bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of peri‐implant diseases around subcrestally placed implants: A cross‐sectional study
Authors: Obreja Karina , Ramanauskaite Ausra , Begic Amira , Galarraga‐Vinueza Maria Elisa , Parvini Puria , Sader Robert , Schwarz Frank 
Published: March 2021

AbstractObjectivesTo evaluate the prevalence of peri‐implant health, peri‐implant mucositis or periimplantitis for subcrestally placed implants (1–3 mm) on the short‐, medium‐ and long term.Material and MethodsTwo hundred patients were enrolled in this cross‐sectional study that were treated and screened during regular maintenance visits at one university center. A total of 657 implants were evaluated. Peri‐implant health and diseases were assessed according to predefined case definitions. Binary logistic regression was used to assess the correlation with local and systemic factors.ResultsAfter a median function time of 9.36 ± 6.44 years (range: 1–26 years), the prevalence of peri‐implant mucositis and peri‐implantitis was 66.5% and 15.0%, at the patient level, corresponding to 62.6% and 7.5%, at the implant level, respectively. Peri‐implantitis was significantly associated with patients’ history of periodontitis (odds ratio, OR 5.33).ConclusionPeri‐implant diseases were a common finding around subcrestally placed implants.
Clinical efficacy of simvastatin gel combined with polypropylene membrane on the healing of extraction sockets: A triple‐blind, randomized clinical trial
Authors: Cruz Rebecca , Moraschini Vittorio , Calasans‐Maia Monica Diuana , de Almeida Daniel Costa Ferreira , Sartoretto Suelen Cristina , Granjeiro José Mauro 
Published: March 2021

AbstractObjectivesThis study aimed to evaluate dimensional changes, level of soft tissue healing, and pain/discomfort perception in post‐extraction sockets filling with 1.2% simvastatin (SIM) gel covered with polypropylene membranes (PPPM).Material and methodsTwenty‐six post‐extraction sockets of posterior teeth were randomly allocated in two groups: (a) socket filling with 1.2% SIM gel and covered with PPPM (n = 13) and (b) socket filling with placebo gel and covered with PPPM (n = 13). Cone‐beam computed tomography (CBCT) images before and 90 days after the extraction enabled alveolar bone dimensional changes calculation using horizontal and vertical measurements. The measurements occurred at three different levels for thickness located 1, 3, and 5 mm from the top of the bone crest. The vertical (depth) measure was assessed from the most apical portion of the socket to the bone crest's most coronal portion. Seven days after the extractions, the level of soft tissue healing and pain perception were also analyzed.ResultsAfter 90 days of extractions, the dimensional changes in thickness in the test group were significantly smaller in sections A (p = .044), B (p = .036) and C (p = .048) when compared to the control group. The test group showed a significantly lower height‐dimensional change than the control group (p < .0001). Soft tissue healing index (p = .63), perception of pain (p = .23), and number of analgesics consumed (p = .25) were similar between groups.ConclusionsSimvastatin at 1.2% compared with placebo effectively reduced the dimensional changes in post‐extraction sockets covered with PPPM. There was no significant difference in the level of soft tissue healing and postoperative pain between the test and control groups.
Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation—A randomized controlled clinical trial
Authors: Mercado Faustino , Vaquette Cedryck , Hamlet Stephen , Ivanovski Sašo 
Published: March 2021

