bluuebunny/crossref_metadata_2025_split huggingface dataset:
The benefits of diligence: how precise are predicted gravitational wave spectra in models with phase transitions?
Authors: Guo Huai-Ke , Sinha Kuver , Vagie Daniel , White Graham 
Published: June 2021

Abstract
Models of particle physics that feature phase transitions typically provide predictions for stochastic gravitational wave signals at future detectors and such predictions are used to delineate portions of the model parameter space that can be constrained. The question is: how precise are such predictions? Uncertainties enter in the calculation of the macroscopic thermal parameters and the dynamics of the phase transition itself. We calculate such uncertainties with increasing levels of sophistication in treating the phase transition dynamics. Currently, the highest level of diligence corresponds to careful treatments of the source lifetime; mean bubble separation; going beyond the bag model approximation in solving the hydrodynamics equations and explicitly calculating the fraction of energy in the fluid from these equations rather than using a fit; and including fits for the energy lost to vorticity modes and reheating effects. The lowest level of diligence incorporates none of these effects. We compute the percolation and nucleation temperatures, the mean bubble separation, the fluid velocity, and ultimately the gravitational wave spectrum corresponding to the level of highest diligence for three explicit examples: SMEFT, a dark sector Higgs model, and the real singlet-extended Standard Model (xSM). In each model, we contrast different levels of diligence in the calculation and find that the difference in the final predicted signal can be several orders of magnitude. Our results indicate that calculating the gravitational wave spectrum for particle physics models and deducing precise constraints on the parameter space of such models continues to remain very much a work in progress and warrants care.
An explicit calculation of pseudo-goldstino mass at the leading three-loop level
Authors: Dai Jianpeng , Liu Tao , Yang Jin Min 
Published: June 2021

Abstract
Pseudo-goldstinos appear in the scenario of multi-sector SUSY breaking. Unlike the true goldstino which is massless and absorbed by the gravitino, pseudo-goldstinos could obtain mass from radiative effects. In this note, working in the scenario of two-sector SUSY breaking with gauge mediation, we explicitly calculate the pseudo-goldstino mass at the leading three-loop level and provide the analytical results after performing Taylor expansions in the loop integrals. In our calculation we consider the general case of messenger masses (not necessarily equal) and include the higher order terms of SUSY breaking scales. Our results can reproduce the numerical value estimated previously at the leading order of SUSY breaking scales with the assumption of equal messenger masses. It turns out that the results are very sensitive to the ratio of messenger masses, while the higher order terms of SUSY breaking scales are rather small in magnitude. Depending on the ratio of messenger masses, the pseudo-goldstino mass can be as low as $$ \mathcal{O} $$
O
(0.1) GeV.
Singlino-dominated dark matter in general NMSSM
Authors: Cao Junjie , Li Demin , Lian Jingwei , Yue Yuanfang , Zhou Haijing 
Published: June 2021

Abstract
The general Next-to-Minimal Supersymmetric Standard Model (NMSSM) describes the singlino-dominated dark-matter (DM) property by four independent parameters: singlet-doublet Higgs coupling coefficient λ, Higgsino mass μtot, DM mass $$ {m}_{{\tilde{\chi}}_1^0} $$

m

χ
˜

1
0

, and singlet Higgs self-coupling coefficient κ. The first three parameters strongly influence the DM-nucleon scattering rate, while κ usually affects the scattering only slightly. This characteristic implies that singlet-dominated particles may form a secluded DM sector. Under such a theoretical structure, the DM achieves the correct abundance by annihilating into a pair of singlet-dominated Higgs bosons by adjusting κ’s value. Its scattering with nucleons is suppressed when λv/μtot is small. This speculation is verified by sophisticated scanning of the theory’s parameter space with various experiment constraints considered. In addition, the Bayesian evidence of the general NMSSM and that of Z3-NMSSM is computed. It is found that, at the cost of introducing one additional parameter, the former is approximately 3.3 × 103 times the latter. This result corresponds to Jeffrey’s scale of 8.05 and implies that the considered experiments strongly prefer the general NMSSM to the Z3-NMSSM.
Data-driven topology design using a deep generative model
Authors: Yamasaki Shintaro , Yaji Kentaro , Fujita Kikuo 
Published: June 2021

