bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Quality‐of‐Life Improvements Following Global Head and Neck Surgery Trips to Underserved Regions
Authors: Panuganti Bharat A. , Jafari Aria , Shen Sarek , Qualliotine Jesse R. , Schueth Elizabeth A. , Campbell Bruce , Ngoitsi Henry , Cordes Susan 
Published: March 2021

Objectives/HypothesisTo conduct longitudinal postoperative follow‐up and discern health‐related quality‐of‐life (HR‐QoL) changes using a validated questionnaire among patients undergoing head and neck surgeries during a short‐term, global surgical trip in a resource‐limited setting. To identify clinicodemographic predictors of post‐operative HR‐QoL improvements in this setting.Study DesignRetrospective observational study with prospective follow‐up.MethodsPatients undergoing surgery at Moi Teaching and Referral Hospital in Eldoret, Kenya through the authors' short‐term surgical trip (STST) between 2016 and 2019 were asked to complete preoperative Short Form‐36 (SF‐36) HR‐QoL questionnaires, and postoperative SF‐36 questionnaires during subsequent follow‐up. Preoperative and postoperative SF‐36 domain scores, and two composite scores (mental component summary [MCS] and physical component summary [PCS]) were compared. Linear regression models were fit to identify clinicodemographic factors predictors of general health (GH), MCS, and PCS scores.ResultsAmong the 26 participating patients, significant improvements were seen in post‐operative GH (mean change = 19.8) and MCS (mean change = 11.2) scores. Lower pre‐operative GH, MCS, and PCS scores were predictive of greater improvement in the corresponding post‐operative scores. Longer time to follow‐up was associated with greater improvement in GH score. Mean follow‐up interval was 23.1 months (SD = 1.8 months).ConclusionsUtilizing the SF‐36 questionnaire, we found that patients' perception of their general and psychosocial health improved after undergoing head and neck surgeries through a global STST. This study provides important, preliminary evidence that that elective surgeries performed in low‐resource settings convey substantial benefit to patient QoL.Level of Evidence4 Laryngoscope, 131:2006–2010, 2021
Circulator‐Free Brillouin Photonic Planar Circuit
Authors: Liu Yang , Choudhary Amol , Ren Guanghui , Choi Duk‐Yong , Casas‐Bedoya Alvaro , Morrison Blair , Ma Pan , Nguyen Thach G. , Mitchell Arnan , Madden Stephen J. , Marpaung David , Eggleton Benjamin J. 
Published: March 2021

AbstractOn‐chip stimulated Brillouin scattering (SBS) that results from enhanced light–sound interactions, has recently demonstrated great applicability and versatility for signal generation and manipulation. Progress toward realizing fully integrated Brillouin photonic circuits is promising; however, the control and routing of on‐chip optical waves requires non‐reciprocal elements such as circulators, which is challenging and adds complexity. Here, a circulator‐free Brillouin photonic planar waveguide circuit which eliminates the need for separate non‐reciprocal elements is demonstrated. Backward inter‐modal Brillouin scattering (BIBS) is used in a planar photonic integrated circuit, for the first time, to provide Brillouin processing capability in a multi‐modal waveguide, conveniently allowing for the separation of counter‐propagating pump and signal using passive integrated mode‐selective filters. Using an As2S3–Si hybrid multi‐modal photonic circuit, inter‐optical‐mode energy transfer with a Brillouin gain coefficient of 280 m−1W−1 is experimentally demonstrated, representing two orders of magnitude enhancement compared to conventional optical fibers. This on‐chip BIBS circuit allows for independent routing of pump and signal waves, showing resilience to the cross talk. The experimental demonstrations provide an important basis for achieving fully integrated Brillouin photonic circuits without requiring on‐chip circulators and fine spectral filtering, opening a new dimension for studying spatial‐dependent photon–phonon nonlinear dynamics.
Conformally Mapped Mikaelian Lens for Broadband Achromatic High Resolution Focusing
Authors: Chen Jin , Chu Hong Chen , Lai Yun , Liu Zhanwei , Chen Huanyang , Chen Mingji , Fang Daining 
Published: March 2021

