bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANGKA KEJADIAN DIABETES MELLITUS PADA LANSIA MIDDLE AGE DI MASA PANDEMI COVID-19
Authors: Kurdi Fahruddin , Abidin Zainal , Surya Vespan Candra , Anggraeni Nabila Cindy , Alyani Diwali Sukma , Riskiyanti Villyana 
Published: October 2021

Pendahuluan : Lanjut usia merupakan seseorang dengan kriteria usia 60 tahun ke atas dan mengalami proses penuaan yang berlangsung sepanjang hidup, mengakibatkan perubahan kumulatif dan turunnya daya tahan tubuh dalam menghadapi rangsangan dari dalam dan luar tubuh. Pada era pandemi saat ini, kelompok lanjut usia merupakan kelompok yang paling beresiko mengalami morbiditas dan mortalitas akibat penyakit COVID-19 dengan berbagai komorbiditas salah satu diantaranya Diabetes Mellitus. Pencegahan penularan melalui upaya promotif dan preventif kepada kelompok lansia sangat penting dilakukan, di tingkat keluarga, masyarakat dan fasilitas kesehatan. Serta antisipasi dampak dari kebijakan pembatasan sosial seperti kesehatan mental dan kognitif, meningkatnya jumlah serta komplikasi penyakit kronik, dan jumlah lanjut usia yang mengalami ketergantungan karena akses terhadap layanan kesehatan yang terhambat. Tujuan dari penelitian ini adalah untuk mengetahui gambaran kejadian Diabetes Mellitus pada lanjut usia di masa pandemi COVID-19 di wilayah kerja Puskesmas Pakusari Kabupaten Jember pada tahun 2020.
Metodologi : Desain penelitian ini adalah kuantitatif deskriptif bersifat retrospektif dengan melakukan observasi terhadap data sekunder lansia selama tahun 2020 yakni berupa database yang diambil dari Puskesmas Pakusari Kabupaten Jember melalui koordinasi dengan penanggung jawab lansia.
Hasil : Hasil penelitian menunjukkan distribusi data karakteristik lanjut usia (lansia) dan diketahui bahwa kejadian penyakit Diabetes Mellitus (DM) banyak terjadi pada rentang usia 45- 59 tahun atau pralansia yakni sebanyak 357 (68%) dan sebagian besar yang mengalami Diabetes Mellitus (DM) berjenis kelamin perempuan dengan jumlah 281 (54%).
Diskusi/Pembahasan : Pihak Puskesmas Pakusari Kabupaten Jember terutama penanggung jawab lansia dan petugas Posbindu PTM dapat menjangkau para lanjut usia (lansia) dengan Diabetes Mellitus (DM) melalui telepon atau layanan kesehatan jarak jauh, menyiapkan persediaan obat dan persediaan kritis minimal 2 minggu di rumah, edukasi kepada lansia terkait gaya hidup, kunjungan rumah secara berkala terutama untuk lanjut usia (lansia) yang tidak pernah menghadiri jadwal kontrol rutin.
Students’ Problems in Semantic Meaning Analysis of Literary Works in English Handbooks
Authors: Syarifuddin Salmia , Hasyim Irmawaty 
Published: October 2021

English handbooks used in High schools fill with literary works. It is either in poem, prose, or drama. These literary works are human’s creatures both in spoken and written language which fills with implicit meaning beneath the stylistic language used in that literary works. Besides, semantics is a branch of linguistics that studies meaning. This study aimed to find out problems faced by students in the analysis of the semantics meaning of literary works found in English handbooks. This study applied the qualitative descriptive method. The result showed that the problems faced by students lied beneath the determination of semantics meanings and their types found in words, phrases, clauses, and sentences in literary works.
Investigating The Correlation Between Classroom Management and Student Interests in EFL Environment
Authors: Noer Muli Umiaty , Utami Sri Suci , Abdollah Abdollah 
Published: October 2021

The research aimed were to find out the correlation between classroom management and student’s interest. This research uses quantitative with survey method that apply correlation technique there are two variable in this research, namely dependent variable and independent variable. The independent variable is classroom management while dependent variable is students interest the population of this research as two classes of ABA UMI year 2016-2017. The samples of this research are 20 respondents taken through purposive sampling technique . in analysis the data of this research, the write used ( Correlation ). The findings of this study shows that there is any significant correlation between classroom management and student’s interest at the second grade of social class ABA UMI. This is proved by the value of the pearson product moment is -025 it means the correlation. And classroom management and student’s interest is weak. And correlation classroom management has an important role in learning process because if there is in classroom management the student’s will not be interest in learning process.
The Study of Khalawatiyah Tradition about the Barazanji
Authors: Rusdiah Rusdiah , Hudriati Andi , S Rahmadani 
Published: October 2021

