bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Related Differences in the Online Processing of Spoken Semantic Context and the Effect of Semantic Competition: Evidence From Eye Gaze
Authors: Harel-Arbeli Tami , Wingfield Arthur , Palgi Yuval , Ben-David Boaz M. 
Published: February 2021

Purpose
The study examined age-related differences in the use of semantic context and in the effect of semantic competition in spoken sentence processing. We used offline (response latency) and online (eye gaze) measures, using the “visual world” eye-tracking paradigm.

Method
Thirty younger and 30 older adults heard sentences related to one of four images presented on a computer monitor. They were asked to touch the image corresponding to the final word of the sentence (target word). Three conditions were used: a nonpredictive sentence, a predictive sentence suggesting one of the four images on the screen (semantic context), and a predictive sentence suggesting two possible images (semantic competition).

Results
Online eye gaze data showed no age-related differences with nonpredictive sentences, but revealed slowed processing for older adults when context was presented. With the addition of semantic competition to context, older adults were slower to look at the target word after it had been heard. In contrast, offline latency analysis did not show age-related differences in the effects of context and competition. As expected, older adults were generally slower to touch the image than younger adults.

Conclusions
Traditional offline measures were not able to reveal the complex effect of aging on spoken semantic context processing. Online eye gaze measures suggest that older adults were slower than younger adults to predict an indicated object based on semantic context. Semantic competition affected online processing for older adults more than for younger adults, with no accompanying age-related differences in latency. This supports an early age-related inhibition deficit, interfering with processing, and not necessarily with response execution.
Hormonal Contraception. Guideline of the DGGG, OEGGG and SGGG (S3 Level, AWMF Registry Number 015/015, January 2020)
Authors: Franik Sebastian , Bauersachs Rupert , Beyer-Westendorf Jan , Buchholz Tina , Bühling Kai , Diener Hans-Christoph , Erath Anke , Fischer Ronald , Förderreuther Stefanie , Franz Heiko B. G. , Hach-Wunderle Viola , Hadji Peymann , Harlfinger Werner , Jaursch-Hancke Cornelia , König Klaus , Krämer Günter , Naumann Gert , Neulen Joseph , Oppelt Patricia G. , Pliefke Jutta , Rimbach Stefan , Rott Hannelore , Schroll Eckhard , Schumann Claudia , Segerer Sabine , Seyler Helga , Tempfer Clemens , Thonke Ines , Toth Bettina , Wildt Ludwig , Zotz Rainer , Stute Petra , Kiesel Ludwig 
Published: February 2021

Abstract
Aims This is an official interdisciplinary guideline published and coordinated by the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (OEGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The guideline was developed for use in German-speaking regions and is backed by numerous professional societies and organizations. The aim of this guideline is to provide an evidence- and consensus-based overview of the diagnostic approach and the management of hormonal contraception based on a systematic evaluation of the relevant literature.
Methods To compile this S3-guideline, a systematic search for evidence was carried out in PubMed and the Cochrane Library to adapt existing guidelines and identify relevant reviews and meta-analyses. A structured evaluation of the evidence was subsequently carried out on behalf of the Guidelines Commission of the DGGG, and a structured consensus was achieved based on consensus conferences attended by representative members from the different specialist societies and professions.
Recommendations Evidence-based recommendations about the advice given to women requesting contraception were compiled. The guideline particularly focuses on prescribing contraceptives which are appropriate to womenʼs individual needs, take account of her personal circumstances, and have few or no side effects.
Berufsdermatologie: Was ist neu im Jahr 2021?
Authors: Elsner P. 
Published: February 2021

