bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Congenital Cataract Surgery on the Ocular Surface in a Six-Month Follow-Up Prospective Clinical Study
Authors: Lin Xiaolei , Li Hongzhe , Zhou Xiyue , Liu Xin , Fan Fan , Yang Tianke , Luo Yi 
Published: October 2021

Abstract
Background: The purpose of this study was to identify changes in tear film function and meibomian gland function in children after congenital cataract surgery.Methods: This study enrolled 21 eyes of 16 congenital cataract patients (mean age: 8.05±1.43 years) who underwent cataract surgery and 16 eyes of 16 normal volunteers (mean age: 8.31±2.18 years). Clinical assessments were conducted preoperatively and at 1 week, 1 month, 3 months and 6 months postoperatively. Symptom questionnaires, non-invasive tear ﬁlm break-up time, tear meniscus height, corneal fluorescein staining, lid margin abnormality, meibomian gland expressibility, and meibography were assessed.Results: The ocular symptom score was significantly higher in congenital cataract patients compared to normal controls during the 5 visits (P=0.009). And the average non-invasive tear ﬁlm break-up time was significantly lower in congenital cataract patients compared to normal controls (P=0.017). The first non-invasive tear ﬁlm break-up time and average non-invasive tear ﬁlm break-up time was lowest at 1 month postoperatively compared to baseline levels (P = 0.008 and P = 0.012, respectively). The lid margin score of the upper eyelid was significantly higher in congenital cataract patients compared to normal controls at 1 week postoperatively (P=0.027). The meibum expressibility score decreased significantly during the 5 visits (P=0.024). No significant difference was observed in meibomian gland tortuosity, meibomian gland width, meibomian gland area and meibomian gland length between the congenital group and normal controls preoperatively and at 6 months postoperatively (P>0.05).Conclusion:Tear film stability and meibomian gland function are worsened transiently after congenital cataract surgery without accompanying meibomian gland morphological changes.
Using Letrozole Cotreatment With Progestin-Primed Ovarian Stimulation In Women With Polycystic Ovary Syndrome Treated For IVF
Authors: Liu Yali , Lin Jiaying , Chen Li , Mao Xiaoyan , Wang Li , Chen Qiuju , Yu Sha , Kuang Yanping 
Published: October 2021

Abstract
Background: Women with polycystic ovary syndrome (PCOS) often experience poor oocyte quality and a high risk of ovarian hyperstimulation syndrome (OHSS) when treated with controlled ovarian stimulation (COS) in vitro fertilization (IVF). Progestin-primed ovarian stimulation (PPOS) shows good potential to compete with conventional protocols in women with PCOS. However, it always accompanied by increased pituitary suppression and gonadotropin consumption. Letrozole (LE) has the ability to increase luteinizing hormone (LH) levels and appears to have the potential to alleviate pituitary inhibition during COS in women with PCOS. A retrospective cohort trial was performed to evaluate the efficacy of PPOS with or without letrozole in infertile women with PCOS.Methods: This retrospective cohort study included 448 women with PCOS who underwent COS with human menopausal gonadotropin (hMG) and medroxyprogesterone acetate (MPA) (n=224) or hMG and MPA cotreatment with LE (n=224) from January 2018 to March 2021. Baseline characteristics of the two groups were balanced with propensity score matching using the nearest neighbour random matching algorithm at a ratio of 1:1. The primary outcome measure was the implantation rate. The secondary outcomes were the endocrinological profiles, gonadotropin dose and duration, number of oocytes retrieved and viable embryos, clinical pregnancy rate, miscarriage rate and ectopic pregnancy rates.Result(s): The implantation rate was significantly higher in the study group than that in the control group (42.22% vs. 34.69%, P < 0.05). Compared with the control group，the study group had a higher LH concentration on the trigger day (3.85±3.6 mIU/ml vs. 2.44±1.71 mIU/ml, P < 0.01), but there was no case of premature LH surge or OHSS in both groups. The consumption of gonadotropin, the number of oocytes retrieved and viable embryos were similar between the two groups. Additionally, no difference was found in the clinical pregnancy rate, miscarriage rate or ectopic pregnancy rate.Conclusion(s): This study shows that LE administration in the PPOS protocol was feasible to improve the implantation rate and alleviate profound pituitary suppression from progestin administration without interfering with its premature LH surge blockade effect but with a non-significant reduction in gonadotropin consumption in women with PCOS undergoing IVF treatment.
Switchable Structure Promoted Leaching Free Atomically Dispersed Pt Catalyst for Low Carbon Biomass Polyol Oxidation
Authors: Yan Hao , Zhao Mingyue , Zhou Xin , Zhao Siming , Li Shangfeng , Zha Minghao , Meng Fanyu , Feng Xiang , Chen Xiaobo , Liu Yibin , Chen De , Yan Ning , Yang Chaohe 
Published: October 2021

