bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spin correlations in final-state parton showers and jet observables
Authors: Karlberg Alexander , Salam Gavin P. , Scyboz Ludovic , Verheyen Rob 
Published: August 2021

AbstractAs part of a programme to develop parton showers with controlled logarithmic accuracy, we consider the question of collinear spin correlations within the PanScales family of parton showers. We adapt the well-known Collins–Knowles spin-correlation algorithm to PanScales antenna and dipole showers, using an approach with similarities to that taken by Richardson and Webster. To study the impact of spin correlations, we develop Lund-declustering based observables that are sensitive to spin-correlation effects both within and between jets and extend the MicroJets collinear single-logarithmic resummation code to include spin correlations. Together with a 3-point energy correlation observable proposed recently by Chen, Moult and Zhu, this provides a powerful set of constraints for validating the logarithmic accuracy of our shower results. The new observables and their resummation further open the pathway to phenomenological studies of these important quantum mechanical effects.
A critical assessment of black hole solutions with a linear term in their redshift function
Authors: Gregoris Daniele , Ong Yen Chin , Wang Bin 
Published: August 2021

AbstractDifferent theories of gravity can admit the same black hole solution, but the parameters usually have different physical interpretations. In this work we study in depth the linear term$$\beta r$$βrin the redshift function of black holes, which arises in conformal gravity, de Rham–Gabadadze–Tolley (dRGT) massive gravity,f(R) gravity (as approximate solution) and general relativity. Geometrically we quantify the parameter$$\beta $$βin terms of the curvature invariants. Astrophysically we found that$$\beta $$βcan be expressed in terms of the cosmological constant, the photon orbit radius and the innermost stable circular orbit (ISCO) radius. The metric degeneracy can be broken once black hole thermodynamics is taken into account. Notably, we show that under Hawking evaporation, different physical theories with the same black hole solution (at the level of the metric) can lead to black hole remnants with different values of their physical masses with direct consequences on their viability as dark matter candidates. In particular, the mass of the graviton in massive gravity can be expressed in terms of the cosmological constant and of the formation epoch of the remnant. Furthermore the upper bound of remnant mass can be estimated to be around$$0.5 \times 10^{27}$$0.5×1027kg.
A decaying neutralino as dark matter and its gamma ray spectrum
Authors: Aboubrahim Amin , Ibrahim Tarek , Klasen Michael , Nath Pran 
Published: August 2021

AbstractIt is shown that a decaying neutralino in a supergravity unified framework is a viable candidate for dark matter. Such a situation arises in the presence of a hidden sector with ultraweak couplings to the visible sector where the neutralino can decay into the hidden sector’s lightest supersymmetric particle (LSP) with a lifetime larger than the lifetime of the universe. We present a concrete model where the MSSM/SUGRA is extended to include a hidden sector comprised of $$U(1)_{X_1} \times U(1)_{X_2}$$

U

(
1
)

X
1

×
U

(
1
)

X
2

gauge sector and the LSP of the hidden sector is a neutralino which is lighter than the LSP neutralino of the visible sector. We compute the loop suppressed radiative decay of the visible sector neutralino into the neutralino of the hidden sector and show that the decay can occur with a lifetime larger than the age of the universe. The decaying neutralino can be probed by indirect detection experiments, specifically by its signature decay into the hidden sector neutralino and an energetic gamma ray photon. Such a gamma ray can be searched for with improved sensitivity at Fermi-LAT and by future experiments such as the Square Kilometer Array (SKA) and the Cherenkov Telescope Array (CTA). We present several benchmarks which have a natural suppression of the hadronic channels from dark matter annihilation and decays and consistent with measurements of the antiproton background.
Evaluation of the Therapeutic Effects of the Hydroethanolic Extract of Portulaca oleracea on Surgical-Induced Peritoneal Adhesion
Authors: Jaafari Ali , Baradaran Rahimi Vafa , Vahdati-Mashhadian Nasser , Yahyazadeh Roghayeh , Ebrahimzadeh-Bideskan Alireza , Hasanpour Maede , Iranshahi Mehrdad , Ehtiati Sajjad , Rajabi Hamed , Mahdinezhad Mohammadreza , Rakhshandeh Hassan , Askari Vahid Reza 
Published: August 2021

