bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early response to trazodone once-a-day in major depressive disorder: review of the clinical data and putative mechanism for faster onset of action
Authors: Albert Umberto , Lamba Pallavi , Stahl Stephen M. 
Published: March 2021

AbstractBackgroundMost antidepressants have a delayed onset of action and must be administered for several weeks to generate therapeutic effects. Trazodone is a serotonin antagonist and reuptake inhibitor approved for the treatment of major depressive disorder. The once-a-day (OAD) formulation of trazodone has an improved tolerability profile compared to its conventional formulations. In this study, we systematically reviewed the evidence available for the antidepressant efficacy and early improvement in depressive symptoms with trazodone OAD treatment.MethodWe conducted a PubMed database search for randomized controlled trials published from 2005 to 2020.ResultsTwo studies, a placebo-controlled and an active-comparator (venlafaxine extended-release or XR) study were found. Both the studies demonstrated that trazodone exhibits antidepressant activity at a starting dose of 150 mg/day and results in statistically significant greater reduction in Hamilton Depression Rating Scale (HAM-D17) scores within 1 week of starting treatment compared to placebo or venlafaxine XR (P < .05). Trazodone also resulted in significant early improvement in the HAM-D17 sleep disturbance factor compared to placebo or venlafaxine XR at day 7 (P < .05). This clinical effect is supported by in vitro proprietary data for the affinity of trazodone for different target receptors. Activity at these receptors may underlie trazodone’s fast antidepressant action.ConclusionsTrazodone, if properly dosed, can be an effective antidepressant with early onset of action and good tolerability. Future studies designed to specifically evaluate onset and timing of improvement of depressive symptoms remain necessary to confirm and extend these results.
The updated ICRC Commentary on the Third Geneva Convention: A new tool to protect prisoners of war in the twenty-first century
Authors: Arman Jemma , Henckaerts Jean-Marie , Hiemstra Heleen , Krotiuk Kvitoslava 
Published: March 2021

AbstractSince their publication in the 1950s and 1980s respectively, the Commentaries on the Geneva Conventions of 1949 and their Additional Protocols of 1977 have become a major reference for the application and interpretation of those treaties. The International Committee of the Red Cross, together with a team of renowned experts, is currently updating these Commentaries in order to document developments and provide up-to-date interpretations of the treaty texts. This article highlights key points of interest covered in the updated Commentary on the Third Geneva Convention. It explains the fundamentals of the Convention: the historical background, the personal scope of application of the Convention and the fundamental protections that apply to all prisoners of war (PoWs). It then looks at the timing under which certain obligations are triggered, those prior to holding PoWs, those triggered by the taking of PoWs and during their captivity, and those at the end of a PoW's captivity. Finally, the article summarizes key substantive protections provided in the Third Convention.
Humanitarian aid in the age of COVID-19: A review of big data crisis analytics and the General Data Protection Regulation
Authors: Gazi Theodora , Gazis Alexandros 
Published: March 2021

AbstractThe COVID-19 pandemic has served as a wake-up call for humanitarian aid actors to reconsider data collection methods, as old ways of doing business become increasingly obsolete. Although access to information on the affected population is critical now more than ever to support the pandemic response, the limitation of aid workers’ presence in the field imposes hard constraints on relief projects. In this article, we consider how aid actors can use “big data” as a crisis response tool to support humanitarian projects, in cases when the General Data Protection Regulation is applicable. We also provide a framework for examining open-source platforms, and discuss the advantages and privacy challenges of big data.
EEG Cortical Activities and Networks Altered by Watching 2D/3D Virtual Reality Videos
Authors: Xu Xiaoying , Sui Li 
Published: March 2021

