bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Outcome in Children aged between 6 and 10 years in Major Abdominal Surgery, Neurosurgery and Orthopedic Surgery
Authors: Kumba Claudine 
Published: September 2021

Abstract
BackgroundAnticipating postoperative evolution in surgical patients is an important issue in our daily practice.We demonstrated in a previous study that there were multiple predictors of postoperative outcome, including American Society of Anesthesiologists status (ASA), transfusion, emergency, surgery and age. A detailed description of postoperative outcome was undertaken in children aged between 6 and 10 years old included in the initial study.ObjectiveTo describe postoperative outcomes in children aged between 6 and 10 years old included in the initial cohort in abdominal surgery, neurosurgery and orthopedics.MethodsThe secondary analysis of postoperative outcomes in children aged between 6 and 10 years old was retrospectively included in the initial study of 594 patients. The study was approved by the Ethics Committee.ResultsThere were 88 patients with a mean age of 98.7±13.8 months.The most common surgical interventions were scoliosis in 23 patients (26.1%), limb tumor resection in 8 patients (9.1%), femoral osteotomy in 6 patients (6.8%), intracerebral tumor resection in 6 patients (6.8%), intestinal resection in 5 patients (5.6%), Chiari’s malformation in 4 patients (4.5%), pelvic osteotomy in 4 patients (4.5%) and renal transplantation in 4 patients (4.5%).Most patients (45%) were American Society of Anesthesiologists grade 3 (ASA 3), and 13 (14.8%) were ASA grade 4.Twenty-two (25%) patients had intraoperative and/or postoperative complications (organ dysfunction or sepsis). Two patients (2.3%) had intraoperative hemorrhage, 1 patient (1.1%) had intraoperative difficult intubation, and 1 patient experienced intraoperative anaphylaxis. Nine patients (10.2%) had postoperative neurologic failure, and 2 (2.3%) had postoperative cardio-circulatory failure. Three patients (3.4%) had postoperative septicemia, 2 patients (2.3%) had postoperative pulmonary and urinary sepsis, and 1 patient (1.1%) had postoperative abdominal sepsis. 3 patients (3.4%) had re-operations. 42(47.7%) patients had intra-operative transfusion.There was 1 in-hospital death (1.1%). The median total length of hospital stay was 9 days [5-16].ConclusionTwenty-five percent of the patients had intraoperative and/or postoperative complications, and most of them were ASA grade ³3. Integrating goal-directed therapies to optimize intraoperative management in these patients is necessary to improve postoperative outcomes in surgical pediatric patients.
Relapsing Time to Severe Acute Malnutrition and Hazards Among Children Treated in the Health Posts.
Authors: Lambebo Abera , Temiru Desselegn , Belachew Tefera 
Published: September 2021

Abstract
Background: Malnutrition has many unpleasant results on child health during illness and after discharge. However, in Ethiopia there is luck of study that address either time to relapse or post discharge statusObjective: To identify time of relapse and associated factors among children discharged after undergoing treatment for SAM in South, Ethiopia Methods: An institution Retrospective cohort study was done among children admitted to health posts for treatment of SAM from 2014/2015-2019/2020 under-five children after discharge. After checking all the assumptions finally multivariable Cox regression has been used. All tests were two sided and P values <0.05 were used to declare statistical significance. Results: The mean time for relapse of severe acute malnutrition among under five children was determined us 22 at 95% CI, (20.69-24.82) week from discharge to relapse time.On multivariable negative binomial regression model, after adjusting for background variables time for relapse of severe acute undernutrition was significantly associated with edema during admission (AHR,2.02 ,95%, CI: 1.17-3.50), age group of 6-11 months (AHR 5.2,95%, CI:1.95-13.87), less discharge MUAC for first admission increase hazard of relapse (AHR 12,95%, CI: 7.90-19.52). Conclusion: The mean time was 22 week and edema, Age and MUAC was associated time to relapse.
Semi-Quantitative Chest Computed tomography Score in Novel Coronavirus (SARS-Cov-2) Patients: Its Correlation with Oxygen Saturation (SpO2) and Role in Predicting Oxygen Therapy Requirement.
Authors: Komatlapalli Ramamurthy S. , Arora Abhishek Jagdishchander , Thakur Rajani 
Published: September 2021

