bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combinatorial library design and virtual screening of cryptolepine derivatives against topoisomerase IIA by molecular docking and DFT studies
Authors: Maria  , Khan Zahid , Kuznetsov Aleksey E. 
Published: June 2021

Abstract
Various computational approaches have received ever-growing role in the design of potential inhibitors of the topoisomerase 2 (TOP2A) for cancer treatment. TOP2A plays a key role in the deoxyribonucleic acid (DNA) replication before cell division and thus facilitates the growth of cells. This TOP2A function can be suppressed by targeting it with potential inhibitors in cancer cells to terminate the uncontrolled cell division. Among potential inhibitors, cryptolepine has higher selectivity along with the ability to intercalate into DNA, effectively blocking TOP2A and ceasing cell division in cancer cells. However, this compound has drawbacks of being nonspecific and possessing relatively low affinity. Therefore, a combinatorial library of 31,114 cryptolepine derivatives was designed and virtually screened by molecular docking to predict the molecular interactions between the cryptolepine derivatives and TOP2A using cryptolepine as a standard. All the binding poses of cryptolepine derivatives for TOP2A were investigated to calculate binding energy. The compounds with the database numbers 8618, 907, 147, 16755, and 8186 scored the highest binding energies, −9.88, −9.76, −9.75, −9.73, and −9.72 kcal/mol, respectively, and the highest binding affinities while the cryptolepine binding energy is −6.09 kcal/mol. The strong binding interactions of these derivatives show that they can be used as potent TOP2A inhibitors and act as more effective anticancer agents than cryptolepine itself. The interactions of these derivatives with different amino acid residues were also observed and analyzed. A comprehensive understanding of the interactions of the proposed derivatives with TOP2A helped for searching more novel and potent drug-like molecules for anticancer therapy. This computational study suggests useful references to understand inhibition mechanisms that will help in the further modifications of TOP2A inhibitors. Moreover, the DFT study of the derivatives with the highest binding energies was performed, helping to further understand the binding affinities of these compounds.
Interest Group Politics and Its Transformation in Japan
Authors: Yamamoto Hidehiro 
Published: June 2021

The political reforms that have been going on since the 1990s have drastically changed the face of politics in Japan. The most significant of these reforms was the change of government, which brought an end, albeit only once, to the long-standing Liberal Democratic Party (LDP) regime. These changes were expected to change the power structure by altering the contact of interest groups with political elites. I examine this issue based on a longitudinal survey conducted in four rounds between 1997 and 2017.
The results show a robust structure of interest group politics, although the features were weakening. That is, contacts with the LDP and the bureaucracy were sources of political influence for interest groups. The impact of the two-party system and its setbacks are seen in the change in contact with the Democratic Party of Japan (DPJ). However, The DPJ did not function as a source of interest representation.
Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study
Authors: Bharmal Sakina H , Kimita Wandia , Ko Juyeon , Petrov Maxim S 
Published: June 2021

Objective
Early identification of individuals at high risk for metabolic derangements after an attack of acute pancreatitis (AP) is critical with a view to tertiary preventing of this disease. The aim was to investigate whether fasting pancreatic and gut hormones at baseline were predictive of future risk of new-onset prediabetes after acute pancreatitis (NOPAP) in individuals with non-necrotising AP.

Methods
This was a prospective longitudinal cohort study that included 69 consecutive non-diabetic participants with AP, of whom 55% (n = 38) had normoglycaemia both at baseline and during follow-up, 25% (n = 17) had prediabetes both at baseline and during follow-up, and 20% (n = 14) were normoglycaemic at baseline but developed NOPAP during follow-up. The associations between the study groups and circulating fasting levels of pancreatic and gut hormones (insulin, glucagon, C-peptide, amylin, glucose-dependent insulinotropic peptide, glucagon-like peptide-1, pancreatic polypeptide, and peptide YY) were studied using multinomial regression in both unadjusted and adjusted analyses.

Results
Elevated plasma insulin and glucagon at baseline were significantly associated with NOPAP (adjusted odds ratio 1.99, 95% CI 1.01 to 3.92 and adjusted odds ratio 3.44, 95% CI 1.06 to 11.19, respectively). The same hormones had no significant association with antecedent prediabetes in AP. The other studied hormones were not significantly associated with the study groups.