AbstractIn this paper, we propose a sensitivity-free and multi-objective structural design methodology called data-driven topology design. It is schemed to obtain high-performance material distributions from initially given material distributions in a given design domain. Its basic idea is to iterate the following processes: (i) selecting material distributions from a dataset of material distributions according to eliteness, (ii) generating new material distributions using a deep generative model trained with the selected elite material distributions, and (iii) merging the generated material distributions with the dataset. Because of the nature of a deep generative model, the generated material distributions are diverse and inherit features of the training data, that is, the elite material distributions. Therefore, it is expected that some of the generated material distributions are superior to the current elite material distributions, and by merging the generated material distributions with the dataset, the performances of the newly selected elite material distributions are improved. The performances are further improved by iterating the above processes. The usefulness of data-driven topology design is demonstrated through numerical examples.
The roles of KIBS and R&D in the industrial diversification of regions
Authors: Content Jeroen , Cortinovis Nicola , Frenken Koen , Jordaan Jacob 
Published: June 2021

AbstractThere is a growing recognition of the importance of the creation of new industrial specialisations for sustained regional growth. However, path dependency often limits a region’s ability to do so, as the occurrence of new industrial specialisations is conditioned by its existing industrial base. In this paper, we use data for 269 NUTS-2 EU regions to examine whether regional Knowledge-Intensive Business Services (KIBS) and Research and Development (R&D) enhance the capacity of regions to specialise in new industries, against the forces of path dependence. Our findings show that both KIBS and R&D exercise direct positive effects on the creation of new industry specialisations and that professional-KIBS and public R&D impact negatively on the relatedness of new specialisations, while private R&D does so positively.
The mean seasonal cycle in relative sea level from satellite altimetry and gravimetry
Authors: Ray Richard D. , Loomis Bryant D. , Zlotnicki Victor 
Published: June 2021

AbstractSatellite altimetry and gravimetry are used to determine the mean seasonal cycle in relative sea level, a quantity relevant to coastal flooding and related applications. The main harmonics (annual, semiannual, terannual) are estimated from 25 years of gridded altimetry, while several conventional altimeter “corrections” (gravitational tide, pole tide, and inverted barometer) are restored. To transform from absolute to relative sea levels, a model of vertical land motion is developed from a high-resolution seasonal mass inversion estimated from satellite gravimetry. An adjustment for annual geocenter motion accounts for use of a center-of-mass reference frame in satellite orbit determination. A set of 544 test tide gauges, from which seasonal harmonics have been estimated from hourly measurements, is used to assess how accurately each adjustment to the altimeter data helps converge the results to true relative sea levels. At these gauges, the median annual and semiannual amplitudes are 7.1 cm and 2.2 cm, respectively. The root-mean-square differences with altimetry are 3.24 and 1.17 cm, respectively, which are reduced to 1.93 and 0.86 cm after restoration of corrections and adjustment for land motion. Example outliers highlight some limitations of present-day coastal altimetry owing to inadequate spatial resolution: upwelling and currents off Oregon and wave setup at Minamitori Island.
Prognostic value of regional myocardial flow reserve derived from 13N-ammonia positron emission tomography in patients with suspected coronary artery disease
Authors: von Felten Elia , Benz Dominik C. , Benetos Georgios , Baehler Jessica , Patriki Dimitri , Rampidis Georgios P. , Giannopoulos Andreas A. , Bakula Adam , Gräni Christoph , Pazhenkottil Aju P. , Gebhard Catherine , Fuchs Tobias A. , Kaufmann Philipp A. , Buechel Ronny R. 
Published: June 2021