The study aims (1) to know the benefits of the Barazanji carried out by the Khalawatiyah tradition of the people in Parangloe society, and (2) To know the message of Khalawatiyah tradition about the Barazanji for the Parangloe society. The research designed in this study was qualitative research. The data were processed based on observation, interviews, and documentation. The writer does interviews with informants. The informants that are used in this research are the society of Khalawatiyah’s tarekat for finding the benefits and the message of Khalawatiyah tradition about the Barazanji for the parangloe society.
The writer’s findings indicated that the benefits of the Barazanji carried out by the Khalawatiyah tradition of the people in Parangloe society are the Barazanji as inner satisfaction, the barazanji as giving bless a ceremony, the Barazanji as indicted media, the Barazanji for getting a reward, and Brazanji gives information for people to know and preserve the life history of the prophet Muhammad saw. The finding also indicated that the message of Khalawatiyah tradition about the Barazanji for the Parangloe society is the first the people must know the personality of the prophet Muhammad saw and hope to emulate all of about prophet Muhammad saw and the second people always sent shalawat to Muhammad saw.
Investigating the Role of International Phonetic Alphabet to Enhance Highschool Students’ Pronunciation Skill
Authors: Chuzaimah Chuzaimah , Fadli Falih 
Published: October 2021

International Phonetic Alphabet (IPA) has been used to provide a unique symbol for each distinctive sound in a language. The IPA has been widely utilized by linguists and dictionaries with modifications for easier identification. This study focuses on how IPA supports Indonesian EFL learners with their pronunciation practice particularly in senior high school context. The present study is qualitative literary research. First, the researcher collected the data from the questionnaire, second, the researcher identified them and make it into conclusion. The result of the analysis showed that students gave their positive perspective in using the IPA symbols as they believed it could enhance their oral skills and technique for learning pronunciation. Although IPA symbols were regarded as useful and easier to learn, several students thought positively of using the phonetic symbol in their learning, most of them felt it is difficult, since the phonetic symbols each had distinctive symbols resulting in students confused to remember and comprehend. This study implies that while the learning curve is high, students were quite motivated to learn English pronunciation through IPA.
Hubungan Tingkat Pengetahuan Perawat dengan Penerapan Patient Safety di Ruang Rawat Inap Rumah Sakit Dr. Tadjuddin Chalid Kota Makassar
Authors: Jamila Nadhia Widyanthi , Sumiaty  , Septiyanti  
Published: October 2021

Rumah Sakit sebagai tempat pelayanan kesehatan di perlukan mutu pelayanan kejadian yang tidak diinginkan seperti kesalahan obat, pasien cedera, dan kesalahan prosedur tidak terjadi. Jika hal-hal ini terjadi maka akan mengakibatkan kerugian pada pasien dan juga pada rumah sakit. Tujuan penelitian ini adalah untuk menganalisis hubungan Tingkat Pengetahuan Perawat dengan Penerapan Patient Safety Di Ruang rawat inap rumah sakit Dr. Tadjuddin Chalid Kota Makassar Tahun 2020. Jenis penelitian adalah kuantitatif dengan pendekatan cross sectional study. Sampel berjumlah 57 responden tapi yang kembali dan terisi dengan benar hanya 40 kuesioner, dengan 57 populasi dan 57 sampel diambil dengan cara total sampling. Data diperoleh menggunakan kuesioner. Analisis data dilakukan secara univariat dan bivariat menggunakan uji chi square.
Hasil penelitian menunjukkan bahwa pengetahuan perawat dengan penerapan patient safety kategori cukup sebanyak 37 orang (92,5%) dan yang menyatakan kurang sebanyak 3 orang (7,5%). Penerapan program patient safety kategori baik sebanyak 37 orang (92,5%) dan yang menyatakan kurang baik sebanyak 3 orang (7,5%). Berdasarkan uji statistik chi-square diperoleh nilai ρ = 0,00, nilai tersebut lebih kecil dari pada α=0,05 (p < dari nilai α=0,05) artinya ada hubungan yang signifikan antara Pengetahuan dengan penerapan pasient safety di Ruang rawat inap rumah sakit Dr. Tadjuddin Chalid Kota Makassar Tahun 2020. Dari hasil penelitian ini, dapat disimpulkan bahwa ada hubungan Pengetahuan dengan penerapan patient safety Di Ruang Rawat Inap RS. Dr. Tadjuddin Chalid Makassar Tahun 2020.
Perancangan Aplikasi Pendataan Keluarga Miskin dengan Menggunakan Metodologi Unified Approach
Authors: Fitriani Leni , Purnama Rifan Miptah 
Published: October 2021

