bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats
Authors: Zhao Lijuan , Han Lingyu , Wei Xiaolu , Zhou Yanyan , Zhang Yanqiong , Si Nan , Wang Hongjie , Yang Jian , Bian Baolin , Zhao Haiyu 
Published: December 2021

Arenobufagin (ArBu), one of the main active bufadienolides of toad venom with cardiotonic effect, analgesic effect, and outstanding anti-tumor potentiality, is also a potential cardiotoxic component. In the present study, the cardiac effect of ArBu and its underlying mechanism were explored by integrating data such as heart rates, toxicokinetics, myocardial enzyme and brain natriuretic peptide (BNP) activity, pathological sections, lipidomics and proteomics. Under different doses, the cardiac effects turned out to be different. The oral dose of 60 mg/kg of ArBu sped up the heart rate. However, 120 mg/kg ArBu mainly reduced the heart rate. Over time, they all returned to normal, consisting of the trend of ArBu concentration-time curve. High concentrations of myocardial enzymes and BNP indicated that ArBu inhibited or impaired the cardiac function of rats. Pathological sections of hearts also showed that ArBu caused myocardial fiber disorder and rupture, in which the high-dose group was more serious. At the same time, serum and heart tissue lipidomics were used to explore the changes in body lipid metabolism under different doses. The data indicated a larger difference in the high-dose ArBu group. There were likewise many significant differences in the proteomics of the heart. Furthermore, a multi-layered network was used to integrate the above information to explore the potential mechanism. Finally, 4 proteins that were shown to be significantly and differentially expressed were validated by targeted proteomics using parallel reaction monitoring (PRM) analysis. Our findings indicated that ArBu behaved as a bidirectional regulation of the heart. The potential mechanism of cardiac action was revealed with the increased dose, which provided a useful reference for the safety of clinical application of ArBu.
Effects of Drilling Technology on Mini-Implant Primary Stability: A Comparison of the Mechanical Drilling and Femtosecond Laser Ablation
Authors: Zhang Wenbin , Alghannam Fahad , Zhu Yingchao , Zhang Jianfei , Wohl Gregory R , Haugen Harold K. , Qin Zhipeng , Xie Guoqiang , Fang Qiyin , Shen Steve Guofang 
Published: December 2021

Objectives: Primary stability is a fundamental prerequisite in predicting the prognosis of a mini-implant (MI) as a skeletal anchorage. This study aims to evaluate the influence of implant site preparation technology on the primary stability of MI.Methods: A total of 108 bovine cortical bone samples were fabricated to three thicknesses (0.5, 1.0, and 1.5 mm). For each thickness group, the samples were divided into three subgroups: I (without site preparation), II (site preparation with a mechanical drill), and III (site preparation with femtosecond laser ablation). After MI insertion into these samples, the pull out strength of MI was measured by lateral pull out tests.Results: For the 0.5 mm thickness samples, the lateral pull-out strength was 9.9±2.7 N in subgroup I, 6.7±2.1 N in subgroup II, and 15.2±2.6 N in subgroup III. For the 1.0 mm thickness samples, the lateral pull-out strength was 39.3±2.5N in subgroup I, 38.2±2.7N in subgroup II, and 46.3±1.7 N in subgroup III. For the 1.5 mm thickness samples, the lateral pull-out strength was 73.9±4.8 N in subgroup I, 70.1±2.8 N in subgroup II, 75.0±2.2 N in subgroup III. No signs of carbonization or substantial cracking were visible in any of the bone samples.Conclusion: Site preparation with laser ablation significantly improved the lateral pull-out strength over mechanical preparation and control (no site preparation) in thinner cortical bone samples (1.0 and 0.5 mm). Such improvement in lateral pull-out strength decreases as the samples become thicker and diminishes in thick (1.5 mm) cortical bone samples.
Assessment of Impact of Containment During the COVID-19 Epidemic and Coping Behaviours Using Newly Developed Assessment Tools
Authors: Wong Li Ping , Alias Haridah , Danaee Mahmoud , Lee Hai Yen , Tan Kit Mun , Tok Peter Seah Keng , Muslimin Mustakiza , AbuBakar Sazaly , Lin Yulan , Hu Zhijian 
Published: December 2021

