bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of private sector quality care amongst mothers, newborns, and children in low- and middle-income countries: a systematic review
Authors: Strong Joe , Lattof Samantha R. , Maliqi Blerta , Yaqub Nuhu 
Published: December 2021

Abstract
Background
Experience of care is a pillar of quality care; positive experiences are essential during health care encounters and integral to quality health service delivery. Yet, we lack synthesised knowledge of how private sector delivery of quality care affects experiences of care amongst mothers, newborns, and children. To fill this gap, we conducted a systematic review that examined quantitative, qualitative, and mixed-methods studies on the provision of maternal, newborn, and child health (MNCH) care by private providers in low- and middle-income countries (LMICs). This manuscript focuses on experience of care, including respectful care, and satisfaction with care.

Methods
Our protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Searches were conducted in eight electronic databases (Cumulative Index to Nursing and Allied Health, EconLit, Excerpta Medica Database, International Bibliography of the Social Sciences, Popline, PubMed, ScienceDirect, and Web of Science) and two websites and supplemented with hand-searches and expert recommendations. For inclusion, studies examining private sector delivery of quality care amongst mothers, newborns, and children in LMICs must have examined maternal, newborn, and/or child morbidity or mortality; quality of care; experience of care; and/or service utilisation. Data were extracted for descriptive statistics and thematic analysis.

Results
Of the 139 studies included, 45 studies reported data on experience of care. Most studies reporting experience of care were conducted in India, Bangladesh, and Uganda. Experiences of private care amongst mothers, newborns, and children aligned with four components of quality of care: patient-centeredness, timeliness, effectiveness, and equity. Interpersonal relationships with health care workers were essential to experience of care, in particular staff friendliness, positive attitudes, and time spent with health care providers. Experience of care can be a stronger determining factor in MNCH-related decision-making than the quality of services provided.

Conclusion
Positive experiences of care in private facilities can be linked more broadly to privileges of private care that allow for shorter waiting times and more provider time spent with mothers, newborns, and children. Little is known about experiences of private sector care amongst children.

Trial registration
This systematic review was registered with the PROSPERO international prospective register of systematic reviews (registration number CRD42019143383).
Level and determinants of county health system technical efficiency in Kenya: two stage data envelopment analysis
Authors: Barasa Edwine , Musiega Anita , Hanson Kara , Nyawira Lizah , Mulwa Andrew , Molyneux Sassy , Maina Isabel , Tsofa Benjamin , Normand Charles , Jemutai Julie 
Published: December 2021

Abstract
Background
Improving health system efficiency is a key strategy to increase health system performance and accelerate progress towards Universal Health Coverage. In 2013, Kenya transitioned into a devolved system of government granting county governments autonomy over budgets and priorities. We assessed the level and determinants of technical efficiency of the 47 county health systems in Kenya.

Methods
We carried out a two-stage data envelopment analysis (DEA) using Simar and Wilson’s double bootstrap method using data from all the 47 counties in Kenya. In the first stage, we derived the bootstrapped DEA scores using an output orientation. We used three input variables (Public county health expenditure, Private county health expenditure, number of healthcare facilities), and one outcome variable (Disability Adjusted Life Years) using 2018 data. In the second stage, the bias corrected technical inefficiency scores were regressed against 14 exogenous factors using a bootstrapped truncated regression.

Results
The mean bias-corrected technical efficiency score of the 47 counties was 69.72% (95% CI 66.41–73.01%), indicating that on average, county health systems could increase their outputs by 30.28% at the same level of inputs. County technical efficiency scores ranged from 42.69% (95% CI 38.11–45.26%) to 91.99% (95% CI 83.78–98.95%). Higher HIV prevalence was associated with greater technical inefficiency of county health systems, while higher population density, county absorption of development budgets, and quality of care provided by healthcare facilities were associated with lower county health system inefficiency.

