bluuebunny/crossref_metadata_2025_split huggingface dataset:
microRNAs and Gene–Environment Interactions in Autism: Effects of Prenatal Maternal Stress and the SERT Gene on Maternal microRNA Expression
Authors: Beversdorf David Q. , Shah Ayten , Jhin Allison , Noel-MacDonnell Janelle , Hecht Patrick , Ferguson Bradley J. , Bruce Danielle , Tilley Michael , Talebizadeh Zohreh 
Published: July 2021

Background:Genetics and environment both are critical in autism spectrum disorder (ASD), but their interaction (G × E) is less understood. Numerous studies have shown higher incidence of stress exposures during pregnancies with children later diagnosed with ASD. However, many stress-exposed mothers have unaffected children. The serotonin transporter (SERT) gene affects stress reactivity. Two independent samples have shown that the association between maternal stress exposure and ASD is greatest with maternal presence of theSERTshort (S)-allele (deletion in the promoter region). MicroRNAs play a regulatory role in the serotonergic pathway and in prenatal stress and are therefore potential mechanistic targets in this setting.Design/methods:We profiled microRNA expression in blood from mothers of children with ASD, with known stress exposure during pregnancy. Samples were divided into groups based onSERTgenotypes (LL/LS/SS) and prenatal stress level (high/low).Results:Two thousand five hundred mature microRNAs were examined. The ANOVA analysis showed differential expression (DE) of 119 microRNAs; 90 were DE in high- vs. low-stress groups (stress-dependent). Two (miR-1224-5p, miR-331-3p) were recently reported by our group to exhibit stress-dependent expression in rodent brain samples from embryos exposed to prenatal stress. Another, miR-145-5p, is associated with maternal stress. AcrossSERTgenotypes, with high stress exposure, 20 significantly DE microRNAs were detected, five were stress-dependent. These microRNAs may be candidates for stress ×SERTgenotype interactions. This is remarkable as these changes were from mothers several years after stress-exposed pregnancies.Conclusions:Our study provides evidence for epigenetic alterations in relation to a G × E model (prenatal maternal stress ×SERTgene) in ASD.
Exploring Feasibility of Multivariate Deep Learning Models in Predicting COVID-19 Epidemic
Authors: Chen Shi , Paul Rajib , Janies Daniel , Murphy Keith , Feng Tinghao , Thill Jean-Claude 
Published: July 2021

Background: Mathematical models are powerful tools to study COVID-19. However, one fundamental challenge in current modeling approaches is the lack of accurate and comprehensive data. Complex epidemiological systems such as COVID-19 are especially challenging to the commonly used mechanistic model when our understanding of this pandemic rapidly refreshes.Objective: We aim to develop a data-driven workflow to extract, process, and develop deep learning (DL) methods to model the COVID-19 epidemic. We provide an alternative modeling approach to complement the current mechanistic modeling paradigm.Method: We extensively searched, extracted, and annotated relevant datasets from over 60 official press releases in Hubei, China, in 2020. Multivariate long short-term memory (LSTM) models were developed with different architectures to track and predict multivariate COVID-19 time series for 1, 2, and 3 days ahead. As a comparison, univariate LSTMs were also developed to track new cases, total cases, and new deaths.Results: A comprehensive dataset with 10 variables was retrieved and processed for 125 days in Hubei. Multivariate LSTM had reasonably good predictability on new deaths, hospitalization of both severe and critical patients, total discharges, and total monitored in hospital. Multivariate LSTM showed better results for new and total cases, and new deaths for 1-day-ahead prediction than univariate counterparts, but not for 2-day and 3-day-ahead predictions. Besides, more complex LSTM architecture seemed not to increase overall predictability in this study.Conclusion: This study demonstrates the feasibility of DL models to complement current mechanistic approaches when the exact epidemiological mechanisms are still under investigation.
Multi-State Analysis of the Impact of Childhood Starvation on the Healthy Life Expectancy of the Elderly in China
Authors: Dong Huiling , Du Chunjing , Wu Bingyi , Wu Qunhong 
Published: July 2021

