bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust all-optical single-shot readout of nitrogen-vacancy centers in diamond
Authors: Irber Dominik M. , Poggiali Francesco , Kong Fei , Kieschnick Michael , Lühmann Tobias , Kwiatkowski Damian , Meijer Jan , Du Jiangfeng , Shi Fazhan , Reinhard Friedemann 
Published: January 2021

AbstractHigh-fidelity projective readout of a qubit’s state in a single experimental repetition is a prerequisite for various quantum protocols of sensing and computing. Achieving single-shot readout is challenging for solid-state qubits. For Nitrogen-Vacancy (NV) centers in diamond, it has been realized using nuclear memories or resonant excitation at cryogenic temperature. All of these existing approaches have stringent experimental demands. In particular, they require a high efficiency of photon collection, such as immersion optics or all-diamond micro-optics. For some of the most relevant applications, such as shallow implanted NV centers in a cryogenic environment, these tools are unavailable. Here we demonstrate an all-optical spin readout scheme that achieves single-shot fidelity even if photon collection is poor (delivering less than 103 clicks/second). The scheme is based on spin-dependent resonant excitation at cryogenic temperature combined with spin-to-charge conversion, mapping the fragile electron spin states to the stable charge states. We prove this technique to work on shallow implanted NV centers, as they are required for sensing and scalable NV-based quantum registers.
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
Authors: Mok Sachel , Stokes Barbara H. , Gnädig Nina F. , Ross Leila S. , Yeo Tomas , Amaratunga Chanaki , Allman Erik , Solyakov Lev , Bottrill Andrew R. , Tripathi Jaishree , Fairhurst Rick M. , Llinás Manuel , Bozdech Zbynek , Tobin Andrew B. , Fidock David A. 
Published: January 2021

AbstractThe emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, and metabolomics to a panel of isogenic K13 mutant or wild-type P. falciparum lines, we provide evidence that K13 mutations alter multiple aspects of the parasite’s intra-erythrocytic developmental program. These changes impact cell-cycle periodicity, the unfolded protein response, protein degradation, vesicular trafficking, and mitochondrial metabolism. K13-mediated artemisinin resistance in the Cambodian Cam3.II line was reversed by atovaquone, a mitochondrial electron transport chain inhibitor. These results suggest that mitochondrial processes including damage sensing and anti-oxidant properties might augment the ability of mutant K13 to protect P. falciparum against artemisinin action by helping these parasites undergo temporary quiescence and accelerated growth recovery post drug elimination.
Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes
Authors: Simon-Soro Aurea , Kim Dongyeop , Li Yong , Liu Yuan , Ito Tatsuro , Sims Kenneth R. , Benoit Danielle S. W. , Bittinger Kyle , Koo Hyun 
Published: January 2021

AbstractDrug repurposing is a feasible strategy for the development of novel therapeutic applications. However, its potential use for oral treatments and impact on host microbiota remain underexplored. Here, we assessed the influences of topical oral applications of a repurposed FDA-approved drug, thonzonium bromide, on gastrointestinal microbiomes and host tissues in a rat model of dental caries designed to reduce cross-contamination associated with coprophagy. Using this model, we recapitulated the body site microbiota that mirrored the human microbiome profile. Oral microbiota was perturbed by the treatments with specific disruption of Rothia and Veillonella without affecting the global composition of the fecal microbiome. However, disturbances in the oral-gut microbial interactions were identified using nestedness and machine learning, showing increased sharing of oral taxon Sutterella in the gut microbiota. Host-tissue analyses revealed caries reduction on teeth by thonzonium bromide without cytotoxic effects, indicating bioactivity and biocompatibility when used orally. Altogether, we demonstrate how an oral treatment using a repurposed drug causes localized microbial disturbances and therapeutic effects while promoting turnover of specific oral species in the lower gut in vivo.
Neural network reactive force field for C, H, N, and O systems
Authors: Yoo Pilsun , Sakano Michael , Desai Saaketh , Islam Md Mahbubul , Liao Peilin , Strachan Alejandro 
Published: January 2021

