bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Model for the Coldwell Complex and Associated Dykes of the Midcontinent Rift, Canada
Authors: Good David J , Hollings Pete , Dunning Greg , Epstein Rachel , McBride John , Jedemann Andrew , Magnus Seamus , Bohay Trevor , Shore Geoff 
Published: April 2021

AbstractMafic intrusions on the NE shoulder of the Midcontinent Rift (Keweenawan LIP), including Cu–PGE mineralized gabbros within the Coldwell Complex (CC), and rift parallel or radial dykes outside the CC are correlated based on characteristic trace element patterns. In the Coldwell Complex, mafic rocks are subdivided into four groups: (1) early metabasalt; (2) Marathon Series; (3) Layered Series; (4) Geordie–Wolfcamp Series. The Marathon Series are correlated with the rift radial Abitibi dykes (1140 Ma), and the Geordie–Wolfcamp Series with the rift parallel Pukaskwa and Copper Island dykes. U–Pb ages determined for five gabbros from the Layered and Marathon Series are between 1107·7 and 1106·0 Ma. Radiogenic isotope ratios show near chondritic (CHUR) εNd(1106 Ma) and 87Sr/86Sri values that range from –0·38 to +1·13 and 0·702537 to 0·703944, respectively. Distinctive geochemical properties of the Marathon Series and Abitibi dykes, such as Ba/La (14–37), Th/Nb (0·06–0·12), La/Sm (3·8–7·7), Sr/Nd (21–96) and Zr/Sm (9–19), are very different from those of the Geordie–Wolfcamp Series and a subset of Copper Island and Pukaskwa dykes with Ba/La (8·7–11), Th/Nb (0·12–0·13), La/Sm (6·7–7·9), Sr/Nd (5–7·8) and Zr/Sm (18–24). Each unit exhibits covariation between incompatible element ratios such as Zr/Sm and Nb/La or Gd/Yb, Sr/Nd and Ba/La, and Nb/Y and Zr/Y, which are consistent with mixing relationship between two or more mantle domains. These characteristics are unlike those of intrusions on the NW shoulder of the MCR, but resemble those of mafic rocks occurring in the East Kenya Rift. The results imply that an unusual and long-lived mantle source was present in the NE MCR for at least 34 Myr (spanning the 1140 Ma Abitibi dykes and the 1106 Ma Marathon series) and indicate potential for Cu–PGE mineralization in an area much larger than was previously recognized.
Making a Research Infrastructure: Conditions and Strategies to Transform a Service into an Infrastructure
Authors: Fecher Benedikt , Kahn Rebecca , Sokolovska Nataliia , Völker Teresa , Nebe Philip 
Published: April 2021

AbstractIn this article, we examine the making of research infrastructures for digital research. In line with many scholars in this field, we understand research infrastructures as deeply relational and adaptive systems that are embedded in research practice. Our aim was to identify the relevant context factors, actor constellations, organizational settings, and strategies which contribute to the evolution of a basic service into an actual infrastructure. To this end, we conducted thirty-three case studies of non-commercial and commercial research services along the research life cycle. By examining how these services emerge, we hope to gain a better understanding of the conditions and strategies to transform a service into an infrastructure. We are able to identify competitive disadvantages for publicly financed infrastructure projects with regard to the mode of implementation and the resources invested in development and marketing. We suggest that the results of this study are of practical relevance, especially for individuals, communities, and organizations wanting to create research infrastructures, as well as for funders and policy makers wanting to support innovative and sustainable infrastructures.
The N300: An Index for Predictive Coding of Complex Visual Objects and Scenes
Authors: Kumar Manoj , Federmeier Kara D , Beck Diane M 
Published: April 2021

