bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-cigarette use and combustible tobacco cigarette smoking uptake among non-smokers, including relapse in former smokers: umbrella review, systematic review and meta-analysis
Authors: Baenziger Olivia Nina , Ford Laura , Yazidjoglou Amelia , Joshy Grace , Banks Emily 
Published: March 2021

ObjectiveTo review and summarise the current evidence on the uptake of combustible cigarette smoking following e-cigarette use in non-smokers—including never-smokers, people not currently smoking and past smokers—through an umbrella review, systematic review and meta-analysis.DesignUmbrella review, systematic review and meta-analysis.Data sourcesPubMed, Scopus, Web of Science, PsychINFO (Ovid), Medline (Ovid) and Wiley Cochrane Library up to April 2020.ResultsOf 6225 results, 25 studies of non-smokers—never, not current and former smokers—with a baseline measure of e-cigarette use and an outcome measure of combustible smoking uptake were included. All 25 studies found increased risk of smoking uptake with e-cigarette exposure, although magnitude varied substantially. Using a random-effects model, comparing e-cigarette users versus non-e-cigarette users, among never-smokers at baseline the OR for smoking initiation was 3.19 (95% CI 2.44 to 4.16, I2 85.7%) and among non-smokers at baseline the OR for current smoking was 3.14 (95% CI 1.93 to 5.11, I2 91.0%). Among former smokers, smoking relapse was higher in e-cigarette users versus non-users (OR=2.40, 95% CI 1.50 to 3.83, I2 12.3%).ConclusionsAcross multiple settings, non-smokers who use e-cigarettes are consistently more likely than those avoiding e-cigarettes to initiate combustible cigarette smoking and become current smokers. The magnitude of this risk varied, with an average of around three times the odds. Former smokers using e-cigarettes have over twice the odds of relapse as non-e-cigarettes users. This study is the first to our knowledge to review and pool data on the latter topic.PROSPERO registration numberCRD42020168596.
Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial
Authors: Ng Siew C , Xu Zhilu , Mak Joyce Wing Yan , Yang Keli , Liu Qin , Zuo Tao , Tang Whitney , Lau Louis , Lui Rashid N , Wong Sunny H , Tse Yee Kit , Li Amy Y L , Cheung Kitty , Ching Jessica Y L , Wong Vincent W S , Kong Alice P S , Ma Ronald C W , Chow Elaine Y K , Wong Simon K H , Ho Ivan Chak Hang , Chan Paul K S , Chan Francis K L 
Published: March 2021

ObjectiveThe impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM).DesignIn this double-blind, randomised, placebo-controlled trial, 61 obese subjects with T2DM were randomly assigned to three parallel groups: FMT plus lifestyle intervention (LSI), FMT alone, or sham transplantation plus LSI every 4 weeks for up to week 12. FMT solution was prepared from six healthy lean donors. Faecal metagenomic sequencing was performed at baseline, weeks 4, 16 and 24. The primary outcome was the proportion of subjects acquiring ≥20% of microbiota from lean donors at week 24.ResultsProportions of subjects acquiring ≥20% of lean-associated microbiota at week 24 were 100%, 88.2% and 22% in the FMT plus LSI, FMT alone, and sham plus LSI groups, respectively (p<0.0001). Repeated FMTs significantly increased the engraftment of lean-associated microbiota (p<0.05). FMT with or without LSI increased butyrate-producing bacteria. Combining LSI and FMT led to increase in Bifidobacterium and Lactobacillus compared with FMT alone (p<0.05). FMT plus LSI group had reduced total and low-density lipoprotein cholesterol and liver stiffness at week 24 compared with baseline (p<0.05).ConclusionRepeated FMTs enhance the level and duration of microbiota engraftment in obese patients with T2DM. Combining lifestyle intervention with FMT led to more favourable changes in recipients’ microbiota and improvement in lipid profile and liver stiffness.Trial registration numberNCT03127696.
Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects
Authors: Jiménez-Vargas Nestor Nivardo , Yu Yang , Jensen Dane D , Bok Diana Daeun , Wisdom Matthew , Latorre Rocco , Lopez Cintya , Jaramillo-Polanco Josue O , Degro Claudius , Guzman-Rodriguez Mabel , Tsang Quentin , Snow Zachary , Schmidt Brian L , Reed David E , Lomax Alan Edward , Margolis Kara Gross , Stein Christoph , Bunnett Nigel W , Vanner Stephen J 
Published: March 2021