AbstractFocusing light into a tiny spot of high resolution is of significant importance in fields from imaging, photolithography to microwave engineering and sensing. However, most of the previous high resolution metalenses are constrained by their limited bandwidth and efficiency. In this paper, on the basis of Mikaelian lens derived from conformal transformation optics, a rectangular gradient refractive index lens with a relatively larger refractive index profile is put forward and manufactured by gradient isotropic dielectrics. Highly efficient (above 74%) broadband (7–14 GHz) achromatic high resolution focusing with full width at half maximum (FWHM) around 0.2λ as well as large numerical aperture (NA) of 2.04 has been accomplished. Measured results agree well with theoretical predictions, which makes the presented lens having a great potential to be employed in high resolution imaging systems.
Methodological structure for future consumer neuroscience research
Authors: He Lin , Freudenreich Thomas , Yu Wenhuan , Pelowski Matthew , Liu Tao 
Published: March 2021

AbstractConsumer neuroscience—as a valuable complement to traditional, largely behavioral, research methods—is attracting increasing interest from researchers of marketing and consumer behavior. Although this field has made very important contributions, most consumer neuroscience studies to date have mainly focused on individuals' brain responses to simple marketing stimuli in solitary, lab‐based, albeit well‐controlled, experimental settings. Thus, previous studies may not yet have tapped other promising approaches involving more ecologically valid, “real,” or social consumption experiences, which could add key extensions to past methods and results. This paper summarizes current findings of consumer neuroscience, including a brief overview of past approaches and topics of focus, and then more expansively targeting these emerging approaches, and proposes a methodological structure for future research emphasizing a movement from a single‐brain frame, in which single individuals passively observe and respond to marketing stimuli, to also multibrain perspectives, where group of consumers actively engage in consumption activities. Accordingly, a three‐layer approach to analysis is suggested, emphasizing not only (1) activation patterns and brain regions but also directed (2) intra‐ and inter‐brain networks with (3) dynamic processing. This review provides an important next step in the understanding of neural cognitive mechanisms underlying consumer behavior.
Adaptive weighted 61‐QAM based on geometric shaping in coherent optical communication utilizing K‐Means algorithm
Authors: Zhou Wenmao , Zhang Qi , Gao Ran , Wang Xishuo , Xin Xiangjun , Li Xiangpeng , Tian Qinghua , Tian Feng , Wang Yongjun 
Published: March 2021

AbstractA novel adaptive weighted geometric‐shaped (GS) 61 quadrature amplitude modulation (QAM) constellation is proposed in order to mitigate the nonlinear damage and increase the transmission distance. By introducing an adaptive weighting factor related to Kerr effect and fiber transmission distance in concentric regular hexagon constellation, the overlapping problem of the outer constellation points induced by nonlinear damage was reduced. The simulation results show that the proposed GS‐61QAM outperformed uniform 64QAM and has more obvious advantages in long‐haul optical transmission system. For a 120‐Gb/s coherent optical communication system, compared with uniform 64QAM, the proposed algorithm can obtain about 4.1 dB optical signal‐to‐noise (OSNR) gain at the BER of 10−2. Moreover, in order to further improve the system tolerance of nonlinearity, a scheme of adaptive weighted GS‐61QAM in coherent optical communication system utilizing K‐Means algorithm is proposed, the proposed scheme outperforms the traditional uniform 64QAM communication system by 5 dB in OSNR at the BER of 10−2.
Accelerated multicontrast reconstruction for synthetic MRI using joint parallel imaging and variable splitting networks
Authors: Ryu Kanghyun , Lee Jae‐Hun , Nam Yoonho , Gho Sung‐Min , Kim Ho‐Sung , Kim Dong‐Hyun 
Published: March 2021