Abstract
Achieving efficient catalytic conversion over heterogeneous catalyst with excellent resistance against leaching is still a grand challenge for sustainable chemical synthesis in aqueous solution. Herein, we devised a leaching free atomically dispersed Pt1/hydroxyapatite (HAP) catalyst with unique switchable structure via a simple and green in-situ anchoring strategy. Gratifyingly, this robust Pt1/HAP catalyst exhibits remarkable catalytic selectivity and catalyst stability for the selective oxidation of C2-C4 bio-polyols (e.g., ethylene glycol, propanediol, glycerol and butanediol) to corresponding primary hydroxy acids. X-ray absorption spectroscopy, in-situ Fourier Transform infrared spectroscopy, density functional theory calculation and kinetics study elucidated that the switchable Pt-(O-P) linkages with strong electronic-withdrawing function of PO43− (Pt1-OPO43− active site) not only realize the activation of C-H bond, but also destabilize the transition state from adsorbed hydroxy acids toward the C-C cleavage, resulting in the sharply increased selectivity of hydroxy acids. Moreover, the strong PO43−-coordination effect, originating from the enhanced interaction between positively charged Pt1 and negatively charged OPO43−, provides electrostatic stabilization for the atomically dispersed Pt, ensuring the highly efficient catalysis of Pt1/HAP for over 160 hours without metal leaching. This finding opens up new opportunities for efficient upgrading of bio-polyols over atomically dispersed catalysts.
The Effect of Donor Transportation on the Function of Donor’s Organs
Authors: Liu Jianrong , Wang Zhuchun , An Yuling , Wei Xuxia , Yi Xiaomeng , Xu Qian , Chen Weijian , Tang Yue’e , Yi Huimin , Xiong Tianwei 
Published: October 2021

Abstract
Background: The impact of donor transportation on the outcome of deceased organ donation remains largely unknown. This study aimed to investigate the effect of donor transportation on the function of the donor’s organs. Methods: From 2016 to 2018, 139 donors of successful deceased organ donation from the local (primary) hospitals transferred to our hospital were included for analysis. Blood samples were drawn immediately after the donor admitted to our hospital (pre-transport data) and before donation (post-transport data) to assess the donor’s organ functions by determining the levels of blood biochemical indexes. Results: The donor with a transport distance >200 km had higher post-transportation AST and a bigger change of TB level as compared with those with a transport distance < 200 km. Pearson’s correlation analysis showed a positive correlation between transport distance and post-transport AST. The donors with cardiac arrest history had significantly higher pre-transport AST, pre-transport ALT, post-transport ALT, post-transport BUN, and the change level of BUN after transport as compared with those without cardiac arrest history. The donors with a history of cranial decompression surgery had significantly lower pre-transport AST, pre-transport ALT, and post-transport Cr as compared with those without a history of cranial decompression surgery. Conclusion: These results suggested that long-distance donor transportation may result in organ function deterioration, especially for donors with a cardiac arrest history. Donors with a history of intracranial decompression surgery can alleviate this problem.
PD-1 Inhibitor Plus Chemotherapy Versus Chemotherapy for First-Line Treatment in Advanced Esophageal Cancer: A Systematic Review and Meta-Analysis.
Authors: Lu Yao , Xu Mengli , Guan Lulu , Yang Yalan , Chen Yu , Yang Yuanyuan , Wang Feng 
Published: October 2021

