bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germinación y crecimiento de Leonia glycycarpa en Arosemena Tola, Napo, Ecuador
Authors: Abril-Saltos Ricardo Vinicio , Villarroel-Gancino Carolina Yasmin , Ramos-Criollo Diego Mauricio , Pillco-Herrera Briyiidt Maryeli , Quishpe-López Jonny David , López-Adriano Katherine Pamela 
Published: November 2021

Introducción. La pérdida de especies de plantas silvestres genera la necesidad de evaluar sus características de germinación y crecimiento en diferentes ambientes en la región amazónica. Objetivo. Evaluar la germinación ex situ y el crecimiento de Leonia glycycarpa en condiciones de uso de suelo de bosque primario y cobertura de zonas intervenidas en el Centro de Investigación, Postgrados y Conservación Amazónica en Arosemena Tola, Napo, Ecuador. Materiales y métodos. El estudio se desarrolló en dos fases entre 2018-2020, la primera, de germinación ex situ en invernadero, donde se registraron días hasta la emergencia y crecimiento en bandeja, y la segunda de crecimiento posterior al trasplante en campo, en uso de suelo de bosque primario y cobertura de zona intervenida (arbolado de Inga sp. y arbolado de melatomatacea). Se registró la altura de la planta, diámetro del tallo y número de hojas hasta los 360 días y variables ambientales como temperaturas del aire y suelo, luminosidad y nutrientes del suelo. Se establecieron curvas de crecimiento para la altura de la planta y diámetro del tallo. Se realizó una correlación entre las medidas de crecimiento y las variables ambientales y edáficas. Resultados. En la primera fase se obtuvo una media de 33,5 días a la emergencia con un 76 % de plantas emergidas a los 45 días, con una media de 10,7cm en altura y 3,02 mm en diámetro. En el crecimiento en campo, las plantas ubicadas en la zona intervenida, alcanzaron mayor desarrollo y prevalecieron los modelos lineal y cuadrático en la altura de la planta y lineal en el diámetro del tallo. Se hallaron correlaciones significativas del contenido de nutrientes y la temperatura con las variables del crecimiento. Conclusión. L. glycycarpa se pudo propagar en condiciones de invernadero. Los factores ambientales y edáficos, influyeron en el crecimiento en altura, diámetro y número de hojas, con mayor crecimiento en la cobertura de suelo en la zona intervenida.
Novel Hybrid SETMOS Logic for Ultra-low-power Applications
Authors: Shah Raj Sanjivkumar , Parekh Rutu , Dhavse Rasika 
Published: November 2021

Abstract
This paper investigates the Single-GateSingle Electron Transistors (SG-SETs) based hybrid SETMOS logic circuits for ultra-low-power applications at room temperature. The methodological design of the proposed hybrid SETMOS logic circuits is compatible with 22- nm CMOS bias and process. The widely acclaimed Mahapatra-IonescuBannerjee (MIB) model is modified to implement the proposed SG-SET and hybrid SETMOS logic circuits using Verilog-A. Logic inverter, two-input NAND, NOR, AND, OR, EX-OR, and EX-NOR logic gates are simulated at room temperature using novel SETMOS hybridization. The proposed work is compared with the 22-nm CMOS counterpart (simulated with the same setup). We found that the reduction in total power dissipation by 98.04%, 96.45%, 94.65%, 93.7%, 92.63%, 93.52%, 95.57% using hybrid SETMOS NAND, NOR, AND, EX-OR and EXOR gates than 22 nm CMOS logic gates. The proposed work is compared with other works of literature. We also examined the robustness of the proposed logic circuits against temperature variations from 77 K to 500 K.
A Single-institution Study of So-called “non-secreting” Intracranial Germinomas: Neurological Characteristics, Treatment Procedures, and Clinical Outcomes
Authors: Zhou Jiajun , Lei Ting , Zuo Jinyi , Wu Chenxing , Liu Rui , Li Shouwei 
Published: November 2021