Conclusions
Normoglycaemic AP individuals with elevated fasting levels of insulin and glucagon at baseline constitute a high-risk group for future NOPAP.
Naród a Eucharystia. Sekca polska na XXIII międzynarodowym kongresie eucharystycznym w Wiedniu (1912)
Authors: Janicki Jan Józef 
Published: June 2021

First Eucharistic congresses were first established in France, which for centuries stood out among Catholic nations for its special worship of the Blessed Sacrament. The first international congress was held in 1881 in Lille. The 23rd International Eucharistic Congress took place in 11-15 September 1912 in Vienna under the auspices of Emperor Franz Joseph I of Austria. The article discusses the activity of the Polish section at the congress.
Ideowe i artystyczne wartości obrazu Matki Bożej, namalowanego przez Adolfa Hyłę, według projektu Sł. B. Pauli Zofii Tajber
Authors: Wanat Benignus 
Published: June 2021

The subject of the analysis is a picture of the Mother of God painted as the Immaculate in full form, in two versions, differing in the symbols of the Holy Trinity. Both paintings were made according to a preliminary design, which had been performed in pastels on carton. Artist Adolf Hyła painted them according to an account by Mother Paula Zofia Tajber, founder of the Gathering of the Most Holy Soul of Our Lord Jesus, who on 13 September 1953 had a vision in which Our Lady appeared to her in the gathering's original chapel in Prądnik Biały.
Chrześcijańskie wpływy na muzułmańską antropologię we wczesnym średniowieczu na przykładzie wybranych tradycji
Authors: Kościelniak Krzysztof 
Published: June 2021

Exposing an exceptional closeness of God to human being, the mystery of incarnation is a fundamental truth of Christianity. This phenomenon is unknown to Islam, which puts strong emphasis on the transcendence of the Creator. Nevertheless, due to the acculturation in the 7th to 9th century, some thoughts on divine proximity permeated the utterances attributed to Muhammad.
Rok świętego Stanisława Biskupa Męczennika w diecezji tarnowskiej (7 V 1978 - 30 IX 1979)
Authors: Piech Stanisław 
Published: June 2021

The idea of “St. Stanislaus’Year” in Tarnów’s diocese was inspired by cardinal Karol Wojtyła, who prompted it to bishop Jerzy Ablewicz to commemorate the ninehundredth anniversary of a martyr’s death of St. Stanislaus. On Sunday, May 7, 1978 a celebration took place in Szczepanów, as announced in the letters of the Bishop of Tarnów the year before the nine-hundredth anniversary ofa martyr’s death of St. Stanislaus, thus marking the beginning of the ‘Year of St. Stanislaus’ in Tamow’s diocese. Cardinal Karol Wojtyła presided over a Holy Mass, which was concelebrated by the bishops of the dioceses in which St. Stanislaus of Szczepanów is especially venerated. The homily was preached by the Primate of Poland, cardinal Stefan Wyszyński. The Bishop of Tarnów said a prayer which he had written for the occasion: A prayer o f the congregation o f the diocese o f Tarnów to St. Stanislaus, its patron saint. The Mass ended with cardinal Karol Wojtyła’s solemnblessing extended to the pilgrims gathered at the field-altar with the reliquary with the Saint’s skull, which had been brought from the Wawel Cathedral. In this solemn service participated 44 bishops from Poland and from abroad. The main Sunday ceremony was followed by its octave (from May 8 to 14). Pilgrims from Tamow’s diocese and from other parts of Poland and from abroad were coming to Szczepanów throughout the year. ‘St. Stanislaus’ Year’ in the diocese of Tarnów finished on September 30, 1979 with an all-diocesan pilgrimage to Wawel and Skałka in Cracow.The “Year of St. Stanislaus’ was the time of deepening religious awareness as well as moral and spiritual revitalisation of the diocese. Pastoral activity was focused primarily on the strengthening of religious beliefs and forming moral attitudes of the faithful. A special emphasis was laid on the sobriety of the diocesans. Within the Parish Apostolate of Sobriety, the so called Circles of St. Stanislaus were created with an aim to propagate abstemiousness from alcoholic beverages. A visible enlivening of the worship of St. Stanislaus in the diocese was observed.
Theatrum passio sancti Stanislai. Some thoughts on the role of Kraków cathedral as the shrine of St Stanisław
Authors: Rożnowska-Sadraei Agnieszka 
Published: June 2021

On 8 September 1253 bishop Stanisław of Szczepanów was canonised in the basilica of St Francis at Assisi. A year later his relics were elevated to the altar in the centre of the crossing of the so-called second Romanesque cathedral on the ancient Wawel hill at Kraków. This elevation transformed the church, which had functioned for centuries as the seat of the second most important bishop in the country, into the centre of St Stanisław’s cult. In time the cathedral acquired other functions, becoming the Polish coronation church and royal necropolis, a true Kónigskirche, as well as undergoing numerous architectural transformations. All the transformations, especially in the western part of the church, were to a great degree linked with the presence of the saint’s shrine. Yet in the past students of the cathedral focused mainly on the changes in the structural fabric of the building. Only a few scholars have devoted their attention to other issues such as patronage or an ideological programme and, most importantly, to the study of the church as the main sanctuary of St Stanislaw.
Archidiecezja lwowska porządku łacińskiego w świetle schematyzmu archidiecezjalnego z 1939 r.
Authors: Kumor Bolesław 
Published: June 2021