ZusammenfassungZum 01. 01. 2021 tritt eine weitreichende Reform des Berufskrankheitenrechts in Kraft, wonach der sog. „Unterlassungszwang“ als Voraussetzung für die Anerkennung einer Berufskrankheit abgeschafft wird. Die Berufskrankheit (BK) Haut Nr. 5101 wird daher neu definiert als „schwere oder wiederholt rückfällige Hauterkrankungen“; ob die Hauterkrankung zur Unterlassung der hautgefährdenden Tätigkeit zwingt und diese unterlassen wurde oder ob Versicherte ihre Tätigkeit fortführen, ist für die Anerkennung einer BK 5101 nicht mehr von Belang. Sind die Voraussetzungen der Schwere und/oder der wiederholten Rückfälligkeit gegeben, ist eine BK-Anzeige zu erstellen und, nach geplanter Ergänzung des Vertrags Ärzte-Unfallversicherungsträger, gleichzeitig ein Hautarztbericht zu erstatten. Mit einer größeren Zahl anerkannter Fälle einer BK 5101 ist zu rechnen; für diese Versicherten besteht dann ein lebenslanges Anrecht auf die dermatologische Versorgung der BK-Folgen durch die Gesetzliche Unfallversicherung und ggf. auch auf eine Rentenzahlung. Zumindest für die Fälle von leichten beruflichen Hauterkrankungen behält das seit 1972 bewährte Hautarztverfahren weiterhin seine Bedeutung.Keine Änderungen ergeben sich 2021 für die Berufskrankheiten Nr. 5102 (Hautkrebs durch PAK) und 5103 (Plattenepithelkarzinome und multiple aktinische Keratosen durch solare UV-Strahlung). Neue Erkenntnisse ergaben sich jedoch für UV-bedingte Basalzellkarzinome (BZK). In einer jüngst publizierten großen multizentrischen Fall-Kontroll-Studie konnte gezeigt werden, dass bei Personen mit hoher beruflicher UV-Exposition ein mehr als 2-fach signifikant erhöhtes Risiko für BZK an beruflich UV-exponierten Körperlokalisationen besteht. Damit ist für diese Personengruppe das sog. „Verdoppelungsrisiko“ nachgewiesen, und auf der Basis dieser neuen Erkenntnisse ist die Meldung entsprechender Fälle mit einer BK-Anzeige nach § 9 Abs. 2 SGB VII möglich.
Psychosomatic Aspects in Preparation and Follow-Up in Glaucoma Surgery and Their Special Impact on Patients
Authors: Emmerich Gabriele Maria 
Published: February 2021

AbstractGlaucoma patients often bear a long-lasting burden of disease. This can result in anxiety and stress. Causes and effects of anxiety are identified and case studies illustrate how to deal with them. Some knowledge of psychosomatic management is helpful for doctors in dealing with their patients to provide necessary treatment in a less fearful and stressful format.
Effect of Probiotics and Prebiotics on Oral Health
Authors: Nanavati Goutam , Prasanth T. , Kosala Manab , Bhandari Sujit K. , Banotra Pamil 
Published: February 2021

AbstractProbiotics are the living microorganisms that have been commonly used in the prevention of gastrointestinal disorders. In recent times, probiotic and prebiotics have been used to assess and develop a natural balance of the microbial flora in the respiratory tract and the oral cavity as an adjunct therapy. They are known to augment the existing microbial flora that is beneficial to the host. Prebiotics are nondigestible food ingredients that help in increasing populations of probiotic bacteria. Recent studies have shown that probiotics help in active reduction in gingivitis, dental caries, periodontitis, and halitosis by replacing the harmful oral species, by means of utilizing abundant health-associated oral microbial species. Additionally, the nitrate-reducing bacteria have shown promising effect in improving efficiency of probiotic strains to accentuate oral health benefits. Probiotics along with prebiotics effectively alter the host–microbial interface by achieving homeostasis in multifactorial diseases such as periodontal diseases and oral malodor. The aim of the review is to collate the existing information available on use of probiotics and prebiotics in oral cavity.
Protocatechuic Acid Protects Platelets from Apoptosis via Inhibiting Oxidative Stress-Mediated PI3K/Akt/GSK3β Signaling
Authors: Ya Fuli , Li Kongyao , Chen Hong , Tian Zezhong , Fan Die , Shi Yilin , Song Fenglin , Xu Xiping , Ling Wenhua , Adili Reheman , Yang Yan 
Published: February 2021