AbstractReactive force fields have enabled an atomic level description of a wide range of phenomena, from chemistry at extreme conditions to the operation of electrochemical devices and catalysis. While significant insight and semi-quantitative understanding have been drawn from such work, the accuracy of reactive force fields limits quantitative predictions. We developed a neural network reactive force field (NNRF) for CHNO systems to describe the decomposition and reaction of the high-energy nitramine 1,3,5-trinitroperhydro-1,3,5-triazine (RDX). NNRF was trained using energies and forces of a total of 3100 molecules (11,941 geometries) and 15 condensed matter systems (32,973 geometries) obtained from density functional theory calculations with semi-empirical corrections to dispersion interactions. The training set is generated via a semi-automated iterative procedure that enables refinement of the NNRF until a desired accuracy is attained. The root mean square (RMS) error of NNRF on a testing set of configurations describing the reaction of RDX is one order of magnitude lower than current state of the art potentials.
Metal-to-insulator transition in Pt-doped TiSe2 driven by emergent network of narrow transport channels
Authors: Lee Kyungmin , Choe Jesse , Iaia Davide , Li Juqiang , Zhao Junjing , Shi Ming , Ma Junzhang , Yao Mengyu , Wang Zhenyu , Huang Chien-Lung , Ochi Masayuki , Arita Ryotaro , Chatterjee Utpal , Morosan Emilia , Madhavan Vidya , Trivedi Nandini 
Published: January 2021

AbstractMetal-to-insulator transitions (MIT) can be driven by a number of different mechanisms, each resulting in a different type of insulator—Change in chemical potential can induce a transition from a metal to a band insulator; strong correlations can drive a metal into a Mott insulator with an energy gap; an Anderson transition, on the other hand, due to disorder leads to a localized insulator without a gap in the spectrum. Here, we report the discovery of an alternative route for MIT driven by the creation of a network of narrow channels. Transport data on Pt substituted for Ti in 1T-TiSe2 shows a dramatic increase of resistivity by five orders of magnitude for few % of Pt substitution, with a power-law dependence of the temperature-dependent resistivity ρ(T). Our scanning tunneling microscopy data show that Pt induces an irregular network of nanometer-thick domain walls (DWs) of charge density wave (CDW) order, which pull charge carriers out of the bulk and into the DWs. While the CDW domains are gapped, the charges confined to the narrow DWs interact strongly, with pseudogap-like suppression in the local density of states, even when they were weakly interacting in the bulk, and scatter at the DW network interconnects thereby generating the highly resistive state. Angle-resolved photoemission spectroscopy spectra exhibit pseudogap behavior corroborating the spatial coexistence of gapped domains and narrow domain walls with excess charge carriers.
A dynamic multi-tissue model to study human metabolism
Authors: Martins Conde Patricia , Pfau Thomas , Pires Pacheco Maria , Sauter Thomas 
Published: January 2021

AbstractMetabolic modeling enables the study of human metabolism in healthy and in diseased conditions, e.g., the prediction of new drug targets and biomarkers for metabolic diseases. To accurately describe blood and urine metabolite dynamics, the integration of multiple metabolically active tissues is necessary. We developed a dynamic multi-tissue model, which recapitulates key properties of human metabolism at the molecular and physiological level based on the integration of transcriptomics data. It enables the simulation of the dynamics of intra-cellular and extra-cellular metabolites at the genome scale. The predictive capacity of the model is shown through the accurate simulation of different healthy conditions (i.e., during fasting, while consuming meals or during exercise), and the prediction of biomarkers for a set of Inborn Errors of Metabolism with a precision of 83%. This novel approach is useful to prioritize new biomarkers for many metabolic diseases, as well as for the integration of various types of personal omics data, towards the personalized analysis of blood and urine metabolites.
Enhancing removal efficiency of anionic dye (Cibacron blue) using waste potato peels powder
Authors: Bouhadjra Kahina , Lemlikchi Wahiba , Ferhati Azedine , Mignard Samuel 
Published: January 2021