Abstract
Background: Immunotherapy combined with chemotherapy has recently changed the first-line treatment of several cancers. We perform a systematic meta-analysis to assess the efficacy and safety of PD-1 inhibitor plus chemotherapy for first-line treatment in advanced esophageal cancer.Methods: Data were collected from eligible studies searched from PubMed, Web of Science, Cochrane Library, Embase, American society of clinical oncology (ASCO) and the European Society for Medical Oncology (ESMO). Pooled hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS), pooled odds ratio (OR) for objective response rate (ORR) and treatment-related adverse effects (TrAEs) were estimated to assess the efficacy and safety of PD-1 inhibitor plus chemotherapy versus chemotherapy. We performed several subgroup analyses to explore the variables on immunotherapy efﬁcacy for esophageal cancer. The ﬁve-point Jadad scoring system and the bias risk assessment were used to evaluate the quality of studies, and sensitivity analyses were carried out to evaluate the robustness of the combined outcomes. Results: Seven records involving 3754 participants were selected in our study. Compared to chemotherapy group, the OS (HR=0.72; 95% CI: 0.66-0.78, P<0.01), PFS (HR=0.62; 95% CI: 0.57-0.68, P<0.01) and ORR (OR=2.07; 95% CI: 1.76-2.43, P<0.01) were significantly longer in PD-1 inhibitor plus chemotherapy group. The overall survival benefit was observed in patients regardless of histology or PD-L1 combined positive score (CPS). OS and PFS were generally consistent across subgroups by clinical features. In safety analyses, PD-1 inhibitor plus chemotherapy had significantly higher incidence of TrAEs (OR=1.85; 95% CI: 1.21-2.84, P<0.01), but there was no statistical difference in grade 3 or higher TrAEs (OR=1.24; 95% CI: 1.00-1.55, P=0.05).Conclusion: Compared with chemotherapy, PD-1 inhibitor plus chemotherapy has an improvement of anti-tumor activity and controllable TrAEs for first-line treatment of advanced esophageal cancer.
Research on the Application of Virtual Reality Technology in the Scenery Park Landscape Design
Authors: tian Xiao 
Published: October 2021

Abstract
Virtual reality technology is of great significance in the scenery park landscape design. In order to further improve the related theories and links of this technology, this study is based on a clear concept of reading related information and the author uses the modeling software and through the example analysis to verify that the virtual reality technology has certain feasibility in the scenery park landscape design of our country. By using the method of fuzzy comprehensive evaluation, the author determines the main advantages of virtual reality technology in the scenery park landscape design. The purpose of this study is to provide data and theoretical reference for the improvement of the related theories and techniques of the scenery park landscape design in China.
Academic Half-Day Education Experience in Post-graduate Medical Training: A Scoping Review of Characteristics and Learner Outcomes
Authors: Choe Myong Sun , Huffman Lynne C. , Feldman Heidi M. , Hubner Lauren M. 
Published: October 2021

Abstract
Background

The academic half-day (AHD) has grown in popularity for medical education because it intends to provide learners with uninterrupted, immersive learning time that may promote participant attendance, engagement, and knowledge. Little is known about the extent of use, forms, or effectiveness of AHD in post-graduate medical education. This scoping review summarizes existing literature and describes the learning outcomes, according to the Kirkpatrick model of learning evaluation, of AHD experiences on post-graduate medical trainees.
Methods

Authors used Arksey and O’Malley’s methodological framework, searching electronic scientific literature databases from the years of 1977-2019 with relevant key terms and identifying 735 papers. Two independent raters completed title/abstract screening and then extracted pertinent data from papers meeting specified criteria.
Results

Authors identified 38 relevant papers published in English, originating from programs in US (n=19) and Canada (n=19), spanning 4 disciplines: Medicine (n=17, 45%), Pediatrics (n=10, 26%), Critical Care/Surgery (n=9, 24%), Radiology (n=2, 5%). A majority (n=33, 87%) described specific educational experiences; most focused on residents only (n=27). The educational experiences included various teaching strategies; few were didactics only (n=4) and most were multi-modal including simulation, case-based learning, problem-based learning, and/or self-directed online study. AHD size ranged from 5-364 participants (median 39). AHD length was 1.5-6 hours (median 3). Required resources were inconsistently described. When evaluations of the specific educational experience were reported (n=35 studies), the majority of studies used weak research designs (e.g., one group, pre/post-test, n=19); few studies used strong research designs (e.g., randomized controlled trial, n=2). Positive effects of AHD ranged across Kirkpatrick levels 1-3 learner outcomes.
Conclusions