Abstract
Context: Quantitative and semi-quantitative indicators of lung involvement in COVID-19 could help to stratify the patients and thus help in triaging and speeding up the entire workflow in hospitals as patients with higher severity scores require early therapeutic intervention and critical care.Objective: To calculate Computed Tomography (CT) severity score for COVID-19 infection based on lobar involvement of the disease and correlate the score with oxygen saturation levels (SpO2) of the patient and further predict oxygen therapy requirement.Settings and Design: Prospective study.Methods and Material: This is a prospective study of 154 proven novel coronavirus (SARS-CoV-2) infected (COVID-19) patients. SpO2 values of all the patients were obtained within 6 hours of scan. All the scans were reviewed and semi-quantitative CT score was calculated based on the extent of lobar involvement Statistical analysis used: Scatter plot correlation and ROC curve analysis were performed. Results: CT score and SpO2 values of patients were plotted in scatter plot chart and Pearson correlation co-efficient (r) was calculated, which was -0.836 suggesting a strong negative correlation. Forty-six patients were given oxygen therapy and they had oxygen saturation value ≤ 94% with CT score ranging from 10-22. ROC curve analysis was performed to determine and reach an optimum cut off value of 11 for oxygen therapy requirement with sensitivity and specificity of 95.83% and 95.58% respectively. Conclusions: CT score in COVID-19 patients has strong negative correlation with oxygen saturation and it definitely helped to predict the requirement of the oxygen therapy in our study.
Phyto-Cleaning of Particulate Matter from Polluted Air by Woody Plant Species in the Near-Desert City of Jodhpur (India) and the Role of Heme Oxygenase in Their Response to PM Stress Conditions
Authors: Popek Robert , Mahawar Lovely , Shekhawat Gyan Singh , Przybysz Arkadiusz 
Published: September 2021

Abstract
Particulate matter (PM) is one of the most dangerous pollutants in the air. Urban vegetation, especially trees and shrubs, accumulate PM and reduce its concentration in ambient air. The aim of this study was to examine 10 tree and shrub species common for the Indian city of Jodhpur (Rajasthan) located on the edge of the Thar Desert and determine: (1) the accumulation of surface and in-wax PM (both in three different size fractions), (2) the amount of epicuticular waxes on foliage, (3) the concentrations of heavy metals (Cd and Cu) on/in the leaves of the examined species, and (4) the level of heme oxygenase enzyme in leaves that accumulate PM and heavy metals. Among the investigated species, F. religiosa and C. myxa accumulated the greatest amount of total PM. F. religiosa is a tall tree with a lush, large crown and leaves with wavy edge, convex veins and long petioles, while C. myxa have hairy leaves with convex veins. The lowest PM accumulation was recorded for drought resistant S. persica and A. indica, which is probably due to their adaptation to growing conditions. Heavy metals (Cu and Cd) were found in the leaves of almost every examined species. The accumulation of heavy metals (especially Cu) was positively correlated with the amount of PM deposited on the foliage. A new finding of this study indicated a potentially important role of HO in the plants’ response to PM-induced stress. The correlation between HO and PM was stronger than that between HO and HMs. The results obtained in this study emphasise the role of plants in cleaning polluted air in conditions where there are very high concentrations of PM.
Sexual Quality of Life Assessment in Young Women with Breast Cancer During Adjuvant Endocrine Therapy and Patient-Reported Supportive Measures
Authors: Bobrie Angelique , Jarlier Marta , Moussion Aurore , Jacot William , D'Hondt Veronique 
Published: September 2021

Abstract
Purpose: sexual quality of life (QoL) is affected during and after breast cancer (BC) treatment. The purpose was to investigate sexual and global QoL and patient-reported measures to address this issue in young women (< 51 years) with BC after the acute treatment phase, during adjuvant endocrine therapy. Methods: three EORTC questionnaires and an additional specific questionnaire, developed for the study, were used to assess sexual and global QoL and patient-reported supportive measures in BC patients who had received their endocrine therapy for at least 24 months.Results: We showed a deterioration of the sexual QoL and a poor communication with healthcare professionals. Most patients (88.9%) declared important that sexuality should be discussed with caregivers and that the partner should also be involved. Most patients (60%) had taken at least one action to overcome their sexual problems. Most of these interventions (63%) originated from the patient herself. Conclusions: sexual QoL is a major issue in young BC patients and is poorly addressed by healthcare professionals. Most of the supportive methods used by the patients to overcome these side effects were at their own initiative. Communication and counseling on sexuality from healthcare professionals needs to be improved during BC treatment. Patients suggested supportive measures they would find useful and appropriate to develop in clinic. The final goal being to improve sexual QoL of BC patients with the appropriate intervention and support.NCT 04200001
Optimization of Coagulation-flocculation Process for Pre-treatment of Artisanal Tannery Wastewater Using Response Surface Methodology
Authors: Appiah-Brempong Miriam , Essandoh Helen Michelle Korkor , Asiedu Nana Yaw , Dadzie Samuel Kwame , Momade Francis Yao 
Published: September 2021

