bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional versus mirror three-dimensional printing technology for isolated acetabular fractures: a retrospective study with a median follow-up of 25 months
Authors: Xiao Kai , Xu Bo , Ding Lin , Yu Weiguang , Bao Lei , Zhang Xinchao , Chen Meiji , Liu Xiangzhen , Lin Huanyi , Li Tengfei 
Published: June 2021

Objective To assess the outcomes of traditional three-dimensional (3D) printing technology (TPT) versus mirror 3D printing technology (MTT) in treating isolated acetabular fractures (IAFs). Methods Consecutive patients with an IAF treated by either TPT or MTT at our tertiary medical centre from 2012 to 2018 were retrospectively reviewed. Follow-up was performed 1, 3, 6, and 12 months postoperatively and annually thereafter. The primary outcome was the Harris hip score (HHS), and the secondary outcomes were major intraoperative variables and key orthopaedic complications. Results One hundred fourteen eligible patients (114 hips) with an IAF (TPT, n = 56; MTT, n = 58) were evaluated. The median follow-up was 25 months (range, 21–28 months). At the last follow-up, the mean HHS was 82.46 ±14.70 for TPT and 86.30 ± 13.26 for MTT with a statistically significant difference. Significant differences were also detected in the major intraoperative variables (operation time, intraoperative blood loss, number of fluoroscopic screenings, and anatomical reduction number) and the major orthopaedic complications (loosening, implant failure, and heterotopic ossification). Conclusion Compared with TPT, MTT tends to produce accurate IAF reduction and may result in better intraoperative variables and a lower rate of major orthopaedic complications.
Multipurpose Bracket Positioning Tool: A Modified Probe for Accurate Bracket Placement
Authors: Shenoi Susmita Bala , Deshpande Sumedh , Hattarki Rohan S. 
Published: June 2021

There is no single bracket gauge that can be used universally for all teeth to orient brackets in the vertical and axial planes simultaneously. To overcome the increased armamentarium and steps involved in accurately positioning brackets, we have modified a UNC-15 probe to fabricate a multipurpose bracket positioning tool (MBP tool). Thus, one single instrument can be used not only to position brackets (both anterior and posterior) in all planes but also for the quick verification of positioned brackets just before curing.
Foreign Direct Investment and Growth Nexus: Further Evidence from Africa’s Largest Economy
Authors: Orji Anthony , Nwagu Godson Umunna , Ogbuabor Jonathan E. , Anthony-Orji Onyinye I. 
Published: June 2021

The study investigated the effect of foreign direct investment (FDI) on economic growth in Nigeria, which is currently Africa’s largest economy, and also determined the long-run relationship between FDI and economic growth in Nigeria from 1981 to 2017. The study adopted the autoregressive distributed lag modelling approach and ordinary least square in the analysis. The empirical results revealed that FDI has a positive and significant relationship with economic growth in Nigeria within the period under review. The study concluded and recommended that Nigerian Government should formulate policies that will attract more FDI in all sectors of the economy especially in the service and manufacturing sectors, so as to improve the infrastructural facilities and production of goods in the country and also expand its labour force. Finally, there is need to improve the educational policy of the country in order to raise the stock of human capital in the country that will make useful policies for the attraction for productive FDIs in the country. JEL Classification: E22, F21, F23, F43
Regional characteristics of the gender employment gap: A spatio-temporal approach
Authors: Chica-Olmo Jorge , Checa-Olivas Marina , Lopez-Castellano Fernando 
Published: June 2021

There is a substantial body of research that recognises the importance of analysing regional characteristics in employment and labour relations that occur in a given geographical context. However, this phenomenon has been scarcely studied from a spatial approach. This article uses a spatio-temporal panel data model to examine the spatial interactions between the gender employment gap and, some labour and socioeconomic characteristics of 727 municipalities of Andalusia, Spain, for the period 2012–2016. The results show that due to spatial diffusion mechanisms, a spatial spillover effect occurs in both the gender gap in employment and in some of the labour and socioeconomic characteristics considered. These findings may be extended to other geographic areas and can be of use for the implementation of regional policies aimed at narrowing the gender employment gap.JEL Codes: R10, J16, E24
Care Barriers for Patients With Nonsyndromic Orofacial Clefts in Saudi Arabia: A Cross-Sectional Study
Authors: Allaf Hanaa , Helal Narmin , Basri Osama , AlShadwi Ahmad , Sabbagh Heba 
Published: June 2021

