bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attenuation of negative effects of saline stress in wheat plant by chitosan and calcium carbonate
Authors: Sadak Mervat Sh. , Talaat Iman M. 
Published: July 2021

Abstract
Background
Chitosan and Ca+ are natural signal molecules that can be used in agriculture as biostimulants and elicitors. They enhance different physiological responses and mitigate the negative effects of salinity. So, this investigation was done to study the effect of soaking wheat grains in chitosan and CaCO3 (20 and 40 mg/L) on alleviating the adverse effect of salinity stress (0.0 and 5000 mg/L) on growth, some biochemical and physiological and yields of wheat plant.

Results
Shoot length (cm), leaves no/tiller, shoot dry weight (g), root fresh weight (g) and root dry weight (g) were significantly decreased as a result of salt stress. Soaking wheat grains in Chitosan or CaCO3 significantly promoted plant growth under normal and stressed conditions. Irrigation of wheat plants with saline water significantly decreased photosynthetic pigments (Chlo-a, Chlo-b, carotenoids and total pigments) in addition to Chlo-a/Chlo-b ratio, indole acetic acid content in the plant leaves. Meanwhile, saline water significantly increased phenolics, total soluble sugars (TSS) and proline content. H2O2 and lipid peroxidation expressed by malondialdehyde (MDA) content clearly showed significant increases under salinity stress compared with untreated control. Soaking wheat grains in chitosan or CaCO3 before sawing significantly increased the accumulation of H2O2 and MDA in the leaves of wheat plants. Treatment of wheat grains with chitosan or CaCO3 significantly promoted the activity of various antioxidant enzymes (SOD and POX) as compared to the control. CAT activity was significantly decreased as a result of chitosan or CaCO3 treatments. The highest CAT activity was recorded in plants irrigated with 5000 mg/L saline water followed by control plants which recoded 36.40 and 24.82 U/min/g FW, respectively. On the other hand, irrigation of wheat plants with 5000 mg/L saline water significantly decreased spike length (cm), spikelets no/spike, grains wt/plant (g), 1000-grains wt (g), yield and biomass/plant (g) as well as, carbohydrate % and protein % compared with the control. However, treating wheat plants either with Chitosan or calcium carbonate resulted in obvious significant increases in carbohydrates and protein contents, especially in plants treated with 40 mg/L chitosan followed by 40 mg/L calcium carbonate. Soaking wheat grains in chitosan, especially at 40 mg/L, exhibited the strongest scavenging potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay (DPPH%) followed by treatment with 40 mg/L CaCO3.

Conclusion
In conclusion, the used treatment enhanced the protective parameters such as antioxidant enzymes, total phenols and free radical scavengers and consequently helped the plants to decrease lipid peroxidation, increased their tolerance and improved yield and spike quality. Application of 40 mg/L chitosan recorded the highest increment in the scavenging ability of the natural antioxidants of the plant extract toward the stable free radical DPPH.
Working with laboratory rodents in Spain: a survey on welfare and wellbeing
Authors: Goñi-Balentziaga Olatz , Ortega-Saez Iván , Vila Sergi , Azkona Garikoitz 
Published: July 2021

Abstract
Background
Replacement, reduction and refinement, the 3R principles, provide a framework to minimize the use and suffering of animals in science. In this context, we aimed to determine the actual perception that individuals working with laboratory rodents in biomedical research have on animal welfare and on their interaction with the animals, as well as how they perceive its impact on their social relations. To this end, we designed an anonymous on-line survey for people working with rodents, at three responsibility levels, in Spain.

Results
Of the 356 participants, 239 were women (67 %); 263 were researchers (74 %), and 93 animal facility staff (26 %), of which 55 were caretakers/technicians (15 %), and 38 welfare officer/veterinarians (11 %). Animal facility staff indicated environmental enrichment to be a universal practice. About half of the participants reported that, in their opinion, animals suffer “little to none” or “minor” stress and pain. Animal caretakers/technicians and researchers perceived higher levels of stress and pain than welfare officers/veterinarians. Participants judged decapitation the most unpleasant method to kill rodents, whereas anaesthetic overdose was the least one. A sizable proportion − 21 % of animal caretakers/technicians and 11.4 % of researchers - stated that they were never given the choice not to euthanize the rodents they work with. Overall, women reported higher interactions with animals than men. Nevertheless, we could detect a significant correlation between time spent with the animals and interaction scores. Notably, 80 % of animal facility staff and 92 % of researchers rarely talked about their work with laboratory rodents with people outside their inner social circle.