Abstract. Virtual reality (VR), which can represent real-life events and situations, is being increasingly applied to many fields, such as education, entertainment, and medical rehabilitation. Correspondingly, the neural information processing of VR has attracted attention. However, the underlying neural mechanisms of VR environments have not yet been fully revealed. The purpose of this study was to examine the possible differences in brain activities and networks between the less immersive 2D and the fully immersive 3D VR environments. 3D VR videos and the same 2D scenes were presented to the participants and the scalp electroencephalogram (EEG) was recorded, respectively. Power spectral density (PSD) and the functional connectivity of these EEG signals were analyzed. The results showed that 3D VR videos significantly enhanced the PSD of θ rhythm (4–7 Hz) in the frontal lobe; decreased the PSD of α rhythm (8–13 Hz) in the parietal and the occipital lobes; increased the PSD of β rhythm (14–30 Hz) in the frontal, the parietal, the temporal, and the occipital lobes, relative to 2D VR watching. Furthermore, 3D versus 2D VR-induced alterations in the patterns of brain networks were similar to the patterns of PSD. Specifically, for the θ rhythm, 3D VR significantly enhanced the frontal and the temporal brain functional connectivity; for the α rhythm, 3D VR increased the parietal and the occipital networks; for the β rhythm, 3D VR remarkably increased the frontal, the occipital, the frontal-temporal and the frontal-occipital brain functional connectivity, relative to 2D VR. These significant differences between 3D and 2D VR video-watching suggest that the neural information processing of cortical activities and networks is correlated to the degree of immersion. The present results, collected with previous researches, implicate that some visual-related information processes, such as visual attention, visual perception, and visual immersion are more robust in 3D VR environments.
Imaging VGOS Observations and Investigating Source Structure Effects
Authors: Xu Ming H. , Savolainen Tuomas , Zubko Nataliya , Poutanen Markku , Lunz Susanne , Schuh Harald , Wang Guang L. 
Published: March 2021

AbstractThe next‐generation, broadband geodetic very long baseline interferometry system, named VGOS, is being developed globally with an aim to achieve 1 mm accuracy for station positions. Currently, the systematic errors in VGOS broadband delays are still about 20 ps. In this study, we demonstrate that it is feasible to make images directly from VGOS observations without the need of complicated calibrations and determine the source structure effects in VGOS broadband delays through the process of model fitting to the structure phases from our imaging results. Source structure effects are investigated in detail, and it is shown that the systematic errors in VGOS observations are well explained by these effects. For instance, the root‐mean‐square (RMS) closure delays of the observations of sources 0016 + 731 and 1030 + 415 are 24.9 and 50.2 ps in session VO0034, respectively; after correcting source structure effects based on the images, the RMS values of the residual closure delays are 5.5 and 10.1 ps. The jumps in delay observables with magnitudes of several hundreds of picoseconds are found to be caused by 2π phase shifts among the four bands due to strong source structure effects. The impact of the alignment of the images at the four frequency bands in VGOS is discussed. Our study provides a methodology for deriving images of radio sources at the four bands of VGOS observations and discusses the alignment of the images at the four bands, which is fundamental to mitigating these systematic effects.
Mechanical Compaction of Crustal Analogs Made of Sintered Glass Beads: The Influence of Porosity and Grain Size
Authors: Carbillet Lucille , Heap Michael J. , Baud Patrick , Wadsworth Fabian B. , Reuschlé Thierry 
Published: March 2021

AbstractThe fundamentals of our understanding of the mechanical compaction of porous rocks stem from experimental studies. Yet, many of these studies use natural materials for which microstructural parameters are intrinsically coupled, hampering the diagnosis of relationships between microstructure and bulk sample behavior. To probe the influence of porosity and grain size on the mechanical compaction of granular rocks, we performed experiments on synthetic samples prepared by sintering monodisperse populations of glass beads, which allowed us to independently control porosity and grain diameter. We conducted hydrostatic and triaxial compression tests on synthetic samples with grain diameters and porosities in the ranges 0.2–1.15 mm and 0.18–0.38 mm, respectively. During hydrostatic compaction, sample porosity decreased suddenly and substantially at the onset of inelastic compaction due to contemporaneous and extensive grain crushing, a consequence of the monodisperse grain size. During triaxial tests at high confining pressure, our synthetic samples failed by shear‐enhanced compaction and showed evidence for the development of compaction bands. Critical stresses at the onset of inelastic compaction map out linear‐shaped yield caps for the porosity‐grain diameter combinations for which the critical stress for inelastic hydrostatic compaction is known. Our yield caps reinforce the first‐order importance of porosity on the compactive yield strength and show, all else being equal, that grain size also exerts a first‐order control and should therefore be routinely measured. Our study further reveals the suitability of sintered glass beads as analogs for crustal rocks, which facilitate the study of the deconvolved influence of microstructural parameters on their mechanical behavior.
Groundwater Regulates Interannual Variations in Evapotranspiration in a Riparian Semiarid Ecosystem
Authors: Missik Justine E. C. , Liu Heping , Gao Zhongming , Huang Maoyi , Chen Xingyuan , Arntzen Evan , Mcfarland Douglas P. , Verbeke Brittany 
Published: March 2021