AbstractOxidative stress plays crucial roles in initiating platelet apoptosis that facilitates the progression of cardiovascular diseases (CVDs). Protocatechuic acid (PCA), a major metabolite of anthocyanin cyanidin-3-O-β-glucoside (Cy-3-g), exerts cardioprotective effects. However, underlying mechanisms responsible for such effects remain unclear. Here, we investigate the effect of PCA on platelet apoptosis and the underlying mechanisms in vitro. Isolated human platelets were treated with hydrogen peroxide (H2O2) to induce apoptosis with or without pretreatment with PCA. We found that PCA dose-dependently inhibited H2O2-induced platelet apoptosis by decreasing the dissipation of mitochondrial membrane potential, activation of caspase-9 and caspase-3, and decreasing phosphatidylserine exposure. Additionally, the distributions of Bax, Bcl-xL, and cytochrome c mediated by H2O2 in the mitochondria and the cytosol were also modulated by PCA treatment. Moreover, the inhibitory effects of PCA on platelet caspase-3 cleavage and phosphatidylserine exposure were mainly mediated by downregulating PI3K/Akt/GSK3β signaling. Furthermore, PCA dose-dependently decreased reactive oxygen species (ROS) generation and the intracellular Ca2+ concentration in platelets in response to H2O2. N-Acetyl cysteine (NAC), a ROS scavenger, markedly abolished H2O2-stimulated PI3K/Akt/GSK3β signaling, caspase-3 activation, and phosphatidylserine exposure. The combination of NAC and PCA did not show significant additive inhibitory effects on PI3K/Akt/GSK3β signaling and platelet apoptosis. Thus, our results suggest that PCA protects platelets from oxidative stress-induced apoptosis through downregulating ROS-mediated PI3K/Akt/GSK3β signaling, which may be responsible for cardioprotective roles of PCA in CVDs.
Assessment of Platelet Thrombus Formation under Flow Conditions in Adult Patients with COVID-19: An Observational Study
Authors: Artoni Andrea , Panigada Mauro , Ghirardello Stefano , Lecchi Anna , Aliberti Stefano , Scalambrino Erica , La Marca Silvia , Boscarino Marco , Gramegna Andrea , Properzi Paolo , Abruzzese Chiara , Blasi Francesco , Grasselli Giacomo , Mosca Fabio , Tripodi Armando , Peyvandi Flora 
Published: February 2021

Abstract
Background Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation, which may dysregulate platelet function. Total Thrombus-Formation Analysis System (T-TAS) is a flow-chamber device that analyses platelet-mediated thrombus formation in capillary channels through the following parameters: (1) the area under the flow-pressure curve (AUC), (2) occlusion start time (OST), time needed to reach OST, and (3) occlusion time (OT), time needed to reach the occlusion pressure.
Methods and Findings Sixty-one COVID-19 patients admitted to intensive, subintensive, and low intensive care were prospectively enrolled according to the time of admission: group A (up to 8 days) (n = 18); group B (from 9 to 21 days) (n = 19), and group C ( > 21 days) (n = 24). T-TAS measurements were performed at enrolment and after 7 days. Median OST was similar among groups. AUC was lower in group A compared to B (p = 0.001) and C (p = 0.033). OT was longer in group A compared to B (p = 0.001) and C (p = 0.028). Platelet count (PC) was higher in group B compared to A (p = 0.024). The linear regression showed that OT and AUC were independent from PC in group A (OT: 0.149 [95% confidence interval [CI]: –0.326 to 0.624], p = 0.513 and AUC: 0.005 [95% CI: –0.008 to 0.017], p = 0,447). In contrast, in group B, PC was associated with OT (–0.019 [–0.028 to 0.008], p = 0.023) and AUC (0.749 [0.358–1.139], p = 0,015), similarly to group C. Conversely, patients with different illness severity had similar T-TAS parameters.
Conclusion COVID-19 patients display an impaired platelet thrombus formation in the early phase of the disease compared to later stages and controls, independently from illness severity.
Sensor Use in Cruciate-Retaining Total Knee Arthroplasty Compared with Posterior-Stabilized Total Knee Arthroplasty: Load Balancing and Posterior Femoral Rollback
Authors: Song Sang Jun , Kim Kang Il , Park Cheol Hee 
Published: February 2021

AbstractThe purpose was to investigate the proportion of severe load imbalance after appropriate conventional gap balancing and analyze the intraoperative kinematics after load balancing in cruciate-retaining (CR) and posterior-stabilized (PS) total knee arthroplasties (TKAs). In total, 45 sensor-assisted CR and 45 PS TKAs using NexGen prosthesis were prospectively evaluated. After appropriate conventional gap balancing, the loads at 10, 45, and 90 degrees of knee flexion were evaluated with a wireless load sensor placed in trial implants. The proportion of severe load imbalance (medial load–lateral load >75 lbs) was investigated. After load balancing, location of the femorotibial contact point was investigated at each flexion angle to analyze femorotibial kinematics. The proportion of the severe load imbalance was significantly higher in CR TKAs at the 10 degrees knee flexion (37.8 vs. 15.6%, p = 0.031). This proportion was higher in CR TKAs than in PS TKAs at the 45 and 90 degrees knee flexion angles, but without statistical significance (31.1 vs. 15.6%, p = 0.134 and 33.3 vs. 15.6%, p = 0.085, respectively). After load balancing, consistent posterior femoral rollback occurred in medial and lateral compartments during 90 degrees flexion in CR TKAs (p < 0.001), but not in PS TKAs. Medial pivot kinematics was not observed in both TKA designs. The sensor was more beneficial in CR TKAs for achieving appropriate load balancing and consistent posterior femoral rollback compared with PS TKAs. Further studies are required to identify target load distribution to restore ideal knee kinematics after TKA. This study shows level of evidence II.
Complications Associated with Posterior Cruciate Ligament Reconstruction and Avoiding Them
Authors: James Evan W. , Taber Caroline E. , Marx Robert G. 
Published: February 2021