Conclusions
Overall, the participants showed high awareness and sensitivity to rodent wellbeing; animal facility staff reported a similar perception on welfare questions, independently of their category, while researchers, who spent less time with the animals, showed less awareness and manifested lower human-animal interaction and less social support. Regarding the perception on social acceptance of laboratory animal work, all groups were cautious and rarely talked about their job, suggesting that it is considered a sensitive issue in Spain.
Added value of diffusion-weighted MRI in assessment of pleural lesions
Authors: Sabri Youssriah Yahia , Mahmoud Ikram Hamed , El-Gendy Lamis Tarek , Abd El-Mageed Mohamed Raafat , Tadros Sally Fouad 
Published: July 2021

Abstract
Background
There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water molecules diffusivity. The aim of this study was to evaluate the diagnostic value of DWI-MRI in detection and characterization of pleural diseases and its capability in differentiating benign from malignant pleural lesions.

Results
Conventional MRI was able to discriminate benign from malignant lesions by using morphological features (contour and thickness) with sensitivity 89.29%, specificity 76%, positive predictive value 89%, negative predictive value 76.92%, and accuracy 85.37%. ADC value as a quantitative parameter of DWI found that ADC values of malignant pleural diseases were significantly lower than that of benign lesions (P < 0.001). Hence, we discovered that using ADC mean value of 1.68 × 10-3 mm2/s as a cutoff value can differentiate malignant from benign pleural diseases with sensitivity 89.3%, specificity 100%, positive predictive value 100%, negative predictive value 81.2%, and accuracy 92.68% (P < 0.001).

Conclusion
Although DWI-MRI is unable to differentiate between malignant and benign pleural effusion, its combined morphological and functional information provide valid non-invasive method to accurately characterize pleural soft tissue diseases differentiating benign from malignant lesions with higher specificity and accuracy than conventional MRI.
Marginal mandibular nerve — a wandering enigma and ways to tackle it
Authors: Kudva Adarsh , Babu Kiruthika , Saha Mehul , Puri Smriti , Pandey Lakshmi , Gunashekhar Shruti 
Published: July 2021

Abstract
Background
This study aims to propose surgical approaches intended to localize and preserve the marginal mandibular nerve (MMN) during routinely performed head and neck surgical procedures.

Main body of abstract
Preservation of the functional integrity of the MMN is a critical measure in the success of orofacial surgeries involving the submandibular triangle. This study systematically reviews the anatomical description of the nerve including origin, course relative to fascial planes, relation to the parotid gland and facial pedicle, branching pattern and anastomosis of nerve and consolidate the findings of several significant studies to determine the “surgically safe” approaches to avoid iatrogenic injury to MMN.

Short conclusion
The systematic approaches described in this study have helped the authors precisely determine which particular MMN preserving approach to be adopted for each aspect of head and neck surgery. This has definitely enhanced the quality of surgery performed and the postoperative satisfaction of the patients.
Endoscopic endonasal cerebrospinal fluid rhinorrhea repair: a cohort study in Iraq
Authors: Hasan Ammar Abdulkadhim , Al-Saedi Saad Farhan , Saleh Mukhallad Mahdi , Al-Akbi Hani Musa 
Published: July 2021

Abstract
Background
Cerebrospinal fluid (CSF) rhinorrhea is a condition where the protective fluid that surrounds the brain finds its way into the nose and sinuses, often appearing as a very watery runny nose. The main surgical approaches for the surgical repair of CSF leaks are intracranial and extracranial. Over the last decade, endoscopic surgery has established itself as the most widely used technique for the repair of CSF fistula. The current study aimed to describe the use of nasal endoscopic technique in the management of cerebrospinal fluid rhinorrhea repair.

