bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological, osteological, and genetic data support a new species of Madatyphlops (Serpentes: Typhlopidae) endemic to Mayotte Island, Comoros Archipelago
Authors: Hawlitschek Oliver , Scherz Mark D. , Webster Kathleen C. , Ineich Ivan , Glaw Frank 
Published: February 2021

AbstractBlind snakes (Typhlopidae) are an enigmatic group of small burrowing snakes whose anatomy, phylogenetics, and biodiversity remain poorly known. Madatyphlops comorensis (Boulenger, 1889), endemic to the Comoros Archipelago in the Western Indian Ocean, is one of many species whose phylogenetic placement and generic assignment is unclear. We used DNA barcoding, external morphological examination, and osteological data from 3D reconstruction with micro‐CT to study specimens of Madatyphlops from the Comoros Archipelago. Our results support the placement of M. comorensis in Madatyphlops and the recognition of the specimens from Mayotte Island as a closely related but distinct species, which we describe as Madatyphlops eudelini sp. nov. In this context, we present the first detailed osteological descriptions of any species of Madatyphlops, which we hope will serve as groundwork for further osteological studies in this genus and contribute to our limited but growing understanding of the osteology of typhlopid snakes.
(+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents
Authors: Sokolova Anastasiya S. , Kovaleva Kseniya S. , Yarovaya Olga I. , Bormotov Nikolay I. , Shishkina Larisa N. , Serova Olga A. , Sergeev Alexander A. , Agafonov Alexander P. , Maksuytov Rinat A. , Salakhutdinov Nariman F. 
Published: February 2021

AbstractAlthough the World Health Organisation had announced that smallpox was eradicated over 40 years ago, the disease and other related pathogenic poxviruses such as monkeypox remain potential bioterrorist weapons and could also re‐emerge as natural infections. We have previously reported (+)‐camphor and (−)‐borneol derivatives with an antiviral activity against the vaccinia virus. This virus is similar to the variola virus (VARV), the causative agent of smallpox, but can be studied at BSL‐2 facilities. In the present study, we evaluated the antiviral activity of the most potent compounds against VARV, cowpox virus, and ectromelia virus (ECTV). Among the compounds tested, 4‐bromo‐Nʹ‐((1R,4R)‐1,7,7‐trimethylbicyclo[2.2.1]heptan‐2‐ylidene)benzohydrazide 18 is the most effective compound against various orthopoxviruses, including VARV, with an EC50 value of 13.9 μM and a selectivity index of 206. Also, (+)‐camphor thiosemicarbazone 9 was found to be active against VARV and ECTV.
Bioeconomy and biofuels: the case of sugarcane ethanol in Brazil
Authors: Karp Susan G , Medina Jesus D C , Letti Luiz A J , Woiciechowski Adenise L , de Carvalho Júlio C , Schmitt Caroline C , de Oliveira Penha Rafaela , Kumlehn Gabriel S , Soccol Carlos R 
Published: February 2021

AbstractBrazilian bioethanol is one of the most prominent biofuels produced on a large scale, representing 30% of the global fuel ethanol production share. Around 8.6 billion gallons were produced in 2019, second only to the US fuel ethanol production in the same period (15.8 billion gallons). Obtained from sugarcane in a highly energy‐efficient process, the biofuel, which can be used in Brazil as 100% ethanol (hydrated, minimum mass content of 92.5%) or in a volume proportion of 27% (anhydrous ethanol) in common gasoline, has contributed to the reduction of oil dependency and CO2 emissions, as well as to the development of an important economic sector. Pioneer biofuel policies and important advances in science and technology led to the establishment of a 46% renewable energy matrix. In this manuscript, an overview of the impacts of ethanol production and utilization will be given, with respect to environmental and socio‐economic concerns. The public policies and some technical aspects of sugarcane and ethanol production and energy cogeneration will be reviewed and discussed. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Near‐term practical strategies to improve the life cycle techno‐economics, energy use and greenhouse gas emissions of corn stover supply system for biobased industries
Authors: Shah Ajay , Manandhar Ashish , Darr Matthew J. 
Published: February 2021