Objective: To evaluate the barriers faced by patients with nonsyndromic orofacial clefts (NSOFC) throughout their treatment course in Saudi Arabia. Design: A cross-sectional study. Setting: Eleven different governmental health care centers across Saudi Arabia. Patients: Records of pediatric patients with NSOFC. Interventions: A questionnaire with multiple validation stages was designed to assess the barriers in care of these patients through telephonic interviews with the parents or guardians of patients with NSOFC. Main Outcome Measures: We identified 3 care-barrier–related factors: (1) geographic accessibility, (2) appointment availability and accessibility, and (3) scheduling-related barriers. Results: Overall, 240 participants of both sexes, with orofacial cleft of various types and with various demographic characteristics (residence, family monthly income, and caregiver level of education) were included. The highest mean score of care barriers was reported for scheduling-related barriers. Overall, 186 individuals reported sometimes/often not receiving the required medical care for the following reasons: scheduling difficulties (89%; 37.1%), prolonged waiting room time (40%; 16.7%), and transportation difficulties (36%; 15.0%). A linear regression showed that parents cited late appointments as the main reason for patients with NSOFC not receiving adequate medical care. Care-barrier factors were significantly related to gender ( P = .035), patient age ( P < .001), place of residency ( P < .001), and caregiver’s level of education ( P = .015). Conclusions: Gaps in the health care system directly related to common care barriers need to be addressed to ensure adequate care for patients with NSOFC.
Expanding Understanding of Racial-Ethnic Differences in ADHD Prevalence Rates among Children to Include Asians and Alaskan Natives/American Indians
Authors: Wong Ashlyn W. W. A. , Landes Scott D. 
Published: June 2021

Background Prior studies show that ADHD prevalence rates vary by race-ethnicity, but these studies do not include a full range of racial-ethnic minority groups. Objective This study aimed to understand differences in ADHD prevalence among children across a wider range of racial-ethnic groups, overall and stratified by biological sex. Method Data on children aged 5 to 17 from the 2004 to 2018 National Health Interview Survey Sample Child Files were used in analyses ( N = 120,129). Results Compared to Non-Hispanic White children, ADHD prevalence was lower among Hispanic and Non-Hispanic Asian children. This difference was present for both males and females. Across all racial-ethnic groups, males had higher ADHD prevalence than females. Conclusion Results from this study provide further evidence that racial-ethnic disparities in ADHD prevalence rates persist across sex and provide initial evidence of substantially lower ADHD prevalence among Non-Hispanic Asians. Implications, limitations, and future research directions derived from the results are discussed.
Emancipatory struggles and their political organisation: How political parties and social movements respond to changing notions of emancipation
Authors: Butzlaff Felix 
Published: June 2021

In this article, I address the ways in which debates in liberal, (post)Marxist and postmodernist social theory have remoulded readings of emancipation – and how these reformulations have affected the organisation of emancipatory struggles by and in political parties and social movements. I focus on three conceptual ambiguities that have spurred theoretical disputes and restructured organisational imaginations of emancipation: who might struggle for liberation, to what end and in which ways. In all three respects, understandings of emancipation have become increasingly individualised, contingent and process-oriented – both in theory and in its political-organisational correspondents. As a consequence, effective collective struggles for autonomy may become ever more difficult to organise. While occurring in the name of further liberation, the ongoing reinterpretation of emancipation and its impact on the political organisation of emancipatory struggles might in the end hamper or even undermine the very liberation and autonomy they had aimed to promote.
Back-Table Modified Stent-Graft for Endovascular Repair of Ascending Aorta
Authors: Shi Juan , Liu Ligang , Wei Xiang , Ma Mingjia 
Published: June 2021

