bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Cumulative Live Birth Rates Per Aspiration IVF/ICSI Cycle Between GnRH Antagonist Protocol and Progesterone-Primed Ovarian Stimulation Protocol for Infertility With Normal Ovarian Reserve: A Randomised Controlled Trial
Authors: Ye Hongjuan , Xue Xue , Shi Liya , Qian Ying , Wang Hui , Quan Xinxin , Tian Hui , Xue Songguo , Chen Qiuju , Sun Lihua 
Published: October 2021

Abstract
Background: Oral progestin has been used to prevent premature ovulation during follicle stimulation protocols performed in combination with a freeze-only strategy. However, no studies have determined how oral progestin clinically compares to gonadotropin-releasing hormone (GnRH) antagonists in women with normal ovulation. This study aimed to compare the efficacy and safety of controlled ovarian stimulation between progestin-primed ovarian stimulation (PPOS) protocol and GnRH antagonist (GnRH-ant) protocol.Methods: Young women with infertility and normal ovarian reserve who underwent in vitro fertilisation (IVF) treatments were screened and randomly allocated to the PPOS or GnRH-ant group. Women in the PPOS group underwent freeze-all and delayed embryo transfer, whilst fresh embryo transfer was preferred for those in the GnRH-ant group. The primary endpoint was the cumulative live birth rate (CLBR). Secondary endpoints included the incidence of premature luteinising hormone (LH) surge and the number of viable embryos.Results: CLBRs were similar in the PPOS and GnRH-ant group (55.75% vs. 52.87%, respectively, P > 0.05). No premature LH surge was observed during ovarian stimulation in the PPOS group, although six (3.45%) cases were observed in the GnRH-ant group. On the trigger day, LH level was lower in the PPOS group than in the GnRH-ant group (2.30 ± 1.78 mIU/ml vs. 3.66 ± 3.52 mIU/ml, P < 0.01). There were no differences in the number of retrieved oocytes, mature oocytes, or viable embryos between the two groups. Other clinical outcomes including implantation rates (37.27% vs. 36.77%), clinical pregnancy rates (55.75% vs. 55.89%), and miscarriage rates (12.28% vs. 13.76%) were comparable between the PPOS group and GnRH-ant group (P > 0.05). There was also no significant differences in newborn weights for singleton or twin births between the two groups (P > 0.05).Conclusion: Live birth outcomes are similar for PPOS and GnRH antagonist protocols in women with normal ovarian reserve. PPOS is likely to play a promising role in the freeze-only strategy given its simplicity and convenience for the patient. Trial registration: This trial was registered in the China Clinical Trial Registry on September 6, 2018 (number: ChiCTR1800018246).
External validation and comparison of the Glasgow-Blatchford bleeding score, the Rockall score and the AIMS65 score in upper gastro-intestinal hemorrhage: A cross-sectional observational study in Western Switzerland
Authors: Rivieri Sirio , Carron Pierre-Nicolas , Schoepfer Alain , Ageron Francois-Xavier 
Published: October 2021

Abstract
Background: Upper gastro-intestinal bleeding presents a high incidence in Emergency department. This study aims to externally validate and determine the performance of the Rockall score, the Glasgow-Blatchford bleeding, the modified Glasgow Blatchford score (mGBS) and the AIMS65 score in an Emergency department.Methods: We performed a retrospective cross-sectional observational study between January 1, 2015 and December 31, 2019. We performed Receiver-Operating Characteristic curve and area under the curve (AUROC) to compare discrimination for each scores. The primary outcome was need for intervention or death, including transfusion, endoscopic or surgery intervention. The secondary outcome was in-hospital death.Results: We enrolled 1,521 patients with UIGB. Mean age was 68 [52 – 81] years old, 62 % were men. Melena and/or hematemesis were the most common complain at ED (73%). Primary outcome was positive for 422 patients (27.7%), 76 patients (5%) were positive for our secondary outcome. The Glasgow-Blatchford score and the modified Glasgow-Blatchford score shown the highest area AUROC, respectively 0.774 (95% CI=0.750-0.798) and 0.782 (95% CI=0.759-0.805). AIMS-65 and Pre-endoscopic Rockall score shown lower discrimination, respectively, 0.684 (95% CI=0.657-0.711) and 0.647 (95% CI=0.618-0.675).Conclusion: Regarding our primary outcome, the modified Glasgow-Blatchford score and the Glasgow-Blatchford score presented a good performance. A GBS or mGBS of 0 is safe to rule-out patients with UIGB from ED. Performance of AIMS-65 score and Pre-endoscopic Rockall score were moderate.
Paper Mulberry Fruit Juice: a Novel Biomass Resource For Bioethanol Production
Authors: Ajayo Pleasure Chisom , Huang Mei , Zhao Li , Tian Dong , Jiang Qin , Deng Shihuai , Zeng Yongmei , Shen Fei 
Published: October 2021

