bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Non-Ergodic Ground-Motion Model of Fourier Amplitude Spectra for France
Authors: Sung Chih-Hsuan , Abrahamson Norman , Kuehn Nicolas M. , Traversa Paola , Zentner Irmela 
Published: August 2021

Abstract
We used an ergodic ground-motion model (GMM) of California of Bayless and Abrahamson (Bull Seismol Soc Am 109(5):2088–2105, 2019) as a backbone model and incorporated the varying-coefficient model (VCM), with a modification for anisotropic path effects, to develop a new non-ergodic GMM for France based on the French RESIF data set (1996-2016). Most of the earthquakes in this database have small-to-moderate magnitudes (M2.0 – M5.2). We developed the GMM for the smoothed effective amplitude spectrum (EAS) rather than for elastic spectral acceleration because it allows the use of small magnitude data to constrain linear effects of the path and site without the complication of the scaling being affected by differences in the response spectral shape. For the VCM, the coefficients of GMM can vary by geographical location and they are estimated using Gaussian-process regression. There is a separate set of coefficients for each source and site coordinate, including both the mean coefficients and the epistemic uncertainty in the coefficients. We further modify the anelastic attenuation term of a GMM by the cell-specific approach of Kuehn et al. (Bull Seismol Soc Am 109 (2): 575–585, 2019) to allow for azimuth-dependent attenuation for each source which reduces the standard deviation of the residuals at long distances. As an example, we compute the 5Hz seismic hazard for two sites using the non-ergodic EAS GMM. At the 1 10-4 annual frequency of exceedance hazard level, there can be a large difference between the ergodic hazard and the non-ergodic hazard if the site is close to the available data. The combination of the non-ergodic median ground motion and the reduced aleatory variability can have large implications for seismic-hazard estimation for long return periods. For some sites, the estimated hazard will increase and for other sites the estimated hazard will decrease compared to the traditional ergodic GMM approach. Due to the skewed distribution of the epistemic uncertainty of the hazard, more of the sites will see a decrease in the mean hazard mean hazard at the 1 10-4 hazard level than will see an increase as a result of using the non-ergodic GMM.
Identification of Groundwater Potential Zones using Geospatial Techniques in Palar River Basin, Tamil Nadu, India
Authors: NARAYANAN MANJUNATHAN , VENUGOPAL THIRUKUMARAN 
Published: August 2021

Abstract
The present research work is aimed to identify the groundwater potential zones in the Palar River Basin (PRB). The Auto Regressive Integrated Moving Average (ARIMA) model, and geospatial techniques were used to determine the Groundwater Potential Zone (GPZ). Time series analysis is commonly used in a broad range of scientific applications including hydrology, metrology, geo-statistics, engineering and environmental management fields. The geospatial historical data of rainfall and water level recorded at yearly intervals for 14 years (2005 to 2018) was used to identify the fluctuation of water level with respect to rainfall with lower and upper confidence levels and eventually leads to identify the spatial variation of the groundwater potential zones. The ARIMA model evolved from analysis was further classified into Four types of goodness of fits namely excellent fit, good fit, poor fit, and no fit. The spatial variation of groundwater potential occurrence and behaviour of the region is controlled by geology, lineament, geomorphology and drainage. These layers have been integrated with the ArcGIS platform for generating Groundwater Potential Zone (GPZ) maps. The validation of the result shows that Excellent fits 40 wells (12.82%), good fits 108 wells (34.62%), poor fits 58 wells (16.66%), and no fits 106 wells (33.97%), the study area good groundwater potential zones approximately 47.44%. This research suggests that a good groundwater potential zone occurs in patches of the southern and eastern parts of the study area.
Genomic and RNA-Seq Profiling of Patients with Heart Failure Identified Alterations in Phosphorylation and Immune Signaling Pathways
Authors: Zhang Shikuan , Li Xin , Xu Xiang , Wei Qingxia , Li Hanlu , Liu Tong , Liu Chunlei L. 
Published: August 2021

