bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Multi-Criteria Decision Analysis Technique Incorporating Demanding Essential Characteristics of Existing MCDA Techniques
Authors: Bandyopadhyay Susmita 
Published: December 2021

Abstract
This paper has proposed a novel Multi-Criteria Decision Analysis (MCDA) technique that considers relationships among the criteria, relationships among the alternatives, relationships among the criteria and the alternatives, the uncertainty or dilemma that the decision makers face in their decision-making, the entropy among the criteria. These characteristics seem to be the essential characteristics of various MCDA techniques as evident from the existing literature. The dilemma of the decision makers have been captured by the use of Hesitant Fuzzy Elements; the information content among the criteria have been captured by applying the concept of entropy through the application of a technique called IDOCRIW. Relationships have been determined by calculating the covariances among the criteria and among the alternatives. A kind of sensitivity analysis, rank reversal method has been performed to verify the effectiveness of the proposed technique. The proposed method has also been compared with four different types of already existing MCDA techniques, AHP, MAUT, MACBETH and MOORA. Both the sensitivity analysis and the comparison with other methods establish the effectiveness of the proposed technique.
Clinical and Molecular Features of Disseminated Pediatric Low Grade Glioma - A Systematic Review of Literature
Authors: Haizel-Cobbina Joseline , Thakkar Rut , Richard Kelsey , Levine Adrian , Bennett Julie , Hawkins Cynthia , Tabori Uri , Dewan Michael C. 
Published: December 2021

Abstract
INTRODUCTIONGliomas account for approximately 46% of all pediatric CNS tumors. There is growing awareness of pediatric low-grade gliomas (PLGG) that disseminate to distant parenchymal or leptomeningeal locations either at the time of initial diagnosis or upon disease surveillance. Disseminated PLGGs (dPLGGs) are associated with a poorer prognosis than non-disseminated PLGGs. To date there is no comprehensive report characterizing the genome profile of dPLGGs and their associated management. This systematic review aims to identify the pattern of genetic alterations and treatment outcomes described for dPLGG.METHODSA systematic review of the literature was performed to identify relevant articles. A quality and risk of bias assessment of articles was done using the GRADE framework and ROBINS-I tool, respectively.RESULTSFifty-two studies published from 1994 to 2020 were included in this review with 368 cases reported. There was sporadic reporting of genetic alterations. The most common genetic alteration observed among study subjects was 1p deletion (76%) and BRAF-KIAA1549 fusion (55%). BRAF p.V600E mutation was found in 7% of subjects. A higher proportion of cases demonstrated primary dissemination compared to secondary dissemination (65% vs 25%). First-line chemotherapy consisted primarily of an alkylation-based regimen and vinca alkaloids. Surgical intervention ranged from biopsy alone to surgical resection and CSF diversion, and depended largely upon tumor location and timing of dissemination. Overall, 73% of cases were alive at last follow-up (median, 40.2 months). All studies reviewed either ranked low or moderate for both quality and risk of bias assessments. CONCLUSIONWhile 1p deletion and BRAF-KIAA1549 fusion are the most commonly described molecular alterations in dPLGG, these tumors appear to express heterogeneous molecular and biological characteristics distinct from non-disseminated PLGGs. Additional studies on the molecular and biological features of these tumors are needed to better understand the pathogenesis of dPLGG and to inform the development of additional targeted regimens.
Metabolomics Profile in Acute Respiratory Distress Syndrome By Nuclear Magnetic Resonance Spectroscopy In Patients With Community-Acquired Pneumonia
Authors: Yan Yongqin , Chen Jianuo , Liang Qian , Zheng Hong , Ye Yiru , Nan Wengang , Gao Hongchang , Li Yuping 
Published: December 2021

