bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-P53 Textbook outcomes in pancreatoduodenectomy are improved in high volume specialist pancreas-only centres
Authors: Vedamanickam Pon Rachel , McKay Siobhan C , Raza Soulat , Laing Richard , Bhatt Anand , Durkin Damien , Athwal Tejinderjit 
Published: December 2021

Abstract

Background
Traditional single surgical quality indicators are commonly used however they are poor for assessing global outcomes for patients. Composite outcomes such as the ‘Textbook Outcome’ (TO) is a composite outcome to determine the success of the quality of the surgical process, and compare outcomes between institutions and patient groups, described by the Dutch Pancreatic Cancer Audit Group for Pancreatoduodenectomy (PD). They reported national TOs for PD of 58.3%, we compared this to TOs in a UK high volume specialist pancreas-only centre, Royal Stoke.

Methods
Patients who underwent PD from January 2017 to December 2020 were identified from our database. TO was defined as absence the following: post-operative pancreatic fistula (POPF) (grade B/C), post-pancreatectomy haemorrhage (PPH), bile leak, severe complications (Clavien Dindo grade III or more), 30-day readmission and 30-day mortality.

Results
153 patients underwent PD during the 4-year study period. The median age was 71years (range 37-85 years), and there was a slight male preponderance (54.9%, 84/153). 47% had pancreatic ductal adenocarcinoma (72/153), 17% ampullary carcinoma (26/153), 9% cholangiocarcinoma (14/153), 9% duodenal carcinoma (14/153), and benign pathology included cases with IPMN and duodenal polyps with high grade dysplasia. There was a statistically significant difference in textbook outcome in our cohort compared to the Dutch Study (70.3%, 108/153 vs 58.3%, 895/1536; p=0.003086), with components of TO shown in Figure 1.

Conclusions
TO represent composite outcome for identifying good practice, areas for shared learning and areas for improvement. PD performed in high-volume pancreas-only specialist centers appear to have better outcomes following PD than lower-volume centres. Further investigation is required to assess why outcomes are different between centres, and identify how best practice can be shared.
P-P55 CT-PET use in potentially resectable pancreatic cancer
Authors: Thorne Thomas , McKay Siobhan C , Hall Lewis , Wilkin Richard , Pathak Samir , Barrie Jenifer , Moir John , Roberts Keith J ,   on behalf of the Surg-Panc-UK Study Group
Published: December 2021

Abstract

Background
CT-PET has become increasingly used in the diagnostic pathway for pancreatic cancer (PC)and was introduced into National Guidelines (NICE) in 2018 in the United Kingdom. It can improve the diagnosis of metastatic disease, though some believe it is not significantly better than a staging CT and MRI, and there are concerns that it can significantly delay the treatment pathway for patients, without adding benefit.

Methods
A retrospective national study undertaken by 26/27 specialist pancreatic resectional centres in the United Kingdom. All adult patients listed for pancreatoduodenectomy for suspected PC were included. Baseline demographics, length of pathway (days from MDT to surgery), number and type of investigations, interventions (ERCP or PTC) and associated complications were recorded, in addition to the operation performed and 12-month survival. Patients undergoing neoadjuvant chemotherapy were excluded.

Results
1709 cases were entered from 2017-2020. 155 patients were excluded due to neoadjuvant chemotherapy, with 8 further patients excluded due to incomplete data entry. The median age was comparable for patients undergoing CT-PET (68 years IQR 60.0-73.0) and those who did not undergo CT PET (68 years IQR 60.0-74.0). 363/1546 patients (23.5%) underwent a pre-operative CT-PET. There was a significantly longer pathway with CT-PET (56 vs 42 days, p &lt; 0.001) and a non-significant tendency towards an increased bypass rate with CT-PET (9.9% vs. 7.8%, p = 0.065), and no improvement in survival (1-year survival 76.9% vs 75.7%, p = 0.712).