Sistem informasi sangat diperlukan untuk dapat mendukung manusia dalam mengolah data dan menghasilkan sebuah informasi yang akurat. Sistem manual yang seharusnya sudah tergantikan dengan sistem informasi yang telah terkomputerisasi sudah banyak dilakukan pleh instansi pemerintah. Kendala yang dihadapi sekarang mengenai hal efisiensi waktu, pembuatan aplikasi dan proses dalam pendataan. Laporan bagian pendataan dan penginputan data yang sekarang masih dalam bentuk manual di tulis tangan hal ini bisa menyulitkan di dalam proses untuk pencarian data, serta data yang hilang. Pendataan untuk keluarga miskin ini sangat penting untuk dapat mengetahui siapa saja keluarga miskin yang nantinya akan mendapatkan bantuan dari pemerintah. Tujuan dalam penelitian ini untuk membuat aplikasi pendataan keluarga miskin di kelurahan maripari. Penelitian ini dilakukan dengan metode Unified Approach dengan tahapan analisis, desain dan programing. Hasil dalam penelitian ini diharapkan bisa menjadi alternatif untuk pemecahan permasalahan dalam pendataan keluarga miskin. Dengan dibuatnya aplikasi pendataan ini diharapkan dapat meminimalisir masalah yang sering terjadi pada sistem manual yang ada dan dapat membantu untuk menyelesaikan laporan untuk pendataan keluarga miskin.
Magnetic Agarose Microspheres/Hyaluronic Acid Hydrogel as a Trackable Bulking Agent for Vesicoureteral Reflux Treatment
Authors: Chen Hong , Wu Pan , Xu Hong , Wang Changchun 
Published: October 2021

Vesicoureteral reflux (VUR) is one of the most common congenital anomalies in the kidney and the urinary tract. Endoscopic subureteral injection of a bulking agent has become popular in VUR treatment due to its high success rates, few complications, and a straightforward procedure. In this study, a novel magnetic bulking agent was prepared by embedding Fe3O4 magnetic nanoparticles in cross-linked agarose microspheres with diameters of 80–250 μm and dispersing the magnetic microspheres in a hyaluronic acid hydrogel. The bulking agent has good biocompatibility and biosecurity validated by the tests of cytotoxicity, in vitro genotoxicity, animal irritation, skin sensitization, acute systemic toxicity, and pathological analysis after the injection of the bulking agent extract solution into healthy mice as well as injection of the bulking agent into VUR rabbits. The VUR rabbits were created by incising the roof of the intravesical ureter to enlarge the ureteral orifice. The success rate of the bulking agent in treating VUR rabbits using a subureteral transurethral injection technique was 67% (4/6) or 80% (4/5, excluding the unfinished rabbit), and no migrated particles were found in the organs of the rabbits. The transverse relaxation rate of the bulking agent was 104 mM−1s−1. After injection, the bulking agent was long-term trackable through magnetic resonance imaging that can help clinicians to inspect the VUR treatment effect. For the first time, this study demonstrates that the bulking agent with a long-term stable tracer is promising for endoscopic VUR treatment.
A Computer-Aided Diagnosis System and Thyroid Imaging Reporting and Data System for Dual Validation of Ultrasound-Guided Fine-Needle Aspiration of Indeterminate Thyroid Nodules
Authors: Liang Xiaowen , Huang Yingmin , Cai Yongyi , Liao Jianyi , Chen Zhiyi 
Published: October 2021