ObjectiveThe effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), which preferentially activates MOPr in acidified diseased tissues, would inhibit pain in a preclinical model of inflammatory bowel disease (IBD) without side effects in healthy tissues.DesignAntinociceptive actions of NFEPP and fentanyl were compared in control mice and mice with dextran sodium sulfate colitis by measuring visceromotor responses to colorectal distension. Patch clamp and extracellular recordings were used to assess nociceptor activation. Defecation, respiration and locomotion were assessed. Colonic migrating motor complexes were assessed by spatiotemporal mapping of isolated tissue. NFEPP-induced MOPr signalling and trafficking were studied in human embryonic kidney 293 cells.ResultsNFEPP inhibited visceromotor responses to colorectal distension in mice with colitis but not in control mice, consistent with acidification of the inflamed colon. Fentanyl inhibited responses in both groups. NFEPP inhibited the excitability of dorsal root ganglion neurons and suppressed mechanical sensitivity of colonic afferent fibres in acidified but not physiological conditions. Whereas fentanyl decreased defecation and caused respiratory depression and hyperactivity in mice with colitis, NFEPP was devoid of these effects. NFEPP did not affect colonic migrating motor complexes at physiological pH. NFEPP preferentially activated MOPr in acidified extracellular conditions to inhibit cAMP formation, recruit β-arrestins and evoke MOPr endocytosis.ConclusionIn a preclinical IBD model, NFEPP preferentially activates MOPr in acidified microenvironments of inflamed tissues to induce antinociception without causing respiratory depression, constipation and hyperactivity.
Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review
Authors: Leng Xinyi , Hurford Robert , Feng Xueyan , Chan Ka Lung , Wolters Frank J , Li Linxin , Soo Yannie OY , Wong Ka Sing Lawrence , Mok Vincent CT , Leung Thomas W , Rothwell Peter M 
Published: March 2021

BackgroundIntracranial arterial stenosis (ICAS) is an important cause of stroke worldwide. Separate reports in Caucasians and Asians with stroke/transient ischaemic attack (TIA) have suggested lower ICAS prevalence in Caucasians, but there has been no direct comparisons of the two ethnic groups with the same criteria to define ICAS.MethodsAcute minor stroke or TIA patients in two cohorts respectively recruiting patients in Oxford (2011–2018, predominantly Caucasians) and Hong Kong (2011–2015, predominantly Chinese) were compared. ICAS was defined as ≥50% stenosis/occlusion in any major intracranial artery in MR/CT angiography. Prevalence, distribution and risk factors of ICAS were compared between the two cohorts. We also systematically reviewed literature on ICAS prevalence in stroke/TIA patients in different populations.ResultsAmong 1287 patients from Oxford and 691 from Hong Kong (mean age 69 vs 66), ICAS prevalence was higher in Chinese than in Caucasians (43.0% vs 20.0%; OR 3.02; 95% CI 2.47 to 3.70; p<0.001), independent of age (age-adjusted OR 3.73; 95% CI 3.00 to 4.63; p<0.001) and vascular risk factors (multivariable-adjusted OR 3.21; 95% CI 2.56 to 4.02; p<0.001). This ethnic difference was greater (p interaction=0.005) at age <70 years (OR 5.33; 95% CI 3.79 to 7.50; p<0.001) than at ≥70 years (OR 2.81; 95% CI 2.11 to 3.74; p<0.001). ICAS prevalence increased with age and with vascular risk factors in both cohorts, with equivalent prevalence in Chinese aged <60 years and Caucasians aged ≥80, and in Chinese with no vascular risk factor and Caucasians with two vascular risk factors. ICAS locations also differed between Chinese and Caucasian patients.ConclusionsChinese are more susceptible to ICAS than Caucasians, with an earlier onset age and a higher prevalence, independent of vascular risk factors.
Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales
Authors: Davies Gwyneth A , Alsallakh Mohammad A , Sivakumaran Shanya , Vasileiou Eleftheria , Lyons Ronan A , Robertson Chris , Sheikh Aziz 
Published: March 2021