AbstractPurposeTo assess the prognostic value of regional quantitative myocardial flow measures as assessed by13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD).MethodsWe retrospectively included 150 consecutive patients with suspected CAD who underwent clinically indicated 13 N-ammonia PET-MPI and who did not undergo revascularization within 90 days of PET-MPI. The presence or absence of a decreased global myocardial flow reserve (i.e., MFR < 2) as well as decreased regional MFR (i.e., ≥ 2 adjacent segments with MFR < 2) was recorded, and patients were classified as having preserved global and regional MFR (MFR group 1), preserved global but decreased regional MFR (MFR group 2), or decreased global and regional MFR (MFR group 3). We obtained follow-up regarding major adverse cardiac events (MACE, i.e., a combined endpoint including all-cause death, non-fatal myocardial infarction, and late revascularization) and all-cause death.ResultsOver a median follow-up of 50 months (IQR 38–103), 30 events occurred in 29 patients. Kaplan–Meier analysis showed significantly reduced event-free and overall survival in MFR groups 2 and 3 compared to MFR group 1 (log-rank: p = 0.015 and p = 0.013). In a multivariable Cox regression analysis, decreased regional MFR was an independent predictor for MACE (adjusted HR 3.44, 95% CI 1.17–10.11, p = 0.024) and all-cause death (adjusted HR 4.72, 95% CI 1.07–20.7, p = 0.04).ConclusionsA decreased regional MFR as assessed by 13 N-ammonia PET-MPI confers prognostic value by identifying patients at increased risk for future adverse cardiac outcomes and all-cause death.
Paradigm shift in acute dizziness: is caloric testing obsolete?
Authors: Morrison Miranda , Korda Athanasia , Zamaro Ewa , Wagner Franca , Caversaccio Marco D. , Sauter Thomas C. , Kalla Roger , Mantokoudis Georgios 
Published: June 2021

Abstract
Objective
Cold and warm water ear irrigation, also known as bithermal caloric testing, has been considered for over 100 years the ‘Gold Standard’ for the detection of peripheral vestibular hypofunction. Its discovery was awarded a Nobel Prize. We aimed to investigate the diagnostic accuracy of Caloric Testing when compared to the video head impulse test (vHIT) in differentiating between vestibular neuritis and vestibular strokes in acute dizziness.

Design
Prospective cross-sectional study (convenience sample).

Setting
All patients presenting with signs of an acute vestibular syndrome at the emergency department of a tertiary referral center.

Participants
One thousand, six hundred seventy-seven patients were screened between February 2015 and May 2020 for Acute Vestibular Syndrome (AVS), of which 152 met the inclusion criteria and were enrolled. Inclusion criteria consisted of a state of continuous dizziness, associated with nausea or vomiting, head-motion intolerance, new gait or balance disturbance and nystagmus. Patients were excluded if they were younger than 18 years, if symptoms lasted < 24 h or if the index ED visit was > 72 h after symptom onset. Of the 152 included patients 85 completed testing. We assessed 58 vestibular neuritis and 27 stroke patients.

Main outcome measures
All patients underwent calorics and vHIT followed by a delayed MRI which served as a gold standard for vestibular stroke confirmation.

Results
The overall sensitivity and specificity for detecting stroke with a caloric asymmetry cut-off of 30.9% was 75% and 86.8%, respectively [negative likelihood ratio (NLR) 0.29] compared to 91.7% and 88.7% for vHIT (NLR 0.094). Best VOR gain cut-off was 0.685. Twenty-five percent of vestibular strokes were misclassified by calorics, 8% by vHIT.

Conclusions
Caloric testing proved to be less accurate than vHIT in discriminating stroke from vestibular neuritis in acute dizziness. Contrary to classic teaching, asymmetric caloric responses can also occur with vestibular strokes and might put the patient at risk for misdiagnosis. We, therefore, recommend to abandon caloric testing in current practice and to replace it with vHIT in the acute setting. Caloric testing has still its place as a diagnostic tool in an outpatient setting.
Physical and psychosocial working conditions as predictors of 5-year changes in work ability among 2078 employees in Germany
Authors: Burr Hermann , Lange Stefanie , Freyer Marion , Formazin Maren , Rose Uwe , Nielsen Martin Lindhardt , Conway Paul Maurice 
Published: June 2021

Abstract
Objective
To examine 5-year prospective associations between working conditions and work ability among employees in Germany.

