bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Controlling Geomagnetic and Solar Wind Factors for Magnetospheric Chorus Intensity Using Feature Selection Techniques
Authors: Guo Yingjie , Ni Binbin , Fu Song , Wang Dedong , Shprits Y. Y. , Zhelavskaya I. S. , Feng Minghang , Guo Deyu 
Published: December 2021

AbstractUsing over‐5‐year EMFISIS wave measurements from Van Allen Probes, we present a detailed survey to identify the controlling factors among the geomagnetic indices and solar wind parameters for the 1‐min root mean square amplitudes of lower band chorus (LBC) and upper band chorus (UBC). A set of important features are automatically determined by feature selection techniques, namely, Random Forest and Maximum Relevancy Minimum Redundancy. Our analysis results indicate the AE index with zero‐time‐delay dominates the intensity evolution of LBC and UBC, consistent with the evidence that chorus waves prefer to occur and amplify during enhanced substorm periods. Regarding solar wind parameters, solar wind speed and IMF Bz are identified as the controlling factors for chorus wave intensity. Using the combination of all these important features, a predictive neural network model of chorus wave intensity is established to reconstruct the temporal variations of chorus wave intensity, for which application of Random Forest produces the overall best performance.
Examination of Radiation Belt Dynamics During Substorm Clusters: Activity Drivers and Dependencies of Trapped Flux Enhancements
Authors: Rodger Craig J. , Hendry Aaron T. , Clilverd Mark A. , Forsyth Colin , Morley Steven K. 
Published: December 2021

AbstractDynamical variations of radiation belt trapped electron fluxes are examined to better understand the variability of enhancements linked to substorm clusters. Analysis is undertaken using the Substorm Onsets and Phases from Indices of the Electrojet substorm cluster algorithm for event detection. Observations from low earth orbit are complemented by additional measurements from medium earth orbit to allow a major expansion in the energy range considered, from medium energy energetic electrons up to ultra‐relativistic electrons. The number of substorms identified inside a cluster does not depend strongly on solar wind drivers or geomagnetic indices either before, during, or after the cluster start time. Clusters of substorms linked to moderate (100 nT < AE ≤ 300 nT) or strong AE (AE ≥ 300 nT) disturbances are associated with radiation belt flux enhancements, including up to ultra‐relativistic energies by the strongest substorms (as measured by strong southward Bz and high AE). These clusters reliably occur during times of high speed solar winds streams with associated increased magnetospheric convection. However, substorm clusters associated with quiet AE disturbances (AE ≤ 100 nT) lead to no significant chorus whistler mode intensity enhancements, or increases in energetic, relativistic, or ultra‐relativistic electron flux in the outer radiation belts. In these cases the solar wind speed is low, and the geomagnetic Kp index indicates a lack of magnetospheric convection. Our study clearly indicates that clusters of substorms occurring outside of high speed wind streams are not by themselves sufficient to drive acceleration, which may be due to the lack of pre‐cluster convection.
Maximizing the Accuracy of Double Probe Electric Field Measurements Near Perigee: The Case of the Van Allen Probes Instruments
Authors: Lejosne Solène , Bonnell John W. , Wygant John R. , Mozer Forrest S. 
Published: December 2021

AbstractThe Van Allen Probes spacecraft flew through the inner radiation belt and the plasmasphere, probing the extremely dynamic coupling between the thermosphere, the ionosphere and the subauroral magnetosphere. Examining the electrodynamics of this region using Van Allen Probes data required that the ∼1 mV/m electric field (E‐field) of interest be measured in a region where the E‐field due to spacecraft motion was ∼100 mV/m. This means that the E‐field, the magnetic field, and the spacecraft velocity had to be measured to better than 1%. The instruments on board the Van Allen Probes have achieved this accuracy, delivering reliable near equatorial E‐field measurements even below three Earth radii. The objective of this commentary is to summarize the methodology developed over the years to maximize the accuracy and scientific return of these double probe E‐field measurements below L = 3.
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume
Authors: Zheng Yuanchao , Garrett Melanie E. , Sun Delin , Clarke-Rubright Emily K. , Haswell Courtney C. , Maihofer Adam X. , Elman Jeremy A. , Franz Carol E. , Lyons Michael J. , Kremen William S. , Peverill Matthew , Sambrook Kelly , McLaughlin Katie A. , Davenport Nicholas D. , Disner Seth , Sponheim Scott R. , Andrew Elpiniki , Korgaonkar Mayuresh , Bryant Richard , Varkevisser Tim , Geuze Elbert , Coleman Jonathan , Beckham Jean C. , Kimbrel Nathan A. , Sullivan Danielle , Miller Mark , Hayes Jasmeet , Verfaellie Mieke , Wolf Erika , Salat David , Spielberg Jeffrey M. , Milberg William , McGlinchey Regina , Dennis Emily L. , Thompson Paul M. , Medland Sarah , Jahanshad Neda , Nievergelt Caroline M. , Ashley-Koch Allison E. , Logue Mark W. , Morey Rajendra A. 
Published: December 2021