PurposeThe fully automatic AI-Sonic computer-aided design (CAD) system was employed for the detection and diagnosis of benign and malignant thyroid nodules. The aim of this study was to investigate the efficiency of the AI-Sonic CAD system with the use of a deep learning algorithm to improve the diagnostic accuracy of ultrasound-guided fine-needle aspiration (FNA).MethodsA total of 138 thyroid nodules were collected from 124 patients and diagnosed by an expert, a novice, and the Thyroid Imaging Reporting and Data System (TI-RADS). Diagnostic efficiency and feasibility were compared among the expert, novice, and CAD system. The application of the CAD system to enhance the diagnostic efficiency of novices was assessed. Moreover, with the experience of the expert as the gold standard, the values of features detected by the CAD system were also analyzed. The efficiency of FNA was compared among the expert, novice, and CAD system to determine whether the CAD system is helpful for the management of FNA.ResultIn total, 56 malignant and 82 benign thyroid nodules were collected from the 124 patients (mean age, 46.4 ± 12.1 years; range, 12–70 years). The diagnostic area under the curve of the CAD system, expert, and novice were 0.919, 0.891, and 0.877, respectively (p &lt; 0.05). In regard to feature detection, there was no significant differences in the margin and composition between the benign and malignant nodules (p &gt; 0.05), while echogenicity and the existence of echogenic foci were of great significance (p &lt; 0.05). For the recommendation of FNA, the results showed that the CAD system had better performance than the expert and novice (p &lt; 0.05).ConclusionsPrecise diagnosis and recommendation of FNA are continuing hot topics for thyroid nodules. The CAD system based on deep learning had better accuracy and feasibility for the diagnosis of thyroid nodules, and was useful to avoid unnecessary FNA. The CAD system is potentially an effective auxiliary approach for diagnosis and asymptomatic screening, especially in developing areas.
The Correlation Between Survival Benefit of Preoperative Radiotherapy and Pretreatment Carcinoembryonic Antigen Level in Locally Advanced Rectal Cancer
Authors: Wang Lei , Zhong Xiaohong , Lin Huaqin , Shao Lingdong , Chen Gang , Wu Junxin 
Published: October 2021

BackgroundPreoperative radiotherapy followed by radical surgery is the standard treatment for locally advanced rectal cancer; however, its long-term survival benefit remains controversial. This study aimed to determine the relationship between pretreatment carcinoembryonic antigen (CEA) levels and the long-term prognosis of preoperative radiotherapy in locally advanced rectal cancer (LARC) patients.MethodsData of LARC patients who underwent surgery between 2011 and 2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database, and patients were accordingly divided into surgery (S) group and radiotherapy followed by surgery (RT+S) group. The primary outcomes were cancer-specific survival (CSS) and cancer-specific mortality (CSM). CSS was evaluated using Kaplan-Meier analysis, while CSM was evaluated using a competitive risk model. Subgroup analysis was also conducted, which was stratified by pretreatment CEA levels.ResultsA total of 2,760 patients were eligible for this study, including 350 (12.7%) patients in the S group and 2,410 (87.3%) in the RT+S group. There were no significant differences in the CSS and CSM rates at 1, 3, and 4 years between the S and RT+S groups before and after PSM (all p &gt; 0.05). Pretreatment CEA levels were independently associated with CSS and CSM after adjusting for age, sex, stage, pathological factors, and treatment factors (all p &lt; 0.05). Subgroup analysis showed that preoperative radiotherapy would benefit patients with elevated CEA in terms of CSS and CSM (both p &lt; 0.05) but not those patients with normal CEA (both p &gt; 0.05). Further analysis showed that preoperative radiotherapy was an independent protective factor for CSS and CSM in patients with elevated CEA levels (both p &lt; 0.05).ConclusionsPretreatment CEA level may be considered a potential biomarker to screen LACR patients who would benefit from preoperative radiotherapy in terms of long-term prognosis.
Development and Validation of Prognostic Model in Transitional Bladder Cancer Based on Inflammatory Response-Associated Genes
Authors: Xie Zhiwen , Cai Jinming , Sun Wenlan , Hua Shan , Wang Xingjie , Li Anguo , Jiang Juntao 
Published: October 2021

BackgroundBladder cancer is a common malignant type in the world, and over 90% are transitional cell carcinoma. While the impact of inflammatory response on cancer progression has been reported, the role of inflammatory response-associated genes (IRAGs) in transitional bladder cancer still needs to be understood.MethodsIn this study, IRAGs were download from Molecular Signature Database (MSigDB). The transcriptional expression and matched clinicopathological data were separately obtained from public databases. The TCGA-BLCA cohort was used to identify the differentially expressed IRAGs, and prognostic IRAGs were filtrated by univariate survival analysis. The intersection between them was displayed by Venn diagram. Based on least absolute shrinkage and selection operator (LASSO) regression analysis method, the TCGA-BLCA cohort was used to construct a risk signature. Survival analysis was conducted to calculate the overall survival (OS) in TCGA and GSE13507 cohort between two groups. We then conducted univariate and multivariate survival analyses to identify independently significant indicators for prognosis. Relationships between the risk scores and age, grade, stage, immune cell infiltration, immune function, and drug sensitivity were demonstrated by correlation analysis. The expression level of prognostic genes in vivo and in vitro were determined by qRT-PCR assay.ResultsComparing with normal tissues, there were 49 differentially expressed IRAGs in cancer tissues, and 12 of them were markedly related to the prognosis in TCGA cohort for transitional bladder cancer patients. Based on LASSO regression analysis, a risk model consists of 10 IRAGs was established. Comparing with high-risk groups, survival analysis showed that patients in low-risk groups were more likely to have a better survival time in TCGA and GSE13507 cohorts. Besides, the accuracy of the model in predicting prognosis is acceptable, which is demonstrated by receiver operating characteristic curve (ROC) analysis. Age, stage, and risk scores variables were identified as the independently significant indicators for survival in transitional bladder cancer. Correlation analysis represented that the risk score was identified to be significantly related to the above variables except gender variable. Moreover, the expression level of prognostic genes in vivo and in vitro was markedly upregulated for transitional bladder cancer.ConclusionsA novel model based on the 10 IRAGs that can be used to predict survival time for transitional bladder cancer. In addition, this study may provide treatment strategies according to the drug sensitivity in the future.
Establishment and Validation of an Integrated Model to Predict Postoperative Recurrence in Patients With Atypical Meningioma
Authors: Chen Xiao-Yong , Chen Jin-Yuan , Huang Yin-Xing , Xu Jia-Heng , Sun Wei-Wei , Chen Yue- , Ding Chen-Yu , Wang Shuo-Bin , Wu Xi-Yue , Kang De-Zhi , You Hong-Hai , Lin Yuan-Xiang 
Published: October 2021