Abstract
Predictive coding models can simulate known perceptual or neuronal phenomena, but there have been fewer attempts to identify a reliable neural signature of predictive coding for complex stimuli. In a pair of studies, we test whether the N300 component of the event-related potential, occurring 250–350-ms poststimulus-onset, has the response properties expected for such a signature of perceptual hypothesis testing at the level of whole objects and scenes. We show that N300 amplitudes are smaller to representative (“good exemplars”) compared with less representative (“bad exemplars”) items from natural scene categories. Integrating these results with patterns observed for objects, we establish that, across a variety of visual stimuli, the N300 is responsive to statistical regularity, or the degree to which the input is “expected” (either explicitly or implicitly) based on prior knowledge, with statistically regular images evoking a reduced response. Moreover, we show that the measure exhibits context-dependency; that is, we find the N300 sensitivity to category representativeness when stimuli are congruent with, but not when they are incongruent with, a category pre-cue. Thus, we argue that the N300 is the best candidate to date for an index of perceptual hypotheses testing for complex visual objects and scenes.
Significant Variation in Blood Transfusion Practice Persists Following Adolescent Idiopathic Scoliosis Surgery
Authors: O’Malley Sandra M. , Sanders James O. , Nelson Susan E. , Rubery Paul T. , O’Malley Natasha T. , Aquina Christopher T. 
Published: April 2021

Study Design.
Retrospective case control study.

Objective.
To review current transfusion practise following Adolescent Idiopathic Scoliosis (AIS) surgery and assess risks of complication from transfusion in this cohort.

Summary of Background Data.
No study to date has investigated variation in blood transfusion practices across surgeons and hospitals following AIS surgery.

Methods.
Data were extracted from the Statewide Planning and Research Cooperative System. Using International Classification of Diseases (ICD-9) all patients with (ICD-9) code for AIS (737.30) (“idiopathic scoliosis”) and underwent spinal fusion between 2000 and 2015 were included. Bivariate and mixed-effects logistic regression analyses were performed to assess patient, surgeon, and hospital factors associated with perioperative allogeneic red blood cell transfusion. Additional multivariable analyses examined the association between transfusion and infectious complications.

Results.
Of the 7689 patients who underwent AIS surgery, 21.1% received a perioperative blood transfusion. After controlling for patient factors, wide variation in risk-adjusted transfusion rates was present with a 10-fold difference in transfusion rates observed across surgeons (4.4%–46.1%) and hospitals (5.1%–50%). Patient factors did not explain any of the surgeon or hospital variation. Use of autologous blood transfusion, higher surgeon procedure volume, and greater surgeon years in practice were independently associated with lower odds of allogeneic blood transfusion (P < 0.001), and surgeon and hospital characteristics explained 45% of surgeon variation but only 2.4% of hospital variation. Allogeneic blood transfusion was independently associated with postoperative wound infection (OR = 1.87, 95% CI = 1.20–2.93), pneumonia (OR = 1.68, 95% CI = 1.26–2.44), and sepsis (OR = 2.42, 95% CI = 1.11–5.83).

Conclusion.
Significant variation exists across both surgeons and hospitals in perioperative blood transfusion utilization following AIS surgery. Use of autologous blood transfusion and implementing institutional transfusion protocols may reduce unwarranted variation and potentially decrease infectious complication rates.

Level of Evidence: 3
Management of small bowel adenocarcinoma: making the most of the available evidence to inform routine practice
Authors: Mazlom Hadi , Teuwen Laure-Anne , Peeters Marc 
Published: April 2021

Purpose of review
Small bowel adenocarcinoma (SBA) is a rare disease, for which few studies have been conducted so far. Therefore, most treatment recommendations have been extrapolated from trials in colorectal cancer. In this review, we revise available data that could improve the management of SBA, with a particular focus on systemic therapy.