AbstractCorn stover is predominantly used as the feedstock in the cellulosic biorefineries of the Midwestern USA; however, there are several opportunities to improve the performance of its supply chain. Thus, there is a need to optimize the corn stover supply system for the overall sustainability of the corn stover‐based industries. This paper presents three practical strategies that could be implemented in the near term to improve the performance of the corn stover supply chain. The first strategy involves reducing the corn stover collection area, which entails improving producers’ participation through enhanced knowledge transfer related to this industry, improving harvest ratio of biomass, and reducing dry matter loss during biomass handling and storage. The second strategy involves reducing the overall bale supply quantity, which primarily entails increasing bale density. The final suggested strategy involves reducing quantities of in‐field machinery, which is possible through improving the efficiency of field machinery, including windrowers, balers, and stackers, and increasing their harvest durations. By successfully implementing these strategies, the overall cost associated with the supply of corn stover, energy use, and greenhouse gas emissions could be reduced, on an average, by 34–35% from the current average benchmarks of $95.9/metric ton (t), 11% and greenhouse gas emissions is 58.4 kg CO2e/t, respectively. This can contribute toward creating a cost‐effective logistics system that is also environmentally sustainable. This will be critical for the long‐term success of the biorefineries using corn stover as the primary feedstock. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Abnormal brain functional networks in end‐stage renal disease patients with cognitive impairment
Authors: Yue Zheng , Wang Pengming , Li Xuekun , Ren Jipeng , Wu Baolin 
Published: February 2021

AbstractIntroductionCognitive impairment (CI) is common in patients with end‐stage renal disease (ESRD). Neuroimaging studies have demonstrated structural and functional brain alterations underlying CI in patients with ESRD. However, the patterns of change in whole‐brain functional networks in ESRD patients with CI remain poorly understood.MethodsWe enrolled 66 patients with ESRD (36 patients with CI and 30 patients without CI) and 48 healthy control subjects (HCs). We calculated the topological properties using a graph theoretical analysis. An analysis of covariance (ANCOVA) was used to compare network metrics among the three groups. Moreover, we analyzed the relationships between altered network measures and clinical variables in ESRD patients with CI.ResultsCompared with HCs, both patient groups showed lower local efficiency and small‐worldness. ESRD patients had decreased nodal centralities in the default mode regions and right amygdala. Comparison of the two patient groups showed significantly decreased global (small‐worldness) and nodal (nodal centralities in the default mode regions) properties in the CI group. Altered nodal centralities in the bilateral medial part of the superior frontal gyrus, left posterior cingulate gyrus, and right precuneus were associated with cognitive performance in the CI group.ConclusionDisrupted brain functional networks were demonstrated in patients with ESRD, which were more severe in those with CI. Moreover, impaired nodal centralities in the default mode regions might underlie CI in patients with ESRD.
Circular business model evolution: Stakeholder matters for a self‐sufficient ecosystem
Authors: Moggi Sara , Dameri Renata Paola 
Published: February 2021

AbstractFood waste is a key issue in the circular economy. A circular ecosystem results from the contributions of various stakeholders; however, the claims and value propositions of these stakeholders can differ, hampering long‐term sustainability of the ecosystem. This study analyses the case of RiCibo, a circular ecosystem based in Genoa, Italy. RiCibo collects surplus food and redistributes it to the needy in the local community. The study examines the conditions that facilitated RiCibo’s evolution from a simple project to a circular self‐sufficient ecosystem characterised by a co‐designed circular business model with a broad range of stakeholders. The results show that sharing people, infrastructure and knowledge, together with mutual trust among stakeholders, are the preconditions of a circular ecosystem. Long‐term continuity depends on additional tools that enhance financial self‐sufficiency, namely, participative governance, a co‐designed circular business model, accountability, frequent engagement, local actions and the development of advocacy power.
Involvement of long non‐coding RNAs in the progression of esophageal cancer
Authors: Xue Wenhua , Zheng Yuanyuan , Shen Zhibo , Li Lifeng , Fan Zhirui , Wang Wenbin , Zhu Zijia , Zhai Yunkai , Zhao Jie , Kan Quancheng 
Published: February 2021