BackgroundThis study aims to establish an integrated model based on clinical, laboratory, radiological, and pathological factors to predict the postoperative recurrence of atypical meningioma (AM).Materials and MethodsA retrospective study of 183 patients with AM was conducted. Patients were randomly divided into a training cohort (n = 128) and an external validation cohort (n = 55). Univariable and multivariable Cox regression analyses, the least absolute shrinkage and selection operator (LASSO) regression analysis, time-dependent receiver operating characteristic (ROC) curve analysis, and evaluation of clinical usage were used to select variables for the final nomogram model.ResultsAfter multivariable Cox analysis, serum fibrinogen &gt;2.95 g/L (hazard ratio (HR), 2.43; 95% confidence interval (CI), 1.05–5.63;p = 0.039), tumor located in skull base (HR, 6.59; 95% CI, 2.46-17.68;p &lt; 0.001), Simpson grades III–IV (HR, 2.73; 95% CI, 1.01–7.34;p = 0.047), tumor diameter &gt;4.91 cm (HR, 7.10; 95% CI, 2.52–19.95;p &lt; 0.001), and mitotic level ≥4/high power field (HR, 2.80; 95% CI, 1.16–6.74;p = 0.021) were independently associated with AM recurrence. Mitotic level was excluded after LASSO analysis, and it did not improve the predictive performance and clinical usage of the model. Therefore, the other four factors were integrated into the nomogram model, which showed good discrimination abilities in training cohort (C-index, 0.822; 95% CI, 0.759–0.885) and validation cohort (C-index, 0.817; 95% CI, 0.716–0.918) and good match between the predicted and observed probability of recurrence-free survival.ConclusionOur study established an integrated model to predict the postoperative recurrence of AM.
Tacrolimus Intrapatient Variability After Switching From Immediate or Prolonged-Release to Extended-Release Formulation, After an Organ Transplantation
Authors: Del Bello Arnaud , Gaible Clotilde , Longlune Nathalie , Hebral Anne-Laure , Esposito Laure , Gandia Peggy , Kamar Nassim 
Published: October 2021

Background and Purpose: Several formulations of tacrolimus are available, but evidence of the benefit of changing to the most recent formulations is lacking. Tacrolimus intra-patient variability (tacrolimus IPV) is an emerging risk factor associated with poor graft outcomes after solid organ transplantations. Here, we examined the modifications of tacrolimus IPV after switching to a different formulation of tacrolimus.Experimental Approach: We identified 353 solid organ transplant recipients that were switched in our center from immediate-release (IR-tacrolimus) or prolonged-release tacrolimus (PR-tacrolimus) to extended-release, LCP-tacrolimus (LCP-tacrolimus). Among them, 54 patients underwent at least 3 available tacrolimus blood concentrations before and after the switch, allowing us to investigate tacrolimus IPV.Key Results: The switch was considered as a safe procedure since only four of the 353 patients presented a graft rejection after the switch, and no patient was hospitalized for tacrolimus overdose. The tacrolimus IPV estimated by the coefficient of variation (CV-IPV) was stable before and after the switch to LCP-tacrolimus (CV-IPV: 29.0% (IQR 25–75 (15.5; 38.5) before and 24.0% (15.8; 36.5) after the switch, p = 0.65).Conclusion and Implications: Switching from IR- or PR-tacrolimus to LCP-tacrolimus is a safe procedure. However, the CV-tacrolimus IPV was not impacted by the change of formulation.