Background
The COVID-19 pandemic’s impact on people with asthma is poorly understood. We hypothesised that lockdown restrictions were associated with reductions in severe asthma exacerbations requiring emergency asthma admissions and/or leading to death.

Methods
Using data from Public Health Scotland and the Secure Anonymised Information Linkage Databank in Wales, we compared weekly counts of emergency admissions and deaths due to asthma over the first 18 weeks in 2020 with the national averages over 2015–2019. We modelled the impact of instigating lockdown on these outcomes using interrupted time-series analysis. Using fixed-effect meta-analysis, we derived pooled estimates of the overall changes in trends across the two nations. We also investigated trends in asthma-related primary care prescribing and emergency department (ED) attendances in Wales.

Results
Lockdown was associated with a 36% pooled reduction in emergency admissions for asthma (incidence rate ratio, IRR: 0.64, 95% CI: 0.49 to 0.83, p value 0.001) across both countries. There was no significant change in asthma deaths (pooled IRR: 0.57, 95% CI: 0.17 to 1.94, p value 0.37). ED asthma attendances in Wales declined during lockdown (IRR: 0.85, 95% CI: 0.73 to 0.99, p value 0.03). A large spike of 121% more inhaled corticosteroids and 133% more oral corticosteroid prescriptions was seen in Wales in the week before lockdown.

Conclusions
National lockdowns were associated with substantial reductions in severe asthma exacerbations leading to hospital admission across both Scotland and Wales, with no corresponding increase in asthma deaths.
Retarded resonance Casimir–Polder interaction of a uniformly rotating two-atom system
Authors: Saha Saptarshi , Singha Chiranjeeb , Chatterjee Arpan 
Published: March 2021

AbstractWe consider a two-atom system uniformly moving through a circular ring at an ultra-relativistic speed and weakly interacting with the common quantum fields. Two kinds of fields are introduced here: a massive free scalar field and electromagnetic (EM) vector fields. The vacuum fluctuations of the quantum fields give rise to the resonance Casimir–Polder interaction (RCPI) in the system. Using the quantum master equation formalism, we calculate the second-order energy shift of the entangled states of the system. We find two major aspects of RCPI in a circular trajectory. The first one is the presence of the centripetal acceleration, which gives rise to non-thermality in the system, and secondly, due to the interaction with the above fields, the energy shift for RCPI is retarded in comparison with the massless scalar field. The retardation effect can die out by decreasing the centripetal acceleration and increasing the Zeeman frequency of the atoms. We also show that this phenomenon can be observed via the polarization transfer technique. The coherence time for the polarization transfer is calculated, which is different for the different fields.
Environmental Adaptation of Robot Morphology and Control Through Real-World Evolution
Authors: Nygaard T. F. , Martin C. P. , Howard D. , Torresen J. , Glette K. 
Published: March 2021

