bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evolutionarily Mismatched Impact of Urbanization on Insomnia Symptoms: a Short Review of the Recent Literature
Authors: O Jiaqing , Pugh-Jones Catrin , Clark Bethany , Trott Jenna , Chang Lei 
Published: April 2021

Abstract
Purpose of Review
For the most part of human existence, individuals have been living a rural lifestyle in a rural setting. However, such sleep-conducive conditions have largely been transformed dramatically by urbanization within a relatively short span of time in recent history, and the resulting evolved mechanisms-environment mismatch is theorized to bring about an increased risk for insomnia symptoms. This brief review of the recent literature is designed to evaluate the veracity of this proposition.

Recent Findings
The majority of recent findings have suggested that most proposed evolutionarily mismatched urban factors are indeed related to the presence of insomnia symptoms. However, there is a general paucity of longitudinal evidence (and for some other factors, a lack of enough evidence of any kind).

Summary
Although there is a preponderance of recent findings indicating a link between evolutionarily mismatched urban phenomena and insomnia symptoms, more longitudinal data are needed before any causative conclusion can be drawn.
Melittin, a honeybee venom derived peptide for the treatment of chemotherapy-induced peripheral neuropathy
Authors: Tender Tenzin , Rahangdale Rakesh Ravishankar , Balireddy Sridevi , Nampoothiri Madhavan , Sharma K. Krishna , Raghu Chandrashekar Hariharapura 
Published: April 2021

Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of cancer treatment which involves sensory and motor nerve dysfunction. Severe CIPN has been reported in around 5% of patients treated with single and up to 38% of patients treated with multiple chemotherapeutic agents. Present medications available for CIPN are the use of opioids, nonsteroidal anti-inflammatory agents, and tricyclic antidepressants, which are only marginally effective in treating neuropathic symptoms. In reality, symptom reappears after these drugs are discontinued. The pathogenesis of CIPN has not been sufficiently recognized and methods for the prevention and treatment of CIPN remain vulnerable to therapeutic problems. It has witnessed that the present medicines available for the disease offer only symptomatic relief for the short term and have severe adverse side effects. There is no standard treatment protocol for preventing, reducing, and treating CIPN. Therefore, there is a need to develop curative therapy that can be used to treat this complication. Melittin is the main pharmacological active constituent of honeybee venom and has therapeutic values including in chemotherapeutic-induced peripheral neuropathy. It has been shown that melittin and whole honey bee venom are effective in treating paclitaxel and oxaliplatin-induced peripheral neuropathy. The use of melittin against peripheral neuropathy caused by chemotherapy has been limited despite having strong therapeutic efficacy against the disease. Melittin mediated haemolysis is the key reason to restrict its use. In our study, it is found that α-Crystallin (an eye lens protein) is capable of inhibiting melittin-induced haemolysis which gives hope of using an appropriate combination of melittin and α-Crystallin in the treatment of CIPN. The review summarizes the efforts made by different research groups to address the concern with melittin in the treatment of chemotherapeutic-induced neuropathy. It also focuses on the possible approaches to overcome melittin-induced haemolysis.

Graphic Abstract
A new antisarcoma strategy: multisubtype heat shock protein/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors
Authors: Li H. , Sui X. , Wang Z. , Fu H. , Wang Z. , Yuan M. , Liu S. , Wang G. , Guo Q. 
Published: April 2021

AbstractOsteosarcoma, a common malignant tumor in orthopedics, often has a very poor prognosis after lung metastasis. Immunotherapy has not achieved much progress in the treatment because of the characteristics of solid tumors and immune environment of osteosarcoma. The tumor environment is rather essential for sarcoma treatment. Our previous study demonstrated that heat shock proteins could be used as antitumor vaccines by carrying tumor antigen peptides, and we hypothesize that an anti-osteosarcoma effect may be increased with an immune check point inhibitor (PD-L1 inhibitor) as a combination treatment strategy. The present study prepared a multisubtype mixed heat shock protein osteosarcoma vaccine (mHSP/peptide vaccine) and concluded that the mHSP/peptide vaccine was more effective than a single subtype heat shock protein, like Grp94. Therefore, we used the mHSP/peptide vaccine in combination with a PD-L1 inhibitor to treat osteosarcoma, and the deterioration of osteosarcoma was effectively hampered. The mechanism of combined therapy was investigated, and AKT expression participates with sarcoma lung metastasis. This study proposed an antisarcoma strategy via stimulation of the immune system as a further alternative approach for sarcoma treatment and elucidated the mechanism of combined therapy.
Navigating Trust and Distrust in the Refugee Community of Malta
Authors: Gandolfo Luisa 
Published: April 2021