Background: Child malnutrition is not only common in developing countries but also an important issue faced by developed countries. This study aimed to explore the influence and degree of childhood starvation on the health of the elderly, which provides a reference for formulating health-related policies under the concept of full lifecycle health.Methods: Based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2008, 2011, and 2014, this study took a total of 13,185 elderly people aged 65–99 years as the target population. By IMaCH software, with gender and income level as the control variables, the average life expectancy and healthy life expectancy of the elderly were measured. The x2test was used to explore the differences in the socioeconomic status of elderly people with or without starvation in childhood. Statistical differences between average life expectancy and healthy life expectancy were analyzed by rank tests.Results: (1) The results showed that there was a statistically significant difference in age, gender, residency, education level, and income level between the groups with or without starvation (P &lt; 0.05). (2) Transition probabilities in health–disability, health–death, and disability–death all showed an upward trend with age (P &lt; 0.05), where the elderly who experienced starvation in childhood were higher than those without such an experience (P &lt; 0.05). However, the probability of disability–health recovery showed a downward trend with age (P &lt; 0.05), in which the elderly who experienced starvation in childhood were lower than those without starvation (P &lt; 0.05). (3) For the elderly who experienced starvation in childhood, the health indicators of the average life expectancy, healthy life expectancy, and healthy life expectancy proportion accounted for the remaining life were lower than those of the elderly without childhood starvation (P &lt; 0.05).Conclusions: The average life expectancy and healthy life expectancy of the elderly with childhood starvation are lower than those without childhood starvation. It shows that the negative impact of childhood starvation on health through the life course till old age has a persistent negative cumulative effect on the quantity and quality of life. Therefore, it is important to pay attention to the nutritional status of children in poor families from the perspective of social policymaking.
Correlated Imaging of the Equine Hyoid Apparatus Using CT, Micro-CT, and Histology
Authors: Hartl Bettina , Egerbacher Monika , Kneissl Sibylle Maria 
Published: July 2021

Background: Detailed radiological evaluation of the normal hyoid apparatus by computed tomography (CT) has not yet been conducted. Thus, it is unclear what type of junction connects the different parts of the equine hyoid apparatus.Objectives: To describe the normal CT anatomy of the equine hyoid apparatus, and to determine the junction type that connects the different parts of the hyoid apparatus.Study Design: Combination of retrospective study and prospective cadaver study.Methods: The medical records of horses that underwent head CT scans from 2009 to 2018 were retrieved. Inclusion criteria for the CT scans were visibility of at least two of the four junctions of the hyoid apparatus. CT images were analyzed in three different planes. Additionally, 10 cadaver heads were processed using CT, micro-CT of selected joints, and histology of all joints.Results: CT scans of 200 horses fulfilled the inclusion criteria. The tympanohyoid cartilage consisted of hyaline cartilage. Areas of mineralization within the cartilage were visible on CT scans as early as 2 years of age. The epihyoid was not fused with the stylohyoid in one-third of the horses. All horses younger than 2.5 years showed three ossification centers of the basihyoid, and all horses younger than 1.5 years had a non-fullydeveloped lingual process. In total, 10 of 11 horses between 1.5 and 3 years had separate ossification centers of the lingual process. We found a synchondrosis between the styloid process and the stylohyoid bone. The basihyoid and thyrohyoid, as well as the stylohyoid and epiyhoid were connected by a synostosis in two-thirds of the horses. The remaining parts were connected to one another by synovial joints.Main limitations: The junctions studied by histologic examination were from older horses, therefore growing patterns of different bones could not be totally clarified.Conclusion: The temporohyoid joint is a synchondrosis. The epihyoid is an ossification center of the stylohyoid and fuses with the stylohyoid in two-thirds of horses. The lingual process has a separate ossification center.
PRODUKSI KONTEN VISUAL DAN AUDIOVISUAL MEDIA SOSIAL LEMBAGA SENSOR FILM
Authors: Thifalia Naurah , Susanti Santi 
Published: July 2021