Miasto Lwów było jedyną w Europie rezydencją trzech metropolitówkatolickich. Metropolia łacińska wspominana jest już w 1367 r. Artykuł w sposób syntetyczny omawia jej dzieje.
Kult św. Magdaleny de Pazzi w barokowym Krakowie
Authors: Małecki Jan 
Published: June 2021

W drugiej połowie XVII wieku Kraków wszedł w okres upadku. Powielkiej zarazie lat 1651-1652 i zniszczeniach spowodowanych tragiczną wojną ze Szwecją z trudem dźwigał się z ruin. Liczba ludności wydatnie spadła a życie gospodarcze znacznie osłabło, co było widoczne zwłaszcza w poważnym skurczeniu się obrotów handlowych. Pewne ożywienie następowało tylko w okresie wielkich uroczystości państwowych, tzn. koronacji królewskich i związanych z nimi obrad sejmów koronacyjnych. Szybciej następowała tylkoodbudowa obiektów kościelnych. Zdumieniem napawa rychła restauracja zniszczonych kościołów, a nawet wznoszenie nowych budowli sakralnych, nierzadko okazałych i odznaczających się dużymi walorami artystycznymi. W okresie tym rozwinął się kult Katarzyny de Pazzi (w zakonie Maria Magdalena), florenckiej karmelitanki.
Z działalności Wydziału Historii Kościoła Papieskiej Akademii Teologicznej w latach 1981-1989
Authors: Piech Stanisław 
Published: June 2021

Motu proprio "Beata Hedvigis" papieża Jana Pawła II z dnia 8 grudnia1981 r. została powołana do życia Papieska Akademia Teologiczna w Krakowie. "...Ustanawiamy na zawsze i erygujemy mocą tego Pisma i powagą naszą Apostolską Papieską Akademię Teologiczną w Krakowie, przyznając jej prawa, honory, przywileje i obowiązki, jakie w całym katolickim świecie przysługują tego rodzaju Uczelniom" - pisał papież w tym dokumencie - "Akademia, składająca się obecnie z trzech Wydziałów kościelnych: świętej teologii, filozofii i historii Kościoła, winna rządzić się prawami akademickimi Kościoła" /AAS74:1982 p. 371-372/.
Pengembangan Pembelajaran Kebugaran Jasmani Unsur Kelincahan Berbasis Multimedia Interaktif
Authors: Arief Muhammad Ghazali , Kurniawan Ari Wibowo , Kurniawan Rama 
Published: June 2021

Abstract: This development research aims to develop learning of physical fitness agility elements based on interactive multimedia in SMP Negeri 4 Malang. Using the Research and Development (R&D) model with Lee & Owen. Using a small group trial subject of 20 students and a large group trial subject of 60 students consisting of class VII and class VIII. Based on the results of data analysis obtained from learning experts with a percentage of 93%, physical fitness experts with a percentage of 91%, media experts with a percentage of 90%, small group trials 89%, and large group trials 89%. Based on the analysis of the data that has been obtained, it is concluded that the development product is suitable for use in the learning process.

Abstrak: Penelitian pengembangan ini bertujuan mengembangkan pembelajaran kebugaran jasmani unsur kelincahan berbasis multimedia interaktif di SMP Negeri 4 Malang. Menggunakan model Reseach and Development (R&D) dengan Lee & Owen. Menggunakan subjek uji coba kelompok kecil 20 siswa dan subjek uji coba kelompok besar 60 siswa terdiri dari kelas VII dan kelas VIII. Berdasarkan hasil analisis data yang diperoleh dari ahli pembelajaran dengan persentase 93%, ahli kebugaran jasmani dengan persentase 91%, ahli media dengan persentase 90%, uji coba kelompok kecil 89%, dan uji coba kelompok besar 89%. Berdasarkan analisis data yang telah diperoleh, disimpulkan bahwa produk pengembangan layak digunakan dalam proses pembelajaran.
Pilihan Materi Pembelajaran Guru Pjok SMA dalam Memenuhi Tuntutan Kompetensi Dasar Kurikulum 2013
Authors: Diharjo Muhammad Zaenudin , Wiguno Lokananta Teguh Hari 
Published: June 2021