Conclusions
There is a statistically significant increase in the length of pathway with CT-PET, without any improvement in bypass rate or one year survival compared the no-CT-PET group. CT-PET undoubtedly has benefits but should be used selectively rather as standard investigation for all patients as failed to demonstrate survival improvement.
Visiting Plants of Mamestra brassicae (Lepidoptera: Noctuidae) Inferred From Identification of Adhering Pollen Grains
Authors: Guo Jianglong , Liu Yongqiang , Jia Huiru , Chang Hong , Wu Kongming 
Published: December 2021

Abstract
Numerous lepidopteran adults frequently pick up plant pollen when feeding. Identifying plant species visited by Mamestra brassicae moths could further strengthen our knowledge of their migratory trajectory and the interactions of M. brassicae moths with these plant species. Here, with morphological analysis and DNA metabarcoding of pollen carried by the moths, we determined these plant species visited by M. brassicae during 2015–2018. Pollen grains removed from M. brassicae moths were identified from 25 species (18 were identified to genus), representing at least 19 families, including Pinaceae, Oleaceae, Rosaceae, and Asteraceae, but mainly belonging to Angiospermae, Dicotyledoneae. There were noticeable interannual differences (maximum value: 35.31% in 2018) and seasonal differences (maximum value: 33.28% in April–(including May)–June) in the frequency of M. brassicae moths with adhering pollen, but no noticeable difference based on sex. Meanwhile, we also found pollen from some species such as Citrus sinensis (Rutales: Rutaceae) and Melia azedarach (Rutales: Meliaceae) that grow in southern China, indicating that M. brassicae moths might migrate northward in spring. Our results demonstrate that the M. brassicae moth visits a variety of plant species during migration, and these findings promote our understanding of the interaction between moths and these plant species.
Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator
Authors: Marin-Cuartas Mateo , Zhu Yuanjia , Imbrie-Moore Annabel M , Park Matthew H , Wilkerson Robert J , Leipzig Matthew , Pandya Pearly K , Paulsen Michael J , Borger Michael A , Woo Y Joseph 
Published: December 2021

AbstractOBJECTIVESThe severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood. Using a novel ex vivo model, we sought to study acute PM rupture to improve clinical management.METHODSUsing porcine mitral valves (n = 32) mounted within an ex vivo left heart simulator, PM rupture was simulated. The mitral valve was divided into quadrants for analysis according to the PM heads. Acute PM rupture was simulated by incrementally cutting from 1/3 to the total number of chordae arising from 1 PM head of interest. Haemodynamic parameters were measured.RESULTSRupture &gt;2/3 of the chordae from 1 given PM head or regurgitation fraction &gt;60% led to markedly deteriorated haemodynamics. Rupture at the anterolateral PM had a stronger negative effect on haemodynamics than rupture at the posteromedial PM. Rupture occurring at the anterior head of the anterolateral PM led to more marked haemodynamic instability than rupture occurring at the other PM heads.CONCLUSIONSThe haemodynamic effects of acute PM rupture vary considerably according to the site and extent of the rupture. Rupture of ≤2/3 of chordae from 1 PM head or rupture at the posteromedial PM lead to less marked haemodynamics effects, suggesting a higher likelihood of tolerating surgery. Rupture at the anterolateral PM, specifically the anterior head, rupture of &gt;2/3 of chordae from 1 PM head or regurgitation fraction &gt;60% led to marked haemodynamic instability, suggesting the potential benefit from bridging strategies prior to surgery.
Fragmentation of Cannabinoids by Flow Injection Analysis Tandem Mass Spectrometry (FIA–MS/MS)
Authors: Büttenbender Sabrina Laíz , Carvalho Ânderson Ramos , de Souza Barbosa Fábio , Scorsatto Ortiz Rafael , Limberger Renata Pereira , Mendez Andreas S L 
Published: December 2021

Abstract

Background
The analysis of plant material from Cannabis sativa L. has long been targeted on its main psychologically active metabolite, Δ9-tetrahydrocannabinol (THC). In addition to the diverse plant composition and medicinal interest in several cannabinoids, these compounds may also be related to the different characteristics of samples sold illegally. Currently, it is indisputable that other cannabinoids should also be considered in cannabis assays. Mass spectrometry has been used to identify and characterize substances in the most different scenarios, and knowing the analyte fragmentation profile is essential for characterizing samples of diverse origin.

Objective
In this work, flow injection analysis–tandem mass spectrometry with electrospray ionization (FIA–ESI-MS/MS) in positive and negative modes was used to evaluate the fragmentation profiles of eight cannabinoids commonly found in cannabis samples: THC, tetrahydrocannabinolic acid, Δ8-tetrahydrocannabinol, cannabidiol, cannabidiolic acid, cannabigerol, cannabigerolic acid and cannabinol.