Background: The confinement measures during COVID-19 had a massive effect on physical and psychological health in public. This study assessed the impact of containment and coping behaviour among the Malaysia public during the COVID-19 pandemic. Questions assessing the impact of containment and coping behaviours were developed and psychometrically tested.Methods: Exploratory factor analysis (EFA) was conducted with the items using principal component analysis extraction and Varimax rotation. Partial least squares structural equation modelling was used to determine the relationship between coping and impact.Results: The 13-item of impact and 10-item coping instruments were developed with three dimensions identified through EFA. Both scales demonstrated excellent composite reliability and good convergent validity. The survey findings revealed that the impact on individual psychological aspects was prominent, followed by well-being and lifestyle. Mindfulness and physical coping strategies were most commonly reported. Coping through seeking help from health professionals and hotlines had a positive direct effect on well-being and lifestyle (b = 0.231, p &lt; 0.001), psychological (B = 0.132, p &lt; 0.001), and employment-related (0.194, p &lt; 0.001) impacts. Coping through mindfulness practise had a negative effect on well-being and lifestyle-related impact (B = −0.180, p &lt; 0.001) and employment-related impact (B = −0.096, p = 0.008).Conclusions: Despite some limitation, the scales for measuring impact and coping behaviours have the potential to be used as a measurement tool in future studies. Findings highlight the enormous impact of the pandemic on psychological well-being and lifestyles. Health authorities should support individual coping as it was found to be an important resilience-related factor to mitigate the impacts of containment during the pandemic.
Management of Nephrolithiasis in Pregnancy: Multi-Disciplinary Guidelines From an Academic Medical Center
Authors: Lee Matthew S. , Fenstermaker Michael A. , Naoum Emily E. , Chong Suzanne , Van de Ven Cosmas J. , Bauer Melissa E. , Kountanis Joanna A. , Ellis James H. , Shields James , Ambani Sapan , Krambeck Amy E. , Roberts William W. , Ghani Khurshid R. 
Published: December 2021

Introduction: The management of nephrolithiasis during pregnancy can be stressful for urologists due to concerns for investigations and treatments that may pose risk of fetal harm, and unfamiliarity with optimal management of these complex patients. In response, we created multi-disciplinary evidence-based guidelines to standardize the care for obstetric patients presenting with flank pain and suspicion for nephrolithiasis.Methods: A multi-disciplinary team involving Urology, Obstetric Anesthesiology, Obstetrics and Gynecology, Diagnostic Radiology, and Interventional Radiology from a single academic medical center was assembled. A PubMed search was performed using keywords of pregnancy/antepartum, nephrolithiasis/calculi/kidney stones, ureteroscopy, non-obstetric surgery, complications, preterm delivery, MRI, computerized tomography, renal bladder ultrasound (RBUS), and anesthesia to identify relevant articles. Team members reviewed their respective areas to create a comprehensive set of guidelines. One invited external expert reviewed the guidelines for validation purposes.Results: A total of 54 articles were reviewed for evidence synthesis. Four guideline statements were constructed to guide diagnosis and imaging, and seven statements to guide intervention. Guidelines were then used to create a diagnostic and intervention flowchart for ease of use. In summary, RBUS should be the initial diagnostic study. If diagnostic uncertainty still exists, a non-contrast CT scan should be obtained. For obstetric patients presenting with a septic obstructing stone, urgent decompression should be achieved. We recommend ureteral stent placement as the preferred intervention if local factors allow.Conclusions: We present a standardized care pathway for the management of nephrolithiasis during pregnancy. Our aim is to standardize and simplify the clinical management of these complex scenarios for urologists.
FEATURES OF SOCIAL AND PSYCHOLOGICAL ACTIVITY OF SPORTS COACH
Authors: KORNOSENKO O. , DEMUS Ya. 
Published: December 2021