Abstract
Background: Heart failure (HF) is a complex pathophysiological state in which the delivery of blood and nutrients to the tissues is inadequate. It is rarely curable and often associated with poor prognosis. The current study aimed to analyze the exomic and RNA-Seq data of patients with HF to identify the key altered pathways. Methods: Heart failure participants were recruited, and whole blood samples were collected. The samples were used for whole exome sequencing and RNA-Seq analysis. Gene expression and RNA-Seq results were verified by Gene chips and RT-PCRResults: We report a dysregulation of phosphorylation and immune signaling in patients with HF both by exomic and RNA-Seq data. We identified mutations in TITIN,OBSCURIN, NOD2, CDH2, MAP3K5, and SLC17A4 to be associated with HF by exomic analysis. And certain genes, S100A12, S100A8, S100A9, PFDN5, and TMCC2, were found upregulated in patients with HF by RNA-Seq. Conlcusion: Our results demonstrated the overall disruption of key phosphorylation and immune signaling pathways in patients with HF.
Applications of CRISPR/Cas Gene-Editing Technology in Fungi
Authors: Liao Binyou , Cheng Lei , Zhou Yujie , Shi Yangyang , Ye Xingchen , Liao Min , Zhou Ziyi , Zhou Xuedong , Ren Biao 
Published: August 2021

Abstract
Genome editing technology develop fast in recent years. The traditional gene-editing methods, including homologous recombination, zinc finger endonuclease, and transcription activator-like effector nuclease and so on, which have greatly promoted the research of genetics and molecular biology, have gradually showed their limitations such as low efficiency, high error rate, and complex design. In 2012,a new gene-editing technology, the CRISPR/Cas9 system, was setup based on the research of the immune responses to viruses from archaea and bacteria. Due to its advantages of high target efficiency, simple primer design, and wide application, CRISPR/Cas9 system, whose developers are awared the Nobel Prize in Chemistry this year, has become the dominant genomic editing technology in global academia and some pharmaceuticals. Here we briefly introduce the CRISPR/Cas system and its main applications in yeast, filamentous fungi and macrofungi, including single nucleotide, polygene and polyploid editing, yeast chromosome construction, yeast genome and yeast library construction, CRISPRa/CRISPRi-mediated, CRISPR platform of non-traditional yeast and regulation of metabolic pathway, to highlight the possible applications on fungal infection treatment and to promote the transformation and application of the CRISPR/Cas system in fungi.
Photocatalytic Removal of Toluene with CdIn2S4/CNFs as Catalyst: Effect of Ozone Addition
Authors: Liu Run Yu , Trinh Minh Man , Chang Moo-Been 
Published: August 2021

Abstract
CdIn2S4 (CIS) has attracted much attention in the photocatalysis research field due to its structural stability and photoelectric properties. However, it's difficult to recycle when after usage, so application of CIS photocatalysis in removing volatile organic compounds (VOCs) is still limited and the literature on applying carbon nanofibers (CNFs) as electron acceptor is scarce. In this study, a novel CIS/CNFs composite was synthesized via a simple hydrothermal method. X-ray diffraction (XRD), Scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS) were applied to characterize the structure, microtopography and composition of CIS/CNFs photocatalyst prepared. The results showed that CNFs with the size of about 300 nm were favorable connected with CIS to form 3D conductive network and CIS particles with the average size of 100 nm grew onto the surface of CNFs uniformly. Results of photocatalytic degradation tests indicate that under visible light irradiation, degradation of toluene reached the optimal level of 86% as the CIS doped with 3% CNFs. It proved that the composite material prepared had an excellent photocatalytic recycle efficiency via repeated experiments. Furthermore, 95% removal efficiency was achieved as 200 ppm ozone was added into the system and mineralization rate are also improved. Derived from the intermediates detected, possible pathways of toluene degradation were proposed. Hence, this study presents a new method to synthesize photocatalyst with visible-light driven ozone-enhanced photocatalysis process toward indoor air pollutants removal VOCs.
Wind Energy And CO2 Emissions: AMG Estimations For Selected Countries
Authors: Güney Taner , Üstündağ Emrah 
Published: August 2021