AbstractThe volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, environmental effects such as trauma, and disease effects such as posttraumatic stress disorder (PTSD). Trauma and PTSD represent potent exposures that may interact with genetic markers to influence brain structure and function. Genetic variants, associated with subcortical volumes in two large normative discovery samples, were used to compute polygenic scores (PGS) for the volume of seven subcortical structures. These were applied to a target sample enriched for childhood trauma and PTSD. Subcortical volume PGS from the discovery sample were strongly associated in our trauma/PTSD enriched sample (n = 7580) with respective subcortical volumes of the hippocampus (p = 1.10 × 10−20), thalamus (p = 7.46 × 10−10), caudate (p = 1.97 × 10−18), putamen (p = 1.7 × 10−12), and nucleus accumbens (p = 1.99 × 10−7). We found a significant association between the hippocampal volume PGS and hippocampal volume in control subjects from our sample, but was absent in individuals with PTSD (GxE; (beta = −0.10,p = 0.027)). This significant GxE (PGS × PTSD) relationship persisted (p < 1 × 10−19) in four out of five threshold peaks (0.024, 0.133, 0.487, 0.730, and 0.889) used to calculate hippocampal volume PGSs. We detected similar GxE (G × ChildTrauma) relationships in the amygdala for exposure to childhood trauma (rs4702973;p = 2.16 × 10−7) or PTSD (rs10861272;p = 1.78 × 10−6) in theCHST11gene. The hippocampus and amygdala are pivotal brain structures in mediating PTSD symptomatology. Trauma exposure and PTSD modulate the effect of polygenic markers on hippocampal volume (GxE) and the amygdala volume PGS is associated with PTSD risk, which supports the role of amygdala volume as a risk factor for PTSD.
Outcrossing rates in an experimentally admixed population of self-compatible and self-incompatible Arabidopsis lyrata
Authors: Steinecke Christina , Gorman Courtney E. , Stift Marc , Dorken Marcel E. 
Published: December 2021

AbstractThe transition to self-compatibility from self-incompatibility is often associated with high rates of self-fertilization, which can restrict gene flow among populations and cause reproductive isolation of self-compatible (SC) lineages. Secondary contact between SC and self-incompatible (SI) lineages might re-establish gene flow if SC lineages remain capable of outcrossing. By contrast, intrinsic features of SC plants that reinforce high rates of self-fertilization could maintain evolutionary divergence between lineages. Arabidopsis lyrata subsp. lyrata is characterized by multiple origins of self-compatibility and high rates of self-fertilization in SC-dominated populations. It is unclear whether these high rates of selfing by SC plants have intrinsic or extrinsic causes. We estimated outcrossing rates and examined patterns of pollinator movement for 38 SC and 40 SI maternal parents sampled from an admixed array of 1509 plants sourced from six SC and six SI populations grown under uniform density. Although plants from SI populations had higher outcrossing rates (mean tm = 0.78 ± 0.05 SE) than plants from SC populations (mean tm = 0.56 ± 0.06 SE), outcrossing rates among SC plants were substantially higher than previous estimates from natural populations. Patterns of pollinator movement appeared to contribute to lower outcrossing rates for SC plants; we estimated that 40% of floral visits were geitonogamous (between flowers of the same plant). The relatively high rates of outcrossing for SC plants under standardized conditions indicate that selfing rates in natural SC populations of A. lyrata are facultative and driven by extrinsic features of A. lyrata, including patterns of pollinator movement.
Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension
Authors: Grabowski Katja , Herlan Laura , Witten Anika , Qadri Fatimunnisa , Eisenreich Andreas , Lindner Diana , Schädlich Martin , Schulz Angela , Subrova Jana , Mhatre Ketaki Nitin , Primessnig Uwe , Plehm Ralph , van Linthout Sophie , Escher Felicitas , Bader Michael , Stoll Monika , Westermann Dirk , Heinzel Frank R. , Kreutz Reinhold 
Published: December 2021