AbstractIn the present study, the potato peel waste (PP) was used for the removal of the anionic dye Cibacron Blue P3R from an aqueous solution, activated with phosphoric acid (PPa) and calcined at 800 °C (PPc). The materials were characterized by Scanning Electron Microscope, Energy dispersive X-ray analysis and Fourier Transform Infrared Spectroscopy. The effects of various experimental parameters (pH, dye concentration, contact time) were also studied. The experimental results have shown that PPc has a greater capacity compared to pp and ppa. The capacity of PP bio-char (PPc) is 270.3 mg g−1 compared to PP (100 mg g−1) and PPa (125 mg g−1). Equilibrium experiments at 180 min for all materials were carried out at optimum pH (2.2): 76.41, 88.6 and 94% for PP, PPa and PPc respectively; and the Langmuir models agreed very well with experimental data. The ability of sorbent for the sorption of CB dye follows this order: calcined > activated > native materials. Potato peel biochar (PPc) can be considered a promising adsorbent for removing persistent dyes from water.
Potential design problems for ITER fusion device
Authors: Hassanein A. , Sizyuk V. 
Published: January 2021

AbstractThe international thermonuclear experimental reactor (ITER) is a worldwide project currently being built in France for the demonstration of the feasibility of thermonuclear technologies for future realization of successful commercial fusion energy. ITER is of the tokamak based design using strong magnetic fields to confine the very hot plasma needed to induce the fusion reaction. Tokamak devices are currently the front leading designs. Building a successful magnetic fusion device for energy production is of great challenge. A key obstacle to such design is the performance during abnormal events including plasma disruptions and so-called edge-localized modes (ELMs). In these events, a massive and sudden release of energy occurs quickly, due to loss of full or partial plasma confinement, leading to very high transient power loads on the reactor surface boundaries. A successful reactor design should tolerate several of these transient events without serious damages such as melting and vaporization of the structure. This paper highlights, through comprehensive state-of-the-art computer simulation of the entire ITER interior design during such transient events, e.g., ELMs occurring at normal operation and disruptions during abnormal operation, potential serious problems with current plasma facing components (PFCs) design. The HEIGHTS computer package is used in these simulations. The ITER reactor design was simulated in full and exact 3D geometry including all known relevant physical processes involved during these transient events. The current ITER divertor design may not work properly and may requires significant modifications or new innovative design to prevent serious damage and to ensure successful operation.
Suppression of IL-23-mediated psoriasis-like inflammation by regulatory B cells
Authors: Mizumaki Kie , Horii Motoki , Kano Miyu , Komuro Akito , Matsushita Takashi 
Published: January 2021

AbstractPsoriasis is an inflammatory cutaneous disease mediated by T-cell dependent immune responses; however, B cells are also considered to play an important role its development. Regulatory B cells (Bregs) regulate immune responses negatively through interleukin-10 (IL-10) production. This study aimed to investigate the role of Bregs in IL-23-mediated psoriasis-like inflammation in mice. Psoriasis-like inflammation was induced in B cell-specific phosphatase and tensin homolog (PTEN)-deficient mice, in which Bregs were significantly expanded, and in their controls, by intradermal injection of 20 μL phosphate-buffered saline (PBS) containing 0.5 μg rmIL-23 into one ear, every other day for 16 days. IL-23-mediated psoriasis-like inflammation was suppressed in B cell-specific PTEN-deficient mice along with decreased ear thickness and epidermal thickness on day 15. Moreover, adoptive transfer of B1 B cells suppressed IL-23-mediated psoriasis-like inflammation. rmIL-23-injected B cell-specific PTEN-deficient mice showed expanded regulatory T cells (Tregs) in the spleen and draining lymph nodes along with increased Bregs. Further, T helper (Th) 17 differentiation in the rmIL-23-injected ear was suppressed in B cell-specific PTEN-deficient mice. Overall, these results indicate that increased Bregs suppress IL-23-mediated psoriasis-like inflammation through Treg expansion and inhibition of Th17 differentiation. Thus, targeting Bregs may be a feasible treatment strategy for psoriasis.
Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
Authors: Okada Hiroshi , Tanaka Muhei , Yasuda Takashi , Okada Yuki , Norikae Hisahiro , Fujita Tetsuya , Nishi Takashi , Oyamada Hirokazu , Yamane Tetsuro , Fukui Michiaki 
Published: January 2021