AbstractEsophageal cancer (EC) is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide. Therefore, exploring the pathogenesis of EC and searching for new targeted therapies are the current research hotspot for EC treatment. Long non‐coding RNAs (lncRNAs) are endogenous RNAs with more than 200 nucleotides, but without protein‐coding function. In recent years, lncRNAs have gradually become the focuses in the field of non‐coding RNA. Some lncRNAs have been proved to be closely related to the pathogenesis of EC. Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation, apoptosis, and metastasis by inhibiting or promoting target gene expression. LncRNAs can also regulate the progression of EC through epithelial‐mesenchymal transformation (EMT), which is closely related to the occurrence, development, and prognosis of EC. In this article, we review and discuss the involvement of lncRNAs in the progression of EC.
Low‐grade chronic inflammation and immune alterations in childhood and adolescent cancer survivors: A contribution to accelerated aging?
Authors: Sulicka‐Grodzicka Joanna , Surdacki Andrzej , Seweryn Michał , Mikołajczyk Tomasz , Rewiuk Krzysztof , Guzik Tomasz , Grodzicki Tomasz 
Published: February 2021

AbstractBackgroundThe long‐term consequences of chemotherapy and radiotherapy result in a high prevalence and early onset of age‐related chronic diseases in survivors. We aimed to examine whether childhood and adolescent cancer survivors (CS) demonstrate biomarkers of accelerated aging.MethodsWe evaluated 50 young adult CS at 11 [8–15] years after cancer diagnosis, and 30 healthy, age and sex‐matched controls, who were unexposed to cancer therapy. Using a machine‐learning approach, we assessed factors discriminating CS from controls and compared selected biomarkers and lymphocyte subpopulations with data from the Framingham Heart Study (FHS) cohort and the Genotype Tissue Expression (GTEx) project.ResultsSurvivors compared with controls had higher levels of C‐reactive protein and fibrinogen. The surface expression of CD38 on T cells was increased, and there was an increase in the percentage of memory T cells in survivors, compared with the unexposed group. The relationships between above cell subpopulations and age were consistent in CS, FHS, and GTEx cohorts, but not in controls.ConclusionsYoung pediatric cancer survivors differ from age‐related controls in terms of activation of the adaptive immune system and chronic, low‐grade inflammation. These changes resemble aging phenotype observed in older population. Further research in biomarkers of aging in young, adult childhood cancer survivors is warranted, as it may facilitate screening and prevention of comorbidities in this population.
Diagnostic value of sialyl‐Tn immunocytochemistry in breast cancer presenting with pathological nipple discharge
Authors: Xu Feng , Gao Yue , Diao Xiaoli , Li Jie , Jiang Hongchuan , Zhao Hongying 
Published: February 2021

AbstractBackgroundMucin‐associated sialyl‐Tn (sTn) antigen is overexpressed and related with adverse outcome in breast cancer (BC). The role of sTn in BC has not been well defined in pathological nipple discharge (PND) cytology. The authors examined sTn immunocytochemistry (ICC) in PND to determine whether it could be a biomarker of malignancy or aggressive disease.MethodsPND was subjected to immunocytochemical staining for sTn antigen expression and thinprep cytology test (TCT) for enhancing the sensitivity and specificity. The examination data was compared with histological findings of subsequent biopsy specimens. Logistic regression analysis was used to determine which factors were most associated with malignant breast lesions.ResultsPND specimens were collected including 120 cases of intraductal papilloma, 24 cases of hyperplasia, 45 cases of ductal carcinoma in situ (DCIS), and 48 cases of invasive ductal carcinoma (IDC). STn ICC differentiated BC from benign intraductal lesions with a low sensitivity of 41.9% and a high specificity of 95.8%, but increased in combination with TCT to 64.5% and 100%, respectively. A high degree of concordance was observed between the results of sTn expression in cell smears and histological specimens. Moreover, the sTn expression was strongly associated with HER2‐positive IDC (p = 0.039). Multivariate logistic analysis showed that positive sTn expression (OR: 14.241, 95%CI: 2.574, 78.794, p = 0.010) and accompanying mass (OR: 3.307, 95%CI: 1.073, 10.188, p = 0.037) were statistically significant independent risk factors for malignant PND.ConclusionsMucin‐associated sTn expression in PND cytology appears to be a reliable diagnostic marker for BC patients with the chief complaint of malignant nipple discharge and indicates a more aggressive behavior in IDC.
Monolingual therapists’ views and experiences of working with multilingual clients: An exploratory study
Authors: Carmen Calvo‐Rodríguez M. 
Published: February 2021