Abstract
By way of broadening the use of diverse sustainable bioethanol feedstocks, the potentials of Paper mulberry fruit juice (PMFJ), as a non-food, sugar-based substrate, was for the first time evaluated for fuel ethanol production. Without any external nutrient supplementation, the suitability of PMFJ was proven, as maximum ethanol concentration (56.4 g/L), and yield (0.39 g/g), were achieved within half a day of the start of fermentation, corresponding to a very high ethanol productivity of 4.7 g/L/hr. Using Response Surface Methodology, established potentials were further maximized through statistical optimization of process conditions of temperature (20 – 40 ⁰C), yeast concentration (0.5 – 2 g/L), and pH (4 – 6). At the optimal temperature of 30 ⁰C, inoculum size of 0.55 g/L, and pH of 5, ethanol concentration, productivity, and yield obtained were 73.69 g/L, 4.61 g/L/hr, and 0.48 g/g, respectively. Under this ideal process conditions, bioethanol from PMFJ compares favorably with typical sugar-based energy crops, highlighting its resourcefulness as a high value biomass resource for fuel ethanol production.
Experimental Validation of a Potential Circulating microRNA Panel for Non-Invasive Pancreatic Cancer Diagnosis
Authors: Salehi Ali Seyed , Parsa Negar , Roshan-Farzad Farnaz , Behmanesh Ali , Fathi Mohadeseh , aghdaei Hamid Asaszadeh , Shams Roshanak 
Published: October 2021

Abstract
MicroRNA (miRNA) expression dysregulations in pancreatic ductal adenocarcinoma (PDAC) have been studied widely for their diagnostic and prognostic utility. By the use of Bioinformatics-based methods, in our previous study, we identified some potential miRNA panels for diagnosis of Pancreatic cancer patients from non-cancerous controls (the screening stage). In this report, we used 142 plasma samples from people with and without pancreatic cancer (PC) to conduct RT-qPCR differential expression analysis to assess the strength of the first previously proposed diagnostic panel (consisting of miR-125a-3p, miR-4530 and miR-92a-2-5p). For this aim the research was divided into two phases: testing, and external validation. A total of 92 PC plasma samples and normal controls (NCs) were evaluated in the testing stage to determine the ability of the considered miRNAs to discriminate cancer from non-cancer samples as a panel. Furthermore, in the external validation phase, a group of 25 PC serum samples vs. 25 NCs was employed to validate the diagnostic value of the panel. As the result, we identified significant up-regulation for all the three considered miRNAs in the serum of PC patients. After that, a three-miRNA panel in serum was developed. For the testing, validating and combined stages, the area under the receiver operating characteristic curves (AUC) for the panel were 0.850, 0.910 and 0.86 respectively, indicating that it had a higher diagnostic value than individual miRNAs. Therefore, we detected a promising three-miRNA panel in the plasma for non-invasive PC diagnosis (miR-125a-3p, miR-4530 and miR-92a-2-5p).
A Dosimetric Comparison of CT- and Photogrammetry- Generated 3D Printed HDR Brachytherapy Surface Applicators
Authors: Bridger Corey , Reich Paul , Santos Alexandre M Caraça , Douglass Michael J.J 
Published: October 2021