Abstract
There is a dearth in knowledge on artisanal tannery wastewater treatment as most studies are focused on treatment of wastewater generated from modern-day leather manufacturing industries. The extensive use of plant materials in artisanal tanneries introduces high loads of polyphenolic compounds in the wastewater rendering biological treatment of the wastewater ineffective. This study, therefore, employed coagulation-flocculation process to pre-treat artisanal tannery wastewater with the aim of applying the central composite design, a statistical approach in Response Surface Methodology (RSM) to model and optimize the removal of Chemical Oxygen Demand (COD), Total Suspended Solids (TSS) and turbidity and to minimize Sludge Volume Index (SVI). Optimization process focused on the two most important influencing parameters: dosage of aluminium sulphate and initial pH of wastewater. Results revealed that optimal pH and aluminium sulphate dosage of 6.09 and 11.6g/L respectively could yield maximum removal efficiencies of 38.51% of COD, 76.05% of TSS and 79.64% of turbidity from the wastewater with a minimum SVI of 29.57mL/g. Further experiments conducted to validate these results showed a good agreement between the experimental and predicted results signifying the suitability of RSM for optimization of the coagulation treatment process. This is the first reported study on optimization of coagulation-flocculation treatment of artisanal tannery wastewater. Results of this study can be used practically for efficient pre-treatment of artisanal tannery wastewater.
Early Ambulation Training as Impairment-Driven Rehabilitation in Cancer Patients with Cervical Spine Metastases After Palliative Spine Surgery
Authors: Ishida Yukako , Shigematsu Hideki , Tsukamoto Shinji , Morimoto Yasuhiko , Iwata Eiichiro , Okuda Akinori , Kishi Shingo , Fujii Hiromasa , Honoki Kanya , Tanaka Yasuhito , Kido Akira 
Published: September 2021

Abstract
Background

Cervical spine metastasis worsens the quality of life (QOL) of patients with cancer. While the beneficial effects of surgery have been reported, the detailed course of functional recovery remains unclear, especially in the acute phase of rehabilitation. We previously reported on impairment-driven rehabilitation in patients with thoracic or lumbar level metastases. The present study assessed the effects of an impairment-driven strategy on the early recovery of ambulatory function in patients with cervical spine metastasis.
Methods

We retrospectively reviewed 13 consecutive patients with cervical neoplastic spinal compression. The patients were those whose primary impairment with spinal instability identified by a multidisciplinary tumor board who underwent palliative spine surgery. In addition, we examined neurological deficits; ambulation status; pathological fracture, collapse, and postoperative implant failure progress; and Barthel Index (BI).
Results

The average duration of ambulation was 3.75 ± 3.92 days after surgery. One case showed collapse and two showed progressions of paralysis. However, all patients had early ambulation after surgery, except for one patient who developed postoperative cerebral infarction. The BI scores showed an improving tendency; however, the difference before and after rehabilitation was not statistically significant.
Conclusions

We reviewed the recovery course of ambulation in patients with cervical spine metastases who underwent impairment-driven rehabilitation. Combined with surgery and early mobilization, this strategy may improve the QOL of patients with cancer and cervical spine metastasis.
Correlation Between Physical Activity Level and Functional Status of Subjects with High Spinal Cord Injury
Authors: Szeliga Ewa , Borys Renata , Brzozowska-Magoń Agnieszka , Wolan-Nieroda Andżelina , Magoń Grzegorz , Walicka-Cupryś Katarzyna 
Published: September 2021