The basis of sports are interconnected activities: training, coaching, competitions. Achieving success in sports requires a high level of formation not only of physical qualities and motor skills, but also psychological readiness for training and competitiveloads. The inability to control one’s emotions can nullify years of training. The coach and the sports psychologist are key figures in preparing the athlete for the main starts. Their main professional responsibilities include: timely study of individual characteristics of the athlete’s psyche, development of an individual plan for the development of abilities, strategies of pre-competitive and competitive behavior, formation of necessary mental qualities to win, creating psychologically comfortable conditions in sports, identifying ways to overcome emotional burnout in crisis periods that are caused by various reasons: defeat in the competition, transfer to another team, change of coach, problems in personal life, etc. The tandem “athlete-coach” in the context of psychological interaction and mutual understanding is a basic lever in the education of personal qualities and achieving high sports results.In the context of our study, we distinguish a number of professional functions of a modern coach - educational, managerial, regulatory, formative, gnostic, socio-psychological. The main function that allows to exercise psychological influence and control over the condition of the athlete at different stages of sports training is socio-psychological. This function, on the one hand, requires the coach to be able to establish contact with students, clearly, accurately and clearly explain the requirements for athletes, and on the other - to provide psychological support, create a psychologically comfortable microclimate in the sports team and more.A detailed analysis of the socio-psychological function of the coach suggests that the coach must have a number of theoretical knowledge, professional and practical skills, language, public speaking, communication skills, ability to make managerial decisions, experience of their own sports, have a high level of empathy, stress, etc., the symbiosis of which allows him to have ahigh level of leadership, authority, competence.
Análisis Business Observation Tool de la sostenibilidad portuaria. Aplicación al sistema portuario español
Authors: Serrano Beatriz Molina , González-Cancelas Nicoleta , Soler Flores Francisco , Santos-Martín Ana Eladia 
Published: December 2021

Cada día el mundo actual avanza, gracias a las numerosas investigaciones, el desarrollo de tecnologías, la aparición de las plataformas digitales y multitud de iniciativas de crecimiento. Actualmente todo está enfocado a proteger el medio ambiente y los recursos disponibles, haciendo un uso eficiente e inteligente de ellos para que no solo para que la sociedad actual disfrute de ello, sino también las generaciones futuras, tal y como dictamina el concepto de desarrollo sostenible. Trasladado a los puertos, espacios destinados al flujo de mercancías, personas e información y abrigo de las naves, todas las actividades allí efectuadas han de velar y proteger su compromiso con la sostenibilidad. Por lo que se propone aquí un análisis minucioso de la sostenibilidad del sistema portuario español a través de una herramienta gráfica y pionera en el ámbito portuario como es el Business Observation Tool. Herramienta dedicada a dar inicio y reconocer elementos mínimos a considerar al formular una idea sobre la sostenibilidad portuaria, permitiendo conocer la realidad de las condiciones del entorno portuario y establecer los escenarios posibles para evolucionar más allá de la realidad observada.
Destiny in Nālaṭiyār and Tirukkuṟal – A Comparative Study
Authors: R Premkumar 
Published: December 2021

Influence of idea of destiny in Tamil society could be traced back to sangam period. It is regarded that eighteen lesser works (patiṇ̱eṇkḹḻkkaṇakkunūlkal) emerged in the post- sangam period in which Jainism and Buddhism had abundant influenced in life and literature of Tamils. This period is also conceived the period of righteousness (aṟaneṟikkālam) by scholars of Tamil Literature. Tirukkuṟal and Nālaṭiyār comes under the collection works known as patiṇ̱eṇkḹḻkkaṇakkunūlkal (didactic works) Even though the twosome works narrate moral maxims for humanity in universal manner, the concept of destiny occupies prominent place in the aforesaid works. Jainism and Buddhism lay more emphasis on human effort than destiny in the path of liberation and religious life proposed by the two isms is logically vehemently opposed to supremacy of destiny. Pañca mahā vratas of Jainism and eightfold path of Buddhism challenge command of destiny. Ajivikas’ contribution to very concept of destiny cannot be completely ruled out from the sangam period of early Tamils and it can be found that destiny plays a pivotal role in Hindu epics and purāṇas and there is no contradiction between God’s will and destiny in a vaiṣṇava tradition. On the contrary, pure devotion and self-surrender are the unconquerable weapons to conquer destiny in Saivā tradition. This study analyses destiny in Tirukkuṟal and Nālaṭiyār in the wider and complex social, historical and philosophical back ground of Tamil Nadu.
TELECOMMUNICATIONS ENVIRONMENT AND PROBLEMS OF DIGITAL FOOTPRINT DATA OF SUBJECTS OF DIGITAL SOCIETY
Authors: КИЗИМА С.В. , КИДАЛОВ Ф.В. , ПАЛЬЦИН Д.А. 
Published: December 2021