Abstract
In this study, we investigate whether an acceptable dosimetric plan can be obtained for a surface applicator designed using photogrammetry and compare the plan quality to a CT-derived applicator. The nose region of a RANDO anthropomorphic phantom was selected as the treatment site due to its high curvature. Photographs were captured using a Nikon D5600 DSLR camera and reconstructed using Agisoft Metashape while CT data was obtained using a Canon Aquillion scanner. Virtual surface applicators were designed in Blender and printed with ABS plastic. Treatment plans with a prescription dose of 3.85 Gy x 10 fractions with 100 % dose to PTV on the bridge of the nose at 2 mm depth were generated separately using AcurosBV in the Varian BrachyVision TPS. PTV D98%, D90% and V100%, and OAR D0.1cc, D2cc and V50% dose metrics and dwell times were evaluated, with the applicator fit assessed by air-gap volume measurements. Both types of surface applicators were printed with minimal defects and visually fitted well to the target area. The measured air-gap volume between the photogrammetry applicator and phantom surface was 44 % larger than the CT-designed applicator, with a mean air gap thickness of 3.24 and 2.88 mm, respectively. The largest difference in the dose metric observed for the PTV and OAR was the PTV V100% of -1.27 % and skin D0.1cc of -0.28 %. PTV D98% and D90% and OAR D2cc and V50% for the photogrammetry based plan were all within 0.5 % of the CT based plan. Total dwell times were also within 5 %. A 3D printed surface applicator for the nose was successfully constructed using photogrammetry techniques. Although it produced a larger air gap between the surface applicator and phantom surface, a clinically acceptable dose plan was created with similar PTV and OAR dose metrics to the CT-designed applicator. Additional future work is required to comprehensively evaluate its suitability in a clinically environment.
Determinant of Pneumonia Among Children Aged 2-59 Months in Public Health Facilities in Worabe Town, Southern Ethiopia: Facility-Based Case Control Study
Authors: Seramo Roza kumdin , Awol Shikur Mohammed , Wabe Yasin Awol , Ali Musa Mohammed 
Published: October 2021

Abstract
Introduction:

Childhood pneumonia remains a major health problem in developing countries, including Ethiopia with significant morbidity and mortality. The determinants of pneumonia in children under –five years of age children are numerous and vary widely vary across the regions of the world. Taking the significance of the problem and variability of risk factors, a study is needed to identify the potential determinants of pneumonia in children under-five children years of age.
Methods

A facility-based unmatched case-control study was conducted among 435 children (145 cases and 290 controls) aged 2-59 months at public health facilities in Worabe town from December 28, 2016 to January 30, 2017. Data were collected with a pretested interviewer-administered questionnaire, and entered into Epi info and transferred to SPSS version 22 for analysis. Univariate and multivariable logistic regression was employed with a 95% CI, and a p- value of < 0.05 was used as a determinant of pneumonia.
Results

Among the factors assessed in this study, stunting [AOR=3.6, 95% CI: 1.9-6.9], carrying the child on the back during cooking [AOR= 2.0, 95% CI: 1.2-3.2], absence of chimney in the cooking room [AOR= 2.2, 95% CI: 1.3-3.7], having a history of asthma [AOR= 5.0, 95% CI: 2-12], and a previous upper respiratory tract infection [AOR= 3.7, 95% CI:2.3-6.1] were found to be determinants of pneumonia.
Conclusions

Children with stunting, a previous history of asthma, acute upper respiratory tract infection and carrying the child on back during cooking were at higher risk of pneumonia. Therefore, all health institutions should promote early treatment and provision of health education about the health risk of child exposure to biomass fuel smoke and early health-seeking for childhood illnesses.
Hif1α-Dependent Hypoxia Signaling Contributes to the Survival of Deep-Layer Neurons and Cortex Formation in A Mouse Model
Authors: Sakai Daisuke , Sugawara Takeru , Kurokawa Tomonori , Murakami Yuki , Tomosugi Mitsuhiro , Masuta Hiroko , Sakata-Haga Hiromi , Hatta Toshihisa , Shoji Hiroki 
Published: October 2021

Abstract
Hypoxia-inducible factor 1 a (Hif1α) plays a crucial role in brain development. To study the function of Hif1α in early brain development, we generated neuroepithelial cell-specific Hif1α-knockout mice. Hif1α-knockout mice died soon after birth; these mice exhibited an abnormal head shape, indicating the presence of brain defects. Morphological analysis revealed that Hif1α ablation reduced the overall size of the brain, especially affecting the telencephalon. Neuronal apoptosis predominantly occurred in deep-layer neurons, consequently the alignment of cortical layers was severely disorganized in Hif1α knockout mice. Furthermore, we demonstrated that Vegf signaling contributes to the survival of deep-layer neurons as a downstream effector of Hif1α-dependent hypoxia signaling. Taken together, our findings demonstrate that Hif1α plays a critical role in the early stages of telencephalon development.
Brno University of Technology ECG Signal Database with Annotations of P Wave (BUT PDB)
Authors: Maršánová Lucie , Smíšek Radovan , Němcová Andrea , Smital Lukáš , Vítek Martin 
Published: October 2021