Abstract
Background and ObjectiveIntracranial germinomas are rare brain tumors. In the present study, we collected data of patients with histology-proven germinomas, and analyzed their neurological characteristics, treatment procedures, and clinical outcomes.MethodsWe reviewed the data of patients with “non-secreting” intracranial germinomas, and analyzed the neurological characteristics, treatment procedures, and clinical outcomes.ResultsThere were 162 (69.8%) male patients and 70 (30.2%) female patients. Pineal germinomas were mainly found in male patients (98.3%), and germinomas in sellar/suprasellar region were often observed in female patients (67.5%). The most common clinical presentations were polyuria/polydipsia (42.7%), headache (40.5%), visual disturbance (37.5%), and motor impairment (28.4%). Patients in the pure germinoma group had a higher serum beta-human chorionic gonadotropin (β-HCG) level than in the germinoma plus syncytiotrophoblastic giant cells (STGCs) group (P=0.001), and no significant difference was noted in serum alpha-fetoprotein (AFP) level between the two groups (P=0.540). Bifocal or multifocal tumors had a higher tendency to intracranial dissemination and spinal seeding (P<0.001 and P<0.001, respectively). The mean duration of open craniotomy was 268.8 min with an average volume of blood loss of 316.9 mL, compared with 27.0 min and 6.2 mL in cases who received stereotactic biopsy (P<0.001 and P<0.001). The most common complication in both groups was postoperative hemorrhage (7.0% and 8.5%). Patients who received biopsy had higher KPS scores after surgery and at hospital discharge than on admission in contrast to open craniotomy (P<0.001 and P=0.047, respectively). Deterioration of KPS at hospital discharge than on admission was observed in 4, 7, 18, and 1 cases who received partial resection, subtotal resection, gross total resection, and biopsy (P<0.001).ConclusionsBifocal and multifocal germinomas have a higher tendency of dissemination, and additional attention should be paid to the imaging findings. Patients may not necessarily benefit from the surgical resection because of the surgical trauma and the postoperative complications, and stereotactic biopsy is highly significant in clinical practice.
Certificateless Network Coding Scheme from Certificateless Public Auditing Protocol
Authors: Bian Genqing , Song Mingxuan , Shao Bilin 
Published: November 2021

Abstract
In recent years, network coding has received extensive attention and been applied to various computer network systems, since it has been mathematically proven to enhance the network robustness and maximize the network throughput. However, it is well-known that it is extremely vulnerable under pollution attacks. Certificatelss network coding scheme (CLNS) is a recently-proposed mechanism to defend against pollution attacks for network coding, which avoids the tedious management of certificates and the key-escrow attack. Until now, only a few constructions were presented and more ones should be given in order to enrich this field. In this paper, for the first time, we study the general construction of CLNS from certificateless public auditing protocol (CL-PAP), although the two areas seem to be quite different in their nature and are studied independently. Since there are many candidates of CL-PAPs, we naturally obtain abundant constructions of CLNSs according to our systematic way. In addition, in order to show the power of our general construction, we also present a concrete implementation given a specific CL-PAP. The performance analysis and experimental result show that the implemented CLNS is competitive in the existing network coding schemes.
Hunting the Hidden: Surgical Treatment of Chronic Silent Thrombus in the Left Ventricle. A Case Report.
Authors: He Fengpu , Jiao Yiping , Jiang Lijun 
Published: November 2021

Abstract
Background: Silent left ventricular thrombus is dangerous. The current standard anticoagulation therapy is not effective, and the outcomes are frustrated.Case presentation: A 33-year-old man with silent left ventricular thrombus, which was detected incidentally by transthoracic echocardiography. After admission, anticoagulation with low-molecular-weight heparin therapy was carried out. Unfortunately, acute left temporal embolism emerged 5 days later, then the patient was transferred to the neurology department for further treatment. One month later, the patient received coronary artery bypass grafting (CABG), ventricular aneurysm resection and left ventricular thrombectomy and was discharged uneventfully after surgery.Conclusions: For the patients with giant or hypermobile left ventricular thrombus or recurrent systemic emboli, surgical treatment should be a priority.
Schwannoma of Left Chest Wall: a Case Report and Literature Review
Authors: Li Congcong , Tang Ze , Qin Da , Lu Tianyu , Yang Yue , Cui Youbin 
Published: November 2021

Abstract
Background: Schwannoma of chest wall is rare intercostal nerve tumor originated from Schwann cells. Here, we present a rare case about schwannoma was misdiagnosed as solitary fibroma by preoperative biopsy. We intend to improve clinicians' understanding of the disease by discussing the clinical manifestations, diagnostic points and differential diagnosis of patients with thoracic wall schwannoma.Case presentation: A 38-year-old male presented with "left chest pain for more than 1 month". Enhanced Computer Tomography(CT) can of the lung revealed space occupying lesions in the left lower posterior chest wall. Preoperative biopsy was solitary fibroma. After the improvement of preoperative preparation, the patients were given surgical treatment, postoperative pathology showed: schwannoma of chest wall. Chest pain improved after operation. The patients were followed up for 8 months.Discussion and Conclusions: Schwannoma, especially in the chest wall, is rare, with atypical clinical symptoms, single imaging manifestations, high variable rate of puncture pathology, and easy to be misdiagnosed. Complete surgical resection of tumor is the main treatment, and no new adjuvant / adjuvant therapy has been reported yet.
Risk Factor Analysis and Nomogram for Predicting In-Hospital Mortality in Patients with Sepsis and Lung Infection
Authors: Ren Yinlong , Zhang Luming , Xu Fengshuo , Han Didi , Zheng Shuai , Zhang Feng , Li Longzhu , Wang Zichen , Lyu Jun , Yin Haiyan 
Published: November 2021