The composition and content of AHD in post-graduate medical education vary. Few studies of AHD use stringent research designs, and none include learner outcome measures at the highest Kirkpatrick level (i.e., level 4 results/patient outcomes). A consensus definition and further high-quality research on AHD in post-graduate medical education is needed.
VEIWER: a Digital tool for visualising data in mental health records
Authors: Codling David 
Published: October 2021

Abstract
Background Electronic Audit and Feedback (eA&F) interventions aim to improve patient care by presenting clinicians with summarised information of clinical performance over time. We created an eA&F intervention to assist clinicians in the management of psychosis in the community. Methods The eA&F intervention was created collaborative between informaticians, computer scientists and clinicians and summarises population-level data on service useage, medications, psychological interventions and physical health on an interactive platform. We evaluated its usability usingt he systems usability scale (SUS), outcome data on physical health monitoring (Body Mass Index and Blood Pressure) using difference-in-difference analysis and interviewed clinicians, interpreting the data using thematic analysis. Results The system showed good usability (72 on SUS), although did not lead to improved recording of physical health or improved patient outcomes during the course of the study. Thematic analysis of interview data showed high numbers of statements around systemic barriers, and significant unrealised potential gains. Conclusions Our study represents a first attempt to create an eA&F intervention for use in mental healthcare. Patient outcomes were not improved in the limited scope of the study, however clinicians identified a number of unrealised gains. They also highlighted the need for protected time for reviewing data, training for clinicians and ensuring that there are empowered individuals within the team responsible for reviewing and responding to the data.
A Retrospective Analysis of the Significance of Serum Bilirubin Levels and Glycemic Measurements in Type 2 Diabetes Management in a Cohort of Patients in a Tertiary Care Hospital
Authors: Kariyawasan Chitranga Chysanthi , Kariyawasan Chitranga Chysanthi , Balasuriya Balasuriya Lekamlage Thushara , Ranatunga Sondapperuma Arachchige Charith Dakshitha , Dissanayake Dissanayake Mudiyanselage Champika , Herath Singappuli Ralalage Gemunu Priyantha 
Published: October 2021

Abstract
BackgroundIn type 2 Diabetes Mellitus (T2DM) chronic hyperglycemia leads to multi-organ damage. It is a chronic low-grade inflammation resulting in reduced antioxidants leading to many complications. Hyperglycemia causes glycation of serum proteins forming advanced glycation end products (AGEs). HBA1c is an AGE of haemoglobin. Bilirubin considered a waste product of the heme catabolic pathway, has proven to be a natural antioxidant associated with a lower prevalence of oxidative stress-mediated diseases. Bilirubin prevents glycation of proteins providing benefit in T2DM. General objective - To evaluate the association of serum bilirubin levels with HBA1c, FBS, PPBS in diabetes patients. Specific objectives - 1) To compare the serum bilirubin levels in diabetes patients with good and poor control. 2) To evaluate the association of HbA1c with FBS, PPBS and age in controlled and uncontrolled diabetes mellitusMethodology -A retrospective analytical study done at the department of Haematology of the Sri Jayewardenepura General Hospital.Sample selection and sample size -A random sampling technique used. Data obtained through laboratory information system of 201 adult patients diagnosed with T2DM. The study population grouped as poorly and well controlled using HbA1c value over and below 7% respectively. Normal ranges for serum bilirubin, FBS and PPBS was (0.3-1.2) mg/dl, (75- 110) mg/dl and (80-140) mg/dl respectively. Data were entered and analyzed using statistical package for social sciences (SPSS) version 20. Descriptive statistics used to calculate the median, mean and the standard deviation of age, serum bilirubin, HBA1c, FBS, and PPBS. Correlations between variables were done using Pearson’s Correlation method. The p value <0.05 was considered as statistically significant. Comparison of two diabetic groups were done using independent sample t test.Results. A negative correlation between total bilirubin and HbA1c (r = -0.234, p value = 0.001) with a low linear relationship (R Sq of 0.055, figure 02) observed. No statistical significance between total bilirubin level with FBS, PPBS and age (p value >0.05) but the mean values of these in the two groups were statistically significant (p value < 0.05). A statistically positive co-relation observed between HbA1c with FBS and PPBS, not with age. Conclusion. The significant negative correlation between total bilirubin and HbA1c, infers that a lower blood glucose level will result in reducing the oxidant stress mediated damage by the antioxidant and anti- inflammatory action of the increased oxygen free radicals produced by a high bilirubin.
Knowledge discovery and dengue forecasting applied in a four-year dataset collected at Natal/RN – Brazil
Authors: Sanchez-Gendriz Ignacio , Fountuora Gustavo , de Andrade Ion , Neto Adrião Duarte Doria , Tavares Alessandre de Medeiros , Barros Daniele , de Morais Antonio Higor Freire , Galvão-Lima Leonardo J. , Valentim Ricardo Alexsandro de Medeiros 
Published: October 2021