Recent findings
For advanced/irresectable disease, first-line doublet chemotherapy remains standard of care. It is uncertain whether extending treatment to triplet chemotherapy brings added benefit. Pembrolizumab is an accepted treatment modality for mismatch repair-deficient tumors, yet might also be active in microsatellite stable tumors. More trials with immunotherapy are underway. Although there is no place for anti-EGFR monotherapy, the addition of cetuximab to chemotherapy should be investigated further. Two trials suggest an added value of bevacizumab to chemotherapy, yet larger trials are needed to confirm these data. For localized disease, the role of (neo)adjuvant chemotherapy is under investigation.

Summary
For decades, patients with SBA have probably been treated suboptimal by basing treatment recommendations on data from colorectal cancer. An effort for SBA-specific trials and/or inclusion of SBA patients in basket trials is of utmost importance in order to improve outcome for these patients.
Artificial intelligence in bladder cancer prognosis: a pathway for personalized medicine
Authors: Pinar Ugo , Pradere Benjamin , Roupret Morgan 
Published: April 2021

Purpose of review
This review aims to provide an update of the results of studies published in the last 2 years involving the use of artificial intelligence in bladder cancer (BCa) prognosis.

Recent findings
Recently, many studies evaluated various artificial intelligence models to predict BCa evolution using either deep learning or machine learning. Many trials evidenced a better prediction of recurrence-free survival and overall survival for muscle invasive BCa (MIBC) for deep learning-based models compared with clinical stages. Improvements in imaging associated with the development of deep learning neural networks and radiomics seem to improve post neo-adjuvant chemotherapy response. One study showed that digitalized histology could predict nonmuscle invasive BCa recurrence.

Summary
BCa prognosis could be better assessed using artificial intelligence models not only in the case of MIBC but also NMIBC. Many studies evaluated its role for the prediction of overall survival and recurrence-free survival but there is still little data in the case of NMIBC. Recent findings showed that artificial intelligence could lead to a better assessment of BCa prognosis before treatment and to personalized medicine.
Loneliness, Death Perception, and Spiritual Well-Being in Adult Oncology Patients
Authors: Kavalalı Erdoğan Tuğba , Koç Zeliha 
Published: April 2021

Background
Holistic nursing care requires taking into consideration the spiritual and emotional dimensions of the patient.

Objective
The aim of this study was to determine the relationships among loneliness, death perception, and spiritual well-being in adult oncology patients.

Methods
This cross-sectional, descriptive-correlational study was conducted between March 20, 2018, and September 20, 2018. A total of 347 oncology inpatients participated in this study. Data were collected using the UCLA Loneliness Scale (UCLA-LS), the Personal Meanings of Death Scale, and the Functional Assessment of Chronic Illness Therapy–Spiritual Well-being Scale (FACIT-Sp).

Results
A significant negative relationship was found between UCLA-LS total scores and FACIT-Sp total scores (r = −0.217, P < .01). Positive significant relationships between FACIT-Sp total scores and the Afterlife (r = 0.425, P < .01), Motivation/Legacy (r = 0.468, P < .01), and Extinction (r = 0.337, P < .01) subdimension scores of the Personal Meanings of Death Scale were also found. Functional Assessment of Chronic Illness Therapy–Spiritual Well-being Scale total scores were affected by age (B = −0.158), having graduated from a university (B = −7.859), living in the city center (B = −5.607), current diagnosis (B = −0.416), surgical treatment (B = −5.291), and receiving chemotherapy (B = 5.304). The UCLA-LS scores were unrelated to the sociodemographic and clinical characteristics of the patients (P > .05).

Conclusion
Oncology patients experience moderate levels of loneliness, which decrease as their spiritual well-being levels increase. Patients with higher levels of spiritual well-being were found to attribute more positive meanings to death.