PurposeSynthetic magnetic resonance imaging (MRI) requires the acquisition of multicontrast images to estimate quantitative parameter maps, such as T1, T2, and proton density (PD). The study aims to develop a multicontrast reconstruction method based on joint parallel imaging (JPI) and joint deep learning (JDL) to enable further acceleration of synthetic MRI.MethodsThe JPI and JDL methods are extended and combined to improve reconstruction for better‐quality, synthesized images. JPI is performed as a first step to estimate the missing k‐space lines, and JDL is then performed to correct and refine the previous estimate with a trained neural network. For the JDL architecture, the original variable splitting network (VS‐Net) is modified and extended to form a joint variable splitting network (JVS‐Net) to apply to multicontrast reconstructions. The proposed method is designed and tested for multidynamic multiecho (MDME) images with Cartesian uniform under‐sampling using acceleration factors between 4 and 8.ResultsIt is demonstrated that the normalized root‐mean‐square error (nRMSE) is lower and the structural similarity index measure (SSIM) values are higher with the proposed method compared to both the JPI and JDL methods individually. The method also demonstrates the potential to produce a set of synthesized contrast‐weighted images that closely resemble those from the fully sampled acquisition without erroneous artifacts.ConclusionCombining JPI and JDL enables the reconstruction of highly accelerated synthetic MRIs.
Patient knowledge of rotator cuff related shoulder pain condition and treatment and validation of a patient‐reported knowledge questionnaire
Authors: Phillips Rebecca , Perraton Luke , Cridland Kate , Maloney Stephen , Harris Ian A. , Malliaras Peter 
Published: March 2021

AbstractBackgroundRotator cuff related shoulder pain (RCRSP) knowledge is an important contributor to compliance with clinical practice guidelines and providing best practice care. However, there are no validated instruments for measuring health literacy levels among people with RCRSP. This study aimed to design a valid and reliable instrument to measure RCRSP health literacy and use it to evaluate an education intervention for people with RCRSP.MethodsDevelopment of the patient knowledge questionnaire (PKQ‐RCRSP) included three phases. Phase 1 was developed based on available literature and input from expert clinicians, researchers and patients. Face validity, pilot testing and readability assessment were also undertaken. In Phase 2, internal consistency and predictive validity were assessed in people with RCRSP and other shoulder pain diagnoses. In Phase 3, RCRSP health literacy was assessed.ResultFace validity was acceptable and pilot testing identified minor accuracy issues that were corrected. Literacy level was rated as ‘difficult to read’ which reflects the medical terminology within the questionnaire. Internal consistency was very good and 81% of questions demonstrated acceptable predictive validity. Health literacy was heterogeneous depending on the question with less than 40% of respondents answering correctly for questions related to the indications, process and the known benefits of RCRSP surgery.ConclusionThe PKQ‐RCRSP demonstrated acceptable face validity, predictive validity and reliability (internal consistency) in assessing RCRSP health literacy. Health literacy among our small sample was poor for questions related to surgery for RCRSP.
The evolution and utilization of telehealth in ambulatory nutrition practice
Authors: Shah Neha D. , Krupinski Elizabeth A. , Bernard Jordana , Moyer Meagan F. 
Published: March 2021

AbstractThe term telehealth is often used interchangeably with telemedicine. Telemedicine involves the electronic exchange of medical information between two remote sites for the optimization of patient care, whereas telehealth is the application of all electronic communication and delivery systems in the provision of healthcare. Telehealth gives patients an opportunity to communicate with their healthcare providers and, overall, access ambulatory care that otherwise is not available in their area of residence. Several telehealth delivery systems are available for electronic communication. Telehealth and other communications technologies used in the delivery of healthcare services are regulated at both the federal and state levels. Coverage and payment policies vary among the different insurers (e.g., Medicare, Medicaid, and private plans), and policies may further be defined by state telehealth parity laws. Telenutrition involves the use of digital technology to provide nutrition care to patients and caregivers and shows potential to optimize nutrition care and outcomes. The coronavirus disease 2019 pandemic has contributed to sweeping legislative and regulatory changes that allowed the temporary expansion of telehealth delivery and reimbursement to maintain continuity of care for patients who were not able to come in for an in‐person office visit with their healthcare provider. The purpose of this review is to introduce key concepts of telehealth delivery systems including policy, legal, and regulatory considerations for ambulatory care as well as the role of telenutrition in nutrition care, and highlight the evolving role of telehealth in optimizing patient and nutrition care during a pandemic and beyond.
Chronic Kidney Disease and Nutrition Support
Authors: Chan Winnie 
Published: March 2021