Objective. Peritoneal adhesion (PA) is an abnormal connective tissue that usually occurs between tissues adjacent to damaged organs during processes such as surgery. In this study, the anti-inflammatory and antioxidant effects of Portulaca oleracea (PO) were investigated against postoperative-induced peritoneal adhesion. Methods. Thirty healthy male Wistar rats (

220
±
20

g

, 6-8 weeks) were randomly divided into four groups: (1) normal, (2) control (induced peritoneal adhesion), and (3) and (4) PO extracts (induced peritoneal adhesion and received 100 or 300 mg/kg/day of PO extract for seven days). Finally, macroscopic and microscopic examinations were performed using different scoring systems and immunoassays in the peritoneal lavage fluid. Results. We found that the levels of adhesion scores and interleukin- (IL-) 1β, IL-6, IL-10, tumour necrosis factor- (TNF-) α, transforming growth factor- (TGF-) β1, vascular endothelial growth factor (VEGF), and malondialdehyde (MDA) were increased in the control group. However, PO extract (100 and 300 mg/kg) notably reduced inflammatory (IL-1β, IL-6, and TNF-α), fibrosis (TGF-β1), angiogenesis (VEGF), and oxidative (MDA) factors, while increased anti-inflammatory cytokine IL-10, antioxidant factor glutathione (GSH), compared to the control group. Conclusion. Oral administration of PO improved postoperational-induced PA by alleviating the oxidative factors, fibrosis, inflammatory cytokines, angiogenesis biomarkers, and stimulating antioxidative factors. Hence, PO can be considered a potential herbal medicine to manage postoperative PA. However, further clinical studies are required to approve the effectiveness of PO.
Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms
Authors: Abbott Charles W. , Boyle Sean M. , Pyke Rachel Marty , McDaniel Lee D. , Levy Eric , Navarro Fábio C.P. , Mellacheruvu Dattatreya , Zhang Simo V. , Tan Mengyao , Santiago Rose , Rusan Zeid M. , Milani Pamela , Bartha Gabor , Harris Jason , McClory Rena , Snyder Michael P. , Jang Sekwon , Chen Richard 
Published: August 2021

AbstractPurpose:While immune checkpoint blockade (ICB) has become a pillar of cancer treatment, biomarkers that consistently predict patient response remain elusive due to the complex mechanisms driving immune response to tumors. We hypothesized that a multi-dimensional approach modeling both tumor and immune-related molecular mechanisms would better predict ICB response than simpler mutation-focused biomarkers, such as tumor mutational burden (TMB).Experimental Design:Tumors from a cohort of patients with late-stage melanoma (n = 51) were profiled using an immune-enhanced exome and transcriptome platform. We demonstrate increasing predictive power with deeper modeling of neoantigens and immune-related resistance mechanisms to ICB.Results:Our neoantigen burden score, which integrates both exome and transcriptome features, more significantly stratified responders and nonresponders (P = 0.016) than TMB alone (P = 0.049). Extension of this model to include immune-related resistance mechanisms affecting the antigen presentation machinery, such as HLA allele-specific LOH, resulted in a composite neoantigen presentation score (NEOPS) that demonstrated further increased association with therapy response (P = 0.002).Conclusions:NEOPS proved the statistically strongest biomarker compared with all single-gene biomarkers, expression signatures, and TMB biomarkers evaluated in this cohort. Subsequent confirmation of these findings in an independent cohort of patients (n = 110) suggests that NEOPS is a robust, novel biomarker of ICB response in melanoma.
Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology
Authors: Wallace Kristin , El Nahas Georges J. , Bookhout Christine , Thaxton Jessica E. , Lewin David N. , Nikolaishvili-Feinberg Nana , Cohen Stephanie M. , Brazeal J. Grant , Hill Elizabeth G. , Wu Jennifer D. , Baron John A. , Alekseyenko Alexander V. 
Published: August 2021