Статья посвящена проблематике большихданных, подходам к организации хранения, использования и безопасности данных цифрового следа субъектов-пользователей цифровых сетевых сервисных систем. Рассмотрены принципы и способы хранения больших данных и проблемы реализации прав пользователей на свой «цифровой след» в телекоммуникационной среде сетевых сервисных систем. Статья носит дискуссионный характер и призывает к совместному поиску оптимальных вариантов эффективного использования данных цифрового следа в интересах как каждого гражданина, так и цифрового общества в целом.
The article deals with big data problematic, approaches to the organization of storage, use, and data security of digital footprint of subjects-users of digital network service systems. Principles and methods of storage of big data and problems of realization of users' rights to their "digital footprint" in the telecommunications environment of network service systems are considered. The article is debatable and calls for a joint search for the optimal and effective use of digital footprint data for the benefit of every citizen as well as the digital society as a whole.
ESTIMATION OF THE MESSAGE TRANSMISSION PROBABILITY IN CHANNELS WITH ERRORS PACKETS
Authors: МАСЛАКОВ М.Л. , КУДРЯШОВА С.А. 
Published: December 2021

Рассмотрена передача сообщений в каналах с пачками ошибок. Реализована модель дискретного канала с формированием как одиночных, так и пачек ошибок с заданной вероятностью. Модель позволяет получить оценки вероятности потери сообщений для различных условий. Представлены результаты моделирования.
The paper deals with the transmission of messages over channels with error packets. A model of a discrete channel has been designed with the formation of both single errors and packets of errors with a given probability. The model provides estimates of the message error rate for various conditions. The results of the numerical simulation are presented.
INFORMATION AND TELECOMMUNICATION NETWORK SECURITY MANAGEMENT METHODOLOGY
Authors: КАРПОВ М.А. , МИТРОФАНОВ М.В. , ЛАУТА О.С. , ПАЛЬЦИН Д.А. 
Published: December 2021

Исследуются вопросы ситуативного управления сложными динамическими системами. Анализируются релевантные работы в области ситуативного управления системами защиты. Приводятся результаты разработки алгоритма эффектив -ного управления, позволяющего уменьшать пространство состояний управляемого объекта. Показано, что представленная методика позволяет спрогнозировать количество итераций управления в зависимости от сегмента пространства состояний и выбранного количества переходов. Данный подход позволяет воздействовать на сложные динамические системы в реальном времени, причем затраты на вычислительные мощности системы управления и ее подсистем сокращаются.
The issues of situational management of complex dynamic systems are investigated. Relevant works in the field of situational management of protection systems are analyzed. The article presents the results of the development of an efficient control algorithm that allows reducing the state space of the controlled object. The presented technique makes it possible to predict the number of control iterations depending on the segment of the state space and the selected number of transitions. This approach allows you to act on complex dynamic systems in real time, while the cost of the computing power of the control system and its subsystems is reduced.
Keywords: INFORMATION AND TELECOMMUNICATION NETWORK, SCRIPT FORECAST, MANAGEMENT SYSTEM, SITUATIONAL MANAGEMENT, ITCN SECURITY SYSTEM
ASSOCIATION OF NOVEL POLYMORPHISM OF ESR2 GENE (G40100A) WITH PRODUCTION TRAITS OF BROWN LOCAL IRAQI CHICKEN
Authors: Abu-Rekaiba R.. I. A. , Razuki W. M. , AL-Anbari E. H. 
Published: December 2021

The estrogen receptor 2 (ESR2) plays a crucial role in the growth and development of follicles and ovulation in chickens. The aim of this study was detect the association of estrogen receptor 2(ESR2) gene polymorphisms with the production performance of brown local Iraqi chicken. A total of 104 hens from the F4th generation of local chicken selected for high egg yield were used. The novel SNP(G40100A) transition within third prime untranslated region (3 prime UTR) of ESR2 gene. Three genotypes were found: Wild(GG), Heterozygous(GA), and Homozygous(AA) through (PCR-DAN sequencing). Chi-square analysis showed no significant in genotypic and allelic frequencies for SNP which were agreement with Hardy-Weinberg equilibrium. The genotypes GG and GA were significantly superior with age at sexual maturity compared to AA genotype. The genotype GA was significantly associated with hen day egg production (HDEP) at 30 weeks compared to genotype AA, as well as the genotype GA highest significant variance was reported comparing with the GG genotype in HDEP at 45 and 60 weeks, thus, the study recommends to exploit this ESR2 gene polymorphism (G40100A) as promising marker in breeding program via, the selection of individuals carrying the genotype GA, characterized by the high egg production.
ALLELIC VARIATIONS OF SOS, HVNHX AND SDO GENES IN SOME BARLEY (Hordeum Vulgare L.) GENOTYPES
Authors: Taher D. , AL-Aouda A. , Lawand S. 
Published: December 2021