AbstractIndividuals with chronic kidney disease (CKD), particularly those undergoing maintenance dialysis, are prone to protein‐energy wasting (PEW), the latter of which can be ameliorated with different methods of nutrition support. Dietary counseling guided by dietitians is the key for preventing and managing PEW in CKD. If dietary counseling per se fails to meet the recommended energy and protein requirements, the addition of oral nutrition supplements (ONSs) would be necessary. When these initial measures cannot attain the recommended energy and protein requirements, nutrition support, including enteral tube feeding or parenteral nutrition (PN), should be considered as a viable option to improve nutrition status. Partial PN, comprising intraperitoneal PN (IPPN) and intradialytic PN (IDPN) therapies, may be attempted as supplemental nutrition support in patients with PEW requiring peritoneal dialysis and hemodialysis, respectively. Despite the debatable effectiveness of IPPN for patients undergoing peritoneal dialysis, it remains a feasible means in these patients. The indications for IPPN in patients undergoing peritoneal dialysis include inadequate dietary intake of energy and protein, and barriers of oral intake and other forms of enteral supplementation such as issues with suitability, tolerance, and compliance. Nonetheless, in the case of spontaneous dietary consumption of energy and protein meeting the difference between the IDPN provision and the nutrition targets, the use of IDPN is rational. In patients with PEW and malfunctioning gastrointestinal tract, as well as those whose enteral intake (with or without partial PN) is below the recommended nutrient requirements, total PN becomes a relevant nutrition intervention.
Combining label‐free and label‐based accurate quantifications with SWATH‐MS: Comparison with SRM and PRM for the evaluation of bovine muscle type effects
Authors: Bons Joanna , Husson Gauthier , Chion Marie , Bonnet Muriel , Maumy‐Bertrand Myriam , Delalande François , Cianférani Sarah , Bertrand Frédéric , Picard Brigitte , Carapito Christine 
Published: March 2021

AbstractMass spectrometry has proven to be a valuable tool for the accurate quantification of proteins. In this study, the performances of three targeted approaches, namely selected reaction monitoring (SRM), parallel reaction monitoring (PRM) and sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH‐MS), to accurately quantify ten potential biomarkers of beef meat tenderness or marbling in a cohort of 64 muscle samples were evaluated. So as to get the most benefit out of the complete MS2 maps that are acquired in SWATH‐MS, an original label‐free quantification method to estimate protein amounts using an I‐spline regression model was developed. Overall, SWATH‐MS outperformed SRM in terms of sensitivity and dynamic range, while PRM still performed the best, and all three strategies showed similar quantification accuracies and precisions for the absolute quantification of targets of interest. This targeted picture was extended by 585 additional proteins for which amounts were estimated using the label‐free approach on SWATH‐MS; thus, offering a more global profiling of muscle proteomes and further insights into muscle type effect on candidate biomarkers of beef meat qualities as well as muscle metabolism.
Custom NIR Imaging of New Up‐Conversion Multimodal Gadolinium Oxysulfide Nanoparticles
Authors: Santelli Julien , Lepoix Carole , Lechevallier Séverine , Martinez Cyril , Calise Denis , Zou Qilin , Moyano Sebastien , Cussac Daniel , Verelst Marc , Mauricot Robert 
Published: March 2021

AbstractUp‐conversion (UC) nanoparticles (NPs) appear as promising probes for easy, cost‐effective, and efficient in vivo imaging. In this paper, a new kind of UCNPs is proposed: Gd2O2S:Yb3+/Tm3+ for multimodal bioimaging, exhibiting a strong fluorescent emission in the near‐infrared range (802 nm) when excited at 980 nm. The in vivo fluorescence detection of such NPs is made possible by the development of a dedicated custom‐made imaging system. However, the high sensitivity of the techniques is counterbalanced with a limited resolution which highlights the necessity of combining different approaches to gather as much vital information as possible. The presence of a large amount of gadolinium also confers interesting contrasting properties both in magnetic resonance imaging (MRI) and computed tomography (CT) that could be advantageously exploited in the context of multimodal in vivo imaging. In this study, the UC emission properties and energy transfer processes of this new nanoprobe are reported. The detectability of the UCNPs is exhibited using the custom‐made imaging system in different tissues (skin, muscle, kidney, liver, brain), depths (different anatomical localization), and species (rat and mouse), punctually and chronically. Last, promising multimodal bioimaging results are presented in UC, MRI, and CT, showing a relatively low detection threshold.
Preparation of Microspherical Ph−Fe/RDX(HMX) Composite Particles and their Thermal Decomposition Behaviors
Authors: Song Naimeng , Yang Li , Liu Pingan 
Published: March 2021