Indonesian Film Censorship Institution (Lembaga Sensor Film/LSF) uses the existence of social media to increase public knowledge about the LSF's role in the world of Indonesian cinema. As a government agency, LSF uses social media to share, increase public participation, collaboration, and assume the risk of fake news. Through social media, LSF intends to build an image, and educate the public to protect against the negative effects of film and promote the Indonesian film industry. This research reveals the content production on social media platforms used by the Film Censorship Institution (LSF) to convey information to the public. This study uses a qualitative method with a case study approach. Interviews, observation used to collect data, while literature review, and documents relevant to the research used as secondary data. Data analyzed using interactive data analysis techniques from Miles & Huberman. The results showed LSF uses Instagram, Facebook, and Twitter to convey visual and audiovisual information to the public. The visual content produces in four stages, ideas, visualization, revision, and final artwork (publication). The audiovisual content organizes in three stages, pre-production, production, and post-production. Changes in social media content increased LSF's Instagram, Twitter, and Facebook followers in six months.
Keywords: content, social media, visual, audiovisual, film industry.
Sistem Komunikasi Pemerintah Provinsi Papua dalam Penyusunan Rencana Aksi Daerah pada Program Sustainable Development Goals (SDGs)”
Authors: Mogot Yuni Dahlia , Husnita Husnita 
Published: July 2021

Sustainable Development Goals (SDGs) merupakan program pembangunan berkelanjutan yang saat ini dilaksanakan secara global di seluruh dunia sampai dengan tahun 2030 mendatang. Indonesia sebagai anggota PBB berkomitmen untuk mendukung program tersebut dengan diterbitkannya Peraturan Presiden No. 59 Tahun 2017 tentang SDGs dan tindak lanjutnya. Berdasarkan data dari Bappenas bulan Mei 2020, tercatat baru 25 provinsi yang telah selesai menyusun Rencana Aksi Daerah (RAD) sekaligus menerbitkan peraturan daerah terkait. Provinsi Papua merupakan salah satu provinsi yang tidak dapat menyelesaikan penyusunan Rencana Aksi Daerah (RAD) sesuai dengan kerangka waktu yang ditetapkan pada program SDGs.

Paradigma konstruktivis digunakan pada penelitian ini, dengan pendekatan metode deskriptif kualitatif. Adapun yang menjadi Subjek Penelitian adalah Staf Ahli Tim Pelaksana Program SDGs dari Bappenas, Manager Pilar Ekonomi Sekretariat Nasional SDGs, Staf Bappeda Provinsi Papua, dan Redaktur Pelaksana merdeka.com. Sementara yang menjadi Objek Penelitian adalah Sistem Komunikasi Pemerintah, Aliran Informasi dalam Sistem Komunikasi Pemerintah, serta Hambatan Komunikasi terkait penyusunan RAD di Provinsi Papua. Teknik Pengumpulan Data dilakukan melalui wawancara mendalam, tinjauan pustaka, studi daring, studi pustaka, studi lapangan, dan dokumentasi. Sementara Uji Keabsahan data dilakukan dengan cara triangulasi dan membercheck.

Hasil penelitian menunjukkan (1) Sistem komunikasi pemerintah Provinsi Papua dalam penyusunan RAD adalah menciptakan organisasi yang membentuk lingkungan informasi di antara pilar yang telah ditunjuk dalam penyusunan RAD di Provinsi Papua, (2) Aliran sistem komunikasi pemerintah Provinsi Papua bersifat sentralisasi atau top down. Informasi dari Bappenas selaku penanggungjawab utama menjadi tolak ukur dalam penyusunan RAD, (3) Hambatan komunikasi dalam sistem komunikasi pemerintah Provinsi Papua terkait penyusunan RAD terletak pada hambatan semantik, ketiadaan anggaran, dan kurangnya pemahaman terhadap program SDGs tersebut.

Kata Kunci: Sistem Komunikasi Pemerintah, SDGs, Provinsi Papua
Entre voos e pousos, uma cartografia de/em “Percy Jackson e o Ladrão de Raios”
Authors: Gava Sabrina Da Silva , Scareli Giovana 
Published: July 2021

Num movimento-reflexão, este texto relata a metodologia de pesquisa empregada em uma dissertação de mestrado que estudou a obra “O Ladrão de Raios” a partir de três diferentes produções culturais: o livro, o filme e a graphic novel. Mais que apresentar os resultados de uma pesquisa que, de modo geral, busca observar como os mitos gregos são apropriados pela indústria cultural, este texto trata de apresentar os percursos e intensidades de uma cartografia movimentada por diferentes discursos e imagens – uma linha dentre tantas outras que deseja mostrar a experiência de duas pesquisadoras-cartógrafas na passagem de um pensamento arborescente para um pensamento rizomático utilizando-se de voos, pousos e janelas atencionais.
Rama Subramanian Uraill Paadauruvaakangal
Authors: A Santhi 
Published: July 2021