Objectives To investigate the effectiveness of modified stent-grafts (SGs) for the management of ascending aortic pathologies. Materials and Methods From January 2015 to December 2019, 31 individuals were treated by ascending aortic endovascular repair with a back-table modified SG for acute (n=4) or chronic (n=1) type A aortic dissections, penetrating aortic ulcers (n=18), pseudoaneurysms (n=2), anastomotic fistula (n=1), and endoleaks after thoracic endovascular aortic repair (TEVAR) (n=5). The commercially available thoracic aortic SGs were modified with a fenestration or truncation technique on the back-table according to aortography during the operation. Results The 30-day mortality and aorta-related mortality rates were 12.9% and 6.5%, respectively. There were 2 strokes, 3 respiratory insufficiencies, and 6 endoleaks during hospitalization. During a mean follow-up of 28.8±16.6 months, the overall survival rates at 1 year and 3 years were both 80.6%. Free from adverse event rates at 1 year and 3 years were 88.9% and 84.7%, respectively. There were 2 deaths during follow-up: One patient died of cachexia 1 month after discharge, and the other patient died of acute myocardial infarction 3 months after discharge. One patient with a pseudoaneurysm underwent open ascending aorta replacement 3 months after discharge for a type Ia endoleak. Another patient suffered from cerebellar infarction 17 months after discharge. Conclusion The modified SG for endovascular repair of the ascending aorta is a practicable alternative and presents acceptable outcomes in high-risk patients.
Predictive Value of a Prognostic Model Based on Lymphocyte-to-Monocyte Ratio Before Radioiodine Therapy for Recurrence of Papillary Thyroid Carcinoma
Authors: Zhou Chunyan , Duan Dong , Liu Shuang 
Published: June 2021

Background: The aim of this study was to investigate the predictive value of a prognostic model based on the lymphocyte-to-monocyte ratio (LMR) before radioiodine treatment for the recurrence of papillary thyroid carcinoma (PTC). Methods: Clinicopathological data of 441 patients with papillary thyroid cancer were collected retrospectively. The Receiver operating characteristic (ROC) was used to determine the optimal cut-off value for predicting PTC recurrence by LMR before radioiodine treatment. Recurrence was the endpoint of the study, and survival was estimated by the Kaplan-Meier method, and any differences in survival were evaluated with a stratified log-rank test. Univariate and multifactorial analyses were performed using Cox proportional-hazards models to identify risk factors associated with PTC recurrence. Results: The ROC curve showed that the best cut-off value of LMR before radioiodine treatment to predict recurrence in patients with PTC was 6.61, with a sensitivity of 54.1%, a specificity of 73%, and an area under the curve of 0.628. The recurrence rate was significantly higher in the low LMR group (16%) than in the high LMR group (5%) ( P = 0.001, χ2 = 12.005). Multifactorial analysis showed that LMR < 6.61 ( P = 0.006; HR = 2.508) and risk stratification (high risk) ( P = 0.000; HR = 5.076) before radioiodine treatment were independent risk factors predicting recurrence in patients with PTC. Patients with preoperative LMR < 6.61 and high risk stratification had the lowest recurrence-free survival rate and the shortest recurrence-free survival time. Conclusions: The LMR-based prognostic model before radioactive iodine treatment is valuable for early prediction of PTC recurrence and it can be used in clinical practice as a supplement to risk stratification and applied in combination to help screen out patients with poorer prognosis early.
What is the median volume of intracerebral hemorrhage and is it changing?
Authors: Robinson David , Van Sanford Carson , Kwon Soo Young , Coleman Elisheva , Sekar Padmini , Murphy Ryan , Flaherty Matthew L , Demel Stacie L , Aziz Yasmin , Moomaw Charles J , Haverbusch Mary , Khoury Jane , Adeoye Opeolu , Walsh Kyle B , Broderick Joseph P , Woo Daniel 
Published: June 2021

Objectives Population-level estimates of the median intracerebral hemorrhage (ICH) volume would allow for the evaluation of clinical trial external validity and determination of temporal trends. We previously reported the median ICH volume in 1988. However, differences in risk factor management, neuroimaging, and demographics may have affected ICH volumes. The goal of this study is to determine the median volume of ICH within a population-based cross-sectional study, including whether it has changed over time. Methods The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was a population-based study of ICH among residents of the Greater Cincinnati/Northern Kentucky region from 2008 through 2012. This study utilizes those data and compares with ICH cases from the same region in 1988. Initial computed tomography images of the head were reviewed, and ICH volumes were calculated using consistent methodology. Results From 2008 through 2012, we identified 1117 cases of ICH. The median volume of ICH was 14.0 mL and was lower in black (11.6) than in white (15.5) patients. Median volumes of lobar and deep ICH were 28.8 mL and 9.8 mL, respectively. Median ICH volume changed significantly from 1988 to 2008–2012, with age-and-race-adjusted volume decreasing from 18.3 mL to 13.76 mL (p = 0.025). Conclusions Median volume of ICH was 13.76 mL, and this should be considered in clinical trial design. Median ICH volume has apparently decreased from 1988 to 2008–2012.
A propensity-matched comparison of long-term disability worsening in patients with multiple sclerosis treated with dimethyl fumarate or fingolimod
Authors: Salter Amber , Lancia Samantha , Cutter Gary , Marrie Ruth Ann , Mendoza Jason P. , Lewin James B. , Fox Robert J. 
Published: June 2021