AbstractTreatment of hypertension-mediated cardiac damage with left ventricular (LV) hypertrophy (LVH) and heart failure remains challenging. To identify novel targets, we performed comparative transcriptome analysis between genetic models derived from stroke-prone spontaneously hypertensive rats (SHRSP). Here, we identified carboxypeptidase X 2 (Cpxm2) as a genetic locus affecting LV mass. Analysis of isolated rat cardiomyocytes and cardiofibroblasts indicated Cpxm2 expression and intrinsic upregulation in genetic hypertension. Immunostaining indicated that CPXM2 associates with the t-tubule network of cardiomyocytes. The functional role of Cpxm2 was further investigated in Cpxm2-deficient (KO) and wild-type (WT) mice exposed to deoxycorticosterone acetate (DOCA). WT and KO animals developed severe and similar systolic hypertension in response to DOCA. WT mice developed severe LV damage, including increases in LV masses and diameters, impairment of LV systolic and diastolic function and reduced ejection fraction. These changes were significantly ameliorated or even normalized (i.e., ejection fraction) in KO-DOCA animals. LV transcriptome analysis showed a molecular cardiac hypertrophy/remodeling signature in WT but not KO mice with significant upregulation of 1234 transcripts, including Cpxm2, in response to DOCA. Analysis of endomyocardial biopsies from patients with cardiac hypertrophy indicated significant upregulation of CPXM2 expression. These data support further translational investigation of CPXM2.
Kaposi’s sarcoma-associated herpesvirus T cell responses in HIV seronegative individuals from rural Uganda
Authors: Nalwoga Angela , Roshan Romin , Moore Kyle , Marshall Vickie , Miley Wendell , Labo Nazzarena , Nakibuule Marjorie , Cose Stephen , Rochford Rosemary , Newton Robert , Whitby Denise 
Published: December 2021

AbstractT cell responses to Kaposi’s sarcoma-associated herpesvirus (KSHV) are likely essential in the control of KSHV infection and protection from associated disease, but remain poorly characterised. KSHV prevalence in rural Uganda is high at >90%. Here we investigate IFN- γ T cell responses to the KSHV proteome in HIV-negative individuals from a rural Ugandan population. We use an ex-vivo IFN- γ ELISpot assay with overlapping peptide pools spanning 83 KSHV open reading frames (ORF) on peripheral blood mononuclear cells (PBMC) from 116 individuals. KSHV-specific T cell IFN- γ responses are of low intensity and heterogeneous, with no evidence of immune dominance; by contrast, IFN- γ responses to Epstein–Barr virus, Cytomegalovirus and influenza peptides are frequent and intense. Individuals with KSHV DNA in PBMC have higher IFN- γ responses to ORF73 (p = 0.02) and lower responses to K8.1 (p = 0.004) when compared with those without KSHV DNA. In summary, we demonstrate low intensity, heterogeneous T cell responses to KSHV in immune-competent individuals.
The first true millipede—1306 legs long
Authors: Marek Paul E. , Buzatto Bruno A. , Shear William A. , Means Jackson C. , Black Dennis G. , Harvey Mark S. , Rodriguez Juanita 
Published: December 2021

AbstractThe name “millipede” translates to a thousand feet (from mille “thousand” and pes “foot”). However, no millipede has ever been described with more than 750 legs. We discovered a new record-setting species of millipede with 1,306 legs, Eumillipes persephone, from Western Australia. This diminutive animal (0.95 mm wide, 95.7 mm long) has 330 segments, a cone-shaped head with enormous antennae, and a beak for feeding. A distant relative of the previous record holder, Illacme plenipes from California, it belongs to a different order, the Polyzoniida. Discovered 60 m below ground in a drill hole created for mineral exploration, E. persephone possesses troglomorphic features; it lacks eyes and pigmentation, and it has a greatly elongated body—features that stand in stark contrast to its closest surface-dwelling relatives in Australia and all other members of its order. Using phylogenomics, we found that super-elongation (> 180 segments) evolved repeatedly in the millipede class Diplopoda. The striking morphological similarity between E. persephone and I. plenipes is a result of convergent evolution, probably for locomotion in similar soil habitats. Discovered in the resource-rich Goldfields-Esperance region and threatened by encroaching surface mining, documentation of this species and conservation of its habitat are of critical importance.
Genetically-predicted prefrontal DRD4 gene expression modulates differentiated brain responses to food cues in adolescent girls and boys
Authors: Portella Andre K. , Papantoni Afroditi , Joseph Antoneta T. , Chen Liuyi , Lee Richard S. , Silveira Patricia P. , Dube Laurette , Carnell Susan 
Published: December 2021