Abstract
Background: Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. To date, no standardized diagnostic biomarker has been validated for community-acquired pneumonia (CAP)-induced ARDS. An integrated analysis of changes in the metabolic profile could help detect biomarkers for early prediction of ARDS development and evaluation of treatment efficacy.Methods: A total of 88 patients were enrolled for the final analysis and divided into two groups: the ARDS group (n = 43) and the no-ARDS group (n = 45). We examined differences in serum and urine metabolites and explored dynamic changes with nuclear magnetic resonance (NMR) spectroscopy.Results: A total of 20 serum and 42 urine metabolites were identified using NMR spectroscopy. Serum metabolites, including leucine, 3-hydroxybutyrate, lactate, acetone, citrate, and choline, and urine metabolites, including creatine and creatinine, could distinguish patients with CAP with and without ARDS, with areas under the receiver operating characteristic curve (AUC) values of 0.790 and 0.747, respectively. The treatment efficacy of patients with ARDS was achieved at an AUC of 0.862 with serum metabolites 3-hydroxybutyrate, lactate, acetone, acetoacetate, citrate, and choline, and of 0.691 with urine metabolites taurine and glucose. The treatment efficacy of patients without ARDS was achieved at an AUC of 0.845 with serum metabolites alanine, acetate, acetoacetate, glutamine, creatine, and glucose and 0.891 with urine metabolites choline, tryptamine, and 3-indoxyl sulfate. We also proposed a combined biomarker of associated serum and urine metabolites to predict ARDS in patients with CAP (AUC = 0.865) and evaluate treatment efficacy for patients with and without ARDS (AUC = 0.921 and 0.893, respectively).Conclusions: Serum and urine analyses showed that metabolomics provides potential circulatory markers for early prediction and evaluation of treatment efficacy in patients with CAP with and without ARDS.
The Effect of Cognitive Functional Therapy for Chronic Nonspecific Low Back Pain: Systematic Review and Meta-analysis
Authors: Miki Takahiro , Kondo Yu , kurakata Hiroshi , Buzasi Eva , Takebayashi Tsuneo , Takasaki Hiroshi 
Published: December 2021

Abstract
BackgroundTo apply the Bio-Psych-Social (BPS) model into clinical practice, it is important not to focus on psychosocial domains only since biomedical factors can also contribute to chronic pain conditions. The cognitive functional therapy (CFT) is the management system based on the BPS model for chronic nonspecific low back pain (CNSLBP). ObjectivesTo compare CFT with the other interventions for CNSLBP regarding pain, disability/functional status, QoL and psychological factors. DesignSystematic review and meta-analysis. MethodLiterature Search was conducted in electronic search engines. Enrolled participants included 1) CNSLBP and 2) primary, secondary, or tertiary care patients. CFT was the interventions included. Comparisons were any types of treatment. ResultsThree studies met the eligibility criteria. The total number of participants was 336. For pain intensity, MD [95% CIs] was -2.78 [-2.78−0.02] and -1.01 [-1.92−-0.10] at intermediate and long term for two studies, respectively. About disability/functional status, SMD [95% CIs] was -0.76 [-1.46−-0.07]　at the intermediate for three studies and MD [95% CIs] was -0.84 [-11.47−-5.49] at long term for two studies. About fear of physical activity, MD [95% CIs] was -3.01 [-5.14−-0.88] and -3.56 [-6.43−-0.68] at intermediate and long term for two studies, respectively. No studies reported scores associated with QOL. All the quality of the evidence was very low. ConclusionsThree studies were included and the quality of all the evidence was very low. Although the study found statistically significant differences in some measures, the effectiveness of the CFT will need to be re-evaluated in the future.PROSPERO registration number CRD42020158182
Divergent Design of Mechanical Metamaterials Clan Deducted from Arc-serpentine Curve
Authors: Mi Shengli , Yao Hongyi , Zhao Xiaoyu , Sun Wei 
Published: December 2021

Abstract
The exotic properties of mechanical metamaterials are determined by their unit-cells' structure and spatial arrangement, in analogy with the atoms of conventional materials. Companioned with the mechanism of structural or cellular materials1–5, the ancient wisdom of origami6–11 and kirigami12–16 and the involvement of multiphysics interaction2,17,18 enrich the programable mechanical behaviors of metamaterials, including shape-morphing8,12,14,16,19, compliance4,5,8,17,20, texture2,18,21, and topology11,18,22−25. However, typical design strategies are mainly convergent, which transfers various structures into one family of metamaterials that are relatively incompatible with the others and do not fully bring combinatorial principles3,10,26 into play. Here, we report a divergent strategy that designs a clan of mechanical metamaterials with diverse properties derived from a symmetric curve consisting of serpentines and arcs. We derived this composite curve into planar and cubic unit-cells and modularized them by attaching magnetics. Moreover, stacking each of them yields two- and three-dimensional auxetic metamaterials, respectively. Assembling with both modules, we achieved three thick plate-like metamaterials separately with flexibility, in-plane buckling, and foldability. Furthermore, we demonstrated that the hybrid of paradox properties is possible by combining two of the above assembles. We anticipate that this divergent strategy paves the path of building a hierarchical library of diverse combinable mechanical metamaterials and making conventional convergent strategies more efficient to various requests. Main
Calorimetric study of skutterudite (CoAs2.92) and heazlewoodite (Ni3S2)
Authors: Majzlan Juraj , Kiefer Stefan , Lilova Kristina , Subramani Tamilarasan , Navrotsky Alexandra , Tuhý Marek , Vymazalová Anna , Chareev Dmitriy A. , Dachs Edgar , Benisek Artur 
Published: December 2021