AbstractCardiovascular disease (CVD) is still the major cause of mortality in patients with type 2 diabetes. Despite of recent therapies, mortality and resources spent on healthcare due to CVD is still important problem. Thus, appropriate markers are needed to predict poor outcomes. Therefore, we investigated the role of peripheral perfusion as an indicator for cardiovascular death in patients with type 2 diabetes and established CVD. This retrospective cohort study included 1080 patients with type 2 diabetes and history of CVD recruited from the outpatient clinic at Matsushita Memorial Hospital in Osaka, Japan. Peripheral perfusion is assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. The median age and PI values were 74 years (range: 67–79 years) and 2.6% (range: 1.1–4.3%), respectively. During follow-up duration, 60 patients died due to CVD. The adjusted Cox regression analysis demonstrated that the risk of developing cardiovascular death was higher in the first quartile (Hazard ratio, 6.23; 95% CI, 2.28 to 22.12) or second quartile (Hazard ratio, 3.04; 95% CI, 1.46 to 6.85) of PI than that in the highest quartile (fourth quartile) of PI. PI (per 1% decrease) was associated with the development of cardiovascular death (Hazard ratio, 1.39; 95% CI, 1.16 to 1.68). PI could be a novel indicator of cardiovascular death in patients with type 2 diabetes and established CVD.
Low-reflective wire-grid polariser sheet in the visible region fabricated by a nanoprinting process
Authors: Hokari Ryohei , Takakuwa Kyohei , Kato Hirohisa , Yamamoto Akitaka , Yamaguchi Yusuke , Kurihara Kazuma 
Published: January 2021

AbstractFor the construction of next-generation optical products and systems, the evolution of polariser sheets is a necessary requirement. To this end, a low-reflective wire-grid polariser (WGP) sheet for the visible light region is demonstrated, the nanowires of which consist of a sintered body of silver nanoparticle ink. The nanowires are formed by a nanoprinting process using a thermal nanoimprint method and ink filling. This process makes it easier to achieve multiple wafer-scale productions without using sophisticated equipment compared to conventional WGP nanofabrication techniques, which typically employ lithography and elaborate etching processes. The optical characteristics are controlled by the shape of the printed nanowires. A WGP sheet with a luminous degree of polarisation of 99.0%, a total luminous transmittance of 13.6%, and a luminous reflectance of 3.6% is produced. Its low reflectance is achieved through the uneven surface derived from the sintered body of the nanoparticle ink, and the shape of the bottom of the nanowire is derived from the tip shape of the mould structure. Furthermore, the printed WGP sheet has the durability required for the manufacturing of curved products, including sunglasses. The optical structures made of nanoparticle ink using this nanoprinting process have the potential to significantly contribute to the development of fine-structured optical elements with unprecedented functionality.
Prediction of 3D Cardiovascular hemodynamics before and after coronary artery bypass surgery via deep learning
Authors: Li Gaoyang , Wang Haoran , Zhang Mingzi , Tupin Simon , Qiao Aike , Liu Youjun , Ohta Makoto , Anzai Hitomi 
Published: January 2021

AbstractThe clinical treatment planning of coronary heart disease requires hemodynamic parameters to provide proper guidance. Computational fluid dynamics (CFD) is gradually used in the simulation of cardiovascular hemodynamics. However, for the patient-specific model, the complex operation and high computational cost of CFD hinder its clinical application. To deal with these problems, we develop cardiovascular hemodynamic point datasets and a dual sampling channel deep learning network, which can analyze and reproduce the relationship between the cardiovascular geometry and internal hemodynamics. The statistical analysis shows that the hemodynamic prediction results of deep learning are in agreement with the conventional CFD method, but the calculation time is reduced 600-fold. In terms of over 2 million nodes, prediction accuracy of around 90%, computational efficiency to predict cardiovascular hemodynamics within 1 second, and universality for evaluating complex arterial system, our deep learning method can meet the needs of most situations.
Direct measurements reveal instabilities and turbulence within large amplitude internal solitary waves beneath the ocean
Authors: Chang Ming-Huei , Cheng Yu-Hsin , Yang Yiing Jang , Jan Sen , Ramp Steven R. , Reeder D. Benjamin , Hsieh Wan-Ting , Ko Dong S. , Davis Kristen A. , Shao Huan-Jie , Tseng Ruo-Shan 
Published: January 2021