AbstractObjectivesTo compare the effectiveness of deproteinized bovine bone mineral with 10% collagen alone (DBBMC) or with enamel matrix derivative (DBBMC‐EMD) in ridge preservation.Methods42 maxillary anterior teeth were extracted and received either a DBBMC (control) or DBBMC‐EMD (test) treatment protocol. CBCT taken before and 4 months after the extraction procedure was used to measure changes in alveolar ridge width (RW), buccal bone height (BH) and palatal bone height (PH). Bone cores were harvested during implant osteotomy preparation, and the samples processed histomorphometrically to assess the fraction of new bone (%NB), residual graft (%RG) and soft tissue matrix (%STM).ResultsOverall, both treatment groups showed significant reductions in mean RW from baseline to 4 months after extraction, but no significant change in either mean BH or PH over this time. When CBCT measurements were analysed according to the initial thickness of the buccal wall (BT < 1 mm vs. BT ≥ 1 mm), significant reductions in all ridge dimensions (RW, BH and PH) were noted in the <1 mm BT group. Histomorphometrically, the DBBMC‐EMD test group showed significantly increased new bone formation (%NB): (control = 16.5 ± 6.9% cf.; test = 45.1 ± 8.8%) with less residual graft (%RG): (control = 36.8 ± 8.8% cf.; test = 20.3 ± 7.2%) compared to the DBBMC control group.ConclusionsBoth DBBMC alone and DBBMC‐EMD treated sites 4 months after extraction lost RW but showed no significant change in BH or PH. Irrespective of treatment, maxillary anterior teeth with thick initial buccal walls (≥1 mm) exhibited less alveolar ridge reduction 4 months after treatment. The addition of EMD to DBBMC resulted in more new bone formation in the test group.
Chronic cough is associated with depressive mood in women regardless of smoking status and lung function
Authors: Heo I Re , Kim Ju‐Young , Go Se‐Il , Kim Tae Hoon , Ju Sunmi , Yoo Jung‐Wan , Lee Seung Jun , Cho Yu Ji , Jeong Yi Yeong , Lee Jong Deog , Kim Ho Cheol 
Published: March 2021

AbstractBackgroundChronic cough is a common respiratory symptom, and, if persistent, the patient’s quality of life can worsen and result in a depressive mood, or vice versa. Although previous reports suggest a relationship between chronic cough and depression, we further investigated this relationship according to smoking status and lung function.MethodsThis observational study used cross‐sectional data from the 6th Korean National Health and Nutrition Examination Survey (2014 and 2016). Propensity score matching using age, sex, smoking status, and lung function was performed for participants with and without chronic cough to reduce the confounding effects associated with depressive mood. Questionnaires recorded coughs persisting for >3 months and the Patient Health Questionnaire‐9 (PHQ‐9) assessed the severity of depressive mood.ResultsAmong 12 494 participants who were >18 years old, 226 with chronic cough were matched with 226 with non‐chronic cough. Overall, chronic cough participants showed higher PHQ‐9 scores than the non‐chronic cough participants (4.29 ± 5.23 vs. 2.63 ± 3.38, P < .001). When stratified by sex, the difference remained significant in women (5.69 ± 5.96 vs. 3.05 ± 3.97, P < .001) but not in men (3.18 ± 4.27 vs. 2.31 ± 3.65, P = .092). When stratified by lung function status, the difference remained significant for those with normal lung function (4.32 ± 5.32 vs. 2.78 ± 3.86, P = .003) and reduced lung function (4.19 ± 4.93 vs. 2.11 ± 3.55, P ≤ 0.001). Multivariate logistic regression analysis revealed that chronic cough was associated with PHQ‐9 score (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.014–1.27, P = .014), chronic obstructive pulmonary disease (OR, 4.87; 95% CI, 1.041–22.86, P = .044) and physician‐diagnosed bronchial asthma (OR, 2.93; 95% CI, 1.162–7.435, P = .023).ConclusionsDepressive mood is significantly correlated with chronic cough in females.
A comparison of cardiopulmonary bypass versus extracorporeal membrane oxygenation: Does intraoperative circulatory support strategy affect outcomes in pediatric lung transplantation?
Authors: Parikh Amisha N. , Merritt Taylor C. , Carvajal Horacio G. , Shepard Mark S. , Canter Matthew W. , Abarbanell Aaron M. , Eghtesady Pirooz , Nath Dilip S. 
Published: March 2021