Abstract
Nickel and cobalt arsenides, sulfarsenides, and sulfides occur in many hydrothermal ore deposits, but their thermodynamic properties are not well known, in some cases not known at all. In this work, we determined a full set of thermodynamic properties for heazlewoodite and skutterudite. Both phases were synthesized in evacuated silica tubes at elevated temperatures, and electron microprobe analyses gave their compositions as Ni3S2 and CoAs2.92, respectively. Enthalpies of formation were measured by high-temperature oxide-melt solution calorimetry. The reference phases were pure elements, thus eliminating any systematic errors related to such phases. The enthalpies of formation at T = 298.15 K and P = 105 Pa are –216.0 ± 8.4(2σ) and –88.2 ± 6.1 kJ·mol−1 for Ni3S2 and CoAs2.92, respectively. Entropies were calculated from low-temperature heat capacity (CP) data from relaxation (PPMS) calorimetry and are 133.8 ± 1.6 and 106.4 ± 1.3 J·mol–1·K–1, respectively. The calculated Gibbs free energies of formation are –210.0 ± 8.4 and –79.9 ± 6.2 kJ·mol−1 for Ni3S2 and CoAs2.92, respectively. The PPMS CP data, together with a set of differential scanning calorimetry measurements, were used to derive CP polynomials up to 700 K with the Kieffer model based on previously published frequencies of acoustic and optic modes. Equilibrium constants for selected reactions with an aqueous phase were calculated up to 700 K. Geochemical modeling in these systems, however, should await until more reliable data for other phases from the system Co-Ni-As-S are available.
S16020 Pyridocarbazole Derivatives Display High Activity to Lung Cancer Cells
Authors: Chabowska Gabriela , Moreira Helena , Tylińska Beata , Barg Ewa 
Published: December 2021

Background:
Despite the dynamic development of medicine, globally cancer diseases remain the second
leading cause of death. Therefore, there is a strong necessity to improve chemotherapy regimens and search for new
anticancer agents. Pyridocarbazoles are compounds with confirmed antitumor properties based on multimodal mechanisms,
i.e. DNA intercalation and topoisomerase II-DNA complex inhibition. One of them, S16020, displayed a wide
spectrum of activity.

Objective:
The aim of the study was to investigate the antitumor potency of six S16020 derivatives, synthesized according
to the SAR (structure-activity relationship) method.

Methods:
The biological evaluation included influence on cancer cell viability, proliferation, and migration, as well as
P-glycoprotein activity. NHDF, A549, MCF-7, LoVo, and LoVo/DX cell lines were used in the study.

Results:
All derivatives displayed low toxicity to normal (NHDF) cells at 1 and 2 μM (≤ 20% of cell growth inhibition).
The highest reduction in cell viability was noted in A549 cells, which was accompanied by significant disruption
of cells proliferation and motility. Compound 1 exhibited the strongest cytotoxic, antiproliferative, and antimigratory
effects, higher than the reference olivacine. A significant reduction in P-glycoprotein activity was found for derivatives
6 and 1.

Conclusion:
S16020 derivatives could be considered as potential candidates for new anticancer drugs.
Antihyperglycemic Activity of Aqueous Extract of Euphorbia guyoniana in
Streptozotocin-Induced Diabetic Rats
Authors: Amssayef Ayoub , Azzaoui Bouchra , Bouadid Ismail , Eddouks Mohamed 
Published: December 2021

Aims:
This work assessed the antihyperglycemic effect of Euphorbia guyoniana.

Background:
Euphorbia guyoniana (Boss. and Reut.) is widely used in traditional medicine.

Objective:
This study was designed to confirm this traditional use by assessing its antihyperglycemic
capacity in vivo.

Methods:
The effect of the aqueous extract of Euphorbia guyoniana (Boss. and Reut.) (60 mg/kg)
on glycemia in both normal and diabetic rats was evaluated. The glycogen content in the liver and
skeletal muscles (extensor digitorum longus and soleus) was measured. Furthermore, liver histopathological
analysis was performed.