Background: Although the aggregate of data among patients with multiple sclerosis (MS) have shown similar efficacy between dimethyl fumarate (DMF) and fingolimod (FTY), most studies have not assessed long-term worsening of disability. We compared long-term disability worsening over 5 years, as assessed by the Patient-Determined Disease Steps (PDDS), among participants with MS treated with DMF or FTY. Methods: We identified individuals in the North American Research Committee on Multiple Sclerosis (NARCOMS) registry who had relapsing-remitting MS (RRMS), residing in the United States (Spring 2011 to Spring 2018), who initiated treatment with DMF ( n = 689) or FTY ( n = 565) and had ⩾1 year follow-up on index treatment. Participants receiving DMF who were previously treated with FTY and those on FTY previously treated with DMF were excluded. Propensity score matching at baseline was used to match FTY-treated to DMF-treated participants. Time to 6-month confirmed disability worsening (⩾1-point increase on PDDS, sustained for ⩾6 months) was estimated using Cox regression. A sensitivity analysis was conducted to account for differences in the duration of index exposure between DMF and FTY groups. Results: After propensity score matching, 468 DMF-treated participants were matched with 468 FTY-treated participants. Median treatment duration was 3.0 years for DMF and 4.0 years for FTY. At 5 years, 68.3% [95% confidence interval (CI): 62.4–73.5] of DMF-treated participants and 63.3% (95% CI: 59.6–70.1) treated with FTY were free from 6-month confirmed PDDS worsening [hazard ratio (HR) 1.01 (95% CI: 0.79–1.28); p = 0.95]. Results were similar in the sensitivity analysis: 70.5% (95% CI: 61.8–77.6) of DMF-treated participants and 72.7% (95% CI: 65.4–78.6) of FTY-treated participants were free from 6-month confirmed PDDS worsening [HR: 1.04 (95% CI: 0.71–1.51); p = 0.84]. Conclusions: In participants with MS from the NARCOMS registry, there was no significant difference in confirmed disability (PDDS) worsening over 5 years between those treated with DMF versus FTY.
Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis
Authors: Yin Jun , Dawood Shaheenah , Cohen Romain , Meyers Jeff , Zalcberg John , Yoshino Takayuki , Seymour Matthew , Maughan Tim , Saltz Leonard , Van Cutsem Eric , Venook Alan , Schmoll Hans-Joachim , Goldberg Richard , Hoff Paulo , Hecht J. Randolph , Hurwitz Herbert , Punt Cornelis , Diaz Rubio Eduard , Koopman Miriam , Cremolini Chiara , Heinemann Volker , Tournigard Christophe , Bokemeyer Carsten , Fuchs Charles , Tebbutt Niall , Souglakos John , Doulliard Jean-Yves , Kabbinavar Fairooz , Chibaudel Benoist , de Gramont Aimery , Shi Qian , Grothey Axel , Adams Richard 
Published: June 2021

Background: Benchmarking international cancer survival differences is necessary to evaluate and improve healthcare systems. Our aim was to assess the potential regional differences in outcomes among patients with metastatic colorectal cancer (mCRC) participating in international randomized clinical trials (RCTs). Design: Countries were grouped into 11 regions according to the World Health Organization and the EUROCARE model. Meta-analyses based on individual patient data were used to synthesize data across studies and regions and to conduct comparisons for outcomes in a two-stage random-effects model after adjusting for age, sex, performance status, and time period. We used mCRC patients enrolled in the first-line RCTs from the ARCAD database, which provided enrolling country information. There were 21,509 patients in 27 RCTs included across the 11 regions. Results: Main outcomes were overall survival (OS) and progression-free survival (PFS). Compared with other regions, patients from the United Kingdom (UK) and Ireland were proportionaly over-represented, older, with higher performance status, more frequently male, and more commonly not treated with biological therapies. Cohorts from central Europe and the United States (USA) had significantly longer OS compared with those from UK and Ireland ( p = 0.0034 and p < 0.001, respectively), with median difference of 3–4 months. The survival deficits in the UK and Ireland cohorts were, at most, 15% at 1 year. No evidence of a regional disparity was observed for PFS. Among those treated without biological therapies, patients from the UK and Ireland had shorter OS than central Europe patients ( p < 0.001). Conclusions: Significant international disparities in the OS of cohorts of mCRC patients enrolled in RCTs were found. Survival of mCRC patients included in RCTs was consistently lower in the UK and Ireland regions than in central Europe, southern Europe, and the USA, potentially attributed to greater overall population representation, delayed diagnosis, and reduced availability of therapies.
Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis
Authors: Sestan Mario , Kifer Nastasia , Frkovic Marijan , Sapina Matej , Srsen Sasa , Batnozic Varga Mateja , Ovuka Aleksandar , Held Martina , Gudelj Gracanin Ana , Kozmar Ana , Bulimbasic Stela , Coric Marijana , Laskarin Gordana , Gagro Alenka , Jelusic Marija 
Published: June 2021