Abstract
BackgroundLung infection is a common cause of sepsis, and patients with sepsis and lung infection are more ill and have a higher mortality rate than sepsis patients without lung infection. We constructed a nomogram prediction model to accurately evaluate the prognosis of and provide treatment advice for patients with sepsis and lung infection.MethodsData were retrospectively extracted from the Medical Information Mart for Intensive Care (MIMIC-III) open-source clinical database. The definition of Sepsis 3.0[10] was used, which includes patients with life-threatening organ dysfunction caused by an uncontrolled host response to infection, and SOFA score ≥2.The nomogram prediction model was constructed from the training set using logistic regression analysis, and was then internally validated and underwent sensitivity analysis.ResultsThe risk factors of age, lactate, temperature, oxygenation index, BUN, lactate, Glasgow Coma Score(GCS), liver disease, cancer, organ transplantation, Troponin T(TnT), neutrophil-to-lymphocyte ratio(NLR), and CRRT, MV, and vasopressor use were included in the nomogram. Compared with the Sequential Organ Failure Assessment (SOFA) score and Simplified Acute Physiology Score II (SAPSII), the nomogram had better discrimination ability, with areas under the receiver operating characteristic curve (AUROC) of 0.743 (95% confidence interval [95% CI]=0.713–0.773, p < 0.001) and 0.746 (95% CI=0.699–0.790, p < 0.001) in the training and validation sets, respectively. The calibration plot indicated that the nomogram was adequate for predicting the in-hospital mortality risk in both sets. The decision-curve analysis(DCA) of the nomogram revealed that it provided net benefits for clinical use over using the SOFA score and SAPSII in both sets. ConclusionOur new nomogram is a convenient tool for accurate predictions of in-hospital mortality among patients with sepsis and lung infection. Treatment strategies that improve the factors considered relevant in the model could increase in-hospital survival for these ICU patients.
Convolutional Neural Networks For Apical Lesion Segmentation From Panoramic Radiographs
Authors: Song Il-Seok , Shin Hak-Kyun , Kang Ju-Hee , Kim Jo-Eun , Huh Kyung-Hoe , Yi Won-Jin , Lee Sam-Sun , Heo Min-Suk 
Published: November 2021

Abstract
Convolutional neural networks (CNNs) have rapidly emerged as one of the most promising next-generation artificial intelligence (AI) in the field of medical and dental researches, which can further provide an effective diagnostic methodology allowing for detection of diseases at early age. This study was, thus, aimed to evaluate performances for apical lesion segmentation from panoramic radiographs using two CNN algorithms including U-Net and FPN. A total of 1000 panoramic radiographs showing apical lesions were separated into training (n = 800, 80%), validation (n = 100, 10%), and test (n = 100, 10%) dataset, respectively. These datasets were further incorporated to construct CNN models using two algorithms, respectively. The performances of identifying apical lesions were evaluated after calculating precision, recall, and F1-score from both CNN models. Both U-Net and FPN algorithms provided considerably good performances in identifying apical lesions in panoramic radiographs.
Inhibitory Effects of Doxycycline on Tumor Progression In vitro and on Metastases in Early-Stage Osteosarcoma Xenografts Mice.
Authors: Hadjimichael Argyris Costas , Foukas Athanasios F. , Papadimitriou Evangelia , Peristiani Chrysostomi , Chaniotakis Ioannis , Pergaris Alexandros , Theocharis Stamatios , Sarantis Panagiotis , Psyrri Amanda , Mavrogenis Andreas F. , Savvidou Olga D , Kaspiris Angelos , Papagelopoulos Panayiotis J. , Armakolas Athanasios 
Published: November 2021