Implications for Practice
Spiritual well-being, loneliness, and death perception should be periodically evaluated in oncology patients, and appropriate nursing interventions should be planned.
Prostate-Specific Membrane Antigen Expression in Patients With Differentiated Thyroid Cancer With Thyroglobulin Elevation and Negative Iodine Scintigraphy Using 68Ga-PSMA-HBED-CC PET/CT
Authors: Verma Priyanka , Malhotra Gaurav , Meshram Vilas , Chandak Ashok , Sonavane Sunita , Lila Anurag R. , Bandgar Tushar R. , Asopa Ramesh V. 
Published: April 2021

Purpose of the Report
Prostate-specific membrane antigen (PSMA) is a member of superfamily of zinc-dependent exopeptidases that is robustly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature including microvessels of thyroid tumors. Its expression in differentiated thyroid cancer (DTC) has been confirmed in many recent studies, but systematic studies exploring PSMA expression in patients with DTC with thyroglobulin elevation and negative iodine scintigraphy (TENIS) are lacking. The aim of the present study was to evaluate the role of PSMA scan in TENIS patients with DTC.

Methods
Nine consecutive patients with DTC with proven TENIS syndrome (6 men and 3 women with age range 29–68 years and mean age of 48 years) underwent 18F-FDG PET/CT as per the institution protocol. Thereafter, they were subjected to 68Ga-PSMA-HBED-CC PET/CT as per the institution protocol within a week of FDG PET imaging. Prostate-specific membrane antigen expression (SUVmax) in the lesions was compared with 18F-FDG PET and CT scan findings.

Results
In 5 of 9 patients with TENIS, the metastatic lesions showed PSMA expression. A total of 14 lesions were seen on the CT scan. Prostate-specific membrane antigen PET detected 9 of 14 lesions (64.28%) (SUVmax ranging from 10.1 to 45.67; median SUVmax of 16.31), whereas FDG PET was positive in 11 of 14 lesions (78.57%). The lesions that showed PSMA uptake was localized to bones (5 of 9) and lungs (4 of 9). Two lesions that were localized to iliac crest and acetabulum were missed on FDG PET but were seen on CT and PSMA PET scan.

Conclusions
The results of this pilot study indicate that 68Ga-HBED-CC-PSMA PET/CT demonstrates PSMA expression in TENIS patients with lesions being localized to the bones and lungs. 68Ga-PSMA PET/CT could be useful for the identification of TENIS patients who might benefit from PSMA-targeted radionuclide therapy.
Efficacy and Safety of the 64Cu(II)Cl2 PET/CT for Urological Malignancies
Authors: Mascia Manlio , Villano Carlo , De Francesco Valerio , Schips Luigi , Marchioni Michele , Cindolo Luca 
Published: April 2021

Purpose of the Report
The aim of this study was to evaluate safety and efficacy of copper-64(II)dichloride (64Cu(II)Cl2) as a new PET tracer for urological malignancies (UMs).

Methods
Patients with UM were enrolled in a prospective study. All patients were staged with preoperative CT and 64Cu(II)Cl2 PET/CT. Patient characteristics, anatomical and functional imaging, and final histopathology were recorded. Surgical specimens for histopathological examination were collected. To determine time-activity curves for 64Cu(II)Cl2 uptake in UM and normal tissues, SUVs were calculated. The safety of 64Cu(II)Cl2 was assessed.

Results
Twenty-three patients were included. An administered activity of 174.7 MBq (4.72 mCi) for 64Cu(II)Cl2 was equal to 9.80 mSv of the effective dose. The median SUVmax values were 5.7, 0.9, 1.8, and 9.8 for the prostate, bladder, penis, and kidney, respectively. Median SUVmax values were higher in organs with a malignancy in comparison with healthy tissue (prostate [11.5 vs 5.3, P < 0.001], bladder [6.2 vs 0.9, P = 0.007], and penis [3.9 vs 1.3, P = 0.027]), but not in the kidneys (5.0 vs 10.4, P = 0.998). The highest area under the curve (AUC) was reported for prostate cancer (AUC, 0.978), and the lowest for penile cancer (AUC, 0.775). The detection rates based on the best suggested cutoff according to the SUVmax were 85.7% (6/7) for prostate and bladder and 83.3% (5/6) for penile cancer. Neither drug-related effects nor physiologic responses occurred, nor adverse reactions.