AbstractThis article considers how trust is constructed in the refugee community of Malta, against the backdrop of ongoing and recurrent unrest in Libya. As social trust is re-evaluated, social spaces have become sites of tension where divisions re-emerge along political, ideological, and economic lines. By focusing on the Libyan diaspora, the article presents an insight into the ways that conflict trauma shapes trust-building, and considers the challenges faced by civil society organisations and government bodies in their efforts to facilitate support and community-building on the island. The article is based on 14 interviews conducted in 2015 with members of the Libyan diaspora, and Maltese civil society organisations and government bodies. The interviewees discussed the multifaceted aspects of trust-building, including the legacy of 42 years of political distrust during the regime of the former Libyan leader, Muammar Gaddafi, regional affiliations and divisions, and the continuum of trauma that unfolds in the Maltese Open Centres and in the host community. The findings of the study indicate that there are additional structural impediments that extend beyond the ongoing conflict, including the Maltese detention process, the redrawing of political boundaries around social spaces in the towns, and the role of identity, which present determining factors in the building of social trust. Collectively, these aspects hold implications for integration into the diaspora community on the island, while in the long term, individual recovery from conflict trauma is dependent on the trust-networks that are constructed, or joined, by the refugees.
Optimizing contrast-enhanced echocardiography by employing a sonographer driven protocol
Authors: Usry Courtney R. , Shin Satoshi R. , Aden James K. , Gore Rosco 
Published: April 2021

Abstract
Background
The use of enhancing agents in echocardiography has been shown to facilitate improved study quality. Despite the known benefits, its use remains limited by institutional policies.

Methods
We aimed to retrospectively evaluate if allowing sonographers to place a peripheral intravenous catheter and administer enhancing agent led to a decrease in time to complete outpatient transthoracic echocardiograms in comparison to using nursing personnel. Three separate protocols were employed. The ‘nurse driven protocol’ utilized nurses to place a peripheral intravenous catheter and inject enhancing agent. In a ‘mixed protocol,’ a nurse placed a peripheral intravenous catheter and the sonographer gave the enhancing agent. The ‘sonographer driven protocol’ involved the sonographer placing the peripheral intravenous catheter and delivering enhancing agent.

Results
A total of 232 echocardiograms were included for analysis. Patient characteristics across the three protocols were not statistically significant. The ‘mixed protocol’ had an average study time that was significantly less than the ‘nurse driven protocol’ (49.4 min ± 11.4 vs 54.6 min ± 12.9; p = 0.024). The ‘sonographer driven protocol’ also showed a significant reduction in study time (50.3 min ± 12.6) when compared to the ‘nurse driven protocol’ (p = 0.017). The additional task for the sonographer to place the peripheral intravenous catheter did not significantly increase the time to complete the study.

Conclusion
Allowing sonographers to administer enhancing agent reduced individual echocardiogram study times by approximately 5 min, supporting that a ‘sonographer driven protocol’ is more efficient with potential downstream economic benefits.
Effect of galena contained in dust from Zn–Pb metallurgical processes on environment
Authors: Nowińska Katarzyna , Adamczyk Zdzisław 
Published: April 2021

AbstractThis paper assesses the effect of galena emitted with dust from an electrostatic precipitator at Miasteczko Śląskie Zinc Smelting Plant (Poland) onto a soil and water environment. The Eh–pH diagrams plotted in the temperature range of − 3 to 25 °C serve to determine the conditions of PbS stability and conditions under which its decomposition may occur, resulting in the release of ionic forms of lead into the soil and water environment. Determination of the mobility of galena emitted with metallurgical dust is a current and important issue in view of the geochemistry of mineral components in the environment.
High-order compact LOD methods for solving high-dimensional advection equations
Authors: Hou Bo , Ge Yongbin 
Published: April 2021

AbstractIn this paper, by using the local one-dimensional (LOD) method, Taylor series expansion and correction for the third derivatives in the truncation error remainder, two high-order compact LOD schemes are established for solving the two- and three- dimensional advection equations, respectively. They have the fourth-order accuracy in both time and space. By the von Neumann analysis method, it shows that the two schemes are unconditionally stable. Besides, the consistency and convergence of them are also proved. Finally, numerical experiments are given to confirm the accuracy and efficiency of the present schemes.
Support of Dynamic Measurements Through Similitude Formulations
Authors: Casaburo A. , Petrone G. , Meruane V. , Franco F. , De Rosa S. 
Published: April 2021