This study has been carried out at the Biotechnology Lab., Department of Field Crops, Faculty of Agriculture, Damascus University during the growing season 2019 - 2020, in order to detect the variations of SOS, HVNHX and SDO genes in different barley genotypes. Clear variations in the SOS, HVNHX and SDO genes, which are responsible for salinity tolerance were found among the investigated genotypes. It has been found that the variation in the amplicon size between loci per gene was very high in some cases, while there was a high degree of symmetry in other cases, and could be easily distinguished on 2% Agarose gel. The PCR results for the SOS genes (SOS1, SOS2, SOS3), HVNHX genes (HVNHX1, HVNHX2, HVNHX3) and SDO genes (Cu/Zn SODII, Cu/Zn SODI, CAT, GRI , APXIII) have shown only one morphological pattern in most of the studied genotypes, while revealed two patterns for the SOS3 gene, but the rest of genes (HVNHX1, HVNHX2, HVNHX3 Cu/Zn SODI, CAT) exhibited only one morphological pattern. The SOS3 was superior in the number of polymorphic patterns, as the number of total patterns was 14 in all the studied genotypes, but the Cu/Zn SODI showed the least number of polymorphic patterns with only 1 pattern, while the largest number (7 patterns) was detected in the genotype (H9), but the two genotypes Fourat9 and Fourat7 showed only one polymorphic pattern.
PREVENTATIVE EFFECTS OF PROBIOTIC (MIACLOST) ON EXPERIMENTALLY INDUCED HYPOCALCEMIC RICKETS IN BROILER CHICKS.
Authors: Ameen N. A. , Abdul Rahman N. R. , Hassan A H 
Published: December 2021

A trial was conducted to study the effects of probiotic (Miaclost) supplement on experimentally induced hypocalcemic rickets in broiler chicks, a total of 180 one-day-old broiler chicks (Ross 308) were randomly divided into three equal groups 60 chicks per group with 3 replicates (20 birds /replicate) the dietary treatments consisted of a normal ration for G1, calcium-deficient ration 5% for G2 and calcium-deficient ration with addition of probiotics in drinking water for G3.Initial signs of rickets have been observed at 35-day of age in G2.while, in G1 and G3 no clinical signs observed, the gross lesions appeared enlargement of parathyroid gland, costochondral junction and increase in the width of growth plate of tibial bone of G2 whereas no gross lesions recorded in G1 and G3, the histopathological examination of parathyroid gland in G2 there were a focal parathyroid hyperplasia and increasing in numbers of syncytial cells and normal in G1 and G3, no intestinal histopathological changes in G1 and G2 and increase in height and width of the intestinal villi in probiotic group G3. Marked increase in the thickness of proliferation zone within growth plate of tibia bone in G2 and normal thickness in G1 and G3. the serum biochemical analysis of calcium of G2 recorded significantly low level in G2 and high level in G3 comparatively with G1, finally the serum alkaline phosphatase values were high significantly in G2 and normal in G3, it is concluded that probiotic (MiaClost) can be used as prophylaxis to prevent hypocalcemic rickets in broiler chicks
FUNCTIONAL PROPERTIES OF CATFISH SKIN COLLAGEN HYDROLYSATES
Authors: Ayat A. A. , Shakir K. A. 
Published: December 2021

Collagen hydrolysates were obtained from catfish skin collagen hydrolysis using catfish collagenase, pepsin and trypsin individually and mixed for 15-300min. The degree of hydrolysis , antioxidant activity based on, DPPH radical-scavenging activity (RSA), and reducing power (RP) for all obtained hydro lysates were studied , then the collagenase hydrolysate was (CH) was selected to be evaluated for antibacterial activity , functional properties including solubility, emulsification and foaming properties besides the toxicity . The highest values for RSA (72.5%) has been noticed when DH reached (24.30%) after 30 min. of hydrolysis by collagenase (CH). The water and oil holding capacities for this hydro lysate was compared to that for ASC (acid soluble collagen and PSC (pepsin soluble collagen), the results showed that the values recorded by CH were significantly higher than ASC & PSC. The molecular weight of CH peptides ranged from 180 to 11 Da. as analyzed by SDS- PAGE. The toxicity assay result revealed that CH is safe for human consumption. There was no antibacterial function for CH toward E.coli and S. aureus. At concentration of 2mg/ml. This study suggests that catfish collagen hydro lysate could be a good natural alternative for synthetic antioxidants in food industries.