AbstractDrylands are an important component of Earth's carbon, water, and energy budgets. Changes in hydroclimatic conditions can significantly alter land surface fluxes in these ecosystems. In regions with groundwater‐river water exchange, land surface fluxes are strongly modulated by groundwater table fluctuations in response to river stage variations; however, interactions between fluxes and groundwater remain poorly understood in drylands. Here, we use eddy covariance data collected in paired upland and riparian semiarid ecosystems (AmeriFlux sites US‐Hn1 and US‐Hn2) during 4 years with contrasting river flow conditions to examine interactions among river stage, water table dynamics, meteorological drivers, and ecosystem fluxes. Elevated groundwater availability resulting from groundwater‐surface water exchange at the riparian site enhanced the latent heat flux (LE, the energy form of evapotranspiration), which was sustained longer in the growing season. Interannual variation of dry season LE was small at the upland site, while at the riparian site contrasting river flow conditions resulted in large interannual variability in LE, with June LE of high‐flow years being 2.3 times that of low‐flow years. The 4‐year mean summer LE at the riparian site was 2.1 times larger than that at the upland site. Carbon uptake (NEP) and LE were well correlated at the upland site at the monthly and annual timescales, but at the riparian site enhanced LE due to shallow water table depth did not correspond to enhanced NEP. Our results demonstrate that enhanced groundwater availability modulated by river stage is a critical driver of land surface fluxes in semiarid riparian ecosystems.
Nitrous Oxide Formation by Corona Discharge: Isotopic Composition Measurements and Atmospheric Applications
Authors: Smith Mica C. , Carlstad Julia M. , Hunter P. Quinby , Randazzo John , Boering Kristie A. 
Published: March 2021

AbstractThe expanding use of nitrogen‐containing fertilizers in agriculture has led to an increase in N2O, an important greenhouse gas and ozone‐depleting substance, since preindustrial times. Isotopic measurements are a valuable tool to distinguish the contribution of different sources of N2O, but the isotopic composition of N2O formed in the low temperature plasma regimes in lightning has not previously been measured. Here, a corona discharge was generated in flowing or static zero air, and the N2O formed at discharge cell pressures from ∼0.1 to 10 Torr (∼13–1,300 Pa) at a discharge voltage of 5 kV and discharge current of 1,500 μA was collected and measured by isotope ratio mass spectrometry. Experiments were also conducted by varying the discharge current from 75 to 1,500 μA at ∼0.5 Torr (∼67 Pa) and 5 kV. The results show enrichments in 15N in product N2O of up to 32‰ relative to the reactant N2 and even larger enrichments in 15N of up to 77‰ at the central nitrogen atom. Depletions in 18O as large as −71‰ relative to reactant O2 were also measured. The isotope‐isotope relationships of the N2O produced in the corona discharge are distinct from those of other sources of N2O, suggesting that isotope measurements can be used to determine whether local or regional variations in the atmospheric concentration of N2O – such as the enhanced N2O levels measured in the upper tropical and subtropical troposphere during the HIPPO mission – can be attributed to lightning activity, soil emissions, or biomass burning.
Calving of a Large Greenlandic Tidewater Glacier has Complex Links to Meltwater Plumes and Mélange
Authors: Cook Samuel J. , Christoffersen Poul , Truffer Martin , Chudley Thomas R. , Abellán Antonio 
Published: March 2021