Results:
The findings showed that Euphorbia guyoniana (Boss. and Reut.) exhibited a significant
decrease in glycaemia in diabetic rats (from 20±2 mmol/l to 5.5 mmol/l after 6 hours of oral administration;
p<0.0001 and from 20±2 mmol/l to 4.5 mmol/l after 7 days of once-daily repeated oral administration
of the aqueous Euphorbia guyoniana extract; p<0.0001). In addition, the extract increased
the glycogen content in the liver (41±4 mg/g versus 70±5 mg/g in normal and diabetic rats
respectively) and extensor digitorum longus (39±4 mg/g versus 60±1 mg/g in normal and diabetic
rats, respectively), and partially restored corporal weight in diabetic rats. Furthermore, this aqueous
extract has been shown to suppress hyperglycemia induced by glucose load in treated diabetic rats.
Additionally, hepatic histology in diabetic rats has been improved. This plant revealed the presence
of several phytochemical constituents and possessed antioxidant activity.

Conclusion:
The current study evidenced that Euphorbia guyoniana (Boss. and Reut.) has a beneficial
effect on improving hyperglycemia and glycogen depletion in the diabetic state.
Association between Food Intake and Overweight in Children Assisted by Primary Care
Authors: Lima Erivelton Sousa , Brandão Amanda de Castro Amorim Serpa , Gomes Junior Antonio Luiz , Moura Luana kelle Batista , Mesquita Gerardo Vasconcelos , da Silva Oliveira Adélia Dalva , Hartz Zulmira , Ramos Carmen Viana 
Published: December 2021

Background:
The child feed in the first two years of life is of fundamental importance for a healthy growth and development.

Aims:
To verify the association between food consumption indicators and overweight in children under the age of two, followed up by primary care health professionals.

Methods:
A cross-sectional study was conducted on 232 children assisted by primary care. A structured questionnaire was used with questions on sociodemographic data of mothers or guardians and food intake and anthropometric data of children. The analysis of the association between excess weight and food intake indicators was performed using the Pearson’s chi-square test (χ2) and Fisher’s exact test (f ˂ 5).

Results:
Regarding food intake in children under 6 months of age, 35.1% of the children were exclusively breastfed. Among children at the age of 6 to 23 months: 66.3% were on continued breastfeeding; 16.7% consumed adequate foods at the age of 6 to 8 months; 90.4% consumed foods that belonged to the six food groups; 76.3% consumed food at the minimum frequency and with adequate consistency; 88.9% consumed iron-rich and vitamin A-rich foods, and 59.3% consumed ultra-processed foods. Regarding nutritional status, 24.5% of the children were overweight.

Conclusion:
There was no statistically significant association between overweight and food consumption indicators among the surveyed children. However, exclusive breastfeeding was below the recommended level, a low percentage of the introduction of complementary foods at the appropriate age and high consumption of ultra-processed foods reveal the need to improve the assistance provided by primary care to this group.
Experiences of Family Members of Children with Autism
Authors: Maria Sousa de Carvalho Claudia , Caminha Morais Islana , da Silva Borges Juliana , Clara Araújo Oliveira Maria , Eduarda Sousa de Carvalho Ana , Cláudia Miranda Amorim Fernanda , Dalva da Silva Oliveira Adélia , Macêdo Magalhães Juliana , Angela Lo Schiavo Sarisawa Emilia , Sávia de Souza Araújo Adriana 
Published: December 2021

Introduction:

Autism spectrum disorder is characterized by the change in the behavior-interaction-communication, with different levels of impairment.

Objectives:
This study aims to describe the experiences of family members of children with autism and discuss strategies to improve the quality of life of family members.

Methods:
A descriptive, exploratory study with a qualitative approach was carried out in a self-help association for autism, located in the city of Teresina/PI, Brazil. Data collection took place in September and October 2019 through the application of a semi-structured interview. Eighteen (18) family members of children with autism in the Association of Friends of Autistic Individuals (AMA) participated in the study. Bardin’s content analysis was the technique used for data analysis.

Results:
The results showed experiences of negative feelings on the part of family members who lived with autistic children, such as frustration and pain, but also positive feelings of affection and dedication and state of neutrality. The daily life of family members involved the experience of difficulties due to the care of the autistic children, in addition to the lack of information regarding different cases of autism. Therefore, it is necessary to include family members and children in support networks with the objective of making them a part of society with the help of the multidisciplinary team.