AbstractThe dopamine receptor 4 (DRD4) in the prefrontal cortex (PFC) acts to modulate behaviours including cognitive control and motivation, and has been implicated in behavioral inhibition and responsivity to food cues. Adolescence is a sensitive period for the development of habitual eating behaviors and obesity risk, with potential mediation by development of the PFC. We previously found that genetic variations influencing DRD4 function or expression were associated with measures of laboratory and real-world eating behavior in girls and boys. Here we investigated brain responses to high energy–density (ED) and low-ED food cues using an fMRI task conducted in the satiated state. We used the gene-based association method PrediXcan to estimate tissue-specific DRD4 gene expression in prefrontal brain areas from individual genotypes. Among girls, those with lower vs. higher predicted prefrontal DRD4 expression showed lesser activation to high-ED and low-ED vs. non-food cues in a distributed network of regions implicated in attention and sensorimotor processing including middle frontal gyrus, and lesser activation to low-ED vs non-food cues in key regions implicated in valuation including orbitofrontal cortex and ventromedial PFC. In contrast, males with lower vs. higher predicted prefrontal DRD4 expression showed minimal differences in food cue response, namely relatively greater activation to high-ED and low-ED vs. non-food cues in the inferior parietal lobule. Our data suggest sex-specific effects of prefrontal DRD4 on brain food responsiveness in adolescence, with modulation of distributed regions relevant to cognitive control and motivation observable in female adolescents.
Distance sampling surveys reveal 17 million vertebrates directly killed by the 2020’s wildfires in the Pantanal, Brazil
Authors: Tomas Walfrido Moraes , Berlinck Christian Niel , Chiaravalloti Rafael Morais , Faggioni Gabriel Paganini , Strüssmann Christine , Libonati Renata , Abrahão Carlos Roberto , do Valle Alvarenga Gabriela , de Faria Bacellar Ana Elisa , de Queiroz Batista Flávia Regina , Bornato Thainan Silva , Camilo André Restel , Castedo Judite , Fernando Adriana Maria Espinóza , de Freitas Gabriel Oliveira , Garcia Carolina Martins , Gonçalves Henrique Santos , de Freitas Guilherme Mariella Butti , Layme Viviane Maria Guedes , Lustosa Ana Paula Gomes , De Oliveira Ailton Carneiro , da Rosa Oliveira Maxwell , de Matos Martins Pereira Alexandre , Rodrigues Julia Abrantes , Semedo Thiago Borges Fernandes , de Souza Rafael Augusto Ducel , Tortato Fernando Rodrigo , Viana Diego Francis Passos , Vicente-Silva Luciana , Morato Ronaldo 
Published: December 2021

AbstractAnthropogenic factors have significantly influenced the frequency, duration, and intensity of meteorological drought in many regions of the globe, and the increased frequency of wildfires is among the most visible consequences of human-induced climate change. Despite the fire role in determining biodiversity outcomes in different ecosystems, wildfires can cause negative impacts on wildlife. We conducted ground surveys along line transects to estimate the first-order impact of the 2020 wildfires on vertebrates in the Pantanal wetland, Brazil. We adopted the distance sampling technique to estimate the densities and the number of dead vertebrates in the 39,030 square kilometers affected by fire. Our estimates indicate that at least 16.952 million vertebrates were killed immediately by the fires in the Pantanal, demonstrating the impact of such an event in wet savanna ecosystems. The Pantanal case also reminds us that the cumulative impact of widespread burning would be catastrophic, as fire recurrence may lead to the impoverishment of ecosystems and the disruption of their functioning. To overcome this unsustainable scenario, it is necessary to establish proper biomass fuel management to avoid cumulative impacts caused by fire over biodiversity and ecosystem services.
Accelerated synthesis of energetic precursor cage compounds using confined volume systems
Authors: Brown Hilary M. , Doppalapudi Karan R. , Fedick Patrick W. 
Published: December 2021