It is only after the books appeared in the early days and were given verbally for a long time that the history of the origin of the Theocratic Text reveals. Written books were also written in palm leaves in the early days. In such a way, it was written without being dotted, without any distinction between the mark-needle, the one-horn-double horn, and the junction undivided. This led to various confusions in the reading and understanding of it by the following. Everyone began to interpret according to their will. This led to differences in subject symmetry and changes in the structure of the book. There are also differences in the composition of the ancient grammar book, tholkappiyam. The early speakers of tholkappiyam were ilampuranar, Prof. senavaraiyar, Deivachchilaiyar, Nachinarkiniyar, Galladar and palaya uraikarar There are many differences in the text between these contemporaries, and wrote the text for the twentieth-century epic. This article sets out to explore how Rama., Subramaniam differs from them in terms of syllabus and nurpa structure.
Investigações sobre educação em astronomia: estado do conhecimento da RELEA, SNEA, RBEF E CBEF
Authors: Lima Gleici Kelly de , Ghirardello Dante , Santos Machado Daniela , Fortunato de Oliveira Rodolfo , Langhi Rodolfo 
Published: July 2021

Resumo: Este trabalho tem por objetivo analisar e inferir sobre as publicações da área da Educação em Astronomia, entre os anos de 2004 e 2017, a fim de desvelar tendências e saturações de pesquisa. Com base na Análise de Conteúdo, foram examinados 513 artigos e resumos do Simpósio Nacional de Educação em Astronomia, da Revista Latino-Americana de Educação em Astronomia, da Revista Brasileira de Ensino de Física e do Caderno Brasileiro de Ensino de Física. Encontramos como resultados algumas tendências de pesquisa na área de Educação em Astronomia. Dentre elas, o crescimento no número de publicações, a diversidade de objetos de pesquisa, técnicas, metodologias e fundamentações teóricas. Ademais, notamos a ausência de certas informações nos trabalhos analisados que denominamos como “não especificado”, como os referenciais teóricos metodológicos das pesquisas. Partindo-se do pressuposto que a área de Educação em Astronomia ainda tem muito a se desenvolver, ressaltamos a importância deste trabalho, dado que possibilita uma visão geral da progressão da produção acadêmica da área e, consequentemente, aponta direcionamentos para pesquisas futuras.
Palavras-chave: Estado do conhecimento. Educação em Astronomia. Análise de Conteúdo.
Matemática em seções recreativas do periódico O ECO
Authors: Kuhn Malcus Cassiano , Britto Silvio Luiz Martins 
Published: July 2021

Resumo: O artigo tem por objetivo abordar a Matemática em seções recreativas do periódico O Eco, editado pelo Colégio Anchieta, de Porto Alegre, no período de abril de 1914 até o final de 1969. A questão de pesquisa é: quais conhecimentos matemáticos estão presentes nas seções recreativas de O Eco? Como o tema se insere na História da Educação Matemática do Rio Grande do Sul, este estudo qualitativo e documental se ampara na pesquisa histórica. O público-alvo do periódico era a comunidade escolar e a mocidade católica brasileira, apresentando-se conteúdos religiosos, morais e de formação geral. Nos mais de 50 anos de edição do periódico, foram identificadas cinco seções recreativas, com variados períodos de existência: Recreio, Para Pequenos Mathemáticos, Mata Tempo Intelectual, Para o Grande Concurso e Cantinho do Sábio. Nessas seções, foram encontradas perguntas, charadas, problemas, enigmas, curiosidades, palavras cruzadas e outras atividades de passatempo. A Matemática aparece em problemas, perguntas e curiosidades, valorizando o pensamento lógico-matemático dos leitores, premiando assinantes com soluções corretas. Os conhecimentos matemáticos envolvem aritmética, geometria, álgebra, grandezas e medidas, com foco no desenvolvimento de habilidades para cálculo, raciocínio lógico e resolução de problemas, envolvendo situações de forma instigante, provocativa e útil. Assim, os editores do periódico buscavam despertar o interesse e a curiosidade da juventude estudantil, contribuindo para a formação da juventude católica nos colégios onde O Eco circulava.
Palavras-chave: História da Educação. Jesuítas. Revista. Matemática.
Pensamento e raciocínio estocástico na BNCC de educação infantil: inferências para o letramento
Authors: Jahnke Thuanne Souza , Moraes João Carlos Pereira de , Pereira Ana Lúcia 
Published: July 2021