Abstract
Robots operating in the real world will experience a range of different environments and tasks. It is essential for the robot to have the ability to adapt to its surroundings to work efficiently in changing conditions. Evolutionary robotics aims to solve this by optimizing both the control and body (morphology) of a robot, allowing adaptation to internal, as well as external factors. Most work in this field has been done in physics simulators, which are relatively simple and not able to replicate the richness of interactions found in the real world. Solutions that rely on the complex interplay among control, body, and environment are therefore rarely found. In this article, we rely solely on real-world evaluations and apply evolutionary search to yield combinations of morphology and control for our mechanically self-reconfiguring quadruped robot. We evolve solutions on two distinct physical surfaces and analyze the results in terms of both control and morphology. We then transition to two previously unseen surfaces to demonstrate the generality of our method. We find that the evolutionary search finds high-performing and diverse morphology-controller configurations by adapting both control and body to the different properties of the physical environments. We additionally find that morphology and control vary with statistical significance between the environments. Moreover, we observe that our method allows for morphology and control parameters to transfer to previously unseen terrains, demonstrating the generality of our approach.
(No) Sympathy for the Devil?
Authors: Steiger Peter 
Published: March 2021

Abstract
As a successor and strong supporter of Origen, though not an uncritical one, Didymus the Blind has long been presented as advocating controversial theological views, notably the apokatastasis. Along with Origen and Evagrius, Didymus’ views on this were condemned by the Fifth Ecumenical Council in 553 CE. In order to better understand Didymus’ theology, it is important to consider his notion of spiritual conflict and its ramifications for the friends and enemies of God. The purpose of this paper is to examine Didymus’ theology of enmity with God, in particular his interpretation of key biblical passages that indicate certain characters as enemies of God, namely Satan, the demons, and Judas Iscariot. The paper will address such questions as should Christians have any sympathy for Satan and the demons? Was Judas’ betrayal merely the selling out of Jesus based on greed, or was there a deeper betrayal of the teacher-student relationship? How do God’s enemies contrast with Didymus’ understanding of the friends of God? In addition to considering Didymus’ exegesis of these characters, the paper will examine his treatment of the New Testament command to love one’s enemies. Didymus’ doctrinal and exegetical texts will both be considered to establish his theology of spiritual conflict. Finally, these considerations will be contextualized within Didymus’ own theological milieu, where the blind scholar seems to be aware of mounting criticism of his theology, perhaps by his own students, and even possibly the conflicts swirling around several of his prominent former students (Evagrius, Jerome and Rufinus).
Surviving in semi-arid environments: functional coordination and trade-offs in shrubs from Argentina
Authors: Delbón Natalia , Castello Lucía V. , Rios-Villamil Alejandro , Cosa María T. , Stiefkens Laura 
Published: March 2021

Abstract
Human action has led to an increase in aridification, making water a progressively scarcer resource. In angiosperms, different species resolve this challenge in diverse ways, mainly through modifications of the xylem network, which is responsible for water efficiency and safety. Xerophytes generally show similar characteristics, but exceptions are rather frequent. One possible explanation for this lack of similarity among cohabiting species is that trade-offs and/or functional coordination between their organs occur and shape alternative survival strategies. Studying species that inhabit a common area can help to identify key traits that determine those diverse strategies and to predict which species might tolerate further environmental change.
We here examined the morpho-anatomical wood and bark traits of a group of species that live in a seasonally dry environment in Argentina. In a previous study, we described the leaf traits of these species and we thus aim to complement our findings and outline their strategies to manage water deficits. Our results show that there are different degrees of xeromorphism within this group. Clear xeromorphic traits, such as high vessel frequency and small diameter, were found in most species. However, some presented traits that were appropriate for mesic environments. An overview of leaf and wood traits indicates that the absence of a typical xeric characteristic in the wood might be compensated by the presence of a xeric leaf trait, and vice versa. Collectively, these trait combinations allow these species to survive in dry conditions and could influence their tolerance to increasing aridity.
The effect of the food environment on fresh produce served in family child care homes
Authors: Fortin-Miller Sara A. , Grantham Catherine E. , Campbell Janis E. , Salvatore Alicia L. , Hoffman Leah A. , Sisson Susan B. 
Published: March 2021