AbstractUp to now, similitude methods have been used in order to overcome the typical drawbacks of experimental testing and numerical simulations by reconstructing the full-scale model behavior from that of the scaled model. The novelty of this work is the application of similitude theory not as a tool for predicting the prototype dynamic response, but for supporting, and eventually validating, experimental measurements polluted by noise. Two Aluminium Foam Sandwich (AFS) plates are analyzed with Digital Image Correlation (DIC) cameras. First, an algorithm for blind source separation problems is used to extract information about the excitation; then, SAMSARA (Similitude and Asymptotic Models for Structural-Acoustic Research Applications) similitude method is applied to both the force spectra and velocity responses of prototype and model. The reconstruction of force and velocity curves demonstrates that the similitude results are coherent with the quality of the experimental measurements: when the spatial pattern in resonance is recognizable, then the curves overlap. Instead, when the displacement field of just one model is not well identified, the reconstruction exhibits discrepancies. Therefore, similitude methods reveal to be an interesting tool for understanding if a set of measurements is reliable or not and their application should not be underestimated, especially in the light of the expanding range of approaches which can extract important information from noisy observations.
Tax evasion and government size: evidence from Italian provinces
Authors: D’Agostino Elena , De Benedetto Marco Alberto , Sobbrio Giuseppe 
Published: April 2021

AbstractWe analyze the impact of government size, measured by total spending per capita, on tax evasion at the provincial level in Italy over the period 2001–2015. In order to solve endogeneity issues we rely on a system GMM and find that public expenditure negatively affects tax evasion, as taxpayers perceive the government is efficiently spending resources coming from the tax levy. Results are confirmed when we (1) consider expenditures related to long-term investments, namely capital spending per capita, and (2) directly test the impact of government efficiency on tax evasion. In addition, we show that the impact of public spending is heterogeneous across geographical areas: an increase in public expenditure leads to a downward shift in tax evasion only in the northern part of Italy, characterized by a relatively larger initial level of public goods provision.
Seismic rocking effects on a mine tower under induced and natural earthquakes
Authors: Bońkowski Piotr Adam , Kuś Juliusz , Zembaty Zbigniew 
Published: April 2021

Abstract
Recent research in engineering seismology demonstrated that in addition to three translational seismic excitations along x, y and z axes, one should also consider rotational components about these axes when calculating design seismic loads for structures. The objective of this paper is to present the results of a seismic response numerical analysis of a mine tower (also called in the literature a headframe or a pit frame). These structures are used in deep mining on the ground surface to hoist output (e.g. copper ore or coal). The mine towers belong to the tall, slender structures, for which rocking excitations may be important. In the numerical example, a typical steel headframe 64 m high is analysed under two records of simultaneous rocking and horizontal seismic action of an induced mine shock and a natural earthquake. As a result, a complicated interaction of rocking seismic effects with horizontal excitations is observed. The contribution of the rocking component may sometimes reduce the overall seismic response, but in most cases, it substantially increases the seismic response of the analysed headframe. It is concluded that in the analysed case of the 64 m mining tower, the seismic response, including the rocking ground motion effects, may increase up to 31% (for natural earthquake ground motion) or even up to 135% (for mining-induced, rockburst seismic effects). This means that not only in the case of the design of very tall buildings or industrial chimneys but also for specific yet very common structures like mine towers, including the rotational seismic effects may play an important role.
Evolution of the Oceanic 13C Suess Effect in the Southeastern Indian Ocean Between 1994 and 2018
Authors: Williams Thomas J. , Wagner Amy J. , Sikes Elisabeth L. , Martin Ellen E. 
Published: April 2021

AbstractThe decrease in δ13C of dissolved inorganic carbon (δ13CDIC) owing to uptake of anthropogenic CO2 (the oceanic 13C Suess effect) in the Southeastern Indian Ocean over the last decade was calculated using an extended multiparameter linear regression technique. Samples collected on the CROCCA‐2S (Coring to Reconstruct Ocean Circulation and Carbon Dioxide Across 2 Seas) cruise in November–December 2018 were compared to samples from the CLIVAR (Climate and Ocean: Variability, Predictability, and Change) and OISO (Océan Indien Service d'Observation) programs from 2007 to 2009. Surface ocean δ13CDIC decreased by an average of −0.53 ± 0.04‰ across this period, at an average rate of −0.053 ± 0.004‰ per year. This rate of δ13CDIC change is an increase from −0.021 ± 0.024‰ per year between 1994 and 2008. We find that the interior water mass most impacted by the oceanic 13C Suess effect between 2008 and 2018 was Subantarctic Mode Water (SAMW), within which δ13CDIC decreased by −0.044 ± 0.002‰ per year. Using previously published relationships between the oceanic 13C Suess effect and anthropogenic carbon, we estimate the annual storage of anthropogenic carbon within SAMW in the southeastern Indian Ocean has increased from ∼2.0 ± 0.2 μmol/kg per year between 1994 and 2008 to 5.5 ± 0.6 μmol/kg per year between 2008 and 2018.
Refining Higher Modes of Rayleigh Waves Using Seismoelectric Signals Excited by a Weight‐Drop Source: Study From Numerical Simulation Aspect
Authors: Yuan Shichuan , Ren Hengxin , Huang Qinghua , Zheng Xu‐Zhen , Yang Zhentao , He Zhanxiang , Zhang Wei , Chen Xiaofei 
Published: April 2021