Abstract

Immune responses vary in colorectal cancers, which strongly influence prognosis. However, little is known about the variance in immune response within preinvasive lesions. The study aims to investigate how the immune contexture differs by clinicopathologic features (location, histology, dysplasia) associated with progression and recurrence in early carcinogenesis. We performed a cross-sectional study using preinvasive lesions from the surgical pathology laboratory at the Medical University of South Carolina. We stained the tissues with immunofluorescence antibodies, then scanned and analyzed expression using automated image analysis software. We stained CD117 as a marker of mast cells, CD4/RORC to indicate Th17 cells, MICA/B as a marker of NK-cell ligands, and also used antibodies directed against cytokines IL6, IL17A, and IFNγ. We used negative binomial regression analysis to compare analyte density counts by location, histology, degree of dysplasia adjusted for age, sex, race, and batch. All immune markers studied (except IL17a) had significantly higher density counts in the proximal colon than distal colon and rectum. Increases in villous histology were associated with significant decreases in immune responses for IL6, IL17a, NK ligand, and mast cells. No differences were observed in lesions with low- and high-grade dysplasia, except in mast cells. The lesions of the proximal colon were rich in immune infiltrate, paralleling the responses observed in normal mucosa and invasive disease. The diminishing immune response with increasing villous histology suggests an immunologically suppressive tumor environment. Our findings highlight the heterogeneity of the immune responses in preinvasive lesions, which may have implications for prevention strategies.

Prevention Relevance:
Our study is focused on immune infiltrate expression in preinvasive colorectal lesions; our results suggest important differences by clinicopathologic features that have implications for immune prevention research.
Uptake of Genetic Testing Among Patients with Cancer At Risk for Lynch Syndrome in the National Health Interview Survey
Authors: Actkins Ky'Era V. , Srinivasan Swetha , Spees Lisa P. , Turbitt Erin , Allen Caitlin G. , Roberts Megan C. 
Published: August 2021

Abstract
Lynch syndrome is the most common inherited cancer syndrome that increases the risk of developing colorectal and endometrial cancer. Universal screening guidelines were first recommended by the Centers for Disease Control and Prevention (CDC) in 2009 and are updated annually by multiple societies. Therefore, one would expect genetic testing rates to increase over time. But testing remains underutilized among those with colorectal or endometrial cancer, even though early detection can improve prognosis and survival rates. In this study, we aimed to understand differences in genetic testing uptake among those with colorectal cancer or endometrial cancer from 2005, 2010, 2015, using data from the National Health Interview Survey (NHIS). We examined genetic testing uptake across cancer-type, age (≤50 or ≥51), sex, race, insurance, and education using a χ2 statistical analysis. Despite an upward genetic testing trend in 2010, we found no significant differences in genetic testing uptake over time. In 2010, non-White individuals experienced the highest increase from 2005 in comparison with White individuals. However, genetic testing rates declined for both groups by 2015. Our findings show that genetic testing for colorectal cancer and endometrial cancer did not increase over a 10-year period in spite of guidelines that recommend testing.
Prevention Relevance: Genetic testing uptake for colorectal cancer and endometrial cancer has not increased over a 10-year period in spite of universal screening guidelines. More genetic testing education is needed at the provider and patient level to improve screening strategies for cancer patients who are most at risk for Lynch syndrome.
Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses
Authors: Yang Yanping , McCloskey Jaclyn E. , Yang Huan , Puc Janusz , Alcaina Yago , Vedvyas Yogindra , Gomez Gallegos Angel A. , Ortiz-Sánchez Elizabeth , de Stanchina Elisa , Min Irene M. , von Hofe Eric , Jin Moonsoo M. 
Published: August 2021

AbstractAdoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated unparalleled responses in hematologic cancers, yet antigen escape and tumor relapse occur frequently. CAR T-cell therapy for patients with solid tumors faces even greater challenges due to the immunosuppressive tumor environment and antigen heterogeneity. Here, we developed a bispecific CAR to simultaneously target epithelial cell adhesion molecule (EpCAM) and intercellular adhesion molecule 1 (ICAM-1) to overcome antigen escape and to improve the durability of tumor responses. ICAM-1 is an adhesion molecule inducible by inflammatory cytokines and elevated in many types of tumors. Our study demonstrates superior efficacy of bispecific CAR T cells compared with CAR T cells targeting a single primary antigen. Bispecific CAR T achieved more durable antitumor responses in tumor models with either homogenous or heterogenous expression of EpCAM. We also showed that the activation of CAR T cells against EpCAM in tumors led to upregulation of ICAM-1, which rendered tumors more susceptible to ICAM-1 targeting by bispecific CAR T cells. Our strategy of additional targeting of ICAM-1 may have broad applications in augmenting the activity of CAR T cells against primary tumor antigens that are prone to antigen loss or downregulation.
The SRSF4–GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy
Authors: Larrasa-Alonso Javier , Villalba-Orero María , Martí-Gómez Carlos , Ortiz-Sánchez Paula , López-Olañeta Marina M. , Rey-Martín M. Ascensión , Sánchez-Cabo Fátima , McNicoll François , Müller-McNicoll Michaela , García-Pavía Pablo , Lara-Pezzi Enrique 
Published: August 2021

Rationale:
RBPs (RNA-binding proteins) play critical roles in human biology and disease. Aberrant RBP expression affects various steps in RNA processing, altering the function of the target RNAs. The RBP SRSF4 (serine/arginine-rich splicing factor 4) has been linked to neuropathies and cancer. However, its role in the heart is completely unknown.

Objective:
To investigate the role of SRSF4 in the heart.

Methods and Results:
Echocardiography of mice specifically lacking SRSF4 in the heart (SRSF4 KO) revealed left ventricular hypertrophy and increased cardiomyocyte area, which led to progressive diastolic dysfunction with age. SRSF4 KO mice showed altered electrophysiological activity under isoproterenol-induced cardiac stress, with a post-QRS depression and a longer QT interval, indicating an elevated risk of sudden cardiac death. RNA-Seq analysis revealed expression changes in several long noncoding RNAs, including GAS5 (growth arrest-specific 5), which we identified as a direct SRSF4 target in cardiomyocytes by individual-nucleotide-resolution cross-linking and immuno-precipitation. GAS5 is a repressor of the GR (glucocorticoid receptor) and was downregulated in SRSF4 KO hearts. This corresponded with elevated GR transcriptional activity in cardiomyocytes, leading to increases in hypertrophy markers and cell size. Furthermore, hypertrophy in SRSF4 KO cardiomyocytes was reduced by overexpressing GAS5.

Conclusions:
Loss of SRSF4 expression results in cardiac hypertrophy, diastolic dysfunction, and abnormal repolarization. The molecular mechanism underlying this effect involves GAS5 downregulation and consequent elevation of GR transcriptional activity. Our findings may help to develop new therapeutic tools for the treatment of cardiac hypertrophy and myocardial pathology in patients with Cushing syndrome.
Sea surface salinity reemergence in an updated North Atlantic in-situ salinity data set
Authors: Frankignoul Claude , Kestenare Elodie , Reverdin Gilles 
Published: August 2021

AbstractMonthly sea surface salinity (SSS) fields are constructed from observations, using objective mapping on a 1°x1° grid in the Atlantic between 30°S and 50°N in the 1970-2016 period in an update of the data set of Reverdin et al. (2007). Data coverage is heterogeneous, with increased density in 2002 when Argo floats become available, high density along Voluntary Observing Ship lines, and low density south of 10°S. Using lag correlation, the seasonal reemergence of SSS anomalies is investigated between 20°N and 50°N in 5°x5° boxes during the 1993-2016 period, both locally and remotely following the displacements of the deep mixed-layer waters estimated from virtual float trajectories derived from the daily AVISO surface geostrophic currents. Although SSS data are noisy, local SSS reemergence is detected in about half of the boxes, notably in the northeast and southeast, while little reemergence is seen in the central and part of the eastern subtropical gyre. In the same period, sea surface temperature (SST) reemergence is found only slightly more frequently, reflecting the short data duration. However, taking geostrophic advection into account degrades the detection of remote SSS and even SST reemergence. When anomalies are averaged over broader areas, robust evidence of a second and third SSS reemergence peak is found in the northeastern and southeastern parts of the domain, indicating long cold-season persistence of large-scale SSS anomalies, while only a first SST reemergence is seen. An oceanic reanalysis is used to confirm that the correlation analysis indeed reflects the reemergence of subsurface salinity anomalies.
Evaluation of the energy consumption of container diesel trucks in a container terminal: A case study at Klaipeda port
Authors: Eglynas Tomas , Jakovlev Sergej , Jankunas Valdas , Didziokas Rimantas , Januteniene Jolanta , Drungilas Darius , Jusis Mindaugas , Pocevicius Edvinas , Bogdevicius Marijonas , Andziulis Arunas 
Published: August 2021