Background: Higher produce consumption in childhood decreases risks of short- and long-term malnutrition, obesity, and disease. Children in early care programs, including family child care homes (FCCHs), receive 50–67% of daily nutrition while in care. Procuring nutritious foods requires grocer access, which is absent in food deserts (FDs). Aim: To determine if FCCH food environment (FE) impacted distance to grocers and amount of fresh produce served. Methods: Using a cross-sectional design, Modified Retail Food Environment Index scores determined census tract FD status. FCCH and grocer addresses were geocoded and distance to the nearest grocers was calculated. Fresh produce was observed during two lunches. Results: FE did not influence distance to grocers or fresh produce served. Non-desert FCCHs tended to serve fresh produce more frequently. The amount of fresh produce served was overall low. Conclusion: Further studies are warranted to inform policies aimed to reduce provider barriers regarding service of fresh produce.
Bedside angiography of distal perfusion catheter for veno-arterial extracorporeal membrane oxygenation
Authors: Shah Aakash , Arons Danielle , Pasrija Chetan , Kon Zachary N , Ghoreishi Mehrdad 
Published: March 2021

Background: The aim of this study was to evaluate the ipsilateral lower extremity (ILE) outcomes of patients who underwent bedside angiography via the distal perfusion catheter while on femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO). Methods: This is a retrospective analysis of all patients placed on VA ECMO at a single center from January 2017 to December 2019 who underwent bedside angiography via the distal perfusion catheter. Results: Twenty-four patients underwent bedside angiography via the distal perfusion catheter after being placed on VA ECMO. A vasodilator was directly administered in three patients for suspected spasm. One patient had distal thrombus and underwent thrombectomy and fasciotomy. One patient had a dislodged catheter and underwent thrombectomy, fasciotomy, and replacement of the catheter. One patient had severe ILE ischemia, however was not intervened upon due to critical acuity. Finally, one patient had inadvertent placement in the saphenous vein and had a new catheter placed in the SFA. No patients underwent amputation. Ultimately, 21 patients (87.5%) had no ILE compromise at the end their ECMO course. Survival to decannulation was 66.7% ( n = 16). Conclusions: Bedside angiography of the distal perfusion catheter is feasible and can be a useful adjunct in informing the need for further intervention to the ILE. Classifications: extracorporeal membrane oxygenation, ischemia
Prediction of MDMA response in healthy humans: a pooled analysis of placebo-controlled studies
Authors: Studerus Erich , Vizeli Patrick , Harder Samuel , Ley Laura , Liechti Matthias E 
Published: March 2021

Background: 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) is used both recreationally and therapeutically. Little is known about the factors influencing inter- and intra-individual differences in the acute response to MDMA. Effects of other psychoactive substances have been shown to be critically influenced by personality traits and mood state before intake. Methods: We pooled data from 10 randomized, double-blind, placebo-controlled, cross-over studies performed in the same laboratory in 194 healthy subjects receiving doses of 75 or 125mg of MDMA. We investigated the influence of drug dose, body weight, sex, age, drug pre-experience, genetics, personality and mental state before drug intake on the acute physiological and psychological response to MDMA. Results: In univariable analyses, the MDMA plasma concentration was the strongest predictor for most outcome variables. When adjusting for dose per body weight, we found that (a) a higher activity of the enzyme CYP2D6 predicted lower MDMA plasma concentration, (b) a higher score in the personality trait “openness to experience” predicted more perceived “closeness”, a stronger decrease in “general inactivation”, and higher scores in the 5D-ASC (5 Dimensions of Altered States of Consciousness Questionnaire) scales “oceanic boundlessness” and “visionary restructuralization”, and (c) subjects with high “neuroticism” or trait anxiety were more likely to have unpleasant and/or anxious reactions. Conclusions: Although MDMA plasma concentration was the strongest predictor, several personality traits and mood state variables additionally explained variance in the response to MDMA. The results confirm that both pharmacological and non-pharmacological variables influence the response to MDMA. These findings may be relevant for the therapeutic use of MDMA.