Abstract
This study aims to analyze the relationship between wind energy consumption, coal energy consumption, globalization, economic growth and carbon emissions in a selected country group. This analysis was made with the data of 37 countries for the period 2000-2019. In order to examine the long-term relationship between the variables, the AMG method, which makes an estimation by considering the cross-sectional dependence and slope homogeneity, was used in the study. According to the long-term coefficient estimates of the cointegrated variables, wind energy consumption has a statistically significant and negative effect on carbon emissions in the long run. A 1% increase in wind energy consumption reduces carbon emissions by 0.018%. On the other hand, the globalization variable has a statistically significant and positive effect on carbon emissions in the long run. A 1% increase in globalization increases carbon emissions by 0.107%. These findings show the importance of wind energy consumption in reducing carbon emissions. For this reason, policies should be produced to increase wind energy consumption globally and necessary incentives should be provided.
How Effective Is Traffic and Production Restriction for Air Pollution? Evidence From a Quasi-natural Experiment in China
Authors: Chen Yiqing , Wang Deyun , Elamraoui Adnen , Guo Haixiang 
Published: August 2021

Abstract
Air pollution seriously affects human health. The traffic and production restriction is widely used for controlling heavy air pollution. However, the effectiveness of these two policies has not been scientifically verified through a city-level study. COVID-19 pandemic caused lockdowns in many cities, which makes it possible to verify the effectiveness of these two policies. Taken Wuhan as the study area, this study firstly verifies the existence of lockdown effect on air pollution and analyzes the evolution rule of six air pollutants (PM2.5, PM10, NO2, SO2, CO and O3) using statistical methods. Then the structural break points in six air pollutants are detected with the regression discontinuity design model. Because Spring Festival overlapping COVID-19 may also affect the air pollution, in order to avoid the disturbance of Spring Festival on the results, the Spring Festival effect is also validated. The results illustrate that the effects of traffic and production restriction on six air pollutants are obviously different, in which the concentrations of PM2.5, PM10 and NO2 decrease significantly, while traffic and production restriction has no apparent effects on SO2, CO and O3. Moreover, the structural break points are verified in the four air pollutants (PM2.5, PM10, NO2 and CO), and the structural break points are caused by lockdown instead of Spring Festival. This study revealed how the traffic and production restriction affected the air pollution at a city level, and provided strong implementation basis to the air pollution control policy.
Efficacy of Chinese Herbal Medicine Jiangniaosuan Formula for Treatment of Hyperuricemia: Study Protocol For A Double-Blinded Non-Inferiority Randomized Controlled Clinical Trial
Authors: Guo Yafang , Lu Hong , Gan Jing , Li Dongdong , Gao Jiandong , Zhang Changming 
Published: August 2021

Abstract
Background: Jiangniaosuan formula (JNSF) is commonly used in China for treating hyperuricemia, but there is little research-based evidence to support its use. This randomized controlled trial aims to assess the efficacy and safety of JNSF.Methods: A total of 72 patients with hyperuricemia will be selected and randomly assigned in a ratio of 1:2 to receive either Western medicine i.e., febuxostat 40 mg (WG group; n = 24) or Chinese herbal medicine group, i.e., Jiangniaosuan formula + febuxostat 20 mg (WJNSG; n = 48). After 12 weeks, the WJNSG will be randomly divided into two groups of 24 patients each; one group (WJNSG; n = 24)still will receive febuxostat 20 mg + Jiangniaosuan formula and the other group(JNSG; n = 24) will continue to receive Jiangniaosuan formula+Placebo. Participants will be followed up at 4-week intervals. The primary outcome will be the change in serum uric acid level, and the secondary outcome will be the change in Traditional Chinese Medicine (TCM) syndrome scores. Serum creatinine, blood glucose, and insulin levels will also be measured.Discussion: We hypothesize that patients with hyperuricemia will benefit from JNSF. This study will provide evidence-based recommendations for clinicians.Dissemination: The results will be published in a peer-reviewed journal and disseminated by academic conferences.Trial registration : This trial is registered with ClinicalTrials.gov, number ChiCTR2000041083. 22 Registered on 3 May 2021.
Prediction of BRCA Gene Mutation Status in Epithelial Ovarian Cancer by Radiomics Models based on 2D and 3D CT Images
Authors: liu mingzhu , ge yaqiong , li mengru , wei wei 
Published: August 2021