Conclusions
The findings from this analysis highlight the need for county health departments to consider ways to improve the efficiency of county health systems. Approaches could include prioritizing resources to interventions that will reduce high chronic disease burden, filling structural quality gaps, implementing interventions to improve process quality, identifying the challenges to absorption rates and reforming public finance management systems to enhance their efficiency.
CircSERPINA3 regulates SERPINA3-mediated apoptosis, autophagy and aerobic glycolysis of prostate cancer cells by competitively binding to MiR-653-5p and recruiting BUD13
Authors: Xing Zengshu , Li Sailian , Liu Zhenxiang , Zhang Chong , Bai Zhiming 
Published: December 2021

Abstract
Background
Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has been reported to be up-regulated in PCa. However, its biological function remains unclear.

Purpose
This study aimed to reveal the specific role and relevant molecular mechanism of circSERPINA3 in PCa.

Methods
RT-qPCR was used to examine gene expression and functional analyses were conducted to verify the effect of circSERPINA3 on cell apoptosis, autophagy and aerobic glycolysis in PCa cells. Mechanism assays were applied to evaluate the relationship among circSERPINA3/miR-653-5p/SERPINA3/BUD13.

Results
CircSERPINA3 was verified to be up-regulated in PCa cells and to inhibit cell apoptosis while promoting aerobic glycolysis and autophagy in PCa cells. CircSERPINA3 and SERPINA3 were also testified to bind to miR-653-5p through a line of mechanism experiments. Moreover, it was discovered that circSERPINA3 could stabilize SERPINA3 mRNA via recruiting BUD13. Additionally, SERPINA3 was verified to inhibit cell apoptosis, while promoting aerobic glycolysis and autophagy in PCa cells.

Conclusions
Our study suggested that circSERPINA3 regulated apoptosis, autophagy and aerobic glycolysis of PCa cells by competitively binding to miR-653-5p and recruiting BUD13.

Graphic abstract
Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus
Authors: Wang Yue , Chen Xuejuan , Jiang Tao , Gu Yayun , Zhang Xiaohan , Yuan Wenwen , Zhao Andi , Li Rui , Wang Zijin , Hu Zhibin , Liu Hu 
Published: December 2021

Abstract
Background
Comitant strabismus (CS) is a heterogeneous disorder that is a major contributing factor to unilateral childhood-onset visual impairment. Studies have confirmed that genetic factors play an important role in the development of CS. The aim of this study was to identify the genetic cause of non-syndromic familial CS.

Methods
Fourteen unrelated CS families were recruited for the study. Twelve affected and 2 unaffected individuals from a large four-generation family (CS08) were selected to perform whole genome-wide linkage analysis. Parallel whole-exome sequencing (WES) was conducted in the same family (9 patients and 1 unaffected member) and 31 additional CS cases from 13 other unrelated families. Sanger sequencing was used to determine whether any of the remaining variants co-segregated with the disease phenotype in the corresponding family.

Results
Based on linkage analysis, CS in family CS08 mapped to a novel region of 34.17 centimorgan (cM) on chromosome 2q22.3-2q32.1 between markers D2S151 and D2S364, with a maximum log odds (LOD) score of 3.54 (theta = 0) at D2S142. Parallel WES identified a heterozygous variant, LRP2 c.335 A > G (p.Q112R), located in such a linkage interval that completely co-segregated with the disease in the family. Furthermore, another novel heterozygous variant (c.7274A > G, p.D2425G) in LRP2 that co-segregated was detected in 2 additional affected individuals from another unrelated family by WES. Both variants are predicted to be damaging by PolyPhen-2, SIFT and MutationTaster, and were absent in 100 ethnically matched normal controls.

Conclusion
LRP2 is a novel candidate genetic cause of non-syndromic familial CS.
Anti-neuron antibody syndrome: clinical features, cytokines/chemokines and predictors
Authors: Liao Shaohua , Li Chuanfen , Bi Xiaoying , Guo Hongwei , Qian Ying , Liu Xiaobei , Miao Shuai , Hu Huaiqiang , Cao Bingzhen 
Published: December 2021

Abstract
Background
Neuroimmunology is a rapidly expanding field, and there have been recent discoveries of new antibodies and neurological syndromes. Most of the current clinical studies have focused on disorders involving one specific antibody. We have summarized a class of antibodies that target common neuronal epitopes, and we have proposed the term “anti-neuron antibody syndrome” (ANAS). In this study, we aimed to clarify the clinical range and analyse the clinical features, cytokines/chemokines and predictors in ANAS.