Results
Results of our study showed that in addition to CSF leak, 40% of the patients had headache and 17.5% had repeated meningitis. Half of the etiologies for the CSF leak were spontaneous, 35% were congenital, and 15% were traumatic. The more frequent site of leak was left cribriform plate (37.5%). In the majority of patients, 37/40 (92.5%), the type of graft was tensor fascia lata and fat, while in the remaining 3 patients, type of graft was tensor fascia lata and bone, bone and fat, and tensor fascia lata. The repair succeeded in 35 patients giving a success rate of 87.5%.

Conclusion
It can be concluded that wide range of age groups from 2–62 years presented as CSF rhinorrhea with female predominance, and there was high success rate of endoscopic CSF rhinorrhea repair with low morbidity.
Lenvatinib Targets PDGFR-β Pericytes and Inhibits Synergy With Thyroid Carcinoma Cells: Novel Translational Insights
Authors: Iesato Asumi , Li Stephanie , Roti Giovanni , Hacker Michele R , Fischer Andrew H , Nucera Carmelo 
Published: July 2021

AbstractContextPericyte populations abundantly express tyrosine kinases (eg, platelet-derived growth factor receptor-β [PDGFR-β]) and impact therapeutic response. Lenvatinib is a clinically available tyrosine kinase inhibitor that also targets PDGFR-β. Duration of therapeutic response was shorter in patients with greater disease burden and metastasis. Patients may develop drug resistance and tumor progression.ObjectivesDevelop a gene signature of pericyte abundance to assess with tumor aggressiveness and determine both the response of thyroid-derived pericytes to lenvatinib and their synergies with thyroid carcinoma-derived cells.DesignUsing a new gene signature, we estimated the relative abundance of pericytes in papillary thyroid carcinoma (PTC) and normal thyroid (NT) TCGA samples. We also cocultured CD90+;PAX8- thyroid-derived pericytes and BRAFWT/V600E-PTC-derived cells to determine effects of coculture on paracrine communications and lenvatinib response.ResultsPericyte abundance is significantly higher in BRAFV600E-PTC with hTERT mutations and copy number alterations compared with NT or BRAFWT-PTC samples, even when data are corrected for clinical-pathologic confounders. We have identified upregulated pathways important for tumor survival, immunomodulation, RNA transcription, cell-cycle regulation, and cholesterol metabolism. Pericyte growth is significantly increased by platelet-derived growth factor-BB, which activates phospho(p)-PDGFR-β, pERK1/2, and pAKT. Lenvatinib strongly inhibits pericyte viability by down-regulating MAPK, pAKT, and p-p70S6-kinase downstream PDGFR-β. Critically, lenvatinib significantly induces higher BRAFWT/V600E-PTC cell death when cocultured with pericytes, as a result of pericyte targeting via PDGFR-β.ConclusionsThis is the first thyroid-specific model of lenvatinib therapeutic efficacy against pericyte viability, which disadvantages BRAFWT/V600E-PTC growth. Assessing pericyte abundance in patients with PTC could be essential to selection rationales for appropriate targeted therapy with lenvatinib.
An alternative sedation option for special care patients: combined inhalation sedation with nitrous oxide and oxygen and intravenous sedation with midazolam
Authors: Fenesan Stephanie , Hughes Sadie , Patel Neha 
Published: July 2021

This article highlights an alternative sedation technique by providing inhalation sedation with nitrous oxide and oxygen alongside intravenous sedation with midazolam as an additional option for patients within special care dentistry. Two case reports are described, as well as a short overview of the available literature on this technique and the indications, advantages and disadvantages. This technique should be considered alongside other sedation techniques. As with all treatment for which sedation is provided, each case needs to be considered on an individual basis and the most appropriate option selected following discussion with the patient. CPD/Clinical Relevance: Although single sedation techniques provide a good level of sedation to facilitate dental treatment for the majority of patients, it is desirable to have an awareness of alternative sedation options that may be available for patients.
Enhanced attraction of sand fly vectors of Leishmania infantum to dogs infected with zoonotic visceral leishmaniasis
Authors: Chelbi Ifhem , Maghraoui Khouloud , Zhioua Sami , Cherni Saifedine , Labidi Imen , Satoskar Abhay , Hamilton James G. C. , Zhioua Elyes 
Published: July 2021

Background
The sand fly Phlebotomus perniciosus is the main vector of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis in the Western Mediterranean basin. Dogs are the main reservoir host of this disease. The main objective of this study was to determine, under both laboratory and field conditions, if dogs infected with L. infantum, were more attractive to female P. perniciosus than uninfected dogs.