Abstract
Background: Brno University of Technology ECG Signal Database with Annotations of P Wave (BUT PDB) is an ECG signal database with marked peaks of P waves created by the cardiology team at the Department of Biomedical Engineering, Brno University of Technology. Results: The database consists of 50 2-minute 2-lead ECG signal records with various types of pathologies. The ECGs were selected from 3 existing databases of ECG signal - MIT-BIH Arrhythmia Database, MIT-BIH Supraventricular Arrhythmia Database and Long Term AF Database. The P waves positions were manually annotated by two ECG experts in all 50 records. Each record contains also dominant diagnosis (pathology) present in the record and annotated positions and types of QRS complexes (from the original database). Conclusion: The database is created for the development, evaluation and objective comparison of P wave detection algorithms.
Biosynthesis of silver nanoparticles from Pseudomonas fluorescens and their antifungal activity against Aspergillus niger and Fusarium udum
Authors: Sikka Aneesh , Sodimalla Triveni , NAGARAJU YALAVARTHI 
Published: October 2021

Abstract
In recent years, emerging plant diseases have posed a significant danger to global economies. Fungicide resistance and climate change are the two primary sources of pathogen outbreaks. The silver nanoparticles have been demonstrated to restrain pathogenic bacteria, fungi, and viruses with minimal risk of developing resistance and phytotoxicity. The synthesis of silver nanoparticles via chemical and physical methods raises concerns about environmental safety and production costs. The microbial bio-fabrication of silver nanoparticles is simple, cost-effective, and ready-to-use technology. In the current investigation, we used Pseudomonas fluorescens cell filtrates for the synthesis of silver nanoparticles. The silver nanoparticles were characterized using Dynamic Light Scattering (DLS), zeta potential (ζ), UV-Vis spectroscopy, SPR analysis, Transmission Electron Microscopy. Both silver nanoparticles and AgNO3 were tested for their ability to inhibit two phytopathogenic fungi, i.e., Fusarium udum and Aspergillus niger. Potent inhibition of mycelial growth was observed when silver nanoparticles were used at a concentration of 150 ppm. However, further research is needed to assess the toxicity of AgNPs before they are mass-produced and used in agricultural applications.
Biomechanical Evaluation of Prosthetic Feet Designed Using the Lower Leg Trajectory Error Framework
Authors: Prost Victor , Johnson W. Brett , Kent Jenny A. , Major Matthew J. , Winter Amos G. 
Published: October 2021

Abstract
The walking pattern and comfort of a person with lower limb amputation are determined by the prosthetic foot’s diverse set of mechanical characteristics. However, most design methodologies are iterative and focus on individual parameters, preventing a holistic design of prosthetic feet for a user’s body size and walking preferences. Here we refined and evaluated the lower leg trajectory error (LLTE) framework, a novel quantitative and predictive design methodology that optimizes the mechanical function of a user’s prosthesis to encourage gait dynamics that match their body size and desired walking pattern. Five people with unilateral below-knee amputation walked over-ground at self-selected speeds using an LLTE-optimized foot made of Nylon 6/6, their daily-use foot, and a standardized commercial energy storage and return (ESR) foot. Using the LLTE feet, target able-bodied kinematics and kinetics were replicated to within 5.2% and 13.9%, respectively, 13.5% closer than with the commercial ESR foot. Additionally, energy return and center of mass propulsion work were 46% and 34% greater compared to the other two prostheses, which could lead to reduced walking effort. Similarly, peak limb loading and flexion moment on the intact leg were reduced by an average of 13.1%, lowering risk of long-term injuries. LLTE-feet were preferred over the commercial ESR foot across all users and preferred over the daily-use feet by two participants. These results suggest that the LLTE framework could be used to design customized, high performance ESR prostheses using low-cost Nylon 6/6 material.
A Possible Correlation between Facet Orientation and Development of Degenerative Cervical Spinal Stenosis
Authors: Wang Yalei , Ning Ning , Liu Hao , Chen Jiali , Wang Beiyu , Abudouaini Haimiti , Xie Jingying 
Published: October 2021

Abstract
Background

Previous studies have demonstrated the relationship between sagittal facet orientation and cervical degenerative spondylolisthesis. However, the associations between facet orientation and cervical spinal stenosis (CSS) have rarely been studied.
Methods