Methods
This was a retrospective cohort study investigating patients with neurological manifestations that were positive for anti-neuron antibodies.

Results
A total of 110 patients were identified, of which 43 patients were classified as having autoimmune encephalitis (AE) and the other 67 were classified as having paraneoplastic neurological syndrome (PNS). With regards to anti-neuron antibodies, 42 patients tested positive for anti-N-methyl-D-aspartate receptor (NMDAR) antibody, 19 for anti-Hu, 14 for anti-Yo and 12 for anti-PNMA2 (Ma2). There were significant differences between the ANAS and control groups in serum B cell-activating factor (BAFF) levels and in cerebrospinal fluid (CSF) C-X-C motif chemokine10 (CXCL10), CXCL13, interleukin10 (IL10), BAFF and transforming growth factor β1 (TGFβ1) levels. Predictors of poor outcomes included having tumours (P = 0.0193) and having a chronic onset (P = 0.0306), and predictors of relapses included having lower levels of CSF BAFF (P = 0.0491) and having a larger ratio of serum TGFβ1/serum CXCL13 (P = 0.0182).

Conclusions
Most patients with ANAS had a relatively good prognosis. Having tumours and a chronic onset were both associated with poor outcomes. CSF BAFF and the ratio of serum TGFβ1/serum CXCL13 were associated with relapses.
Knowledge, attitudes and behaviors of Latinas in cleaning occupations in northern New Jersey: a cross-sectional mixed methods study
Authors: Speiser Erin , Pinto Zipp Genevieve , DeLuca Deborah A. , Cupertino Ana Paula , Arana-Chicas Evelyn , Gourna Paleoudis Elli , Kligler Benjamin , Cartujano-Barrera Francisco 
Published: December 2021

AbstractBackgroundIn the United States, 88.3% of all 1,163,000 maids and housekeeping cleaners are female, and approximately half of them Latinas. Latinas are understudied and underrepresented in health research, particularly involving chemical exposure in cleaning practices, lack of job training, and inadequate access to personal protective equipment. The purpose of this study is twofold: 1) to examine the knowledge (via training experiences), attitudes and behaviors of a heterogeneous group of Latinas who clean occupationally and 2) to assess their cleaning practices at work and at home.MethodsThis mixed-method study consisted of two phases: 1) three focus groups to explore knowledge (via training experiences), attitudes, and behaviors regarding cleaning practices (N = 15) and 2) a 43-question cross-sectional survey. Focus group audio recordings were analyzed using descriptive and in vivo coding and then coded inductively to explore thematic analysis. Statistical analysis of the survey evaluated means, frequency and percentage for each of the responses.ResultsParticipants (n = 9) were women (mean age = 48.78 and SD = 6.72) from South America (n = 5), Mexico (n = 1), El Salvador (n = 1) and Dominican Republic (n = 2). The mean length of time living in the US was 18.78 years and over half (55.6%) worked in the cleaning industry for 10 or more years.Findings from the three focus groups (n = 15) included that training in cleaning often occurred informally at a very young age at home. Participants reported cleaning in groups where tasks are rotated and/or shared. Most were the primary person cleaning at home, suggesting increased exposure. Gloves and masks were the most frequently used PPE, but use was not consistent. For participants who purchase their own products, driving factors included price, smell and efficacy. Some participants used products supplied or preferred by the employer.ConclusionsLatinas in cleaning occupations face a range of social and health barriers including lack of safety and health training, inadequate PPE and low literacy. To address these issues, the development of an intervention is warranted to provide training and resources for this critical population of essential workers.
INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial
Authors: Song Lili , Chen Chen , Chen Xiaoying , Guo Yijia , Liu Feifeng , Lin Yapeng , Billot Laurent , Li Qiang , Liu Hueiming , Si Lei , Ouyang Menglu , Arima Hisatomi , Bath Philip M. , Ford Gary A. , Robinson Thompson , Sandset Else Charlotte , Saver Jeffrey L. , Sprigg Nikola , van der Worp H. Bart , Zhang Chunfang , Yang Jie , Li Gang , Anderson Craig S. ,   for the INTERACT4 investigators, Anderson C. S. , Li G. , Yang J. , Song L. , Arima H. , Bath P. , Robinson T. , Ford G. , Sprigg N. , Sandset E. , Saver J. , Worp B. , Liu Z. , Dawson J. , Wong L. , Peng B. , Billot L. , Li Q. , Ning Y. , Song L. , Chen X. , Yang Z. , Yu W. , Li G. , Chen C. , Liu F. , Yang J. , Guo Y. , Lin Y. , Hu R. , Cheng H. , Ma W. , Liao K. , Zhang C. , Jin H. , Li G. , Yang J. , Xu P. , Wu X. , Wang F. , Wu L. , Wang C. , Peng Y. , Zhao X. , Xu X. , Liu X. , Song X. , Li Z. , Zhang H. , Yu D. , Wang Y. , Tang X. , Liu H. , Cao X. , Liu Y. , Duan Y. , Liu H. , Li C. , Huang J. , Li H. , Fan C. , Tang Y. , Ji Y. , Li G. , Huang Y. , Chen G. , Wang J. 
Published: December 2021