Methodology/Principal findings
We carried out a series of host choice experiments and found that infected dogs were significantly more attractive to P. perniciosus than uninfected dogs in the laboratory as well as in the field. Significantly more P. perniciosus fed on infected dogs than on uninfected dogs. However, the fecundity of P. perniciosus fed on infected dogs was adversely impacted compared to uninfected dogs by lowering the number of laid eggs. Phlebotomus perfiliewi, the second most abundant sand fly species in the field site and a competent vector of L. infantum had similar trends of attractivity as P. perniciosus toward infected dogs under field conditions.

Conclusions
The results strongly suggest that L. infantum causes physiological changes in the reservoir host which lead to the host becoming more attractive to both male and female P. perniciosus. These changes are likely to improve the chance of successful transmission because of increased contact with infected hosts and therefore, infected dogs should be particularly targeted in the control of zoonotic visceral leishmaniasis in North Africa.
High sedation needs of critically ill COVID-19 ARDS patients—A monocentric observational study
Authors: Flinspach Armin Niklas , Booke Hendrik , Zacharowski Kai , Balaban Ümniye , Herrmann Eva , Adam Elisabeth Hannah 
Published: July 2021

Background
Therapy of severely affected coronavirus patient, requiring intubation and sedation is still challenging. Recently, difficulties in sedating these patients have been discussed. This study aims to describe sedation practices in patients with 2019 coronavirus disease (COVID-19)-induced acute respiratory distress syndrome (ARDS).

Methods
We performed a retrospective monocentric analysis of sedation regimens in critically ill intubated patients with respiratory failure who required sedation in our mixed 32-bed university intensive care unit. All mechanically ventilated adults with COVID-19-induced ARDS requiring continuously infused sedative therapy admitted between April 4, 2020, and June 30, 2020 were included. We recorded demographic data, sedative dosages, prone positioning, sedation levels and duration. Descriptive data analysis was performed; for additional analysis, a logistic regression with mixed effect was used.

Results
In total, 56 patients (mean age 67 (±14) years) were included. The mean observed sedation period was 224 (±139) hours. To achieve the prescribed sedation level, we observed the need for two or three sedatives in 48.7% and 12.8% of the cases, respectively. In cases with a triple sedation regimen, the combination of clonidine, esketamine and midazolam was observed in most cases (75.7%). Analgesia was achieved using sufentanil in 98.6% of the cases. The analysis showed that the majority of COVID-19 patients required an unusually high sedation dose compared to those available in the literature.

Conclusion
The global pandemic continues to affect patients severely requiring ventilation and sedation, but optimal sedation strategies are still lacking. The findings of our observation suggest unusual high dosages of sedatives in mechanically ventilated patients with COVID-19. Prescribed sedation levels appear to be achievable only with several combinations of sedatives in most critically ill patients suffering from COVID-19-induced ARDS and a potential association to the often required sophisticated critical care including prone positioning and ECMO treatment seems conceivable.
Astrometry and photometry of digitized plates of Baldone Schmidt telescope
Authors: Eglitis Ilgmars , Andruk Vitaly 
Published: July 2021