Conclusion:
The present research showed that the experiences of family members of children with autism are difficult at first, but with daily learning and interaction, they become rewarding. The study also reinforces the importance of team in the care of autistic children and highlighted the relevance of improving the family’s quality of life, which can also reflect on the quality of care of that individual.
Measurement of Hemodynamic Parameters and Antidepressant Activity
in Hypertensive Rats Following Two Weeks Consumption of Acacia Tortilis
Leaves Extract
Authors: Serafi Abdulhalim , Azmat Aisha , Ahmed Muhammad , Bafail Mohammed , Hussain Zahir 
Published: December 2021

Background:
Depression is common in hypertensive patients, and monotherapy may
contribute to controlling depression in hypertensive patients and improving socioeconomic outcomes.
Previous studies have shown that Acacia tortilis possesses hypotensive activity.

Objectives:
The present study was planned to evaluate the hemodynamic activity and antidepressant
effects of an ethanolic extract of Acacia tortilis leaves (ATEL) in salt-induced hypertensive
rats.

Methods:
Sprague-Dawley rats were divided into 5 groups for experiments. The rats received respective
treatment for 15 days: G1: Control (C); G2: hypertensive control (HC: high dietary salt,
4% 10ml/kg); G3-5: HC+ ATEL (50, 100, 150mg/kg respectively). Cardiac hemodynamics (mean
arterial blood pressure: MAP and heart rate: HR) were measured in the anaesthetized rats by an invasive
method. For this method, one carotid artery was catheterized, a pressure catheter (pressure-
volume Millar microtip catheter connected to the Mikro-Tip Pressure-Volume System from
Ultra Foundation Systems, PowerLab) was inserted, and the blood pressure (MAP in mm Hg) and
HR (beats/min) were monitored continuously during the experiment. For the neuropharmacological
studies, antidepressant activity was assessed by a forced swim test on the 15th day.

Results:
A dose-dependent significant increase in mobility time was observed in rats (G3-5) treated
with HC + different doses of ATEL (p < 0.05). However, the mobility time was significantly reduced
by HC (G2) treatment compared to the control (p< 0.05). The hypertensive control (high dietary
salt: HC) group showed a significant increase in systolic blood pressure (SP), diastolic blood
pressure (DP), MAP and HR (p<0.05) compared to the control (G1) group. At all doses (50, 100,
and 150 mg/kg), MAP and HR were found to decrease significantly (p<0.05) compared to the values
in the HC (G2) group. Further analysis revealed an improvement in heart rate variability
(HRV) in ATEL-treated hypertensive rats.

Conclusion:
The present research suggests that increased dietary salt intake not only increases
blood pressure significantly but also increases depression. ATEL contains some efficacious constituents,
such as N, N-dimethyltryptamine (DMT: a 5-HT1A agonist), with predominant antidepressant
and antihypertensive activity. Hence, ATEL appears to be a valuable plant extract that can
be useful, at least as an adjunct, for therapy in patients who suffer from both depression and hypertension.
Characteristic Observation of Cordyceps Militaris (L) Wild Type Strain from Five Oil Palm Plantation in Muara Wahau East Borneo
Authors: Aprianda Edwin , Djajakirana Gunawan , Darmawan Darmawan 
Published: December 2021

Cordycep militaris (L) is known in oil palm plantations as a natural enemy of nettle caterpillars. This fungus infects the caterpillars that descend down to become pupae around the palm circle, so that the pupae do not develop into imago and the pest's life cycle will be interrupted. This fungus is one of the 3 main entomopathogenic fungi used as bioinsecticides to control pests in oil palm plantations. In this study, the characteristics of C. militaris were observed from 5 oil palm plantations cultured in vitro using two types of media and two incubation methods. The results showed that there were mycelium pigmentation in nutrient-rich media Sabouraud Dextrose Agar plus Yeast extract (SDAY) when incubated with lighting. Only one of five mycelium cultures using SDAY media showed pigmentation on the no-light incubation method. Pigmentation did not occur in nutrient-poor media such as agar (WA), either incubated with lighting or with no-light. The growth of isolates was generally higher on SDAY media than on WA media. This study showed that C. militaris is a facultative phagotrophic fungus. The highest growth of isolates cultured on SDAY media incubated with lighting was found in isolates A and C, with colony diameter 90 mm, high mycelium density (+++) and hairy texture like cotton at the end of the 3rd week after inoculation. In the no-light incubation method, the highest growth was found in isolates B and C with colony diameter 90 mm, high mycelium density (+++) and hairy texture like cotton at the end of the 3rd week after inoculation. Isolates A and C showed high virulence potential to be used as bioinsecticides.