Abstract
Background
Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment and risk of intracranial hemorrhage in ischemic stroke (IS). We present the design of the fourth INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4).

Methods
A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed trial of pre-hospital BP lowering in 3116 hypertensive patients with suspected acute stroke at 50+ sites in China. Patients are randomized through a mobile phone digital system to intensive BP lowering to a target systolic BP of < 140 mmHg within 30 min, or guideline-recommended BP management according to local protocols. After the collection of in-hospital clinical and management data and 7-day outcomes, trained blinded assessors conduct telephone or face-to-face assessments of physical function and health-related quality of life in participants at 90 days. The primary outcome is the physical function on the modified Rankin scale at 90 days, analyzed as an ordinal outcome with 7 categories. The sample size was estimated to provide 90% power (α = 0.05) to detect a 22% reduction in the odds of a worse functional outcome using ordinal logistic regression.

Discussion
INTERACT4 is a pragmatic clinical trial to provide reliable evidence on the effectiveness and safety of ambulance-delivered hyperacute BP lowering in patients with suspected acute stroke.

Trial registration
ClinicalTrials.gov NCT03790800. Registered on 2 January 2019; Chinese Trial Registry ChiCTR1900020534. Registered on 7 January 2019. All items can be found in this protocol paper.
COVID-19 triage in general adult in-patient psychiatry: perspectives from clinicians on a novel triage ward during the pandemic
Authors: Williams Ryan , Cranshaw Joanna , Pinto da Costa Mariana 
Published: December 2021

SUMMARYIntra-hospital transmission of COVID-19 is a major concern. To mitigate this risk, ‘COVID-triage’ psychiatric wards were implemented by some in-patient service providers in the UK. Although the effectiveness of this model has not been investigated, there are questions about the benefits and detriments of this model of care for patients and staff. This reflection draws from the experiences of clinicians who were redeployed from their planned clinical posts (and training rotations, in the case of trainees) to staff a newly established COVID-triage ward at a large urban mental healthcare provider, between August 2020 and March 2021.
Integration of Magnetic Capture and SERS Signal Probes for Sensitive Competitive Aptamer-based Detection of Cardiac Troponin I
Authors: Lin Chubing , Li Lijun , He Yuhan , Zhang Yan 
Published: December 2021

Abstract
In this study, a high sensitivity bimetallic SERS substrate Au@Ag is introduced with an EF of about 2.03 × 1011 to construct a competitive SERS aptasensor integrated aptamer and magnetic capture for detection of cardiac troponin I (cTnI). The aptasensor shows low quantitative concentration of detection (0.01 ng/mL), great linear relationship (R2 = 0.993) between SERS intensity and Log value of cTnI concentration (0.01 ng/mL–1.00 ng/mL). The proposed method is a rapid and sensitive detection of SERS aptasenor for cardiac troponin I, which has great application potential in clinic detection.
Efficient Solution Methods for a General r-Interdiction Median Problem with Fortification
Authors: Zhang Kaike , Li Xueping , Jin Mingzhou 
Published: December 2021