Abstract
Background. Spinal cord injuries are one of the main causes of disability in Poland and in the world. Quadriparesis, limitations in activities of daily living, lack of full autonomy and psycho-social problems are consequences of cervical spinal cord injury. Due to the consequences, especially motor paralysis and sedentary lifestyle resulting from spinal injuries, much attention is drawn to physical activity in subjects with this type of injuries. Objective. The aim of the study is to assess the effect of regular physical activity on functional fitness and independent existence of subjects after high spinal cord injury.Methods. 80 subjects with transverse injury of cervical spinal cord were enrolled in the study. The study group included men aged 20-50, in which group 40 (50%) of the subjects were qualified to the physically active group – subjects doing wheelchair sport, and 40 (50%) of the subjects were qualified to the physically inactive group – subjects taking no physical activity. The physically active men were qualified on the basis of their participation in organised activities - wheelchair rugby. Minimum participation was 90 minutes a day twice a week. Subjects from the physically inactive group had a passive lifestyle and participated in no sports activities. Results. Highly significant differences were observed during the study between the physically active and inactive men with regard to the functionality status. The study subjects taking regular physical exercise had better results in all assessed activities. The biggest differences were observed in the field of toilet and dressing up. Conclusions. The study confirmed that regular physical activity is correlated with better fitness. The study also showed that the subjects playing wheelchair rugby are more independent, which results in their better functional status in everyday life.
LncRNA MIR4435-2HG Promotes Proliferation, Migration, Invasion and EMT Via Targeting miR-22- 3p/TMEM9B in Breast Cancer
Authors: Ke Jing , Wang Quhui , Zhang Wei , Mei Haijun 
Published: September 2021

Abstract
Background: Breast cancer, as the malignancy with the highest incidence rate and mortality rate in women, seriously threatens human life and health. Pieces of evidence have suggested that long non-coding RNAs (lncRNAs) possess important effects on regulating the occurrence and development of breast cancer.Results: In the present study, MIR4435-2HG was highly expressed in breast cancer tissues and cells. Down-regulation of MIR4435-2HG inhibited the viability, proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of breast cancer cell lines by Cell Counting Kit-8 (CCK-8), colony formation, transwell migration and invasion, immunofluorescence and western blot assays. Dual-luciferase reporter assay and RNA pull-down analysis confirmed that miR-22-3p was a target of MIR4435-2HG. Over-expression of MicroRNA-22-3p (miR-22-3p) obviously inhibited the viability, proliferation, migration, invasion and EMT of breast cancer cell lines. Transmembrane protein 9 domain family member B (TMEM9B) was up-regulated in breast cancer tissues and cell lines. Dual-luciferase reporter assay confirmed that TMEM9B was a target of miR-22-3p. TMEM9B inhibition partially restored the effects of MIR4435-2HG/miR-22-3p on the viability, proliferation, migration, invasion and EMT of breast cancer cell lines.Conclusions: MIR4435-2HG potentially played a tumor-promoting role in the occurrence and development of breast cancer, which might be achieved by regulating the miR-22-3p/TMEM9B axis.
Glibenclamide Reduces Excitatory Postsynaptic Currents In CA1 Hippocampal Neurons In A Mouse Model of Multiple Sclerosis
Authors: Fearey Brenna C. , Binkle Lars , Mensching Daniel , Schulze Christian , Lohr Christian , Friese Manuel A. , Oertner Thomas G. , Gee Christine E. 
Published: September 2021

Abstract
The transient receptor potential melastatin 4 (TRPM4) channel contributes to disease severity in the murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and to neuronal cell death in models of excitotoxicity and traumatic brain injury. As TRPM4 is activated by intracellular calcium and conducts monovalent cations, we hypothesized that TRPM4 may contribute to and boost excitatory synaptic transmission in CA1 pyramidal neurons of the hippocampus. Using single-spine calcium imaging and electrophysiology, we found no effect of the TRPM4 antagonists 9-phenanthrol and glibenclamide on synaptic transmission in hippocampal slices from healthy mice. In contrast, glibenclamide but not 9-phenanthrol reduced excitatory synaptic potentials in slices from EAE mice, an effect that was absent in slices from EAE mice lacking TRPM4. We conclude that TRPM4 plays little role in basal hippocampal synaptic transmission but a glibenclamide-sensitive TRPM4-mediated contribution to excitatory postsynaptic responses is upregulated at the acute phase of EAE.
Patient Satisfaction, Needs and Preferences Concerning Information Dispensation at the Emergency Department; A Cross-Sectional Observational Study
Authors: de Steenwinkel Marank , Haagsma Juanita A , Berkel Esther C.M. van , Rozema Lotte , Rood Pleunie P.M. , Bouwhuis Marna G 
Published: September 2021