Methods
By exploring the fragmentation data from mass spectrometry, the samples were classified using a chemometric model of partial least squares discriminant analysis (PLS-DA).

Results
When ESI in negative mode is used with adequate collision energies, it is possible to identify differences in the fragmentation of isomers. Based on that, chemometric tools were employed to classify different samples. The PLS-DA applied to FIA–ESI-MS/MS data yielded satisfactory classification.

Conclusion
Thus, the results presented can be applied as a preliminary tool in the analysis of unknown samples, guiding more accurate investigations in terms of chemical composition.

Highlights
This study of the cannabinoid fragmentation pattern by flow injection MS showed that cannabinoids can be distinguished by their fragmentation spectra after negative electrospray ionization. Multivariate data analysis (PLS-DA) allowed classification of different cannabis samples.
Introduction to the Supplement: Is Now the Time for the Future of Cancer Economics Research?
Authors: Halpern Michael T 
Published: December 2021

Abstract
The National Cancer Institute’s Division of Cancer Control and Population Sciences hosted a virtual conference, The Future of Cancer Health Economics Research, in December 2020. This conference brought together a multidisciplinary group of researchers and other stakeholders interested in supporting and developing the field of cancer health economics research to help improve both patient outcomes and health-care systems. The introduction to the supplement describes the origins and planning for the conference and the conference sessions and presentations. The papers included in this supplement, arising from the conference sessions, help strengthened our understanding of what is cancer health economics research and how this field can provide even greater contributions in the future.
Outcome of ABO-Incompatible Kidney Transplantation According to ABO Type of Transfused Plasma: Comparative Analysis Between “Universal” AB and Donor-Type Plasma
Authors: Kim Han Joo , Kim Jin Seok , Yang John Jeongseok , Chung Yousun , Kim Hyungsuk , Shin Sung , Kim Young Hoon , Hwang Sang-Hyun , Oh Heung-Bum , Han Duck-Jong , Kwon Hyunwook , Ko Dae-Hyun 
Published: December 2021

Abstract

Objective
We compared the clinical outcomes of recipients of ABO-incompatible (ABOi) kidney transplantation (KT) according to the blood group of the plasma transfused.

Materials and Methods
We retrospectively analyzed the data of 60 recipients of ABOi-KT with blood type O and A or B donors. Demographic and clinical characteristics were compared between 2 groups of recipients: 1 group received AB plasma regardless of the donor’s blood type (n = 30), and the other group received donor-type plasma (n = 30).

Results
There were no significant differences between the groups in terms of demographic characteristics. Transfusion of donor-type plasma was noninferior to transfusion of type AB plasma in terms of both rejection-free survival and rejection rate (P = .455, P = .335).

Conclusion
There was no significant prognostic difference between the 2 groups. In terms of blood supply and inventory management, we suggest that the blood group of the plasma should match the donor’s type.
Calm Reflections Under Hot Demand: Do Single Women in China Have Reproductive Freedom?
Authors: Yang Peiru , Chen Xi 
Published: December 2021

Abstract
This article discusses what would happen if a single woman in China wants to have children but not to marry. The legal framework regarding the reproductive rights of single women and relevant judicial practice will be discussed. In China, domestic legislation fails to regulate the reproductive rights in a uniform and systematic way. Although reproductive freedom has been granted to women by law in principle, single women have been excluded by many specific provisions governing the realisation of reproductive rights. To be specific, unlike couples, single women in China have little access to the application of assisted reproduction technology or the maternity insurance benefits. This puts them in a difficult position while exercising their reproductive rights. Although the legal basis of single women’s reproductive rights has been emphasised by international and domestic legal instruments around the world, in China, ambiguous laws, inadequate supporting measures, and negative social opinions pose many legal and ethical obstacles that need to be overcome. This article puts forward some suggestions for improvement.
Declarative continuous reasoning in the cloud-IoT continuum
Authors: Forti Stefano , Bisicchia Giuseppe , Brogi Antonio 
Published: December 2021