This study generalizes the r-interdiction median (RIM) problem with fortification to simultaneously consider two types of risks: probabilistic exogenous disruptions and endogenous disruptions caused by intentional attacks. We develop a bilevel programming model that includes a lower-level interdiction problem and a higher-level fortification problem to hedge against such risks. We then prove that the interdiction problem is supermodular and subsequently adopt the cuts associated with supermodularity to develop an efficient cutting-plane algorithm to achieve exact solutions. For the fortification problem, we adopt the logic-based Benders decomposition (LBBD) framework to take advantage of the two-level structure and the property that a facility should not be fortified if it is not attacked at the lower level. Numerical experiments show that the cutting-plane algorithm is more efficient than benchmark methods in the literature, especially when the problem size grows. Specifically, with regard to the solution quality, LBBD outperforms the greedy algorithm in the literature with an up-to 13.2% improvement in the total cost, and it is as good as or better than the tree-search implicit enumeration method. Summary of Contribution: This paper studies an r-interdiction median problem with fortification (RIMF) in a supply chain network that simultaneously considers two types of disruption risks: random disruptions that occur probabilistically and disruptions caused by intentional attacks. The problem is to determine the allocation of limited facility fortification resources to an existing network. It is modeled as a bilevel programming model combining a defender’s problem and an attacker’s problem, which generalizes the r-interdiction median problem with probabilistic fortification. This paper is suitable for IJOC in mainly two aspects: (1) The lower-level attacker’s interdiction problem is a challenging high-degree nonlinear model. In the literature, only a total enumeration method has been applied to solve a special case of this problem. By exploring the special structural property of the problem, namely, the supermodularity of the transportation cost function, we developed an exact cutting-plane method to solve the problem to its optimality. Extensive numerical studies were conducted. Hence, this paper fits in the intersection of operations research and computing. (2) We developed an efficient logic-based Benders decomposition algorithm to solve the higher-level defender’s fortification problem. Overall, this study generalizes several important problems in the literature, such as RIM, RIMF, and RIMF with probabilistic fortification (RIMF-p).
Design and evaluation of a cognitive health education pilot program according to the RE-AIM framework
Authors: Yuan Manqiong , Xiao Xiao , Wang Yifan , Han Yaofeng , Zhang Rongmu , Fu Hanhan , Fang Ya 
Published: December 2021

Objective
Most formats of currently used community-based health education for cognitive impairment prevention are limited to one-way communication, such as distributing leaflets, pasting posters, or holding a lecture, and they lack comprehensive evaluation. Here we aim to design, test, and evaluate a novel pilot cognitive health education program combined with psychosocial interventions (CHECPI).

Methods
We designed the CHECPI program and tested it among adults aged 60 and over in an aging-friendly community in 2018. Multidimensional cognitive functions were measured by the Montreal Cognitive Assessment (MoCA) before and three months after the CHECPI program. Quantitative and qualitative analyses were performed based on the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework to evaluate the program. Wilcoxon signed-rank tests were used to assess changes in multidimensional cognitive functions.

Results
The CHECPI program was comprised of 12 courses and introduced 5 kinds of psychosocial interventions. Reach: 28 older adults participated in the program, of whom most were female (n = 22) and younger elderly with an average age of 65.32 years. Effectiveness: 19 participants finished≥6 courses as well as the follow-up survey. Although their MoCA scores did not improve significantly, they had increased their visuospatial ability significantly (with the average score increasing by 0.42). Adoption: the community officers, lecturers, and participants highly recommended the program, but they agreed that the lack of professional instructors may hinder its popularization. Implementation: the program was implemented in full accordance with the pre-program design. Maintenance: three months after the program, 17 participants had maintained at least one of the seven healthy behaviors that were introduced in the program.

Conclusions
Younger female elderly were more willing to participate in the program. It enhanced participants’ visuospatial ability, but a sufficient number of professional instructors are crucial for large-scale promotion.
The ousiakos logos, the procurator usiacus, and ousiake ge: was it Vespasian, Domitian or Hadrian?
Authors: Broux Yanne 
Published: December 2021

Abstract
This article challenges the consensus that the Flavians carried out major reforms of imperial properties by creating a separate department, the ousiakos logos, headed by a procurator usiacus, to manage these lands, and that this situation remained unchanged until Diocletian. The available evidence rather points to a reorganization under Hadrian, which was the culmination of a gradual institutionalization of ousiac land in the previous decades.