Methods
A cohort study (2011/2012–2017), based on a random sample of employees in employments subject to payment of social contributions aged 31–60 years (Study on Mental Health at Work; S-MGA; N = 2,078), included data on physical and quantitative demands, control (influence, possibilities for development, control over working time), relations (role clarity and leadership quality) and work ability (Work Ability Index, WAI; subscale ‘subjective work ability and resources’). Data were analysed using linear regression.

Results
Physical demands and control were associated with small 5-year changes in work ability (ΔR2 = 1%). Among the subgroup of employees with ≥ 25 sickness days, possibilities for development, control and quality of leadership were associated with changes in work ability (ΔR2 = 8%).

Conclusions
The impact of working conditions on long term changes in work ability seems to be negligible. However, in vulnerable subpopulations experiencing poor health, working conditions may be associated to a larger extent to work ability over this time span.
Exposure to cisplatin in the operating room during hyperthermic intrathoracic chemotherapy
Authors: Markowiak Till , Ried Michael , Larisch Christopher , Nowak Dennis , Hofmann Hans-Stefan , Rakete Stefan 
Published: June 2021

Abstract
Purpose
Hyperthermic intrathoracic chemotherapy (HITOC) is an additive, intraoperative treatment for selected malignant pleural tumors. To improve local tumor control, the thoracic cavity is perfused with a cisplatin-containing solution after surgical cytoreduction. Since cisplatin is probably carcinogenic to humans, potential contamination of surfaces and pathways of exposure should be systematically investigated to enable risk assessments for medical staff and thus derive specific recommendations for occupational safety.

Methods
Wipe sampling was performed at pre-selected locations during and after ten HITOC procedures, including on the surgeon's gloves, for the quantitation of surface contaminations with cisplatin. After extraction of the samples with hydrochloric acid, platinum was determined as a marker for cisplatin by voltammetry.

Results
High median concentrations of cytostatic drugs were detected on the surgeons’ (1.73 pg Cis-Pt/cm2, IQR: 9.36 pg Cis-Pt/cm2) and perfusionists’ (0.69 pg Cis-Pt/cm2, IQR: 1.73 pg Cis-Pt/cm2) gloves. The display of the perfusion device showed partially elevated levels of cisplatin up to 4.92 pg Cis-Pt/cm2 and thus could represent an origin of cross-contamination. In contrast, cisplatin levels on the floor surfaces in the area of the surgeon and the perfusion device or in the endobronchial tube were relatively low.

Conclusion
With a correct use of personal protective equipment and careful handling, intraoperative HITOC appears to be safe to perform with a low risk of occupational exposure to cisplatin.
Coronary angiography in patients after cardiac arrest without ST-elevation myocardial infarction
Authors: Mueller Matthias , Dziekan Daniela , Poppe Michael , Clodi Christian , Schriefl Christoph , Hofbauer Martin , Roth Christian , Nuernberger Alexander , Holzer Michael , Weiser Christoph 
Published: June 2021

Summary
Background
Coronary artery disease (CAD) is the most common cause of sudden cardiac arrest (SCA). Although coronary angiography (CAG) should be performed also in the absence of ST-elevation (STE) after sustained return of spontaneous circulation (ROSC), this recommendation is not well implemented in daily routine.

Methods
A retrospective database analysis was conducted in a tertiary care center between January 2005 and December 2014. We included all SCA patients aged ≥ 18 years with presumed cardiac cause and sustained ROSC in the absence of STE at hospital admission. The rate and timing of CAG were defined as the primary endpoints. As secondary endpoints, the reasons pro and contra CAG were analyzed. Furthermore, we observed if the signs and symptoms used for decision making occurred more often in patients with treatable CAD.