Abstract
Background Patient satisfaction is an important indicator of emergency care quality and has been associated with information dispensation at the Emergency Department (ED). Optimal information dispensation could improve patient experience and expectations. Knowing what kind of information patients want to receive and the preferred way of information dispensation are essential to optimize information delivery at the ED. The purpose of this cross-sectional observational study was to evaluate patient satisfaction concerning information dispensation (including general, medical and practical information), the need for additional information and preferences with regards to the way of information dispensation at the ED of a teaching hospital in the Netherlands. Results423 patients (patients ≥18 years with Glasgow Coma Scale 15) were enrolled (response rate 79%). The median patient satisfaction score concerning the overall information dispensation at the ED was 7.5 on a rating scale 0-10. Shorter length of ED stay was associated with higher patient satisfaction in multivariate analysis (P<0.001). The majority of respondents was satisfied regarding medical (N=328; 78%) and general information (N =233; 55%). Patients were less satisfied regarding practical information (N =180; 43%). Respondents who indicated that they received general, medical and practical information were significantly more often satisfied compared to patients who did not receive this information (P<0.001). Two thirds (N=260; 62%) requested more general information. Half of the respondents (N=202; 48%) requested more practical information and a third (N=152; 36%) requested more medical information. The preferred way for receiving information was orally (N=189; 44.7%) or by leaflets (N=108; 25.5%).ConclusionThe majority of respondents were satisfied concerning information dispensation at the ED, especially regarding medical information. Respondents requested more general and practical information and preferred to receive the information orally or by leaflets.
Population Attributable Fractions of Caffeine and Water Pipe on low birth weight: The Bandar-Abbas Population-based Cohort in suburban areas
Authors: Nematollahi Shahrzad , Mansournia Mohammad Ali , Rahimi-Foroushani Abbas , Mouseli Ali , Shabkhiz Hossein , Holakouie-Naieni Koroush 
Published: September 2021

Abstract
Background: Low Birth Weight (LBW) poses a major health challenge in low-resource suburban communities. Despite relatively commonality, there is little evidence on the effects of water pipe and dietary caffeine on reproductive outcomes in the Middle-East region. The Bandar Abbas Pregnancy Cohort (BAPC), as a population-based prospective study, has been investigating the effects of lifestyle and environmental factors on maternal wellbeing and child growth and development in suburban communities in the south of Iran. This study used the BAPC data to estimate the attribution of LBW incidence to fully or partially removal of dietary caffeine intake and water pipe smoking during pregnancy.Methods: ‎The present study used data on 861 live singleton pregnancies in the first two BAPC visits (response rate= 95.42%). Water pipe smoking (yes/no) was measured during pregnancy using a structured checklist recommended by the World Health Organization (WHO). Dietary caffeine intake was measured during pregnancy using a structured checklist and categorized into low for 0-99 mg/day, and high for>100 mg/day. LBW (yes/no) was determined using recorded birth weight in infant`s vaccination card. Exposure relative risks were calculated using Modified Poisson regression models. Population Attributable Fractions (PAFs) and Generalized Impact Fractions (GIFs) were calculated on relative risk scale. The prevalence of counter fact was set as 3% for water pipe smokers and 14.9% for intake of >100 mg/day caffeine.Results: The cumulative incidence of LBW was 16.1%. An estimated 19% (95%CI: 6, 30%) and 11% (95%CI: 8, 14%) of LBW were attributed to high intake of dietary caffeine and water pipe smoking, respectively. Reducing the intake of caffeine to less than 100 mg/day or prevalence of water pipe to 3% would prevent 10.7% (95%CI: 6.6, 25.3%) and 5.7% ‎‎(95%CI: ‎5.0, 6.8%) of LBW incidence, respectively. ‎Conclusions: Our findings have provided evidence on quantitative contributions of caffeine and water pipe on LBW using real-world data. Integration of this information into practical action plans to prevent LBW is the next step in our cohort project. Furthermore, to get an overarching picture and in-depth understanding of reproductive effects of caffeine and water pipe, exercising this study`s analytic approach in other contexts is encouraged. ‎