AbstractObjectiveData on adult lung transplantation suggest perioperative benefits of intraoperative extracorporeal membrane oxygenation (ECMO) compared to cardiopulmonary bypass (CPB). Information regarding their pediatric counterparts, however, is limited. This study compares outcomes of intraoperative ECMO versus CPB in pediatric lung transplantation.MethodsWe reviewed all pediatric lung transplants at our institution from 2014 to 2019 and compared those supported intraoperatively on ECMO (n = 13) versus CPB (n = 22), plus a conditional analysis excluding re‐transplantations (ECMO [n = 13] versus CPB [n = 20]). We evaluated survival, surgical times, intraoperative transfusions, postoperative support, complications, and duration of hospitalization.ResultsTotal time on ECMO support was significantly less than that of CPB support (P = .018). Intraoperatively, the ECMO group required fewer transfusions of fresh‐frozen plasma (8.9 [5.8‐22.3] vs 16.6 [11.4‐39.0] mL/kg, P = .049) and platelets (4.2 [0.0‐6.7] vs 8.0 [3.5‐14.0] mL/kg, P = .049). When excluding re‐transplantations, patients on ECMO required fewer packed red blood cells intraoperatively (12.6 [2.1‐30.7] vs 28.2 [14.0‐54.0] mL/kg, P = .048). There were no differences in postoperative support requirements, complications, or mortality at one, six, and twelve months.ConclusionsIntraoperative ECMO support during pediatric lung transplantation appears to decrease intraoperative transfusion requirements when compared to CPB. Data from additional institutions may strengthen these observations.
Trends in adolescent alcohol and other risky health‐ and school‐related behaviours and outcomes in Australia
Authors: Vashishtha Rakhi , Pennay Amy , Dietze Paul M. , Livingston Michael 
Published: March 2021

AbstractIntroductionAdolescent drinking has been declining in Australia over the past two decades, but this trend may be part of a broader shift towards healthier lifestyles for adolescents. We examined trends in the prevalence of multiple risky health‐ and school‐related behaviours and outcomes to test whether this was the case.MethodsData on multiple behaviours and outcomes were collated from Australian government agencies and other relevant sources for 10–19‐year‐olds from the year 2000 onward. Trends were examined descriptively.ResultsRates of substance use, youth offending and injuries due to underage driving declined over the study period. Some health‐related behaviours (physical activity and diet) worsened between 2001 and 2017; however, obesity rates remained stable. Risky sexual behaviours increased in terms of early initiation of lifetime sexual intercourse and decreased condom use. However, sexual health outcomes improved with a reduction in teenage pregnancies and there was a recent decline in sexually transmitted infection rates from 2011 onward. Suicide rates and rates of major depressive disorders increased. School attendance and engagement in full‐time work or study remained stable.Discussion and ConclusionsThe decline in adolescent drinking does not appear to correspond with increased engagement in healthier behaviours; however, it may be related to a more risk‐averse way of living. Future work could be directed towards identifying which social, economic, policy and environmental factors have impacted positive changes in risky behaviours. Public health efforts can then be directed towards behaviours or outcomes, which have not yet improved.
Attitudinal factors associated with drink counting
Authors: Booth Leon , Jongenelis Michelle I. , Drane Catherine , Miller Peter G. , Chikritzhs Tanya , Hasking Penelope , Hastings Gerard , Thorn Michael , Pettigrew Simone 
Published: March 2021

AbstractIntroduction‘Count your drinks’ is a protective behavioural strategy (PBS) that has been found to be effective in reducing alcohol consumption. Previous research has shown that females, older people and low‐risk drinkers are more likely to use this strategy, but little is known about the attitudinal factors associated with engaging in drink counting. This information is important for developing effective interventions to encourage use of this PBS. The aim of this paper was to assess whether the following attitudinal factors are associated with frequency of enactment of the ‘Count your drinks’ PBS: (i) perceived ease of use; (ii) perceived effectiveness; (iii) personal relevance; and (iv) believability.MethodsA total of 683 Australian drinkers completed an online survey assessing demographic variables, alcohol consumption, frequency of drink counting and attitudes to the ‘Count your drinks’ PBS. A hierarchical regression analysis was used to determine whether the attitudinal factors were associated with frequency of enactment after controlling for demographic and alcohol‐related factors.ResultsAttitudes to the ‘Count your drinks’ PBS accounted for 28% of the variance in reported frequency of drink counting. Perceptions of personal relevance, ease of use and effectiveness were found to be significantly associated with frequency of enactment.Discussion and ConclusionsInterventions designed to encourage drinkers to count their drinks should aim to increase the perceived personal relevance, ease of use and effectiveness of this strategy.
Sperm performance limits the reproduction of an invasive fish in novel salinities
Authors: Green Leon , Niemax Jan , Herrmann Jens‐Peter , Temming Axel , Behrens Jane W. , Havenhand Jonathan N. , Leder Erica , Kvarnemo Charlotta 
Published: March 2021