AbstractDeveloping and releasing multiservice applications rely upon a pipeline of automation tools known as Continuous Integration/Continuous Deployment. Among those tools, continuous reasoning is exploited by large companies to perform incremental static analyses on their code commits as soon as they are integrated into a shared codebase. In this article, we extend continuous reasoning towards the continuous QoS- and context-aware management of multiservice applications in Cloud-IoT scenarios. We propose a novel continuous reasoning methodology that supports runtime decision on service placement by reacting both to changes in the infrastructure and in the application requirements, and capable of suggesting migrations only for services affected by such changes. The methodology is prototyped in Prolog and assessed through simulations over a realistic use case and over a lifelike motivating scenario at increasing infrastructure sizes. Experimental results show that our approach brings considerable speed-up in comparison with an exhaustive search employing non-incremental reasoning.
Materialism and the Moral Status of Animals
Authors: Birch Jonathan 
Published: December 2021

AbstractConsciousness has an important role in ethics: when a being consciously experiences the frustration or satisfaction of its interests, those interests deserve higher moral priority than those of a behaviourally similar but non-conscious being. I consider the relationship between this ethical role and an a posteriori (or ‘type-B’) materialist solution to the mind-body problem. It is hard to avoid the conclusion that, if type-B materialism is correct, then the reference of the concept Phenomenal Consciousness is radically indeterminate between a neuronal-level property that is distinctive to mammals and a high-level functional property that is much more widely shared. This would leave many non-mammalian animals (such as birds, fish, insects and octopuses) with indeterminate moral status. There are ways to manage this radical moral indeterminacy, but all of these ways lead to profoundly troubling consequences.
Pilot study of food-specific go/no-go training for overweight individuals: brain imaging data suggest inhibition shapes food evaluation
Authors: Yang Yingkai , Morys Filip , Wu Qian , Li Jiwen , Chen Hong 
Published: December 2021

AbstractFood-specific go/no-go training might reduce overeating and facilitate weight loss. In this pilot study, we examined whether a food-specific go/no-go training over five weeks, as compared to a non-food-specific training, could produce changes in behavioral and neural responses to food images and body weight. Here, we used a sample of 51 overweight participants divided into training and control groups whose brain activity and food evaluation were measured before and after the training. Compared with the control group, in the training group we found significant reductions in high-calorie food evaluation. We also found lower activations in inhibitory control- and reward-related brain regions in response to high-calorie food images. Further, activation change of the mid-insula in response to the high-calorie food images was positively associated with change in the evaluation of those images. However, we found no evidence for a significant effect of food-specific go/no-go training on body weight change. Our findings highlight that food-specific go/no-go training in overweight individuals can reduce high-calorie food evaluation, but also neural activations in inhibitory control- and reward- related brain regions.
Second messengers mediating high-molecular-weight hyaluronan–induced antihyperalgesia in rats with chemotherapy-induced peripheral neuropathy
Authors: Bonet Ivan J. M. , Staurengo-Ferrari Larissa , Araldi Dionéia , Green Paul G. , Levine Jon D. 
Published: December 2021

Abstract
High-molecular-weight hyaluronan (HMWH) is an agonist at cluster of differentiation (CD)44, the cognate hyaluronan receptor, on nociceptors, where it acts to induce antihyperalgesia in preclinical models of inflammatory and neuropathic pain. In the present experiments, we studied the CD44 second messengers that mediate HMWH-induced attenuation of pain associated with oxaliplatin and paclitaxel chemotherapy-induced peripheral neuropathy (CIPN). While HMWH attenuated CIPN only in male rats, after ovariectomy or intrathecal administration of an oligodeoxynucleotide (ODN) antisense to G protein–coupled estrogen receptor (GPR30) mRNA, female rats were also sensitive to HMWH. Intrathecal administration of an ODN antisense to CD44 mRNA markedly attenuated HMWH-induced antihyperalgesia in male rats with CIPN induced by oxaliplatin or paclitaxel. Intradermal administration of inhibitors of CD44 second messengers, RhoA (member of the Rho family of GTPases), phospholipase C, and phosphatidylinositol (PI) 3-kinase gamma (PI3Kγ), attenuated HMWH-induced antihyperalgesia as does intrathecal administration of an ODN antisense to PI3Kγ. Our results demonstrated that HMWH induced antihyperalgesia in CIPN, mediated by its action at CD44 and downstream signaling by RhoA, phospholipase C, and PI3Kγ.
Survival Outcomes and Clinicopathological Features in Inflammatory Bowel Disease-associated Colorectal Cancer
Authors: Lu Can , Schardey Josefine , Zhang Tao , Crispin Alexander , Wirth Ulrich , Karcz Konrad W. , Bazhin Alexandr V. , Andrassy Joachim , Werner Jens , Kühn Florian 
Published: December 2021

Objective:
The aim of our study was to conduct a systematic review and meta-analysis comparing the survival outcomes of IBD-associated and non-IBD-associated CRC.