Resumo: Com o presente artigo, visamos analisar possíveis aproximações e potencialidades sobre o trabalho com o pensamento e o raciocínio estocástico, com os objetivos de aprendizagem e desenvolvimento (OAD) presentes na BNCC de Educação Infantil. A pesquisa é de abordagem qualitativa, realizada a partir de uma análise documental. A coleta e a análise de dados se deram a partir dos OAD do referido documento. Nossos resultados apontam que essa aproximação é possível a partir dos 4º e 5º campos de experiência da Base Nacional Comum Curricular para a Educação Infantil, que estão associados aos conteúdos de Combinatória, Estatística e Probabilidade do currículo de Matemática. Como resultados, evidenciamos ainda a importância do desenvolvimento do pensamento estocástico nas crianças pequenas para que compreendam o mundo a sua volta e saibam organizar informações por meio de tabelas, gráficos e outras formas de registros. Como potencialidades, destacamos que os OAD presentes na BNCC apresentam-se como fortes possibilidades didático-metodológicas para a construção do Letramento Estocástico.
Palavras-chave: Letramento Estocástico. BNCC. Educação Infantil.
O letramento científico como prática no itinerário formativo de um bolsista de iniciação à docência
Authors: Oliveira-Junior Nestor Barbosa de , Lopes David Santana 
Published: July 2021

Resumo: Orientando-se pelos princípios do Letramento Científico, o presente estudo irá narrar os enlaces formativos de um professor em formação, participante do Programa Institucional de Bolsas de Iniciação à Docência (PIBID), a partir de intervenções didáticas desenvolvidas em uma escola pública da cidade Salvador (Bahia) entre julho de 2018 e agosto de 2019. Essas experiências conduzirão a escrita deste estudo, apresentando como método de análise os princípios das Narrativas Autobiográficas obtidas em cada intervenção didática realizada, além das conquistas e obstáculos que despontaram durante essa trajetória debutante como professor-pesquisador. As etapas essenciais que compõem o método são: a) descrição do contexto acerca do itinerário formativo; b) realização de um balanço de aprendizagens; c) definição da narrativa; d) interpretação sobre as experiências vivenciadas e; e) complementos de significação. As narrativas discutem sobre os desafios e reflexões ao incorporar em sua prática docente perspectivas para um Ensino de Ciências que se opõe a modelos mecânicos e transmissivos. Os pressupostos teóricos do Letramento Científico possibilitaram ao ex-bolsista, durante seu itinerário formativo, uma visão expandida da função social da atividade científica. Tais experiências podem contribuir para discussões acerca do perfil de professores que se pretende construir nos cursos de Licenciatura e nos programas de Formação Inicial.
Palavras-chave: Letramento Científico. PIBID. Itinerários Formativos.
The Analysis of Figurative Language in Coldplay’s Parachutes Album
Authors: Astuti Amelia Yuli , Astuti Widia 
Published: July 2021

Figurative language is language that uses various kinds of figures. Figurative language is a form of using language in the form of a comparison or parable. This research analyze figurative language in Coldplay's song lyrics. The data source is taken from all song lyrics of Parachutes album by Coldplay. The purposes of this research are: (1) to describe the types of figurative language found in Coldplay song lyrics, (2) to explain the meaning of figurative language contained in the selected song lyrics, and (3) to find out the types of figurative language is dominantly used in Coldplay song lyrics. This research uses qualitative descriptive method.
The data analysis of this research is to follow the following steps: selecting songs that contain figurative language, identifying types of figurative language by reading carefully, classifying types of figurative language from the data, and making conclusions. The results of this research show that the total number of figurative languages used in the lyrics of the song parachutes Coldplay is 35 types of figurative language. Which consists of: 2 simile, 3 repetition, 9 metaphor, 8 hyperbole, and 13 rhetoric. The type of figurative language most dominantly is rhetoric.