Abstract: The purpose of this study was to determine the choice of learning materials for PJOK SMA teachers and what are the obstacles that occur in the learning process. This research uses survey research method.. From the results of data analysis, it was found that the choice of learning materials for high school PJOK teachers in Purwosari District and Sukorejo District, Pasuruan Regency, got a grade X percentage of 37.40% which was in the unsuitable category and 45.45% for class XI was included in the inappropriate category. It can be concluded that the choice of learning materials for high school PJOK teachers in meeting the demands of basic competencies in the 2013 curriculum in Purwosari and Sukorejo districts for class X is in the inappropriate category and for class XI is in the less appropriate category. This is influenced by several factors, namely: (1) facilities and infrastructure, (2) school regulations, (3) teacher competence.

Abstrak: Tujuan penelitian ini adalah untuk mengetahui pilihan materi pembelajaran guru PJOK SMA dan apa saja hambatan yang terjadi dalam proses pembelajaran. Penelitian ini menggunakan metdoe penelitian survei. Dari hasil analisis data, diperoleh hasil bahwa pilihan materi pembelajaran guru PJOK SMA di Kecamatan Purwosari dan Kecamatan Sukorejo Kabupaten Pasuruan mendapat persentase kelas X sebesar 37,40% termasuk kategori tidak sesuai dan untuk kelas XI sebesar 45,45% termasuk dalam kategori kurang sesuai. Dapat diambil kesimpulan bahwa pilihan materi pembelajaran guru PJOK SMA dalam memenuhi tuntutan kompetensi dasar dalam kurikulum 2013 di Kecamatan Purwosari dan Kecamatan Sukorejo untuk kelas X termasuk dalam kategori tidak sesuai dan untuk kelas XI termasuk dalam kategori kurang sesuai. Hal tersebut dipengaruhi beberapa faktor yaitu: (1) sarana dan prasarana, (2) peraturan sekolah, (3) kompetensi guru.
Survei Keterampilan Teknik Dasar Bolavoli Ekstrakurikuler Bolavoli Sekolah Menengah Atas
Authors: Masroni Arif Hadi , Hariyanto Eko 
Published: June 2021

Penelitian ini bertujuan untuk mengetahui keterampilan teknik dasar service, passing, smash, block bolavoli peserta ekstrakurikuler bolavoli SMAN 1 Batu dan SMKN 1 Batu. Metode penelitian yang digunakan dalam penelitian ini adalah metode survei. Sampel dalam penelitian ini diambil menggunakan teknik probability proportional random sampling berjumlah 40 orang peserta ekstrakurikuler bolavoli SMK Negeri 1 Kota Batu dan SMA Negeri 1 Kota Batu. Instrumen pada penelitian ini menggunakan tes keterampilan bolavoli dari AAHPRED untuk tes service dan passing, untuk tes smash dan block dalam penelitian ini menggunakan BATTERY TEST bolavoli. Hasil tes siswa dianalisis menggunakan kriteria Penilaian Acuan Norma (PAN). Secara keseluruhan keterampilan teknik dasar bolavoli peserta ekstrakurikuler kedua sekolah tergolong cukup. Perlu adanya perbaikan jadwal dan program latihan, sehingga penguasaan keterampilan teknik dasar bolavoli bisa merata dan lebih baik dalam bermain bolavoli.
Pengembangan Media Biblioedukasi Buku Cerita “Scars Make You Strong” untuk Meningkatkan Self-Esteem Anak di Pondok Tahfidz Quran LAZNAS Nurul Hayat Malang
Authors: Roba’ah Siti Fatimah , Ramli M , Muslihati Muslihati 
Published: June 2021