Abstract
BackgroundOsteosarcoma (OS) is the commonest primary osseous malignant tumor with a high propensity to metastasize in lungs. Pulmonary widespread micrometastatic lesions are present in up to 80% of patients at initial diagnosis and they are associated with significantly worse prognosis. Doxycycline (Dox) is a synthetic tetracycline that has been shown to have anti-cancer properties in vitro and in vivo, and inhibit angiogenesis, effects that may prove beneficial for several types of cancer. The aim of the present work was to study how Dox affects OS cells’ growth in vitro and in vivo and OS-driven pulmonary metastasis in vivo. Methods In vitro, the effect of Dox was measured in MG-63 and 143B human OS cells’ viability, apoptosis, and migration. In vivo, highly metastatic143B cells were orthotopically implanted into the tibia of SCID mice and tumor growth as well as pulmonary metastases between Dox treated and untreated, non-amputated and early amputated xenografts were examined. ResultsDox decreased the viability, inhibited the migration, and induced the apoptosis of OS cells in vitro. In vivo, Dox significantly enhanced tumor necrosis at primary OS sites, similarly to its in vitro effect. It also decreased the expression of Ki67, metalloproteinases 2 and 9 (MMP2 and MMP9), vascular endothelial growth factor A (VEGFA) and Ezrin in primary tumors. It also decreased the circulating VEGFA and MMP9 protein levels, in line with the decreased metastatic burden in Dox-treated mice in both non-amputated and early amputated xenografts.ConclusionsOur results suggest that adjuvant administration of Dox may decrease OS growth and development of pulmonary metastases. Administration of Dox in combination with surgical resection and standard chemotherapeutic protocols in the early-stages of OS treatment is also supported. Moreover, Dox administration prior to the development of clinically detectable pulmonary macrometastases, is associated with enhanced clinically benefits from its anti-metastatic effect.
Melanoma Stem Cell Vaccine Modified with IL-33 Induces Anti-Tumor Immunity by Activating CD8+T Cells
Authors: Yin Qiliang , Zhao Na , Chang Ying , Dong Mingxin , Xu Meng , Xu Wenyue , Jin Hao-fan , Liu Wensen , Xu Na 
Published: November 2021

Abstract
Background: Melanoma stem cells (MSCs)-based vaccine strategies have been a potent immunotherapeutic approach for melanoma treatment, which aimed at inducing specific anti-tumor immunity and targeting cancer stem-like cells. To boost anti-melanoma activity induced by B16F10 CD44+CD133+ MSCs (B16F10 MSCs) vaccine, we generated a novel vaccine expressing IL-33. Tumor growth and pulmonary metastasis were assessed to estimate the effectiveness of the vaccine. Methods: The antitumor effect of the vaccine was observed in this study. The mechanism of inducing anti-tumor immunity was detected by flow cytometric assays, cytotoxicity assays, and ELISA, including expression of CD8+T cells surface and intracellular molecules, the cytotoxic activity of splenocytes in the immunized mice and secretion of serum cytokines.Results: We found that MSCs vaccine expressing IL-33 significantly inhibited melanoma growth and reduced the lung melanoma nodules. Mechanistic investigations established that the vaccine-primed CD8+T cells could selectively target MSCs and confer anti-tumor immunity, which included promoting the proliferation of CD8+T cells, inhibiting the differentiated depletion of CD8+T cells in vivo, inducing the formation of memory CD8+T cells, and activating specific cytotoxic T lymphocyte (CTL) immune response. Conclusions: MSCs vaccine expressing IL-33 is able to initiate anti-tumor specific immune response by activating CD8+T cells.
Composite Anti-Disturbance Control for Ship Dynamic Positioning Systems with Thruster Faults
Authors: Yu Ziwen , Wei Xinjiang , Zhang Huifeng , Hu Xin , Han Jian 
Published: November 2021

Abstract
Anti-disturbance control problem is studied for ship dynamic positioning systems with disturbances and thruster faults. The disturbances include slowly-varying environmental disturbances and norm bounded disturbances. For the slowly-varying environmental disturbance, a stochastic disturbance observer is established to give the online estimation. For thruster faults, a fault diagnosis observer is designed. Then, a composite anti-disturbance control (CADC) strategy is raised, which ensures asymptotic mean-square boundedness of the closed-loop system. Finally, the simulation example proves the validity of the controller.
Salvage Robot-assisted Radical Prostatectomy Following Focal Ablation With Irreversible Electroporation: Feasibility, Oncological and Functional Outcomes
Authors: Blazevski Alexandar , Gondoputro William , Scheltema Matthijs J. , Amin Amer , Geboers Bart , Barreto Daniela , Haynes Anne-Maree , Shnier Ron , Delprado Warwick , Agrawal Shikha , Thompson James Edward , Stricker Phillip 
Published: November 2021