AbstractThis paper mainly introduces the Ph−Fe/RDX(HMX) composite microspheres prepared by ultrasonic spray drying. Their morphology was observed by SEM and found that the composite microspheres were spherical. Also, the composite microspheres exhibited good dispersion. The results of the granularity data show that the D50 data of Ph−Fe/RDX and Ph−Fe/HMX were 580.78 nm and 496.52 nm, respectively. The DSC data showed that the catalytic effect of the composite microspheres was significantly better than that of the mixed powder. The DSC data showed that the decomposition peak temperature of the Ph−Fe/RDX(HMX) composite microsphere was 229.6 °C (279.6) lower than the 235.6 °C (284.3) of the mixed powder. The DSC data demonstrated that the catalytic performance of the composite microspheres was significantly better than that of the mixed powder. Therefore, the ultrasonic spray drying method has great potential for preparing energetic composite microspheres.
Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF‐1 upregulation of TUBB2B beta‐tubulin isoform
Authors: Liotti Antonietta , La Civita Evelina , Cennamo Michele , Crocetto Felice , Ferro Matteo , Guadagno Elia , Insabato Luigi , Imbimbo Ciro , Palmieri Alessandro , Mirone Vincenzo , Liguoro Pasquale , Formisano Pietro , Beguinot Francesco , Terracciano Daniela 
Published: March 2021

AbstractGrowing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect response to Docetaxel (DCTX) and the mechanisms associated. Conditioned medium was collected from the in vitro differentiated adipocytes isolated from PPAT which was isolated from PCa patients, during radical prostatectomy. Drug efficacy was studied by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide citotoxicity assay. Culture with CM of human PPAT (AdipoCM) promotes DCTX resistance in two different human prostate cancer cell lines (DU145 and PC3) and upregulated the expression of BCL‐xL, BCL‐2, and TUBB2B. AG1024, a well‐known IGF‐1 receptor inhibitor, counteracts the decreased response to DCTX observed in presence of AdipoCM and decreased TUBB2B expression, suggesting that a paracrine secretion of IGF‐1 by PPAT affect DCTX response of PCa cell. Collectively, our study showed that factors secreted by PPAT elicits DCTX resistance through antiapoptotic proteins and TUBB2B upregulation in androgen independent PCa cell lines. These findings reveal the potential of novel therapeutic strategies targeting adipocyte‐released factors and IGF‐1 axis to overcome DCTX resistance in patients with PCa.
Identification of new biomarkers for sarcopenia and characterization of cathepsin D biomarker
Authors: L'hôte Corine , Cordier Benoît , Labasse Alain , Boileau Christelle , Costes Bérénice , Henrotin Yves 
Published: March 2021

AbstractBackgroundSarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function that occurs with aging. This study was undertaken to identify new biomarkers of sarcopenia by proteomics analysis of female sera.MethodsA case–control study was set up, for which 19 sarcopenic subjects and 20 control subjects, according to the European Working Group on Sarcopenia Older People criteria published in 2010 (EWGSOP1), were enrolled. All the subjects were at least 65 years old and in majority female. Biomarker screening was performed by a comparative mass spectrometry analysis. Protein expression levels between the two groups were compared. One of the identified biomarkers, cathepsin D, was measured by immunoassay on the serum of the full sample set (n = 39). Its diagnostic performance was evaluated with a receiver operating characteristic curve (ROC curve).ResultsTwo biomarkers were identified: fructose‐biphosphate aldolase A (P ≤ 0.05) and cathepsin D (P ≤ 0.05). The levels of all of them were higher in sarcopenic patients. It was confirmed by immunoassay that cathepsin D levels in serum were significantly higher in the sarcopenic group of patients (P = 0.038). An inverse correlation (−0.385) was observed between cathepsin D levels in serum and gait speed. The area under the ROC curve measurement (AUC = 0.696) demonstrated that cathepsin D levels could discriminate between sarcopenic and non‐sarcopenic subjects. A predictive model including cathepsin D, age, and body mass index was established to improve the diagnostic performance (AUC = 0.908).ConclusionsCathepsin D has been identified as a diagnostic biomarker of sarcopenia.