AbstractConfined volume systems, such as microdroplets, Leidenfrost droplets, or thin films, can accelerate chemical reactions. Acceleration occurs due to the evaporation of solvent, the increase in reactant concentration, and the higher surface-to-volume ratios amongst other phenomena. Performing reactions in confined volume systems derived from mass spectrometry ionization sources or Leidenfrost droplets allows for reaction conditions to be changed quickly for rapid screening in a time efficient and cost-saving manner. Compared to solution phase reactions, confined volume systems also reduce waste by screening reaction conditions in smaller volumes prior to scaling. Herein, the condensation of glyoxal with benzylamine (BA) to form hexabenzylhexaazaisowurtzitane (HBIW), an intermediate to the highly desired energetic compound 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), was explored. Five confined volume systems were compared to evaluate which technique was ideal for forming this complex cage structure. Substituted amines were also explored as BA replacements to screen alternative cage structure intermediates and evaluate how these accelerated techniques could apply to novel reactions, discover alternative reagents to form the cage compound, and improve synthetic routes for the preparation of CL-20. Ultimately, reaction acceleration is ideal for predicting the success of novel reactions prior to scaling up and determining if the expected products form, all while saving time and reducing costs. Acceleration factors and conversion ratios for each reaction were assessed by comparing the amount of product formed to the traditional bulk solution phase synthesis.
Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice
Authors: Ong Hui Ming , Azmi Ahmad Farhan Ahmad , Leong Sze Wei , Abas Faridah , Perimal Enoch Kumar , Farouk Ahmad Akira Omar , Israf Daud Ahmad , Sulaiman Mohd Roslan 
Published: December 2021

AbstractA novel synthetic compound from the 2-benzoyl-6-benzylidenecyclohexanone analogue, namely 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC), showed pronounced nitric oxide inhibition in IFN-γ/LPS-induced RAW 264.7 cells. Based on this previous finding, our present study aimed to investigate the antinociceptive effects of BBHC via chemical and thermal stimuli in vivo. The investigation of the antinociceptive activity of BBHC (0.1, 0.3, 1.0 and 3.0 mg/kg, i.p.) was initiated with 3 preliminary screening tests, then BBHC was subjected to investigate its possible involvement with excitatory neurotransmitters and opioid receptors. The potential acute toxicity of BBHC administration was also studied. Administration of BBHC significantly inhibited acetic acid-induced abdominal constrictions, formalin-induced paw licking activity and developed notable increment in the latency time. BBHC’s ability to suppress capsaicin- and glutamate-induced paw licking activities, as well as to antagonise the effect of naloxone, had indicated the possible involvement of its antinociception with TRPV1, glutamate and opioid receptors, respectively. The antinociceptive activities of BBHC was not related to any sedative action and no evidence of acute toxic effect was detected. The present study showed that BBHC possessed significant peripheral and central antinociceptive activities via chemical- and thermal-induced nociceptive murine models without any locomotor alteration and acute toxicity.
Association between albumin infusion and outcomes in patients with acute kidney injury and septic shock
Authors: Ge Chenglong , Peng Qianyi , Chen Wei , Li Wenchao , Zhang Lina , Ai Yuhang 
Published: December 2021

AbstractSeptic shock with acute kidney injury (AKI) is common in critically ill patients. Our aim was to evaluate the association between albumin infusion and outcomes in patients with septic shock and AKI. Medical Information Mart for Intensive Care (MIMIC)-III was used to identify patients with septic shock and AKI. Propensity score matching (PSM) was employed to balance the baseline differences. Cox proportional hazards model, Wilcoxon rank-sum test, and logistic regression were utilized to determine the associations of albumin infusion with mortality, length of stay, and recovery of kidney function, respectively. A total of 2861 septic shock patients with AKI were studied, including 891 with albumin infusion, and 1970 without albumin infusion. After PSM, 749 pairs of patients were matched. Albumin infusion was associated with improved 28-day survival (HR 0.72; 95% CI 0.59–0.86; P = 0.002), but it was not difference in 90-day mortality between groups (HR 0.94; 95% CI 0.79–1.12; P = 0.474). Albumin infusion was not associated with the renal function recovery (HR 0.91; 95% CI 0.73–1.13; P = 0.393) in either population. Nevertheless, subgroup analysis showed that albumin infusion was distinctly associated with reduced 28-day mortality in patients with age > 60 years. The results need to be validated in more randomized controlled trials.