AbstractCalving and solid ice discharge into fjords account for approximately half of the annual net ice loss from the Greenland ice sheet, but these processes are rarely observed. To gain insights into the spatiotemporal nature of calving, we use a terrestrial radar interferometer to derive a 3‐week record of 8,026 calving events from Sermeq Kujalleq (Store Glacier, West Greenland), including the transition between a mélange‐filled and ice‐free fjord. We show that calving rates double across this transition and that the interferometer record is in good agreement with volumetric estimates of calving losses from contemporaneous unmanned aerial vehicle surveys. We report significant variations in calving activity over time, which obfuscate any simple power‐law relationship. While there is a statistically significant relationship between surface melt and the number of calving events, no such relationship exists between surface melt and the volume of these events. Similarly, we find a 70% increase in the number of calving events in the presence of visible meltwater plumes but only a 3% increase in calving volumes. While calving losses appear to have no clear single control, we find a bimodal distribution of iceberg sizes due to small blocks breaking off the subaerial part of the glacier front and large capsizing icebergs forming by full‐thickness failure. Whereas previous work has hypothesized that tidewater glaciers can be grouped according to whether they calve predominantly by the former or latter mechanism, our observations indicate that calving here inherently comprises both and that the dominant process can change over relatively short periods.
Influence of Thermal Stratification on Seasonal Net Ecosystem Production and Dissolved Inorganic Carbon in a Shallow Subtropical Lake
Authors: Lin Hao‐Chi , Chiu Chih‐Yu , Tsai Jeng‐Wei , Liu Wen‐Cheng , Tada Kazufumi , Nakayama Keisuke 
Published: March 2021

AbstractThermal stratification is a critical physical process controlling carbon (C) flux from lakes into the atmosphere. In general, vertical water temperature profiles in shallow subtropical lakes can vary significantly because typhoons frequently induce vertical mixing across the entire lake due to strong winds and rapid flushing from river inputs. Since C fluxes are driven by dissolved inorganic C (DIC), it is necessary to understand stratification's influence on DIC dynamics in shallow subtropical lakes. Therefore, we aimed to clarify the impact of stratification on DIC in Yuan‐Yang Lake, a typical shallow subtropical mountain lake, by developing a net ecosystem production (NEP) model. We measured the vertical profile of water temperature and DIC once or twice a month from July 2004 to December 2017. We applied a three‐dimensional hydrological model to estimate residence time and NEP, which revealed that large amounts of DIC are stored in the lower layer from spring to summer due to the suppression of vertical mixing by stratification. In autumn and winter, the lake was well mixed, and DIC was evenly distributed in the water column due to vertical mixing. This was confirmed by vertical DIC profiles.
Mantle Upwelling Beneath the Cathaysia Block, South China
Authors: He Chuansong , Santosh M. 
Published: March 2021

AbstractA large low‐velocity anomaly (LLVA) beneath the Cathaysia Block in South China that may be associated with mantle upwelling was revealed by seismic tomography. However, seismological and geological studies indicate that ascending mantle must have a higher temperature than the surrounding mantle, and a low‐velocity anomaly alone is not indicative of mantle upwelling. The receiver function technique has been used as a robust tool to characterize the topographic relief of the upper mantle discontinuities, which are closely related to temperature variations and mantle upwelling. In this study, we extracted 25,187 receiver functions and performed common‐conversion‐point stacking of those receiver functions in South China and across the location of the LLVA beneath the Cathaysia Block. The results show that the 410 km discontinuity is depressed and that the 660 km discontinuity is elevated at the location of the LLVA. The structure of the mantle transition zone seems to be the passage of an upwelling mantle plume, which implies that the LLVA is a signature of mantle upwelling.
Turbulence Structure and Momentum Exchange in Compound Channel Flows With Shore Ice Covered on the Floodplains
Authors: Wang Feifei , Huai Wenxin , Guo Yakun , Liu Mengyang 
Published: March 2021