Conclusions

64Cu(II)Cl2 is an effective and well-tolerated tracer in patients with UM. Our results show higher SUVmax in cancer patients than in healthy subjects. Our findings suggest that 64Cu(II)Cl2 PET/CT is useful in patients affected by prostate, bladder, and penis cancer.
Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease
Authors: Yoon Hai-Jeon , Kim Bom Sahn , Jeong Jee Hyang , Kim Geon Ha , Park Hee Kyung , Chun Min Young 
Published: April 2021

Purpose
In typical Alzheimer disease with dementia (ADD), amyloid pathologies affect both cerebral hemispheres symmetrically. However, the spatial distribution of amyloid-β (Aβ) in the early stage of ADD or over the course of disease has not been investigated. Therefore, we explored asymmetric pattern of Aβ deposition in both hemispheres according to the ADD continuum using 18F-florbetaben PET.

Methods
Sixty-eight subjects, including 15 Aβ-negative normal controls, 28 Aβ-positive mild cognitive impairment (Aβ+ MCI), and 25 Aβ-positive ADD (Aβ+ ADD) subjects, were enrolled. Differences in the asymmetry index and SUV ratio in each of the 6 target regions (4 cortical lobes, cingulate, precuneus) plus composite region between groups were explored.

Results
The composite and target regional asymmetry indices were significantly different between groups and was highest in Aβ+ MCI (composite, occipital, and temporal, P < 0.001; frontal, P = 0.004). The composite and target regional SUV ratios were significantly different according to 3 groups with gradual increase and were highest in Aβ+ ADD (composite and all target regions, P < 0.001).

Conclusions
The asymmetric pattern of amyloid deposition was distinct between Aβ-negative normal controls and Aβ+ MCI. This pattern disappeared as the disease progressed. These data indicate that asymmetric amyloid deposition may be an early sign of MCI over the course of ADD.
Central Nervous System Involvement of Hemophagocytic Lymphohistiocytosis
Authors: Allard Bastien , Delcroix Olivier , Le Lez-Soquet Servane , Sacaze Elise , Querellou Solène 
Published: April 2021

Abstract
Hemophagocytic lymphohistiocytosis is rare life-threatening syndrome, hereditary or acquired, mainly affecting children. Hemophagocytic lymphohistiocytosis is an immune deficiency characterized by severe inflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages. The usual biological and clinical data may associate polyadenopathy, hepatosplenomegaly, fever, multivisceral damages, and cytopenias with potential multiorgan dysfunction and death. We report the case of a 4-year-old girl, hospitalized for recurrent cerebellar symptoms (ataxia) associated later with fever and pancytopenia. 18F-FDG PET/CT revealed a node pathological uptake, which was biopsied and confirmed a diagnosis of hemophagocytic lymphohistiocytosis.
Synchronous Bilateral Adrenal Gland Metastases of Bladder Carcinoma Revealed on 18F-FDG PET/CT
Authors: Erol Özge , Ergül Nurhan , Algün Gedik Arzu , Beyhan Ediz , Çermik Tevfik Fikret 
Published: April 2021

Abstract
Bilateral adrenal metastases from bladder carcinoma have been reported rarely. We report an 86-year-old man with urothelial bladder carcinoma who had received chemotherapy and radiotherapy. Bilateral synchronous adrenal gland metastases were observed on 18F-FDG PET/CT.
Secretory Leukocyte Proteinase Inhibitor Protects Acute Kidney Injury Through Immune and Non-Immune Pathways
Authors: Guerrieri Diego , Ambrosi Nella Gabriela , Romeo Horacio , Salaberry Juan , Toniolo María Fernanda , Remolins Carla , Incardona Claudio , Casadei Domingo , Chuluyan Eduardo 
Published: April 2021