AbstractEffective extraction of higher mode dispersion information has been a research hotspot in the study of surface waves. In this study, we introduce a novel approach of refining Rayleigh wave higher modes by using seismoelectric signals, namely, electromagnetic (EM) signals originating from seismoelectric conversion. Adopting a weight‐drop source, we simulate seismic and EM signals for several porous models. An extended version of the frequency‐Bessel transform method is introduced to extract dispersion information from seismic and EM signals. Results suggest that the evanescent seismoelectric waves, which are induced at subsurface interfaces penetrated by Rayleigh waves and finally are recorded nearby the ground surface after undergoing amplitude decay, can reflect dispersion characteristics of Rayleigh waves and can provide extra higher‐mode dispersion information that seismic waves cannot. We find the vadose zone with higher water saturation will cause the seismoelectric signals to have stronger strengths and change their frequency coverage of dispersion information. Electric fields obtained from potential differences between longer dipole electrodes suffer more severe distortion. In an electrically resistive environment, predicted seismoelectric signal amplitudes in the frequency band with dominant energy are well above expected background noise levels. We also find seismoelectric signals have a stronger antialiasing ability than seismic waves and their dispersion energy values are sensitive to salinity and fluid viscosity. Generally speaking, our study suggests Rayleigh wave dispersion information with abundant higher modes and good frequency‐range coverage can be obtained by using seismic and seismoelectric signals together due to their complementarity.
Study on the 1906 Colombia‐Ecuador Megathrust Earthquake Based on Tsunami Waveforms Observed at Tide Gauges: Release Variation of Accumulated Slip Deficits in the Source Area
Authors: Yamanaka Yusuke , Tanioka Yuichiro 
Published: April 2021

AbstractA tsunami that followed the 1906 Colombia‐Ecuador megathrust earthquake was observed and recorded by several tide gauges. In this study, tide gauge records were first digitized from documents comparing the estimated astronomical tide level changes, and the observed tsunami waveforms were extracted. An inverse analysis was conducted using the observed tsunami waveforms, and we successfully developed a slip distribution model that produced improved tsunami waveforms for tide gauge stations compared with previous studies. Based on a comparison of the developed source model and ruptured areas of other significant earthquakes around Colombia and Ecuador, the 1906 earthquake already ruptured an area affected by the 1979 earthquake, resulting in a substantial release of accumulated slip deficits. In contrast, although the ruptured area of the 1906 earthquake likely covered the source areas of the 1958 and 1942 earthquakes, the release in these areas during the earthquake was moderate and insignificant, and large slip deficits remained after the 1906 earthquake. These results demonstrate that the extent of the release of accumulated slip deficits varied greatly in the source area of the 1906 earthquake.
Multi‐Year Estimates of Daily Heat Transport by the Atlantic Meridional Overturning Circulation at 34.5°S
Authors: Kersalé M. , Meinen C. S. , Perez R. C. , Piola A. R. , Speich S. , Campos E. J. D. , Garzoli S. L. , Ansorge I. , Volkov D. L. , Le Hénaff M. , Dong S. , Lamont T. , Sato O. T. , van den Berg M. 
Published: April 2021

AbstractVariations in the mass and heat transported by the meridional overturning circulation (MOC) have important, well‐documented, influences on global and regional climate, weather, ecosystems, and coastal sea levels. However, continuous, high‐frequency, observations of these quantities have been limited to date. Multiple years of full‐depth daily observations from moored instruments in the South Atlantic at 34.5°S are combined with satellite observations to resolve the volume transports in both the upper and abyssal MOC cells, and the associated full‐depth meridional heat transport (MHT), on daily to interannual timescales. A newly developed method for combining satellite sea level observations with historical hydrographic measurements was used to estimate daily full‐depth ocean profiles of temperature in the ocean interior where mooring coverage is sparse. The average MHT during 2013–2017 is 0.5 PW, with a daily standard deviation of 0.8 PW. The MHT variability is most strongly driven by the geostrophic relative velocity contributions (horizontal density‐gradient changes). This variability is highly correlated with the volume transport variability of the MOC upper cell (r = 0.96) and modestly anti‐correlated (r = −0.52) with the abyssal cell variations. An empirical relationship between the MHT and MOC values was developed allowing the reconstruction of a longer MHT time series including the pilot array period (2009–2010). Seasonal variation of the MHT is significant, and results from strong variations of all terms (Ekman, barotropic, and baroclinic). Although the 2013–2017 shows an increasing MHT trend (0.14 PW/year), the longer time period record suggests that the apparent trend may simply be interannual modulation of MHT at 34.5°S.