Abstract
Background The objective of this study is to explore the value of two-dimensional (2D) and three-dimensional (3D) radiomics models based on enhanced computed tomography(CT) images in predicting BRCA gene mutations in patients with epithelial ovarian cancer. Methods A retrospective analysis of the clinical and imaging data of 122 patients with ovarian cancer confirmed by surgery and pathology and on which genetic testing was performed. Radiomics features were extracted from the 2D and 3D regions of interest of the patients’ primary tumor lesions, and features were selected in the training set using the maximum correlation and minimum redundancy method. Then, the best features were selected through Lasso 10-fold cross-validation. Feature subsets were used to establish a radiomics model. We used area under the receiver operating characteristic curve analysis to evaluate the model’s performance and then used the model’s decision curve to evaluate its clinical validity. Results On the validation set, the area under the curve values of the 2D, 3D, and 2D+3D combined models was 0.78 (0.61–0.96), 0.75 (0.55–0.92), and 0.82 (0.61–0.96), respectively. However, the DeLong test P values between the three pairs of models were all >0.05. The decision curve analysis showed that the radiomics model had a high net benefit across all high-risk threshold probabilities. Conclusions The three radiomics models can predict the BRCA gene mutation in ovarian cancer, and there were no statistically significant differences between the three models’ prediction performance.
Factors Associated With Relief Overdemanding in The Disaster Response Phase: A Qualitative Content Analysis
Authors: Bathaei Seyed Ahmad , Khankeh Hamid Reza 
Published: August 2021

Abstract
Demand for relief increases after disasters. Some research suggests that the number of relief supplies required to satisfy the relief demanding after disasters is significantly higher than preliminary estimates, especially in low and lower-middle-income countries. So, this study was aimed to explore the reasons for relief overdemanding in the disaster response phase. In this qualitative content analysis study the managers of the National Disaster Management Organization (NDMO), the Iranian Medical Emergency and Accident Management Center, Tehran Disaster Mitigation and Management Organization (TDMMO) and the Iranian Red Crescent Society (IRCS) were purposively sampled and invited to interview. The unstructured face-to-face interviews were recorded, transcribed, and analyzed using "constant comparison" and "microanalysis" methods. 21 agreed to participate and were interviewed. The interviews uncovered affected people-level factors such as the react to fear and anxiety and the unsatisfied demand due to improper distribution of facilities and crisis managers-level issues (e.g. facing people's dissatisfaction, incorrect or insufficient information and considering disaster as the opportunity to raise resources) as well as officials-level determinants (e.g. advertising and excitement, the partisanship of officials and low confidence on accident managers). Several factors influencing the relief overdemanding exist in disaster management in Iran. Strengthening local management when responding to disasters and conducting efficient disaster need assessment can reduce relief overdemanding and vastly prevent wasting surplus resources in the affected area.
Ethnobotanical Study of Medicinal Plants Used To Treat Livestock Ailments In Ensaro District, North Shewa Zone, Amhara Region, Ethiopia
Authors: Asfaw Asaye , Lulekal Ermias , Bekele Tamrat , Debella Asfaw , Debebe Eyob , Ssisay Bihonegn 
Published: August 2021

Abstract
Introduction: In Ethiopia, the majority of animal owners throughout the country depend on traditional healthcare practices to manage their animals’ health. Ethnoveterinary practices play significantly greater roles in livestock health care as an alternative or integral part of modern veterinary practices. This is because traditional medicines have remained the most economically affordable and easily available form of therapies for resource-poor communities. Even although, ethnoveterinary medicine is the most important and has higher acceptance and trust by the community in Ethiopia, ethnoveterinary medicinal plants and associated indigenous practices are not adequately documented. This study aimed to identify and document ethnoveterinary medicinal plants with their associated indigenous practices along with the habitats of these plants in Ensaro district.Methods: This ethnobotanical survey included 389 informants (283 males and 106 females) from all 14 kebeles of Ensaro district, which is the smallest administrative unit in Amhara Regional State's North Shewa Zone. Systematic random and intentional sampling techniques have been used to obtain representative informants. Ethnobotanical data were collected during the 13th of February 2019 and the 26th of October 2020 through Semi-structured interviews, field observation, a guided field walk, and focus group discussions.Results: We identified and recorded 44 medicinal plants belonging to 43 genera and 28 families that are used in Ensaro district to manage livestock diseases. The analysis of collected information from informants showed that shrubs constituted the highest number of species, leaves were the most highly harvested parts for the preparation of remedies and oral administration was the main route to apply medicines to treat internal diseases of livestock. Conclusion: In general, the findings of this study revealed diverse ethnoveterinary medicinal plants and associated indigenous practices about their use in the Ensaro District. The majority of farmers trust traditional ethnoveterinary medicines due to their higher efficacy, lower price, and easy availability. Data from this study can be used to preserve important medicinal plants for sustainable utilization and drug formulation.
Factors Associated With The Relapse In Ponseti Treated Congenital Club Foot
Authors: Hu Wei , Ke Baoyi , Xiao Niansu , Li Sen , Li Cheng , Lai Xingming , Huang Xinyu 
Published: August 2021