Introduction: In the paper, we examine the energy consumption efficiency of specialized container diesel trucks engaged in container transportation at a seaport terminal. Objectives: Using the container terminal at Klaipėda in Lithuania as the background for the research, we produced an improved energy consumption model for measuring the theoretical energy consumption and regeneration of diesel trucks at the terminal and provide a comparative analysis. Methods: We created a mathematical model which describes the instantaneous energy consumption of the diesel trucks, taking into account their dynamic properties and the overall geometry of their routes—“Ship-Truck-Stack-Ship”—using the superposition principle. We investigated other critical parameters relevant to the model and provide a statistical evaluation of the transportation process using data from a case study of Klaipėda port, where we collected measurements of container transportation parameters using georeferenced movement detection and logs from wireless equipment positioned on the diesel-powered container trucks. Results: The modeling results showed that an instantaneous evaluation of energy consumption can reveal areas in the container transportation process which have the highest energy loss and require the introduction of new management and process control initiatives to address the regulations which are designed to decrease harmful industrial emissions and encourage novel technologies and thereby increase the eco-friendliness of existing systems. Conclusion: Based on the research results, the article can provide a reference for the estimation of diesel truck efficiency in seaport terminal operations.
Benefits of Using the Invertebrate Model Organism C. Elegans in an Inquiry-Based Laboratory Activity
Authors: Kallarackal Angy J. 
Published: August 2021

Background: The goals of laboratory experiences include developing knowledge base, research skills, and scientific communication abilities. Objective: The aim was to assess an inquiry-based laboratory activity using the model organism Caenorhabditis elegans in relation to learning goals. Method: Students in a Biopsychology laboratory course worked in groups to test the effect of various drugs (e.g., nicotine, ethanol, fluoxetine, and melatonin) on C. elegans behavior. The activity included literature review, experimental design, and a final lab report. A cumulative final exam included a synaptic communication question related to the content of the activity. Results: Students showed better retention of laboratory-related content compared to other topics from the course, as demonstrated through performance on the final exam and were able to replicate previous research demonstrating effects of drug on locomotion. However, students did not improve writing ability compared to performance on a previous American Psychological Association style lab report. Conclusion: This study demonstrates that using a student-designed, multi-week laboratory assignment in an undergraduate Biopsychology course supports the growth of psychology knowledge and the development of research skills. Teaching Implications: Instructors should consider using the described laboratory activity for biopsychology or behavioral neuroscience classes or consider similarly designed laboratory formats for other courses in Psychology.
Power Relations in Reproductive Decisions Under the Transforming Family Planning Policy in China
Authors: Shen Yang , Jiang Lai 
Published: August 2021

China’s family planning policy has had a profound influence on individuals and families for the past 30 years. The universal two-child policy implemented in 2016 is its most relaxed form. The consequences of the policy transitions are worthwhile to explore . By interviewing 26 middle class mothers who gave birth to a second child during the policy transformation, we consider women’s accounts of their reproductive decisions-making processes. We found that the participants exerted strong agency in their reproductive decisions, but meanwhile they were reproducers and embodiments of traditional culture, population policies and patriarchal power. They internalised various modes of power that dictate how women should regulate their bodies, reflecting the mechanisms of self-governance. Self-governance functions as a subtle technique of conflict avoidance through which explicit conflicts are dissolved and transformed into intrapersonal self-adjustment and personal struggle. Our research broadens the conceptualisation of self-governance by incorporating relational dynamics using evidence from China.