Background: We analysed clinical and biochemical parameters in predicting severe gastrointestinal (GI) manifestations in childhood IgA vasculitis (IgAV) and the risk of developing renal complications. Methods: A national multicentric retrospective study included children with IgAV reviewed in five Croatian University Centres for paediatric rheumatology in the period 2009–2019. Results: Out of 611 children, 281 (45.99%) had at least one GI manifestation, while 42 of 281 (14.95%) had the most severe GI manifestations. Using logistic regression several clinical risk factors for the severe GI manifestations were identified: generalized rash [odds ratio (OR) 2.09 (95% confidence interval (CI) 1.09–4.01)], rash extended on upper extremities (OR 2.77 (95% CI 1.43–5.34)] or face [OR 3.69 (95% CI 1.42–9.43)] and nephritis (IgAVN) [OR 4.35 (95% CI 2.23–8.50)], as well as lower values of prothrombin time (OR 0.05 (95% CI 0.01–0.62)], fibrinogen [OR 0.45 (95% CI 0.29–0.70)] and IgM [OR 0.10 (95% I 0.03–0.35)]] among the laboratory parameters. Patients with severe GI involvement more frequently had relapse of the disease [OR 2.14 (CI 1.04–4.39)] and recurrent rash [OR 2.61 (CI 1.27–5.38)]. Multivariate logistic regression found that the combination of age, GI symptoms at the beginning of IgAV and severity of GI symptoms were statistically significant predictors of IgAVN. Patients in whom IgAV has started with GI symptoms [OR 6.60 (95% CI 1.67–26.06)], older children [OR 1.22 (95% CI 1.02–1.46)] with severe GI form of IgAV (OR 5.90 (95% CI 1.12–31.15)] were particularly high-risk for developing IgAVN. Conclusion: We detected a group of older children with the onset of GI symptoms before other IgAV symptoms and severe GI form of the IgAV, with significantly higher risk for acute and chronic complications of IgAV.
Impaired muscle capacity of the hip and knee in individuals with isolated patellofemoral osteoarthritis: a cross-sectional study
Authors: Carvalho Cristiano , Serrão Fábio Viadanna , Mancini Letícia , Serrão Paula Regina Mendes da Silva 
Published: June 2021

Aims: The aims of this study were to compare the capacity of the knee and hip muscles between individuals with and without isolated patellofemoral osteoarthritis (PFOA) and to evaluate the impact of PFOA on pain, stiffness, and physical function. Methods: This cross-sectional study evaluated muscle capacity of the hip and knee using an isokinetic dynamometer. The isokinetic variables used in the statistical analysis were peak torque, total work, and average power. Pain, stiffness, and physical function were assessed using questionnaires. Results: A total of 26 individuals participated in the study (13 with PFOA and 13 controls). The PFOA group exhibited lower peak torque, total work, and average power for knee extension and flexion in the concentric mode ( p ⩽ 0.01) as well as lower peak torque and total work for knee extension ( p ⩽ 0.005) and lower total work for knee flexion ( p = 0.05) in the eccentric mode. The PFOA group exhibited lower peak torque of the extensor, abductor, adductor, and internal rotator muscles of the hip ( p ⩽ 0.05), less total work of the abductor and adductor muscles ( p ⩽ 0.04), and lower average power of eccentric adduction of the hip ( p = 0.01) compared with the healthy controls. Compared with the control group, the PFOA group had a higher level of pain, stiffness, and compromised physical functioning self-reported ( p ⩽ 0.005). Conclusion: Participants with PFOA exhibited impairments regarding muscle capacity of the hip and knee, higher level of pain and stiffness as well as compromised physical functioning in comparison with healthy controls.