Abstract
Objectives. We retrospectively investigated the clinical materials to seek the factors that lead to relapse after using the Ponseti method.Methods. We retrospectively reviewed all children with congenital club foot treated with the Ponseti method in our hospital from June 2008 to June 2013. The data included the following factors: age, gender, initial Pinari score, number of casts, number of feet (unilateral or bilateral), age at the first casting, age of mother, tenotomy, walking age, and compliance with using bracing. All investigations were conducted in conformity with ethical standards. This study was approved by Guilin Peoples’ Hospital Ethics Committee.Results. In this study, there were 148 cases with 164 feet in total that underwent the Ponseti method. Of them, 64 children presented with left side, 58 with right side, and 26 with bilateral cases. This study included 75 males and 73 females; sex did not affect the outcomes. The mean age of the first casting was 2.50±2.15 months. The average initial Pirani score was 4.98±1.33, 2 and the average number of casts was 5.71±2.28 times. The mean age of mothers at birth was 25.81±2.38 years old. The walking age of children was at a mean of 14.83±1.18 months. Forty-nine cases could not tolerate using braces, namely the rate of noncompliance in this study was 33.1%. Tenotomy was performed on 113 feet (76.4%). The average follow–up period was 7.27±1.29 years (from 5 to 10 years). The rate of relapse was 21.6% (32 cases) at the end of the follow-up. The rate of relapse in the noncompliance with using bracing group was significantly higher compared to the compliance group.Conclusion. The initial Pirani score, compliance with the foot abduction brace and the age at the first casting are three independent factors for relapse in clubfoot.
The Effects of Magnetic Treatment On Seedling Growth, Nitrogen Metabolism, And Mineral Nutrient Contents In Populus×Euramericana 'Neva' Under Cadmium Stress
Authors: Liu Xiumei , Ma Fengyun , Wang Lu , Zhu Hong , Meng Shiyuan , Bi Sisheng , Guo Jianyao , Wang Huatian 
Published: August 2021

Abstract
Background: The potted experiment was carried out to investigate the mechanism of nutrient metabolism and seedling growth caused by magnetic treatment (MT) following exposure to cadmium (Cd) stress. One-year-old seedlings of Populus×euramericana 'Neva' were treated with different Cd(NO3)2 solutions for 30 days. Properties of seedling growth and root morphology were promoted by MT under Cd exposure.Results: Contents of ammonium (NH4+-N), nitrate (NO3--N), and total nitrogen (TN) in leaves, also NH4+-N and TN in roots, were increased by MT combined with Cd-stress, although NO3--N content was decreased. Activities of nitrate reductase (NR), nitrite reductase (NiR), glutathione reductase (GR), and glutamate synthase (GOGAT) in leaves and activities of NR, GS and GOGAT in roots were stimulated by MT; conversely, NiR activity in roots was inhibited. MT improved the synthesis of cysteine (Cys) and glutamine (Gln) in leaves and reduced the contents of glutamic acid (Glu) and glycine (Gly), while contents of Cys, Glu, Gln, and Gly were increased in roots. (4) The contents of Ca, Mg, Fe, Mn, Zn and Cu were increased by MT under Cd stress in leaves, whereas content of K was reduced. In roots, contents of K, Ca, and Fe were increased by MT under Cd-stress, but the contents of Na, Mg, Mn, Zn, and Cu were decreased.Conclusions: Magnetization could regulate the uptake of mineral nutrients by roots and translocation from the roots to aboveground parts by affecting the root morphology. MT could also improve nitrogen assimilation and the synthesis of free amino acids by stimulating the activities of key enzymes.