Abstract
During the 40-year photographic period of astronomical observations, the Baldone Astrophysical Observatory has accumulated more than 22,000 direct and 2,500 spectral images. In 2018, the digitization of direct astrophoto images with a resolution of 1200 dpi was completed. A processing methodology for obtaining the equatorial coordinates and photometric characteristics of the objects recorded in digitized astronegatives using the LINUX/MIDAS/ROMAFOT environment has been developed at the Main Astronomical Observatory of the National Academy of Sciences of Ukraine. Program package with success already works in seven observatories. A description of the operation of this program complex in stages and analysis of the obtained results is given. The steps describe the astrometric and photometric reduction process of digital records, as well as the reduction of the obtained instrumental magnitudes to the Johnson UBVR photometric system. The methodology of characteristic curve construction in the case of one exposure is described in detail. From all digitized astrophotoplates to date Approximately 2200 V film negatives, 300 U plates and several R, B plates were processed. As a result, catalogs of the positions and magnitudes of Pluto, 1848 asteroids and comets were obtained. 31 new positions were recorded in the VizieR Pluto catalog VI/155. It was found that the root-mean-square errors of the reduction of the measured coordinates to the equatorial coordinate system of the Tycho-2 catalog have values σ
RA

,

DEC
= 0.1-0.2”, and the root-mean-square errors of the reduction of instrumental photometric quantities m to the Johnson system of stellar UBVR-values are also in within σ
UBVR
= 0.1 − 0.2
m
.
A polar dual to the momentum of toric Fano manifolds
Authors: Sano Yuji 
Published: July 2021

Abstract
We introduce an invariant on the Fano polytope of a toric Fano manifold as a polar dual counterpart to the momentum of its polar dual polytope. Moreover, we prove that if the momentum of the polar dual polytope is equal to zero, then the dual invariant on a Fano polytope vanishes.
Modeling of lime production process using artificial neural network
Authors: Daeichian Abolghasem , Shahramfar Rana , Heidari Elham 
Published: July 2021

Abstract
Lime is a significant material in many industrial processes, including steelmaking by blast furnace. Lime production through rotary kilns is a standard method in industries, yet it has depreciation, high energy consumption, and environmental pollution. A model of the lime production process can help to not only increase our knowledge and awareness but also can help reduce its disadvantages. This paper presents a black-box model by Artificial Neural Network (ANN) for the lime production process considering pre-heater, rotary kiln, and cooler parameters. To this end, actual data are collected from Zobahan Isfahan Steel Company, Iran, which consists of 746 data obtained in a duration of one year. The proposed model considers 23 input variables, predicting the amount of produced lime as an output variable. The ANN parameters such as number of hidden layers, number of neurons in each layer, activation functions, and training algorithm are optimized. Then, the sensitivity of the optimum model to the input variables is investigated. Top-three input variables are selected on the basis of one-group sensitivity analysis and their interactions are studied. Finally, an ANN model is developed considering the top-three most effective input variables. The mean square error of the proposed models with 23 and 3 inputs are equal to 0.000693 and 0.004061, respectively, which shows a high prediction capability of the two proposed models.
Revealing ethnographic mediations through reflexive writing: A collaborative exploration of tarot and astrology as a not-knowing approach
Authors: Wiesner Adam , Cornejo-Valle Mónica 
Published: July 2021

Abstract
In order to develop a collaborative experience of reflexive writing, this article explores the ethnographic process through two communication devices used by the authors in their respective fieldwork: tarot readings and evolutionary astrology. Reflecting on their distinct (if not opposing) backgrounds, the authors explore and interpret how their different backgrounds and conversational devices shape their ethnographic experience as a process of revealing the unknown, following the not-knowing approach (Anderson, 1997). The dialogic exchange also reveals how the not-knowing approach affects the collaborative aspect of the reflexive writing experience.
The closer we are, The harder it gets
Authors: Vrzgulová Monika 
Published: July 2021

Abstract
For the researcher, long-term qualitative investigation of a given subject matter represents an opportunity to acquire comprehensive knowledge of that subject matter in all of its dynamism and complexity. The author of this paper has been carrying out such research among Holocaust survivors, mainly employing the oral history method. This paper is an impressionistic story, a genre not commonly found in Slovak ethnological literature. It constitutes a first attempt to revisit material emerging from years of collaborative investigation with one particular female survivor. The paper alternates between reflections of selected situations and interpretations of events and processes which resulted from the research partner’s activities between 1995 and 2015.