Abstract: This research aims to develop educational bibliographic media "Scars Make You Strong" to Increase Self-Esteem of children in Pondok Tahfidz Quran LAZNAS Nurul Hayat Malang. This study was developed to help facilitate counseling teachers in providing group guidance interventions using bibli education techniques. The scope of this research is the bibliographic media of the story book "Scars Make You Strong" to increase the self-esteem of the adolescent children. This study uses the model Research and Development developed by Borg and Gall (1983) with the following steps: data collection, planning, product development, testing (BK material expert and media expert), revision of the results of expert testing and candidate testing users, revised trial results, and the final product. Expert testing and field testing of prospective users were analyzed using quantitative data analysis using the formula average (mean) and qualitative data analysis. The validity index of expert and prospective user tests shows high criteria and meets acceptability, namely usability, accuracy, convenience, and attractiveness, so that the product is feasible and can be given to prospective users of story books, namely children in the cottage, and guidebooks for use for counseling teachers / guidance teachers.
Abstrak: Penelitian ini bertujuan untuk mengembangkan media biblioedukasi Buku Cerita Bergambar “Scars Make You Strong” untuk Meningkatkan Self-Esteem anak di Pondok Tahfidz Quran LAZNAS Nurul Hayat Malang. Penelitian ini dikembangkan guna membantu memudahkan guru BK dalam pemberian intervensi bimbingan kelompok menggunakan teknik biblioedukasi. Ruang lingkup dalam penelitian ini adalah media biblioedukasi buku cerita “Scars Make You Strong” untuk meningkatkan self-esteem anak pondok. Penelitian ini menggunakan model Research and Development yang dikembangkan oleh Borg dan Gall (1983) dengan langkah : melakukan pengumpulan data, perencanaan, pengembangan produk, uji coba (ahli materi BK dan ahli media), revisi dari hasil uji ahli dan uji calon pengguna, revisi hasil uji coba, serta produk akhir. Uji ahli dan uji lapangan calon pengguna dianalisis menggunakan analisis data kuantitatif menggunakan rumus rata-rata (mean) dan analisis data kualitatif. Indeks validitas uji ahli dan calon pengguna menunjukkan kriteria yang tinggi dan memenuhi akseptabilitas yakni kegunaan, ketepatan, kemudahan, dan kemenarikan, sehingga produk layak dan dapat diberikan pada calon pengguna buku cerita yakni anak di pondok, dan buku panduan penggunaannya untuk guru BK/guru pembina.
Studi Komparatif Mengenai Kepercayaan Diri Siswa antara Kelompok Siswa Jalur Zonasi dengan Kelompok Siswa Jalur Prestasi Tahun Ajaran 2020/2021 di SMP Negeri 25 Kota Malang
Authors: Ramadhan Firnanda Imam , Atmoko Adi , Radjah Carolina L. 
Published: June 2021

Abstract: This research aims to determine whether or not there is a difference in self-confidence between the zoning path student group and the achievement path student groups at SMPN 25 Kota Malang. This research uses a quantitative approach with a comparative method. The population of this research is 122 students with 95 samples. The hypothesis test used in this research is the Independent-Sample T Test. From the results of the hypothesis test, it states that the significance value (Sig.) is 0,288 > 0.05, it means that H0 is accepted and Ha is rejected. Based on the hypothesis test that has been conducted by the researcher, it can be concluded that there is no significant difference between the zoning path student group and the achievement path student group.
Abstrak: Penelitian ini bertujuan untuk mengetahui ada atau tidaknya perbedaan kepercayaan diri antara kelompok siswa jalur zonasi dan kelompok siswa jalur prestasi SMPN 25 Kota Malang. Penelitian ini menggunakan pendekatan kuantitatif dengan metode komparatif. Populasi dari penelitian adalah 122 siswa dengan sampel 94 responden. Uji hipotesis yang digunakan dalam penelitian ini adalah Independent-Sample T Test. Dari hasil uji hipotesis tersebut menyatakan bahwa nilai signifikansinya (Sig.) adalah 0,288 > 0,05 yang artinya bahwa H0 diterima dan Ha ditolak. Berdasarkan uji hipotesis yang telah dilakukan peneliti dapat diambil kesimpulan bahwa tidak ada perbedaan yang signifikan antara kelompok siswa jalur zonasi dengan kelompok siswa jalur prestasi.
Penerapan Teknik Mozaik untuk Meningkatkan Motorik Halus Anak Kelompok A di TK Permata Bunda Kota Malang
Authors: Wahyuningtyas Zahrok Noviana , Kustiawan Usep , Maningtyas Rosyidamayani Twinsari 
Published: June 2021

Abstract: This research aims to improve the fine motoric of group A children in Permata Bunda kindergarten at Malang City through the mosaic technique. The research used Kemis and Mc Taggart’s action research model. The results showed that the application of the mosaic technique can improve children’s fine motor skills as evidenced by an increase from cycle 1 as big as 44,23 percent to be 85,58 percent in cycle 2.
Abstrak: Penelitian ini bertujuan untuk meningkatkan motorik halus anak kelompok A di TK Permata Bunda Kota Malang melalui teknik mozaik. Penelitian menggunakan penelitian tindakan kelas model Kemis dan Mc Taggart. Hasil penelitian menunjukkan bahwa penerapan teknik mozaik dapat meningkatkan motorik halus anak terbukti dengan adanya peningkatan dari siklus 1 sebesar 44,23 persen menjadi 85,58 persen pada siklus 2.