AbstractAlthough much attention has been paid in recent years to culture and diversity, cross‐lingual issues in the counselling room have not been given the consideration they deserve. This field is under‐researched in the UK, particularly from the monolingual counsellor's perspective, and often focuses on working with interpreters or addressing communication barriers. This brief study sets out to explore the experiences of monolingual therapists in the UK when working with proficient multilingual clients, trying to find out whether interventions such as ‘language switching’ are used therapeutically by monolinguals, and what their views are regarding supervision and training. A qualitative approach was taken, with a semi‐structured questionnaire collecting data from 50 participants. Thematic analysis was used to interpret their answers. The findings revealed that the majority of monolingual therapists had not reflected on the psychological and socio‐political implications of using English exclusively, the diverse roles of language and the specific needs of multilingual clients. The highest awareness was found among the most experienced counsellors, who perceived working with multilingual clients as an opportunity for personal and professional development and who showed as much linguistic empathy as multilingual counsellors. However, most participants placed a strong emphasis on communication barriers, which may indicate that, as counsellors, we could be overlooking the opportunities that cross‐lingual exchanges present therapeutically and, as a result, we may be failing to address the needs of multilinguals in our diverse community. The study concluded that there is a need to include this topic in counselling training and do further research.
The complex triad of congruence issues in influencer marketing
Authors: von Mettenheim Walter , Wiedmann Klaus‐Peter 
Published: February 2021

AbstractFinding a fitting endorser has proven to be one of the most delicate and critical tasks of influencer marketing. This research explores the relevance of the congruency of the influencer personality with (1) brand personality and consumers' (2) actual/(3) ideal selves. Additionally, the (4) moderating role of involvement is considered, the impacts on post attitude/belief, brand trust and purchase intention are thereby studied. The novelty of this study lies in the integral examination of the types of congruencies and involvement in the context of influencer marketing as well as the consideration of their impact on the brand‐related variables. Based on an online survey with 547 participants analyzed by means of structural equation modeling in SmartPLS, partly counterintuitive findings were produced. When the involvement level rises, congruence with consumers' actual selves becomes more important. Under low‐involvement conditions, practitioners should pay more attention to influencers' fit with consumers' ideal selves. An adequate fit between brand and endorser is paramount and becomes even more important under high‐involvement conditions. Overall, this study reveals that the three types of congruency and involvement interact in a very unique way in the context of influencer marketing.
Complete response to larotrectinib treatment in a patient with papillary thyroid cancer harboring an ETV6‐NTRK3 gene fusion
Authors: Pitoia Fabián 
Published: February 2021

AbstractLarotrectinib, a highly selective TRK inhibitor, was administered to a patient with rapidly progressing radioactive iodine‐refractory papillary NTRK3 fusion‐positive thyroid cancer. The patient achieved a durable (sustained for 11 months) complete response after 2 months of treatment and complete intracranial responses in metastatic brain lesions after 7 months of treatment.Larotrectinib may provide a therapeutic route for patients with RAI‐R‐differentiated thyroid cancer who might otherwise have few treatment options.
Favism‐induced methemoglobinemia in a G6PD deficient male with a subsequent hemolytic cascade, a therapeutic challenge: Case report and review of literature
Authors: Ata Fateen , Javed Saad , Muthanna Bassam , dakhlia Ines , Bint I Bilal Ammara , Musa Motwakil , Uddin Mashuk , Yassin Mohamed A. 
Published: February 2021

AbstractThe co‐occurrence of acute hemolysis and methemoglobinemia secondary to favism in G6PD deficient individuals is rare. Identifying it promptly is of high clinical significance as treating methemoglobinemia (with methylene blue) can worsen hemolysis.
Fluorescent light energy combined with systemic isotretinoin: A 52‐week follow‐up evaluating efficacy and safety in treatment of moderate‐severe acne
Authors: Russo Antonio , Mellergaard Maiken , Pellacani Giovanni , Nisticò Steven , Nielsen Michael Canova Engelbrecht 
Published: February 2021