AbstractPosterior cruciate ligament (PCL) injuries often occur as part of a multiligament injury pattern and can present a significant challenge to the treating surgeon. When PCL reconstruction is indicated, complications can arise in the intraoperative and postoperative period that lead to poor outcomes. These complications include neurovascular injury, fracture, compartment syndrome, persistent posterior laxity, motion loss, residual knee pain, osteonecrosis, and heterotopic ossification. The purpose of this review is to highlight complications associated with PCL reconstruction and strategies to avoid them.
Preoperative Factors Associated with 2-Year Postoperative Survey Completion in Knee Surgery Patients
Authors: Kadiyala Jagannath , Zhang Tina , Aneizi Ali , Gopinath Rohan , Ventimiglia Dominic J. , Burt Cameran I. , Sajak Patrick M.J. , Meredith Sean J. , Henn R. Frank 
Published: February 2021

AbstractPatient-reported outcomes, such as the Patient-Reported Outcomes Measurement Information System (PROMIS) measures, have become increasingly valued as measures of treatment. The purpose of the study was to determine preoperative factors associated with survey compliance 2 years after elective knee surgery. Five hundred patients, age 17 years and older, undergoing knee surgery from August 2015 and March 2017 were administered questionnaires preoperatively and 2 years postoperatively. Questionnaires included the International Knee Documentation Committee (IKDC) score, Numeric Pain Scales (NPS), International Physical Activity Questionnaire (IPAQ), and six PROMIS Domains for physical function, pain interference, social satisfaction, fatigue, anxiety, and depression. Three hundred sixty-five patients (73.0%) completed both the preoperative and the 2-year surveys. A decreased likelihood of survey completion was significantly associated with black race, lower income, government-sponsored insurance, smoking, opioid use, fewer previous surgeries, lower expectations, lower PROMIS social satisfaction, higher PROMIS pain interference, and lower IPAQ physical activity. Multivariable logistic regression analysis confirmed that black race and lower IPAQ activity level were independent predictors of lower survey completion at 2-year follow-up with an area under the curve (AUC) of 0.62. A more robust multivariable model that included all variables with p < 0.05 in the bivariate analysis had an AUC of only 0.70. This study identified multiple preoperative factors that were associated with lower survey completion 2 years after elective orthopaedic knee surgery; however, all the factors measured in this study were not strong predictors of survey completion.
Pressure-assisted fabrication of perovskite light emitting devices
Authors: Adeniji S. A. , Cromwell J. , Oyewole D. O. , Oyelade O. V. , Koech R. K. , Sanni D. M. , Oyewole O. K. , Babatope B. , Soboyejo W. O. 
Published: February 2021

This paper presents the results of pressure-effects on performance characteristics of near-infra-red perovskite light emitting diodes (PeLEDs) using a combination of experimental and analytical/computational approaches. First, pressure-effects are studied using models that consider the deformation and contacts that occur around interfacial impurities and interlayer surface roughness in PeLEDs. The predictions from the model show that the sizes of the interfacial defects decrease with increasing applied pressure. The current–voltage characteristics of the fabricated devices are also presented. These show that the PeLEDs have reduced turn-on voltages (from 2.5 V to 1.5 V) with the application of pressure. The associated pressure-induced reductions in the defect density and the bandgaps of the perovskite layer are then used to explain the improved performance characteristics of the PeLED devices.
Electro-permanent magnetic weight release mechanism for buoyancy control of an autonomous well-logging tool
Authors: Seren Huseyin R. , Buzi Erjola , Deffenbaugh Max 
Published: February 2021