Summary of Background Data:
Investigations comparing the prognosis in CRC patients with and without IBD have yielded conflicting results.

Methods:
PubMed/MEDLINE, Embase, Web of Science, Cochrane Library were searched for studies evaluating the prognostic outcomes between CRC patients with IBD and those without IBD. Estimates of survival-related outcomes and clinicopathological features in IBD-CRC and non-IBD CRC were pooled through random-effects or fix-effects models. The study is registered with PROSPERO, CRD42021261513.

Results:
Of 12,768 records identified, twenty-five studies with 8034 IBD-CRC and 810,526 non-IBD CRC patients were included in the analysis. IBD-CRC patients have a significant worse overall survival (OS) with the hazard ratio (HR) of 1.33 [95% confidence interval (CI): 1.20–1.47] than those without IBD. Pooled estimates of cancer-specific survival demonstrated that IBD-CRC patients had a poorer cancer-specific survival than those without IBD with fixed-effect model (HR, 2.17; 95% CI: 1.68–2.78; P < 0.0001). Moreover, ulcerative colitis-associated CRC patients have favorable OS than Crohn’s disease-associated CRC (HR 0.79,95% CI: 0.72–0.87). Compared to non-IBD-CRC, patients with IBD-associated CRC are characterized by an increased rate of poor differentiation (OR 2.02, 95% CI: 1.57–2.61), mucinous or signet ring cell carcinoma (OR 2.43, 95% CI: 1.34–4.42), synchronous tumors (OR 3.18, 95% CI: 2.26–4.47), right-sided CRC (OR 1.62, 95%CI: 1.05–2.05), male patients (OR 1.10, 95% CI: 1.05–1.16), and a reduced rate of R0 resections (OR 0.60, 95% CI: 0.44–0.82).

Conclusions:
IBD-CRC patients have a significant worse OS than patients with non-IBD CRC, which may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site. Optimized therapeutic standards and tailored follow-up strategies might improve the prognosis of IBD-CRC patients.
Roseococcus microcysteis sp. nov., isolated from a Microcystis aeruginosa culture sample
Authors: Kim Wonjae , Kim Minkyung , Park Woojun 
Published: December 2021

Strain NIBR12T (=KACC 22094T=HAMBI 3739T), a novel Gram-stain-negative, obligate aerobic, non-spore-forming, non-motile and coccobacillus-shaped bacterium, was isolated from a cyanobacterial sample culture (Microcysitis aeruginosa NIBRCYC000000452). The newly identified bacterial strain grew optimally in modified Reasoner's 2A medium under the following conditions: 0 % (w/v) NaCl, pH 7.5 and 35 °C. Phylogenetic analysis using the 16S rRNA gene sequence confirmed that strain NIBR12T belongs to the genus

Roseococcus

, with its closest neighbours being

Roseococcus suduntuyensis

SHETT (98.8%),

Roseococcus thiosulfatophilus

RB-3T (97.7%), “Sediminicoccus rosea” R-30T (95.7 %) and

Rubritepida flocculans

H-8T (95.0 %). Genomic comparison of strain NIBR12T with type species in the genus

Roseococcus

was conducted using digital DNA–DNA hybridization, average nucleotide identity and average amino acid identity analyses, resulting in values of ≤53.7, ≤93.7 and ≤96.1 %, respectively. The genomic DNA G+C content of strain NIBR12T was 70.9 mol%. The major fatty acids of strain NIBR12T were summed feature 8 (C18 : 1
ω7c and/or C18:1
ω6c) and summed feature 3 (C16 : 1
ω6c/C16 : 1
ω7c). Q-9 was its major respiratory quinone. Moreover, the major polar lipids of strain NIBR12T were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and phosphatidylcholine. Based on our chemotaxonomic, genotypic and phenotype analyses, strain NIBR12T is identified as represeting a novel species of the genus

Roseococcus

, for which the name Roseococcus microcysteis sp. nov. is proposed.