Abstract
Dengue is recognized as a health problem, it causes significant impacts on health worldwide, affecting millions of people each year. A useful method of dengue vector surveillance is to count Aedes aegypti eggs deposited in spatially distributed ovitraps. The present work uses a database collected in 397 ovitraps distributed in the municipality of Natal/RN – Brazil. The number of eggs in each ovitrap was counted weekly, for four years (2016 - 2019) and was analyzed jointly with the dengue incidence in the same period. Our results confirms that dengue incidence seems to be related to socioeconomic status on Natal’s municipality. Using a deep learning model, we predict the incidence of new dengue cases based on data obtained from the previous week of dengue or in the number of eggs present in the ovitraps. The analysis shows that ovitrap data allows earlier detection (4-6 weeks) than dengue cases itself (1 week). The results confirm that quantifying Aedes aegypti eggs can be valuable for planning health actions.
Colorimetric Immunological Paper-based Assay for Exosome Detection
Authors: Kasetsirikul Surasak , Shiddiky Muhammad J.A. , Nguyen Nam-Trung 
Published: October 2021

Abstract
This paper reports the development of colorimetric immunological paper-based assay for exosome detection. The paper-based device was fabricated with lamination technique for easy handling and create hydrophilic/hydrophobic region for analytical paper-based devices. Exosome-specific antibody was coated onto the paper-based devices as a biosensing platform to detect exosome sample from the cell culture media. This assay employed a colorimetric reaction which is followed by reaction between horseradish peroxidase (HRP) and 3,3’,5,5’-tetramethylbenzidine substrate (TMB). The colorimetric readout was qualitatively evaluated by naked eyes and was quantitatively assessed by image processing software. The result indicated that this assay faces many challenges. First, the exosome concentration may be inadequate to reach detectable range. Second, high background signal due to non-specific binding on the platform results in lack of sensitivity for exosome detection. Therefore, modification on the paper should promote protein binding for specific target and prevent non-specific binding to reduce the high background signal.
Conduction and Resistive Switching Memory in Al/MoS2+PVP/Ag Devices Fabricated using Drop cast Method
Authors: Dlamini Zolile Wiseman , Vallabhapurapu Sreedevi , Mahule Tebogo Sfiso , Wu Shuying , Vallabhapur Vijaya Srinivasu 
Published: October 2021

Abstract
Resistive switching in MoS2 embedded PVP composite-based ReRAM with Al and Ag electrodes is reported. A cost-free drop cast method was used to deposit active layers consisting of 30 wt%, 40 wt%, and 70 wt% of MoS2 in PVP. Each system exhibited unique electroforming and switching mode. Asymmetrical bipolar resistive switching occurring only in the positive voltage bias, a typical bipolar resistive switching and a typical ‘O-type’ resistive switching were observed for the 30 wt%, 40 wt%, and 70 wt% systems, respectively. Furthermore, injection of charge carriers at the electrode/active layer interface and electrochemical metalization mechanisms drove the formation of a nanoscale conductive filament in the device A and B. On the other hand, we attributed the conduction mechanism of device C to hopping conduction. Our results demonstrate the behaviour of MoS2 embedded PVP composite-based ReRAM has a strong dependence on the amount of MoS2 and that both the switching and conduction mechanism can be exploited by controlling the amount of MoS2 in the composite.