One hundred and twenty patients with CSS (CSS group) and 120 healthy participants (control group) were consecutively enrolled. The cervical facet angles and anteroposterior diameter (A-P diameter) of spinal canal at each subaxial cervical levels were measured using axial magnetic resonance imaging. The intersection angle of the midsagittal line of the vertebra to the facet line represents the orientation of the facet joint.
Results

The facet angles on the right side at C2- C3 and C3-C4 in CSS group and at C2- C3 in control group had significantly higher values than those of the other sides. Besides, the facet angles and A-P diameter of spinal canal in CSS group were significantly smaller than those in control group at all levels (p < 0.05).
Conclusions

Our study demonstrated that patients with CSS have smaller axial cervical facet joint angles compared to the healthy individuals. Further studies are needed to elicit the specific underlying mechanism between sagittalization of the cervical facet joints and the pathology of CSS.
“A place to be safe, feel at home and get better”: Including the experiential knowledge of potential users in the design of the first wet service in Montreal, Canada
Authors: OCHOA ROSSIO MOTTA , Incio-Serra Natalia , Poliquin Hélène , MacDonald Sue-Ann , Huỳnhe Christophe , Côté Philippe-Benoit , Fallu Jean-Sébastien , Flores-Aranda Jorge 
Published: October 2021

Abstract
BackgroundThe harmful use of alcohol is one of the leading health risk factors for people’s health worldwide, but some populations, like people who experience homelessness, are more vulnerable to its detrimental effects. In the past decades, harm reduction interventions that target these complex issues has been developed. For example, wet services include a wide range of arrangements (wet shelters, drop-in centers, transitory housing, etc.) that allow indoor alcohol use and Managed Alcohol Programs provide regulated doses of alcohol in addition to accommodation and services. Although the positive impacts of these interventions have been reported, little is known about how to integrate the knowledge of people experiencing homelessness and alcohol dependence into the design of such programs. The aim of this study is to present the findings of such an attempt in a first wet service in Montreal, Canada. MethodsCommunity based participatory research approach and qualitative methods–including semi-structured interviews and focus groups–were used to collect the knowledge of potential users (n = 34) of the wet service. The data collected was thematically analyzed. ResultsParticipants reported experiencing harsh living conditions, poverty, stigmatization and police harassment, which increased their alcohol use. The intersection between participants’ alcohol dependence and homelessness with the high barriers to access public services translated into their exclusion from several of such services. Participants envisioned Montreal’s wet service as a safe space to drink, a place that would provide multiple services, a home, and a site of recovery. ConclusionsIntegrating the knowledge of potential users into the design of harm reduction interventions is essential to develop better and more adapted services to meet complex needs. We propose that it could fosters users’ engagement and contribute to their sense of empower, which is crucial for a group that is typically discriminated against and suffers from marginalization.
Recovery of Hydrothermal Wustite-Magnetite Spherules from the Central Indian Ridge, Indian Ocean.
Authors: Agarwal Deepak K. , Palayil John Kurian 
Published: October 2021

Abstract
Not many studies have reported the hydrothermal-related origin of the magnetite-bearing spherules, and hardly any literature discusses the hydrothermal-related origin of wustite-magnetite-bearing spherules. A sediment sample with high abundance (19 spherules in ~85 g) of spherules is recovered from Central Indian Ridge (CIR) segment S2 (70°54′E, 25°14′S to 70°50′E, 24°41′S), ~85 km north of Rodrigues triple junction (RTJ). On the external surface of the spherules, magnetite appears as crystals, whereas wustite mostly appears as a homogenous glass phase. These spherules are composed of wustite and magnetite hosting Mn, unlike micrometeorites which essentially hosts Ni. Mn is more heterogeneously distributed with a relatively higher concentration in the wustite phase than the magnetite, suggesting hydrothermal origin. Furthermore, the presence of sulfide nano-particles in the wustite phase and a minor quantity of Pb and S in the ferrihydrite matrix points to the fact that CIR spherules are of hydrothermal origin. We propose that the CIR spherules originated by the interaction of the reduced hydrothermal fluids with the ultramafic/basaltic rocks or silica-undersaturated magmatic melts. The finding of Mn hosting wustite-magnetite assemblage suggests an active hydrothermal system in the near vicinity and can be considered as an additional proxy for locating hydrothermal vents.