AbstractAimThe few fish species able to reproduce across wide osmotic ranges either plastically acclimate sperm performance to, or are locally adapted to, different salinities. The invasive round goby (Neogobius melanostomus) is spreading in Eurasia and the Americas, into both fresh and brackish water. We aim to understand if reproduction in different salinities is affected by an ability to acclimate.LocationBrackish and freshwater systems of northern Europe and the Baltic Sea.MethodsWe cross‐exposed round gobies of freshwater and brackish origin to 0 and 16 practical salinity units (PSU), and the fish were given nest boxes in which to spawn. After 4 weeks, we measured their sperm performance in both 0 and 16 PSU; fertilization success of each egg clutch was measured through visual analysis of eggs. Clutches were split and allowed to develop in both 0 and 16 PSU salinity, and reproductive success (zygote development) was measured 20 ± 1 days later. Responses were analysed using generalized mixed models.ResultsAfter a month, the fish showed no plasticity in sperm performance to their acclimation salinity, regardless of their origin. Sperm velocity was highest in the salinity similar to the males’ origin. Significantly lower fertilization success was measured for individuals that reproduced outside their salinity of origin despite recurring spawning events in all treatment groups. Among fertilized eggs, zygote development was similar regardless of salinity treatment of either eggs or parents.Main ConclusionsShort‐term acclimation to new salinities does not affect sperm performance in the round goby. Alternative hypotheses such as local adaption should be further investigated. Limits to the species’ reproductive success, and therefore invasion processes, are likely dependent on environment‐phenotype matches. Fish of brackish origin spawned successfully in freshwater, pointing to an increased risk of introducing populations of brackish origin into freshwater.
Developing context‐relevant project experiences for marketing analytics students
Authors: Lim Jeen‐Su , Heinrichs John H. 
Published: March 2021

ABSTRACTToday's firms are inundated with a huge volume of data and face requirements to use this data to gain and maintain competitive advantage. In this teaching brief, we address the confirmed analytic skills gap by providing context‐relevant learning experiences to business students. Specifically, a marketing analytics project development model is proposed, with details on its design and implementation in a senior‐level course at a major Midwestern university. The course content and project were administered through a learning management system using HubSpot's CRM software tools. For the project, students were provided with data visualizations for a hypothetical firm; then they performed additional analysis using HubSpot CRM dashboards. Final student projects, as well as course evaluations, suggest that students gained enhanced marketing analytics skills that will be valuable in the future job market.
Developing a distinctive consulting capstone course in a supply chain curriculum
Authors: Roethlein Christopher J. , McCarthy Byrne Teresa M. , Visich John K. , Li Suhong , Gravier Michael J. 
Published: March 2021

ABSTRACTThis article describes a required capstone course for students in the Global Supply Chain Management (GSCM) Program at Bryant University, designed to prepare students for a career in supply chain management. Student teams work on semester‐long projects for locally and regionally based companies. The projects are supported by all GSCM faculty who teach in the Information Systems and Analytics, Management, and Marketing departments. Since the inception of this capstone course in the fall of 2010, a total of 83 projects for 42 companies have been completed. Hence this article discusses an extensive number of projects over an extended period of time, and our insights should be of interest to supply chain faculty who currently have, or plan to include, empirical projects as a key component of their course or supply chain program. We present a brief literature review on teaching supply chain management, and then describe the practicum capstone course, Empirical Applications in Global Supply Chain Management. We provide company and project descriptions and discuss project outcomes. Students have estimated savings/earnings impact of $109.5 million from 35 projects completed over a 4‐year period. Although not without challenges, the practicum capstone course provides students with an integrative, multidisciplinary experience that better prepares them for their careers.
Diastolic function as an early marker for systolic dysfunction and all‐cause mortality among cancer patients
Authors: Arnold Joshua H. , Rozenbaum Zach , Hochstadt Aviram , Rosen Roni , Sherez Chen , Sivan Ayelet , Mor Liat , Moshkovits Yonatan , Sadeh Ben , Havakuk Ofer , Milwidsky Assi , Shamai Sivan , Sirota Dorfman Svetlana , Arbel Yaron , Topilsky Yan , Laufer‐Perl Michal 
Published: March 2021