We present the design and test of a magnetic actuator that is used to hold and release a ballast and switch buoyancy of a miniaturized autonomous well-logging tool from negative to positive. The actuator makes use of a low coercivity aluminum-nickel-cobalt (AlNiCo) magnet paired with a high coercivity neodymium-iron-boron (NIB) magnet to create and cancel a magnetic pull force on a steel plate by changing the polarization direction of the former magnet. Brief current pulses sent through a solenoid wrapped around the AlNiCo magnet by charging and discharging a capacitor. The resulting resistor-inductor-capacitor (RLC) circuit is analyzed to understand the polarization process of the AlNiCo magnet and state change of the actuator’s pull force. Our numerical solution using a nonlinear inductor model and test results showed that the repolarization can be achieved in steps using a relatively small 0.1 mF capacitor thanks to stored remnant field at each step. This made it possible to save space and energy for the miniaturized autonomous logging tool. Effects of NIB and steel weight piece on the AlNiCo polarization are experimentally analyzed. Magnetic circuit geometry is optimized using finite element analysis to maximize the pull force on the weight. The actuator occupies less than 2 cm3 and provides more than 2 kg-f to carry a ballast that weighs about 60 grams.
The role of double-diffusive convection in basal melting of Antarctic ice shelves
Authors: Rosevear Madelaine Gamble , Gayen Bishakhdatta , Galton-Fenzi Benjamin Keith 
Published: February 2021

Significance
Ocean-driven melting of ice shelves is a leading cause of mass loss from Antarctica. However, the small-scale ocean processes responsible for melting are poorly understood due to the difficulty of making direct measurements in these hard to reach environments. Here, we use a high-resolution ocean model to fill this knowledge gap. At low current speeds and relatively warm ocean temperatures, we show that a small-scale ocean process called double-diffusive convection controls ice shelf melt rates and turbulent mixing, forming a unique “staircase” structure beneath the ice. This process is currently missing from ocean–climate models, which consider only turbulent melting due to ocean currents.
Neural divergence and hybrid disruption between ecologically isolatedHeliconiusbutterflies
Authors: Montgomery Stephen H. , Rossi Matteo , McMillan W. Owen , Merrill Richard M. 
Published: February 2021

SignificanceAlthough previous studies highlight the importance of ecological variation in driving divergence in brain morphology, whether these changes accumulate after ecological transitions or play a significant role in facilitating them is unclear. We show that divergent selection associated with microhabitat partitioning drove heritable divergence in brain composition and neural gene expression between sister clades ofHeliconiusbutterflies. Neuroanatomical divergence is restricted to visual structures and reflect adaptations to contrasting sensory niches. We show how divergent neural traits can act as barriers to gene flow by demonstrating that hybrids have intermediate traits and by presenting evidence that genes with adaptive patterns of expression divergence are more likely to occur in regions of the genome that are resistant to interspecific gene flow.
The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization
Authors: Xiao Tiaojiang , Li Xin , Felsenfeld Gary 
Published: February 2021

SignificanceThe protein CTCF plays a major role in large-scale organization of the genome. Binding sites for the protein MAZ are found adjacent to many CTCF sites. We show that, at such double sites, MAZ stabilizes CTCF binding. MAZ, like CTCF, acts independently as an “insulator” element to block the effects of a distal enhancer on a promoter, and, like CTCF, it can block the advance of a transcribing RNA polymerase II, leading to alternative RNA splicing patterns. Depletion of MAZ causes loss of short-range interactions within the nucleus and disruption of some longer-range interactions. Thus, MAZ plays a complementary role to CTCF in the nucleus, enhancing the organizational properties of CTCF and displaying many functions related to genome organization.
Spin stiffness of chromium-based van der Waals ferromagnets
Authors: Shu Zhixue , Kong Tai 
Published: February 2021

Abstract
Low temperature magnetization of CrI3, CrSiTe3 and CrGeTe3 single crystals were systematically studied. Based on the temperature dependence of extrapolated spontaneous magnetization from magnetic isotherms measured at different temperatures, the spin stiffness constant (D) and spin excitation gap (Δ) were extracted according to Bloch’s law. For spin stiffness, D is estimated to be 27 ± 6 meV Å2, 20 ± 3 meV Å2 and 38 ± 7 meV Å2 for CrI3, CrSiTe3 and CrGeTe3 respectively. Spin excitation gaps determined via Bloch’s formulation have larger error bars yielding 0.59 ± 0.34 meV (CrI3), 0.37 ± 0.22 meV (CrSiTe3) and 0.28 ± 0.19 meV (CrGeTe3). Among all three studied compounds, larger spin stiffness value leads to higher ferromagnetic transition temperature.