AbstractIce cover formed on a river surface is a common natural phenomenon during the winter season in cold high latitude northern regions. For the ice‐covered river with compound cross‐section, the interaction of the turbulence caused by the ice cover and the channel bed bottom affects the transverse mass and momentum exchange between the main channel and floodplains. In this study, laboratory experiments are performed to investigate the turbulent flow of a compound channel with shore ice covered on the floodplains. Results show that the shore ice resistance restricts the development of the water flow and creates a relatively strong shear layer near the edge of the ice‐covered floodplain. The mean streamwise velocity in the main channel and on the ice‐covered floodplains shows an opposite variation pattern along with the longitudinal distance and finally reaches the longitudinal uniformity. The mixing layer bounded by the velocity inflection point consists of two layers that evolve downstream to their respective fully developed states. The velocity inflection point and strong transverse shear near the interface in the fully developed profile generate the Kelvin‐Helmholtz instability and horizontal coherent vortices. These coherent vortices induce quasi‐periodic velocity oscillations, while the dominant frequency of the vortical energy is determined through the power spectral analysis. Subsequently, quadrant analysis is used in ascertaining the mechanism for the lateral momentum exchange, which exhibits the governing contributions of sweeps and ejections within the vortex center. Finally, an eddy viscosity model is presented to investigate the transverse momentum exchange. The presented model is well validated through comparison with measurements, whereas the constants α and β appeared in the model need to be further investigated.
Ultrastable low-cost colloidal quantum dot microlasers of operative temperature up to 450 K
Authors: Chang Hao , Zhong Yichi , Dong Hongxing , Wang Zhenyu , Xie Wei , Pan Anlian , Zhang Long 
Published: March 2021

AbstractQuantum dot microlasers, as multifunctional optical source components, are of great importance for full-color high-pixel display, miniaturized coherent lighting, and on-chip integrated photonic and electronic circuits. Since the first synthesis of colloidal quantum dots (CQD) in the 1990s, motivation to realize high-performance low-cost CQD micro-/nanolasers has been a driving force for more than three decades. However, the low packing density, inefficient coupling of CQDs with optical cavities, and the poor thermal stability of miniaturized complex systems make it challenging to achieve practical CQD micro-/nanolasers, especially to combine the continuous working ability at high temperatures and the low-cost potential with mass-produced synthesis technologies. Herein, we developed close-packed CQD-assembled microspheres and embedded them in a silica matrix through the rapid self-aggregation and solidification of CdSe/ZnS CQD. This technology addresses the core issues of photoluminescence (PL) quenching effect and low optical gain in traditional CQD laser research. High-efficiency low-threshold CQD microlasers are demonstrated together with long-playing (40 min) working stability even at 450 K under pulsed laser excitation, which is the highest operational temperature for CQD lasers. Moreover, single-mode CQD microlasers are obtained with tunable wavelengths across the entire visible spectral range. The chemosynthesis process supports the mass-produced potential of high-density integrated CQD microlasers, promoting CQD-based low-cost high-temperature microdevices.
HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias
Authors: Mshaik Rony , Simonet John , Georgievski Aleksandra , Jamal Layla , Bechoua Shaliha , Ballerini Paola , Bellaye Pierre-Simon , Mlamla Zandile , Pais de Barros Jean-Paul , Geissler Audrey , Francin Pierre-Jean , Girodon François , Garrido Carmen , Quéré Ronan 
Published: March 2021

AbstractT-cell and B-cell acute lymphoblastic leukemias (T-ALL, B-ALL) are aggressive hematological malignancies characterized by an accumulation of immature T- or B-cells. Although patient outcomes have improved, novel targeted therapies are needed to reduce the intensity of chemotherapy and improve the prognosis of high-risk patients. Using cell lines, primary cells and patient-derived xenograft (PDX) models, we demonstrate that ALL cells viability is sensitive to NVP-BEP800, an ATP-competitive inhibitor of Heat shock protein 90 (HSP90). Furthermore, we reveal that lymphocyte-specific SRC family kinases (SFK) are important clients of the HSP90 chaperone in ALL. When PDX mice are treated with NVP-BEP800, we found that there is a decrease in ALL progression. Together, these results demonstrate that the chaperoning of SFK by HSP90 is involved in the growth of ALL. These novel findings provide an alternative approach to target SRC kinases and could be used for the development of new treatment strategies for ALL.