AbstractBackgroundIncreased survival among active cancer patients exposes a wide range of side effects, including cardiotoxicity, manifested by systolic dysfunction and associated with morbidity and mortality. Early diagnosis of subclinical function changes and cardiac damage is essential in the management of these patients. Diastolic dysfunction is considered common among cancer patients; however, its effect on systolic dysfunction or mortality is still unknown.MethodsData were collected as part of the Israel Cardio‐Oncology Registry, enrolling and prospectively following all patients evaluated in the cardio‐oncology clinic in the Tel Aviv Sourasky Medical Center. All patients underwent echocardiographic examinations including evaluation of diastolic parameters and global longitudinal strain (GLS). Systolic dysfunction was defined as either an absolute reduction >10% in left ventricular ejection fraction to a value below 53% or GLS relative reduction >10% between the 1st and 3rd echocardiography examinations.ResultsOverall, 190 active cancer patients were included, with a mean age of 58 ± 15 years and a female predominance (78%). During a median follow‐up of 243 days (interquartile ranges [IQR]: 164‐401 days), 62 (33%) patients developed systolic dysfunction. Over a median follow‐up of 789 days (IQR: 521‐968 days), 29 (15%) patients died. There were no significant differences in baseline cardiac risk factors between the groups. Using multivariate analysis, E/e′ lateral and e′ lateral emerged as significantly associated with systolic dysfunction development and all‐cause mortality (P = .015).ConclusionAmong active cancer patients, evaluation of diastolic function may provide an early marker for the development of systolic dysfunction, as well as all‐cause mortality.
Augmented human development in the age of globalization†
Authors: Prados de la Escosura Leandro 
Published: March 2021

AbstractA long‐run view of well‐being over the last one‐and‐a‐half centuries is presented using an Augmented Human Development Index (AHDI) that combines achievements in health, education, material living standards, and political freedom. The AHDI shows substantial gains in world human development since 1870, although significant room for improvement still remains. The AHDI spread unevenly until 1960, in absolute terms, and up to 1929 in relative ones, and reversed this trend thereafter. The main relative gain went to world countries’ middle class, but the main absolute gain accrued to the top decile. AHD trends and distribution do not match, but compare favourably with, those in per capita income. The absolute gap between present‐day advanced countries and the rest of the world deepened over time, though fell in relative terms. Life expectancy has led progress in AHD, particularly until 1970, and drove the catching‐up by the rest of the world during the epidemiological transition. Political and civil liberties took over thereafter.
A new reliable and highly specific monoclonal antibody to detect the C‐terminal region of silencer of cytokine signaling 1
Authors: Weissinger Stephanie E. , Zahn Malena , Marienfeld Ralf , Tessmer Claudia , Moldenhauer Gerhard , Möller Peter 
Published: March 2021

AbstractIntroductionSOCS1, a negative regulator of JAK/STAT signaling, is among the most frequently mutated genes in DLBCL and classical Hodgkin lymphoma. The C‐terminal SOCS box domain, mediating the degradation of phospho‐JAK2, is often affected or even lacking. The analysis of such variants is hampered by the lack of a SOCS1‐specific monoclonal antibody recognizing the C‐terminus of SOCS1. As this C‐terminus is often lost or mutated in B‐cell lymphomas, staining with amino‐terminal targeting antibodies in a lymphoma setting might be misleading.MethodsBALB/c mice were immunized with a truncated SOCS1 C‐terminal protein. The supernatant of generated hybridoma cells was screened by ELISA and, immunohistochemically, on formalin‐fixed and paraffin‐embedded tonsil. After antibody purification by affinity chromatography, epitope mapping and cross‐reactivity check followed via substitution scans. SOCS1 protein expression was investigated on cell cultures and cytoblocks of SOCS1WT stably transfected HEK293T cells, lymphoma cell lines and lymphoid tissues.ResultsProcedures resulted in one monoclonal IgG1 anti‐SOCS1 antibody, 424C, that recognizes and strongly binds to the C‐terminal region of SOCS1 in immunoblot and immunohistochemistry analyses.ConclusionThis new anti‐SOCS1 monoclonal antibody is a valuable tool to detect SOCS1 expression dependent on an existing SOCS1 box and, therefore, indicating a full‐length SOCS1 protein.