ABSTRACT
Acute kidney injury (AKI) is characterized by rapid loss of excretory function and is the clinical manifestation of several disorders affecting the kidney. The aim of the present study was to investigate the mechanism of action of Secretory Leukocyte Proteinase Inhibitor (SLPI) that protects the kidneys form AKI. In vivo and in vitro experiments were performed to assess the effect of SLPI on kidney injury. Animal models of kidney injury was generated by 40 min obstruction of kidney artery and vein (ischemia-reperfusion injury model) or daily administration of 60 mg/kg/day of gentamicine for 5 day (gentamicin-associated AKI model). For in vitro assessment, human renal epithelium HK-2 cells were cultured under serum starvation conditions or with tacrolimus. The administration of SLPI (250 μg/kg, i.p.) reduced elevated plasma creatinine and blood urea nitrogen levels, tissue myeloperoxidase content, and acute tubular necrosis induced by kidney damage. Furthermore, SLPI treatment reduced CD86, CD68, CD14, CCL2, TNFα, and IL-10 transcripts in kidney biopsies. To further analyze a direct effect of SLPI on renal epithelial cells, HK-2 cells from human renal epithelium were cultured under serum starvation conditions or with tacrolimus. Both conditions induced apoptosis of HK-2 cells which was reduced when SLPI was present in the culture medium. Furthermore, SLPI favored the proliferation and migration of HK-2 cells. An analysis of the gene profiles of HK-2 cells treated with calcineurin inhibitors affected inflammatory and non-inflammatory pathways that were reversed by SLPI. Among them, SLPI down modulated the expression of CCL2, SLC5A3, and BECN1 but up-regulated the expression of TLR4, ATF4, ATF6, HSP90B, BBC3 SLC2A1, and TNFRSF10B. Overall, these results suggest that SLPI, in addition to its activity on immune cells, may directly target tubular epithelial cells of the kidney to mediate the nephroprotective activity in AKI.
Fluid Responsiveness Predictability in Immediate Postoperative Pediatric Cardiac Surgery. Is the Old Slandered Central Venous Pressure Back Again?
Authors: Shostak Eran , Shochat Tzippy , Manor Orit , Nahum Elchanan , Dagan Ovadia , Schiller Ofer 
Published: April 2021

ABSTRACT

Objective:
Acute low cardiac output (CO) is a frequent scenario in pediatric cardiac intensive care units (PCICU). While fluid responsiveness has been studied extensively, literature is scarce for the immediate postoperative congenital heart surgery population admitted to PCICUs. This study analyzed the utility of hemodynamic, bedside ultrasound, and Doppler parameters for prediction of fluid responsiveness in infants and neonates in the immediate postoperative cardiac surgery period.

Design:
A prospective observational study.

Setting:
University affiliated, tertiary care hospital, PCICU.

Participants:
Immediate postoperative pediatric patients displaying a presumed hypovolemic low CO state were included. A clinical, arterial derived, hemodynamic, sonographic, Doppler-based, and echocardiographic parameter assessment was performed, followed by a fluid bolus therapy.

Interventions:
Fifteen to 20 cc/kg crystalloid fluid bolus.

Main outcome measures:
Fluid responsiveness was defined as an increase in cardiac index >10% by echocardiography.

Results:
Of 52 patients, 34 (65%) were fluid responsive. Arterial systolic pressure variation, continuous-Doppler preload parameters, and inferior vena-cava distensibility index (IVCDI) by bedside ultrasound all failed to predict fluid responsiveness. Dynamic central venous pressure (CVP) change yielded a significant but modest fluid responsiveness predictability of area under the curve 0.654 (P = 0.0375).

Conclusions:
In a distinct population of mechanically ventilated, young, pediatric cardiac patients in the immediate postoperative period, SPV, USCOM preload parameters, as well as IVC-based parameters by bedside ultrasound failed to predict fluid responsiveness. Dynamic CVP change over several hours was the only parameter that yielded significant but modest fluid responsiveness predictability.