of A. odorum. The leaves of wild onions revealed a high content of vitamin C, macro- and microelements and other biologically active substances, indicating high nutritional and vitamin value and prospects of these species for use as fillers in the dairy industry.
The main scientific results: A. odorum refers to green vegetable plants, rich enough variety of biologically active substances. Unlike other perennial species of onion, A. odorum characterized by low protein content (1.1–1.8 %) and a relatively high solids content (in the bulb up to 17 % in the leaves 10,5–11,3 %), sugars (10,9–12,1 %).
The area of practical use of the research results: There will be researched a possibility of Allium odorum usage as an addition for new processed cheese production and an influence of plant raw material dosage on structure of the processed cheese.
Innovative technological product: Products developed within the framework of integrated technology are distinguished by high quality, nutritional value, safety, preservation of special nutrients: essential amino acids, fatty acids, omega 6 vitamins, bioflavonoids. The recipe solutions about the elements of innovative complex technologies are reflected in the patents that are included in the Derwent database.
Scope of the innovative technological product: Plant raw materials can be used both in pharmaceuticals to isolate saponins and to increase the nutritional and biological value of food products. In this article, we considered it in the production of processed cheeses, but it can be used as a seasoning for dishes. Content of inulin, quercetin, saponins, vitamin K, selenium, etc. makes this source very promising, it also has fungicidal properties and allows you to increase the shelf life of food products.