Abstract
BackgroundTo report the feasibility, oncological and functional outcomes of salvage robot-assisted radical prostatectomy (sRARP) for recurrent prostate cancer (PCa) after irreversible electroporation (IRE).MethodsThis was a retrospective analysis of patients who underwent sRARP after IRE treatment in our institution. Surgical complications, oncological and functional outcomes were assessed.Results15 patients with at least 12 months follow up were identified out of the 234 men who underwent primary IRE between 2013 and 2019. The median [IQR] age was 68 (62 – 70) years. The median [IQR] time from focal IRE to sRARP was 42 (21 – 57) months. There were no rectal, bladder or ureteric injuries. The T-stage was pT2 in 9 (60%) patients and pT3a in 6 (40%) patients. Only one (7%) patient had a positive surgical margin. At a median [IQR] follow up of 22 (16 – 32) months no patient had a biochemical recurrence (PSA >0.2). All 15 patients were continent (pad-free) by 6 months and 9 (60%) patients had erections sufficient for intercourse with or without PDE5 inhibitors. No predisposing factors were identified for predicting erectile dysfunction after sRARP. ConclusionsIn patients with recurrent or residual significant PCa after focal IRE ablation it is feasible to obtain good functional and oncological outcomes with sRARP. Our results demonstrate that good outcomes can be achieved with sRARP, when respecting close monitoring post-IRE, good patient selection and surgical experience.
Interaction Between Diet and Dominant Fecal Microbiota Along the First Year of Life
Authors: Gómez-Martín María , Saturio Silvia , Arboleya Silvia , Herrero-Morín David , Calzón Margot , López Teresa , González Sonia , Gueimonde Miguel 
Published: November 2021

Abstract
Extensive work has established the importance of the gut microbiota during the first years of life. However, there are few longitudinal studies describing the role of infants´ diet on the evolution of the fecal microbiota and their metabolic activity during this stage. The aim of this work was to explore the impact of diet on the composition of the major intestinal microorganisms and their main microbial metabolites from birth to 12 months. This is a longitudinal prospective study analyzing fecal microbiota, bacterial groups levels were determined by qPCR and short-chain fatty acids (SCFAs) levels by gas chromatography, as well as information from self-administered questionnaires about general characteristics and food frequency from a cohort of 83, Spanish and full-term, infants at 15, 90, 180 and 365 days of age. Results revealed that Enterobacteriaceae and Bifidobacterium decrease in weaning period contrary to Bacteroides group and Clostridium cluster IV. Furthermore, a clustering based on fecal bacterial groups, SCFAs and type of delivery and feeding, gender and living area suggested that the excretion of SCFAs is strongly related to the type of lactation. Conclusion: our study supports weaning period as a key step for gut microbiota transition and suggests the importance of the consumption of dietary fiber with the increase of certain bacterial groups as Clostridium cluster IV, which could be beneficial for the host. Finally, studies specially designed to analyze the production and the excretion of SCFAs in children are needed to understand how diet could influence in this process.
LICAP Versus TDAP for Reconstruction of Partial Breast Defects
Authors: Hashem Tarek , Taha Sherif N , Oraby Ahmed 
Published: November 2021

Abstract
BackgroundPerforator flaps are the latest development in reconstructive surgery. Pedicled chest wall perforator flaps can be utilized in many cases of partial breast reconstruction. This research compares the outcome and technique of Thoracodorsal Artery Perforator Flap (TDAP) and the Lateral Intercostal Artery Perforator Flap (LICAP) in reconstruction of partial breast defects.MethodsPatient records were reviewed for the time period between 2011-2019 at the breast unit of the National Cancer Institute of Cairo University. Eighty three patients were accessible for the study. (46 cases of TDAP flap and 37 cases of LICAP flap). Relevant clinical data were extracted from patients’ records. A special visit was organized for all 83 patients ,where a digital photograph was taken in an antro-posterior view. The photographs were later processed via BCCT.core software to obtain an objective cosmetic outcome assessment.ResultsComplication rates and cosmetic outcome were comparable for both techniques. TDAP flap flap proved to require more tedious dissection and preoperative Doppler mapping to localize perforator vessels. On the other hand LICAP was technically easier with more consistent perforators.ConclusionPedicled chest wall perforator flaps constitute an excellent reconstructive option in partial breast defects. They have replaced musculocutaneous flaps to a large extent.