Results
We included 645 (53.6%) of the 1203 screened patients, CAG was performed in 343 (53.2%) patients with a diagnosis of occlusive CAD in 214 (62.4%) patients. Of these, 151 (71.0%) patients had occlusive CAD treated with coronary intervention, thrombus aspiration, or coronary artery bypass grafting. In an adjusted binomial logistic regression analysis, age ≥ 70 years, female sex, non-shockable rhythms, and cardiomyopathy were associated with withholding of CAG. In patients diagnosed and treated with occlusive CAD, initially shockable rhythms, previously diagnosed CAD, hypertension, and smoking were found more often.

Conclusion
Although selection bias is unavoidable due to the retrospective design of this study, a high proportion of the examined patients had occlusive CAD. The criteria used for patient selection may be suboptimal.
Citizen views on genome editing: effects of species and purpose
Authors: Busch Gesa , Ryan Erin , von Keyserlingk Marina A. G. , Weary Daniel M. 
Published: June 2021

AbstractPublic opinion can affect the adoption of genome editing technologies. In food production, genome editing can be applied to a wide range of applications, in different species and with different purposes. This study analyzed how the public responds to five different applications of genome editing, varying the species involved and the proposed purpose of the modification. Three of the applications described the introduction of disease resistance within different species (human, plant, animal), and two targeted product quality and quantity in cattle. Online surveys in Canada, the US, Austria, Germany and Italy were carried out with a total sample size of 3698 participants. Using a between-subject design, participants were confronted with one of the five applications and asked to decide whether they considered it right or wrong. Perceived risks, benefits, and the perception of the technology as tampering with nature were surveyed and were complemented with socio-demographics and a measure of the participants’ moral foundations. In all countries, participants evaluated the application of disease resistance in humans as most right to do, followed by disease resistance in plants, and then in animals, and considered changes in product quality and quantity in cattle as least right to do. However, US and Italian participants were generally more positive toward all scenarios, and German and Austrian participants more negative. Cluster analyses identified four groups of participants: ‘strong supporters’ who saw only benefits and little risks, ‘slight supporters’ who perceived risks and valued benefits, ‘neutrals’ who showed no pronounced opinion, and ‘opponents’ who perceived higher risks and lower benefits. This research contributes to understanding public response to applications of genome editing, revealing differences that can help guide decisions related to adoption of these technologies.
Targeted acetylation of wood: a tool for tuning wood-water interactions
Authors: Digaitis Ramūnas , Thybring Emil E. , Thygesen Lisbeth G. , Fredriksson Maria 
Published: June 2021

Abstract
Wood is an increasingly important material in the sustainable transition of societies worldwide. The performance of wood in structures is intimately tied to the presence of moisture in the material, which directly affects important characteristics such as dimensions and mechanical properties, and indirectly its susceptibility to fungal decomposition. By chemical modification, the durability of wood in outdoor environments can be improved by reducing the amount of moisture present. In this study, we refined a well-known chemical modification with acetic anhydride and showed how the spatial distribution of the modification of Norway spruce (Picea abies (L.) Karst.) could be controlled with the aim of altering the wood-water interactions differently in different parts of the wood structure. By controlling the reaction conditions of the acetylation it was possible to acetylate only the cell wall-lumen interface, or uniformly modify the whole cell wall to different degrees. The spatial distribution of the acetylation was visualised by confocal Raman microspectroscopy. The results showed that by this targeted acetylation procedure it was possible to independently alter the wood-water interactions in and outside of cell walls. The cell wall-lumen interface modification altered the interaction between the wood and the water in cell lumina without affecting the interaction with water in cell walls while the uniform modification affected both. This opens up a novel path for studying wood-water interactions in very moist environments and how moisture distribution within the wood affects its susceptibility towards fungal decomposition.

Graphic abstract