AbstractFluorescent light energy therapy combined with low‐dose isotretinoin or tetracycline show remarkable clinical effect on 12 cases of moderate‐to‐severe acne. Treatment was considered safe, well‐tolerated, and highly efficacious.
Anti‐Programmed death‐1 therapy in advanced hepatocellular carcinoma: A real‐world experience
Authors: Al jarroudi Ouissam , Chaabouni Hamed , Ulusakarya Ayhan , Almohamad Wathek , Gumus Yusuf , Goldschmidt Emma , Afqir Said , Morère Jean‐francois 
Published: February 2021

AbstractNivolumab is an effective and safe treatment in HCC.
Unexpected foreign body induced refractory maxillary sinusitis
Authors: Hallak Bassel , Teiga Pedro , Bühler Jean‐Pierre , Bouayed Salim 
Published: February 2021

AbstractMaxillary sinusitis induced by ipsilateral dental manipulation often carries the risk of sinusal foreign body impaction. Adequate evaluation mandates radiological exploration of the sinus. Management requires complete foreign body removal, surgical drainage of the sinus, and closure of any oroantral communication or fistula.
Manipulating metal–sulfur interactions for achieving high‐performance S cathodes for room temperature Li/Na–sulfur batteries
Authors: Dai Ying‐Ying , Xu Chun‐Mei , Liu Xiao‐Hao , He Xiang‐Xi , Yang Zhuo , Lai Wei‐Hong , Li Li , Qiao Yun , Chou Shu‐Lei 
Published: February 2021

AbstractRechargeable lithium/sodium–sulfur batteries working at room temperature (RT‐Li/S, RT‐Na/S) appear to be a promising energy storage system in terms of high theoretical energy density, low cost, and abundant resources in nature. They are, thus, considered as highly attractive candidates for future application in energy storage devices. Nevertheless, the solubility of sulfur species, sluggish kinetics of lithium/sodium sulfide compounds, and high reactivity of metallic anodes render these cells unstable. As a consequence, metal–sulfur batteries present low reversible capacity and quick capacity loss, which hinder their practical application. Investigations to address these issues regarding S cathodes are critical to the increase of their performance and our fundamental understanding of RT‐Li/S and RT‐Na/S battery systems. Metal–sulfur interactions, recently, have attracted considerable attention, and there have been new insights on pathways to high‐performance RT‐Li/Na sulfur batteries, due to the following factors: (1) deliberate construction of metal–sulfur interactions can enable a leap in capacity; (2) metal–sulfur interactions can confine S species, as well as sodium sulfide compounds, to stop shuttle effects; (3) traces of metal species can help to encapsulate a high loading mass of sulfur with high‐cost efficiency; and (4) metal components make electrodes more conductive. In this review, we highlight the latest progress in sulfide immobilization via constructing metal bonding between various metals and S cathodes. Also, we summarize the storage mechanisms of Li/Na as well as the metal–sulfur interaction mechanisms. Furthermore, the current challenges and future remedies in terms of intact confinement and optimization of the electrochemical performance of RT‐Li/Na sulfur systems are discussed in this review.
Extraction and concentration of glutathione from yeast by membranes
Authors: Wang Yiran , Xiao Tonghu , Zhang Zhigen , Feng Xianshe 
Published: February 2021

AbstractThis study dealt with extraction of glutathione from yeast using hot water, followed by membrane separations. The supernatant of the yeast extract was subjected to ultrafiltration (UF) to remove macromolecules, and the glutathione in the resulting ultrafiltrate was concentrated using a nanofiltration (NF) membrane. The relationships between the permeation flux and volume concentration ratio (VCR) were investigated, and the resistance of the membrane fouling layer was analyzed. This study also investigated the effects of hot water extraction conditions (e.g., temperature and time) on the glutathione yield, as well as the stability of glutathione when exposed to light. The research findings suggest that the integrated UF and NF process is a promising approach to concentrating and purifying glutathione from yeast extract.