AbstractInternal solitary waves are ubiquitous in coastal regions and marginal seas of the world’s oceans. As the waves shoal shoreward, they lose the energy obtained from ocean tides through globally significant turbulent mixing and dissipation and consequently pump nutrient-rich water to nourish coastal ecosystem. Here we present fine-scale, direct measurements of shoaling internal solitary waves in the South China Sea, which allow for an examination of the physical processes triggering the intensive turbulent mixing in their interior. These are convective breaking in the wave core and the collapse of Kelvin–Helmholtz billows in the wave rear and lower periphery of the core, often occurring simultaneously. The former takes place when the particle velocity exceeds the wave’s propagating velocity. The latter is caused by the instability induced by the strong velocity shear overcoming the stratification. The instabilities generate turbulence levels four orders of magnitude larger than that in the open ocean.
Limits of reproducibility and hydrodynamic noise in atmospheric regional modelling
Authors: Geyer Beate , Ludwig Thomas , von Storch Hans 
Published: January 2021

AbstractReproducibility of research results is a fundamental quality criterion in science; thus, computer architecture effects on simulation results must be determined. Here, we investigate whether an ensemble of runs of a regional climate model with the same code on different computer platforms generates the same sequences of similar and dissimilar weather streams when noise is seeded using different initial states of the atmosphere. Both ensembles were produced using a regional climate model named COSMO-CLM5.0 model with ERA-Interim forcing. Divergent phase timing was dependent on the dynamic state of the atmosphere and was not affected by noise seeded by changing computers or initial model state variations. Bitwise reproducibility of numerical results is possible with such models only if everything is fixed (i.e., computer, compiler, chosen options, boundary values, and initial conditions) and the order of mathematical operations is unchanged between program runs; otherwise, at best, statistically identical simulation results can be expected.
A non‐invertible transformation based technique to protect a fingerprint template
Authors: Baghel Vivek Singh , Ali Syed Sadaf , Prakash Surya 
Published: January 2021

AbstractA fingerprint‐based authentication system provides security to the applications of numerous fields and usually stores minutiae information in the database as a template. It has been observed from the literature that the reconstruction of an original fingerprint is possible from minutiae points information; hence the security of the stored template becomes extremely crucial. Cancellable biometric techniques based on non‐invertible transformation protect the stored template. These techniques prevent the reconstruction of original fingerprint data from the compromised template and avoid unauthorized access to the system. In this paper, a technique based on the non‐invertible transformation to protect a fingerprint template is proposed. In the technique, minutiae locations in a fingerprint are transformed by using the minutiae's original locations and orientation information, and a user keyset. A principal component analysis based approach to align the probe and gallery templates of fingerprint images while matching is also proposed. The evaluation of the proposed technique is carried out on seven different fingerprint databases taken from FVC2000, FVC2002, and FVC2004 databases, and its performance is compared with other existing state‐of‐the‐art techniques in the literature. The comparative performance shows that the proposed technique is highly robust and performs exceptionally well compared to other existing techniques.
Metasurface virtual absorbers: unveiling operative conditions through equivalent lumped circuit model
Authors: Marini Angelica Viola , Ramaccia Davide , Toscano Alessandro , Bilotti Filiberto 
Published: January 2021

Virtual absorption concept has been recently introduced as a new phenomenon observed in electromagnetics and optics consisting of theoretically unlimited accumulation of energy within a finite volume of material without dissipation. The anomalous behaviour is achieved by engaging the complex zero scattering eigenmodes of the virtual absorbing system by illuminating it with a proper complex frequency ω = ω

r
+ jω

i
, whose value is strictly determined by the system characteristics. In this paper, we investigate on the position of the zero-pole scattering pairs in the complex frequency plane as a function of the input impedance of the metasurface-based lossless virtual absorber. We analytically derive the conditions under which a properly modulated monochromatic plane wave can be virtually absorbed by the system and stored within its volume. The analysis is developed by modelling the propagation of a normally impinging plane wave through its equivalent transmission line model terminated in an arbitrary reactive load, which in turn models the input impedance of the metasurface-based system under consideration. The study allows to determine a priori whether the metasurface-based system can support the virtual absorption or not by evaluating the time-constant from its equivalent circuit.